# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- GFA PF04828.12 MSTRG.22853.3_2 - 1.7e-09 37.7 1.4 4.1e-09 36.5 1.4 1.6 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme UCR_hinge PF02320.14 MSTRG.23742.2_2 - 6.1e-22 77.5 8.3 9.4e-22 76.9 8.3 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein dNK PF01712.17 MSTRG.23742.2_2 - 0.1 12.3 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Deoxynucleoside kinase WD40 PF00400.30 MSTRG.5533.3_3 - 0.0012 19.4 5.4 0.088 13.6 0.1 5.0 5 1 0 5 5 5 1 WD domain, G-beta repeat dUTPase PF00692.17 MSTRG.17435.1_1 - 1.5e-47 160.3 0.0 2.2e-47 159.8 0.0 1.2 1 0 0 1 1 1 1 dUTPase DUF4795 PF16043.3 MSTRG.20755.1_1 - 0.00069 19.1 10.2 0.00093 18.7 10.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4795) IncA PF04156.12 MSTRG.20755.1_1 - 0.00073 19.2 9.2 0.00094 18.9 9.2 1.1 1 0 0 1 1 1 1 IncA protein DDHD PF02862.15 MSTRG.20755.1_1 - 0.033 14.2 2.6 0.038 14.0 2.6 1.1 1 0 0 1 1 1 0 DDHD domain Cluap1 PF10234.7 MSTRG.20755.1_1 - 0.041 13.1 8.2 0.063 12.5 8.2 1.2 1 0 0 1 1 1 0 Clusterin-associated protein-1 DUF2360 PF10152.7 MSTRG.20755.1_1 - 0.058 13.6 3.6 0.078 13.2 3.6 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) Spc7 PF08317.9 MSTRG.20755.1_1 - 0.075 11.8 12.5 0.094 11.4 12.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF2385 PF09539.8 MSTRG.20755.1_1 - 0.087 13.2 1.6 0.17 12.3 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2385) Spore_coat_CotO PF14153.4 MSTRG.20755.1_1 - 0.13 12.1 7.9 0.17 11.7 7.9 1.1 1 0 0 1 1 1 0 Spore coat protein CotO V_ATPase_I PF01496.17 MSTRG.20755.1_1 - 0.36 8.5 6.1 0.43 8.3 6.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ATPase_2 PF01637.16 MSTRG.20755.1_1 - 0.6 9.8 5.0 0.47 10.2 3.5 1.5 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea Neur_chan_memb PF02932.14 MSTRG.20755.1_1 - 0.94 9.4 4.5 1.3 8.9 4.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region She9_MDM33 PF05546.9 MSTRG.20755.1_1 - 1.1 8.9 10.3 1.5 8.4 9.9 1.5 1 1 0 1 1 1 0 She9 / Mdm33 family APG6 PF04111.10 MSTRG.20755.1_1 - 1.4 8.1 10.9 1.8 7.8 10.9 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 FUSC PF04632.10 MSTRG.20755.1_1 - 4.2 5.7 6.1 2.2 6.6 1.0 1.9 1 1 1 2 2 2 0 Fusaric acid resistance protein family DUF2205 PF10224.7 MSTRG.20755.1_1 - 4.7 7.2 10.2 0.51 10.2 0.2 2.6 1 1 1 2 2 2 0 Predicted coiled-coil protein (DUF2205) XhlA PF10779.7 MSTRG.20755.1_1 - 7.9 6.6 9.4 0.23 11.5 2.2 2.0 2 0 0 2 2 2 0 Haemolysin XhlA WD40 PF00400.30 MSTRG.15254.1_1 - 7.5e-56 184.7 32.7 1.2e-07 32.1 0.0 11.6 12 0 0 12 12 12 9 WD domain, G-beta repeat NB-ARC PF00931.20 MSTRG.15254.1_1 - 3.1e-51 174.0 0.0 4.8e-51 173.4 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain ANAPC4_WD40 PF12894.5 MSTRG.15254.1_1 - 1.2e-29 102.4 3.7 1.3e-05 25.3 0.0 9.2 2 1 6 9 9 9 8 Anaphase-promoting complex subunit 4 WD40 domain CARD PF00619.19 MSTRG.15254.1_1 - 4.2e-17 61.8 0.8 7.4e-15 54.6 0.1 2.7 2 0 0 2 2 2 1 Caspase recruitment domain Ge1_WD40 PF16529.3 MSTRG.15254.1_1 - 5.4e-13 48.5 8.2 0.0096 14.8 0.0 7.5 4 2 2 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.3 MSTRG.15254.1_1 - 2.5e-07 30.2 0.0 0.032 13.4 0.0 3.6 2 2 1 3 3 3 2 WD40-like domain eIF2A PF08662.9 MSTRG.15254.1_1 - 7.7e-07 29.0 0.8 1.3 8.8 0.0 5.0 2 2 2 5 5 5 3 Eukaryotic translation initiation factor eIF2A CARD_2 PF16739.3 MSTRG.15254.1_1 - 4.7e-06 26.4 0.0 1.7e-05 24.5 0.0 2.0 1 0 0 1 1 1 1 Caspase recruitment domain AAA_16 PF13191.4 MSTRG.15254.1_1 - 0.0032 17.7 0.0 0.011 16.0 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain DUF87 PF01935.15 MSTRG.15254.1_1 - 0.062 13.2 0.3 11 5.9 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function DUF87 7tm_1 PF00001.19 MSTRG.10006.1_2 - 3e-18 65.9 7.1 3.4e-18 65.7 7.1 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 MSTRG.10006.1_2 - 8.9e-06 25.5 1.1 1.1e-05 25.2 1.1 1.1 1 0 0 1 1 1 1 Olfactory receptor VWD PF00094.23 MSTRG.13443.1_2 - 1.2e-20 74.3 3.4 6.6e-11 42.6 0.1 2.6 2 0 0 2 2 2 2 von Willebrand factor type D domain C8 PF08742.9 MSTRG.13443.1_2 - 5.7e-19 68.2 0.6 5.7e-19 68.2 0.6 3.9 4 0 0 4 4 4 1 C8 domain TIL PF01826.15 MSTRG.13443.1_2 - 2.4e-10 40.3 17.2 2.4e-10 40.3 17.2 4.9 4 2 1 5 5 5 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.5 MSTRG.13443.1_2 - 8.9e-07 28.6 13.1 8.9e-07 28.6 13.1 3.6 2 1 2 4 4 4 1 TILa domain Ion_trans PF00520.29 MSTRG.14278.1_3 - 1.2e-21 76.9 14.0 2.1e-21 76.1 14.0 1.4 1 0 0 1 1 1 1 Ion transport protein Ion_trans_N PF08412.8 MSTRG.14278.1_3 - 1.1e-18 66.4 0.0 2.3e-18 65.4 0.0 1.6 1 0 0 1 1 1 1 Ion transport protein N-terminal cNMP_binding PF00027.27 MSTRG.14278.1_3 - 1e-16 60.6 0.0 1.9e-16 59.7 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.14 MSTRG.14278.1_3 - 0.004 17.0 0.4 0.0084 15.9 0.4 1.5 1 0 0 1 1 1 1 Ion channel Phage_int_SAM_4 PF13495.4 MSTRG.21291.1_1 - 0.027 14.8 0.1 0.069 13.5 0.0 1.6 1 1 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain UCH PF00443.27 MSTRG.8723.3_3 - 3e-33 115.2 0.0 5.2e-33 114.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.10 MSTRG.8723.3_3 - 1.4e-25 89.6 1.0 3.8e-14 53.0 0.0 2.8 3 0 0 3 3 3 2 DUSP domain UCH_1 PF13423.4 MSTRG.8723.3_3 - 1.5e-18 67.4 0.1 2.5e-18 66.6 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Myosin_head PF00063.19 MSTRG.3836.1_3 - 4.2e-240 798.4 1.2 5.5e-240 798.1 1.2 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.11 MSTRG.3836.1_3 - 4.3e-29 101.4 0.1 7.5e-29 100.6 0.1 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.25 MSTRG.3836.1_3 - 1.5e-06 27.3 10.8 0.0016 17.9 3.1 3.4 3 0 0 3 3 3 2 IQ calmodulin-binding motif AAA_22 PF13401.4 MSTRG.3836.1_3 - 0.13 12.4 0.0 0.35 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain RRM_1 PF00076.20 MSTRG.4179.3_2 - 7.6e-18 64.0 0.0 1.6e-17 62.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPR_2 PF07719.15 MSTRG.4179.3_2 - 3.1e-10 39.2 1.4 0.031 14.2 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.4179.3_2 - 5.4e-06 25.9 2.6 0.033 13.9 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.4179.3_2 - 6.7e-06 26.4 0.1 0.0072 16.7 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat RRM_occluded PF16842.3 MSTRG.4179.3_2 - 2.6e-05 23.9 0.0 4.8e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_5 PF13893.4 MSTRG.4179.3_2 - 7.8e-05 22.1 0.0 0.00017 21.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_3 PF15663.3 MSTRG.4179.3_2 - 0.0033 17.5 0.7 0.0092 16.1 0.7 1.7 1 0 0 1 1 1 1 Zinc-finger containing family TPR_16 PF13432.4 MSTRG.4179.3_2 - 0.0045 17.5 0.1 1.2 9.7 0.0 2.8 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.4179.3_2 - 0.005 17.0 0.1 0.019 15.2 0.2 2.0 1 1 1 2 2 2 1 Tetratricopeptide repeat zf-CCCH PF00642.22 MSTRG.4179.3_2 - 0.017 14.9 4.5 0.043 13.6 4.5 1.7 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) TPR_12 PF13424.4 MSTRG.4179.3_2 - 0.025 14.7 0.3 14 5.9 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.4179.3_2 - 0.031 15.0 0.6 5.3 8.0 0.0 3.6 3 1 1 4 4 3 0 Tetratricopeptide repeat RRM_3 PF08777.9 MSTRG.4179.3_2 - 0.035 14.0 0.0 0.035 14.0 0.0 2.5 2 0 0 2 2 2 0 RNA binding motif TPR_8 PF13181.4 MSTRG.4179.3_2 - 0.045 13.8 5.3 2.4 8.5 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.4179.3_2 - 0.096 12.3 0.5 0.4 10.3 0.0 2.3 2 1 0 2 2 2 0 TPR repeat PNISR PF15996.3 MSTRG.4179.3_2 - 1.6 8.7 24.3 2.8 7.9 24.3 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Hamartin PF04388.10 MSTRG.4179.3_2 - 1.8 7.0 13.4 2.5 6.5 13.4 1.1 1 0 0 1 1 1 0 Hamartin protein zf-CCCH_2 PF14608.4 MSTRG.4179.3_2 - 2.5 8.6 5.3 12 6.4 5.4 2.3 1 1 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Helicase_C_4 PF13871.4 MSTRG.20898.2_3 - 2.4e-60 204.3 0.0 3.2e-60 203.9 0.0 1.2 1 0 0 1 1 1 1 C-terminal domain on Strawberry notch homologue WW PF00397.24 MSTRG.17814.1_3 - 1.5e-21 75.9 1.9 3.6e-10 39.5 0.2 2.4 2 0 0 2 2 2 2 WW domain FAM181 PF15238.4 MSTRG.17814.1_3 - 0.00065 19.5 1.4 0.00065 19.5 1.4 2.1 2 0 0 2 2 2 1 FAM181 MbtH PF03621.11 MSTRG.17814.1_3 - 0.027 13.8 0.0 4.6 6.7 0.0 2.8 3 0 0 3 3 3 0 MbtH-like protein RNF111_N PF15303.4 MSTRG.12019.2_1 - 3.9e-55 187.5 35.2 6.2e-55 186.8 35.2 1.3 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase Arkadia N-terminus S_100 PF01023.17 MSTRG.24471.3_1 - 7.6e-12 44.6 0.9 1.4e-11 43.8 0.9 1.5 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_6 PF13405.4 MSTRG.24471.3_1 - 5.4e-05 22.7 1.5 0.0066 16.2 0.2 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.30 MSTRG.24471.3_1 - 0.00025 20.2 1.7 0.0014 17.9 0.4 2.2 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.4 MSTRG.24471.3_1 - 0.034 13.5 1.9 0.042 13.3 0.8 1.7 2 0 0 2 2 2 0 EF hand EF-hand_4 PF12763.5 MSTRG.24471.3_1 - 0.037 13.8 0.0 0.062 13.1 0.0 1.3 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.4 MSTRG.24471.3_1 - 0.041 14.2 0.7 0.12 12.8 0.7 1.7 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_8 PF13833.4 MSTRG.24471.3_1 - 0.049 13.3 3.5 0.15 11.7 2.4 2.2 2 0 0 2 2 2 0 EF-hand domain pair Glyco_hydro_18 PF00704.26 MSTRG.9737.1_1 - 6e-21 75.3 0.0 9.1e-21 74.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Mito_carr PF00153.25 MSTRG.3200.1_1 - 1.2e-64 214.1 1.6 8.7e-23 79.9 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein PDZ PF00595.22 MSTRG.13646.1_2 - 3.5e-70 232.2 8.8 5.7e-13 48.9 0.1 6.4 6 0 0 6 6 6 6 PDZ domain (Also known as DHR or GLGF) MAGI_u5 PF16666.3 MSTRG.13646.1_2 - 6.2e-39 133.1 9.7 6.2e-39 133.1 9.7 4.0 5 0 0 5 5 5 1 Unstructured region on MAGI PDZ_2 PF13180.4 MSTRG.13646.1_2 - 1.2e-27 95.9 1.3 0.00016 21.7 0.0 6.0 6 0 0 6 6 6 5 PDZ domain MAGI_u1 PF16663.3 MSTRG.13646.1_2 - 5.9e-19 67.7 0.9 5.9e-19 67.7 0.9 2.8 3 0 0 3 3 3 1 Unstructured region on MAGI WW PF00397.24 MSTRG.13646.1_2 - 5e-18 64.6 5.6 7.4e-10 38.5 0.3 2.7 2 0 0 2 2 2 2 WW domain Guanylate_kin PF00625.19 MSTRG.13646.1_2 - 1e-10 41.5 0.0 1.9e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Guanylate kinase Tricorn_PDZ PF14685.4 MSTRG.13646.1_2 - 4.6e-06 26.4 8.8 1.8 8.5 0.0 5.8 6 0 0 6 6 6 3 Tricorn protease PDZ domain p450 PF00067.20 MSTRG.24524.1_1 - 4.8e-55 187.0 0.0 5.5e-55 186.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 PhoLip_ATPase_N PF16209.3 MSTRG.24020.1_2 - 6.2e-24 83.4 2.4 6.2e-24 83.4 2.4 1.8 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.18 MSTRG.24020.1_2 - 1.2e-08 34.4 0.0 2.6e-08 33.3 0.0 1.5 2 0 0 2 2 2 1 E1-E2 ATPase Protocadherin PF08374.9 MSTRG.24020.1_2 - 0.079 12.8 2.6 0.16 11.8 2.6 1.4 1 0 0 1 1 1 0 Protocadherin ABC2_membrane_3 PF12698.5 MSTRG.25792.3_1 - 3.2e-53 180.9 36.3 1.4e-40 139.4 12.4 3.0 2 1 0 2 2 2 2 ABC-2 family transporter protein ABC_tran PF00005.25 MSTRG.25792.3_1 - 1e-51 174.9 0.0 1.6e-28 99.8 0.0 2.7 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.4 MSTRG.25792.3_1 - 1.3e-19 71.0 0.0 1.1e-06 28.5 0.0 4.3 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.4 MSTRG.25792.3_1 - 0.001 19.6 0.0 0.97 10.1 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4162) AAA_29 PF13555.4 MSTRG.25792.3_1 - 0.0091 15.6 2.4 0.19 11.3 0.5 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_23 PF13476.4 MSTRG.25792.3_1 - 0.014 15.8 4.9 0.15 12.4 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.4 MSTRG.25792.3_1 - 0.026 14.0 0.0 7.9 5.8 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain SRP54 PF00448.20 MSTRG.25792.3_1 - 0.031 13.8 1.5 4.7 6.6 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MukB PF04310.10 MSTRG.25792.3_1 - 6.9 6.3 5.4 2.6 7.7 0.1 2.5 3 0 0 3 3 3 0 MukB N-terminal Filament PF00038.19 MSTRG.13179.1_2 - 1e-103 347.1 33.6 1.2e-103 346.9 33.6 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 MSTRG.13179.1_2 - 0.0028 17.6 26.5 0.47 10.4 13.2 4.1 2 2 2 4 4 4 3 TPR/MLP1/MLP2-like protein Reo_sigmaC PF04582.10 MSTRG.13179.1_2 - 0.0031 16.8 10.7 0.15 11.3 4.6 3.0 1 1 2 3 3 3 2 Reovirus sigma C capsid protein RusA PF05866.9 MSTRG.13179.1_2 - 0.0044 17.4 1.9 0.0086 16.5 0.3 2.2 2 0 0 2 2 2 1 Endodeoxyribonuclease RusA Cep57_MT_bd PF06657.11 MSTRG.13179.1_2 - 0.012 16.0 3.3 0.012 16.0 3.3 4.2 2 1 2 5 5 4 0 Centrosome microtubule-binding domain of Cep57 CC2-LZ PF16516.3 MSTRG.13179.1_2 - 0.025 14.8 1.8 0.025 14.8 1.8 3.6 2 1 3 5 5 5 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Rab5-bind PF09311.9 MSTRG.13179.1_2 - 0.11 11.7 23.6 0.021 14.1 15.9 2.2 1 1 1 2 2 2 0 Rabaptin-like protein Bacillus_HBL PF05791.9 MSTRG.13179.1_2 - 0.14 11.8 12.2 0.015 14.9 5.1 2.4 2 1 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) IncA PF04156.12 MSTRG.13179.1_2 - 0.16 11.6 30.2 1.9 8.1 18.8 3.1 1 1 0 2 2 2 0 IncA protein CHDCT2 PF08074.9 MSTRG.13179.1_2 - 0.16 12.0 7.0 0.3 11.1 6.3 1.8 1 1 0 1 1 1 0 CHDCT2 (NUC038) domain Occludin_ELL PF07303.11 MSTRG.13179.1_2 - 0.24 12.0 12.4 4.2 8.0 0.2 3.7 2 1 1 3 3 3 0 Occludin homology domain Spc7 PF08317.9 MSTRG.13179.1_2 - 0.29 9.8 27.6 0.051 12.3 2.9 3.4 1 1 1 3 3 3 0 Spc7 kinetochore protein ADIP PF11559.6 MSTRG.13179.1_2 - 0.31 11.0 24.3 2.7 7.9 0.3 4.1 1 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding DUF1664 PF07889.10 MSTRG.13179.1_2 - 0.35 10.7 17.1 5.3 6.9 1.1 3.9 2 1 3 5 5 5 0 Protein of unknown function (DUF1664) Golgin_A5 PF09787.7 MSTRG.13179.1_2 - 0.37 10.1 25.5 0.047 13.0 10.5 2.8 1 1 2 3 3 3 0 Golgin subfamily A member 5 Jnk-SapK_ap_N PF09744.7 MSTRG.13179.1_2 - 0.39 10.8 24.8 0.49 10.5 10.0 3.9 1 1 3 4 4 4 0 JNK_SAPK-associated protein-1 CENP-F_leu_zip PF10473.7 MSTRG.13179.1_2 - 0.76 9.7 26.5 13 5.7 15.8 3.8 1 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 COMP PF11598.6 MSTRG.13179.1_2 - 1.5 9.2 9.3 7.5 7.0 0.1 4.0 3 1 1 4 4 3 0 Cartilage oligomeric matrix protein DUF4446 PF14584.4 MSTRG.13179.1_2 - 2 8.2 13.2 0.87 9.4 0.1 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF4446) ERM PF00769.17 MSTRG.13179.1_2 - 3.4 7.3 22.5 17 5.0 19.4 2.2 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Phage_GPO PF05929.9 MSTRG.13179.1_2 - 4.2 6.8 9.7 2.5 7.5 7.4 1.8 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF3450 PF11932.6 MSTRG.13179.1_2 - 5.1 6.2 29.2 0.97 8.5 0.4 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) EF-hand_7 PF13499.4 MSTRG.2385.1_1 - 5.9e-21 74.6 12.4 4.4e-07 30.1 0.1 4.2 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.30 MSTRG.2385.1_1 - 1.5e-18 64.8 12.8 0.00057 19.1 0.1 6.1 6 0 0 6 6 6 5 EF hand EF-hand_6 PF13405.4 MSTRG.2385.1_1 - 3.8e-14 51.2 10.1 0.035 13.9 0.0 6.0 6 0 0 6 6 6 5 EF-hand domain EF-hand_8 PF13833.4 MSTRG.2385.1_1 - 9.7e-11 41.1 12.8 0.0025 17.4 0.0 5.3 6 0 0 6 6 6 3 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.2385.1_1 - 6.1e-10 38.0 21.5 0.0026 17.1 0.1 6.1 7 0 0 7 7 7 4 EF hand Unstab_antitox PF09720.8 MSTRG.2385.1_1 - 0.12 12.3 3.4 1.1 9.3 0.2 2.6 2 0 0 2 2 2 0 Putative addiction module component TMEM237 PF15383.4 MSTRG.13908.1_3 - 0.1 11.6 2.5 1.1 8.1 0.5 2.1 2 0 0 2 2 2 0 Transmembrane protein 237 PRY PF13765.4 MSTRG.12918.1_2 - 2.3e-13 49.4 0.3 2.3e-13 49.4 0.3 2.2 2 0 0 2 2 2 1 SPRY-associated domain SPRY PF00622.26 MSTRG.12918.1_2 - 1.1e-06 28.6 0.0 1.9e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 SPRY domain Mitofilin PF09731.7 MSTRG.12918.1_2 - 0.0034 16.1 3.4 0.0048 15.6 3.4 1.1 1 0 0 1 1 1 1 Mitochondrial inner membrane protein Apolipoprotein PF01442.16 MSTRG.12918.1_2 - 0.016 15.0 3.8 0.025 14.3 3.8 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain HAUS-augmin3 PF14932.4 MSTRG.12918.1_2 - 0.032 13.6 1.3 0.051 12.9 1.3 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF3619 PF12279.6 MSTRG.12918.1_2 - 0.044 14.0 0.6 0.087 13.0 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3619) Vg_Tdu PF07545.12 MSTRG.12918.1_2 - 0.053 13.1 0.2 0.12 12.0 0.2 1.5 1 0 0 1 1 1 0 Vestigial/Tondu family DUF4078 PF13300.4 MSTRG.12918.1_2 - 1.5 9.0 6.1 2.5 8.3 6.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4078) UPF0728 PF15092.4 MSTRG.26768.3_1 - 0.15 11.8 0.3 0.31 10.8 0.3 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0728 zf-H2C2_2 PF13465.4 MSTRG.26768.3_2 - 7.9e-28 95.5 29.4 1.1e-10 41.4 0.2 5.6 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.26768.3_2 - 6.3e-18 64.0 31.7 9.2e-06 25.7 1.1 5.4 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.26768.3_2 - 2.2e-14 52.7 26.7 0.0009 19.7 0.1 5.1 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.26768.3_2 - 3.5e-05 23.9 1.5 0.64 10.3 0.0 4.5 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 MSTRG.26768.3_2 - 5.5e-05 22.7 19.5 0.013 15.1 0.3 4.8 4 0 0 4 4 4 3 zinc-finger C2H2-type zf-met PF12874.5 MSTRG.26768.3_2 - 0.00021 21.4 20.2 0.038 14.3 1.1 5.3 5 0 0 5 5 5 2 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.8 MSTRG.26768.3_2 - 0.00077 19.4 4.2 0.00077 19.4 4.2 2.8 3 0 0 3 3 3 1 Zinc ribbon domain zf-C2H2_6 PF13912.4 MSTRG.26768.3_2 - 0.0021 17.8 29.8 0.003 17.3 0.0 5.6 6 0 0 6 6 6 2 C2H2-type zinc finger XPA_N PF01286.16 MSTRG.26768.3_2 - 0.34 10.8 0.1 0.34 10.8 0.1 3.1 3 0 0 3 3 3 0 XPA protein N-terminal zinc_ribbon_15 PF17032.3 MSTRG.26768.3_2 - 1.6 9.4 8.1 0.42 11.3 1.8 2.3 1 1 2 3 3 3 0 zinc-ribbon family HypA PF01155.17 MSTRG.26768.3_2 - 4.2 7.3 6.0 0.52 10.2 1.0 1.9 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TFIIS_C PF01096.16 MSTRG.26768.3_2 - 5.2 6.9 10.1 17 5.2 0.1 3.6 3 0 0 3 3 3 0 Transcription factor S-II (TFIIS) zf-H2C2_2 PF13465.4 MSTRG.26768.3_3 - 2e-22 78.4 20.6 1e-07 31.9 0.3 4.4 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.26768.3_3 - 8.6e-18 63.6 29.3 4.1e-05 23.7 1.4 5.4 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.26768.3_3 - 1.7e-17 62.4 26.0 7.5e-05 23.1 1.2 5.5 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.26768.3_3 - 7.2e-11 41.6 26.4 1.1e-05 25.0 1.3 4.8 5 0 0 5 5 5 3 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 MSTRG.26768.3_3 - 0.0004 20.3 11.3 0.16 12.0 3.0 3.5 3 0 0 3 3 3 2 Zinc ribbon domain zf-Di19 PF05605.10 MSTRG.26768.3_3 - 0.0006 19.9 14.5 0.24 11.6 1.4 4.0 2 1 2 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.6 MSTRG.26768.3_3 - 0.0011 19.1 19.1 2.5 8.4 0.4 5.3 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding C1_4 PF07975.10 MSTRG.26768.3_3 - 0.0068 16.5 14.6 2.1 8.5 0.2 4.2 1 1 3 4 4 4 1 TFIIH C1-like domain HypA PF01155.17 MSTRG.26768.3_3 - 0.011 15.6 5.6 0.47 10.4 0.6 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF3268 PF11672.6 MSTRG.26768.3_3 - 0.015 15.5 4.1 2.2 8.5 0.3 2.2 2 0 0 2 2 2 0 zinc-finger-containing domain zinc_ribbon_15 PF17032.3 MSTRG.26768.3_3 - 0.024 15.3 3.5 3.7 8.2 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon family zf-met PF12874.5 MSTRG.26768.3_3 - 0.034 14.4 24.6 0.075 13.3 0.6 4.9 5 0 0 5 5 5 0 Zinc-finger of C2H2 type TFIIS_C PF01096.16 MSTRG.26768.3_3 - 0.18 11.5 12.8 0.76 9.6 3.0 3.3 3 0 0 3 3 3 0 Transcription factor S-II (TFIIS) zf-C2H2_2 PF12756.5 MSTRG.26768.3_3 - 0.25 11.6 9.6 9.4 6.5 5.4 3.8 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zinc-ribbons_6 PF07191.10 MSTRG.26768.3_3 - 0.28 11.1 9.8 2.3 8.1 1.5 2.9 1 1 1 2 2 2 0 zinc-ribbons zf-AN1 PF01428.14 MSTRG.26768.3_3 - 0.37 10.9 15.9 13 5.9 0.2 4.5 4 0 0 4 4 4 0 AN1-like Zinc finger zf-DNA_Pol PF08996.8 MSTRG.26768.3_3 - 0.8 9.3 6.0 1.2 8.7 0.5 2.2 1 1 1 2 2 2 0 DNA Polymerase alpha zinc finger PyrI_C PF02748.13 MSTRG.26768.3_3 - 0.88 9.4 14.6 1.3 8.9 0.1 4.2 5 0 0 5 5 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain SprT-like PF10263.7 MSTRG.26768.3_3 - 2.9 7.6 9.7 1.9 8.2 1.4 2.2 1 1 1 2 2 2 0 SprT-like family DUF4379 PF14311.4 MSTRG.26768.3_3 - 3.5 7.9 7.5 1.2 9.5 0.9 2.7 2 1 1 3 3 3 0 Probable Zinc-ribbon domain Mut7-C PF01927.14 MSTRG.26768.3_3 - 5.5 7.0 8.3 2.2e+02 1.8 0.0 3.2 2 1 0 2 2 2 0 Mut7-C RNAse domain zf-BED PF02892.13 MSTRG.26768.3_3 - 9.2 6.3 15.8 3 7.8 0.5 4.5 1 1 4 5 5 5 0 BED zinc finger RasGEF PF00617.17 MSTRG.10319.1_1 - 3.9e-49 167.0 0.1 6.3e-49 166.3 0.1 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.18 MSTRG.10319.1_1 - 8e-15 54.8 0.2 4.2e-14 52.5 0.0 2.1 2 0 0 2 2 2 1 RasGEF N-terminal motif Trypsin PF00089.24 MSTRG.1893.1_2 - 2.7e-09 37.0 0.1 4.1e-09 36.5 0.1 1.2 1 0 0 1 1 1 1 Trypsin Trypsin PF00089.24 MSTRG.1893.1_3 - 2.3e-44 151.7 0.2 2.9e-44 151.4 0.2 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 MSTRG.1893.1_3 - 1e-07 32.8 0.0 1.4e-07 32.3 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 MSTRG.1893.1_3 - 0.0029 17.9 0.0 0.0062 16.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) PH PF00169.27 MSTRG.19515.1_2 - 0.0094 16.3 0.0 0.017 15.5 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_3 PF14593.4 MSTRG.19515.1_2 - 0.078 13.0 0.0 0.85 9.6 0.0 2.1 2 0 0 2 2 2 0 PH domain RPAP2_Rtr1 PF04181.11 MSTRG.12161.1_1 - 1.6e-20 73.1 3.0 1.6e-20 73.1 3.0 2.3 3 1 0 3 3 3 1 Rtr1/RPAP2 family AP4E_app_platf PF14807.4 MSTRG.25062.1_1 - 2.9e-35 120.5 0.0 8.7e-35 119.0 0.0 1.9 1 0 0 1 1 1 1 Adaptin AP4 complex epsilon appendage platform Adaptin_N PF01602.18 MSTRG.25062.1_1 - 0.0004 18.9 0.1 0.00054 18.5 0.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Baculo_VP91_N PF08475.8 MSTRG.25062.1_1 - 0.0046 16.5 0.1 0.0082 15.7 0.1 1.3 1 0 0 1 1 1 1 Viral capsid protein 91 N-terminal Aminotran_1_2 PF00155.19 MSTRG.4175.2_3 - 2.4e-88 296.7 0.0 2.8e-88 296.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II NUDE_C PF04880.11 MSTRG.16297.1_1 - 2.1e-09 38.0 0.7 2.1e-09 38.0 0.7 2.6 2 0 0 2 2 2 1 NUDE protein, C-terminal conserved region Striatin PF08232.10 MSTRG.16297.1_1 - 0.13 12.7 0.5 0.17 12.3 0.5 1.2 1 0 0 1 1 1 0 Striatin family ATG16 PF08614.9 MSTRG.16297.1_1 - 0.56 10.2 4.6 0.97 9.4 4.6 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) NUDE_C PF04880.11 MSTRG.16297.1_3 - 2.7e-07 31.1 0.0 6.4e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 NUDE protein, C-terminal conserved region Troponin PF00992.18 MSTRG.22585.1_2 - 5.7e-38 130.1 7.3 5.7e-38 130.1 7.3 1.5 1 1 1 2 2 2 1 Troponin Transposase_22 PF02994.12 MSTRG.22585.1_2 - 0.0022 16.8 3.0 0.0022 16.8 3.0 1.5 1 1 0 1 1 1 1 L1 transposable element Olfactory_mark PF06554.10 MSTRG.11720.2_1 - 0.05 13.2 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Olfactory marker protein BBS2_Mid PF14783.4 MSTRG.17862.2_3 - 7.2e-05 22.7 0.0 0.00018 21.4 0.0 1.7 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, middle region VCBS PF13517.4 MSTRG.17862.2_3 - 0.0006 20.2 3.4 0.0048 17.3 1.8 3.2 2 1 1 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.21 MSTRG.17862.2_3 - 0.63 10.1 5.0 2.1 8.4 5.0 1.9 1 0 0 1 1 1 0 FG-GAP repeat LisH PF08513.9 MSTRG.24076.4_3 - 0.0026 17.6 0.0 0.005 16.6 0.0 1.5 1 0 0 1 1 1 1 LisH ARL2_Bind_BART PF11527.6 MSTRG.18410.1_2 - 6.2e-30 103.6 6.4 8.1e-30 103.2 6.4 1.1 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART Phage_TAC_1 PF06222.9 MSTRG.18410.1_3 - 0.12 12.1 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Phage tail assembly chaperone Spectrin PF00435.19 MSTRG.7864.1_3 - 8.2e-09 35.8 51.4 0.0014 19.0 1.2 8.4 7 3 1 8 8 8 5 Spectrin repeat DUF4132 PF13569.4 MSTRG.7864.1_3 - 0.035 13.8 2.8 0.41 10.3 1.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4132) DltD_M PF04918.10 MSTRG.7864.1_3 - 1.2 9.5 5.1 0.39 11.0 0.4 2.7 2 0 0 2 2 2 0 DltD central region Sugarporin_N PF11471.6 MSTRG.7864.1_3 - 3.9 7.4 6.6 96 2.9 0.1 4.0 3 0 0 3 3 3 0 Maltoporin periplasmic N-terminal extension WD40 PF00400.30 MSTRG.24379.1_2 - 2.3e-24 85.1 11.3 2.3e-08 34.4 0.1 6.9 8 0 0 8 8 8 4 WD domain, G-beta repeat WD40_alt PF14077.4 MSTRG.24379.1_2 - 5.5e-21 74.0 0.0 1.1e-20 73.0 0.0 1.6 1 0 0 1 1 1 1 Alternative WD40 repeat motif ANAPC4_WD40 PF12894.5 MSTRG.24379.1_2 - 2.9e-09 37.0 0.2 0.003 17.7 0.0 4.0 2 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 MSTRG.24379.1_2 - 0.00035 19.2 0.5 0.22 9.9 0.1 2.3 1 1 0 2 2 2 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.3 MSTRG.24379.1_2 - 0.0052 15.7 0.2 0.065 12.1 0.0 2.5 2 1 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein bZIP_1 PF00170.19 MSTRG.24379.1_2 - 0.18 11.8 0.2 0.34 10.9 0.2 1.3 1 0 0 1 1 1 0 bZIP transcription factor Reprolysin PF01421.17 MSTRG.15480.3_3 - 1.3e-55 188.3 0.0 2.7e-55 187.2 0.0 1.6 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 MSTRG.15480.3_3 - 5.9e-26 91.0 2.7 5.9e-26 91.0 2.7 3.6 3 1 1 4 4 2 1 ADAM cysteine-rich Reprolysin_5 PF13688.4 MSTRG.15480.3_3 - 1.2e-18 67.8 0.0 2.9e-18 66.6 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Disintegrin PF00200.21 MSTRG.15480.3_3 - 4.3e-18 65.7 31.1 4.3e-18 65.7 31.1 4.5 4 1 0 4 4 4 1 Disintegrin Pep_M12B_propep PF01562.17 MSTRG.15480.3_3 - 4.9e-17 62.3 0.0 1.1e-16 61.2 0.0 1.6 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_3 PF13582.4 MSTRG.15480.3_3 - 3.7e-15 56.4 0.0 8.7e-15 55.2 0.0 1.6 2 0 0 2 2 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 MSTRG.15480.3_3 - 2e-11 43.8 0.0 3.4e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 MSTRG.15480.3_3 - 5.3e-10 39.4 0.1 1.1e-09 38.4 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.11 MSTRG.15480.3_3 - 0.00055 20.1 14.4 0.00055 20.1 14.4 6.0 7 0 0 7 7 3 1 EGF-like domain Peptidase_M10 PF00413.22 MSTRG.15480.3_3 - 0.0015 18.2 0.0 0.0023 17.6 0.0 1.3 1 0 0 1 1 1 1 Matrixin Peptidase_M57 PF12388.6 MSTRG.15480.3_3 - 0.0026 17.3 0.4 0.0049 16.4 0.4 1.4 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase DUF3152 PF11350.6 MSTRG.15480.3_3 - 0.04 13.5 0.1 0.077 12.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3152) Astacin PF01400.22 MSTRG.15480.3_3 - 0.055 13.0 0.8 0.078 12.4 0.0 1.6 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Peptidase_M54 PF07998.9 MSTRG.15480.3_3 - 0.11 12.3 0.1 0.26 11.1 0.1 1.5 1 0 0 1 1 1 0 Peptidase family M54 GIT_CC PF16559.3 MSTRG.6868.1_1 - 0.035 14.0 0.4 0.061 13.2 0.4 1.4 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor KIAA1430 PF13879.4 MSTRG.6868.1_1 - 0.42 11.3 3.3 0.14 12.8 0.7 1.5 2 0 0 2 2 2 0 KIAA1430 homologue Unstab_antitox PF09720.8 MSTRG.6868.1_3 - 0.14 12.1 0.1 0.24 11.4 0.1 1.3 1 0 0 1 1 1 0 Putative addiction module component GPCR_chapero_1 PF11904.6 MSTRG.12829.1_2 - 1.2e-67 228.4 1.0 1.5e-67 228.1 0.0 1.6 2 0 0 2 2 2 1 GPCR-chaperone Ank_2 PF12796.5 MSTRG.12829.1_2 - 2e-08 34.6 0.0 6.3e-08 33.0 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.12829.1_2 - 1.8e-07 31.2 0.1 1.8e-06 28.0 0.1 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.4 MSTRG.12829.1_2 - 5.7e-07 29.8 0.2 3.6e-06 27.3 0.1 2.5 3 0 0 3 3 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.12829.1_2 - 1e-05 25.4 1.2 0.0087 16.4 0.3 3.2 3 0 0 3 3 2 1 Ankyrin repeat Ank PF00023.28 MSTRG.12829.1_2 - 2.3e-05 24.5 0.6 0.00021 21.5 1.1 2.4 2 0 0 2 2 2 1 Ankyrin repeat Reo_sigmaC PF04582.10 MSTRG.12829.1_2 - 9.8e-05 21.8 14.0 0.00024 20.5 9.0 2.3 1 1 1 2 2 2 2 Reovirus sigma C capsid protein BLOC1_2 PF10046.7 MSTRG.12829.1_2 - 0.0076 16.4 9.1 0.0083 16.3 1.3 2.4 2 0 0 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 MAD PF05557.11 MSTRG.12829.1_2 - 0.016 13.4 7.9 0.024 12.9 7.9 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein ADIP PF11559.6 MSTRG.12829.1_2 - 0.026 14.5 0.2 0.026 14.5 0.2 2.7 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Lzipper-MIP1 PF14389.4 MSTRG.12829.1_2 - 0.15 12.2 0.3 0.53 10.4 0.3 1.9 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 Spc7 PF08317.9 MSTRG.12829.1_2 - 0.17 10.6 12.0 0.027 13.2 2.6 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Cytochrom_B562 PF07361.9 MSTRG.12829.1_2 - 0.18 12.3 6.0 3.8 8.1 1.6 2.7 2 0 0 2 2 2 0 Cytochrome b562 Fib_alpha PF08702.8 MSTRG.12829.1_2 - 0.24 11.4 11.0 2.4 8.2 0.9 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Lebercilin PF15619.4 MSTRG.12829.1_2 - 0.27 10.7 6.9 0.062 12.8 1.4 2.3 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease IncA PF04156.12 MSTRG.12829.1_2 - 0.71 9.5 4.0 0.73 9.5 0.4 2.3 1 1 1 2 2 2 0 IncA protein Baculo_PEP_C PF04513.10 MSTRG.12829.1_2 - 0.71 9.8 7.1 0.84 9.5 5.5 1.9 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Leu_zip PF15294.4 MSTRG.12829.1_2 - 0.89 8.9 6.6 2.1 7.7 6.6 1.5 1 0 0 1 1 1 0 Leucine zipper CC2-LZ PF16516.3 MSTRG.12829.1_2 - 1 9.6 7.0 0.45 10.7 1.8 2.6 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF1664 PF07889.10 MSTRG.12829.1_2 - 1.3 8.9 9.7 3.4 7.5 0.5 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) GAS PF13851.4 MSTRG.12829.1_2 - 4.6 6.4 8.4 2.1 7.5 3.9 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Talin_middle PF09141.8 MSTRG.12829.1_2 - 4.9 7.0 10.2 1.6 8.6 2.6 3.3 3 1 1 4 4 4 0 Talin, middle domain ANF_receptor PF01094.26 MSTRG.16803.1_3 - 0.084 11.8 0.1 0.084 11.8 0.1 1.0 1 0 0 1 1 1 0 Receptor family ligand binding region Calsarcin PF05556.9 MSTRG.388.1_2 - 0.00031 20.2 0.0 0.15 11.4 0.0 2.5 2 1 0 2 2 2 2 Calcineurin-binding protein (Calsarcin) Ferric_reduct PF01794.17 MSTRG.25084.1_2 - 3.5e-09 36.8 7.0 5e-09 36.2 7.0 1.3 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.10 MSTRG.25084.1_2 - 7.3e-08 32.3 0.0 1.3e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain Glyco_transf_22 PF03901.15 MSTRG.25084.1_2 - 0.0049 16.0 6.2 0.0061 15.7 6.2 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family SpoIIE PF07228.10 MSTRG.15168.2_3 - 1.3e-13 51.2 0.0 1.8e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.4 MSTRG.15168.2_3 - 0.0038 16.8 0.0 0.0064 16.0 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.19 MSTRG.15168.2_3 - 0.032 13.7 0.1 0.71 9.3 0.0 2.1 2 0 0 2 2 2 0 Protein phosphatase 2C Ricin_B_lectin PF00652.20 MSTRG.17920.5_1 - 2e-20 73.2 0.0 3.8e-20 72.3 0.0 1.5 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.4 MSTRG.17920.5_1 - 4.5e-05 24.0 0.0 0.028 15.0 0.0 2.5 1 1 0 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Glycos_transf_2 PF00535.24 MSTRG.17920.5_2 - 4.2e-29 101.4 0.0 6.5e-29 100.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.4 MSTRG.17920.5_2 - 6.7e-10 39.1 0.0 1.7e-09 37.8 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.12 MSTRG.17920.5_2 - 0.002 17.6 0.0 0.0037 16.7 0.0 1.3 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 MSTRG.17920.5_2 - 0.05 12.9 0.0 0.092 12.1 0.0 1.4 2 0 0 2 2 2 0 Glycosyltransferase like family 2 Abhydrolase_2 PF02230.14 MSTRG.7872.2_2 - 7.1e-80 267.7 0.1 9.5e-80 267.3 0.1 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase DLH PF01738.16 MSTRG.7872.2_2 - 1.3e-06 28.0 0.0 2e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.11 MSTRG.7872.2_2 - 2.8e-05 23.9 0.0 4.5e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold FSH1 PF03959.11 MSTRG.7872.2_2 - 0.00019 21.0 0.0 0.00046 19.8 0.0 1.6 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Hydrolase_4 PF12146.6 MSTRG.7872.2_2 - 0.00059 19.0 0.0 0.13 11.3 0.0 2.7 2 1 1 3 3 3 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.19 MSTRG.7872.2_2 - 0.00082 18.8 0.0 0.11 11.8 0.0 2.2 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_6 PF12697.5 MSTRG.7872.2_2 - 0.002 18.6 0.0 0.003 18.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2974 PF11187.6 MSTRG.7872.2_2 - 0.0029 17.0 0.0 0.0047 16.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_1 PF00561.18 MSTRG.7872.2_2 - 0.0068 15.9 0.6 0.048 13.1 0.6 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF2920 PF11144.6 MSTRG.7872.2_2 - 0.034 13.2 0.0 2.1 7.3 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2920) CD20 PF04103.13 MSTRG.22046.1_3 - 3.3e-28 98.6 8.5 5.3e-28 97.9 8.5 1.3 1 0 0 1 1 1 1 CD20-like family DUF1129 PF06570.9 MSTRG.22046.1_3 - 0.12 11.7 0.1 0.26 10.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) TcpE PF12648.5 MSTRG.22046.1_3 - 0.15 12.5 3.5 0.41 11.1 3.5 1.8 1 0 0 1 1 1 0 TcpE family 5TM-5TMR_LYT PF07694.10 MSTRG.22046.1_3 - 0.53 9.7 7.1 0.97 8.8 7.1 1.4 1 0 0 1 1 1 0 5TMR of 5TMR-LYT PFU PF09070.9 MSTRG.3337.1_3 - 1.9e-41 140.7 0.3 3.2e-41 140.0 0.3 1.4 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.30 MSTRG.3337.1_3 - 4.8e-40 134.7 8.9 1.9e-06 28.3 0.0 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat PUL PF08324.9 MSTRG.3337.1_3 - 4.1e-33 114.7 0.0 5.4e-33 114.3 0.0 1.2 1 0 0 1 1 1 1 PUL domain BBS2_Mid PF14783.4 MSTRG.3337.1_3 - 0.0017 18.2 0.0 1.1 9.2 0.0 3.2 2 1 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region GAGE PF05831.9 MSTRG.3337.1_3 - 0.23 11.9 0.1 0.43 11.0 0.1 1.4 1 0 0 1 1 1 0 GAGE protein PKD PF00801.18 MSTRG.20235.1_1 - 0.081 12.6 0.1 0.13 12.0 0.1 1.3 1 0 0 1 1 1 0 PKD domain HSP20 PF00011.19 MSTRG.20235.1_3 - 4.6e-14 52.3 0.0 8.3e-14 51.5 0.0 1.4 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Tetraspannin PF00335.18 MSTRG.26269.2_2 - 4.4e-10 39.6 0.3 5.5e-10 39.3 0.3 1.1 1 0 0 1 1 1 1 Tetraspanin family XhlA PF10779.7 MSTRG.10157.1_1 - 0.022 14.8 0.9 0.036 14.1 0.9 1.3 1 0 0 1 1 1 0 Haemolysin XhlA fn3 PF00041.19 MSTRG.11825.1_1 - 2.5e-12 46.8 0.0 4.5e-07 30.0 0.0 2.5 2 1 0 2 2 2 2 Fibronectin type III domain ChitinaseA_N PF08329.8 MSTRG.11825.1_1 - 0.0032 17.0 0.4 2.3 7.7 0.0 2.2 2 0 0 2 2 2 2 Chitinase A, N-terminal domain Pur_ac_phosph_N PF16656.3 MSTRG.11825.1_1 - 0.014 15.8 0.1 1.3 9.5 0.1 2.5 2 1 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain FXa_inhibition PF14670.4 MSTRG.9702.2_1 - 6.2e-05 23.1 4.9 0.00029 20.9 4.9 2.3 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site Ldl_recept_b PF00058.15 MSTRG.9702.2_1 - 0.017 15.4 0.1 0.031 14.6 0.1 1.4 1 0 0 1 1 1 0 Low-density lipoprotein receptor repeat class B Ldl_recept_a PF00057.16 MSTRG.9702.2_2 - 1e-93 307.1 152.5 4.2e-13 49.1 13.1 9.0 8 0 0 8 8 8 8 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.15 MSTRG.9702.2_2 - 4.4e-43 145.4 2.3 3.8e-13 49.6 0.1 4.5 4 0 0 4 4 4 4 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 MSTRG.9702.2_2 - 1.7e-09 37.7 23.8 1.7e-06 28.0 7.6 5.0 5 0 0 5 5 5 2 Coagulation Factor Xa inhibitory site EGF_CA PF07645.13 MSTRG.9702.2_2 - 3.7e-07 30.1 6.8 3.7e-07 30.1 6.8 9.8 5 3 3 8 8 8 2 Calcium-binding EGF domain cEGF PF12662.5 MSTRG.9702.2_2 - 8.4e-07 28.7 9.4 0.0068 16.2 1.4 4.2 2 0 0 2 2 2 2 Complement Clr-like EGF-like SGL PF08450.10 MSTRG.9702.2_2 - 4.7e-05 23.0 0.1 0.12 11.9 0.0 2.4 1 1 1 2 2 2 2 SMP-30/Gluconolaconase/LRE-like region S10_plectin PF03501.13 MSTRG.21658.1_2 - 2.8e-48 161.8 0.2 3.3e-48 161.6 0.2 1.0 1 0 0 1 1 1 1 Plectin/S10 domain DRMBL PF07522.12 MSTRG.15445.2_3 - 6.4e-34 116.5 0.0 1.9e-33 115.0 0.0 1.9 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.5 MSTRG.15445.2_3 - 2.4e-07 30.4 0.1 4.2e-07 29.6 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.25 MSTRG.15445.2_3 - 0.00013 22.0 0.1 0.00027 20.9 0.1 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily CATSPERG PF15064.4 MSTRG.15445.2_3 - 0.033 11.9 0.0 0.046 11.4 0.0 1.1 1 0 0 1 1 1 0 Cation channel sperm-associated protein subunit gamma RMMBL PF07521.10 MSTRG.15445.2_3 - 0.067 13.0 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain Pkinase PF00069.23 MSTRG.20681.1_3 - 1.6e-62 211.1 0.0 4.8e-62 209.6 0.0 1.9 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.20681.1_3 - 3.3e-43 147.7 0.0 3.3e-43 147.7 0.0 2.2 3 0 0 3 3 3 1 Protein tyrosine kinase AAA-ATPase_like PF09820.7 MSTRG.20681.1_3 - 0.0033 16.8 3.4 0.0033 16.8 3.4 2.3 1 1 0 2 2 2 1 Predicted AAA-ATPase NUC130_3NT PF08158.10 MSTRG.20681.1_3 - 0.031 14.5 0.1 0.22 11.8 0.1 2.5 1 0 0 1 1 1 0 NUC130/3NT domain APH PF01636.21 MSTRG.20681.1_3 - 0.039 13.7 0.0 0.039 13.7 0.0 3.4 3 1 0 3 3 3 0 Phosphotransferase enzyme family TcdB_N PF12918.5 MSTRG.20681.1_3 - 2.7 8.2 14.2 5.4 7.3 4.7 4.0 3 0 0 3 3 3 0 TcdB toxin N-terminal helical domain Pkinase PF00069.23 MSTRG.161.3_3 - 6.2e-13 48.6 0.1 7.5e-13 48.3 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.161.3_3 - 2.1e-08 33.6 0.0 2.6e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Cpl-7 PF08230.9 MSTRG.161.3_3 - 1.3 8.7 2.8 1 9.0 1.1 1.6 2 0 0 2 2 2 0 Cpl-7 lysozyme C-terminal domain GKAP PF03359.11 MSTRG.814.3_3 - 1.2e-30 107.2 0.1 1.2e-30 107.2 0.1 2.9 2 1 1 3 3 3 1 Guanylate-kinase-associated protein (GKAP) protein Peptidase_S64 PF08192.9 MSTRG.814.3_3 - 9.6 4.4 12.2 13 3.9 12.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 fn3 PF00041.19 MSTRG.8967.1_2 - 3.1e-16 59.4 0.4 3.9e-10 39.8 0.0 3.3 3 0 0 3 3 3 2 Fibronectin type III domain EpoR_lig-bind PF09067.8 MSTRG.8967.1_2 - 2.4e-11 43.6 0.0 6.8e-11 42.2 0.0 1.7 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding Lep_receptor_Ig PF06328.9 MSTRG.8967.1_2 - 3.1e-09 36.6 0.0 9.9e-09 35.0 0.0 1.9 1 0 0 1 1 1 1 Ig-like C2-type domain IL6Ra-bind PF09240.8 MSTRG.8967.1_2 - 5.6e-08 33.0 0.2 1.7e-07 31.5 0.2 1.9 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding Pur_ac_phosph_N PF16656.3 MSTRG.8967.1_2 - 8.4e-06 26.1 0.1 7.8e-05 23.0 0.0 2.6 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain Tissue_fac PF01108.15 MSTRG.8967.1_2 - 0.00076 19.1 1.2 0.012 15.3 0.1 2.8 2 1 1 3 3 3 1 Tissue factor CBM_21 PF03370.11 MSTRG.4378.2_3 - 1.3e-28 99.3 0.1 2e-28 98.7 0.1 1.3 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.3 MSTRG.4378.2_3 - 3.2e-10 40.3 0.7 3.2e-10 40.3 0.7 1.7 2 0 0 2 2 2 1 Starch/carbohydrate-binding module (family 53) Med12-PQL PF12144.6 MSTRG.7271.5_2 - 5.7e-74 248.4 50.7 5.7e-74 248.4 50.7 6.3 4 2 2 6 6 6 1 Eukaryotic Mediator 12 catenin-binding domain Med12-LCEWAV PF12145.6 MSTRG.7271.5_2 - 1.2e-63 215.5 1.7 1.2e-63 215.5 1.7 3.2 3 1 0 3 3 3 1 Eukaryotic Mediator 12 subunit domain DUF2650 PF10853.6 MSTRG.2388.1_1 - 0.3 10.7 5.7 3.6 7.3 1.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2650) 7tm_1 PF00001.19 MSTRG.76.1_1 - 4.3e-36 124.4 5.4 5e-36 124.2 5.4 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 MSTRG.76.1_1 - 2.4e-05 23.7 5.8 3e-05 23.4 5.8 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 MSTRG.76.1_1 - 0.00056 19.6 1.6 0.00068 19.3 1.6 1.1 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 MSTRG.76.1_1 - 0.0033 16.7 5.1 0.0038 16.5 5.1 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Sigma_1s PF02454.14 MSTRG.76.1_1 - 0.071 13.0 0.0 0.092 12.6 0.0 1.2 1 0 0 1 1 1 0 Sigma 1s protein Herpes_UL52 PF03121.13 MSTRG.27770.1_2 - 5.3e-14 51.8 0.1 1.1e-13 50.7 0.1 1.6 1 0 0 1 1 1 1 Herpesviridae UL52/UL70 DNA primase RasGEF PF00617.17 MSTRG.17724.1_2 - 3.4e-43 147.7 0.4 7.4e-43 146.6 0.4 1.6 1 0 0 1 1 1 1 RasGEF domain C1_1 PF00130.20 MSTRG.17724.1_2 - 7.5e-14 51.2 10.3 1.6e-13 50.2 10.3 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_6 PF13405.4 MSTRG.17724.1_2 - 1.1e-06 27.9 1.0 0.00084 19.0 0.2 3.4 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.30 MSTRG.17724.1_2 - 5e-05 22.4 6.2 0.0044 16.3 0.5 3.3 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.4 MSTRG.17724.1_2 - 7e-05 23.1 1.7 0.021 15.2 0.1 3.3 2 1 0 2 2 2 1 EF-hand domain pair bZIP_2 PF07716.13 MSTRG.17724.1_2 - 0.043 13.8 3.4 0.11 12.4 3.4 1.7 1 0 0 1 1 1 0 Basic region leucine zipper JIP_LZII PF16471.3 MSTRG.17724.1_2 - 0.11 12.5 2.6 0.29 11.2 2.6 1.7 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II EF-hand_5 PF13202.4 MSTRG.17724.1_2 - 0.35 10.4 5.0 0.22 11.0 0.3 2.8 3 0 0 3 3 3 0 EF hand bZIP_1 PF00170.19 MSTRG.17724.1_2 - 0.44 10.6 8.3 2.5 8.1 8.3 2.3 1 1 0 1 1 1 0 bZIP transcription factor ZapB PF06005.10 MSTRG.17724.1_2 - 1.2 9.5 11.5 0.17 12.2 5.0 2.7 4 0 0 4 4 4 0 Cell division protein ZapB IncA PF04156.12 MSTRG.17724.1_2 - 7.7 6.1 8.5 0.97 9.1 1.4 2.5 3 0 0 3 3 3 0 IncA protein V-set PF07686.15 MSTRG.5482.3_3 - 1.5e-06 28.2 0.0 2.8e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 MSTRG.5482.3_3 - 3.3e-05 23.8 0.0 0.00021 21.2 0.0 2.1 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.5482.3_3 - 0.0012 19.2 0.0 0.0025 18.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain DUF4381 PF14316.4 MSTRG.5482.3_3 - 0.0015 18.7 0.0 0.0061 16.7 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4381) LYRIC PF15686.3 MSTRG.5482.3_3 - 0.0047 16.4 0.3 0.0062 16.0 0.3 1.1 1 0 0 1 1 1 1 Lysine-rich CEACAM1 co-isolated protein family FAM176 PF14851.4 MSTRG.5482.3_3 - 0.013 15.1 0.3 0.025 14.1 0.3 1.4 1 0 0 1 1 1 0 FAM176 family V-set_CD47 PF08204.9 MSTRG.5482.3_3 - 0.034 14.0 0.0 0.055 13.3 0.0 1.3 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain CopD PF05425.11 MSTRG.5482.3_3 - 0.05 13.9 0.1 0.05 13.9 0.1 1.9 2 1 0 2 2 2 0 Copper resistance protein D I-set PF07679.14 MSTRG.5482.3_3 - 0.07 13.1 0.0 0.26 11.2 0.0 2.0 2 1 0 2 2 2 0 Immunoglobulin I-set domain Phage_holin_3_6 PF07332.9 MSTRG.5482.3_3 - 0.081 12.8 0.2 0.081 12.8 0.2 2.1 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III DUF4363 PF14276.4 MSTRG.5482.3_3 - 0.085 12.8 0.1 0.12 12.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) MHYT PF03707.14 MSTRG.5482.3_3 - 0.12 12.4 3.1 6.4 6.9 0.1 2.4 2 0 0 2 2 2 0 Bacterial signalling protein N terminal repeat EphA2_TM PF14575.4 MSTRG.5482.3_3 - 0.16 12.7 0.0 0.35 11.6 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Ank_4 PF13637.4 MSTRG.11589.1_3 - 1.1e-34 118.3 12.1 3e-10 40.3 0.2 4.3 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.5 MSTRG.11589.1_3 - 4e-30 104.1 3.6 1.2e-17 64.1 1.2 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 MSTRG.11589.1_3 - 9.1e-28 95.3 4.5 1.4e-07 31.5 0.7 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.4 MSTRG.11589.1_3 - 5.6e-24 83.7 9.0 8.3e-08 32.3 0.3 4.2 2 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.11589.1_3 - 2.5e-22 76.4 5.3 5.2e-07 29.3 0.4 5.4 5 0 0 5 5 5 5 Ankyrin repeat Cgr1 PF03879.12 MSTRG.27764.1_3 - 0.0049 17.1 18.5 0.0049 17.1 18.5 2.5 1 1 1 2 2 2 1 Cgr1 family Cadherin PF00028.15 MSTRG.7328.1_1 - 5.1e-95 312.0 28.1 1.9e-13 50.5 0.1 9.5 9 0 0 9 9 9 9 Cadherin domain Cadherin_2 PF08266.10 MSTRG.7328.1_1 - 3.6e-12 45.8 3.5 0.081 12.6 0.0 7.1 7 1 1 8 8 8 4 Cadherin-like Cadherin_3 PF16184.3 MSTRG.7328.1_1 - 3.8e-11 42.8 23.8 0.19 11.6 1.9 8.8 7 1 2 9 9 9 6 Cadherin-like PapD-like PF14874.4 MSTRG.7328.1_1 - 0.12 12.5 0.0 0.34 11.0 0.0 1.8 1 0 0 1 1 1 0 Flagellar-associated PapD-like He_PIG PF05345.10 MSTRG.7328.1_1 - 5.5 7.1 16.6 14 5.9 0.2 6.0 6 0 0 6 6 6 0 Putative Ig domain Recep_L_domain PF01030.22 MSTRG.20004.1_1 - 2.8e-31 107.8 0.2 3.9e-31 107.3 0.2 1.2 1 0 0 1 1 1 1 Receptor L domain Chi-conotoxin PF16981.3 MSTRG.20004.1_1 - 0.017 15.2 0.0 0.033 14.3 0.0 1.5 1 0 0 1 1 1 0 chi-Conotoxin or t superfamily COLFI PF01410.16 MSTRG.5605.1_2 - 8.4e-70 234.5 0.0 1.1e-69 234.2 0.0 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain BSMAP PF12280.6 MSTRG.23652.1_1 - 1.8e-73 246.5 0.2 2.9e-73 245.8 0.2 1.3 1 0 0 1 1 1 1 Brain specific membrane anchored protein SOUL PF04832.10 MSTRG.9665.2_1 - 5.7e-28 98.0 0.0 7.7e-28 97.6 0.0 1.1 1 0 0 1 1 1 1 SOUL heme-binding protein SOUL PF04832.10 MSTRG.9665.2_2 - 1.9e-11 44.2 0.0 2.9e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 SOUL heme-binding protein PDZ PF00595.22 MSTRG.15148.1_1 - 6.7e-88 289.0 6.8 2.6e-16 59.6 0.1 6.5 6 0 0 6 6 6 6 PDZ domain (Also known as DHR or GLGF) Y_phosphatase PF00102.25 MSTRG.15148.1_1 - 2.1e-76 256.4 0.2 3.3e-76 255.8 0.2 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PDZ_2 PF13180.4 MSTRG.15148.1_1 - 2.3e-31 107.8 3.0 3e-05 24.1 0.0 6.5 6 0 0 6 6 6 5 PDZ domain FERM_M PF00373.16 MSTRG.15148.1_1 - 2.7e-25 88.9 1.1 7.6e-25 87.5 1.1 1.8 1 0 0 1 1 1 1 FERM central domain PTN13_u3 PF16599.3 MSTRG.15148.1_1 - 4.8e-22 78.8 5.2 4.8e-22 78.8 5.2 3.2 3 0 0 3 3 2 1 Unstructured linker region on PTN13 protein between PDZ FERM_C PF09380.8 MSTRG.15148.1_1 - 3.1e-20 72.2 0.4 6.7e-20 71.1 0.4 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.8 MSTRG.15148.1_1 - 2.6e-13 49.6 0.1 1.8e-12 46.9 0.0 2.5 3 0 0 3 3 3 1 FERM N-terminal domain KIND PF16474.3 MSTRG.15148.1_1 - 1.3e-07 31.6 0.2 2.2e-06 27.6 0.0 2.8 2 1 1 3 3 3 1 Kinase non-catalytic C-lobe domain DSPc PF00782.18 MSTRG.15148.1_1 - 0.0035 17.0 0.0 0.0088 15.7 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PUA PF01472.18 MSTRG.15148.1_1 - 0.019 14.8 0.1 0.69 9.8 0.0 2.5 2 0 0 2 2 2 0 PUA domain PTPlike_phytase PF14566.4 MSTRG.15148.1_1 - 0.025 14.6 0.0 0.057 13.4 0.0 1.6 1 0 0 1 1 1 0 Inositol hexakisphosphate MRP-L20 PF12824.5 MSTRG.15148.1_1 - 1.8 8.6 4.7 5.6 7.0 4.7 1.8 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit L20 AAA_12 PF13087.4 MSTRG.21611.2_1 - 2.1e-43 148.1 0.0 3.3e-43 147.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.4 MSTRG.21611.2_1 - 4e-30 105.3 0.0 9.3e-15 54.9 0.0 2.3 1 1 1 2 2 2 2 AAA domain S1-like PF14444.4 MSTRG.21611.2_1 - 5.3e-18 64.7 0.1 3.1e-06 27.0 0.1 3.5 3 0 0 3 3 3 3 S1-like AAA_30 PF13604.4 MSTRG.21611.2_1 - 2.1e-13 50.3 0.0 3.7e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.4 MSTRG.21611.2_1 - 6.6e-07 29.6 0.0 1.3e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.13 MSTRG.21611.2_1 - 1.2e-06 28.5 0.0 2.1e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.19 MSTRG.21611.2_1 - 0.0039 16.6 0.0 0.14 11.5 0.0 2.7 3 0 0 3 3 3 1 UvrD/REP helicase N-terminal domain AAA_22 PF13401.4 MSTRG.21611.2_1 - 0.075 13.2 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.27 MSTRG.21611.2_1 - 0.17 12.2 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PH PF00169.27 MSTRG.25294.1_1 - 5.6e-07 29.9 0.2 4.6e-06 27.0 0.0 2.0 2 0 0 2 2 2 1 PH domain PH_9 PF15410.4 MSTRG.25294.1_1 - 4.4e-05 23.7 0.1 0.00011 22.4 0.0 1.6 2 0 0 2 2 2 1 Pleckstrin homology domain FAM178 PF14816.4 MSTRG.25294.1_1 - 0.069 12.0 1.4 0.075 11.9 1.4 1.1 1 0 0 1 1 1 0 Family of unknown function, FAM178 DUF2615 PF11027.6 MSTRG.11398.1_3 - 1.7e-32 111.5 0.0 2.9e-32 110.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2615) IGFBP PF00219.16 MSTRG.1573.1_3 - 0.01 16.4 0.3 0.01 16.4 0.3 1.6 2 0 0 2 2 2 0 Insulin-like growth factor binding protein UPF0547 PF10571.7 MSTRG.1573.1_3 - 0.068 13.1 0.4 0.13 12.3 0.4 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 Ribosomal_S28e PF01200.16 MSTRG.23475.1_2 - 1e-33 115.0 1.1 1.3e-33 114.6 1.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S28e GYF PF02213.14 MSTRG.6644.1_2 - 1.5e-19 69.3 0.1 2.9e-19 68.4 0.1 1.5 1 0 0 1 1 1 1 GYF domain DUF4339 PF14237.4 MSTRG.6644.1_2 - 0.0095 15.6 0.0 0.0095 15.6 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4339) DUF4574 PF15141.4 MSTRG.6644.1_2 - 0.13 12.1 4.5 0.4 10.5 4.1 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4574) DUF912 PF06024.10 MSTRG.24749.1_3 - 2.9 8.1 3.9 3.7 7.8 3.9 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) PMP22_Claudin PF00822.18 MSTRG.21016.1_1 - 1.3e-20 73.8 4.1 2.1e-20 73.1 4.1 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 MSTRG.21016.1_1 - 0.0096 15.6 4.1 0.015 14.9 4.1 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction RPE65 PF03055.13 MSTRG.16933.1_2 - 6.1e-119 397.8 0.6 8.3e-119 397.3 0.6 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Arf PF00025.19 MSTRG.20140.1_3 - 3.2e-43 147.1 0.0 4.7e-43 146.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 MSTRG.20140.1_3 - 2.5e-08 34.0 0.0 5.2e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 MSTRG.20140.1_3 - 3e-08 33.2 0.0 6.1e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.20 MSTRG.20140.1_3 - 3.7e-08 33.0 0.0 6.3e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Ras family G-alpha PF00503.18 MSTRG.20140.1_3 - 3.6e-07 29.5 0.6 0.00033 19.8 0.0 3.2 2 1 1 3 3 3 2 G-protein alpha subunit MMR_HSR1 PF01926.21 MSTRG.20140.1_3 - 1.5e-05 24.9 0.0 3.1e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase BUD22 PF09073.8 MSTRG.20140.1_3 - 0.027 13.7 15.5 0.035 13.3 15.5 1.1 1 0 0 1 1 1 0 BUD22 AIG1 PF04548.14 MSTRG.19823.2_2 - 4.5e-100 333.2 0.0 3.3e-35 121.2 0.0 3.1 3 0 0 3 3 3 3 AIG1 family MMR_HSR1 PF01926.21 MSTRG.19823.2_2 - 3.6e-14 52.7 0.1 0.0042 17.0 0.0 4.1 3 1 0 3 3 3 3 50S ribosome-binding GTPase Dynamin_N PF00350.21 MSTRG.19823.2_2 - 1.1e-05 25.4 3.4 3.5 7.5 0.0 5.6 3 3 1 5 5 5 1 Dynamin family FtsK_SpoIIIE PF01580.16 MSTRG.19823.2_2 - 8.3e-05 21.9 0.6 3.4 6.8 0.6 3.6 4 0 0 4 4 4 2 FtsK/SpoIIIE family Roc PF08477.11 MSTRG.19823.2_2 - 0.00038 20.6 0.5 9.7 6.3 0.1 3.7 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.19823.2_2 - 0.00067 19.0 0.1 0.014 14.7 0.0 2.7 2 0 0 2 2 2 1 ADP-ribosylation factor family DUF258 PF03193.14 MSTRG.19823.2_2 - 0.0016 18.2 1.9 0.88 9.3 0.1 3.8 6 0 0 6 6 6 1 Protein of unknown function, DUF258 FeoB_N PF02421.16 MSTRG.19823.2_2 - 0.0042 16.5 0.0 0.65 9.4 0.0 2.9 3 0 0 3 3 3 1 Ferrous iron transport protein B CLP1_P PF16575.3 MSTRG.19823.2_2 - 0.0048 16.6 1.5 5.7 6.6 0.0 4.4 4 0 0 4 4 4 1 mRNA cleavage and polyadenylation factor CLP1 P-loop tRNA-synt_1c PF00749.19 MSTRG.19823.2_2 - 0.0089 14.8 0.7 2.8 6.6 0.6 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (E and Q), catalytic domain Ras PF00071.20 MSTRG.19823.2_2 - 0.01 15.3 0.4 0.72 9.3 0.0 3.0 3 0 0 3 3 3 0 Ras family Gtr1_RagA PF04670.10 MSTRG.19823.2_2 - 0.01 15.1 2.1 1.7 7.8 0.0 4.6 5 0 0 5 5 5 0 Gtr1/RagA G protein conserved region ABC_tran PF00005.25 MSTRG.19823.2_2 - 0.011 16.1 1.0 1.7 9.0 0.1 3.8 2 1 0 3 3 3 0 ABC transporter SRPRB PF09439.8 MSTRG.19823.2_2 - 0.011 15.0 0.0 0.21 10.9 0.0 2.7 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.4 MSTRG.19823.2_2 - 0.016 15.1 4.4 4.5 7.2 0.0 4.2 4 1 0 4 4 4 0 AAA domain AAA_24 PF13479.4 MSTRG.19823.2_2 - 0.033 13.8 0.6 7.3 6.1 0.0 3.9 4 1 0 4 4 4 0 AAA domain PduV-EutP PF10662.7 MSTRG.19823.2_2 - 0.035 13.7 0.2 11 5.6 0.0 3.5 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation G-alpha PF00503.18 MSTRG.19823.2_2 - 0.048 12.7 4.7 0.53 9.3 0.1 3.6 3 1 0 4 4 4 0 G-protein alpha subunit CDO_I PF05995.10 MSTRG.1952.2_1 - 1.4e-63 213.1 0.2 1.8e-63 212.7 0.2 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.10 MSTRG.1952.2_1 - 0.0058 16.0 0.5 0.014 14.7 0.4 1.6 1 1 0 1 1 1 1 PCO_ADO DASH_Dad4 PF08650.8 MSTRG.1952.2_1 - 0.099 12.5 0.3 0.24 11.2 0.3 1.6 1 0 0 1 1 1 0 DASH complex subunit Dad4 LRRFIP PF09738.7 MSTRG.9164.5_2 - 2.1e-12 47.1 17.1 2.1e-12 47.1 17.1 1.9 2 1 0 2 2 2 1 LRRFIP family Period_C PF12114.6 MSTRG.12658.1_1 - 1.5e-68 230.2 9.2 1.5e-68 230.2 9.2 2.8 3 0 0 3 3 3 2 Period protein 2/3C-terminal region RAP1 PF07218.9 MSTRG.12658.1_1 - 2.1 6.4 10.6 3.4 5.7 10.6 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Rax2 PF12768.5 MSTRG.10239.2_3 - 0.17 11.3 0.1 0.27 10.7 0.1 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity RhoGEF PF00621.18 MSTRG.7585.2_1 - 1.9e-44 151.9 0.1 3.9e-44 150.9 0.1 1.5 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 MSTRG.7585.2_1 - 0.00022 21.6 0.0 0.00064 20.1 0.0 1.8 1 0 0 1 1 1 1 PH domain PH_10 PF15411.4 MSTRG.7585.2_1 - 0.0042 17.2 0.0 0.0099 16.0 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_13 PF16652.3 MSTRG.7585.2_1 - 0.13 12.0 0.1 0.31 10.8 0.1 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain COX6B PF02297.15 MSTRG.20610.1_2 - 3.9e-16 58.9 8.6 5.3e-16 58.5 8.6 1.2 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb DDE_Tnp_1_2 PF13586.4 MSTRG.20610.1_2 - 0.049 13.9 0.0 0.086 13.1 0.0 1.4 1 0 0 1 1 1 0 Transposase DDE domain CHCH PF06747.11 MSTRG.20610.1_2 - 0.065 13.3 5.5 0.19 11.7 5.5 1.9 1 1 0 1 1 1 0 CHCH domain Pet191_N PF10203.7 MSTRG.20610.1_2 - 0.083 13.1 3.2 0.13 12.4 3.2 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Kinesin PF00225.21 MSTRG.6616.2_3 - 4.4e-07 29.0 0.0 8.1e-07 28.1 0.0 1.5 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 MSTRG.6616.2_3 - 7.6e-05 22.6 0.0 0.00012 21.9 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding BCS1_N PF08740.9 MSTRG.9193.1_2 - 6.5e-46 156.5 2.9 9.3e-46 156.0 2.9 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.27 MSTRG.9193.1_2 - 1.6e-19 70.5 0.0 2.6e-19 69.8 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 MSTRG.9193.1_2 - 0.0027 17.9 0.6 0.02 15.1 0.0 2.0 1 1 1 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.20 MSTRG.9193.1_2 - 0.0038 17.4 0.0 0.0095 16.2 0.0 1.6 2 0 0 2 2 2 1 RNA helicase AAA_33 PF13671.4 MSTRG.9193.1_2 - 0.0085 16.1 0.0 0.098 12.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.12 MSTRG.9193.1_2 - 0.01 15.7 0.0 0.022 14.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Rad17 PF03215.13 MSTRG.9193.1_2 - 0.011 14.6 0.0 0.017 13.9 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_25 PF13481.4 MSTRG.9193.1_2 - 0.014 14.8 0.0 0.027 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.11 MSTRG.9193.1_2 - 0.015 14.3 0.0 0.026 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ABC_tran PF00005.25 MSTRG.9193.1_2 - 0.052 13.9 0.0 0.1 13.0 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.4 MSTRG.9193.1_2 - 0.068 13.5 0.0 0.15 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.4 MSTRG.9193.1_2 - 0.071 12.7 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RuvB_N PF05496.10 MSTRG.9193.1_2 - 0.11 11.5 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus E1-E2_ATPase PF00122.18 MSTRG.6423.1_1 - 8.4e-66 221.3 3.4 1.3e-65 220.7 2.1 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_N PF00690.24 MSTRG.6423.1_1 - 2.4e-20 71.8 0.2 2.4e-19 68.6 0.0 2.3 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.4 MSTRG.6423.1_1 - 1.4e-05 24.9 0.1 3.2e-05 23.8 0.1 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) GoLoco PF02188.15 MSTRG.24976.2_3 - 1.7e-33 113.5 18.3 1.5e-10 40.2 4.0 4.5 4 0 0 4 4 4 3 GoLoco motif TPR_1 PF00515.26 MSTRG.24976.2_3 - 8.3e-16 56.9 6.5 1.4e-05 24.5 0.7 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.24976.2_3 - 2.1e-14 53.4 7.4 2.1e-08 34.2 1.4 2.3 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.24976.2_3 - 4.4e-14 51.2 6.8 6.7e-05 22.5 0.4 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.24976.2_3 - 2.8e-13 48.8 2.8 0.00068 19.5 0.2 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.24976.2_3 - 3e-10 39.3 7.9 7.2e-05 22.5 1.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.24976.2_3 - 1.7e-09 37.1 6.3 0.0021 17.8 0.5 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.24976.2_3 - 0.00018 22.0 1.1 0.0016 19.0 0.5 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_4 PF07721.12 MSTRG.24976.2_3 - 0.0011 19.3 0.4 4.3 8.1 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat UreE_C PF05194.10 MSTRG.24976.2_3 - 0.013 15.8 0.5 0.76 10.2 0.1 2.4 1 1 1 2 2 2 0 UreE urease accessory protein, C-terminal domain TPR_14 PF13428.4 MSTRG.24976.2_3 - 0.026 15.2 0.5 55 4.8 0.1 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.24976.2_3 - 0.037 13.6 5.0 1 8.9 0.1 4.0 4 1 1 5 5 5 0 TPR repeat TOM20_plant PF06552.10 MSTRG.24976.2_3 - 0.11 12.1 0.3 2 8.0 0.0 2.3 1 1 0 2 2 2 0 Plant specific mitochondrial import receptor subunit TOM20 ANAPC3 PF12895.5 MSTRG.24976.2_3 - 0.52 10.4 4.4 2.6 8.2 2.2 2.4 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Y_phosphatase PF00102.25 MSTRG.17203.3_1 - 4.5e-60 203.0 0.1 1.3e-59 201.5 0.0 1.8 2 0 0 2 2 2 1 Protein-tyrosine phosphatase DSPc PF00782.18 MSTRG.17203.3_1 - 0.00087 19.0 0.1 0.0018 17.9 0.1 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PRY PF13765.4 MSTRG.285.1_1 - 7.1e-15 54.2 0.0 1.7e-14 53.1 0.0 1.7 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 MSTRG.285.1_1 - 1.3e-12 47.8 0.0 3.2e-12 46.5 0.0 1.6 2 0 0 2 2 2 1 SPRY domain zf-B_box PF00643.22 MSTRG.285.1_1 - 5.8e-10 39.0 3.5 1.8e-09 37.4 0.1 2.8 3 0 0 3 3 3 1 B-box zinc finger MbeB_N PF04837.10 MSTRG.285.1_1 - 0.075 13.2 1.5 0.22 11.7 1.5 1.8 1 0 0 1 1 1 0 MbeB-like, N-term conserved region Phasin PF05597.9 MSTRG.285.1_1 - 0.13 12.1 3.5 0.23 11.4 3.5 1.3 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF4200 PF13863.4 MSTRG.285.1_1 - 0.23 11.7 13.2 0.4 10.9 13.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) AA_permease PF00324.19 MSTRG.7037.1_3 - 6.5e-58 196.4 28.6 1.4e-37 129.3 3.0 2.1 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.13 MSTRG.7037.1_3 - 2.2e-21 76.2 0.7 1.2e-12 47.5 0.0 2.4 1 1 1 2 2 2 2 Solute carrier family 12 AA_permease_2 PF13520.4 MSTRG.7037.1_3 - 8e-19 67.6 31.6 2.4e-17 62.8 10.4 2.1 2 0 0 2 2 2 2 Amino acid permease zf-C2H2 PF00096.24 MSTRG.8926.1_3 - 3.3e-09 36.5 9.6 0.0002 21.5 0.9 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.8926.1_3 - 6.3e-07 29.4 1.1 6.3e-07 29.4 1.1 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.8926.1_3 - 0.00029 21.3 10.7 0.099 13.4 1.2 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.8926.1_3 - 0.00046 20.3 6.9 0.069 13.4 0.6 2.7 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 MSTRG.8926.1_3 - 0.67 9.6 6.5 1.1 8.9 0.7 2.5 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_7 PF15269.4 MSTRG.8926.1_3 - 1.3 9.0 6.6 3.7 7.6 1.1 2.6 1 1 1 2 2 2 0 Zinc-finger zf-met PF12874.5 MSTRG.8926.1_3 - 2.4 8.5 9.1 1.8 8.9 0.8 2.9 2 0 0 2 2 2 0 Zinc-finger of C2H2 type OAR PF03826.15 MSTRG.368.1_2 - 4e-09 35.9 5.0 8.5e-09 34.8 5.0 1.6 1 0 0 1 1 1 1 OAR domain zf-piccolo PF05715.11 MSTRG.13900.1_3 - 1.4e-55 185.1 34.8 1.2e-28 98.9 16.0 2.5 2 0 0 2 2 2 2 Piccolo Zn-finger FYVE_2 PF02318.14 MSTRG.13900.1_3 - 3e-10 40.2 18.7 8.7e-06 25.8 6.7 2.2 2 0 0 2 2 2 2 FYVE-type zinc finger OrfB_Zn_ribbon PF07282.9 MSTRG.13900.1_3 - 2.4 8.0 17.2 11 5.9 4.0 3.7 2 2 1 3 3 3 0 Putative transposase DNA-binding domain RRM_1 PF00076.20 MSTRG.20799.1_2 - 4.5e-11 42.3 0.0 0.011 15.4 0.0 4.3 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Glyco_hydro_99 PF16317.3 MSTRG.8786.1_2 - 6e-05 22.2 1.8 7.8e-05 21.8 1.8 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 99 SNARE PF05739.17 MSTRG.22651.1_1 - 2.3 8.2 3.8 3.6 7.5 3.8 1.4 1 0 0 1 1 1 0 SNARE domain HemY_N PF07219.11 MSTRG.22651.1_3 - 0.074 13.1 0.2 0.084 12.9 0.2 1.1 1 0 0 1 1 1 0 HemY protein N-terminus SARAF PF06682.10 MSTRG.22651.1_3 - 0.11 12.0 0.0 0.11 12.0 0.0 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis FANCM-MHF_bd PF16783.3 MSTRG.18349.1_3 - 5.4e-41 139.2 0.4 1.9e-40 137.4 0.4 2.0 2 0 0 2 2 2 1 FANCM to MHF binding domain Helicase_C PF00271.29 MSTRG.18349.1_3 - 2.8e-19 69.4 0.1 8.1e-19 67.9 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.27 MSTRG.18349.1_3 - 1.6e-05 24.6 0.0 3.6e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.13 MSTRG.18349.1_3 - 0.00018 21.4 0.0 0.00044 20.2 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HHH_5 PF14520.4 MSTRG.18349.1_3 - 0.11 13.0 0.0 0.33 11.5 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain FYVE PF01363.19 MSTRG.23738.1_3 - 4.4e-16 58.7 15.2 1.6e-15 56.9 15.2 2.0 1 0 0 1 1 1 1 FYVE zinc finger RUN PF02759.17 MSTRG.23738.1_3 - 8.2e-08 32.2 1.4 4e-07 29.9 0.0 2.8 2 0 0 2 2 2 1 RUN domain GOLD_2 PF13897.4 MSTRG.23738.1_3 - 7.3e-05 23.2 0.0 7.3e-05 23.2 0.0 4.9 4 1 0 4 4 4 1 Golgi-dynamics membrane-trafficking Reo_sigmaC PF04582.10 MSTRG.23738.1_3 - 0.0035 16.7 4.7 0.0035 16.7 4.7 7.3 1 1 6 8 8 8 5 Reovirus sigma C capsid protein ECSCR PF15820.3 MSTRG.4103.1_3 - 0.28 10.9 2.5 0.45 10.2 2.5 1.3 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator zf-H2C2_5 PF13909.4 MSTRG.16155.1_2 - 2.4e-08 33.5 14.2 4.1e-06 26.3 3.0 3.6 3 0 0 3 3 3 2 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.4 MSTRG.16155.1_2 - 3.3e-08 33.5 16.0 9.6e-08 32.0 2.0 4.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.16155.1_2 - 3.4e-06 27.1 14.5 6.7e-06 26.1 4.0 3.9 4 0 0 4 4 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.16155.1_2 - 0.0012 19.3 3.0 0.0012 19.3 3.0 4.2 4 0 0 4 4 3 2 C2H2-type zinc finger zf-Di19 PF05605.10 MSTRG.16155.1_2 - 0.0018 18.4 13.3 0.025 14.7 1.3 3.6 2 1 1 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding DUF3268 PF11672.6 MSTRG.16155.1_2 - 0.0056 16.9 1.0 0.01 16.0 1.0 1.4 1 0 0 1 1 1 1 zinc-finger-containing domain DZR PF12773.5 MSTRG.16155.1_2 - 0.007 16.2 0.4 0.014 15.2 0.4 1.5 1 0 0 1 1 1 1 Double zinc ribbon GAGA PF09237.9 MSTRG.16155.1_2 - 0.0081 15.8 2.9 0.44 10.3 0.3 2.4 1 1 1 2 2 2 2 GAGA factor zf-C2H2_jaz PF12171.6 MSTRG.16155.1_2 - 0.03 14.5 2.6 0.16 12.2 0.3 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding CpXC PF14353.4 MSTRG.16155.1_2 - 0.032 14.1 2.9 6 6.8 3.1 2.4 1 1 1 2 2 2 0 CpXC protein zf-CHCC PF10276.7 MSTRG.16155.1_2 - 1.7 8.7 5.3 1.8 8.5 0.4 2.6 2 0 0 2 2 2 0 Zinc-finger domain FAM176 PF14851.4 MSTRG.16155.1_2 - 3.7 7.1 5.2 12 5.5 5.2 1.8 1 0 0 1 1 1 0 FAM176 family Zn_Tnp_IS1595 PF12760.5 MSTRG.16155.1_2 - 4 7.4 6.1 14 5.6 6.2 1.8 1 1 1 2 2 2 0 Transposase zinc-ribbon domain PBP1_TM PF14812.4 MSTRG.16155.1_2 - 4.5 7.6 10.6 7.9 6.9 8.1 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SelP_N PF04592.12 MSTRG.16155.1_3 - 1.6 7.9 11.5 2.4 7.4 11.5 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Actin PF00022.17 MSTRG.11828.4_2 - 1.5e-82 277.3 0.0 3.4e-82 276.1 0.0 1.5 1 1 0 1 1 1 1 Actin Actin PF00022.17 MSTRG.11828.4_3 - 2e-148 494.2 0.0 4.8e-148 493.0 0.0 1.6 1 1 0 1 1 1 1 Actin Trypsin PF00089.24 MSTRG.690.1_3 - 1.5e-30 106.5 0.0 2.4e-30 105.9 0.0 1.3 1 0 0 1 1 1 1 Trypsin Gla PF00594.18 MSTRG.690.1_3 - 1.4e-09 37.9 0.2 2.5e-09 37.0 0.2 1.4 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FXa_inhibition PF14670.4 MSTRG.690.1_3 - 3e-09 36.9 18.9 3.3e-07 30.3 6.3 2.9 1 1 1 2 2 2 2 Coagulation Factor Xa inhibitory site hEGF PF12661.5 MSTRG.690.1_3 - 1.9e-07 31.3 13.7 2.2e-05 24.8 3.6 3.4 2 0 0 2 2 2 2 Human growth factor-like EGF EGF PF00008.25 MSTRG.690.1_3 - 2.4e-07 30.8 16.9 2.9e-06 27.3 5.1 3.0 2 0 0 2 2 2 2 EGF-like domain EGF_CA PF07645.13 MSTRG.690.1_3 - 5.6e-05 23.1 24.4 0.0017 18.4 11.2 3.3 1 1 1 2 2 2 1 Calcium-binding EGF domain Trypsin_2 PF13365.4 MSTRG.690.1_3 - 0.00015 22.5 0.0 0.00035 21.4 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain EGF_3 PF12947.5 MSTRG.690.1_3 - 0.018 15.1 4.9 0.018 15.1 4.9 3.2 2 1 1 3 3 3 0 EGF domain cEGF PF12662.5 MSTRG.690.1_3 - 0.023 14.5 17.1 0.13 12.1 0.3 3.8 2 1 1 3 3 3 0 Complement Clr-like EGF-like Myosin_head PF00063.19 MSTRG.8811.1_1 - 3e-49 167.8 0.3 3.2e-49 167.6 0.3 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) Ribosomal_L14 PF00238.17 MSTRG.24154.2_1 - 4.7e-34 116.9 0.2 6.1e-34 116.6 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Thioredoxin PF00085.18 MSTRG.15788.1_3 - 4e-11 42.6 0.0 7.2e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Crp PF00325.18 MSTRG.6140.1_3 - 0.61 9.7 2.2 0.66 9.6 0.8 1.7 2 0 0 2 2 2 0 Bacterial regulatory proteins, crp family Not1 PF04054.13 MSTRG.2413.2_1 - 1.7e-154 514.1 7.5 3.1e-154 513.2 7.5 1.5 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.3 MSTRG.2413.2_1 - 7.6e-94 313.1 10.5 7.6e-94 313.1 10.5 2.3 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain CNOT1_TTP_bind PF16417.3 MSTRG.2413.2_1 - 4.2e-82 273.8 0.1 1.4e-81 272.1 0.1 1.9 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT PF16418.3 MSTRG.2413.2_1 - 1.1e-53 181.2 0.0 2.8e-53 179.9 0.0 1.8 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 HEAT repeat DUF3819 PF12842.5 MSTRG.2413.2_1 - 2e-52 176.9 6.8 2e-52 176.9 6.8 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3819) EF-hand_8 PF13833.4 MSTRG.2413.2_3 - 0.065 12.9 0.1 0.17 11.6 0.1 1.6 1 1 0 1 1 1 0 EF-hand domain pair PI3K_rbd PF00794.16 MSTRG.4725.1_3 - 1.3e-32 111.9 0.4 1.9e-32 111.4 0.4 1.2 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain PI3K_p85B PF02192.14 MSTRG.4725.1_3 - 1.4e-15 56.6 0.0 2.6e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 PI3-kinase family, p85-binding domain PI3K_C2 PF00792.22 MSTRG.4725.1_3 - 0.00054 19.9 0.0 0.0012 18.8 0.0 1.6 2 0 0 2 2 2 1 Phosphoinositide 3-kinase C2 HAP1_N PF04849.11 MSTRG.21441.1_1 - 7.4e-130 432.5 35.4 9.7e-130 432.2 35.4 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Milton PF12448.6 MSTRG.21441.1_1 - 3.7e-56 189.9 7.2 3.7e-56 189.9 7.2 3.2 2 1 0 2 2 2 1 Kinesin associated protein HOOK PF05622.10 MSTRG.21441.1_1 - 0.11 10.5 27.5 0.18 9.8 27.5 1.3 1 0 0 1 1 1 0 HOOK protein KASH_CCD PF14662.4 MSTRG.21441.1_1 - 1.2 8.8 39.6 1.9 8.2 10.0 3.1 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH MCPsignal PF00015.19 MSTRG.21441.1_1 - 1.7 8.3 6.2 8.4 6.0 3.3 2.2 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain TMF_TATA_bd PF12325.6 MSTRG.21441.1_1 - 1.7 8.8 37.4 0.12 12.5 18.8 3.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding IncA PF04156.12 MSTRG.21441.1_1 - 2.6 7.7 46.5 1.5 8.4 5.7 3.3 2 1 1 3 3 3 0 IncA protein SH3BP5 PF05276.12 MSTRG.21441.1_1 - 3.1 7.4 22.8 0.58 9.8 16.3 2.1 2 0 0 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) GIT_CC PF16559.3 MSTRG.21441.1_1 - 4.7 7.2 17.0 1.8 8.5 0.1 4.2 3 1 1 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor Caskin-Pro-rich PF16907.3 MSTRG.5300.2_2 - 2.6e-36 123.9 6.3 2.6e-36 123.9 6.3 3.7 3 0 0 3 3 3 1 Proline rich region of Caskin proteins Ank_2 PF12796.5 MSTRG.5300.2_2 - 9.4e-36 122.1 5.7 9.2e-13 48.5 0.1 3.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) SAM_1 PF00536.28 MSTRG.5300.2_2 - 4e-34 116.7 0.0 3.3e-16 59.4 0.1 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) Ank_4 PF13637.4 MSTRG.5300.2_2 - 5.3e-31 106.5 5.0 4.7e-06 26.9 0.0 5.7 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.4 MSTRG.5300.2_2 - 9.5e-31 105.2 7.9 6.6e-11 42.1 0.2 5.9 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.5300.2_2 - 1.3e-30 104.4 12.1 2.7e-07 30.6 0.3 6.8 6 0 0 6 6 6 6 Ankyrin repeat Caskin-tail PF16632.3 MSTRG.5300.2_2 - 2.2e-29 101.5 5.1 5.5e-29 100.2 5.1 1.8 1 0 0 1 1 1 1 C-terminal region of Caskin SAM_2 PF07647.15 MSTRG.5300.2_2 - 2.5e-29 101.1 0.0 2.9e-14 52.8 0.1 2.6 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) Ank_3 PF13606.4 MSTRG.5300.2_2 - 1.1e-25 86.7 3.9 6.4e-05 22.9 0.1 7.0 6 0 0 6 6 6 6 Ankyrin repeat Caskin1-CID PF16600.3 MSTRG.5300.2_2 - 2.3e-07 31.2 4.8 2.3e-07 31.2 4.8 5.7 7 1 1 8 8 4 1 Caskin1 CASK-interaction domain SH3_2 PF07653.15 MSTRG.5300.2_2 - 4.1e-06 26.3 0.0 8.6e-06 25.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 MSTRG.5300.2_2 - 7.9e-05 22.3 0.0 0.00022 20.9 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.5300.2_2 - 0.0051 16.2 0.0 0.011 15.2 0.0 1.5 1 0 0 1 1 1 1 SH3 domain RNB PF00773.17 MSTRG.5967.2_1 - 4.7e-68 229.8 0.0 7.3e-68 229.2 0.0 1.2 1 0 0 1 1 1 1 RNB domain Rrp44_CSD1 PF17216.1 MSTRG.5967.2_1 - 3.4e-07 30.0 0.0 6.1e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Rrp44-like cold shock domain RNB PF00773.17 MSTRG.5967.2_2 - 2.5e-11 43.4 0.2 4.3e-11 42.6 0.2 1.3 1 0 0 1 1 1 1 RNB domain Rrp44_S1 PF17215.1 MSTRG.5967.2_2 - 0.0047 16.7 0.0 0.0096 15.7 0.0 1.5 1 0 0 1 1 1 1 S1 domain TauD PF02668.14 MSTRG.2740.1_2 - 6.6e-36 124.3 0.6 9.2e-36 123.8 0.6 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.10 MSTRG.2740.1_2 - 3.8e-08 33.7 0.1 1.1e-07 32.2 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF971) CsiD PF08943.8 MSTRG.2740.1_2 - 0.0072 15.3 0.0 0.015 14.3 0.0 1.4 1 0 0 1 1 1 1 CsiD DUF4525 PF15027.4 MSTRG.6796.1_1 - 7.3e-51 171.4 0.1 1.1e-50 170.8 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4525) PetM PF08041.9 MSTRG.6796.1_1 - 1.6 8.3 5.1 3.9 7.0 5.1 1.6 1 0 0 1 1 1 0 PetM family of cytochrome b6f complex subunit 7 MAPEG PF01124.16 MSTRG.5144.1_2 - 1.5e-22 79.8 0.1 2.8e-22 78.9 0.1 1.5 1 0 0 1 1 1 1 MAPEG family ETRAMP PF09716.8 MSTRG.5144.1_2 - 0.15 12.1 4.5 7.6 6.5 0.3 2.6 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) PB1 PF00564.22 MSTRG.26048.2_2 - 8.5e-09 35.1 0.0 1.4e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 PB1 domain DUF1462 PF07315.9 MSTRG.26048.2_2 - 0.084 13.0 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1462) zf-H2C2_2 PF13465.4 MSTRG.13705.1_2 - 9.7e-38 126.8 49.3 3.8e-09 36.5 0.5 7.7 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.13705.1_2 - 1.2e-33 113.5 49.7 6.5e-06 26.2 0.3 7.8 7 0 0 7 7 7 7 Zinc finger, C2H2 type BTB PF00651.29 MSTRG.13705.1_2 - 1.2e-26 92.9 3.2 2.7e-26 91.8 0.4 2.3 2 0 0 2 2 2 1 BTB/POZ domain zf-C2H2_4 PF13894.4 MSTRG.13705.1_2 - 4.9e-20 70.4 48.6 0.00065 20.2 0.3 7.9 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.13705.1_2 - 9.3e-15 54.0 44.0 0.00078 19.2 0.2 7.8 7 0 0 7 7 7 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.13705.1_2 - 1.4e-13 50.6 27.9 0.099 12.9 1.8 7.8 7 0 0 7 7 7 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.13705.1_2 - 1.9e-13 50.2 36.9 0.002 18.3 1.7 8.0 7 0 0 7 7 7 6 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.8 MSTRG.13705.1_2 - 0.00017 21.5 25.8 0.066 13.2 1.5 5.2 3 1 2 5 5 5 2 Zinc ribbon domain zf-C2H2_11 PF16622.3 MSTRG.13705.1_2 - 0.0067 16.0 31.2 0.55 9.9 1.0 6.2 6 0 0 6 6 6 4 zinc-finger C2H2-type GAGA PF09237.9 MSTRG.13705.1_2 - 0.0097 15.6 7.8 0.31 10.8 0.1 4.5 3 2 1 5 5 5 1 GAGA factor Ta0938 PF11494.6 MSTRG.13705.1_2 - 0.091 12.9 8.5 0.15 12.2 0.3 3.5 1 1 2 3 3 3 0 Ta0938 zinc_ribbon_15 PF17032.3 MSTRG.13705.1_2 - 0.21 12.2 19.3 1.3 9.7 0.5 4.4 1 1 3 5 5 5 0 zinc-ribbon family DUF3268 PF11672.6 MSTRG.13705.1_2 - 0.96 9.7 17.4 3.5 7.8 0.4 4.2 4 1 1 5 5 5 0 zinc-finger-containing domain CTP_transf_like PF01467.24 MSTRG.10419.1_2 - 6.3e-21 74.9 0.0 7.1e-21 74.8 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like His_Phos_1 PF00300.20 MSTRG.18389.1_3 - 8.4e-34 116.8 0.6 7.9e-32 110.4 0.1 2.2 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) DUF3504 PF12012.6 MSTRG.13927.2_3 - 4.4e-54 182.6 1.1 1.9e-53 180.6 1.1 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3504) CopK PF11525.6 MSTRG.13927.2_3 - 0.00056 19.4 3.2 4.7 6.8 0.2 4.5 1 1 4 5 5 5 4 Copper resistance protein K Sarcoglycan_1 PF04790.11 MSTRG.13927.2_3 - 0.0027 17.0 8.9 0.029 13.6 4.9 2.3 1 1 1 2 2 2 2 Sarcoglycan complex subunit protein DUF2345 PF10106.7 MSTRG.13927.2_3 - 0.0039 17.0 24.1 0.089 12.6 5.2 3.7 2 1 2 4 4 4 3 Uncharacterized protein conserved in bacteria (DUF2345) DUF2917 PF11142.6 MSTRG.13927.2_3 - 0.0045 16.2 10.9 2.7 7.4 0.1 5.7 2 2 4 6 6 6 2 Protein of unknown function (DUF2917) DUF1498 PF07385.10 MSTRG.13927.2_3 - 0.0048 16.0 9.3 0.43 9.7 0.8 3.6 1 1 3 4 4 4 3 Protein of unknown function (DUF1498) S-layer PF07752.9 MSTRG.13927.2_3 - 0.075 11.9 0.2 46 2.8 0.0 3.0 1 1 2 3 3 3 0 S-layer protein DUF4261 PF14080.4 MSTRG.13927.2_3 - 9.5 6.3 9.3 62 3.7 0.1 4.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4261) Pro_isomerase PF00160.19 MSTRG.17881.1_1 - 1.2e-48 165.2 0.1 1.8e-48 164.7 0.1 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.26 MSTRG.17881.1_1 - 7.1e-10 38.1 3.8 0.0011 18.6 0.2 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.17881.1_1 - 9e-10 37.8 3.9 0.029 14.3 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.17881.1_1 - 0.00015 21.2 1.4 0.04 13.5 0.1 3.1 2 1 1 3 3 3 1 TPR repeat DUF3856 PF12968.5 MSTRG.17881.1_1 - 0.0014 18.6 0.4 2.1 8.3 0.0 3.1 2 1 0 2 2 2 1 Domain of Unknown Function (DUF3856) TPR_9 PF13371.4 MSTRG.17881.1_1 - 0.0025 17.8 0.3 0.0096 15.9 0.1 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.17881.1_1 - 0.023 15.1 1.7 0.081 13.3 1.5 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.17881.1_1 - 0.025 14.6 0.6 2.4 8.5 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.17881.1_1 - 0.027 14.4 1.5 18 5.6 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.17881.1_1 - 0.031 14.4 0.7 0.93 9.7 0.4 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.17881.1_1 - 0.04 14.4 2.6 5 7.9 0.4 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.17881.1_1 - 0.094 13.0 0.2 0.27 11.6 0.2 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.17881.1_1 - 0.12 12.9 0.1 8 7.1 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.17881.1_1 - 0.13 12.4 4.2 2.6 8.2 0.4 2.9 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Seryl_tRNA_N PF02403.20 MSTRG.17881.1_1 - 0.16 12.1 8.6 0.19 11.9 4.8 2.1 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain MIT PF04212.16 MSTRG.17881.1_1 - 0.27 11.2 2.8 1.1 9.2 0.2 2.6 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain DUF4600 PF15372.4 MSTRG.7208.1_3 - 4.9e-45 152.9 6.6 4.9e-45 152.9 6.6 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4600) Spc7 PF08317.9 MSTRG.7208.1_3 - 0.003 16.3 10.2 0.0051 15.6 10.2 1.4 1 0 0 1 1 1 1 Spc7 kinetochore protein IFT57 PF10498.7 MSTRG.7208.1_3 - 0.11 11.3 6.0 0.28 10.0 5.9 1.6 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 SKA1 PF07160.10 MSTRG.7208.1_3 - 0.19 11.4 10.2 0.025 14.3 2.5 2.1 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 Reo_sigmaC PF04582.10 MSTRG.7208.1_3 - 0.2 10.9 0.5 0.42 9.8 0.3 1.5 1 1 0 1 1 1 0 Reovirus sigma C capsid protein ZapB PF06005.10 MSTRG.7208.1_3 - 0.21 11.9 14.7 0.21 11.9 8.5 2.5 2 0 0 2 2 2 0 Cell division protein ZapB KASH_CCD PF14662.4 MSTRG.7208.1_3 - 0.29 10.8 10.8 0.57 9.9 10.8 1.5 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH PspA_IM30 PF04012.10 MSTRG.7208.1_3 - 0.34 10.3 11.2 0.21 11.0 2.9 2.0 2 0 0 2 2 2 0 PspA/IM30 family Mnd1 PF03962.13 MSTRG.7208.1_3 - 0.36 10.5 12.0 1.1 9.0 1.9 2.2 1 1 1 2 2 2 0 Mnd1 family PRKG1_interact PF15898.3 MSTRG.7208.1_3 - 0.38 11.6 16.8 0.58 11.0 2.7 3.1 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain ADIP PF11559.6 MSTRG.7208.1_3 - 0.41 10.6 12.8 2.3 8.2 7.5 2.6 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Fez1 PF06818.13 MSTRG.7208.1_3 - 0.57 10.5 14.2 3 8.1 12.8 2.0 1 1 1 2 2 2 0 Fez1 DUF1664 PF07889.10 MSTRG.7208.1_3 - 0.64 9.9 5.9 0.81 9.6 1.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF4201 PF13870.4 MSTRG.7208.1_3 - 1.6 8.2 11.8 4 6.9 3.7 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Helo_like_N PF17111.3 MSTRG.7208.1_3 - 3.1 7.0 7.6 5 6.3 2.1 2.4 1 1 2 3 3 3 0 Fungal N-terminal domain of STAND proteins TPR_MLP1_2 PF07926.10 MSTRG.7208.1_3 - 3.8 7.5 13.3 21 5.0 2.2 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein IncA PF04156.12 MSTRG.7208.1_3 - 6.8 6.3 18.3 9.4 5.8 7.2 2.4 1 1 1 2 2 2 0 IncA protein DUF745 PF05335.11 MSTRG.7208.1_3 - 6.8 6.3 7.5 0.47 10.0 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Syntaxin-6_N PF09177.9 MSTRG.7208.1_3 - 7.7 7.0 8.2 3.7e+02 1.6 8.1 2.4 1 1 0 1 1 1 0 Syntaxin 6, N-terminal HAP1_N PF04849.11 MSTRG.7208.1_3 - 9.2 5.2 17.3 1.8 7.5 8.8 2.2 1 1 0 2 2 2 0 HAP1 N-terminal conserved region Ras PF00071.20 MSTRG.24221.2_3 - 6.5e-56 188.3 0.1 9.3e-56 187.8 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.24221.2_3 - 7.8e-36 122.8 0.1 1.3e-35 122.1 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.24221.2_3 - 3.5e-13 49.2 0.0 5.6e-13 48.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 MSTRG.24221.2_3 - 0.00037 19.8 0.0 0.00051 19.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 MSTRG.24221.2_3 - 0.0056 16.1 0.0 0.0088 15.5 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 MSTRG.24221.2_3 - 0.0084 16.1 0.0 0.014 15.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 MSTRG.24221.2_3 - 0.099 12.4 0.2 1.5 8.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 eIF2_C PF09173.9 MSTRG.2267.1_1 - 1.2e-37 127.9 0.5 1.2e-37 127.9 0.5 1.7 2 0 0 2 2 2 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.25 MSTRG.2267.1_1 - 3.9e-18 65.6 0.0 6.4e-18 64.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.23 MSTRG.2267.1_1 - 1.3e-12 47.8 0.3 3.3e-12 46.5 0.3 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1_Xtn PF16897.3 MSTRG.2267.1_1 - 0.015 15.2 0.1 0.031 14.2 0.1 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain DUF258 PF03193.14 MSTRG.2267.1_1 - 0.015 15.0 0.1 0.025 14.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 RPEL PF02755.13 MSTRG.458.3_1 - 1.7e-22 78.2 8.2 6.7e-07 28.7 0.1 3.6 3 0 0 3 3 3 3 RPEL repeat SAP PF02037.25 MSTRG.458.3_1 - 9.5e-12 44.3 0.4 1.8e-11 43.4 0.4 1.5 1 0 0 1 1 1 1 SAP domain PKcGMP_CC PF16808.3 MSTRG.458.3_1 - 0.069 12.9 6.5 0.17 11.6 6.5 1.7 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Fibrinogen_C PF00147.16 MSTRG.12679.3_1 - 1e-54 185.6 2.0 1.4e-54 185.1 2.0 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain USP8_interact PF08941.8 MSTRG.12679.3_1 - 0.028 14.1 2.1 0.15 11.8 0.1 2.2 2 0 0 2 2 2 0 USP8 interacting DUF16 PF01519.14 MSTRG.12679.3_1 - 0.34 11.3 12.0 4.6 7.7 3.5 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF1664 PF07889.10 MSTRG.12679.3_1 - 0.47 10.3 8.3 0.16 11.9 2.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Atg14 PF10186.7 MSTRG.12679.3_1 - 0.52 9.2 5.4 0.96 8.3 5.4 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Cauli_AT PF03233.11 MSTRG.12679.3_1 - 0.95 9.2 5.1 1.6 8.5 0.6 2.7 3 0 0 3 3 3 0 Aphid transmission protein Fib_alpha PF08702.8 MSTRG.12679.3_1 - 1.1 9.3 8.9 5.6 7.0 8.9 2.1 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Exonuc_VII_L PF02601.13 MSTRG.12679.3_1 - 1.3 8.4 4.6 4.2 6.7 4.6 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit E2R135 PF11570.6 MSTRG.12679.3_1 - 3.7 7.7 5.8 4.5 7.4 0.1 2.7 3 0 0 3 3 3 0 Coiled-coil receptor-binding R-domain of colicin E2 Spc7 PF08317.9 MSTRG.12679.3_1 - 3.7 6.2 12.1 16 4.2 4.0 1.8 1 1 1 2 2 2 0 Spc7 kinetochore protein SlyX PF04102.10 MSTRG.12679.3_1 - 5.2 7.6 10.3 0.28 11.7 1.9 2.6 2 1 1 3 3 3 0 SlyX DUF2203 PF09969.7 MSTRG.12679.3_1 - 7.6 7.1 5.9 4.2 8.0 1.5 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Aldo_ket_red PF00248.19 MSTRG.21039.1_3 - 0.0001 21.4 0.0 0.00014 21.0 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family HAUS5 PF14817.4 MSTRG.8443.2_1 - 2e-201 671.0 41.0 2.4e-201 670.8 41.0 1.0 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 5 Baculo_LEF-10 PF07206.9 MSTRG.8443.2_1 - 0.024 14.7 0.0 0.07 13.2 0.0 1.8 1 0 0 1 1 1 0 Baculovirus late expression factor 10 (LEF-10) COG2 PF06148.9 MSTRG.8443.2_1 - 0.052 13.5 13.8 0.73 9.8 1.0 3.9 3 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Atg14 PF10186.7 MSTRG.8443.2_1 - 0.76 8.7 24.5 0.98 8.3 6.7 2.6 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4085 PF13315.4 MSTRG.8443.2_1 - 0.79 9.2 6.0 0.13 11.7 0.2 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4085) Cnn_1N PF07989.9 MSTRG.8443.2_1 - 1.1 9.3 19.5 1.2 9.2 1.8 4.1 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 DUF4094 PF13334.4 MSTRG.8443.2_1 - 1.6 9.0 12.8 7.1 7.0 0.5 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4094) PTH2 PF01981.14 MSTRG.19950.1_2 - 3.1e-36 124.0 0.8 4.4e-36 123.5 0.8 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 UBA PF00627.29 MSTRG.19950.1_2 - 0.0054 16.5 0.1 0.01 15.6 0.1 1.4 1 0 0 1 1 1 1 UBA/TS-N domain Ribosomal_L1 PF00687.19 MSTRG.3492.7_3 - 2.9e-47 160.9 0.4 2.9e-47 160.9 0.4 1.6 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family Presenilin PF01080.15 MSTRG.3492.7_3 - 2.1 6.9 3.9 2.9 6.4 3.9 1.1 1 0 0 1 1 1 0 Presenilin zf-H2C2_2 PF13465.4 MSTRG.21526.1_3 - 8.6e-74 240.8 54.3 1.9e-08 34.3 0.2 10.8 10 0 0 10 10 10 10 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.21526.1_3 - 6.5e-40 133.3 69.4 7e-06 26.1 1.1 10.5 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.21526.1_3 - 1.2e-35 118.9 67.9 9.9e-05 22.7 1.1 10.4 10 0 0 10 10 10 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.21526.1_3 - 2.1e-13 49.7 48.1 0.01 15.6 0.4 9.9 9 0 0 9 9 9 6 C2H2-type zinc finger zf-Di19 PF05605.10 MSTRG.21526.1_3 - 3e-13 49.7 39.9 6.7e-06 26.2 2.9 5.2 3 1 3 6 6 6 4 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.5 MSTRG.21526.1_3 - 9e-08 32.1 53.4 0.021 15.1 0.4 9.2 9 0 0 9 9 9 5 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.4 MSTRG.21526.1_3 - 1.8e-07 30.6 48.0 0.045 13.4 0.2 9.3 9 0 0 9 9 9 5 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.6 MSTRG.21526.1_3 - 3.6e-07 30.2 19.4 0.8 10.0 0.0 8.2 9 0 0 9 9 9 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 MSTRG.21526.1_3 - 0.0019 18.4 41.6 1.1 9.5 0.5 8.4 1 1 6 8 8 8 2 C2H2 type zinc-finger (2 copies) Elf1 PF05129.11 MSTRG.21526.1_3 - 0.014 15.2 37.7 0.15 12.0 0.8 6.1 1 1 7 8 8 8 0 Transcription elongation factor Elf1 like C1_1 PF00130.20 MSTRG.21526.1_3 - 0.036 13.8 0.5 0.036 13.8 0.5 6.1 1 1 7 8 8 8 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF2180 PF09947.7 MSTRG.21526.1_3 - 0.075 12.9 14.1 5 7.0 0.3 4.8 1 1 2 5 5 5 0 Uncharacterized protein conserved in archaea (DUF2180) BolA PF01722.16 MSTRG.21526.1_3 - 0.079 13.1 9.2 15 5.9 1.0 4.7 3 1 0 3 3 3 0 BolA-like protein Zf_RING PF16744.3 MSTRG.21526.1_3 - 0.11 12.5 26.5 1.8 8.6 0.2 7.3 1 1 6 8 8 8 0 KIAA1045 RING finger PHD_4 PF16866.3 MSTRG.21526.1_3 - 0.19 11.7 27.6 0.64 10.0 3.8 5.3 1 1 5 7 7 7 0 PHD-finger PTPRCAP PF15713.3 MSTRG.21526.1_3 - 0.46 10.6 3.8 0.35 11.0 2.2 1.6 1 1 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated zinc_ribbon_15 PF17032.3 MSTRG.21526.1_3 - 1.2 9.8 27.4 4.7 7.9 1.2 5.1 1 1 3 5 5 5 0 zinc-ribbon family Sin3a_C PF16879.3 MSTRG.8444.1_3 - 9.7e-80 268.2 4.1 9.7e-80 268.2 4.1 2.0 2 0 0 2 2 2 1 C-terminal domain of Sin3a protein Sin3_corepress PF08295.10 MSTRG.8444.1_3 - 1e-41 140.8 0.1 1e-41 140.8 0.1 2.1 2 0 0 2 2 2 1 Sin3 family co-repressor PAH PF02671.19 MSTRG.8444.1_3 - 1.3e-41 140.3 6.0 9.8e-18 63.9 0.0 4.1 4 0 0 4 4 4 3 Paired amphipathic helix repeat EHN PF06441.10 MSTRG.16492.2_2 - 1e-34 118.9 0.2 1.8e-34 118.1 0.2 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.18 MSTRG.16492.2_2 - 1.1e-18 67.7 0.0 1.9e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 MSTRG.16492.2_2 - 0.035 14.6 0.0 0.07 13.6 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family SET PF00856.26 MSTRG.313.2_1 - 1.8e-16 60.9 0.2 1.8e-16 60.9 0.2 2.5 3 0 0 3 3 3 1 SET domain EZH2_WD-Binding PF11616.6 MSTRG.313.2_1 - 1.8e-13 50.2 0.5 3.4e-13 49.3 0.5 1.5 1 0 0 1 1 1 1 WD repeat binding protein EZH2 zf-LITAF-like PF10601.7 MSTRG.18646.1_2 - 2.5e-25 88.4 16.8 6.6e-25 87.1 16.8 1.8 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain Clat_adaptor_s PF01217.18 MSTRG.26075.1_1 - 2.2e-33 115.0 2.6 3.5e-33 114.4 2.6 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Ceramidse_alk_C PF17048.3 MSTRG.10165.1_2 - 1.8e-12 47.3 0.0 2.7e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal ubiquitin PF00240.21 MSTRG.10410.1_3 - 2.3e-09 36.7 0.0 3.6e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family DUF1614 PF07758.9 MSTRG.10410.1_3 - 0.029 14.2 0.7 0.28 11.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1614) CP2 PF04516.13 MSTRG.578.3_3 - 5.2e-58 195.9 0.0 8.1e-58 195.3 0.0 1.2 1 0 0 1 1 1 1 CP2 transcription factor zf-H2C2_2 PF13465.4 MSTRG.6378.1_3 - 1e-58 193.1 48.1 8.2e-09 35.4 1.1 9.6 9 0 0 9 9 9 8 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.6378.1_3 - 2.2e-34 115.9 54.1 2.9e-05 24.1 1.8 8.9 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.6378.1_3 - 1.1e-28 97.2 53.7 6.7e-05 23.3 1.2 10.1 10 0 0 10 10 10 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.6378.1_3 - 8.3e-16 57.4 34.2 0.015 15.1 0.2 8.8 9 0 0 9 9 9 6 C2H2-type zinc finger zf-met PF12874.5 MSTRG.6378.1_3 - 2.3e-15 56.3 49.2 0.0079 16.4 0.2 9.8 10 0 0 10 10 10 7 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.6378.1_3 - 9.6e-14 51.1 12.8 0.023 14.9 0.0 6.7 7 0 0 7 7 6 4 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 MSTRG.6378.1_3 - 0.00026 21.1 30.1 0.041 14.0 1.6 5.4 2 1 1 4 4 4 4 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.3 MSTRG.6378.1_3 - 0.0013 18.3 0.1 0.0013 18.3 0.1 7.6 8 0 0 8 8 8 1 zinc-finger C2H2-type zf-H2C2_5 PF13909.4 MSTRG.6378.1_3 - 0.0014 18.2 43.2 0.7 9.6 1.4 8.1 8 0 0 8 8 8 4 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.5 MSTRG.6378.1_3 - 0.0084 16.3 34.5 7.4 6.8 0.4 8.0 1 1 6 7 7 7 2 C2H2 type zinc-finger (2 copies) CNRIP1 PF15043.4 MSTRG.6378.1_3 - 0.019 14.4 0.1 1.9 7.9 0.0 2.8 3 0 0 3 3 3 0 CB1 cannabinoid receptor-interacting protein 1 Zn-ribbon_8 PF09723.8 MSTRG.6378.1_3 - 0.11 12.6 21.1 0.42 10.7 0.6 5.7 1 1 6 7 7 7 0 Zinc ribbon domain zf-Sec23_Sec24 PF04810.13 MSTRG.6378.1_3 - 0.17 11.8 24.5 2.2 8.3 0.2 6.6 4 3 3 7 7 7 0 Sec23/Sec24 zinc finger zf-NPL4 PF05020.13 MSTRG.6378.1_3 - 0.3 11.1 4.5 11 6.0 0.1 3.2 2 1 1 3 3 3 0 NPL4 family, putative zinc binding region zf-BED PF02892.13 MSTRG.6378.1_3 - 0.35 10.8 45.9 0.11 12.5 1.5 7.8 1 1 7 8 8 8 0 BED zinc finger zinc_ribbon_15 PF17032.3 MSTRG.6378.1_3 - 0.4 11.3 20.5 4.2 8.1 1.0 4.6 1 1 2 4 4 4 0 zinc-ribbon family GATA PF00320.25 MSTRG.6378.1_3 - 0.6 9.6 0.0 0.6 9.6 0.0 4.0 5 0 0 5 5 4 0 GATA zinc finger DUF3268 PF11672.6 MSTRG.6378.1_3 - 0.81 9.9 18.4 7.2 6.8 0.1 4.2 1 1 4 6 6 6 0 zinc-finger-containing domain BolA PF01722.16 MSTRG.6378.1_3 - 1.3 9.2 5.2 25 5.1 0.0 3.8 4 0 0 4 4 4 0 BolA-like protein Actin PF00022.17 MSTRG.9318.1_1 - 2.2e-45 154.9 0.0 1.1e-22 80.2 0.0 2.2 2 0 0 2 2 2 2 Actin Caldesmon PF02029.13 MSTRG.15261.5_3 - 6.1e-173 576.0 90.3 6.1e-173 576.0 90.3 1.8 2 0 0 2 2 2 1 Caldesmon Ank_2 PF12796.5 MSTRG.15747.1_1 - 0.00016 22.0 0.1 0.00062 20.2 0.1 1.9 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.15747.1_1 - 0.00051 20.2 0.2 0.45 10.9 0.1 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.4 MSTRG.15747.1_1 - 0.003 18.0 0.0 0.083 13.4 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.15747.1_1 - 0.021 15.2 1.2 1 10.0 0.0 2.5 3 0 0 3 3 3 0 Ankyrin repeat Ank PF00023.28 MSTRG.15747.1_1 - 0.04 14.3 2.9 0.82 10.1 0.0 2.7 3 0 0 3 3 3 0 Ankyrin repeat Dynamin_M PF01031.18 MSTRG.12951.2_1 - 7.8e-109 363.2 2.1 1.1e-108 362.6 2.1 1.2 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.21 MSTRG.12951.2_1 - 7.2e-55 185.5 0.0 1.2e-54 184.7 0.0 1.4 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.21 MSTRG.12951.2_1 - 0.00035 20.5 0.1 0.0012 18.8 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase Carb_anhydrase PF00194.19 MSTRG.15505.1_1 - 7.9e-73 245.0 0.0 9.8e-73 244.7 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase HTH_Tnp_4 PF13613.4 MSTRG.1451.1_1 - 6.9e-16 57.7 0.6 1.3e-15 56.8 0.6 1.5 1 0 0 1 1 1 1 Helix-turn-helix of DDE superfamily endonuclease DDE_Tnp_4 PF13359.4 MSTRG.1451.1_1 - 8.4e-16 57.9 0.0 2.1e-15 56.6 0.0 1.7 1 0 0 1 1 1 1 DDE superfamily endonuclease THAP PF05485.10 MSTRG.1451.1_1 - 7e-13 49.2 0.0 1.4e-12 48.2 0.0 1.6 1 0 0 1 1 1 1 THAP domain SKA1 PF07160.10 MSTRG.1451.1_2 - 1.7e-06 28.0 8.0 5.3e-05 23.0 0.1 2.2 2 0 0 2 2 2 2 Spindle and kinetochore-associated protein 1 AIM3 PF17096.3 MSTRG.1451.1_2 - 0.18 12.6 1.3 0.4 11.5 1.3 1.5 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 3 FRG1 PF06229.10 MSTRG.27508.1_2 - 3.1e-81 271.5 0.1 3.1e-81 271.5 0.1 1.6 2 0 0 2 2 2 1 FRG1-like domain Fascin PF06268.11 MSTRG.27508.1_2 - 1.9e-05 24.7 0.0 0.0022 18.1 0.0 2.1 1 1 2 3 3 3 2 Fascin domain DUF569 PF04601.11 MSTRG.27508.1_2 - 0.0067 16.0 0.0 0.046 13.3 0.0 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF569) DUF1754 PF08555.8 MSTRG.27508.1_2 - 2.1 9.1 11.9 5.6 7.7 11.9 1.7 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) IRF-3 PF10401.7 MSTRG.20385.1_3 - 3.2e-56 189.8 0.3 7.5e-56 188.6 0.0 1.7 2 0 0 2 2 2 1 Interferon-regulatory factor 3 IRF PF00605.15 MSTRG.20385.1_3 - 8.3e-39 132.0 2.3 8.3e-39 132.0 2.3 2.0 3 0 0 3 3 3 1 Interferon regulatory factor transcription factor Tropomyosin PF00261.18 MSTRG.6134.1_2 - 7.5e-99 329.8 84.2 1.2e-96 322.6 61.2 2.0 1 1 1 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.5 MSTRG.6134.1_2 - 1.3e-37 128.9 73.9 3.4e-33 114.6 41.6 3.2 1 1 0 2 2 2 2 Tropomyosin like Laminin_II PF06009.10 MSTRG.6134.1_2 - 4.8e-06 26.5 35.0 1.3e-05 25.1 7.2 3.5 1 1 3 4 4 4 2 Laminin Domain II CLZ PF16526.3 MSTRG.6134.1_2 - 0.00014 22.0 47.7 0.0025 18.0 11.3 4.8 2 2 2 5 5 5 3 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TMF_DNA_bd PF12329.6 MSTRG.6134.1_2 - 0.00035 20.4 18.7 0.0015 18.3 9.6 6.2 2 2 4 6 6 6 2 TATA element modulatory factor 1 DNA binding XhlA PF10779.7 MSTRG.6134.1_2 - 0.0056 16.7 2.9 0.0056 16.7 2.9 6.1 2 2 5 7 7 7 2 Haemolysin XhlA ERM PF00769.17 MSTRG.6134.1_2 - 0.011 15.4 69.4 0.19 11.4 23.9 2.7 1 1 1 2 2 2 0 Ezrin/radixin/moesin family IncA PF04156.12 MSTRG.6134.1_2 - 0.012 15.3 58.1 0.021 14.5 24.0 3.0 1 1 2 3 3 3 0 IncA protein Golgin_A5 PF09787.7 MSTRG.6134.1_2 - 0.015 14.6 52.5 0.14 11.5 19.3 2.3 1 1 1 2 2 2 0 Golgin subfamily A member 5 SlyX PF04102.10 MSTRG.6134.1_2 - 0.045 14.2 0.5 0.045 14.2 0.5 5.1 1 1 4 5 5 5 0 SlyX DUF745 PF05335.11 MSTRG.6134.1_2 - 0.051 13.2 47.2 0.3 10.7 9.9 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF745) SNARE PF05739.17 MSTRG.6134.1_2 - 0.085 12.7 4.9 2.1 8.3 0.1 4.0 3 0 0 3 3 3 0 SNARE domain Reo_sigmaC PF04582.10 MSTRG.6134.1_2 - 0.14 11.4 6.6 0.18 11.0 0.6 2.1 2 0 0 2 2 2 0 Reovirus sigma C capsid protein ATG16 PF08614.9 MSTRG.6134.1_2 - 0.16 12.0 63.5 0.16 12.0 20.6 3.3 1 1 2 3 3 2 0 Autophagy protein 16 (ATG16) Lebercilin PF15619.4 MSTRG.6134.1_2 - 0.19 11.2 60.3 0.33 10.5 28.4 2.8 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease HrpB7 PF09486.8 MSTRG.6134.1_2 - 0.33 11.2 53.0 0.12 12.6 15.5 4.5 1 1 2 4 4 4 0 Bacterial type III secretion protein (HrpB7) AAA_13 PF13166.4 MSTRG.6134.1_2 - 0.39 9.2 48.6 0.89 8.0 13.8 2.2 1 1 1 2 2 2 0 AAA domain DUF1664 PF07889.10 MSTRG.6134.1_2 - 0.44 10.4 26.2 0.26 11.1 3.5 3.8 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) DUF16 PF01519.14 MSTRG.6134.1_2 - 0.78 10.1 36.4 0.43 10.9 0.4 4.2 1 1 3 4 4 4 0 Protein of unknown function DUF16 CENP-F_leu_zip PF10473.7 MSTRG.6134.1_2 - 0.8 9.6 66.1 0.015 15.2 30.2 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1794 PF08768.9 MSTRG.6134.1_2 - 1.2 9.0 3.5 12 5.8 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1794) Laminin_I PF06008.12 MSTRG.6134.1_2 - 2.2 7.8 56.2 0.98 8.9 28.1 3.3 1 1 2 3 3 3 0 Laminin Domain I TTKRSYEDQ PF10212.7 MSTRG.6134.1_2 - 2.8 6.7 36.5 0.3 9.9 12.6 2.1 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein APG6 PF04111.10 MSTRG.6134.1_2 - 3.6 6.8 65.3 0.61 9.3 25.1 3.1 1 1 2 3 3 3 0 Autophagy protein Apg6 UPF0693 PF16088.3 MSTRG.6134.1_2 - 3.9 7.6 17.7 0.31 11.2 0.5 4.1 2 2 1 3 3 3 0 UPF0693 family Exonuc_VII_L PF02601.13 MSTRG.6134.1_2 - 6 6.2 35.4 16 4.8 13.0 2.2 1 1 1 2 2 2 0 Exonuclease VII, large subunit Flagellin_C PF00700.19 MSTRG.6134.1_2 - 6.3 7.1 11.3 0.66 10.3 1.1 3.5 2 2 2 4 4 4 0 Bacterial flagellin C-terminal helical region DUF2721 PF11026.6 MSTRG.6134.1_2 - 6.4 6.5 9.6 11 5.8 0.3 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF2721) Baculo_PEP_C PF04513.10 MSTRG.6134.1_2 - 8.3 6.3 12.0 7.2 6.5 2.3 3.3 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.8 MSTRG.6134.1_2 - 8.8 6.4 29.0 0.28 11.2 6.9 3.1 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family AstE_AspA PF04952.12 MSTRG.22842.1_1 - 8.9e-61 205.4 0.0 1.1e-60 205.1 0.0 1.1 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family Aminotran_5 PF00266.17 MSTRG.14709.1_2 - 5.2e-31 107.8 0.0 7e-31 107.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V DUF4074 PF13293.4 MSTRG.3430.1_3 - 9e-34 115.5 3.6 3.3e-33 113.7 3.6 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4074) Homeobox PF00046.27 MSTRG.3430.1_3 - 3.8e-21 74.5 4.9 7.3e-21 73.6 4.9 1.5 1 0 0 1 1 1 1 Homeobox domain DUF498 PF04430.12 MSTRG.620.1_1 - 4.5e-16 58.7 0.0 6.9e-16 58.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Nebulin PF00880.16 MSTRG.1479.14_1 - 0 1699.0 573.4 2.5e-10 40.0 2.0 139.0 144 0 0 144 144 144 111 Nebulin repeat Peptidase_M24 PF00557.22 MSTRG.1479.14_1 - 2.9e-14 53.1 3.3 0.28 10.7 0.0 9.2 9 0 0 9 9 9 5 Metallopeptidase family M24 SH3_1 PF00018.26 MSTRG.1479.14_1 - 3.2e-12 45.7 0.0 1.5e-11 43.6 0.0 2.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.1479.14_1 - 3.4e-12 45.9 0.0 7.3e-12 44.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.1479.14_1 - 1e-05 25.0 0.0 7.8e-05 22.2 0.0 2.6 2 0 0 2 2 2 1 Variant SH3 domain Toprim_2 PF13155.4 MSTRG.1479.14_1 - 0.12 12.7 4.9 67 3.9 0.0 5.6 5 0 0 5 5 5 0 Toprim-like SSXT PF05030.10 MSTRG.5429.1_3 - 1.6e-27 94.8 0.2 2.4e-27 94.2 0.2 1.2 1 0 0 1 1 1 1 SSXT protein (N-terminal region) ADP_PFK_GK PF04587.13 MSTRG.5429.1_3 - 0.095 11.1 0.0 0.12 10.8 0.0 1.1 1 0 0 1 1 1 0 ADP-specific Phosphofructokinase/Glucokinase conserved region Sec7 PF01369.18 MSTRG.550.1_1 - 3.9e-67 225.4 0.5 1.4e-66 223.6 0.5 2.0 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.5 MSTRG.550.1_1 - 2.9e-50 170.2 2.8 2.9e-50 170.2 2.8 3.5 5 0 0 5 5 5 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.3 MSTRG.550.1_1 - 1.5e-36 125.6 1.5 1.5e-36 125.6 1.5 3.0 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 DUF1981 PF09324.8 MSTRG.550.1_1 - 8.5e-36 121.6 0.3 8.5e-36 121.6 0.3 5.5 7 0 0 7 7 7 1 Domain of unknown function (DUF1981) Ras PF00071.20 MSTRG.27039.1_1 - 9.2e-09 35.0 0.0 1.4e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.27039.1_1 - 2.2e-07 31.0 0.0 3.5e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.21 MSTRG.27039.1_1 - 0.0072 16.3 0.0 0.017 15.0 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase CbiA PF01656.21 MSTRG.27039.1_1 - 0.016 15.1 0.6 0.033 14.1 0.6 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF258 PF03193.14 MSTRG.27039.1_1 - 0.043 13.6 0.0 0.098 12.4 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_29 PF13555.4 MSTRG.27039.1_1 - 0.086 12.4 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain NTPase_1 PF03266.13 MSTRG.27039.1_1 - 0.1 12.4 0.0 1.8 8.3 0.0 2.1 2 0 0 2 2 2 0 NTPase ABC_tran PF00005.25 MSTRG.27039.1_1 - 0.11 12.8 0.0 0.19 12.1 0.0 1.2 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.4 MSTRG.27039.1_1 - 0.12 12.6 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.10 MSTRG.27039.1_1 - 0.13 12.1 0.6 0.23 11.2 0.2 1.7 2 1 0 2 2 2 0 NACHT domain AAA_5 PF07728.12 MSTRG.27039.1_1 - 0.15 11.9 0.1 0.27 11.1 0.1 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.4 MSTRG.27039.1_1 - 0.15 12.4 0.1 0.77 10.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain ParA PF10609.7 MSTRG.27039.1_1 - 0.16 11.3 0.2 0.26 10.6 0.2 1.2 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase RRM_1 PF00076.20 MSTRG.26078.4_2 - 3.2e-34 116.4 0.3 6.6e-18 64.2 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.26078.4_2 - 9.6e-12 44.7 0.4 6.3e-05 22.9 0.0 2.7 2 2 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.4 MSTRG.26078.4_2 - 4.4e-05 23.2 0.1 0.18 11.7 0.1 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif CSD PF00313.20 MSTRG.26078.4_2 - 0.004 16.8 0.6 0.18 11.6 0.2 2.3 2 0 0 2 2 2 1 'Cold-shock' DNA-binding domain NID PF07292.11 MSTRG.26078.4_2 - 0.017 15.6 0.8 5.5 7.6 0.0 2.3 2 0 0 2 2 2 0 Nmi/IFP 35 domain (NID) DUF4651 PF15513.4 MSTRG.26078.4_2 - 0.066 12.9 0.0 11 5.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4651) RRM_3 PF08777.9 MSTRG.26078.4_2 - 0.068 13.1 0.2 11 5.9 0.1 2.6 2 1 0 2 2 2 0 RNA binding motif PPR_1 PF12854.5 MSTRG.26078.4_2 - 1.8 8.2 4.0 9.5 5.9 0.1 2.4 2 0 0 2 2 2 0 PPR repeat Mago-bind PF09282.8 MSTRG.4478.3_1 - 7.6e-14 51.1 3.0 1.2e-13 50.5 3.0 1.3 1 0 0 1 1 1 1 Mago binding U-box PF04564.13 MSTRG.17523.1_2 - 4.6e-23 81.1 0.1 6.2e-23 80.6 0.1 1.2 1 0 0 1 1 1 1 U-box domain zf-NOSIP PF15906.3 MSTRG.17523.1_2 - 0.00014 21.8 0.0 0.00018 21.4 0.0 1.2 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.6 MSTRG.17523.1_2 - 0.00016 21.3 0.0 0.00027 20.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Dynamin_M PF01031.18 MSTRG.1630.1_2 - 2.5e-88 295.9 0.1 2e-43 148.5 0.0 2.5 2 0 0 2 2 2 2 Dynamin central region Dynamin_N PF00350.21 MSTRG.1630.1_2 - 9.2e-56 188.4 0.4 4.2e-55 186.2 0.0 2.1 2 0 0 2 2 2 1 Dynamin family GED PF02212.16 MSTRG.1630.1_2 - 4.3e-33 113.2 2.1 1.1e-32 111.9 2.1 1.7 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.21 MSTRG.1630.1_2 - 4.8e-06 26.5 0.2 3.3e-05 23.8 0.2 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.4 MSTRG.1630.1_2 - 0.015 15.5 0.1 0.8 9.9 0.0 3.0 3 0 0 3 3 3 0 AAA ATPase domain NAC PF01849.16 MSTRG.17131.1_3 - 8.5e-26 89.6 0.3 1.7e-25 88.7 0.3 1.5 1 0 0 1 1 1 1 NAC domain Dimer_Tnp_hAT PF05699.12 MSTRG.12128.1_1 - 2.9e-14 52.5 0.0 5.3e-14 51.6 0.0 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4413 PF14372.4 MSTRG.12128.1_1 - 0.014 15.6 0.1 0.046 13.9 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4413) zf-BED PF02892.13 MSTRG.12128.1_2 - 7.7e-07 28.9 0.3 2.3e-06 27.4 0.3 1.9 1 0 0 1 1 1 1 BED zinc finger PS_pyruv_trans PF04230.11 MSTRG.19386.1_2 - 0.16 11.7 0.1 0.19 11.5 0.1 1.1 1 0 0 1 1 1 0 Polysaccharide pyruvyl transferase Erf4 PF10256.7 MSTRG.13755.2_3 - 1e-30 106.0 0.0 1.6e-30 105.5 0.0 1.3 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family FoP_duplication PF13865.4 MSTRG.3656.2_1 - 1.4e-18 67.1 16.0 1.9e-12 47.4 1.8 3.8 3 1 1 4 4 4 2 C-terminal duplication domain of Friend of PRMT1 PI3_PI4_kinase PF00454.25 MSTRG.3656.2_3 - 5.9e-32 111.3 0.0 2.5e-21 76.5 0.0 2.2 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.18 MSTRG.3656.2_3 - 0.0042 16.4 0.1 0.01 15.1 0.1 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Cation_ATPase_C PF00689.19 MSTRG.6424.1_1 - 8e-44 149.4 4.1 1.1e-43 148.9 4.1 1.2 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.24 MSTRG.6424.1_1 - 1.4e-15 58.1 0.0 2.3e-15 57.3 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.10 MSTRG.6424.1_1 - 3.1e-06 27.0 1.2 3.8e-06 26.7 0.5 1.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 MSTRG.6424.1_1 - 5.2e-05 23.6 0.0 0.00021 21.6 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase FUN14 PF04930.13 MSTRG.12440.3_1 - 9.8e-27 93.1 2.0 1.7e-26 92.3 2.0 1.4 1 0 0 1 1 1 1 FUN14 family Clusterin PF01093.15 MSTRG.7848.7_1 - 2.8e-59 201.1 0.0 3.5e-59 200.8 0.0 1.1 1 0 0 1 1 1 1 Clusterin PHD_4 PF16866.3 MSTRG.7848.7_1 - 0.017 15.1 0.3 0.043 13.8 0.3 1.6 1 0 0 1 1 1 0 PHD-finger DUF3565 PF12088.6 MSTRG.7848.7_3 - 0.025 14.4 1.2 0.051 13.4 1.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3565) zf-B_box PF00643.22 MSTRG.15045.2_1 - 0.00013 22.0 9.7 0.00013 22.0 9.7 2.3 2 0 0 2 2 2 1 B-box zinc finger Ima1_N PF09779.7 MSTRG.15045.2_1 - 0.018 15.8 0.9 0.018 15.8 0.9 1.8 1 1 1 2 2 2 0 Ima1 N-terminal domain ArAE_2_N PF10337.7 MSTRG.15045.2_1 - 0.061 12.2 0.8 0.079 11.9 0.8 1.1 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal HMG_box PF00505.17 MSTRG.886.1_2 - 3.4e-40 136.2 11.0 1.4e-24 86.1 0.4 2.5 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.8 MSTRG.886.1_2 - 3.9e-40 136.2 12.9 7.4e-26 90.4 6.9 2.5 2 0 0 2 2 2 2 HMG-box domain CENP-B_dimeris PF09026.8 MSTRG.886.1_2 - 0.00016 21.9 5.4 0.00028 21.1 5.4 1.4 1 0 0 1 1 1 1 Centromere protein B dimerisation domain RNA_pol_3_Rpc31 PF11705.6 MSTRG.886.1_2 - 0.0003 20.9 14.5 0.00052 20.2 14.5 1.4 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 HMG_box_5 PF14887.4 MSTRG.886.1_2 - 0.026 14.4 10.4 0.25 11.2 3.5 2.4 2 0 0 2 2 2 0 HMG (high mobility group) box 5 NOA36 PF06524.10 MSTRG.886.1_2 - 0.21 10.8 16.0 0.44 9.7 16.0 1.5 1 0 0 1 1 1 0 NOA36 protein Ribosomal_60s PF00428.17 MSTRG.886.1_2 - 0.52 10.8 20.9 1.3 9.5 20.9 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Nop14 PF04147.10 MSTRG.886.1_2 - 3.2 5.7 15.2 4.3 5.3 15.2 1.2 1 0 0 1 1 1 0 Nop14-like family PDEase_I PF00233.17 MSTRG.10703.2_2 - 3.6e-93 311.5 3.6 3.6e-93 311.5 3.6 1.6 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase CortBP2 PF09727.7 MSTRG.16007.3_1 - 1.6 8.4 51.8 0.097 12.4 17.5 3.1 1 1 2 3 3 3 0 Cortactin-binding protein-2 CCDC144C PF14915.4 MSTRG.16007.3_1 - 1.9 7.4 53.7 1.6 7.6 16.8 3.0 2 1 1 3 3 3 0 CCDC144C protein coiled-coil region FliD_N PF02465.16 MSTRG.16007.3_1 - 9.6 6.9 15.2 0.042 14.4 1.6 3.1 2 1 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus Pkinase PF00069.23 MSTRG.9204.2_1 - 7.1e-14 51.7 0.0 1e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.9204.2_1 - 0.0015 17.8 0.0 0.0023 17.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Nefa_Nip30_N PF10187.7 MSTRG.11647.3_1 - 0.00059 20.0 2.5 0.00059 20.0 2.5 1.5 2 0 0 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 Nefa_Nip30_N PF10187.7 MSTRG.11647.3_2 - 8.2e-23 80.6 12.9 1.7e-22 79.6 12.9 1.5 1 0 0 1 1 1 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 TSP_1 PF00090.17 MSTRG.356.1_1 - 0.00067 19.7 4.0 0.00067 19.7 4.0 2.4 2 0 0 2 2 2 1 Thrombospondin type 1 domain Trypsin PF00089.24 MSTRG.10434.1_3 - 8e-67 225.1 0.0 8e-67 225.1 0.0 1.9 2 0 0 2 2 2 1 Trypsin Gla PF00594.18 MSTRG.10434.1_3 - 3.8e-16 58.9 8.2 3.8e-16 58.9 8.2 1.6 2 0 0 2 2 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FXa_inhibition PF14670.4 MSTRG.10434.1_3 - 1.4e-09 38.0 27.9 2.8e-09 37.0 11.7 2.7 2 0 0 2 2 2 2 Coagulation Factor Xa inhibitory site Trypsin_2 PF13365.4 MSTRG.10434.1_3 - 1.8e-07 32.0 0.0 3.3e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 MSTRG.10434.1_3 - 5.6e-07 29.8 0.0 2.7e-06 27.6 0.0 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) EGF PF00008.25 MSTRG.10434.1_3 - 5.1e-05 23.4 6.5 5.1e-05 23.4 6.5 2.9 3 0 0 3 3 2 2 EGF-like domain hEGF PF12661.5 MSTRG.10434.1_3 - 0.00044 20.7 4.8 0.00044 20.7 4.8 4.3 4 1 0 4 4 3 1 Human growth factor-like EGF EGF_3 PF12947.5 MSTRG.10434.1_3 - 0.029 14.5 23.5 0.045 13.8 7.6 3.0 2 0 0 2 2 2 0 EGF domain Toxin_29 PF08116.9 MSTRG.10434.1_3 - 0.033 14.1 2.4 0.12 12.3 2.4 2.0 1 0 0 1 1 1 0 PhTx neurotoxin family cEGF PF12662.5 MSTRG.10434.1_3 - 1.9 8.4 24.3 0.12 12.2 1.2 3.1 3 1 0 3 3 3 0 Complement Clr-like EGF-like EGF_2 PF07974.11 MSTRG.10434.1_3 - 7.4 6.9 30.9 0.037 14.3 10.1 3.2 3 0 0 3 3 3 0 EGF-like domain HMG_box PF00505.17 MSTRG.8200.1_3 - 8.4e-15 54.8 0.4 1.4e-14 54.1 0.4 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 MSTRG.8200.1_3 - 8.7e-10 38.9 0.5 1.3e-09 38.3 0.5 1.3 1 0 0 1 1 1 1 HMG-box domain LSM14 PF12701.5 MSTRG.26164.3_2 - 6.8e-30 102.8 0.0 1.1e-29 102.2 0.0 1.3 1 0 0 1 1 1 1 Scd6-like Sm domain SM-ATX PF14438.4 MSTRG.26164.3_2 - 9.2e-08 32.0 0.0 1.8e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Ataxin 2 SM domain RRM_5 PF13893.4 MSTRG.19847.2_1 - 4.1e-53 178.2 2.9 9.7e-39 131.7 0.0 3.9 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.20 MSTRG.19847.2_1 - 1.3e-28 98.5 2.6 2.1e-08 33.7 0.1 4.7 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 MSTRG.19847.2_1 - 2.7e-06 27.0 0.2 0.14 11.9 0.0 4.0 4 0 0 4 4 4 2 Occluded RNA-recognition motif UPF0492 PF15744.3 MSTRG.22736.1_1 - 0.19 10.7 2.2 0.24 10.4 2.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein family UPF0492 Na_sulph_symp PF00939.17 MSTRG.28802.1_1 - 1.3e-23 83.7 0.9 1.5e-23 83.5 0.9 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.14 MSTRG.28802.1_1 - 3.9e-09 36.0 0.6 4.3e-09 35.9 0.6 1.0 1 0 0 1 1 1 1 Citrate transporter THP2 PF09432.8 MSTRG.16021.1_3 - 0.012 15.5 0.0 0.012 15.5 0.0 1.1 1 0 0 1 1 1 0 Tho complex subunit THP2 Sema PF01403.17 MSTRG.5397.2_2 - 5.4e-37 127.4 0.0 1e-36 126.5 0.0 1.4 1 0 0 1 1 1 1 Sema domain PSI PF01437.23 MSTRG.5397.2_2 - 0.00012 22.5 3.8 0.00012 22.5 3.8 2.4 2 0 0 2 2 2 1 Plexin repeat GAS2 PF02187.15 MSTRG.25051.1_3 - 2.7e-28 97.7 0.1 4.2e-28 97.1 0.1 1.3 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain CH PF00307.29 MSTRG.25051.1_3 - 0.00015 21.8 0.0 0.00024 21.1 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain Capsid-VNN PF11729.6 MSTRG.25877.4_3 - 0.077 11.9 0.2 0.11 11.3 0.2 1.1 1 0 0 1 1 1 0 nodavirus capsid protein MSSP PF03940.11 MSTRG.19602.1_1 - 0.19 11.2 4.7 0.069 12.6 0.8 2.3 2 0 0 2 2 2 0 Male specific sperm protein DSPc PF00782.18 MSTRG.19602.1_3 - 6e-13 48.6 0.0 9.2e-13 48.0 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 MSTRG.19602.1_3 - 0.08 12.4 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.4 MSTRG.19602.1_3 - 0.19 11.5 0.0 0.29 10.9 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family zf-H2C2_2 PF13465.4 MSTRG.1386.1_2 - 3.7e-25 87.1 27.5 7.4e-09 35.5 1.1 6.0 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.1386.1_2 - 2.1e-13 49.8 43.0 8.2e-05 22.7 0.7 6.0 6 1 1 7 7 7 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.1386.1_2 - 5.1e-11 42.3 32.2 0.0031 18.1 0.3 6.1 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.1386.1_2 - 3.7e-07 30.2 12.5 0.11 12.7 0.0 5.3 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 MSTRG.1386.1_2 - 4.6e-05 23.0 26.9 0.0037 16.9 0.3 5.0 5 0 0 5 5 5 3 zinc-finger C2H2-type zf-BED PF02892.13 MSTRG.1386.1_2 - 0.0004 20.2 26.5 0.02 14.8 2.3 5.0 3 1 1 4 4 4 3 BED zinc finger zf-met PF12874.5 MSTRG.1386.1_2 - 0.00086 19.5 22.7 0.008 16.4 0.4 5.8 5 0 0 5 5 5 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.5 MSTRG.1386.1_2 - 0.24 11.6 26.6 1.1 9.6 0.2 5.7 3 1 3 6 6 6 0 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.4 MSTRG.1386.1_2 - 4.5 7.2 27.9 0.81 9.6 4.2 5.3 5 0 0 5 5 5 0 C2H2-type zinc finger JmjC PF02373.20 MSTRG.27948.2_2 - 5.3e-43 146.0 0.1 1.3e-42 144.7 0.1 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.4 MSTRG.27948.2_2 - 3.6e-14 52.7 0.0 1.3e-13 51.0 0.0 2.0 1 0 0 1 1 1 1 PHD-zinc-finger like domain PHD_2 PF13831.4 MSTRG.27948.2_2 - 1.1e-13 50.3 6.6 4.1e-13 48.5 6.6 2.1 1 0 0 1 1 1 1 PHD-finger JmjN PF02375.15 MSTRG.27948.2_2 - 3.5e-13 49.1 0.0 9.8e-13 47.7 0.0 1.8 1 0 0 1 1 1 1 jmjN domain PHD PF00628.27 MSTRG.27948.2_2 - 1.1e-05 25.1 4.1 5.8e-05 22.8 4.1 2.3 1 0 0 1 1 1 1 PHD-finger DNA_pol_phi PF04931.11 MSTRG.27948.2_2 - 0.84 7.6 5.7 1.3 6.9 5.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi PHD_4 PF16866.3 MSTRG.27948.2_2 - 4.6 7.3 11.8 2.6 8.1 7.3 3.0 2 0 0 2 2 2 0 PHD-finger WHH PF14414.4 MSTRG.15338.1_2 - 0.091 12.5 0.5 14 5.5 0.1 2.5 2 0 0 2 2 2 0 A nuclease of the HNH/ENDO VII superfamily with conserved WHH Mito_carr PF00153.25 MSTRG.12878.4_3 - 2.9e-72 238.5 0.4 8.1e-27 92.9 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein CNH PF00780.20 MSTRG.25896.3_1 - 2.3e-27 96.2 0.0 1.1e-26 94.0 0.0 1.9 1 1 0 1 1 1 1 CNH domain CNH PF00780.20 MSTRG.25896.3_3 - 1.7e-12 47.4 0.0 2.7e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 CNH domain Tweety PF04906.11 MSTRG.6882.1_3 - 1.1e-128 429.3 9.8 1.1e-89 300.8 1.7 2.7 2 1 0 2 2 2 2 Tweety DUF3169 PF11368.6 MSTRG.6882.1_3 - 0.017 14.5 0.0 0.017 14.5 0.0 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3169) ETRAMP PF09716.8 MSTRG.6882.1_3 - 0.42 10.6 0.0 0.42 10.6 0.0 2.7 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) SUR7 PF06687.10 MSTRG.6882.1_3 - 1.3 8.5 16.1 0.42 10.1 4.3 3.2 4 0 0 4 4 4 0 SUR7/PalI family Glucan_synthase PF02364.13 MSTRG.20569.1_3 - 0.016 13.3 10.3 0.02 13.0 10.3 1.0 1 0 0 1 1 1 0 1,3-beta-glucan synthase component Membralin PF09746.7 MSTRG.20569.1_3 - 0.54 9.1 8.6 0.74 8.6 8.6 1.2 1 0 0 1 1 1 0 Tumour-associated protein Galactosyl_T PF01762.19 MSTRG.18300.2_2 - 2e-38 132.0 0.0 2.8e-38 131.6 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase Ig_3 PF13927.4 MSTRG.25102.1_3 - 4.6e-19 68.7 1.6 9.5e-12 45.2 0.4 2.3 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 MSTRG.25102.1_3 - 1.2e-12 47.6 0.0 4.3e-10 39.4 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 MSTRG.25102.1_3 - 1.8e-08 34.3 0.1 0.00074 19.5 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.25102.1_3 - 2e-08 34.3 0.3 0.0012 19.0 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 MSTRG.25102.1_3 - 9.3e-05 22.4 1.9 0.23 11.5 0.1 3.4 2 1 1 3 3 3 1 Immunoglobulin V-set domain PH PF00169.27 MSTRG.9267.1_1 - 9.2e-21 74.2 0.0 7.2e-12 45.6 0.0 2.5 3 0 0 3 3 3 2 PH domain PH_8 PF15409.4 MSTRG.9267.1_1 - 5.3e-07 29.7 0.4 0.051 13.7 0.1 3.2 2 1 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.4 MSTRG.9267.1_1 - 7.9e-06 26.1 0.5 0.00048 20.4 0.1 3.2 2 2 0 2 2 2 1 Pleckstrin homology domain DHR-2 PF06920.11 MSTRG.18046.1_3 - 1.6e-142 475.7 11.9 1.9e-142 475.5 11.9 1.1 1 0 0 1 1 1 1 Dock homology region 2 G-patch PF01585.21 MSTRG.13760.3_1 - 2.8e-15 55.8 5.8 5.5e-15 54.9 5.8 1.5 1 0 0 1 1 1 1 G-patch domain FHA PF00498.24 MSTRG.13760.3_1 - 1.2e-14 54.3 0.0 2.3e-14 53.3 0.0 1.5 1 0 0 1 1 1 1 FHA domain G-patch_2 PF12656.5 MSTRG.13760.3_1 - 5.8e-07 29.4 0.8 5.8e-07 29.4 0.8 2.7 3 0 0 3 3 2 1 G-patch domain Yop-YscD_cpl PF16697.3 MSTRG.13760.3_1 - 1.2e-06 28.6 0.0 3e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain MIP-T3 PF10243.7 MSTRG.13760.3_1 - 0.00085 18.0 25.4 0.00085 18.0 25.4 2.7 3 0 0 3 3 3 1 Microtubule-binding protein MIP-T3 Atg14 PF10186.7 MSTRG.13760.3_1 - 0.0013 17.8 3.8 0.0013 17.8 3.8 2.4 2 0 0 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 Phage_GP20 PF06810.9 MSTRG.13760.3_1 - 0.034 13.8 7.5 0.09 12.4 7.5 1.7 1 0 0 1 1 1 0 Phage minor structural protein GP20 Bcr-Abl_Oligo PF09036.8 MSTRG.13760.3_1 - 0.044 13.6 1.5 0.11 12.4 1.5 1.6 1 0 0 1 1 1 0 Bcr-Abl oncoprotein oligomerisation domain DUF5104 PF17117.3 MSTRG.13760.3_1 - 0.16 12.3 4.1 0.57 10.5 4.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5104) Cnn_1N PF07989.9 MSTRG.13760.3_1 - 0.4 10.7 11.6 0.9 9.6 2.0 3.0 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 DUF1192 PF06698.9 MSTRG.13760.3_1 - 0.56 10.2 5.4 15 5.6 1.7 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) V_ATPase_I PF01496.17 MSTRG.13760.3_1 - 3.4 5.3 14.8 2.7 5.7 3.9 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family SAND PF01342.19 MSTRG.11863.1_1 - 1.3e-38 130.4 2.5 1.2e-20 72.8 0.4 2.4 2 0 0 2 2 2 2 SAND domain HSR PF03172.11 MSTRG.11863.1_1 - 2.5e-20 72.3 0.1 5.2e-20 71.3 0.1 1.6 1 0 0 1 1 1 1 HSR domain Bromodomain PF00439.23 MSTRG.11863.1_1 - 1.9e-13 50.2 0.0 6.7e-13 48.4 0.0 1.9 2 0 0 2 2 2 1 Bromodomain PHD PF00628.27 MSTRG.11863.1_1 - 2.6e-08 33.5 6.2 2.6e-08 33.5 6.2 2.4 2 0 0 2 2 2 1 PHD-finger VWA_2 PF13519.4 MSTRG.10658.1_3 - 0.086 13.4 0.0 0.16 12.5 0.0 1.4 1 0 0 1 1 1 0 von Willebrand factor type A domain FCH PF00611.21 MSTRG.27382.3_3 - 9.6e-16 57.7 1.3 9.6e-16 57.7 1.3 3.3 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.4 MSTRG.27382.3_3 - 2.3e-09 36.9 0.0 4.5e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.27382.3_3 - 3.6e-09 35.9 0.0 8e-09 34.8 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.27382.3_3 - 1.5e-06 27.6 0.0 2.8e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 MSTRG.27382.3_3 - 0.0034 17.5 0.0 0.0064 16.6 0.0 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain KxDL PF10241.7 MSTRG.27382.3_3 - 0.0078 16.3 1.9 0.0078 16.3 1.9 4.0 4 0 0 4 4 4 1 Uncharacterized conserved protein DUF1664 PF07889.10 MSTRG.27382.3_3 - 1.1 9.1 7.7 6.5 6.6 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Sema PF01403.17 MSTRG.13078.1_2 - 8.6e-143 476.0 0.0 1.2e-142 475.5 0.0 1.2 1 0 0 1 1 1 1 Sema domain Ig_3 PF13927.4 MSTRG.13078.1_2 - 1.5e-06 28.5 0.0 3.6e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.13078.1_2 - 4.8e-05 23.5 0.0 0.00013 22.2 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 MSTRG.13078.1_2 - 0.00017 21.5 0.0 0.00034 20.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 MSTRG.13078.1_2 - 0.00032 20.7 0.0 0.00077 19.5 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 MSTRG.13078.1_2 - 0.0046 17.0 0.1 0.062 13.3 0.1 2.3 1 1 0 1 1 1 1 Immunoglobulin V-set domain Neur_chan_LBD PF02931.21 MSTRG.3871.1_2 - 2.5e-68 229.6 0.4 3.9e-68 229.0 0.4 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 MSTRG.3871.1_2 - 1.6e-61 208.3 0.6 2.1e-61 207.9 0.6 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region PAP_assoc PF03828.17 MSTRG.5439.2_2 - 4.2e-15 55.6 0.1 1.1e-14 54.2 0.1 1.8 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.21 MSTRG.5439.2_2 - 5e-14 52.2 0.1 1.1e-13 51.1 0.1 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Myb_DNA-binding PF00249.29 MSTRG.5222.1_1 - 1.5e-09 37.7 0.2 3.3e-09 36.6 0.2 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain TRF PF08558.8 MSTRG.5222.1_1 - 8.4e-07 28.7 0.1 5.8e-06 25.9 0.1 2.0 1 1 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-bind_6 PF13921.4 MSTRG.5222.1_1 - 0.00036 20.6 0.1 0.0009 19.3 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain NYD-SP28_assoc PF14775.4 MSTRG.982.1_2 - 0.0016 18.3 0.5 0.0037 17.2 0.0 1.9 2 0 0 2 2 2 1 Sperm tail C-terminal domain Neuralized PF07177.10 MSTRG.982.1_2 - 0.15 11.9 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 Neuralized Aldolase_II PF00596.19 MSTRG.15107.4_2 - 1e-43 149.3 0.1 1.5e-43 148.7 0.1 1.3 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain MIP PF00230.18 MSTRG.20356.1_1 - 2.1e-60 204.1 6.3 3e-60 203.6 6.3 1.2 1 0 0 1 1 1 1 Major intrinsic protein MHC_I PF00129.16 MSTRG.16140.6_3 - 1.6e-19 70.1 0.1 2.1e-19 69.7 0.1 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 MSTRG.16140.6_3 - 1.7e-08 34.7 0.0 4.2e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Peptidase_Mx PF15887.3 MSTRG.16140.6_3 - 0.03 13.6 0.3 0.054 12.8 0.3 1.4 1 0 0 1 1 1 0 Putative zinc-binding metallo-peptidase TMEM51 PF15345.4 MSTRG.16140.6_3 - 0.1 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 TMEM154 PF15102.4 MSTRG.16140.6_3 - 0.11 12.3 0.1 0.26 11.0 0.1 1.6 1 0 0 1 1 1 0 TMEM154 protein family DUF3357 PF11837.6 MSTRG.16140.6_3 - 0.16 12.3 0.4 0.33 11.3 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) Ceramidase PF05875.10 MSTRG.11533.1_1 - 4.8e-56 190.0 10.5 6.9e-56 189.4 10.5 1.2 1 0 0 1 1 1 1 Ceramidase TSC22 PF01166.16 MSTRG.14836.1_3 - 5.5e-28 96.9 4.6 1.2e-27 95.8 4.6 1.6 1 0 0 1 1 1 1 TSC-22/dip/bun family DUF972 PF06156.11 MSTRG.14836.1_3 - 0.0047 17.4 1.3 0.011 16.2 1.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF972) DivIC PF04977.13 MSTRG.14836.1_3 - 0.026 14.1 1.9 0.069 12.8 1.9 1.7 1 0 0 1 1 1 0 Septum formation initiator K-box PF01486.15 MSTRG.14836.1_3 - 0.088 12.9 1.1 0.18 11.9 1.1 1.4 1 0 0 1 1 1 0 K-box region ZapB PF06005.10 MSTRG.14836.1_3 - 0.38 11.1 3.9 0.87 9.9 3.9 1.5 1 0 0 1 1 1 0 Cell division protein ZapB PH PF00169.27 MSTRG.18363.1_2 - 1.1e-15 57.9 2.3 2.3e-15 56.9 2.3 1.6 1 0 0 1 1 1 1 PH domain PDZ PF00595.22 MSTRG.18363.1_2 - 1.7e-06 28.1 0.3 3.5e-06 27.2 0.3 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PH_9 PF15410.4 MSTRG.18363.1_2 - 0.00043 20.5 3.2 0.0068 16.6 3.2 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain HIP1_clath_bdg PF16515.3 MSTRG.18363.1_2 - 0.13 12.7 1.3 0.36 11.3 0.7 2.0 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 PH_11 PF15413.4 MSTRG.18363.1_2 - 0.43 10.9 5.8 6.9 7.0 5.8 2.6 1 1 0 1 1 1 0 Pleckstrin homology domain L51_S25_CI-B8 PF05047.14 MSTRG.419.1_2 - 5.6e-10 38.8 0.0 1.2e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain TctC PF03401.12 MSTRG.419.1_2 - 0.091 11.7 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter family receptor DUF2740 PF10872.6 MSTRG.419.1_2 - 0.27 11.0 0.1 0.27 11.0 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2740) ESP PF16590.3 MSTRG.12881.2_1 - 0.097 12.8 0.0 11 6.3 0.0 4.3 7 0 0 7 7 7 0 Exocrine gland-secreting peptide zf-H2C2_2 PF13465.4 MSTRG.12881.2_2 - 9.7e-87 281.7 95.5 7.7e-08 32.3 1.0 13.4 13 0 0 13 13 13 13 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.12881.2_2 - 2.6e-61 200.6 105.3 8.5e-06 25.8 2.0 13.4 13 0 0 13 13 13 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.12881.2_2 - 3.4e-47 154.9 102.0 0.00062 20.2 0.9 13.7 14 0 0 14 14 13 13 C2H2-type zinc finger zf-LYAR PF08790.9 MSTRG.12881.2_2 - 1.7e-15 56.4 66.7 0.14 11.9 0.2 13.7 13 0 0 13 13 13 8 LYAR-type C2HC zinc finger zf-met PF12874.5 MSTRG.12881.2_2 - 1.9e-11 43.8 82.2 0.043 14.1 0.9 13.4 13 0 0 13 13 13 7 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 MSTRG.12881.2_2 - 3.8e-11 42.4 67.0 0.041 13.5 0.4 13.1 13 0 0 13 13 13 7 zinc-finger C2H2-type zf-C2HE PF16278.3 MSTRG.12881.2_2 - 2.5e-08 34.1 77.1 0.11 12.8 0.1 13.7 2 1 12 14 14 14 5 C2HE / C2H2 / C2HC zinc-binding finger zf-Di19 PF05605.10 MSTRG.12881.2_2 - 3.7e-08 33.4 44.3 0.0038 17.3 0.5 7.6 3 2 3 8 8 8 6 Drought induced 19 protein (Di19), zinc-binding LIM PF00412.20 MSTRG.12881.2_2 - 1.5e-06 28.2 58.7 0.58 10.3 2.2 11.8 3 3 8 11 11 11 2 LIM domain zinc_ribbon_15 PF17032.3 MSTRG.12881.2_2 - 3.8e-06 27.4 38.4 0.16 12.6 1.0 7.4 1 1 10 11 11 11 8 zinc-ribbon family zf-trcl PF13451.4 MSTRG.12881.2_2 - 3.9e-06 26.5 50.6 0.48 10.2 0.3 12.8 13 0 0 13 13 13 2 Probable zinc-ribbon domain Zn-ribbon_8 PF09723.8 MSTRG.12881.2_2 - 4.3e-06 26.6 50.0 0.82 9.7 0.9 9.0 4 2 5 10 10 10 7 Zinc ribbon domain BolA PF01722.16 MSTRG.12881.2_2 - 2.8e-05 24.2 23.3 2.2 8.5 0.6 8.2 4 4 2 6 6 6 1 BolA-like protein zf-H2C2_5 PF13909.4 MSTRG.12881.2_2 - 5.6e-05 22.7 73.5 0.021 14.5 0.1 12.5 13 0 0 13 13 12 5 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.5 MSTRG.12881.2_2 - 0.0019 18.3 49.9 1.3 9.3 0.6 11.3 1 1 10 11 11 11 2 C2H2 type zinc-finger (2 copies) HypA PF01155.17 MSTRG.12881.2_2 - 0.0021 17.9 39.7 7.1 6.5 0.8 7.9 1 1 7 8 8 8 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_jaz PF12171.6 MSTRG.12881.2_2 - 0.018 15.2 0.2 0.018 15.2 0.2 10.7 13 0 0 13 13 13 0 Zinc-finger double-stranded RNA-binding CNRIP1 PF15043.4 MSTRG.12881.2_2 - 0.058 12.8 9.1 12 5.3 0.0 5.5 4 3 3 7 7 7 0 CB1 cannabinoid receptor-interacting protein 1 zf-AN1 PF01428.14 MSTRG.12881.2_2 - 0.22 11.6 58.4 9 6.4 0.2 12.7 13 0 0 13 13 13 0 AN1-like Zinc finger DUF2180 PF09947.7 MSTRG.12881.2_2 - 0.26 11.2 23.0 1.6 8.7 0.3 6.7 3 3 3 7 7 7 0 Uncharacterized protein conserved in archaea (DUF2180) Elf1 PF05129.11 MSTRG.12881.2_2 - 0.28 11.1 54.6 0.37 10.7 1.6 8.1 1 1 10 11 11 11 0 Transcription elongation factor Elf1 like GAGA PF09237.9 MSTRG.12881.2_2 - 0.3 10.8 13.1 2.3 7.9 0.2 5.2 2 2 2 5 5 5 0 GAGA factor IBD PF10416.7 MSTRG.12881.2_2 - 0.67 9.8 5.3 34 4.3 0.0 5.0 2 2 2 6 6 6 0 Transcription-initiator DNA-binding domain IBD zf-HYPF PF07503.10 MSTRG.12881.2_2 - 1.6 8.5 44.2 8.5 6.1 0.0 11.5 11 1 1 12 12 12 0 HypF finger C1_2 PF03107.14 MSTRG.12881.2_2 - 3 8.1 62.9 7.4 6.8 0.2 12.0 2 2 5 8 8 7 0 C1 domain DUF3268 PF11672.6 MSTRG.12881.2_2 - 3.7 7.8 30.2 1.1 9.5 0.2 6.3 2 2 4 8 8 8 0 zinc-finger-containing domain Zn_ribbon_recom PF13408.4 MSTRG.12881.2_2 - 4.9 7.6 58.4 2.2 8.7 1.2 9.5 5 3 4 9 9 8 0 Recombinase zinc beta ribbon domain zf-C2H2_6 PF13912.4 MSTRG.12881.2_2 - 5.5 6.9 79.3 0.17 11.7 0.5 13.3 13 0 0 13 13 13 0 C2H2-type zinc finger PDZ PF00595.22 MSTRG.15215.2_3 - 4.3e-65 215.9 5.6 1.3e-14 54.1 0.0 6.4 6 0 0 6 6 6 6 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.15215.2_3 - 3.1e-25 88.1 0.3 0.00067 19.8 0.0 6.4 6 0 0 6 6 6 5 PDZ domain MAGI_u1 PF16663.3 MSTRG.15215.2_3 - 2e-24 85.2 2.0 7.8e-24 83.3 2.0 2.2 1 0 0 1 1 1 1 Unstructured region on MAGI WW PF00397.24 MSTRG.15215.2_3 - 2.6e-16 59.1 3.5 9.2e-10 38.2 0.3 2.5 2 0 0 2 2 2 2 WW domain Guanylate_kin PF00625.19 MSTRG.15215.2_3 - 3.8e-10 39.6 0.0 6.9e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase Tricorn_PDZ PF14685.4 MSTRG.15215.2_3 - 2.7e-06 27.2 5.6 1.1 9.2 0.1 5.8 6 0 0 6 6 6 2 Tricorn protease PDZ domain DUF4604 PF15377.4 MSTRG.15215.2_3 - 0.013 15.8 0.7 0.013 15.8 0.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) DUF3653 PF12375.6 MSTRG.7325.1_1 - 0.17 11.9 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 Phage protein Pept_tRNA_hydro PF01195.17 MSTRG.16198.1_2 - 3.9e-40 137.4 0.0 5.9e-40 136.8 0.0 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase Death PF00531.20 MSTRG.7423.2_1 - 0.0022 18.0 0.0 0.0036 17.3 0.0 1.2 1 0 0 1 1 1 1 Death domain CobS PF02654.13 MSTRG.7423.2_2 - 0.083 12.9 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 Cobalamin-5-phosphate synthase ERK-JNK_inhib PF15002.4 MSTRG.7969.3_1 - 6.2e-73 244.6 0.1 7.9e-73 244.2 0.1 1.1 1 0 0 1 1 1 1 ERK and JNK pathways, inhibitor RhoGAP PF00620.25 MSTRG.12731.1_3 - 1.7e-50 170.6 0.1 2.9e-50 169.9 0.1 1.4 1 0 0 1 1 1 1 RhoGAP domain PH_9 PF15410.4 MSTRG.12731.1_3 - 4.4e-11 43.1 0.0 8.5e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 MSTRG.12731.1_3 - 6.6e-09 36.1 0.0 1.7e-08 34.7 0.0 1.7 1 0 0 1 1 1 1 PH domain PDZ PF00595.22 MSTRG.12731.1_3 - 2.8e-08 33.9 0.0 6.6e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.12731.1_3 - 4.3e-06 26.8 0.0 1e-05 25.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PH_11 PF15413.4 MSTRG.12731.1_3 - 0.0021 18.3 0.0 0.0055 17.0 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PHR PF08005.10 MSTRG.1274.1_1 - 7.8e-46 156.3 0.1 1.2e-45 155.7 0.1 1.3 1 0 0 1 1 1 1 PHR domain DUF4082 PF13313.4 MSTRG.1274.1_1 - 0.039 13.9 0.0 0.066 13.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4082) LIM PF00412.20 MSTRG.23724.3_1 - 4.3e-16 58.7 1.1 2.4e-15 56.4 0.1 2.1 2 0 0 2 2 2 1 LIM domain zf-C3HC4_3 PF13920.4 MSTRG.23724.3_1 - 0.32 10.8 2.4 2.4 8.0 2.4 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) SET PF00856.26 MSTRG.954.1_1 - 3.1e-20 73.1 0.1 2.8e-19 70.0 0.2 2.5 2 2 0 2 2 2 1 SET domain PWWP PF00855.15 MSTRG.954.1_1 - 7.3e-18 64.7 0.2 1.8e-17 63.4 0.2 1.7 1 0 0 1 1 1 1 PWWP domain PHD PF00628.27 MSTRG.954.1_1 - 8.8e-16 57.4 64.2 7.9e-06 25.5 8.1 6.7 4 2 2 6 6 6 4 PHD-finger zf-HC5HC2H PF13771.4 MSTRG.954.1_1 - 0.0023 18.0 1.9 0.0023 18.0 1.9 6.6 4 2 3 7 7 7 4 PHD-like zinc-binding domain PHD_2 PF13831.4 MSTRG.954.1_1 - 0.053 12.9 38.1 0.012 15.0 4.8 5.3 5 0 0 5 5 5 0 PHD-finger Xpo1 PF08389.10 MSTRG.18682.1_2 - 2.2e-21 76.3 17.9 1.1e-19 70.8 0.0 6.7 7 1 0 7 7 7 2 Exportin 1-like protein IBN_N PF03810.17 MSTRG.18682.1_2 - 9.5e-08 31.7 0.4 4.1e-07 29.7 0.1 2.4 2 0 0 2 2 2 1 Importin-beta N-terminal domain Sulfotransfer_2 PF03567.12 MSTRG.14943.3_2 - 3e-27 96.0 0.1 4.1e-27 95.6 0.1 1.2 1 0 0 1 1 1 1 Sulfotransferase family Ion_trans PF00520.29 MSTRG.6282.1_2 - 7.5e-19 67.8 1.8 8.5e-19 67.6 1.8 1.0 1 0 0 1 1 1 1 Ion transport protein ATP-synt_B PF00430.16 MSTRG.6282.1_2 - 0.00066 19.6 2.0 0.00091 19.2 2.0 1.2 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) SieB PF14163.4 MSTRG.6282.1_2 - 0.0029 17.0 0.2 0.003 16.9 0.2 1.1 1 0 0 1 1 1 1 Super-infection exclusion protein B FixH PF05751.9 MSTRG.6282.1_2 - 0.016 15.1 0.1 0.021 14.7 0.1 1.1 1 0 0 1 1 1 0 FixH UPF0239 PF06783.9 MSTRG.6282.1_2 - 0.016 15.2 0.1 0.019 15.0 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) PepSY_2 PF13670.4 MSTRG.6282.1_2 - 0.022 14.6 0.0 0.033 14.0 0.0 1.2 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain DUF2309 PF10070.7 MSTRG.6282.1_2 - 0.036 12.3 0.1 0.036 12.3 0.1 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2309) Zip PF02535.20 MSTRG.6282.1_2 - 0.1 11.7 0.0 0.11 11.5 0.0 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4527 PF15030.4 MSTRG.6282.1_2 - 0.85 8.9 6.0 1 8.7 6.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4527) IlvB_leader PF08049.9 MSTRG.19350.1_1 - 3.5 7.4 14.7 6 6.6 14.7 1.3 1 0 0 1 1 1 0 IlvB leader peptide CNRIP1 PF15043.4 MSTRG.19350.1_2 - 4.8e-63 211.3 0.1 5.7e-63 211.0 0.1 1.1 1 0 0 1 1 1 1 CB1 cannabinoid receptor-interacting protein 1 FKBP_C PF00254.26 MSTRG.555.1_1 - 9e-27 93.1 0.0 1.1e-26 92.8 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Glutaminase PF04960.13 MSTRG.9170.1_3 - 1.4e-120 401.7 0.0 1.7e-120 401.4 0.0 1.1 1 0 0 1 1 1 1 Glutaminase Gelsolin PF00626.20 MSTRG.29706.1_2 - 8.8e-34 115.1 0.0 3.1e-20 71.7 0.0 2.1 2 0 0 2 2 2 2 Gelsolin repeat CHDCT2 PF08074.9 MSTRG.19754.3_1 - 1.2e-86 289.1 0.8 2.8e-86 287.9 0.8 1.7 1 0 0 1 1 1 1 CHDCT2 (NUC038) domain DUF1086 PF06461.9 MSTRG.19754.3_1 - 1.2e-60 203.3 0.1 2.9e-60 202.0 0.0 1.7 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1086) SNF2_N PF00176.21 MSTRG.19754.3_1 - 2.4e-58 197.4 0.2 7.5e-58 195.8 0.0 1.9 2 1 0 2 2 2 1 SNF2 family N-terminal domain DUF1087 PF06465.11 MSTRG.19754.3_1 - 1.3e-26 92.3 7.6 1.3e-26 92.3 7.6 2.3 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1087) Helicase_C PF00271.29 MSTRG.19754.3_1 - 2.3e-22 79.3 0.0 5.9e-22 78.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.19754.3_1 - 1.9e-09 37.6 0.0 8e-09 35.6 0.0 2.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.6 MSTRG.19754.3_1 - 0.0002 20.5 0.0 0.00049 19.2 0.0 1.6 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.27 MSTRG.19754.3_1 - 0.007 16.0 0.0 0.068 12.8 0.0 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase Cep57_MT_bd PF06657.11 MSTRG.19754.3_1 - 0.011 16.0 0.3 0.3 11.4 0.1 2.7 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 T3SS_basalb_I PF17001.3 MSTRG.19754.3_1 - 0.29 11.6 1.6 0.99 9.9 0.1 2.7 3 0 0 3 3 3 0 Type III secretion basal body protein I, YscI, HrpB, PscI SNF2_N PF00176.21 MSTRG.19754.3_2 - 1.1e-08 34.0 0.0 2.4e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.22 MSTRG.19754.3_2 - 0.0022 17.7 0.6 0.0043 16.8 0.6 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain CLASP_N PF12348.6 MSTRG.20727.3_2 - 1.2e-54 185.2 0.2 1.1e-38 132.9 0.2 2.2 2 0 0 2 2 2 2 CLASP N terminal HEAT PF02985.20 MSTRG.20727.3_2 - 1.7e-08 33.8 2.0 0.00066 19.6 0.0 6.1 7 0 0 7 7 7 1 HEAT repeat Sec7_N PF12783.5 MSTRG.20727.3_2 - 0.0002 21.2 0.3 0.26 11.1 0.0 3.3 3 0 0 3 3 3 2 Guanine nucleotide exchange factor in Golgi transport N-terminal Adaptin_N PF01602.18 MSTRG.20727.3_2 - 0.0018 16.7 0.0 1.6 7.0 0.0 3.2 3 0 0 3 3 3 2 Adaptin N terminal region Cnd1 PF12717.5 MSTRG.20727.3_2 - 0.0035 17.2 0.2 3.3 7.6 0.0 4.0 3 2 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.4 MSTRG.20727.3_2 - 0.0036 17.6 0.4 0.56 10.6 0.0 3.5 3 0 0 3 3 3 1 HEAT-like repeat Rotamase PF00639.19 MSTRG.27348.1_1 - 6.1e-24 84.7 0.0 1.1e-23 83.9 0.0 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.4 MSTRG.27348.1_1 - 2.7e-22 79.4 0.0 5e-22 78.5 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.24 MSTRG.27348.1_1 - 1.2e-12 47.4 1.1 1.6e-12 47.0 0.1 1.8 2 0 0 2 2 2 1 WW domain Rotamase_2 PF13145.4 MSTRG.27348.1_1 - 0.023 15.4 0.0 0.039 14.7 0.0 1.4 1 0 0 1 1 1 0 PPIC-type PPIASE domain EF-hand_1 PF00036.30 MSTRG.19581.1_1 - 3.1e-21 73.2 5.3 3.2e-07 29.3 0.1 5.5 5 0 0 5 5 5 5 EF hand EF-hand_7 PF13499.4 MSTRG.19581.1_1 - 9.9e-19 67.5 3.7 1.3e-08 35.0 1.3 3.3 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.19581.1_1 - 2.4e-17 61.2 4.9 1.2e-06 27.8 0.2 4.9 5 0 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.4 MSTRG.19581.1_1 - 5.5e-12 44.5 3.4 0.00076 18.8 0.1 3.4 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.4 MSTRG.19581.1_1 - 8.8e-12 44.5 1.0 0.00055 19.5 0.0 4.5 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_10 PF14788.4 MSTRG.19581.1_1 - 0.042 13.6 0.0 10 5.9 0.0 2.6 2 0 0 2 2 2 0 EF hand Gelsolin PF00626.20 MSTRG.15640.5_3 - 6.5e-20 70.7 0.0 2e-08 33.9 0.0 3.9 3 0 0 3 3 3 3 Gelsolin repeat DUF4695 PF15766.3 MSTRG.15640.5_3 - 0.00076 19.6 1.3 0.5 10.5 0.0 3.2 3 0 0 3 3 3 2 Domain of unknown function (DUF4695) RRM_1 PF00076.20 MSTRG.20036.3_2 - 1e-37 127.6 0.0 3.7e-23 81.0 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.4 MSTRG.20036.3_2 - 1.4e-26 93.2 0.2 3.5e-26 91.9 0.2 1.7 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.3 MSTRG.20036.3_2 - 0.0021 17.7 0.0 0.041 13.6 0.0 2.8 3 1 0 3 3 3 1 Occluded RNA-recognition motif RRM_5 PF13893.4 MSTRG.20036.3_2 - 0.019 14.5 0.0 0.28 10.7 0.0 2.3 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer PF06495.9 MSTRG.20036.3_2 - 0.31 11.0 36.9 0.016 15.2 30.5 2.0 2 0 0 2 2 2 0 Fruit fly transformer protein Apt1 PF10351.7 MSTRG.20036.3_2 - 2 7.1 10.5 2.8 6.5 10.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF1777 PF08648.10 MSTRG.20036.3_2 - 3.9 7.6 36.9 6.6 6.8 36.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) MIP-T3 PF10243.7 MSTRG.20036.3_2 - 5.1 5.6 26.9 7.7 5.0 26.9 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 eIF-5a PF01287.18 MSTRG.9031.2_3 - 1.5e-23 82.5 0.4 2.3e-23 82.0 0.4 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.10 MSTRG.9031.2_3 - 0.0059 16.5 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain LRR_8 PF13855.4 MSTRG.3571.1_1 - 1.1e-31 108.2 27.3 1.1e-10 41.0 7.9 7.5 4 2 2 7 7 7 6 Leucine rich repeat TIR PF01582.18 MSTRG.3571.1_1 - 2.8e-27 95.5 0.0 4.5e-27 94.8 0.0 1.2 1 0 0 1 1 1 1 TIR domain LRR_4 PF12799.5 MSTRG.3571.1_1 - 2.1e-22 78.6 32.8 4.8e-05 23.5 4.0 8.5 5 3 2 8 8 8 5 Leucine Rich repeats (2 copies) TIR_2 PF13676.4 MSTRG.3571.1_1 - 5.6e-11 42.5 0.0 1.1e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 TIR domain LRR_5 PF13306.4 MSTRG.3571.1_1 - 2e-06 27.7 0.3 2.4e-05 24.1 0.0 2.5 2 0 0 2 2 2 1 Leucine rich repeats (6 copies) LRR_9 PF14580.4 MSTRG.3571.1_1 - 2.1e-05 23.9 5.9 0.002 17.5 1.5 3.5 3 1 0 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.31 MSTRG.3571.1_1 - 0.00051 20.0 28.7 7.5 7.3 0.1 10.4 10 1 0 10 10 10 1 Leucine Rich Repeat DUF1863 PF08937.9 MSTRG.3571.1_1 - 0.0051 17.0 0.2 0.022 15.0 0.2 1.9 1 1 0 1 1 1 1 MTH538 TIR-like domain (DUF1863) LRR_6 PF13516.4 MSTRG.3571.1_1 - 2.4 8.3 30.9 11 6.3 0.0 9.3 10 0 0 10 10 10 0 Leucine Rich repeat ANTH PF07651.14 MSTRG.24579.1_3 - 2.2e-40 138.3 0.1 2.6e-40 138.0 0.1 1.1 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.18 MSTRG.24579.1_3 - 1e-10 41.6 0.1 1.4e-10 41.1 0.1 1.2 1 0 0 1 1 1 1 ENTH domain Beta_helix PF13229.4 MSTRG.25545.1_1 - 5.5e-10 39.2 1.9 6.6e-10 38.9 0.8 1.6 2 0 0 2 2 2 1 Right handed beta helix region NosD PF05048.11 MSTRG.25545.1_1 - 6.1e-05 22.3 0.4 0.0007 18.8 0.5 2.2 1 1 1 2 2 2 1 Periplasmic copper-binding protein (NosD) Pectate_lyase_3 PF12708.5 MSTRG.25545.1_1 - 0.00035 20.4 0.0 0.00082 19.2 0.0 1.6 1 0 0 1 1 1 1 Pectate lyase superfamily protein DUF4957 PF16318.3 MSTRG.25545.1_1 - 0.00065 19.5 0.2 0.96 9.3 0.1 2.6 1 1 1 2 2 2 2 Domain of unknown function (DUF4957) Beach PF02138.16 MSTRG.7807.1_3 - 8.4e-113 376.2 1.0 1.4e-112 375.5 1.0 1.3 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.4 MSTRG.7807.1_3 - 1.4e-20 73.1 0.0 6e-20 71.1 0.0 2.1 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH WD40 PF00400.30 MSTRG.7807.1_3 - 1.1e-06 29.1 13.8 0.08 13.7 0.2 5.7 4 1 1 5 5 5 4 WD domain, G-beta repeat DUF4800 PF16057.3 MSTRG.7807.1_3 - 0.0028 16.8 5.0 0.0063 15.7 5.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4800) GN3L_Grn1 PF08701.9 MSTRG.7807.1_3 - 0.012 15.6 0.7 0.027 14.4 0.7 1.5 1 0 0 1 1 1 0 GNL3L/Grn1 putative GTPase MAT1 PF06391.11 MSTRG.7807.1_3 - 0.95 9.1 5.1 2.3 7.8 5.1 1.6 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 DUF3694 PF12473.6 MSTRG.23918.1_1 - 4.8e-20 72.6 0.0 1.2e-19 71.3 0.0 1.7 1 0 0 1 1 1 1 Kinesin protein PH PF00169.27 MSTRG.23918.1_1 - 2e-12 47.4 0.0 5.7e-12 45.9 0.0 1.8 2 0 0 2 2 2 1 PH domain PH_11 PF15413.4 MSTRG.23918.1_1 - 0.033 14.5 0.1 0.11 12.8 0.1 1.9 1 1 0 1 1 1 0 Pleckstrin homology domain PH_9 PF15410.4 MSTRG.23918.1_1 - 0.07 13.4 0.5 0.33 11.2 0.1 2.2 2 1 0 2 2 2 0 Pleckstrin homology domain Pkinase_Tyr PF07714.15 MSTRG.14766.2_3 - 2.3e-103 344.9 0.0 3.1e-103 344.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.14766.2_3 - 1e-43 149.5 0.0 1.6e-43 148.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 MSTRG.14766.2_3 - 3.6e-36 123.0 0.0 6.5e-14 51.6 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.14766.2_3 - 1.6e-34 118.2 2.1 2.2e-11 44.1 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 MSTRG.14766.2_3 - 1.3e-23 82.8 0.9 8.3e-08 32.2 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.14766.2_3 - 3.9e-21 75.0 2.0 3.6e-07 30.3 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 MSTRG.14766.2_3 - 8.1e-16 58.0 2.6 2.6e-05 24.2 0.1 4.8 3 2 1 4 4 4 3 Immunoglobulin V-set domain Ig_5 PF16681.3 MSTRG.14766.2_3 - 2.3e-05 24.6 0.0 0.037 14.3 0.0 3.6 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 MSTRG.14766.2_3 - 0.00055 19.8 0.1 0.98 9.4 0.0 3.8 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain Ig_4 PF16680.3 MSTRG.14766.2_3 - 0.00064 19.9 0.0 0.38 11.0 0.0 3.3 3 0 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.10 MSTRG.14766.2_3 - 0.0012 18.7 0.1 0.027 14.4 0.0 2.8 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Kinase-like PF14531.4 MSTRG.14766.2_3 - 0.081 12.1 0.0 0.36 10.0 0.0 1.9 2 0 0 2 2 2 0 Kinase-like Y_phosphatase PF00102.25 MSTRG.13714.1_2 - 3.5e-164 543.8 7.9 2.1e-82 276.1 0.7 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.18 MSTRG.13714.1_2 - 2.6e-08 33.6 0.2 0.004 16.8 0.0 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 MSTRG.13714.1_2 - 3e-08 33.8 0.1 0.0011 18.8 0.0 2.6 3 0 0 3 3 3 2 Tyrosine phosphatase family PTPlike_phytase PF14566.4 MSTRG.13714.1_2 - 2.6e-05 24.3 0.2 0.058 13.4 0.0 2.6 2 0 0 2 2 2 2 Inositol hexakisphosphate EphA2_TM PF14575.4 MSTRG.13714.1_2 - 0.031 14.9 0.0 1.4 9.6 0.0 2.7 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.4 MSTRG.13714.1_2 - 0.047 13.5 0.3 0.21 11.4 0.0 2.1 2 0 0 2 2 2 0 TMEM154 protein family M16C_assoc PF08367.9 MSTRG.21345.3_3 - 1.9e-83 279.3 0.0 1.2e-82 276.6 0.0 2.0 2 0 0 2 2 2 1 Peptidase M16C associated Peptidase_M16_C PF05193.19 MSTRG.21345.3_3 - 3.3e-26 92.3 0.0 5.3e-20 72.1 0.0 2.6 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.18 MSTRG.21345.3_3 - 1.5e-09 37.9 0.2 3.3e-07 30.3 0.0 3.3 4 0 0 4 4 4 1 Insulinase (Peptidase family M16) ERM PF00769.17 MSTRG.24967.6_3 - 0.0027 17.4 16.9 0.0027 17.4 16.9 9.2 4 3 5 9 9 9 1 Ezrin/radixin/moesin family ABC_tran PF00005.25 MSTRG.6770.3_2 - 1.9e-44 151.4 11.2 9.7e-23 81.1 0.0 3.8 4 1 0 4 4 3 2 ABC transporter AAA_21 PF13304.4 MSTRG.6770.3_2 - 8.6e-15 55.2 6.4 0.00015 21.6 0.0 4.6 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.4 MSTRG.6770.3_2 - 2.4e-09 37.7 0.1 0.0006 20.2 0.0 4.2 2 1 0 3 3 3 2 AAA domain SMC_N PF02463.17 MSTRG.6770.3_2 - 1.1e-07 31.3 14.3 0.00024 20.5 0.0 4.8 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.4 MSTRG.6770.3_2 - 2.1e-06 27.2 0.0 0.0059 16.2 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.14 MSTRG.6770.3_2 - 5.3e-06 26.3 0.0 0.023 14.5 0.0 2.7 2 0 0 2 2 2 2 Protein of unknown function, DUF258 NACHT PF05729.10 MSTRG.6770.3_2 - 5.4e-06 26.3 0.0 0.059 13.2 0.0 2.5 2 0 0 2 2 2 2 NACHT domain ABC_tran_Xtn PF12848.5 MSTRG.6770.3_2 - 1.4e-05 24.9 14.2 1.4e-05 24.9 14.2 4.3 4 0 0 4 4 3 1 ABC transporter AAA_28 PF13521.4 MSTRG.6770.3_2 - 1.7e-05 25.0 0.0 0.11 12.6 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.4 MSTRG.6770.3_2 - 1.8e-05 24.5 0.5 0.27 10.8 0.0 3.2 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.4 MSTRG.6770.3_2 - 2.1e-05 24.8 0.0 0.17 12.2 0.1 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA PF00004.27 MSTRG.6770.3_2 - 4.1e-05 23.9 0.0 0.14 12.4 0.0 3.1 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.4 MSTRG.6770.3_2 - 5e-05 23.2 0.1 0.22 11.4 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.4 MSTRG.6770.3_2 - 5.8e-05 22.8 0.0 0.28 10.7 0.0 3.2 2 1 0 2 2 2 2 AAA domain AAA_22 PF13401.4 MSTRG.6770.3_2 - 6.8e-05 23.0 0.2 0.28 11.3 0.1 3.2 2 1 0 2 2 2 2 AAA domain AAA_5 PF07728.12 MSTRG.6770.3_2 - 0.00037 20.4 0.1 1.3 8.9 0.1 2.8 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) RNA_helicase PF00910.20 MSTRG.6770.3_2 - 0.00043 20.5 0.3 2.1 8.6 0.0 3.1 3 0 0 3 3 2 2 RNA helicase MMR_HSR1 PF01926.21 MSTRG.6770.3_2 - 0.0022 17.9 0.3 0.66 10.0 0.0 3.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_23 PF13476.4 MSTRG.6770.3_2 - 0.003 18.0 0.0 0.003 18.0 0.0 5.6 5 1 0 5 5 3 2 AAA domain NTPase_1 PF03266.13 MSTRG.6770.3_2 - 0.0032 17.3 0.2 3.2 7.5 0.0 2.8 3 0 0 3 3 2 2 NTPase Roc PF08477.11 MSTRG.6770.3_2 - 0.0034 17.5 0.0 3.3 7.8 0.0 2.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.17 MSTRG.6770.3_2 - 0.0034 16.9 0.1 0.23 10.9 0.0 2.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.4 MSTRG.6770.3_2 - 0.0037 17.3 0.1 2.2 8.3 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.4 MSTRG.6770.3_2 - 0.0068 15.9 0.1 3 7.2 0.0 3.1 3 0 0 3 3 3 1 AAA domain DUF2572 PF10833.6 MSTRG.6770.3_2 - 0.007 16.0 0.8 0.021 14.5 0.8 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2572) IstB_IS21 PF01695.15 MSTRG.6770.3_2 - 0.15 11.7 1.0 8 6.1 0.0 3.1 3 1 0 3 3 3 0 IstB-like ATP binding protein CD36 PF01130.19 MSTRG.19646.3_3 - 9e-114 380.4 0.3 1e-113 380.2 0.3 1.0 1 0 0 1 1 1 1 CD36 family Ldl_recept_a PF00057.16 MSTRG.14110.2_3 - 1.6e-38 130.4 89.5 7.4e-13 48.3 13.9 10.7 12 0 0 12 12 12 5 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.15 MSTRG.14110.2_3 - 3.3e-36 123.4 4.8 2e-14 53.7 0.0 5.5 5 0 0 5 5 5 4 Low-density lipoprotein receptor repeat class B hEGF PF12661.5 MSTRG.14110.2_3 - 0.00012 22.5 7.1 0.00012 22.5 7.1 14.6 13 1 0 13 13 13 5 Human growth factor-like EGF EGF_CA PF07645.13 MSTRG.14110.2_3 - 0.00026 21.0 10.1 0.00026 21.0 10.1 13.8 6 2 8 14 14 14 1 Calcium-binding EGF domain EGF PF00008.25 MSTRG.14110.2_3 - 0.00035 20.7 12.2 0.00035 20.7 12.2 14.9 15 1 0 15 15 15 5 EGF-like domain cEGF PF12662.5 MSTRG.14110.2_3 - 0.0029 17.4 2.4 0.0029 17.4 2.4 8.5 7 0 0 7 7 7 2 Complement Clr-like EGF-like EGF_2 PF07974.11 MSTRG.14110.2_3 - 0.0033 17.6 9.9 0.0033 17.6 9.9 13.7 12 2 1 13 13 13 4 EGF-like domain TadE PF07811.10 MSTRG.14110.2_3 - 0.025 14.7 2.1 0.061 13.5 2.1 1.6 1 0 0 1 1 1 0 TadE-like protein SKG6 PF08693.8 MSTRG.14110.2_3 - 0.36 10.1 1.3 0.69 9.2 1.3 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain RhoGEF PF00621.18 MSTRG.5147.1_2 - 4.6e-07 30.1 0.0 5.3e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 RhoGEF domain BACK PF07707.13 MSTRG.22973.1_2 - 3.2e-29 100.9 0.4 5.5e-29 100.2 0.4 1.4 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.29 MSTRG.22973.1_2 - 6.4e-27 93.8 0.7 8e-25 87.1 0.3 2.3 1 1 1 2 2 2 1 BTB/POZ domain Kelch_1 PF01344.23 MSTRG.22973.1_2 - 1.8e-19 68.9 0.9 6e-11 41.6 0.0 5.3 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.4 MSTRG.22973.1_2 - 3.1e-15 55.7 0.6 2.5e-05 24.3 0.0 4.5 2 1 2 4 4 4 3 Kelch motif Kelch_2 PF07646.13 MSTRG.22973.1_2 - 1.8e-13 49.8 2.4 0.00022 20.9 0.0 5.1 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.4 MSTRG.22973.1_2 - 2.3e-06 27.6 1.1 0.13 12.4 0.3 3.9 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_4 PF13418.4 MSTRG.22973.1_2 - 4.3e-05 23.2 0.1 0.37 10.7 0.0 3.6 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.4 MSTRG.22973.1_2 - 0.00048 19.9 2.8 0.42 10.5 0.0 4.0 4 0 0 4 4 4 1 Kelch motif DUF3342 PF11822.6 MSTRG.22973.1_2 - 0.00081 19.4 0.2 0.14 12.3 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3342) DUF4588 PF15251.4 MSTRG.27388.1_1 - 6.7e-95 317.5 0.0 9.5e-95 317.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4588) Proteasom_PSMB PF10508.7 MSTRG.12013.2_2 - 1.2e-174 581.4 1.0 1.4e-174 581.2 1.0 1.0 1 0 0 1 1 1 1 Proteasome non-ATPase 26S subunit RICTOR_V PF14668.4 MSTRG.12013.2_2 - 5.4e-05 23.2 0.2 1.7 8.8 0.0 4.4 2 1 3 5 5 5 3 Rapamycin-insensitive companion of mTOR, domain 5 HEAT_2 PF13646.4 MSTRG.12013.2_2 - 5.7e-05 23.3 0.0 0.024 14.9 0.0 3.6 2 1 1 3 3 3 1 HEAT repeats V-ATPase_H_C PF11698.6 MSTRG.12013.2_2 - 0.0031 17.5 4.4 0.16 11.9 0.6 3.7 3 1 0 3 3 3 1 V-ATPase subunit H TIP120 PF08623.8 MSTRG.12013.2_2 - 0.0032 17.1 2.0 3.2 7.4 0.0 3.3 3 0 0 3 3 3 1 TATA-binding protein interacting (TIP20) Cnd1 PF12717.5 MSTRG.12013.2_2 - 0.093 12.6 7.0 1.4 8.8 1.3 3.4 2 1 2 4 4 4 0 non-SMC mitotic condensation complex subunit 1 STAG PF08514.9 MSTRG.12013.2_2 - 0.099 12.4 0.3 5.2 6.9 0.0 2.9 2 0 0 2 2 2 0 STAG domain RNase_T PF00929.22 MSTRG.9801.1_1 - 5.9e-11 43.1 0.0 1.1e-10 42.1 0.0 1.5 1 1 0 1 1 1 1 Exonuclease DUF5051 PF16473.3 MSTRG.9801.1_1 - 3.2e-08 33.6 0.0 8e-08 32.3 0.0 1.6 1 1 0 1 1 1 1 3' exoribonuclease, RNase T-like RNase_H_2 PF13482.4 MSTRG.9801.1_1 - 0.0015 18.4 0.7 0.13 12.1 0.0 2.6 2 1 1 3 3 3 2 RNase_H superfamily Troponin PF00992.18 MSTRG.22590.2_3 - 8e-32 110.2 42.9 1.6e-28 99.5 37.9 2.2 1 1 1 2 2 2 2 Troponin Peptidase_S64 PF08192.9 MSTRG.22590.2_3 - 1.1 7.6 9.6 1.4 7.1 9.6 1.1 1 0 0 1 1 1 0 Peptidase family S64 zf-CCHC PF00098.21 MSTRG.22590.2_3 - 4.7 7.3 5.7 1.4e+02 2.7 5.7 3.1 1 1 0 1 1 1 0 Zinc knuckle Neurexophilin PF06312.10 MSTRG.22307.1_2 - 1.1e-31 109.9 0.0 1.6e-31 109.3 0.0 1.2 1 0 0 1 1 1 1 Neurexophilin Filamin PF00630.17 MSTRG.22307.1_2 - 0.053 14.2 0.0 0.13 12.9 0.0 1.6 1 0 0 1 1 1 0 Filamin/ABP280 repeat BAH PF01426.16 MSTRG.25957.4_3 - 2.6e-28 98.2 0.2 4.8e-28 97.3 0.2 1.5 1 0 0 1 1 1 1 BAH domain ELM2 PF01448.22 MSTRG.25957.4_3 - 3.6e-16 59.5 0.2 8.1e-16 58.4 0.2 1.6 1 0 0 1 1 1 1 ELM2 domain GATA PF00320.25 MSTRG.25957.4_3 - 2.2e-11 43.0 7.8 6.9e-11 41.5 7.8 1.9 1 0 0 1 1 1 1 GATA zinc finger Myb_DNA-binding PF00249.29 MSTRG.25957.4_3 - 0.00019 21.4 0.0 0.00046 20.1 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.3 MSTRG.25957.4_3 - 0.031 14.0 0.1 0.076 12.8 0.1 1.6 1 0 0 1 1 1 0 Myb DNA-binding like Ribosomal_L39 PF00832.18 MSTRG.8069.3_1 - 0.55 9.8 6.7 0.48 10.0 0.9 2.6 2 0 0 2 2 2 0 Ribosomal L39 protein Homeobox PF00046.27 MSTRG.8069.3_3 - 1.2e-21 76.1 1.7 2.2e-21 75.3 1.7 1.4 1 0 0 1 1 1 1 Homeobox domain YdaS_antitoxin PF15943.3 MSTRG.8069.3_3 - 0.065 13.0 0.3 2.8 7.8 0.0 2.3 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Snf7 PF03357.19 MSTRG.8449.1_1 - 2e-11 43.7 17.0 3e-11 43.1 17.0 1.1 1 0 0 1 1 1 1 Snf7 FliG_N PF14842.4 MSTRG.8449.1_1 - 0.073 13.5 1.5 0.14 12.5 1.5 1.4 1 0 0 1 1 1 0 FliG N-terminal domain Ist1 PF03398.12 MSTRG.8449.1_1 - 0.79 9.5 8.9 1.3 8.8 8.9 1.3 1 0 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway SmAKAP PF15127.4 MSTRG.9181.2_3 - 3.1e-19 69.8 0.9 6.9e-18 65.5 0.9 2.2 1 1 0 1 1 1 1 Small membrane A-kinase anchor protein AMP-binding PF00501.26 MSTRG.404.1_2 - 1.2e-109 366.6 0.0 1.5e-109 366.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 MSTRG.404.1_2 - 2.4e-05 25.1 0.0 6.4e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain zf-CCCH_2 PF14608.4 MSTRG.16441.3_1 - 1.5e-10 41.0 63.3 3.4e-05 24.0 5.4 5.6 5 0 0 5 5 5 5 RNA-binding, Nab2-type zinc finger PWI PF01480.15 MSTRG.16441.3_1 - 0.017 15.3 0.1 0.029 14.5 0.1 1.3 1 0 0 1 1 1 0 PWI domain SAM_1 PF00536.28 MSTRG.24265.5_3 - 6.4e-18 64.8 0.1 1.1e-17 64.0 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Glycos_trans_3N PF02885.15 MSTRG.24265.5_3 - 7.5e-18 64.0 0.0 1.2e-17 63.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain SAM_2 PF07647.15 MSTRG.24265.5_3 - 2.8e-11 43.2 0.1 5.2e-11 42.4 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Glycos_transf_3 PF00591.19 MSTRG.24265.5_3 - 0.0037 16.8 0.5 0.0048 16.4 0.5 1.2 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain HlyIII PF03006.18 MSTRG.14144.2_1 - 2.3e-72 243.2 18.1 3.2e-72 242.8 18.1 1.2 1 0 0 1 1 1 1 Haemolysin-III related Atg8 PF02991.14 MSTRG.7318.1_1 - 2e-34 117.8 0.0 2.8e-34 117.3 0.0 1.2 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.11 MSTRG.7318.1_1 - 0.011 16.0 0.0 0.018 15.3 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-like autophagy protein Apg12 PX PF00787.22 MSTRG.25340.1_3 - 6.2e-20 71.2 0.1 1.4e-19 70.0 0.1 1.6 1 0 0 1 1 1 1 PX domain DUF641 PF04859.10 MSTRG.25340.1_3 - 0.0013 18.9 0.2 0.0061 16.7 0.4 1.9 2 0 0 2 2 2 1 Plant protein of unknown function (DUF641) Fib_alpha PF08702.8 MSTRG.25340.1_3 - 0.011 15.8 0.9 0.022 14.8 0.9 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family CEP209_CC5 PF16574.3 MSTRG.25340.1_3 - 0.088 12.8 2.8 0.15 12.1 2.8 1.3 1 0 0 1 1 1 0 Coiled-coil region of centrosome protein CE290 ADIP PF11559.6 MSTRG.25340.1_3 - 0.26 11.2 3.1 0.49 10.3 3.1 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding OST3_OST6 PF04756.11 MSTRG.11483.1_1 - 1.1e-82 277.6 0.1 1.4e-82 277.3 0.1 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin PF00085.18 MSTRG.11483.1_1 - 4.6e-06 26.4 0.0 6.6e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin YhhN PF07947.12 MSTRG.11483.1_1 - 0.046 13.2 0.0 0.11 11.9 0.0 1.6 1 0 0 1 1 1 0 YhhN family DUF4131 PF13567.4 MSTRG.11483.1_1 - 0.069 12.6 0.1 0.31 10.5 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) zf-C2H2_4 PF13894.4 MSTRG.18555.1_3 - 2.4e-07 30.9 12.1 0.00074 20.0 3.2 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.24 MSTRG.18555.1_3 - 7.9e-07 29.1 14.7 0.0015 18.8 4.6 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.18555.1_3 - 0.0013 19.0 1.1 0.0013 19.0 1.1 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.4 MSTRG.18555.1_3 - 0.0075 16.1 10.5 0.04 13.7 2.4 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_2 PF12756.5 MSTRG.18555.1_3 - 0.016 15.4 9.3 0.17 12.1 1.2 2.3 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_9 PF16293.3 MSTRG.18555.1_3 - 0.058 13.1 5.1 0.24 11.1 0.6 2.4 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) zf-Di19 PF05605.10 MSTRG.18555.1_3 - 0.06 13.5 3.0 1.5 9.0 0.3 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding CpXC PF14353.4 MSTRG.18555.1_3 - 0.1 12.5 1.4 0.81 9.6 0.1 2.1 1 1 0 1 1 1 0 CpXC protein zf-C2H2_jaz PF12171.6 MSTRG.18555.1_3 - 0.98 9.7 9.9 1 9.6 1.3 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-BED PF02892.13 MSTRG.18555.1_3 - 1.4 8.9 8.2 3.6 7.6 1.0 2.8 2 0 0 2 2 2 0 BED zinc finger I-set PF07679.14 MSTRG.219.1_1 - 6e-31 106.2 0.1 1.6e-17 63.2 0.0 2.0 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.219.1_1 - 1.7e-20 73.3 0.0 1.6e-09 38.1 0.0 2.1 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 MSTRG.219.1_1 - 2.9e-14 52.9 0.0 4.6e-07 29.8 0.0 2.1 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.219.1_1 - 1.3e-13 51.0 0.0 1.4e-05 25.2 0.0 2.1 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 MSTRG.219.1_1 - 1.1e-10 41.5 0.0 0.0037 17.3 0.0 3.0 2 1 1 3 3 3 3 Immunoglobulin V-set domain C1-set PF07654.13 MSTRG.219.1_1 - 3.2e-06 27.4 0.0 0.0069 16.7 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin C1-set domain Adeno_E3_CR1 PF02440.13 MSTRG.219.1_1 - 4.7e-05 23.0 0.0 0.035 13.8 0.0 2.2 2 0 0 2 2 2 2 Adenovirus E3 region protein CR1 C2-set_2 PF08205.10 MSTRG.219.1_1 - 0.0018 18.2 0.0 0.044 13.7 0.0 2.1 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain V-set_CD47 PF08204.9 MSTRG.219.1_1 - 0.018 14.9 0.0 0.92 9.4 0.1 2.1 1 1 1 2 2 2 0 CD47 immunoglobulin-like domain DAGK_cat PF00781.22 MSTRG.11717.1_2 - 1.2e-05 24.8 0.0 2.1e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain FGE-sulfatase PF03781.14 MSTRG.24059.1_1 - 5.6e-60 203.0 2.2 8.4e-60 202.4 2.2 1.3 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 CBFD_NFYB_HMF PF00808.21 MSTRG.23571.2_2 - 0.00022 21.3 0.1 0.00052 20.1 0.1 1.7 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Fic PF02661.16 MSTRG.3058.1_3 - 2.1e-26 92.5 0.0 4.8e-26 91.3 0.0 1.6 1 0 0 1 1 1 1 Fic/DOC family TPR_2 PF07719.15 MSTRG.3058.1_3 - 2.3e-06 27.2 0.2 0.043 13.8 0.5 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.3058.1_3 - 0.0022 17.6 0.0 0.39 10.5 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.3058.1_3 - 0.0056 16.2 0.8 0.085 12.4 0.0 2.6 3 0 0 3 3 3 1 TPR repeat TPR_14 PF13428.4 MSTRG.3058.1_3 - 0.0071 17.0 0.2 0.042 14.5 0.1 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.3058.1_3 - 0.0092 16.2 0.0 0.066 13.5 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat NARP1 PF12569.6 MSTRG.3058.1_3 - 0.053 12.3 0.3 0.093 11.5 0.3 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TPR_16 PF13432.4 MSTRG.3058.1_3 - 0.067 13.8 0.0 0.17 12.5 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.3058.1_3 - 0.073 13.5 0.3 0.35 11.3 0.1 1.9 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.3058.1_3 - 0.29 11.3 1.4 33 4.7 0.0 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat Ets PF00178.20 MSTRG.26690.2_3 - 2.4e-35 120.7 1.4 3.7e-35 120.1 1.4 1.3 1 0 0 1 1 1 1 Ets-domain TMEM214 PF10151.7 MSTRG.19962.1_1 - 1.6e-247 823.1 6.3 1.9e-247 822.9 6.3 1.0 1 0 0 1 1 1 1 TMEM214, C-terminal, caspase 4 activator zf-H2C2_2 PF13465.4 MSTRG.15567.1_3 - 1.8e-17 62.7 20.6 5.8e-08 32.7 1.8 5.0 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.15567.1_3 - 4e-11 42.6 30.0 1.1e-06 28.6 1.1 4.3 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_11 PF16622.3 MSTRG.15567.1_3 - 3.2e-06 26.6 9.8 0.0047 16.5 0.8 3.8 3 0 0 3 3 3 2 zinc-finger C2H2-type zf-C2H2_4 PF13894.4 MSTRG.15567.1_3 - 5.5e-06 26.6 31.4 0.00011 22.6 0.9 5.2 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.15567.1_3 - 1.1e-05 25.1 16.2 0.018 14.8 0.7 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2HE PF16278.3 MSTRG.15567.1_3 - 0.00013 22.2 10.7 0.02 15.2 0.6 3.7 1 1 2 3 3 3 2 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_jaz PF12171.6 MSTRG.15567.1_3 - 0.00042 20.4 9.2 0.0023 18.1 0.2 3.7 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.15567.1_3 - 0.00061 19.9 7.1 0.069 13.4 1.1 3.8 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-LYAR PF08790.9 MSTRG.15567.1_3 - 0.0015 18.3 6.5 2.3 8.1 0.1 4.4 4 0 0 4 4 4 1 LYAR-type C2HC zinc finger DAP PF15228.4 MSTRG.15567.1_3 - 0.047 14.7 0.1 0.077 14.0 0.1 1.4 1 0 0 1 1 1 0 Death-associated protein Robl_LC7 PF03259.15 MSTRG.12566.1_2 - 1.5e-17 63.0 0.1 2.1e-17 62.6 0.1 1.2 1 0 0 1 1 1 1 Roadblock/LC7 domain zf-CXXC PF02008.18 MSTRG.13088.2_1 - 3.1e-06 27.0 16.9 9.3e-06 25.4 16.9 1.9 1 0 0 1 1 1 1 CXXC zinc finger domain MBD PF01429.17 MSTRG.13088.2_2 - 4.3e-11 42.2 0.0 1.1e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 Methyl-CpG binding domain Sugar_tr PF00083.22 MSTRG.4262.1_3 - 7.4e-34 117.2 22.5 1e-33 116.8 22.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 MSTRG.4262.1_3 - 3.3e-29 101.8 36.1 4.2e-25 88.3 23.0 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily zf-H2C2_2 PF13465.4 MSTRG.3694.1_2 - 2.6e-39 131.8 77.6 2e-07 31.0 0.2 12.1 12 0 0 12 12 12 9 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.3694.1_2 - 9.6e-36 120.1 77.8 3e-05 24.1 2.1 10.3 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.3694.1_2 - 6.1e-31 104.3 75.2 0.0015 19.0 1.8 10.3 10 0 0 10 10 10 10 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.3694.1_2 - 1.4e-14 53.8 31.4 0.064 13.4 0.1 9.4 9 0 0 9 9 9 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.3694.1_2 - 5.6e-13 48.7 54.5 0.0031 17.7 0.6 9.1 9 0 0 9 9 9 5 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 MSTRG.3694.1_2 - 1.2e-07 31.4 59.7 0.026 14.3 0.6 10.4 10 0 0 10 10 10 6 C2H2-type zinc finger FYVE PF01363.19 MSTRG.3694.1_2 - 0.0019 18.1 9.0 0.0019 18.1 9.0 6.1 2 1 2 4 4 3 1 FYVE zinc finger ADK_lid PF05191.12 MSTRG.3694.1_2 - 0.0026 17.6 2.3 0.0026 17.6 2.3 6.0 5 2 1 6 6 6 1 Adenylate kinase, active site lid zf-C2H2_11 PF16622.3 MSTRG.3694.1_2 - 0.035 13.7 1.0 0.035 13.7 1.0 8.9 10 0 0 10 10 10 0 zinc-finger C2H2-type Chordopox_A33R PF05966.10 MSTRG.3694.1_2 - 0.057 12.5 0.0 0.12 11.6 0.0 1.5 1 0 0 1 1 1 0 Chordopoxvirus A33R protein SPT6_acidic PF14632.4 MSTRG.3694.1_2 - 0.061 13.8 8.0 0.48 10.9 1.5 2.5 2 0 0 2 2 2 0 Acidic N-terminal SPT6 Zn-ribbon_8 PF09723.8 MSTRG.3694.1_2 - 0.07 13.1 0.6 0.07 13.1 0.6 6.4 4 2 2 6 6 6 0 Zinc ribbon domain Peptidase_S68 PF10461.7 MSTRG.3694.1_2 - 0.1 12.7 1.0 0.84 9.8 1.0 2.6 1 0 0 1 1 1 0 Peptidase S68 Ta0938 PF11494.6 MSTRG.3694.1_2 - 2.5 8.3 11.0 1.4 9.1 0.1 4.6 2 2 6 8 8 8 0 Ta0938 YqzM PF14141.4 MSTRG.18042.1_3 - 0.12 12.3 1.8 0.27 11.1 1.8 1.5 1 0 0 1 1 1 0 YqzM-like protein Pkinase PF00069.23 MSTRG.10895.1_1 - 6.6e-40 137.0 0.0 1.1e-39 136.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.10895.1_1 - 1.1e-24 87.1 0.0 1.6e-24 86.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.10895.1_1 - 0.041 13.1 0.0 3.2 6.9 0.0 2.1 2 0 0 2 2 2 0 Kinase-like PMP22_Claudin PF00822.18 MSTRG.3884.1_1 - 0.0018 18.0 0.5 0.0024 17.6 0.5 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family FragX_IP PF05994.9 MSTRG.24000.1_3 - 0 1313.0 0.9 0 1313.0 0.9 1.8 2 0 0 2 2 2 1 Cytoplasmic Fragile-X interacting family DUF1394 PF07159.10 MSTRG.24000.1_3 - 1.7e-08 34.0 2.7 3.9e-08 32.8 2.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) Spore_SspJ PF09575.8 MSTRG.24000.1_3 - 0.088 13.1 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 Small spore protein J (Spore_SspJ) zinc_ribbon_12 PF11331.6 MSTRG.20870.1_2 - 0.21 11.2 5.4 0.44 10.2 5.4 1.7 1 1 0 1 1 1 0 Probable zinc-ribbon domain DUF2043 PF09740.7 MSTRG.18173.2_1 - 1.4e-23 83.4 0.0 3e-23 82.4 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2043) YEATS PF03366.14 MSTRG.29253.1_2 - 1.6e-15 56.8 0.1 2.9e-15 55.9 0.1 1.5 1 0 0 1 1 1 1 YEATS family DUF5082 PF16888.3 MSTRG.29253.1_2 - 0.0022 18.2 0.8 0.003 17.8 0.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5082) SOGA PF11365.6 MSTRG.29253.1_2 - 0.0045 17.9 3.1 0.0076 17.2 3.1 1.3 1 0 0 1 1 1 1 Protein SOGA DUF1664 PF07889.10 MSTRG.29253.1_2 - 0.0082 16.0 1.4 0.011 15.6 1.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) DUF342 PF03961.11 MSTRG.29253.1_2 - 0.039 12.4 1.7 0.045 12.2 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) PMSR PF01625.19 MSTRG.29253.1_2 - 0.042 13.9 1.3 0.14 12.2 0.6 1.8 1 1 1 2 2 2 0 Peptide methionine sulfoxide reductase Ax_dynein_light PF10211.7 MSTRG.29253.1_2 - 0.078 12.8 5.7 0.12 12.2 5.7 1.4 1 1 0 1 1 1 0 Axonemal dynein light chain CENP-H PF05837.10 MSTRG.29253.1_2 - 0.12 12.7 3.3 0.16 12.2 3.3 1.2 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Exonuc_VII_L PF02601.13 MSTRG.29253.1_2 - 0.13 11.7 1.1 0.16 11.4 1.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DivIC PF04977.13 MSTRG.29253.1_2 - 0.3 10.7 4.2 0.52 10.0 4.2 1.4 1 0 0 1 1 1 0 Septum formation initiator IncA PF04156.12 MSTRG.29253.1_2 - 0.5 10.0 3.2 0.65 9.6 3.2 1.2 1 0 0 1 1 1 0 IncA protein Pkinase PF00069.23 MSTRG.20591.1_3 - 5.3e-48 163.5 0.0 7e-48 163.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.20591.1_3 - 4.3e-18 65.4 0.0 6.4e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.20591.1_3 - 3.8e-06 26.3 0.0 5.3e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like MMACHC PF16690.3 MSTRG.23761.1_2 - 1.2e-96 322.4 0.0 1.5e-96 322.2 0.0 1.0 1 0 0 1 1 1 1 Methylmalonic aciduria and homocystinuria type C family Fzo_mitofusin PF04799.11 MSTRG.13553.1_2 - 1.6e-73 245.4 13.0 3.5e-73 244.3 8.1 2.8 2 1 0 2 2 2 1 fzo-like conserved region Dynamin_N PF00350.21 MSTRG.13553.1_2 - 1.2e-24 87.1 2.5 2.8e-24 85.9 0.0 2.7 3 0 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.21 MSTRG.13553.1_2 - 6.6e-08 32.5 0.0 3.1e-07 30.3 0.0 2.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase LMP PF04778.10 MSTRG.13553.1_2 - 0.0048 16.7 0.4 0.0048 16.7 0.4 2.2 2 0 0 2 2 2 1 LMP repeated region Synaptobrevin PF00957.19 MSTRG.13553.1_2 - 0.0048 16.5 1.2 0.032 13.9 1.3 2.3 2 0 0 2 2 2 1 Synaptobrevin CorA PF01544.16 MSTRG.13553.1_2 - 0.054 12.7 5.6 0.23 10.6 0.2 2.5 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein AzlD PF05437.10 MSTRG.13553.1_2 - 0.061 13.4 0.4 0.13 12.3 0.4 1.5 1 0 0 1 1 1 0 Branched-chain amino acid transport protein (AzlD) Baculo_PEP_C PF04513.10 MSTRG.13553.1_2 - 0.071 13.0 3.6 4.1 7.3 0.3 2.8 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus T2SSE PF00437.18 MSTRG.13553.1_2 - 0.085 11.8 2.4 1.2 8.0 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein COG2 PF06148.9 MSTRG.13553.1_2 - 0.74 9.8 9.9 0.61 10.0 2.6 2.9 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Nup54 PF13874.4 MSTRG.13553.1_2 - 1 9.3 13.6 0.18 11.8 5.3 2.7 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Phage_GP20 PF06810.9 MSTRG.13553.1_2 - 1.1 8.9 7.4 1.6 8.3 1.3 2.6 2 0 0 2 2 2 0 Phage minor structural protein GP20 DUF5082 PF16888.3 MSTRG.13553.1_2 - 1.2 9.4 6.2 0.95 9.7 1.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) YscO PF07321.10 MSTRG.13553.1_2 - 2 8.2 18.4 0.024 14.5 6.7 2.7 2 1 1 3 3 3 0 Type III secretion protein YscO DUF1664 PF07889.10 MSTRG.13553.1_2 - 3.9 7.3 14.0 0.29 11.0 1.0 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) Laminin_II PF06009.10 MSTRG.13553.1_2 - 5.4 6.9 9.5 4 7.3 1.4 2.7 2 0 0 2 2 2 0 Laminin Domain II Cyclin_N PF00134.21 MSTRG.12648.1_3 - 2.4e-40 137.1 1.1 3e-40 136.8 0.3 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 MSTRG.12648.1_3 - 1.5e-19 70.1 0.2 2.9e-19 69.2 0.2 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain Na_Ca_ex PF01699.22 MSTRG.8168.1_1 - 1.2e-19 70.6 2.5 1.2e-19 70.6 2.5 1.8 2 0 0 2 2 2 1 Sodium/calcium exchanger protein Gal-bind_lectin PF00337.20 MSTRG.8881.1_1 - 5.3e-24 84.1 0.0 1.8e-23 82.4 0.0 1.7 1 1 0 1 1 1 1 Galactoside-binding lectin Patched PF02460.16 MSTRG.2885.1_3 - 1.9e-13 49.3 3.9 2.3e-13 49.0 3.9 1.1 1 0 0 1 1 1 1 Patched family PBAN PF05874.9 MSTRG.2885.1_3 - 0.02 14.6 0.0 0.028 14.1 0.0 1.2 1 0 0 1 1 1 0 Pheromone biosynthesis activating neuropeptide (PBAN) COX4_pro PF03626.12 MSTRG.2885.1_3 - 0.23 11.8 3.9 0.55 10.6 3.9 1.7 1 1 0 1 1 1 0 Prokaryotic Cytochrome C oxidase subunit IV 6PF2K PF01591.16 MSTRG.20181.4_3 - 2.7e-76 255.6 1.3 4.6e-76 254.9 1.3 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.20 MSTRG.20181.4_3 - 5e-40 137.2 0.0 6.8e-40 136.7 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.4 MSTRG.20181.4_3 - 0.0072 16.4 0.1 0.014 15.4 0.1 1.4 1 0 0 1 1 1 1 AAA domain BcrAD_BadFG PF01869.18 MSTRG.22135.2_3 - 0.069 12.5 0.4 0.14 11.5 0.4 1.5 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family DIT1_PvcA PF05141.10 MSTRG.22135.2_3 - 1.3 8.3 14.5 0.075 12.4 6.3 2.3 1 1 1 2 2 2 0 Pyoverdine/dityrosine biosynthesis protein DUF725 PF05267.10 MSTRG.22135.2_3 - 5.3 6.9 8.9 0.97 9.3 2.8 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF725) PAF-AH_p_II PF03403.11 MSTRG.25666.1_2 - 4e-151 502.7 0.0 5.1e-151 502.4 0.0 1.1 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.5 MSTRG.25666.1_2 - 2.7e-08 32.9 0.0 1.3e-07 30.6 0.0 1.9 1 1 0 1 1 1 1 Chlorophyllase enzyme Hydrolase_4 PF12146.6 MSTRG.25666.1_2 - 3.3e-06 26.4 0.0 0.042 13.0 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.16 MSTRG.25666.1_2 - 3.3e-05 23.4 0.0 0.00033 20.2 0.0 2.0 1 1 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.19 MSTRG.25666.1_2 - 5.7e-05 22.5 0.0 0.00012 21.5 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.5 MSTRG.25666.1_2 - 6.5e-05 22.6 0.0 0.00022 20.8 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Chlorophyllase PF07224.9 MSTRG.25666.1_2 - 0.00042 19.3 0.0 0.073 11.9 0.0 2.1 2 0 0 2 2 2 2 Chlorophyllase AXE1 PF05448.10 MSTRG.25666.1_2 - 0.0028 16.2 0.0 0.67 8.4 0.0 2.1 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) Abhydrolase_1 PF00561.18 MSTRG.25666.1_2 - 0.0077 15.8 0.0 0.013 15.0 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 MSTRG.25666.1_2 - 0.0088 16.6 0.0 0.044 14.3 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.14 MSTRG.25666.1_2 - 0.012 15.2 0.0 1.5 8.5 0.0 2.4 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Esterase PF00756.18 MSTRG.25666.1_2 - 0.026 14.1 0.0 3.5 7.0 0.0 2.2 2 0 0 2 2 2 0 Putative esterase Abhydrolase_3 PF07859.11 MSTRG.25666.1_2 - 0.14 11.8 0.0 0.3 10.8 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Myb_DNA-bind_5 PF13873.4 MSTRG.13763.1_2 - 1.1e-12 47.7 1.7 2.5e-12 46.5 1.7 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_4 PF13837.4 MSTRG.13763.1_2 - 7.8e-07 29.3 1.3 1.6e-06 28.3 1.3 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 MSTRG.13763.1_2 - 4.1e-06 26.8 0.9 9.6e-06 25.6 0.9 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain MADF_DNA_bdg PF10545.7 MSTRG.13763.1_2 - 0.00012 22.2 0.2 0.00029 20.9 0.2 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-binding PF00249.29 MSTRG.13763.1_2 - 0.0033 17.4 0.2 0.0093 16.0 0.2 1.8 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_3 PF12776.5 MSTRG.13763.1_2 - 0.012 16.3 1.2 0.025 15.3 1.2 1.5 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain DUF3106 PF11304.6 MSTRG.13763.1_2 - 0.068 13.5 0.3 0.068 13.5 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3106) RVT_1 PF00078.25 MSTRG.9734.1_1 - 0.0077 15.6 0.0 0.0082 15.5 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) LRAT PF04970.11 MSTRG.23094.1_3 - 1.8e-12 47.6 0.5 1.1e-09 38.6 0.5 2.3 1 1 0 1 1 1 1 Lecithin retinol acyltransferase NLPC_P60 PF00877.17 MSTRG.23094.1_3 - 0.033 14.1 0.0 0.061 13.2 0.0 1.4 1 0 0 1 1 1 0 NlpC/P60 family RhoGAP PF00620.25 MSTRG.5306.1_2 - 1.9e-48 164.0 0.0 3.6e-48 163.1 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain WW PF00397.24 MSTRG.5306.1_2 - 1.7e-18 66.1 6.5 7.4e-10 38.5 0.9 3.1 3 0 0 3 3 3 2 WW domain PH_9 PF15410.4 MSTRG.5306.1_2 - 1.3e-06 28.7 0.1 6.9e-06 26.3 0.1 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain SH3_1 PF00018.26 MSTRG.5306.1_2 - 1.3e-06 27.8 0.0 2.7e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 SH3 domain PH PF00169.27 MSTRG.5306.1_2 - 4.5e-06 27.0 0.1 1.3e-05 25.5 0.1 1.8 1 0 0 1 1 1 1 PH domain SH3_9 PF14604.4 MSTRG.5306.1_2 - 7.2e-05 22.4 0.0 0.00015 21.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain BORG_CEP PF14957.4 MSTRG.5306.1_2 - 0.33 12.0 4.0 0.21 12.6 0.7 2.3 2 0 0 2 2 2 0 Cdc42 effector BUD22 PF09073.8 MSTRG.5306.1_2 - 3.7 6.6 13.1 0.95 8.6 4.6 2.1 2 0 0 2 2 2 0 BUD22 Xpo1 PF08389.10 MSTRG.18682.2_2 - 2e-21 76.5 17.9 1.1e-19 70.9 0.0 6.8 7 1 0 7 7 7 2 Exportin 1-like protein IBN_N PF03810.17 MSTRG.18682.2_2 - 9.3e-08 31.8 0.4 4e-07 29.7 0.1 2.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain RNA_pol_Rpc4 PF05132.12 MSTRG.21081.1_2 - 1.4e-23 83.9 0.1 2.2e-23 83.2 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase III RPC4 SRP72 PF08492.10 MSTRG.17748.1_1 - 9.8 6.5 9.3 14 6.0 0.5 3.3 3 0 0 3 3 3 0 SRP72 RNA-binding domain FERM_C PF09380.8 MSTRG.25977.1_1 - 1.2e-18 67.1 1.2 1.9e-18 66.5 1.2 1.3 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FA PF08736.9 MSTRG.25977.1_1 - 1.7e-07 31.1 0.5 6.1e-07 29.3 0.5 2.0 1 0 0 1 1 1 1 FERM adjacent (FA) RNA_pol_Rpb8 PF03870.13 MSTRG.10513.1_2 - 3.4e-54 182.7 0.2 4.2e-54 182.4 0.2 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.3 MSTRG.10513.1_2 - 0.00012 22.0 0.1 0.026 14.5 0.0 2.2 2 0 0 2 2 2 2 DNA-directed RNA polymerase, subunit G EF-hand_1 PF00036.30 MSTRG.21927.1_1 - 0.033 13.6 0.0 0.059 12.8 0.0 1.5 1 0 0 1 1 1 0 EF hand Rhomboid PF01694.20 MSTRG.21927.1_1 - 0.2 11.5 0.3 0.2 11.5 0.3 1.9 2 0 0 2 2 2 0 Rhomboid family SMN PF06003.10 MSTRG.21927.1_3 - 1.8 7.6 4.6 0.32 10.1 1.1 1.4 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) Cobalamin_bind PF01122.17 MSTRG.3027.1_1 - 8.7e-106 353.2 7.6 1.1e-105 352.9 7.6 1.1 1 0 0 1 1 1 1 Eukaryotic cobalamin-binding protein DUF4430 PF14478.4 MSTRG.3027.1_1 - 3.4e-09 37.0 0.0 6.1e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4430) Mito_carr PF00153.25 MSTRG.27605.2_1 - 2.6e-59 197.0 1.3 5.1e-21 74.3 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Ras PF00071.20 MSTRG.6960.1_3 - 5.1e-50 169.1 0.0 6.4e-50 168.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.6960.1_3 - 2.6e-18 66.3 0.0 3.8e-18 65.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.6960.1_3 - 2.3e-06 27.0 0.0 3.8e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRR1 PF07985.10 MSTRG.5656.1_3 - 4.6e-17 61.7 0.4 9.7e-17 60.7 0.4 1.6 1 0 0 1 1 1 1 SRR1 CH PF00307.29 MSTRG.7864.2_2 - 9.7e-46 154.3 0.2 4e-22 78.3 0.3 3.2 2 0 0 2 2 2 2 Calponin homology (CH) domain Spectrin PF00435.19 MSTRG.7864.2_2 - 1.6e-08 34.8 46.6 0.0027 18.0 1.2 8.3 6 3 1 7 7 7 5 Spectrin repeat CAMSAP_CH PF11971.6 MSTRG.7864.2_2 - 8.9e-08 31.7 0.0 0.00024 20.7 0.0 3.2 2 0 0 2 2 2 2 CAMSAP CH domain DUF4132 PF13569.4 MSTRG.7864.2_2 - 0.079 12.6 2.1 0.69 9.6 0.7 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4132) AAA_9 PF12781.5 MSTRG.19122.1_1 - 7.3e-10 38.2 1.5 7.3e-10 38.2 1.5 1.6 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 Dynein_heavy PF03028.13 MSTRG.19122.1_1 - 1.3e-06 26.8 0.0 2.3e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor SurA_N_3 PF13624.4 MSTRG.19122.1_1 - 0.095 12.3 0.9 1.8 8.2 0.1 2.1 2 0 0 2 2 2 0 SurA N-terminal domain Trans_reg_C PF00486.26 MSTRG.19122.1_1 - 0.098 12.6 0.2 0.26 11.2 0.2 1.8 1 1 0 1 1 1 0 Transcriptional regulatory protein, C terminal Collagen PF01391.16 MSTRG.544.1_2 - 1.2e-10 40.9 37.1 6.8e-09 35.2 25.1 2.1 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) PD-C2-AF1 PF09310.8 MSTRG.27282.1_1 - 0.0015 17.9 1.4 0.0022 17.3 1.4 1.1 1 0 0 1 1 1 1 POU domain, class 2, associating factor 1 zinc-ribbons_6 PF07191.10 MSTRG.18717.2_2 - 0.25 11.2 11.5 0.65 9.9 0.8 2.6 1 1 1 2 2 2 0 zinc-ribbons zf-ribbon_3 PF13248.4 MSTRG.18717.2_2 - 8.1 5.9 11.2 0.11 11.9 0.7 2.4 2 0 0 2 2 2 0 zinc-ribbon domain NADH_B2 PF14813.4 MSTRG.9588.1_1 - 0.019 14.6 0.2 0.019 14.6 0.2 1.7 2 0 0 2 2 2 0 NADH dehydrogenase 1 beta subcomplex subunit 2 Ferric_reduct PF01794.17 MSTRG.9588.1_3 - 1.8e-11 44.1 1.5 1.8e-11 44.1 1.5 2.3 1 1 1 2 2 2 2 Ferric reductase like transmembrane component KSR1-SAM PF13543.4 MSTRG.27313.4_1 - 3.4e-05 23.8 0.1 5.4e-05 23.2 0.1 1.3 1 0 0 1 1 1 1 SAM like domain present in kinase suppressor RAS 1 C1_1 PF00130.20 MSTRG.27313.4_1 - 0.00052 19.7 12.8 0.00052 19.7 12.8 1.7 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Peptidase_M1 PF01433.18 MSTRG.12350.2_3 - 8.8e-131 436.6 0.1 1.3e-130 436.1 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.6 MSTRG.12350.2_3 - 3.5e-85 286.2 4.4 1.2e-84 284.4 3.8 2.0 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Med16 PF11635.6 MSTRG.24378.1_3 - 5e-66 223.0 0.0 7.8e-66 222.4 0.0 1.3 1 0 0 1 1 1 1 Mediator complex subunit 16 Occludin_ELL PF07303.11 MSTRG.10384.1_1 - 8.3e-28 96.9 6.3 1.5e-27 96.1 6.3 1.4 1 0 0 1 1 1 1 Occludin homology domain Sec34 PF04136.13 MSTRG.10384.1_1 - 0.033 14.0 1.1 0.052 13.3 0.3 1.7 2 0 0 2 2 2 0 Sec34-like family DUF2433 PF10360.7 MSTRG.10384.1_1 - 0.049 13.6 0.2 0.088 12.8 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2433) FHIPEP PF00771.18 MSTRG.10384.1_1 - 0.098 11.0 0.1 0.14 10.4 0.1 1.2 1 0 0 1 1 1 0 FHIPEP family VWD PF00094.23 MSTRG.11951.10_1 - 4.9e-154 507.7 20.2 1.7e-38 132.2 0.0 4.3 4 0 0 4 4 4 4 von Willebrand factor type D domain C8 PF08742.9 MSTRG.11951.10_1 - 1.2e-78 259.3 34.5 9.7e-24 83.4 1.1 8.3 9 0 0 9 9 9 4 C8 domain TILa PF12714.5 MSTRG.11951.10_1 - 5.1e-49 163.9 86.5 5.9e-15 54.8 11.8 11.1 10 1 0 10 10 10 5 TILa domain TIL PF01826.15 MSTRG.11951.10_1 - 4.1e-39 132.5 112.3 9.2e-13 48.1 15.3 14.6 15 0 0 15 15 15 6 Trypsin Inhibitor like cysteine rich domain VWC PF00093.16 MSTRG.11951.10_1 - 2.5e-05 24.4 25.8 0.00019 21.6 9.4 12.8 11 5 1 12 12 12 5 von Willebrand factor type C domain Myosin_N PF02736.17 MSTRG.11951.10_1 - 0.018 14.7 1.5 0.19 11.4 0.5 2.5 2 0 0 2 2 2 0 Myosin N-terminal SH3-like domain Pkinase PF00069.23 MSTRG.13846.1_1 - 2.1e-64 217.3 0.0 3.5e-64 216.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.13846.1_1 - 4.1e-49 167.1 0.0 7.3e-49 166.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.13846.1_1 - 0.00034 19.9 0.0 0.00056 19.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 MSTRG.13846.1_1 - 0.0011 18.2 0.2 0.0022 17.3 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 MSTRG.13846.1_1 - 0.035 13.9 0.3 1.9 8.2 0.1 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family AKAP95 PF04988.10 MSTRG.27700.3_2 - 9.5e-67 224.2 9.5 1.9e-66 223.2 9.5 1.5 1 0 0 1 1 1 1 A-kinase anchoring protein 95 (AKAP95) zf-H2C2_5 PF13909.4 MSTRG.27700.3_2 - 0.05 13.2 0.6 0.16 11.6 0.6 1.9 1 0 0 1 1 1 0 C2H2-type zinc-finger domain Actin_micro PF17003.3 MSTRG.27700.3_2 - 0.05 12.6 12.1 64 2.4 12.1 2.2 1 1 0 1 1 1 0 Putative actin-like family BUD22 PF09073.8 MSTRG.27700.3_2 - 3.8 6.6 34.6 0.34 10.1 19.9 2.1 2 0 0 2 2 2 0 BUD22 ubiquitin PF00240.21 MSTRG.5481.8_1 - 6.3e-07 28.9 0.0 1.1e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Got1 PF04178.10 MSTRG.23981.2_2 - 1e-32 112.8 18.0 1.9e-32 111.9 18.0 1.4 1 0 0 1 1 1 1 Got1/Sft2-like family TMEM43 PF07787.10 MSTRG.23981.2_2 - 6 6.0 7.2 21 4.2 7.2 1.8 1 1 0 1 1 1 0 Transmembrane protein 43 Hist_deacetyl PF00850.17 MSTRG.21628.3_3 - 2.1e-85 286.8 0.0 6.6e-85 285.1 0.0 1.8 2 0 0 2 2 2 1 Histone deacetylase domain TruD PF01142.16 MSTRG.21628.3_3 - 8.6e-74 248.7 0.0 1.1e-67 228.5 0.0 2.3 2 0 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) zf-H2C2_2 PF13465.4 MSTRG.22886.1_3 - 1.8e-13 50.1 29.7 2.7e-08 33.7 3.0 6.0 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.22886.1_3 - 4.6e-08 33.0 55.3 2.6e-05 24.3 0.4 7.6 9 0 0 9 9 9 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.22886.1_3 - 2.8e-07 30.6 42.0 0.0017 18.9 0.4 7.8 7 0 0 7 7 7 3 C2H2-type zinc finger zf-H2C2_5 PF13909.4 MSTRG.22886.1_3 - 1.4e-05 24.6 3.2 0.0018 17.9 0.7 5.4 5 0 0 5 5 5 2 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.3 MSTRG.22886.1_3 - 0.0067 16.0 0.1 0.0067 16.0 0.1 4.4 4 0 0 4 4 4 1 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 MSTRG.22886.1_3 - 1.3 8.9 32.9 0.1 12.4 6.2 5.5 5 0 0 5 5 5 0 C2H2-type zinc finger HeLo PF14479.4 MSTRG.10659.1_2 - 0.68 9.6 5.8 1.1 8.9 5.8 1.3 1 0 0 1 1 1 0 Prion-inhibition and propagation MCC-bdg_PDZ PF10506.7 MSTRG.10659.1_3 - 1.4e-16 60.1 3.9 2.8e-16 59.2 3.9 1.5 1 0 0 1 1 1 1 PDZ domain of MCC-2 bdg protein for Usher syndrome CENP-F_leu_zip PF10473.7 MSTRG.10659.1_3 - 0.0076 16.1 0.3 0.023 14.6 0.3 1.8 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IncA PF04156.12 MSTRG.10659.1_3 - 0.11 12.2 6.6 0.096 12.3 1.5 2.3 2 0 0 2 2 2 0 IncA protein Pkinase_Tyr PF07714.15 MSTRG.20690.1_3 - 6.2e-99 330.4 0.0 1.2e-98 329.4 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.20690.1_3 - 1.5e-41 142.3 0.0 7.2e-27 94.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.4 MSTRG.20690.1_3 - 4.4e-23 81.6 0.2 6.5e-07 29.7 0.2 5.6 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.14 MSTRG.20690.1_3 - 1.2e-15 57.2 0.0 1.2e-07 31.5 0.0 5.1 5 0 0 5 5 5 2 Immunoglobulin I-set domain ig PF00047.23 MSTRG.20690.1_3 - 1.2e-14 54.0 0.4 7.9e-05 22.6 0.1 5.6 5 0 0 5 5 5 3 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.20690.1_3 - 6.2e-14 52.0 0.6 0.00077 19.6 0.2 5.2 5 0 0 5 5 5 4 Immunoglobulin domain V-set PF07686.15 MSTRG.20690.1_3 - 1.1e-09 38.2 0.1 0.72 9.9 0.0 5.7 4 1 0 4 4 4 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 MSTRG.20690.1_3 - 0.03 14.2 0.9 8.3 6.4 0.1 3.1 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain SET PF00856.26 MSTRG.891.1_3 - 3.1e-11 43.8 0.1 1e-09 38.9 0.1 2.5 1 1 0 1 1 1 1 SET domain TPR_2 PF07719.15 MSTRG.891.1_3 - 2e-05 24.2 1.5 0.16 12.0 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat zf-MYND PF01753.16 MSTRG.891.1_3 - 3.8e-05 23.5 14.2 3.8e-05 23.5 14.2 3.0 2 1 0 2 2 2 1 MYND finger TPR_1 PF00515.26 MSTRG.891.1_3 - 0.0075 15.9 0.6 0.38 10.5 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.891.1_3 - 0.021 14.4 0.0 0.067 12.8 0.0 1.8 2 0 0 2 2 2 0 TPR repeat Amb_V_allergen PF03913.11 MSTRG.4797.1_1 - 0.57 10.0 4.5 1.4 8.8 4.5 1.6 1 0 0 1 1 1 0 Amb V Allergen Phosphodiest PF01663.20 MSTRG.4797.1_2 - 5.9e-77 259.5 1.5 7.2e-77 259.2 1.5 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.21 MSTRG.4797.1_2 - 2.5e-07 30.3 0.2 0.0013 18.0 0.0 2.3 2 0 0 2 2 2 2 Sulfatase Metalloenzyme PF01676.16 MSTRG.4797.1_2 - 1.5e-06 27.6 0.0 2.8e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Metalloenzyme superfamily MAP17 PF15807.3 MSTRG.4797.1_2 - 0.00026 21.1 0.0 0.00049 20.2 0.0 1.4 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 FixQ PF05545.9 MSTRG.4797.1_2 - 0.12 12.3 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ zf-H2C2_2 PF13465.4 MSTRG.21808.1_3 - 9.9e-62 202.7 137.2 4.6e-08 33.0 0.3 21.0 19 2 1 20 20 20 13 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.21808.1_3 - 4e-57 187.5 153.4 9.6e-06 25.6 0.2 21.6 21 0 0 21 21 21 18 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.21808.1_3 - 9e-49 159.8 147.4 0.003 18.1 0.3 21.5 21 0 0 21 21 21 21 C2H2-type zinc finger TINF2_N PF14973.4 MSTRG.21808.1_3 - 1.6e-46 158.2 0.1 3.9e-46 156.9 0.1 1.7 1 0 0 1 1 1 1 TERF1-interacting nuclear factor 2 N-terminus zf-C2H2_jaz PF12171.6 MSTRG.21808.1_3 - 2.7e-23 81.6 87.6 0.038 14.2 0.0 19.2 19 0 0 19 19 19 12 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.21808.1_3 - 1.3e-09 37.9 111.3 0.42 10.9 0.6 18.4 19 0 0 19 19 19 10 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 MSTRG.21808.1_3 - 4e-07 29.7 134.7 0.0093 15.8 3.9 20.1 21 0 0 21 21 21 8 C2H2-type zinc finger Rad50_zn_hook PF04423.12 MSTRG.21808.1_3 - 0.0029 17.3 11.9 1.5 8.6 0.1 4.7 4 0 0 4 4 4 3 Rad50 zinc hook motif zf-Di19 PF05605.10 MSTRG.21808.1_3 - 0.022 14.9 1.2 0.022 14.9 1.2 11.5 9 3 2 12 12 12 0 Drought induced 19 protein (Di19), zinc-binding HAT_KAT11 PF08214.9 MSTRG.24116.6_1 - 8.1e-67 225.8 0.5 8.1e-67 225.8 0.5 2.4 2 0 0 2 2 2 1 Histone acetylation protein KIX PF02172.14 MSTRG.24116.6_1 - 7.9e-39 131.7 0.3 2.2e-38 130.3 0.3 1.8 1 0 0 1 1 1 1 KIX domain Creb_binding PF09030.8 MSTRG.24116.6_1 - 1.1e-34 119.2 28.1 1.1e-34 119.2 28.1 11.1 3 3 7 11 11 11 1 Creb binding DUF902 PF06001.11 MSTRG.24116.6_1 - 9.5e-20 70.7 9.4 9.5e-20 70.7 9.4 2.4 2 0 0 2 2 2 1 Domain of Unknown Function (DUF902) Bromodomain PF00439.23 MSTRG.24116.6_1 - 1.1e-16 60.5 0.1 2.9e-16 59.1 0.1 1.7 1 0 0 1 1 1 1 Bromodomain ZZ PF00569.15 MSTRG.24116.6_1 - 5.7e-16 57.9 13.5 5.7e-16 57.9 13.5 3.0 3 0 0 3 3 3 1 Zinc finger, ZZ type zf-TAZ PF02135.14 MSTRG.24116.6_1 - 4.8e-12 46.0 25.9 4.8e-12 46.0 25.9 3.0 2 0 0 2 2 2 1 TAZ zinc finger Npa1 PF11707.6 MSTRG.24116.6_1 - 0.0034 16.7 0.0 0.0061 15.9 0.0 1.3 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal ITI_HC_C PF06668.10 MSTRG.24260.1_2 - 1.7e-32 112.5 0.0 1.9e-32 112.3 0.0 1.0 1 0 0 1 1 1 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus Ribosomal_L5 PF00281.17 MSTRG.7876.2_2 - 2.1e-20 72.7 0.0 1.4e-19 70.0 0.0 2.1 2 0 0 2 2 2 1 Ribosomal protein L5 Ribosomal_L5_C PF00673.19 MSTRG.7876.2_2 - 1.4e-19 69.9 0.0 2.2e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 ribosomal L5P family C-terminus SNN_cytoplasm PF09051.8 MSTRG.7876.2_3 - 0.057 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Stannin cytoplasmic Cyt-b5 PF00173.26 MSTRG.1260.1_3 - 3.1e-11 43.1 0.0 5.4e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain ERK-JNK_inhib PF15002.4 MSTRG.7969.4_3 - 6.6e-73 244.5 0.1 8.4e-73 244.1 0.1 1.1 1 0 0 1 1 1 1 ERK and JNK pathways, inhibitor Lamp PF01299.15 MSTRG.16060.1_2 - 1.4e-117 392.6 14.0 2.7e-113 378.5 10.7 2.2 1 1 1 2 2 2 2 Lysosome-associated membrane glycoprotein (Lamp) ATP-synt_S1 PF05827.10 MSTRG.16060.1_2 - 4.2e-06 26.5 0.7 0.00098 18.8 0.1 2.5 2 0 0 2 2 2 2 Vacuolar ATP synthase subunit S1 (ATP6S1) DEC-1_N PF04625.11 MSTRG.16060.1_2 - 0.055 12.4 0.3 0.089 11.7 0.3 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region SAM_2 PF07647.15 MSTRG.7200.4_1 - 5.8e-05 23.0 0.0 0.00017 21.5 0.0 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) RhoGEF PF00621.18 MSTRG.26126.5_2 - 4.1e-44 150.8 0.8 7.7e-44 150.0 0.8 1.5 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 MSTRG.26126.5_2 - 0.0011 19.3 0.3 0.0044 17.4 0.1 2.1 2 0 0 2 2 2 1 PH domain Spore_Cse60 PF10957.6 MSTRG.26126.5_2 - 0.12 12.2 0.1 0.43 10.5 0.1 2.0 1 0 0 1 1 1 0 Sporulation protein Cse60 DUF423 PF04241.13 MSTRG.29322.1_2 - 4.2e-10 39.6 0.5 7.4e-10 38.8 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF423) Nop14 PF04147.10 MSTRG.27468.1_2 - 0.024 12.8 11.9 0.036 12.2 11.9 1.2 1 0 0 1 1 1 0 Nop14-like family bZIP_1 PF00170.19 MSTRG.27468.1_2 - 0.1 12.6 8.7 0.23 11.4 8.7 1.5 1 0 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.13 MSTRG.27468.1_2 - 0.42 10.6 7.1 1.2 9.1 7.1 1.8 1 0 0 1 1 1 0 Basic region leucine zipper CDC45 PF02724.12 MSTRG.27468.1_2 - 3 5.9 11.5 2.5 6.2 10.0 1.6 2 0 0 2 2 2 0 CDC45-like protein Sporozoite_P67 PF05642.9 MSTRG.27468.1_2 - 3.1 5.6 7.0 4.7 5.0 7.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Glyco_hydro_15 PF00723.19 MSTRG.17473.1_1 - 0.0051 15.5 0.0 0.0069 15.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Glyco_hydro_15 PF00723.19 MSTRG.17473.1_2 - 3.3e-44 151.3 0.0 4.5e-44 150.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 PseudoU_synth_2 PF00849.20 MSTRG.4030.2_1 - 8.2e-26 90.9 0.4 1.6e-25 90.0 0.0 1.6 2 0 0 2 2 2 1 RNA pseudouridylate synthase Mito_carr PF00153.25 MSTRG.4030.2_1 - 0.00013 21.7 0.0 0.00024 20.8 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial carrier protein CPP1-like PF11833.6 MSTRG.4030.2_1 - 0.15 11.5 0.1 0.25 10.8 0.1 1.3 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF3824 PF12868.5 MSTRG.4030.2_1 - 0.83 10.2 4.5 1.9 9.0 4.5 1.6 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) DUF2956 PF11169.6 MSTRG.4030.2_1 - 3.1 7.9 6.0 6.5 6.9 6.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) IL10 PF00726.15 MSTRG.13879.1_1 - 3.1e-28 98.3 0.3 4.2e-28 97.8 0.3 1.1 1 0 0 1 1 1 1 Interleukin 10 IL22 PF14565.4 MSTRG.13879.1_1 - 1.5e-07 31.7 0.1 2.3e-07 31.0 0.1 1.2 1 0 0 1 1 1 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor Clusterin PF01093.15 MSTRG.7848.2_1 - 2.1e-70 237.8 0.0 2.8e-70 237.4 0.0 1.1 1 0 0 1 1 1 1 Clusterin DIL PF01843.17 MSTRG.8294.3_3 - 9.9e-32 109.2 5.0 9.9e-32 109.2 5.0 2.1 2 0 0 2 2 2 1 DIL domain PDZ PF00595.22 MSTRG.8294.3_3 - 5.4e-17 61.8 0.5 1.4e-16 60.5 0.5 1.7 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.8294.3_3 - 4.5e-05 23.5 0.1 0.00013 22.1 0.1 1.7 1 0 0 1 1 1 1 PDZ domain F5_F8_type_C PF00754.23 MSTRG.17477.1_3 - 1.9e-28 99.0 0.2 2.7e-28 98.5 0.2 1.2 1 0 0 1 1 1 1 F5/8 type C domain RNA_GG_bind PF10258.7 MSTRG.15198.2_2 - 3.5e-30 103.7 0.1 8.9e-30 102.4 0.1 1.7 1 0 0 1 1 1 1 PHAX RNA-binding domain TruD PF01142.16 MSTRG.15198.2_3 - 1.4e-43 149.2 0.0 1.4e-40 139.3 0.0 2.1 2 0 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) Recep_L_domain PF01030.22 MSTRG.4665.1_2 - 1.4e-55 186.1 3.2 1.9e-27 95.5 0.2 2.4 2 0 0 2 2 2 2 Receptor L domain Furin-like PF00757.18 MSTRG.4665.1_2 - 6.5e-39 133.1 43.0 1.1e-38 132.3 43.0 1.4 1 0 0 1 1 1 1 Furin-like cysteine rich region fn3 PF00041.19 MSTRG.4665.1_2 - 1.9e-13 50.4 1.0 6.7e-05 23.0 0.1 3.5 3 0 0 3 3 3 3 Fibronectin type III domain PMP22_Claudin PF00822.18 MSTRG.6525.1_2 - 0.098 12.4 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family HECT PF00632.23 MSTRG.3238.1_3 - 2.1e-98 329.4 0.2 2.8e-98 329.0 0.2 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.24 MSTRG.3238.1_3 - 9.2e-45 150.1 18.5 5.4e-12 45.3 1.8 4.6 4 0 0 4 4 4 4 WW domain C2 PF00168.28 MSTRG.3238.1_3 - 8.1e-14 51.6 0.3 1.6e-13 50.7 0.3 1.4 1 0 0 1 1 1 1 C2 domain MBD PF01429.17 MSTRG.3238.1_3 - 9.4 5.9 8.2 24 4.6 0.3 4.1 5 0 0 5 5 5 0 Methyl-CpG binding domain LYRIC PF15686.3 MSTRG.24615.3_3 - 9e-127 423.9 23.1 9e-127 423.9 23.1 2.1 2 0 0 2 2 2 1 Lysine-rich CEACAM1 co-isolated protein family MAP17 PF15807.3 MSTRG.24615.3_3 - 0.015 15.4 0.1 0.015 15.4 0.1 3.6 3 0 0 3 3 3 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 zf-DHHC PF01529.18 MSTRG.16014.1_1 - 0.033 14.1 0.0 0.051 13.5 0.0 1.3 1 0 0 1 1 1 0 DHHC palmitoyltransferase Rabaptin PF03528.13 MSTRG.921.1_3 - 8.9e-241 799.6 37.7 8.9e-241 799.6 37.7 2.4 2 1 0 2 2 2 1 Rabaptin Rab5-bind PF09311.9 MSTRG.921.1_3 - 1.6e-87 293.7 31.4 1.6e-87 293.7 31.4 4.4 2 1 3 5 5 5 1 Rabaptin-like protein Cep57_MT_bd PF06657.11 MSTRG.921.1_3 - 0.011 16.1 2.1 0.011 16.1 2.1 7.4 6 2 2 8 8 8 0 Centrosome microtubule-binding domain of Cep57 TruB_C_2 PF16198.3 MSTRG.921.1_3 - 3 7.9 6.8 0.86 9.7 0.7 3.4 3 0 0 3 3 3 0 tRNA pseudouridylate synthase B C-terminal domain Cyt-b5 PF00173.26 MSTRG.21991.1_2 - 1.2e-20 73.2 0.1 2e-20 72.6 0.1 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain CALCOCO1 PF07888.9 MSTRG.18158.2_3 - 1.6e-31 109.4 31.3 1.2e-30 106.6 31.4 2.4 1 1 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like GAS PF13851.4 MSTRG.18158.2_3 - 1.7 7.8 25.8 0.059 12.6 3.4 3.1 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding DUF641 PF04859.10 MSTRG.18158.2_3 - 2.1 8.6 19.9 0.45 10.7 0.1 3.2 3 0 0 3 3 3 0 Plant protein of unknown function (DUF641) dsrm PF00035.24 MSTRG.16614.1_2 - 3.9e-19 69.0 3.2 4.5e-12 46.3 0.0 3.7 3 1 0 3 3 3 2 Double-stranded RNA binding motif WW PF00397.24 MSTRG.16614.1_2 - 0.00022 20.9 0.0 0.00045 20.0 0.0 1.6 1 0 0 1 1 1 1 WW domain ABC_membrane PF00664.21 MSTRG.16525.1_2 - 3e-46 158.2 7.7 4.2e-46 157.7 7.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.25 MSTRG.16525.1_2 - 8.7e-35 120.1 0.0 1.9e-34 119.0 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.17 MSTRG.16525.1_2 - 8e-10 38.4 0.9 1.5e-06 27.7 0.0 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 MSTRG.16525.1_2 - 2.6e-06 27.8 0.0 6.1e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 MSTRG.16525.1_2 - 1.2e-05 25.5 0.1 8.4e-05 22.7 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.4 MSTRG.16525.1_2 - 0.00034 20.1 0.0 0.00075 19.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_ATPase PF09818.7 MSTRG.16525.1_2 - 0.00056 18.7 0.1 0.0017 17.1 0.0 1.8 2 0 0 2 2 2 1 Predicted ATPase of the ABC class DUF258 PF03193.14 MSTRG.16525.1_2 - 0.002 17.9 0.0 0.0045 16.8 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_25 PF13481.4 MSTRG.16525.1_2 - 0.0093 15.4 0.2 0.86 9.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.4 MSTRG.16525.1_2 - 0.012 15.7 0.5 0.11 12.6 0.5 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.4 MSTRG.16525.1_2 - 0.024 14.2 1.3 0.17 11.5 0.2 2.5 2 1 0 2 2 2 0 AAA domain AAA PF00004.27 MSTRG.16525.1_2 - 0.028 14.7 1.0 0.61 10.4 0.4 2.6 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.4 MSTRG.16525.1_2 - 0.051 13.0 0.1 0.1 12.0 0.0 1.5 2 0 0 2 2 2 0 AAA ATPase domain DEAD PF00270.27 MSTRG.16525.1_2 - 0.054 13.1 0.1 0.16 11.6 0.1 1.7 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_5 PF07728.12 MSTRG.16525.1_2 - 0.11 12.4 0.1 4 7.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) FAD_binding_4 PF01565.21 MSTRG.23814.1_2 - 5.2e-13 48.8 0.0 8.2e-13 48.1 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Myosin_tail_1 PF01576.17 MSTRG.7995.1_1 - 0 1653.4 302.3 0 1653.1 302.3 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.19 MSTRG.7995.1_1 - 0 1012.8 1.5 0 1012.8 1.5 2.9 3 0 0 3 3 3 1 Myosin head (motor domain) Myosin_N PF02736.17 MSTRG.7995.1_1 - 4.2e-11 42.4 1.1 9.1e-11 41.3 1.1 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain IQ PF00612.25 MSTRG.7995.1_1 - 0.0001 21.7 0.4 0.00031 20.2 0.4 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif ADIP PF11559.6 MSTRG.7995.1_1 - 0.00028 20.9 19.3 0.00028 20.9 19.3 14.3 1 1 13 15 15 15 4 Afadin- and alpha -actinin-Binding TPR_MLP1_2 PF07926.10 MSTRG.7995.1_1 - 0.00044 20.2 11.3 0.00044 20.2 11.3 11.7 2 2 9 11 11 11 3 TPR/MLP1/MLP2-like protein AAA_22 PF13401.4 MSTRG.7995.1_1 - 0.058 13.5 0.0 0.058 13.5 0.0 5.3 5 1 0 5 5 5 0 AAA domain Reo_sigmaC PF04582.10 MSTRG.7995.1_1 - 0.75 9.0 66.9 0.59 9.3 3.0 8.9 2 1 5 9 9 9 0 Reovirus sigma C capsid protein Acetyltransf_1 PF00583.23 MSTRG.7995.1_3 - 8e-12 45.3 0.0 1.3e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.5 MSTRG.7995.1_3 - 1.1e-06 28.5 0.0 1.8e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.5 MSTRG.7995.1_3 - 0.0042 17.4 0.0 0.0075 16.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF4113 PF13438.4 MSTRG.28009.1_1 - 0.051 13.5 0.5 0.051 13.5 0.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4113) SH3_1 PF00018.26 MSTRG.13197.2_1 - 5.7e-20 70.5 13.9 7.1e-07 28.6 1.0 4.1 4 0 0 4 4 4 3 SH3 domain SH3_2 PF07653.15 MSTRG.13197.2_1 - 1.3e-15 56.7 2.9 2e-05 24.0 0.0 3.5 3 0 0 3 3 3 3 Variant SH3 domain SH3_9 PF14604.4 MSTRG.13197.2_1 - 5.5e-14 51.6 7.6 3.9e-05 23.3 0.3 3.4 3 0 0 3 3 3 3 Variant SH3 domain SH3_3 PF08239.9 MSTRG.13197.2_1 - 2.5e-05 24.3 9.5 0.11 12.6 1.3 3.5 3 0 0 3 3 3 3 Bacterial SH3 domain DUF1604 PF07713.11 MSTRG.13197.2_1 - 0.067 12.9 0.6 19 5.0 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1604) PolyA_pol PF01743.18 MSTRG.13065.3_3 - 2e-34 118.6 0.8 3.4e-34 117.8 0.8 1.4 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.5 MSTRG.13065.3_3 - 5.3e-12 45.2 0.1 1.7e-11 43.6 0.1 1.8 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A LAMTOR PF15454.4 MSTRG.17068.1_3 - 6.3e-18 65.0 0.0 1.2e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator V-set PF07686.15 MSTRG.8523.1_1 - 5.6e-14 52.1 0.0 8e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 MSTRG.8523.1_1 - 1.8e-05 24.6 0.0 3.2e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.8523.1_1 - 2.4e-05 24.7 0.0 4.2e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 MSTRG.8523.1_1 - 3.2e-05 23.8 0.0 6.2e-05 22.9 0.0 1.4 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.8523.1_1 - 0.00082 19.5 0.0 0.0079 16.4 0.0 2.0 1 1 0 1 1 1 1 Immunoglobulin domain Ribonuc_P_40 PF08584.9 MSTRG.29008.1_3 - 1.8e-27 96.2 0.0 2.1e-27 96.0 0.0 1.0 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit EVC2_like PF12297.6 MSTRG.13767.1_2 - 2.5e-143 477.7 19.5 2.5e-143 477.7 19.5 2.9 3 0 0 3 3 3 2 Ellis van Creveld protein 2 like protein AbiEi_3 PF11459.6 MSTRG.13767.1_2 - 0.0082 15.7 3.1 0.0082 15.7 3.1 2.0 2 0 0 2 2 2 1 Transcriptional regulator, AbiEi antitoxin, Type IV TA system MyTH4 PF00784.15 MSTRG.16361.6_3 - 6e-21 74.8 0.0 8.7e-21 74.3 0.0 1.4 1 1 0 1 1 1 1 MyTH4 domain MSL1_dimer PF16801.3 MSTRG.16361.6_3 - 0.054 13.1 0.2 0.37 10.5 0.1 2.2 2 0 0 2 2 2 0 Dimerisation domain of Male-specific-Lethal 1 Sec1 PF00995.21 MSTRG.16662.2_2 - 1.2e-120 404.3 0.5 1.3e-120 404.1 0.5 1.0 1 0 0 1 1 1 1 Sec1 family Arrestin_C PF02752.20 MSTRG.5718.3_3 - 0.00026 21.2 0.2 0.00046 20.4 0.2 1.4 1 1 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain 7tm_2 PF00002.22 MSTRG.10537.1_1 - 7.9e-07 28.5 1.4 7.9e-07 28.5 1.4 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) Ran_BP1 PF00638.16 MSTRG.24851.1_3 - 1.1e-14 54.6 0.0 1.8e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 RanBP1 domain ACOX PF01756.17 MSTRG.24851.1_3 - 0.035 13.6 0.1 0.057 12.9 0.1 1.3 1 0 0 1 1 1 0 Acyl-CoA oxidase zf-RING_2 PF13639.4 MSTRG.967.1_1 - 4.9e-10 39.4 12.8 4.9e-10 39.4 12.8 2.5 2 0 0 2 2 1 1 Ring finger domain zf-rbx1 PF12678.5 MSTRG.967.1_1 - 5.5e-08 32.9 10.0 2.2e-07 30.9 10.0 2.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.23 MSTRG.967.1_1 - 3.7e-06 26.6 12.8 1.2e-05 25.0 12.8 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 MSTRG.967.1_1 - 5.4e-06 26.0 12.7 5.4e-06 26.0 12.7 2.1 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.967.1_1 - 7.4e-06 25.7 8.6 2.4e-05 24.1 8.6 2.0 1 0 0 1 1 1 1 RING-type zinc-finger TPR_2 PF07719.15 MSTRG.967.1_1 - 3.9e-05 23.3 10.6 0.86 9.7 0.1 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.967.1_1 - 6.9e-05 22.9 2.9 0.3 11.3 0.1 3.4 2 0 0 2 2 2 2 Tetratricopeptide repeat zf-C3HC4_3 PF13920.4 MSTRG.967.1_1 - 7.2e-05 22.4 8.7 0.00023 20.8 8.7 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 MSTRG.967.1_1 - 0.00017 21.5 2.6 0.00051 19.9 2.6 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.3 MSTRG.967.1_1 - 0.00028 20.4 11.9 0.00076 19.0 11.9 1.7 1 0 0 1 1 1 1 RING-like zinc finger TPR_1 PF00515.26 MSTRG.967.1_1 - 0.00033 20.2 2.3 1 9.2 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.967.1_1 - 0.0013 19.2 2.3 0.16 12.6 0.1 3.8 2 1 1 3 3 3 1 Tetratricopeptide repeat zf-RING_5 PF14634.4 MSTRG.967.1_1 - 0.0029 17.4 10.4 0.0029 17.4 10.4 2.3 2 0 0 2 2 1 1 zinc-RING finger domain DUF604 PF04646.10 MSTRG.967.1_1 - 0.031 13.5 0.0 0.1 11.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF604 TPR_11 PF13414.4 MSTRG.967.1_1 - 0.053 13.1 2.0 0.32 10.6 0.0 3.1 4 0 0 4 4 3 0 TPR repeat Zn_ribbon_17 PF17120.3 MSTRG.967.1_1 - 0.067 12.7 7.9 0.21 11.1 7.9 1.9 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.4 MSTRG.967.1_1 - 1 9.1 10.0 2.2 8.1 10.0 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-HC5HC2H PF13771.4 MSTRG.967.1_1 - 5.9 7.1 10.5 9 6.5 5.2 2.7 2 0 0 2 2 2 0 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.4 MSTRG.967.1_1 - 6.4 6.9 7.7 7.3 6.7 3.1 2.5 2 0 0 2 2 2 0 PHD-zinc-finger like domain zf-C3HC4_4 PF15227.4 MSTRG.967.1_1 - 6.8 6.8 10.2 18 5.4 10.2 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING APP_N PF02177.14 MSTRG.27167.6_3 - 1.3e-42 144.1 0.8 3.7e-42 142.6 0.8 1.8 1 0 0 1 1 1 1 Amyloid A4 N-terminal heparin-binding APP_Cu_bd PF12924.5 MSTRG.27167.6_3 - 4.2e-25 88.1 6.7 4.2e-25 88.1 6.7 2.5 2 0 0 2 2 2 1 Copper-binding of amyloid precursor, CuBD Kunitz_BPTI PF00014.21 MSTRG.27167.6_3 - 8.8e-20 70.6 2.6 8.8e-20 70.6 2.6 2.0 2 0 0 2 2 2 1 Kunitz/Bovine pancreatic trypsin inhibitor domain APP_E2 PF12925.5 MSTRG.27167.6_3 - 3.9e-18 65.7 2.4 3.9e-18 65.7 2.4 1.8 2 0 0 2 2 2 1 E2 domain of amyloid precursor protein SDA1 PF05285.10 MSTRG.27167.6_3 - 5.1 6.3 25.5 0.16 11.3 19.0 1.6 2 0 0 2 2 2 0 SDA1 Cofilin_ADF PF00241.18 MSTRG.8951.3_2 - 8.6e-33 113.1 0.2 1.1e-32 112.7 0.2 1.2 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Chorein_N PF12624.5 MSTRG.4707.3_1 - 1.1e-17 64.1 0.0 1.8e-17 63.4 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 Sema PF01403.17 MSTRG.3146.1_1 - 8.6e-27 93.8 0.0 4e-26 91.6 0.0 2.0 1 1 1 2 2 2 1 Sema domain V-set PF07686.15 MSTRG.3146.1_1 - 1e-06 28.8 0.1 0.00014 21.9 0.1 2.7 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.4 MSTRG.3146.1_1 - 3.4e-06 27.2 0.0 1.1e-05 25.5 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.3146.1_1 - 1.8e-05 25.1 0.0 4.3e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 MSTRG.3146.1_1 - 0.001 19.1 1.1 0.0017 18.3 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain PSI PF01437.23 MSTRG.3146.1_1 - 0.0033 17.8 6.4 0.0085 16.5 6.4 1.8 1 0 0 1 1 1 1 Plexin repeat I-set PF07679.14 MSTRG.3146.1_1 - 0.0059 16.5 0.0 0.0099 15.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain PapC_C PF13953.4 MSTRG.3146.1_1 - 0.026 14.3 0.0 0.054 13.2 0.0 1.5 1 0 0 1 1 1 0 PapC C-terminal domain Bromodomain PF00439.23 MSTRG.17401.1_3 - 8.9e-17 60.8 0.1 1.6e-16 60.0 0.1 1.4 1 0 0 1 1 1 1 Bromodomain PHD PF00628.27 MSTRG.17401.1_3 - 1.9e-07 30.7 5.9 1.9e-07 30.7 5.9 4.1 3 0 0 3 3 3 1 PHD-finger zf-B_box PF00643.22 MSTRG.17401.1_3 - 1.3e-06 28.3 11.1 1.3e-06 28.3 11.1 4.0 4 0 0 4 4 4 2 B-box zinc finger AF0941-like PF14591.4 MSTRG.17401.1_3 - 0.3 11.5 2.1 0.71 10.3 2.1 1.5 1 0 0 1 1 1 0 AF0941-like DUF745 PF05335.11 MSTRG.17401.1_3 - 2 8.0 5.4 3.5 7.2 5.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Calpain_inhib PF00748.17 MSTRG.13717.6_1 - 2.1e-94 312.8 81.8 2.4e-32 112.1 6.4 6.8 5 2 0 5 5 5 5 Calpain inhibitor zinc_ribbon_9 PF14369.4 MSTRG.11002.1_2 - 0.43 10.7 0.1 0.43 10.7 0.1 2.5 3 0 0 3 3 3 0 zinc-ribbon PRY PF13765.4 MSTRG.12938.1_1 - 1.1e-16 60.0 0.1 2.8e-16 58.7 0.1 1.8 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 MSTRG.12938.1_1 - 1.6e-08 34.5 0.0 3.1e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 SPRY domain U-box PF04564.13 MSTRG.12938.1_1 - 1.9e-08 34.2 0.0 4.2e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-C3HC4_2 PF13923.4 MSTRG.12938.1_1 - 2.5e-08 33.5 12.7 9.3e-08 31.7 12.7 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 MSTRG.12938.1_1 - 3.1e-08 33.2 11.6 3.1e-08 33.2 11.6 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.12938.1_1 - 6.8e-08 32.3 8.6 6.8e-08 32.3 8.6 2.5 2 1 0 2 2 1 1 RING-type zinc-finger zf-B_box PF00643.22 MSTRG.12938.1_1 - 3.2e-07 30.3 9.0 3.2e-07 30.3 9.0 3.4 2 1 0 2 2 1 1 B-box zinc finger zf-C3HC4_4 PF15227.4 MSTRG.12938.1_1 - 1.4e-06 28.2 12.5 1.4e-06 28.2 12.5 2.6 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 MSTRG.12938.1_1 - 1.8e-06 27.6 12.4 1.8e-06 27.6 12.4 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 MSTRG.12938.1_1 - 1.1e-05 25.2 12.1 1.1e-05 25.2 12.1 2.6 2 1 0 2 2 1 1 zinc-RING finger domain zf-RING_2 PF13639.4 MSTRG.12938.1_1 - 0.00021 21.3 15.3 0.00021 21.3 15.3 2.7 2 0 0 2 2 1 1 Ring finger domain Prok-RING_4 PF14447.4 MSTRG.12938.1_1 - 0.0017 18.0 15.0 0.0017 18.0 15.0 3.2 2 1 1 3 3 2 1 Prokaryotic RING finger family 4 Acetyltransf_16 PF05301.9 MSTRG.12938.1_1 - 0.03 13.9 0.1 0.05 13.2 0.1 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase, Mec-17 Med30 PF11315.6 MSTRG.12938.1_1 - 0.092 12.9 6.5 0.18 12.0 6.5 1.4 1 0 0 1 1 1 0 Mediator complex subunit 30 CK2S PF15011.4 MSTRG.12938.1_1 - 0.42 10.3 7.1 27 4.4 7.8 2.6 2 1 0 2 2 2 0 Casein Kinase 2 substrate NPV_P10 PF05531.10 MSTRG.12938.1_1 - 0.46 10.8 2.6 9.3 6.7 0.2 2.4 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Cep57_MT_bd PF06657.11 MSTRG.12938.1_1 - 0.62 10.4 9.7 0.12 12.7 2.7 2.4 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DASH_Dam1 PF08653.8 MSTRG.12938.1_1 - 0.64 9.7 3.3 13 5.5 0.4 2.6 2 0 0 2 2 2 0 DASH complex subunit Dam1 DUF1664 PF07889.10 MSTRG.12938.1_1 - 1.8 8.5 7.5 4.7 7.1 1.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Ribosomal_L37e PF01907.17 MSTRG.12938.1_1 - 2 8.5 8.2 4.9 7.3 8.2 1.7 1 0 0 1 1 1 0 Ribosomal protein L37e COG2 PF06148.9 MSTRG.12938.1_1 - 3 7.8 7.4 14 5.7 1.6 2.3 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 YtxH PF12732.5 MSTRG.12938.1_1 - 5.4 7.5 6.0 2.6e+02 2.1 6.0 2.4 1 1 0 1 1 1 0 YtxH-like protein DENN PF02141.19 MSTRG.17392.1_3 - 1.5e-60 204.2 3.6 2.2e-60 203.6 3.6 1.2 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.16 MSTRG.17392.1_3 - 8.8e-15 55.1 0.0 2.8e-14 53.6 0.0 1.9 1 0 0 1 1 1 1 uDENN domain Myosin_head PF00063.19 MSTRG.27308.2_3 - 1.3e-118 396.9 0.0 1.3e-118 396.9 0.0 2.6 3 1 0 3 3 3 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 MSTRG.27308.2_3 - 8.4e-16 56.9 169.0 1.4e-14 52.8 101.4 3.9 1 1 1 2 2 2 2 Myosin tail PDZ PF00595.22 MSTRG.27308.2_3 - 5e-09 36.3 0.0 1.6e-08 34.6 0.0 2.0 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.27308.2_3 - 0.11 12.7 0.0 0.51 10.6 0.0 2.1 1 0 0 1 1 1 0 PDZ domain DUF258 PF03193.14 MSTRG.27308.2_3 - 0.14 12.0 5.0 0.38 10.5 0.0 3.7 3 1 0 3 3 3 0 Protein of unknown function, DUF258 AAA_22 PF13401.4 MSTRG.27308.2_3 - 0.14 12.3 0.0 0.14 12.3 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_16 PF13191.4 MSTRG.27308.2_3 - 0.16 12.2 0.0 0.16 12.2 0.0 4.8 4 1 1 5 5 5 0 AAA ATPase domain ABC_tran PF00005.25 MSTRG.27308.2_3 - 0.2 12.0 0.0 0.2 12.0 0.0 5.7 2 1 0 2 2 2 0 ABC transporter IQ PF00612.25 MSTRG.27308.2_3 - 0.21 11.3 4.6 0.064 12.9 0.6 2.5 2 0 0 2 2 2 0 IQ calmodulin-binding motif ATG16 PF08614.9 MSTRG.27308.2_3 - 2.7 8.0 153.8 0.015 15.4 15.5 7.6 2 1 5 7 7 7 0 Autophagy protein 16 (ATG16) MACPF PF01823.17 MSTRG.1822.3_3 - 8.5e-28 97.7 1.4 1.5e-27 97.0 1.4 1.3 1 0 0 1 1 1 1 MAC/Perforin domain GED PF02212.16 MSTRG.12695.3_1 - 0.088 12.8 1.7 0.23 11.5 1.7 1.7 1 0 0 1 1 1 0 Dynamin GTPase effector domain SHNi-TPR PF10516.7 MSTRG.12695.3_3 - 6.4e-16 57.4 1.8 4.8e-14 51.4 0.7 2.5 2 0 0 2 2 2 1 SHNi-TPR TPR_12 PF13424.4 MSTRG.12695.3_3 - 4.1e-10 39.7 4.6 1.5e-09 37.8 1.0 2.6 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.12695.3_3 - 5.3e-09 35.4 0.1 0.00072 19.4 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.12695.3_3 - 6.3e-09 35.2 0.0 0.001 18.7 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.12695.3_3 - 9.3e-07 28.5 0.1 0.013 15.5 0.0 3.7 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.12695.3_3 - 0.00039 20.9 0.1 0.66 10.8 0.0 3.5 2 1 1 3 3 2 1 Tetratricopeptide repeat Paf67 PF10255.7 MSTRG.12695.3_3 - 0.0041 16.0 0.0 0.0074 15.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_16 PF13432.4 MSTRG.12695.3_3 - 0.007 16.9 0.9 0.3 11.7 0.0 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.12695.3_3 - 0.018 15.6 0.1 4 8.2 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.12695.3_3 - 0.038 13.6 0.4 15 5.2 0.0 3.7 4 1 1 5 5 5 0 TPR repeat TPR_7 PF13176.4 MSTRG.12695.3_3 - 0.048 13.6 0.3 1.8 8.7 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.12695.3_3 - 0.37 10.9 4.6 1.6 8.8 2.2 3.1 2 2 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.4 MSTRG.12695.3_3 - 0.59 10.6 4.3 1.9 9.0 0.5 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.12695.3_3 - 2.1 8.2 7.1 0.39 10.5 0.1 3.4 5 0 0 5 5 5 0 Tetratricopeptide repeat Herpes_UL56 PF04534.10 MSTRG.16796.1_2 - 0.011 15.1 0.3 0.012 15.0 0.3 1.1 1 0 0 1 1 1 0 Herpesvirus UL56 protein Bcl-2 PF00452.17 MSTRG.551.3_2 - 2.2e-31 108.3 0.0 4.5e-31 107.2 0.0 1.6 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family BH4 PF02180.15 MSTRG.551.3_2 - 2.7e-07 30.1 0.2 4.9e-07 29.3 0.2 1.4 1 0 0 1 1 1 1 Bcl-2 homology region 4 Bcl-2_3 PF15286.4 MSTRG.551.3_2 - 0.0019 18.7 0.0 0.003 18.1 0.0 1.3 1 0 0 1 1 1 1 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like Pkinase PF00069.23 MSTRG.5314.1_2 - 3.6e-52 177.2 0.0 6.9e-52 176.3 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.5314.1_2 - 1.7e-41 142.1 0.0 2.8e-41 141.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.6 MSTRG.5314.1_2 - 9.9e-17 60.5 0.4 6.6e-14 51.4 0.0 2.5 2 0 0 2 2 2 2 Oxidative-stress-responsive kinase 1 C terminal DUF2956 PF11169.6 MSTRG.5314.1_2 - 0.042 13.9 0.0 0.14 12.2 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) DCX PF03607.15 MSTRG.9396.1_3 - 9.2e-41 137.6 0.0 2.5e-19 69.0 0.0 2.5 2 0 0 2 2 2 2 Doublecortin LRR_8 PF13855.4 MSTRG.18545.2_1 - 1.2e-12 47.3 10.2 7e-12 44.8 7.5 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.5 MSTRG.18545.2_1 - 5.4e-09 36.0 14.3 9.9e-07 28.8 1.4 2.5 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 MSTRG.18545.2_1 - 0.00038 19.9 0.8 0.00072 19.0 0.8 1.4 1 0 0 1 1 1 1 Leucine-rich repeat Exo_endo_phos PF03372.21 MSTRG.18545.2_1 - 0.00039 20.5 0.0 0.00073 19.6 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_6 PF13516.4 MSTRG.18545.2_1 - 0.12 12.3 7.7 5 7.3 2.1 3.6 3 0 0 3 3 3 0 Leucine Rich repeat LRR_1 PF00560.31 MSTRG.18545.2_1 - 0.84 10.2 11.5 34 5.3 0.1 4.5 4 0 0 4 4 4 0 Leucine Rich Repeat Sec7 PF01369.18 MSTRG.14558.1_1 - 1e-61 207.7 1.0 1.7e-61 207.0 1.0 1.4 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.5 MSTRG.14558.1_1 - 7.2e-27 94.2 9.3 7.2e-27 94.2 9.3 4.3 3 1 1 4 4 4 3 Guanine nucleotide exchange factor in Golgi transport N-terminal Na_K-ATPase PF00287.16 MSTRG.8211.1_1 - 3.2e-107 357.8 0.0 4.1e-107 357.4 0.0 1.1 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain DNA_pol_B PF00136.19 MSTRG.6453.1_1 - 6.7e-151 503.0 0.1 9.2e-151 502.5 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.17 MSTRG.6453.1_1 - 4.5e-86 288.9 0.0 6.9e-86 288.3 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.4 MSTRG.6453.1_1 - 8.6e-11 42.0 7.2 2.1e-10 40.8 7.2 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.11 MSTRG.6453.1_1 - 0.017 13.9 0.8 0.038 12.7 0.1 1.8 2 0 0 2 2 2 0 DNA polymerase type B, organellar and viral DZR PF12773.5 MSTRG.6453.1_1 - 0.97 9.4 4.2 1.6 8.7 0.9 1.8 1 1 1 2 2 2 0 Double zinc ribbon SHMT PF00464.17 MSTRG.18696.3_2 - 1.1e-206 686.0 0.0 1.5e-206 685.6 0.0 1.1 1 0 0 1 1 1 1 Serine hydroxymethyltransferase DegT_DnrJ_EryC1 PF01041.15 MSTRG.18696.3_2 - 0.069 12.3 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family TSC22 PF01166.16 MSTRG.20028.2_3 - 1.7e-28 98.6 6.6 2.5e-28 98.0 6.6 1.3 1 0 0 1 1 1 1 TSC-22/dip/bun family DUF972 PF06156.11 MSTRG.20028.2_3 - 0.00016 22.1 2.3 0.00025 21.5 2.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF972) DivIC PF04977.13 MSTRG.20028.2_3 - 0.003 17.2 2.9 0.006 16.2 2.9 1.5 1 0 0 1 1 1 1 Septum formation initiator SOGA PF11365.6 MSTRG.20028.2_3 - 0.0076 17.2 0.5 0.012 16.6 0.5 1.3 1 0 0 1 1 1 1 Protein SOGA ZapB PF06005.10 MSTRG.20028.2_3 - 0.0095 16.2 5.3 0.018 15.3 5.3 1.3 1 0 0 1 1 1 1 Cell division protein ZapB K-box PF01486.15 MSTRG.20028.2_3 - 0.012 15.6 2.1 0.019 15.0 2.1 1.2 1 0 0 1 1 1 0 K-box region Chibby PF14645.4 MSTRG.20028.2_3 - 0.038 14.3 0.2 0.059 13.6 0.2 1.3 1 0 0 1 1 1 0 Chibby family Fzo_mitofusin PF04799.11 MSTRG.20028.2_3 - 0.26 10.7 2.7 0.38 10.1 2.7 1.2 1 0 0 1 1 1 0 fzo-like conserved region bZIP_2 PF07716.13 MSTRG.20028.2_3 - 0.29 11.1 6.5 0.5 10.4 6.5 1.3 1 0 0 1 1 1 0 Basic region leucine zipper PP1_bind PF15276.4 MSTRG.16600.2_3 - 3.5e-17 62.4 2.5 3.5e-17 62.4 2.5 2.8 2 0 0 2 2 2 1 Protein phosphatase 1 binding Neur_chan_LBD PF02931.21 MSTRG.9724.1_1 - 9.3e-49 165.7 0.0 1.2e-48 165.2 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 MSTRG.9724.1_1 - 2.3e-43 148.8 0.2 4.8e-43 147.8 0.2 1.5 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Fez1 PF06818.13 MSTRG.26216.1_2 - 6.1e-29 101.8 14.1 1.1e-28 100.9 14.1 1.4 1 0 0 1 1 1 1 Fez1 DUF2735 PF10931.6 MSTRG.6171.1_2 - 0.15 12.7 0.1 0.22 12.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2735) Vps8 PF12816.5 MSTRG.14551.2_3 - 7.5e-54 182.1 0.1 1.2e-53 181.4 0.1 1.3 1 0 0 1 1 1 1 Golgi CORVET complex core vacuolar protein 8 ANAPC4_WD40 PF12894.5 MSTRG.14551.2_3 - 0.0026 17.9 0.1 1.3 9.3 0.0 3.7 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 MSTRG.14551.2_3 - 0.12 13.1 2.7 23 5.9 0.0 4.3 3 1 0 3 3 3 0 WD domain, G-beta repeat PQQ_2 PF13360.4 MSTRG.14551.2_3 - 0.15 11.4 0.0 0.46 9.9 0.0 1.8 2 0 0 2 2 2 0 PQQ-like domain NAD_binding_6 PF08030.10 MSTRG.20078.1_3 - 1.7e-32 112.5 0.0 7.1e-32 110.6 0.0 2.0 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.17 MSTRG.20078.1_3 - 2.5e-25 88.9 8.6 2.5e-25 88.9 8.6 2.4 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.10 MSTRG.20078.1_3 - 4.4e-22 78.1 0.0 9.1e-22 77.1 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain FAD_binding_6 PF00970.22 MSTRG.20078.1_3 - 0.00071 19.8 0.0 0.0014 18.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.19 MSTRG.20078.1_3 - 0.042 14.4 0.0 0.25 11.9 0.0 2.3 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain Aminotran_3 PF00202.19 MSTRG.17911.1_2 - 1.3e-119 399.3 0.0 1.6e-119 399.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III LRR_8 PF13855.4 MSTRG.23488.1_2 - 3.3e-76 250.8 67.9 3.2e-15 55.5 3.3 6.4 2 1 6 8 8 8 8 Leucine rich repeat LRR_4 PF12799.5 MSTRG.23488.1_2 - 2.1e-27 94.5 33.2 4.2e-08 33.2 0.7 7.1 3 1 2 7 7 7 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 MSTRG.23488.1_2 - 6.2e-20 71.3 0.0 1.5e-09 37.7 0.0 3.0 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_9 PF14580.4 MSTRG.23488.1_2 - 2.4e-16 59.6 7.4 1.5e-05 24.4 0.5 4.1 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.31 MSTRG.23488.1_2 - 8e-10 37.6 28.6 2 9.1 0.9 10.1 11 0 0 11 11 11 4 Leucine Rich Repeat LRR_6 PF13516.4 MSTRG.23488.1_2 - 0.0001 21.9 34.2 2.2 8.4 0.5 9.1 9 0 0 9 9 9 4 Leucine Rich repeat FNIP PF05725.10 MSTRG.23488.1_2 - 0.29 11.2 6.5 2 8.5 2.0 3.9 3 1 1 4 4 4 0 FNIP Repeat Arf PF00025.19 MSTRG.20140.3_3 - 3e-43 147.2 0.0 4.4e-43 146.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 MSTRG.20140.3_3 - 2.3e-08 34.1 0.0 4.8e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 MSTRG.20140.3_3 - 2.7e-08 33.3 0.0 5.7e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.20 MSTRG.20140.3_3 - 3.4e-08 33.1 0.0 5.9e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Ras family G-alpha PF00503.18 MSTRG.20140.3_3 - 6.9e-07 28.6 1.6 0.00032 19.8 0.0 3.1 2 1 1 3 3 3 1 G-protein alpha subunit MMR_HSR1 PF01926.21 MSTRG.20140.3_3 - 1.4e-05 25.0 0.0 2.9e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase BUD22 PF09073.8 MSTRG.20140.3_3 - 0.025 13.8 15.5 0.033 13.4 15.5 1.1 1 0 0 1 1 1 0 BUD22 PHD PF00628.27 MSTRG.26026.4_3 - 3.2e-18 65.2 27.7 7.1e-10 38.5 6.7 2.8 2 0 0 2 2 2 2 PHD-finger WSD PF15613.4 MSTRG.26026.4_3 - 2.3e-08 34.3 4.3 2.3e-08 34.3 4.3 5.3 5 2 0 5 5 5 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif WHIM1 PF15612.4 MSTRG.26026.4_3 - 0.0062 15.9 0.0 0.033 13.7 0.0 2.2 2 0 0 2 2 2 1 WSTF, HB1, Itc1p, MBD9 motif 1 PHD_2 PF13831.4 MSTRG.26026.4_3 - 0.2 11.1 15.1 0.72 9.3 2.0 2.6 2 0 0 2 2 2 0 PHD-finger Ig_3 PF13927.4 MSTRG.15208.1_1 - 4.6e-33 113.5 0.0 2.5e-10 40.7 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.15208.1_1 - 1.8e-24 85.7 0.0 3.3e-07 30.4 0.0 3.7 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.23 MSTRG.15208.1_1 - 6.4e-22 77.4 0.0 3.3e-06 27.0 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 MSTRG.15208.1_1 - 8.5e-22 76.9 0.0 2.1e-08 33.9 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain V-set PF07686.15 MSTRG.15208.1_1 - 4.4e-09 36.3 1.4 0.17 11.9 0.1 4.6 3 3 0 3 3 3 3 Immunoglobulin V-set domain Izumo-Ig PF16706.3 MSTRG.15208.1_1 - 0.016 15.1 0.0 7.7 6.5 0.0 3.0 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Prothymosin PF03247.12 MSTRG.21025.1_3 - 1.3e-19 70.6 35.1 1.7e-19 70.2 35.1 1.2 1 0 0 1 1 1 1 Prothymosin/parathymosin family HMMR_N PF15905.3 MSTRG.29485.1_2 - 0.0054 16.1 7.4 0.0064 15.9 7.4 1.0 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal CENP-F_leu_zip PF10473.7 MSTRG.29485.1_2 - 0.29 11.0 12.7 2.9 7.8 8.5 2.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Trypsin PF00089.24 MSTRG.804.1_2 - 1.7e-66 224.1 0.0 2.3e-66 223.6 0.0 1.2 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 MSTRG.804.1_2 - 3.8e-08 34.2 0.0 6.5e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 MSTRG.804.1_2 - 0.12 12.6 0.0 0.26 11.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Hormone_2 PF00123.18 MSTRG.20222.1_2 - 1.1e-25 89.1 1.5 2e-12 46.7 0.1 2.6 2 0 0 2 2 2 2 Peptide hormone Lipoprotein_10 PF03202.11 MSTRG.20222.1_2 - 0.062 13.6 0.6 0.79 10.0 0.1 2.1 1 1 1 2 2 2 0 Putative mycoplasma lipoprotein, C-terminal region RabGAP-TBC PF00566.16 MSTRG.23984.1_2 - 1.4e-15 57.5 2.1 2.8e-15 56.4 2.1 1.6 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Rhodanese PF00581.18 MSTRG.23984.1_2 - 9.9e-08 32.3 0.0 2.1e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain SBP56 PF05694.9 MSTRG.3655.3_1 - 1.6e-127 426.0 0.0 2.1e-127 425.6 0.0 1.1 1 0 0 1 1 1 1 56kDa selenium binding protein (SBP56) DDE_Tnp_1_7 PF13843.4 MSTRG.3655.3_2 - 1.2e-50 172.7 0.0 1.7e-50 172.2 0.0 1.2 1 0 0 1 1 1 1 Transposase IS4 SBP56 PF05694.9 MSTRG.3655.3_2 - 7.5e-35 120.5 0.0 1.2e-34 119.8 0.0 1.2 1 0 0 1 1 1 1 56kDa selenium binding protein (SBP56) DDE_1 PF03184.17 MSTRG.3655.3_2 - 3.5e-06 26.6 0.0 6.8e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.14 MSTRG.3655.3_2 - 0.0031 17.4 0.0 0.007 16.2 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DUF1830 PF08865.9 MSTRG.23877.1_2 - 0.16 11.9 0.0 0.29 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1830) RNase_PH PF01138.19 MSTRG.19196.1_1 - 2.2e-23 83.1 0.0 4e-23 82.2 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.13 MSTRG.19196.1_1 - 6.2e-11 42.0 0.6 1.6e-09 37.5 0.0 2.4 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 LAM_C PF12544.6 MSTRG.19196.1_1 - 0.85 9.7 3.0 1.5 8.9 3.0 1.3 1 0 0 1 1 1 0 Lysine-2,3-aminomutase Peptidase_C1 PF00112.21 MSTRG.8671.2_1 - 4.1e-86 288.5 4.2 4.8e-86 288.3 4.2 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.13 MSTRG.8671.2_1 - 1.3e-05 24.1 1.6 0.0003 19.5 0.2 2.1 2 0 0 2 2 2 2 Peptidase C1-like family SAP PF02037.25 MSTRG.27146.3_3 - 3.8e-12 45.5 3.4 6.7e-12 44.7 3.4 1.4 1 0 0 1 1 1 1 SAP domain Fn_bind PF02986.12 MSTRG.27146.3_3 - 0.012 15.1 0.3 4.3 7.0 0.1 2.8 2 0 0 2 2 2 0 Fibronectin binding repeat Telomere_Sde2_2 PF13297.4 MSTRG.27146.3_3 - 0.12 12.0 0.4 0.23 11.0 0.4 1.4 1 0 0 1 1 1 0 Telomere stability C-terminal GLTSCR1 PF15249.4 MSTRG.809.2_2 - 2.3e-28 98.5 2.8 4.2e-28 97.7 2.8 1.4 1 0 0 1 1 1 1 Conserved region of unknown function on GLTSCR protein Cadherin PF00028.15 MSTRG.20551.1_2 - 3.6e-25 88.1 3.7 3.3e-08 33.7 0.1 4.4 4 1 0 4 4 4 3 Cadherin domain DUF3959 PF13105.4 MSTRG.6995.2_1 - 0.046 13.1 0.3 0.091 12.1 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) RA PF00788.21 MSTRG.19226.1_3 - 6.6e-12 45.8 2.9 3.4e-11 43.5 0.5 2.5 1 1 1 2 2 2 1 Ras association (RalGDS/AF-6) domain PH PF00169.27 MSTRG.19226.1_3 - 1.4e-09 38.3 1.6 1.7e-09 38.0 0.1 1.9 2 0 0 2 2 2 1 PH domain FERM_N PF09379.8 MSTRG.19226.1_3 - 0.0053 16.5 0.1 0.011 15.5 0.1 1.5 1 0 0 1 1 1 1 FERM N-terminal domain RBD PF02196.13 MSTRG.19226.1_3 - 0.065 13.2 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 Raf-like Ras-binding domain VWA PF00092.26 MSTRG.23424.1_3 - 1.4e-52 178.4 0.1 1.9e-52 177.9 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain fn3 PF00041.19 MSTRG.23424.1_3 - 6.9e-38 128.8 0.1 1.2e-11 44.7 0.0 3.4 3 0 0 3 3 3 3 Fibronectin type III domain VWA_2 PF13519.4 MSTRG.23424.1_3 - 8.2e-12 45.6 0.0 1.4e-11 44.9 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Pur_ac_phosph_N PF16656.3 MSTRG.23424.1_3 - 1.3e-05 25.5 0.9 0.96 9.9 0.0 4.5 3 3 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.7 MSTRG.23424.1_3 - 0.00086 19.6 0.0 4.6 7.6 0.0 3.6 3 0 0 3 3 3 1 Uncharacterised conserved protein (DUF2369) Tubulin-binding PF00418.17 MSTRG.10200.3_2 - 5.8e-77 253.2 34.5 1.3e-17 63.3 2.0 6.3 6 0 0 6 6 6 6 Tau and MAP protein, tubulin-binding repeat SIS PF01380.20 MSTRG.3005.1_3 - 1.1e-66 222.4 0.1 2.2e-36 124.4 0.0 2.4 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.4 MSTRG.3005.1_3 - 4.4e-15 55.9 0.0 8.4e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.4 MSTRG.3005.1_3 - 8.7e-12 44.9 0.0 1.8e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.4 MSTRG.3005.1_3 - 0.00025 19.9 0.0 0.00039 19.3 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.4 MSTRG.3005.1_3 - 0.0037 17.1 0.0 0.016 15.1 0.0 2.0 2 0 0 2 2 2 1 SIS domain GATase_2 PF00310.19 MSTRG.3005.1_3 - 0.027 13.1 0.0 0.045 12.3 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferases class-II Arf PF00025.19 MSTRG.10298.1_1 - 6.3e-68 227.5 0.1 7.8e-68 227.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 MSTRG.10298.1_1 - 3.2e-13 49.8 0.0 5.2e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 MSTRG.10298.1_1 - 3.7e-13 49.3 0.0 4.9e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 Ras family SRPRB PF09439.8 MSTRG.10298.1_1 - 1.1e-12 47.7 0.0 1.5e-12 47.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 MSTRG.10298.1_1 - 4.1e-10 39.2 0.8 6.3e-06 25.4 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 MSTRG.10298.1_1 - 6.9e-10 38.5 0.0 9.8e-10 38.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 MSTRG.10298.1_1 - 4.8e-08 33.0 0.0 7.2e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_18 PF13238.4 MSTRG.10298.1_1 - 0.0018 18.6 0.0 0.0033 17.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF2028 PF09667.8 MSTRG.11194.1_1 - 1.4e-17 64.2 4.9 1.4e-17 64.2 4.9 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF2028) HMG_box PF00505.17 MSTRG.11194.1_1 - 6.2e-17 61.6 2.9 7.7e-17 61.3 1.7 1.8 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.8 MSTRG.11194.1_1 - 9.7e-10 38.8 1.2 2e-09 37.8 1.2 1.5 1 0 0 1 1 1 1 HMG-box domain Laminin_EGF PF00053.22 MSTRG.2996.1_3 - 0.41 10.7 5.9 8.7 6.5 0.5 2.8 1 1 1 2 2 2 0 Laminin EGF domain Ntox34 PF15606.4 MSTRG.2996.1_3 - 2.2 8.3 7.4 4.7 7.3 1.5 3.7 1 1 1 3 3 3 0 Bacterial toxin 34 Motile_Sperm PF00635.24 MSTRG.9328.2_1 - 3.8e-31 107.0 0.0 6.6e-31 106.3 0.0 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain GIT_CC PF16559.3 MSTRG.9328.2_1 - 0.057 13.3 0.7 0.14 12.1 0.7 1.6 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor ATP-synt_G PF04718.13 MSTRG.9328.2_1 - 0.11 13.3 0.0 0.23 12.2 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial ATP synthase g subunit ASH PF15780.3 MSTRG.9328.2_1 - 0.11 12.5 0.1 0.21 11.6 0.1 1.4 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Arm PF00514.21 MSTRG.15780.1_2 - 1.1e-27 95.0 12.0 2e-07 30.7 0.0 6.8 9 0 0 9 9 9 4 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.4 MSTRG.15780.1_2 - 6.1e-07 29.6 0.5 0.39 11.1 0.0 4.8 5 0 0 5 5 5 2 HEAT-like repeat HEAT_2 PF13646.4 MSTRG.15780.1_2 - 4.6e-05 23.6 0.1 0.09 13.0 0.0 2.6 2 0 0 2 2 2 2 HEAT repeats HEAT PF02985.20 MSTRG.15780.1_2 - 7.1e-05 22.6 0.1 1.3 9.4 0.0 3.8 3 0 0 3 3 3 2 HEAT repeat Atx10homo_assoc PF09759.7 MSTRG.15780.1_2 - 0.0076 16.2 0.2 0.45 10.5 0.0 2.8 3 0 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain C2 PF00168.28 MSTRG.18575.1_1 - 8.7e-11 41.9 0.0 1e-10 41.7 0.0 1.0 1 0 0 1 1 1 1 C2 domain DUF3833 PF12915.5 MSTRG.18575.1_1 - 0.068 12.6 0.0 0.087 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3833) Ribonuc_red_sm PF00268.19 MSTRG.23410.3_3 - 2.9e-125 417.2 2.9 3.7e-125 416.9 2.9 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Ferritin PF00210.22 MSTRG.28195.1_2 - 1.2e-20 73.8 0.3 1.3e-20 73.7 0.3 1.0 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.15 MSTRG.28195.1_2 - 0.019 15.3 0.2 0.021 15.1 0.2 1.1 1 0 0 1 1 1 0 Rubrerythrin FCH PF00611.21 MSTRG.28195.1_2 - 0.15 12.2 1.1 0.32 11.2 1.1 1.8 1 1 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain Neurensin PF14927.4 MSTRG.13342.1_2 - 4e-50 168.9 0.1 6.1e-50 168.3 0.1 1.3 1 0 0 1 1 1 1 Neurensin WD40 PF00400.30 MSTRG.9389.2_2 - 7.6e-22 77.1 11.7 0.0021 18.7 0.1 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.9389.2_2 - 7.8e-05 22.8 0.1 3.4 7.9 0.0 4.3 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain EspF PF04806.10 MSTRG.25869.1_1 - 0.33 11.2 9.1 4.1 7.7 2.7 2.6 2 0 0 2 2 2 0 EspF protein repeat TPR_1 PF00515.26 MSTRG.4761.2_3 - 3.4e-31 105.6 9.3 6.4e-09 35.1 0.2 7.8 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.4761.2_3 - 1.8e-30 102.4 4.0 1.8e-06 27.5 0.2 8.0 7 1 1 8 8 8 6 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.4761.2_3 - 1.4e-24 85.4 5.0 5.1e-07 29.1 0.0 7.3 3 1 4 7 7 7 6 TPR repeat TPR_8 PF13181.4 MSTRG.4761.2_3 - 1.3e-23 81.1 5.9 3.1e-06 26.9 0.2 7.6 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_9 PF13371.4 MSTRG.4761.2_3 - 1.2e-16 60.5 0.5 3.9e-05 23.6 0.0 5.1 1 1 4 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.4761.2_3 - 5.4e-16 58.9 0.0 0.00037 21.0 0.0 4.3 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.4761.2_3 - 5.7e-16 58.4 5.6 4.1e-06 26.9 0.3 5.2 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.4761.2_3 - 4.3e-13 48.8 3.7 0.0086 16.7 0.1 6.3 4 1 2 6 6 5 2 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.4761.2_3 - 5.5e-12 45.9 5.6 6.5e-06 26.4 0.2 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.4761.2_3 - 6.3e-12 44.9 0.3 0.11 12.8 0.0 6.6 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.4761.2_3 - 1.5e-07 30.8 2.3 0.00097 18.9 0.1 4.9 5 1 1 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.4761.2_3 - 3.1e-07 30.4 3.7 5e-05 23.3 0.4 4.2 1 1 2 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.4 MSTRG.4761.2_3 - 4.8e-05 23.6 7.4 0.29 11.7 0.1 6.2 7 0 0 7 7 6 1 Tetratricopeptide repeat SHNi-TPR PF10516.7 MSTRG.4761.2_3 - 0.00055 19.2 8.3 1.4 8.3 0.3 5.2 5 0 0 5 5 5 1 SHNi-TPR TPR_10 PF13374.4 MSTRG.4761.2_3 - 0.0013 18.4 3.9 0.43 10.4 0.1 4.5 4 1 1 5 5 5 1 Tetratricopeptide repeat NARP1 PF12569.6 MSTRG.4761.2_3 - 0.0014 17.5 0.1 0.23 10.2 0.1 2.2 1 1 0 2 2 2 1 NMDA receptor-regulated protein 1 BTAD PF03704.15 MSTRG.4761.2_3 - 0.0022 18.3 0.5 3.6 7.9 0.1 2.8 2 1 0 2 2 2 2 Bacterial transcriptional activator domain STAG PF08514.9 MSTRG.9007.1_1 - 8.6e-37 125.4 1.0 2.2e-36 124.1 0.1 2.2 2 0 0 2 2 2 1 STAG domain Cnd1 PF12717.5 MSTRG.9007.1_1 - 0.0031 17.4 0.4 0.12 12.2 0.0 3.2 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Cnd3 PF12719.5 MSTRG.9007.1_1 - 0.082 12.0 2.7 0.04 13.0 0.2 1.7 2 0 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain Adaptin_N PF01602.18 MSTRG.20454.2_1 - 8.6e-43 146.5 0.0 2.6e-28 98.8 0.0 2.1 2 0 0 2 2 2 2 Adaptin N terminal region Cnd1 PF12717.5 MSTRG.20454.2_1 - 2.4e-24 86.1 0.0 4e-24 85.3 0.0 1.4 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.8 MSTRG.20454.2_1 - 8.2e-05 22.5 0.0 0.00071 19.5 0.0 2.2 2 0 0 2 2 2 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.4 MSTRG.20454.2_1 - 0.029 14.6 0.4 0.79 10.0 0.1 3.2 3 1 1 4 4 4 0 HEAT repeats Glyco_transf_54 PF04666.11 MSTRG.20454.2_3 - 8.8e-87 290.5 1.4 1.3e-86 290.0 1.4 1.1 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Ribosomal_S8e PF01201.20 MSTRG.8418.1_1 - 2.6e-61 205.6 0.5 3.2e-61 205.3 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e RabGAP-TBC PF00566.16 MSTRG.27656.3_1 - 1e-42 146.1 0.4 1.7e-42 145.4 0.4 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Pkinase PF00069.23 MSTRG.27656.3_1 - 8.3e-35 120.3 0.0 1.2e-34 119.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.27656.3_1 - 3.6e-25 88.6 0.0 6.4e-25 87.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.27656.3_1 - 1.2e-05 24.6 0.0 2.3e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like DUF2457 PF10446.7 MSTRG.28871.1_1 - 0.16 11.0 5.0 0.17 10.9 5.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Mito_carr PF00153.25 MSTRG.705.1_3 - 3.6e-53 177.3 7.0 1.9e-20 72.4 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein TPR_1 PF00515.26 MSTRG.26612.1_3 - 9.4e-09 34.6 11.0 0.00053 19.6 0.2 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.26612.1_3 - 1.6e-07 30.7 10.6 0.0016 18.3 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.26612.1_3 - 0.00016 21.5 1.7 0.014 15.4 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.26612.1_3 - 0.0016 18.8 6.0 0.038 14.4 0.8 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.26612.1_3 - 0.032 14.9 0.8 0.16 12.7 0.0 2.4 1 1 2 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 MSTRG.26612.1_3 - 0.099 12.6 2.9 0.12 12.3 1.2 1.9 1 1 1 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.26612.1_3 - 0.11 12.8 2.7 8.6 6.9 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.26612.1_3 - 0.19 12.3 3.6 0.58 10.8 0.1 2.8 3 1 0 3 3 2 0 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.26612.1_3 - 1.1 9.3 7.3 3.8 7.7 2.4 2.1 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.4 MSTRG.26612.1_3 - 2.1 8.0 8.6 3.4 7.3 1.5 2.6 3 0 0 3 3 3 0 TPR repeat TPR_12 PF13424.4 MSTRG.26612.1_3 - 5.7 7.2 7.7 0.83 9.9 1.7 2.4 2 1 1 3 3 3 0 Tetratricopeptide repeat Med4 PF10018.7 MSTRG.29569.1_1 - 0.00037 20.1 6.8 0.00041 19.9 6.8 1.0 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 PKcGMP_CC PF16808.3 MSTRG.29569.1_1 - 0.0066 16.1 8.5 0.0066 16.1 8.5 2.1 1 1 1 2 2 2 1 Coiled-coil N-terminus of cGMP-dependent protein kinase MAT1 PF06391.11 MSTRG.29569.1_1 - 0.023 14.4 5.0 0.027 14.2 5.0 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 DUF3552 PF12072.6 MSTRG.29569.1_1 - 0.15 11.4 9.2 0.16 11.2 9.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Suppressor_APC PF11414.6 MSTRG.29569.1_1 - 0.31 11.0 7.9 0.36 10.8 7.9 1.1 1 0 0 1 1 1 0 Adenomatous polyposis coli tumour suppressor protein PhoU PF01895.17 MSTRG.29569.1_1 - 0.31 11.4 3.8 0.45 10.9 3.8 1.5 1 1 0 1 1 1 0 PhoU domain FliJ PF02050.14 MSTRG.29569.1_1 - 0.33 11.0 11.0 0.44 10.7 11.0 1.0 1 0 0 1 1 1 0 Flagellar FliJ protein DUF2570 PF10828.6 MSTRG.29569.1_1 - 0.72 9.6 7.9 0.9 9.3 7.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) IncA PF04156.12 MSTRG.29569.1_1 - 0.94 9.1 8.5 0.98 9.0 8.5 1.1 1 0 0 1 1 1 0 IncA protein TMF_DNA_bd PF12329.6 MSTRG.29569.1_1 - 1.5 8.7 10.9 17 5.4 10.9 2.5 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF349 PF03993.10 MSTRG.29569.1_1 - 3.3 7.9 8.2 6.6 7.0 1.5 2.3 1 1 1 2 2 2 0 Domain of Unknown Function (DUF349) CD36 PF01130.19 MSTRG.8594.2_3 - 1.8e-145 484.9 0.7 2.1e-145 484.7 0.7 1.0 1 0 0 1 1 1 1 CD36 family G-alpha PF00503.18 MSTRG.19662.1_2 - 2.2e-105 352.6 1.5 2.9e-105 352.2 1.5 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 MSTRG.19662.1_2 - 1.2e-11 44.3 0.7 1.4e-07 31.0 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family LRR_4 PF12799.5 MSTRG.5195.4_1 - 7.7e-18 64.1 17.4 3.5e-06 27.1 5.6 4.3 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 MSTRG.5195.4_1 - 2.6e-13 49.7 3.5 9.6e-06 25.1 0.0 2.9 2 1 0 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.4 MSTRG.5195.4_1 - 2.3e-11 43.1 18.2 3.7e-05 23.3 4.3 4.1 2 1 1 3 3 3 3 Leucine rich repeat LRR_1 PF00560.31 MSTRG.5195.4_1 - 4.2e-05 23.3 16.5 1.3 9.6 0.2 6.6 6 1 0 6 6 6 3 Leucine Rich Repeat LRR_6 PF13516.4 MSTRG.5195.4_1 - 0.013 15.3 20.2 0.59 10.2 0.4 5.5 6 0 0 6 6 6 0 Leucine Rich repeat Gal-bind_lectin PF00337.20 MSTRG.7609.1_1 - 0.19 11.1 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Galactoside-binding lectin Cnd1 PF12717.5 MSTRG.5278.2_2 - 0.033 14.0 0.9 0.11 12.4 0.1 2.3 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 MRC1 PF09444.8 MSTRG.5278.2_2 - 0.46 10.9 3.9 3.9 7.8 4.2 2.2 2 0 0 2 2 2 0 MRC1-like domain Occludin_ELL PF07303.11 MSTRG.259.1_3 - 5.5e-27 94.3 9.9 1.1e-26 93.3 9.9 1.5 1 0 0 1 1 1 1 Occludin homology domain MARVEL PF01284.21 MSTRG.259.1_3 - 2.7e-23 82.5 11.7 3.9e-23 81.9 11.7 1.2 1 0 0 1 1 1 1 Membrane-associating domain Pex24p PF06398.9 MSTRG.259.1_3 - 0.0055 15.6 0.1 6.2 5.6 0.0 3.0 2 1 0 2 2 2 1 Integral peroxisomal membrane peroxin CitMHS PF03600.14 MSTRG.259.1_3 - 0.0082 15.3 1.3 0.0089 15.2 0.0 1.6 2 0 0 2 2 2 1 Citrate transporter DUF2157 PF09925.7 MSTRG.259.1_3 - 0.023 14.4 0.3 1 9.0 0.0 2.5 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) BRE1 PF08647.9 MSTRG.259.1_3 - 0.053 13.5 1.1 0.11 12.4 1.1 1.5 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase PRKG1_interact PF15898.3 MSTRG.259.1_3 - 0.065 14.0 5.1 0.12 13.2 5.1 1.4 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Laminin_II PF06009.10 MSTRG.259.1_3 - 0.17 11.8 0.4 0.29 11.0 0.4 1.2 1 0 0 1 1 1 0 Laminin Domain II SAS4 PF15460.4 MSTRG.259.1_3 - 0.24 11.4 3.7 0.44 10.5 3.7 1.4 1 0 0 1 1 1 0 Something about silencing, SAS, complex subunit 4 HisKA_7TM PF16927.3 MSTRG.259.1_3 - 0.31 10.9 13.6 0.32 10.9 9.0 2.4 2 1 0 2 2 2 0 N-terminal 7TM region of histidine kinase KxDL PF10241.7 MSTRG.259.1_3 - 0.48 10.6 3.6 0.19 11.9 0.3 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein DUF2070 PF09843.7 MSTRG.259.1_3 - 1.6 6.8 7.5 2.8 6.0 7.5 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Oxidored_q3 PF00499.18 MSTRG.259.1_3 - 2.8 7.6 13.0 1.4 8.6 9.7 2.1 2 1 1 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF2516 PF10724.7 MSTRG.259.1_3 - 6.9 6.9 16.2 1 9.6 3.4 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2516) Wzy_C_2 PF11846.6 MSTRG.259.1_3 - 9.6 5.9 10.9 0.16 11.7 2.0 2.3 3 0 0 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal DEK_C PF08766.9 MSTRG.3065.3_1 - 1.7e-15 56.5 0.5 2.5e-15 56.0 0.5 1.2 1 0 0 1 1 1 1 DEK C terminal domain FERM_C PF09380.8 MSTRG.23892.1_1 - 1.8e-25 89.0 0.2 3.5e-25 88.1 0.2 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FA PF08736.9 MSTRG.23892.1_1 - 1.4e-16 60.2 5.4 4.4e-16 58.6 5.4 1.9 1 0 0 1 1 1 1 FERM adjacent (FA) FERM_M PF00373.16 MSTRG.23892.1_1 - 5e-13 49.4 0.1 9.5e-13 48.5 0.1 1.5 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.8 MSTRG.23892.1_1 - 2.4e-10 40.0 0.0 7.1e-10 38.6 0.0 1.8 1 0 0 1 1 1 1 FERM N-terminal domain RhoGEF PF00621.18 MSTRG.23892.1_1 - 0.028 14.5 0.6 0.062 13.4 0.6 1.6 1 0 0 1 1 1 0 RhoGEF domain Nucleo_P87 PF07267.9 MSTRG.23892.1_1 - 0.27 9.9 1.0 0.36 9.5 1.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF2076 PF09849.7 MSTRG.23892.1_1 - 0.7 9.7 3.5 1.1 9.0 3.5 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Peptidase_M28 PF04389.15 MSTRG.17981.1_2 - 2.6e-44 151.1 0.0 3.6e-44 150.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 PHTB1_C PF14728.4 MSTRG.3560.1_1 - 1.7e-103 346.5 0.3 2e-103 346.3 0.3 1.0 1 0 0 1 1 1 1 PTHB1 C-terminus MARVEL PF01284.21 MSTRG.5180.1_2 - 3.2e-30 104.9 8.9 3.2e-30 104.9 8.9 2.0 2 0 0 2 2 2 1 Membrane-associating domain PDE6_gamma PF04868.10 MSTRG.5180.1_2 - 0.079 13.1 2.0 0.15 12.2 2.0 1.4 1 0 0 1 1 1 0 Retinal cGMP phosphodiesterase, gamma subunit FAM27 PF15832.3 MSTRG.5180.1_3 - 0.022 15.2 8.0 0.042 14.2 8.0 1.5 1 0 0 1 1 1 0 FAM27 D and E protein family ABC_tran PF00005.25 MSTRG.4614.1_3 - 4.8e-07 30.2 0.0 1.1e-06 29.1 0.0 1.6 1 0 0 1 1 1 1 ABC transporter zf-H2C2_2 PF13465.4 MSTRG.16727.1_2 - 4.8e-25 86.7 20.1 1.8e-08 34.3 0.7 5.2 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.16727.1_2 - 2.3e-19 68.5 26.5 7.4e-06 26.0 1.0 4.4 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.16727.1_2 - 3.8e-14 52.0 25.5 0.00074 20.0 0.8 4.4 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.16727.1_2 - 1.4e-06 27.9 21.2 0.00044 20.0 0.5 4.4 4 0 0 4 4 4 2 C2H2-type zinc finger zf-met PF12874.5 MSTRG.16727.1_2 - 5.9e-06 26.4 24.4 0.0061 16.8 1.8 4.4 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 MSTRG.16727.1_2 - 4.7e-05 22.9 15.4 0.66 9.7 0.4 4.3 4 0 0 4 4 4 3 zinc-finger C2H2-type DUF3268 PF11672.6 MSTRG.16727.1_2 - 0.0057 16.9 3.8 0.8 9.9 0.2 2.3 2 0 0 2 2 2 2 zinc-finger-containing domain C1_2 PF03107.14 MSTRG.16727.1_2 - 0.032 14.4 15.7 0.55 10.5 0.3 3.5 2 1 2 4 4 3 0 C1 domain zf-LYAR PF08790.9 MSTRG.16727.1_2 - 0.042 13.6 0.5 0.042 13.6 0.5 3.9 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger zf-C2H2_8 PF15909.3 MSTRG.16727.1_2 - 0.043 14.0 9.2 0.073 13.2 2.6 2.2 1 1 1 2 2 2 0 C2H2-type zinc ribbon Elf1 PF05129.11 MSTRG.16727.1_2 - 0.052 13.5 7.8 0.8 9.7 2.3 2.5 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zinc_ribbon_15 PF17032.3 MSTRG.16727.1_2 - 0.069 13.8 6.1 0.52 11.0 1.0 2.2 1 1 0 2 2 2 0 zinc-ribbon family ADK_lid PF05191.12 MSTRG.16727.1_2 - 0.072 13.0 5.4 1.4 8.9 0.6 2.8 2 0 0 2 2 2 0 Adenylate kinase, active site lid Zn-ribbon_8 PF09723.8 MSTRG.16727.1_2 - 0.075 13.0 8.5 0.34 10.9 2.0 3.0 2 1 0 2 2 2 0 Zinc ribbon domain CpXC PF14353.4 MSTRG.16727.1_2 - 0.18 11.7 6.5 5.5 6.9 0.0 3.8 4 0 0 4 4 4 0 CpXC protein zf-C2HE PF16278.3 MSTRG.16727.1_2 - 0.26 11.6 14.7 0.43 10.9 1.8 3.3 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger LIM PF00412.20 MSTRG.16727.1_2 - 0.27 11.4 11.7 3.1 8.0 3.9 3.2 1 1 2 3 3 3 0 LIM domain zf-Di19 PF05605.10 MSTRG.16727.1_2 - 0.31 11.2 11.8 0.38 10.9 1.7 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DUF2256 PF10013.7 MSTRG.16727.1_2 - 0.36 10.9 9.7 11 6.1 0.2 4.2 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-Sec23_Sec24 PF04810.13 MSTRG.16727.1_2 - 0.41 10.6 6.5 0.75 9.8 0.3 3.3 2 1 1 3 3 3 0 Sec23/Sec24 zinc finger SprT-like PF10263.7 MSTRG.16727.1_2 - 0.47 10.2 8.9 6.9 6.4 8.0 2.2 1 1 1 2 2 2 0 SprT-like family YhfH PF14149.4 MSTRG.16727.1_2 - 0.9 9.4 7.2 15 5.6 0.1 3.5 4 0 0 4 4 4 0 YhfH-like protein zf-trcl PF13451.4 MSTRG.16727.1_2 - 0.96 9.3 11.7 3.7 7.4 0.1 3.5 3 1 0 3 3 3 0 Probable zinc-ribbon domain HypA PF01155.17 MSTRG.16727.1_2 - 1.7 8.5 6.7 1.3 8.9 0.7 2.2 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FYVE PF01363.19 MSTRG.16727.1_2 - 2.1 8.4 12.7 1.5 8.8 1.4 2.5 2 1 0 2 2 2 0 FYVE zinc finger DUF2180 PF09947.7 MSTRG.16727.1_2 - 4.2 7.3 6.4 19 5.2 0.1 3.0 1 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2180) zf-C2H2_2 PF12756.5 MSTRG.16727.1_2 - 4.3 7.6 15.4 21 5.4 0.5 3.9 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) Fer4_10 PF13237.4 MSTRG.16727.1_2 - 7.7 6.6 8.0 3.2 7.8 0.5 2.9 2 1 1 3 3 3 0 4Fe-4S dicluster domain Arf PF00025.19 MSTRG.1879.1_1 - 1e-30 106.3 0.0 1.5e-30 105.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 MSTRG.1879.1_1 - 7.6e-06 26.0 0.0 1.2e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 MSTRG.1879.1_1 - 8.1e-05 22.0 0.0 0.0002 20.7 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.20 MSTRG.1879.1_1 - 0.025 14.0 0.0 0.038 13.4 0.0 1.2 1 0 0 1 1 1 0 Ras family MMR_HSR1 PF01926.21 MSTRG.1879.1_1 - 0.035 14.1 0.0 0.11 12.4 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase RFXA_RFXANK_bdg PF15289.4 MSTRG.21972.1_3 - 0.15 12.2 0.0 0.19 11.9 0.0 1.2 1 0 0 1 1 1 0 Regulatory factor X-associated C-terminal binding domain RRM_1 PF00076.20 MSTRG.797.4_1 - 2.2e-20 72.1 0.0 3.3e-20 71.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 MSTRG.797.4_1 - 0.022 14.6 0.0 0.038 13.8 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF1777 PF08648.10 MSTRG.797.4_1 - 1.3 9.1 47.0 2.7 8.1 47.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) Sulfotransfer_1 PF00685.25 MSTRG.21435.2_1 - 2.2e-69 233.8 0.2 3.3e-69 233.2 0.2 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 MSTRG.21435.2_1 - 4.1e-07 30.5 0.0 1.5e-06 28.6 0.0 1.8 1 1 1 2 2 2 1 Sulfotransferase family zf-UBR PF02207.18 MSTRG.23406.1_1 - 5.9e-13 48.7 11.2 5.9e-13 48.7 11.2 3.1 2 1 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) Myosin_tail_1 PF01576.17 MSTRG.17318.1_1 - 4.4e-48 163.8 164.0 3.6e-37 127.7 60.4 3.0 1 1 1 2 2 2 2 Myosin tail DUF4201 PF13870.4 MSTRG.17318.1_1 - 0.00019 21.0 15.3 0.00019 21.0 15.3 7.5 2 1 5 7 7 7 1 Domain of unknown function (DUF4201) Spc7 PF08317.9 MSTRG.17318.1_1 - 0.0011 17.8 18.7 0.0011 17.8 18.7 6.3 2 1 4 6 6 6 2 Spc7 kinetochore protein TPR_MLP1_2 PF07926.10 MSTRG.17318.1_1 - 0.0074 16.2 23.1 0.0074 16.2 23.1 9.1 2 1 8 10 10 10 2 TPR/MLP1/MLP2-like protein Reo_sigmaC PF04582.10 MSTRG.17318.1_1 - 0.016 14.5 41.2 0.17 11.1 3.8 6.1 1 1 4 7 7 7 0 Reovirus sigma C capsid protein Filament PF00038.19 MSTRG.17318.1_1 - 0.02 14.4 142.5 0.2 11.1 16.3 6.9 1 1 4 6 6 6 0 Intermediate filament protein GRAM PF02893.18 MSTRG.25803.4_1 - 4.7e-13 48.8 0.0 7.4e-13 48.2 0.0 1.3 1 0 0 1 1 1 1 GRAM domain DDE_Tnp_1_7 PF13843.4 MSTRG.17192.1_2 - 9.2e-15 54.7 0.0 1.7e-14 53.8 0.0 1.4 1 1 0 1 1 1 1 Transposase IS4 LRRCT PF01463.22 MSTRG.17192.1_2 - 0.024 15.0 1.0 0.44 11.1 0.1 2.7 2 0 0 2 2 2 0 Leucine rich repeat C-terminal domain Myb_DNA-binding PF00249.29 MSTRG.22852.4_2 - 2.5e-11 43.4 0.2 4.5e-11 42.6 0.2 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 MSTRG.22852.4_2 - 0.059 13.5 0.3 0.12 12.5 0.3 1.5 1 0 0 1 1 1 0 Myb-like DNA-binding domain Ribosomal_60s PF00428.17 MSTRG.22852.4_2 - 0.32 11.4 13.0 1.6 9.2 7.6 2.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF3915 PF13054.4 MSTRG.22852.4_2 - 6.6 6.6 8.3 21 5.0 8.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) A_deaminase PF00962.20 MSTRG.13984.4_2 - 1.7e-128 428.5 0.3 3.8e-128 427.3 0.3 1.6 1 1 0 1 1 1 1 Adenosine/AMP deaminase ER PF01133.15 MSTRG.13984.4_2 - 0.1 12.5 1.7 0.33 10.9 0.5 2.3 2 0 0 2 2 2 0 Enhancer of rudimentary ubiquitin PF00240.21 MSTRG.5481.2_2 - 7.3e-07 28.7 0.0 1.3e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family D123 PF07065.12 MSTRG.20593.1_2 - 9.5e-103 343.4 0.1 1.2e-102 343.1 0.1 1.1 1 0 0 1 1 1 1 D123 DUF4343 PF14243.4 MSTRG.20593.1_2 - 0.00042 20.4 0.0 0.00076 19.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4343) Reg_prop PF07494.9 MSTRG.20593.1_2 - 0.093 12.9 0.1 0.39 11.0 0.1 2.0 1 0 0 1 1 1 0 Two component regulator propeller Longin PF13774.4 MSTRG.12124.1_1 - 2.5e-23 81.8 1.6 2.6e-23 81.7 0.2 1.8 2 0 0 2 2 2 1 Regulated-SNARE-like domain Synaptobrevin PF00957.19 MSTRG.12124.1_1 - 1.8e-15 56.3 0.4 1.8e-15 56.3 0.4 2.0 2 0 0 2 2 2 1 Synaptobrevin DENN PF02141.19 MSTRG.18447.2_2 - 2.9e-55 187.0 1.4 4.6e-55 186.3 1.4 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.16 MSTRG.18447.2_2 - 2e-09 38.0 0.1 5.6e-09 36.6 0.1 1.8 1 0 0 1 1 1 1 uDENN domain DUF2065 PF09838.7 MSTRG.18447.2_2 - 0.1 12.5 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2065) SR-25 PF10500.7 MSTRG.18447.2_2 - 2 7.8 8.0 3.1 7.2 8.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF2561 PF10812.6 MSTRG.5293.1_1 - 0.11 12.3 0.8 0.39 10.6 0.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) PDZ PF00595.22 MSTRG.11882.3_2 - 2.4e-12 46.9 0.6 4.6e-12 46.0 0.6 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.11882.3_2 - 0.00019 21.5 0.3 0.00034 20.7 0.3 1.4 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.4 MSTRG.11882.3_2 - 0.024 14.5 0.1 0.051 13.5 0.1 1.5 2 0 0 2 2 2 0 Tricorn protease PDZ domain Pkinase PF00069.23 MSTRG.5348.1_1 - 7e-50 169.7 0.0 2.1e-49 168.2 0.0 1.9 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.5348.1_1 - 1.6e-34 119.2 0.0 3.4e-34 118.2 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.27802.2_3 - 1.9e-62 210.9 0.0 4.2e-62 209.8 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain HR1 PF02185.14 MSTRG.27802.2_3 - 1.7e-49 165.6 29.7 2.7e-17 62.5 3.7 3.7 3 0 0 3 3 3 3 Hr1 repeat Pkinase_Tyr PF07714.15 MSTRG.27802.2_3 - 1.8e-39 135.5 0.0 2.9e-39 134.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.22 MSTRG.27802.2_3 - 1.8e-09 38.0 2.0 5e-09 36.6 2.0 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 MSTRG.27802.2_3 - 1.4e-06 27.8 0.0 2.5e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Uds1 PF15456.4 MSTRG.27802.2_3 - 0.0071 16.4 23.9 0.3 11.1 2.4 3.4 3 0 0 3 3 3 2 Up-regulated During Septation Tetraspannin PF00335.18 MSTRG.17587.1_3 - 5e-45 153.8 13.5 8e-45 153.1 13.5 1.3 1 0 0 1 1 1 1 Tetraspanin family NfeD PF01957.16 MSTRG.17587.1_3 - 0.044 14.1 0.5 0.044 14.1 0.5 2.0 2 1 0 2 2 2 0 NfeD-like C-terminal, partner-binding CARD PF00619.19 MSTRG.11837.1_1 - 1.4e-17 63.4 0.0 5.6e-17 61.4 0.0 2.2 1 0 0 1 1 1 1 Caspase recruitment domain PDZ PF00595.22 MSTRG.11837.1_1 - 3.9e-06 27.0 0.0 9.2e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Guanylate_kin PF00625.19 MSTRG.11837.1_1 - 5.5e-06 26.0 0.0 5.5e-06 26.0 0.0 2.5 2 1 0 2 2 2 1 Guanylate kinase Kelch_1 PF01344.23 MSTRG.4258.1_3 - 3.3e-34 116.1 0.3 1.6e-07 30.7 0.0 5.6 5 0 0 5 5 5 5 Kelch motif BTB PF00651.29 MSTRG.4258.1_3 - 9.5e-30 103.0 1.2 2.2e-29 101.8 0.8 1.8 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.13 MSTRG.4258.1_3 - 6.8e-26 90.2 3.0 9.3e-26 89.8 1.7 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_6 PF13964.4 MSTRG.4258.1_3 - 2.4e-18 65.6 1.0 3.2e-05 23.9 0.0 6.1 2 1 4 6 6 6 4 Kelch motif Kelch_3 PF13415.4 MSTRG.4258.1_3 - 1.6e-10 40.8 0.0 0.073 13.2 0.0 5.3 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_4 PF13418.4 MSTRG.4258.1_3 - 8.5e-10 38.3 1.6 0.0023 17.7 0.0 5.0 7 0 0 7 7 7 2 Galactose oxidase, central domain Kelch_5 PF13854.4 MSTRG.4258.1_3 - 6.8e-09 35.4 3.0 0.069 13.0 0.1 6.3 6 0 0 6 6 6 2 Kelch motif Kelch_2 PF07646.13 MSTRG.4258.1_3 - 1.8e-06 27.5 6.8 9.3 6.3 0.0 6.2 5 1 0 5 5 5 2 Kelch motif DUF3342 PF11822.6 MSTRG.4258.1_3 - 0.034 14.2 1.4 0.8 9.8 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) Pkinase_Tyr PF07714.15 MSTRG.2825.1_3 - 3.2e-90 301.8 0.0 4.1e-90 301.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.2825.1_3 - 3.1e-42 144.6 0.0 4.6e-42 144.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 MSTRG.2825.1_3 - 1.2e-26 92.4 0.5 2.6e-26 91.3 0.5 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 MSTRG.2825.1_3 - 8e-19 66.8 1.0 2e-18 65.6 0.3 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 MSTRG.2825.1_3 - 4.1e-13 48.8 0.1 1e-12 47.6 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.2825.1_3 - 3.5e-10 39.3 0.0 9.1e-10 38.0 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 MSTRG.2825.1_3 - 0.065 13.4 0.1 0.12 12.6 0.1 1.4 1 0 0 1 1 1 0 Bacterial SH3 domain zf-H2C2_2 PF13465.4 MSTRG.17547.1_2 - 2.1e-73 239.6 57.0 8.3e-09 35.4 0.5 10.8 11 0 0 11 11 11 10 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.17547.1_2 - 2.6e-44 147.1 77.9 2e-05 24.6 0.3 10.7 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.17547.1_2 - 1.8e-30 102.8 76.8 0.0017 18.9 1.2 11.2 11 0 0 11 11 11 10 C2H2-type zinc finger zf-met PF12874.5 MSTRG.17547.1_2 - 7.1e-16 57.9 71.7 0.0016 18.6 2.1 10.8 11 0 0 11 11 10 8 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.17547.1_2 - 5.2e-11 42.4 32.5 0.036 14.3 0.1 9.9 10 0 0 10 10 10 4 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 MSTRG.17547.1_2 - 3.1e-09 36.9 43.0 0.0047 17.1 0.9 6.7 1 1 7 9 9 9 8 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.4 MSTRG.17547.1_2 - 4.8e-07 29.4 60.0 0.04 13.8 1.1 11.2 10 1 0 10 10 10 4 C2H2-type zinc finger zf-C2H2_2 PF12756.5 MSTRG.17547.1_2 - 0.0011 19.1 41.3 0.3 11.3 3.2 8.5 1 1 6 8 8 8 3 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.4 MSTRG.17547.1_2 - 0.0018 17.8 53.3 0.045 13.4 0.1 10.4 10 0 0 10 10 10 4 C2H2-type zinc-finger domain LIM PF00412.20 MSTRG.17547.1_2 - 0.0043 17.1 41.1 1.7 8.8 1.7 8.6 1 1 9 10 10 10 2 LIM domain BolA PF01722.16 MSTRG.17547.1_2 - 0.0058 16.7 21.7 0.85 9.8 0.9 6.6 1 1 3 5 5 5 2 BolA-like protein zinc_ribbon_15 PF17032.3 MSTRG.17547.1_2 - 0.0087 16.6 30.8 1.2 9.8 0.4 5.9 1 1 5 7 7 7 2 zinc-ribbon family DUF2256 PF10013.7 MSTRG.17547.1_2 - 0.024 14.6 26.8 37 4.4 0.1 9.7 10 0 0 10 10 10 0 Uncharacterized protein conserved in bacteria (DUF2256) C1_2 PF03107.14 MSTRG.17547.1_2 - 0.12 12.6 44.0 3.1 8.0 2.5 9.7 2 2 6 9 9 9 0 C1 domain Elf1 PF05129.11 MSTRG.17547.1_2 - 0.2 11.6 43.1 1.8 8.5 1.7 6.5 1 1 8 9 9 9 0 Transcription elongation factor Elf1 like HTH_18 PF12833.5 MSTRG.17547.1_2 - 0.22 11.7 6.5 34 4.6 0.0 4.9 5 0 0 5 5 5 0 Helix-turn-helix domain zf-Sec23_Sec24 PF04810.13 MSTRG.17547.1_2 - 0.84 9.6 28.5 7.3 6.6 0.7 8.7 9 0 0 9 9 9 0 Sec23/Sec24 zinc finger Yippee-Mis18 PF03226.12 MSTRG.17547.1_2 - 7.4 6.7 34.6 3.2 7.9 2.5 5.7 2 2 1 3 3 3 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF3697 PF12478.6 MSTRG.6158.2_1 - 2.1e-14 53.2 0.7 6.9e-14 51.5 0.1 2.3 2 0 0 2 2 2 1 Ubiquitin-associated protein 2 UBA_4 PF14555.4 MSTRG.6158.2_1 - 0.0036 16.9 0.0 0.0064 16.1 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain DUF1296 PF06972.9 MSTRG.6158.2_1 - 0.099 12.7 0.1 0.18 11.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) CUE PF02845.14 MSTRG.6158.2_1 - 0.17 11.5 0.1 0.32 10.6 0.1 1.5 1 0 0 1 1 1 0 CUE domain Comm PF15957.3 MSTRG.6158.2_1 - 0.34 11.2 1.4 2.7 8.2 0.1 2.7 2 0 0 2 2 2 0 Commissureless OMP_b-brl PF13505.4 MSTRG.6158.2_2 - 0.44 10.5 4.3 0.67 9.9 4.3 1.1 1 0 0 1 1 1 0 Outer membrane protein beta-barrel domain EPL1 PF10513.7 MSTRG.20997.1_3 - 4.1e-36 124.6 3.9 4.2e-35 121.3 0.4 2.6 2 0 0 2 2 2 1 Enhancer of polycomb-like zf-HC5HC2H_2 PF13832.4 MSTRG.20997.1_3 - 4.3e-36 123.3 6.8 4.3e-36 123.3 6.8 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.4 MSTRG.20997.1_3 - 8.3e-26 89.9 5.4 8.3e-26 89.9 5.4 3.3 3 0 0 3 3 3 1 PHD-like zinc-binding domain Bromodomain PF00439.23 MSTRG.20997.1_3 - 2.1e-24 85.2 0.1 4.1e-24 84.3 0.1 1.5 1 0 0 1 1 1 1 Bromodomain PWWP PF00855.15 MSTRG.20997.1_3 - 8.2e-15 54.9 1.2 5.2e-14 52.3 0.0 2.7 2 0 0 2 2 2 1 PWWP domain PHD_2 PF13831.4 MSTRG.20997.1_3 - 1.1e-11 44.0 7.3 1.1e-11 44.0 7.3 2.6 2 0 0 2 2 2 1 PHD-finger PHD PF00628.27 MSTRG.20997.1_3 - 2.8e-06 27.0 27.1 0.00021 21.0 15.1 3.0 2 0 0 2 2 2 2 PHD-finger FYVE_2 PF02318.14 MSTRG.20997.1_3 - 0.008 16.3 5.7 0.008 16.3 5.7 2.3 2 0 0 2 2 2 1 FYVE-type zinc finger AP3D1 PF06375.9 MSTRG.20997.1_3 - 3.4 7.8 14.6 5.2 7.2 2.4 3.5 3 0 0 3 3 3 0 AP-3 complex subunit delta-1 C1_1 PF00130.20 MSTRG.20997.1_3 - 8.9 6.2 21.4 0.56 10.0 7.7 2.9 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) TMEM132D_C PF15706.3 MSTRG.2929.1_3 - 9.7e-37 124.5 0.2 9.2e-36 121.4 0.0 2.2 2 0 0 2 2 2 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term TMEM132 PF16070.3 MSTRG.2929.1_3 - 1.1e-14 54.4 0.0 2.1e-14 53.5 0.0 1.5 1 0 0 1 1 1 1 Transmembrane protein family 132 G-gamma PF00631.20 MSTRG.15579.1_2 - 4.3e-15 55.3 0.0 7.5e-15 54.6 0.0 1.4 1 0 0 1 1 1 1 GGL domain RCC1 PF00415.16 MSTRG.14867.1_2 - 3e-47 158.9 14.2 4.6e-13 49.4 0.1 6.7 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat MORN PF02493.18 MSTRG.14867.1_2 - 4.9e-24 82.6 29.2 1.4e-06 27.7 2.1 8.8 8 0 0 8 8 8 6 MORN repeat RCC1_2 PF13540.4 MSTRG.14867.1_2 - 9e-20 69.8 45.3 3.5e-06 26.6 2.4 8.0 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat VPS9 PF02204.16 MSTRG.14867.1_2 - 7.5e-18 64.5 0.0 1.7e-17 63.4 0.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain PH PF00169.27 MSTRG.14867.1_2 - 0.00011 22.6 0.0 0.00031 21.1 0.0 1.8 1 0 0 1 1 1 1 PH domain DUF3158 PF11358.6 MSTRG.14867.1_2 - 0.12 12.0 0.1 0.27 10.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3158) Dynein_heavy PF03028.13 MSTRG.24829.1_1 - 6.4e-73 246.0 0.0 7e-73 245.9 0.0 1.0 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor HSP90 PF00183.16 MSTRG.22647.4_2 - 7.5e-239 793.7 26.5 1e-238 793.3 26.5 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.24 MSTRG.22647.4_2 - 5.1e-13 49.4 0.0 1.4e-12 48.0 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.4 MSTRG.22647.4_2 - 6.7e-11 42.0 0.0 1.9e-10 40.6 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF977 PF06163.9 MSTRG.22647.4_2 - 0.087 12.6 0.0 0.27 11.0 0.0 1.8 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF977) Pyrid_ox_like PF16242.3 MSTRG.22647.4_3 - 0.072 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase like DUF1170 PF06663.11 MSTRG.17761.1_3 - 1.9e-89 298.9 3.3 1.9e-89 298.9 3.3 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1170) CRIC_ras_sig PF10534.7 MSTRG.17761.1_3 - 1.8e-33 114.4 0.4 9.3e-33 112.1 0.0 2.5 3 0 0 3 3 3 1 Connector enhancer of kinase suppressor of ras SAM_1 PF00536.28 MSTRG.17761.1_3 - 2.4e-18 66.2 1.2 3.6e-18 65.6 0.3 1.8 2 0 0 2 2 1 1 SAM domain (Sterile alpha motif) PH PF00169.27 MSTRG.17761.1_3 - 2.9e-15 56.5 1.5 2.9e-15 56.5 1.5 2.4 2 0 0 2 2 2 1 PH domain SAM_2 PF07647.15 MSTRG.17761.1_3 - 5.3e-13 48.7 0.6 1.2e-12 47.6 0.2 1.8 2 0 0 2 2 1 1 SAM domain (Sterile alpha motif) PDZ PF00595.22 MSTRG.17761.1_3 - 4e-08 33.4 0.0 1.1e-07 31.9 0.0 1.8 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) SAM_PNT PF02198.14 MSTRG.17761.1_3 - 0.00028 20.7 0.1 0.00061 19.6 0.1 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain PH_9 PF15410.4 MSTRG.17761.1_3 - 0.023 14.9 5.3 0.4 10.9 2.7 3.4 2 1 0 2 2 2 0 Pleckstrin homology domain L27 PF02828.14 MSTRG.17761.1_3 - 0.048 13.3 0.7 0.16 11.6 0.7 1.9 1 0 0 1 1 1 0 L27 domain CRISPR_assoc PF08798.9 MSTRG.17761.1_3 - 0.058 13.4 0.2 0.13 12.3 0.2 1.5 1 0 0 1 1 1 0 CRISPR associated protein PDZ_2 PF13180.4 MSTRG.17761.1_3 - 0.17 12.1 0.0 0.48 10.6 0.0 1.7 1 0 0 1 1 1 0 PDZ domain PH_11 PF15413.4 MSTRG.17761.1_3 - 1.3 9.3 9.2 11 6.4 9.2 2.4 1 1 0 1 1 1 0 Pleckstrin homology domain AROS PF15684.3 MSTRG.27399.2_2 - 1.5e-20 73.9 9.4 2e-20 73.5 9.4 1.1 1 0 0 1 1 1 1 Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1 DUF3310 PF11753.6 MSTRG.27399.2_2 - 0.2 11.7 0.2 0.2 11.7 0.2 1.7 2 0 0 2 2 2 0 Protein of unknwon function (DUF3310) DUF2418 PF10332.7 MSTRG.17555.1_3 - 1.3 9.5 4.8 8.9 6.8 0.4 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2418) GYF PF02213.14 MSTRG.2516.1_1 - 2.6e-18 65.4 5.1 6.2e-18 64.1 5.1 1.7 1 0 0 1 1 1 1 GYF domain Ank_4 PF13637.4 MSTRG.704.1_3 - 1.1e-16 60.9 0.4 5.1e-09 36.4 0.4 4.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 MSTRG.704.1_3 - 6.7e-16 58.5 0.2 7.4e-13 48.8 0.2 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.704.1_3 - 1.1e-09 38.3 0.6 5.6e-07 29.6 0.2 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.704.1_3 - 1.8e-08 34.3 2.1 2.8e-05 24.2 0.3 3.6 3 0 0 3 3 3 2 Ankyrin repeat SAM_1 PF00536.28 MSTRG.704.1_3 - 2.7e-08 34.0 0.0 1.1e-07 32.1 0.0 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Ank_3 PF13606.4 MSTRG.704.1_3 - 5.6e-08 32.3 0.5 0.0019 18.4 0.1 3.7 3 0 0 3 3 3 2 Ankyrin repeat SAM_2 PF07647.15 MSTRG.704.1_3 - 0.00014 21.8 0.0 0.00027 20.8 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) FAM75 PF14650.4 MSTRG.704.1_3 - 0.47 9.8 3.8 0.66 9.3 3.8 1.1 1 0 0 1 1 1 0 FAM75 family Histone PF00125.22 MSTRG.4807.1_2 - 9.8e-54 181.2 1.7 1.6e-53 180.5 1.7 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.4 MSTRG.4807.1_2 - 0.0002 21.3 0.0 0.00043 20.2 0.0 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.4 MSTRG.4807.1_2 - 0.0015 18.7 0.0 0.0025 18.0 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.3 MSTRG.4807.1_2 - 0.038 14.5 2.1 0.071 13.6 2.1 1.4 1 0 0 1 1 1 0 PCNA-associated factor BBIP10 PF14777.4 MSTRG.11445.1_2 - 8.7e-30 102.0 10.2 1.4e-29 101.3 10.2 1.3 1 0 0 1 1 1 1 Cilia BBSome complex subunit 10 Apolipoprotein PF01442.16 MSTRG.6121.2_3 - 0.00011 22.0 10.3 0.00026 20.8 10.3 1.5 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.10 MSTRG.6121.2_3 - 0.00083 19.3 2.4 0.0012 18.8 2.4 1.2 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus Cullin PF00888.20 MSTRG.6121.2_3 - 0.0081 14.7 5.8 0.011 14.3 5.8 1.1 1 0 0 1 1 1 1 Cullin family ApoA-II PF04711.11 MSTRG.6121.2_3 - 0.013 15.5 1.0 0.013 15.5 1.0 2.7 2 1 1 3 3 3 0 Apolipoprotein A-II (ApoA-II) TLD PF07534.14 MSTRG.6121.2_3 - 0.035 14.2 0.1 5.8 7.0 0.1 2.2 2 0 0 2 2 2 0 TLD Kdo_hydroxy PF11004.6 MSTRG.6121.2_3 - 0.036 13.2 2.8 0.054 12.6 2.8 1.2 1 0 0 1 1 1 0 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase YfcL PF08891.9 MSTRG.6121.2_3 - 0.044 14.0 0.7 0.044 14.0 0.7 2.4 1 1 1 2 2 2 0 YfcL protein DUF1409 PF07197.10 MSTRG.6121.2_3 - 0.12 12.2 0.0 0.32 10.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1409) DUF883 PF05957.11 MSTRG.6121.2_3 - 0.15 12.5 2.6 0.2 12.1 0.8 1.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Exonuc_VII_L PF02601.13 MSTRG.6121.2_3 - 0.32 10.4 5.0 0.45 9.9 5.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit FUSC PF04632.10 MSTRG.6121.2_3 - 0.71 8.2 5.7 0.9 7.9 5.7 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family FAM184 PF15665.3 MSTRG.6121.2_3 - 1.8 8.1 13.4 2.7 7.6 13.4 1.1 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B DUF4795 PF16043.3 MSTRG.6121.2_3 - 4.9 6.6 12.4 7.7 5.9 12.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) WXG100 PF06013.10 MSTRG.6121.2_3 - 9.7 6.4 17.0 5.2 7.2 7.9 2.7 1 1 1 2 2 2 0 Proteins of 100 residues with WXG GST_N_3 PF13417.4 MSTRG.10794.2_2 - 1.3e-12 47.7 0.0 2.3e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.4 MSTRG.10794.2_2 - 1.1e-11 44.7 0.0 2e-11 43.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 MSTRG.10794.2_2 - 1.5e-10 40.7 0.0 3.8e-10 39.4 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.4 MSTRG.10794.2_2 - 2.6e-10 40.3 0.0 4.4e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.18 MSTRG.10794.2_2 - 1.4e-08 34.8 0.0 2.6e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 MSTRG.10794.2_2 - 2.4e-07 30.7 0.1 4e-07 30.0 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.3 MSTRG.10794.2_2 - 0.0072 16.8 0.0 0.014 15.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain IL8 PF00048.18 MSTRG.24850.1_3 - 1.3e-05 25.1 0.7 6.2e-05 22.9 0.2 2.1 2 0 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like VPR PF00522.16 MSTRG.24850.1_3 - 0.047 13.6 0.0 0.079 12.9 0.0 1.3 1 0 0 1 1 1 0 VPR/VPX protein Pkinase PF00069.23 MSTRG.4921.2_2 - 2.7e-68 230.1 0.0 3.8e-68 229.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 MSTRG.4921.2_2 - 4e-38 129.2 0.0 5.7e-22 77.5 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Pkinase_Tyr PF07714.15 MSTRG.4921.2_2 - 1.8e-34 119.1 0.0 2.7e-34 118.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.4 MSTRG.4921.2_2 - 5.2e-24 84.5 0.1 4.4e-13 49.5 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.4921.2_2 - 4.3e-17 62.1 0.6 1.2e-08 35.0 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.23 MSTRG.4921.2_2 - 4.6e-15 55.4 0.2 7.2e-08 32.4 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin domain fn3 PF00041.19 MSTRG.4921.2_2 - 1.2e-11 44.7 0.1 2.4e-11 43.7 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III domain V-set PF07686.15 MSTRG.4921.2_2 - 8.7e-09 35.4 3.6 0.0052 16.8 0.1 4.8 3 2 0 3 3 3 2 Immunoglobulin V-set domain RIO1 PF01163.20 MSTRG.4921.2_2 - 0.00015 21.3 0.0 0.00028 20.4 0.0 1.3 1 0 0 1 1 1 1 RIO1 family C2-set_2 PF08205.10 MSTRG.4921.2_2 - 0.016 15.1 0.1 0.078 12.9 0.0 2.2 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain FTA2 PF13095.4 MSTRG.4921.2_2 - 0.056 12.9 0.3 2.1 7.8 0.0 2.4 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Y_Y_Y PF07495.11 MSTRG.4921.2_2 - 0.12 12.3 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 Y_Y_Y domain Ig_2 PF13895.4 MSTRG.20869.1_2 - 3.1e-24 85.0 10.9 5.4e-10 39.4 0.0 4.6 3 2 1 4 4 4 3 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.20869.1_2 - 1.2e-21 77.0 15.2 2e-05 25.0 0.0 5.6 5 1 0 5 5 5 4 Immunoglobulin domain V-set PF07686.15 MSTRG.20869.1_2 - 2.6e-12 46.7 15.7 0.01 15.9 0.2 7.2 3 3 3 6 6 6 6 Immunoglobulin V-set domain I-set PF07679.14 MSTRG.20869.1_2 - 6.1e-12 45.3 0.8 0.14 12.1 1.0 6.2 5 1 0 5 5 5 3 Immunoglobulin I-set domain ig PF00047.23 MSTRG.20869.1_2 - 1.4e-07 31.5 15.5 0.57 10.3 0.1 7.0 5 3 0 5 5 5 3 Immunoglobulin domain Izumo-Ig PF16706.3 MSTRG.20869.1_2 - 0.0039 17.1 0.0 9 6.3 0.0 3.7 4 0 0 4 4 4 2 Izumo-like Immunoglobulin domain 6PF2K PF01591.16 MSTRG.13645.2_3 - 9.4e-102 338.9 0.6 1.9e-100 334.6 0.4 2.2 2 0 0 2 2 2 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.20 MSTRG.13645.2_3 - 4.9e-41 140.4 0.0 7.1e-41 139.9 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.4 MSTRG.13645.2_3 - 1.2e-07 31.8 0.0 2.2e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.8 MSTRG.13645.2_3 - 0.033 13.5 0.0 0.05 12.9 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 FAD_binding_3 PF01494.17 MSTRG.14692.1_1 - 4.4e-23 82.0 0.0 6.3e-23 81.5 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.4 MSTRG.14692.1_1 - 7.9e-06 25.9 0.1 1.9e-05 24.6 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SE PF08491.8 MSTRG.14692.1_1 - 5.9e-05 22.1 0.0 0.00074 18.5 0.0 2.1 1 1 0 1 1 1 1 Squalene epoxidase Pyr_redox PF00070.25 MSTRG.14692.1_1 - 0.00015 22.2 0.4 0.00034 21.0 0.3 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 MSTRG.14692.1_1 - 0.00021 20.9 0.0 0.00083 18.9 0.0 1.7 1 1 1 2 2 2 1 FAD dependent oxidoreductase 3HCDH_N PF02737.16 MSTRG.14692.1_1 - 0.00048 19.9 2.2 0.001 18.9 0.1 2.1 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.12 MSTRG.14692.1_1 - 0.00079 18.6 0.1 0.0016 17.7 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.12 MSTRG.14692.1_1 - 0.022 14.2 0.1 0.035 13.6 0.1 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain zf-C3HC4_3 PF13920.4 MSTRG.798.1_1 - 8.9e-13 47.7 12.9 1.6e-12 46.9 12.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 MSTRG.798.1_1 - 1.2e-05 25.0 13.3 2.8e-05 23.8 13.3 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.4 MSTRG.798.1_1 - 0.00036 20.6 14.6 0.0008 19.5 14.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.4 MSTRG.798.1_1 - 0.0073 16.1 12.9 0.016 15.0 12.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.4 MSTRG.798.1_1 - 0.62 9.8 14.7 1.3 8.8 14.7 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.4 MSTRG.798.1_1 - 7 6.3 11.1 16 5.2 11.1 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Voltage_CLC PF00654.18 MSTRG.20088.1_3 - 2.3e-109 365.7 17.5 3.4e-109 365.2 17.5 1.3 1 0 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.26 MSTRG.20088.1_3 - 7.2e-15 55.0 1.4 1.2e-06 28.7 0.1 2.4 2 0 0 2 2 2 2 CBS domain Npa1 PF11707.6 MSTRG.22449.1_1 - 4.1e-37 128.2 0.6 6.5e-37 127.5 0.2 1.5 2 0 0 2 2 2 1 Ribosome 60S biogenesis N-terminal Arfaptin PF06456.11 MSTRG.12617.2_3 - 6.3e-85 284.3 6.4 8.2e-85 283.9 6.4 1.1 1 0 0 1 1 1 1 Arfaptin-like domain ICA69 PF04629.12 MSTRG.12617.2_3 - 2.3e-27 96.8 2.5 4.7e-27 95.8 2.5 1.5 1 0 0 1 1 1 1 Islet cell autoantigen ICA69, C-terminal domain Prefoldin_2 PF01920.18 MSTRG.6354.1_2 - 6.7e-07 29.1 3.4 1.1e-06 28.5 3.4 1.3 1 0 0 1 1 1 1 Prefoldin subunit APC_N_CC PF16689.3 MSTRG.6354.1_2 - 0.5 10.3 4.2 0.95 9.4 1.9 2.3 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain Bcr-Abl_Oligo PF09036.8 MSTRG.6354.1_2 - 8.1 6.4 7.3 5.7 6.9 0.1 3.0 2 1 1 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain Lyase_aromatic PF00221.17 MSTRG.14462.1_3 - 2.9e-196 652.5 0.3 3.4e-196 652.3 0.3 1.0 1 0 0 1 1 1 1 Aromatic amino acid lyase DUF3534 PF12053.6 MSTRG.14462.1_3 - 6.9e-08 32.8 0.0 1.3e-07 31.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3534) DUF2570 PF10828.6 MSTRG.14462.1_3 - 0.083 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) RVT_1 PF00078.25 MSTRG.14567.1_3 - 2.5e-31 108.8 0.0 3.7e-31 108.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MFS_1 PF07690.14 MSTRG.16439.1_2 - 2.8e-28 98.7 28.8 2.8e-28 98.7 28.8 2.6 1 1 2 3 3 3 2 Major Facilitator Superfamily SYS1 PF09801.7 MSTRG.16439.1_2 - 0.13 12.3 7.5 0.24 11.4 5.2 2.7 2 1 0 2 2 2 0 Integral membrane protein S linking to the trans Golgi network Gelsolin PF00626.20 MSTRG.14138.1_2 - 9.2e-101 329.7 0.1 3.3e-20 71.6 0.0 6.3 6 0 0 6 6 6 6 Gelsolin repeat VHP PF02209.17 MSTRG.14138.1_2 - 4.4e-16 58.5 0.1 1.1e-15 57.3 0.1 1.7 1 0 0 1 1 1 1 Villin headpiece domain ANTH PF07651.14 MSTRG.10037.3_1 - 3.9e-55 186.7 0.7 5.3e-55 186.2 0.7 1.2 1 0 0 1 1 1 1 ANTH domain STN1_2 PF09170.8 MSTRG.10037.3_1 - 0.016 15.3 0.8 0.025 14.7 0.8 1.2 1 0 0 1 1 1 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 PAS_11 PF14598.4 MSTRG.10481.2_2 - 1.2e-33 115.4 0.1 1.2e-33 115.4 0.1 3.2 4 0 0 4 4 4 2 PAS domain SRC-1 PF08832.8 MSTRG.10481.2_2 - 9.3e-19 68.1 3.4 9.3e-19 68.1 3.4 3.5 3 0 0 3 3 3 1 Steroid receptor coactivator Nuc_rec_co-act PF08815.8 MSTRG.10481.2_2 - 2.5e-18 65.6 0.8 4.8e-18 64.7 0.8 1.5 1 0 0 1 1 1 1 Nuclear receptor coactivator DUF4927 PF16279.3 MSTRG.10481.2_2 - 2.3e-09 38.0 2.6 8e-09 36.3 2.6 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4927) NCOA_u2 PF16665.3 MSTRG.10481.2_2 - 2.1e-06 27.9 12.4 2.1e-06 27.9 12.4 3.3 3 0 0 3 3 3 1 Unstructured region on nuclear receptor coactivator protein PAS PF00989.23 MSTRG.10481.2_2 - 9e-06 25.5 0.0 3.5e-05 23.6 0.0 1.9 2 0 0 2 2 2 1 PAS fold PAS_3 PF08447.10 MSTRG.10481.2_2 - 0.0011 19.1 0.0 1.2 9.4 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.5 MSTRG.10481.2_2 - 0.0062 16.6 0.0 0.013 15.7 0.0 1.5 1 0 0 1 1 1 1 PAS domain HLH PF00010.24 MSTRG.10481.2_2 - 0.0086 15.9 1.3 0.021 14.6 1.3 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain UQ_con PF00179.24 MSTRG.16553.1_3 - 1.3e-47 160.8 0.0 1.9e-47 160.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme PIEZO PF15917.3 MSTRG.17932.1_1 - 6.3e-91 303.7 2.2 1.4e-90 302.6 2.2 1.6 1 0 0 1 1 1 1 Piezo Piezo_RRas_bdg PF12166.6 MSTRG.17932.1_1 - 4.9e-58 197.2 0.1 7.4e-58 196.6 0.1 1.2 1 0 0 1 1 1 1 Piezo non-specific cation channel, R-Ras-binding domain DUF1279 PF06916.11 MSTRG.17932.1_1 - 0.033 14.6 0.4 0.13 12.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1279) Piezo_RRas_bdg PF12166.6 MSTRG.17932.1_3 - 2.8e-86 290.3 0.0 3.7e-86 289.9 0.0 1.1 1 0 0 1 1 1 1 Piezo non-specific cation channel, R-Ras-binding domain NST1 PF13945.4 MSTRG.1236.1_1 - 0.22 11.5 2.2 0.32 10.9 2.2 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator DUF4657 PF15552.4 MSTRG.1236.1_3 - 2.8e-05 23.7 1.4 2.8e-05 23.7 1.4 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4657) RILP PF11461.6 MSTRG.20895.4_2 - 4e-22 78.0 1.5 7.5e-22 77.2 1.5 1.4 1 0 0 1 1 1 1 Rab interacting lysosomal protein Mucin2_WxxW PF13330.4 MSTRG.27320.1_2 - 3.3e-127 415.5 36.0 2.5e-23 82.6 1.4 6.4 6 0 0 6 6 6 6 Mucin-2 protein WxxW repeating region Zf_RING PF16744.3 MSTRG.27320.1_2 - 7.9e-05 22.6 9.6 0.59 10.2 0.0 5.1 5 0 0 5 5 5 3 KIAA1045 RING finger adh_short PF00106.23 MSTRG.8876.4_2 - 2.6e-35 121.5 0.1 2e-34 118.6 0.1 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 MSTRG.8876.4_2 - 1.8e-24 86.5 0.1 5.5e-24 84.9 0.1 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 MSTRG.8876.4_2 - 4.3e-09 36.4 0.2 6.5e-09 35.8 0.2 1.4 1 1 0 1 1 1 1 KR domain Hpr_kinase_C PF07475.10 MSTRG.8876.4_2 - 0.024 14.1 0.0 0.034 13.6 0.0 1.2 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain Tetraspannin PF00335.18 MSTRG.24270.2_3 - 3.4e-20 72.6 2.4 3.7e-20 72.5 2.4 1.2 1 0 0 1 1 1 1 Tetraspanin family DEAD PF00270.27 MSTRG.7959.1_2 - 3.8e-49 166.7 0.0 1.7e-48 164.6 0.0 1.9 1 1 1 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.7959.1_2 - 4.6e-15 55.8 0.0 1.2e-14 54.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.7959.1_2 - 0.00026 20.9 0.0 0.00081 19.3 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.4 MSTRG.7959.1_2 - 0.066 13.4 0.0 1.7 8.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain HMG_box PF00505.17 MSTRG.21083.1_1 - 1.9e-21 76.1 7.0 6.9e-15 55.1 1.0 2.9 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.8 MSTRG.21083.1_1 - 1.3e-13 51.2 4.0 8.6e-08 32.5 0.2 3.1 3 0 0 3 3 3 2 HMG-box domain DUF2681 PF10883.6 MSTRG.21083.1_3 - 3.8 7.8 6.5 6.8 7.0 6.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) RSN1_7TM PF02714.13 MSTRG.7757.1_1 - 4.5e-60 203.2 20.7 8.4e-60 202.3 20.7 1.5 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.4 MSTRG.7757.1_1 - 1.9e-36 125.8 1.0 3.5e-36 125.0 1.0 1.5 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.4 MSTRG.7757.1_1 - 5.1e-19 68.4 0.0 5.1e-19 68.4 0.0 4.4 4 1 0 4 4 4 1 Late exocytosis, associated with Golgi transport RRM_1 PF00076.20 MSTRG.7757.1_1 - 0.0057 16.3 0.0 3.8 7.3 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transferrin PF00405.15 MSTRG.12242.1_1 - 2.6e-192 638.1 7.4 1.2e-107 359.8 0.6 2.1 2 0 0 2 2 2 2 Transferrin HCO3_cotransp PF00955.19 MSTRG.7888.2_2 - 1.6e-08 33.8 0.2 2e-08 33.4 0.2 1.1 1 0 0 1 1 1 1 HCO3- transporter family Gal-bind_lectin PF00337.20 MSTRG.18289.1_1 - 9.5e-31 106.0 0.0 1.3e-30 105.6 0.0 1.2 1 0 0 1 1 1 1 Galactoside-binding lectin TIG PF01833.22 MSTRG.13082.3_1 - 8.2e-18 64.1 3.0 8.9e-10 38.4 0.5 4.1 4 0 0 4 4 4 2 IPT/TIG domain Pkinase_Tyr PF07714.15 MSTRG.13082.3_3 - 1.2e-90 303.2 0.0 1.7e-90 302.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Sema PF01403.17 MSTRG.13082.3_3 - 2.7e-44 151.5 1.0 4.4e-44 150.8 1.0 1.2 1 0 0 1 1 1 1 Sema domain Pkinase PF00069.23 MSTRG.13082.3_3 - 4e-37 127.9 0.0 6e-37 127.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.4 MSTRG.13082.3_3 - 0.0019 17.4 0.0 0.003 16.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RhoGAP PF00620.25 MSTRG.14971.1_3 - 1.5e-06 28.0 0.0 2.2e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain PDZ PF00595.22 MSTRG.11881.5_3 - 1.1e-130 426.2 23.7 9.3e-19 67.4 0.0 9.3 9 0 0 9 9 9 9 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.11881.5_3 - 6.4e-39 132.0 10.4 4.7e-05 23.5 0.0 9.4 9 0 0 9 9 9 8 PDZ domain MPDZ_u10 PF16667.3 MSTRG.11881.5_3 - 7.6e-14 52.2 5.0 4e-13 49.9 5.0 2.3 1 0 0 1 1 1 1 Unstructured region 10 on multiple PDZ protein Tricorn_PDZ PF14685.4 MSTRG.11881.5_3 - 0.00016 21.5 9.1 10 6.1 0.0 6.9 8 0 0 8 8 8 3 Tricorn protease PDZ domain RINGv PF12906.5 MSTRG.17518.2_2 - 2.5e-14 53.0 10.6 1.2e-13 50.8 10.6 2.3 1 0 0 1 1 1 1 RING-variant domain Glyco_transf_29 PF00777.16 MSTRG.10371.2_1 - 3.1e-71 239.8 0.0 4.2e-71 239.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) AKAP2_C PF15304.4 MSTRG.27500.1_2 - 0.015 14.5 1.9 0.028 13.6 1.9 1.4 1 0 0 1 1 1 0 A-kinase anchor protein 2 C-terminus adh_short PF00106.23 MSTRG.18332.1_2 - 5.6e-28 97.6 0.0 1.3e-27 96.5 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 MSTRG.18332.1_2 - 5.2e-22 78.4 0.0 2.1e-21 76.4 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.4 MSTRG.18332.1_2 - 0.00088 19.1 0.0 0.0014 18.5 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.8 MSTRG.18332.1_2 - 0.0011 18.7 0.0 0.0016 18.3 0.0 1.2 1 0 0 1 1 1 1 KR domain 7tm_1 PF00001.19 MSTRG.13650.1_1 - 8.8e-11 41.4 9.7 8.8e-11 41.4 9.7 1.9 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) TNRC6-PABC_bdg PF16608.3 MSTRG.7956.1_1 - 2.8e-57 194.5 31.7 2.3e-54 185.0 28.4 4.3 3 1 1 4 4 4 2 TNRC6-PABC binding domain Ago_hook PF10427.7 MSTRG.7956.1_1 - 4.9e-05 23.8 33.5 4.9e-05 23.8 33.5 5.9 3 2 1 5 5 5 1 Argonaute hook RRM_1 PF00076.20 MSTRG.7956.1_1 - 0.024 14.3 0.0 0.043 13.5 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DNApol3-delta_C PF09115.8 MSTRG.7956.1_1 - 0.06 13.7 4.8 0.11 12.9 4.8 1.2 1 0 0 1 1 1 0 DNA polymerase III, delta subunit, C terminal RRM_occluded PF16842.3 MSTRG.7956.1_1 - 0.093 12.5 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif CRAL_TRIO PF00650.18 MSTRG.9839.2_3 - 1.7e-07 30.9 0.0 2.6e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.13 MSTRG.9839.2_3 - 0.002 18.1 0.0 0.0038 17.2 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain EELM2 PF15863.3 MSTRG.9839.2_3 - 0.0031 17.5 0.0 0.0056 16.7 0.0 1.3 1 0 0 1 1 1 1 Extended EGL-27 and MTA1 homology domain UBA_4 PF14555.4 MSTRG.9839.2_3 - 0.096 12.4 0.0 0.4 10.4 0.0 2.1 2 1 1 3 3 3 0 UBA-like domain DUF3048 PF11258.6 MSTRG.9839.2_3 - 0.15 11.5 0.4 0.22 11.0 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3048) MARVEL PF01284.21 MSTRG.18411.3_3 - 2e-11 44.0 22.7 2e-11 44.0 22.7 2.0 2 0 0 2 2 2 1 Membrane-associating domain Glyco_transf_29 PF00777.16 MSTRG.791.1_3 - 5.9e-36 124.1 1.3 7.1e-36 123.8 1.3 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) UCH PF00443.27 MSTRG.6035.2_3 - 3.3e-46 157.7 5.3 6.3e-46 156.8 5.3 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 MSTRG.6035.2_3 - 5.6e-27 95.0 3.9 5.6e-27 95.0 3.9 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.10 MSTRG.6035.2_3 - 5e-05 23.7 0.0 0.00058 20.3 0.0 2.9 3 0 0 3 3 3 1 DUSP domain ubiquitin PF00240.21 MSTRG.6035.2_3 - 0.00055 19.5 0.3 0.0019 17.7 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin family DUF4679 PF15728.3 MSTRG.6035.2_3 - 0.035 13.0 0.1 0.069 12.0 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4679) Gifsy-2 PF13856.4 MSTRG.21278.1_3 - 0.18 12.0 0.0 0.27 11.5 0.0 1.2 1 0 0 1 1 1 0 ATP-binding sugar transporter from pro-phage Ank_2 PF12796.5 MSTRG.12920.1_2 - 2.1e-25 89.0 1.3 9.8e-14 51.6 0.2 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.12920.1_2 - 4.2e-18 65.3 2.9 3.6e-10 40.0 0.3 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 MSTRG.12920.1_2 - 4.4e-11 42.7 3.7 2.3e-07 30.9 0.2 3.3 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.12920.1_2 - 6e-11 42.2 2.0 6.8e-06 26.2 0.2 4.0 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.4 MSTRG.12920.1_2 - 3.2e-09 36.2 0.8 0.00048 20.2 0.1 3.9 4 0 0 4 4 4 2 Ankyrin repeat SAM_1 PF00536.28 MSTRG.12920.1_2 - 1.4e-08 34.9 0.1 9.3e-08 32.3 0.0 2.4 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 MSTRG.12920.1_2 - 0.034 14.1 0.0 0.076 13.0 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SR-25 PF10500.7 MSTRG.12920.1_2 - 0.34 10.4 7.4 0.52 9.7 7.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Spp-24 PF07448.9 MSTRG.2260.7_1 - 0.024 14.7 0.3 0.049 13.7 0.3 1.5 1 0 0 1 1 1 0 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Kazal_1 PF00050.19 MSTRG.25784.2_3 - 7.1e-06 25.8 0.6 1.5e-05 24.7 0.6 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.13 MSTRG.25784.2_3 - 0.0022 18.0 0.4 0.0022 18.0 0.4 1.7 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain GST_C PF00043.23 MSTRG.10763.1_3 - 4.6e-05 23.4 0.0 8.2e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 MSTRG.10763.1_3 - 0.0017 18.4 0.0 0.003 17.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 MSTRG.10763.1_3 - 0.018 14.8 0.0 0.038 13.8 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain zf-MYND PF01753.16 MSTRG.18207.1_1 - 1.5e-09 37.7 11.2 2.3e-09 37.0 11.2 1.3 1 0 0 1 1 1 1 MYND finger zf-Mss51 PF13824.4 MSTRG.18207.1_1 - 0.0034 17.3 0.8 0.0049 16.8 0.8 1.3 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 Baculo_p48 PF04878.11 MSTRG.18207.1_1 - 0.091 11.5 1.1 0.11 11.3 1.1 1.1 1 0 0 1 1 1 0 Baculovirus P48 protein Spc7 PF08317.9 MSTRG.23861.1_3 - 8.1e-05 21.5 52.3 0.025 13.3 2.4 4.4 4 0 0 4 4 4 3 Spc7 kinetochore protein SOGA PF11365.6 MSTRG.23861.1_3 - 0.057 14.4 1.4 0.057 14.4 1.4 6.0 2 1 5 7 7 7 0 Protein SOGA VGPC1_C PF16799.3 MSTRG.23861.1_3 - 0.13 12.1 0.1 0.13 12.1 0.1 4.8 4 1 0 4 4 4 0 C-terminal membrane-localisation domain of ion-channel, VCN1 DUF4883 PF16224.3 MSTRG.23861.1_3 - 0.33 11.1 4.7 0.086 13.0 0.6 2.1 2 0 0 2 2 2 0 DOmain of unknown function (DUF4883) DUF1664 PF07889.10 MSTRG.23861.1_3 - 5.6 6.8 37.8 0.81 9.6 0.9 5.9 5 1 1 6 6 6 0 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.7 MSTRG.23861.1_3 - 6.5 6.6 73.5 0.42 10.5 7.9 6.3 3 1 2 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Homeobox PF00046.27 MSTRG.3939.1_3 - 1.5e-20 72.6 4.9 3.3e-20 71.5 4.9 1.6 1 0 0 1 1 1 1 Homeobox domain Pkinase PF00069.23 MSTRG.10210.1_1 - 7.6e-64 215.5 0.0 9.1e-64 215.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.10210.1_1 - 1.1e-31 110.0 0.0 1.4e-31 109.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.22 MSTRG.10210.1_1 - 0.013 16.1 0.0 0.023 15.2 0.0 1.5 1 0 0 1 1 1 0 Protein kinase C terminal domain Seadorna_VP7 PF07387.9 MSTRG.10210.1_1 - 0.095 11.6 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.21 MSTRG.10210.1_1 - 0.1 12.4 0.0 0.27 11.0 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.4 MSTRG.10210.1_1 - 0.13 11.4 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Ribosomal_S27e PF01667.15 MSTRG.23580.1_3 - 1.7e-23 81.9 6.0 1.7e-23 81.9 6.0 2.0 2 0 0 2 2 2 1 Ribosomal protein S27 SH3_9 PF14604.4 MSTRG.9315.3_2 - 6.7e-17 61.0 2.0 1.2e-13 50.6 0.1 2.8 3 0 0 3 3 3 2 Variant SH3 domain SH3_1 PF00018.26 MSTRG.9315.3_2 - 1.1e-14 53.6 0.3 2.7e-14 52.3 0.1 1.8 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 MSTRG.9315.3_2 - 1.2e-14 53.6 0.2 2.1e-06 27.2 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain C1_1 PF00130.20 MSTRG.9315.3_2 - 1.4e-06 27.9 14.4 1.4e-06 27.9 14.4 2.1 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) STAC2_u1 PF16664.3 MSTRG.9315.3_2 - 0.0051 17.1 1.1 0.0051 17.1 1.1 1.9 2 1 0 2 2 2 1 Unstructured on SH3 and cysteine-rich domain-containing protein 2 C1_2 PF03107.14 MSTRG.9315.3_2 - 0.034 14.3 8.4 0.1 12.8 8.4 1.8 1 0 0 1 1 1 0 C1 domain PHD PF00628.27 MSTRG.9315.3_2 - 1.5 8.6 11.2 0.33 10.8 7.4 1.9 2 0 0 2 2 2 0 PHD-finger DUF1917 PF08939.8 MSTRG.25980.1_1 - 1.7e-15 57.5 0.0 2.6e-15 56.9 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1917) PX PF00787.22 MSTRG.5266.1_1 - 5.5e-21 74.5 1.4 5.5e-21 74.5 1.4 2.0 2 0 0 2 2 2 1 PX domain FAM92 PF06730.9 MSTRG.5266.1_1 - 0.00013 21.4 0.1 0.00027 20.3 0.1 1.5 1 0 0 1 1 1 1 FAM92 protein DUF3896 PF13035.4 MSTRG.5266.1_1 - 0.14 12.2 1.7 2.2 8.4 0.4 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3896) PDZ PF00595.22 MSTRG.13646.4_3 - 3e-70 232.5 8.8 5.5e-13 48.9 0.1 6.4 6 0 0 6 6 6 6 PDZ domain (Also known as DHR or GLGF) MAGI_u5 PF16666.3 MSTRG.13646.4_3 - 2.1e-36 124.9 9.8 2.1e-36 124.9 9.8 4.1 5 0 0 5 5 5 1 Unstructured region on MAGI PDZ_2 PF13180.4 MSTRG.13646.4_3 - 1e-27 96.1 1.3 0.00016 21.8 0.0 6.0 6 0 0 6 6 6 5 PDZ domain MAGI_u1 PF16663.3 MSTRG.13646.4_3 - 5.7e-19 67.7 0.9 5.7e-19 67.7 0.9 2.8 3 0 0 3 3 3 1 Unstructured region on MAGI WW PF00397.24 MSTRG.13646.4_3 - 4.7e-18 64.7 5.6 7.2e-10 38.5 0.3 2.7 2 0 0 2 2 2 2 WW domain Guanylate_kin PF00625.19 MSTRG.13646.4_3 - 9.8e-11 41.5 0.0 1.9e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Guanylate kinase Tricorn_PDZ PF14685.4 MSTRG.13646.4_3 - 3.9e-06 26.6 8.8 1.7 8.5 0.0 5.9 6 0 0 6 6 6 3 Tricorn protease PDZ domain DUF1681 PF07933.12 MSTRG.13942.1_2 - 6.7e-58 194.5 0.0 9e-58 194.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) zf-C2H2_2 PF12756.5 MSTRG.9974.6_3 - 0.022 14.9 0.6 0.022 14.9 0.6 3.2 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.6 MSTRG.9974.6_3 - 3 8.1 10.1 0.43 10.8 4.2 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Ribosomal_L18A PF01775.15 MSTRG.24214.1_3 - 8.5e-55 183.9 0.0 1.1e-54 183.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A CNRIP1 PF15043.4 MSTRG.18309.1_2 - 1.6e-23 82.8 0.0 2e-23 82.6 0.0 1.1 1 0 0 1 1 1 1 CB1 cannabinoid receptor-interacting protein 1 Calsarcin PF05556.9 MSTRG.27788.1_2 - 3.9e-06 26.4 6.1 0.0017 17.7 0.4 3.1 3 1 0 3 3 3 2 Calcineurin-binding protein (Calsarcin) LSM PF01423.20 MSTRG.1073.1_3 - 7.4e-19 67.1 0.6 1.1e-18 66.6 0.6 1.2 1 0 0 1 1 1 1 LSM domain Metallophos_2 PF12850.5 MSTRG.1261.2_3 - 3e-21 76.2 0.0 3.8e-21 75.9 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.26 MSTRG.1261.2_3 - 0.00018 21.9 0.8 0.13 12.6 0.8 2.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase RmlD_sub_bind PF04321.15 MSTRG.20687.5_3 - 8.8e-70 234.9 0.0 1.1e-69 234.6 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.19 MSTRG.20687.5_3 - 2.3e-26 92.6 0.0 3.1e-26 92.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 MSTRG.20687.5_3 - 6.7e-14 51.9 0.0 5.8e-13 48.8 0.0 2.1 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.13 MSTRG.20687.5_3 - 1.6e-09 37.2 0.7 2.1e-07 30.3 0.1 2.7 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.10 MSTRG.20687.5_3 - 5.5e-05 22.3 0.4 0.0039 16.3 0.0 2.5 2 1 0 2 2 2 1 Male sterility protein 3Beta_HSD PF01073.17 MSTRG.20687.5_3 - 0.00099 18.0 0.1 0.029 13.2 0.1 2.2 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.23 MSTRG.20687.5_3 - 0.01 15.1 0.6 0.066 12.5 0.6 2.0 1 1 0 1 1 1 0 short chain dehydrogenase KR PF08659.8 MSTRG.20687.5_3 - 0.043 13.6 1.9 7 6.4 0.1 3.0 2 1 1 3 3 3 0 KR domain NAD_binding_10 PF13460.4 MSTRG.20687.5_3 - 0.05 13.4 0.1 0.2 11.4 0.1 1.9 2 1 0 2 2 2 0 NAD(P)H-binding DUF3657 PF12394.6 MSTRG.7694.2_1 - 1.6e-17 63.7 0.8 7.8e-17 61.4 0.3 2.4 2 0 0 2 2 2 1 Protein FAM135 Wound_ind PF08186.9 MSTRG.7694.2_2 - 0.14 12.4 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 Wound-inducible basic protein family FAM72 PF14976.4 MSTRG.13866.1_3 - 6.4e-77 256.5 6.1 9.3e-77 256.0 6.1 1.2 1 0 0 1 1 1 1 FAM72 protein Ribul_P_3_epim PF00834.17 MSTRG.22963.1_3 - 2.2e-66 222.9 0.0 2.6e-66 222.7 0.0 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.17 MSTRG.22963.1_3 - 0.049 13.3 0.0 0.2 11.3 0.0 1.9 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain TPR_1 PF00515.26 MSTRG.24974.1_3 - 4.2e-07 29.4 0.4 6.5e-05 22.4 0.3 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.24974.1_3 - 5.6e-07 29.1 1.6 0.0009 19.0 0.4 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.24974.1_3 - 8.3e-06 25.9 0.4 2.3e-05 24.4 0.4 1.7 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.24974.1_3 - 4e-05 23.2 0.9 0.029 14.2 0.2 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.24974.1_3 - 0.00053 19.9 1.3 0.64 10.3 0.3 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.24974.1_3 - 0.00076 19.2 0.2 0.088 12.6 0.1 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.24974.1_3 - 0.015 15.9 0.1 5.7 7.9 0.1 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 MSTRG.24974.1_3 - 0.023 14.6 0.0 7.5 6.6 0.0 2.2 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat MAS20 PF02064.13 MSTRG.24974.1_3 - 0.079 12.9 0.0 0.09 12.7 0.0 1.1 1 0 0 1 1 1 0 MAS20 protein import receptor TUDOR PF00567.22 MSTRG.11469.2_1 - 1.2e-16 60.8 0.1 2.1e-16 59.9 0.0 1.4 2 0 0 2 2 2 1 Tudor domain WD40 PF00400.30 MSTRG.9993.1_1 - 0.003 18.2 1.1 0.092 13.5 0.8 2.6 2 0 0 2 2 2 1 WD domain, G-beta repeat WD40 PF00400.30 MSTRG.9993.1_3 - 0.0041 17.8 0.4 1.8 9.5 0.0 3.0 3 0 0 3 3 3 2 WD domain, G-beta repeat DUF4505 PF14956.4 MSTRG.1805.2_1 - 3e-53 180.1 0.0 4.2e-53 179.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4505) DUF4505 PF14956.4 MSTRG.1805.2_2 - 3.8e-22 78.7 0.2 5.9e-22 78.1 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4505) UPF0556 PF10572.7 MSTRG.1805.2_2 - 0.011 15.1 0.1 0.016 14.6 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0556 Kelch_1 PF01344.23 MSTRG.703.1_1 - 3.1e-64 212.2 15.5 1.2e-15 56.6 0.1 6.7 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 MSTRG.703.1_1 - 6e-49 162.7 2.4 7.9e-10 38.5 0.0 6.4 4 1 2 6 6 6 6 Kelch motif BACK PF07707.13 MSTRG.703.1_1 - 1.7e-31 108.3 1.4 1.7e-31 108.3 1.4 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_3 PF13415.4 MSTRG.703.1_1 - 2.4e-31 107.3 6.6 1.7e-06 28.0 0.1 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain BTB PF00651.29 MSTRG.703.1_1 - 4.9e-30 103.9 0.6 8.4e-30 103.1 0.6 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_4 PF13418.4 MSTRG.703.1_1 - 3.8e-27 93.8 1.0 0.00017 21.3 0.0 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.13 MSTRG.703.1_1 - 1.5e-26 91.1 5.5 6.3e-09 35.3 0.0 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_5 PF13854.4 MSTRG.703.1_1 - 4.8e-19 67.8 2.3 0.00032 20.5 0.0 5.5 5 0 0 5 5 5 4 Kelch motif Glyoxal_oxid_N PF07250.9 MSTRG.703.1_1 - 0.087 11.8 0.2 0.7 8.9 0.1 2.2 2 1 1 3 3 3 0 Glyoxal oxidase N-terminus RCC1 PF00415.16 MSTRG.26109.4_1 - 4.1e-45 152.0 18.8 2.9e-08 34.1 0.3 6.4 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 MSTRG.26109.4_1 - 8.1e-19 66.8 27.7 5.4e-09 35.5 2.2 5.7 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat UPF0449 PF15136.4 MSTRG.24348.1_3 - 1.3e-21 76.8 0.0 2.3e-21 76.0 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised protein family UPF0449 zf-C3HC4_3 PF13920.4 MSTRG.9964.1_1 - 5.1e-05 22.9 12.0 5.1e-05 22.9 12.0 3.2 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-TRAF PF02176.16 MSTRG.9964.1_1 - 0.0004 20.9 3.2 0.0004 20.9 3.2 2.9 2 1 1 3 3 3 1 TRAF-type zinc finger Sina PF03145.14 MSTRG.9964.1_1 - 0.0008 19.3 4.3 0.0008 19.3 4.3 1.9 1 1 1 2 2 2 1 Seven in absentia protein family zf-RING_4 PF14570.4 MSTRG.9964.1_1 - 0.005 16.4 10.0 0.021 14.4 10.0 2.1 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Peptidase_A17 PF05380.11 MSTRG.18769.1_2 - 0.00033 20.6 0.0 0.0005 20.0 0.0 1.3 1 0 0 1 1 1 1 Pao retrotransposon peptidase Fzo_mitofusin PF04799.11 MSTRG.18769.1_2 - 0.03 13.7 0.0 0.041 13.3 0.0 1.2 1 0 0 1 1 1 0 fzo-like conserved region Ras PF00071.20 MSTRG.2701.1_1 - 2.2e-56 189.8 0.0 3e-56 189.4 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.2701.1_1 - 4.5e-22 78.4 0.0 7.3e-22 77.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.2701.1_1 - 5.8e-09 35.5 0.0 1.1e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 MSTRG.2701.1_1 - 0.0028 17.1 0.0 0.0047 16.3 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Ndr PF03096.12 MSTRG.13112.1_2 - 3.6e-119 396.5 0.0 4.6e-119 396.2 0.0 1.1 1 0 0 1 1 1 1 Ndr family Abhydrolase_1 PF00561.18 MSTRG.13112.1_2 - 0.00099 18.7 0.0 0.031 13.8 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 MSTRG.13112.1_2 - 0.0029 18.1 0.0 0.0043 17.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Cyclin_N PF00134.21 MSTRG.1553.1_2 - 5.3e-23 81.1 0.7 2.5e-20 72.4 0.1 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain DUF572 PF04502.11 MSTRG.1553.1_2 - 0.019 14.4 2.8 0.032 13.6 2.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) WTF PF03303.11 MSTRG.15165.1_2 - 0.18 11.4 2.9 0.23 11.0 2.9 1.1 1 0 0 1 1 1 0 WTF protein BAR_3_WASP_bdg PF10456.7 MSTRG.8328.4_3 - 5.3e-116 386.0 4.1 6.9e-116 385.6 4.1 1.1 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein PX PF00787.22 MSTRG.8328.4_3 - 1.4e-09 37.8 0.0 2.8e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 PX domain SH3_1 PF00018.26 MSTRG.8328.4_3 - 5.9e-09 35.3 0.0 1.5e-08 33.9 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.8328.4_3 - 3.4e-08 32.9 0.0 7.2e-08 31.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 MSTRG.8328.4_3 - 1.7e-07 30.8 0.0 7.7e-07 28.7 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain Vps5 PF09325.8 MSTRG.8328.4_3 - 0.00018 21.0 0.6 0.11 11.9 0.2 2.2 1 1 0 2 2 2 2 Vps5 C terminal like zf-C2H2_2 PF12756.5 MSTRG.25468.1_1 - 2.9e-40 136.5 23.4 3.6e-22 78.5 5.4 3.7 4 0 0 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.4 MSTRG.25468.1_1 - 4.8e-07 29.9 24.4 0.0027 18.3 0.4 6.4 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.25468.1_1 - 0.00048 20.2 2.2 0.00048 20.2 2.2 3.8 4 1 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.24 MSTRG.25468.1_1 - 0.00048 20.3 1.2 0.00048 20.3 1.2 4.8 5 0 0 5 5 5 1 Zinc finger, C2H2 type zf-BED PF02892.13 MSTRG.25468.1_1 - 0.0006 19.7 13.7 0.087 12.8 0.8 5.0 5 0 0 5 5 5 2 BED zinc finger zf-met PF12874.5 MSTRG.25468.1_1 - 0.09 13.1 5.7 0.049 13.9 1.2 3.0 2 0 0 2 2 2 0 Zinc-finger of C2H2 type PyrI_C PF02748.13 MSTRG.25468.1_1 - 0.97 9.3 8.6 0.69 9.7 0.8 3.8 4 0 0 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain CDI PF02234.17 MSTRG.17571.1_3 - 2.5e-17 62.7 1.9 5.6e-17 61.6 1.9 1.7 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor Microtub_bd PF16796.3 MSTRG.17571.1_3 - 0.065 13.1 0.0 0.097 12.5 0.0 1.3 1 0 0 1 1 1 0 Microtubule binding ASH PF15780.3 MSTRG.13460.1_2 - 3.2e-13 49.6 0.0 0.018 15.1 0.0 7.1 7 1 0 7 7 7 3 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Motile_Sperm PF00635.24 MSTRG.13460.1_2 - 2.5e-05 23.9 0.0 0.016 14.9 0.0 3.6 3 0 0 3 3 3 2 MSP (Major sperm protein) domain MYCBPAP PF14646.4 MSTRG.13460.1_2 - 0.0007 18.5 0.0 0.01 14.7 0.0 2.8 3 0 0 3 3 3 1 MYCBP-associated protein family CH PF00307.29 MSTRG.20614.1_2 - 1.1e-10 41.5 0.0 1.6e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain Guanylate_cyc PF00211.18 MSTRG.8126.1_3 - 2.9e-120 398.4 0.2 9.4e-62 207.8 0.1 2.7 3 0 0 3 3 3 2 Adenylate and Guanylate cyclase catalytic domain AC_N PF16214.3 MSTRG.8126.1_3 - 3.1e-14 52.8 7.9 3.1e-14 52.8 7.9 3.4 3 1 1 4 4 4 1 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF1053 PF06327.12 MSTRG.8126.1_3 - 0.00013 22.3 0.1 0.00013 22.3 0.1 2.1 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1053) Glyco_hydro_47 PF01532.18 MSTRG.18095.1_1 - 7.7e-33 113.9 0.0 8.9e-33 113.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DUF4051 PF13260.4 MSTRG.18095.1_1 - 0.059 13.0 0.3 0.12 12.1 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4051) C1q PF00386.19 MSTRG.348.1_2 - 2.4e-21 76.1 0.1 3.6e-21 75.5 0.1 1.2 1 0 0 1 1 1 1 C1q domain PRIMA1 PF16101.3 MSTRG.348.1_2 - 0.061 13.2 6.3 0.11 12.5 6.3 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Mito_fiss_reg PF05308.9 MSTRG.348.1_2 - 2.2 8.2 6.5 3.2 7.6 6.5 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.17 MSTRG.348.1_2 - 7.2 5.9 8.3 10 5.3 8.3 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Tankyrase_bdg_C PF15327.4 MSTRG.2982.2_1 - 4.3e-48 163.8 7.7 4.3e-48 163.8 7.7 2.0 2 0 0 2 2 2 1 Tankyrase binding protein C terminal domain 7tm_2 PF00002.22 MSTRG.1765.1_1 - 1.7e-94 315.6 15.4 2.5e-94 315.0 15.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 MSTRG.1765.1_1 - 3.2e-05 24.0 0.1 3.2e-05 24.0 0.1 2.2 2 0 0 2 2 2 1 Hormone receptor domain DUF3694 PF12473.6 MSTRG.5366.2_1 - 2.3e-27 96.4 0.0 5.4e-27 95.2 0.0 1.7 1 0 0 1 1 1 1 Kinesin protein CAP_GLY PF01302.23 MSTRG.5366.2_1 - 5.6e-23 80.6 0.2 1e-22 79.8 0.2 1.4 1 0 0 1 1 1 1 CAP-Gly domain KIF1B PF12423.6 MSTRG.5366.2_1 - 3.8e-05 24.0 1.9 8.2e-05 22.9 0.0 2.3 2 0 0 2 2 2 1 Kinesin protein 1B DUF3585 PF12130.6 MSTRG.5366.2_1 - 0.02 14.9 4.3 0.046 13.7 4.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3585) Tetraspannin PF00335.18 MSTRG.7987.4_2 - 1.9e-26 93.1 17.4 3e-26 92.4 17.4 1.3 1 0 0 1 1 1 1 Tetraspanin family AC_N PF16214.3 MSTRG.7987.4_2 - 2.2 7.2 5.3 3.2 6.7 5.3 1.2 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region BAH PF01426.16 MSTRG.11824.2_1 - 4.3e-09 36.1 0.0 4.2e-08 32.9 0.0 2.4 2 1 0 2 2 2 1 BAH domain DUF4537 PF15057.4 MSTRG.11824.2_1 - 0.00028 20.7 0.0 0.00056 19.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) Mem_trans PF03547.16 MSTRG.11824.2_1 - 0.3 9.3 0.6 0.42 8.8 0.6 1.2 1 0 0 1 1 1 0 Membrane transport protein Zip PF02535.20 MSTRG.8872.1_3 - 4e-33 114.9 29.5 1.3e-25 90.2 15.2 3.0 1 1 1 2 2 2 2 ZIP Zinc transporter BTB PF00651.29 MSTRG.4100.1_1 - 3.9e-13 49.5 0.0 5.5e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain Mob1_phocein PF03637.15 MSTRG.26532.1_3 - 9.8e-33 113.4 0.7 1.7e-32 112.6 0.7 1.4 1 0 0 1 1 1 1 Mob1/phocein family F-box-like PF12937.5 MSTRG.26532.1_3 - 0.034 13.9 0.2 2.2 8.1 0.0 2.8 2 0 0 2 2 2 0 F-box-like TFIIA PF03153.11 MSTRG.15869.5_2 - 0.0013 18.7 9.5 0.0013 18.7 9.5 1.8 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit DUF3437 PF11919.6 MSTRG.15869.5_2 - 0.016 15.0 0.6 2.3 8.1 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) Sporozoite_P67 PF05642.9 MSTRG.15869.5_2 - 0.03 12.3 4.1 0.053 11.5 4.1 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PilJ PF13675.4 MSTRG.15869.5_2 - 0.03 14.2 2.5 1.2 9.1 0.1 2.6 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF1510 PF07423.9 MSTRG.15869.5_2 - 0.43 9.9 14.8 1.2 8.3 14.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Merozoite_SPAM PF07133.9 MSTRG.15869.5_2 - 0.52 10.2 29.4 0.12 12.2 25.6 1.8 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) Drc1-Sld2 PF11719.6 MSTRG.15869.5_2 - 2.1 7.6 37.2 0.045 13.2 2.9 3.4 2 1 0 3 3 3 0 DNA replication and checkpoint protein Occludin_ELL PF07303.11 MSTRG.15869.5_2 - 9.7 6.8 12.3 1.3 9.6 0.2 3.7 3 0 0 3 3 3 0 Occludin homology domain Ank_5 PF13857.4 MSTRG.6758.1_3 - 1.2e-13 50.8 0.7 4.6e-08 33.1 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 MSTRG.6758.1_3 - 7.2e-13 48.8 0.3 1.9e-05 25.0 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 MSTRG.6758.1_3 - 4.2e-12 45.8 0.2 1.8e-06 28.0 0.1 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.4 MSTRG.6758.1_3 - 2.4e-10 40.6 0.1 0.0002 21.8 0.0 3.6 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.6758.1_3 - 1.1e-09 37.6 0.2 1.8e-05 24.6 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat zf-C4pol PF14260.4 MSTRG.6758.1_3 - 0.47 10.8 5.9 9.8 6.6 0.9 2.6 2 0 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta DZR PF12773.5 MSTRG.6758.1_3 - 0.91 9.5 5.8 0.68 9.9 0.9 2.7 2 0 0 2 2 2 0 Double zinc ribbon Pkinase_Tyr PF07714.15 MSTRG.25978.2_2 - 4.5e-64 216.1 0.0 6e-64 215.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.25978.2_2 - 6.8e-59 199.2 0.0 1.1e-58 198.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH3_2 PF07653.15 MSTRG.25978.2_2 - 5.9e-12 45.0 0.0 1.3e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.25978.2_2 - 3.2e-11 42.5 0.0 5.8e-11 41.7 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.25978.2_2 - 1.4e-10 40.7 0.1 2.6e-10 39.8 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF3552 PF12072.6 MSTRG.25978.2_2 - 0.69 9.2 16.2 1.1 8.5 16.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) AIG1 PF04548.14 MSTRG.19823.1_2 - 6.1e-101 336.0 0.0 1.4e-36 125.7 0.0 3.3 3 0 0 3 3 3 3 AIG1 family MMR_HSR1 PF01926.21 MSTRG.19823.1_2 - 8.6e-14 51.5 0.0 0.0015 18.5 0.0 4.2 4 1 0 4 4 3 3 50S ribosome-binding GTPase Dynamin_N PF00350.21 MSTRG.19823.1_2 - 3.1e-06 27.2 3.1 4.5 7.2 0.0 6.0 4 2 1 5 5 5 2 Dynamin family DUF258 PF03193.14 MSTRG.19823.1_2 - 9.8e-05 22.2 0.2 0.7 9.6 0.0 4.2 5 0 0 5 5 5 2 Protein of unknown function, DUF258 FtsK_SpoIIIE PF01580.16 MSTRG.19823.1_2 - 0.00011 21.5 0.3 4.3 6.5 0.0 3.8 4 0 0 4 4 4 2 FtsK/SpoIIIE family FeoB_N PF02421.16 MSTRG.19823.1_2 - 0.0005 19.5 0.0 0.31 10.4 0.0 3.4 3 0 0 3 3 3 1 Ferrous iron transport protein B Arf PF00025.19 MSTRG.19823.1_2 - 0.0014 18.0 0.0 0.016 14.5 0.0 2.5 2 0 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.11 MSTRG.19823.1_2 - 0.0016 18.5 0.3 17 5.5 0.1 3.7 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.7 MSTRG.19823.1_2 - 0.0075 15.9 0.0 13 5.4 0.0 3.7 4 0 0 4 4 4 0 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.8 MSTRG.19823.1_2 - 0.02 14.2 3.0 0.25 10.6 0.0 3.7 4 0 0 4 4 4 0 Signal recognition particle receptor beta subunit tRNA-synt_1c PF00749.19 MSTRG.19823.1_2 - 0.023 13.4 0.5 4 6.1 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain ABC_tran PF00005.25 MSTRG.19823.1_2 - 0.032 14.6 1.6 2 8.8 0.2 3.8 2 1 0 3 3 3 0 ABC transporter AAA_14 PF13173.4 MSTRG.19823.1_2 - 0.045 13.7 5.4 5.7 6.9 0.0 4.7 5 1 0 5 5 5 0 AAA domain Gtr1_RagA PF04670.10 MSTRG.19823.1_2 - 0.05 12.8 6.8 4.4 6.4 0.0 4.7 5 1 0 5 5 5 0 Gtr1/RagA G protein conserved region AAA_24 PF13479.4 MSTRG.19823.1_2 - 0.061 12.9 0.4 8.6 5.9 0.0 3.8 4 1 0 4 4 4 0 AAA domain G-alpha PF00503.18 MSTRG.19823.1_2 - 0.13 11.3 4.9 0.61 9.0 0.1 3.6 3 1 1 4 4 4 0 G-protein alpha subunit Pkinase PF00069.23 MSTRG.15466.2_1 - 7.2e-61 205.7 0.0 1.5e-60 204.6 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.15466.2_1 - 2.4e-34 118.7 0.0 5.3e-34 117.5 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Vir_act_alpha_C PF10400.7 MSTRG.15466.2_1 - 0.2 12.2 6.7 0.68 10.5 0.8 2.8 2 0 0 2 2 2 0 Virulence activator alpha C-term BID PF06393.9 MSTRG.22200.1_1 - 6.1e-13 48.6 0.2 1.3e-12 47.5 0.2 1.4 1 1 0 1 1 1 1 BH3 interacting domain (BID) zf-DBF PF07535.10 MSTRG.20764.1_1 - 2.7e-12 46.4 0.1 5.6e-12 45.4 0.1 1.6 1 0 0 1 1 1 1 DBF zinc finger BRCT PF00533.24 MSTRG.20764.1_1 - 1.3e-05 25.4 0.1 3.2e-05 24.1 0.0 1.7 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.3 MSTRG.20764.1_1 - 0.042 14.1 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain T-box PF00907.20 MSTRG.1578.1_2 - 9e-65 218.2 0.0 1.6e-64 217.4 0.0 1.5 1 0 0 1 1 1 1 T-box DUF4801 PF16059.3 MSTRG.1578.1_2 - 9e-10 38.3 8.5 9e-10 38.3 8.5 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4801) HLH PF00010.24 MSTRG.1578.1_2 - 0.15 11.9 0.3 0.37 10.7 0.3 1.8 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain DUF4485 PF14846.4 MSTRG.1578.1_2 - 0.21 11.5 1.1 0.56 10.2 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4485) tRNA-synt_1e PF01406.17 MSTRG.6258.1_2 - 1.3e-108 362.8 0.0 1.8e-108 362.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.9 MSTRG.6258.1_2 - 1.5e-06 27.1 0.4 0.025 13.2 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (M) DALR_2 PF09190.9 MSTRG.6258.1_2 - 0.00058 20.2 0.1 0.0021 18.4 0.1 1.9 2 0 0 2 2 2 1 DALR domain tRNA-synt_1 PF00133.20 MSTRG.6258.1_2 - 0.0028 15.8 0.0 0.0043 15.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Ins_allergen_rp PF06757.11 MSTRG.6258.1_2 - 0.0044 16.9 0.0 0.0094 15.8 0.0 1.6 1 1 0 1 1 1 1 Insect allergen related repeat, nitrile-specifier detoxification RasGAP PF00616.17 MSTRG.12260.1_3 - 3.2e-25 88.9 0.4 1.7e-16 60.4 0.1 2.4 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.28 MSTRG.12260.1_3 - 2.3e-10 40.6 0.0 6.2e-10 39.2 0.0 1.8 1 0 0 1 1 1 1 C2 domain RhoGEF PF00621.18 MSTRG.10842.1_1 - 1.6e-39 135.9 1.1 2.9e-39 135.1 0.6 1.7 2 0 0 2 2 2 1 RhoGEF domain SH3-RhoG_link PF16609.3 MSTRG.10842.1_1 - 2e-38 132.5 6.8 2e-38 132.5 6.8 2.9 2 1 1 3 3 3 1 SH3-RhoGEF linking unstructured region PH PF00169.27 MSTRG.10842.1_1 - 5.2e-05 23.6 0.0 0.00026 21.3 0.0 2.3 1 0 0 1 1 1 1 PH domain PH_10 PF15411.4 MSTRG.10842.1_1 - 0.05 13.7 3.4 0.05 13.7 0.1 2.8 3 1 0 3 3 3 0 Pleckstrin homology domain Chromo PF00385.22 MSTRG.26829.1_3 - 1.6e-08 34.2 0.1 2.4e-08 33.6 0.1 1.3 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.4 MSTRG.26829.1_3 - 0.013 15.5 0.2 0.026 14.5 0.2 1.5 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 LLGL PF08366.11 MSTRG.8904.1_2 - 4.3e-32 110.4 0.0 9.5e-32 109.3 0.0 1.6 1 0 0 1 1 1 1 LLGL2 ANAPC4_WD40 PF12894.5 MSTRG.8904.1_2 - 1.8e-07 31.2 2.0 1.3 9.3 0.1 5.2 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Lgl_C PF08596.8 MSTRG.8904.1_2 - 3.7e-06 25.8 0.0 5.3e-05 22.0 0.0 2.5 3 0 0 3 3 3 1 Lethal giant larvae(Lgl) like, C-terminal WD40 PF00400.30 MSTRG.8904.1_2 - 4.3e-05 24.1 6.8 0.39 11.5 0.2 6.0 5 1 0 5 5 5 2 WD domain, G-beta repeat Synaptobrevin PF00957.19 MSTRG.8904.1_2 - 0.0062 16.2 1.6 0.0068 16.0 0.0 1.8 2 0 0 2 2 2 1 Synaptobrevin RAB3GAP2_N PF14655.4 MSTRG.8904.1_2 - 0.016 14.3 0.0 5.4 6.0 0.0 2.3 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Voldacs PF03517.11 MSTRG.27064.1_1 - 2.7e-35 121.3 0.7 4.2e-35 120.7 0.7 1.3 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling PH_TFIIH PF08567.9 MSTRG.27064.1_1 - 0.13 12.4 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 TFIIH p62 subunit, N-terminal domain BUD22 PF09073.8 MSTRG.27064.1_1 - 9.2 5.4 8.8 13 4.9 8.8 1.1 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.10 MSTRG.27064.1_1 - 9.6 5.4 7.9 13 4.9 7.9 1.1 1 0 0 1 1 1 0 SDA1 Pkinase PF00069.23 MSTRG.12942.2_1 - 1.4e-71 240.8 0.0 1.9e-71 240.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.12942.2_1 - 2.6e-33 115.3 0.0 3.8e-33 114.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.12942.2_1 - 4.7e-07 29.3 0.1 9.8e-07 28.2 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Pkinase_Tyr PF07714.15 MSTRG.6231.1_2 - 4.2e-97 324.4 0.0 5.8e-97 323.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.6231.1_2 - 3.9e-47 160.7 0.0 5.9e-47 160.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain F_actin_bind PF08919.8 MSTRG.6231.1_2 - 1.2e-28 99.3 0.2 2.4e-28 98.3 0.2 1.6 1 0 0 1 1 1 1 F-actin binding SH2 PF00017.22 MSTRG.6231.1_2 - 2.7e-23 81.7 0.2 5.2e-23 80.8 0.2 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 MSTRG.6231.1_2 - 2.4e-12 46.1 0.0 5.4e-12 45.0 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.6231.1_2 - 2.1e-08 33.8 0.0 4.2e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.6231.1_2 - 3.2e-07 29.8 0.0 5.9e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 MSTRG.6231.1_2 - 0.00012 22.2 0.2 0.0003 20.9 0.2 1.7 1 0 0 1 1 1 1 Bacterial SH3 domain Pro_isomerase PF00160.19 MSTRG.16478.1_3 - 1.4e-36 126.0 0.1 2.2e-36 125.4 0.1 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.20 MSTRG.16478.1_3 - 1.1e-16 60.2 0.0 2e-16 59.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Closter_coat PF01785.15 MSTRG.22685.5_2 - 0.096 11.8 0.1 0.24 10.5 0.0 1.5 2 0 0 2 2 2 0 Closterovirus coat protein Forkhead PF00250.16 MSTRG.22685.5_3 - 2.3e-25 88.6 0.0 4.2e-25 87.8 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain WD40_3 PF15911.3 MSTRG.18903.1_1 - 1.4e-19 69.7 0.0 4.6e-19 68.1 0.0 1.9 2 0 0 2 2 2 1 WD domain, G-beta repeat SH2 PF00017.22 MSTRG.12259.2_2 - 1.2e-42 143.7 0.3 9.7e-21 73.5 0.0 2.4 2 0 0 2 2 2 2 SH2 domain PH PF00169.27 MSTRG.12259.2_2 - 5.5e-12 46.0 0.0 1.3e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.26 MSTRG.12259.2_2 - 4.2e-10 38.9 0.0 1.2e-09 37.5 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH2_2 PF14633.4 MSTRG.12259.2_2 - 2.4e-06 27.0 0.0 0.0067 15.7 0.0 2.2 2 0 0 2 2 2 2 SH2 domain SH3_9 PF14604.4 MSTRG.12259.2_2 - 2.4e-05 24.0 0.0 4.9e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.12259.2_2 - 0.00022 20.7 0.0 0.00058 19.4 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain PRIMA1 PF16101.3 MSTRG.12259.2_2 - 1.9 8.4 7.5 5.2 7.0 7.5 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 PLAC PF08686.9 MSTRG.10913.1_1 - 0.0074 16.9 1.3 0.016 15.8 1.3 1.5 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain Laminin_G_2 PF02210.22 MSTRG.10913.1_2 - 8.9e-19 68.2 0.1 1.3e-18 67.6 0.1 1.2 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.21 MSTRG.10913.1_2 - 5.9e-09 36.1 0.0 1.1e-08 35.2 0.0 1.5 1 1 0 1 1 1 1 Laminin G domain Laminin_G_3 PF13385.4 MSTRG.10913.1_2 - 3.4e-06 27.2 0.0 5e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DHR-2 PF06920.11 MSTRG.22922.4_1 - 8.8e-208 691.1 5.0 8.8e-208 691.1 5.0 2.0 2 0 0 2 2 2 1 Dock homology region 2 DOCK-C2 PF14429.4 MSTRG.22922.4_1 - 1.3e-56 191.3 0.1 1e-55 188.5 0.0 2.4 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.6 MSTRG.22922.4_1 - 4.2e-34 116.7 0.2 1.5e-33 114.9 0.2 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) PH PF00169.27 MSTRG.22922.4_1 - 2e-15 57.1 0.2 6e-15 55.5 0.2 1.9 1 0 0 1 1 1 1 PH domain PH_9 PF15410.4 MSTRG.22922.4_1 - 0.00014 22.0 0.0 0.00064 19.9 0.0 2.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.4 MSTRG.22922.4_1 - 0.046 13.9 0.1 0.13 12.4 0.1 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain HAUS6_N PF14661.4 MSTRG.22922.4_1 - 0.059 12.9 1.5 0.3 10.5 0.7 2.4 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus PH_11 PF15413.4 MSTRG.22922.4_1 - 0.17 12.1 1.2 4.3 7.7 1.2 2.9 1 1 0 1 1 1 0 Pleckstrin homology domain RRM_1 PF00076.20 MSTRG.25810.3_3 - 9.4e-09 34.8 0.2 0.0035 17.0 0.0 4.2 4 0 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_M24 PF00557.22 MSTRG.12877.2_1 - 2e-52 177.8 0.3 2.7e-52 177.4 0.3 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 HMG_box PF00505.17 MSTRG.14445.1_2 - 5.6e-15 55.4 1.3 1e-14 54.5 1.3 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 MSTRG.14445.1_2 - 9.4e-09 35.6 2.3 1.7e-08 34.8 2.3 1.4 1 0 0 1 1 1 1 HMG-box domain MATalpha_HMGbox PF04769.10 MSTRG.14445.1_2 - 0.031 13.4 0.1 0.048 12.8 0.1 1.2 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box Trp_oprn_chp PF09534.8 MSTRG.7432.2_1 - 0.12 12.0 0.1 13 5.4 0.0 2.2 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) EGF_2 PF07974.11 MSTRG.7432.2_1 - 0.4 10.9 5.1 1 9.7 5.1 1.7 1 0 0 1 1 1 0 EGF-like domain EGF PF00008.25 MSTRG.7432.2_1 - 2.8 8.2 10.9 0.1 12.8 3.8 2.2 2 0 0 2 2 2 0 EGF-like domain Astro_capsid_p PF12226.6 MSTRG.7432.2_1 - 6.6 5.7 6.3 9.4 5.1 6.3 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein NIF PF03031.16 MSTRG.20659.1_3 - 8.4e-30 103.5 0.0 1.3e-29 102.9 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase ubiquitin PF00240.21 MSTRG.20659.1_3 - 1.2e-07 31.2 0.1 2.3e-07 30.3 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.4 MSTRG.20659.1_3 - 0.028 14.7 0.1 0.069 13.5 0.1 1.6 1 0 0 1 1 1 0 Ubiquitin-like domain Acyl-CoA_dh_1 PF00441.22 MSTRG.15478.5_2 - 3.8e-28 98.5 0.2 6.5e-28 97.7 0.2 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.14 MSTRG.15478.5_2 - 1.7e-27 96.2 0.0 3.3e-27 95.3 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.17 MSTRG.15478.5_2 - 4e-24 84.5 0.0 6.6e-24 83.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.9 MSTRG.15478.5_2 - 4.1e-13 49.6 0.1 8.2e-13 48.7 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain KTI12 PF08433.8 MSTRG.15478.5_3 - 2.6e-18 66.3 0.0 3.6e-14 52.7 0.1 2.1 2 0 0 2 2 2 2 Chromatin associated protein KTI12 AAA_33 PF13671.4 MSTRG.15478.5_3 - 1.5e-10 41.2 0.0 1.7e-09 37.8 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 MSTRG.15478.5_3 - 8.7e-06 26.1 0.3 3.3e-05 24.2 0.1 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.4 MSTRG.15478.5_3 - 0.055 13.8 0.0 0.43 11.0 0.0 2.2 1 1 0 1 1 1 0 AAA domain ArgK PF03308.14 MSTRG.15478.5_3 - 0.1 11.4 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 ArgK protein 6PF2K PF01591.16 MSTRG.15478.5_3 - 0.13 11.5 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase PRY PF13765.4 MSTRG.8130.1_1 - 3.8e-16 58.3 0.0 9.5e-16 57.0 0.0 1.7 1 0 0 1 1 1 1 SPRY-associated domain zf-C3HC4_2 PF13923.4 MSTRG.8130.1_1 - 5.4e-10 38.8 11.0 5.4e-10 38.8 11.0 3.0 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.8130.1_1 - 2.4e-09 36.9 9.0 2.4e-09 36.9 9.0 2.4 2 0 0 2 2 1 1 RING-type zinc-finger zf-B_box PF00643.22 MSTRG.8130.1_1 - 6.4e-09 35.7 7.1 6.4e-09 35.7 7.1 4.3 4 1 0 4 4 4 1 B-box zinc finger zf-C3HC4_4 PF15227.4 MSTRG.8130.1_1 - 1.1e-08 35.0 9.6 1.1e-08 35.0 9.6 3.5 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 MSTRG.8130.1_1 - 2.6e-08 33.5 9.2 2.6e-08 33.5 9.2 3.3 4 1 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 MSTRG.8130.1_1 - 7.7e-07 28.7 8.7 7.7e-07 28.7 8.7 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.8130.1_1 - 1.8e-05 24.7 10.3 1.8e-05 24.7 10.3 3.5 3 0 0 3 3 2 1 Ring finger domain Prok-RING_4 PF14447.4 MSTRG.8130.1_1 - 0.00014 21.5 9.0 0.00014 21.5 9.0 3.4 3 1 1 4 4 4 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 MSTRG.8130.1_1 - 0.00095 18.9 11.8 0.00095 18.9 11.8 3.9 3 1 1 4 4 3 1 zinc-RING finger domain zf-RING_6 PF14835.4 MSTRG.8130.1_1 - 0.0034 17.1 3.0 0.0097 15.6 3.0 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-Nse PF11789.6 MSTRG.8130.1_1 - 0.0048 16.6 3.7 0.01 15.5 3.7 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.13 MSTRG.8130.1_1 - 0.033 14.2 0.0 0.089 12.9 0.0 1.7 1 0 0 1 1 1 0 U-box domain Mt_ATP-synt_D PF05873.10 MSTRG.8130.1_1 - 0.057 13.1 4.9 6.7 6.4 2.6 2.7 3 0 0 3 3 3 0 ATP synthase D chain, mitochondrial (ATP5H) DUF3509 PF12021.6 MSTRG.8130.1_1 - 0.059 13.0 1.5 0.13 11.9 0.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3509) XLF PF09302.9 MSTRG.8130.1_1 - 0.093 12.8 1.6 2 8.4 1.4 2.3 2 0 0 2 2 2 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component Apolipoprotein PF01442.16 MSTRG.8130.1_1 - 0.097 12.4 11.2 0.036 13.9 7.2 2.0 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain TagA PF12561.6 MSTRG.8130.1_1 - 0.12 12.4 0.5 0.27 11.2 0.5 1.5 1 0 0 1 1 1 0 ToxR activated gene A lipoprotein Fez1 PF06818.13 MSTRG.8130.1_1 - 0.13 12.6 11.5 0.096 13.0 9.8 1.6 2 0 0 2 2 2 0 Fez1 DUF4615 PF15393.4 MSTRG.8130.1_1 - 0.28 11.6 3.4 0.62 10.4 2.8 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4615) zf-H2C2_2 PF13465.4 MSTRG.8130.1_1 - 0.96 9.9 9.5 4 7.9 1.9 3.6 3 0 0 3 3 3 0 Zinc-finger double domain DUF4407 PF14362.4 MSTRG.8130.1_1 - 3.4 6.8 8.4 4.1 6.5 2.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) PIP5K PF01504.16 MSTRG.18702.3_2 - 5.8e-89 297.8 0.0 8.8e-89 297.2 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase SMC_N PF02463.17 MSTRG.9992.3_2 - 1.5e-54 184.6 0.0 3.4e-54 183.5 0.0 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.11 MSTRG.9992.3_2 - 2.4e-23 82.5 0.0 7.6e-23 80.9 0.0 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain HMMR_N PF15905.3 MSTRG.9992.3_2 - 0.00028 20.3 22.1 0.00028 20.3 22.1 6.2 2 2 4 6 6 6 1 Hyaluronan mediated motility receptor N-terminal AAA_21 PF13304.4 MSTRG.9992.3_2 - 0.00041 20.1 1.6 0.00054 19.7 0.0 2.0 2 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system Reo_sigmaC PF04582.10 MSTRG.9992.3_2 - 0.00051 19.4 41.5 0.033 13.4 4.4 5.2 2 2 3 5 5 5 4 Reovirus sigma C capsid protein TPR_MLP1_2 PF07926.10 MSTRG.9992.3_2 - 0.00056 19.8 17.0 0.00056 19.8 17.0 7.9 3 2 3 8 8 8 1 TPR/MLP1/MLP2-like protein Tropomyosin_1 PF12718.5 MSTRG.9992.3_2 - 0.0028 17.6 12.9 0.0028 17.6 12.9 7.9 3 2 4 7 7 7 1 Tropomyosin like Myosin_tail_1 PF01576.17 MSTRG.9992.3_2 - 0.79 7.3 121.1 0.12 10.0 68.7 2.7 2 1 0 2 2 2 0 Myosin tail DEAD PF00270.27 MSTRG.11509.1_3 - 5e-49 166.3 0.0 1.7e-48 164.6 0.0 1.8 1 1 1 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.11509.1_3 - 4e-31 107.5 0.0 9.2e-31 106.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.11509.1_3 - 0.0015 18.5 0.0 0.0044 16.9 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.3 MSTRG.11509.1_3 - 0.019 14.1 0.1 0.03 13.4 0.1 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase AAA_19 PF13245.4 MSTRG.11509.1_3 - 0.06 13.5 0.0 5.4 7.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain Helicase_C_2 PF13307.4 MSTRG.11509.1_3 - 0.12 12.4 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Helicase C-terminal domain bZIP_2 PF07716.13 MSTRG.21756.2_3 - 2.2e-14 53.1 12.5 5.1e-14 52.0 12.5 1.7 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.19 MSTRG.21756.2_3 - 0.00021 21.2 8.8 0.0005 20.0 8.8 1.6 1 0 0 1 1 1 1 bZIP transcription factor Vert_IL3-reg_TF PF06529.9 MSTRG.21756.2_3 - 0.33 9.9 17.8 0.48 9.4 4.5 2.6 2 1 0 2 2 2 0 Vertebrate interleukin-3 regulated transcription factor RILP PF11461.6 MSTRG.20895.1_3 - 3.8e-22 78.1 1.5 9.2e-22 76.9 1.5 1.7 1 0 0 1 1 1 1 Rab interacting lysosomal protein Jnk-SapK_ap_N PF09744.7 MSTRG.20895.1_3 - 4e-10 40.0 4.8 4e-10 40.0 4.8 2.7 3 0 0 3 3 3 1 JNK_SAPK-associated protein-1 Fez1 PF06818.13 MSTRG.20895.1_3 - 2.1 8.6 16.9 0.21 11.9 11.9 1.7 2 0 0 2 2 2 0 Fez1 HAP1_N PF04849.11 MSTRG.20895.1_3 - 3.8 6.5 20.8 0.42 9.6 14.4 2.1 2 0 0 2 2 2 0 HAP1 N-terminal conserved region Spc7 PF08317.9 MSTRG.20895.1_3 - 5.2 5.7 12.6 8.4 5.0 12.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Pkinase PF00069.23 MSTRG.25643.2_1 - 8.1e-42 143.3 0.0 8.1e-33 113.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.25643.2_1 - 9.7e-31 106.8 0.0 3.8e-23 82.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.12 MSTRG.25643.2_1 - 0.00065 19.0 0.0 0.0012 18.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 MSTRG.25643.2_1 - 0.0038 17.1 0.1 0.0093 15.8 0.1 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family RNA_polI_A34 PF08208.9 MSTRG.2978.1_3 - 6.9 6.6 19.7 14 5.6 19.6 1.6 1 1 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Acyl-CoA_dh_1 PF00441.22 MSTRG.5641.2_3 - 9.4e-29 100.4 0.7 1.4e-28 99.8 0.7 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.17 MSTRG.5641.2_3 - 8.5e-10 38.6 0.0 1.5e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.9 MSTRG.5641.2_3 - 1.5e-09 38.1 0.1 2.5e-09 37.4 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain DOCK_N PF16172.3 MSTRG.2961.1_1 - 5.8e-103 344.6 0.0 1.1e-102 343.6 0.0 1.5 1 0 0 1 1 1 1 DOCK N-terminus DHR-2 PF06920.11 MSTRG.2961.1_1 - 1.5e-95 320.8 5.0 8.3e-95 318.3 5.0 2.0 1 1 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.4 MSTRG.2961.1_1 - 3.2e-55 186.8 0.0 1.8e-54 184.4 0.0 2.2 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins SH3_9 PF14604.4 MSTRG.2961.1_1 - 6e-08 32.3 0.0 1.3e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.2961.1_1 - 1.4e-07 30.9 0.0 2.8e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.2961.1_1 - 4.9e-07 29.2 0.1 1e-06 28.2 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain GEMIN8 PF15348.4 MSTRG.20152.1_1 - 2.2e-75 253.9 24.1 1.1e-62 212.4 4.6 2.0 1 1 1 2 2 2 2 Gemini of Cajal bodies-associated protein 8 CDK2AP PF09806.7 MSTRG.11422.1_1 - 4.8e-20 72.5 0.0 6.7e-20 72.0 0.0 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase 2-associated protein DUF2207 PF09972.7 MSTRG.803.1_1 - 0.0013 17.5 0.2 0.0013 17.4 0.2 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) FixQ PF05545.9 MSTRG.803.1_1 - 0.0019 18.0 0.4 0.0024 17.6 0.4 1.2 1 0 0 1 1 1 1 Cbb3-type cytochrome oxidase component FixQ DUF4381 PF14316.4 MSTRG.803.1_1 - 0.0019 18.3 0.1 0.0021 18.2 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) Syndecan PF01034.18 MSTRG.803.1_1 - 0.022 14.5 0.2 0.027 14.2 0.2 1.2 1 0 0 1 1 1 0 Syndecan domain DUF485 PF04341.10 MSTRG.803.1_1 - 0.027 14.3 0.0 0.038 13.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF485 Herpes_gE PF02480.14 MSTRG.803.1_1 - 0.028 13.0 0.0 0.03 12.9 0.0 1.0 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E NfeD PF01957.16 MSTRG.803.1_1 - 0.071 13.4 0.0 0.082 13.2 0.0 1.1 1 0 0 1 1 1 0 NfeD-like C-terminal, partner-binding YajC PF02699.13 MSTRG.803.1_1 - 0.075 12.8 0.1 0.11 12.3 0.1 1.2 1 0 0 1 1 1 0 Preprotein translocase subunit HemY_N PF07219.11 MSTRG.803.1_1 - 0.096 12.7 0.3 0.13 12.3 0.3 1.2 1 0 0 1 1 1 0 HemY protein N-terminus EphA2_TM PF14575.4 MSTRG.803.1_1 - 0.11 13.1 0.0 0.15 12.8 0.0 1.2 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF2970 PF11174.6 MSTRG.803.1_1 - 5 6.9 8.8 8.8 6.1 8.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2970) Ank_2 PF12796.5 MSTRG.21954.2_2 - 3e-17 62.9 0.1 6.4e-17 61.8 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.21954.2_2 - 7e-15 55.1 1.0 6.3e-10 39.3 0.3 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.21954.2_2 - 6.6e-14 51.5 1.0 1.2e-05 25.4 0.2 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.4 MSTRG.21954.2_2 - 4.1e-13 48.1 0.6 1.9e-05 24.6 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeat SH3_1 PF00018.26 MSTRG.21954.2_2 - 6.3e-12 44.8 1.1 1.4e-11 43.6 0.4 1.9 2 0 0 2 2 2 1 SH3 domain Ank_5 PF13857.4 MSTRG.21954.2_2 - 6.7e-11 42.1 0.4 2.2e-07 30.9 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SH3_9 PF14604.4 MSTRG.21954.2_2 - 1.2e-09 37.7 1.1 1.9e-09 37.1 0.2 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.21954.2_2 - 2.2e-07 30.3 0.0 1.1e-06 28.0 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain p450 PF00067.20 MSTRG.5401.1_2 - 4.9e-106 355.1 0.0 6.3e-106 354.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PNRC PF15365.4 MSTRG.8870.1_3 - 0.12 12.8 0.2 0.19 12.2 0.2 1.3 1 0 0 1 1 1 0 Proline-rich nuclear receptor coactivator YTH PF04146.13 MSTRG.16704.5_3 - 3.3e-41 139.7 0.0 4.5e-41 139.2 0.0 1.2 1 0 0 1 1 1 1 YT521-B-like domain FERM_C PF09380.8 MSTRG.9098.1_3 - 1.8e-24 85.8 0.0 4.7e-24 84.5 0.0 1.7 1 0 0 1 1 1 1 FERM C-terminal PH-like domain SAB PF04382.11 MSTRG.9098.1_3 - 6.1e-23 80.5 2.3 6.1e-23 80.5 2.3 4.0 2 1 1 3 3 3 1 SAB domain FA PF08736.9 MSTRG.9098.1_3 - 2.6e-18 65.7 4.7 1.2e-17 63.6 4.7 2.3 1 0 0 1 1 1 1 FERM adjacent (FA) FERM_N PF09379.8 MSTRG.9098.1_3 - 1.2e-16 60.3 0.0 3.2e-16 58.9 0.0 1.8 1 0 0 1 1 1 1 FERM N-terminal domain FERM_M PF00373.16 MSTRG.9098.1_3 - 7.9e-15 55.2 0.0 7.9e-15 55.2 0.0 2.9 2 1 0 2 2 2 1 FERM central domain WD40 PF00400.30 MSTRG.4718.1_2 - 0.011 16.4 0.4 7.9 7.4 0.1 2.5 2 0 0 2 2 2 0 WD domain, G-beta repeat Spot_14 PF07084.10 MSTRG.22867.1_1 - 2.7e-46 157.4 0.5 3.5e-46 157.0 0.5 1.1 1 0 0 1 1 1 1 Thyroid hormone-inducible hepatic protein Spot 14 IMUP PF15761.3 MSTRG.22867.1_1 - 0.072 13.6 1.3 0.12 12.9 1.3 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein V-set PF07686.15 MSTRG.923.1_1 - 5e-18 65.1 0.0 6.9e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 MSTRG.923.1_1 - 1.2e-05 25.2 0.0 3.7e-05 23.7 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.923.1_1 - 0.00019 21.8 0.0 0.00058 20.3 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 MSTRG.923.1_1 - 0.0058 16.5 0.0 0.014 15.4 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.923.1_1 - 0.094 12.9 0.7 1 9.6 0.2 2.5 2 1 0 2 2 2 0 Immunoglobulin domain SH2 PF00017.22 MSTRG.8977.1_2 - 2e-13 50.1 0.0 3.9e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 SH2 domain Trypsin PF00089.24 MSTRG.10434.2_2 - 8.5e-67 225.1 0.0 8.5e-67 225.1 0.0 1.9 2 0 0 2 2 2 1 Trypsin Gla PF00594.18 MSTRG.10434.2_2 - 1.7e-16 59.9 8.2 3.9e-16 58.8 8.2 1.6 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FXa_inhibition PF14670.4 MSTRG.10434.2_2 - 1.5e-09 37.9 27.9 2.8e-09 37.0 11.7 2.7 2 0 0 2 2 2 2 Coagulation Factor Xa inhibitory site Trypsin_2 PF13365.4 MSTRG.10434.2_2 - 1.9e-07 31.9 0.0 3.4e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 MSTRG.10434.2_2 - 6.5e-07 29.6 0.0 2.9e-06 27.5 0.0 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) EGF PF00008.25 MSTRG.10434.2_2 - 5.2e-05 23.3 6.5 5.2e-05 23.3 6.5 3.0 3 0 0 3 3 3 2 EGF-like domain hEGF PF12661.5 MSTRG.10434.2_2 - 0.00046 20.6 4.8 0.00046 20.6 4.8 4.3 3 1 0 3 3 3 1 Human growth factor-like EGF EGF_3 PF12947.5 MSTRG.10434.2_2 - 0.029 14.4 23.5 0.046 13.8 7.6 3.0 2 0 0 2 2 2 0 EGF domain Toxin_29 PF08116.9 MSTRG.10434.2_2 - 0.034 14.0 2.4 0.12 12.3 2.4 2.0 1 0 0 1 1 1 0 PhTx neurotoxin family cEGF PF12662.5 MSTRG.10434.2_2 - 2.1 8.2 24.3 0.12 12.2 1.2 3.1 3 1 0 3 3 3 0 Complement Clr-like EGF-like EGF_2 PF07974.11 MSTRG.10434.2_2 - 7.8 6.8 30.9 0.038 14.2 10.1 3.2 3 0 0 3 3 3 0 EGF-like domain Cystatin PF00031.19 MSTRG.7767.1_1 - 9.9e-17 60.9 0.1 2.5e-16 59.6 0.0 1.7 2 0 0 2 2 2 1 Cystatin domain SQAPI PF16845.3 MSTRG.7767.1_1 - 2.9e-05 24.2 0.3 6.3e-05 23.1 0.3 1.5 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor Cas_csx3 PF09620.8 MSTRG.18353.1_1 - 0.078 12.7 0.2 0.15 11.8 0.2 1.4 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_csx3) TMEM234 PF10639.7 MSTRG.18353.1_2 - 3.4e-44 149.5 2.6 5.5e-44 148.8 2.6 1.3 1 0 0 1 1 1 1 Putative transmembrane family 234 EamA PF00892.18 MSTRG.18353.1_2 - 0.0017 18.4 2.7 0.15 12.1 1.5 2.5 1 1 0 2 2 2 2 EamA-like transporter family COX6C PF02937.13 MSTRG.13653.4_1 - 8.7e-33 112.1 0.2 1.2e-32 111.7 0.2 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIc SF3a60_bindingd PF12108.6 MSTRG.13653.4_1 - 0.16 11.7 0.7 0.28 10.9 0.7 1.3 1 0 0 1 1 1 0 Splicing factor SF3a60 binding domain KRTDAP PF15200.4 MSTRG.4432.1_1 - 0.05 13.3 0.6 0.32 10.7 0.0 2.0 2 0 0 2 2 2 0 Keratinocyte differentiation-associated MFS_1 PF07690.14 MSTRG.4432.1_3 - 2.8e-21 75.7 13.0 3.8e-21 75.3 13.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.22 MSTRG.4432.1_3 - 1.9e-05 23.6 1.0 2.2e-05 23.4 1.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Collagen PF01391.16 MSTRG.7038.1_3 - 6.2e-35 118.6 172.2 3e-09 36.4 28.5 8.2 3 3 3 6 6 6 6 Collagen triple helix repeat (20 copies) Laminin_G_3 PF13385.4 MSTRG.7038.1_3 - 0.0007 19.6 0.0 0.002 18.2 0.0 1.7 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily CIA30 PF08547.10 MSTRG.8829.2_3 - 7.6e-52 175.4 0.0 1.1e-51 174.9 0.0 1.3 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) CBM_11 PF03425.11 MSTRG.8829.2_3 - 0.00023 21.0 0.0 0.00036 20.3 0.0 1.3 1 0 0 1 1 1 1 Carbohydrate binding domain (family 11) APOBEC_N PF08210.9 MSTRG.20250.4_1 - 8.7e-45 152.7 0.6 1.3e-44 152.1 0.6 1.3 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC_C PF05240.12 MSTRG.20250.4_1 - 1.5e-25 88.8 0.1 2.3e-25 88.2 0.1 1.3 1 0 0 1 1 1 1 APOBEC-like C-terminal domain MafB19-deam PF14437.4 MSTRG.20250.4_1 - 6.8e-05 22.5 0.6 0.00018 21.2 0.0 1.9 2 0 0 2 2 2 1 MafB19-like deaminase dCMP_cyt_deam_1 PF00383.21 MSTRG.20250.4_1 - 0.00021 21.0 0.4 0.00043 20.0 0.3 1.6 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region TPR_11 PF13414.4 MSTRG.9931.3_1 - 0.00023 20.6 0.6 0.046 13.3 0.1 2.9 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.15 MSTRG.9931.3_1 - 0.0031 17.4 4.7 0.59 10.3 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.9931.3_1 - 0.019 15.4 0.1 0.059 13.8 0.1 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.9931.3_1 - 0.26 11.0 3.5 33 4.4 0.3 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Sprouty PF05210.11 MSTRG.20842.2_1 - 1.7e-30 105.4 29.6 1.7e-30 105.4 29.6 2.3 2 0 0 2 2 2 1 Sprouty protein (Spry) MHC_I PF00129.16 MSTRG.19712.3_2 - 3.6e-35 121.0 3.3 4.9e-35 120.6 3.3 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 MSTRG.19712.3_2 - 1.3e-09 38.2 0.0 2.9e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.3 MSTRG.19712.3_2 - 0.00012 21.5 0.3 0.0002 20.7 0.3 1.3 1 0 0 1 1 1 1 MHC-I family domain TMEM154 PF15102.4 MSTRG.19712.3_2 - 0.00045 20.0 0.0 0.00088 19.1 0.0 1.4 1 0 0 1 1 1 1 TMEM154 protein family SecG PF03840.12 MSTRG.19712.3_2 - 0.049 13.6 0.0 0.094 12.7 0.0 1.4 1 0 0 1 1 1 0 Preprotein translocase SecG subunit CHCH PF06747.11 MSTRG.1518.1_1 - 1.5e-07 31.2 3.0 2.6e-07 30.5 3.0 1.4 1 0 0 1 1 1 1 CHCH domain MTCP1 PF08991.8 MSTRG.1518.1_1 - 0.065 13.3 0.5 0.16 12.1 0.5 1.6 1 0 0 1 1 1 0 Mature-T-Cell Proliferation I type 3Beta_HSD PF01073.17 MSTRG.7383.2_3 - 5.6e-66 222.3 0.0 7.9e-66 221.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 MSTRG.7383.2_3 - 4.5e-35 121.1 0.0 6e-35 120.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 MSTRG.7383.2_3 - 1.1e-15 57.8 0.0 1.1e-13 51.2 0.0 2.4 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.4 MSTRG.7383.2_3 - 3e-15 56.5 0.0 4.3e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.15 MSTRG.7383.2_3 - 4.5e-14 52.1 0.0 6.2e-14 51.6 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.10 MSTRG.7383.2_3 - 1.8e-09 37.0 0.0 6.7e-05 22.0 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein NmrA PF05368.11 MSTRG.7383.2_3 - 1.6e-07 31.0 0.0 2.4e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.13 MSTRG.7383.2_3 - 0.00016 20.7 0.0 0.00051 19.1 0.0 1.7 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 2-oxoacid_dh PF00198.21 MSTRG.24370.1_2 - 2.8e-72 242.8 0.0 3.3e-72 242.6 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Carb_anhydrase PF00194.19 MSTRG.15506.2_2 - 4.5e-143 475.1 0.0 2.2e-70 237.0 0.0 2.3 2 0 0 2 2 2 2 Eukaryotic-type carbonic anhydrase S4_2 PF13275.4 MSTRG.15506.2_2 - 0.013 15.2 0.3 1.2 8.9 0.0 2.4 2 0 0 2 2 2 0 S4 domain HCO3_cotransp PF00955.19 MSTRG.27987.2_2 - 1.9e-44 152.3 1.5 2.6e-44 151.8 1.5 1.2 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 MSTRG.27987.2_2 - 3e-05 23.8 0.0 4.3e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Band 3 cytoplasmic domain PTS_EIIA_2 PF00359.20 MSTRG.27987.2_2 - 0.00033 20.4 0.0 0.00058 19.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 zf-RanBP PF00641.16 MSTRG.27987.2_2 - 0.053 12.7 1.1 0.11 11.6 1.1 1.5 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others Bromodomain PF00439.23 MSTRG.28503.1_3 - 6e-15 55.0 1.3 7.6e-15 54.6 0.9 1.4 1 1 0 1 1 1 1 Bromodomain SRF-TF PF00319.16 MSTRG.16679.2_3 - 1.3e-22 78.9 0.5 1.3e-22 78.9 0.5 2.1 2 0 0 2 2 2 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.6 MSTRG.16679.2_3 - 0.064 13.1 0.0 0.064 13.1 0.0 2.5 3 0 0 3 3 3 0 Holliday junction regulator protein family C-terminal repeat COMM_domain PF07258.12 MSTRG.18771.1_2 - 4e-14 52.4 6.7 4.3e-14 52.3 3.6 2.2 2 0 0 2 2 2 1 COMM domain EFP PF01132.18 MSTRG.18771.1_3 - 0.14 12.1 0.0 2 8.4 0.0 2.2 2 0 0 2 2 2 0 Elongation factor P (EF-P) OB domain EF-hand_7 PF13499.4 MSTRG.26544.2_3 - 5.2e-25 87.6 8.3 5.9e-24 84.2 2.2 3.7 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.30 MSTRG.26544.2_3 - 1.6e-05 24.0 0.2 0.086 12.3 0.1 4.5 6 0 0 6 6 6 1 EF hand EF-hand_6 PF13405.4 MSTRG.26544.2_3 - 3.5e-05 23.3 0.4 0.055 13.3 0.0 4.2 4 0 0 4 4 4 1 EF-hand domain EF-hand_5 PF13202.4 MSTRG.26544.2_3 - 0.00028 20.1 0.0 0.0034 16.7 0.0 2.8 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.4 MSTRG.26544.2_3 - 0.0081 15.8 1.0 0.88 9.3 0.0 4.4 7 0 0 7 7 7 1 EF-hand domain pair SPARC_Ca_bdg PF10591.7 MSTRG.26544.2_3 - 0.11 12.6 4.8 5.2 7.3 0.2 3.0 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Robl_LC7 PF03259.15 MSTRG.18428.1_2 - 1.8e-17 62.8 0.1 2.6e-17 62.2 0.1 1.2 1 0 0 1 1 1 1 Roadblock/LC7 domain LAMTOR5 PF16672.3 MSTRG.18428.1_2 - 0.027 14.2 0.0 0.048 13.4 0.0 1.3 1 0 0 1 1 1 0 Ragulator complex protein LAMTOR5 Sas10_Utp3 PF04000.13 MSTRG.18315.7_1 - 4.9e-14 52.6 0.0 7e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 Sas10/Utp3/C1D family DUF932 PF06067.9 MSTRG.18315.7_1 - 0.016 14.8 0.2 0.019 14.6 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF932) PIEZO PF15917.3 MSTRG.18315.7_1 - 0.1 11.9 0.4 0.12 11.7 0.4 1.0 1 0 0 1 1 1 0 Piezo Pkinase_Tyr PF07714.15 MSTRG.24146.1_2 - 1.2e-61 208.1 0.0 1.7e-61 207.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.24146.1_2 - 8.5e-31 107.1 0.0 1.4e-30 106.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Gla PF00594.18 MSTRG.24146.1_2 - 0.76 9.9 4.7 2.4 8.3 4.7 1.8 1 0 0 1 1 1 0 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain 7tm_1 PF00001.19 MSTRG.13093.5_3 - 1.2e-43 149.2 18.5 1.2e-43 149.2 18.5 2.1 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 MSTRG.13093.5_3 - 0.00061 19.1 23.3 0.00061 19.1 23.3 2.1 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 MSTRG.13093.5_3 - 1.6 7.8 33.5 0.0077 15.5 22.0 2.6 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srv TPR_10 PF13374.4 MSTRG.14776.3_1 - 4.8e-55 181.9 11.8 3.6e-15 55.2 0.0 6.7 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.14776.3_1 - 2.7e-51 171.6 7.7 2.1e-19 69.4 1.2 5.0 3 1 2 5 5 5 5 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.14776.3_1 - 7.8e-22 75.5 15.1 2e-05 24.1 0.0 7.4 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.14776.3_1 - 1.1e-20 72.4 29.8 5.8e-07 28.9 0.5 6.5 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.14776.3_1 - 1.1e-13 50.0 26.7 0.0029 17.5 0.4 6.5 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.14776.3_1 - 2.9e-10 39.4 23.9 0.0064 16.5 0.1 6.7 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.14776.3_1 - 5.5e-10 39.6 3.6 0.019 15.5 1.3 5.2 2 1 3 5 5 5 4 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.14776.3_1 - 4.8e-07 30.1 7.1 0.028 14.8 0.6 3.7 2 1 3 5 5 4 3 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.14776.3_1 - 1.4e-06 28.2 7.4 1.1 9.7 0.1 5.8 5 0 0 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.14776.3_1 - 0.00015 21.8 8.2 0.013 15.6 0.4 3.4 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.4 MSTRG.14776.3_1 - 0.00032 21.1 6.1 27 5.8 0.2 5.9 3 1 3 6 6 6 0 Tetratricopeptide repeat TPR_4 PF07721.12 MSTRG.14776.3_1 - 0.0021 18.4 0.1 7.7 7.3 0.2 4.5 5 0 0 5 5 4 1 Tetratricopeptide repeat PPR PF01535.18 MSTRG.14776.3_1 - 0.0055 16.7 0.3 0.76 10.0 0.0 3.5 3 0 0 3 3 2 1 PPR repeat DUF627 PF04781.10 MSTRG.14776.3_1 - 0.017 15.0 2.4 1.6 8.6 0.0 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF627) JIP_LZII PF16471.3 MSTRG.14776.3_1 - 0.41 10.7 10.8 0.011 15.7 4.3 1.8 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II COG2 PF06148.9 MSTRG.14776.3_1 - 0.42 10.6 4.6 0.96 9.4 4.4 1.7 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Ank_2 PF12796.5 MSTRG.21725.2_2 - 3.7e-39 133.1 0.4 6.4e-14 52.2 0.1 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.21725.2_2 - 1.5e-32 111.4 1.4 5.7e-10 39.4 0.1 5.5 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.4 MSTRG.21725.2_2 - 3.7e-32 109.7 0.4 4.8e-07 29.8 0.0 5.9 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Caskin1-CID PF16600.3 MSTRG.21725.2_2 - 4.3e-30 103.9 6.8 4.3e-30 103.9 6.8 5.6 6 0 0 6 6 4 1 Caskin1 CASK-interaction domain Caskin-Pro-rich PF16907.3 MSTRG.21725.2_2 - 2.6e-28 98.3 8.2 2.6e-28 98.3 8.2 5.5 4 0 0 4 4 2 1 Proline rich region of Caskin proteins Ank PF00023.28 MSTRG.21725.2_2 - 5e-28 96.2 7.1 3.7e-06 27.0 0.1 7.0 7 0 0 7 7 6 6 Ankyrin repeat Caskin-tail PF16632.3 MSTRG.21725.2_2 - 3.7e-24 84.8 7.4 9.2e-24 83.5 7.4 1.7 1 0 0 1 1 1 1 C-terminal region of Caskin Ank_3 PF13606.4 MSTRG.21725.2_2 - 9.5e-24 80.8 2.0 3.2e-05 23.8 0.1 6.9 6 0 0 6 6 6 4 Ankyrin repeat SAM_1 PF00536.28 MSTRG.21725.2_2 - 6.4e-22 77.6 0.5 1.7e-16 60.3 0.1 2.5 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 MSTRG.21725.2_2 - 4.7e-17 61.7 0.3 7.9e-12 45.0 0.1 2.6 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SH3_2 PF07653.15 MSTRG.21725.2_2 - 1.5e-07 30.8 0.0 2.9e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.21725.2_2 - 0.00022 20.6 0.0 0.00043 19.7 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.21725.2_2 - 0.00051 19.7 0.0 0.0009 18.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Pkinase PF00069.23 MSTRG.8997.3_1 - 5.1e-73 245.5 0.0 6.5e-73 245.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.8997.3_1 - 4.9e-47 160.3 0.0 6.8e-47 159.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.8997.3_1 - 2.1e-07 30.5 0.1 0.00041 19.6 0.0 2.2 1 1 1 2 2 2 2 Kinase-like Kdo PF06293.12 MSTRG.8997.3_1 - 0.0078 15.5 0.0 0.015 14.5 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 MSTRG.8997.3_1 - 0.0085 15.9 0.0 0.25 11.1 0.2 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family MRI PF15325.4 MSTRG.8997.3_1 - 0.078 14.0 0.5 0.17 12.9 0.5 1.5 1 0 0 1 1 1 0 Modulator of retrovirus infection PBD PF00786.26 MSTRG.8997.3_2 - 5e-25 87.5 0.1 8.8e-25 86.8 0.1 1.4 1 0 0 1 1 1 1 P21-Rho-binding domain CTNNB1_binding PF08347.9 MSTRG.19604.2_1 - 8.1e-46 156.6 0.0 8.1e-46 156.6 0.0 2.2 2 0 0 2 2 2 1 N-terminal CTNNB1 binding HMG_box PF00505.17 MSTRG.19604.2_1 - 9.2e-18 64.3 0.1 1.7e-17 63.5 0.1 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 MSTRG.19604.2_1 - 3.6e-09 36.9 0.1 7.9e-09 35.9 0.1 1.5 1 0 0 1 1 1 1 HMG-box domain Forkhead PF00250.16 MSTRG.23153.1_1 - 2.6e-37 126.9 0.0 4.6e-37 126.1 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain zf-RING_6 PF14835.4 MSTRG.13876.1_2 - 0.11 12.3 0.2 0.11 12.3 0.2 1.8 2 0 0 2 2 2 0 zf-RING of BARD1-type protein Pkinase PF00069.23 MSTRG.13876.1_3 - 9.4e-64 215.2 0.0 1.3e-63 214.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.13876.1_3 - 4.7e-25 88.2 0.0 7.3e-25 87.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 MSTRG.13876.1_3 - 1.6e-05 24.2 0.0 2.8e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 MSTRG.13876.1_3 - 0.0044 16.2 0.0 0.0064 15.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like CHCH PF06747.11 MSTRG.888.1_1 - 2.5e-06 27.3 3.8 5.3e-06 26.3 3.8 1.6 1 0 0 1 1 1 1 CHCH domain GCK PF07802.9 MSTRG.888.1_1 - 0.0056 16.9 2.2 0.087 13.1 0.2 2.2 1 1 1 2 2 2 1 GCK domain COX17 PF05051.11 MSTRG.888.1_1 - 0.0086 16.3 1.5 0.022 15.0 1.5 1.7 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) Cmc1 PF08583.8 MSTRG.888.1_1 - 0.039 13.8 2.8 3.4 7.6 0.2 2.5 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.3 MSTRG.888.1_1 - 0.083 12.8 3.9 1.4 8.9 0.5 2.6 1 1 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Tctex-1 PF03645.11 MSTRG.20077.1_3 - 2.7e-25 88.5 2.0 4.7e-25 87.7 2.0 1.4 1 0 0 1 1 1 1 Tctex-1 family Snf7 PF03357.19 MSTRG.9329.1_1 - 5.5e-56 188.7 19.4 7.6e-56 188.3 19.4 1.2 1 0 0 1 1 1 1 Snf7 SYF2 PF08231.10 MSTRG.9329.1_1 - 0.003 17.8 8.6 0.0057 16.9 8.6 1.3 1 0 0 1 1 1 1 SYF2 splicing factor FKBP_C PF00254.26 MSTRG.2450.2_1 - 2.5e-77 255.2 0.0 1.4e-24 86.0 0.0 3.9 4 0 0 4 4 4 3 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_C PF00254.26 MSTRG.2450.2_3 - 1.2e-11 44.6 0.0 2e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_7 PF13499.4 MSTRG.2450.2_3 - 0.00064 20.0 0.2 0.0042 17.4 0.2 2.0 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 MSTRG.2450.2_3 - 0.00076 18.7 1.7 0.56 9.8 0.3 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 MSTRG.2450.2_3 - 0.0037 17.0 0.6 1.4 9.0 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.4 MSTRG.2450.2_3 - 0.0093 15.6 0.9 3.6 7.3 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.2450.2_3 - 0.03 13.7 1.6 1.8 8.1 0.4 2.3 2 0 0 2 2 2 0 EF hand Cast PF10174.7 MSTRG.18433.1_2 - 3.3e-235 782.7 84.0 3.8e-235 782.5 84.0 1.0 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone IncA PF04156.12 MSTRG.18433.1_2 - 0.0032 17.2 18.1 0.0032 17.2 18.1 5.4 1 1 3 4 4 4 3 IncA protein Reo_sigmaC PF04582.10 MSTRG.18433.1_2 - 0.36 10.1 20.9 0.013 14.7 9.0 3.1 2 1 3 5 5 5 0 Reovirus sigma C capsid protein RraB PF06877.9 MSTRG.18433.1_2 - 3.7 8.2 6.1 0.67 10.6 0.1 3.0 3 0 0 3 3 3 0 Regulator of ribonuclease activity B DUF4407 PF14362.4 MSTRG.18433.1_2 - 8.2 5.5 53.9 0.47 9.6 5.9 4.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) Fez1 PF06818.13 MSTRG.18433.1_2 - 8.6 6.6 84.0 0.81 10.0 23.1 4.9 1 1 4 5 5 5 0 Fez1 AMH_N PF04709.10 MSTRG.23644.1_2 - 0.015 14.1 0.0 0.02 13.7 0.0 1.1 1 0 0 1 1 1 0 Anti-Mullerian hormone, N terminal region RRM_1 PF00076.20 MSTRG.8679.1_2 - 6.2e-09 35.4 0.0 1.3e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) N-SET PF11764.6 MSTRG.8679.1_2 - 3.2e-06 27.2 0.4 3.2e-06 27.2 0.4 2.8 3 0 0 3 3 3 1 COMPASS (Complex proteins associated with Set1p) component N SET PF00856.26 MSTRG.8679.1_3 - 3.4e-18 66.5 1.3 8.4e-18 65.2 1.3 1.7 1 1 0 1 1 1 1 SET domain N-SET PF11764.6 MSTRG.8679.1_3 - 2e-15 57.2 0.1 4.9e-15 55.9 0.1 1.6 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component N GDPD PF03009.15 MSTRG.8005.1_1 - 9.2e-20 71.3 0.2 5e-19 68.9 0.2 1.9 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.4 MSTRG.8005.1_1 - 0.0012 19.2 0.9 0.0026 18.1 0.9 1.6 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family DUF2721 PF11026.6 MSTRG.8005.1_1 - 0.65 9.7 7.1 1.2 8.9 5.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) CRCB PF02537.13 MSTRG.8005.1_1 - 2.5 8.3 5.3 1 9.6 2.0 2.0 2 1 0 2 2 2 0 CrcB-like protein, Camphor Resistance (CrcB) ORMDL PF04061.12 MSTRG.21907.1_2 - 5e-52 175.2 3.5 5e-52 175.2 3.5 1.6 2 0 0 2 2 2 1 ORMDL family PAP2 PF01569.19 MSTRG.21907.1_3 - 3 7.5 7.1 7.8 6.2 4.9 2.2 2 0 0 2 2 2 0 PAP2 superfamily HECT_2 PF09814.7 MSTRG.24576.1_1 - 3.5e-66 223.5 1.1 4e-66 223.3 1.1 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding IDH PF03971.12 MSTRG.24576.1_3 - 0.14 10.5 0.1 0.19 10.0 0.1 1.0 1 0 0 1 1 1 0 Monomeric isocitrate dehydrogenase Nic96 PF04097.12 MSTRG.18404.2_1 - 1.1e-179 598.7 0.0 1.2e-179 598.6 0.0 1.0 1 0 0 1 1 1 1 Nup93/Nic96 Nup84_Nup100 PF04121.11 MSTRG.18404.2_1 - 0.02 13.0 0.2 0.034 12.2 0.2 1.3 1 0 0 1 1 1 0 Nuclear pore protein 84 / 107 MIT PF04212.16 MSTRG.18404.2_1 - 0.15 12.1 0.2 0.49 10.4 0.2 1.9 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain UPRTase PF14681.4 MSTRG.6583.1_1 - 1.1e-73 247.0 0.1 1.6e-73 246.4 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRK PF00485.16 MSTRG.6583.1_1 - 1.4e-61 207.5 0.0 2e-61 207.0 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family CPT PF07931.10 MSTRG.6583.1_1 - 1.8e-06 27.8 0.0 3.3e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.4 MSTRG.6583.1_1 - 1.9e-05 25.1 0.0 3.5e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.4 MSTRG.6583.1_1 - 0.00023 21.2 0.0 0.0004 20.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.4 MSTRG.6583.1_1 - 0.012 16.0 0.1 3.3 8.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.16 MSTRG.6583.1_1 - 0.02 14.5 0.0 0.45 10.1 0.0 2.2 2 0 0 2 2 2 0 Cytidylate kinase CoaE PF01121.18 MSTRG.6583.1_1 - 0.031 13.8 0.5 0.23 11.0 0.1 2.2 2 0 0 2 2 2 0 Dephospho-CoA kinase 7tm_2 PF00002.22 MSTRG.9447.2_2 - 5.3e-17 61.8 1.4 9.5e-17 61.0 1.4 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Sec7 PF01369.18 MSTRG.5197.2_1 - 1.5e-69 233.3 0.6 3.9e-69 231.9 0.6 1.8 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.5 MSTRG.5197.2_1 - 2e-50 170.7 6.4 3.7e-50 169.9 3.8 3.0 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.3 MSTRG.5197.2_1 - 2.8e-42 144.3 0.4 2.8e-42 144.3 0.4 3.1 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 DUF1981 PF09324.8 MSTRG.5197.2_1 - 5.3e-36 122.2 0.2 5.3e-36 122.2 0.2 4.9 6 0 0 6 6 6 1 Domain of unknown function (DUF1981) Totivirus_coat PF05518.9 MSTRG.5197.2_1 - 2.2 6.1 6.5 3.6 5.4 6.5 1.2 1 0 0 1 1 1 0 Totivirus coat protein BolA PF01722.16 MSTRG.25901.4_2 - 5.3e-20 71.4 0.1 9.4e-20 70.6 0.1 1.4 1 0 0 1 1 1 1 BolA-like protein GTP_EFTU PF00009.25 MSTRG.27424.1_3 - 1.6e-23 83.1 0.0 2.7e-23 82.4 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.23 MSTRG.27424.1_3 - 3.5e-07 30.4 0.1 9.6e-07 29.0 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.15 MSTRG.27424.1_3 - 0.00054 20.1 0.1 0.0019 18.4 0.1 2.0 1 1 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.21 MSTRG.27424.1_3 - 0.003 17.5 0.1 0.0067 16.4 0.1 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.7 MSTRG.27424.1_3 - 0.016 14.8 0.0 6.3 6.4 0.0 3.3 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Arf PF00025.19 MSTRG.27424.1_3 - 0.04 13.2 0.1 5 6.4 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family V-set PF07686.15 MSTRG.1080.1_2 - 2.4e-10 40.4 0.2 3.8e-06 26.9 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.23 MSTRG.1080.1_2 - 3.7e-08 33.3 1.8 0.00021 21.2 0.2 3.3 2 1 2 4 4 4 2 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.1080.1_2 - 7.7e-07 29.5 1.6 0.0076 16.7 0.9 3.6 2 1 1 3 3 3 2 Immunoglobulin domain I-set PF07679.14 MSTRG.1080.1_2 - 5.4e-06 26.3 0.1 0.03 14.3 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set_CD47 PF08204.9 MSTRG.1080.1_2 - 0.0009 19.1 0.2 0.096 12.5 0.2 2.6 2 1 0 2 2 2 1 CD47 immunoglobulin-like domain Ig_2 PF13895.4 MSTRG.1080.1_2 - 0.0018 18.5 0.3 5.5 7.3 0.1 3.5 3 1 0 3 3 3 2 Immunoglobulin domain Izumo-Ig PF16706.3 MSTRG.1080.1_2 - 0.0096 15.8 0.2 0.71 9.8 0.0 2.6 2 1 0 2 2 2 1 Izumo-like Immunoglobulin domain zf-C3HC4_2 PF13923.4 MSTRG.27672.1_3 - 2.8e-10 39.7 9.6 6.2e-10 38.6 9.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 MSTRG.27672.1_3 - 2.5e-08 33.5 10.4 2.5e-08 33.5 10.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 MSTRG.27672.1_3 - 8.9e-08 31.7 6.5 8.9e-08 31.7 6.5 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.27672.1_3 - 9.7e-08 32.0 10.2 2.6e-07 30.7 10.2 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.4 MSTRG.27672.1_3 - 2e-07 30.8 5.0 2.2e-07 30.6 3.3 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 MSTRG.27672.1_3 - 1.6e-05 24.8 10.0 3.5e-05 23.7 10.0 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.5 MSTRG.27672.1_3 - 0.00054 20.1 10.9 0.0024 18.0 10.9 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.4 MSTRG.27672.1_3 - 0.0014 18.4 9.4 0.004 17.0 9.4 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.5 MSTRG.27672.1_3 - 0.012 15.5 2.4 0.03 14.3 2.4 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.4 MSTRG.27672.1_3 - 0.15 11.8 11.7 0.82 9.5 11.6 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_6 PF14835.4 MSTRG.27672.1_3 - 0.33 10.7 4.7 0.29 10.9 2.4 2.1 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.4 MSTRG.27672.1_3 - 0.42 10.2 10.2 1.5 8.4 10.2 2.0 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Syndecan PF01034.18 MSTRG.9610.1_1 - 4.2e-29 100.1 0.0 8.4e-29 99.2 0.0 1.5 1 0 0 1 1 1 1 Syndecan domain Carb_anhydrase PF00194.19 MSTRG.22028.2_3 - 2.5e-84 282.7 0.0 3.4e-84 282.2 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase PSI PF01437.23 MSTRG.26754.1_1 - 6.7e-14 52.0 35.5 6.1e-08 33.0 15.1 2.6 2 0 0 2 2 2 2 Plexin repeat Smac_DIABLO PF09057.8 MSTRG.26754.1_1 - 0.087 12.0 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Second Mitochondria-derived Activator of Caspases PSI_integrin PF17205.1 MSTRG.26754.1_1 - 0.11 12.2 28.4 1.3 8.8 9.8 2.7 2 1 0 2 2 2 0 Integrin plexin domain Myb_DNA-bind_5 PF13873.4 MSTRG.2288.1_3 - 4.9e-26 90.5 5.0 8.9e-26 89.6 5.0 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.7 MSTRG.2288.1_3 - 0.0004 20.5 0.1 0.001 19.2 0.1 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like TBCA PF02970.14 MSTRG.2288.1_3 - 0.27 11.5 6.7 0.071 13.3 1.2 2.3 2 0 0 2 2 2 0 Tubulin binding cofactor A Myb_DNA-bind_3 PF12776.5 MSTRG.2288.1_3 - 0.47 11.2 3.0 0.48 11.1 0.2 2.3 2 1 1 3 3 3 0 Myb/SANT-like DNA-binding domain DUF1043 PF06295.10 MSTRG.2288.1_3 - 1.1 9.1 7.0 4.4 7.2 0.4 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1043) BTB_3 PF16017.3 MSTRG.17375.2_2 - 1.7e-50 169.4 0.0 2.9e-50 168.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB_2 PF02214.20 MSTRG.17375.2_2 - 0.002 18.3 0.0 0.004 17.4 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Reticulon PF02453.15 MSTRG.3820.1_2 - 2.1e-32 112.1 10.6 3.9e-32 111.2 10.6 1.4 1 0 0 1 1 1 1 Reticulon TACC PF05010.12 MSTRG.7535.1_3 - 1.4e-75 253.4 34.8 2e-75 252.9 34.8 1.2 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC) DUF3584 PF12128.6 MSTRG.7535.1_3 - 0.27 8.5 27.3 0.49 7.7 27.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) GLTSCR1 PF15249.4 MSTRG.7535.1_3 - 0.48 10.8 9.5 0.19 12.1 2.4 2.8 2 0 0 2 2 2 0 Conserved region of unknown function on GLTSCR protein Pkinase_Tyr PF07714.15 MSTRG.16699.1_1 - 1.9e-99 332.0 0.0 5.2e-99 330.6 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.16699.1_1 - 6.2e-48 163.3 0.0 1.2e-47 162.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 MSTRG.16699.1_1 - 8.3e-23 80.1 0.1 9.4e-22 76.8 0.1 2.4 2 0 0 2 2 2 1 SH2 domain FCH PF00611.21 MSTRG.16699.1_1 - 6.7e-09 35.8 1.9 6.7e-09 35.8 1.9 2.2 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain Cgr1 PF03879.12 MSTRG.16699.1_1 - 1.9 8.8 9.3 4.6 7.5 9.3 1.6 1 0 0 1 1 1 0 Cgr1 family VWA_2 PF13519.4 MSTRG.19141.2_3 - 6.2e-06 26.7 0.0 1.7e-05 25.3 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.26 MSTRG.19141.2_3 - 0.00036 20.7 0.1 0.00086 19.5 0.1 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain Het-C PF07217.9 MSTRG.19141.2_3 - 0.00044 18.8 0.0 0.00065 18.2 0.0 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C HLH PF00010.24 MSTRG.26667.4_2 - 1.9e-13 50.0 0.0 3.6e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF3371 PF11851.6 MSTRG.26667.4_2 - 4.9e-06 27.5 0.3 1.5e-05 25.9 0.2 1.9 2 1 0 2 2 2 1 Domain of unknown function (DUF3371) HLH PF00010.24 MSTRG.26667.4_3 - 0.0056 16.5 4.6 0.011 15.6 4.6 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Fusion_F0 PF13044.4 MSTRG.27920.2_1 - 0.19 10.2 0.0 0.28 9.7 0.0 1.1 1 0 0 1 1 1 0 Fusion glycoprotein F0, Isavirus ANF_receptor PF01094.26 MSTRG.27920.2_3 - 0.00021 20.4 0.1 0.00029 19.9 0.1 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region SUI1 PF01253.20 MSTRG.5352.1_1 - 1.8e-24 85.9 0.7 2.9e-24 85.3 0.7 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 SUI1 PF01253.20 MSTRG.5352.1_3 - 0.00039 20.8 0.0 0.00063 20.1 0.0 1.3 1 0 0 1 1 1 1 Translation initiation factor SUI1 Mannosyl_trans2 PF04188.11 MSTRG.17221.1_1 - 7.9e-117 391.1 15.9 1e-116 390.7 15.9 1.1 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V) SH2 PF00017.22 MSTRG.19215.1_2 - 3.8e-10 39.5 0.0 6.8e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.14 MSTRG.19215.1_2 - 0.00013 22.1 0.0 0.00036 20.7 0.0 1.8 1 0 0 1 1 1 1 SOCS box Endonuclease_NS PF01223.21 MSTRG.21212.4_1 - 1.4e-25 90.3 4.3 5.1e-25 88.5 4.3 1.7 1 1 0 1 1 1 1 DNA/RNA non-specific endonuclease Endonuclea_NS_2 PF13930.4 MSTRG.21212.4_1 - 0.039 13.9 0.1 0.068 13.1 0.1 1.4 1 0 0 1 1 1 0 DNA/RNA non-specific endonuclease SPO22 PF08631.8 MSTRG.8009.1_2 - 3.7e-05 23.2 1.8 5.2e-05 22.7 1.8 1.3 1 0 0 1 1 1 1 Meiosis protein SPO22/ZIP4 like HECT PF00632.23 MSTRG.15124.6_1 - 7e-101 337.6 0.1 1e-100 337.1 0.1 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.24 MSTRG.15124.6_1 - 6.1e-38 128.3 18.0 2.9e-12 46.2 4.4 3.8 3 0 0 3 3 3 3 WW domain WW PF00397.24 MSTRG.15124.6_2 - 7.1e-12 44.9 1.6 1.6e-11 43.8 1.6 1.7 1 0 0 1 1 1 1 WW domain Ig_3 PF13927.4 MSTRG.21142.3_1 - 3.9e-31 107.3 10.7 3.9e-05 24.0 0.0 6.0 6 0 0 6 6 6 5 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.21142.3_1 - 7.3e-24 83.8 3.8 8.4e-07 29.1 0.0 5.5 6 0 0 6 6 6 4 Immunoglobulin domain C2-set_2 PF08205.10 MSTRG.21142.3_1 - 6.6e-22 77.3 4.0 4.2e-14 52.2 0.0 5.3 5 1 1 6 6 6 2 CD80-like C2-set immunoglobulin domain I-set PF07679.14 MSTRG.21142.3_1 - 2.2e-20 72.3 8.1 0.00023 21.0 0.0 7.2 5 3 0 5 5 5 5 Immunoglobulin I-set domain ig PF00047.23 MSTRG.21142.3_1 - 8.6e-13 48.1 10.0 0.017 15.1 0.4 6.8 5 1 0 5 5 5 4 Immunoglobulin domain V-set PF07686.15 MSTRG.21142.3_1 - 2.8e-11 43.4 11.3 9.2e-07 28.9 0.1 5.5 4 2 2 6 6 6 2 Immunoglobulin V-set domain C1-set PF07654.13 MSTRG.21142.3_1 - 1e-05 25.7 6.1 0.019 15.3 0.0 4.1 5 1 0 5 5 5 2 Immunoglobulin C1-set domain TMEM154 PF15102.4 MSTRG.21142.3_1 - 0.0067 16.2 0.7 0.014 15.1 0.7 1.5 1 0 0 1 1 1 1 TMEM154 protein family MGC-24 PF05283.9 MSTRG.21142.3_1 - 0.012 16.0 1.1 0.033 14.5 1.1 1.8 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin COX2_TM PF02790.13 MSTRG.21142.3_1 - 0.013 15.5 0.1 1.2 9.3 0.1 2.5 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain DUF4366 PF14283.4 MSTRG.21142.3_1 - 0.041 13.2 0.1 0.077 12.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) PDZ PF00595.22 MSTRG.2252.1_2 - 4e-73 241.6 4.2 5e-19 68.3 0.0 4.4 4 0 0 4 4 4 4 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.2252.1_2 - 5.7e-21 74.5 0.3 7.9e-08 32.4 0.0 4.6 4 0 0 4 4 4 4 PDZ domain DUF3338 PF11819.6 MSTRG.12506.1_1 - 1.6e-55 186.7 1.7 1.6e-55 186.7 1.7 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF3338) BAR_3 PF16746.3 MSTRG.27563.1_2 - 7.2e-83 277.8 19.7 1e-82 277.3 19.7 1.2 1 0 0 1 1 1 1 BAR domain of APPL family RhoGAP PF00620.25 MSTRG.27563.1_2 - 5e-41 139.9 0.3 1.8e-40 138.1 0.0 2.0 3 0 0 3 3 3 1 RhoGAP domain SH3_9 PF14604.4 MSTRG.27563.1_2 - 3.9e-12 45.7 0.0 6.9e-12 44.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.27 MSTRG.27563.1_2 - 8.9e-08 32.5 0.0 3.3e-07 30.6 0.0 2.0 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.26 MSTRG.27563.1_2 - 2.4e-07 30.1 0.0 4e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.27563.1_2 - 3.7e-07 29.6 0.0 9.9e-07 28.2 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Arfaptin PF06456.11 MSTRG.27563.1_2 - 5.6e-05 22.7 12.2 5.6e-05 22.7 12.2 1.7 2 0 0 2 2 2 1 Arfaptin-like domain BAR PF03114.16 MSTRG.27563.1_2 - 0.00012 21.7 14.6 0.00012 21.7 14.6 1.7 1 1 1 2 2 2 1 BAR domain IMD PF08397.9 MSTRG.27563.1_2 - 0.0014 18.0 10.5 0.0029 16.9 8.2 2.4 3 0 0 3 3 3 1 IRSp53/MIM homology domain BAG PF02179.14 MSTRG.27563.1_2 - 0.023 15.0 1.5 0.075 13.3 1.5 1.9 1 0 0 1 1 1 0 BAG domain DUF3987 PF13148.4 MSTRG.27563.1_2 - 0.11 11.3 3.6 0.2 10.5 3.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) RSN1_7TM PF02714.13 MSTRG.15081.1_2 - 1e-53 182.3 23.4 2.6e-53 181.0 23.4 1.7 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.4 MSTRG.15081.1_2 - 3.1e-40 138.2 0.1 4.4e-40 137.7 0.1 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.4 MSTRG.15081.1_2 - 1.5e-21 76.6 2.9 1.5e-21 76.6 2.9 4.7 5 2 0 5 5 5 1 Late exocytosis, associated with Golgi transport RRM_1 PF00076.20 MSTRG.15081.1_2 - 0.0059 16.3 0.0 0.53 10.0 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) V-set PF07686.15 MSTRG.77.1_3 - 2.9e-09 36.9 0.0 4.9e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 MSTRG.77.1_3 - 0.00028 21.3 0.0 0.0012 19.2 0.0 2.1 2 1 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 MSTRG.77.1_3 - 0.00049 20.0 0.0 0.0012 18.7 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 MSTRG.77.1_3 - 0.00064 19.7 0.0 0.0045 17.0 0.0 2.3 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.77.1_3 - 0.012 15.8 0.0 0.055 13.7 0.0 2.0 1 1 0 1 1 1 0 Immunoglobulin domain TSP_3 PF02412.16 MSTRG.3659.1_2 - 6.5e-55 182.4 95.1 1.5e-15 56.5 7.6 7.7 6 1 1 7 7 7 7 Thrombospondin type 3 repeat TSP_C PF05735.10 MSTRG.3659.1_2 - 1.1e-48 165.7 0.6 1.4e-48 165.3 0.6 1.1 1 0 0 1 1 1 1 Thrombospondin C-terminal region Fer4_13 PF13370.4 MSTRG.3659.1_2 - 0.085 13.3 9.8 5 7.6 0.0 4.2 5 0 0 5 5 5 0 4Fe-4S single cluster domain of Ferredoxin I TB PF00683.15 MSTRG.3659.1_2 - 0.54 9.9 4.2 5.8 6.6 0.1 3.2 3 0 0 3 3 3 0 TB domain BNIP2 PF12496.6 MSTRG.3659.1_2 - 4.2 7.6 12.5 0.54 10.5 4.3 2.4 1 1 1 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 MBT PF02820.16 MSTRG.3659.1_3 - 0.12 12.6 0.0 0.21 11.8 0.0 1.3 1 0 0 1 1 1 0 mbt repeat Cast PF10174.7 MSTRG.17319.1_3 - 0.23 9.5 36.6 0.0052 14.9 3.6 2.5 1 1 1 2 2 2 0 RIM-binding protein of the cytomatrix active zone Spc7 PF08317.9 MSTRG.17319.1_3 - 0.77 8.4 39.6 0.56 8.9 6.0 3.2 1 1 2 3 3 3 0 Spc7 kinetochore protein KASH_CCD PF14662.4 MSTRG.17319.1_3 - 2.8 7.6 39.7 19 4.9 32.6 2.5 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Tropomyosin_1 PF12718.5 MSTRG.17319.1_3 - 3.2 7.8 41.0 0.27 11.2 26.6 3.1 2 1 1 3 3 3 0 Tropomyosin like ARA70 PF12489.6 MSTRG.17319.1_3 - 9.4 6.3 13.0 0.52 10.4 7.2 1.9 2 0 0 2 2 2 0 Nuclear coactivator FBD PF08387.8 MSTRG.28198.1_3 - 0.045 13.5 0.0 0.068 12.9 0.0 1.3 1 0 0 1 1 1 0 FBD PilI PF10623.7 MSTRG.28198.1_3 - 0.075 13.0 0.1 0.087 12.9 0.1 1.1 1 0 0 1 1 1 0 Plasmid conjugative transfer protein PilI GST_N PF02798.18 MSTRG.4702.7_3 - 7.1e-13 48.6 0.0 1.3e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.4 MSTRG.4702.7_3 - 1e-11 44.9 0.0 1.6e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 MSTRG.4702.7_3 - 3.6e-10 39.9 0.0 5.7e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain PAPS_reduct PF01507.17 MSTRG.12534.3_3 - 1e-28 100.4 0.0 2.7e-26 92.5 0.0 2.3 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family MoCF_biosynth PF00994.22 MSTRG.12534.3_3 - 1.4e-28 99.3 0.0 2.3e-28 98.5 0.0 1.3 1 0 0 1 1 1 1 Probable molybdopterin binding domain Pyrid_oxidase_2 PF13883.4 MSTRG.26762.1_3 - 7.1e-56 188.7 0.0 8.9e-56 188.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase DUF3855 PF12967.5 MSTRG.26762.1_3 - 0.19 11.5 0.0 0.3 10.9 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3855) UPA PF17217.1 MSTRG.6252.3_3 - 1.1e-68 229.6 0.6 1.7e-68 229.0 0.6 1.2 1 0 0 1 1 1 1 UPA domain ZU5 PF00791.18 MSTRG.6252.3_3 - 8.9e-25 86.8 0.0 4.6e-24 84.5 0.0 2.2 2 0 0 2 2 2 1 ZU5 domain Death PF00531.20 MSTRG.6252.3_3 - 0.01 15.9 0.1 0.033 14.2 0.0 1.9 2 0 0 2 2 2 0 Death domain YCF90 PF17088.3 MSTRG.27121.1_3 - 0.059 12.5 0.1 0.07 12.3 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family MTBP_N PF14918.4 MSTRG.27121.1_3 - 0.12 11.7 0.1 0.13 11.5 0.1 1.1 1 0 0 1 1 1 0 MDM2-binding Peptidase_M10 PF00413.22 MSTRG.16133.1_3 - 9.7e-59 197.6 0.0 9.7e-59 197.6 0.0 1.6 2 0 0 2 2 2 1 Matrixin Hemopexin PF00045.17 MSTRG.16133.1_3 - 6.3e-50 166.8 20.1 6.9e-15 54.6 2.1 4.5 4 0 0 4 4 4 4 Hemopexin DUF3377 PF11857.6 MSTRG.16133.1_3 - 2.5e-30 104.1 0.6 6.4e-30 102.8 0.6 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) PG_binding_1 PF01471.16 MSTRG.16133.1_3 - 5.9e-09 35.9 0.0 1.1e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.22 MSTRG.16133.1_3 - 0.0049 16.4 0.7 0.75 9.2 0.1 2.2 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) DUF912 PF06024.10 MSTRG.16133.1_3 - 0.0093 16.1 0.1 0.028 14.6 0.0 1.8 2 0 0 2 2 2 1 Nucleopolyhedrovirus protein of unknown function (DUF912) TMEM154 PF15102.4 MSTRG.16133.1_3 - 0.037 13.8 0.0 0.069 12.9 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family Metallopep PF12044.6 MSTRG.16133.1_3 - 0.091 11.2 0.0 0.13 10.7 0.0 1.1 1 0 0 1 1 1 0 Putative peptidase family Pes-10 PF07149.9 MSTRG.16133.1_3 - 2.6 6.9 4.9 3.6 6.4 4.9 1.1 1 0 0 1 1 1 0 Pes-10 Reprolysin_3 PF13582.4 MSTRG.16133.1_3 - 3.5 8.0 5.5 0.24 11.8 0.2 1.7 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like DUF1331 PF07048.9 MSTRG.15936.1_3 - 0.1 12.2 0.6 0.4 10.2 0.6 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1331) Gcd10p PF04189.11 MSTRG.24722.1_3 - 1.6e-73 247.4 0.0 2.3e-73 246.8 0.0 1.3 1 0 0 1 1 1 1 Gcd10p family Sigma70_ner PF04546.11 MSTRG.24722.1_3 - 0.011 15.5 6.8 0.48 10.1 0.4 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region Collagen PF01391.16 MSTRG.4521.1_3 - 8.1e-17 60.6 99.4 1.4e-09 37.4 41.9 3.3 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Fer2 PF00111.25 MSTRG.27887.1_1 - 4.3e-10 39.3 0.0 9.2e-10 38.2 0.0 1.5 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain DnaJ PF00226.29 MSTRG.13810.1_1 - 8.9e-21 73.7 4.1 2e-20 72.5 1.1 2.2 2 0 0 2 2 2 1 DnaJ domain Carb_anhydrase PF00194.19 MSTRG.3204.1_2 - 6.6e-89 297.7 0.1 9.3e-89 297.2 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Pentaxin PF00354.15 MSTRG.3204.1_2 - 6e-34 117.3 0.5 1e-33 116.5 0.5 1.3 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.4 MSTRG.3204.1_2 - 7e-11 42.4 0.3 1.2e-10 41.6 0.3 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Thioredoxin_6 PF13848.4 MSTRG.1121.2_3 - 7.1e-10 39.0 0.0 1.1e-09 38.4 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain Trypan_PARP PF05887.9 MSTRG.1121.2_3 - 0.95 9.4 14.0 1.8 8.5 14.0 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Nebulin PF00880.16 MSTRG.1479.8_1 - 0 1759.7 622.8 2.7e-10 39.9 2.0 148.1 154 0 0 154 154 154 117 Nebulin repeat Peptidase_M24 PF00557.22 MSTRG.1479.8_1 - 4e-16 59.2 3.1 0.3 10.6 0.0 10.4 10 0 0 10 10 10 6 Metallopeptidase family M24 SH3_1 PF00018.26 MSTRG.1479.8_1 - 3.1e-12 45.7 0.0 1.6e-11 43.5 0.0 2.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.1479.8_1 - 3.6e-12 45.8 0.0 7.8e-12 44.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.1479.8_1 - 1e-05 25.0 0.0 8.3e-05 22.1 0.0 2.7 2 0 0 2 2 2 1 Variant SH3 domain Toprim_2 PF13155.4 MSTRG.1479.8_1 - 0.48 10.8 7.6 72 3.8 0.0 6.1 6 0 0 6 6 6 0 Toprim-like zf-H2C2_2 PF13465.4 MSTRG.232.1_3 - 1.3e-19 69.5 48.4 4.9e-07 29.8 4.2 6.4 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.232.1_3 - 1.1e-12 47.6 59.5 0.00013 22.1 3.9 6.7 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.232.1_3 - 3.6e-05 24.1 57.1 0.078 13.7 1.4 7.2 6 0 0 6 6 6 4 C2H2-type zinc finger zf-met PF12874.5 MSTRG.232.1_3 - 2.6 8.4 51.1 0.82 10.0 5.9 6.1 6 0 0 6 6 6 0 Zinc-finger of C2H2 type XK-related PF09815.7 MSTRG.15908.1_3 - 4.2e-75 252.7 25.6 5.7e-75 252.3 25.6 1.2 1 0 0 1 1 1 1 XK-related protein Lipase_GDSL PF00657.20 MSTRG.11979.1_2 - 8.8e-07 29.0 0.0 8.8e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase EBP PF05241.10 MSTRG.20246.1_2 - 8.2e-54 181.6 15.0 1.4e-53 180.9 15.0 1.3 1 0 0 1 1 1 1 Emopamil binding protein DUF788 PF05620.9 MSTRG.20246.1_2 - 3.4 7.4 7.1 1.5 8.5 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF788) Thioredoxin PF00085.18 MSTRG.9794.1_2 - 1.4e-64 214.4 0.0 1.2e-31 108.6 0.0 3.5 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.4 MSTRG.9794.1_2 - 2.2e-38 131.9 0.0 1.2e-30 106.7 0.1 2.5 3 0 0 3 3 3 2 Thioredoxin-like domain Calsequestrin PF01216.15 MSTRG.9794.1_2 - 7.3e-07 28.4 0.0 1.1e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Calsequestrin Thioredoxin_8 PF13905.4 MSTRG.9794.1_2 - 1.5e-06 28.3 0.0 0.088 13.0 0.0 3.9 3 1 1 4 4 4 2 Thioredoxin-like Thioredoxin_7 PF13899.4 MSTRG.9794.1_2 - 1.7e-06 28.0 0.0 0.032 14.3 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.4 MSTRG.9794.1_2 - 9.2e-06 25.9 2.6 0.4 11.0 0.1 4.7 4 2 0 4 4 4 2 Thioredoxin-like domain OST3_OST6 PF04756.11 MSTRG.9794.1_2 - 0.00026 20.3 0.2 0.66 9.1 0.0 2.8 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family AhpC-TSA PF00578.19 MSTRG.9794.1_2 - 0.00093 19.0 0.2 1.6 8.5 0.0 2.7 3 0 0 3 3 3 2 AhpC/TSA family Thioredoxin_4 PF13462.4 MSTRG.9794.1_2 - 0.0036 17.3 0.0 1.5 8.8 0.0 3.5 2 1 0 3 3 3 1 Thioredoxin Thioredoxin_3 PF13192.4 MSTRG.9794.1_2 - 0.016 15.1 0.1 1.7 8.6 0.0 3.1 3 0 0 3 3 3 0 Thioredoxin domain HMG-CoA_red PF00368.16 MSTRG.26846.1_3 - 3.1e-149 496.8 1.1 3.9e-149 496.5 1.1 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Sterol-sensing PF12349.6 MSTRG.26846.1_3 - 6.7e-18 64.8 4.4 1.3e-17 63.9 4.4 1.5 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.16 MSTRG.26846.1_3 - 1.7e-09 36.2 3.2 2.5e-09 35.7 3.2 1.1 1 0 0 1 1 1 1 Patched family Trypsin PF00089.24 MSTRG.14769.1_3 - 2.6e-66 223.5 0.7 3.3e-66 223.1 0.7 1.1 1 0 0 1 1 1 1 Trypsin Kringle PF00051.16 MSTRG.14769.1_3 - 3.7e-21 75.1 2.4 8.7e-21 73.9 2.4 1.7 1 0 0 1 1 1 1 Kringle domain EGF PF00008.25 MSTRG.14769.1_3 - 7.7e-12 45.1 26.5 1.7e-07 31.3 9.0 4.8 5 0 0 5 5 5 3 EGF-like domain EGF_2 PF07974.11 MSTRG.14769.1_3 - 0.001 19.2 44.9 0.087 13.1 11.2 4.4 3 0 0 3 3 3 2 EGF-like domain hEGF PF12661.5 MSTRG.14769.1_3 - 0.0011 19.4 5.4 0.0011 19.4 5.4 5.5 6 0 0 6 6 6 2 Human growth factor-like EGF FAP PF07174.9 MSTRG.14769.1_3 - 0.34 10.2 16.4 0.66 9.2 16.4 1.4 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Katanin_con80 PF13925.4 MSTRG.15299.2_2 - 2.5e-32 112.0 0.1 4.2e-32 111.3 0.1 1.4 1 0 0 1 1 1 1 con80 domain of Katanin PsbJ PF01788.15 MSTRG.5138.2_1 - 0.058 13.2 0.2 0.12 12.1 0.2 1.5 1 0 0 1 1 1 0 PsbJ SelR PF01641.16 MSTRG.5138.2_2 - 1.8e-52 176.3 0.3 2.6e-52 175.9 0.3 1.2 1 0 0 1 1 1 1 SelR domain MEA1 PF06910.9 MSTRG.26272.1_1 - 3.4e-39 134.1 7.4 5.3e-39 133.5 7.4 1.2 1 0 0 1 1 1 1 Male enhanced antigen 1 (MEA1) RhoGAP PF00620.25 MSTRG.15146.2_1 - 2.4e-47 160.4 0.0 4.2e-47 159.6 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.27 MSTRG.15146.2_1 - 6.6e-20 71.4 0.3 1.8e-19 70.1 0.0 1.8 2 0 0 2 2 2 1 PH domain PH_11 PF15413.4 MSTRG.15146.2_1 - 6.3e-06 26.4 1.2 0.00053 20.2 0.2 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain ATG16 PF08614.9 MSTRG.15146.2_1 - 0.0021 18.1 2.6 0.0036 17.4 2.6 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Tropomyosin_1 PF12718.5 MSTRG.15146.2_1 - 0.092 12.7 8.9 0.25 11.3 8.9 1.6 1 0 0 1 1 1 0 Tropomyosin like ADIP PF11559.6 MSTRG.15146.2_1 - 0.11 12.5 9.8 0.2 11.6 9.8 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding IncA PF04156.12 MSTRG.15146.2_1 - 0.17 11.5 4.5 0.31 10.7 4.5 1.3 1 0 0 1 1 1 0 IncA protein DUF4472 PF14739.4 MSTRG.15146.2_1 - 0.31 11.6 8.3 0.57 10.8 8.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) CALCOCO1 PF07888.9 MSTRG.15146.2_1 - 0.54 8.6 7.4 0.79 8.1 7.4 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DMPK_coil PF08826.8 MSTRG.15146.2_1 - 1 9.4 14.3 1.2 9.2 6.9 2.5 1 1 1 2 2 2 0 DMPK coiled coil domain like B56 PF01603.18 MSTRG.18341.2_1 - 1.1e-198 660.2 12.2 1.3e-198 659.9 12.2 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) MIR PF02815.17 MSTRG.258.3_1 - 3.3e-12 46.5 0.1 7.3e-09 35.6 0.0 2.1 1 1 1 2 2 2 2 MIR domain PIP5K PF01504.16 MSTRG.11593.1_2 - 1.5e-42 145.6 0.2 8e-33 113.7 0.2 2.9 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.22 MSTRG.11593.1_2 - 3e-32 111.8 0.5 4.7e-32 111.1 0.5 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DEP PF00610.19 MSTRG.11593.1_2 - 7.1e-18 64.3 0.0 1.6e-17 63.2 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FYVE PF01363.19 MSTRG.11593.1_2 - 2e-15 56.5 13.1 2e-15 56.5 13.1 2.4 2 0 0 2 2 2 1 FYVE zinc finger DHHA2 PF02833.12 MSTRG.3649.1_1 - 3.5e-24 85.4 0.0 5.2e-24 84.9 0.0 1.3 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.18 MSTRG.3649.1_1 - 2.5e-11 43.6 0.0 4.1e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 DHH family Med25_VWA PF11265.6 MSTRG.19442.3_1 - 4.3e-81 271.7 0.0 8.3e-81 270.8 0.0 1.5 1 0 0 1 1 1 1 Mediator complex subunit 25 von Willebrand factor type A Med25 PF11232.6 MSTRG.19442.3_1 - 8.8e-59 197.7 0.3 1.3e-58 197.1 0.3 1.3 1 0 0 1 1 1 1 Mediator complex subunit 25 PTOV activation and synapsin 2 Med25_NR-box PF11244.6 MSTRG.19442.3_1 - 2e-08 34.4 18.9 2e-08 34.4 18.9 4.1 3 1 1 4 4 4 1 Mediator complex subunit 25 C-terminal NR box-containing Y_phosphatase PF00102.25 MSTRG.14807.1_3 - 6.5e-13 48.7 0.0 7.5e-13 48.4 0.0 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase MIIP PF15734.3 MSTRG.21022.1_1 - 8.3e-81 272.1 9.2 1.2e-80 271.6 9.2 1.1 1 0 0 1 1 1 1 Migration and invasion-inhibitory Mcl1_mid PF12341.6 MSTRG.25030.2_1 - 0.035 13.3 0.1 0.064 12.4 0.1 1.3 1 0 0 1 1 1 0 Minichromosome loss protein, Mcl1, middle region ANAPC4_WD40 PF12894.5 MSTRG.25030.2_1 - 0.039 14.1 0.1 0.21 11.8 0.1 2.2 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain SIT PF15330.4 MSTRG.19787.1_2 - 0.011 16.0 0.1 0.017 15.4 0.1 1.2 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT TMEM132D_C PF15706.3 MSTRG.19787.1_2 - 0.15 11.7 0.3 0.38 10.4 0.2 1.8 1 1 1 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term zf-C2H2 PF00096.24 MSTRG.24169.1_3 - 4.3e-11 42.5 26.6 0.00012 22.2 2.7 4.3 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.24169.1_3 - 8.8e-08 32.2 25.9 0.0014 19.2 2.0 4.4 4 0 0 4 4 4 3 C2H2-type zinc finger zf-H2C2_2 PF13465.4 MSTRG.24169.1_3 - 3.2e-05 24.1 21.7 0.0069 16.7 1.2 5.1 5 0 0 5 5 5 2 Zinc-finger double domain Zn-ribbon_8 PF09723.8 MSTRG.24169.1_3 - 0.0019 18.2 5.3 0.34 10.9 3.6 2.5 2 0 0 2 2 2 2 Zinc ribbon domain zf-C2H2_jaz PF12171.6 MSTRG.24169.1_3 - 0.053 13.7 0.6 0.053 13.7 0.6 3.3 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding CpXC PF14353.4 MSTRG.24169.1_3 - 0.17 11.8 9.8 1.8 8.5 0.2 3.0 1 1 1 2 2 2 0 CpXC protein zf-C2H2_2 PF12756.5 MSTRG.24169.1_3 - 0.22 11.7 18.2 0.53 10.5 1.2 3.4 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) DZR PF12773.5 MSTRG.24169.1_3 - 0.72 9.8 6.8 2.1 8.3 6.8 1.9 1 1 0 1 1 1 0 Double zinc ribbon zf-C2H2_9 PF16293.3 MSTRG.24169.1_3 - 1 9.1 6.0 23 4.8 0.1 3.3 2 1 1 3 3 3 0 C2H2 type zinc-finger (1 copy) DUF2256 PF10013.7 MSTRG.24169.1_3 - 2.5 8.2 6.3 2.4 8.2 0.1 3.2 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) HNH PF01844.21 MSTRG.24169.1_3 - 6.7 6.8 9.0 30 4.8 0.9 3.3 2 1 1 3 3 3 0 HNH endonuclease zf-LYAR PF08790.9 MSTRG.24169.1_3 - 9 6.2 9.4 9.7 6.1 0.5 2.9 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger UNC-93 PF05978.14 MSTRG.5288.1_1 - 4.1e-46 156.4 8.4 4.1e-46 156.4 8.4 2.1 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.14 MSTRG.5288.1_1 - 2.6e-11 42.9 36.0 2e-10 40.0 20.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MAM PF00629.21 MSTRG.13146.1_2 - 1.1e-14 54.5 0.1 1.1e-14 54.5 0.1 1.7 2 0 0 2 2 2 1 MAM domain, meprin/A5/mu MAM PF00629.21 MSTRG.13146.1_3 - 2.1e-140 463.2 1.2 4.6e-32 111.0 0.0 6.4 6 0 0 6 6 6 6 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.16 MSTRG.13146.1_3 - 7.8e-09 35.5 22.7 1.1e-07 31.8 10.3 2.9 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A Sugar_tr PF00083.22 MSTRG.8864.2_2 - 4.2e-09 35.6 0.0 5e-09 35.4 0.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter PhoLip_ATPase_C PF16212.3 MSTRG.513.1_2 - 8.7e-51 172.9 22.9 8.7e-51 172.9 22.9 2.5 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.3 MSTRG.513.1_2 - 3e-17 62.0 2.6 6.9e-17 60.8 2.6 1.6 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.24 MSTRG.513.1_2 - 4.3e-15 56.4 0.7 1.7e-12 47.9 0.7 3.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.18 MSTRG.513.1_2 - 3.2e-09 36.3 0.1 3.2e-09 36.3 0.1 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.4 MSTRG.513.1_2 - 3.7e-07 30.0 0.0 2.6e-06 27.3 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.10 MSTRG.513.1_2 - 0.018 14.7 0.0 0.043 13.4 0.0 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF4174 PF13778.4 MSTRG.513.1_2 - 0.038 14.4 0.1 0.086 13.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) GNVR PF13807.4 MSTRG.513.1_2 - 0.065 13.0 0.1 0.17 11.7 0.1 1.6 1 0 0 1 1 1 0 G-rich domain on putative tyrosine kinase DUF1664 PF07889.10 MSTRG.1604.1_2 - 0.2 11.5 0.4 0.22 11.4 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Mpp10 PF04006.10 MSTRG.28723.1_2 - 1e-41 143.0 10.3 1.1e-41 142.9 10.3 1.0 1 0 0 1 1 1 1 Mpp10 protein KAP_NTPase PF07693.12 MSTRG.17665.1_2 - 1.4e-105 353.1 0.1 2e-105 352.5 0.1 1.3 1 0 0 1 1 1 1 KAP family P-loop domain Ank_2 PF12796.5 MSTRG.17665.1_2 - 3.2e-72 239.0 4.0 1.1e-13 51.4 0.2 6.5 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.17665.1_2 - 2e-59 196.5 7.1 2.8e-11 43.3 0.2 10.4 2 1 8 10 10 10 10 Ankyrin repeats (many copies) Ank_4 PF13637.4 MSTRG.17665.1_2 - 3.9e-59 196.2 1.0 4.3e-09 36.6 0.0 8.9 3 2 8 11 11 11 10 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.17665.1_2 - 1.3e-53 177.1 0.3 2e-06 27.9 0.0 11.8 11 0 0 11 11 11 11 Ankyrin repeat Ank_3 PF13606.4 MSTRG.17665.1_2 - 2e-48 156.6 0.4 4.1e-06 26.6 0.0 12.0 11 0 0 11 11 11 11 Ankyrin repeat SAM_1 PF00536.28 MSTRG.17665.1_2 - 0.011 16.0 0.0 0.035 14.4 0.0 1.9 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) MgtE PF01769.14 MSTRG.17665.1_2 - 0.17 12.2 5.6 5.4 7.3 0.9 2.6 2 0 0 2 2 2 0 Divalent cation transporter Carn_acyltransf PF00755.18 MSTRG.22115.6_2 - 5.7e-132 441.1 0.0 7.4e-132 440.8 0.0 1.1 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase CPT_N PF16484.3 MSTRG.22115.6_2 - 9.4e-28 95.8 0.0 1.8e-27 94.9 0.0 1.5 1 0 0 1 1 1 1 Carnitine O-palmitoyltransferase N-terminus RRM_1 PF00076.20 MSTRG.13796.2_1 - 6.8e-14 51.3 0.0 1.1e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.13796.2_1 - 0.023 14.7 0.0 0.04 13.9 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif GST_C_2 PF13410.4 MSTRG.27663.1_2 - 0.0013 18.5 0.0 0.0044 16.8 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain YchF-GTPase_C PF06071.11 MSTRG.8818.1_3 - 2.2e-40 136.6 0.4 2.2e-40 136.6 0.4 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.21 MSTRG.8818.1_3 - 4.3e-23 81.5 0.0 1.7e-22 79.5 0.0 1.9 1 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.16 MSTRG.8818.1_3 - 2.1e-07 30.5 0.0 4.2e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B TGS PF02824.19 MSTRG.8818.1_3 - 0.00032 20.6 0.0 0.00081 19.3 0.0 1.6 1 0 0 1 1 1 1 TGS domain ArgK PF03308.14 MSTRG.8818.1_3 - 0.0067 15.3 0.0 0.012 14.4 0.0 1.4 1 0 0 1 1 1 1 ArgK protein Roc PF08477.11 MSTRG.8818.1_3 - 0.022 14.9 0.0 1 9.4 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.4 MSTRG.8818.1_3 - 0.064 13.6 0.0 0.49 10.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.21 MSTRG.8818.1_3 - 0.12 12.3 0.0 11 5.9 0.1 2.7 2 1 0 3 3 3 0 Dynamin family DAGK_cat PF00781.22 MSTRG.6861.3_2 - 7.6e-29 99.8 0.0 8.5e-28 96.4 0.0 2.1 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain UPRTase PF14681.4 MSTRG.7350.1_1 - 8.6e-53 178.7 0.0 1.4e-52 178.1 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.25 MSTRG.7350.1_1 - 0.0095 15.3 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain WD40 PF00400.30 MSTRG.16773.3_2 - 6.1e-24 83.7 13.5 2.1e-05 25.0 0.0 6.8 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.16773.3_2 - 0.0018 18.4 0.3 42 4.4 0.0 4.3 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain zf-CCCH_2 PF14608.4 MSTRG.16441.1_2 - 1.6e-09 37.8 68.9 3.6e-05 23.9 5.4 6.3 6 0 0 6 6 6 5 RNA-binding, Nab2-type zinc finger PWI PF01480.15 MSTRG.16441.1_2 - 0.054 13.7 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 PWI domain Kinesin PF00225.21 MSTRG.5793.2_1 - 5.8e-106 354.0 0.0 5.8e-106 354.0 0.0 1.6 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.3 MSTRG.5793.2_1 - 5.8e-22 78.1 0.4 1.3e-18 67.3 0.0 3.0 3 0 0 3 3 3 2 Microtubule binding MKLP1_Arf_bdg PF16540.3 MSTRG.5793.2_1 - 3.5e-06 26.9 0.0 1.3e-05 25.0 0.0 2.0 1 0 0 1 1 1 1 Arf6-interacting domain of mitotic kinesin-like protein 1 Vir_act_alpha_C PF10400.7 MSTRG.5793.2_1 - 0.83 10.2 5.5 0.62 10.7 1.8 2.6 2 0 0 2 2 2 0 Virulence activator alpha C-term TMF_DNA_bd PF12329.6 MSTRG.5793.2_1 - 5.1 7.0 21.8 0.3 11.0 12.3 3.0 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Dmrt1 PF12374.6 MSTRG.5793.2_1 - 5.4 7.4 6.3 30 5.0 2.7 3.5 3 1 0 3 3 3 0 Double-sex mab3 related transcription factor 1 DUF745 PF05335.11 MSTRG.5793.2_1 - 7.4 6.1 9.4 0.54 9.8 2.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Guanylate_kin PF00625.19 MSTRG.17253.1_1 - 1.4e-09 37.8 0.1 2.4e-09 37.0 0.1 1.4 1 1 0 1 1 1 1 Guanylate kinase SR-25 PF10500.7 MSTRG.17118.1_3 - 0.0057 16.2 29.1 0.0084 15.6 29.1 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein GCFC PF07842.10 MSTRG.5657.1_1 - 5.3e-98 327.9 14.2 5.3e-98 327.9 14.2 2.4 3 0 0 3 3 3 1 GC-rich sequence DNA-binding factor-like protein TIP_N PF12457.6 MSTRG.5657.1_1 - 2.9e-26 91.7 8.8 2.9e-26 91.7 8.8 2.0 2 0 0 2 2 2 1 Tuftelin interacting protein N terminal G-patch PF01585.21 MSTRG.5657.1_1 - 7.2e-17 60.9 4.4 1.7e-16 59.7 4.4 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.5 MSTRG.5657.1_1 - 0.00013 21.8 1.3 0.00036 20.4 1.3 1.7 1 0 0 1 1 1 1 G-patch domain PGA_cap PF09587.8 MSTRG.5657.1_1 - 0.022 14.1 0.2 0.049 12.9 0.2 1.5 1 0 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap betaPIX_CC PF16523.3 MSTRG.5657.1_1 - 0.045 13.4 0.1 0.14 11.9 0.1 1.8 1 0 0 1 1 1 0 betaPIX coiled coil zf-H2C2_2 PF13465.4 MSTRG.3694.2_2 - 6.5e-39 130.5 77.6 2.2e-07 30.9 0.2 12.1 12 0 0 12 12 12 9 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.3694.2_2 - 2.1e-35 119.1 77.8 3.2e-05 24.0 2.1 10.3 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.3694.2_2 - 1.3e-30 103.2 75.2 0.0017 18.9 1.8 10.3 10 0 0 10 10 10 10 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.3694.2_2 - 2.5e-14 53.0 31.4 0.07 13.3 0.1 9.5 9 0 0 9 9 9 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.3694.2_2 - 9.7e-12 44.7 58.0 0.0034 17.6 0.6 9.4 10 0 0 10 10 9 5 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 MSTRG.3694.2_2 - 2.6e-07 30.3 59.7 0.028 14.2 0.6 10.4 10 0 0 10 10 10 6 C2H2-type zinc finger FYVE PF01363.19 MSTRG.3694.2_2 - 0.0021 18.0 9.0 0.0021 18.0 9.0 6.1 2 1 3 5 5 5 2 FYVE zinc finger ADK_lid PF05191.12 MSTRG.3694.2_2 - 0.0028 17.5 2.3 0.0028 17.5 2.3 5.9 5 2 2 7 7 7 1 Adenylate kinase, active site lid zf-C2H2_11 PF16622.3 MSTRG.3694.2_2 - 0.038 13.6 1.0 0.038 13.6 1.0 8.9 10 0 0 10 10 10 0 zinc-finger C2H2-type Chordopox_A33R PF05966.10 MSTRG.3694.2_2 - 0.064 12.4 0.0 0.13 11.4 0.0 1.5 1 0 0 1 1 1 0 Chordopoxvirus A33R protein SPT6_acidic PF14632.4 MSTRG.3694.2_2 - 0.078 13.4 8.0 0.52 10.8 1.5 2.5 2 0 0 2 2 2 0 Acidic N-terminal SPT6 Peptidase_S68 PF10461.7 MSTRG.3694.2_2 - 0.12 12.4 1.0 0.91 9.6 1.0 2.6 1 0 0 1 1 1 0 Peptidase S68 Ta0938 PF11494.6 MSTRG.3694.2_2 - 2.9 8.1 10.8 1.5 9.0 0.1 4.5 2 2 6 8 8 7 0 Ta0938 Zn-ribbon_8 PF09723.8 MSTRG.3694.2_2 - 7.4 6.7 36.6 0.4 10.7 2.8 6.4 4 2 0 5 5 5 0 Zinc ribbon domain Phospholamban PF04272.12 MSTRG.20127.1_3 - 2.8e-30 103.4 4.9 5.3e-30 102.5 4.9 1.5 1 0 0 1 1 1 1 Phospholamban Sarcolipin PF05366.9 MSTRG.20127.1_3 - 0.00012 21.6 3.5 0.0002 20.8 3.5 1.4 1 0 0 1 1 1 1 Sarcolipin Pkinase PF00069.23 MSTRG.5237.1_3 - 1.4e-66 224.4 0.0 2e-66 223.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 MSTRG.5237.1_3 - 8.7e-46 153.8 0.0 1e-19 70.3 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Pkinase_Tyr PF07714.15 MSTRG.5237.1_3 - 8.5e-35 120.1 0.0 1.8e-34 119.1 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Ig_3 PF13927.4 MSTRG.5237.1_3 - 2.2e-30 104.9 0.2 7.9e-10 39.1 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.5237.1_3 - 3.3e-21 75.3 1.7 4.2e-08 33.3 0.2 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 MSTRG.5237.1_3 - 3.9e-18 65.3 2.0 2.9e-06 27.2 0.1 3.5 3 0 0 3 3 3 3 Immunoglobulin domain fn3 PF00041.19 MSTRG.5237.1_3 - 2.2e-12 47.0 0.0 4.7e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain V-set PF07686.15 MSTRG.5237.1_3 - 3.1e-06 27.2 1.8 1.6 8.8 0.1 5.1 3 3 0 3 3 3 2 Immunoglobulin V-set domain Interfer-bind PF09294.8 MSTRG.5237.1_3 - 0.0052 16.9 0.0 0.014 15.6 0.0 1.6 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III Kdo PF06293.12 MSTRG.5237.1_3 - 0.035 13.3 0.1 0.081 12.1 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 MSTRG.5237.1_3 - 0.08 12.4 0.1 0.34 10.4 0.0 1.7 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 zf-RING_2 PF13639.4 MSTRG.5571.1_1 - 3.9e-13 49.3 7.1 7.5e-13 48.4 7.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.5 MSTRG.5571.1_1 - 5.2e-10 39.3 5.0 1.1e-09 38.3 5.0 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.4 MSTRG.5571.1_1 - 3e-09 36.4 5.3 5.9e-09 35.5 5.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 MSTRG.5571.1_1 - 6e-08 32.1 4.0 6e-08 32.1 4.0 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.23 MSTRG.5571.1_1 - 5.2e-07 29.3 7.1 5.2e-07 29.3 7.1 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 MSTRG.5571.1_1 - 1.7e-05 24.6 1.7 3.2e-05 23.7 1.7 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.4 MSTRG.5571.1_1 - 4.1e-05 23.2 4.4 9.4e-05 22.1 4.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 MSTRG.5571.1_1 - 5.2e-05 23.0 6.1 5.2e-05 23.0 6.1 1.8 2 0 0 2 2 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 MSTRG.5571.1_1 - 0.0012 18.6 1.4 0.0019 18.1 0.6 1.8 1 1 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.4 MSTRG.5571.1_1 - 0.0038 16.9 6.7 0.008 15.9 6.7 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.4 MSTRG.5571.1_1 - 0.058 13.0 5.2 0.13 11.9 5.2 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-P11 PF03854.12 MSTRG.5571.1_1 - 0.13 11.8 0.9 0.31 10.6 0.9 1.5 1 0 0 1 1 1 0 P-11 zinc finger zf-RING-like PF08746.9 MSTRG.5571.1_1 - 0.23 11.6 6.3 0.47 10.7 6.3 1.5 1 0 0 1 1 1 0 RING-like domain Zn_ribbon_17 PF17120.3 MSTRG.5571.1_1 - 0.69 9.5 4.3 1.4 8.5 4.3 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.6 MSTRG.5571.1_1 - 3.2 7.9 6.5 17 5.5 6.5 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain SH3_1 PF00018.26 MSTRG.14219.1_1 - 4e-13 48.6 1.2 1.1e-08 34.4 0.0 2.4 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.4 MSTRG.14219.1_1 - 5.4e-13 48.5 0.1 3.4e-09 36.3 0.0 2.9 3 0 0 3 3 3 2 Variant SH3 domain SH3_2 PF07653.15 MSTRG.14219.1_1 - 7.6e-08 31.8 0.0 1.1e-06 28.1 0.0 2.4 2 0 0 2 2 2 1 Variant SH3 domain PX PF00787.22 MSTRG.14219.1_1 - 1.1e-07 31.7 0.4 3e-07 30.3 0.4 1.8 1 0 0 1 1 1 1 PX domain SH3_3 PF08239.9 MSTRG.14219.1_1 - 3.8e-06 26.9 0.5 0.0072 16.4 0.2 2.4 2 0 0 2 2 2 2 Bacterial SH3 domain hSH3 PF14603.4 MSTRG.14219.1_1 - 0.062 13.7 0.0 1.1 9.7 0.0 2.3 2 0 0 2 2 2 0 Helically-extended SH3 domain COMM_domain PF07258.12 MSTRG.1950.1_2 - 1e-16 60.6 1.4 2.3e-16 59.5 1.4 1.6 1 0 0 1 1 1 1 COMM domain zf-H2C2_2 PF13465.4 MSTRG.4273.4_1 - 3.9e-48 159.7 81.6 4e-09 36.4 0.1 12.3 12 0 0 12 12 12 8 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.4273.4_1 - 3.3e-36 121.6 100.2 1.1e-05 25.4 1.1 12.6 12 0 0 12 12 12 11 Zinc finger, C2H2 type TINF2_N PF14973.4 MSTRG.4273.4_1 - 2.9e-27 95.7 0.9 1.7e-15 57.5 0.0 2.6 2 0 0 2 2 2 2 TERF1-interacting nuclear factor 2 N-terminus zf-C2H2_4 PF13894.4 MSTRG.4273.4_1 - 8.2e-27 91.4 91.1 0.0027 18.3 1.8 12.7 12 0 0 12 12 12 11 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.4273.4_1 - 5.9e-08 32.3 87.9 0.056 13.3 0.3 12.4 12 0 0 12 12 12 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.4273.4_1 - 8.2e-08 32.2 60.0 0.34 11.1 0.1 12.3 12 0 0 12 12 12 6 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 MSTRG.4273.4_1 - 0.0021 18.0 46.9 0.58 10.2 1.1 7.7 5 4 4 9 9 9 7 Zinc ribbon domain BofA PF07441.9 MSTRG.5540.1_2 - 0.026 14.6 1.1 0.048 13.7 1.1 1.3 1 0 0 1 1 1 0 SigmaK-factor processing regulatory protein BofA Bombesin PF02044.15 MSTRG.5540.1_3 - 1.6e-08 33.9 3.1 3.8e-08 32.7 3.1 1.7 1 0 0 1 1 1 1 Bombesin-like peptide Actin PF00022.17 MSTRG.1592.2_2 - 1.1e-44 152.5 0.0 1.6e-42 145.4 0.0 2.6 1 1 0 1 1 1 1 Actin Asp PF00026.21 MSTRG.21228.1_3 - 3.6e-36 125.0 0.0 4.9e-36 124.6 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.4 MSTRG.21228.1_3 - 8e-13 48.3 0.0 1.2e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Synapsin_C PF02750.12 MSTRG.24759.1_1 - 3.8e-118 392.2 0.2 5.4e-118 391.7 0.2 1.2 1 0 0 1 1 1 1 Synapsin, ATP binding domain Synapsin PF02078.14 MSTRG.24759.1_1 - 3.4e-45 152.3 0.2 1.4e-44 150.4 0.1 2.0 2 0 0 2 2 2 1 Synapsin, N-terminal domain Synapsin_N PF10581.7 MSTRG.24759.1_1 - 2.8e-21 75.0 2.7 6.5e-21 73.9 2.7 1.6 1 0 0 1 1 1 1 Synapsin N-terminal RimK PF08443.9 MSTRG.24759.1_1 - 0.00092 18.7 0.0 0.012 15.1 0.0 2.1 2 0 0 2 2 2 1 RimK-like ATP-grasp domain SPX PF03105.17 MSTRG.6735.1_2 - 0.49 10.2 32.3 0.67 9.7 32.3 1.4 1 0 0 1 1 1 0 SPX domain PAW PF04721.15 MSTRG.10232.1_3 - 1.1e-69 234.1 0.5 1.6e-69 233.6 0.5 1.2 1 0 0 1 1 1 1 PNGase C-terminal domain, mannose-binding module PAW Rad4 PF03835.13 MSTRG.10232.1_3 - 1.3e-09 37.8 0.1 2.4e-09 36.9 0.1 1.3 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain SNF PF00209.16 MSTRG.26721.1_3 - 2.8e-14 52.6 0.2 3.3e-14 52.3 0.2 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Ribosomal_S8e PF01201.20 MSTRG.17134.1_1 - 1.3e-39 135.4 0.0 1.5e-39 135.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8e Sulfotransfer_2 PF03567.12 MSTRG.12478.2_3 - 3.2e-51 174.6 0.0 4.2e-51 174.1 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family C1-set PF07654.13 MSTRG.8514.1_3 - 9.4e-09 35.5 0.0 1.2e-08 35.2 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 MSTRG.8514.1_3 - 0.0036 17.7 0.0 0.005 17.3 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.8514.1_3 - 0.08 13.2 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin domain Pkinase_Tyr PF07714.15 MSTRG.8012.1_1 - 3.2e-101 337.9 0.0 4.4e-101 337.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.4 MSTRG.8012.1_1 - 1e-48 163.7 8.0 1.8e-12 47.5 0.0 6.9 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.14 MSTRG.8012.1_1 - 8.8e-42 141.0 0.1 1.3e-14 53.9 0.0 6.7 6 0 0 6 6 6 6 Immunoglobulin I-set domain Pkinase PF00069.23 MSTRG.8012.1_1 - 2.4e-41 141.7 0.0 2.5e-29 102.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ig_2 PF13895.4 MSTRG.8012.1_1 - 1.7e-31 108.2 14.1 8e-09 35.6 0.0 7.5 6 1 0 6 6 6 5 Immunoglobulin domain ig PF00047.23 MSTRG.8012.1_1 - 3e-23 81.7 13.2 1.4e-07 31.4 0.0 7.7 6 1 0 6 6 6 4 Immunoglobulin domain V-set PF07686.15 MSTRG.8012.1_1 - 3e-10 40.1 7.6 0.072 13.1 0.0 7.0 6 3 1 7 7 7 3 Immunoglobulin V-set domain Izumo-Ig PF16706.3 MSTRG.8012.1_1 - 8.6e-05 22.4 0.3 0.13 12.2 0.0 4.5 6 0 0 6 6 6 1 Izumo-like Immunoglobulin domain C2-set_2 PF08205.10 MSTRG.8012.1_1 - 0.00024 21.0 9.0 0.21 11.6 0.1 4.6 5 0 0 5 5 5 2 CD80-like C2-set immunoglobulin domain HMGL-like PF00682.17 MSTRG.12380.1_2 - 2.1e-68 230.6 0.0 2.5e-68 230.4 0.0 1.1 1 0 0 1 1 1 1 HMGL-like SBF2 PF12335.6 MSTRG.17388.3_1 - 1.6e-102 341.9 0.8 3.2e-102 340.9 0.8 1.6 1 0 0 1 1 1 1 Myotubularin protein Myotub-related PF06602.12 MSTRG.17388.3_1 - 2.6e-85 286.3 0.2 4.7e-85 285.4 0.2 1.4 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain PH PF00169.27 MSTRG.17388.3_1 - 1e-13 51.6 0.0 3.1e-13 50.0 0.0 1.9 2 0 0 2 2 2 1 PH domain GRAM PF02893.18 MSTRG.17388.3_1 - 1.3e-13 50.6 0.0 1.6e-12 47.1 0.0 2.5 2 0 0 2 2 2 1 GRAM domain PH_8 PF15409.4 MSTRG.17388.3_1 - 4.7e-05 23.5 0.0 0.00013 22.1 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_2 PF08458.8 MSTRG.17388.3_1 - 0.011 15.9 0.0 0.028 14.6 0.0 1.7 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PH_11 PF15413.4 MSTRG.17388.3_1 - 0.015 15.6 0.0 0.044 14.1 0.0 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain Sas10_Utp3 PF04000.13 MSTRG.18315.9_2 - 9.4e-17 61.3 0.1 1.3e-16 60.8 0.1 1.2 1 0 0 1 1 1 1 Sas10/Utp3/C1D family DUF932 PF06067.9 MSTRG.18315.9_2 - 0.055 13.1 0.2 0.089 12.4 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF932) NAD_binding_5 PF07994.10 MSTRG.8958.2_1 - 4.9e-140 466.3 0.0 6.1e-140 466.0 0.0 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.15 MSTRG.8958.2_1 - 2.2e-47 159.7 0.2 4.1e-47 158.8 0.2 1.5 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Peptidase_S3 PF00944.17 MSTRG.8958.2_1 - 0.0037 16.9 0.1 0.0067 16.1 0.1 1.3 1 0 0 1 1 1 1 Alphavirus core protein TMEM238 PF15125.4 MSTRG.19507.1_2 - 1.4e-20 73.1 10.8 3.1e-20 71.9 10.8 1.6 1 0 0 1 1 1 1 TMEM238 protein family pKID PF02173.15 MSTRG.19507.1_3 - 0.4 10.0 2.5 0.8 9.1 2.5 1.4 1 0 0 1 1 1 0 pKID domain Aldolase_II PF00596.19 MSTRG.11435.3_3 - 1.1e-38 132.9 0.1 1.8e-38 132.3 0.1 1.3 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain LRRFIP PF09738.7 MSTRG.9164.4_1 - 4.5e-16 59.1 1.4 4.5e-16 59.1 1.4 2.2 2 0 0 2 2 2 1 LRRFIP family APG6 PF04111.10 MSTRG.9164.4_1 - 0.0049 16.2 14.5 0.0069 15.7 14.5 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 IncA PF04156.12 MSTRG.9164.4_1 - 0.056 13.1 11.4 0.094 12.4 11.4 1.3 1 0 0 1 1 1 0 IncA protein Syntaxin-6_N PF09177.9 MSTRG.9164.4_1 - 0.069 13.6 3.6 0.16 12.4 3.6 1.6 1 0 0 1 1 1 0 Syntaxin 6, N-terminal ATG16 PF08614.9 MSTRG.9164.4_1 - 0.13 12.2 15.7 0.25 11.3 15.7 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) AAA_13 PF13166.4 MSTRG.9164.4_1 - 0.25 9.8 8.1 0.37 9.3 8.1 1.1 1 0 0 1 1 1 0 AAA domain TPR_MLP1_2 PF07926.10 MSTRG.9164.4_1 - 0.26 11.2 18.3 0.016 15.1 10.9 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein MAD PF05557.11 MSTRG.9164.4_1 - 0.78 7.9 16.7 1.1 7.4 16.7 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein TACC PF05010.12 MSTRG.9164.4_1 - 1.2 8.8 13.8 0.19 11.3 8.0 2.0 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC) BRE1 PF08647.9 MSTRG.9164.4_1 - 1.2 9.1 21.7 0.029 14.3 12.6 2.2 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase DUF3450 PF11932.6 MSTRG.9164.4_1 - 1.7 7.7 13.3 0.099 11.8 6.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF4164 PF13747.4 MSTRG.9164.4_1 - 2.9 8.1 14.1 0.59 10.3 9.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) Macoilin PF09726.7 MSTRG.9164.4_1 - 3.2 6.1 12.7 4.3 5.6 12.7 1.1 1 0 0 1 1 1 0 Transmembrane protein Exonuc_VII_L PF02601.13 MSTRG.9164.4_1 - 3.8 6.8 8.5 5.5 6.3 8.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit LRRFIP PF09738.7 MSTRG.9164.4_2 - 2e-65 221.1 26.8 2e-65 221.1 26.8 3.6 2 1 1 3 3 3 2 LRRFIP family GIT_CC PF16559.3 MSTRG.9164.4_2 - 6.9 6.7 7.4 7.5 6.5 0.3 2.8 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Phosphodiest PF01663.20 MSTRG.6727.1_3 - 4.6e-49 167.8 0.0 5.3e-49 167.6 0.0 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.16 MSTRG.6727.1_3 - 0.00022 20.5 0.0 0.0004 19.7 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.21 MSTRG.6727.1_3 - 0.00031 20.1 0.0 0.00031 20.1 0.0 1.2 1 0 0 1 1 1 1 Sulfatase PglZ PF08665.10 MSTRG.6727.1_3 - 0.0076 16.2 0.0 0.011 15.7 0.0 1.2 1 0 0 1 1 1 1 PglZ domain Hydrolase PF00702.24 MSTRG.13602.3_2 - 0.0045 17.2 0.0 0.0069 16.6 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.18 MSTRG.13602.3_3 - 3.5e-37 127.7 2.2 4.9e-37 127.2 2.2 1.2 1 0 0 1 1 1 1 E1-E2 ATPase P5-ATPase PF12409.6 MSTRG.13602.3_3 - 8.6e-30 103.3 0.0 2.1e-29 102.0 0.0 1.7 1 0 0 1 1 1 1 P5-type ATPase cation transporter Hydrolase PF00702.24 MSTRG.13602.3_3 - 1.8e-08 34.8 0.0 7.1e-08 32.9 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 MSTRG.13602.3_3 - 5.7e-08 32.2 0.0 1.2e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.4 MSTRG.13602.3_3 - 6.5e-08 32.4 0.0 1.4e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Forkhead PF00250.16 MSTRG.27395.1_2 - 2.1e-39 133.6 0.1 3.4e-39 132.9 0.1 1.3 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.24 MSTRG.27395.1_2 - 1.5e-09 37.9 0.0 2.9e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 FHA domain RRM_1 PF00076.20 MSTRG.17635.6_1 - 1.6e-30 104.6 0.0 2.4e-17 62.4 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 MSTRG.17635.6_1 - 0.00085 19.1 0.0 0.021 14.7 0.0 2.2 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.3 MSTRG.17635.6_1 - 0.002 18.1 0.0 0.01 15.8 0.0 2.1 3 0 0 3 3 3 1 RNA recognition motif RRM_3 PF08777.9 MSTRG.17635.6_1 - 0.003 17.5 0.0 0.79 9.7 0.0 2.2 2 0 0 2 2 2 2 RNA binding motif RRM_occluded PF16842.3 MSTRG.17635.6_1 - 0.04 13.6 0.0 0.07 12.9 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif DUF2457 PF10446.7 MSTRG.17635.6_1 - 1.5 7.8 9.7 1.8 7.5 9.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) FERM_C PF09380.8 MSTRG.9098.3_2 - 2.1e-24 85.6 0.0 4.9e-24 84.4 0.0 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FA PF08736.9 MSTRG.9098.3_2 - 3.1e-18 65.5 4.7 1.3e-17 63.5 4.7 2.2 1 0 0 1 1 1 1 FERM adjacent (FA) FERM_N PF09379.8 MSTRG.9098.3_2 - 1.3e-16 60.1 0.0 3.4e-16 58.8 0.0 1.8 1 0 0 1 1 1 1 FERM N-terminal domain FERM_M PF00373.16 MSTRG.9098.3_2 - 8.4e-15 55.1 0.0 8.4e-15 55.1 0.0 2.8 2 1 0 2 2 2 1 FERM central domain Sortilin-Vps10 PF15902.3 MSTRG.27258.1_1 - 3.4e-28 98.5 0.7 4.1e-28 98.3 0.7 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR_6 PF15899.3 MSTRG.27258.1_1 - 0.0018 18.0 3.8 0.053 13.5 0.2 2.8 3 0 0 3 3 3 2 BNR-Asp box repeat BNR PF02012.18 MSTRG.27258.1_1 - 0.0067 16.1 3.7 0.41 10.7 0.4 2.9 2 0 0 2 2 2 2 BNR/Asp-box repeat DUF4901 PF16244.3 MSTRG.27258.1_1 - 0.086 12.0 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4901) Pkinase_Tyr PF07714.15 MSTRG.5158.1_1 - 3.8e-63 213.1 0.0 5.2e-63 212.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.5158.1_1 - 8.8e-58 195.6 0.0 1.2e-57 195.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain RBD PF02196.13 MSTRG.5158.1_1 - 2.8e-26 91.2 0.0 8e-26 89.8 0.0 1.8 1 0 0 1 1 1 1 Raf-like Ras-binding domain C1_1 PF00130.20 MSTRG.5158.1_1 - 3.4e-12 45.9 7.1 8.8e-12 44.6 7.1 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.4 MSTRG.5158.1_1 - 2.8e-08 33.3 0.0 4.2e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like zf-RING-like PF08746.9 MSTRG.5158.1_1 - 7e-05 22.9 2.7 0.00026 21.1 2.7 2.1 1 0 0 1 1 1 1 RING-like domain C1_2 PF03107.14 MSTRG.5158.1_1 - 0.0036 17.5 3.6 0.0091 16.2 3.6 1.7 1 0 0 1 1 1 1 C1 domain APH PF01636.21 MSTRG.5158.1_1 - 0.06 13.1 0.0 0.19 11.5 0.0 1.8 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.12 MSTRG.5158.1_1 - 0.16 11.2 0.1 0.25 10.5 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Myb_DNA-bind_4 PF13837.4 MSTRG.11699.3_3 - 2.1e-101 332.4 16.4 1.1e-20 73.7 0.3 6.2 6 0 0 6 6 6 6 Myb/SANT-like DNA-binding domain Myb_DNA-bind_3 PF12776.5 MSTRG.11699.3_3 - 2e-16 60.4 7.9 0.095 13.4 0.0 6.3 6 0 0 6 6 6 5 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.7 MSTRG.11699.3_3 - 3.8e-13 49.4 16.9 0.026 14.7 0.1 6.3 6 0 0 6 6 6 5 Alcohol dehydrogenase transcription factor Myb/SANT-like DUF573 PF04504.12 MSTRG.11699.3_3 - 3e-08 34.1 9.0 1.7 9.3 0.0 6.2 6 0 0 6 6 6 3 Protein of unknown function, DUF573 Myb_DNA-bind_6 PF13921.4 MSTRG.11699.3_3 - 5.2e-08 32.9 14.6 0.065 13.4 0.1 6.9 6 0 0 6 6 6 3 Myb-like DNA-binding domain Myb_DNA-binding PF00249.29 MSTRG.11699.3_3 - 0.015 15.3 12.9 32 4.6 0.0 7.2 7 1 0 7 7 7 0 Myb-like DNA-binding domain UPF0004 PF00919.18 MSTRG.11699.3_3 - 0.094 12.6 0.4 22 5.1 0.0 3.1 3 0 0 3 3 3 0 Uncharacterized protein family UPF0004 HTH_AsnC-type PF13404.4 MSTRG.11699.3_3 - 1.6 8.5 11.7 19 5.1 0.1 5.6 6 0 0 6 6 6 0 AsnC-type helix-turn-helix domain BNIP2 PF12496.6 MSTRG.19727.3_3 - 3.3e-30 105.2 0.0 6.3e-30 104.2 0.0 1.5 1 0 0 1 1 1 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CRAL_TRIO_2 PF13716.4 MSTRG.19727.3_3 - 3.4e-29 101.6 0.1 5e-29 101.0 0.1 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.18 MSTRG.19727.3_3 - 5.5e-08 32.5 0.1 9.3e-08 31.8 0.1 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain DUF3340 PF11818.6 MSTRG.527.2_3 - 0.02 15.0 0.1 0.032 14.3 0.1 1.3 1 0 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) RPE65 PF03055.13 MSTRG.1758.1_1 - 3.9e-83 279.8 0.0 4.4e-83 279.7 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein DUF3944 PF13099.4 MSTRG.1758.1_2 - 0.14 11.9 0.6 0.29 10.9 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3944) Nuc_recep-AF1 PF11825.6 MSTRG.6200.3_1 - 2.1e-21 76.0 22.3 3.1e-21 75.4 22.3 1.2 1 0 0 1 1 1 1 Nuclear/hormone receptor activator site AF-1 zf-Tim10_DDP PF02953.13 MSTRG.13509.1_2 - 1.6e-26 91.6 2.8 3e-26 90.7 2.8 1.5 1 0 0 1 1 1 1 Tim10/DDP family zinc finger zf-H2C2_2 PF13465.4 MSTRG.11119.2_2 - 5.8e-41 137.0 34.1 1.3e-07 31.6 0.4 6.4 6 0 0 6 6 6 6 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.11119.2_2 - 6.6e-23 79.7 46.9 1.2e-05 25.3 0.7 7.8 8 0 0 8 8 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.11119.2_2 - 8.9e-21 72.7 39.6 0.0011 19.5 0.5 7.8 8 0 0 8 8 7 6 C2H2-type zinc finger zf-HYPF PF07503.10 MSTRG.11119.2_2 - 5.7e-07 29.1 19.9 0.29 10.8 0.1 5.6 6 0 0 6 6 5 3 HypF finger zf-LYAR PF08790.9 MSTRG.11119.2_2 - 2.9e-06 26.9 24.3 0.71 9.7 0.3 6.4 6 0 0 6 6 6 3 LYAR-type C2HC zinc finger zf-C2H2_6 PF13912.4 MSTRG.11119.2_2 - 5.4e-05 22.9 33.9 0.016 15.0 0.2 7.3 7 0 0 7 7 7 3 C2H2-type zinc finger zf-C2H2_11 PF16622.3 MSTRG.11119.2_2 - 5.6e-05 22.7 32.9 0.067 12.8 0.4 7.4 8 0 0 8 8 8 2 zinc-finger C2H2-type zf-met PF12874.5 MSTRG.11119.2_2 - 0.001 19.2 0.7 0.001 19.2 0.7 5.7 7 0 0 7 7 5 2 Zinc-finger of C2H2 type DUF3268 PF11672.6 MSTRG.11119.2_2 - 0.0012 19.1 9.3 0.048 13.9 0.5 3.3 1 1 1 3 3 3 1 zinc-finger-containing domain zf-C2HE PF16278.3 MSTRG.11119.2_2 - 0.0039 17.5 28.7 1.3 9.4 0.3 6.3 1 1 6 7 7 7 2 C2HE / C2H2 / C2HC zinc-binding finger Elf1 PF05129.11 MSTRG.11119.2_2 - 0.0048 16.8 2.2 0.0048 16.8 2.2 4.6 2 1 3 5 5 4 2 Transcription elongation factor Elf1 like BolA PF01722.16 MSTRG.11119.2_2 - 0.0054 16.9 2.4 11 6.3 0.1 3.7 1 1 2 3 3 3 0 BolA-like protein C1_1 PF00130.20 MSTRG.11119.2_2 - 0.0066 16.2 19.3 0.43 10.4 1.1 4.9 1 1 4 5 5 5 2 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-CHCC PF10276.7 MSTRG.11119.2_2 - 0.0096 15.8 18.5 0.42 10.6 0.4 5.9 6 0 0 6 6 6 1 Zinc-finger domain Zn-ribbon_8 PF09723.8 MSTRG.11119.2_2 - 0.017 15.1 20.4 1.2 9.2 2.5 5.0 1 1 3 4 4 4 0 Zinc ribbon domain zf-AN1 PF01428.14 MSTRG.11119.2_2 - 0.033 14.2 27.3 5.9 7.0 0.8 6.2 4 2 2 6 6 6 0 AN1-like Zinc finger HypA PF01155.17 MSTRG.11119.2_2 - 0.035 14.0 13.5 0.62 10.0 0.9 3.9 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.3 MSTRG.11119.2_2 - 0.042 14.5 13.4 2 9.1 3.4 3.7 1 1 3 4 4 4 0 zinc-ribbon family LIM PF00412.20 MSTRG.11119.2_2 - 0.075 13.1 22.2 0.59 10.3 1.6 5.3 1 1 3 5 5 5 0 LIM domain DNA_RNApol_7kD PF03604.11 MSTRG.11119.2_2 - 0.14 11.7 14.2 5 6.7 0.1 5.4 6 0 0 6 6 5 0 DNA directed RNA polymerase, 7 kDa subunit zf-Di19 PF05605.10 MSTRG.11119.2_2 - 0.24 11.6 19.4 2.7 8.2 0.8 4.3 2 2 3 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding YhfH PF14149.4 MSTRG.11119.2_2 - 0.47 10.3 14.7 16 5.4 0.1 4.6 4 1 1 5 5 4 0 YhfH-like protein zf-C2H2_2 PF12756.5 MSTRG.11119.2_2 - 0.62 10.3 18.1 4.6 7.5 0.2 5.3 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.6 MSTRG.11119.2_2 - 0.67 10.2 0.1 0.67 10.2 0.1 5.0 6 0 0 6 6 5 0 Zinc-finger double-stranded RNA-binding C1_4 PF07975.10 MSTRG.11119.2_2 - 0.91 9.7 18.6 1.4 9.1 1.4 4.2 1 1 5 6 6 6 0 TFIIH C1-like domain zf-trcl PF13451.4 MSTRG.11119.2_2 - 1.1 9.1 17.9 3.9 7.3 0.2 5.5 5 1 1 6 6 6 0 Probable zinc-ribbon domain zf-FCS PF06467.12 MSTRG.11119.2_2 - 1.5 8.7 19.6 7.2 6.5 0.3 5.3 3 2 2 5 5 5 0 MYM-type Zinc finger with FCS sequence motif zf-RRPl_C4 PF17026.3 MSTRG.11119.2_2 - 1.6 8.7 9.1 3.8 7.5 1.0 2.5 1 1 1 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type CpXC PF14353.4 MSTRG.11119.2_2 - 2.5 8.0 16.5 6.9 6.6 1.4 5.0 2 2 0 4 4 4 0 CpXC protein DUF983 PF06170.10 MSTRG.11119.2_2 - 3.2 8.1 13.9 40 4.6 0.1 5.7 6 0 0 6 6 6 0 Protein of unknown function (DUF983) ATPase-cat_bd PF12156.6 MSTRG.11119.2_2 - 3.3 8.4 18.4 1.5 9.5 3.9 3.6 1 1 2 4 4 4 0 Putative metal-binding domain of cation transport ATPase zf-ribbon_3 PF13248.4 MSTRG.11119.2_2 - 6.1 6.3 15.9 15 5.0 0.3 5.0 5 0 0 5 5 5 0 zinc-ribbon domain Desulfoferrod_N PF06397.10 MSTRG.11119.2_2 - 7.4 6.1 10.6 52 3.5 0.1 4.8 5 0 0 5 5 5 0 Desulfoferrodoxin, N-terminal domain UPF1_Zn_bind PF09416.8 MSTRG.11119.2_2 - 7.8 6.3 10.7 25 4.7 0.1 4.5 1 1 3 5 5 5 0 RNA helicase (UPF2 interacting domain) zf-ISL3 PF14690.4 MSTRG.11119.2_2 - 8.6 6.9 19.3 16 6.1 0.2 5.6 6 0 0 6 6 4 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Fer4_17 PF13534.4 MSTRG.11119.2_2 - 8.6 6.8 9.7 1.4e+02 3.0 0.8 4.7 2 1 2 4 4 4 0 4Fe-4S dicluster domain 14-3-3 PF00244.18 MSTRG.6120.1_1 - 1.5e-100 335.1 8.6 2e-100 334.7 8.6 1.1 1 0 0 1 1 1 1 14-3-3 protein Virulence_fact PF13769.4 MSTRG.6120.1_1 - 0.15 12.1 0.4 0.33 11.0 0.4 1.5 1 0 0 1 1 1 0 Virulence factor B12D PF06522.9 MSTRG.2495.2_3 - 1.5e-30 104.6 0.0 2.4e-30 104.0 0.0 1.3 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit MMR_HSR1 PF01926.21 MSTRG.13600.1_1 - 2.8e-13 49.8 0.1 2.2e-12 46.9 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.14 MSTRG.13600.1_1 - 2.8e-06 27.2 0.0 0.034 13.9 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 FeoB_N PF02421.16 MSTRG.13600.1_1 - 1.2e-05 24.8 0.0 0.0028 17.1 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B AIG1 PF04548.14 MSTRG.13600.1_1 - 0.0044 16.2 0.0 0.0071 15.6 0.0 1.3 1 0 0 1 1 1 1 AIG1 family Longin PF13774.4 MSTRG.21508.1_3 - 3e-25 87.9 0.1 6.7e-25 86.8 0.1 1.6 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.19 MSTRG.21508.1_3 - 1.3e-14 53.6 2.3 1.6e-14 53.3 0.1 2.0 2 0 0 2 2 2 1 Synaptobrevin Sec20 PF03908.11 MSTRG.21508.1_3 - 1 9.2 3.9 0.42 10.4 0.6 2.1 2 1 1 3 3 3 0 Sec20 Requiem_N PF14051.4 MSTRG.15838.3_1 - 1.1e-32 111.9 1.2 2e-32 111.0 1.2 1.5 1 0 0 1 1 1 1 N-terminal domain of DPF2/REQ. PHD PF00628.27 MSTRG.15838.3_1 - 7.9e-18 64.0 34.8 2.1e-11 43.4 7.6 4.4 3 1 1 4 4 4 2 PHD-finger Lar_restr_allev PF14354.4 MSTRG.15838.3_1 - 0.016 15.5 0.5 0.016 15.5 0.5 4.6 4 1 1 5 5 5 0 Restriction alleviation protein Lar zf-PHD-like PF15446.4 MSTRG.15838.3_1 - 0.83 9.1 15.4 0.16 11.4 2.1 3.5 2 1 0 3 3 3 0 PHD/FYVE-zinc-finger like domain PBP1_TM PF14812.4 MSTRG.15838.3_1 - 4.2 7.7 8.7 1.1 9.6 4.8 1.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Mtc1 PF10310.7 MSTRG.15838.3_1 - 8 5.2 6.5 11 4.7 6.5 1.1 1 0 0 1 1 1 0 Maintenance of telomere capping protein 1 Collagen PF01391.16 MSTRG.600.1_1 - 4.5e-126 410.5 539.0 5e-09 35.6 25.0 20.1 4 4 15 19 19 19 19 Collagen triple helix repeat (20 copies) C4 PF01413.17 MSTRG.600.1_1 - 1.6e-73 244.0 0.9 1e-37 128.7 0.0 2.3 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen Vert_HS_TF PF06546.9 MSTRG.25724.2_2 - 1.3e-30 106.8 6.7 2.9e-29 102.4 6.7 2.3 1 1 0 1 1 1 1 Vertebrate heat shock transcription factor HSF_DNA-bind PF00447.15 MSTRG.25724.2_2 - 7.7e-25 87.2 1.3 1.8e-24 86.0 1.3 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding ZapB PF06005.10 MSTRG.25724.2_2 - 0.2 12.0 4.9 0.064 13.6 1.9 1.7 2 0 0 2 2 2 0 Cell division protein ZapB CENP-H PF05837.10 MSTRG.25724.2_2 - 0.37 11.1 5.6 0.085 13.1 2.1 1.7 2 0 0 2 2 2 0 Centromere protein H (CENP-H) PDZ PF00595.22 MSTRG.13646.6_2 - 7.6e-64 211.9 8.9 7.2e-13 48.6 0.1 5.4 5 0 0 5 5 5 5 PDZ domain (Also known as DHR or GLGF) MAGI_u5 PF16666.3 MSTRG.13646.6_2 - 4e-31 107.8 12.3 4e-31 107.8 12.3 4.4 5 2 0 5 5 5 1 Unstructured region on MAGI PDZ_2 PF13180.4 MSTRG.13646.6_2 - 3.6e-28 97.6 0.5 0.00017 21.7 0.0 5.5 5 0 0 5 5 5 5 PDZ domain WW PF00397.24 MSTRG.13646.6_2 - 4.1e-07 29.7 0.8 9.8e-07 28.5 0.8 1.7 1 0 0 1 1 1 1 WW domain Tricorn_PDZ PF14685.4 MSTRG.13646.6_2 - 6.6e-07 29.1 7.2 1.2 9.1 0.0 5.3 5 0 0 5 5 5 4 Tricorn protease PDZ domain LAP1C PF05609.10 MSTRG.13646.6_2 - 0.76 8.7 3.3 3.5 6.5 3.6 1.9 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) MAT1 PF06391.11 MSTRG.7516.1_3 - 1.6e-26 93.3 15.9 1.8e-26 93.1 15.9 1.0 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 Xol-1_N PF09108.8 MSTRG.7516.1_3 - 0.051 13.3 0.2 0.064 13.0 0.2 1.2 1 0 0 1 1 1 0 Switch protein XOL-1, N-terminal Exonuc_VII_L PF02601.13 MSTRG.7516.1_3 - 2.2 7.6 9.6 2.7 7.3 9.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit HTH_23 PF13384.4 MSTRG.6710.1_2 - 0.0062 16.2 0.3 0.18 11.5 0.0 2.3 2 0 0 2 2 2 2 Homeodomain-like domain MARVEL PF01284.21 MSTRG.10383.1_1 - 1.9e-11 44.1 8.8 3.1e-11 43.4 8.8 1.4 1 0 0 1 1 1 1 Membrane-associating domain Occludin_ELL PF07303.11 MSTRG.10383.1_3 - 1.6e-23 83.2 8.1 2.6e-23 82.5 8.1 1.3 1 0 0 1 1 1 1 Occludin homology domain 7tm_2 PF00002.22 MSTRG.3237.1_1 - 8e-74 247.9 22.8 1.1e-73 247.4 22.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 MSTRG.3237.1_1 - 7.6e-17 61.2 7.7 2e-16 59.9 7.7 1.8 1 0 0 1 1 1 1 Hormone receptor domain Sigma_reg_N PF13800.4 MSTRG.3237.1_1 - 1.2 9.3 4.9 12 6.1 0.0 2.6 2 0 0 2 2 2 0 Sigma factor regulator N-terminal IL8 PF00048.18 MSTRG.24474.1_2 - 7.1e-17 61.2 0.5 1.3e-16 60.3 0.5 1.5 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Ribosomal_L15e PF00827.15 MSTRG.24474.1_2 - 0.078 12.6 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal L15 zf-CXXC PF02008.18 MSTRG.15942.2_2 - 1.8e-06 27.7 26.6 1.8e-06 27.7 26.6 2.8 2 0 0 2 2 2 2 CXXC zinc finger domain BicD PF09730.7 MSTRG.4389.2_3 - 8.5e-29 100.4 7.5 1.1e-28 100.0 7.5 1.0 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D Cep57_CLD_2 PF14197.4 MSTRG.4389.2_3 - 0.098 12.6 1.9 0.17 11.9 1.9 1.3 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 Lebercilin PF15619.4 MSTRG.25064.2_1 - 0.8 9.2 50.2 1.9 8.0 7.3 3.9 1 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease NPV_P10 PF05531.10 MSTRG.25064.2_1 - 9.8 6.6 18.4 0.2 12.0 2.7 4.3 2 1 2 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF4407 PF14362.4 MSTRG.25064.2_1 - 9.9 5.3 31.6 0.14 11.4 7.8 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) PolC_DP2 PF03833.11 MSTRG.12283.1_3 - 0.57 7.8 1.4 0.78 7.4 1.4 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 HNF-1A_C PF04813.10 MSTRG.12283.1_3 - 0.97 10.1 4.9 0.62 10.7 0.9 2.6 1 1 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus HECT PF00632.23 MSTRG.13393.2_2 - 1.7e-71 241.1 0.0 1.6e-39 136.1 0.0 2.1 1 1 1 2 2 2 2 HECT-domain (ubiquitin-transferase) RRM_1 PF00076.20 MSTRG.8817.1_1 - 8.3e-20 70.3 0.0 1.2e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Apt1 PF10351.7 MSTRG.8817.1_1 - 0.2 10.3 14.6 0.27 9.9 14.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain ORC6 PF05460.11 MSTRG.8817.1_1 - 0.46 9.6 10.3 0.66 9.1 10.3 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) MIP-T3 PF10243.7 MSTRG.8817.1_1 - 0.52 8.8 13.2 0.67 8.5 13.2 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Ig_2 PF13895.4 MSTRG.19158.2_1 - 6.5e-31 106.4 0.7 1.5e-10 41.1 0.0 6.0 6 0 0 6 6 6 4 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.19158.2_1 - 1.9e-25 89.2 0.7 5.3e-11 42.9 0.0 6.1 6 0 0 6 6 6 4 Immunoglobulin domain ig PF00047.23 MSTRG.19158.2_1 - 4e-15 55.6 0.0 2e-08 34.2 0.0 4.8 5 0 0 5 5 5 2 Immunoglobulin domain I-set PF07679.14 MSTRG.19158.2_1 - 7.6e-15 54.6 0.0 2.5e-09 36.9 0.0 3.9 4 0 0 4 4 4 3 Immunoglobulin I-set domain V-set PF07686.15 MSTRG.19158.2_1 - 7e-07 29.2 1.0 0.0099 15.9 0.0 4.2 5 1 0 5 5 5 2 Immunoglobulin V-set domain DUF4692 PF15763.3 MSTRG.19158.2_1 - 0.02 15.3 0.0 0.039 14.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4692) SLED PF12140.6 MSTRG.17482.2_3 - 8.7e-32 109.8 0.1 1.6e-31 109.0 0.1 1.4 1 0 0 1 1 1 1 SLED domain MBT PF02820.16 MSTRG.17482.2_3 - 9.3e-26 89.9 0.0 2e-25 88.8 0.0 1.5 1 0 0 1 1 1 1 mbt repeat RBR PF17208.1 MSTRG.17482.2_3 - 1.1e-20 73.9 10.1 3.5e-20 72.4 10.1 1.9 1 0 0 1 1 1 1 RNA binding Region SAM_1 PF00536.28 MSTRG.17482.2_3 - 7.5e-15 55.0 0.1 1.5e-14 54.0 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 MSTRG.17482.2_3 - 0.00016 21.5 0.0 0.00036 20.5 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 MSTRG.17482.2_3 - 0.025 14.4 0.0 0.048 13.5 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain SNARE_assoc PF09335.9 MSTRG.4305.1_2 - 9.8e-09 35.6 0.0 3e-08 34.0 0.0 1.8 1 0 0 1 1 1 1 SNARE associated Golgi protein IL15 PF02372.13 MSTRG.20850.1_1 - 0.027 14.3 0.4 0.031 14.1 0.4 1.1 1 0 0 1 1 1 0 Interleukin 15 Bcl-2 PF00452.17 MSTRG.24311.2_2 - 0.022 15.2 0.1 2.2 8.8 0.0 2.5 2 0 0 2 2 2 0 Apoptosis regulator proteins, Bcl-2 family DUF3898 PF13037.4 MSTRG.24311.2_2 - 0.089 12.8 0.1 0.15 12.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3898) Asp PF00026.21 MSTRG.20044.2_3 - 6e-20 71.8 0.0 7.7e-20 71.4 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.4 MSTRG.20044.2_3 - 0.0007 19.2 0.0 0.00094 18.8 0.0 1.1 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Sulfatase PF00884.21 MSTRG.21329.1_3 - 4.1e-69 233.2 0.0 5.3e-69 232.8 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.20 MSTRG.21329.1_3 - 0.011 15.2 0.0 0.039 13.4 0.0 1.8 1 1 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4560 PF15118.4 MSTRG.709.5_2 - 1e-32 111.8 1.5 1.8e-32 111.1 1.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4560) DUF3819 PF12842.5 MSTRG.12252.1_1 - 0.068 13.0 0.3 0.091 12.6 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3819) LRR_4 PF12799.5 MSTRG.5195.6_1 - 7.7e-18 64.1 17.4 3.5e-06 27.1 5.6 4.3 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 MSTRG.5195.6_1 - 2.6e-13 49.7 3.5 9.6e-06 25.1 0.0 2.9 2 1 0 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.4 MSTRG.5195.6_1 - 2.3e-11 43.1 18.2 3.7e-05 23.3 4.3 4.1 2 1 1 3 3 3 3 Leucine rich repeat LRR_1 PF00560.31 MSTRG.5195.6_1 - 4.2e-05 23.3 16.5 1.3 9.6 0.2 6.6 6 1 0 6 6 6 3 Leucine Rich Repeat LRR_6 PF13516.4 MSTRG.5195.6_1 - 0.013 15.3 20.2 0.59 10.2 0.4 5.5 6 0 0 6 6 6 0 Leucine Rich repeat Ig_2 PF13895.4 MSTRG.8262.2_3 - 0.0011 19.1 0.3 0.97 9.7 0.2 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 MSTRG.8262.2_3 - 0.0037 17.3 0.0 0.0098 15.9 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 MSTRG.8262.2_3 - 0.057 13.5 0.1 0.27 11.3 0.0 2.1 3 0 0 3 3 3 0 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.8262.2_3 - 0.077 13.5 0.3 1.9 9.0 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.29606.1_3 - 0.065 13.7 0.1 0.1 13.1 0.1 1.3 1 0 0 1 1 1 0 Immunoglobulin domain Myosin_head PF00063.19 MSTRG.17333.3_3 - 4.7e-136 454.6 0.4 5.6e-136 454.3 0.4 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_16 PF13191.4 MSTRG.17333.3_3 - 0.0022 18.3 0.0 0.026 14.8 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.4 MSTRG.17333.3_3 - 0.03 14.4 0.0 0.075 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.25 MSTRG.17333.3_3 - 0.043 14.2 0.0 0.096 13.1 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Microtub_bd PF16796.3 MSTRG.17333.3_3 - 0.046 13.6 0.0 0.09 12.6 0.0 1.4 1 0 0 1 1 1 0 Microtubule binding Sigma54_activat PF00158.24 MSTRG.17333.3_3 - 0.047 13.3 0.0 0.078 12.5 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF2075 PF09848.7 MSTRG.17333.3_3 - 0.057 12.5 0.1 0.083 12.0 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ATP_bind_2 PF03668.13 MSTRG.17333.3_3 - 0.13 11.4 0.1 0.2 10.8 0.1 1.3 1 0 0 1 1 1 0 P-loop ATPase protein family I-set PF07679.14 MSTRG.12795.4_2 - 0 1090.0 60.2 8.7e-21 73.7 0.0 27.7 27 0 0 27 27 27 26 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.12795.4_2 - 9.2e-230 743.8 66.3 9.6e-14 51.6 0.0 26.8 26 0 0 26 26 26 23 Immunoglobulin domain ig PF00047.23 MSTRG.12795.4_2 - 3.2e-185 600.8 86.5 7.1e-11 42.0 0.2 24.8 26 0 0 26 26 25 22 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.12795.4_2 - 5.1e-163 529.7 58.5 7.4e-09 35.7 0.2 24.5 18 2 6 24 24 24 20 Immunoglobulin domain V-set PF07686.15 MSTRG.12795.4_2 - 1.5e-63 211.6 92.7 0.00059 19.8 0.0 35.8 24 15 1 26 26 25 17 Immunoglobulin V-set domain Ig_5 PF16681.3 MSTRG.12795.4_2 - 6.9e-38 128.8 56.6 0.01 16.1 0.1 19.7 20 0 0 20 20 20 12 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 MSTRG.12795.4_2 - 5.8e-25 87.0 42.1 0.13 12.2 0.0 21.7 23 0 0 23 23 23 5 Izumo-like Immunoglobulin domain RhoGEF PF00621.18 MSTRG.12795.4_2 - 2e-18 67.1 0.0 5.2e-18 65.8 0.0 1.7 1 0 0 1 1 1 1 RhoGEF domain Ig_4 PF16680.3 MSTRG.12795.4_2 - 3.2e-17 62.5 65.2 0.39 11.0 0.1 19.5 19 0 0 19 19 18 7 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.10 MSTRG.12795.4_2 - 9.4e-17 60.7 45.3 0.41 10.6 0.0 19.8 21 0 0 21 21 20 4 CD80-like C2-set immunoglobulin domain fn3 PF00041.19 MSTRG.12795.4_2 - 1.8e-14 53.7 0.3 1e-12 48.1 0.0 3.7 3 0 0 3 3 2 1 Fibronectin type III domain BiPBP_C PF06832.10 MSTRG.12795.4_2 - 1.3e-12 47.5 0.1 6.2 6.8 0.0 11.6 14 0 0 14 14 11 1 Penicillin-Binding Protein C-terminus Family PH PF00169.27 MSTRG.12795.4_2 - 3.9e-07 30.4 0.6 2.8e-06 27.7 0.2 2.8 2 0 0 2 2 2 1 PH domain PKD_3 PF16820.3 MSTRG.12795.4_2 - 2.9e-06 26.8 0.1 7.8 6.2 0.0 7.1 7 0 0 7 7 7 0 PKD-like domain Receptor_2B4 PF11465.6 MSTRG.12795.4_2 - 7.8e-06 25.9 3.2 9.5 6.3 0.0 8.9 10 0 0 10 10 9 0 Natural killer cell receptor 2B4 C1-set PF07654.13 MSTRG.12795.4_2 - 1.8e-05 25.0 51.9 0.014 15.7 0.2 15.7 17 0 0 17 17 16 2 Immunoglobulin C1-set domain IQ PF00612.25 MSTRG.12795.4_2 - 3.9e-05 22.9 0.5 9e-05 21.8 0.5 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif Adeno_E3_CR1 PF02440.13 MSTRG.12795.4_2 - 0.00017 21.2 27.5 2 8.1 0.1 10.6 11 0 0 11 11 10 1 Adenovirus E3 region protein CR1 DUF943 PF06092.10 MSTRG.12795.4_2 - 0.035 13.6 0.0 0.2 11.2 0.0 2.3 1 0 0 1 1 1 0 Enterobacterial putative membrane protein (DUF943) IQ_SEC7_PH PF16453.3 MSTRG.12795.4_2 - 0.077 12.8 0.1 0.19 11.6 0.1 1.6 1 0 0 1 1 1 0 PH domain ACAS_N PF16177.3 MSTRG.12795.4_2 - 2.4 8.0 6.0 7.3 6.5 0.0 4.5 7 0 0 7 7 3 0 Acetyl-coenzyme A synthetase N-terminus Cadherin-like PF12733.5 MSTRG.12795.4_2 - 6.2 7.3 9.2 80 3.7 0.0 6.2 6 0 0 6 6 5 0 Cadherin-like beta sandwich domain GDPD PF03009.15 MSTRG.17087.2_3 - 3.2e-29 102.3 0.0 7.3e-29 101.1 0.0 1.6 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.4 MSTRG.17087.2_3 - 1.2e-06 28.7 0.2 1.2e-06 28.7 0.2 2.0 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family TFIIS_C PF01096.16 MSTRG.19775.1_1 - 4.9e-12 45.4 5.3 4.9e-12 45.4 5.3 3.2 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) MqsA_antitoxin PF15731.3 MSTRG.19775.1_1 - 0.012 15.6 3.9 0.43 10.5 0.1 2.3 2 1 0 2 2 2 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA DUF3716 PF12511.6 MSTRG.19775.1_1 - 0.075 12.9 0.6 0.075 12.9 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3716) Zn_Tnp_IS1595 PF12760.5 MSTRG.19775.1_1 - 0.17 11.7 13.8 1.6 8.7 2.1 3.4 3 0 0 3 3 3 0 Transposase zinc-ribbon domain RNA_POL_M_15KD PF02150.14 MSTRG.19775.1_1 - 0.21 11.4 11.9 0.17 11.6 3.3 2.9 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit DZR PF12773.5 MSTRG.19775.1_1 - 0.6 10.0 12.6 0.073 13.0 2.9 2.8 2 1 1 3 3 3 0 Double zinc ribbon zf-CSL PF05207.11 MSTRG.19775.1_1 - 1.9 8.2 7.5 2.9 7.5 1.3 2.5 2 0 0 2 2 2 0 CSL zinc finger OCRL_clath_bd PF16726.3 MSTRG.7453.2_2 - 0.027 14.5 0.0 0.047 13.7 0.0 1.3 1 0 0 1 1 1 0 Inositol polyphosphate 5-phosphatase clathrin binding domain OCRL_clath_bd PF16726.3 MSTRG.7453.2_3 - 7e-27 93.5 1.0 9.8e-20 70.5 0.1 2.3 2 0 0 2 2 2 2 Inositol polyphosphate 5-phosphatase clathrin binding domain Exo_endo_phos PF03372.21 MSTRG.7453.2_3 - 0.0083 16.2 0.0 0.018 15.2 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family ThiW PF09512.8 MSTRG.7453.2_3 - 0.2 11.6 0.2 0.31 11.0 0.2 1.2 1 0 0 1 1 1 0 Thiamine-precursor transporter protein (ThiW) zf-DNA_Pol PF08996.8 MSTRG.365.3_1 - 1.8e-39 135.3 0.1 2.6e-39 134.8 0.1 1.2 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B PF00136.19 MSTRG.365.3_2 - 1.3e-133 446.0 1.4 1.7e-133 445.6 1.4 1.1 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.17 MSTRG.365.3_2 - 2.1e-52 178.2 0.0 4.2e-52 177.2 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.6 MSTRG.365.3_2 - 4.1e-19 68.3 9.5 1.3e-18 66.7 9.5 1.9 1 0 0 1 1 1 1 DNA polymerase alpha subunit p180 N terminal DUF1744 PF08490.10 MSTRG.365.3_2 - 0.00074 18.1 0.7 0.0012 17.4 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_2 PF03175.11 MSTRG.365.3_2 - 0.002 16.9 0.0 0.0044 15.8 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral Proteasome PF00227.24 MSTRG.17593.2_3 - 1.7e-54 184.1 0.0 2.3e-54 183.7 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.7 MSTRG.17593.2_3 - 8.1e-14 50.8 0.5 1.6e-13 49.9 0.1 1.7 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature TRP_N PF14558.4 MSTRG.17593.2_3 - 0.086 13.1 0.1 0.4 10.9 0.0 2.0 2 0 0 2 2 2 0 ML-like domain DUF1682 PF07946.12 MSTRG.17593.2_3 - 2.5 7.1 11.5 3.5 6.6 11.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DUF1899 PF08953.9 MSTRG.8697.3_2 - 4.3e-32 109.7 0.0 8.5e-32 108.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.3 MSTRG.8697.3_2 - 1.3e-21 76.0 0.0 2.8e-21 75.0 0.0 1.6 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.30 MSTRG.8697.3_2 - 2e-15 56.7 9.2 9.4e-06 26.2 0.6 4.8 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.8697.3_2 - 9.1e-09 35.4 0.8 0.0013 18.8 0.0 2.8 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.3 MSTRG.8697.3_2 - 0.031 13.1 0.0 0.05 12.4 0.0 1.2 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain DUF853 PF05872.10 MSTRG.8697.3_2 - 0.13 10.7 0.0 0.37 9.2 0.0 1.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF853) Lectin_C PF00059.19 MSTRG.4721.1_2 - 7.1e-14 52.3 3.6 1.3e-13 51.5 3.6 1.4 1 0 0 1 1 1 1 Lectin C-type domain CIAPIN1 PF05093.11 MSTRG.4721.1_2 - 0.044 14.2 0.0 0.092 13.1 0.0 1.5 1 0 0 1 1 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis RVT_1 PF00078.25 MSTRG.9882.1_2 - 5.7e-35 120.7 0.0 7.3e-35 120.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Npa1 PF11707.6 MSTRG.9882.1_2 - 0.072 12.3 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Ribosome 60S biogenesis N-terminal Bromodomain PF00439.23 MSTRG.27701.2_2 - 9.5e-43 144.0 1.2 8.5e-21 73.7 0.0 2.4 2 0 0 2 2 2 2 Bromodomain BET PF17035.3 MSTRG.27701.2_2 - 1.5e-28 98.6 0.2 3.2e-28 97.6 0.2 1.6 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation BRD4_CDT PF17105.3 MSTRG.27701.2_2 - 3.7e-24 83.9 11.9 3.7e-24 83.9 11.9 3.9 4 0 0 4 4 4 1 C-terminal domain of bromodomain protein 4 DUF4964 PF16334.3 MSTRG.22483.2_1 - 0.036 13.5 0.1 0.059 12.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4964) Ribosomal_S25 PF03297.13 MSTRG.22483.2_2 - 0.085 13.0 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 S25 ribosomal protein TRAM_LAG1_CLN8 PF03798.14 MSTRG.27252.1_1 - 3.8e-42 144.1 18.0 6e-42 143.5 18.0 1.3 1 0 0 1 1 1 1 TLC domain TMEM135_C_rich PF15982.3 MSTRG.27252.1_1 - 0.081 13.3 2.4 0.23 11.9 0.1 2.4 1 1 0 2 2 2 0 N-terminal cysteine-rich region of Transmembrane protein 135 An_peroxidase PF03098.13 MSTRG.25082.1_3 - 2.7e-88 296.7 0.0 3e-88 296.5 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase Pkinase PF00069.23 MSTRG.13576.2_3 - 1.8e-73 247.0 0.0 4.9e-73 245.6 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.13576.2_3 - 7.4e-34 117.1 0.0 1.2e-33 116.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.13576.2_3 - 1.6e-08 34.1 0.0 2.7e-08 33.4 0.0 1.4 1 1 0 1 1 1 1 Kinase-like APH PF01636.21 MSTRG.13576.2_3 - 0.13 12.0 0.1 2.8 7.7 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family VCBS PF13517.4 MSTRG.11263.5_2 - 8.2e-20 71.0 21.5 6.4e-05 23.3 0.5 6.4 4 1 3 7 7 7 7 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.21 MSTRG.11263.5_2 - 2.7e-14 52.8 11.2 0.012 15.6 0.2 6.2 6 0 0 6 6 6 4 FG-GAP repeat TcdB_toxin_midN PF12256.6 MSTRG.11263.5_2 - 0.03 13.6 1.0 8.4 5.6 0.0 3.1 3 1 1 4 4 4 0 Insecticide toxin TcdB middle/N-terminal region FXMRP1_C_core PF12235.6 MSTRG.1747.1_2 - 6.1e-38 130.4 11.4 1.1e-37 129.6 11.4 1.4 1 0 0 1 1 1 1 Fragile X-related 1 protein core C terminal KH_1 PF00013.27 MSTRG.1747.1_2 - 4.7e-19 67.9 1.0 3.6e-10 39.4 0.7 2.8 2 0 0 2 2 2 2 KH domain Agenet PF05641.10 MSTRG.1747.1_2 - 2.5e-15 56.5 1.5 1.9e-07 31.3 0.1 3.3 3 1 0 3 3 3 2 Agenet domain KH_2 PF07650.15 MSTRG.1747.1_2 - 0.00037 20.1 0.3 0.48 10.2 0.0 2.7 2 0 0 2 2 2 2 KH domain KH_4 PF13083.4 MSTRG.1747.1_2 - 0.004 16.9 0.4 1.1 9.0 0.3 3.1 2 1 0 2 2 2 1 KH domain KH_5 PF13184.4 MSTRG.1747.1_2 - 0.17 11.9 1.1 2.8 8.0 0.6 2.6 2 0 0 2 2 2 0 NusA-like KH domain 5_nucleotid_C PF02872.16 MSTRG.25246.1_3 - 2.2e-44 151.3 0.0 3.7e-44 150.6 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.26 MSTRG.25246.1_3 - 2.7e-10 41.0 0.2 4.6e-10 40.2 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase RRM_1 PF00076.20 MSTRG.7871.1_1 - 2.2e-29 101.0 0.2 2.3e-14 52.8 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOPS PF08075.9 MSTRG.7871.1_1 - 6.7e-26 90.0 2.3 1.8e-25 88.7 2.3 1.8 1 0 0 1 1 1 1 NOPS (NUC059) domain RRM_7 PF16367.3 MSTRG.7871.1_1 - 0.0012 18.8 0.0 0.0065 16.4 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif DUF3327 PF11806.6 MSTRG.7871.1_2 - 0.0042 17.7 0.0 0.0042 17.7 0.0 3.0 2 1 1 3 3 3 1 Domain of unknown function (DUF3327) Torsin PF06309.9 MSTRG.23545.1_3 - 2.9e-49 166.3 0.1 4.5e-49 165.6 0.1 1.3 1 0 0 1 1 1 1 Torsin AAA PF00004.27 MSTRG.23545.1_3 - 0.0039 17.5 0.0 0.0064 16.8 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 MSTRG.23545.1_3 - 0.0041 17.3 0.0 0.083 13.0 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 MSTRG.23545.1_3 - 0.093 13.0 0.0 0.18 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Pet191_N PF10203.7 MSTRG.22338.1_3 - 3.7e-19 68.6 5.8 5.3e-19 68.2 5.8 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 COX6B PF02297.15 MSTRG.22338.1_3 - 0.24 11.5 3.4 0.56 10.4 3.4 1.6 1 1 0 1 1 1 0 Cytochrome oxidase c subunit VIb zf-RVT PF13966.4 MSTRG.10731.1_3 - 0.0013 19.4 0.0 0.0018 18.9 0.0 1.4 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase LRR_8 PF13855.4 MSTRG.13881.1_2 - 3.1e-21 74.8 10.6 4.7e-14 51.8 4.1 2.4 1 1 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.5 MSTRG.13881.1_2 - 1.1e-08 35.1 14.3 0.0009 19.4 0.4 3.6 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 MSTRG.13881.1_2 - 4.8e-06 26.1 6.6 0.00039 19.8 0.8 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_5 PF13306.4 MSTRG.13881.1_2 - 2.4e-05 24.2 0.0 3.5e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) Ig_3 PF13927.4 MSTRG.13881.1_2 - 0.0057 17.1 0.0 0.011 16.2 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRRCT PF01463.22 MSTRG.13881.1_2 - 0.0067 16.8 0.4 0.022 15.2 0.1 2.1 2 0 0 2 2 2 1 Leucine rich repeat C-terminal domain I-set PF07679.14 MSTRG.13881.1_2 - 0.058 13.3 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain LRR_1 PF00560.31 MSTRG.13881.1_2 - 0.3 11.6 10.7 34 5.3 0.4 4.9 5 1 0 5 5 5 0 Leucine Rich Repeat Ras PF00071.20 MSTRG.9695.1_3 - 7.8e-53 178.3 0.1 1.2e-52 177.6 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.9695.1_3 - 9.9e-32 109.6 0.0 1.9e-31 108.7 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.9695.1_3 - 1e-10 41.2 0.0 2e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 MSTRG.9695.1_3 - 0.0082 15.9 0.0 1.7 8.4 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 MSTRG.9695.1_3 - 0.0095 15.9 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 MSTRG.9695.1_3 - 0.012 15.0 0.0 0.023 14.1 0.0 1.4 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain PTN13_u3 PF16599.3 MSTRG.19811.2_1 - 0.2 11.5 0.0 0.29 11.1 0.0 1.2 1 0 0 1 1 1 0 Unstructured linker region on PTN13 protein between PDZ Band_7 PF01145.23 MSTRG.22862.2_2 - 7.3e-19 68.3 0.0 7.3e-19 68.3 0.0 2.6 2 1 0 2 2 2 1 SPFH domain / Band 7 family Flot PF15975.3 MSTRG.22862.2_2 - 5.8e-08 32.8 8.1 5.8e-08 32.8 8.1 3.3 2 2 1 3 3 3 2 Flotillin YjbH PF06082.9 MSTRG.22862.2_2 - 0.37 9.4 9.6 0.51 9.0 9.6 1.1 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH zf-C3HC4 PF00097.23 MSTRG.27715.1_1 - 1.4e-08 34.3 13.4 1.4e-08 34.3 13.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 MSTRG.27715.1_1 - 1.8e-07 31.1 11.9 5.2e-07 29.6 11.9 1.9 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 MSTRG.27715.1_1 - 8e-07 28.7 13.0 8e-07 28.7 13.0 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 MSTRG.27715.1_1 - 4.3e-06 26.4 8.7 4.3e-06 26.4 8.7 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.27715.1_1 - 7.5e-05 22.8 19.3 0.00024 21.2 15.0 3.0 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.4 MSTRG.27715.1_1 - 0.00025 20.8 13.0 0.00025 20.8 13.0 2.2 2 0 0 2 2 2 1 RING-type zinc-finger Tcf25 PF04910.12 MSTRG.27715.1_1 - 0.00047 19.2 0.2 0.00074 18.6 0.2 1.2 1 0 0 1 1 1 1 Transcriptional repressor TCF25 zf-rbx1 PF12678.5 MSTRG.27715.1_1 - 0.044 13.9 12.3 0.048 13.8 9.6 2.5 2 0 0 2 2 2 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.4 MSTRG.27715.1_1 - 0.16 11.7 10.3 0.5 10.1 10.3 1.9 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.3 MSTRG.27715.1_1 - 1.3 9.1 12.2 0.26 11.3 6.5 2.7 2 0 0 2 2 2 0 zinc RING finger of MSL2 CH PF00307.29 MSTRG.15182.2_1 - 3.6e-18 65.6 0.0 5.2e-18 65.1 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 MSTRG.15182.2_1 - 0.00014 21.5 0.0 0.00023 20.8 0.0 1.3 1 0 0 1 1 1 1 CAMSAP CH domain Smoothelin PF12510.6 MSTRG.15182.2_2 - 2e-19 69.2 1.2 3.3e-19 68.5 1.2 1.3 1 0 0 1 1 1 1 Smoothelin cytoskeleton protein CH PF00307.29 MSTRG.15182.2_2 - 1.6e-17 63.5 0.0 2.5e-15 56.5 0.0 2.3 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.6 MSTRG.15182.2_2 - 0.00093 18.9 0.0 0.0042 16.7 0.0 2.0 2 0 0 2 2 2 1 CAMSAP CH domain DUF3720 PF12517.6 MSTRG.15182.2_2 - 0.21 12.4 3.2 0.35 11.7 3.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3720) BNIP2 PF12496.6 MSTRG.19727.4_3 - 4.4e-30 104.8 0.0 7.4e-30 104.0 0.0 1.4 1 0 0 1 1 1 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CRAL_TRIO_2 PF13716.4 MSTRG.19727.4_3 - 5.6e-26 91.2 0.2 4.7e-25 88.2 0.0 2.1 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.18 MSTRG.19727.4_3 - 2.6e-07 30.4 0.1 4.1e-07 29.7 0.1 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain zf-C2H2 PF00096.24 MSTRG.21950.1_2 - 4.9e-71 231.3 219.9 0.00056 20.1 2.7 28.4 27 1 1 28 28 28 25 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.21950.1_2 - 3.2e-57 186.0 211.2 0.0011 19.5 0.4 28.5 28 0 0 28 28 28 24 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.21950.1_2 - 4.5e-40 135.1 139.1 7.1e-05 22.9 1.2 24.3 23 1 1 24 24 24 16 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.4 MSTRG.21950.1_2 - 3.5e-21 74.5 203.5 2.6e-06 27.5 0.7 28.1 32 0 0 32 32 32 17 Zinc-finger double domain zf-C2H2_6 PF13912.4 MSTRG.21950.1_2 - 4.1e-17 61.6 210.8 7.3e-06 25.7 0.9 26.2 26 2 0 26 26 26 16 C2H2-type zinc finger zf-met PF12874.5 MSTRG.21950.1_2 - 5.7e-17 61.4 178.3 0.006 16.8 1.2 24.6 25 1 1 26 26 26 14 Zinc-finger of C2H2 type ADK_lid PF05191.12 MSTRG.21950.1_2 - 0.0083 16.0 0.0 0.0083 16.0 0.0 15.0 16 3 1 17 17 17 2 Adenylate kinase, active site lid BolA PF01722.16 MSTRG.21950.1_2 - 0.012 15.8 20.8 0.096 12.9 0.5 6.6 6 0 0 6 6 6 0 BolA-like protein zf-C2HE PF16278.3 MSTRG.21950.1_2 - 0.047 14.0 0.0 0.047 14.0 0.0 18.0 13 8 7 20 20 20 0 C2HE / C2H2 / C2HC zinc-binding finger LRR_4 PF12799.5 MSTRG.15345.1_1 - 3.5e-06 27.1 0.1 6.7e-06 26.2 0.1 1.5 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 MSTRG.15345.1_1 - 8.6e-05 22.1 0.4 0.00015 21.3 0.4 1.3 1 0 0 1 1 1 1 Leucine rich repeat LRR_6 PF13516.4 MSTRG.15345.1_1 - 0.00039 20.1 0.4 1.5 9.0 0.2 2.5 2 0 0 2 2 2 2 Leucine Rich repeat Guanylate_kin PF00625.19 MSTRG.15345.1_3 - 4.3e-30 104.6 0.0 7.2e-30 103.9 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase LRR_9 PF14580.4 MSTRG.15345.1_3 - 2.1e-13 50.0 3.8 1.1e-12 47.7 2.7 2.0 1 1 1 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.5 MSTRG.15345.1_3 - 3.1e-08 33.6 16.5 0.00012 22.2 3.4 4.0 3 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 MSTRG.15345.1_3 - 0.0099 15.5 16.3 0.056 13.1 3.0 3.1 1 1 3 4 4 4 4 Leucine rich repeat AAA_5 PF07728.12 MSTRG.15345.1_3 - 0.082 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.20 MSTRG.15345.1_3 - 0.14 12.4 0.0 0.51 10.6 0.0 1.9 2 0 0 2 2 2 0 RNA helicase LRR_6 PF13516.4 MSTRG.15345.1_3 - 0.55 10.3 14.0 0.81 9.8 0.1 4.4 4 1 1 5 5 5 0 Leucine Rich repeat Oxysterol_BP PF01237.16 MSTRG.22935.1_2 - 4.8e-60 203.2 0.8 9.8e-60 202.2 0.0 1.9 2 0 0 2 2 2 1 Oxysterol-binding protein PH_8 PF15409.4 MSTRG.22935.1_2 - 3e-13 49.7 0.4 5.9e-13 48.8 0.4 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 MSTRG.22935.1_2 - 3.5e-08 33.8 0.9 1.2e-07 32.1 0.9 1.9 1 0 0 1 1 1 1 PH domain Caps_assemb_Wzi PF14052.4 MSTRG.22935.1_2 - 0.023 13.4 0.5 0.036 12.8 0.5 1.2 1 0 0 1 1 1 0 Capsule assembly protein Wzi Shugoshin_N PF07558.9 MSTRG.22935.1_2 - 0.085 12.6 1.9 0.31 10.8 1.9 2.0 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region PH_11 PF15413.4 MSTRG.22935.1_2 - 0.92 9.8 8.7 2.3 8.6 3.1 3.1 2 1 0 2 2 2 0 Pleckstrin homology domain DUF5110 PF17137.2 MSTRG.29284.1_1 - 0.0073 16.4 0.0 0.017 15.2 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF5110) TNRC6-PABC_bdg PF16608.3 MSTRG.7956.3_1 - 2.8e-57 194.5 31.7 2.3e-54 185.0 28.4 4.3 3 1 1 4 4 4 2 TNRC6-PABC binding domain Ago_hook PF10427.7 MSTRG.7956.3_1 - 4.9e-05 23.8 33.5 4.9e-05 23.8 33.5 5.9 3 2 1 5 5 5 1 Argonaute hook RRM_1 PF00076.20 MSTRG.7956.3_1 - 0.024 14.3 0.0 0.043 13.5 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DNApol3-delta_C PF09115.8 MSTRG.7956.3_1 - 0.06 13.7 4.8 0.11 12.9 4.8 1.2 1 0 0 1 1 1 0 DNA polymerase III, delta subunit, C terminal RRM_occluded PF16842.3 MSTRG.7956.3_1 - 0.093 12.5 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif MFS_1 PF07690.14 MSTRG.7215.1_1 - 9.2e-13 47.7 15.3 1.5e-12 47.0 15.3 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.22 MSTRG.7215.1_1 - 5.5e-09 35.3 6.9 5.5e-09 35.3 6.9 1.4 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_2 PF13347.4 MSTRG.7215.1_1 - 0.0007 18.1 3.1 0.0007 18.1 3.1 1.5 1 1 0 1 1 1 1 MFS/sugar transport protein TRI12 PF06609.11 MSTRG.7215.1_1 - 0.0029 15.9 0.4 0.004 15.5 0.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF1275 PF06912.9 MSTRG.7215.1_1 - 0.0069 16.2 5.2 0.015 15.1 5.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) B56 PF01603.18 MSTRG.18341.3_3 - 1.1e-198 660.1 12.2 1.4e-198 659.9 12.2 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) PTCB-BRCT PF12738.5 MSTRG.15700.1_1 - 5.9e-48 160.5 2.0 1.3e-19 69.7 0.0 5.0 5 0 0 5 5 5 4 twin BRCT domain BRCT PF00533.24 MSTRG.15700.1_1 - 4.2e-40 135.9 0.0 9.8e-11 41.8 0.0 6.3 6 1 0 6 6 6 5 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.3 MSTRG.15700.1_1 - 3.6e-29 100.9 0.0 8.4e-05 22.8 0.0 6.0 5 0 0 5 5 5 5 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.3 MSTRG.15700.1_1 - 1.7e-23 82.2 0.0 5.1e-17 61.5 0.0 3.9 3 0 0 3 3 3 2 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.3 MSTRG.15700.1_1 - 6.5e-17 61.5 0.1 5.6e-06 26.4 0.0 5.4 5 0 0 5 5 5 4 DNA ligase 3 BRCT domain Abhydrolase_1 PF00561.18 MSTRG.9815.1_3 - 5.1e-19 68.8 0.0 2.9e-18 66.3 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 MSTRG.9815.1_3 - 3.7e-09 36.1 0.0 7.7e-09 35.0 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.12 MSTRG.9815.1_3 - 0.13 10.8 0.0 0.2 10.2 0.0 1.2 1 0 0 1 1 1 0 Ndr family GKAP PF03359.11 MSTRG.10782.1_3 - 8.4e-67 226.0 0.4 1e-66 225.8 0.4 1.0 1 0 0 1 1 1 1 Guanylate-kinase-associated protein (GKAP) protein HA2 PF04408.21 MSTRG.2310.1_1 - 3.8e-18 65.6 0.0 8.2e-18 64.5 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.14 MSTRG.2310.1_1 - 1.4e-12 47.6 0.0 3.7e-12 46.2 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.29 MSTRG.2310.1_1 - 5.1e-10 39.6 0.1 9.8e-10 38.7 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain YTH PF04146.13 MSTRG.2310.1_3 - 1.7e-40 137.3 0.0 3.6e-40 136.3 0.0 1.6 1 0 0 1 1 1 1 YT521-B-like domain BTB PF00651.29 MSTRG.7580.1_2 - 2.6e-26 91.9 0.6 4e-26 91.3 0.6 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 MSTRG.7580.1_2 - 4.9e-11 42.4 25.0 3.5e-07 30.2 1.4 5.5 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.7580.1_2 - 1.5e-08 34.4 43.0 0.0014 18.9 1.5 5.4 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.7580.1_2 - 5.8e-08 32.8 41.0 0.0055 17.3 3.6 5.3 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.7580.1_2 - 0.00038 20.5 13.6 0.0028 17.8 0.0 3.9 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.9 MSTRG.7580.1_2 - 0.046 13.5 6.0 1.7 8.5 1.2 3.2 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-met PF12874.5 MSTRG.7580.1_2 - 0.12 12.7 0.1 0.12 12.7 0.1 3.8 4 0 0 4 4 4 0 Zinc-finger of C2H2 type GAGA PF09237.9 MSTRG.7580.1_2 - 0.34 10.6 6.6 1.2 8.9 0.2 3.3 2 1 1 3 3 3 0 GAGA factor zf-C2H2_6 PF13912.4 MSTRG.7580.1_2 - 9.5 6.2 21.1 4.4 7.2 0.2 4.4 4 0 0 4 4 4 0 C2H2-type zinc finger ASXH PF13919.4 MSTRG.19884.2_1 - 4.8e-33 113.9 0.4 1.8e-32 112.0 0.1 2.2 2 0 0 2 2 2 1 Asx homology domain PHD_3 PF13922.4 MSTRG.19884.2_1 - 2e-22 79.2 6.8 9.1e-22 77.1 6.8 2.2 1 0 0 1 1 1 1 PHD domain of transcriptional enhancer, Asx HARE-HTH PF05066.11 MSTRG.19884.2_1 - 7.8e-20 70.9 0.0 1.5e-19 70.0 0.0 1.5 1 0 0 1 1 1 1 HB1, ASXL, restriction endonuclease HTH domain AbLIM_anchor PF16182.3 MSTRG.11935.1_3 - 2.2e-74 251.4 13.0 3.5e-74 250.7 13.0 1.3 1 0 0 1 1 1 1 Putative adherens-junction anchoring region of AbLIM LIM PF00412.20 MSTRG.11935.1_3 - 3.6e-40 135.8 51.1 4.8e-11 42.6 8.2 4.6 4 1 0 4 4 4 4 LIM domain DUF566 PF04484.10 MSTRG.11935.1_3 - 0.54 9.8 4.7 0.97 9.0 4.7 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF566) MRP_L53 PF10780.7 MSTRG.22463.1_1 - 0.11 12.6 0.0 0.25 11.4 0.0 1.6 2 0 0 2 2 2 0 39S ribosomal protein L53/MRP-L53 MFS_1 PF07690.14 MSTRG.18393.1_3 - 2.7e-13 49.5 31.0 2.5e-09 36.4 12.2 3.1 2 1 0 3 3 3 2 Major Facilitator Superfamily MFS_2 PF13347.4 MSTRG.18393.1_3 - 2.5e-05 22.9 1.8 2.5e-05 22.9 1.8 2.9 4 0 0 4 4 4 2 MFS/sugar transport protein PUCC PF03209.13 MSTRG.18393.1_3 - 0.00021 20.3 0.8 0.0006 18.8 0.8 1.7 1 0 0 1 1 1 1 PUCC protein NUSAP PF16006.3 MSTRG.8838.1_3 - 3.9e-76 256.5 23.1 3.9e-76 256.5 23.1 2.0 2 0 0 2 2 2 1 Nucleolar and spindle-associated protein Collagen PF01391.16 MSTRG.3039.1_3 - 1.3e-26 91.9 138.7 2.9e-09 36.4 28.3 4.3 2 2 2 4 4 4 4 Collagen triple helix repeat (20 copies) EMI PF07546.11 MSTRG.3039.1_3 - 2.3e-15 57.0 13.0 6.2e-15 55.6 13.0 1.8 1 0 0 1 1 1 1 EMI domain PAS PF00989.23 MSTRG.11794.1_2 - 2.2e-09 37.1 0.0 4.4e-09 36.2 0.0 1.4 1 1 0 1 1 1 1 PAS fold HLH PF00010.24 MSTRG.11794.1_2 - 1e-05 25.2 0.3 2.1e-05 24.2 0.3 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_3 PF08447.10 MSTRG.11794.1_2 - 0.00091 19.3 0.1 0.0018 18.4 0.1 1.5 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.8 MSTRG.11794.1_2 - 0.03 14.4 0.0 0.052 13.7 0.0 1.3 1 0 0 1 1 1 0 PAS fold PAS_9 PF13426.5 MSTRG.11794.1_2 - 0.061 13.5 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 PAS domain Proteasome PF00227.24 MSTRG.15380.1_3 - 1.9e-39 135.0 0.0 2.6e-39 134.5 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Metallophos PF00149.26 MSTRG.19431.2_2 - 1.1e-38 133.6 0.1 1.6e-38 133.2 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.3 MSTRG.19431.2_2 - 4e-16 59.0 0.3 9.3e-16 57.9 0.3 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain PHD PF00628.27 MSTRG.7191.2_3 - 3.4e-10 39.5 4.9 1.3e-09 37.6 4.9 2.2 1 0 0 1 1 1 1 PHD-finger WHIM1 PF15612.4 MSTRG.7191.2_3 - 7e-08 31.7 0.0 1.5e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 DDT PF02791.15 MSTRG.7191.2_3 - 0.0026 17.9 0.0 0.0052 16.9 0.0 1.5 1 0 0 1 1 1 1 DDT domain WSD PF15613.4 MSTRG.7191.2_3 - 0.03 14.7 0.0 0.03 14.7 0.0 5.1 5 0 0 5 5 5 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif Pkinase PF00069.23 MSTRG.25922.1_2 - 2.9e-43 148.0 0.0 4.3e-43 147.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.25922.1_2 - 5.4e-42 143.7 0.0 7.9e-42 143.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 MSTRG.25922.1_2 - 0.0007 18.9 0.1 0.0012 18.2 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 MSTRG.25922.1_2 - 0.011 15.0 0.0 0.025 13.8 0.0 1.5 2 0 0 2 2 2 0 Kinase-like MMADHC PF10229.7 MSTRG.10849.1_1 - 4.6e-97 324.8 0.1 5.8e-97 324.5 0.1 1.1 1 0 0 1 1 1 1 Methylmalonic aciduria and homocystinuria type D protein DUF1682 PF07946.12 MSTRG.2524.5_3 - 9.9e-96 320.6 2.0 1.3e-95 320.2 2.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) DUF106 PF01956.14 MSTRG.2524.5_3 - 0.16 11.6 5.8 0.15 11.6 4.0 1.9 1 1 0 1 1 1 0 Integral membrane protein DUF106 Apyrase PF06079.9 MSTRG.19080.1_2 - 1.3e-127 424.9 0.0 1.7e-127 424.5 0.0 1.1 1 0 0 1 1 1 1 Apyrase Ant_C PF05586.9 MSTRG.3006.1_1 - 3.6e-42 142.7 0.4 5.9e-42 142.0 0.4 1.3 1 0 0 1 1 1 1 Anthrax receptor C-terminus region Anth_Ig PF05587.11 MSTRG.3006.1_1 - 1.3e-37 128.3 1.0 2.1e-37 127.6 1.0 1.4 1 0 0 1 1 1 1 Anthrax receptor extracellular domain VWA PF00092.26 MSTRG.3006.1_1 - 8.8e-24 84.6 0.0 1.2e-23 84.2 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.4 MSTRG.3006.1_1 - 7.2e-09 36.2 0.0 1.4e-08 35.2 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.12 MSTRG.3006.1_1 - 0.0073 15.6 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein Na_K-ATPase PF00287.16 MSTRG.6260.1_1 - 9.6e-95 316.9 0.0 1.2e-94 316.6 0.0 1.1 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain HPD PF05044.10 MSTRG.16434.2_1 - 4.7e-66 221.4 0.0 7.6e-66 220.7 0.0 1.2 1 0 0 1 1 1 1 Homeo-prospero domain CC190 PF15768.3 MSTRG.16434.2_1 - 0.09 12.7 0.4 0.15 12.0 0.4 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 190 Adenylsucc_synt PF00709.19 MSTRG.7577.2_1 - 3.5e-181 602.6 0.1 4.1e-181 602.3 0.1 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase HMG_box_2 PF09011.8 MSTRG.4722.3_1 - 5.4e-45 151.7 8.4 4.6e-26 91.1 3.3 2.2 2 0 0 2 2 2 2 HMG-box domain HMG_box PF00505.17 MSTRG.4722.3_1 - 7.1e-41 138.3 5.3 1.1e-23 83.2 0.1 2.2 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_5 PF14887.4 MSTRG.4722.3_1 - 0.075 12.9 1.0 8.3 6.3 0.0 2.2 2 0 0 2 2 2 0 HMG (high mobility group) box 5 zf-C4 PF00105.16 MSTRG.9297.1_3 - 8.2e-28 96.5 15.4 8.2e-28 96.5 15.4 2.0 3 0 0 3 3 3 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 MSTRG.9297.1_3 - 3.5e-17 62.6 0.0 5.9e-17 61.8 0.0 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor FOLN PF09289.8 MSTRG.9297.1_3 - 0.052 13.6 1.3 0.052 13.6 1.3 2.1 2 0 0 2 2 2 0 Follistatin/Osteonectin-like EGF domain SNAP PF14938.4 MSTRG.24726.1_3 - 8.9e-110 366.4 18.1 1.1e-109 366.1 18.1 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.4 MSTRG.24726.1_3 - 3.8e-08 33.4 5.3 0.00033 20.7 1.4 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.24726.1_3 - 7.3e-05 22.4 1.2 0.051 13.5 0.0 3.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.24726.1_3 - 0.00073 19.3 8.8 1.3 9.2 0.5 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.24726.1_3 - 0.0087 15.7 9.1 2.2 8.1 0.9 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.24726.1_3 - 0.013 15.9 2.4 5.9 7.6 0.2 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2076 PF09849.7 MSTRG.24726.1_3 - 0.023 14.6 0.0 0.037 13.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) TPR_16 PF13432.4 MSTRG.24726.1_3 - 0.035 14.7 0.2 1.2 9.7 0.0 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.24726.1_3 - 0.04 14.6 1.5 25 5.9 0.0 4.4 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.24726.1_3 - 0.044 13.9 13.9 5.3 7.4 0.4 5.4 4 1 1 5 5 4 0 Tetratricopeptide repeat Spatacsin_C PF14649.4 MSTRG.24726.1_3 - 0.072 12.1 7.1 0.35 9.9 0.6 2.7 1 1 0 2 2 2 0 Spatacsin C-terminus TPR_10 PF13374.4 MSTRG.24726.1_3 - 0.39 10.5 2.0 24 4.9 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.24726.1_3 - 0.46 10.9 3.4 2 8.9 0.9 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.24726.1_3 - 0.71 9.5 4.9 40 3.9 0.1 3.6 3 0 0 3 3 3 0 TPR repeat ANAPC3 PF12895.5 MSTRG.24726.1_3 - 1.1 9.4 5.9 1 9.5 2.1 2.8 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Sel1 PF08238.10 MSTRG.24726.1_3 - 6.8 7.4 5.5 10 6.8 0.1 3.5 4 0 0 4 4 3 0 Sel1 repeat Atg14 PF10186.7 MSTRG.1295.1_2 - 2.2e-51 174.8 10.6 3e-51 174.3 10.6 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Exonuc_VII_L PF02601.13 MSTRG.1295.1_2 - 1.9 7.8 10.9 2.8 7.3 10.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2570 PF10828.6 MSTRG.1295.1_2 - 3 7.6 8.3 6.3 6.6 8.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) ALMT PF11744.6 MSTRG.1295.1_2 - 3.8 6.1 4.6 5.6 5.6 4.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Anoctamin PF04547.10 MSTRG.25053.1_2 - 1.1e-06 27.6 0.0 1.4e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel MH2 PF03166.12 MSTRG.6764.1_3 - 2.8e-55 187.3 0.0 3.4e-55 187.0 0.0 1.0 1 0 0 1 1 1 1 MH2 domain IRF-3 PF10401.7 MSTRG.6764.1_3 - 0.0094 15.6 0.0 0.013 15.2 0.0 1.1 1 0 0 1 1 1 1 Interferon-regulatory factor 3 MARVEL PF01284.21 MSTRG.18328.4_2 - 7e-12 45.5 18.1 2.6e-11 43.6 18.1 2.0 1 1 0 1 1 1 1 Membrane-associating domain I-set PF07679.14 MSTRG.28506.1_2 - 1.1e-17 63.7 0.0 1.3e-17 63.4 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.28506.1_2 - 7.3e-11 42.4 0.0 9.3e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.28506.1_2 - 1.5e-08 34.7 0.0 1.9e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 MSTRG.28506.1_2 - 3.2e-06 27.1 0.0 3.8e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 MSTRG.28506.1_2 - 3.1e-05 23.9 0.0 3.6e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain C2-set_2 PF08205.10 MSTRG.28506.1_2 - 0.001 18.9 0.1 0.0013 18.6 0.1 1.5 1 1 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Crystall PF00030.17 MSTRG.1192.3_3 - 3.6e-20 71.8 0.0 4.2e-10 39.5 0.0 2.6 2 0 0 2 2 2 2 Beta/Gamma crystallin Choline_transpo PF04515.10 MSTRG.25790.1_3 - 7e-62 209.4 12.8 9e-62 209.0 12.8 1.1 1 0 0 1 1 1 1 Plasma-membrane choline transporter Chisel PF15355.4 MSTRG.16290.1_2 - 1.5e-37 127.5 0.8 2.8e-37 126.7 0.8 1.4 1 0 0 1 1 1 1 Stretch-responsive small skeletal muscle X protein, Chisel DnaJ PF00226.29 MSTRG.1744.1_2 - 2.3e-05 24.3 0.0 4e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.11 MSTRG.1744.1_2 - 0.018 14.9 0.0 0.029 14.3 0.0 1.2 1 0 0 1 1 1 0 Pam16 SelK_SelG PF10961.6 MSTRG.10806.1_2 - 5.9 7.4 6.7 1.9 9.0 0.3 2.4 2 0 0 2 2 2 0 Selenoprotein SelK_SelG fn3 PF00041.19 MSTRG.10806.1_3 - 1.2e-12 47.8 0.1 1.9e-12 47.2 0.1 1.3 1 0 0 1 1 1 1 Fibronectin type III domain DUF4808 PF16066.3 MSTRG.10806.1_3 - 3.8e-07 30.6 0.0 1.8e-06 28.4 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4808) Pur_ac_phosph_N PF16656.3 MSTRG.10806.1_3 - 0.034 14.6 0.0 0.074 13.5 0.0 1.6 1 1 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain NUDIX PF00293.26 MSTRG.3105.2_2 - 2.6e-07 30.6 0.0 4e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Choline_kinase PF01633.18 MSTRG.22514.1_1 - 5e-33 114.4 0.0 8e-33 113.7 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.21 MSTRG.22514.1_1 - 1e-09 38.5 0.0 1.6e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.18 MSTRG.22514.1_1 - 0.014 14.6 0.0 0.022 13.9 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase DUF1679 PF07914.9 MSTRG.22514.1_1 - 0.051 12.3 0.0 0.071 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) zf-met PF12874.5 MSTRG.12630.1_3 - 2.8e-20 71.9 15.8 5.4e-08 32.8 2.1 3.6 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.12630.1_3 - 4.3e-20 71.4 11.5 7.9e-09 35.5 2.0 3.3 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 MSTRG.12630.1_3 - 1.2e-07 31.8 2.7 0.059 13.6 0.2 3.3 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-U1 PF06220.10 MSTRG.12630.1_3 - 4.9e-06 26.1 6.2 0.037 13.7 0.5 3.3 3 0 0 3 3 3 2 U1 zinc finger AKAP95 PF04988.10 MSTRG.12630.1_3 - 0.00023 21.3 3.9 0.71 9.9 0.3 3.2 3 0 0 3 3 3 2 A-kinase anchoring protein 95 (AKAP95) zf-DBF PF07535.10 MSTRG.12630.1_3 - 0.014 15.4 0.7 0.014 15.4 0.7 3.1 3 0 0 3 3 3 0 DBF zinc finger DUF4187 PF13821.4 MSTRG.12630.1_3 - 0.021 14.4 0.1 3.5 7.3 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4187) zf-C2H2 PF00096.24 MSTRG.12630.1_3 - 0.032 14.6 10.9 2.4 8.7 1.5 3.8 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-RRPl_C4 PF17026.3 MSTRG.12630.1_3 - 0.089 12.8 2.0 3.5 7.6 0.1 2.9 3 0 0 3 3 3 0 Putative ribonucleoprotein zinc-finger pf C4 type zf-C2H2_4 PF13894.4 MSTRG.12630.1_3 - 0.13 13.0 7.1 15 6.6 0.4 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_9 PF16293.3 MSTRG.12630.1_3 - 0.19 11.4 2.8 17 5.2 0.1 3.2 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) PEPCK PF00821.16 MSTRG.19575.1_2 - 6e-265 879.9 0.0 7e-265 879.7 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase ATP-synt_ab PF00006.23 MSTRG.9424.1_3 - 1e-108 361.8 0.0 1.5e-108 361.3 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.3 MSTRG.9424.1_3 - 1.5e-42 144.1 0.0 2.8e-42 143.3 0.0 1.5 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.21 MSTRG.9424.1_3 - 1.4e-14 54.2 2.5 3.3e-14 53.0 2.5 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Amidohydro_1 PF01979.18 MSTRG.16666.1_1 - 2.7e-45 155.0 0.0 3.4e-45 154.7 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.9 MSTRG.16666.1_1 - 3.1e-12 46.6 0.1 2.5e-07 30.4 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family C2-set_2 PF08205.10 MSTRG.20146.1_1 - 1.3e-07 31.5 0.4 2.2e-07 30.7 0.4 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 MSTRG.20146.1_1 - 0.035 14.4 0.0 0.089 13.1 0.0 1.7 1 1 0 1 1 1 0 Immunoglobulin C1-set domain Guanylate_kin PF00625.19 MSTRG.1027.1_2 - 1.7e-64 216.7 0.1 2.2e-64 216.4 0.1 1.1 1 0 0 1 1 1 1 Guanylate kinase SH3_1 PF00018.26 MSTRG.1027.1_2 - 8.5e-07 28.3 0.0 1.6e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.1027.1_2 - 1.1e-05 24.9 0.0 1.9e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 MSTRG.1027.1_2 - 0.018 14.8 0.1 0.034 13.9 0.1 1.5 1 0 0 1 1 1 0 Variant SH3 domain DUF2502 PF10697.7 MSTRG.1027.1_2 - 0.11 12.7 0.3 0.11 12.7 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2502) HOIP-UBA PF16678.3 MSTRG.15719.1_3 - 8.2e-54 181.6 0.2 1.4e-53 180.8 0.2 1.4 1 0 0 1 1 1 1 UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase zf-RanBP PF00641.16 MSTRG.15719.1_3 - 2e-05 23.7 9.1 0.00042 19.4 0.9 5.2 6 0 0 6 6 6 3 Zn-finger in Ran binding protein and others HLH PF00010.24 MSTRG.5064.5_1 - 1e-16 60.5 0.2 1.7e-16 59.8 0.2 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF2353 PF09789.7 MSTRG.5064.5_1 - 0.0014 18.0 1.8 0.0019 17.5 1.8 1.1 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) Rootletin PF15035.4 MSTRG.5064.5_1 - 0.011 15.6 2.6 0.018 15.0 2.6 1.2 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion FlxA PF14282.4 MSTRG.5064.5_1 - 0.048 13.5 3.4 0.09 12.6 3.4 1.4 1 0 0 1 1 1 0 FlxA-like protein IncA PF04156.12 MSTRG.5064.5_1 - 0.081 12.6 1.8 0.15 11.7 1.8 1.4 1 0 0 1 1 1 0 IncA protein ZapB PF06005.10 MSTRG.5064.5_1 - 1.5 9.1 9.2 12 6.3 9.2 2.2 1 1 0 1 1 1 0 Cell division protein ZapB DUF4186 PF13811.4 MSTRG.26793.1_3 - 1.1 9.2 4.9 1.9 8.4 4.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4186) Connexin PF00029.17 MSTRG.10778.3_1 - 1.9e-77 259.9 12.7 6.4e-77 258.2 12.7 1.8 1 1 0 1 1 1 1 Connexin COX2_TM PF02790.13 MSTRG.10778.3_1 - 0.029 14.4 0.5 10 6.2 0.3 2.6 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain DUF912 PF06024.10 MSTRG.10778.3_1 - 1.4 9.1 3.7 1.5 9.0 0.4 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) HAP1_N PF04849.11 MSTRG.10778.3_3 - 0.033 13.3 0.4 0.045 12.8 0.4 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region Gag_p30 PF02093.14 MSTRG.9881.1_1 - 0.019 14.4 0.1 0.023 14.1 0.1 1.1 1 0 0 1 1 1 0 Gag P30 core shell protein SH3_9 PF14604.4 MSTRG.27382.2_2 - 2.2e-09 36.9 0.0 4.6e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.27382.2_2 - 4.6e-09 35.6 0.0 8.2e-09 34.8 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.27382.2_2 - 3.7e-07 29.6 0.0 2.8e-06 26.8 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_3 PF08239.9 MSTRG.27382.2_2 - 0.0037 17.4 0.0 0.0065 16.6 0.0 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain FCH PF00611.21 MSTRG.27382.2_3 - 9.9e-16 57.7 1.3 9.9e-16 57.7 1.3 3.1 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain KxDL PF10241.7 MSTRG.27382.2_3 - 0.008 16.3 1.9 0.008 16.3 1.9 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein Allexi_40kDa PF05549.9 MSTRG.27382.2_3 - 0.5 9.7 5.2 0.93 8.8 5.2 1.3 1 0 0 1 1 1 0 Allexivirus 40kDa protein CarboxypepD_reg PF13620.4 MSTRG.22521.3_1 - 0.00067 19.8 0.0 0.0011 19.1 0.0 1.2 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain DUF1241 PF06840.9 MSTRG.4291.2_2 - 2.8e-58 195.7 1.1 4.2e-58 195.1 1.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Peptidase_M10 PF00413.22 MSTRG.26714.1_1 - 1.6e-68 229.4 0.0 1.7e-67 226.0 0.0 2.1 1 1 0 1 1 1 1 Matrixin fn2 PF00040.17 MSTRG.26714.1_1 - 1.3e-52 175.6 46.4 8.9e-20 70.6 4.6 4.1 5 0 0 5 5 5 3 Fibronectin type II domain PG_binding_1 PF01471.16 MSTRG.26714.1_1 - 2.1e-11 43.7 0.3 4.3e-11 42.7 0.3 1.6 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.22 MSTRG.26714.1_1 - 0.0027 17.2 0.0 0.25 10.8 0.0 2.3 2 0 0 2 2 2 1 Astacin (Peptidase family M12A) Reprolysin_4 PF13583.4 MSTRG.26714.1_1 - 0.015 14.9 0.0 0.024 14.1 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.4 MSTRG.26714.1_1 - 0.035 14.5 0.0 0.068 13.6 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.7 MSTRG.26714.1_1 - 0.041 12.7 0.3 0.073 11.9 0.3 1.3 1 0 0 1 1 1 0 Peptidase M66 DUF4953 PF16313.3 MSTRG.26714.1_1 - 0.044 12.9 0.1 0.071 12.2 0.1 1.2 1 0 0 1 1 1 0 Met-zincin HORMA PF02301.16 MSTRG.20244.2_3 - 2.7e-08 33.5 0.0 4.3e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 HORMA domain K1377 PF15352.4 MSTRG.17813.1_2 - 3e-22 78.7 13.3 1.5e-12 46.6 1.5 4.2 4 0 0 4 4 4 4 Susceptibility to monomelic amyotrophy Peptidase_M10 PF00413.22 MSTRG.6292.1_2 - 4.4e-38 130.5 0.2 6.5e-38 129.9 0.2 1.3 1 0 0 1 1 1 1 Matrixin ShK PF01549.22 MSTRG.6292.1_2 - 1.5e-07 31.7 6.4 2.9e-07 30.8 6.4 1.5 1 0 0 1 1 1 1 ShK domain-like Ig_2 PF13895.4 MSTRG.6292.1_2 - 1.5e-06 28.3 0.0 3.4e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.6292.1_2 - 8.6e-05 22.9 0.0 0.00017 22.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Astacin PF01400.22 MSTRG.6292.1_2 - 0.0008 18.9 0.7 0.3 10.5 0.2 3.0 3 0 0 3 3 3 1 Astacin (Peptidase family M12A) Peptidase_M54 PF07998.9 MSTRG.6292.1_2 - 0.0069 16.3 0.2 0.019 14.9 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M54 I-set PF07679.14 MSTRG.6292.1_2 - 0.016 15.1 0.0 0.033 14.1 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain DUF4953 PF16313.3 MSTRG.6292.1_2 - 0.019 14.0 0.7 0.032 13.3 0.7 1.2 1 0 0 1 1 1 0 Met-zincin Peptidase_M57 PF12388.6 MSTRG.6292.1_2 - 0.023 14.2 1.3 0.045 13.2 1.3 1.4 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Reprolysin_3 PF13582.4 MSTRG.6292.1_2 - 0.056 13.8 0.1 0.12 12.8 0.1 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like V-set PF07686.15 MSTRG.6292.1_2 - 0.085 12.9 0.2 14 5.7 0.0 2.4 1 1 1 2 2 2 0 Immunoglobulin V-set domain ig PF00047.23 MSTRG.6292.1_2 - 0.092 12.8 0.1 0.3 11.1 0.1 1.8 1 1 0 1 1 1 0 Immunoglobulin domain Reprolysin_4 PF13583.4 MSTRG.6292.1_2 - 0.11 11.9 0.1 0.21 11.1 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.4 MSTRG.6292.1_2 - 0.18 11.8 0.6 0.33 11.0 0.6 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 Nucleoporin_FG2 PF15967.3 MSTRG.7113.4_1 - 2.2e-115 386.4 22.9 1.6e-89 300.9 8.5 2.0 1 1 1 2 2 2 2 Nucleoporin FG repeated region Mnd1 PF03962.13 MSTRG.7113.4_1 - 0.0047 16.7 1.7 0.0066 16.2 1.7 1.1 1 0 0 1 1 1 1 Mnd1 family PBC PF03792.11 MSTRG.7113.4_1 - 0.19 11.4 1.5 0.27 10.9 1.5 1.1 1 0 0 1 1 1 0 PBC domain V-set PF07686.15 MSTRG.21241.1_3 - 7.6e-15 54.9 0.0 1.2e-14 54.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 MSTRG.21241.1_3 - 0.0004 20.8 0.0 0.00078 19.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 MSTRG.21241.1_3 - 0.0042 17.1 0.0 0.01 15.9 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain EphA2_TM PF14575.4 MSTRG.21241.1_3 - 0.005 17.5 0.1 0.094 13.4 0.0 2.5 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain I-set PF07679.14 MSTRG.21241.1_3 - 0.0054 16.6 0.1 0.026 14.4 0.1 1.9 1 1 0 1 1 1 1 Immunoglobulin I-set domain IncA PF04156.12 MSTRG.21241.1_3 - 0.0092 15.7 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 1 IncA protein Orthoreo_P10 PF07204.9 MSTRG.21241.1_3 - 0.01 15.6 0.2 0.03 14.1 0.2 1.7 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 Ig_2 PF13895.4 MSTRG.21241.1_3 - 0.012 15.8 0.1 0.064 13.5 0.1 2.1 1 1 0 1 1 1 0 Immunoglobulin domain V-set_CD47 PF08204.9 MSTRG.21241.1_3 - 0.029 14.2 0.0 0.057 13.3 0.0 1.4 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain Protocadherin PF08374.9 MSTRG.21241.1_3 - 0.031 14.1 0.1 0.05 13.4 0.1 1.2 1 0 0 1 1 1 0 Protocadherin ATP1G1_PLM_MAT8 PF02038.14 MSTRG.21241.1_3 - 1.2 8.4 5.3 7.4 5.9 1.3 2.8 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family DSHCT PF08148.10 MSTRG.7925.1_3 - 2.3e-48 163.8 0.2 4.7e-48 162.8 0.2 1.5 1 0 0 1 1 1 1 DSHCT (NUC185) domain rRNA_proc-arch PF13234.4 MSTRG.7925.1_3 - 1.6e-26 93.6 0.0 3.4e-26 92.6 0.0 1.5 1 0 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.27 MSTRG.7925.1_3 - 6.5e-17 61.7 0.0 1.4e-16 60.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.7925.1_3 - 2.6e-07 30.9 0.0 1.2e-06 28.8 0.0 2.2 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.7925.1_3 - 0.00014 21.7 0.0 0.00038 20.4 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF3516 PF12029.6 MSTRG.7925.1_3 - 0.037 13.0 0.8 0.063 12.2 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3516) DUF4667 PF15700.3 MSTRG.7925.1_3 - 0.043 13.8 3.1 0.84 9.5 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4667) ADAM_spacer1 PF05986.12 MSTRG.12445.1_1 - 4.2e-30 104.0 0.0 6.5e-30 103.4 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Pep_M12B_propep PF01562.17 MSTRG.12445.1_1 - 4.5e-24 85.1 0.0 8.7e-24 84.2 0.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin PF01421.17 MSTRG.12445.1_1 - 1.6e-20 73.7 0.0 2.7e-20 73.0 0.0 1.4 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease TSP_1 PF00090.17 MSTRG.12445.1_1 - 2.6e-18 65.8 49.7 2.8e-10 40.1 5.1 5.7 6 0 0 6 6 6 3 Thrombospondin type 1 domain Reprolysin_5 PF13688.4 MSTRG.12445.1_1 - 1.8e-14 54.2 0.4 3.9e-14 53.1 0.4 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 MSTRG.12445.1_1 - 1.6e-12 47.9 0.0 3.2e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 MSTRG.12445.1_1 - 6.2e-06 26.1 0.1 1.2e-05 25.1 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 MSTRG.12445.1_1 - 0.0015 18.1 0.1 0.0027 17.2 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like MOZ_SAS PF01853.16 MSTRG.4926.3_2 - 1.2e-80 269.3 0.2 1.8e-80 268.7 0.2 1.3 1 0 0 1 1 1 1 MOZ/SAS family PHD PF00628.27 MSTRG.4926.3_2 - 9.5e-18 63.7 29.6 8e-11 41.5 8.5 3.8 3 1 1 4 4 4 2 PHD-finger Linker_histone PF00538.17 MSTRG.4926.3_2 - 2.5e-07 30.8 0.0 0.00045 20.4 0.0 2.5 2 0 0 2 2 2 2 linker histone H1 and H5 family PHD_2 PF13831.4 MSTRG.4926.3_2 - 0.0052 16.1 2.0 0.0052 16.1 2.0 3.3 3 0 0 3 3 3 2 PHD-finger Acetyltransf_7 PF13508.5 MSTRG.4926.3_2 - 0.01 16.1 0.0 0.026 14.8 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Prok-RING_1 PF14446.4 MSTRG.4926.3_2 - 6.4 6.7 15.0 9.6 6.1 0.5 2.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 PHD_4 PF16866.3 MSTRG.4926.3_2 - 7.9 6.5 23.2 0.022 14.7 8.5 3.4 2 1 2 4 4 4 0 PHD-finger OTU PF02338.17 MSTRG.24533.2_2 - 1.3e-13 51.4 0.0 2.4e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.7 MSTRG.24533.2_2 - 0.12 11.7 1.0 9.5 5.4 0.1 2.2 1 1 1 2 2 2 0 Peptidase C65 Otubain GTP_EFTU PF00009.25 MSTRG.6448.1_3 - 3.1e-55 186.6 0.3 4.2e-55 186.2 0.3 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.15 MSTRG.6448.1_3 - 9.1e-26 90.2 0.0 1.8e-25 89.3 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.23 MSTRG.6448.1_3 - 7.1e-14 51.8 1.5 7.1e-14 51.8 1.5 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 MSTRG.6448.1_3 - 0.00033 20.6 0.1 0.00057 19.8 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 MSTRG.6448.1_3 - 0.045 13.5 0.1 0.1 12.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function, DUF258 cobW PF02492.17 MSTRG.6448.1_3 - 0.053 13.0 0.6 0.091 12.2 0.1 1.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Glypican PF01153.17 MSTRG.24418.2_3 - 4.1e-104 349.3 0.0 5.7e-104 348.8 0.0 1.1 1 0 0 1 1 1 1 Glypican Calpain_III PF01067.20 MSTRG.19289.1_3 - 4e-53 179.3 0.0 1.9e-52 177.2 0.0 2.1 2 0 0 2 2 2 1 Calpain large subunit, domain III Peptidase_C2 PF00648.19 MSTRG.19289.1_3 - 2e-52 177.9 0.0 3.6e-52 177.1 0.0 1.4 1 0 0 1 1 1 1 Calpain family cysteine protease EF-hand_8 PF13833.4 MSTRG.19289.1_3 - 8e-12 44.6 1.4 9e-10 38.0 0.0 3.2 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.19289.1_3 - 1.5e-07 30.6 0.2 0.73 9.8 0.1 4.7 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.30 MSTRG.19289.1_3 - 4e-07 29.0 1.7 0.99 9.0 0.0 4.8 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.4 MSTRG.19289.1_3 - 0.00012 22.4 0.4 3.1 8.2 0.0 4.2 4 1 0 4 4 4 1 EF-hand domain pair PTRF_SDPR PF15237.4 MSTRG.5243.1_1 - 8.5e-87 290.7 36.2 7.3e-69 232.0 24.0 2.2 1 1 1 2 2 2 2 PTRF/SDPR family Reo_sigmaC PF04582.10 MSTRG.5243.1_1 - 0.0073 15.6 1.6 0.0073 15.6 1.6 1.6 2 0 0 2 2 2 1 Reovirus sigma C capsid protein DUF1664 PF07889.10 MSTRG.5243.1_1 - 3.3 7.6 22.9 0.22 11.4 5.7 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.10 MSTRG.5243.1_1 - 6.4 6.7 8.1 4.2 7.3 1.6 2.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus RhoGAP PF00620.25 MSTRG.20111.1_1 - 5.8e-45 152.7 0.0 1.2e-44 151.7 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain NUMOD3 PF07460.9 MSTRG.679.1_1 - 0.0083 16.3 0.3 0.014 15.6 0.3 1.4 1 0 0 1 1 1 1 NUMOD3 motif (2 copies) Anoctamin PF04547.10 MSTRG.5843.1_3 - 1.2e-162 541.5 24.0 1.9e-162 540.9 24.0 1.3 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.3 MSTRG.5843.1_3 - 7e-72 241.7 0.3 1e-71 241.1 0.3 1.3 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin OLF PF02191.14 MSTRG.13579.2_1 - 7.7e-86 287.6 8.0 1.4e-85 286.7 8.0 1.4 1 0 0 1 1 1 1 Olfactomedin-like domain 7tm_2 PF00002.22 MSTRG.13579.2_1 - 5.4e-68 228.8 20.1 8.9e-68 228.1 20.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Latrophilin PF02354.14 MSTRG.13579.2_1 - 1.4e-65 221.6 8.2 2.4e-65 220.9 8.2 1.3 1 0 0 1 1 1 1 Latrophilin Cytoplasmic C-terminal region GAIN PF16489.3 MSTRG.13579.2_1 - 6e-54 182.5 1.7 9.1e-54 181.9 1.7 1.3 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Gal_Lectin PF02140.16 MSTRG.13579.2_1 - 1.9e-23 82.6 1.1 1.9e-23 82.6 1.1 2.1 2 0 0 2 2 2 1 Galactose binding lectin domain GPS PF01825.19 MSTRG.13579.2_1 - 3.9e-14 52.9 7.2 1e-13 51.5 7.2 1.8 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif HRM PF02793.20 MSTRG.13579.2_1 - 8.7e-10 38.6 1.0 2.5e-09 37.2 1.0 1.9 1 0 0 1 1 1 1 Hormone receptor domain DUF5074 PF16819.3 MSTRG.13579.2_1 - 0.25 11.3 10.6 0.22 11.5 2.1 4.0 2 1 2 4 4 4 0 Domain of unknown function (DUF5074) zf-C2HCIx2C PF10782.7 MSTRG.13579.2_1 - 1.2 9.0 4.5 2.6 7.9 4.5 1.5 1 0 0 1 1 1 0 Zinc-finger DUF2975 PF11188.6 MSTRG.13579.2_1 - 6.2 6.6 8.2 0.74 9.6 2.9 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF2975) RPE65 PF03055.13 MSTRG.21877.1_3 - 8.4e-104 347.9 0.7 9.6e-104 347.7 0.7 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Folate_carrier PF01770.16 MSTRG.6255.1_3 - 5.2e-151 502.9 18.6 6.6e-151 502.6 18.6 1.1 1 0 0 1 1 1 1 Reduced folate carrier MFS_1 PF07690.14 MSTRG.6255.1_3 - 9.6e-09 34.5 19.7 9.6e-09 34.5 19.7 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily FHA PF00498.24 MSTRG.6854.1_1 - 7.2e-16 58.2 0.0 1.2e-15 57.4 0.0 1.4 1 0 0 1 1 1 1 FHA domain Glyco_hydro_18 PF00704.26 MSTRG.25476.2_1 - 2.7e-26 92.9 0.1 3.8e-26 92.4 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 zf-CCHC PF00098.21 MSTRG.19260.1_3 - 0.0056 16.6 1.9 0.013 15.4 1.9 1.7 1 0 0 1 1 1 1 Zinc knuckle eIF3g PF12353.6 MSTRG.19260.1_3 - 0.35 11.1 4.2 0.15 12.3 0.8 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G TelA PF05816.9 MSTRG.21723.1_1 - 0.19 10.6 13.1 0.37 9.7 13.1 1.5 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) DUF3138 PF11336.6 MSTRG.21723.1_1 - 0.19 10.1 0.5 0.28 9.6 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) T3SSipB PF16535.3 MSTRG.21723.1_1 - 0.78 10.1 13.9 1.3 9.4 13.4 1.6 1 1 0 1 1 1 0 Type III cell invasion protein SipB BLOC1_2 PF10046.7 MSTRG.21723.1_1 - 2.8 8.2 14.4 1.1 9.4 10.7 2.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2968 PF11180.6 MSTRG.21723.1_1 - 2.8 7.5 19.2 0.51 9.9 11.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) DUF2407_C PF13373.4 MSTRG.21723.1_1 - 2.9 7.9 5.7 5.6 7.0 5.6 1.5 1 1 0 1 1 1 0 DUF2407 C-terminal domain HMMR_N PF15905.3 MSTRG.21723.1_1 - 3.8 6.8 23.2 6.3 6.0 23.2 1.3 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Zn_clus PF00172.16 MSTRG.21723.1_3 - 0.039 13.9 0.5 0.039 13.9 0.5 2.2 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Aminotran_3 PF00202.19 MSTRG.15122.4_1 - 3.4e-60 203.7 0.0 4e-60 203.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Ig_2 PF13895.4 MSTRG.24919.2_2 - 9.1e-06 25.8 0.0 2.3e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.24919.2_2 - 6.5e-05 23.3 0.0 0.00017 22.0 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain PSI PF01437.23 MSTRG.24919.2_2 - 0.00012 22.4 0.6 0.00012 22.4 0.6 2.4 2 0 0 2 2 2 1 Plexin repeat ig PF00047.23 MSTRG.24919.2_2 - 0.0002 21.3 0.0 0.00037 20.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 MSTRG.24919.2_2 - 0.0018 18.2 0.0 0.003 17.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Sema PF01403.17 MSTRG.24919.2_3 - 3.1e-136 454.4 0.0 3.9e-136 454.1 0.0 1.1 1 0 0 1 1 1 1 Sema domain PSI PF01437.23 MSTRG.24919.2_3 - 0.00022 21.6 1.2 0.00071 19.9 1.2 1.9 1 0 0 1 1 1 1 Plexin repeat FAM212 PF15342.4 MSTRG.24919.2_3 - 0.15 11.7 0.7 0.4 10.4 0.7 1.8 1 0 0 1 1 1 0 FAM212 family ELL PF10390.7 MSTRG.8972.1_3 - 8.5e-83 277.9 0.7 1.8e-82 276.9 0.0 1.9 2 1 0 2 2 2 1 RNA polymerase II elongation factor ELL Occludin_ELL PF07303.11 MSTRG.8972.1_3 - 1.1e-31 109.3 14.7 1.7e-31 108.8 13.6 1.9 2 0 0 2 2 2 1 Occludin homology domain APG6 PF04111.10 MSTRG.8972.1_3 - 1.2 8.3 9.9 0.17 11.1 5.6 1.7 1 1 0 1 1 1 0 Autophagy protein Apg6 zf-H2C2_2 PF13465.4 MSTRG.17550.1_1 - 1.3e-42 142.3 42.8 7.9e-10 38.6 1.0 7.3 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.17550.1_1 - 1.6e-28 97.4 53.5 8.8e-06 25.8 1.2 7.2 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.17550.1_1 - 9e-25 85.1 47.4 1.3e-05 25.4 0.3 7.2 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.17550.1_1 - 1e-11 44.7 17.0 0.012 15.8 0.0 6.2 7 0 0 7 7 6 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.17550.1_1 - 1.4e-10 41.1 39.4 0.0025 18.0 2.4 6.6 7 0 0 7 7 7 5 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 MSTRG.17550.1_1 - 1.2e-08 34.5 38.6 0.0065 16.3 0.6 7.4 7 1 0 7 7 7 4 C2H2-type zinc finger zf-Di19 PF05605.10 MSTRG.17550.1_1 - 4.5e-07 29.9 28.6 0.00081 19.5 5.3 4.5 1 1 6 7 7 7 5 Drought induced 19 protein (Di19), zinc-binding BolA PF01722.16 MSTRG.17550.1_1 - 1.2e-06 28.6 4.3 0.18 11.9 1.0 4.3 1 1 2 3 3 3 2 BolA-like protein zf-H2C2_5 PF13909.4 MSTRG.17550.1_1 - 4.7e-05 22.9 32.0 0.027 14.1 0.6 5.6 5 0 0 5 5 5 4 C2H2-type zinc-finger domain LIM PF00412.20 MSTRG.17550.1_1 - 0.00016 21.7 28.1 0.035 14.2 2.7 5.8 3 3 1 4 4 4 2 LIM domain Ta0938 PF11494.6 MSTRG.17550.1_1 - 0.00021 21.4 10.0 0.093 12.9 0.1 4.3 1 1 3 4 4 4 1 Ta0938 zf-C2H2_2 PF12756.5 MSTRG.17550.1_1 - 0.00043 20.4 26.0 3.3 8.0 11.0 6.0 1 1 4 5 5 5 2 C2H2 type zinc-finger (2 copies) Zf_RING PF16744.3 MSTRG.17550.1_1 - 0.0024 17.8 17.4 1.5 8.9 0.1 5.8 1 1 5 6 6 6 1 KIAA1045 RING finger zf-C2HE PF16278.3 MSTRG.17550.1_1 - 0.011 16.1 31.3 0.24 11.8 0.2 6.0 1 1 5 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger zinc_ribbon_15 PF17032.3 MSTRG.17550.1_1 - 0.014 16.0 20.4 0.6 10.8 1.6 4.3 1 1 2 4 4 4 0 zinc-ribbon family zinc_ribbon_2 PF13240.4 MSTRG.17550.1_1 - 0.029 14.0 0.3 0.029 14.0 0.3 4.8 7 0 0 7 7 6 0 zinc-ribbon domain DUF2180 PF09947.7 MSTRG.17550.1_1 - 0.046 13.6 0.8 0.046 13.6 0.8 3.9 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2180) GAGA PF09237.9 MSTRG.17550.1_1 - 0.083 12.6 8.5 3.6 7.3 0.1 4.2 1 1 3 4 4 4 0 GAGA factor Yippee-Mis18 PF03226.12 MSTRG.17550.1_1 - 0.14 12.3 19.7 3.5 7.7 9.3 3.3 2 1 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-CHY PF05495.10 MSTRG.17550.1_1 - 0.3 11.6 31.5 8.7 6.9 8.4 4.6 1 1 2 3 3 3 0 CHY zinc finger zf-BED PF02892.13 MSTRG.17550.1_1 - 0.97 9.4 37.8 0.98 9.4 2.3 6.7 1 1 5 6 6 6 0 BED zinc finger HTH_18 PF12833.5 MSTRG.17550.1_1 - 1 9.6 5.4 24 5.1 0.1 3.9 5 0 0 5 5 4 0 Helix-turn-helix domain zf-trcl PF13451.4 MSTRG.17550.1_1 - 2.2 8.1 19.6 18 5.2 0.1 6.7 7 0 0 7 7 7 0 Probable zinc-ribbon domain Baculo_IE-1 PF05290.9 MSTRG.17550.1_1 - 3.1 7.6 9.5 2.6 7.9 0.7 3.4 1 1 3 4 4 4 0 Baculovirus immediate-early protein (IE-0) ADK_lid PF05191.12 MSTRG.17550.1_1 - 3.5 7.6 13.5 1 9.3 0.3 4.1 4 1 0 4 4 3 0 Adenylate kinase, active site lid zf-C2H2_9 PF16293.3 MSTRG.17550.1_1 - 4.5 7.1 13.9 23 4.8 0.1 4.9 6 0 0 6 6 6 0 C2H2 type zinc-finger (1 copy) zf-LYAR PF08790.9 MSTRG.17550.1_1 - 8.6 6.2 32.7 3 7.7 0.5 6.5 7 0 0 7 7 7 0 LYAR-type C2HC zinc finger SNF2_N PF00176.21 MSTRG.1723.1_1 - 3e-59 200.4 0.0 4.8e-59 199.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.29 MSTRG.1723.1_1 - 5.4e-16 58.8 0.0 1.4e-15 57.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.1723.1_1 - 6.2e-09 36.0 0.0 1.3e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.27 MSTRG.1723.1_1 - 2.3e-07 30.6 0.0 5.9e-07 29.3 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase HDA2-3 PF11496.6 MSTRG.1723.1_1 - 3.9e-07 29.4 0.0 1.3e-06 27.6 0.0 1.9 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ERCC3_RAD25_C PF16203.3 MSTRG.1723.1_1 - 0.0029 16.7 0.0 0.0053 15.9 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_22 PF13401.4 MSTRG.1723.1_1 - 0.012 15.8 0.0 1.1 9.4 0.0 3.1 2 1 0 2 2 2 0 AAA domain Rad54_N PF08658.8 MSTRG.1723.1_1 - 0.034 14.2 0.2 0.52 10.3 0.1 2.2 2 0 0 2 2 2 0 Rad54 N terminal NICE-1 PF15845.3 MSTRG.4573.1_2 - 0.08 13.6 7.8 0.15 12.7 7.8 1.4 1 0 0 1 1 1 0 Cysteine-rich C-terminal 1 family Zona_pellucida PF00100.21 MSTRG.19044.1_2 - 3.7e-27 95.6 0.9 5.2e-27 95.1 0.9 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain UBA PF00627.29 MSTRG.21730.3_3 - 2.3e-27 94.3 3.2 7e-14 51.3 0.2 2.5 2 0 0 2 2 2 2 UBA/TS-N domain XPC-binding PF09280.9 MSTRG.21730.3_3 - 4.7e-24 83.8 18.3 8.4e-24 83.0 18.3 1.4 1 0 0 1 1 1 1 XPC-binding domain ubiquitin PF00240.21 MSTRG.21730.3_3 - 2.7e-21 75.0 2.4 4.6e-21 74.2 2.4 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 MSTRG.21730.3_3 - 1.7e-07 30.8 4.1 2.6e-07 30.3 4.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.4 MSTRG.21730.3_3 - 2.5e-05 24.2 0.1 4.4e-05 23.4 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.8 MSTRG.21730.3_3 - 0.0035 17.0 0.0 0.094 12.4 0.0 2.3 2 0 0 2 2 2 1 Fungal ubiquitin-associated domain DUF2407 PF10302.7 MSTRG.21730.3_3 - 0.005 17.3 0.0 0.0096 16.3 0.0 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain DUF1296 PF06972.9 MSTRG.21730.3_3 - 0.032 14.2 0.0 1.7 8.7 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1296) Ubiquitin_2 PF14560.4 MSTRG.21730.3_3 - 0.069 13.5 0.5 0.14 12.5 0.5 1.6 1 1 0 1 1 1 0 Ubiquitin-like domain DUF3808 PF10300.7 MSTRG.23921.2_2 - 3.7e-57 194.0 0.0 4.2e-57 193.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) VEFS-Box PF09733.7 MSTRG.23921.2_2 - 0.009 15.7 0.1 0.015 15.0 0.1 1.3 1 0 0 1 1 1 1 VEFS-Box of polycomb protein DUF3439 PF11921.6 MSTRG.23921.2_2 - 0.042 13.7 0.4 0.064 13.1 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Trypsin PF00089.24 MSTRG.26749.1_2 - 3.4e-68 229.6 0.2 5.4e-68 229.0 0.2 1.3 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 MSTRG.26749.1_2 - 9.7e-36 122.3 0.0 2.2e-19 69.7 0.1 2.4 2 0 0 2 2 2 2 CUB domain Ldl_recept_a PF00057.16 MSTRG.26749.1_2 - 9.1e-26 89.7 52.4 2.2e-11 43.6 9.6 3.7 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A SEA PF01390.18 MSTRG.26749.1_2 - 1.6e-08 34.6 0.0 2.7e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 SEA domain Trypsin_2 PF13365.4 MSTRG.26749.1_2 - 5.5e-07 30.4 0.1 1.6e-06 29.0 0.1 1.7 1 0 0 1 1 1 1 Trypsin-like peptidase domain CUB_2 PF02408.18 MSTRG.26749.1_2 - 0.0076 15.9 0.1 0.018 14.7 0.1 1.6 1 0 0 1 1 1 1 CUB-like domain DUF1986 PF09342.9 MSTRG.26749.1_2 - 0.16 12.3 0.0 0.33 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) fn3 PF00041.19 MSTRG.2111.1_1 - 7.8e-05 22.8 0.0 0.0085 16.3 0.0 2.3 2 0 0 2 2 2 2 Fibronectin type III domain 2TM PF13239.4 MSTRG.2738.8_2 - 0.86 9.8 5.8 1.5 9.0 2.9 2.5 2 0 0 2 2 2 0 2TM domain Guanylate_kin PF00625.19 MSTRG.2738.8_3 - 5.2e-62 208.6 0.3 7.2e-62 208.2 0.3 1.2 1 0 0 1 1 1 1 Guanylate kinase MMR_HSR1 PF01926.21 MSTRG.2738.8_3 - 0.032 14.2 0.0 0.078 12.9 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase V_ATPase_I PF01496.17 MSTRG.3042.2_2 - 5.2e-207 689.4 4.1 6.7e-207 689.0 4.1 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Spore_YabQ PF09578.8 MSTRG.3042.2_2 - 2.8 8.1 14.8 0.62 10.2 6.6 2.9 2 1 0 2 2 2 0 Spore cortex protein YabQ (Spore_YabQ) DPM3 PF08285.9 MSTRG.3042.2_2 - 2.8 8.1 6.9 3.8 7.6 0.8 3.2 2 1 1 3 3 3 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) zf-C2H2_jaz PF12171.6 MSTRG.13137.1_1 - 0.0014 18.8 16.5 0.0028 17.8 2.6 5.7 7 0 0 7 7 7 2 Zinc-finger double-stranded RNA-binding GLE1 PF07817.11 MSTRG.13137.1_1 - 0.02 14.0 0.2 0.071 12.2 0.1 1.8 2 0 0 2 2 2 0 GLE1-like protein AKAP95 PF04988.10 MSTRG.13137.1_1 - 0.11 12.6 21.4 0.43 10.7 13.1 3.0 2 1 1 3 3 3 0 A-kinase anchoring protein 95 (AKAP95) zf-C4 PF00105.16 MSTRG.24461.2_3 - 1.1e-28 99.3 16.8 1.1e-28 99.3 16.8 2.9 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 MSTRG.24461.2_3 - 1.7e-19 70.1 0.1 3.2e-19 69.2 0.1 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Herpes_pp38 PF04846.11 MSTRG.24461.2_3 - 0.13 12.0 1.9 0.36 10.7 0.4 2.2 2 0 0 2 2 2 0 Herpesvirus pp38 phosphoprotein SRF-TF PF00319.16 MSTRG.22407.3_1 - 1e-23 82.4 0.4 1.9e-23 81.6 0.4 1.5 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.6 MSTRG.22407.3_1 - 2.9e-16 59.1 0.1 8.3e-16 57.6 0.1 1.8 1 0 0 1 1 1 1 Holliday junction regulator protein family C-terminal repeat Tim44 PF04280.13 MSTRG.4070.4_2 - 8.3e-24 84.2 0.0 1.3e-23 83.6 0.0 1.3 1 0 0 1 1 1 1 Tim44-like domain GAS2 PF02187.15 MSTRG.7672.4_3 - 3.9e-31 106.8 0.3 8e-31 105.8 0.3 1.6 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain EF-hand_1 PF00036.30 MSTRG.7672.4_3 - 1.5e-13 49.1 1.4 1.8e-05 23.8 0.4 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 MSTRG.7672.4_3 - 3e-12 45.3 0.9 0.00012 21.6 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.4 MSTRG.7672.4_3 - 1.4e-10 41.3 2.0 2.2e-10 40.7 0.6 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.7672.4_3 - 4.3e-08 32.2 8.5 4.4e-06 25.8 0.7 2.8 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.4 MSTRG.7672.4_3 - 8.3e-08 31.8 0.8 1.2e-06 28.0 0.2 2.4 1 1 1 2 2 2 2 EF-hand domain pair Spectrin PF00435.19 MSTRG.7672.4_3 - 2e-06 28.1 13.6 1.9e-05 25.0 2.7 3.3 3 0 0 3 3 3 2 Spectrin repeat NEMO PF11577.6 MSTRG.7672.4_3 - 0.041 13.8 0.2 0.041 13.8 0.2 3.1 2 1 1 3 3 3 0 NF-kappa-B essential modulator NEMO EF-hand_4 PF12763.5 MSTRG.7672.4_3 - 0.088 12.6 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand OMP_b-brl_3 PF14905.4 MSTRG.7672.4_3 - 0.2 10.5 0.5 0.31 9.8 0.5 1.2 1 0 0 1 1 1 0 Outer membrane protein beta-barrel family FXMRP1_C_core PF12235.6 MSTRG.7672.4_3 - 4.6 7.8 9.9 7.9 7.0 4.0 3.1 3 0 0 3 3 3 0 Fragile X-related 1 protein core C terminal SYS1 PF09801.7 MSTRG.2801.1_3 - 6.3e-06 26.3 11.4 1.1e-05 25.5 11.4 1.4 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network Cullin_binding PF03556.13 MSTRG.16057.1_3 - 3.8e-36 124.0 1.8 4.3e-36 123.8 0.5 1.8 2 0 0 2 2 2 1 Cullin binding UBA_4 PF14555.4 MSTRG.16057.1_3 - 9.5e-10 38.0 0.0 2.3e-09 36.8 0.0 1.7 1 0 0 1 1 1 1 UBA-like domain Pkinase PF00069.23 MSTRG.17764.1_1 - 5.2e-71 239.0 0.0 8.3e-71 238.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.17764.1_1 - 9e-34 116.8 0.0 1.3e-33 116.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 MSTRG.17764.1_1 - 1.2e-27 95.4 19.2 3.4e-14 52.3 3.0 2.7 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) PH PF00169.27 MSTRG.17764.1_1 - 3.9e-08 33.6 0.0 4.5e-07 30.2 0.0 2.5 2 0 0 2 2 2 1 PH domain Kinase-like PF14531.4 MSTRG.17764.1_1 - 5.8e-07 29.0 0.0 1.6e-06 27.5 0.0 1.6 1 1 0 1 1 1 1 Kinase-like C1_2 PF03107.14 MSTRG.17764.1_1 - 1.3e-05 25.3 14.9 0.012 15.8 1.6 2.8 2 0 0 2 2 2 2 C1 domain Kdo PF06293.12 MSTRG.17764.1_1 - 5.5e-05 22.5 0.0 0.0001 21.6 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.14 MSTRG.17764.1_1 - 0.041 13.9 0.0 0.096 12.7 0.0 1.5 1 0 0 1 1 1 0 ABC1 family zf-RING_9 PF13901.4 MSTRG.17764.1_1 - 0.11 12.3 13.5 1.2 8.9 0.4 2.4 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon RIO1 PF01163.20 MSTRG.17764.1_1 - 0.16 11.5 0.2 0.32 10.4 0.2 1.5 1 0 0 1 1 1 0 RIO1 family PHD PF00628.27 MSTRG.17764.1_1 - 2.7 7.8 19.6 1.9 8.3 3.0 2.8 2 0 0 2 2 2 0 PHD-finger FYVE_2 PF02318.14 MSTRG.17764.1_1 - 9.3 6.4 11.9 17 5.5 6.2 2.5 2 0 0 2 2 2 0 FYVE-type zinc finger TROVE PF05731.9 MSTRG.15656.2_3 - 2.4e-72 244.0 10.4 2.4e-72 244.0 10.4 2.3 2 0 0 2 2 2 1 TROVE domain WD40 PF00400.30 MSTRG.15656.2_3 - 7.4e-32 108.8 54.9 5.5e-07 30.0 0.0 15.3 15 0 0 15 15 14 9 WD domain, G-beta repeat DUF4062 PF13271.4 MSTRG.15656.2_3 - 3.3e-16 59.3 0.0 1.8e-15 56.9 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4062) NACHT PF05729.10 MSTRG.15656.2_3 - 4e-11 43.0 0.4 1.1e-10 41.6 0.4 1.7 1 0 0 1 1 1 1 NACHT domain Nup160 PF11715.6 MSTRG.15656.2_3 - 3.5e-09 35.7 3.9 0.0008 18.0 0.0 4.6 3 2 1 4 4 4 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.5 MSTRG.15656.2_3 - 4.7e-08 33.1 1.7 0.073 13.2 0.1 7.2 5 3 3 8 8 8 1 Anaphase-promoting complex subunit 4 WD40 domain AAA_16 PF13191.4 MSTRG.15656.2_3 - 8.4e-06 26.1 0.3 0.00012 22.4 0.3 3.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.4 MSTRG.15656.2_3 - 2.1e-05 24.7 1.4 8.6e-05 22.7 0.0 2.8 3 0 0 3 3 2 1 AAA domain WD40_like PF17005.3 MSTRG.15656.2_3 - 0.00055 19.2 0.0 0.74 9.0 0.2 2.5 2 0 0 2 2 2 2 WD40-like domain DUF1676 PF07898.11 MSTRG.15656.2_3 - 0.011 15.6 2.2 0.15 11.9 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) AAA_30 PF13604.4 MSTRG.15656.2_3 - 0.015 14.9 0.4 0.031 13.9 0.4 1.4 1 0 0 1 1 1 0 AAA domain AAA PF00004.27 MSTRG.15656.2_3 - 0.059 13.7 0.0 0.75 10.1 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.11 MSTRG.15656.2_3 - 0.068 12.0 0.2 0.12 11.2 0.2 1.2 1 0 0 1 1 1 0 TIP49 C-terminus AAA_28 PF13521.4 MSTRG.15656.2_3 - 0.15 12.2 1.4 0.35 11.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain Ferlin_C PF16165.3 MSTRG.15656.2_3 - 2.3 8.0 5.3 1.9 8.3 2.6 2.3 2 0 0 2 2 2 0 Ferlin C-terminus ABC_transp_aux PF09822.7 MSTRG.13035.1_2 - 4.6e-09 36.0 0.1 7.3e-09 35.4 0.1 1.3 1 0 0 1 1 1 1 ABC-type uncharacterized transport system DDOST_48kD PF03345.12 MSTRG.13035.1_2 - 1e-05 24.5 0.0 0.00022 20.1 0.0 2.1 1 1 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta DUF4159 PF13709.4 MSTRG.13035.1_2 - 0.13 11.5 0.1 0.35 10.1 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4159) DUF2116 PF09889.7 MSTRG.3826.1_3 - 0.034 14.0 1.3 0.067 13.0 1.3 1.5 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) AMMECR1 PF01871.15 MSTRG.2743.2_3 - 1.7e-37 128.5 0.0 2.6e-37 127.9 0.0 1.2 1 0 0 1 1 1 1 AMMECR1 Myosin_head PF00063.19 MSTRG.15727.1_2 - 2.5e-290 964.4 5.8 2.5e-290 964.4 5.8 3.8 5 0 0 5 5 5 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 MSTRG.15727.1_2 - 6.1e-162 540.8 266.9 7.7e-162 540.4 266.9 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.17 MSTRG.15727.1_2 - 7.7e-16 57.5 1.8 1.8e-15 56.3 1.8 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Reo_sigmaC PF04582.10 MSTRG.15727.1_2 - 3.3e-05 23.3 68.5 0.015 14.6 2.0 9.0 1 1 10 11 11 11 6 Reovirus sigma C capsid protein Filament PF00038.19 MSTRG.15727.1_2 - 0.021 14.3 230.4 0.018 14.5 18.9 9.2 1 1 8 9 9 9 0 Intermediate filament protein IQ PF00612.25 MSTRG.15727.1_2 - 0.055 13.2 0.4 0.7 9.7 0.1 2.6 2 0 0 2 2 2 0 IQ calmodulin-binding motif AAA_22 PF13401.4 MSTRG.15727.1_2 - 0.12 12.5 0.0 0.12 12.5 0.0 6.3 4 2 2 7 7 7 0 AAA domain AAA_16 PF13191.4 MSTRG.15727.1_2 - 0.43 10.8 0.0 0.43 10.8 0.0 6.1 3 2 0 4 4 4 0 AAA ATPase domain Sec1 PF00995.21 MSTRG.1337.6_2 - 2.1e-126 423.3 0.1 2.4e-126 423.1 0.1 1.0 1 0 0 1 1 1 1 Sec1 family cwf21 PF08312.10 MSTRG.1337.6_2 - 0.11 12.5 0.2 1 9.4 0.0 2.5 3 0 0 3 3 3 0 cwf21 domain 7tm_1 PF00001.19 MSTRG.13568.1_2 - 1.1e-34 119.8 19.6 1.6e-34 119.3 19.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Syja_N PF02383.16 MSTRG.13431.2_2 - 1.2e-90 303.9 0.2 1.5e-90 303.5 0.2 1.1 1 0 0 1 1 1 1 SacI homology domain PDZ PF00595.22 MSTRG.29406.1_1 - 2.3e-07 30.9 0.0 2.8e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.29406.1_1 - 3e-06 27.3 0.0 4.3e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 PDZ domain zf-CCHC PF00098.21 MSTRG.10735.1_2 - 0.0021 17.9 0.7 0.0021 17.9 0.7 2.1 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_2 PF13696.4 MSTRG.10735.1_2 - 0.12 12.0 0.5 0.12 12.0 0.5 1.8 2 0 0 2 2 2 0 Zinc knuckle Piwi PF02171.15 MSTRG.16632.2_2 - 9.1e-82 274.5 0.0 1.2e-81 274.2 0.0 1.1 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.20 MSTRG.16632.2_3 - 7.3e-31 106.7 0.2 1.2e-30 106.0 0.2 1.3 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.8 MSTRG.16632.2_3 - 4.1e-06 26.2 0.0 7.8e-06 25.3 0.0 1.5 1 0 0 1 1 1 1 Argonaute linker 1 domain Imm_superinfect PF14373.4 MSTRG.16632.2_3 - 0.11 12.3 1.3 0.22 11.4 1.3 1.5 1 0 0 1 1 1 0 Superinfection immunity protein fn3 PF00041.19 MSTRG.17755.1_2 - 2.7e-10 40.3 0.1 4.1e-10 39.7 0.1 1.2 1 0 0 1 1 1 1 Fibronectin type III domain VWA PF00092.26 MSTRG.17755.1_2 - 6.1e-08 33.0 0.0 3e-05 24.2 0.0 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain Urease_beta PF00699.18 MSTRG.7840.2_1 - 0.00035 20.4 0.4 3.5 7.6 0.0 4.1 1 1 3 4 4 4 2 Urease beta subunit Tetrabrachion PF11401.6 MSTRG.7840.2_1 - 0.21 11.5 3.3 51 3.8 0.0 4.1 5 0 0 5 5 5 0 Tetrabrachion MafB19-deam PF14437.4 MSTRG.7840.2_1 - 0.43 10.2 6.0 11 5.6 0.6 3.6 2 1 0 3 3 3 0 MafB19-like deaminase EF-hand_like PF09279.9 MSTRG.24720.1_3 - 0.00045 20.5 0.0 0.0014 18.9 0.0 1.7 1 1 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like IQ PF00612.25 MSTRG.20816.1_2 - 0.00065 19.1 1.0 0.0017 17.8 1.0 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif DUF3069 PF11269.6 MSTRG.20816.1_2 - 0.14 12.2 1.1 0.26 11.4 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3069) CLASP_N PF12348.6 MSTRG.12344.2_2 - 2e-32 112.5 3.8 1.4e-07 31.2 0.1 5.6 5 0 0 5 5 5 5 CLASP N terminal HEAT PF02985.20 MSTRG.12344.2_2 - 1e-15 56.3 11.3 0.006 16.6 0.1 11.6 12 0 0 12 12 12 4 HEAT repeat HEAT_2 PF13646.4 MSTRG.12344.2_2 - 4.3e-13 49.3 2.9 0.79 10.0 0.0 8.0 6 1 1 7 7 7 2 HEAT repeats Cnd1 PF12717.5 MSTRG.12344.2_2 - 7.1e-07 29.2 8.8 15 5.4 0.0 8.1 6 2 2 9 9 9 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.4 MSTRG.12344.2_2 - 0.0006 20.1 4.0 1.3 9.4 0.0 6.5 7 0 0 7 7 7 1 HEAT-like repeat Cohesin_HEAT PF12765.5 MSTRG.12344.2_2 - 0.00092 19.2 3.0 18 5.6 0.0 5.2 5 0 0 5 5 5 0 HEAT repeat associated with sister chromatid cohesion TAN PF11640.6 MSTRG.12344.2_2 - 0.0016 18.5 3.9 0.43 10.6 0.1 4.8 5 0 0 5 5 5 1 Telomere-length maintenance and DNA damage repair Vac14_Fab1_bd PF12755.5 MSTRG.12344.2_2 - 0.0028 18.1 0.1 71 3.9 0.0 5.6 5 1 2 7 7 7 0 Vacuolar 14 Fab1-binding region RasGEF_N_2 PF14663.4 MSTRG.12344.2_2 - 0.012 15.8 0.1 5.9 7.1 0.0 4.5 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain ParcG PF10274.7 MSTRG.12344.2_2 - 0.27 11.2 1.7 3.6 7.5 0.0 3.6 4 0 0 4 4 4 0 Parkin co-regulated protein DUF3561 PF12084.6 MSTRG.21494.1_3 - 0.1 12.5 3.4 4.8 7.1 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3561) TRAM1 PF08390.9 MSTRG.19486.1_3 - 4.8 6.8 7.4 8.7 5.9 7.4 1.4 1 0 0 1 1 1 0 TRAM1-like protein DHHA1 PF02272.17 MSTRG.19290.2_1 - 0.0005 19.9 0.1 0.00088 19.1 0.1 1.4 1 0 0 1 1 1 1 DHHA1 domain tRNA_SAD PF07973.12 MSTRG.19290.2_1 - 0.043 13.8 0.1 0.073 13.0 0.1 1.4 1 0 0 1 1 1 0 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_2c PF01411.17 MSTRG.19290.2_3 - 6.8e-19 67.6 0.0 8.8e-19 67.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) DUF1997 PF09366.8 MSTRG.19290.2_3 - 0.13 12.3 0.0 0.2 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1997) Senescence PF06911.10 MSTRG.5187.1_1 - 4.4e-49 167.0 8.1 7e-49 166.3 8.1 1.3 1 0 0 1 1 1 1 Senescence-associated protein MIT PF04212.16 MSTRG.5187.1_1 - 2.6e-06 27.3 0.0 6.2e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Pox_MCEL PF03291.14 MSTRG.4970.1_1 - 0.012 14.7 0.0 0.015 14.2 0.0 1.1 1 0 0 1 1 1 0 mRNA capping enzyme Pox_MCEL PF03291.14 MSTRG.4970.1_2 - 1e-97 327.2 0.0 1.3e-97 326.8 0.0 1.1 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.4 MSTRG.4970.1_2 - 2.9e-12 47.0 0.0 5.7e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 MSTRG.4970.1_2 - 5e-08 32.7 0.0 9.5e-08 31.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 MSTRG.4970.1_2 - 5.4e-08 33.2 0.0 1.3e-07 32.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.4 MSTRG.4970.1_2 - 2.7e-06 27.3 0.0 5.5e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 MSTRG.4970.1_2 - 0.012 16.2 0.0 0.073 13.7 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain CRT-like PF08627.8 MSTRG.29215.1_2 - 0.47 9.2 0.9 0.51 9.1 0.9 1.1 1 0 0 1 1 1 0 CRT-like, chloroquine-resistance transporter-like Glycos_transf_2 PF00535.24 MSTRG.18787.2_2 - 2.2e-32 112.1 0.0 3.5e-32 111.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.20 MSTRG.18787.2_2 - 6.6e-22 78.0 0.2 1e-21 77.4 0.2 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.12 MSTRG.18787.2_2 - 8.4e-09 34.8 0.0 4.9e-08 32.4 0.1 2.0 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 MSTRG.18787.2_2 - 0.0025 17.2 0.0 0.2 11.0 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Na_Ca_ex PF01699.22 MSTRG.6215.2_3 - 2.7e-52 176.6 48.8 7.9e-27 94.0 20.6 2.7 3 0 0 3 3 3 2 Sodium/calcium exchanger protein Requiem_N PF14051.4 MSTRG.14575.1_2 - 0.011 15.8 0.0 0.02 14.9 0.0 1.3 1 0 0 1 1 1 0 N-terminal domain of DPF2/REQ. Ion_trans_2 PF07885.14 MSTRG.14575.1_3 - 4.1e-13 49.0 7.6 6.4e-13 48.4 7.6 1.3 1 0 0 1 1 1 1 Ion channel DUF1669 PF07894.10 MSTRG.6395.2_3 - 2.1e-110 368.5 0.0 3.2e-110 367.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1669) PLDc_2 PF13091.4 MSTRG.6395.2_3 - 1.8e-06 27.7 0.0 3.1e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 PLD-like domain RVT_1 PF00078.25 MSTRG.25216.3_3 - 2.1e-25 89.5 0.1 3.2e-25 88.8 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PRELI PF04707.12 MSTRG.6405.1_1 - 4.3e-41 140.2 0.1 6.9e-41 139.5 0.1 1.3 1 0 0 1 1 1 1 PRELI-like family CRAL_TRIO PF00650.18 MSTRG.6405.1_1 - 5.8e-37 126.7 0.0 9.3e-37 126.1 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.13 MSTRG.6405.1_1 - 0.013 15.5 0.1 0.03 14.4 0.1 1.6 1 0 0 1 1 1 0 CRAL/TRIO, N-terminal domain Med9 PF07544.11 MSTRG.881.1_2 - 0.13 12.3 5.9 1.6 8.7 0.1 2.6 1 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 NARG2_C PF10505.7 MSTRG.11052.2_1 - 2.2e-30 105.7 0.1 3.1e-30 105.2 0.1 1.1 1 0 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus NARG2_C PF10505.7 MSTRG.11052.2_2 - 1.8e-24 86.3 0.0 3.3e-24 85.5 0.0 1.4 1 0 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus Peptidase_M10 PF00413.22 MSTRG.610.1_3 - 3.7e-09 36.5 0.0 4.8e-09 36.1 0.0 1.1 1 0 0 1 1 1 1 Matrixin EGF PF00008.25 MSTRG.7784.2_2 - 2.3e-78 257.8 272.8 7e-09 35.7 7.7 20.1 18 1 1 19 19 19 14 EGF-like domain hEGF PF12661.5 MSTRG.7784.2_2 - 4.3e-56 185.7 221.3 1.4e-07 31.8 6.9 19.6 18 0 0 18 18 18 14 Human growth factor-like EGF MNNL PF07657.11 MSTRG.7784.2_2 - 2.5e-25 88.2 3.6 2.5e-25 88.2 3.6 6.4 9 1 0 10 10 10 1 N terminus of Notch ligand DSL PF01414.17 MSTRG.7784.2_2 - 7e-25 86.8 7.8 7e-25 86.8 7.8 14.1 10 3 4 14 14 14 1 Delta serrate ligand EGF_2 PF07974.11 MSTRG.7784.2_2 - 1.4e-18 66.8 331.7 0.001 19.3 9.8 20.6 21 0 0 21 21 21 14 EGF-like domain EGF_CA PF07645.13 MSTRG.7784.2_2 - 1.3e-05 25.1 6.8 1.3e-05 25.1 6.8 18.3 11 5 8 19 19 19 12 Calcium-binding EGF domain cEGF PF12662.5 MSTRG.7784.2_2 - 0.00095 18.9 2.9 0.00095 18.9 2.9 16.4 18 0 0 18 18 18 4 Complement Clr-like EGF-like Glt_symporter PF03616.12 MSTRG.7784.2_2 - 0.011 14.3 0.0 0.016 13.7 0.0 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter PYST-C1 PF09690.8 MSTRG.15217.2_2 - 2 8.1 5.1 2.7 7.7 0.5 2.3 2 0 0 2 2 2 0 Plasmodium yoelii subtelomeric region (PYST-C1) MOZ_SAS PF01853.16 MSTRG.16599.1_3 - 5.1e-82 273.7 0.2 8.5e-82 273.0 0.2 1.4 1 0 0 1 1 1 1 MOZ/SAS family PHD PF00628.27 MSTRG.16599.1_3 - 4.7e-17 61.5 26.8 4.3e-10 39.2 9.5 3.7 2 1 1 3 3 3 2 PHD-finger Linker_histone PF00538.17 MSTRG.16599.1_3 - 0.0013 18.9 0.0 1.3 9.3 0.1 2.7 2 0 0 2 2 2 2 linker histone H1 and H5 family Acetyltransf_7 PF13508.5 MSTRG.16599.1_3 - 0.0031 17.8 0.0 0.0066 16.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PHD_2 PF13831.4 MSTRG.16599.1_3 - 0.57 9.6 17.9 0.073 12.5 2.2 3.6 3 0 0 3 3 3 0 PHD-finger PHD_4 PF16866.3 MSTRG.16599.1_3 - 5.9 6.9 20.7 0.041 13.9 8.2 3.4 1 1 1 2 2 2 0 PHD-finger BCL_N PF04714.11 MSTRG.17090.1_1 - 4.5e-27 93.7 4.4 1e-26 92.6 4.4 1.6 1 0 0 1 1 1 1 BCL7, N-terminal conserver region SLY PF12485.6 MSTRG.17783.1_1 - 1.1e-35 123.6 16.2 1.2e-35 123.5 12.2 2.5 2 0 0 2 2 2 1 Lymphocyte signaling adaptor protein SAM_2 PF07647.15 MSTRG.17783.1_1 - 2.3e-10 40.3 0.1 5.3e-10 39.1 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 MSTRG.17783.1_1 - 1e-07 32.1 0.0 2.1e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_2 PF07653.15 MSTRG.17783.1_1 - 1.5e-05 24.5 0.0 2.5e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.17783.1_1 - 0.024 14.1 0.0 0.04 13.4 0.0 1.4 1 0 0 1 1 1 0 SH3 domain Sen15 PF09631.8 MSTRG.12126.1_3 - 1.7e-11 44.2 0.0 3e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 Sen15 protein DUF2418 PF10332.7 MSTRG.17529.1_3 - 0.14 12.6 0.1 0.22 11.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2418) PP2C PF00481.19 MSTRG.13667.1_3 - 1.1e-33 116.8 0.0 9.4e-33 113.8 0.0 2.1 1 1 1 2 2 2 1 Protein phosphatase 2C TPPII PF12580.6 MSTRG.11357.2_3 - 6e-78 260.6 0.1 1.7e-77 259.1 0.0 1.7 2 0 0 2 2 2 1 Tripeptidyl peptidase II Peptidase_S8 PF00082.20 MSTRG.11357.2_3 - 1.4e-22 80.2 0.1 2.2e-22 79.5 0.1 1.3 1 0 0 1 1 1 1 Subtilase family TPPII_N PF12583.6 MSTRG.11357.2_3 - 1 9.8 5.1 0.14 12.6 0.5 1.9 2 0 0 2 2 2 0 Tripeptidyl peptidase II N terminal LRR_8 PF13855.4 MSTRG.2555.2_2 - 2.6e-22 78.2 41.5 8.4e-09 34.9 5.9 3.4 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 MSTRG.2555.2_2 - 5.3e-09 36.1 21.4 0.0039 17.4 4.3 4.3 1 1 5 6 6 6 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 MSTRG.2555.2_2 - 0.045 13.1 6.3 0.047 13.1 3.9 2.0 1 1 1 2 2 2 0 Leucine-rich repeat LRR_1 PF00560.31 MSTRG.2555.2_2 - 0.13 12.7 18.1 11 6.9 0.9 6.4 6 2 0 6 6 6 0 Leucine Rich Repeat Nbas_N PF15492.4 MSTRG.8310.4_1 - 2.3e-95 319.0 0.2 4.3e-95 318.1 0.2 1.5 1 0 0 1 1 1 1 Neuroblastoma-amplified sequence, N terminal Sec39 PF08314.9 MSTRG.8310.4_1 - 1.9e-29 102.5 0.0 6.1e-27 94.3 0.0 2.4 1 1 0 1 1 1 1 Secretory pathway protein Sec39 ArAE_2_N PF10337.7 MSTRG.8310.4_1 - 0.69 8.7 1.8 0.61 8.9 0.1 1.6 2 0 0 2 2 2 0 Putative ER transporter, 6TM, N-terminal Pkinase_Tyr PF07714.15 MSTRG.8891.1_2 - 5.7e-11 42.0 0.0 8.5e-11 41.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.8891.1_2 - 0.00019 20.7 0.0 0.00033 20.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain OmpH PF03938.12 MSTRG.8891.1_2 - 1 9.2 3.9 1.5 8.7 3.9 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF3552 PF12072.6 MSTRG.8891.1_2 - 4 6.7 9.9 5.7 6.2 9.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Pkinase PF00069.23 MSTRG.8891.1_3 - 1.5e-26 93.3 0.0 2e-26 92.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.8891.1_3 - 3.9e-25 88.5 0.0 5.6e-25 88.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase SH3_9 PF14604.4 MSTRG.8891.1_3 - 3.8e-11 42.5 0.1 6.7e-11 41.7 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.8891.1_3 - 4.5e-11 42.0 0.0 8.8e-11 41.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.8891.1_3 - 6e-09 35.3 0.0 1.7e-08 33.9 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Jun PF03957.11 MSTRG.18980.1_1 - 6.8e-61 206.0 4.3 1.1e-60 205.3 4.3 1.2 1 0 0 1 1 1 1 Jun-like transcription factor bZIP_1 PF00170.19 MSTRG.18980.1_1 - 5.6e-17 61.5 13.4 9e-17 60.8 13.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.15 MSTRG.18980.1_1 - 1.7e-07 31.5 9.3 2.9e-07 30.8 9.3 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_2 PF07716.13 MSTRG.18980.1_1 - 4.2e-07 29.8 10.9 8.7e-07 28.8 10.9 1.5 1 0 0 1 1 1 1 Basic region leucine zipper ZapB PF06005.10 MSTRG.18980.1_1 - 0.054 13.8 2.0 0.16 12.3 0.8 2.0 2 0 0 2 2 2 0 Cell division protein ZapB Jnk-SapK_ap_N PF09744.7 MSTRG.18980.1_1 - 0.12 12.4 3.2 0.18 11.8 3.2 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Pkinase PF00069.23 MSTRG.13749.1_2 - 3.7e-55 187.0 0.0 4.6e-55 186.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.13749.1_2 - 4.4e-25 88.3 0.0 5.6e-25 88.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.13749.1_2 - 2.7e-11 43.2 0.0 4.8e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 MSTRG.13749.1_2 - 0.0026 17.0 0.0 0.0043 16.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 MSTRG.13749.1_2 - 0.01 15.3 0.0 1.6 8.2 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.21 MSTRG.13749.1_2 - 0.015 15.1 0.2 0.16 11.7 0.1 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.9 MSTRG.13749.1_2 - 0.02 13.9 0.0 0.035 13.0 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 RIO1 PF01163.20 MSTRG.13749.1_2 - 0.069 12.6 0.1 0.12 11.8 0.1 1.3 1 0 0 1 1 1 0 RIO1 family Homeobox PF00046.27 MSTRG.12603.2_1 - 3.6e-22 77.8 7.5 6.2e-22 77.0 7.5 1.4 1 0 0 1 1 1 1 Homeobox domain SelP_N PF04592.12 MSTRG.12603.2_1 - 1.1 8.5 9.8 2 7.7 9.8 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Bromodomain PF00439.23 MSTRG.22204.1_1 - 8.7e-24 83.3 0.2 1.7e-23 82.4 0.2 1.5 1 0 0 1 1 1 1 Bromodomain DDT PF02791.15 MSTRG.22204.1_1 - 0.012 15.8 0.6 0.028 14.6 0.6 1.6 1 0 0 1 1 1 0 DDT domain TUSC2 PF15000.4 MSTRG.22204.1_1 - 0.048 13.8 0.4 0.23 11.6 0.4 2.2 1 0 0 1 1 1 0 Tumour suppressor candidate 2 PX PF00787.22 MSTRG.6142.2_1 - 2.3e-18 66.1 0.3 5.9e-18 64.8 0.3 1.7 1 0 0 1 1 1 1 PX domain RA PF00788.21 MSTRG.6142.2_1 - 6.2e-09 36.3 0.0 1.4e-08 35.2 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SSrecog PF03531.12 MSTRG.6142.2_1 - 0.05 12.8 0.0 0.078 12.2 0.0 1.2 1 0 0 1 1 1 0 Structure-specific recognition protein (SSRP1) Ank_5 PF13857.4 MSTRG.22983.1_2 - 1.2e-07 31.7 0.0 2e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.22983.1_2 - 4.1e-06 26.6 0.0 9.9e-06 25.4 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeat Ank PF00023.28 MSTRG.22983.1_2 - 6.5e-05 23.1 0.0 0.00017 21.7 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.5 MSTRG.22983.1_2 - 7.1e-05 23.2 0.0 0.00013 22.3 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.22983.1_2 - 0.00015 22.1 0.0 0.0003 21.2 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) SOCS_box PF07525.14 MSTRG.22983.1_3 - 2.4e-08 34.0 4.0 2.4e-08 34.0 4.0 1.6 2 0 0 2 2 2 1 SOCS box Axin_b-cat_bind PF08833.8 MSTRG.9847.1_3 - 0.083 12.9 1.3 0.083 12.9 1.3 2.2 3 0 0 3 3 3 0 Axin beta-catenin binding domain tRNA-synt_2d PF01409.18 MSTRG.21762.3_1 - 1.1e-90 303.3 0.0 1.6e-90 302.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2 PF00152.18 MSTRG.21762.3_1 - 0.0008 18.4 0.4 0.0034 16.4 0.1 2.1 2 1 0 3 3 3 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.23 MSTRG.21762.3_1 - 0.018 14.9 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) I_LWEQ PF01608.15 MSTRG.2307.3_2 - 2.8e-70 235.3 197.5 3.3e-49 166.9 17.2 18.3 8 5 9 18 18 18 9 I/LWEQ domain VBS PF08913.8 MSTRG.2307.3_2 - 1.4e-57 193.4 9.5 2.3e-55 186.2 0.7 11.7 9 2 5 14 14 14 3 Vinculin Binding Site Talin_middle PF09141.8 MSTRG.2307.3_2 - 2.5e-55 186.8 5.7 2.5e-55 186.8 5.7 15.8 8 4 5 15 15 15 4 Talin, middle domain FERM_M PF00373.16 MSTRG.2307.3_2 - 8.9e-29 100.2 0.1 8.9e-29 100.2 0.1 3.0 3 0 0 3 3 3 1 FERM central domain FERM_N PF09379.8 MSTRG.2307.3_2 - 9.6e-27 92.6 1.2 2.9e-26 91.0 1.2 1.9 1 0 0 1 1 1 1 FERM N-terminal domain ACBP PF00887.17 MSTRG.2307.3_2 - 2.5e-05 24.3 0.1 0.00021 21.3 0.0 2.8 2 0 0 2 2 2 1 Acyl CoA binding protein IRS PF02174.15 MSTRG.2307.3_2 - 0.00016 21.3 0.0 0.0004 20.1 0.0 1.6 1 0 0 1 1 1 1 PTB domain (IRS-1 type) TMEM107 PF14995.4 MSTRG.12544.2_2 - 5e-09 36.5 3.8 5e-09 36.5 3.8 2.5 2 1 0 2 2 2 1 Transmembrane protein DUF420 PF04238.10 MSTRG.12544.2_2 - 0.054 13.6 3.0 0.59 10.3 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF420) Myf5 PF12232.6 MSTRG.5886.1_3 - 2.6e-20 72.8 6.4 5.4e-20 71.8 6.4 1.5 1 0 0 1 1 1 1 Myogenic determination factor 5 Basic PF01586.14 MSTRG.5886.1_3 - 5.2e-19 69.1 1.5 5.2e-19 69.1 1.5 2.0 2 0 0 2 2 2 1 Myogenic Basic domain HLH PF00010.24 MSTRG.5886.1_3 - 4e-15 55.4 1.9 7.7e-15 54.5 1.9 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF3915 PF13054.4 MSTRG.15855.1_1 - 1.2 9.0 5.5 2.2 8.1 5.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) FAM27 PF15832.3 MSTRG.15855.1_2 - 1.3 9.4 15.6 3.1 8.3 8.1 2.7 2 0 0 2 2 2 0 FAM27 D and E protein family DUF3915 PF13054.4 MSTRG.15855.1_2 - 6.7 6.6 9.8 0.26 11.1 3.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) Homeobox PF00046.27 MSTRG.15855.1_3 - 2.1e-22 78.6 9.2 3.7e-22 77.8 9.2 1.4 1 0 0 1 1 1 1 Homeobox domain OAR PF03826.15 MSTRG.15855.1_3 - 2.5e-08 33.3 1.1 4.1e-08 32.6 1.1 1.4 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.9 MSTRG.15855.1_3 - 0.0032 17.2 0.6 0.01 15.6 0.6 1.9 1 0 0 1 1 1 1 Homeobox KN domain Auxin_canalis PF05703.9 MSTRG.15855.1_3 - 2 8.2 7.1 3.4 7.4 7.1 1.2 1 0 0 1 1 1 0 Auxin canalisation RRM_1 PF00076.20 MSTRG.17510.3_2 - 1.3e-30 104.8 0.0 2.1e-14 52.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Es2 PF09751.7 MSTRG.17510.3_2 - 0.042 13.5 0.1 0.069 12.8 0.1 1.3 1 0 0 1 1 1 0 Nuclear protein Es2 RRM_7 PF16367.3 MSTRG.17510.3_2 - 0.12 12.4 0.0 9.4 6.3 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif ARS2 PF04959.11 MSTRG.1044.1_1 - 5e-78 261.8 0.1 1.2e-77 260.6 0.1 1.6 1 0 0 1 1 1 1 Arsenite-resistance protein 2 DUF3546 PF12066.6 MSTRG.1044.1_1 - 3e-37 127.1 2.6 3e-37 127.1 2.6 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3546) DUF1777 PF08648.10 MSTRG.1044.1_1 - 0.06 13.5 31.8 0.028 14.5 14.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1777) RNA_pol_Rpb8 PF03870.13 MSTRG.10510.1_3 - 1.3e-22 80.3 0.7 1.7e-22 80.0 0.7 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb8 Matrilin_ccoil PF10393.7 MSTRG.10510.1_3 - 0.11 12.2 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin CHZ PF09649.8 MSTRG.24797.1_1 - 8.6 5.8 5.5 7.8 5.9 3.0 2.0 2 0 0 2 2 2 0 Histone chaperone domain CHZ SF3A2 PF16835.3 MSTRG.24944.1_3 - 1.7e-39 134.0 0.1 2.7e-39 133.3 0.1 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.5 MSTRG.24944.1_3 - 3.7e-06 27.0 1.9 3.7e-06 27.0 1.9 1.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.7 MSTRG.24944.1_3 - 0.00056 19.7 0.1 0.00093 19.0 0.1 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein PRP4 PF08799.9 MSTRG.24944.1_3 - 0.1 12.0 3.1 0.17 11.3 3.1 1.3 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like zf-C2H2_jaz PF12171.6 MSTRG.24944.1_3 - 4.7 7.5 6.2 8.8 6.6 4.6 2.3 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding RRM_1 PF00076.20 MSTRG.4349.1_2 - 4.2e-13 48.8 0.0 6.2e-13 48.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RAM PF15320.4 MSTRG.4349.1_2 - 5.4 7.5 15.2 15 6.1 15.2 1.7 1 1 0 1 1 1 0 mRNA cap methylation, RNMT-activating mini protein Methyltransf_31 PF13847.4 MSTRG.21960.1_1 - 4.8e-15 55.5 0.0 7.3e-15 54.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 MSTRG.21960.1_1 - 6e-13 49.2 0.2 1.3e-12 48.2 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.10 MSTRG.21960.1_1 - 8.3e-11 42.4 0.0 1.4e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 MSTRG.21960.1_1 - 2.2e-10 40.6 0.0 3.4e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 MSTRG.21960.1_1 - 6.3e-10 39.4 0.2 1.8e-09 37.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.16 MSTRG.21960.1_1 - 5e-05 22.6 0.0 0.00011 21.5 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family TehB PF03848.12 MSTRG.21960.1_1 - 0.0023 17.2 0.0 0.0053 16.1 0.0 1.5 2 0 0 2 2 2 1 Tellurite resistance protein TehB PCMT PF01135.17 MSTRG.21960.1_1 - 0.034 13.8 0.0 0.057 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.12 MSTRG.21960.1_1 - 0.035 13.5 0.0 0.055 12.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain TPMT PF05724.9 MSTRG.21960.1_1 - 0.073 12.6 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) TSC22 PF01166.16 MSTRG.1010.3_1 - 0.045 13.9 6.1 0.097 12.9 0.1 3.1 2 1 0 2 2 2 0 TSC-22/dip/bun family FPP PF05911.9 MSTRG.1010.3_1 - 0.13 10.4 26.5 0.19 9.8 21.7 2.0 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil DUF1192 PF06698.9 MSTRG.1010.3_1 - 0.99 9.4 4.6 19 5.3 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) PKcGMP_CC PF16808.3 MSTRG.1010.3_1 - 7.5 6.4 13.4 12 5.7 1.0 3.5 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ADIP PF11559.6 MSTRG.1010.3_1 - 9.8 6.1 31.5 3.9 7.4 14.5 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding CALCOCO1 PF07888.9 MSTRG.1010.3_1 - 9.9 4.5 28.6 18 3.6 28.6 1.3 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like CUB PF00431.18 MSTRG.17891.2_2 - 1.3e-16 60.8 0.0 2.3e-16 59.9 0.0 1.4 1 0 0 1 1 1 1 CUB domain PDGF PF00341.15 MSTRG.17891.2_2 - 2.6e-12 46.7 10.5 4.9e-12 45.9 10.5 1.5 1 0 0 1 1 1 1 PDGF/VEGF domain BTB PF00651.29 MSTRG.19148.1_3 - 5.6e-12 45.7 0.0 1.3e-11 44.6 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain COMP PF11598.6 MSTRG.5684.1_1 - 4.9e-11 42.8 2.7 1.1e-10 41.7 2.7 1.6 1 0 0 1 1 1 1 Cartilage oligomeric matrix protein cEGF PF12662.5 MSTRG.5684.1_1 - 3.7e-09 36.2 21.3 4.6e-06 26.3 5.6 3.3 3 0 0 3 3 3 2 Complement Clr-like EGF-like EGF_CA PF07645.13 MSTRG.5684.1_1 - 2.5e-07 30.6 22.2 7.7e-06 25.9 3.6 3.4 3 0 0 3 3 3 2 Calcium-binding EGF domain Laminin_G_2 PF02210.22 MSTRG.5684.1_1 - 0.026 15.0 0.0 0.039 14.4 0.0 1.3 1 0 0 1 1 1 0 Laminin G domain EGF_3 PF12947.5 MSTRG.5684.1_1 - 0.048 13.7 14.5 0.29 11.2 3.9 2.8 2 0 0 2 2 2 0 EGF domain Myosin_head PF00063.19 MSTRG.1426.8_1 - 1.2e-215 717.7 4.8 1.5e-215 717.3 4.8 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.25 MSTRG.1426.8_1 - 5.6e-07 28.7 13.9 0.0025 17.3 0.1 4.5 4 0 0 4 4 4 2 IQ calmodulin-binding motif Yqai PF09466.8 MSTRG.1426.8_1 - 0.13 12.5 0.1 0.36 11.0 0.1 1.7 1 1 0 1 1 1 0 Hypothetical protein Yqai Myosin_TH1 PF06017.11 MSTRG.1426.8_3 - 2.7e-39 134.6 0.5 3.8e-39 134.2 0.5 1.2 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding DUF1049 PF06305.9 MSTRG.1426.8_3 - 1.6 8.5 9.0 4.9 6.9 0.8 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1049) Pkinase PF00069.23 MSTRG.13830.1_2 - 2.8e-63 213.6 0.0 3.6e-63 213.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.13830.1_2 - 8.2e-29 100.5 0.0 1.2e-28 100.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 MSTRG.13830.1_2 - 4.3e-05 22.8 0.1 7e-05 22.1 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 MSTRG.13830.1_2 - 0.012 15.4 0.1 0.081 12.7 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.4 MSTRG.13830.1_2 - 0.087 12.0 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like RasGEF PF00617.17 MSTRG.17878.4_2 - 3.9e-49 167.0 0.1 7.8e-49 166.0 0.1 1.5 1 0 0 1 1 1 1 RasGEF domain PDZ PF00595.22 MSTRG.17878.4_2 - 7.4e-12 45.3 0.1 1.7e-11 44.1 0.1 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) RasGEF_N PF00618.18 MSTRG.17878.4_2 - 3.6e-11 43.1 0.5 5.8e-10 39.2 0.5 2.5 1 1 0 1 1 1 1 RasGEF N-terminal motif RA PF00788.21 MSTRG.17878.4_2 - 2.2e-10 40.9 0.0 6e-10 39.5 0.0 1.8 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PDZ_2 PF13180.4 MSTRG.17878.4_2 - 0.0003 20.9 0.0 0.00078 19.6 0.0 1.6 1 0 0 1 1 1 1 PDZ domain cNMP_binding PF00027.27 MSTRG.17878.4_2 - 0.0013 18.6 0.0 0.0031 17.4 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain LysM PF01476.18 MSTRG.24609.3_1 - 4.4e-08 33.0 0.0 7.3e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 LysM domain GRAM PF02893.18 MSTRG.24609.3_1 - 0.0008 19.1 0.0 0.0014 18.3 0.0 1.3 1 0 0 1 1 1 1 GRAM domain ATP-synt_DE_N PF02823.14 MSTRG.23601.1_1 - 4.1e-16 58.5 0.1 8.5e-16 57.5 0.0 1.6 2 0 0 2 2 2 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Ribosomal_L36 PF00444.16 MSTRG.10819.1_1 - 2e-18 66.1 5.5 3.8e-18 65.3 5.5 1.5 1 0 0 1 1 1 1 Ribosomal protein L36 AAA_2 PF07724.12 MSTRG.25060.3_2 - 3.6e-41 141.0 0.0 5.8e-41 140.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.7 MSTRG.25060.3_2 - 2e-14 53.3 0.1 3.9e-14 52.3 0.1 1.5 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.27 MSTRG.25060.3_2 - 5.3e-13 49.4 0.0 1.4e-12 48.1 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.12 MSTRG.25060.3_2 - 1.9e-05 24.5 0.0 4.1e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.24 MSTRG.25060.3_2 - 0.00014 21.5 0.0 0.00085 18.9 0.0 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain Mg_chelatase PF01078.19 MSTRG.25060.3_2 - 0.00032 20.0 0.0 0.03 13.6 0.0 2.7 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.4 MSTRG.25060.3_2 - 0.00045 20.4 0.1 0.0014 18.8 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.4 MSTRG.25060.3_2 - 0.0076 16.1 0.0 0.02 14.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.15 MSTRG.25060.3_2 - 0.0078 15.9 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.4 MSTRG.25060.3_2 - 0.0097 16.2 0.0 0.025 14.8 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain T2SSE PF00437.18 MSTRG.25060.3_2 - 0.011 14.7 0.0 0.019 13.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein NACHT PF05729.10 MSTRG.25060.3_2 - 0.019 14.8 0.1 0.055 13.3 0.1 1.9 1 1 0 1 1 1 0 NACHT domain TsaE PF02367.15 MSTRG.25060.3_2 - 0.029 14.2 0.0 0.06 13.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activ_2 PF14532.4 MSTRG.25060.3_2 - 0.035 14.1 0.0 0.078 13.0 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain RuvB_N PF05496.10 MSTRG.25060.3_2 - 0.045 12.9 0.0 0.09 11.9 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_18 PF13238.4 MSTRG.25060.3_2 - 0.067 13.6 0.0 0.25 11.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.25 MSTRG.25060.3_2 - 0.07 13.5 0.0 0.18 12.2 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_25 PF13481.4 MSTRG.25060.3_2 - 0.17 11.3 0.1 0.43 10.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain zinc_ribbon_4 PF13717.4 MSTRG.25060.3_2 - 0.46 10.3 5.5 7.5 6.4 0.3 2.5 2 0 0 2 2 2 0 zinc-ribbon domain Sterol-sensing PF12349.6 MSTRG.3598.1_1 - 1.1e-52 177.8 7.2 2e-52 177.0 7.2 1.3 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.16 MSTRG.3598.1_1 - 6.1e-20 70.8 5.3 8.8e-20 70.3 5.3 1.1 1 0 0 1 1 1 1 Patched family WD40 PF00400.30 MSTRG.3598.1_1 - 2.1e-09 37.7 19.6 0.0018 19.0 0.2 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.3598.1_1 - 3.9e-05 23.7 0.0 4 7.7 0.0 3.7 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Methyltransf_15 PF09445.8 MSTRG.28192.1_1 - 0.024 14.3 0.2 1.1 8.9 0.0 2.0 1 1 1 2 2 2 0 RNA cap guanine-N2 methyltransferase Cofilin_ADF PF00241.18 MSTRG.10087.2_3 - 4.4e-09 36.5 0.0 0.00092 19.2 0.0 2.2 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein PPI_Ypi1 PF07491.9 MSTRG.25236.1_3 - 8.9e-21 73.4 4.2 1.7e-20 72.5 4.2 1.4 1 0 0 1 1 1 1 Protein phosphatase inhibitor Pkinase PF00069.23 MSTRG.10204.1_3 - 1.7e-52 178.3 0.0 6.6e-52 176.3 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.10204.1_3 - 1.2e-35 123.0 0.0 2.5e-35 121.9 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase IKKbetaNEMObind PF12179.6 MSTRG.10204.1_3 - 4.4e-16 58.5 7.4 8.3e-16 57.6 6.1 2.3 2 0 0 2 2 2 1 I-kappa-kinase-beta NEMO binding domain Kdo PF06293.12 MSTRG.10204.1_3 - 2.9e-05 23.4 1.2 0.00014 21.1 0.1 2.2 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Connexin PF00029.17 MSTRG.12379.1_1 - 7.1e-81 271.1 5.9 1.1e-80 270.5 5.9 1.3 1 0 0 1 1 1 1 Connexin Sid-5 PF17204.1 MSTRG.12379.1_1 - 0.092 12.8 0.1 0.23 11.5 0.1 1.7 1 0 0 1 1 1 0 Sid-5 family E1_dh PF00676.18 MSTRG.16767.2_1 - 1.7e-91 306.2 0.1 2.2e-91 305.8 0.1 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component Transket_pyr PF02779.22 MSTRG.16767.2_1 - 5.2e-66 221.6 0.0 8.5e-66 220.9 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.3 MSTRG.16767.2_1 - 2.1e-55 186.5 0.0 3.4e-55 185.8 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.3 MSTRG.16767.2_1 - 5.3e-19 67.4 3.1 9.2e-19 66.6 1.0 2.2 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus Sigma54_CBD PF04963.11 MSTRG.16767.2_1 - 0.11 12.2 0.2 11 5.6 0.0 2.8 3 0 0 3 3 3 0 Sigma-54 factor, core binding domain RHD_DNA_bind PF00554.20 MSTRG.2148.1_1 - 2.9e-22 79.3 0.1 2.5e-21 76.2 0.3 2.4 2 1 0 2 2 2 1 Rel homology DNA-binding domain RHD_dimer PF16179.3 MSTRG.2148.1_1 - 9.7e-20 70.4 0.1 2.2e-19 69.3 0.1 1.6 1 0 0 1 1 1 1 Rel homology dimerisation domain TIG PF01833.22 MSTRG.2148.1_1 - 1.9e-06 27.7 0.1 5.5e-06 26.2 0.1 1.9 1 0 0 1 1 1 1 IPT/TIG domain DUF3915 PF13054.4 MSTRG.2148.1_3 - 0.23 11.3 5.5 0.5 10.2 5.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) PT PF04886.10 MSTRG.8873.1_1 - 0.0029 17.0 17.3 0.0029 17.0 17.3 3.9 2 1 1 3 3 3 1 PT repeat PWI PF01480.15 MSTRG.8873.1_3 - 1e-13 51.2 0.4 2e-13 50.3 0.4 1.5 1 0 0 1 1 1 1 PWI domain RRM_1 PF00076.20 MSTRG.8873.1_3 - 9.5e-08 31.6 0.0 1.8e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MOZ_SAS PF01853.16 MSTRG.21716.1_1 - 0.018 14.6 0.0 0.03 13.8 0.0 1.4 1 0 0 1 1 1 0 MOZ/SAS family Fanconi_C PF02106.13 MSTRG.12212.1_3 - 7.6e-45 153.5 0.0 8.5e-45 153.4 0.0 1.0 1 0 0 1 1 1 1 Fanconi anaemia group C protein TMEM189_B_dmain PF10520.7 MSTRG.12212.1_3 - 0.039 14.0 0.0 0.071 13.1 0.0 1.4 1 0 0 1 1 1 0 B domain of TMEM189, localisation domain Neocarzinostat PF00960.16 MSTRG.12212.1_3 - 0.067 13.1 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Neocarzinostatin family Pkinase PF00069.23 MSTRG.22107.2_2 - 1.7e-72 243.8 0.0 2.4e-72 243.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.22107.2_2 - 5.2e-39 134.0 0.0 6.8e-39 133.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 MSTRG.22107.2_2 - 0.00033 20.5 0.0 0.0018 18.1 0.0 2.0 2 1 1 3 3 3 1 Phosphotransferase enzyme family Choline_kinase PF01633.18 MSTRG.22107.2_2 - 0.022 14.2 0.1 0.042 13.3 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kinase-like PF14531.4 MSTRG.22107.2_2 - 0.027 13.7 0.0 0.041 13.0 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.12 MSTRG.22107.2_2 - 0.043 13.0 0.0 0.074 12.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ank_2 PF12796.5 MSTRG.12867.3_2 - 1.7e-48 163.0 8.4 3.8e-15 56.1 0.0 5.0 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.12867.3_2 - 2.1e-45 151.9 14.0 2.5e-12 46.7 0.0 6.9 3 1 4 7 7 7 7 Ankyrin repeats (many copies) MIB_HERC2 PF06701.11 MSTRG.12867.3_2 - 9.2e-44 147.4 22.3 3.9e-27 94.2 5.4 3.7 4 0 0 4 4 4 2 Mib_herc2 Ank_4 PF13637.4 MSTRG.12867.3_2 - 1.6e-41 140.0 16.4 2.9e-11 43.5 0.1 7.3 2 1 6 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.12867.3_2 - 3e-41 138.0 3.4 2.1e-07 31.0 0.6 9.0 8 1 0 8 8 8 8 Ankyrin repeat Ank_3 PF13606.4 MSTRG.12867.3_2 - 3.4e-30 100.6 8.4 0.0018 18.5 0.1 10.1 10 0 0 10 10 9 6 Ankyrin repeat zf-C3HC4_3 PF13920.4 MSTRG.12867.3_2 - 9.1e-27 92.6 58.7 4.3e-10 39.2 7.4 4.5 4 0 0 4 4 4 3 Zinc finger, C3HC4 type (RING finger) ZZ PF00569.15 MSTRG.12867.3_2 - 1.7e-11 43.6 8.7 1.7e-11 43.6 8.7 3.4 3 0 0 3 3 2 1 Zinc finger, ZZ type zf-C3HC4_2 PF13923.4 MSTRG.12867.3_2 - 7.7e-08 31.9 10.5 7.7e-08 31.9 10.5 4.6 2 1 2 4 4 4 2 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 MSTRG.12867.3_2 - 0.0014 18.3 56.2 0.017 14.9 8.1 4.9 4 1 1 5 5 4 3 Prokaryotic RING finger family 4 Vps39_2 PF10367.7 MSTRG.12867.3_2 - 2.7 8.3 12.3 0.064 13.5 0.4 3.9 3 1 1 4 4 4 0 Vacuolar sorting protein 39 domain 2 Peptidase_C14 PF00656.20 MSTRG.27502.1_1 - 6.7e-48 163.7 0.0 8.5e-48 163.3 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Guanylate_kin PF00625.19 MSTRG.12794.1_3 - 1.2e-65 220.5 0.0 1.6e-65 220.1 0.0 1.1 1 0 0 1 1 1 1 Guanylate kinase AAA_18 PF13238.4 MSTRG.12794.1_3 - 2.8e-05 24.5 0.1 6.5e-05 23.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 MSTRG.12794.1_3 - 8.3e-05 22.9 0.1 0.00015 22.1 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.4 MSTRG.12794.1_3 - 0.00027 21.0 0.3 0.0022 18.0 0.3 2.2 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.25 MSTRG.12794.1_3 - 0.00048 20.5 0.0 0.0009 19.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter DUF258 PF03193.14 MSTRG.12794.1_3 - 0.00062 19.6 0.0 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.4 MSTRG.12794.1_3 - 0.0045 17.1 0.0 0.0087 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.21 MSTRG.12794.1_3 - 0.0058 16.6 0.1 0.017 15.1 0.1 1.8 2 1 0 2 2 1 1 50S ribosome-binding GTPase NACHT PF05729.10 MSTRG.12794.1_3 - 0.0067 16.2 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_29 PF13555.4 MSTRG.12794.1_3 - 0.0082 15.7 0.1 0.015 14.9 0.1 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain RNA_helicase PF00910.20 MSTRG.12794.1_3 - 0.009 16.3 0.0 0.017 15.3 0.0 1.5 1 0 0 1 1 1 1 RNA helicase NTPase_1 PF03266.13 MSTRG.12794.1_3 - 0.021 14.6 0.0 0.032 14.0 0.0 1.2 1 0 0 1 1 1 0 NTPase AAA_14 PF13173.4 MSTRG.12794.1_3 - 0.023 14.6 0.0 0.042 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.4 MSTRG.12794.1_3 - 0.028 14.7 0.2 0.064 13.5 0.0 1.7 2 0 0 2 2 1 0 AAA domain cobW PF02492.17 MSTRG.12794.1_3 - 0.035 13.6 0.1 0.072 12.5 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.27 MSTRG.12794.1_3 - 0.041 14.2 0.0 0.075 13.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.4 MSTRG.12794.1_3 - 0.041 14.0 0.0 0.065 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.4 MSTRG.12794.1_3 - 0.049 13.2 0.0 0.075 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain TsaE PF02367.15 MSTRG.12794.1_3 - 0.058 13.3 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.10 MSTRG.12794.1_3 - 0.059 12.5 0.1 0.1 11.7 0.1 1.3 1 0 0 1 1 1 0 Zeta toxin KAP_NTPase PF07693.12 MSTRG.12794.1_3 - 0.081 12.0 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain DUF815 PF05673.11 MSTRG.12794.1_3 - 0.091 11.8 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_24 PF13479.4 MSTRG.12794.1_3 - 0.13 11.9 0.4 0.76 9.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain FAM194 PF14977.4 MSTRG.8395.1_1 - 1.5e-12 47.1 0.0 2.1e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 FAM194 protein Bcl-2 PF00452.17 MSTRG.21265.2_2 - 4.4e-16 59.2 0.6 6e-16 58.7 0.6 1.2 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family CBM49 PF09478.8 MSTRG.2512.1_3 - 0.032 14.4 0.0 0.047 13.9 0.0 1.2 1 0 0 1 1 1 0 Carbohydrate binding domain CBM49 Pkinase PF00069.23 MSTRG.19555.1_1 - 2.4e-45 154.8 0.0 3e-45 154.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.19555.1_1 - 3.1e-40 138.0 0.0 3.8e-40 137.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Methyltr_RsmB-F PF01189.15 MSTRG.10825.1_1 - 2.7e-36 125.0 0.0 2.1e-35 122.0 0.0 2.1 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Ank_2 PF12796.5 MSTRG.16427.3_2 - 7.5e-17 61.6 0.1 1.3e-16 60.8 0.1 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.16427.3_2 - 2.2e-16 59.8 1.0 6.9e-12 45.5 0.5 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.16427.3_2 - 6e-13 48.5 1.5 3.1e-05 24.1 0.2 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.4 MSTRG.16427.3_2 - 5.7e-12 44.6 0.7 4.8e-05 23.3 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeat SH3_1 PF00018.26 MSTRG.16427.3_2 - 1.2e-10 40.7 0.9 2.1e-10 39.9 0.9 1.4 1 0 0 1 1 1 1 SH3 domain Ank_5 PF13857.4 MSTRG.16427.3_2 - 1.2e-09 38.1 0.4 3.2e-07 30.4 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SH3_9 PF14604.4 MSTRG.16427.3_2 - 1.6e-09 37.3 0.4 3.4e-09 36.3 0.4 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.16427.3_2 - 5e-06 26.0 0.0 1e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain IncA PF04156.12 MSTRG.16427.3_2 - 1.3 8.6 29.4 0.26 10.9 17.2 2.5 2 0 0 2 2 2 0 IncA protein NEMP PF10225.7 MSTRG.16427.3_2 - 2.6 7.6 4.1 4.8 6.7 4.1 1.3 1 0 0 1 1 1 0 NEMP family ATP-gua_Ptrans PF00217.17 MSTRG.11140.1_2 - 4.7e-32 111.4 0.0 5.1e-32 111.3 0.0 1.0 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain zf-C3HC4_3 PF13920.4 MSTRG.13855.1_1 - 2.5e-08 33.5 4.3 2.5e-08 33.5 4.3 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) SWIB PF02201.16 MSTRG.13855.1_1 - 4e-07 29.7 0.0 6.4e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 SWIB/MDM2 domain zf-RanBP PF00641.16 MSTRG.13855.1_1 - 8.3e-07 28.1 4.7 3.2e-06 26.2 4.7 2.1 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Pkinase_Tyr PF07714.15 MSTRG.7267.2_1 - 9.2e-90 300.3 0.0 1.4e-89 299.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.7267.2_1 - 2.3e-43 148.3 0.0 3.6e-43 147.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 MSTRG.7267.2_1 - 2.7e-22 78.5 0.0 6.1e-22 77.3 0.0 1.6 1 0 0 1 1 1 1 SH2 domain PH PF00169.27 MSTRG.7267.2_1 - 5.5e-17 62.1 0.4 1.2e-16 61.0 0.4 1.6 1 0 0 1 1 1 1 PH domain BTK PF00779.17 MSTRG.7267.2_1 - 3.7e-14 52.1 1.4 9.3e-14 50.8 1.4 1.8 1 0 0 1 1 1 1 BTK motif SH3_1 PF00018.26 MSTRG.7267.2_1 - 1.1e-12 47.2 0.1 2.8e-12 45.9 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.7267.2_1 - 6.1e-06 25.7 0.0 1.5e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 MSTRG.7267.2_1 - 2.1e-05 24.1 0.0 4.6e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Kinase-like PF14531.4 MSTRG.7267.2_1 - 0.0068 15.6 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like PH_11 PF15413.4 MSTRG.7267.2_1 - 0.0069 16.7 0.5 0.019 15.3 0.5 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.4 MSTRG.7267.2_1 - 0.011 15.6 1.2 0.035 14.1 1.2 1.8 1 1 0 1 1 1 0 PH domain APH PF01636.21 MSTRG.7267.2_1 - 0.013 15.3 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family SH3_3 PF08239.9 MSTRG.7267.2_1 - 0.044 13.9 0.4 0.084 13.0 0.4 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain HECT PF00632.23 MSTRG.15124.2_3 - 3.1e-101 338.8 0.1 4.3e-101 338.3 0.1 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.24 MSTRG.15124.2_3 - 7.4e-51 169.6 27.1 1.6e-12 47.0 4.4 4.8 4 0 0 4 4 4 4 WW domain C2 PF00168.28 MSTRG.15124.2_3 - 1.8e-24 85.9 0.1 5.9e-24 84.2 0.0 1.9 2 0 0 2 2 2 1 C2 domain DUF4516 PF14990.4 MSTRG.22497.1_2 - 5.4e-23 80.3 0.8 1.1e-22 79.3 0.8 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4516) WW PF00397.24 MSTRG.26150.1_3 - 2.9e-09 36.6 0.5 4.6e-09 35.9 0.5 1.3 1 0 0 1 1 1 1 WW domain FAM181 PF15238.4 MSTRG.26150.1_3 - 0.00023 21.0 5.3 0.0003 20.6 5.3 1.3 1 0 0 1 1 1 1 FAM181 Acyl_transf_1 PF00698.19 MSTRG.15249.1_3 - 1.9e-20 73.5 0.0 2.8e-20 72.9 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain Lectin_C PF00059.19 MSTRG.3514.1_1 - 3.8e-16 59.6 0.0 5.5e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.10 MSTRG.3514.1_1 - 0.0002 21.0 0.0 0.00026 20.6 0.0 1.2 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Ndr PF03096.12 MSTRG.12288.1_2 - 4.2e-119 396.3 0.0 5.6e-119 395.9 0.0 1.2 1 0 0 1 1 1 1 Ndr family Abhydrolase_1 PF00561.18 MSTRG.12288.1_2 - 4.9e-05 23.0 0.1 8.9e-05 22.1 0.1 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 MSTRG.12288.1_2 - 0.049 12.8 0.0 0.073 12.2 0.0 1.1 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Requiem_N PF14051.4 MSTRG.9383.1_2 - 9e-36 121.8 2.9 2.3e-35 120.5 2.9 1.8 1 0 0 1 1 1 1 N-terminal domain of DPF2/REQ. PHD PF00628.27 MSTRG.9383.1_2 - 5.2e-19 67.8 22.2 1.3e-10 40.9 8.2 2.9 1 1 1 2 2 2 2 PHD-finger PHD_4 PF16866.3 MSTRG.9383.1_2 - 0.72 9.9 20.7 0.044 13.7 8.7 2.8 1 1 1 2 2 2 0 PHD-finger PHD_2 PF13831.4 MSTRG.9383.1_2 - 2.8 7.4 16.1 0.15 11.5 1.4 2.9 2 1 0 2 2 2 0 PHD-finger Lar_restr_allev PF14354.4 MSTRG.9383.1_2 - 3.2 8.1 16.6 1.2e+03 -0.1 16.6 2.9 1 1 0 1 1 1 0 Restriction alleviation protein Lar Sec7 PF01369.18 MSTRG.10971.3_2 - 3.8e-68 228.7 0.1 6.3e-68 228.0 0.1 1.4 1 0 0 1 1 1 1 Sec7 domain PH PF00169.27 MSTRG.10971.3_2 - 1.3e-27 96.2 0.1 2.4e-27 95.3 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 MSTRG.10971.3_2 - 8.3e-05 22.8 0.0 0.00017 21.9 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.4 MSTRG.10971.3_2 - 0.011 15.9 0.0 0.029 14.5 0.0 1.7 2 0 0 2 2 2 0 Pleckstrin homology domain PH_3 PF14593.4 MSTRG.10971.3_2 - 0.025 14.5 0.0 0.054 13.5 0.0 1.6 1 0 0 1 1 1 0 PH domain GPS2_interact PF15784.3 MSTRG.10971.3_2 - 0.092 13.3 2.2 0.18 12.3 2.2 1.4 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain APG6 PF04111.10 MSTRG.10971.3_2 - 0.97 8.6 4.3 0.88 8.8 2.9 1.6 2 0 0 2 2 2 0 Autophagy protein Apg6 FA_hydroxylase PF04116.11 MSTRG.12605.1_3 - 2.7e-27 95.6 12.8 2.7e-27 95.6 12.8 2.8 2 2 1 3 3 3 1 Fatty acid hydroxylase superfamily IncA PF04156.12 MSTRG.1138.1_1 - 0.00059 19.6 0.1 0.00094 18.9 0.1 1.3 1 0 0 1 1 1 1 IncA protein EphA2_TM PF14575.4 MSTRG.1138.1_1 - 0.013 16.1 0.1 0.027 15.1 0.1 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain LYRIC PF15686.3 MSTRG.1138.1_1 - 0.031 13.7 0.1 0.045 13.2 0.1 1.1 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family Myc_target_1 PF15179.4 MSTRG.1138.1_1 - 0.049 13.4 0.4 0.097 12.4 0.0 1.7 2 0 0 2 2 2 0 Myc target protein 1 PAG PF15347.4 MSTRG.1138.1_1 - 0.052 12.4 0.8 0.076 11.9 0.8 1.1 1 0 0 1 1 1 0 Phosphoprotein associated with glycosphingolipid-enriched TMEM51 PF15345.4 MSTRG.1138.1_1 - 0.072 12.8 0.7 0.13 12.0 0.7 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 TIMP PF00965.15 MSTRG.23482.1_2 - 1.1e-63 214.2 8.6 1.7e-63 213.6 8.6 1.3 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase LIME1 PF15332.4 MSTRG.6595.1_3 - 1.2e-10 41.2 2.2 1.4e-10 40.9 1.4 1.6 1 1 0 1 1 1 1 Lck-interacting transmembrane adapter 1 zf-C2H2 PF00096.24 MSTRG.20446.1_3 - 0.0011 19.2 0.2 0.0011 19.2 0.2 5.2 6 0 0 6 6 6 1 Zinc finger, C2H2 type zf-Di19 PF05605.10 MSTRG.20446.1_3 - 0.0017 18.5 1.5 0.0017 18.5 1.5 3.7 4 0 0 4 4 4 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.4 MSTRG.20446.1_3 - 0.0053 17.4 0.3 0.0053 17.4 0.3 5.3 6 0 0 6 6 6 2 C2H2-type zinc finger C1_2 PF03107.14 MSTRG.20446.1_3 - 0.19 12.0 10.7 0.67 10.2 1.9 3.5 2 1 1 3 3 3 0 C1 domain Zf_RING PF16744.3 MSTRG.20446.1_3 - 0.54 10.3 3.9 2.5 8.2 0.1 3.0 2 1 0 2 2 2 0 KIAA1045 RING finger C1_4 PF07975.10 MSTRG.20446.1_3 - 0.83 9.8 8.5 5.8 7.1 0.0 3.7 3 1 0 3 3 3 0 TFIIH C1-like domain Elf1 PF05129.11 MSTRG.20446.1_3 - 1 9.3 7.7 0.19 11.7 1.0 2.8 3 0 0 3 3 3 0 Transcription elongation factor Elf1 like zinc-ribbons_6 PF07191.10 MSTRG.20446.1_3 - 2.6 8.0 10.4 29 4.6 6.8 3.3 2 1 0 2 2 2 0 zinc-ribbons zf-C2H2_jaz PF12171.6 MSTRG.20446.1_3 - 8.8 6.6 9.6 13 6.1 0.1 3.8 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding I-set PF07679.14 MSTRG.12795.2_3 - 0 1548.8 130.5 1.2e-20 73.2 0.0 41.6 41 0 0 41 41 41 40 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.12795.2_3 - 0 1105.1 110.5 1.3e-13 51.2 0.0 40.5 40 0 0 40 40 40 37 Immunoglobulin domain ig PF00047.23 MSTRG.12795.2_3 - 1.2e-264 855.3 140.7 4.4e-11 42.7 0.4 38.5 39 0 0 39 39 39 32 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.12795.2_3 - 2.7e-235 761.3 93.4 1e-08 35.3 0.2 37.8 31 2 7 38 38 38 32 Immunoglobulin domain V-set PF07686.15 MSTRG.12795.2_3 - 1.2e-91 302.0 147.8 0.00079 19.4 0.0 53.5 36 22 1 39 39 37 27 Immunoglobulin V-set domain Ig_5 PF16681.3 MSTRG.12795.2_3 - 6.8e-49 164.1 103.6 0.014 15.7 0.1 30.9 32 0 0 32 32 32 16 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 MSTRG.12795.2_3 - 2.4e-34 117.1 82.3 0.17 11.8 0.0 32.2 35 0 0 35 35 34 8 Izumo-like Immunoglobulin domain Ig_4 PF16680.3 MSTRG.12795.2_3 - 5.4e-25 87.4 121.7 0.018 15.3 0.2 30.9 30 0 0 30 30 29 8 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.10 MSTRG.12795.2_3 - 1.6e-21 76.0 60.3 0.55 10.2 0.0 26.6 28 0 0 28 28 28 5 CD80-like C2-set immunoglobulin domain RhoGEF PF00621.18 MSTRG.12795.2_3 - 2.8e-18 66.7 0.0 7.5e-18 65.3 0.0 1.7 1 0 0 1 1 1 1 RhoGEF domain BiPBP_C PF06832.10 MSTRG.12795.2_3 - 5.7e-15 55.0 1.2 8.3 6.4 0.0 15.2 19 0 0 19 19 15 1 Penicillin-Binding Protein C-terminus Family fn3 PF00041.19 MSTRG.12795.2_3 - 1.1e-14 54.4 0.4 1.4e-12 47.6 0.0 4.6 4 0 0 4 4 3 1 Fibronectin type III domain C1-set PF07654.13 MSTRG.12795.2_3 - 9.7e-13 48.3 85.1 0.019 15.3 0.2 25.6 29 0 0 29 29 28 5 Immunoglobulin C1-set domain Adeno_E3_CR1 PF02440.13 MSTRG.12795.2_3 - 1.7e-06 27.6 62.5 2.7 7.7 0.1 18.8 21 0 0 21 21 20 3 Adenovirus E3 region protein CR1 PH PF00169.27 MSTRG.12795.2_3 - 1.8e-06 28.3 3.2 3.7e-06 27.3 0.2 3.4 3 0 0 3 3 1 1 PH domain PKD_3 PF16820.3 MSTRG.12795.2_3 - 2.4e-06 27.1 0.8 11 5.7 0.0 8.4 9 0 0 9 9 9 0 PKD-like domain Receptor_2B4 PF11465.6 MSTRG.12795.2_3 - 2.8e-05 24.1 20.2 1.4 9.0 0.0 12.3 17 0 0 17 17 15 1 Natural killer cell receptor 2B4 IQ PF00612.25 MSTRG.12795.2_3 - 5.2e-05 22.6 0.5 0.00012 21.4 0.5 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif ACAS_N PF16177.3 MSTRG.12795.2_3 - 7.7e-05 22.4 0.3 9.7 6.1 0.0 7.4 7 0 0 7 7 6 0 Acetyl-coenzyme A synthetase N-terminus Actin PF00022.17 MSTRG.28621.1_3 - 3.5e-46 157.5 0.1 2.2e-45 154.9 0.1 1.8 1 1 0 1 1 1 1 Actin N_Asn_amidohyd PF14736.4 MSTRG.19014.2_1 - 1.5e-106 355.4 0.1 8.9e-106 352.8 0.1 1.9 1 1 0 1 1 1 1 Protein N-terminal asparagine amidohydrolase T-box PF00907.20 MSTRG.16606.1_3 - 1.6e-79 266.3 0.1 2.2e-79 265.8 0.1 1.2 1 0 0 1 1 1 1 T-box p450 PF00067.20 MSTRG.2708.1_3 - 3.5e-101 339.1 0.0 4.1e-101 338.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PQ-loop PF04193.12 MSTRG.2708.1_3 - 0.0047 16.5 0.2 2 8.1 0.1 2.4 2 0 0 2 2 2 2 PQ loop repeat Hormone_recep PF00104.28 MSTRG.20060.1_2 - 2.3e-45 154.6 0.6 3.9e-45 153.9 0.6 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 MSTRG.20060.1_2 - 1.8e-31 108.2 17.3 3.4e-31 107.4 17.3 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) ATP-synt_G PF04718.13 MSTRG.22788.2_1 - 7.1e-24 84.4 0.0 9.5e-24 84.0 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ATP synthase g subunit Laminin_G_2 PF02210.22 MSTRG.21610.1_3 - 9.7e-08 32.5 0.0 1.5e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.21 MSTRG.21610.1_3 - 9.9e-05 22.4 0.0 0.00016 21.7 0.0 1.2 1 0 0 1 1 1 1 Laminin G domain Laminin_G_3 PF13385.4 MSTRG.21610.1_3 - 0.00067 19.7 0.0 0.00095 19.2 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily CSD PF00313.20 MSTRG.3266.2_2 - 1.1e-79 262.2 21.5 2.2e-16 59.3 0.5 9.3 9 0 0 9 9 9 9 'Cold-shock' DNA-binding domain S1-like PF14444.4 MSTRG.3266.2_2 - 1.1e-10 41.2 15.3 0.031 14.2 0.0 8.1 9 1 0 9 9 9 4 S1-like SUZ-C PF12901.5 MSTRG.3266.2_2 - 8.5e-10 38.3 0.1 2.4e-09 36.9 0.0 1.9 2 0 0 2 2 2 1 SUZ-C motif CusF_Ec PF11604.6 MSTRG.3266.2_2 - 6.9e-08 32.2 12.5 0.17 11.7 0.1 8.9 10 0 0 10 10 10 1 Copper binding periplasmic protein CusF DUF3857 PF12969.5 MSTRG.3266.2_2 - 0.018 15.0 0.0 0.66 9.9 0.0 3.0 3 0 0 3 3 3 0 Domain of Unknown Function with PDB structure (DUF3857) RsgA_N PF16745.3 MSTRG.3266.2_2 - 0.021 14.4 8.8 4.8 6.9 0.0 6.2 7 0 0 7 7 7 0 RsgA N-terminal domain MazE_antitoxin PF04014.16 MSTRG.3266.2_2 - 0.09 12.6 7.0 9.2 6.2 0.1 4.7 5 0 0 5 5 5 0 Antidote-toxin recognition MazE, bacterial antitoxin OB_RNB PF08206.9 MSTRG.3266.2_2 - 3.5 7.2 17.1 18 5.0 0.3 5.4 6 0 0 6 6 6 0 Ribonuclease B OB domain Peptidase_M18 PF02127.13 MSTRG.20068.2_2 - 4.2e-179 595.7 0.0 5e-179 595.5 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.12 MSTRG.20068.2_2 - 3.6e-08 32.6 0.0 8.8e-07 28.1 0.1 2.1 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase RRM_1 PF00076.20 MSTRG.20036.4_3 - 2.5e-37 126.4 0.0 5e-23 80.6 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.4 MSTRG.20036.4_3 - 2.3e-26 92.5 0.2 4.9e-26 91.5 0.2 1.6 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.3 MSTRG.20036.4_3 - 0.0044 16.7 0.0 0.054 13.2 0.0 2.6 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_5 PF13893.4 MSTRG.20036.4_3 - 0.037 13.5 0.0 0.36 10.3 0.0 2.1 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer PF06495.9 MSTRG.20036.4_3 - 0.88 9.5 37.6 0.03 14.3 30.9 1.9 2 0 0 2 2 2 0 Fruit fly transformer protein Apt1 PF10351.7 MSTRG.20036.4_3 - 3.7 6.2 10.9 5.3 5.7 10.9 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF1777 PF08648.10 MSTRG.20036.4_3 - 5.7 7.0 36.9 9.1 6.4 36.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) MIP-T3 PF10243.7 MSTRG.20036.4_3 - 7.3 5.0 26.9 11 4.5 26.9 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Arm PF00514.21 MSTRG.6245.1_1 - 3.8e-38 128.3 6.2 2.5e-10 39.9 0.0 7.3 7 0 0 7 7 7 6 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.4 MSTRG.6245.1_1 - 5.7e-09 36.1 5.2 0.15 12.4 0.1 5.3 5 1 0 5 5 5 3 HEAT-like repeat HEAT_2 PF13646.4 MSTRG.6245.1_1 - 2.7e-08 34.0 0.5 0.011 16.0 0.0 2.9 2 0 0 2 2 2 2 HEAT repeats HEAT PF02985.20 MSTRG.6245.1_1 - 9.9e-07 28.4 3.5 1.6 9.1 0.4 5.3 5 0 0 5 5 5 2 HEAT repeat Arm_2 PF04826.11 MSTRG.6245.1_1 - 0.00058 19.3 0.3 0.016 14.6 0.0 2.8 4 0 0 4 4 4 1 Armadillo-like Atx10homo_assoc PF09759.7 MSTRG.6245.1_1 - 0.0013 18.6 1.1 0.036 14.0 0.1 3.1 3 1 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain V-ATPase_H_N PF03224.12 MSTRG.6245.1_1 - 0.23 10.6 0.7 11 5.0 0.0 2.8 2 1 1 3 3 3 0 V-ATPase subunit H Filament PF00038.19 MSTRG.19925.1_2 - 2e-71 241.0 28.5 2.3e-71 240.8 28.5 1.0 1 0 0 1 1 1 1 Intermediate filament protein Phage_GP20 PF06810.9 MSTRG.19925.1_2 - 0.011 15.4 0.8 0.024 14.3 0.8 1.5 1 0 0 1 1 1 0 Phage minor structural protein GP20 Fib_alpha PF08702.8 MSTRG.19925.1_2 - 0.026 14.6 2.8 0.09 12.8 0.0 2.7 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.10 MSTRG.19925.1_2 - 0.062 13.1 1.8 0.077 12.8 0.0 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Tup_N PF08581.8 MSTRG.19925.1_2 - 0.31 11.3 13.8 0.21 11.8 1.8 4.6 4 2 1 5 5 5 0 Tup N-terminal TACC PF05010.12 MSTRG.19925.1_2 - 0.36 10.4 10.7 0.36 10.5 1.0 2.3 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC) BRF1 PF07741.11 MSTRG.19925.1_2 - 4.6 7.5 7.4 1.1 9.4 3.2 2.1 2 0 0 2 2 2 0 Brf1-like TBP-binding domain zf-H2C2_2 PF13465.4 MSTRG.23887.1_2 - 2.7e-21 74.8 26.7 1.1e-06 28.7 0.5 5.5 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.23887.1_2 - 5.3e-13 48.5 26.6 0.0029 17.9 2.1 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.23887.1_2 - 1.4e-12 47.2 25.7 0.0082 16.8 2.0 4.7 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2HE PF16278.3 MSTRG.23887.1_2 - 4.8e-05 23.6 17.5 0.00017 21.8 1.8 4.0 3 1 1 4 4 3 1 C2HE / C2H2 / C2HC zinc-binding finger zf-Di19 PF05605.10 MSTRG.23887.1_2 - 0.019 15.1 12.7 0.16 12.2 3.3 2.7 1 1 2 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding GAGA PF09237.9 MSTRG.23887.1_2 - 0.025 14.3 4.1 10 5.9 0.1 3.7 1 1 2 3 3 3 0 GAGA factor zf-C2H2_6 PF13912.4 MSTRG.23887.1_2 - 0.027 14.3 0.6 0.027 14.3 0.6 4.8 4 1 0 4 4 4 0 C2H2-type zinc finger zf-H2C2_5 PF13909.4 MSTRG.23887.1_2 - 0.068 12.8 0.2 0.068 12.8 0.2 5.5 5 1 0 5 5 5 0 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.5 MSTRG.23887.1_2 - 0.087 13.0 16.2 7.4 6.8 0.3 4.2 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) BolA PF01722.16 MSTRG.23887.1_2 - 0.1 12.8 2.2 0.93 9.7 0.1 2.4 2 0 0 2 2 2 0 BolA-like protein Zn-ribbon_8 PF09723.8 MSTRG.23887.1_2 - 0.11 12.5 6.2 3.6 7.6 0.7 3.7 3 0 0 3 3 3 0 Zinc ribbon domain zf-C2H2_11 PF16622.3 MSTRG.23887.1_2 - 0.17 11.5 0.2 0.17 11.5 0.2 3.9 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 MSTRG.23887.1_2 - 0.19 12.0 14.7 4 7.7 0.1 4.4 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding Zf_RING PF16744.3 MSTRG.23887.1_2 - 0.46 10.5 6.9 2.2 8.3 0.1 3.8 1 1 2 3 3 3 0 KIAA1045 RING finger TSC22 PF01166.16 MSTRG.23887.1_2 - 0.52 10.5 3.9 1.5 9.1 3.9 1.7 1 0 0 1 1 1 0 TSC-22/dip/bun family zf-UBP PF02148.17 MSTRG.23887.1_2 - 1.1 9.6 12.1 55 4.1 12.1 2.8 1 1 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein zf-C2H2_8 PF15909.3 MSTRG.23887.1_2 - 1.5 9.1 12.9 3.8 7.7 3.6 2.4 1 1 1 2 2 2 0 C2H2-type zinc ribbon Ephrin_rec_like PF07699.11 MSTRG.23887.1_2 - 2.3 7.9 6.6 6.7 6.4 1.5 3.0 3 1 0 3 3 2 0 Putative ephrin-receptor like C1_2 PF03107.14 MSTRG.23887.1_2 - 8.5 6.6 14.7 3.2e+02 1.6 0.2 4.3 2 1 0 2 2 2 0 C1 domain EB1 PF03271.15 MSTRG.12819.1_2 - 4.7e-15 55.4 0.4 1.2e-14 54.1 0.4 1.7 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.29 MSTRG.12819.1_2 - 5.7e-11 42.4 0.2 9.1e-11 41.8 0.2 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 MSTRG.12819.1_2 - 0.021 14.5 0.0 0.046 13.4 0.0 1.5 1 0 0 1 1 1 0 CAMSAP CH domain GTP-bdg_M PF16360.3 MSTRG.12819.1_2 - 0.086 13.3 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 GTP-binding GTPase Middle Region Suppressor_APC PF11414.6 MSTRG.12819.1_2 - 0.1 12.5 0.1 0.21 11.5 0.1 1.4 1 0 0 1 1 1 0 Adenomatous polyposis coli tumour suppressor protein MIS13 PF08202.9 MSTRG.12819.1_2 - 0.1 11.7 0.1 0.16 11.1 0.1 1.2 1 0 0 1 1 1 0 Mis12-Mtw1 protein family tRNA_anti-codon PF01336.23 MSTRG.26422.1_1 - 0.18 11.7 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain TRIQK PF15168.4 MSTRG.23274.1_2 - 1.2e-37 127.6 0.7 2.3e-37 126.6 0.7 1.5 1 0 0 1 1 1 1 Triple QxxK/R motif-containing protein family Baculo_11_kDa PF06143.9 MSTRG.23274.1_2 - 0.041 13.3 0.0 0.093 12.2 0.0 1.6 1 0 0 1 1 1 0 Baculovirus 11 kDa family Wbp11 PF09429.8 MSTRG.23274.1_2 - 0.066 13.5 0.5 0.066 13.5 0.5 2.2 2 0 0 2 2 2 0 WW domain binding protein 11 FH2 PF02181.21 MSTRG.7575.2_1 - 1.8e-77 260.8 11.3 3e-77 260.1 11.3 1.4 1 0 0 1 1 1 1 Formin Homology 2 Domain Drf_FH3 PF06367.14 MSTRG.7575.2_1 - 1.7e-29 102.7 1.1 1.7e-29 102.7 1.1 2.4 2 0 0 2 2 2 1 Diaphanous FH3 Domain Drf_GBD PF06371.11 MSTRG.7575.2_1 - 2.3e-16 59.8 1.7 1.5e-15 57.2 0.0 2.4 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain WH2 PF02205.18 MSTRG.7575.2_1 - 0.0031 17.2 0.0 0.0067 16.1 0.0 1.6 1 0 0 1 1 1 1 WH2 motif DUF3361 PF11841.6 MSTRG.7575.2_1 - 0.031 14.1 3.1 1.3 8.8 0.1 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF3361) ALMT PF11744.6 MSTRG.7575.2_1 - 0.035 12.8 2.2 0.06 12.0 2.2 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Exonuc_VII_L PF02601.13 MSTRG.7575.2_1 - 5 6.5 8.6 0.42 10.0 3.4 1.8 2 0 0 2 2 2 0 Exonuclease VII, large subunit IBN_N PF03810.17 MSTRG.9053.1_3 - 2.9e-18 65.4 0.1 1.5e-17 63.1 0.0 2.4 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT_2 PF13646.4 MSTRG.9053.1_3 - 0.045 14.0 0.0 0.21 11.9 0.0 2.1 2 0 0 2 2 2 0 HEAT repeats HEAT PF02985.20 MSTRG.9053.1_3 - 0.11 12.7 0.3 20 5.6 0.0 3.6 3 0 0 3 3 3 0 HEAT repeat Xpo1 PF08389.10 MSTRG.9053.1_3 - 0.24 11.3 0.1 0.24 11.3 0.1 4.3 5 0 0 5 5 5 0 Exportin 1-like protein SH3_4 PF06347.11 MSTRG.22459.1_1 - 0.051 13.3 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain ANF_receptor PF01094.26 MSTRG.22459.1_2 - 1.5e-66 224.7 0.4 1.8e-66 224.5 0.4 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.4 MSTRG.22459.1_2 - 3.5e-08 33.4 0.0 4.7e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein V-set PF07686.15 MSTRG.7884.1_3 - 0.0034 17.4 0.0 3 7.9 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin V-set domain PID PF00640.21 MSTRG.11409.1_1 - 9.4e-48 161.7 0.0 3.8e-36 124.0 0.0 2.7 3 0 0 3 3 3 2 Phosphotyrosine interaction domain (PTB/PID) WW PF00397.24 MSTRG.11409.1_1 - 1.1e-06 28.3 0.4 2.3e-06 27.3 0.4 1.6 1 0 0 1 1 1 1 WW domain PTB PF08416.11 MSTRG.11409.1_1 - 5.8e-05 23.1 0.0 0.00043 20.3 0.0 2.1 2 0 0 2 2 2 1 Phosphotyrosine-binding domain Cyclin PF08613.9 MSTRG.12465.1_2 - 9e-05 22.8 0.0 0.00014 22.1 0.0 1.2 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.21 MSTRG.12465.1_2 - 0.00017 21.2 0.0 0.00028 20.6 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF2076 PF09849.7 MSTRG.15657.1_2 - 3.1 7.6 9.5 5.1 6.9 9.5 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) zf-RING_2 PF13639.4 MSTRG.15657.1_3 - 1.8e-06 27.9 10.6 5.2e-06 26.5 6.8 3.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.3 MSTRG.15657.1_3 - 6.8e-05 22.4 4.0 0.00021 20.8 4.0 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-H2C2_2 PF13465.4 MSTRG.21196.1_1 - 3.2e-75 245.3 114.1 8.5e-10 38.5 0.7 17.6 17 0 0 17 17 17 13 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.21196.1_1 - 9.3e-58 189.5 130.7 3e-06 27.3 1.2 17.5 17 0 0 17 17 17 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.21196.1_1 - 7.1e-47 153.9 125.2 0.00039 20.9 0.5 17.3 17 0 0 17 17 17 15 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.21196.1_1 - 3.2e-31 106.8 75.2 0.0012 19.0 0.1 16.5 17 0 0 17 17 17 9 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 MSTRG.21196.1_1 - 1.5e-17 62.9 100.3 0.0021 17.9 1.8 17.2 17 0 0 17 17 17 7 C2H2-type zinc finger zf-met PF12874.5 MSTRG.21196.1_1 - 1.8e-13 50.2 101.6 0.002 18.3 0.2 16.2 16 0 0 16 16 16 7 Zinc-finger of C2H2 type zf-Di19 PF05605.10 MSTRG.21196.1_1 - 5.2e-07 29.7 65.7 0.027 14.6 3.2 8.8 7 1 0 7 7 7 5 Drought induced 19 protein (Di19), zinc-binding ADK_lid PF05191.12 MSTRG.21196.1_1 - 9e-05 22.3 40.8 0.064 13.2 0.5 9.5 7 2 2 9 9 9 3 Adenylate kinase, active site lid C1_4 PF07975.10 MSTRG.21196.1_1 - 0.00073 19.6 60.0 0.29 11.3 0.8 9.8 8 2 3 11 11 11 5 TFIIH C1-like domain zf-C2HC_2 PF13913.4 MSTRG.21196.1_1 - 0.002 17.9 2.6 0.002 17.9 2.6 13.3 14 0 0 14 14 14 3 zinc-finger of a C2HC-type Cnn_1N PF07989.9 MSTRG.21196.1_1 - 0.013 15.5 2.0 0.036 14.1 2.0 1.7 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 GAGA PF09237.9 MSTRG.21196.1_1 - 0.037 13.7 0.3 0.037 13.7 0.3 8.5 4 3 6 10 10 10 0 GAGA factor Ta0938 PF11494.6 MSTRG.21196.1_1 - 0.047 13.8 19.9 0.26 11.4 0.3 5.9 2 2 3 5 5 5 0 Ta0938 Baculo_IE-1 PF05290.9 MSTRG.21196.1_1 - 0.096 12.5 0.1 0.096 12.5 0.1 6.1 3 2 2 6 6 6 0 Baculovirus immediate-early protein (IE-0) DUF2360 PF10152.7 MSTRG.21196.1_1 - 0.27 11.5 2.0 0.53 10.5 2.0 1.5 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) bZIP_1 PF00170.19 MSTRG.21196.1_1 - 0.29 11.1 3.8 0.5 10.4 1.1 2.4 1 1 1 2 2 2 0 bZIP transcription factor HypA PF01155.17 MSTRG.21196.1_1 - 0.37 10.7 54.4 1.1 9.2 0.1 9.5 3 2 6 9 9 9 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.3 MSTRG.21196.1_1 - 1.2 9.8 58.7 0.57 10.8 1.1 8.7 3 2 8 11 11 11 0 zinc-ribbon family HELP PF03451.12 MSTRG.26270.5_1 - 1.6e-26 91.8 0.2 3e-13 49.3 0.1 2.6 2 0 0 2 2 2 2 HELP motif WD40 PF00400.30 MSTRG.26270.5_2 - 4.4e-22 77.8 25.1 0.00039 21.0 0.5 8.2 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.26270.5_2 - 3.7e-05 23.8 0.1 4.5 7.5 0.0 4.7 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.4 MSTRG.26270.5_2 - 0.02 14.4 0.0 0.038 13.4 0.0 1.4 1 0 0 1 1 1 0 PQQ-like domain CRAM_rpt PF07016.9 MSTRG.14691.1_1 - 0.1 12.3 22.7 2.7 7.7 0.8 8.1 8 2 0 8 8 8 0 Cysteine-rich acidic integral membrane protein precursor CobW_C PF07683.12 MSTRG.14691.1_3 - 0.18 11.6 1.2 47 3.9 0.0 4.3 4 2 0 4 4 4 0 Cobalamin synthesis protein cobW C-terminal domain PI-PLC-X PF00388.17 MSTRG.6560.2_3 - 2.4e-63 211.9 0.0 4e-63 211.2 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain SH2 PF00017.22 MSTRG.6560.2_3 - 2.6e-43 145.8 0.1 2.5e-22 78.6 0.0 2.7 2 0 0 2 2 2 2 SH2 domain PI-PLC-Y PF00387.17 MSTRG.6560.2_3 - 3e-38 130.6 0.0 7.7e-38 129.3 0.0 1.8 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 PF00018.26 MSTRG.6560.2_3 - 6.9e-15 54.3 0.4 1.7e-14 53.0 0.4 1.7 1 0 0 1 1 1 1 SH3 domain PH PF00169.27 MSTRG.6560.2_3 - 1.2e-14 54.5 0.2 7.2e-05 23.1 0.0 3.7 3 0 0 3 3 3 3 PH domain C2 PF00168.28 MSTRG.6560.2_3 - 3.7e-11 43.1 0.0 7.4e-11 42.1 0.0 1.5 1 0 0 1 1 1 1 C2 domain SH3_9 PF14604.4 MSTRG.6560.2_3 - 9.6e-10 38.0 0.1 2.1e-09 37.0 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH_12 PF16457.3 MSTRG.6560.2_3 - 3.4e-06 27.5 0.5 0.00032 21.1 0.0 3.5 4 0 0 4 4 4 1 Pleckstrin homology domain SH3_2 PF07653.15 MSTRG.6560.2_3 - 7.9e-06 25.3 0.0 2e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain GDPD PF03009.15 MSTRG.6560.2_3 - 0.016 14.8 0.0 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family PNISR PF15996.3 MSTRG.24586.3_1 - 1.3e-44 152.7 20.6 1.3e-44 152.7 20.6 5.6 2 2 2 4 4 4 1 Arginine/serine-rich protein PNISR Ank_4 PF13637.4 MSTRG.26141.2_2 - 3.9e-22 78.2 1.3 6e-11 42.5 0.1 4.1 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.5 MSTRG.26141.2_2 - 1.6e-20 73.3 0.0 8.6e-11 42.2 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 MSTRG.26141.2_2 - 1.7e-20 72.3 1.3 1.8e-05 24.8 0.0 4.4 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.4 MSTRG.26141.2_2 - 8.4e-20 70.4 3.7 2.3e-08 34.0 0.2 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.26141.2_2 - 1.1e-17 62.1 0.6 0.00012 22.1 0.0 4.6 5 0 0 5 5 5 3 Ankyrin repeat CGI-121 PF08617.8 MSTRG.11724.1_2 - 4.3e-43 147.1 0.8 5.4e-43 146.8 0.8 1.1 1 0 0 1 1 1 1 Kinase binding protein CGI-121 CTF_NFI PF00859.16 MSTRG.28862.1_3 - 3.1e-34 119.1 13.8 3.6e-34 118.9 13.8 1.1 1 0 0 1 1 1 1 CTF/NF-I family transcription modulation region DUF3682 PF12446.6 MSTRG.28862.1_3 - 5 7.5 7.5 6.1 7.2 7.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3682) GRAM PF02893.18 MSTRG.11719.1_3 - 6.8e-20 70.9 0.0 2.7e-19 69.0 0.0 1.9 2 0 0 2 2 2 1 GRAM domain PRT_C PF08372.8 MSTRG.11719.1_3 - 4.6e-05 23.1 0.6 0.00013 21.6 0.0 2.0 2 0 0 2 2 2 1 Plant phosphoribosyltransferase C-terminal DUF639 PF04842.10 MSTRG.11719.1_3 - 0.087 12.1 0.2 0.15 11.3 0.2 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) Ion_trans PF00520.29 MSTRG.27420.1_1 - 0.0013 17.8 0.0 0.0018 17.4 0.0 1.2 1 0 0 1 1 1 1 Ion transport protein Urb2 PF10441.7 MSTRG.27420.1_1 - 0.057 13.2 0.2 0.072 12.9 0.2 1.1 1 0 0 1 1 1 0 Urb2/Npa2 family IQ PF00612.25 MSTRG.1034.2_2 - 0.012 15.2 4.5 0.12 12.1 0.6 3.0 3 0 0 3 3 3 0 IQ calmodulin-binding motif DUF3915 PF13054.4 MSTRG.26382.1_1 - 0.069 13.0 7.4 0.084 12.7 7.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 MSTRG.26382.1_1 - 0.36 8.9 9.9 0.37 8.9 9.9 1.0 1 0 0 1 1 1 0 Atrophin-1 family Atrophin-1 PF03154.13 MSTRG.26382.1_2 - 5.6 5.0 6.2 5.8 4.9 6.2 1.0 1 0 0 1 1 1 0 Atrophin-1 family Atrophin-1 PF03154.13 MSTRG.26382.1_3 - 1.3 7.1 7.9 1.3 7.1 7.9 1.0 1 0 0 1 1 1 0 Atrophin-1 family Ribonuclease_T2 PF00445.16 MSTRG.23192.1_3 - 2.1e-54 184.4 2.1 3e-54 183.9 2.1 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family DUF4140 PF13600.4 MSTRG.6239.1_2 - 6.1 7.2 7.5 15 6.0 2.0 3.2 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DMAP_binding PF06464.9 MSTRG.14919.1_1 - 3.5e-33 114.6 1.3 8.9e-33 113.3 1.3 1.7 1 0 0 1 1 1 1 DMAP1-binding Domain AMP-binding PF00501.26 MSTRG.14919.1_1 - 9.9e-16 57.2 0.0 1.4e-15 56.7 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme GvpG PF05120.10 MSTRG.14919.1_1 - 0.00017 21.4 0.0 0.00036 20.3 0.0 1.4 1 0 0 1 1 1 1 Gas vesicle protein G DUF515 PF04415.10 MSTRG.14919.1_1 - 2.3 6.4 4.5 4.2 5.5 4.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Fanconi_A PF03511.12 MSTRG.14919.1_3 - 0.036 13.8 0.1 4.4 7.2 0.0 2.4 2 0 0 2 2 2 0 Fanconi anaemia group A protein PH PF00169.27 MSTRG.26783.1_3 - 0.00033 21.0 0.0 0.00082 19.7 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_10 PF15411.4 MSTRG.26783.1_3 - 0.015 15.4 0.3 0.04 14.0 0.3 1.7 1 1 0 1 1 1 0 Pleckstrin homology domain IQ_SEC7_PH PF16453.3 MSTRG.26783.1_3 - 0.037 13.9 0.0 0.066 13.1 0.0 1.3 1 0 0 1 1 1 0 PH domain RRM_3 PF08777.9 MSTRG.125.1_3 - 3.6e-28 97.5 1.9 3.6e-28 97.5 1.9 2.6 2 1 0 2 2 2 1 RNA binding motif La PF05383.15 MSTRG.125.1_3 - 1.3e-20 73.1 0.2 2.6e-20 72.1 0.2 1.6 1 0 0 1 1 1 1 La domain RRM_1 PF00076.20 MSTRG.125.1_3 - 2.2e-10 40.0 0.6 4.9e-07 29.3 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GRP PF07172.9 MSTRG.125.1_3 - 0.55 10.8 9.5 0.25 11.9 2.2 2.3 2 0 0 2 2 2 0 Glycine rich protein family FoP_duplication PF13865.4 MSTRG.125.1_3 - 5.4 7.5 23.8 4.4 7.8 1.6 2.3 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 ACC_central PF08326.10 MSTRG.26089.1_3 - 5.9e-280 930.4 6.7 7.3e-280 930.1 6.7 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.20 MSTRG.26089.1_3 - 5.5e-180 599.1 0.0 7.3e-180 598.7 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.15 MSTRG.26089.1_3 - 4.2e-52 176.6 0.0 8.6e-52 175.6 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.20 MSTRG.26089.1_3 - 7.6e-32 110.0 1.2 2.6e-31 108.3 0.0 2.4 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.17 MSTRG.26089.1_3 - 1e-22 80.1 0.0 5.7e-22 77.7 0.0 2.4 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.20 MSTRG.26089.1_3 - 2.5e-16 59.2 0.0 7e-16 57.7 0.0 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.4 MSTRG.26089.1_3 - 3.1e-08 32.6 0.0 0.0007 18.3 0.0 3.0 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.20 MSTRG.26089.1_3 - 2.3e-06 27.2 0.0 4.7e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.11 MSTRG.26089.1_3 - 2.5e-06 27.0 0.0 6e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.12 MSTRG.26089.1_3 - 0.00015 21.7 0.0 0.00034 20.6 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain Leuk-A4-hydro_C PF09127.9 MSTRG.26089.1_3 - 0.1 12.4 0.1 0.31 10.9 0.1 1.7 1 0 0 1 1 1 0 Leukotriene A4 hydrolase, C-terminal MetallophosN PF16371.3 MSTRG.26089.1_3 - 0.13 12.4 0.0 0.32 11.2 0.0 1.7 1 0 0 1 1 1 0 N terminal of Calcineurin-like phosphoesterase DUF2360 PF10152.7 MSTRG.10544.1_3 - 0.32 11.2 10.1 35 4.6 10.1 2.2 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) PH PF00169.27 MSTRG.22124.1_3 - 0.00047 20.5 0.2 0.00097 19.5 0.2 1.5 1 0 0 1 1 1 1 PH domain Prenyltransf PF01255.17 MSTRG.6832.3_2 - 9e-78 260.7 0.4 1.3e-77 260.2 0.4 1.2 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase RNA_pol_Rpb1_6 PF04992.12 MSTRG.6832.3_2 - 0.031 14.0 0.1 0.055 13.2 0.1 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 6 IQ PF00612.25 MSTRG.1658.2_1 - 0.0013 18.2 0.1 0.0033 16.9 0.1 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif PipA PF07108.9 MSTRG.1658.2_1 - 0.15 11.4 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 PipA protein DUF21 PF01595.18 MSTRG.27461.1_1 - 1.6e-05 24.6 0.0 2.4e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF21 zf-H2C2_2 PF13465.4 MSTRG.7152.1_3 - 1.2e-31 107.6 30.6 6e-08 32.7 1.2 5.1 5 0 0 5 5 5 5 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.7152.1_3 - 4.3e-16 58.2 47.9 2.8e-05 24.2 2.6 6.0 6 0 0 6 6 6 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.7152.1_3 - 2.4e-15 55.8 43.4 1.8e-05 25.1 1.8 6.1 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.7152.1_3 - 1.9e-10 40.3 32.0 4.4e-07 29.6 0.9 6.4 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.7152.1_3 - 2.8e-06 27.3 3.3 2e-05 24.6 0.4 6.0 6 1 0 6 6 5 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.7152.1_3 - 6e-06 26.3 1.1 6e-06 26.3 1.1 6.4 6 1 0 6 6 6 3 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.3 MSTRG.7152.1_3 - 0.00022 21.3 13.6 0.019 15.1 3.6 2.4 1 1 1 2 2 2 2 C2H2-type zinc ribbon zf-C2H2_11 PF16622.3 MSTRG.7152.1_3 - 0.0036 16.9 1.4 0.0036 16.9 1.4 5.7 6 0 0 6 6 6 3 zinc-finger C2H2-type HypA PF01155.17 MSTRG.7152.1_3 - 0.035 14.0 9.8 1.1 9.2 1.1 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-AN1 PF01428.14 MSTRG.7152.1_3 - 0.053 13.6 0.8 0.053 13.6 0.8 5.0 3 2 2 5 5 5 0 AN1-like Zinc finger zinc_ribbon_15 PF17032.3 MSTRG.7152.1_3 - 0.1 13.2 13.9 0.36 11.5 1.2 2.9 1 1 3 4 4 4 0 zinc-ribbon family DNA_RNApol_7kD PF03604.11 MSTRG.7152.1_3 - 0.67 9.5 0.1 0.67 9.5 0.1 4.4 5 0 0 5 5 5 0 DNA directed RNA polymerase, 7 kDa subunit zf-C2H2_2 PF12756.5 MSTRG.7152.1_3 - 0.97 9.7 25.4 1.2 9.3 1.0 4.7 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) Fer4_10 PF13237.4 MSTRG.7152.1_3 - 6.1 6.9 15.9 0.45 10.5 0.6 3.7 3 1 0 3 3 3 0 4Fe-4S dicluster domain zf-BED PF02892.13 MSTRG.7152.1_3 - 6.6 6.7 25.8 3.3 7.7 2.8 4.5 1 1 3 4 4 4 0 BED zinc finger zf-C2HE PF16278.3 MSTRG.7152.1_3 - 9.2 6.7 28.0 0.27 11.6 1.5 4.7 1 1 5 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger zf-CCHC_2 PF13696.4 MSTRG.7152.1_3 - 9.8 6.0 19.8 27 4.5 0.3 5.4 5 0 0 5 5 5 0 Zinc knuckle MAM PF00629.21 MSTRG.29054.1_3 - 5.3e-09 36.0 0.1 7.1e-09 35.6 0.1 1.2 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu Snf7 PF03357.19 MSTRG.7541.2_2 - 1.9e-36 125.1 14.5 1.9e-36 125.1 14.5 1.3 2 0 0 2 2 2 1 Snf7 MBOAT PF03062.17 MSTRG.23539.1_2 - 1.1e-50 172.8 35.4 1.8e-50 172.1 35.4 1.4 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family DUF1104 PF06518.9 MSTRG.23539.1_2 - 0.11 12.8 0.2 0.18 12.1 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1104) MBOAT_2 PF13813.4 MSTRG.23539.1_2 - 0.97 9.6 12.2 0.28 11.3 7.5 2.4 2 0 0 2 2 2 0 Membrane bound O-acyl transferase family DUF2207 PF09972.7 MSTRG.23539.1_2 - 2 7.0 0.0 2 7.0 0.0 2.9 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) SET PF00856.26 MSTRG.2129.1_1 - 1.1e-15 58.3 0.7 2e-15 57.4 0.1 1.8 2 1 0 2 2 2 1 SET domain TPR_12 PF13424.4 MSTRG.2129.1_1 - 1.5e-08 34.7 0.2 3.5e-05 23.9 0.0 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat zf-MYND PF01753.16 MSTRG.2129.1_1 - 3.1e-08 33.4 17.0 3.1e-08 33.4 17.0 2.4 2 0 0 2 2 2 1 MYND finger TPR_10 PF13374.4 MSTRG.2129.1_1 - 0.00048 19.8 0.2 0.62 9.9 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_3 PF07720.10 MSTRG.2129.1_1 - 0.029 14.2 0.1 0.076 12.9 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Rubis-subs-bind PF09273.9 MSTRG.2129.1_1 - 0.036 14.6 1.4 0.11 13.0 1.4 1.8 1 0 0 1 1 1 0 Rubisco LSMT substrate-binding DDHD PF02862.15 MSTRG.16846.2_1 - 1.3e-13 51.5 0.0 2.2e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 DDHD domain LNS2 PF08235.11 MSTRG.16846.2_1 - 0.016 14.5 0.1 0.086 12.2 0.1 1.9 1 1 0 1 1 1 0 LNS2 (Lipin/Ned1/Smp2) Acid_phosphat_B PF03767.12 MSTRG.16846.2_1 - 0.068 12.6 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) IP_trans PF02121.16 MSTRG.16846.2_2 - 8.9e-115 382.3 0.5 1.2e-114 381.9 0.5 1.2 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein DDHD PF02862.15 MSTRG.16846.2_2 - 1.7e-34 119.9 0.0 1.7e-34 119.9 0.0 1.8 3 0 0 3 3 3 1 DDHD domain LURAP PF14854.4 MSTRG.16846.2_2 - 1.8 8.4 4.0 1.3 8.9 0.2 2.4 2 0 0 2 2 2 0 Leucine rich adaptor protein Methyltransf_12 PF08242.10 MSTRG.25388.1_1 - 1.9e-08 34.8 0.0 5.1e-08 33.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 MSTRG.25388.1_1 - 4.5e-08 33.6 0.0 1.2e-07 32.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 MSTRG.25388.1_1 - 1.4e-06 28.7 0.0 3.1e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 MSTRG.25388.1_1 - 1.5e-06 28.1 0.2 4.3e-05 23.4 0.0 2.2 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.4 MSTRG.25388.1_1 - 0.003 17.2 0.0 0.0056 16.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.16 MSTRG.25388.1_1 - 0.17 11.1 0.0 0.25 10.5 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family ALS2CR8 PF15299.4 MSTRG.20586.1_3 - 4.4e-33 114.9 1.5 4.4e-33 114.9 1.5 1.8 2 0 0 2 2 2 1 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 CYTL1 PF15153.4 MSTRG.13766.1_3 - 9e-54 180.7 5.9 1.3e-53 180.1 5.9 1.2 1 0 0 1 1 1 1 Cytokine-like protein 1 Phosphorylase PF00343.18 MSTRG.8934.2_1 - 9e-225 748.0 0.0 1.2e-224 747.7 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase Insulin PF00049.16 MSTRG.20733.1_3 - 5.4 7.9 10.9 0.26 12.2 2.4 2.3 1 1 1 2 2 2 0 Insulin/IGF/Relaxin family Ion_trans_2 PF07885.14 MSTRG.4873.1_3 - 1e-34 118.2 12.3 5.5e-18 64.6 0.5 2.8 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.29 MSTRG.4873.1_3 - 3.7e-07 29.5 3.5 0.00069 18.8 0.5 2.2 1 1 1 2 2 2 2 Ion transport protein ABC2_membrane PF01061.22 MSTRG.4873.1_3 - 0.0031 16.8 6.1 0.0076 15.5 6.1 1.6 1 0 0 1 1 1 1 ABC-2 type transporter Globin PF00042.20 MSTRG.5252.1_1 - 1.1e-22 80.5 0.0 1.6e-22 80.0 0.0 1.2 1 0 0 1 1 1 1 Globin AA_permease_2 PF13520.4 MSTRG.9502.2_2 - 1.1e-51 175.9 23.6 1.1e-51 175.9 23.6 3.4 4 0 0 4 4 4 1 Amino acid permease AA_permease PF00324.19 MSTRG.9502.2_2 - 1.7e-39 135.6 23.3 1.7e-39 135.6 23.3 3.0 3 0 0 3 3 3 1 Amino acid permease AA_permease_C PF13906.4 MSTRG.9502.2_2 - 9.7e-25 86.3 6.3 9.7e-25 86.3 6.3 4.1 3 0 0 3 3 3 1 C-terminus of AA_permease Z1 PF10593.7 MSTRG.19178.1_1 - 0.11 11.9 0.0 0.14 11.5 0.0 1.1 1 0 0 1 1 1 0 Z1 domain Pkinase_Tyr PF07714.15 MSTRG.13082.2_1 - 1.4e-90 302.9 0.0 2e-90 302.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Sema PF01403.17 MSTRG.13082.2_1 - 3.1e-44 151.3 1.0 5.3e-44 150.5 1.0 1.2 1 0 0 1 1 1 1 Sema domain Pkinase PF00069.23 MSTRG.13082.2_1 - 4.8e-37 127.6 0.0 7e-37 127.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain TIG PF01833.22 MSTRG.13082.2_1 - 6.2e-16 58.1 0.2 3.8e-07 29.9 0.0 2.5 2 0 0 2 2 2 2 IPT/TIG domain Kinase-like PF14531.4 MSTRG.13082.2_1 - 0.0021 17.3 0.0 0.0034 16.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like zf-C2H2 PF00096.24 MSTRG.1003.1_1 - 6.2e-13 48.3 25.3 0.00022 21.3 1.0 4.3 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.1003.1_1 - 5.2e-08 32.9 10.9 5.9e-05 23.2 3.9 4.0 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.1003.1_1 - 0.0055 17.3 29.5 0.23 12.2 0.7 4.4 4 0 0 4 4 4 3 C2H2-type zinc finger FOXP-CC PF16159.3 MSTRG.1003.1_1 - 0.056 13.9 5.3 1.6 9.3 0.1 2.6 1 1 1 2 2 2 0 FOXP coiled-coil domain 7tm_2 PF00002.22 MSTRG.15604.1_3 - 1.7e-37 128.9 11.4 1.7e-37 128.9 11.4 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 MSTRG.15604.1_3 - 1.2e-23 83.0 2.7 2.3e-23 82.1 2.7 1.5 1 0 0 1 1 1 1 Hormone receptor domain DUF3915 PF13054.4 MSTRG.19115.1_1 - 0.6 10.0 3.4 1 9.2 3.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 MSTRG.19115.1_1 - 2 6.5 5.9 2.5 6.1 5.9 1.0 1 0 0 1 1 1 0 Atrophin-1 family DUF1751 PF08551.8 MSTRG.3150.1_2 - 6.5e-29 100.3 2.5 1.6e-28 99.0 2.5 1.7 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.20 MSTRG.3150.1_2 - 0.023 14.5 10.8 0.048 13.5 10.8 1.5 1 0 0 1 1 1 0 Rhomboid family zf-3CxxC PF13695.4 MSTRG.7197.1_2 - 4.4e-08 33.3 19.2 7.1e-08 32.7 19.2 1.3 1 0 0 1 1 1 1 Zinc-binding domain zf-3CxxC_2 PF17180.2 MSTRG.7197.1_2 - 0.0016 19.0 23.9 0.0048 17.5 23.9 1.9 1 1 0 1 1 1 1 Zinc-binding domain E1-E2_ATPase PF00122.18 MSTRG.9304.1_2 - 3.7e-36 124.4 0.0 5.8e-36 123.7 0.0 1.3 1 0 0 1 1 1 1 E1-E2 ATPase P5-ATPase PF12409.6 MSTRG.9304.1_2 - 4e-27 94.7 0.2 6.8e-27 93.9 0.2 1.4 1 0 0 1 1 1 1 P5-type ATPase cation transporter Hydrolase PF00702.24 MSTRG.9304.1_2 - 7.3e-20 72.0 0.0 2.2e-12 47.6 0.0 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 MSTRG.9304.1_2 - 2e-08 33.6 0.0 3.8e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.4 MSTRG.9304.1_2 - 0.00014 21.7 0.0 0.00026 20.9 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Pro_isomerase PF00160.19 MSTRG.6304.1_2 - 2.9e-45 154.3 0.0 3.6e-45 153.9 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD EF-hand_7 PF13499.4 MSTRG.6909.1_3 - 4e-17 62.3 2.5 6.4e-08 32.8 0.1 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.30 MSTRG.6909.1_3 - 4.2e-14 50.8 0.3 1.3e-05 24.2 0.0 3.7 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.4 MSTRG.6909.1_3 - 2.2e-13 48.9 0.3 6.9e-05 22.4 0.1 3.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.4 MSTRG.6909.1_3 - 1.1e-10 40.9 0.0 3e-06 26.8 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.6909.1_3 - 2e-09 36.4 2.2 0.0022 17.3 0.1 3.8 4 0 0 4 4 4 3 EF hand EF-hand_4 PF12763.5 MSTRG.6909.1_3 - 6.4e-05 22.7 0.2 0.074 12.9 0.0 2.6 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 MSTRG.6909.1_3 - 0.0032 17.6 0.3 0.65 10.2 0.0 2.3 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.4 MSTRG.6909.1_3 - 0.058 13.1 0.1 0.3 10.9 0.0 2.2 2 0 0 2 2 2 0 EF hand Smg4_UPF3 PF03467.13 MSTRG.26549.1_2 - 2.3e-41 141.6 0.7 2.3e-41 141.6 0.7 1.5 1 1 1 2 2 2 1 Smg-4/UPF3 family RRM_1 PF00076.20 MSTRG.26549.1_2 - 0.0014 18.3 0.0 0.0063 16.2 0.0 2.1 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-H2C2_2 PF13465.4 MSTRG.14119.3_2 - 6.8e-47 155.8 44.7 2.7e-06 27.4 0.2 9.4 8 0 0 8 8 8 8 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.14119.3_2 - 1.8e-24 84.6 87.5 0.0012 19.1 2.5 10.5 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.14119.3_2 - 2e-09 37.4 101.5 0.043 14.5 1.5 11.3 12 0 0 12 12 12 9 C2H2-type zinc finger NUDIX PF00293.26 MSTRG.6428.2_2 - 2.3e-09 37.2 0.0 3.9e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Anti-TRAP PF15777.3 MSTRG.12299.1_2 - 0.12 12.2 3.0 7.5 6.5 0.2 2.3 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein BIRC6 PF12356.6 MSTRG.12299.1_2 - 4.3 6.6 9.1 2.1 7.6 2.0 2.0 1 1 1 2 2 2 0 Baculoviral IAP repeat-containing protein 6 zf-C2H2 PF00096.24 MSTRG.17705.2_1 - 6e-17 61.0 24.2 2.9e-05 24.1 0.4 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.17705.2_1 - 5.1e-14 51.9 26.3 3.6e-07 30.2 0.2 4.9 6 0 0 6 6 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.17705.2_1 - 2.3e-11 43.4 20.5 0.028 15.1 0.2 4.6 4 0 0 4 4 4 4 C2H2-type zinc finger Transpos_assoc PF13963.4 MSTRG.17705.2_1 - 0.0018 18.6 3.1 0.1 13.0 0.2 2.7 2 1 0 2 2 2 1 Transposase-associated domain IBR PF01485.19 MSTRG.17705.2_1 - 0.028 14.5 1.1 0.028 14.5 1.1 2.5 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-C2H2_aberr PF17017.3 MSTRG.17705.2_1 - 0.034 14.2 6.7 5.1 7.1 0.1 3.3 1 1 1 3 3 3 0 Aberrant zinc-finger Raffinose_syn PF05691.10 MSTRG.17705.2_1 - 0.036 11.7 0.0 0.057 11.1 0.0 1.2 1 0 0 1 1 1 0 Raffinose synthase or seed imbibition protein Sip1 zf-TRAF PF02176.16 MSTRG.17705.2_1 - 0.16 12.6 11.7 7.7 7.2 2.5 3.4 1 1 2 3 3 3 0 TRAF-type zinc finger CHORD PF04968.10 MSTRG.17705.2_1 - 0.16 12.5 11.6 16 6.2 2.1 4.3 3 2 1 4 4 4 0 CHORD CCAP PF11105.6 MSTRG.17705.2_1 - 0.23 11.3 4.5 1.5 8.6 0.8 2.5 1 1 1 2 2 2 0 Arthropod cardioacceleratory peptide 2a zf-C2H2_jaz PF12171.6 MSTRG.17705.2_1 - 0.36 11.1 9.8 13 6.1 0.4 3.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_9 PF14369.4 MSTRG.17705.2_1 - 0.81 9.9 4.0 3 8.0 0.1 3.1 3 0 0 3 3 3 0 zinc-ribbon zf-C2H2_11 PF16622.3 MSTRG.17705.2_1 - 1.1 8.9 6.9 5 6.8 0.4 3.0 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-CGNR PF11706.6 MSTRG.17705.2_1 - 1.2 8.9 6.9 7.6 6.3 0.4 3.0 3 1 0 3 3 2 0 CGNR zinc finger zf-met PF12874.5 MSTRG.17705.2_1 - 1.7 9.0 5.1 5.4 7.4 0.1 3.2 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Crystall PF00030.17 MSTRG.19609.3_2 - 2.1e-08 34.1 0.0 3.1e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Beta/Gamma crystallin Polyhedrin PF00738.16 MSTRG.20781.1_1 - 0.042 13.0 0.0 0.051 12.8 0.0 1.0 1 0 0 1 1 1 0 Polyhedrin RRM_1 PF00076.20 MSTRG.11413.8_2 - 1.9e-12 46.7 0.0 5.7e-12 45.2 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 MSTRG.11413.8_2 - 0.0035 16.8 0.0 0.0059 16.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.6 MSTRG.11413.8_2 - 0.0039 17.1 0.0 0.0088 16.0 0.0 1.6 1 0 0 1 1 1 1 Limkain b1 RRM_1 PF00076.20 MSTRG.11413.8_3 - 7.4e-16 57.6 0.0 4.1e-15 55.2 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.11413.8_3 - 0.00018 21.4 0.1 0.068 13.2 0.1 2.6 2 1 0 2 2 2 2 RNA recognition motif OPA3 PF07047.10 MSTRG.27148.4_1 - 2.3e-43 146.8 0.0 3e-43 146.4 0.0 1.1 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) SlyX PF04102.10 MSTRG.27148.4_1 - 0.068 13.7 0.6 0.12 12.9 0.6 1.3 1 0 0 1 1 1 0 SlyX TMF_DNA_bd PF12329.6 MSTRG.27148.4_1 - 0.16 11.9 0.2 0.27 11.1 0.2 1.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Cytochrom_B561 PF03188.14 MSTRG.16512.1_1 - 3.3e-42 143.7 4.9 3.3e-42 143.7 4.9 1.9 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 COX1 PF00115.18 MSTRG.16512.1_1 - 0.002 16.9 11.2 0.0029 16.4 11.2 1.3 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I DUF4405 PF14358.4 MSTRG.16512.1_1 - 0.024 15.0 0.9 0.024 15.0 0.9 3.2 3 1 2 5 5 5 0 Domain of unknown function (DUF4405) DUF1129 PF06570.9 MSTRG.16512.1_1 - 0.03 13.7 2.1 0.089 12.2 1.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) DUF4079 PF13301.4 MSTRG.16512.1_1 - 0.87 9.6 10.7 16 5.5 9.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) TMEM119 PF15724.3 MSTRG.5359.2_2 - 0.034 14.1 0.3 0.061 13.2 0.3 1.3 1 0 0 1 1 1 0 TMEM119 family Iwr1 PF08574.8 MSTRG.5359.2_3 - 6e-09 36.7 14.0 6e-09 36.7 14.0 3.4 2 2 1 3 3 3 1 Transcription factor Iwr1 S-antigen PF05756.9 MSTRG.5359.2_3 - 2.5 8.3 5.3 6 7.0 5.3 1.6 1 0 0 1 1 1 0 S-antigen protein DNA_pol_phi PF04931.11 MSTRG.5359.2_3 - 5.5 4.8 10.1 9.1 4.1 10.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi DotU PF09850.7 MSTRG.21383.1_1 - 0.0083 15.8 0.1 0.0091 15.7 0.1 1.1 1 0 0 1 1 1 1 Type VI secretion system protein DotU ILEI PF15711.3 MSTRG.16923.1_1 - 6.5e-32 109.7 0.0 2.4e-20 72.6 0.0 2.9 3 0 0 3 3 3 2 Interleukin-like EMT inducer G8 PF10162.7 MSTRG.16923.1_1 - 1.5e-22 79.9 0.0 4e-22 78.5 0.0 1.7 2 0 0 2 2 2 1 G8 domain Lar_restr_allev PF14354.4 MSTRG.16923.1_1 - 0.17 12.2 1.5 2 8.7 0.0 2.6 2 0 0 2 2 2 0 Restriction alleviation protein Lar Nup54 PF13874.4 MSTRG.19637.2_3 - 1.1e-44 151.7 3.3 1.1e-44 151.7 3.3 1.7 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 Nucleoporin_FG2 PF15967.3 MSTRG.19637.2_3 - 5.6 5.2 43.1 11 4.3 43.1 1.5 1 0 0 1 1 1 0 Nucleoporin FG repeated region Arrestin_C PF02752.20 MSTRG.5718.2_1 - 9.7e-07 29.1 0.4 1.7e-06 28.3 0.4 1.4 1 1 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Rgp1 PF08737.8 MSTRG.5718.2_1 - 0.35 9.8 0.8 2.6 7.0 0.3 1.9 2 0 0 2 2 2 0 Rgp1 ABC_membrane PF00664.21 MSTRG.4065.1_2 - 6.9e-20 71.7 4.9 8.4e-20 71.4 4.9 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.25 MSTRG.4065.1_2 - 9.3e-20 71.4 0.0 1.6e-19 70.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.17 MSTRG.4065.1_2 - 3.7e-05 23.1 0.4 0.1 11.9 0.1 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.4 MSTRG.4065.1_2 - 0.00059 19.6 0.1 0.068 12.8 0.2 2.2 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.4 MSTRG.4065.1_2 - 0.0012 19.1 0.0 0.0026 18.0 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.14 MSTRG.4065.1_2 - 0.007 16.1 0.1 0.012 15.4 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Pox_I5 PF04713.10 MSTRG.4065.1_2 - 0.0084 16.0 0.8 0.11 12.4 0.0 2.5 2 0 0 2 2 2 1 Poxvirus protein I5 AAA_29 PF13555.4 MSTRG.4065.1_2 - 0.015 14.8 0.1 0.037 13.6 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.4 MSTRG.4065.1_2 - 0.024 15.0 0.0 0.042 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.23 MSTRG.4065.1_2 - 0.026 14.0 0.0 0.041 13.4 0.0 1.2 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Zeta_toxin PF06414.10 MSTRG.4065.1_2 - 0.027 13.7 0.1 0.067 12.3 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin AAA_15 PF13175.4 MSTRG.4065.1_2 - 0.031 13.8 0.3 0.043 13.3 0.3 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 MSTRG.4065.1_2 - 0.061 13.5 0.2 0.13 12.4 0.2 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.4 MSTRG.4065.1_2 - 0.081 13.0 0.0 0.2 11.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain NACHT PF05729.10 MSTRG.4065.1_2 - 0.13 12.0 0.3 0.23 11.2 0.3 1.4 1 0 0 1 1 1 0 NACHT domain ATPase_2 PF01637.16 MSTRG.4065.1_2 - 0.14 12.0 0.0 0.23 11.2 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Dynamin_N PF00350.21 MSTRG.4065.1_2 - 0.15 12.0 0.2 0.28 11.1 0.2 1.4 1 0 0 1 1 1 0 Dynamin family DUF2101 PF09874.7 MSTRG.4065.1_2 - 0.38 10.3 4.5 0.14 11.8 0.2 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2101) Peptidase_M41 PF01434.16 MSTRG.19219.1_1 - 1.2e-71 240.6 0.7 2e-71 239.9 0.7 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.27 MSTRG.19219.1_1 - 7.5e-42 142.8 0.0 1.8e-41 141.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 MSTRG.19219.1_1 - 9.1e-05 22.8 0.0 0.0054 17.0 0.1 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.4 MSTRG.19219.1_1 - 0.00033 20.8 0.0 0.025 14.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.11 MSTRG.19219.1_1 - 0.00051 19.0 0.0 0.0012 17.8 0.0 1.5 1 0 0 1 1 1 1 TIP49 C-terminus RuvB_N PF05496.10 MSTRG.19219.1_1 - 0.00064 18.9 0.0 0.0012 18.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.12 MSTRG.19219.1_1 - 0.00093 19.1 0.0 0.003 17.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.15 MSTRG.19219.1_1 - 0.0055 16.3 0.0 0.024 14.3 0.0 2.0 2 0 0 2 2 2 1 IstB-like ATP binding protein Mg_chelatase PF01078.19 MSTRG.19219.1_1 - 0.018 14.3 0.3 0.049 12.9 0.3 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_2 PF07724.12 MSTRG.19219.1_1 - 0.02 14.9 0.0 0.046 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_33 PF13671.4 MSTRG.19219.1_1 - 0.026 14.6 0.0 0.053 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.11 MSTRG.19219.1_1 - 0.036 13.1 0.0 0.11 11.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_18 PF13238.4 MSTRG.19219.1_1 - 0.062 13.7 0.0 0.17 12.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.4 MSTRG.19219.1_1 - 0.13 11.7 0.3 1.2 8.6 0.3 2.1 1 1 1 2 2 2 0 AAA domain Glyco_hydro_47 PF01532.18 MSTRG.18727.2_3 - 4.4e-166 553.2 0.0 5.3e-166 552.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_88 PF07470.11 MSTRG.18727.2_3 - 0.00068 18.7 0.0 0.21 10.5 0.0 2.1 2 0 0 2 2 2 2 Glycosyl Hydrolase Family 88 Wzy_C_2 PF11846.6 MSTRG.18727.2_3 - 0.074 12.8 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Virulence factor membrane-bound polymerase, C-terminal L_HMGIC_fpl PF10242.7 MSTRG.1962.1_3 - 8e-61 205.3 8.2 1.3e-60 204.6 8.2 1.3 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein Claudin_2 PF13903.4 MSTRG.1962.1_3 - 0.0089 15.7 9.8 0.82 9.3 11.3 2.3 2 0 0 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction Ig_3 PF13927.4 MSTRG.20128.1_2 - 0.00046 20.6 0.8 1.6 9.2 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain IncA PF04156.12 MSTRG.20128.1_2 - 0.0043 16.7 0.2 0.027 14.1 0.0 2.0 2 0 0 2 2 2 1 IncA protein Shisa PF13908.4 MSTRG.20128.1_2 - 0.0052 16.9 2.8 0.083 13.0 0.1 2.2 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator EphA2_TM PF14575.4 MSTRG.20128.1_2 - 0.0055 17.4 0.0 0.16 12.7 0.0 2.5 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain Ig_2 PF13895.4 MSTRG.20128.1_2 - 0.0067 16.6 0.0 0.017 15.3 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain WBP-1 PF11669.6 MSTRG.20128.1_2 - 0.024 15.2 0.6 2.8 8.5 0.1 2.6 2 0 0 2 2 2 0 WW domain-binding protein 1 V-set PF07686.15 MSTRG.20128.1_2 - 0.049 13.7 0.1 0.23 11.5 0.0 2.1 2 0 0 2 2 2 0 Immunoglobulin V-set domain Protocadherin PF08374.9 MSTRG.20128.1_2 - 0.063 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Protocadherin Glycophorin_A PF01102.16 MSTRG.20128.1_2 - 0.064 13.4 0.1 0.15 12.2 0.1 1.6 1 0 0 1 1 1 0 Glycophorin A I-set PF07679.14 MSTRG.20128.1_2 - 0.13 12.2 4.2 0.45 10.5 0.6 2.8 3 1 0 3 3 3 0 Immunoglobulin I-set domain LST1 PF05083.11 MSTRG.20128.1_2 - 0.3 11.3 0.0 0.3 11.3 0.0 1.9 2 0 0 2 2 1 0 LST-1 protein Mit_proteolip PF08039.9 MSTRG.20093.1_1 - 4.4 7.6 19.5 9.1 6.6 4.5 2.3 1 1 1 2 2 2 0 Mitochondrial proteolipid Mit_proteolip PF08039.9 MSTRG.20093.1_2 - 0.48 10.6 11.8 0.23 11.6 8.8 2.0 1 1 1 2 2 2 0 Mitochondrial proteolipid Mit_proteolip PF08039.9 MSTRG.20093.1_3 - 1.6 9.0 15.9 0.33 11.2 8.5 2.3 1 1 1 2 2 2 0 Mitochondrial proteolipid FYVE PF01363.19 MSTRG.23738.3_1 - 3.6e-16 58.9 15.2 1.3e-15 57.1 15.2 2.0 1 0 0 1 1 1 1 FYVE zinc finger RUN PF02759.17 MSTRG.23738.3_1 - 4.8e-08 32.9 1.4 3.3e-07 30.2 0.0 3.1 2 0 0 2 2 2 1 RUN domain Spc7 PF08317.9 MSTRG.23738.3_1 - 0.002 16.9 21.5 0.002 16.9 21.5 8.2 1 1 7 8 8 8 2 Spc7 kinetochore protein Reo_sigmaC PF04582.10 MSTRG.23738.3_1 - 0.0033 16.7 55.6 0.0033 16.7 4.8 7.4 1 1 6 8 8 8 5 Reovirus sigma C capsid protein GOLD_2 PF13897.4 MSTRG.23738.3_3 - 4.8e-06 27.0 0.0 5.4e-05 23.6 0.0 2.0 1 1 0 1 1 1 1 Golgi-dynamics membrane-trafficking YAF2_RYBP PF17219.1 MSTRG.15204.1_3 - 2.8e-18 64.9 0.0 4.8e-18 64.2 0.0 1.4 1 0 0 1 1 1 1 Yaf2/RYBP C-terminal binding motif zf-RanBP PF00641.16 MSTRG.15204.1_3 - 5.3e-07 28.7 2.3 5.3e-07 28.7 2.3 2.0 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others C1_2 PF03107.14 MSTRG.15204.1_3 - 0.86 9.8 4.8 0.56 10.4 1.1 2.3 2 0 0 2 2 2 0 C1 domain PXA PF02194.13 MSTRG.16397.4_1 - 3.8e-32 111.3 0.1 5.9e-32 110.7 0.1 1.3 1 0 0 1 1 1 1 PXA domain RGS PF00615.17 MSTRG.16397.4_1 - 7.3e-12 45.5 0.0 1.1e-11 44.9 0.0 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain APC_u13 PF16634.3 MSTRG.16397.4_1 - 0.07 12.9 0.1 0.16 11.7 0.1 1.6 1 0 0 1 1 1 0 Unstructured region on APC between APC_crr and SAMP Nexin_C PF08628.10 MSTRG.16397.4_2 - 3e-16 59.9 0.0 5.3e-16 59.1 0.0 1.4 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.22 MSTRG.16397.4_3 - 2.2e-18 66.2 0.4 4.4e-18 65.2 0.4 1.5 1 0 0 1 1 1 1 PX domain RUN PF02759.17 MSTRG.20766.2_2 - 5.8e-24 84.4 0.1 3.2e-23 82.1 0.0 2.2 2 0 0 2 2 2 1 RUN domain MHC_I PF00129.16 MSTRG.16140.7_3 - 8e-20 71.0 0.1 1e-19 70.7 0.1 1.1 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 MSTRG.16140.7_3 - 1e-08 35.4 0.0 2.7e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 MSTRG.16140.7_3 - 0.01 16.3 0.0 0.038 14.5 0.0 2.0 2 0 0 2 2 2 0 Immunoglobulin domain Peptidase_Mx PF15887.3 MSTRG.16140.7_3 - 0.018 14.3 0.3 0.035 13.4 0.3 1.4 1 0 0 1 1 1 0 Putative zinc-binding metallo-peptidase SPICE PF15678.3 MSTRG.5564.3_1 - 2.3e-29 102.9 0.3 3.2e-29 102.4 0.3 1.1 1 0 0 1 1 1 1 Centriole duplication and mitotic chromosome congression SPICE PF15678.3 MSTRG.5564.3_2 - 3.8e-44 151.6 5.3 3.8e-44 151.6 5.3 1.8 2 0 0 2 2 2 1 Centriole duplication and mitotic chromosome congression ERM PF00769.17 MSTRG.5564.3_2 - 0.00014 21.7 4.4 0.00014 21.7 4.4 1.9 2 0 0 2 2 2 1 Ezrin/radixin/moesin family MSL1_dimer PF16801.3 MSTRG.5564.3_2 - 0.095 12.3 1.3 0.27 10.9 1.3 1.7 1 0 0 1 1 1 0 Dimerisation domain of Male-specific-Lethal 1 DUF812 PF05667.9 MSTRG.5564.3_2 - 0.33 9.7 7.0 0.34 9.6 2.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF812) IncA PF04156.12 MSTRG.5564.3_2 - 0.44 10.2 12.4 1.4 8.6 7.5 2.4 2 0 0 2 2 2 0 IncA protein Bap31 PF05529.10 MSTRG.5564.3_2 - 2.5 7.5 10.8 0.089 12.3 4.7 1.6 2 0 0 2 2 2 0 B-cell receptor-associated protein 31-like MA3 PF02847.15 MSTRG.2612.3_3 - 7e-29 100.0 0.1 1.5e-28 98.9 0.1 1.6 1 0 0 1 1 1 1 MA3 domain W2 PF02020.16 MSTRG.2612.3_3 - 2.8e-21 75.3 2.4 1.7e-19 69.6 0.4 2.5 2 0 0 2 2 2 2 eIF4-gamma/eIF5/eIF2-epsilon PCMT PF01135.17 MSTRG.20803.1_1 - 0.16 11.6 0.2 0.29 10.7 0.2 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RHD_DNA_bind PF00554.20 MSTRG.14632.1_3 - 2.5e-71 238.9 0.0 2.9e-71 238.7 0.0 1.1 1 0 0 1 1 1 1 Rel homology DNA-binding domain SNF PF00209.16 MSTRG.3854.1_2 - 1.8e-190 633.9 38.0 2.3e-190 633.6 38.0 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family ADK PF00406.20 MSTRG.10721.1_2 - 5.5e-43 146.5 0.0 8.1e-43 146.0 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.4 MSTRG.10721.1_2 - 3.1e-16 59.9 0.0 4.8e-16 59.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.12 MSTRG.10721.1_2 - 1.7e-13 50.2 0.0 3.8e-13 49.1 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.4 MSTRG.10721.1_2 - 1.8e-06 28.4 0.0 3.7e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.16 MSTRG.10721.1_2 - 1.2e-05 25.0 0.0 1.8e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Cytidylate kinase TGF_beta PF00019.18 MSTRG.15568.1_2 - 1.4e-12 48.2 0.8 2.4e-12 47.5 0.8 1.3 1 0 0 1 1 1 1 Transforming growth factor beta like domain Cys_knot PF00007.20 MSTRG.15568.1_2 - 0.058 13.6 0.8 0.11 12.6 0.8 1.6 1 1 0 1 1 1 0 Cystine-knot domain CDC45 PF02724.12 MSTRG.15568.1_2 - 0.11 10.7 3.7 0.14 10.3 3.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Sprouty PF05210.11 MSTRG.20841.1_2 - 3.1e-25 88.6 19.6 3.1e-25 88.6 19.6 2.5 2 0 0 2 2 2 1 Sprouty protein (Spry) DUF4528 PF15031.4 MSTRG.2790.1_1 - 0.25 11.3 1.8 0.34 10.8 1.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4528) DIM PF08194.10 MSTRG.23452.15_1 - 0.43 10.7 0.1 0.43 10.7 0.1 3.8 3 1 0 3 3 3 0 DIM protein PRIMA1 PF16101.3 MSTRG.23452.15_3 - 9.5 6.2 7.4 19 5.2 7.4 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 TPR_12 PF13424.4 MSTRG.25258.1_2 - 2.7e-24 85.1 16.4 4.9e-06 26.6 0.9 5.9 5 0 0 5 5 5 4 Tetratricopeptide repeat Ank_4 PF13637.4 MSTRG.25258.1_2 - 8.4e-24 83.5 2.2 5e-13 49.1 0.1 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 MSTRG.25258.1_2 - 7.3e-21 74.4 0.4 3.1e-14 53.2 0.0 3.4 3 1 1 4 4 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.25258.1_2 - 7.1e-20 70.7 1.9 6.8e-08 32.5 0.1 3.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.25258.1_2 - 6.5e-17 59.8 0.3 4.6e-07 29.5 0.1 4.0 3 0 0 3 3 3 3 Ankyrin repeat TPR_7 PF13176.4 MSTRG.25258.1_2 - 1.8e-15 55.6 12.2 0.0075 16.1 0.1 8.0 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.25258.1_2 - 2.3e-15 55.5 13.7 0.016 14.8 0.2 8.8 8 0 0 8 8 8 4 Tetratricopeptide repeat Ank PF00023.28 MSTRG.25258.1_2 - 2.5e-15 56.0 1.7 3.3e-06 27.2 0.1 4.4 4 0 0 4 4 3 2 Ankyrin repeat TPR_2 PF07719.15 MSTRG.25258.1_2 - 2e-13 49.2 13.1 0.079 13.0 0.1 8.5 8 0 0 8 8 8 4 Tetratricopeptide repeat LRR_6 PF13516.4 MSTRG.25258.1_2 - 3.4e-12 45.3 21.3 0.06 13.3 1.1 9.4 9 0 0 9 9 9 4 Leucine Rich repeat TPR_8 PF13181.4 MSTRG.25258.1_2 - 1.9e-11 43.1 6.0 0.066 13.3 0.0 7.8 8 0 0 8 8 8 2 Tetratricopeptide repeat LRR_4 PF12799.5 MSTRG.25258.1_2 - 1.8e-07 31.1 23.5 0.0008 19.6 0.1 6.1 5 2 1 6 6 6 2 Leucine Rich repeats (2 copies) RPN7 PF10602.7 MSTRG.25258.1_2 - 6.5e-05 22.5 3.4 0.047 13.2 0.1 3.5 2 2 1 3 3 3 2 26S proteasome subunit RPN7 TPR_14 PF13428.4 MSTRG.25258.1_2 - 0.0008 19.9 7.8 74 4.4 0.0 8.3 8 1 1 9 9 9 0 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.25258.1_2 - 0.0015 18.2 13.4 1.2 9.0 0.2 6.0 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.25258.1_2 - 0.004 17.3 1.3 3.5 8.1 0.1 4.9 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.25258.1_2 - 0.019 15.4 0.1 73 4.2 0.0 4.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.25258.1_2 - 0.11 12.0 7.7 11 5.7 0.0 6.0 8 0 0 8 8 7 0 TPR repeat LRR_8 PF13855.4 MSTRG.25258.1_2 - 3.4 7.4 24.9 0.45 10.2 1.8 5.9 4 2 2 6 6 5 0 Leucine rich repeat TPR_16 PF13432.4 MSTRG.25258.1_2 - 6.5 7.4 12.4 33 5.2 0.2 6.0 6 2 1 7 7 5 0 Tetratricopeptide repeat Asp PF00026.21 MSTRG.11847.1_3 - 6.1e-119 397.0 0.0 7.2e-119 396.7 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 MSTRG.11847.1_3 - 3.5e-10 40.3 0.3 1.6e-08 34.9 0.3 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 MSTRG.11847.1_3 - 3.6e-05 23.4 0.3 6.6e-05 22.5 0.3 1.4 1 0 0 1 1 1 1 A1 Propeptide TAXi_C PF14541.4 MSTRG.11847.1_3 - 8.8e-05 22.2 0.0 0.00044 19.9 0.0 2.0 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal Spectrin PF00435.19 MSTRG.3384.1_3 - 1.3e-05 25.5 0.0 1.4e-05 25.4 0.0 1.1 1 0 0 1 1 1 1 Spectrin repeat SNF PF00209.16 MSTRG.23143.1_2 - 8.3e-22 77.4 1.6 1.5e-21 76.6 1.6 1.4 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family ATP1G1_PLM_MAT8 PF02038.14 MSTRG.9087.1_1 - 1.1e-20 72.5 0.2 2e-20 71.7 0.2 1.4 1 0 0 1 1 1 1 ATP1G1/PLM/MAT8 family DUF2207 PF09972.7 MSTRG.9087.1_1 - 0.016 13.9 0.1 0.02 13.5 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Mitoc_L55 PF09776.7 MSTRG.24328.4_3 - 6.9e-42 141.7 0.9 9.4e-42 141.3 0.9 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L55 Parathyroid PF01279.15 MSTRG.29695.1_2 - 2.8e-44 150.0 0.3 3.5e-44 149.7 0.3 1.1 1 0 0 1 1 1 1 Parathyroid hormone family Ion_trans PF00520.29 MSTRG.5644.2_3 - 1.5e-52 178.2 61.4 2.7e-26 92.1 23.4 2.1 2 0 0 2 2 2 2 Ion transport protein Peripla_BP_5 PF13433.4 MSTRG.5644.2_3 - 0.054 12.3 2.2 0.083 11.7 2.2 1.1 1 0 0 1 1 1 0 Periplasmic binding protein domain Pkinase PF00069.23 MSTRG.12942.3_3 - 1.2e-71 241.1 0.0 1.5e-71 240.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.12942.3_3 - 2.1e-33 115.6 0.0 3e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.12942.3_3 - 3.7e-07 29.6 0.1 8.1e-07 28.5 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Lectin_C PF00059.19 MSTRG.16682.1_3 - 4.2e-19 69.1 0.2 6.5e-19 68.5 0.2 1.3 1 0 0 1 1 1 1 Lectin C-type domain Sushi PF00084.18 MSTRG.16682.1_3 - 7.2e-07 29.6 0.4 7.2e-07 29.6 0.4 2.6 3 0 0 3 3 3 1 Sushi repeat (SCR repeat) UL45 PF05473.10 MSTRG.16682.1_3 - 0.076 12.5 0.1 0.14 11.6 0.1 1.3 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Syntaxin_2 PF14523.4 MSTRG.2795.1_1 - 5.8e-24 84.2 14.9 1.3e-22 79.9 9.4 2.2 2 0 0 2 2 2 2 Syntaxin-like protein SNARE PF05739.17 MSTRG.2795.1_1 - 7.8e-18 64.1 2.6 7.8e-18 64.1 2.6 2.0 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.23 MSTRG.2795.1_1 - 9.2e-08 31.9 12.1 7.2e-07 28.9 12.1 2.3 1 1 0 1 1 1 1 Syntaxin DUF3040 PF11239.6 MSTRG.2795.1_1 - 0.018 15.2 0.1 0.042 14.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) DUF4407 PF14362.4 MSTRG.2795.1_1 - 0.4 9.8 6.7 0.35 10.0 2.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Prominin PF05478.9 MSTRG.2795.1_1 - 1 7.1 7.4 0.064 11.1 0.5 1.9 2 0 0 2 2 2 0 Prominin SlyX PF04102.10 MSTRG.2795.1_1 - 3.7 8.1 15.0 0.84 10.2 0.8 3.1 2 1 1 3 3 3 0 SlyX Synaptobrevin PF00957.19 MSTRG.2795.1_1 - 4.6 7.0 7.3 0.27 10.9 1.4 2.0 2 0 0 2 2 2 0 Synaptobrevin RUN PF02759.17 MSTRG.2503.1_2 - 1e-25 90.1 0.1 2.2e-25 89.0 0.0 1.6 2 0 0 2 2 2 1 RUN domain DUF3788 PF12663.5 MSTRG.2503.1_2 - 0.029 14.2 0.0 0.1 12.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3788) Phage_GP20 PF06810.9 MSTRG.2503.1_2 - 0.042 13.5 3.2 0.07 12.8 3.2 1.3 1 0 0 1 1 1 0 Phage minor structural protein GP20 IncA PF04156.12 MSTRG.2503.1_2 - 3.5 7.2 6.6 7.9 6.1 6.6 1.5 1 0 0 1 1 1 0 IncA protein IBV_3A PF03617.11 MSTRG.8795.2_3 - 0.002 18.0 7.8 2.6 8.0 0.3 3.4 3 0 0 3 3 3 3 IBV 3A protein F-box-like PF12937.5 MSTRG.12324.1_2 - 2.7e-05 23.8 5.4 0.00014 21.6 5.4 2.3 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 MSTRG.12324.1_2 - 5.5e-05 22.8 5.7 5.5e-05 22.8 5.7 2.3 3 0 0 3 3 3 1 F-box domain zf-LYAR PF08790.9 MSTRG.13706.1_2 - 1.5e-16 59.8 6.3 2.7e-15 55.8 1.7 2.6 2 0 0 2 2 2 2 LYAR-type C2HC zinc finger CDC27 PF09507.8 MSTRG.13706.1_2 - 0.048 12.9 25.4 0.061 12.6 25.4 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 IBR PF01485.19 MSTRG.13706.1_2 - 0.92 9.6 7.1 2.3 8.4 7.1 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain C1_4 PF07975.10 MSTRG.13706.1_2 - 1.4 9.1 6.8 6.6 7.0 6.7 2.1 1 1 1 2 2 2 0 TFIIH C1-like domain Trypsin_2 PF13365.4 MSTRG.3992.1_2 - 6.1e-23 82.2 1.9 1.1e-15 58.7 1.5 2.3 2 0 0 2 2 2 2 Trypsin-like peptidase domain Trypsin PF00089.24 MSTRG.3992.1_2 - 3.5e-07 30.1 0.5 3.5e-07 30.1 0.5 1.6 2 0 0 2 2 2 1 Trypsin Ig_3 PF13927.4 MSTRG.17165.1_3 - 6e-14 52.3 6.4 1.1e-05 25.8 0.1 4.7 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.17165.1_3 - 2.3e-12 46.9 7.5 3.7e-07 30.3 0.0 4.5 4 0 0 4 4 4 3 Immunoglobulin domain I-set PF07679.14 MSTRG.17165.1_3 - 3.8e-10 39.5 0.5 0.11 12.4 0.0 5.0 4 1 0 4 4 4 3 Immunoglobulin I-set domain V-set PF07686.15 MSTRG.17165.1_3 - 5.6e-10 39.2 0.1 3e-07 30.4 0.0 3.1 3 0 0 3 3 3 1 Immunoglobulin V-set domain ig PF00047.23 MSTRG.17165.1_3 - 1.1e-05 25.3 3.7 0.088 12.8 0.0 4.7 4 2 0 4 4 4 2 Immunoglobulin domain C2-set_2 PF08205.10 MSTRG.17165.1_3 - 0.00011 22.1 4.9 0.0034 17.3 1.8 3.2 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 MSTRG.17165.1_3 - 0.025 14.9 1.8 0.42 11.0 0.8 3.0 2 1 0 2 2 2 0 Immunoglobulin C1-set domain RAI16-like PF10257.7 MSTRG.27548.2_2 - 9e-94 314.2 7.2 1.3e-93 313.7 7.2 1.2 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein DUF4211 PF13926.4 MSTRG.15511.1_2 - 1.3e-15 57.6 0.1 1.3e-15 57.6 0.1 3.5 3 1 0 3 3 3 1 Domain of unknown function (DUF4211) Troponin PF00992.18 MSTRG.15332.1_1 - 1.2e-45 155.0 7.1 1.7e-45 154.5 7.1 1.2 1 0 0 1 1 1 1 Troponin PhaP_Bmeg PF09602.8 MSTRG.15332.1_1 - 0.13 12.0 0.6 0.21 11.4 0.6 1.3 1 0 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) KBP_C PF12309.6 MSTRG.23219.1_3 - 6.8e-124 413.9 9.6 6.8e-124 413.9 9.6 1.6 2 0 0 2 2 2 1 KIF-1 binding protein C terminal TPR_7 PF13176.4 MSTRG.23219.1_3 - 0.0024 17.7 2.6 0.054 13.4 0.3 3.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.23219.1_3 - 0.0089 16.2 1.8 1 9.8 0.4 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_4 PF07721.12 MSTRG.23219.1_3 - 0.0094 16.4 0.0 9.4 7.1 0.0 3.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.23219.1_3 - 0.069 12.9 1.5 0.34 10.7 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.23219.1_3 - 0.13 12.5 4.9 2 8.6 1.1 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.23219.1_3 - 1.3 9.2 4.8 0.6 10.2 0.1 3.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.23219.1_3 - 3.3 8.4 6.6 0.34 11.5 0.2 2.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.23219.1_3 - 6.2 6.7 7.0 0.66 9.8 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat EIF4E-T PF10477.7 MSTRG.16346.1_2 - 0.0044 15.9 1.8 0.0064 15.4 1.8 1.2 1 0 0 1 1 1 1 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Homeobox PF00046.27 MSTRG.16346.1_3 - 7.4e-21 73.6 2.5 1.5e-20 72.6 2.5 1.6 1 0 0 1 1 1 1 Homeobox domain DLL_N PF12413.6 MSTRG.16346.1_3 - 1.8e-10 41.7 6.8 1.8e-10 41.7 6.8 2.2 2 0 0 2 2 2 1 Homeobox protein distal-less-like N terminal Homeobox_KN PF05920.9 MSTRG.16346.1_3 - 0.0062 16.3 0.1 0.015 15.1 0.1 1.6 1 0 0 1 1 1 1 Homeobox KN domain Myf5 PF12232.6 MSTRG.16346.1_3 - 0.1 13.2 3.3 0.33 11.6 3.3 1.8 1 0 0 1 1 1 0 Myogenic determination factor 5 Pkinase PF00069.23 MSTRG.12835.1_1 - 6.3e-71 238.7 0.0 7.9e-71 238.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.12835.1_1 - 1.3e-33 116.3 0.0 1.8e-33 115.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.12835.1_1 - 2.9e-07 30.0 0.0 4.4e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RabGAP-TBC PF00566.16 MSTRG.6785.1_2 - 6.8e-26 91.1 9.8 5.2e-12 45.8 0.1 3.2 2 1 0 2 2 2 2 Rab-GTPase-TBC domain Ephrin PF00812.15 MSTRG.12535.2_1 - 3.3e-31 108.0 0.0 4.9e-31 107.4 0.0 1.2 1 0 0 1 1 1 1 Ephrin Pkinase PF00069.23 MSTRG.4044.2_2 - 2.4e-60 204.0 0.0 3.4e-60 203.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.4044.2_2 - 2.6e-37 128.4 0.0 3.8e-37 127.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.4044.2_2 - 5.7e-06 25.7 0.0 9.5e-06 25.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.9 MSTRG.4044.2_2 - 0.0012 17.9 0.1 0.0019 17.2 0.1 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Choline_kinase PF01633.18 MSTRG.4044.2_2 - 0.15 11.5 0.4 0.5 9.8 0.0 1.9 2 0 0 2 2 2 0 Choline/ethanolamine kinase AAA PF00004.27 MSTRG.3632.2_2 - 2.7e-44 150.7 0.1 9.3e-44 148.9 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.12 MSTRG.3632.2_2 - 2e-08 34.4 0.0 5.6e-08 32.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.12 MSTRG.3632.2_2 - 1.4e-07 31.5 0.1 4.1e-07 29.9 0.1 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.4 MSTRG.3632.2_2 - 5.3e-06 26.8 0.2 0.001 19.3 0.0 2.6 2 1 0 3 3 2 1 AAA ATPase domain RuvB_N PF05496.10 MSTRG.3632.2_2 - 0.00015 21.0 0.0 0.00048 19.3 0.0 1.8 1 1 1 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus DUF815 PF05673.11 MSTRG.3632.2_2 - 0.00017 20.7 0.3 0.00051 19.1 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF815) RNA_helicase PF00910.20 MSTRG.3632.2_2 - 0.00039 20.6 0.0 0.00093 19.4 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_22 PF13401.4 MSTRG.3632.2_2 - 0.00044 20.4 0.8 0.058 13.5 0.0 2.7 1 1 1 2 2 2 1 AAA domain Mg_chelatase PF01078.19 MSTRG.3632.2_2 - 0.00074 18.8 0.1 0.0016 17.7 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.4 MSTRG.3632.2_2 - 0.0011 18.9 0.1 0.0058 16.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.13 MSTRG.3632.2_2 - 0.0015 18.3 0.1 0.16 11.7 0.0 2.8 3 0 0 3 3 3 1 NTPase AAA_28 PF13521.4 MSTRG.3632.2_2 - 0.0017 18.5 0.0 0.0036 17.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.4 MSTRG.3632.2_2 - 0.0024 17.9 0.0 0.0049 16.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.15 MSTRG.3632.2_2 - 0.0028 17.3 0.0 0.0095 15.6 0.0 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_18 PF13238.4 MSTRG.3632.2_2 - 0.0059 17.0 0.0 0.024 15.0 0.0 2.1 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.11 MSTRG.3632.2_2 - 0.0087 14.9 0.0 0.017 14.0 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus Sigma54_activat PF00158.24 MSTRG.3632.2_2 - 0.0089 15.6 0.2 0.67 9.5 0.0 2.8 3 0 0 3 3 3 1 Sigma-54 interaction domain CENP-F_leu_zip PF10473.7 MSTRG.3632.2_2 - 0.0096 15.8 0.8 0.018 15.0 0.8 1.3 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_3 PF07726.9 MSTRG.3632.2_2 - 0.013 15.2 0.1 0.19 11.5 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.15 MSTRG.3632.2_2 - 0.021 14.7 0.0 0.048 13.5 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.10 MSTRG.3632.2_2 - 0.021 14.6 2.0 0.05 13.4 0.0 2.5 3 0 0 3 3 2 0 NACHT domain ATPase_2 PF01637.16 MSTRG.3632.2_2 - 0.031 14.1 1.2 0.18 11.5 0.0 2.5 2 1 0 3 3 2 0 ATPase domain predominantly from Archaea AAA_23 PF13476.4 MSTRG.3632.2_2 - 0.06 13.7 2.2 12 6.2 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.4 MSTRG.3632.2_2 - 0.071 12.7 0.1 0.16 11.5 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.4 MSTRG.3632.2_2 - 0.072 12.5 1.9 0.15 11.5 0.1 2.1 2 1 1 3 3 3 0 AAA domain Zeta_toxin PF06414.10 MSTRG.3632.2_2 - 0.073 12.2 0.0 0.16 11.1 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin DUF3450 PF11932.6 MSTRG.3632.2_2 - 0.087 12.0 2.9 0.18 11.0 2.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) NB-ARC PF00931.20 MSTRG.3632.2_2 - 0.1 11.5 0.1 0.31 9.9 0.0 1.7 2 0 0 2 2 2 0 NB-ARC domain Parvo_NS1 PF01057.15 MSTRG.3632.2_2 - 0.11 11.4 0.0 0.2 10.6 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DivIVA PF05103.11 MSTRG.3632.2_2 - 0.38 10.7 4.9 0.19 11.7 2.3 1.8 2 0 0 2 2 1 0 DivIVA protein ICAT PF06384.9 MSTRG.18261.1_1 - 2.2e-29 101.4 0.9 2.2e-29 101.4 0.9 2.1 2 0 0 2 2 2 1 Beta-catenin-interacting protein ICAT CAMP_factor PF07373.9 MSTRG.18261.1_1 - 0.00057 19.4 0.4 0.00096 18.7 0.4 1.3 1 0 0 1 1 1 1 CAMP factor (Cfa) IncA PF04156.12 MSTRG.18261.1_1 - 0.0022 17.7 3.5 0.0038 16.9 3.5 1.4 1 0 0 1 1 1 1 IncA protein GvpG PF05120.10 MSTRG.18261.1_1 - 0.011 15.5 9.8 0.1 12.5 0.2 2.4 2 0 0 2 2 2 0 Gas vesicle protein G Serine_rich PF08824.8 MSTRG.18261.1_1 - 0.018 14.9 0.6 0.033 14.0 0.6 1.4 1 0 0 1 1 1 0 Serine rich protein interaction domain DUF3313 PF11769.6 MSTRG.18261.1_1 - 0.035 13.8 0.0 0.065 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3313) Swi5 PF07061.9 MSTRG.18261.1_1 - 0.037 13.9 1.8 0.087 12.8 1.8 1.6 1 0 0 1 1 1 0 Swi5 DMAP_binding PF06464.9 MSTRG.18261.1_1 - 0.056 14.1 0.3 0.056 14.1 0.3 2.6 3 0 0 3 3 3 0 DMAP1-binding Domain DUF1216 PF06746.9 MSTRG.18261.1_1 - 0.14 12.0 9.5 0.34 10.8 2.9 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF1216) DUF2408 PF10303.7 MSTRG.18261.1_1 - 0.74 10.2 6.8 1.3 9.5 6.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) FlxA PF14282.4 MSTRG.18261.1_1 - 2.3 8.1 9.4 3.5 7.5 7.4 2.1 1 1 1 2 2 2 0 FlxA-like protein CK2S PF15011.4 MSTRG.18261.1_1 - 3.4 7.4 9.4 12 5.6 0.0 2.5 2 1 1 3 3 3 0 Casein Kinase 2 substrate SHOCT PF09851.7 MSTRG.18261.1_1 - 6.7 6.5 11.7 20 4.9 5.4 3.1 3 0 0 3 3 3 0 Short C-terminal domain GST_C_2 PF13410.4 MSTRG.12368.1_2 - 2.9e-06 27.0 0.0 5.6e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 MSTRG.12368.1_2 - 0.00033 20.8 0.0 0.00064 19.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 MSTRG.12368.1_2 - 0.00079 19.6 0.0 0.0015 18.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_5 PF16865.3 MSTRG.12368.1_2 - 0.071 13.6 0.0 0.19 12.2 0.0 1.7 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain RRM_1 PF00076.20 MSTRG.20799.3_2 - 4.6e-11 42.2 0.0 0.011 15.4 0.0 4.3 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Bromodomain PF00439.23 MSTRG.1615.1_1 - 4.4e-13 49.0 0.0 9.6e-13 47.9 0.0 1.6 1 0 0 1 1 1 1 Bromodomain zf-B_box PF00643.22 MSTRG.1615.1_1 - 4.8e-12 45.7 21.2 1.4e-09 37.9 6.6 5.6 6 1 0 6 6 3 2 B-box zinc finger PHD PF00628.27 MSTRG.1615.1_1 - 7.5e-09 35.2 10.0 7.5e-09 35.2 10.0 4.8 5 0 0 5 5 4 1 PHD-finger zf-RING_UBOX PF13445.4 MSTRG.1615.1_1 - 2.8e-07 30.3 5.2 2.8e-07 30.3 5.2 3.8 2 1 1 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.4 MSTRG.1615.1_1 - 0.00031 20.5 6.8 0.00031 20.5 6.8 4.6 4 2 0 4 4 2 1 zinc-RING finger domain zf-C3HC4 PF00097.23 MSTRG.1615.1_1 - 0.00057 19.6 1.8 0.00057 19.6 1.8 4.9 5 0 0 5 5 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.1615.1_1 - 0.00059 19.9 7.6 0.00059 19.9 7.6 4.8 4 1 0 4 4 3 2 Ring finger domain zf-C3HC4_2 PF13923.4 MSTRG.1615.1_1 - 0.004 16.8 3.9 0.004 16.8 3.9 5.2 6 0 0 6 6 4 1 Zinc finger, C3HC4 type (RING finger) DUF1351 PF07083.9 MSTRG.1615.1_1 - 0.0067 16.1 0.7 0.014 15.0 0.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1351) DUF5054 PF16477.3 MSTRG.1615.1_1 - 0.048 13.2 0.8 0.1 12.1 0.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5054) FemAB_like PF04339.10 MSTRG.1615.1_1 - 0.049 12.6 0.6 0.081 11.9 0.6 1.2 1 0 0 1 1 1 0 Peptidogalycan biosysnthesis/recognition PRANC PF09372.8 MSTRG.1615.1_1 - 0.091 13.0 1.0 0.18 12.0 1.0 1.4 1 0 0 1 1 1 0 PRANC domain DUF148 PF02520.15 MSTRG.1615.1_1 - 0.093 12.7 6.1 0.36 10.8 5.7 2.1 1 1 1 2 2 2 0 Domain of unknown function DUF148 ParB PF08775.8 MSTRG.1615.1_1 - 0.094 13.0 2.2 0.21 11.9 2.2 1.5 1 0 0 1 1 1 0 ParB family Exonuc_VII_L PF02601.13 MSTRG.1615.1_1 - 0.32 10.4 3.4 0.54 9.6 3.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Spc7 PF08317.9 MSTRG.1615.1_1 - 0.53 9.0 8.8 1.6 7.4 8.8 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein Jnk-SapK_ap_N PF09744.7 MSTRG.1615.1_1 - 2 8.5 8.7 2.9 8.0 7.1 2.1 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 POT1 PF02765.15 MSTRG.14512.4_1 - 5.2e-09 36.0 0.0 9.4e-09 35.1 0.0 1.3 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 POT1PC PF16686.3 MSTRG.14512.4_3 - 1.3e-33 115.9 0.0 2e-33 115.3 0.0 1.3 1 0 0 1 1 1 1 ssDNA-binding domain of telomere protection protein zf-AD PF07776.13 MSTRG.24167.1_1 - 5.2e-08 32.9 0.2 1.8e-07 31.2 0.2 2.0 1 0 0 1 1 1 1 Zinc-finger associated domain (zf-AD) CUT PF02376.13 MSTRG.17954.4_3 - 7.7e-25 86.7 0.0 2.9e-24 84.9 0.0 2.0 1 0 0 1 1 1 1 CUT domain DegS PF05384.9 MSTRG.17954.4_3 - 0.015 14.6 0.8 0.015 14.6 0.8 4.3 2 1 1 3 3 3 0 Sensor protein DegS ApoO PF09769.7 MSTRG.17954.4_3 - 0.59 10.0 12.5 5.4 6.9 1.3 4.1 3 1 1 4 4 4 0 Apolipoprotein O 7tm_2 PF00002.22 MSTRG.283.1_1 - 4.5e-60 202.8 26.6 9.7e-60 201.8 26.6 1.6 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.19 MSTRG.283.1_1 - 9.3e-15 54.9 8.2 2.7e-14 53.4 8.2 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif EGF_CA PF07645.13 MSTRG.283.1_1 - 8.8e-11 41.7 38.7 5.7e-07 29.5 3.9 4.1 3 0 0 3 3 3 2 Calcium-binding EGF domain EGF_3 PF12947.5 MSTRG.283.1_1 - 0.0004 20.4 14.3 0.0021 18.1 2.2 4.9 4 1 1 5 5 5 2 EGF domain cEGF PF12662.5 MSTRG.283.1_1 - 0.013 15.3 0.6 0.013 15.3 0.6 4.1 4 0 0 4 4 4 0 Complement Clr-like EGF-like ArAE_2_N PF10337.7 MSTRG.22510.1_1 - 0.6 8.9 1.8 1.2 7.9 1.8 1.4 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal DUF972 PF06156.11 MSTRG.22510.1_1 - 5.8 7.5 6.2 0.6 10.6 0.3 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF972) Ribosomal_S9 PF00380.17 MSTRG.24765.2_2 - 1e-22 80.8 0.0 3.5e-22 79.1 0.0 1.9 3 0 0 3 3 3 1 Ribosomal protein S9/S16 Ribosomal_S9 PF00380.17 MSTRG.24765.2_3 - 2.9e-08 34.2 0.6 4.5e-08 33.6 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein S9/S16 V-set PF07686.15 MSTRG.18885.1_3 - 3.7e-13 49.5 0.1 6.2e-13 48.7 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.14 MSTRG.18885.1_3 - 0.051 13.5 0.0 0.086 12.8 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.18885.1_3 - 0.087 13.3 0.0 0.16 12.4 0.0 1.5 1 1 0 1 1 1 0 Immunoglobulin domain Glyco_hydro_79n PF03662.12 MSTRG.9063.2_2 - 5.6e-10 38.6 0.0 9.5e-10 37.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 79, N-terminal domain Glyco_hydro_79n PF03662.12 MSTRG.9063.2_3 - 2.9e-08 32.9 0.0 7.2e-07 28.3 0.1 2.1 2 0 0 2 2 2 2 Glycosyl hydrolase family 79, N-terminal domain HlyIII PF03006.18 MSTRG.9866.2_3 - 1.4e-37 129.5 2.9 3.2e-37 128.3 2.9 1.5 1 1 0 1 1 1 1 Haemolysin-III related FSAP_sig_propep PF03032.13 MSTRG.9866.2_3 - 0.2 11.6 6.7 0.73 9.8 6.7 2.0 1 0 0 1 1 1 0 Frog skin active peptide family signal and propeptide Methyltrn_RNA_3 PF02598.15 MSTRG.8728.3_1 - 1.9e-25 89.8 0.3 3.2e-25 89.1 0.0 1.5 2 0 0 2 2 2 1 Putative RNA methyltransferase Adaptin_binding PF10199.7 MSTRG.8728.3_1 - 0.0053 17.2 0.2 0.0066 16.9 0.2 1.2 1 0 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 Cytadhesin_P30 PF07271.9 MSTRG.8728.3_1 - 0.16 11.4 2.8 0.21 11.0 2.8 1.1 1 0 0 1 1 1 0 Cytadhesin P30/P32 NARG2_C PF10505.7 MSTRG.8728.3_2 - 0.1 12.0 0.2 0.13 11.7 0.2 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated gene protein 2 C-terminus RasGEF PF00617.17 MSTRG.24043.1_2 - 2e-53 180.9 0.3 3e-53 180.4 0.3 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.18 MSTRG.24043.1_2 - 6.4e-20 71.2 0.2 4e-19 68.7 0.0 2.4 3 0 0 3 3 3 1 RasGEF N-terminal motif RabGAP-TBC PF00566.16 MSTRG.27604.4_1 - 8.7e-46 156.1 0.0 2e-45 155.0 0.0 1.7 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.18 MSTRG.27604.4_1 - 3.5e-41 139.5 0.3 4.9e-22 77.8 0.0 2.5 2 0 0 2 2 2 2 GRAM domain EF-hand_1 PF00036.30 MSTRG.27604.4_1 - 0.0042 16.4 0.2 0.02 14.3 0.1 2.3 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 MSTRG.27604.4_1 - 0.02 14.7 0.1 0.093 12.6 0.1 2.2 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.4 MSTRG.27604.4_1 - 0.13 12.6 1.6 0.38 11.1 0.0 2.5 2 1 1 3 3 3 0 EF-hand domain pair Spp-24 PF07448.9 MSTRG.10415.1_2 - 0.019 15.0 0.0 0.05 13.7 0.0 1.7 1 0 0 1 1 1 0 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain C1q PF00386.19 MSTRG.10415.1_2 - 0.07 13.2 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 C1q domain Med9 PF07544.11 MSTRG.13563.1_2 - 0.18 11.8 10.3 0.28 11.2 0.7 3.4 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 DUF4446 PF14584.4 MSTRG.13563.1_2 - 4.6 7.1 7.0 1 9.2 1.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) DUF4797 PF16051.3 MSTRG.13563.1_3 - 0.019 14.7 0.2 0.046 13.5 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4797) Homeobox PF00046.27 MSTRG.10288.2_3 - 5.2e-06 26.1 0.9 8.2e-06 25.4 0.9 1.3 1 0 0 1 1 1 1 Homeobox domain EF-hand_7 PF13499.4 MSTRG.22503.2_3 - 9e-09 35.6 1.7 9e-09 35.6 1.7 3.1 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.22503.2_3 - 4.9e-06 25.9 0.9 0.0005 19.7 0.7 2.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.30 MSTRG.22503.2_3 - 5.3e-06 25.5 1.1 0.031 13.7 1.1 2.9 2 0 0 2 2 2 2 EF hand Hormone_recep PF00104.28 MSTRG.10661.1_1 - 3.1e-37 128.1 0.0 4.8e-37 127.4 0.0 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 MSTRG.10661.1_1 - 8.4e-32 109.3 17.3 2.4e-31 107.9 17.3 1.8 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Gin PF10764.7 MSTRG.10661.1_1 - 5.6 6.9 8.4 3.4 7.6 1.1 2.8 3 0 0 3 3 3 0 Inhibitor of sigma-G Gin SPRY PF00622.26 MSTRG.6432.1_3 - 2.2e-17 63.2 0.1 4.4e-17 62.2 0.1 1.5 1 0 0 1 1 1 1 SPRY domain TUDOR PF00567.22 MSTRG.6652.2_1 - 8.4e-21 74.1 0.1 1.6e-20 73.2 0.1 1.4 1 0 0 1 1 1 1 Tudor domain OST-HTH PF12872.5 MSTRG.6652.2_1 - 0.042 13.6 0.0 0.086 12.6 0.0 1.5 1 0 0 1 1 1 0 OST-HTH/LOTUS domain MBOAT PF03062.17 MSTRG.4257.2_3 - 1.7e-11 43.9 17.6 4.2e-11 42.7 17.6 1.6 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Methyltransf_25 PF13649.4 MSTRG.15827.2_1 - 3.5e-42 142.9 0.0 7.8e-20 71.3 0.0 3.1 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_11 PF08241.10 MSTRG.15827.2_1 - 1.9e-40 137.3 0.0 1.8e-18 66.8 0.0 3.2 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_23 PF13489.4 MSTRG.15827.2_1 - 2.6e-34 118.4 0.0 1.8e-21 76.6 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.4 MSTRG.15827.2_1 - 6e-32 110.4 0.0 4.8e-16 58.8 0.0 2.7 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.10 MSTRG.15827.2_1 - 1.6e-24 86.4 0.2 4.6e-11 43.2 0.0 3.1 4 0 0 4 4 2 2 Methyltransferase domain Ubie_methyltran PF01209.16 MSTRG.15827.2_1 - 5e-20 71.7 0.0 1.2e-10 41.0 0.0 2.8 2 1 1 3 3 3 2 ubiE/COQ5 methyltransferase family CMAS PF02353.18 MSTRG.15827.2_1 - 1.8e-17 63.4 0.0 4.2e-14 52.4 0.0 2.2 2 0 0 2 2 2 2 Mycolic acid cyclopropane synthetase Methyltransf_PK PF05891.10 MSTRG.15827.2_1 - 4.3e-14 52.4 0.0 5.9e-11 42.2 0.0 2.8 3 0 0 3 3 3 2 AdoMet dependent proline di-methyltransferase TehB PF03848.12 MSTRG.15827.2_1 - 3.3e-13 49.4 0.0 4.5e-07 29.3 0.0 2.3 2 0 0 2 2 2 2 Tellurite resistance protein TehB CheR PF01739.16 MSTRG.15827.2_1 - 4.1e-11 42.6 0.0 0.00024 20.5 0.0 3.6 3 1 1 4 4 4 2 CheR methyltransferase, SAM binding domain PCMT PF01135.17 MSTRG.15827.2_1 - 9.2e-11 41.8 0.0 1.4e-06 28.1 0.0 2.2 2 0 0 2 2 2 2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) NodS PF05401.9 MSTRG.15827.2_1 - 1.4e-10 41.0 0.0 4e-09 36.2 0.0 2.3 2 0 0 2 2 2 1 Nodulation protein S (NodS) RrnaAD PF00398.18 MSTRG.15827.2_1 - 2.1e-10 40.0 0.0 9.8e-08 31.2 0.0 2.3 2 0 0 2 2 2 2 Ribosomal RNA adenine dimethylase MTS PF05175.12 MSTRG.15827.2_1 - 6.6e-10 38.7 0.0 0.00084 18.8 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase small domain Methyltransf_9 PF08003.9 MSTRG.15827.2_1 - 2.4e-07 29.9 0.0 5.1e-05 22.2 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1698) Methyltransf_2 PF00891.16 MSTRG.15827.2_1 - 5.3e-07 28.9 0.0 0.0044 16.1 0.0 2.2 2 0 0 2 2 2 2 O-methyltransferase MetW PF07021.10 MSTRG.15827.2_1 - 8e-07 28.7 0.0 8.3e-05 22.1 0.0 2.2 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW PrmA PF06325.11 MSTRG.15827.2_1 - 2.4e-05 23.7 0.0 0.011 15.0 0.0 2.6 3 0 0 3 3 3 1 Ribosomal protein L11 methyltransferase (PrmA) FtsJ PF01728.17 MSTRG.15827.2_1 - 8.4e-05 22.6 0.0 0.058 13.4 0.0 2.4 2 0 0 2 2 2 2 FtsJ-like methyltransferase TPMT PF05724.9 MSTRG.15827.2_1 - 0.0004 20.0 0.0 0.017 14.6 0.0 2.4 2 0 0 2 2 2 1 Thiopurine S-methyltransferase (TPMT) DOT1 PF08123.11 MSTRG.15827.2_1 - 0.00077 18.9 0.1 0.0092 15.4 0.0 2.4 2 1 0 2 2 2 1 Histone methylation protein DOT1 Methyltransf_32 PF13679.4 MSTRG.15827.2_1 - 0.0015 18.5 0.0 0.18 11.7 0.0 2.7 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_4 PF02390.15 MSTRG.15827.2_1 - 0.0063 15.9 0.0 0.36 10.1 0.0 2.5 2 0 0 2 2 2 1 Putative methyltransferase Bin3 PF06859.10 MSTRG.15827.2_1 - 0.014 15.9 0.7 1.2 9.7 0.2 3.4 2 1 1 3 3 3 0 Bicoid-interacting protein 3 (Bin3) UPF0020 PF01170.16 MSTRG.15827.2_1 - 0.03 13.9 0.0 4.4 6.8 0.0 2.4 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 Atrophin-1 PF03154.13 MSTRG.15827.2_1 - 8.6 4.4 7.6 11 4.0 7.6 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF4630 PF15443.4 MSTRG.10494.1_2 - 8.7e-07 29.1 0.0 1.5e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4630) DUF1560 PF07597.9 MSTRG.8554.3_2 - 5.7 6.9 6.7 14 5.7 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1560) MA3 PF02847.15 MSTRG.8554.3_3 - 7.2e-23 80.6 1.1 7.2e-23 80.6 1.1 1.9 2 0 0 2 2 2 1 MA3 domain MIF4G PF02854.17 MSTRG.8554.3_3 - 1.4e-10 41.1 1.8 3.1e-10 40.0 1.8 1.6 1 0 0 1 1 1 1 MIF4G domain Coilin_N PF15862.3 MSTRG.8554.3_3 - 0.0073 16.0 3.1 0.0073 16.0 3.1 3.7 4 0 0 4 4 4 1 Coilin N-terminus Cnd1 PF12717.5 MSTRG.8554.3_3 - 0.059 13.2 0.2 0.14 12.1 0.2 1.5 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 SSP160 PF06933.9 MSTRG.8554.3_3 - 0.44 8.6 10.1 1.1 7.3 10.1 1.6 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 AF-4 PF05110.11 MSTRG.8554.3_3 - 4.6 5.1 52.5 0.0024 15.9 25.4 2.4 2 0 0 2 2 2 0 AF-4 proto-oncoprotein PSP94 PF05825.9 MSTRG.16895.3_2 - 2.2e-06 28.0 5.8 3.5e-06 27.3 5.8 1.3 1 0 0 1 1 1 1 Beta-microseminoprotein (PSP-94) Homeobox PF00046.27 MSTRG.16345.1_2 - 2.2e-20 72.1 2.8 4.4e-20 71.1 2.8 1.5 1 0 0 1 1 1 1 Homeobox domain Homez PF11569.6 MSTRG.16345.1_2 - 0.054 12.8 0.2 0.11 11.8 0.2 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.9 MSTRG.16345.1_2 - 0.086 12.6 0.1 0.086 12.6 0.1 2.0 2 0 0 2 2 2 0 Homeobox KN domain Choline_transpo PF04515.10 MSTRG.11567.1_2 - 1.8e-101 339.5 36.7 1.8e-101 339.5 36.7 2.9 2 1 1 3 3 3 1 Plasma-membrane choline transporter Rap_GAP PF02145.13 MSTRG.4391.1_2 - 4.2e-64 215.4 0.1 6.1e-64 214.9 0.1 1.3 1 0 0 1 1 1 1 Rap/ran-GAP GoLoco PF02188.15 MSTRG.4391.1_2 - 0.0025 17.2 0.0 0.0046 16.3 0.0 1.5 1 0 0 1 1 1 1 GoLoco motif ABC_tran PF00005.25 MSTRG.16420.1_2 - 9.5e-16 58.4 0.0 1.5e-15 57.8 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_30 PF13604.4 MSTRG.16420.1_2 - 3.2e-05 23.6 0.0 0.0013 18.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.4 MSTRG.16420.1_2 - 0.00018 21.8 0.0 0.00032 21.0 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 MSTRG.16420.1_2 - 0.0041 17.3 0.0 0.033 14.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain DEAD PF00270.27 MSTRG.16420.1_2 - 0.012 15.2 0.0 0.051 13.2 0.0 1.8 1 1 0 1 1 1 0 DEAD/DEAH box helicase FtsK_SpoIIIE PF01580.16 MSTRG.16420.1_2 - 0.019 14.2 0.0 0.029 13.6 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family T2SSE PF00437.18 MSTRG.16420.1_2 - 0.024 13.6 0.0 0.037 13.0 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_5 PF07728.12 MSTRG.16420.1_2 - 0.025 14.4 0.0 0.05 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_21 PF13304.4 MSTRG.16420.1_2 - 0.034 13.8 0.0 0.048 13.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system NACHT PF05729.10 MSTRG.16420.1_2 - 0.044 13.6 0.0 0.074 12.8 0.0 1.3 1 0 0 1 1 1 0 NACHT domain DUF87 PF01935.15 MSTRG.16420.1_2 - 0.058 13.3 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF87 Sigma54_activat PF00158.24 MSTRG.16420.1_2 - 0.12 12.0 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain UDG PF03167.17 MSTRG.3072.2_1 - 2.5e-23 82.6 0.1 4.7e-23 81.8 0.1 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily PAD PF03068.13 MSTRG.2638.2_2 - 2.9e-164 546.5 0.0 3.8e-164 546.1 0.0 1.1 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) PAD_M PF08527.8 MSTRG.2638.2_2 - 1.5e-59 200.1 0.0 2.4e-59 199.4 0.0 1.4 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) middle domain PAD_N PF08526.8 MSTRG.2638.2_2 - 4.2e-31 107.5 0.2 7.1e-31 106.8 0.2 1.4 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) N-terminal domain Peptidase_C48 PF02902.17 MSTRG.11940.1_2 - 6.3e-49 166.6 0.9 1.1e-48 165.8 0.9 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Lipocalin PF00061.21 MSTRG.8603.1_3 - 7e-16 58.6 0.0 1.1e-15 58.0 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_2 PF08212.10 MSTRG.8603.1_3 - 4.1e-07 29.9 0.0 6.3e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Lipocalin-like domain Triabin PF03973.11 MSTRG.8603.1_3 - 3.9e-05 23.4 0.1 0.0006 19.6 0.0 2.1 2 0 0 2 2 2 1 Triabin VDE PF07137.9 MSTRG.8603.1_3 - 0.015 15.1 0.1 0.022 14.6 0.1 1.2 1 0 0 1 1 1 0 VDE lipocalin domain SNF PF00209.16 MSTRG.21847.1_3 - 6.9e-239 793.7 37.1 8.6e-239 793.4 37.1 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Pkinase PF00069.23 MSTRG.7591.1_3 - 8.7e-69 231.7 0.0 1.1e-68 231.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.7591.1_3 - 8.2e-46 156.2 0.0 1.2e-45 155.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 MSTRG.7591.1_3 - 7.8e-12 45.3 0.0 1.7e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 MSTRG.7591.1_3 - 2.6e-06 26.8 0.0 3.9e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 MSTRG.7591.1_3 - 0.018 14.2 0.2 0.035 13.3 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 MSTRG.7591.1_3 - 0.14 12.0 0.5 3.4 7.4 0.1 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Jiraiya PF15038.4 MSTRG.5398.1_2 - 4.1 6.7 8.6 9.4 5.5 0.2 3.5 3 1 0 3 3 3 0 Jiraiya zf-C3HC4_5 PF17121.3 MSTRG.7517.3_1 - 9e-12 44.6 7.0 1.6e-11 43.7 7.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) MAT1 PF06391.11 MSTRG.7517.3_1 - 5e-11 42.7 1.5 6.3e-11 42.3 1.5 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-UDP PF14569.4 MSTRG.7517.3_1 - 9.9e-06 25.5 5.8 0.0083 16.1 2.2 2.2 1 1 1 2 2 2 2 Zinc-binding RING-finger zf-RING_UBOX PF13445.4 MSTRG.7517.3_1 - 4.9e-05 23.1 6.6 0.00011 22.0 6.6 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.4 MSTRG.7517.3_1 - 0.00027 20.7 8.7 0.00084 19.1 8.6 1.8 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.23 MSTRG.7517.3_1 - 0.0047 16.6 8.8 0.023 14.4 9.0 2.0 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.7517.3_1 - 0.0067 16.5 6.8 0.012 15.7 6.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_6 PF14835.4 MSTRG.7517.3_1 - 0.033 13.9 1.6 0.062 13.1 1.6 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-P11 PF03854.12 MSTRG.7517.3_1 - 0.047 13.2 5.9 0.1 12.1 5.9 1.6 1 1 0 1 1 1 0 P-11 zinc finger DZR PF12773.5 MSTRG.7517.3_1 - 0.047 13.6 6.8 0.26 11.2 6.8 2.1 1 1 0 1 1 1 0 Double zinc ribbon zf-RING_4 PF14570.4 MSTRG.7517.3_1 - 0.23 11.1 4.6 3.3 7.4 0.9 2.2 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.4 MSTRG.7517.3_1 - 0.26 11.3 7.4 0.33 11.0 3.7 2.5 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 MSTRG.7517.3_1 - 0.3 10.8 10.1 3.3 7.5 10.4 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 MSTRG.7517.3_1 - 0.65 9.8 10.2 0.3 10.8 3.1 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 BCMA-Tall_bind PF09257.8 MSTRG.7517.3_2 - 2 8.4 9.9 0.4 10.6 3.3 2.5 2 0 0 2 2 2 0 BCMA, TALL-1 binding eIF-1a PF01176.17 MSTRG.1106.3_3 - 1.2e-20 72.9 0.1 2e-20 72.2 0.1 1.4 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 TBP PF00352.19 MSTRG.1296.1_1 - 2.8e-66 219.4 0.1 6.8e-32 109.1 0.0 2.2 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.6 MSTRG.1296.1_1 - 0.00035 20.5 0.0 0.66 10.0 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) HCO3_cotransp PF00955.19 MSTRG.11184.3_1 - 3.3e-228 758.5 4.1 5e-228 757.9 4.1 1.3 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 MSTRG.11184.3_1 - 2.7e-100 335.5 0.1 5.5e-100 334.5 0.1 1.5 1 0 0 1 1 1 1 Band 3 cytoplasmic domain PTS_EIIA_2 PF00359.20 MSTRG.11184.3_1 - 0.00054 19.7 0.0 0.012 15.3 0.0 2.3 2 0 0 2 2 2 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 Xan_ur_permease PF00860.18 MSTRG.11184.3_1 - 0.16 10.5 14.9 0.24 9.9 1.7 2.8 3 0 0 3 3 3 0 Permease family Fmp27_WPPW PF10359.7 MSTRG.11184.3_1 - 1.5 7.5 5.8 0.12 11.1 0.1 1.8 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain PP2C PF00481.19 MSTRG.9990.1_2 - 4e-59 200.2 0.0 5.6e-59 199.7 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.4 MSTRG.9990.1_2 - 4.1e-07 29.7 0.0 1.7e-06 27.7 0.0 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.10 MSTRG.9990.1_2 - 0.011 15.5 0.0 0.12 12.1 0.0 2.1 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) DUF4420 PF14390.4 MSTRG.27452.1_2 - 0.058 12.5 0.0 0.08 12.0 0.0 1.1 1 0 0 1 1 1 0 Putative PD-(D/E)XK family member, (DUF4420) PIP5K PF01504.16 MSTRG.6163.1_1 - 3.6e-88 295.2 0.0 3.6e-88 295.2 0.0 1.7 2 0 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase FAM110_N PF14161.4 MSTRG.553.1_2 - 3.7e-43 146.2 0.2 9e-43 145.0 0.2 1.6 1 0 0 1 1 1 1 Centrosome-associated N terminus FAM110_C PF14160.4 MSTRG.553.1_2 - 7.7e-33 113.8 1.7 1.1e-32 113.3 0.0 2.0 2 0 0 2 2 2 1 Centrosome-associated C terminus V-ATPase_C PF03223.13 MSTRG.116.1_3 - 3.1e-167 556.5 10.3 3.6e-167 556.3 10.3 1.0 1 0 0 1 1 1 1 V-ATPase subunit C SAM_1 PF00536.28 MSTRG.22004.2_3 - 8.8e-14 51.6 0.0 1.4e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 MSTRG.22004.2_3 - 2.9e-09 36.8 0.0 5.1e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 MSTRG.22004.2_3 - 0.0027 17.5 0.0 0.0054 16.5 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain P66_CC PF16563.3 MSTRG.23593.2_1 - 6.5e-18 63.9 12.3 6.5e-18 63.9 12.3 1.9 2 0 0 2 2 2 1 Coiled-coil and interaction region of P66A and P66B with MBD2 GATA PF00320.25 MSTRG.23593.2_1 - 2.6e-09 36.4 5.0 8.1e-09 34.8 5.0 1.9 1 0 0 1 1 1 1 GATA zinc finger Zn-ribbon_8 PF09723.8 MSTRG.23593.2_1 - 0.067 13.2 0.7 0.2 11.6 0.7 1.9 1 0 0 1 1 1 0 Zinc ribbon domain ArfGap PF01412.16 MSTRG.23593.2_1 - 0.4 10.6 3.4 0.6 10.0 2.4 1.8 1 1 0 1 1 1 0 Putative GTPase activating protein for Arf FAM76 PF16046.3 MSTRG.23593.2_1 - 0.49 9.6 20.1 0.2 10.9 7.9 2.2 2 0 0 2 2 2 0 FAM76 protein PI3K_P85_iSH2 PF16454.3 MSTRG.18821.1_3 - 9.8e-59 197.4 25.2 1.4e-58 196.9 25.2 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain SH2 PF00017.22 MSTRG.18821.1_3 - 5.8e-41 138.3 0.2 2.2e-21 75.6 0.0 2.5 2 0 0 2 2 2 2 SH2 domain RhoGAP PF00620.25 MSTRG.18821.1_3 - 1.2e-20 73.8 1.7 1.2e-20 73.8 0.0 1.8 2 1 1 3 3 3 1 RhoGAP domain SH3_9 PF14604.4 MSTRG.18821.1_3 - 0.0032 17.1 0.1 0.0077 15.9 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.18821.1_3 - 0.011 15.2 0.2 0.11 11.9 0.0 2.4 2 0 0 2 2 2 0 SH3 domain SKA2 PF16740.3 MSTRG.18821.1_3 - 0.098 12.3 3.4 0.22 11.2 3.4 1.5 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 Asp-B-Hydro_N PF05279.9 MSTRG.18821.1_3 - 0.49 10.3 7.9 0.73 9.7 7.9 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Mod_r PF07200.11 MSTRG.18821.1_3 - 0.59 10.1 25.1 0.59 10.1 6.8 2.5 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Laminin_I PF06008.12 MSTRG.18821.1_3 - 1.1 8.7 17.1 5 6.6 17.1 1.8 1 1 0 1 1 1 0 Laminin Domain I AbLIM_anchor PF16182.3 MSTRG.14770.1_2 - 1.6e-39 136.7 1.4 2.2e-39 136.2 1.4 1.2 1 0 0 1 1 1 1 Putative adherens-junction anchoring region of AbLIM VHP PF02209.17 MSTRG.14770.1_2 - 2.9e-14 52.7 1.5 6.8e-14 51.5 1.5 1.7 1 0 0 1 1 1 1 Villin headpiece domain ATP-grasp_2 PF08442.8 MSTRG.8571.1_3 - 1.4e-70 236.8 0.3 2.1e-70 236.3 0.3 1.3 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.17 MSTRG.8571.1_3 - 1.6e-25 89.5 1.2 2.5e-25 88.9 1.2 1.3 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.4 MSTRG.8571.1_3 - 7.1e-09 35.3 0.1 1.3e-08 34.5 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.17 MSTRG.8571.1_3 - 0.083 12.5 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain CPSase_L_D2 PF02786.15 MSTRG.8571.1_3 - 0.38 10.1 1.2 1.4 8.3 0.3 2.0 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, ATP binding domain DZR PF12773.5 MSTRG.23161.3_3 - 0.23 11.4 0.1 0.23 11.4 0.1 5.2 4 2 0 4 4 4 0 Double zinc ribbon ANF_receptor PF01094.26 MSTRG.17049.1_1 - 4.4e-14 52.2 0.0 5.1e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region DEAD PF00270.27 MSTRG.938.1_2 - 2.8e-49 167.1 0.0 7.1e-49 165.8 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.938.1_2 - 6.6e-27 94.0 0.0 1.8e-25 89.3 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain C2 PF00168.28 MSTRG.26851.2_3 - 5.2e-14 52.2 0.0 7e-14 51.8 0.0 1.1 1 0 0 1 1 1 1 C2 domain DUF1279 PF06916.11 MSTRG.13454.1_3 - 3.8e-22 78.5 1.2 8e-22 77.5 1.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) Apolipoprotein PF01442.16 MSTRG.13454.1_3 - 1.1e-07 31.9 5.2 1.6e-07 31.3 5.2 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain YtxH PF12732.5 MSTRG.13454.1_3 - 0.0003 21.1 10.5 0.00079 19.8 10.5 1.8 1 0 0 1 1 1 1 YtxH-like protein LEA_4 PF02987.14 MSTRG.13454.1_3 - 0.00052 19.9 11.8 0.0033 17.4 3.6 2.2 1 1 1 2 2 2 2 Late embryogenesis abundant protein DUF883 PF05957.11 MSTRG.13454.1_3 - 0.013 15.9 2.8 0.023 15.2 2.8 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) TipAS PF07739.11 MSTRG.13454.1_3 - 0.03 14.7 6.5 0.06 13.8 6.5 1.4 1 0 0 1 1 1 0 TipAS antibiotic-recognition domain FUN14 PF04930.13 MSTRG.13454.1_3 - 0.053 13.8 0.0 0.1 12.9 0.0 1.5 1 0 0 1 1 1 0 FUN14 family DUF4508 PF14969.4 MSTRG.13454.1_3 - 0.13 12.4 6.1 9.5 6.4 1.4 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4508) Sds3 PF08598.9 MSTRG.13454.1_3 - 0.17 11.7 6.3 0.25 11.2 6.3 1.1 1 0 0 1 1 1 0 Sds3-like DUF1664 PF07889.10 MSTRG.13454.1_3 - 0.72 9.7 4.1 1.7 8.5 4.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF342 PF03961.11 MSTRG.13454.1_3 - 0.77 8.2 4.5 1 7.7 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF573 PF04504.12 MSTRG.13454.1_3 - 1 10.0 7.5 0.33 11.5 4.5 1.8 2 0 0 2 2 1 0 Protein of unknown function, DUF573 TMPIT PF07851.11 MSTRG.13454.1_3 - 6.3 5.8 6.6 9.7 5.2 6.6 1.2 1 0 0 1 1 1 0 TMPIT-like protein Gpi1 PF05024.13 MSTRG.19471.1_3 - 8.7e-64 215.0 9.1 1.5e-63 214.2 9.1 1.4 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) Lig_chan-Glu_bd PF10613.7 MSTRG.2538.1_2 - 2.3e-31 108.2 0.1 4.7e-30 104.0 0.1 2.3 1 1 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site ANF_receptor PF01094.26 MSTRG.2538.1_2 - 1.4e-11 44.0 0.0 6e-10 38.6 0.0 2.1 1 1 0 1 1 1 1 Receptor family ligand binding region SBP_bac_3 PF00497.18 MSTRG.2538.1_2 - 2.2e-10 40.2 0.0 4e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 POT1 PF02765.15 MSTRG.14512.5_1 - 5e-09 36.0 0.0 9.2e-09 35.1 0.0 1.3 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 POT1PC PF16686.3 MSTRG.14512.5_3 - 1.3e-33 116.0 0.0 2e-33 115.4 0.0 1.3 1 0 0 1 1 1 1 ssDNA-binding domain of telomere protection protein FAM199X PF15814.3 MSTRG.22260.1_3 - 4.4 6.1 4.8 5 6.0 4.8 1.0 1 0 0 1 1 1 0 Protein family FAM199X EphA2_TM PF14575.4 MSTRG.19639.1_2 - 0.01 16.5 0.1 0.021 15.5 0.1 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain CD34_antigen PF06365.10 MSTRG.19639.1_2 - 0.011 15.2 0.2 0.019 14.5 0.2 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family EGF PF00008.25 MSTRG.19639.1_2 - 0.013 15.7 5.0 0.013 15.7 5.0 2.0 2 0 0 2 2 2 0 EGF-like domain TMEM154 PF15102.4 MSTRG.19639.1_2 - 0.019 14.7 0.0 0.033 14.0 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family Shisa PF13908.4 MSTRG.19639.1_2 - 2 8.5 10.2 10 6.2 10.2 1.9 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator GST_C_2 PF13410.4 MSTRG.19629.1_1 - 1.1e-06 28.4 0.0 2.2e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.4 MSTRG.19629.1_1 - 0.00012 22.2 0.0 0.00029 21.0 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.4 MSTRG.19629.1_1 - 0.00015 21.9 0.0 0.00026 21.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 MSTRG.19629.1_1 - 0.056 13.5 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DEP PF00610.19 MSTRG.15258.1_1 - 5.3e-14 51.9 0.0 9.5e-14 51.1 0.0 1.4 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF676 PF05057.12 MSTRG.7694.1_1 - 2e-60 203.9 0.0 3.5e-60 203.1 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF3657 PF12394.6 MSTRG.7694.1_1 - 9.8e-17 61.1 1.2 2.3e-16 59.9 0.3 2.2 2 0 0 2 2 2 1 Protein FAM135 PGAP1 PF07819.11 MSTRG.7694.1_1 - 0.0001 21.9 0.1 0.00031 20.4 0.0 1.8 2 0 0 2 2 2 1 PGAP1-like protein LCAT PF02450.13 MSTRG.7694.1_1 - 0.0081 15.2 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Ras PF00071.20 MSTRG.2715.1_1 - 4.5e-54 182.3 0.0 6.3e-54 181.8 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.2715.1_1 - 2.5e-34 118.0 0.0 3.8e-34 117.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.2715.1_1 - 1.1e-13 50.9 0.0 1.5e-13 50.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 MSTRG.2715.1_1 - 0.0007 19.5 0.0 0.0013 18.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 MSTRG.2715.1_1 - 0.00079 18.7 0.0 0.0011 18.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 MSTRG.2715.1_1 - 0.0017 17.8 0.0 0.0029 17.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 MSTRG.2715.1_1 - 0.0059 16.4 0.0 0.43 10.3 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 Ashwin PF15323.4 MSTRG.22327.4_1 - 9.6e-12 45.3 9.6 4.7e-11 43.0 9.6 1.8 1 1 0 1 1 1 1 Developmental protein SR-25 PF10500.7 MSTRG.22327.4_1 - 4.7 6.6 12.2 6.8 6.1 12.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ashwin PF15323.4 MSTRG.22327.4_2 - 7.2e-15 55.5 0.4 1e-14 55.0 0.4 1.1 1 0 0 1 1 1 1 Developmental protein ASFV_J13L PF05568.9 MSTRG.22327.4_2 - 2.2 7.8 5.2 3.4 7.2 5.2 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein TMEM154 PF15102.4 MSTRG.22327.4_2 - 3.1 7.6 4.9 5 6.9 4.9 1.2 1 0 0 1 1 1 0 TMEM154 protein family DUF4834 PF16118.3 MSTRG.22327.4_2 - 5.8 7.8 5.3 9.7 7.1 5.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Ashwin PF15323.4 MSTRG.22327.4_3 - 2.4e-33 115.9 21.0 1.5e-27 97.0 14.4 3.7 2 1 0 2 2 2 2 Developmental protein ASFV_J13L PF05568.9 MSTRG.22327.4_3 - 1.5 8.4 5.2 3.4 7.2 5.2 1.5 1 0 0 1 1 1 0 African swine fever virus J13L protein SR-25 PF10500.7 MSTRG.22327.4_3 - 3.6 7.0 12.8 5.7 6.4 12.8 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4834 PF16118.3 MSTRG.22327.4_3 - 9 7.2 6.6 13 6.6 5.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Lipocalin PF00061.21 MSTRG.8800.1_3 - 8.1e-22 77.8 3.8 1.2e-21 77.3 3.8 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 MSTRG.8800.1_3 - 0.0079 16.0 1.8 0.012 15.4 1.8 1.3 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family MAGUK_N_PEST PF10608.7 MSTRG.9411.1_1 - 5.5e-17 62.2 0.3 6.7e-17 62.0 0.3 1.1 1 0 0 1 1 1 1 Polyubiquitination (PEST) N-terminal domain of MAGUK MAM PF00629.21 MSTRG.28566.1_2 - 0.15 11.8 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 MAM domain, meprin/A5/mu EGF_CA PF07645.13 MSTRG.18665.1_2 - 7.2e-17 61.2 21.9 9.5e-11 41.6 7.4 2.2 2 0 0 2 2 2 2 Calcium-binding EGF domain cEGF PF12662.5 MSTRG.18665.1_2 - 5.9e-10 38.8 5.7 1.8e-06 27.6 0.7 2.7 3 0 0 3 3 3 2 Complement Clr-like EGF-like Plasmod_Pvs28 PF06247.9 MSTRG.18665.1_2 - 2.2e-07 30.9 17.3 9.9e-05 22.4 5.6 2.3 2 0 0 2 2 2 2 Pvs28 EGF domain EGF_3 PF12947.5 MSTRG.18665.1_2 - 2.7e-07 30.5 18.5 0.002 18.2 3.7 2.3 2 0 0 2 2 2 2 EGF domain EGF PF00008.25 MSTRG.18665.1_2 - 2.1e-06 27.7 21.5 0.00018 21.6 8.7 2.6 3 0 0 3 3 3 2 EGF-like domain FXa_inhibition PF14670.4 MSTRG.18665.1_2 - 8.3e-06 25.9 17.5 0.011 15.9 8.0 2.3 2 0 0 2 2 2 2 Coagulation Factor Xa inhibitory site EGF_MSP1_1 PF12946.5 MSTRG.18665.1_2 - 8.9e-06 25.5 16.4 0.0053 16.6 1.8 2.3 2 0 0 2 2 2 2 MSP1 EGF domain 1 hEGF PF12661.5 MSTRG.18665.1_2 - 1e-05 25.9 24.6 0.0014 19.1 8.0 3.0 3 0 0 3 3 3 2 Human growth factor-like EGF EGF_2 PF07974.11 MSTRG.18665.1_2 - 0.00068 19.8 20.5 0.001 19.3 9.4 2.5 2 0 0 2 2 2 2 EGF-like domain SR-25 PF10500.7 MSTRG.19398.2_2 - 0.0025 17.3 50.8 0.0025 17.3 50.8 2.1 1 1 1 2 2 2 1 Nuclear RNA-splicing-associated protein DUF547 PF04784.12 MSTRG.22917.3_2 - 5.7e-35 119.6 0.0 1.5e-34 118.2 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function, DUF547 DEP PF00610.19 MSTRG.22917.3_2 - 0.0048 16.8 0.1 0.013 15.4 0.0 1.8 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Glutaredoxin PF00462.22 MSTRG.22917.3_3 - 3.7e-16 59.0 0.1 6.3e-16 58.2 0.1 1.4 1 0 0 1 1 1 1 Glutaredoxin DUF836 PF05768.12 MSTRG.22917.3_3 - 0.013 15.8 0.0 0.022 15.0 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) zf-H2C2_2 PF13465.4 MSTRG.14705.1_2 - 8e-16 57.5 27.2 4.8e-06 26.6 3.8 5.7 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.14705.1_2 - 2.3e-12 46.5 39.9 2e-05 24.6 0.4 5.6 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.14705.1_2 - 4.8e-08 33.0 37.8 0.00016 22.0 0.5 5.7 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_11 PF16622.3 MSTRG.14705.1_2 - 0.0071 15.9 0.3 0.0071 15.9 0.3 4.1 5 0 0 5 5 5 1 zinc-finger C2H2-type zf-H2C2_5 PF13909.4 MSTRG.14705.1_2 - 0.0078 15.8 0.1 0.0078 15.8 0.1 5.2 5 0 0 5 5 5 2 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.4 MSTRG.14705.1_2 - 0.035 13.9 33.3 0.17 11.7 5.4 5.3 5 0 0 5 5 5 0 C2H2-type zinc finger Gla PF00594.18 MSTRG.16317.1_1 - 6.6e-19 67.7 6.6 1.1e-18 67.0 6.6 1.4 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain SARAF PF06682.10 MSTRG.16317.1_1 - 0.078 12.5 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis WBP-1 PF11669.6 MSTRG.16317.1_1 - 0.11 13.0 1.0 0.8 10.2 0.0 2.5 2 1 0 2 2 2 0 WW domain-binding protein 1 NIF PF03031.16 MSTRG.5839.1_3 - 2.3e-54 183.3 1.0 3.6e-54 182.6 1.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Vg_Tdu PF07545.12 MSTRG.3373.1_1 - 9.2e-12 44.3 0.1 1.7e-11 43.5 0.1 1.4 1 0 0 1 1 1 1 Vestigial/Tondu family p450 PF00067.20 MSTRG.27649.1_2 - 1.3e-87 294.4 0.0 1.9e-87 293.8 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 FAD_binding_7 PF03441.12 MSTRG.5775.2_1 - 2.2e-67 226.1 0.8 3.1e-67 225.7 0.8 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.16 MSTRG.5775.2_2 - 3.7e-45 153.7 0.0 6.8e-45 152.9 0.0 1.4 1 0 0 1 1 1 1 DNA photolyase PI-PLC-X PF00388.17 MSTRG.6560.1_3 - 2.4e-63 211.9 0.0 4e-63 211.2 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain SH2 PF00017.22 MSTRG.6560.1_3 - 2.6e-43 145.8 0.1 2.5e-22 78.6 0.0 2.7 2 0 0 2 2 2 2 SH2 domain PI-PLC-Y PF00387.17 MSTRG.6560.1_3 - 3.1e-38 130.6 0.0 7.8e-38 129.3 0.0 1.8 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 PF00018.26 MSTRG.6560.1_3 - 6.9e-15 54.3 0.4 1.7e-14 53.0 0.4 1.7 1 0 0 1 1 1 1 SH3 domain PH PF00169.27 MSTRG.6560.1_3 - 1.3e-14 54.5 0.2 7.4e-05 23.1 0.0 3.7 3 0 0 3 3 3 3 PH domain C2 PF00168.28 MSTRG.6560.1_3 - 3.7e-11 43.1 0.0 7.4e-11 42.1 0.0 1.5 1 0 0 1 1 1 1 C2 domain SH3_9 PF14604.4 MSTRG.6560.1_3 - 9.6e-10 38.0 0.1 2.1e-09 37.0 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH_12 PF16457.3 MSTRG.6560.1_3 - 3e-06 27.6 0.4 0.00032 21.1 0.0 3.5 4 0 0 4 4 4 1 Pleckstrin homology domain SH3_2 PF07653.15 MSTRG.6560.1_3 - 7.9e-06 25.3 0.0 2e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain GDPD PF03009.15 MSTRG.6560.1_3 - 0.016 14.8 0.0 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family Acetyltransf_10 PF13673.5 MSTRG.28518.1_3 - 0.055 13.3 0.0 0.067 13.0 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain VKOR PF07884.12 MSTRG.2758.1_3 - 3.2e-29 101.5 11.1 6.6e-29 100.5 11.1 1.6 1 0 0 1 1 1 1 Vitamin K epoxide reductase family Gln-synt_C PF00120.22 MSTRG.8492.1_2 - 1.4e-16 60.4 0.0 1.3e-12 47.3 0.0 2.2 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.17 MSTRG.8492.1_2 - 2.7e-12 46.1 0.0 5.1e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Nebulin PF00880.16 MSTRG.15447.1_3 - 1.3e-181 587.2 190.4 6e-11 41.9 0.7 43.7 44 0 0 44 44 44 42 Nebulin repeat LIM PF00412.20 MSTRG.15447.1_3 - 5.6e-09 36.0 8.3 1.4e-08 34.7 8.3 1.7 1 0 0 1 1 1 1 LIM domain IF2_N PF04760.13 MSTRG.15447.1_3 - 0.032 13.9 0.6 11 5.8 0.0 4.2 4 0 0 4 4 4 0 Translation initiation factor IF-2, N-terminal region Spc97_Spc98 PF04130.11 MSTRG.23999.1_2 - 3.4e-132 441.9 9.1 5.8e-132 441.1 9.1 1.4 1 1 0 1 1 1 1 Spc97 / Spc98 family GD_AH_C PF04295.11 MSTRG.23999.1_2 - 0.12 11.0 0.0 0.19 10.4 0.0 1.2 1 0 0 1 1 1 0 D-galactarate dehydratase / Altronate hydrolase, C terminus Mito_carr PF00153.25 MSTRG.3824.1_3 - 2.3e-66 219.6 3.9 1.1e-23 82.8 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein OAF PF14941.4 MSTRG.18075.1_3 - 8.8e-110 365.7 0.2 1.2e-109 365.3 0.2 1.2 1 0 0 1 1 1 1 Transcriptional regulator, Out at first Collectrin PF16959.3 MSTRG.12402.1_3 - 3.7e-61 205.2 0.0 5.3e-61 204.7 0.0 1.2 1 0 0 1 1 1 1 Renal amino acid transporter DUF1191 PF06697.10 MSTRG.12402.1_3 - 0.038 13.1 0.0 0.058 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) VHS PF00790.17 MSTRG.14216.2_2 - 1.4e-45 154.5 0.0 3.6e-45 153.2 0.0 1.7 2 0 0 2 2 2 1 VHS domain GAT PF03127.12 MSTRG.14216.2_2 - 6.5e-27 93.5 2.1 1.3e-26 92.6 2.1 1.5 1 0 0 1 1 1 1 GAT domain ENTH PF01417.18 MSTRG.14216.2_2 - 0.045 13.7 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 ENTH domain HLH PF00010.24 MSTRG.7616.1_1 - 4.8e-15 55.1 0.4 7.5e-15 54.5 0.4 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain IncA PF04156.12 MSTRG.7616.1_1 - 0.0029 17.3 0.2 0.0047 16.6 0.2 1.3 1 0 0 1 1 1 1 IncA protein JAKMIP_CC3 PF16034.3 MSTRG.7616.1_1 - 0.017 14.9 2.3 0.025 14.4 2.3 1.3 1 0 0 1 1 1 0 JAKMIP CC3 domain SlyX PF04102.10 MSTRG.7616.1_1 - 0.025 15.1 2.2 0.062 13.8 2.2 1.6 1 0 0 1 1 1 0 SlyX bZIP_2 PF07716.13 MSTRG.7616.1_1 - 0.033 14.1 2.7 0.086 12.8 2.7 1.7 1 0 0 1 1 1 0 Basic region leucine zipper DivIC PF04977.13 MSTRG.7616.1_1 - 0.45 10.2 2.7 0.94 9.2 2.7 1.5 1 0 0 1 1 1 0 Septum formation initiator tRNA-synt_2 PF00152.18 MSTRG.17367.1_3 - 5.7e-79 265.3 0.0 8.1e-79 264.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.23 MSTRG.17367.1_3 - 6e-12 45.3 0.0 1.6e-11 43.9 0.0 1.8 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.18 MSTRG.17367.1_3 - 6.4e-07 29.0 0.0 0.022 14.1 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) Kunitz_BPTI PF00014.21 MSTRG.14022.1_1 - 1e-19 70.4 2.1 1.7e-19 69.7 2.1 1.4 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Ribosomal_L30 PF00327.18 MSTRG.16497.1_1 - 3.5e-16 58.7 1.1 8e-16 57.6 0.3 2.1 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.10 MSTRG.16497.1_1 - 1.5e-10 41.0 4.4 1.5e-10 41.0 4.4 1.8 2 0 0 2 2 2 1 Ribosomal L30 N-terminal domain PRIMA1 PF16101.3 MSTRG.16497.1_1 - 2.4 8.1 11.2 0.1 12.5 3.5 2.4 3 0 0 3 3 3 0 Proline-rich membrane anchor 1 CAP_N PF01213.17 MSTRG.16497.1_1 - 7.5 5.8 8.4 16 4.7 8.4 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Calreticulin PF00262.16 MSTRG.1777.1_2 - 6e-82 275.3 6.1 3.6e-59 200.4 0.6 2.3 1 1 1 2 2 2 2 Calreticulin family Pkinase PF00069.23 MSTRG.16391.1_1 - 6.4e-15 55.1 0.0 1.1e-14 54.3 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.16391.1_1 - 0.0041 16.3 0.0 0.0079 15.4 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.16391.1_1 - 0.018 14.2 0.0 0.36 9.9 0.0 2.1 2 0 0 2 2 2 0 Kinase-like APH PF01636.21 MSTRG.16391.1_1 - 0.07 12.9 4.2 1.1 9.0 0.2 2.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.12 MSTRG.16391.1_1 - 0.14 11.3 0.1 0.55 9.4 0.0 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.14 MSTRG.16391.1_1 - 0.21 11.7 0.0 0.35 10.9 0.0 1.3 1 0 0 1 1 1 0 ABC1 family SelP_N PF04592.12 MSTRG.7018.1_2 - 1.4e-71 240.5 3.4 2e-71 240.0 3.4 1.1 1 0 0 1 1 1 1 Selenoprotein P, N terminal region Kinesin PF00225.21 MSTRG.10217.1_3 - 4.1e-92 308.5 0.0 1.2e-91 307.0 0.0 1.8 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 MSTRG.10217.1_3 - 4.6e-16 59.0 0.0 2.4e-13 50.1 0.0 2.8 2 0 0 2 2 2 2 Microtubule binding CNH PF00780.20 MSTRG.8939.3_3 - 2.7e-71 240.3 0.2 3.5e-71 239.9 0.2 1.1 1 0 0 1 1 1 1 CNH domain Lentiviral_Tat PF02998.12 MSTRG.29063.1_1 - 0.056 13.4 0.1 0.082 12.8 0.1 1.3 1 0 0 1 1 1 0 Lentiviral Tat protein DUF4448 PF14610.4 MSTRG.29063.1_1 - 0.19 11.3 0.0 0.26 10.9 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) DUF4118 PF13493.4 MSTRG.29063.1_1 - 0.9 9.2 7.0 0.23 11.1 3.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4118) Neurensin PF14927.4 MSTRG.29063.1_2 - 0.13 11.8 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Neurensin DUF3395 PF11875.6 MSTRG.13809.1_1 - 1.2e-30 106.3 0.0 1.8e-30 105.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) EGF_2 PF07974.11 MSTRG.29169.1_3 - 0.0027 17.9 14.3 0.0027 17.9 14.3 4.3 2 2 1 3 3 3 1 EGF-like domain CFC PF09443.8 MSTRG.20952.3_2 - 2.4e-16 59.1 14.9 3.1e-16 58.8 10.3 2.8 2 0 0 2 2 2 1 Cripto_Frl-1_Cryptic (CFC) zf-B_box PF00643.22 MSTRG.12041.2_1 - 0.00028 20.9 6.9 0.00028 20.9 6.9 3.1 3 0 0 3 3 3 1 B-box zinc finger SHE3 PF17078.3 MSTRG.12041.2_1 - 0.0058 16.2 0.7 0.0082 15.7 0.7 1.2 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 ATG16 PF08614.9 MSTRG.12041.2_1 - 0.0082 16.2 1.2 0.013 15.6 1.2 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) IF-2B PF01008.15 MSTRG.12041.2_1 - 0.1 11.6 0.5 0.15 11.1 0.5 1.2 1 0 0 1 1 1 0 Initiation factor 2 subunit family Mod_r PF07200.11 MSTRG.12041.2_1 - 0.11 12.5 4.1 0.17 11.8 4.1 1.2 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Med4 PF10018.7 MSTRG.12041.2_1 - 0.23 11.0 1.3 0.34 10.4 1.3 1.1 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 BssS PF13991.4 MSTRG.12041.2_1 - 0.63 10.0 2.3 1.9 8.5 0.6 2.1 2 0 0 2 2 2 0 BssS protein family DUF1664 PF07889.10 MSTRG.12041.2_1 - 0.68 9.8 2.9 1.3 8.9 2.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Spc7 PF08317.9 MSTRG.12041.2_1 - 0.75 8.5 6.6 1 8.0 6.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Pheromone PF08015.9 MSTRG.21495.1_2 - 0.072 14.0 0.6 0.17 12.8 0.0 1.8 2 0 0 2 2 2 0 Fungal mating-type pheromone Connexin PF00029.17 MSTRG.15033.1_2 - 2.1e-94 315.4 2.9 3.1e-94 314.9 2.9 1.2 1 0 0 1 1 1 1 Connexin YdjC PF04794.10 MSTRG.26939.2_1 - 5.9e-61 206.3 0.1 7.5e-61 206.0 0.1 1.1 1 0 0 1 1 1 1 YdjC-like protein 7tm_2 PF00002.22 MSTRG.18664.1_2 - 2.9e-18 66.0 8.9 4.5e-18 65.3 8.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.19 MSTRG.18664.1_2 - 3.2e-06 27.6 1.3 6.8e-06 26.5 1.3 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif DUF3278 PF11683.6 MSTRG.18664.1_2 - 0.0044 17.0 0.7 0.0063 16.5 0.1 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3278) DUF2157 PF09925.7 MSTRG.18664.1_2 - 0.0097 15.6 4.1 0.016 14.9 4.1 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2157) EI24 PF07264.9 MSTRG.18664.1_2 - 0.038 14.1 6.8 0.054 13.6 6.8 1.3 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) DUF2231 PF09990.7 MSTRG.18664.1_2 - 0.19 12.0 4.6 0.41 11.0 4.6 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2231) Frizzled PF01534.15 MSTRG.18664.1_2 - 0.4 9.6 6.0 0.87 8.5 5.4 1.8 1 1 1 2 2 2 0 Frizzled/Smoothened family membrane region DUF202 PF02656.13 MSTRG.18664.1_2 - 0.56 10.6 0.0 0.56 10.6 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF202) MgtE PF01769.14 MSTRG.18664.1_2 - 2.7 8.3 6.8 10 6.4 0.5 2.1 1 1 1 2 2 2 0 Divalent cation transporter DUF4366 PF14283.4 MSTRG.17308.1_1 - 0.00087 18.7 0.2 0.0025 17.2 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) YtxH PF12732.5 MSTRG.17308.1_1 - 0.025 15.0 1.5 0.025 15.0 1.5 2.5 2 0 0 2 2 2 0 YtxH-like protein Pox_A_type_inc PF04508.10 MSTRG.17308.1_1 - 0.46 10.3 12.8 0.4 10.5 2.0 2.8 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat PDZ PF00595.22 MSTRG.18455.2_3 - 8.1e-15 54.8 0.0 1.3e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.18455.2_3 - 0.0021 18.2 0.0 0.0057 16.8 0.0 1.6 2 0 0 2 2 2 1 PDZ domain DUF1156 PF06634.10 MSTRG.26655.3_1 - 0.55 10.3 4.6 1.3 9.1 4.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1156) Rep_fac_C PF08542.9 MSTRG.26655.3_3 - 1.9e-25 88.9 0.0 4.2e-25 87.8 0.0 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.27 MSTRG.26655.3_3 - 2.7e-12 47.1 0.1 3.9e-12 46.6 0.1 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.4 MSTRG.26655.3_3 - 2.8e-09 36.8 0.1 7.7e-09 35.4 0.2 1.5 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_14 PF13173.4 MSTRG.26655.3_3 - 0.0002 21.3 0.0 0.00038 20.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.4 MSTRG.26655.3_3 - 0.00083 19.5 0.1 0.17 12.0 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.3 MSTRG.26655.3_3 - 0.00086 19.4 0.0 0.0017 18.5 0.0 1.5 1 0 0 1 1 1 1 AAA C-terminal domain Viral_helicase1 PF01443.16 MSTRG.26655.3_3 - 0.0029 17.2 0.0 0.0051 16.4 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase MipZ PF09140.9 MSTRG.26655.3_3 - 0.0058 15.8 0.0 0.0087 15.2 0.0 1.2 1 0 0 1 1 1 1 ATPase MipZ AAA_11 PF13086.4 MSTRG.26655.3_3 - 0.0065 16.1 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 MSTRG.26655.3_3 - 0.027 14.7 0.1 1.2 9.3 0.0 2.2 1 1 1 2 2 2 0 AAA ATPase domain AAA_24 PF13479.4 MSTRG.26655.3_3 - 0.039 13.6 0.0 0.07 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.4 MSTRG.26655.3_3 - 0.044 13.4 0.0 0.078 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain DEAD PF00270.27 MSTRG.26655.3_3 - 0.067 12.8 0.4 0.52 9.9 0.2 2.3 1 1 2 3 3 3 0 DEAD/DEAH box helicase AAA_19 PF13245.4 MSTRG.26655.3_3 - 0.13 12.4 0.1 0.35 11.0 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.12 MSTRG.26655.3_3 - 0.14 12.0 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) SCAMP PF04144.11 MSTRG.9247.1_3 - 1.3e-70 237.1 13.2 1.9e-70 236.6 13.2 1.2 1 0 0 1 1 1 1 SCAMP family NPF PF16601.3 MSTRG.9247.1_3 - 0.18 12.1 6.0 0.46 10.8 6.0 1.5 1 1 0 1 1 1 0 Rabosyn-5 repeating NPF sequence-motif NAD_kinase PF01513.19 MSTRG.15318.2_3 - 0.054 12.5 0.1 0.098 11.7 0.1 1.3 1 0 0 1 1 1 0 ATP-NAD kinase nlz1 PF12402.6 MSTRG.4016.1_3 - 2.9e-16 59.5 9.7 2.9e-16 59.5 9.7 3.5 3 0 0 3 3 3 1 NocA-like zinc-finger protein 1 zf-C2H2 PF00096.24 MSTRG.4016.1_3 - 0.0037 17.5 1.5 0.013 15.8 0.3 2.7 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.4016.1_3 - 0.032 14.4 0.0 0.077 13.2 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.4 MSTRG.4016.1_3 - 0.043 14.5 0.1 0.043 14.5 0.1 2.8 3 0 0 3 3 3 0 C2H2-type zinc finger YdaT_toxin PF06254.9 MSTRG.519.1_3 - 0.1 12.8 0.1 0.16 12.2 0.1 1.2 1 0 0 1 1 1 0 Putative bacterial toxin ydaT LNS2 PF08235.11 MSTRG.13778.1_1 - 3e-105 350.6 0.0 4.5e-105 350.0 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_mid PF16876.3 MSTRG.13778.1_1 - 1e-18 67.2 0.8 4e-18 65.4 0.8 1.9 2 0 0 2 2 2 1 Lipin/Ned1/Smp2 multi-domain protein middle domain WRNPLPNID PF15017.4 MSTRG.13778.1_1 - 0.00083 20.1 0.1 0.0017 19.1 0.1 1.5 1 0 0 1 1 1 1 Putative WW-binding domain and destruction box Lipin_mid PF16876.3 MSTRG.13778.1_2 - 1.7e-06 28.0 0.2 3.2e-06 27.1 0.2 1.4 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain Sushi PF00084.18 MSTRG.1763.3_3 - 3.3e-56 187.6 72.1 8.7e-10 39.0 0.7 12.3 11 1 1 12 12 12 11 Sushi repeat (SCR repeat) DUF3915 PF13054.4 MSTRG.25424.1_1 - 9.9 6.0 12.0 0.63 9.9 3.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) Homeobox PF00046.27 MSTRG.25424.1_2 - 5.3e-18 64.4 7.3 1.2e-17 63.3 7.3 1.6 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 MSTRG.25424.1_2 - 0.048 13.4 1.1 0.17 11.7 1.1 2.0 1 0 0 1 1 1 0 Homeobox KN domain Homez PF11569.6 MSTRG.25424.1_2 - 3.6 7.0 6.0 0.2 11.0 0.3 1.9 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez zf-C2H2 PF00096.24 MSTRG.9979.1_3 - 8.6e-26 88.8 57.0 6.7e-06 26.1 0.2 8.9 9 0 0 9 9 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.9979.1_3 - 6.9e-25 85.5 57.9 0.00071 20.1 0.2 8.8 8 0 0 8 8 8 7 C2H2-type zinc finger zf-H2C2_2 PF13465.4 MSTRG.9979.1_3 - 1e-22 79.4 52.5 1.9e-07 31.1 0.7 9.1 10 0 0 10 10 9 6 Zinc-finger double domain zf-met PF12874.5 MSTRG.9979.1_3 - 4.5e-17 61.7 44.0 0.0013 18.9 1.2 8.1 8 0 0 8 8 7 6 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.9979.1_3 - 8.8e-13 48.1 36.3 0.001 19.2 0.8 7.8 8 0 0 8 8 7 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 MSTRG.9979.1_3 - 5.1e-06 26.2 42.0 0.24 11.3 1.0 7.8 7 0 0 7 7 7 5 C2H2-type zinc finger zf-C2H2_11 PF16622.3 MSTRG.9979.1_3 - 0.016 14.8 45.8 0.21 11.3 0.1 7.9 8 0 0 8 8 7 0 zinc-finger C2H2-type DUF3268 PF11672.6 MSTRG.9979.1_3 - 0.076 13.2 0.2 0.076 13.2 0.2 4.2 5 0 0 5 5 5 0 zinc-finger-containing domain Desulfoferrod_N PF06397.10 MSTRG.9979.1_3 - 0.41 10.2 6.2 3.6 7.1 0.3 3.7 3 0 0 3 3 3 0 Desulfoferrodoxin, N-terminal domain zf-C2H2_8 PF15909.3 MSTRG.9979.1_3 - 0.81 9.9 20.3 0.37 11.0 0.7 4.2 4 1 0 4 4 3 0 C2H2-type zinc ribbon zf-C2H2_2 PF12756.5 MSTRG.9979.1_3 - 1 9.6 42.6 0.48 10.6 1.5 7.9 4 3 4 8 8 8 0 C2H2 type zinc-finger (2 copies) BolA PF01722.16 MSTRG.9979.1_3 - 2.5 8.3 4.8 34 4.7 0.0 3.4 3 0 0 3 3 3 0 BolA-like protein FYDLN_acid PF09538.8 MSTRG.9979.1_3 - 6.9 7.3 9.7 1.1e+02 3.4 0.8 5.3 5 1 0 5 5 4 0 Protein of unknown function (FYDLN_acid) UPF0697 PF15117.4 MSTRG.7448.1_1 - 5.2e-56 186.6 0.1 1.1e-55 185.7 0.1 1.5 1 0 0 1 1 1 1 Uncharacterised protein family UPF0697 Geminin PF07412.10 MSTRG.85.1_3 - 1.3e-73 246.9 10.4 1.9e-73 246.3 10.4 1.2 1 0 0 1 1 1 1 Geminin Shugoshin_N PF07558.9 MSTRG.85.1_3 - 0.14 11.9 1.9 0.3 10.9 0.6 2.3 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region DivIC PF04977.13 MSTRG.85.1_3 - 0.27 10.9 6.7 0.065 12.9 2.3 2.2 2 0 0 2 2 2 0 Septum formation initiator DUF5094 PF17015.3 MSTRG.85.1_3 - 1.9 8.4 9.5 0.36 10.8 5.4 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5094) DUF972 PF06156.11 MSTRG.85.1_3 - 1.9 9.0 7.9 0.84 10.2 4.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF972) DGF-1_C PF11040.6 MSTRG.85.1_3 - 4.1 7.3 10.6 1.5 8.7 0.0 2.9 3 0 0 3 3 3 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Prefoldin PF02996.15 MSTRG.22168.1_3 - 2.8e-14 52.9 0.1 8.9e-14 51.3 0.0 1.8 2 0 0 2 2 2 1 Prefoldin subunit Prefoldin_3 PF13758.4 MSTRG.22168.1_3 - 1.1e-09 38.1 0.0 4.5e-09 36.1 0.0 2.1 2 0 0 2 2 2 1 Prefoldin subunit DUF3835 PF12927.5 MSTRG.22168.1_3 - 0.24 12.2 0.1 0.24 12.2 0.1 2.8 4 0 0 4 4 4 0 Domain of unknown function (DUF3835) WD40 PF00400.30 MSTRG.8442.2_1 - 4.5e-27 93.6 9.3 3.9e-06 27.4 0.0 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.8442.2_1 - 7.4e-15 54.9 4.2 1.8e-06 28.0 0.2 4.2 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 MSTRG.8442.2_1 - 5.4e-05 23.0 0.1 0.78 9.4 0.0 2.9 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.3 MSTRG.8442.2_1 - 0.031 13.1 0.0 0.1 11.4 0.0 1.9 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein ELYS-bb PF16687.3 MSTRG.8442.2_1 - 0.037 12.5 0.2 0.13 10.7 0.0 1.8 2 0 0 2 2 2 0 beta-propeller of ELYS nucleoporin KxDL PF10241.7 MSTRG.18452.1_3 - 3.7e-29 100.7 0.7 3.7e-29 100.7 0.7 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein SLY PF12485.6 MSTRG.18452.1_3 - 0.025 15.2 4.3 0.03 14.9 0.1 2.2 2 0 0 2 2 2 0 Lymphocyte signaling adaptor protein Pkinase_Tyr PF07714.15 MSTRG.7729.1_1 - 1.9e-89 299.3 0.0 2.7e-89 298.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.7729.1_1 - 4e-35 121.3 0.0 6e-35 120.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ig_2 PF13895.4 MSTRG.7729.1_1 - 1.3e-15 57.3 0.4 4.9e-07 29.9 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.7729.1_1 - 2.5e-15 56.7 4.6 1.8e-07 31.5 0.1 3.2 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 MSTRG.7729.1_1 - 3.9e-14 52.3 0.0 5.6e-08 32.6 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin I-set domain fn3 PF00041.19 MSTRG.7729.1_1 - 6.3e-14 51.9 1.1 2.5e-06 27.6 0.0 3.0 3 0 0 3 3 3 2 Fibronectin type III domain ig PF00047.23 MSTRG.7729.1_1 - 8.8e-09 35.3 3.5 8.5e-08 32.1 0.1 3.1 3 1 0 3 3 3 1 Immunoglobulin domain V-set PF07686.15 MSTRG.7729.1_1 - 0.0015 18.5 0.1 0.0067 16.4 0.0 2.2 2 1 0 2 2 2 1 Immunoglobulin V-set domain C1-set PF07654.13 MSTRG.7729.1_1 - 0.0016 18.7 0.1 3.9 7.9 0.0 3.0 3 0 0 3 3 3 2 Immunoglobulin C1-set domain Izumo-Ig PF16706.3 MSTRG.7729.1_1 - 0.11 12.4 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain Ig_3 PF13927.4 MSTRG.2345.2_2 - 0.0023 18.4 0.0 0.0023 18.4 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain DUF3394 PF11874.6 MSTRG.9042.1_1 - 0.032 13.8 0.4 0.052 13.1 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3394) BTB PF00651.29 MSTRG.9042.1_3 - 2.1e-24 85.8 0.3 4.9e-24 84.5 0.3 1.7 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 MSTRG.9042.1_3 - 2.9e-15 55.7 56.4 0.0024 18.1 6.0 6.5 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.9042.1_3 - 1.4e-14 53.7 47.7 2.5e-07 30.7 5.7 7.0 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.9042.1_3 - 2.6e-14 52.6 56.5 0.004 17.7 4.2 6.7 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.9042.1_3 - 3.4e-05 23.5 40.7 0.019 14.8 1.8 6.5 6 0 0 6 6 6 3 C2H2-type zinc finger zf-met PF12874.5 MSTRG.9042.1_3 - 3.5e-05 23.9 45.5 0.029 14.6 0.1 6.5 6 0 0 6 6 6 4 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.3 MSTRG.9042.1_3 - 0.00094 19.8 17.1 0.42 11.3 1.4 3.6 2 1 1 3 3 3 3 zinc-ribbon family Zn-ribbon_8 PF09723.8 MSTRG.9042.1_3 - 0.0015 18.5 20.5 0.33 11.0 3.5 4.2 3 1 0 3 3 3 3 Zinc ribbon domain ADK_lid PF05191.12 MSTRG.9042.1_3 - 0.0093 15.8 1.7 0.0093 15.8 1.7 3.4 3 1 1 4 4 4 1 Adenylate kinase, active site lid Lactamase_B_5 PF14597.4 MSTRG.9042.1_3 - 0.012 15.0 0.2 0.021 14.2 0.2 1.3 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily zf-C2H2_2 PF12756.5 MSTRG.9042.1_3 - 0.034 14.4 1.2 0.034 14.4 1.2 7.0 3 1 5 8 8 8 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.6 MSTRG.9042.1_3 - 0.058 13.6 44.4 0.092 13.0 0.2 6.5 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding zf-AD PF07776.13 MSTRG.9042.1_3 - 0.12 12.5 0.2 0.12 12.5 0.2 4.4 5 1 1 6 6 4 0 Zinc-finger associated domain (zf-AD) zf-C2H2_11 PF16622.3 MSTRG.9042.1_3 - 7.5 6.3 25.5 0.057 13.1 0.8 5.0 6 0 0 6 6 6 0 zinc-finger C2H2-type Endosulfine PF04667.15 MSTRG.25067.1_1 - 1.9e-10 40.6 0.6 3.1e-10 39.9 0.6 1.3 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region TGS PF02824.19 MSTRG.14292.3_1 - 0.018 15.0 0.0 0.039 13.9 0.0 1.5 1 0 0 1 1 1 0 TGS domain tRNA-synt_2b PF00587.23 MSTRG.14292.3_2 - 1e-36 126.5 0.0 1.5e-36 125.9 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.18 MSTRG.14292.3_2 - 7.9e-18 64.3 0.0 1.7e-17 63.3 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain CTD_bind PF04818.11 MSTRG.14292.3_2 - 2e-17 63.6 0.5 4.5e-17 62.5 0.5 1.7 1 0 0 1 1 1 1 RNA polymerase II-binding domain. CREPT PF16566.3 MSTRG.14292.3_2 - 2.4e-07 30.9 0.0 2.4e-07 30.9 0.0 2.0 2 0 0 2 2 2 1 Cell-cycle alteration and expression-elevated protein in tumour tRNA_SAD PF07973.12 MSTRG.14292.3_2 - 0.0016 18.4 0.0 0.021 14.8 0.0 2.5 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain AIP3 PF03915.11 MSTRG.7137.4_2 - 5.9e-11 42.0 23.1 1.7e-07 30.5 0.0 4.3 4 1 0 4 4 4 3 Actin interacting protein 3 Sulfotransfer_2 PF03567.12 MSTRG.3387.1_2 - 2.1e-76 257.0 0.0 3.3e-76 256.4 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase family Gal-3-0_sulfotr PF06990.9 MSTRG.3387.1_2 - 7.5e-06 24.9 1.2 0.053 12.3 0.0 2.2 2 0 0 2 2 2 2 Galactose-3-O-sulfotransferase McrBC PF10117.7 MSTRG.3387.1_2 - 0.025 13.6 0.7 0.041 12.9 0.7 1.2 1 0 0 1 1 1 0 McrBC 5-methylcytosine restriction system component RNHCP PF12647.5 MSTRG.3387.1_3 - 0.029 14.2 0.6 0.058 13.2 0.6 1.4 1 0 0 1 1 1 0 RNHCP domain DRMBL PF07522.12 MSTRG.24225.1_3 - 4.5e-14 52.5 0.0 8.7e-14 51.6 0.0 1.5 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.5 MSTRG.24225.1_3 - 2.6e-05 23.7 0.0 6.8e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.25 MSTRG.24225.1_3 - 0.02 14.8 0.0 0.052 13.4 0.0 1.7 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily RhoGEF PF00621.18 MSTRG.22453.1_1 - 3.7e-37 128.2 0.5 8.6e-37 127.0 0.5 1.7 1 0 0 1 1 1 1 RhoGEF domain RBD PF02196.13 MSTRG.22453.1_1 - 2.4e-14 53.0 0.1 5.3e-14 51.9 0.1 1.6 1 0 0 1 1 1 1 Raf-like Ras-binding domain PH PF00169.27 MSTRG.22453.1_1 - 4.3e-09 36.7 0.1 1.5e-08 35.0 0.0 2.0 2 0 0 2 2 2 1 PH domain PDZ PF00595.22 MSTRG.22453.1_1 - 2e-07 31.2 0.0 5e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PH_9 PF15410.4 MSTRG.22453.1_1 - 1.5e-05 25.3 0.1 5.4e-05 23.4 0.0 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain PDZ_2 PF13180.4 MSTRG.22453.1_1 - 8.3e-05 22.7 0.0 0.00019 21.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain EF-hand_6 PF13405.4 MSTRG.22891.1_3 - 2.5e-08 33.1 0.1 0.0055 16.4 0.1 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.30 MSTRG.22891.1_3 - 1.9e-05 23.8 0.3 0.27 10.8 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.4 MSTRG.22891.1_3 - 0.00031 21.0 0.0 0.37 11.2 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair UPF0154 PF03672.11 MSTRG.22891.1_3 - 0.0085 16.0 0.0 0.32 10.9 0.0 2.2 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0154) EF-hand_8 PF13833.4 MSTRG.22891.1_3 - 0.022 14.4 2.9 2.7 7.7 0.1 3.9 2 2 2 4 4 4 0 EF-hand domain pair EF-hand_9 PF14658.4 MSTRG.22891.1_3 - 0.036 14.3 0.0 2.1 8.6 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain DUF3597 PF12200.6 MSTRG.22891.1_3 - 0.7 10.3 4.5 1.2 9.6 4.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) V-set PF07686.15 MSTRG.18887.1_2 - 5.1e-15 55.4 0.0 8.3e-15 54.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 MSTRG.18887.1_2 - 0.00012 22.5 0.0 0.00021 21.7 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 MSTRG.18887.1_2 - 0.036 14.1 0.0 0.081 13.0 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain Ras PF00071.20 MSTRG.3909.1_1 - 2.4e-55 186.4 0.0 3.2e-55 186.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.3909.1_1 - 6.4e-21 74.7 0.0 1e-20 74.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.3909.1_1 - 2.7e-08 33.3 0.0 3.9e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Myelin_MBP PF01669.15 MSTRG.5073.1_1 - 6e-29 101.5 9.2 7.1e-26 91.5 9.2 2.2 1 1 0 1 1 1 1 Myelin basic protein Fibrinogen_C PF00147.16 MSTRG.12679.4_3 - 1.5e-55 188.2 1.1 2.1e-55 187.8 1.1 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF16 PF01519.14 MSTRG.12679.4_3 - 1.4 9.3 8.3 6.7 7.1 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF1664 PF07889.10 MSTRG.12679.4_3 - 3.3 7.6 7.2 0.27 11.1 1.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) SlyX PF04102.10 MSTRG.12679.4_3 - 3.5 8.2 4.4 2.6 8.6 0.9 2.3 2 0 0 2 2 2 0 SlyX DUF4061 PF13270.4 MSTRG.12679.4_3 - 4.2 7.7 7.3 17 5.7 0.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4061) SMC_N PF02463.17 MSTRG.27946.2_1 - 1.5e-60 204.3 28.3 1.1e-58 198.2 28.3 3.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.11 MSTRG.27946.2_1 - 6.5e-25 87.6 0.2 6.5e-25 87.6 0.2 2.7 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.4 MSTRG.27946.2_1 - 2e-09 37.6 12.1 4.8e-05 23.2 0.8 3.4 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.4 MSTRG.27946.2_1 - 2.3e-08 34.7 28.8 2.3e-08 34.7 28.8 7.1 2 2 2 4 4 4 1 AAA domain AAA_29 PF13555.4 MSTRG.27946.2_1 - 0.00078 19.0 0.0 0.0017 17.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF3018 PF11455.6 MSTRG.27946.2_1 - 0.16 11.8 1.2 0.82 9.5 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3018) Glypican PF01153.17 MSTRG.15951.1_2 - 3.3e-87 293.5 0.0 4.5e-87 293.0 0.0 1.1 1 0 0 1 1 1 1 Glypican NlpE_C PF17185.2 MSTRG.11506.3_1 - 0.099 12.8 0.1 0.27 11.4 0.1 1.7 1 0 0 1 1 1 0 NlpE C-terminal OB domain CD225 PF04505.10 MSTRG.21681.1_1 - 1.4e-16 60.3 0.1 1.4e-16 60.3 0.1 2.1 2 0 0 2 2 2 1 Interferon-induced transmembrane protein Ost4 PF10215.7 MSTRG.21681.1_1 - 0.00029 20.5 1.4 0.00059 19.5 1.4 1.5 1 0 0 1 1 1 1 Oligosaccaryltransferase Dimer_Tnp_hAT PF05699.12 MSTRG.21681.1_1 - 0.00069 19.2 0.2 0.0012 18.4 0.2 1.4 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Pkinase_Tyr PF07714.15 MSTRG.1239.3_2 - 3.5e-102 341.0 0.0 1.1e-101 339.4 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.1239.3_2 - 8.1e-45 153.1 0.0 1.3e-44 152.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 MSTRG.1239.3_2 - 3.3e-39 132.7 0.0 8.1e-16 57.7 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.1239.3_2 - 3.1e-35 120.5 0.0 1.2e-12 48.2 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.1239.3_2 - 6.8e-26 90.3 0.0 4.5e-10 39.6 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 MSTRG.1239.3_2 - 5.5e-23 80.8 0.8 4.7e-08 33.0 0.0 3.8 4 0 0 4 4 4 3 Immunoglobulin domain V-set PF07686.15 MSTRG.1239.3_2 - 3.4e-17 62.4 0.5 5.1e-06 26.5 0.0 4.4 3 1 0 3 3 3 3 Immunoglobulin V-set domain Ig_5 PF16681.3 MSTRG.1239.3_2 - 1.1e-05 25.7 0.0 3.9 7.8 0.0 4.2 3 1 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 MSTRG.1239.3_2 - 0.0019 18.1 0.0 16 5.5 0.0 3.5 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain C2-set_2 PF08205.10 MSTRG.1239.3_2 - 0.003 17.5 1.1 0.025 14.5 0.0 2.9 4 0 0 4 4 4 1 CD80-like C2-set immunoglobulin domain Methyltransf_10 PF05971.10 MSTRG.16970.5_3 - 5.3e-123 410.0 0.0 6.6e-123 409.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF890) MTS PF05175.12 MSTRG.16970.5_3 - 0.00044 19.7 0.0 0.00077 18.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.11 MSTRG.16970.5_3 - 0.002 17.4 0.0 0.003 16.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) adh_short_C2 PF13561.4 MSTRG.18140.2_1 - 5.7e-52 176.5 0.1 8.5e-52 175.9 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.23 MSTRG.18140.2_1 - 3.9e-47 160.1 0.1 5.3e-47 159.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.8 MSTRG.18140.2_1 - 7.4e-08 32.4 0.1 1.3e-07 31.6 0.1 1.3 1 0 0 1 1 1 1 KR domain F420_oxidored PF03807.15 MSTRG.18140.2_1 - 0.018 15.4 0.0 0.033 14.6 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.16 MSTRG.18140.2_1 - 0.028 14.2 0.3 0.048 13.4 0.0 1.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TraG_N PF07916.9 MSTRG.6634.1_3 - 0.4 9.3 2.0 0.49 9.0 2.0 1.0 1 0 0 1 1 1 0 TraG-like protein, N-terminal region CCDC24 PF15669.3 MSTRG.22427.1_3 - 0.048 13.4 0.0 1.7 8.3 0.0 2.4 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 24 family DUF3585 PF12130.6 MSTRG.12353.1_2 - 9.7e-39 132.5 24.6 9.7e-39 132.5 24.6 2.6 2 0 0 2 2 1 1 Protein of unknown function (DUF3585) CH PF00307.29 MSTRG.12353.1_2 - 3.2e-20 72.2 0.0 1.2e-19 70.4 0.0 2.0 2 0 0 2 2 2 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 MSTRG.12353.1_2 - 8.5e-09 35.0 0.0 2.2e-08 33.7 0.0 1.7 1 0 0 1 1 1 1 CAMSAP CH domain LIM PF00412.20 MSTRG.12353.1_2 - 1.7e-07 31.2 11.5 3.8e-07 30.1 11.5 1.6 1 0 0 1 1 1 1 LIM domain FAD_binding_3 PF01494.17 MSTRG.12353.1_2 - 5.4e-07 29.1 0.0 2e-06 27.2 0.0 2.0 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.12 MSTRG.12353.1_2 - 4.2e-06 26.1 0.0 9e-06 25.0 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 MSTRG.12353.1_2 - 1.4e-05 24.4 0.0 3.1e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.25 MSTRG.12353.1_2 - 0.00022 21.6 0.1 0.0009 19.6 0.1 2.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.4 MSTRG.12353.1_2 - 0.00022 21.5 0.0 0.00091 19.5 0.0 2.0 1 0 0 1 1 1 1 Putative NAD(P)-binding NAD_binding_8 PF13450.4 MSTRG.12353.1_2 - 0.00045 20.3 0.2 0.0021 18.2 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 MSTRG.12353.1_2 - 0.00058 19.4 0.0 0.0011 18.5 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.22 MSTRG.12353.1_2 - 0.00086 18.4 0.6 0.0015 17.6 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.12 MSTRG.12353.1_2 - 0.0013 17.4 1.7 0.0013 17.4 0.0 1.9 2 0 0 2 2 2 1 HI0933-like protein Lycopene_cycl PF05834.10 MSTRG.12353.1_2 - 0.014 14.3 0.0 0.028 13.4 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.15 MSTRG.12353.1_2 - 0.095 11.8 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.20 MSTRG.12353.1_2 - 0.11 11.5 0.9 0.15 10.9 0.0 1.7 2 0 0 2 2 2 0 Glucose inhibited division protein A LON_substr_bdg PF02190.14 MSTRG.11429.1_3 - 1.1e-21 77.6 0.0 1.9e-21 76.7 0.0 1.4 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain zf-C3HC4_2 PF13923.4 MSTRG.11429.1_3 - 2.6e-12 46.2 35.5 3.2e-09 36.4 14.6 3.1 3 0 0 3 3 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 MSTRG.11429.1_3 - 1e-11 44.6 27.3 4.1e-07 29.9 7.9 3.5 2 1 0 2 2 2 2 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 MSTRG.11429.1_3 - 1.5e-11 43.8 24.0 3.4e-08 33.1 9.4 3.0 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.11429.1_3 - 5.7e-09 35.7 34.6 2.2e-05 24.3 12.3 4.0 3 2 0 3 3 2 2 RING-type zinc-finger zf-C3HC4 PF00097.23 MSTRG.11429.1_3 - 6.1e-09 35.5 30.8 2.3e-05 24.1 13.8 3.1 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.11429.1_3 - 1.3e-07 31.6 31.5 1.3e-05 25.2 13.6 3.2 2 0 0 2 2 2 2 Ring finger domain TPR_1 PF00515.26 MSTRG.11429.1_3 - 2.7e-07 30.0 0.3 0.048 13.4 0.2 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat Prok-RING_4 PF14447.4 MSTRG.11429.1_3 - 3e-07 30.1 28.8 0.00023 20.8 9.8 3.6 3 0 0 3 3 3 2 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 MSTRG.11429.1_3 - 1.4e-06 28.1 37.8 0.00021 21.0 12.5 3.2 3 0 0 3 3 2 2 zinc-RING finger domain TPR_2 PF07719.15 MSTRG.11429.1_3 - 5.1e-05 22.9 1.1 0.32 11.1 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat zf-RING_10 PF16685.3 MSTRG.11429.1_3 - 0.00012 22.0 26.0 0.0025 17.8 10.5 3.0 2 0 0 2 2 2 2 zinc RING finger of MSL2 TPR_16 PF13432.4 MSTRG.11429.1_3 - 0.00022 21.7 1.6 0.019 15.5 0.2 2.8 3 0 0 3 3 2 1 Tetratricopeptide repeat zf-RING_6 PF14835.4 MSTRG.11429.1_3 - 0.00082 19.1 23.0 0.005 16.6 4.1 2.9 3 0 0 3 3 2 2 zf-RING of BARD1-type protein TPR_8 PF13181.4 MSTRG.11429.1_3 - 0.0016 18.4 1.9 0.62 10.3 0.0 3.6 4 0 0 4 4 3 1 Tetratricopeptide repeat U-box PF04564.13 MSTRG.11429.1_3 - 0.012 15.6 0.0 0.06 13.4 0.0 2.2 2 0 0 2 2 1 0 U-box domain ANAPC3 PF12895.5 MSTRG.11429.1_3 - 0.042 13.9 1.0 2.3 8.4 0.6 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.4 MSTRG.11429.1_3 - 0.082 13.1 0.2 6.7 6.9 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-rbx1 PF12678.5 MSTRG.11429.1_3 - 0.17 12.1 22.8 0.028 14.6 6.8 2.9 2 0 0 2 2 2 0 RING-H2 zinc finger domain TPR_14 PF13428.4 MSTRG.11429.1_3 - 0.21 12.4 1.0 46 5.1 0.0 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.4 MSTRG.11429.1_3 - 0.23 11.5 1.3 0.62 10.1 1.1 1.8 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.11429.1_3 - 0.97 9.9 4.3 1.5 9.2 0.4 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Pkinase PF00069.23 MSTRG.17299.1_3 - 1e-08 34.7 0.0 4.5e-08 32.6 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain zinc_ribbon_2 PF13240.4 MSTRG.17299.1_3 - 6.3e-08 32.0 5.5 1.4e-07 30.8 5.5 1.7 1 0 0 1 1 1 1 zinc-ribbon domain zf-ribbon_3 PF13248.4 MSTRG.17299.1_3 - 3.5e-07 29.3 1.9 8.6e-07 28.0 1.9 1.6 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.5 MSTRG.17299.1_3 - 1.1e-05 25.2 2.5 2.3e-05 24.2 2.5 1.5 1 0 0 1 1 1 1 Double zinc ribbon Pkinase_Tyr PF07714.15 MSTRG.17299.1_3 - 4.2e-05 22.8 0.0 8.4e-05 21.8 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase zinc_ribbon_15 PF17032.3 MSTRG.17299.1_3 - 0.00013 22.5 0.4 0.00027 21.5 0.4 1.5 1 0 0 1 1 1 1 zinc-ribbon family Nudix_N_2 PF14803.4 MSTRG.17299.1_3 - 0.016 15.0 7.0 0.33 10.8 0.6 2.6 2 0 0 2 2 2 0 Nudix N-terminal zf-NADH-PPase PF09297.9 MSTRG.17299.1_3 - 0.11 12.0 10.8 0.083 12.4 1.2 2.7 3 0 0 3 3 3 0 NADH pyrophosphatase zinc ribbon domain zf-RRN7 PF11781.6 MSTRG.17299.1_3 - 0.31 10.6 1.7 4.3 7.0 1.5 2.3 1 1 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 UPF0547 PF10571.7 MSTRG.17299.1_3 - 0.32 11.0 7.3 0.28 11.2 4.9 2.2 1 1 1 2 2 2 0 Uncharacterised protein family UPF0547 GFA PF04828.12 MSTRG.17299.1_3 - 0.4 10.9 4.3 31 4.8 4.3 2.5 1 1 0 1 1 1 0 Glutathione-dependent formaldehyde-activating enzyme zf-C3HC4_3 PF13920.4 MSTRG.17299.1_3 - 0.58 9.9 2.3 1.2 8.9 2.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-dskA_traR PF01258.15 MSTRG.17299.1_3 - 1.4 8.8 5.3 2.7 7.8 0.3 2.5 2 1 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger zf-tcix PF14952.4 MSTRG.17299.1_3 - 4.1 7.0 5.2 25 4.4 0.8 2.4 1 1 1 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding NOB1_Zn_bind PF08772.9 MSTRG.17299.1_3 - 5.4 7.1 8.3 8.6 6.5 0.8 2.5 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like RNA_POL_M_15KD PF02150.14 MSTRG.17299.1_3 - 7.5 6.4 8.9 20 5.0 0.8 2.6 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit ArfGap PF01412.16 MSTRG.5975.2_1 - 2.1e-31 108.2 0.9 2.1e-31 108.2 0.9 2.7 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf bZIP_1 PF00170.19 MSTRG.21486.6_2 - 0.0095 15.9 3.8 0.0095 15.9 3.8 2.8 3 1 0 3 3 3 1 bZIP transcription factor TPR_MLP1_2 PF07926.10 MSTRG.21486.6_2 - 0.71 9.8 33.9 0.35 10.8 22.6 2.9 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Reo_sigmaC PF04582.10 MSTRG.21486.6_2 - 5.1 6.3 5.0 11 5.1 2.8 2.0 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Spc7 PF08317.9 MSTRG.21486.6_2 - 9.8 4.8 33.7 0.55 8.9 18.1 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein RabGAP-TBC PF00566.16 MSTRG.21486.6_3 - 3.5e-54 183.6 2.7 3.5e-54 183.6 2.7 1.6 2 0 0 2 2 2 1 Rab-GTPase-TBC domain DUF724 PF05266.12 MSTRG.21486.6_3 - 0.55 9.9 18.1 0.07 12.8 2.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF724) IncA PF04156.12 MSTRG.21486.6_3 - 2.2 7.9 15.4 2.4 7.8 0.3 2.4 2 0 0 2 2 2 0 IncA protein APG6 PF04111.10 MSTRG.21486.6_3 - 2.5 7.3 16.6 0.93 8.7 4.1 2.3 2 0 0 2 2 2 0 Autophagy protein Apg6 bZIP_2 PF07716.13 MSTRG.21486.6_3 - 7.9 6.5 18.0 0.38 10.7 7.2 3.1 2 0 0 2 2 2 0 Basic region leucine zipper 3Beta_HSD PF01073.17 MSTRG.2521.2_3 - 6.1e-90 300.9 0.0 7.9e-90 300.5 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 MSTRG.2521.2_3 - 5.1e-23 81.7 0.0 6.8e-23 81.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.10 MSTRG.2521.2_3 - 4e-13 49.0 0.6 1e-12 47.7 0.6 1.6 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.3 MSTRG.2521.2_3 - 7.6e-13 48.4 0.0 1e-12 48.0 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.13 MSTRG.2521.2_3 - 1.9e-09 36.9 0.1 4.4e-09 35.8 0.1 1.5 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.4 MSTRG.2521.2_3 - 3.5e-09 36.7 0.0 4.8e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.15 MSTRG.2521.2_3 - 1.5e-08 33.9 0.0 2.5e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.8 MSTRG.2521.2_3 - 4.2e-06 26.7 0.2 1.1e-05 25.3 0.2 1.6 1 1 0 1 1 1 1 KR domain NmrA PF05368.11 MSTRG.2521.2_3 - 4.5e-05 23.0 0.1 6.4e-05 22.5 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family Sacchrp_dh_NADP PF03435.16 MSTRG.2521.2_3 - 0.00059 20.0 0.6 0.012 15.7 0.6 2.2 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain adh_short PF00106.23 MSTRG.2521.2_3 - 0.0063 15.9 0.1 0.011 15.0 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase Ank_2 PF12796.5 MSTRG.10948.1_2 - 1.5e-24 86.2 5.4 7.6e-09 35.9 0.2 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) KN_motif PF12075.6 MSTRG.10948.1_2 - 1.6e-22 78.8 0.8 2.9e-22 78.0 0.8 1.4 1 0 0 1 1 1 1 KN motif Ank_5 PF13857.4 MSTRG.10948.1_2 - 2.6e-21 75.2 3.6 3.1e-12 46.4 0.1 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.10948.1_2 - 5e-18 63.2 3.9 3.7e-05 23.7 0.0 4.9 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.4 MSTRG.10948.1_2 - 1.9e-17 63.2 5.6 3.1e-08 33.9 0.1 4.5 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.10948.1_2 - 4.3e-16 58.4 10.1 0.00032 20.9 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat K-box PF01486.15 MSTRG.10948.1_2 - 2.1 8.5 5.1 0.82 9.8 1.0 2.2 2 0 0 2 2 2 0 K-box region UPF0449 PF15136.4 MSTRG.24348.2_1 - 1.5e-21 76.6 0.0 2.6e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised protein family UPF0449 YdiH PF15930.3 MSTRG.17917.2_3 - 0.001 19.0 0.1 0.21 11.6 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function K1377 PF15352.4 MSTRG.17917.2_3 - 9.8 4.2 11.1 3 5.8 1.9 2.0 2 0 0 2 2 2 0 Susceptibility to monomelic amyotrophy TPR_19 PF14559.4 MSTRG.21378.2_2 - 1.8e-11 44.3 4.2 4.4e-07 30.2 0.4 3.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.21378.2_2 - 6e-11 42.1 5.7 0.0016 18.9 0.1 4.7 1 1 4 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.21378.2_2 - 9.3e-11 40.9 8.3 0.0033 17.3 0.1 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat NARP1 PF12569.6 MSTRG.21378.2_2 - 1.6e-07 30.5 3.2 0.0013 17.6 0.7 2.1 1 1 1 2 2 2 2 NMDA receptor-regulated protein 1 TPR_16 PF13432.4 MSTRG.21378.2_2 - 2.5e-06 27.9 2.2 0.012 16.2 0.2 3.3 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.21378.2_2 - 0.00018 21.3 3.2 0.26 11.5 0.1 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.21378.2_2 - 0.0019 18.6 0.7 0.96 10.1 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.4 MSTRG.21378.2_2 - 0.012 15.9 0.4 3.5 8.0 0.1 2.3 1 1 1 2 2 2 0 Alkyl sulfatase dimerisation Wzy_C_2 PF11846.6 MSTRG.21378.2_2 - 0.045 13.5 0.1 6.4 6.5 0.1 2.3 2 0 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal TPR_17 PF13431.4 MSTRG.21378.2_2 - 0.059 13.6 0.8 55 4.4 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat PknG_TPR PF16918.3 MSTRG.21378.2_2 - 0.083 11.5 0.1 0.14 10.7 0.0 1.5 2 0 0 2 2 2 0 Protein kinase G tetratricopeptide repeat Fis1_TPR_C PF14853.4 MSTRG.21378.2_2 - 0.13 12.2 2.5 2.7 8.0 0.0 3.1 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.4 MSTRG.21378.2_2 - 0.14 12.2 1.7 34 4.5 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_20 PF14561.4 MSTRG.21378.2_2 - 0.21 11.8 1.7 9.7 6.5 0.0 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.21378.2_2 - 0.32 10.6 2.9 28 4.4 0.3 3.5 3 0 0 3 3 3 0 TPR repeat ANAPC3 PF12895.5 MSTRG.21378.2_2 - 0.34 11.0 4.8 2.9 8.0 0.6 2.8 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.4 MSTRG.21378.2_2 - 2.4 8.4 7.0 3 8.0 0.5 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat PRP38 PF03371.13 MSTRG.24972.2_2 - 0.00015 21.5 0.0 0.00028 20.7 0.0 1.4 1 0 0 1 1 1 1 PRP38 family PRP38 PF03371.13 MSTRG.24972.2_3 - 2.6e-44 151.0 0.0 3.8e-44 150.5 0.0 1.2 1 0 0 1 1 1 1 PRP38 family TROVE PF05731.9 MSTRG.15656.4_3 - 2.3e-72 244.1 10.4 2.3e-72 244.1 10.4 2.4 2 0 0 2 2 2 1 TROVE domain WD40 PF00400.30 MSTRG.15656.4_3 - 1.1e-32 111.4 61.8 5.3e-07 30.1 0.0 16.4 16 0 0 16 16 15 10 WD domain, G-beta repeat DUF4062 PF13271.4 MSTRG.15656.4_3 - 2.9e-16 59.5 0.0 1.7e-15 57.0 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4062) NACHT PF05729.10 MSTRG.15656.4_3 - 3.7e-11 43.1 0.4 1e-10 41.6 0.4 1.7 1 0 0 1 1 1 1 NACHT domain Nup160 PF11715.6 MSTRG.15656.4_3 - 5.1e-10 38.4 4.8 0.00077 18.1 0.0 5.6 4 2 1 5 5 5 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.5 MSTRG.15656.4_3 - 1.5e-07 31.5 4.0 0.071 13.3 0.1 7.5 5 3 3 8 8 8 1 Anaphase-promoting complex subunit 4 WD40 domain AAA_16 PF13191.4 MSTRG.15656.4_3 - 7.5e-06 26.3 0.3 0.00012 22.4 0.3 3.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.4 MSTRG.15656.4_3 - 2.1e-05 24.7 1.5 8.2e-05 22.8 0.0 2.9 3 0 0 3 3 3 1 AAA domain WD40_like PF17005.3 MSTRG.15656.4_3 - 0.00036 19.8 0.0 0.71 9.0 0.2 2.8 2 0 0 2 2 2 2 WD40-like domain DUF1676 PF07898.11 MSTRG.15656.4_3 - 0.0095 15.8 2.2 0.15 12.0 0.0 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1676) AAA_30 PF13604.4 MSTRG.15656.4_3 - 0.014 15.0 0.4 0.03 13.9 0.4 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.27 MSTRG.15656.4_3 - 0.052 13.8 0.0 0.72 10.1 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.11 MSTRG.15656.4_3 - 0.064 12.0 0.2 0.11 11.3 0.2 1.2 1 0 0 1 1 1 0 TIP49 C-terminus AAA_28 PF13521.4 MSTRG.15656.4_3 - 0.14 12.3 1.4 0.34 11.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain Ferlin_C PF16165.3 MSTRG.15656.4_3 - 2.6 7.8 5.4 1.9 8.3 2.6 2.2 2 0 0 2 2 2 0 Ferlin C-terminus HTH_5 PF01022.18 MSTRG.21123.1_1 - 0.19 11.5 0.8 0.32 10.7 0.8 1.3 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family Met_synt_B12 PF02965.15 MSTRG.21123.1_2 - 9.3e-114 379.3 0.0 1.3e-113 378.8 0.0 1.2 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain B12-binding PF02310.17 MSTRG.21123.1_2 - 9.8e-08 31.9 0.0 2.1e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 B12 binding domain DEAD PF00270.27 MSTRG.20732.1_3 - 4.9e-47 159.8 0.0 8.7e-47 159.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.20732.1_3 - 2.8e-23 82.3 0.1 4.8e-22 78.3 0.0 2.9 4 0 0 4 4 4 1 Helicase conserved C-terminal domain DUF4217 PF13959.4 MSTRG.20732.1_3 - 3.6e-17 62.2 0.6 7.3e-17 61.2 0.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.13 MSTRG.20732.1_3 - 1.8e-06 28.0 0.0 1.8e-06 28.0 0.0 2.1 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit RVT_1 PF00078.25 MSTRG.9856.1_2 - 1.1e-05 24.9 0.1 1.7e-05 24.3 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Spectrin PF00435.19 MSTRG.29700.1_3 - 4.8e-08 33.3 13.1 0.00032 21.0 3.7 3.2 2 1 0 2 2 2 2 Spectrin repeat THOC7 PF05615.11 MSTRG.29700.1_3 - 0.00074 19.7 3.1 0.00074 19.7 3.1 2.3 1 1 0 2 2 2 1 Tho complex subunit 7 Snapin_Pallidin PF14712.4 MSTRG.29700.1_3 - 0.0028 17.9 1.1 0.0028 17.9 1.1 3.1 2 1 1 3 3 3 1 Snapin/Pallidin KxDL PF10241.7 MSTRG.29700.1_3 - 0.015 15.4 1.7 0.015 15.4 1.7 3.0 2 2 1 3 3 3 0 Uncharacterized conserved protein ERM PF00769.17 MSTRG.29700.1_3 - 0.042 13.6 10.2 0.052 13.2 10.2 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Nsp1_C PF05064.11 MSTRG.29700.1_3 - 0.042 13.5 3.7 1.7 8.4 0.1 2.9 2 1 1 3 3 3 0 Nsp1-like C-terminal region DUF1664 PF07889.10 MSTRG.29700.1_3 - 0.11 12.4 4.9 0.71 9.7 0.4 3.1 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) YgaB PF14182.4 MSTRG.29700.1_3 - 0.18 12.2 5.2 2.3 8.6 0.1 3.4 3 1 0 3 3 3 0 YgaB-like protein CENP-F_leu_zip PF10473.7 MSTRG.29700.1_3 - 0.37 10.7 10.7 2.4 8.0 0.9 3.0 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4404 PF14357.4 MSTRG.29700.1_3 - 1.9 9.1 5.9 26 5.4 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) DUF745 PF05335.11 MSTRG.29700.1_3 - 2.5 7.7 10.0 3.9 7.1 7.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Mnd1 PF03962.13 MSTRG.29700.1_3 - 2.7 7.7 10.4 3.2 7.5 4.2 2.4 1 1 1 2 2 2 0 Mnd1 family Hrs_helical PF12210.6 MSTRG.29700.1_3 - 3.8 8.0 11.0 0.95 9.9 0.3 3.6 2 1 1 4 4 4 0 Hepatocyte growth factor-regulated tyrosine kinase substrate DUF755 PF05501.9 MSTRG.29700.1_3 - 4.4 7.5 7.9 1.3 9.2 4.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF755) IncA PF04156.12 MSTRG.29700.1_3 - 9.5 5.8 15.8 2.2 7.9 5.9 2.1 1 1 1 2 2 2 0 IncA protein Elongin_A PF06881.9 MSTRG.23088.1_3 - 0.0058 17.0 0.0 0.018 15.4 0.0 1.8 1 1 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A DUF1669 PF07894.10 MSTRG.29794.1_3 - 9.9e-10 38.3 0.0 1.4e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1669) fn3 PF00041.19 MSTRG.24447.4_1 - 4.7e-46 154.9 0.1 3.2e-14 52.9 0.0 4.6 4 0 0 4 4 4 3 Fibronectin type III domain I-set PF07679.14 MSTRG.24447.4_1 - 1.2e-28 98.9 0.0 4.7e-15 55.3 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.24447.4_1 - 2.6e-19 69.5 0.4 8.1e-11 42.3 0.2 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.24447.4_1 - 2.2e-14 53.4 0.7 1.9e-06 28.0 0.1 3.5 3 0 0 3 3 3 2 Immunoglobulin domain Pur_ac_phosph_N PF16656.3 MSTRG.24447.4_1 - 2.9e-09 37.2 0.0 0.0055 17.1 0.1 4.3 4 0 0 4 4 4 3 Purple acid Phosphatase, N-terminal domain ig PF00047.23 MSTRG.24447.4_1 - 3.3e-09 36.6 0.5 0.0013 18.7 0.1 2.9 2 0 0 2 2 2 2 Immunoglobulin domain Tissue_fac PF01108.15 MSTRG.24447.4_1 - 3e-07 30.1 0.1 0.0066 16.1 0.0 3.7 4 0 0 4 4 4 2 Tissue factor V-set PF07686.15 MSTRG.24447.4_1 - 2.3e-06 27.6 5.4 0.036 14.1 0.1 4.1 2 2 0 2 2 2 2 Immunoglobulin V-set domain Herpes_gE PF02480.14 MSTRG.24447.4_1 - 0.0013 17.4 0.0 0.75 8.3 0.0 2.2 1 1 1 2 2 2 2 Alphaherpesvirus glycoprotein E Adeno_E3_CR1 PF02440.13 MSTRG.24447.4_1 - 0.0019 17.8 0.4 0.13 12.0 0.1 2.4 2 0 0 2 2 2 1 Adenovirus E3 region protein CR1 C2-set_2 PF08205.10 MSTRG.24447.4_1 - 0.0067 16.3 0.3 2 8.4 0.0 2.5 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 MSTRG.24447.4_1 - 0.071 13.5 0.4 0.4 11.1 0.2 2.2 2 0 0 2 2 2 0 Immunoglobulin C1-set domain RRM_1 PF00076.20 MSTRG.13609.1_2 - 4.1e-11 42.4 0.1 6.4e-11 41.8 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.13609.1_2 - 0.089 12.8 0.0 0.31 11.1 0.0 1.9 1 1 0 1 1 1 0 RNA recognition motif PNP_UDP_1 PF01048.18 MSTRG.6318.1_3 - 2.2e-25 89.2 0.1 2.5e-25 89.0 0.1 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily bZIP_1 PF00170.19 MSTRG.17974.1_2 - 1.4e-07 31.3 15.6 2.5e-07 30.6 15.6 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 MSTRG.17974.1_2 - 5.4e-06 26.3 16.5 8.8e-06 25.6 16.5 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 MSTRG.17974.1_2 - 0.00015 22.1 8.9 0.00015 22.1 8.9 1.7 2 0 0 2 2 2 1 bZIP Maf transcription factor HALZ PF02183.16 MSTRG.17974.1_2 - 0.13 12.3 3.7 0.31 11.1 3.7 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper Prefoldin_2 PF01920.18 MSTRG.17974.1_2 - 0.15 11.9 4.2 0.25 11.2 4.2 1.3 1 0 0 1 1 1 0 Prefoldin subunit DivIC PF04977.13 MSTRG.17974.1_2 - 0.18 11.4 3.1 0.41 10.3 3.1 1.6 1 0 0 1 1 1 0 Septum formation initiator TPD52 PF04201.13 MSTRG.17974.1_2 - 0.23 10.9 2.2 0.39 10.2 2.2 1.2 1 0 0 1 1 1 0 Tumour protein D52 family IncA PF04156.12 MSTRG.17974.1_2 - 0.44 10.2 3.3 0.8 9.3 3.3 1.5 1 0 0 1 1 1 0 IncA protein APG6 PF04111.10 MSTRG.17974.1_2 - 1 8.5 6.7 1.4 8.1 6.7 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 M PF02370.14 MSTRG.17974.1_2 - 8.8 7.1 7.7 30 5.5 7.7 2.0 1 0 0 1 1 1 0 M protein repeat Ank_2 PF12796.5 MSTRG.5800.2_2 - 1.2e-30 105.7 4.3 1.6e-11 44.5 0.1 5.2 3 1 1 5 5 5 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.5800.2_2 - 6.6e-25 87.0 3.5 5.5e-09 36.3 0.6 6.0 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.4 MSTRG.5800.2_2 - 3.9e-24 84.2 3.3 1.4e-07 31.6 0.1 4.8 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.5800.2_2 - 8.5e-24 82.8 7.6 1.7e-05 24.9 0.4 6.0 4 1 1 5 5 5 4 Ankyrin repeat Ank_3 PF13606.4 MSTRG.5800.2_2 - 2.6e-18 64.1 2.3 0.012 16.0 0.1 6.9 7 0 0 7 7 7 4 Ankyrin repeat Laminin_II PF06009.10 MSTRG.5800.2_2 - 0.0075 16.1 3.1 0.0075 16.1 3.1 9.2 4 3 4 9 9 9 1 Laminin Domain II QPP PF07640.9 MSTRG.5800.2_2 - 0.1 12.3 0.3 0.35 10.6 0.3 1.9 1 0 0 1 1 1 0 QPP zf-H2C2_2 PF13465.4 MSTRG.6717.2_2 - 2.2e-34 116.3 59.6 7.2e-07 29.2 0.1 11.1 11 0 0 11 11 11 8 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.6717.2_2 - 4.5e-28 96.0 71.4 3.2e-05 24.0 1.5 9.9 10 0 0 10 10 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.6717.2_2 - 5.7e-26 88.8 64.4 2.6e-05 24.5 0.8 10.3 10 0 0 10 10 9 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.6717.2_2 - 1.4e-12 47.5 28.2 0.027 14.7 0.1 8.5 8 0 0 8 8 8 5 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 MSTRG.6717.2_2 - 2.5e-11 43.1 50.6 0.042 13.7 0.9 8.9 9 0 0 9 9 9 8 C2H2-type zinc finger zf-met PF12874.5 MSTRG.6717.2_2 - 2.8e-10 40.1 41.5 0.19 12.0 0.2 9.6 9 0 0 9 9 9 5 Zinc-finger of C2H2 type zf-C2HE PF16278.3 MSTRG.6717.2_2 - 2.4e-05 24.6 20.4 0.014 15.7 0.0 6.0 4 1 2 6 6 6 2 C2HE / C2H2 / C2HC zinc-binding finger Zn-ribbon_8 PF09723.8 MSTRG.6717.2_2 - 0.00034 20.5 32.7 1.4 9.0 0.8 7.0 3 2 3 6 6 6 3 Zinc ribbon domain zinc_ribbon_15 PF17032.3 MSTRG.6717.2_2 - 0.017 15.7 22.8 1.3 9.7 1.7 5.3 2 2 1 5 5 5 0 zinc-ribbon family zf-C2H2_11 PF16622.3 MSTRG.6717.2_2 - 0.048 13.3 39.9 0.41 10.3 0.0 8.8 9 0 0 9 9 9 0 zinc-finger C2H2-type zf-H2C2_5 PF13909.4 MSTRG.6717.2_2 - 0.13 11.9 30.6 0.059 13.0 0.7 6.5 7 0 0 7 7 7 0 C2H2-type zinc-finger domain DUF3268 PF11672.6 MSTRG.6717.2_2 - 0.27 11.5 14.3 0.63 10.3 0.7 4.5 4 1 1 5 5 5 0 zinc-finger-containing domain FYVE PF01363.19 MSTRG.6717.2_2 - 0.94 9.5 43.8 1.8 8.6 6.5 5.8 2 2 3 5 5 5 0 FYVE zinc finger HNH_5 PF14279.4 MSTRG.6717.2_2 - 0.97 9.2 24.5 2.8 7.7 2.1 7.0 5 1 1 6 6 6 0 HNH endonuclease Zf_RING PF16744.3 MSTRG.6717.2_2 - 5 7.2 24.1 1.4 9.0 0.1 5.9 3 1 3 6 6 6 0 KIAA1045 RING finger GAGA PF09237.9 MSTRG.6717.2_2 - 7 6.4 11.2 6.7 6.5 0.0 4.3 4 2 1 5 5 4 0 GAGA factor UL141 PF16758.3 MSTRG.28469.1_3 - 0.016 14.8 0.1 0.021 14.4 0.1 1.2 1 0 0 1 1 1 0 Herpes-like virus membrane glycoprotein UL141 DELLA PF12041.6 MSTRG.7657.1_3 - 0.23 11.2 1.7 0.48 10.2 1.5 1.7 1 1 0 1 1 1 0 Transcriptional regulator DELLA protein N terminal MGAT2 PF05060.12 MSTRG.22655.1_1 - 8.7e-154 511.6 0.6 1.1e-153 511.2 0.6 1.1 1 0 0 1 1 1 1 N-acetylglucosaminyltransferase II (MGAT2) LRR_8 PF13855.4 MSTRG.26599.1_3 - 3.5e-17 61.8 4.5 1e-09 37.8 0.0 4.1 3 1 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.5 MSTRG.26599.1_3 - 8.4e-09 35.4 10.4 0.00068 19.8 0.2 4.3 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 MSTRG.26599.1_3 - 0.0013 18.1 3.2 0.19 11.1 0.2 2.2 1 1 0 2 2 2 2 Leucine-rich repeat LRR_5 PF13306.4 MSTRG.26599.1_3 - 0.0049 16.7 0.2 0.078 12.8 0.0 2.2 1 1 1 2 2 2 1 Leucine rich repeats (6 copies) LRR_1 PF00560.31 MSTRG.26599.1_3 - 0.0056 16.8 3.0 67 4.4 0.0 5.1 5 1 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.4 MSTRG.26599.1_3 - 0.1 12.5 7.3 4.5 7.5 0.1 4.5 5 0 0 5 5 5 0 Leucine Rich repeat Guanylate_kin PF00625.19 MSTRG.11585.3_1 - 6e-60 201.9 0.1 1.2e-59 200.9 0.1 1.5 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.22 MSTRG.11585.3_1 - 1.2e-17 63.8 0.9 2.4e-17 62.9 0.9 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) L27 PF02828.14 MSTRG.11585.3_1 - 9.9e-17 60.3 1.8 8.3e-16 57.4 0.7 2.6 2 0 0 2 2 2 1 L27 domain SH3_2 PF07653.15 MSTRG.11585.3_1 - 4.4e-13 48.6 0.0 9.1e-13 47.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.11585.3_1 - 1.2e-08 34.2 0.3 2.9e-08 33.1 0.1 1.8 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 MSTRG.11585.3_1 - 7.1e-05 22.5 0.0 0.00018 21.1 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain PDZ_2 PF13180.4 MSTRG.11585.3_1 - 0.00073 19.7 0.0 0.0019 18.3 0.0 1.6 1 0 0 1 1 1 1 PDZ domain E1-E2_ATPase PF00122.18 MSTRG.16555.2_3 - 1.7e-65 220.3 2.7 2.1e-65 220.0 1.1 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 MSTRG.16555.2_3 - 1.7e-44 151.6 1.5 1.7e-44 151.6 1.5 1.9 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.24 MSTRG.16555.2_3 - 5.7e-20 72.4 0.0 2.9e-19 70.1 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.4 MSTRG.16555.2_3 - 2.1e-19 69.2 0.7 4.1e-19 68.3 0.7 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.24 MSTRG.16555.2_3 - 2.5e-18 65.4 0.5 1e-17 63.4 0.0 2.2 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 MSTRG.16555.2_3 - 6.7e-06 25.9 0.7 1.6e-05 24.6 0.7 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 MSTRG.16555.2_3 - 0.00051 20.4 0.0 0.0018 18.5 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase RRM_1 PF00076.20 MSTRG.10328.3_2 - 3e-32 110.1 0.3 4.9e-17 61.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.10328.3_2 - 1.1e-17 63.7 0.4 3.5e-08 33.3 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif CBFNT PF08143.9 MSTRG.10328.3_2 - 8.4e-09 36.6 15.7 8.4e-09 36.6 15.7 2.2 2 0 0 2 2 2 1 CBFNT (NUC161) domain RRM_3 PF08777.9 MSTRG.10328.3_2 - 0.00049 20.0 0.8 0.92 9.5 0.1 2.3 2 0 0 2 2 2 2 RNA binding motif Ribosomal_S7e PF01251.16 MSTRG.8283.1_3 - 2e-91 304.6 7.2 2.3e-91 304.4 7.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e ANF_receptor PF01094.26 MSTRG.17888.1_1 - 1.3e-52 178.9 0.0 1.8e-52 178.5 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 MSTRG.17888.1_1 - 2e-51 173.6 0.2 3.1e-51 173.0 0.2 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 MSTRG.17888.1_1 - 1.3e-44 150.9 0.0 2.3e-44 150.1 0.0 1.4 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 MSTRG.17888.1_1 - 8.9e-18 64.4 0.0 1.9e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.4 MSTRG.17888.1_1 - 0.0011 18.6 0.0 0.0016 18.1 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein SH3BGR PF04908.13 MSTRG.4319.2_1 - 2.9e-42 142.7 0.0 4.8e-42 142.0 0.0 1.4 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.22 MSTRG.4319.2_1 - 0.011 15.8 0.0 0.029 14.5 0.0 1.7 1 0 0 1 1 1 0 Glutaredoxin Phage_RpbA PF10789.7 MSTRG.25584.1_1 - 0.23 11.4 0.8 0.39 10.7 0.8 1.2 1 0 0 1 1 1 0 Phage RNA polymerase binding, RpbA Ammonium_transp PF00909.19 MSTRG.25584.1_3 - 1.2e-77 261.2 23.3 1.7e-77 260.6 23.3 1.2 1 0 0 1 1 1 1 Ammonium Transporter Family NAM-associated PF14303.4 MSTRG.25584.1_3 - 0.94 10.0 33.3 1.8 9.1 33.3 1.4 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Ribosomal_L28e PF01778.15 MSTRG.5017.1_2 - 8.9e-41 139.1 1.1 1.3e-40 138.6 1.1 1.2 1 0 0 1 1 1 1 Ribosomal L28e protein family HOOK PF05622.10 MSTRG.7306.1_1 - 2e-24 85.6 44.4 2e-24 85.6 44.4 2.6 1 1 1 3 3 3 3 HOOK protein Bul1_C PF04426.10 MSTRG.7306.1_1 - 0.31 10.3 6.6 1.2 8.4 6.6 2.1 1 1 0 1 1 1 0 Bul1 C terminus DUF3678 PF12435.6 MSTRG.18888.2_2 - 0.65 9.2 4.8 1.6 7.9 4.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3678) Ldl_recept_a PF00057.16 MSTRG.14110.3_3 - 1.2e-105 345.2 176.8 3.2e-12 46.3 12.2 11.4 11 0 0 11 11 11 10 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.15 MSTRG.14110.3_3 - 5.9e-46 154.6 3.8 3.4e-06 27.3 0.0 8.6 8 0 0 8 8 8 8 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 MSTRG.14110.3_3 - 1.7e-23 82.5 84.1 1.7e-09 37.7 8.5 10.7 11 1 1 12 12 12 6 Coagulation Factor Xa inhibitory site cEGF PF12662.5 MSTRG.14110.3_3 - 1.3e-13 50.5 39.2 0.0018 18.0 3.0 7.4 6 0 0 6 6 6 5 Complement Clr-like EGF-like EGF_CA PF07645.13 MSTRG.14110.3_3 - 2.8e-07 30.5 10.5 2.8e-07 30.5 10.5 14.4 11 4 3 14 14 14 1 Calcium-binding EGF domain DUF5050 PF16472.3 MSTRG.14110.3_3 - 3.7e-07 29.5 1.2 0.0041 16.3 0.0 3.3 3 1 1 4 4 4 2 Domain of unknown function (DUF5050) SGL PF08450.10 MSTRG.14110.3_3 - 3.8e-07 29.8 0.5 0.37 10.2 0.0 4.6 4 1 0 4 4 4 3 SMP-30/Gluconolaconase/LRE-like region PTase_Orf2 PF11468.6 MSTRG.14110.3_3 - 0.0054 16.0 0.0 1.1 8.4 0.0 2.2 2 0 0 2 2 2 2 Aromatic prenyltransferase Orf2 Arylesterase PF01731.18 MSTRG.14110.3_3 - 0.12 12.5 0.0 4.7 7.3 0.0 3.5 5 0 0 5 5 5 0 Arylesterase HNH_3 PF13392.4 MSTRG.12001.1_3 - 8e-07 28.7 0.4 1.5e-06 27.8 0.4 1.5 1 0 0 1 1 1 1 HNH endonuclease zf-MYND PF01753.16 MSTRG.12001.1_3 - 9.9e-07 28.6 14.0 2.6e-06 27.3 14.0 1.8 1 0 0 1 1 1 1 MYND finger SOUL PF04832.10 MSTRG.14603.1_2 - 4.2e-24 85.4 0.4 1.7e-23 83.5 0.2 1.9 2 0 0 2 2 2 1 SOUL heme-binding protein ATP-gua_PtransN PF02807.13 MSTRG.11139.1_1 - 3e-28 97.9 0.0 4.7e-28 97.3 0.0 1.3 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain ATP-gua_Ptrans PF00217.17 MSTRG.11139.1_1 - 3.7e-26 92.1 0.1 1.3e-21 77.2 0.0 2.2 2 0 0 2 2 2 2 ATP:guanido phosphotransferase, C-terminal catalytic domain JmjC PF02373.20 MSTRG.1720.1_1 - 1.1e-41 141.7 0.3 2.5e-41 140.6 0.1 1.8 2 0 0 2 2 2 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.4 MSTRG.1720.1_1 - 1.6e-30 105.4 15.3 1.6e-30 105.4 15.3 3.1 3 0 0 3 3 3 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.4 MSTRG.1720.1_1 - 7.4e-15 54.8 7.4 7.4e-15 54.8 7.4 4.4 1 1 2 4 4 4 1 PHD-like zinc-binding domain PHD_2 PF13831.4 MSTRG.1720.1_1 - 5e-13 48.2 6.5 5e-13 48.2 6.5 3.0 2 0 0 2 2 2 1 PHD-finger JmjN PF02375.15 MSTRG.1720.1_1 - 3.8e-10 39.4 0.0 9e-10 38.2 0.0 1.7 1 0 0 1 1 1 1 jmjN domain LBR_tudor PF09465.8 MSTRG.1720.1_1 - 6.5e-06 25.7 0.9 0.0062 16.2 0.1 2.5 2 0 0 2 2 2 2 Lamin-B receptor of TUDOR domain PHD PF00628.27 MSTRG.1720.1_1 - 3.2e-05 23.6 3.0 3.2e-05 23.6 3.0 3.9 3 1 1 4 4 4 2 PHD-finger DUF4537 PF15057.4 MSTRG.1720.1_1 - 0.0054 16.6 0.0 0.01 15.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) Neuropep_like PF15161.4 MSTRG.25926.1_2 - 6.1e-41 137.8 2.3 1.2e-40 136.9 2.3 1.5 1 0 0 1 1 1 1 Neuropeptide-like FH2 PF02181.21 MSTRG.7575.1_1 - 1.7e-77 260.9 11.3 3e-77 260.1 11.3 1.4 1 0 0 1 1 1 1 Formin Homology 2 Domain Drf_FH3 PF06367.14 MSTRG.7575.1_1 - 1.7e-29 102.7 1.1 1.7e-29 102.7 1.1 2.4 2 0 0 2 2 2 1 Diaphanous FH3 Domain Drf_GBD PF06371.11 MSTRG.7575.1_1 - 2.2e-16 59.9 1.7 1.4e-15 57.2 0.0 2.4 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain WH2 PF02205.18 MSTRG.7575.1_1 - 0.0031 17.2 0.0 0.0066 16.1 0.0 1.6 1 0 0 1 1 1 1 WH2 motif DUF3361 PF11841.6 MSTRG.7575.1_1 - 0.029 14.2 3.1 1.3 8.9 0.1 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF3361) ALMT PF11744.6 MSTRG.7575.1_1 - 0.034 12.8 2.2 0.059 12.1 2.2 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Exonuc_VII_L PF02601.13 MSTRG.7575.1_1 - 3.3 7.0 8.1 0.41 10.0 3.4 1.8 2 0 0 2 2 2 0 Exonuclease VII, large subunit adh_short PF00106.23 MSTRG.20935.1_1 - 5.9e-29 100.8 0.0 7.4e-29 100.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 MSTRG.20935.1_1 - 1.4e-14 54.1 0.0 1.8e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 MSTRG.20935.1_1 - 3.6e-07 30.1 0.0 5.5e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 KR domain Integrin_beta PF00362.16 MSTRG.4803.4_3 - 1.2e-98 329.7 0.0 1.8e-98 329.0 0.0 1.3 1 0 0 1 1 1 1 Integrin beta chain VWA domain fn3 PF00041.19 MSTRG.4803.4_3 - 5.7e-68 225.2 0.9 1.5e-18 66.8 0.0 4.5 4 0 0 4 4 4 4 Fibronectin type III domain Integrin_B_tail PF07965.10 MSTRG.4803.4_3 - 7.2e-16 58.3 12.6 7.2e-16 58.3 12.6 2.5 3 0 0 3 3 3 1 Integrin beta tail domain Calx-beta PF03160.12 MSTRG.4803.4_3 - 2.7e-15 56.2 0.1 7.3e-15 54.8 0.1 1.8 1 0 0 1 1 1 1 Calx-beta domain PSI_integrin PF17205.1 MSTRG.4803.4_3 - 3e-11 42.9 3.3 3e-11 42.9 3.3 4.7 5 0 0 5 5 5 1 Integrin plexin domain Pur_ac_phosph_N PF16656.3 MSTRG.4803.4_3 - 2e-08 34.5 0.0 0.8 10.2 0.0 5.5 5 1 0 5 5 5 2 Purple acid Phosphatase, N-terminal domain EGF_2 PF07974.11 MSTRG.4803.4_3 - 0.0001 22.4 85.9 0.0026 18.0 10.7 5.9 6 0 0 6 6 6 4 EGF-like domain SEA PF01390.18 MSTRG.4803.4_3 - 0.016 15.3 0.1 0.042 14.0 0.1 1.7 1 0 0 1 1 1 0 SEA domain Mucin2_WxxW PF13330.4 MSTRG.2838.1_3 - 3.7e-22 78.8 1.2 1.1e-21 77.2 0.6 2.1 2 0 0 2 2 2 1 Mucin-2 protein WxxW repeating region 1-cysPrx_C PF10417.7 MSTRG.2838.1_3 - 0.14 11.9 0.1 0.3 10.8 0.1 1.5 1 0 0 1 1 1 0 C-terminal domain of 1-Cys peroxiredoxin NKAIN PF05640.12 MSTRG.6596.1_3 - 5.2e-77 257.5 9.3 6.4e-77 257.3 9.3 1.1 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein SIR2_2 PF13289.4 MSTRG.4362.3_1 - 4e-21 75.5 0.0 6.6e-21 74.8 0.0 1.4 1 0 0 1 1 1 1 SIR2-like domain Sigma54_CBD PF04963.11 MSTRG.4362.3_1 - 0.13 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 factor, core binding domain EF-hand_3 PF09069.9 MSTRG.19972.2_1 - 6.1e-27 93.7 0.0 2.9e-26 91.6 0.0 2.1 2 0 0 2 2 2 1 EF-hand EF-hand_2 PF09068.9 MSTRG.19972.2_1 - 6.4e-25 87.5 0.2 1.2e-24 86.6 0.2 1.5 1 0 0 1 1 1 1 EF hand ZZ PF00569.15 MSTRG.19972.2_1 - 1.6e-09 37.3 6.4 4.6e-09 35.8 6.4 1.8 1 0 0 1 1 1 1 Zinc finger, ZZ type C1_2 PF03107.14 MSTRG.19972.2_1 - 0.00016 21.8 5.0 0.00043 20.4 5.0 1.7 1 0 0 1 1 1 1 C1 domain DUF4407 PF14362.4 MSTRG.19972.2_1 - 0.064 12.5 4.4 0.12 11.6 4.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Macoilin PF09726.7 MSTRG.19972.2_1 - 0.17 10.2 6.6 0.25 9.7 6.6 1.1 1 0 0 1 1 1 0 Transmembrane protein MerR-DNA-bind PF09278.9 MSTRG.19972.2_1 - 0.78 10.2 7.8 0.42 11.0 4.5 2.4 2 1 1 3 3 2 0 MerR, DNA binding DivIC PF04977.13 MSTRG.19972.2_1 - 0.92 9.2 6.3 1.6 8.5 0.1 2.7 2 0 0 2 2 2 0 Septum formation initiator ZapB PF06005.10 MSTRG.19972.2_1 - 0.95 9.8 13.6 5.5 7.4 0.8 2.6 2 0 0 2 2 2 0 Cell division protein ZapB Mnd1 PF03962.13 MSTRG.19972.2_1 - 2.2 8.0 5.6 2.4 7.8 3.8 1.8 1 1 0 2 2 2 0 Mnd1 family CRISPR_Cse2 PF09485.8 MSTRG.19972.2_1 - 2.3 8.6 7.2 2.2 8.7 5.0 2.2 2 1 0 2 2 1 0 CRISPR-associated protein Cse2 (CRISPR_cse2) TSNAXIP1_N PF15739.3 MSTRG.19972.2_1 - 7.7 6.8 7.2 22 5.3 1.0 2.7 3 0 0 3 3 3 0 Translin-associated factor X-interacting N-terminus YlqD PF11068.6 MSTRG.19972.2_1 - 7.8 6.7 7.3 15 5.8 7.3 1.4 1 0 0 1 1 1 0 YlqD protein SRP14 PF02290.13 MSTRG.7584.1_3 - 2e-23 82.4 0.0 3.6e-23 81.6 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle 14kD protein RNase_Zc3h12a PF11977.6 MSTRG.16479.2_2 - 3.9e-54 182.5 0.0 5.8e-54 182.0 0.0 1.2 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain zf-CCCH PF00642.22 MSTRG.16479.2_2 - 0.01 15.6 4.6 0.023 14.5 2.7 2.5 1 1 1 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.4 MSTRG.16479.2_2 - 0.04 14.3 6.3 0.21 12.0 6.3 2.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger NICE-1 PF15845.3 MSTRG.16479.2_2 - 2.6 8.8 17.5 0.64 10.7 4.6 2.8 2 0 0 2 2 2 0 Cysteine-rich C-terminal 1 family V-set PF07686.15 MSTRG.17166.2_3 - 0.00027 20.9 0.1 0.0073 16.3 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin V-set domain C2-set_2 PF08205.10 MSTRG.17166.2_3 - 0.018 14.9 0.0 0.045 13.7 0.0 1.7 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain DUF1689 PF07954.9 MSTRG.17166.2_3 - 0.11 12.8 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1689) BING4CT PF08149.9 MSTRG.20059.1_2 - 6.3e-34 115.5 0.0 5.2e-33 112.5 0.0 2.4 3 0 0 3 3 3 1 BING4CT (NUC141) domain WD40 PF00400.30 MSTRG.20059.1_2 - 0.00044 20.9 0.2 0.012 16.3 0.0 3.4 3 0 0 3 3 3 1 WD domain, G-beta repeat Coatomer_WDAD PF04053.12 MSTRG.20059.1_2 - 0.014 14.4 0.0 0.023 13.7 0.0 1.2 1 0 0 1 1 1 0 Coatomer WD associated region ANAPC4_WD40 PF12894.5 MSTRG.20059.1_2 - 0.046 13.9 0.0 25 5.1 0.0 3.7 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Bcl-2 PF00452.17 MSTRG.12743.1_1 - 2.6e-31 108.0 0.0 4.9e-31 107.1 0.0 1.5 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family Bcl-2_3 PF15286.4 MSTRG.12743.1_1 - 0.00015 22.3 0.0 0.00028 21.4 0.0 1.3 1 0 0 1 1 1 1 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like SelP_N PF04592.12 MSTRG.12743.1_2 - 3.3 6.9 8.4 5.6 6.2 8.4 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RRM_1 PF00076.20 MSTRG.11890.3_3 - 1.8e-61 203.7 0.0 3.6e-20 71.4 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 MSTRG.11890.3_3 - 2.7e-10 39.8 0.0 0.00025 20.5 0.0 3.2 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.11890.3_3 - 0.027 14.5 0.0 2 8.5 0.0 2.8 3 0 0 3 3 3 0 RNA recognition motif Diphthami_syn_2 PF01902.15 MSTRG.8767.1_1 - 2.3e-10 40.2 0.0 2.8e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 Diphthamide synthase tRNA_Me_trans PF03054.14 MSTRG.8767.1_1 - 0.019 13.7 0.0 0.022 13.4 0.0 1.0 1 0 0 1 1 1 0 tRNA methyl transferase QueC PF06508.11 MSTRG.8767.1_1 - 0.068 12.5 0.0 0.076 12.4 0.0 1.1 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC ThiI PF02568.12 MSTRG.8767.1_1 - 0.11 11.9 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) DUF1011 PF06237.10 MSTRG.9952.1_3 - 1.6e-40 137.3 9.5 1.6e-40 137.3 9.5 3.2 4 0 0 4 4 4 1 Protein of unknown function (DUF1011) MFS_1 PF07690.14 MSTRG.9952.1_3 - 0.00011 21.1 18.7 0.00011 21.1 18.7 2.8 2 2 0 2 2 2 1 Major Facilitator Superfamily Ribosomal_S7 PF00177.19 MSTRG.7909.1_1 - 1.2e-36 125.5 0.9 1.6e-36 125.1 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e CAF1 PF04857.18 MSTRG.27470.2_3 - 6.6e-87 291.5 1.9 1.1e-86 290.8 1.9 1.4 1 0 0 1 1 1 1 CAF1 family ribonuclease RNA_bind PF08675.9 MSTRG.27470.2_3 - 3.8e-32 110.0 0.1 7.8e-32 109.0 0.1 1.6 1 0 0 1 1 1 1 RNA binding domain R3H PF01424.20 MSTRG.27470.2_3 - 0.0014 18.4 0.0 0.0061 16.4 0.0 2.2 1 0 0 1 1 1 1 R3H domain RRM_1 PF00076.20 MSTRG.27470.2_3 - 0.14 11.9 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NCBP3 PF10309.7 MSTRG.27470.2_3 - 0.15 11.8 0.2 0.33 10.7 0.2 1.5 1 0 0 1 1 1 0 Nuclear cap-binding protein subunit 3 Glyco_transf_90 PF05686.10 MSTRG.26814.1_2 - 7.2e-108 360.9 0.9 8.8e-108 360.6 0.9 1.0 1 0 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.4 MSTRG.26814.1_2 - 0.023 15.0 0.0 0.041 14.2 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferases group 1 Hormone_recep PF00104.28 MSTRG.4453.2_3 - 1.2e-40 139.1 0.0 2.1e-40 138.4 0.0 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 MSTRG.4453.2_3 - 4.4e-30 103.8 18.3 8e-30 103.0 18.3 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Nebulin PF00880.16 MSTRG.1479.7_1 - 0 1680.9 568.0 2.5e-10 40.0 2.0 138.0 143 0 0 143 143 143 111 Nebulin repeat Peptidase_M24 PF00557.22 MSTRG.1479.7_1 - 4.3e-14 52.6 3.9 0.27 10.7 0.0 9.2 9 0 0 9 9 9 5 Metallopeptidase family M24 SH3_1 PF00018.26 MSTRG.1479.7_1 - 3.1e-12 45.8 0.0 1.4e-11 43.6 0.0 2.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.1479.7_1 - 3.4e-12 45.9 0.0 7.3e-12 44.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.1479.7_1 - 8.7e-06 25.2 0.0 7.8e-05 22.2 0.0 2.7 2 0 0 2 2 2 1 Variant SH3 domain Toprim_2 PF13155.4 MSTRG.1479.7_1 - 0.12 12.7 4.9 67 3.9 0.0 5.6 5 0 0 5 5 5 0 Toprim-like VGLL4 PF15245.4 MSTRG.21049.3_3 - 4.4e-94 314.4 7.5 1.3e-93 312.9 7.5 1.8 1 1 0 1 1 1 1 Transcription cofactor vestigial-like protein 4 Vg_Tdu PF07545.12 MSTRG.21049.3_3 - 0.0054 16.3 0.0 2.7 7.7 0.0 2.5 2 0 0 2 2 2 2 Vestigial/Tondu family TORC_M PF12885.5 MSTRG.10624.1_3 - 7.7e-56 188.3 7.9 7.7e-56 188.3 7.9 2.8 2 1 0 2 2 2 1 Transducer of regulated CREB activity middle domain TORC_C PF12886.5 MSTRG.10624.1_3 - 1.5e-32 111.9 1.8 1.5e-32 111.9 1.8 2.0 2 0 0 2 2 2 1 Transducer of regulated CREB activity, C terminus zf-H2C2_2 PF13465.4 MSTRG.27005.3_3 - 4.1e-11 42.7 26.4 9.5e-07 28.9 0.4 4.6 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.27005.3_3 - 1.7e-08 34.4 35.5 6e-05 23.2 0.7 4.8 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.27005.3_3 - 0.00088 19.8 8.6 0.0033 18.0 1.8 5.6 6 0 0 6 6 6 3 C2H2-type zinc finger EF1_GNE PF00736.17 MSTRG.15599.4_3 - 1.3e-35 121.3 1.4 3.3e-35 120.0 0.6 2.0 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.7 MSTRG.15599.4_3 - 5.4e-12 45.8 6.2 5.4e-12 45.8 6.2 2.7 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region JIP_LZII PF16471.3 MSTRG.15599.4_3 - 0.012 15.6 0.9 0.037 14.1 0.9 1.8 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II DivIC PF04977.13 MSTRG.15599.4_3 - 0.05 13.2 0.2 0.05 13.2 0.2 1.9 2 0 0 2 2 2 0 Septum formation initiator CCD48 PF15799.3 MSTRG.15599.4_3 - 0.13 10.6 12.2 0.0049 15.2 6.1 1.7 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 48 ATG16 PF08614.9 MSTRG.15599.4_3 - 2.3 8.2 12.2 0.56 10.2 7.0 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Stm1_N PF09598.8 MSTRG.15599.4_3 - 9.1 7.1 9.6 16 6.3 0.2 3.6 3 0 0 3 3 3 0 Stm1 RUN PF02759.17 MSTRG.18449.1_1 - 6.7e-15 55.1 0.0 8.6e-15 54.7 0.0 1.1 1 0 0 1 1 1 1 RUN domain PDZ PF00595.22 MSTRG.22784.1_3 - 6.1e-22 77.6 0.0 2.3e-11 43.7 0.0 2.1 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.22784.1_3 - 7.6e-14 51.7 0.0 1.4e-05 25.2 0.0 2.2 2 0 0 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.4 MSTRG.22784.1_3 - 0.031 14.2 0.1 0.21 11.5 0.0 2.2 2 0 0 2 2 2 0 Tricorn protease PDZ domain GRASP55_65 PF04495.12 MSTRG.22784.1_3 - 0.07 13.3 0.0 1.1 9.4 0.0 2.1 2 0 0 2 2 2 0 GRASP55/65 PDZ-like domain MT-A70 PF05063.12 MSTRG.9054.1_1 - 3.3e-38 131.2 0.0 5e-38 130.6 0.0 1.3 1 0 0 1 1 1 1 MT-A70 I-set PF07679.14 MSTRG.242.1_1 - 3e-30 104.0 3.0 2.5e-14 52.9 0.3 3.0 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.23 MSTRG.242.1_1 - 8.2e-19 67.4 0.6 1.3e-06 28.4 0.2 3.1 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.242.1_1 - 3.1e-18 66.0 0.0 5.2e-09 36.5 0.0 3.1 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.242.1_1 - 4.4e-13 49.3 0.1 2e-08 34.3 0.0 3.1 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 MSTRG.242.1_1 - 1.6e-06 28.1 2.7 0.15 12.1 1.2 4.1 3 1 0 3 3 3 1 Immunoglobulin V-set domain Izumo-Ig PF16706.3 MSTRG.242.1_1 - 0.0048 16.8 3.3 0.56 10.1 0.5 3.7 3 2 0 3 3 3 1 Izumo-like Immunoglobulin domain C1-set PF07654.13 MSTRG.242.1_1 - 0.0081 16.5 0.4 0.49 10.8 0.4 3.3 3 1 0 3 3 3 1 Immunoglobulin C1-set domain Ig_4 PF16680.3 MSTRG.242.1_1 - 0.011 15.9 4.4 0.017 15.3 1.5 2.6 2 1 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain Ribosomal_L27 PF01016.17 MSTRG.242.1_1 - 0.026 14.4 0.0 0.049 13.5 0.0 1.4 1 0 0 1 1 1 0 Ribosomal L27 protein YscW PF09619.8 MSTRG.242.1_1 - 0.12 12.6 0.1 0.18 12.0 0.1 1.3 1 0 0 1 1 1 0 Type III secretion system lipoprotein chaperone (YscW) C2-set PF05790.13 MSTRG.242.1_1 - 0.81 9.8 4.3 12 6.0 0.1 3.4 3 1 1 4 4 4 0 Immunoglobulin C2-set domain DUF2554 PF10829.6 MSTRG.29428.1_3 - 0.14 12.5 0.1 0.24 11.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2554) TRAM_LAG1_CLN8 PF03798.14 MSTRG.7171.1_2 - 2.4e-36 125.2 15.8 4.2e-36 124.4 15.8 1.4 1 0 0 1 1 1 1 TLC domain Pkinase PF00069.23 MSTRG.161.4_3 - 8.6e-40 136.6 0.1 1e-39 136.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.161.4_3 - 1.2e-29 103.3 0.0 1.5e-29 103.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.161.4_3 - 0.00066 18.9 0.0 0.043 13.0 0.0 2.0 2 0 0 2 2 2 2 Kinase-like RIO1 PF01163.20 MSTRG.161.4_3 - 0.053 13.0 0.1 0.079 12.4 0.1 1.2 1 0 0 1 1 1 0 RIO1 family PCI PF01399.25 MSTRG.23287.1_2 - 5.9e-07 29.8 0.1 1.2e-06 28.9 0.1 1.5 1 0 0 1 1 1 1 PCI domain NAM-associated PF14303.4 MSTRG.23287.1_2 - 2.4 8.7 6.3 3.7 8.0 6.3 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Anoctamin PF04547.10 MSTRG.11707.1_1 - 6.9e-154 512.7 19.3 8.9e-154 512.3 19.3 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.3 MSTRG.11707.1_1 - 2.5e-69 233.3 0.6 3.7e-69 232.8 0.6 1.2 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin zf-DHHC PF01529.18 MSTRG.11707.1_1 - 0.2 11.6 7.1 2.4 8.1 1.1 3.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase Beach PF02138.16 MSTRG.5623.1_1 - 3e-111 371.1 0.0 4.2e-111 370.6 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.30 MSTRG.5623.1_1 - 8.1e-15 54.8 23.9 0.0015 19.2 0.0 7.6 6 1 1 7 7 7 4 WD domain, G-beta repeat GRAM PF02893.18 MSTRG.5623.1_1 - 2.5e-13 49.7 0.6 1.1e-12 47.7 0.1 2.3 2 0 0 2 2 2 1 GRAM domain ANAPC4_WD40 PF12894.5 MSTRG.5623.1_1 - 4e-08 33.3 1.0 0.00011 22.3 0.0 3.9 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PH_BEACH PF14844.4 MSTRG.5623.1_1 - 9.5e-06 25.5 0.0 0.0067 16.4 0.0 3.4 2 1 0 2 2 2 1 PH domain associated with Beige/BEACH WD40_like PF17005.3 MSTRG.5623.1_1 - 1.6e-05 24.3 0.0 5e-05 22.6 0.0 1.7 2 0 0 2 2 2 1 WD40-like domain Cytochrom_D1 PF02239.14 MSTRG.5623.1_1 - 0.00083 17.9 0.4 0.0018 16.8 0.1 1.7 2 0 0 2 2 2 1 Cytochrome D1 heme domain eIF2A PF08662.9 MSTRG.5623.1_1 - 0.0059 16.4 0.0 0.018 14.8 0.0 1.8 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Ldl_recept_a PF00057.16 MSTRG.14110.1_2 - 8.6e-274 883.3 568.7 6.1e-13 48.6 6.7 33.7 33 0 0 33 33 33 29 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.15 MSTRG.14110.1_2 - 3.3e-165 536.3 77.0 6.4e-14 52.0 0.0 29.2 30 1 0 30 30 30 23 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 MSTRG.14110.1_2 - 3.6e-35 119.8 137.1 5.7e-10 39.2 10.1 25.6 21 2 6 27 27 27 12 Coagulation Factor Xa inhibitory site DUF5050 PF16472.3 MSTRG.14110.1_2 - 2.1e-25 89.4 0.5 2.1e-11 43.5 0.0 7.0 7 1 1 8 8 8 4 Domain of unknown function (DUF5050) SGL PF08450.10 MSTRG.14110.1_2 - 9.5e-20 71.1 29.6 0.008 15.7 0.0 12.4 8 5 2 11 11 11 6 SMP-30/Gluconolaconase/LRE-like region cEGF PF12662.5 MSTRG.14110.1_2 - 8.1e-10 38.3 1.1 8.1e-10 38.3 1.1 16.0 16 0 0 16 16 16 8 Complement Clr-like EGF-like hEGF PF12661.5 MSTRG.14110.1_2 - 0.00038 20.9 7.1 0.00038 20.9 7.1 28.9 34 1 0 34 34 34 7 Human growth factor-like EGF EGF PF00008.25 MSTRG.14110.1_2 - 0.0011 19.0 12.2 0.0011 19.0 12.2 35.4 38 0 0 38 38 38 9 EGF-like domain TadE PF07811.10 MSTRG.14110.1_2 - 0.12 12.6 2.9 0.19 11.9 2.1 1.7 2 0 0 2 2 2 0 TadE-like protein ANTH PF07651.14 MSTRG.17089.1_1 - 2.2e-73 246.5 0.1 2.2e-73 246.5 0.1 2.2 2 0 0 2 2 2 1 ANTH domain I_LWEQ PF01608.15 MSTRG.17089.1_1 - 1.2e-53 181.3 8.7 1.2e-53 181.3 8.7 5.2 4 2 1 5 5 5 1 I/LWEQ domain HIP1_clath_bdg PF16515.3 MSTRG.17089.1_1 - 1.9e-25 89.2 17.2 1.9e-25 89.2 17.2 6.7 5 2 2 7 7 7 3 Clathrin-binding domain of Huntingtin-interacting protein 1 Nsp1_C PF05064.11 MSTRG.17089.1_1 - 0.36 10.5 11.6 0.11 12.2 5.6 3.0 1 1 1 2 2 2 0 Nsp1-like C-terminal region Sec34 PF04136.13 MSTRG.17089.1_1 - 10 5.9 14.6 13 5.6 2.4 3.2 2 0 0 2 2 2 0 Sec34-like family FAD_binding_3 PF01494.17 MSTRG.17373.3_1 - 4.6e-07 29.3 0.0 1.4e-06 27.7 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.4 MSTRG.17373.3_1 - 3.7e-06 26.3 0.1 1.3e-05 24.5 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.12 MSTRG.17373.3_1 - 1.1e-05 24.7 0.0 2.3e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 MSTRG.17373.3_1 - 7.2e-05 21.9 0.0 0.00012 21.2 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.12 MSTRG.17373.3_1 - 0.00015 20.5 0.0 0.0003 19.5 0.0 1.5 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_7 PF13241.4 MSTRG.17373.3_1 - 0.00018 21.8 0.0 0.00036 20.8 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding DAO PF01266.22 MSTRG.17373.3_1 - 0.00023 20.8 0.0 0.00034 20.2 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.4 MSTRG.17373.3_1 - 0.0004 20.4 0.0 0.00085 19.4 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.25 MSTRG.17373.3_1 - 0.00082 19.8 0.1 0.0029 18.0 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.15 MSTRG.17373.3_1 - 0.0043 16.2 0.0 0.008 15.3 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.10 MSTRG.17373.3_1 - 0.0046 15.9 0.0 0.0086 15.0 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_oxidored PF12831.5 MSTRG.17373.3_1 - 0.007 15.6 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.20 MSTRG.17373.3_1 - 0.023 13.7 0.0 0.036 13.0 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.19 MSTRG.17373.3_1 - 0.056 12.6 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain zf-CXXC PF02008.18 MSTRG.23436.1_1 - 2.7 8.0 7.3 1.1 9.2 0.7 2.5 2 0 0 2 2 2 0 CXXC zinc finger domain DUF1899 PF08953.9 MSTRG.3064.1_2 - 3.5e-32 110.0 0.1 6.3e-32 109.1 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.3 MSTRG.3064.1_2 - 8.7e-20 70.2 0.1 1.9e-19 69.1 0.1 1.6 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.30 MSTRG.3064.1_2 - 3.3e-12 46.6 9.3 0.0004 21.0 0.8 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.3064.1_2 - 2.3e-06 27.7 0.4 0.0069 16.5 0.0 2.8 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Lebercilin PF15619.4 MSTRG.3064.1_2 - 0.19 11.2 1.2 0.27 10.7 1.2 1.1 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease HMMR_N PF15905.3 MSTRG.3064.1_2 - 0.22 10.8 1.6 0.32 10.3 1.6 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Isy1 PF06246.10 MSTRG.29179.1_3 - 7.2e-08 32.2 3.3 8.3e-08 32.0 3.3 1.0 1 0 0 1 1 1 1 Isy1-like splicing family SNARE PF05739.17 MSTRG.20822.1_2 - 0.00018 21.3 0.1 0.00031 20.5 0.1 1.4 1 0 0 1 1 1 1 SNARE domain zf-U1 PF06220.10 MSTRG.2647.1_1 - 1.2e-22 79.2 7.5 2.4e-22 78.3 7.5 1.5 1 0 0 1 1 1 1 U1 zinc finger PMP22_Claudin PF00822.18 MSTRG.14949.1_3 - 8.5e-44 149.2 9.9 1.1e-43 148.8 9.9 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family DUF4064 PF13273.4 MSTRG.14949.1_3 - 0.027 14.7 2.1 8.6 6.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) Laminin_N PF00055.15 MSTRG.26017.1_2 - 8.8e-87 290.4 1.0 8.8e-87 290.4 1.0 3.3 3 1 1 4 4 4 1 Laminin N-terminal (Domain VI) NTR PF01759.19 MSTRG.26017.1_2 - 2.1e-31 107.8 0.2 4.3e-31 106.7 0.2 1.6 1 0 0 1 1 1 1 UNC-6/NTR/C345C module Laminin_EGF PF00053.22 MSTRG.26017.1_2 - 4.4e-25 87.4 65.0 3.3e-10 39.8 14.0 5.1 5 0 0 5 5 5 3 Laminin EGF domain BNR_6 PF15899.3 MSTRG.26017.1_2 - 0.075 13.0 0.3 0.42 10.7 0.0 2.5 2 0 0 2 2 2 0 BNR-Asp box repeat HEAT PF02985.20 MSTRG.3047.1_1 - 0.0026 17.7 4.9 0.5 10.6 0.0 4.7 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.4 MSTRG.3047.1_1 - 0.042 14.1 1.7 15 5.9 0.0 3.7 4 1 0 4 4 4 0 HEAT repeats SCHIP-1 PF10148.7 MSTRG.8119.1_3 - 2.6e-16 59.8 12.4 1.6e-08 34.3 1.8 2.6 3 0 0 3 3 3 2 Schwannomin-interacting protein 1 Bindin PF02084.13 MSTRG.8119.1_3 - 0.11 12.7 0.5 0.19 11.8 0.5 1.3 1 0 0 1 1 1 0 Bindin Luteo_P1-P2 PF08467.8 MSTRG.8119.1_3 - 1.5 7.9 5.3 3.2 6.8 0.2 2.3 1 1 0 2 2 2 0 Luteovirus RNA polymerase P1-P2/replicase PSI PF01437.23 MSTRG.406.3_1 - 3.5e-06 27.3 11.1 3.5e-06 27.3 11.1 2.5 2 0 0 2 2 2 1 Plexin repeat Syndecan PF01034.18 MSTRG.406.3_1 - 0.49 10.2 2.4 1.1 9.1 2.4 1.5 1 0 0 1 1 1 0 Syndecan domain NUDIX PF00293.26 MSTRG.20594.3_3 - 1.3e-12 47.7 0.3 4.3e-12 46.1 0.0 2.0 3 0 0 3 3 3 1 NUDIX domain Zona_pellucida PF00100.21 MSTRG.18624.3_3 - 3.7e-36 125.1 0.1 4.8e-36 124.7 0.1 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain MIF4G_like_2 PF09090.9 MSTRG.15883.5_3 - 1.4e-86 290.1 7.4 2.2e-86 289.4 7.4 1.3 1 0 0 1 1 1 1 MIF4G like MIF4G_like PF09088.9 MSTRG.15883.5_3 - 7e-36 123.6 0.1 3.7e-35 121.2 0.2 2.1 2 0 0 2 2 2 1 MIF4G like Mnd1 PF03962.13 MSTRG.15883.5_3 - 0.0071 16.1 5.2 0.012 15.3 5.2 1.3 1 0 0 1 1 1 1 Mnd1 family PHM7_cyt PF14703.4 MSTRG.15883.5_3 - 0.0086 16.2 3.2 0.016 15.4 3.2 1.4 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Vfa1 PF08432.8 MSTRG.15883.5_3 - 0.01 16.1 5.3 0.017 15.3 5.3 1.3 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 Jnk-SapK_ap_N PF09744.7 MSTRG.15883.5_3 - 0.013 15.6 7.4 0.022 14.8 7.4 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF342 PF03961.11 MSTRG.15883.5_3 - 0.018 13.6 2.5 0.024 13.1 2.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF1664 PF07889.10 MSTRG.15883.5_3 - 0.035 14.0 2.9 0.081 12.8 2.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF106 PF01956.14 MSTRG.15883.5_3 - 0.037 13.6 2.1 0.067 12.8 2.1 1.4 1 0 0 1 1 1 0 Integral membrane protein DUF106 tRNA_bind_2 PF13725.4 MSTRG.15883.5_3 - 0.037 13.6 6.5 0.074 12.6 6.5 1.4 1 0 0 1 1 1 0 Possible tRNA binding domain IncA PF04156.12 MSTRG.15883.5_3 - 0.053 13.2 4.0 0.082 12.6 4.0 1.3 1 0 0 1 1 1 0 IncA protein AAA_11 PF13086.4 MSTRG.15883.5_3 - 0.055 13.1 2.7 0.082 12.5 2.7 1.2 1 0 0 1 1 1 0 AAA domain Ald_deCOase PF11266.6 MSTRG.15883.5_3 - 0.057 13.0 1.4 0.13 11.8 0.6 1.8 2 0 0 2 2 2 0 Long-chain fatty aldehyde decarbonylase DUF1510 PF07423.9 MSTRG.15883.5_3 - 0.058 12.7 6.3 0.09 12.1 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) OmpH PF03938.12 MSTRG.15883.5_3 - 0.06 13.2 9.9 0.11 12.4 9.9 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) HemX PF04375.12 MSTRG.15883.5_3 - 0.067 12.3 5.0 0.087 12.0 4.4 1.4 2 0 0 2 2 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase GBP_C PF02841.12 MSTRG.15883.5_3 - 0.068 12.4 8.3 0.11 11.7 8.3 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain DUF4407 PF14362.4 MSTRG.15883.5_3 - 0.077 12.2 0.7 0.13 11.5 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Swi5 PF07061.9 MSTRG.15883.5_3 - 0.079 12.9 8.1 0.77 9.7 1.8 2.4 2 0 0 2 2 2 0 Swi5 CLZ PF16526.3 MSTRG.15883.5_3 - 0.092 13.0 8.5 3.2 8.0 1.7 3.3 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Folliculin PF11704.6 MSTRG.15883.5_3 - 0.093 12.4 4.8 0.15 11.8 4.8 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF2203 PF09969.7 MSTRG.15883.5_3 - 0.11 13.1 3.4 0.21 12.2 3.4 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Cob_adeno_trans PF01923.16 MSTRG.15883.5_3 - 0.14 12.2 1.4 0.32 11.0 1.4 1.6 1 0 0 1 1 1 0 Cobalamin adenosyltransferase Alanine_zipper PF11839.6 MSTRG.15883.5_3 - 0.22 11.7 3.2 2.3 8.4 0.6 2.3 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein Bap31 PF05529.10 MSTRG.15883.5_3 - 0.28 10.7 4.6 0.56 9.6 4.6 1.6 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like PRKG1_interact PF15898.3 MSTRG.15883.5_3 - 0.31 11.9 8.6 0.56 11.0 8.6 1.4 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain CorA PF01544.16 MSTRG.15883.5_3 - 0.45 9.7 5.5 0.8 8.8 0.3 2.4 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein SOGA PF11365.6 MSTRG.15883.5_3 - 0.45 11.5 10.4 0.88 10.6 10.4 1.5 1 0 0 1 1 1 0 Protein SOGA Atg14 PF10186.7 MSTRG.15883.5_3 - 0.59 9.0 7.0 2 7.3 5.6 2.0 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Prefoldin_2 PF01920.18 MSTRG.15883.5_3 - 0.62 9.9 14.4 3.1 7.7 2.2 2.4 2 0 0 2 2 2 0 Prefoldin subunit Fib_alpha PF08702.8 MSTRG.15883.5_3 - 1.7 8.7 10.0 1.2 9.2 6.7 2.3 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family RmuC PF02646.14 MSTRG.15883.5_3 - 1.8 7.5 10.8 1.1 8.2 0.8 2.3 1 1 1 2 2 2 0 RmuC family DASH_Spc34 PF08657.8 MSTRG.15883.5_3 - 2.4 7.8 11.2 4.5 6.9 11.2 1.4 1 0 0 1 1 1 0 DASH complex subunit Spc34 LPP PF04728.11 MSTRG.15883.5_3 - 3.1 8.1 5.5 21 5.4 0.6 2.3 2 0 0 2 2 2 0 Lipoprotein leucine-zipper DivIC PF04977.13 MSTRG.15883.5_3 - 3.5 7.3 8.6 5 6.8 1.6 2.4 2 0 0 2 2 2 0 Septum formation initiator SlyX PF04102.10 MSTRG.15883.5_3 - 4.1 7.9 9.8 7.5 7.1 2.3 2.9 1 1 1 2 2 2 0 SlyX CCDC-167 PF15188.4 MSTRG.15883.5_3 - 6.9 7.0 11.1 6.8 7.0 9.0 2.0 2 0 0 2 2 1 0 Coiled-coil domain-containing protein 167 SH3_1 PF00018.26 MSTRG.4201.1_2 - 1.5e-05 24.4 0.2 9e-05 21.9 0.2 2.1 1 1 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.4201.1_2 - 0.00013 21.5 0.0 0.0003 20.3 0.0 1.7 2 1 0 2 2 2 1 Variant SH3 domain PDZ PF00595.22 MSTRG.4201.1_2 - 0.013 15.7 0.1 0.02 15.1 0.1 1.3 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) eIF-5a PF01287.18 MSTRG.1047.1_2 - 4.9e-26 90.5 0.5 7e-26 90.0 0.5 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold SGS PF05002.13 MSTRG.12052.1_1 - 1.6e-32 111.3 1.5 3.9e-32 110.1 1.5 1.7 1 0 0 1 1 1 1 SGS domain CS PF04969.14 MSTRG.12052.1_1 - 5.9e-15 55.9 0.2 1.4e-14 54.7 0.1 1.8 2 0 0 2 2 2 1 CS domain TPR_2 PF07719.15 MSTRG.12052.1_1 - 6.3e-07 28.9 2.7 0.074 13.1 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.12052.1_1 - 6.3e-05 22.5 3.1 0.097 12.4 0.3 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.12052.1_1 - 0.0013 19.1 2.9 0.0034 17.7 2.1 2.0 1 1 1 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.12052.1_1 - 0.13 12.3 1.6 0.24 11.5 1.6 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.4 MSTRG.12052.1_1 - 0.16 12.1 0.5 1.3 9.1 0.1 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat GCR PF02155.13 MSTRG.7359.1_3 - 1.1e-53 182.5 12.3 1.6e-53 182.0 12.3 1.1 1 0 0 1 1 1 1 Glucocorticoid receptor Hormone_recep PF00104.28 MSTRG.7359.1_3 - 8.4e-30 103.8 4.5 1.4e-29 103.0 4.5 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 MSTRG.7359.1_3 - 2.5e-27 95.0 13.2 2.5e-27 95.0 13.2 1.8 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) RRM_1 PF00076.20 MSTRG.20813.1_2 - 2.1e-13 49.7 0.0 0.0031 17.1 0.0 4.2 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 MSTRG.20813.1_2 - 0.012 15.5 0.1 0.11 12.4 0.0 2.4 3 0 0 3 3 3 0 RNA binding motif SprT-like PF10263.7 MSTRG.15067.1_2 - 5.3e-41 139.9 0.0 8.2e-41 139.3 0.0 1.3 1 0 0 1 1 1 1 SprT-like family PRP21_like_P PF12230.6 MSTRG.15067.1_2 - 0.1 12.3 0.2 0.16 11.7 0.2 1.3 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein Ras PF00071.20 MSTRG.12632.1_3 - 3e-60 202.3 0.2 4.1e-60 201.9 0.2 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.12632.1_3 - 2.4e-34 118.0 0.0 5e-34 117.0 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.12632.1_3 - 6.2e-11 41.9 0.0 8.5e-11 41.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 MSTRG.12632.1_3 - 0.0007 18.9 0.1 0.001 18.3 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 MSTRG.12632.1_3 - 0.0013 18.6 0.0 0.0021 18.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 MSTRG.12632.1_3 - 0.022 14.5 0.7 1.6 8.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_16 PF13191.4 MSTRG.12632.1_3 - 0.16 12.2 0.0 0.26 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Homeobox PF00046.27 MSTRG.26426.1_3 - 9.8e-24 82.8 2.3 1.5e-23 82.2 2.3 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 MSTRG.26426.1_3 - 0.0079 15.9 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 Homeobox KN domain LRR_8 PF13855.4 MSTRG.22996.1_3 - 2.6e-39 132.6 40.2 4.7e-09 35.8 0.7 9.1 5 3 4 9 9 9 9 Leucine rich repeat LRR_4 PF12799.5 MSTRG.22996.1_3 - 2.5e-20 72.0 34.2 1.1e-06 28.7 1.4 8.4 5 1 4 9 9 9 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 MSTRG.22996.1_3 - 2.4e-09 36.2 28.1 0.41 11.2 0.1 10.6 10 2 0 10 10 10 4 Leucine Rich Repeat LRR_5 PF13306.4 MSTRG.22996.1_3 - 4e-07 29.9 4.3 0.048 13.5 0.7 4.5 1 1 2 4 4 4 3 Leucine rich repeats (6 copies) FNIP PF05725.10 MSTRG.22996.1_3 - 3.9e-06 26.8 1.1 0.00022 21.2 0.0 4.5 2 2 1 3 3 3 1 FNIP Repeat LRRNT PF01462.16 MSTRG.22996.1_3 - 0.0053 16.2 0.8 0.1 12.2 0.1 3.0 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain Pox_A9 PF04835.10 MSTRG.22996.1_3 - 0.27 11.3 2.7 0.72 9.9 1.3 2.3 2 0 0 2 2 2 0 A9 protein conserved region LRR_6 PF13516.4 MSTRG.22996.1_3 - 7.2 6.8 38.4 7.6 6.7 0.7 9.4 10 0 0 10 10 10 0 Leucine Rich repeat LRR_9 PF14580.4 MSTRG.22996.1_3 - 9.2 5.6 13.8 13 5.1 0.4 4.9 2 2 2 5 5 5 0 Leucine-rich repeat Steroid_dh PF02544.14 MSTRG.25768.1_3 - 1.5e-55 187.2 2.0 1.5e-55 187.2 2.0 2.0 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.10 MSTRG.25768.1_3 - 4e-05 23.1 0.4 4e-05 23.1 0.4 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) zf-C2H2 PF00096.24 MSTRG.514.2_2 - 1.9e-26 90.8 59.2 2.8e-05 24.2 0.1 8.6 9 0 0 9 9 8 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.514.2_2 - 9.1e-26 89.0 40.6 5.5e-07 29.6 1.2 8.6 9 0 0 9 9 9 5 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.514.2_2 - 2.4e-23 80.6 56.7 0.0016 19.0 1.0 9.7 9 0 0 9 9 8 7 C2H2-type zinc finger zf-met PF12874.5 MSTRG.514.2_2 - 3.4e-16 58.9 37.9 0.0074 16.5 0.3 8.0 7 0 0 7 7 7 6 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.514.2_2 - 1.4e-12 47.4 45.0 0.00063 19.8 1.4 8.2 9 0 0 9 9 8 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 MSTRG.514.2_2 - 0.00072 19.3 41.7 0.084 12.7 1.9 8.1 8 0 0 8 8 8 4 C2H2-type zinc finger zf-C2HC_2 PF13913.4 MSTRG.514.2_2 - 0.001 18.8 35.1 0.18 11.7 0.1 7.6 7 0 0 7 7 7 3 zinc-finger of a C2HC-type zf-C2H2_2 PF12756.5 MSTRG.514.2_2 - 0.014 15.6 31.2 1.4 9.1 1.7 7.0 3 3 4 7 7 7 0 C2H2 type zinc-finger (2 copies) DUF3268 PF11672.6 MSTRG.514.2_2 - 0.15 12.3 13.2 0.89 9.8 0.5 3.4 3 0 0 3 3 3 0 zinc-finger-containing domain zf-C2HE PF16278.3 MSTRG.514.2_2 - 0.28 11.6 27.9 1 9.7 0.6 6.4 3 3 3 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger BolA PF01722.16 MSTRG.514.2_2 - 1.6 8.9 8.4 43 4.4 0.0 4.3 4 0 0 4 4 4 0 BolA-like protein zf-C2H2_11 PF16622.3 MSTRG.514.2_2 - 2 8.1 32.6 2.8 7.6 0.1 7.4 7 0 0 7 7 7 0 zinc-finger C2H2-type Desulfoferrod_N PF06397.10 MSTRG.514.2_2 - 2.3 7.8 13.5 3.9 7.1 0.2 4.6 4 0 0 4 4 4 0 Desulfoferrodoxin, N-terminal domain PHF5 PF03660.12 MSTRG.514.2_2 - 5 7.2 15.8 5.7 7.1 2.1 3.9 4 0 0 4 4 3 0 PHF5-like protein IRK PF01007.18 MSTRG.971.1_1 - 1.6e-126 421.6 0.7 2e-126 421.3 0.7 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 MSTRG.971.1_1 - 0.0039 17.0 6.1 0.011 15.5 6.1 1.8 1 0 0 1 1 1 1 Ion channel LRR_8 PF13855.4 MSTRG.13880.1_3 - 3e-36 122.9 26.8 4.6e-11 42.2 6.9 6.3 4 2 2 6 6 6 6 Leucine rich repeat LRR_4 PF12799.5 MSTRG.13880.1_3 - 1.8e-19 69.3 29.5 2.8e-05 24.2 2.2 7.3 4 2 4 8 8 8 7 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 MSTRG.13880.1_3 - 6.3e-07 28.8 19.8 0.38 10.8 1.1 7.9 7 1 0 8 8 8 2 Leucine Rich repeat LRR_9 PF14580.4 MSTRG.13880.1_3 - 1.5e-06 27.7 8.8 0.00032 20.1 1.1 3.8 1 1 3 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.31 MSTRG.13880.1_3 - 0.00069 19.6 24.1 2 9.1 0.8 9.1 8 2 1 9 9 9 1 Leucine Rich Repeat LRR_5 PF13306.4 MSTRG.13880.1_3 - 0.0015 18.4 0.1 3.5 7.5 0.0 2.9 1 1 1 3 3 3 2 Leucine rich repeats (6 copies) LRRNT PF01462.16 MSTRG.13880.1_3 - 0.013 15.0 10.4 0.074 12.6 5.6 3.1 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain Pentapeptide_4 PF13599.4 MSTRG.13880.1_3 - 0.019 15.0 0.2 1.5 8.9 0.1 2.4 2 0 0 2 2 2 0 Pentapeptide repeats (9 copies) Pkinase PF00069.23 MSTRG.9295.1_2 - 1.1e-69 234.6 0.0 1.4e-69 234.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.9295.1_2 - 1.3e-29 103.1 0.1 1.9e-29 102.6 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 MSTRG.9295.1_2 - 0.0011 18.8 0.1 0.0048 16.7 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.12 MSTRG.9295.1_2 - 0.012 14.8 0.1 0.019 14.2 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 MSTRG.9295.1_2 - 0.13 11.4 0.0 0.29 10.3 0.0 1.5 1 1 0 1 1 1 0 Kinase-like MEIOC PF15189.4 MSTRG.5234.2_3 - 8e-42 142.5 0.0 5.6e-41 139.8 0.0 2.3 3 0 0 3 3 3 1 Meiosis-specific coiled-coil domain-containing protein MEIOC C2 PF00168.28 MSTRG.15317.1_1 - 2.3e-10 40.6 0.2 5.7e-10 39.3 0.1 1.7 2 0 0 2 2 2 1 C2 domain Na_Ca_ex PF01699.22 MSTRG.8893.2_3 - 1.8e-24 86.3 11.9 2.7e-24 85.7 11.9 1.3 1 0 0 1 1 1 1 Sodium/calcium exchanger protein LRR_8 PF13855.4 MSTRG.29688.1_3 - 4.7e-20 71.0 9.3 2.6e-13 49.4 1.0 3.5 3 1 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.5 MSTRG.29688.1_3 - 8.8e-17 60.7 13.0 1.6e-06 28.1 0.1 4.0 2 2 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 MSTRG.29688.1_3 - 1e-07 31.5 0.6 5.9e-05 22.5 0.1 2.2 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.31 MSTRG.29688.1_3 - 1.6e-06 27.6 13.0 0.66 10.5 0.2 6.1 5 1 0 5 5 5 2 Leucine Rich Repeat LRR_6 PF13516.4 MSTRG.29688.1_3 - 2e-05 24.2 10.1 2.5 8.3 0.1 5.4 5 0 0 5 5 5 3 Leucine Rich repeat CSTF_C PF14304.4 MSTRG.29688.1_3 - 0.12 11.8 4.0 24 4.4 0.1 3.6 3 0 0 3 3 3 0 Transcription termination and cleavage factor C-terminal Pkinase PF00069.23 MSTRG.13576.3_2 - 4e-73 245.9 0.0 4.9e-73 245.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.13576.3_2 - 9e-34 116.8 0.0 1.2e-33 116.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.13576.3_2 - 1.7e-08 34.0 0.0 2.7e-08 33.4 0.0 1.4 1 1 0 1 1 1 1 Kinase-like APH PF01636.21 MSTRG.13576.3_2 - 0.15 11.9 0.1 2.8 7.7 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family WGR PF05406.13 MSTRG.13576.3_2 - 0.23 11.4 1.5 46 4.0 0.0 3.3 3 0 0 3 3 3 0 WGR domain p450 PF00067.20 MSTRG.8257.1_3 - 8.1e-138 459.9 0.1 1.1e-137 459.5 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.23 MSTRG.4467.1_1 - 2.6e-22 79.3 0.0 3.7e-22 78.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.4467.1_1 - 1.5e-05 24.3 0.1 2.6e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PDZ PF00595.22 MSTRG.22134.1_3 - 6.1e-39 132.1 6.6 5.8e-18 64.9 0.4 3.3 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.22134.1_3 - 9.6e-17 61.0 2.7 4.9e-05 23.4 0.2 3.4 3 0 0 3 3 3 3 PDZ domain DUF3567 PF12091.6 MSTRG.22134.1_3 - 0.015 15.3 0.0 0.038 14.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3567) Baculo_LEF5_C PF11792.6 MSTRG.22134.1_3 - 0.039 13.5 0.1 0.12 11.9 0.1 1.9 1 0 0 1 1 1 0 Baculoviridae late expression factor 5 C-terminal domain Tricorn_PDZ PF14685.4 MSTRG.22134.1_3 - 0.16 11.9 4.2 3.4 7.6 0.2 3.3 3 1 1 4 4 4 0 Tricorn protease PDZ domain CMD PF02627.18 MSTRG.15809.1_2 - 2.1e-13 50.0 0.3 1e-09 38.2 0.0 2.3 1 1 1 2 2 2 2 Carboxymuconolactone decarboxylase family PBC PF03792.11 MSTRG.3696.4_1 - 3.6e-89 297.4 0.1 6e-89 296.7 0.1 1.4 1 0 0 1 1 1 1 PBC domain Homeobox PF00046.27 MSTRG.3696.4_1 - 1.7e-19 69.2 0.7 3.3e-19 68.3 0.7 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 MSTRG.3696.4_1 - 1.4e-16 59.9 0.0 1e-15 57.2 0.0 2.3 2 0 0 2 2 2 1 Homeobox KN domain YdaS_antitoxin PF15943.3 MSTRG.3696.4_1 - 0.0074 16.0 0.0 0.017 14.8 0.0 1.6 1 0 0 1 1 1 1 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_3 PF01381.20 MSTRG.3696.4_1 - 0.081 12.9 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix Crystall PF00030.17 MSTRG.8345.2_2 - 2.2e-117 383.3 0.0 3.9e-19 68.5 0.0 6.6 6 0 0 6 6 6 6 Beta/Gamma crystallin Ricin_B_lectin PF00652.20 MSTRG.8345.2_2 - 5.5e-07 29.8 0.0 1.2e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Toxin_11 PF07473.9 MSTRG.11256.1_1 - 0.96 9.5 9.7 0.38 10.7 1.9 2.3 2 0 0 2 2 2 0 Spasmodic peptide gm9a; conotoxin from Conus species DUF3657 PF12394.6 MSTRG.11256.1_3 - 2.1e-19 69.6 2.3 2.7e-19 69.3 2.3 1.1 1 0 0 1 1 1 1 Protein FAM135 WBS_methylT PF12589.6 MSTRG.17949.1_2 - 9.5e-21 74.2 4.7 1.5e-20 73.5 4.7 1.3 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.10 MSTRG.17949.1_2 - 2.3e-12 47.3 0.0 3.7e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 MSTRG.17949.1_2 - 3.5e-11 43.6 0.0 6.9e-11 42.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 MSTRG.17949.1_2 - 0.00033 21.2 0.0 0.00074 20.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 MSTRG.17949.1_2 - 0.00062 19.5 0.0 0.001 18.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 MSTRG.17949.1_2 - 0.0043 16.9 0.0 0.0069 16.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.4 MSTRG.17949.1_2 - 0.0086 15.9 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.18 MSTRG.17949.1_2 - 0.029 13.5 0.0 0.045 12.9 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase AdoMet_MTase PF07757.11 MSTRG.17949.1_2 - 0.15 12.3 0.1 0.49 10.6 0.1 1.8 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase TehB PF03848.12 MSTRG.17949.1_2 - 0.17 11.1 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB MAP65_ASE1 PF03999.10 MSTRG.25058.1_1 - 3.8e-141 471.6 32.1 4.9e-141 471.2 32.1 1.1 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) GMC_oxred_N PF00732.17 MSTRG.25058.1_1 - 0.19 10.9 1.0 0.35 10.1 1.0 1.4 1 0 0 1 1 1 0 GMC oxidoreductase FAM167 PF11652.6 MSTRG.25058.1_1 - 5.5 7.4 11.9 0.38 11.1 0.4 3.8 4 0 0 4 4 4 0 FAM167 EzrA PF06160.10 MSTRG.29723.1_1 - 0.0008 17.6 11.5 0.0008 17.6 11.5 3.1 1 1 2 3 3 3 1 Septation ring formation regulator, EzrA DUF3584 PF12128.6 MSTRG.29723.1_1 - 0.25 8.7 54.0 0.0094 13.4 15.3 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF3584) TPR_MLP1_2 PF07926.10 MSTRG.29723.1_1 - 1.3 9.0 72.8 0.034 14.1 14.8 4.5 1 1 3 4 4 4 0 TPR/MLP1/MLP2-like protein DASH_Dam1 PF08653.8 MSTRG.29723.1_1 - 1.9 8.2 10.8 10 5.8 0.2 4.7 3 1 1 4 4 4 0 DASH complex subunit Dam1 Fez1 PF06818.13 MSTRG.29723.1_1 - 2 8.7 57.5 0.61 10.4 18.9 3.1 1 1 2 3 3 3 0 Fez1 CtIP_N PF10482.7 MSTRG.29723.1_1 - 2.3 8.2 38.1 0.094 12.7 3.1 4.0 1 1 2 4 4 4 0 Tumour-suppressor protein CtIP N-terminal domain Filament PF00038.19 MSTRG.29723.1_1 - 2.8 7.3 55.0 0.11 12.0 26.6 2.6 1 1 0 2 2 2 0 Intermediate filament protein Spc7 PF08317.9 MSTRG.29723.1_1 - 3.3 6.4 63.1 0.59 8.8 14.7 3.2 1 1 1 3 3 3 0 Spc7 kinetochore protein Atg14 PF10186.7 MSTRG.29723.1_1 - 5.8 5.8 52.5 0.54 9.2 13.8 3.2 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fib_alpha PF08702.8 MSTRG.29723.1_1 - 6.5 6.8 37.9 0.64 10.1 3.6 3.8 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family RTC PF01137.19 MSTRG.47.1_1 - 5.1e-57 192.5 0.0 6.8e-57 192.0 0.0 1.2 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.11 MSTRG.47.1_1 - 1e-35 122.3 0.0 1.8e-35 121.5 0.0 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain AF-4 PF05110.11 MSTRG.47.1_2 - 3.4e-212 707.7 115.1 1.1e-119 401.3 28.6 4.8 1 1 2 3 3 3 3 AF-4 proto-oncoprotein CUB PF00431.18 MSTRG.17050.1_3 - 3.5e-22 78.7 0.0 6e-22 77.9 0.0 1.4 1 0 0 1 1 1 1 CUB domain PDGF PF00341.15 MSTRG.17050.1_3 - 2.1e-13 50.2 5.2 3.7e-13 49.4 5.2 1.4 1 0 0 1 1 1 1 PDGF/VEGF domain DnaJ PF00226.29 MSTRG.18845.1_1 - 1.1e-15 57.3 1.1 3.3e-15 55.8 1.1 1.9 1 0 0 1 1 1 1 DnaJ domain BSD PF03909.15 MSTRG.5356.1_3 - 1.4e-12 47.3 1.4 1.4e-12 47.3 1.4 2.6 3 0 0 3 3 3 1 BSD domain IFT20 PF14931.4 MSTRG.5356.1_3 - 0.083 12.9 0.4 0.083 12.9 0.4 3.4 4 0 0 4 4 4 0 Intraflagellar transport complex B, subunit 20 Presenilin PF01080.15 MSTRG.5356.1_3 - 7 5.2 8.3 0.24 10.0 0.3 2.1 2 0 0 2 2 2 0 Presenilin Lipocalin PF00061.21 MSTRG.8633.1_3 - 1.1e-20 74.2 0.0 1.3e-20 74.0 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Triabin PF03973.11 MSTRG.8633.1_3 - 0.031 14.0 0.1 0.062 13.0 0.1 1.5 1 0 0 1 1 1 0 Triabin SH3_1 PF00018.26 MSTRG.24029.1_1 - 1.7e-13 49.8 0.1 2.7e-13 49.2 0.1 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.24029.1_1 - 2.6e-12 46.3 0.1 4.4e-12 45.5 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.24029.1_1 - 1.7e-10 40.3 0.0 3.1e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DNAPolymera_Pol PF11590.6 MSTRG.925.1_1 - 0.5 10.2 3.5 6.8 6.5 0.3 2.5 2 0 0 2 2 2 0 DNA polymerase catalytic subunit Pol RhoGEF PF00621.18 MSTRG.925.1_2 - 1.5e-20 74.1 0.8 1.5e-20 74.1 0.8 2.1 2 0 0 2 2 2 1 RhoGEF domain IL13 PF03487.11 MSTRG.925.1_2 - 0.048 13.4 0.2 1.8 8.3 0.0 2.4 2 0 0 2 2 2 0 Interleukin-13 7tm_1 PF00001.19 MSTRG.6853.1_1 - 2e-22 79.6 0.5 2.5e-22 79.2 0.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 MSTRG.6853.1_1 - 0.0035 16.6 0.6 0.0049 16.1 0.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DDDD PF10161.7 MSTRG.7974.1_2 - 5.4e-34 115.7 0.0 9.7e-34 114.8 0.0 1.4 1 0 0 1 1 1 1 Putative mitochondrial precursor protein Dak1 PF02733.15 MSTRG.24521.1_2 - 2.3e-109 364.8 1.3 3.2e-109 364.4 1.3 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.15 MSTRG.24521.1_2 - 7.1e-43 146.4 5.2 7.1e-43 146.4 5.2 1.7 2 0 0 2 2 2 1 DAK2 domain TM2 PF05154.14 MSTRG.24342.3_3 - 2.5e-16 59.6 5.5 5.1e-16 58.6 5.5 1.5 1 0 0 1 1 1 1 TM2 domain Sec62 PF03839.14 MSTRG.29225.1_1 - 3.6e-44 150.7 2.8 4.1e-44 150.6 2.8 1.0 1 0 0 1 1 1 1 Translocation protein Sec62 DUF2207 PF09972.7 MSTRG.29225.1_1 - 0.0024 16.6 0.4 0.0028 16.4 0.4 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) RNA_pol_Rpc4 PF05132.12 MSTRG.29225.1_1 - 0.056 13.8 8.1 0.08 13.3 8.1 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 ALMT PF11744.6 MSTRG.29225.1_1 - 0.086 11.5 0.1 0.11 11.2 0.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Dsh_C PF12316.6 MSTRG.29225.1_1 - 0.13 12.5 0.0 0.15 12.4 0.0 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal V_ATPase_I PF01496.17 MSTRG.29225.1_1 - 0.24 9.1 2.3 0.23 9.2 2.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CDC45 PF02724.12 MSTRG.29225.1_1 - 0.28 9.3 9.4 0.32 9.1 9.4 1.0 1 0 0 1 1 1 0 CDC45-like protein SpoIIP PF07454.9 MSTRG.29225.1_1 - 0.44 9.8 7.9 0.58 9.4 7.9 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF913 PF06025.10 MSTRG.29225.1_1 - 0.84 8.4 5.0 1 8.1 5.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) eIF-3c_N PF05470.10 MSTRG.29225.1_1 - 1 7.4 10.8 1.2 7.2 10.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DUF2201_N PF13203.4 MSTRG.29225.1_1 - 1.2 8.5 4.2 1.5 8.2 4.2 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain RR_TM4-6 PF06459.10 MSTRG.29225.1_1 - 1.6 8.3 12.1 2 8.0 12.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CobT PF06213.10 MSTRG.29225.1_1 - 1.6 7.9 10.4 2 7.6 10.4 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Vfa1 PF08432.8 MSTRG.29225.1_1 - 2.9 8.1 21.7 3.8 7.7 21.7 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Rtf2 PF04641.10 MSTRG.29225.1_1 - 3.4 6.8 18.8 4.4 6.5 18.8 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Integrin_B_tail PF07965.10 MSTRG.15467.1_3 - 1.7e-24 86.0 8.3 1.7e-24 86.0 8.3 2.6 3 0 0 3 3 3 1 Integrin beta tail domain Integrin_b_cyt PF08725.9 MSTRG.15467.1_3 - 2.4e-23 81.4 0.1 4.2e-23 80.6 0.1 1.4 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain EGF_2 PF07974.11 MSTRG.15467.1_3 - 2.4e-07 30.8 30.5 2.6e-06 27.5 12.1 3.2 3 0 0 3 3 3 2 EGF-like domain Snf7 PF03357.19 MSTRG.5225.3_2 - 1.3e-50 171.3 13.4 1.6e-50 170.9 13.4 1.1 1 0 0 1 1 1 1 Snf7 DUF155 PF02582.12 MSTRG.5225.3_2 - 0.03 14.3 1.9 0.044 13.7 1.9 1.2 1 0 0 1 1 1 0 Uncharacterised ACR, YagE family COG1723 DNA_pol_B_thumb PF14791.4 MSTRG.6706.1_3 - 0.085 12.9 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase beta thumb Lectin_C PF00059.19 MSTRG.1039.1_2 - 1e-20 74.3 0.2 2e-20 73.4 0.2 1.5 1 0 0 1 1 1 1 Lectin C-type domain Wzz PF02706.13 MSTRG.1039.1_2 - 0.0045 16.9 0.2 0.0062 16.5 0.2 1.2 1 0 0 1 1 1 1 Chain length determinant protein HemX PF04375.12 MSTRG.1039.1_2 - 0.02 14.1 2.4 0.029 13.5 2.4 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Reo_sigmaC PF04582.10 MSTRG.1039.1_2 - 0.04 13.2 3.3 0.058 12.7 3.3 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF4094 PF13334.4 MSTRG.1039.1_2 - 0.081 13.2 1.1 0.19 12.0 1.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) Bacillus_HBL PF05791.9 MSTRG.1039.1_2 - 0.11 12.1 0.8 4.8 6.8 0.7 2.1 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Mnd1 PF03962.13 MSTRG.1039.1_2 - 0.13 12.0 1.8 0.19 11.4 1.8 1.1 1 0 0 1 1 1 0 Mnd1 family FlaC_arch PF05377.9 MSTRG.1039.1_2 - 0.26 11.6 1.0 4.7 7.5 1.0 2.3 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) Sec8_exocyst PF04048.12 MSTRG.1039.1_2 - 0.3 10.9 3.7 1.1 9.1 3.1 1.9 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain Y_phosphatase PF00102.25 MSTRG.15519.1_3 - 2.2e-36 125.5 0.3 2.5e-36 125.3 0.3 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase LRR_4 PF12799.5 MSTRG.11113.4_3 - 1.7e-19 69.4 32.2 2.3e-07 30.9 3.1 3.9 1 1 4 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 MSTRG.11113.4_3 - 3e-17 62.0 15.4 1.4e-09 37.4 5.5 2.7 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.31 MSTRG.11113.4_3 - 3.5e-08 32.6 10.3 1.4 9.6 0.1 5.9 6 0 0 6 6 6 4 Leucine Rich Repeat LRR_6 PF13516.4 MSTRG.11113.4_3 - 1.6e-05 24.5 14.1 2.7 8.2 0.0 5.4 5 0 0 5 5 5 4 Leucine Rich repeat RsmF_methylt_CI PF17126.3 MSTRG.11113.4_3 - 0.032 14.2 0.1 13 5.8 0.0 3.0 1 1 2 3 3 3 0 RsmF rRNA methyltransferase first C-terminal domain DAGK_acc PF00609.17 MSTRG.8076.2_1 - 1.2e-30 106.9 0.0 2.1e-30 106.1 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.22 MSTRG.8076.2_1 - 1e-23 83.2 0.0 2.4e-23 82.0 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.20 MSTRG.8076.2_1 - 4.2e-21 74.4 49.9 3.5e-11 42.7 7.9 3.7 3 1 0 3 3 3 3 Phorbol esters/diacylglycerol binding domain (C1 domain) RA PF00788.21 MSTRG.8076.2_1 - 6.1e-16 58.7 0.0 2.6e-07 31.0 0.2 3.0 3 0 0 3 3 3 2 Ras association (RalGDS/AF-6) domain SNF2_N PF00176.21 MSTRG.8976.1_3 - 0.088 11.4 0.2 0.14 10.8 0.2 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain BTB_2 PF02214.20 MSTRG.14833.1_3 - 1.3e-13 51.0 0.0 2.3e-13 50.2 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Myosin_head PF00063.19 MSTRG.19594.3_2 - 1.6e-143 479.3 0.2 1.8e-143 479.1 0.2 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) CRIM PF16978.3 MSTRG.2285.2_1 - 2.3e-35 121.7 0.0 4.1e-35 120.8 0.0 1.4 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.3 MSTRG.2285.2_1 - 6.2e-30 103.6 0.5 1.1e-29 102.8 0.5 1.4 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology SIN1 PF05422.10 MSTRG.2285.2_1 - 3.9e-25 88.9 2.7 7.7e-25 88.0 0.6 2.2 2 0 0 2 2 2 1 Stress-activated map kinase interacting protein 1 (SIN1) Ank_2 PF12796.5 MSTRG.7098.1_2 - 7.1e-08 32.8 0.4 2.3e-07 31.1 0.4 1.8 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.7098.1_2 - 2.4e-07 30.8 1.3 0.0018 18.4 0.1 3.2 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.4 MSTRG.7098.1_2 - 1.8e-05 25.1 0.1 0.098 13.1 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.7098.1_2 - 0.00024 21.2 0.7 3.8 8.2 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat DUF2465 PF10239.7 MSTRG.14598.1_3 - 3.3e-125 417.5 0.0 4e-125 417.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2465) RhoGEF PF00621.18 MSTRG.9560.2_3 - 2.3e-33 115.8 0.8 2.3e-33 115.8 0.8 3.2 3 0 0 3 3 3 1 RhoGEF domain PH_10 PF15411.4 MSTRG.9560.2_3 - 0.034 14.3 1.5 0.35 11.0 0.2 2.7 1 1 1 2 2 2 0 Pleckstrin homology domain PH PF00169.27 MSTRG.9560.2_3 - 0.1 13.0 0.1 0.36 11.2 0.1 2.0 1 0 0 1 1 1 0 PH domain Cadherin PF00028.15 MSTRG.16145.1_1 - 1.5e-103 339.3 0.3 4.2e-19 68.6 0.0 7.2 7 0 0 7 7 7 6 Cadherin domain Cadherin_3 PF16184.3 MSTRG.16145.1_1 - 1.4e-08 34.6 0.9 0.0052 16.7 0.0 5.2 5 0 0 5 5 5 2 Cadherin-like Cadherin_2 PF08266.10 MSTRG.16145.1_1 - 6.5e-06 25.7 0.0 11 5.8 0.0 6.1 6 0 0 6 6 6 2 Cadherin-like Y_Y_Y PF07495.11 MSTRG.16145.1_1 - 0.0026 17.5 0.0 0.18 11.7 0.0 2.9 2 0 0 2 2 2 1 Y_Y_Y domain DUF4958 PF16319.3 MSTRG.16145.1_1 - 0.014 13.4 0.4 1.3 6.8 0.1 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4958) TUG-UBL1 PF11470.6 MSTRG.19089.2_2 - 4.6e-23 81.1 0.5 1.3e-22 79.7 0.5 1.8 1 0 0 1 1 1 1 TUG ubiquitin-like domain UBX PF00789.18 MSTRG.19089.2_2 - 2.4e-09 37.1 0.0 8.8e-05 22.5 0.0 3.2 3 0 0 3 3 3 2 UBX domain RBD PF02196.13 MSTRG.19089.2_2 - 0.0013 18.7 0.1 0.004 17.1 0.1 1.8 1 0 0 1 1 1 1 Raf-like Ras-binding domain Angiomotin_C PF12240.6 MSTRG.28797.1_1 - 1.3e-13 50.9 4.4 1.3e-13 50.9 4.4 2.2 2 0 0 2 2 2 1 Angiomotin C terminal UPF0449 PF15136.4 MSTRG.28797.1_1 - 0.2 12.0 12.0 0.21 11.9 7.4 2.0 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 CENP-K PF11802.6 MSTRG.28797.1_1 - 0.23 10.9 8.7 0.27 10.7 8.7 1.1 1 0 0 1 1 1 0 Centromere-associated protein K APG6 PF04111.10 MSTRG.28797.1_1 - 0.72 9.1 14.3 0.8 8.9 14.3 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 PRTP PF01366.16 MSTRG.28797.1_1 - 1.1 7.0 6.5 1.4 6.8 6.5 1.0 1 0 0 1 1 1 0 Herpesvirus processing and transport protein Mnd1 PF03962.13 MSTRG.28797.1_1 - 1.3 8.7 13.8 1.5 8.5 13.8 1.1 1 0 0 1 1 1 0 Mnd1 family DUF724 PF05266.12 MSTRG.28797.1_1 - 1.6 8.4 9.4 1.9 8.1 9.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) PRR20 PF15708.3 MSTRG.28797.1_1 - 1.8 8.4 5.8 2.1 8.2 5.8 1.2 1 0 0 1 1 1 0 Proline-rich protein family 20 Nup88 PF10168.7 MSTRG.28797.1_1 - 3.3 5.3 10.6 3.9 5.0 10.6 1.0 1 0 0 1 1 1 0 Nuclear pore component FUSC PF04632.10 MSTRG.28797.1_1 - 4.9 5.4 11.1 5.3 5.3 11.1 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4192 PF13830.4 MSTRG.28797.1_1 - 5 6.9 12.8 5.4 6.8 12.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) PEP-utilisers_N PF05524.11 MSTRG.28797.1_1 - 5.6 7.0 14.3 22 5.1 1.2 2.6 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal Atg14 PF10186.7 MSTRG.28797.1_1 - 5.6 5.8 12.8 6.3 5.6 12.8 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 IncA PF04156.12 MSTRG.28797.1_1 - 7.6 6.1 17.0 9.9 5.8 17.0 1.1 1 0 0 1 1 1 0 IncA protein GvpL_GvpF PF06386.9 MSTRG.28797.1_1 - 7.7 6.2 13.0 9.5 5.9 13.0 1.1 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF DUF342 PF03961.11 MSTRG.28797.1_1 - 8.7 4.7 7.6 9.8 4.5 7.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) MyTH4 PF00784.15 MSTRG.19874.1_1 - 8.8e-37 125.7 3.0 2.2e-36 124.4 3.0 1.8 1 0 0 1 1 1 1 MyTH4 domain FERM_M PF00373.16 MSTRG.19874.1_1 - 3.2e-14 53.2 0.0 8.5e-14 51.8 0.0 1.7 1 0 0 1 1 1 1 FERM central domain PH PF00169.27 MSTRG.19874.1_1 - 8.5e-10 39.0 0.0 5.7e-06 26.7 0.0 2.7 2 0 0 2 2 2 2 PH domain CHGN PF05679.14 MSTRG.14735.1_3 - 4.6e-47 160.9 0.3 6.7e-47 160.4 0.3 1.1 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase IncA PF04156.12 MSTRG.14735.1_3 - 0.041 13.5 3.0 0.097 12.3 3.0 1.6 1 0 0 1 1 1 0 IncA protein zf-H2C2_2 PF13465.4 MSTRG.5399.1_3 - 1.4e-31 107.4 51.2 1.1e-06 28.6 1.8 8.0 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.5399.1_3 - 1e-25 88.5 47.3 0.00039 20.6 1.2 8.0 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.5399.1_3 - 4.9e-20 70.4 51.4 0.0094 16.6 1.3 8.0 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.5399.1_3 - 3.1e-12 46.4 23.2 0.035 14.3 0.2 7.2 7 0 0 7 7 7 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.5399.1_3 - 5.5e-06 26.5 31.6 0.046 14.0 0.4 6.9 6 0 0 6 6 6 4 Zinc-finger of C2H2 type zf-Di19 PF05605.10 MSTRG.5399.1_3 - 0.0035 17.5 30.2 0.13 12.4 9.5 5.4 2 1 1 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.4 MSTRG.5399.1_3 - 0.0063 16.3 42.4 0.035 13.9 0.4 7.4 7 0 0 7 7 7 5 C2H2-type zinc finger zf-C2H2_11 PF16622.3 MSTRG.5399.1_3 - 0.015 14.9 31.9 0.98 9.1 0.5 6.7 6 0 0 6 6 6 0 zinc-finger C2H2-type zf-H2C2_5 PF13909.4 MSTRG.5399.1_3 - 0.31 10.7 20.7 16 5.3 0.0 6.5 5 0 0 5 5 5 0 C2H2-type zinc-finger domain zinc_ribbon_9 PF14369.4 MSTRG.5399.1_3 - 0.49 10.6 15.6 1.6 8.9 0.1 5.9 5 1 0 5 5 5 0 zinc-ribbon GAGA PF09237.9 MSTRG.5399.1_3 - 0.58 9.9 5.3 7.2 6.4 0.3 3.9 2 1 2 4 4 4 0 GAGA factor zinc_ribbon_15 PF17032.3 MSTRG.5399.1_3 - 2.7 8.7 14.1 64 4.3 0.4 5.2 3 1 1 4 4 4 0 zinc-ribbon family Ion_trans PF00520.29 MSTRG.20271.1_2 - 2.9e-50 170.6 9.6 2.9e-50 170.6 9.6 2.1 2 0 0 2 2 2 1 Ion transport protein BTB_2 PF02214.20 MSTRG.20271.1_2 - 4.9e-28 97.2 0.0 9.6e-28 96.2 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 MSTRG.20271.1_2 - 1.7e-13 50.2 4.6 1.7e-13 50.2 4.6 2.2 2 0 0 2 2 2 1 Ion channel PKD_channel PF08016.10 MSTRG.20271.1_2 - 0.016 13.8 0.6 0.027 13.0 0.6 1.3 1 0 0 1 1 1 0 Polycystin cation channel I-set PF07679.14 MSTRG.13524.1_1 - 7.4e-112 365.6 13.7 9.8e-13 47.9 0.0 9.7 10 0 0 10 10 10 9 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.13524.1_1 - 1.1e-78 259.8 9.5 5e-10 39.7 0.0 9.3 9 0 0 9 9 9 9 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.13524.1_1 - 9.8e-68 224.4 9.8 7.1e-09 35.8 0.1 9.1 6 3 3 9 9 9 8 Immunoglobulin domain ig PF00047.23 MSTRG.13524.1_1 - 3e-66 219.5 26.6 7.6e-10 38.7 0.0 9.7 10 0 0 10 10 10 8 Immunoglobulin domain V-set PF07686.15 MSTRG.13524.1_1 - 2.6e-38 130.4 41.5 0.00022 21.2 0.3 16.7 10 8 3 13 13 13 10 Immunoglobulin V-set domain Ig_5 PF16681.3 MSTRG.13524.1_1 - 8e-27 93.4 13.4 0.0081 16.4 0.0 9.0 8 0 0 8 8 8 8 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 MSTRG.13524.1_1 - 4e-17 61.9 22.0 0.094 12.6 0.0 10.9 10 4 1 11 11 11 8 Izumo-like Immunoglobulin domain Ig_4 PF16680.3 MSTRG.13524.1_1 - 5.2e-15 55.4 20.7 0.11 12.8 0.1 10.1 8 4 0 8 8 8 5 T-cell surface glycoprotein CD3 delta chain Receptor_2B4 PF11465.6 MSTRG.13524.1_1 - 0.00051 20.1 0.0 6.3 6.9 0.0 5.5 7 1 1 8 8 8 1 Natural killer cell receptor 2B4 ATP-grasp PF02222.20 MSTRG.13524.1_1 - 0.1 12.1 0.0 14 5.1 0.0 2.5 2 0 0 2 2 2 0 ATP-grasp domain DUF3409 PF11889.6 MSTRG.13524.1_1 - 0.67 9.8 2.6 25 4.7 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF3409) Ig_3 PF13927.4 MSTRG.9081.1_2 - 1.8e-06 28.4 0.1 3.9e-06 27.2 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 MSTRG.9081.1_2 - 0.0041 17.0 0.0 0.0077 16.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain OB_NTP_bind PF07717.14 MSTRG.19651.2_2 - 2.4e-17 63.0 0.1 1.2e-16 60.7 0.0 2.1 1 1 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.21 MSTRG.19651.2_2 - 2.9e-16 59.5 0.7 9.2e-16 57.9 0.1 2.3 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.29 MSTRG.19651.2_2 - 7.1e-15 55.2 0.0 2e-14 53.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.27 MSTRG.19651.2_2 - 3.2e-10 39.9 0.0 6.5e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.4 MSTRG.19651.2_2 - 0.00012 22.2 0.2 0.00046 20.3 0.2 2.0 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.18 MSTRG.19651.2_2 - 0.0032 16.4 0.0 0.0078 15.2 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein ATPase PF06745.11 MSTRG.19651.2_2 - 0.047 12.9 0.0 0.11 11.7 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_29 PF13555.4 MSTRG.19651.2_2 - 0.13 11.8 0.0 0.32 10.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain WRC PF08879.8 MSTRG.19651.2_2 - 0.69 9.6 6.3 10 5.9 0.2 3.0 3 0 0 3 3 3 0 WRC NinE PF05322.9 MSTRG.19651.2_2 - 1.7 8.5 3.8 17 5.2 0.5 2.5 2 0 0 2 2 2 0 NINE Protein AAA_23 PF13476.4 MSTRG.19651.2_2 - 2 8.7 0.0 2 8.7 0.0 3.2 2 1 1 3 3 3 0 AAA domain WD40 PF00400.30 MSTRG.3181.1_3 - 2.5e-40 135.6 20.3 6.1e-08 33.1 0.0 7.9 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.3181.1_3 - 4.1e-13 49.3 0.0 0.0014 18.7 0.0 5.3 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 MSTRG.3181.1_3 - 0.00028 20.2 0.0 0.0027 17.0 0.0 2.1 1 1 1 2 2 2 2 WD40-like domain Myc-LZ PF02344.13 MSTRG.3181.1_3 - 0.09 12.8 2.4 0.21 11.6 2.4 1.6 1 0 0 1 1 1 0 Myc leucine zipper domain CALM_bind PF16025.3 MSTRG.3181.1_3 - 0.12 12.7 2.3 0.36 11.1 1.7 1.9 2 0 0 2 2 2 0 Calcium-dependent calmodulin binding DUF4407 PF14362.4 MSTRG.3181.1_3 - 0.73 9.0 2.2 1.1 8.4 2.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3446 PF11928.6 MSTRG.25500.1_3 - 0.031 14.5 3.0 0.055 13.6 3.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) MIB_HERC2 PF06701.11 MSTRG.1328.3_1 - 1.2e-23 83.1 4.5 3.1e-23 81.7 4.5 1.8 1 0 0 1 1 1 1 Mib_herc2 Sad1_UNC PF07738.11 MSTRG.1328.3_1 - 4.5e-21 75.1 0.0 8.9e-21 74.2 0.0 1.5 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Ank_2 PF12796.5 MSTRG.1328.3_1 - 1.4e-19 70.3 0.0 1.9e-10 41.0 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.1328.3_1 - 2.8e-11 43.3 0.0 4.7e-07 29.9 0.0 3.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.1328.3_1 - 1.6e-09 37.7 0.0 0.00017 21.7 0.0 5.0 5 0 0 5 5 5 2 Ankyrin repeat Ank_3 PF13606.4 MSTRG.1328.3_1 - 4e-09 35.8 0.0 0.031 14.7 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.4 MSTRG.1328.3_1 - 6.3e-09 36.1 0.0 1.9e-06 28.2 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) F5_F8_type_C PF00754.23 MSTRG.1328.3_1 - 3.7e-05 23.7 0.3 0.00013 21.9 0.3 1.9 1 0 0 1 1 1 1 F5/8 type C domain ABC_membrane PF00664.21 MSTRG.6515.2_1 - 4.8e-131 436.3 20.8 2.7e-68 230.5 6.2 2.5 2 1 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 MSTRG.6515.2_1 - 2.4e-67 225.5 0.0 8.1e-33 113.7 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 MSTRG.6515.2_1 - 8.6e-12 44.8 0.0 1.3e-05 24.7 0.0 2.8 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain DUF258 PF03193.14 MSTRG.6515.2_1 - 6.9e-08 32.4 0.0 0.0045 16.8 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.4 MSTRG.6515.2_1 - 1.3e-07 32.1 0.2 0.028 14.6 0.1 2.9 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.4 MSTRG.6515.2_1 - 7.9e-06 26.0 0.1 0.016 15.3 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.4 MSTRG.6515.2_1 - 1.6e-05 24.4 0.1 0.034 13.7 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.4 MSTRG.6515.2_1 - 0.0001 21.9 0.0 0.37 10.2 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain Zeta_toxin PF06414.10 MSTRG.6515.2_1 - 0.00029 20.1 0.3 0.031 13.4 0.0 2.8 3 0 0 3 3 3 1 Zeta toxin AAA_30 PF13604.4 MSTRG.6515.2_1 - 0.00039 20.1 0.6 0.59 9.7 0.0 3.2 3 1 0 3 3 3 2 AAA domain ABC_ATPase PF09818.7 MSTRG.6515.2_1 - 0.0021 16.8 0.3 0.57 8.8 0.1 2.4 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_33 PF13671.4 MSTRG.6515.2_1 - 0.011 15.7 0.1 4.4 7.3 0.0 2.8 3 0 0 3 3 3 0 AAA domain SbcCD_C PF13558.4 MSTRG.6515.2_1 - 0.011 15.8 0.8 1.6 8.9 0.0 3.2 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF87 PF01935.15 MSTRG.6515.2_1 - 0.016 15.1 0.0 8.5 6.2 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function DUF87 G-alpha PF00503.18 MSTRG.6515.2_1 - 0.017 14.1 0.0 3.1 6.7 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit AAA_28 PF13521.4 MSTRG.6515.2_1 - 0.02 15.0 0.0 13 5.9 0.0 3.3 3 0 0 3 3 3 0 AAA domain DUF815 PF05673.11 MSTRG.6515.2_1 - 0.022 13.8 0.1 1.8 7.5 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF815) AAA_21 PF13304.4 MSTRG.6515.2_1 - 0.035 13.8 0.1 2.2 7.9 0.0 2.8 2 1 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system ATP-synt_ab PF00006.23 MSTRG.6515.2_1 - 0.04 13.4 0.8 8.9 5.8 0.3 2.5 2 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain APS_kinase PF01583.18 MSTRG.6515.2_1 - 0.063 13.0 0.0 1.2 8.8 0.0 2.4 2 0 0 2 2 2 0 Adenylylsulphate kinase RNA_helicase PF00910.20 MSTRG.6515.2_1 - 0.084 13.1 0.1 15 5.9 0.0 3.0 3 0 0 3 3 2 0 RNA helicase Dala_Dala_lig_N PF01820.19 MSTRG.6515.2_1 - 0.09 12.8 0.0 7.6 6.6 0.0 2.8 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus SH3_2 PF07653.15 MSTRG.668.1_2 - 2.7e-23 81.3 0.0 4.7e-13 48.5 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_9 PF14604.4 MSTRG.668.1_2 - 1.1e-17 63.4 0.1 2e-10 40.2 0.1 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.26 MSTRG.668.1_2 - 1.1e-08 34.5 0.0 0.00034 20.0 0.1 2.9 2 1 0 2 2 2 2 SH3 domain Ribosomal_S18 PF01084.18 MSTRG.6771.1_2 - 7.1e-15 54.8 0.0 1.6e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S18 RRM_1 PF00076.20 MSTRG.20035.1_2 - 3.4e-87 286.1 1.1 1.2e-23 82.5 0.4 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 MSTRG.20035.1_2 - 1.7e-09 37.2 0.1 0.029 13.9 0.1 4.1 1 1 2 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 MSTRG.20035.1_2 - 5.1e-06 26.1 0.0 3.9 7.3 0.0 3.6 3 0 0 3 3 3 3 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.4 MSTRG.20035.1_2 - 0.00037 20.3 0.2 15 5.5 0.0 4.4 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.6 MSTRG.20035.1_2 - 0.0029 17.5 0.2 3.7 7.6 0.0 3.8 4 0 0 4 4 4 1 Limkain b1 RRM_3 PF08777.9 MSTRG.20035.1_2 - 0.004 17.1 2.1 1.2 9.0 0.1 3.3 3 0 0 3 3 3 1 RNA binding motif RRM_7 PF16367.3 MSTRG.20035.1_2 - 0.0051 16.8 0.6 51 3.9 0.0 5.0 5 2 0 5 5 5 0 RNA recognition motif SET_assoc PF11767.6 MSTRG.20035.1_2 - 0.012 15.1 1.5 8.6 6.0 0.1 3.9 4 0 0 4 4 4 0 Histone lysine methyltransferase SET associated zf-RING_2 PF13639.4 MSTRG.1924.1_2 - 1e-14 54.4 6.2 1e-14 54.4 6.2 3.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.4 MSTRG.1924.1_2 - 8.9e-11 41.3 6.3 8.9e-11 41.3 6.3 2.8 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 MSTRG.1924.1_2 - 6e-09 35.3 1.7 6e-09 35.3 1.7 2.5 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.5 MSTRG.1924.1_2 - 8e-08 32.3 5.7 8.6e-08 32.2 3.3 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.23 MSTRG.1924.1_2 - 2e-07 30.6 4.2 2e-07 30.6 4.2 2.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 MSTRG.1924.1_2 - 3.2e-07 30.0 3.7 3.2e-07 30.0 3.7 3.0 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 MSTRG.1924.1_2 - 6e-07 29.2 2.9 6e-07 29.2 2.9 2.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 MSTRG.1924.1_2 - 4.3e-06 26.5 1.7 4.3e-06 26.5 1.7 2.2 2 0 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.4 MSTRG.1924.1_2 - 3.9e-05 23.3 2.8 3.9e-05 23.3 2.8 3.1 3 1 1 4 4 4 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.3 MSTRG.1924.1_2 - 0.0047 16.4 3.1 0.02 14.4 3.1 2.1 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.5 MSTRG.1924.1_2 - 0.015 15.2 3.6 0.015 15.2 3.6 2.2 2 1 0 2 2 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.5 MSTRG.1924.1_2 - 0.091 12.8 10.3 0.069 13.1 4.3 3.1 2 1 0 2 2 2 0 RING-variant domain RMF PF04957.10 MSTRG.1924.1_3 - 0.12 12.4 0.9 0.41 10.7 0.9 1.9 1 0 0 1 1 1 0 Ribosome modulation factor Rer1 PF03248.11 MSTRG.18182.2_1 - 1.3e-75 252.7 8.8 2.7e-75 251.7 8.8 1.5 1 0 0 1 1 1 1 Rer1 family DUF2208 PF09973.7 MSTRG.18182.2_1 - 4.8 6.6 8.0 0.077 12.5 0.3 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) Astacin PF01400.22 MSTRG.12779.1_1 - 1.5e-65 220.3 0.0 2.2e-65 219.7 0.0 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) MAM PF00629.21 MSTRG.12779.1_1 - 1.7e-36 125.4 0.0 3e-36 124.6 0.0 1.4 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu EGF PF00008.25 MSTRG.12779.1_1 - 0.0067 16.6 2.5 0.023 14.8 2.5 2.0 1 0 0 1 1 1 1 EGF-like domain EGF_2 PF07974.11 MSTRG.12779.1_1 - 0.16 12.2 8.2 0.55 10.5 8.2 2.0 1 0 0 1 1 1 0 EGF-like domain SipA PF09052.8 MSTRG.6734.1_3 - 5 5.4 4.3 6.9 4.9 4.3 1.1 1 0 0 1 1 1 0 Salmonella invasion protein A WD40 PF00400.30 MSTRG.2572.1_2 - 1.5e-35 120.5 9.9 6.5e-05 23.5 0.0 8.3 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.2572.1_2 - 9.5e-11 41.7 1.3 0.0014 18.8 0.1 5.0 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 MSTRG.2572.1_2 - 2.4e-05 23.3 0.5 0.96 8.2 0.0 4.3 2 1 3 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Hira PF07569.9 MSTRG.2572.1_2 - 0.0018 17.9 0.2 0.081 12.5 0.0 2.7 2 1 1 3 3 3 1 TUP1-like enhancer of split Nup160 PF11715.6 MSTRG.2572.1_2 - 0.0065 15.0 3.3 1.9 6.9 0.1 3.7 2 1 2 4 4 4 2 Nucleoporin Nup120/160 RVT_1 PF00078.25 MSTRG.7092.1_1 - 0.00019 20.9 0.0 0.00022 20.7 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HGWP PF03578.13 MSTRG.18860.1_2 - 0.19 11.3 3.8 0.42 10.2 3.8 1.6 1 0 0 1 1 1 0 HGWP repeat OapA_N PF08525.9 MSTRG.8526.1_1 - 0.57 10.0 3.2 0.35 10.7 0.1 2.3 2 0 0 2 2 2 0 Opacity-associated protein A N-terminal motif SH2 PF00017.22 MSTRG.8526.1_3 - 1.5e-11 44.1 0.1 3.1e-11 43.0 0.1 1.5 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.14 MSTRG.8526.1_3 - 6.7e-11 42.2 3.4 1.4e-10 41.2 1.2 2.6 3 0 0 3 3 3 1 SOCS box Ig_3 PF13927.4 MSTRG.8854.1_1 - 2e-33 114.7 0.4 1.8e-10 41.1 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 MSTRG.8854.1_1 - 1.9e-31 107.8 0.0 1.4e-11 44.2 0.0 3.5 3 1 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.23 MSTRG.8854.1_1 - 5e-29 100.2 0.0 1.5e-09 37.8 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.8854.1_1 - 5.1e-27 93.9 0.1 1.7e-08 34.6 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 MSTRG.8854.1_1 - 7.3e-23 80.7 1.9 4.1e-05 23.6 0.0 6.6 4 3 1 5 5 5 3 Immunoglobulin V-set domain PLAC PF08686.9 MSTRG.8854.1_1 - 9.6e-10 38.9 7.4 9.6e-10 38.9 7.4 2.1 2 0 0 2 2 2 1 PLAC (protease and lacunin) domain Ig_5 PF16681.3 MSTRG.8854.1_1 - 7.3e-07 29.4 0.0 0.18 12.1 0.0 4.0 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 MSTRG.8854.1_1 - 8.4e-05 22.7 0.0 12 6.3 0.0 4.1 4 0 0 4 4 4 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.3 MSTRG.8854.1_1 - 0.0074 16.2 0.0 1.1 9.2 0.0 2.5 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain V-set_CD47 PF08204.9 MSTRG.8854.1_1 - 0.02 14.7 0.0 13 5.7 0.0 3.2 3 0 0 3 3 3 0 CD47 immunoglobulin-like domain MANEC PF07502.12 MSTRG.11697.3_2 - 4.4 7.5 7.1 11 6.2 7.1 1.6 1 1 0 1 1 1 0 MANEC domain Trypsin PF00089.24 MSTRG.17177.1_2 - 4.1e-77 258.8 0.1 4.8e-77 258.6 0.1 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 MSTRG.17177.1_2 - 0.00016 21.9 0.0 0.00053 20.2 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) p450 PF00067.20 MSTRG.27129.1_1 - 3.3e-136 454.6 0.0 3.9e-136 454.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 COPIIcoated_ERV PF07970.10 MSTRG.12979.1_3 - 1.5e-93 312.6 1.4 2.2e-93 312.0 1.4 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.4 MSTRG.12979.1_3 - 2.7e-32 110.8 0.0 1e-31 109.0 0.0 2.1 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) IBN_N PF03810.17 MSTRG.17390.1_2 - 2.9e-18 65.4 0.0 8.9e-17 60.6 0.0 3.0 3 0 0 3 3 3 1 Importin-beta N-terminal domain Cse1 PF08506.8 MSTRG.17390.1_2 - 5.1e-06 25.4 0.8 5.1e-06 25.4 0.8 2.2 2 0 0 2 2 2 1 Cse1 Spore_YhaL PF14147.4 MSTRG.17390.1_2 - 0.003 17.1 0.3 0.61 9.7 0.6 3.5 3 0 0 3 3 3 1 Sporulation protein YhaL Xpo1 PF08389.10 MSTRG.17390.1_2 - 0.0084 16.0 3.5 0.056 13.4 0.2 3.6 4 1 0 4 4 4 1 Exportin 1-like protein RRN3 PF05327.9 MSTRG.17390.1_2 - 0.029 12.8 6.8 2 6.7 5.7 2.7 3 0 0 3 3 3 0 RNA polymerase I specific transcription initiation factor RRN3 DUF3730 PF12530.6 MSTRG.17390.1_2 - 0.042 13.3 0.2 0.1 12.0 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3730) RTP1_C1 PF10363.7 MSTRG.17390.1_2 - 0.056 13.5 0.2 4.4 7.4 0.0 3.8 5 0 0 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF2457 PF10446.7 MSTRG.17390.1_2 - 0.17 10.9 16.1 0.24 10.4 16.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Alpha-L-AF_C PF06964.10 MSTRG.7172.1_2 - 0.024 14.6 0.1 0.036 14.1 0.1 1.1 1 0 0 1 1 1 0 Alpha-L-arabinofuranosidase C-terminal domain Nicastrin PF05450.13 MSTRG.7172.1_3 - 0.082 12.2 0.1 0.12 11.7 0.1 1.2 1 0 0 1 1 1 0 Nicastrin Peptidase_A22B PF04258.11 MSTRG.5516.4_3 - 2.3e-69 233.9 17.9 3.7e-69 233.3 17.9 1.3 1 0 0 1 1 1 1 Signal peptide peptidase PA PF02225.20 MSTRG.5516.4_3 - 2.2e-05 24.3 0.0 4.6e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 PA domain SelP_N PF04592.12 MSTRG.1005.1_1 - 2.1 7.6 13.9 2.8 7.2 13.9 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Na_Pi_cotrans PF02690.13 MSTRG.12408.2_1 - 7.7e-40 136.1 21.7 6e-24 84.6 7.6 2.5 2 0 0 2 2 2 2 Na+/Pi-cotransporter FA_desaturase PF00487.22 MSTRG.12408.2_1 - 1.8 8.2 6.9 5 6.7 6.9 1.8 1 0 0 1 1 1 0 Fatty acid desaturase Mito_carr PF00153.25 MSTRG.18347.1_1 - 4.8e-53 176.9 0.6 6.5e-23 80.3 0.0 3.3 2 1 1 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.25 MSTRG.18347.1_2 - 0.0037 17.0 0.0 0.0069 16.2 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial carrier protein DUF2017 PF09438.8 MSTRG.18347.1_3 - 0.13 11.9 1.0 0.21 11.3 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2017) Glyco_transf_29 PF00777.16 MSTRG.794.1_1 - 7.3e-29 100.8 2.6 1e-28 100.4 2.6 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) SAP30_Sin3_bdg PF13867.4 MSTRG.794.1_3 - 0.078 13.2 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 DUF572 PF04502.11 MSTRG.8979.3_3 - 4.8e-56 190.6 8.7 5.3e-56 190.4 8.7 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) Autophagy_N PF03986.11 MSTRG.8979.3_3 - 0.17 11.7 0.1 0.23 11.2 0.1 1.1 1 0 0 1 1 1 0 Autophagocytosis associated protein (Atg3), N-terminal domain 7tm_1 PF00001.19 MSTRG.16853.1_3 - 7.2e-34 117.1 16.9 1.1e-33 116.5 16.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3 PF11710.6 MSTRG.16853.1_3 - 0.0044 16.7 0.3 0.0044 16.7 0.3 1.6 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 PepSY_TM PF03929.14 MSTRG.16853.1_3 - 0.064 12.5 1.1 0.1 11.9 0.2 1.5 1 1 0 1 1 1 0 PepSY-associated TM region FOP_dimer PF09398.8 MSTRG.19020.2_3 - 8.9e-20 70.6 0.1 1.4e-19 69.9 0.1 1.3 1 0 0 1 1 1 1 FOP N terminal dimerisation domain LisH_2 PF16045.3 MSTRG.19020.2_3 - 2.2e-05 23.2 0.0 5e-05 22.1 0.0 1.7 1 0 0 1 1 1 1 LisH LisH PF08513.9 MSTRG.19020.2_3 - 0.052 13.4 0.4 0.21 11.5 0.2 2.0 2 0 0 2 2 2 0 LisH DUF2423 PF10338.7 MSTRG.19020.2_3 - 0.11 12.6 0.1 0.23 11.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2423) Arm PF00514.21 MSTRG.22609.1_1 - 0.00034 20.4 0.0 0.00063 19.6 0.0 1.4 1 0 0 1 1 1 1 Armadillo/beta-catenin-like repeat zf-C2H2 PF00096.24 MSTRG.17969.1_2 - 3.7e-18 64.8 42.7 2e-05 24.7 1.0 8.0 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.17969.1_2 - 8.5e-12 44.7 55.7 0.0013 19.3 0.9 8.7 8 0 0 8 8 8 5 C2H2-type zinc finger zf-H2C2_2 PF13465.4 MSTRG.17969.1_2 - 1.3e-09 38.0 41.5 4e-06 26.9 0.7 8.5 9 0 0 9 9 9 3 Zinc-finger double domain zf-H2C2_5 PF13909.4 MSTRG.17969.1_2 - 0.00024 20.7 1.9 0.00024 20.7 1.9 5.5 6 0 0 6 6 6 1 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.4 MSTRG.17969.1_2 - 0.0091 15.8 0.9 0.0091 15.8 0.9 7.0 7 0 0 7 7 7 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.17969.1_2 - 0.014 15.5 0.6 0.014 15.5 0.6 5.9 7 0 0 7 7 7 0 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.3 MSTRG.17969.1_2 - 1.6 9.3 12.0 17 6.0 0.5 4.6 3 1 1 4 4 4 0 FOXP coiled-coil domain APP_E2 PF12925.5 MSTRG.16217.1_1 - 7.8e-73 244.1 9.9 1.4e-72 243.3 9.9 1.4 1 0 0 1 1 1 1 E2 domain of amyloid precursor protein APP_N PF02177.14 MSTRG.16217.1_1 - 3.8e-43 145.8 0.6 3.8e-43 145.8 0.6 1.9 2 0 0 2 2 2 1 Amyloid A4 N-terminal heparin-binding Beta-APP PF03494.11 MSTRG.16217.1_1 - 5.6e-27 93.2 1.3 9.3e-27 92.5 1.3 1.4 1 0 0 1 1 1 1 Beta-amyloid peptide (beta-APP) APP_amyloid PF10515.7 MSTRG.16217.1_1 - 1.6e-25 89.3 0.2 5.6e-25 87.5 0.2 2.0 1 0 0 1 1 1 1 beta-amyloid precursor protein C-terminus APP_Cu_bd PF12924.5 MSTRG.16217.1_1 - 7.5e-24 84.1 5.4 2e-22 79.6 3.0 2.7 2 0 0 2 2 2 1 Copper-binding of amyloid precursor, CuBD HrpE PF06188.10 MSTRG.16217.1_1 - 0.32 10.7 6.4 0.62 9.8 6.4 1.4 1 0 0 1 1 1 0 HrpE/YscL/FliH and V-type ATPase subunit E PI3K_1B_p101 PF10486.7 MSTRG.16217.1_1 - 1.5 6.4 13.5 2.2 5.8 13.5 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Activator-TraM PF11657.6 MSTRG.16217.1_1 - 3.1 7.5 6.2 6 6.6 6.2 1.4 1 0 0 1 1 1 0 Transcriptional activator TraM PilJ PF13675.4 MSTRG.16217.1_1 - 5.8 6.9 6.4 2.2 8.2 0.7 2.7 1 1 2 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Dynamin_M PF01031.18 MSTRG.23790.1_2 - 5.2e-95 317.8 0.8 7.1e-95 317.4 0.8 1.2 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.21 MSTRG.23790.1_2 - 5.1e-55 186.0 0.0 7.6e-55 185.4 0.0 1.3 1 0 0 1 1 1 1 Dynamin family PH PF00169.27 MSTRG.23790.1_2 - 5.2e-05 23.6 0.1 9.7e-05 22.7 0.1 1.4 1 0 0 1 1 1 1 PH domain MMR_HSR1 PF01926.21 MSTRG.23790.1_2 - 0.0027 17.6 0.0 0.0057 16.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Spermine_synth PF01564.15 MSTRG.23790.1_2 - 0.11 11.3 0.0 0.2 10.5 0.0 1.3 1 0 0 1 1 1 0 Spermine/spermidine synthase zf-C3HC4 PF00097.23 MSTRG.12004.3_1 - 2.9e-06 26.9 10.1 5e-06 26.1 10.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 MSTRG.12004.3_1 - 8e-06 25.8 7.9 2.1e-05 24.4 7.9 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 MSTRG.12004.3_1 - 9e-06 25.3 9.8 1.4e-05 24.7 9.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 MSTRG.12004.3_1 - 3.3e-05 23.5 10.3 6.8e-05 22.5 10.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.12004.3_1 - 6e-05 23.1 9.7 0.00012 22.1 9.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.4 MSTRG.12004.3_1 - 0.00012 21.8 12.1 0.00021 21.1 12.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_6 PF14835.4 MSTRG.12004.3_1 - 0.00028 20.6 1.3 0.00028 20.6 1.3 1.6 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.4 MSTRG.12004.3_1 - 0.001 18.9 6.7 0.0027 17.6 6.6 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_4 PF14570.4 MSTRG.12004.3_1 - 0.0027 17.2 9.0 0.0084 15.7 8.8 1.8 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.3 MSTRG.12004.3_1 - 0.0044 17.0 7.3 0.0044 17.0 7.3 1.6 2 0 0 2 2 2 1 zinc RING finger of MSL2 zf-C3HC4_5 PF17121.3 MSTRG.12004.3_1 - 0.023 14.5 9.3 0.038 13.7 5.3 2.4 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) NinF PF05810.10 MSTRG.12004.3_1 - 0.026 14.3 1.0 0.026 14.3 1.0 2.2 2 1 0 2 2 2 0 NinF protein Prok-RING_4 PF14447.4 MSTRG.12004.3_1 - 0.031 14.0 9.1 0.052 13.3 9.1 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.5 MSTRG.12004.3_1 - 0.11 12.6 6.2 0.25 11.5 6.2 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain RRM_1 PF00076.20 MSTRG.24380.1_3 - 5.8e-62 205.3 0.1 1e-19 69.9 0.0 3.6 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 MSTRG.24380.1_3 - 3.5e-16 58.8 0.0 9.4e-06 25.1 0.0 3.2 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 MSTRG.24380.1_3 - 4.1e-05 23.2 0.0 0.23 11.2 0.0 3.4 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_3 PF08777.9 MSTRG.24380.1_3 - 0.0026 17.6 0.0 0.77 9.7 0.0 2.7 2 0 0 2 2 2 1 RNA binding motif Nup35_RRM PF05172.11 MSTRG.24380.1_3 - 0.0052 16.6 0.1 3 7.7 0.0 3.3 2 1 1 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.3 MSTRG.24380.1_3 - 0.041 13.9 0.0 1.5 8.9 0.0 2.9 3 0 0 3 3 3 0 RNA recognition motif YqeY PF09424.8 MSTRG.24380.1_3 - 0.14 12.0 0.1 0.25 11.3 0.1 1.3 1 0 0 1 1 1 0 Yqey-like protein UPF0139 PF03669.11 MSTRG.27446.1_1 - 6e-49 163.7 1.1 1.1e-48 162.9 1.1 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) DUF626 PF04776.10 MSTRG.27446.1_1 - 0.093 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF626) DUF4528 PF15031.4 MSTRG.19202.1_1 - 0.07 13.1 0.5 0.094 12.6 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4528) BHD_1 PF10403.7 MSTRG.19202.1_2 - 0.0082 15.8 0.1 0.39 10.5 0.1 2.5 1 1 1 2 2 2 2 Rad4 beta-hairpin domain 1 F-box_4 PF15966.3 MSTRG.19202.1_2 - 0.078 12.7 3.2 0.65 9.8 0.4 2.1 1 1 1 2 2 2 0 F-box Sec10 PF07393.9 MSTRG.4693.1_3 - 8e-161 536.8 23.1 2.6e-159 531.8 15.5 3.3 2 1 0 2 2 2 1 Exocyst complex component Sec10 Jnk-SapK_ap_N PF09744.7 MSTRG.4693.1_3 - 0.0016 18.5 4.5 0.0016 18.5 4.5 2.1 2 0 0 2 2 2 1 JNK_SAPK-associated protein-1 Phage_GP20 PF06810.9 MSTRG.4693.1_3 - 0.18 11.5 1.9 0.42 10.3 1.9 1.5 1 0 0 1 1 1 0 Phage minor structural protein GP20 TMPIT PF07851.11 MSTRG.4693.1_3 - 0.2 10.7 5.9 2.4 7.2 0.2 2.4 2 0 0 2 2 2 0 TMPIT-like protein V_ATPase_I PF01496.17 MSTRG.4693.1_3 - 0.31 8.8 7.8 0.044 11.6 3.8 1.6 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family ING PF12998.5 MSTRG.4693.1_3 - 0.33 11.4 4.9 0.38 11.2 2.2 2.5 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding OmpH PF03938.12 MSTRG.4693.1_3 - 0.4 10.6 6.4 0.057 13.3 1.9 1.8 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) MbeD_MobD PF04899.10 MSTRG.4693.1_3 - 1.5 8.8 4.5 26 4.9 0.0 3.4 3 0 0 3 3 3 0 MbeD/MobD like KxDL PF10241.7 MSTRG.4693.1_3 - 4.4 7.5 7.4 2.1 8.5 3.7 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein DUF724 PF05266.12 MSTRG.4693.1_3 - 6.3 6.4 9.8 0.42 10.3 3.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) TelA PF05816.9 MSTRG.4693.1_3 - 7.9 5.3 11.8 0.031 13.2 0.4 2.6 4 0 0 4 4 4 0 Toxic anion resistance protein (TelA) ABC_membrane PF00664.21 MSTRG.18609.1_1 - 4.5e-128 426.5 25.3 1.6e-66 224.6 8.4 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 MSTRG.18609.1_1 - 9.2e-71 236.6 0.0 4.5e-34 117.8 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 MSTRG.18609.1_1 - 7.1e-13 48.4 0.0 6.8e-06 25.5 0.0 3.4 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 MSTRG.18609.1_1 - 3.2e-09 37.3 0.0 0.0025 18.1 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain DUF258 PF03193.14 MSTRG.18609.1_1 - 2.2e-07 30.8 0.0 0.0096 15.7 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_29 PF13555.4 MSTRG.18609.1_1 - 1.6e-06 27.6 0.5 0.0039 16.7 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.4 MSTRG.18609.1_1 - 1.7e-06 28.2 0.0 0.041 14.0 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_15 PF13175.4 MSTRG.18609.1_1 - 8e-06 25.6 0.0 0.0099 15.4 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.4 MSTRG.18609.1_1 - 0.00042 20.0 0.0 0.32 10.5 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA PF00004.27 MSTRG.18609.1_1 - 0.00048 20.4 3.0 3.2 8.0 0.4 4.7 3 2 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.10 MSTRG.18609.1_1 - 0.0012 18.1 0.1 0.13 11.4 0.0 2.9 3 0 0 3 3 3 1 Zeta toxin G-alpha PF00503.18 MSTRG.18609.1_1 - 0.002 17.2 0.0 0.98 8.4 0.0 2.2 2 0 0 2 2 2 2 G-protein alpha subunit AAA_5 PF07728.12 MSTRG.18609.1_1 - 0.0028 17.5 0.0 3.1 7.7 0.0 3.5 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.4 MSTRG.18609.1_1 - 0.004 17.2 0.0 1.3 9.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.4 MSTRG.18609.1_1 - 0.0076 16.0 0.1 0.081 12.6 0.0 2.6 2 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system RNA_helicase PF00910.20 MSTRG.18609.1_1 - 0.015 15.6 0.0 15 5.9 0.0 3.3 3 0 0 3 3 2 0 RNA helicase DUF87 PF01935.15 MSTRG.18609.1_1 - 0.015 15.2 0.0 3.8 7.3 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function DUF87 Rad17 PF03215.13 MSTRG.18609.1_1 - 0.02 13.7 0.0 1.2 7.8 0.0 2.1 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein ABC_ATPase PF09818.7 MSTRG.18609.1_1 - 0.055 12.1 0.4 4.8 5.7 0.1 2.3 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_28 PF13521.4 MSTRG.18609.1_1 - 0.062 13.4 0.1 14 5.7 0.0 3.1 3 0 0 3 3 3 0 AAA domain APS_kinase PF01583.18 MSTRG.18609.1_1 - 0.069 12.9 0.0 1.3 8.7 0.0 2.4 2 0 0 2 2 2 0 Adenylylsulphate kinase Multi_ubiq PF14452.4 MSTRG.18609.1_1 - 0.08 13.0 0.1 1.9 8.7 0.0 2.9 3 0 0 3 3 3 0 Multiubiquitin AAA_23 PF13476.4 MSTRG.18609.1_1 - 0.089 13.2 0.0 1.2 9.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain Dala_Dala_lig_N PF01820.19 MSTRG.18609.1_1 - 0.13 12.2 0.1 8.4 6.5 0.0 2.6 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus AAA_24 PF13479.4 MSTRG.18609.1_1 - 0.15 11.7 0.0 5.5 6.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.4 MSTRG.18609.1_1 - 0.18 12.0 2.7 2.3 8.4 0.1 3.3 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit RabGAP-TBC PF00566.16 MSTRG.21486.1_2 - 2.8e-54 183.9 2.7 2.8e-54 183.9 2.7 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain bZIP_1 PF00170.19 MSTRG.21486.1_2 - 0.0093 15.9 4.1 0.0093 15.9 4.1 6.1 6 2 0 6 6 6 2 bZIP transcription factor PspB PF06667.10 MSTRG.21486.1_2 - 3.9 7.4 14.6 2.8 7.9 1.2 4.0 3 0 0 3 3 3 0 Phage shock protein B zf-C3HC4_2 PF13923.4 MSTRG.14396.1_3 - 1e-08 34.7 9.3 2.3e-08 33.6 9.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.14396.1_3 - 1.2e-08 35.0 9.9 2.4e-08 34.0 9.9 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.23 MSTRG.14396.1_3 - 5.6e-08 32.4 10.1 1.1e-07 31.4 10.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 MSTRG.14396.1_3 - 1.7e-07 30.9 6.6 3.3e-07 29.9 6.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.14396.1_3 - 2e-07 30.8 7.6 5.1e-07 29.5 7.6 1.7 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.4 MSTRG.14396.1_3 - 2.9e-05 23.7 11.4 0.00046 19.9 11.0 2.2 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 MSTRG.14396.1_3 - 8.6e-05 22.3 11.9 0.00024 20.9 10.1 2.1 1 1 1 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.5 MSTRG.14396.1_3 - 0.00014 21.9 9.7 0.0003 20.9 9.7 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.4 MSTRG.14396.1_3 - 0.00029 20.8 11.1 0.00061 19.8 11.1 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.5 MSTRG.14396.1_3 - 0.0037 17.1 5.5 0.0073 16.2 5.5 1.5 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.4 MSTRG.14396.1_3 - 0.0056 16.4 5.0 0.17 11.7 7.0 2.1 1 1 1 2 2 2 1 zf-RING of BARD1-type protein Zn_ribbon_17 PF17120.3 MSTRG.14396.1_3 - 0.17 11.4 7.3 0.21 11.1 6.3 1.7 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C2H2_4 PF13894.4 MSTRG.14396.1_3 - 0.3 11.9 6.1 1.1 10.2 0.1 3.4 1 1 2 3 3 3 0 C2H2-type zinc finger zf-RING_10 PF16685.3 MSTRG.14396.1_3 - 0.6 10.1 7.0 0.6 10.1 5.3 1.8 1 1 1 2 2 2 0 zinc RING finger of MSL2 Rad50_zn_hook PF04423.12 MSTRG.14396.1_3 - 0.65 9.7 3.9 13 5.5 0.1 2.3 2 0 0 2 2 2 0 Rad50 zinc hook motif GAGA PF09237.9 MSTRG.14396.1_3 - 1.4 8.7 4.7 5.4 6.8 1.2 2.5 2 1 0 2 2 2 0 GAGA factor zf-P11 PF03854.12 MSTRG.14396.1_3 - 2.1 8.0 8.8 6 6.5 5.9 2.2 1 1 1 2 2 2 0 P-11 zinc finger zf-C3HC4_5 PF17121.3 MSTRG.14396.1_3 - 3 7.7 8.1 28 4.6 8.1 2.4 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.4 MSTRG.14396.1_3 - 4.3 7.0 11.0 13 5.5 0.5 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain VWC PF00093.16 MSTRG.7564.2_3 - 3.5e-24 84.7 96.0 2e-09 37.5 16.1 12.8 8 2 4 12 12 12 5 von Willebrand factor type C domain Antistasin PF02822.12 MSTRG.7564.2_3 - 6e-15 55.4 64.5 1.2e-06 28.9 9.4 12.9 14 0 0 14 14 14 4 Antistasin family IGFBP PF00219.16 MSTRG.7564.2_3 - 1.7e-06 28.4 19.7 1.7e-06 28.4 19.7 14.1 10 4 3 13 13 13 1 Insulin-like growth factor binding protein TILa PF12714.5 MSTRG.7564.2_3 - 0.00022 21.0 8.1 0.00022 21.0 8.1 11.6 12 1 0 12 12 12 3 TILa domain DUF4064 PF13273.4 MSTRG.7564.2_3 - 0.14 12.4 0.1 0.14 12.4 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) HEAT PF02985.20 MSTRG.11399.1_3 - 0.0049 16.9 1.2 18 5.8 0.0 5.6 6 0 0 6 6 6 1 HEAT repeat HEAT_EZ PF13513.4 MSTRG.11399.1_3 - 0.12 12.7 0.8 7.5 7.0 0.1 4.1 4 0 0 4 4 4 0 HEAT-like repeat AT_hook PF02178.17 MSTRG.11399.1_3 - 0.18 11.6 2.6 0.53 10.2 2.6 1.8 1 0 0 1 1 1 0 AT hook motif DUF3385 PF11865.6 MSTRG.11399.1_3 - 0.2 11.3 2.8 5.6 6.7 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3385) Cnd1 PF12717.5 MSTRG.11399.1_3 - 0.42 10.5 17.4 0.97 9.3 0.1 5.6 6 2 2 8 8 8 0 non-SMC mitotic condensation complex subunit 1 FANCI_S2 PF14676.4 MSTRG.11399.1_3 - 0.57 10.3 3.6 13 5.9 0.5 3.4 2 1 0 2 2 2 0 FANCI solenoid 2 PLU-1 PF08429.9 MSTRG.4403.2_2 - 2e-81 273.6 16.6 5.7e-79 265.6 8.1 2.5 3 0 0 3 3 3 2 PLU-1-like protein JmjC PF02373.20 MSTRG.4403.2_2 - 6.5e-43 145.7 0.2 4e-42 143.1 0.5 2.1 2 0 0 2 2 2 1 JmjC domain, hydroxylase JmjN PF02375.15 MSTRG.4403.2_2 - 5.5e-17 61.3 1.0 1.2e-16 60.2 1.0 1.7 1 0 0 1 1 1 1 jmjN domain zf-C5HC2 PF02928.14 MSTRG.4403.2_2 - 5.7e-16 58.5 12.9 5.7e-16 58.5 12.9 4.0 4 0 0 4 4 4 1 C5HC2 zinc finger ARID PF01388.19 MSTRG.4403.2_2 - 9.3e-16 58.1 0.0 2.1e-15 57.0 0.0 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain PHD PF00628.27 MSTRG.4403.2_2 - 1.2e-12 47.3 4.3 1.2e-12 47.3 4.3 3.7 3 0 0 3 3 3 2 PHD-finger DDE_Tnp_IS66 PF03050.12 MSTRG.4403.2_2 - 0.054 12.8 0.0 0.14 11.4 0.0 1.6 1 0 0 1 1 1 0 Transposase IS66 family Zf_RING PF16744.3 MSTRG.4403.2_2 - 0.22 11.5 6.5 5.5 7.1 0.4 3.2 2 0 0 2 2 2 0 KIAA1045 RING finger Sec7 PF01369.18 MSTRG.10971.1_1 - 3.8e-68 228.7 0.1 6.4e-68 228.0 0.1 1.3 1 0 0 1 1 1 1 Sec7 domain PH PF00169.27 MSTRG.10971.1_1 - 1.4e-27 96.1 0.1 2.5e-27 95.3 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 MSTRG.10971.1_1 - 8.8e-05 22.8 0.0 0.00017 21.9 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.4 MSTRG.10971.1_1 - 0.011 15.9 0.0 0.03 14.5 0.0 1.7 2 0 0 2 2 2 0 Pleckstrin homology domain PH_3 PF14593.4 MSTRG.10971.1_1 - 0.025 14.6 0.0 0.054 13.5 0.0 1.6 1 0 0 1 1 1 0 PH domain DUF342 PF03961.11 MSTRG.10971.1_1 - 0.039 12.4 0.4 0.053 12.0 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) GPS2_interact PF15784.3 MSTRG.10971.1_1 - 0.047 14.2 1.6 0.092 13.3 1.6 1.4 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain Gelsolin PF00626.20 MSTRG.25365.4_2 - 2.9e-21 75.0 0.1 1.9e-05 24.3 0.0 5.8 5 0 0 5 5 5 5 Gelsolin repeat VHP PF02209.17 MSTRG.25365.4_2 - 6.5e-16 58.0 0.3 2e-15 56.4 0.3 1.9 1 0 0 1 1 1 1 Villin headpiece domain SSDP PF04503.11 MSTRG.8970.1_1 - 7.8e-90 301.9 81.1 7.8e-90 301.9 81.1 2.0 2 0 0 2 2 2 1 Single-stranded DNA binding protein, SSDP Integrin_beta PF00362.16 MSTRG.11608.1_3 - 5.3e-107 357.0 0.0 7.4e-107 356.5 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_B_tail PF07965.10 MSTRG.11608.1_3 - 2e-20 72.9 3.5 2e-20 72.9 3.5 4.2 2 1 1 4 4 4 1 Integrin beta tail domain Integrin_b_cyt PF08725.9 MSTRG.11608.1_3 - 5.2e-14 51.5 0.0 1.1e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain PSI_integrin PF17205.1 MSTRG.11608.1_3 - 1.7e-13 50.1 7.2 1.7e-13 50.1 7.2 4.1 3 1 0 3 3 3 1 Integrin plexin domain EGF_2 PF07974.11 MSTRG.11608.1_3 - 1.1e-06 28.7 92.2 0.0014 18.8 16.7 6.1 4 1 1 5 5 5 4 EGF-like domain Ank_2 PF12796.5 MSTRG.11590.1_2 - 4.1e-131 427.7 34.3 1.4e-18 67.1 0.6 12.0 2 2 9 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.11590.1_2 - 3e-113 368.7 40.9 3.9e-12 46.3 0.1 18.0 10 4 11 21 21 21 20 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.11590.1_2 - 8.8e-108 348.3 68.2 3.5e-06 27.1 0.0 23.3 21 2 2 23 23 23 22 Ankyrin repeat Ank_5 PF13857.4 MSTRG.11590.1_2 - 3.6e-96 313.4 52.7 1.9e-08 34.3 0.1 18.3 4 4 15 19 19 19 18 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.11590.1_2 - 4.2e-92 290.8 37.3 5e-05 23.3 0.0 22.5 22 0 0 22 22 22 20 Ankyrin repeat RhoGEF PF00621.18 MSTRG.14992.1_2 - 1.4e-40 139.3 0.1 2.9e-40 138.3 0.1 1.5 1 0 0 1 1 1 1 RhoGEF domain PTCB-BRCT PF12738.5 MSTRG.14992.1_2 - 1.4e-25 88.9 0.9 3e-17 62.2 0.1 2.6 2 0 0 2 2 2 2 twin BRCT domain BRCT PF00533.24 MSTRG.14992.1_2 - 2.5e-19 69.3 2.1 2e-08 34.4 0.1 3.0 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.3 MSTRG.14992.1_2 - 2.7e-05 24.3 0.1 0.063 13.6 0.0 2.9 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.3 MSTRG.14992.1_2 - 0.00013 22.0 0.3 0.048 13.8 0.0 2.7 2 0 0 2 2 2 2 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.3 MSTRG.14992.1_2 - 0.031 14.0 0.0 0.12 12.2 0.0 2.0 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain HEAT PF02985.20 MSTRG.18956.1_3 - 4.4e-29 97.8 8.9 0.001 19.0 0.1 11.7 11 0 0 11 11 11 6 HEAT repeat HEAT_EZ PF13513.4 MSTRG.18956.1_3 - 6.6e-29 99.8 6.8 4.9e-12 45.9 0.0 10.4 9 1 1 10 10 10 5 HEAT-like repeat HEAT_2 PF13646.4 MSTRG.18956.1_3 - 2e-17 63.2 0.0 0.00013 22.1 0.0 6.9 5 2 2 7 7 7 5 HEAT repeats IBN_N PF03810.17 MSTRG.18956.1_3 - 1.3e-16 60.1 0.4 1.6e-15 56.6 0.0 2.9 2 0 0 2 2 2 1 Importin-beta N-terminal domain Cnd1 PF12717.5 MSTRG.18956.1_3 - 2.8e-13 50.1 0.0 0.024 14.5 0.1 4.5 3 1 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 Arm PF00514.21 MSTRG.18956.1_3 - 5.9e-13 48.2 10.2 0.016 15.1 0.1 7.4 7 0 0 7 7 7 3 Armadillo/beta-catenin-like repeat Vac14_Fab1_bd PF12755.5 MSTRG.18956.1_3 - 1.2e-12 48.1 0.0 0.00025 21.4 0.1 5.2 4 1 1 5 5 5 2 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.18 MSTRG.18956.1_3 - 2.7e-08 32.7 0.6 0.017 13.6 0.1 4.8 3 2 0 3 3 3 3 Adaptin N terminal region UNC45-central PF11701.6 MSTRG.18956.1_3 - 2.3e-05 24.2 0.4 0.0047 16.7 0.1 3.5 4 0 0 4 4 4 1 Myosin-binding striated muscle assembly central Dopey_N PF04118.12 MSTRG.18956.1_3 - 7.3e-05 22.0 0.2 0.00023 20.3 0.1 1.9 2 0 0 2 2 2 1 Dopey, N-terminal DUF3385 PF11865.6 MSTRG.18956.1_3 - 0.025 14.3 1.5 3 7.6 0.0 4.4 5 1 1 6 6 6 0 Domain of unknown function (DUF3385) DUF3437 PF11919.6 MSTRG.18956.1_3 - 0.062 13.1 0.0 3.8 7.4 0.0 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3437) Caerin_1 PF07440.10 MSTRG.18956.1_3 - 0.14 12.1 0.2 0.88 9.6 0.0 2.4 2 0 0 2 2 2 0 Caerin 1 protein MMS19_C PF12460.6 MSTRG.18956.1_3 - 0.4 9.6 5.1 0.91 8.4 0.1 3.5 4 1 1 5 5 5 0 RNAPII transcription regulator C-terminal ZZ PF00569.15 MSTRG.2049.4_2 - 4e-18 64.8 4.7 1.1e-17 63.4 4.7 1.8 1 0 0 1 1 1 1 Zinc finger, ZZ type EF-hand_3 PF09069.9 MSTRG.2049.4_2 - 2e-12 47.2 0.5 3.7e-12 46.4 0.5 1.5 1 0 0 1 1 1 1 EF-hand NMDAR2_C PF10565.7 MSTRG.27924.1_3 - 2.3e-42 145.6 0.0 2.7e-42 145.4 0.0 1.1 1 0 0 1 1 1 1 N-methyl D-aspartate receptor 2B3 C-terminus ubiquitin PF00240.21 MSTRG.29486.1_3 - 1.8e-16 59.5 0.0 2.3e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 MSTRG.29486.1_3 - 2.5e-05 23.9 0.0 3.2e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 MSTRG.29486.1_3 - 0.007 16.8 0.0 0.0081 16.6 0.0 1.2 1 1 0 1 1 1 1 DUF2407 ubiquitin-like domain UL11 PF11094.6 MSTRG.9844.1_3 - 0.022 14.5 0.3 0.048 13.4 0.3 1.5 1 0 0 1 1 1 0 Membrane-associated tegument protein YoaP PF14268.4 MSTRG.9844.1_3 - 0.045 13.1 0.0 0.089 12.2 0.0 1.4 1 0 0 1 1 1 0 YoaP-like PGM_PMM_I PF02878.14 MSTRG.10732.1_1 - 4.2e-38 130.1 0.1 7.5e-38 129.2 0.1 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.14 MSTRG.10732.1_1 - 2.2e-31 108.2 0.0 4.5e-31 107.3 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.14 MSTRG.10732.1_1 - 2.4e-14 53.7 0.1 6.2e-14 52.3 0.1 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.18 MSTRG.10732.1_1 - 7e-06 26.0 0.0 1.7e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Cadherin PF00028.15 MSTRG.28251.1_2 - 4.8e-05 23.6 0.0 8.8e-05 22.7 0.0 1.4 2 0 0 2 2 2 1 Cadherin domain DUF1966 PF09260.9 MSTRG.28251.1_2 - 0.14 12.3 0.0 0.19 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1966) Alpha_kinase PF02816.16 MSTRG.2867.1_3 - 2e-28 99.8 0.0 2.4e-28 99.5 0.0 1.1 1 0 0 1 1 1 1 Alpha-kinase family Histone_H2A_C PF16211.3 MSTRG.24593.1_1 - 0.0011 18.5 0.1 0.0027 17.3 0.1 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A LRR_4 PF12799.5 MSTRG.24593.1_2 - 1.2e-07 31.7 11.2 0.69 10.3 0.4 6.8 3 1 3 7 7 7 3 Leucine Rich repeats (2 copies) F-box PF00646.31 MSTRG.24593.1_2 - 4.1e-07 29.6 0.4 4.1e-07 29.6 0.4 2.6 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.5 MSTRG.24593.1_2 - 1e-06 28.4 2.2 3.8e-06 26.5 2.2 2.1 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.3 MSTRG.24593.1_2 - 0.0096 15.7 0.2 0.0096 15.7 0.2 2.1 2 0 0 2 2 2 1 F-box LRR_6 PF13516.4 MSTRG.24593.1_2 - 0.084 12.8 13.1 89 3.4 0.0 7.8 9 0 0 9 9 9 0 Leucine Rich repeat Adeno_E3_CR2 PF02439.13 MSTRG.24593.1_2 - 0.09 12.4 0.2 0.19 11.4 0.2 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 LRR_2 PF07723.11 MSTRG.24593.1_2 - 8.1 7.2 9.6 58 4.5 0.3 4.9 5 0 0 5 5 5 0 Leucine Rich Repeat Biliv-reduc_cat PF09166.8 MSTRG.7058.1_2 - 2.1e-49 166.4 0.0 2.8e-49 166.0 0.0 1.2 1 0 0 1 1 1 1 Biliverdin reductase, catalytic GFO_IDH_MocA PF01408.20 MSTRG.7058.1_2 - 3.5e-06 27.7 0.0 5.6e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold EGF_CA PF07645.13 MSTRG.26223.2_3 - 1.1e-29 102.2 61.8 1.5e-08 34.6 7.9 5.7 6 0 0 6 6 6 4 Calcium-binding EGF domain cEGF PF12662.5 MSTRG.26223.2_3 - 1.1e-21 76.3 22.6 5.8e-08 32.4 0.2 5.5 5 0 0 5 5 5 4 Complement Clr-like EGF-like FXa_inhibition PF14670.4 MSTRG.26223.2_3 - 1.3e-06 28.5 24.4 2.5e-05 24.3 4.8 5.6 5 1 0 5 5 5 2 Coagulation Factor Xa inhibitory site Tme5_EGF_like PF09064.8 MSTRG.26223.2_3 - 0.0055 16.4 5.8 0.0055 16.4 5.8 3.6 5 0 0 5 5 5 1 Thrombomodulin like fifth domain, EGF-like EGF_3 PF12947.5 MSTRG.26223.2_3 - 0.0082 16.2 1.0 0.0082 16.2 1.0 6.6 6 2 0 6 6 6 3 EGF domain EGF PF00008.25 MSTRG.26223.2_3 - 0.0084 16.3 9.0 0.0084 16.3 9.0 5.7 6 0 0 6 6 6 3 EGF-like domain hEGF PF12661.5 MSTRG.26223.2_3 - 0.024 15.2 2.9 0.024 15.2 2.9 6.1 5 1 0 6 6 6 0 Human growth factor-like EGF GP38 PF05268.9 MSTRG.26454.1_1 - 0.036 13.6 1.0 0.048 13.2 1.0 1.1 1 0 0 1 1 1 0 Phage tail fibre adhesin Gp38 RhoGEF PF00621.18 MSTRG.15449.1_3 - 5.2e-40 137.5 2.1 1.1e-39 136.4 2.1 1.6 1 0 0 1 1 1 1 RhoGEF domain BAR PF03114.16 MSTRG.15449.1_3 - 3.4e-39 134.8 7.2 3.5e-39 134.7 2.9 2.8 3 0 0 3 3 3 1 BAR domain SH3_9 PF14604.4 MSTRG.15449.1_3 - 4.9e-11 42.2 0.0 4e-10 39.3 0.0 2.3 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.15449.1_3 - 2e-10 40.1 0.0 6.8e-06 25.5 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.26 MSTRG.15449.1_3 - 1.2e-08 34.3 0.0 1e-06 28.1 0.0 2.7 2 0 0 2 2 2 1 SH3 domain Guanylate_cyc PF00211.18 MSTRG.18900.1_1 - 3.2e-114 378.8 0.1 1.5e-58 197.3 0.0 2.2 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain AC_N PF16214.3 MSTRG.18900.1_1 - 0.33 9.9 0.0 0.33 9.9 0.0 3.4 4 0 0 4 4 4 0 Adenylyl cyclase N-terminal extracellular and transmembrane region Pkinase_Tyr PF07714.15 MSTRG.7414.2_2 - 3.7e-89 298.3 0.0 4.6e-89 298.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.7414.2_2 - 8e-36 123.6 0.0 2.8e-29 102.2 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain zf-LITAF-like PF10601.7 MSTRG.18646.2_1 - 2.3e-25 88.5 16.8 6e-25 87.2 16.8 1.7 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain Sulfatase PF00884.21 MSTRG.28922.1_3 - 1.4e-36 126.3 0.0 1.7e-36 126.1 0.0 1.0 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.20 MSTRG.28922.1_3 - 0.001 18.6 0.1 0.0014 18.1 0.1 1.3 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Phage_B PF02304.13 MSTRG.27022.2_1 - 0.056 13.7 0.2 3.3 8.0 0.0 2.6 2 0 0 2 2 2 0 Scaffold protein B RRM_1 PF00076.20 MSTRG.27022.2_2 - 0.025 14.3 0.0 0.06 13.1 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1436 PF07262.9 MSTRG.27022.2_2 - 0.057 13.0 0.1 0.14 11.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1436) MAPEG PF01124.16 MSTRG.8071.1_3 - 9.2e-19 67.5 1.6 1.2e-18 67.2 1.6 1.1 1 0 0 1 1 1 1 MAPEG family RRM_1 PF00076.20 MSTRG.23211.1_2 - 2e-28 97.9 0.0 2.8e-10 39.7 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 MSTRG.23211.1_2 - 0.011 15.7 0.0 2.3 8.2 0.0 2.7 3 0 0 3 3 3 0 RNA binding motif zf-Tim10_DDP PF02953.13 MSTRG.1312.1_1 - 3.2e-16 58.6 4.4 5.9e-16 57.7 4.4 1.4 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF2116 PF09889.7 MSTRG.1312.1_1 - 0.099 12.5 1.1 0.24 11.3 1.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) CD36 PF01130.19 MSTRG.19621.1_1 - 1.4e-155 518.2 1.0 1.7e-155 517.9 1.0 1.1 1 0 0 1 1 1 1 CD36 family DUF2929 PF11151.6 MSTRG.19621.1_1 - 0.14 12.3 2.4 0.92 9.7 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2929) DUF3068 PF11271.6 MSTRG.19621.1_1 - 0.18 10.9 2.0 0.53 9.4 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3068) DUF3496 PF12001.6 MSTRG.10689.2_1 - 0.057 13.7 13.0 16 5.8 0.1 5.4 6 0 0 6 6 6 0 Domain of unknown function (DUF3496) VWA_N PF08399.9 MSTRG.10689.2_2 - 0.00048 20.5 1.5 52 4.2 0.0 4.4 4 0 0 4 4 4 4 VWA N-terminal Somatomedin_B PF01033.15 MSTRG.10689.2_3 - 7.8e-19 67.7 43.7 1e-10 41.6 16.8 2.9 2 0 0 2 2 2 2 Somatomedin B domain Hemopexin PF00045.17 MSTRG.10689.2_3 - 3.5e-15 55.5 3.3 1.5e-12 47.1 0.1 4.7 4 0 0 4 4 4 1 Hemopexin PTCB-BRCT PF12738.5 MSTRG.15700.2_1 - 4.8e-48 160.8 2.0 1.3e-19 69.8 0.0 5.0 5 0 0 5 5 5 4 twin BRCT domain BRCT PF00533.24 MSTRG.15700.2_1 - 3.2e-40 136.3 0.0 9.5e-11 41.8 0.0 6.3 6 1 0 6 6 6 5 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.3 MSTRG.15700.2_1 - 2.9e-29 101.2 0.0 8.1e-05 22.8 0.0 6.0 5 0 0 5 5 5 5 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.3 MSTRG.15700.2_1 - 1.5e-23 82.4 0.0 4.9e-17 61.5 0.0 3.9 3 0 0 3 3 3 2 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.3 MSTRG.15700.2_1 - 5.3e-17 61.7 0.1 5.4e-06 26.5 0.0 5.4 5 0 0 5 5 5 4 DNA ligase 3 BRCT domain Serinc PF03348.13 MSTRG.5915.1_1 - 9.9e-12 44.4 11.4 1.3e-11 44.0 11.4 1.1 1 0 0 1 1 1 1 Serine incorporator (Serinc) Clc-like PF07062.10 MSTRG.5915.1_1 - 0.029 13.7 2.3 0.037 13.4 2.3 1.2 1 1 0 1 1 1 0 Clc-like fn3 PF00041.19 MSTRG.4733.1_1 - 3.5e-16 59.2 0.2 3.5e-16 59.2 0.2 1.5 2 0 0 2 2 2 1 Fibronectin type III domain I-set PF07679.14 MSTRG.4733.1_1 - 1.3e-07 31.5 0.0 3.2e-07 30.2 0.0 1.6 2 0 0 2 2 2 1 Immunoglobulin I-set domain V-set PF07686.15 MSTRG.4733.1_1 - 5.1e-06 26.5 0.0 1.2e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 MSTRG.4733.1_1 - 1.2e-05 25.2 0.0 2.6e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.4733.1_1 - 4.1e-05 24.0 0.2 0.00016 22.1 0.0 2.0 2 1 0 2 2 2 1 Immunoglobulin domain Pur_ac_phosph_N PF16656.3 MSTRG.4733.1_1 - 0.0023 18.3 0.2 0.0067 16.8 0.2 1.8 1 1 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Herpes_gE PF02480.14 MSTRG.4733.1_1 - 0.0031 16.2 0.0 0.0035 16.0 0.0 1.1 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E Ig_2 PF13895.4 MSTRG.4733.1_1 - 0.015 15.5 0.0 0.029 14.6 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain UNC-93 PF05978.14 MSTRG.4733.1_1 - 0.043 13.4 0.0 0.058 13.0 0.0 1.2 1 0 0 1 1 1 0 Ion channel regulatory protein UNC-93 Metallophos PF00149.26 MSTRG.15670.1_1 - 1.1e-11 45.5 0.1 1.8e-11 44.8 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TPT PF03151.14 MSTRG.23819.1_2 - 2.2e-16 59.9 18.1 3.1e-16 59.5 18.1 1.2 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.18 MSTRG.23819.1_2 - 0.0074 16.3 25.7 0.04 13.9 8.7 2.4 2 0 0 2 2 2 2 EamA-like transporter family DUF2627 PF11118.6 MSTRG.23819.1_2 - 0.62 10.5 7.4 1.2 9.7 4.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2627) DUF3689 PF12463.6 MSTRG.13110.1_1 - 3.8e-129 430.2 12.3 7.2e-129 429.3 12.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3689) Translin PF01997.14 MSTRG.13110.1_1 - 0.06 13.2 0.1 0.13 12.1 0.1 1.5 1 0 0 1 1 1 0 Translin family WD40 PF00400.30 MSTRG.8640.2_3 - 2.7e-15 56.3 14.5 0.0036 18.0 0.0 7.2 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.8640.2_3 - 8.2e-07 29.1 0.0 1.3 9.3 0.0 5.3 5 1 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Neural_ProG_Cyt PF06567.9 MSTRG.8640.2_3 - 0.09 12.9 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Neural chondroitin sulphate proteoglycan cytoplasmic domain PHD PF00628.27 MSTRG.8190.1_3 - 2e-07 30.7 8.6 4.2e-07 29.6 8.6 1.6 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.4 MSTRG.8190.1_3 - 4.5e-06 26.0 5.4 1.3e-05 24.5 5.4 1.8 1 0 0 1 1 1 1 PHD-finger C1_1 PF00130.20 MSTRG.8190.1_3 - 0.0028 17.4 1.0 0.0028 17.4 1.0 2.0 1 1 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Malic_M PF03949.13 MSTRG.1828.2_3 - 8.7e-96 320.0 0.1 1.1e-95 319.6 0.1 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.17 MSTRG.1828.2_3 - 4.2e-78 261.2 0.0 6.5e-78 260.6 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain zf-H2C2_2 PF13465.4 MSTRG.16778.1_2 - 2.7e-48 160.2 58.3 4.9e-09 36.1 0.9 10.0 10 0 0 10 10 10 8 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.16778.1_2 - 1.8e-28 97.3 72.4 5.5e-05 23.3 1.8 9.5 9 0 0 9 9 9 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.16778.1_2 - 1.7e-25 87.4 69.0 0.00072 20.1 1.0 9.5 9 0 0 9 9 9 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.16778.1_2 - 3e-13 49.2 59.5 9.4e-05 22.1 0.4 9.0 8 0 0 8 8 8 6 C2H2-type zinc finger zf-met PF12874.5 MSTRG.16778.1_2 - 6.1e-12 45.4 61.6 0.027 14.7 0.9 8.1 8 0 0 8 8 8 6 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.16778.1_2 - 0.0028 17.8 33.4 0.65 10.3 0.1 7.6 7 0 0 7 7 7 3 Zinc-finger double-stranded RNA-binding Sec8_exocyst PF04048.12 MSTRG.16778.1_2 - 0.0035 17.1 0.0 1.5 8.6 0.0 2.3 2 0 0 2 2 2 2 Sec8 exocyst complex component specific domain zf-Sec23_Sec24 PF04810.13 MSTRG.16778.1_2 - 0.019 14.9 0.4 0.019 14.9 0.4 6.9 6 2 3 9 9 9 0 Sec23/Sec24 zinc finger Zn-ribbon_8 PF09723.8 MSTRG.16778.1_2 - 0.21 11.6 0.1 0.21 11.6 0.1 5.9 2 2 4 6 6 6 0 Zinc ribbon domain BolA PF01722.16 MSTRG.16778.1_2 - 2.8 8.1 10.0 19 5.5 0.6 3.9 3 0 0 3 3 3 0 BolA-like protein UBZ_FAAP20 PF15750.3 MSTRG.20479.3_3 - 3.2e-12 46.0 1.8 3.2e-12 46.0 1.8 1.8 2 0 0 2 2 2 1 Ubiquitin-binding zinc-finger SOCS_box PF07525.14 MSTRG.26553.3_3 - 1.9e-09 37.5 9.0 6.1e-09 35.9 9.0 1.9 1 0 0 1 1 1 1 SOCS box Ank_3 PF13606.4 MSTRG.26553.3_3 - 0.03 14.7 0.1 0.29 11.7 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeat Ank_2 PF12796.5 MSTRG.26553.3_3 - 0.094 13.2 0.0 0.34 11.4 0.0 1.8 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) ECH_1 PF00378.18 MSTRG.27110.2_2 - 1.5e-45 155.4 0.1 2.3e-45 154.8 0.1 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.3 MSTRG.27110.2_2 - 9.9e-28 97.5 0.1 4.8e-27 95.2 0.1 1.8 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase SNF2_N PF00176.21 MSTRG.6491.2_1 - 5e-28 97.7 0.0 8.7e-28 96.9 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.29 MSTRG.6491.2_1 - 5.1e-13 49.2 0.0 1.3e-12 47.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HNH PF01844.21 MSTRG.6491.2_1 - 3.8e-09 36.4 3.4 7.1e-09 35.6 0.0 3.0 3 0 0 3 3 3 1 HNH endonuclease ResIII PF04851.13 MSTRG.6491.2_1 - 3e-08 33.7 0.1 9e-07 28.9 0.0 2.7 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.3 MSTRG.6491.2_1 - 0.02 13.9 0.0 0.037 13.1 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase HNH_5 PF14279.4 MSTRG.6491.2_1 - 0.046 13.4 0.0 0.046 13.4 0.0 2.3 2 0 0 2 2 2 0 HNH endonuclease zf-RanBP PF00641.16 MSTRG.6491.2_1 - 0.16 11.2 10.0 0.019 14.1 4.3 2.6 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others DUF2116 PF09889.7 MSTRG.6491.2_1 - 0.17 11.7 1.9 0.47 10.3 1.9 1.8 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) 2-Hacid_dh_C PF02826.17 MSTRG.10270.4_2 - 7.9e-54 181.6 0.0 9.9e-54 181.2 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.13 MSTRG.10270.4_2 - 9e-05 22.6 0.0 0.00013 22.0 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.18 MSTRG.10270.4_2 - 0.0021 18.0 0.0 0.0046 16.9 0.0 1.6 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.15 MSTRG.10270.4_2 - 0.0093 16.4 0.0 0.017 15.6 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent KR PF08659.8 MSTRG.10270.4_2 - 0.025 14.4 0.0 0.039 13.7 0.0 1.4 1 1 0 1 1 1 0 KR domain ThiF PF00899.19 MSTRG.10270.4_2 - 0.091 12.0 2.8 0.24 10.6 1.1 2.0 2 0 0 2 2 2 0 ThiF family RVT_1 PF00078.25 MSTRG.3784.1_3 - 7.6e-06 25.5 0.0 7.9e-06 25.4 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RRM_1 PF00076.20 MSTRG.17536.1_3 - 2.2e-14 52.9 0.0 9.9e-13 47.6 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) B12-binding_2 PF02607.15 MSTRG.17536.1_3 - 0.14 12.5 0.0 0.36 11.2 0.0 1.6 2 0 0 2 2 2 0 B12 binding domain DUF21 PF01595.18 MSTRG.27462.1_1 - 5.8e-18 65.1 0.5 8e-18 64.6 0.5 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF21 CBS PF00571.26 MSTRG.27462.1_1 - 4.2e-07 30.2 0.1 3.3e-05 24.1 0.0 2.8 3 0 0 3 3 3 1 CBS domain Dynamin_M PF01031.18 MSTRG.18919.4_2 - 1.2e-32 113.2 0.5 1.9e-32 112.5 0.1 1.5 2 0 0 2 2 2 1 Dynamin central region GED PF02212.16 MSTRG.18919.4_2 - 7.4e-26 90.0 2.1 7.4e-26 90.0 2.1 1.6 2 0 0 2 2 2 1 Dynamin GTPase effector domain PH PF00169.27 MSTRG.18919.4_2 - 1.1e-12 48.3 0.5 1.9e-12 47.5 0.5 1.4 1 0 0 1 1 1 1 PH domain Dynamin_M PF01031.18 MSTRG.18919.4_3 - 1.8e-18 66.6 0.1 2.5e-18 66.2 0.1 1.1 1 0 0 1 1 1 1 Dynamin central region Aminotran_1_2 PF00155.19 MSTRG.4558.1_2 - 6.3e-42 143.9 0.0 7.3e-42 143.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II FAO_M PF16350.3 MSTRG.4558.1_2 - 0.058 13.6 0.0 0.16 12.2 0.0 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase central domain Beta_elim_lyase PF01212.19 MSTRG.4558.1_2 - 0.23 10.6 0.0 0.32 10.1 0.0 1.1 1 0 0 1 1 1 0 Beta-eliminating lyase Ank_4 PF13637.4 MSTRG.27726.1_3 - 5.4e-40 135.1 5.9 4.8e-12 46.0 0.1 5.4 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_2 PF12796.5 MSTRG.27726.1_3 - 3.1e-39 133.3 0.5 2.5e-13 50.3 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.27726.1_3 - 5.1e-36 122.0 1.2 8e-09 35.5 0.0 5.7 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.27726.1_3 - 2.2e-30 101.2 1.5 1.1e-06 28.4 0.1 6.6 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.28 MSTRG.27726.1_3 - 1.5e-27 94.7 15.0 1.5e-06 28.2 0.1 7.4 8 0 0 8 8 8 5 Ankyrin repeat Caskin1-CID PF16600.3 MSTRG.27726.1_3 - 2.8e-21 75.7 12.8 3.2e-15 56.3 1.8 3.2 4 0 0 4 4 4 2 Caskin1 CASK-interaction domain SH3_2 PF07653.15 MSTRG.27726.1_3 - 1e-08 34.6 0.0 2e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 MSTRG.27726.1_3 - 1.4e-05 24.7 0.0 2.4e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.27726.1_3 - 5.1e-05 22.7 0.0 9.8e-05 21.8 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SAM_1 PF00536.28 MSTRG.27726.1_3 - 0.0033 17.7 0.0 0.007 16.7 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Rap_GAP PF02145.13 MSTRG.7824.1_3 - 6.7e-65 218.0 0.0 1.1e-64 217.3 0.0 1.4 1 0 0 1 1 1 1 Rap/ran-GAP PDZ PF00595.22 MSTRG.7824.1_3 - 2.7e-05 24.3 0.0 5.8e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Pkinase PF00069.23 MSTRG.5963.1_2 - 2.6e-77 259.6 0.1 4.9e-77 258.7 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.5963.1_2 - 3.1e-37 128.2 0.0 4.6e-37 127.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 MSTRG.5963.1_2 - 2.9e-05 23.4 0.7 0.00023 20.5 0.2 2.3 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family HIP1_clath_bdg PF16515.3 MSTRG.5963.1_2 - 0.025 15.0 1.3 0.025 15.0 1.3 2.9 3 1 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Reo_sigmaC PF04582.10 MSTRG.5963.1_2 - 0.074 12.3 0.1 0.14 11.4 0.1 1.4 1 0 0 1 1 1 0 Reovirus sigma C capsid protein HALZ PF02183.16 MSTRG.5963.1_2 - 0.11 12.5 2.6 0.54 10.4 0.0 3.1 3 0 0 3 3 3 0 Homeobox associated leucine zipper DUF1664 PF07889.10 MSTRG.5963.1_2 - 0.42 10.5 6.3 0.13 12.1 0.7 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Vps51 PF08700.9 MSTRG.5963.1_2 - 3.6 7.6 7.2 2.1 8.3 0.1 3.4 4 1 0 4 4 4 0 Vps51/Vps67 AXH PF08517.10 MSTRG.14446.2_2 - 1.9e-30 105.6 0.0 3.1e-30 104.9 0.0 1.3 1 0 0 1 1 1 1 Ataxin-1 and HBP1 module (AXH) VapB_antitoxin PF09957.7 MSTRG.9248.1_1 - 0.028 14.2 0.0 0.053 13.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial antitoxin of type II TA system, VapB L_HMGIC_fpl PF10242.7 MSTRG.9248.1_3 - 3.7e-60 203.1 5.3 5.4e-60 202.6 5.3 1.2 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein PMP22_Claudin PF00822.18 MSTRG.9248.1_3 - 0.7 9.6 8.0 1.3 8.7 8.0 1.4 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 MSTRG.9248.1_3 - 1.9 8.1 10.1 8.6 5.9 10.4 1.8 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction HEAT PF02985.20 MSTRG.3900.1_3 - 0.036 14.1 0.0 0.15 12.2 0.0 2.1 1 0 0 1 1 1 0 HEAT repeat FA_desaturase PF00487.22 MSTRG.1510.1_3 - 6.8e-15 55.5 18.8 6.8e-15 55.5 18.8 1.8 1 1 1 2 2 2 1 Fatty acid desaturase Pex14_N PF04695.11 MSTRG.1510.1_3 - 0.028 15.0 0.2 0.049 14.2 0.2 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Cyto_heme_lyase PF01265.15 MSTRG.21985.1_1 - 6.7e-72 242.4 9.4 1.8e-71 240.9 9.3 1.5 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase PKcGMP_CC PF16808.3 MSTRG.16315.1_2 - 0.25 11.1 0.9 0.42 10.4 0.9 1.4 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Macoilin PF09726.7 MSTRG.16315.1_3 - 7.2 4.9 10.1 9.3 4.5 10.1 1.2 1 0 0 1 1 1 0 Transmembrane protein IMS PF00817.18 MSTRG.28651.1_1 - 2.2e-06 27.6 0.1 2.9e-06 27.2 0.1 1.2 1 0 0 1 1 1 1 impB/mucB/samB family RRM_1 PF00076.20 MSTRG.7430.1_2 - 1.8e-29 101.2 0.0 5.2e-12 45.3 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF PF08080.10 MSTRG.7430.1_2 - 9.1e-08 31.8 2.6 2.7e-07 30.3 2.6 1.9 1 0 0 1 1 1 1 RNPHF zinc finger Folate_rec PF03024.12 MSTRG.25998.1_2 - 1.4e-49 168.1 16.8 1.8e-49 167.8 16.8 1.1 1 0 0 1 1 1 1 Folate receptor family Ig_3 PF13927.4 MSTRG.21588.1_2 - 4.8e-75 248.1 0.0 1.8e-12 47.6 0.0 6.8 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.14 MSTRG.21588.1_2 - 1e-66 220.8 0.0 5.2e-13 48.8 0.0 7.0 6 1 0 6 6 6 6 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.21588.1_2 - 1.5e-57 191.7 0.1 1.6e-11 44.2 0.0 6.5 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.23 MSTRG.21588.1_2 - 9.9e-56 185.8 0.0 9.4e-11 41.6 0.0 7.3 6 1 0 6 6 6 6 Immunoglobulin domain fn3 PF00041.19 MSTRG.21588.1_2 - 2.7e-38 130.1 6.8 3.9e-13 49.4 0.1 4.8 4 0 0 4 4 4 4 Fibronectin type III domain V-set PF07686.15 MSTRG.21588.1_2 - 6.3e-24 84.1 6.1 0.0032 17.5 0.0 9.6 7 5 2 9 9 9 5 Immunoglobulin V-set domain Ig_5 PF16681.3 MSTRG.21588.1_2 - 8.5e-11 42.0 0.1 0.38 11.1 0.0 6.3 6 0 0 6 6 6 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.10 MSTRG.21588.1_2 - 5.1e-09 36.0 0.1 0.00024 21.0 0.0 4.6 4 1 1 5 5 5 2 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.3 MSTRG.21588.1_2 - 9.9e-07 28.9 0.0 2 8.7 0.0 5.7 6 0 0 6 6 6 1 T-cell surface glycoprotein CD3 delta chain Pur_ac_phosph_N PF16656.3 MSTRG.21588.1_2 - 7.6e-06 26.3 3.1 0.0055 17.1 0.2 3.2 3 0 0 3 3 2 2 Purple acid Phosphatase, N-terminal domain Izumo-Ig PF16706.3 MSTRG.21588.1_2 - 3.9e-05 23.5 0.0 2.9 7.9 0.0 5.3 5 0 0 5 5 5 1 Izumo-like Immunoglobulin domain C1-set PF07654.13 MSTRG.21588.1_2 - 0.0032 17.8 0.0 13 6.2 0.0 4.1 4 0 0 4 4 3 0 Immunoglobulin C1-set domain Adeno_E3_CR1 PF02440.13 MSTRG.21588.1_2 - 0.0041 16.7 0.1 5.3 6.8 0.0 5.1 6 0 0 6 6 6 1 Adenovirus E3 region protein CR1 V-set_CD47 PF08204.9 MSTRG.21588.1_2 - 0.0078 16.1 0.2 7.5 6.4 0.0 4.5 5 0 0 5 5 5 1 CD47 immunoglobulin-like domain BiPBP_C PF06832.10 MSTRG.21588.1_2 - 0.018 14.9 0.0 7.1 6.6 0.0 3.9 4 0 0 4 4 4 0 Penicillin-Binding Protein C-terminus Family DP-EP PF08985.9 MSTRG.21588.1_2 - 0.18 11.8 0.1 0.42 10.7 0.1 1.5 1 0 0 1 1 1 0 DP-EP family IL15 PF02372.13 MSTRG.640.1_3 - 2.8e-10 40.2 0.2 6.5e-10 39.0 0.2 1.6 1 0 0 1 1 1 1 Interleukin 15 Ion_trans PF00520.29 MSTRG.4768.1_2 - 1.1e-41 142.5 2.7 1.4e-41 142.3 2.7 1.0 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.10 MSTRG.4768.1_2 - 0.27 9.7 5.4 0.29 9.6 0.5 2.1 1 1 1 2 2 2 0 Polycystin cation channel Peptidase_M14 PF00246.22 MSTRG.29065.1_3 - 1.7e-34 119.8 0.0 1.9e-34 119.7 0.0 1.0 1 0 0 1 1 1 1 Zinc carboxypeptidase F-box PF00646.31 MSTRG.8247.1_1 - 0.063 13.1 0.2 0.1 12.4 0.2 1.3 1 0 0 1 1 1 0 F-box domain PH PF00169.27 MSTRG.26783.5_3 - 0.00033 21.0 0.0 0.00082 19.7 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_10 PF15411.4 MSTRG.26783.5_3 - 0.015 15.4 0.3 0.04 14.0 0.3 1.7 1 1 0 1 1 1 0 Pleckstrin homology domain IQ_SEC7_PH PF16453.3 MSTRG.26783.5_3 - 0.037 13.9 0.0 0.066 13.1 0.0 1.3 1 0 0 1 1 1 0 PH domain VWA PF00092.26 MSTRG.15342.1_1 - 2.1e-07 31.3 0.1 2.8e-07 30.9 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain fn3 PF00041.19 MSTRG.15342.1_1 - 0.014 15.6 0.5 0.034 14.4 0.0 1.9 2 0 0 2 2 2 0 Fibronectin type III domain VWA_2 PF13519.4 MSTRG.15342.1_1 - 0.05 14.1 0.0 0.08 13.5 0.0 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain eRF1_2 PF03464.13 MSTRG.10360.2_2 - 1.9e-46 157.6 0.1 3.2e-46 156.8 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.13 MSTRG.10360.2_2 - 4.1e-38 130.2 0.2 8.3e-38 129.2 0.2 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.13 MSTRG.10360.2_2 - 4.6e-19 68.6 0.0 9.9e-19 67.5 0.0 1.6 1 0 0 1 1 1 1 eRF1 domain 1 Ribosomal_L7Ae PF01248.24 MSTRG.10360.2_2 - 0.12 12.0 0.0 0.28 10.8 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family NHR2 PF08788.9 MSTRG.23276.2_3 - 1.4e-37 127.1 9.0 4.1e-37 125.6 9.0 1.8 1 0 0 1 1 1 1 NHR2 domain like TAFH PF07531.12 MSTRG.23276.2_3 - 7.3e-34 115.5 1.2 1.4e-33 114.6 1.2 1.5 1 0 0 1 1 1 1 NHR1 homology to TAF Spore_III_AB PF09548.8 MSTRG.23276.2_3 - 0.12 12.3 0.7 0.25 11.3 0.7 1.4 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) AD PF09793.7 MSTRG.4779.1_2 - 7.1e-25 86.8 0.5 1.4e-24 85.9 0.5 1.5 1 0 0 1 1 1 1 Anticodon-binding domain Pro_isomerase PF00160.19 MSTRG.6304.4_2 - 2.5e-24 86.2 0.0 3.2e-24 85.9 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Nucleoside_tran PF01733.16 MSTRG.25984.2_1 - 8.1e-92 307.8 6.2 1.8e-91 306.6 6.2 1.6 1 0 0 1 1 1 1 Nucleoside transporter Pkinase PF00069.23 MSTRG.13576.5_3 - 4e-73 245.9 0.0 4.9e-73 245.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.13576.5_3 - 8.7e-34 116.8 0.0 1.2e-33 116.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.13576.5_3 - 1.7e-08 34.0 0.0 2.7e-08 33.4 0.0 1.4 1 1 0 1 1 1 1 Kinase-like APH PF01636.21 MSTRG.13576.5_3 - 0.15 11.9 0.1 2.8 7.7 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF4203 PF13886.4 MSTRG.20618.1_2 - 1.6e-39 135.6 35.1 2.5e-39 134.9 35.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) Integrin_alpha2 PF08441.10 MSTRG.3410.1_2 - 1.5e-101 340.5 0.8 1.9e-101 340.1 0.8 1.1 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.21 MSTRG.3410.1_2 - 4.3e-16 58.6 22.6 1.9e-09 37.4 4.4 3.8 3 0 0 3 3 3 3 FG-GAP repeat VCBS PF13517.4 MSTRG.3410.1_2 - 4.9e-11 42.9 13.6 6.4e-09 36.1 2.0 3.5 1 1 3 4 4 4 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TMEM190 PF15431.4 MSTRG.3410.1_2 - 0.064 13.3 1.7 0.19 11.7 1.7 1.8 1 0 0 1 1 1 0 Transmembrane protein 190 THUMP PF02926.15 MSTRG.27474.1_2 - 6.6e-15 55.3 0.1 1.5e-14 54.2 0.1 1.6 1 0 0 1 1 1 1 THUMP domain SNAP-25 PF00835.17 MSTRG.5373.2_3 - 2.2e-14 53.4 0.5 4.9e-14 52.2 0.5 1.7 1 0 0 1 1 1 1 SNAP-25 family DUF5089 PF17002.3 MSTRG.5373.2_3 - 5.5e-06 26.3 2.5 1.3e-05 25.0 2.5 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF5089) Spc7 PF08317.9 MSTRG.5373.2_3 - 0.09 11.5 6.4 0.07 11.9 1.1 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Snapin_Pallidin PF14712.4 MSTRG.5373.2_3 - 0.23 11.8 7.3 2.1 8.7 3.0 2.4 2 1 0 2 2 2 0 Snapin/Pallidin DUF4446 PF14584.4 MSTRG.5373.2_3 - 0.79 9.6 4.1 7.9 6.3 0.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF4446) Alanine_zipper PF11839.6 MSTRG.5373.2_3 - 0.82 9.9 6.7 2.5 8.3 0.1 3.1 2 1 0 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein Exonuc_VII_L PF02601.13 MSTRG.5373.2_3 - 0.86 9.0 7.7 0.44 9.9 0.8 2.0 1 1 1 2 2 2 0 Exonuclease VII, large subunit XhlA PF10779.7 MSTRG.5373.2_3 - 1.3 9.2 12.7 5.4 7.2 2.0 3.2 2 1 1 3 3 3 0 Haemolysin XhlA DUF1664 PF07889.10 MSTRG.5373.2_3 - 1.3 8.9 6.0 4.9 7.0 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Laminin_II PF06009.10 MSTRG.5373.2_3 - 1.4 8.8 6.3 5.9 6.8 0.7 2.4 2 1 0 2 2 2 0 Laminin Domain II DUF16 PF01519.14 MSTRG.5373.2_3 - 1.5 9.2 6.1 9.8 6.6 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF948 PF06103.9 MSTRG.5373.2_3 - 2.2 8.5 4.9 31 4.8 0.2 3.0 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Transposase_22 PF02994.12 MSTRG.5373.2_3 - 2.6 6.7 8.3 0.088 11.5 2.1 1.5 2 0 0 2 2 2 0 L1 transposable element V-SNARE_C PF12352.6 MSTRG.5373.2_3 - 2.9 8.1 8.7 0.27 11.4 0.5 3.2 3 2 0 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus SNARE PF05739.17 MSTRG.5373.2_3 - 3.2 7.7 6.2 3.3 7.7 0.7 2.5 2 0 0 2 2 2 0 SNARE domain Use1 PF09753.7 MSTRG.5373.2_3 - 6.6 6.2 10.1 0.22 11.1 0.9 2.3 2 0 0 2 2 2 0 Membrane fusion protein Use1 DUF4200 PF13863.4 MSTRG.5373.2_3 - 7.3 6.9 10.6 9 6.6 0.5 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) PH PF00169.27 MSTRG.24.1_3 - 1.2e-05 25.6 0.3 3.8e-05 24.0 0.1 2.1 2 0 0 2 2 2 1 PH domain Gtr1_RagA PF04670.10 MSTRG.15376.3_1 - 6.3e-38 130.3 1.5 8.3e-38 129.9 1.5 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Gtr1_RagA PF04670.10 MSTRG.15376.3_3 - 7.4e-59 198.8 0.6 9.5e-59 198.4 0.6 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.11 MSTRG.15376.3_3 - 0.00013 22.0 0.0 0.00022 21.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 MSTRG.15376.3_3 - 0.0002 20.7 0.0 0.00028 20.2 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.19 MSTRG.15376.3_3 - 0.00086 18.7 0.0 0.0013 18.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.20 MSTRG.15376.3_3 - 0.0014 18.1 0.1 0.002 17.6 0.1 1.2 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.21 MSTRG.15376.3_3 - 0.044 13.7 0.0 0.069 13.1 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.4 MSTRG.15376.3_3 - 0.048 13.9 0.0 0.093 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Peptidase_M1 PF01433.18 MSTRG.24183.1_3 - 1.4e-76 258.2 0.0 1.8e-76 257.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M1 Leuk-A4-hydro_C PF09127.9 MSTRG.24183.1_3 - 1.6e-45 154.5 0.0 2.7e-45 153.7 0.0 1.4 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal ATP-gua_Ptrans PF00217.17 MSTRG.11142.1_2 - 2.2e-45 155.1 0.0 3.5e-22 79.1 0.0 2.2 2 0 0 2 2 2 2 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.13 MSTRG.11142.1_2 - 5.8e-32 109.8 0.0 9.8e-32 109.1 0.0 1.4 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain AMP-binding_C PF13193.4 MSTRG.16708.1_2 - 0.1 13.5 0.0 0.17 12.8 0.0 1.4 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Ank_4 PF13637.4 MSTRG.15971.1_3 - 1.3e-48 162.6 9.6 1.6e-13 50.7 0.1 4.8 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.5 MSTRG.15971.1_3 - 6.4e-44 148.3 4.8 2.2e-16 60.1 0.1 3.6 2 2 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.28 MSTRG.15971.1_3 - 2.3e-42 141.5 3.7 5.3e-09 36.0 0.1 5.7 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.4 MSTRG.15971.1_3 - 3.5e-39 132.1 11.3 5.2e-11 42.4 0.2 4.7 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.15971.1_3 - 1.3e-36 120.3 2.0 3.6e-07 29.8 0.1 5.4 5 0 0 5 5 5 5 Ankyrin repeat HlyIII PF03006.18 MSTRG.19429.1_2 - 1.2e-24 87.1 12.7 1.9e-24 86.5 12.7 1.3 1 0 0 1 1 1 1 Haemolysin-III related COE1_DBD PF16422.3 MSTRG.16048.1_3 - 2.4e-146 485.1 1.2 3.6e-146 484.5 1.2 1.3 1 0 0 1 1 1 1 Transcription factor COE1 DNA-binding domain COE1_HLH PF16423.3 MSTRG.16048.1_3 - 1e-34 117.9 1.8 1.3e-28 98.3 0.3 2.5 2 0 0 2 2 2 2 Transcription factor COE1 helix-loop-helix domain TIG PF01833.22 MSTRG.16048.1_3 - 3e-12 46.3 0.3 7.7e-12 45.0 0.3 1.7 1 0 0 1 1 1 1 IPT/TIG domain MOR2-PAG1_N PF14222.4 MSTRG.7194.2_1 - 4.3e-12 45.6 0.0 6.1e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 Cell morphogenesis N-terminal DUF3456 PF11938.6 MSTRG.15699.1_2 - 1.1e-38 133.1 0.0 1.5e-38 132.6 0.0 1.2 1 0 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP SMC_N PF02463.17 MSTRG.9992.2_1 - 7.8e-80 267.3 0.1 1.6e-79 266.3 0.1 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.11 MSTRG.9992.2_1 - 2.5e-23 82.5 0.0 7.9e-23 80.9 0.0 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.4 MSTRG.9992.2_1 - 1.3e-11 44.7 1.8 4.1e-05 23.4 0.0 3.0 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system HMMR_N PF15905.3 MSTRG.9992.2_1 - 0.00021 20.7 21.8 0.00021 20.7 21.8 6.1 2 2 4 6 6 5 1 Hyaluronan mediated motility receptor N-terminal AAA_29 PF13555.4 MSTRG.9992.2_1 - 0.00036 20.0 0.0 0.0008 19.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain TPR_MLP1_2 PF07926.10 MSTRG.9992.2_1 - 0.0006 19.8 17.1 0.0006 19.8 17.1 7.9 3 2 4 8 8 7 1 TPR/MLP1/MLP2-like protein Reo_sigmaC PF04582.10 MSTRG.9992.2_1 - 0.0007 19.0 41.8 0.039 13.2 4.5 5.3 2 2 2 5 5 5 3 Reovirus sigma C capsid protein Tropomyosin_1 PF12718.5 MSTRG.9992.2_1 - 0.0029 17.6 12.8 0.0029 17.6 12.8 7.9 3 2 4 7 7 6 1 Tropomyosin like ABC_tran PF00005.25 MSTRG.9992.2_1 - 0.58 10.5 0.0 0.58 10.5 0.0 6.6 5 2 0 5 5 3 0 ABC transporter Myosin_tail_1 PF01576.17 MSTRG.9992.2_1 - 0.73 7.4 120.8 0.12 10.0 68.7 2.7 2 1 0 2 2 2 0 Myosin tail AAA_23 PF13476.4 MSTRG.9992.2_1 - 1.5 9.1 116.2 5.9e+03 -2.6 2.8 6.7 3 2 0 3 3 1 0 AAA domain Peptidase_C1 PF00112.21 MSTRG.6126.1_3 - 1.7e-78 263.6 0.4 2.1e-78 263.3 0.4 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 MSTRG.6126.1_3 - 8.5e-13 48.4 0.1 1.4e-12 47.7 0.1 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 MSTRG.6126.1_3 - 0.0003 19.5 0.2 0.041 12.5 0.1 2.2 2 0 0 2 2 2 2 Peptidase C1-like family C2 PF00168.28 MSTRG.22763.1_2 - 2.7e-10 40.3 0.0 8e-10 38.8 0.0 1.8 2 0 0 2 2 2 1 C2 domain DUF2706 PF10913.6 MSTRG.22763.1_2 - 0.11 12.2 0.1 0.4 10.4 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2706) Pkinase PF00069.23 MSTRG.1574.1_3 - 1.6e-36 125.9 0.0 1.8e-36 125.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.1574.1_3 - 1.2e-24 86.8 0.0 1.4e-24 86.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.1574.1_3 - 5.4e-07 29.1 0.0 7.4e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like CENP-F_leu_zip PF10473.7 MSTRG.17419.4_1 - 0.011 15.6 10.9 0.11 12.4 2.5 2.6 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Lebercilin PF15619.4 MSTRG.17419.4_1 - 0.012 15.1 10.0 0.027 14.0 10.0 1.5 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF342 PF03961.11 MSTRG.17419.4_1 - 0.024 13.1 1.0 0.035 12.6 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) APG6 PF04111.10 MSTRG.17419.4_1 - 0.16 11.2 8.3 0.29 10.3 8.3 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 Mod_r PF07200.11 MSTRG.17419.4_1 - 0.17 11.8 7.0 0.47 10.4 7.0 1.7 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein IncA PF04156.12 MSTRG.17419.4_1 - 0.18 11.4 9.3 0.4 10.3 9.3 1.7 1 0 0 1 1 1 0 IncA protein DUF4164 PF13747.4 MSTRG.17419.4_1 - 0.7 10.1 5.0 0.52 10.5 1.9 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4164) Rho_Binding PF08912.9 MSTRG.17419.4_1 - 1.1 10.0 6.1 0.78 10.5 3.5 2.2 2 0 0 2 2 2 0 Rho Binding Laminin_II PF06009.10 MSTRG.17419.4_1 - 1.1 9.1 5.4 1.4 8.8 0.3 2.5 1 1 1 2 2 2 0 Laminin Domain II KxDL PF10241.7 MSTRG.17419.4_1 - 1.6 8.9 6.6 2.9 8.1 2.2 3.1 2 1 1 3 3 3 0 Uncharacterized conserved protein Occludin_ELL PF07303.11 MSTRG.17419.4_1 - 1.7 9.3 8.2 27 5.4 4.5 3.3 2 1 1 3 3 3 0 Occludin homology domain Tropomyosin_1 PF12718.5 MSTRG.17419.4_1 - 2.4 8.1 16.2 1.7 8.6 12.1 2.5 2 1 1 3 3 3 0 Tropomyosin like DUF4140 PF13600.4 MSTRG.17419.4_1 - 4.9 7.5 8.6 1.7 9.0 2.5 3.0 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF59 PF01883.17 MSTRG.25142.1_3 - 3.6e-07 30.1 0.0 1.2e-06 28.5 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function DUF59 Metallophos_2 PF12850.5 MSTRG.1261.4_1 - 2.5e-12 47.2 0.0 3.5e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_2 PF12850.5 MSTRG.1261.4_3 - 5e-05 23.4 0.1 0.00011 22.4 0.0 1.5 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain ShK PF01549.22 MSTRG.1261.4_3 - 0.2 12.1 1.4 0.64 10.5 1.4 1.8 1 0 0 1 1 1 0 ShK domain-like Mito_fiss_reg PF05308.9 MSTRG.15795.1_1 - 4.7 7.1 5.8 6 6.7 5.8 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator Laminin_EGF PF00053.22 MSTRG.3273.3_1 - 4.3e-19 68.3 33.4 3.2e-13 49.5 12.5 6.7 5 2 1 6 6 6 2 Laminin EGF domain Kazal_2 PF07648.13 MSTRG.3273.3_1 - 2.8e-16 59.3 22.4 6.5e-10 38.9 3.2 3.4 3 0 0 3 3 3 2 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 MSTRG.3273.3_1 - 1.9e-09 37.2 30.7 4.2e-06 26.5 6.0 3.4 3 0 0 3 3 3 2 Kazal-type serine protease inhibitor domain Glyco_transf_18 PF15024.4 MSTRG.27817.1_1 - 1.1e-27 96.7 0.0 1.8e-27 96.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 18 Calcyon PF06387.9 MSTRG.11452.1_3 - 7.3e-66 221.5 0.2 9.2e-66 221.2 0.2 1.1 1 0 0 1 1 1 1 D1 dopamine receptor-interacting protein (calcyon) TyeA PF09059.8 MSTRG.28302.1_2 - 0.084 12.9 0.0 0.1 12.6 0.0 1.1 1 0 0 1 1 1 0 TyeA DnaB_bind PF10410.7 MSTRG.28302.1_2 - 0.14 12.2 0.0 0.19 11.8 0.0 1.2 1 0 0 1 1 1 0 DnaB-helicase binding domain of primase Ank_2 PF12796.5 MSTRG.9116.1_2 - 4.5e-166 539.8 82.3 4.8e-17 62.2 0.3 14.0 1 1 17 18 18 18 18 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.9116.1_2 - 9.3e-147 475.6 50.8 1.2e-14 54.3 0.4 19.8 8 4 12 21 21 21 20 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.9116.1_2 - 1.5e-132 426.7 77.8 8.2e-07 29.1 0.0 28.0 28 0 0 28 28 28 26 Ankyrin repeat Ank_5 PF13857.4 MSTRG.9116.1_2 - 4.1e-118 383.2 61.7 5.4e-10 39.2 0.0 20.9 7 4 16 23 23 23 23 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.9116.1_2 - 4.6e-109 342.9 58.4 3.1e-06 27.0 0.1 27.8 28 0 0 28 28 28 26 Ankyrin repeat Nop53 PF07767.9 MSTRG.27178.1_2 - 3.1e-91 306.6 47.4 3.9e-91 306.2 47.4 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) PCNP PF15473.4 MSTRG.17505.1_1 - 9.3e-57 192.0 8.9 1.2e-56 191.6 8.9 1.1 1 0 0 1 1 1 1 PEST, proteolytic signal-containing nuclear protein family VWA PF00092.26 MSTRG.24405.10_1 - 2e-49 168.0 0.3 3.8e-47 160.7 0.0 2.0 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.4 MSTRG.24405.10_1 - 6.6e-17 62.0 0.0 1.1e-16 61.3 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.4 MSTRG.24405.10_1 - 0.0066 16.2 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain RasGAP PF00616.17 MSTRG.24405.10_1 - 0.2 11.2 1.1 2.7 7.5 0.1 2.1 2 0 0 2 2 2 0 GTPase-activator protein for Ras-like GTPase NUC129 PF08157.9 MSTRG.10472.3_2 - 1.3e-25 89.4 0.1 2.6e-25 88.4 0.1 1.6 1 0 0 1 1 1 1 NUC129 domain RAI16-like PF10257.7 MSTRG.8550.1_1 - 3.5e-78 262.9 2.3 4.4e-78 262.5 2.3 1.1 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein Pkinase PF00069.23 MSTRG.8557.1_3 - 4.2e-72 242.6 0.0 6.2e-72 242.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 MSTRG.8557.1_3 - 4.2e-57 190.0 0.0 5.4e-26 90.4 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.8557.1_3 - 1.1e-34 118.8 0.2 6e-13 49.1 0.0 4.0 4 0 0 4 4 4 3 Immunoglobulin domain Pkinase_Tyr PF07714.15 MSTRG.8557.1_3 - 9.8e-33 113.4 0.0 1.6e-32 112.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_2 PF13895.4 MSTRG.8557.1_3 - 5.3e-17 61.8 0.2 2.1e-05 24.7 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 MSTRG.8557.1_3 - 6.7e-16 58.1 2.6 1.2e-05 25.3 0.0 3.9 4 0 0 4 4 4 3 Immunoglobulin domain fn3 PF00041.19 MSTRG.8557.1_3 - 7.6e-12 45.3 0.2 1.9e-11 44.0 0.2 1.7 1 0 0 1 1 1 1 Fibronectin type III domain V-set PF07686.15 MSTRG.8557.1_3 - 1.2e-08 34.9 1.1 0.3 11.1 0.1 5.4 3 3 0 3 3 3 2 Immunoglobulin V-set domain Kinase-like PF14531.4 MSTRG.8557.1_3 - 0.0014 17.9 0.0 0.0023 17.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like C2-set_2 PF08205.10 MSTRG.8557.1_3 - 0.057 13.4 0.0 0.54 10.2 0.0 2.6 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain Mob1_phocein PF03637.15 MSTRG.22132.6_1 - 1.9e-25 89.7 0.5 2.9e-25 89.1 0.5 1.3 1 0 0 1 1 1 1 Mob1/phocein family CEP170_C PF15308.4 MSTRG.21512.1_2 - 0.14 10.6 3.1 0.2 10.0 3.1 1.1 1 0 0 1 1 1 0 CEP170 C-terminus DnaJ PF00226.29 MSTRG.3393.1_1 - 5.5e-19 67.9 0.8 5.5e-19 67.9 0.8 2.0 2 0 0 2 2 2 1 DnaJ domain A_deamin PF02137.16 MSTRG.12555.3_3 - 4.3e-103 345.1 0.0 6.7e-103 344.4 0.0 1.3 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain dsrm PF00035.24 MSTRG.12555.3_3 - 2.2e-29 101.8 0.8 7.2e-08 32.9 0.0 4.7 4 0 0 4 4 4 4 Double-stranded RNA binding motif z-alpha PF02295.15 MSTRG.12555.3_3 - 1.2e-19 70.0 0.6 2.6e-09 36.9 0.1 2.5 2 0 0 2 2 2 2 Adenosine deaminase z-alpha domain HTH_9 PF08221.9 MSTRG.12555.3_3 - 0.03 14.3 1.8 4.9 7.2 0.2 2.6 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 helix-turn-helix domain zf-C3HC4_2 PF13923.4 MSTRG.16028.3_2 - 1.9e-16 59.5 27.3 2e-11 43.4 11.7 3.2 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.16028.3_2 - 1.3e-14 53.8 22.6 1.2e-09 37.9 8.5 3.1 2 1 0 2 2 2 2 RING-type zinc-finger zf-C3HC4_4 PF15227.4 MSTRG.16028.3_2 - 2.8e-14 52.9 25.5 1.3e-08 34.7 10.7 3.4 2 0 0 2 2 2 2 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 MSTRG.16028.3_2 - 4.7e-14 51.9 22.0 3.8e-09 36.1 7.3 2.7 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 MSTRG.16028.3_2 - 1.9e-12 46.7 27.8 5.8e-08 32.3 11.5 2.9 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 MSTRG.16028.3_2 - 7.4e-11 41.7 27.4 1.5e-06 27.9 10.7 3.0 2 0 0 2 2 2 2 zinc-RING finger domain zf-RING_2 PF13639.4 MSTRG.16028.3_2 - 8.6e-11 41.8 29.0 1.9e-07 31.1 11.9 3.1 2 0 0 2 2 2 2 Ring finger domain Prok-RING_4 PF14447.4 MSTRG.16028.3_2 - 2.4e-09 36.8 22.1 2.1e-06 27.3 8.5 2.7 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_10 PF16685.3 MSTRG.16028.3_2 - 5.6e-06 26.3 25.3 0.00089 19.2 8.0 2.6 2 0 0 2 2 2 2 zinc RING finger of MSL2 LON_substr_bdg PF02190.14 MSTRG.16028.3_2 - 7.7e-05 22.5 0.0 0.00016 21.5 0.0 1.5 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain U-box PF04564.13 MSTRG.16028.3_2 - 0.00024 21.1 0.0 0.0032 17.5 0.0 2.2 2 0 0 2 2 2 1 U-box domain zf-RING_6 PF14835.4 MSTRG.16028.3_2 - 0.00032 20.4 16.5 0.0039 16.9 2.5 2.7 3 0 0 3 3 2 2 zf-RING of BARD1-type protein zf-Nse PF11789.6 MSTRG.16028.3_2 - 0.00085 19.0 20.9 0.0057 16.3 9.1 3.0 2 1 1 3 3 3 2 Zinc-finger of the MIZ type in Nse subunit TPR_9 PF13371.4 MSTRG.16028.3_2 - 0.0029 17.6 0.7 0.021 14.8 0.6 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat zf-rbx1 PF12678.5 MSTRG.16028.3_2 - 0.0054 16.9 23.1 0.017 15.3 11.7 3.5 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_4 PF14570.4 MSTRG.16028.3_2 - 0.054 13.1 20.0 0.32 10.6 9.1 3.4 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain TPR_14 PF13428.4 MSTRG.16028.3_2 - 0.063 14.0 0.0 0.16 12.7 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF1272 PF06906.9 MSTRG.16028.3_2 - 0.94 9.5 22.9 0.56 10.2 6.2 3.3 3 1 1 4 4 3 0 Protein of unknown function (DUF1272) KH_1 PF00013.27 MSTRG.16795.1_1 - 1.6e-67 223.1 8.4 2e-16 59.4 0.1 4.3 4 0 0 4 4 4 4 KH domain KH_2 PF07650.15 MSTRG.16795.1_1 - 2.2e-19 68.9 8.0 8.3e-05 22.2 0.0 4.2 4 0 0 4 4 4 4 KH domain KH_4 PF13083.4 MSTRG.16795.1_1 - 1.5e-09 37.4 6.2 0.032 14.0 0.0 4.4 4 0 0 4 4 4 3 KH domain DUF1897 PF09005.8 MSTRG.16795.1_1 - 0.0022 17.3 11.0 0.07 12.5 2.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF1897) Secretin_N PF03958.15 MSTRG.16795.1_1 - 0.025 14.8 0.0 0.18 12.1 0.0 2.3 2 0 0 2 2 2 0 Bacterial type II/III secretion system short domain DUF4951 PF16309.3 MSTRG.16795.1_1 - 0.32 10.9 1.2 2.1 8.3 0.5 2.3 2 0 0 2 2 2 0 Domian of unknown function (DUF4951) KH_5 PF13184.4 MSTRG.16795.1_1 - 3.9 7.5 11.1 55 3.8 0.3 4.2 4 0 0 4 4 4 0 NusA-like KH domain START PF01852.17 MSTRG.8003.1_1 - 1.2e-28 99.8 0.1 1.7e-28 99.4 0.1 1.1 1 0 0 1 1 1 1 START domain DUF3074 PF11274.6 MSTRG.8003.1_1 - 0.0079 16.1 0.0 0.013 15.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) Mito_carr PF00153.25 MSTRG.12055.1_1 - 1.2e-69 230.2 0.7 1.6e-22 79.1 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Myosin_tail_1 PF01576.17 MSTRG.26006.1_3 - 0 1702.8 308.7 0 1702.5 308.7 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.19 MSTRG.26006.1_3 - 0 1012.2 1.9 0 1012.2 1.9 3.4 4 1 0 4 4 4 1 Myosin head (motor domain) Myosin_N PF02736.17 MSTRG.26006.1_3 - 8.3e-11 41.4 0.2 1.7e-10 40.4 0.2 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain IQ PF00612.25 MSTRG.26006.1_3 - 0.00011 21.5 0.4 0.00043 19.7 0.4 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif AAA_22 PF13401.4 MSTRG.26006.1_3 - 0.12 12.6 0.0 0.12 12.6 0.0 5.6 4 2 2 6 6 6 0 AAA domain LRR_8 PF13855.4 MSTRG.3574.1_2 - 3.1e-52 174.0 32.3 9.1e-15 54.0 2.1 6.3 2 2 3 6 6 6 5 Leucine rich repeat LRR_4 PF12799.5 MSTRG.3574.1_2 - 1.3e-21 76.1 30.6 7.5e-05 22.9 0.9 7.5 4 2 4 8 8 8 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 MSTRG.3574.1_2 - 1.5e-20 73.3 0.0 1e-09 38.3 0.0 3.4 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) I-set PF07679.14 MSTRG.3574.1_2 - 1.6e-14 53.6 0.0 4.5e-14 52.1 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.3574.1_2 - 3.2e-11 43.6 0.0 1.5e-10 41.4 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain LRR_9 PF14580.4 MSTRG.3574.1_2 - 1.2e-08 34.5 13.1 0.0047 16.3 0.2 3.4 1 1 1 3 3 3 3 Leucine-rich repeat Ig_2 PF13895.4 MSTRG.3574.1_2 - 2.3e-07 30.9 0.0 5.2e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.31 MSTRG.3574.1_2 - 3e-06 26.8 23.9 20 6.0 0.1 11.6 11 0 0 11 11 11 0 Leucine Rich Repeat ig PF00047.23 MSTRG.3574.1_2 - 9.6e-06 25.6 0.0 4.8e-05 23.3 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain LRRNT PF01462.16 MSTRG.3574.1_2 - 0.0064 16.0 3.8 0.0064 16.0 3.8 2.9 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain V-set PF07686.15 MSTRG.3574.1_2 - 0.042 13.9 0.0 0.74 9.9 0.0 2.5 1 1 0 1 1 1 0 Immunoglobulin V-set domain LRR_6 PF13516.4 MSTRG.3574.1_2 - 0.088 12.8 25.3 4.9 7.3 0.0 8.7 10 0 0 10 10 9 0 Leucine Rich repeat DNase_NucA_NucB PF14040.4 MSTRG.6635.1_2 - 0.064 13.5 0.1 0.13 12.5 0.1 1.5 1 0 0 1 1 1 0 Deoxyribonuclease NucA/NucB TPR_11 PF13414.4 MSTRG.1749.1_2 - 1.2e-10 40.7 3.3 6.2e-08 32.1 0.2 3.1 3 0 0 3 3 3 2 TPR repeat TPR_2 PF07719.15 MSTRG.1749.1_2 - 1.2e-09 37.3 0.2 0.009 15.9 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.1749.1_2 - 2.8e-07 29.9 0.0 0.16 11.7 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.1749.1_2 - 3.2e-07 30.5 0.6 0.096 13.4 0.3 3.7 1 1 2 3 3 3 3 Tetratricopeptide repeat S1 PF00575.21 MSTRG.1749.1_2 - 8.9e-05 22.6 0.2 0.0019 18.4 0.2 2.3 1 1 0 1 1 1 1 S1 RNA binding domain TPR_16 PF13432.4 MSTRG.1749.1_2 - 0.00015 22.3 0.2 0.022 15.3 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.1749.1_2 - 0.00015 21.5 0.0 2.4 8.5 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.4 MSTRG.1749.1_2 - 0.00018 21.4 0.0 0.00056 19.9 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.1749.1_2 - 0.002 18.2 0.5 1.9 8.7 0.3 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.1749.1_2 - 0.0035 17.5 0.1 0.028 14.7 0.2 2.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.1749.1_2 - 0.02 15.3 4.1 1.2 9.5 0.1 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_15 PF13429.4 MSTRG.1749.1_2 - 0.04 13.0 0.2 1 8.4 0.0 2.5 1 1 2 3 3 3 0 Tetratricopeptide repeat DUF737 PF05300.9 MSTRG.15347.2_2 - 6.6e-49 166.9 44.9 8.5e-48 163.2 44.9 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF737) CHCH PF06747.11 MSTRG.15347.2_2 - 0.012 15.6 0.6 0.019 15.0 0.6 1.3 1 0 0 1 1 1 0 CHCH domain bZIP_1 PF00170.19 MSTRG.15347.2_2 - 0.043 13.8 8.1 0.11 12.4 8.1 1.7 1 0 0 1 1 1 0 bZIP transcription factor DUF3292 PF11696.6 MSTRG.15347.2_2 - 0.062 11.5 5.0 0.11 10.7 5.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) ORF6N PF10543.7 MSTRG.15347.2_2 - 0.18 11.9 2.4 5.6 7.1 0.4 2.4 2 0 0 2 2 2 0 ORF6N domain ECH_2 PF16113.3 MSTRG.15347.2_2 - 0.27 10.5 6.6 0.4 10.0 6.6 1.2 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase DUF1690 PF07956.9 MSTRG.15347.2_2 - 0.38 11.0 17.9 0.11 12.8 7.6 2.2 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) FixQ PF05545.9 MSTRG.20004.2_1 - 4.6 7.2 5.3 8.6 6.3 5.3 1.4 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ tRNA-synt_1 PF00133.20 MSTRG.25238.1_1 - 1.1e-33 116.3 0.0 1.3e-33 116.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.9 MSTRG.25238.1_1 - 2.7e-07 29.6 0.0 5.2e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (M) DUF4074 PF13293.4 MSTRG.26070.1_1 - 2e-26 92.0 9.1 2e-26 92.0 9.1 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF4074) MOR2-PAG1_C PF14225.4 MSTRG.7196.3_1 - 2.2e-71 240.6 12.3 2.5e-71 240.4 8.6 2.2 2 0 0 2 2 2 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.4 MSTRG.7196.3_1 - 9.8e-09 33.4 0.9 0.0017 16.0 0.0 2.6 3 0 0 3 3 3 2 Cell morphogenesis central region Tropomyosin PF00261.18 MSTRG.2154.1_1 - 8.1e-101 336.2 85.9 3.7e-97 324.2 61.8 2.0 1 1 1 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.5 MSTRG.2154.1_1 - 1.1e-40 139.0 71.6 5.8e-36 123.6 38.6 3.0 2 1 0 2 2 2 2 Tropomyosin like Laminin_II PF06009.10 MSTRG.2154.1_1 - 7.6e-07 29.1 36.2 7.9e-06 25.8 7.4 4.0 1 1 3 4 4 4 2 Laminin Domain II CLZ PF16526.3 MSTRG.2154.1_1 - 8.9e-07 29.0 46.8 8.2e-05 22.7 11.0 4.9 2 2 2 5 5 5 4 C-terminal leucine zipper domain of cyclic nucleotide-gated channels IncA PF04156.12 MSTRG.2154.1_1 - 0.00056 19.6 59.5 0.0049 16.5 22.6 3.0 1 1 2 3 3 3 1 IncA protein TMF_DNA_bd PF12329.6 MSTRG.2154.1_1 - 0.001 18.9 9.4 0.001 18.9 9.4 6.1 2 2 4 6 6 5 2 TATA element modulatory factor 1 DNA binding DUF745 PF05335.11 MSTRG.2154.1_1 - 0.0028 17.3 45.6 0.13 11.9 12.2 3.2 1 1 2 3 3 3 3 Protein of unknown function (DUF745) AAA_13 PF13166.4 MSTRG.2154.1_1 - 0.025 13.1 47.0 0.38 9.2 13.4 2.1 1 1 1 2 2 2 0 AAA domain SlyX PF04102.10 MSTRG.2154.1_1 - 0.054 14.0 0.6 0.054 14.0 0.6 5.3 1 1 5 6 6 6 0 SlyX DUF1664 PF07889.10 MSTRG.2154.1_1 - 0.068 13.0 28.9 0.12 12.3 4.8 3.8 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) Laminin_I PF06008.12 MSTRG.2154.1_1 - 0.094 12.3 53.5 0.21 11.1 16.2 3.3 1 1 2 3 3 3 0 Laminin Domain I ERM PF00769.17 MSTRG.2154.1_1 - 0.11 12.1 70.9 0.35 10.5 25.7 2.8 1 1 1 2 2 2 0 Ezrin/radixin/moesin family CENP-F_leu_zip PF10473.7 MSTRG.2154.1_1 - 0.12 12.3 63.5 0.035 14.0 32.2 2.3 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF16 PF01519.14 MSTRG.2154.1_1 - 0.32 11.4 37.7 0.56 10.6 0.4 4.2 1 1 3 4 4 4 0 Protein of unknown function DUF16 Reo_sigmaC PF04582.10 MSTRG.2154.1_1 - 0.39 9.9 9.4 0.36 10.0 1.2 2.2 2 0 0 2 2 2 0 Reovirus sigma C capsid protein MscS_porin PF12795.5 MSTRG.2154.1_1 - 0.43 9.9 48.6 9.7 5.5 19.5 2.8 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Alanine_zipper PF11839.6 MSTRG.2154.1_1 - 0.44 10.7 45.4 0.31 11.2 3.4 4.8 1 1 1 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein Golgin_A5 PF09787.7 MSTRG.2154.1_1 - 0.48 9.7 53.1 0.62 9.3 21.3 2.4 1 1 2 3 3 3 0 Golgin subfamily A member 5 XhlA PF10779.7 MSTRG.2154.1_1 - 0.56 10.3 55.5 0.054 13.6 4.0 6.5 1 1 5 6 6 6 0 Haemolysin XhlA ATG16 PF08614.9 MSTRG.2154.1_1 - 0.59 10.2 61.0 0.37 10.8 17.2 3.3 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) ADIP PF11559.6 MSTRG.2154.1_1 - 1.4 8.9 49.3 3.3 7.7 13.9 4.1 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding GAS PF13851.4 MSTRG.2154.1_1 - 2.3 7.4 60.3 0.18 11.0 16.5 3.0 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding MAD PF05557.11 MSTRG.2154.1_1 - 2.7 6.1 57.4 4.7 5.3 20.8 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein Lebercilin PF15619.4 MSTRG.2154.1_1 - 3.5 7.1 62.5 1.9 8.0 30.0 2.8 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease HOOK PF05622.10 MSTRG.2154.1_1 - 4.8 5.1 57.6 0.02 12.9 16.8 2.1 1 1 1 2 2 2 0 HOOK protein Exonuc_VII_L PF02601.13 MSTRG.2154.1_1 - 5.7 6.3 35.6 20 4.5 14.7 2.2 1 1 1 2 2 2 0 Exonuclease VII, large subunit FH2 PF02181.21 MSTRG.2154.1_1 - 7.1 5.5 36.4 0.62 9.0 7.5 3.1 1 1 2 3 3 3 0 Formin Homology 2 Domain APG6 PF04111.10 MSTRG.2154.1_1 - 7.2 5.8 64.5 0.28 10.4 23.0 3.1 1 1 2 3 3 3 0 Autophagy protein Apg6 DASH_Hsk3 PF08227.9 MSTRG.2154.1_1 - 7.4 6.9 6.7 28 5.0 0.1 3.3 4 0 0 4 4 2 0 DASH complex subunit Hsk3 like Pkinase PF00069.23 MSTRG.1787.1_2 - 0.00014 21.2 0.0 0.00024 20.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Vps39_2 PF10367.7 MSTRG.8845.5_1 - 1.2e-31 109.3 4.7 1.8e-31 108.7 4.7 1.3 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 SOAR PF16533.3 MSTRG.29302.1_2 - 4.6e-12 45.6 0.1 4.6e-12 45.6 0.1 2.7 2 1 0 2 2 2 1 STIM1 Orai1-activating region Retrotrans_gag PF03732.15 MSTRG.29302.1_2 - 0.31 11.2 5.3 2.2 8.5 0.3 2.3 1 1 1 2 2 2 0 Retrotransposon gag protein Carn_acyltransf PF00755.18 MSTRG.22115.3_2 - 5.1e-195 649.3 0.0 6e-195 649.1 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase CPT_N PF16484.3 MSTRG.22115.3_2 - 1.9e-27 94.9 0.0 3.8e-27 93.9 0.0 1.6 1 0 0 1 1 1 1 Carnitine O-palmitoyltransferase N-terminus HMG_box PF00505.17 MSTRG.11942.1_1 - 2.4e-27 95.0 3.0 3.7e-27 94.4 3.0 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 MSTRG.11942.1_1 - 6.9e-11 42.5 2.6 1.1e-10 41.8 2.6 1.3 1 0 0 1 1 1 1 HMG-box domain SOXp PF12336.6 MSTRG.11942.1_1 - 0.093 13.7 12.6 0.037 15.0 6.8 3.0 2 2 0 2 2 2 0 SOX transcription factor FG-GAP PF01839.21 MSTRG.9584.1_1 - 3.8e-18 65.2 2.3 3.2e-12 46.2 0.0 3.2 3 0 0 3 3 3 3 FG-GAP repeat VCBS PF13517.4 MSTRG.9584.1_1 - 1.6e-10 41.2 0.2 1.8e-05 25.1 0.4 2.1 2 0 0 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.4 MSTRG.9584.1_1 - 0.0067 16.5 0.3 0.21 11.7 0.1 3.0 3 1 0 3 3 3 1 FG-GAP repeat K1 PF02960.12 MSTRG.9584.1_1 - 0.068 13.2 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 K1 glycoprotein Vert_HS_TF PF06546.9 MSTRG.25724.6_2 - 1.6e-30 106.5 6.5 3.8e-29 102.0 6.5 2.3 1 1 0 1 1 1 1 Vertebrate heat shock transcription factor HSF_DNA-bind PF00447.15 MSTRG.25724.6_2 - 8.7e-25 87.0 1.3 1.9e-24 85.9 1.3 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding ZapB PF06005.10 MSTRG.25724.6_2 - 0.025 14.9 1.9 0.07 13.5 1.9 1.6 1 0 0 1 1 1 0 Cell division protein ZapB CENP-H PF05837.10 MSTRG.25724.6_2 - 0.26 11.6 5.0 0.09 13.1 2.0 1.7 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Kinesin PF00225.21 MSTRG.5692.1_3 - 5.9e-94 314.6 0.5 1.1e-93 313.7 0.5 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 MSTRG.5692.1_3 - 1.5e-14 54.1 0.8 5.8e-14 52.2 0.1 2.3 2 0 0 2 2 2 1 Microtubule binding FAD_binding_5 PF00941.19 MSTRG.26765.2_3 - 6.1e-52 175.7 0.0 9.8e-52 175.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase CO_deh_flav_C PF03450.15 MSTRG.26765.2_3 - 2.8e-33 114.0 0.0 5.6e-33 113.1 0.0 1.6 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.18 MSTRG.26765.2_3 - 1.1e-32 111.6 0.1 2.8e-32 110.4 0.1 1.7 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.25 MSTRG.26765.2_3 - 8.9e-09 35.1 2.3 1.3e-08 34.6 0.1 2.5 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Ald_Xan_dh_C PF01315.20 MSTRG.26765.2_3 - 5.9e-08 32.9 0.0 1.2e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain MNHE PF01899.14 MSTRG.26765.2_3 - 0.0092 15.6 0.0 0.024 14.3 0.0 1.6 2 0 0 2 2 2 1 Na+/H+ ion antiporter subunit DHR-2 PF06920.11 MSTRG.6620.1_3 - 4.7e-204 678.8 10.7 4.7e-204 678.8 10.7 2.3 2 0 0 2 2 2 2 Dock homology region 2 DOCK-C2 PF14429.4 MSTRG.6620.1_3 - 6.7e-55 185.8 0.2 2.3e-54 184.0 0.2 2.0 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins RhoGAP PF00620.25 MSTRG.492.1_1 - 6.3e-42 142.8 0.0 1.3e-41 141.8 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.20 MSTRG.492.1_1 - 2e-06 27.5 5.1 4.4e-06 26.3 5.1 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Ank_2 PF12796.5 MSTRG.29775.1_2 - 6.4e-21 74.6 3.9 1.6e-14 54.1 0.4 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.29775.1_2 - 3.7e-16 59.1 4.7 3.6e-05 24.1 0.1 4.1 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.4 MSTRG.29775.1_2 - 5.9e-15 55.0 6.7 4.4e-07 30.0 0.6 4.1 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.29775.1_2 - 9.3e-15 53.1 2.8 0.032 14.6 0.1 4.4 4 0 0 4 4 4 4 Ankyrin repeat Ank PF00023.28 MSTRG.29775.1_2 - 2e-12 46.8 10.9 0.035 14.4 0.4 4.6 3 1 1 4 4 4 4 Ankyrin repeat zf-C3HC4_5 PF17121.3 MSTRG.12697.1_2 - 0.18 11.6 2.8 0.27 11.0 0.2 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF3429 PF11911.6 MSTRG.12697.1_3 - 3.5e-38 130.9 10.8 4.6e-38 130.6 10.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) NfeD PF01957.16 MSTRG.12697.1_3 - 1.5 9.1 3.4 28 4.9 0.2 2.2 2 0 0 2 2 2 0 NfeD-like C-terminal, partner-binding Cpn60_TCP1 PF00118.22 MSTRG.26534.2_1 - 1.2e-87 294.5 14.3 2.1e-87 293.7 14.3 1.4 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Pkinase_Tyr PF07714.15 MSTRG.2825.4_3 - 4.8e-91 304.5 0.0 6e-91 304.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.2825.4_3 - 1.1e-43 149.4 0.0 1.5e-43 149.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Ibs_toxin PF13956.4 MSTRG.15431.1_2 - 0.084 12.8 0.4 0.15 12.0 0.4 1.4 1 0 0 1 1 1 0 Toxin Ibs, type I toxin-antitoxin system RhoGAP PF00620.25 MSTRG.27453.1_3 - 1.5e-32 112.4 0.4 2.7e-32 111.6 0.4 1.4 1 0 0 1 1 1 1 RhoGAP domain Prefoldin PF02996.15 MSTRG.14083.1_1 - 1.1e-26 93.0 4.0 1.5e-26 92.5 4.0 1.2 1 0 0 1 1 1 1 Prefoldin subunit Uds1 PF15456.4 MSTRG.14083.1_1 - 0.014 15.4 1.5 4.6 7.3 1.3 2.1 2 0 0 2 2 2 0 Up-regulated During Septation ING PF12998.5 MSTRG.14083.1_1 - 0.06 13.8 5.0 0.16 12.4 5.0 1.7 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding RNase_HII PF01351.16 MSTRG.14083.1_1 - 0.077 12.7 3.1 2.2 7.9 1.0 2.1 1 1 1 2 2 2 0 Ribonuclease HII DUF5082 PF16888.3 MSTRG.14083.1_1 - 0.12 12.6 5.1 0.71 10.1 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) DUF2508 PF10704.7 MSTRG.14083.1_1 - 0.17 11.9 3.6 5 7.2 1.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) TRAF_BIRC3_bd PF16673.3 MSTRG.14083.1_1 - 0.33 10.6 2.6 0.67 9.7 0.8 2.0 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain Collagen PF01391.16 MSTRG.24488.4_2 - 5e-173 560.9 855.8 1.3e-09 37.6 28.2 28.2 5 5 21 26 26 26 25 Collagen triple helix repeat (20 copies) C4 PF01413.17 MSTRG.24488.4_2 - 4.8e-82 271.5 2.9 1.3e-43 147.7 0.5 2.3 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen BAH PF01426.16 MSTRG.830.1_2 - 8.7e-13 48.1 0.0 1.5e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 BAH domain SH3_1 PF00018.26 MSTRG.13197.1_1 - 8.9e-07 28.3 0.2 1.4e-06 27.6 0.2 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.13197.1_1 - 0.00058 19.4 0.1 0.0012 18.4 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 MSTRG.13197.1_1 - 0.0027 17.4 0.0 0.0042 16.8 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain VHS PF00790.17 MSTRG.24131.2_3 - 1.1e-46 158.0 0.2 2.8e-46 156.7 0.2 1.7 1 0 0 1 1 1 1 VHS domain Hrs_helical PF12210.6 MSTRG.24131.2_3 - 1.4e-37 128.0 3.7 1.4e-37 128.0 3.7 2.6 2 0 0 2 2 2 1 Hepatocyte growth factor-regulated tyrosine kinase substrate FYVE PF01363.19 MSTRG.24131.2_3 - 5.4e-18 64.8 9.6 1.8e-17 63.1 9.6 1.9 1 0 0 1 1 1 1 FYVE zinc finger DUF3361 PF11841.6 MSTRG.24131.2_3 - 0.0037 17.1 0.1 0.011 15.6 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) FYVE_2 PF02318.14 MSTRG.24131.2_3 - 0.0081 16.2 3.5 0.0081 16.2 3.5 2.8 2 1 0 2 2 2 1 FYVE-type zinc finger UIM PF02809.18 MSTRG.24131.2_3 - 0.038 13.8 6.7 0.1 12.5 6.7 1.8 1 0 0 1 1 1 0 Ubiquitin interaction motif Cnd1 PF12717.5 MSTRG.24131.2_3 - 0.62 9.9 5.5 0.2 11.5 0.1 2.2 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 DUF4407 PF14362.4 MSTRG.24131.2_3 - 5.2 6.2 11.8 9.3 5.4 11.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UCH PF00443.27 MSTRG.24307.1_3 - 2.5e-53 181.0 0.2 4.7e-53 180.2 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.17 MSTRG.24307.1_3 - 9.9e-21 73.7 8.1 9.9e-21 73.7 8.1 3.4 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.4 MSTRG.24307.1_3 - 1e-15 58.0 2.3 2.9e-15 56.5 0.0 2.4 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Pol_alpha_B_N PF08418.8 MSTRG.24307.1_3 - 0.082 12.7 6.0 0.16 11.8 6.0 1.4 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal ABC_tran PF00005.25 MSTRG.20767.1_2 - 7e-76 253.2 1.6 4e-37 127.6 0.1 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.21 MSTRG.20767.1_2 - 2.4e-69 233.9 10.3 3.7e-69 233.3 10.3 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.17 MSTRG.20767.1_2 - 5.3e-13 48.8 6.9 6.7e-07 28.8 1.2 3.7 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.10 MSTRG.20767.1_2 - 3e-10 39.6 0.2 0.00029 20.1 0.0 3.3 3 0 0 3 3 3 2 Zeta toxin AAA_22 PF13401.4 MSTRG.20767.1_2 - 4.2e-10 39.9 1.1 0.00055 20.1 0.1 3.1 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.4 MSTRG.20767.1_2 - 7.9e-10 39.2 1.1 0.00094 19.5 0.0 2.9 2 1 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.7 MSTRG.20767.1_2 - 2e-09 36.6 0.5 7.1e-05 21.6 0.1 2.8 3 0 0 3 3 3 2 Predicted ATPase of the ABC class DUF258 PF03193.14 MSTRG.20767.1_2 - 4.9e-08 32.9 0.4 0.01 15.6 0.0 2.9 3 0 0 3 3 3 2 Protein of unknown function, DUF258 G-alpha PF00503.18 MSTRG.20767.1_2 - 2.7e-07 29.9 0.2 0.011 14.8 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit AAA_15 PF13175.4 MSTRG.20767.1_2 - 7.8e-07 28.9 0.0 0.026 14.0 0.1 2.5 2 1 0 2 2 2 2 AAA ATPase domain Rad17 PF03215.13 MSTRG.20767.1_2 - 3.3e-06 26.2 0.1 0.025 13.4 0.0 2.3 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_28 PF13521.4 MSTRG.20767.1_2 - 3.8e-06 27.1 0.5 1 9.5 0.1 4.6 4 1 0 4 4 4 2 AAA domain AAA_30 PF13604.4 MSTRG.20767.1_2 - 5e-06 26.2 2.4 0.041 13.5 0.4 3.4 2 2 0 2 2 2 2 AAA domain PRK PF00485.16 MSTRG.20767.1_2 - 5.7e-06 26.1 0.1 0.014 15.0 0.0 2.4 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family AAA_21 PF13304.4 MSTRG.20767.1_2 - 1.5e-05 24.8 0.0 2.1 7.9 0.0 4.0 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 MSTRG.20767.1_2 - 1.6e-05 24.4 2.2 0.098 12.3 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_5 PF07728.12 MSTRG.20767.1_2 - 2e-05 24.5 0.1 0.17 11.8 0.0 3.4 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA PF00004.27 MSTRG.20767.1_2 - 3.4e-05 24.1 4.1 0.26 11.6 0.1 4.2 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATP-synt_ab PF00006.23 MSTRG.20767.1_2 - 0.00025 20.6 0.0 0.25 10.8 0.0 2.5 2 1 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain AAA_18 PF13238.4 MSTRG.20767.1_2 - 0.00041 20.7 0.0 0.78 10.1 0.0 3.0 3 0 0 3 3 3 1 AAA domain SRP54 PF00448.20 MSTRG.20767.1_2 - 0.00044 19.8 0.1 0.86 9.1 0.0 3.1 3 0 0 3 3 3 2 SRP54-type protein, GTPase domain SbcCD_C PF13558.4 MSTRG.20767.1_2 - 0.00055 20.0 5.0 1.1 9.4 0.5 3.8 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit DUF815 PF05673.11 MSTRG.20767.1_2 - 0.00067 18.8 0.1 0.49 9.4 0.0 2.6 2 1 0 2 2 2 2 Protein of unknown function (DUF815) AAA_24 PF13479.4 MSTRG.20767.1_2 - 0.00078 19.1 0.0 0.32 10.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.20 MSTRG.20767.1_2 - 0.0024 18.1 0.1 3.8 7.8 0.0 2.8 2 0 0 2 2 2 1 RNA helicase DUF87 PF01935.15 MSTRG.20767.1_2 - 0.0047 16.9 3.3 1 9.2 0.1 2.9 3 0 0 3 3 3 2 Domain of unknown function DUF87 AIG1 PF04548.14 MSTRG.20767.1_2 - 0.0072 15.5 0.8 1.3 8.1 0.0 2.4 2 0 0 2 2 2 1 AIG1 family Dak1 PF02733.15 MSTRG.20767.1_2 - 0.0087 14.8 0.3 0.015 14.0 0.3 1.3 1 0 0 1 1 1 1 Dak1 domain AAA_25 PF13481.4 MSTRG.20767.1_2 - 0.016 14.7 0.3 6.6 6.1 0.0 3.1 4 0 0 4 4 3 0 AAA domain AAA_33 PF13671.4 MSTRG.20767.1_2 - 0.022 14.8 0.5 13 5.8 0.6 2.8 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.15 MSTRG.20767.1_2 - 0.023 14.3 1.0 29 4.2 0.0 3.8 4 0 0 4 4 4 0 IstB-like ATP binding protein Viral_helicase1 PF01443.16 MSTRG.20767.1_2 - 0.027 14.1 0.1 9.2 5.8 0.0 2.7 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.19 MSTRG.20767.1_2 - 0.028 13.7 0.0 4.9 6.3 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI APS_kinase PF01583.18 MSTRG.20767.1_2 - 0.042 13.6 0.3 4.6 7.0 0.0 2.9 3 0 0 3 3 2 0 Adenylylsulphate kinase MMR_HSR1 PF01926.21 MSTRG.20767.1_2 - 0.051 13.5 0.0 11 6.0 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase tRNA_lig_kinase PF08303.9 MSTRG.20767.1_2 - 0.052 13.5 0.1 10 6.0 0.0 2.5 2 0 0 2 2 2 0 tRNA ligase kinase domain AAA_10 PF12846.5 MSTRG.20767.1_2 - 0.072 11.9 0.2 2.2 7.0 0.0 2.3 2 0 0 2 2 2 0 AAA-like domain NACHT PF05729.10 MSTRG.20767.1_2 - 0.074 12.8 0.1 13 5.5 0.0 2.6 2 0 0 2 2 2 0 NACHT domain AAA_23 PF13476.4 MSTRG.20767.1_2 - 0.16 12.4 1.2 35 4.7 0.0 3.2 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.4 MSTRG.20767.1_2 - 0.36 11.0 2.9 22 5.2 0.3 3.1 2 2 0 2 2 2 0 AAA domain DEAD PF00270.27 MSTRG.20304.1_1 - 5.5e-33 114.1 0.0 1.1e-32 113.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.20304.1_1 - 1.5e-25 89.6 0.0 5.7e-25 87.7 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.20304.1_1 - 2.2e-06 27.6 0.0 7.5e-06 25.9 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.4 MSTRG.20304.1_1 - 0.074 12.6 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.4 MSTRG.20304.1_1 - 0.15 12.3 0.0 0.29 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain CMS1 PF14617.4 MSTRG.20304.1_1 - 0.29 10.3 0.0 0.29 10.3 0.0 2.0 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit TMEM237 PF15383.4 MSTRG.20304.1_1 - 1.1 8.1 2.9 1.2 8.1 0.0 2.0 2 0 0 2 2 2 0 Transmembrane protein 237 SLAIN PF15301.4 MSTRG.7508.2_1 - 3.6e-147 491.0 29.9 5.4e-147 490.4 29.9 1.3 1 0 0 1 1 1 1 SLAIN motif-containing family TSC22 PF01166.16 MSTRG.7508.2_1 - 2.7 8.3 6.9 7.1 6.9 0.4 3.0 3 0 0 3 3 3 0 TSC-22/dip/bun family Ion_trans PF00520.29 MSTRG.2511.1_1 - 3.8e-37 127.7 4.5 5e-37 127.3 4.5 1.1 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.27 MSTRG.2511.1_1 - 1.8e-13 50.1 0.0 4.2e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.14 MSTRG.2511.1_1 - 2.1e-11 43.5 0.1 2.1e-11 43.5 0.1 2.1 2 0 0 2 2 2 1 Ion channel RGS PF00615.17 MSTRG.10299.1_3 - 2.6e-31 108.2 1.0 4.6e-31 107.4 1.0 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain RBD PF02196.13 MSTRG.10299.1_3 - 4.4e-28 97.0 0.0 1e-19 70.3 0.0 2.4 2 0 0 2 2 2 2 Raf-like Ras-binding domain GoLoco PF02188.15 MSTRG.10299.1_3 - 8.6e-07 28.2 2.2 1.5e-06 27.4 2.2 1.4 1 0 0 1 1 1 1 GoLoco motif TUG-UBL1 PF11470.6 MSTRG.10299.1_3 - 0.0036 17.4 0.2 0.24 11.6 0.1 2.8 3 0 0 3 3 3 1 TUG ubiquitin-like domain Aconitase PF00330.18 MSTRG.7941.1_3 - 5.3e-156 520.1 0.0 6.6e-156 519.7 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.17 MSTRG.7941.1_3 - 1.3e-45 154.8 0.0 2.4e-45 153.9 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.11 MSTRG.7941.1_3 - 0.15 10.6 0.0 0.27 9.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF521) GYF PF02213.14 MSTRG.2516.2_1 - 1.9e-18 65.8 5.1 4.8e-18 64.5 5.1 1.7 1 0 0 1 1 1 1 GYF domain Ribul_P_3_epim PF00834.17 MSTRG.22963.3_3 - 3.7e-66 222.2 0.0 4.4e-66 221.9 0.0 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.17 MSTRG.22963.3_3 - 0.079 12.6 0.0 0.3 10.7 0.0 1.8 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain Peptidase_M28 PF04389.15 MSTRG.8429.1_2 - 7.8e-11 41.9 0.0 1.3e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Nicastrin PF05450.13 MSTRG.8429.1_2 - 2.2e-06 27.2 0.0 4.4e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Nicastrin ASL_C PF08328.9 MSTRG.8429.1_2 - 0.14 12.1 0.0 0.31 11.0 0.0 1.5 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminal CCDC23 PF15674.3 MSTRG.13020.1_3 - 3.7e-29 100.4 10.9 5.6e-29 99.8 10.2 1.6 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 23 Peptidase_M1 PF01433.18 MSTRG.24229.2_2 - 0.0031 16.7 0.0 0.0041 16.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M1 Clathrin PF00637.18 MSTRG.11193.2_1 - 2.5e-05 24.0 0.1 4.7e-05 23.2 0.1 1.3 1 0 0 1 1 1 1 Region in Clathrin and VPS TSGP1 PF07771.9 MSTRG.11193.2_1 - 0.15 12.0 0.1 0.29 11.2 0.1 1.3 1 0 0 1 1 1 0 Tick salivary peptide group 1 VPS11_C PF12451.6 MSTRG.11193.2_2 - 1.6e-16 60.1 1.0 3.7e-16 58.9 1.0 1.7 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal Clathrin PF00637.18 MSTRG.11193.2_2 - 2e-08 34.1 5.6 2.6e-05 24.0 2.0 2.3 2 0 0 2 2 2 2 Region in Clathrin and VPS zf-C3HC4_2 PF13923.4 MSTRG.11193.2_2 - 9.9e-07 28.4 9.9 2.4e-06 27.2 9.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3H2C3 PF17122.3 MSTRG.11193.2_2 - 1.1e-05 25.2 10.6 2e-05 24.4 10.6 1.5 1 0 0 1 1 1 1 Zinc-finger zf-rbx1 PF12678.5 MSTRG.11193.2_2 - 1.9e-05 24.7 7.5 5.7e-05 23.2 7.5 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.4 MSTRG.11193.2_2 - 6.1e-05 23.1 9.2 6.1e-05 23.1 9.2 2.1 2 0 0 2 2 1 1 Ring finger domain zf-ANAPC11 PF12861.5 MSTRG.11193.2_2 - 0.0024 17.7 3.1 0.0056 16.6 2.2 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.23 MSTRG.11193.2_2 - 0.0071 16.1 10.1 0.0071 16.1 10.1 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 MSTRG.11193.2_2 - 0.0085 15.9 9.4 0.02 14.7 9.4 1.6 1 0 0 1 1 1 1 zinc-RING finger domain PI3K_P85_iSH2 PF16454.3 MSTRG.11193.2_2 - 0.015 14.7 0.7 0.031 13.7 0.7 1.4 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain ADIP PF11559.6 MSTRG.11193.2_2 - 0.022 14.7 1.6 0.045 13.7 1.6 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding zf-C3HC4_3 PF13920.4 MSTRG.11193.2_2 - 0.15 11.8 6.0 0.39 10.5 6.0 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DivIC PF04977.13 MSTRG.11193.2_2 - 0.42 10.3 2.6 0.92 9.2 2.6 1.5 1 0 0 1 1 1 0 Septum formation initiator zf-RING_UBOX PF13445.4 MSTRG.11193.2_2 - 0.53 10.2 10.1 1.5 8.8 10.1 1.8 1 0 0 1 1 1 0 RING-type zinc-finger zf-Nse PF11789.6 MSTRG.11193.2_2 - 0.66 9.7 6.1 1.5 8.6 6.1 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Rav1p_C PF12234.6 MSTRG.17447.1_2 - 3.2e-80 270.2 0.0 2.6e-70 237.5 0.1 2.3 2 0 0 2 2 2 2 RAVE protein 1 C terminal WD40 PF00400.30 MSTRG.17447.1_2 - 0.00026 21.6 17.8 0.45 11.3 0.1 6.2 7 0 0 7 7 7 3 WD domain, G-beta repeat PRK PF00485.16 MSTRG.8737.3_1 - 1.3e-41 142.4 0.9 1.8e-41 141.9 0.9 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family Vitellogenin_N PF01347.20 MSTRG.13556.6_3 - 9.1e-161 536.2 0.0 9.1e-161 536.2 0.0 2.6 2 1 0 2 2 2 1 Lipoprotein amino terminal region DUF1943 PF09172.9 MSTRG.13556.6_3 - 6.4e-60 202.9 0.0 1.5e-59 201.7 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1943) DUF1944 PF09175.8 MSTRG.13556.6_3 - 1.5e-45 154.9 0.0 3.5e-45 153.7 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1944) VWD PF00094.23 MSTRG.13556.6_3 - 7.2e-21 75.0 0.1 2e-20 73.6 0.1 1.8 1 0 0 1 1 1 1 von Willebrand factor type D domain Tetraspannin PF00335.18 MSTRG.1048.2_3 - 5.3e-56 189.6 6.9 5.3e-56 189.6 6.9 1.7 2 0 0 2 2 2 1 Tetraspanin family DUF3883 PF13020.4 MSTRG.1048.2_3 - 0.061 13.2 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3883) PDZ PF00595.22 MSTRG.4124.1_2 - 2.4e-27 94.9 3.5 1.4e-12 47.6 1.2 2.6 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.4124.1_2 - 9.6e-11 41.7 0.7 0.0002 21.5 0.0 3.0 3 0 0 3 3 3 2 PDZ domain zf-4CXXC_R1 PF10497.7 MSTRG.27006.1_3 - 6.3e-37 125.7 11.5 1.4e-36 124.6 11.5 1.6 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Peptidase_S41_N PF11918.6 MSTRG.27006.1_3 - 0.031 14.4 0.1 0.089 12.9 0.1 1.8 1 0 0 1 1 1 0 N-terminal domain of Peptidase_S41 in eukaryotic IRBP Spore_GerAC PF05504.9 MSTRG.27006.1_3 - 0.094 12.9 0.2 0.17 12.0 0.2 1.4 1 0 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal EF-hand_6 PF13405.4 MSTRG.12548.1_1 - 2.4e-08 33.2 0.6 0.0022 17.6 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.4 MSTRG.12548.1_1 - 4e-08 32.3 1.4 6.9e-06 25.2 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 MSTRG.12548.1_1 - 1.5e-07 31.7 0.3 2.5e-07 30.9 0.3 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 MSTRG.12548.1_1 - 5.3e-07 28.6 0.9 0.00025 20.2 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.4 MSTRG.12548.1_1 - 1.9e-05 24.2 0.6 3.9e-05 23.2 0.6 1.5 1 0 0 1 1 1 1 EF-hand domain pair S_100 PF01023.17 MSTRG.12548.1_1 - 0.00051 19.6 0.0 0.0011 18.5 0.0 1.4 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_4 PF12763.5 MSTRG.12548.1_1 - 0.0035 17.1 0.3 0.0054 16.5 0.3 1.2 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 MSTRG.12548.1_1 - 0.0044 17.2 0.4 0.0062 16.7 0.4 1.2 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.4 MSTRG.12548.1_1 - 0.37 10.5 2.4 0.41 10.4 0.2 2.1 3 0 0 3 3 3 0 EF hand DUF3314 PF11771.6 MSTRG.27803.1_1 - 7.9e-10 39.0 0.0 9.8e-10 38.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3314) Vma12 PF11712.6 MSTRG.10572.1_2 - 0.045 13.7 0.1 0.078 12.9 0.1 1.3 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase eIF-5_eIF-2B PF01873.15 MSTRG.1263.1_1 - 3.2e-41 139.7 0.4 1.3e-40 137.8 0.1 2.1 2 0 0 2 2 2 1 Domain found in IF2B/IF5 W2 PF02020.16 MSTRG.1263.1_1 - 2.4e-21 75.5 1.7 8.5e-21 73.8 1.7 2.0 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon MFS_1 PF07690.14 MSTRG.15407.2_2 - 2.8e-06 26.4 0.0 4.2e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4407 PF14362.4 MSTRG.19110.1_2 - 0.29 10.3 13.6 0.011 15.0 3.1 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) IncA PF04156.12 MSTRG.19110.1_2 - 0.72 9.5 23.5 0.31 10.7 7.6 2.4 2 0 0 2 2 2 0 IncA protein Borrelia_P83 PF05262.9 MSTRG.17968.2_1 - 1.9 6.8 8.6 2.8 6.2 8.6 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DRY_EERY PF09750.7 MSTRG.17968.2_2 - 6.3e-42 142.9 0.0 6.3e-42 142.9 0.0 1.8 2 0 0 2 2 2 1 Alternative splicing regulator SPX PF03105.17 MSTRG.8162.2_1 - 0.023 14.5 10.0 0.033 14.0 10.0 1.2 1 0 0 1 1 1 0 SPX domain PRY PF13765.4 MSTRG.8162.2_2 - 1.6e-22 78.8 0.2 3.5e-22 77.6 0.2 1.6 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 MSTRG.8162.2_2 - 3.3e-16 59.4 0.0 8.3e-16 58.1 0.0 1.6 1 0 0 1 1 1 1 SPRY domain DUF805 PF05656.12 MSTRG.8162.2_3 - 6.2 7.1 9.0 12 6.2 9.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF805) DUF2244 PF10003.7 MSTRG.8162.2_3 - 8.5 5.9 10.1 15 5.2 10.1 1.3 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) Pkinase PF00069.23 MSTRG.14326.1_2 - 9.7e-27 93.8 0.0 1.3e-26 93.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.14326.1_2 - 7.6e-14 51.5 0.0 1e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase adh_short PF00106.23 MSTRG.1946.1_1 - 3.9e-37 127.5 0.6 7.9e-37 126.5 0.6 1.5 1 0 0 1 1 1 1 short chain dehydrogenase MaoC_dehydratas PF01575.17 MSTRG.1946.1_1 - 3.7e-34 116.8 0.0 6.7e-34 116.0 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain adh_short_C2 PF13561.4 MSTRG.1946.1_1 - 3.2e-32 111.8 1.0 7.2e-32 110.7 1.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase SCP2 PF02036.15 MSTRG.1946.1_1 - 5.8e-25 87.6 0.1 1.2e-24 86.6 0.1 1.6 1 0 0 1 1 1 1 SCP-2 sterol transfer family KR PF08659.8 MSTRG.1946.1_1 - 1.3e-13 51.1 1.0 2.2e-13 50.4 1.0 1.3 1 0 0 1 1 1 1 KR domain MaoC_dehydrat_N PF13452.4 MSTRG.1946.1_1 - 6.4e-09 35.9 0.0 1.1e-07 31.9 0.0 2.4 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase Alkyl_sulf_C PF14864.4 MSTRG.1946.1_1 - 2.2e-05 24.6 0.0 4.5e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal Choline_transpo PF04515.10 MSTRG.23752.1_1 - 1.5e-103 346.3 31.8 1.5e-103 346.3 31.8 3.2 4 0 0 4 4 4 2 Plasma-membrane choline transporter EB1 PF03271.15 MSTRG.19964.2_3 - 4.4e-18 65.1 0.1 9e-18 64.1 0.1 1.6 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.29 MSTRG.19964.2_3 - 6.4e-11 42.3 0.2 9.5e-11 41.7 0.2 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain MHC_I PF00129.16 MSTRG.6198.1_1 - 1.5e-32 112.5 0.3 2e-32 112.1 0.3 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 MSTRG.6198.1_1 - 1.4e-09 38.1 0.0 2.8e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain AHSP PF09236.8 MSTRG.6198.1_1 - 0.096 13.0 0.1 3 8.2 0.0 2.4 2 0 0 2 2 2 0 Alpha-haemoglobin stabilising protein MBOAT PF03062.17 MSTRG.29106.1_1 - 0.0011 18.2 0.3 0.0013 18.0 0.3 1.1 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family 2OG-FeII_Oxy_2 PF13532.4 MSTRG.3071.3_1 - 2.4e-25 89.8 0.0 3.2e-25 89.4 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SRF-TF PF00319.16 MSTRG.14773.2_3 - 2.2e-19 68.5 0.1 4.4e-19 67.6 0.1 1.5 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) TFIIF_alpha PF05793.10 MSTRG.18668.1_2 - 1.3e-180 601.3 45.1 1.6e-180 601.1 45.1 1.0 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PMP22_Claudin PF00822.18 MSTRG.27928.1_2 - 4.7e-32 111.0 12.5 6.7e-32 110.5 12.5 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family DUF3852 PF12963.5 MSTRG.27928.1_2 - 0.15 12.3 5.7 0.34 11.1 5.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3852) Glucos_trans_II PF14264.4 MSTRG.27928.1_2 - 0.39 9.9 11.2 0.051 12.8 4.2 2.0 1 1 1 2 2 2 0 Glucosyl transferase GtrII L_HMGIC_fpl PF10242.7 MSTRG.27928.1_2 - 6 6.9 15.0 1.1 9.3 7.8 2.6 2 1 1 3 3 3 0 Lipoma HMGIC fusion partner-like protein Claudin_2 PF13903.4 MSTRG.27928.1_2 - 7.4 6.1 21.2 1 8.9 12.2 2.6 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Acyltransf_C PF16076.3 MSTRG.7706.1_2 - 9.8e-25 86.4 0.0 1.8e-24 85.5 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus Acyltransferase PF01553.19 MSTRG.7706.1_2 - 6.5e-14 51.6 0.0 1.2e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase PRKCSH PF07915.11 MSTRG.7501.2_1 - 0.056 14.3 0.2 0.14 13.0 0.1 1.7 2 0 0 2 2 2 0 Glucosidase II beta subunit-like protein FH2 PF02181.21 MSTRG.7501.2_2 - 1.5e-12 47.3 0.0 1.7e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain VIR_N PF15912.3 MSTRG.7501.2_2 - 0.08 12.5 2.7 0.13 11.8 2.7 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal HCO3_cotransp PF00955.19 MSTRG.2263.2_1 - 7.6e-131 437.3 0.8 1.1e-130 436.8 0.8 1.2 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 MSTRG.2263.2_1 - 7.8e-107 356.9 1.2 7.8e-107 356.9 1.2 2.2 2 0 0 2 2 2 1 Band 3 cytoplasmic domain PTS_EIIA_2 PF00359.20 MSTRG.2263.2_1 - 0.00012 21.9 0.0 0.00059 19.6 0.0 2.0 2 0 0 2 2 2 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 Pox_Ag35 PF03286.12 MSTRG.2263.2_1 - 0.47 10.1 5.3 1.1 8.9 5.3 1.6 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Dynactin_p62 PF05502.11 MSTRG.2263.2_1 - 0.76 8.4 2.7 1.3 7.6 2.7 1.2 1 0 0 1 1 1 0 Dynactin p62 family Ion_trans PF00520.29 MSTRG.24215.1_1 - 2.1e-51 174.4 3.2 2.9e-51 173.9 3.2 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 MSTRG.24215.1_1 - 4.7e-28 97.3 0.0 8.2e-28 96.5 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 MSTRG.24215.1_1 - 3.2e-13 49.3 6.6 3.2e-13 49.3 6.6 2.2 2 0 0 2 2 2 1 Ion channel PKD_channel PF08016.10 MSTRG.24215.1_1 - 0.014 13.9 2.3 0.026 13.1 2.3 1.3 1 0 0 1 1 1 0 Polycystin cation channel Sigma_reg_N PF13800.4 MSTRG.24215.1_1 - 0.39 10.9 1.5 4.3 7.6 0.1 2.8 3 0 0 3 3 3 0 Sigma factor regulator N-terminal Sushi PF00084.18 MSTRG.12100.1_3 - 2e-24 85.8 29.0 3.4e-07 30.6 0.3 5.1 5 0 0 5 5 5 4 Sushi repeat (SCR repeat) Sushi PF00084.18 MSTRG.1763.1_3 - 1.1e-92 304.4 104.4 6.8e-10 39.3 0.9 18.2 17 1 1 18 18 18 16 Sushi repeat (SCR repeat) cEGF PF12662.5 MSTRG.1763.1_3 - 1.3 8.9 17.7 12 5.8 0.1 7.0 6 0 0 6 6 6 0 Complement Clr-like EGF-like Sushi_2 PF09014.8 MSTRG.1763.1_3 - 1.9 8.4 15.2 0.077 12.8 0.4 4.9 5 1 1 6 6 6 0 Beta-2-glycoprotein-1 fifth domain Nepo_coat_N PF03689.13 MSTRG.12375.7_1 - 0.079 12.8 0.4 0.25 11.2 0.0 2.0 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain Zona_pellucida PF00100.21 MSTRG.12375.7_3 - 3.5e-18 66.2 1.0 4.9e-18 65.7 1.0 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain GrpE PF01025.17 MSTRG.1535.1_3 - 5.1e-43 146.5 0.5 6.7e-43 146.1 0.5 1.1 1 0 0 1 1 1 1 GrpE Peptidase_S46 PF10459.7 MSTRG.1535.1_3 - 0.048 12.2 0.6 0.062 11.8 0.6 1.0 1 0 0 1 1 1 0 Peptidase S46 DUF2408 PF10303.7 MSTRG.1535.1_3 - 0.063 13.7 1.5 0.097 13.1 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) DUF3450 PF11932.6 MSTRG.1535.1_3 - 0.52 9.4 6.2 0.76 8.9 6.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Bap31 PF05529.10 MSTRG.1535.1_3 - 0.7 9.3 3.3 1.1 8.7 3.3 1.2 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like CCM2_C PF16545.3 MSTRG.16463.1_1 - 2.2e-46 156.4 0.1 4.2e-46 155.4 0.1 1.5 1 0 0 1 1 1 1 Cerebral cavernous malformation protein, harmonin-homology PID PF00640.21 MSTRG.16463.1_1 - 0.022 14.7 0.0 0.056 13.4 0.0 1.6 2 0 0 2 2 2 0 Phosphotyrosine interaction domain (PTB/PID) DUF1722 PF08349.9 MSTRG.16463.1_1 - 0.032 14.4 0.0 0.073 13.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1722) RRM_1 PF00076.20 MSTRG.4625.1_2 - 1.3e-53 178.6 0.1 1.2e-18 66.5 0.1 3.6 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.4625.1_2 - 7.9e-07 29.0 0.1 0.085 12.9 0.0 3.6 3 0 0 3 3 3 3 RNA recognition motif RRM_5 PF13893.4 MSTRG.4625.1_2 - 0.00048 19.6 0.0 0.057 12.9 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.9 MSTRG.4625.1_2 - 0.00069 19.5 0.0 0.4 10.6 0.0 3.5 3 0 0 3 3 3 1 RNA binding domain Nup35_RRM_2 PF14605.4 MSTRG.4625.1_2 - 0.0035 17.2 0.0 2.1 8.2 0.0 4.1 5 0 0 5 5 5 1 Nup53/35/40-type RNA recognition motif NOP5NT PF08156.11 MSTRG.4625.1_2 - 0.11 12.7 0.5 24 5.2 0.0 3.3 3 0 0 3 3 3 0 NOP5NT (NUC127) domain RabGAP-TBC PF00566.16 MSTRG.1477.2_1 - 1.1e-11 44.7 0.3 1.7e-11 44.0 0.3 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.18 MSTRG.1477.2_2 - 1.6e-31 108.4 0.0 9.5e-16 57.5 0.0 2.3 2 0 0 2 2 2 2 GRAM domain RabGAP-TBC PF00566.16 MSTRG.1477.2_3 - 1.6e-24 86.6 0.0 2.6e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Filamin PF00630.17 MSTRG.12971.5_3 - 5.9e-47 158.6 0.6 7.8e-12 45.8 0.0 4.3 4 0 0 4 4 4 4 Filamin/ABP280 repeat Myco_19_kDa PF05481.10 MSTRG.12971.5_3 - 0.005 16.7 0.4 0.005 16.7 0.4 2.0 2 0 0 2 2 2 1 Mycobacterium 19 kDa lipoprotein antigen Y_Y_Y PF07495.11 MSTRG.12971.5_3 - 0.057 13.2 0.1 7.3 6.5 0.1 2.8 3 0 0 3 3 3 0 Y_Y_Y domain V-set PF07686.15 MSTRG.25201.2_1 - 2.6e-11 43.5 0.2 2.2e-06 27.7 0.0 3.3 2 1 0 3 3 3 2 Immunoglobulin V-set domain ig PF00047.23 MSTRG.25201.2_1 - 1e-09 38.3 4.6 0.0011 18.9 0.5 3.6 3 1 1 4 4 4 2 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.25201.2_1 - 2e-07 31.4 0.7 0.0095 16.4 0.6 3.5 2 1 1 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.25201.2_1 - 1.5e-06 28.4 0.3 0.0068 16.6 0.1 3.8 2 2 1 3 3 3 2 Immunoglobulin domain I-set PF07679.14 MSTRG.25201.2_1 - 2.6e-06 27.3 0.1 0.13 12.2 0.1 3.0 2 1 0 2 2 2 2 Immunoglobulin I-set domain Izumo-Ig PF16706.3 MSTRG.25201.2_1 - 0.0086 16.0 0.0 2.8 7.9 0.0 2.8 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain G0-G1_switch_2 PF15103.4 MSTRG.25201.2_1 - 0.011 16.0 0.0 0.87 9.9 0.0 2.4 2 0 0 2 2 2 0 G0/G1 switch protein 2 V-set_CD47 PF08204.9 MSTRG.25201.2_1 - 0.029 14.2 0.3 1.9 8.4 0.2 2.9 2 1 1 3 3 3 0 CD47 immunoglobulin-like domain Ig_5 PF16681.3 MSTRG.25201.2_1 - 0.058 13.7 0.2 4.4 7.7 0.1 3.3 2 1 1 3 3 3 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.10 MSTRG.25201.2_1 - 0.1 12.6 0.3 0.84 9.6 0.0 2.5 1 1 1 2 2 2 0 CD80-like C2-set immunoglobulin domain Homeobox PF00046.27 MSTRG.20878.1_2 - 2.1e-08 33.7 0.2 2.9e-08 33.3 0.2 1.2 1 0 0 1 1 1 1 Homeobox domain AAA PF00004.27 MSTRG.2828.1_3 - 2.2e-52 176.8 0.0 3e-42 144.1 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 MSTRG.2828.1_3 - 2.3e-07 31.2 11.3 0.0026 18.0 0.0 4.8 2 2 1 4 4 4 2 AAA ATPase domain AAA_22 PF13401.4 MSTRG.2828.1_3 - 3.5e-06 27.2 2.3 0.068 13.3 0.1 3.8 2 2 1 3 3 3 2 AAA domain RNA_helicase PF00910.20 MSTRG.2828.1_3 - 5.7e-06 26.5 0.0 0.11 12.8 0.0 2.4 2 0 0 2 2 2 2 RNA helicase AAA_2 PF07724.12 MSTRG.2828.1_3 - 1.2e-05 25.4 0.0 0.0019 18.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.4 MSTRG.2828.1_3 - 1.6e-05 24.8 0.0 0.095 12.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain NACHT PF05729.10 MSTRG.2828.1_3 - 1.7e-05 24.6 4.4 0.27 11.0 0.1 3.8 3 1 0 3 3 3 2 NACHT domain IstB_IS21 PF01695.15 MSTRG.2828.1_3 - 3.7e-05 23.4 0.0 0.021 14.5 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_33 PF13671.4 MSTRG.2828.1_3 - 4.3e-05 23.6 0.0 0.019 15.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.4 MSTRG.2828.1_3 - 0.00013 21.5 1.5 0.45 9.9 0.1 3.5 3 1 0 3 3 3 1 AAA domain RuvB_N PF05496.10 MSTRG.2828.1_3 - 0.00021 20.5 0.0 0.00046 19.4 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_18 PF13238.4 MSTRG.2828.1_3 - 0.00024 21.5 0.0 0.024 15.0 0.0 2.7 3 0 0 3 3 2 1 AAA domain TIP49 PF06068.11 MSTRG.2828.1_3 - 0.00037 19.4 0.0 0.00071 18.5 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus ABC_tran PF00005.25 MSTRG.2828.1_3 - 0.0014 19.0 0.0 1.8 8.9 0.0 2.9 4 0 0 4 4 2 1 ABC transporter AAA_28 PF13521.4 MSTRG.2828.1_3 - 0.0016 18.6 0.0 0.0098 16.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.12 MSTRG.2828.1_3 - 0.0021 18.0 0.4 0.042 13.7 0.1 2.8 2 2 0 2 2 2 1 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.16 MSTRG.2828.1_3 - 0.0028 17.3 0.0 1.1 8.8 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase TsaE PF02367.15 MSTRG.2828.1_3 - 0.0034 17.2 0.0 0.028 14.3 0.0 2.2 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.11 MSTRG.2828.1_3 - 0.0048 16.0 0.0 2 7.4 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF815) Parvo_NS1 PF01057.15 MSTRG.2828.1_3 - 0.029 13.3 0.0 0.049 12.6 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Mg_chelatase PF01078.19 MSTRG.2828.1_3 - 0.03 13.6 0.2 0.078 12.2 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.4 MSTRG.2828.1_3 - 0.034 14.3 0.1 7.4 6.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.23 MSTRG.2828.1_3 - 0.039 13.5 0.0 0.94 9.0 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Sigma54_activat PF00158.24 MSTRG.2828.1_3 - 0.058 13.0 0.2 0.24 11.0 0.0 2.1 2 1 0 2 2 2 0 Sigma-54 interaction domain Sigma54_activ_2 PF14532.4 MSTRG.2828.1_3 - 0.07 13.1 0.0 2.4 8.1 0.0 2.7 2 0 0 2 2 2 0 Sigma-54 interaction domain ATPase PF06745.11 MSTRG.2828.1_3 - 0.088 12.0 0.0 0.24 10.6 0.0 1.7 1 0 0 1 1 1 0 KaiC Cytidylate_kin2 PF13189.4 MSTRG.2828.1_3 - 0.12 12.4 0.0 0.3 11.1 0.0 1.7 2 0 0 2 2 1 0 Cytidylate kinase-like family AAA_3 PF07726.9 MSTRG.2828.1_3 - 0.14 11.9 0.0 0.3 10.8 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.20 MSTRG.2828.1_3 - 0.14 11.0 0.0 0.8 8.5 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain Bac_DnaA PF00308.16 MSTRG.2828.1_3 - 0.14 11.8 0.0 1.8 8.2 0.0 2.4 2 1 0 2 2 2 0 Bacterial dnaA protein DUF2075 PF09848.7 MSTRG.2828.1_3 - 0.16 11.0 0.0 0.32 10.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DAP3 PF10236.7 MSTRG.2828.1_3 - 0.19 10.8 0.4 13 4.7 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_24 PF13479.4 MSTRG.2828.1_3 - 0.19 11.3 0.1 0.6 9.7 0.1 1.7 2 0 0 2 2 2 0 AAA domain DLH PF01738.16 MSTRG.360.1_1 - 4.1e-43 147.3 0.0 5.1e-43 147.0 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.18 MSTRG.360.1_1 - 4.2e-06 26.5 0.0 0.014 14.9 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 MSTRG.360.1_1 - 0.00011 21.7 0.0 0.00052 19.4 0.0 1.9 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.5 MSTRG.360.1_1 - 0.00016 21.3 0.0 0.00053 19.6 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.14 MSTRG.360.1_1 - 0.002 17.8 0.0 0.0039 16.9 0.0 1.4 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase FSH1 PF03959.11 MSTRG.360.1_1 - 0.0036 16.8 0.0 0.011 15.3 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Hydrolase_4 PF12146.6 MSTRG.360.1_1 - 0.022 13.9 0.0 0.088 11.9 0.0 1.9 1 1 1 2 2 2 0 Serine aminopeptidase, S33 BAAT_C PF08840.9 MSTRG.360.1_1 - 0.1 12.4 0.0 5.6 6.7 0.0 2.1 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal E1-E2_ATPase PF00122.18 MSTRG.24778.1_1 - 7.5e-58 195.3 1.5 7.5e-58 195.3 1.5 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 MSTRG.24778.1_1 - 3.3e-43 147.4 0.4 3.3e-43 147.4 0.4 1.9 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 MSTRG.24778.1_1 - 8.1e-24 83.4 0.1 1.7e-23 82.4 0.1 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 MSTRG.24778.1_1 - 2.5e-18 67.0 0.2 5e-09 36.6 0.0 3.0 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 MSTRG.24778.1_1 - 2.8e-18 65.2 0.0 5.2e-18 64.4 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 MSTRG.24778.1_1 - 9.4e-06 25.4 1.1 0.00089 18.9 0.5 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase MIP-T3 PF10243.7 MSTRG.19306.1_1 - 0.057 12.0 9.3 0.079 11.5 9.3 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 SRF-TF PF00319.16 MSTRG.19306.1_2 - 8.1e-20 69.9 0.1 1.3e-19 69.2 0.1 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) SIR2 PF02146.15 MSTRG.14745.7_1 - 5.6e-09 36.0 0.0 7.4e-09 35.6 0.0 1.1 1 0 0 1 1 1 1 Sir2 family SIR2 PF02146.15 MSTRG.14745.7_3 - 2e-13 50.5 0.0 2.7e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.11 MSTRG.14745.7_3 - 0.0055 16.3 0.8 0.007 16.0 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF592) DUF1011 PF06237.10 MSTRG.9951.1_1 - 2.1e-37 127.3 7.2 2.1e-37 127.3 7.2 3.1 3 0 0 3 3 3 1 Protein of unknown function (DUF1011) T_Ag_DNA_bind PF02217.14 MSTRG.24857.1_1 - 0.053 14.0 0.7 0.072 13.6 0.7 1.2 1 0 0 1 1 1 0 Origin of replication binding protein IMPDH PF00478.23 MSTRG.19709.1_2 - 2.6e-79 266.6 2.4 5.8e-79 265.5 2.4 1.5 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.16 MSTRG.19709.1_2 - 0.0017 17.3 2.7 0.0033 16.4 2.5 1.5 1 1 0 1 1 1 1 FMN-dependent dehydrogenase TGF_beta_GS PF08515.10 MSTRG.19709.1_2 - 0.053 12.9 0.1 0.15 11.4 0.1 1.9 1 0 0 1 1 1 0 Transforming growth factor beta type I GS-motif Aldolase PF01081.17 MSTRG.19709.1_2 - 0.084 12.2 0.3 0.58 9.4 0.0 2.0 2 0 0 2 2 2 0 KDPG and KHG aldolase Glu_synthase PF01645.15 MSTRG.19709.1_2 - 0.12 11.3 1.2 0.19 10.7 1.2 1.2 1 0 0 1 1 1 0 Conserved region in glutamate synthase SAM_2 PF07647.15 MSTRG.6579.1_2 - 0.11 12.4 0.3 0.26 11.3 0.3 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) zf-H2C2_2 PF13465.4 MSTRG.23070.1_3 - 2e-12 46.8 8.5 3.1e-07 30.4 1.9 4.3 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.23070.1_3 - 4.3e-09 36.2 22.9 0.0081 16.4 4.1 4.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.23070.1_3 - 0.0027 18.3 2.9 0.0027 18.3 2.9 5.9 6 0 0 6 6 6 3 C2H2-type zinc finger SKA2 PF16740.3 MSTRG.27492.1_2 - 0.2 11.3 1.6 26 4.5 0.0 3.0 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 2 zf-H2C2_2 PF13465.4 MSTRG.23885.1_2 - 2e-33 113.2 85.4 1.3e-09 38.0 0.9 14.1 15 0 0 15 15 14 7 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.23885.1_2 - 4.4e-24 82.9 93.2 0.0021 18.6 2.0 12.0 12 0 0 12 12 11 8 C2H2-type zinc finger zf-C2H2 PF00096.24 MSTRG.23885.1_2 - 2.2e-22 78.1 95.3 0.0013 18.9 1.1 11.5 11 0 0 11 11 11 8 Zinc finger, C2H2 type zf-C2H2_2 PF12756.5 MSTRG.23885.1_2 - 3.3e-06 27.2 50.4 0.23 11.7 1.2 8.8 5 3 3 8 8 8 5 C2H2 type zinc-finger (2 copies) zf-met PF12874.5 MSTRG.23885.1_2 - 0.0001 22.4 65.3 0.0019 18.4 1.1 10.7 10 0 0 10 10 10 4 Zinc-finger of C2H2 type zf-Di19 PF05605.10 MSTRG.23885.1_2 - 0.00051 20.1 2.1 0.00051 20.1 2.1 7.0 5 2 1 7 7 7 4 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.4 MSTRG.23885.1_2 - 0.00096 18.9 0.8 0.00096 18.9 0.8 10.7 11 0 0 11 11 10 4 C2H2-type zinc finger zf-C2H2_11 PF16622.3 MSTRG.23885.1_2 - 0.0016 18.0 1.2 0.0016 18.0 1.2 7.8 8 0 0 8 8 7 2 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 MSTRG.23885.1_2 - 0.035 14.3 46.9 0.36 11.1 0.0 9.6 9 0 0 9 9 9 0 Zinc-finger double-stranded RNA-binding zf-MIZ PF02891.18 MSTRG.23885.1_2 - 0.24 11.1 0.1 0.24 11.1 0.1 5.6 6 2 1 7 7 6 0 MIZ/SP-RING zinc finger DUF416 PF04222.10 MSTRG.23885.1_2 - 0.25 10.6 3.3 1 8.6 2.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF416) DASH_Spc19 PF08287.9 MSTRG.23885.1_2 - 0.72 9.6 14.0 1.1 9.0 5.3 3.5 3 0 0 3 3 3 0 Spc19 zf-C2HE PF16278.3 MSTRG.23885.1_2 - 3.6 8.0 46.2 0.86 10.0 0.0 8.2 6 2 1 7 7 5 0 C2HE / C2H2 / C2HC zinc-binding finger DUF2225 PF09986.7 MSTRG.23885.1_2 - 5.1 6.6 22.6 4.4 6.8 2.4 5.7 5 1 0 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2225) RNA_pol_Rpb5_C PF01191.17 MSTRG.23677.1_2 - 1.4e-35 120.8 0.3 2.7e-35 119.9 0.3 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.12 MSTRG.23677.1_2 - 3.3e-35 120.4 0.2 5.8e-35 119.6 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain FumaraseC_C PF10415.7 MSTRG.23677.1_2 - 0.057 13.7 0.5 2.1 8.7 0.0 2.5 2 0 0 2 2 2 0 Fumarase C C-terminus Drf_GBD PF06371.11 MSTRG.15740.1_3 - 2.2e-17 63.1 3.1 2.9e-17 62.7 3.1 1.2 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain IFT20 PF14931.4 MSTRG.23387.1_2 - 7.1e-40 135.8 5.6 1.2e-39 135.0 5.6 1.4 1 0 0 1 1 1 1 Intraflagellar transport complex B, subunit 20 MHC_I PF00129.16 MSTRG.23387.1_2 - 1.2e-30 106.3 2.7 1.9e-30 105.6 2.7 1.3 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 MSTRG.23387.1_2 - 6.7e-09 36.0 0.0 1.6e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin C1-set domain TMEM154 PF15102.4 MSTRG.23387.1_2 - 0.067 13.0 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 TMEM154 protein family Fe_hyd_lg_C PF02906.12 MSTRG.23387.1_2 - 0.068 12.7 0.1 2.2 7.8 0.0 2.2 2 0 0 2 2 2 0 Iron only hydrogenase large subunit, C-terminal domain DUF1045 PF06299.10 MSTRG.23387.1_2 - 0.12 12.2 0.1 0.26 11.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1045) DUF912 PF06024.10 MSTRG.23387.1_2 - 0.16 12.1 0.1 0.16 12.1 0.1 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Septin PF00735.16 MSTRG.12151.4_3 - 1.5e-124 414.7 0.0 1.9e-124 414.3 0.0 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 MSTRG.12151.4_3 - 1.2e-07 31.7 0.0 3e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 MSTRG.12151.4_3 - 3.2e-05 23.7 0.1 0.0024 17.6 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 MSTRG.12151.4_3 - 6.4e-05 22.4 0.1 0.0094 15.4 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AIG1 PF04548.14 MSTRG.12151.4_3 - 0.00026 20.2 0.0 0.0005 19.3 0.0 1.4 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.21 MSTRG.12151.4_3 - 0.0012 18.8 0.2 0.23 11.4 0.0 2.7 1 1 1 2 2 2 1 Dynamin family Ras PF00071.20 MSTRG.12151.4_3 - 0.0019 17.7 0.0 0.0035 16.8 0.0 1.5 1 0 0 1 1 1 1 Ras family AAA_22 PF13401.4 MSTRG.12151.4_3 - 0.011 15.9 0.3 0.039 14.1 0.0 2.2 2 1 0 2 2 2 0 AAA domain Roc PF08477.11 MSTRG.12151.4_3 - 0.013 15.6 0.0 0.023 14.8 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.25 MSTRG.12151.4_3 - 0.024 15.0 0.0 0.051 14.0 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.4 MSTRG.12151.4_3 - 0.026 14.8 0.0 0.058 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.4 MSTRG.12151.4_3 - 0.03 13.9 0.0 0.058 13.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Gtr1_RagA PF04670.10 MSTRG.12151.4_3 - 0.075 12.2 0.3 0.52 9.5 0.0 2.1 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region Galanin PF01296.16 MSTRG.25916.1_2 - 0.0082 16.0 0.4 0.017 15.0 0.4 1.5 1 0 0 1 1 1 1 Galanin CBFD_NFYB_HMF PF00808.21 MSTRG.23256.3_3 - 5.5e-21 74.5 2.4 1.3e-20 73.3 1.6 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.22 MSTRG.23256.3_3 - 5.2e-15 55.9 0.7 1.1e-14 54.9 0.7 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.8 MSTRG.23256.3_3 - 0.13 12.5 0.3 0.3 11.3 0.1 1.7 2 0 0 2 2 2 0 CENP-S associating Centromere protein X CC190 PF15768.3 MSTRG.16434.1_3 - 0.021 14.8 0.3 0.037 14.0 0.3 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 190 EF-hand_7 PF13499.4 MSTRG.540.1_1 - 7.2e-29 99.9 9.6 9.2e-16 57.9 3.3 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 MSTRG.540.1_1 - 8.7e-29 96.8 22.7 1.9e-08 33.1 1.3 4.2 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.4 MSTRG.540.1_1 - 8.5e-25 86.2 15.1 6.4e-13 48.1 2.7 3.7 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.540.1_1 - 1.2e-22 77.8 14.1 3.6e-06 26.4 0.3 4.6 4 1 1 5 5 5 4 EF-hand domain EF-hand_5 PF13202.4 MSTRG.540.1_1 - 6.9e-19 66.3 19.3 4.2e-06 25.9 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.4 MSTRG.540.1_1 - 5.2e-12 45.8 0.5 1.2e-06 28.6 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 MSTRG.540.1_1 - 8.1e-06 25.6 8.6 0.067 13.0 0.5 3.6 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 MSTRG.540.1_1 - 0.00028 21.1 0.4 0.096 12.9 0.1 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.9 MSTRG.540.1_1 - 0.0012 19.6 0.0 0.93 10.3 0.0 2.2 1 1 1 2 2 2 2 EF-hand domain TerB PF05099.11 MSTRG.540.1_1 - 0.058 13.2 0.1 10 5.9 0.0 2.2 1 1 1 2 2 2 0 Tellurite resistance protein TerB DHR-2 PF06920.11 MSTRG.10947.1_1 - 9.5e-123 410.5 2.1 1.2e-122 410.1 2.1 1.1 1 0 0 1 1 1 1 Dock homology region 2 DHR-2 PF06920.11 MSTRG.10947.1_2 - 4.3e-84 282.9 0.6 6.4e-84 282.4 0.6 1.2 1 0 0 1 1 1 1 Dock homology region 2 API5 PF05918.9 MSTRG.29731.1_1 - 6.1 5.4 5.1 6.9 5.2 5.1 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) HSP70 PF00012.18 MSTRG.11192.1_3 - 5.8e-97 325.2 12.6 5.8e-97 325.2 12.6 2.5 2 1 1 3 3 3 2 Hsp70 protein MreB_Mbl PF06723.11 MSTRG.11192.1_3 - 7e-05 21.7 0.3 0.0043 15.8 0.0 2.4 2 0 0 2 2 2 2 MreB/Mbl protein FLO_LFY PF01698.14 MSTRG.11192.1_3 - 0.058 12.5 8.0 0.12 11.5 8.0 1.4 1 0 0 1 1 1 0 Floricaula / Leafy protein EF-hand_2 PF09068.9 MSTRG.25309.1_3 - 9.7e-41 138.6 1.2 9.7e-41 138.6 1.2 2.2 2 0 0 2 2 2 1 EF hand EF-hand_3 PF09069.9 MSTRG.25309.1_3 - 2e-39 133.8 0.1 2.4e-38 130.3 0.0 2.9 2 0 0 2 2 2 1 EF-hand Spectrin PF00435.19 MSTRG.25309.1_3 - 1.6e-33 115.2 42.9 2.5e-09 37.4 5.4 6.4 4 2 0 5 5 5 5 Spectrin repeat ZZ PF00569.15 MSTRG.25309.1_3 - 1.5e-19 69.4 4.2 3.1e-19 68.4 4.2 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type TRPM_tetra PF16519.3 MSTRG.25309.1_3 - 0.073 13.1 2.5 1.9 8.5 0.0 4.2 4 0 0 4 4 4 0 Tetramerisation domain of TRPM MSC PF09402.8 MSTRG.25309.1_3 - 0.087 12.2 9.7 0.23 10.8 1.6 3.5 3 0 0 3 3 3 0 Man1-Src1p-C-terminal domain Peptidase_M9_N PF08453.8 MSTRG.25309.1_3 - 0.096 12.3 4.0 0.15 11.6 0.3 2.9 2 1 1 3 3 3 0 Peptidase family M9 N-terminal Reo_sigmaC PF04582.10 MSTRG.25309.1_3 - 1.2 8.3 7.6 8.1 5.6 1.1 3.4 2 1 1 3 3 3 0 Reovirus sigma C capsid protein DUF4936 PF16290.3 MSTRG.25309.1_3 - 1.3 9.7 6.8 2.9 8.5 0.2 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4936) DUF342 PF03961.11 MSTRG.25309.1_3 - 2 6.8 6.5 8.8 4.7 2.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF342) Fib_alpha PF08702.8 MSTRG.25309.1_3 - 4.3 7.4 13.1 0.94 9.5 6.6 3.3 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family PilJ PF13675.4 MSTRG.25309.1_3 - 4.8 7.1 17.2 0.22 11.5 2.1 4.3 3 2 2 5 5 5 0 Type IV pili methyl-accepting chemotaxis transducer N-term zf-CCHC PF00098.21 MSTRG.16686.1_1 - 4.2e-17 61.2 22.2 5.3e-06 26.1 0.6 4.4 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_2 PF13696.4 MSTRG.16686.1_1 - 1.3e-07 31.2 21.9 0.0024 17.5 1.0 4.4 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_4 PF14392.4 MSTRG.16686.1_1 - 0.00019 21.0 22.0 0.045 13.3 0.5 4.7 4 1 0 4 4 4 4 Zinc knuckle eIF3g PF12353.6 MSTRG.16686.1_1 - 0.072 13.4 17.2 0.22 11.8 1.4 3.5 2 1 1 3 3 3 0 Eukaryotic translation initiation factor 3 subunit G zf-C2H2_10 PF16588.3 MSTRG.16686.1_1 - 0.17 11.5 4.6 0.59 9.8 0.1 2.7 2 0 0 2 2 2 0 C2H2 zinc-finger zf-C4 PF00105.16 MSTRG.23048.2_3 - 2.5e-32 111.0 16.8 2.5e-32 111.0 16.8 2.0 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 MSTRG.23048.2_3 - 4.3e-22 78.6 0.0 7.5e-22 77.8 0.0 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor PPI_Ypi1 PF07491.9 MSTRG.25236.2_1 - 4.6e-21 74.3 4.2 8.4e-21 73.4 4.2 1.4 1 0 0 1 1 1 1 Protein phosphatase inhibitor MRF_C1 PF13887.4 MSTRG.21040.3_3 - 0.17 10.9 0.4 0.35 9.9 0.4 1.4 1 0 0 1 1 1 0 Myelin gene regulatory factor -C-terminal domain 1 zf-H2C2_2 PF13465.4 MSTRG.21501.1_3 - 7.2e-63 206.3 92.4 9e-08 32.1 0.3 14.7 15 0 0 15 15 15 11 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.21501.1_3 - 2.4e-42 140.9 118.5 1.6e-05 24.9 1.8 13.7 14 0 0 14 14 13 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.21501.1_3 - 6.5e-40 132.2 105.3 7.4e-05 23.1 0.9 14.4 14 0 0 14 14 14 13 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.21501.1_3 - 2.2e-19 69.1 55.3 0.0025 18.0 0.2 12.5 12 0 0 12 12 12 7 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 MSTRG.21501.1_3 - 6.5e-12 45.0 84.9 0.027 14.3 0.5 13.5 13 1 0 13 13 13 7 C2H2-type zinc finger zf-met PF12874.5 MSTRG.21501.1_3 - 3.2e-11 43.1 70.7 0.0029 17.8 0.4 12.9 13 0 0 13 13 13 4 Zinc-finger of C2H2 type zf-Di19 PF05605.10 MSTRG.21501.1_3 - 1.3e-09 38.1 71.8 0.0058 16.7 1.6 7.5 7 1 0 8 8 7 6 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.3 MSTRG.21501.1_3 - 3.6e-05 23.9 54.1 0.024 14.8 3.3 7.5 3 3 3 7 7 7 4 C2H2-type zinc ribbon zf-C2H2_2 PF12756.5 MSTRG.21501.1_3 - 0.00041 20.5 72.5 0.13 12.5 7.8 10.4 4 3 6 10 10 10 3 C2H2 type zinc-finger (2 copies) zf-C2HE PF16278.3 MSTRG.21501.1_3 - 0.0031 17.8 1.0 0.0031 17.8 1.0 11.4 4 3 7 12 12 12 1 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_5 PF13909.4 MSTRG.21501.1_3 - 0.0046 16.6 0.4 0.0046 16.6 0.4 11.3 11 1 0 11 11 10 3 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.3 MSTRG.21501.1_3 - 0.041 13.5 0.2 0.041 13.5 0.2 8.3 9 0 0 9 9 9 0 zinc-finger C2H2-type YbgS PF13985.4 MSTRG.21501.1_3 - 0.24 11.6 9.1 0.047 13.8 5.1 1.9 2 0 0 2 2 1 0 YbgS-like protein BolA PF01722.16 MSTRG.21501.1_3 - 1.3 9.2 22.9 0.44 10.7 1.0 5.7 5 2 0 6 6 5 0 BolA-like protein zf-C2H2_9 PF16293.3 MSTRG.21501.1_3 - 1.5 8.6 23.4 2 8.2 0.2 7.6 6 2 2 8 8 7 0 C2H2 type zinc-finger (1 copy) Rad50_zn_hook PF04423.12 MSTRG.21501.1_3 - 2 8.2 12.1 8.5 6.2 0.2 5.0 5 0 0 5 5 4 0 Rad50 zinc hook motif zinc_ribbon_15 PF17032.3 MSTRG.21501.1_3 - 6.5 7.5 38.7 16 6.2 0.4 7.4 3 3 4 7 7 7 0 zinc-ribbon family GAGA PF09237.9 MSTRG.21501.1_3 - 7.3 6.4 15.9 2.4 7.9 0.1 4.8 4 2 2 6 6 5 0 GAGA factor zf-FPG_IleRS PF06827.12 MSTRG.21501.1_3 - 8.6 6.2 19.4 1.8 8.4 0.1 6.6 6 0 0 6 6 6 0 Zinc finger found in FPG and IleRS FKBP_C PF00254.26 MSTRG.22657.1_1 - 1.6e-31 108.3 0.0 3e-31 107.5 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase HATPase_c_2 PF13581.4 MSTRG.22657.1_1 - 0.045 13.6 0.0 0.072 12.9 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Pkinase_Tyr PF07714.15 MSTRG.17978.1_1 - 3.9e-63 213.0 0.0 5.3e-63 212.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.17978.1_1 - 5.2e-59 199.6 0.0 7.6e-59 199.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH3_9 PF14604.4 MSTRG.17978.1_1 - 3.1e-12 46.0 0.5 6e-12 45.1 0.1 1.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.17978.1_1 - 8.6e-12 44.3 0.1 1.5e-11 43.6 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.17978.1_1 - 2.1e-09 36.8 0.0 4.4e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF3552 PF12072.6 MSTRG.17978.1_1 - 0.092 12.0 11.0 0.16 11.2 11.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Tmem26 PF09772.7 MSTRG.23457.1_3 - 0.01 15.1 0.1 0.015 14.5 0.1 1.2 1 0 0 1 1 1 0 Transmembrane protein 26 zf-CCCH_3 PF15663.3 MSTRG.6041.3_2 - 2.7e-54 182.0 8.5 9.5e-54 180.2 8.5 1.9 1 0 0 1 1 1 1 Zinc-finger containing family Ig_3 PF13927.4 MSTRG.21596.1_3 - 0.00013 22.4 0.1 0.23 12.0 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.21596.1_3 - 0.003 17.8 0.0 0.15 12.3 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.15 MSTRG.21596.1_3 - 0.052 13.6 0.0 0.54 10.3 0.0 2.5 2 1 0 2 2 2 0 Immunoglobulin V-set domain Cadherin_C_2 PF16492.3 MSTRG.21596.1_3 - 0.078 13.6 0.0 0.2 12.3 0.0 1.7 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal WD40 PF00400.30 MSTRG.1509.1_3 - 3.1e-07 30.8 1.3 0.038 14.7 0.0 4.8 4 0 0 4 4 4 2 WD domain, G-beta repeat Sec16_C PF12931.5 MSTRG.1509.1_3 - 1.1e-06 28.4 0.1 1.2e-05 25.0 0.1 2.4 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 MukF_M PF17192.2 MSTRG.1509.1_3 - 0.099 12.2 0.1 0.21 11.2 0.1 1.5 1 0 0 1 1 1 0 MukF middle domain TPP_enzyme_N PF02776.16 MSTRG.14569.2_1 - 0.16 11.4 0.0 0.17 11.3 0.0 1.0 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Cadherin_3 PF16184.3 MSTRG.24340.1_1 - 5.3e-89 293.5 0.0 4.5e-19 68.4 0.0 5.1 5 0 0 5 5 5 5 Cadherin-like ELYS-bb PF16687.3 MSTRG.2122.1_1 - 5.5e-283 938.7 0.1 1.3e-282 937.5 0.0 1.6 2 0 0 2 2 2 1 beta-propeller of ELYS nucleoporin ELYS PF13934.4 MSTRG.2122.1_1 - 1.3e-52 178.8 0.2 2.2e-52 178.1 0.2 1.4 1 0 0 1 1 1 1 Nuclear pore complex assembly C1q PF00386.19 MSTRG.23422.1_2 - 6.1e-22 78.1 0.2 7.9e-22 77.7 0.2 1.2 1 0 0 1 1 1 1 C1q domain SSF PF00474.15 MSTRG.24330.1_2 - 3.1e-72 243.6 18.1 3.5e-72 243.4 18.1 1.0 1 0 0 1 1 1 1 Sodium:solute symporter family zf-HC5HC2H_2 PF13832.4 MSTRG.7242.1_1 - 1.4e-30 105.5 5.7 1.4e-30 105.5 5.7 3.2 3 0 0 3 3 3 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.4 MSTRG.7242.1_1 - 9.8e-24 83.3 5.7 9.8e-24 83.3 5.7 3.8 4 0 0 4 4 4 1 PHD-like zinc-binding domain PHD_2 PF13831.4 MSTRG.7242.1_1 - 4.2e-12 45.2 7.3 4.2e-12 45.2 7.3 3.7 3 0 0 3 3 3 1 PHD-finger PHD PF00628.27 MSTRG.7242.1_1 - 4.6e-10 39.1 9.5 4.6e-10 39.1 9.5 3.5 3 0 0 3 3 3 2 PHD-finger EPL1 PF10513.7 MSTRG.7242.1_1 - 4.3e-05 23.8 0.1 0.00011 22.4 0.1 1.7 1 0 0 1 1 1 1 Enhancer of polycomb-like C1_1 PF00130.20 MSTRG.7242.1_1 - 0.0086 15.8 3.9 0.0086 15.8 3.9 4.0 3 1 0 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase PF00069.23 MSTRG.25997.1_3 - 7.4e-41 140.1 0.1 8.7e-41 139.9 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.25997.1_3 - 2e-20 73.1 0.5 2.3e-20 72.8 0.5 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 MSTRG.25997.1_3 - 1.5e-06 28.2 0.0 0.0035 17.2 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.4 MSTRG.25997.1_3 - 0.00011 21.5 0.0 0.00081 18.7 0.0 1.9 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.20 MSTRG.25997.1_3 - 0.00076 19.0 0.1 0.0012 18.3 0.1 1.3 1 1 0 1 1 1 1 RIO1 family Kdo PF06293.12 MSTRG.25997.1_3 - 0.0044 16.3 0.1 0.0096 15.2 0.1 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 MSTRG.25997.1_3 - 0.025 14.1 0.0 1.8 8.0 0.0 2.1 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Seadorna_VP7 PF07387.9 MSTRG.25997.1_3 - 0.039 12.9 0.0 0.057 12.3 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Transglut_N PF00868.18 MSTRG.7008.2_3 - 6.8e-36 123.1 0.1 1.1e-35 122.4 0.1 1.3 1 0 0 1 1 1 1 Transglutaminase family TMEM223 PF14640.4 MSTRG.11430.1_3 - 0.0011 19.1 0.0 0.0018 18.3 0.0 1.3 1 0 0 1 1 1 1 Transmembrane protein 223 ITAM_Cys-rich PF10538.7 MSTRG.22320.1_3 - 4 7.1 8.8 0.56 9.9 1.7 2.5 2 0 0 2 2 2 0 Immunoreceptor tyrosine-based activation motif PH PF00169.27 MSTRG.22508.3_3 - 3e-10 40.4 0.1 5.4e-10 39.6 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 MSTRG.22508.3_3 - 0.0001 22.6 0.2 0.0001 22.6 0.2 1.5 2 0 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.4 MSTRG.22508.3_3 - 0.015 15.5 0.0 0.026 14.7 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain Pkinase PF00069.23 MSTRG.5545.2_2 - 1.6e-22 80.0 0.5 1.9e-22 79.8 0.5 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.5545.2_2 - 7.5e-16 58.1 0.3 9e-16 57.8 0.3 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase TF_AP-2 PF03299.12 MSTRG.10755.1_1 - 3e-88 294.8 0.0 4.1e-88 294.4 0.0 1.2 1 0 0 1 1 1 1 Transcription factor AP-2 DUF2624 PF11116.6 MSTRG.10755.1_1 - 0.055 14.2 0.0 0.11 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2624) VWA PF00092.26 MSTRG.24405.2_3 - 4.3e-58 196.3 1.1 5.7e-47 160.1 0.0 2.1 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.4 MSTRG.24405.2_3 - 5.8e-22 78.2 0.0 1.5e-16 60.8 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_3 PF13768.4 MSTRG.24405.2_3 - 0.00045 20.0 0.1 0.017 14.9 0.0 2.3 2 0 0 2 2 2 1 von Willebrand factor type A domain SRPRB PF09439.8 MSTRG.24405.2_3 - 0.00055 19.3 0.0 0.04 13.2 0.0 2.2 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit SSP160 PF06933.9 MSTRG.24405.2_3 - 0.66 8.0 7.9 0.92 7.5 7.9 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Ribosomal_60s PF00428.17 MSTRG.29478.1_3 - 2.2 8.7 8.7 3.5 8.1 8.7 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein Pkinase PF00069.23 MSTRG.28669.1_2 - 0.0025 17.1 0.0 0.0027 17.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain RAI1 PF08652.9 MSTRG.8195.1_1 - 1.7e-21 76.0 0.0 3.2e-21 75.2 0.0 1.4 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease Occludin_ELL PF07303.11 MSTRG.10383.2_1 - 2.6e-13 50.4 1.5 5.4e-13 49.4 1.5 1.5 1 0 0 1 1 1 1 Occludin homology domain MARVEL PF01284.21 MSTRG.10383.2_1 - 9.7e-12 45.0 8.9 1.5e-11 44.3 8.9 1.3 1 0 0 1 1 1 1 Membrane-associating domain bZIP_1 PF00170.19 MSTRG.25420.1_1 - 5e-12 45.6 4.8 7.5e-12 45.0 4.8 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 MSTRG.25420.1_1 - 1.1e-08 34.9 4.4 1.8e-08 34.2 4.4 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 MSTRG.25420.1_1 - 0.016 15.6 5.4 0.028 14.8 5.4 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor zf-C2H2 PF00096.24 MSTRG.25420.1_3 - 0.017 15.4 1.5 0.017 15.4 1.5 3.7 3 1 0 3 3 3 0 Zinc finger, C2H2 type ERG2_Sigma1R PF04622.10 MSTRG.9902.1_1 - 3.6e-66 222.3 1.2 5.1e-66 221.9 1.2 1.1 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein Myelin_PLP PF01275.17 MSTRG.22987.1_2 - 8.9e-98 326.7 20.6 1.5e-97 326.0 20.6 1.4 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) DNA_methylase PF00145.15 MSTRG.20200.2_2 - 1.3e-16 60.8 0.0 1.2e-12 47.7 0.0 2.2 2 0 0 2 2 2 2 C-5 cytosine-specific DNA methylase LacI PF00356.19 MSTRG.20200.2_3 - 6 6.6 5.7 5.1 6.8 0.3 2.3 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family Sema PF01403.17 MSTRG.9350.1_2 - 5.2e-142 473.4 0.0 6.9e-142 473.0 0.0 1.2 1 0 0 1 1 1 1 Sema domain ig PF00047.23 MSTRG.9350.1_2 - 0.0002 21.3 0.0 0.00047 20.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain PSI PF01437.23 MSTRG.9350.1_2 - 0.00097 19.5 6.6 0.0046 17.3 6.6 2.2 1 0 0 1 1 1 1 Plexin repeat I-set PF07679.14 MSTRG.9350.1_2 - 0.15 12.0 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain PLU-1 PF08429.9 MSTRG.21846.2_2 - 7.5e-102 340.8 18.0 9.1e-98 327.3 12.8 2.9 3 0 0 3 3 3 2 PLU-1-like protein JmjC PF02373.20 MSTRG.21846.2_2 - 1.3e-44 151.2 1.1 3.5e-44 149.8 1.1 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.27 MSTRG.21846.2_2 - 2.1e-22 78.6 52.6 1.5e-12 47.1 4.0 4.2 4 0 0 4 4 4 3 PHD-finger zf-C5HC2 PF02928.14 MSTRG.21846.2_2 - 2.8e-17 62.7 17.8 1.6e-16 60.2 17.8 2.5 1 0 0 1 1 1 1 C5HC2 zinc finger ARID PF01388.19 MSTRG.21846.2_2 - 7.6e-17 61.6 0.0 2.4e-16 60.0 0.0 2.0 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.15 MSTRG.21846.2_2 - 7.1e-15 54.5 0.3 1.9e-14 53.2 0.3 1.8 1 0 0 1 1 1 1 jmjN domain Methyltransf_15 PF09445.8 MSTRG.7056.3_2 - 2e-45 154.4 0.0 2.9e-45 153.8 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.4 MSTRG.7056.3_2 - 1.4e-06 28.7 0.0 5.9e-06 26.8 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.16 MSTRG.7056.3_2 - 6.8e-06 25.8 0.0 2.9e-05 23.7 0.0 1.9 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Met_10 PF02475.14 MSTRG.7056.3_2 - 2.2e-05 24.2 0.0 3.9e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_11 PF08241.10 MSTRG.7056.3_2 - 0.0012 19.3 0.0 0.0045 17.4 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.11 MSTRG.7056.3_2 - 0.0013 18.1 0.0 0.0032 16.8 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.13 MSTRG.7056.3_2 - 0.0038 16.8 0.0 0.007 15.9 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.12 MSTRG.7056.3_2 - 0.17 11.3 0.0 0.3 10.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Jnk-SapK_ap_N PF09744.7 MSTRG.14455.3_2 - 0.22 11.6 2.2 0.35 10.9 2.2 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 IncA PF04156.12 MSTRG.14455.3_3 - 0.00012 21.7 21.3 0.00029 20.5 1.7 2.2 2 0 0 2 2 2 2 IncA protein Fez1 PF06818.13 MSTRG.14455.3_3 - 0.0049 17.2 22.0 0.12 12.7 4.5 2.2 2 0 0 2 2 2 2 Fez1 HALZ PF02183.16 MSTRG.14455.3_3 - 0.0054 16.8 12.4 0.014 15.5 0.3 2.7 2 0 0 2 2 2 1 Homeobox associated leucine zipper Filament PF00038.19 MSTRG.14455.3_3 - 0.011 15.2 3.4 0.011 15.2 3.4 2.7 2 1 0 3 3 3 0 Intermediate filament protein CALCOCO1 PF07888.9 MSTRG.14455.3_3 - 0.025 13.0 21.4 0.11 10.9 11.5 2.1 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Nsp1_C PF05064.11 MSTRG.14455.3_3 - 0.033 13.9 1.5 8.5 6.1 0.0 2.3 2 0 0 2 2 2 0 Nsp1-like C-terminal region ZapB PF06005.10 MSTRG.14455.3_3 - 0.079 13.3 0.2 0.079 13.3 0.2 4.1 3 1 1 4 4 3 0 Cell division protein ZapB CASP_C PF08172.10 MSTRG.14455.3_3 - 0.28 10.3 0.0 0.28 10.3 0.0 2.5 3 0 0 3 3 3 0 CASP C terminal TSC22 PF01166.16 MSTRG.14455.3_3 - 0.58 10.4 5.5 3.7 7.8 1.3 2.7 2 0 0 2 2 2 0 TSC-22/dip/bun family Leu_zip PF15294.4 MSTRG.14455.3_3 - 0.6 9.4 11.3 2.4 7.4 1.4 3.0 3 0 0 3 3 3 0 Leucine zipper TBPIP PF07106.11 MSTRG.14455.3_3 - 1.2 8.7 12.0 2.6 7.6 1.9 3.1 3 0 0 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Rootletin PF15035.4 MSTRG.14455.3_3 - 1.3 8.9 15.8 3.8 7.4 1.3 3.3 3 0 0 3 3 3 0 Ciliary rootlet component, centrosome cohesion Spc7 PF08317.9 MSTRG.14455.3_3 - 2.2 7.0 20.1 0.23 10.2 1.1 2.6 2 1 0 2 2 2 0 Spc7 kinetochore protein GAS PF13851.4 MSTRG.14455.3_3 - 2.9 7.1 17.6 3.2 7.0 5.7 2.6 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Cep57_MT_bd PF06657.11 MSTRG.14455.3_3 - 3 8.2 10.2 2.2 8.7 6.8 2.5 2 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 KLRAQ PF10205.7 MSTRG.14455.3_3 - 4.2 7.5 9.1 0.83 9.8 1.2 3.0 3 1 0 3 3 3 0 Predicted coiled-coil domain-containing protein DUF3972 PF13118.4 MSTRG.14455.3_3 - 5.9 7.2 6.4 0.76 10.1 0.1 2.3 3 0 0 3 3 2 0 Protein of unknown function (DUF3972) ERM PF00769.17 MSTRG.14455.3_3 - 6 6.5 40.4 0.068 12.9 6.6 2.8 2 1 0 2 2 2 0 Ezrin/radixin/moesin family DUF972 PF06156.11 MSTRG.14455.3_3 - 6.5 7.3 11.1 6.9 7.2 2.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF972) KASH_CCD PF14662.4 MSTRG.14455.3_3 - 9.5 5.9 24.5 0.45 10.2 5.3 3.1 3 0 0 3 3 3 0 Coiled-coil region of CCDC155 or KASH CENP-F_leu_zip PF10473.7 MSTRG.14455.3_3 - 9.9 6.1 25.5 0.31 10.9 4.7 3.2 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 p31comet PF06581.10 MSTRG.7769.1_1 - 5.5e-69 232.1 1.5 8.2e-69 231.5 1.5 1.2 1 0 0 1 1 1 1 Mad1 and Cdc20-bound-Mad2 binding Inositol_P PF00459.23 MSTRG.9061.1_3 - 1.7e-69 234.2 0.1 2e-69 234.0 0.1 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family Cadherin PF00028.15 MSTRG.4236.1_3 - 2.2e-80 265.1 1.8 3.2e-18 65.8 0.1 5.7 5 0 0 5 5 5 5 Cadherin domain Cadherin_2 PF08266.10 MSTRG.4236.1_3 - 0.00031 20.3 0.0 0.98 9.1 0.0 3.8 3 0 0 3 3 3 2 Cadherin-like KASH_CCD PF14662.4 MSTRG.17381.1_2 - 2e-17 63.6 5.4 3e-17 63.0 5.4 1.3 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH EF-hand_9 PF14658.4 MSTRG.17381.1_2 - 9.9e-14 51.3 0.1 3.4e-13 49.6 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain DUF972 PF06156.11 MSTRG.17381.1_2 - 0.0043 17.5 1.5 0.0088 16.5 1.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF972) DUF1664 PF07889.10 MSTRG.17381.1_2 - 0.11 12.4 1.6 0.21 11.5 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) ADIP PF11559.6 MSTRG.17381.1_2 - 0.18 11.7 6.9 0.38 10.7 6.9 1.5 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding TMPIT PF07851.11 MSTRG.17381.1_2 - 0.74 8.9 4.3 1.2 8.2 4.3 1.3 1 0 0 1 1 1 0 TMPIT-like protein CENP-H PF05837.10 MSTRG.17381.1_2 - 2.7 8.3 10.8 0.68 10.2 7.4 1.7 2 0 0 2 2 2 0 Centromere protein H (CENP-H) ZapB PF06005.10 MSTRG.17381.1_2 - 3.3 8.1 8.4 2.5 8.5 0.5 2.6 2 1 1 3 3 3 0 Cell division protein ZapB IncA PF04156.12 MSTRG.17381.1_2 - 4.7 6.8 12.1 8.5 6.0 12.1 1.6 1 1 0 1 1 1 0 IncA protein DUF5082 PF16888.3 MSTRG.17381.1_2 - 5.9 7.1 8.9 0.97 9.7 0.3 2.6 2 1 0 3 3 3 0 Domain of unknown function (DUF5082) Peptidase_S28 PF05577.10 MSTRG.27218.1_2 - 2e-139 465.0 0.0 2.3e-139 464.8 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_1 PF00561.18 MSTRG.27218.1_2 - 0.0054 16.3 0.0 0.013 15.1 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Phage_C PF12025.6 MSTRG.27218.1_2 - 0.14 11.9 0.0 0.33 10.7 0.0 1.5 1 0 0 1 1 1 0 Phage protein C Sulfate_transp PF00916.18 MSTRG.15897.1_3 - 1.1e-126 422.5 18.1 1.6e-126 422.0 18.1 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.19 MSTRG.15897.1_3 - 6.7e-23 80.4 0.0 1.1e-22 79.7 0.0 1.4 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.4 MSTRG.15897.1_3 - 0.0099 16.1 0.3 0.021 15.0 0.3 1.5 1 0 0 1 1 1 1 STAS domain PDZ PF00595.22 MSTRG.13646.2_2 - 3.8e-70 232.1 8.8 5.8e-13 48.9 0.1 6.4 6 0 0 6 6 6 6 PDZ domain (Also known as DHR or GLGF) MAGI_u5 PF16666.3 MSTRG.13646.2_2 - 1.3e-33 115.8 13.5 1.3e-33 115.8 13.5 4.7 5 1 0 5 5 5 1 Unstructured region on MAGI PDZ_2 PF13180.4 MSTRG.13646.2_2 - 1.3e-27 95.8 1.2 0.00017 21.7 0.0 6.0 6 0 0 6 6 6 5 PDZ domain MAGI_u1 PF16663.3 MSTRG.13646.2_2 - 1.4e-19 69.7 0.9 1.4e-19 69.7 0.9 2.8 3 0 0 3 3 3 1 Unstructured region on MAGI WW PF00397.24 MSTRG.13646.2_2 - 5.1e-18 64.6 5.6 7.4e-10 38.5 0.3 2.7 2 0 0 2 2 2 2 WW domain Guanylate_kin PF00625.19 MSTRG.13646.2_2 - 1e-10 41.5 0.0 2e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Guanylate kinase Tricorn_PDZ PF14685.4 MSTRG.13646.2_2 - 4.9e-06 26.3 8.8 1.8 8.5 0.0 5.8 6 0 0 6 6 6 3 Tricorn protease PDZ domain Histone_H2A_C PF16211.3 MSTRG.17993.2_1 - 2.3e-15 55.9 0.0 4.1e-15 55.1 0.0 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.22 MSTRG.17993.2_1 - 1.6e-13 51.1 0.0 2.5e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 MSTRG.17993.2_1 - 6.4e-08 32.6 0.0 9.3e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Mito_carr PF00153.25 MSTRG.24601.1_3 - 5.3e-72 237.7 0.8 7.6e-24 83.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein TSP_C PF05735.10 MSTRG.7707.1_2 - 3.5e-95 317.5 0.8 5.3e-95 316.9 0.8 1.3 1 0 0 1 1 1 1 Thrombospondin C-terminal region TSP_3 PF02412.16 MSTRG.7707.1_2 - 1.9e-59 196.9 127.9 8.1e-12 44.5 8.1 9.9 7 2 2 9 9 9 8 Thrombospondin type 3 repeat TSP_1 PF00090.17 MSTRG.7707.1_2 - 3.2e-37 126.4 64.7 1.5e-15 57.0 9.3 4.6 5 0 0 5 5 5 3 Thrombospondin type 1 domain VWC PF00093.16 MSTRG.7707.1_2 - 3.8e-12 46.2 17.8 3.8e-12 46.2 17.8 5.9 3 2 0 3 3 3 1 von Willebrand factor type C domain EGF_3 PF12947.5 MSTRG.7707.1_2 - 1.3e-07 31.6 7.5 1.3e-07 31.6 7.5 6.0 6 0 0 6 6 6 1 EGF domain EGF_CA PF07645.13 MSTRG.7707.1_2 - 0.00013 21.9 3.6 0.00013 21.9 3.6 5.1 4 0 0 4 4 4 2 Calcium-binding EGF domain cEGF PF12662.5 MSTRG.7707.1_2 - 0.00014 21.6 0.8 0.00014 21.6 0.8 4.4 4 0 0 4 4 4 2 Complement Clr-like EGF-like Laminin_G_3 PF13385.4 MSTRG.7707.1_2 - 0.0055 16.7 1.2 0.03 14.4 0.1 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.22 MSTRG.7707.1_2 - 0.043 14.3 0.1 0.093 13.2 0.1 1.5 1 0 0 1 1 1 0 Laminin G domain UL73_N PF12522.6 MSTRG.7707.1_3 - 2.7 7.7 11.0 0.18 11.5 3.1 3.1 3 0 0 3 3 3 0 Cytomegalovirus glycoprotein N terminal bZIP_1 PF00170.19 MSTRG.4985.1_1 - 5.9e-10 39.0 11.8 5.9e-10 39.0 11.8 1.7 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.13 MSTRG.4985.1_1 - 1.4e-08 34.5 14.5 1.4e-08 34.5 14.5 2.2 2 1 1 3 3 3 1 Basic region leucine zipper bZIP_Maf PF03131.15 MSTRG.4985.1_1 - 1.9e-05 25.0 10.7 4.1e-05 23.9 10.7 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor DUF737 PF05300.9 MSTRG.4985.1_1 - 0.026 14.8 0.1 0.026 14.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF737) Atg14 PF10186.7 MSTRG.4985.1_1 - 0.029 13.3 8.2 0.045 12.7 8.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF972 PF06156.11 MSTRG.4985.1_1 - 1.4 9.5 9.5 6 7.4 8.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF2345 PF10106.7 MSTRG.19247.1_1 - 0.0009 19.0 6.4 0.085 12.6 0.2 3.2 1 1 2 3 3 3 2 Uncharacterized protein conserved in bacteria (DUF2345) DUF4816 PF16086.3 MSTRG.19247.1_1 - 0.12 12.3 29.2 0.89 9.5 1.3 5.1 2 2 1 4 4 4 0 Domain of unknown function (DUF4816) Collagen PF01391.16 MSTRG.19247.1_2 - 7e-10 38.4 108.5 1.2e-07 31.2 42.3 5.8 1 1 2 3 3 3 2 Collagen triple helix repeat (20 copies) Kelch_2 PF07646.13 MSTRG.19247.1_3 - 0.1 12.5 0.5 0.24 11.3 0.5 1.5 1 0 0 1 1 1 0 Kelch motif CAAP1 PF15335.4 MSTRG.19247.1_3 - 0.41 11.1 7.3 4.8 7.7 0.6 3.4 3 0 0 3 3 3 0 Caspase activity and apoptosis inhibitor 1 Catalase-rel PF06628.10 MSTRG.19247.1_3 - 9.8 6.3 19.6 3.2 7.9 1.5 4.4 4 1 0 4 4 4 0 Catalase-related immune-responsive TPR_2 PF07719.15 MSTRG.8890.1_3 - 1.9e-07 30.5 9.1 5.9e-06 25.9 0.4 3.0 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.8890.1_3 - 8.9e-06 25.2 12.5 9e-06 25.2 0.3 3.7 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.8890.1_3 - 0.0024 18.4 0.0 0.061 13.9 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.8890.1_3 - 0.0036 17.4 2.4 0.045 13.9 0.1 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.8890.1_3 - 0.0048 17.3 1.2 0.02 15.4 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.8890.1_3 - 0.014 15.2 1.3 2.3 8.3 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat CAF1 PF04857.18 MSTRG.8890.1_3 - 0.02 14.0 0.4 0.024 13.7 0.4 1.1 1 0 0 1 1 1 0 CAF1 family ribonuclease ANAPC3 PF12895.5 MSTRG.8890.1_3 - 0.02 14.9 0.5 0.02 14.9 0.5 3.2 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.4 MSTRG.8890.1_3 - 0.038 14.7 0.0 0.17 12.7 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.8890.1_3 - 0.094 13.1 0.1 0.51 10.7 0.0 2.1 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.8890.1_3 - 0.26 11.6 1.7 0.42 11.0 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 MSTRG.8890.1_3 - 0.27 11.2 9.2 0.21 11.5 0.5 3.2 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.8890.1_3 - 0.69 9.7 2.7 3.3 7.6 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat E1_dh PF00676.18 MSTRG.9431.1_1 - 3.2e-121 403.8 0.0 4e-121 403.4 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.19 MSTRG.9431.1_1 - 0.00016 21.3 0.3 0.00031 20.4 0.3 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.4 MSTRG.9431.1_1 - 0.0013 17.9 0.0 0.0021 17.2 0.0 1.2 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase SNF2_N PF00176.21 MSTRG.8998.2_3 - 2e-81 273.3 0.0 2.8e-81 272.8 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.9 MSTRG.8998.2_3 - 2e-17 62.8 0.0 5.3e-17 61.4 0.0 1.7 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.29 MSTRG.8998.2_3 - 5.5e-16 58.8 0.0 3.9e-15 56.0 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.4 MSTRG.8998.2_3 - 5.7e-09 35.6 7.8 1.3e-08 34.5 7.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 MSTRG.8998.2_3 - 5e-08 32.5 8.1 1.2e-07 31.3 8.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.8998.2_3 - 8e-07 29.1 8.8 2.1e-06 27.8 8.8 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.23 MSTRG.8998.2_3 - 8.9e-07 28.5 8.1 2e-06 27.4 8.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.8998.2_3 - 2.2e-06 27.5 5.6 5.7e-06 26.1 5.6 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.4 MSTRG.8998.2_3 - 8e-06 25.6 7.4 2e-05 24.3 7.4 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.4 MSTRG.8998.2_3 - 0.0001 22.3 8.8 0.00022 21.2 8.8 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING ResIII PF04851.13 MSTRG.8998.2_3 - 0.00016 21.6 0.0 0.028 14.3 0.0 2.7 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Prok-RING_4 PF14447.4 MSTRG.8998.2_3 - 0.00016 21.3 8.2 0.00035 20.2 8.2 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.5 MSTRG.8998.2_3 - 0.00031 20.6 0.9 0.00069 19.5 0.9 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.4 MSTRG.8998.2_3 - 0.00056 19.6 4.3 0.0016 18.1 4.3 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.5 MSTRG.8998.2_3 - 0.0082 16.3 3.5 0.03 14.5 3.2 2.1 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-Nse PF11789.6 MSTRG.8998.2_3 - 0.016 14.8 3.7 0.044 13.5 3.0 2.1 2 0 0 2 2 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.4 MSTRG.8998.2_3 - 0.044 13.4 2.6 0.1 12.2 2.6 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.3 MSTRG.8998.2_3 - 1.6 8.3 6.6 5.1 6.8 6.6 2.0 1 0 0 1 1 1 0 RING-like zinc finger DUF3872 PF12988.5 MSTRG.15677.1_1 - 0.09 12.4 0.1 0.14 11.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3872) Kelch_1 PF01344.23 MSTRG.15677.1_2 - 2.6e-46 154.8 18.2 3e-12 45.8 0.1 6.7 6 0 0 6 6 6 6 Kelch motif BACK PF07707.13 MSTRG.15677.1_2 - 4.2e-35 119.8 0.8 7.6e-35 119.0 0.8 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.29 MSTRG.15677.1_2 - 6.1e-28 97.1 0.6 2e-27 95.5 0.5 1.9 2 0 0 2 2 2 1 BTB/POZ domain Kelch_6 PF13964.4 MSTRG.15677.1_2 - 2.4e-27 94.2 5.8 0.0008 19.5 0.0 6.8 4 1 2 6 6 6 6 Kelch motif Kelch_3 PF13415.4 MSTRG.15677.1_2 - 1.2e-21 76.3 1.8 0.0069 16.5 0.0 6.6 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_2 PF07646.13 MSTRG.15677.1_2 - 3.4e-20 71.0 12.3 0.0001 22.0 0.2 6.5 6 1 0 6 6 6 5 Kelch motif Kelch_4 PF13418.4 MSTRG.15677.1_2 - 7.2e-17 61.0 0.8 0.00056 19.7 0.0 6.5 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.4 MSTRG.15677.1_2 - 7e-05 22.6 4.4 1.6 8.7 0.0 5.5 5 0 0 5 5 5 1 Kelch motif DUF3342 PF11822.6 MSTRG.15677.1_2 - 0.012 15.7 0.2 0.054 13.6 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) Ank_2 PF12796.5 MSTRG.22579.1_1 - 4.9e-23 81.4 16.2 3.1e-11 43.6 0.3 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.28 MSTRG.22579.1_1 - 3.5e-17 61.9 9.1 0.00015 21.9 0.0 5.6 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.4 MSTRG.22579.1_1 - 7.4e-17 59.6 4.5 0.0068 16.7 0.1 5.9 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.4 MSTRG.22579.1_1 - 4.3e-14 52.5 3.4 0.00069 20.0 0.1 4.4 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 MSTRG.22579.1_1 - 4.6e-12 45.8 6.5 5.4e-07 29.7 1.6 3.9 2 2 1 3 3 3 3 Ankyrin repeats (many copies) SAM_2 PF07647.15 MSTRG.22579.1_1 - 5.5e-07 29.5 3.6 7e-06 25.9 0.2 2.9 2 1 1 3 3 3 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 MSTRG.22579.1_1 - 3.1e-05 24.2 0.5 3.1e-05 24.2 0.5 2.7 2 1 1 3 3 3 1 SAM domain (Sterile alpha motif) zf-RING_2 PF13639.4 MSTRG.16087.1_3 - 7.7e-07 29.1 10.8 7.7e-07 29.1 10.8 2.1 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.4 MSTRG.16087.1_3 - 1.8e-06 27.6 9.5 1.8e-06 27.6 9.5 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 MSTRG.16087.1_3 - 5.2e-06 26.1 10.7 1.4e-05 24.7 10.7 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 MSTRG.16087.1_3 - 3.1e-05 23.6 10.6 0.00011 21.9 10.6 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.16087.1_3 - 6.1e-05 22.8 6.8 0.00016 21.4 6.8 1.8 1 0 0 1 1 1 1 RING-type zinc-finger CCDC85 PF10226.7 MSTRG.16087.1_3 - 0.001 18.7 8.8 0.001 18.7 8.8 2.8 2 1 1 3 3 3 1 CCDC85 family GAS PF13851.4 MSTRG.16087.1_3 - 0.0011 18.3 10.2 0.0011 18.3 10.2 2.0 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding zf-P11 PF03854.12 MSTRG.16087.1_3 - 0.0011 18.4 6.8 0.0011 18.4 6.8 2.4 3 0 0 3 3 2 1 P-11 zinc finger Spc7 PF08317.9 MSTRG.16087.1_3 - 0.0035 16.1 8.4 0.0035 16.1 8.4 1.9 2 0 0 2 2 2 1 Spc7 kinetochore protein ERM PF00769.17 MSTRG.16087.1_3 - 0.0053 16.5 3.9 0.0053 16.5 3.9 3.0 3 0 0 3 3 3 1 Ezrin/radixin/moesin family AAA_13 PF13166.4 MSTRG.16087.1_3 - 0.0055 15.3 8.6 0.01 14.4 8.6 1.3 1 0 0 1 1 1 1 AAA domain zf-rbx1 PF12678.5 MSTRG.16087.1_3 - 0.0059 16.7 8.3 0.02 15.0 8.3 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain Fib_alpha PF08702.8 MSTRG.16087.1_3 - 0.007 16.4 5.9 0.021 14.9 5.9 1.8 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family Cnn_1N PF07989.9 MSTRG.16087.1_3 - 0.0074 16.3 15.4 0.087 12.8 10.2 3.4 1 1 1 2 2 2 1 Centrosomin N-terminal motif 1 DivIC PF04977.13 MSTRG.16087.1_3 - 0.0074 15.9 14.8 0.4 10.4 0.4 3.4 3 0 0 3 3 3 2 Septum formation initiator CENP-H PF05837.10 MSTRG.16087.1_3 - 0.014 15.7 6.1 0.014 15.7 6.1 2.5 2 1 0 2 2 2 0 Centromere protein H (CENP-H) Reo_sigmaC PF04582.10 MSTRG.16087.1_3 - 0.034 13.4 1.3 0.29 10.4 0.0 2.1 2 0 0 2 2 2 0 Reovirus sigma C capsid protein zf-RING_5 PF14634.4 MSTRG.16087.1_3 - 0.045 13.6 9.5 0.13 12.1 9.5 1.9 1 0 0 1 1 1 0 zinc-RING finger domain HOOK PF05622.10 MSTRG.16087.1_3 - 0.056 11.5 18.3 0.17 9.9 17.9 1.6 1 1 0 1 1 1 0 HOOK protein ZapB PF06005.10 MSTRG.16087.1_3 - 0.058 13.7 19.4 0.73 10.2 3.8 3.4 3 0 0 3 3 3 0 Cell division protein ZapB DUF972 PF06156.11 MSTRG.16087.1_3 - 0.071 13.6 12.7 16 6.0 0.1 3.4 2 1 0 2 2 2 0 Protein of unknown function (DUF972) Shugoshin_N PF07558.9 MSTRG.16087.1_3 - 0.12 12.1 8.6 2.8 7.8 2.1 3.9 3 1 1 4 4 4 0 Shugoshin N-terminal coiled-coil region DUF1515 PF07439.9 MSTRG.16087.1_3 - 0.15 12.0 2.2 4.3 7.2 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) HALZ PF02183.16 MSTRG.16087.1_3 - 0.18 11.9 8.2 0.37 10.9 0.7 2.9 2 0 0 2 2 2 0 Homeobox associated leucine zipper Mod_r PF07200.11 MSTRG.16087.1_3 - 0.21 11.6 13.0 0.6 10.1 7.3 2.4 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein ADIP PF11559.6 MSTRG.16087.1_3 - 0.21 11.6 20.2 0.28 11.1 1.5 3.2 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Prok-RING_4 PF14447.4 MSTRG.16087.1_3 - 0.29 10.9 12.5 0.72 9.6 12.5 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 USP8_interact PF08941.8 MSTRG.16087.1_3 - 0.36 10.5 2.6 12 5.5 0.1 2.3 2 0 0 2 2 2 0 USP8 interacting FlgN PF05130.10 MSTRG.16087.1_3 - 0.44 10.9 10.1 0.13 12.6 4.5 2.3 2 0 0 2 2 2 0 FlgN protein Tropomyosin_1 PF12718.5 MSTRG.16087.1_3 - 0.55 10.2 16.2 0.44 10.6 0.8 2.3 2 0 0 2 2 2 0 Tropomyosin like ORF6C PF10552.7 MSTRG.16087.1_3 - 0.79 9.7 5.3 0.68 9.9 0.2 2.3 2 0 0 2 2 2 0 ORF6C domain TBPIP PF07106.11 MSTRG.16087.1_3 - 0.84 9.2 14.5 3.4 7.3 5.9 2.4 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF1664 PF07889.10 MSTRG.16087.1_3 - 1.1 9.1 3.3 3 7.7 3.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) SlyX PF04102.10 MSTRG.16087.1_3 - 1.3 9.5 17.7 0.07 13.6 3.9 3.5 3 1 0 3 3 3 0 SlyX IncA PF04156.12 MSTRG.16087.1_3 - 1.4 8.5 23.5 0.048 13.3 5.1 2.5 1 1 0 2 2 2 0 IncA protein TSC22 PF01166.16 MSTRG.16087.1_3 - 1.9 8.7 14.4 3.7 7.8 1.0 4.2 3 1 1 4 4 4 0 TSC-22/dip/bun family NRBF2 PF08961.8 MSTRG.16087.1_3 - 2.2 7.7 10.0 1.8 8.0 3.8 2.5 1 1 1 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator FlaC_arch PF05377.9 MSTRG.16087.1_3 - 2.3 8.6 11.4 5.5 7.3 0.2 3.5 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Wtap PF17098.3 MSTRG.16087.1_3 - 2.4 8.0 13.6 28 4.5 13.5 2.7 1 1 0 1 1 1 0 WTAP/Mum2p family DUF4407 PF14362.4 MSTRG.16087.1_3 - 2.4 7.3 6.9 4 6.6 6.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Lebercilin PF15619.4 MSTRG.16087.1_3 - 2.7 7.5 18.1 0.1 12.1 10.4 2.1 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease zf-RING_6 PF14835.4 MSTRG.16087.1_3 - 3.3 7.5 12.7 0.034 13.9 4.3 2.1 2 0 0 2 2 1 0 zf-RING of BARD1-type protein DUF2205 PF10224.7 MSTRG.16087.1_3 - 5 7.1 9.1 0.2 11.6 0.3 2.8 3 0 0 3 3 2 0 Predicted coiled-coil protein (DUF2205) BLOC1_2 PF10046.7 MSTRG.16087.1_3 - 6.2 7.1 11.8 6.5 7.0 6.0 3.1 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Exonuc_VII_L PF02601.13 MSTRG.16087.1_3 - 7.3 5.9 10.4 16 4.8 10.4 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit Atg14 PF10186.7 MSTRG.16087.1_3 - 7.9 5.3 19.5 31 3.4 18.8 2.1 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Spc29 PF17082.3 MSTRG.16087.1_3 - 8.8 6.0 10.2 0.91 9.2 1.6 2.3 1 1 1 2 2 2 0 Spindle Pole Component 29 Glycos_transf_2 PF00535.24 MSTRG.6313.1_1 - 8.4e-34 116.7 0.0 1.3e-33 116.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.20 MSTRG.6313.1_1 - 2.2e-09 37.5 3.0 6.6e-09 36.0 3.1 1.8 1 1 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.12 MSTRG.6313.1_1 - 0.00036 20.0 0.0 0.0008 18.9 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 MSTRG.6313.1_1 - 0.082 12.2 0.0 0.22 10.8 0.0 1.6 1 1 0 1 1 1 0 Glycosyltransferase like family 2 DUF3755 PF12579.6 MSTRG.26485.1_3 - 0.08 12.5 0.2 0.12 11.9 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3755) KR PF08659.8 MSTRG.4790.1_3 - 2.9e-48 164.0 0.0 8.6e-48 162.5 0.0 1.9 1 0 0 1 1 1 1 KR domain Thioesterase PF00975.18 MSTRG.4790.1_3 - 1.6e-38 133.0 0.0 2.8e-38 132.2 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain ADH_zinc_N PF00107.24 MSTRG.4790.1_3 - 2.8e-20 72.4 0.0 5.7e-20 71.4 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.4 MSTRG.4790.1_3 - 4e-15 56.9 0.0 1.4e-14 55.1 0.0 2.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PP-binding PF00550.23 MSTRG.4790.1_3 - 3.8e-09 36.7 0.4 8.5e-09 35.5 0.4 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site PS-DH PF14765.4 MSTRG.4790.1_3 - 1.5e-08 34.1 0.0 3.6e-08 32.9 0.0 1.6 1 1 0 1 1 1 1 Polyketide synthase dehydratase adh_short PF00106.23 MSTRG.4790.1_3 - 2.4e-07 30.3 0.0 6.6e-06 25.6 0.0 2.4 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.4 MSTRG.4790.1_3 - 0.0036 16.8 0.0 0.0073 15.8 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.13 MSTRG.4790.1_3 - 0.13 11.3 0.0 0.29 10.1 0.0 1.6 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Biopterin_H PF00351.19 MSTRG.22122.1_3 - 1.6e-30 106.1 0.2 1.8e-30 106.0 0.2 1.0 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase LRRFIP PF09738.7 MSTRG.14757.3_3 - 1.5e-83 280.6 20.3 1.5e-83 280.6 20.3 2.6 2 1 0 2 2 2 1 LRRFIP family TPR_MLP1_2 PF07926.10 MSTRG.14757.3_3 - 3.6e-06 26.9 38.0 0.0079 16.1 13.9 3.2 3 0 0 3 3 3 2 TPR/MLP1/MLP2-like protein AAA_13 PF13166.4 MSTRG.14757.3_3 - 0.0013 17.4 28.3 0.0055 15.3 6.2 2.1 2 0 0 2 2 2 2 AAA domain KASH_CCD PF14662.4 MSTRG.14757.3_3 - 0.0028 17.4 15.3 0.0028 17.4 15.3 3.0 2 1 1 3 3 3 2 Coiled-coil region of CCDC155 or KASH Fez1 PF06818.13 MSTRG.14757.3_3 - 0.011 16.1 37.2 0.013 15.9 17.1 2.3 1 1 1 2 2 2 0 Fez1 Syntaxin-6_N PF09177.9 MSTRG.14757.3_3 - 0.019 15.4 4.9 0.019 15.4 4.9 3.6 2 2 1 3 3 3 0 Syntaxin 6, N-terminal Spc7 PF08317.9 MSTRG.14757.3_3 - 0.039 12.7 42.6 0.082 11.6 14.3 3.2 2 1 1 3 3 3 0 Spc7 kinetochore protein DUF724 PF05266.12 MSTRG.14757.3_3 - 0.041 13.6 37.6 0.062 13.0 9.0 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF724) DUF3450 PF11932.6 MSTRG.14757.3_3 - 0.051 12.7 37.8 0.013 14.7 8.7 3.5 2 1 0 3 3 3 0 Protein of unknown function (DUF3450) Laminin_II PF06009.10 MSTRG.14757.3_3 - 0.064 13.1 26.4 0.045 13.6 7.7 3.7 3 1 0 3 3 3 0 Laminin Domain II MAD PF05557.11 MSTRG.14757.3_3 - 0.1 10.8 45.3 0.39 8.9 15.4 2.1 2 0 0 2 2 2 0 Mitotic checkpoint protein BRE1 PF08647.9 MSTRG.14757.3_3 - 0.22 11.5 42.9 0.16 12.0 14.2 3.4 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase DUF1664 PF07889.10 MSTRG.14757.3_3 - 0.22 11.4 32.2 2.7 7.9 0.3 4.4 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) Reo_sigmaC PF04582.10 MSTRG.14757.3_3 - 0.46 9.7 7.0 1.5 8.0 0.9 2.9 1 1 2 3 3 3 0 Reovirus sigma C capsid protein DUF1564 PF07600.9 MSTRG.14757.3_3 - 0.55 9.8 4.4 6.6 6.2 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1564) APG6 PF04111.10 MSTRG.14757.3_3 - 0.73 9.0 44.2 0.5 9.6 12.2 2.8 2 1 1 3 3 3 0 Autophagy protein Apg6 MscS_porin PF12795.5 MSTRG.14757.3_3 - 1.1 8.7 25.9 0.098 12.1 2.5 3.2 3 0 0 3 3 3 0 Mechanosensitive ion channel porin domain CALCOCO1 PF07888.9 MSTRG.14757.3_3 - 1.5 7.1 43.9 0.18 10.2 14.7 2.2 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like TACC PF05010.12 MSTRG.14757.3_3 - 1.8 8.1 44.0 0.13 11.9 14.9 3.2 2 1 1 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC) ATG16 PF08614.9 MSTRG.14757.3_3 - 2.3 8.2 46.8 1.3 9.1 10.6 3.8 3 1 1 4 4 4 0 Autophagy protein 16 (ATG16) Atg14 PF10186.7 MSTRG.14757.3_3 - 2.5 7.0 32.3 0.0087 15.0 3.7 3.0 2 1 0 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 TelA PF05816.9 MSTRG.14757.3_3 - 3.8 6.3 31.4 0.11 11.4 8.7 3.0 2 1 1 3 3 3 0 Toxic anion resistance protein (TelA) V_ATPase_I PF01496.17 MSTRG.14757.3_3 - 4.5 4.9 25.6 0.38 8.5 5.5 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF972 PF06156.11 MSTRG.14757.3_3 - 5.1 7.7 37.2 9.4 6.8 0.3 4.7 3 2 1 4 4 4 0 Protein of unknown function (DUF972) CENP-Q PF13094.4 MSTRG.14757.3_3 - 5.3 7.1 35.5 0.03 14.4 11.9 3.3 2 2 1 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit CHDCT2 PF08074.9 MSTRG.14757.3_3 - 5.6 7.0 18.6 2.2 8.3 4.3 3.1 2 2 1 3 3 3 0 CHDCT2 (NUC038) domain NPV_P10 PF05531.10 MSTRG.14757.3_3 - 7.1 7.0 14.4 0.87 10.0 0.5 3.8 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein FAM76 PF16046.3 MSTRG.14757.3_3 - 9.9 5.3 27.8 0.23 10.7 5.7 2.5 2 0 0 2 2 2 0 FAM76 protein RRM_1 PF00076.20 MSTRG.7891.2_1 - 9.3e-31 105.3 0.0 2.7e-16 59.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AZUL PF16558.3 MSTRG.7891.2_2 - 1.6 8.9 10.8 3.7 7.7 3.0 3.1 2 1 0 2 2 2 0 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A OST-HTH PF12872.5 MSTRG.21136.1_1 - 2e-09 37.1 0.1 0.0014 18.4 0.0 3.0 3 0 0 3 3 3 2 OST-HTH/LOTUS domain CAF1 PF04857.18 MSTRG.16012.1_2 - 9.5e-23 80.7 0.3 2.2e-12 46.7 0.0 2.5 2 1 0 2 2 2 2 CAF1 family ribonuclease Spectrin PF00435.19 MSTRG.19995.1_1 - 1.1e-15 57.9 32.3 5.7e-06 26.6 6.6 5.3 4 1 1 5 5 5 3 Spectrin repeat PilJ PF13675.4 MSTRG.19995.1_1 - 0.011 15.6 0.3 0.011 15.6 0.3 4.4 4 2 1 5 5 5 0 Type IV pili methyl-accepting chemotaxis transducer N-term Orthopox_A5L PF06193.9 MSTRG.19995.1_1 - 0.029 13.7 0.5 0.063 12.6 0.4 1.6 1 1 0 1 1 1 0 Orthopoxvirus A5L protein-like DUF641 PF04859.10 MSTRG.19995.1_1 - 0.038 14.2 0.2 0.038 14.2 0.2 3.9 3 1 1 4 4 4 0 Plant protein of unknown function (DUF641) DUF2270 PF10028.7 MSTRG.19995.1_1 - 0.1 12.0 1.0 0.2 11.1 1.0 1.4 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2270) Spore_III_AB PF09548.8 MSTRG.19995.1_1 - 0.36 10.8 10.3 0.18 11.7 4.9 2.8 2 1 1 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) Syntaxin_2 PF14523.4 MSTRG.19995.1_1 - 0.49 10.7 14.7 0.071 13.4 3.9 3.8 1 1 1 2 2 2 0 Syntaxin-like protein DUF948 PF06103.9 MSTRG.19995.1_1 - 0.62 10.2 6.2 2.4 8.4 0.4 3.9 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Baculo_PEP_C PF04513.10 MSTRG.19995.1_1 - 1.1 9.1 8.3 1 9.3 0.3 3.5 2 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Reo_sigmaC PF04582.10 MSTRG.19995.1_1 - 4.8 6.3 10.6 0.59 9.3 1.3 2.8 1 1 3 4 4 4 0 Reovirus sigma C capsid protein DUF3037 PF11236.6 MSTRG.19995.1_1 - 7.4 6.9 10.4 22 5.4 0.1 3.9 3 1 0 3 3 3 0 Protein of unknown function (DUF3037) DUF4787 PF16029.3 MSTRG.3001.1_3 - 0.0077 16.1 0.2 0.016 15.1 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4787) Pkinase PF00069.23 MSTRG.7643.2_1 - 7.9e-55 185.9 0.0 1.3e-54 185.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.7643.2_1 - 6.7e-38 130.3 0.0 1.2e-37 129.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 MSTRG.7643.2_1 - 0.0008 18.7 0.0 0.0017 17.6 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 MSTRG.7643.2_1 - 0.013 14.7 0.1 0.083 12.1 0.0 2.0 2 0 0 2 2 2 0 Kinase-like YrbL-PhoP_reg PF10707.7 MSTRG.7643.2_1 - 0.091 12.1 0.1 0.22 10.9 0.0 1.6 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL IKKbetaNEMObind PF12179.6 MSTRG.7643.2_3 - 0.00034 20.4 0.9 0.00068 19.5 0.9 1.5 1 0 0 1 1 1 1 I-kappa-kinase-beta NEMO binding domain C2 PF00168.28 MSTRG.19439.1_1 - 9.2e-24 83.6 0.1 1.4e-23 83.0 0.1 1.3 1 0 0 1 1 1 1 C2 domain DUF3070 PF11270.6 MSTRG.19439.1_1 - 1 9.5 4.0 0.35 11.0 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3070) FERM_f0 PF16511.3 MSTRG.2150.1_3 - 2.8e-39 133.1 0.1 7.8e-35 118.9 0.0 3.2 3 0 0 3 3 3 2 N-terminal or F0 domain of Talin-head FERM FERM_M PF00373.16 MSTRG.2150.1_3 - 1.6e-26 92.9 0.0 2.9e-26 92.1 0.0 1.4 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.8 MSTRG.2150.1_3 - 1.4e-24 85.7 0.5 1.6e-21 75.8 0.6 3.0 2 0 0 2 2 2 2 FERM N-terminal domain IRS PF02174.15 MSTRG.2150.1_3 - 5.9e-05 22.8 0.0 0.00013 21.7 0.0 1.6 1 0 0 1 1 1 1 PTB domain (IRS-1 type) DUF1013 PF06242.9 MSTRG.2150.1_3 - 0.0024 17.8 0.1 0.22 11.4 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1013) ACBP PF00887.17 MSTRG.2150.1_3 - 0.0028 17.7 0.0 0.0069 16.5 0.0 1.6 1 0 0 1 1 1 1 Acyl CoA binding protein Myosin_TH1 PF06017.11 MSTRG.2150.1_3 - 0.03 13.9 0.3 0.093 12.3 0.3 1.9 1 1 0 1 1 1 0 Unconventional myosin tail, actin- and lipid-binding ubiquitin PF00240.21 MSTRG.2150.1_3 - 0.035 13.7 0.1 8.7 6.0 0.0 2.9 2 0 0 2 2 2 0 Ubiquitin family eRF1_3 PF03465.13 MSTRG.2150.1_3 - 0.07 13.5 0.0 0.43 10.9 0.0 2.3 2 1 0 2 2 2 0 eRF1 domain 3 RA PF00788.21 MSTRG.2150.1_3 - 0.071 13.6 0.1 0.22 12.1 0.1 1.8 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain SDF PF00375.16 MSTRG.8995.1_1 - 1.3e-13 50.7 2.9 1.6e-13 50.3 2.9 1.1 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family DUF3480 PF11979.6 MSTRG.24990.2_2 - 1.5e-171 570.1 0.0 2e-171 569.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3480) SARA PF11409.6 MSTRG.24990.2_2 - 3.3e-19 68.7 10.5 1.3e-18 66.8 10.5 2.1 1 0 0 1 1 1 1 Smad anchor for receptor activation (SARA) FYVE PF01363.19 MSTRG.24990.2_2 - 2.7e-17 62.5 14.2 2.7e-17 62.5 14.2 2.1 2 0 0 2 2 2 1 FYVE zinc finger DUF3313 PF11769.6 MSTRG.24990.2_2 - 0.074 12.8 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3313) RIO1 PF01163.20 MSTRG.6784.1_2 - 2.2e-70 236.0 0.1 4.3e-70 235.0 0.1 1.4 1 0 0 1 1 1 1 RIO1 family Pkinase PF00069.23 MSTRG.6784.1_2 - 0.0012 18.1 0.3 0.0021 17.4 0.3 1.3 1 0 0 1 1 1 1 Protein kinase domain TMEM219 PF14940.4 MSTRG.5639.2_2 - 1e-29 103.6 3.5 1.1e-28 100.4 3.5 2.0 1 1 0 1 1 1 1 Transmembrane 219 Aida_N PF08910.8 MSTRG.24967.5_2 - 0.33 11.2 6.6 0.086 13.1 1.6 2.5 1 1 1 3 3 3 0 Aida N-terminus Herpes_BLRF2 PF05812.10 MSTRG.24967.5_3 - 2.4 8.2 11.3 30 4.7 0.1 4.2 4 0 0 4 4 4 0 Herpesvirus BLRF2 protein AZUL PF16558.3 MSTRG.22093.1_2 - 0.021 14.9 0.1 0.037 14.1 0.1 1.4 1 0 0 1 1 1 0 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A SR1P PF13790.4 MSTRG.10986.1_1 - 0.18 11.8 0.5 0.35 10.9 0.0 1.6 2 0 0 2 2 2 0 SR1 protein dsrm PF00035.24 MSTRG.17105.1_2 - 0.0014 19.2 0.0 0.0025 18.3 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif UMP1 PF05348.9 MSTRG.12298.1_2 - 0.032 14.3 0.1 0.056 13.5 0.1 1.3 1 0 0 1 1 1 0 Proteasome maturation factor UMP1 BIRC6 PF12356.6 MSTRG.14585.3_3 - 1.3e-69 233.0 1.8 2.6e-69 232.0 1.8 1.6 1 0 0 1 1 1 1 Baculoviral IAP repeat-containing protein 6 UQ_con PF00179.24 MSTRG.14585.3_3 - 7.4e-31 106.5 0.0 1.6e-30 105.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.11 MSTRG.14585.3_3 - 7.2e-05 22.5 0.0 0.00017 21.3 0.0 1.6 1 0 0 1 1 1 1 UEV domain RWD PF05773.20 MSTRG.14585.3_3 - 0.11 12.6 0.0 0.37 11.0 0.0 1.8 1 0 0 1 1 1 0 RWD domain Abhydrolase_2 PF02230.14 MSTRG.7872.1_2 - 5.3e-80 268.2 0.1 7.1e-80 267.7 0.1 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase DLH PF01738.16 MSTRG.7872.1_2 - 7e-07 28.9 0.0 1.6e-06 27.7 0.0 1.5 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.11 MSTRG.7872.1_2 - 2.2e-05 24.2 0.0 3.7e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold FSH1 PF03959.11 MSTRG.7872.1_2 - 0.00015 21.4 0.0 0.00036 20.1 0.0 1.6 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Hydrolase_4 PF12146.6 MSTRG.7872.1_2 - 0.00035 19.8 0.0 0.11 11.6 0.0 2.8 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.19 MSTRG.7872.1_2 - 0.00055 19.3 0.0 0.11 11.8 0.0 2.3 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_6 PF12697.5 MSTRG.7872.1_2 - 0.0017 18.9 0.0 0.0023 18.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2974 PF11187.6 MSTRG.7872.1_2 - 0.0024 17.3 0.0 0.0039 16.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_1 PF00561.18 MSTRG.7872.1_2 - 0.0049 16.4 0.6 0.039 13.4 0.6 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF2920 PF11144.6 MSTRG.7872.1_2 - 0.023 13.7 0.0 1.7 7.6 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2920) P2X_receptor PF00864.17 MSTRG.22806.3_3 - 1.3e-114 383.0 0.3 1.6e-114 382.7 0.3 1.0 1 0 0 1 1 1 1 ATP P2X receptor WAP PF00095.19 MSTRG.22806.3_3 - 0.045 14.0 1.8 0.045 14.0 1.8 2.0 2 0 0 2 2 2 0 WAP-type (Whey Acidic Protein) 'four-disulfide core' CarbpepA_inh PF02977.13 MSTRG.22806.3_3 - 6.3 6.5 7.7 0.38 10.5 2.1 1.8 2 0 0 2 2 2 0 Carboxypeptidase A inhibitor DUF4570 PF15134.4 MSTRG.6019.1_2 - 1.1e-30 105.7 2.5 1.6e-30 105.2 2.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4570) NYD-SP28_assoc PF14775.4 MSTRG.6019.1_2 - 0.35 10.9 3.2 0.22 11.5 0.6 2.0 2 0 0 2 2 2 0 Sperm tail C-terminal domain F-box-like PF12937.5 MSTRG.16751.1_2 - 6.7e-14 51.4 0.1 3.5e-13 49.1 0.1 2.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 MSTRG.16751.1_2 - 3.7e-08 32.9 0.0 3.7e-08 32.9 0.0 2.2 2 0 0 2 2 2 1 F-box domain WD40 PF00400.30 MSTRG.16751.1_2 - 0.00023 21.7 13.6 6.6 7.7 0.1 6.2 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.16751.1_2 - 0.0035 17.5 0.1 5.8 7.2 0.0 4.0 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain RhoGAP PF00620.25 MSTRG.13115.2_1 - 7.8e-27 93.8 0.0 1.7e-26 92.7 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain MyTH4 PF00784.15 MSTRG.13115.2_1 - 4.4e-26 91.3 0.2 3.5e-24 85.2 0.2 2.6 1 1 0 1 1 1 1 MyTH4 domain WW PF00397.24 MSTRG.13115.2_1 - 1.4e-08 34.4 5.2 1.9e-06 27.6 3.9 2.6 2 0 0 2 2 2 2 WW domain MyTH4 PF00784.15 MSTRG.16361.3_2 - 1.1e-47 160.7 7.1 3.7e-26 91.6 0.0 3.2 3 0 0 3 3 3 2 MyTH4 domain SH3_2 PF07653.15 MSTRG.16361.3_2 - 1.5e-08 34.0 0.0 2.8e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 MSTRG.16361.3_2 - 2.7e-06 27.0 0.0 6.6e-06 25.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain FERM_M PF00373.16 MSTRG.16361.3_2 - 0.00098 19.4 0.2 0.00098 19.4 0.2 2.7 3 1 0 3 3 3 1 FERM central domain SH3_1 PF00018.26 MSTRG.16361.3_2 - 0.0032 16.9 0.0 0.012 15.0 0.0 2.0 2 0 0 2 2 2 1 SH3 domain U79_P34 PF03064.14 MSTRG.16361.3_2 - 0.9 8.7 8.3 2.1 7.5 8.3 1.5 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Pkinase PF00069.23 MSTRG.8997.1_3 - 5.5e-73 245.4 0.0 7.3e-73 245.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.8997.1_3 - 5.3e-47 160.2 0.0 7.6e-47 159.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 MSTRG.8997.1_3 - 5.1e-25 87.5 0.1 9.6e-25 86.6 0.1 1.5 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 MSTRG.8997.1_3 - 2.3e-07 30.3 0.1 0.0002 20.7 0.1 2.2 1 1 1 2 2 2 2 Kinase-like Kdo PF06293.12 MSTRG.8997.1_3 - 0.0086 15.3 0.0 0.017 14.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 MSTRG.8997.1_3 - 0.01 15.7 0.0 0.27 11.0 0.2 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family MRI PF15325.4 MSTRG.8997.1_3 - 0.69 11.0 4.8 0.24 12.5 0.4 2.4 2 0 0 2 2 2 0 Modulator of retrovirus infection BTB PF00651.29 MSTRG.22661.1_1 - 1.2e-19 70.4 0.1 2.2e-19 69.6 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 MSTRG.22661.1_1 - 0.0023 18.2 20.8 0.016 15.5 4.5 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_2 PF12756.5 MSTRG.22661.1_1 - 0.005 17.0 1.9 2.6 8.3 0.0 2.4 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2HE PF16278.3 MSTRG.22661.1_1 - 0.016 15.6 1.6 1.2 9.6 0.1 2.4 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_4 PF13894.4 MSTRG.22661.1_1 - 0.15 12.8 17.3 0.86 10.5 2.3 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_4 PF13894.4 MSTRG.22661.1_2 - 0.03 15.0 1.4 0.16 12.8 0.1 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.24 MSTRG.22661.1_2 - 0.07 13.5 0.8 0.34 11.3 0.8 2.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type Laminin_N PF00055.15 MSTRG.4535.1_2 - 4.9e-81 271.6 0.1 5.8e-81 271.4 0.1 1.1 1 0 0 1 1 1 1 Laminin N-terminal (Domain VI) F5_F8_type_C PF00754.23 MSTRG.4535.1_2 - 0.0002 21.4 0.0 0.00031 20.7 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain Arm PF00514.21 MSTRG.15780.7_2 - 7e-28 95.6 12.0 1.9e-07 30.8 0.0 6.9 9 0 0 9 9 9 4 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.4 MSTRG.15780.7_2 - 4.4e-07 30.1 0.5 0.36 11.2 0.0 4.9 5 0 0 5 5 5 2 HEAT-like repeat HEAT_2 PF13646.4 MSTRG.15780.7_2 - 3.9e-05 23.8 0.1 0.083 13.2 0.0 2.6 2 0 0 2 2 2 2 HEAT repeats HEAT PF02985.20 MSTRG.15780.7_2 - 5.6e-05 22.9 0.1 1.2 9.5 0.0 3.8 3 0 0 3 3 3 2 HEAT repeat Atx10homo_assoc PF09759.7 MSTRG.15780.7_2 - 0.0061 16.5 0.1 0.41 10.6 0.0 2.9 3 0 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain Heme_oxygenase PF01126.18 MSTRG.12925.1_3 - 2e-77 259.5 1.5 2.7e-77 259.1 1.5 1.2 1 0 0 1 1 1 1 Heme oxygenase EF-hand_7 PF13499.4 MSTRG.19760.1_2 - 1.7e-18 66.7 2.9 3.1e-09 37.1 0.0 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.19760.1_2 - 1.5e-15 55.6 2.0 3.5e-05 23.3 0.0 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.30 MSTRG.19760.1_2 - 4.9e-15 53.7 3.9 9.1e-07 27.9 0.0 4.3 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.4 MSTRG.19760.1_2 - 3.1e-11 42.1 1.4 0.0017 17.6 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.4 MSTRG.19760.1_2 - 8.5e-10 38.1 1.4 6.8e-06 25.6 0.1 3.1 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_4 PF12763.5 MSTRG.19760.1_2 - 0.00025 20.8 0.4 0.025 14.4 0.0 2.9 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 MSTRG.19760.1_2 - 0.00035 20.7 0.3 0.3 11.3 0.0 2.4 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.9 MSTRG.19760.1_2 - 0.00086 20.0 0.8 1.4 9.7 0.0 2.8 1 1 2 3 3 3 2 EF-hand domain EF-hand_10 PF14788.4 MSTRG.19760.1_2 - 0.0094 15.7 0.9 0.6 9.9 0.0 3.5 4 0 0 4 4 4 1 EF hand WD40 PF00400.30 MSTRG.17624.1_3 - 4.4e-23 81.0 11.3 5.6e-05 23.7 0.0 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.17624.1_3 - 1.5e-11 44.3 0.0 0.012 15.7 0.0 5.0 2 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 MSTRG.17624.1_3 - 2.7e-05 23.2 0.6 0.024 13.5 0.1 3.6 2 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.9 MSTRG.17624.1_3 - 0.00055 19.7 0.0 0.77 9.5 0.0 3.6 1 1 3 4 4 4 1 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.4 MSTRG.17624.1_3 - 0.056 12.6 0.0 0.38 9.9 0.0 2.1 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Mito_carr PF00153.25 MSTRG.25392.1_2 - 8.5e-72 237.0 1.6 6.8e-26 89.9 0.1 3.7 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.30 MSTRG.25392.1_2 - 4.4e-09 35.1 3.1 0.087 12.3 0.1 5.0 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.4 MSTRG.25392.1_2 - 3e-08 32.8 1.4 0.039 13.8 0.1 5.1 5 0 0 5 5 5 3 EF-hand domain EF-hand_7 PF13499.4 MSTRG.25392.1_2 - 5.9e-05 23.3 1.8 0.2 12.0 0.0 3.5 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.25392.1_2 - 9.7e-05 21.6 0.4 0.22 11.0 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.4 MSTRG.25392.1_2 - 0.00045 19.8 1.1 0.58 9.8 0.0 4.1 5 0 0 5 5 5 2 EF-hand domain pair ABC2_membrane_3 PF12698.5 MSTRG.5604.1_3 - 8.7e-58 195.9 35.7 8.6e-42 143.3 11.9 2.3 2 0 0 2 2 2 2 ABC-2 family transporter protein ABC_tran PF00005.25 MSTRG.5604.1_3 - 1.2e-54 184.4 0.0 8.3e-30 103.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.4 MSTRG.5604.1_3 - 1.2e-17 64.6 3.9 3.7e-07 30.1 0.0 4.3 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.4 MSTRG.5604.1_3 - 5.5e-05 23.7 0.0 0.21 12.2 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4162) AAA_23 PF13476.4 MSTRG.5604.1_3 - 0.00013 22.5 3.8 0.013 15.9 0.2 2.5 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.4 MSTRG.5604.1_3 - 0.0045 16.5 2.9 0.12 12.0 0.3 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF258 PF03193.14 MSTRG.5604.1_3 - 0.015 15.1 0.1 2.9 7.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function, DUF258 SRP54 PF00448.20 MSTRG.5604.1_3 - 0.053 13.0 4.2 1.7 8.1 0.2 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_15 PF13175.4 MSTRG.5604.1_3 - 0.067 12.7 0.0 0.5 9.8 0.0 2.4 3 0 0 3 3 3 0 AAA ATPase domain SMC_N PF02463.17 MSTRG.5604.1_3 - 0.12 11.6 0.6 14 4.9 0.0 2.8 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain MukB PF04310.10 MSTRG.5604.1_3 - 0.21 11.2 1.3 1.1 8.9 0.1 2.2 2 0 0 2 2 2 0 MukB N-terminal AAA_30 PF13604.4 MSTRG.5604.1_3 - 0.52 9.9 1.5 9.4 5.8 0.1 2.3 2 0 0 2 2 2 0 AAA domain ABC2_membrane_2 PF12679.5 MSTRG.5604.1_3 - 4.3 6.4 14.6 0.098 11.8 7.0 2.0 2 0 0 2 2 2 0 ABC-2 family transporter protein DUF3663 PF12404.6 MSTRG.25349.1_3 - 2.1 8.3 5.3 5.8 6.9 0.2 3.1 4 0 0 4 4 4 0 Peptidase CNH PF00780.20 MSTRG.25659.1_1 - 7.4e-74 248.7 0.0 1.3e-73 247.9 0.0 1.4 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.23 MSTRG.25659.1_1 - 2.5e-56 190.8 0.0 5.1e-56 189.8 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.25659.1_1 - 3.3e-30 105.1 0.0 6e-30 104.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DMPK_coil PF08826.8 MSTRG.25659.1_1 - 2.1e-26 91.7 11.1 2.1e-26 91.7 11.1 7.1 6 2 1 7 7 4 2 DMPK coiled coil domain like KELK PF15796.3 MSTRG.25659.1_1 - 2.8e-24 85.3 14.6 2.8e-24 85.3 14.6 7.1 5 2 2 7 7 6 1 KELK-motif containing domain of MRCK Ser/Thr protein kinase C1_1 PF00130.20 MSTRG.25659.1_1 - 2.5e-11 43.1 8.8 5.5e-11 42.1 8.8 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.4 MSTRG.25659.1_1 - 2.6e-07 30.1 0.0 5.4e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_C PF00433.22 MSTRG.25659.1_1 - 1.6e-05 25.4 2.2 5.1e-05 23.7 2.2 2.0 1 0 0 1 1 1 1 Protein kinase C terminal domain PH PF00169.27 MSTRG.25659.1_1 - 0.00014 22.1 0.0 0.00065 20.0 0.0 2.2 1 0 0 1 1 1 1 PH domain PBD PF00786.26 MSTRG.25659.1_1 - 0.001 19.3 0.4 0.04 14.2 0.1 3.1 3 0 0 3 3 3 1 P21-Rho-binding domain Seadorna_VP7 PF07387.9 MSTRG.25659.1_1 - 0.092 11.6 0.1 0.19 10.6 0.1 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 C1_2 PF03107.14 MSTRG.25659.1_1 - 5.1 7.3 7.1 15 5.9 7.1 1.8 1 0 0 1 1 1 0 C1 domain FIIND PF13553.4 MSTRG.7481.1_2 - 9.5e-28 97.1 0.0 1e-27 97.0 0.0 1.0 1 0 0 1 1 1 1 Function to find ATP-synt_C PF00137.19 MSTRG.15591.1_2 - 5e-26 90.7 33.4 8.5e-13 48.3 12.5 2.5 2 0 0 2 2 2 2 ATP synthase subunit C Ras PF00071.20 MSTRG.10010.1_1 - 5.7e-55 185.2 0.0 8e-55 184.7 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.10010.1_1 - 6.7e-19 68.2 0.0 1.3e-18 67.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.10010.1_1 - 3.7e-09 36.1 0.0 5.9e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 MSTRG.10010.1_1 - 2.3e-05 24.2 0.2 0.021 14.6 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 MSTRG.10010.1_1 - 0.00018 20.9 0.0 0.00058 19.3 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 MSTRG.10010.1_1 - 0.0024 17.8 0.0 0.0034 17.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.3 MSTRG.10010.1_1 - 0.086 12.8 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain 2-oxogl_dehyd_N PF16078.3 MSTRG.5339.1_2 - 0.074 12.5 0.6 0.13 11.7 0.6 1.3 1 0 0 1 1 1 0 2-oxoglutarate dehydrogenase N-terminus SapB_1 PF05184.13 MSTRG.7744.1_2 - 2e-39 133.0 30.6 3.6e-12 45.9 3.7 4.8 4 0 0 4 4 4 4 Saposin-like type B, region 1 SapB_2 PF03489.15 MSTRG.7744.1_2 - 1.8e-35 120.6 29.1 7.9e-10 38.6 0.6 5.3 5 0 0 5 5 5 4 Saposin-like type B, region 2 SapA PF02199.13 MSTRG.7744.1_2 - 7.6e-31 105.8 26.4 1.3e-16 60.3 7.7 4.2 4 0 0 4 4 4 2 Saposin A-type domain HD_3 PF13023.4 MSTRG.7744.1_2 - 0.012 15.5 0.1 0.42 10.4 0.1 2.2 2 0 0 2 2 2 0 HD domain DUF4359 PF14271.4 MSTRG.7744.1_2 - 0.019 15.5 3.8 1.8 9.3 0.2 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4359) Cyclin_C PF02984.17 MSTRG.12930.2_2 - 4e-07 30.0 0.1 8.1e-07 29.0 0.1 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain Cyclin_N PF00134.21 MSTRG.12930.2_2 - 3.9e-05 23.3 0.1 6.8e-05 22.5 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain APG9 PF04109.14 MSTRG.8813.1_2 - 7e-09 35.2 0.3 9e-09 34.8 0.3 1.1 1 0 0 1 1 1 1 Autophagy protein Apg9 LEA_6 PF10714.7 MSTRG.8813.1_2 - 0.011 15.7 0.2 0.026 14.6 0.2 1.5 1 0 0 1 1 1 0 Late embryogenesis abundant protein 18 SMN PF06003.10 MSTRG.16942.1_2 - 1.1e-108 362.3 11.4 1.4e-108 362.0 11.4 1.1 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) TUDOR PF00567.22 MSTRG.16942.1_2 - 2.4e-06 27.4 0.1 4e-06 26.7 0.1 1.3 1 0 0 1 1 1 1 Tudor domain BUD22 PF09073.8 MSTRG.16942.1_2 - 0.0019 17.5 9.6 0.0028 16.9 9.6 1.1 1 0 0 1 1 1 1 BUD22 Kelch_3 PF13415.4 MSTRG.2213.2_2 - 7.6e-22 76.9 1.3 8.9e-07 28.9 0.1 5.1 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.4 MSTRG.2213.2_2 - 1.5e-19 69.4 0.3 5.8e-05 22.8 0.0 4.6 4 0 0 4 4 4 4 Kelch motif Kelch_4 PF13418.4 MSTRG.2213.2_2 - 2.9e-13 49.4 0.2 0.0029 17.4 0.0 4.9 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.4 MSTRG.2213.2_2 - 8.2e-13 48.0 1.7 0.0078 16.3 0.0 4.9 4 0 0 4 4 4 4 Kelch motif Kelch_1 PF01344.23 MSTRG.2213.2_2 - 1.1e-12 47.2 2.0 1.8e-05 24.1 0.0 4.4 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.13 MSTRG.2213.2_2 - 1.7e-10 40.3 3.0 0.01 15.7 0.1 4.7 4 0 0 4 4 4 4 Kelch motif fn3 PF00041.19 MSTRG.2213.2_2 - 1.8e-09 37.7 0.7 0.24 11.6 0.0 4.9 6 0 0 6 6 6 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 MSTRG.2213.2_2 - 0.016 15.7 0.1 2 8.9 0.0 3.2 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain Sds3 PF08598.9 MSTRG.14372.1_2 - 4.1e-25 88.9 1.1 5.8e-25 88.5 1.1 1.2 1 0 0 1 1 1 1 Sds3-like Phosducin PF02114.14 MSTRG.10692.1_3 - 2.3e-95 318.4 0.7 3.1e-95 318.0 0.7 1.1 1 0 0 1 1 1 1 Phosducin DAGK_cat PF00781.22 MSTRG.6267.1_1 - 4.7e-29 100.4 0.0 9.5e-29 99.4 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.20 MSTRG.6267.1_1 - 3e-13 49.3 29.2 4.9e-11 42.2 15.0 2.6 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) RRM_1 PF00076.20 MSTRG.23067.2_2 - 2.5e-35 120.0 0.1 1.1e-16 60.3 0.2 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.23067.2_2 - 1.2e-11 44.5 0.0 4.2e-06 26.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.4 MSTRG.23067.2_2 - 2e-05 24.3 0.1 0.015 15.1 0.1 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.4 MSTRG.23067.2_2 - 0.096 12.8 0.2 1.5 8.9 0.1 2.2 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Chorismate_bind PF00425.16 MSTRG.27294.2_1 - 0.024 14.1 0.9 0.77 9.1 0.0 2.3 2 0 0 2 2 2 0 chorismate binding enzyme Peroxin-13_N PF04088.11 MSTRG.14630.1_3 - 2.2e-45 154.3 0.2 4.9e-45 153.2 0.0 1.6 2 0 0 2 2 2 1 Peroxin 13, N-terminal region SH3_9 PF14604.4 MSTRG.14630.1_3 - 1.7e-10 40.5 0.0 2.8e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.14630.1_3 - 6.9e-08 31.8 0.0 1.2e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.14630.1_3 - 2.2e-05 23.9 0.0 3.5e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain XRN_N PF03159.16 MSTRG.7066.2_3 - 3.6e-95 317.8 0.0 6.6e-95 317.0 0.0 1.5 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus Mit_proteolip PF08039.9 MSTRG.19989.1_2 - 1.8e-10 40.8 2.1 2.5e-10 40.4 2.1 1.3 1 0 0 1 1 1 1 Mitochondrial proteolipid TMEM189_B_dmain PF10520.7 MSTRG.18515.1_3 - 6.2e-77 257.6 3.1 8.8e-77 257.1 3.1 1.2 1 0 0 1 1 1 1 B domain of TMEM189, localisation domain SUZ PF12752.5 MSTRG.6492.3_1 - 1e-12 48.5 4.5 6.6e-12 45.9 4.5 2.5 1 0 0 1 1 1 1 SUZ domain R3H PF01424.20 MSTRG.6492.3_1 - 1.5e-12 47.2 0.0 6.5e-12 45.1 0.0 2.2 1 0 0 1 1 1 1 R3H domain YqzM PF14141.4 MSTRG.10617.1_3 - 7.7 6.5 6.8 14 5.7 6.8 1.4 1 0 0 1 1 1 0 YqzM-like protein COX17 PF05051.11 MSTRG.24455.1_1 - 0.00018 21.6 0.8 0.00031 20.9 0.8 1.3 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) UCR_hinge PF02320.14 MSTRG.24455.1_1 - 0.033 14.3 1.0 0.19 11.8 0.5 2.1 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein Cmc1 PF08583.8 MSTRG.24455.1_1 - 0.047 13.6 2.0 0.19 11.6 2.0 1.9 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.11 MSTRG.24455.1_1 - 0.063 13.3 0.8 0.063 13.3 0.8 1.9 2 0 0 2 2 2 0 CHCH domain CX9C PF16860.3 MSTRG.24455.1_1 - 0.14 12.0 0.8 24 4.9 0.0 2.9 3 0 0 3 3 3 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, PRIMA1 PF16101.3 MSTRG.24455.1_2 - 0.031 14.2 7.1 0.031 14.2 7.1 2.2 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 CH PF00307.29 MSTRG.11974.2_3 - 4.2e-15 55.7 0.0 6.9e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 MSTRG.11974.2_3 - 0.0024 17.6 0.0 0.005 16.5 0.0 1.5 1 0 0 1 1 1 1 CAMSAP CH domain DivIVA PF05103.11 MSTRG.11974.2_3 - 0.1 12.5 3.4 0.18 11.7 3.4 1.3 1 0 0 1 1 1 0 DivIVA protein DUF2968 PF11180.6 MSTRG.11974.2_3 - 0.72 9.4 9.9 1.3 8.5 9.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Jnk-SapK_ap_N PF09744.7 MSTRG.11974.2_3 - 2 8.5 15.2 0.91 9.6 12.6 1.7 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Rootletin PF15035.4 MSTRG.11974.2_3 - 5.9 6.8 19.6 0.28 11.1 13.2 1.8 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion EF-hand_7 PF13499.4 MSTRG.10733.1_1 - 4.1e-12 46.2 0.1 1e-11 45.0 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 MSTRG.10733.1_1 - 1.7e-08 33.2 2.4 0.0018 17.6 0.0 3.9 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.4 MSTRG.10733.1_1 - 3.1e-07 29.9 0.8 0.0016 18.0 0.0 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.10733.1_1 - 2.4e-06 26.9 0.5 0.00014 21.4 0.1 3.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_4 PF12763.5 MSTRG.10733.1_1 - 0.00035 20.4 0.1 0.00074 19.3 0.1 1.5 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.4 MSTRG.10733.1_1 - 0.0087 15.4 0.1 0.024 14.0 0.1 1.8 1 0 0 1 1 1 1 EF hand p25-alpha PF05517.10 MSTRG.10733.1_1 - 0.32 11.0 3.8 34 4.4 0.0 3.0 2 1 1 3 3 3 0 p25-alpha EF_assoc_2 PF08356.10 MSTRG.10733.1_3 - 0.001 18.9 0.0 0.0022 17.8 0.0 1.4 1 0 0 1 1 1 1 EF hand associated EF-hand_7 PF13499.4 MSTRG.10733.1_3 - 0.021 15.2 0.0 0.041 14.2 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.30 MSTRG.10733.1_3 - 0.021 14.2 0.0 0.039 13.4 0.0 1.4 1 0 0 1 1 1 0 EF hand EF-hand_5 PF13202.4 MSTRG.10733.1_3 - 0.058 12.8 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 EF hand EF-hand_8 PF13833.4 MSTRG.10733.1_3 - 0.062 12.9 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair CH PF00307.29 MSTRG.20474.5_1 - 9.6e-41 138.3 1.1 7.9e-22 77.4 0.9 2.2 2 0 0 2 2 2 2 Calponin homology (CH) domain CH_2 PF06294.9 MSTRG.20474.5_1 - 0.00048 20.1 0.3 0.11 12.5 0.1 2.3 2 0 0 2 2 2 2 CH-like domain in sperm protein CAMSAP_CH PF11971.6 MSTRG.20474.5_1 - 0.048 13.4 0.1 3.5 7.4 0.1 2.4 2 0 0 2 2 2 0 CAMSAP CH domain Synaptobrevin PF00957.19 MSTRG.27380.1_1 - 1.8 8.3 5.2 3.4 7.4 5.2 1.5 1 0 0 1 1 1 0 Synaptobrevin OATP PF03137.18 MSTRG.14437.2_2 - 4.1e-175 583.0 12.4 5.2e-175 582.7 12.4 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 MSTRG.14437.2_2 - 2e-25 89.3 9.7 2e-25 89.3 9.7 2.8 3 1 0 3 3 3 2 Major Facilitator Superfamily Kazal_2 PF07648.13 MSTRG.14437.2_2 - 3.6e-07 30.1 0.7 1.1e-06 28.6 0.7 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 MSTRG.14437.2_2 - 0.00051 19.9 2.7 0.0016 18.3 2.7 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain MFS_1_like PF12832.5 MSTRG.14437.2_2 - 0.025 13.3 0.2 0.21 10.3 0.1 2.1 1 1 1 2 2 2 0 MFS_1 like family Pkinase PF00069.23 MSTRG.21614.1_1 - 1e-15 57.7 0.6 1.3e-15 57.4 0.6 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.21614.1_1 - 4e-09 36.0 0.1 4.8e-09 35.7 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase WD40 PF00400.30 MSTRG.5334.1_3 - 5.8e-15 55.3 7.8 8.3e-05 23.2 0.1 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.5334.1_3 - 4.6e-07 29.9 0.0 0.19 11.9 0.0 3.6 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 MSTRG.5334.1_3 - 0.014 14.6 0.0 0.023 13.9 0.0 1.3 1 0 0 1 1 1 0 WD40-like domain Herpes_gI PF01688.15 MSTRG.5334.1_3 - 0.11 12.3 0.8 0.29 10.9 0.3 1.9 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein I Nup160 PF11715.6 MSTRG.5334.1_3 - 0.15 10.5 0.0 0.22 9.9 0.0 1.2 1 0 0 1 1 1 0 Nucleoporin Nup120/160 V-set PF07686.15 MSTRG.10282.1_3 - 0.048 13.7 0.0 0.08 13.0 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin V-set domain I-set PF07679.14 MSTRG.10282.1_3 - 0.088 12.8 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin I-set domain 7tm_1 PF00001.19 MSTRG.6852.1_3 - 7.6e-56 189.2 3.6 9.9e-56 188.8 3.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 MSTRG.6852.1_3 - 5.8e-12 45.4 2.2 7.9e-12 45.0 2.2 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 MSTRG.6852.1_3 - 8.5e-07 28.5 2.7 1.2e-06 28.0 2.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.7 MSTRG.6852.1_3 - 0.00036 19.8 10.6 0.00048 19.4 10.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 MSTRG.6852.1_3 - 0.00049 19.8 8.7 0.00077 19.1 8.7 1.3 1 1 0 1 1 1 1 Olfactory receptor Gaa1 PF04114.12 MSTRG.6852.1_3 - 0.24 10.3 9.1 0.3 10.0 9.1 1.1 1 0 0 1 1 1 0 Gaa1-like, GPI transamidase component RasGEF PF00617.17 MSTRG.9109.1_2 - 5.8e-15 55.8 0.1 8.7e-15 55.2 0.1 1.3 1 0 0 1 1 1 1 RasGEF domain RRM_1 PF00076.20 MSTRG.16088.5_2 - 7.2e-11 41.6 0.0 1.4e-05 24.6 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 MSTRG.16088.5_2 - 3.6e-10 39.5 0.0 7.7e-05 22.5 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif PWI PF01480.15 MSTRG.16088.5_2 - 6e-10 39.2 0.3 1.3e-09 38.1 0.3 1.6 1 0 0 1 1 1 1 PWI domain zf-CCCH PF00642.22 MSTRG.16088.5_2 - 0.00063 19.5 2.9 0.0012 18.6 2.9 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) COG5 PF10392.7 MSTRG.16088.5_2 - 0.0033 17.5 9.2 0.0087 16.1 9.2 1.7 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Nup35_RRM PF05172.11 MSTRG.16088.5_2 - 0.038 13.8 0.0 1.8 8.4 0.0 2.9 2 1 0 2 2 2 0 Nup53/35/40-type RNA recognition motif MIP-T3 PF10243.7 MSTRG.16088.5_2 - 0.08 11.5 43.7 0.0034 16.0 26.5 2.2 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 RRM_3 PF08777.9 MSTRG.16088.5_2 - 0.14 12.1 0.0 0.14 12.1 0.0 3.0 3 0 0 3 3 3 0 RNA binding motif DUF1496 PF07383.10 MSTRG.16088.5_2 - 0.21 11.1 0.4 0.42 10.1 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1496) IncA PF04156.12 MSTRG.16088.5_2 - 0.95 9.1 9.5 2.2 7.9 9.5 1.6 1 0 0 1 1 1 0 IncA protein Zip PF02535.20 MSTRG.6279.1_1 - 0.24 10.5 4.4 0.35 9.9 4.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Lamp PF01299.15 MSTRG.6279.1_1 - 0.81 9.0 12.4 1.6 8.0 12.4 1.4 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) Pkinase PF00069.23 MSTRG.6279.1_2 - 2.3e-65 220.4 0.0 3.1e-65 220.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.6279.1_2 - 3.4e-31 108.3 0.0 4.8e-31 107.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.6279.1_2 - 7.4e-07 28.6 0.0 1.5e-06 27.6 0.0 1.5 2 0 0 2 2 2 1 Kinase-like APH PF01636.21 MSTRG.6279.1_2 - 0.036 13.9 0.0 8.2 6.1 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family PDEase_I PF00233.17 MSTRG.18818.1_1 - 2.2e-91 305.7 4.7 3.2e-91 305.2 4.7 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase GMP_PDE_delta PF05351.9 MSTRG.16989.2_2 - 8.4e-74 246.7 0.9 1.1e-73 246.4 0.9 1.1 1 0 0 1 1 1 1 GMP-PDE, delta subunit HEAT_2 PF13646.4 MSTRG.8467.1_3 - 8.8e-37 125.2 6.1 6.4e-13 48.8 0.4 4.0 2 2 2 4 4 4 4 HEAT repeats HEAT_PBS PF03130.14 MSTRG.8467.1_3 - 1.7e-27 93.1 12.6 0.00022 21.5 0.0 6.8 7 0 0 7 7 7 5 PBS lyase HEAT-like repeat HEAT PF02985.20 MSTRG.8467.1_3 - 1.9e-06 27.5 2.4 0.97 9.7 0.0 4.8 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.4 MSTRG.8467.1_3 - 3.1e-06 27.4 3.7 0.01 16.1 0.4 4.4 3 2 1 4 4 4 1 HEAT-like repeat Arm PF00514.21 MSTRG.8467.1_3 - 0.084 12.8 0.1 0.97 9.4 0.0 2.7 2 1 0 2 2 2 0 Armadillo/beta-catenin-like repeat TetR_C_11 PF16859.3 MSTRG.8467.1_3 - 0.12 12.6 3.7 0.28 11.4 1.8 2.4 2 0 0 2 2 2 0 Bacterial transcriptional repressor C-terminal TAF6_C PF07571.11 MSTRG.8467.1_3 - 0.13 12.5 0.0 36 4.7 0.0 2.9 3 0 0 3 3 3 0 TAF6 C-terminal HEAT repeat domain TPR_14 PF13428.4 MSTRG.8467.1_3 - 1.6 9.6 8.2 6.1 7.8 0.2 4.5 4 2 2 6 6 6 0 Tetratricopeptide repeat HTH_Tnp_Tc3_2 PF01498.16 MSTRG.10788.1_1 - 0.0061 16.7 1.3 0.012 15.7 1.3 1.5 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.4 MSTRG.10788.1_1 - 0.089 12.3 0.5 0.26 10.9 0.3 1.9 2 1 0 2 2 2 0 Winged helix-turn helix Calsequestrin PF01216.15 MSTRG.8161.4_1 - 1.6e-178 593.5 25.7 1.6e-178 593.5 25.7 2.2 1 1 1 2 2 2 1 Calsequestrin Thioredoxin_6 PF13848.4 MSTRG.8161.4_1 - 9.5e-19 67.9 8.2 8.8e-16 58.3 2.8 2.5 2 1 0 2 2 2 2 Thioredoxin-like domain Nop14 PF04147.10 MSTRG.8161.4_1 - 1.8 6.6 40.0 2.5 6.1 40.0 1.1 1 0 0 1 1 1 0 Nop14-like family Kinesin_assoc PF16183.3 MSTRG.28472.1_3 - 5.9e-13 49.2 0.1 6e-13 49.2 0.1 1.0 1 0 0 1 1 1 1 Kinesin-associated WD40 PF00400.30 MSTRG.23290.1_2 - 5.1e-15 55.5 17.4 0.00027 21.5 0.2 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat SNF2_N PF00176.21 MSTRG.4942.1_1 - 2.7e-71 240.0 0.8 2.7e-71 240.0 0.8 2.4 2 0 0 2 2 2 1 SNF2 family N-terminal domain Bromodomain PF00439.23 MSTRG.4942.1_1 - 3.4e-20 71.8 0.0 2.6e-19 68.9 0.0 2.5 2 0 0 2 2 2 1 Bromodomain HSA PF07529.11 MSTRG.4942.1_1 - 5.3e-20 71.4 16.7 5.3e-20 71.4 16.7 4.3 4 0 0 4 4 4 1 HSA Helicase_C PF00271.29 MSTRG.4942.1_1 - 3.2e-19 69.2 0.1 2.7e-18 66.2 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain BRK PF07533.14 MSTRG.4942.1_1 - 1.7e-17 62.6 0.1 3.5e-17 61.6 0.1 1.6 1 0 0 1 1 1 1 BRK domain SnAC PF14619.4 MSTRG.4942.1_1 - 2.7e-16 59.9 6.9 2.7e-16 59.9 6.9 6.0 6 2 1 8 8 8 1 Snf2-ATP coupling, chromatin remodelling complex ResIII PF04851.13 MSTRG.4942.1_1 - 1.1e-07 31.9 3.0 1.2e-07 31.8 0.0 2.6 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.27 MSTRG.4942.1_1 - 0.0023 17.6 0.0 0.0056 16.3 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2009 PF09418.8 MSTRG.4942.1_1 - 2.6 6.9 10.7 2.2 7.1 8.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2009) MBOAT PF03062.17 MSTRG.9153.1_2 - 8.7e-32 110.7 7.2 1.7e-31 109.7 7.2 1.4 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family CD20 PF04103.13 MSTRG.14307.1_3 - 8.5e-16 58.3 30.4 2e-13 50.6 21.7 3.0 2 1 0 2 2 2 2 CD20-like family ENTH PF01417.18 MSTRG.6392.1_3 - 3.2e-50 169.2 0.4 5.7e-50 168.4 0.1 1.6 2 0 0 2 2 2 1 ENTH domain ANTH PF07651.14 MSTRG.6392.1_3 - 4.9e-05 22.3 0.1 7e-05 21.8 0.1 1.2 1 0 0 1 1 1 1 ANTH domain VHS PF00790.17 MSTRG.6392.1_3 - 0.0022 17.7 0.1 0.0037 17.0 0.1 1.3 1 0 0 1 1 1 1 VHS domain UIM PF02809.18 MSTRG.6392.1_3 - 1.4 8.9 9.9 0.7 9.8 5.1 2.3 2 0 0 2 2 2 0 Ubiquitin interaction motif Ets PF00178.20 MSTRG.1385.1_3 - 1.6e-30 105.3 2.1 3.1e-30 104.3 2.1 1.5 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.14 MSTRG.1385.1_3 - 3.6e-12 45.9 0.3 1.2e-11 44.3 0.3 1.8 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_2 PF07647.15 MSTRG.1385.1_3 - 0.024 14.6 0.0 0.06 13.3 0.0 1.7 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) AT_hook PF02178.17 MSTRG.1385.1_3 - 0.29 11.0 5.3 0.61 10.0 5.3 1.6 1 0 0 1 1 1 0 AT hook motif Ubiq_cyt_C_chap PF03981.10 MSTRG.13684.1_1 - 2.4e-37 128.0 0.2 3.4e-37 127.5 0.2 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone Phospholip_B PF04916.11 MSTRG.13684.1_1 - 0.067 11.6 0.0 0.093 11.1 0.0 1.1 1 0 0 1 1 1 0 Phospholipase B PH PF00169.27 MSTRG.22508.2_3 - 3e-11 43.6 0.0 5.1e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 MSTRG.22508.2_3 - 4.6e-05 23.7 0.2 9.5e-05 22.6 0.2 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.4 MSTRG.22508.2_3 - 0.018 15.2 0.0 0.03 14.5 0.0 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain Filamin PF00630.17 MSTRG.12971.6_3 - 1.8e-22 80.0 0.1 1.4e-11 45.0 0.0 2.2 2 0 0 2 2 2 2 Filamin/ABP280 repeat TonB_C PF03544.12 MSTRG.12971.6_3 - 0.11 12.8 0.1 1.1 9.6 0.0 2.3 2 0 0 2 2 2 0 Gram-negative bacterial TonB protein C-terminal EMP24_GP25L PF01105.22 MSTRG.12971.6_3 - 0.15 11.8 0.0 8.4 6.2 0.0 2.1 1 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Pur_DNA_glyco PF02245.14 MSTRG.5257.1_2 - 1.6e-32 112.2 0.0 2.1e-32 111.8 0.0 1.2 1 0 0 1 1 1 1 Methylpurine-DNA glycosylase (MPG) Myosin_head PF00063.19 MSTRG.15730.1_2 - 5e-47 160.4 1.9 5.4e-47 160.3 1.9 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) Arc_PepC_II PF06847.9 MSTRG.15730.1_2 - 0.083 13.3 0.1 0.11 12.9 0.1 1.2 1 1 0 1 1 1 0 Archaeal Peptidase A24 C-terminus Type II FERM_M PF00373.16 MSTRG.8759.3_1 - 6e-21 74.9 2.4 6e-21 74.9 2.4 1.9 2 0 0 2 2 2 1 FERM central domain FERM_N PF09379.8 MSTRG.8759.3_1 - 3.9e-16 58.6 0.5 9.6e-16 57.4 0.2 1.8 2 0 0 2 2 2 1 FERM N-terminal domain FERM_C PF09380.8 MSTRG.8759.3_1 - 3.8e-15 55.9 0.1 7.1e-15 55.0 0.1 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain Y_phosphatase PF00102.25 MSTRG.8759.3_1 - 2.9e-07 30.2 0.1 5e-07 29.4 0.1 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CEP19 PF14933.4 MSTRG.23824.1_1 - 5.9e-44 150.1 0.4 9.2e-44 149.5 0.4 1.2 1 0 0 1 1 1 1 CEP19-like protein NUDIX_4 PF14815.4 MSTRG.24027.1_2 - 7.8e-21 74.0 0.7 2.2e-20 72.5 0.1 2.1 3 0 0 3 3 3 1 NUDIX domain HhH-GPD PF00730.23 MSTRG.24027.1_2 - 3.2e-19 69.3 0.0 6.7e-19 68.2 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.21 MSTRG.24027.1_2 - 9.2e-08 31.4 0.0 2.1e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.7 MSTRG.24027.1_2 - 0.0044 17.2 6.8 0.0044 17.2 6.8 2.5 3 0 0 3 3 3 1 Iron-sulfur binding domain of endonuclease III CDC27 PF09507.8 MSTRG.24027.1_2 - 0.01 15.1 0.9 0.017 14.4 0.9 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Whib PF02467.14 MSTRG.24027.1_2 - 0.046 14.2 0.7 0.24 11.9 0.7 2.2 1 0 0 1 1 1 0 Transcription factor WhiB PMEI PF04043.13 MSTRG.18409.2_1 - 0.035 14.4 0.5 0.063 13.6 0.5 1.4 1 0 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor SPRY PF00622.26 MSTRG.18409.2_3 - 2.3e-20 72.8 0.2 3.9e-20 72.0 0.2 1.4 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_3 PF13920.4 MSTRG.18409.2_3 - 3.6e-08 33.0 13.8 3.6e-08 33.0 13.8 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 MSTRG.18409.2_3 - 0.0015 18.3 9.7 0.0047 16.6 9.7 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Peptidase_C1 PF00112.21 MSTRG.29201.1_2 - 2.2e-23 83.4 0.0 2.4e-23 83.3 0.0 1.0 1 0 0 1 1 1 1 Papain family cysteine protease LSR PF05624.12 MSTRG.22310.2_2 - 3.9e-21 74.6 38.7 5.3e-21 74.2 38.7 1.2 1 0 0 1 1 1 1 Lipolysis stimulated receptor (LSR) PK PF00224.19 MSTRG.5466.2_3 - 3.9e-164 545.5 0.6 4.8e-164 545.2 0.6 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.14 MSTRG.5466.2_3 - 6.3e-33 113.3 0.0 1.3e-32 112.3 0.0 1.6 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.12 MSTRG.5466.2_3 - 0.0064 15.5 0.1 0.012 14.6 0.1 1.4 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family Peptidase_M19 PF01244.19 MSTRG.11309.2_1 - 6e-119 396.8 0.0 7.4e-119 396.5 0.0 1.1 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) MIF4G_like_2 PF09090.9 MSTRG.15883.1_3 - 3.1e-86 289.0 7.4 4.8e-86 288.3 7.4 1.3 1 0 0 1 1 1 1 MIF4G like MIF4G_like PF09088.9 MSTRG.15883.1_3 - 4.6e-38 130.7 0.3 2e-37 128.6 0.2 2.0 2 0 0 2 2 2 1 MIF4G like Vfa1 PF08432.8 MSTRG.15883.1_3 - 0.015 15.5 5.2 0.027 14.7 5.2 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 PHM7_cyt PF14703.4 MSTRG.15883.1_3 - 0.015 15.4 3.4 0.029 14.5 3.4 1.4 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter Jnk-SapK_ap_N PF09744.7 MSTRG.15883.1_3 - 0.017 15.2 7.3 0.034 14.2 7.3 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Mnd1 PF03962.13 MSTRG.15883.1_3 - 0.017 14.9 5.9 0.031 14.0 5.9 1.4 1 0 0 1 1 1 0 Mnd1 family DUF342 PF03961.11 MSTRG.15883.1_3 - 0.022 13.2 2.1 0.031 12.8 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF1664 PF07889.10 MSTRG.15883.1_3 - 0.059 13.2 3.0 0.13 12.1 3.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF106 PF01956.14 MSTRG.15883.1_3 - 0.062 12.9 2.1 0.11 12.1 2.1 1.3 1 0 0 1 1 1 0 Integral membrane protein DUF106 HemX PF04375.12 MSTRG.15883.1_3 - 0.072 12.2 4.4 0.13 11.4 4.4 1.4 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase tRNA_bind_2 PF13725.4 MSTRG.15883.1_3 - 0.079 12.6 6.8 0.15 11.6 6.8 1.4 1 0 0 1 1 1 0 Possible tRNA binding domain OmpH PF03938.12 MSTRG.15883.1_3 - 0.091 12.6 9.9 0.17 11.8 9.9 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF1510 PF07423.9 MSTRG.15883.1_3 - 0.094 12.0 6.3 0.15 11.4 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) GBP_C PF02841.12 MSTRG.15883.1_3 - 0.11 11.8 8.3 0.18 11.0 8.3 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain DUF4407 PF14362.4 MSTRG.15883.1_3 - 0.11 11.7 0.5 0.18 11.0 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) IncA PF04156.12 MSTRG.15883.1_3 - 0.12 12.1 4.5 0.2 11.3 4.5 1.3 1 0 0 1 1 1 0 IncA protein AAA_11 PF13086.4 MSTRG.15883.1_3 - 0.14 11.7 3.4 0.24 11.0 3.4 1.3 1 0 0 1 1 1 0 AAA domain Folliculin PF11704.6 MSTRG.15883.1_3 - 0.15 11.8 4.8 0.24 11.1 4.8 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Swi5 PF07061.9 MSTRG.15883.1_3 - 0.15 12.0 8.1 1.1 9.2 1.8 2.5 2 0 0 2 2 2 0 Swi5 DUF2203 PF09969.7 MSTRG.15883.1_3 - 0.16 12.6 3.4 0.32 11.6 3.4 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Cob_adeno_trans PF01923.16 MSTRG.15883.1_3 - 0.26 11.3 1.6 0.61 10.1 1.6 1.6 1 0 0 1 1 1 0 Cobalamin adenosyltransferase CLZ PF16526.3 MSTRG.15883.1_3 - 0.33 11.2 8.9 3.9 7.7 1.5 3.2 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels PRKG1_interact PF15898.3 MSTRG.15883.1_3 - 0.42 11.4 8.6 0.86 10.4 8.6 1.5 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Alanine_zipper PF11839.6 MSTRG.15883.1_3 - 0.45 10.7 3.2 3.3 7.9 0.6 2.3 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein SOGA PF11365.6 MSTRG.15883.1_3 - 0.68 11.0 10.4 1.4 10.0 10.4 1.5 1 0 0 1 1 1 0 Protein SOGA Atg14 PF10186.7 MSTRG.15883.1_3 - 0.89 8.4 6.6 2.8 6.8 5.4 2.0 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 CorA PF01544.16 MSTRG.15883.1_3 - 1.2 8.2 5.8 1.2 8.2 0.3 2.3 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Prefoldin_2 PF01920.18 MSTRG.15883.1_3 - 1.3 8.9 14.4 4.5 7.2 2.2 2.4 2 0 0 2 2 2 0 Prefoldin subunit DASH_Spc34 PF08657.8 MSTRG.15883.1_3 - 2.5 7.8 10.5 4.5 6.9 10.5 1.4 1 0 0 1 1 1 0 DASH complex subunit Spc34 Fib_alpha PF08702.8 MSTRG.15883.1_3 - 3.1 7.8 9.8 1.9 8.6 6.7 2.1 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family RmuC PF02646.14 MSTRG.15883.1_3 - 3.8 6.4 10.8 1.6 7.7 0.8 2.3 1 1 1 2 2 2 0 RmuC family DivIC PF04977.13 MSTRG.15883.1_3 - 5 6.8 8.5 7.1 6.3 1.6 2.6 2 0 0 2 2 2 0 Septum formation initiator SlyX PF04102.10 MSTRG.15883.1_3 - 7.1 7.2 9.6 13 6.4 2.4 3.0 1 1 1 2 2 2 0 SlyX Coiled-coil_56 PF09813.7 MSTRG.423.1_1 - 7.3e-35 118.9 0.1 1.4e-34 118.0 0.1 1.4 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 56 MFS_2 PF13347.4 MSTRG.423.1_1 - 3.1e-19 68.7 15.4 1.2e-18 66.7 13.9 2.5 2 1 0 2 2 2 1 MFS/sugar transport protein Nup88 PF10168.7 MSTRG.27159.1_3 - 2.1e-260 865.4 0.0 2.4e-260 865.2 0.0 1.0 1 0 0 1 1 1 1 Nuclear pore component IncA PF04156.12 MSTRG.27159.1_3 - 0.00028 20.6 5.3 0.00061 19.5 5.3 1.5 1 0 0 1 1 1 1 IncA protein CENP-Q PF13094.4 MSTRG.27159.1_3 - 0.84 9.7 10.1 1.5 8.8 10.1 1.3 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit zf-H2C2_2 PF13465.4 MSTRG.16115.1_1 - 1.1e-81 265.7 78.0 1.8e-09 37.4 1.1 11.9 11 0 0 11 11 11 11 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.16115.1_1 - 2.7e-41 137.6 111.1 3.1e-05 24.1 3.7 11.8 12 0 0 12 12 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.16115.1_1 - 6.8e-32 107.2 91.5 0.0006 20.3 1.9 11.9 11 0 0 11 11 11 11 C2H2-type zinc finger zf-met PF12874.5 MSTRG.16115.1_1 - 2.8e-15 56.0 72.5 0.0022 18.2 0.3 11.3 11 0 0 11 11 11 8 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 MSTRG.16115.1_1 - 1.2e-10 41.0 77.0 0.0017 18.1 0.5 12.0 11 2 0 11 11 11 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.16115.1_1 - 3.3e-06 27.1 41.2 0.15 12.3 2.0 10.8 11 0 0 11 11 11 3 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 MSTRG.16115.1_1 - 4.1e-05 23.6 64.5 0.082 13.1 2.0 7.6 4 2 1 7 7 6 4 Drought induced 19 protein (Di19), zinc-binding BolA PF01722.16 MSTRG.16115.1_1 - 0.0093 16.1 22.9 1.8 8.8 0.8 6.9 2 2 2 4 4 4 1 BolA-like protein Ta0938 PF11494.6 MSTRG.16115.1_1 - 0.055 13.6 23.2 0.098 12.8 0.2 6.4 1 1 6 7 7 7 0 Ta0938 Elf1 PF05129.11 MSTRG.16115.1_1 - 0.065 13.2 52.4 0.12 12.3 1.9 6.9 1 1 6 7 7 7 0 Transcription elongation factor Elf1 like LIM PF00412.20 MSTRG.16115.1_1 - 0.066 13.3 54.5 0.14 12.3 3.3 8.8 1 1 9 10 10 10 0 LIM domain ADK_lid PF05191.12 MSTRG.16115.1_1 - 0.13 12.2 22.1 0.56 10.1 0.3 6.3 5 1 0 5 5 5 0 Adenylate kinase, active site lid zf-Sec23_Sec24 PF04810.13 MSTRG.16115.1_1 - 0.17 11.9 39.8 6.5 6.8 0.1 10.1 7 3 4 11 11 11 0 Sec23/Sec24 zinc finger zinc_ribbon_15 PF17032.3 MSTRG.16115.1_1 - 0.38 11.4 38.7 4.3 8.0 1.0 6.2 1 1 6 7 7 7 0 zinc-ribbon family PHD PF00628.27 MSTRG.16115.1_1 - 2.7 7.8 49.6 0.32 10.8 2.9 6.7 2 1 6 8 8 8 0 PHD-finger AAA_9 PF12781.5 MSTRG.24830.1_2 - 1.5e-85 285.7 1.4 1.5e-85 285.7 1.4 2.1 2 1 0 2 2 2 1 ATP-binding dynein motor region D5 MT PF12777.5 MSTRG.24830.1_2 - 2.1e-28 99.2 0.6 4.1e-28 98.3 0.6 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor DUF724 PF05266.12 MSTRG.24830.1_2 - 4.5 6.9 14.9 4.4 7.0 5.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF724) CBFD_NFYB_HMF PF00808.21 MSTRG.8490.1_2 - 4.9e-21 74.7 0.5 7.7e-21 74.0 0.5 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.22 MSTRG.8490.1_2 - 0.011 16.0 0.0 0.017 15.4 0.0 1.2 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 CENP-W PF15510.4 MSTRG.8490.1_2 - 0.047 13.9 0.0 0.091 12.9 0.0 1.5 1 0 0 1 1 1 0 CENP-W protein SPC22 PF04573.10 MSTRG.13262.1_1 - 3e-57 192.7 0.0 3.7e-57 192.4 0.0 1.1 1 0 0 1 1 1 1 Signal peptidase subunit Trypsin PF00089.24 MSTRG.17794.1_1 - 1.8e-58 197.9 0.0 2.8e-58 197.2 0.0 1.3 1 0 0 1 1 1 1 Trypsin Sushi PF00084.18 MSTRG.17794.1_1 - 1.3e-10 41.6 0.1 3.2e-10 40.4 0.1 1.8 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) Trypsin_2 PF13365.4 MSTRG.17794.1_1 - 2.8e-06 28.1 0.7 5.7e-06 27.1 0.7 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain CUB PF00431.18 MSTRG.17794.1_1 - 6.7e-06 26.3 0.0 1.2e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 CUB domain HRM PF02793.20 MSTRG.17794.1_1 - 0.051 13.7 0.1 0.16 12.1 0.1 1.8 1 0 0 1 1 1 0 Hormone receptor domain Aminotran_1_2 PF00155.19 MSTRG.14182.1_3 - 1.5e-77 261.1 0.0 2e-77 260.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Preseq_ALAS PF09029.8 MSTRG.14182.1_3 - 1.6e-41 141.4 2.9 3.7e-41 140.1 2.9 1.7 1 0 0 1 1 1 1 5-aminolevulinate synthase presequence Aminotran_5 PF00266.17 MSTRG.14182.1_3 - 1.2e-05 24.3 0.0 3.4e-05 22.8 0.0 1.6 2 0 0 2 2 2 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.18 MSTRG.14182.1_3 - 0.00015 20.3 0.0 0.00026 19.5 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme AAA_13 PF13166.4 MSTRG.14182.1_3 - 0.0065 15.1 0.2 0.014 14.0 0.0 1.5 2 0 0 2 2 2 1 AAA domain E2_bind PF08825.8 MSTRG.14182.1_3 - 0.038 14.0 0.7 0.12 12.4 0.7 1.8 1 0 0 1 1 1 0 E2 binding domain Cyclin_N PF00134.21 MSTRG.27981.1_2 - 1.1e-19 70.3 0.2 2e-19 69.5 0.2 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 MSTRG.27981.1_2 - 0.011 15.7 0.1 0.021 14.8 0.1 1.5 1 0 0 1 1 1 0 Cyclin, C-terminal domain DUF4443 PF14544.4 MSTRG.27981.1_2 - 0.099 12.5 0.1 0.9 9.4 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4443) CDI PF02234.17 MSTRG.24021.1_1 - 0.081 13.0 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor HECT PF00632.23 MSTRG.24021.1_2 - 6.3e-88 295.1 0.1 9.8e-88 294.4 0.1 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) AZUL PF16558.3 MSTRG.24021.1_2 - 1.9e-17 63.1 1.6 3.7e-17 62.2 1.6 1.5 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A T-box PF00907.20 MSTRG.1302.3_1 - 5.5e-69 231.9 1.0 1.2e-68 230.9 1.0 1.6 1 0 0 1 1 1 1 T-box DUF4801 PF16059.3 MSTRG.1302.3_1 - 9.8e-12 44.5 9.3 2.3e-11 43.4 9.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4801) zf-CCHC_2 PF13696.4 MSTRG.1302.3_3 - 0.099 12.3 4.8 0.046 13.4 1.6 2.2 2 0 0 2 2 2 0 Zinc knuckle VPS9 PF02204.16 MSTRG.9987.2_2 - 3.5e-28 97.7 0.0 6e-28 97.0 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ig_2 PF13895.4 MSTRG.9987.2_2 - 2.4e-18 66.1 0.1 4.7e-06 26.7 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.9987.2_2 - 3.2e-16 59.6 0.0 1.7e-07 31.6 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain zf-A20 PF01754.14 MSTRG.9987.2_2 - 9.8e-12 44.5 5.1 3.3e-11 42.8 5.1 2.0 1 0 0 1 1 1 1 A20-like zinc finger ig PF00047.23 MSTRG.9987.2_2 - 4.9e-08 32.9 0.0 0.011 15.7 0.0 3.9 3 1 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 MSTRG.9987.2_2 - 0.00044 20.2 0.4 0.21 11.6 0.0 3.5 3 1 0 3 3 3 1 Immunoglobulin V-set domain Ig_5 PF16681.3 MSTRG.9987.2_2 - 0.00077 19.7 0.0 0.42 10.9 0.0 3.1 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain I-set PF07679.14 MSTRG.9987.2_2 - 0.0024 17.7 0.0 0.025 14.5 0.0 2.6 3 0 0 3 3 3 1 Immunoglobulin I-set domain Ras PF00071.20 MSTRG.6065.2_3 - 5.5e-60 201.5 0.1 7.7e-60 201.0 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.6065.2_3 - 5.1e-33 113.7 0.0 8.5e-33 113.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.6065.2_3 - 4.9e-11 42.3 0.0 6.8e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 MSTRG.6065.2_3 - 0.0012 18.1 0.0 0.0017 17.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 MSTRG.6065.2_3 - 0.0022 17.4 0.0 0.0042 16.5 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 MSTRG.6065.2_3 - 0.0086 15.9 0.1 0.84 9.4 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 MSTRG.6065.2_3 - 0.011 15.7 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase VGLL4 PF15245.4 MSTRG.21049.1_3 - 9.8e-85 283.9 8.7 3.2e-84 282.2 8.7 1.8 1 1 0 1 1 1 1 Transcription cofactor vestigial-like protein 4 Vg_Tdu PF07545.12 MSTRG.21049.1_3 - 0.0056 16.2 0.0 2.8 7.6 0.0 2.5 2 0 0 2 2 2 2 Vestigial/Tondu family CAP_N PF01213.17 MSTRG.12134.2_2 - 7.6 5.8 8.2 14 4.9 8.2 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal BTB PF00651.29 MSTRG.12134.2_3 - 7.5e-25 87.2 0.2 1.3e-24 86.5 0.2 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 MSTRG.12134.2_3 - 2.5e-20 71.8 43.4 5.8e-07 29.5 0.5 6.1 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.12134.2_3 - 8.6e-12 44.7 45.6 0.00031 20.9 1.1 6.6 6 0 0 6 6 6 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.12134.2_3 - 4.2e-05 23.9 43.5 0.026 15.2 0.7 6.5 6 0 0 6 6 6 3 C2H2-type zinc finger zf-met PF12874.5 MSTRG.12134.2_3 - 9.6e-05 22.5 27.5 0.0018 18.5 0.8 5.1 5 0 0 5 5 5 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 MSTRG.12134.2_3 - 0.016 15.0 0.1 0.016 15.0 0.1 5.5 5 0 0 5 5 5 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.12134.2_3 - 0.087 13.0 13.8 3.3 8.0 0.1 4.2 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 MSTRG.12134.2_3 - 0.087 13.0 5.0 3.5 7.8 0.2 2.5 2 0 0 2 2 2 0 zinc-finger-containing domain Zn-ribbon_8 PF09723.8 MSTRG.12134.2_3 - 3.7 7.6 19.8 0.43 10.6 1.3 4.5 2 1 3 5 5 5 0 Zinc ribbon domain Evr1_Alr PF04777.11 MSTRG.12134.2_3 - 6.9 7.1 7.6 20 5.7 2.6 3.4 1 1 1 2 2 2 0 Erv1 / Alr family TMEM52 PF14979.4 MSTRG.9695.3_1 - 0.026 14.3 0.1 0.026 14.3 0.1 2.0 2 0 0 2 2 2 0 Transmembrane 52 Ras PF00071.20 MSTRG.9695.3_3 - 4.1e-53 179.2 0.1 5.6e-53 178.7 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.9695.3_3 - 6.1e-32 110.2 0.0 9.2e-32 109.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.9695.3_3 - 4.8e-11 42.3 0.0 9.2e-11 41.4 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 MSTRG.9695.3_3 - 0.0028 17.5 0.0 0.91 9.3 0.1 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 MSTRG.9695.3_3 - 0.0048 16.8 0.0 0.008 16.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 MSTRG.9695.3_3 - 0.0063 15.9 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_24 PF13479.4 MSTRG.9695.3_3 - 0.13 11.8 0.0 0.26 10.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain TPP_enzyme_M PF00205.20 MSTRG.9695.3_3 - 0.16 11.6 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain RRM_1 PF00076.20 MSTRG.17635.4_1 - 7.2e-30 102.5 0.0 5.2e-17 61.3 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 MSTRG.17635.4_1 - 0.0031 17.3 0.0 0.041 13.7 0.0 2.2 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.3 MSTRG.17635.4_1 - 0.0058 16.6 0.0 0.02 14.9 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif RRM_3 PF08777.9 MSTRG.17635.4_1 - 0.013 15.4 0.0 1.8 8.5 0.0 2.2 2 0 0 2 2 2 0 RNA binding motif RRM_occluded PF16842.3 MSTRG.17635.4_1 - 0.09 12.5 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif DUF2457 PF10446.7 MSTRG.17635.4_1 - 1.2 8.1 10.2 1.6 7.7 10.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) EGF_CA PF07645.13 MSTRG.13516.1_3 - 5.9e-59 195.9 105.3 5.9e-11 42.2 8.9 8.6 8 0 0 8 8 8 7 Calcium-binding EGF domain cEGF PF12662.5 MSTRG.13516.1_3 - 4.7e-44 147.8 60.0 1.2e-09 37.8 1.7 8.4 8 0 0 8 8 8 7 Complement Clr-like EGF-like FXa_inhibition PF14670.4 MSTRG.13516.1_3 - 9.7e-29 99.2 102.5 6.8e-07 29.3 7.5 8.2 7 1 1 8 8 8 7 Coagulation Factor Xa inhibitory site EGF PF00008.25 MSTRG.13516.1_3 - 4.4e-25 87.5 95.4 3e-05 24.1 7.8 8.4 8 0 0 8 8 8 7 EGF-like domain hEGF PF12661.5 MSTRG.13516.1_3 - 3.7e-22 78.0 102.2 3.2e-05 24.3 6.5 9.1 9 0 0 9 9 9 7 Human growth factor-like EGF EGF_3 PF12947.5 MSTRG.13516.1_3 - 1.8e-12 47.1 96.8 0.00046 20.2 8.1 9.6 7 3 1 9 9 9 6 EGF domain TB PF00683.15 MSTRG.13516.1_3 - 4.8e-12 45.2 8.4 4.8e-12 45.2 8.4 2.9 2 0 0 2 2 2 1 TB domain Plasmod_Pvs28 PF06247.9 MSTRG.13516.1_3 - 1.3e-06 28.5 79.9 0.022 14.9 3.3 8.0 8 0 0 8 8 8 6 Pvs28 EGF domain EGF_MSP1_1 PF12946.5 MSTRG.13516.1_3 - 0.011 15.6 73.1 0.08 12.9 0.6 8.2 8 0 0 8 8 8 0 MSP1 EGF domain 1 RGS PF00615.17 MSTRG.10299.3_3 - 2.2e-31 108.5 1.0 4e-31 107.6 1.0 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain RBD PF02196.13 MSTRG.10299.3_3 - 3.4e-28 97.4 0.0 8.9e-20 70.4 0.0 2.4 2 0 0 2 2 2 2 Raf-like Ras-binding domain GoLoco PF02188.15 MSTRG.10299.3_3 - 1.2e-05 24.6 2.7 2.2e-05 23.7 2.7 1.4 1 0 0 1 1 1 1 GoLoco motif TUG-UBL1 PF11470.6 MSTRG.10299.3_3 - 0.0023 18.0 0.2 0.21 11.7 0.1 3.0 3 0 0 3 3 3 1 TUG ubiquitin-like domain Peptidase_S28 PF05577.10 MSTRG.26855.1_1 - 5.7e-78 262.5 0.0 7.6e-78 262.1 0.0 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Hydrolase_4 PF12146.6 MSTRG.26855.1_1 - 0.00035 19.8 0.0 0.00053 19.2 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.18 MSTRG.26855.1_1 - 0.0027 17.2 0.0 0.0047 16.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S37 PF05576.9 MSTRG.26855.1_1 - 0.0038 15.8 0.0 0.0061 15.1 0.0 1.2 1 0 0 1 1 1 1 PS-10 peptidase S37 DUF2920 PF11144.6 MSTRG.26855.1_1 - 0.027 13.5 0.2 0.042 12.9 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) Abhydrolase_6 PF12697.5 MSTRG.26855.1_1 - 0.038 14.5 0.0 0.069 13.6 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family SH3_1 PF00018.26 MSTRG.26855.1_3 - 7.2e-17 60.6 0.0 2e-13 49.6 0.0 2.6 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.4 MSTRG.26855.1_3 - 6.5e-11 41.8 0.1 3.1e-08 33.2 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.15 MSTRG.26855.1_3 - 9.6e-09 34.7 0.0 4.7e-06 26.1 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain TPR_2 PF07719.15 MSTRG.26855.1_3 - 0.00045 20.0 1.0 8.4 6.7 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.26855.1_3 - 0.011 15.9 3.0 2.3 8.4 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat KA1 PF02149.17 MSTRG.25918.3_1 - 6.1e-21 73.8 0.1 1.6e-20 72.5 0.0 1.8 2 0 0 2 2 2 1 Kinase associated domain 1 SelP_N PF04592.12 MSTRG.25918.3_1 - 2.6 7.3 16.4 4.6 6.4 16.4 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region MRF_C1 PF13887.4 MSTRG.21042.1_1 - 0.14 11.2 0.4 0.25 10.4 0.4 1.3 1 0 0 1 1 1 0 Myelin gene regulatory factor -C-terminal domain 1 Ribosomal_L10 PF00466.18 MSTRG.21042.1_3 - 8.3e-21 73.9 0.3 1.3e-20 73.3 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 DUF349 PF03993.10 MSTRG.21042.1_3 - 0.019 15.1 0.2 0.049 13.8 0.2 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) PGP_phosphatase PF09419.8 MSTRG.21042.1_3 - 0.089 12.3 0.1 0.19 11.2 0.1 1.5 1 1 0 1 1 1 0 Mitochondrial PGP phosphatase SMP_LBD PF17047.3 MSTRG.10477.3_2 - 1.6e-99 330.6 0.5 1.6e-99 330.6 0.5 1.6 2 0 0 2 2 2 1 Synaptotagmin-like mitochondrial-lipid-binding domain C2 PF00168.28 MSTRG.10477.3_2 - 2.4e-22 79.0 0.0 5.3e-22 77.9 0.0 1.6 1 0 0 1 1 1 1 C2 domain C1q PF00386.19 MSTRG.11733.1_3 - 1.3e-33 115.7 0.0 2.6e-33 114.8 0.0 1.5 1 0 0 1 1 1 1 C1q domain Caprin-1_C PF12287.6 MSTRG.11733.1_3 - 0.00012 22.3 6.9 0.00035 20.7 3.1 2.4 1 1 1 2 2 2 1 Cytoplasmic activation/proliferation-associated protein-1 C term Aha1_N PF09229.9 MSTRG.1257.2_3 - 1e-36 126.0 0.1 1.8e-36 125.2 0.1 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.9 MSTRG.1257.2_3 - 1.8e-21 76.5 0.0 3e-21 75.8 0.0 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein UDPGT PF00201.16 MSTRG.913.2_2 - 9.8e-145 483.0 0.0 1.2e-144 482.7 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 MSTRG.913.2_2 - 0.00035 20.5 0.0 0.00065 19.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain eRF1_2 PF03464.13 MSTRG.913.2_2 - 0.099 12.8 0.0 2 8.6 0.0 2.6 2 1 1 3 3 3 0 eRF1 domain 2 MHC_I PF00129.16 MSTRG.28169.2_2 - 3.5e-32 111.3 0.9 4.5e-32 110.9 0.9 1.1 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Arrestin_N PF00339.27 MSTRG.4634.1_1 - 2.6e-19 69.6 0.1 4.1e-19 69.0 0.1 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.20 MSTRG.4634.1_1 - 1.9e-15 57.3 0.0 3.5e-13 50.0 0.0 2.2 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Vps26 PF03643.13 MSTRG.4634.1_1 - 0.0023 16.8 0.0 0.0037 16.2 0.0 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 NAP PF00956.16 MSTRG.20646.1_2 - 3.1e-109 364.1 7.5 6.7e-109 363.1 7.5 1.6 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) NPR2 PF06218.9 MSTRG.26968.1_1 - 3.6e-90 302.7 5.1 6e-85 285.5 5.1 2.1 1 1 0 1 1 1 1 Nitrogen permease regulator 2 BCDHK_Adom3 PF10436.7 MSTRG.28961.1_1 - 0.066 12.9 0.1 0.08 12.7 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase PRMT5 PF05185.14 MSTRG.5608.1_2 - 5e-09 35.6 0.0 6.6e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PrmA PF06325.11 MSTRG.5608.1_2 - 6.1e-08 32.3 0.2 1.1e-07 31.4 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.4 MSTRG.5608.1_2 - 1.3e-06 28.9 0.1 3.3e-06 27.6 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.12 MSTRG.5608.1_2 - 1.9e-05 24.1 0.1 3.1e-05 23.5 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.5 MSTRG.5608.1_2 - 7e-05 22.7 0.0 0.00012 22.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 MSTRG.5608.1_2 - 0.00018 21.9 0.1 0.00088 19.7 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Met_10 PF02475.14 MSTRG.5608.1_2 - 0.00039 20.1 0.2 0.00058 19.5 0.2 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.13 MSTRG.5608.1_2 - 0.0012 18.4 0.1 0.002 17.6 0.1 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_23 PF13489.4 MSTRG.5608.1_2 - 0.0015 18.3 0.0 0.0028 17.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.9 MSTRG.5608.1_2 - 0.019 13.8 0.0 0.026 13.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_31 PF13847.4 MSTRG.5608.1_2 - 0.03 14.0 0.0 0.051 13.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.16 MSTRG.5608.1_2 - 0.062 12.5 0.0 0.093 11.9 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family FtsJ PF01728.17 MSTRG.5608.1_2 - 0.083 12.9 0.0 0.11 12.4 0.0 1.3 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_24 PF13578.4 MSTRG.5608.1_2 - 0.12 13.3 0.0 0.21 12.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain UCH PF00443.27 MSTRG.3121.5_2 - 3.2e-33 115.2 0.0 3.4e-33 115.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 MSTRG.3121.5_2 - 3.3e-11 43.2 0.0 5e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-MYND PF01753.16 MSTRG.3121.5_2 - 2.5e-09 36.9 12.4 2.5e-09 36.9 12.4 2.4 2 0 0 2 2 2 1 MYND finger USP7_C2 PF14533.4 MSTRG.3121.5_2 - 0.011 15.4 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-specific protease C-terminal MPDZ_u10 PF16667.3 MSTRG.6131.1_1 - 0.65 10.8 6.8 0.21 12.4 2.1 2.5 2 0 0 2 2 2 0 Unstructured region 10 on multiple PDZ protein zf-DHHC PF01529.18 MSTRG.6131.1_3 - 1.8e-35 121.8 8.3 1.8e-35 121.8 8.3 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase I-set PF07679.14 MSTRG.215.4_2 - 1.2e-124 406.6 17.6 3.6e-13 49.3 0.1 11.6 12 0 0 12 12 12 10 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.215.4_2 - 1.1e-76 253.3 13.6 3.3e-08 33.9 0.1 11.3 12 0 0 12 12 12 10 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.215.4_2 - 3.4e-47 158.6 3.7 2.2e-06 27.8 0.1 10.5 10 0 0 10 10 10 7 Immunoglobulin domain ig PF00047.23 MSTRG.215.4_2 - 9e-47 157.0 14.9 2.9e-08 33.6 0.0 10.9 12 0 0 12 12 12 8 Immunoglobulin domain fn3 PF00041.19 MSTRG.215.4_2 - 6.9e-45 151.2 7.4 2.1e-14 53.5 0.2 5.3 6 0 0 6 6 5 3 Fibronectin type III domain V-set PF07686.15 MSTRG.215.4_2 - 2.3e-25 88.7 26.9 0.031 14.3 0.2 16.3 10 8 0 10 10 10 6 Immunoglobulin V-set domain Izumo-Ig PF16706.3 MSTRG.215.4_2 - 3.8e-10 39.5 21.2 0.047 13.6 0.1 9.9 10 0 0 10 10 10 3 Izumo-like Immunoglobulin domain C1-set PF07654.13 MSTRG.215.4_2 - 1.1e-07 32.0 10.4 4.3 7.8 0.1 8.2 8 0 0 8 8 8 1 Immunoglobulin C1-set domain Ig_4 PF16680.3 MSTRG.215.4_2 - 1.4e-05 25.2 21.5 0.44 10.8 0.3 8.2 8 0 0 8 8 8 2 T-cell surface glycoprotein CD3 delta chain Receptor_2B4 PF11465.6 MSTRG.215.4_2 - 2.2e-05 24.5 0.2 1.8 8.7 0.0 5.2 4 0 0 4 4 4 1 Natural killer cell receptor 2B4 Pur_ac_phosph_N PF16656.3 MSTRG.215.4_2 - 4.7e-05 23.7 14.1 0.33 11.4 0.1 6.1 5 1 0 5 5 5 2 Purple acid Phosphatase, N-terminal domain PKD_3 PF16820.3 MSTRG.215.4_2 - 0.11 12.1 2.1 14 5.4 0.0 4.8 5 0 0 5 5 5 0 PKD-like domain Trigger_N PF05697.11 MSTRG.215.4_2 - 0.21 11.8 2.7 15 5.8 0.0 3.3 3 0 0 3 3 3 0 Bacterial trigger factor protein (TF) WD40 PF00400.30 MSTRG.4082.4_2 - 9.7e-45 149.5 7.6 2.2e-09 37.7 0.0 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.13 MSTRG.4082.4_2 - 2e-27 95.9 0.0 3e-27 95.3 0.0 1.3 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.5 MSTRG.4082.4_2 - 7.3e-10 38.9 0.0 0.0006 19.9 0.0 3.5 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 MSTRG.4082.4_2 - 0.13 11.5 0.0 7 5.7 0.0 2.7 1 1 2 3 3 3 0 WD40-like domain Peptidase_C2 PF00648.19 MSTRG.4082.4_3 - 8.8e-133 441.7 0.2 1.2e-132 441.3 0.2 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 MSTRG.4082.4_3 - 6.9e-51 172.1 0.0 1.2e-50 171.4 0.0 1.4 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_1 PF00036.30 MSTRG.4082.4_3 - 6e-10 37.8 2.6 0.00016 20.9 0.2 3.4 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.4 MSTRG.4082.4_3 - 2e-09 36.5 0.6 0.0013 18.4 0.0 4.4 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.4 MSTRG.4082.4_3 - 1.4e-07 31.1 1.1 4.5e-05 23.0 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.4 MSTRG.4082.4_3 - 9.5e-05 22.7 5.9 0.017 15.5 0.2 3.2 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.4082.4_3 - 0.032 13.6 2.2 6.3 6.4 0.1 3.4 4 0 0 4 4 4 0 EF hand Sterol-sensing PF12349.6 MSTRG.12206.1_3 - 9.5e-21 74.1 2.5 1.2e-20 73.8 2.5 1.1 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.16 MSTRG.12206.1_3 - 3.4e-10 38.6 0.1 3.8e-10 38.4 0.1 1.1 1 0 0 1 1 1 1 Patched family DUF1035 PF06281.10 MSTRG.12206.1_3 - 0.22 11.4 3.3 3.3 7.6 0.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1035) FUSC PF04632.10 MSTRG.12206.1_3 - 5.8 5.2 7.5 7.7 4.8 7.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family ANAPC1 PF12859.5 MSTRG.6626.2_1 - 7.4 7.0 6.8 0.54 10.7 0.5 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 1 RRM_1 PF00076.20 MSTRG.6626.2_2 - 4.1e-28 96.9 0.1 7.7e-15 54.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 MSTRG.6626.2_2 - 3.4e-10 39.5 0.1 0.00095 18.6 0.0 2.2 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 MSTRG.6626.2_2 - 7e-06 25.7 0.3 0.0056 16.4 0.1 2.3 2 0 0 2 2 2 2 Occluded RNA-recognition motif RNA_bind PF08675.9 MSTRG.6626.2_2 - 2.8e-05 23.9 0.0 0.047 13.6 0.0 2.4 2 0 0 2 2 2 2 RNA binding domain Limkain-b1 PF11608.6 MSTRG.6626.2_2 - 0.00014 21.7 0.0 0.064 13.2 0.0 2.3 1 1 1 2 2 2 2 Limkain b1 Calcipressin PF04847.10 MSTRG.6626.2_2 - 0.0023 17.5 0.5 0.095 12.3 0.1 2.7 1 1 1 2 2 2 1 Calcipressin DbpA PF03880.13 MSTRG.6626.2_2 - 0.0069 16.2 0.1 2 8.3 0.0 2.4 2 0 0 2 2 2 2 DbpA RNA binding domain RRM_7 PF16367.3 MSTRG.6626.2_2 - 0.015 15.3 0.0 0.033 14.2 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif Snf7 PF03357.19 MSTRG.26619.1_1 - 5.7e-50 169.1 20.2 9.5e-50 168.4 20.2 1.4 1 0 0 1 1 1 1 Snf7 SYF2 PF08231.10 MSTRG.26619.1_1 - 0.0093 16.2 6.5 0.0093 16.2 6.5 2.0 2 0 0 2 2 2 1 SYF2 splicing factor Exonuc_VII_L PF02601.13 MSTRG.26619.1_1 - 1.7 8.0 7.0 2.4 7.5 7.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Caskin-tail PF16632.3 MSTRG.26619.1_1 - 9.2 6.6 9.5 21 5.5 1.5 3.0 3 0 0 3 3 3 0 C-terminal region of Caskin Pkinase PF00069.23 MSTRG.10322.2_3 - 3.3e-49 167.5 0.2 4.8e-49 166.9 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.10322.2_3 - 3.6e-22 78.7 0.2 2e-21 76.3 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Forkhead PF00250.16 MSTRG.8027.1_2 - 4.8e-31 106.8 0.1 7.2e-31 106.2 0.1 1.2 1 0 0 1 1 1 1 Forkhead domain DUF2914 PF11141.6 MSTRG.5036.2_1 - 0.37 10.4 2.0 0.96 9.1 2.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2914) DUF3668 PF12416.6 MSTRG.5036.2_3 - 2.3e-61 207.4 0.0 3.3e-61 206.9 0.0 1.1 1 0 0 1 1 1 1 Cep120 protein Alk_phosphatase PF00245.18 MSTRG.2609.2_3 - 1.4e-168 561.1 0.0 1.7e-168 560.8 0.0 1.1 1 0 0 1 1 1 1 Alkaline phosphatase IMUP PF15761.3 MSTRG.3601.1_2 - 6.7 7.3 7.7 17 6.1 7.7 1.6 1 0 0 1 1 1 0 Immortalisation up-regulated protein Linker_histone PF00538.17 MSTRG.2613.3_3 - 1.8e-43 146.6 1.2 2.6e-15 56.4 1.1 3.7 3 0 0 3 3 3 3 linker histone H1 and H5 family Stork_head PF10264.7 MSTRG.2613.3_3 - 3.2e-05 23.8 0.0 0.44 10.6 0.0 3.3 3 0 0 3 3 3 2 Winged helix Storkhead-box1 domain Hexokinase_2 PF03727.14 MSTRG.23215.1_2 - 3e-173 573.5 0.6 3.3e-89 298.3 0.1 2.2 2 0 0 2 2 2 2 Hexokinase Hexokinase_1 PF00349.19 MSTRG.23215.1_2 - 2.1e-145 481.4 2.6 6.6e-75 251.3 0.2 2.2 2 0 0 2 2 2 2 Hexokinase SPOC PF07744.11 MSTRG.23215.1_2 - 0.017 14.9 0.0 7.3 6.4 0.0 2.4 2 0 0 2 2 2 0 SPOC domain CSD PF00313.20 MSTRG.23215.1_2 - 0.16 11.7 0.0 3 7.6 0.0 2.4 2 0 0 2 2 2 0 'Cold-shock' DNA-binding domain L27 PF02828.14 MSTRG.28239.1_3 - 7.8e-12 44.6 1.1 1e-11 44.3 1.1 1.2 1 0 0 1 1 1 1 L27 domain TUDOR PF00567.22 MSTRG.27317.3_2 - 1.1e-24 86.7 0.0 1.8e-24 86.0 0.0 1.4 1 0 0 1 1 1 1 Tudor domain KH_1 PF00013.27 MSTRG.27317.3_2 - 5.5e-10 38.8 0.0 9.7e-10 38.0 0.0 1.4 1 0 0 1 1 1 1 KH domain Agenet PF05641.10 MSTRG.27317.3_2 - 0.0072 16.7 0.3 0.018 15.4 0.3 1.6 1 0 0 1 1 1 1 Agenet domain DUF2363 PF10155.7 MSTRG.1155.1_1 - 5.7e-55 184.7 6.3 9.1e-55 184.0 6.3 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2363) DUF4203 PF13886.4 MSTRG.20066.1_2 - 3.6e-44 150.7 25.1 6.3e-44 149.9 25.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) DUF2755 PF10954.6 MSTRG.20066.1_2 - 0.051 13.4 6.2 0.061 13.1 2.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2755) IQ PF00612.25 MSTRG.28949.1_3 - 5.5e-19 66.0 17.0 2.2e-05 23.7 0.7 4.2 4 0 0 4 4 4 4 IQ calmodulin-binding motif Na_K-ATPase PF00287.16 MSTRG.3868.2_1 - 1.4e-112 375.4 1.3 2.1e-112 374.8 1.3 1.3 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain HLH PF00010.24 MSTRG.23632.2_3 - 4.2e-10 39.3 0.9 8.4e-10 38.3 0.9 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain G-patch PF01585.21 MSTRG.14016.1_3 - 1.4e-17 63.2 2.9 2.7e-17 62.3 2.9 1.5 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.20 MSTRG.14016.1_3 - 4.4e-15 55.1 0.0 1.5e-06 27.8 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP PF00641.16 MSTRG.14016.1_3 - 2.8e-10 39.2 1.5 6.3e-10 38.1 1.5 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others G-patch_2 PF12656.5 MSTRG.14016.1_3 - 1.8e-07 31.0 0.6 1.8e-07 31.0 0.6 2.1 2 0 0 2 2 2 1 G-patch domain zf-C2H2_jaz PF12171.6 MSTRG.14016.1_3 - 0.056 13.7 0.1 0.14 12.4 0.1 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.4 MSTRG.14016.1_3 - 0.059 14.1 0.1 0.27 12.1 0.1 2.2 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2HE PF16278.3 MSTRG.14016.1_3 - 0.11 12.8 0.3 3.3 8.1 0.3 2.9 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2 PF00096.24 MSTRG.14016.1_3 - 2.5 8.6 5.9 0.39 11.1 0.2 2.8 2 1 1 3 3 3 0 Zinc finger, C2H2 type Pkinase_Tyr PF07714.15 MSTRG.14734.1_1 - 4.7e-13 48.9 0.0 5.6e-13 48.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.14734.1_1 - 0.0056 15.9 0.0 0.0077 15.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Serine_rich PF08824.8 MSTRG.14734.1_1 - 0.14 12.1 0.0 0.18 11.7 0.0 1.1 1 0 0 1 1 1 0 Serine rich protein interaction domain Glyco_transf_7N PF13733.4 MSTRG.20289.1_2 - 1.8e-55 186.1 0.0 2.9e-55 185.5 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.12 MSTRG.20289.1_2 - 8.8e-31 105.3 0.0 1.5e-30 104.5 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase RRM_1 PF00076.20 MSTRG.10938.1_3 - 3e-29 100.5 0.0 1.1e-14 53.8 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mito_carr PF00153.25 MSTRG.1031.1_3 - 1.6e-59 197.7 4.5 5.5e-20 71.0 0.8 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein RhoGEF PF00621.18 MSTRG.25818.1_3 - 2.1e-37 129.0 0.1 3.2e-37 128.4 0.1 1.3 1 0 0 1 1 1 1 RhoGEF domain Dimer_Tnp_hAT PF05699.12 MSTRG.2178.1_1 - 5.3e-09 35.6 0.0 7.4e-09 35.2 0.0 1.2 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Auto_anti-p27 PF06677.10 MSTRG.2178.1_3 - 0.2 11.7 3.2 0.6 10.2 0.1 2.7 3 0 0 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) GATA PF00320.25 MSTRG.13623.1_2 - 6e-29 99.2 19.1 2.3e-14 52.5 5.9 2.6 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.10 MSTRG.13623.1_2 - 0.0022 17.3 11.7 0.043 13.2 0.7 2.4 2 0 0 2 2 2 2 TFIIB zinc-binding DUF2387 PF09526.8 MSTRG.13623.1_2 - 0.26 11.3 6.1 9.5 6.3 0.8 3.3 1 1 2 3 3 3 0 Probable metal-binding protein (DUF2387) Elf1 PF05129.11 MSTRG.13623.1_2 - 0.79 9.7 3.8 19 5.2 0.6 2.6 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like DZR PF12773.5 MSTRG.13623.1_2 - 1.2 9.1 12.0 1.2 9.1 2.3 2.9 1 1 2 3 3 3 0 Double zinc ribbon Auto_anti-p27 PF06677.10 MSTRG.13623.1_2 - 1.3 9.1 8.8 2.5 8.2 0.4 2.6 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Prim_Zn_Ribbon PF08273.10 MSTRG.13623.1_2 - 4.4 7.6 15.3 0.56 10.5 2.7 3.0 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase Bromodomain PF00439.23 MSTRG.23106.1_2 - 5.9e-104 340.2 14.2 9.7e-20 70.3 0.1 6.4 6 0 0 6 6 6 6 Bromodomain BAH PF01426.16 MSTRG.23106.1_2 - 3.9e-43 146.0 5.0 1.6e-22 79.5 1.3 2.8 2 0 0 2 2 2 2 BAH domain HMG_box PF00505.17 MSTRG.23106.1_2 - 1.8e-14 53.8 1.4 3.6e-14 52.8 0.1 2.2 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.8 MSTRG.23106.1_2 - 1.4e-09 38.2 0.2 3.8e-09 36.9 0.2 1.7 1 0 0 1 1 1 1 HMG-box domain TEX12 PF15219.4 MSTRG.23106.1_2 - 0.72 10.1 5.6 12 6.1 0.1 4.0 3 1 0 3 3 3 0 Testis-expressed 12 zf-C2H2 PF00096.24 MSTRG.5445.1_1 - 2.4e-33 112.6 78.5 1.8e-05 24.8 1.1 10.1 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.5445.1_1 - 5.6e-28 95.1 85.0 0.00052 20.5 0.1 11.2 11 0 0 11 11 11 9 C2H2-type zinc finger zf-met PF12874.5 MSTRG.5445.1_1 - 1.3e-25 88.9 56.7 0.00028 21.0 1.0 10.0 9 0 0 9 9 9 8 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.4 MSTRG.5445.1_1 - 1.6e-21 75.6 75.1 4.3e-07 30.0 1.0 12.0 13 0 0 13 13 13 6 Zinc-finger double domain zf-C2H2_jaz PF12171.6 MSTRG.5445.1_1 - 2e-20 72.4 41.3 0.0015 18.7 0.1 9.5 9 0 0 9 9 9 7 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 MSTRG.5445.1_1 - 0.00047 19.9 68.5 0.29 11.0 1.6 10.4 10 0 0 10 10 10 6 C2H2-type zinc finger DUF3268 PF11672.6 MSTRG.5445.1_1 - 0.0072 16.5 19.3 0.38 11.0 0.5 4.3 4 0 0 4 4 4 3 zinc-finger-containing domain zf-C2H2_11 PF16622.3 MSTRG.5445.1_1 - 0.042 13.5 55.3 0.83 9.3 2.9 8.9 9 0 0 9 9 9 0 zinc-finger C2H2-type BolA PF01722.16 MSTRG.5445.1_1 - 0.34 11.1 5.8 2.1 8.5 0.0 3.9 4 0 0 4 4 4 0 BolA-like protein zf-C2H2_9 PF16293.3 MSTRG.5445.1_1 - 0.46 10.2 6.0 8.7 6.1 0.2 4.3 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) LRR_8 PF13855.4 MSTRG.15852.1_1 - 5.1e-30 102.9 5.8 3.7e-12 45.7 1.4 2.8 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.5 MSTRG.15852.1_1 - 4.2e-13 49.1 2.7 3.1e-08 33.6 1.3 2.7 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) Ig_3 PF13927.4 MSTRG.15852.1_1 - 7.4e-13 48.8 0.4 1.8e-12 47.5 0.1 1.9 2 0 0 2 2 1 1 Immunoglobulin domain I-set PF07679.14 MSTRG.15852.1_1 - 6.8e-11 42.0 0.0 1.2e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.15852.1_1 - 1.9e-07 31.2 1.2 8.3e-07 29.1 0.0 2.6 4 0 0 4 4 3 1 Immunoglobulin domain LRR_1 PF00560.31 MSTRG.15852.1_1 - 1e-05 25.2 0.7 4.8 7.9 0.0 4.8 3 1 1 4 4 4 2 Leucine Rich Repeat ig PF00047.23 MSTRG.15852.1_1 - 0.00011 22.1 0.0 0.00045 20.2 0.0 2.1 1 1 0 1 1 1 1 Immunoglobulin domain LRR_5 PF13306.4 MSTRG.15852.1_1 - 0.00031 20.6 0.0 0.00074 19.3 0.0 1.5 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) V-set PF07686.15 MSTRG.15852.1_1 - 0.0023 17.9 0.0 0.049 13.7 0.0 2.4 1 1 0 1 1 1 1 Immunoglobulin V-set domain LRR_9 PF14580.4 MSTRG.15852.1_1 - 0.0033 16.8 0.0 0.64 9.4 0.0 2.2 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.4 MSTRG.15852.1_1 - 0.035 14.0 2.9 1.2 9.3 0.1 3.8 4 0 0 4 4 4 0 Leucine Rich repeat C2-set_2 PF08205.10 MSTRG.15852.1_1 - 0.08 12.9 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Ras PF00071.20 MSTRG.20874.1_2 - 2.3e-49 167.0 0.0 3.3e-49 166.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.20874.1_2 - 6e-32 110.3 0.0 8.8e-32 109.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.20874.1_2 - 3e-14 52.7 0.0 4.8e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 MSTRG.20874.1_2 - 1.7e-07 30.7 0.0 2.3e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 MSTRG.20874.1_2 - 4.7e-06 26.2 0.1 0.00012 21.5 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.8 MSTRG.20874.1_2 - 2.4e-05 23.7 0.0 3.4e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 MSTRG.20874.1_2 - 3.5e-05 23.7 0.0 5.1e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.18 MSTRG.20874.1_2 - 0.0029 16.7 0.1 0.015 14.4 0.0 2.0 1 1 1 2 2 2 1 G-protein alpha subunit PduV-EutP PF10662.7 MSTRG.20874.1_2 - 0.019 14.6 0.0 0.029 14.0 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation TniB PF05621.9 MSTRG.20874.1_2 - 0.025 13.7 0.0 0.038 13.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein AAA_24 PF13479.4 MSTRG.20874.1_2 - 0.097 12.2 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.14 MSTRG.20874.1_2 - 0.17 11.7 0.0 6.7 6.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AIG1 PF04548.14 MSTRG.24120.1_1 - 2.4e-11 43.2 0.2 3.9e-11 42.5 0.2 1.2 1 0 0 1 1 1 1 AIG1 family SWIB PF02201.16 MSTRG.2723.1_2 - 4.8e-24 83.9 0.2 9.9e-24 82.9 0.2 1.6 1 0 0 1 1 1 1 SWIB/MDM2 domain DUF1771 PF08590.8 MSTRG.11400.1_3 - 1.7e-16 60.2 10.9 2.3e-16 59.7 8.8 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) AAA_33 PF13671.4 MSTRG.11400.1_3 - 9.9e-16 58.0 0.0 3e-15 56.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain Smr PF01713.19 MSTRG.11400.1_3 - 3.2e-11 43.3 0.0 1.2e-10 41.5 0.0 2.1 1 0 0 1 1 1 1 Smr domain CUE PF02845.14 MSTRG.11400.1_3 - 2e-10 40.0 2.5 2.7e-06 26.8 0.2 3.1 3 0 0 3 3 3 2 CUE domain AAA_18 PF13238.4 MSTRG.11400.1_3 - 1.7e-05 25.2 0.1 9.2e-05 22.8 0.0 2.4 3 0 0 3 3 1 1 AAA domain Zeta_toxin PF06414.10 MSTRG.11400.1_3 - 9.6e-05 21.6 0.0 0.00021 20.5 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.4 MSTRG.11400.1_3 - 0.00078 19.7 0.0 0.0035 17.6 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.27 MSTRG.11400.1_3 - 0.0025 18.1 0.0 0.0071 16.6 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.4 MSTRG.11400.1_3 - 0.0042 16.7 0.0 0.068 12.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.12 MSTRG.11400.1_3 - 0.0062 16.4 0.0 0.021 14.7 0.0 2.0 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.4 MSTRG.11400.1_3 - 0.02 15.0 0.0 0.096 12.8 0.0 2.2 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.4 MSTRG.11400.1_3 - 0.029 14.5 0.0 0.12 12.5 0.0 2.2 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.4 MSTRG.11400.1_3 - 0.034 13.7 0.0 0.072 12.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Mg_chelatase PF01078.19 MSTRG.11400.1_3 - 0.035 13.4 0.1 0.12 11.6 0.1 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ABC_tran PF00005.25 MSTRG.11400.1_3 - 0.041 14.3 0.0 0.13 12.7 0.0 1.9 1 0 0 1 1 1 0 ABC transporter TsaE PF02367.15 MSTRG.11400.1_3 - 0.041 13.8 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.10 MSTRG.11400.1_3 - 0.055 13.3 0.2 0.17 11.7 0.0 1.9 2 0 0 2 2 1 0 NACHT domain KTI12 PF08433.8 MSTRG.11400.1_3 - 0.086 12.1 0.0 0.2 10.9 0.0 1.6 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_17 PF13207.4 MSTRG.11400.1_3 - 0.093 13.0 0.4 0.58 10.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain CPT PF07931.10 MSTRG.11400.1_3 - 0.11 12.2 0.0 0.29 10.8 0.0 1.7 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein p450 PF00067.20 MSTRG.10416.3_3 - 8.8e-41 140.0 0.0 2.3e-40 138.6 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 Asparaginase_II PF06089.10 MSTRG.10416.3_3 - 0.095 11.6 0.1 0.14 11.0 0.1 1.2 1 0 0 1 1 1 0 L-asparaginase II UEV PF05743.11 MSTRG.22103.1_2 - 1.9e-45 153.5 0.4 3.7e-45 152.6 0.2 1.6 2 0 0 2 2 1 1 UEV domain Vps23_core PF09454.8 MSTRG.22103.1_2 - 1.7e-27 95.0 0.1 3.3e-27 94.1 0.1 1.5 1 0 0 1 1 1 1 Vps23 core domain DUF3450 PF11932.6 MSTRG.22103.1_2 - 0.00063 19.0 6.6 0.0011 18.2 6.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) APG6 PF04111.10 MSTRG.22103.1_2 - 0.0011 18.4 3.3 0.0016 17.8 3.3 1.2 1 0 0 1 1 1 1 Autophagy protein Apg6 UQ_con PF00179.24 MSTRG.22103.1_2 - 0.0089 15.6 0.3 0.017 14.6 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme GPS2_interact PF15784.3 MSTRG.22103.1_2 - 0.011 16.3 6.3 0.024 15.2 6.3 1.5 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain SlyX PF04102.10 MSTRG.22103.1_2 - 0.024 15.1 3.7 0.024 15.1 3.7 3.0 2 1 1 3 3 3 0 SlyX Paralemmin PF03285.13 MSTRG.22103.1_2 - 0.099 12.1 2.8 0.14 11.7 2.8 1.1 1 0 0 1 1 1 0 Paralemmin ERM PF00769.17 MSTRG.22103.1_2 - 0.21 11.2 11.4 0.32 10.7 11.4 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF342 PF03961.11 MSTRG.22103.1_2 - 0.34 9.3 1.6 0.51 8.8 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Fzo_mitofusin PF04799.11 MSTRG.22103.1_2 - 0.35 10.2 3.1 0.65 9.4 3.1 1.4 1 0 0 1 1 1 0 fzo-like conserved region IncA PF04156.12 MSTRG.22103.1_2 - 0.42 10.3 6.8 0.66 9.6 6.8 1.2 1 0 0 1 1 1 0 IncA protein DUF1640 PF07798.9 MSTRG.22103.1_2 - 0.58 10.1 7.3 1 9.3 7.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) Spc7 PF08317.9 MSTRG.22103.1_2 - 0.86 8.3 8.8 1.3 7.7 8.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Laminin_II PF06009.10 MSTRG.22103.1_2 - 0.88 9.5 6.7 1.4 8.8 4.1 2.1 2 0 0 2 2 2 0 Laminin Domain II DUF724 PF05266.12 MSTRG.22103.1_2 - 1.2 8.8 5.5 1.9 8.2 5.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) FlaC_arch PF05377.9 MSTRG.22103.1_2 - 2.1 8.7 8.0 5.8 7.3 0.4 2.4 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DUF4140 PF13600.4 MSTRG.22103.1_2 - 2.8 8.3 5.6 14 6.0 5.6 2.0 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) NPV_P10 PF05531.10 MSTRG.22103.1_2 - 2.8 8.3 4.8 4.1 7.8 3.4 1.9 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein ADIP PF11559.6 MSTRG.22103.1_2 - 3.1 7.7 8.7 5.1 7.0 8.7 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Spc24 PF08286.9 MSTRG.22103.1_2 - 3.3 7.9 10.3 0.97 9.6 3.3 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DivIC PF04977.13 MSTRG.22103.1_2 - 5.7 6.7 12.0 1.6 8.4 1.7 2.4 1 1 1 2 2 2 0 Septum formation initiator Prefoldin PF02996.15 MSTRG.22103.1_2 - 7.8 6.3 9.0 4.9 6.9 1.5 2.3 1 1 1 2 2 2 0 Prefoldin subunit DUF3552 PF12072.6 MSTRG.22103.1_2 - 9.3 5.5 12.6 14 4.9 12.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) MFS_1 PF07690.14 MSTRG.14576.2_2 - 1.1e-43 149.4 41.0 1.7e-36 125.8 32.0 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 MSTRG.14576.2_2 - 4.8e-08 32.2 2.8 4.8e-08 32.2 2.8 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter DUF2070 PF09843.7 MSTRG.14576.2_2 - 9.2 4.3 11.5 0.094 10.8 2.3 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2070) Lamp PF01299.15 MSTRG.10347.2_1 - 3.9e-107 358.3 20.8 7.6e-99 331.1 15.9 2.0 1 1 1 2 2 2 2 Lysosome-associated membrane glycoprotein (Lamp) ATP-synt_S1 PF05827.10 MSTRG.10347.2_1 - 1.4e-08 34.5 5.0 6.2e-08 32.4 0.4 2.4 2 0 0 2 2 2 2 Vacuolar ATP synthase subunit S1 (ATP6S1) NAD_binding_11 PF14833.4 MSTRG.28676.1_2 - 3.6e-18 65.8 0.0 4e-18 65.7 0.0 1.0 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase LIM PF00412.20 MSTRG.25867.2_1 - 5.5e-29 100.0 28.1 1.1e-11 44.7 4.3 3.6 3 0 0 3 3 3 3 LIM domain FERM_M PF00373.16 MSTRG.7299.2_3 - 1.2e-43 148.1 0.0 5.2e-43 146.1 0.0 2.1 2 1 0 2 2 2 1 FERM central domain PH PF00169.27 MSTRG.7299.2_3 - 4.2e-11 43.2 0.0 1e-10 41.9 0.0 1.7 1 0 0 1 1 1 1 PH domain FERM_N PF09379.8 MSTRG.7299.2_3 - 0.00053 19.7 0.0 0.0012 18.7 0.0 1.6 1 0 0 1 1 1 1 FERM N-terminal domain PH_11 PF15413.4 MSTRG.7299.2_3 - 0.012 15.9 1.6 0.2 12.0 0.9 2.9 2 1 0 2 2 2 0 Pleckstrin homology domain PH_8 PF15409.4 MSTRG.7299.2_3 - 0.055 13.6 0.0 0.14 12.3 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain FBPase PF00316.18 MSTRG.4950.2_2 - 2.7e-55 186.7 0.0 4e-55 186.2 0.0 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.23 MSTRG.4950.2_2 - 0.046 13.1 0.0 0.12 11.8 0.0 1.6 2 0 0 2 2 2 0 Inositol monophosphatase family C2 PF00168.28 MSTRG.26576.1_1 - 7.2e-16 58.2 0.0 1.7e-15 57.1 0.0 1.6 2 0 0 2 2 2 1 C2 domain DUF4517 PF15006.4 MSTRG.25837.1_3 - 5.5e-52 175.9 0.0 7.5e-52 175.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4517) Peptidase_C26 PF07722.11 MSTRG.1933.1_1 - 9.5e-25 87.5 0.0 2.2e-24 86.3 0.0 1.6 1 1 0 1 1 1 1 Peptidase C26 GATase PF00117.26 MSTRG.1933.1_1 - 7e-11 42.1 0.0 1.2e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SLAIN PF15301.4 MSTRG.23883.2_3 - 2.4e-115 386.1 46.5 8.7e-76 255.8 13.7 3.3 1 1 1 2 2 2 2 SLAIN motif-containing family WD40 PF00400.30 MSTRG.9366.1_1 - 8.5e-28 95.9 11.2 5.3e-11 42.8 0.3 6.5 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.9366.1_1 - 8.7e-08 32.2 0.1 0.06 13.5 0.0 5.2 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 MSTRG.9366.1_1 - 6.4e-05 21.9 0.8 0.57 8.9 0.0 4.0 2 1 3 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein TruB_C PF09142.9 MSTRG.9366.1_1 - 0.00059 19.4 0.0 0.24 11.1 0.0 2.8 2 0 0 2 2 2 2 tRNA Pseudouridine synthase II, C terminal eIF2A PF08662.9 MSTRG.9366.1_1 - 0.0023 17.7 0.2 1.4 8.6 0.2 3.4 2 2 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.10 MSTRG.9366.1_1 - 0.093 12.6 0.7 46 4.0 0.0 4.3 4 1 0 4 4 4 0 WD40-like Beta Propeller Repeat zf-Sec23_Sec24 PF04810.13 MSTRG.387.5_2 - 1.1e-14 54.0 8.5 2.9e-14 52.7 8.5 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_trunk PF04811.13 MSTRG.387.5_2 - 9.1e-10 38.4 0.0 1.2e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain GSHPx PF00255.17 MSTRG.14013.1_3 - 7.9e-38 128.2 0.0 1.1e-37 127.7 0.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase EF-hand_4 PF12763.5 MSTRG.23547.2_1 - 6.9e-40 135.1 0.0 2e-21 75.7 0.0 3.4 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.30 MSTRG.23547.2_1 - 8.9e-08 31.0 2.4 0.018 14.5 0.1 4.5 5 0 0 5 5 4 2 EF hand EF-hand_6 PF13405.4 MSTRG.23547.2_1 - 2.3e-05 23.8 2.4 1.7 8.7 0.2 4.5 4 0 0 4 4 4 2 EF-hand domain Reo_sigmaC PF04582.10 MSTRG.23547.2_1 - 0.0015 17.9 15.9 0.096 11.9 8.0 2.1 1 1 1 2 2 2 2 Reovirus sigma C capsid protein EF-hand_7 PF13499.4 MSTRG.23547.2_1 - 0.0016 18.7 1.5 2 8.8 0.1 4.2 3 2 1 4 4 4 2 EF-hand domain pair DUF4201 PF13870.4 MSTRG.23547.2_1 - 0.031 13.8 24.7 0.069 12.7 24.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) ERM PF00769.17 MSTRG.23547.2_1 - 0.034 13.8 51.5 8.1 6.1 51.5 2.2 1 1 0 1 1 1 0 Ezrin/radixin/moesin family EzrA PF06160.10 MSTRG.23547.2_1 - 0.063 11.3 27.7 0.12 10.4 27.7 1.3 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA EF-hand_8 PF13833.4 MSTRG.23547.2_1 - 0.097 12.3 3.4 0.12 12.0 0.3 2.5 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.23547.2_1 - 0.15 11.5 3.4 0.86 9.1 0.2 2.5 2 0 0 2 2 2 0 EF hand DUF3584 PF12128.6 MSTRG.23547.2_1 - 0.24 8.7 37.7 0.37 8.1 37.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) BRE1 PF08647.9 MSTRG.23547.2_1 - 1.3 9.0 33.4 0.5 10.4 12.3 2.7 1 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase FUSC PF04632.10 MSTRG.23547.2_1 - 1.9 6.8 11.6 3.2 6.1 11.6 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family Lebercilin PF15619.4 MSTRG.23547.2_1 - 2.4 7.6 40.3 5.4 6.5 40.0 1.7 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease GAS PF13851.4 MSTRG.23547.2_1 - 2.5 7.3 34.1 23 4.1 34.0 2.2 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding IncA PF04156.12 MSTRG.23547.2_1 - 3.8 7.1 57.8 0.44 10.2 35.3 3.1 2 1 1 3 3 3 0 IncA protein Fez1 PF06818.13 MSTRG.23547.2_1 - 8.3 6.7 41.0 19 5.5 21.8 2.3 1 1 1 2 2 2 0 Fez1 APG6 PF04111.10 MSTRG.23547.2_1 - 9.3 5.4 52.2 0.012 14.9 25.9 2.7 2 1 1 3 3 2 0 Autophagy protein Apg6 Spc7 PF08317.9 MSTRG.23547.2_1 - 9.7 4.8 50.0 0.15 10.8 21.0 2.7 2 1 1 3 3 3 0 Spc7 kinetochore protein UIM PF02809.18 MSTRG.23547.2_3 - 0.98 9.4 6.2 0.69 9.8 3.6 2.1 2 0 0 2 2 2 0 Ubiquitin interaction motif THAP PF05485.10 MSTRG.5107.1_1 - 0.0057 17.5 0.1 0.009 16.8 0.1 1.3 1 0 0 1 1 1 1 THAP domain THAP PF05485.10 MSTRG.5107.1_3 - 9.4e-05 23.2 0.2 0.00013 22.8 0.2 1.3 1 0 0 1 1 1 1 THAP domain HSP90 PF00183.16 MSTRG.24118.3_2 - 1.1e-98 331.2 3.8 5.7e-94 315.7 0.8 2.1 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.4 MSTRG.24118.3_2 - 5.3e-10 39.1 0.1 1.1e-09 38.1 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.24 MSTRG.24118.3_2 - 9.2e-07 29.3 0.1 1.6e-06 28.5 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Wtap PF17098.3 MSTRG.24118.3_2 - 0.037 13.8 1.0 0.075 12.8 1.0 1.4 1 0 0 1 1 1 0 WTAP/Mum2p family PhoLip_ATPase_N PF16209.3 MSTRG.4957.5_3 - 3.4e-14 52.2 3.5 4.6e-14 51.8 3.5 1.2 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Pkinase PF00069.23 MSTRG.3873.3_2 - 1.5e-63 214.5 0.6 2.5e-63 213.8 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain CNH PF00780.20 MSTRG.3873.3_2 - 1.5e-54 185.3 0.0 2.4e-54 184.7 0.0 1.3 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.15 MSTRG.3873.3_2 - 1.7e-46 158.5 0.0 2.8e-46 157.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Tubulin_C PF03953.15 MSTRG.10909.2_1 - 1.7e-14 54.0 0.2 3.4e-14 53.1 0.1 1.5 2 0 0 2 2 2 1 Tubulin C-terminal domain UCH PF00443.27 MSTRG.22277.1_2 - 4.1e-47 160.7 0.6 2.5e-42 145.0 0.1 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 MSTRG.22277.1_2 - 4.3e-19 69.1 0.0 5.6e-13 49.1 0.0 3.4 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.4 MSTRG.22277.1_2 - 0.43 9.9 3.4 3.7 6.8 0.1 3.2 4 1 0 4 4 4 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase SUIM_assoc PF16619.3 MSTRG.18516.1_2 - 0.56 10.2 13.2 1.1 9.3 8.1 2.4 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Radial_spoke_3 PF06098.9 MSTRG.25573.2_3 - 7.3e-124 412.5 16.3 1.2e-123 411.9 16.3 1.2 1 0 0 1 1 1 1 Radial spoke protein 3 PET PF06297.12 MSTRG.26644.2_2 - 6e-35 119.3 0.2 9e-35 118.7 0.2 1.3 1 0 0 1 1 1 1 PET Domain LIM PF00412.20 MSTRG.26644.2_2 - 8.3e-05 22.6 4.5 0.00013 22.0 3.0 2.1 1 1 0 1 1 1 1 LIM domain DUF3439 PF11921.6 MSTRG.1196.2_1 - 0.0027 17.5 4.2 0.0043 16.9 4.2 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF3439) AIRS_C PF02769.20 MSTRG.25160.1_1 - 6.3e-30 104.2 0.1 9.1e-30 103.7 0.1 1.2 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.22 MSTRG.25160.1_1 - 3.7e-10 40.2 0.3 7.9e-10 39.1 0.3 1.5 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain 7tm_1 PF00001.19 MSTRG.7060.2_1 - 2.7e-43 148.0 33.0 6.8e-43 146.7 33.0 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 MSTRG.7060.2_1 - 4.8e-05 22.7 26.8 6.7e-05 22.3 26.8 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx HMG_box_5 PF14887.4 MSTRG.10404.3_3 - 3.1e-38 129.5 21.9 3.6e-31 106.8 4.5 4.0 4 0 0 4 4 4 3 HMG (high mobility group) box 5 HMG_box PF00505.17 MSTRG.10404.3_3 - 1.1e-36 125.0 53.7 4.9e-17 62.0 9.1 6.6 6 1 1 7 7 7 5 HMG (high mobility group) box HMG_box_2 PF09011.8 MSTRG.10404.3_3 - 4.9e-14 52.5 46.7 4.5e-05 23.8 0.2 6.6 6 1 1 7 7 7 5 HMG-box domain DUF4473 PF14747.4 MSTRG.10404.3_3 - 0.0032 17.8 0.1 0.0032 17.8 0.1 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4473) NOA36 PF06524.10 MSTRG.10404.3_3 - 5.2 6.2 19.6 12 5.0 19.6 1.6 1 0 0 1 1 1 0 NOA36 protein bZIP_1 PF00170.19 MSTRG.10404.3_3 - 8.8 6.4 10.0 14 5.8 2.6 3.0 2 0 0 2 2 2 0 bZIP transcription factor La PF05383.15 MSTRG.947.1_1 - 1.5e-20 72.8 0.1 3.6e-20 71.6 0.1 1.7 1 0 0 1 1 1 1 La domain MRJP PF03022.14 MSTRG.947.1_1 - 0.15 11.3 0.3 0.24 10.6 0.3 1.2 1 0 0 1 1 1 0 Major royal jelly protein FLO_LFY PF01698.14 MSTRG.947.1_1 - 2.6 7.0 8.7 6.2 5.8 8.7 1.5 1 0 0 1 1 1 0 Floricaula / Leafy protein TolA_bind_tri PF16331.3 MSTRG.947.1_3 - 0.53 10.3 3.8 1.2 9.1 3.8 1.5 1 0 0 1 1 1 0 TolA binding protein trimerisation Astacin PF01400.22 MSTRG.13283.2_1 - 4.2e-56 189.5 0.2 5.6e-56 189.0 0.2 1.1 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) IBN_N PF03810.17 MSTRG.14628.2_1 - 2.3e-12 46.5 0.1 5.4e-12 45.3 0.1 1.7 1 0 0 1 1 1 1 Importin-beta N-terminal domain WD40 PF00400.30 MSTRG.27543.7_1 - 2.6e-46 154.5 33.3 5.2e-07 30.1 0.2 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.6 MSTRG.27543.7_1 - 2.8e-13 49.2 12.7 0.04 12.4 0.1 6.4 2 1 3 6 6 6 6 Nucleoporin Nup120/160 F-box-like PF12937.5 MSTRG.27543.7_1 - 5.8e-13 48.4 1.7 1.3e-12 47.3 1.7 1.6 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.5 MSTRG.27543.7_1 - 1e-12 48.0 7.2 0.024 14.8 0.1 6.7 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.31 MSTRG.27543.7_1 - 5.7e-09 35.5 0.3 1.1e-08 34.6 0.3 1.5 1 0 0 1 1 1 1 F-box domain PQQ_2 PF13360.4 MSTRG.27543.7_1 - 8.9e-05 22.1 3.1 0.00023 20.7 1.4 2.6 2 1 0 2 2 2 1 PQQ-like domain Ge1_WD40 PF16529.3 MSTRG.27543.7_1 - 0.0029 16.5 9.6 2 7.2 0.2 4.7 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein CDtoxinA PF03498.12 MSTRG.27543.7_1 - 0.0099 15.3 1.3 0.41 10.1 0.2 2.8 2 1 1 3 3 3 1 Cytolethal distending toxin A/C domain Hira PF07569.9 MSTRG.27543.7_1 - 0.1 12.2 1.6 25 4.4 0.0 3.9 2 2 2 4 4 4 0 TUP1-like enhancer of split PALB2_WD40 PF16756.3 MSTRG.27543.7_1 - 0.1 11.3 6.7 0.35 9.6 0.2 4.1 2 2 3 5 5 5 0 Partner and localizer of BRCA2 WD40 domain Neur_chan_LBD PF02931.21 MSTRG.3871.2_2 - 2.5e-68 229.6 0.4 3.9e-68 229.0 0.4 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 MSTRG.3871.2_2 - 2.1e-62 211.2 0.4 2.8e-62 210.8 0.4 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Sulfatase PF00884.21 MSTRG.15924.2_3 - 2.5e-47 161.6 0.0 3.6e-47 161.1 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.20 MSTRG.15924.2_3 - 1.3e-06 28.1 0.1 0.00023 20.8 0.0 2.3 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.15 MSTRG.15924.2_3 - 0.012 14.1 0.1 0.025 13.1 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF229) GTP_EFTU PF00009.25 MSTRG.2167.1_1 - 3e-46 157.3 0.0 6.2e-46 156.3 0.0 1.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.15 MSTRG.2167.1_1 - 8.5e-31 106.4 1.7 1.1e-30 106.1 0.1 2.1 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.23 MSTRG.2167.1_1 - 3.8e-06 27.1 0.0 8.6e-06 25.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 PAM2 PF07145.13 MSTRG.2167.1_1 - 0.00012 21.4 12.6 0.0027 17.1 2.2 3.1 2 1 1 3 3 3 2 Ataxin-2 C-terminal region MMR_HSR1 PF01926.21 MSTRG.2167.1_1 - 0.0013 18.6 0.1 0.0053 16.7 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase Arrestin_N PF00339.27 MSTRG.22419.1_2 - 9.4e-07 28.9 0.0 9.5e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain zf-H2C2_2 PF13465.4 MSTRG.23888.1_2 - 2.2e-20 72.0 36.4 9.1e-07 28.9 0.5 6.5 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.23888.1_2 - 3.5e-11 42.8 35.6 0.0069 17.0 2.0 5.7 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2 PF00096.24 MSTRG.23888.1_2 - 1.7e-10 40.6 37.7 0.0024 18.1 2.1 5.5 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2HE PF16278.3 MSTRG.23888.1_2 - 1.3e-05 25.4 16.6 0.00014 22.1 1.8 4.1 3 2 1 4 4 4 3 C2HE / C2H2 / C2HC zinc-binding finger GAGA PF09237.9 MSTRG.23888.1_2 - 0.014 15.1 4.1 8.7 6.1 0.1 3.8 1 1 2 3 3 3 0 GAGA factor zf-C2H2_6 PF13912.4 MSTRG.23888.1_2 - 0.023 14.5 0.6 0.023 14.5 0.6 5.8 5 1 0 5 5 5 0 C2H2-type zinc finger BolA PF01722.16 MSTRG.23888.1_2 - 0.067 13.3 2.4 0.77 10.0 0.1 2.6 2 0 0 2 2 2 0 BolA-like protein zf-C2H2_jaz PF12171.6 MSTRG.23888.1_2 - 0.069 13.3 14.7 3.4 8.0 0.1 4.7 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 MSTRG.23888.1_2 - 0.15 11.7 0.2 0.15 11.7 0.2 4.1 5 0 0 5 5 5 0 zinc-finger C2H2-type ELO PF01151.16 MSTRG.24026.1_3 - 3.4e-65 219.9 20.0 5.3e-65 219.3 20.0 1.3 1 0 0 1 1 1 1 GNS1/SUR4 family LRR_8 PF13855.4 MSTRG.22943.1_2 - 8.2e-25 86.2 28.1 5.3e-10 38.8 6.2 3.9 3 0 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.5 MSTRG.22943.1_2 - 4.9e-15 55.2 35.3 8.5e-07 29.0 0.3 6.9 3 1 2 7 7 7 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 MSTRG.22943.1_2 - 0.00084 18.8 13.7 0.25 10.7 1.4 4.1 2 1 1 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.31 MSTRG.22943.1_2 - 0.041 14.2 23.3 29 5.5 0.9 8.8 7 2 0 7 7 7 0 Leucine Rich Repeat JmjC PF02373.20 MSTRG.12441.2_1 - 8.5e-29 100.2 1.4 2.1e-28 98.9 1.4 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase TPR_1 PF00515.26 MSTRG.12441.2_1 - 2.8e-28 96.4 14.6 6e-06 25.7 0.0 8.4 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.12441.2_1 - 1.2e-15 56.1 15.2 0.0015 18.3 0.1 8.5 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.12441.2_1 - 2e-12 47.4 1.2 0.024 15.2 0.2 5.1 3 1 1 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.12441.2_1 - 3.1e-12 45.6 13.9 0.03 14.4 0.6 7.6 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.12441.2_1 - 6e-11 41.8 5.3 0.0037 17.4 0.0 4.7 6 0 0 6 6 4 3 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.12441.2_1 - 2.3e-10 40.5 6.2 0.36 11.0 0.1 5.5 3 2 3 6 6 6 6 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.12441.2_1 - 4.1e-07 29.4 4.2 0.11 12.0 0.0 5.8 3 2 3 6 6 6 2 TPR repeat TPR_19 PF14559.4 MSTRG.12441.2_1 - 2e-06 28.1 5.1 0.59 10.6 0.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.12441.2_1 - 4.3e-06 27.0 1.9 5.5 8.0 0.0 5.7 4 2 3 7 7 6 1 Tetratricopeptide repeat TPR_9 PF13371.4 MSTRG.12441.2_1 - 4.5e-06 26.6 0.1 0.0086 16.1 0.0 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.12441.2_1 - 0.0051 16.6 4.7 8.8 6.5 0.0 5.2 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.12441.2_1 - 0.098 13.2 7.8 11 6.7 0.3 5.9 8 0 0 8 8 5 0 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.12441.2_1 - 2.6 8.2 7.9 1.8 8.7 0.0 3.3 2 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 HbrB PF08539.9 MSTRG.9746.1_1 - 4.5e-09 36.4 0.6 6.6e-06 26.1 0.0 2.3 1 1 1 2 2 2 2 HbrB-like Bromodomain PF00439.23 MSTRG.27701.3_2 - 9.4e-43 144.1 1.2 8.4e-21 73.7 0.0 2.4 2 0 0 2 2 2 2 Bromodomain BET PF17035.3 MSTRG.27701.3_2 - 1.5e-28 98.6 0.2 3.2e-28 97.6 0.2 1.6 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation BRD4_CDT PF17105.3 MSTRG.27701.3_2 - 3.6e-24 83.9 11.9 3.6e-24 83.9 11.9 3.9 4 0 0 4 4 4 1 C-terminal domain of bromodomain protein 4 Glycos_transf_2 PF00535.24 MSTRG.13265.1_1 - 9.4e-23 80.7 0.0 1.6e-22 80.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.20 MSTRG.13265.1_1 - 6.3e-22 78.1 1.6 1.1e-21 77.2 1.6 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.4 MSTRG.13265.1_1 - 0.00066 19.5 0.0 0.001 18.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.12 MSTRG.13265.1_1 - 0.0095 15.4 0.0 0.023 14.2 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 MSTRG.13265.1_1 - 0.012 14.9 0.0 0.18 11.1 0.0 2.1 2 0 0 2 2 2 0 Glycosyltransferase like family 2 DUF2477 PF10631.7 MSTRG.16698.1_2 - 1.8 9.1 6.8 0.084 13.4 0.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2477) Fip1 PF05182.11 MSTRG.27941.3_3 - 8.2e-25 85.9 2.1 8.2e-25 85.9 2.1 1.8 2 0 0 2 2 2 1 Fip1 motif FHA PF00498.24 MSTRG.25603.2_2 - 9.5e-13 48.2 0.1 2.7e-12 46.7 0.1 1.8 1 0 0 1 1 1 1 FHA domain zf-C3HC4_3 PF13920.4 MSTRG.25603.2_2 - 3.9e-10 39.3 12.9 3.9e-10 39.3 12.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 MSTRG.25603.2_2 - 1.4e-08 34.4 15.9 1.4e-08 34.4 15.9 2.3 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.25603.2_2 - 1.8e-07 31.2 14.9 1.8e-07 31.2 14.9 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.4 MSTRG.25603.2_2 - 4.2e-07 29.6 13.7 4.2e-07 29.6 13.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 MSTRG.25603.2_2 - 5.7e-07 29.4 12.8 2.2e-06 27.6 12.8 2.1 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.5 MSTRG.25603.2_2 - 3.2e-06 27.2 8.7 3.2e-06 27.2 8.7 2.5 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.4 MSTRG.25603.2_2 - 5.6e-05 22.9 11.8 0.0004 20.2 11.2 2.7 1 1 1 2 2 2 1 RING-type zinc-finger Yop-YscD_cpl PF16697.3 MSTRG.25603.2_2 - 6.6e-05 23.0 0.0 0.00021 21.4 0.0 1.8 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-RING_5 PF14634.4 MSTRG.25603.2_2 - 0.0001 22.1 14.3 0.0001 22.1 14.3 2.2 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.4 MSTRG.25603.2_2 - 0.00021 21.0 15.7 0.00021 21.0 15.7 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.5 MSTRG.25603.2_2 - 0.00095 19.0 5.4 0.002 18.0 5.4 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger U-box PF04564.13 MSTRG.25603.2_2 - 0.015 15.3 0.0 0.074 13.1 0.0 2.2 2 0 0 2 2 2 0 U-box domain zf-RING_4 PF14570.4 MSTRG.25603.2_2 - 0.069 12.8 8.5 0.22 11.1 8.5 1.9 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain TACC PF05010.12 MSTRG.25603.2_2 - 0.13 11.9 21.4 0.27 10.8 21.4 1.5 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) zf-RING_6 PF14835.4 MSTRG.25603.2_2 - 0.54 10.0 16.1 0.72 9.6 9.2 2.9 3 0 0 3 3 2 0 zf-RING of BARD1-type protein MAT1 PF06391.11 MSTRG.25603.2_2 - 1.1 8.9 21.1 0.082 12.6 16.0 1.7 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 zf-RING_10 PF16685.3 MSTRG.25603.2_2 - 3 7.9 17.9 0.58 10.2 11.6 2.7 3 0 0 3 3 2 0 zinc RING finger of MSL2 Arf PF00025.19 MSTRG.13077.2_1 - 1.8e-45 154.4 0.2 2.4e-45 154.0 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.20 MSTRG.13077.2_1 - 1.1e-18 67.2 0.0 1.5e-18 66.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.13077.2_1 - 1.1e-15 57.8 0.0 1.6e-15 57.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.10 MSTRG.13077.2_1 - 3.2e-09 36.3 0.0 4.6e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 MSTRG.13077.2_1 - 1.3e-07 31.1 0.0 1.8e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 MSTRG.13077.2_1 - 4.7e-07 29.2 0.1 0.0001 21.5 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.21 MSTRG.13077.2_1 - 0.00011 22.1 0.0 0.00017 21.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Clathrin PF00637.18 MSTRG.13320.3_1 - 6.2e-27 94.1 0.3 6.2e-27 94.1 0.3 2.8 3 0 0 3 3 3 1 Region in Clathrin and VPS Vps39_2 PF10367.7 MSTRG.13320.3_1 - 4.5e-05 23.7 0.5 0.00014 22.1 0.5 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.7 MSTRG.13320.3_1 - 0.00073 19.7 2.9 0.04 14.1 0.0 3.3 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 TPR_7 PF13176.4 MSTRG.13320.3_1 - 0.0078 16.0 2.4 0.35 10.9 1.1 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.13320.3_1 - 0.07 13.3 3.4 0.21 11.8 0.2 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.13320.3_1 - 0.073 13.1 3.4 5.7 7.2 0.3 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat zf-rbx1 PF12678.5 MSTRG.13320.3_1 - 0.33 11.1 3.0 1.3 9.3 3.0 2.1 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3H2C3 PF17122.3 MSTRG.13320.3_1 - 2.2 8.2 5.5 0.24 11.3 0.5 2.0 2 0 0 2 2 2 0 Zinc-finger zf-RING_2 PF13639.4 MSTRG.13320.3_1 - 2.3 8.4 9.9 0.37 11.0 5.1 2.3 2 0 0 2 2 2 0 Ring finger domain zf-RING_5 PF14634.4 MSTRG.13320.3_1 - 4.6 7.1 6.8 5.5 6.9 4.8 2.3 2 1 0 2 2 2 0 zinc-RING finger domain zf-RING_11 PF17123.3 MSTRG.13320.3_1 - 9.9 5.9 9.2 0.28 10.8 2.5 2.0 2 0 0 2 2 2 0 RING-like zinc finger Cathelicidins PF00666.15 MSTRG.8458.2_3 - 7.5e-11 42.1 0.1 7.6e-05 22.8 0.1 2.4 2 0 0 2 2 2 2 Cathelicidin Cystatin PF00031.19 MSTRG.8458.2_3 - 6.1e-10 39.1 0.0 0.0016 18.5 0.1 2.3 2 0 0 2 2 2 2 Cystatin domain Tox-GHH PF15636.4 MSTRG.15986.1_3 - 2e-28 98.0 0.3 2.7e-28 97.6 0.3 1.2 1 0 0 1 1 1 1 GHH signature containing HNH/Endo VII superfamily nuclease toxin 7tm_1 PF00001.19 MSTRG.10397.1_1 - 6.8e-47 159.8 16.1 2.7e-46 157.9 16.1 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF621 PF04789.13 MSTRG.10397.1_1 - 0.015 14.4 1.3 0.02 13.9 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF621) Phage_G PF02306.13 MSTRG.10397.1_1 - 0.062 12.9 0.4 6.1 6.4 0.1 2.2 2 0 0 2 2 2 0 Major spike protein (G protein) dsrm PF00035.24 MSTRG.7795.1_2 - 4e-43 145.8 7.6 5.9e-17 62.0 0.1 3.8 4 0 0 4 4 4 3 Double-stranded RNA binding motif Pkinase PF00069.23 MSTRG.7795.1_2 - 4.8e-22 78.4 0.9 4.8e-22 78.4 0.9 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.7795.1_2 - 1.7e-11 43.8 0.2 1.7e-11 43.8 0.2 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase DND1_DSRM PF14709.5 MSTRG.7795.1_2 - 4.8e-05 23.4 3.2 0.012 15.7 0.1 3.6 3 2 0 3 3 3 2 double strand RNA binding domain from DEAD END PROTEIN 1 FTA2 PF13095.4 MSTRG.7795.1_2 - 0.13 11.7 0.0 0.13 11.7 0.0 2.1 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_Tyr PF07714.15 MSTRG.23656.2_1 - 1.7e-84 283.0 0.0 2.3e-84 282.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.23656.2_1 - 8.8e-39 133.3 0.0 1.1e-37 129.7 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain F5_F8_type_C PF00754.23 MSTRG.23656.2_1 - 6e-22 78.0 0.0 1.1e-21 77.1 0.0 1.5 1 0 0 1 1 1 1 F5/8 type C domain DUF4834 PF16118.3 MSTRG.23656.2_1 - 0.062 14.1 0.0 0.12 13.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) PID PF00640.21 MSTRG.8718.1_3 - 0.052 13.5 0.1 0.096 12.6 0.1 1.5 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) Laminin_EGF PF00053.22 MSTRG.5965.2_1 - 4.3e-28 97.1 187.7 0.0042 17.1 11.4 12.1 5 3 7 12 12 12 9 Laminin EGF domain hEGF PF12661.5 MSTRG.5965.2_1 - 1.8e-06 28.2 162.5 0.0028 18.1 4.7 15.1 13 3 1 14 14 14 7 Human growth factor-like EGF EGF_2 PF07974.11 MSTRG.5965.2_1 - 0.009 16.2 11.4 0.009 16.2 11.4 18.5 14 8 3 17 17 17 7 EGF-like domain DUF202 PF02656.13 MSTRG.5965.2_1 - 0.11 12.8 0.0 0.2 12.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF202) DUF2207 PF09972.7 MSTRG.5965.2_1 - 0.28 9.8 0.0 0.38 9.3 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SIT PF15330.4 MSTRG.5965.2_1 - 1.1 9.6 2.8 0.63 10.3 0.1 1.9 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT Choline_transpo PF04515.10 MSTRG.11567.5_2 - 1.7e-56 191.7 17.4 1.7e-56 191.7 17.4 3.0 2 1 0 3 3 3 2 Plasma-membrane choline transporter WAPL PF07814.11 MSTRG.10153.1_3 - 2.1e-105 352.3 3.2 2.9e-105 351.9 3.2 1.2 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin DUF2277 PF10041.7 MSTRG.10153.1_3 - 0.032 14.4 0.0 8.9 6.6 0.0 2.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2277) Septin PF00735.16 MSTRG.12151.3_1 - 1.6e-124 414.6 0.0 2.1e-124 414.2 0.0 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 MSTRG.12151.3_1 - 1.3e-07 31.6 0.0 3.2e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 MSTRG.12151.3_1 - 3.5e-05 23.6 0.1 0.0025 17.6 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 MSTRG.12151.3_1 - 7e-05 22.3 0.1 0.0099 15.3 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AIG1 PF04548.14 MSTRG.12151.3_1 - 0.00027 20.2 0.0 0.00052 19.3 0.0 1.4 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.21 MSTRG.12151.3_1 - 0.0013 18.7 0.2 0.2 11.6 0.0 2.7 1 1 1 2 2 2 1 Dynamin family Ras PF00071.20 MSTRG.12151.3_1 - 0.0019 17.7 0.0 0.0036 16.8 0.0 1.5 1 0 0 1 1 1 1 Ras family AAA_22 PF13401.4 MSTRG.12151.3_1 - 0.012 15.8 0.3 0.041 14.0 0.0 2.2 2 1 0 2 2 2 0 AAA domain Roc PF08477.11 MSTRG.12151.3_1 - 0.013 15.5 0.0 0.024 14.7 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.25 MSTRG.12151.3_1 - 0.025 15.0 0.0 0.054 13.9 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.4 MSTRG.12151.3_1 - 0.027 14.7 0.0 0.061 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.4 MSTRG.12151.3_1 - 0.031 13.9 0.0 0.06 12.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Gtr1_RagA PF04670.10 MSTRG.12151.3_1 - 0.08 12.1 0.3 0.55 9.4 0.0 2.1 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region PRELI PF04707.12 MSTRG.19167.2_1 - 2e-50 170.5 0.4 2.9e-50 170.0 0.4 1.2 1 0 0 1 1 1 1 PRELI-like family CRAL_TRIO PF00650.18 MSTRG.19167.2_1 - 4.4e-40 136.9 0.0 6.8e-40 136.2 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.13 MSTRG.19167.2_1 - 3.6e-05 23.7 0.1 7.6e-05 22.7 0.1 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain HTH_32 PF13565.4 MSTRG.10739.1_2 - 0.19 12.3 0.1 0.19 12.3 0.1 2.4 2 1 1 3 3 3 0 Homeodomain-like domain Zip PF02535.20 MSTRG.10739.1_2 - 0.28 10.2 1.1 0.32 10.0 1.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Adeno_terminal PF02459.13 MSTRG.10739.1_3 - 0.00016 20.1 2.2 0.00022 19.6 2.2 1.1 1 0 0 1 1 1 1 Adenoviral DNA terminal protein Lipocalin PF00061.21 MSTRG.15433.1_2 - 4.9e-18 65.6 0.0 7.4e-18 65.0 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_2 PF08212.10 MSTRG.15433.1_2 - 7.4e-07 29.1 0.1 1.3e-06 28.3 0.1 1.4 1 0 0 1 1 1 1 Lipocalin-like domain Triabin PF03973.11 MSTRG.15433.1_2 - 0.0023 17.7 0.7 0.0081 15.9 0.7 1.8 1 1 0 1 1 1 1 Triabin Galactosyl_T PF01762.19 MSTRG.8457.1_2 - 9.4e-62 208.2 0.0 1.4e-61 207.6 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase SNF2_N PF00176.21 MSTRG.4754.1_2 - 2.4e-70 236.9 2.5 5.8e-70 235.6 2.5 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.4 MSTRG.4754.1_2 - 4.6e-48 162.8 21.1 4.6e-48 162.8 21.1 3.4 3 0 0 3 3 3 1 DNA-binding domain Helicase_C PF00271.29 MSTRG.4754.1_2 - 6e-17 61.9 1.8 8e-17 61.5 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.4754.1_2 - 1.8e-07 31.2 4.6 1.1e-05 25.4 0.0 3.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.6 MSTRG.4754.1_2 - 2.5e-06 26.7 0.1 2.5e-06 26.7 0.1 3.2 3 0 0 3 3 3 2 Class II histone deacetylase complex subunits 2 and 3 Sgf11 PF08209.9 MSTRG.2486.2_1 - 3.5e-17 61.5 2.5 7.5e-17 60.4 2.5 1.6 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) SCA7 PF08313.10 MSTRG.2486.2_1 - 4.1e-05 23.2 3.3 0.00012 21.8 3.3 1.7 1 0 0 1 1 1 1 SCA7, zinc-binding domain Myb_DNA-bind_4 PF13837.4 MSTRG.9759.2_2 - 9.5e-09 35.4 0.1 2e-08 34.4 0.1 1.6 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.7 MSTRG.9759.2_2 - 7e-05 22.9 0.1 0.00016 21.8 0.1 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_3 PF12776.5 MSTRG.9759.2_2 - 0.035 14.8 0.1 0.073 13.8 0.1 1.5 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain SHMT PF00464.17 MSTRG.18696.6_3 - 1.5e-26 92.8 0.0 1.9e-26 92.5 0.0 1.1 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Neurochondrin PF05536.9 MSTRG.4532.1_3 - 0.00024 19.5 0.1 0.073 11.3 0.0 2.1 1 1 1 2 2 2 2 Neurochondrin V-ATPase_H_N PF03224.12 MSTRG.4532.1_3 - 0.0014 17.9 0.6 0.027 13.6 0.6 2.0 1 1 0 1 1 1 1 V-ATPase subunit H Nop16 PF09420.8 MSTRG.56.2_3 - 1.2e-18 67.8 14.7 2.8e-12 47.0 1.6 2.2 1 1 1 2 2 2 2 Ribosome biogenesis protein Nop16 Ribosomal_S17_N PF16205.3 MSTRG.14253.3_1 - 4.6e-13 49.2 0.0 8.4e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.18 MSTRG.14253.3_2 - 1.6e-09 37.6 0.2 2.9e-09 36.8 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 Ribosomal_S17_N PF16205.3 MSTRG.14253.3_3 - 5.4e-14 52.2 0.4 8.6e-14 51.5 0.4 1.3 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.18 MSTRG.14253.3_3 - 9.5e-14 51.2 0.2 1.8e-13 50.3 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 Pkinase_Tyr PF07714.15 MSTRG.18061.1_1 - 4.4e-33 114.5 0.0 5.7e-33 114.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.18061.1_1 - 1.8e-30 106.0 0.0 2.2e-30 105.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain PLC-beta_C PF08703.8 MSTRG.24718.1_3 - 2.2e-60 203.5 37.1 2.2e-60 203.5 37.1 2.6 3 0 0 3 3 3 1 PLC-beta C terminal PI-PLC-Y PF00387.17 MSTRG.24718.1_3 - 1.2e-40 138.3 0.6 1.2e-40 138.3 0.6 2.7 4 0 0 4 4 4 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.28 MSTRG.24718.1_3 - 1.6e-07 31.4 0.1 5.6e-07 29.7 0.0 1.9 2 0 0 2 2 2 1 C2 domain DUF1154 PF06631.9 MSTRG.24718.1_3 - 1.5e-05 24.8 5.8 1.5e-05 24.8 5.8 3.7 4 0 0 4 4 4 1 Protein of unknown function (DUF1154) PI-PLC-X PF00388.17 MSTRG.24718.1_3 - 0.0028 17.1 0.0 0.0076 15.7 0.0 1.8 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PhdYeFM_antitox PF02604.17 MSTRG.2181.1_3 - 0.055 13.1 1.1 1.2 8.9 0.1 2.4 1 1 1 2 2 2 0 Antitoxin Phd_YefM, type II toxin-antitoxin system KorB_C PF06613.9 MSTRG.2181.1_3 - 0.078 12.8 0.9 0.3 10.9 0.2 2.0 1 1 1 2 2 2 0 KorB C-terminal beta-barrel domain Exo_endo_phos PF03372.21 MSTRG.2181.1_3 - 0.18 12.0 0.0 0.19 11.9 0.0 1.1 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family SRCR PF00530.16 MSTRG.19108.1_3 - 1.6e-63 211.3 21.1 3.2e-32 110.9 4.0 3.3 3 0 0 3 3 3 2 Scavenger receptor cysteine-rich domain Zona_pellucida PF00100.21 MSTRG.19108.1_3 - 3.6e-40 138.2 0.0 7.1e-40 137.2 0.0 1.5 1 0 0 1 1 1 1 Zona pellucida-like domain SRCR_2 PF15494.4 MSTRG.19108.1_3 - 5.9e-08 33.0 7.4 0.00025 21.4 0.3 3.3 3 0 0 3 3 3 2 Scavenger receptor cysteine-rich domain EGF_3 PF12947.5 MSTRG.19108.1_3 - 7.5e-06 25.9 3.6 7.5e-06 25.9 3.6 3.5 3 0 0 3 3 3 2 EGF domain EGF_CA PF07645.13 MSTRG.19108.1_3 - 2.2e-05 24.4 0.1 2.2e-05 24.4 0.1 5.8 4 2 2 6 6 6 1 Calcium-binding EGF domain TYW3 PF02676.12 MSTRG.19108.1_3 - 0.067 12.4 0.9 0.81 8.8 0.1 2.1 2 0 0 2 2 2 0 Methyltransferase TYW3 Hormone_recep PF00104.28 MSTRG.9556.1_1 - 5.5e-30 104.4 5.5 1.1e-29 103.4 5.5 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 MSTRG.9556.1_1 - 4.7e-24 84.5 13.1 4.7e-24 84.5 13.1 2.7 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) GCR PF02155.13 MSTRG.9556.1_1 - 2e-12 46.7 3.6 1.5e-11 43.9 3.6 1.9 1 1 0 1 1 1 1 Glucocorticoid receptor BRCA2 PF00634.16 MSTRG.26830.1_3 - 0.069 12.5 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 BRCA2 repeat RFX_DNA_binding PF02257.13 MSTRG.18955.1_2 - 4.1e-32 110.5 0.1 1.1e-31 109.1 0.1 1.7 1 0 0 1 1 1 1 RFX DNA-binding domain RFX1_trans_act PF04589.11 MSTRG.18955.1_2 - 1.1e-31 110.0 21.0 1.1e-31 110.0 21.0 2.6 2 1 1 3 3 3 1 RFX1 transcription activation region GATA PF00320.25 MSTRG.96.1_1 - 8.9e-06 25.1 3.8 1.8e-05 24.1 3.8 1.5 1 0 0 1 1 1 1 GATA zinc finger FANCI_S1-cap PF14674.4 MSTRG.10690.5_2 - 0.36 10.8 1.9 3.7e+02 1.2 0.0 4.6 6 0 0 6 6 6 0 FANCI solenoid 1 cap zf-C2H2 PF00096.24 MSTRG.21018.1_3 - 8.3e-23 79.4 54.0 7.1e-05 22.9 1.0 6.8 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.21018.1_3 - 6e-18 64.3 47.8 3.8e-05 23.8 1.0 7.1 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.21018.1_3 - 2.2e-12 46.5 48.3 0.0012 19.4 0.7 7.0 6 0 0 6 6 6 6 C2H2-type zinc finger zf-met PF12874.5 MSTRG.21018.1_3 - 0.041 14.2 1.2 0.041 14.2 1.2 6.5 6 0 0 6 6 6 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 MSTRG.21018.1_3 - 3.4 7.6 43.7 0.025 14.4 3.8 6.5 6 0 0 6 6 6 0 C2H2-type zinc finger zf-C2H2_11 PF16622.3 MSTRG.21018.1_3 - 7.2 6.3 32.5 1.3 8.7 0.0 5.6 6 0 0 6 6 6 0 zinc-finger C2H2-type PWWP PF00855.15 MSTRG.1905.1_2 - 4.7e-05 23.6 0.1 0.00013 22.2 0.1 1.8 1 0 0 1 1 1 1 PWWP domain RAI1 PF08652.9 MSTRG.706.4_2 - 8.1e-22 77.1 0.0 1.7e-21 76.0 0.0 1.6 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease PhoLip_ATPase_C PF16212.3 MSTRG.7378.1_1 - 2.7e-76 256.5 28.6 2.7e-76 256.5 28.6 2.0 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.3 MSTRG.7378.1_1 - 8.3e-19 67.0 0.2 8.3e-19 67.0 0.2 2.5 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.24 MSTRG.7378.1_1 - 2.7e-10 40.7 0.0 0.00057 20.1 0.0 3.2 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.4 MSTRG.7378.1_1 - 2.1e-07 30.8 0.0 6.8e-07 29.2 0.0 1.8 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.18 MSTRG.7378.1_1 - 5.8e-07 28.9 0.0 1.9e-06 27.2 0.0 1.9 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.10 MSTRG.7378.1_1 - 0.0043 16.7 0.2 0.026 14.1 0.2 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Astacin PF01400.22 MSTRG.13284.2_1 - 6.6e-56 188.8 0.0 9.2e-56 188.4 0.0 1.2 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.22 MSTRG.13284.2_1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Matrixin SWIM PF04434.15 MSTRG.12220.1_1 - 0.098 12.2 4.0 0.25 10.9 4.0 1.7 1 0 0 1 1 1 0 SWIM zinc finger Patched PF02460.16 MSTRG.8400.1_2 - 1e-40 139.5 1.5 1.5e-25 89.3 0.0 2.2 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.6 MSTRG.8400.1_2 - 8.1e-30 103.6 0.7 8.1e-30 103.6 0.7 2.7 2 1 1 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.13 MSTRG.8400.1_2 - 6.1 5.5 8.9 0.23 10.2 0.8 2.2 2 0 0 2 2 2 0 MMPL family Autophagy_C PF10381.7 MSTRG.3156.1_3 - 0.14 11.6 0.6 0.27 10.6 0.6 1.5 1 0 0 1 1 1 0 Autophagocytosis associated protein C-terminal Troponin PF00992.18 MSTRG.5885.1_3 - 9.7e-31 106.7 47.8 2.5e-26 92.4 31.5 2.6 2 1 1 3 3 3 2 Troponin TonB_N PF16031.3 MSTRG.5885.1_3 - 0.0018 18.7 22.3 0.0018 18.7 22.3 2.5 3 0 0 3 3 3 1 TonB N-terminal region Trypan_PARP PF05887.9 MSTRG.5885.1_3 - 4 7.3 44.3 0.17 11.8 36.0 2.4 2 1 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Transferrin PF00405.15 MSTRG.4204.2_2 - 3.8e-195 647.4 7.9 3.2e-105 351.8 0.2 2.1 2 0 0 2 2 2 2 Transferrin Phosphonate-bd PF12974.5 MSTRG.4204.2_2 - 3.7e-14 52.8 0.0 2.6e-06 27.1 0.0 2.6 2 2 0 2 2 2 2 ABC transporter, phosphonate, periplasmic substrate-binding protein DUF3991 PF13154.4 MSTRG.4204.2_2 - 0.009 16.2 0.1 4.9 7.4 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF3991) DUF3915 PF13054.4 MSTRG.25651.1_1 - 2.9 7.8 18.3 0.061 13.2 9.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) EMI PF07546.11 MSTRG.25651.1_2 - 8.9e-16 58.3 13.6 8.9e-16 58.3 13.6 2.6 3 0 0 3 3 1 1 EMI domain C1q PF00386.19 MSTRG.25651.1_2 - 4.6e-11 42.9 0.0 1.5e-10 41.2 0.0 1.9 1 1 0 1 1 1 1 C1q domain Collagen PF01391.16 MSTRG.25651.1_2 - 2e-10 40.2 23.7 4.7e-10 39.0 23.7 1.6 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) Reo_sigmaC PF04582.10 MSTRG.25651.1_2 - 1.1e-07 31.4 17.5 0.066 12.5 0.3 4.8 3 1 2 5 5 5 3 Reovirus sigma C capsid protein Baculo_PEP_C PF04513.10 MSTRG.25651.1_2 - 6.9e-07 29.3 18.8 1.1 9.2 0.0 7.1 4 2 2 7 7 7 2 Baculovirus polyhedron envelope protein, PEP, C terminus Apolipoprotein PF01442.16 MSTRG.25651.1_2 - 2.6e-06 27.4 12.2 0.0014 18.5 0.0 4.1 3 2 0 3 3 3 2 Apolipoprotein A1/A4/E domain DNA_Packaging_2 PF11123.6 MSTRG.25651.1_2 - 0.00017 21.7 0.1 0.0022 18.1 0.0 2.7 1 1 1 2 2 2 1 DNA packaging protein EzrA PF06160.10 MSTRG.25651.1_2 - 0.00029 19.1 5.8 0.17 9.9 0.1 4.2 3 1 0 3 3 3 2 Septation ring formation regulator, EzrA Filament PF00038.19 MSTRG.25651.1_2 - 0.0011 18.5 0.1 0.0011 18.5 0.1 4.5 3 2 1 4 4 4 1 Intermediate filament protein Spectrin PF00435.19 MSTRG.25651.1_2 - 0.002 18.4 5.8 0.025 14.9 0.2 4.3 4 1 1 5 5 3 1 Spectrin repeat DUF16 PF01519.14 MSTRG.25651.1_2 - 0.0024 18.2 23.3 4.9 7.6 0.4 7.3 5 1 2 7 7 7 0 Protein of unknown function DUF16 DUF1664 PF07889.10 MSTRG.25651.1_2 - 0.006 16.4 26.9 0.25 11.2 0.0 7.8 4 3 3 8 8 8 2 Protein of unknown function (DUF1664) Laminin_II PF06009.10 MSTRG.25651.1_2 - 0.025 14.5 17.7 0.081 12.8 1.0 5.2 4 2 1 6 6 5 0 Laminin Domain II Snapin_Pallidin PF14712.4 MSTRG.25651.1_2 - 0.028 14.7 12.3 62 4.0 0.4 7.0 6 3 0 6 6 6 0 Snapin/Pallidin Spc7 PF08317.9 MSTRG.25651.1_2 - 0.033 12.9 0.1 0.033 12.9 0.1 4.6 3 1 2 5 5 5 0 Spc7 kinetochore protein IncA PF04156.12 MSTRG.25651.1_2 - 0.081 12.6 20.4 11 5.6 0.6 6.3 3 1 1 5 5 5 0 IncA protein IFT57 PF10498.7 MSTRG.25651.1_2 - 0.084 11.7 12.8 0.52 9.1 0.6 4.6 5 1 0 6 6 6 0 Intra-flagellar transport protein 57 FUSC PF04632.10 MSTRG.25651.1_2 - 0.088 11.2 0.4 0.86 7.9 0.0 2.5 2 1 1 3 3 3 0 Fusaric acid resistance protein family Dynamin_M PF01031.18 MSTRG.25651.1_2 - 0.14 11.2 3.4 0.8 8.7 0.3 2.9 3 0 0 3 3 3 0 Dynamin central region Paralemmin PF03285.13 MSTRG.25651.1_2 - 0.15 11.5 10.0 2 7.8 0.1 2.9 2 1 0 2 2 2 0 Paralemmin Dynamitin PF04912.12 MSTRG.25651.1_2 - 0.31 10.2 7.7 1.3 8.2 0.3 3.5 2 1 1 3 3 3 0 Dynamitin YtxH PF12732.5 MSTRG.25651.1_2 - 0.32 11.4 6.2 1.2 9.6 0.4 4.0 5 0 0 5 5 2 0 YtxH-like protein TRAF_BIRC3_bd PF16673.3 MSTRG.25651.1_2 - 0.36 10.5 9.5 0.037 13.7 0.9 3.8 4 0 0 4 4 3 0 TNF receptor-associated factor BIRC3 binding domain RPW8 PF05659.9 MSTRG.25651.1_2 - 0.4 10.2 5.4 2 7.9 0.1 4.3 5 1 0 5 5 4 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Laminin_I PF06008.12 MSTRG.25651.1_2 - 0.54 9.8 10.6 2.7 7.5 0.0 3.3 3 0 0 3 3 3 0 Laminin Domain I BST2 PF16716.3 MSTRG.25651.1_2 - 0.71 10.3 20.4 11 6.5 2.5 7.0 7 1 0 7 7 7 0 Bone marrow stromal antigen 2 KLRAQ PF10205.7 MSTRG.25651.1_2 - 1.1 9.4 0.0 1.1 9.4 0.0 4.3 5 1 0 5 5 4 0 Predicted coiled-coil domain-containing protein FlaC_arch PF05377.9 MSTRG.25651.1_2 - 1.3 9.4 21.1 9.7 6.5 0.2 8.1 7 2 2 9 9 8 0 Flagella accessory protein C (FlaC) DUF948 PF06103.9 MSTRG.25651.1_2 - 1.3 9.2 22.3 9.6 6.4 0.2 7.0 6 2 2 8 8 7 0 Bacterial protein of unknown function (DUF948) Sec34 PF04136.13 MSTRG.25651.1_2 - 1.5 8.6 8.4 5 6.9 0.5 4.2 4 0 0 4 4 4 0 Sec34-like family CENP-F_leu_zip PF10473.7 MSTRG.25651.1_2 - 1.6 8.6 20.5 5 7.0 6.4 5.6 3 2 2 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1043 PF06295.10 MSTRG.25651.1_2 - 1.8 8.5 3.7 16 5.4 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1043) TMF_DNA_bd PF12329.6 MSTRG.25651.1_2 - 2.5 8.0 15.5 18 5.3 0.1 6.3 8 0 0 8 8 7 0 TATA element modulatory factor 1 DNA binding Fib_alpha PF08702.8 MSTRG.25651.1_2 - 3.2 7.8 31.8 2.5 8.1 1.7 6.6 2 2 7 9 9 9 0 Fibrinogen alpha/beta chain family NPV_P10 PF05531.10 MSTRG.25651.1_2 - 5 7.5 19.3 7.8 6.9 0.3 7.2 5 3 3 8 8 7 0 Nucleopolyhedrovirus P10 protein DASH_Duo1 PF08651.8 MSTRG.25651.1_2 - 5.7 6.6 8.0 32 4.3 0.2 5.1 6 1 1 7 7 5 0 DASH complex subunit Duo1 APG6 PF04111.10 MSTRG.25651.1_2 - 6.8 5.9 14.3 16 4.7 0.1 4.3 3 2 0 4 4 4 0 Autophagy protein Apg6 DUF4539 PF15072.4 MSTRG.2484.1_3 - 2.9e-31 107.2 0.0 5e-31 106.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4539) PX PF00787.22 MSTRG.19542.1_1 - 1.8e-11 43.9 0.4 4e-11 42.8 0.4 1.6 1 0 0 1 1 1 1 PX domain Vps5 PF09325.8 MSTRG.19542.1_1 - 3.5e-05 23.3 2.5 3.5e-05 23.3 2.5 1.8 2 1 0 2 2 2 1 Vps5 C terminal like DUF3373 PF11853.6 MSTRG.19542.1_1 - 0.024 13.3 0.2 0.031 12.9 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Phage_GP20 PF06810.9 MSTRG.19542.1_1 - 0.048 13.3 0.9 0.087 12.5 0.9 1.3 1 0 0 1 1 1 0 Phage minor structural protein GP20 GCN5L1 PF06320.11 MSTRG.19542.1_1 - 0.059 13.4 0.5 0.34 10.9 0.5 2.1 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) DUF1690 PF07956.9 MSTRG.19542.1_1 - 0.38 11.1 4.3 0.76 10.1 4.3 1.4 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) PX PF00787.22 MSTRG.19542.1_2 - 2.6e-20 72.4 0.2 7e-20 71.0 0.2 1.7 1 0 0 1 1 1 1 PX domain Plectin PF00681.18 MSTRG.7674.2_1 - 2.4e-60 200.0 0.0 2.7e-13 49.4 0.0 11.5 11 2 1 12 12 12 8 Plectin repeat Spectrin PF00435.19 MSTRG.7674.2_1 - 1e-06 29.0 17.2 1e-05 25.8 5.3 17.9 11 6 4 17 17 17 5 Spectrin repeat ERM PF00769.17 MSTRG.7674.2_1 - 0.0013 18.5 33.5 0.0013 18.5 33.5 11.4 4 2 5 10 10 10 1 Ezrin/radixin/moesin family Imm59 PF15597.4 MSTRG.7674.2_1 - 0.066 13.4 2.9 0.51 10.5 2.9 2.6 1 0 0 1 1 1 0 Immunity protein 59 Kinesin PF00225.21 MSTRG.21578.4_3 - 3.9e-99 331.6 0.0 5.3e-99 331.2 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 MSTRG.21578.4_3 - 2.2e-44 150.9 0.0 3.6e-44 150.2 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding DUF972 PF06156.11 MSTRG.21578.4_3 - 0.0059 17.1 6.0 2.4 8.7 0.0 4.8 4 1 1 5 5 5 1 Protein of unknown function (DUF972) TSC22 PF01166.16 MSTRG.21578.4_3 - 0.023 14.9 0.4 12 6.1 0.1 3.4 3 0 0 3 3 3 0 TSC-22/dip/bun family Spc7 PF08317.9 MSTRG.21578.4_3 - 0.1 11.3 6.1 1.8 7.3 0.2 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein End3 PF12761.5 MSTRG.21578.4_3 - 0.18 11.9 4.3 0.36 10.8 4.3 1.5 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 DUF87 PF01935.15 MSTRG.21578.4_3 - 0.34 10.8 2.0 2.4 8.0 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF87 APG6 PF04111.10 MSTRG.21578.4_3 - 0.43 9.8 4.8 0.74 9.0 4.8 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 Exonuc_VII_L PF02601.13 MSTRG.21578.4_3 - 0.54 9.6 6.7 1 8.7 6.7 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1664 PF07889.10 MSTRG.21578.4_3 - 0.55 10.1 2.3 3.5 7.5 0.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Filament PF00038.19 MSTRG.21578.4_3 - 0.78 9.1 13.5 5 6.5 0.8 2.6 1 1 0 2 2 2 0 Intermediate filament protein DUF4407 PF14362.4 MSTRG.21578.4_3 - 1.1 8.4 6.6 4.7 6.3 6.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) HIP1_clath_bdg PF16515.3 MSTRG.21578.4_3 - 1.9 9.0 10.0 0.73 10.3 0.4 3.1 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Atg14 PF10186.7 MSTRG.21578.4_3 - 2 7.3 6.9 2.4 7.0 5.3 1.8 1 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fez1 PF06818.13 MSTRG.21578.4_3 - 2.7 8.3 9.9 13 6.1 9.9 2.0 1 1 0 1 1 1 0 Fez1 ADIP PF11559.6 MSTRG.21578.4_3 - 2.8 7.9 13.7 2.4 8.1 0.4 3.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding SlyX PF04102.10 MSTRG.21578.4_3 - 7.2 7.2 12.0 1.7 9.2 5.6 3.5 3 1 1 4 4 4 0 SlyX YlqD PF11068.6 MSTRG.21578.4_3 - 9.9 6.4 9.7 48 4.2 5.2 2.6 1 1 0 2 2 2 0 YlqD protein Ion_trans PF00520.29 MSTRG.4416.1_2 - 1.6e-50 171.5 15.4 1.6e-50 171.5 15.4 1.9 2 0 0 2 2 2 1 Ion transport protein HemY_N PF07219.11 MSTRG.4416.1_2 - 0.25 11.4 0.0 0.25 11.4 0.0 2.2 3 0 0 3 3 3 0 HemY protein N-terminus EphA2_TM PF14575.4 MSTRG.4416.1_2 - 0.27 12.0 0.9 1.1 9.9 0.2 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain tRNA-synt_2d PF01409.18 MSTRG.19539.1_3 - 1.6e-47 161.9 0.6 5.1e-30 104.6 0.1 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.12 MSTRG.19539.1_3 - 2e-24 85.7 0.0 1.8e-22 79.4 0.0 2.5 2 0 0 2 2 2 1 Ferredoxin-fold anticodon binding domain tRNA-synt_2 PF00152.18 MSTRG.19539.1_3 - 0.024 13.6 0.0 3.9 6.3 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class II (D, K and N) Peptidase_C48 PF02902.17 MSTRG.17602.1_1 - 1.8e-10 40.9 0.0 5.3e-10 39.4 0.0 1.9 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain TNFR_c6 PF00020.16 MSTRG.1699.5_2 - 2.2e-12 47.1 36.3 9.3e-09 35.4 2.8 3.9 4 0 0 4 4 4 3 TNFR/NGFR cysteine-rich region PI3_PI4_kinase PF00454.25 MSTRG.25129.1_2 - 3.5e-48 164.5 1.2 5.6e-47 160.5 1.2 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.18 MSTRG.25129.1_2 - 3.5e-28 98.1 0.8 7.3e-28 97.1 0.8 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) C2 PF00168.28 MSTRG.25129.1_2 - 7.3e-11 42.1 0.1 2.4e-09 37.3 0.2 2.6 2 0 0 2 2 2 1 C2 domain PI3K_C2 PF00792.22 MSTRG.25129.1_2 - 9.9e-09 35.2 0.1 2.6e-08 33.9 0.1 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.16 MSTRG.25129.1_2 - 5.3e-08 32.9 0.2 1.2e-07 31.7 0.2 1.7 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain PX PF00787.22 MSTRG.25129.1_2 - 0.00016 21.5 0.1 0.00082 19.2 0.1 2.3 1 0 0 1 1 1 1 PX domain DUF4135 PF13575.4 MSTRG.25129.1_2 - 0.004 16.4 0.0 0.0067 15.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) SAM_2 PF07647.15 MSTRG.7997.1_3 - 1e-08 35.0 0.0 2.6e-08 33.7 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 MSTRG.7997.1_3 - 1.5e-08 34.9 0.0 3.4e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Arf PF00025.19 MSTRG.3993.2_2 - 3.4e-61 205.6 0.0 4.6e-61 205.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 MSTRG.3993.2_2 - 1.1e-06 28.0 0.0 1.6e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.11 MSTRG.3993.2_2 - 1.4e-06 28.4 0.0 2.6e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 MSTRG.3993.2_2 - 1.5e-05 24.5 0.0 2.1e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Ras family G-alpha PF00503.18 MSTRG.3993.2_2 - 2.9e-05 23.3 0.1 0.0025 16.9 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.21 MSTRG.3993.2_2 - 0.00012 22.1 0.0 0.00017 21.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 MSTRG.3993.2_2 - 0.12 11.6 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region UCH PF00443.27 MSTRG.7169.1_3 - 6e-70 235.5 0.6 7.3e-70 235.3 0.6 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 MSTRG.7169.1_3 - 8.3e-27 94.5 1.5 1.1e-26 94.1 1.5 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.4 MSTRG.7169.1_3 - 0.69 9.2 11.1 1.3e+02 1.7 11.1 3.5 1 1 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Ribosomal_L39 PF00832.18 MSTRG.8069.2_1 - 0.58 9.7 6.7 0.48 10.0 0.9 2.6 2 0 0 2 2 2 0 Ribosomal L39 protein Homeobox PF00046.27 MSTRG.8069.2_3 - 1.3e-21 76.0 1.7 2.3e-21 75.2 1.7 1.4 1 0 0 1 1 1 1 Homeobox domain YdaS_antitoxin PF15943.3 MSTRG.8069.2_3 - 0.068 12.9 0.3 2.8 7.7 0.0 2.3 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT EF-hand_1 PF00036.30 MSTRG.3538.1_1 - 7.4e-16 56.3 0.2 3.5e-05 22.9 0.0 4.6 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.4 MSTRG.3538.1_1 - 1.9e-12 46.6 2.0 1.1e-08 34.5 0.1 3.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.3538.1_1 - 8.1e-12 43.9 0.9 3.8e-05 23.2 0.0 4.3 5 0 0 5 5 5 3 EF-hand domain EF-hand_7 PF13499.4 MSTRG.3538.1_1 - 2.7e-10 40.4 0.1 8.4e-05 22.8 0.0 2.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.3538.1_1 - 9.1e-07 28.0 1.0 0.05 13.0 0.0 3.4 3 0 0 3 3 3 2 EF hand DcpS_C PF11969.6 MSTRG.23083.2_2 - 6.3e-32 110.3 0.5 1e-31 109.6 0.5 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.21 MSTRG.23083.2_2 - 1.4e-08 35.2 1.1 3.4e-08 34.0 1.1 1.7 1 1 0 1 1 1 1 HIT domain NAGPA PF09992.7 MSTRG.12651.1_2 - 4.4e-38 131.0 0.1 5.8e-38 130.6 0.1 1.2 1 0 0 1 1 1 1 Phosphodiester glycosidase EGF_2 PF07974.11 MSTRG.12651.1_2 - 0.0022 18.2 15.3 0.0022 18.2 15.3 5.5 6 0 0 6 6 6 3 EGF-like domain PH PF00169.27 MSTRG.18734.1_1 - 0.00036 20.9 0.2 0.00083 19.7 0.2 1.6 1 1 0 1 1 1 1 PH domain DUF3498 PF12004.6 MSTRG.9230.1_3 - 4.4e-10 39.2 0.7 5.6e-10 38.9 0.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3498) Pribosyl_synth PF14572.4 MSTRG.21724.1_2 - 3.4e-99 330.3 1.0 5e-99 329.7 1.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.4 MSTRG.21724.1_2 - 1.1e-38 131.6 0.3 2.1e-38 130.7 0.3 1.5 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.25 MSTRG.21724.1_2 - 3.6e-06 26.4 0.3 3.5e-05 23.2 0.1 2.1 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UQ_con PF00179.24 MSTRG.5478.1_3 - 6.8e-09 35.4 0.0 7.5e-08 32.0 0.0 2.5 2 1 0 2 2 2 1 Ubiquitin-conjugating enzyme RWD PF05773.20 MSTRG.5478.1_3 - 0.0019 18.3 0.1 0.032 14.4 0.1 2.3 2 0 0 2 2 2 1 RWD domain Prok-E2_B PF14461.4 MSTRG.5478.1_3 - 0.022 14.3 0.0 0.05 13.2 0.0 1.5 1 0 0 1 1 1 0 Prokaryotic E2 family B RMI1_C PF16099.3 MSTRG.5749.2_3 - 2.7e-37 127.7 0.0 3.9e-37 127.1 0.0 1.3 1 0 0 1 1 1 1 Recq-mediated genome instability protein 1, C-terminal OB-fold RMI1_N PF08585.10 MSTRG.5749.2_3 - 1.5e-07 31.3 0.7 2.9e-07 30.3 0.7 1.5 1 0 0 1 1 1 1 RecQ mediated genome instability protein PHD PF00628.27 MSTRG.17923.4_2 - 8.6e-37 124.7 105.9 2.3e-09 36.8 7.3 8.2 6 2 2 8 8 8 6 PHD-finger HMG_box PF00505.17 MSTRG.17923.4_2 - 0.0007 19.8 0.1 0.0007 19.8 0.1 2.3 3 0 0 3 3 3 1 HMG (high mobility group) box zf-HC5HC2H_2 PF13832.4 MSTRG.17923.4_2 - 0.0037 17.3 1.6 0.0037 17.3 1.6 7.4 3 3 4 7 7 7 2 PHD-zinc-finger like domain HMG_box_2 PF09011.8 MSTRG.17923.4_2 - 0.015 15.7 0.5 0.068 13.6 0.5 2.1 1 0 0 1 1 1 0 HMG-box domain DREPP PF05558.10 MSTRG.17923.4_2 - 8.2 6.1 8.9 32 4.2 8.9 2.0 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide MGAT2 PF05060.12 MSTRG.23373.1_3 - 8.7e-150 498.4 0.5 1.1e-149 498.1 0.5 1.1 1 0 0 1 1 1 1 N-acetylglucosaminyltransferase II (MGAT2) CAP_N PF01213.17 MSTRG.13869.1_3 - 0.1 11.9 0.4 0.18 11.1 0.4 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Sporozoite_P67 PF05642.9 MSTRG.13869.1_3 - 0.84 7.5 1.9 1.1 7.1 1.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen 3Beta_HSD PF01073.17 MSTRG.2521.1_2 - 5.1e-90 301.1 0.0 6.5e-90 300.8 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 MSTRG.2521.1_2 - 4.3e-23 81.9 0.0 5.8e-23 81.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.10 MSTRG.2521.1_2 - 3.1e-13 49.4 0.5 1e-12 47.7 0.5 1.6 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.3 MSTRG.2521.1_2 - 6.5e-13 48.6 0.0 8.6e-13 48.2 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.13 MSTRG.2521.1_2 - 1.6e-09 37.2 0.1 3.8e-09 36.0 0.1 1.5 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.4 MSTRG.2521.1_2 - 3e-09 36.9 0.0 4.1e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.15 MSTRG.2521.1_2 - 1.3e-08 34.2 0.0 2.1e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.8 MSTRG.2521.1_2 - 3.5e-06 26.9 0.2 9.3e-06 25.5 0.2 1.6 1 1 0 1 1 1 1 KR domain NmrA PF05368.11 MSTRG.2521.1_2 - 3.9e-05 23.2 0.1 5.6e-05 22.7 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family Sacchrp_dh_NADP PF03435.16 MSTRG.2521.1_2 - 0.00046 20.3 0.6 0.01 15.9 0.6 2.2 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain adh_short PF00106.23 MSTRG.2521.1_2 - 0.0059 16.0 0.2 0.011 15.1 0.2 1.4 1 1 0 1 1 1 1 short chain dehydrogenase DUF2516 PF10724.7 MSTRG.3409.1_2 - 0.21 11.8 0.1 0.21 11.8 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2516) Ras PF00071.20 MSTRG.5015.1_1 - 4e-59 198.7 0.0 1.6e-58 196.8 0.1 1.8 2 0 0 2 2 2 1 Ras family Roc PF08477.11 MSTRG.5015.1_1 - 2.1e-30 105.3 0.0 4e-30 104.4 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.5015.1_1 - 6.6e-11 41.8 0.0 1.1e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 MSTRG.5015.1_1 - 0.0012 18.7 0.0 0.0025 17.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 MSTRG.5015.1_1 - 0.017 14.5 0.0 0.12 11.8 0.0 2.0 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 MSTRG.5015.1_1 - 0.082 12.1 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF258 PF03193.14 MSTRG.5015.1_1 - 0.18 11.6 0.0 12 5.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF258 zf-C3HC4_4 PF15227.4 MSTRG.15597.1_2 - 2.5e-11 43.4 8.6 2.5e-11 43.4 8.6 3.4 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 MSTRG.15597.1_2 - 1.4e-10 40.7 4.9 1.4e-10 40.7 4.9 3.6 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.15597.1_2 - 4.4e-10 39.3 2.2 4.4e-10 39.3 2.2 3.7 3 1 1 4 4 4 1 RING-type zinc-finger zf-B_box PF00643.22 MSTRG.15597.1_2 - 6.4e-10 38.9 5.5 6.4e-10 38.9 5.5 4.8 6 0 0 6 6 6 1 B-box zinc finger zf-C3HC4_2 PF13923.4 MSTRG.15597.1_2 - 2.3e-09 36.8 6.3 2.3e-09 36.8 6.3 3.5 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 MSTRG.15597.1_2 - 3.7e-08 33.0 3.8 3.7e-08 33.0 3.8 3.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.15597.1_2 - 4.2e-06 26.8 7.0 4.2e-06 26.8 7.0 4.4 3 1 1 4 4 4 1 Ring finger domain zf-RING_5 PF14634.4 MSTRG.15597.1_2 - 2.3e-05 24.1 5.0 2.3e-05 24.1 5.0 3.9 4 0 0 4 4 4 1 zinc-RING finger domain zf-RING_6 PF14835.4 MSTRG.15597.1_2 - 0.00015 21.4 3.0 0.00015 21.4 3.0 2.2 2 0 0 2 2 2 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.4 MSTRG.15597.1_2 - 0.00054 19.6 4.8 0.00054 19.6 4.8 3.5 4 0 0 4 4 4 1 Prokaryotic RING finger family 4 Na_Ca_ex PF01699.22 MSTRG.24545.1_3 - 3.2e-57 192.6 49.6 2.6e-29 102.0 22.6 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein A_deaminase PF00962.20 MSTRG.4456.2_1 - 2.9e-35 122.0 0.0 4e-35 121.6 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase A_deaminase PF00962.20 MSTRG.4456.2_3 - 1.6e-17 63.7 0.1 2.2e-17 63.3 0.1 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase ALAD PF00490.19 MSTRG.18714.1_2 - 5.4e-36 124.2 0.0 6.6e-36 123.9 0.0 1.1 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase DUF3502 PF12010.6 MSTRG.18714.1_2 - 0.19 12.2 0.0 0.29 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3502) His_Phos_1 PF00300.20 MSTRG.22587.1_2 - 6.9e-34 117.1 0.0 4.4e-26 91.6 0.0 2.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Exc PF07825.9 MSTRG.22587.1_2 - 0.059 13.2 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 Excisionase-like protein zf-H2C2_5 PF13909.4 MSTRG.21126.2_3 - 0.51 10.0 14.1 0.31 10.7 1.0 3.7 4 0 0 4 4 4 0 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.4 MSTRG.21126.2_3 - 0.87 10.0 33.3 1.1 9.6 0.1 6.6 6 0 0 6 6 6 0 Zinc-finger double domain Ldl_recept_a PF00057.16 MSTRG.25618.1_1 - 1.9e-278 898.2 615.6 3.5e-10 39.8 8.2 38.2 35 3 3 38 38 38 37 Low-density lipoprotein receptor domain class A FXa_inhibition PF14670.4 MSTRG.25618.1_1 - 3.6e-18 65.4 52.8 6.2e-10 39.1 5.9 19.7 21 0 0 21 21 21 6 Coagulation Factor Xa inhibitory site Ldl_recept_b PF00058.15 MSTRG.25618.1_1 - 1.1e-15 57.7 4.4 0.0053 17.1 0.0 8.1 7 0 0 7 7 7 4 Low-density lipoprotein receptor repeat class B EGF_CA PF07645.13 MSTRG.25618.1_1 - 2.3e-10 40.4 24.2 3.1e-07 30.4 7.9 33.5 30 8 10 40 40 40 2 Calcium-binding EGF domain cEGF PF12662.5 MSTRG.25618.1_1 - 9.7e-09 34.9 8.5 3.2e-06 26.8 0.7 14.2 13 0 0 13 13 13 4 Complement Clr-like EGF-like EGF PF00008.25 MSTRG.25618.1_1 - 0.0024 18.0 7.3 0.0024 18.0 7.3 23.9 26 1 0 26 26 26 7 EGF-like domain HECT PF00632.23 MSTRG.15124.1_3 - 3.9e-101 338.4 0.1 5.4e-101 338.0 0.1 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.24 MSTRG.15124.1_3 - 1.4e-50 168.7 27.1 1.8e-12 46.8 4.4 4.7 4 0 0 4 4 4 4 WW domain C2 PF00168.28 MSTRG.15124.1_3 - 2.3e-24 85.5 0.1 7e-24 84.0 0.0 1.9 2 0 0 2 2 2 1 C2 domain JmjC PF02373.20 MSTRG.11779.1_3 - 2.8e-11 43.7 0.3 2.5e-10 40.7 0.3 2.3 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.4 MSTRG.11779.1_3 - 1.6e-09 37.8 0.0 6.3e-09 35.9 0.0 1.8 1 1 0 1 1 1 1 Cupin-like domain PHD PF00628.27 MSTRG.11779.1_3 - 3.1e-08 33.2 6.8 6.2e-08 32.3 6.8 1.5 1 0 0 1 1 1 1 PHD-finger PHD_4 PF16866.3 MSTRG.11779.1_3 - 0.039 13.9 2.0 0.095 12.7 2.0 1.6 1 0 0 1 1 1 0 PHD-finger zf-RING_2 PF13639.4 MSTRG.11779.1_3 - 4.6 7.5 6.9 10 6.3 6.9 1.6 1 0 0 1 1 1 0 Ring finger domain PRKCSH_1 PF13015.4 MSTRG.21937.1_1 - 1.9e-07 30.8 0.0 3.1e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.11 MSTRG.21937.1_1 - 5.6e-07 30.3 1.0 1.4e-06 29.1 0.6 1.8 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein zf-MIZ PF02891.18 MSTRG.21937.1_2 - 6.1 6.6 11.0 0.59 9.8 0.6 3.1 2 1 1 3 3 3 0 MIZ/SP-RING zinc finger Ank_4 PF13637.4 MSTRG.25654.1_2 - 1e-22 80.0 0.0 1.9e-11 44.1 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 MSTRG.25654.1_2 - 7.2e-16 58.4 0.1 1.3e-14 54.4 0.0 2.2 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.25654.1_2 - 2.3e-15 56.3 0.9 3.6e-07 30.2 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.25654.1_2 - 1.4e-11 44.1 0.0 2.4e-07 30.8 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.4 MSTRG.25654.1_2 - 4.1e-11 42.0 0.0 2e-06 27.6 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeat Beta-TrCP_D PF12125.6 MSTRG.29039.1_3 - 0.04 13.7 0.4 0.06 13.1 0.4 1.2 1 0 0 1 1 1 0 D domain of beta-TrCP AAA_13 PF13166.4 MSTRG.11186.1_1 - 0.0026 16.4 2.1 0.0026 16.4 2.1 1.1 1 0 0 1 1 1 1 AAA domain Prefoldin_2 PF01920.18 MSTRG.11186.1_1 - 0.02 14.7 4.8 0.05 13.4 3.0 2.0 2 0 0 2 2 2 0 Prefoldin subunit DUF948 PF06103.9 MSTRG.11186.1_1 - 0.03 14.4 0.3 0.064 13.4 0.3 1.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) GrpE PF01025.17 MSTRG.11186.1_1 - 0.035 13.6 3.8 0.04 13.5 3.8 1.3 1 1 0 1 1 1 0 GrpE Prefoldin PF02996.15 MSTRG.11186.1_1 - 0.04 13.7 2.5 0.051 13.4 1.4 1.7 2 0 0 2 2 2 0 Prefoldin subunit DUF1664 PF07889.10 MSTRG.11186.1_1 - 0.056 13.3 1.3 0.94 9.3 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF3936 PF13072.4 MSTRG.11186.1_1 - 0.095 12.4 0.2 0.17 11.6 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3936) SlyX PF04102.10 MSTRG.11186.1_1 - 1.2 9.7 4.5 0.86 10.1 1.8 1.9 2 0 0 2 2 2 0 SlyX DNA_methylase PF00145.15 MSTRG.19967.1_2 - 3.2e-16 59.5 0.0 8.1e-12 45.0 0.0 2.2 2 0 0 2 2 2 2 C-5 cytosine-specific DNA methylase SURF2 PF05477.9 MSTRG.13139.2_1 - 8.5e-88 293.7 15.0 1e-87 293.4 15.0 1.0 1 0 0 1 1 1 1 Surfeit locus protein 2 (SURF2) LON_substr_bdg PF02190.14 MSTRG.16028.2_2 - 1.8e-19 70.3 0.0 3.2e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain zf-C3HC4_2 PF13923.4 MSTRG.16028.2_2 - 4.8e-16 58.2 27.4 2.8e-11 42.9 11.7 3.0 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 MSTRG.16028.2_2 - 9.7e-14 50.8 22.0 5.4e-09 35.7 7.3 2.7 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 MSTRG.16028.2_2 - 1e-13 51.1 26.1 1.9e-08 34.2 10.7 3.2 2 0 0 2 2 2 2 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 MSTRG.16028.2_2 - 4.7e-13 48.8 26.4 5.7e-08 32.5 13.4 3.0 2 0 0 2 2 2 2 RING-type zinc-finger zf-C3HC4 PF00097.23 MSTRG.16028.2_2 - 4e-12 45.7 27.8 8.2e-08 31.9 11.5 2.9 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 MSTRG.16028.2_2 - 1.7e-10 40.6 27.4 2.1e-06 27.5 10.7 2.9 2 0 0 2 2 2 2 zinc-RING finger domain zf-RING_2 PF13639.4 MSTRG.16028.2_2 - 1.9e-10 40.7 29.0 2.7e-07 30.6 11.9 3.0 2 0 0 2 2 2 2 Ring finger domain Prok-RING_4 PF14447.4 MSTRG.16028.2_2 - 7.2e-09 35.2 22.6 4.2e-06 26.4 9.0 2.7 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_10 PF16685.3 MSTRG.16028.2_2 - 1.7e-05 24.7 25.8 0.0013 18.7 8.0 2.6 2 0 0 2 2 2 2 zinc RING finger of MSL2 zf-RING_6 PF14835.4 MSTRG.16028.2_2 - 3.7e-05 23.4 12.5 0.0056 16.4 2.5 2.7 2 0 0 2 2 2 2 zf-RING of BARD1-type protein U-box PF04564.13 MSTRG.16028.2_2 - 0.00042 20.3 0.0 0.0047 17.0 0.0 2.3 2 0 0 2 2 2 1 U-box domain zf-Nse PF11789.6 MSTRG.16028.2_2 - 0.0017 18.0 20.7 0.0079 15.9 9.0 2.9 2 1 0 2 2 2 2 Zinc-finger of the MIZ type in Nse subunit TPR_9 PF13371.4 MSTRG.16028.2_2 - 0.0047 16.9 0.7 0.031 14.3 0.6 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat zf-rbx1 PF12678.5 MSTRG.16028.2_2 - 0.0072 16.5 9.8 0.0072 16.5 9.8 3.4 2 1 1 3 3 3 1 RING-H2 zinc finger domain TPR_14 PF13428.4 MSTRG.16028.2_2 - 0.081 13.7 0.1 0.25 12.1 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat zf-RING_4 PF14570.4 MSTRG.16028.2_2 - 0.1 12.2 19.7 0.36 10.5 8.8 3.3 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain DUF1272 PF06906.9 MSTRG.16028.2_2 - 0.48 10.4 20.7 0.79 9.7 6.2 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1272) SR-25 PF10500.7 MSTRG.23235.1_2 - 0.0014 18.2 29.1 0.0018 17.8 17.4 2.3 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein AP3D1 PF06375.9 MSTRG.23235.1_2 - 0.0096 16.1 16.5 0.0096 16.1 16.5 2.3 2 0 0 2 2 2 1 AP-3 complex subunit delta-1 Apt1 PF10351.7 MSTRG.23235.1_2 - 0.025 13.3 0.1 0.025 13.3 0.1 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain Dehydrin PF00257.17 MSTRG.23235.1_2 - 0.38 11.1 15.3 0.84 10.0 15.3 1.4 1 0 0 1 1 1 0 Dehydrin POX PF07526.9 MSTRG.23235.1_2 - 1 9.8 11.4 6.5 7.2 6.1 2.2 2 0 0 2 2 2 0 Associated with HOX Peptidase_S49_N PF08496.8 MSTRG.23235.1_2 - 3.6 7.5 21.5 1.3 8.9 11.1 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Eapp_C PF10238.7 MSTRG.23235.1_2 - 6.8 6.6 10.4 15 5.5 3.7 2.3 2 0 0 2 2 2 0 E2F-associated phosphoprotein 7tm_1 PF00001.19 MSTRG.25987.1_3 - 1.2e-41 142.6 11.2 1.9e-41 141.9 11.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 MSTRG.25987.1_3 - 1.1e-07 31.4 11.5 1.8e-07 30.7 11.5 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 MSTRG.25987.1_3 - 0.00018 21.2 17.6 0.0096 15.6 17.6 2.6 1 1 0 1 1 1 1 Olfactory receptor DUF3385 PF11865.6 MSTRG.3275.3_2 - 3.8e-63 212.0 4.2 1.3e-58 197.3 0.1 5.1 5 0 0 5 5 5 2 Domain of unknown function (DUF3385) HEAT_2 PF13646.4 MSTRG.3275.3_2 - 1.7e-14 53.8 0.9 0.0055 16.9 0.0 8.0 6 3 2 9 9 9 3 HEAT repeats FAT PF02259.21 MSTRG.3275.3_2 - 8.5e-14 51.4 0.3 8.5e-14 51.4 0.3 2.7 3 0 0 3 3 3 1 FAT domain HEAT PF02985.20 MSTRG.3275.3_2 - 3.2e-09 36.1 15.8 0.46 10.7 0.0 12.8 15 0 0 15 15 14 1 HEAT repeat HEAT_EZ PF13513.4 MSTRG.3275.3_2 - 1e-07 32.1 23.1 0.037 14.4 0.0 12.7 13 2 1 14 14 14 2 HEAT-like repeat Vac14_Fab1_bd PF12755.5 MSTRG.3275.3_2 - 1.3e-05 25.5 0.9 46 4.6 0.0 7.1 5 1 2 7 7 7 0 Vacuolar 14 Fab1-binding region Cnd1 PF12717.5 MSTRG.3275.3_2 - 2.6e-05 24.1 0.1 1.8 8.4 0.1 5.8 3 2 3 6 6 6 1 non-SMC mitotic condensation complex subunit 1 UME PF08064.11 MSTRG.3275.3_2 - 0.0031 17.3 7.9 3.1 7.6 0.3 5.7 7 0 0 7 7 7 2 UME (NUC010) domain EPSP_synthase PF00275.18 MSTRG.3275.3_2 - 0.0069 15.0 0.0 0.012 14.2 0.0 1.3 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) Sec7_N PF12783.5 MSTRG.3275.3_2 - 0.0096 15.8 0.7 23 4.8 0.0 4.8 5 0 0 5 5 5 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Tti2 PF10521.7 MSTRG.3275.3_2 - 0.5 9.7 6.2 0.8 9.0 0.1 4.0 4 2 0 4 4 4 0 Tti2 family DUF1394 PF07159.10 MSTRG.13314.4_3 - 1.3e-144 481.0 0.2 1.6e-144 480.7 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) V-ATPase_H_N PF03224.12 MSTRG.13314.4_3 - 0.015 14.5 0.0 0.021 14.0 0.0 1.2 1 0 0 1 1 1 0 V-ATPase subunit H Glyco_hydro_18 PF00704.26 MSTRG.22786.2_2 - 7.5e-35 121.0 0.0 9.1e-35 120.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Tox-REase-5 PF15648.4 MSTRG.22786.2_2 - 0.096 13.0 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 5 BBS2_Mid PF14783.4 MSTRG.25511.1_3 - 0.0012 18.7 0.0 16 5.5 0.0 4.3 4 1 1 5 5 5 1 Ciliary BBSome complex subunit 2, middle region VCBS PF13517.4 MSTRG.25511.1_3 - 0.11 13.0 0.0 0.89 10.1 0.0 2.4 2 1 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Cadherin_3 PF16184.3 MSTRG.24339.1_2 - 4.9e-20 71.5 0.0 6.2e-15 55.0 0.0 2.5 2 0 0 2 2 2 2 Cadherin-like Calx-beta PF03160.12 MSTRG.24339.1_2 - 8.5e-12 45.0 0.0 1.9e-11 43.9 0.0 1.6 2 0 0 2 2 2 1 Calx-beta domain MAP7 PF05672.9 MSTRG.15368.1_3 - 7.5e-47 158.9 78.1 7.5e-47 158.9 78.1 3.4 3 0 0 3 3 3 1 MAP7 (E-MAP-115) family ANF_receptor PF01094.26 MSTRG.26475.1_3 - 2.7e-43 148.3 0.0 4.2e-43 147.7 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan-Glu_bd PF10613.7 MSTRG.26475.1_3 - 4.7e-37 126.6 0.0 8.5e-37 125.7 0.0 1.4 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site Lig_chan PF00060.24 MSTRG.26475.1_3 - 1.2e-33 115.9 0.3 2e-33 115.2 0.3 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel SBP_bac_3 PF00497.18 MSTRG.26475.1_3 - 1.2e-18 67.2 0.0 2.3e-18 66.3 0.0 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 TPR_8 PF13181.4 MSTRG.9587.1_2 - 1.5e-09 37.2 2.5 6.9e-05 22.6 0.0 6.2 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.9587.1_2 - 3.5e-06 26.6 0.7 0.0088 16.0 0.0 5.3 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.9587.1_2 - 8.8e-05 22.1 0.1 0.044 13.7 0.0 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.9587.1_2 - 0.00018 22.0 0.0 0.035 14.7 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.9587.1_2 - 0.0002 21.8 0.1 0.31 11.8 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.9587.1_2 - 0.00067 19.7 0.3 0.29 11.3 0.0 3.4 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.4 MSTRG.9587.1_2 - 0.00081 19.5 0.1 1.1 9.7 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.9587.1_2 - 0.0011 18.6 0.0 0.92 9.3 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.9587.1_2 - 0.0036 17.7 0.3 34 4.9 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 MSTRG.9587.1_2 - 0.034 14.1 0.0 7.9 6.5 0.0 3.4 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.9587.1_2 - 0.1 13.1 0.0 26 5.6 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.16 MSTRG.9587.1_2 - 0.33 10.9 0.1 0.33 10.9 0.1 3.0 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_12 PF13424.4 MSTRG.9587.1_2 - 0.4 10.9 2.2 4.5 7.5 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat OSTMP1 PF09777.7 MSTRG.22691.3_2 - 2.6e-64 216.7 2.0 3.8e-64 216.2 2.0 1.2 1 0 0 1 1 1 1 Osteopetrosis-associated transmembrane protein 1 precursor Myosin_head PF00063.19 MSTRG.2761.1_3 - 3.6e-199 663.2 0.5 4.8e-199 662.8 0.5 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.25 MSTRG.2761.1_3 - 3.2e-07 29.4 19.3 0.0015 18.0 2.1 3.7 3 0 0 3 3 3 3 IQ calmodulin-binding motif AAA_22 PF13401.4 MSTRG.2761.1_3 - 0.0036 17.5 0.0 0.013 15.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 MSTRG.2761.1_3 - 0.16 12.2 0.2 0.67 10.2 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain SHIPPO-rpt PF07004.10 MSTRG.25175.1_1 - 0.00045 20.9 9.8 0.026 15.3 0.1 3.7 4 0 0 4 4 4 2 Sperm-tail PG-rich repeat Acyltransferase PF01553.19 MSTRG.8122.1_3 - 3.1e-12 46.2 0.0 5e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase EF-hand_6 PF13405.4 MSTRG.8122.1_3 - 0.00017 21.2 0.0 0.0026 17.4 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.30 MSTRG.8122.1_3 - 0.0021 17.4 0.0 0.013 14.8 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.4 MSTRG.8122.1_3 - 0.012 15.3 0.1 0.69 9.6 0.1 2.9 2 1 0 2 2 2 0 EF-hand domain pair RGS PF00615.17 MSTRG.1808.1_3 - 2.3e-34 118.1 3.0 3.1e-34 117.7 3.0 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF4686 PF15742.3 MSTRG.18208.1_2 - 2.7e-118 395.3 78.3 2.7e-118 395.3 78.3 6.2 4 1 1 5 5 5 1 Domain of unknown function (DUF4686) SNARE PF05739.17 MSTRG.18208.1_2 - 8.4 6.4 6.9 6.5 6.7 0.3 3.2 2 0 0 2 2 2 0 SNARE domain ubiquitin PF00240.21 MSTRG.4240.1_3 - 9.3e-28 95.6 0.4 1.3e-27 95.1 0.4 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 MSTRG.4240.1_3 - 1.3e-16 60.0 0.5 1.7e-16 59.6 0.5 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 MSTRG.4240.1_3 - 5.2e-05 23.5 0.1 0.00012 22.3 0.1 1.5 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 MSTRG.4240.1_3 - 0.1 12.6 0.1 0.2 11.7 0.1 1.4 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Mcm10 PF09332.9 MSTRG.20585.1_2 - 2.6e-136 454.6 1.4 2.6e-136 454.6 1.4 2.4 2 0 0 2 2 2 1 Mcm10 replication factor zf-primase PF09329.9 MSTRG.20585.1_2 - 5.2e-17 61.2 5.8 1e-16 60.3 5.8 1.5 1 0 0 1 1 1 1 Primase zinc finger YokU PF14122.4 MSTRG.20585.1_2 - 0.1 12.5 0.6 2.9 7.8 0.0 2.5 1 1 1 2 2 2 0 YokU-like protein, putative antitoxin SlyX PF04102.10 MSTRG.20585.1_2 - 0.11 13.0 2.8 0.4 11.2 2.8 2.0 1 0 0 1 1 1 0 SlyX Phage_Mu_Gam PF07352.10 MSTRG.20585.1_2 - 0.22 11.3 5.4 0.59 9.9 5.4 1.7 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein DUF342 PF03961.11 MSTRG.20585.1_2 - 1.1 7.7 5.1 2.1 6.7 5.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Plasmodium_Vir PF05795.9 MSTRG.20585.1_2 - 1.3 8.2 8.2 4.1 6.6 8.2 1.8 1 0 0 1 1 1 0 Plasmodium vivax Vir protein zf-CpG_bind_C PF12269.6 MSTRG.20585.1_2 - 1.9 8.1 10.6 0.27 10.8 1.9 2.7 2 0 0 2 2 2 0 CpG binding protein zinc finger C terminal domain AATF-Che1 PF13339.4 MSTRG.20585.1_2 - 2.2 8.8 8.7 1.2 9.7 4.2 2.7 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor DUF4140 PF13600.4 MSTRG.20585.1_2 - 5.1 7.5 10.5 0.56 10.5 5.0 2.3 2 0 0 2 2 1 0 N-terminal domain of unknown function (DUF4140) Evr1_Alr PF04777.11 MSTRG.20585.1_2 - 5.1 7.6 8.0 2.3 8.7 0.5 3.2 2 1 0 2 2 2 0 Erv1 / Alr family TFIIF_alpha PF05793.10 MSTRG.20585.1_2 - 8.2 4.8 19.5 23 3.2 19.5 1.8 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Zona_pellucida PF00100.21 MSTRG.5979.1_3 - 7.1e-49 166.7 4.0 1.3e-48 165.9 4.0 1.4 1 0 0 1 1 1 1 Zona pellucida-like domain FAST_2 PF08368.10 MSTRG.130.2_1 - 5.7e-29 100.7 0.1 2.5e-28 98.6 0.0 2.2 2 0 0 2 2 2 1 FAST kinase-like protein, subdomain 2 FAST_1 PF06743.13 MSTRG.130.2_1 - 2.6e-19 68.8 6.5 1e-18 66.8 0.2 4.4 5 0 0 5 5 5 1 FAST kinase-like protein, subdomain 1 TMEM52 PF14979.4 MSTRG.22759.1_2 - 0.056 13.2 0.0 0.069 12.9 0.0 1.0 1 0 0 1 1 1 0 Transmembrane 52 DUF2786 PF10979.6 MSTRG.27296.1_1 - 0.09 12.6 0.2 0.18 11.6 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2786) DJ-1_PfpI PF01965.22 MSTRG.22876.2_3 - 0.00011 21.9 0.2 0.0003 20.5 0.2 1.7 1 1 0 1 1 1 1 DJ-1/PfpI family Jiraiya PF15038.4 MSTRG.23690.1_2 - 4.1e-55 185.7 10.6 5.3e-55 185.3 10.6 1.1 1 0 0 1 1 1 1 Jiraiya DUF973 PF06157.9 MSTRG.23690.1_2 - 0.0051 15.8 0.0 0.0069 15.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF973) Phage_holin_3_6 PF07332.9 MSTRG.23690.1_2 - 0.96 9.4 10.1 0.034 14.0 3.2 1.9 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III bZIP_Maf PF03131.15 MSTRG.13100.1_1 - 4.3e-33 113.6 9.7 6.7e-33 112.9 9.7 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor Maf_N PF08383.9 MSTRG.13100.1_1 - 4.6e-08 32.6 0.0 8.3e-08 31.7 0.0 1.5 1 0 0 1 1 1 1 Maf N-terminal region HOOK PF05622.10 MSTRG.13100.1_1 - 0.00036 18.7 1.3 0.00049 18.3 1.3 1.1 1 0 0 1 1 1 1 HOOK protein KASH_CCD PF14662.4 MSTRG.13100.1_1 - 0.0048 16.6 2.0 0.0073 16.0 2.0 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH bZIP_1 PF00170.19 MSTRG.13100.1_1 - 0.0052 16.7 10.7 0.01 15.8 10.7 1.4 1 0 0 1 1 1 1 bZIP transcription factor DUF2353 PF09789.7 MSTRG.13100.1_1 - 0.082 12.2 5.0 0.13 11.6 5.0 1.2 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) DUF342 PF03961.11 MSTRG.13100.1_1 - 0.083 11.4 0.4 0.12 10.9 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) bZIP_2 PF07716.13 MSTRG.13100.1_1 - 0.34 10.9 6.9 0.93 9.5 6.9 1.8 1 0 0 1 1 1 0 Basic region leucine zipper Sporozoite_P67 PF05642.9 MSTRG.13869.2_2 - 0.66 7.8 1.9 0.85 7.5 1.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Phage_endo_I PF05367.9 MSTRG.12833.1_1 - 0.072 12.6 0.0 0.091 12.2 0.0 1.1 1 0 0 1 1 1 0 Phage endonuclease I Borrelia_P13 PF05628.10 MSTRG.24482.1_1 - 0.92 9.3 3.3 1.5 8.7 3.3 1.2 1 0 0 1 1 1 0 Borrelia membrane protein P13 PUF PF00806.17 MSTRG.9957.2_3 - 2.8e-72 234.4 7.9 1.3e-08 33.9 0.0 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.9 MSTRG.9957.2_3 - 0.0031 17.7 1.0 1.2 9.3 0.1 3.6 1 1 1 2 2 2 1 CPL (NUC119) domain DUF4821 PF16092.3 MSTRG.9957.2_3 - 0.021 14.4 0.1 0.055 13.0 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4821) FYVE_2 PF02318.14 MSTRG.9957.2_3 - 0.027 14.5 0.2 0.027 14.5 0.2 2.0 2 0 0 2 2 2 0 FYVE-type zinc finger sCache_2 PF17200.2 MSTRG.9957.2_3 - 0.037 13.7 0.0 24 4.6 0.0 3.6 4 0 0 4 4 4 0 Single Cache domain 2 RNA_pol_Rpb2_1 PF04563.13 MSTRG.9957.2_3 - 0.14 11.6 0.1 0.25 10.7 0.1 1.3 1 0 0 1 1 1 0 RNA polymerase beta subunit Mucin PF01456.15 MSTRG.11615.1_3 - 0.063 13.1 9.5 0.077 12.8 9.5 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein GalP_UDP_transf PF01087.20 MSTRG.65.5_2 - 0.0069 16.7 3.5 0.53 10.5 1.1 2.6 2 0 0 2 2 2 2 Galactose-1-phosphate uridyl transferase, N-terminal domain E7 PF00527.16 MSTRG.65.5_2 - 0.87 9.7 26.2 2 8.5 6.2 4.4 4 0 0 4 4 4 0 E7 protein, Early protein zf-C2HC_2 PF13913.4 MSTRG.65.5_2 - 3.4 7.5 6.3 0.32 10.8 0.4 2.2 2 0 0 2 2 2 0 zinc-finger of a C2HC-type ST7 PF04184.10 MSTRG.65.5_2 - 4.4 5.5 5.7 0.56 8.4 1.3 1.6 2 0 0 2 2 2 0 ST7 protein DFP PF04127.13 MSTRG.21012.1_2 - 1.2e-19 70.7 0.0 1.7e-10 40.9 0.0 2.2 2 0 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein RPEL PF02755.13 MSTRG.12777.1_3 - 7.9e-08 31.6 0.1 1.2e-07 31.0 0.1 1.3 1 0 0 1 1 1 1 RPEL repeat SPRY PF00622.26 MSTRG.27138.3_1 - 1.1e-19 70.6 0.1 2e-19 69.7 0.1 1.5 1 0 0 1 1 1 1 SPRY domain AAA_33 PF13671.4 MSTRG.27138.3_1 - 1.3e-12 47.9 0.0 2.6e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain SAP PF02037.25 MSTRG.27138.3_1 - 2.4e-11 42.9 3.4 2.4e-11 42.9 3.4 1.9 2 0 0 2 2 2 1 SAP domain Antimicrobial_2 PF08023.10 MSTRG.27138.3_2 - 0.27 11.7 5.9 5.7 7.4 5.9 2.5 1 1 0 1 1 1 0 Frog antimicrobial peptide Cyclin_N PF00134.21 MSTRG.3746.2_3 - 2.8e-21 75.5 2.0 3e-18 65.7 0.2 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain HRDC PF00570.21 MSTRG.3746.2_3 - 0.43 10.4 1.4 2.3 8.1 0.2 2.2 2 0 0 2 2 2 0 HRDC domain Myosin_head PF00063.19 MSTRG.24825.4_1 - 5.4e-186 619.6 10.9 1.3e-158 529.2 2.6 2.2 2 0 0 2 2 2 2 Myosin head (motor domain) RA PF00788.21 MSTRG.24825.4_1 - 8.5e-13 48.6 0.1 1.1e-10 41.8 0.0 2.8 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain C1_1 PF00130.20 MSTRG.24825.4_1 - 5.5e-08 32.5 7.4 1.4e-07 31.1 7.4 1.8 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) RhoGAP PF00620.25 MSTRG.24825.4_1 - 1.6e-05 24.6 0.1 8.6e-05 22.3 0.0 2.4 2 0 0 2 2 2 1 RhoGAP domain C1_2 PF03107.14 MSTRG.24825.4_1 - 0.0015 18.6 6.1 0.0036 17.4 6.1 1.6 1 0 0 1 1 1 1 C1 domain IQ PF00612.25 MSTRG.24825.4_1 - 0.0018 17.8 12.0 0.43 10.4 2.0 3.9 3 0 0 3 3 3 2 IQ calmodulin-binding motif Zf_RING PF16744.3 MSTRG.24825.4_1 - 0.13 12.3 8.7 0.4 10.7 7.7 2.3 2 0 0 2 2 2 0 KIAA1045 RING finger AAA_22 PF13401.4 MSTRG.24825.4_1 - 0.15 12.2 0.3 2.7 8.1 0.0 2.9 2 0 0 2 2 2 0 AAA domain zf-RING_9 PF13901.4 MSTRG.24825.4_1 - 3.8 7.3 12.3 1.1 9.1 8.1 2.3 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon Y_phosphatase PF00102.25 MSTRG.11967.1_1 - 4.2e-149 494.4 0.0 1.5e-86 289.7 0.0 2.3 2 0 0 2 2 2 2 Protein-tyrosine phosphatase MAM PF00629.21 MSTRG.11967.1_1 - 3.5e-30 104.8 0.0 7.5e-30 103.8 0.0 1.6 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu fn3 PF00041.19 MSTRG.11967.1_1 - 2.3e-23 82.2 0.9 2.6e-08 34.0 0.0 5.1 4 1 1 5 5 5 3 Fibronectin type III domain DSPc PF00782.18 MSTRG.11967.1_1 - 5.1e-08 32.7 0.2 0.0015 18.2 0.1 2.7 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain I-set PF07679.14 MSTRG.11967.1_1 - 1.5e-07 31.2 0.0 4.2e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 MSTRG.11967.1_1 - 6.8e-07 29.2 0.1 1.5e-06 28.1 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.11967.1_1 - 2.2e-06 28.1 0.1 5.8e-06 26.7 0.1 1.8 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.11967.1_1 - 5.1e-05 23.4 0.0 0.00013 22.1 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Y_phosphatase3 PF13350.4 MSTRG.11967.1_1 - 0.0012 18.7 0.0 0.054 13.3 0.0 2.3 2 0 0 2 2 2 1 Tyrosine phosphatase family PTPlike_phytase PF14566.4 MSTRG.11967.1_1 - 0.034 14.2 0.0 0.17 11.9 0.0 2.1 2 0 0 2 2 2 0 Inositol hexakisphosphate Protocadherin PF08374.9 MSTRG.11967.1_1 - 0.093 12.6 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Protocadherin EphA2_TM PF14575.4 MSTRG.11967.1_1 - 0.1 13.3 0.0 0.29 11.8 0.0 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Hydrolase PF00702.24 MSTRG.16452.1_1 - 1.7e-05 25.1 0.0 2.5e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase RRM_1 PF00076.20 MSTRG.18494.2_3 - 3.2e-57 190.1 0.3 8.2e-18 63.9 0.0 5.3 4 1 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 MSTRG.18494.2_3 - 8.7e-06 25.6 0.7 0.29 11.1 0.1 3.9 3 0 0 3 3 3 2 RNA binding motif Nup35_RRM_2 PF14605.4 MSTRG.18494.2_3 - 0.0031 17.3 0.0 1.3 8.9 0.0 2.5 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif BUD22 PF09073.8 MSTRG.18494.2_3 - 0.0055 16.0 26.2 0.0055 16.0 26.2 2.8 3 0 0 3 3 3 1 BUD22 Nop14 PF04147.10 MSTRG.18494.2_3 - 0.017 13.3 31.2 0.035 12.2 31.2 1.5 1 0 0 1 1 1 0 Nop14-like family HLH PF00010.24 MSTRG.14214.1_3 - 4.7e-15 55.2 1.0 1.1e-14 54.0 1.0 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PRKG1_interact PF15898.3 MSTRG.14214.1_3 - 0.045 14.5 0.4 0.1 13.4 0.4 1.5 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain ZapB PF06005.10 MSTRG.14214.1_3 - 0.048 14.0 0.3 0.1 12.9 0.3 1.5 1 0 0 1 1 1 0 Cell division protein ZapB GIT_CC PF16559.3 MSTRG.14214.1_3 - 0.3 11.0 1.9 0.73 9.8 1.9 1.6 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor CABIT PF12736.5 MSTRG.19988.1_2 - 6.1e-18 65.0 0.0 9.7e-18 64.3 0.0 1.3 1 0 0 1 1 1 1 Cell-cycle sustaining, positive selection, Pkinase_Tyr PF07714.15 MSTRG.1239.5_2 - 5.2e-102 340.4 0.0 9.3e-102 339.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.1239.5_2 - 6.7e-45 153.4 0.0 1.1e-44 152.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 MSTRG.1239.5_2 - 0.00028 20.8 0.0 0.00058 19.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 MSTRG.1239.5_2 - 0.0012 18.8 0.1 0.0043 17.0 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.1239.5_2 - 0.0096 16.4 0.0 0.023 15.2 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 MSTRG.1239.5_2 - 0.064 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin V-set domain Ig_2 PF13895.4 MSTRG.1239.5_2 - 0.084 13.1 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain Phage_holin_3_6 PF07332.9 MSTRG.1239.5_2 - 0.56 10.1 1.9 0.81 9.6 0.0 2.0 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Prominin PF05478.9 MSTRG.4154.1_2 - 0.048 11.5 0.0 0.06 11.2 0.0 1.0 1 0 0 1 1 1 0 Prominin Prominin PF05478.9 MSTRG.4154.1_3 - 1.2e-26 92.9 0.3 1.5e-26 92.5 0.3 1.1 1 0 0 1 1 1 1 Prominin Glyco_transf_29 PF00777.16 MSTRG.15333.1_3 - 3.3e-77 259.3 0.0 4.4e-77 258.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Stealth_CR4 PF17103.3 MSTRG.18622.1_2 - 3.6e-18 65.1 0.2 5e-18 64.7 0.2 1.2 1 0 0 1 1 1 1 Stealth protein CR4, conserved region 4 DUF815 PF05673.11 MSTRG.18622.1_2 - 0.013 14.5 0.3 0.015 14.4 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) SNARE PF05739.17 MSTRG.18622.1_2 - 0.11 12.3 0.5 0.19 11.7 0.3 1.4 1 1 0 1 1 1 0 SNARE domain p450 PF00067.20 MSTRG.15072.5_3 - 6.2e-70 236.1 0.0 9.1e-70 235.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Enkurin PF13864.4 MSTRG.1840.1_1 - 3e-26 91.6 2.4 6.3e-26 90.5 2.4 1.6 1 0 0 1 1 1 1 Calmodulin-binding DUF945 PF06097.9 MSTRG.4062.1_1 - 8.2e-05 21.8 0.0 4.9 6.0 0.0 5.2 4 2 1 5 5 5 3 Bacterial protein of unknown function (DUF945) Furin-like PF00757.18 MSTRG.23640.1_2 - 0.11 12.2 7.1 0.17 11.6 7.1 1.3 1 0 0 1 1 1 0 Furin-like cysteine rich region FANCI_S1-cap PF14674.4 MSTRG.10690.2_3 - 0.02 14.8 4.5 4.1e+02 1.0 0.0 6.7 9 0 0 9 9 9 0 FANCI solenoid 1 cap DUF3500 PF12006.6 MSTRG.25657.1_2 - 0.11 11.9 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3500) LPAM_1 PF08139.10 MSTRG.25657.1_3 - 0.073 13.5 0.2 0.17 12.3 0.0 1.7 2 0 0 2 2 2 0 Prokaryotic membrane lipoprotein lipid attachment site C2-set_2 PF08205.10 MSTRG.23364.2_3 - 1e-13 51.0 0.1 2.4e-13 49.8 0.1 1.6 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.4 MSTRG.23364.2_3 - 2.6e-12 46.8 0.1 2.5e-06 27.6 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.23364.2_3 - 3.7e-12 46.6 0.2 5.8e-06 26.7 0.1 2.4 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 MSTRG.23364.2_3 - 4.7e-11 42.6 0.2 0.00021 21.3 0.0 3.0 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 MSTRG.23364.2_3 - 5.3e-11 42.5 0.1 2.4e-06 27.5 0.1 2.6 2 1 0 2 2 2 2 Immunoglobulin V-set domain I-set PF07679.14 MSTRG.23364.2_3 - 6.6e-07 29.2 0.0 0.02 14.8 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin I-set domain C1-set PF07654.13 MSTRG.23364.2_3 - 0.0086 16.4 0.0 0.023 15.0 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Izumo-Ig PF16706.3 MSTRG.23364.2_3 - 0.12 12.3 0.0 0.24 11.3 0.0 1.7 1 1 0 1 1 1 0 Izumo-like Immunoglobulin domain Myb_DNA-binding PF00249.29 MSTRG.25741.2_1 - 8e-06 25.8 0.0 1.2e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 MSTRG.25741.2_1 - 0.0027 17.8 0.0 0.0039 17.3 0.0 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain UQ_con PF00179.24 MSTRG.8431.1_2 - 0.054 13.0 0.0 0.085 12.4 0.0 1.3 1 1 0 1 1 1 0 Ubiquitin-conjugating enzyme Aldolase_II PF00596.19 MSTRG.17566.1_1 - 4.4e-46 157.0 0.0 5.6e-46 156.7 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain PIRT PF15099.4 MSTRG.17566.1_1 - 0.096 12.1 0.1 0.18 11.2 0.1 1.4 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family Spectrin PF00435.19 MSTRG.9384.1_2 - 1.1e-279 906.4 173.2 9.1e-21 74.2 0.9 17.4 17 0 0 17 17 17 17 Spectrin repeat CH PF00307.29 MSTRG.9384.1_2 - 2.2e-49 166.1 5.8 8.7e-25 86.9 0.1 3.9 5 0 0 5 5 5 2 Calponin homology (CH) domain PH_9 PF15410.4 MSTRG.9384.1_2 - 4e-21 75.5 0.0 1.7e-20 73.4 0.0 2.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 MSTRG.9384.1_2 - 8.2e-15 55.1 0.0 3.1e-14 53.2 0.0 2.0 2 0 0 2 2 2 1 PH domain CAMSAP_CH PF11971.6 MSTRG.9384.1_2 - 8.9e-07 28.5 0.1 0.00011 21.8 0.0 2.8 2 0 0 2 2 2 1 CAMSAP CH domain FAM195 PF14799.4 MSTRG.9384.1_2 - 0.12 12.6 1.3 3.6 7.8 0.1 4.0 2 0 0 2 2 2 0 FAM195 family V-SNARE_C PF12352.6 MSTRG.9384.1_2 - 0.87 9.8 7.0 23 5.2 0.0 4.7 4 0 0 4 4 4 0 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.11 MSTRG.9384.1_2 - 7.2 6.5 12.8 32 4.4 0.0 5.4 4 0 0 4 4 4 0 Sec20 DUF1515 PF07439.9 MSTRG.9384.1_2 - 9.5 6.1 6.6 12 5.8 0.2 4.6 5 0 0 5 5 5 0 Protein of unknown function (DUF1515) AFG1_ATPase PF03969.14 MSTRG.8915.1_1 - 1.9e-50 171.6 0.0 2.5e-50 171.3 0.0 1.1 1 0 0 1 1 1 1 AFG1-like ATPase AAA_16 PF13191.4 MSTRG.8915.1_1 - 9.8e-05 22.7 0.1 0.039 14.2 0.1 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 MSTRG.8915.1_1 - 0.013 15.7 0.0 0.027 14.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA PF00004.27 MSTRG.8915.1_1 - 0.021 15.1 0.0 0.044 14.1 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.16 MSTRG.8915.1_1 - 0.029 14.2 0.1 0.051 13.4 0.1 1.4 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_19 PF13245.4 MSTRG.8915.1_1 - 0.058 13.6 0.2 1.5 9.0 0.2 2.2 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.4 MSTRG.8915.1_1 - 0.084 13.3 0.0 0.4 11.1 0.0 1.9 1 1 1 2 2 2 0 AAA domain DUF2075 PF09848.7 MSTRG.8915.1_1 - 0.088 11.9 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DUF3915 PF13054.4 MSTRG.8915.1_1 - 0.094 12.6 0.4 0.2 11.5 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) TniB PF05621.9 MSTRG.8915.1_1 - 0.12 11.4 0.0 0.18 10.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein ResIII PF04851.13 MSTRG.8915.1_1 - 0.13 12.1 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit RNA_helicase PF00910.20 MSTRG.8915.1_1 - 0.15 12.4 0.2 0.44 10.8 0.1 2.0 2 1 1 3 3 3 0 RNA helicase UvrD-helicase PF00580.19 MSTRG.8915.1_1 - 0.16 11.4 0.0 0.41 10.0 0.0 1.6 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain Mrx7 PF10906.6 MSTRG.8915.1_1 - 0.19 11.9 0.1 0.19 11.9 0.1 1.7 2 0 0 2 2 1 0 MIOREX complex component 7 DUF2207 PF09972.7 MSTRG.27584.1_1 - 0.0074 15.0 0.0 0.012 14.3 0.0 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF4366 PF14283.4 MSTRG.27584.1_1 - 0.011 15.1 0.0 0.011 15.1 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) Herpes_gE PF02480.14 MSTRG.27584.1_1 - 0.031 12.9 0.0 0.042 12.5 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Endomucin PF07010.10 MSTRG.27584.1_1 - 2.3 8.0 18.5 0.023 14.6 9.2 1.9 2 0 0 2 2 2 0 Endomucin SH3_2 PF07653.15 MSTRG.9483.1_3 - 2.1e-09 36.8 0.0 3.2e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 MSTRG.9483.1_3 - 0.0055 16.4 0.0 0.0086 15.8 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain ParA PF10609.7 MSTRG.1354.3_1 - 1e-97 326.3 0.2 2.2e-97 325.2 0.2 1.5 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.21 MSTRG.1354.3_1 - 4.2e-10 39.7 0.0 1.3e-09 38.1 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.4 MSTRG.1354.3_1 - 3.3e-07 30.3 0.1 2.5e-05 24.1 0.1 2.2 2 0 0 2 2 2 1 AAA domain MipZ PF09140.9 MSTRG.1354.3_1 - 9.5e-06 25.0 0.0 1.6e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 ATPase MipZ Fer4_NifH PF00142.16 MSTRG.1354.3_1 - 2.5e-05 23.7 0.0 0.023 14.0 0.0 2.2 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArsA_ATPase PF02374.13 MSTRG.1354.3_1 - 0.00047 19.4 0.0 0.015 14.4 0.2 2.8 3 0 0 3 3 3 1 Anion-transporting ATPase AAA_25 PF13481.4 MSTRG.1354.3_1 - 0.0028 17.1 0.1 0.0055 16.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain VirC1 PF07015.9 MSTRG.1354.3_1 - 0.046 12.9 0.0 0.2 10.8 0.0 1.8 2 0 0 2 2 2 0 VirC1 protein Complex1_LYR_2 PF13233.4 MSTRG.22925.1_2 - 9e-20 71.1 0.2 1.3e-19 70.5 0.2 1.3 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.13 MSTRG.22925.1_2 - 4.4e-06 26.5 0.3 7.3e-06 25.8 0.3 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) V-ATPase_H_N PF03224.12 MSTRG.12179.1_3 - 2e-107 359.0 7.6 2e-107 359.0 7.6 1.8 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.6 MSTRG.12179.1_3 - 2e-45 153.5 0.2 2e-45 153.5 0.2 2.4 3 0 0 3 3 3 1 V-ATPase subunit H Arm PF00514.21 MSTRG.12179.1_3 - 5.5e-06 26.1 0.5 0.0087 15.9 0.0 4.4 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat DUF2326 PF10088.7 MSTRG.12179.1_3 - 0.0041 16.7 0.5 0.012 15.1 0.3 1.9 1 1 1 2 2 2 1 Uncharacterised protein conserved in bacteria (DUF2326) Arm_2 PF04826.11 MSTRG.12179.1_3 - 0.0041 16.5 0.1 0.014 14.7 0.0 1.9 2 0 0 2 2 2 1 Armadillo-like DUF4364 PF14277.4 MSTRG.12179.1_3 - 0.01 15.5 0.3 0.027 14.1 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) SPOB_ab PF14682.4 MSTRG.12179.1_3 - 0.034 14.1 0.9 0.034 14.1 0.9 2.2 2 1 1 3 3 3 0 Sporulation initiation phospho-transferase B, C-terminal UCH PF00443.27 MSTRG.12179.1_3 - 0.24 10.7 1.6 0.22 10.9 0.1 1.6 2 0 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase DUF3585 PF12130.6 MSTRG.4471.1_1 - 7.6e-35 119.9 22.8 7.6e-35 119.9 22.8 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3585) CH PF00307.29 MSTRG.4471.1_1 - 5.1e-22 78.0 0.0 1.2e-21 76.8 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 MSTRG.4471.1_1 - 2.4e-11 43.2 0.0 5.4e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain LIM PF00412.20 MSTRG.4471.1_1 - 1.8e-07 31.1 3.5 4.1e-07 30.0 3.5 1.6 1 0 0 1 1 1 1 LIM domain FAD_binding_3 PF01494.17 MSTRG.4471.1_1 - 5.5e-05 22.5 0.5 9e-05 21.8 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.12 MSTRG.4471.1_1 - 0.00037 19.7 0.0 0.00066 18.9 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 MSTRG.4471.1_1 - 0.00065 18.9 0.0 0.0012 18.0 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 MSTRG.4471.1_1 - 0.0021 17.6 0.0 0.085 12.3 0.1 2.5 1 1 1 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.12 MSTRG.4471.1_1 - 0.0094 14.5 0.0 0.018 13.6 0.0 1.4 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.4 MSTRG.4471.1_1 - 0.0094 16.0 0.0 0.022 14.8 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain CH_2 PF06294.9 MSTRG.4471.1_1 - 0.0098 15.9 0.0 0.035 14.1 0.0 2.0 2 0 0 2 2 1 1 CH-like domain in sperm protein Lar_restr_allev PF14354.4 MSTRG.4471.1_1 - 0.017 15.3 1.6 0.048 13.9 1.6 1.7 1 0 0 1 1 1 0 Restriction alleviation protein Lar FAD_binding_2 PF00890.22 MSTRG.4471.1_1 - 0.021 13.8 0.3 0.045 12.7 0.0 1.7 2 0 0 2 2 2 0 FAD binding domain NAD_binding_7 PF13241.4 MSTRG.4471.1_1 - 0.08 13.3 0.0 0.27 11.6 0.0 1.8 1 0 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox PF00070.25 MSTRG.4471.1_1 - 0.12 12.8 0.0 0.43 11.0 0.0 2.0 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase CLASP_N PF12348.6 MSTRG.9970.9_1 - 1.5e-48 165.3 0.0 1.8e-37 129.0 0.1 2.2 2 0 0 2 2 2 2 CLASP N terminal HEAT PF02985.20 MSTRG.9970.9_1 - 4.6e-06 26.3 3.8 0.0036 17.3 0.0 4.8 5 0 0 5 5 5 1 HEAT repeat MOR2-PAG1_C PF14225.4 MSTRG.9970.9_1 - 0.0011 18.8 0.0 0.14 11.8 0.0 2.2 2 0 0 2 2 2 1 Cell morphogenesis C-terminal HEAT_EZ PF13513.4 MSTRG.9970.9_1 - 0.0045 17.3 0.1 9.5 6.7 0.0 3.6 3 0 0 3 3 3 1 HEAT-like repeat HEAT_2 PF13646.4 MSTRG.9970.9_1 - 0.018 15.3 0.1 0.69 10.2 0.0 3.4 3 2 1 4 4 4 0 HEAT repeats Arm PF00514.21 MSTRG.9970.9_1 - 0.12 12.3 0.1 8.3 6.5 0.0 3.3 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.18 MSTRG.9970.9_1 - 0.14 10.6 0.3 8.8 4.6 0.0 2.9 2 1 2 4 4 4 0 Adaptin N terminal region Aldo_ket_red PF00248.19 MSTRG.21655.1_3 - 1.6e-45 155.4 0.0 2.2e-45 154.9 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family ABC_membrane PF00664.21 MSTRG.6515.3_1 - 6.5e-53 180.0 2.7 2.7e-52 178.0 2.7 1.8 1 1 0 1 1 1 1 ABC transporter transmembrane region DRMBL PF07522.12 MSTRG.26703.1_3 - 3.2e-09 36.9 0.0 3.8e-07 30.2 0.1 2.5 2 0 0 2 2 2 2 DNA repair metallo-beta-lactamase RMMBL PF07521.10 MSTRG.26703.1_3 - 0.0048 16.7 0.0 0.013 15.3 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.5 MSTRG.26703.1_3 - 0.18 11.2 0.0 0.43 9.9 0.0 1.7 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Med26 PF08711.9 MSTRG.20544.1_3 - 1.2e-13 50.8 1.4 2.5e-13 49.7 1.4 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain DUF3480 PF11979.6 MSTRG.20544.1_3 - 0.035 13.0 0.1 0.04 12.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3480) TGFb_propeptide PF00688.16 MSTRG.27125.4_2 - 2.4e-43 148.6 0.9 3.6e-43 148.0 0.9 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 MSTRG.27125.4_2 - 4.5e-24 85.2 3.5 9.5e-24 84.2 3.5 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain CBFB_NFYA PF02045.13 MSTRG.22287.1_1 - 0.021 15.4 1.4 0.036 14.6 1.4 1.4 1 0 0 1 1 1 0 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Tctex-1 PF03645.11 MSTRG.22287.1_2 - 6e-29 100.2 1.0 8.3e-29 99.7 1.0 1.2 1 0 0 1 1 1 1 Tctex-1 family PMT PF02366.16 MSTRG.17719.1_2 - 9.4e-85 284.0 14.0 1.7e-84 283.1 14.0 1.4 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.3 MSTRG.17719.1_2 - 9.9e-57 191.6 7.4 9.9e-57 191.6 7.4 1.8 2 0 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.17 MSTRG.17719.1_2 - 1.7e-20 73.5 0.6 3e-20 72.7 0.6 1.3 1 0 0 1 1 1 1 MIR domain zf-DHHC PF01529.18 MSTRG.13452.1_1 - 2e-36 124.9 14.1 2e-36 124.9 14.1 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase CAP_N PF01213.17 MSTRG.103.2_2 - 6.1e-105 351.1 0.0 8.6e-105 350.6 0.0 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.9 MSTRG.103.2_2 - 1.9e-63 212.7 0.6 2.6e-63 212.2 0.6 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal VPS28 PF03997.10 MSTRG.103.2_3 - 2e-64 216.6 0.2 2.6e-64 216.3 0.2 1.1 1 0 0 1 1 1 1 VPS28 protein Dishevelled PF02377.13 MSTRG.23281.1_2 - 9.1e-54 182.1 22.9 9.1e-54 182.1 22.9 2.3 3 0 0 3 3 3 1 Dishevelled specific domain Dsh_C PF12316.6 MSTRG.23281.1_2 - 3.5e-50 171.2 26.2 3.5e-50 171.2 26.2 2.6 2 0 0 2 2 2 1 Segment polarity protein dishevelled (Dsh) C terminal DIX PF00778.15 MSTRG.23281.1_2 - 1.8e-32 110.9 0.7 3.4e-32 110.0 0.3 1.7 2 0 0 2 2 2 1 DIX domain PDZ PF00595.22 MSTRG.23281.1_2 - 3e-18 65.8 0.3 4.7e-18 65.2 0.3 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) DEP PF00610.19 MSTRG.23281.1_2 - 1.8e-17 63.0 0.1 3.6e-17 62.0 0.1 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PDZ_2 PF13180.4 MSTRG.23281.1_2 - 0.011 15.9 0.2 0.022 14.9 0.2 1.5 1 0 0 1 1 1 0 PDZ domain Shufflon_N PF04917.10 MSTRG.23281.1_2 - 0.03 13.6 0.1 0.05 12.9 0.1 1.2 1 0 0 1 1 1 0 Bacterial shufflon protein, N-terminal constant region TGFb_propeptide PF00688.16 MSTRG.20386.1_1 - 3.6e-92 308.4 0.0 5.3e-92 307.9 0.0 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 MSTRG.20386.1_1 - 1e-35 122.6 0.6 1e-35 122.6 0.6 2.2 2 0 0 2 2 2 1 Transforming growth factor beta like domain PHD PF00628.27 MSTRG.27664.1_2 - 1.5e-09 37.5 10.0 2.8e-09 36.6 10.0 1.5 1 0 0 1 1 1 1 PHD-finger C1_1 PF00130.20 MSTRG.27664.1_2 - 0.00011 21.9 3.5 0.00011 21.9 3.5 2.1 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-PHD-like PF15446.4 MSTRG.27664.1_2 - 0.00083 18.9 3.7 0.0016 17.9 3.7 1.5 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain PHD_2 PF13831.4 MSTRG.27664.1_2 - 0.0035 16.7 5.4 0.0095 15.3 5.4 1.8 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.4 MSTRG.27664.1_2 - 0.0045 16.7 3.7 0.011 15.5 3.7 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 PHD_4 PF16866.3 MSTRG.27664.1_2 - 0.013 15.5 8.9 0.038 14.0 8.9 1.9 1 1 0 1 1 1 0 PHD-finger zf-RING_9 PF13901.4 MSTRG.27664.1_2 - 0.074 12.9 5.9 0.14 11.9 5.9 1.4 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon zf-4CXXC_R1 PF10497.7 MSTRG.27664.1_2 - 0.1 12.7 4.7 0.2 11.8 4.7 1.4 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zinc_ribbon_15 PF17032.3 MSTRG.27664.1_2 - 0.23 12.1 3.7 0.56 10.9 3.7 1.6 1 0 0 1 1 1 0 zinc-ribbon family FYVE_2 PF02318.14 MSTRG.27664.1_2 - 0.32 11.1 5.0 0.72 10.0 5.0 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger zf-C2H2 PF00096.24 MSTRG.17210.2_2 - 5.5e-15 54.8 31.5 9.8e-05 22.5 1.4 5.9 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.17210.2_2 - 3e-09 36.8 28.9 5e-07 29.8 0.5 5.1 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.17210.2_2 - 1.7e-06 28.2 28.0 0.1 13.3 1.2 6.0 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.17210.2_2 - 0.00033 20.8 23.6 0.08 13.2 0.2 5.7 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.3 MSTRG.17210.2_2 - 0.37 11.2 9.9 2.4 8.6 0.2 4.2 4 0 0 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.5 MSTRG.17210.2_2 - 1.5 9.2 25.8 2.9 8.3 0.5 5.6 5 0 0 5 5 5 0 Zinc-finger of C2H2 type Hormone_recep PF00104.28 MSTRG.17225.1_2 - 5.9e-23 81.4 0.0 1.1e-22 80.6 0.0 1.4 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor ODV-E18 PF10717.7 MSTRG.18417.1_2 - 0.13 12.0 1.5 0.33 10.7 1.5 1.6 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 TPR_6 PF13174.4 MSTRG.1458.1_3 - 0.00074 19.9 0.0 0.0013 19.0 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.1458.1_3 - 0.0034 17.2 0.0 0.0078 16.1 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.1458.1_3 - 0.0048 17.5 0.0 0.0091 16.6 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.1458.1_3 - 0.006 16.5 0.0 0.013 15.5 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.1458.1_3 - 0.015 15.0 0.0 0.031 14.0 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.1458.1_3 - 0.03 14.5 0.0 0.063 13.4 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.1458.1_3 - 0.05 13.7 0.1 0.093 12.8 0.1 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 NTPase_1 PF03266.13 MSTRG.7826.1_2 - 2.6e-59 199.7 0.1 3.2e-59 199.5 0.1 1.1 1 0 0 1 1 1 1 NTPase AAA_16 PF13191.4 MSTRG.7826.1_2 - 1.4e-05 25.4 0.0 2.6e-05 24.5 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 MSTRG.7826.1_2 - 1.5e-05 25.2 0.0 3.6e-05 23.9 0.0 1.5 2 0 0 2 2 1 1 AAA domain AAA PF00004.27 MSTRG.7826.1_2 - 4.3e-05 23.8 0.0 0.0001 22.6 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.10 MSTRG.7826.1_2 - 0.00014 21.1 0.0 0.00023 20.4 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.12 MSTRG.7826.1_2 - 0.00024 21.0 0.0 0.0021 17.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) NACHT PF05729.10 MSTRG.7826.1_2 - 0.00036 20.4 0.0 0.0006 19.6 0.0 1.3 1 0 0 1 1 1 1 NACHT domain ArgK PF03308.14 MSTRG.7826.1_2 - 0.00085 18.2 0.0 0.0014 17.6 0.0 1.2 1 0 0 1 1 1 1 ArgK protein AAA_19 PF13245.4 MSTRG.7826.1_2 - 0.0012 19.0 0.0 0.0027 17.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.4 MSTRG.7826.1_2 - 0.0015 18.4 0.0 0.22 11.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.20 MSTRG.7826.1_2 - 0.0019 18.4 0.0 0.004 17.4 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.4 MSTRG.7826.1_2 - 0.0022 18.4 0.1 0.0036 17.7 0.1 1.3 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.18 MSTRG.7826.1_2 - 0.0045 16.8 0.0 0.0069 16.2 0.0 1.2 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_30 PF13604.4 MSTRG.7826.1_2 - 0.0048 16.5 0.0 0.011 15.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.4 MSTRG.7826.1_2 - 0.0074 16.3 0.1 0.016 15.2 0.1 1.5 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.21 MSTRG.7826.1_2 - 0.011 15.6 0.0 0.022 14.7 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase NB-ARC PF00931.20 MSTRG.7826.1_2 - 0.012 14.6 0.0 0.02 13.8 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain IstB_IS21 PF01695.15 MSTRG.7826.1_2 - 0.012 15.3 0.0 0.03 13.9 0.0 1.6 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_25 PF13481.4 MSTRG.7826.1_2 - 0.014 14.8 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain TsaE PF02367.15 MSTRG.7826.1_2 - 0.015 15.2 0.0 0.026 14.4 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE cobW PF02492.17 MSTRG.7826.1_2 - 0.035 13.6 0.0 0.05 13.0 0.0 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ATPase_2 PF01637.16 MSTRG.7826.1_2 - 0.05 13.4 0.0 0.072 12.9 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Mg_chelatase PF01078.19 MSTRG.7826.1_2 - 0.072 12.3 0.0 0.24 10.6 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_17 PF13207.4 MSTRG.7826.1_2 - 0.081 13.2 0.1 0.13 12.5 0.1 1.3 1 0 0 1 1 1 0 AAA domain MobB PF03205.12 MSTRG.7826.1_2 - 0.087 12.6 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B SRPRB PF09439.8 MSTRG.7826.1_2 - 0.089 12.1 0.0 3.4 6.9 0.0 2.1 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_28 PF13521.4 MSTRG.7826.1_2 - 0.099 12.8 0.1 0.16 12.1 0.1 1.3 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.16 MSTRG.7826.1_2 - 0.1 12.2 0.0 0.53 9.9 0.0 1.9 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase DUF258 PF03193.14 MSTRG.7826.1_2 - 0.11 12.2 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Roc PF08477.11 MSTRG.7826.1_2 - 0.11 12.6 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.4 MSTRG.7826.1_2 - 0.12 11.9 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.4 MSTRG.7826.1_2 - 0.13 11.8 0.0 0.24 10.9 0.0 1.4 2 0 0 2 2 1 0 AAA domain ATP_bind_1 PF03029.15 MSTRG.7826.1_2 - 0.14 11.7 0.1 0.22 11.1 0.1 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein TNFR_c6 PF00020.16 MSTRG.16511.2_1 - 1.5e-15 57.2 56.3 2e-08 34.4 11.2 4.2 4 0 0 4 4 4 3 TNFR/NGFR cysteine-rich region Death PF00531.20 MSTRG.16511.2_1 - 1.4e-09 37.8 0.1 2.5e-09 37.1 0.1 1.3 1 0 0 1 1 1 1 Death domain PRA1 PF03208.17 MSTRG.13064.1_2 - 7.5e-39 132.5 4.9 1e-38 132.0 4.9 1.2 1 0 0 1 1 1 1 PRA1 family protein DUF3487 PF11990.6 MSTRG.13064.1_2 - 4.7 7.0 9.7 0.72 9.6 1.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3487) UCH PF00443.27 MSTRG.7147.1_1 - 4.1e-50 170.5 1.6 8.4e-50 169.5 0.0 2.1 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 MSTRG.7147.1_1 - 6.8e-10 38.9 5.9 7.3e-10 38.8 1.0 2.6 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase MerR-DNA-bind PF09278.9 MSTRG.7147.1_1 - 0.056 13.8 0.8 7.3 7.1 0.0 2.9 2 0 0 2 2 2 0 MerR, DNA binding Peptidase_C98 PF15499.4 MSTRG.7147.1_1 - 0.7 9.2 3.2 12 5.2 0.3 2.7 3 0 0 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase CTNNB1_binding PF08347.9 MSTRG.16646.1_1 - 3.5e-101 337.4 3.1 3.5e-101 337.4 3.1 3.0 2 1 0 3 3 3 1 N-terminal CTNNB1 binding HMG_box PF00505.17 MSTRG.16646.1_1 - 2e-21 76.0 0.8 4.7e-21 74.8 0.8 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 MSTRG.16646.1_1 - 2.2e-08 34.5 0.9 4.2e-08 33.5 0.9 1.5 1 0 0 1 1 1 1 HMG-box domain Kelch_1 PF01344.23 MSTRG.11391.1_2 - 1.2e-78 258.4 14.5 1e-15 56.9 0.1 6.8 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 MSTRG.11391.1_2 - 6.6e-44 146.7 6.1 3.3e-08 33.4 0.0 6.5 3 2 3 6 6 6 5 Kelch motif BACK PF07707.13 MSTRG.11391.1_2 - 2.4e-30 104.6 0.0 4.2e-30 103.7 0.0 1.4 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_2 PF07646.13 MSTRG.11391.1_2 - 1.4e-25 88.1 8.1 0.00011 21.9 0.0 6.0 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.4 MSTRG.11391.1_2 - 1.5e-23 82.3 1.2 2e-06 27.5 0.0 6.0 6 0 0 6 6 6 4 Galactose oxidase, central domain BTB PF00651.29 MSTRG.11391.1_2 - 1.8e-17 63.4 0.1 3.7e-17 62.4 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.4 MSTRG.11391.1_2 - 7.9e-15 54.6 7.5 1e-05 25.5 0.1 6.3 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.4 MSTRG.11391.1_2 - 4e-05 23.4 0.7 1.7 8.6 0.0 4.0 3 0 0 3 3 3 2 Kelch motif PQQ_3 PF13570.4 MSTRG.11391.1_2 - 5 7.6 8.7 11 6.5 0.1 4.3 4 0 0 4 4 4 0 PQQ-like domain EGF PF00008.25 MSTRG.12256.1_3 - 3.4e-11 43.1 25.3 8.1e-07 29.1 8.2 3.3 2 1 1 3 3 3 2 EGF-like domain hEGF PF12661.5 MSTRG.12256.1_3 - 0.0001 22.7 28.6 0.0004 20.8 3.8 4.8 4 1 0 4 4 4 2 Human growth factor-like EGF EGF_2 PF07974.11 MSTRG.12256.1_3 - 0.00022 21.4 23.1 0.0041 17.3 7.4 2.9 2 0 0 2 2 2 2 EGF-like domain cEGF PF12662.5 MSTRG.12256.1_3 - 0.00092 19.0 1.4 0.00092 19.0 1.4 3.3 4 0 0 4 4 4 1 Complement Clr-like EGF-like FXa_inhibition PF14670.4 MSTRG.12256.1_3 - 0.1 12.7 24.0 0.71 10.1 3.4 2.9 2 1 0 2 2 2 0 Coagulation Factor Xa inhibitory site EGF_3 PF12947.5 MSTRG.12256.1_3 - 0.29 11.2 23.5 0.9 9.7 5.0 4.0 2 1 1 3 3 3 0 EGF domain Laminin_EGF PF00053.22 MSTRG.12256.1_3 - 4.4 7.4 23.7 1.6 8.8 6.4 2.9 2 1 1 3 3 3 0 Laminin EGF domain Collagen PF01391.16 MSTRG.13193.1_2 - 7.3e-55 182.4 361.9 2.4e-08 33.5 26.9 19.2 15 2 4 19 19 19 18 Collagen triple helix repeat (20 copies) NCBP3 PF10309.7 MSTRG.3916.1_3 - 3.2e-21 74.8 0.1 5.4e-21 74.1 0.1 1.4 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 RNA_bind PF08675.9 MSTRG.3916.1_3 - 0.011 15.7 0.0 0.025 14.5 0.0 1.6 1 0 0 1 1 1 0 RNA binding domain F-box-like PF12937.5 MSTRG.24232.2_1 - 5.5e-13 48.4 0.0 1.8e-12 46.8 0.0 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 MSTRG.24232.2_1 - 1.9e-09 37.0 0.2 6.2e-09 35.4 0.2 1.9 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.3 MSTRG.24232.2_1 - 2.1e-05 24.2 0.1 6.3e-05 22.7 0.0 1.8 2 0 0 2 2 2 1 F-box SCAB-IgPH PF16709.3 MSTRG.24232.2_1 - 0.052 13.0 0.0 0.088 12.3 0.0 1.3 1 0 0 1 1 1 0 Fused Ig-PH domain of plant-specific actin-binding protein Cas9-BH PF16593.3 MSTRG.24232.2_2 - 0.12 12.0 1.8 0.29 10.7 1.8 1.6 1 0 0 1 1 1 0 Bridge helix of CRISPR-associated endonuclease Cas9 SpoU_methylase PF00588.17 MSTRG.21181.1_2 - 8.9e-23 80.9 0.0 5.3e-22 78.4 0.0 2.0 1 1 0 1 1 1 1 SpoU rRNA Methylase family Myotub-related PF06602.12 MSTRG.8114.2_1 - 6.4e-143 475.7 0.1 9.1e-143 475.2 0.1 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.18 MSTRG.8114.2_1 - 5.8e-19 67.9 0.0 1.2e-18 66.9 0.0 1.5 1 0 0 1 1 1 1 GRAM domain 3-PAP PF12578.6 MSTRG.8114.2_1 - 0.0014 18.2 0.2 0.0031 17.1 0.2 1.5 1 0 0 1 1 1 1 Myotubularin-associated protein Y_phosphatase PF00102.25 MSTRG.8114.2_1 - 0.0091 15.5 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.18 MSTRG.8114.2_1 - 0.07 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 MSTRG.8114.2_1 - 0.082 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Radical_SAM PF04055.19 MSTRG.17660.1_3 - 6.1e-14 52.6 0.0 1e-13 51.9 0.0 1.4 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.4 MSTRG.17660.1_3 - 5.9e-09 36.2 0.2 1.2e-08 35.2 0.2 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.4 MSTRG.17660.1_3 - 4.7e-08 33.1 0.4 2.6e-07 30.7 0.1 2.0 2 0 0 2 2 2 1 4Fe-4S single cluster domain Lectin_C PF00059.19 MSTRG.20186.1_2 - 6.3e-18 65.4 0.0 8.5e-18 64.9 0.0 1.2 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.10 MSTRG.20186.1_2 - 0.0012 18.4 0.1 0.0019 17.7 0.1 1.5 1 1 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Vps35 PF03635.15 MSTRG.21523.1_3 - 6.8e-301 1000.0 11.5 7.9e-301 999.8 11.5 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 FerA PF08165.9 MSTRG.21523.1_3 - 0.089 12.6 0.1 0.38 10.6 0.1 2.1 1 0 0 1 1 1 0 FerA (NUC095) domain GTP_EFTU PF00009.25 MSTRG.23394.2_1 - 1.9e-46 157.9 0.0 3.1e-46 157.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.15 MSTRG.23394.2_1 - 4.7e-25 87.9 0.0 1e-24 86.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain HBS1_N PF08938.8 MSTRG.23394.2_1 - 3.2e-16 59.3 0.1 6.3e-16 58.3 0.1 1.5 1 0 0 1 1 1 1 HBS1 N-terminus GTP_EFTU_D2 PF03144.23 MSTRG.23394.2_1 - 1.9e-06 28.0 0.0 3.7e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 MSTRG.23394.2_1 - 1.6e-05 24.8 0.1 0.00047 20.1 0.1 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.4 MSTRG.23394.2_1 - 0.0054 16.9 0.0 0.011 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain GTP_EFTU_D4 PF14578.4 MSTRG.23394.2_1 - 0.08 12.8 0.0 0.37 10.7 0.0 2.0 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Toxin_15 PF07906.11 MSTRG.23394.2_1 - 0.13 11.7 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 ShET2 enterotoxin, N-terminal region Ribosomal_S11 PF00411.17 MSTRG.5395.1_3 - 2.7e-31 108.1 0.9 4e-31 107.5 0.9 1.2 1 0 0 1 1 1 1 Ribosomal protein S11 T4_deiodinase PF00837.15 MSTRG.23965.1_3 - 1.4e-72 243.7 0.0 1.8e-72 243.3 0.0 1.1 1 0 0 1 1 1 1 Iodothyronine deiodinase Lys PF00062.18 MSTRG.19363.1_1 - 0.00073 19.6 2.5 0.0062 16.6 0.6 2.3 2 0 0 2 2 2 1 C-type lysozyme/alpha-lactalbumin family Myc_N PF01056.16 MSTRG.19363.1_1 - 0.016 15.0 5.2 0.024 14.4 5.2 1.2 1 0 0 1 1 1 0 Myc amino-terminal region CDC45 PF02724.12 MSTRG.19363.1_1 - 5.9 4.9 12.7 4.9 5.2 10.0 1.8 1 1 1 2 2 2 0 CDC45-like protein START PF01852.17 MSTRG.5695.2_3 - 1.8e-33 115.6 0.4 2.6e-33 115.1 0.4 1.2 1 0 0 1 1 1 1 START domain Ion_trans PF00520.29 MSTRG.13994.1_3 - 9.8e-51 172.2 7.3 1.4e-50 171.7 7.3 1.2 1 0 0 1 1 1 1 Ion transport protein Kv2channel PF03521.12 MSTRG.13994.1_3 - 2.2e-18 66.5 15.9 3.2e-16 59.4 14.7 3.2 1 1 1 2 2 2 1 Kv2 voltage-gated K+ channel Ion_trans_2 PF07885.14 MSTRG.13994.1_3 - 2.7e-12 46.3 2.7 2.7e-12 46.3 2.7 2.3 2 0 0 2 2 2 1 Ion channel RRM_1 PF00076.20 MSTRG.21161.3_1 - 2.2e-14 52.9 0.0 3.7e-07 29.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 MSTRG.21161.3_1 - 2.1e-05 24.0 0.1 0.0003 20.3 0.0 2.1 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 MSTRG.21161.3_1 - 0.00028 20.5 0.0 0.093 12.5 0.0 2.3 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_3 PF08777.9 MSTRG.21161.3_1 - 0.063 13.2 0.0 0.4 10.6 0.0 2.0 2 0 0 2 2 2 0 RNA binding motif RRM_5 PF13893.4 MSTRG.21161.3_2 - 6.1e-51 171.1 0.0 1e-50 170.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.20 MSTRG.21161.3_2 - 0.00057 19.5 0.0 0.049 13.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRE1 PF08647.9 MSTRG.8280.1_1 - 0.012 15.6 5.6 0.026 14.4 5.6 1.6 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase DUF3584 PF12128.6 MSTRG.8280.1_1 - 0.048 11.0 5.2 0.061 10.7 5.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ATG16 PF08614.9 MSTRG.8280.1_1 - 0.057 13.5 7.1 0.057 13.5 5.3 1.6 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) HAUS-augmin3 PF14932.4 MSTRG.8280.1_1 - 0.1 12.0 5.2 0.15 11.5 5.2 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 MitMem_reg PF13012.4 MSTRG.8280.1_1 - 0.12 12.7 3.4 0.24 11.7 3.4 1.5 1 0 0 1 1 1 0 Maintenance of mitochondrial structure and function APG6 PF04111.10 MSTRG.8280.1_1 - 0.17 11.1 6.7 0.25 10.6 6.7 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF342 PF03961.11 MSTRG.8280.1_1 - 0.26 9.7 4.2 0.33 9.4 4.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Baculo_PEP_C PF04513.10 MSTRG.8280.1_1 - 0.26 11.2 4.5 0.49 10.3 4.5 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Uso1_p115_C PF04871.11 MSTRG.8280.1_1 - 0.27 11.5 5.4 0.63 10.3 5.4 1.6 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF1664 PF07889.10 MSTRG.8280.1_1 - 0.27 11.1 1.8 0.52 10.2 1.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF972 PF06156.11 MSTRG.8280.1_1 - 0.3 11.6 7.6 0.72 10.4 7.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF972) Myosin_tail_1 PF01576.17 MSTRG.8280.1_1 - 0.31 8.6 6.5 0.4 8.3 6.5 1.1 1 0 0 1 1 1 0 Myosin tail CALCOCO1 PF07888.9 MSTRG.8280.1_1 - 0.35 9.3 6.2 0.43 8.9 6.2 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Tropomyosin PF00261.18 MSTRG.8280.1_1 - 0.42 9.8 7.3 0.58 9.3 7.3 1.2 1 0 0 1 1 1 0 Tropomyosin DUF724 PF05266.12 MSTRG.8280.1_1 - 0.57 9.8 5.7 1 9.1 5.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Fez1 PF06818.13 MSTRG.8280.1_1 - 0.59 10.4 11.4 0.18 12.1 8.1 1.7 2 0 0 2 2 2 0 Fez1 CLZ PF16526.3 MSTRG.8280.1_1 - 0.85 9.9 4.6 1.7 8.9 4.6 1.5 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF3450 PF11932.6 MSTRG.8280.1_1 - 1.1 8.3 7.6 1.6 7.8 7.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) IncA PF04156.12 MSTRG.8280.1_1 - 1.5 8.4 6.5 2.3 7.8 6.5 1.3 1 0 0 1 1 1 0 IncA protein Mod_r PF07200.11 MSTRG.8280.1_1 - 4.7 7.2 11.5 10 6.1 11.5 1.5 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein DivIC PF04977.13 MSTRG.8280.1_1 - 4.8 6.9 7.6 8 6.2 0.9 2.5 1 1 1 2 2 2 0 Septum formation initiator Rod_C PF10493.7 MSTRG.16855.1_1 - 9.4e-203 674.4 1.4 9.4e-203 674.4 1.4 1.7 2 0 0 2 2 2 1 Rough deal protein C-terminal region Ets PF00178.20 MSTRG.20582.1_3 - 1.6e-34 118.1 2.6 2.6e-34 117.4 2.6 1.3 1 0 0 1 1 1 1 Ets-domain Ndc80_HEC PF03801.11 MSTRG.5736.2_2 - 1.7e-44 151.0 1.3 3.2e-44 150.1 0.0 2.2 2 0 0 2 2 2 1 HEC/Ndc80p family DUF1515 PF07439.9 MSTRG.5736.2_2 - 0.0092 15.8 1.3 0.0092 15.8 1.3 2.9 2 1 0 2 2 2 1 Protein of unknown function (DUF1515) DUF3584 PF12128.6 MSTRG.5736.2_2 - 1.3 6.3 47.3 0.45 7.8 22.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) DUF1232 PF06803.10 MSTRG.14981.2_2 - 6.9e-09 35.2 7.6 1.2e-08 34.4 7.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1232) zf-C3HC4 PF00097.23 MSTRG.14981.2_2 - 1.2e-08 34.5 3.4 2.6e-08 33.4 3.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 MSTRG.14981.2_2 - 9.5e-08 31.6 3.4 1.9e-07 30.7 3.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.14981.2_2 - 1.6e-07 31.1 5.0 3.3e-07 30.1 2.5 2.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 MSTRG.14981.2_2 - 1.1e-06 28.6 6.1 3e-06 27.1 6.1 1.9 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 MSTRG.14981.2_2 - 6.3e-06 25.8 4.4 1.9e-05 24.3 4.4 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.14981.2_2 - 7.4e-06 26.0 6.1 1.6e-05 24.9 6.1 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.4 MSTRG.14981.2_2 - 5.1e-05 23.0 3.9 0.00013 21.8 3.9 1.7 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.4 MSTRG.14981.2_2 - 0.0005 19.7 4.2 0.0021 17.8 4.2 2.0 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.5 MSTRG.14981.2_2 - 0.49 10.6 3.6 1.4 9.1 3.6 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain Globin PF00042.20 MSTRG.5250.1_3 - 7.2e-24 84.3 0.0 1.2e-23 83.6 0.0 1.4 1 0 0 1 1 1 1 Globin DAO PF01266.22 MSTRG.20408.1_3 - 6.7e-46 157.3 0.0 1e-45 156.7 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.3 MSTRG.20408.1_3 - 2.3e-40 137.2 0.0 4.3e-40 136.3 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase EF-hand_7 PF13499.4 MSTRG.20408.1_3 - 2.5e-09 37.4 0.4 6.1e-09 36.1 0.4 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 MSTRG.20408.1_3 - 2.9e-09 35.7 0.3 1.9e-05 23.7 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 MSTRG.20408.1_3 - 4.5e-08 32.3 0.4 0.018 14.8 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain FAD_binding_2 PF00890.22 MSTRG.20408.1_3 - 1.8e-06 27.2 0.1 0.00095 18.2 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.12 MSTRG.20408.1_3 - 3.4e-05 23.1 5.9 0.0026 16.9 0.2 3.9 2 1 2 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.5 MSTRG.20408.1_3 - 8e-05 22.0 0.1 0.00019 20.8 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.20 MSTRG.20408.1_3 - 0.00069 18.7 0.1 0.12 11.3 0.0 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A EF-hand_8 PF13833.4 MSTRG.20408.1_3 - 0.00074 19.1 0.1 0.0019 17.8 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.20408.1_3 - 0.0076 15.6 0.6 0.042 13.2 0.1 2.2 2 0 0 2 2 2 1 EF hand EF-hand_4 PF12763.5 MSTRG.20408.1_3 - 0.014 15.2 0.8 0.03 14.1 0.8 1.5 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand HI0933_like PF03486.12 MSTRG.20408.1_3 - 0.015 13.8 0.1 0.025 13.1 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_3 PF13738.4 MSTRG.20408.1_3 - 0.017 14.3 0.0 0.14 11.3 0.0 2.3 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase EF-hand_9 PF14658.4 MSTRG.20408.1_3 - 0.14 12.4 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain SPARC_Ca_bdg PF10591.7 MSTRG.20408.1_3 - 0.14 12.3 0.7 0.32 11.2 0.7 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Pyr_redox PF00070.25 MSTRG.20408.1_3 - 0.47 10.9 1.9 3.1 8.3 0.1 3.0 4 0 0 4 4 4 0 Pyridine nucleotide-disulphide oxidoreductase DUF737 PF05300.9 MSTRG.15347.1_2 - 7.3e-54 183.0 30.0 5.3e-53 180.2 30.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF737) CHCH PF06747.11 MSTRG.15347.1_2 - 0.01 15.8 0.6 0.017 15.1 0.6 1.4 1 0 0 1 1 1 0 CHCH domain DUF3292 PF11696.6 MSTRG.15347.1_2 - 0.14 10.3 6.3 0.21 9.8 6.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) ECH_2 PF16113.3 MSTRG.15347.1_2 - 0.21 10.9 6.4 0.32 10.3 6.4 1.3 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase DUF1690 PF07956.9 MSTRG.15347.1_2 - 0.21 11.9 17.6 0.035 14.4 6.2 2.3 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) ORF6N PF10543.7 MSTRG.15347.1_2 - 1.6 8.8 6.5 5.1 7.2 0.4 2.7 2 1 0 2 2 2 0 ORF6N domain bZIP_1 PF00170.19 MSTRG.15347.1_2 - 4.1 7.5 18.0 0.1 12.6 8.1 2.6 2 0 0 2 2 2 0 bZIP transcription factor MENTAL PF10457.7 MSTRG.10468.1_2 - 1.1e-62 210.8 1.4 1.8e-62 210.2 1.4 1.3 1 0 0 1 1 1 1 Cholesterol-capturing domain YjgP_YjgQ PF03739.12 MSTRG.10468.1_2 - 4.3 6.0 5.7 6.8 5.3 5.7 1.2 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family ANAPC4_WD40 PF12894.5 MSTRG.8058.1_2 - 1.8e-25 88.9 1.1 0.00031 20.8 0.0 6.6 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 MSTRG.8058.1_2 - 2.7e-24 84.8 16.2 3e-05 24.6 0.4 6.9 6 1 0 7 7 7 4 WD domain, G-beta repeat eIF2A PF08662.9 MSTRG.8058.1_2 - 2e-11 44.0 2.0 2.1e-06 27.6 1.5 3.2 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.10 MSTRG.8058.1_2 - 1.3e-07 31.2 0.0 0.004 16.9 0.0 4.3 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.12 MSTRG.8058.1_2 - 1.1e-05 24.6 0.9 0.0044 16.0 0.8 2.7 1 1 1 3 3 3 2 Coatomer WD associated region Peptidase_S9_N PF02897.13 MSTRG.8058.1_2 - 3.5e-05 22.7 4.3 0.039 12.6 0.0 2.7 2 1 1 3 3 3 2 Prolyl oligopeptidase, N-terminal beta-propeller domain DUF4613 PF15390.4 MSTRG.8058.1_2 - 0.0021 16.4 2.0 0.0047 15.2 2.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4613) Cytochrom_D1 PF02239.14 MSTRG.8058.1_2 - 0.0068 14.8 0.0 0.22 9.9 0.0 2.1 1 1 1 2 2 2 2 Cytochrome D1 heme domain RAB3GAP2_N PF14655.4 MSTRG.8058.1_2 - 0.0094 15.1 0.0 3.5 6.6 0.0 2.7 3 0 0 3 3 3 2 Rab3 GTPase-activating protein regulatory subunit N-terminus Nup160 PF11715.6 MSTRG.8058.1_2 - 0.013 14.0 0.2 0.036 12.6 0.1 1.7 2 0 0 2 2 2 0 Nucleoporin Nup120/160 PQQ_2 PF13360.4 MSTRG.8058.1_2 - 0.016 14.7 0.1 1.6 8.1 0.0 2.3 2 0 0 2 2 2 0 PQQ-like domain DPPIV_N PF00930.19 MSTRG.8058.1_2 - 0.024 13.3 0.1 0.24 10.0 0.0 2.4 2 0 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region IKI3 PF04762.10 MSTRG.8058.1_2 - 0.03 12.2 0.1 0.23 9.3 0.0 2.0 1 1 1 2 2 2 0 IKI3 family Me-amine-dh_H PF06433.9 MSTRG.8058.1_2 - 0.07 11.9 0.0 2.1 7.0 0.0 2.3 2 0 0 2 2 2 0 Methylamine dehydrogenase heavy chain (MADH) Tropomyosin PF00261.18 MSTRG.24844.5_2 - 3.8e-92 307.8 58.9 3.8e-92 307.8 58.9 2.0 1 1 1 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.5 MSTRG.24844.5_2 - 8.2e-38 129.6 70.6 4.2e-34 117.6 39.7 2.9 1 1 1 2 2 2 2 Tropomyosin like CLZ PF16526.3 MSTRG.24844.5_2 - 7.2e-10 39.0 45.4 1.4e-06 28.4 10.7 4.7 2 2 2 4 4 4 4 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Laminin_II PF06009.10 MSTRG.24844.5_2 - 3.1e-06 27.1 33.8 0.00087 19.2 8.2 3.5 1 1 4 5 5 5 2 Laminin Domain II XhlA PF10779.7 MSTRG.24844.5_2 - 0.0019 18.2 49.4 0.023 14.7 3.2 5.9 2 1 4 6 6 6 4 Haemolysin XhlA ATG16 PF08614.9 MSTRG.24844.5_2 - 0.016 15.3 19.5 0.016 15.3 19.5 3.5 1 1 1 2 2 1 0 Autophagy protein 16 (ATG16) BST2 PF16716.3 MSTRG.24844.5_2 - 0.018 15.5 7.2 0.018 15.5 7.2 4.9 1 1 5 6 6 6 0 Bone marrow stromal antigen 2 IncA PF04156.12 MSTRG.24844.5_2 - 0.047 13.3 55.9 0.067 12.8 23.9 2.7 1 1 2 3 3 3 0 IncA protein TMF_DNA_bd PF12329.6 MSTRG.24844.5_2 - 0.056 13.3 1.0 0.053 13.4 12.2 6.3 1 1 4 6 6 6 0 TATA element modulatory factor 1 DNA binding ADIP PF11559.6 MSTRG.24844.5_2 - 0.099 12.6 47.7 0.25 11.3 6.3 4.2 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding Reo_sigmaC PF04582.10 MSTRG.24844.5_2 - 0.11 11.8 10.4 0.06 12.6 2.2 2.2 1 1 0 2 2 2 0 Reovirus sigma C capsid protein FbpA PF05833.9 MSTRG.24844.5_2 - 0.12 11.0 32.3 0.17 10.5 32.3 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) CENP-F_leu_zip PF10473.7 MSTRG.24844.5_2 - 0.12 12.2 63.9 0.38 10.6 31.0 2.5 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Lebercilin PF15619.4 MSTRG.24844.5_2 - 0.52 9.8 63.0 6.4 6.2 29.3 3.2 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease MscS_porin PF12795.5 MSTRG.24844.5_2 - 0.55 9.6 44.5 3 7.2 9.3 3.1 1 1 2 3 3 3 0 Mechanosensitive ion channel porin domain APG6 PF04111.10 MSTRG.24844.5_2 - 0.66 9.2 60.1 0.3 10.3 13.5 3.2 1 1 3 4 4 4 0 Autophagy protein Apg6 Golgin_A5 PF09787.7 MSTRG.24844.5_2 - 0.85 8.9 52.3 1.6 8.0 23.4 2.3 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF745 PF05335.11 MSTRG.24844.5_2 - 1.1 8.9 46.3 0.53 9.9 15.2 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF745) LOH1CR12 PF10158.7 MSTRG.24844.5_2 - 1.2 9.1 9.9 0.61 10.0 0.7 2.9 2 1 1 3 3 3 0 Tumour suppressor protein DUF1664 PF07889.10 MSTRG.24844.5_2 - 1.3 8.9 31.1 0.085 12.7 3.2 3.9 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) DUF3450 PF11932.6 MSTRG.24844.5_2 - 1.4 8.0 48.8 0.018 14.2 6.5 4.0 1 1 2 3 3 2 0 Protein of unknown function (DUF3450) AAA_13 PF13166.4 MSTRG.24844.5_2 - 1.8 7.0 44.2 2.3 6.7 11.7 2.2 1 1 1 2 2 2 0 AAA domain ERM PF00769.17 MSTRG.24844.5_2 - 2.2 7.9 69.8 2.6 7.7 18.6 3.0 1 1 2 3 3 3 0 Ezrin/radixin/moesin family MAD PF05557.11 MSTRG.24844.5_2 - 4.8 5.3 56.7 8.6 4.4 26.8 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein Laminin_I PF06008.12 MSTRG.24844.5_2 - 5.9 6.4 52.6 1.5 8.3 15.3 3.1 1 1 2 3 3 3 0 Laminin Domain I Exonuc_VII_L PF02601.13 MSTRG.24844.5_2 - 6.8 6.0 34.8 18 4.6 13.3 2.3 1 1 1 2 2 2 0 Exonuclease VII, large subunit Alanine_zipper PF11839.6 MSTRG.24844.5_2 - 9.9 6.4 43.4 2.5 8.3 2.3 4.7 1 1 3 4 4 4 0 Alanine-zipper, major outer membrane lipoprotein DUF3548 PF12068.6 MSTRG.19450.1_2 - 8.7e-53 178.6 0.0 1.2e-52 178.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3548) RabGAP-TBC PF00566.16 MSTRG.19450.1_2 - 2e-49 168.0 5.6 2.8e-49 167.6 5.6 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF2203 PF09969.7 MSTRG.19450.1_2 - 0.16 12.6 0.1 0.35 11.5 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) C2-set_2 PF08205.10 MSTRG.17806.1_1 - 8e-19 67.4 1.2 6e-16 58.2 0.3 3.3 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 MSTRG.17806.1_1 - 4.3e-16 59.2 3.2 1.1e-07 32.2 0.1 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.17806.1_1 - 8.9e-12 45.1 5.4 8.7e-06 25.9 0.1 4.2 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 MSTRG.17806.1_1 - 1.6e-11 44.2 0.6 6.9e-09 35.7 0.0 3.0 3 1 0 3 3 3 2 Immunoglobulin V-set domain ig PF00047.23 MSTRG.17806.1_1 - 4.3e-10 39.5 0.7 0.00051 20.0 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 MSTRG.17806.1_1 - 1e-07 31.8 0.2 0.046 13.7 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin I-set domain SKG6 PF08693.8 MSTRG.17806.1_1 - 0.0018 17.5 0.9 0.004 16.4 0.9 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Kelch_3 PF13415.4 MSTRG.13131.1_3 - 9.2e-30 102.2 5.7 6.1e-07 29.4 0.0 7.0 7 1 0 7 7 7 4 Galactose oxidase, central domain Kelch_4 PF13418.4 MSTRG.13131.1_3 - 2.5e-27 94.4 7.7 9.3e-06 25.4 0.0 6.5 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.4 MSTRG.13131.1_3 - 2.2e-21 75.2 1.4 2.4e-05 24.3 0.0 5.6 4 1 1 5 5 5 3 Kelch motif Kelch_5 PF13854.4 MSTRG.13131.1_3 - 8.5e-20 70.2 7.5 5.2e-07 29.4 0.0 6.9 6 1 0 6 6 6 5 Kelch motif Kelch_2 PF07646.13 MSTRG.13131.1_3 - 7.4e-19 66.8 1.5 0.00022 20.9 0.0 5.3 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.23 MSTRG.13131.1_3 - 1.1e-15 56.8 0.1 0.0002 20.7 0.0 5.1 5 0 0 5 5 5 3 Kelch motif NAD_binding_6 PF08030.10 MSTRG.15909.1_1 - 4.3e-30 104.8 2.0 5.7e-30 104.4 0.0 2.1 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.17 MSTRG.15909.1_1 - 2.3e-25 89.0 4.8 2.3e-25 89.0 4.8 3.4 5 0 0 5 5 5 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.10 MSTRG.15909.1_1 - 4.9e-22 77.9 0.0 1.2e-21 76.7 0.0 1.7 1 0 0 1 1 1 1 FAD-binding domain FAD_binding_6 PF00970.22 MSTRG.15909.1_1 - 0.00099 19.3 0.0 0.0021 18.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.19 MSTRG.15909.1_1 - 0.071 13.6 0.8 0.26 11.8 0.0 2.3 2 1 0 2 2 2 0 Oxidoreductase NAD-binding domain Ig_3 PF13927.4 MSTRG.10071.1_3 - 4.6e-30 103.9 0.9 7.7e-13 48.7 0.0 3.6 4 0 0 4 4 4 3 Immunoglobulin domain I-set PF07679.14 MSTRG.10071.1_3 - 1.3e-21 76.3 0.1 4.9e-08 32.8 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.10071.1_3 - 1.6e-21 76.3 0.0 2.3e-06 27.7 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 MSTRG.10071.1_3 - 2.1e-18 66.2 0.0 2.8e-05 24.1 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.10 MSTRG.10071.1_3 - 1.2e-15 57.2 0.0 1.7e-12 47.1 0.0 2.6 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain V-set PF07686.15 MSTRG.10071.1_3 - 4.4e-15 55.7 0.5 2.4e-06 27.5 0.0 4.1 3 1 1 4 4 4 3 Immunoglobulin V-set domain Syndecan PF01034.18 MSTRG.10071.1_3 - 0.46 10.3 0.0 0.46 10.3 0.0 2.2 2 0 0 2 2 2 0 Syndecan domain AAA_14 PF13173.4 MSTRG.11294.1_1 - 1.3e-07 31.5 0.0 3e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA PF00004.27 MSTRG.11294.1_1 - 5.2e-06 26.8 0.7 1.7e-05 25.1 0.0 2.3 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 MSTRG.11294.1_1 - 9.2e-05 22.7 0.0 0.018 15.3 0.1 2.7 1 1 1 2 2 2 1 AAA ATPase domain PhoH PF02562.14 MSTRG.11294.1_1 - 0.00084 18.7 0.0 0.0017 17.7 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein AAA_19 PF13245.4 MSTRG.11294.1_1 - 0.00084 19.6 0.0 0.0028 17.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.4 MSTRG.11294.1_1 - 0.00091 18.7 0.0 0.003 17.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.4 MSTRG.11294.1_1 - 0.0017 18.5 0.3 0.024 14.8 0.1 2.7 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.4 MSTRG.11294.1_1 - 0.0026 18.1 0.0 0.0098 16.3 0.0 2.0 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.15 MSTRG.11294.1_1 - 0.0047 16.6 0.0 0.0091 15.7 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein SlyX PF04102.10 MSTRG.11294.1_1 - 0.0072 16.8 1.0 0.0072 16.8 1.0 4.0 3 1 1 4 4 4 1 SlyX AAA_5 PF07728.12 MSTRG.11294.1_1 - 0.0097 15.8 0.0 0.023 14.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.4 MSTRG.11294.1_1 - 0.015 15.4 0.5 0.029 14.5 0.0 1.7 2 0 0 2 2 1 0 AAA domain ResIII PF04851.13 MSTRG.11294.1_1 - 0.017 15.0 0.2 1.8 8.4 0.0 3.3 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit Lon_2 PF13337.4 MSTRG.11294.1_1 - 0.021 13.3 0.1 0.13 10.7 0.0 1.9 2 0 0 2 2 2 0 Putative ATP-dependent Lon protease DUF4407 PF14362.4 MSTRG.11294.1_1 - 0.032 13.4 12.4 0.019 14.2 7.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) RNA_helicase PF00910.20 MSTRG.11294.1_1 - 0.04 14.2 0.0 0.12 12.6 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.4 MSTRG.11294.1_1 - 0.055 13.1 0.0 0.096 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATPase PF06745.11 MSTRG.11294.1_1 - 0.16 11.1 0.1 4.2 6.5 0.0 2.8 3 0 0 3 3 3 0 KaiC IncA PF04156.12 MSTRG.11294.1_1 - 7.6 6.1 23.3 8.7 6.0 11.0 2.4 2 0 0 2 2 2 0 IncA protein CENP-F_leu_zip PF10473.7 MSTRG.11294.1_1 - 7.8 6.4 20.9 1.2 9.0 6.3 2.5 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AKAP7_NLS PF10469.7 MSTRG.9634.2_2 - 4.8e-43 147.3 0.0 6.8e-43 146.8 0.0 1.2 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain AKAP7_RIRII_bdg PF10470.7 MSTRG.9634.2_2 - 1.8e-13 50.2 0.5 1.8e-13 50.2 0.5 2.5 2 0 0 2 2 2 1 PKA-RI-RII subunit binding domain of A-kinase anchor protein 2_5_RNA_ligase2 PF13563.4 MSTRG.9634.2_2 - 3e-06 27.1 0.0 5.1e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.14 MSTRG.9634.2_2 - 0.17 12.0 0.3 1.9 8.6 0.1 2.2 2 0 0 2 2 2 0 LigT like Phosphoesterase Tim54 PF11711.6 MSTRG.9634.2_2 - 0.19 10.4 3.1 0.29 9.7 3.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 PGA2 PF07543.10 MSTRG.9634.2_2 - 8.4 6.2 9.4 15 5.4 9.4 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 DUF1943 PF09172.9 MSTRG.8360.1_1 - 4.1e-62 210.1 5.5 4.1e-62 210.1 5.5 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF1943) DUF1081 PF06448.9 MSTRG.8360.1_1 - 1.2e-32 112.5 0.4 1.2e-31 109.3 0.0 3.2 3 0 0 3 3 3 1 Domain of Unknown Function (DUF1081) F_actin_bind PF08919.8 MSTRG.8360.1_1 - 0.25 11.3 4.6 7.8 6.5 0.1 4.2 4 1 1 5 5 5 0 F-actin binding UPF0147 PF03685.11 MSTRG.8360.1_1 - 1.2 9.0 6.6 22 5.1 0.2 4.7 4 1 1 5 5 5 0 Uncharacterised protein family (UPF0147) Nuc_sug_transp PF04142.13 MSTRG.26760.1_1 - 2.5e-127 424.3 24.9 3e-127 424.0 24.9 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.18 MSTRG.26760.1_1 - 5.1e-06 26.6 36.6 7.2e-05 22.8 12.0 2.7 2 1 0 2 2 2 2 EamA-like transporter family EmrE PF13536.4 MSTRG.26760.1_1 - 9.9e-05 21.9 3.7 9.9e-05 21.9 3.7 1.9 2 1 0 2 2 2 1 Putative multidrug resistance efflux transporter PUNUT PF16913.3 MSTRG.26760.1_1 - 0.0005 19.2 23.0 0.0029 16.7 23.0 2.0 1 1 0 1 1 1 1 Purine nucleobase transmembrane transport CRT-like PF08627.8 MSTRG.26760.1_1 - 0.00069 18.5 3.9 0.00069 18.5 3.9 2.3 1 1 1 2 2 2 1 CRT-like, chloroquine-resistance transporter-like UAA PF08449.9 MSTRG.26760.1_1 - 0.0043 16.2 11.2 0.0043 16.2 11.2 2.7 2 1 0 2 2 2 1 UAA transporter family DUF202 PF02656.13 MSTRG.26760.1_1 - 0.049 13.9 0.1 0.049 13.9 0.1 3.7 2 1 2 4 4 4 0 Domain of unknown function (DUF202) TPT PF03151.14 MSTRG.26760.1_1 - 0.81 8.8 15.3 7.7 5.6 15.3 2.3 1 1 0 1 1 1 0 Triose-phosphate Transporter family YdjO PF14169.4 MSTRG.28363.1_2 - 0.38 10.4 1.4 1.2 8.8 0.2 2.0 2 0 0 2 2 2 0 Cold-inducible protein YdjO 7tm_1 PF00001.19 MSTRG.15642.2_1 - 3.9e-07 29.4 9.2 6.5e-05 22.2 6.3 2.5 2 1 0 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.19 MSTRG.15642.2_3 - 6e-24 84.6 7.0 8.6e-24 84.1 7.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3 PF11710.6 MSTRG.15642.2_3 - 0.032 13.9 4.7 0.049 13.3 4.7 1.2 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 RWD PF05773.20 MSTRG.25889.3_2 - 3.2e-15 56.3 0.1 6.7e-15 55.3 0.1 1.6 1 0 0 1 1 1 1 RWD domain PAS_3 PF08447.10 MSTRG.14287.1_3 - 1.3e-20 73.4 0.0 1.5e-14 53.9 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS PF00989.23 MSTRG.14287.1_3 - 1.4e-20 73.3 0.0 3.5e-14 52.6 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 MSTRG.14287.1_3 - 2.3e-19 69.5 0.3 6.9e-16 58.2 0.2 2.4 2 0 0 2 2 2 2 PAS domain HLH PF00010.24 MSTRG.14287.1_3 - 2.3e-14 52.9 1.1 4.3e-14 52.1 1.1 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.5 MSTRG.14287.1_3 - 1e-07 32.0 0.0 0.00026 21.1 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.8 MSTRG.14287.1_3 - 0.0017 18.5 0.0 1.1 9.4 0.0 2.4 2 0 0 2 2 2 2 PAS fold COMM_domain PF07258.12 MSTRG.11018.1_2 - 3.2e-16 59.1 0.4 5.9e-16 58.2 0.4 1.5 1 0 0 1 1 1 1 COMM domain PORR PF11955.6 MSTRG.11018.1_2 - 0.033 13.0 0.0 0.041 12.7 0.0 1.1 1 0 0 1 1 1 0 Plant organelle RNA recognition domain DUF4429 PF14472.4 MSTRG.11018.1_2 - 0.074 13.5 0.2 0.13 12.7 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4429) Methyltransf_25 PF13649.4 MSTRG.15827.8_2 - 1.6e-21 76.7 0.4 2.8e-19 69.5 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.10 MSTRG.15827.8_2 - 1.9e-20 73.1 0.3 5.5e-19 68.5 0.0 2.7 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.4 MSTRG.15827.8_2 - 4.6e-16 58.8 0.2 2e-13 50.3 0.0 2.8 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.4 MSTRG.15827.8_2 - 9e-14 51.6 0.5 1.1e-10 41.6 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_PK PF05891.10 MSTRG.15827.8_2 - 5.5e-12 45.5 0.0 1.5e-11 44.1 0.0 1.7 2 0 0 2 2 2 1 AdoMet dependent proline di-methyltransferase Methyltransf_12 PF08242.10 MSTRG.15827.8_2 - 2.2e-11 44.2 2.2 1.6e-10 41.4 0.0 2.7 3 0 0 3 3 3 1 Methyltransferase domain RrnaAD PF00398.18 MSTRG.15827.8_2 - 4e-11 42.3 0.0 3.4e-08 32.8 0.0 2.3 2 1 0 2 2 2 2 Ribosomal RNA adenine dimethylase TehB PF03848.12 MSTRG.15827.8_2 - 8.5e-11 41.5 0.0 1.3e-07 31.1 0.0 2.3 2 1 0 2 2 2 2 Tellurite resistance protein TehB NodS PF05401.9 MSTRG.15827.8_2 - 4.4e-10 39.4 0.0 1e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 Nodulation protein S (NodS) Ubie_methyltran PF01209.16 MSTRG.15827.8_2 - 8.1e-09 35.0 0.0 5.4e-07 29.0 0.0 2.2 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family MTS PF05175.12 MSTRG.15827.8_2 - 2.3e-07 30.4 0.0 0.00071 19.0 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase small domain CMAS PF02353.18 MSTRG.15827.8_2 - 2.7e-07 30.0 0.2 0.0022 17.2 0.0 2.1 2 0 0 2 2 2 2 Mycolic acid cyclopropane synthetase PCMT PF01135.17 MSTRG.15827.8_2 - 8.2e-07 28.8 0.0 0.01 15.5 0.0 2.3 2 0 0 2 2 2 2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CheR PF01739.16 MSTRG.15827.8_2 - 1.6e-05 24.4 0.0 7.5e-05 22.2 0.0 2.0 2 0 0 2 2 2 1 CheR methyltransferase, SAM binding domain FtsJ PF01728.17 MSTRG.15827.8_2 - 0.001 19.1 0.0 0.019 15.0 0.0 2.2 2 0 0 2 2 2 1 FtsJ-like methyltransferase PrmA PF06325.11 MSTRG.15827.8_2 - 0.0019 17.5 0.0 2.2 7.5 0.0 2.3 2 0 0 2 2 2 2 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_2 PF00891.16 MSTRG.15827.8_2 - 0.0094 15.0 0.1 0.055 12.5 0.0 2.0 2 0 0 2 2 2 1 O-methyltransferase MetW PF07021.10 MSTRG.15827.8_2 - 0.025 14.0 0.1 7.5 6.0 0.1 2.2 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW Bin3 PF06859.10 MSTRG.15827.8_2 - 0.11 13.0 2.0 0.49 10.9 0.4 2.6 2 1 1 3 3 2 0 Bicoid-interacting protein 3 (Bin3) Aa_trans PF01490.16 MSTRG.14191.6_3 - 1.6e-91 307.0 38.5 4.1e-91 305.6 38.5 1.7 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein DDE_Tnp_Tn3 PF01526.15 MSTRG.6886.1_1 - 0.11 11.1 1.9 0.2 10.3 1.9 1.3 1 0 0 1 1 1 0 Tn3 transposase DDE domain Presenilin PF01080.15 MSTRG.6886.1_1 - 2 6.9 5.6 3.2 6.3 5.6 1.3 1 0 0 1 1 1 0 Presenilin KH_1 PF00013.27 MSTRG.5751.1_3 - 2.8e-41 139.0 10.1 5.3e-19 67.7 1.7 3.3 3 0 0 3 3 3 3 KH domain ROKNT PF08067.9 MSTRG.5751.1_3 - 3.5e-15 55.8 3.6 6.3e-15 55.0 3.6 1.4 1 0 0 1 1 1 1 ROKNT (NUC014) domain KH_2 PF07650.15 MSTRG.5751.1_3 - 1.6e-13 50.2 6.0 0.00092 18.9 0.1 3.3 2 1 1 3 3 3 3 KH domain KH_4 PF13083.4 MSTRG.5751.1_3 - 1.3e-08 34.4 2.5 6.5e-05 22.6 0.0 3.3 3 0 0 3 3 3 2 KH domain KH_5 PF13184.4 MSTRG.5751.1_3 - 2.6e-05 24.1 3.1 0.87 9.6 0.3 3.4 3 0 0 3 3 3 2 NusA-like KH domain DJ-1_PfpI PF01965.22 MSTRG.5751.1_3 - 0.033 13.8 0.1 0.074 12.7 0.0 1.5 2 0 0 2 2 2 0 DJ-1/PfpI family Ndr PF03096.12 MSTRG.23251.4_2 - 1.5e-113 378.1 0.0 1.9e-113 377.8 0.0 1.1 1 0 0 1 1 1 1 Ndr family Abhydrolase_1 PF00561.18 MSTRG.23251.4_2 - 0.0027 17.2 0.0 0.089 12.3 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 MSTRG.23251.4_2 - 0.0035 16.5 0.0 0.0056 15.8 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Wbp11 PF09429.8 MSTRG.7993.2_2 - 1.2e-22 79.9 11.7 1.2e-22 79.9 11.7 1.9 2 0 0 2 2 2 1 WW domain binding protein 11 DUF1676 PF07898.11 MSTRG.7993.2_2 - 4.6 7.1 7.5 6.2 6.7 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) DUF4413 PF14372.4 MSTRG.20905.1_3 - 0.015 15.5 0.1 0.033 14.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) Kelch_5 PF13854.4 MSTRG.13095.2_1 - 2.6e-32 110.1 1.1 0.00024 20.9 0.0 6.8 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.4 MSTRG.13095.2_1 - 1.1e-30 105.1 4.6 1.4e-05 25.1 0.0 7.1 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.4 MSTRG.13095.2_1 - 2.7e-23 81.5 0.4 0.00079 19.2 0.0 6.7 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.23 MSTRG.13095.2_1 - 5.6e-22 76.9 7.8 3.8e-05 23.0 0.0 6.6 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 MSTRG.13095.2_1 - 2.7e-20 71.8 3.3 0.03 14.5 0.0 7.0 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.13 MSTRG.13095.2_1 - 5.8e-16 57.6 5.5 0.013 15.3 0.0 6.6 6 0 0 6 6 6 5 Kelch motif fn3 PF00041.19 MSTRG.13095.2_1 - 9.6e-09 35.3 0.1 0.044 14.0 0.0 4.4 4 0 0 4 4 4 2 Fibronectin type III domain Sugar_tr PF00083.22 MSTRG.7216.3_2 - 2.4e-25 89.2 20.9 3.7e-25 88.6 20.9 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 MSTRG.7216.3_2 - 1e-22 80.4 27.0 1e-22 80.4 27.0 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily Claudin_2 PF13903.4 MSTRG.20389.1_2 - 1.5e-21 76.9 4.9 2.5e-21 76.2 4.9 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.18 MSTRG.20389.1_2 - 0.02 14.7 8.7 0.12 12.1 3.9 2.4 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin family Actin PF00022.17 MSTRG.20389.1_3 - 3.8e-100 335.2 0.0 9.6e-56 189.0 0.0 3.1 2 1 1 3 3 3 3 Actin MreB_Mbl PF06723.11 MSTRG.20389.1_3 - 0.00092 18.0 0.0 0.73 8.5 0.0 2.8 3 0 0 3 3 3 2 MreB/Mbl protein CN_hydrolase PF00795.20 MSTRG.16563.3_3 - 2.3e-60 204.0 0.0 2.9e-60 203.7 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DEAD PF00270.27 MSTRG.2507.3_2 - 5.4e-48 162.9 0.0 9.1e-48 162.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.2507.3_2 - 7.6e-28 97.0 0.0 3.6e-27 94.8 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.2507.3_2 - 1.4e-06 28.3 0.0 2.2e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.3 MSTRG.2507.3_2 - 0.024 13.7 0.0 0.04 13.0 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Collagen PF01391.16 MSTRG.3536.1_2 - 4.1e-13 48.7 49.9 3.2e-09 36.3 29.8 3.7 3 1 0 3 3 3 3 Collagen triple helix repeat (20 copies) MORN PF02493.18 MSTRG.4397.1_2 - 7.5e-31 104.0 67.2 1e-06 28.1 2.6 8.7 8 0 0 8 8 8 8 MORN repeat Alanine_zipper PF11839.6 MSTRG.4397.1_2 - 2.4 8.3 11.4 6.9 6.9 11.4 1.7 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein Bax1-I PF01027.18 MSTRG.17257.1_3 - 2.8e-34 118.6 28.8 3.4e-34 118.4 28.8 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 OST3_OST6 PF04756.11 MSTRG.17257.1_3 - 0.0096 15.2 8.7 0.018 14.3 0.0 2.4 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family 7TMR-DISM_7TM PF07695.9 MSTRG.17257.1_3 - 4.9 6.9 28.9 0.75 9.5 16.0 2.3 1 1 1 2 2 2 0 7TM diverse intracellular signalling ST7 PF04184.10 MSTRG.65.4_2 - 0.37 9.0 1.3 0.68 8.1 1.3 1.3 1 0 0 1 1 1 0 ST7 protein zf-C2HC_2 PF13913.4 MSTRG.65.4_2 - 4.4 7.2 6.3 0.38 10.6 0.4 2.2 2 0 0 2 2 2 0 zinc-finger of a C2HC-type STAG PF08514.9 MSTRG.26540.1_1 - 3.4e-29 100.9 0.2 5.2e-29 100.3 0.2 1.3 1 0 0 1 1 1 1 STAG domain MerR-DNA-bind PF09278.9 MSTRG.26540.1_1 - 0.13 12.6 1.3 0.28 11.6 1.3 1.5 1 0 0 1 1 1 0 MerR, DNA binding Peptidase_M28 PF04389.15 MSTRG.9118.1_1 - 1.3e-26 93.4 0.0 1.8e-26 92.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.26 MSTRG.9118.1_1 - 2.1e-05 24.2 0.0 3.5e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Herpes_heli_pri PF05774.9 MSTRG.21915.1_2 - 0.2 11.8 3.7 4.6 7.3 1.0 2.2 1 1 1 2 2 2 0 Herpesvirus helicase-primase complex component NupH_GANP PF16768.3 MSTRG.18846.1_2 - 8.6e-20 71.5 94.2 1.4e-14 54.4 53.2 3.4 1 1 2 3 3 3 3 Nucleoporin homology of Germinal-centre associated nuclear protein RRM_1 PF00076.20 MSTRG.18846.1_2 - 7.7e-07 28.7 0.0 1.3e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 MSTRG.18846.1_2 - 0.00034 20.3 0.0 0.0006 19.5 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.4 MSTRG.18846.1_2 - 0.012 15.4 0.0 0.023 14.5 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF1394 PF07159.10 MSTRG.10423.1_3 - 1.8e-138 460.7 0.0 2.2e-138 460.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) zf-H2C2_2 PF13465.4 MSTRG.6894.1_3 - 1e-17 63.6 32.5 2.9e-08 33.7 1.1 5.2 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.6894.1_3 - 2.2e-14 52.9 28.8 0.00047 20.3 0.1 4.9 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.6894.1_3 - 4e-11 42.6 27.6 0.0052 17.4 0.2 5.1 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.6894.1_3 - 1.2e-05 25.3 13.8 0.14 12.4 0.0 4.6 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding BolA PF01722.16 MSTRG.6894.1_3 - 0.4 10.9 6.2 1.1 9.5 1.5 3.3 2 1 1 3 3 3 0 BolA-like protein zf-CHY PF05495.10 MSTRG.6894.1_3 - 0.48 10.9 12.0 1.5 9.3 0.7 2.7 2 0 0 2 2 2 0 CHY zinc finger zf-Di19 PF05605.10 MSTRG.6894.1_3 - 1.7 8.9 13.8 0.13 12.4 3.3 2.8 1 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.8 MSTRG.6894.1_3 - 6.4 6.9 9.1 20 5.3 2.9 2.9 1 1 2 3 3 3 0 Zinc ribbon domain Crust_neuro_H PF03858.11 MSTRG.832.1_2 - 0.0013 19.3 0.1 0.01 16.5 0.1 2.6 1 0 0 1 1 1 1 Crustacean neurohormone H SMC_Nse1 PF07574.11 MSTRG.11454.2_3 - 3e-21 76.1 0.4 1.4e-19 70.7 0.4 2.1 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.9 MSTRG.11454.2_3 - 1.1e-11 44.7 8.1 1.1e-11 44.7 8.1 2.6 2 0 0 2 2 2 1 RING-like domain FANCL_C PF11793.6 MSTRG.11454.2_3 - 0.022 14.8 3.0 0.022 14.8 3.0 2.3 2 1 0 2 2 2 0 FANCL C-terminal domain DUF1335 PF07056.9 MSTRG.11454.2_3 - 0.024 14.6 0.5 0.047 13.7 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1335) UPF0270 PF06794.10 MSTRG.11454.2_3 - 0.12 12.3 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0270) Coronavirus_5 PF05528.9 MSTRG.11454.2_3 - 0.34 10.8 3.3 0.32 10.9 0.5 2.2 1 1 1 2 2 2 0 Coronavirus gene 5 protein FXa_inhibition PF14670.4 MSTRG.23740.1_2 - 3.4e-28 97.5 46.9 1.3e-11 44.5 14.2 3.2 3 0 0 3 3 3 3 Coagulation Factor Xa inhibitory site EGF_CA PF07645.13 MSTRG.23740.1_2 - 6.9e-22 77.2 38.6 7.6e-11 41.9 4.8 3.1 3 0 0 3 3 3 3 Calcium-binding EGF domain cEGF PF12662.5 MSTRG.23740.1_2 - 8.5e-19 67.0 8.9 2.3e-11 43.3 0.8 4.5 5 1 0 5 5 5 3 Complement Clr-like EGF-like EGF_3 PF12947.5 MSTRG.23740.1_2 - 1.8e-07 31.1 37.1 0.00019 21.4 4.3 3.7 2 1 0 3 3 3 2 EGF domain EGF PF00008.25 MSTRG.23740.1_2 - 3.9e-07 30.1 25.1 0.00018 21.6 9.0 4.0 4 1 0 4 4 4 2 EGF-like domain hEGF PF12661.5 MSTRG.23740.1_2 - 0.015 15.8 6.0 0.015 15.8 6.0 6.0 5 2 1 6 6 6 0 Human growth factor-like EGF RRM_1 PF00076.20 MSTRG.18843.2_1 - 6.6e-43 144.3 0.5 3.3e-15 55.5 0.4 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.18843.2_1 - 5e-08 32.8 0.1 0.11 12.6 0.0 4.3 2 2 1 3 3 3 3 RNA recognition motif RRM_5 PF13893.4 MSTRG.18843.2_1 - 9.4e-07 28.3 0.0 1.8e-05 24.2 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.6 MSTRG.18843.2_1 - 0.00071 19.5 0.0 0.86 9.6 0.1 3.4 3 0 0 3 3 3 1 Limkain b1 Nup35_RRM_2 PF14605.4 MSTRG.18843.2_1 - 0.0019 18.0 0.1 11 5.9 0.0 3.5 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif DUF1866 PF08952.9 MSTRG.18843.2_1 - 0.049 13.3 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1866) RRM_occluded PF16842.3 MSTRG.18843.2_1 - 0.057 13.2 0.0 1.6 8.5 0.0 2.7 3 0 0 3 3 3 0 Occluded RNA-recognition motif IPK PF03770.14 MSTRG.17689.1_2 - 1.8e-37 129.0 0.0 3.5e-37 128.0 0.0 1.5 1 0 0 1 1 1 1 Inositol polyphosphate kinase DHO_dh PF01180.19 MSTRG.17689.1_2 - 0.016 14.3 0.0 0.024 13.7 0.0 1.2 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase Sec63 PF02889.14 MSTRG.23403.1_3 - 1.5e-18 66.7 2.2 5.8e-09 35.3 0.3 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DnaJ PF00226.29 MSTRG.23403.1_3 - 5.2e-15 55.2 0.0 1.4e-14 53.8 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain DSPc PF00782.18 MSTRG.2143.1_3 - 2e-35 121.4 0.0 2.8e-35 120.9 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain MFS_1 PF07690.14 MSTRG.3722.1_1 - 2.7e-34 118.5 30.9 1.6e-23 83.0 14.8 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 MSTRG.3722.1_1 - 1.3e-32 113.1 20.4 2.1e-26 92.7 6.4 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter Pentapeptide_4 PF13599.4 MSTRG.3722.1_1 - 2.4e-05 24.2 6.9 5.6e-05 23.1 6.9 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) MFS_4 PF06779.12 MSTRG.3722.1_1 - 0.00023 20.5 7.1 0.00023 20.5 7.1 2.0 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB MFS_2 PF13347.4 MSTRG.3722.1_1 - 0.00052 18.6 7.6 0.00052 18.6 7.6 2.5 2 0 0 2 2 2 2 MFS/sugar transport protein MFS_3 PF05977.11 MSTRG.3722.1_1 - 0.25 9.6 9.1 0.24 9.6 3.3 2.2 2 0 0 2 2 2 0 Transmembrane secretion effector YL1 PF05764.11 MSTRG.3722.1_1 - 2.8 7.9 7.7 4.6 7.2 7.7 1.2 1 0 0 1 1 1 0 YL1 nuclear protein F-actin_cap_A PF01267.15 MSTRG.22569.1_1 - 5.2e-104 347.2 0.2 6.6e-104 346.9 0.2 1.1 1 0 0 1 1 1 1 F-actin capping protein alpha subunit SPRY PF00622.26 MSTRG.14121.4_3 - 6.4e-22 77.8 0.0 5.8e-10 39.2 0.0 3.4 3 0 0 3 3 3 3 SPRY domain DDRGK PF09756.7 MSTRG.6259.1_1 - 7.3e-67 224.5 30.3 7.3e-67 224.5 30.3 2.2 2 0 0 2 2 2 2 DDRGK domain FeoC PF09012.8 MSTRG.6259.1_1 - 0.00061 19.7 0.1 0.54 10.2 0.0 2.5 2 0 0 2 2 2 2 FeoC like transcriptional regulator TFIIA PF03153.11 MSTRG.6259.1_1 - 0.89 9.4 28.0 1.2 8.9 28.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit rve PF00665.24 MSTRG.21423.1_1 - 3.4e-06 27.1 0.0 6.6e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain CD225 PF04505.10 MSTRG.21423.1_2 - 1.3e-21 76.3 0.0 1.3e-21 76.3 0.0 3.1 2 1 0 2 2 2 1 Interferon-induced transmembrane protein DNase_II PF03265.13 MSTRG.3699.1_2 - 2.6e-105 352.2 0.0 3.4e-105 351.8 0.0 1.1 1 0 0 1 1 1 1 Deoxyribonuclease II Glyco_transf_29 PF00777.16 MSTRG.795.1_3 - 1.4e-39 136.0 0.0 2e-39 135.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Ribosomal_S17_N PF16205.3 MSTRG.24664.4_2 - 5.7e-21 74.5 1.0 6.6e-11 42.3 0.5 2.2 2 0 0 2 2 2 2 Ribosomal_S17 N-terminal SH3_1 PF00018.26 MSTRG.14002.2_2 - 9.3e-11 41.0 0.0 1.4e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.14002.2_2 - 2.5e-10 39.9 0.0 4.3e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.14002.2_2 - 4.6e-10 38.9 0.0 8.8e-10 38.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain adh_short PF00106.23 MSTRG.1549.1_2 - 3.4e-45 153.8 0.2 5.7e-45 153.0 0.2 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 MSTRG.1549.1_2 - 3.5e-43 147.7 0.1 5e-43 147.2 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 MSTRG.1549.1_2 - 1.4e-09 38.0 0.4 2.7e-09 37.1 0.4 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.19 MSTRG.1549.1_2 - 0.045 13.1 0.0 0.08 12.3 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.17 MSTRG.1549.1_2 - 0.09 11.6 0.0 0.25 10.1 0.0 1.6 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family GETHR PF05671.9 MSTRG.17543.1_1 - 3.8 6.8 10.5 7.1 6.0 0.4 3.8 4 0 0 4 4 4 0 GETHR pentapeptide repeat (5 copies) zf-H2C2_2 PF13465.4 MSTRG.17543.1_2 - 1.4e-52 173.7 48.9 8.2e-09 35.4 0.4 8.7 8 0 0 8 8 8 7 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.17543.1_2 - 3.2e-37 124.8 42.8 3.5e-05 23.9 0.2 7.9 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.17543.1_2 - 1.7e-30 102.9 40.4 0.00082 19.9 0.3 8.0 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.17543.1_2 - 8.3e-17 60.6 30.8 0.0088 15.8 0.2 7.7 7 0 0 7 7 7 6 C2H2-type zinc finger zf-met PF12874.5 MSTRG.17543.1_2 - 6.8e-09 35.7 34.1 0.061 13.6 0.5 7.6 7 0 0 7 7 7 5 Zinc-finger of C2H2 type zf-Di19 PF05605.10 MSTRG.17543.1_2 - 2.4e-06 27.6 21.2 0.022 14.9 0.6 4.5 1 1 5 6 6 6 5 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.6 MSTRG.17543.1_2 - 2.9e-06 27.3 10.4 1.2 9.4 0.0 7.3 7 0 0 7 7 7 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 MSTRG.17543.1_2 - 0.00072 19.7 19.5 11 6.2 3.2 7.0 1 1 3 5 5 5 0 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.8 MSTRG.17543.1_2 - 0.0017 18.3 18.0 0.94 9.5 0.9 5.4 2 1 3 5 5 5 2 Zinc ribbon domain zf-C2H2_11 PF16622.3 MSTRG.17543.1_2 - 0.0061 16.2 22.4 1.8 8.3 0.2 7.2 7 0 0 7 7 7 1 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 MSTRG.17543.1_2 - 0.0069 17.0 13.7 1.7 9.3 2.2 4.6 2 2 2 4 4 4 1 zinc-ribbon family LIM PF00412.20 MSTRG.17543.1_2 - 0.059 13.5 23.3 40 4.4 7.8 6.3 1 1 6 7 7 7 0 LIM domain zf-C2HE PF16278.3 MSTRG.17543.1_2 - 0.24 11.8 31.6 6.9 7.1 0.9 7.3 1 1 5 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_5 PF13909.4 MSTRG.17543.1_2 - 0.81 9.4 34.4 0.27 10.9 1.2 7.4 7 0 0 7 7 7 0 C2H2-type zinc-finger domain Elf1 PF05129.11 MSTRG.17543.1_2 - 2.3 8.2 24.4 0.055 13.4 1.9 4.7 1 1 3 4 4 4 0 Transcription elongation factor Elf1 like DUF3268 PF11672.6 MSTRG.17543.1_2 - 4.1 7.6 10.0 18 5.6 0.1 3.7 3 1 0 4 4 3 0 zinc-finger-containing domain zf-LYAR PF08790.9 MSTRG.17543.1_2 - 4.6 7.1 28.1 9.6 6.1 0.2 8.0 8 0 0 8 8 8 0 LYAR-type C2HC zinc finger ADK_lid PF05191.12 MSTRG.17543.1_2 - 6.2 6.8 13.1 2.9 7.9 0.3 4.3 3 1 0 3 3 3 0 Adenylate kinase, active site lid zf-CHCC PF10276.7 MSTRG.17543.1_2 - 7.1 6.6 17.8 51 3.9 0.3 6.2 6 0 0 6 6 6 0 Zinc-finger domain Neural_ProG_Cyt PF06567.9 MSTRG.3600.5_1 - 4.5e-62 207.4 3.4 6e-62 207.0 3.4 1.2 1 0 0 1 1 1 1 Neural chondroitin sulphate proteoglycan cytoplasmic domain adh_short PF00106.23 MSTRG.8876.3_2 - 4e-31 107.9 0.4 4.3e-29 101.2 0.4 2.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 MSTRG.8876.3_2 - 3.6e-20 72.4 0.5 3.3e-12 46.4 0.1 2.4 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 MSTRG.8876.3_2 - 6.9e-09 35.7 0.1 1.4e-08 34.7 0.1 1.5 1 0 0 1 1 1 1 KR domain Hpr_kinase_C PF07475.10 MSTRG.8876.3_2 - 0.027 13.9 0.0 0.038 13.4 0.0 1.2 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain MIF4G PF02854.17 MSTRG.2612.2_2 - 1e-64 217.9 10.2 1.8e-64 217.2 10.2 1.4 1 0 0 1 1 1 1 MIF4G domain MA3 PF02847.15 MSTRG.2612.2_2 - 1.8e-28 98.6 0.1 5.6e-28 97.0 0.1 1.9 1 0 0 1 1 1 1 MA3 domain W2 PF02020.16 MSTRG.2612.2_2 - 3.1e-19 68.8 6.7 5.9e-19 67.9 0.4 3.1 3 0 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon PP_kinase PF02503.15 MSTRG.2612.2_2 - 0.0046 16.4 1.4 0.0086 15.6 1.4 1.3 1 0 0 1 1 1 1 Polyphosphate kinase middle domain YqhG PF11079.6 MSTRG.2612.2_2 - 0.11 11.3 1.0 0.18 10.6 1.0 1.3 1 0 0 1 1 1 0 Bacterial protein YqhG of unknown function Glyco_transf_7C PF02709.12 MSTRG.8067.1_3 - 6.4e-27 92.9 0.2 1.1e-26 92.1 0.2 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_transf_7N PF13733.4 MSTRG.8067.1_3 - 7.3e-23 80.6 0.0 1.2e-22 79.8 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 VGLL4 PF15245.4 MSTRG.2907.1_3 - 1.5e-44 152.5 6.9 1.5e-44 152.5 6.9 1.8 2 0 0 2 2 2 1 Transcription cofactor vestigial-like protein 4 Vg_Tdu PF07545.12 MSTRG.2907.1_3 - 3e-05 23.5 0.2 0.077 12.6 0.1 2.7 2 0 0 2 2 2 2 Vestigial/Tondu family RasGEF PF00617.17 MSTRG.19008.2_1 - 3e-50 170.7 0.0 5.7e-50 169.7 0.0 1.5 1 0 0 1 1 1 1 RasGEF domain RA PF00788.21 MSTRG.19008.2_1 - 2e-13 50.7 0.1 5.3e-13 49.3 0.1 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain RasGEF_N PF00618.18 MSTRG.19008.2_1 - 6.6e-12 45.5 0.3 8.8e-11 41.9 0.3 2.5 1 1 0 1 1 1 1 RasGEF N-terminal motif Ephrin PF00812.15 MSTRG.9033.1_3 - 6.9e-38 129.6 0.6 1.3e-37 128.7 0.6 1.5 1 0 0 1 1 1 1 Ephrin Exo_endo_phos_2 PF14529.4 MSTRG.18093.1_1 - 4.4e-07 29.6 0.6 6.6e-07 29.1 0.6 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Apelin PF15360.4 MSTRG.10761.1_1 - 5 7.6 7.4 0.19 12.2 0.5 2.3 2 0 0 2 2 2 0 APJ endogenous ligand DUF947 PF06102.10 MSTRG.19328.1_3 - 4.5e-35 120.9 16.2 5.3e-35 120.7 16.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF947) DUF4770 PF15994.3 MSTRG.19328.1_3 - 0.54 10.3 4.3 0.36 10.9 2.8 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4770) Nebulin PF00880.16 MSTRG.1479.16_1 - 0 1855.0 670.6 2.8e-10 39.8 2.0 157.8 164 0 0 164 164 164 126 Nebulin repeat Peptidase_M24 PF00557.22 MSTRG.1479.16_1 - 3.4e-18 66.0 3.5 0.31 10.6 0.0 11.3 11 0 0 11 11 11 7 Metallopeptidase family M24 SH3_1 PF00018.26 MSTRG.1479.16_1 - 3.3e-12 45.7 0.0 1.6e-11 43.4 0.0 2.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.1479.16_1 - 3.8e-12 45.7 0.0 8.2e-12 44.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.1479.16_1 - 9.5e-06 25.1 0.0 8.8e-05 22.0 0.0 2.8 2 0 0 2 2 2 1 Variant SH3 domain Toprim_2 PF13155.4 MSTRG.1479.16_1 - 0.67 10.4 7.7 76 3.8 0.0 6.1 6 0 0 6 6 6 0 Toprim-like Ank_2 PF12796.5 MSTRG.19400.1_2 - 9.4e-152 493.9 44.1 1.5e-17 63.8 0.3 13.8 1 1 13 15 15 15 15 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.19400.1_2 - 5e-136 441.4 49.2 1.7e-14 53.9 0.1 19.5 6 4 15 22 22 22 22 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.19400.1_2 - 5.6e-132 424.9 73.9 4.8e-07 29.8 0.1 27.5 26 1 1 27 27 27 26 Ankyrin repeat Ank_5 PF13857.4 MSTRG.19400.1_2 - 6e-109 354.1 61.5 4.7e-09 36.2 0.0 20.6 7 5 15 22 22 22 22 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.19400.1_2 - 3.1e-99 312.7 51.7 3.2e-06 26.9 0.1 27.8 28 0 0 28 28 28 25 Ankyrin repeat SIR2 PF02146.15 MSTRG.14745.6_1 - 1.3e-30 106.5 0.0 1.8e-30 106.0 0.0 1.2 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.11 MSTRG.14745.6_1 - 0.0032 17.1 0.7 0.0054 16.4 0.6 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF592) zf-H2C2_2 PF13465.4 MSTRG.19139.1_2 - 7.6e-31 105.0 50.5 9.9e-07 28.8 3.0 7.8 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.19139.1_2 - 5.4e-25 86.3 47.7 0.00014 22.0 0.5 8.3 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.19139.1_2 - 6.9e-19 66.8 57.4 0.0045 17.6 1.0 8.6 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.19139.1_2 - 4.1e-10 39.6 22.8 0.039 14.1 0.1 7.7 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.19139.1_2 - 1.1e-05 25.5 31.4 0.34 11.2 1.2 6.6 6 0 0 6 6 6 4 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 MSTRG.19139.1_2 - 0.00084 19.1 41.5 0.12 12.2 0.4 7.7 7 0 0 7 7 7 4 C2H2-type zinc finger zf-C2H2_2 PF12756.5 MSTRG.19139.1_2 - 0.003 17.7 22.4 0.13 12.5 0.0 6.1 1 1 4 6 6 6 2 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.10 MSTRG.19139.1_2 - 0.01 16.0 28.4 0.33 11.1 0.3 5.3 2 1 1 4 4 4 3 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_9 PF14369.4 MSTRG.19139.1_2 - 0.036 14.2 16.5 0.24 11.6 0.5 5.6 5 1 1 6 6 6 0 zinc-ribbon GAGA PF09237.9 MSTRG.19139.1_2 - 1.2 8.8 5.6 3.9 7.2 0.2 4.4 3 2 3 6 6 6 0 GAGA factor zf-RING_2 PF13639.4 MSTRG.11232.1_1 - 3.5e-09 36.6 4.2 3.5e-09 36.6 4.2 2.4 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.3 MSTRG.11232.1_1 - 8.5e-06 25.2 3.8 8.5e-06 25.2 3.8 2.1 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4_2 PF13923.4 MSTRG.11232.1_1 - 4.6e-05 23.1 6.9 5.4e-05 22.8 3.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.11232.1_1 - 0.0012 18.6 4.3 0.0012 18.6 4.3 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.5 MSTRG.11232.1_1 - 0.0034 17.5 1.6 0.0034 17.5 1.6 2.4 3 0 0 3 3 3 1 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.3 MSTRG.11232.1_1 - 0.0072 15.8 2.7 0.023 14.2 2.7 1.9 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type RNF220 PF15926.3 MSTRG.11232.1_1 - 0.15 11.6 0.3 0.24 10.9 0.3 1.2 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 zf-C3HC4 PF00097.23 MSTRG.11232.1_1 - 0.17 11.6 9.9 0.024 14.4 4.0 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.5 MSTRG.11232.1_1 - 0.24 11.4 4.8 0.61 10.1 4.8 1.7 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.6 MSTRG.11232.1_1 - 0.39 10.8 5.7 0.22 11.6 2.7 2.1 2 0 0 2 2 2 0 FANCL C-terminal domain zf-C3HC4_3 PF13920.4 MSTRG.11232.1_1 - 0.57 10.0 5.2 1.1 9.0 2.2 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.9 MSTRG.11232.1_1 - 1.7 8.9 6.2 0.36 11.0 2.3 2.0 2 0 0 2 2 1 0 RING-like domain Prok-RING_1 PF14446.4 MSTRG.11232.1_1 - 3.5 7.5 8.1 4.4 7.2 3.3 2.5 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Septin PF00735.16 MSTRG.1914.1_3 - 6.7e-127 422.4 0.5 9.1e-127 422.0 0.5 1.1 1 0 0 1 1 1 1 Septin DUF258 PF03193.14 MSTRG.1914.1_3 - 5.1e-09 36.1 0.1 1.5e-05 24.8 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 MSTRG.1914.1_3 - 3.9e-08 33.2 0.0 1.1e-07 31.9 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 MSTRG.1914.1_3 - 7.5e-05 22.2 1.3 0.073 12.5 0.0 2.5 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.14 MSTRG.1914.1_3 - 0.00096 18.4 0.0 0.0022 17.2 0.0 1.6 1 0 0 1 1 1 1 AIG1 family AAA_23 PF13476.4 MSTRG.1914.1_3 - 0.0026 18.2 0.1 0.015 15.7 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 MSTRG.1914.1_3 - 0.0041 17.4 0.0 0.0085 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain Ras PF00071.20 MSTRG.1914.1_3 - 0.013 14.9 0.1 0.03 13.8 0.1 1.6 1 0 0 1 1 1 0 Ras family Roc PF08477.11 MSTRG.1914.1_3 - 0.02 15.0 0.1 0.041 14.0 0.1 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.4 MSTRG.1914.1_3 - 0.026 14.1 0.0 0.056 13.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.4 MSTRG.1914.1_3 - 0.027 14.6 0.3 0.12 12.5 0.0 2.2 2 1 0 2 2 2 0 AAA domain Dynamin_N PF00350.21 MSTRG.1914.1_3 - 0.037 13.9 6.3 0.45 10.4 0.0 3.0 3 1 1 4 4 4 0 Dynamin family ABC_tran PF00005.25 MSTRG.1914.1_3 - 0.04 14.3 0.2 0.1 13.0 0.2 1.7 1 1 0 1 1 1 0 ABC transporter NACHT PF05729.10 MSTRG.1914.1_3 - 0.093 12.5 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 NACHT domain zf-H2C2_2 PF13465.4 MSTRG.14230.1_3 - 4.5e-33 112.1 76.3 1.3e-08 34.8 2.1 11.5 12 0 0 12 12 12 9 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.14230.1_3 - 1.5e-32 109.3 76.0 0.00039 20.9 0.4 10.8 10 0 0 10 10 10 10 C2H2-type zinc finger zf-C2H2 PF00096.24 MSTRG.14230.1_3 - 5.8e-28 95.6 81.9 0.00046 20.4 0.5 10.6 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.14230.1_3 - 2e-15 56.5 36.1 0.00012 22.1 1.9 10.2 10 0 0 10 10 10 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 MSTRG.14230.1_3 - 6.1e-09 35.5 68.5 0.0019 17.9 1.5 10.3 10 0 0 10 10 10 6 C2H2-type zinc finger zf-C2H2_11 PF16622.3 MSTRG.14230.1_3 - 5.7e-05 22.7 37.4 0.0035 16.9 0.0 8.5 9 0 0 9 9 9 3 zinc-finger C2H2-type zf-C2H2_2 PF12756.5 MSTRG.14230.1_3 - 0.0012 19.1 48.4 0.77 10.0 0.9 9.0 3 2 6 9 9 9 2 C2H2 type zinc-finger (2 copies) zf-met PF12874.5 MSTRG.14230.1_3 - 0.0018 18.5 51.5 0.029 14.6 2.1 9.0 9 0 0 9 9 9 3 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.3 MSTRG.14230.1_3 - 0.016 15.3 1.9 0.016 15.3 1.9 5.6 3 2 4 7 7 7 0 C2H2-type zinc ribbon Zn-ribbon_8 PF09723.8 MSTRG.14230.1_3 - 0.056 13.4 35.8 4.1 7.5 0.4 7.8 5 2 2 8 8 8 0 Zinc ribbon domain zf-C2HC_2 PF13913.4 MSTRG.14230.1_3 - 0.074 12.9 40.8 0.14 12.0 0.5 7.7 8 0 0 8 8 8 0 zinc-finger of a C2HC-type zinc_ribbon_15 PF17032.3 MSTRG.14230.1_3 - 0.3 11.7 27.1 0.78 10.4 2.0 5.6 3 2 3 6 6 6 0 zinc-ribbon family zf-RING_7 PF02591.13 MSTRG.14230.1_3 - 0.44 10.6 7.5 1.4 9.0 0.1 3.7 3 0 0 3 3 2 0 C4-type zinc ribbon domain FYVE PF01363.19 MSTRG.14230.1_3 - 2 8.5 46.2 0.31 11.1 4.1 6.8 4 2 1 5 5 5 0 FYVE zinc finger zf-Di19 PF05605.10 MSTRG.14230.1_3 - 8.2 6.7 44.2 0.61 10.3 1.1 6.8 3 2 6 9 9 9 0 Drought induced 19 protein (Di19), zinc-binding GAGA PF09237.9 MSTRG.14230.1_3 - 8.7 6.1 14.0 1.1 9.0 0.2 4.9 4 2 2 6 6 6 0 GAGA factor PEN-2 PF10251.7 MSTRG.17153.3_3 - 3.2e-39 133.1 2.1 5e-39 132.5 2.1 1.3 1 0 0 1 1 1 1 Presenilin enhancer-2 subunit of gamma secretase Med9 PF07544.11 MSTRG.9270.1_3 - 2.5e-22 78.6 2.6 3.9e-22 78.0 2.6 1.3 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Med21 PF11221.6 MSTRG.9270.1_3 - 0.0072 16.5 1.5 0.0072 16.5 1.5 1.7 2 0 0 2 2 2 1 Subunit 21 of Mediator complex ELK PF03789.11 MSTRG.9270.1_3 - 0.15 12.1 0.4 0.37 10.8 0.4 1.7 1 0 0 1 1 1 0 ELK domain TNFR_c6 PF00020.16 MSTRG.17646.1_3 - 5.2e-13 49.0 34.0 7.8e-09 35.7 12.2 4.0 4 0 0 4 4 4 2 TNFR/NGFR cysteine-rich region Death PF00531.20 MSTRG.17646.1_3 - 6.5e-12 45.3 0.1 1.2e-11 44.4 0.1 1.4 1 0 0 1 1 1 1 Death domain DUF4366 PF14283.4 MSTRG.17646.1_3 - 0.014 14.7 0.1 0.032 13.6 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) SIR2 PF02146.15 MSTRG.14745.2_2 - 3.4e-45 154.0 0.0 5.6e-45 153.3 0.0 1.4 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.20 MSTRG.14745.2_2 - 0.18 11.4 0.0 0.3 10.7 0.0 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain CD34_antigen PF06365.10 MSTRG.20439.1_1 - 4.8e-18 65.4 0.0 8.6e-18 64.6 0.0 1.4 1 0 0 1 1 1 1 CD34/Podocalyxin family RNase_PH PF01138.19 MSTRG.911.1_1 - 7.1e-27 94.4 0.0 2e-26 92.9 0.0 1.7 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.13 MSTRG.911.1_1 - 1.5e-09 37.6 0.0 2.8e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 PDZ PF00595.22 MSTRG.11271.2_2 - 4.5e-05 23.6 0.0 7.4e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.11271.2_2 - 0.00031 20.9 0.0 0.001 19.2 0.0 1.8 1 1 1 2 2 2 1 PDZ domain L27 PF02828.14 MSTRG.11271.2_2 - 0.15 11.8 0.3 0.28 10.9 0.3 1.4 1 0 0 1 1 1 0 L27 domain Tex_YqgF PF16921.3 MSTRG.26319.1_3 - 1.9e-44 151.0 0.0 5.6e-44 149.5 0.0 1.8 2 0 0 2 2 2 1 Tex protein YqgF-like domain Tex_N PF09371.8 MSTRG.26319.1_3 - 2.3e-40 137.9 0.1 1.6e-39 135.1 0.0 2.0 2 0 0 2 2 2 1 Tex-like protein N-terminal domain HHH_3 PF12836.5 MSTRG.26319.1_3 - 1.3e-20 73.2 0.0 2.6e-20 72.3 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif S1 PF00575.21 MSTRG.26319.1_3 - 1.2e-12 47.9 0.0 5e-12 45.9 0.0 2.1 1 0 0 1 1 1 1 S1 RNA binding domain HHH_7 PF14635.4 MSTRG.26319.1_3 - 2.3e-06 27.7 0.0 5.4e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.4 MSTRG.26319.1_3 - 5.5e-05 22.9 0.0 0.00013 21.6 0.0 1.7 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 DLD PF14878.4 MSTRG.26319.1_3 - 0.044 14.3 0.0 0.12 12.9 0.0 1.7 1 0 0 1 1 1 0 Death-like domain of SPT6 KTI12 PF08433.8 MSTRG.2389.1_1 - 9.4e-104 346.5 0.1 1.1e-103 346.3 0.1 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.4 MSTRG.2389.1_1 - 4.6e-09 36.4 0.0 1.1e-08 35.2 0.0 1.6 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.10 MSTRG.2389.1_1 - 0.023 13.9 0.0 0.048 12.8 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.4 MSTRG.2389.1_1 - 0.023 15.1 0.0 0.064 13.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain Viral_coat PF00729.16 MSTRG.2389.1_1 - 0.15 11.7 0.1 0.15 11.7 0.1 1.6 2 0 0 2 2 2 0 Viral coat protein (S domain) SET PF00856.26 MSTRG.5949.3_2 - 1.1e-10 42.0 0.1 1.1e-10 42.0 0.1 2.5 3 0 0 3 3 3 1 SET domain DUF3970 PF13113.4 MSTRG.5949.3_2 - 0.075 13.1 1.6 0.18 11.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3970) 14-3-3 PF00244.18 MSTRG.26611.1_3 - 6.2e-103 342.9 10.7 8.4e-103 342.5 10.7 1.2 1 0 0 1 1 1 1 14-3-3 protein FliM PF02154.13 MSTRG.26611.1_3 - 0.12 12.1 0.1 0.2 11.4 0.1 1.2 1 0 0 1 1 1 0 Flagellar motor switch protein FliM Pkinase PF00069.23 MSTRG.8404.1_1 - 0.00017 20.9 0.0 0.00021 20.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain ABC_membrane_2 PF06472.13 MSTRG.24436.2_2 - 1.5e-98 329.5 4.7 2.2e-98 329.0 4.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.25 MSTRG.24436.2_2 - 3.3e-06 27.5 0.0 7.8e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.4 MSTRG.24436.2_2 - 0.00019 21.2 0.0 0.00034 20.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.4 MSTRG.24436.2_2 - 0.0035 17.7 0.0 0.009 16.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain Adeno_IVa2 PF02456.13 MSTRG.24436.2_2 - 0.0083 14.8 0.1 0.016 13.9 0.0 1.5 1 1 0 1 1 1 1 Adenovirus IVa2 protein AAA_29 PF13555.4 MSTRG.24436.2_2 - 0.012 15.1 0.0 0.028 14.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.17 MSTRG.24436.2_2 - 0.15 11.3 0.1 0.3 10.4 0.1 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain DUF4603 PF15376.4 MSTRG.24472.2_1 - 0 1884.6 24.7 0 1884.3 24.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4603) DUF4603 PF15376.4 MSTRG.24472.2_3 - 8.5e-67 225.4 0.0 1.1e-66 225.1 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4603) DUF2365 PF10157.7 MSTRG.3144.2_1 - 2.3e-56 190.1 0.2 3.4e-56 189.6 0.2 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2365) BLOC1_2 PF10046.7 MSTRG.3144.2_1 - 0.082 13.1 0.2 4 7.7 0.0 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF755 PF05501.9 MSTRG.3144.2_1 - 0.47 10.6 4.5 0.92 9.7 4.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Sec63 PF02889.14 MSTRG.13384.2_3 - 8.2e-52 175.8 0.1 1.6e-51 174.8 0.1 1.5 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.27 MSTRG.13384.2_3 - 2.2e-27 95.8 0.2 2.1e-26 92.6 0.2 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.13 MSTRG.13384.2_3 - 1.3e-11 44.7 0.0 3.2e-11 43.4 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.29 MSTRG.13384.2_3 - 1.6e-06 28.3 0.0 2.4e-05 24.5 0.0 3.0 2 1 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.4 MSTRG.13384.2_3 - 0.0021 18.2 0.2 0.013 15.7 0.1 2.4 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.4 MSTRG.13384.2_3 - 0.045 14.0 0.2 0.13 12.5 0.2 1.7 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.15 MSTRG.13384.2_3 - 0.068 12.8 0.2 0.32 10.6 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein Elf-1_N PF12310.6 MSTRG.12053.1_2 - 1.3e-05 25.5 0.0 2.1e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Transcription factor protein N terminal Ets PF00178.20 MSTRG.12053.1_3 - 1.1e-34 118.6 0.5 1.9e-34 117.8 0.5 1.4 1 0 0 1 1 1 1 Ets-domain FAM177 PF14774.4 MSTRG.12053.1_3 - 0.088 13.0 0.4 0.45 10.8 0.9 1.9 2 0 0 2 2 2 0 FAM177 family BCDHK_Adom3 PF10436.7 MSTRG.25402.1_1 - 2.6e-52 176.7 0.0 3.7e-52 176.2 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.24 MSTRG.25402.1_1 - 2.7e-13 50.3 0.0 4.5e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Anemone_cytotox PF06369.10 MSTRG.5230.2_3 - 5.4e-16 58.6 0.2 8.4e-16 58.0 0.2 1.2 1 0 0 1 1 1 1 Sea anemone cytotoxic protein CAC1F_C PF16885.3 MSTRG.9343.1_2 - 2.2e-56 192.0 10.5 9.1e-55 186.7 10.5 2.2 1 1 0 1 1 1 1 Voltage-gated calcium channel subunit alpha, C-term Ca_chan_IQ PF08763.9 MSTRG.9343.1_2 - 6.1e-17 61.5 0.1 1.1e-16 60.7 0.1 1.5 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain FA_desaturase PF00487.22 MSTRG.26246.1_1 - 3.6e-17 62.9 17.8 3.6e-17 62.9 17.8 1.6 1 1 0 1 1 1 1 Fatty acid desaturase Cation_ATPase_C PF00689.19 MSTRG.10874.1_3 - 3.1e-05 23.6 5.1 3.1e-05 23.6 5.1 1.8 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus GCV_T PF01571.19 MSTRG.536.1_3 - 2.4e-86 289.1 0.0 3.4e-86 288.6 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.9 MSTRG.536.1_3 - 3.8e-26 91.0 0.1 6.5e-26 90.3 0.1 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Sharpin_PH PF16764.3 MSTRG.12840.1_1 - 2.4e-49 166.0 0.3 8.9e-49 164.2 0.2 1.9 2 0 0 2 2 2 1 Sharpin PH domain zf-RanBP PF00641.16 MSTRG.12840.1_1 - 3.2e-06 26.2 3.6 1e-05 24.6 3.6 2.0 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others ubiquitin PF00240.21 MSTRG.12840.1_1 - 0.00031 20.3 0.0 0.00064 19.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Ima1_N PF09779.7 MSTRG.12840.1_1 - 0.15 12.8 6.5 0.32 11.7 6.5 1.4 1 0 0 1 1 1 0 Ima1 N-terminal domain WD40 PF00400.30 MSTRG.19159.3_3 - 8.6e-10 38.9 9.6 0.061 14.1 0.1 7.2 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.19159.3_3 - 8.4e-05 22.7 0.0 1.5 9.1 0.0 3.6 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Cadherin_3 PF16184.3 MSTRG.18548.1_1 - 1e-223 727.3 19.5 6.3e-29 100.1 0.2 13.2 13 0 0 13 13 13 12 Cadherin-like Calx-beta PF03160.12 MSTRG.18548.1_1 - 1e-73 243.7 3.8 4.2e-16 58.8 0.0 5.7 5 0 0 5 5 5 5 Calx-beta domain VWC PF00093.16 MSTRG.18548.1_1 - 3.5e-34 116.8 136.3 1.9e-09 37.5 17.0 16.9 14 3 3 17 17 17 6 von Willebrand factor type C domain Furin-like_2 PF15913.3 MSTRG.18548.1_1 - 6.1e-06 26.2 43.8 9.8e-06 25.6 19.5 13.3 4 2 10 15 15 15 7 Furin-like repeat, cysteine-rich VSP PF03302.11 MSTRG.18548.1_1 - 1.6e-05 23.8 31.1 3.5e-05 22.7 3.1 12.6 1 1 10 11 11 11 8 Giardia variant-specific surface protein GF_recep_IV PF14843.4 MSTRG.18548.1_1 - 1.7e-05 24.5 33.9 1.7e-05 24.5 33.9 11.9 2 1 12 14 14 14 6 Growth factor receptor domain IV zf-C2H2_2 PF12756.5 MSTRG.25468.5_1 - 0.1 12.8 0.1 0.1 12.8 0.1 1.9 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) HOIP-UBA PF16678.3 MSTRG.1076.1_3 - 1.9e-58 196.7 0.3 3.1e-58 196.0 0.3 1.4 1 0 0 1 1 1 1 UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase IBR PF01485.19 MSTRG.1076.1_3 - 1.9e-07 31.1 32.4 7.3e-06 26.0 13.5 6.8 5 2 1 6 6 6 3 IBR domain, a half RING-finger domain zf-RanBP PF00641.16 MSTRG.1076.1_3 - 0.00054 19.1 2.4 0.00054 19.1 2.4 6.5 11 0 0 11 11 11 2 Zn-finger in Ran binding protein and others UBA PF00627.29 MSTRG.1076.1_3 - 0.0035 17.1 0.1 11 5.9 0.0 3.7 4 0 0 4 4 4 2 UBA/TS-N domain zf-B_box PF00643.22 MSTRG.1076.1_3 - 0.0078 16.2 7.2 0.0078 16.2 7.2 8.2 8 0 0 8 8 8 2 B-box zinc finger DUF3498 PF12004.6 MSTRG.10429.3_1 - 1.5e-36 126.6 9.6 2e-36 126.2 9.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3498) TBPIP PF07106.11 MSTRG.10429.3_1 - 0.081 12.6 1.4 0.12 12.0 1.4 1.1 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF3498 PF12004.6 MSTRG.10429.3_2 - 3.4e-36 125.4 10.5 1.3e-35 123.5 10.5 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF3498) dNK PF01712.17 MSTRG.13299.2_3 - 3.4e-31 108.6 0.0 4.8e-31 108.1 0.0 1.2 1 0 0 1 1 1 1 Deoxynucleoside kinase Cytidylate_kin PF02224.16 MSTRG.13299.2_3 - 0.023 14.3 0.0 0.039 13.5 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase TsaE PF02367.15 MSTRG.13299.2_3 - 0.055 13.3 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Thymidylate_kin PF02223.15 MSTRG.13299.2_3 - 0.067 12.7 0.2 0.16 11.5 0.2 1.7 1 1 0 1 1 1 0 Thymidylate kinase Pkinase PF00069.23 MSTRG.11128.4_2 - 6e-59 199.4 0.0 6e-59 199.4 0.0 2.8 4 0 0 4 4 4 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.11128.4_2 - 4.5e-28 98.1 0.4 1.9e-27 96.1 0.0 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase Rho_Binding PF08912.9 MSTRG.11128.4_2 - 1.2e-25 89.9 17.2 1.2e-25 89.9 17.2 12.4 4 1 9 14 14 14 1 Rho Binding Pkinase_C PF00433.22 MSTRG.11128.4_2 - 0.0034 17.9 2.1 0.012 16.1 2.1 2.1 1 0 0 1 1 1 1 Protein kinase C terminal domain Cortex-I_coil PF09304.8 MSTRG.11128.4_2 - 0.0044 17.1 7.0 0.0044 17.1 7.0 9.7 4 2 6 10 10 10 1 Cortexillin I, coiled coil APH PF01636.21 MSTRG.11128.4_2 - 0.012 15.4 0.8 0.012 15.4 0.8 3.4 3 2 1 4 4 4 0 Phosphotransferase enzyme family Gla PF00594.18 MSTRG.13534.1_1 - 4.1e-19 68.4 10.6 7.5e-19 67.5 10.6 1.5 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain Shisa PF13908.4 MSTRG.13534.1_1 - 0.0029 17.7 0.0 0.0051 16.9 0.0 1.3 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator TMEM52 PF14979.4 MSTRG.13534.1_1 - 0.023 14.5 3.5 1.1 9.0 3.5 2.6 1 1 0 1 1 1 0 Transmembrane 52 Cadherin_C_2 PF16492.3 MSTRG.13534.1_1 - 0.037 14.7 0.3 0.12 13.0 0.1 2.0 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal FYVE PF01363.19 MSTRG.8503.2_2 - 5.7e-18 64.7 7.9 1.5e-17 63.4 7.9 1.7 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.27 MSTRG.8503.2_2 - 1.5e-09 38.2 0.1 3.3e-09 37.1 0.0 1.6 2 0 0 2 2 2 1 PH domain FYVE_2 PF02318.14 MSTRG.8503.2_2 - 0.0013 18.8 4.1 0.0029 17.7 4.1 1.6 1 0 0 1 1 1 1 FYVE-type zinc finger PH_13 PF16652.3 MSTRG.8503.2_2 - 0.031 14.0 0.7 0.98 9.1 0.7 2.2 1 1 0 1 1 1 0 Pleckstrin homology domain Kelch_1 PF01344.23 MSTRG.10399.2_3 - 1.3e-81 267.8 23.6 1.3e-18 66.1 0.3 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 MSTRG.10399.2_3 - 5.9e-49 162.7 11.9 4.9e-10 39.2 0.2 6.3 1 1 5 6 6 6 6 Kelch motif BACK PF07707.13 MSTRG.10399.2_3 - 3.9e-33 113.5 1.8 3.9e-33 113.5 1.8 1.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_2 PF07646.13 MSTRG.10399.2_3 - 1.4e-31 107.2 11.5 1.9e-06 27.5 0.0 6.4 6 0 0 6 6 6 6 Kelch motif BTB PF00651.29 MSTRG.10399.2_3 - 3.5e-30 104.3 0.2 1e-29 102.8 0.2 1.8 2 0 0 2 2 2 1 BTB/POZ domain Kelch_4 PF13418.4 MSTRG.10399.2_3 - 3.5e-27 94.0 8.8 6e-06 26.0 0.0 6.3 4 1 2 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.4 MSTRG.10399.2_3 - 1.4e-20 72.9 15.2 3e-06 27.2 0.2 5.8 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.4 MSTRG.10399.2_3 - 1.2e-09 37.8 18.3 0.021 14.7 0.0 6.1 6 0 0 6 6 6 4 Kelch motif DUF3342 PF11822.6 MSTRG.10399.2_3 - 3.9e-05 23.6 0.5 0.00028 20.9 0.1 2.4 2 1 1 3 3 3 1 Domain of unknown function (DUF3342) Glu_cyclase_2 PF05096.10 MSTRG.10399.2_3 - 0.0053 16.1 0.0 0.64 9.3 0.0 2.6 1 1 2 3 3 3 3 Glutamine cyclotransferase PQQ_3 PF13570.4 MSTRG.10399.2_3 - 0.054 13.9 8.3 29 5.2 0.1 4.9 5 0 0 5 5 5 0 PQQ-like domain Pkinase PF00069.23 MSTRG.15256.5_1 - 9.1e-08 31.6 0.1 7.2e-07 28.7 0.1 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.15256.5_1 - 2.6e-06 26.8 0.0 3.8e-06 26.2 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase AAA_13 PF13166.4 MSTRG.22549.1_1 - 0.027 13.0 20.2 0.19 10.2 10.3 2.0 1 1 1 2 2 2 0 AAA domain WXG100 PF06013.10 MSTRG.22549.1_1 - 0.045 13.8 1.4 0.045 13.8 1.4 2.5 1 1 1 2 2 2 0 Proteins of 100 residues with WXG Fib_alpha PF08702.8 MSTRG.22549.1_1 - 0.097 12.7 18.6 0.036 14.1 13.2 2.4 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family SlyX PF04102.10 MSTRG.22549.1_1 - 0.099 13.1 20.1 3.9 8.0 0.5 3.8 2 1 0 3 3 3 0 SlyX PKcGMP_CC PF16808.3 MSTRG.22549.1_1 - 0.12 12.2 0.1 0.12 12.2 0.1 4.4 4 1 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase MUG113 PF13455.4 MSTRG.22549.1_1 - 0.13 12.8 2.2 0.65 10.6 1.5 2.2 2 0 0 2 2 2 0 Meiotically up-regulated gene 113 V_ATPase_I PF01496.17 MSTRG.22549.1_1 - 0.15 9.8 16.5 0.18 9.5 16.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family YqzH PF14164.4 MSTRG.22549.1_1 - 0.15 12.0 2.9 0.22 11.5 1.1 2.3 1 1 1 2 2 2 0 YqzH-like protein DUF1759 PF03564.13 MSTRG.22549.1_1 - 0.18 11.6 5.6 0.13 12.1 2.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1759) TPR_7 PF13176.4 MSTRG.22549.1_1 - 0.21 11.6 1.3 0.84 9.7 0.0 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat MAD PF05557.11 MSTRG.22549.1_1 - 0.4 8.8 29.8 0.83 7.8 29.8 1.5 1 1 0 1 1 1 0 Mitotic checkpoint protein Mucin15 PF15672.3 MSTRG.22549.1_1 - 0.63 9.3 5.3 0.87 8.9 4.9 1.3 1 1 0 1 1 1 0 Cell-membrane associated Mucin15 DUF1993 PF09351.8 MSTRG.22549.1_1 - 2.5 8.1 11.1 0.8 9.7 7.5 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF1993) DUF4806 PF16064.3 MSTRG.22549.1_1 - 2.6 8.3 8.8 1.3 9.2 1.3 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4806) DUF948 PF06103.9 MSTRG.22549.1_1 - 4.2 7.6 9.4 8.3 6.6 0.3 3.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) CAF1 PF04857.18 MSTRG.7016.1_2 - 7.2e-88 294.7 0.7 1.3e-44 152.6 0.1 2.2 1 1 1 2 2 2 2 CAF1 family ribonuclease zf-CCCH PF00642.22 MSTRG.7016.1_2 - 0.0029 17.4 0.3 0.0079 16.0 0.3 1.8 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) AIG2_2 PF13772.4 MSTRG.113.1_1 - 3.6e-25 88.0 0.0 1e-24 86.6 0.0 1.8 2 0 0 2 2 2 1 AIG2-like family GGACT PF06094.10 MSTRG.113.1_1 - 1.7e-05 25.2 0.0 2.8e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AT_hook PF02178.17 MSTRG.14984.1_2 - 0.13 12.1 0.8 0.21 11.4 0.8 1.3 1 0 0 1 1 1 0 AT hook motif L_lac_phage_MSP PF06488.9 MSTRG.24231.5_1 - 0.048 12.8 0.2 0.069 12.3 0.2 1.1 1 0 0 1 1 1 0 Phage tail tube protein Tetraspannin PF00335.18 MSTRG.24231.5_2 - 4e-47 160.6 10.1 6.9e-47 159.8 10.1 1.4 1 0 0 1 1 1 1 Tetraspanin family DUF1218 PF06749.10 MSTRG.24231.5_2 - 0.02 15.2 3.4 0.085 13.2 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1218) GpcrRhopsn4 PF10192.7 MSTRG.24231.5_2 - 0.025 13.9 1.1 0.044 13.1 1.1 1.3 1 0 0 1 1 1 0 Rhodopsin-like GPCR transmembrane domain DUF2207 PF09972.7 MSTRG.24231.5_2 - 0.29 9.7 3.0 1.1 7.8 1.7 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Phage_holin_3_6 PF07332.9 MSTRG.24231.5_2 - 3.5 7.6 11.0 1.6 8.7 5.3 2.5 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Arf PF00025.19 MSTRG.4682.1_3 - 3.3e-77 257.7 0.1 4.4e-77 257.3 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 MSTRG.4682.1_3 - 6.6e-14 52.0 0.0 1e-13 51.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 MSTRG.4682.1_3 - 3.7e-13 49.3 0.4 5.8e-13 48.6 0.0 1.5 2 0 0 2 2 2 1 Ras family SRPRB PF09439.8 MSTRG.4682.1_3 - 6.5e-12 45.1 0.0 9.3e-12 44.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 MSTRG.4682.1_3 - 7.4e-11 41.7 0.7 5e-07 29.1 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 MSTRG.4682.1_3 - 2.8e-09 36.6 0.0 3.9e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 MSTRG.4682.1_3 - 0.0017 18.3 0.0 0.0025 17.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.16 MSTRG.4682.1_3 - 0.044 13.0 0.2 0.064 12.4 0.2 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase SpoOE-like PF09388.8 MSTRG.4682.1_3 - 0.12 12.1 1.2 0.23 11.3 1.2 1.4 1 0 0 1 1 1 0 Spo0E like sporulation regulatory protein zf-CCCH PF00642.22 MSTRG.12452.3_1 - 1.3e-07 31.2 19.1 0.0014 18.4 0.9 4.6 4 0 0 4 4 4 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.3 MSTRG.12452.3_1 - 0.013 15.6 0.9 0.013 15.6 0.9 3.3 4 0 0 4 4 4 0 Zinc-finger containing family zf-CCCH_2 PF14608.4 MSTRG.12452.3_1 - 0.045 14.1 29.1 1.2 9.6 1.4 5.5 5 0 0 5 5 5 0 RNA-binding, Nab2-type zinc finger MDM1 PF15501.4 MSTRG.24238.1_2 - 1e-23 84.2 8.4 1e-23 84.2 8.4 2.8 2 1 1 3 3 3 2 Nuclear protein MDM1 FKBP_C PF00254.26 MSTRG.23450.1_2 - 1e-33 115.3 0.0 1.5e-33 114.8 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase G-gamma PF00631.20 MSTRG.4777.1_3 - 3.4e-12 46.1 0.0 4.8e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 GGL domain DUF3338 PF11819.6 MSTRG.6537.1_3 - 3.7e-08 33.3 0.2 8e-08 32.2 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3338) ATP_synth_reg PF14960.4 MSTRG.19048.1_2 - 1e-23 82.4 0.4 1.4e-23 82.0 0.4 1.2 1 0 0 1 1 1 1 ATP synthase regulation Mucin PF01456.15 MSTRG.4409.1_2 - 0.088 12.7 13.0 0.087 12.7 13.0 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein Sigma_reg_N PF13800.4 MSTRG.4409.1_3 - 0.19 11.9 2.0 0.27 11.4 2.0 1.2 1 0 0 1 1 1 0 Sigma factor regulator N-terminal DUF912 PF06024.10 MSTRG.4409.1_3 - 0.5 10.6 3.6 0.56 10.4 3.6 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Sarcoglycan_1 PF04790.11 MSTRG.4409.1_3 - 2.5 7.2 6.7 3 7.0 6.7 1.1 1 0 0 1 1 1 0 Sarcoglycan complex subunit protein Spectrin PF00435.19 MSTRG.26386.2_1 - 5.3e-148 483.2 92.8 1.4e-20 73.6 0.4 9.1 9 0 0 9 9 9 9 Spectrin repeat TadF PF16964.3 MSTRG.26386.2_1 - 0.077 12.6 0.2 17 5.0 0.0 3.2 2 0 0 2 2 2 0 Putative tight adherence pilin protein F NTP_transferase PF00483.21 MSTRG.8402.3_1 - 1.3e-18 67.3 0.0 2.1e-18 66.7 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.5 MSTRG.8402.3_1 - 3.1e-13 50.2 0.0 4.7e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.22 MSTRG.8402.3_1 - 3.3e-06 26.5 4.6 0.2 11.3 1.4 4.0 2 1 3 5 5 5 4 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.3 MSTRG.8402.3_1 - 9.4e-05 20.6 1.6 0.00014 20.0 1.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) IspD PF01128.17 MSTRG.8402.3_1 - 0.037 13.6 0.0 0.067 12.8 0.0 1.4 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase TraI_2 PF07514.9 MSTRG.8402.3_1 - 0.082 11.8 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Putative helicase Fucokinase PF07959.10 MSTRG.8402.3_1 - 0.17 10.8 5.2 0.18 10.7 3.5 1.8 2 1 0 2 2 2 0 L-fucokinase HgmA PF04209.11 MSTRG.370.2_3 - 2.1e-219 728.3 0.1 2.5e-219 728.1 0.1 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase TCRP1 PF14944.4 MSTRG.5620.2_1 - 6e-77 258.8 45.8 2.3e-56 191.4 25.8 2.1 1 1 1 2 2 2 2 Tongue Cancer Chemotherapy Resistant Protein 1 CEP63 PF17045.3 MSTRG.23925.1_2 - 9.7e-44 150.1 50.9 6.9e-40 137.5 19.3 3.2 1 1 2 3 3 3 2 Centrosomal protein of 63 kDa Filament PF00038.19 MSTRG.23925.1_2 - 0.0017 17.9 6.1 0.0017 17.9 6.1 3.3 1 1 2 3 3 3 2 Intermediate filament protein Spc7 PF08317.9 MSTRG.23925.1_2 - 0.057 12.1 43.2 0.046 12.5 15.1 3.2 1 1 2 3 3 3 0 Spc7 kinetochore protein Fez1 PF06818.13 MSTRG.23925.1_2 - 0.099 12.9 43.4 0.78 10.0 18.1 3.1 1 1 2 3 3 3 0 Fez1 Reo_sigmaC PF04582.10 MSTRG.23925.1_2 - 0.94 8.7 9.8 2.3 7.4 2.5 3.1 1 1 2 3 3 3 0 Reovirus sigma C capsid protein Mnd1 PF03962.13 MSTRG.23925.1_2 - 2.8 7.6 39.3 1.2 8.9 12.6 3.2 2 1 1 3 3 3 0 Mnd1 family DUF4200 PF13863.4 MSTRG.23925.1_2 - 3.8 7.8 44.8 0.91 9.8 2.4 4.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) DUF1664 PF07889.10 MSTRG.23925.1_2 - 5.7 6.8 31.0 3.5 7.5 2.7 4.3 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) fn3 PF00041.19 MSTRG.26794.1_2 - 6.1e-14 52.0 4.9 5.7e-08 32.9 0.6 3.2 3 1 0 3 3 3 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 MSTRG.26794.1_2 - 1.2e-05 25.7 0.4 0.14 12.6 0.1 2.6 2 0 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 MSTRG.26794.1_2 - 9.8e-05 22.5 0.1 0.14 12.3 0.0 2.7 2 0 0 2 2 2 2 Interferon-alpha/beta receptor, fibronectin type III LmjF365940-deam PF14421.4 MSTRG.26794.1_2 - 0.12 11.9 0.1 0.23 10.9 0.1 1.4 1 0 0 1 1 1 0 A distinct subfamily of CDD/CDA-like deaminases ELO PF01151.16 MSTRG.24026.2_2 - 2.1e-65 220.6 20.0 2.7e-65 220.2 20.0 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family ADH_N PF08240.10 MSTRG.29078.1_1 - 1.3e-21 76.4 0.1 1.6e-21 76.1 0.1 1.1 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Glyco_trans_4_4 PF13579.4 MSTRG.10211.2_1 - 0.0058 17.0 0.1 0.99 9.7 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase 4-like domain RRM_1 PF00076.20 MSTRG.25897.1_3 - 3.5e-27 93.9 0.3 1.2e-12 47.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 MSTRG.25897.1_3 - 1e-08 34.7 0.2 2.9e-06 26.7 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.21 MSTRG.25897.1_3 - 6.4e-06 25.9 2.8 1.7e-05 24.6 2.8 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.4 MSTRG.25897.1_3 - 0.0046 16.6 4.5 0.0046 16.6 4.5 2.6 2 0 0 2 2 2 1 Zinc knuckle RRM_7 PF16367.3 MSTRG.25897.1_3 - 0.017 15.1 0.0 8.4 6.5 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif DbpA PF03880.13 MSTRG.25897.1_3 - 0.07 13.0 0.1 14 5.6 0.0 2.3 2 0 0 2 2 2 0 DbpA RNA binding domain Amidohydro_1 PF01979.18 MSTRG.24605.3_1 - 1.4e-31 110.0 0.7 1.9e-31 109.5 0.7 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.9 MSTRG.24605.3_1 - 9.6e-12 45.0 0.1 1.6e-05 24.4 0.1 2.6 2 1 1 3 3 3 2 Amidohydrolase family AP_endonuc_2 PF01261.22 MSTRG.24605.3_1 - 0.022 14.0 0.0 0.045 13.0 0.0 1.5 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel Amidohydro_1 PF01979.18 MSTRG.9522.1_3 - 1.9e-22 79.9 0.0 2.4e-22 79.6 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.9 MSTRG.9522.1_3 - 8.2e-08 32.0 0.1 1.8e-07 30.8 0.0 1.5 2 0 0 2 2 2 1 Amidohydrolase family Calsarcin PF05556.9 MSTRG.29352.1_2 - 0.017 14.5 0.1 0.021 14.2 0.1 1.1 1 0 0 1 1 1 0 Calcineurin-binding protein (Calsarcin) Pkinase PF00069.23 MSTRG.4794.3_2 - 1.3e-26 93.5 0.0 1.7e-26 93.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.4794.3_2 - 1.9e-16 60.0 0.0 2.4e-16 59.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 MSTRG.4794.3_2 - 0.002 18.0 0.0 0.0041 17.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF4147 PF13660.4 MSTRG.20989.2_2 - 2.3e-78 262.8 2.7 4.1e-78 261.9 2.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4147) MOFRL PF05161.11 MSTRG.20989.2_2 - 4.1e-34 116.9 0.1 7.9e-34 116.0 0.1 1.5 1 0 0 1 1 1 1 MOFRL family PilM_2 PF11104.6 MSTRG.3324.1_2 - 0.11 11.4 0.0 0.18 10.7 0.0 1.2 1 0 0 1 1 1 0 Type IV pilus assembly protein PilM; Vps26 PF03643.13 MSTRG.25519.1_1 - 6.8e-131 435.1 6.6 8.9e-131 434.8 6.6 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 FCH PF00611.21 MSTRG.10687.1_2 - 3.4e-20 72.0 0.1 6e-17 61.6 0.0 2.6 2 0 0 2 2 2 2 Fes/CIP4, and EFC/F-BAR homology domain Spore_YunB PF09560.8 MSTRG.10687.1_2 - 0.047 13.6 0.3 0.085 12.7 0.3 1.3 1 0 0 1 1 1 0 Sporulation protein YunB (Spo_YunB) Glutaredoxin2_C PF04399.11 MSTRG.10687.1_2 - 0.1 12.3 1.7 0.18 11.5 0.5 2.0 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain Prominin PF05478.9 MSTRG.10687.1_2 - 0.13 10.1 3.6 0.21 9.4 3.6 1.4 1 1 0 1 1 1 0 Prominin SAPIS-gp6 PF16722.3 MSTRG.10687.1_2 - 0.37 11.1 6.0 1.3 9.4 0.2 2.9 2 1 1 3 3 3 0 Pathogenicity island protein gp6 in Staphylococcus ZYG-11_interact PF05884.10 MSTRG.10687.1_2 - 1.1 8.5 3.7 1.4 8.1 1.1 2.0 2 0 0 2 2 2 0 Interactor of ZYG-11 DUF1664 PF07889.10 MSTRG.10687.1_2 - 2 8.3 5.4 17 5.3 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FYVE PF01363.19 MSTRG.15607.1_1 - 3.5e-09 36.5 14.7 9.8e-09 35.1 14.7 1.8 1 0 0 1 1 1 1 FYVE zinc finger GOLD_2 PF13897.4 MSTRG.15607.1_1 - 6.9e-06 26.5 0.1 0.00011 22.6 0.0 2.3 1 1 1 2 2 2 1 Golgi-dynamics membrane-trafficking Spectrin PF00435.19 MSTRG.7861.1_1 - 7e-207 672.4 305.8 3.1e-13 50.0 4.1 34.1 33 1 0 33 33 33 29 Spectrin repeat GAS2 PF02187.15 MSTRG.7861.1_1 - 4.5e-31 106.6 0.3 1.5e-30 105.0 0.3 2.0 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain EF-hand_6 PF13405.4 MSTRG.7861.1_1 - 7e-11 41.0 1.6 0.0004 20.0 0.4 3.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.30 MSTRG.7861.1_1 - 1e-10 40.3 6.3 7.8e-05 21.8 0.7 3.3 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.4 MSTRG.7861.1_1 - 1.3e-10 41.4 0.9 7.7e-10 39.0 0.9 2.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.4 MSTRG.7861.1_1 - 1e-08 34.6 0.4 1.1e-07 31.4 0.2 2.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.7861.1_1 - 4.4e-08 32.2 4.1 2.3e-05 23.6 1.4 2.9 2 0 0 2 2 2 2 EF hand Shugoshin_N PF07558.9 MSTRG.7861.1_1 - 0.12 12.1 5.3 0.077 12.7 1.0 2.8 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region RhoGEF PF00621.18 MSTRG.24302.1_1 - 3.4e-37 128.3 2.7 5.1e-37 127.7 0.8 2.0 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.27 MSTRG.24302.1_1 - 2.3e-21 76.1 0.3 5e-10 39.7 0.2 2.6 2 0 0 2 2 2 2 PH domain FYVE PF01363.19 MSTRG.24302.1_1 - 2.1e-18 66.1 10.7 4.3e-18 65.1 10.7 1.5 1 0 0 1 1 1 1 FYVE zinc finger PH_13 PF16652.3 MSTRG.24302.1_1 - 0.00011 21.9 2.3 0.0069 16.2 1.2 3.0 2 1 0 2 2 2 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.3 MSTRG.24302.1_1 - 0.0015 18.4 0.1 0.0031 17.4 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 MSTRG.24302.1_1 - 0.0045 17.3 6.2 0.25 11.6 2.4 3.5 3 1 0 3 3 3 1 Pleckstrin homology domain PH_8 PF15409.4 MSTRG.24302.1_1 - 0.16 12.1 0.5 0.58 10.3 0.0 2.1 2 1 0 2 2 2 0 Pleckstrin homology domain PH_9 PF15410.4 MSTRG.24302.1_1 - 1.1 9.5 3.6 24 5.2 1.7 3.0 2 1 0 2 2 2 0 Pleckstrin homology domain FYVE_2 PF02318.14 MSTRG.24302.1_1 - 7.2 6.7 19.5 0.061 13.4 10.3 2.0 2 0 0 2 2 2 0 FYVE-type zinc finger Vps4_C PF09336.8 MSTRG.8447.1_1 - 6.1e-29 99.7 0.2 2.4e-28 97.7 0.3 1.9 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA PF00004.27 MSTRG.8447.1_1 - 0.0021 18.3 0.0 0.0035 17.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) CHAT PF12770.5 MSTRG.16652.1_1 - 5.1e-51 173.7 0.0 9.4e-51 172.8 0.0 1.4 1 0 0 1 1 1 1 CHAT domain PUB PF09409.8 MSTRG.16652.1_1 - 0.00067 19.4 0.0 1 9.2 0.0 2.4 2 0 0 2 2 2 2 PUB domain NAD_binding_2 PF03446.13 MSTRG.3438.1_1 - 4.8e-48 163.2 0.2 7.1e-48 162.6 0.2 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.4 MSTRG.3438.1_1 - 2.3e-33 114.9 0.0 4.3e-33 114.0 0.0 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 2-Hacid_dh_C PF02826.17 MSTRG.3438.1_1 - 9.5e-09 34.7 0.0 1.9e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.15 MSTRG.3438.1_1 - 8.8e-08 32.5 0.1 2e-07 31.4 0.0 1.7 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.16 MSTRG.3438.1_1 - 0.0021 18.2 0.0 0.0052 16.9 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain IlvN PF07991.10 MSTRG.3438.1_1 - 0.003 17.0 0.0 0.0054 16.2 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain 3HCDH_N PF02737.16 MSTRG.3438.1_1 - 0.0059 16.4 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ADH_zinc_N PF00107.24 MSTRG.3438.1_1 - 0.049 13.4 0.0 0.96 9.2 0.0 2.5 2 0 0 2 2 2 0 Zinc-binding dehydrogenase Nitro_FeMo-Co PF02579.15 MSTRG.3438.1_1 - 0.1 12.8 0.2 0.67 10.2 0.1 2.2 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor TPR_1 PF00515.26 MSTRG.24976.1_3 - 2.5e-18 64.9 6.5 1.7e-06 27.4 0.7 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.24976.1_3 - 2.4e-16 58.3 7.5 7.4e-06 25.5 0.4 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.24976.1_3 - 2.4e-16 59.7 7.8 1.4e-09 38.0 1.6 2.1 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.24976.1_3 - 8.5e-16 56.7 2.8 7.9e-05 22.4 0.2 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.24976.1_3 - 8.5e-13 47.2 7.8 8.3e-06 25.4 1.0 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.24976.1_3 - 6.7e-11 41.6 6.3 0.00025 20.7 0.7 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.24976.1_3 - 1.9e-06 28.3 1.0 9.1e-05 22.9 0.4 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_4 PF07721.12 MSTRG.24976.1_3 - 8.7e-06 25.8 1.7 0.59 10.8 0.1 3.6 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.24976.1_3 - 1.1e-05 24.8 2.0 0.15 11.6 0.2 4.2 3 2 1 4 4 4 2 TPR repeat TPR_14 PF13428.4 MSTRG.24976.1_3 - 0.00012 22.5 0.8 4.7 8.2 0.2 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat UreE_C PF05194.10 MSTRG.24976.1_3 - 0.00032 21.0 0.5 0.091 13.1 0.1 2.3 1 1 1 2 2 2 2 UreE urease accessory protein, C-terminal domain ANAPC3 PF12895.5 MSTRG.24976.1_3 - 0.01 15.9 5.4 0.18 11.9 2.0 2.7 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TOM20_plant PF06552.10 MSTRG.24976.1_3 - 0.043 13.4 0.5 4 7.0 0.1 2.1 1 1 0 2 2 2 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_17 PF13431.4 MSTRG.24976.1_3 - 0.048 13.9 1.8 6.4 7.3 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Rapsyn_N PF10579.7 MSTRG.24976.1_3 - 0.14 12.2 0.4 1 9.4 0.1 2.3 1 1 2 3 3 3 0 Rapsyn N-terminal myristoylation and linker region TPR_6 PF13174.4 MSTRG.24976.1_3 - 0.21 12.2 1.4 62 4.4 0.0 3.4 2 1 2 4 4 4 0 Tetratricopeptide repeat Kinesin PF00225.21 MSTRG.18838.1_3 - 4.3e-68 229.5 1.5 5.4e-68 229.2 1.5 1.0 1 0 0 1 1 1 1 Kinesin motor domain WD40 PF00400.30 MSTRG.12672.1_3 - 1.8e-27 94.9 9.9 1.5e-06 28.6 0.0 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.12672.1_3 - 4.8e-14 52.3 3.7 1.9e-05 24.7 0.2 4.2 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 MSTRG.12672.1_3 - 0.00029 20.6 0.0 1.4 8.6 0.0 3.1 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.6 MSTRG.12672.1_3 - 0.043 12.3 0.2 0.073 11.5 0.2 1.3 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Ge1_WD40 PF16529.3 MSTRG.12672.1_3 - 0.081 11.7 0.0 0.19 10.6 0.0 1.6 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein SAM_1 PF00536.28 MSTRG.24254.1_1 - 2.7e-08 34.0 0.0 8.2e-08 32.5 0.0 1.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 MSTRG.24254.1_1 - 3.1e-06 27.0 0.0 2.1e-05 24.4 0.0 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 MSTRG.24254.1_1 - 4e-05 23.4 0.0 6.6e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Ste50p-SAM PF09235.8 MSTRG.24254.1_1 - 0.0044 17.1 0.1 0.0085 16.2 0.1 1.4 1 0 0 1 1 1 1 Ste50p, sterile alpha motif Pkinase PF00069.23 MSTRG.18087.1_2 - 4.1e-44 150.8 0.0 4.3e-22 78.6 0.1 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.18087.1_2 - 2.3e-11 43.3 0.0 4.6e-08 32.5 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase RIO1 PF01163.20 MSTRG.18087.1_2 - 0.068 12.6 0.2 0.13 11.7 0.2 1.4 1 0 0 1 1 1 0 RIO1 family DUF2011 PF09428.8 MSTRG.18087.1_2 - 4.5 7.1 10.6 6.4 6.6 1.2 2.3 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF2011) Actin PF00022.17 MSTRG.23226.1_1 - 1.2e-148 494.9 0.0 3.3e-148 493.5 0.0 1.6 1 1 0 1 1 1 1 Actin HELP PF03451.12 MSTRG.27092.1_3 - 1.7e-31 107.7 0.1 3e-31 106.9 0.1 1.4 1 0 0 1 1 1 1 HELP motif WD40 PF00400.30 MSTRG.27092.1_3 - 3.6e-29 100.3 41.3 0.00024 21.7 0.4 11.6 10 2 1 11 11 11 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.27092.1_3 - 2.4e-11 43.6 0.8 0.0013 18.8 0.0 6.4 4 2 4 8 8 8 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 MSTRG.27092.1_3 - 0.023 13.6 0.1 0.096 11.5 0.0 2.1 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.9 MSTRG.27092.1_3 - 0.045 13.5 0.4 0.24 11.1 0.1 2.3 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A LRRNT PF01462.16 MSTRG.20882.2_1 - 4.3e-10 38.9 4.0 4.3e-10 38.9 4.0 1.9 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain PP28 PF10252.7 MSTRG.18695.1_3 - 1e-29 102.7 17.4 1e-29 102.7 17.4 2.5 2 1 0 2 2 2 1 Casein kinase substrate phosphoprotein PP28 DUF3546 PF12066.6 MSTRG.26605.1_3 - 0.01 16.0 0.0 0.016 15.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3546) Peptidase_C48 PF02902.17 MSTRG.884.1_1 - 0.083 12.6 1.0 0.11 12.2 1.0 1.1 1 0 0 1 1 1 0 Ulp1 protease family, C-terminal catalytic domain VIT PF08487.8 MSTRG.28778.1_1 - 1.8e-10 40.9 0.4 2.5e-10 40.5 0.4 1.1 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain Rad60-SLD PF11976.6 MSTRG.27837.1_3 - 2.8e-24 84.6 0.1 3.8e-24 84.2 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.21 MSTRG.27837.1_3 - 1.4e-10 40.6 0.1 2.1e-10 40.1 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin family SRP9-21 PF05486.10 MSTRG.27837.1_3 - 0.18 12.1 0.1 0.28 11.5 0.1 1.3 1 0 0 1 1 1 0 Signal recognition particle 9 kDa protein (SRP9) C2 PF00168.28 MSTRG.1352.2_2 - 0.0001 22.4 0.0 0.00017 21.7 0.0 1.3 1 0 0 1 1 1 1 C2 domain WASH-7_C PF14746.4 MSTRG.1352.2_3 - 0.39 10.3 0.9 0.72 9.4 0.9 1.3 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal PRY PF13765.4 MSTRG.24457.1_3 - 1.2e-11 43.9 0.0 3.2e-11 42.5 0.0 1.8 1 0 0 1 1 1 1 SPRY-associated domain UNC119_bdg PF15435.4 MSTRG.2295.1_2 - 2.3e-110 366.6 0.5 2.9e-110 366.3 0.5 1.1 1 0 0 1 1 1 1 UNC119-binding protein C5orf30 homologue GATA PF00320.25 MSTRG.14034.1_2 - 6.8e-29 99.1 19.3 2.3e-14 52.6 6.3 2.6 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.10 MSTRG.14034.1_2 - 0.00042 19.6 11.0 0.024 14.0 0.6 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.8 MSTRG.14034.1_2 - 0.15 12.1 4.2 6.2 6.9 0.6 2.7 2 0 0 2 2 2 0 Zinc ribbon domain DUF2387 PF09526.8 MSTRG.14034.1_2 - 1.2 9.2 7.7 7.4 6.7 0.7 3.4 1 1 2 3 3 3 0 Probable metal-binding protein (DUF2387) Auto_anti-p27 PF06677.10 MSTRG.14034.1_2 - 3.7 7.7 8.6 4.1 7.5 0.4 2.6 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) NHS PF15273.4 MSTRG.26774.1_3 - 3.7e-10 39.5 59.3 1.5e-06 27.6 11.2 3.2 2 1 1 3 3 3 2 NHS-like HA2 PF04408.21 MSTRG.20932.1_1 - 1.3e-20 73.5 0.1 2.7e-20 72.5 0.1 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.14 MSTRG.20932.1_1 - 5.9e-10 39.1 0.0 1.1e-09 38.3 0.0 1.4 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_19 PF13245.4 MSTRG.20932.1_1 - 0.021 15.0 0.0 0.038 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.4 MSTRG.20932.1_1 - 0.039 13.4 0.0 0.1 12.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.4 MSTRG.20932.1_1 - 0.097 12.8 0.1 0.41 10.8 0.1 2.0 1 1 0 1 1 1 0 AAA domain Tubulin-binding PF00418.17 MSTRG.14703.1_1 - 0.16 11.9 0.1 0.35 10.8 0.1 1.6 1 0 0 1 1 1 0 Tau and MAP protein, tubulin-binding repeat TTL PF03133.13 MSTRG.14703.1_3 - 9.5e-14 51.1 0.0 1.5e-13 50.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.4 MSTRG.14703.1_3 - 0.00018 20.7 0.0 0.00025 20.2 0.0 1.1 1 0 0 1 1 1 1 YheC/D like ATP-grasp Cyt-b5 PF00173.26 MSTRG.17359.6_3 - 4.1e-09 36.3 0.0 6.6e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain SH3-RhoG_link PF16609.3 MSTRG.13363.1_1 - 1.3e-129 431.4 18.8 1.3e-129 431.4 18.8 2.4 3 0 0 3 3 2 1 SH3-RhoGEF linking unstructured region RhoGEF PF00621.18 MSTRG.13363.1_1 - 3.9e-75 251.9 3.4 1e-37 130.0 0.2 2.5 2 0 0 2 2 2 2 RhoGEF domain Pkinase PF00069.23 MSTRG.13363.1_1 - 8e-55 185.9 0.0 1.3e-54 185.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.13363.1_1 - 1.6e-28 99.6 0.0 2.6e-28 98.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase I-set PF07679.14 MSTRG.13363.1_1 - 3.7e-20 71.7 0.0 7e-20 70.8 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.13363.1_1 - 5.1e-14 52.5 0.1 5.1e-14 52.5 0.1 2.2 2 0 0 2 2 1 1 Immunoglobulin domain ig PF00047.23 MSTRG.13363.1_1 - 3.8e-13 49.3 0.2 9e-13 48.1 0.2 1.7 1 0 0 1 1 1 1 Immunoglobulin domain PH PF00169.27 MSTRG.13363.1_1 - 4.6e-13 49.5 0.3 1e-06 29.1 0.2 2.7 2 0 0 2 2 2 2 PH domain SH3_1 PF00018.26 MSTRG.13363.1_1 - 5.8e-11 41.7 0.0 6.4e-06 25.5 0.0 2.6 2 0 0 2 2 2 2 SH3 domain Ig_2 PF13895.4 MSTRG.13363.1_1 - 2.4e-09 37.3 0.2 5.9e-09 36.0 0.2 1.7 1 0 0 1 1 1 1 Immunoglobulin domain PH_10 PF15411.4 MSTRG.13363.1_1 - 1.6e-08 34.7 0.1 0.0036 17.4 0.0 3.1 2 0 0 2 2 2 2 Pleckstrin homology domain SH3_9 PF14604.4 MSTRG.13363.1_1 - 3.3e-06 26.7 0.0 0.034 13.9 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.15 MSTRG.13363.1_1 - 0.0001 21.8 0.0 0.75 9.4 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain IQ_SEC7_PH PF16453.3 MSTRG.13363.1_1 - 0.00015 21.6 0.5 0.035 13.9 0.0 3.2 4 0 0 4 4 4 1 PH domain V-set PF07686.15 MSTRG.13363.1_1 - 0.00029 20.8 0.9 0.012 15.6 0.9 2.8 1 1 0 1 1 1 1 Immunoglobulin V-set domain PH_13 PF16652.3 MSTRG.13363.1_1 - 0.0088 15.8 0.1 0.031 14.0 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain Val_tRNA-synt_C PF10458.7 MSTRG.13363.1_1 - 0.13 12.4 0.0 0.39 10.9 0.0 1.8 1 0 0 1 1 1 0 Valyl tRNA synthetase tRNA binding arm Dopey_N PF04118.12 MSTRG.22954.3_2 - 6.5e-86 288.1 0.7 7.8e-86 287.8 0.7 1.1 1 0 0 1 1 1 1 Dopey, N-terminal I-set PF07679.14 MSTRG.25846.1_3 - 1.9e-13 50.1 0.0 3.6e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.25846.1_3 - 1.7e-10 41.2 0.0 3.8e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 MSTRG.25846.1_3 - 6.3e-08 32.6 0.0 1.4e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.25846.1_3 - 2.4e-05 24.4 0.0 5.2e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 MSTRG.25846.1_3 - 0.0067 16.4 0.3 0.33 11.0 0.3 2.7 1 1 0 1 1 1 1 Immunoglobulin V-set domain ST7 PF04184.10 MSTRG.27013.3_2 - 1.3e-287 954.4 5.8 4e-285 946.2 5.8 2.0 1 1 0 1 1 1 1 ST7 protein TPR_19 PF14559.4 MSTRG.27013.3_2 - 0.00024 21.4 0.1 0.00024 21.4 0.1 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.27013.3_2 - 0.013 16.0 0.2 0.049 14.1 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.27013.3_2 - 0.016 15.1 1.8 2.7 8.2 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.27013.3_2 - 0.04 14.1 0.2 0.12 12.5 0.0 1.8 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.27013.3_2 - 0.057 13.1 0.6 15 5.5 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat MIG-14_Wnt-bd PF06664.10 MSTRG.22671.1_1 - 4.7e-89 298.3 35.0 4.7e-89 298.3 35.0 2.3 3 1 0 3 3 3 1 Wnt-binding factor required for Wnt secretion Dynactin PF12455.6 MSTRG.19922.1_3 - 1.7e-41 142.2 2.3 1.7e-41 142.2 2.3 2.5 2 0 0 2 2 2 1 Dynein associated protein DUF4407 PF14362.4 MSTRG.19922.1_3 - 0.0012 18.2 5.1 0.0022 17.3 1.4 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF4407) Vps39_1 PF10366.7 MSTRG.19922.1_3 - 0.014 15.6 0.3 0.014 15.6 0.3 2.5 3 0 0 3 3 2 0 Vacuolar sorting protein 39 domain 1 DUF4172 PF13776.4 MSTRG.19922.1_3 - 0.036 14.3 0.1 0.29 11.4 0.0 2.6 2 0 0 2 2 1 0 Domain of unknown function (DUF4172) eIF-4B PF06273.9 MSTRG.19922.1_3 - 0.038 12.9 5.5 0.55 9.1 4.3 2.1 2 0 0 2 2 2 0 Plant specific eukaryotic initiation factor 4B Phage_GPO PF05929.9 MSTRG.19922.1_3 - 0.052 13.0 1.5 0.13 11.8 1.5 1.7 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase ATG16 PF08614.9 MSTRG.19922.1_3 - 0.1 12.6 19.2 0.17 11.9 4.4 3.6 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) Baculo_PEP_C PF04513.10 MSTRG.19922.1_3 - 0.1 12.5 2.7 0.34 10.8 0.6 2.9 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus HisKA_3 PF07730.11 MSTRG.19922.1_3 - 0.16 12.4 4.6 1.3 9.5 0.3 3.8 3 0 0 3 3 3 0 Histidine kinase Birna_RdRp PF04197.10 MSTRG.19922.1_3 - 0.26 9.4 5.0 0.29 9.3 3.6 1.6 2 0 0 2 2 2 0 Birnavirus RNA dependent RNA polymerase (VP1) Cob_adeno_trans PF01923.16 MSTRG.19922.1_3 - 0.36 10.8 5.7 0.77 9.7 1.9 3.0 3 0 0 3 3 3 0 Cobalamin adenosyltransferase MCU PF04678.11 MSTRG.19922.1_3 - 0.47 10.4 3.6 2.3 8.2 3.6 2.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter ING PF12998.5 MSTRG.19922.1_3 - 0.75 10.3 7.6 2.4 8.6 7.6 1.9 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding Prefoldin PF02996.15 MSTRG.19922.1_3 - 0.82 9.5 13.7 0.59 9.9 4.6 4.0 2 1 1 3 3 3 0 Prefoldin subunit WXG100 PF06013.10 MSTRG.19922.1_3 - 0.87 9.7 5.1 0.98 9.6 0.8 3.3 2 1 1 3 3 3 0 Proteins of 100 residues with WXG FTCD_C PF04961.10 MSTRG.19922.1_3 - 0.97 9.0 6.5 0.13 11.9 1.7 1.9 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase AAA_13 PF13166.4 MSTRG.19922.1_3 - 1.1 7.8 7.3 1.9 6.9 7.3 1.3 1 0 0 1 1 1 0 AAA domain Fib_alpha PF08702.8 MSTRG.19922.1_3 - 1.3 9.0 6.7 1.4 8.9 4.2 2.4 2 0 0 2 2 1 0 Fibrinogen alpha/beta chain family CREPT PF16566.3 MSTRG.19922.1_3 - 1.5 8.8 13.8 1.4 8.9 1.6 4.1 3 1 1 4 4 4 0 Cell-cycle alteration and expression-elevated protein in tumour DUF948 PF06103.9 MSTRG.19922.1_3 - 1.8 8.7 5.9 6.6 6.9 1.5 3.8 3 3 1 4 4 4 0 Bacterial protein of unknown function (DUF948) ABC_tran_CTD PF16326.3 MSTRG.19922.1_3 - 5.7 7.1 19.7 0.8 9.9 4.7 4.5 2 1 1 3 3 3 0 ABC transporter C-terminal domain DUF342 PF03961.11 MSTRG.19922.1_3 - 6.8 5.0 7.4 18 3.7 7.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF342) IncA PF04156.12 MSTRG.19922.1_3 - 7.7 6.1 22.5 1.3e+02 2.2 18.9 3.7 3 2 0 3 3 3 0 IncA protein HMMR_N PF15905.3 MSTRG.19922.1_3 - 9.2 5.5 21.0 0.076 12.3 10.7 2.6 4 0 0 4 4 3 0 Hyaluronan mediated motility receptor N-terminal APG6 PF04111.10 MSTRG.19922.1_3 - 9.8 5.3 13.3 6.3 6.0 10.8 1.9 2 0 0 2 2 2 0 Autophagy protein Apg6 GAS PF13851.4 MSTRG.17278.1_2 - 4.5e-15 55.4 16.7 5.1e-15 55.3 16.7 1.0 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Takusan PF04822.11 MSTRG.17278.1_2 - 0.0076 16.0 6.6 0.0076 16.0 6.6 1.8 2 0 0 2 2 2 1 Takusan Dynamitin PF04912.12 MSTRG.17278.1_2 - 0.016 14.4 13.0 0.018 14.3 13.0 1.0 1 0 0 1 1 1 0 Dynamitin dCache_1 PF02743.16 MSTRG.17278.1_2 - 0.039 13.6 2.0 0.046 13.4 2.0 1.1 1 0 0 1 1 1 0 Cache domain DUF148 PF02520.15 MSTRG.17278.1_2 - 0.07 13.1 8.2 0.35 10.9 8.1 2.0 1 1 0 1 1 1 0 Domain of unknown function DUF148 CENP-H PF05837.10 MSTRG.17278.1_2 - 0.18 12.1 11.1 0.097 13.0 8.8 1.6 1 1 1 2 2 2 0 Centromere protein H (CENP-H) IncA PF04156.12 MSTRG.17278.1_2 - 0.29 10.8 16.1 0.49 10.0 16.1 1.5 1 1 0 1 1 1 0 IncA protein MAT1 PF06391.11 MSTRG.17278.1_2 - 0.48 10.1 16.8 0.63 9.7 16.8 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Uds1 PF15456.4 MSTRG.17278.1_2 - 0.54 10.3 15.9 0.87 9.6 5.0 2.1 1 1 1 2 2 2 0 Up-regulated During Septation OmpH PF03938.12 MSTRG.17278.1_2 - 0.82 9.5 17.3 0.44 10.4 14.9 1.7 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) TMF_DNA_bd PF12329.6 MSTRG.17278.1_2 - 1.1 9.2 20.9 1.4 8.9 8.8 3.1 2 1 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF4407 PF14362.4 MSTRG.17278.1_2 - 1.1 8.4 9.7 1.4 8.0 9.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1515 PF07439.9 MSTRG.17278.1_2 - 1.3 8.9 6.8 1.7 8.5 6.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1515) HR1 PF02185.14 MSTRG.17278.1_2 - 2.2 8.3 14.8 0.73 9.9 5.1 2.7 1 1 1 2 2 2 0 Hr1 repeat Mnd1 PF03962.13 MSTRG.17278.1_2 - 2.2 8.0 14.6 4.1 7.1 14.6 1.5 1 1 0 1 1 1 0 Mnd1 family DUF972 PF06156.11 MSTRG.17278.1_2 - 2.3 8.8 10.9 11 6.6 10.9 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF972) Prominin PF05478.9 MSTRG.17278.1_2 - 2.8 5.6 8.0 3.1 5.5 8.0 1.1 1 0 0 1 1 1 0 Prominin DivIC PF04977.13 MSTRG.17278.1_2 - 3.1 7.5 15.8 0.73 9.5 7.0 2.8 2 1 1 3 3 3 0 Septum formation initiator DUF3450 PF11932.6 MSTRG.17278.1_2 - 4.9 6.2 16.4 2.1 7.4 5.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF724 PF05266.12 MSTRG.17278.1_2 - 5.7 6.6 17.9 1.1 8.9 12.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Atg14 PF10186.7 MSTRG.17278.1_2 - 9.8 5.0 12.1 13 4.7 12.1 1.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 MACPF PF01823.17 MSTRG.7077.1_3 - 1.8e-07 31.4 0.0 3e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 MAC/Perforin domain Ribosomal_L7Ae PF01248.24 MSTRG.7077.1_3 - 0.062 12.9 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Maf PF02545.12 MSTRG.26546.1_3 - 9.1e-54 181.6 0.0 1.8e-53 180.7 0.0 1.5 1 0 0 1 1 1 1 Maf-like protein Methyltransf_2 PF00891.16 MSTRG.26546.1_3 - 3.3e-51 173.6 0.0 5.6e-51 172.8 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Dimerisation2 PF16864.3 MSTRG.26546.1_3 - 2e-28 98.1 1.1 2e-28 98.1 1.1 2.0 2 0 0 2 2 2 1 Dimerisation domain Methyltransf_25 PF13649.4 MSTRG.26546.1_3 - 0.02 15.4 0.0 0.079 13.6 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain DUF4535 PF15054.4 MSTRG.26321.1_2 - 6.4e-10 38.4 0.4 1.7e-09 37.1 0.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4535) Bacillus_HBL PF05791.9 MSTRG.26321.1_2 - 0.12 12.0 0.3 3.8 7.1 0.0 2.0 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Dak1 PF02733.15 MSTRG.24521.3_1 - 2.6e-05 23.1 0.0 3.3e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.15 MSTRG.24521.3_3 - 1.4e-43 148.7 5.6 2.1e-43 148.1 5.6 1.3 1 0 0 1 1 1 1 DAK2 domain Dak1 PF02733.15 MSTRG.24521.3_3 - 3.2e-21 75.4 0.0 5.1e-21 74.7 0.0 1.3 1 0 0 1 1 1 1 Dak1 domain SNF2_N PF00176.21 MSTRG.8998.3_1 - 2.8e-74 249.8 0.0 1.7e-48 165.0 0.0 2.2 2 0 0 2 2 2 2 SNF2 family N-terminal domain HIRAN PF08797.9 MSTRG.8998.3_1 - 2.5e-17 62.5 0.0 6.2e-17 61.2 0.0 1.7 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.29 MSTRG.8998.3_1 - 1.5e-15 57.4 0.0 4.6e-15 55.8 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.4 MSTRG.8998.3_1 - 6.1e-09 35.5 7.8 1.4e-08 34.3 7.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 MSTRG.8998.3_1 - 5.3e-08 32.5 8.1 1.4e-07 31.1 8.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.8998.3_1 - 8.1e-07 29.1 8.8 2.4e-06 27.6 8.8 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.23 MSTRG.8998.3_1 - 9.4e-07 28.5 8.1 2.3e-06 27.2 8.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.8998.3_1 - 2.4e-06 27.3 5.6 6.5e-06 25.9 5.6 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.4 MSTRG.8998.3_1 - 8.2e-06 25.6 7.4 2.3e-05 24.1 7.4 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.4 MSTRG.8998.3_1 - 0.00011 22.1 8.8 0.00025 21.0 8.8 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.4 MSTRG.8998.3_1 - 0.00018 21.2 8.2 0.0004 20.0 8.2 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.5 MSTRG.8998.3_1 - 0.00034 20.5 0.9 0.00079 19.3 0.9 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.4 MSTRG.8998.3_1 - 0.00064 19.4 4.3 0.0018 17.9 4.3 1.8 1 0 0 1 1 1 1 zf-RING of BARD1-type protein ResIII PF04851.13 MSTRG.8998.3_1 - 0.0015 18.4 0.0 0.24 11.3 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit zf-rbx1 PF12678.5 MSTRG.8998.3_1 - 0.0086 16.2 3.5 0.034 14.3 3.2 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-Nse PF11789.6 MSTRG.8998.3_1 - 0.012 15.3 3.0 0.051 13.3 3.0 2.0 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.4 MSTRG.8998.3_1 - 0.05 13.2 2.6 0.12 12.0 2.6 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.3 MSTRG.8998.3_1 - 1.7 8.3 6.6 5.8 6.6 6.6 2.0 1 0 0 1 1 1 0 RING-like zinc finger JmjC PF02373.20 MSTRG.27948.4_3 - 5.7e-43 145.9 0.1 1.4e-42 144.6 0.1 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.4 MSTRG.27948.4_3 - 3.8e-14 52.7 0.0 1.3e-13 50.9 0.0 2.0 1 0 0 1 1 1 1 PHD-zinc-finger like domain PHD_2 PF13831.4 MSTRG.27948.4_3 - 1.2e-13 50.2 6.6 4.3e-13 48.4 6.6 2.1 1 0 0 1 1 1 1 PHD-finger JmjN PF02375.15 MSTRG.27948.4_3 - 3.7e-13 49.0 0.0 1e-12 47.6 0.0 1.8 1 0 0 1 1 1 1 jmjN domain PHD PF00628.27 MSTRG.27948.4_3 - 1e-05 25.2 4.1 6e-05 22.7 4.1 2.4 1 0 0 1 1 1 1 PHD-finger PHD_4 PF16866.3 MSTRG.27948.4_3 - 4.7 7.3 11.8 2.7 8.0 7.3 3.1 2 0 0 2 2 2 0 PHD-finger DNA_pol_phi PF04931.11 MSTRG.27948.4_3 - 5.5 4.9 8.8 8.6 4.2 8.8 1.2 1 0 0 1 1 1 0 DNA polymerase phi Glyco_transf_29 PF00777.16 MSTRG.66.1_2 - 4.2e-39 134.4 0.0 6.5e-39 133.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Pentaxin PF00354.15 MSTRG.19405.1_2 - 6.6e-31 107.4 0.0 1.1e-30 106.7 0.0 1.3 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.4 MSTRG.19405.1_2 - 2e-13 50.6 0.0 3.1e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF4407 PF14362.4 MSTRG.19405.1_2 - 0.14 11.3 3.9 0.24 10.6 3.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.8 MSTRG.19405.1_2 - 0.15 12.1 4.7 0.48 10.5 0.1 2.9 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family Med9 PF07544.11 MSTRG.19405.1_2 - 0.16 11.9 1.1 0.63 10.0 0.0 2.3 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF2570 PF10828.6 MSTRG.19405.1_2 - 0.65 9.8 4.8 0.13 12.0 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) SlyX PF04102.10 MSTRG.19405.1_2 - 0.81 10.2 9.3 2 9.0 0.2 3.3 3 0 0 3 3 3 0 SlyX DUF16 PF01519.14 MSTRG.19405.1_2 - 2.7 8.4 4.4 3.7 7.9 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF4570 PF15134.4 MSTRG.19405.1_2 - 8.6 6.3 13.0 0.05 13.5 1.2 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4570) GHMP_kinases_N PF00288.24 MSTRG.3081.1_3 - 1e-18 67.1 0.4 2.4e-18 66.0 0.4 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.11 MSTRG.3081.1_3 - 1e-06 28.9 0.0 2.7e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.7 MSTRG.3081.1_3 - 0.075 12.5 0.0 0.18 11.3 0.0 1.6 1 0 0 1 1 1 0 Galactokinase galactose-binding signature Pkinase PF00069.23 MSTRG.3873.2_2 - 1.9e-63 214.2 0.6 3e-63 213.5 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain CNH PF00780.20 MSTRG.3873.2_2 - 1.9e-54 185.0 0.0 2.9e-54 184.4 0.0 1.3 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.15 MSTRG.3873.2_2 - 2.1e-46 158.2 0.0 3.3e-46 157.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Coatomer_WDAD PF04053.12 MSTRG.1686.1_3 - 2.1e-06 27.0 3.8 0.001 18.1 0.0 2.3 2 0 0 2 2 2 2 Coatomer WD associated region Clathrin PF00637.18 MSTRG.1686.1_3 - 0.00018 21.3 8.8 0.00046 19.9 3.5 3.0 2 1 1 3 3 3 1 Region in Clathrin and VPS Fer4_8 PF13183.4 MSTRG.1686.1_3 - 0.0077 16.5 0.6 1 9.7 0.2 3.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain TPR_7 PF13176.4 MSTRG.1686.1_3 - 0.014 15.2 5.3 0.91 9.6 0.4 5.4 4 2 1 5 5 5 0 Tetratricopeptide repeat ArdA PF07275.9 MSTRG.1686.1_3 - 0.014 15.8 1.2 0.08 13.4 0.3 2.5 1 1 1 2 2 2 0 Antirestriction protein (ArdA) DUF1057 PF06342.10 MSTRG.1686.1_3 - 0.044 12.7 0.8 0.071 12.0 0.8 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Prok-RING_4 PF14447.4 MSTRG.1686.1_3 - 0.11 12.2 9.2 0.077 12.7 4.7 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 DUF410 PF04190.11 MSTRG.1686.1_3 - 0.12 12.1 7.9 0.31 10.7 0.0 3.4 2 1 0 3 3 3 0 Protein of unknown function (DUF410) TPR_16 PF13432.4 MSTRG.1686.1_3 - 0.22 12.1 0.1 0.22 12.1 0.1 4.5 4 1 1 5 5 5 0 Tetratricopeptide repeat KRAB PF01352.25 MSTRG.1686.1_3 - 0.23 11.1 2.9 1.8 8.2 0.0 3.5 4 0 0 4 4 4 0 KRAB box Gluconate_2-dh3 PF13618.4 MSTRG.1686.1_3 - 0.32 11.2 1.3 10 6.3 0.1 2.5 2 0 0 2 2 2 0 Gluconate 2-dehydrogenase subunit 3 Cmc1 PF08583.8 MSTRG.1686.1_3 - 0.74 9.7 5.4 2 8.4 1.2 3.1 3 0 0 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like CALCOCO1 PF07888.9 MSTRG.17241.7_2 - 5.1e-77 259.7 69.7 1.7e-76 258.0 35.1 3.2 1 1 0 2 2 2 2 Calcium binding and coiled-coil domain (CALCOCO1) like C1_4 PF07975.10 MSTRG.17241.7_2 - 0.034 14.3 1.9 0.1 12.8 1.9 1.8 1 0 0 1 1 1 0 TFIIH C1-like domain UBZ_FAAP20 PF15750.3 MSTRG.17241.7_2 - 0.2 11.5 3.8 3 7.7 0.6 2.8 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger zf-C2H2_4 PF13894.4 MSTRG.17241.7_2 - 1.1 10.1 9.5 1.5 9.7 0.7 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger EF-hand_7 PF13499.4 MSTRG.6546.1_2 - 1e-18 67.4 3.6 6.1e-11 42.5 0.3 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.6546.1_2 - 1.3e-18 65.1 2.9 2.9e-05 23.5 0.1 4.9 4 1 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.30 MSTRG.6546.1_2 - 2.3e-18 64.2 9.2 5.5e-07 28.6 0.1 4.5 5 0 0 5 5 5 3 EF hand EF-hand_5 PF13202.4 MSTRG.6546.1_2 - 2e-13 49.1 4.4 7.4e-05 22.0 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.4 MSTRG.6546.1_2 - 2.6e-10 39.8 0.9 0.00048 19.7 0.1 3.2 2 1 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.7 MSTRG.6546.1_2 - 0.00072 19.7 2.2 0.044 14.0 0.2 2.6 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region TruD PF01142.16 MSTRG.21628.4_1 - 9.7e-75 251.8 0.0 2.8e-68 230.5 0.0 2.4 2 1 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) Maf_N PF08383.9 MSTRG.21628.4_2 - 0.088 12.5 0.1 0.21 11.3 0.1 1.6 1 0 0 1 1 1 0 Maf N-terminal region EF-hand_1 PF00036.30 MSTRG.539.1_3 - 8.2e-30 100.0 27.5 2.3e-08 32.9 1.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 MSTRG.539.1_3 - 9.6e-28 96.3 10.4 1.1e-14 54.5 5.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.539.1_3 - 3.6e-25 85.6 16.5 8e-08 31.5 0.5 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.4 MSTRG.539.1_3 - 3.2e-23 81.1 21.1 9e-12 44.4 0.4 3.9 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.539.1_3 - 1.2e-19 68.7 22.8 5.6e-07 28.7 1.4 4.5 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.4 MSTRG.539.1_3 - 3.4e-12 46.4 0.7 3.9e-06 26.9 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.7 MSTRG.539.1_3 - 4.2e-06 26.9 0.3 0.0013 19.0 0.3 2.2 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 MSTRG.539.1_3 - 9.1e-05 22.2 9.3 0.086 12.7 0.4 3.5 1 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_11 PF08976.9 MSTRG.539.1_3 - 0.00056 20.6 0.0 0.13 13.0 0.0 2.2 1 1 1 2 2 2 1 EF-hand domain p25-alpha PF05517.10 MSTRG.539.1_3 - 0.0011 19.0 0.6 0.49 10.4 0.1 2.2 1 1 1 2 2 2 2 p25-alpha Phage_TAC_12 PF12363.6 MSTRG.539.1_3 - 0.053 13.8 1.0 2.6 8.3 0.1 2.2 2 0 0 2 2 2 0 Phage tail assembly chaperone protein, TAC DUF4207 PF13904.4 MSTRG.2707.1_2 - 0.0025 17.4 1.0 0.0032 17.1 1.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4207) Amidohydro_1 PF01979.18 MSTRG.5342.1_2 - 2.7e-19 69.5 0.5 4.1e-19 69.0 0.5 1.3 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.9 MSTRG.5342.1_2 - 1.2e-07 31.5 0.1 2.2e-05 24.0 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Not3 PF04065.13 MSTRG.6869.4_3 - 4.9e-97 323.8 27.0 7.9e-97 323.1 27.0 1.3 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.16 MSTRG.6869.4_3 - 1e-26 93.5 5.8 1e-26 93.5 5.8 2.1 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family ZnuA PF01297.15 MSTRG.6869.4_3 - 0.082 12.2 1.5 0.13 11.5 1.5 1.3 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic Syntaxin_2 PF14523.4 MSTRG.6869.4_3 - 1 9.6 12.2 0.44 10.8 1.2 3.1 3 0 0 3 3 3 0 Syntaxin-like protein Exo70 PF03081.13 MSTRG.10181.4_3 - 4.5e-75 252.9 5.0 4.5e-75 252.9 5.0 1.5 2 0 0 2 2 2 1 Exo70 exocyst complex subunit Sec34 PF04136.13 MSTRG.10181.4_3 - 0.012 15.4 1.5 0.054 13.2 1.5 2.2 1 0 0 1 1 1 0 Sec34-like family RolB_RolC PF02027.15 MSTRG.10181.4_3 - 0.083 12.4 0.5 0.21 11.1 0.5 1.8 1 1 0 1 1 1 0 RolB/RolC glucosidase family IZUMO PF15005.4 MSTRG.10181.4_3 - 0.27 11.6 3.9 4 7.8 0.1 3.7 4 0 0 4 4 4 0 Izumo sperm-egg fusion, Ig domain-associated Atg14 PF10186.7 MSTRG.10181.4_3 - 0.53 9.2 8.2 2.1 7.2 1.5 2.3 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Exonuc_VII_L PF02601.13 MSTRG.10181.4_3 - 2.7 7.3 5.1 0.92 8.9 0.2 2.3 2 0 0 2 2 2 0 Exonuclease VII, large subunit C1-set PF07654.13 MSTRG.18673.2_2 - 2.3e-44 149.6 0.4 5.4e-14 52.3 0.0 4.7 5 0 0 5 5 5 4 Immunoglobulin C1-set domain Ig_3 PF13927.4 MSTRG.18673.2_2 - 1.5e-19 70.3 3.7 7.7e-07 29.5 0.0 5.8 5 1 0 5 5 5 3 Immunoglobulin domain V-set PF07686.15 MSTRG.18673.2_2 - 7.3e-15 54.9 2.7 4.8e-13 49.1 0.1 4.2 4 1 0 4 4 4 1 Immunoglobulin V-set domain C2-set_2 PF08205.10 MSTRG.18673.2_2 - 8.8e-11 41.6 2.3 0.021 14.8 0.0 4.7 5 0 0 5 5 5 3 CD80-like C2-set immunoglobulin domain I-set PF07679.14 MSTRG.18673.2_2 - 8.9e-11 41.6 0.3 8.9e-05 22.4 0.0 4.3 5 1 0 5 5 5 2 Immunoglobulin I-set domain ig PF00047.23 MSTRG.18673.2_2 - 1.2e-10 41.2 11.7 1.8e-06 27.9 0.1 6.0 5 2 0 5 5 5 3 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.18673.2_2 - 1.9e-06 28.0 6.3 0.0056 16.9 0.2 5.5 5 2 0 5 5 5 1 Immunoglobulin domain Marek_A PF02124.13 MSTRG.18673.2_2 - 5.6e-05 22.9 0.4 0.15 11.7 0.0 2.3 2 0 0 2 2 2 2 Marek's disease glycoprotein A LIM PF00412.20 MSTRG.22872.5_1 - 0.37 10.9 13.5 0.83 9.8 13.5 1.6 1 0 0 1 1 1 0 LIM domain zf-H2C2_2 PF13465.4 MSTRG.16105.1_3 - 3.8e-109 352.5 105.1 1.2e-09 38.1 1.6 15.9 16 0 0 16 16 15 14 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.16105.1_3 - 9.3e-74 239.9 111.8 6.3e-06 26.2 0.9 16.5 16 0 0 16 16 16 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.16105.1_3 - 3.2e-51 167.4 107.9 0.00043 20.7 0.3 16.5 16 0 0 16 16 16 15 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.16105.1_3 - 5.3e-29 99.5 93.5 1.1e-05 25.1 1.5 16.6 16 1 0 16 16 16 12 C2H2-type zinc finger zf-met PF12874.5 MSTRG.16105.1_3 - 1.2e-25 89.0 91.5 0.0054 16.9 0.6 15.5 16 0 0 16 16 15 11 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.16105.1_3 - 1.2e-14 54.1 44.8 0.012 15.8 0.1 13.8 13 1 1 14 14 14 4 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 MSTRG.16105.1_3 - 1.9e-11 43.9 65.4 0.012 15.7 2.5 9.0 6 1 5 11 11 10 8 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.3 MSTRG.16105.1_3 - 7.1e-11 41.5 72.1 0.0057 16.3 0.5 14.6 15 0 0 15 15 15 7 zinc-finger C2H2-type BolA PF01722.16 MSTRG.16105.1_3 - 1.4e-06 28.4 23.0 0.48 10.6 0.2 7.7 2 1 2 5 5 5 3 BolA-like protein zf-C2H2_2 PF12756.5 MSTRG.16105.1_3 - 0.00015 21.9 57.3 0.64 10.2 5.5 13.0 1 1 12 13 13 13 2 C2H2 type zinc-finger (2 copies) zinc_ribbon_15 PF17032.3 MSTRG.16105.1_3 - 0.00044 20.8 48.6 0.49 11.1 0.4 8.3 3 2 9 12 12 11 6 zinc-ribbon family DUF2180 PF09947.7 MSTRG.16105.1_3 - 0.00091 19.0 32.3 4.6 7.2 0.3 9.9 3 2 8 12 12 12 2 Uncharacterized protein conserved in archaea (DUF2180) LIM PF00412.20 MSTRG.16105.1_3 - 0.0037 17.3 60.6 0.67 10.1 1.1 11.2 2 1 11 13 13 13 2 LIM domain Zn-ribbon_8 PF09723.8 MSTRG.16105.1_3 - 0.024 14.6 57.1 0.08 12.9 2.0 10.0 5 1 7 12 12 12 0 Zinc ribbon domain DUF2256 PF10013.7 MSTRG.16105.1_3 - 0.12 12.3 61.1 1.9 8.6 0.6 14.5 15 0 0 15 15 15 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2HE PF16278.3 MSTRG.16105.1_3 - 0.12 12.7 75.6 2.9 8.3 1.0 14.5 1 1 12 13 13 13 0 C2HE / C2H2 / C2HC zinc-binding finger C1_2 PF03107.14 MSTRG.16105.1_3 - 0.74 10.0 70.8 37 4.6 0.7 15.5 3 2 11 15 15 15 0 C1 domain HypA PF01155.17 MSTRG.16105.1_3 - 3.2 7.7 48.9 6.4 6.7 2.2 8.7 1 1 5 6 6 5 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FEZ PF07763.11 MSTRG.8304.2_2 - 1.9e-106 355.0 8.4 2.5e-106 354.7 8.4 1.1 1 0 0 1 1 1 1 FEZ-like protein DUF5102 PF17104.3 MSTRG.8304.2_2 - 0.00046 20.2 0.8 0.084 12.8 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF5102) Clathrin_bdg PF15045.4 MSTRG.8304.2_2 - 0.12 12.2 0.3 0.3 10.9 0.3 1.7 1 0 0 1 1 1 0 Clathrin-binding box of Aftiphilin, vesicle trafficking Vert_IL3-reg_TF PF06529.9 MSTRG.2319.1_3 - 1.3e-73 247.9 18.6 2e-73 247.3 18.6 1.2 1 0 0 1 1 1 1 Vertebrate interleukin-3 regulated transcription factor bZIP_2 PF07716.13 MSTRG.2319.1_3 - 1.1e-14 54.1 9.7 2.6e-14 52.9 9.7 1.7 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.19 MSTRG.2319.1_3 - 1.4e-05 25.0 5.6 1.4e-05 25.0 5.6 1.9 2 0 0 2 2 2 1 bZIP transcription factor bZIP_Maf PF03131.15 MSTRG.2319.1_3 - 0.0082 16.5 2.8 0.02 15.3 2.8 1.6 1 0 0 1 1 1 1 bZIP Maf transcription factor HLH PF00010.24 MSTRG.17317.2_3 - 6.5e-10 38.7 1.3 6.5e-10 38.7 1.3 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Cas_Csy4 PF09618.8 MSTRG.17317.2_3 - 0.093 12.8 0.3 0.73 9.8 0.0 2.1 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csy4) RP-C_C PF11800.6 MSTRG.17317.2_3 - 0.17 11.8 1.4 0.3 11.0 1.4 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region CDC45 PF02724.12 MSTRG.17317.2_3 - 0.42 8.7 5.1 0.59 8.2 5.1 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF1495 PF07381.9 MSTRG.16628.1_2 - 0.098 12.4 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain (DUF1495) Dimerisation PF08100.9 MSTRG.16628.1_3 - 0.075 12.9 0.8 0.64 9.9 0.1 2.1 2 0 0 2 2 2 0 Dimerisation domain DUF5082 PF16888.3 MSTRG.7479.1_1 - 0.1 12.8 0.1 0.17 12.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) SSP160 PF06933.9 MSTRG.7479.1_1 - 0.11 10.5 4.7 0.16 10.0 4.7 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 CARD PF00619.19 MSTRG.7479.1_3 - 0.00013 21.8 0.1 0.00034 20.5 0.1 1.6 1 0 0 1 1 1 1 Caspase recruitment domain SIX1_SD PF16878.3 MSTRG.7518.1_2 - 5.6e-48 161.9 0.3 6.8e-47 158.4 0.1 2.2 2 0 0 2 2 2 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeobox PF00046.27 MSTRG.7518.1_2 - 3e-13 49.2 0.9 8.9e-13 47.7 0.9 1.8 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 MSTRG.7518.1_2 - 4e-09 36.1 2.7 6.4e-09 35.4 0.8 2.2 2 0 0 2 2 2 1 Homeobox KN domain zf-C2H2_2 PF12756.5 MSTRG.516.1_3 - 1.1e-07 32.0 27.1 0.027 14.6 1.0 5.2 3 2 2 5 5 5 4 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.4 MSTRG.516.1_3 - 1.3e-07 31.6 31.6 0.2 12.5 0.4 6.3 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2 PF00096.24 MSTRG.516.1_3 - 1.9e-05 24.7 35.2 0.024 15.0 0.2 6.5 6 0 0 6 6 6 3 Zinc finger, C2H2 type zf-met PF12874.5 MSTRG.516.1_3 - 0.0018 18.5 14.6 0.027 14.7 0.4 3.7 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.516.1_3 - 0.059 13.6 0.2 0.059 13.6 0.2 4.2 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 MSTRG.516.1_3 - 0.64 10.1 11.9 6.8 6.8 0.1 5.3 5 0 0 5 5 5 0 Zinc ribbon domain zf-C2H2_6 PF13912.4 MSTRG.516.1_3 - 0.89 9.4 31.7 0.077 12.8 0.3 5.5 5 0 0 5 5 5 0 C2H2-type zinc finger DUF678 PF05077.10 MSTRG.516.1_3 - 2 8.5 7.4 19 5.3 0.2 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF678) TLD PF07534.14 MSTRG.24609.2_2 - 4.5e-40 137.0 0.3 8.7e-40 136.0 0.3 1.5 1 0 0 1 1 1 1 TLD LysM PF01476.18 MSTRG.24609.2_2 - 1.3e-07 31.5 0.0 2.6e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 LysM domain GRAM PF02893.18 MSTRG.24609.2_2 - 0.0015 18.2 0.1 0.0055 16.4 0.0 1.9 2 0 0 2 2 2 1 GRAM domain AKAP2_C PF15304.4 MSTRG.19547.1_3 - 0.00097 18.4 8.9 0.0027 16.9 8.9 1.9 1 1 0 1 1 1 1 A-kinase anchor protein 2 C-terminus Kunitz_BPTI PF00014.21 MSTRG.19391.4_3 - 1.3e-28 98.8 16.8 6e-20 71.1 3.9 2.4 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Trypsin PF00089.24 MSTRG.15448.2_1 - 4.4e-59 199.8 0.5 6.5e-59 199.3 0.5 1.3 1 0 0 1 1 1 1 Trypsin Kringle PF00051.16 MSTRG.15448.2_1 - 4e-21 75.0 3.5 1.2e-20 73.4 3.5 1.9 1 0 0 1 1 1 1 Kringle domain EGF PF00008.25 MSTRG.15448.2_1 - 3.7e-08 33.4 45.4 0.00014 22.0 10.4 5.4 5 0 0 5 5 5 3 EGF-like domain Trypsin_2 PF13365.4 MSTRG.15448.2_1 - 8.6e-06 26.6 0.1 2.1e-05 25.3 0.1 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain TGF_beta PF00019.18 MSTRG.8165.1_2 - 7.4e-22 78.1 0.3 1.6e-21 77.0 0.3 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain TACI-CRD2 PF09305.8 MSTRG.14346.1_3 - 0.39 10.7 3.3 1.5 8.8 2.4 2.0 2 0 0 2 2 2 0 TACI, cysteine-rich domain CTP_transf_like PF01467.24 MSTRG.18260.1_3 - 2.3e-08 34.2 0.0 3.3e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like Cofilin_ADF PF00241.18 MSTRG.10087.1_3 - 2.1e-12 47.2 0.0 2.8e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Collagen PF01391.16 MSTRG.10774.1_3 - 4.1e-11 42.4 35.4 5.6e-11 41.9 35.4 1.2 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) zf-C2H2 PF00096.24 MSTRG.21950.2_3 - 5.3e-71 231.2 219.9 0.00056 20.1 2.7 28.3 27 1 1 28 28 28 25 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.21950.2_3 - 4e-57 185.8 211.2 0.0011 19.5 0.4 28.4 28 0 0 28 28 28 24 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.21950.2_3 - 4.7e-40 135.0 139.1 7.1e-05 22.9 1.2 24.3 23 1 1 24 24 24 16 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.4 MSTRG.21950.2_3 - 4.8e-21 74.1 203.5 2.6e-06 27.5 0.7 27.8 32 0 0 32 32 32 17 Zinc-finger double domain zf-met PF12874.5 MSTRG.21950.2_3 - 2.1e-19 69.1 170.0 0.006 16.8 1.2 24.3 24 1 1 25 25 25 14 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 MSTRG.21950.2_3 - 4.3e-17 61.5 210.8 7.3e-06 25.7 0.9 26.2 26 2 0 26 26 26 16 C2H2-type zinc finger ADK_lid PF05191.12 MSTRG.21950.2_3 - 0.0083 16.0 0.0 0.0083 16.0 0.0 15.0 16 2 1 17 17 17 2 Adenylate kinase, active site lid BolA PF01722.16 MSTRG.21950.2_3 - 0.012 15.8 20.8 0.096 12.9 0.5 6.6 6 0 0 6 6 6 0 BolA-like protein zf-C2HE PF16278.3 MSTRG.21950.2_3 - 0.047 14.0 0.0 0.047 14.0 0.0 17.4 12 8 7 19 19 19 0 C2HE / C2H2 / C2HC zinc-binding finger Borealin PF10512.7 MSTRG.24299.4_3 - 0.0023 17.8 0.3 0.0029 17.4 0.3 1.1 1 0 0 1 1 1 1 Cell division cycle-associated protein 8 Myc_N PF01056.16 MSTRG.13316.1_3 - 9.7e-100 334.5 14.8 3.5e-99 332.7 14.8 1.9 1 1 0 1 1 1 1 Myc amino-terminal region HLH PF00010.24 MSTRG.13316.1_3 - 6.5e-11 41.9 1.2 1.5e-10 40.7 1.2 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Myc-LZ PF02344.13 MSTRG.13316.1_3 - 6.2e-06 26.1 8.2 2e-05 24.4 8.2 1.9 1 0 0 1 1 1 1 Myc leucine zipper domain SPX PF03105.17 MSTRG.13316.1_3 - 0.6 9.9 7.7 1 9.1 7.7 1.3 1 0 0 1 1 1 0 SPX domain CENP-B_dimeris PF09026.8 MSTRG.13316.1_3 - 4.9 7.5 15.6 12 6.2 15.6 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Astro_capsid_p PF12226.6 MSTRG.13316.1_3 - 6.6 5.6 7.3 11 4.9 7.3 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Carn_acyltransf PF00755.18 MSTRG.8499.1_2 - 1.8e-190 634.3 0.0 2.1e-190 634.1 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase PH PF00169.27 MSTRG.25131.2_1 - 0.0068 16.8 0.0 0.018 15.4 0.0 1.7 1 0 0 1 1 1 1 PH domain Sushi PF00084.18 MSTRG.6954.1_3 - 2.9e-17 62.9 4.6 1.3e-08 35.2 0.1 2.5 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) CUB PF00431.18 MSTRG.6954.1_3 - 5.6e-15 55.5 0.0 9e-15 54.8 0.0 1.3 1 0 0 1 1 1 1 CUB domain Trypsin PF00089.24 MSTRG.6954.1_3 - 7.4e-09 35.6 0.0 1.2e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 Trypsin HRM PF02793.20 MSTRG.6954.1_3 - 0.0014 18.8 2.6 0.25 11.5 0.2 3.5 3 0 0 3 3 3 2 Hormone receptor domain Tmemb_cc2 PF10267.7 MSTRG.24644.1_3 - 5.7e-62 210.0 4.7 7.3e-62 209.6 4.7 1.1 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein Exonuc_VII_L PF02601.13 MSTRG.24644.1_3 - 0.013 14.9 3.4 0.019 14.4 3.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Fer4_19 PF06902.9 MSTRG.24644.1_3 - 0.076 13.0 0.0 0.21 11.6 0.0 1.7 1 0 0 1 1 1 0 Divergent 4Fe-4S mono-cluster OmpH PF03938.12 MSTRG.24644.1_3 - 0.21 11.4 8.8 0.32 10.8 8.8 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Uds1 PF15456.4 MSTRG.24644.1_3 - 2.1 8.4 9.6 3.5 7.7 9.6 1.3 1 0 0 1 1 1 0 Up-regulated During Septation SlyX PF04102.10 MSTRG.24644.1_3 - 2.1 8.9 7.2 9.5 6.8 0.7 2.6 2 0 0 2 2 2 0 SlyX Mnd1 PF03962.13 MSTRG.24644.1_3 - 2.2 8.0 8.1 3.5 7.3 8.1 1.2 1 0 0 1 1 1 0 Mnd1 family NfeD PF01957.16 MSTRG.21444.1_1 - 0.74 10.1 1.7 1.2 9.4 1.7 1.2 1 0 0 1 1 1 0 NfeD-like C-terminal, partner-binding Arm PF00514.21 MSTRG.21444.1_2 - 2.8e-41 138.2 19.2 1.3e-07 31.3 0.1 11.9 13 0 0 13 13 13 7 Armadillo/beta-catenin-like repeat Cnd1 PF12717.5 MSTRG.21444.1_2 - 1.5e-08 34.7 1.8 0.0052 16.7 0.3 4.3 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.4 MSTRG.21444.1_2 - 3.2e-06 27.3 4.9 0.039 14.2 0.2 4.9 5 0 0 5 5 5 1 HEAT repeats HEAT_EZ PF13513.4 MSTRG.21444.1_2 - 6.1e-06 26.4 7.0 1.6 9.2 0.0 6.1 5 1 1 6 6 6 2 HEAT-like repeat HEAT PF02985.20 MSTRG.21444.1_2 - 7.8e-06 25.6 1.5 24 5.4 0.0 5.8 5 0 0 5 5 5 0 HEAT repeat Adaptin_N PF01602.18 MSTRG.21444.1_2 - 7.9e-06 24.6 2.7 0.0014 17.2 1.1 3.0 3 0 0 3 3 3 1 Adaptin N terminal region KAP PF05804.10 MSTRG.21444.1_2 - 0.00045 18.4 1.2 0.052 11.5 0.0 3.1 1 1 1 3 3 3 1 Kinesin-associated protein (KAP) DUF3361 PF11841.6 MSTRG.21444.1_2 - 0.0017 18.2 1.4 2.7 7.8 0.0 4.4 2 1 2 4 4 4 1 Domain of unknown function (DUF3361) Atx10homo_assoc PF09759.7 MSTRG.21444.1_2 - 0.0024 17.8 0.9 0.032 14.2 0.1 3.2 3 1 1 4 4 4 1 Spinocerebellar ataxia type 10 protein domain Queuosine_synth PF02547.13 MSTRG.21444.1_2 - 0.031 13.3 0.5 0.057 12.4 0.1 1.5 2 0 0 2 2 2 0 Queuosine biosynthesis protein Arm_2 PF04826.11 MSTRG.21444.1_2 - 0.045 13.1 3.6 0.98 8.7 0.0 3.3 2 1 1 3 3 3 0 Armadillo-like RasGEF_N_2 PF14663.4 MSTRG.21444.1_2 - 0.068 13.4 8.9 7.6 6.8 0.0 5.0 5 1 0 5 5 5 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Phosphorylase PF00343.18 MSTRG.25900.5_3 - 1.2e-153 512.9 1.1 1.4e-153 512.7 1.1 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase FeThRed_B PF02943.13 MSTRG.25900.5_3 - 0.026 14.4 0.9 0.078 12.8 0.9 1.8 1 0 0 1 1 1 0 Ferredoxin thioredoxin reductase catalytic beta chain DUF2115 PF09888.7 MSTRG.25900.5_3 - 0.19 12.1 1.4 0.6 10.5 1.4 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) zf-C2H2_4 PF13894.4 MSTRG.18978.2_1 - 4.8e-11 42.4 30.8 0.042 14.5 0.8 5.6 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_2 PF12756.5 MSTRG.18978.2_1 - 0.0004 20.5 5.5 7.6 6.8 0.0 5.0 5 0 0 5 5 5 2 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.24 MSTRG.18978.2_1 - 0.026 14.8 0.1 0.026 14.8 0.1 6.1 5 1 0 5 5 5 0 Zinc finger, C2H2 type zf-FCS PF06467.12 MSTRG.18978.2_1 - 0.36 10.7 9.4 1.9 8.4 0.2 4.0 4 0 0 4 4 4 0 MYM-type Zinc finger with FCS sequence motif PyrI_C PF02748.13 MSTRG.18978.2_1 - 3.2 7.6 5.5 8.5 6.2 0.2 2.9 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DUF2256 PF10013.7 MSTRG.18978.2_1 - 3.3 7.8 10.8 8.9 6.4 0.0 4.2 5 0 0 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2H2_jaz PF12171.6 MSTRG.18978.2_1 - 6 7.2 17.0 7.6 6.8 0.1 4.8 4 1 0 4 4 4 0 Zinc-finger double-stranded RNA-binding DUF4603 PF15376.4 MSTRG.24472.1_1 - 0 2168.3 26.7 0 2168.1 26.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4603) FAM117 PF15388.4 MSTRG.12620.2_1 - 3.6e-95 318.7 8.2 3.6e-95 318.7 8.2 2.0 2 0 0 2 2 2 1 Protein Family FAM117 SID-1_RNA_chan PF13965.4 MSTRG.21236.1_1 - 2.4e-278 924.6 17.4 3.2e-278 924.2 17.4 1.2 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 DUF1582 PF07621.9 MSTRG.24004.2_1 - 0.026 14.3 1.4 0.037 13.8 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1582) COesterase PF00135.26 MSTRG.16782.1_1 - 6.1e-34 117.7 0.0 6.8e-34 117.5 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family DENN PF02141.19 MSTRG.21634.1_2 - 2.3e-49 167.7 0.4 3.2e-49 167.3 0.4 1.2 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.17 MSTRG.21634.1_2 - 2.8e-08 33.5 2.9 8e-08 32.0 2.9 1.8 1 0 0 1 1 1 1 dDENN domain SPA PF08616.8 MSTRG.21634.1_2 - 0.014 15.2 0.1 0.023 14.5 0.1 1.3 1 0 0 1 1 1 0 Stabilization of polarity axis CCT_2 PF09425.8 MSTRG.21634.1_2 - 0.33 10.7 1.6 12 5.7 0.2 2.8 2 0 0 2 2 2 0 Divergent CCT motif Asparaginase PF00710.18 MSTRG.4681.1_1 - 3.1e-64 215.9 0.0 5.4e-64 215.1 0.0 1.4 1 0 0 1 1 1 1 Asparaginase, N-terminal Ank_2 PF12796.5 MSTRG.4681.1_1 - 2e-14 53.8 0.3 5.4e-13 49.2 0.1 2.7 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.4681.1_1 - 4.1e-12 46.2 0.2 1.7e-08 34.7 0.0 4.3 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.4681.1_1 - 4.8e-09 36.1 0.1 2.2e-05 24.6 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.4 MSTRG.4681.1_1 - 1.4e-06 28.0 0.2 0.0012 19.0 0.0 4.3 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.4 MSTRG.4681.1_1 - 4.5e-06 26.7 0.4 0.00028 21.0 0.1 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) RhoGAP PF00620.25 MSTRG.14420.1_2 - 6.6e-32 110.3 0.1 1.2e-31 109.4 0.1 1.4 1 0 0 1 1 1 1 RhoGAP domain DUF1708 PF08101.9 MSTRG.14420.1_2 - 0.055 12.5 0.0 0.089 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1708) Penicillinase_R PF03965.14 MSTRG.14420.1_2 - 0.17 12.1 0.1 0.37 11.0 0.1 1.5 1 0 0 1 1 1 0 Penicillinase repressor FAD_binding_7 PF03441.12 MSTRG.5536.1_1 - 4.5e-69 231.7 0.7 6.7e-69 231.1 0.7 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.16 MSTRG.5536.1_1 - 2e-41 141.6 0.0 4.4e-41 140.5 0.0 1.5 2 0 0 2 2 2 1 DNA photolyase CUE PF02845.14 MSTRG.16481.2_2 - 2e-09 36.8 0.1 3.8e-09 35.9 0.1 1.5 1 0 0 1 1 1 1 CUE domain zf-RanBP PF00641.16 MSTRG.16481.2_2 - 0.00066 18.8 1.6 0.0028 16.8 1.6 2.1 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others DASH_Spc34 PF08657.8 MSTRG.16481.2_2 - 0.62 9.7 3.2 1 9.0 3.2 1.2 1 0 0 1 1 1 0 DASH complex subunit Spc34 Cyclin_C PF02984.17 MSTRG.4297.2_1 - 0.0091 15.9 0.0 0.021 14.8 0.0 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain Cyclin_N PF00134.21 MSTRG.4297.2_1 - 0.081 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Cyclin, N-terminal domain Cyclin_N PF00134.21 MSTRG.4297.2_2 - 1.2e-09 37.9 0.0 1.5e-07 31.1 0.0 2.2 2 0 0 2 2 2 2 Cyclin, N-terminal domain GDI PF00996.16 MSTRG.5109.1_1 - 1e-233 775.4 0.2 1.2e-233 775.2 0.2 1.1 1 0 0 1 1 1 1 GDP dissociation inhibitor Amino_oxidase PF01593.22 MSTRG.5109.1_1 - 0.017 14.3 0.0 0.023 13.8 0.0 1.1 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase XK-related PF09815.7 MSTRG.5048.1_1 - 5.3e-62 209.7 18.1 9e-62 208.9 18.1 1.3 1 0 0 1 1 1 1 XK-related protein Pox_A14 PF05767.10 MSTRG.5048.1_1 - 0.018 15.1 0.2 0.055 13.5 0.2 1.9 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 PRA1 PF03208.17 MSTRG.5048.1_1 - 0.51 9.8 10.3 0.25 10.9 7.0 2.2 2 1 0 2 2 2 0 PRA1 family protein DUF3886 PF13025.4 MSTRG.24577.2_1 - 0.0029 17.6 0.8 0.056 13.5 2.2 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3886) zf-CCHC_3 PF13917.4 MSTRG.24577.2_2 - 0.02 14.7 0.6 0.02 14.7 0.6 2.4 2 0 0 2 2 2 0 Zinc knuckle NYAP_C PF15452.4 MSTRG.618.1_2 - 1.9e-13 50.7 0.5 1.9e-13 50.7 0.5 2.2 2 0 0 2 2 2 1 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter Pkinase PF00069.23 MSTRG.5239.1_2 - 8.9e-28 97.2 0.1 1.2e-27 96.8 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.5239.1_2 - 3.7e-14 52.5 0.2 4.8e-14 52.1 0.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PL48 PF15903.3 MSTRG.19674.4_1 - 7.4e-06 25.0 0.3 1.2e-05 24.4 0.3 1.3 1 0 0 1 1 1 1 Filopodia upregulated, FAM65 Spc97_Spc98 PF04130.11 MSTRG.12488.3_1 - 3.4e-120 402.2 2.9 3.4e-120 402.2 2.9 1.5 2 0 0 2 2 2 1 Spc97 / Spc98 family Fib_alpha PF08702.8 MSTRG.12488.3_1 - 0.23 11.5 3.4 0.57 10.2 3.4 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family HLH PF00010.24 MSTRG.5559.1_1 - 9.5e-11 41.4 1.7 1.5e-10 40.8 0.8 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain PDZ PF00595.22 MSTRG.24883.1_3 - 3.9e-12 46.2 2.9 7.9e-12 45.2 2.9 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) SAM_2 PF07647.15 MSTRG.24883.1_3 - 2.7e-11 43.3 0.1 5.1e-11 42.4 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 MSTRG.24883.1_3 - 1.3e-09 38.2 0.2 2.9e-09 37.1 0.2 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) TAFH PF07531.12 MSTRG.1709.1_3 - 1.2e-32 111.7 0.3 2.2e-32 110.8 0.3 1.5 1 0 0 1 1 1 1 NHR1 homology to TAF PIEZO PF15917.3 MSTRG.29650.1_1 - 1.2e-54 185.1 1.1 1.8e-54 184.5 1.1 1.3 1 0 0 1 1 1 1 Piezo Chordopox_A33R PF05966.10 MSTRG.29650.1_1 - 0.067 12.3 0.1 0.088 11.9 0.1 1.1 1 0 0 1 1 1 0 Chordopoxvirus A33R protein DUF3487 PF11990.6 MSTRG.29650.1_1 - 0.78 9.5 6.3 0.13 12.0 2.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) V_ATPase_I PF01496.17 MSTRG.5242.2_2 - 0 1118.9 0.0 0 1118.7 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Occludin_ELL PF07303.11 MSTRG.5242.2_2 - 1.2 9.8 3.6 77 3.9 0.3 3.6 4 0 0 4 4 4 0 Occludin homology domain MFS_1 PF07690.14 MSTRG.3069.1_3 - 1.4e-05 24.1 11.3 1.5e-05 24.0 11.3 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.22 MSTRG.3069.1_3 - 3.7e-05 22.6 5.5 3.9e-05 22.6 5.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Methyltransf_23 PF13489.4 MSTRG.24587.1_2 - 2.3e-17 63.2 0.0 3.5e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 MSTRG.24587.1_2 - 2.3e-16 60.1 0.1 4.8e-16 59.0 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 MSTRG.24587.1_2 - 2e-11 44.3 0.1 4.3e-11 43.3 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 MSTRG.24587.1_2 - 2.2e-10 41.0 0.0 4.3e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 MSTRG.24587.1_2 - 9.1e-08 31.9 0.0 1.5e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.18 MSTRG.24587.1_2 - 0.00017 20.9 0.1 0.00063 19.0 0.0 1.9 2 1 0 2 2 2 1 Mycolic acid cyclopropane synthetase NodS PF05401.9 MSTRG.24587.1_2 - 0.039 13.4 0.0 0.092 12.2 0.0 1.5 1 1 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_9 PF08003.9 MSTRG.24587.1_2 - 0.11 11.3 0.0 0.2 10.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Ig_3 PF13927.4 MSTRG.5482.1_1 - 1.8e-13 50.7 0.0 1.6e-07 31.7 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 MSTRG.5482.1_1 - 4.9e-11 42.4 0.1 1.8e-10 40.7 0.0 1.9 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 MSTRG.5482.1_1 - 3.1e-10 40.0 0.0 0.00086 19.3 0.0 3.0 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.5482.1_1 - 1.9e-09 37.6 0.0 8.5e-07 29.1 0.0 3.0 2 1 0 2 2 2 1 Immunoglobulin domain C1-set PF07654.13 MSTRG.5482.1_1 - 2e-07 31.2 0.0 1.5e-06 28.4 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin C1-set domain V-set PF07686.15 MSTRG.5482.1_1 - 2.2e-06 27.6 0.0 1.2e-05 25.3 0.0 2.1 2 1 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.14 MSTRG.5482.1_1 - 3.1e-06 27.0 0.0 0.023 14.6 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin I-set domain DUF4381 PF14316.4 MSTRG.5482.1_1 - 0.008 16.3 0.0 0.02 15.0 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4381) LYRIC PF15686.3 MSTRG.5482.1_1 - 0.016 14.6 0.4 0.024 14.1 0.4 1.1 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family FAM176 PF14851.4 MSTRG.5482.1_1 - 0.043 13.4 0.3 0.076 12.6 0.3 1.3 1 0 0 1 1 1 0 FAM176 family V-set_CD47 PF08204.9 MSTRG.5482.1_1 - 0.14 12.1 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain AIG1 PF04548.14 MSTRG.21783.1_2 - 0.0011 18.2 0.0 0.0014 17.8 0.0 1.1 1 0 0 1 1 1 1 AIG1 family Pkinase_C PF00433.22 MSTRG.716.1_3 - 4.4e-07 30.4 0.8 8.8e-07 29.4 0.8 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain Copine PF07002.14 MSTRG.11726.4_2 - 3e-87 291.5 0.0 4.6e-87 290.9 0.0 1.3 1 0 0 1 1 1 1 Copine C2 PF00168.28 MSTRG.11726.4_2 - 1.6e-28 98.8 0.1 2.9e-13 49.9 0.1 2.4 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.7 MSTRG.11726.4_2 - 3.7e-05 23.8 0.0 7e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus DNA_pol_A_exo1 PF01612.18 MSTRG.8850.4_3 - 5e-16 58.8 0.0 8.2e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 3'-5' exonuclease Ribosomal_S14 PF00253.19 MSTRG.8850.4_3 - 0.0036 16.9 0.1 0.079 12.6 0.0 2.5 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e RRXRR PF14239.4 MSTRG.8850.4_3 - 0.06 13.1 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 RRXRR protein Torsin PF06309.9 MSTRG.16197.1_2 - 2.5e-36 124.4 0.0 4.6e-36 123.6 0.0 1.4 1 0 0 1 1 1 1 Torsin AAA PF00004.27 MSTRG.16197.1_2 - 9.5e-05 22.7 0.0 0.00017 21.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 MSTRG.16197.1_2 - 0.00031 20.9 0.0 0.0078 16.4 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 MSTRG.16197.1_2 - 0.03 14.6 0.2 0.22 11.8 0.2 2.3 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.12 MSTRG.16197.1_2 - 0.12 12.3 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF2059 PF09832.7 MSTRG.26424.1_2 - 0.029 14.3 0.0 0.048 13.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2059) Sugar_tr PF00083.22 MSTRG.26392.2_3 - 1e-17 64.0 10.1 2.2e-12 46.4 8.7 2.3 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.14 MSTRG.26392.2_3 - 1.7e-11 43.5 18.6 2.8e-11 42.8 18.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF2754 PF10953.6 MSTRG.26392.2_3 - 0.4 10.8 5.8 7.8 6.7 0.9 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2754) DUF1856 PF08983.8 MSTRG.22902.1_1 - 0.061 13.5 0.1 0.12 12.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1856) AA_permease PF00324.19 MSTRG.22902.1_2 - 9.1e-23 80.4 9.7 3e-21 75.4 3.0 2.0 2 0 0 2 2 2 2 Amino acid permease DUF4349 PF14257.4 MSTRG.22902.1_2 - 0.024 14.0 0.2 0.051 12.9 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) V-set PF07686.15 MSTRG.9862.1_3 - 1.9e-10 40.7 0.0 3e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 MSTRG.9862.1_3 - 0.001 19.5 0.0 0.0019 18.6 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 MSTRG.9862.1_3 - 0.014 15.5 0.0 0.029 14.4 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.9862.1_3 - 0.075 13.3 0.0 0.29 11.4 0.0 1.9 1 1 0 1 1 1 0 Immunoglobulin domain I-set PF07679.14 MSTRG.9862.1_3 - 0.16 11.9 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain RasGEF PF00617.17 MSTRG.5087.1_1 - 2.5e-49 167.7 0.4 4.7e-49 166.7 0.4 1.5 1 0 0 1 1 1 1 RasGEF domain DEP PF00610.19 MSTRG.5087.1_1 - 2.6e-10 40.1 0.1 8.3e-10 38.5 0.1 1.9 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RasGEF_N PF00618.18 MSTRG.5087.1_1 - 8.7e-10 38.7 0.1 2.1e-09 37.4 0.1 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif NAD_binding_10 PF13460.4 MSTRG.21198.1_2 - 3.2e-37 128.1 0.0 3.8e-37 127.9 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.11 MSTRG.21198.1_2 - 5.3e-10 39.1 0.0 1.1e-09 38.0 0.0 1.5 2 0 0 2 2 2 1 NmrA-like family Epimerase PF01370.19 MSTRG.21198.1_2 - 6.4e-09 35.5 0.0 8.5e-09 35.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.17 MSTRG.21198.1_2 - 1.3e-05 24.2 0.0 1.8e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family PEMT PF04191.11 MSTRG.3516.1_3 - 1.5e-29 102.4 4.3 1.5e-29 102.4 4.3 2.1 2 0 0 2 2 2 1 Phospholipid methyltransferase B9-C2 PF07162.9 MSTRG.14181.1_1 - 1.1e-60 204.6 0.2 1.3e-60 204.3 0.2 1.1 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein Shugoshin_C PF07557.9 MSTRG.11595.1_3 - 2.1e-11 43.2 0.7 8.4e-11 41.3 0.7 2.1 1 0 0 1 1 1 1 Shugoshin C terminus An_peroxidase PF03098.13 MSTRG.12022.1_2 - 4.8e-46 157.3 0.0 9.3e-40 136.5 0.0 2.3 1 1 1 2 2 2 2 Animal haem peroxidase EGF PF00008.25 MSTRG.12022.1_2 - 0.00025 21.1 11.9 0.00025 21.1 11.9 2.9 4 0 0 4 4 4 1 EGF-like domain BPL_N PF09825.7 MSTRG.12022.1_3 - 0.17 10.8 0.0 0.24 10.3 0.0 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Sushi PF00084.18 MSTRG.23728.1_2 - 4.7e-24 84.6 30.3 4.9e-10 39.8 2.6 4.1 3 1 0 3 3 3 3 Sushi repeat (SCR repeat) Lectin_C PF00059.19 MSTRG.23728.1_2 - 2.5e-20 73.1 5.6 2.5e-20 73.1 5.6 2.3 2 0 0 2 2 2 1 Lectin C-type domain EGF PF00008.25 MSTRG.23728.1_2 - 0.016 15.4 4.7 0.016 15.4 4.7 3.5 3 1 1 4 4 4 0 EGF-like domain EGF_2 PF07974.11 MSTRG.23728.1_2 - 0.023 14.9 9.4 0.13 12.6 9.4 2.4 1 0 0 1 1 1 0 EGF-like domain Evr1_Alr PF04777.11 MSTRG.23531.2_2 - 4.9e-24 84.6 0.0 1.1e-23 83.5 0.0 1.6 1 0 0 1 1 1 1 Erv1 / Alr family Thioredoxin PF00085.18 MSTRG.23531.2_2 - 7.7e-20 70.7 0.0 2.6e-18 65.7 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.4 MSTRG.23531.2_2 - 5.9e-05 23.3 0.0 0.0037 17.5 0.0 2.5 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.4 MSTRG.23531.2_2 - 0.0083 16.3 0.0 0.027 14.6 0.0 2.0 1 0 0 1 1 1 1 Thioredoxin-like DUF3453 PF11935.6 MSTRG.729.1_2 - 1.2e-58 198.3 0.6 7e-58 195.8 0.5 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3453) HEAT PF02985.20 MSTRG.729.1_2 - 0.00089 19.2 0.0 7.1 7.0 0.0 4.7 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.4 MSTRG.729.1_2 - 0.0011 19.2 0.1 2 8.7 0.0 4.1 2 2 1 3 3 3 1 HEAT repeats Cnd1 PF12717.5 MSTRG.729.1_2 - 0.0035 17.2 7.4 1.1 9.1 1.9 4.0 2 2 2 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Cohesin_HEAT PF12765.5 MSTRG.729.1_2 - 0.028 14.5 0.0 0.13 12.4 0.0 2.2 1 0 0 1 1 1 0 HEAT repeat associated with sister chromatid cohesion V-ATPase_H_C PF11698.6 MSTRG.729.1_2 - 0.03 14.3 2.0 0.51 10.3 1.1 2.9 2 0 0 2 2 2 0 V-ATPase subunit H Zip PF02535.20 MSTRG.3878.1_1 - 0.8 8.7 6.8 1.2 8.1 6.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter IRS PF02174.15 MSTRG.3878.1_2 - 3.6e-29 100.5 0.0 6.4e-29 99.6 0.0 1.4 1 0 0 1 1 1 1 PTB domain (IRS-1 type) PH PF00169.27 MSTRG.3878.1_2 - 3.6e-09 36.9 0.2 8.2e-09 35.8 0.2 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 MSTRG.3878.1_2 - 0.0002 21.6 0.3 0.0002 21.6 0.3 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.4 MSTRG.3878.1_2 - 0.06 13.5 0.2 0.15 12.2 0.2 1.7 1 1 0 1 1 1 0 Pleckstrin homology domain MIOX PF05153.13 MSTRG.2430.1_1 - 5.8e-118 392.8 3.2 7.5e-118 392.4 3.2 1.1 1 0 0 1 1 1 1 Myo-inositol oxygenase NOT2_3_5 PF04153.16 MSTRG.22142.1_3 - 2.1e-30 105.4 0.3 4.3e-30 104.4 0.3 1.6 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family zf-C4 PF00105.16 MSTRG.12627.1_1 - 1.7e-30 105.2 15.3 3.6e-30 104.1 15.3 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 MSTRG.12627.1_1 - 1.5e-22 80.1 0.1 3.1e-22 79.0 0.1 1.6 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Miga PF10265.7 MSTRG.12627.1_1 - 1.6 7.5 11.8 2.4 6.9 11.8 1.2 1 0 0 1 1 1 0 Mitoguardin SOG2 PF10428.7 MSTRG.12627.1_1 - 4.3 6.3 23.6 8.5 5.4 23.6 1.4 1 0 0 1 1 1 0 RAM signalling pathway protein Ribosomal_L11_N PF03946.12 MSTRG.5947.1_2 - 5.2e-26 90.1 0.1 8.2e-26 89.4 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.17 MSTRG.5947.1_2 - 1.1e-16 61.0 0.2 1.7e-16 60.4 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain zf-C2H2 PF00096.24 MSTRG.20529.2_2 - 5.2e-07 29.6 19.6 0.079 13.3 3.1 4.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.20529.2_2 - 0.037 14.4 0.1 0.037 14.4 0.1 6.4 6 0 0 6 6 6 0 Zinc-finger double domain zf-met PF12874.5 MSTRG.20529.2_2 - 0.19 12.0 7.3 1.5 9.1 0.2 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-FPG_IleRS PF06827.12 MSTRG.20529.2_2 - 0.66 9.7 6.8 0.14 11.9 1.0 2.7 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS zf-C2H2_6 PF13912.4 MSTRG.20529.2_2 - 3.2 7.7 14.3 0.76 9.7 0.4 4.0 3 0 0 3 3 3 0 C2H2-type zinc finger Cullin PF00888.20 MSTRG.29291.1_2 - 3.8e-60 204.0 6.9 4.5e-60 203.8 6.9 1.0 1 0 0 1 1 1 1 Cullin family Thioredoxin_6 PF13848.4 MSTRG.29291.1_2 - 0.0084 16.0 0.3 0.011 15.6 0.3 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain AsnC_trans_reg PF01037.19 MSTRG.29291.1_2 - 0.019 14.8 0.0 0.053 13.4 0.0 1.7 2 0 0 2 2 2 0 Lrp/AsnC ligand binding domain PCMT PF01135.17 MSTRG.19978.2_3 - 1e-82 276.8 0.0 1.4e-82 276.4 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.4 MSTRG.19978.2_3 - 7.8e-07 29.6 0.0 1.4e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 MSTRG.19978.2_3 - 1.5e-06 28.0 0.0 3.3e-06 26.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.11 MSTRG.19978.2_3 - 3.3e-05 23.3 0.0 4.7e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) GCD14 PF08704.8 MSTRG.19978.2_3 - 5.1e-05 22.9 0.0 7.6e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_11 PF08241.10 MSTRG.19978.2_3 - 0.00085 19.8 0.0 0.0017 18.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.16 MSTRG.19978.2_3 - 0.0059 15.8 0.0 0.0096 15.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.7 MSTRG.19978.2_3 - 0.013 15.1 0.0 0.022 14.4 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase MTS PF05175.12 MSTRG.19978.2_3 - 0.042 13.3 0.0 0.071 12.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_23 PF13489.4 MSTRG.19978.2_3 - 0.05 13.4 0.0 0.1 12.4 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain EGF_CA PF07645.13 MSTRG.283.2_1 - 7.4e-06 25.9 8.2 7.4e-06 25.9 8.2 2.9 3 0 0 3 3 3 1 Calcium-binding EGF domain EGF_3 PF12947.5 MSTRG.283.2_1 - 0.0021 18.1 5.3 0.0021 18.1 5.3 3.6 2 2 1 3 3 3 1 EGF domain EGF PF00008.25 MSTRG.283.2_1 - 0.021 15.0 5.7 0.021 15.0 5.7 2.9 3 0 0 3 3 3 0 EGF-like domain GAIN PF16489.3 MSTRG.283.2_1 - 0.04 13.2 0.0 0.055 12.8 0.0 1.2 1 0 0 1 1 1 0 GPCR-Autoproteolysis INducing (GAIN) domain FXa_inhibition PF14670.4 MSTRG.283.2_1 - 4.3 7.6 24.8 0.23 11.6 4.0 2.9 2 1 0 2 2 2 0 Coagulation Factor Xa inhibitory site DUF4976 PF16347.3 MSTRG.19099.2_2 - 2.3e-10 40.5 1.4 4.5e-09 36.3 0.2 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4976) Sulfatase_C PF14707.4 MSTRG.19099.2_2 - 0.01 16.4 0.1 0.014 16.0 0.1 1.4 1 1 0 1 1 1 0 C-terminal region of aryl-sulfatase Hid1 PF12722.5 MSTRG.12916.1_3 - 1.7e-47 162.0 0.1 2e-47 161.8 0.1 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.7 MSTRG.12916.1_3 - 4e-34 118.0 0.0 4.7e-34 117.7 0.0 1.1 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Peptidase_M14 PF00246.22 MSTRG.15474.1_2 - 4.2e-18 66.0 0.0 4.5e-18 65.9 0.0 1.0 1 0 0 1 1 1 1 Zinc carboxypeptidase zf-H2C2_2 PF13465.4 MSTRG.10396.4_2 - 2.3e-24 84.6 39.3 9e-08 32.1 0.1 7.4 7 0 0 7 7 7 5 Zinc-finger double domain zf-H2C2_5 PF13909.4 MSTRG.10396.4_2 - 7.6e-18 63.8 42.0 0.00014 21.4 0.4 6.7 6 0 0 6 6 6 5 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 MSTRG.10396.4_2 - 1.1e-10 41.2 53.3 0.0013 18.9 1.6 6.9 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.10396.4_2 - 4.3e-08 33.2 52.1 0.027 15.2 3.5 6.9 6 0 0 6 6 6 4 C2H2-type zinc finger zf-met PF12874.5 MSTRG.10396.4_2 - 0.013 15.7 0.9 0.013 15.7 0.9 4.8 4 0 0 4 4 4 0 Zinc-finger of C2H2 type Vps39_2 PF10367.7 MSTRG.10396.4_2 - 1.1 9.6 6.6 0.84 10.0 0.4 2.6 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 zf-C2H2_7 PF15269.4 MSTRG.10396.4_2 - 3.1 7.8 20.5 9.1 6.3 1.4 5.4 2 1 3 5 5 5 0 Zinc-finger zf-C2H2_2 PF12756.5 MSTRG.10396.4_2 - 6.8 7.0 25.0 3.8 7.8 0.5 5.5 2 1 1 4 4 4 0 C2H2 type zinc-finger (2 copies) PPDFL PF15060.4 MSTRG.4436.1_2 - 2.4e-41 140.6 3.3 9.7e-41 138.6 3.3 2.0 1 1 0 1 1 1 1 Differentiation and proliferation regulator MHC_I PF00129.16 MSTRG.16139.1_1 - 1.2e-43 148.6 1.9 1.6e-43 148.2 1.9 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 MSTRG.16139.1_1 - 7.8e-10 39.0 0.0 5.8e-09 36.2 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.3 MSTRG.16139.1_1 - 0.0038 16.6 0.0 0.0058 16.0 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain Ig_3 PF13927.4 MSTRG.16139.1_1 - 0.0067 16.9 0.3 0.046 14.2 0.0 2.5 3 0 0 3 3 3 1 Immunoglobulin domain EphA2_TM PF14575.4 MSTRG.16139.1_1 - 0.025 15.3 0.1 0.062 14.0 0.1 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Marek_A PF02124.13 MSTRG.16139.1_1 - 0.032 13.9 0.1 0.048 13.4 0.1 1.2 1 0 0 1 1 1 0 Marek's disease glycoprotein A ig PF00047.23 MSTRG.16139.1_1 - 0.04 14.0 0.0 0.19 11.8 0.0 2.2 2 0 0 2 2 2 0 Immunoglobulin domain TMEM154 PF15102.4 MSTRG.16139.1_1 - 0.045 13.5 0.6 0.087 12.6 0.6 1.4 1 0 0 1 1 1 0 TMEM154 protein family DUF1191 PF06697.10 MSTRG.16139.1_1 - 0.045 12.9 0.4 0.07 12.2 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) DUF4448 PF14610.4 MSTRG.16139.1_1 - 0.071 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF4083 PF13314.4 MSTRG.16139.1_1 - 0.072 12.9 1.3 0.13 12.1 1.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) ECSCR PF15820.3 MSTRG.16139.1_1 - 0.073 12.8 0.4 0.14 11.9 0.4 1.4 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator DUF912 PF06024.10 MSTRG.16139.1_1 - 0.081 13.1 0.3 0.19 11.9 0.3 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF3357 PF11837.6 MSTRG.16139.1_1 - 0.15 12.4 0.2 0.28 11.5 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) UPF0258 PF06789.10 MSTRG.16139.1_1 - 0.26 11.4 5.0 0.46 10.6 5.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0258) Spectrin PF00435.19 MSTRG.633.1_2 - 0.0019 18.5 0.0 1.4 9.4 0.0 2.6 2 0 0 2 2 2 2 Spectrin repeat PAS_4 PF08448.8 MSTRG.633.1_2 - 0.0052 16.9 1.7 0.066 13.3 0.1 2.7 3 1 0 3 3 3 1 PAS fold MCD PF05292.9 MSTRG.25895.1_3 - 2.4e-37 128.7 0.0 2.6e-37 128.6 0.0 1.0 1 0 0 1 1 1 1 Malonyl-CoA decarboxylase (MCD) Peptidase_S9 PF00326.19 MSTRG.23472.1_2 - 5.1e-12 45.6 0.0 7.8e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.16 MSTRG.23472.1_2 - 0.064 12.7 0.0 0.09 12.2 0.0 1.1 1 0 0 1 1 1 0 Dienelactone hydrolase family KH_1 PF00013.27 MSTRG.14887.1_3 - 2.2e-56 187.4 7.4 7.3e-15 54.4 0.1 4.4 4 0 0 4 4 4 4 KH domain KH_2 PF07650.15 MSTRG.14887.1_3 - 8.1e-17 60.7 3.9 0.001 18.7 0.1 4.7 4 0 0 4 4 4 4 KH domain KH_4 PF13083.4 MSTRG.14887.1_3 - 5.2e-15 54.9 0.1 0.0011 18.7 0.0 4.8 4 0 0 4 4 4 3 KH domain KH_5 PF13184.4 MSTRG.14887.1_3 - 7.4e-07 29.0 5.1 0.33 11.0 0.1 4.3 4 0 0 4 4 4 3 NusA-like KH domain MOEP19 PF16005.3 MSTRG.14887.1_3 - 0.00025 20.9 0.1 3.4 7.6 0.0 4.2 4 0 0 4 4 4 1 KH-like RNA-binding domain RRM_1 PF00076.20 MSTRG.14887.1_3 - 0.0013 18.3 0.0 0.0026 17.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 MSTRG.14887.1_3 - 0.28 11.1 0.1 0.28 11.1 0.1 3.2 3 0 0 3 3 3 0 RNA binding motif ArfGap PF01412.16 MSTRG.17667.2_2 - 8.6e-34 115.9 0.3 2e-33 114.7 0.0 1.8 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Ank_2 PF12796.5 MSTRG.17667.2_2 - 2.7e-16 59.8 6.1 3.9e-09 36.8 0.4 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) SH3_9 PF14604.4 MSTRG.17667.2_2 - 1.8e-09 37.2 0.0 3.3e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.17667.2_2 - 9.1e-08 31.4 0.1 2.1e-07 30.3 0.1 1.6 1 0 0 1 1 1 1 SH3 domain Ank PF00023.28 MSTRG.17667.2_2 - 1.1e-07 31.9 1.4 0.00064 19.9 0.1 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.4 MSTRG.17667.2_2 - 3.1e-07 30.7 0.5 1.3e-05 25.5 0.4 3.0 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.4 MSTRG.17667.2_2 - 1.7e-06 28.1 0.1 4.8e-05 23.5 0.1 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.17667.2_2 - 3.6e-06 26.8 0.5 0.18 12.3 0.0 4.0 3 0 0 3 3 3 2 Ankyrin repeat SH3_2 PF07653.15 MSTRG.17667.2_2 - 1.2e-05 24.8 0.0 2.4e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.27 MSTRG.17667.2_2 - 2.5e-05 24.6 0.1 6.3e-05 23.3 0.1 1.7 1 0 0 1 1 1 1 PH domain V-set PF07686.15 MSTRG.8988.4_1 - 2.5e-12 46.8 0.0 3.2e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.14 MSTRG.8988.4_1 - 0.00061 19.7 0.0 0.00093 19.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.8988.4_1 - 0.00087 19.7 0.0 0.0016 18.9 0.0 1.4 1 1 0 1 1 1 1 Immunoglobulin domain DUF3787 PF12655.5 MSTRG.25792.4_1 - 0.039 13.7 0.9 4.2 7.2 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3787) AAA_21 PF13304.4 MSTRG.25792.4_3 - 5.3e-08 32.9 0.0 1.1e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran PF00005.25 MSTRG.25792.4_3 - 0.00018 21.9 0.0 0.00032 21.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter DUF4162 PF13732.4 MSTRG.25792.4_3 - 0.045 14.4 0.0 0.077 13.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4162) OLF PF02191.14 MSTRG.23732.2_2 - 1.3e-81 273.7 7.0 1.5e-81 273.5 7.0 1.0 1 0 0 1 1 1 1 Olfactomedin-like domain zf-H2C2_2 PF13465.4 MSTRG.20085.2_1 - 3.1e-35 118.9 97.5 6.6e-10 38.8 1.6 11.9 12 0 0 12 12 12 6 Zinc-finger double domain zf-H2C2_5 PF13909.4 MSTRG.20085.2_1 - 4.6e-28 96.5 78.9 6.7e-08 32.0 5.8 8.6 8 0 0 8 8 8 8 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 MSTRG.20085.2_1 - 1e-16 60.2 94.9 0.0045 17.3 5.1 9.9 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.20085.2_1 - 0.071 13.8 94.9 0.19 12.5 3.5 10.9 11 0 0 11 11 11 0 C2H2-type zinc finger GAGA PF09237.9 MSTRG.20085.2_1 - 2.8 7.7 32.9 0.13 12.0 0.4 6.8 2 2 4 6 6 6 0 GAGA factor Asp-B-Hydro_N PF05279.9 MSTRG.6781.3_2 - 1.3e-39 136.6 40.7 1.3e-39 136.6 40.7 3.2 1 1 2 3 3 3 1 Aspartyl beta-hydroxylase N-terminal region EF-hand_7 PF13499.4 MSTRG.6781.3_2 - 0.0026 18.1 1.0 0.0098 16.2 1.0 2.0 1 0 0 1 1 1 1 EF-hand domain pair PDZ PF00595.22 MSTRG.13052.1_1 - 1.8e-30 105.0 3.5 4e-16 59.0 0.2 2.4 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.13052.1_1 - 1.7e-13 50.6 0.2 2.7e-05 24.3 0.0 2.5 2 0 0 2 2 2 2 PDZ domain zf-C3HC4_2 PF13923.4 MSTRG.13052.1_1 - 9.3e-09 34.9 8.8 9.3e-09 34.9 8.8 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 MSTRG.13052.1_1 - 1.2e-07 31.3 7.5 5.4e-07 29.2 7.5 2.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 MSTRG.13052.1_1 - 9.8e-06 25.2 8.4 3e-05 23.6 8.4 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.4 MSTRG.13052.1_1 - 2.4e-05 24.4 8.5 2.4e-05 24.4 8.5 2.8 2 1 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.4 MSTRG.13052.1_1 - 3e-05 23.6 6.1 3e-05 23.6 6.1 2.8 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.13052.1_1 - 4e-05 23.4 10.1 4e-05 23.4 10.1 2.5 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 MSTRG.13052.1_1 - 6.8e-05 22.8 8.5 0.00024 21.0 8.5 2.1 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.4 MSTRG.13052.1_1 - 0.00014 21.6 7.1 0.00014 21.6 7.1 2.5 2 0 0 2 2 1 1 zinc-RING finger domain Sina PF03145.14 MSTRG.13052.1_1 - 0.0012 18.7 2.1 0.0012 18.7 2.1 2.4 1 1 1 2 2 2 1 Seven in absentia protein family zf-TRAF PF02176.16 MSTRG.13052.1_1 - 0.0026 18.3 9.7 0.022 15.3 2.5 3.2 1 1 1 2 2 2 2 TRAF-type zinc finger zf-rbx1 PF12678.5 MSTRG.13052.1_1 - 0.009 16.2 5.2 0.038 14.1 5.2 2.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain Tricorn_PDZ PF14685.4 MSTRG.13052.1_1 - 0.032 14.1 0.3 0.15 12.0 0.1 2.1 2 0 0 2 2 2 0 Tricorn protease PDZ domain zf-RING_6 PF14835.4 MSTRG.13052.1_1 - 4.8 7.0 11.3 0.11 12.2 3.9 2.1 2 0 0 2 2 1 0 zf-RING of BARD1-type protein MARVEL PF01284.21 MSTRG.5180.3_2 - 1.1e-09 38.4 4.7 1.1e-09 38.4 4.7 2.0 3 0 0 3 3 3 1 Membrane-associating domain PDE6_gamma PF04868.10 MSTRG.5180.3_2 - 0.071 13.2 2.0 0.13 12.3 2.0 1.4 1 0 0 1 1 1 0 Retinal cGMP phosphodiesterase, gamma subunit MARVEL PF01284.21 MSTRG.5180.3_3 - 2.5e-14 53.4 1.1 2.5e-14 53.4 1.1 2.1 2 0 0 2 2 2 1 Membrane-associating domain FAM27 PF15832.3 MSTRG.5180.3_3 - 0.021 15.2 8.0 0.038 14.4 8.0 1.5 1 0 0 1 1 1 0 FAM27 D and E protein family Glyco_hydro_26 PF02156.13 MSTRG.9819.1_1 - 0.27 10.5 2.8 0.37 10.0 2.8 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 26 Cadherin PF00028.15 MSTRG.28453.1_2 - 0.056 13.8 0.6 0.14 12.4 0.0 1.8 2 0 0 2 2 2 0 Cadherin domain CTF_NFI PF00859.16 MSTRG.21732.3_1 - 4.2e-07 30.1 0.0 6.7e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 CTF/NF-I family transcription modulation region CTF_NFI PF00859.16 MSTRG.21732.3_2 - 1.8e-67 228.3 16.4 1.8e-65 221.7 16.4 2.3 1 1 0 1 1 1 1 CTF/NF-I family transcription modulation region NfI_DNAbd_pre-N PF10524.7 MSTRG.21732.3_2 - 1.3e-25 88.9 3.8 2.7e-25 87.9 3.8 1.6 1 0 0 1 1 1 1 Nuclear factor I protein pre-N-terminus MH1 PF03165.14 MSTRG.21732.3_2 - 5.3e-09 36.1 0.1 1.1e-08 35.0 0.1 1.6 1 0 0 1 1 1 1 MH1 domain LRRFIP PF09738.7 MSTRG.9164.1_1 - 5.1e-60 203.4 38.2 5.1e-60 203.4 38.2 4.4 2 1 1 3 3 3 2 LRRFIP family Reo_sigmaC PF04582.10 MSTRG.9164.1_1 - 0.36 10.0 3.4 9.5 5.4 1.6 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein T4SS_TraI PF16932.3 MSTRG.9164.1_3 - 0.21 10.7 0.8 0.32 10.1 0.8 1.1 1 0 0 1 1 1 0 Type IV secretory system, conjugal DNA-protein transfer DUF647 PF04884.12 MSTRG.2527.1_1 - 1.4e-95 319.4 0.5 2e-95 318.8 0.5 1.3 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis THAP PF05485.10 MSTRG.2527.1_2 - 7.4e-11 42.7 0.3 2.1e-10 41.3 0.3 1.8 1 0 0 1 1 1 1 THAP domain LigB PF02900.16 MSTRG.2527.1_2 - 0.064 12.2 0.0 0.1 11.5 0.0 1.2 1 0 0 1 1 1 0 Catalytic LigB subunit of aromatic ring-opening dioxygenase DUF3697 PF12478.6 MSTRG.15813.5_1 - 0.098 12.7 2.6 9.2 6.3 0.0 4.8 4 0 0 4 4 4 0 Ubiquitin-associated protein 2 Biotin_lipoyl PF00364.20 MSTRG.24369.2_2 - 6.6e-20 70.6 0.4 1.3e-19 69.7 0.4 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.15 MSTRG.24369.2_2 - 6e-16 58.4 0.1 1.4e-15 57.1 0.1 1.7 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.4 MSTRG.24369.2_2 - 0.0017 18.1 0.2 1.5 8.6 0.1 2.3 1 1 1 2 2 2 2 Biotin-lipoyl like WD40 PF00400.30 MSTRG.4716.1_2 - 1.3e-08 35.2 0.2 0.084 13.6 0.0 3.2 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.4716.1_2 - 0.00014 22.0 0.0 0.00027 21.1 0.0 1.6 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 MSTRG.4716.1_2 - 0.097 11.1 0.1 0.19 10.1 0.1 1.3 1 1 1 2 2 2 0 Nucleoporin Nup120/160 CTF_NFI PF00859.16 MSTRG.8459.1_3 - 2.6e-13 50.5 2.2 3.7e-13 50.0 2.2 1.2 1 0 0 1 1 1 1 CTF/NF-I family transcription modulation region Spc97_Spc98 PF04130.11 MSTRG.12488.1_2 - 3.1e-05 22.8 0.4 3.1e-05 22.8 0.4 1.5 2 0 0 2 2 2 1 Spc97 / Spc98 family Fib_alpha PF08702.8 MSTRG.12488.1_2 - 0.25 11.4 3.4 0.43 10.6 3.4 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Spc97_Spc98 PF04130.11 MSTRG.12488.1_3 - 3e-100 336.4 0.6 3.9e-100 336.0 0.6 1.1 1 0 0 1 1 1 1 Spc97 / Spc98 family Ank_2 PF12796.5 MSTRG.25025.1_1 - 2.9e-41 139.8 6.5 1e-18 67.5 0.2 3.1 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.25025.1_1 - 9e-35 118.5 3.9 4.9e-13 49.2 0.0 4.4 2 2 2 4 4 4 4 Ankyrin repeats (many copies) PRKG1_interact PF15898.3 MSTRG.25025.1_1 - 1e-30 106.5 10.9 1e-30 106.5 10.9 5.5 5 1 1 6 6 6 1 cGMP-dependent protein kinase interacting domain Ank_5 PF13857.4 MSTRG.25025.1_1 - 2.7e-28 97.4 12.2 1.5e-09 37.8 0.3 5.4 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.25025.1_1 - 2.4e-25 87.7 5.7 3.3e-05 24.0 0.0 5.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.4 MSTRG.25025.1_1 - 1.3e-24 83.4 1.5 2.8e-05 24.0 0.0 6.5 7 0 0 7 7 7 4 Ankyrin repeat MIP PF00230.18 MSTRG.22415.3_2 - 2.4e-19 69.9 3.2 3.1e-19 69.5 3.2 1.1 1 0 0 1 1 1 1 Major intrinsic protein Adeno_E1B_55K_N PF04623.10 MSTRG.22415.3_2 - 0.02 15.5 0.1 0.038 14.6 0.1 1.4 1 0 0 1 1 1 0 Adenovirus E1B protein N-terminus IRF-2BP1_2 PF11261.6 MSTRG.19345.1_2 - 8.7e-34 114.7 0.9 1.5e-33 114.0 0.9 1.4 1 0 0 1 1 1 1 Interferon regulatory factor 2-binding protein zinc finger DUF4658 PF15555.4 MSTRG.19345.1_2 - 0.22 11.5 4.0 2.3 8.1 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4658) SPOC PF07744.11 MSTRG.20240.1_3 - 8.2e-38 129.5 0.0 1.6e-37 128.6 0.0 1.5 1 0 0 1 1 1 1 SPOC domain PIH1 PF08190.10 MSTRG.16945.1_2 - 0.0029 17.4 0.0 0.0051 16.6 0.0 1.3 1 0 0 1 1 1 1 pre-RNA processing PIH1/Nop17 Arrestin_N PF00339.27 MSTRG.10633.1_3 - 8.2e-33 113.4 0.1 8.1e-32 110.2 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.20 MSTRG.10633.1_3 - 1.2e-23 83.8 0.0 1.1e-17 64.5 0.0 2.5 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Vps26 PF03643.13 MSTRG.10633.1_3 - 8.6e-05 21.5 0.0 0.00016 20.7 0.0 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Spo0M PF07070.9 MSTRG.10633.1_3 - 0.0087 15.5 0.1 0.69 9.3 0.0 2.3 2 0 0 2 2 2 1 SpoOM protein Rgp1 PF08737.8 MSTRG.10633.1_3 - 0.055 12.5 0.0 0.14 11.1 0.0 1.6 2 0 0 2 2 2 0 Rgp1 G-alpha PF00503.18 MSTRG.8584.1_3 - 1.1e-117 393.0 2.2 1.5e-117 392.6 2.2 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 MSTRG.8584.1_3 - 7.9e-16 57.9 0.5 1.3e-10 40.9 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 MSTRG.8584.1_3 - 0.0053 16.0 4.0 0.12 11.6 0.4 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region AAA_29 PF13555.4 MSTRG.8584.1_3 - 0.053 13.1 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.21 MSTRG.8584.1_3 - 0.08 12.9 0.5 4.6 7.2 0.3 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase TniB PF05621.9 MSTRG.8584.1_3 - 0.085 11.9 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein Roc PF08477.11 MSTRG.8584.1_3 - 0.094 12.8 1.8 5.6 7.1 0.3 2.8 2 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase TMEM171 PF15471.4 MSTRG.16471.1_3 - 0.27 10.0 2.0 0.3 9.9 2.0 1.0 1 0 0 1 1 1 0 Transmembrane protein family 171 MRF_C1 PF13887.4 MSTRG.21040.2_3 - 0.17 10.9 0.4 0.35 9.9 0.4 1.4 1 0 0 1 1 1 0 Myelin gene regulatory factor -C-terminal domain 1 Hydrolase PF00702.24 MSTRG.20909.1_3 - 0.0011 19.1 0.1 0.0015 18.7 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.4 MSTRG.20909.1_3 - 0.0085 16.1 0.0 0.016 15.2 0.0 1.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Aa_trans PF01490.16 MSTRG.2297.2_2 - 5.7e-25 87.7 36.5 3.6e-13 48.9 6.4 2.1 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein Cortexin PF11057.6 MSTRG.2297.2_2 - 0.85 9.4 5.2 0.13 12.0 0.3 2.2 2 0 0 2 2 2 0 Cortexin of kidney Uso1_p115_C PF04871.11 MSTRG.7138.1_3 - 4.2e-05 23.8 15.9 7.1e-05 23.0 15.9 1.3 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, C terminal region GIT_CC PF16559.3 MSTRG.7138.1_3 - 0.005 16.7 7.8 0.24 11.3 0.6 3.2 2 1 1 3 3 3 2 GIT coiled-coil Rho guanine nucleotide exchange factor Birna_VP3 PF01767.14 MSTRG.7138.1_3 - 0.0082 16.1 1.0 0.011 15.7 1.0 1.1 1 0 0 1 1 1 1 Birnavirus VP3 protein IncA PF04156.12 MSTRG.7138.1_3 - 0.026 14.2 12.5 0.038 13.6 12.5 1.2 1 0 0 1 1 1 0 IncA protein AAA_33 PF13671.4 MSTRG.7138.1_3 - 0.12 12.4 3.7 1.6 8.8 4.3 2.1 1 1 1 2 2 2 0 AAA domain Macoilin PF09726.7 MSTRG.7138.1_3 - 0.19 10.1 12.8 0.25 9.7 12.8 1.0 1 0 0 1 1 1 0 Transmembrane protein DUF4635 PF15466.4 MSTRG.7138.1_3 - 0.23 10.8 3.8 0.14 11.5 1.4 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4635) bZIP_1 PF00170.19 MSTRG.7138.1_3 - 0.54 10.3 19.6 0.16 11.9 10.9 2.7 2 1 0 2 2 2 0 bZIP transcription factor V_ATPase_I PF01496.17 MSTRG.7138.1_3 - 0.59 7.8 5.0 0.75 7.5 5.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family IFP_35_N PF07334.11 MSTRG.7138.1_3 - 0.74 9.8 10.6 0.13 12.2 5.5 2.3 1 1 2 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Mnd1 PF03962.13 MSTRG.7138.1_3 - 0.8 9.4 13.4 1.3 8.7 13.4 1.3 1 0 0 1 1 1 0 Mnd1 family Lectin_N PF03954.12 MSTRG.7138.1_3 - 1.4 8.6 5.9 2.6 7.6 4.1 2.1 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain Exonuc_VII_L PF02601.13 MSTRG.7138.1_3 - 1.5 8.2 6.7 2.1 7.7 6.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.4 MSTRG.7138.1_3 - 1.7 7.8 10.7 2.4 7.3 10.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) APG6 PF04111.10 MSTRG.7138.1_3 - 1.7 7.8 16.0 3 7.0 16.0 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 BRE1 PF08647.9 MSTRG.7138.1_3 - 1.8 8.6 21.6 13 5.8 21.6 2.0 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase OmpH PF03938.12 MSTRG.7138.1_3 - 2.9 7.7 26.7 31 4.4 26.7 2.0 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Prefoldin_2 PF01920.18 MSTRG.7138.1_3 - 3 7.7 19.8 0.65 9.9 4.3 2.4 1 1 0 2 2 2 0 Prefoldin subunit DivIC PF04977.13 MSTRG.7138.1_3 - 3.7 7.3 14.7 0.073 12.7 5.5 2.4 2 0 0 2 2 2 0 Septum formation initiator AAA_11 PF13086.4 MSTRG.7138.1_3 - 4.1 6.9 9.0 7.1 6.1 9.0 1.3 1 0 0 1 1 1 0 AAA domain PET PF06297.12 MSTRG.26560.1_3 - 2e-29 101.6 0.0 3.2e-29 100.9 0.0 1.4 1 0 0 1 1 1 1 PET Domain LIM PF00412.20 MSTRG.26560.1_3 - 1.1e-12 47.9 19.0 1.2e-10 41.3 2.5 3.9 3 2 0 3 3 3 2 LIM domain Yippee-Mis18 PF03226.12 MSTRG.26560.1_3 - 3.8 7.6 7.8 16 5.7 4.2 2.7 3 0 0 3 3 3 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Fox-1_C PF12414.6 MSTRG.7989.1_2 - 9.6e-26 89.8 8.6 2.1e-25 88.7 8.6 1.6 1 0 0 1 1 1 1 Calcitonin gene-related peptide regulator C terminal RRM_1 PF00076.20 MSTRG.7989.1_2 - 9.9e-18 63.6 0.1 1.6e-17 62.9 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fox-1_C PF12414.6 MSTRG.7989.1_3 - 2.8e-13 49.9 6.5 4.8e-13 49.1 6.5 1.3 1 0 0 1 1 1 1 Calcitonin gene-related peptide regulator C terminal DUF758 PF05527.9 MSTRG.8433.2_1 - 5.3e-77 257.8 6.7 7.1e-77 257.3 6.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF758) DUF1722 PF08349.9 MSTRG.8433.2_1 - 0.19 11.8 1.0 30 4.8 0.3 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1722) PRKCSH-like PF12999.5 MSTRG.10942.2_2 - 2.4e-42 144.5 1.2 2.4e-42 144.5 1.2 1.9 2 0 0 2 2 2 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.4 MSTRG.10942.2_2 - 1.1e-21 77.0 0.0 2.1e-21 76.1 0.0 1.4 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.11 MSTRG.10942.2_2 - 2.9e-10 40.9 1.0 2.9e-10 40.9 1.0 2.3 3 0 0 3 3 2 1 Glucosidase II beta subunit-like protein EF-hand_6 PF13405.4 MSTRG.10942.2_2 - 9.7e-05 21.9 0.7 0.0032 17.1 0.1 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.4 MSTRG.10942.2_2 - 0.00022 20.4 0.4 0.0017 17.6 0.2 2.3 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.30 MSTRG.10942.2_2 - 0.00043 19.5 2.1 0.0057 16.0 0.2 2.6 1 1 1 2 2 2 1 EF hand EF-hand_7 PF13499.4 MSTRG.10942.2_2 - 0.0062 16.8 0.8 0.0062 16.8 0.8 2.6 2 1 1 3 3 2 2 EF-hand domain pair Ldl_recept_a PF00057.16 MSTRG.10942.2_2 - 0.0078 16.3 13.4 0.013 15.6 1.4 2.8 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A LXG PF04740.10 MSTRG.10942.2_2 - 0.47 10.0 7.0 0.2 11.2 0.2 2.7 2 1 1 3 3 3 0 LXG domain of WXG superfamily RF-1 PF00472.18 MSTRG.10942.2_2 - 2.5 7.9 7.6 4.3 7.2 0.0 2.6 2 0 0 2 2 2 0 RF-1 domain Atg14 PF10186.7 MSTRG.10942.2_2 - 8.2 5.3 8.4 21 3.9 5.4 2.1 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Carb_kinase PF01256.15 MSTRG.16226.1_2 - 1.2e-57 195.1 0.1 1.4e-57 194.8 0.1 1.1 1 0 0 1 1 1 1 Carbohydrate kinase HK PF02110.13 MSTRG.16226.1_2 - 0.0043 16.3 0.0 0.0063 15.8 0.0 1.3 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family Phos_pyr_kin PF08543.10 MSTRG.16226.1_2 - 0.011 15.0 0.1 0.039 13.2 0.0 1.9 2 0 0 2 2 2 0 Phosphomethylpyrimidine kinase FIIND PF13553.4 MSTRG.7480.1_2 - 3.6e-51 173.8 0.0 4.4e-51 173.5 0.0 1.1 1 0 0 1 1 1 1 Function to find CARD PF00619.19 MSTRG.7480.1_2 - 8.5e-13 48.0 0.4 1.8e-12 47.0 0.4 1.5 1 0 0 1 1 1 1 Caspase recruitment domain Filamin PF00630.17 MSTRG.24272.1_1 - 0 1263.6 36.7 2.8e-21 76.1 0.0 24.3 24 0 0 24 24 24 24 Filamin/ABP280 repeat CH PF00307.29 MSTRG.24272.1_1 - 1.1e-38 131.7 0.5 2.1e-19 69.6 0.9 2.3 2 0 0 2 2 2 2 Calponin homology (CH) domain Y_Y_Y PF07495.11 MSTRG.24272.1_1 - 2.5e-20 72.1 18.3 0.16 11.8 0.0 14.8 17 0 0 17 17 15 3 Y_Y_Y domain DUF5060 PF16586.3 MSTRG.24272.1_1 - 1.7e-13 50.6 0.1 5.9 7.2 0.0 13.5 16 0 0 16 16 14 1 Domain of unknown function (DUF5060) Big_3_5 PF16640.3 MSTRG.24272.1_1 - 1e-12 47.9 29.6 0.097 12.7 0.1 12.7 14 0 0 14 14 14 4 Bacterial Ig-like domain (group 3) YtkA PF13115.4 MSTRG.24272.1_1 - 6.2e-07 29.8 6.7 3.3 8.2 0.0 10.9 14 0 0 14 14 12 1 YtkA-like Invasin_D3 PF09134.8 MSTRG.24272.1_1 - 0.00057 19.4 2.1 37 4.0 0.0 6.4 5 0 0 5 5 5 0 Invasin, domain 3 CAMSAP_CH PF11971.6 MSTRG.24272.1_1 - 0.0017 18.0 0.1 2.3 8.0 0.0 2.6 2 0 0 2 2 2 2 CAMSAP CH domain DUF4369 PF14289.4 MSTRG.24272.1_1 - 0.0063 17.0 0.1 1.3 9.6 0.1 4.4 3 1 0 3 3 3 1 Domain of unknown function (DUF4369) PapC_N PF13954.4 MSTRG.24272.1_1 - 0.034 14.0 0.0 7.7 6.3 0.0 4.3 4 0 0 4 4 3 0 PapC N-terminal domain EMP24_GP25L PF01105.22 MSTRG.24272.1_1 - 0.051 13.4 0.1 19 5.0 0.0 4.8 5 0 0 5 5 5 0 emp24/gp25L/p24 family/GOLD CH_2 PF06294.9 MSTRG.24272.1_1 - 0.079 13.0 0.1 17 5.5 0.0 2.3 2 0 0 2 2 2 0 CH-like domain in sperm protein DUF3568 PF12092.6 MSTRG.24272.1_1 - 0.11 12.5 0.4 13 5.8 0.0 4.5 6 0 0 6 6 5 0 Protein of unknown function (DUF3568) gpW PF02831.13 MSTRG.24272.1_1 - 0.12 12.0 0.1 38 4.0 0.0 3.4 2 0 0 2 2 2 0 gpW DUF971 PF06155.10 MSTRG.24272.1_1 - 0.12 12.9 0.0 49 4.5 0.0 4.6 5 0 0 5 5 4 0 Protein of unknown function (DUF971) LBP_BPI_CETP PF01273.23 MSTRG.24272.1_1 - 0.19 11.2 0.0 1.3 8.4 0.0 2.3 2 0 0 2 2 2 0 LBP / BPI / CETP family, N-terminal domain Inhibitor_I42 PF09394.8 MSTRG.24272.1_1 - 0.21 11.8 1.1 19 5.5 0.0 5.0 6 1 1 7 7 5 0 Chagasin family peptidase inhibitor I42 PPC PF04151.13 MSTRG.24272.1_1 - 1.4 9.9 12.9 1.2e+02 3.8 0.0 7.9 9 0 0 9 9 5 0 Bacterial pre-peptidase C-terminal domain Big_3 PF07523.10 MSTRG.24272.1_1 - 3.8 7.7 21.2 28 5.0 0.0 9.8 10 3 2 12 12 10 0 Bacterial Ig-like domain (group 3) DUF1168 PF06658.10 MSTRG.28999.1_3 - 0.061 13.0 0.0 0.081 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) Phospholip_B PF04916.11 MSTRG.7947.4_2 - 5.6e-28 97.7 0.2 6.7e-28 97.4 0.2 1.0 1 0 0 1 1 1 1 Phospholipase B DUF4461 PF14688.4 MSTRG.13424.1_1 - 4.3e-95 318.9 2.3 5.7e-95 318.5 2.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4461) Drf_FH3 PF06367.14 MSTRG.15739.1_1 - 3e-30 105.2 2.0 4.6e-30 104.6 2.0 1.2 1 0 0 1 1 1 1 Diaphanous FH3 Domain Drf_GBD PF06371.11 MSTRG.15739.1_1 - 1.7e-23 83.0 0.0 2.6e-23 82.4 0.0 1.3 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain RRM_1 PF00076.20 MSTRG.3369.3_3 - 8e-24 83.1 0.1 1.3e-23 82.4 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM1CTR PF08081.9 MSTRG.3369.3_3 - 5.3e-18 64.7 24.3 5.3e-18 64.7 24.3 6.6 4 2 4 8 8 8 1 RBM1CTR (NUC064) family RRM_7 PF16367.3 MSTRG.3369.3_3 - 0.004 17.1 0.0 0.0097 15.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif Nup35_RRM_2 PF14605.4 MSTRG.3369.3_3 - 0.017 14.9 0.0 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.4 MSTRG.3369.3_3 - 0.068 12.6 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_8 PF12780.5 MSTRG.19124.1_1 - 6.9e-24 84.3 0.2 1.2e-23 83.5 0.2 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 MT PF12777.5 MSTRG.19124.1_1 - 7.7e-23 80.9 7.0 9.5e-23 80.6 7.0 1.1 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor SCAB_CC PF16712.3 MSTRG.19124.1_1 - 0.0046 16.5 5.0 0.0069 16.0 5.0 1.2 1 0 0 1 1 1 1 Coiled-coil regions of plant-specific actin-binding protein UvrD-helicase PF00580.19 MSTRG.19124.1_1 - 0.0067 15.9 0.4 0.0082 15.6 0.4 1.2 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain Ly49 PF08391.8 MSTRG.19124.1_1 - 0.051 13.8 0.6 0.12 12.6 0.3 1.7 1 1 0 2 2 2 0 Ly49-like protein, N-terminal region WWamide PF08258.9 MSTRG.19124.1_2 - 4.4 7.9 6.7 17 6.1 1.0 3.6 2 0 0 2 2 2 0 WWamide peptide UPF0544 PF15749.3 MSTRG.25801.2_1 - 7.2e-12 45.9 11.4 7.2e-12 45.9 11.4 1.4 2 0 0 2 2 2 1 Uncharacterised protein family UPF0544 GST_N PF02798.18 MSTRG.3193.1_1 - 6.7e-19 67.9 0.0 1.3e-18 67.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.4 MSTRG.3193.1_1 - 3.5e-17 62.3 0.1 5.9e-17 61.6 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 MSTRG.3193.1_1 - 7.4e-12 45.2 0.0 1.3e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.2 MSTRG.3193.1_1 - 5e-05 22.9 0.4 0.00011 21.7 0.4 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 MSTRG.3193.1_1 - 0.00015 21.5 0.2 0.00054 19.7 0.2 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 MSTRG.3193.1_1 - 0.035 14.4 0.0 0.071 13.4 0.0 1.6 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 MSTRG.3193.1_1 - 0.088 13.0 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain MRVI1 PF05781.10 MSTRG.23500.2_3 - 5e-100 335.6 11.5 7.3e-100 335.0 11.5 1.3 1 0 0 1 1 1 1 MRVI1 protein DUF919 PF06034.9 MSTRG.23500.2_3 - 0.11 12.2 2.3 0.18 11.5 0.4 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) DUF3040 PF11239.6 MSTRG.23500.2_3 - 0.12 12.5 1.2 0.42 10.8 1.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) MHC_I PF00129.16 MSTRG.19692.9_1 - 3.1e-13 49.5 0.0 4.8e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 MHC_I PF00129.16 MSTRG.19692.9_2 - 6.3e-09 35.5 0.3 8.8e-09 35.0 0.3 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 NAD_binding_2 PF03446.13 MSTRG.2160.4_2 - 3.1e-36 124.8 0.0 5.2e-36 124.1 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.4 MSTRG.2160.4_2 - 8.7e-20 71.1 1.5 1.4e-19 70.4 1.5 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase PWWP PF00855.15 MSTRG.2160.4_2 - 3e-14 53.1 0.3 5.5e-14 52.3 0.3 1.4 1 0 0 1 1 1 1 PWWP domain F420_oxidored PF03807.15 MSTRG.2160.4_2 - 7e-06 26.4 0.0 1.4e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.18 MSTRG.2160.4_2 - 0.0039 17.1 0.0 0.007 16.3 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.14 MSTRG.2160.4_2 - 0.0054 16.3 0.0 0.0084 15.6 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.17 MSTRG.2160.4_2 - 0.0056 15.9 0.0 0.0093 15.2 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.16 MSTRG.2160.4_2 - 0.053 13.3 0.0 0.098 12.4 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.16 MSTRG.2160.4_2 - 0.058 13.5 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DUF1048 PF06304.9 MSTRG.2160.4_2 - 0.17 12.2 0.0 0.32 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1048) TRAP_alpha PF03896.14 MSTRG.19238.1_3 - 1.9e-113 378.3 0.1 2.6e-113 377.8 0.1 1.2 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit Nop14 PF04147.10 MSTRG.19238.1_3 - 0.5 8.4 9.7 0.66 8.0 9.7 1.1 1 0 0 1 1 1 0 Nop14-like family Sec23_trunk PF04811.13 MSTRG.20880.2_2 - 5.5e-82 274.8 0.0 9.8e-82 274.0 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.13 MSTRG.20880.2_2 - 4.8e-29 100.1 1.4 1.1e-28 98.9 1.4 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.10 MSTRG.20880.2_2 - 2.6e-21 76.0 0.0 5.4e-21 75.0 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.13 MSTRG.20880.2_2 - 2.6e-14 52.8 5.4 5.9e-14 51.7 5.4 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.20 MSTRG.20880.2_2 - 8.8e-06 25.4 0.0 2.4e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 Gelsolin repeat HpaB PF03241.11 MSTRG.20880.2_2 - 0.0023 16.9 0.0 0.11 11.4 0.0 2.2 2 0 0 2 2 2 1 4-hydroxyphenylacetate 3-hydroxylase C terminal Cwf_Cwc_15 PF04889.10 MSTRG.20880.2_2 - 1.4 8.4 4.2 2.2 7.8 4.2 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein FAM176 PF14851.4 MSTRG.20880.2_2 - 1.4 8.4 3.1 2.5 7.6 3.1 1.3 1 0 0 1 1 1 0 FAM176 family Ribosomal_60s PF00428.17 MSTRG.20880.2_2 - 1.5 9.3 6.4 3.8 8.0 6.4 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein NOA36 PF06524.10 MSTRG.20880.2_2 - 1.9 7.7 5.2 3.3 6.9 5.2 1.3 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.8 MSTRG.20880.2_2 - 6.9 7.0 9.3 23 5.3 9.3 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Adap_comp_sub PF00928.19 MSTRG.16597.1_2 - 4.5e-74 249.0 0.0 6.1e-74 248.6 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.18 MSTRG.16597.1_2 - 8.8e-07 28.8 0.8 2.3e-06 27.5 0.0 2.0 2 0 0 2 2 2 1 Clathrin adaptor complex small chain ABC_membrane PF00664.21 MSTRG.16370.3_1 - 1.9e-17 63.7 1.8 2.4e-17 63.4 1.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region DUF4725 PF15854.3 MSTRG.16370.3_1 - 0.14 12.2 0.9 2.5 8.3 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4725) Troponin PF00992.18 MSTRG.14529.1_3 - 1.6e-29 102.8 46.5 7.7e-27 94.1 36.3 2.1 1 1 1 2 2 2 2 Troponin Hid1 PF12722.5 MSTRG.14529.1_3 - 2 6.2 14.5 2.5 5.9 14.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PIP49_C PF12260.6 MSTRG.28824.1_3 - 4.5e-13 49.1 0.0 5.1e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 Sushi PF00084.18 MSTRG.25934.1_1 - 6e-23 81.1 18.5 3.7e-11 43.3 1.0 3.7 4 0 0 4 4 4 3 Sushi repeat (SCR repeat) HRM PF02793.20 MSTRG.25934.1_1 - 4.7e-05 23.5 8.5 0.065 13.4 0.4 3.2 3 0 0 3 3 3 3 Hormone receptor domain VWA PF00092.26 MSTRG.11251.1_3 - 1.6e-48 165.1 0.0 2e-48 164.9 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.4 MSTRG.11251.1_3 - 8.9e-16 58.4 0.0 2.4e-15 57.0 0.0 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain AMP-binding PF00501.26 MSTRG.7224.1_2 - 6.9e-48 163.1 0.0 9.5e-48 162.7 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 MSTRG.7224.1_2 - 0.00091 20.0 0.0 0.0017 19.2 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain MFS_1 PF07690.14 MSTRG.9999.1_3 - 7e-42 143.5 63.4 8.9e-32 110.2 33.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 MSTRG.9999.1_3 - 0.0029 16.4 2.7 0.0029 16.4 2.7 2.8 2 1 1 3 3 3 2 Sugar (and other) transporter UreE_N PF02814.13 MSTRG.4814.2_2 - 0.016 14.6 14.0 0.89 9.1 0.0 5.3 2 1 4 7 7 7 0 UreE urease accessory protein, N-terminal domain UDPGP PF01704.16 MSTRG.29798.1_1 - 3.5e-133 444.1 0.0 4.3e-133 443.8 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase zf-H2C2_2 PF13465.4 MSTRG.8369.1_1 - 7.7e-22 76.6 10.7 3.2e-08 33.5 0.4 3.1 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.8369.1_1 - 3.4e-09 36.6 20.4 0.0002 21.8 2.0 3.9 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2 PF00096.24 MSTRG.8369.1_1 - 1e-08 35.0 21.4 0.00035 20.7 0.9 3.8 4 0 0 4 4 4 3 Zinc finger, C2H2 type DUF2180 PF09947.7 MSTRG.8369.1_1 - 0.0099 15.7 6.5 0.62 9.9 1.6 2.5 1 1 2 3 3 3 2 Uncharacterized protein conserved in archaea (DUF2180) CNRIP1 PF15043.4 MSTRG.8369.1_1 - 0.01 15.3 0.0 1.9 7.9 0.0 2.2 1 1 1 2 2 2 0 CB1 cannabinoid receptor-interacting protein 1 zf-CHCC PF10276.7 MSTRG.8369.1_1 - 0.011 15.6 5.7 2 8.4 0.4 3.0 3 0 0 3 3 3 0 Zinc-finger domain Siva PF05458.10 MSTRG.8369.1_1 - 0.018 14.6 3.1 0.021 14.4 3.1 1.1 1 0 0 1 1 1 0 Cd27 binding protein (Siva) zf-UBP PF02148.17 MSTRG.8369.1_1 - 0.033 14.4 5.7 0.082 13.1 5.7 1.9 1 1 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein zf-Di19 PF05605.10 MSTRG.8369.1_1 - 0.08 13.1 12.0 0.71 10.1 6.7 2.6 1 1 2 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding LIM PF00412.20 MSTRG.8369.1_1 - 0.29 11.2 8.2 5.1 7.3 7.3 2.5 1 1 0 1 1 1 0 LIM domain IBD PF10416.7 MSTRG.8369.1_1 - 0.33 10.9 1.5 4.3 7.2 0.1 2.6 1 1 2 3 3 3 0 Transcription-initiator DNA-binding domain IBD zf-C2HE PF16278.3 MSTRG.8369.1_1 - 0.4 11.1 9.0 1.3 9.4 0.2 2.7 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger Cas_TM1802 PF09484.8 MSTRG.8369.1_1 - 0.47 9.0 4.4 0.25 9.9 0.4 1.8 1 1 1 2 2 2 0 CRISPR-associated protein TM1802 (cas_TM1802) Elf1 PF05129.11 MSTRG.8369.1_1 - 0.63 10.0 8.2 4.5 7.3 0.3 2.6 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf-AN1 PF01428.14 MSTRG.8369.1_1 - 1.1 9.3 15.4 0.096 12.7 2.9 3.0 2 1 1 3 3 3 0 AN1-like Zinc finger zf-trcl PF13451.4 MSTRG.8369.1_1 - 1.2 8.9 10.4 6 6.7 0.7 3.2 3 0 0 3 3 3 0 Probable zinc-ribbon domain FYVE PF01363.19 MSTRG.8369.1_1 - 2.3 8.3 11.4 5.8 7.0 11.4 1.8 1 1 0 1 1 1 0 FYVE zinc finger zf-met PF12874.5 MSTRG.8369.1_1 - 3.3 8.1 15.6 2.4 8.5 0.2 3.9 4 0 0 4 4 4 0 Zinc-finger of C2H2 type DUF2225 PF09986.7 MSTRG.8369.1_1 - 4.3 6.9 6.6 31 4.1 5.9 2.1 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) Zn-ribbon_8 PF09723.8 MSTRG.8369.1_1 - 4.8 7.3 10.5 12 6.0 3.0 2.5 1 1 2 3 3 3 0 Zinc ribbon domain Chordopox_RPO7 PF05864.10 MSTRG.8369.1_1 - 8.3 6.6 7.7 24 5.1 0.3 3.0 3 0 0 3 3 3 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) RRM_1 PF00076.20 MSTRG.19847.6_1 - 9.6e-12 44.4 1.3 2.1e-08 33.7 0.1 2.8 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 MSTRG.19847.6_1 - 4.4e-07 29.4 2.4 1.1e-05 24.9 0.2 2.8 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 MSTRG.19847.6_3 - 2.7e-33 114.1 0.1 8.3e-27 93.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.20 MSTRG.19847.6_3 - 7.9e-10 38.3 0.1 0.00057 19.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 MSTRG.19847.6_3 - 0.00031 20.4 0.1 0.29 10.9 0.0 2.3 2 0 0 2 2 2 2 Occluded RNA-recognition motif Myb_DNA-binding PF00249.29 MSTRG.27106.2_3 - 2.9e-10 40.0 0.0 8.2e-10 38.6 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM PF04433.15 MSTRG.27106.2_3 - 2.5e-07 30.8 0.0 9.7e-07 28.9 0.0 2.0 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-bind_6 PF13921.4 MSTRG.27106.2_3 - 2.7e-05 24.2 1.0 9.6e-05 22.4 0.1 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain RPA_C PF08784.9 MSTRG.27106.2_3 - 0.16 12.5 0.0 0.32 11.6 0.0 1.4 1 0 0 1 1 1 0 Replication protein A C terminal FAM76 PF16046.3 MSTRG.11611.3_3 - 0.02 14.2 5.0 0.032 13.4 5.0 1.3 1 0 0 1 1 1 0 FAM76 protein MerR-DNA-bind PF09278.9 MSTRG.11611.3_3 - 1.3 9.5 3.8 38 4.8 0.0 3.5 4 0 0 4 4 4 0 MerR, DNA binding LIM PF00412.20 MSTRG.19000.1_3 - 2.1e-13 50.2 6.3 3.5e-13 49.4 6.3 1.4 1 0 0 1 1 1 1 LIM domain DUF329 PF03884.12 MSTRG.19000.1_3 - 1.6 8.4 6.0 1.6 8.3 3.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF329) p47_phox_C PF08944.9 MSTRG.15654.3_3 - 0.03 13.6 2.2 0.089 12.1 2.2 1.8 1 0 0 1 1 1 0 NADPH oxidase subunit p47Phox, C terminal domain 2-Hacid_dh_C PF02826.17 MSTRG.10331.2_3 - 1.5e-55 187.2 0.0 2e-55 186.7 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.28 MSTRG.10331.2_3 - 2.4e-27 95.1 0.0 3.3e-27 94.7 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.13 MSTRG.10331.2_3 - 0.00015 21.8 0.0 0.00026 21.1 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Toxin_2 PF00451.17 MSTRG.11432.1_1 - 0.25 11.5 6.8 0.64 10.2 6.8 1.7 1 0 0 1 1 1 0 Scorpion short toxin, BmKK2 IL8 PF00048.18 MSTRG.11432.1_2 - 3e-09 36.7 2.6 7e-09 35.6 2.6 1.6 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like CLU PF13236.4 MSTRG.5655.1_2 - 2.8e-53 180.9 0.0 4.9e-53 180.1 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.5 MSTRG.5655.1_2 - 2.6e-45 154.5 0.8 6.4e-45 153.2 0.0 2.1 3 0 0 3 3 3 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.4 MSTRG.5655.1_2 - 3.9e-11 42.9 11.9 1.6e-05 24.9 0.0 3.9 2 1 1 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.5655.1_2 - 1.2e-08 34.4 2.9 0.0023 17.6 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat CLU_N PF15044.4 MSTRG.5655.1_2 - 1.4e-05 25.3 0.0 3.1e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term APO_RNA-bind PF05634.9 MSTRG.5655.1_2 - 0.003 16.9 0.0 0.032 13.5 0.0 2.2 2 0 0 2 2 2 1 APO RNA-binding EcoR124_C PF12008.6 MSTRG.5655.1_2 - 0.011 15.3 0.0 0.065 12.7 0.0 2.0 2 0 0 2 2 2 0 Type I restriction and modification enzyme - subunit R C terminal DUF727 PF05303.10 MSTRG.5655.1_2 - 0.039 13.9 0.0 0.09 12.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF727) Mor PF08765.9 MSTRG.5655.1_2 - 0.086 12.7 0.1 0.21 11.4 0.1 1.6 1 0 0 1 1 1 0 Mor transcription activator family TPR_16 PF13432.4 MSTRG.5655.1_2 - 3.5 8.3 5.6 31 5.2 1.9 3.1 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.5655.1_2 - 3.8 7.7 7.4 26 5.1 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Crystall PF00030.17 MSTRG.15392.9_2 - 1.8e-92 303.5 7.9 4.4e-24 84.4 0.8 5.4 5 0 0 5 5 5 5 Beta/Gamma crystallin Ricin_B_lectin PF00652.20 MSTRG.15392.9_2 - 8e-09 35.7 0.0 1.3e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Inhibitor_I36 PF03995.11 MSTRG.15392.9_2 - 0.0003 20.5 1.2 4.6 7.1 0.0 4.5 5 1 0 5 5 5 2 Peptidase inhibitor family I36 RicinB_lectin_2 PF14200.4 MSTRG.15392.9_2 - 0.0071 16.9 0.0 0.22 12.2 0.0 2.8 1 1 1 2 2 2 1 Ricin-type beta-trefoil lectin domain-like FOXP-CC PF16159.3 MSTRG.13864.1_1 - 1.5e-33 115.0 5.3 1.5e-33 115.0 5.3 3.5 3 1 1 4 4 4 1 FOXP coiled-coil domain Forkhead PF00250.16 MSTRG.13864.1_1 - 3.5e-28 97.6 0.2 9.9e-28 96.2 0.2 1.8 1 0 0 1 1 1 1 Forkhead domain Peptidase_S49_N PF08496.8 MSTRG.13864.1_1 - 1.4 8.9 23.2 0.088 12.8 14.5 2.6 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Ion_trans PF00520.29 MSTRG.3788.1_2 - 1.3e-60 204.6 17.7 1.4e-60 204.4 17.7 1.0 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.10 MSTRG.3788.1_2 - 0.0017 17.0 19.0 0.049 12.2 2.7 3.1 3 0 0 3 3 3 3 Polycystin cation channel CBM_21 PF03370.11 MSTRG.4378.1_3 - 1.4e-28 99.2 0.1 2e-28 98.7 0.1 1.2 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.3 MSTRG.4378.1_3 - 3.2e-10 40.3 0.7 3.2e-10 40.3 0.7 1.6 2 0 0 2 2 2 1 Starch/carbohydrate-binding module (family 53) DBB PF14545.4 MSTRG.8994.2_2 - 0.11 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Dof, BCAP, and BANK (DBB) motif, PRELI PF04707.12 MSTRG.7418.1_3 - 3.2e-48 163.4 0.1 4.6e-48 162.9 0.1 1.2 1 0 0 1 1 1 1 PRELI-like family DUF3551 PF12071.6 MSTRG.20881.1_2 - 0.054 13.4 0.0 0.079 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3551) PAS_9 PF13426.5 MSTRG.6790.1_1 - 4.2e-18 65.3 0.0 6.3e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.10 MSTRG.6790.1_1 - 1.5e-08 34.6 0.0 2.4e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.8 MSTRG.6790.1_1 - 0.0001 22.4 0.0 0.0002 21.4 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS PF00989.23 MSTRG.6790.1_1 - 0.0016 18.3 0.0 0.0032 17.3 0.0 1.5 1 1 0 1 1 1 1 PAS fold MIF4G_like_2 PF09090.9 MSTRG.15883.2_3 - 3.1e-86 289.0 7.4 4.8e-86 288.3 7.4 1.3 1 0 0 1 1 1 1 MIF4G like MIF4G_like PF09088.9 MSTRG.15883.2_3 - 4.6e-38 130.7 0.3 2e-37 128.6 0.2 2.0 2 0 0 2 2 2 1 MIF4G like Vfa1 PF08432.8 MSTRG.15883.2_3 - 0.015 15.5 5.2 0.027 14.7 5.2 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 PHM7_cyt PF14703.4 MSTRG.15883.2_3 - 0.015 15.4 3.4 0.029 14.5 3.4 1.4 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter Jnk-SapK_ap_N PF09744.7 MSTRG.15883.2_3 - 0.017 15.2 7.3 0.034 14.2 7.3 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Mnd1 PF03962.13 MSTRG.15883.2_3 - 0.017 14.9 5.9 0.031 14.0 5.9 1.4 1 0 0 1 1 1 0 Mnd1 family DUF342 PF03961.11 MSTRG.15883.2_3 - 0.022 13.2 2.1 0.031 12.8 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF1664 PF07889.10 MSTRG.15883.2_3 - 0.059 13.2 3.0 0.13 12.1 3.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF106 PF01956.14 MSTRG.15883.2_3 - 0.062 12.9 2.1 0.11 12.1 2.1 1.3 1 0 0 1 1 1 0 Integral membrane protein DUF106 HemX PF04375.12 MSTRG.15883.2_3 - 0.072 12.2 4.4 0.13 11.4 4.4 1.4 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase tRNA_bind_2 PF13725.4 MSTRG.15883.2_3 - 0.079 12.6 6.8 0.15 11.6 6.8 1.4 1 0 0 1 1 1 0 Possible tRNA binding domain OmpH PF03938.12 MSTRG.15883.2_3 - 0.091 12.6 9.9 0.17 11.8 9.9 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF1510 PF07423.9 MSTRG.15883.2_3 - 0.094 12.0 6.3 0.15 11.4 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) GBP_C PF02841.12 MSTRG.15883.2_3 - 0.11 11.8 8.3 0.18 11.0 8.3 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain DUF4407 PF14362.4 MSTRG.15883.2_3 - 0.11 11.7 0.5 0.18 11.0 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) IncA PF04156.12 MSTRG.15883.2_3 - 0.12 12.1 4.5 0.2 11.3 4.5 1.3 1 0 0 1 1 1 0 IncA protein AAA_11 PF13086.4 MSTRG.15883.2_3 - 0.14 11.7 3.4 0.24 11.0 3.4 1.3 1 0 0 1 1 1 0 AAA domain Folliculin PF11704.6 MSTRG.15883.2_3 - 0.15 11.8 4.8 0.24 11.1 4.8 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Swi5 PF07061.9 MSTRG.15883.2_3 - 0.15 12.0 8.1 1.1 9.2 1.8 2.5 2 0 0 2 2 2 0 Swi5 DUF2203 PF09969.7 MSTRG.15883.2_3 - 0.16 12.6 3.4 0.32 11.6 3.4 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Cob_adeno_trans PF01923.16 MSTRG.15883.2_3 - 0.26 11.3 1.6 0.61 10.1 1.6 1.6 1 0 0 1 1 1 0 Cobalamin adenosyltransferase CLZ PF16526.3 MSTRG.15883.2_3 - 0.33 11.2 8.9 3.9 7.7 1.5 3.2 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels PRKG1_interact PF15898.3 MSTRG.15883.2_3 - 0.42 11.4 8.6 0.86 10.4 8.6 1.5 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Alanine_zipper PF11839.6 MSTRG.15883.2_3 - 0.45 10.7 3.2 3.3 7.9 0.6 2.3 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein SOGA PF11365.6 MSTRG.15883.2_3 - 0.68 11.0 10.4 1.4 10.0 10.4 1.5 1 0 0 1 1 1 0 Protein SOGA Atg14 PF10186.7 MSTRG.15883.2_3 - 0.89 8.4 6.6 2.8 6.8 5.4 2.0 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 CorA PF01544.16 MSTRG.15883.2_3 - 1.2 8.2 5.8 1.2 8.2 0.3 2.3 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Prefoldin_2 PF01920.18 MSTRG.15883.2_3 - 1.3 8.9 14.4 4.5 7.2 2.2 2.4 2 0 0 2 2 2 0 Prefoldin subunit DASH_Spc34 PF08657.8 MSTRG.15883.2_3 - 2.5 7.8 10.5 4.5 6.9 10.5 1.4 1 0 0 1 1 1 0 DASH complex subunit Spc34 Fib_alpha PF08702.8 MSTRG.15883.2_3 - 3.1 7.8 9.8 1.9 8.6 6.7 2.1 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family RmuC PF02646.14 MSTRG.15883.2_3 - 3.8 6.4 10.8 1.6 7.7 0.8 2.3 1 1 1 2 2 2 0 RmuC family DivIC PF04977.13 MSTRG.15883.2_3 - 5 6.8 8.5 7.1 6.3 1.6 2.6 2 0 0 2 2 2 0 Septum formation initiator SlyX PF04102.10 MSTRG.15883.2_3 - 7.1 7.2 9.6 13 6.4 2.4 3.0 1 1 1 2 2 2 0 SlyX DUF4116 PF13475.4 MSTRG.16063.2_2 - 0.11 12.2 0.1 0.45 10.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4116) Lectin_C PF00059.19 MSTRG.12578.1_3 - 9.3e-17 61.6 12.5 1.8e-16 60.7 9.7 2.2 2 0 0 2 2 2 1 Lectin C-type domain IncA PF04156.12 MSTRG.12578.1_3 - 0.012 15.2 0.3 0.023 14.4 0.3 1.3 1 0 0 1 1 1 0 IncA protein Ly49 PF08391.8 MSTRG.12578.1_3 - 0.038 14.2 0.1 0.038 14.2 0.1 1.9 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region SlyX PF04102.10 MSTRG.12578.1_3 - 0.2 12.2 2.5 0.37 11.3 2.5 1.4 1 0 0 1 1 1 0 SlyX zf-H2C2_2 PF13465.4 MSTRG.4999.1_2 - 2.2e-58 192.1 48.8 2.9e-09 36.8 0.6 8.9 8 0 0 8 8 8 7 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.4999.1_2 - 3.5e-35 118.4 59.4 2.2e-05 24.5 1.2 9.1 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.4999.1_2 - 7e-23 79.2 63.0 0.0019 18.7 1.1 9.2 9 0 0 9 9 8 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.4999.1_2 - 5.8e-10 39.1 12.4 1.1 9.6 0.0 8.2 8 0 0 8 8 7 1 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 MSTRG.4999.1_2 - 8.4e-08 32.1 25.0 0.011 15.7 2.1 6.2 2 1 4 6 6 6 5 Zinc ribbon domain zinc_ribbon_15 PF17032.3 MSTRG.4999.1_2 - 2.9e-07 31.0 18.4 0.4 11.3 0.1 4.6 1 1 2 4 4 4 4 zinc-ribbon family zf-Di19 PF05605.10 MSTRG.4999.1_2 - 1.5e-06 28.3 39.8 0.0017 18.5 1.7 6.1 3 2 2 6 6 5 5 Drought induced 19 protein (Di19), zinc-binding HypA PF01155.17 MSTRG.4999.1_2 - 6.4e-05 22.8 19.3 0.2 11.6 0.1 4.6 1 1 2 3 3 3 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-met PF12874.5 MSTRG.4999.1_2 - 8.2e-05 22.7 42.0 0.079 13.2 0.3 8.7 8 0 0 8 8 8 2 Zinc-finger of C2H2 type LIM PF00412.20 MSTRG.4999.1_2 - 9.2e-05 22.5 25.1 0.052 13.6 1.4 6.0 3 1 2 5 5 5 3 LIM domain zinc_ribbon_4 PF13717.4 MSTRG.4999.1_2 - 0.0003 20.5 22.4 0.7 9.7 3.0 7.0 6 1 0 6 6 6 2 zinc-ribbon domain Elf1 PF05129.11 MSTRG.4999.1_2 - 0.0006 19.7 29.2 0.043 13.7 1.5 5.5 2 1 6 8 8 8 5 Transcription elongation factor Elf1 like zf-C2H2_6 PF13912.4 MSTRG.4999.1_2 - 0.0013 18.4 52.3 1.6 8.6 0.1 9.4 8 3 0 8 8 8 4 C2H2-type zinc finger zf-AN1 PF01428.14 MSTRG.4999.1_2 - 0.0015 18.5 32.2 12 6.0 0.6 8.5 7 1 1 8 8 8 0 AN1-like Zinc finger zf-FCS PF06467.12 MSTRG.4999.1_2 - 0.0022 17.8 29.2 1.2 9.0 0.6 7.2 1 1 6 7 7 7 3 MYM-type Zinc finger with FCS sequence motif DUF2256 PF10013.7 MSTRG.4999.1_2 - 0.046 13.7 22.6 10 6.2 0.1 7.9 8 0 0 8 8 7 0 Uncharacterized protein conserved in bacteria (DUF2256) DUF3268 PF11672.6 MSTRG.4999.1_2 - 0.05 13.8 16.0 5.9 7.1 0.4 4.3 3 1 0 4 4 4 0 zinc-finger-containing domain Chordopox_RPO7 PF05864.10 MSTRG.4999.1_2 - 0.089 12.9 13.9 33 4.7 0.1 6.6 7 0 0 7 7 7 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) zf-LYAR PF08790.9 MSTRG.4999.1_2 - 0.1 12.4 25.0 9.7 6.1 0.2 7.3 7 0 0 7 7 7 0 LYAR-type C2HC zinc finger ADK_lid PF05191.12 MSTRG.4999.1_2 - 0.19 11.6 22.4 0.62 10.0 0.1 6.1 4 3 3 7 7 6 0 Adenylate kinase, active site lid CpXC PF14353.4 MSTRG.4999.1_2 - 0.2 11.6 25.0 12 5.8 1.5 7.5 5 2 0 6 6 6 0 CpXC protein zf-C2H2_2 PF12756.5 MSTRG.4999.1_2 - 0.21 11.8 32.9 5.4 7.3 0.1 6.8 1 1 3 5 5 5 0 C2H2 type zinc-finger (2 copies) TerY_C PF15616.4 MSTRG.4999.1_2 - 1.6 8.7 16.9 0.26 11.3 1.3 3.7 1 1 5 6 6 6 0 TerY-C metal binding domain zf-DNA_Pol PF08996.8 MSTRG.4999.1_2 - 1.9 8.1 21.9 0.54 9.9 1.8 3.8 1 1 2 3 3 3 0 DNA Polymerase alpha zinc finger zf-RING_7 PF02591.13 MSTRG.4999.1_2 - 2.5 8.2 14.8 63 3.8 0.0 6.2 6 1 0 6 6 6 0 C4-type zinc ribbon domain C1_4 PF07975.10 MSTRG.4999.1_2 - 3.3 7.9 24.6 6 7.1 2.0 5.6 1 1 5 7 7 7 0 TFIIH C1-like domain HNH_5 PF14279.4 MSTRG.4999.1_2 - 4.4 7.1 10.8 58 3.5 0.3 5.7 3 3 1 4 4 4 0 HNH endonuclease DUF3725 PF12523.6 MSTRG.4999.1_2 - 7.2 6.9 6.0 1.8e+02 2.4 0.0 4.5 2 2 2 4 4 4 0 Protein of unknown function (DUF3725) DND1_DSRM PF14709.5 MSTRG.11735.1_3 - 5.8e-18 64.8 0.1 9.3e-18 64.1 0.1 1.3 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 RRM_1 PF00076.20 MSTRG.11735.1_3 - 0.086 12.5 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SUIM_assoc PF16619.3 MSTRG.28548.1_2 - 0.014 15.4 4.2 0.026 14.5 4.2 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 zf-H2C2_2 PF13465.4 MSTRG.24727.1_1 - 1.6e-49 164.1 68.7 6.4e-08 32.6 0.4 11.4 11 0 0 11 11 11 8 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.24727.1_1 - 1.4e-39 132.2 90.4 0.00011 22.3 2.2 10.8 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.24727.1_1 - 2.6e-27 93.0 94.4 0.0013 19.3 1.3 11.1 11 0 0 11 11 10 10 C2H2-type zinc finger BTB PF00651.29 MSTRG.24727.1_1 - 3.1e-22 78.8 0.0 6e-22 77.8 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_jaz PF12171.6 MSTRG.24727.1_1 - 2e-16 59.7 58.2 0.0049 17.0 0.5 10.9 11 0 0 11 11 11 7 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.24727.1_1 - 9.1e-13 48.0 71.5 0.0017 18.6 1.6 10.8 10 0 0 10 10 10 7 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 MSTRG.24727.1_1 - 9.7e-05 22.1 75.3 0.016 15.0 2.1 10.8 10 1 0 10 10 10 4 C2H2-type zinc finger DUF3355 PF11835.6 MSTRG.24727.1_1 - 0.00079 19.1 0.6 0.0017 18.0 0.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3355) zinc_ribbon_15 PF17032.3 MSTRG.24727.1_1 - 0.0023 18.5 35.0 0.16 12.6 2.3 5.8 2 1 4 6 6 6 3 zinc-ribbon family zf-C2H2_8 PF15909.3 MSTRG.24727.1_1 - 0.0069 16.5 3.6 0.0069 16.5 3.6 5.6 1 1 5 6 6 6 2 C2H2-type zinc ribbon BolA PF01722.16 MSTRG.24727.1_1 - 0.014 15.5 18.9 2.5 8.3 3.1 5.4 3 1 2 5 5 5 0 BolA-like protein zf-C2H2_11 PF16622.3 MSTRG.24727.1_1 - 0.021 14.5 1.0 0.021 14.5 1.0 9.3 10 0 0 10 10 8 0 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 MSTRG.24727.1_1 - 0.082 12.9 46.2 0.32 11.0 2.1 7.5 4 3 4 8 8 8 0 Zinc ribbon domain DUF5005 PF16396.3 MSTRG.24727.1_1 - 0.11 11.0 0.0 0.18 10.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5005) ADK_lid PF05191.12 MSTRG.24727.1_1 - 0.25 11.3 23.5 1.4 8.9 0.5 5.9 4 1 1 5 5 5 0 Adenylate kinase, active site lid HypA PF01155.17 MSTRG.24727.1_1 - 0.57 10.1 32.5 6.1 6.8 0.7 5.9 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF2180 PF09947.7 MSTRG.24727.1_1 - 1.2 9.0 6.3 4.8 7.1 0.1 4.2 2 1 2 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2180) DZR PF12773.5 MSTRG.24727.1_1 - 5.8 6.9 39.2 7.7 6.5 1.9 5.5 2 1 0 2 2 1 0 Double zinc ribbon DUF3268 PF11672.6 MSTRG.24727.1_1 - 7.8 6.7 26.0 1.1 9.4 0.3 5.3 2 1 4 7 7 6 0 zinc-finger-containing domain Ribosomal_L32e PF01655.16 MSTRG.18531.1_3 - 9.4e-57 189.9 3.3 1.3e-56 189.5 3.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L32 DUF2324 PF10086.7 MSTRG.3998.3_2 - 0.042 13.1 0.0 0.055 12.7 0.0 1.2 1 0 0 1 1 1 0 Putative membrane peptidase family (DUF2324) ATP1G1_PLM_MAT8 PF02038.14 MSTRG.9084.2_3 - 4.8e-11 41.7 0.3 1.2e-10 40.4 0.3 1.6 1 0 0 1 1 1 1 ATP1G1/PLM/MAT8 family AAA_9 PF12781.5 MSTRG.13640.1_1 - 6.6e-58 195.3 0.0 1.5e-57 194.1 0.0 1.7 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 MT PF12777.5 MSTRG.13640.1_1 - 3.9e-51 174.0 5.9 5.3e-51 173.5 5.9 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_8 PF12780.5 MSTRG.13640.1_1 - 3.2e-22 78.9 0.0 4.6e-22 78.3 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 HAUS6_N PF14661.4 MSTRG.13640.1_1 - 0.2 11.1 12.8 1.3 8.4 3.7 2.3 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Spc7 PF08317.9 MSTRG.13640.1_1 - 0.51 9.0 16.5 0.37 9.5 2.1 2.5 2 0 0 2 2 2 0 Spc7 kinetochore protein ISG65-75 PF11727.6 MSTRG.13640.1_1 - 1 8.4 11.5 0.059 12.5 5.2 1.9 2 0 0 2 2 2 0 Invariant surface glycoprotein GAS PF13851.4 MSTRG.13640.1_1 - 1.6 7.9 15.7 0.27 10.4 2.0 2.5 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding LRRCT PF01463.22 MSTRG.29214.1_1 - 0.09 13.2 1.0 0.47 11.0 1.0 2.3 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain FA_desaturase PF00487.22 MSTRG.8652.1_2 - 5.8e-25 88.5 16.4 6.6e-25 88.3 15.1 1.6 2 0 0 2 2 2 1 Fatty acid desaturase Lipid_DES PF08557.8 MSTRG.8652.1_2 - 8.5e-21 73.0 0.2 1.8e-20 72.0 0.2 1.6 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) SRF-TF PF00319.16 MSTRG.4660.10_1 - 1.9e-23 81.5 0.4 3.9e-23 80.5 0.4 1.6 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.6 MSTRG.4660.10_1 - 1.4e-22 79.3 0.8 3.9e-22 77.9 0.8 1.8 1 0 0 1 1 1 1 Holliday junction regulator protein family C-terminal repeat K_channel_TID PF07941.9 MSTRG.4660.10_3 - 0.16 12.3 5.2 0.45 10.9 5.2 1.7 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain WSK PF03832.11 MSTRG.2059.2_3 - 6.5e-11 41.6 1.6 6.5e-11 41.6 1.6 5.1 4 0 0 4 4 4 2 WSK motif PRR18 PF15671.3 MSTRG.7730.4_2 - 2.4e-34 119.3 8.7 2.3e-22 80.0 0.6 2.2 1 1 1 2 2 2 2 Proline-rich protein family 18 Got1 PF04178.10 MSTRG.7730.4_2 - 1.7e-11 44.4 2.4 3.7e-11 43.3 2.4 1.5 1 0 0 1 1 1 1 Got1/Sft2-like family Got1 PF04178.10 MSTRG.7730.4_3 - 9.7e-17 61.3 5.4 1.8e-16 60.5 5.4 1.4 1 0 0 1 1 1 1 Got1/Sft2-like family MIG-14_Wnt-bd PF06664.10 MSTRG.12171.2_2 - 8.8e-70 235.1 14.1 8.8e-70 235.1 14.1 1.6 2 0 0 2 2 2 1 Wnt-binding factor required for Wnt secretion Myosin_head PF00063.19 MSTRG.3650.2_2 - 1.4e-252 839.6 0.9 1.8e-252 839.3 0.9 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.11 MSTRG.3650.2_2 - 1.6e-52 177.8 1.2 3.1e-52 176.8 1.2 1.5 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_9 PF14604.4 MSTRG.3650.2_2 - 8.9e-17 60.6 0.2 2.2e-16 59.3 0.2 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.3650.2_2 - 1e-15 56.9 0.4 3.4e-15 55.2 0.1 2.1 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 MSTRG.3650.2_2 - 1.3e-11 43.9 0.0 3.1e-11 42.7 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain AAA_16 PF13191.4 MSTRG.3650.2_2 - 0.011 16.0 0.0 0.044 14.0 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.4 MSTRG.3650.2_2 - 0.042 14.0 0.1 0.16 12.1 0.1 1.9 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.14 MSTRG.3650.2_2 - 0.051 13.3 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Sigma54_activat PF00158.24 MSTRG.3650.2_2 - 0.073 12.6 0.4 0.22 11.1 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain Microtub_bd PF16796.3 MSTRG.3650.2_2 - 0.083 12.7 0.2 0.65 9.8 0.0 2.3 2 0 0 2 2 2 0 Microtubule binding ABC_tran PF00005.25 MSTRG.3650.2_2 - 0.11 12.8 0.0 0.43 11.0 0.0 1.9 1 0 0 1 1 1 0 ABC transporter IQ PF00612.25 MSTRG.3650.2_2 - 0.39 10.5 2.4 1.4 8.7 2.4 2.0 1 0 0 1 1 1 0 IQ calmodulin-binding motif EGF_CA PF07645.13 MSTRG.650.1_1 - 5e-68 224.9 142.6 2.6e-10 40.2 6.3 11.4 11 0 0 11 11 11 9 Calcium-binding EGF domain cEGF PF12662.5 MSTRG.650.1_1 - 8.2e-58 191.8 63.7 1.1e-07 31.6 1.4 11.3 10 0 0 10 10 10 10 Complement Clr-like EGF-like TB PF00683.15 MSTRG.650.1_1 - 8.9e-17 60.4 18.7 4.1e-13 48.7 3.9 4.2 4 0 0 4 4 4 2 TB domain FXa_inhibition PF14670.4 MSTRG.650.1_1 - 2.6e-16 59.5 138.8 0.0028 17.8 3.2 11.9 7 1 4 11 11 11 8 Coagulation Factor Xa inhibitory site EGF PF00008.25 MSTRG.650.1_1 - 7.7e-14 51.6 139.8 0.00026 21.1 8.1 12.5 12 1 1 13 13 13 7 EGF-like domain hEGF PF12661.5 MSTRG.650.1_1 - 1.4e-12 47.7 134.7 0.00024 21.5 5.4 13.6 11 0 0 11 11 11 5 Human growth factor-like EGF EGF_3 PF12947.5 MSTRG.650.1_1 - 2.8e-05 24.1 102.8 0.0068 16.4 2.9 11.4 8 1 2 10 10 10 5 EGF domain EGF_2 PF07974.11 MSTRG.650.1_1 - 0.0029 17.8 5.3 0.0029 17.8 5.3 11.9 10 2 0 11 11 11 4 EGF-like domain EGF_MSP1_1 PF12946.5 MSTRG.650.1_1 - 0.008 16.1 5.0 0.008 16.1 5.0 10.6 10 0 0 10 10 10 6 MSP1 EGF domain 1 Macoilin PF09726.7 MSTRG.650.1_1 - 1.2 7.4 7.5 1.7 7.0 7.5 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF1388 PF07142.10 MSTRG.650.1_2 - 0.017 14.9 15.3 1.8 8.5 2.0 4.9 3 1 0 3 3 3 0 Repeat of unknown function (DUF1388) WSK PF03832.11 MSTRG.2059.1_3 - 6.7e-11 41.5 1.6 6.7e-11 41.5 1.6 5.2 4 0 0 4 4 4 2 WSK motif Atrophin-1 PF03154.13 MSTRG.17690.1_1 - 0.053 11.7 4.4 0.078 11.1 4.4 1.1 1 0 0 1 1 1 0 Atrophin-1 family Acyl-CoA_dh_1 PF00441.22 MSTRG.17690.1_2 - 9e-39 132.9 0.1 2.3e-38 131.6 0.0 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.14 MSTRG.17690.1_2 - 5e-37 126.9 0.1 8e-37 126.2 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.17 MSTRG.17690.1_2 - 1.1e-26 92.7 0.0 1.9e-26 92.0 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.9 MSTRG.17690.1_2 - 4.2e-09 36.6 0.0 7.5e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Atrophin-1 PF03154.13 MSTRG.17690.1_3 - 0.01 14.0 3.9 0.014 13.6 3.9 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.4 MSTRG.17690.1_3 - 0.33 10.8 8.0 0.55 10.1 8.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) EF-hand_1 PF00036.30 MSTRG.29118.1_1 - 3.1e-42 138.9 10.6 5.5e-10 37.9 0.1 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 MSTRG.29118.1_1 - 2.3e-35 120.8 3.9 5.2e-18 65.2 1.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 MSTRG.29118.1_1 - 1.7e-31 107.6 11.5 7.1e-15 54.4 0.7 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.29118.1_1 - 2.5e-30 101.7 4.9 1.1e-09 37.3 0.1 4.4 4 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.4 MSTRG.29118.1_1 - 4.4e-27 92.2 8.3 3.4e-07 29.4 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.4 MSTRG.29118.1_1 - 8.5e-15 54.7 0.2 2.3e-09 37.3 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 MSTRG.29118.1_1 - 4.7e-09 36.0 0.9 8.3e-05 22.3 0.2 2.4 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 MSTRG.29118.1_1 - 5.7e-08 32.9 0.0 0.0027 17.9 0.1 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.9 MSTRG.29118.1_1 - 3.9e-07 30.8 0.0 0.00012 22.7 0.1 2.0 1 1 1 2 2 2 1 EF-hand domain UPF0154 PF03672.11 MSTRG.29118.1_1 - 1.2e-05 25.1 0.0 0.042 13.8 0.0 3.0 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.8 MSTRG.29118.1_1 - 0.00028 20.8 0.2 0.00092 19.1 0.1 1.9 2 1 0 2 2 2 1 Ca2+ insensitive EF hand DUF1103 PF06513.9 MSTRG.29118.1_1 - 0.00048 19.7 1.6 0.00056 19.5 1.6 1.1 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) TerB PF05099.11 MSTRG.29118.1_1 - 0.00055 19.8 0.4 0.52 10.1 0.0 2.1 1 1 1 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.11 MSTRG.29118.1_1 - 0.0018 18.1 1.1 0.74 9.6 0.0 3.4 1 1 3 4 4 4 1 Caleosin related protein RNA_pol_Rpb4 PF03874.14 MSTRG.29118.1_1 - 0.0032 17.7 0.7 1.4 9.2 0.1 2.5 3 0 0 3 3 3 1 RNA polymerase Rpb4 DUF4497 PF14924.4 MSTRG.29118.1_1 - 0.0072 16.6 0.0 0.54 10.6 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF4497) SurA_N_2 PF13623.4 MSTRG.29118.1_1 - 0.0081 15.9 0.6 0.37 10.5 0.1 2.2 1 1 1 2 2 2 1 SurA N-terminal domain Poly_export PF02563.14 MSTRG.29118.1_1 - 0.021 14.9 0.1 0.86 9.7 0.0 2.8 2 1 1 3 3 3 0 Polysaccharide biosynthesis/export protein MotA_activ PF09114.8 MSTRG.29118.1_1 - 0.036 14.0 0.2 0.56 10.2 0.0 2.3 1 1 0 2 2 2 0 Transcription factor MotA, activation domain SurA_N_3 PF13624.4 MSTRG.29118.1_1 - 0.063 12.9 0.3 0.3 10.7 0.2 1.8 1 1 1 2 2 2 0 SurA N-terminal domain Spore_III_AB PF09548.8 MSTRG.29118.1_1 - 0.12 12.4 0.1 0.16 11.9 0.1 1.2 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) RRM_1 PF00076.20 MSTRG.23122.2_3 - 4e-16 58.4 0.0 6e-16 57.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 MSTRG.23122.2_3 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Lysyl_oxidase PF01186.15 MSTRG.24826.1_3 - 4e-90 300.8 0.8 5.3e-90 300.4 0.8 1.2 1 0 0 1 1 1 1 Lysyl oxidase CARDB PF07705.9 MSTRG.24826.1_3 - 0.02 15.0 0.0 0.1 12.8 0.0 2.0 2 0 0 2 2 2 0 CARDB HECT PF00632.23 MSTRG.17312.1_1 - 3.6e-101 338.6 0.1 4.6e-101 338.2 0.1 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.24 MSTRG.17312.1_1 - 3.4e-47 157.9 20.9 4.4e-13 48.8 0.2 4.6 4 0 0 4 4 4 4 WW domain C2 PF00168.28 MSTRG.17312.1_1 - 4.9e-22 78.0 0.0 1e-21 77.0 0.0 1.5 1 0 0 1 1 1 1 C2 domain Ig_3 PF13927.4 MSTRG.27942.1_1 - 2.8e-19 69.4 0.1 1.7e-10 41.2 0.2 2.1 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 MSTRG.27942.1_1 - 6e-17 61.5 0.1 8e-13 48.2 0.1 2.1 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 MSTRG.27942.1_1 - 1.4e-15 57.0 0.0 6.8e-08 32.3 0.0 2.1 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.27942.1_1 - 1.3e-09 38.1 0.1 1e-07 32.1 0.1 2.2 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.15 MSTRG.27942.1_1 - 1.3e-07 31.6 0.3 0.0004 20.4 0.2 3.2 2 2 0 2 2 2 1 Immunoglobulin V-set domain C1-set PF07654.13 MSTRG.27942.1_1 - 5.1e-05 23.5 0.0 0.0087 16.4 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin C1-set domain C2-set_2 PF08205.10 MSTRG.27942.1_1 - 9.6e-05 22.3 0.4 0.0054 16.7 0.1 2.1 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 MSTRG.27942.1_1 - 0.016 15.1 0.0 0.053 13.4 0.0 1.8 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain Ig_5 PF16681.3 MSTRG.27942.1_1 - 0.085 13.1 0.2 7 7.0 0.1 2.9 2 1 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ribosomal_S7 PF00177.19 MSTRG.7909.3_1 - 1.2e-36 125.5 0.9 1.6e-36 125.1 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e FOXP-CC PF16159.3 MSTRG.13060.4_1 - 7e-34 116.1 4.0 7e-34 116.1 4.0 3.6 2 1 1 3 3 3 1 FOXP coiled-coil domain Forkhead PF00250.16 MSTRG.13060.4_1 - 3.1e-28 97.8 0.8 6e-28 96.9 0.2 1.9 2 0 0 2 2 2 1 Forkhead domain ALMT PF11744.6 MSTRG.13060.4_1 - 0.21 10.2 5.0 0.53 8.9 5.0 1.6 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4298 PF14131.4 MSTRG.13060.4_1 - 3.2 7.6 15.5 1.4 8.8 11.8 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4298) adh_short PF00106.23 MSTRG.23655.1_3 - 1.4e-20 73.5 0.0 2.6e-19 69.3 0.0 2.2 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 MSTRG.23655.1_3 - 2.4e-10 40.2 0.0 0.00016 21.1 0.0 2.2 1 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 MSTRG.23655.1_3 - 0.00021 21.1 0.0 0.00033 20.5 0.0 1.2 1 0 0 1 1 1 1 KR domain COX4 PF02936.12 MSTRG.23158.2_2 - 1.9e-57 193.0 0.8 2.4e-57 192.7 0.8 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV hSac2 PF12456.6 MSTRG.23938.1_1 - 5e-25 87.3 0.0 7.8e-25 86.7 0.0 1.3 1 0 0 1 1 1 1 Inositol phosphatase Ribosomal_60s PF00428.17 MSTRG.23938.1_1 - 2.5 8.6 9.7 3.1 8.3 7.4 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein SARG PF15385.4 MSTRG.20327.6_3 - 2.4e-48 165.7 21.9 1e-37 130.5 17.7 2.4 2 0 0 2 2 2 2 Specifically androgen-regulated gene protein T2SSM_b PF10741.7 MSTRG.20327.6_3 - 0.15 11.7 0.0 0.35 10.5 0.0 1.6 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M subtype b Trypan_PARP PF05887.9 MSTRG.20327.6_3 - 0.58 10.1 13.1 0.033 14.1 7.3 1.9 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Septin PF00735.16 MSTRG.2532.1_2 - 8.6e-111 369.5 2.6 1.1e-110 369.2 2.6 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 MSTRG.2532.1_2 - 2e-08 34.1 0.0 3.7e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 MSTRG.2532.1_2 - 4.2e-06 26.6 0.3 4.6e-05 23.3 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 MSTRG.2532.1_2 - 1.6e-05 24.4 1.2 0.00039 19.9 0.2 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AIG1 PF04548.14 MSTRG.2532.1_2 - 3.4e-05 23.1 0.2 5.7e-05 22.4 0.2 1.3 1 0 0 1 1 1 1 AIG1 family Roc PF08477.11 MSTRG.2532.1_2 - 0.00018 21.6 0.2 0.00035 20.7 0.2 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 MSTRG.2532.1_2 - 0.00096 19.4 0.0 0.0019 18.5 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain Ras PF00071.20 MSTRG.2532.1_2 - 0.0016 17.9 0.1 0.003 17.0 0.1 1.4 1 0 0 1 1 1 1 Ras family Dynamin_N PF00350.21 MSTRG.2532.1_2 - 0.0025 17.7 2.0 0.14 12.1 0.5 2.4 1 1 1 2 2 2 1 Dynamin family AAA_22 PF13401.4 MSTRG.2532.1_2 - 0.0066 16.6 0.0 0.013 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.25 MSTRG.2532.1_2 - 0.015 15.7 0.0 0.039 14.3 0.0 1.6 1 0 0 1 1 1 0 ABC transporter NB-ARC PF00931.20 MSTRG.2532.1_2 - 0.023 13.6 0.2 0.034 13.1 0.2 1.2 1 0 0 1 1 1 0 NB-ARC domain G-alpha PF00503.18 MSTRG.2532.1_2 - 0.024 13.7 1.3 0.06 12.4 1.2 1.6 1 1 0 1 1 1 0 G-protein alpha subunit AAA_14 PF13173.4 MSTRG.2532.1_2 - 0.049 13.5 0.1 0.098 12.6 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.4 MSTRG.2532.1_2 - 0.052 13.1 0.2 0.12 11.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.16 MSTRG.2532.1_2 - 0.052 12.8 0.0 0.088 12.0 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.4 MSTRG.2532.1_2 - 0.062 12.9 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma54_activat PF00158.24 MSTRG.2532.1_2 - 0.082 12.5 0.1 0.14 11.7 0.1 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain IIGP PF05049.11 MSTRG.2532.1_2 - 0.087 11.7 0.3 0.18 10.7 0.0 1.5 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) Ank_2 PF12796.5 MSTRG.3528.1_1 - 1.6e-23 83.0 0.4 3.8e-11 43.3 0.1 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.28 MSTRG.3528.1_1 - 4.8e-18 64.6 4.3 0.00038 20.6 0.3 6.1 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.4 MSTRG.3528.1_1 - 2.2e-17 61.2 1.9 0.076 13.5 0.1 6.4 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.4 MSTRG.3528.1_1 - 2.8e-17 62.7 6.0 1.4e-06 28.6 0.1 5.1 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.4 MSTRG.3528.1_1 - 3e-15 56.0 4.8 1.5e-05 25.1 0.1 5.4 3 1 2 5 5 5 4 Ankyrin repeats (many copies) SOCS_box PF07525.14 MSTRG.3528.1_1 - 7.6e-09 35.7 0.9 1.6e-08 34.6 0.9 1.6 1 0 0 1 1 1 1 SOCS box PH PF00169.27 MSTRG.4582.6_1 - 5.8e-10 39.5 0.0 1e-09 38.7 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 MSTRG.4582.6_1 - 0.00051 20.3 0.2 0.001 19.3 0.2 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.4 MSTRG.4582.6_1 - 0.0015 18.6 0.1 0.0036 17.4 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain zf-C2H2 PF00096.24 MSTRG.10485.1_2 - 2.9e-12 46.2 29.1 0.00018 21.6 8.9 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.10485.1_2 - 7.1e-09 35.6 14.0 6.6e-06 26.2 6.6 3.6 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.10485.1_2 - 1.2e-05 25.6 25.6 0.016 15.9 6.4 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_8 PF15909.3 MSTRG.10485.1_2 - 0.16 12.1 6.1 0.67 10.1 5.7 2.3 2 0 0 2 2 2 0 C2H2-type zinc ribbon LIM PF00412.20 MSTRG.22872.1_1 - 0.54 10.4 13.5 1.3 9.2 13.5 1.7 1 0 0 1 1 1 0 LIM domain zf-C2H2 PF00096.24 MSTRG.5576.3_1 - 1.4e-20 72.3 66.1 0.0038 17.5 0.7 9.4 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.5576.3_1 - 2.2e-12 46.7 68.8 0.0015 18.7 2.3 9.0 10 0 0 10 10 10 7 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.5576.3_1 - 1.4e-11 44.1 66.1 0.011 16.3 2.2 9.6 9 0 0 9 9 9 6 C2H2-type zinc finger zf-met PF12874.5 MSTRG.5576.3_1 - 0.01 16.1 22.9 0.52 10.6 1.8 6.2 6 0 0 6 6 6 0 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.3 MSTRG.5576.3_1 - 0.015 15.5 30.3 1.3 9.2 1.5 5.2 1 1 4 5 5 5 0 C2H2-type zinc ribbon Ta0938 PF11494.6 MSTRG.5576.3_1 - 0.018 15.2 10.4 0.054 13.7 0.1 3.7 2 1 2 4 4 4 0 Ta0938 Peptidase_M10 PF00413.22 MSTRG.18402.1_1 - 5e-54 182.3 1.2 1e-53 181.3 1.2 1.5 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 MSTRG.18402.1_1 - 6.8e-50 166.6 23.7 5e-14 51.8 1.2 4.5 4 0 0 4 4 4 4 Hemopexin DUF3377 PF11857.6 MSTRG.18402.1_1 - 7.6e-29 99.3 1.4 2e-28 98.0 1.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) PG_binding_1 PF01471.16 MSTRG.18402.1_1 - 5.2e-11 42.5 0.3 8.8e-11 41.7 0.3 1.4 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.22 MSTRG.18402.1_1 - 0.0024 17.4 0.6 1 8.8 0.2 2.3 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Metallopep PF12044.6 MSTRG.18402.1_1 - 0.03 12.8 1.2 0.045 12.2 1.2 1.1 1 0 0 1 1 1 0 Putative peptidase family DUF912 PF06024.10 MSTRG.18402.1_1 - 0.067 13.4 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) TMEM154 PF15102.4 MSTRG.18402.1_1 - 0.18 11.6 0.1 0.38 10.5 0.1 1.4 1 0 0 1 1 1 0 TMEM154 protein family RRM_1 PF00076.20 MSTRG.25436.2_3 - 4.5e-32 109.5 0.1 4.9e-15 55.0 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.25436.2_3 - 6.6e-11 42.0 0.2 1.4e-05 24.9 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.4 MSTRG.25436.2_3 - 0.0086 15.9 1.9 1.6 8.7 0.2 2.9 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.9 MSTRG.25436.2_3 - 0.058 13.3 0.3 0.18 11.7 0.2 1.7 2 0 0 2 2 2 0 RNA binding motif HAD_2 PF13419.4 MSTRG.25285.1_3 - 5.3e-24 85.1 0.0 6.4e-24 84.9 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.24 MSTRG.25285.1_3 - 1.5e-11 44.8 0.0 4.2e-10 40.1 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.4 MSTRG.25285.1_3 - 0.023 14.7 0.1 0.25 11.3 0.1 2.5 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase TMEM154 PF15102.4 MSTRG.9085.3_1 - 0.019 14.7 0.1 0.033 14.0 0.1 1.3 1 0 0 1 1 1 0 TMEM154 protein family RhoGEF PF00621.18 MSTRG.22358.1_2 - 1.3e-37 129.7 1.4 1.3e-37 129.7 1.4 2.4 3 0 0 3 3 3 1 RhoGEF domain PH PF00169.27 MSTRG.22358.1_2 - 6.5e-10 39.3 0.4 1.6e-09 38.0 0.4 1.7 1 0 0 1 1 1 1 PH domain CRAL_TRIO_2 PF13716.4 MSTRG.22358.1_2 - 3.1e-08 33.7 0.0 7.9e-08 32.4 0.0 1.7 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain SH3_1 PF00018.26 MSTRG.22358.1_2 - 3.8e-05 23.1 0.1 0.00011 21.6 0.1 1.8 1 0 0 1 1 1 1 SH3 domain PH_10 PF15411.4 MSTRG.22358.1_2 - 0.0017 18.5 0.1 0.0042 17.2 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain Serpin PF00079.18 MSTRG.22358.1_2 - 0.068 12.3 0.1 0.14 11.3 0.1 1.4 1 0 0 1 1 1 0 Serpin (serine protease inhibitor) SH3_9 PF14604.4 MSTRG.22358.1_2 - 0.16 11.7 0.0 0.84 9.4 0.1 2.2 2 0 0 2 2 2 0 Variant SH3 domain HBM PF16591.3 MSTRG.22358.1_2 - 0.19 11.0 3.4 0.13 11.5 0.6 2.0 2 0 0 2 2 2 0 Helical bimodular sensor domain Spectrin PF00435.19 MSTRG.22358.1_2 - 8.8 6.7 14.5 0.87 10.0 0.5 4.0 2 1 2 4 4 4 0 Spectrin repeat TMEM219 PF14940.4 MSTRG.981.1_2 - 1e-85 287.0 0.1 1.8e-85 286.2 0.1 1.4 1 0 0 1 1 1 1 Transmembrane 219 ETRAMP PF09716.8 MSTRG.981.1_2 - 0.031 14.2 1.7 0.55 10.2 0.5 2.7 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Cadherin PF00028.15 MSTRG.10364.1_3 - 1.4e-72 240.1 3.7 4e-18 65.5 0.0 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C_2 PF16492.3 MSTRG.10364.1_3 - 4.5e-29 100.9 0.3 1.7e-28 99.1 0.3 2.1 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 MSTRG.10364.1_3 - 0.00026 20.9 5.2 0.11 12.4 0.3 4.5 3 1 1 4 4 4 2 Cadherin-like Cadherin_tail PF15974.3 MSTRG.10364.1_3 - 0.0017 18.6 3.1 0.0017 18.6 3.1 2.2 2 0 0 2 2 2 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region IP_trans PF02121.16 MSTRG.24695.2_3 - 3.7e-117 390.1 2.5 4.9e-117 389.7 2.5 1.1 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein ABC_tran PF00005.25 MSTRG.13306.2_1 - 5.2e-48 162.9 0.0 2.8e-24 86.0 0.0 2.8 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.5 MSTRG.13306.2_1 - 3.8e-22 78.0 4.7 3.8e-22 78.0 4.7 3.9 6 0 0 6 6 3 1 ABC transporter AAA_21 PF13304.4 MSTRG.13306.2_1 - 2.3e-17 63.7 0.1 0.00011 22.0 0.0 4.2 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.17 MSTRG.13306.2_1 - 3.5e-07 29.8 0.9 0.95 8.7 0.0 3.7 2 2 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.4 MSTRG.13306.2_1 - 7e-07 28.7 0.5 0.002 17.7 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_33 PF13671.4 MSTRG.13306.2_1 - 2.8e-05 24.2 0.0 0.041 13.9 0.0 2.9 3 0 0 3 3 3 1 AAA domain DUF258 PF03193.14 MSTRG.13306.2_1 - 0.00018 21.3 0.0 0.0057 16.4 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 MSTRG.13306.2_1 - 0.00032 20.6 0.0 0.061 13.3 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.4 MSTRG.13306.2_1 - 0.00091 19.5 0.0 0.16 12.2 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_28 PF13521.4 MSTRG.13306.2_1 - 0.00099 19.2 0.1 0.89 9.6 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_18 PF13238.4 MSTRG.13306.2_1 - 0.0011 19.3 0.5 0.23 11.8 0.0 3.2 3 1 0 3 3 2 1 AAA domain AAA PF00004.27 MSTRG.13306.2_1 - 0.0014 18.9 0.1 0.93 9.8 0.1 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.4 MSTRG.13306.2_1 - 0.0017 17.9 0.0 0.37 10.3 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.4 MSTRG.13306.2_1 - 0.0018 18.4 0.0 0.41 10.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.4 MSTRG.13306.2_1 - 0.0066 15.9 0.0 0.61 9.5 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_14 PF13173.4 MSTRG.13306.2_1 - 0.0067 16.3 0.0 0.72 9.8 0.0 3.2 3 0 0 3 3 2 1 AAA domain Dynamin_N PF00350.21 MSTRG.13306.2_1 - 0.0068 16.3 0.3 0.19 11.6 0.0 3.3 4 0 0 4 4 4 1 Dynamin family AAA_27 PF13514.4 MSTRG.13306.2_1 - 0.0071 15.8 0.9 2.5 7.5 0.0 3.3 3 0 0 3 3 3 1 AAA domain NACHT PF05729.10 MSTRG.13306.2_1 - 0.0084 15.9 1.2 0.57 10.0 0.0 2.9 3 0 0 3 3 3 1 NACHT domain AAA_24 PF13479.4 MSTRG.13306.2_1 - 0.01 15.4 1.2 1.1 8.9 0.0 3.6 4 0 0 4 4 4 0 AAA domain AAA_15 PF13175.4 MSTRG.13306.2_1 - 0.013 15.0 0.0 0.013 15.0 0.0 3.9 5 0 0 5 5 5 0 AAA ATPase domain AAA_23 PF13476.4 MSTRG.13306.2_1 - 0.024 15.0 0.0 0.024 15.0 0.0 4.3 5 0 0 5 5 4 0 AAA domain RNA_helicase PF00910.20 MSTRG.13306.2_1 - 0.044 14.0 0.0 0.52 10.6 0.0 2.4 2 0 0 2 2 2 0 RNA helicase IstB_IS21 PF01695.15 MSTRG.13306.2_1 - 0.048 13.3 0.0 8.2 6.0 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_5 PF07728.12 MSTRG.13306.2_1 - 0.051 13.4 0.2 9.3 6.1 0.2 2.7 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) ArgK PF03308.14 MSTRG.13306.2_1 - 0.061 12.2 1.9 3.9 6.2 0.0 2.9 3 0 0 3 3 3 0 ArgK protein DUF87 PF01935.15 MSTRG.13306.2_1 - 0.29 11.0 1.8 1.1 9.1 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function DUF87 Rop PF01815.14 MSTRG.13306.2_1 - 0.33 10.7 7.6 0.19 11.5 0.2 2.9 2 1 1 3 3 3 0 Rop protein MukB PF04310.10 MSTRG.13306.2_1 - 0.55 9.9 3.2 0.78 9.4 0.0 2.7 4 0 0 4 4 4 0 MukB N-terminal WD40 PF00400.30 MSTRG.11706.2_1 - 2.7e-11 43.7 7.1 0.00076 20.1 0.2 5.1 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.11706.2_1 - 0.00061 19.9 0.5 0.14 12.3 0.0 3.0 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.3 MSTRG.11706.2_1 - 0.031 13.1 0.0 0.054 12.3 0.0 1.4 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain zf-H2C2_2 PF13465.4 MSTRG.1610.1_3 - 2.2e-110 356.5 99.4 2e-08 34.1 1.6 15.5 15 0 0 15 15 15 15 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.1610.1_3 - 4.9e-63 206.1 125.9 2.7e-06 27.4 2.6 15.6 15 0 0 15 15 15 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.1610.1_3 - 2.1e-49 161.7 126.3 0.00044 20.7 1.7 16.4 17 0 0 17 17 16 15 C2H2-type zinc finger zf-H2C2_5 PF13909.4 MSTRG.1610.1_3 - 7.1e-13 47.9 75.4 0.022 14.3 0.6 14.7 15 0 0 15 15 15 8 C2H2-type zinc-finger domain zinc_ribbon_15 PF17032.3 MSTRG.1610.1_3 - 6.1e-11 42.8 47.2 0.24 12.1 1.1 8.5 1 1 5 9 9 9 7 zinc-ribbon family zf-met PF12874.5 MSTRG.1610.1_3 - 1.2e-10 41.3 100.8 0.064 13.5 1.9 14.4 14 0 0 14 14 14 9 Zinc-finger of C2H2 type zf-LYAR PF08790.9 MSTRG.1610.1_3 - 3e-08 33.3 83.8 0.041 13.7 0.6 14.6 15 0 0 15 15 15 9 LYAR-type C2HC zinc finger HypA PF01155.17 MSTRG.1610.1_3 - 1.6e-07 31.1 46.3 0.14 12.0 0.2 8.9 1 1 9 10 10 10 7 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_11 PF16622.3 MSTRG.1610.1_3 - 1.9e-06 27.4 90.4 0.002 17.7 0.3 13.7 14 0 0 14 14 13 7 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 MSTRG.1610.1_3 - 5.9e-06 26.2 62.7 0.17 11.9 2.0 10.2 3 3 10 13 13 13 8 Zinc ribbon domain LIM PF00412.20 MSTRG.1610.1_3 - 6.7e-05 22.9 71.2 0.47 10.6 0.7 12.6 2 1 11 13 13 13 3 LIM domain zf-C2HE PF16278.3 MSTRG.1610.1_3 - 8.8e-05 22.8 97.5 1.5 9.2 1.4 15.5 2 1 14 16 16 15 3 C2HE / C2H2 / C2HC zinc-binding finger MBD PF01429.17 MSTRG.1610.1_3 - 0.11 12.0 5.3 23 4.6 0.4 6.0 2 1 1 4 4 4 0 Methyl-CpG binding domain zf-trcl PF13451.4 MSTRG.1610.1_3 - 0.21 11.4 66.3 11 5.9 0.1 13.8 14 1 0 14 14 14 0 Probable zinc-ribbon domain zf-C2H2_6 PF13912.4 MSTRG.1610.1_3 - 0.33 10.8 97.0 0.061 13.2 1.0 15.3 15 1 0 15 15 14 0 C2H2-type zinc finger zf-HYPF PF07503.10 MSTRG.1610.1_3 - 0.36 10.5 59.7 17 5.1 0.1 13.9 14 1 1 15 15 14 0 HypF finger Elf1 PF05129.11 MSTRG.1610.1_3 - 0.49 10.4 63.8 0.25 11.3 1.8 9.3 1 1 12 13 13 13 0 Transcription elongation factor Elf1 like zf-Sec23_Sec24 PF04810.13 MSTRG.1610.1_3 - 3.5 7.6 45.0 8.5 6.4 0.0 12.7 12 3 2 14 14 14 0 Sec23/Sec24 zinc finger CNRIP1 PF15043.4 MSTRG.1610.1_3 - 6.4 6.2 8.6 23 4.4 0.1 5.1 3 2 2 7 7 7 0 CB1 cannabinoid receptor-interacting protein 1 OTU PF02338.17 MSTRG.9301.3_2 - 1e-12 48.5 0.0 1.9e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.7 MSTRG.9301.3_2 - 4.5e-05 22.9 0.0 0.064 12.6 0.0 2.2 2 0 0 2 2 2 2 Peptidase C65 Otubain CBS PF00571.26 MSTRG.8088.2_2 - 2.7e-10 40.4 0.3 0.00014 22.1 0.1 2.6 2 0 0 2 2 2 2 CBS domain Lig_chan PF00060.24 MSTRG.16033.1_2 - 3.7e-52 176.0 0.1 5e-52 175.6 0.1 1.2 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 MSTRG.16033.1_2 - 2.6e-41 140.2 0.1 4.3e-41 139.6 0.1 1.3 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 MSTRG.16033.1_2 - 1.4e-18 67.0 0.0 2.7e-18 66.1 0.0 1.4 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Ion_trans_2 PF07885.14 MSTRG.16033.1_2 - 0.22 11.4 3.3 2.5 8.0 0.3 2.7 2 0 0 2 2 2 0 Ion channel Pkinase_Tyr PF07714.15 MSTRG.23295.4_3 - 7.3e-80 267.9 0.0 9.4e-80 267.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.23295.4_3 - 3.1e-38 131.5 0.0 3.3e-37 128.2 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Mid2 PF04478.10 MSTRG.23295.4_3 - 0.094 12.4 0.2 0.21 11.3 0.2 1.5 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor zf-C2H2 PF00096.24 MSTRG.3239.3_3 - 7e-31 104.8 133.2 0.0004 20.6 0.4 14.2 14 0 0 14 14 14 12 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.3239.3_3 - 7.3e-29 98.8 100.5 8.8e-09 35.3 0.0 14.4 14 0 0 14 14 14 9 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.3239.3_3 - 4.3e-25 86.1 128.9 0.0018 18.8 0.6 14.5 14 0 0 14 14 14 13 C2H2-type zinc finger zf-met PF12874.5 MSTRG.3239.3_3 - 2.1e-11 43.7 85.3 0.0082 16.4 2.9 12.5 12 0 0 12 12 12 7 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.3239.3_3 - 5.2e-09 36.0 100.4 0.018 15.2 3.5 13.3 12 1 1 13 13 13 7 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 MSTRG.3239.3_3 - 0.00035 20.3 4.6 0.00035 20.3 4.6 12.0 13 0 0 13 13 13 6 C2H2-type zinc finger GAGA PF09237.9 MSTRG.3239.3_3 - 0.03 14.0 9.7 5.9 6.7 1.0 4.0 3 0 0 3 3 3 0 GAGA factor BolA PF01722.16 MSTRG.3239.3_3 - 0.11 12.6 0.1 0.11 12.6 0.1 5.6 5 2 1 6 6 6 0 BolA-like protein CARD PF00619.19 MSTRG.3239.3_3 - 0.16 11.9 0.7 34 4.4 0.0 3.5 4 0 0 4 4 4 0 Caspase recruitment domain zf-C2H2_2 PF12756.5 MSTRG.3239.3_3 - 0.24 11.6 85.9 0.23 11.7 0.8 10.3 4 2 7 11 11 11 0 C2H2 type zinc-finger (2 copies) BRCT PF00533.24 MSTRG.6850.8_2 - 3.1e-20 72.2 0.0 2.3e-11 43.8 0.0 2.4 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.3 MSTRG.6850.8_2 - 2.1e-16 60.0 0.0 2.3e-09 37.4 0.0 2.3 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.5 MSTRG.6850.8_2 - 8.8e-12 44.7 0.0 2.5e-09 36.8 0.0 2.3 2 0 0 2 2 2 2 twin BRCT domain LIG3_BRCT PF16759.3 MSTRG.6850.8_2 - 3.9e-06 26.9 0.0 0.00012 22.2 0.0 2.3 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain SLC12 PF03522.13 MSTRG.6850.8_2 - 1 8.2 4.0 0.55 9.1 2.0 1.3 1 1 0 1 1 1 0 Solute carrier family 12 DUF966 PF06136.11 MSTRG.6850.8_2 - 8 5.9 14.9 7 6.1 8.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF966) DUF3456 PF11938.6 MSTRG.14154.1_1 - 1.6e-37 129.3 2.1 2e-37 129.0 2.1 1.1 1 0 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP Steroid_dh PF02544.14 MSTRG.12944.1_2 - 1.5e-22 80.1 0.6 1.7e-22 79.9 0.6 1.1 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase Peptidase_C1 PF00112.21 MSTRG.17062.1_2 - 1.2e-61 208.5 0.4 2.1e-61 207.7 0.4 1.4 1 0 0 1 1 1 1 Papain family cysteine protease CathepsinC_exc PF08773.9 MSTRG.17062.1_2 - 1.8e-46 157.2 1.7 3.1e-46 156.5 1.7 1.4 1 0 0 1 1 1 1 Cathepsin C exclusion domain Peptidase_C1_2 PF03051.13 MSTRG.17062.1_2 - 0.0052 15.5 2.3 0.0096 14.6 0.1 2.1 3 0 0 3 3 3 1 Peptidase C1-like family Propeptide_C1 PF08127.11 MSTRG.17062.1_2 - 0.11 12.3 0.0 0.3 10.9 0.0 1.7 1 0 0 1 1 1 0 Peptidase family C1 propeptide CAF1-p150_N PF15557.4 MSTRG.23660.1_2 - 2.7e-09 37.2 0.3 1.8e-08 34.5 0.2 2.1 1 1 0 1 1 1 1 CAF1 complex subunit p150, region binding to PCNA CPSF100_C PF13299.4 MSTRG.19309.1_2 - 0.21 11.6 1.9 0.27 11.3 1.9 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal TMEM126 PF07114.9 MSTRG.7595.1_1 - 0.036 13.4 0.2 0.057 12.7 0.2 1.2 1 0 0 1 1 1 0 Transmembrane protein 126 TMF_TATA_bd PF12325.6 MSTRG.26181.2_1 - 4.4e-30 104.1 15.4 4.4e-30 104.1 15.4 3.2 3 1 0 3 3 3 1 TATA element modulatory factor 1 TATA binding ATG16 PF08614.9 MSTRG.26181.2_1 - 0.0011 19.1 14.4 0.0011 19.1 14.4 2.2 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) Nucleoporin_FG2 PF15967.3 MSTRG.7113.2_1 - 3.2e-150 501.4 16.0 3.6e-150 501.2 16.0 1.0 1 0 0 1 1 1 1 Nucleoporin FG repeated region Mnd1 PF03962.13 MSTRG.7113.2_1 - 0.0061 16.3 1.7 0.0085 15.8 1.7 1.1 1 0 0 1 1 1 1 Mnd1 family PBC PF03792.11 MSTRG.7113.2_1 - 0.24 11.0 1.5 0.33 10.6 1.5 1.1 1 0 0 1 1 1 0 PBC domain EMP24_GP25L PF01105.22 MSTRG.24705.2_2 - 1.3e-46 158.7 0.0 1.7e-46 158.3 0.0 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD TerD PF02342.16 MSTRG.24705.2_2 - 0.12 11.7 0.1 0.17 11.2 0.1 1.2 1 0 0 1 1 1 0 TerD domain Bacillus_HBL PF05791.9 MSTRG.20227.1_1 - 0.0036 16.9 10.9 0.53 9.9 0.3 2.9 2 1 0 2 2 2 2 Bacillus haemolytic enterotoxin (HBL) EssA PF10661.7 MSTRG.20227.1_1 - 0.17 11.6 4.1 0.27 11.0 3.1 1.8 1 1 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA Reo_sigmaC PF04582.10 MSTRG.20227.1_1 - 0.46 9.7 8.5 2.4 7.3 3.8 2.9 1 1 2 3 3 3 0 Reovirus sigma C capsid protein SlyX PF04102.10 MSTRG.20227.1_1 - 3.8 8.1 28.8 3.8 8.1 1.3 4.9 4 0 0 4 4 4 0 SlyX MscS_porin PF12795.5 MSTRG.20227.1_1 - 5.7 6.3 44.3 0.081 12.3 28.3 3.1 2 1 1 3 3 3 0 Mechanosensitive ion channel porin domain Lysyl_oxidase PF01186.15 MSTRG.5025.1_1 - 1.3e-07 31.4 0.0 1.4e-07 31.2 0.0 1.1 1 0 0 1 1 1 1 Lysyl oxidase EF-hand_1 PF00036.30 MSTRG.14649.1_2 - 8.3e-41 134.4 9.6 2.3e-09 36.0 0.4 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 MSTRG.14649.1_2 - 5.2e-35 119.6 2.7 4.6e-18 65.3 0.7 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 MSTRG.14649.1_2 - 1.5e-32 111.0 9.2 3.4e-14 52.2 0.3 4.2 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.14649.1_2 - 1.5e-28 96.1 5.7 6e-09 35.0 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.4 MSTRG.14649.1_2 - 3e-25 86.4 6.9 4.7e-06 25.8 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.4 MSTRG.14649.1_2 - 4.8e-14 52.3 0.2 1.9e-08 34.3 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 MSTRG.14649.1_2 - 1.4e-08 34.5 0.8 0.00046 20.0 0.1 2.6 2 1 1 3 3 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 MSTRG.14649.1_2 - 1.8e-06 28.1 0.0 0.035 14.3 0.0 2.3 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.9 MSTRG.14649.1_2 - 0.00011 22.8 0.0 0.0092 16.7 0.0 2.2 1 1 1 2 2 2 1 EF-hand domain EFhand_Ca_insen PF08726.8 MSTRG.14649.1_2 - 0.00032 20.6 0.6 0.00074 19.4 0.1 1.8 2 0 0 2 2 2 1 Ca2+ insensitive EF hand UPF0154 PF03672.11 MSTRG.14649.1_2 - 0.00076 19.3 0.0 0.23 11.4 0.0 2.7 2 1 1 3 3 3 1 Uncharacterised protein family (UPF0154) DUF1103 PF06513.9 MSTRG.14649.1_2 - 0.008 15.7 0.9 0.011 15.2 0.9 1.1 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) DUF4497 PF14924.4 MSTRG.14649.1_2 - 0.013 15.8 0.0 6.6 7.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4497) DUF3349 PF11829.6 MSTRG.14649.1_2 - 0.068 13.8 0.3 9.2 7.0 0.0 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) Caleosin PF05042.11 MSTRG.14649.1_2 - 0.07 12.9 0.2 3.2 7.5 0.0 2.8 1 1 2 3 3 3 0 Caleosin related protein RNA_pol_Rpb4 PF03874.14 MSTRG.14649.1_2 - 0.1 12.8 0.5 8.5 6.6 0.1 2.3 2 0 0 2 2 2 0 RNA polymerase Rpb4 TerB PF05099.11 MSTRG.14649.1_2 - 0.11 12.3 0.3 4.5 7.1 0.0 2.2 1 1 1 2 2 2 0 Tellurite resistance protein TerB GPHH PF16905.3 MSTRG.14649.1_2 - 0.13 11.9 0.0 0.93 9.2 0.0 2.5 3 0 0 3 3 2 0 Voltage-dependent L-type calcium channel, IQ-associated SurA_N_2 PF13623.4 MSTRG.14649.1_2 - 0.26 11.0 0.7 3.3 7.4 0.1 2.2 1 1 1 2 2 2 0 SurA N-terminal domain Fer4 PF00037.25 MSTRG.15801.1_3 - 6.3e-14 51.0 17.5 2.3e-08 33.4 4.5 2.6 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.5 MSTRG.15801.1_3 - 9.4e-13 48.4 10.6 1.9e-12 47.4 10.6 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.4 MSTRG.15801.1_3 - 1.2e-10 42.1 6.2 5.3e-05 23.9 0.2 2.5 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.4 MSTRG.15801.1_3 - 1.8e-08 34.3 32.4 5.3e-06 26.3 12.3 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_9 PF13187.4 MSTRG.15801.1_3 - 2.8e-08 33.7 10.6 5.6e-08 32.7 10.6 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.4 MSTRG.15801.1_3 - 4.2e-08 33.0 21.3 3.4e-06 26.9 12.3 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.5 MSTRG.15801.1_3 - 4.8e-07 29.5 17.8 0.00053 19.8 5.4 2.6 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_8 PF13183.4 MSTRG.15801.1_3 - 9.3e-07 29.1 18.6 0.00016 21.9 11.0 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.5 MSTRG.15801.1_3 - 1.9e-06 27.5 12.1 0.0038 17.1 1.9 2.7 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.5 MSTRG.15801.1_3 - 7e-06 26.0 11.0 0.00037 20.6 1.8 2.8 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.4 MSTRG.15801.1_3 - 0.00038 20.8 11.7 0.045 14.1 12.8 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.8 MSTRG.15801.1_3 - 0.011 15.8 6.8 0.72 10.0 0.5 2.6 2 1 1 3 3 3 0 c-SKI Smad4 binding domain Fer4_13 PF13370.4 MSTRG.15801.1_3 - 0.027 14.9 14.9 0.89 10.0 2.8 2.6 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_18 PF13746.4 MSTRG.15801.1_3 - 0.073 13.1 8.7 1.5 8.9 1.5 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain ETF_QO PF05187.11 MSTRG.15801.1_3 - 0.39 10.7 5.5 1.3 9.0 0.5 2.2 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_22 PF17179.2 MSTRG.15801.1_3 - 1.2 9.9 12.0 3 8.6 1.8 2.5 1 1 1 2 2 2 0 4Fe-4S dicluster domain A_deaminase PF00962.20 MSTRG.22205.1_2 - 1.7e-20 73.5 0.0 2.7e-20 72.8 0.0 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase A_deaminase_N PF08451.9 MSTRG.22205.1_2 - 3.9e-13 49.4 0.1 9.3e-13 48.2 0.1 1.6 1 0 0 1 1 1 1 Adenosine/AMP deaminase N-terminal zf-CpG_bind_C PF12269.6 MSTRG.13089.1_2 - 3.8e-102 340.9 9.1 3.8e-102 340.9 9.1 2.2 2 0 0 2 2 2 1 CpG binding protein zinc finger C terminal domain zf-CXXC PF02008.18 MSTRG.13089.1_2 - 1.3e-15 56.9 19.8 1.3e-15 56.9 19.8 3.7 3 1 1 4 4 4 1 CXXC zinc finger domain PHD PF00628.27 MSTRG.13089.1_2 - 6.2e-10 38.7 12.5 6.2e-10 38.7 12.5 4.2 4 0 0 4 4 4 1 PHD-finger KIX PF02172.14 MSTRG.24116.7_2 - 2.7e-39 133.2 0.3 5.1e-39 132.3 0.3 1.5 1 0 0 1 1 1 1 KIX domain DUF902 PF06001.11 MSTRG.24116.7_2 - 1.2e-20 73.5 9.4 2.5e-20 72.5 9.4 1.6 1 0 0 1 1 1 1 Domain of Unknown Function (DUF902) Bromodomain PF00439.23 MSTRG.24116.7_2 - 3e-17 62.3 0.1 6.9e-17 61.2 0.1 1.6 1 0 0 1 1 1 1 Bromodomain KIX_2 PF16987.3 MSTRG.24116.7_2 - 0.00014 21.6 0.4 0.00042 20.1 0.1 2.0 2 0 0 2 2 2 1 KIX domain FPP PF05911.9 MSTRG.1010.6_1 - 0.00078 17.7 15.2 0.00078 17.7 15.2 2.1 1 1 1 2 2 2 1 Filament-like plant protein, long coiled-coil TSC22 PF01166.16 MSTRG.1010.6_1 - 0.071 13.3 0.2 0.071 13.3 0.2 4.4 4 1 0 4 4 4 0 TSC-22/dip/bun family PKcGMP_CC PF16808.3 MSTRG.1010.6_1 - 5 6.9 14.1 9.2 6.1 2.0 3.6 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4094 PF13334.4 MSTRG.1010.6_1 - 7.1 7.0 13.3 5 7.5 5.0 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) PRKG1_interact PF15898.3 MSTRG.1010.6_1 - 7.9 7.3 26.8 32 5.4 18.8 3.9 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain CheR_N PF03705.13 MSTRG.4464.1_2 - 0.071 12.7 0.4 0.12 11.9 0.4 1.4 1 0 0 1 1 1 0 CheR methyltransferase, all-alpha domain ATP-synt_S1 PF05827.10 MSTRG.4464.1_3 - 5.4e-54 181.9 0.0 7.8e-54 181.4 0.0 1.2 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) TFIIIC_delta PF12657.5 MSTRG.4464.1_3 - 0.046 13.5 0.0 0.11 12.3 0.0 1.6 1 1 0 1 1 1 0 Transcription factor IIIC subunit delta N-term Lipocalin_7 PF14651.4 MSTRG.6823.1_3 - 3.5e-31 107.7 1.8 4.6e-31 107.3 1.8 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin PF00061.21 MSTRG.6823.1_3 - 2.1e-17 63.5 2.4 2.9e-17 63.1 2.4 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Pox_RNA_pol PF03293.12 MSTRG.6823.1_3 - 0.094 12.3 0.2 0.14 11.8 0.2 1.3 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase, 18 kD subunit Pkinase PF00069.23 MSTRG.19221.2_1 - 1.5e-14 53.9 0.0 2.1e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.19221.2_1 - 0.0047 16.1 0.0 0.007 15.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase TnsD PF15978.3 MSTRG.19221.2_1 - 0.18 10.7 0.0 0.26 10.1 0.0 1.1 1 0 0 1 1 1 0 Tn7-like transposition protein D CRAL_TRIO PF00650.18 MSTRG.5810.1_2 - 5.3e-35 120.4 0.1 8.4e-35 119.7 0.1 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.4 MSTRG.5810.1_2 - 1.2e-07 31.8 0.0 2.4e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.13 MSTRG.5810.1_2 - 2.2e-07 30.8 0.5 5.2e-07 29.6 0.5 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain VPS13_mid_rpt PF16910.3 MSTRG.20521.3_3 - 1.1e-39 136.1 11.7 8.8e-33 113.6 0.0 7.5 7 3 0 7 7 7 4 Repeating coiled region of VPS13 UBA PF00627.29 MSTRG.20521.3_3 - 0.00011 21.9 0.0 0.00024 20.8 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain Lectin_C PF00059.19 MSTRG.25182.1_3 - 2.8e-19 69.7 0.0 4.3e-19 69.1 0.0 1.3 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.10 MSTRG.25182.1_3 - 0.037 13.5 0.1 0.061 12.8 0.1 1.3 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like TIMP PF00965.15 MSTRG.10965.2_1 - 4.6e-24 85.1 0.6 6.1e-24 84.7 0.6 1.2 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.19 MSTRG.10965.2_1 - 0.0025 17.4 0.0 0.005 16.5 0.0 1.5 1 1 0 1 1 1 1 UNC-6/NTR/C345C module Tr-sialidase_C PF11052.6 MSTRG.10965.2_1 - 0.0076 16.3 1.3 0.016 15.3 1.3 1.5 1 0 0 1 1 1 1 Trans-sialidase of Trypanosoma hydrophobic C-terminal TIMP PF00965.15 MSTRG.10965.2_3 - 5.1e-13 49.1 2.2 7.3e-13 48.6 2.2 1.2 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase FoP_duplication PF13865.4 MSTRG.3656.4_1 - 1.7e-20 73.2 16.2 4.5e-13 49.4 2.0 2.5 1 1 1 2 2 2 2 C-terminal duplication domain of Friend of PRMT1 LRR_8 PF13855.4 MSTRG.21569.2_1 - 3.8e-34 116.1 22.1 8.8e-09 34.9 2.1 5.3 5 0 0 5 5 5 5 Leucine rich repeat LRR_4 PF12799.5 MSTRG.21569.2_1 - 3.4e-28 97.0 23.2 1.7e-07 31.3 0.3 7.1 5 2 0 6 6 6 6 Leucine Rich repeats (2 copies) Ank_2 PF12796.5 MSTRG.21569.2_1 - 3.9e-10 40.1 0.4 1e-05 25.9 0.1 2.3 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) LRR_1 PF00560.31 MSTRG.21569.2_1 - 1.4e-08 33.9 24.7 5.5 7.7 0.0 10.3 10 1 0 10 10 10 2 Leucine Rich Repeat LRR_6 PF13516.4 MSTRG.21569.2_1 - 6.7e-06 25.6 19.0 3.9 7.6 0.3 7.9 8 0 0 8 8 8 1 Leucine Rich repeat LRR_9 PF14580.4 MSTRG.21569.2_1 - 0.0011 18.4 3.9 0.87 8.9 0.1 3.7 3 1 1 4 4 4 2 Leucine-rich repeat Ank_3 PF13606.4 MSTRG.21569.2_1 - 0.0033 17.7 0.4 20 6.0 0.0 4.2 4 0 0 4 4 4 0 Ankyrin repeat Ank_4 PF13637.4 MSTRG.21569.2_1 - 0.0033 17.8 0.4 1.1 9.7 0.0 3.3 3 1 0 3 3 3 1 Ankyrin repeats (many copies) AAA_16 PF13191.4 MSTRG.21569.2_1 - 0.014 15.6 0.1 0.036 14.3 0.1 1.7 1 0 0 1 1 1 0 AAA ATPase domain Ank_5 PF13857.4 MSTRG.21569.2_1 - 0.045 14.0 1.8 12 6.2 0.1 3.5 2 1 1 3 3 3 0 Ankyrin repeats (many copies) COR PF16095.3 MSTRG.21569.2_3 - 2.8e-20 72.9 0.0 4.3e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Roc PF08477.11 MSTRG.21569.2_3 - 2.4e-05 24.4 0.0 0.0001 22.4 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Pkinase_Tyr PF07714.15 MSTRG.21569.2_3 - 0.00022 20.4 0.0 0.0004 19.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.21569.2_3 - 0.044 13.0 0.0 0.26 10.4 0.0 1.9 1 1 0 1 1 1 0 Protein kinase domain eIF-1a PF01176.17 MSTRG.1106.4_2 - 1.2e-20 72.9 0.1 2e-20 72.2 0.1 1.4 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 CRAL_TRIO PF00650.18 MSTRG.7207.1_1 - 1.3e-42 145.1 0.0 1.8e-42 144.6 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain GOLD_2 PF13897.4 MSTRG.7207.1_1 - 2.3e-08 34.5 0.1 0.00022 21.6 0.0 2.4 1 1 1 2 2 2 2 Golgi-dynamics membrane-trafficking CRAL_TRIO_N PF03765.13 MSTRG.7207.1_1 - 2.1e-05 24.5 0.7 5.1e-05 23.2 0.7 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.4 MSTRG.7207.1_1 - 0.0054 16.7 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain DUF4507 PF14964.4 MSTRG.12086.5_1 - 5.2e-31 107.7 1.3 5.7e-31 107.6 1.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4507) Nckap1 PF09735.7 MSTRG.26349.1_3 - 0 1429.9 21.1 0 1429.8 21.1 1.0 1 0 0 1 1 1 1 Membrane-associated apoptosis protein IF-2 PF11987.6 MSTRG.19286.1_3 - 1.2e-24 86.3 0.1 1.9e-24 85.7 0.1 1.3 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.4 MSTRG.19286.1_3 - 0.0074 16.1 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu domain 4 PHD PF00628.27 MSTRG.23026.1_3 - 6.3e-47 157.1 105.9 2.8e-10 39.8 8.1 8.7 6 3 2 8 8 8 7 PHD-finger zf-HC5HC2H PF13771.4 MSTRG.23026.1_3 - 2.4e-12 46.8 4.0 2.4e-12 46.8 4.0 7.8 3 2 2 7 7 7 2 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.4 MSTRG.23026.1_3 - 8.8e-11 41.8 4.6 8.8e-11 41.8 4.6 7.6 3 2 4 7 7 7 2 PHD-zinc-finger like domain PHD_2 PF13831.4 MSTRG.23026.1_3 - 0.0012 18.2 65.2 0.0035 16.7 0.9 7.9 6 1 0 6 6 6 4 PHD-finger Ribosomal_L5e PF17144.2 MSTRG.12162.1_2 - 7.9e-89 295.7 0.2 7.9e-89 295.7 0.2 2.0 2 0 0 2 2 2 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.4 MSTRG.12162.1_2 - 6.4e-36 123.0 4.3 6.4e-36 123.0 4.3 1.7 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Proteasom_PSMB PF10508.7 MSTRG.12013.1_3 - 1e-174 581.6 1.0 1.2e-174 581.4 1.0 1.0 1 0 0 1 1 1 1 Proteasome non-ATPase 26S subunit RICTOR_V PF14668.4 MSTRG.12013.1_3 - 4.8e-05 23.4 0.2 1.4 9.1 0.0 4.3 2 1 3 5 5 5 3 Rapamycin-insensitive companion of mTOR, domain 5 HEAT_2 PF13646.4 MSTRG.12013.1_3 - 5.2e-05 23.4 0.0 0.024 14.9 0.0 3.5 2 1 1 3 3 3 1 HEAT repeats V-ATPase_H_C PF11698.6 MSTRG.12013.1_3 - 0.0028 17.6 4.5 0.16 12.0 0.6 3.7 3 1 0 3 3 3 1 V-ATPase subunit H TIP120 PF08623.8 MSTRG.12013.1_3 - 0.0029 17.3 2.1 3 7.5 0.0 3.2 3 0 0 3 3 3 1 TATA-binding protein interacting (TIP20) RICTOR_M PF14666.4 MSTRG.12013.1_3 - 0.056 13.1 2.8 28 4.4 0.0 4.3 4 1 1 5 5 5 0 Rapamycin-insensitive companion of mTOR, middle domain Cnd1 PF12717.5 MSTRG.12013.1_3 - 0.08 12.8 7.0 1.3 8.8 1.3 3.4 2 1 2 4 4 4 0 non-SMC mitotic condensation complex subunit 1 STAG PF08514.9 MSTRG.12013.1_3 - 0.09 12.6 0.3 4.9 7.0 0.0 2.8 2 0 0 2 2 2 0 STAG domain MFS_1 PF07690.14 MSTRG.7878.2_1 - 3.2e-56 190.6 47.1 7.6e-53 179.5 31.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DSPc PF00782.18 MSTRG.10272.2_3 - 9.4e-33 112.7 0.1 1.6e-32 111.9 0.1 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DEK_C PF08766.9 MSTRG.10272.2_3 - 7.6e-10 38.4 0.6 1.6e-09 37.4 0.6 1.4 1 0 0 1 1 1 1 DEK C terminal domain Y_phosphatase PF00102.25 MSTRG.10272.2_3 - 0.031 13.7 0.0 0.055 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase BUD22 PF09073.8 MSTRG.10272.2_3 - 0.034 13.4 7.2 0.059 12.6 7.2 1.3 1 0 0 1 1 1 0 BUD22 PTPlike_phytase PF14566.4 MSTRG.10272.2_3 - 0.15 12.0 1.0 0.22 11.5 0.0 1.9 2 0 0 2 2 2 0 Inositol hexakisphosphate Nop14 PF04147.10 MSTRG.10272.2_3 - 0.28 9.2 12.5 0.44 8.6 12.5 1.2 1 0 0 1 1 1 0 Nop14-like family Astro_capsid_p PF12226.6 MSTRG.10272.2_3 - 0.32 10.0 5.6 0.65 9.0 5.6 1.4 1 0 0 1 1 1 0 Turkey astrovirus capsid protein RXT2_N PF08595.9 MSTRG.10272.2_3 - 0.71 9.8 7.2 2 8.3 7.2 1.8 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF4746 PF15928.3 MSTRG.10272.2_3 - 2.1 7.6 5.6 3.9 6.7 5.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF1510 PF07423.9 MSTRG.10272.2_3 - 8.6 5.6 14.4 17 4.6 14.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) FAM117 PF15388.4 MSTRG.12620.4_1 - 3.1e-95 318.9 8.2 3.1e-95 318.9 8.2 1.9 2 0 0 2 2 2 1 Protein Family FAM117 Lung_7-TM_R PF06814.11 MSTRG.8843.2_2 - 1.7e-12 47.0 0.4 3e-12 46.2 0.4 1.3 1 0 0 1 1 1 1 Lung seven transmembrane receptor Fez1 PF06818.13 MSTRG.7345.1_1 - 1.4e-46 159.4 44.1 3.1e-23 83.1 9.5 3.4 2 1 1 3 3 3 3 Fez1 Atg14 PF10186.7 MSTRG.7345.1_1 - 2.6 6.9 28.8 0.032 13.2 13.9 2.9 2 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 zf-CpG_bind_C PF12269.6 MSTRG.13089.2_2 - 3.8e-102 340.9 9.1 3.8e-102 340.9 9.1 2.2 2 0 0 2 2 2 1 CpG binding protein zinc finger C terminal domain zf-CXXC PF02008.18 MSTRG.13089.2_2 - 1.3e-15 57.0 19.8 1.3e-15 57.0 19.8 3.6 3 1 1 4 4 4 1 CXXC zinc finger domain PHD PF00628.27 MSTRG.13089.2_2 - 6.1e-10 38.7 12.5 6.1e-10 38.7 12.5 4.1 4 0 0 4 4 4 1 PHD-finger PHD_2 PF13831.4 MSTRG.13089.2_2 - 0.17 11.3 10.8 0.072 12.5 5.4 3.0 2 0 0 2 2 2 0 PHD-finger PXA PF02194.13 MSTRG.16397.6_1 - 4.4e-32 111.1 0.1 6.5e-32 110.5 0.1 1.3 1 0 0 1 1 1 1 PXA domain RGS PF00615.17 MSTRG.16397.6_1 - 7.9e-12 45.4 0.0 1.2e-11 44.7 0.0 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain PX PF00787.22 MSTRG.16397.6_2 - 2.2e-18 66.2 0.4 4.8e-18 65.1 0.4 1.6 1 0 0 1 1 1 1 PX domain Nexin_C PF08628.10 MSTRG.16397.6_3 - 3.1e-16 59.8 0.0 5.8e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 Sorting nexin C terminal APC_u13 PF16634.3 MSTRG.16397.6_3 - 0.08 12.7 0.1 0.18 11.6 0.1 1.5 1 0 0 1 1 1 0 Unstructured region on APC between APC_crr and SAMP PCNP PF15473.4 MSTRG.17505.2_2 - 2.3e-60 203.7 6.6 2.9e-60 203.4 6.6 1.1 1 0 0 1 1 1 1 PEST, proteolytic signal-containing nuclear protein family UBX PF00789.18 MSTRG.23552.1_3 - 6.1e-19 67.9 0.1 1.3e-18 66.9 0.1 1.6 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.4 MSTRG.23552.1_3 - 4.3e-07 29.5 1.0 8.2e-07 28.6 1.0 1.4 1 0 0 1 1 1 1 UBA-like domain ubiquitin PF00240.21 MSTRG.23552.1_3 - 4.4e-06 26.2 0.2 0.096 12.3 0.1 2.7 2 0 0 2 2 2 2 Ubiquitin family Ubiquitin_2 PF14560.4 MSTRG.23552.1_3 - 0.0025 18.1 0.0 0.21 11.9 0.0 2.5 2 0 0 2 2 2 1 Ubiquitin-like domain AAA_11 PF13086.4 MSTRG.23552.1_3 - 0.07 12.7 2.6 0.13 11.8 2.6 1.3 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.4 MSTRG.23552.1_3 - 2.4 8.5 5.6 3.9 7.8 5.6 1.2 1 0 0 1 1 1 0 AAA domain Borrelia_P83 PF05262.9 MSTRG.23552.1_3 - 2.8 6.2 7.9 4 5.7 7.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein TB2_DP1_HVA22 PF03134.17 MSTRG.21114.1_1 - 8.8e-27 92.7 9.7 1.5e-26 92.0 9.7 1.4 1 0 0 1 1 1 1 TB2/DP1, HVA22 family DUF4535 PF15054.4 MSTRG.10293.1_1 - 1.4e-10 40.6 0.3 2.5e-10 39.8 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4535) Nuc_sug_transp PF04142.13 MSTRG.10293.1_2 - 4.2e-42 144.3 13.2 6.3e-42 143.7 13.2 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.18 MSTRG.10293.1_2 - 0.015 15.3 31.7 0.015 15.3 7.9 2.3 2 0 0 2 2 2 0 EamA-like transporter family CAMSAP_CH PF11971.6 MSTRG.5614.1_3 - 5.7e-25 86.8 0.6 1.4e-24 85.6 0.2 1.8 2 0 0 2 2 2 1 CAMSAP CH domain CH PF00307.29 MSTRG.5614.1_3 - 6.6e-22 77.6 0.6 1.2e-21 76.8 0.6 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain CDC24 PF06395.9 MSTRG.5614.1_3 - 3.8e-06 27.0 0.2 6.9e-06 26.1 0.2 1.4 1 0 0 1 1 1 1 CDC24 Calponin SMP_2 PF10144.7 MSTRG.5614.1_3 - 0.04 13.4 0.1 0.089 12.3 0.0 1.5 2 0 0 2 2 2 0 Bacterial virulence factor haemolysin Csm1 PF12539.6 MSTRG.5614.1_3 - 0.066 13.7 0.1 11 6.6 0.2 2.3 2 0 0 2 2 2 0 Chromosome segregation protein Csm1/Pcs1 Metallophos_2 PF12850.5 MSTRG.1261.6_3 - 1.5e-28 100.0 0.0 1.1e-20 74.4 0.0 2.1 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.26 MSTRG.1261.6_3 - 3.4e-05 24.3 1.9 0.45 10.8 0.1 3.2 2 1 1 3 3 3 2 Calcineurin-like phosphoesterase PAP_assoc PF03828.17 MSTRG.13356.1_1 - 9.2e-17 60.9 0.0 1.8e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.21 MSTRG.13356.1_1 - 3.5e-14 52.7 0.0 6e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyltransferase domain ACBP PF00887.17 MSTRG.13356.1_1 - 0.18 11.9 0.0 0.34 11.0 0.0 1.4 1 0 0 1 1 1 0 Acyl CoA binding protein Dysbindin PF04440.14 MSTRG.13356.1_1 - 0.8 9.7 7.3 3.9 7.5 7.7 1.8 2 0 0 2 2 2 0 Dysbindin (Dystrobrevin binding protein 1) Nup84_Nup100 PF04121.11 MSTRG.24293.1_2 - 6.1e-200 665.8 14.5 7.1e-200 665.6 14.5 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 Fe_bilin_red PF05996.10 MSTRG.24293.1_2 - 0.081 12.4 0.3 14 5.1 0.0 2.6 2 0 0 2 2 2 0 Ferredoxin-dependent bilin reductase Nepo_coat_N PF03689.13 MSTRG.12375.3_1 - 0.086 12.7 0.4 0.27 11.1 0.0 1.9 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain Zona_pellucida PF00100.21 MSTRG.12375.3_3 - 3.9e-18 66.0 1.0 5.3e-18 65.6 1.0 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain DAZAP2 PF11029.6 MSTRG.24228.1_2 - 0.018 15.9 0.6 0.018 15.9 0.6 1.9 2 0 0 2 2 2 0 DAZ associated protein 2 (DAZAP2) ERAP1_C PF11838.6 MSTRG.24228.1_3 - 1.7e-73 247.9 0.0 2.2e-73 247.4 0.0 1.1 1 0 0 1 1 1 1 ERAP1-like C-terminal domain FDX-ACB PF03147.12 MSTRG.9486.1_1 - 1.8e-12 47.4 0.0 2.7e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain PH PF00169.27 MSTRG.643.2_1 - 9.9e-07 29.1 0.1 1.5e-06 28.5 0.1 1.3 1 0 0 1 1 1 1 PH domain PH_10 PF15411.4 MSTRG.643.2_1 - 0.0002 21.5 1.7 0.00064 19.9 1.7 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain Asparaginase_2 PF01112.16 MSTRG.7772.1_2 - 1.3e-57 195.1 2.0 1.8e-57 194.6 2.0 1.2 1 0 0 1 1 1 1 Asparaginase Prefoldin PF02996.15 MSTRG.7772.1_2 - 0.031 14.1 0.0 0.075 12.8 0.0 1.6 1 0 0 1 1 1 0 Prefoldin subunit Yip1 PF04893.15 MSTRG.26263.1_1 - 9.6e-07 28.5 17.1 1.6e-06 27.8 17.1 1.3 1 0 0 1 1 1 1 Yip1 domain YIF1 PF03878.13 MSTRG.26263.1_1 - 0.019 14.4 7.0 0.84 9.0 7.0 2.2 1 1 0 1 1 1 0 YIF1 Romo1 PF10247.7 MSTRG.26263.1_1 - 0.14 12.4 0.6 0.35 11.1 0.6 1.6 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 FAM222A PF15258.4 MSTRG.602.1_2 - 8.1e-60 203.3 18.6 6.5e-58 197.0 19.1 2.6 1 1 1 2 2 2 2 Protein family of FAM222A zf-C2H2 PF00096.24 MSTRG.9136.1_2 - 4.3e-31 105.5 170.6 0.00056 20.1 1.0 19.4 19 0 0 19 19 19 16 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.9136.1_2 - 8.4e-31 104.9 130.8 1.1e-07 31.8 1.1 19.3 19 0 0 19 19 19 13 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.9136.1_2 - 2.4e-28 96.2 158.8 0.00099 19.6 1.8 19.5 19 0 0 19 19 19 16 C2H2-type zinc finger zf-H2C2_5 PF13909.4 MSTRG.9136.1_2 - 4.5e-28 96.5 99.8 2.4e-09 36.7 0.2 13.2 14 1 0 14 14 14 7 C2H2-type zinc-finger domain zf-Di19 PF05605.10 MSTRG.9136.1_2 - 9.9e-05 22.4 12.5 0.00052 20.1 1.2 11.8 10 1 1 12 12 12 5 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.5 MSTRG.9136.1_2 - 0.0018 18.4 7.3 0.0063 16.7 1.7 13.0 14 0 0 14 14 14 3 Zinc-finger of C2H2 type zf-C4_ClpX PF06689.11 MSTRG.9136.1_2 - 0.0098 15.6 0.3 0.0098 15.6 0.3 4.8 4 0 0 4 4 4 1 ClpX C4-type zinc finger 60KD_IMP PF02096.18 MSTRG.25795.2_1 - 5.9e-09 35.9 0.2 5.9e-09 35.9 0.2 1.5 2 0 0 2 2 2 1 60Kd inner membrane protein OST-HTH PF12872.5 MSTRG.19017.1_1 - 1.8e-66 219.8 5.4 4.1e-12 45.7 0.0 7.8 7 0 0 7 7 7 7 OST-HTH/LOTUS domain Limkain-b1 PF11608.6 MSTRG.19017.1_1 - 1.7e-35 120.8 0.0 3.3e-35 119.9 0.0 1.5 1 0 0 1 1 1 1 Limkain b1 NYN PF01936.16 MSTRG.19017.1_1 - 2.1e-20 73.6 0.0 4.7e-20 72.4 0.0 1.6 1 0 0 1 1 1 1 NYN domain RRM_1 PF00076.20 MSTRG.19017.1_1 - 1.1e-05 25.0 0.0 0.024 14.3 0.0 2.9 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 MSTRG.19017.1_1 - 0.003 17.0 0.0 0.24 10.9 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3990 PF13151.4 MSTRG.14511.3_1 - 0.092 12.3 0.1 0.15 11.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3990) Arm PF00514.21 MSTRG.2677.1_3 - 4.3e-26 90.0 7.9 2.3e-06 27.3 0.0 6.7 6 0 0 6 6 6 4 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.7 MSTRG.2677.1_3 - 3.1e-07 30.2 0.9 0.0015 18.5 0.1 3.1 3 0 0 3 3 3 2 Spinocerebellar ataxia type 10 protein domain DUF383 PF04063.12 MSTRG.2677.1_3 - 9.1e-05 22.1 4.3 0.93 9.0 0.1 3.7 2 2 1 3 3 3 3 Domain of unknown function (DUF383) HEAT_EZ PF13513.4 MSTRG.2677.1_3 - 0.00014 22.1 0.5 1.4 9.3 0.1 4.3 4 0 0 4 4 4 1 HEAT-like repeat Nipped-B_C PF12830.5 MSTRG.2677.1_3 - 0.00085 19.2 0.0 0.0025 17.6 0.0 1.8 1 0 0 1 1 1 1 Sister chromatid cohesion C-terminus Arm_2 PF04826.11 MSTRG.2677.1_3 - 0.027 13.8 1.4 0.63 9.3 0.2 2.4 2 0 0 2 2 2 0 Armadillo-like HEAT PF02985.20 MSTRG.2677.1_3 - 0.03 14.4 0.1 0.44 10.8 0.0 2.7 2 0 0 2 2 2 0 HEAT repeat DERM PF14704.4 MSTRG.23944.1_2 - 7.9e-24 84.7 1.0 9.3e-24 84.5 1.0 1.1 1 0 0 1 1 1 1 Dermatopontin RNA_pol_Rpb4 PF03874.14 MSTRG.24089.1_2 - 0.13 12.5 0.6 0.22 11.8 0.6 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb4 Neur_chan_memb PF02932.14 MSTRG.19229.1_1 - 1e-75 254.8 0.3 1.4e-75 254.3 0.3 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 MSTRG.19229.1_1 - 9.2e-67 224.5 7.1 1.3e-66 224.0 7.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain LIM PF00412.20 MSTRG.26871.2_3 - 2.2e-29 101.3 13.7 1.8e-15 56.8 1.5 2.6 2 0 0 2 2 2 2 LIM domain Sedlin_N PF04628.11 MSTRG.22989.1_3 - 9.7e-48 161.5 0.2 1.5e-47 160.9 0.2 1.3 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.10 MSTRG.22989.1_3 - 1.3e-08 34.7 0.1 2.2e-08 34.0 0.1 1.2 1 0 0 1 1 1 1 Sybindin-like family MFS_1 PF07690.14 MSTRG.27238.1_3 - 3.2e-12 45.9 20.4 3.2e-12 45.9 20.4 2.9 2 1 1 3 3 3 2 Major Facilitator Superfamily Ion_trans PF00520.29 MSTRG.4414.1_1 - 8.8e-20 70.8 0.8 1.2e-19 70.4 0.8 1.1 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.10 MSTRG.4414.1_1 - 0.0041 15.7 0.2 0.0053 15.4 0.2 1.1 1 0 0 1 1 1 1 Polycystin cation channel tRNA-synt_1 PF00133.20 MSTRG.9125.1_1 - 5.3e-49 166.8 0.0 3.1e-26 91.7 0.4 5.7 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.9 MSTRG.9125.1_1 - 2.8e-28 98.7 0.0 5.2e-18 64.9 0.0 3.2 3 0 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.4 MSTRG.9125.1_1 - 9e-11 41.5 0.0 4.4e-09 36.0 0.0 2.2 1 1 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 Anticodon_1 PF08264.11 MSTRG.9125.1_1 - 1.5e-10 41.1 0.0 2.7e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.17 MSTRG.9125.1_1 - 1.3e-05 24.6 0.0 0.13 11.5 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.16 MSTRG.9125.1_1 - 0.072 11.9 0.0 1.3 7.7 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (K) LRRNT PF01462.16 MSTRG.9125.1_2 - 0.19 11.3 4.5 0.23 11.1 0.0 3.4 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain CCDC84 PF14968.4 MSTRG.16875.1_1 - 4.2e-52 177.7 10.4 5.9e-52 177.2 10.4 1.2 1 0 0 1 1 1 1 Coiled coil protein 84 CCDC84 PF14968.4 MSTRG.16875.1_2 - 1e-38 133.7 7.4 1.4e-38 133.3 7.4 1.1 1 0 0 1 1 1 1 Coiled coil protein 84 zf-RING_9 PF13901.4 MSTRG.23148.1_2 - 2.9e-67 226.5 13.4 2.9e-67 226.5 13.4 2.9 4 0 0 4 4 4 2 Putative zinc-RING and/or ribbon C1_1 PF00130.20 MSTRG.23148.1_2 - 1.4e-06 27.9 10.5 1.4e-06 27.9 10.5 5.4 6 1 0 6 6 6 3 Phorbol esters/diacylglycerol binding domain (C1 domain) CaMKII_AD PF08332.8 MSTRG.386.3_2 - 2.6e-59 198.8 0.0 3.7e-59 198.3 0.0 1.2 1 0 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II association domain SnoaL_3 PF13474.4 MSTRG.386.3_2 - 7.3e-10 39.0 0.0 1.1e-09 38.5 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.4 MSTRG.386.3_2 - 1e-08 35.4 0.0 1.6e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_2 PF12680.5 MSTRG.386.3_2 - 0.18 12.3 0.0 0.29 11.7 0.0 1.3 1 0 0 1 1 1 0 SnoaL-like domain PLDc_3 PF13918.4 MSTRG.7447.2_1 - 7.9e-32 110.2 0.0 1.2e-31 109.6 0.0 1.3 1 0 0 1 1 1 1 PLD-like domain PLDc_2 PF13091.4 MSTRG.7447.2_1 - 1e-19 70.6 0.0 8.3e-11 41.8 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.20 MSTRG.7447.2_1 - 4.5e-11 42.3 1.9 1.3e-06 28.2 0.3 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif SEA PF01390.18 MSTRG.2477.1_2 - 2.9e-13 49.9 0.0 8.1e-13 48.4 0.0 1.8 1 0 0 1 1 1 1 SEA domain EB PF01683.16 MSTRG.2477.1_2 - 0.017 15.3 6.1 0.017 15.3 6.1 3.5 3 0 0 3 3 3 0 EB module Orthoreo_P10 PF07204.9 MSTRG.2477.1_2 - 0.52 10.2 6.8 1.7 8.5 6.8 1.9 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 EGF_MSP1_1 PF12946.5 MSTRG.2477.1_2 - 4.7 7.2 11.0 11 6.1 3.6 2.6 2 0 0 2 2 2 0 MSP1 EGF domain 1 DUF4097 PF13349.4 MSTRG.27078.11_3 - 3.2e-11 42.9 0.0 1.6 7.9 0.0 8.4 4 1 2 6 6 6 5 Putative adhesin PDZ PF00595.22 MSTRG.27078.11_3 - 0.00032 20.9 0.0 0.00091 19.4 0.0 1.8 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Bactofilin PF04519.11 MSTRG.27078.11_3 - 6.1 7.1 5.8 33 4.7 0.0 5.2 5 0 0 5 5 5 0 Polymer-forming cytoskeletal 7TM_GPCR_Srsx PF10320.7 MSTRG.20172.1_2 - 0.052 12.8 0.0 0.063 12.5 0.0 1.0 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx SNF PF00209.16 MSTRG.24762.1_1 - 3.2e-229 761.8 42.0 3.7e-229 761.6 42.0 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Glyco_transf_7N PF13733.4 MSTRG.6574.1_1 - 2.7e-53 179.1 0.0 4.1e-53 178.5 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.12 MSTRG.6574.1_1 - 6.1e-26 89.7 0.7 1.2e-25 88.8 0.7 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase DnaB_2 PF07261.9 MSTRG.10114.1_1 - 0.11 12.2 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Replication initiation and membrane attachment BALF1 PF06861.9 MSTRG.10114.1_3 - 0.032 13.7 0.0 0.04 13.4 0.0 1.0 1 0 0 1 1 1 0 BALF1 protein DAG_kinase_N PF14513.4 MSTRG.11603.1_3 - 2.5e-20 73.2 0.4 3.2e-20 72.9 0.4 1.1 1 0 0 1 1 1 1 Diacylglycerol kinase N-terminus DM PF00751.16 MSTRG.22266.2_2 - 2.1e-19 69.0 14.9 5.1e-19 67.8 14.9 1.7 1 0 0 1 1 1 1 DM DNA binding domain Auts2 PF15336.4 MSTRG.18163.2_1 - 7.2e-84 281.2 3.2 7.2e-84 281.2 3.2 6.9 5 2 2 8 8 8 1 Autism susceptibility gene 2 protein REV PF00424.16 MSTRG.18163.2_1 - 0.58 10.1 8.3 0.075 12.9 3.3 2.2 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) PSP PF04046.14 MSTRG.16862.2_2 - 1.9e-15 56.3 0.7 4e-15 55.3 0.7 1.6 1 0 0 1 1 1 1 PSP zf-CCHC PF00098.21 MSTRG.16862.2_2 - 0.0014 18.5 1.9 0.0037 17.1 1.9 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.4 MSTRG.16862.2_2 - 0.05 13.2 0.1 0.11 12.0 0.1 1.6 1 0 0 1 1 1 0 Zinc knuckle MotB_plug PF13677.4 MSTRG.3017.1_3 - 0.11 12.0 0.7 0.19 11.2 0.7 1.4 1 0 0 1 1 1 0 Membrane MotB of proton-channel complex MotA/MotB CH PF00307.29 MSTRG.19854.4_1 - 2.6e-52 175.5 1.6 9.9e-28 96.4 0.1 2.9 3 0 0 3 3 3 2 Calponin homology (CH) domain Spectrin PF00435.19 MSTRG.19854.4_1 - 1.4e-42 144.3 18.5 2.2e-18 66.5 2.6 4.3 4 1 1 5 5 5 3 Spectrin repeat CAMSAP_CH PF11971.6 MSTRG.19854.4_1 - 1.1e-09 37.9 0.1 2.2e-07 30.5 0.0 2.7 2 0 0 2 2 2 2 CAMSAP CH domain CH_2 PF06294.9 MSTRG.19854.4_1 - 0.0014 18.6 0.3 0.53 10.3 0.0 3.8 3 0 0 3 3 3 1 CH-like domain in sperm protein Choline_transpo PF04515.10 MSTRG.11567.3_2 - 1.8e-101 339.5 36.7 1.8e-101 339.5 36.7 2.9 2 1 1 3 3 3 1 Plasma-membrane choline transporter TACC PF05010.12 MSTRG.7754.2_2 - 5.7e-82 274.2 32.8 5.7e-82 274.2 32.8 2.6 2 0 0 2 2 2 1 Transforming acidic coiled-coil-containing protein (TACC) Rap_GAP PF02145.13 MSTRG.3262.5_2 - 8.2e-05 22.1 0.0 0.061 12.8 0.0 3.2 4 0 0 4 4 4 2 Rap/ran-GAP RRM_1 PF00076.20 MSTRG.15724.1_3 - 6.6e-30 102.6 0.0 7.5e-17 60.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 MSTRG.15724.1_3 - 0.0011 18.5 0.0 0.23 11.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.15724.1_3 - 0.059 13.4 0.0 0.38 10.8 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif Cas_Cas2CT1978 PF09707.8 MSTRG.15724.1_3 - 0.12 12.3 0.0 1.1 9.3 0.0 2.4 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) Gpi16 PF04113.12 MSTRG.4731.1_2 - 0.017 13.4 0.0 0.022 13.1 0.0 1.0 1 0 0 1 1 1 0 Gpi16 subunit, GPI transamidase component WD40 PF00400.30 MSTRG.11834.2_2 - 4.6e-05 24.0 0.0 3.5 8.5 0.0 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.11834.2_2 - 0.028 14.6 0.0 1.7 8.9 0.0 2.8 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain S6OS1 PF15676.3 MSTRG.14900.1_3 - 0.0014 17.1 26.5 0.084 11.2 20.1 2.3 2 0 0 2 2 2 2 Six6 opposite strand transcript 1 family Sec3_C PF09763.7 MSTRG.23862.3_1 - 3.7e-190 633.7 13.3 5.2e-190 633.2 13.3 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.4 MSTRG.23862.3_1 - 1.7e-27 95.2 2.6 4.9e-27 93.8 2.6 1.8 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH FlaC_arch PF05377.9 MSTRG.23862.3_1 - 0.013 15.8 3.1 0.16 12.3 0.9 3.2 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF310 PF03750.11 MSTRG.23862.3_1 - 0.27 11.9 3.4 0.49 11.1 0.7 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF310) TPR_MLP1_2 PF07926.10 MSTRG.23862.3_1 - 0.43 10.5 7.0 1.1 9.2 7.0 1.7 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein GlnD_UR_UTase PF08335.9 MSTRG.23862.3_1 - 0.73 9.8 4.1 0.62 10.0 0.3 2.7 3 0 0 3 3 3 0 GlnD PII-uridylyltransferase FlgN PF05130.10 MSTRG.23862.3_1 - 1.2 9.6 9.8 1.5 9.1 6.0 2.9 3 0 0 3 3 3 0 FlgN protein USP8_interact PF08941.8 MSTRG.507.1_3 - 3.9e-86 287.3 1.9 5.5e-86 286.8 1.9 1.2 1 0 0 1 1 1 1 USP8 interacting zf-C3HC4_2 PF13923.4 MSTRG.507.1_3 - 9.2e-09 34.9 7.4 9.2e-09 34.9 7.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 MSTRG.507.1_3 - 9.8e-08 31.6 7.1 3.8e-07 29.7 7.1 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.507.1_3 - 4.1e-07 30.0 6.8 1.4e-06 28.3 6.8 2.0 1 0 0 1 1 1 1 Ring finger domain Sina PF03145.14 MSTRG.507.1_3 - 4.7e-07 29.9 2.3 8.9e-07 29.0 2.3 1.4 1 0 0 1 1 1 1 Seven in absentia protein family zf-rbx1 PF12678.5 MSTRG.507.1_3 - 1.1e-06 28.7 4.6 3.8e-06 27.0 4.6 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_6 PF14835.4 MSTRG.507.1_3 - 1.1e-06 28.2 1.5 8.5e-06 25.4 0.7 2.6 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.4 MSTRG.507.1_3 - 7.8e-06 25.8 7.2 3.1e-05 23.9 7.2 2.1 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 MSTRG.507.1_3 - 2.8e-05 23.8 3.1 7.4e-05 22.4 3.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.6 MSTRG.507.1_3 - 7.3e-05 22.4 3.1 0.00021 20.9 1.7 2.2 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.4 MSTRG.507.1_3 - 7.4e-05 22.6 8.0 0.00021 21.1 8.0 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.4 MSTRG.507.1_3 - 7.7e-05 22.4 5.2 0.00025 20.8 5.2 2.0 1 0 0 1 1 1 1 zinc-RING finger domain U-box PF04564.13 MSTRG.507.1_3 - 0.0022 18.0 0.0 0.0052 16.8 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-TRAF PF02176.16 MSTRG.507.1_3 - 0.0046 17.5 3.0 0.67 10.6 1.8 2.6 1 1 1 2 2 2 1 TRAF-type zinc finger zf-ANAPC11 PF12861.5 MSTRG.507.1_3 - 0.0053 16.7 2.0 0.015 15.2 2.0 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger SlyX PF04102.10 MSTRG.507.1_3 - 0.013 16.0 2.0 0.03 14.8 2.0 1.6 1 0 0 1 1 1 0 SlyX DUF641 PF04859.10 MSTRG.507.1_3 - 0.016 15.4 0.6 0.028 14.6 0.6 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Trimer_CC PF08954.9 MSTRG.507.1_3 - 0.024 14.1 0.2 0.075 12.5 0.2 1.8 1 0 0 1 1 1 0 Trimerisation motif zf-TRAF_2 PF15965.3 MSTRG.507.1_3 - 0.048 14.0 9.4 0.093 13.1 6.8 2.7 2 1 1 3 3 2 0 TRAF-like zinc-finger Laminin_II PF06009.10 MSTRG.507.1_3 - 0.085 12.7 0.8 0.15 11.9 0.8 1.3 1 0 0 1 1 1 0 Laminin Domain II TMF_DNA_bd PF12329.6 MSTRG.507.1_3 - 0.13 12.2 0.5 0.24 11.3 0.5 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding BLOC1_2 PF10046.7 MSTRG.507.1_3 - 0.44 10.8 2.1 0.85 9.8 2.1 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Prok-RING_4 PF14447.4 MSTRG.507.1_3 - 0.89 9.3 7.4 6.7 6.5 7.8 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.3 MSTRG.507.1_3 - 0.9 9.6 9.4 0.052 13.6 3.8 1.9 2 0 0 2 2 1 0 zinc RING finger of MSL2 Zn_ribbon_17 PF17120.3 MSTRG.507.1_3 - 1.7 8.2 10.0 0.57 9.7 4.4 2.4 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type DUF4700 PF15771.3 MSTRG.28019.1_1 - 1.3e-22 80.2 26.3 3.4e-22 78.8 26.2 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4700) DUF1664 PF07889.10 MSTRG.28019.1_1 - 0.071 13.0 6.7 0.034 14.0 2.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF1054 PF06335.10 MSTRG.28019.1_1 - 0.62 9.8 4.1 0.33 10.7 1.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1054) DUF745 PF05335.11 MSTRG.28019.1_1 - 0.79 9.3 7.3 1 8.9 5.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF745) DUF342 PF03961.11 MSTRG.28019.1_1 - 1.2 7.6 7.1 1.6 7.1 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) NPV_P10 PF05531.10 MSTRG.28019.1_1 - 1.8 8.9 7.3 8.5 6.8 6.3 2.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Glyco_hydro_15 PF00723.19 MSTRG.11262.5_1 - 7.3e-91 305.1 0.0 9.3e-91 304.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 DDE_Tnp_1_7 PF13843.4 MSTRG.1463.3_3 - 3.3e-75 253.4 0.2 4.5e-75 253.0 0.2 1.2 1 0 0 1 1 1 1 Transposase IS4 Chromo PF00385.22 MSTRG.1463.3_3 - 9.6e-13 47.7 0.9 2.9e-12 46.1 0.9 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DDE_Tnp_1 PF01609.19 MSTRG.1463.3_3 - 0.42 10.1 0.0 0.42 10.1 0.0 2.8 2 1 0 2 2 2 0 Transposase DDE domain Guanylate_cyc PF00211.18 MSTRG.10451.1_3 - 8.1e-10 38.5 0.0 9.5e-10 38.2 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF1053 PF06327.12 MSTRG.10451.1_3 - 0.0084 16.5 0.0 0.015 15.7 0.0 1.4 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1053) UPRTase PF14681.4 MSTRG.6583.4_2 - 1.3e-73 246.7 0.1 1.9e-73 246.2 0.1 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRK PF00485.16 MSTRG.6583.4_2 - 1.6e-61 207.3 0.0 2.3e-61 206.8 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family CPT PF07931.10 MSTRG.6583.4_2 - 2e-06 27.6 0.0 3.7e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.4 MSTRG.6583.4_2 - 2.1e-05 24.9 0.0 4e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.4 MSTRG.6583.4_2 - 0.00026 21.0 0.0 0.00044 20.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.4 MSTRG.6583.4_2 - 0.015 15.6 0.1 3.7 7.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.16 MSTRG.6583.4_2 - 0.024 14.2 0.1 0.51 9.9 0.0 2.1 2 0 0 2 2 2 0 Cytidylate kinase CoaE PF01121.18 MSTRG.6583.4_2 - 0.039 13.5 0.5 0.25 10.9 0.1 2.1 2 0 0 2 2 2 0 Dephospho-CoA kinase CAP_GLY PF01302.23 MSTRG.994.1_3 - 6.2e-22 77.3 0.1 1.1e-21 76.5 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain HTH_26 PF13443.4 MSTRG.994.1_3 - 0.081 13.2 1.6 5.4 7.4 0.2 2.6 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain Reo_sigmaC PF04582.10 MSTRG.994.1_3 - 2.3 7.4 24.5 0.88 8.8 5.5 4.0 2 1 4 6 6 6 0 Reovirus sigma C capsid protein Ank_5 PF13857.4 MSTRG.16619.2_1 - 2.1e-12 46.9 0.0 1.1e-05 25.5 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) LEM PF03020.13 MSTRG.16619.2_1 - 3.5e-07 29.5 0.0 6.5e-07 28.7 0.0 1.5 1 0 0 1 1 1 1 LEM domain Ank_2 PF12796.5 MSTRG.16619.2_1 - 5.4e-06 26.8 0.0 3.7e-05 24.1 0.0 2.2 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Cauli_VI PF01693.14 MSTRG.16619.2_1 - 7.2e-06 26.1 0.1 1.6e-05 25.0 0.1 1.6 1 0 0 1 1 1 1 Caulimovirus viroplasmin Ank_3 PF13606.4 MSTRG.16619.2_1 - 9e-05 22.5 0.1 0.0017 18.6 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.28 MSTRG.16619.2_1 - 0.014 15.7 0.0 0.27 11.6 0.0 2.6 2 0 0 2 2 2 0 Ankyrin repeat Ank_4 PF13637.4 MSTRG.16619.2_1 - 0.057 13.9 0.0 0.19 12.2 0.0 1.9 1 1 0 1 1 1 0 Ankyrin repeats (many copies) DC_STAMP PF07782.11 MSTRG.3668.1_2 - 1.1e-07 31.7 0.1 1.5e-07 31.3 0.1 1.1 1 0 0 1 1 1 1 DC-STAMP-like protein DC_STAMP PF07782.11 MSTRG.3668.1_3 - 8.5e-24 84.3 0.0 1e-23 84.0 0.0 1.1 1 0 0 1 1 1 1 DC-STAMP-like protein Guanylate_cyc PF00211.18 MSTRG.13564.1_2 - 3.1e-66 222.3 0.4 7.3e-66 221.1 0.1 1.7 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.12 MSTRG.13564.1_2 - 2.4e-06 27.0 1.6 3.5e-06 26.5 1.6 1.2 1 0 0 1 1 1 1 Heme NO binding associated Pkinase_Tyr PF07714.15 MSTRG.13564.1_2 - 0.019 14.1 0.1 0.031 13.4 0.1 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase Rhodanese_C PF12368.6 MSTRG.15879.1_3 - 1.1e-15 57.6 9.8 1.1e-15 57.6 9.8 2.1 2 0 0 2 2 2 1 Rhodanase C-terminal PX PF00787.22 MSTRG.5266.2_1 - 5.5e-21 74.5 1.4 5.5e-21 74.5 1.4 2.0 2 0 0 2 2 2 1 PX domain FAM92 PF06730.9 MSTRG.5266.2_1 - 0.00013 21.4 0.1 0.00027 20.3 0.1 1.5 1 0 0 1 1 1 1 FAM92 protein DUF3896 PF13035.4 MSTRG.5266.2_1 - 0.14 12.2 1.7 2.2 8.4 0.4 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3896) TatD_DNase PF01026.19 MSTRG.28614.2_1 - 0.0019 17.5 0.0 0.002 17.4 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase PID PF00640.21 MSTRG.26286.1_3 - 0.062 13.2 0.0 0.13 12.2 0.0 1.5 1 1 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) Phosphorylase PF00343.18 MSTRG.25900.7_3 - 1.2e-153 512.9 1.1 1.4e-153 512.7 1.1 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase FeThRed_B PF02943.13 MSTRG.25900.7_3 - 0.026 14.4 0.9 0.078 12.8 0.9 1.8 1 0 0 1 1 1 0 Ferredoxin thioredoxin reductase catalytic beta chain DUF2115 PF09888.7 MSTRG.25900.7_3 - 0.19 12.1 1.4 0.6 10.5 1.4 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) DUF3246 PF11596.6 MSTRG.13695.3_1 - 0.01 15.1 0.1 0.011 15.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Sec15 PF04091.10 MSTRG.24522.2_3 - 2.3e-93 312.9 0.1 6.8e-93 311.4 0.0 1.8 2 0 0 2 2 2 1 Exocyst complex subunit Sec15-like COG5 PF10392.7 MSTRG.24522.2_3 - 0.00024 21.1 0.7 0.00024 21.1 0.7 2.4 3 0 0 3 3 3 1 Golgi transport complex subunit 5 Sec8_exocyst PF04048.12 MSTRG.24522.2_3 - 0.048 13.4 0.1 0.15 11.9 0.1 1.8 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain COG2 PF06148.9 MSTRG.24522.2_3 - 0.052 13.5 4.1 0.025 14.5 1.2 2.0 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 ATG16 PF08614.9 MSTRG.24522.2_3 - 0.066 13.3 7.4 0.6 10.1 0.6 2.5 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Vps51 PF08700.9 MSTRG.24522.2_3 - 0.093 12.7 1.9 1.8 8.6 0.1 3.4 3 0 0 3 3 3 0 Vps51/Vps67 Sec23_trunk PF04811.13 MSTRG.17680.2_1 - 0.13 11.7 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Sec23/Sec24 trunk domain Cementoin PF10511.7 MSTRG.17680.2_1 - 0.17 11.8 0.8 0.37 10.7 0.8 1.6 1 0 0 1 1 1 0 Trappin protein transglutaminase binding domain RPAP1_C PF08620.8 MSTRG.17680.2_2 - 1.7e-25 88.8 0.2 3.6e-25 87.7 0.2 1.6 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.8 MSTRG.17680.2_2 - 1.8e-14 53.1 3.6 4.9e-14 51.7 3.6 1.8 1 0 0 1 1 1 1 RPAP1-like, N-terminal Tetraspannin PF00335.18 MSTRG.24220.2_3 - 1.1e-28 100.4 6.4 1.4e-28 100.0 6.4 1.2 1 0 0 1 1 1 1 Tetraspanin family ABC2_membrane_2 PF12679.5 MSTRG.24220.2_3 - 0.55 9.3 7.8 1.2 8.2 7.7 1.5 1 1 0 1 1 1 0 ABC-2 family transporter protein NAD_binding_2 PF03446.13 MSTRG.17242.2_3 - 1.4e-47 161.7 1.0 2e-47 161.2 1.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.4 MSTRG.17242.2_3 - 5.6e-35 120.1 0.1 1.9e-34 118.4 0.0 1.8 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 2-Hacid_dh_C PF02826.17 MSTRG.17242.2_3 - 3e-09 36.3 0.0 5.7e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.15 MSTRG.17242.2_3 - 3.5e-07 30.6 0.3 7.2e-07 29.6 0.0 1.7 2 0 0 2 2 1 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.16 MSTRG.17242.2_3 - 0.00087 19.1 0.0 0.0016 18.2 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.10 MSTRG.17242.2_3 - 0.00091 18.7 0.2 0.0016 17.9 0.2 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.16 MSTRG.17242.2_3 - 0.0067 16.5 0.0 0.015 15.5 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain ADH_zinc_N PF00107.24 MSTRG.17242.2_3 - 0.022 14.5 0.2 0.11 12.3 0.0 2.2 3 1 0 3 3 3 0 Zinc-binding dehydrogenase Shikimate_DH PF01488.18 MSTRG.17242.2_3 - 0.028 14.4 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Nitro_FeMo-Co PF02579.15 MSTRG.17242.2_3 - 0.036 14.3 0.1 1 9.6 0.1 2.3 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor PDH PF02153.15 MSTRG.17242.2_3 - 0.075 11.9 0.1 0.11 11.3 0.1 1.3 1 0 0 1 1 1 0 Prephenate dehydrogenase UDPG_MGDP_dh_N PF03721.12 MSTRG.17242.2_3 - 0.13 11.7 0.0 1 8.8 0.0 2.0 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Sacchrp_dh_NADP PF03435.16 MSTRG.17242.2_3 - 0.15 12.2 0.0 0.47 10.6 0.0 1.8 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Profilin PF00235.17 MSTRG.10499.2_3 - 7.4e-22 77.8 0.0 1.3e-21 77.0 0.0 1.4 1 0 0 1 1 1 1 Profilin Lactamase_B PF00753.25 MSTRG.22438.1_2 - 3.6e-18 66.2 1.2 6.4e-18 65.3 1.2 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.5 MSTRG.22438.1_2 - 0.00025 20.5 0.1 0.00035 20.0 0.1 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain COLFI PF01410.16 MSTRG.20339.1_2 - 2e-114 380.6 0.1 2.5e-114 380.3 0.1 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Collagen PF01391.16 MSTRG.20339.1_2 - 8.5e-09 34.9 44.7 1.4e-07 31.0 44.7 2.3 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) Frataxin_Cyay PF01491.14 MSTRG.20339.1_2 - 0.067 13.2 0.0 0.34 10.9 0.0 1.9 2 0 0 2 2 2 0 Frataxin-like domain PDZ PF00595.22 MSTRG.8015.1_2 - 2.8e-61 203.7 3.1 7.1e-16 58.2 0.0 4.3 4 0 0 4 4 4 4 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.8015.1_2 - 3.7e-19 68.7 1.6 0.0029 17.8 0.0 4.4 4 0 0 4 4 4 4 PDZ domain zf-C3HC4 PF00097.23 MSTRG.8015.1_2 - 2.5e-07 30.3 4.8 1.5e-06 27.9 4.8 2.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 MSTRG.8015.1_2 - 7.6e-07 28.7 7.1 7.6e-07 28.7 7.1 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.8015.1_2 - 8e-07 28.8 7.0 8e-07 28.8 7.0 2.9 3 0 0 3 3 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 MSTRG.8015.1_2 - 2.1e-06 27.4 2.0 2.1e-06 27.4 2.0 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.8015.1_2 - 1.1e-05 25.4 5.2 1.1e-05 25.4 5.2 2.8 3 0 0 3 3 1 1 Ring finger domain zf-C3HC4_4 PF15227.4 MSTRG.8015.1_2 - 1.2e-05 25.2 6.7 3.8e-05 23.6 6.7 1.9 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Tricorn_PDZ PF14685.4 MSTRG.8015.1_2 - 7.9e-05 22.5 1.0 1.4 8.9 0.1 4.1 4 0 0 4 4 4 1 Tricorn protease PDZ domain zf-RING_5 PF14634.4 MSTRG.8015.1_2 - 0.00012 21.9 3.8 0.00012 21.9 3.8 2.5 2 0 0 2 2 2 1 zinc-RING finger domain U-box PF04564.13 MSTRG.8015.1_2 - 0.031 14.3 0.0 0.088 12.9 0.0 1.8 1 0 0 1 1 1 0 U-box domain DZR PF12773.5 MSTRG.8015.1_2 - 1.7 8.6 8.5 87 3.1 8.5 2.7 1 1 0 1 1 1 0 Double zinc ribbon Prok-RING_4 PF14447.4 MSTRG.8015.1_2 - 8.7 6.2 12.6 3.4 7.5 8.2 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Adenylsucc_synt PF00709.19 MSTRG.7577.3_1 - 3.5e-181 602.6 0.1 4.1e-181 602.3 0.1 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase Frizzled PF01534.15 MSTRG.1147.1_3 - 1.2e-134 448.3 11.7 1.6e-134 447.9 11.7 1.2 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.20 MSTRG.1147.1_3 - 2e-35 121.7 1.6 3.9e-35 120.8 1.6 1.4 1 0 0 1 1 1 1 Fz domain zf-C2H2 PF00096.24 MSTRG.18209.1_3 - 1.4e-22 78.7 53.6 9.9e-05 22.5 2.8 7.7 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.18209.1_3 - 1.6e-19 69.3 49.2 3e-05 24.1 1.5 7.8 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.18209.1_3 - 2e-16 59.1 47.9 0.0029 18.2 2.2 7.6 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2HC_2 PF13913.4 MSTRG.18209.1_3 - 1.6e-06 27.7 4.5 0.0063 16.3 0.4 4.5 4 0 0 4 4 4 2 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.4 MSTRG.18209.1_3 - 5.2e-05 23.0 41.2 0.025 14.4 3.3 6.9 6 0 0 6 6 6 3 C2H2-type zinc finger zf-Di19 PF05605.10 MSTRG.18209.1_3 - 0.00046 20.3 5.2 0.00046 20.3 5.2 4.3 1 1 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.3 MSTRG.18209.1_3 - 0.0023 17.5 16.1 0.048 13.3 1.5 4.8 4 0 0 4 4 4 2 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 MSTRG.18209.1_3 - 0.0081 16.3 0.3 0.0081 16.3 0.3 5.9 5 1 1 6 6 6 2 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.3 MSTRG.18209.1_3 - 1.4 9.3 19.8 0.54 10.6 0.9 3.9 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger V-set PF07686.15 MSTRG.924.2_3 - 8.7e-18 64.3 0.0 1.6e-17 63.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 MSTRG.924.2_3 - 0.00015 21.7 0.0 0.00037 20.5 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.924.2_3 - 0.00052 20.4 0.0 0.0013 19.2 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 MSTRG.924.2_3 - 0.046 13.7 0.0 0.096 12.6 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin I-set domain Popeye PF04831.11 MSTRG.1447.1_2 - 3.6e-43 147.0 0.1 4.6e-43 146.6 0.1 1.1 1 0 0 1 1 1 1 Popeye protein conserved region cNMP_binding PF00027.27 MSTRG.1447.1_2 - 0.012 15.5 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain Ig_3 PF13927.4 MSTRG.18882.1_2 - 2.7e-17 63.0 0.0 4.2e-17 62.4 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 MSTRG.18882.1_2 - 8.6e-16 57.7 0.0 1.3e-15 57.1 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.18882.1_2 - 8.3e-11 42.0 0.0 1.5e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 MSTRG.18882.1_2 - 3.4e-08 33.4 0.0 9.6e-08 32.0 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 MSTRG.18882.1_2 - 0.00025 21.0 0.0 0.0065 16.5 0.0 2.2 1 1 0 1 1 1 1 Immunoglobulin V-set domain C2-set_2 PF08205.10 MSTRG.18882.1_2 - 0.00072 19.5 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 MSTRG.18882.1_2 - 0.12 12.8 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin C1-set domain zf-H2C2_2 PF13465.4 MSTRG.17544.1_3 - 6.7e-39 130.5 42.1 7.4e-09 35.5 3.1 7.5 7 0 0 7 7 7 7 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.17544.1_3 - 1.3e-27 94.6 54.9 6.9e-06 26.1 1.6 6.8 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.17544.1_3 - 1.2e-24 84.7 47.8 5.6e-05 23.5 0.4 7.1 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.17544.1_3 - 5.2e-12 45.3 38.7 0.016 15.0 0.4 6.5 6 0 0 6 6 6 5 C2H2-type zinc finger zf-H2C2_5 PF13909.4 MSTRG.17544.1_3 - 1.9e-10 40.2 33.9 0.0005 19.6 0.5 6.8 6 0 0 6 6 6 4 C2H2-type zinc-finger domain zf-met PF12874.5 MSTRG.17544.1_3 - 1.8e-06 28.0 32.3 0.011 15.9 2.5 5.9 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.17544.1_3 - 0.001 19.2 1.5 0.027 14.7 0.3 5.9 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 MSTRG.17544.1_3 - 0.0022 18.2 29.1 0.056 13.6 7.4 4.9 1 1 4 5 5 5 4 C2H2 type zinc-finger (2 copies) zinc_ribbon_15 PF17032.3 MSTRG.17544.1_3 - 0.49 11.1 20.5 3.3 8.4 3.1 3.7 1 1 2 3 3 3 0 zinc-ribbon family GAGA PF09237.9 MSTRG.17544.1_3 - 2.2 8.0 16.4 2.5 7.9 0.2 4.3 2 1 3 5 5 5 0 GAGA factor BolA PF01722.16 MSTRG.17544.1_3 - 4 7.7 6.1 17 5.6 0.2 3.3 3 0 0 3 3 3 0 BolA-like protein zf-C2H2_11 PF16622.3 MSTRG.17544.1_3 - 8 6.2 35.5 1 9.0 1.2 6.5 6 0 0 6 6 6 0 zinc-finger C2H2-type zf-AN1 PF01428.14 MSTRG.17544.1_3 - 8.3 6.5 28.8 6.3 6.9 0.5 6.6 6 0 0 6 6 6 0 AN1-like Zinc finger SOGA PF11365.6 MSTRG.3159.1_1 - 9e-55 183.7 10.5 1.5e-28 99.6 3.9 6.4 6 0 0 6 6 6 2 Protein SOGA DUF4482 PF14818.4 MSTRG.3159.1_1 - 5.6e-11 43.3 6.9 5.6e-11 43.3 6.9 7.0 8 0 0 8 8 8 1 Domain of unknown function (DUF4482) Striatin PF08232.10 MSTRG.3159.1_1 - 0.00039 20.9 2.8 0.00039 20.9 2.8 5.1 4 2 0 4 4 4 1 Striatin family TSC22 PF01166.16 MSTRG.3159.1_1 - 0.028 14.6 29.5 0.67 10.2 0.1 6.1 5 0 0 5 5 5 0 TSC-22/dip/bun family Trypsin PF00089.24 MSTRG.17157.1_3 - 6.2e-75 251.7 5.8 7.3e-75 251.4 5.8 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 MSTRG.17157.1_3 - 1.3e-08 35.7 0.1 2.8e-08 34.6 0.1 1.5 2 0 0 2 2 2 1 Trypsin-like peptidase domain DUF1986 PF09342.9 MSTRG.17157.1_3 - 4.3e-07 30.2 0.1 7.7e-07 29.4 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) DUF316 PF03761.13 MSTRG.17157.1_3 - 0.035 13.5 0.0 0.089 12.2 0.0 1.6 1 1 0 1 1 1 0 Chymotrypsin family Peptidase-S1 Fez1 PF06818.13 MSTRG.1991.1_3 - 8.7e-31 107.8 30.8 2.4e-25 90.0 39.7 2.1 1 1 1 2 2 2 2 Fez1 PAS_3 PF08447.10 MSTRG.18011.1_1 - 5.4e-05 23.3 0.0 7.5e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.4 MSTRG.18011.1_1 - 0.001 19.0 0.0 0.0013 18.7 0.0 1.1 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.8 MSTRG.18011.1_1 - 0.023 14.8 0.0 0.031 14.4 0.0 1.2 1 0 0 1 1 1 0 PAS fold PAS_9 PF13426.5 MSTRG.18011.1_1 - 0.087 13.0 0.0 0.11 12.6 0.0 1.1 1 0 0 1 1 1 0 PAS domain SRF-TF PF00319.16 MSTRG.4660.5_1 - 1.9e-23 81.5 0.4 3.9e-23 80.5 0.4 1.6 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.6 MSTRG.4660.5_1 - 1.4e-22 79.3 0.8 3.9e-22 77.9 0.8 1.8 1 0 0 1 1 1 1 Holliday junction regulator protein family C-terminal repeat K_channel_TID PF07941.9 MSTRG.4660.5_3 - 0.16 12.3 5.2 0.45 10.9 5.2 1.7 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain HMG_box PF00505.17 MSTRG.13173.2_3 - 5e-18 65.2 0.8 1.2e-17 63.9 0.8 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 MSTRG.13173.2_3 - 1.9e-05 25.0 0.3 4.9e-05 23.7 0.3 1.7 1 0 0 1 1 1 1 HMG-box domain GCN5L1 PF06320.11 MSTRG.13173.2_3 - 0.006 16.6 1.8 0.016 15.2 1.8 1.7 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) Radical_SAM_C PF16199.3 MSTRG.25641.1_2 - 4.1e-34 116.3 0.0 8.6e-34 115.3 0.0 1.6 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.19 MSTRG.25641.1_2 - 2.9e-21 76.4 0.7 8e-21 75.0 0.1 2.0 3 0 0 3 3 3 1 Radical SAM superfamily Acetyltransf_1 PF00583.23 MSTRG.25641.1_2 - 4.1e-09 36.6 0.0 7.3e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.5 MSTRG.25641.1_2 - 5.1e-05 23.1 0.0 9.9e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.5 MSTRG.25641.1_2 - 0.034 14.4 0.0 0.09 13.1 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain BTB_2 PF02214.20 MSTRG.10206.2_1 - 1.3e-05 25.3 0.0 2.3e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB_2 PF02214.20 MSTRG.10206.2_3 - 3.7e-10 39.9 0.0 6.7e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain TMEM154 PF15102.4 MSTRG.19692.2_1 - 0.00012 21.9 0.0 0.0002 21.2 0.0 1.2 1 0 0 1 1 1 1 TMEM154 protein family MHC_I PF00129.16 MSTRG.19692.2_3 - 3.1e-37 127.7 3.7 4.3e-37 127.3 3.7 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 MSTRG.19692.2_3 - 2.5e-09 37.4 0.0 5.4e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain ERM PF00769.17 MSTRG.5176.1_2 - 0.0084 15.8 12.7 0.0084 15.8 12.7 1.9 2 0 0 2 2 2 1 Ezrin/radixin/moesin family V-ATPase_C PF03223.13 MSTRG.5176.1_2 - 0.19 11.0 7.2 0.27 10.4 7.2 1.1 1 0 0 1 1 1 0 V-ATPase subunit C DASH_Hsk3 PF08227.9 MSTRG.5176.1_2 - 0.84 9.9 5.9 21 5.4 0.1 3.4 3 0 0 3 3 3 0 DASH complex subunit Hsk3 like PH PF00169.27 MSTRG.10750.1_1 - 1.5e-15 57.5 1.2 3.5e-15 56.3 0.1 2.3 3 0 0 3 3 3 1 PH domain PH_11 PF15413.4 MSTRG.10750.1_1 - 0.00011 22.4 0.5 0.00045 20.5 0.5 2.1 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.4 MSTRG.10750.1_1 - 0.0002 21.4 0.1 0.00051 20.1 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain MAP7 PF05672.9 MSTRG.15368.3_2 - 7.2e-47 159.0 78.1 7.2e-47 159.0 78.1 3.4 3 0 0 3 3 3 1 MAP7 (E-MAP-115) family zf-C4 PF00105.16 MSTRG.20753.1_2 - 3.1e-31 107.5 11.8 1.1e-30 105.7 11.8 2.0 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 MSTRG.20753.1_2 - 1.3e-17 64.0 2.2 1.3e-17 64.0 2.2 1.7 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor HELP PF03451.12 MSTRG.17702.1_2 - 1.1e-29 101.9 0.0 2.1e-29 101.0 0.0 1.5 1 0 0 1 1 1 1 HELP motif WD40 PF00400.30 MSTRG.17702.1_2 - 9.4e-24 83.1 38.0 9.6e-05 23.0 0.0 11.2 12 0 0 12 12 12 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.17702.1_2 - 1.4e-05 25.2 0.8 0.038 14.1 0.0 4.6 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain PKcGMP_CC PF16808.3 MSTRG.17702.1_2 - 0.0081 15.9 0.4 0.015 15.0 0.4 1.4 1 0 0 1 1 1 1 Coiled-coil N-terminus of cGMP-dependent protein kinase SlyX PF04102.10 MSTRG.17702.1_2 - 0.31 11.6 1.2 0.57 10.7 1.2 1.3 1 0 0 1 1 1 0 SlyX Kringle PF00051.16 MSTRG.15074.2_3 - 2.7e-143 466.4 71.2 4e-29 100.6 9.3 5.5 5 0 0 5 5 5 5 Kringle domain Trypsin PF00089.24 MSTRG.15074.2_3 - 2.1e-67 227.0 0.3 5.5e-67 225.7 0.3 1.8 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 MSTRG.15074.2_3 - 4.2e-09 37.3 0.0 9.7e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain PAN_1 PF00024.24 MSTRG.15074.2_3 - 6.2e-09 35.6 1.7 6.2e-09 35.6 1.7 2.4 2 0 0 2 2 2 1 PAN domain DUF1986 PF09342.9 MSTRG.15074.2_3 - 3.4e-07 30.5 0.0 6.4e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) FBA PF04300.11 MSTRG.15074.2_3 - 0.058 13.1 0.2 8.1 6.1 0.0 3.0 3 0 0 3 3 3 0 F-box associated region DUF3719 PF12516.6 MSTRG.15074.2_3 - 0.17 11.5 1.9 73 3.1 0.0 4.4 4 0 0 4 4 4 0 Protein of unknown function (DUF3719) SR-25 PF10500.7 MSTRG.19398.1_2 - 2.3 7.6 101.5 0.06 12.8 65.6 2.2 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein GST_N_3 PF13417.4 MSTRG.10794.1_2 - 9.9e-13 48.2 0.0 1.8e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.4 MSTRG.10794.1_2 - 9.1e-12 44.9 0.0 1.6e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 MSTRG.10794.1_2 - 1.5e-10 40.8 0.0 3e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.4 MSTRG.10794.1_2 - 2e-10 40.7 0.0 3.4e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.18 MSTRG.10794.1_2 - 1.1e-08 35.1 0.0 1.9e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 MSTRG.10794.1_2 - 1.9e-07 31.1 0.1 2.9e-07 30.5 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.3 MSTRG.10794.1_2 - 0.0057 17.1 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Pkinase_Tyr PF07714.15 MSTRG.2786.1_2 - 1e-61 208.4 0.0 1.2e-61 208.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.2786.1_2 - 7.3e-57 192.6 0.0 9.2e-57 192.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.21 MSTRG.2786.1_2 - 0.004 17.0 0.0 0.0077 16.0 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.4 MSTRG.2786.1_2 - 0.066 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 ZZ PF00569.15 MSTRG.2049.2_3 - 5.3e-18 64.4 4.7 1e-17 63.5 4.7 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type EF-hand_3 PF09069.9 MSTRG.2049.2_3 - 7.2e-11 42.2 0.6 1.6e-10 41.1 0.6 1.6 1 0 0 1 1 1 1 EF-hand DUF4600 PF15372.4 MSTRG.2049.2_3 - 0.0058 16.9 2.2 0.53 10.6 0.4 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4600) Miff PF05644.9 MSTRG.2049.2_3 - 0.013 15.0 1.7 0.025 14.1 1.7 1.4 1 1 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff SOGA PF11365.6 MSTRG.2049.2_3 - 0.017 16.1 7.0 0.54 11.3 0.5 2.4 1 1 1 2 2 2 0 Protein SOGA Rootletin PF15035.4 MSTRG.2049.2_3 - 0.08 12.9 7.8 0.15 12.0 1.5 2.2 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF972 PF06156.11 MSTRG.2049.2_3 - 0.44 11.1 5.5 7.4 7.1 0.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF972) RasGAP_C PF03836.13 MSTRG.2049.2_3 - 0.45 10.5 2.5 3.1 7.8 0.0 2.2 2 0 0 2 2 2 0 RasGAP C-terminus Spc24 PF08286.9 MSTRG.2049.2_3 - 0.74 9.9 6.5 0.6 10.2 1.5 2.4 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 TBPIP PF07106.11 MSTRG.2049.2_3 - 1 9.0 4.5 1.9 8.1 0.9 2.2 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) HALZ PF02183.16 MSTRG.2049.2_3 - 1.1 9.4 13.4 0.91 9.6 3.9 2.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper Cep57_MT_bd PF06657.11 MSTRG.2049.2_3 - 1.4 9.3 6.6 0.28 11.5 0.5 2.4 3 0 0 3 3 2 0 Centrosome microtubule-binding domain of Cep57 bZIP_1 PF00170.19 MSTRG.2049.2_3 - 1.6 8.8 10.6 1.9 8.5 0.7 2.5 2 0 0 2 2 2 0 bZIP transcription factor ADIP PF11559.6 MSTRG.2049.2_3 - 2.4 8.1 10.2 9.9 6.1 3.2 2.3 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Prefoldin_2 PF01920.18 MSTRG.2049.2_3 - 3.1 7.7 8.5 13 5.7 3.3 2.4 2 0 0 2 2 2 0 Prefoldin subunit LRRFIP PF09738.7 MSTRG.2049.2_3 - 3.3 7.0 10.8 4.9 6.4 2.1 2.2 1 1 1 2 2 2 0 LRRFIP family Tropomyosin_1 PF12718.5 MSTRG.2049.2_3 - 3.7 7.6 9.6 19 5.2 4.0 2.2 2 0 0 2 2 2 0 Tropomyosin like IncA PF04156.12 MSTRG.2049.2_3 - 4.1 7.0 9.1 13 5.3 3.2 2.1 2 0 0 2 2 2 0 IncA protein APG6 PF04111.10 MSTRG.2049.2_3 - 4.3 6.5 8.3 14 4.8 8.0 1.6 1 1 0 1 1 1 0 Autophagy protein Apg6 ZapB PF06005.10 MSTRG.2049.2_3 - 6.6 7.1 14.0 16 5.9 0.9 2.4 2 0 0 2 2 2 0 Cell division protein ZapB Nnf1 PF03980.12 MSTRG.2049.2_3 - 7.4 6.9 11.5 22 5.4 9.3 2.3 1 1 1 2 2 2 0 Nnf1 Spc7 PF08317.9 MSTRG.2049.2_3 - 9.8 4.8 7.2 26 3.4 7.2 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein Annexin PF00191.18 MSTRG.4003.2_1 - 1.6e-99 325.9 12.0 2e-26 91.7 0.4 4.2 4 0 0 4 4 4 4 Annexin Ribosomal_L27 PF01016.17 MSTRG.8668.1_2 - 2.2e-22 78.7 0.2 3.5e-22 78.1 0.2 1.2 1 0 0 1 1 1 1 Ribosomal L27 protein G-alpha PF00503.18 MSTRG.19660.1_1 - 1.3e-115 386.2 3.3 1.8e-115 385.8 3.3 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 MSTRG.19660.1_1 - 1.3e-14 53.9 1.1 1.8e-11 43.7 0.3 2.6 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 MSTRG.19660.1_1 - 0.0001 21.6 0.3 0.006 15.8 0.1 2.3 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region AAA_29 PF13555.4 MSTRG.19660.1_1 - 0.05 13.2 0.1 1.1 8.9 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain Roc PF08477.11 MSTRG.19660.1_1 - 0.11 12.6 0.1 8.2 6.6 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF258 PF03193.14 MSTRG.19660.1_1 - 0.12 12.2 0.0 0.54 10.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 MSTRG.19660.1_1 - 0.15 11.4 0.0 0.89 8.9 0.0 2.0 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain F_actin_cap_B PF01115.15 MSTRG.13958.1_1 - 2.1e-108 361.3 0.0 2.7e-108 361.0 0.0 1.1 1 0 0 1 1 1 1 F-actin capping protein, beta subunit RhoGEF PF00621.18 MSTRG.25870.1_3 - 7.9e-32 110.8 5.6 1.2e-31 110.2 5.6 1.3 1 0 0 1 1 1 1 RhoGEF domain SH3_1 PF00018.26 MSTRG.25870.1_3 - 5.7e-11 41.7 0.1 1.2e-10 40.7 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.25870.1_3 - 6.7e-11 41.7 0.0 1.5e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.25870.1_3 - 5.9e-08 32.2 0.1 1.1e-07 31.2 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.27 MSTRG.25870.1_3 - 6.4e-05 23.3 0.0 0.00015 22.1 0.0 1.6 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.3 MSTRG.25870.1_3 - 0.0026 17.6 0.0 0.0058 16.5 0.0 1.5 1 0 0 1 1 1 1 PH domain SH2 PF00017.22 MSTRG.23248.1_3 - 1.3e-19 69.9 0.0 2.5e-19 69.0 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 MSTRG.23248.1_3 - 0.00035 20.0 0.0 0.00066 19.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain eIF_4EBP PF05456.9 MSTRG.3995.2_2 - 4.5e-40 136.0 2.0 5.9e-40 135.7 2.0 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) NST1 PF13945.4 MSTRG.1236.5_3 - 0.13 12.2 2.2 0.19 11.7 2.2 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator Histone_H2A_C PF16211.3 MSTRG.28122.1_2 - 1.7e-21 75.5 8.1 5.1e-21 74.0 1.9 2.9 3 0 0 3 3 3 2 C-terminus of histone H2A Histone PF00125.22 MSTRG.28122.1_2 - 0.00097 19.4 0.1 0.0013 18.9 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Arm PF00514.21 MSTRG.21519.1_1 - 6.7e-21 73.5 9.6 5.7e-08 32.4 0.1 7.3 7 0 0 7 7 7 6 Armadillo/beta-catenin-like repeat MNR PF15718.3 MSTRG.21178.2_3 - 1.5e-62 212.0 10.1 9.5e-58 196.1 10.1 3.0 1 1 0 1 1 1 1 Protein moonraker BTB PF00651.29 MSTRG.10789.2_2 - 5.3e-26 90.9 0.1 8.6e-26 90.2 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_5 PF13909.4 MSTRG.10789.2_2 - 6.8e-08 32.0 2.7 6.8e-08 32.0 2.7 2.1 2 0 0 2 2 2 1 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.4 MSTRG.10789.2_2 - 7e-07 29.3 4.2 7e-07 29.3 4.2 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.10789.2_2 - 1.6e-05 25.0 1.3 1.6e-05 25.0 1.3 4.0 4 0 0 4 4 4 1 Zinc finger, C2H2 type DUF3342 PF11822.6 MSTRG.10789.2_2 - 0.00019 21.4 0.0 0.00035 20.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) zf-C2H2_4 PF13894.4 MSTRG.10789.2_2 - 0.00025 21.5 1.4 0.00025 21.5 1.4 4.6 4 0 0 4 4 4 1 C2H2-type zinc finger zf-met PF12874.5 MSTRG.10789.2_2 - 0.02 15.2 0.1 0.02 15.2 0.1 4.4 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 MSTRG.10789.2_2 - 0.076 12.9 0.3 0.076 12.9 0.3 2.8 3 0 0 3 3 3 0 C2H2-type zinc finger Lar_restr_allev PF14354.4 MSTRG.10789.2_2 - 0.11 12.8 7.0 0.22 11.8 2.0 2.7 2 1 0 2 2 2 0 Restriction alleviation protein Lar zf-Di19 PF05605.10 MSTRG.10789.2_2 - 0.68 10.1 10.9 0.47 10.6 2.4 2.4 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding CH PF00307.29 MSTRG.7174.4_1 - 2.1e-24 85.6 0.1 4.3e-18 65.4 0.0 2.3 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.6 MSTRG.7174.4_1 - 1.5e-05 24.6 0.2 0.0001 21.9 0.1 2.2 2 0 0 2 2 2 1 CAMSAP CH domain DUF4795 PF16043.3 MSTRG.7174.4_1 - 0.04 13.4 0.1 0.13 11.7 0.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) DUF1664 PF07889.10 MSTRG.7174.4_1 - 0.11 12.3 0.7 0.22 11.4 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF2205 PF10224.7 MSTRG.7174.4_1 - 0.13 12.1 0.1 0.31 10.9 0.1 1.6 1 0 0 1 1 1 0 Predicted coiled-coil protein (DUF2205) ARID PF01388.19 MSTRG.25107.1_2 - 5.3e-21 74.9 0.1 1.1e-20 73.9 0.1 1.6 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain NOA36 PF06524.10 MSTRG.25107.1_2 - 4.4 6.5 8.0 8.1 5.6 8.0 1.3 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.11 MSTRG.25107.1_2 - 4.7 5.1 9.3 7.6 4.4 9.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi TFIIA PF03153.11 MSTRG.25107.1_2 - 7.5 6.3 28.8 0.79 9.5 10.9 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RhoGEF PF00621.18 MSTRG.27666.2_1 - 1.5e-35 123.0 0.2 2.6e-35 122.2 0.2 1.4 1 0 0 1 1 1 1 RhoGEF domain DUF1126 PF06565.10 MSTRG.27666.2_1 - 0.037 13.7 0.5 1.9 8.2 0.0 2.9 3 0 0 3 3 3 0 DUF1126 PH-like domain DGCR6 PF07324.9 MSTRG.22596.1_1 - 0.004 16.7 2.5 0.011 15.2 2.2 2.0 1 1 0 1 1 1 1 DiGeorge syndrome critical region 6 (DGCR6) protein DUF438 PF04282.11 MSTRG.22596.1_1 - 0.018 14.8 0.9 0.056 13.3 0.1 2.3 3 0 0 3 3 3 0 Family of unknown function (DUF438) Rhodanese PF00581.18 MSTRG.29227.1_3 - 7.1e-08 32.8 0.0 1e-07 32.3 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain PEN-2 PF10251.7 MSTRG.17153.1_2 - 3.1e-39 133.1 2.1 4.8e-39 132.5 2.1 1.3 1 0 0 1 1 1 1 Presenilin enhancer-2 subunit of gamma secretase SPRY PF00622.26 MSTRG.13677.1_3 - 1.2e-25 89.8 0.1 3.6e-25 88.3 0.1 1.8 2 0 0 2 2 2 1 SPRY domain zf-C3HC4_3 PF13920.4 MSTRG.13677.1_3 - 1.7e-08 34.0 8.6 1.7e-08 34.0 8.6 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.13677.1_3 - 0.0026 17.9 11.2 0.0026 17.9 11.2 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.4 MSTRG.13677.1_3 - 0.0033 17.1 12.3 0.015 15.0 12.3 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 MSTRG.13677.1_3 - 0.024 14.4 14.0 0.08 12.7 14.0 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 MSTRG.13677.1_3 - 0.059 13.2 10.5 0.23 11.3 10.5 2.1 1 0 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.4 MSTRG.13677.1_3 - 0.32 10.7 14.4 0.079 12.7 9.5 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.4 MSTRG.13677.1_3 - 3.7 7.5 11.5 10 6.1 11.5 1.9 1 0 0 1 1 1 0 RING-type zinc-finger TRAPP PF04051.14 MSTRG.14672.1_3 - 0.0073 15.9 0.0 0.0082 15.7 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component RRM_1 PF00076.20 MSTRG.2562.2_3 - 7.4e-17 60.8 0.0 1.2e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.2562.2_3 - 0.0012 18.8 0.0 0.0022 17.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif Limkain-b1 PF11608.6 MSTRG.2562.2_3 - 0.0023 17.8 0.0 0.005 16.8 0.0 1.5 1 0 0 1 1 1 1 Limkain b1 RRM_3 PF08777.9 MSTRG.2562.2_3 - 0.012 15.5 0.0 0.024 14.5 0.0 1.5 1 0 0 1 1 1 0 RNA binding motif RRM_occluded PF16842.3 MSTRG.2562.2_3 - 0.022 14.5 0.0 0.035 13.8 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif RRM_5 PF13893.4 MSTRG.2562.2_3 - 0.045 13.2 0.0 0.082 12.4 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 MSTRG.2562.2_3 - 0.066 13.1 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RAP1 PF07218.9 MSTRG.2562.2_3 - 0.45 8.6 11.4 0.57 8.3 11.4 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Macoilin PF09726.7 MSTRG.2562.2_3 - 2.3 6.5 12.2 3.6 5.9 12.2 1.3 1 0 0 1 1 1 0 Transmembrane protein FAM199X PF15814.3 MSTRG.2562.2_3 - 3.5 6.5 14.1 5.6 5.8 14.1 1.3 1 0 0 1 1 1 0 Protein family FAM199X Menin PF05053.11 MSTRG.2562.2_3 - 5.6 5.1 8.6 7.2 4.7 8.6 1.1 1 0 0 1 1 1 0 Menin MTS PF05175.12 MSTRG.20135.1_2 - 6.2e-08 32.2 0.0 1.2e-07 31.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.4 MSTRG.20135.1_2 - 0.0065 17.0 0.0 0.011 16.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.7 MSTRG.20135.1_2 - 0.039 13.6 0.0 0.057 13.0 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Ribonuc_red_sm PF00268.19 MSTRG.23408.1_1 - 7.9e-123 409.2 2.6 9.9e-123 408.9 2.6 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain C1_1 PF00130.20 MSTRG.23148.2_1 - 5.7e-08 32.4 15.0 3.7e-07 29.8 10.5 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.14 MSTRG.23148.2_1 - 0.00087 19.4 10.9 0.0066 16.6 3.6 2.6 2 0 0 2 2 2 2 C1 domain DUF3435 PF11917.6 MSTRG.23148.2_1 - 0.025 13.4 0.0 0.03 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) DZR PF12773.5 MSTRG.23148.2_1 - 6.2 6.8 11.6 2e+03 -1.2 11.6 2.6 1 1 0 1 1 1 0 Double zinc ribbon zf-H2C2_2 PF13465.4 MSTRG.16183.1_3 - 4.7e-41 137.3 41.8 9.9e-10 38.3 1.1 7.7 8 0 0 8 8 7 6 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.16183.1_3 - 1.1e-27 94.8 43.3 1.4e-05 25.1 0.5 7.0 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.16183.1_3 - 2.8e-22 77.3 37.2 0.00013 22.3 0.4 7.0 7 0 0 7 7 6 6 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.16183.1_3 - 2.2e-11 43.3 31.6 0.00016 21.4 0.3 6.8 6 1 0 6 6 6 3 C2H2-type zinc finger zf-Di19 PF05605.10 MSTRG.16183.1_3 - 1.5e-08 34.6 13.7 0.0013 18.8 0.4 3.9 3 0 0 3 3 3 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.6 MSTRG.16183.1_3 - 3.7e-06 27.0 13.7 0.3 11.3 0.0 5.8 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.16183.1_3 - 3.7e-05 23.8 3.5 0.0035 17.5 0.3 6.6 7 1 0 7 7 7 2 Zinc-finger of C2H2 type C1_1 PF00130.20 MSTRG.16183.1_3 - 0.00063 19.5 14.4 0.17 11.7 2.2 4.4 2 2 1 4 4 4 3 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc_ribbon_15 PF17032.3 MSTRG.16183.1_3 - 0.0046 17.5 14.9 0.66 10.6 1.7 4.2 2 1 3 5 5 5 3 zinc-ribbon family zf-H2C2_5 PF13909.4 MSTRG.16183.1_3 - 0.0067 16.0 37.3 3.8 7.2 10.3 7.3 6 1 0 6 6 6 2 C2H2-type zinc-finger domain Elf1 PF05129.11 MSTRG.16183.1_3 - 0.0077 16.1 17.2 0.074 13.0 0.9 4.3 1 1 3 4 4 4 2 Transcription elongation factor Elf1 like LIM PF00412.20 MSTRG.16183.1_3 - 0.038 14.1 18.2 4.8 7.4 4.6 5.1 1 1 4 5 5 5 0 LIM domain BolA PF01722.16 MSTRG.16183.1_3 - 0.12 12.5 4.6 16 5.8 0.9 3.8 1 1 1 2 2 2 0 BolA-like protein PHD_4 PF16866.3 MSTRG.16183.1_3 - 0.17 11.9 9.4 13 5.9 0.3 4.4 1 1 5 6 6 6 0 PHD-finger zf-UBP PF02148.17 MSTRG.16183.1_3 - 0.24 11.6 15.0 8.8 6.6 0.5 4.5 1 1 2 3 3 3 0 Zn-finger in ubiquitin-hydrolases and other protein Zn-ribbon_8 PF09723.8 MSTRG.16183.1_3 - 0.32 11.0 20.2 3.7 7.6 1.0 5.4 4 2 1 5 5 5 0 Zinc ribbon domain DUF3268 PF11672.6 MSTRG.16183.1_3 - 0.39 10.9 6.9 5.2 7.3 0.2 3.1 2 1 0 3 3 3 0 zinc-finger-containing domain zf-C2H2_2 PF12756.5 MSTRG.16183.1_3 - 0.7 10.1 19.9 0.2 11.9 3.9 5.5 2 1 3 5 5 5 0 C2H2 type zinc-finger (2 copies) C1_4 PF07975.10 MSTRG.16183.1_3 - 0.76 10.0 14.1 2.4 8.4 2.0 3.8 2 1 2 4 4 4 0 TFIIH C1-like domain Prok-RING_1 PF14446.4 MSTRG.16183.1_3 - 0.99 9.3 13.8 8.3 6.3 0.0 6.0 6 0 0 6 6 6 0 Prokaryotic RING finger family 1 DUF2256 PF10013.7 MSTRG.16183.1_3 - 1.3 9.1 18.6 35 4.5 0.1 6.0 6 0 0 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-LYAR PF08790.9 MSTRG.16183.1_3 - 1.6 8.6 22.5 5.4 6.9 0.2 6.4 6 0 0 6 6 6 0 LYAR-type C2HC zinc finger zf-AN1 PF01428.14 MSTRG.16183.1_3 - 1.7 8.8 21.8 31 4.7 0.1 6.3 6 0 0 6 6 6 0 AN1-like Zinc finger CpXC PF14353.4 MSTRG.16183.1_3 - 3.4 7.6 11.9 11 6.0 0.1 5.0 4 2 2 6 6 6 0 CpXC protein zf-C2H2_11 PF16622.3 MSTRG.16183.1_3 - 4.7 6.9 26.4 3.7 7.2 0.3 6.0 6 0 0 6 6 6 0 zinc-finger C2H2-type zinc_ribbon_4 PF13717.4 MSTRG.16183.1_3 - 9.1 6.2 13.9 66 3.4 0.1 5.2 5 0 0 5 5 5 0 zinc-ribbon domain DUF4462 PF14692.4 MSTRG.14655.2_1 - 0.067 12.7 1.5 12 5.5 2.8 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4462) DENN PF02141.19 MSTRG.319.2_2 - 2.9e-47 160.9 4.9 2.9e-47 160.9 4.9 1.9 2 0 0 2 2 2 1 DENN (AEX-3) domain uDENN PF03456.16 MSTRG.319.2_2 - 5.4e-11 43.0 1.0 2e-10 41.2 1.0 2.0 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.17 MSTRG.319.2_2 - 2.2e-10 40.2 1.4 7.6e-10 38.5 1.4 2.0 1 0 0 1 1 1 1 dDENN domain Gelsolin PF00626.20 MSTRG.25880.1_1 - 1e-40 137.4 0.0 9e-15 54.2 0.0 3.5 3 0 0 3 3 3 3 Gelsolin repeat PRY PF13765.4 MSTRG.25880.1_2 - 4.4e-16 58.1 0.0 1.1e-15 56.8 0.0 1.8 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 MSTRG.25880.1_2 - 2.7e-14 53.2 0.0 5e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 SPRY domain ApoLp-III PF07464.9 MSTRG.25880.1_2 - 0.028 14.4 0.9 0.099 12.6 0.9 1.8 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) DUF1899 PF08953.9 MSTRG.24045.1_1 - 8.9e-31 105.5 0.1 1.6e-30 104.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.3 MSTRG.24045.1_1 - 2.7e-21 75.0 0.1 5.9e-21 73.9 0.1 1.6 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.30 MSTRG.24045.1_1 - 1.6e-12 47.6 4.4 0.003 18.2 0.3 4.7 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.24045.1_1 - 2e-05 24.7 0.1 0.074 13.2 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Trimer_CC PF08954.9 MSTRG.24045.1_1 - 0.0013 18.1 0.2 0.24 10.8 0.2 3.0 2 0 0 2 2 2 1 Trimerisation motif Tweety PF04906.11 MSTRG.5265.3_2 - 8.1e-93 311.1 8.2 8.1e-93 311.1 8.2 1.6 2 0 0 2 2 2 1 Tweety TMEM132D_C PF15706.3 MSTRG.5265.3_3 - 0.56 9.9 4.6 1.1 8.9 4.6 1.4 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term FAM92 PF06730.9 MSTRG.6718.1_1 - 1.6e-51 174.7 4.6 2.1e-51 174.4 4.6 1.0 1 0 0 1 1 1 1 FAM92 protein BAR_3 PF16746.3 MSTRG.6718.1_1 - 0.00015 21.4 0.3 0.0002 21.0 0.3 1.2 1 0 0 1 1 1 1 BAR domain of APPL family Conotoxin PF02950.15 MSTRG.6718.1_1 - 0.0013 19.5 0.1 0.0013 19.5 0.1 2.5 3 0 0 3 3 3 1 Conotoxin ATP-synt_B PF00430.16 MSTRG.6718.1_1 - 0.0015 18.5 1.5 0.0015 18.5 1.5 1.8 1 1 1 2 2 2 1 ATP synthase B/B' CF(0) RMI1_C PF16099.3 MSTRG.6718.1_1 - 0.013 15.2 0.3 0.034 13.9 0.3 1.8 1 1 0 1 1 1 0 Recq-mediated genome instability protein 1, C-terminal OB-fold TPD52 PF04201.13 MSTRG.6718.1_1 - 0.02 14.4 0.2 0.056 12.9 0.2 1.6 1 1 0 1 1 1 0 Tumour protein D52 family DUF4407 PF14362.4 MSTRG.6718.1_1 - 0.035 13.3 4.5 0.055 12.7 4.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SH3-RhoG_link PF16609.3 MSTRG.12031.1_1 - 0.027 14.1 1.9 0.032 13.8 1.9 1.1 1 0 0 1 1 1 0 SH3-RhoGEF linking unstructured region EGF PF00008.25 MSTRG.12031.1_3 - 2.7e-19 69.0 31.1 5.9e-10 39.1 7.7 3.3 3 0 0 3 3 3 3 EGF-like domain hEGF PF12661.5 MSTRG.12031.1_3 - 6.9e-07 29.6 35.1 0.00013 22.3 8.1 3.9 4 0 0 4 4 4 3 Human growth factor-like EGF EGF_2 PF07974.11 MSTRG.12031.1_3 - 6.4e-06 26.3 37.4 0.00024 21.3 7.3 3.1 3 0 0 3 3 3 2 EGF-like domain EGF_CA PF07645.13 MSTRG.12031.1_3 - 0.00066 19.7 33.0 0.16 12.0 6.2 3.4 2 2 1 3 3 3 3 Calcium-binding EGF domain Plasmod_Pvs28 PF06247.9 MSTRG.12031.1_3 - 0.37 11.0 20.4 0.1 12.8 3.1 2.8 3 0 0 3 3 3 0 Pvs28 EGF domain Laminin_EGF PF00053.22 MSTRG.12031.1_3 - 2.8 8.0 28.9 1.2 9.2 7.0 2.8 1 1 1 2 2 2 0 Laminin EGF domain EGF_3 PF12947.5 MSTRG.12031.1_3 - 3.6 7.7 34.5 1.9 8.6 6.0 4.0 2 1 1 3 3 3 0 EGF domain Ig_3 PF13927.4 MSTRG.4318.5_1 - 3.7e-08 33.7 0.5 0.0011 19.4 0.0 3.1 2 1 1 3 3 3 2 Immunoglobulin domain C1-set PF07654.13 MSTRG.4318.5_1 - 2.1e-06 27.9 0.2 5.5e-06 26.6 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin C1-set domain C2-set_2 PF08205.10 MSTRG.4318.5_1 - 5.9e-06 26.1 0.6 4.3e-05 23.4 0.2 2.4 1 1 1 2 2 2 1 CD80-like C2-set immunoglobulin domain I-set PF07679.14 MSTRG.4318.5_1 - 6.5e-06 26.0 0.5 0.00058 19.7 0.0 2.7 2 1 0 3 3 3 1 Immunoglobulin I-set domain ig PF00047.23 MSTRG.4318.5_1 - 0.0022 18.0 0.9 3 7.9 0.0 2.7 3 0 0 3 3 3 2 Immunoglobulin domain DUF4725 PF15854.3 MSTRG.4318.5_1 - 0.012 15.6 5.0 0.5 10.5 0.2 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4725) SIT PF15330.4 MSTRG.4318.5_1 - 0.023 15.0 0.0 0.023 15.0 0.0 1.7 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT EphA2_TM PF14575.4 MSTRG.4318.5_1 - 0.065 13.9 1.8 0.13 13.0 0.0 2.1 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF4381 PF14316.4 MSTRG.4318.5_1 - 0.069 13.3 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Afaf PF15339.4 MSTRG.4318.5_1 - 0.7 9.5 0.0 0.7 9.5 0.0 1.9 2 0 0 2 2 2 0 Acrosome formation-associated factor V-set PF07686.15 MSTRG.18922.1_1 - 1.2e-05 25.3 0.4 3.8e-05 23.7 0.4 1.9 1 1 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 MSTRG.18922.1_1 - 0.00024 21.1 1.0 0.00089 19.3 1.0 2.0 1 1 0 1 1 1 1 Immunoglobulin domain DUF4366 PF14283.4 MSTRG.18922.1_1 - 0.0029 17.0 0.5 0.077 12.3 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4366) Ig_3 PF13927.4 MSTRG.18922.1_1 - 0.0055 17.2 0.5 0.023 15.2 0.5 2.1 1 1 0 1 1 1 1 Immunoglobulin domain Orn_Arg_deC_N PF02784.14 MSTRG.1681.1_1 - 2.7e-86 288.9 0.0 3.4e-86 288.6 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 MSTRG.1681.1_1 - 1.6e-35 121.4 0.1 5.3e-35 119.7 0.0 1.8 2 0 0 2 2 2 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.22 MSTRG.1681.1_1 - 0.0045 16.3 0.0 0.0087 15.4 0.0 1.4 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Cullin_binding PF03556.13 MSTRG.12117.1_1 - 3.4e-36 124.1 1.5 3.4e-36 124.1 1.5 1.6 2 0 0 2 2 2 1 Cullin binding UBA_4 PF14555.4 MSTRG.12117.1_1 - 6.7e-10 38.5 0.1 2.7e-09 36.6 0.0 2.1 2 0 0 2 2 2 1 UBA-like domain DUF2493 PF10686.7 MSTRG.29380.1_2 - 0.015 15.1 0.2 0.031 14.1 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2493) OCRL_clath_bd PF16726.3 MSTRG.7453.1_2 - 1.4e-41 140.8 0.1 2.7e-41 139.8 0.1 1.5 1 0 0 1 1 1 1 Inositol polyphosphate 5-phosphatase clathrin binding domain RhoGAP PF00620.25 MSTRG.7453.1_2 - 2.1e-24 85.9 0.1 3.6e-24 85.2 0.1 1.4 1 0 0 1 1 1 1 RhoGAP domain Exo_endo_phos PF03372.21 MSTRG.7453.1_2 - 4e-10 39.8 0.1 7.9e-10 38.9 0.1 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family INPP5B_PH PF16776.3 MSTRG.7453.1_2 - 0.026 14.1 0.0 0.056 13.1 0.0 1.4 1 0 0 1 1 1 0 Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain Elongin_A PF06881.9 MSTRG.7874.2_2 - 2.7e-26 92.0 0.5 5.5e-26 91.0 0.5 1.5 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Med26 PF08711.9 MSTRG.7874.2_2 - 8.5e-12 44.8 0.8 1.6e-11 44.0 0.8 1.5 1 0 0 1 1 1 1 TFIIS helical bundle-like domain ubiquitin PF00240.21 MSTRG.23261.2_3 - 1.9e-16 59.4 0.8 3.4e-16 58.6 0.8 1.4 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.29 MSTRG.23261.2_3 - 2.5e-06 27.1 3.2 4.1e-06 26.4 0.4 2.7 2 0 0 2 2 2 1 UBA/TS-N domain Rad60-SLD PF11976.6 MSTRG.23261.2_3 - 5.5e-05 22.8 0.9 9.5e-05 22.0 0.9 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.8 MSTRG.23261.2_3 - 0.0083 16.7 0.0 0.024 15.2 0.0 1.9 2 0 0 2 2 2 1 WXG100 protein secretion system (Wss), protein YukD DUF2407 PF10302.7 MSTRG.23261.2_3 - 0.055 13.9 0.0 0.14 12.6 0.0 1.7 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Symplekin_C PF12295.6 MSTRG.23261.2_3 - 0.061 13.3 0.1 0.061 13.3 0.1 2.9 3 0 0 3 3 3 0 Symplekin tight junction protein C terminal Rad60-SLD_2 PF13881.4 MSTRG.23261.2_3 - 0.066 13.2 0.1 0.15 12.1 0.1 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like HOIP-UBA PF16678.3 MSTRG.23261.2_3 - 0.081 12.8 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase Arm_2 PF04826.11 MSTRG.23261.2_3 - 0.14 11.4 6.6 0.1 11.9 0.5 2.4 2 1 0 2 2 2 0 Armadillo-like CUE PF02845.14 MSTRG.23261.2_3 - 0.24 11.0 0.0 0.24 11.0 0.0 2.7 3 0 0 3 3 3 0 CUE domain TraB PF01963.15 MSTRG.23722.1_2 - 4e-23 82.5 0.0 4.5e-23 82.4 0.0 1.0 1 0 0 1 1 1 1 TraB family Ion_trans PF00520.29 MSTRG.23010.1_2 - 6.2e-104 346.4 32.2 1.9e-67 226.9 10.0 2.1 2 0 0 2 2 2 2 Ion transport protein PKD_channel PF08016.10 MSTRG.23010.1_2 - 0.51 8.8 37.7 0.013 14.1 1.2 4.8 4 1 0 4 4 4 0 Polycystin cation channel HA2 PF04408.21 MSTRG.11526.2_3 - 3.1e-24 85.2 0.1 3.1e-24 85.2 0.1 2.0 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.29 MSTRG.11526.2_3 - 9.4e-13 48.4 0.0 1.7e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.27 MSTRG.11526.2_3 - 1.5e-07 31.2 0.2 4.2e-07 29.8 0.1 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_19 PF13245.4 MSTRG.11526.2_3 - 9.7e-05 22.6 0.1 0.00019 21.7 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.4 MSTRG.11526.2_3 - 0.00051 20.2 0.5 0.0048 17.0 0.5 2.3 1 1 0 1 1 1 1 AAA domain ResIII PF04851.13 MSTRG.11526.2_3 - 0.0022 17.9 0.0 0.8 9.6 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SRP54 PF00448.20 MSTRG.11526.2_3 - 0.0023 17.5 0.2 0.0095 15.4 0.0 2.1 2 1 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_30 PF13604.4 MSTRG.11526.2_3 - 0.0032 17.1 0.1 0.0058 16.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.12 MSTRG.11526.2_3 - 0.0055 16.6 0.1 0.0098 15.7 0.1 1.4 1 0 0 1 1 1 1 Flavivirus DEAD domain DUF1777 PF08648.10 MSTRG.11526.2_3 - 0.012 15.7 16.4 0.02 15.0 16.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) AAA_25 PF13481.4 MSTRG.11526.2_3 - 0.014 14.9 0.0 0.03 13.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.15 MSTRG.11526.2_3 - 0.031 13.9 0.1 2.1 8.0 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein Atrophin-1 PF03154.13 MSTRG.11526.2_3 - 0.032 12.4 2.3 0.046 11.9 2.3 1.1 1 0 0 1 1 1 0 Atrophin-1 family AAA_29 PF13555.4 MSTRG.11526.2_3 - 0.032 13.8 0.0 0.067 12.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSE PF00437.18 MSTRG.11526.2_3 - 0.057 12.3 0.0 0.14 11.0 0.0 1.7 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF3915 PF13054.4 MSTRG.11526.2_3 - 0.085 12.7 5.5 0.19 11.6 5.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Septin PF00735.16 MSTRG.22912.3_1 - 2.4e-97 325.4 0.8 3.6e-97 324.8 0.8 1.3 1 0 0 1 1 1 1 Septin AAA_22 PF13401.4 MSTRG.22912.3_1 - 0.0018 18.4 0.0 0.005 17.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 MSTRG.22912.3_1 - 0.0041 17.4 0.4 0.019 15.2 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain Roc PF08477.11 MSTRG.22912.3_1 - 0.005 16.9 0.1 0.017 15.2 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.21 MSTRG.22912.3_1 - 0.0056 16.6 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 MSTRG.22912.3_1 - 0.0071 15.8 1.2 1.9 7.8 0.0 2.6 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 MSTRG.22912.3_1 - 0.0078 16.0 0.0 0.47 10.2 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 DUF3080 PF11279.6 MSTRG.22912.3_1 - 0.019 14.0 4.5 0.029 13.4 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3080) AAA_29 PF13555.4 MSTRG.22912.3_1 - 0.022 14.3 0.1 0.044 13.4 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AIG1 PF04548.14 MSTRG.22912.3_1 - 0.04 13.1 0.0 0.077 12.2 0.0 1.5 1 0 0 1 1 1 0 AIG1 family Tospo_nucleocap PF01533.14 MSTRG.22912.3_1 - 0.051 12.9 0.0 0.089 12.1 0.0 1.3 1 0 0 1 1 1 0 Tospovirus nucleocapsid protein Atg14 PF10186.7 MSTRG.22912.3_1 - 0.28 10.1 10.1 0.45 9.4 10.1 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Exonuc_VII_L PF02601.13 MSTRG.22912.3_1 - 2 7.8 7.8 4.1 6.7 7.8 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit AAA_23 PF13476.4 MSTRG.22912.3_1 - 2.1 8.7 13.9 4.9 7.5 0.6 2.4 2 1 0 2 2 2 0 AAA domain DUF3552 PF12072.6 MSTRG.22912.3_1 - 7.7 5.7 18.1 13 5.0 18.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Bcl-2 PF00452.17 MSTRG.25542.1_1 - 9.6e-23 80.5 1.3 1.9e-22 79.6 1.3 1.5 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family Gly_acyl_tr_N PF06021.9 MSTRG.7766.1_1 - 2.9e-27 96.0 5.9 2.3e-16 60.4 0.3 3.1 3 0 0 3 3 3 2 Aralkyl acyl-CoA:amino acid N-acyltransferase FR47 PF08445.8 MSTRG.7766.1_1 - 5.7e-15 54.9 0.0 1e-14 54.1 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Gly_acyl_tr_C PF08444.8 MSTRG.7766.1_1 - 1.6e-13 50.5 0.0 3e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region Acetyltransf_1 PF00583.23 MSTRG.7766.1_1 - 7.9e-08 32.4 0.0 1.2e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.5 MSTRG.7766.1_1 - 0.00044 20.5 0.0 0.0008 19.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.5 MSTRG.7766.1_1 - 0.0011 18.8 0.0 0.0018 18.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain TMPIT PF07851.11 MSTRG.8684.1_1 - 6.8e-18 64.8 1.5 1.1e-17 64.1 1.5 1.3 1 0 0 1 1 1 1 TMPIT-like protein OSTbeta PF15048.4 MSTRG.8684.1_1 - 0.064 13.2 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein HAT_KAT11 PF08214.9 MSTRG.6454.3_3 - 2.8e-69 233.9 0.3 2.8e-69 233.9 0.3 2.6 2 0 0 2 2 2 1 Histone acetylation protein KIX PF02172.14 MSTRG.6454.3_3 - 2.7e-39 133.1 1.5 2.7e-39 133.1 1.5 1.8 2 0 0 2 2 2 1 KIX domain Creb_binding PF09030.8 MSTRG.6454.3_3 - 1.2e-30 106.3 36.0 1.2e-30 106.3 36.0 14.5 8 2 5 14 14 14 1 Creb binding zf-TAZ PF02135.14 MSTRG.6454.3_3 - 1.5e-28 98.9 73.4 5e-19 68.4 21.2 4.1 3 0 0 3 3 3 2 TAZ zinc finger DUF902 PF06001.11 MSTRG.6454.3_3 - 1.2e-20 73.5 7.2 1.2e-20 73.5 7.2 2.5 2 0 0 2 2 2 1 Domain of Unknown Function (DUF902) Bromodomain PF00439.23 MSTRG.6454.3_3 - 4.4e-15 55.4 0.1 1.1e-14 54.1 0.1 1.7 1 0 0 1 1 1 1 Bromodomain ZZ PF00569.15 MSTRG.6454.3_3 - 6.7e-14 51.3 13.2 6.7e-14 51.3 13.2 3.2 3 0 0 3 3 3 1 Zinc finger, ZZ type Npa1 PF11707.6 MSTRG.6454.3_3 - 0.004 16.5 0.0 0.0068 15.7 0.0 1.3 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal ArfGap PF01412.16 MSTRG.15244.3_1 - 3.2e-28 98.0 0.1 8.3e-28 96.6 0.1 1.7 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Cep57_CLD PF14073.4 MSTRG.18045.1_3 - 3.7e-53 180.1 20.2 3.7e-53 180.1 20.2 2.3 2 0 0 2 2 2 1 Centrosome localisation domain of Cep57 Cep57_MT_bd PF06657.11 MSTRG.18045.1_3 - 4.9e-14 52.4 8.3 4.9e-14 52.4 8.3 2.7 3 0 0 3 3 3 1 Centrosome microtubule-binding domain of Cep57 CTNNB1_binding PF08347.9 MSTRG.4916.1_3 - 3.4e-100 334.2 3.0 3.4e-100 334.2 3.0 2.5 2 1 0 2 2 2 1 N-terminal CTNNB1 binding HMG_box PF00505.17 MSTRG.4916.1_3 - 5.2e-22 77.9 1.0 1.2e-21 76.7 1.0 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 MSTRG.4916.1_3 - 1.2e-07 32.1 0.8 1.2e-07 32.1 0.8 1.8 2 0 0 2 2 2 1 HMG-box domain RRT14 PF17075.3 MSTRG.4916.1_3 - 8 6.4 14.9 2.8 7.9 6.0 2.3 2 0 0 2 2 2 0 Regular of rDNA transcription protein 14 UDPGP PF01704.16 MSTRG.23657.1_1 - 2e-85 286.8 0.0 2.7e-85 286.4 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.5 MSTRG.23657.1_1 - 0.042 14.0 0.0 0.076 13.2 0.0 1.4 1 0 0 1 1 1 0 MobA-like NTP transferase domain DUF4749 PF15936.3 MSTRG.14727.1_1 - 3e-27 95.5 1.0 5.8e-27 94.6 1.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) PDZ PF00595.22 MSTRG.14727.1_1 - 2e-17 63.2 0.0 3.1e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) LIM PF00412.20 MSTRG.14727.1_1 - 5.5e-09 36.0 5.1 5.5e-09 36.0 5.1 2.0 2 0 0 2 2 2 1 LIM domain PDZ_2 PF13180.4 MSTRG.14727.1_1 - 5.5e-05 23.3 0.0 9.7e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 PDZ domain Pkinase PF00069.23 MSTRG.17597.2_3 - 3.3e-25 88.8 0.0 4.9e-25 88.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain CK1gamma_C PF12605.6 MSTRG.17597.2_3 - 1.3e-13 51.8 5.2 2.8e-08 34.7 0.4 2.6 1 1 1 2 2 2 2 Casein kinase 1 gamma C terminal Pkinase_Tyr PF07714.15 MSTRG.17597.2_3 - 1.7e-12 47.0 0.0 2.5e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RHD_dimer PF16179.3 MSTRG.9981.1_2 - 1.1e-21 76.6 0.1 1.6e-21 76.1 0.1 1.2 1 0 0 1 1 1 1 Rel homology dimerisation domain TIG PF01833.22 MSTRG.9981.1_2 - 4.4e-08 32.9 0.0 1.3e-07 31.5 0.0 1.8 2 0 0 2 2 2 1 IPT/TIG domain Med12-LCEWAV PF12145.6 MSTRG.7271.3_2 - 2.9e-132 441.7 0.5 2.9e-132 441.7 0.5 2.9 2 0 0 2 2 2 1 Eukaryotic Mediator 12 subunit domain Med12-PQL PF12144.6 MSTRG.7271.3_2 - 1.3e-85 286.4 43.8 1.3e-85 286.4 43.8 5.4 4 1 1 5 5 5 1 Eukaryotic Mediator 12 catenin-binding domain Med12-LCEWAV PF12145.6 MSTRG.7271.3_3 - 4.1e-42 144.5 0.0 4.1e-42 144.5 0.0 2.6 2 1 1 3 3 3 1 Eukaryotic Mediator 12 subunit domain Med12 PF09497.8 MSTRG.7271.3_3 - 2.1e-13 50.2 0.1 4.3e-13 49.2 0.1 1.5 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 RRM_1 PF00076.20 MSTRG.7245.1_1 - 2.1e-17 62.5 0.0 2.9e-17 62.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 MSTRG.7245.1_1 - 0.0005 19.8 0.0 0.00081 19.2 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.3 MSTRG.7245.1_1 - 0.00079 19.1 0.0 0.0012 18.5 0.0 1.1 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_7 PF16367.3 MSTRG.7245.1_1 - 0.0068 16.4 0.0 0.013 15.5 0.0 1.5 2 0 0 2 2 2 1 RNA recognition motif LBP_BPI_CETP PF01273.23 MSTRG.12326.1_2 - 2.3e-24 85.8 0.4 5.9e-24 84.4 0.1 1.7 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain LBP_BPI_CETP_C PF02886.15 MSTRG.12326.1_2 - 3.7e-17 62.4 0.1 8.7e-17 61.2 0.1 1.6 2 0 0 2 2 2 1 LBP / BPI / CETP family, C-terminal domain Fibrinogen_C PF00147.16 MSTRG.9260.1_1 - 6.4e-82 274.5 3.3 9.5e-82 273.9 3.3 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain fn3 PF00041.19 MSTRG.9260.1_1 - 2e-07 31.1 0.1 1.9e-06 28.0 0.0 2.4 2 0 0 2 2 2 1 Fibronectin type III domain zf-H2C2_2 PF13465.4 MSTRG.14119.2_2 - 6e-20 70.6 11.5 5e-06 26.6 2.3 4.5 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.14119.2_2 - 3.2e-07 30.3 44.7 0.001 19.2 2.5 5.7 6 0 0 6 6 6 4 Zinc finger, C2H2 type zf-met PF12874.5 MSTRG.14119.2_2 - 8.1 6.8 13.0 3.7 7.9 0.6 4.4 4 0 0 4 4 4 0 Zinc-finger of C2H2 type RRM_1 PF00076.20 MSTRG.11182.1_2 - 1.7e-21 75.7 0.0 9.4e-08 31.6 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Methyltransf_19 PF04672.10 MSTRG.11182.1_2 - 0.099 12.0 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl methyltransferase DREPP PF05558.10 MSTRG.11182.1_2 - 0.1 12.3 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide Cys_rich_FGFR PF00839.15 MSTRG.5890.5_2 - 1.1e-128 419.2 82.6 2.3e-16 59.5 1.2 10.4 11 0 0 11 11 11 10 Cysteine rich repeat PP2C_C PF07830.11 MSTRG.5890.5_2 - 2.6 8.4 6.8 1.9 8.8 0.4 3.9 4 0 0 4 4 4 0 Protein serine/threonine phosphatase 2C, C-terminal domain Bromodomain PF00439.23 MSTRG.21480.2_1 - 4.8e-19 68.1 0.3 1.1e-18 67.0 0.3 1.6 1 0 0 1 1 1 1 Bromodomain IMUP PF15761.3 MSTRG.21480.2_1 - 0.00021 21.8 1.9 0.00063 20.3 1.9 1.8 1 0 0 1 1 1 1 Immortalisation up-regulated protein FlxA PF14282.4 MSTRG.21480.2_1 - 0.0066 16.3 8.6 0.013 15.3 8.6 1.4 1 0 0 1 1 1 1 FlxA-like protein IncA PF04156.12 MSTRG.21480.2_1 - 0.021 14.5 2.1 0.031 14.0 2.1 1.3 1 0 0 1 1 1 0 IncA protein FadA PF09403.8 MSTRG.21480.2_1 - 0.099 13.0 5.3 0.39 11.1 5.3 2.0 1 0 0 1 1 1 0 Adhesion protein FadA ACTH_assoc PF16102.3 MSTRG.21480.2_1 - 0.1 13.3 1.0 0.19 12.5 1.0 1.4 1 0 0 1 1 1 0 ACTH-associated domain DUF342 PF03961.11 MSTRG.21480.2_1 - 0.41 9.1 5.5 0.58 8.6 5.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF2096 PF09869.7 MSTRG.21480.2_1 - 0.9 9.5 4.4 1.1 9.2 2.3 2.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2096) PAP2 PF01569.19 MSTRG.1910.2_3 - 1.2e-22 80.0 0.3 2.7e-22 78.9 0.3 1.5 1 0 0 1 1 1 1 PAP2 superfamily VWA PF00092.26 MSTRG.24405.1_1 - 1.1e-94 315.5 1.2 1.1e-46 159.2 0.0 3.1 3 0 0 3 3 3 2 von Willebrand factor type A domain VWA_2 PF13519.4 MSTRG.24405.1_1 - 9.6e-33 112.9 0.0 2e-15 57.2 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_3 PF13768.4 MSTRG.24405.1_1 - 3.6e-08 33.3 0.0 0.0052 16.6 0.0 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain DUF2278 PF10042.7 MSTRG.24405.1_1 - 0.0055 16.6 0.0 2.8 7.8 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2278) FimA PF16970.3 MSTRG.24405.1_1 - 0.0093 16.3 0.6 0.63 10.3 0.1 2.5 2 0 0 2 2 2 1 Type-1 fimbrial protein, A RasGAP PF00616.17 MSTRG.24405.1_1 - 0.36 10.4 4.5 13 5.2 0.1 3.2 3 0 0 3 3 3 0 GTPase-activator protein for Ras-like GTPase DnaJ_C PF01556.16 MSTRG.6061.1_1 - 4.4e-32 111.1 0.1 6.4e-32 110.6 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.29 MSTRG.6061.1_1 - 4.2e-27 93.9 2.2 7.6e-27 93.1 2.2 1.4 1 0 0 1 1 1 1 DnaJ domain Kringle PF00051.16 MSTRG.15496.1_3 - 0.39 10.9 3.7 0.8 9.9 3.7 1.6 1 0 0 1 1 1 0 Kringle domain DDE_3 PF13358.4 MSTRG.15842.1_1 - 1.2e-08 34.7 0.0 1.8e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease TRP_2 PF08344.9 MSTRG.1666.1_2 - 2.8e-25 88.2 2.0 5.6e-25 87.2 2.0 1.6 1 0 0 1 1 1 1 Transient receptor ion channel II Ank_2 PF12796.5 MSTRG.1666.1_2 - 1.1e-06 29.0 2.8 0.00021 21.7 0.5 3.1 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.1666.1_2 - 2.6e-06 27.7 1.0 0.15 12.6 0.0 3.5 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.4 MSTRG.1666.1_2 - 0.0039 17.4 1.6 0.75 10.1 0.1 3.7 4 1 0 4 4 4 1 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.1666.1_2 - 0.051 13.9 1.5 5.6 7.5 0.1 3.4 3 0 0 3 3 3 0 Ankyrin repeat Ank_3 PF13606.4 MSTRG.1666.1_2 - 0.65 10.6 9.3 2.9 8.6 0.0 4.3 6 0 0 6 6 6 0 Ankyrin repeat Metallophos PF00149.26 MSTRG.8785.1_2 - 1.1e-38 133.7 0.1 1.8e-38 133.0 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.3 MSTRG.8785.1_2 - 1.1e-19 70.5 0.6 1.1e-19 70.5 0.6 1.8 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain zf-C5HC2 PF02928.14 MSTRG.3418.1_2 - 0.0076 16.4 5.7 0.024 14.9 5.7 1.8 1 0 0 1 1 1 1 C5HC2 zinc finger Sugar_tr PF00083.22 MSTRG.3418.1_3 - 3e-25 88.9 5.6 5.3e-25 88.0 5.6 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 MSTRG.3418.1_3 - 1.7e-16 60.0 14.5 4.9e-16 58.5 14.5 1.8 1 0 0 1 1 1 1 Major Facilitator Superfamily FANCAA PF15146.4 MSTRG.825.1_1 - 6.4e-41 140.7 1.7 6.4e-41 140.7 1.7 1.8 2 0 0 2 2 2 1 Fanconi anemia-associated PQQ_3 PF13570.4 MSTRG.825.1_1 - 0.0014 19.0 0.5 0.18 12.2 0.0 3.9 5 0 0 5 5 5 1 PQQ-like domain Tail_tube PF10618.7 MSTRG.825.1_1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Phage tail tube protein Choline_transpo PF04515.10 MSTRG.11567.4_2 - 1.7e-56 191.7 17.4 1.7e-56 191.7 17.4 3.0 2 1 0 3 3 3 2 Plasma-membrane choline transporter RRM_1 PF00076.20 MSTRG.10519.1_2 - 4e-15 55.3 0.1 6.1e-15 54.7 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 MSTRG.10519.1_2 - 0.044 13.7 0.1 0.068 13.1 0.1 1.2 1 0 0 1 1 1 0 RNA binding motif Pkinase_Tyr PF07714.15 MSTRG.7267.1_1 - 9.6e-90 300.2 0.0 1.5e-89 299.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.7267.1_1 - 2.4e-43 148.2 0.0 3.8e-43 147.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 MSTRG.7267.1_1 - 2.8e-22 78.4 0.0 6.3e-22 77.3 0.0 1.6 1 0 0 1 1 1 1 SH2 domain PH PF00169.27 MSTRG.7267.1_1 - 5.6e-17 62.0 0.4 1.2e-16 60.9 0.4 1.6 1 0 0 1 1 1 1 PH domain BTK PF00779.17 MSTRG.7267.1_1 - 3.8e-14 52.0 1.4 9.6e-14 50.8 1.4 1.8 1 0 0 1 1 1 1 BTK motif SH3_1 PF00018.26 MSTRG.7267.1_1 - 1.2e-12 47.1 0.1 2.9e-12 45.8 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.7267.1_1 - 6.4e-06 25.6 0.0 1.6e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 MSTRG.7267.1_1 - 2.2e-05 24.1 0.0 4.7e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Kinase-like PF14531.4 MSTRG.7267.1_1 - 0.007 15.6 0.0 0.013 14.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like PH_11 PF15413.4 MSTRG.7267.1_1 - 0.0072 16.6 0.5 0.019 15.2 0.5 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.4 MSTRG.7267.1_1 - 0.012 15.6 1.2 0.037 14.0 1.2 1.8 1 1 0 1 1 1 0 PH domain APH PF01636.21 MSTRG.7267.1_1 - 0.013 15.3 0.0 0.022 14.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family SH3_3 PF08239.9 MSTRG.7267.1_1 - 0.045 13.9 0.4 0.087 13.0 0.4 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain TFIIA PF03153.11 MSTRG.25684.1_3 - 3.2e-88 297.4 76.1 2.2e-51 176.1 25.4 2.1 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit Glu_synthase PF01645.15 MSTRG.25684.1_3 - 0.022 13.8 0.8 0.031 13.3 0.8 1.2 1 0 0 1 1 1 0 Conserved region in glutamate synthase NOA36 PF06524.10 MSTRG.25684.1_3 - 0.54 9.4 4.6 0.94 8.7 4.6 1.3 1 0 0 1 1 1 0 NOA36 protein 3HCDH PF00725.20 MSTRG.19985.1_2 - 3.8e-26 91.4 0.0 2e-18 66.7 0.0 2.1 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain FTCD_N PF07837.10 MSTRG.737.1_3 - 3.1e-48 163.8 0.0 4.1e-48 163.4 0.0 1.2 1 0 0 1 1 1 1 Formiminotransferase domain, N-terminal subdomain Methyltrn_RNA_2 PF04013.10 MSTRG.737.1_3 - 0.16 11.5 0.1 0.26 10.8 0.1 1.2 1 0 0 1 1 1 0 Putative SAM-dependent RNA methyltransferase fn3 PF00041.19 MSTRG.244.2_2 - 0 5359.0 229.1 3e-17 62.6 0.0 121.7 121 1 0 121 121 121 120 Fibronectin type III domain I-set PF07679.14 MSTRG.244.2_2 - 0 1919.9 39.8 8.1e-16 57.7 0.0 52.1 54 0 0 54 54 49 44 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.244.2_2 - 0 1128.9 0.2 2.2e-08 34.5 0.0 48.1 46 0 0 46 46 44 43 Immunoglobulin domain Pur_ac_phosph_N PF16656.3 MSTRG.244.2_2 - 2.7e-139 454.0 177.8 0.081 13.4 0.1 94.6 103 5 0 103 103 91 23 Purple acid Phosphatase, N-terminal domain ig PF00047.23 MSTRG.244.2_2 - 8.6e-138 448.8 8.1 1.1e-05 25.4 0.0 40.9 42 0 0 42 42 40 25 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.244.2_2 - 1.8e-129 422.2 0.0 0.00039 20.6 0.0 43.5 44 0 0 44 44 43 25 Immunoglobulin domain fn3_2 PF16893.3 MSTRG.244.2_2 - 4.3e-86 283.1 0.0 0.13 12.3 0.0 58.8 69 0 0 69 69 62 9 Fibronectin type III domain Tissue_fac PF01108.15 MSTRG.244.2_2 - 2.9e-38 129.8 74.9 2.2 8.0 0.0 48.3 59 0 0 59 59 50 3 Tissue factor fn3_4 PF16794.3 MSTRG.244.2_2 - 4.4e-34 116.3 0.0 1.7 8.4 0.0 37.2 46 0 0 46 46 35 1 Fibronectin-III type domain V-set PF07686.15 MSTRG.244.2_2 - 4.5e-34 116.7 17.0 0.67 10.0 0.1 30.9 35 2 0 35 35 31 3 Immunoglobulin V-set domain Receptor_2B4 PF11465.6 MSTRG.244.2_2 - 1.1e-32 112.3 13.3 0.54 10.3 0.0 29.4 35 0 0 35 35 29 4 Natural killer cell receptor 2B4 DUF2369 PF10179.7 MSTRG.244.2_2 - 9e-30 102.9 0.0 4.6 7.7 0.0 30.9 38 0 0 38 38 27 1 Uncharacterised conserved protein (DUF2369) C2-set_2 PF08205.10 MSTRG.244.2_2 - 3e-29 100.8 41.4 3.3 7.7 0.0 32.1 39 0 0 39 39 33 2 CD80-like C2-set immunoglobulin domain SusE PF14292.4 MSTRG.244.2_2 - 3e-20 72.6 64.8 0.69 10.2 0.0 36.4 42 2 2 44 44 32 1 SusE outer membrane protein Y_Y_Y PF07495.11 MSTRG.244.2_2 - 1.4e-13 50.4 37.8 19 5.2 0.0 29.0 33 0 0 33 33 27 0 Y_Y_Y domain DUF11 PF01345.16 MSTRG.244.2_2 - 9.1e-09 35.4 72.9 3 8.1 0.1 24.5 24 0 0 24 24 21 3 Domain of unknown function DUF11 Cadherin PF00028.15 MSTRG.244.2_2 - 3.5e-05 24.0 0.9 6.8 7.1 0.0 11.4 12 0 0 12 12 3 0 Cadherin domain CRISPR_assoc PF08798.9 MSTRG.244.2_2 - 0.00038 20.5 0.5 2.6e+02 1.4 0.0 10.6 11 0 0 11 11 7 0 CRISPR associated protein DUF4493 PF14900.4 MSTRG.244.2_2 - 0.00075 19.5 5.2 9.1 6.1 0.0 9.1 8 0 0 8 8 7 0 Domain of unknown function (DUF4493) RL11D PF11088.6 MSTRG.244.2_2 - 0.0099 16.0 25.3 14 5.9 0.0 12.1 14 0 0 14 14 9 0 Glycoprotein encoding membrane proteins RL5A and RL6 CDKN3 PF05706.10 MSTRG.244.2_2 - 0.025 14.1 0.0 6.8 6.2 0.0 5.4 6 0 0 6 6 4 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Collagen_bind_2 PF12904.5 MSTRG.244.2_2 - 0.032 14.1 0.1 60 3.6 0.0 7.2 5 0 0 5 5 3 0 Putative collagen-binding domain of a collagenase Aida_C2 PF14186.4 MSTRG.244.2_2 - 0.044 13.3 0.6 84 2.6 0.0 5.0 5 0 0 5 5 5 0 Cytoskeletal adhesion Haem_degrading PF03928.12 MSTRG.244.2_2 - 0.095 12.6 0.0 1.5e+02 2.3 0.0 5.1 6 0 0 6 6 3 0 Haem-degrading DUF4402 PF14352.4 MSTRG.244.2_2 - 0.68 10.5 19.9 2.8 8.5 2.1 6.7 6 0 0 6 6 5 0 Domain of unknown function (DUF4402) Kelch_1 PF01344.23 MSTRG.244.2_2 - 0.73 9.3 3.0 0.78 9.2 0.4 2.4 2 0 0 2 2 2 0 Kelch motif DUF4910 PF16254.3 MSTRG.244.2_2 - 0.79 8.4 5.0 58 2.3 0.0 6.5 7 0 0 7 7 7 0 Domain of unknown function (DUF4910) DKCLD PF08068.10 MSTRG.244.2_2 - 7.5 6.6 5.9 8 6.5 0.1 3.9 4 0 0 4 4 3 0 DKCLD (NUC011) domain V-set PF07686.15 MSTRG.18068.1_3 - 0.14 12.2 0.2 0.31 11.1 0.1 1.6 2 0 0 2 2 2 0 Immunoglobulin V-set domain 7tm_1 PF00001.19 MSTRG.12333.3_3 - 1.3e-38 132.7 4.5 1.9e-38 132.1 4.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 MSTRG.12333.3_3 - 2e-07 30.9 10.2 2.8e-07 30.4 10.2 1.1 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 MSTRG.12333.3_3 - 2.8e-06 26.7 8.7 4.8e-06 26.0 8.7 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.7 MSTRG.12333.3_3 - 0.0021 17.3 13.9 0.0037 16.6 13.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 MSTRG.12333.3_3 - 0.013 14.7 13.7 0.022 14.0 13.6 1.4 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv Ank_2 PF12796.5 MSTRG.12803.1_2 - 6e-58 193.3 21.4 5.1e-13 49.3 1.3 4.3 1 1 6 7 7 7 6 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.12803.1_2 - 3.9e-26 90.6 7.0 5.8e-09 35.9 0.2 5.9 3 1 3 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.12803.1_2 - 4.2e-26 90.1 9.7 0.0001 22.5 0.2 7.6 7 0 0 7 7 7 6 Ankyrin repeat Ank_4 PF13637.4 MSTRG.12803.1_2 - 3e-24 84.9 7.2 9.7e-07 29.1 0.1 7.7 4 2 3 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.12803.1_2 - 8.4e-24 80.9 5.4 0.0007 19.7 0.1 7.7 8 0 0 8 8 8 5 Ankyrin repeat SOCS_box PF07525.14 MSTRG.12803.1_2 - 6.8e-09 35.8 4.3 2.5e-08 34.0 4.3 2.1 1 0 0 1 1 1 1 SOCS box NPIP PF06409.9 MSTRG.14374.2_1 - 1.2e-05 24.5 15.4 0.0016 17.6 7.8 3.5 2 1 1 3 3 3 2 Nuclear pore complex interacting protein (NPIP) ERM PF00769.17 MSTRG.14374.2_1 - 0.0014 18.4 21.1 0.0014 18.4 21.1 5.7 2 1 2 5 5 5 2 Ezrin/radixin/moesin family Inhibitor_I9 PF05922.14 MSTRG.11885.1_2 - 0.49 10.9 2.3 1 9.9 2.3 1.4 1 0 0 1 1 1 0 Peptidase inhibitor I9 OLF PF02191.14 MSTRG.11885.1_3 - 3.2e-85 285.5 3.6 4.9e-85 284.9 3.6 1.3 1 0 0 1 1 1 1 Olfactomedin-like domain HRM PF02793.20 MSTRG.11885.1_3 - 7.4e-07 29.2 1.3 7.4e-07 29.2 1.3 1.8 2 0 0 2 2 2 1 Hormone receptor domain GAIN PF16489.3 MSTRG.11885.1_3 - 1.8e-05 24.2 0.1 3.2e-05 23.3 0.1 1.4 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Mucin PF01456.15 MSTRG.11885.1_3 - 0.0017 18.2 20.0 0.0035 17.2 20.0 1.4 1 0 0 1 1 1 1 Mucin-like glycoprotein Lamp PF01299.15 MSTRG.11885.1_3 - 6.8 6.0 11.4 12 5.2 11.4 1.3 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) Fam20C PF06702.10 MSTRG.14210.1_2 - 1.8e-38 132.4 0.9 2.7e-38 131.8 0.9 1.2 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.4 MSTRG.14210.1_2 - 0.0033 16.3 0.1 0.0043 15.9 0.1 1.1 1 0 0 1 1 1 1 FAM198 protein Peptidase_C48 PF02902.17 MSTRG.12102.2_2 - 1.4e-36 126.3 1.7 2.1e-36 125.7 1.7 1.2 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain La PF05383.15 MSTRG.1085.1_2 - 8.5e-08 32.0 0.0 1.5e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 La domain Cyt-b5 PF00173.26 MSTRG.1037.1_2 - 1.4e-08 34.7 0.0 2e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain SLC12 PF03522.13 MSTRG.12316.2_3 - 4.7e-128 427.6 0.1 4.3e-79 266.3 0.0 2.0 1 1 1 2 2 2 2 Solute carrier family 12 zf-C2H2 PF00096.24 MSTRG.25877.2_2 - 1.5e-11 44.0 58.5 0.0022 18.2 7.3 8.8 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.25877.2_2 - 1.2e-08 34.9 32.2 0.0047 17.2 0.1 7.5 8 0 0 8 8 8 4 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.25877.2_2 - 3.6e-08 33.4 66.2 0.047 14.4 5.7 9.2 9 0 0 9 9 9 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.25877.2_2 - 0.00019 21.5 29.5 1.1 9.6 0.7 7.4 7 0 0 7 7 7 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 MSTRG.25877.2_2 - 0.37 11.0 19.2 10 6.4 0.2 5.4 4 2 1 5 5 5 0 C2H2 type zinc-finger (2 copies) Clat_adaptor_s PF01217.18 MSTRG.23069.6_3 - 3.6e-42 143.5 0.6 4.6e-42 143.2 0.6 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain GTP_EFTU PF00009.25 MSTRG.10886.1_2 - 3.8e-44 150.4 0.0 5.5e-44 149.9 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.3 MSTRG.10886.1_2 - 9.8e-39 132.6 11.1 1.7e-38 131.9 11.1 1.4 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.16 MSTRG.10886.1_2 - 2.4e-25 88.5 0.0 5.1e-25 87.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.22 MSTRG.10886.1_2 - 6.2e-23 80.5 0.0 1.3e-22 79.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.23 MSTRG.10886.1_2 - 1.4e-12 47.7 0.0 2.8e-12 46.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.4 MSTRG.10886.1_2 - 3e-08 33.5 0.0 7.7e-08 32.2 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II Ras PF00071.20 MSTRG.10886.1_2 - 0.023 14.2 0.0 0.1 12.1 0.0 2.0 1 1 0 1 1 1 0 Ras family RVT_1 PF00078.25 MSTRG.12388.1_2 - 3.2e-33 115.0 0.0 4.7e-33 114.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Beach PF02138.16 MSTRG.10098.2_2 - 1e-36 126.7 0.0 1.8e-36 125.8 0.0 1.4 1 0 0 1 1 1 1 Beige/BEACH domain Pkinase PF00069.23 MSTRG.10098.2_2 - 0.026 13.7 0.0 0.057 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein kinase domain DUF4193 PF13834.4 MSTRG.10098.2_2 - 2.6 8.5 5.3 1.3 9.4 1.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4193) DMAP_binding PF06464.9 MSTRG.10461.1_3 - 3.2e-32 111.5 1.3 8.5e-31 106.9 0.0 2.4 2 0 0 2 2 2 1 DMAP1-binding Domain AMP-binding PF00501.26 MSTRG.10461.1_3 - 1.4e-11 43.5 0.0 2.3e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme GvpG PF05120.10 MSTRG.10461.1_3 - 0.0037 17.1 0.0 0.0086 15.9 0.0 1.6 1 0 0 1 1 1 1 Gas vesicle protein G SR-25 PF10500.7 MSTRG.10461.1_3 - 0.69 9.4 8.1 0.15 11.6 4.6 1.5 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Vps5 PF09325.8 MSTRG.5029.1_1 - 1.1e-78 263.9 18.8 1.5e-78 263.5 18.8 1.2 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.22 MSTRG.5029.1_1 - 7.5e-25 87.0 0.0 7.1e-24 83.8 0.0 2.3 2 0 0 2 2 2 1 PX domain Sorting_nexin PF03700.11 MSTRG.5029.1_1 - 4.2e-11 43.4 5.4 9e-11 42.3 5.1 1.7 1 1 0 1 1 1 1 Sorting nexin, N-terminal domain BAR_3_WASP_bdg PF10456.7 MSTRG.5029.1_1 - 0.00036 19.9 5.8 0.014 14.7 4.3 2.7 2 1 0 2 2 2 1 WASP-binding domain of Sorting nexin protein FAM92 PF06730.9 MSTRG.5029.1_1 - 0.44 9.8 7.9 0.76 9.0 7.9 1.3 1 0 0 1 1 1 0 FAM92 protein LSR PF05624.12 MSTRG.22309.1_3 - 1.7e-19 69.4 41.7 1.7e-19 69.4 41.7 2.2 2 0 0 2 2 2 1 Lipolysis stimulated receptor (LSR) V-set PF07686.15 MSTRG.22309.1_3 - 5.5e-07 29.6 0.1 0.00067 19.6 0.0 2.5 1 1 1 2 2 2 2 Immunoglobulin V-set domain Syja_N PF02383.16 MSTRG.877.1_1 - 5.5e-67 226.1 0.1 8.8e-67 225.5 0.1 1.3 1 0 0 1 1 1 1 SacI homology domain RhoGAP PF00620.25 MSTRG.23678.7_2 - 2.2e-49 167.1 0.0 5.2e-49 165.8 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.20 MSTRG.23678.7_2 - 2.8e-06 27.0 9.0 2.8e-06 27.0 9.0 2.1 3 0 0 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) FCH PF00611.21 MSTRG.23678.7_2 - 0.0001 22.4 0.4 0.00038 20.5 0.4 2.0 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain Adap_comp_sub PF00928.19 MSTRG.7647.3_1 - 3.6e-73 246.1 0.0 4.9e-73 245.6 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.18 MSTRG.7647.3_1 - 1.9e-06 27.7 0.1 3.4e-06 26.9 0.1 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain IPK PF03770.14 MSTRG.14027.1_3 - 2.2e-64 216.8 0.0 3.3e-64 216.2 0.0 1.3 1 0 0 1 1 1 1 Inositol polyphosphate kinase Mit_proteolip PF08039.9 MSTRG.25089.1_1 - 3.9 7.7 8.8 8.6 6.6 8.8 1.6 1 0 0 1 1 1 0 Mitochondrial proteolipid WD40 PF00400.30 MSTRG.8640.1_1 - 2.5e-13 50.1 9.9 0.0034 18.1 0.0 6.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.8640.1_1 - 9.1e-07 29.0 0.0 1.2 9.3 0.0 5.1 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Neural_ProG_Cyt PF06567.9 MSTRG.8640.1_1 - 0.084 13.0 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Neural chondroitin sulphate proteoglycan cytoplasmic domain G-gamma PF00631.20 MSTRG.2750.2_1 - 6.3e-18 64.4 0.0 7.6e-18 64.2 0.0 1.1 1 0 0 1 1 1 1 GGL domain HPTransfase PF10090.7 MSTRG.28380.1_1 - 0.064 12.7 0.1 0.077 12.4 0.1 1.1 1 0 0 1 1 1 0 Histidine phosphotransferase DUF329 PF03884.12 MSTRG.14026.1_2 - 0.038 13.6 0.0 0.054 13.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF329) bZIP_1 PF00170.19 MSTRG.14088.2_3 - 7e-20 70.8 9.4 1.2e-19 70.0 9.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor pKID PF02173.15 MSTRG.14088.2_3 - 8.5e-17 60.2 0.6 1.7e-16 59.3 0.6 1.5 1 0 0 1 1 1 1 pKID domain bZIP_2 PF07716.13 MSTRG.14088.2_3 - 6e-08 32.5 9.1 9.3e-08 31.9 9.1 1.2 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 MSTRG.14088.2_3 - 0.0056 17.0 4.5 0.011 16.1 4.5 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor ASD2 PF08687.9 MSTRG.14088.2_3 - 0.032 13.7 0.4 0.032 13.7 0.4 1.5 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Pacs-1 PF10254.7 MSTRG.14778.1_2 - 6.7e-194 644.4 0.0 6.7e-194 644.4 0.0 1.6 2 0 0 2 2 2 1 PACS-1 cytosolic sorting protein zf-TAZ PF02135.14 MSTRG.24116.3_2 - 3.2e-14 53.0 16.2 4.6e-14 52.5 16.2 1.2 1 0 0 1 1 1 1 TAZ zinc finger PDZ PF00595.22 MSTRG.1028.1_1 - 2.4e-65 216.8 8.6 5.2e-21 74.7 0.1 3.2 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.1028.1_1 - 3.1e-19 68.9 2.1 2.5e-06 27.6 0.0 3.3 3 0 0 3 3 3 3 PDZ domain PDZ_assoc PF10600.7 MSTRG.1028.1_1 - 1.6e-14 54.3 10.4 3.5e-14 53.2 10.4 1.6 1 0 0 1 1 1 1 PDZ-associated domain of NMDA receptors p450 PF00067.20 MSTRG.20165.1_3 - 3e-116 388.8 0.0 3.9e-116 388.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3585 PF12130.6 MSTRG.22183.1_1 - 1.8e-47 160.8 17.0 1.8e-47 160.8 17.0 2.1 2 0 0 2 2 1 1 Protein of unknown function (DUF3585) CH PF00307.29 MSTRG.22183.1_1 - 1e-19 70.6 0.0 2.3e-19 69.4 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 MSTRG.22183.1_1 - 2.8e-13 49.4 0.0 6.1e-13 48.3 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain LIM PF00412.20 MSTRG.22183.1_1 - 2.5e-08 33.9 8.6 7e-08 32.4 8.6 1.8 1 0 0 1 1 1 1 LIM domain FAD_binding_3 PF01494.17 MSTRG.22183.1_1 - 8.5e-06 25.1 0.0 0.00013 21.3 0.0 2.4 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.12 MSTRG.22183.1_1 - 0.00015 21.0 0.0 0.00041 19.6 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 MSTRG.22183.1_1 - 0.00032 19.9 0.0 0.00058 19.1 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 MSTRG.22183.1_1 - 0.00083 18.4 0.3 0.0022 17.0 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.12 MSTRG.22183.1_1 - 0.0023 16.5 0.0 0.0023 16.5 0.0 1.9 3 0 0 3 3 2 1 HI0933-like protein DAO PF01266.22 MSTRG.22183.1_1 - 0.0067 16.0 0.0 0.018 14.5 0.0 1.7 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.4 MSTRG.22183.1_1 - 0.0072 16.4 0.0 0.019 15.0 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.4 MSTRG.22183.1_1 - 0.056 13.8 0.0 0.17 12.2 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding Lycopene_cycl PF05834.10 MSTRG.22183.1_1 - 0.069 12.1 0.0 0.15 11.0 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox PF00070.25 MSTRG.22183.1_1 - 0.079 13.4 0.0 0.23 11.9 0.0 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.15 MSTRG.22183.1_1 - 0.085 11.9 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.20 MSTRG.22183.1_1 - 0.13 11.2 0.0 0.25 10.2 0.0 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.5 MSTRG.22183.1_1 - 0.25 10.5 1.0 0.88 8.7 0.0 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase Sec7 PF01369.18 MSTRG.5197.4_1 - 1.3e-69 233.4 0.6 3.6e-69 232.0 0.6 1.8 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.5 MSTRG.5197.4_1 - 1.5e-50 171.1 6.4 3.4e-50 170.0 3.8 3.1 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.3 MSTRG.5197.4_1 - 2.6e-42 144.4 0.4 2.6e-42 144.4 0.4 3.2 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 DUF1981 PF09324.8 MSTRG.5197.4_1 - 4.9e-36 122.3 0.2 4.9e-36 122.3 0.2 5.1 6 0 0 6 6 6 1 Domain of unknown function (DUF1981) Totivirus_coat PF05518.9 MSTRG.5197.4_1 - 2.2 6.1 6.5 3.4 5.5 6.5 1.2 1 0 0 1 1 1 0 Totivirus coat protein NUDIX PF00293.26 MSTRG.22041.2_2 - 1.2e-16 60.8 0.0 1.9e-16 60.2 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain zf-CCHC PF00098.21 MSTRG.11660.1_1 - 4.4e-05 23.2 1.8 0.0001 22.1 1.8 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.4 MSTRG.11660.1_1 - 0.0038 17.0 1.0 0.0093 15.8 1.0 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.4 MSTRG.11660.1_1 - 0.0066 16.1 1.8 0.016 14.8 1.8 1.7 1 0 0 1 1 1 1 Zinc knuckle Baculo_helicase PF04735.10 MSTRG.11660.1_1 - 0.069 10.5 1.4 0.093 10.1 1.4 1.1 1 0 0 1 1 1 0 Baculovirus DNA helicase zf-CCHC_4 PF14392.4 MSTRG.11660.1_1 - 0.072 12.7 1.0 0.13 11.8 1.0 1.4 1 0 0 1 1 1 0 Zinc knuckle RVP PF00077.18 MSTRG.11660.1_2 - 1.1e-07 32.0 0.0 2.3e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.4 MSTRG.11660.1_2 - 0.00097 19.5 0.0 0.0024 18.3 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.4 MSTRG.11660.1_2 - 0.01 16.3 0.1 0.02 15.5 0.1 1.5 1 1 0 1 1 1 0 Aspartyl protease PWWP PF00855.15 MSTRG.27637.1_1 - 2.1e-13 50.4 0.2 2.1e-13 50.4 0.2 2.5 2 1 0 2 2 2 1 PWWP domain Zona_pellucida PF00100.21 MSTRG.23792.1_2 - 1.1e-29 103.9 0.4 1.1e-29 103.9 0.4 2.0 2 1 0 2 2 2 1 Zona pellucida-like domain SRP1_TIP1 PF00660.15 MSTRG.23792.1_2 - 0.099 12.6 0.4 0.25 11.3 0.2 1.7 2 0 0 2 2 2 0 Seripauperin and TIP1 family HTH_Tnp_Tc3_2 PF01498.16 MSTRG.15402.1_2 - 8.1e-05 22.7 0.6 0.0001 22.3 0.6 1.1 1 0 0 1 1 1 1 Transposase HTH_Tnp_Tc3_2 PF01498.16 MSTRG.15402.1_3 - 2.9e-08 33.7 1.0 3.9e-08 33.3 1.0 1.1 1 0 0 1 1 1 1 Transposase 5_3_exonuc PF01367.18 MSTRG.19576.1_2 - 1.1e-07 32.2 0.0 2.4e-07 31.1 0.0 1.5 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.4 MSTRG.19576.1_2 - 0.0053 17.2 0.0 0.0099 16.4 0.0 1.3 1 0 0 1 1 1 1 Helix-hairpin-helix domain UCH PF00443.27 MSTRG.10970.1_3 - 4.4e-47 160.6 1.0 7.1e-47 159.9 1.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 MSTRG.10970.1_3 - 6.7e-20 71.8 3.2 1.2e-19 71.0 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-4CXXC_R1 PF10497.7 MSTRG.25407.1_1 - 1e-35 121.8 10.9 1.8e-35 121.0 10.9 1.4 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 DNA_ligase_ZBD PF03119.14 MSTRG.9234.1_3 - 0.058 13.3 0.5 0.16 11.9 0.0 2.0 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain Elongin_A PF06881.9 MSTRG.9661.1_3 - 0.0011 19.3 0.5 0.0032 17.8 0.1 1.9 2 0 0 2 2 2 1 RNA polymerase II transcription factor SIII (Elongin) subunit A PRANC PF09372.8 MSTRG.9661.1_3 - 0.17 12.1 2.1 5.6 7.2 0.4 2.6 2 0 0 2 2 2 0 PRANC domain BRCT_2 PF16589.3 MSTRG.22346.2_2 - 5.3e-12 45.8 0.0 9.9e-12 45.0 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.24 MSTRG.22346.2_2 - 2.1e-08 34.3 0.0 3.7e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.3 MSTRG.22346.2_2 - 1.4e-07 31.6 0.0 3e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain PTCB-BRCT PF12738.5 MSTRG.22346.2_2 - 2e-05 24.3 0.0 3.5e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 twin BRCT domain Ig_3 PF13927.4 MSTRG.10052.1_3 - 3.1e-16 59.6 5.9 6.7e-12 45.7 0.3 3.6 4 0 0 4 4 4 2 Immunoglobulin domain V-set PF07686.15 MSTRG.10052.1_3 - 1.5e-15 57.2 1.0 3.5e-10 39.9 0.0 3.8 3 1 1 4 4 4 2 Immunoglobulin V-set domain I-set PF07679.14 MSTRG.10052.1_3 - 1.3e-13 50.7 0.1 7.9e-09 35.3 0.0 3.1 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.10052.1_3 - 3.1e-12 46.5 0.8 8.5e-08 32.3 0.4 2.7 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 MSTRG.10052.1_3 - 8.3e-12 45.0 0.3 2.4e-05 24.3 0.3 2.9 2 1 0 2 2 2 2 Immunoglobulin domain DUF4328 PF14219.4 MSTRG.10052.1_3 - 0.005 16.3 0.3 0.064 12.7 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4328) EphA2_TM PF14575.4 MSTRG.10052.1_3 - 0.043 14.5 0.0 0.16 12.7 0.0 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Phage_holin_3_6 PF07332.9 MSTRG.10052.1_3 - 0.045 13.6 0.2 0.12 12.3 0.0 1.8 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Syndecan PF01034.18 MSTRG.10052.1_3 - 0.16 11.8 0.0 0.37 10.6 0.0 1.5 1 0 0 1 1 1 0 Syndecan domain Response_reg PF00072.22 MSTRG.10052.1_3 - 0.2 11.7 0.0 0.37 10.8 0.0 1.3 1 0 0 1 1 1 0 Response regulator receiver domain AdoHcyase PF05221.15 MSTRG.26620.1_1 - 5.3e-137 455.7 0.0 1.1e-71 241.3 0.3 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.19 MSTRG.26620.1_1 - 8.9e-86 285.8 3.5 1.5e-85 285.1 3.5 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.17 MSTRG.26620.1_1 - 4.5e-10 39.0 0.1 1e-09 37.9 0.1 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.10 MSTRG.26620.1_1 - 5.7e-05 22.6 0.1 9.3e-05 21.9 0.1 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.16 MSTRG.26620.1_1 - 0.0019 18.3 0.1 0.0037 17.4 0.1 1.4 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_7 PF13241.4 MSTRG.26620.1_1 - 0.097 13.0 0.2 0.21 11.9 0.2 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Adaptin_N PF01602.18 MSTRG.16320.3_1 - 3.8e-147 490.9 7.6 4.5e-147 490.6 7.6 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.18 MSTRG.16320.3_1 - 5.5e-10 39.4 0.1 1.1e-09 38.4 0.1 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.5 MSTRG.16320.3_1 - 1.3e-09 38.2 1.1 3.6e-07 30.2 0.0 2.6 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.4 MSTRG.16320.3_1 - 1.1e-05 25.6 1.7 0.0068 16.6 0.1 4.5 3 1 0 3 3 3 1 HEAT repeats RIX1 PF08167.10 MSTRG.16320.3_1 - 2.2e-05 24.2 4.0 0.00066 19.3 0.6 3.5 2 1 0 3 3 3 1 rRNA processing/ribosome biogenesis HEAT PF02985.20 MSTRG.16320.3_1 - 0.0033 17.4 2.0 42 4.6 0.0 4.9 4 0 0 4 4 4 0 HEAT repeat Dymeclin PF09742.7 MSTRG.16320.3_1 - 0.0085 14.5 0.9 0.015 13.7 0.9 1.3 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein IFRD PF05004.11 MSTRG.16320.3_1 - 0.045 12.7 4.4 0.31 10.0 1.4 2.5 2 0 0 2 2 2 0 Interferon-related developmental regulator (IFRD) TIP120 PF08623.8 MSTRG.16320.3_1 - 0.17 11.5 2.3 11 5.6 0.2 2.5 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) Collagen PF01391.16 MSTRG.17144.2_1 - 1.7e-157 511.1 716.7 1.2e-08 34.5 26.0 23.3 5 1 10 15 15 15 6 Collagen triple helix repeat (20 copies) COLFI PF01410.16 MSTRG.17144.2_1 - 1e-92 309.5 0.0 1.4e-92 309.1 0.0 1.2 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Laminin_G_3 PF13385.4 MSTRG.17144.2_1 - 5.3e-06 26.5 0.0 1.1e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.22 MSTRG.17144.2_1 - 1.6e-05 25.4 0.0 3e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.21 MSTRG.17144.2_1 - 0.067 13.3 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Laminin G domain GDI PF00996.16 MSTRG.20703.1_2 - 7.6e-50 169.6 0.0 1.1e-39 136.1 0.0 2.3 3 0 0 3 3 3 2 GDP dissociation inhibitor CDC45 PF02724.12 MSTRG.20703.1_2 - 0.0067 14.7 6.6 0.011 13.9 6.6 1.3 1 0 0 1 1 1 1 CDC45-like protein zf-C3HC4 PF00097.23 MSTRG.8690.1_2 - 4.3e-10 39.2 7.3 1.4e-09 37.6 7.3 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 MSTRG.8690.1_2 - 7.1e-10 38.5 5.2 7.1e-10 38.5 5.2 2.1 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.8690.1_2 - 2.5e-09 37.1 10.0 2.5e-09 37.1 10.0 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.4 MSTRG.8690.1_2 - 2e-08 33.8 8.8 2e-08 33.8 8.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 MSTRG.8690.1_2 - 1.3e-06 28.1 6.1 4e-06 26.6 6.1 1.9 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.4 MSTRG.8690.1_2 - 2.2e-06 27.3 6.7 2.2e-06 27.3 6.7 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.4 MSTRG.8690.1_2 - 2.5e-05 24.1 6.7 2.5e-05 24.1 6.7 2.6 2 1 1 3 3 3 1 RING-type zinc-finger zf-rbx1 PF12678.5 MSTRG.8690.1_2 - 5.2e-05 23.3 7.8 0.00016 21.7 7.8 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.5 MSTRG.8690.1_2 - 7.4e-05 22.6 2.8 0.00014 21.7 2.8 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.4 MSTRG.8690.1_2 - 0.0025 17.8 7.7 0.0025 17.8 7.7 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Baculo_IE-1 PF05290.9 MSTRG.8690.1_2 - 0.0043 16.9 2.4 0.0043 16.9 2.4 1.5 2 0 0 2 2 2 1 Baculovirus immediate-early protein (IE-0) zf-UDP PF14569.4 MSTRG.8690.1_2 - 0.044 13.8 0.7 0.11 12.5 0.7 1.6 1 0 0 1 1 1 0 Zinc-binding RING-finger Rtf2 PF04641.10 MSTRG.8690.1_2 - 0.09 12.0 0.1 0.14 11.4 0.1 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger zf-RING_4 PF14570.4 MSTRG.8690.1_2 - 0.13 11.9 6.1 0.42 10.2 6.1 1.9 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.3 MSTRG.8690.1_2 - 0.14 11.7 4.0 0.43 10.2 4.0 1.9 1 0 0 1 1 1 0 RING-like zinc finger CDC50 PF03381.13 MSTRG.18373.4_1 - 6.1e-25 88.1 0.5 8.6e-25 87.7 0.5 1.2 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family CD20 PF04103.13 MSTRG.18373.4_1 - 0.048 13.6 0.0 0.89 9.5 0.0 2.1 1 1 1 2 2 2 0 CD20-like family Lipoxygenase PF00305.17 MSTRG.2041.1_1 - 1.7e-61 208.4 0.0 3.7e-61 207.3 0.0 1.5 1 1 0 1 1 1 1 Lipoxygenase PLAT PF01477.21 MSTRG.2041.1_2 - 3.5e-19 69.4 0.1 5.8e-19 68.7 0.1 1.3 1 0 0 1 1 1 1 PLAT/LH2 domain Mago-bind PF09282.8 MSTRG.4478.4_1 - 1.5e-13 50.2 3.0 3.1e-13 49.2 3.0 1.5 1 0 0 1 1 1 1 Mago binding Dynactin_p22 PF07426.9 MSTRG.4478.4_1 - 0.06 13.1 3.1 0.12 12.1 3.1 1.4 1 0 0 1 1 1 0 Dynactin subunit p22 CoA_transf_3 PF02515.15 MSTRG.4478.4_1 - 0.1 11.6 0.7 0.14 11.1 0.7 1.1 1 0 0 1 1 1 0 CoA-transferase family III DUF241 PF03087.12 MSTRG.4478.4_1 - 0.52 10.0 5.1 0.73 9.5 5.1 1.1 1 0 0 1 1 1 0 Arabidopsis protein of unknown function DUF733 PF05306.9 MSTRG.4478.4_1 - 2.5 8.3 9.5 7.2 6.9 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF733) Ribosomal_S2 PF00318.18 MSTRG.4478.4_1 - 5.8 6.0 6.1 0.49 9.5 1.0 1.6 2 0 0 2 2 2 0 Ribosomal protein S2 FYTT PF07078.9 MSTRG.12107.2_1 - 1.2e-42 146.2 0.5 2.1e-42 145.5 0.5 1.4 1 0 0 1 1 1 1 Forty-two-three protein FYTT PF07078.9 MSTRG.12107.2_2 - 1.8e-17 63.6 5.5 2.9e-17 62.9 5.5 1.2 1 0 0 1 1 1 1 Forty-two-three protein Myb_DNA-bind_5 PF13873.4 MSTRG.20804.1_1 - 1.9e-22 79.0 0.2 1.9e-22 79.0 0.2 1.6 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.7 MSTRG.20804.1_1 - 0.085 13.1 0.3 0.15 12.3 0.3 1.4 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like zf-RVT PF13966.4 MSTRG.5999.1_3 - 0.0075 17.0 1.3 0.0075 17.0 1.3 2.4 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase Helicase_C PF00271.29 MSTRG.11744.1_2 - 1.6e-16 60.5 0.0 5e-16 58.9 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.27 MSTRG.11744.1_2 - 1.2e-14 54.3 0.0 2.2e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.3 MSTRG.11744.1_2 - 2.3e-11 44.1 3.6 6e-11 42.8 3.6 1.8 1 0 0 1 1 1 1 RecQ zinc-binding RQC PF09382.8 MSTRG.11744.1_2 - 0.0025 17.4 0.0 0.0096 15.6 0.0 2.0 1 1 0 1 1 1 1 RQC domain ResIII PF04851.13 MSTRG.11744.1_2 - 0.13 12.2 0.0 0.28 11.0 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DUF1736 PF08409.9 MSTRG.15325.1_3 - 4.6e-32 109.7 0.7 8.5e-32 108.9 0.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1736) ABC_tran PF00005.25 MSTRG.13306.5_2 - 1.5e-47 161.4 0.0 4.7e-24 85.3 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_tran_Xtn PF12848.5 MSTRG.13306.5_2 - 5.9e-22 77.3 4.7 5.9e-22 77.3 4.7 3.8 4 0 0 4 4 3 1 ABC transporter AAA_21 PF13304.4 MSTRG.13306.5_2 - 1.2e-16 61.3 0.1 0.00016 21.5 0.0 4.2 3 1 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.17 MSTRG.13306.5_2 - 1.5e-06 27.7 0.8 1.4 8.1 0.0 3.6 2 2 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.4 MSTRG.13306.5_2 - 2.2e-06 27.1 1.6 0.003 17.1 0.0 2.8 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_33 PF13671.4 MSTRG.13306.5_2 - 5.3e-05 23.3 0.1 0.063 13.3 0.0 3.1 4 0 0 4 4 2 1 AAA domain DUF258 PF03193.14 MSTRG.13306.5_2 - 0.00043 20.1 0.1 0.0088 15.8 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 MSTRG.13306.5_2 - 0.00085 19.3 0.0 0.091 12.7 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_28 PF13521.4 MSTRG.13306.5_2 - 0.0021 18.2 0.0 1.3 9.1 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.4 MSTRG.13306.5_2 - 0.0023 18.2 0.0 0.26 11.5 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.4 MSTRG.13306.5_2 - 0.0029 18.0 0.2 0.36 11.2 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA PF00004.27 MSTRG.13306.5_2 - 0.0037 17.6 0.0 1.3 9.3 0.0 2.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 MSTRG.13306.5_2 - 0.0043 17.2 0.0 0.68 10.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.4 MSTRG.13306.5_2 - 0.0045 16.6 0.0 0.65 9.6 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.4 MSTRG.13306.5_2 - 0.018 14.5 0.0 0.92 8.9 0.0 2.7 3 0 0 3 3 3 0 AAA domain NACHT PF05729.10 MSTRG.13306.5_2 - 0.018 14.8 1.0 0.86 9.4 0.0 2.8 3 0 0 3 3 2 0 NACHT domain AAA_15 PF13175.4 MSTRG.13306.5_2 - 0.019 14.5 0.0 0.019 14.5 0.0 3.7 5 0 0 5 5 5 0 AAA ATPase domain AAA_14 PF13173.4 MSTRG.13306.5_2 - 0.02 14.8 0.0 1.1 9.2 0.0 2.9 3 0 0 3 3 2 0 AAA domain AAA_27 PF13514.4 MSTRG.13306.5_2 - 0.021 14.3 0.8 3.7 6.9 0.0 3.2 3 0 0 3 3 3 0 AAA domain Dynamin_N PF00350.21 MSTRG.13306.5_2 - 0.022 14.7 0.4 0.3 11.0 0.0 3.0 4 0 0 4 4 4 0 Dynamin family AAA_24 PF13479.4 MSTRG.13306.5_2 - 0.029 14.0 0.9 1.6 8.3 0.0 3.2 4 0 0 4 4 4 0 AAA domain AAA_23 PF13476.4 MSTRG.13306.5_2 - 0.035 14.5 0.0 0.035 14.5 0.0 4.1 5 0 0 5 5 4 0 AAA domain RNA_helicase PF00910.20 MSTRG.13306.5_2 - 0.096 13.0 0.0 0.77 10.0 0.0 2.3 2 0 0 2 2 2 0 RNA helicase AAA_5 PF07728.12 MSTRG.13306.5_2 - 0.13 12.1 0.2 14 5.6 0.2 2.6 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) ArgK PF03308.14 MSTRG.13306.5_2 - 0.27 10.0 2.6 6 5.6 0.0 2.7 3 0 0 3 3 3 0 ArgK protein Rop PF01815.14 MSTRG.13306.5_2 - 0.4 10.5 6.6 0.28 10.9 0.1 2.8 2 1 1 3 3 3 0 Rop protein TK PF00265.16 MSTRG.19082.1_3 - 1.5e-69 233.3 0.2 2.1e-69 232.8 0.2 1.2 1 0 0 1 1 1 1 Thymidine kinase Lectin_C PF00059.19 MSTRG.25279.2_2 - 6.6e-17 62.1 1.1 6.6e-17 62.1 1.1 1.6 2 0 0 2 2 2 1 Lectin C-type domain UL45 PF05473.10 MSTRG.25279.2_2 - 0.0027 17.3 0.1 0.0057 16.2 0.1 1.6 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Selenoprotein_S PF06936.9 MSTRG.25279.2_2 - 0.0087 15.8 0.4 0.015 14.9 0.4 1.3 1 0 0 1 1 1 1 Selenoprotein S (SelS) DUF4279 PF14106.4 MSTRG.25279.2_2 - 0.08 13.0 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4279) DUF4200 PF13863.4 MSTRG.25279.2_2 - 0.43 10.8 7.6 0.2 11.9 2.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) DUF2188 PF09954.7 MSTRG.25279.2_3 - 0.16 12.0 0.3 0.27 11.3 0.3 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2188) Lectin_C PF00059.19 MSTRG.20834.4_1 - 8.4e-25 87.5 2.3 1.4e-24 86.7 0.9 2.2 2 0 0 2 2 1 1 Lectin C-type domain HALZ PF02183.16 MSTRG.20834.4_1 - 6.4e-12 45.4 94.9 0.012 15.7 2.8 14.6 5 2 10 15 15 14 9 Homeobox associated leucine zipper JIP_LZII PF16471.3 MSTRG.20834.4_1 - 1.4e-11 44.2 57.3 0.0021 18.1 0.9 8.4 3 2 6 9 9 9 4 JNK-interacting protein leucine zipper II APG6 PF04111.10 MSTRG.20834.4_1 - 1.3e-08 34.5 70.0 0.013 14.8 10.0 5.1 1 1 4 5 5 5 4 Autophagy protein Apg6 Spc7 PF08317.9 MSTRG.20834.4_1 - 8e-07 28.1 62.8 0.043 12.6 12.0 5.4 1 1 4 5 5 5 5 Spc7 kinetochore protein Scaffolding_pro PF11418.6 MSTRG.20834.4_1 - 1.4e-05 25.4 31.6 2.2 8.8 0.1 7.8 2 1 4 8 8 8 3 Phi29 scaffolding protein SHE3 PF17078.3 MSTRG.20834.4_1 - 0.00013 21.6 28.9 0.00013 21.6 28.9 3.7 1 1 2 3 3 3 1 SWI5-dependent HO expression protein 3 TMF_TATA_bd PF12325.6 MSTRG.20834.4_1 - 0.00077 19.5 57.7 0.3 11.2 4.9 7.5 1 1 7 9 9 9 4 TATA element modulatory factor 1 TATA binding KASH_CCD PF14662.4 MSTRG.20834.4_1 - 0.0023 17.7 64.3 0.47 10.2 22.0 5.8 1 1 3 4 4 4 2 Coiled-coil region of CCDC155 or KASH GAS PF13851.4 MSTRG.20834.4_1 - 0.0064 15.7 70.5 0.034 13.4 16.2 6.2 1 1 6 7 7 7 3 Growth-arrest specific micro-tubule binding DUF3450 PF11932.6 MSTRG.20834.4_1 - 0.0075 15.5 62.6 0.031 13.4 8.4 6.4 1 1 4 7 7 7 6 Protein of unknown function (DUF3450) CENP-F_leu_zip PF10473.7 MSTRG.20834.4_1 - 0.014 15.3 63.9 0.16 11.9 9.5 6.6 1 1 6 7 7 7 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF2353 PF09789.7 MSTRG.20834.4_1 - 0.021 14.1 67.7 0.051 12.9 20.6 4.4 1 1 3 4 4 4 0 Uncharacterized coiled-coil protein (DUF2353) DUF1664 PF07889.10 MSTRG.20834.4_1 - 0.028 14.3 36.0 0.073 12.9 1.0 5.8 3 1 3 6 6 6 0 Protein of unknown function (DUF1664) WXG100 PF06013.10 MSTRG.20834.4_1 - 0.11 12.6 24.1 1.1 9.4 0.4 6.7 6 1 1 7 7 6 0 Proteins of 100 residues with WXG ZapB PF06005.10 MSTRG.20834.4_1 - 0.12 12.7 63.5 4.2 7.8 2.9 8.5 4 1 4 8 8 8 0 Cell division protein ZapB DUF4407 PF14362.4 MSTRG.20834.4_1 - 0.31 10.2 43.7 0.3 10.3 15.7 3.9 1 1 3 4 4 4 0 Domain of unknown function (DUF4407) DUF5082 PF16888.3 MSTRG.20834.4_1 - 1 9.6 52.7 0.29 11.4 3.7 6.8 3 2 2 5 5 5 0 Domain of unknown function (DUF5082) DUF4472 PF14739.4 MSTRG.20834.4_1 - 1.5 9.5 56.7 3.1 8.4 3.8 7.8 2 1 7 9 9 8 0 Domain of unknown function (DUF4472) CALCOCO1 PF07888.9 MSTRG.20834.4_1 - 2 6.7 58.3 1.2 7.5 14.2 3.3 1 1 2 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like Tup_N PF08581.8 MSTRG.20834.4_1 - 3 8.1 52.9 0.92 9.7 1.8 7.6 4 3 4 8 8 8 0 Tup N-terminal Sec34 PF04136.13 MSTRG.20834.4_1 - 3.4 7.4 53.1 0.2 11.4 8.5 6.9 2 2 3 7 7 7 0 Sec34-like family ERM PF00769.17 MSTRG.20834.4_1 - 5.2 6.7 49.3 9.8 5.8 0.2 4.3 1 1 2 3 3 3 0 Ezrin/radixin/moesin family EzrA PF06160.10 MSTRG.20834.4_1 - 7.7 4.4 62.7 0.51 8.3 26.4 3.5 1 1 2 3 3 3 0 Septation ring formation regulator, EzrA CASP_C PF08172.10 MSTRG.20834.4_1 - 7.9 5.6 49.6 0.14 11.4 12.1 5.0 3 2 2 5 5 5 0 CASP C terminal IncA PF04156.12 MSTRG.20834.4_1 - 9.1 5.9 64.9 0.46 10.1 8.0 5.3 1 1 4 5 5 5 0 IncA protein DUF2316 PF10078.7 MSTRG.20834.4_1 - 9.3 6.5 12.5 0.24 11.5 2.1 3.5 3 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2316) AKAP95 PF04988.10 MSTRG.27700.4_3 - 7.4e-67 224.5 9.5 1.5e-66 223.6 9.5 1.5 1 0 0 1 1 1 1 A-kinase anchoring protein 95 (AKAP95) Actin_micro PF17003.3 MSTRG.27700.4_3 - 0.02 14.0 11.4 0.28 10.2 2.4 2.2 1 1 1 2 2 2 0 Putative actin-like family zf-H2C2_5 PF13909.4 MSTRG.27700.4_3 - 0.031 13.9 0.6 0.14 11.9 0.6 2.1 1 0 0 1 1 1 0 C2H2-type zinc-finger domain BUD22 PF09073.8 MSTRG.27700.4_3 - 0.17 11.0 19.9 0.26 10.5 19.9 1.2 1 0 0 1 1 1 0 BUD22 Rap_GAP PF02145.13 MSTRG.9381.1_3 - 2.1e-68 229.5 0.0 3.1e-68 228.9 0.0 1.3 1 0 0 1 1 1 1 Rap/ran-GAP ZapB PF06005.10 MSTRG.9381.1_3 - 0.00013 22.2 11.5 0.00036 20.8 11.5 1.7 1 0 0 1 1 1 1 Cell division protein ZapB OmpH PF03938.12 MSTRG.9381.1_3 - 0.0062 16.4 4.6 0.086 12.7 5.3 2.2 2 0 0 2 2 2 1 Outer membrane protein (OmpH-like) SKA1 PF07160.10 MSTRG.9381.1_3 - 0.011 15.4 1.4 0.029 14.1 1.4 1.6 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 PI3K_P85_iSH2 PF16454.3 MSTRG.9381.1_3 - 0.049 13.1 3.0 0.099 12.1 3.0 1.4 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF972 PF06156.11 MSTRG.9381.1_3 - 0.091 13.3 5.5 0.25 11.8 5.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF972) DUF1297 PF06973.10 MSTRG.9381.1_3 - 0.12 11.8 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1297) EMP24_GP25L PF01105.22 MSTRG.9381.1_3 - 0.17 11.6 1.1 0.41 10.4 1.1 1.6 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF2968 PF11180.6 MSTRG.9381.1_3 - 0.27 10.8 6.7 0.59 9.7 6.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) ADIP PF11559.6 MSTRG.9381.1_3 - 0.35 10.8 6.8 0.79 9.7 6.8 1.6 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.9 MSTRG.9381.1_3 - 0.53 10.3 17.0 0.1 12.6 12.7 2.0 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) APG6 PF04111.10 MSTRG.9381.1_3 - 0.91 8.7 8.0 1.6 7.9 8.0 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Bap31 PF05529.10 MSTRG.9381.1_3 - 0.92 8.9 4.0 2 7.8 4.0 1.5 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like IncA PF04156.12 MSTRG.9381.1_3 - 0.95 9.1 21.8 0.61 9.7 17.7 2.7 2 1 0 2 2 2 0 IncA protein Macoilin PF09726.7 MSTRG.9381.1_3 - 0.96 7.8 9.8 1.4 7.2 9.8 1.2 1 0 0 1 1 1 0 Transmembrane protein DUF4140 PF13600.4 MSTRG.9381.1_3 - 1 9.7 4.4 2.5 8.5 3.9 2.0 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) HAUS-augmin3 PF14932.4 MSTRG.9381.1_3 - 1.7 8.0 12.8 1.8 7.9 9.8 2.3 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 Spectrin PF00435.19 MSTRG.9381.1_3 - 3.9 7.9 10.2 1.7 9.0 5.7 2.3 2 0 0 2 2 2 0 Spectrin repeat DivIC PF04977.13 MSTRG.9381.1_3 - 4 7.2 9.4 10 5.9 9.4 1.6 1 0 0 1 1 1 0 Septum formation initiator DUF4964 PF16334.3 MSTRG.22483.1_1 - 0.045 13.2 0.1 0.097 12.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4964) WD40 PF00400.30 MSTRG.22483.1_2 - 9.6e-06 26.1 3.2 0.004 17.8 0.3 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat Ribosomal_S25 PF03297.13 MSTRG.22483.1_2 - 0.13 12.4 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 S25 ribosomal protein Pkinase PF00069.23 MSTRG.24784.2_1 - 1.2e-112 375.5 0.2 3.3e-55 187.2 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.24784.2_1 - 1.4e-59 201.4 0.3 1.1e-33 116.5 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase I-set PF07679.14 MSTRG.24784.2_1 - 6.4e-17 61.3 0.0 1.7e-16 59.9 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.24784.2_1 - 6.1e-14 52.3 0.0 2.7e-13 50.2 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.24784.2_1 - 1.1e-07 31.9 0.0 3.3e-07 30.4 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 MSTRG.24784.2_1 - 9.5e-07 28.8 0.0 3.1e-06 27.1 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain fn3 PF00041.19 MSTRG.24784.2_1 - 1.6e-06 28.3 0.1 3.7e-06 27.1 0.1 1.7 1 0 0 1 1 1 1 Fibronectin type III domain Kinase-like PF14531.4 MSTRG.24784.2_1 - 1.8e-06 27.3 0.0 0.0016 17.7 0.0 2.6 2 1 0 2 2 2 2 Kinase-like Kdo PF06293.12 MSTRG.24784.2_1 - 6e-05 22.4 1.7 0.13 11.4 1.3 2.5 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family V-set PF07686.15 MSTRG.24784.2_1 - 0.0086 16.1 0.0 0.92 9.6 0.0 2.8 1 1 0 1 1 1 1 Immunoglobulin V-set domain APH PF01636.21 MSTRG.24784.2_1 - 0.011 15.6 0.0 0.17 11.7 0.0 2.4 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.9 MSTRG.24784.2_1 - 0.064 12.1 0.6 2.5 6.8 0.1 2.1 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase efThoc1 PF11957.6 MSTRG.12862.1_3 - 2.9e-142 474.7 7.0 4.1e-142 474.2 7.0 1.2 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor Death PF00531.20 MSTRG.12862.1_3 - 1.2e-12 47.7 3.5 2.6e-12 46.6 1.0 2.4 2 0 0 2 2 2 1 Death domain HsdM_N PF12161.6 MSTRG.12862.1_3 - 3.8 8.0 7.7 0.57 10.7 0.4 2.9 3 1 1 4 4 4 0 HsdM N-terminal domain Pax2_C PF12403.6 MSTRG.11381.1_2 - 8.1e-29 99.9 6.8 1.1e-28 99.4 6.8 1.2 1 0 0 1 1 1 1 Paired-box protein 2 C terminal Peptidase_M16_C PF05193.19 MSTRG.8961.1_1 - 5.2e-08 33.0 0.1 9.3e-08 32.2 0.1 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain WW PF00397.24 MSTRG.22141.5_2 - 5.3e-18 64.5 15.8 5.9e-09 35.6 2.1 2.6 2 0 0 2 2 2 2 WW domain PRY PF13765.4 MSTRG.24130.1_2 - 1.6e-16 59.5 0.4 4.1e-16 58.2 0.4 1.8 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 MSTRG.24130.1_2 - 9.4e-15 54.7 0.1 1.7e-14 53.9 0.1 1.4 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_2 PF13923.4 MSTRG.24130.1_2 - 2.1e-06 27.3 16.5 6e-06 25.9 16.5 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 MSTRG.24130.1_2 - 4e-06 26.7 17.5 4e-06 26.7 17.5 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 MSTRG.24130.1_2 - 6.4e-06 25.8 16.1 1.7e-05 24.5 16.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 MSTRG.24130.1_2 - 7.6e-06 25.6 12.6 7.6e-06 25.6 12.6 2.1 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.24130.1_2 - 1.8e-05 24.5 14.2 1.8e-05 24.5 14.2 2.3 2 0 0 2 2 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 MSTRG.24130.1_2 - 0.00015 21.8 17.1 0.00015 21.8 17.1 2.3 2 0 0 2 2 1 1 Ring finger domain zf-RING_5 PF14634.4 MSTRG.24130.1_2 - 0.008 16.0 14.8 0.008 16.0 14.8 2.0 2 0 0 2 2 1 1 zinc-RING finger domain zf-RING_6 PF14835.4 MSTRG.24130.1_2 - 0.025 14.3 6.5 0.052 13.3 6.5 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Mt_ATP-synt_D PF05873.10 MSTRG.24130.1_2 - 0.084 12.6 6.7 0.21 11.3 6.7 1.6 1 1 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) ATPase PF06745.11 MSTRG.24130.1_2 - 0.2 10.9 3.2 0.24 10.6 2.2 1.5 2 0 0 2 2 2 0 KaiC DUF106 PF01956.14 MSTRG.24130.1_2 - 0.26 10.9 0.9 0.47 10.1 0.4 1.6 1 1 0 1 1 1 0 Integral membrane protein DUF106 Atg14 PF10186.7 MSTRG.24130.1_2 - 0.81 8.6 10.5 1.6 7.6 10.5 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Asp-B-Hydro_N PF05279.9 MSTRG.24130.1_2 - 1 9.2 11.9 1.8 8.4 11.9 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF1640 PF07798.9 MSTRG.24130.1_2 - 1.1 9.2 9.8 2 8.3 9.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) OmpH PF03938.12 MSTRG.24130.1_2 - 1.9 8.4 13.4 3.3 7.6 13.4 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) LUC7 PF03194.13 MSTRG.24130.1_2 - 4.8 6.6 14.2 5.5 6.4 13.4 1.3 1 1 0 1 1 1 0 LUC7 N_terminus Prok-RING_4 PF14447.4 MSTRG.24130.1_2 - 5.1 6.9 20.9 0.067 12.9 13.0 2.0 2 0 0 2 2 1 0 Prokaryotic RING finger family 4 zf-Nse PF11789.6 MSTRG.24130.1_2 - 6.2 6.6 8.9 16 5.3 8.9 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit PMP22_Claudin PF00822.18 MSTRG.24130.1_3 - 6e-27 94.4 7.4 8.7e-27 93.9 7.4 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 MSTRG.24130.1_3 - 9.5e-05 22.1 10.2 0.00031 20.4 9.9 1.9 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Clc-like PF07062.10 MSTRG.24130.1_3 - 3.4 7.0 6.4 1.2 8.4 1.7 2.0 2 0 0 2 2 2 0 Clc-like CHDNT PF08073.10 MSTRG.10690.11_1 - 2.9 7.7 28.1 38 4.1 0.1 7.7 7 0 0 7 7 7 0 CHDNT (NUC034) domain Glyco_hydro_18 PF00704.26 MSTRG.4491.2_1 - 3e-95 319.4 0.0 3.7e-95 319.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_14 PF01607.22 MSTRG.4491.2_1 - 3.9e-08 33.2 10.5 7.3e-08 32.3 10.5 1.5 1 0 0 1 1 1 1 Chitin binding Peritrophin-A domain SCHIP-1 PF10148.7 MSTRG.9997.4_3 - 1.6e-106 355.1 10.1 1.9e-106 354.8 10.1 1.0 1 0 0 1 1 1 1 Schwannomin-interacting protein 1 FEZ PF07763.11 MSTRG.9997.4_3 - 0.0045 16.6 7.4 0.0082 15.8 7.4 1.4 1 1 0 1 1 1 1 FEZ-like protein DUF5102 PF17104.3 MSTRG.9997.4_3 - 0.053 13.4 6.9 0.077 12.9 6.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5102) EBP50_C PF09007.9 MSTRG.9997.4_3 - 0.22 12.4 4.6 0.47 11.3 4.6 1.4 1 0 0 1 1 1 0 EBP50, C-terminal WD40 PF00400.30 MSTRG.1158.1_3 - 1.9e-15 56.8 17.1 3.2e-07 30.8 1.0 6.1 7 0 0 7 7 7 4 WD domain, G-beta repeat FYVE PF01363.19 MSTRG.1158.1_3 - 6.2e-13 48.5 6.8 6.2e-13 48.5 6.8 2.1 2 0 0 2 2 2 1 FYVE zinc finger ANAPC4_WD40 PF12894.5 MSTRG.1158.1_3 - 4e-05 23.7 0.1 0.23 11.6 0.0 4.0 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Glyco_transf_22 PF03901.15 MSTRG.17307.1_1 - 3e-20 72.7 0.5 4.9e-20 72.0 0.5 1.4 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family ELO PF01151.16 MSTRG.23087.1_2 - 3.5e-12 46.3 0.2 4.4e-12 45.9 0.2 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family RCC1 PF00415.16 MSTRG.15136.1_2 - 2.7e-74 245.5 28.7 6.4e-14 52.2 0.5 7.6 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 MSTRG.15136.1_2 - 1.9e-36 123.0 34.7 2.2e-07 30.4 1.3 8.4 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat HECT PF00632.23 MSTRG.15136.1_3 - 5.1e-07 29.3 0.0 6.8e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) FHA PF00498.24 MSTRG.12969.4_2 - 1.6e-16 60.3 0.0 3e-16 59.4 0.0 1.5 1 0 0 1 1 1 1 FHA domain HALZ PF02183.16 MSTRG.12969.4_2 - 0.00033 20.7 4.0 0.00033 20.7 4.0 5.1 5 0 0 5 5 5 1 Homeobox associated leucine zipper WD40 PF00400.30 MSTRG.9778.1_2 - 1.5e-06 28.7 6.1 0.00026 21.6 0.5 4.6 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.9778.1_2 - 0.0002 21.5 0.0 0.18 12.0 0.0 3.8 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain SR-25 PF10500.7 MSTRG.9778.1_2 - 4.4 6.7 11.0 3.3 7.1 4.0 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DDE_Tnp_4 PF13359.4 MSTRG.8957.1_1 - 3.5e-19 68.9 0.0 5.3e-19 68.3 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_4 PF13613.4 MSTRG.8957.1_1 - 1.2e-06 28.0 1.2 0.00039 20.0 0.0 3.0 3 0 0 3 3 3 2 Helix-turn-helix of DDE superfamily endonuclease Plant_tran PF04827.12 MSTRG.8957.1_1 - 0.00048 19.6 0.0 0.00073 19.1 0.0 1.2 1 0 0 1 1 1 1 Plant transposon protein HTH_23 PF13384.4 MSTRG.8957.1_1 - 0.041 13.6 0.0 0.13 12.0 0.0 1.8 1 0 0 1 1 1 0 Homeodomain-like domain RIIa PF02197.15 MSTRG.8957.1_2 - 0.0083 15.6 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Ribophorin_I PF04597.12 MSTRG.13625.2_2 - 1.2e-144 482.7 4.6 1.5e-144 482.3 4.6 1.1 1 0 0 1 1 1 1 Ribophorin I FliD_C PF07195.10 MSTRG.13625.2_2 - 0.021 14.1 0.1 0.037 13.3 0.1 1.3 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus Glyco_transf_64 PF09258.8 MSTRG.6210.1_3 - 2.7e-99 331.3 0.1 3.9e-99 330.8 0.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Exostosin PF03016.13 MSTRG.6210.1_3 - 6.4e-53 179.8 0.0 9.5e-53 179.2 0.0 1.3 1 0 0 1 1 1 1 Exostosin family ADIP PF11559.6 MSTRG.6210.1_3 - 0.0066 16.4 5.1 0.01 15.8 5.1 1.2 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding DUF3678 PF12435.6 MSTRG.6210.1_3 - 0.075 12.1 0.2 0.16 11.1 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3678) MscS_porin PF12795.5 MSTRG.6210.1_3 - 0.18 11.2 2.8 0.28 10.6 2.8 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain TPR_MLP1_2 PF07926.10 MSTRG.6210.1_3 - 0.21 11.5 4.9 0.33 10.9 4.9 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF1664 PF07889.10 MSTRG.6210.1_3 - 0.41 10.5 1.1 0.75 9.7 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Ribosomal_S19e PF01090.17 MSTRG.18506.1_1 - 0.023 14.3 0.0 0.025 14.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein S19e DUF1356 PF07092.10 MSTRG.18506.1_1 - 0.23 10.5 0.2 0.26 10.4 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1356) PP2C PF00481.19 MSTRG.27611.1_1 - 7.3e-53 179.7 0.1 1e-52 179.2 0.1 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.4 MSTRG.27611.1_1 - 9.3e-08 31.8 0.1 1.7e-07 31.0 0.1 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C Drf_GBD PF06371.11 MSTRG.16079.1_2 - 5.9e-54 182.4 2.7 1.1e-53 181.4 2.7 1.4 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.14 MSTRG.16079.1_2 - 3.3e-33 114.8 0.4 3.3e-33 114.8 0.4 2.2 3 0 0 3 3 3 1 Diaphanous FH3 Domain PUL PF08324.9 MSTRG.16079.1_2 - 0.004 16.4 0.4 0.0095 15.1 0.3 1.6 1 1 1 2 2 2 1 PUL domain DUF3361 PF11841.6 MSTRG.16079.1_2 - 0.016 15.0 3.7 0.86 9.4 0.2 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF3361) LRRNT_2 PF08263.10 MSTRG.932.1_3 - 0.0037 17.4 2.4 0.015 15.4 0.3 2.3 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain FAM27 PF15832.3 MSTRG.12382.1_2 - 0.27 11.7 4.9 0.42 11.0 4.9 1.2 1 0 0 1 1 1 0 FAM27 D and E protein family ADAM_spacer1 PF05986.12 MSTRG.12444.2_2 - 0.0012 18.7 0.0 0.002 18.0 0.0 1.2 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Reprolysin PF01421.17 MSTRG.12444.2_3 - 5.2e-24 85.1 0.1 8.3e-24 84.5 0.1 1.3 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.4 MSTRG.12444.2_3 - 2.8e-15 56.8 1.3 4.9e-15 56.1 1.3 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 ADAM_spacer1 PF05986.12 MSTRG.12444.2_3 - 3.4e-13 49.5 0.0 6.4e-13 48.6 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Reprolysin_3 PF13582.4 MSTRG.12444.2_3 - 8.6e-13 48.8 1.0 1.7e-12 47.8 1.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Pep_M12B_propep PF01562.17 MSTRG.12444.2_3 - 2.7e-12 47.0 0.0 5.7e-12 45.9 0.0 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide TSP_1 PF00090.17 MSTRG.12444.2_3 - 2.9e-08 33.7 7.7 2.9e-08 33.7 7.7 3.0 2 0 0 2 2 2 1 Thrombospondin type 1 domain Reprolysin_2 PF13574.4 MSTRG.12444.2_3 - 2.3e-05 24.2 0.3 4.1e-05 23.4 0.3 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 MSTRG.12444.2_3 - 6.9e-05 22.4 0.2 0.00011 21.8 0.2 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.22 MSTRG.12444.2_3 - 0.0068 16.1 2.4 0.019 14.7 2.4 1.6 1 1 0 1 1 1 1 Matrixin DUF4953 PF16313.3 MSTRG.12444.2_3 - 0.17 10.9 0.7 0.28 10.2 0.7 1.2 1 0 0 1 1 1 0 Met-zincin Lectin_C PF00059.19 MSTRG.23459.1_3 - 8.6e-20 71.4 0.7 2.2e-19 70.1 0.7 1.7 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 MSTRG.23459.1_3 - 3.7e-19 68.1 86.2 8.6e-08 31.7 21.2 3.3 1 1 2 3 3 3 3 Collagen triple helix repeat (20 copies) Filament PF00038.19 MSTRG.23459.1_3 - 0.00039 20.0 9.7 0.00039 20.0 9.7 2.2 2 1 0 2 2 2 1 Intermediate filament protein Fib_alpha PF08702.8 MSTRG.23459.1_3 - 0.0034 17.4 6.5 0.56 10.3 0.1 3.2 2 2 1 3 3 3 2 Fibrinogen alpha/beta chain family DUF1640 PF07798.9 MSTRG.23459.1_3 - 0.0042 17.0 0.2 0.0042 17.0 0.2 3.1 2 1 1 3 3 3 1 Protein of unknown function (DUF1640) EzrA PF06160.10 MSTRG.23459.1_3 - 0.0042 15.2 6.7 0.0079 14.3 4.6 2.3 2 1 0 2 2 2 1 Septation ring formation regulator, EzrA Ly49 PF08391.8 MSTRG.23459.1_3 - 0.022 15.0 0.2 0.39 11.0 0.0 2.6 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region Alpha-2-MRAP_C PF06401.9 MSTRG.23459.1_3 - 0.027 14.3 1.2 0.063 13.1 1.2 1.5 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, C-terminal domain Fez1 PF06818.13 MSTRG.23459.1_3 - 0.036 14.4 9.4 2.3 8.5 1.0 2.8 1 1 1 2 2 2 0 Fez1 Reo_sigmaC PF04582.10 MSTRG.23459.1_3 - 0.042 13.1 19.0 3.1 7.0 0.3 3.7 1 1 3 4 4 4 0 Reovirus sigma C capsid protein Prefoldin PF02996.15 MSTRG.23459.1_3 - 0.058 13.2 3.6 0.21 11.4 0.4 3.1 4 0 0 4 4 2 0 Prefoldin subunit DUF3130 PF11328.6 MSTRG.23459.1_3 - 0.058 13.5 0.2 0.76 9.9 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3130 IMD PF08397.9 MSTRG.23459.1_3 - 0.086 12.1 1.5 0.21 10.8 1.5 1.6 1 0 0 1 1 1 0 IRSp53/MIM homology domain DUF1664 PF07889.10 MSTRG.23459.1_3 - 0.26 11.1 13.2 11 5.9 0.2 4.5 2 1 4 6 6 6 0 Protein of unknown function (DUF1664) OmpH PF03938.12 MSTRG.23459.1_3 - 0.46 10.3 12.0 0.89 9.4 9.1 2.6 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) FlaC_arch PF05377.9 MSTRG.23459.1_3 - 0.79 10.0 5.3 30 5.0 0.0 4.5 5 0 0 5 5 4 0 Flagella accessory protein C (FlaC) DivIC PF04977.13 MSTRG.23459.1_3 - 0.96 9.1 9.6 1.1 8.9 2.4 3.0 3 0 0 3 3 2 0 Septum formation initiator COG2 PF06148.9 MSTRG.23459.1_3 - 1.1 9.2 7.4 0.95 9.4 0.0 3.9 2 2 1 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 IncA PF04156.12 MSTRG.23459.1_3 - 1.3 8.6 16.6 68 3.0 11.4 3.9 1 1 1 2 2 2 0 IncA protein ZapB PF06005.10 MSTRG.23459.1_3 - 1.3 9.4 11.3 1.3 9.3 4.3 3.5 3 1 0 3 3 3 0 Cell division protein ZapB WEMBL PF05701.9 MSTRG.23459.1_3 - 1.5 7.3 14.0 0.25 9.8 6.9 2.7 2 1 2 4 4 4 0 Weak chloroplast movement under blue light Nup54 PF13874.4 MSTRG.23459.1_3 - 1.5 8.8 10.6 10 6.1 0.2 3.6 2 1 1 3 3 3 0 Nucleoporin complex subunit 54 KASH_CCD PF14662.4 MSTRG.23459.1_3 - 1.6 8.4 10.2 0.48 10.1 5.1 2.5 3 0 0 3 3 3 0 Coiled-coil region of CCDC155 or KASH DUF948 PF06103.9 MSTRG.23459.1_3 - 1.6 8.9 17.5 26 5.0 1.6 5.2 2 1 2 5 5 5 0 Bacterial protein of unknown function (DUF948) V_ATPase_I PF01496.17 MSTRG.23459.1_3 - 1.6 6.4 5.5 3.8 5.2 1.0 2.1 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family DUF4795 PF16043.3 MSTRG.23459.1_3 - 1.7 8.0 8.2 3.6 7.0 5.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) CALCOCO1 PF07888.9 MSTRG.23459.1_3 - 2 6.7 12.6 1.3 7.3 10.1 1.7 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like KxDL PF10241.7 MSTRG.23459.1_3 - 2 8.6 11.1 0.43 10.7 3.0 3.4 4 0 0 4 4 3 0 Uncharacterized conserved protein Snapin_Pallidin PF14712.4 MSTRG.23459.1_3 - 2.1 8.7 13.2 0.61 10.4 0.3 4.2 4 1 0 4 4 4 0 Snapin/Pallidin DUF4407 PF14362.4 MSTRG.23459.1_3 - 2.4 7.3 22.1 6.4 5.9 18.5 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) DUF3584 PF12128.6 MSTRG.23459.1_3 - 2.5 5.4 16.9 29 1.8 14.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3584) Golgin_A5 PF09787.7 MSTRG.23459.1_3 - 3.6 6.8 11.2 0.83 8.9 1.1 2.7 1 1 2 3 3 3 0 Golgin subfamily A member 5 IFT20 PF14931.4 MSTRG.23459.1_3 - 4.6 7.3 7.1 2.6 8.1 1.9 2.7 3 0 0 3 3 3 0 Intraflagellar transport complex B, subunit 20 DASH_Duo1 PF08651.8 MSTRG.23459.1_3 - 4.9 6.9 7.0 25 4.6 0.3 4.4 6 0 0 6 6 4 0 DASH complex subunit Duo1 Laminin_II PF06009.10 MSTRG.23459.1_3 - 5.3 6.9 15.9 5.7 6.8 6.6 3.4 2 1 0 3 3 3 0 Laminin Domain II V-SNARE PF05008.13 MSTRG.23459.1_3 - 5.5 7.3 6.5 11 6.4 0.8 3.5 3 1 0 3 3 3 0 Vesicle transport v-SNARE protein N-terminus FUSC PF04632.10 MSTRG.23459.1_3 - 7.1 4.9 9.5 2.7 6.3 0.2 2.2 1 1 0 2 2 2 0 Fusaric acid resistance protein family Mnd1 PF03962.13 MSTRG.23459.1_3 - 9.6 5.9 12.9 6.7 6.4 9.1 2.4 2 1 0 2 2 2 0 Mnd1 family Dsh_C PF12316.6 MSTRG.14267.1_2 - 0.083 13.2 3.4 0.13 12.6 3.4 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal TFIID_20kDa PF03847.11 MSTRG.14267.1_3 - 1.6e-35 121.2 2.8 2.4e-35 120.7 2.8 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.21 MSTRG.14267.1_3 - 0.00042 20.4 0.1 0.00069 19.7 0.1 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.13 MSTRG.14267.1_3 - 0.00056 19.8 0.0 0.00085 19.3 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Histone PF00125.22 MSTRG.14267.1_3 - 0.0031 17.8 0.1 0.0056 17.0 0.1 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF4 PF05236.12 MSTRG.14267.1_3 - 0.017 14.8 0.0 0.024 14.3 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Myosin_head PF00063.19 MSTRG.1426.3_2 - 1.1e-266 886.3 3.9 1.5e-266 885.8 3.9 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.11 MSTRG.1426.3_2 - 7.3e-29 100.6 2.4 1.5e-27 96.3 0.0 2.8 3 0 0 3 3 3 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.25 MSTRG.1426.3_2 - 3.7e-07 29.2 21.8 0.0019 17.7 0.1 5.3 5 0 0 5 5 5 3 IQ calmodulin-binding motif AAA_16 PF13191.4 MSTRG.1426.3_2 - 0.0031 17.8 0.1 0.014 15.7 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.4 MSTRG.1426.3_2 - 0.019 15.1 0.0 0.091 12.9 0.0 2.2 1 0 0 1 1 1 0 AAA domain Evr1_Alr PF04777.11 MSTRG.1426.3_2 - 0.029 14.8 0.4 1.4 9.4 0.1 3.2 2 1 0 2 2 2 0 Erv1 / Alr family Yqai PF09466.8 MSTRG.1426.3_2 - 0.078 13.2 0.2 0.27 11.4 0.2 1.9 1 1 0 1 1 1 0 Hypothetical protein Yqai Sigma54_activat PF00158.24 MSTRG.1426.3_2 - 0.15 11.6 0.4 0.9 9.1 0.0 2.4 4 0 0 4 4 4 0 Sigma-54 interaction domain Hpr_kinase_C PF07475.10 MSTRG.1426.3_2 - 0.18 11.2 0.8 2.6 7.4 0.0 2.4 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain DUF4441 PF14536.4 MSTRG.1426.3_2 - 2.6 8.2 7.1 10 6.2 1.6 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4441) SRP_TPR_like PF17004.3 MSTRG.8789.1_1 - 0.023 14.6 0.4 0.041 13.8 0.4 1.4 1 0 0 1 1 1 0 Putative TPR-like repeat WH1 PF00568.21 MSTRG.4337.4_3 - 9.8e-37 125.2 0.0 1.6e-36 124.5 0.0 1.3 1 0 0 1 1 1 1 WH1 domain VASP_tetra PF08776.9 MSTRG.4337.4_3 - 8.1e-18 63.6 11.3 1.3e-17 63.0 11.3 1.3 1 0 0 1 1 1 1 VASP tetramerisation domain Ran_BP1 PF00638.16 MSTRG.4337.4_3 - 0.0057 16.8 0.0 0.013 15.7 0.0 1.6 1 0 0 1 1 1 1 RanBP1 domain C2 PF00168.28 MSTRG.15151.2_3 - 1.6e-18 66.8 0.0 2.7e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 C2 domain DUF1241 PF06840.9 MSTRG.8959.1_1 - 3.8e-61 205.0 4.9 5.2e-61 204.6 4.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) FH2 PF02181.21 MSTRG.8959.1_1 - 0.00094 18.3 1.9 0.0014 17.7 1.9 1.2 1 0 0 1 1 1 1 Formin Homology 2 Domain CENP-L PF13092.4 MSTRG.8959.1_1 - 0.013 15.6 0.3 0.019 15.0 0.3 1.2 1 0 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 Focal_AT PF03623.11 MSTRG.8959.1_1 - 0.056 13.2 0.1 0.1 12.4 0.1 1.3 1 0 0 1 1 1 0 Focal adhesion targeting region Med11 PF10280.7 MSTRG.8959.1_1 - 0.074 13.4 0.3 0.15 12.4 0.3 1.5 1 0 0 1 1 1 0 Mediator complex protein GCN5L1 PF06320.11 MSTRG.8959.1_1 - 0.17 11.9 1.2 0.37 10.8 1.0 1.7 1 1 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) Syntaxin_2 PF14523.4 MSTRG.8959.1_1 - 0.46 10.7 4.6 0.64 10.3 3.9 1.6 1 1 0 1 1 1 0 Syntaxin-like protein TAFII55_N PF04658.11 MSTRG.3380.1_1 - 2.2e-58 196.4 0.5 2.2e-58 196.4 0.5 2.0 2 0 0 2 2 2 1 TAFII55 protein conserved region PHR PF08005.10 MSTRG.22873.1_1 - 2.3e-81 271.7 0.0 6.3e-40 137.1 0.0 3.0 2 0 0 2 2 2 2 PHR domain RCC1 PF00415.16 MSTRG.22873.1_1 - 1.4e-23 83.1 16.7 1.8e-12 47.5 1.2 6.6 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 MSTRG.22873.1_1 - 1.2e-22 79.0 14.1 8.4e-08 31.7 0.1 5.8 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat SH3_3 PF08239.9 MSTRG.22873.1_1 - 7.2e-14 51.7 0.4 1.1e-06 28.7 0.0 3.7 3 0 0 3 3 3 2 Bacterial SH3 domain zf-RING_2 PF13639.4 MSTRG.22873.1_1 - 5.1e-08 32.9 3.7 5.1e-08 32.9 3.7 5.1 6 0 0 6 6 6 1 Ring finger domain Filamin PF00630.17 MSTRG.22873.1_1 - 1e-06 29.4 0.1 1.3e-05 25.8 0.0 2.7 2 0 0 2 2 2 1 Filamin/ABP280 repeat ANAPC10 PF03256.14 MSTRG.22873.1_1 - 3.5e-05 23.4 0.1 7.3e-05 22.4 0.1 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) zf-RING_11 PF17123.3 MSTRG.22873.1_1 - 0.00054 19.5 4.0 0.0053 16.3 4.0 2.9 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.5 MSTRG.22873.1_1 - 0.0023 18.0 7.1 0.0041 17.2 3.5 3.5 2 0 0 2 2 2 1 RING-H2 zinc finger domain Integrin_b_cyt PF08725.9 MSTRG.8544.1_2 - 9.8e-29 98.6 5.3 6.6e-22 76.8 1.3 2.3 2 0 0 2 2 2 2 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.10 MSTRG.8544.1_2 - 1.3e-20 73.6 8.8 1.3e-20 73.6 8.8 2.4 3 0 0 3 3 3 1 Integrin beta tail domain EGF_2 PF07974.11 MSTRG.8544.1_2 - 4.1e-06 26.9 14.4 4.1e-06 26.9 14.4 4.7 4 1 0 4 4 4 2 EGF-like domain DUF2975 PF11188.6 MSTRG.8544.1_2 - 0.13 12.0 0.0 0.13 12.0 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2975) PRY PF13765.4 MSTRG.28180.1_3 - 7.7e-08 31.7 0.0 1.9e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 SPRY-associated domain ZU5 PF00791.18 MSTRG.5832.5_1 - 6.9e-33 112.8 0.0 1.8e-32 111.4 0.0 1.7 1 0 0 1 1 1 1 ZU5 domain bZIP_1 PF00170.19 MSTRG.6716.2_2 - 2.7e-09 36.9 18.9 4.4e-09 36.2 18.9 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 MSTRG.6716.2_2 - 6.1e-05 22.9 19.6 0.00011 22.1 19.6 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 MSTRG.6716.2_2 - 0.00018 21.8 11.3 0.00018 21.8 11.3 1.6 2 0 0 2 2 2 1 bZIP Maf transcription factor DUF972 PF06156.11 MSTRG.6716.2_2 - 0.0027 18.2 1.2 0.0048 17.4 1.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF972) CENP-H PF05837.10 MSTRG.6716.2_2 - 0.017 15.4 4.7 0.031 14.5 4.7 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) MCU PF04678.11 MSTRG.6716.2_2 - 0.12 12.4 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter ATP-synt_B PF00430.16 MSTRG.6716.2_2 - 0.64 10.0 6.8 1.2 9.1 6.8 1.3 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) DivIC PF04977.13 MSTRG.6716.2_2 - 4.4 7.0 8.5 5.5 6.7 7.7 1.5 1 1 0 1 1 1 0 Septum formation initiator RGS PF00615.17 MSTRG.12716.2_3 - 1.1e-34 119.1 0.3 1.5e-34 118.7 0.3 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain HTH_Tnp_Tc3_2 PF01498.16 MSTRG.19077.1_1 - 2.1e-10 40.6 2.8 4.4e-10 39.5 2.8 1.5 1 0 0 1 1 1 1 Transposase RRM_1 PF00076.20 MSTRG.19077.1_2 - 1.3e-08 34.4 0.0 2.6e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DDE_3 PF13358.4 MSTRG.19077.1_3 - 0.055 13.1 0.1 0.1 12.3 0.1 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease RRM_1 PF00076.20 MSTRG.11413.2_1 - 5.8e-39 131.6 0.3 8.6e-15 54.2 0.0 4.2 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.11413.2_1 - 7.5e-05 22.6 0.1 0.13 12.2 0.0 3.0 3 0 0 3 3 3 2 RNA recognition motif RRM_5 PF13893.4 MSTRG.11413.2_1 - 9.6e-05 21.8 0.0 0.013 15.0 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.6 MSTRG.11413.2_1 - 0.0011 18.9 0.0 0.019 14.9 0.0 2.6 3 0 0 3 3 3 1 Limkain b1 ERp29 PF07749.10 MSTRG.11413.2_1 - 0.1 13.4 0.0 0.23 12.3 0.0 1.5 1 0 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain Nup35_RRM_2 PF14605.4 MSTRG.11413.2_1 - 0.42 10.5 1.8 6.7 6.6 0.0 2.8 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif DDE_Tnp_4 PF13359.4 MSTRG.12318.2_1 - 0.06 12.9 0.0 0.19 11.2 0.0 1.7 2 0 0 2 2 2 0 DDE superfamily endonuclease Toxin_1 PF00087.19 MSTRG.15614.1_1 - 0.35 11.0 15.0 0.15 12.2 11.6 2.0 2 0 0 2 2 2 0 Snake toxin RRM_1 PF00076.20 MSTRG.7430.4_1 - 1.7e-29 101.3 0.0 5.1e-12 45.3 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF PF08080.10 MSTRG.7430.4_1 - 1.9e-06 27.6 6.8 5.5e-06 26.1 6.8 1.8 1 0 0 1 1 1 1 RNPHF zinc finger PH PF00169.27 MSTRG.27592.4_3 - 1.3e-21 77.0 1.3 2.6e-21 76.0 0.2 2.1 2 0 0 2 2 2 1 PH domain PH_11 PF15413.4 MSTRG.27592.4_3 - 0.00033 20.9 2.2 0.00033 20.9 2.2 2.4 2 1 0 2 2 2 1 Pleckstrin homology domain PH_13 PF16652.3 MSTRG.27592.4_3 - 0.11 12.2 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain Phage_TAC_5 PF08890.9 MSTRG.27592.4_3 - 0.18 11.7 0.1 0.84 9.6 0.0 2.0 2 0 0 2 2 2 0 Phage XkdN-like tail assembly chaperone protein, TAC CIDE-N PF02017.13 MSTRG.25942.1_2 - 1.8e-24 85.4 0.0 3.2e-24 84.6 0.0 1.5 1 0 0 1 1 1 1 CIDE-N domain DCP1 PF06058.11 MSTRG.9338.2_3 - 5.6e-34 116.4 0.1 8e-34 115.9 0.1 1.1 1 0 0 1 1 1 1 Dcp1-like decapping family Orai-1 PF07856.10 MSTRG.8686.1_1 - 9e-69 230.6 6.3 1.6e-68 229.7 6.3 1.4 1 0 0 1 1 1 1 Mediator of CRAC channel activity DUF456 PF04306.11 MSTRG.8686.1_1 - 0.014 15.6 0.4 0.014 15.6 0.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF456) SOUL PF04832.10 MSTRG.14603.3_2 - 8.4e-16 58.4 0.1 1.3e-15 57.8 0.1 1.2 1 0 0 1 1 1 1 SOUL heme-binding protein EF-hand_7 PF13499.4 MSTRG.28219.1_3 - 5.2e-09 36.3 0.4 3.5e-08 33.7 0.4 2.1 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.28219.1_3 - 1.6e-05 24.0 0.0 3e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.30 MSTRG.28219.1_3 - 0.00019 20.6 0.3 0.0035 16.6 0.1 2.3 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 MSTRG.28219.1_3 - 0.00027 20.5 0.0 0.00094 18.8 0.0 1.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.4 MSTRG.28219.1_3 - 0.08 12.6 0.1 0.24 11.1 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain pair Ank_2 PF12796.5 MSTRG.1463.2_3 - 2.8e-24 85.4 6.0 1.6e-17 63.8 0.4 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.1463.2_3 - 7.5e-16 57.9 0.5 1.9e-10 40.7 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 MSTRG.1463.2_3 - 5.4e-14 52.2 1.6 3.7e-05 24.0 0.0 3.9 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.1463.2_3 - 7.7e-13 47.3 0.1 9.6e-06 25.5 0.0 4.2 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.28 MSTRG.1463.2_3 - 6.4e-10 38.9 5.3 1.3e-05 25.3 0.0 4.6 5 0 0 5 5 5 2 Ankyrin repeat Arylesterase PF01731.18 MSTRG.9097.1_3 - 8.2e-28 96.3 1.7 9.6e-28 96.1 0.6 1.7 2 0 0 2 2 2 1 Arylesterase SGL PF08450.10 MSTRG.9097.1_3 - 5.2e-07 29.4 0.0 8e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region Str_synth PF03088.14 MSTRG.9097.1_3 - 6.5e-05 22.9 0.0 0.00016 21.6 0.0 1.6 1 0 0 1 1 1 1 Strictosidine synthase adh_short PF00106.23 MSTRG.13004.1_3 - 7e-40 136.4 0.0 9.4e-40 136.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 MSTRG.13004.1_3 - 2e-27 96.1 0.0 3e-27 95.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 MSTRG.13004.1_3 - 8.4e-15 55.0 0.1 1.3e-14 54.4 0.1 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.13 MSTRG.13004.1_3 - 4.6e-06 25.8 0.1 6.8e-06 25.3 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.19 MSTRG.13004.1_3 - 0.0027 17.1 0.1 0.0036 16.7 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.18 MSTRG.13004.1_3 - 0.0049 16.8 0.0 0.0084 16.0 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase GRDA PF04723.12 MSTRG.13004.1_3 - 0.033 13.8 0.1 0.056 13.1 0.1 1.4 1 0 0 1 1 1 0 Glycine reductase complex selenoprotein A Mem_trans PF03547.16 MSTRG.25416.1_2 - 1.7e-20 72.7 17.4 3.9e-13 48.4 3.4 2.3 1 1 0 2 2 2 2 Membrane transport protein Adeno_E3_CR2 PF02439.13 MSTRG.5302.1_2 - 0.011 15.4 0.1 0.024 14.3 0.1 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Kazal_2 PF07648.13 MSTRG.21997.1_1 - 3.9e-05 23.6 0.2 9.8e-05 22.3 0.0 1.8 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 MSTRG.21997.1_1 - 4.5e-05 23.3 0.6 0.00042 20.2 0.1 2.1 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kelch_1 PF01344.23 MSTRG.45.2_2 - 1.7e-69 229.0 20.7 5.1e-15 54.7 0.6 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 MSTRG.45.2_2 - 4.2e-37 125.1 5.3 9.1e-07 28.8 0.1 6.5 2 1 4 6 6 6 6 Kelch motif BACK PF07707.13 MSTRG.45.2_2 - 4.4e-29 100.5 1.6 7.1e-29 99.8 0.2 2.1 3 0 0 3 3 3 1 BTB And C-terminal Kelch Kelch_3 PF13415.4 MSTRG.45.2_2 - 2.4e-25 88.1 9.5 0.0008 19.5 0.0 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_4 PF13418.4 MSTRG.45.2_2 - 3.6e-25 87.5 3.6 0.00032 20.5 0.1 6.4 3 2 3 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.13 MSTRG.45.2_2 - 4.3e-25 86.6 10.7 0.00012 21.7 0.1 6.6 6 0 0 6 6 6 6 Kelch motif BTB PF00651.29 MSTRG.45.2_2 - 1e-23 83.6 1.4 1e-23 83.6 1.4 1.6 2 0 0 2 2 2 1 BTB/POZ domain Kelch_5 PF13854.4 MSTRG.45.2_2 - 1.6e-06 27.8 4.5 0.034 14.0 0.0 5.0 5 0 0 5 5 5 2 Kelch motif HCO3_cotransp PF00955.19 MSTRG.11184.1_2 - 2.9e-228 758.7 4.1 4.4e-228 758.1 4.1 1.3 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 MSTRG.11184.1_2 - 2.4e-100 335.7 0.1 5e-100 334.6 0.1 1.6 1 0 0 1 1 1 1 Band 3 cytoplasmic domain PTS_EIIA_2 PF00359.20 MSTRG.11184.1_2 - 0.00046 20.0 0.0 0.011 15.5 0.0 2.3 2 0 0 2 2 2 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 Xan_ur_permease PF00860.18 MSTRG.11184.1_2 - 0.13 10.8 14.9 0.22 10.1 1.7 2.9 3 0 0 3 3 3 0 Permease family Fmp27_WPPW PF10359.7 MSTRG.11184.1_2 - 1.3 7.7 5.8 0.11 11.2 0.1 1.8 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain PepSY_2 PF13670.4 MSTRG.15042.2_1 - 2.2 8.2 6.3 3.9 7.4 6.3 1.3 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain DnaJ PF00226.29 MSTRG.15042.2_3 - 1.4e-27 95.5 2.0 2.6e-27 94.6 2.0 1.5 1 0 0 1 1 1 1 DnaJ domain Transketolase_N PF00456.19 MSTRG.9337.1_2 - 5e-44 150.5 0.0 9.6e-44 149.5 0.0 1.4 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.22 MSTRG.9337.1_2 - 1e-39 135.9 0.2 2.1e-39 134.9 0.0 1.6 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.18 MSTRG.9337.1_2 - 2e-30 105.1 0.1 3.8e-30 104.2 0.1 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.4 MSTRG.9337.1_2 - 4.4e-08 32.5 0.0 1.1e-06 27.9 0.0 2.4 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.18 MSTRG.9337.1_2 - 3e-07 29.6 0.0 4.7e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.19 MSTRG.9337.1_2 - 0.00021 21.0 0.1 0.0026 17.4 0.0 2.8 2 2 1 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain XFP_N PF09364.8 MSTRG.9337.1_2 - 0.0018 17.0 0.0 0.0031 16.2 0.0 1.3 1 0 0 1 1 1 1 XFP N-terminal domain DUF3992 PF13157.4 MSTRG.9337.1_2 - 0.035 14.7 0.0 0.075 13.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3992) adh_short PF00106.23 MSTRG.8489.1_2 - 1.4e-42 145.3 0.0 1.9e-42 144.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 MSTRG.8489.1_2 - 7.3e-27 94.3 0.0 1e-26 93.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 MSTRG.8489.1_2 - 6.7e-11 42.3 0.0 1e-10 41.7 0.0 1.2 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.6 MSTRG.8489.1_2 - 0.0039 16.8 0.0 0.0086 15.7 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Epimerase PF01370.19 MSTRG.8489.1_2 - 0.011 15.1 0.0 0.036 13.4 0.0 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Connexin PF00029.17 MSTRG.10844.1_1 - 2.9e-46 157.9 0.0 4.4e-46 157.3 0.0 1.2 1 0 0 1 1 1 1 Connexin Connexin PF00029.17 MSTRG.10844.1_2 - 6.4e-05 22.7 0.7 0.00011 22.0 0.7 1.3 1 0 0 1 1 1 1 Connexin Connexin PF00029.17 MSTRG.10844.1_3 - 4.5e-07 29.7 0.0 6.4e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Connexin BAR_3_WASP_bdg PF10456.7 MSTRG.8328.3_3 - 1.7e-117 390.8 3.8 2.3e-117 390.4 3.8 1.1 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein PX PF00787.22 MSTRG.8328.3_3 - 4.9e-21 74.7 0.1 9.7e-21 73.7 0.1 1.5 1 0 0 1 1 1 1 PX domain SH3_1 PF00018.26 MSTRG.8328.3_3 - 3.3e-09 36.1 0.2 1.6e-08 33.8 0.0 2.2 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 MSTRG.8328.3_3 - 3.4e-08 32.9 0.0 7.7e-08 31.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 MSTRG.8328.3_3 - 1.7e-07 30.8 0.0 8.3e-07 28.6 0.0 2.3 2 0 0 2 2 2 1 Variant SH3 domain Vps5 PF09325.8 MSTRG.8328.3_3 - 0.0002 20.8 0.6 0.12 11.8 0.2 2.2 1 1 0 2 2 2 2 Vps5 C terminal like Pkinase PF00069.23 MSTRG.18585.1_1 - 3e-68 229.9 0.0 4.2e-68 229.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.18585.1_1 - 2.7e-34 118.5 0.0 4.3e-34 117.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 MSTRG.18585.1_1 - 0.0068 16.2 0.1 0.011 15.5 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Rap_GAP PF02145.13 MSTRG.3262.2_2 - 0.00016 21.2 0.0 0.077 12.4 0.0 3.1 4 0 0 4 4 4 2 Rap/ran-GAP C2 PF00168.28 MSTRG.13181.1_3 - 1.6e-16 60.4 0.0 2.5e-16 59.7 0.0 1.3 1 0 0 1 1 1 1 C2 domain LRR_4 PF12799.5 MSTRG.5195.5_2 - 1e-17 63.7 17.7 4.6e-06 26.7 0.5 4.3 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 MSTRG.5195.5_2 - 2.5e-13 49.8 3.4 9.9e-06 25.0 0.0 2.9 2 1 0 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.4 MSTRG.5195.5_2 - 3.1e-11 42.7 18.4 4.1e-05 23.1 4.4 4.0 2 1 1 3 3 3 3 Leucine rich repeat LRR_1 PF00560.31 MSTRG.5195.5_2 - 4.7e-05 23.1 16.5 1.4 9.6 0.2 6.6 6 1 0 6 6 6 3 Leucine Rich Repeat LRR_6 PF13516.4 MSTRG.5195.5_2 - 0.0098 15.7 19.7 0.6 10.2 0.4 5.5 6 0 0 6 6 6 3 Leucine Rich repeat Kelch_1 PF01344.23 MSTRG.12292.1_3 - 3.3e-40 135.3 5.1 3.6e-11 42.3 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 MSTRG.12292.1_3 - 8.1e-22 76.6 4.9 5.7e-08 32.6 0.0 6.1 3 2 3 6 6 6 3 Kelch motif Kelch_2 PF07646.13 MSTRG.12292.1_3 - 1.6e-18 65.8 3.1 5.6e-06 26.0 0.0 6.0 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.4 MSTRG.12292.1_3 - 1.4e-15 56.8 5.8 1.2e-08 34.6 0.0 5.4 6 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.4 MSTRG.12292.1_3 - 2.7e-11 43.0 0.2 0.06 13.2 0.0 4.8 4 0 0 4 4 4 4 Kelch motif Kelch_3 PF13415.4 MSTRG.12292.1_3 - 3.8e-09 36.5 1.4 0.0084 16.2 0.0 6.2 6 0 0 6 6 6 2 Galactose oxidase, central domain zf-H2C2_2 PF13465.4 MSTRG.16128.1_1 - 1.3e-61 202.3 56.4 1.1e-08 35.0 0.7 9.6 9 0 0 9 9 9 9 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.16128.1_1 - 9.4e-34 113.9 69.9 2.8e-05 24.2 1.8 9.8 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.16128.1_1 - 6.8e-31 104.1 63.5 0.00036 21.0 1.1 10.0 9 0 0 9 9 9 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.16128.1_1 - 7.9e-27 92.8 28.2 0.0052 16.9 0.1 9.5 9 0 0 9 9 9 8 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.16128.1_1 - 1.9e-15 56.5 59.8 0.0023 18.1 1.2 9.6 9 0 0 9 9 9 8 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 MSTRG.16128.1_1 - 9.3e-15 54.0 50.2 0.00019 21.2 0.2 10.0 9 1 0 9 9 9 6 C2H2-type zinc finger zf-H2C2_5 PF13909.4 MSTRG.16128.1_1 - 1.9e-08 33.7 41.7 0.00044 19.8 2.8 8.5 8 0 0 8 8 8 5 C2H2-type zinc-finger domain zf-Di19 PF05605.10 MSTRG.16128.1_1 - 5.2e-07 29.7 34.0 0.036 14.2 2.8 5.9 2 1 3 6 6 6 6 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.5 MSTRG.16128.1_1 - 0.0031 17.7 39.7 1.8 8.8 0.4 8.5 1 1 6 7 7 7 1 C2H2 type zinc-finger (2 copies) LIM PF00412.20 MSTRG.16128.1_1 - 0.081 13.0 35.0 4.1 7.6 3.3 7.0 2 2 6 8 8 8 0 LIM domain zf-C2H2_11 PF16622.3 MSTRG.16128.1_1 - 2.1 8.0 39.5 0.23 11.1 0.3 7.2 7 0 0 7 7 7 0 zinc-finger C2H2-type BolA PF01722.16 MSTRG.16128.1_1 - 2.9 8.1 18.1 3.2 8.0 0.3 5.5 2 1 2 5 5 5 0 BolA-like protein MACPF PF01823.17 MSTRG.14413.1_2 - 1.7e-06 28.2 0.1 5.4e-06 26.5 0.0 1.8 2 0 0 2 2 2 1 MAC/Perforin domain PA26 PF04636.11 MSTRG.2826.2_1 - 6.8e-188 624.9 0.0 8.2e-188 624.6 0.0 1.1 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) CMD PF02627.18 MSTRG.2826.2_1 - 0.0023 17.8 0.0 0.0054 16.6 0.0 1.6 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family LRV PF01816.15 MSTRG.2826.2_1 - 2.6 8.5 5.5 1.2 9.6 1.2 2.8 2 0 0 2 2 2 0 Leucine rich repeat variant Cystatin PF00031.19 MSTRG.24335.1_2 - 3.5e-06 27.1 0.0 5.4e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Cystatin domain Lactococcin PF04369.11 MSTRG.24335.1_2 - 0.015 15.3 0.0 0.029 14.4 0.0 1.4 1 0 0 1 1 1 0 Lactococcin-like family Cathelicidins PF00666.15 MSTRG.24335.1_2 - 0.054 13.7 0.0 0.097 12.9 0.0 1.4 1 0 0 1 1 1 0 Cathelicidin HAT_KAT11 PF08214.9 MSTRG.18898.2_2 - 6.6e-67 226.1 0.3 1.4e-66 225.1 0.3 1.5 1 0 0 1 1 1 1 Histone acetylation protein Creb_binding PF09030.8 MSTRG.18898.2_2 - 1.8e-39 134.6 24.6 1.8e-39 134.6 24.6 11.9 5 2 5 12 12 12 1 Creb binding KIX PF02172.14 MSTRG.18898.2_2 - 2.7e-39 133.2 0.7 5.9e-39 132.1 0.7 1.6 1 0 0 1 1 1 1 KIX domain zf-TAZ PF02135.14 MSTRG.18898.2_2 - 7.2e-27 93.5 57.1 8.2e-19 67.7 20.6 3.8 3 0 0 3 3 3 2 TAZ zinc finger DUF902 PF06001.11 MSTRG.18898.2_2 - 3.9e-19 68.7 9.1 3.9e-19 68.7 9.1 2.7 2 0 0 2 2 2 1 Domain of Unknown Function (DUF902) Bromodomain PF00439.23 MSTRG.18898.2_2 - 2.5e-17 62.6 0.1 5.5e-17 61.5 0.1 1.6 1 0 0 1 1 1 1 Bromodomain ZZ PF00569.15 MSTRG.18898.2_2 - 5.3e-15 54.8 12.6 5.3e-15 54.8 12.6 3.6 4 0 0 4 4 4 1 Zinc finger, ZZ type KIX_2 PF16987.3 MSTRG.18898.2_2 - 0.00027 20.7 0.2 0.00027 20.7 0.2 2.8 2 0 0 2 2 2 1 KIX domain Npa1 PF11707.6 MSTRG.18898.2_2 - 0.00089 18.6 0.0 0.0015 17.9 0.0 1.3 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal G-alpha PF00503.18 MSTRG.15217.1_1 - 4.1e-123 410.9 1.1 4.9e-123 410.6 1.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 MSTRG.15217.1_1 - 3.6e-17 62.2 0.3 1e-12 47.7 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 MSTRG.15217.1_1 - 0.00018 20.8 1.7 0.026 13.8 0.5 2.2 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.11 MSTRG.15217.1_1 - 0.00074 19.6 0.2 1.5 9.0 0.1 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 MSTRG.15217.1_1 - 0.12 12.6 0.0 0.28 11.4 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain RhoGEF PF00621.18 MSTRG.7597.1_1 - 8.1e-25 88.0 0.0 8.8e-25 87.9 0.0 1.0 1 0 0 1 1 1 1 RhoGEF domain Kelch_1 PF01344.23 MSTRG.15816.1_1 - 4.2e-32 109.3 13.6 2.6e-12 46.0 0.2 3.7 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.4 MSTRG.15816.1_1 - 5.9e-24 83.4 2.3 2e-09 37.3 0.1 3.3 1 1 2 3 3 3 3 Kelch motif Kelch_4 PF13418.4 MSTRG.15816.1_1 - 2.4e-16 59.3 1.9 1.4e-05 24.8 0.1 3.3 2 1 1 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.4 MSTRG.15816.1_1 - 9.2e-12 44.8 3.4 0.00094 19.3 0.2 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.13 MSTRG.15816.1_1 - 8.6e-09 34.9 4.8 0.0017 18.1 0.0 3.7 3 1 0 3 3 3 3 Kelch motif Kelch_5 PF13854.4 MSTRG.15816.1_1 - 0.066 13.1 2.8 0.83 9.6 0.2 3.1 3 0 0 3 3 3 0 Kelch motif ATP-gua_Ptrans PF00217.17 MSTRG.28655.1_1 - 3.8e-30 105.2 0.0 4e-30 105.1 0.0 1.0 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain SelP_N PF04592.12 MSTRG.13080.1_3 - 0.0026 17.0 7.0 0.0039 16.5 7.0 1.2 1 0 0 1 1 1 1 Selenoprotein P, N terminal region Neur_chan_LBD PF02931.21 MSTRG.9721.1_2 - 1.7e-48 164.8 1.1 2.3e-48 164.4 1.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 MSTRG.9721.1_2 - 4.7e-32 111.8 8.3 6.6e-32 111.3 8.3 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF2070 PF09843.7 MSTRG.9721.1_2 - 2 6.5 6.2 2.7 6.0 6.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) PAN_3 PF08277.10 MSTRG.13019.1_1 - 0.051 13.2 0.1 0.079 12.6 0.1 1.3 1 0 0 1 1 1 0 PAN-like domain Guanylate_kin PF00625.19 MSTRG.11585.1_1 - 4.8e-60 202.2 0.2 1.3e-59 200.8 0.1 1.7 2 0 0 2 2 2 1 Guanylate kinase PDZ PF00595.22 MSTRG.11585.1_1 - 1.3e-17 63.8 0.9 2.5e-17 62.8 0.9 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) L27 PF02828.14 MSTRG.11585.1_1 - 1.9e-14 53.0 0.7 1.8e-12 46.7 0.8 3.4 3 0 0 3 3 3 1 L27 domain SH3_2 PF07653.15 MSTRG.11585.1_1 - 4.6e-13 48.5 0.0 9.4e-13 47.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.11585.1_1 - 1e-08 34.5 0.1 2.9e-08 33.0 0.1 1.9 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.11585.1_1 - 6.9e-05 22.5 0.0 0.00019 21.1 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain PDZ_2 PF13180.4 MSTRG.11585.1_1 - 0.00076 19.6 0.0 0.002 18.3 0.0 1.6 1 0 0 1 1 1 1 PDZ domain RasGEF PF00617.17 MSTRG.5325.1_1 - 2.9e-42 144.7 0.1 5.2e-42 143.8 0.1 1.4 1 0 0 1 1 1 1 RasGEF domain PMP22_Claudin PF00822.18 MSTRG.10042.1_2 - 5.2e-32 110.9 16.9 6.9e-32 110.5 16.9 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 MSTRG.10042.1_2 - 9.4e-14 51.5 19.3 1.6e-07 31.1 15.8 2.3 1 1 1 2 2 2 2 PMP-22/EMP/MP20/Claudin tight junction DUF4064 PF13273.4 MSTRG.10042.1_2 - 0.0037 17.5 7.0 4.8 7.5 0.0 3.0 2 1 1 3 3 3 2 Protein of unknown function (DUF4064) AWPM-19 PF05512.9 MSTRG.10042.1_2 - 0.0067 16.5 0.6 0.011 15.8 0.6 1.5 1 0 0 1 1 1 1 AWPM-19-like family SUR7 PF06687.10 MSTRG.10042.1_2 - 0.011 15.2 14.1 0.011 15.2 14.1 2.1 1 1 1 2 2 2 0 SUR7/PalI family DUF373 PF04123.11 MSTRG.10042.1_2 - 0.026 13.9 3.8 0.022 14.1 2.8 1.3 2 0 0 2 2 2 0 Domain of unknown function (DUF373) DUF4231 PF14015.4 MSTRG.10042.1_2 - 0.72 10.2 5.2 43 4.5 0.0 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) TMEM174 PF15029.4 MSTRG.10042.1_2 - 0.93 9.0 7.7 1.1 8.8 3.2 2.1 1 1 1 2 2 2 0 Transmembrane protein 174 VIT1 PF01988.17 MSTRG.10042.1_2 - 3.1 7.5 7.6 4.6 6.9 7.6 1.2 1 0 0 1 1 1 0 VIT family MgtE PF01769.14 MSTRG.10042.1_2 - 5.5 7.2 13.8 15 5.8 12.8 2.1 1 1 0 1 1 1 0 Divalent cation transporter DUF2070 PF09843.7 MSTRG.10042.1_2 - 5.7 5.0 7.0 8 4.5 7.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) CD36 PF01130.19 MSTRG.19646.12_3 - 3.3e-54 184.0 0.0 4.2e-54 183.7 0.0 1.1 1 0 0 1 1 1 1 CD36 family RRM_1 PF00076.20 MSTRG.17635.2_2 - 0.0065 16.1 0.0 0.0096 15.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2457 PF10446.7 MSTRG.17635.2_2 - 0.68 8.9 10.7 0.79 8.7 10.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NHL PF01436.19 MSTRG.27487.1_2 - 1.3e-44 147.9 27.2 7.1e-09 35.1 0.5 6.9 7 0 0 7 7 7 6 NHL repeat DUF5128 PF17170.2 MSTRG.27487.1_2 - 5.9e-16 58.4 8.5 7.1e-07 28.5 0.7 4.1 2 2 1 3 3 3 3 6-bladed beta-propeller Filamin PF00630.17 MSTRG.27487.1_2 - 6.7e-15 55.6 0.0 1.7e-14 54.4 0.0 1.7 1 0 0 1 1 1 1 Filamin/ABP280 repeat SGL PF08450.10 MSTRG.27487.1_2 - 2.2e-08 33.8 3.2 0.0011 18.5 0.1 4.9 1 1 4 5 5 5 2 SMP-30/Gluconolaconase/LRE-like region DUF4934 PF16288.3 MSTRG.27487.1_2 - 9e-05 22.2 1.3 0.059 13.2 0.4 3.0 2 1 1 3 3 3 3 Domain of unknown function (DUF4934) VCBS PF13517.4 MSTRG.27487.1_2 - 9.2 6.8 9.8 20 5.7 0.1 4.0 2 1 2 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Alpha_kinase PF02816.16 MSTRG.3297.1_3 - 9e-36 123.7 0.0 1.5e-35 123.0 0.0 1.4 1 0 0 1 1 1 1 Alpha-kinase family RGS12_us1 PF16613.3 MSTRG.18988.3_3 - 1.3e-48 164.0 12.1 1.3e-48 164.0 12.1 3.0 3 0 0 3 3 3 1 Unstructured region of RGS12 RGS PF00615.17 MSTRG.18988.3_3 - 2.8e-27 95.2 4.8 4.7e-27 94.5 4.8 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain RBD PF02196.13 MSTRG.18988.3_3 - 5.5e-26 90.3 0.4 3e-16 59.1 0.1 2.6 2 0 0 2 2 2 2 Raf-like Ras-binding domain GoLoco PF02188.15 MSTRG.18988.3_3 - 8.5e-09 34.6 0.1 1.8e-08 33.6 0.1 1.6 1 0 0 1 1 1 1 GoLoco motif RGS12_usC PF16612.3 MSTRG.18988.3_3 - 2.4e-08 34.4 0.6 2.4e-08 34.4 0.6 3.5 4 0 0 4 4 4 1 C-terminal unstructured region of RGS12 RGS12_us2 PF16611.3 MSTRG.18988.3_3 - 0.00013 22.2 1.3 0.00013 22.2 1.3 2.2 2 0 0 2 2 2 1 Unstructured region between RBD and GoLoco TUG-UBL1 PF11470.6 MSTRG.18988.3_3 - 0.065 13.4 0.0 0.26 11.5 0.0 2.0 1 0 0 1 1 1 0 TUG ubiquitin-like domain DUF4613 PF15390.4 MSTRG.24737.1_1 - 4e-288 957.4 0.0 4.5e-288 957.2 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4613) ANAPC4_WD40 PF12894.5 MSTRG.24737.1_1 - 0.087 13.0 0.1 0.23 11.7 0.1 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.10 MSTRG.24737.1_1 - 0.09 12.6 0.0 0.28 11.1 0.0 1.9 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat APC_15aa PF05972.9 MSTRG.25463.1_3 - 0.11 12.7 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 APC 15 residue motif Med30 PF11315.6 MSTRG.7935.4_1 - 2.5e-35 121.8 0.0 3.7e-35 121.2 0.0 1.2 1 0 0 1 1 1 1 Mediator complex subunit 30 Med30 PF11315.6 MSTRG.7935.4_3 - 2.2e-19 70.0 0.1 3.8e-19 69.3 0.1 1.4 1 0 0 1 1 1 1 Mediator complex subunit 30 APG17 PF04108.10 MSTRG.7935.4_3 - 0.062 12.3 0.6 0.09 11.7 0.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg17 UPF0449 PF15136.4 MSTRG.7935.4_3 - 0.082 13.3 0.2 0.14 12.5 0.2 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 Peptidase_S64 PF08192.9 MSTRG.7935.4_3 - 0.17 10.2 0.1 0.23 9.8 0.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 PSD2 PF07624.9 MSTRG.7935.4_3 - 0.18 11.4 0.1 0.31 10.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1585) DUF3719 PF12516.6 MSTRG.26470.1_1 - 3.2e-05 23.4 0.0 4.5e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3719) zf-H2C2_2 PF13465.4 MSTRG.4273.3_2 - 1.3e-49 164.3 81.6 3e-09 36.8 0.1 12.4 12 0 0 12 12 12 8 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.4273.3_2 - 9.7e-38 126.4 100.2 8.5e-06 25.8 1.1 12.6 12 0 0 12 12 12 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.4273.3_2 - 2.4e-28 96.2 91.1 0.002 18.7 1.8 12.7 12 0 0 12 12 12 11 C2H2-type zinc finger TINF2_N PF14973.4 MSTRG.4273.3_2 - 1.4e-27 96.8 0.9 1.2e-15 58.0 0.0 2.7 2 0 0 2 2 2 2 TERF1-interacting nuclear factor 2 N-terminus zf-C2H2_6 PF13912.4 MSTRG.4273.3_2 - 2e-09 37.0 88.0 0.042 13.7 0.3 12.4 12 0 0 12 12 12 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.4273.3_2 - 4.8e-09 36.2 60.0 0.25 11.6 0.1 12.1 12 0 0 12 12 12 7 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 MSTRG.4273.3_2 - 0.019 14.9 53.9 0.45 10.6 1.2 8.4 7 3 1 8 8 8 0 Zinc ribbon domain DUF3268 PF11672.6 MSTRG.4273.3_2 - 0.043 14.0 0.7 0.043 14.0 0.7 5.3 2 2 4 7 7 7 0 zinc-finger-containing domain zinc_ribbon_9 PF14369.4 MSTRG.4273.3_2 - 0.81 9.9 0.0 0.81 9.9 0.0 8.7 10 0 0 10 10 10 0 zinc-ribbon NDK PF00334.17 MSTRG.18683.2_2 - 2.1e-53 179.8 0.0 3e-53 179.3 0.0 1.2 1 0 0 1 1 1 1 Nucleoside diphosphate kinase 7tm_2 PF00002.22 MSTRG.10198.1_2 - 4.4e-75 252.0 23.3 6.8e-75 251.4 23.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 MSTRG.10198.1_2 - 3.8e-15 55.8 1.4 8.1e-15 54.7 1.4 1.6 1 0 0 1 1 1 1 Hormone receptor domain Drf_DAD PF06345.9 MSTRG.7257.2_3 - 4.6e-06 26.2 1.9 1.1e-05 25.0 1.9 1.7 1 0 0 1 1 1 1 DRF Autoregulatory Domain FH2 PF02181.21 MSTRG.7257.2_3 - 7.6e-06 25.1 0.2 7.6e-06 25.1 0.2 1.5 2 0 0 2 2 2 1 Formin Homology 2 Domain Pkinase PF00069.23 MSTRG.182.2_1 - 1.5e-89 299.7 0.0 2.2e-46 158.2 0.0 3.4 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.182.2_1 - 6.2e-52 176.3 0.0 1.2e-27 96.7 0.0 3.1 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.182.2_1 - 5.4e-09 35.7 0.0 0.0005 19.4 0.0 3.0 3 0 0 3 3 3 2 Kinase-like PIP49_C PF12260.6 MSTRG.182.2_1 - 2.8e-06 27.0 0.0 0.14 11.7 0.0 3.0 2 0 0 2 2 2 2 Protein-kinase domain of FAM69 APH PF01636.21 MSTRG.182.2_1 - 0.00014 21.7 3.6 0.24 11.1 0.3 2.5 2 0 0 2 2 2 2 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.9 MSTRG.182.2_1 - 0.0018 17.2 0.0 1.6 7.4 0.0 2.1 2 0 0 2 2 2 2 Poxvirus serine/threonine protein kinase Seadorna_VP7 PF07387.9 MSTRG.182.2_1 - 0.014 14.4 1.2 3.4 6.5 0.1 2.2 2 0 0 2 2 2 0 Seadornavirus VP7 PilP PF04351.11 MSTRG.182.2_1 - 0.23 11.2 0.3 34 4.2 0.0 2.5 2 0 0 2 2 2 0 Pilus assembly protein, PilP AZUL PF16558.3 MSTRG.182.2_2 - 1.2 9.3 7.6 13 5.9 0.9 2.8 2 0 0 2 2 2 0 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A Arm PF00514.21 MSTRG.182.2_2 - 9.3 6.3 7.0 3.3e+02 1.4 0.0 4.2 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat zf-RING_11 PF17123.3 MSTRG.15374.1_1 - 0.0076 15.8 0.0 0.018 14.6 0.0 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-CHY PF05495.10 MSTRG.15374.1_2 - 0.014 15.9 4.8 0.031 14.7 4.8 1.5 1 0 0 1 1 1 0 CHY zinc finger LIM PF00412.20 MSTRG.15374.1_2 - 0.054 13.6 2.4 0.054 13.6 2.4 2.4 1 1 1 2 2 2 0 LIM domain Laminin_EGF PF00053.22 MSTRG.15374.1_2 - 8.5 6.5 10.1 22 5.1 7.6 2.7 2 1 0 2 2 2 0 Laminin EGF domain Cyt-b5 PF00173.26 MSTRG.17359.7_3 - 6.9e-24 83.6 0.0 1.1e-23 82.9 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain LIM PF00412.20 MSTRG.15372.1_3 - 8.5e-31 105.8 24.7 7.5e-11 42.0 5.9 3.5 3 0 0 3 3 3 3 LIM domain DUF951 PF06107.9 MSTRG.15372.1_3 - 0.29 10.9 3.3 2.1 8.2 0.0 3.6 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF951) FYVE PF01363.19 MSTRG.17732.1_1 - 1e-16 60.7 8.2 1.5e-16 60.1 8.2 1.3 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.14 MSTRG.17732.1_1 - 0.12 12.5 5.0 0.24 11.5 5.0 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger DZR PF12773.5 MSTRG.17732.1_1 - 0.6 10.0 9.7 7.8 6.5 5.9 2.3 1 1 1 2 2 2 0 Double zinc ribbon NOB1_Zn_bind PF08772.9 MSTRG.17732.1_1 - 3 7.9 8.8 0.32 11.0 4.0 1.8 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like Cyt-b5 PF00173.26 MSTRG.17359.2_1 - 9e-24 83.3 0.0 1.5e-23 82.6 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Amidase PF01425.19 MSTRG.1194.2_2 - 2.1e-113 379.5 1.6 1.2e-72 245.1 2.1 2.4 2 1 0 2 2 2 2 Amidase CLP_protease PF00574.21 MSTRG.24153.1_2 - 2.4e-80 268.6 0.1 3.1e-80 268.2 0.1 1.1 1 0 0 1 1 1 1 Clp protease PID PF00640.21 MSTRG.23435.2_3 - 1.5e-17 63.8 0.5 2.4e-17 63.1 0.5 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PID_2 PF14719.4 MSTRG.23435.2_3 - 6e-17 61.9 0.3 1e-16 61.2 0.3 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 MSTRG.23435.2_3 - 1.2e-08 35.0 0.1 1.8e-08 34.5 0.1 1.2 1 0 0 1 1 1 1 Phosphotyrosine-binding domain Ank_2 PF12796.5 MSTRG.15222.2_1 - 2.5e-08 34.2 0.0 4e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.15222.2_1 - 2e-07 31.3 0.0 0.00055 20.3 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.15222.2_1 - 8e-07 28.8 0.0 2e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeat Ank_5 PF13857.4 MSTRG.15222.2_1 - 0.0019 18.4 0.0 0.0044 17.2 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.15222.2_1 - 0.0028 17.9 0.0 0.0073 16.6 0.0 1.7 2 0 0 2 2 2 1 Ankyrin repeat EF-hand_1 PF00036.30 MSTRG.2416.1_3 - 9e-19 65.4 13.9 0.0023 17.2 0.6 6.7 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.4 MSTRG.2416.1_3 - 3.4e-16 59.3 22.2 0.00016 21.9 2.1 4.8 5 0 0 5 5 5 4 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.2416.1_3 - 5.1e-15 53.9 13.1 0.01 15.6 0.0 6.7 6 0 0 6 6 6 6 EF-hand domain EF-hand_5 PF13202.4 MSTRG.2416.1_3 - 1.9e-12 46.0 26.2 0.0093 15.3 0.9 6.7 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.4 MSTRG.2416.1_3 - 1.2e-07 31.2 10.4 0.086 12.5 0.0 4.8 5 0 0 5 5 5 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 MSTRG.2416.1_3 - 0.69 10.1 13.6 1.7 8.9 0.4 3.6 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Endonuclease_7 PF02945.13 MSTRG.17119.2_1 - 1.9 8.3 5.9 0.36 10.6 0.7 2.3 2 0 0 2 2 2 0 Recombination endonuclease VII zf-H2C2_2 PF13465.4 MSTRG.17119.2_2 - 1.5e-86 281.1 76.7 8.8e-08 32.1 0.4 13.8 13 0 0 13 13 13 12 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.17119.2_2 - 2e-52 172.7 106.5 2.1e-06 27.8 1.3 14.0 14 0 0 14 14 13 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.17119.2_2 - 4.9e-43 141.9 100.7 0.00053 20.5 0.8 14.4 14 0 0 14 14 13 13 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.17119.2_2 - 5.3e-16 58.0 82.0 0.0088 15.8 0.4 13.2 12 2 1 13 13 13 10 C2H2-type zinc finger zf-met PF12874.5 MSTRG.17119.2_2 - 1.5e-12 47.3 81.3 0.027 14.7 0.9 13.1 13 0 0 13 13 13 7 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 MSTRG.17119.2_2 - 8e-06 25.4 69.4 0.0012 18.4 1.3 11.6 11 0 0 11 11 11 4 zinc-finger C2H2-type zf-Di19 PF05605.10 MSTRG.17119.2_2 - 2.7e-05 24.2 50.6 0.19 11.9 0.7 8.1 1 1 11 12 12 12 10 Drought induced 19 protein (Di19), zinc-binding BolA PF01722.16 MSTRG.17119.2_2 - 0.0025 17.9 25.2 6 7.1 0.2 7.1 3 2 4 7 7 7 4 BolA-like protein Zn-ribbon_8 PF09723.8 MSTRG.17119.2_2 - 0.0049 16.8 44.4 2.1 8.4 2.6 8.7 4 3 6 10 10 10 4 Zinc ribbon domain zinc_ribbon_15 PF17032.3 MSTRG.17119.2_2 - 0.0094 16.6 43.5 0.53 10.9 0.3 7.7 2 1 7 10 10 9 4 zinc-ribbon family zf-C2H2_jaz PF12171.6 MSTRG.17119.2_2 - 0.12 12.6 53.4 0.21 11.8 0.1 11.0 14 0 0 14 14 13 0 Zinc-finger double-stranded RNA-binding DUF2180 PF09947.7 MSTRG.17119.2_2 - 0.52 10.2 23.2 1.2 9.0 0.7 7.3 3 2 5 8 8 8 0 Uncharacterized protein conserved in archaea (DUF2180) zf-H2C2_5 PF13909.4 MSTRG.17119.2_2 - 1.4 8.6 0.0 0.91 9.2 0.3 12.3 13 1 0 13 13 13 0 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.5 MSTRG.17119.2_2 - 2.2 8.6 52.5 23 5.3 0.5 11.1 1 1 8 10 10 10 0 C2H2 type zinc-finger (2 copies) PPP4R2 PF09184.9 MSTRG.17119.2_2 - 5.7 6.3 7.6 8.2 5.8 7.6 1.1 1 0 0 1 1 1 0 PPP4R2 zf-met PF12874.5 MSTRG.23015.1_2 - 1.5e-16 60.1 33.3 3.4e-08 33.5 0.5 4.3 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.23015.1_2 - 9.8e-16 57.5 12.2 5.8e-05 23.2 1.0 4.0 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding AKAP95 PF04988.10 MSTRG.23015.1_2 - 0.0023 18.0 6.3 0.54 10.3 0.1 3.3 3 0 0 3 3 3 2 A-kinase anchoring protein 95 (AKAP95) zf-U1 PF06220.10 MSTRG.23015.1_2 - 0.0051 16.4 4.5 0.28 10.9 0.0 3.5 3 0 0 3 3 3 1 U1 zinc finger zf-C2H2_2 PF12756.5 MSTRG.23015.1_2 - 0.053 13.7 18.1 1.2 9.4 0.1 3.9 4 0 0 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-DBF PF07535.10 MSTRG.23015.1_2 - 0.42 10.6 8.0 0.22 11.5 0.3 3.3 3 0 0 3 3 3 0 DBF zinc finger zf-C2H2 PF00096.24 MSTRG.23015.1_2 - 1.3 9.5 9.6 30 5.2 1.0 4.0 3 0 0 3 3 3 0 Zinc finger, C2H2 type Tom37 PF10568.7 MSTRG.5685.2_2 - 6.5e-37 126.6 0.1 1.1e-36 125.8 0.1 1.4 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.2 MSTRG.5685.2_2 - 6.3e-21 73.8 0.2 1.4e-20 72.7 0.2 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.2 MSTRG.5685.2_2 - 1.1e-11 45.2 0.0 2.3e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.4 MSTRG.5685.2_2 - 0.0014 18.4 0.0 0.0037 17.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GDA1_CD39 PF01150.15 MSTRG.16915.1_1 - 2.4e-21 75.8 0.0 3.1e-21 75.4 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family GDA1_CD39 PF01150.15 MSTRG.16915.1_2 - 1.5e-47 162.1 0.1 2.1e-47 161.6 0.1 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Adhesin_E PF16747.3 MSTRG.16915.1_2 - 0.1 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Surface-adhesin protein E IRK PF01007.18 MSTRG.2475.1_1 - 1.8e-141 470.8 0.0 2.3e-141 470.4 0.0 1.0 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 MSTRG.2475.1_1 - 0.035 14.0 4.7 0.077 12.8 4.7 1.6 1 1 0 1 1 1 0 Ion channel PP2C PF00481.19 MSTRG.27045.2_3 - 1.1e-48 165.9 0.1 1.3e-48 165.8 0.1 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.4 MSTRG.27045.2_3 - 0.019 14.4 0.0 0.04 13.4 0.0 1.6 1 1 0 1 1 1 0 Protein phosphatase 2C zf-C2H2 PF00096.24 MSTRG.5333.2_1 - 5.1e-50 165.1 202.3 0.00067 19.9 0.9 24.6 24 0 0 24 24 24 23 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.5333.2_1 - 1.5e-37 124.9 188.0 0.0026 18.3 0.6 24.6 24 0 0 24 24 24 18 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.5333.2_1 - 7.1e-17 61.1 122.5 0.054 13.7 0.9 21.5 21 1 1 22 22 22 12 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 MSTRG.5333.2_1 - 6.3e-15 54.6 167.5 8.4e-05 22.3 1.6 20.5 21 0 0 21 21 21 15 C2H2-type zinc finger zf-H2C2_2 PF13465.4 MSTRG.5333.2_1 - 1.4e-06 28.4 164.3 0.0037 17.5 2.8 23.8 25 1 0 25 25 25 11 Zinc-finger double domain zf-met PF12874.5 MSTRG.5333.2_1 - 0.015 15.5 144.6 0.11 12.8 1.0 21.3 21 0 0 21 21 21 0 Zinc-finger of C2H2 type Rad50_zn_hook PF04423.12 MSTRG.5333.2_1 - 0.088 12.5 0.4 2.1 8.1 0.0 2.6 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-C2H2 PF00096.24 MSTRG.5333.2_2 - 2.9e-24 84.0 79.9 4.1e-05 23.7 5.2 9.3 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.5333.2_2 - 3.5e-11 42.9 70.5 3.7e-06 27.0 1.4 9.5 10 0 0 10 10 10 4 Zinc-finger double domain zf-C2H2_6 PF13912.4 MSTRG.5333.2_2 - 7.9e-10 38.3 57.8 0.00059 19.6 1.5 8.6 8 0 0 8 8 8 6 C2H2-type zinc finger zf-C2H2_4 PF13894.4 MSTRG.5333.2_2 - 7.3e-09 35.6 89.0 0.00025 21.5 3.9 9.8 10 0 0 10 10 8 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.5333.2_2 - 0.0021 18.2 42.9 0.3 11.3 1.9 7.7 8 0 0 8 8 8 3 Zinc-finger double-stranded RNA-binding CpXC PF14353.4 MSTRG.5333.2_2 - 0.0029 17.5 22.0 0.32 10.9 0.4 5.9 2 2 4 6 6 6 1 CpXC protein zf-H2C2_5 PF13909.4 MSTRG.5333.2_2 - 0.0063 16.1 4.1 0.0063 16.1 4.1 3.4 3 0 0 3 3 3 1 C2H2-type zinc-finger domain DZR PF12773.5 MSTRG.5333.2_2 - 0.033 14.1 30.1 1.9 8.4 0.9 5.5 3 1 0 3 3 3 0 Double zinc ribbon zinc_ribbon_5 PF13719.4 MSTRG.5333.2_2 - 0.6 9.8 22.2 0.9 9.2 1.6 4.9 5 0 0 5 5 5 0 zinc-ribbon domain C1_4 PF07975.10 MSTRG.5333.2_2 - 0.91 9.7 26.7 0.27 11.4 7.8 4.4 3 2 2 5 5 4 0 TFIIH C1-like domain Zn-ribbon_8 PF09723.8 MSTRG.5333.2_2 - 5.1 7.2 26.2 0.085 12.9 0.9 5.8 5 1 0 6 6 6 0 Zinc ribbon domain RasGEF PF00617.17 MSTRG.3298.1_2 - 1.9e-41 142.0 0.2 3.3e-41 141.2 0.2 1.4 1 0 0 1 1 1 1 RasGEF domain C1_1 PF00130.20 MSTRG.3298.1_2 - 2.5e-13 49.6 10.3 7.9e-13 48.0 10.3 1.9 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_5 PF13202.4 MSTRG.3298.1_2 - 4.5e-13 47.9 3.2 1.9e-06 27.0 0.3 2.6 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.30 MSTRG.3298.1_2 - 4.5e-12 44.5 3.0 8.5e-06 24.8 0.4 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 MSTRG.3298.1_2 - 1.6e-11 43.0 0.7 2.1e-05 24.0 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.4 MSTRG.3298.1_2 - 4.6e-11 42.9 0.3 2.2e-05 24.7 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.4 MSTRG.3298.1_2 - 1.1e-06 28.2 2.6 0.00086 18.9 0.8 2.7 2 0 0 2 2 2 2 EF-hand domain pair RasGEF_N PF00618.18 MSTRG.3298.1_2 - 1.5e-05 25.1 1.1 0.00061 19.9 0.0 3.6 3 2 0 3 3 3 1 RasGEF N-terminal motif SPARC_Ca_bdg PF10591.7 MSTRG.3298.1_2 - 0.0041 17.3 0.1 0.57 10.4 0.1 2.7 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Cpn60_TCP1 PF00118.22 MSTRG.7786.1_1 - 3.2e-86 289.8 0.0 3.7e-86 289.6 0.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family EGF PF00008.25 MSTRG.12030.1_2 - 4.3e-31 106.7 75.1 2e-10 40.6 10.0 5.4 5 0 0 5 5 5 5 EGF-like domain hEGF PF12661.5 MSTRG.12030.1_2 - 2.5e-24 84.9 70.4 2.1e-07 31.2 2.9 7.1 7 0 0 7 7 7 5 Human growth factor-like EGF EGF_CA PF07645.13 MSTRG.12030.1_2 - 3.8e-13 49.3 66.8 2.1e-06 27.7 7.9 5.3 4 1 1 5 5 5 4 Calcium-binding EGF domain EGF_2 PF07974.11 MSTRG.12030.1_2 - 6.5e-11 42.3 69.2 0.0021 18.2 9.8 5.5 4 1 1 5 5 5 4 EGF-like domain cEGF PF12662.5 MSTRG.12030.1_2 - 2.4e-09 36.8 74.6 0.0028 17.4 1.2 7.8 8 1 0 8 8 8 5 Complement Clr-like EGF-like EGF_3 PF12947.5 MSTRG.12030.1_2 - 2e-06 27.8 58.5 0.016 15.2 10.9 6.3 3 2 2 5 5 5 4 EGF domain Laminin_EGF PF00053.22 MSTRG.12030.1_2 - 2.4e-05 24.2 59.2 0.92 9.6 6.5 5.5 2 1 3 5 5 5 3 Laminin EGF domain FXa_inhibition PF14670.4 MSTRG.12030.1_2 - 2.5e-05 24.3 59.4 0.083 13.1 8.9 5.6 2 2 3 5 5 5 3 Coagulation Factor Xa inhibitory site SSI PF00720.15 MSTRG.12030.1_3 - 5 7.0 12.8 0.67 9.8 3.5 2.3 1 1 0 2 2 2 0 Subtilisin inhibitor-like 6PF2K PF01591.16 MSTRG.2619.1_3 - 4.5e-29 101.2 0.0 5.5e-29 100.9 0.0 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_33 PF13671.4 MSTRG.2619.1_3 - 0.008 16.2 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.8 MSTRG.2619.1_3 - 0.018 14.4 0.0 0.023 14.0 0.0 1.1 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Zeta_toxin PF06414.10 MSTRG.2619.1_3 - 0.1 11.8 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin SRP54 PF00448.20 MSTRG.2619.1_3 - 0.23 10.9 0.0 0.3 10.6 0.0 1.1 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain MCU PF04678.11 MSTRG.7736.2_1 - 1.9e-71 239.7 0.8 2.7e-71 239.2 0.8 1.2 1 0 0 1 1 1 1 Mitochondrial calcium uniporter SPX PF03105.17 MSTRG.7736.2_1 - 1 9.1 3.7 0.23 11.2 0.4 1.4 2 0 0 2 2 2 0 SPX domain Ribosomal_L24e PF01246.18 MSTRG.22302.1_2 - 1.6e-33 114.6 0.5 1.6e-33 114.6 0.5 1.8 2 0 0 2 2 2 1 Ribosomal protein L24e Band_3_cyto PF07565.11 MSTRG.22302.1_2 - 0.76 9.4 3.8 0.95 9.1 3.8 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Borrelia_P83 PF05262.9 MSTRG.22302.1_2 - 2.7 6.2 13.1 3.2 6.0 13.1 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Troponin PF00992.18 MSTRG.2675.1_3 - 1.4e-45 154.7 12.1 1.4e-45 154.7 12.1 1.7 1 1 1 2 2 2 1 Troponin Cas_DxTHG PF09455.8 MSTRG.2675.1_3 - 0.028 13.9 2.8 0.035 13.6 2.8 1.2 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family Transposase_22 PF02994.12 MSTRG.2675.1_3 - 0.16 10.7 10.4 0.12 11.1 9.2 1.4 1 1 0 1 1 1 0 L1 transposable element Fumble PF03630.12 MSTRG.29679.1_1 - 1.3e-21 77.0 0.3 1.5e-21 76.8 0.3 1.1 1 0 0 1 1 1 1 Fumble Pkinase PF00069.23 MSTRG.16710.1_2 - 2e-48 164.9 0.2 3e-48 164.3 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.16710.1_2 - 5.5e-31 107.7 0.1 7.9e-31 107.2 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PTEN_C2 PF10409.7 MSTRG.16710.1_2 - 1.4e-28 99.2 0.5 2.9e-28 98.2 0.1 1.7 2 0 0 2 2 2 1 C2 domain of PTEN tumour-suppressor protein DnaJ PF00226.29 MSTRG.16710.1_2 - 5.8e-06 26.2 0.0 1.3e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain Kinase-like PF14531.4 MSTRG.16710.1_2 - 0.0026 17.0 0.1 0.15 11.2 0.0 2.2 2 0 0 2 2 2 1 Kinase-like SWIRM PF04433.15 MSTRG.16710.1_2 - 0.0043 17.2 0.0 0.012 15.8 0.0 1.7 1 0 0 1 1 1 1 SWIRM domain Seadorna_VP7 PF07387.9 MSTRG.16710.1_2 - 0.08 11.8 0.0 0.16 10.9 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 SelP_N PF04592.12 MSTRG.9550.2_1 - 0.39 10.0 4.8 0.6 9.3 4.8 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF2370 PF10176.7 MSTRG.9550.2_3 - 1.2e-05 24.9 14.3 6.2e-05 22.6 2.8 3.3 1 1 2 3 3 3 2 Protein of unknown function (DUF2370) Comm PF15957.3 MSTRG.9550.2_3 - 0.0044 17.2 0.1 0.02 15.1 0.0 2.0 2 0 0 2 2 2 1 Commissureless fn3 PF00041.19 MSTRG.3422.5_1 - 4.1e-37 126.3 3.6 4.3e-13 49.3 0.0 5.3 5 1 0 5 5 5 4 Fibronectin type III domain fn3_2 PF16893.3 MSTRG.3422.5_1 - 7.6e-08 32.3 0.3 0.032 14.2 0.0 4.3 4 0 0 4 4 4 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 MSTRG.3422.5_1 - 3.7e-07 30.5 6.6 0.68 10.4 0.0 4.7 3 2 1 4 4 4 3 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 MSTRG.3422.5_1 - 0.0023 18.1 1.5 3.1 8.0 0.0 4.1 5 0 0 5 5 5 1 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.7 MSTRG.3422.5_1 - 0.036 14.4 0.2 23 5.4 0.0 3.7 4 0 0 4 4 4 0 Uncharacterised conserved protein (DUF2369) NIF PF03031.16 MSTRG.4256.1_1 - 1.3e-52 177.5 0.0 1.8e-52 177.1 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase TRAP-gamma PF07074.10 MSTRG.23098.1_3 - 3 7.2 5.2 0.68 9.3 1.7 1.6 2 0 0 2 2 2 0 Translocon-associated protein, gamma subunit (TRAP-gamma) PhoLip_ATPase_N PF16209.3 MSTRG.21702.2_2 - 4e-27 93.6 3.0 5.6e-27 93.2 3.0 1.2 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.18 MSTRG.21702.2_2 - 0.00018 20.8 0.5 0.00046 19.4 0.1 1.7 1 1 1 2 2 2 1 E1-E2 ATPase zf-C2H2_3 PF13878.4 MSTRG.13974.3_2 - 0.046 13.4 1.0 0.11 12.2 1.0 1.6 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO CDI PF02234.17 MSTRG.13974.3_3 - 1.1e-16 60.7 0.1 1.7e-16 60.0 0.1 1.4 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor ATP-synt_ab PF00006.23 MSTRG.9424.2_2 - 1.3e-103 345.1 0.1 2.7e-93 311.4 0.0 2.2 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.3 MSTRG.9424.2_2 - 1.6e-42 144.1 0.0 2.9e-42 143.2 0.0 1.5 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.21 MSTRG.9424.2_2 - 1.5e-14 54.1 2.5 3.4e-14 53.0 2.5 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain LSM PF01423.20 MSTRG.26579.1_1 - 4.5e-20 71.0 0.2 6e-20 70.6 0.2 1.2 1 0 0 1 1 1 1 LSM domain Lge1 PF11488.6 MSTRG.21592.1_1 - 0.00017 22.0 0.7 0.00036 20.9 0.7 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein LGE1 Spem1 PF15670.3 MSTRG.21592.1_1 - 0.52 9.7 7.5 0.14 11.5 4.3 1.6 2 0 0 2 2 2 0 Spermatid maturation protein 1 TraF PF13728.4 MSTRG.21592.1_1 - 1.8 8.2 5.7 3.2 7.4 5.7 1.4 1 1 0 1 1 1 0 F plasmid transfer operon protein KH_1 PF00013.27 MSTRG.24997.1_3 - 8.8e-66 217.5 10.4 4.4e-17 61.5 0.1 4.3 4 0 0 4 4 4 4 KH domain KH_2 PF07650.15 MSTRG.24997.1_3 - 1e-17 63.5 8.4 0.00023 20.8 0.3 4.3 4 0 0 4 4 4 4 KH domain DUF1897 PF09005.8 MSTRG.24997.1_3 - 7.8e-13 47.5 38.3 7.4e-07 28.4 4.0 4.5 3 1 1 4 4 4 4 Domain of unknown function (DUF1897) KH_4 PF13083.4 MSTRG.24997.1_3 - 7.5e-09 35.2 6.4 0.011 15.4 0.0 4.3 4 0 0 4 4 4 3 KH domain SARG PF15385.4 MSTRG.2615.1_2 - 2.9e-27 96.0 26.7 1.4e-18 67.4 0.7 3.2 1 1 1 3 3 3 3 Specifically androgen-regulated gene protein NHL PF01436.19 MSTRG.15985.1_3 - 8.8e-05 22.2 0.0 0.0031 17.4 0.0 2.5 2 0 0 2 2 2 1 NHL repeat S_locus_glycop PF00954.18 MSTRG.15985.1_3 - 0.048 14.1 0.1 0.062 13.7 0.1 1.2 1 0 0 1 1 1 0 S-locus glycoprotein domain MOSC PF03473.15 MSTRG.8834.1_2 - 1.2e-30 106.1 0.0 1.7e-30 105.6 0.0 1.2 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.14 MSTRG.8834.1_2 - 1e-16 60.7 0.0 1.7e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain BRCT PF00533.24 MSTRG.15457.1_1 - 0.069 13.4 0.0 0.094 13.0 0.0 1.2 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain OB_NTP_bind PF07717.14 MSTRG.6563.1_3 - 1.7e-22 79.6 0.0 3.8e-22 78.4 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.21 MSTRG.6563.1_3 - 1.9e-21 76.2 0.0 3.7e-21 75.3 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.29 MSTRG.6563.1_3 - 3.4e-15 56.2 0.2 1e-14 54.7 0.1 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.27 MSTRG.6563.1_3 - 1.4e-05 24.8 0.1 4.2e-05 23.2 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.4 MSTRG.6563.1_3 - 0.00016 21.8 0.0 0.00042 20.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.25 MSTRG.6563.1_3 - 0.0018 18.7 0.2 0.087 13.2 0.2 2.5 1 1 0 1 1 1 1 ABC transporter AAA_19 PF13245.4 MSTRG.6563.1_3 - 0.0057 16.9 0.0 0.014 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.4 MSTRG.6563.1_3 - 0.0077 15.8 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain TPR_14 PF13428.4 MSTRG.9771.1_3 - 0.037 14.7 6.8 0.072 13.8 2.3 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.9771.1_3 - 0.15 12.5 4.1 21 5.6 0.0 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat zf-C4 PF00105.16 MSTRG.1503.2_2 - 4.8e-33 113.3 15.7 1.6e-32 111.6 15.7 2.0 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 MSTRG.1503.2_2 - 1.6e-23 83.3 0.1 3.7e-23 82.1 0.1 1.6 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor SelP_N PF04592.12 MSTRG.1503.2_3 - 2.6 7.3 12.5 4.4 6.5 12.5 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Adaptin_N PF01602.18 MSTRG.16320.6_2 - 1.2e-146 489.2 7.6 1.5e-146 488.9 7.6 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.18 MSTRG.16320.6_2 - 9.8e-10 38.6 0.1 2e-09 37.6 0.1 1.5 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.5 MSTRG.16320.6_2 - 5.1e-09 36.2 1.2 7e-07 29.2 0.0 2.6 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 RIX1 PF08167.10 MSTRG.16320.6_2 - 7.5e-05 22.4 3.3 0.0012 18.5 0.4 3.3 2 1 0 3 3 3 1 rRNA processing/ribosome biogenesis HEAT_2 PF13646.4 MSTRG.16320.6_2 - 9.9e-05 22.5 1.8 0.013 15.8 0.1 4.1 3 1 0 3 3 3 1 HEAT repeats Dymeclin PF09742.7 MSTRG.16320.6_2 - 0.022 13.2 1.0 0.037 12.4 1.0 1.3 1 0 0 1 1 1 0 Dyggve-Melchior-Clausen syndrome protein IFRD PF05004.11 MSTRG.16320.6_2 - 0.15 11.1 4.2 0.58 9.1 1.4 2.3 2 0 0 2 2 2 0 Interferon-related developmental regulator (IFRD) TIP120 PF08623.8 MSTRG.16320.6_2 - 0.56 9.9 2.2 20 4.8 0.2 2.4 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) ABC1 PF03109.14 MSTRG.391.1_3 - 0.16 12.0 0.1 0.22 11.5 0.1 1.2 1 0 0 1 1 1 0 ABC1 family DUF4106 PF13388.4 MSTRG.4811.3_1 - 0.28 10.2 1.3 0.4 9.7 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) GRAM PF02893.18 MSTRG.4811.3_3 - 1.3e-09 37.7 0.0 2e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 GRAM domain Vps36_ESCRT-II PF11605.6 MSTRG.4811.3_3 - 0.0017 18.4 0.0 0.0027 17.7 0.0 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 TIMP PF00965.15 MSTRG.10965.4_1 - 4.5e-13 49.3 2.2 5.8e-13 48.9 2.2 1.1 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase TIMP PF00965.15 MSTRG.10965.4_2 - 1.2e-24 87.0 0.5 1.6e-24 86.6 0.5 1.2 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.19 MSTRG.10965.4_2 - 0.002 17.8 0.0 0.0037 16.9 0.0 1.5 1 0 0 1 1 1 1 UNC-6/NTR/C345C module DUF1173 PF06666.9 MSTRG.10965.4_2 - 0.12 11.1 0.0 0.17 10.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1173) DUF4828 PF16110.3 MSTRG.7620.1_2 - 0.11 12.8 0.1 0.14 12.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4828) DUF1242 PF06842.10 MSTRG.11871.1_3 - 0.014 15.1 0.1 0.014 15.1 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1242) Acetyltransf_1 PF00583.23 MSTRG.521.1_2 - 2.3e-07 30.9 0.0 3.1e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.5 MSTRG.521.1_2 - 2.1e-05 24.4 0.0 2.5e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Pkinase PF00069.23 MSTRG.26284.1_3 - 9.3e-75 251.2 0.1 1.9e-74 250.3 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.26284.1_3 - 4e-34 117.9 0.0 5.7e-34 117.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.27 MSTRG.26284.1_3 - 7.8e-15 55.1 0.1 2.5e-14 53.5 0.1 1.9 1 0 0 1 1 1 1 PH domain Pkinase_C PF00433.22 MSTRG.26284.1_3 - 9.2e-09 35.7 3.6 9.2e-09 35.7 3.6 1.9 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.4 MSTRG.26284.1_3 - 5.5e-06 25.8 0.0 1e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.4 MSTRG.26284.1_3 - 0.039 13.4 0.3 5.2 6.5 0.1 2.2 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DUF4400 PF14348.4 MSTRG.9079.1_1 - 0.082 12.3 0.0 0.098 12.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) T-box PF00907.20 MSTRG.21229.2_1 - 3.1e-49 167.6 0.2 6.6e-49 166.5 0.1 1.5 2 0 0 2 2 2 1 T-box PADR1 PF08063.10 MSTRG.21229.2_3 - 3.5 7.3 5.9 0.97 9.1 0.3 2.2 2 0 0 2 2 2 0 PADR1 (NUC008) domain 4F5 PF04419.12 MSTRG.6119.1_1 - 4.6e-11 43.3 13.7 4.6e-11 43.3 13.7 2.1 2 0 0 2 2 2 1 4F5 protein family zf-met PF12874.5 MSTRG.6119.1_1 - 0.00074 19.7 0.3 0.0019 18.4 0.3 1.8 1 0 0 1 1 1 1 Zinc-finger of C2H2 type Transposase_22 PF02994.12 MSTRG.4878.1_1 - 5.1e-05 22.2 7.2 5.1e-05 22.2 7.2 2.3 2 1 0 2 2 2 1 L1 transposable element RimM PF01782.16 MSTRG.4878.1_1 - 0.027 14.6 0.1 0.12 12.5 0.1 2.2 2 0 0 2 2 2 0 RimM N-terminal domain Laminin_I PF06008.12 MSTRG.4878.1_1 - 0.21 11.1 4.2 0.3 10.6 2.5 1.8 2 0 0 2 2 2 0 Laminin Domain I DUF4407 PF14362.4 MSTRG.4878.1_1 - 0.49 9.6 2.8 0.72 9.0 2.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) eIF-3_zeta PF05091.10 MSTRG.19469.1_2 - 3.2e-214 712.6 6.2 3.7e-214 712.4 6.2 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NARG2_C PF10505.7 MSTRG.19469.1_2 - 0.00018 21.0 0.0 0.0021 17.5 0.0 2.2 1 1 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus CENP-B_dimeris PF09026.8 MSTRG.19469.1_2 - 0.53 10.6 7.8 1.4 9.2 7.8 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain SprA-related PF12118.6 MSTRG.19469.1_2 - 3.7 6.5 6.8 7 5.5 6.8 1.3 1 0 0 1 1 1 0 SprA-related family LMF1 PF06762.12 MSTRG.2431.1_1 - 7.9e-14 51.4 3.8 1.4e-13 50.5 3.8 1.4 1 0 0 1 1 1 1 Lipase maturation factor PP_M1 PF03012.12 MSTRG.2431.1_1 - 0.43 9.9 3.5 0.57 9.5 3.5 1.1 1 0 0 1 1 1 0 Phosphoprotein FAM176 PF14851.4 MSTRG.2431.1_1 - 1.6 8.2 5.8 3.7 7.1 5.8 1.6 1 1 0 1 1 1 0 FAM176 family IGFBP PF00219.16 MSTRG.2431.1_2 - 2.1 8.9 11.9 4.2 8.0 11.9 1.5 1 0 0 1 1 1 0 Insulin-like growth factor binding protein Recep_L_domain PF01030.22 MSTRG.22889.2_3 - 3.3e-57 191.3 2.4 4.9e-30 103.8 0.1 2.4 2 0 0 2 2 2 2 Receptor L domain GF_recep_IV PF14843.4 MSTRG.22889.2_3 - 6.3e-54 181.2 84.7 4.5e-47 159.0 31.0 4.3 2 1 1 3 3 3 3 Growth factor receptor domain IV Furin-like PF00757.18 MSTRG.22889.2_3 - 4.7e-37 127.0 90.6 2.8e-29 101.8 41.6 4.3 2 1 2 4 4 4 4 Furin-like cysteine rich region DUF4298 PF14131.4 MSTRG.22889.2_3 - 0.14 12.1 0.2 3.8 7.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) Glycolytic PF00274.17 MSTRG.10279.1_2 - 1.4e-180 599.5 0.0 1.6e-180 599.2 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I CAP PF00188.24 MSTRG.18092.1_3 - 2e-19 70.5 0.9 3.1e-19 69.9 0.9 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family RRM_5 PF13893.4 MSTRG.7044.1_2 - 7.3e-29 99.8 1.6 1.3e-24 86.1 0.1 2.6 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.20 MSTRG.7044.1_2 - 1e-08 34.7 0.0 0.0025 17.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 MSTRG.7044.1_2 - 3e-05 23.6 0.2 0.0048 16.6 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif Limkain-b1 PF11608.6 MSTRG.7044.1_2 - 0.0074 16.2 0.0 6.1 6.9 0.0 2.4 2 0 0 2 2 2 2 Limkain b1 RRM_1 PF00076.20 MSTRG.7044.1_3 - 8.3e-12 44.6 0.7 4.4e-08 32.7 0.1 2.7 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 MSTRG.7044.1_3 - 2.3e-10 40.0 2.0 9.9e-05 21.8 0.3 2.8 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 MSTRG.7044.1_3 - 0.0099 15.6 0.0 0.95 9.2 0.0 2.4 2 0 0 2 2 2 2 Occluded RNA-recognition motif zf-BED PF02892.13 MSTRG.23991.1_1 - 0.094 12.7 0.1 0.094 12.7 0.1 3.0 4 0 0 4 4 4 0 BED zinc finger PI-PLC-X PF00388.17 MSTRG.23991.1_2 - 9.6e-06 25.1 0.1 2.2e-05 23.9 0.0 1.6 1 1 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain COX15-CtaA PF02628.13 MSTRG.4158.1_1 - 1.7e-110 369.0 4.4 2.1e-110 368.7 4.4 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein Peptidase_S3 PF00944.17 MSTRG.4158.1_1 - 0.11 12.1 0.2 0.17 11.5 0.2 1.2 1 0 0 1 1 1 0 Alphavirus core protein Nebulin PF00880.16 MSTRG.1479.17_2 - 4.4e-199 643.0 173.6 7.7e-11 41.6 2.0 45.9 47 0 0 47 47 47 41 Nebulin repeat SH3_9 PF14604.4 MSTRG.1479.17_2 - 1.1e-12 47.5 0.0 2.2e-12 46.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.1479.17_2 - 1.3e-12 46.9 0.5 4.4e-12 45.3 0.0 2.2 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 MSTRG.1479.17_2 - 8.4e-06 25.3 0.0 2.4e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Ig_3 PF13927.4 MSTRG.22310.1_2 - 2.4e-11 43.9 0.1 1.6e-05 25.3 0.1 2.8 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 MSTRG.22310.1_2 - 2.7e-09 36.9 0.5 4.2e-05 23.5 0.3 3.0 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.22310.1_2 - 3.9e-09 36.6 0.3 0.00089 19.4 0.2 3.4 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 MSTRG.22310.1_2 - 2.9e-07 30.5 0.0 1.5e-05 24.9 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.14 MSTRG.22310.1_2 - 8.3e-07 28.9 0.1 0.0007 19.5 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin I-set domain Adeno_E3_CR2 PF02439.13 MSTRG.22310.1_2 - 0.00037 20.1 0.3 0.00037 20.1 0.3 1.8 2 0 0 2 2 2 1 Adenovirus E3 region protein CR2 IncA PF04156.12 MSTRG.22310.1_2 - 0.15 11.7 0.0 0.38 10.4 0.0 1.6 1 1 0 1 1 1 0 IncA protein LSR PF05624.12 MSTRG.22310.1_3 - 1.9e-20 72.4 38.7 9.4e-20 70.2 38.7 2.3 1 0 0 1 1 1 1 Lipolysis stimulated receptor (LSR) V-set PF07686.15 MSTRG.22310.1_3 - 1.7e-07 31.2 0.5 0.00066 19.7 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.4 MSTRG.22310.1_3 - 0.0048 17.3 1.0 0.037 14.5 1.0 2.3 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 MSTRG.22310.1_3 - 0.031 14.2 0.6 0.082 12.9 0.0 1.9 2 0 0 2 2 2 0 Immunoglobulin I-set domain S-methyl_trans PF02574.14 MSTRG.9251.1_2 - 6.6e-49 167.0 0.0 8e-49 166.7 0.0 1.1 1 0 0 1 1 1 1 Homocysteine S-methyltransferase DUF4821 PF16092.3 MSTRG.9251.1_2 - 0.067 12.7 0.0 0.1 12.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4821) Elf-1_N PF12310.6 MSTRG.10247.2_1 - 4.9e-34 117.1 2.9 8.8e-34 116.3 2.9 1.4 1 0 0 1 1 1 1 Transcription factor protein N terminal Ets PF00178.20 MSTRG.10247.2_1 - 6.8e-34 116.1 1.4 1.3e-33 115.2 1.4 1.5 1 0 0 1 1 1 1 Ets-domain Ig_3 PF13927.4 MSTRG.8500.1_1 - 0.0045 17.4 1.3 0.0052 17.2 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.15 MSTRG.8500.1_1 - 0.03 14.3 0.4 0.35 10.9 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin V-set domain SCIMP PF15050.4 MSTRG.8500.1_1 - 0.13 12.6 0.4 0.29 11.4 0.4 1.5 1 0 0 1 1 1 0 SCIMP protein DUF912 PF06024.10 MSTRG.8500.1_1 - 1.5 9.0 3.9 1.6 8.9 0.0 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Pkinase PF00069.23 MSTRG.27063.2_2 - 1.1e-73 247.7 0.0 1.5e-73 247.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.27063.2_2 - 6.7e-47 159.8 0.0 1.1e-46 159.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 MSTRG.27063.2_2 - 5.9e-24 84.1 0.0 1.3e-23 83.0 0.0 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 MSTRG.27063.2_2 - 1.7e-07 30.7 0.1 0.00046 19.5 0.0 2.3 1 1 1 2 2 2 2 Kinase-like APH PF01636.21 MSTRG.27063.2_2 - 0.009 15.8 0.0 0.16 11.8 0.1 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.12 MSTRG.27063.2_2 - 0.037 13.2 0.0 0.069 12.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RabGAP-TBC PF00566.16 MSTRG.1793.1_3 - 1.6e-11 44.1 0.6 1.7e-09 37.5 0.4 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain GKAP PF03359.11 MSTRG.13782.2_1 - 6.9e-39 134.2 18.6 9.8e-29 100.8 7.1 2.8 3 0 0 3 3 3 2 Guanylate-kinase-associated protein (GKAP) protein GKAP PF03359.11 MSTRG.13782.2_3 - 1.6e-88 297.5 0.5 2.5e-88 296.8 0.5 1.1 1 0 0 1 1 1 1 Guanylate-kinase-associated protein (GKAP) protein Lectin_C PF00059.19 MSTRG.2051.1_1 - 8.5e-14 52.1 0.0 2e-13 50.9 0.0 1.6 1 0 0 1 1 1 1 Lectin C-type domain DUF1515 PF07439.9 MSTRG.2051.1_1 - 0.16 11.8 0.0 0.28 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) DUF2312 PF10073.7 MSTRG.2051.1_1 - 0.25 10.9 1.9 0.33 10.5 0.7 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) Glyco_hydro_63 PF03200.14 MSTRG.27757.1_2 - 2.1e-218 725.9 0.7 2.6e-218 725.6 0.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.3 MSTRG.27757.1_2 - 7.6e-49 166.7 0.5 1.4e-48 165.8 0.5 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 N-terminal domain GDE_C PF06202.12 MSTRG.27757.1_2 - 5.8e-08 31.9 0.1 1e-07 31.1 0.1 1.4 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase Trehalase PF01204.16 MSTRG.27757.1_2 - 0.00084 18.1 0.2 0.0016 17.3 0.2 1.3 1 0 0 1 1 1 1 Trehalase RVT_1 PF00078.25 MSTRG.21450.1_3 - 0.0033 16.8 0.0 0.043 13.2 0.0 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PMP22_Claudin PF00822.18 MSTRG.22456.1_1 - 6.1e-24 84.6 10.1 9.7e-24 84.0 10.1 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 MSTRG.22456.1_1 - 1.9e-06 27.7 14.3 1e-05 25.3 14.3 1.9 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF21 PF01595.18 MSTRG.22456.1_1 - 0.03 13.9 0.7 0.051 13.2 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF21 DUF1455 PF07306.9 MSTRG.22456.1_3 - 0.24 11.2 4.9 5.7 6.8 0.5 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1455) DAG_kinase_N PF14513.4 MSTRG.5603.1_3 - 0.16 12.0 0.0 0.19 11.8 0.0 1.2 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus ACBP PF00887.17 MSTRG.20773.1_1 - 1.2e-32 111.9 0.2 1.5e-32 111.5 0.2 1.1 1 0 0 1 1 1 1 Acyl CoA binding protein 7tm_2 PF00002.22 MSTRG.3375.1_1 - 2.3e-15 56.4 4.3 3.6e-15 55.8 4.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) UPF0233 PF06781.10 MSTRG.3375.1_1 - 0.049 13.6 0.7 0.091 12.7 0.7 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0233) tRNA-synt_2b PF00587.23 MSTRG.10708.1_2 - 6.6e-39 133.6 0.0 9.4e-39 133.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.18 MSTRG.10708.1_2 - 5e-08 32.9 0.0 1.2e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain MBT PF02820.16 MSTRG.14272.2_3 - 2.3e-46 155.9 0.0 2.2e-23 82.2 0.0 2.4 2 0 0 2 2 2 2 mbt repeat SLED PF12140.6 MSTRG.14272.2_3 - 4.7e-33 113.9 0.5 7.6e-33 113.2 0.5 1.3 1 0 0 1 1 1 1 SLED domain RBR PF17208.1 MSTRG.14272.2_3 - 6.9e-22 77.8 32.6 1.9e-10 41.2 11.2 3.0 2 0 0 2 2 2 2 RNA binding Region SAM_1 PF00536.28 MSTRG.14272.2_3 - 5.4e-15 55.5 0.1 1e-14 54.6 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 MSTRG.14272.2_3 - 1.3e-05 25.1 0.0 2.7e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 MSTRG.14272.2_3 - 0.0056 16.5 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain 2OG-FeII_Oxy_3 PF13640.4 MSTRG.11088.1_3 - 5.1e-06 27.2 0.1 9.5e-06 26.3 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.18 MSTRG.11088.1_3 - 7.3e-05 23.1 0.1 0.00015 22.0 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-C3HC4 PF00097.23 MSTRG.7047.2_1 - 1.1e-10 41.0 4.3 1.1e-10 41.0 4.3 3.1 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 MSTRG.7047.2_1 - 6.9e-10 38.8 7.5 6.9e-10 38.8 7.5 2.6 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 MSTRG.7047.2_1 - 7.8e-10 38.3 7.3 7.8e-10 38.3 7.3 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.7047.2_1 - 3.1e-09 36.6 7.8 4.9e-09 35.9 2.7 3.0 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 MSTRG.7047.2_1 - 2.8e-08 33.4 3.2 2.8e-08 33.4 3.2 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.7047.2_1 - 6.1e-08 32.7 8.3 6.1e-08 32.7 8.3 3.3 3 0 0 3 3 3 1 Ring finger domain PRY PF13765.4 MSTRG.7047.2_1 - 9.3e-07 28.2 0.0 2.5e-06 26.8 0.0 1.8 1 0 0 1 1 1 1 SPRY-associated domain zf-B_box PF00643.22 MSTRG.7047.2_1 - 1e-06 28.6 4.6 1e-06 28.6 4.6 2.8 3 0 0 3 3 2 1 B-box zinc finger zf-RING_5 PF14634.4 MSTRG.7047.2_1 - 4.3e-05 23.3 4.3 4.3e-05 23.3 4.3 3.3 3 0 0 3 3 3 1 zinc-RING finger domain zf-Nse PF11789.6 MSTRG.7047.2_1 - 5.1e-05 22.9 0.6 0.00013 21.6 0.6 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.4 MSTRG.7047.2_1 - 0.00018 21.1 1.7 0.00053 19.7 1.7 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.4 MSTRG.7047.2_1 - 0.0004 20.0 4.7 0.0004 20.0 4.7 2.9 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 U-box PF04564.13 MSTRG.7047.2_1 - 0.00063 19.7 0.0 0.0018 18.3 0.0 1.8 1 0 0 1 1 1 1 U-box domain zf-ANAPC11 PF12861.5 MSTRG.7047.2_1 - 0.0088 15.9 1.7 0.027 14.4 1.7 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger BAR_3_WASP_bdg PF10456.7 MSTRG.7047.2_1 - 0.011 15.1 0.3 0.019 14.3 0.3 1.3 1 0 0 1 1 1 0 WASP-binding domain of Sorting nexin protein BDV_P24 PF06595.9 MSTRG.7047.2_1 - 0.064 13.0 0.4 0.11 12.2 0.4 1.3 1 0 0 1 1 1 0 Borna disease virus P24 protein zf-rbx1 PF12678.5 MSTRG.7047.2_1 - 2 8.6 15.4 0.43 10.8 9.9 2.7 2 1 1 3 3 3 0 RING-H2 zinc finger domain DZR PF12773.5 MSTRG.7047.2_1 - 2.5 8.1 9.9 6.1 6.8 0.7 2.9 2 0 0 2 2 2 0 Double zinc ribbon HR1 PF02185.14 MSTRG.12154.2_2 - 3e-44 148.9 29.9 1.1e-16 60.5 7.6 3.5 3 0 0 3 3 3 3 Hr1 repeat Uds1 PF15456.4 MSTRG.12154.2_2 - 0.0078 16.2 26.2 0.033 14.2 5.4 3.8 3 1 1 4 4 4 3 Up-regulated During Septation YgbB PF02542.14 MSTRG.12154.2_2 - 0.09 12.9 2.0 1.1 9.4 0.3 2.5 2 1 0 2 2 2 0 YgbB family PTPlike_phytase PF14566.4 MSTRG.12154.2_2 - 0.47 10.5 4.5 0.47 10.4 2.8 1.8 1 1 0 2 2 2 0 Inositol hexakisphosphate WD40 PF00400.30 MSTRG.4715.1_2 - 6.9e-06 26.6 0.9 0.0036 18.0 0.3 2.7 2 0 0 2 2 2 2 WD domain, G-beta repeat Tropomyosin PF00261.18 MSTRG.3643.1_2 - 1.3e-67 227.5 56.8 1.6e-67 227.2 56.8 1.1 1 0 0 1 1 1 1 Tropomyosin Tropomyosin_1 PF12718.5 MSTRG.3643.1_2 - 1.1e-15 57.9 52.9 4.6e-14 52.6 23.6 2.9 1 1 1 2 2 2 2 Tropomyosin like TMF_DNA_bd PF12329.6 MSTRG.3643.1_2 - 0.002 17.9 6.3 0.002 17.9 6.3 5.2 3 2 2 5 5 5 1 TATA element modulatory factor 1 DNA binding Laminin_II PF06009.10 MSTRG.3643.1_2 - 0.031 14.2 27.3 0.66 9.9 7.7 3.3 1 1 2 3 3 3 0 Laminin Domain II DUF3887 PF13026.4 MSTRG.3643.1_2 - 0.035 14.8 0.2 0.11 13.2 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3887) XhlA PF10779.7 MSTRG.3643.1_2 - 0.32 11.1 24.4 0.76 9.9 0.3 4.8 3 1 2 5 5 5 0 Haemolysin XhlA CCDC144C PF14915.4 MSTRG.3643.1_2 - 0.76 8.7 42.4 0.98 8.3 42.4 1.1 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region DUF1664 PF07889.10 MSTRG.3643.1_2 - 0.85 9.5 21.3 0.88 9.4 2.5 2.9 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) CALCOCO1 PF07888.9 MSTRG.3643.1_2 - 1.3 7.3 41.0 1.9 6.8 41.0 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DASH_Duo1 PF08651.8 MSTRG.3643.1_2 - 1.7 8.3 7.8 1 9.0 0.5 3.0 3 0 0 3 3 3 0 DASH complex subunit Duo1 CENP-F_leu_zip PF10473.7 MSTRG.3643.1_2 - 1.9 8.4 52.7 11 5.9 29.8 2.5 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.10 MSTRG.3643.1_2 - 4.7 7.2 56.2 0.74 9.7 23.4 3.5 1 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein ERM PF00769.17 MSTRG.3643.1_2 - 7 6.3 62.7 0.3 10.7 31.9 2.5 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Lebercilin PF15619.4 MSTRG.3643.1_2 - 8.8 5.8 49.7 3.1 7.3 14.2 3.0 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease EzrA PF06160.10 MSTRG.3643.1_2 - 9 4.2 36.2 4 5.4 7.8 2.4 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Fib_alpha PF08702.8 MSTRG.3643.1_2 - 9.5 6.3 23.5 5 7.2 3.0 2.9 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family DUF745 PF05335.11 MSTRG.3643.1_2 - 10 5.7 42.4 1.2 8.7 11.1 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF745) Thymidylate_kin PF02223.15 MSTRG.17659.1_3 - 1e-07 31.7 0.0 8.5e-07 28.7 0.0 2.3 1 1 0 1 1 1 1 Thymidylate kinase AAA_33 PF13671.4 MSTRG.17659.1_3 - 0.00056 19.9 0.0 0.0011 19.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 MSTRG.17659.1_3 - 0.044 14.0 0.0 0.11 12.7 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.4 MSTRG.17659.1_3 - 0.052 13.9 0.0 0.1 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain dNK PF01712.17 MSTRG.17659.1_3 - 0.11 12.2 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Deoxynucleoside kinase Cyclin_C_2 PF16899.3 MSTRG.12261.1_1 - 7.5e-24 84.0 0.1 8e-22 77.5 0.0 2.5 2 0 0 2 2 2 2 Cyclin C-terminal domain Cyclin_N PF00134.21 MSTRG.12261.1_1 - 5.2e-09 35.8 0.2 8.7e-09 35.1 0.2 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain TPR_12 PF13424.4 MSTRG.4673.2_1 - 2.4e-08 34.0 1.0 3.4e-08 33.5 0.2 1.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.4673.2_1 - 0.12 12.1 0.0 0.34 10.7 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF4658 PF15555.4 MSTRG.4673.2_2 - 4.8e-08 32.9 2.9 1.6e-07 31.3 2.9 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4658) Consortin_C PF15281.4 MSTRG.4673.2_2 - 1.7e-07 31.1 0.0 3.5e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Consortin C-terminus EGF PF00008.25 MSTRG.10915.1_1 - 4e-95 311.4 235.3 7.8e-09 35.5 6.1 17.0 16 0 0 16 16 16 16 EGF-like domain hEGF PF12661.5 MSTRG.10915.1_1 - 2.8e-50 167.2 227.8 2.6e-06 27.7 8.9 18.8 19 0 0 19 19 17 15 Human growth factor-like EGF Ank_2 PF12796.5 MSTRG.10915.1_1 - 3.5e-29 101.1 22.5 2.8e-11 43.7 1.8 4.2 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank PF00023.28 MSTRG.10915.1_1 - 1.2e-26 91.8 6.0 4.8e-06 26.6 0.0 6.9 6 0 0 6 6 6 5 Ankyrin repeat Notch PF00066.15 MSTRG.10915.1_1 - 3.9e-25 87.9 51.4 4.7e-11 42.8 9.6 10.7 10 2 0 10 10 3 3 LNR domain DUF3454 PF11936.6 MSTRG.10915.1_1 - 6.8e-25 87.1 24.3 6.8e-25 87.1 24.3 2.9 3 0 0 3 3 2 1 Domain of unknown function (DUF3454) NOD PF06816.11 MSTRG.10915.1_1 - 5.5e-21 73.8 0.0 9.2e-21 73.1 0.0 1.4 1 0 0 1 1 1 1 NOTCH protein Ank_5 PF13857.4 MSTRG.10915.1_1 - 9.3e-21 73.5 12.7 3.2e-08 33.6 0.6 5.6 3 2 2 5 5 5 4 Ankyrin repeats (many copies) NODP PF07684.10 MSTRG.10915.1_1 - 2.5e-19 69.0 0.0 2.5e-19 69.0 0.0 2.4 2 0 0 2 2 1 1 NOTCH protein Ank_3 PF13606.4 MSTRG.10915.1_1 - 1.1e-18 65.2 3.1 0.00056 20.0 0.0 6.7 6 0 0 6 6 6 4 Ankyrin repeat EGF_CA PF07645.13 MSTRG.10915.1_1 - 3.5e-16 59.0 255.3 7.9e-07 29.1 8.9 17.8 11 4 6 17 17 15 10 Calcium-binding EGF domain Ank_4 PF13637.4 MSTRG.10915.1_1 - 2.6e-15 56.4 2.2 1.8e-05 25.0 0.2 4.9 3 2 2 5 5 5 4 Ankyrin repeats (many copies) EGF_2 PF07974.11 MSTRG.10915.1_1 - 2.8e-13 49.8 295.1 0.0029 17.8 10.4 18.3 18 0 0 18 18 16 14 EGF-like domain EGF_3 PF12947.5 MSTRG.10915.1_1 - 0.0028 17.7 3.9 0.0028 17.7 3.9 17.9 14 4 3 17 17 14 8 EGF domain Gal-bind_lectin PF00337.20 MSTRG.22292.1_2 - 3.7e-18 65.2 0.0 5.8e-18 64.6 0.0 1.2 1 0 0 1 1 1 1 Galactoside-binding lectin Lectin_C PF00059.19 MSTRG.22292.1_2 - 1.3e-15 57.9 1.7 3.1e-15 56.7 1.7 1.7 1 0 0 1 1 1 1 Lectin C-type domain VWA PF00092.26 MSTRG.1336.1_2 - 1.7e-77 259.5 0.0 4.4e-39 134.4 0.0 2.1 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.4 MSTRG.1336.1_2 - 1.7e-26 92.8 0.0 6.8e-13 49.1 0.0 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain LCCL PF03815.17 MSTRG.1336.1_2 - 1e-19 70.3 0.0 1.7e-19 69.6 0.0 1.4 1 0 0 1 1 1 1 LCCL domain VWA_CoxE PF05762.12 MSTRG.1336.1_2 - 2.1e-06 27.2 0.1 0.014 14.7 0.0 2.4 2 0 0 2 2 2 2 VWA domain containing CoxE-like protein VWA_3 PF13768.4 MSTRG.1336.1_2 - 0.00024 20.9 0.0 0.22 11.2 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain Rxt3 PF08642.8 MSTRG.1336.1_2 - 0.014 16.0 0.1 0.099 13.3 0.1 2.4 1 1 0 1 1 1 0 Histone deacetylation protein Rxt3 FGF PF00167.16 MSTRG.10362.1_2 - 6.3e-40 136.0 0.1 9.2e-40 135.5 0.1 1.2 1 0 0 1 1 1 1 Fibroblast growth factor Lactamase_B_2 PF12706.5 MSTRG.29740.1_3 - 0.043 13.2 0.0 0.054 12.9 0.0 1.1 1 0 0 1 1 1 0 Beta-lactamase superfamily domain TPR_12 PF13424.4 MSTRG.7139.1_3 - 3.3e-92 302.7 44.5 2e-19 69.5 0.2 6.7 2 2 5 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.7139.1_3 - 6.1e-68 222.9 21.2 1.3e-11 43.8 0.4 9.1 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.7139.1_3 - 4.3e-35 117.0 20.1 1.7e-05 24.4 0.1 9.2 9 0 0 9 9 8 7 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.7139.1_3 - 8.4e-35 117.1 25.8 8.4e-06 25.3 0.2 8.7 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.7139.1_3 - 7.6e-23 78.7 28.1 0.00085 19.2 0.7 9.6 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.7139.1_3 - 6.5e-21 72.6 31.9 0.00033 20.4 0.1 8.5 8 0 0 8 8 7 7 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.7139.1_3 - 5.5e-12 46.0 15.1 0.0016 18.9 0.3 7.2 4 1 3 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.7139.1_3 - 1.8e-11 44.3 13.8 0.02 15.3 1.2 5.7 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.7139.1_3 - 6.1e-09 35.8 13.3 0.63 10.9 0.7 7.6 3 2 4 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.7139.1_3 - 1.3e-08 34.5 12.9 4.2 7.8 0.0 9.2 9 1 0 9 9 8 1 Tetratricopeptide repeat NACHT PF05729.10 MSTRG.7139.1_3 - 2.8e-06 27.2 0.4 1e-05 25.4 0.0 2.0 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.4 MSTRG.7139.1_3 - 2e-05 24.9 0.4 0.00099 19.4 0.0 3.4 2 1 0 2 2 2 1 AAA ATPase domain MIT PF04212.16 MSTRG.7139.1_3 - 0.00026 20.9 19.8 1.7 8.6 0.0 6.6 4 3 2 6 6 5 2 MIT (microtubule interacting and transport) domain TPR_11 PF13414.4 MSTRG.7139.1_3 - 0.00037 20.0 20.0 0.13 11.9 0.0 7.3 8 0 0 8 8 7 1 TPR repeat KAP_NTPase PF07693.12 MSTRG.7139.1_3 - 0.00072 18.8 0.1 0.057 12.5 0.0 2.7 2 1 1 3 3 3 1 KAP family P-loop domain DUF2225 PF09986.7 MSTRG.7139.1_3 - 0.0014 18.3 6.0 0.048 13.3 0.0 3.2 2 2 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_9 PF13371.4 MSTRG.7139.1_3 - 0.003 17.5 7.2 0.53 10.3 0.2 4.4 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_4 PF07721.12 MSTRG.7139.1_3 - 0.0031 17.8 0.3 1.6e+02 3.2 0.0 5.7 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_3 PF07720.10 MSTRG.7139.1_3 - 0.0044 16.8 15.3 0.25 11.2 0.6 5.5 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.7139.1_3 - 0.0052 17.2 17.1 5.7 7.7 0.0 7.6 8 0 0 8 8 7 0 Tetratricopeptide repeat AAA_22 PF13401.4 MSTRG.7139.1_3 - 0.0073 16.4 0.0 0.057 13.6 0.0 2.6 2 0 0 2 2 1 1 AAA domain AAA_19 PF13245.4 MSTRG.7139.1_3 - 0.01 16.1 0.0 0.11 12.7 0.0 2.6 2 1 0 2 2 2 0 AAA domain AAA PF00004.27 MSTRG.7139.1_3 - 0.015 15.6 0.0 0.05 13.9 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.16 MSTRG.7139.1_3 - 0.019 14.7 0.0 0.042 13.6 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DUF627 PF04781.10 MSTRG.7139.1_3 - 0.028 14.3 5.1 3.3 7.6 0.0 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF627) DUF4404 PF14357.4 MSTRG.7139.1_3 - 0.06 13.9 0.9 11 6.7 0.1 4.5 4 1 1 5 5 3 0 Domain of unknown function (DUF4404) SHNi-TPR PF10516.7 MSTRG.7139.1_3 - 0.067 12.5 6.4 2.5 7.5 0.1 4.9 6 0 0 6 6 6 0 SHNi-TPR cobW PF02492.17 MSTRG.7139.1_3 - 0.09 12.2 0.0 7.1 6.1 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ANAPC3 PF12895.5 MSTRG.7139.1_3 - 0.15 12.2 14.6 1.9 8.6 1.6 4.9 3 2 2 5 5 4 0 Anaphase-promoting complex, cyclosome, subunit 3 RPN7 PF10602.7 MSTRG.7139.1_3 - 3.2 7.2 10.5 55 3.2 0.0 5.1 3 2 2 5 5 5 0 26S proteasome subunit RPN7 PhdYeFM_antitox PF02604.17 MSTRG.783.1_3 - 0.031 13.9 0.1 0.042 13.5 0.1 1.2 1 0 0 1 1 1 0 Antitoxin Phd_YefM, type II toxin-antitoxin system BsuBI_PstI_RE PF06616.9 MSTRG.783.1_3 - 0.071 11.8 0.1 0.073 11.8 0.1 1.1 1 0 0 1 1 1 0 BsuBI/PstI restriction endonuclease C-terminus zf-H2C2_2 PF13465.4 MSTRG.11103.1_1 - 6.7e-80 260.1 72.6 1.5e-09 37.7 1.0 12.0 12 0 0 12 12 12 11 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.11103.1_1 - 5.9e-49 161.7 88.9 9.9e-06 25.6 2.1 11.5 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.11103.1_1 - 5.3e-39 129.4 83.6 0.0014 19.2 1.3 11.6 11 0 0 11 11 11 11 C2H2-type zinc finger zf-met PF12874.5 MSTRG.11103.1_1 - 6.6e-26 89.8 78.8 6.7e-05 23.0 1.5 11.6 11 0 0 11 11 11 9 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.11103.1_1 - 1.9e-16 59.8 45.8 0.028 14.6 0.1 11.8 11 1 0 11 11 11 6 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 MSTRG.11103.1_1 - 4.7e-11 42.7 53.0 2.3e-05 24.5 2.6 7.4 3 1 6 10 10 9 9 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.4 MSTRG.11103.1_1 - 8.1e-11 41.5 72.8 0.0087 15.9 0.7 12.4 12 1 0 12 12 11 6 C2H2-type zinc finger zf-C2H2_2 PF12756.5 MSTRG.11103.1_1 - 2.4e-09 37.3 54.9 0.26 11.5 0.6 11.2 1 1 7 9 9 9 5 C2H2 type zinc-finger (2 copies) Ta0938 PF11494.6 MSTRG.11103.1_1 - 0.00075 19.6 17.8 4.5 7.5 0.1 6.5 2 2 6 8 8 8 2 Ta0938 zf-LYAR PF08790.9 MSTRG.11103.1_1 - 0.0077 16.0 56.0 3.9 7.3 1.2 11.0 12 0 0 12 12 12 4 LYAR-type C2HC zinc finger ADK_lid PF05191.12 MSTRG.11103.1_1 - 0.064 13.2 20.2 0.66 9.9 0.2 6.9 5 1 2 7 7 7 0 Adenylate kinase, active site lid Trm112p PF03966.14 MSTRG.11103.1_1 - 0.5 10.8 5.4 16 6.0 0.1 4.6 3 3 0 3 3 3 0 Trm112p-like protein zinc_ribbon_15 PF17032.3 MSTRG.11103.1_1 - 0.74 10.5 32.0 1.9 9.2 0.4 5.9 1 1 7 8 8 8 0 zinc-ribbon family Elf1 PF05129.11 MSTRG.11103.1_1 - 0.78 9.7 42.6 0.18 11.8 1.0 6.7 1 1 6 7 7 7 0 Transcription elongation factor Elf1 like zf-AN1 PF01428.14 MSTRG.11103.1_1 - 3.9 7.6 48.6 10 6.2 0.2 10.7 10 1 1 11 11 11 0 AN1-like Zinc finger Zn-ribbon_8 PF09723.8 MSTRG.11103.1_1 - 5.6 7.0 36.5 1 9.4 1.1 7.6 5 2 3 8 8 8 0 Zinc ribbon domain GAGA PF09237.9 MSTRG.11103.1_1 - 6.1 6.6 19.8 12 5.6 0.0 6.8 3 2 4 8 8 8 0 GAGA factor BolA PF01722.16 MSTRG.11103.1_1 - 6.4 7.0 16.7 44 4.3 4.4 5.8 3 2 1 4 4 4 0 BolA-like protein DUF2180 PF09947.7 MSTRG.11103.1_1 - 7.1 6.6 20.5 35 4.3 0.7 6.1 1 1 3 6 6 6 0 Uncharacterized protein conserved in archaea (DUF2180) LIM PF00412.20 MSTRG.11103.1_1 - 8.6 6.5 47.7 7.1 6.8 2.6 8.2 1 1 6 8 8 8 0 LIM domain PAP2 PF01569.19 MSTRG.16422.1_2 - 2.9e-12 46.4 7.2 2.9e-12 46.4 7.2 2.7 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.4 MSTRG.16422.1_2 - 0.0011 18.5 5.3 0.0011 18.5 5.3 2.2 2 0 0 2 2 2 1 PAP2 superfamily HMG_box PF00505.17 MSTRG.2488.4_2 - 8.8e-51 170.1 58.7 3.1e-16 59.4 3.8 7.3 7 0 0 7 7 7 6 HMG (high mobility group) box HMG_box_5 PF14887.4 MSTRG.2488.4_2 - 1.5e-49 165.8 29.0 1.1e-47 159.7 5.0 4.1 4 0 0 4 4 4 2 HMG (high mobility group) box 5 HMG_box_2 PF09011.8 MSTRG.2488.4_2 - 1.4e-23 83.1 50.0 9.8e-07 29.2 2.9 6.7 6 1 0 6 6 6 6 HMG-box domain YABBY PF04690.11 MSTRG.2488.4_2 - 0.94 9.9 6.1 0.51 10.7 2.7 2.4 2 0 0 2 2 2 0 YABBY protein DUF1074 PF06382.9 MSTRG.2488.4_2 - 1.7 8.7 24.4 2.1 8.4 0.4 5.4 4 2 2 6 6 6 0 Protein of unknown function (DUF1074) RRM_1 PF00076.20 MSTRG.2562.1_1 - 6.5e-17 61.0 0.0 1e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.2562.1_1 - 0.0011 18.9 0.0 0.0019 18.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif Limkain-b1 PF11608.6 MSTRG.2562.1_1 - 0.002 18.0 0.0 0.0042 17.0 0.0 1.5 1 0 0 1 1 1 1 Limkain b1 RRM_3 PF08777.9 MSTRG.2562.1_1 - 0.01 15.8 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 1 RNA binding motif RRM_occluded PF16842.3 MSTRG.2562.1_1 - 0.019 14.7 0.0 0.031 14.0 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif RRM_5 PF13893.4 MSTRG.2562.1_1 - 0.039 13.4 0.0 0.072 12.6 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 MSTRG.2562.1_1 - 0.058 13.2 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RAP1 PF07218.9 MSTRG.2562.1_1 - 0.22 9.6 10.4 0.28 9.3 10.4 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Period_C PF12114.6 MSTRG.2562.1_1 - 0.98 8.8 15.7 1.6 8.1 15.7 1.4 1 0 0 1 1 1 0 Period protein 2/3C-terminal region Macoilin PF09726.7 MSTRG.2562.1_1 - 1.6 7.1 11.1 2.4 6.5 11.1 1.3 1 0 0 1 1 1 0 Transmembrane protein FAM199X PF15814.3 MSTRG.2562.1_1 - 2.9 6.7 14.0 4.8 6.0 14.0 1.3 1 0 0 1 1 1 0 Protein family FAM199X Menin PF05053.11 MSTRG.2562.1_1 - 3.8 5.6 7.9 5 5.2 7.9 1.1 1 0 0 1 1 1 0 Menin DNA_topoisoIV PF00521.18 MSTRG.158.1_3 - 3.3e-128 428.1 0.1 6e-128 427.2 0.0 1.5 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.3 MSTRG.158.1_3 - 5.6e-49 165.5 7.2 1.5e-48 164.1 7.2 1.8 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.23 MSTRG.158.1_3 - 1.8e-26 92.5 2.0 4.3e-26 91.3 2.0 1.6 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.24 MSTRG.158.1_3 - 6e-15 55.7 0.0 1.8e-14 54.1 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.20 MSTRG.158.1_3 - 3.8e-09 36.6 0.0 1.1e-08 35.1 0.0 1.8 1 0 0 1 1 1 1 Toprim domain DTHCT PF08070.9 MSTRG.158.1_3 - 4.7e-09 36.8 16.6 4.7e-09 36.8 16.6 5.9 4 1 3 7 7 7 2 DTHCT (NUC029) region FAM176 PF14851.4 MSTRG.158.1_3 - 3.4 7.2 10.7 0.83 9.2 3.2 2.9 2 0 0 2 2 2 0 FAM176 family UPF0029 PF01205.17 MSTRG.23833.1_3 - 2.9e-33 114.2 0.0 6.1e-33 113.2 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.20 MSTRG.23833.1_3 - 1.8e-18 66.8 0.3 3.7e-18 65.8 0.3 1.6 1 0 0 1 1 1 1 RWD domain Ank_2 PF12796.5 MSTRG.13817.1_3 - 1.6e-12 47.7 0.1 3.9e-07 30.4 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.13817.1_3 - 4.3e-11 42.7 0.1 2.2e-08 34.1 0.0 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 MSTRG.13817.1_3 - 8.6e-10 38.8 0.1 0.00058 20.2 0.0 3.4 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.13817.1_3 - 1.2e-08 34.9 3.5 0.00048 20.3 0.0 4.8 5 0 0 5 5 5 1 Ankyrin repeat Ank_3 PF13606.4 MSTRG.13817.1_3 - 1.6e-08 34.0 1.5 0.00068 19.8 0.0 4.7 4 0 0 4 4 4 1 Ankyrin repeat Hox9_act PF04617.11 MSTRG.23057.1_1 - 8.1e-55 186.3 3.9 1.3e-54 185.7 3.9 1.3 1 0 0 1 1 1 1 Hox9 activation region Homeobox PF00046.27 MSTRG.23057.1_1 - 2.7e-20 71.8 6.1 4.4e-20 71.1 6.1 1.3 1 0 0 1 1 1 1 Homeobox domain HTH_23 PF13384.4 MSTRG.23057.1_1 - 0.032 13.9 0.2 0.083 12.6 0.0 1.7 2 0 0 2 2 2 0 Homeodomain-like domain zf-RING_2 PF13639.4 MSTRG.23057.1_1 - 3.2 8.0 7.3 2.1 8.6 4.3 2.2 2 0 0 2 2 2 0 Ring finger domain RasGEF PF00617.17 MSTRG.3298.3_2 - 1.7e-41 142.2 0.2 3e-41 141.3 0.2 1.4 1 0 0 1 1 1 1 RasGEF domain C1_1 PF00130.20 MSTRG.3298.3_2 - 2.3e-13 49.7 10.3 7.3e-13 48.1 10.3 2.0 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_5 PF13202.4 MSTRG.3298.3_2 - 3.8e-13 48.2 3.2 1.8e-06 27.1 0.3 2.6 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.30 MSTRG.3298.3_2 - 3.8e-12 44.7 3.0 7.9e-06 24.9 0.4 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 MSTRG.3298.3_2 - 1.4e-11 43.2 0.7 1.9e-05 24.1 0.2 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.4 MSTRG.3298.3_2 - 3.6e-11 43.2 0.2 2.1e-05 24.8 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.4 MSTRG.3298.3_2 - 9.1e-07 28.4 2.6 0.0008 19.0 0.8 2.7 2 0 0 2 2 2 2 EF-hand domain pair RasGEF_N PF00618.18 MSTRG.3298.3_2 - 1.4e-05 25.1 1.4 0.00056 20.0 0.0 3.7 3 2 0 3 3 3 1 RasGEF N-terminal motif SPARC_Ca_bdg PF10591.7 MSTRG.3298.3_2 - 0.0035 17.5 0.1 5 7.3 0.0 2.8 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region zf-C2H2 PF00096.24 MSTRG.29453.1_2 - 3.5e-10 39.6 14.2 0.00056 20.1 0.7 3.2 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.29453.1_2 - 2.7e-07 30.6 17.5 0.0052 17.0 1.5 3.5 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.29453.1_2 - 5.3e-07 29.8 14.4 0.0043 17.6 1.9 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger Ta0938 PF11494.6 MSTRG.29453.1_2 - 0.0028 17.8 0.2 0.0062 16.7 0.0 1.6 1 1 0 2 2 2 1 Ta0938 zf-met PF12874.5 MSTRG.29453.1_2 - 0.016 15.5 4.6 0.8 10.0 0.1 2.8 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.29453.1_2 - 0.2 11.9 6.4 8.3 6.7 0.2 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding ADH_N PF08240.10 MSTRG.26339.4_3 - 1.3e-06 28.1 0.0 2.3e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.4 MSTRG.26339.4_3 - 9.3e-06 26.6 0.1 3.6e-05 24.7 0.1 1.9 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.24 MSTRG.26339.4_3 - 0.0002 21.1 0.0 0.00037 20.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TPR_14 PF13428.4 MSTRG.22659.2_2 - 6.2e-05 23.3 2.2 0.13 13.1 0.8 3.7 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.22659.2_2 - 0.00094 18.9 0.0 0.0043 16.7 0.0 2.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.22659.2_2 - 0.014 15.8 0.2 0.41 11.1 0.2 2.6 1 1 0 2 2 2 0 Tetratricopeptide repeat NRDE-2 PF08424.8 MSTRG.22659.2_3 - 2.5e-05 23.4 1.0 0.0013 17.8 0.1 2.2 2 0 0 2 2 2 2 NRDE-2, necessary for RNA interference TPR_14 PF13428.4 MSTRG.22659.2_3 - 5.6e-05 23.5 0.0 0.38 11.6 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat Suf PF05843.12 MSTRG.22659.2_3 - 0.081 12.7 0.0 0.081 12.7 0.0 2.4 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) ATP12 PF07542.9 MSTRG.2578.2_1 - 4e-36 123.8 0.0 6.2e-36 123.2 0.0 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein GDE_C PF06202.12 MSTRG.12888.3_1 - 3.6e-133 444.1 0.0 4.8e-133 443.7 0.0 1.1 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.4 MSTRG.12888.3_1 - 3.6e-60 203.7 0.0 5.6e-60 203.1 0.0 1.2 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_central PF14702.4 MSTRG.12888.3_2 - 0.094 12.2 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Central domain of human glycogen debranching enzyme zf-MYND PF01753.16 MSTRG.12888.3_3 - 0.0068 16.4 0.0 0.05 13.6 0.0 2.6 1 1 0 1 1 1 1 MYND finger RTP801_C PF07809.9 MSTRG.1512.1_3 - 2.6e-37 127.4 0.0 3.9e-37 126.8 0.0 1.2 1 0 0 1 1 1 1 RTP801 C-terminal region Adaptin_N PF01602.18 MSTRG.23696.8_2 - 3.5e-53 180.8 4.5 5e-53 180.3 4.5 1.1 1 0 0 1 1 1 1 Adaptin N terminal region AP3D1 PF06375.9 MSTRG.23696.8_2 - 3.8e-49 166.9 54.5 2e-47 161.3 15.5 3.4 3 0 0 3 3 3 3 AP-3 complex subunit delta-1 RasGEF_N_2 PF14663.4 MSTRG.23696.8_2 - 0.056 13.7 0.3 0.14 12.4 0.3 1.6 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain HEAT PF02985.20 MSTRG.23696.8_2 - 0.066 13.4 0.1 1.1 9.5 0.0 2.7 2 0 0 2 2 2 0 HEAT repeat RTP1_C1 PF10363.7 MSTRG.23696.8_2 - 0.1 12.6 2.4 2.4 8.2 0.5 2.5 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF3807 PF12720.5 MSTRG.23696.8_2 - 0.83 9.8 38.7 0.76 9.9 6.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3807) SR-25 PF10500.7 MSTRG.23696.8_2 - 3.7 7.0 62.2 0.013 15.0 9.7 4.2 3 1 0 3 3 3 0 Nuclear RNA-splicing-associated protein DUF758 PF05527.9 MSTRG.8433.3_2 - 7.7e-38 130.1 0.7 1.1e-37 129.7 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF758) Band_7 PF01145.23 MSTRG.23296.1_2 - 3.8e-21 75.8 0.1 3.8e-21 75.8 0.1 2.7 1 1 0 2 2 2 1 SPFH domain / Band 7 family Flot PF15975.3 MSTRG.23296.1_2 - 0.00016 21.7 7.9 0.00016 21.7 7.9 4.0 2 2 1 3 3 3 2 Flotillin HECT PF00632.23 MSTRG.20255.1_3 - 2.6e-05 23.7 0.0 3.8e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IF3_N PF05198.14 MSTRG.2730.1_1 - 0.06 13.5 0.1 0.098 12.8 0.1 1.3 1 0 0 1 1 1 0 Translation initiation factor IF-3, N-terminal domain COesterase PF00135.26 MSTRG.2730.1_2 - 2.4e-118 396.1 0.0 2.9e-118 395.9 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 MSTRG.2730.1_2 - 0.00087 19.0 0.0 0.0015 18.2 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 MSTRG.2730.1_2 - 0.05 13.0 0.0 0.083 12.2 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family SPOC PF07744.11 MSTRG.20364.1_1 - 2.3e-27 95.6 0.0 4.2e-27 94.8 0.0 1.4 1 0 0 1 1 1 1 SPOC domain TFIIS_M PF07500.12 MSTRG.20364.1_1 - 2.4e-20 72.9 0.2 7.5e-20 71.3 0.2 1.8 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain SlyX PF04102.10 MSTRG.20364.1_1 - 0.031 14.8 3.4 0.098 13.2 3.4 1.9 1 0 0 1 1 1 0 SlyX IncA PF04156.12 MSTRG.20364.1_1 - 0.065 12.9 2.9 0.2 11.3 2.2 2.1 2 0 0 2 2 2 0 IncA protein UPF0449 PF15136.4 MSTRG.20364.1_1 - 0.53 10.7 5.8 0.63 10.4 0.4 3.4 3 0 0 3 3 3 0 Uncharacterised protein family UPF0449 ZapB PF06005.10 MSTRG.20364.1_1 - 0.85 10.0 8.6 2.3 8.6 8.6 1.7 1 0 0 1 1 1 0 Cell division protein ZapB FAM76 PF16046.3 MSTRG.20364.1_1 - 4 6.6 14.7 42 3.2 0.1 3.0 2 0 0 2 2 2 0 FAM76 protein COX8 PF02285.13 MSTRG.18761.1_2 - 1.1e-19 69.9 0.0 1.8e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIII NAT PF04768.11 MSTRG.16344.1_1 - 2e-44 151.1 0.2 3.2e-44 150.4 0.2 1.3 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase AA_kinase PF00696.26 MSTRG.16344.1_1 - 0.00075 19.0 0.0 0.0027 17.2 0.0 1.9 1 1 0 1 1 1 1 Amino acid kinase family Acetyltransf_10 PF13673.5 MSTRG.16344.1_1 - 0.042 13.7 0.0 0.085 12.7 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.5 MSTRG.16344.1_1 - 0.063 13.6 0.0 0.18 12.1 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain PRK PF00485.16 MSTRG.15048.5_2 - 6e-23 81.5 0.0 7.6e-23 81.2 0.0 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family CPT PF07931.10 MSTRG.15048.5_2 - 1e-06 28.6 0.0 1.4e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_33 PF13671.4 MSTRG.15048.5_2 - 5.9e-05 23.1 0.0 7.5e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 MSTRG.15048.5_2 - 0.0042 17.4 0.0 0.0056 17.1 0.0 1.1 1 0 0 1 1 1 1 AAA domain CoaE PF01121.18 MSTRG.15048.5_2 - 0.0065 16.0 0.0 0.0082 15.7 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase Zeta_toxin PF06414.10 MSTRG.15048.5_2 - 0.035 13.3 0.0 0.047 12.9 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin MobB PF03205.12 MSTRG.15048.5_2 - 0.098 12.4 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_17 PF13207.4 MSTRG.15048.5_2 - 0.11 12.8 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain 6PF2K PF01591.16 MSTRG.15048.5_2 - 0.14 11.3 0.0 0.21 10.7 0.0 1.3 1 1 0 1 1 1 0 6-phosphofructo-2-kinase SH2 PF00017.22 MSTRG.27183.1_3 - 0.14 12.1 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 SH2 domain Kinesin PF00225.21 MSTRG.9312.1_2 - 1.3e-111 372.6 0.6 1.3e-111 372.6 0.6 1.7 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.3 MSTRG.9312.1_2 - 3.3e-27 95.1 0.9 9.1e-27 93.7 0.0 2.2 2 0 0 2 2 2 1 Microtubule binding Reo_sigmaC PF04582.10 MSTRG.9312.1_2 - 7.9 5.6 16.0 1.6 7.9 1.7 3.2 2 1 1 3 3 3 0 Reovirus sigma C capsid protein Lig_chan PF00060.24 MSTRG.3839.1_3 - 7.6e-60 200.9 0.0 1.2e-59 200.3 0.0 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 MSTRG.3839.1_3 - 1.8e-17 63.4 0.0 2.9e-17 62.7 0.0 1.3 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 MSTRG.3839.1_3 - 3.3e-17 62.5 0.0 4.9e-17 62.0 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 DUF2061 PF09834.7 MSTRG.3839.1_3 - 0.07 13.5 0.4 0.27 11.6 0.4 2.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2061) ANAPC5 PF12862.5 MSTRG.2963.1_1 - 7.4e-28 96.3 13.6 7.7e-27 93.1 1.9 4.0 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 5 TPR_12 PF13424.4 MSTRG.2963.1_1 - 0.0074 16.4 9.6 0.68 10.1 0.5 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.2963.1_1 - 2.2 8.3 7.1 20 5.3 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat HMMR_N PF15905.3 MSTRG.16023.1_3 - 1.7e-97 326.8 40.5 1.7e-97 326.8 40.5 6.7 1 1 8 9 9 9 1 Hyaluronan mediated motility receptor N-terminal HMMR_C PF15908.3 MSTRG.16023.1_3 - 7.3e-59 198.4 20.5 7.3e-59 198.4 20.5 8.1 2 2 5 8 8 8 1 Hyaluronan mediated motility receptor C-terminal GATase_7 PF13537.4 MSTRG.16023.1_3 - 0.063 13.1 0.9 0.21 11.4 0.2 2.4 2 0 0 2 2 2 0 Glutamine amidotransferase domain Metalloenzyme PF01676.16 MSTRG.16023.1_3 - 1 8.5 3.4 2.8 7.1 3.4 1.7 1 0 0 1 1 1 0 Metalloenzyme superfamily PBD PF00786.26 MSTRG.2131.1_2 - 0.00015 22.0 0.1 0.00033 20.9 0.1 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain AAA PF00004.27 MSTRG.21417.1_2 - 5.2e-47 159.4 0.0 5.9e-41 139.9 0.0 3.7 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) Bromodomain PF00439.23 MSTRG.21417.1_2 - 2.7e-20 72.1 0.1 9.1e-20 70.4 0.1 2.0 1 0 0 1 1 1 1 Bromodomain AAA_16 PF13191.4 MSTRG.21417.1_2 - 5e-06 26.9 0.4 0.0012 19.2 0.0 3.5 3 0 0 3 3 3 1 AAA ATPase domain AAA_2 PF07724.12 MSTRG.21417.1_2 - 3e-05 24.1 0.0 0.00011 22.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.15 MSTRG.21417.1_2 - 8.8e-05 22.2 0.0 0.00039 20.1 0.0 2.0 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_5 PF07728.12 MSTRG.21417.1_2 - 0.0096 15.8 0.1 0.16 11.8 0.0 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.20 MSTRG.21417.1_2 - 0.0099 16.1 0.0 0.05 13.9 0.0 2.3 2 0 0 2 2 2 1 RNA helicase AAA_18 PF13238.4 MSTRG.21417.1_2 - 0.014 15.8 0.0 0.014 15.8 0.0 3.8 4 0 0 4 4 3 0 AAA domain RuvB_N PF05496.10 MSTRG.21417.1_2 - 0.017 14.2 0.0 0.092 11.9 0.0 2.2 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus Polyoma_lg_T_C PF06431.9 MSTRG.21417.1_2 - 0.034 12.9 4.1 0.45 9.2 4.0 2.2 2 0 0 2 2 2 0 Polyomavirus large T antigen C-terminus Mg_chelatase PF01078.19 MSTRG.21417.1_2 - 0.069 12.4 0.0 0.4 9.9 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_22 PF13401.4 MSTRG.21417.1_2 - 0.12 12.6 11.1 0.15 12.2 0.1 5.5 6 2 0 7 7 6 0 AAA domain ABC_tran PF00005.25 MSTRG.21417.1_2 - 0.78 10.1 7.5 5.3 7.4 0.0 4.2 4 0 0 4 4 4 0 ABC transporter Trypsin PF00089.24 MSTRG.27994.1_1 - 2e-58 197.7 0.2 2.6e-58 197.3 0.2 1.1 1 0 0 1 1 1 1 Trypsin zf-C3HC PF07967.11 MSTRG.28041.1_2 - 0.12 12.2 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 C3HC zinc finger-like PP2C PF00481.19 MSTRG.17343.1_2 - 1.5e-07 31.2 0.0 2e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C zf-H2C2_2 PF13465.4 MSTRG.291.1_1 - 2.8e-21 74.8 22.2 9.5e-07 28.9 0.6 5.5 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.291.1_1 - 3.3e-16 58.6 38.3 1.2e-05 25.3 1.6 5.3 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.291.1_1 - 9.5e-05 22.8 9.1 0.0013 19.2 1.1 6.3 6 0 0 6 6 6 4 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 MSTRG.291.1_1 - 0.011 15.7 9.1 0.032 14.2 0.6 3.3 1 1 2 3 3 3 0 Zinc ribbon domain Elf1 PF05129.11 MSTRG.291.1_1 - 0.013 15.4 0.8 0.013 15.4 0.8 3.3 3 1 1 4 4 4 0 Transcription elongation factor Elf1 like zf-C2HC_2 PF13913.4 MSTRG.291.1_1 - 0.04 13.7 9.4 0.06 13.1 0.6 3.6 3 0 0 3 3 3 0 zinc-finger of a C2HC-type DUF3268 PF11672.6 MSTRG.291.1_1 - 0.042 14.1 9.4 0.65 10.2 0.3 3.0 3 0 0 3 3 3 0 zinc-finger-containing domain zf-LYAR PF08790.9 MSTRG.291.1_1 - 0.077 12.8 19.6 3.8 7.4 5.0 4.7 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger zf-met PF12874.5 MSTRG.291.1_1 - 3 8.2 15.4 3 8.2 0.6 4.4 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2HE PF16278.3 MSTRG.291.1_1 - 6.7 7.1 13.0 1.9 8.9 0.5 3.9 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger DUF3585 PF12130.6 MSTRG.8148.4_2 - 8.4e-39 132.7 27.0 2.1e-38 131.4 27.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3585) CH PF00307.29 MSTRG.8148.4_2 - 2.1e-21 76.0 0.0 4.6e-21 74.9 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain NT-C2 PF10358.7 MSTRG.8148.4_2 - 7.4e-19 67.8 1.6 8e-19 67.7 0.3 1.8 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins CAMSAP_CH PF11971.6 MSTRG.8148.4_2 - 0.0022 17.7 0.0 0.0049 16.5 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain Ank_4 PF13637.4 MSTRG.21675.1_2 - 4.4e-12 46.1 0.6 8.9e-07 29.2 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 MSTRG.21675.1_2 - 5.2e-12 46.1 0.3 1.1e-11 45.0 0.4 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.21675.1_2 - 5.6e-11 42.4 0.3 3.6e-09 36.6 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.21675.1_2 - 3.9e-08 33.3 0.1 0.00052 20.2 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.4 MSTRG.21675.1_2 - 1.1e-07 31.4 0.2 0.00038 20.6 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat WW PF00397.24 MSTRG.54.2_1 - 1.8e-19 69.2 0.7 8.6e-10 38.3 0.1 2.6 2 0 0 2 2 2 2 WW domain C2 PF00168.28 MSTRG.54.2_1 - 0.0019 18.3 0.0 0.0038 17.4 0.0 1.5 1 0 0 1 1 1 1 C2 domain DUF2203 PF09969.7 MSTRG.54.2_1 - 4 8.0 11.1 2.6 8.6 0.0 3.9 3 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) SH3_1 PF00018.26 MSTRG.25014.2_2 - 1.1e-08 34.4 0.0 2.2e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.25014.2_2 - 5.2e-08 32.5 0.0 9.7e-08 31.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.25014.2_2 - 3.9e-05 23.1 0.0 6.7e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 MSTRG.25014.2_2 - 0.0098 16.0 0.2 0.018 15.2 0.2 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain hSH3 PF14603.4 MSTRG.25014.2_2 - 0.052 13.9 0.1 0.37 11.2 0.0 2.1 2 0 0 2 2 2 0 Helically-extended SH3 domain Ank_4 PF13637.4 MSTRG.22158.1_2 - 2.9e-21 75.4 0.1 1e-07 32.2 0.0 4.1 2 1 3 5 5 5 4 Ankyrin repeats (many copies) BTB PF00651.29 MSTRG.22158.1_2 - 5.2e-21 74.8 0.2 2.7e-20 72.5 0.3 2.1 2 0 0 2 2 2 1 BTB/POZ domain Ank_2 PF12796.5 MSTRG.22158.1_2 - 4.2e-20 72.0 0.0 2.7e-10 40.5 0.0 3.8 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.4 MSTRG.22158.1_2 - 4.3e-19 66.5 0.1 2.9e-05 24.0 0.0 5.0 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.28 MSTRG.22158.1_2 - 3.6e-16 58.7 1.2 2.3e-06 27.7 0.0 4.4 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.4 MSTRG.22158.1_2 - 1.4e-15 57.0 0.3 0.0024 18.1 0.0 4.5 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Glyco_transf_29 PF00777.16 MSTRG.8729.1_1 - 2.2e-35 122.2 1.2 3e-35 121.8 1.2 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) WD40 PF00400.30 MSTRG.13231.1_3 - 4.1e-06 27.3 3.5 0.0048 17.6 0.0 2.6 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.13231.1_3 - 0.014 15.6 0.1 1.7 8.9 0.0 2.0 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain CPCFC PF17223.1 MSTRG.22809.1_1 - 0.11 12.2 1.6 0.33 10.6 1.6 1.9 1 0 0 1 1 1 0 Cuticle protein CPCFC MAM33 PF02330.14 MSTRG.22809.1_3 - 2.2e-34 119.1 4.3 2.8e-34 118.7 4.3 1.1 1 0 0 1 1 1 1 Mitochondrial glycoprotein Tim44 PF04280.13 MSTRG.4070.3_2 - 1.2e-31 109.7 0.0 1.7e-31 109.1 0.0 1.3 1 0 0 1 1 1 1 Tim44-like domain p450 PF00067.20 MSTRG.20418.1_1 - 2.1e-42 145.3 0.0 3.2e-42 144.7 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 FixQ PF05545.9 MSTRG.20418.1_1 - 0.32 10.9 2.4 0.49 10.3 0.3 2.3 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ 2-Hacid_dh_C PF02826.17 MSTRG.6114.1_1 - 1.7e-56 190.2 0.0 3e-56 189.5 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.13 MSTRG.6114.1_1 - 1.9e-07 31.3 0.0 3e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.15 MSTRG.6114.1_1 - 0.00059 20.2 0.0 0.001 19.5 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent PDH PF02153.15 MSTRG.6114.1_1 - 0.054 12.4 0.0 0.076 11.9 0.0 1.1 1 0 0 1 1 1 0 Prephenate dehydrogenase AlaDh_PNT_C PF01262.19 MSTRG.6114.1_1 - 0.065 12.4 0.1 0.13 11.5 0.1 1.4 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain HTH_WhiA PF02650.12 MSTRG.7103.1_2 - 0.12 12.6 0.1 0.14 12.3 0.1 1.1 1 0 0 1 1 1 0 WhiA C-terminal HTH domain Ank_2 PF12796.5 MSTRG.2485.1_3 - 6.3e-15 55.4 1.1 1.5e-06 28.5 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.2485.1_3 - 2.9e-12 46.7 0.4 0.00088 19.7 0.0 4.9 3 2 2 5 5 5 3 Ankyrin repeats (many copies) SOCS_box PF07525.14 MSTRG.2485.1_3 - 2.4e-11 43.7 5.1 4.9e-11 42.6 5.1 1.6 1 0 0 1 1 1 1 SOCS box Ank_3 PF13606.4 MSTRG.2485.1_3 - 7e-11 41.2 1.7 0.0055 17.0 0.2 5.3 5 1 0 5 5 5 2 Ankyrin repeat Ank PF00023.28 MSTRG.2485.1_3 - 1.7e-10 40.7 9.1 0.0068 16.7 0.6 5.5 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.4 MSTRG.2485.1_3 - 2.1e-10 40.5 7.1 3.1e-06 27.3 0.6 3.5 2 1 0 2 2 2 2 Ankyrin repeats (many copies) ubiquitin PF00240.21 MSTRG.2485.1_3 - 4.9e-09 35.7 0.6 9.4e-09 34.7 0.6 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.4 MSTRG.2485.1_3 - 0.062 13.3 0.1 0.19 11.7 0.1 1.8 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like SKG6 PF08693.8 MSTRG.2485.1_3 - 0.43 9.9 3.8 0.96 8.8 3.8 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain MtrG PF04210.11 MSTRG.9950.2_1 - 0.17 11.6 0.0 0.38 10.5 0.0 1.5 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G Arginase PF00491.19 MSTRG.10122.1_1 - 3.2e-69 233.4 0.1 4.1e-69 233.1 0.1 1.1 1 0 0 1 1 1 1 Arginase family Adhesin_E PF16747.3 MSTRG.10122.1_3 - 0.13 12.2 0.4 21 5.0 0.1 2.2 2 0 0 2 2 2 0 Surface-adhesin protein E DUF3361 PF11841.6 MSTRG.2830.1_2 - 6.2e-51 172.3 1.3 1.2e-50 171.4 1.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) ELMO_CED12 PF04727.11 MSTRG.2830.1_2 - 6.5e-42 143.5 1.1 9.7e-42 142.9 1.1 1.3 1 0 0 1 1 1 1 ELMO/CED-12 family PH_12 PF16457.3 MSTRG.2830.1_2 - 1e-38 132.7 0.0 2.3e-38 131.6 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain SAP PF02037.25 MSTRG.25689.3_3 - 1.8e-06 27.4 0.3 3.4e-06 26.6 0.3 1.4 1 0 0 1 1 1 1 SAP domain Glyco_transf_10 PF00852.17 MSTRG.7386.1_2 - 6.3e-34 117.1 0.0 1.2e-33 116.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.3 MSTRG.7386.1_2 - 4.6e-12 46.2 0.0 1e-11 45.1 0.0 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal SPRY PF00622.26 MSTRG.12949.1_3 - 0.00019 21.4 0.0 0.00027 20.9 0.0 1.2 1 0 0 1 1 1 1 SPRY domain COQ9 PF08511.9 MSTRG.14341.1_2 - 0.061 13.0 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 COQ9 Gal_Lectin PF02140.16 MSTRG.25136.2_1 - 1.5e-31 108.5 11.9 1.1e-18 67.3 2.2 2.4 2 0 0 2 2 2 2 Galactose binding lectin domain PDZ PF00595.22 MSTRG.15215.1_3 - 1.1e-62 208.2 6.9 1.4e-14 54.0 0.0 6.4 6 0 0 6 6 6 6 PDZ domain (Also known as DHR or GLGF) MAGI_u1 PF16663.3 MSTRG.15215.1_3 - 2.2e-24 85.0 2.0 8.4e-24 83.2 2.0 2.1 1 0 0 1 1 1 1 Unstructured region on MAGI PDZ_2 PF13180.4 MSTRG.15215.1_3 - 2.6e-24 85.2 0.6 0.00072 19.7 0.0 6.4 6 0 0 6 6 6 5 PDZ domain WW PF00397.24 MSTRG.15215.1_3 - 3e-16 58.9 3.5 9.7e-10 38.1 0.3 2.6 2 0 0 2 2 2 2 WW domain Guanylate_kin PF00625.19 MSTRG.15215.1_3 - 4.1e-10 39.5 0.0 7.4e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase Tricorn_PDZ PF14685.4 MSTRG.15215.1_3 - 8.6e-06 25.6 6.0 1.2 9.1 0.1 5.7 6 0 0 6 6 6 2 Tricorn protease PDZ domain DUF4604 PF15377.4 MSTRG.15215.1_3 - 0.014 15.7 0.7 0.014 15.7 0.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) Ras PF00071.20 MSTRG.8132.1_3 - 9e-46 155.3 0.0 1.2e-45 154.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.8132.1_3 - 1.3e-31 109.2 0.0 1.9e-31 108.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.8132.1_3 - 1.2e-12 47.5 0.0 1.9e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 MSTRG.8132.1_3 - 5.4e-06 26.3 0.0 7.6e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 MSTRG.8132.1_3 - 0.00037 19.8 0.0 0.00055 19.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.4 MSTRG.8132.1_3 - 0.047 13.8 0.0 0.51 10.5 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.4 MSTRG.8132.1_3 - 0.066 13.2 0.0 0.093 12.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain DDE_Tnp_1_7 PF13843.4 MSTRG.19078.1_3 - 2.4e-78 263.7 0.0 3.5e-78 263.2 0.0 1.2 1 0 0 1 1 1 1 Transposase IS4 DDE_Tnp_1 PF01609.19 MSTRG.19078.1_3 - 0.026 14.1 0.0 0.082 12.4 0.0 1.8 2 0 0 2 2 2 0 Transposase DDE domain Siva PF05458.10 MSTRG.19078.1_3 - 0.084 12.4 9.4 0.18 11.4 9.4 1.4 1 0 0 1 1 1 0 Cd27 binding protein (Siva) Radial_spoke PF04712.10 MSTRG.19078.1_3 - 1.8 7.3 13.4 2.7 6.7 13.4 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein BUD22 PF09073.8 MSTRG.19078.1_3 - 1.9 7.6 11.2 2.9 7.0 11.2 1.2 1 0 0 1 1 1 0 BUD22 Tim54 PF11711.6 MSTRG.19078.1_3 - 2.1 6.9 5.7 3.2 6.3 5.7 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SDA1 PF05285.10 MSTRG.19078.1_3 - 8.9 5.5 17.2 14 4.9 17.2 1.2 1 0 0 1 1 1 0 SDA1 MOSC_N PF03476.14 MSTRG.14710.1_1 - 0.05 13.4 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 MOSC N-terminal beta barrel domain MOSC_N PF03476.14 MSTRG.14710.1_2 - 2.1e-09 37.2 0.0 3.2e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain DUF2556 PF10831.6 MSTRG.9324.1_1 - 1.6 8.6 5.7 37 4.2 3.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2556) PDZ PF00595.22 MSTRG.4838.1_1 - 4.7e-09 36.3 0.1 0.00023 21.3 0.0 2.6 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) YebO PF13974.4 MSTRG.4838.1_1 - 0.31 11.0 0.0 0.31 11.0 0.0 2.5 2 0 0 2 2 2 0 YebO-like protein Tropomyosin PF00261.18 MSTRG.24844.2_1 - 4.4e-92 307.6 58.9 4.4e-92 307.6 58.9 2.0 1 1 1 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.5 MSTRG.24844.2_1 - 8.3e-38 129.6 70.3 4.4e-34 117.5 39.6 2.9 1 1 0 2 2 2 2 Tropomyosin like CLZ PF16526.3 MSTRG.24844.2_1 - 9.9e-10 38.5 45.5 1.5e-06 28.3 10.7 4.7 2 2 2 4 4 4 4 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Laminin_II PF06009.10 MSTRG.24844.2_1 - 4.8e-06 26.5 34.0 0.00092 19.1 8.2 3.5 1 1 2 3 3 3 2 Laminin Domain II XhlA PF10779.7 MSTRG.24844.2_1 - 0.0026 17.8 49.3 0.022 14.8 3.0 5.9 2 1 4 6 6 6 4 Haemolysin XhlA BST2 PF16716.3 MSTRG.24844.2_1 - 0.014 15.8 6.7 0.014 15.8 6.7 4.9 1 1 5 6 6 5 0 Bone marrow stromal antigen 2 IncA PF04156.12 MSTRG.24844.2_1 - 0.067 12.8 56.1 0.072 12.7 23.7 2.7 1 1 2 3 3 3 0 IncA protein ADIP PF11559.6 MSTRG.24844.2_1 - 0.12 12.3 47.6 0.28 11.1 6.3 4.2 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding FbpA PF05833.9 MSTRG.24844.2_1 - 0.14 10.8 32.3 0.2 10.3 32.3 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) Reo_sigmaC PF04582.10 MSTRG.24844.2_1 - 0.15 11.3 10.6 0.066 12.5 2.2 2.2 1 1 0 2 2 2 0 Reovirus sigma C capsid protein CENP-F_leu_zip PF10473.7 MSTRG.24844.2_1 - 0.16 11.9 64.0 0.44 10.4 31.0 2.5 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MscS_porin PF12795.5 MSTRG.24844.2_1 - 0.64 9.4 44.4 4.2 6.7 10.0 3.0 1 1 2 3 3 3 0 Mechanosensitive ion channel porin domain Lebercilin PF15619.4 MSTRG.24844.2_1 - 0.68 9.4 63.0 7.1 6.1 29.3 3.2 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease APG6 PF04111.10 MSTRG.24844.2_1 - 0.85 8.8 60.1 0.21 10.8 12.7 3.2 1 1 3 4 4 4 0 Autophagy protein Apg6 Golgin_A5 PF09787.7 MSTRG.24844.2_1 - 0.88 8.8 52.0 1.6 8.0 23.3 2.3 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF1664 PF07889.10 MSTRG.24844.2_1 - 1.2 9.0 30.6 0.1 12.5 3.3 3.9 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) TMF_DNA_bd PF12329.6 MSTRG.24844.2_1 - 1.2 9.1 62.9 0.056 13.3 12.2 6.3 1 1 4 6 6 6 0 TATA element modulatory factor 1 DNA binding LOH1CR12 PF10158.7 MSTRG.24844.2_1 - 1.4 8.8 9.9 0.71 9.8 0.8 2.9 2 1 0 2 2 2 0 Tumour suppressor protein DUF745 PF05335.11 MSTRG.24844.2_1 - 1.4 8.5 46.4 0.55 9.8 14.9 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF745) DUF3450 PF11932.6 MSTRG.24844.2_1 - 1.9 7.6 48.8 0.019 14.1 6.5 3.9 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) AAA_13 PF13166.4 MSTRG.24844.2_1 - 2.4 6.6 44.3 8.4 4.8 25.8 2.2 1 1 1 2 2 2 0 AAA domain ATG16 PF08614.9 MSTRG.24844.2_1 - 2.7 8.0 60.8 0.018 15.1 19.5 3.5 1 1 1 2 2 1 0 Autophagy protein 16 (ATG16) ERM PF00769.17 MSTRG.24844.2_1 - 3 7.5 69.9 2.8 7.6 18.6 3.0 1 1 2 3 3 3 0 Ezrin/radixin/moesin family MAD PF05557.11 MSTRG.24844.2_1 - 5.3 5.1 56.5 13 3.8 27.8 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein Laminin_I PF06008.12 MSTRG.24844.2_1 - 5.5 6.5 52.2 1.2 8.6 14.9 3.1 1 1 2 3 3 3 0 Laminin Domain I Exonuc_VII_L PF02601.13 MSTRG.24844.2_1 - 9.5 5.5 35.0 28 4.0 13.8 2.3 1 1 1 2 2 2 0 Exonuclease VII, large subunit I-set PF07679.14 MSTRG.4848.1_3 - 1.1e-11 44.5 0.0 1.1e-09 38.1 0.0 2.6 3 0 0 3 3 3 1 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.4848.1_3 - 5.8e-11 42.7 2.6 6.5e-06 26.5 0.0 3.4 4 0 0 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.4848.1_3 - 1.9e-10 40.8 0.5 1.5e-05 25.1 0.0 3.0 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 MSTRG.4848.1_3 - 0.0014 18.6 0.2 1.3 9.0 0.0 3.4 3 1 0 3 3 3 1 Immunoglobulin V-set domain ig PF00047.23 MSTRG.4848.1_3 - 0.0018 18.3 0.0 0.21 11.7 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.10 MSTRG.4848.1_3 - 0.0029 17.5 0.1 0.0098 15.8 0.0 1.9 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain DUF2141 PF09912.7 MSTRG.4848.1_3 - 0.12 12.2 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2141) VEFS-Box PF09733.7 MSTRG.19484.2_1 - 3.1e-50 169.4 1.1 3.1e-50 169.4 1.1 2.0 2 0 0 2 2 2 1 VEFS-Box of polycomb protein Pkinase PF00069.23 MSTRG.10322.1_2 - 5.9e-49 166.7 0.2 8e-49 166.2 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.10322.1_2 - 6.8e-22 77.9 0.2 3.1e-21 75.7 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase EP400_N PF15790.3 MSTRG.2941.2_3 - 5.9e-271 899.3 41.7 5.9e-271 899.3 41.7 6.3 4 2 1 6 6 6 1 E1A-binding protein p400, N-terminal SNF2_N PF00176.21 MSTRG.2941.2_3 - 3.6e-50 170.5 5.6 9.5e-50 169.1 5.6 1.7 1 0 0 1 1 1 1 SNF2 family N-terminal domain HSA PF07529.11 MSTRG.2941.2_3 - 6.5e-19 67.9 9.4 6.5e-19 67.9 9.4 3.4 2 0 0 2 2 2 1 HSA Helicase_C PF00271.29 MSTRG.2941.2_3 - 9.1e-08 32.3 0.1 6.1e-07 29.7 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.2941.2_3 - 6.9e-05 22.8 0.0 0.00034 20.5 0.0 2.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.6 MSTRG.2941.2_3 - 0.00049 19.2 4.9 0.005 15.9 0.1 3.0 3 0 0 3 3 3 2 Class II histone deacetylase complex subunits 2 and 3 Myb_DNA-bind_4 PF13837.4 MSTRG.2941.2_3 - 0.00051 20.3 2.1 0.0018 18.5 0.0 2.9 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Myb_DNA-binding PF00249.29 MSTRG.2941.2_3 - 0.0011 19.0 0.0 0.0029 17.6 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 MSTRG.2941.2_3 - 0.0012 18.9 0.1 0.0064 16.6 0.1 2.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Neurexophilin PF06312.10 MSTRG.22299.1_2 - 1.7e-11 43.8 0.1 2.6e-11 43.2 0.1 1.3 1 0 0 1 1 1 1 Neurexophilin P33MONOX PF15302.4 MSTRG.1014.2_2 - 3e-94 315.9 2.8 4.2e-94 315.4 2.8 1.1 1 0 0 1 1 1 1 P33 mono-oxygenase P33MONOX PF15302.4 MSTRG.1014.2_3 - 4.1e-27 95.5 0.1 6.2e-27 94.9 0.1 1.2 1 0 0 1 1 1 1 P33 mono-oxygenase OST-HTH PF12872.5 MSTRG.29255.1_1 - 8e-06 25.6 0.1 0.016 15.0 0.0 2.2 2 0 0 2 2 2 2 OST-HTH/LOTUS domain DUF1910 PF08928.8 MSTRG.29255.1_1 - 0.017 15.0 0.0 5 7.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1910) Rubella_Capsid PF05750.9 MSTRG.29255.1_1 - 3.8 6.9 8.5 4.6 6.6 8.5 1.1 1 0 0 1 1 1 0 Rubella capsid protein SNF PF00209.16 MSTRG.10802.1_2 - 1.3e-170 568.5 28.0 1.7e-170 568.1 28.0 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family EF-hand_7 PF13499.4 MSTRG.1978.2_1 - 3.9e-22 78.4 2.2 2.3e-16 59.9 0.2 3.0 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.30 MSTRG.1978.2_1 - 3.9e-19 66.6 7.2 1.5e-07 30.3 0.1 3.8 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.4 MSTRG.1978.2_1 - 7.2e-17 59.7 5.6 3.5e-05 23.3 0.0 4.7 4 1 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.4 MSTRG.1978.2_1 - 1.6e-13 49.3 4.7 2.3e-05 23.6 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.4 MSTRG.1978.2_1 - 5.9e-13 48.2 3.3 6.2e-05 22.5 0.2 3.7 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.5 MSTRG.1978.2_1 - 0.00011 22.0 1.0 0.027 14.3 0.1 2.7 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 MSTRG.1978.2_1 - 0.0003 21.0 3.5 0.0013 18.9 0.4 3.1 3 1 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_2 PF09068.9 MSTRG.1978.2_1 - 0.12 12.4 0.0 4.1 7.4 0.0 2.4 2 0 0 2 2 2 0 EF hand Toxin_1 PF00087.19 MSTRG.4897.1_1 - 0.0062 16.6 10.9 0.0062 16.6 10.9 1.7 2 0 0 2 2 2 1 Snake toxin DUF2909 PF11137.6 MSTRG.4897.1_1 - 0.068 13.0 0.4 0.097 12.5 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2909) G-patch PF01585.21 MSTRG.14016.3_2 - 1.3e-17 63.3 2.9 2.7e-17 62.3 2.9 1.6 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.20 MSTRG.14016.3_2 - 4.2e-15 55.2 0.0 1.5e-06 27.8 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP PF00641.16 MSTRG.14016.3_2 - 2.7e-10 39.2 1.5 6.2e-10 38.1 1.5 1.7 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others G-patch_2 PF12656.5 MSTRG.14016.3_2 - 1.8e-07 31.0 0.6 1.8e-07 31.0 0.6 2.1 2 0 0 2 2 2 1 G-patch domain zf-C2H2_jaz PF12171.6 MSTRG.14016.3_2 - 0.057 13.6 0.1 0.14 12.4 0.1 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.4 MSTRG.14016.3_2 - 0.071 13.8 0.1 0.26 12.1 0.1 2.1 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2HE PF16278.3 MSTRG.14016.3_2 - 0.095 13.0 0.3 3.3 8.1 0.3 3.1 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2 PF00096.24 MSTRG.14016.3_2 - 2.5 8.6 5.9 0.39 11.1 0.2 2.8 2 1 1 3 3 3 0 Zinc finger, C2H2 type bZIP_1 PF00170.19 MSTRG.9039.1_3 - 1.9e-12 46.9 10.0 4.5e-12 45.8 10.0 1.7 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 MSTRG.9039.1_3 - 5e-09 36.0 6.1 1.1e-08 34.9 6.1 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 MSTRG.9039.1_3 - 0.0011 19.3 8.4 0.002 18.5 8.4 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor GIT_CC PF16559.3 MSTRG.9039.1_3 - 1 9.3 3.9 2.2 8.2 3.9 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor ZapB PF06005.10 MSTRG.9039.1_3 - 1.2 9.5 7.0 0.16 12.3 0.5 2.7 3 0 0 3 3 3 0 Cell division protein ZapB Oscp1 PF10188.7 MSTRG.15365.1_1 - 4.4e-70 235.2 5.8 6e-70 234.8 5.8 1.2 1 0 0 1 1 1 1 Organic solute transport protein 1 LSM PF01423.20 MSTRG.15365.1_2 - 8.3e-12 44.5 0.4 1.3e-11 43.9 0.4 1.3 1 0 0 1 1 1 1 LSM domain SH3_9 PF14604.4 MSTRG.14726.1_3 - 3.7e-39 132.2 0.2 5.6e-15 54.8 0.0 3.7 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.26 MSTRG.14726.1_3 - 8.8e-38 127.6 0.1 5.8e-12 44.9 0.0 3.7 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.15 MSTRG.14726.1_3 - 1.1e-28 98.5 0.6 2.4e-11 43.0 0.0 3.6 3 0 0 3 3 3 3 Variant SH3 domain Sorb PF02208.14 MSTRG.14726.1_3 - 3.9e-09 35.9 0.0 1.1e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 Sorbin homologous domain GLTSCR1 PF15249.4 MSTRG.27155.2_1 - 2.8e-29 101.4 0.8 2.8e-29 101.4 0.8 1.8 2 0 0 2 2 2 1 Conserved region of unknown function on GLTSCR protein UPF0565 PF10561.7 MSTRG.27155.2_1 - 1.7 7.6 4.1 3.5 6.6 4.1 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Proteasome PF00227.24 MSTRG.12758.1_1 - 4.3e-64 215.4 0.4 6e-64 214.9 0.4 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.7 MSTRG.12758.1_1 - 2.1e-14 52.7 0.5 5.4e-14 51.4 0.2 2.0 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Glyco_tranf_2_4 PF13704.4 MSTRG.295.1_1 - 8e-05 22.9 0.1 9.3e-05 22.7 0.1 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Anp1 PF03452.12 MSTRG.295.1_1 - 0.047 13.0 0.1 0.047 13.0 0.1 1.1 1 0 0 1 1 1 0 Anp1 SET PF00856.26 MSTRG.5949.1_3 - 1.6e-10 41.5 0.1 1.6e-10 41.5 0.1 2.3 3 0 0 3 3 3 1 SET domain DUF3970 PF13113.4 MSTRG.5949.1_3 - 0.13 12.4 1.6 0.25 11.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3970) Clathrin-link PF09268.8 MSTRG.5949.1_3 - 0.17 11.2 0.1 0.38 10.0 0.1 1.6 1 0 0 1 1 1 0 Clathrin, heavy-chain linker TIM21 PF08294.9 MSTRG.352.2_3 - 2.9e-48 163.3 0.0 3.9e-48 162.9 0.0 1.2 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.8 MSTRG.352.2_3 - 2.2e-05 24.1 0.0 4.4e-05 23.1 0.0 1.4 1 1 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 TFIIA PF03153.11 MSTRG.7715.2_3 - 4.1e-105 353.0 4.8 3.5e-104 350.0 4.8 1.9 1 1 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit 2Fe-2S_thioredx PF01257.17 MSTRG.21277.1_2 - 1.1e-62 210.1 0.3 1.4e-62 209.7 0.3 1.2 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin AFP PF02420.13 MSTRG.18587.1_1 - 9.5 6.8 7.8 0.89 10.0 0.2 3.2 3 0 0 3 3 3 0 Insect antifreeze protein repeat AMP-binding PF00501.26 MSTRG.16419.1_2 - 4.3e-89 298.9 0.0 5.2e-89 298.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 MSTRG.16419.1_2 - 1.2e-22 80.6 0.5 1.2e-22 80.6 0.5 2.3 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Ribosomal_S6 PF01250.15 MSTRG.7742.1_2 - 9.9e-16 57.7 0.0 1.2e-15 57.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 Pkinase PF00069.23 MSTRG.4921.1_2 - 2.6e-68 230.1 0.0 3.7e-68 229.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 MSTRG.4921.1_2 - 3.8e-38 129.3 0.0 5.6e-22 77.5 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Pkinase_Tyr PF07714.15 MSTRG.4921.1_2 - 1.8e-34 119.1 0.0 2.6e-34 118.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.4 MSTRG.4921.1_2 - 5.4e-24 84.5 0.1 4.3e-13 49.5 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.4921.1_2 - 4.6e-17 62.0 0.7 1.2e-08 35.0 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.23 MSTRG.4921.1_2 - 4.4e-15 55.5 0.2 7.1e-08 32.4 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin domain fn3 PF00041.19 MSTRG.4921.1_2 - 1.2e-11 44.7 0.1 2.3e-11 43.7 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III domain V-set PF07686.15 MSTRG.4921.1_2 - 8e-09 35.5 3.5 0.0051 16.8 0.1 4.8 3 2 0 3 3 3 2 Immunoglobulin V-set domain RIO1 PF01163.20 MSTRG.4921.1_2 - 0.00015 21.3 0.0 0.00028 20.4 0.0 1.3 1 0 0 1 1 1 1 RIO1 family C2-set_2 PF08205.10 MSTRG.4921.1_2 - 0.017 15.1 0.1 0.077 13.0 0.0 2.1 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain FTA2 PF13095.4 MSTRG.4921.1_2 - 0.054 13.0 0.3 2 7.8 0.0 2.4 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Y_Y_Y PF07495.11 MSTRG.4921.1_2 - 0.11 12.3 0.0 0.26 11.1 0.0 1.6 1 0 0 1 1 1 0 Y_Y_Y domain Toxin_16 PF07945.9 MSTRG.1029.2_2 - 1.5 8.6 7.9 0.29 10.9 1.6 2.5 2 0 0 2 2 2 0 Janus-atracotoxin PID PF00640.21 MSTRG.11283.1_3 - 1.1e-32 112.8 0.6 1.5e-32 112.4 0.6 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH3_9 PF14604.4 MSTRG.11283.1_3 - 4.7e-15 55.0 0.5 9.7e-15 54.0 0.5 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.11283.1_3 - 1.7e-07 30.6 0.0 2.7e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 SH3 domain PID_2 PF14719.4 MSTRG.11283.1_3 - 0.00037 20.3 0.2 0.00052 19.8 0.2 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 MSTRG.11283.1_3 - 0.0047 16.9 0.0 0.0074 16.3 0.0 1.3 1 0 0 1 1 1 1 Phosphotyrosine-binding domain Filament PF00038.19 MSTRG.12573.1_3 - 3.3e-91 306.0 51.6 4.3e-91 305.6 51.6 1.1 1 0 0 1 1 1 1 Intermediate filament protein LTD PF00932.17 MSTRG.12573.1_3 - 6.4e-19 68.2 0.7 3e-18 66.1 0.1 2.1 2 0 0 2 2 2 1 Lamin Tail Domain ATG16 PF08614.9 MSTRG.12573.1_3 - 0.0054 16.8 23.3 0.0054 16.8 23.3 3.4 1 1 1 3 3 3 1 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.10 MSTRG.12573.1_3 - 0.13 12.2 52.2 0.78 9.7 7.4 3.9 1 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein Laminin_II PF06009.10 MSTRG.12573.1_3 - 0.15 11.9 22.6 1.4 8.8 4.3 3.8 2 1 2 4 4 4 0 Laminin Domain II Reo_sigmaC PF04582.10 MSTRG.12573.1_3 - 0.68 9.1 11.9 1.1 8.5 1.1 3.0 1 1 1 3 3 3 0 Reovirus sigma C capsid protein Spc7 PF08317.9 MSTRG.12573.1_3 - 2.1 7.0 46.9 0.74 8.5 19.0 3.1 1 1 1 3 3 3 0 Spc7 kinetochore protein DUF4407 PF14362.4 MSTRG.12573.1_3 - 2.8 7.1 40.5 2.4 7.3 17.3 3.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.13 MSTRG.12573.1_3 - 5.1 6.4 38.2 0.092 12.2 16.9 2.5 1 1 0 2 2 2 0 Exonuclease VII, large subunit zf-ZPR1 PF03367.11 MSTRG.12573.1_3 - 8.1 6.1 7.9 7 6.4 0.6 2.9 2 0 0 2 2 2 0 ZPR1 zinc-finger domain Tht1 PF04163.10 MSTRG.12573.1_3 - 8.7 4.8 8.4 12 4.3 8.4 1.2 1 0 0 1 1 1 0 Tht1-like nuclear fusion protein Taxilin PF09728.7 MSTRG.12573.1_3 - 8.8 5.4 45.1 1e+03 -1.4 44.7 3.4 1 1 0 1 1 1 0 Myosin-like coiled-coil protein Glyco_hydro_35 PF01301.17 MSTRG.22746.1_2 - 1.7e-41 142.7 0.0 2.2e-41 142.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_35 PF01301.17 MSTRG.22746.1_3 - 0.0047 16.5 0.0 0.0064 16.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 DUF2464 PF10240.7 MSTRG.25215.3_3 - 0.026 13.9 0.0 0.04 13.3 0.0 1.3 1 0 0 1 1 1 0 Multivesicular body subunit 12 Kelch_1 PF01344.23 MSTRG.27982.3_1 - 9.9e-21 72.9 4.5 3.6e-06 26.3 0.0 5.6 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.4 MSTRG.27982.3_1 - 1.1e-20 73.3 5.5 6.3e-05 23.0 0.0 6.2 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.4 MSTRG.27982.3_1 - 3.8e-17 61.9 3.2 0.0004 20.1 0.0 5.5 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.4 MSTRG.27982.3_1 - 3.2e-16 58.8 8.6 1e-08 35.0 0.1 5.8 5 2 0 5 5 5 4 Kelch motif Kelch_5 PF13854.4 MSTRG.27982.3_1 - 1.3e-15 56.8 13.6 5.5e-06 26.1 0.1 5.1 5 0 0 5 5 5 4 Kelch motif CUB PF00431.18 MSTRG.27982.3_1 - 2.4e-14 53.5 0.0 3.8e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 CUB domain Kelch_2 PF07646.13 MSTRG.27982.3_1 - 1.3e-11 43.8 7.6 0.00025 20.7 0.1 5.5 5 1 0 5 5 5 3 Kelch motif EGF_2 PF07974.11 MSTRG.27982.3_1 - 2.3e-09 37.3 48.0 0.0015 18.7 10.0 3.6 3 0 0 3 3 3 3 EGF-like domain EGF PF00008.25 MSTRG.27982.3_1 - 0.0037 17.4 5.6 0.0037 17.4 5.6 4.3 4 0 0 4 4 4 1 EGF-like domain hEGF PF12661.5 MSTRG.27982.3_1 - 0.022 15.3 26.5 2.6 8.7 2.5 4.4 4 0 0 4 4 4 0 Human growth factor-like EGF Laminin_EGF PF00053.22 MSTRG.27982.3_1 - 0.33 11.0 39.2 0.022 14.8 10.1 3.5 2 1 1 3 3 3 0 Laminin EGF domain Adaptin_N PF01602.18 MSTRG.3034.1_1 - 2.6e-164 547.5 13.5 3.4e-164 547.1 13.5 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.5 MSTRG.3034.1_1 - 1.5e-67 226.5 8.8 1.6e-64 216.7 1.3 3.6 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.8 MSTRG.3034.1_1 - 3.1e-35 120.5 0.7 1.5e-34 118.3 0.1 2.4 1 1 1 2 2 2 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.4 MSTRG.3034.1_1 - 4e-22 78.3 2.4 3e-08 33.8 0.1 5.9 3 2 4 7 7 7 6 HEAT repeats HEAT PF02985.20 MSTRG.3034.1_1 - 1.7e-11 43.2 9.2 0.01 15.8 0.1 7.0 7 0 0 7 7 7 3 HEAT repeat Alpha_adaptinC2 PF02883.18 MSTRG.3034.1_1 - 4.3e-09 36.5 0.1 1.3e-08 35.0 0.1 1.9 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd3 PF12719.5 MSTRG.3034.1_1 - 3.4e-08 32.9 3.0 2e-05 23.8 0.3 2.6 2 0 0 2 2 2 2 Nuclear condensing complex subunits, C-term domain Arm PF00514.21 MSTRG.3034.1_1 - 2.4e-06 27.2 2.9 0.02 14.8 0.0 4.7 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.7 MSTRG.3034.1_1 - 5e-05 23.3 5.6 0.092 12.8 0.0 5.0 2 2 1 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.6 MSTRG.3034.1_1 - 0.00058 19.4 2.5 1.1 8.7 0.1 3.9 2 2 1 3 3 3 2 CLASP N terminal Arm_2 PF04826.11 MSTRG.3034.1_1 - 0.0034 16.7 0.0 0.012 15.0 0.0 1.9 1 0 0 1 1 1 1 Armadillo-like HEAT_EZ PF13513.4 MSTRG.3034.1_1 - 0.014 15.7 4.2 10 6.5 0.0 5.6 6 0 0 6 6 6 0 HEAT-like repeat Cohesin_HEAT PF12765.5 MSTRG.3034.1_1 - 0.055 13.6 0.0 40 4.4 0.0 3.7 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion UNC45-central PF11701.6 MSTRG.3034.1_1 - 0.076 12.8 0.9 2.6 7.9 0.0 3.1 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central SH2 PF00017.22 MSTRG.12523.2_2 - 2.2e-15 56.3 0.1 5.9e-15 55.0 0.1 1.8 1 0 0 1 1 1 1 SH2 domain SH2_2 PF14633.4 MSTRG.12523.2_2 - 0.03 13.6 0.4 0.092 12.0 0.0 1.9 2 0 0 2 2 2 0 SH2 domain Exo70 PF03081.13 MSTRG.10181.1_3 - 4.4e-75 253.0 5.0 4.4e-75 253.0 5.0 1.5 2 0 0 2 2 2 1 Exo70 exocyst complex subunit Sec34 PF04136.13 MSTRG.10181.1_3 - 0.012 15.4 1.5 0.054 13.3 1.5 2.2 1 0 0 1 1 1 0 Sec34-like family RolB_RolC PF02027.15 MSTRG.10181.1_3 - 0.084 12.4 0.5 0.21 11.1 0.5 1.7 1 1 0 1 1 1 0 RolB/RolC glucosidase family IZUMO PF15005.4 MSTRG.10181.1_3 - 0.25 11.8 3.8 4 7.8 0.1 3.7 4 0 0 4 4 4 0 Izumo sperm-egg fusion, Ig domain-associated LMBR1 PF04791.14 MSTRG.10181.1_3 - 3.6 6.2 5.8 1 8.1 0.7 2.3 2 1 0 2 2 2 0 LMBR1-like membrane protein Exonuc_VII_L PF02601.13 MSTRG.10181.1_3 - 3.7 6.9 5.3 0.91 8.9 0.2 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit WH1 PF00568.21 MSTRG.4337.6_2 - 1.1e-36 125.0 0.0 1.8e-36 124.3 0.0 1.3 1 0 0 1 1 1 1 WH1 domain VASP_tetra PF08776.9 MSTRG.4337.6_2 - 8.8e-18 63.5 11.3 1.4e-17 62.9 11.3 1.3 1 0 0 1 1 1 1 VASP tetramerisation domain Ran_BP1 PF00638.16 MSTRG.4337.6_2 - 0.0064 16.6 0.0 0.014 15.5 0.0 1.6 1 0 0 1 1 1 1 RanBP1 domain DUF812 PF05667.9 MSTRG.20512.1_3 - 3.8e-241 802.1 14.9 4.6e-241 801.8 14.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Reo_sigmaC PF04582.10 MSTRG.20512.1_3 - 0.22 10.8 10.2 0.39 9.9 2.3 2.4 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Occludin_ELL PF07303.11 MSTRG.20512.1_3 - 0.33 11.5 28.2 0.18 12.4 4.3 4.8 2 1 2 4 4 4 0 Occludin homology domain DUF948 PF06103.9 MSTRG.20512.1_3 - 1.3 9.2 16.4 1.1 9.4 0.5 4.3 3 2 0 3 3 3 0 Bacterial protein of unknown function (DUF948) TBPIP PF07106.11 MSTRG.20512.1_3 - 2.3 7.8 35.6 0.74 9.4 6.4 3.4 2 1 2 4 4 4 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF3573 PF12097.6 MSTRG.20512.1_3 - 4.3 5.9 11.6 0.44 9.2 2.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3573) DASH_Dad3 PF08656.8 MSTRG.20512.1_3 - 8.9 6.3 14.4 2.7 8.0 1.5 4.1 4 1 0 4 4 4 0 DASH complex subunit Dad3 zf-H2C2_2 PF13465.4 MSTRG.4066.2_3 - 1.9e-11 43.7 5.5 2.2e-06 27.7 0.2 4.7 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.4066.2_3 - 2.6e-09 36.9 35.1 2.6e-05 24.3 0.6 3.9 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.4066.2_3 - 1e-05 25.8 26.9 0.0056 17.3 2.9 3.9 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_8 PF15909.3 MSTRG.4066.2_3 - 0.055 13.6 8.3 0.74 10.0 8.3 2.5 1 1 2 3 3 3 0 C2H2-type zinc ribbon zf-C2H2_6 PF13912.4 MSTRG.4066.2_3 - 0.2 11.5 13.2 0.057 13.3 3.8 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger FOXP-CC PF16159.3 MSTRG.4066.2_3 - 0.52 10.8 11.9 2.2 8.8 1.8 3.0 3 0 0 3 3 3 0 FOXP coiled-coil domain zf-C2H2_jaz PF12171.6 MSTRG.4066.2_3 - 4.1 7.7 9.2 41 4.5 0.0 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding SCP1201-deam PF14428.4 MSTRG.24079.1_3 - 0.098 12.4 1.2 0.21 11.3 1.2 1.5 1 0 0 1 1 1 0 SCP1.201-like deaminase CS PF04969.14 MSTRG.8405.1_1 - 2.9e-13 50.5 3.2 5e-13 49.7 3.2 1.4 1 0 0 1 1 1 1 CS domain Siah-Interact_N PF09032.9 MSTRG.8405.1_1 - 1.3e-10 41.3 11.2 1.3e-10 41.3 11.2 1.9 2 0 0 2 2 2 1 Siah interacting protein, N terminal SGS PF05002.13 MSTRG.8405.1_1 - 7.7e-05 22.6 2.7 7.7e-05 22.6 2.7 1.7 2 0 0 2 2 2 1 SGS domain FlxA PF14282.4 MSTRG.8405.1_1 - 0.08 12.8 11.5 0.17 11.7 11.5 1.4 1 0 0 1 1 1 0 FlxA-like protein PRIMA1 PF16101.3 MSTRG.5452.1_2 - 4.8 7.1 8.5 15 5.5 8.5 1.8 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Homeobox_KN PF05920.9 MSTRG.5452.1_3 - 1.9e-15 56.3 0.2 4.3e-15 55.2 0.2 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 MSTRG.5452.1_3 - 1.2e-06 28.0 0.3 3.4e-06 26.6 0.3 1.7 1 0 0 1 1 1 1 Homeobox domain MRP-S32 PF10210.7 MSTRG.5452.1_3 - 0.18 12.3 0.7 0.35 11.3 0.7 1.4 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S32 TPR_2 PF07719.15 MSTRG.4719.1_3 - 7.6e-25 84.9 10.9 0.0031 17.4 0.3 8.8 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.4719.1_3 - 4.8e-23 79.9 12.3 0.00024 20.7 0.5 7.8 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.4719.1_3 - 4.5e-18 65.2 17.9 3.5e-06 27.1 0.7 6.2 5 1 2 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.4719.1_3 - 9.1e-16 56.6 11.6 0.0077 16.2 0.0 6.8 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.4719.1_3 - 4.9e-14 51.7 5.7 0.023 15.4 0.0 8.1 4 2 5 9 9 9 3 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.4719.1_3 - 2.8e-11 43.6 10.2 0.017 15.5 0.3 5.8 4 2 2 6 6 5 3 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.4719.1_3 - 6.9e-11 42.5 5.0 0.041 14.4 0.1 5.1 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.4719.1_3 - 5.8e-09 35.2 17.3 0.11 12.5 0.0 6.9 8 0 0 8 8 6 4 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.4719.1_3 - 7.3e-07 29.0 14.5 0.096 13.0 0.1 7.4 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.4719.1_3 - 2.4e-06 27.7 7.1 3.7 8.3 0.1 7.6 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.4719.1_3 - 2.6e-05 23.8 11.2 0.63 9.9 0.3 6.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_15 PF13429.4 MSTRG.4719.1_3 - 0.00021 20.5 1.7 0.00021 20.5 1.7 3.0 3 1 1 4 4 4 1 Tetratricopeptide repeat PknG_TPR PF16918.3 MSTRG.4719.1_3 - 0.013 14.1 0.1 0.024 13.2 0.1 1.4 1 0 0 1 1 1 0 Protein kinase G tetratricopeptide repeat TPR_9 PF13371.4 MSTRG.4719.1_3 - 0.016 15.2 4.0 1.5 8.9 0.0 4.2 2 2 2 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.4719.1_3 - 0.022 14.3 12.0 2.6 7.7 0.1 5.5 3 2 3 6 6 6 0 TPR repeat Coatomer_E PF04733.12 MSTRG.4719.1_3 - 0.14 11.4 4.5 1.1 8.5 0.3 3.3 1 1 2 3 3 3 0 Coatomer epsilon subunit ANAPC3 PF12895.5 MSTRG.4719.1_3 - 0.22 11.6 16.8 0.47 10.6 3.3 4.5 3 2 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 NARP1 PF12569.6 MSTRG.4719.1_3 - 0.66 8.7 7.6 0.36 9.5 0.1 2.8 2 2 1 3 3 3 0 NMDA receptor-regulated protein 1 Fis1_TPR_C PF14853.4 MSTRG.4719.1_3 - 5.5 7.0 8.0 66 3.6 0.7 3.8 4 0 0 4 4 3 0 Fis1 C-terminal tetratricopeptide repeat Collagen PF01391.16 MSTRG.29474.1_1 - 1.8e-08 33.9 24.4 2.8e-08 33.3 24.4 1.3 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) C1q PF00386.19 MSTRG.29474.1_3 - 1.2e-15 57.7 0.0 1.7e-15 57.2 0.0 1.1 1 0 0 1 1 1 1 C1q domain DUF4487 PF14868.4 MSTRG.23726.1_2 - 1e-66 225.8 6.8 1.4e-66 225.2 6.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4487) RRM PF10378.7 MSTRG.29155.1_1 - 0.026 14.1 1.1 0.037 13.6 0.1 1.7 2 0 0 2 2 2 0 Putative RRM domain zf-RING_11 PF17123.3 MSTRG.15374.4_1 - 0.013 15.1 0.0 0.027 14.0 0.0 1.5 1 0 0 1 1 1 0 RING-like zinc finger LIM PF00412.20 MSTRG.15374.4_2 - 1.3e-22 79.7 40.2 3.2e-11 43.1 11.1 3.7 4 0 0 4 4 4 3 LIM domain zf-RING_6 PF14835.4 MSTRG.15374.4_2 - 0.0034 17.1 4.5 0.0034 17.1 4.5 2.9 4 1 0 4 4 4 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.4 MSTRG.15374.4_2 - 0.0052 16.5 3.3 0.0052 16.5 3.3 3.7 3 2 0 3 3 3 1 Prokaryotic RING finger family 4 MVL PF12151.6 MSTRG.26165.2_3 - 0.018 14.7 6.2 0.13 12.0 0.5 3.5 3 0 0 3 3 3 0 Mannan-binding protein RasGEF PF00617.17 MSTRG.17878.1_2 - 4.9e-49 166.7 0.1 9.3e-49 165.8 0.1 1.5 1 0 0 1 1 1 1 RasGEF domain PDZ PF00595.22 MSTRG.17878.1_2 - 8.1e-12 45.2 0.1 2.1e-11 43.9 0.1 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) RasGEF_N PF00618.18 MSTRG.17878.1_2 - 4.9e-11 42.7 0.5 6.8e-10 39.0 0.5 2.4 1 1 0 1 1 1 1 RasGEF N-terminal motif RA PF00788.21 MSTRG.17878.1_2 - 2.8e-10 40.6 0.0 7.1e-10 39.3 0.0 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain cNMP_binding PF00027.27 MSTRG.17878.1_2 - 5.8e-05 22.9 0.0 0.0037 17.1 0.0 2.5 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain PDZ_2 PF13180.4 MSTRG.17878.1_2 - 0.00036 20.7 0.0 0.00093 19.3 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Lectin_C PF00059.19 MSTRG.9811.1_1 - 7.5e-24 84.4 2.4 1.1e-23 83.9 2.4 1.3 1 0 0 1 1 1 1 Lectin C-type domain Sushi PF00084.18 MSTRG.9811.1_1 - 0.001 19.5 0.7 0.0028 18.1 0.1 2.2 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) UL45 PF05473.10 MSTRG.9811.1_1 - 0.0014 18.2 0.0 0.0024 17.4 0.0 1.4 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Hemopexin PF00045.17 MSTRG.205.1_3 - 1.7e-22 78.9 2.3 1e-06 28.4 0.1 7.9 8 0 0 8 8 8 5 Hemopexin RMI1_N PF08585.10 MSTRG.16081.4_2 - 2.5e-26 92.7 0.4 3.6e-21 75.8 0.3 2.3 1 1 1 2 2 2 2 RecQ mediated genome instability protein UBA PF00627.29 MSTRG.16081.4_2 - 5.3e-06 26.1 1.7 9.7e-06 25.2 1.7 1.5 1 0 0 1 1 1 1 UBA/TS-N domain SMN PF06003.10 MSTRG.16081.4_3 - 6e-10 38.7 0.0 6e-10 38.7 0.0 2.4 2 1 0 2 2 2 1 Survival motor neuron protein (SMN) TUDOR PF00567.22 MSTRG.16081.4_3 - 6.9e-07 29.2 0.0 1.3e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Tudor domain DUF1325 PF07039.9 MSTRG.16081.4_3 - 0.052 13.5 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 SGF29 tudor-like domain Rib_recp_KP_reg PF05104.10 MSTRG.4684.2_3 - 1.8e-05 25.7 28.3 1.8e-05 25.7 28.3 5.8 3 1 3 6 6 6 1 Ribosome receptor lysine/proline rich region Viral_Beta_CD PF04530.10 MSTRG.4684.2_3 - 0.016 15.4 0.1 0.061 13.5 0.1 2.0 1 0 0 1 1 1 0 Viral Beta C/D like family Lip_prot_lig_C PF10437.7 MSTRG.4684.2_3 - 0.13 12.1 6.2 5.9 6.8 0.0 4.5 4 0 0 4 4 4 0 Bacterial lipoate protein ligase C-terminus PIN PF01850.19 MSTRG.4684.2_3 - 0.26 11.7 2.0 5 7.5 0.0 3.8 2 1 1 3 3 3 0 PIN domain MRVI1 PF05781.10 MSTRG.23500.4_1 - 5e-86 289.4 38.0 1e-74 252.1 24.8 3.6 2 1 1 3 3 3 2 MRVI1 protein KASH_CCD PF14662.4 MSTRG.23500.4_1 - 1.3e-66 224.0 31.4 1.3e-66 224.0 31.4 3.2 3 1 1 4 4 4 1 Coiled-coil region of CCDC155 or KASH EF-hand_9 PF14658.4 MSTRG.23500.4_1 - 2.1e-28 98.3 1.2 1.3e-27 95.7 0.2 2.5 2 0 0 2 2 2 1 EF-hand domain MPS2 PF17060.3 MSTRG.23500.4_1 - 0.0064 15.7 1.6 0.0064 15.7 1.6 3.3 3 2 1 4 4 4 1 Monopolar spindle protein 2 DUF972 PF06156.11 MSTRG.23500.4_1 - 0.0069 16.9 7.6 0.0069 16.9 7.6 5.3 4 1 1 5 5 5 3 Protein of unknown function (DUF972) EF-hand_7 PF13499.4 MSTRG.23500.4_1 - 0.015 15.7 0.2 0.056 13.8 0.2 2.1 1 0 0 1 1 1 0 EF-hand domain pair Fib_alpha PF08702.8 MSTRG.23500.4_1 - 7.4 6.6 42.5 0.024 14.7 3.9 5.3 4 1 0 5 5 5 0 Fibrinogen alpha/beta chain family BRO1 PF03097.16 MSTRG.23372.1_1 - 9.6e-33 113.4 3.0 1.2e-32 113.1 3.0 1.0 1 0 0 1 1 1 1 BRO1-like domain Dehydratase_SU PF02287.13 MSTRG.23372.1_1 - 0.04 13.9 1.1 0.092 12.7 0.5 1.8 2 0 0 2 2 2 0 Dehydratase small subunit EF-hand_1 PF00036.30 MSTRG.12551.1_1 - 1.8e-08 33.2 0.9 4.3e-08 32.0 0.9 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.4 MSTRG.12551.1_1 - 9.8e-07 29.0 0.3 1.6e-06 28.3 0.3 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.4 MSTRG.12551.1_1 - 1.2e-06 28.1 1.3 1.9e-06 27.4 1.3 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.12551.1_1 - 1.2e-06 27.8 1.4 7.1e-06 25.4 0.6 2.3 2 0 0 2 2 2 1 EF-hand domain S_100 PF01023.17 MSTRG.12551.1_1 - 5.6e-06 25.8 0.2 1.3e-05 24.7 0.2 1.6 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_5 PF13202.4 MSTRG.12551.1_1 - 6.1e-06 25.4 0.6 1.3e-05 24.4 0.6 1.6 1 0 0 1 1 1 1 EF hand EF-hand_4 PF12763.5 MSTRG.12551.1_1 - 0.0017 18.2 0.1 0.0029 17.4 0.1 1.3 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand NPIP PF06409.9 MSTRG.25600.2_3 - 0.001 18.2 6.4 0.001 18.2 6.4 2.4 2 0 0 2 2 2 1 Nuclear pore complex interacting protein (NPIP) HTH_41 PF14502.4 MSTRG.25600.2_3 - 0.0042 16.6 0.5 0.011 15.2 0.1 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain DUF4407 PF14362.4 MSTRG.25600.2_3 - 0.007 15.6 13.8 0.007 15.6 13.8 3.1 1 1 2 3 3 3 1 Domain of unknown function (DUF4407) DUF2754 PF10953.6 MSTRG.25600.2_3 - 0.17 12.0 0.4 0.41 10.8 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2754) TPR_MLP1_2 PF07926.10 MSTRG.25600.2_3 - 1.2 9.0 75.9 1.1 9.2 22.9 5.9 2 2 3 6 6 6 0 TPR/MLP1/MLP2-like protein KIP1 PF07765.10 MSTRG.25600.2_3 - 7.4 6.7 33.9 0.83 9.7 1.8 5.5 4 1 1 5 5 5 0 KIP1-like protein PH PF00169.27 MSTRG.25131.1_2 - 4.5e-17 62.3 0.5 1.2e-16 61.0 0.5 1.7 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 MSTRG.25131.1_2 - 0.00049 20.4 2.4 0.0043 17.3 2.4 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.4 MSTRG.25131.1_2 - 0.0017 18.3 0.0 0.0042 17.0 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_9 PF15410.4 MSTRG.25131.1_2 - 0.028 14.6 0.4 0.34 11.2 0.4 2.4 1 1 0 1 1 1 0 Pleckstrin homology domain PH_8 PF15409.4 MSTRG.25131.1_2 - 0.1 12.7 0.1 0.3 11.3 0.1 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain Sugar_tr PF00083.22 MSTRG.20510.1_3 - 1.1e-30 106.8 0.0 1.2e-30 106.7 0.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter PID PF00640.21 MSTRG.12533.1_2 - 1.5e-46 157.7 0.3 2.4e-46 157.1 0.3 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH2 PF00017.22 MSTRG.12533.1_2 - 1.7e-16 59.9 0.5 3.2e-16 59.0 0.0 1.8 2 0 0 2 2 2 1 SH2 domain PGM_PMM_IV PF00408.18 MSTRG.12533.1_2 - 0.087 12.9 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, C-terminal domain Ribosomal_S27e PF01667.15 MSTRG.6141.1_2 - 7.6e-30 102.3 5.1 1.2e-29 101.6 5.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S27 LCCL PF03815.17 MSTRG.17347.1_2 - 5.7e-47 157.6 10.4 1.9e-24 85.4 0.1 3.0 3 0 0 3 3 3 2 LCCL domain CAP PF00188.24 MSTRG.17347.1_2 - 7.4e-20 71.9 4.1 1.5e-19 70.9 4.1 1.6 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Rxt3 PF08642.8 MSTRG.17347.1_2 - 1.6e-06 28.8 0.0 0.45 11.1 0.0 3.3 2 1 1 3 3 3 2 Histone deacetylation protein Rxt3 DUF5133 PF17196.2 MSTRG.17347.1_2 - 0.05 13.7 0.0 0.086 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF5133) Herpes_UL3 PF03369.11 MSTRG.8682.1_1 - 0.72 10.3 3.2 1.1 9.6 3.2 1.2 1 0 0 1 1 1 0 Herpesvirus UL3 protein Ras PF00071.20 MSTRG.8682.1_2 - 6.9e-52 175.2 0.0 9.3e-52 174.7 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.8682.1_2 - 5.6e-22 78.1 0.0 9.5e-22 77.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.8682.1_2 - 4.4e-07 29.4 0.0 6.8e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 MSTRG.8682.1_2 - 0.0089 16.0 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.25 MSTRG.8682.1_2 - 0.052 13.9 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.4 MSTRG.8682.1_2 - 0.066 13.4 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain GTP_EFTU PF00009.25 MSTRG.8682.1_2 - 0.073 12.5 0.7 0.099 12.0 0.0 1.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_5 PF07728.12 MSTRG.8682.1_2 - 0.11 12.3 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) SRPRB PF09439.8 MSTRG.8682.1_2 - 0.16 11.3 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Integrase_AP2 PF14657.4 MSTRG.8682.1_3 - 0.23 11.1 4.4 0.42 10.3 4.4 1.3 1 0 0 1 1 1 0 AP2-like DNA-binding integrase domain HTH_Tnp_Tc3_2 PF01498.16 MSTRG.27862.1_1 - 0.011 15.8 0.7 0.011 15.8 0.7 1.8 2 0 0 2 2 2 0 Transposase EamA PF00892.18 MSTRG.13449.1_1 - 4.7e-05 23.4 5.5 4.7e-05 23.4 5.5 1.7 2 0 0 2 2 2 1 EamA-like transporter family UPF0060 PF02694.13 MSTRG.13449.1_1 - 0.06 13.5 1.0 0.12 12.5 1.0 1.4 1 0 0 1 1 1 0 Uncharacterised BCR, YnfA/UPF0060 family Hum_adeno_E3A PF05393.9 MSTRG.13449.1_1 - 0.15 11.9 5.4 0.086 12.7 0.6 2.2 1 1 1 2 2 2 0 Human adenovirus early E3A glycoprotein DUF747 PF05346.9 MSTRG.17867.2_2 - 8.2e-46 156.8 7.4 1.3e-45 156.1 7.4 1.3 1 0 0 1 1 1 1 Eukaryotic membrane protein family Myb_DNA-binding PF00249.29 MSTRG.16817.1_3 - 1.9e-17 63.0 6.8 8.6e-07 28.9 0.0 5.3 6 0 0 6 6 6 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 MSTRG.16817.1_3 - 4.1e-10 39.6 7.7 2e-07 31.0 0.3 4.0 2 1 1 3 3 3 2 Myb-like DNA-binding domain B12D PF06522.9 MSTRG.17425.1_2 - 6.8e-23 80.1 0.1 1.6e-22 79.0 0.0 1.6 2 0 0 2 2 2 1 NADH-ubiquinone reductase complex 1 MLRQ subunit IMD PF08397.9 MSTRG.12976.2_3 - 1.9e-89 298.6 3.4 1.9e-89 298.6 3.4 1.7 2 0 0 2 2 2 1 IRSp53/MIM homology domain TFIIA PF03153.11 MSTRG.12976.2_3 - 0.37 10.6 22.8 0.008 16.1 16.0 1.7 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Exonuc_VII_L PF02601.13 MSTRG.12976.2_3 - 1.4 8.3 9.4 6.1 6.2 3.7 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit Peptidase_M20 PF01546.26 MSTRG.3455.1_1 - 1.8e-35 122.4 0.0 2.6e-35 121.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.12 MSTRG.3455.1_1 - 2.8e-14 52.8 0.0 4.4e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain WG_beta_rep PF14903.4 MSTRG.3455.1_1 - 0.0096 16.1 0.0 0.077 13.2 0.0 2.3 2 0 0 2 2 2 1 WG containing repeat 7tm_2 PF00002.22 MSTRG.9447.1_2 - 1.1e-16 60.8 1.4 2e-16 59.9 1.4 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) ACBP PF00887.17 MSTRG.21132.1_2 - 1.2e-24 86.2 0.0 2.3e-24 85.3 0.0 1.5 1 0 0 1 1 1 1 Acyl CoA binding protein Dynactin_p22 PF07426.9 MSTRG.21132.1_2 - 0.067 12.9 1.1 0.47 10.2 0.1 2.2 2 0 0 2 2 2 0 Dynactin subunit p22 DAGK_acc PF00609.17 MSTRG.14158.1_1 - 3.7e-53 180.0 0.0 4.8e-53 179.6 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.22 MSTRG.14158.1_1 - 1.4e-06 27.8 0.0 2.8e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain L27 PF02828.14 MSTRG.1152.1_1 - 0.021 14.4 0.3 3.1 7.5 0.4 2.7 2 0 0 2 2 2 0 L27 domain L27 PF02828.14 MSTRG.1152.1_3 - 0.081 12.6 1.6 0.11 12.2 0.1 1.8 2 0 0 2 2 2 0 L27 domain SR-25 PF10500.7 MSTRG.17117.1_2 - 6.6e-08 32.3 30.7 6.6e-08 32.3 30.7 3.9 2 1 1 3 3 3 2 Nuclear RNA-splicing-associated protein TFIIF_alpha PF05793.10 MSTRG.17117.1_2 - 0.0011 17.5 89.3 0.034 12.6 53.5 2.2 2 0 0 2 2 2 2 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) MIP-T3 PF10243.7 MSTRG.17117.1_2 - 0.3 9.6 78.5 0.093 11.3 50.3 2.1 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 DUF1777 PF08648.10 MSTRG.17117.1_2 - 2 8.5 59.6 1.5 9.0 13.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1777) DUF4700 PF15771.3 MSTRG.17117.1_3 - 5.4 5.5 16.4 7.7 5.0 16.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4700) DUF3149 PF11346.6 MSTRG.7670.1_2 - 2.2 7.9 4.9 7.9 6.1 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3149) DUF3915 PF13054.4 MSTRG.13297.1_1 - 0.0023 17.8 9.3 0.0042 16.9 9.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 MSTRG.13297.1_1 - 0.0025 16.0 14.1 0.0038 15.5 14.1 1.1 1 0 0 1 1 1 1 Atrophin-1 family PRP38_assoc PF12871.5 MSTRG.13297.1_1 - 2.6 8.5 19.1 6.1 7.3 19.1 1.6 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term FAM27 PF15832.3 MSTRG.13297.1_1 - 5.3 7.5 18.3 1.5 9.3 14.3 2.2 2 0 0 2 2 2 0 FAM27 D and E protein family PAS_3 PF08447.10 MSTRG.13297.1_2 - 2.3e-20 72.5 0.0 7e-14 51.7 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 MSTRG.13297.1_2 - 1e-13 51.2 0.0 7.5e-11 42.0 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS PF00989.23 MSTRG.13297.1_2 - 1.6e-10 40.8 0.0 9.1e-10 38.4 0.0 2.2 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.5 MSTRG.13297.1_2 - 0.00012 22.2 0.0 0.0096 16.0 0.0 2.6 2 0 0 2 2 2 1 PAS domain FAM27 PF15832.3 MSTRG.13297.1_2 - 0.0027 18.1 13.1 0.0067 16.8 13.1 1.6 1 0 0 1 1 1 1 FAM27 D and E protein family HLH PF00010.24 MSTRG.13297.1_2 - 0.0053 16.6 0.0 0.0053 16.6 0.0 2.5 2 1 0 2 2 2 1 Helix-loop-helix DNA-binding domain DUF3915 PF13054.4 MSTRG.13297.1_2 - 0.13 12.1 13.6 0.019 14.8 7.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) DUF3915 PF13054.4 MSTRG.13297.1_3 - 0.016 15.0 7.9 0.027 14.3 7.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 MSTRG.13297.1_3 - 0.021 13.0 16.9 0.034 12.3 16.9 1.3 1 0 0 1 1 1 0 Atrophin-1 family AA_permease PF00324.19 MSTRG.12655.2_1 - 1.3e-66 225.1 64.5 2.3e-63 214.3 51.1 2.5 2 1 1 3 3 3 2 Amino acid permease SLC12 PF03522.13 MSTRG.12655.2_1 - 4.7e-15 55.4 0.1 5.4e-10 38.7 0.0 3.5 3 1 0 3 3 3 2 Solute carrier family 12 AA_permease_2 PF13520.4 MSTRG.12655.2_1 - 2.6e-12 46.1 53.3 2.6e-12 46.1 53.3 1.7 2 0 0 2 2 2 1 Amino acid permease TraC_F_IV PF11130.6 MSTRG.12655.2_1 - 0.047 13.1 0.0 0.088 12.3 0.0 1.4 1 0 0 1 1 1 0 F pilus assembly Type-IV secretion system for plasmid transfer Endothelin PF00322.15 MSTRG.12655.2_2 - 0.32 10.5 7.7 0.18 11.3 1.3 3.6 3 0 0 3 3 3 0 Endothelin family EF-hand_7 PF13499.4 MSTRG.10779.2_3 - 2.3e-14 53.5 0.1 6.8e-06 26.3 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 MSTRG.10779.2_3 - 2.5e-14 51.5 0.0 0.00013 21.1 0.0 3.7 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.4 MSTRG.10779.2_3 - 1.5e-13 49.4 0.0 3.6e-05 23.2 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.4 MSTRG.10779.2_3 - 4.9e-10 38.3 0.1 0.00031 20.0 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.4 MSTRG.10779.2_3 - 1.2e-05 24.9 0.4 0.28 10.8 0.4 3.4 2 1 1 3 3 3 3 EF-hand domain pair PDZ PF00595.22 MSTRG.13130.1_2 - 3e-11 43.4 0.0 3.8e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.13130.1_2 - 6.5e-07 29.4 0.0 1.1e-06 28.7 0.0 1.4 1 1 0 1 1 1 1 PDZ domain EGF PF00008.25 MSTRG.17966.1_2 - 9.9e-13 48.0 47.9 5.9e-09 35.9 1.8 4.6 4 0 0 4 4 4 2 EGF-like domain hEGF PF12661.5 MSTRG.17966.1_2 - 3e-07 30.7 17.1 1.2e-05 25.6 3.4 5.2 5 0 0 5 5 5 2 Human growth factor-like EGF EGF_2 PF07974.11 MSTRG.17966.1_2 - 0.00011 22.3 58.5 0.17 12.1 14.0 4.5 4 1 0 4 4 4 3 EGF-like domain Laminin_EGF PF00053.22 MSTRG.17966.1_2 - 0.00073 19.5 46.0 0.031 14.3 6.5 4.3 1 1 3 4 4 4 3 Laminin EGF domain EGF_3 PF12947.5 MSTRG.17966.1_2 - 0.018 15.1 11.4 0.018 15.1 11.4 4.3 3 1 1 4 4 4 0 EGF domain EGF_CA PF07645.13 MSTRG.17966.1_2 - 0.53 10.4 46.9 0.11 12.6 13.4 4.6 2 2 1 3 3 3 0 Calcium-binding EGF domain Methyltr_RsmB-F PF01189.15 MSTRG.10356.1_2 - 0.00016 21.2 0.0 0.00025 20.6 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F DFF-C PF09033.8 MSTRG.18248.1_1 - 9.2e-40 136.1 1.1 9.2e-40 136.1 1.1 1.5 2 0 0 2 2 2 1 DNA Fragmentation factor 45kDa, C terminal domain HR1 PF02185.14 MSTRG.18248.1_1 - 0.056 13.4 1.0 0.056 13.4 1.0 2.3 2 0 0 2 2 2 0 Hr1 repeat FAST_1 PF06743.13 MSTRG.18248.1_1 - 0.08 12.7 0.1 0.53 10.1 0.1 2.0 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 Beta_helix PF13229.4 MSTRG.4866.1_1 - 2.1e-96 320.0 96.4 5.3e-27 94.5 13.0 5.1 1 1 6 7 7 7 5 Right handed beta helix region NosD PF05048.11 MSTRG.4866.1_1 - 5.8e-40 136.9 33.6 7e-17 61.4 10.5 3.7 1 1 3 4 4 4 4 Periplasmic copper-binding protein (NosD) F-box-like PF12937.5 MSTRG.4866.1_1 - 7e-16 57.7 0.4 1.9e-15 56.4 0.4 1.7 1 0 0 1 1 1 1 F-box-like zf-UBR PF02207.18 MSTRG.4866.1_1 - 5.2e-09 36.0 13.1 5.2e-09 36.0 13.1 2.1 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) F-box PF00646.31 MSTRG.4866.1_1 - 1.4e-08 34.2 0.2 3.4e-08 33.0 0.2 1.6 1 0 0 1 1 1 1 F-box domain C2 PF00168.28 MSTRG.23113.1_1 - 4.9e-05 23.4 0.0 7e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 C2 domain Trypsin PF00089.24 MSTRG.17185.3_3 - 5.5e-81 271.4 3.0 6.4e-81 271.2 3.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 MSTRG.17185.3_3 - 0.002 18.9 0.1 0.0031 18.3 0.1 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 MSTRG.17185.3_3 - 0.069 13.4 1.6 0.09 13.0 0.1 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF1986) CDC50 PF03381.13 MSTRG.18373.1_2 - 6.7e-48 163.4 0.1 9.7e-48 162.9 0.1 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family CDC50 PF03381.13 MSTRG.18373.1_3 - 1.5e-17 63.9 0.2 2.2e-17 63.4 0.2 1.2 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Sec23_helical PF04815.13 MSTRG.933.2_1 - 0.013 15.1 0.0 0.028 14.1 0.0 1.6 2 0 0 2 2 2 0 Sec23/Sec24 helical domain Gelsolin PF00626.20 MSTRG.933.2_2 - 5.6e-12 45.3 0.0 7.7e-12 44.8 0.0 1.2 1 0 0 1 1 1 1 Gelsolin repeat RPEL PF02755.13 MSTRG.458.2_2 - 1.5e-22 78.4 8.2 6.3e-07 28.8 0.1 3.6 3 0 0 3 3 3 3 RPEL repeat SAP PF02037.25 MSTRG.458.2_2 - 8.8e-12 44.4 0.4 1.7e-11 43.4 0.4 1.5 1 0 0 1 1 1 1 SAP domain PKcGMP_CC PF16808.3 MSTRG.458.2_2 - 0.065 13.0 6.5 0.17 11.7 6.5 1.7 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ABC1 PF03109.14 MSTRG.27168.1_1 - 5.7e-31 107.0 0.0 1e-30 106.2 0.0 1.4 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.20 MSTRG.27168.1_1 - 0.15 11.5 0.0 0.39 10.2 0.0 1.6 2 0 0 2 2 2 0 RIO1 family ubiquitin PF00240.21 MSTRG.22787.4_1 - 1.1e-23 82.6 3.1 5.9e-13 48.2 0.1 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.6 MSTRG.22787.4_1 - 1.9e-09 37.1 0.5 5.2e-05 22.9 0.0 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.4 MSTRG.22787.4_1 - 0.014 15.4 0.1 0.14 12.1 0.0 2.0 1 1 1 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Piwi PF02171.15 MSTRG.6802.1_1 - 3.1e-109 364.7 0.1 4.1e-109 364.3 0.1 1.1 1 0 0 1 1 1 1 Piwi domain ArgoMid PF16487.3 MSTRG.6802.1_3 - 9.6e-32 109.0 0.1 2.9e-31 107.4 0.0 1.8 2 0 0 2 2 2 1 Mid domain of argonaute PAZ PF02170.20 MSTRG.6802.1_3 - 5.5e-29 100.6 2.3 7.7e-29 100.1 2.3 1.2 1 0 0 1 1 1 1 PAZ domain ArgoL2 PF16488.3 MSTRG.6802.1_3 - 2.5e-13 50.0 0.0 4.4e-13 49.2 0.0 1.4 1 0 0 1 1 1 1 Argonaute linker 2 domain zf-C3HC4_2 PF13923.4 MSTRG.23520.3_2 - 3.7e-05 23.3 11.1 3.7e-05 23.3 11.1 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.23520.3_2 - 5.8e-05 22.9 13.7 0.00024 20.9 13.7 2.2 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 MSTRG.23520.3_2 - 9e-05 22.1 11.4 9e-05 22.1 11.4 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 MSTRG.23520.3_2 - 0.00036 20.2 7.6 0.00036 20.2 7.6 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.23520.3_2 - 0.0025 17.9 12.4 0.0025 17.9 12.4 2.7 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.4 MSTRG.23520.3_2 - 0.0027 17.7 12.0 0.0027 17.7 12.0 2.9 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.4 MSTRG.23520.3_2 - 0.0031 17.2 3.3 0.0084 15.8 3.3 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.4 MSTRG.23520.3_2 - 0.011 15.5 10.2 0.011 15.5 10.2 3.4 4 0 0 4 4 4 0 zinc-RING finger domain zf-C3HC4_5 PF17121.3 MSTRG.23520.3_2 - 0.15 11.9 5.0 0.45 10.3 5.0 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 MSTRG.23520.3_2 - 0.34 10.7 16.7 0.47 10.2 11.9 3.4 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 UPF0220 PF05255.9 MSTRG.1174.1_3 - 1.3e-47 161.3 2.3 2.1e-47 160.6 2.3 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) Bacteriocin_II PF01721.16 MSTRG.1174.1_3 - 0.026 14.5 1.1 0.055 13.4 1.1 1.5 1 0 0 1 1 1 0 Class II bacteriocin Pep_M12B_propep PF01562.17 MSTRG.17618.1_2 - 8.5e-34 116.7 0.0 1.1e-33 116.3 0.0 1.2 1 0 0 1 1 1 1 Reprolysin family propeptide zf-C2H2 PF00096.24 MSTRG.17618.1_3 - 0.14 12.6 1.3 0.59 10.6 1.3 2.1 1 0 0 1 1 1 0 Zinc finger, C2H2 type Myb_DNA-binding PF00249.29 MSTRG.23395.1_2 - 3.2e-53 177.5 19.3 2.8e-18 65.6 2.3 3.5 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 MSTRG.23395.1_2 - 3e-40 136.1 16.7 2.1e-17 63.0 1.1 3.4 1 1 2 3 3 3 3 Myb-like DNA-binding domain LMSTEN PF07988.10 MSTRG.23395.1_2 - 3.8e-23 80.5 0.2 7.4e-23 79.6 0.2 1.5 1 0 0 1 1 1 1 LMSTEN motif Cmyb_C PF09316.8 MSTRG.23395.1_2 - 9.3e-19 67.6 0.3 1.7e-18 66.7 0.3 1.4 1 0 0 1 1 1 1 C-myb, C-terminal Myb_DNA-bind_7 PF15963.3 MSTRG.23395.1_2 - 5.2e-08 32.5 4.2 0.0039 16.9 0.1 3.4 1 1 2 3 3 3 2 Myb DNA-binding like SLIDE PF09111.8 MSTRG.23395.1_2 - 9.6e-07 28.7 1.0 0.72 9.8 0.0 3.5 1 1 2 3 3 3 3 SLIDE SANT_DAMP1_like PF16282.3 MSTRG.23395.1_2 - 0.001 19.1 4.8 0.3 11.2 0.0 3.3 1 1 1 3 3 3 1 SANT/Myb-like domain of DAMP1 Rap1_C PF11626.6 MSTRG.23395.1_2 - 0.0083 16.1 7.1 3.2 7.8 0.8 3.4 1 1 2 3 3 3 2 TRF2-interacting telomeric protein/Rap1 - C terminal domain Spore_III_AB PF09548.8 MSTRG.23395.1_2 - 0.17 11.9 0.2 0.68 9.9 0.1 1.9 1 1 1 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) NADH_B2 PF14813.4 MSTRG.15212.1_3 - 2.2e-34 116.9 3.7 3.4e-34 116.3 3.7 1.3 1 0 0 1 1 1 1 NADH dehydrogenase 1 beta subcomplex subunit 2 B56 PF01603.18 MSTRG.26273.1_1 - 1.1e-128 429.6 8.4 4.2e-91 305.8 0.2 2.1 2 0 0 2 2 2 2 Protein phosphatase 2A regulatory B subunit (B56 family) Ank_2 PF12796.5 MSTRG.16222.2_2 - 2.4e-21 76.0 0.1 3.7e-11 43.3 0.4 2.6 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.16222.2_2 - 2.7e-16 59.3 3.3 3.9e-10 39.7 0.5 4.3 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.4 MSTRG.16222.2_2 - 5.8e-16 58.5 0.9 7.8e-07 29.4 0.0 4.1 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.16222.2_2 - 2.3e-14 53.0 0.2 0.0047 17.2 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.4 MSTRG.16222.2_2 - 7.1e-12 44.3 0.2 0.058 13.8 0.0 4.8 4 0 0 4 4 4 4 Ankyrin repeat Ribosomal_L36e PF01158.16 MSTRG.8475.1_1 - 1.3e-49 166.2 7.3 1.6e-49 166.0 7.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L36e DUF3458 PF11940.6 MSTRG.4919.1_2 - 0.025 13.5 0.2 0.035 13.0 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3458) zf-DHHC PF01529.18 MSTRG.4919.1_3 - 6.4e-35 120.0 7.3 6.4e-35 120.0 7.3 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase SH3_2 PF07653.15 MSTRG.4919.1_3 - 1.9e-07 30.5 0.0 5e-07 29.2 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain FMO-like PF00743.17 MSTRG.23782.1_3 - 5.9e-107 358.1 0.0 7.3e-107 357.8 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.4 MSTRG.23782.1_3 - 0.0028 16.8 0.0 0.0043 16.2 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase adh_short PF00106.23 MSTRG.7118.1_2 - 6.6e-34 116.9 0.2 3e-33 114.8 0.2 1.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 MSTRG.7118.1_2 - 1.6e-20 73.6 0.1 5.9e-20 71.7 0.1 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 MSTRG.7118.1_2 - 3.6e-09 36.6 0.1 6.2e-09 35.9 0.1 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.19 MSTRG.7118.1_2 - 0.0043 16.4 0.1 0.0087 15.4 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.18 MSTRG.7118.1_2 - 0.017 15.0 0.1 0.033 14.1 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.17 MSTRG.7118.1_2 - 0.038 13.2 0.0 0.097 11.9 0.0 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_10 PF13460.4 MSTRG.7118.1_2 - 0.044 13.6 0.2 0.1 12.4 0.2 1.6 1 0 0 1 1 1 0 NAD(P)H-binding GDP_Man_Dehyd PF16363.3 MSTRG.7118.1_2 - 0.15 11.3 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase HORMA PF02301.16 MSTRG.3583.1_1 - 1.6e-55 187.9 0.3 4e-55 186.6 0.0 1.7 2 0 0 2 2 2 1 HORMA domain DRY_EERY PF09750.7 MSTRG.3583.1_3 - 0.49 10.5 3.5 0.76 9.9 3.5 1.2 1 0 0 1 1 1 0 Alternative splicing regulator Trypsin PF00089.24 MSTRG.20101.1_2 - 8.1e-56 189.2 0.1 1.1e-55 188.7 0.1 1.2 1 0 0 1 1 1 1 Trypsin Gla PF00594.18 MSTRG.20101.1_2 - 5.3e-20 71.2 7.8 9.2e-20 70.4 7.8 1.4 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FXa_inhibition PF14670.4 MSTRG.20101.1_2 - 4.6e-09 36.3 19.8 1.6e-07 31.4 9.8 3.1 1 1 1 2 2 2 2 Coagulation Factor Xa inhibitory site EGF PF00008.25 MSTRG.20101.1_2 - 1e-08 35.2 5.7 1e-08 35.2 5.7 3.1 2 0 0 2 2 2 1 EGF-like domain DUF1986 PF09342.9 MSTRG.20101.1_2 - 1.4e-07 31.7 0.0 3.8e-07 30.4 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) cEGF PF12662.5 MSTRG.20101.1_2 - 7.3e-06 25.7 6.9 0.00081 19.1 0.4 3.0 2 0 0 2 2 2 2 Complement Clr-like EGF-like hEGF PF12661.5 MSTRG.20101.1_2 - 0.00062 20.2 5.2 0.00062 20.2 5.2 4.5 3 1 0 3 3 3 1 Human growth factor-like EGF Trypsin_2 PF13365.4 MSTRG.20101.1_2 - 0.0011 19.7 0.0 0.0019 18.9 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain EGF_2 PF07974.11 MSTRG.20101.1_2 - 0.0077 16.4 9.5 0.0077 16.4 9.5 4.0 5 0 0 5 5 5 1 EGF-like domain Plasmod_Pvs28 PF06247.9 MSTRG.20101.1_2 - 0.87 9.8 12.9 1.1 9.5 4.4 2.6 2 0 0 2 2 2 0 Pvs28 EGF domain DIX PF00778.15 MSTRG.19185.1_3 - 1.4e-27 95.2 0.1 2.9e-27 94.2 0.1 1.5 1 0 0 1 1 1 1 DIX domain Herpes_US9 PF06072.9 MSTRG.13601.1_1 - 0.47 10.2 3.6 0.18 11.6 0.3 2.0 2 0 0 2 2 2 0 Alphaherpesvirus tegument protein US9 DUF4079 PF13301.4 MSTRG.13601.1_1 - 0.84 9.6 4.8 2.5 8.1 4.8 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) Lipocalin PF00061.21 MSTRG.19689.4_1 - 1.2e-20 74.1 1.5 1.4e-20 73.8 1.5 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 MSTRG.19689.4_1 - 1.4e-05 24.9 1.3 1.7e-05 24.6 1.3 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Glyco_transf_8 PF01501.18 MSTRG.13055.1_3 - 5.2e-08 32.6 0.0 9.5e-08 31.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 ThiF PF00899.19 MSTRG.11372.2_3 - 3.5e-89 298.2 0.0 4.7e-61 206.1 0.0 2.4 2 1 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.7 MSTRG.11372.2_3 - 2e-76 257.1 0.4 2.9e-76 256.6 0.4 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.3 MSTRG.11372.2_3 - 4.7e-25 87.5 0.0 8.5e-25 86.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.3 MSTRG.11372.2_3 - 1.5e-17 63.4 0.2 4.5e-17 61.8 0.2 1.9 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle E1_UFD PF09358.8 MSTRG.11372.2_3 - 1.5e-12 47.9 0.0 1.9e-11 44.4 0.0 2.5 2 0 0 2 2 2 1 Ubiquitin fold domain WD40 PF00400.30 MSTRG.12224.2_1 - 1.9e-05 25.2 0.0 3.4e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 WD domain, G-beta repeat Ndr PF03096.12 MSTRG.13112.2_3 - 3.8e-119 396.4 0.0 4.8e-119 396.1 0.0 1.1 1 0 0 1 1 1 1 Ndr family Abhydrolase_1 PF00561.18 MSTRG.13112.2_3 - 0.0011 18.6 0.0 0.032 13.7 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 MSTRG.13112.2_3 - 0.0023 18.5 0.0 0.0045 17.5 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lectin_N PF03954.12 MSTRG.21949.1_1 - 0.16 11.6 0.6 0.37 10.4 0.6 1.6 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain stn_TNFRSF12A PF12191.6 MSTRG.21949.1_3 - 4.8e-06 26.7 0.1 1.4e-05 25.2 0.1 1.7 1 0 0 1 1 1 1 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain DUF3736 PF12540.6 MSTRG.23161.1_2 - 5.5e-45 152.7 17.1 7.3e-40 136.1 10.2 4.8 3 1 0 3 3 3 2 Protein of unknown function (DUF3736) MIP-T3 PF10243.7 MSTRG.23161.1_2 - 1.8e-05 23.5 30.5 1.8e-05 23.5 30.5 2.7 2 1 0 2 2 2 1 Microtubule-binding protein MIP-T3 DUF321 PF03778.11 MSTRG.18181.1_2 - 0.44 10.1 2.2 19 4.9 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF321) RCC1 PF00415.16 MSTRG.17214.3_1 - 2.8e-79 261.4 14.0 1.8e-11 44.3 0.0 7.3 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 MSTRG.17214.3_1 - 3.1e-26 90.5 28.2 3.8e-09 36.0 0.4 8.0 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat Peptidase_C25_C PF03785.12 MSTRG.17214.3_1 - 2.1e-05 24.1 0.1 0.034 13.9 0.1 3.4 3 0 0 3 3 3 1 Peptidase family C25, C terminal ig-like domain PapC_C PF13953.4 MSTRG.17214.3_1 - 0.27 11.0 1.2 0.91 9.3 0.2 2.4 2 0 0 2 2 2 0 PapC C-terminal domain PRY PF13765.4 MSTRG.4900.3_2 - 3e-12 45.8 0.4 1.1e-11 44.0 0.0 2.2 3 0 0 3 3 3 1 SPRY-associated domain zf-C3HC4_2 PF13923.4 MSTRG.4900.3_2 - 2.6e-08 33.4 8.0 6.8e-08 32.1 8.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 MSTRG.4900.3_2 - 3.4e-08 33.1 6.5 9.5e-08 31.7 6.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 MSTRG.4900.3_2 - 4.8e-07 29.7 5.7 4.8e-07 29.7 5.7 2.6 3 0 0 3 3 2 1 B-box zinc finger zf-C3HC4_3 PF13920.4 MSTRG.4900.3_2 - 2.7e-06 27.0 5.0 2.7e-06 27.0 5.0 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 MSTRG.4900.3_2 - 4e-06 26.7 8.5 4e-06 26.7 8.5 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.4 MSTRG.4900.3_2 - 5.7e-06 26.4 9.6 5.7e-06 26.4 9.6 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.4 MSTRG.4900.3_2 - 8.3e-06 25.6 4.0 2.4e-05 24.1 4.0 1.9 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.4 MSTRG.4900.3_2 - 8.3e-05 22.2 7.0 8.3e-05 22.2 7.0 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 MSTRG.4900.3_2 - 0.00041 20.1 5.0 0.00041 20.1 5.0 2.0 2 0 0 2 2 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.3 MSTRG.4900.3_2 - 0.0015 18.0 7.9 0.0037 16.7 7.9 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.5 MSTRG.4900.3_2 - 0.011 15.9 8.9 0.011 15.9 8.9 2.6 2 0 0 2 2 2 0 RING-H2 zinc finger domain SPRY PF00622.26 MSTRG.4900.3_2 - 0.06 13.3 0.0 0.19 11.8 0.0 1.9 1 0 0 1 1 1 0 SPRY domain Spc7 PF08317.9 MSTRG.4900.3_2 - 0.37 9.5 8.5 0.55 8.9 8.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein IncA PF04156.12 MSTRG.4900.3_2 - 0.4 10.3 5.1 0.76 9.4 5.1 1.5 1 0 0 1 1 1 0 IncA protein APG6 PF04111.10 MSTRG.4900.3_2 - 0.45 9.7 7.4 0.66 9.2 7.4 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 AAA_23 PF13476.4 MSTRG.4900.3_2 - 0.72 10.2 5.4 1.1 9.6 5.4 1.2 1 0 0 1 1 1 0 AAA domain zf-ANAPC11 PF12861.5 MSTRG.4900.3_2 - 1.2 9.1 10.4 0.19 11.7 5.8 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger SPAR_C PF11881.6 MSTRG.7822.1_3 - 1.7e-30 106.5 8.9 5.3e-25 88.6 0.9 2.5 2 1 1 3 3 3 2 C-terminal domain of SPAR protein IncA PF04156.12 MSTRG.7822.1_3 - 0.0045 16.7 5.1 0.0045 16.7 5.1 2.1 2 0 0 2 2 2 1 IncA protein RasGAP_C PF03836.13 MSTRG.7822.1_3 - 0.044 13.8 2.1 0.1 12.7 2.1 1.5 1 0 0 1 1 1 0 RasGAP C-terminus DUF972 PF06156.11 MSTRG.7822.1_3 - 0.12 12.9 1.8 0.32 11.5 1.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF972) CASP_C PF08172.10 MSTRG.7822.1_3 - 0.21 10.8 4.1 0.41 9.8 4.1 1.4 1 0 0 1 1 1 0 CASP C terminal bZIP_2 PF07716.13 MSTRG.7822.1_3 - 1.5 8.8 9.5 0.44 10.5 5.9 2.0 2 0 0 2 2 2 0 Basic region leucine zipper DUF2968 PF11180.6 MSTRG.7822.1_3 - 9.6 5.7 14.3 0.09 12.3 5.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) CTF_NFI PF00859.16 MSTRG.27879.3_3 - 1.5e-111 373.0 23.0 2.2e-111 372.4 18.1 2.6 2 1 0 2 2 2 1 CTF/NF-I family transcription modulation region NfI_DNAbd_pre-N PF10524.7 MSTRG.27879.3_3 - 7.8e-27 92.8 2.9 1.6e-26 91.8 2.9 1.5 1 0 0 1 1 1 1 Nuclear factor I protein pre-N-terminus Tma16 PF11176.6 MSTRG.27541.1_3 - 3.8e-43 146.7 1.9 6.5e-43 146.0 1.9 1.4 1 0 0 1 1 1 1 Translation machinery-associated protein 16 FAM176 PF14851.4 MSTRG.27541.1_3 - 0.95 9.0 5.7 1.5 8.3 3.6 2.0 2 0 0 2 2 2 0 FAM176 family CRF PF00473.15 MSTRG.22604.3_2 - 5.3e-14 51.9 3.5 5.3e-14 51.9 3.5 2.1 2 0 0 2 2 2 1 Corticotropin-releasing factor family Ricin_B_lectin PF00652.20 MSTRG.1131.1_2 - 5.2e-30 104.2 0.9 9.7e-30 103.3 0.9 1.5 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.12 MSTRG.1131.1_2 - 4e-06 26.3 0.1 8.7e-06 25.2 0.1 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase RicinB_lectin_2 PF14200.4 MSTRG.1131.1_2 - 0.00067 20.2 0.0 0.35 11.5 0.0 2.7 2 0 0 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Pkinase PF00069.23 MSTRG.20940.2_1 - 2.4e-70 236.8 0.0 3e-70 236.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.20940.2_1 - 7e-33 113.9 0.1 9.6e-33 113.4 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.20940.2_1 - 0.0006 19.1 0.2 0.16 11.1 0.0 2.2 2 0 0 2 2 2 2 Kinase-like RIO1 PF01163.20 MSTRG.20940.2_1 - 0.23 10.9 1.0 0.68 9.4 1.0 1.7 1 1 0 1 1 1 0 RIO1 family Peptidase_C48 PF02902.17 MSTRG.12102.1_1 - 1.5e-36 126.2 1.7 2.2e-36 125.6 1.7 1.2 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain zf-CCHC_2 PF13696.4 MSTRG.1302.2_2 - 0.091 12.4 4.8 0.044 13.5 1.6 2.2 2 0 0 2 2 2 0 Zinc knuckle T-box PF00907.20 MSTRG.1302.2_3 - 5.1e-69 232.0 1.0 1.1e-68 230.9 1.0 1.6 1 0 0 1 1 1 1 T-box DUF4801 PF16059.3 MSTRG.1302.2_3 - 9.4e-12 44.6 9.3 2.2e-11 43.4 9.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4801) Glyco_transf_8 PF01501.18 MSTRG.8999.1_1 - 7.2e-16 58.4 0.0 4.6e-14 52.5 0.0 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.6 MSTRG.8999.1_1 - 0.002 17.4 0.0 0.0032 16.7 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Myosin_head PF00063.19 MSTRG.19615.4_2 - 1.9e-67 227.9 0.0 3.7e-67 226.9 0.0 1.5 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 MSTRG.19615.4_2 - 1e-18 66.5 128.7 7.5e-15 53.7 74.0 2.2 1 1 0 2 2 2 2 Myosin tail AAA_22 PF13401.4 MSTRG.19615.4_2 - 0.012 15.7 0.0 0.012 15.7 0.0 3.4 3 0 0 3 3 3 0 AAA domain ATPase PF06745.11 MSTRG.19615.4_2 - 0.24 10.6 0.0 0.24 10.6 0.0 2.9 3 0 0 3 3 3 0 KaiC COMMD1_N PF17221.1 MSTRG.19615.4_2 - 1.9 8.7 9.8 0.11 12.7 1.6 3.3 3 0 0 3 3 3 0 COMMD1 N-terminal domain Tmemb_161AB PF10268.7 MSTRG.23589.1_1 - 1.6e-190 633.6 6.3 2.2e-190 633.2 6.3 1.1 1 0 0 1 1 1 1 Predicted transmembrane protein 161AB GPR_Gpa2_C PF11970.6 MSTRG.23589.1_1 - 0.17 11.9 1.9 18 5.3 0.3 2.7 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 C-term HTH_23 PF13384.4 MSTRG.23589.1_2 - 0.024 14.3 0.0 0.053 13.2 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain DUF4481 PF14800.4 MSTRG.7923.2_1 - 2e-22 79.9 0.6 2.6e-22 79.5 0.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4481) DUF4481 PF14800.4 MSTRG.7923.2_2 - 8.5e-75 251.8 5.6 1.2e-74 251.4 5.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4481) TMEM70 PF06979.10 MSTRG.15681.1_2 - 1.9e-54 183.5 0.3 3.4e-54 182.6 0.3 1.4 1 0 0 1 1 1 1 Assembly, mitochondrial proton-transport ATP synth complex RHD_DNA_bind PF00554.20 MSTRG.25981.2_2 - 6.1e-66 221.4 0.2 1.6e-65 220.0 0.1 1.8 2 0 0 2 2 2 1 Rel homology DNA-binding domain RHD_dimer PF16179.3 MSTRG.25981.2_2 - 7.2e-41 138.3 0.0 1.9e-40 136.9 0.0 1.8 1 0 0 1 1 1 1 Rel homology dimerisation domain ABC_membrane PF00664.21 MSTRG.7349.1_1 - 1.6e-35 123.0 12.0 2.4e-35 122.4 12.0 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.25 MSTRG.7349.1_1 - 5.9e-34 117.4 0.0 1.4e-32 113.0 0.0 2.3 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.17 MSTRG.7349.1_1 - 1.6e-06 27.6 0.3 0.00015 21.1 0.3 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.4 MSTRG.7349.1_1 - 0.0036 16.9 0.2 0.011 15.3 0.2 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.4 MSTRG.7349.1_1 - 0.0063 16.8 0.0 0.014 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain DUF87 PF01935.15 MSTRG.7349.1_1 - 0.02 14.8 0.0 0.059 13.3 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function DUF87 AAA_28 PF13521.4 MSTRG.7349.1_1 - 0.088 12.9 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.4 MSTRG.7349.1_1 - 0.1 12.7 0.0 0.28 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain Crystall PF00030.17 MSTRG.8345.3_3 - 2.2e-117 383.3 0.0 3.9e-19 68.5 0.0 6.6 6 0 0 6 6 6 6 Beta/Gamma crystallin Ricin_B_lectin PF00652.20 MSTRG.8345.3_3 - 5.5e-07 29.8 0.0 1.2e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Tcp11 PF05794.11 MSTRG.4607.3_2 - 0.12 11.4 0.5 0.16 11.0 0.5 1.1 1 0 0 1 1 1 0 T-complex protein 11 PLAC8 PF04749.15 MSTRG.4607.3_3 - 5.6e-15 56.0 12.5 9.5e-15 55.3 12.5 1.4 1 0 0 1 1 1 1 PLAC8 family TPR_1 PF00515.26 MSTRG.6970.2_2 - 1.8e-19 68.5 0.1 0.00029 20.4 0.1 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.6970.2_2 - 6.7e-18 63.2 1.8 0.0034 17.2 0.2 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.6970.2_2 - 1.1e-17 63.0 3.1 0.013 16.2 0.0 6.5 3 2 3 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.6970.2_2 - 6e-15 54.5 0.2 0.00015 21.3 0.0 5.5 5 1 1 6 6 6 2 TPR repeat TPR_8 PF13181.4 MSTRG.6970.2_2 - 1.8e-13 49.4 0.0 0.015 15.4 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.6970.2_2 - 3.9e-13 49.7 1.7 1.9e-06 28.3 0.4 4.3 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.6970.2_2 - 6e-11 42.6 1.2 0.00014 22.2 0.2 3.7 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.6970.2_2 - 1.5e-10 40.6 1.4 0.14 12.4 0.0 5.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.6970.2_2 - 5.5e-09 35.3 1.5 0.022 14.6 0.0 4.9 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.6970.2_2 - 1.3e-08 34.8 3.2 0.0027 17.8 0.1 3.3 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.6970.2_2 - 3e-06 27.4 0.4 32 5.3 0.1 6.3 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_20 PF14561.4 MSTRG.6970.2_2 - 5.9e-06 26.4 1.4 0.31 11.3 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.4 MSTRG.6970.2_2 - 9.8e-06 25.5 4.7 0.037 14.0 0.4 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.6970.2_2 - 3.5e-05 23.4 2.9 0.028 14.2 0.3 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.6970.2_2 - 0.0024 17.9 0.8 1.9 8.6 0.1 2.6 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 MAS20 PF02064.13 MSTRG.6970.2_2 - 0.0035 17.3 0.0 0.21 11.5 0.0 2.3 1 1 1 2 2 2 1 MAS20 protein import receptor TPR_15 PF13429.4 MSTRG.6970.2_2 - 0.017 14.2 0.5 4.8 6.2 0.1 2.5 2 1 1 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.15 MSTRG.6970.2_2 - 0.27 11.5 2.8 22 5.3 0.0 3.2 3 1 0 3 3 3 0 Bacterial transcriptional activator domain SHNi-TPR PF10516.7 MSTRG.6970.2_2 - 8.9 5.7 6.0 60 3.1 0.1 3.2 3 0 0 3 3 3 0 SHNi-TPR DUF1152 PF06626.10 MSTRG.27324.3_1 - 0.21 10.6 0.0 0.33 10.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1152) zf-MIZ PF02891.18 MSTRG.16766.3_1 - 1.6e-22 78.9 4.2 1.6e-22 78.9 4.2 3.2 3 0 0 3 3 3 1 MIZ/SP-RING zinc finger zf-Nse PF11789.6 MSTRG.16766.3_1 - 1.4e-05 24.7 1.0 1.4e-05 24.7 1.0 2.6 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit C1-set PF07654.13 MSTRG.8991.2_1 - 3.6e-13 49.7 0.0 5.4e-13 49.1 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin C1-set domain C2-set_2 PF08205.10 MSTRG.8991.2_1 - 9.8e-05 22.2 0.1 0.00017 21.5 0.1 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 MSTRG.8991.2_1 - 0.0023 18.4 0.1 0.0041 17.6 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain CSD PF00313.20 MSTRG.3266.1_1 - 2.9e-79 260.8 21.9 2.5e-16 59.2 0.5 9.3 9 0 0 9 9 9 9 'Cold-shock' DNA-binding domain S1-like PF14444.4 MSTRG.3266.1_1 - 2.7e-10 40.0 15.5 0.034 14.1 0.0 8.0 9 1 0 9 9 9 4 S1-like SUZ-C PF12901.5 MSTRG.3266.1_1 - 9.1e-10 38.2 0.1 2.6e-09 36.8 0.0 1.9 2 0 0 2 2 2 1 SUZ-C motif CusF_Ec PF11604.6 MSTRG.3266.1_1 - 1.4e-07 31.2 12.5 0.19 11.6 0.1 8.8 10 0 0 10 10 10 1 Copper binding periplasmic protein CusF DUF3857 PF12969.5 MSTRG.3266.1_1 - 0.023 14.6 0.0 0.72 9.8 0.0 2.9 3 0 0 3 3 3 0 Domain of Unknown Function with PDB structure (DUF3857) RsgA_N PF16745.3 MSTRG.3266.1_1 - 0.037 13.6 8.8 5.2 6.7 0.0 6.1 7 0 0 7 7 7 0 RsgA N-terminal domain DUF3093 PF11292.6 MSTRG.3266.1_1 - 0.089 12.9 0.0 4.9 7.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3093) MazE_antitoxin PF04014.16 MSTRG.3266.1_1 - 0.13 12.1 7.0 10 6.0 0.1 4.7 5 0 0 5 5 5 0 Antidote-toxin recognition MazE, bacterial antitoxin OB_RNB PF08206.9 MSTRG.3266.1_1 - 5.4 6.6 17.1 20 4.8 0.3 5.3 6 0 0 6 6 6 0 Ribonuclease B OB domain Fcf1 PF04900.10 MSTRG.7932.1_2 - 1.9e-28 98.7 0.1 1.9e-28 98.7 0.1 2.1 3 0 0 3 3 3 1 Fcf1 DUF3959 PF13105.4 MSTRG.6995.4_2 - 0.016 14.6 0.3 0.03 13.7 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) tRNA-synt_1g PF09334.9 MSTRG.26996.1_2 - 2.2e-148 494.1 0.0 2.8e-148 493.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) WHEP-TRS PF00458.18 MSTRG.26996.1_2 - 8.9e-17 60.9 4.6 2.1e-16 59.7 4.6 1.7 1 0 0 1 1 1 1 WHEP-TRS domain tRNA-synt_1 PF00133.20 MSTRG.26996.1_2 - 2e-08 32.9 1.0 0.0001 20.6 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) GST_C_3 PF14497.4 MSTRG.26996.1_2 - 0.00017 21.6 0.0 0.00096 19.2 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 MSTRG.26996.1_2 - 0.0068 16.5 0.0 0.018 15.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.18 MSTRG.26996.1_2 - 0.02 15.1 0.0 0.047 13.9 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 MSTRG.26996.1_2 - 0.098 12.9 0.0 0.26 11.5 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain zinc-ribbons_6 PF07191.10 MSTRG.26996.1_2 - 1.7 8.5 8.2 5.1 7.0 4.9 2.4 1 1 1 2 2 2 0 zinc-ribbons HypA PF01155.17 MSTRG.26996.1_2 - 2.1 8.3 5.9 2.4 8.1 0.3 2.7 2 1 1 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Radical_SAM PF04055.19 MSTRG.13039.1_2 - 9.5e-17 61.7 0.0 1.6e-16 61.0 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily TRAM PF01938.18 MSTRG.13039.1_2 - 3.7e-13 49.1 0.0 6.9e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 TRAM domain IBR PF01485.19 MSTRG.17661.2_1 - 1.4e-17 63.5 28.2 1.7e-12 47.2 11.9 4.9 4 1 0 4 4 4 2 IBR domain, a half RING-finger domain Vitellogenin_N PF01347.20 MSTRG.29764.1_1 - 1.4e-18 66.6 0.0 1.5e-18 66.5 0.0 1.0 1 0 0 1 1 1 1 Lipoprotein amino terminal region COesterase PF00135.26 MSTRG.6640.1_1 - 1.2e-55 189.3 0.1 1.5e-55 189.0 0.1 1.1 1 0 0 1 1 1 1 Carboxylesterase family HLH PF00010.24 MSTRG.17664.5_1 - 2.2e-11 43.4 0.3 4.5e-11 42.4 0.3 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_3 PF08447.10 MSTRG.14422.1_1 - 4.8e-25 87.5 0.0 5.8e-20 71.2 0.0 2.3 2 0 0 2 2 2 2 PAS fold HIF-1a_CTAD PF08778.8 MSTRG.14422.1_1 - 3.4e-22 77.6 0.8 7.8e-22 76.5 0.8 1.7 1 0 0 1 1 1 1 HIF-1 alpha C terminal transactivation domain PAS_11 PF14598.4 MSTRG.14422.1_1 - 1.5e-21 76.5 0.4 2.2e-18 66.3 0.1 2.3 2 0 0 2 2 2 2 PAS domain HIF-1 PF11413.6 MSTRG.14422.1_1 - 2.6e-16 58.6 5.7 2.6e-16 58.6 5.7 1.9 2 0 0 2 2 2 1 Hypoxia-inducible factor-1 PAS PF00989.23 MSTRG.14422.1_1 - 2.3e-13 50.0 0.0 1.3e-06 28.3 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.5 MSTRG.14422.1_1 - 9.7e-07 28.9 0.0 0.018 15.2 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.8 MSTRG.14422.1_1 - 3.4e-06 27.1 0.0 0.018 15.2 0.0 2.4 2 0 0 2 2 2 2 PAS fold HLH PF00010.24 MSTRG.14422.1_1 - 0.046 13.6 0.2 0.19 11.6 0.1 2.1 2 0 0 2 2 2 0 Helix-loop-helix DNA-binding domain zf-H2C2_2 PF13465.4 MSTRG.1624.1_2 - 4.7e-22 77.2 51.9 9.6e-07 28.9 0.7 7.5 8 0 0 8 8 8 6 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.1624.1_2 - 3.4e-21 74.3 66.0 2e-05 24.7 1.9 8.5 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.1624.1_2 - 1.8e-16 59.2 65.3 0.0025 18.4 1.5 8.7 8 0 0 8 8 8 6 C2H2-type zinc finger zf-met PF12874.5 MSTRG.1624.1_2 - 7.1e-07 29.3 55.8 0.0022 18.2 2.7 7.3 7 0 0 7 7 7 5 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.1624.1_2 - 8.2e-07 29.0 45.1 0.018 15.2 0.3 7.4 6 1 1 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 MSTRG.1624.1_2 - 0.0046 16.5 1.3 0.0046 16.5 1.3 6.3 6 0 0 6 6 6 2 C2H2-type zinc-finger domain BolA PF01722.16 MSTRG.1624.1_2 - 2.1 8.6 8.1 1.1 9.5 0.2 2.9 3 0 0 3 3 3 0 BolA-like protein zf-C2H2 PF00096.24 MSTRG.15781.1_2 - 6.8e-21 73.4 20.3 4e-05 23.7 0.9 5.9 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.15781.1_2 - 7.1e-21 73.5 21.1 3.4e-08 33.4 0.3 6.3 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.15781.1_2 - 8.2e-18 63.4 13.8 0.00067 20.1 0.5 5.6 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.15781.1_2 - 3.1e-06 26.8 9.9 0.42 10.5 0.3 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.5 MSTRG.15781.1_2 - 1.1e-05 25.5 21.0 0.031 14.5 0.3 5.9 6 0 0 6 6 5 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.15781.1_2 - 1.5e-05 25.1 4.0 1.4 9.2 0.1 4.8 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 MSTRG.15781.1_2 - 0.00043 19.8 10.6 0.016 14.9 1.0 4.4 3 0 0 3 3 3 1 C2H2-type zinc-finger domain zinc_ribbon_15 PF17032.3 MSTRG.15781.1_2 - 0.0022 18.6 2.1 0.89 10.2 0.2 2.7 2 0 0 2 2 2 2 zinc-ribbon family zf-C2H2_11 PF16622.3 MSTRG.15781.1_2 - 0.0042 16.7 14.0 0.1 12.2 0.6 4.6 4 0 0 4 4 4 1 zinc-finger C2H2-type GAGA PF09237.9 MSTRG.15781.1_2 - 0.01 15.5 0.4 0.031 13.9 0.4 1.8 1 0 0 1 1 1 0 GAGA factor DUF3268 PF11672.6 MSTRG.15781.1_2 - 0.018 15.2 1.4 0.7 10.1 0.2 2.3 2 0 0 2 2 2 0 zinc-finger-containing domain zf-C2H2_2 PF12756.5 MSTRG.15781.1_2 - 0.022 14.9 9.3 18 5.6 0.3 4.3 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-LYAR PF08790.9 MSTRG.15781.1_2 - 0.078 12.8 1.2 41 4.1 0.0 3.7 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger C1_1 PF00130.20 MSTRG.15781.1_2 - 0.1 12.4 2.8 2.7 7.8 0.2 3.1 1 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn-ribbon_8 PF09723.8 MSTRG.15781.1_2 - 0.38 10.8 4.7 0.54 10.3 0.2 2.8 1 1 2 3 3 3 0 Zinc ribbon domain zf-C2HE PF16278.3 MSTRG.15781.1_2 - 0.74 10.2 11.8 7.1 7.0 0.2 4.1 2 2 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger bZIP_1 PF00170.19 MSTRG.23621.3_2 - 3.6e-12 46.1 12.5 9.3e-12 44.7 12.5 1.7 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 MSTRG.23621.3_2 - 2.3e-09 37.0 7.4 2.3e-09 37.0 7.4 1.8 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.15 MSTRG.23621.3_2 - 0.00023 21.5 9.3 0.00051 20.4 9.3 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor KASH_CCD PF14662.4 MSTRG.23621.3_2 - 0.058 13.1 6.7 0.11 12.2 6.7 1.4 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH DUF724 PF05266.12 MSTRG.23621.3_2 - 0.17 11.6 2.8 0.28 10.8 2.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF4200 PF13863.4 MSTRG.23621.3_2 - 0.25 11.6 7.3 0.45 10.8 7.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) DMPK_coil PF08826.8 MSTRG.23621.3_2 - 0.69 9.9 5.8 1.9 8.5 5.8 1.8 1 0 0 1 1 1 0 DMPK coiled coil domain like ADIP PF11559.6 MSTRG.23621.3_2 - 0.85 9.6 10.3 1.4 8.9 10.3 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding GIT_CC PF16559.3 MSTRG.23621.3_2 - 3 7.8 7.1 0.27 11.2 1.8 2.1 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF676 PF05057.12 MSTRG.28858.1_1 - 0.086 12.2 0.0 0.087 12.2 0.0 1.1 1 0 0 1 1 1 0 Putative serine esterase (DUF676) LRR_8 PF13855.4 MSTRG.2994.1_1 - 5.7e-28 96.3 16.0 1.5e-17 63.0 4.7 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.5 MSTRG.2994.1_1 - 1.8e-11 43.9 11.4 1.1e-07 31.8 3.4 3.2 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 MSTRG.2994.1_1 - 1.5e-08 34.5 0.2 3.5e-08 33.3 0.2 1.5 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) GPS PF01825.19 MSTRG.2994.1_1 - 1.8e-06 28.3 0.1 1.8e-06 28.3 0.1 3.7 3 0 0 3 3 2 1 GPCR proteolysis site, GPS, motif Ig_2 PF13895.4 MSTRG.2994.1_1 - 4.2e-06 26.9 1.1 1.3e-05 25.3 0.1 2.5 3 0 0 3 3 1 1 Immunoglobulin domain LRR_1 PF00560.31 MSTRG.2994.1_1 - 7e-06 25.7 6.8 0.21 12.1 0.1 4.9 4 0 0 4 4 4 2 Leucine Rich Repeat Ig_3 PF13927.4 MSTRG.2994.1_1 - 1.5e-05 25.4 0.1 0.00018 21.9 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 MSTRG.2994.1_1 - 1.8e-05 24.7 1.7 0.00096 19.1 0.2 3.0 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 MSTRG.2994.1_1 - 0.0002 21.2 0.0 0.00046 20.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain HRM PF02793.20 MSTRG.2994.1_1 - 0.00029 21.0 0.4 0.00077 19.6 0.4 1.8 1 0 0 1 1 1 1 Hormone receptor domain LRR_9 PF14580.4 MSTRG.2994.1_1 - 0.0019 17.6 0.8 0.0034 16.8 0.8 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRRCT PF01463.22 MSTRG.2994.1_1 - 0.006 16.9 0.3 0.033 14.6 0.3 2.4 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain LRR_6 PF13516.4 MSTRG.2994.1_1 - 0.64 10.1 12.1 19 5.5 0.2 4.4 4 0 0 4 4 4 0 Leucine Rich repeat 7tm_2 PF00002.22 MSTRG.2994.1_1 - 9.5 5.3 10.7 16 4.6 10.7 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (Secretin family) IncA PF04156.12 MSTRG.2994.1_2 - 0.029 14.0 5.8 0.065 12.9 5.8 1.5 1 0 0 1 1 1 0 IncA protein DUF308 PF03729.11 MSTRG.2994.1_2 - 1.2 9.4 8.1 0.81 9.9 1.7 2.3 2 0 0 2 2 2 0 Short repeat of unknown function (DUF308) PBC PF03792.11 MSTRG.12728.1_1 - 9.2e-32 110.2 2.2 9.2e-32 110.2 2.2 1.5 2 0 0 2 2 2 1 PBC domain Homeobox PF00046.27 MSTRG.12728.1_1 - 4.7e-19 67.8 1.6 9.4e-19 66.9 1.6 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 MSTRG.12728.1_1 - 1.8e-15 56.4 0.0 4.3e-15 55.2 0.0 1.7 1 0 0 1 1 1 1 Homeobox KN domain YdaS_antitoxin PF15943.3 MSTRG.12728.1_1 - 0.014 15.1 0.0 0.046 13.4 0.0 1.8 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Maf1 PF09174.8 MSTRG.5229.1_2 - 2.8e-51 173.6 0.1 3.7e-51 173.2 0.1 1.1 1 0 0 1 1 1 1 Maf1 regulator TPR_1 PF00515.26 MSTRG.6459.2_3 - 2e-10 39.9 4.7 1.9e-05 24.1 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.6459.2_3 - 6.4e-09 35.1 0.5 0.055 13.5 0.5 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat zf-C2H2_jaz PF12171.6 MSTRG.6459.2_3 - 7.1e-08 32.4 1.0 2.7e-07 30.6 1.0 2.2 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-CCCH PF00642.22 MSTRG.6459.2_3 - 2.5e-07 30.3 8.4 0.033 14.0 0.2 3.8 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) TPR_8 PF13181.4 MSTRG.6459.2_3 - 1.7e-06 27.6 4.6 0.0034 17.3 0.4 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.6459.2_3 - 1.8e-06 28.0 4.8 4.5e-06 26.6 4.8 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.4 MSTRG.6459.2_3 - 0.00089 19.4 0.7 0.0097 16.0 0.3 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.6459.2_3 - 0.0066 16.6 1.3 0.039 14.2 0.2 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat zf-C2H2_4 PF13894.4 MSTRG.6459.2_3 - 0.0068 17.0 0.5 0.16 12.7 0.5 3.6 1 0 0 1 1 1 1 C2H2-type zinc finger Fis1_TPR_C PF14853.4 MSTRG.6459.2_3 - 0.0098 15.8 5.0 0.23 11.4 1.5 2.4 1 1 1 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.6459.2_3 - 0.023 14.4 0.0 0.11 12.3 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3856 PF12968.5 MSTRG.6459.2_3 - 0.025 14.5 0.0 0.1 12.5 0.0 2.0 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) SRP_TPR_like PF17004.3 MSTRG.6459.2_3 - 0.026 14.4 0.4 0.054 13.4 0.4 1.5 1 0 0 1 1 1 0 Putative TPR-like repeat Lustrin_cystein PF14625.4 MSTRG.6459.2_3 - 0.034 14.4 4.3 6.2 7.2 0.0 3.7 3 0 0 3 3 2 0 Lustrin, cysteine-rich repeated domain zf-C2H2 PF00096.24 MSTRG.6459.2_3 - 0.61 10.5 6.4 0.36 11.3 1.6 3.5 2 0 0 2 2 1 0 Zinc finger, C2H2 type DUF3808 PF10300.7 MSTRG.6459.2_3 - 0.77 8.3 5.5 0.076 11.6 0.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3808) Ig_3 PF13927.4 MSTRG.27710.1_1 - 2.7e-11 43.8 0.4 0.00029 21.3 0.0 3.8 3 1 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 MSTRG.27710.1_1 - 4.4e-09 36.2 0.2 0.00034 20.5 0.0 3.7 3 1 1 4 4 4 3 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.27710.1_1 - 1.3e-08 34.9 0.3 0.015 15.5 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 MSTRG.27710.1_1 - 1.7e-07 31.2 0.3 0.001 19.1 0.3 2.9 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.10 MSTRG.27710.1_1 - 3.9e-07 29.9 2.0 0.015 15.3 0.1 3.1 2 1 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Atx10homo_assoc PF09759.7 MSTRG.1616.1_3 - 1e-38 131.3 3.1 8.5e-34 115.5 0.1 3.6 3 1 1 4 4 4 3 Spinocerebellar ataxia type 10 protein domain Synaptobrevin PF00957.19 MSTRG.16006.2_2 - 8.9e-29 99.0 0.7 1.5e-28 98.2 0.7 1.4 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.4 MSTRG.16006.2_2 - 2.8e-27 94.4 0.8 5.3e-27 93.5 0.8 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain Phospholamban PF04272.12 MSTRG.16006.2_2 - 0.012 14.9 1.7 0.012 14.9 1.7 1.9 2 0 0 2 2 2 0 Phospholamban DUF481 PF04338.10 MSTRG.16006.2_2 - 0.1 12.5 0.1 0.15 12.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF481 OHCU_decarbox PF09349.8 MSTRG.5580.2_2 - 3e-41 141.4 0.0 5.1e-41 140.6 0.0 1.4 1 0 0 1 1 1 1 OHCU decarboxylase THAP PF05485.10 MSTRG.5580.2_2 - 3.5e-06 27.8 0.1 2.4e-05 25.1 0.0 2.4 2 0 0 2 2 2 1 THAP domain Tnp_P_element PF12017.6 MSTRG.5580.2_2 - 0.00011 21.6 0.1 0.00024 20.5 0.1 1.5 1 1 0 1 1 1 1 Transposase protein HMG_box PF00505.17 MSTRG.17417.1_1 - 5e-23 81.2 3.7 1.9e-22 79.3 3.7 2.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 MSTRG.17417.1_1 - 3.2e-09 37.1 1.0 3.2e-09 37.1 1.0 3.5 3 0 0 3 3 3 1 HMG-box domain UreF PF01730.14 MSTRG.17417.1_1 - 0.014 15.9 1.3 0.031 14.7 1.3 1.5 1 0 0 1 1 1 0 UreF RNF111_N PF15303.4 MSTRG.17417.1_1 - 0.073 12.7 4.8 12 5.4 4.0 2.6 2 0 0 2 2 2 0 E3 ubiquitin-protein ligase Arkadia N-terminus DUF3347 PF11827.6 MSTRG.17417.1_1 - 0.26 11.3 13.2 2.2 8.3 6.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3347) DUF4061 PF13270.4 MSTRG.17417.1_1 - 1.6 9.1 18.4 11 6.4 0.3 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4061) Ribosomal_L19e PF01280.18 MSTRG.467.1_2 - 0.12 12.3 0.1 0.23 11.4 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein L19e Peptidase_S41_N PF11918.6 MSTRG.467.1_3 - 5.4e-47 159.1 0.8 3.9e-37 127.2 0.0 2.9 3 0 0 3 3 3 2 N-terminal domain of Peptidase_S41 in eukaryotic IRBP Peptidase_S41 PF03572.16 MSTRG.467.1_3 - 3e-43 147.1 0.1 1.7e-20 73.1 0.0 2.1 2 0 0 2 2 2 2 Peptidase family S41 7tm_1 PF00001.19 MSTRG.15035.1_1 - 4.7e-25 88.2 10.5 4.7e-25 88.2 10.5 1.7 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) zf-CCCH PF00642.22 MSTRG.10007.1_3 - 0.0022 17.7 27.7 0.0097 15.7 1.0 5.0 4 1 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.3 MSTRG.10007.1_3 - 0.011 15.8 20.3 0.49 10.6 6.7 2.9 2 1 0 2 2 2 0 Zinc-finger containing family Torus PF16131.3 MSTRG.10007.1_3 - 0.014 16.0 21.1 2.2 8.9 0.2 4.3 2 2 2 4 4 4 0 Torus domain zf-CCCH_2 PF14608.4 MSTRG.10007.1_3 - 0.25 11.7 30.7 1.2 9.6 2.5 4.9 4 0 0 4 4 4 0 RNA-binding, Nab2-type zinc finger OST-HTH PF12872.5 MSTRG.3307.2_1 - 4.9e-13 48.6 0.0 7.1e-13 48.1 0.0 1.2 1 0 0 1 1 1 1 OST-HTH/LOTUS domain API5 PF05918.9 MSTRG.3307.2_1 - 0.028 13.1 0.9 0.033 12.9 0.9 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) START PF01852.17 MSTRG.25703.1_1 - 3.4e-13 49.3 1.4 1.2e-12 47.6 1.4 1.8 1 1 0 1 1 1 1 START domain RhoGAP PF00620.25 MSTRG.25703.1_1 - 9.6e-13 48.1 0.1 1.8e-12 47.2 0.1 1.4 1 0 0 1 1 1 1 RhoGAP domain mono-CXXC PF15626.4 MSTRG.25703.1_3 - 0.097 12.9 3.9 0.23 11.7 0.4 2.7 2 0 0 2 2 2 0 single CXXC unit DUF2684 PF10885.6 MSTRG.16893.1_3 - 0.0076 16.4 0.1 0.017 15.3 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2684) WD40 PF00400.30 MSTRG.1298.1_3 - 0.0022 18.7 5.0 0.0094 16.7 1.3 2.4 2 2 0 2 2 2 1 WD domain, G-beta repeat PQQ_3 PF13570.4 MSTRG.1298.1_3 - 0.019 15.3 0.2 0.6 10.5 0.0 2.4 2 1 0 2 2 2 0 PQQ-like domain CH PF00307.29 MSTRG.7461.1_1 - 2.5e-83 275.3 0.4 1.7e-23 82.7 0.1 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.4 MSTRG.7461.1_1 - 3.5e-12 46.5 0.1 8.7e-12 45.2 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 MSTRG.7461.1_1 - 4.5e-12 44.5 2.6 3.9e-05 22.8 0.1 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 MSTRG.7461.1_1 - 8.3e-09 34.6 1.5 0.0011 18.6 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain CAMSAP_CH PF11971.6 MSTRG.7461.1_1 - 1.7e-05 24.4 0.0 0.0061 16.2 0.0 3.1 3 0 0 3 3 3 1 CAMSAP CH domain EF-hand_8 PF13833.4 MSTRG.7461.1_1 - 8.5e-05 22.1 0.3 0.023 14.3 0.0 2.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.7461.1_1 - 0.0003 20.0 9.6 0.0065 15.8 0.1 3.4 4 0 0 4 4 4 2 EF hand Peptidase_S8 PF00082.20 MSTRG.11357.3_3 - 1.1e-85 287.4 2.0 1.8e-85 286.7 2.0 1.3 1 0 0 1 1 1 1 Subtilase family TPPII PF12580.6 MSTRG.11357.3_3 - 1e-77 259.8 0.1 2.5e-77 258.5 0.0 1.7 2 0 0 2 2 2 1 Tripeptidyl peptidase II TPPII_N PF12583.6 MSTRG.11357.3_3 - 4.6 7.7 6.5 0.19 12.2 0.4 1.7 2 0 0 2 2 2 0 Tripeptidyl peptidase II N terminal BTG PF07742.10 MSTRG.7940.1_1 - 6.6e-35 119.3 0.0 1.1e-34 118.6 0.0 1.4 1 0 0 1 1 1 1 BTG family PAM2 PF07145.13 MSTRG.7940.1_1 - 1.9e-09 36.4 1.0 7.2e-05 22.1 0.3 2.9 2 0 0 2 2 2 2 Ataxin-2 C-terminal region Med12-LCEWAV PF12145.6 MSTRG.7271.4_3 - 1.4e-174 581.3 0.3 3.2e-132 441.6 0.5 3.9 3 0 0 3 3 3 2 Eukaryotic Mediator 12 subunit domain Med12-PQL PF12144.6 MSTRG.7271.4_3 - 1.9e-80 269.5 49.3 1.9e-80 269.5 49.3 5.8 4 2 1 5 5 5 1 Eukaryotic Mediator 12 catenin-binding domain Med12 PF09497.8 MSTRG.7271.4_3 - 1.9e-13 50.3 0.1 4.4e-13 49.2 0.1 1.6 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 IRK PF01007.18 MSTRG.6856.1_2 - 1.9e-53 181.4 0.0 2.2e-53 181.2 0.0 1.0 1 0 0 1 1 1 1 Inward rectifier potassium channel fn3 PF00041.19 MSTRG.29399.1_1 - 4.5e-11 42.8 0.0 6.3e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Fibronectin type III domain Ank_2 PF12796.5 MSTRG.17667.3_1 - 2.6e-07 31.0 0.3 3.8e-07 30.5 0.3 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.28 MSTRG.17667.3_1 - 5.9e-07 29.5 0.4 5.5e-05 23.3 0.1 2.4 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.4 MSTRG.17667.3_1 - 1e-05 25.6 0.0 2e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.17667.3_1 - 2.7e-05 24.1 0.3 0.015 15.7 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.4 MSTRG.17667.3_1 - 3e-05 24.3 0.1 0.0002 21.7 0.1 2.1 1 1 0 1 1 1 1 Ankyrin repeats (many copies) DUF1340 PF07067.9 MSTRG.17667.3_1 - 0.049 12.9 0.0 0.094 11.9 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1340) DHO_dh PF01180.19 MSTRG.7043.1_1 - 3.5e-34 118.2 0.0 1e-33 116.7 0.0 1.8 2 0 0 2 2 2 1 Dihydroorotate dehydrogenase Fer4_20 PF14691.4 MSTRG.7043.1_1 - 2.8e-32 110.7 0.1 2.8e-32 110.7 0.1 2.6 3 0 0 3 3 2 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Fer4_21 PF14697.4 MSTRG.7043.1_1 - 2.8e-23 81.7 11.6 2.8e-23 81.7 11.6 4.4 5 1 0 5 5 4 1 4Fe-4S dicluster domain Pyr_redox_2 PF07992.12 MSTRG.7043.1_1 - 5.9e-13 48.6 0.0 1.3e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_10 PF13237.4 MSTRG.7043.1_1 - 1.8e-06 27.8 21.7 8.2e-05 22.5 8.6 3.3 2 1 0 2 2 2 2 4Fe-4S dicluster domain Dus PF01207.15 MSTRG.7043.1_1 - 6.6e-06 25.3 0.0 4.5e-05 22.6 0.0 2.0 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) Fer4_7 PF12838.5 MSTRG.7043.1_1 - 2.5e-05 24.7 9.7 2.5e-05 24.7 9.7 4.1 3 1 0 3 3 2 1 4Fe-4S dicluster domain Pyr_redox_3 PF13738.4 MSTRG.7043.1_1 - 2.8e-05 23.4 0.0 0.06 12.4 0.0 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.4 MSTRG.7043.1_1 - 5.3e-05 23.2 0.0 0.00012 22.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Fer4_2 PF12797.5 MSTRG.7043.1_1 - 0.0011 18.8 11.5 0.0043 16.9 1.9 6.0 6 0 0 6 6 6 3 4Fe-4S binding domain Fer4_6 PF12837.5 MSTRG.7043.1_1 - 0.0014 18.5 2.0 0.0014 18.5 2.0 4.9 5 0 0 5 5 3 2 4Fe-4S binding domain Fer4_9 PF13187.4 MSTRG.7043.1_1 - 0.0057 16.7 10.7 0.0057 16.7 10.7 3.6 3 1 1 4 4 3 1 4Fe-4S dicluster domain Pyr_redox PF00070.25 MSTRG.7043.1_1 - 0.096 13.1 0.0 4.7 7.7 0.0 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase PcrB PF01884.15 MSTRG.7043.1_1 - 0.19 11.0 0.0 7.2 5.9 0.0 2.3 2 0 0 2 2 2 0 PcrB family Fer4_17 PF13534.4 MSTRG.7043.1_1 - 0.38 11.2 24.4 0.48 10.9 1.0 4.2 3 1 1 4 4 4 0 4Fe-4S dicluster domain Fer4_8 PF13183.4 MSTRG.7043.1_1 - 1.9 8.9 24.1 0.082 13.2 1.0 4.0 3 1 1 4 4 4 0 4Fe-4S dicluster domain MMR_HSR1 PF01926.21 MSTRG.23294.1_2 - 2.1e-13 50.2 0.0 9.8e-12 44.8 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.16 MSTRG.23294.1_2 - 0.00032 20.1 0.1 0.0029 17.0 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.25 MSTRG.23294.1_2 - 0.042 13.2 0.0 0.14 11.6 0.0 1.8 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain DUF258 PF03193.14 MSTRG.23294.1_2 - 0.043 13.6 0.0 1.7 8.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Dynamin_N PF00350.21 MSTRG.23294.1_2 - 0.27 11.1 4.5 0.05 13.5 0.4 1.9 2 1 0 2 2 2 0 Dynamin family Pkinase_Tyr PF07714.15 MSTRG.16706.1_1 - 3e-37 128.2 0.0 3.3e-37 128.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.16706.1_1 - 1.5e-09 37.4 0.0 1.9e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Iso_dh PF00180.18 MSTRG.14443.1_2 - 2.6e-78 263.5 0.0 3.1e-78 263.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase zf-C2H2 PF00096.24 MSTRG.21738.4_2 - 4.2e-11 42.5 34.6 7.1e-06 26.1 3.2 5.4 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.21738.4_2 - 6.3e-06 26.3 9.3 3.1e-05 24.1 1.6 5.5 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.21738.4_2 - 0.0084 16.7 2.3 0.0084 16.7 2.3 6.8 7 0 0 7 7 7 4 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.21738.4_2 - 0.0087 15.9 5.0 0.049 13.5 1.2 2.8 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.21738.4_2 - 0.021 15.0 1.0 0.021 15.0 1.0 3.7 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.21738.4_2 - 0.023 14.9 1.2 0.023 14.9 1.2 3.3 2 0 0 2 2 2 0 Zinc-finger of C2H2 type 5-FTHF_cyc-lig PF01812.18 MSTRG.23152.1_3 - 9.1e-32 110.3 0.0 1.4e-31 109.7 0.0 1.3 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family RRM_1 PF00076.20 MSTRG.23152.1_3 - 0.00073 19.2 0.0 0.0017 18.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fibrinogen_C PF00147.16 MSTRG.8408.1_1 - 1.9e-48 165.0 4.3 2.4e-48 164.7 4.3 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF1658 PF07871.9 MSTRG.22279.1_2 - 0.07 13.0 0.7 0.14 12.0 0.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1658) DHR-2 PF06920.11 MSTRG.22279.1_3 - 3.7e-23 81.9 0.8 4e-23 81.7 0.8 1.0 1 0 0 1 1 1 1 Dock homology region 2 VCBS PF13517.4 MSTRG.11263.1_1 - 8.3e-20 71.0 21.5 6.4e-05 23.3 0.5 6.4 4 1 3 7 7 7 7 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.21 MSTRG.11263.1_1 - 2.7e-14 52.8 11.2 0.012 15.6 0.2 6.2 6 0 0 6 6 6 4 FG-GAP repeat TcdB_toxin_midN PF12256.6 MSTRG.11263.1_1 - 0.03 13.6 1.0 8.4 5.6 0.0 3.1 3 1 1 4 4 4 0 Insecticide toxin TcdB middle/N-terminal region Cadherin PF00028.15 MSTRG.26102.1_3 - 8.9e-86 282.4 5.4 3.3e-17 62.6 0.0 6.2 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 MSTRG.26102.1_3 - 2.3e-33 113.7 3.2 2.3e-26 91.3 0.3 5.6 6 0 0 6 6 6 2 Cadherin-like Cadherin_C_2 PF16492.3 MSTRG.26102.1_3 - 3.6e-08 33.9 0.1 1.1e-07 32.4 0.1 1.9 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 MSTRG.26102.1_3 - 8.7e-05 22.4 11.4 2.7 7.9 0.0 6.0 6 1 0 6 6 6 4 Cadherin-like Sugar_tr PF00083.22 MSTRG.4026.1_2 - 5.2e-82 276.0 12.3 2.6e-81 273.7 12.3 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 MSTRG.4026.1_2 - 3.5e-24 85.3 34.1 5.5e-23 81.3 28.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.5 MSTRG.4026.1_2 - 0.025 13.3 5.2 2.1 7.0 0.0 3.2 2 1 1 3 3 3 0 MFS_1 like family Tissue_fac PF01108.15 MSTRG.4026.1_2 - 0.13 12.0 0.2 0.29 10.8 0.2 1.6 1 0 0 1 1 1 0 Tissue factor Trp_oprn_chp PF09534.8 MSTRG.4026.1_2 - 2.5 7.7 7.0 0.47 10.1 0.6 2.7 2 1 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Zf_RING PF16744.3 MSTRG.3221.1_1 - 0.86 9.6 4.8 18 5.4 2.8 2.4 2 0 0 2 2 2 0 KIAA1045 RING finger DUF2448 PF10476.7 MSTRG.3221.1_2 - 4e-56 190.1 7.2 5.8e-56 189.5 6.4 1.6 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2448) Ima1_N PF09779.7 MSTRG.3221.1_2 - 7.9e-34 117.3 7.7 1.3e-33 116.6 7.7 1.3 1 0 0 1 1 1 1 Ima1 N-terminal domain Pox_A3L PF05288.9 MSTRG.3221.1_2 - 0.032 14.1 0.2 0.087 12.7 0.2 1.7 1 0 0 1 1 1 0 Poxvirus A3L Protein NO_synthase PF02898.13 MSTRG.16777.1_3 - 3.6e-192 638.1 0.0 5.1e-192 637.6 0.0 1.2 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain FAD_binding_1 PF00667.18 MSTRG.16777.1_3 - 4.1e-80 268.4 0.1 7.3e-80 267.6 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.23 MSTRG.16777.1_3 - 5.8e-53 178.8 0.1 1.1e-52 177.9 0.1 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.19 MSTRG.16777.1_3 - 7.4e-20 71.5 0.0 1.7e-19 70.4 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Kinesin PF00225.21 MSTRG.21267.1_2 - 2.7e-115 384.7 2.7 3.1e-115 384.5 2.7 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 MSTRG.21267.1_2 - 4.7e-24 84.9 0.4 4.7e-24 84.9 0.4 1.9 2 0 0 2 2 2 1 Microtubule binding Kinesin_assoc PF16183.3 MSTRG.21267.1_2 - 6.3e-15 55.6 3.0 7.9e-15 55.3 0.3 2.2 2 0 0 2 2 2 1 Kinesin-associated IstB_IS21 PF01695.15 MSTRG.21267.1_2 - 0.14 11.8 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein TSC22 PF01166.16 MSTRG.29394.1_1 - 8.3e-22 77.1 4.1 1.4e-21 76.4 4.1 1.3 1 0 0 1 1 1 1 TSC-22/dip/bun family ZapB PF06005.10 MSTRG.29394.1_1 - 0.00034 20.9 0.4 0.00063 20.0 0.4 1.4 1 0 0 1 1 1 1 Cell division protein ZapB DUF972 PF06156.11 MSTRG.29394.1_1 - 0.0018 18.7 0.1 0.003 18.0 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF972) Nnf1 PF03980.12 MSTRG.29394.1_1 - 0.0026 18.0 0.3 0.0035 17.6 0.3 1.2 1 0 0 1 1 1 1 Nnf1 SOGA PF11365.6 MSTRG.29394.1_1 - 0.0032 18.4 0.2 0.0052 17.7 0.2 1.3 1 0 0 1 1 1 1 Protein SOGA K-box PF01486.15 MSTRG.29394.1_1 - 0.005 16.9 1.1 0.044 13.8 1.4 2.0 2 0 0 2 2 2 1 K-box region DivIC PF04977.13 MSTRG.29394.1_1 - 0.012 15.2 2.7 0.021 14.4 2.7 1.3 1 0 0 1 1 1 0 Septum formation initiator Lebercilin PF15619.4 MSTRG.29394.1_1 - 0.032 13.8 3.7 0.054 13.0 3.7 1.3 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease GIT_CC PF16559.3 MSTRG.29394.1_1 - 0.31 11.0 2.0 0.59 10.1 2.0 1.4 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Met_10 PF02475.14 MSTRG.14426.4_1 - 1.5e-06 28.0 0.0 2.2e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 Met-10+ like-protein Met_10 PF02475.14 MSTRG.14426.4_3 - 5.8e-44 150.1 0.0 8.2e-44 149.6 0.0 1.1 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_15 PF09445.8 MSTRG.14426.4_3 - 0.00014 21.6 0.0 0.00024 20.8 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.11 MSTRG.14426.4_3 - 0.0011 18.3 0.0 0.0016 17.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) TRM PF02005.14 MSTRG.14426.4_3 - 0.0063 15.6 0.0 0.0093 15.0 0.0 1.2 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase MethyltransfD12 PF02086.13 MSTRG.14426.4_3 - 0.033 13.7 0.0 0.051 13.1 0.0 1.2 1 0 0 1 1 1 0 D12 class N6 adenine-specific DNA methyltransferase Cons_hypoth95 PF03602.13 MSTRG.14426.4_3 - 0.11 12.0 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 TBP PF00352.19 MSTRG.10139.2_1 - 4.1e-18 65.0 0.1 3e-17 62.2 0.0 2.2 3 0 0 3 3 3 1 Transcription factor TFIID (or TATA-binding protein, TBP) TBP PF00352.19 MSTRG.10139.2_3 - 1.5e-06 27.9 0.2 2.6e-06 27.2 0.2 1.3 1 0 0 1 1 1 1 Transcription factor TFIID (or TATA-binding protein, TBP) Pkinase_Tyr PF07714.15 MSTRG.23865.1_3 - 2.4e-101 338.3 0.0 3.4e-101 337.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.4 MSTRG.23865.1_3 - 1e-49 166.9 10.1 1.1e-12 48.2 0.1 7.7 7 1 0 7 7 7 6 Immunoglobulin domain I-set PF07679.14 MSTRG.23865.1_3 - 5e-47 157.8 1.7 1.8e-15 56.6 0.0 7.4 6 2 0 6 6 6 6 Immunoglobulin I-set domain Pkinase PF00069.23 MSTRG.23865.1_3 - 5.2e-41 140.6 0.0 1.3e-28 99.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ig_2 PF13895.4 MSTRG.23865.1_3 - 9.3e-37 125.1 8.8 1.5e-10 41.1 0.2 8.6 8 1 0 8 8 8 6 Immunoglobulin domain ig PF00047.23 MSTRG.23865.1_3 - 2.2e-30 104.5 9.9 5.5e-08 32.7 0.2 9.2 7 3 0 7 7 7 5 Immunoglobulin domain V-set PF07686.15 MSTRG.23865.1_3 - 5.2e-12 45.8 6.9 0.32 11.0 0.1 7.6 6 2 1 7 7 7 4 Immunoglobulin V-set domain Ig_5 PF16681.3 MSTRG.23865.1_3 - 5.9e-08 32.9 0.2 0.88 9.9 0.0 6.3 6 1 0 6 6 6 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 MSTRG.23865.1_3 - 4.6e-06 26.5 3.3 2.2 8.3 0.0 6.1 6 0 0 6 6 6 1 Izumo-like Immunoglobulin domain C1-set PF07654.13 MSTRG.23865.1_3 - 7.1e-05 23.1 5.9 1.3 9.4 0.0 5.8 8 0 0 8 8 6 1 Immunoglobulin C1-set domain Sp38 PF07354.10 MSTRG.23865.1_3 - 0.13 11.0 0.0 19 3.9 0.0 2.8 3 0 0 3 3 3 0 Zona-pellucida-binding protein (Sp38) Amidohydro_1 PF01979.18 MSTRG.16920.1_3 - 2.2e-68 231.0 0.0 2.8e-68 230.6 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.9 MSTRG.16920.1_3 - 7.5e-08 32.1 0.0 1.6e-05 24.4 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Beach PF02138.16 MSTRG.18565.1_1 - 2.7e-127 423.8 0.1 4.1e-127 423.2 0.1 1.3 1 0 0 1 1 1 1 Beige/BEACH domain FYVE PF01363.19 MSTRG.18565.1_1 - 5.2e-17 61.6 16.6 5.2e-17 61.6 16.6 2.3 2 0 0 2 2 2 1 FYVE zinc finger PH_BEACH PF14844.4 MSTRG.18565.1_1 - 5.8e-14 51.9 0.1 2.3e-13 50.0 0.0 2.0 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH WD40 PF00400.30 MSTRG.18565.1_1 - 2e-08 34.6 13.9 0.00037 21.1 0.2 5.8 5 0 0 5 5 5 2 WD domain, G-beta repeat DUF4800 PF16057.3 MSTRG.18565.1_1 - 0.0085 15.3 1.0 0.017 14.3 1.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4800) Sugar_tr PF00083.22 MSTRG.23127.1_3 - 8.2e-89 298.4 28.1 1.1e-88 297.9 28.1 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 MSTRG.23127.1_3 - 6.9e-17 61.3 41.0 2.2e-13 49.7 15.7 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily BORG_CEP PF14957.4 MSTRG.14695.1_2 - 2.4e-28 99.5 3.5 1.7e-27 96.7 3.5 2.2 1 1 0 1 1 1 1 Cdc42 effector PBD PF00786.26 MSTRG.14695.1_2 - 6e-08 32.9 0.0 1.4e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain GET2 PF08690.8 MSTRG.14695.1_2 - 0.072 12.6 0.3 0.12 12.0 0.3 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 PAZ PF02170.20 MSTRG.14695.1_2 - 0.073 12.8 0.4 0.12 12.1 0.4 1.3 1 0 0 1 1 1 0 PAZ domain LSM PF01423.20 MSTRG.2875.1_1 - 4.6e-14 51.7 0.3 1.8e-13 49.9 0.1 2.1 2 0 0 2 2 2 1 LSM domain Kelch_3 PF13415.4 MSTRG.8752.1_2 - 1.7e-24 85.4 11.6 1.5e-07 31.3 0.1 6.4 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_4 PF13418.4 MSTRG.8752.1_2 - 7.4e-24 83.3 10.1 2e-07 30.7 0.1 6.8 5 2 2 7 7 7 5 Galactose oxidase, central domain Kelch_6 PF13964.4 MSTRG.8752.1_2 - 1.1e-21 76.2 18.1 5.4e-05 23.2 0.0 7.0 4 2 2 6 6 6 5 Kelch motif Kelch_5 PF13854.4 MSTRG.8752.1_2 - 2.7e-21 74.9 3.8 9.8e-06 25.3 0.1 5.9 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.13 MSTRG.8752.1_2 - 5e-17 61.0 21.8 1.1e-05 25.1 0.0 6.6 6 1 0 6 6 6 5 Kelch motif Kelch_1 PF01344.23 MSTRG.8752.1_2 - 4.4e-16 58.0 22.2 0.00037 19.9 0.0 6.4 6 1 0 6 6 6 4 Kelch motif PQQ_3 PF13570.4 MSTRG.8752.1_2 - 0.09 13.2 0.2 24 5.4 0.1 3.7 4 0 0 4 4 4 0 PQQ-like domain DEAD_2 PF06733.13 MSTRG.19792.1_2 - 2.1e-51 173.9 0.4 2.1e-51 173.9 0.4 1.7 2 0 0 2 2 2 1 DEAD_2 DEAD PF00270.27 MSTRG.19792.1_2 - 0.00036 20.2 0.5 0.037 13.6 0.5 2.5 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.13 MSTRG.19792.1_2 - 0.0012 18.7 2.5 1.7 8.4 0.0 3.0 2 1 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_22 PF13401.4 MSTRG.19792.1_2 - 0.0065 16.6 2.6 0.037 14.2 0.0 2.6 2 1 0 2 2 2 1 AAA domain PhoH PF02562.14 MSTRG.19792.1_2 - 0.028 13.8 0.1 2.3 7.5 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein ANTAR PF03861.12 MSTRG.19792.1_2 - 0.031 14.0 0.0 0.078 12.7 0.0 1.7 1 0 0 1 1 1 0 ANTAR domain CDP-OH_P_transf PF01066.19 MSTRG.4767.1_1 - 5.6e-17 62.1 0.3 5.6e-17 62.1 0.3 2.8 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase hemP PF10636.7 MSTRG.4767.1_3 - 0.043 13.5 0.1 0.17 11.6 0.1 2.0 1 0 0 1 1 1 0 Hemin uptake protein hemP RRM_1 PF00076.20 MSTRG.4179.1_2 - 3.3e-18 65.1 0.0 1.6e-17 63.0 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPR_2 PF07719.15 MSTRG.4179.1_2 - 8e-15 53.6 0.1 8.7e-05 22.2 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.4179.1_2 - 1.3e-10 40.5 0.2 0.011 15.3 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.4179.1_2 - 1.8e-07 31.5 0.2 0.0098 16.3 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.4179.1_2 - 7e-07 28.9 1.6 0.00047 20.0 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat RRM_occluded PF16842.3 MSTRG.4179.1_2 - 2.5e-05 23.9 0.0 4.7e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_5 PF13893.4 MSTRG.4179.1_2 - 6.7e-05 22.4 0.0 0.00016 21.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPR_16 PF13432.4 MSTRG.4179.1_2 - 7.2e-05 23.3 0.0 0.77 10.4 0.0 2.9 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_9 PF13371.4 MSTRG.4179.1_2 - 0.0011 18.9 0.1 0.1 12.6 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.4179.1_2 - 0.0023 18.1 0.1 0.021 15.1 0.2 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.4179.1_2 - 0.0024 18.4 0.3 5.2 8.0 0.0 3.6 2 1 2 4 4 3 1 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.4179.1_2 - 0.0026 17.9 0.8 11 6.3 0.9 3.4 2 1 0 2 2 2 0 Tetratricopeptide repeat zf-CCCH_3 PF15663.3 MSTRG.4179.1_2 - 0.0032 17.6 0.7 0.009 16.1 0.7 1.7 1 0 0 1 1 1 1 Zinc-finger containing family zf-CCCH PF00642.22 MSTRG.4179.1_2 - 0.017 14.9 4.5 0.042 13.6 4.5 1.7 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_3 PF08777.9 MSTRG.4179.1_2 - 0.035 14.0 0.0 0.035 14.0 0.0 2.6 3 0 0 3 3 2 0 RNA binding motif TPR_11 PF13414.4 MSTRG.4179.1_2 - 0.037 13.6 0.3 0.39 10.3 0.0 2.5 1 1 0 2 2 2 0 TPR repeat TPR_7 PF13176.4 MSTRG.4179.1_2 - 0.042 13.8 0.1 7.4 6.7 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat PNISR PF15996.3 MSTRG.4179.1_2 - 1 9.4 23.7 1.8 8.6 23.7 1.4 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Hamartin PF04388.10 MSTRG.4179.1_2 - 1.1 7.6 12.8 1.6 7.2 12.8 1.1 1 0 0 1 1 1 0 Hamartin protein zf-CCCH_2 PF14608.4 MSTRG.4179.1_2 - 2.3 8.7 5.3 11 6.5 5.3 2.3 1 1 0 1 1 1 0 RNA-binding, Nab2-type zinc finger SH2 PF00017.22 MSTRG.16026.1_2 - 1.4e-12 47.4 0.1 1.7e-12 47.1 0.1 1.1 1 0 0 1 1 1 1 SH2 domain Ig_2 PF13895.4 MSTRG.6292.2_1 - 4e-07 30.2 0.0 5.2e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.6292.2_1 - 1.9e-05 25.0 0.0 2.9e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 MSTRG.6292.2_1 - 0.0037 17.2 0.0 0.0058 16.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.15 MSTRG.6292.2_1 - 0.0094 16.0 0.2 4.3 7.4 0.0 2.1 1 1 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.23 MSTRG.6292.2_1 - 0.015 15.3 0.1 0.059 13.4 0.1 1.8 1 1 0 1 1 1 0 Immunoglobulin domain Phytoreo_Pns PF05451.9 MSTRG.20321.1_1 - 0.2 10.6 0.0 0.28 10.2 0.0 1.1 1 0 0 1 1 1 0 Phytoreovirus nonstructural protein Pns10/11 AT_hook PF02178.17 MSTRG.20321.1_2 - 1 9.3 33.4 2.3 8.2 2.0 3.5 3 0 0 3 3 3 0 AT hook motif MENTAL PF10457.7 MSTRG.5441.2_2 - 2.3 7.9 8.9 7.7 6.2 0.8 2.1 1 1 1 2 2 2 0 Cholesterol-capturing domain AC_N PF16214.3 MSTRG.5441.2_2 - 6.4 5.7 8.7 11 4.9 8.7 1.3 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region AdoMetDC_leader PF08132.9 MSTRG.14074.1_1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 S-adenosyl-l-methionine decarboxylase leader peptide zf-met PF12874.5 MSTRG.14074.1_3 - 3.8e-23 81.0 15.3 1.7e-08 34.5 0.6 3.9 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.14074.1_3 - 2.8e-16 59.2 12.0 2.3e-05 24.4 1.0 3.6 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 MSTRG.14074.1_3 - 4.1e-07 30.1 3.9 0.33 11.2 0.0 3.3 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) AKAP95 PF04988.10 MSTRG.14074.1_3 - 1e-05 25.7 2.7 0.23 11.5 0.1 3.3 3 0 0 3 3 3 3 A-kinase anchoring protein 95 (AKAP95) zf-U1 PF06220.10 MSTRG.14074.1_3 - 0.00019 21.0 4.1 0.11 12.1 0.0 3.5 3 0 0 3 3 3 2 U1 zinc finger zf-C2H2 PF00096.24 MSTRG.14074.1_3 - 0.019 15.2 9.7 4.4 7.8 0.2 3.9 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-DBF PF07535.10 MSTRG.14074.1_3 - 0.027 14.4 7.4 0.086 12.8 0.3 3.3 3 0 0 3 3 3 0 DBF zinc finger zf-C2H2_9 PF16293.3 MSTRG.14074.1_3 - 0.19 11.5 3.3 21 4.9 0.1 3.3 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) zf-C2H2_4 PF13894.4 MSTRG.14074.1_3 - 0.24 12.2 12.1 1.3 9.9 0.3 4.9 5 0 0 5 5 5 0 C2H2-type zinc finger RRM_1 PF00076.20 MSTRG.24557.1_3 - 7.5e-08 32.0 0.0 1.4e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ubiquitin PF00240.21 MSTRG.181.1_2 - 2.4e-06 27.1 0.1 3.8e-06 26.4 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 MSTRG.181.1_2 - 0.038 13.7 0.1 0.058 13.1 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like PRA1 PF03208.17 MSTRG.23308.2_3 - 6.2e-27 93.8 0.7 8.1e-27 93.5 0.7 1.1 1 0 0 1 1 1 1 PRA1 family protein HHV6-IE PF03753.11 MSTRG.10543.1_1 - 0.044 11.3 0.3 0.051 11.1 0.3 1.0 1 0 0 1 1 1 0 Human herpesvirus 6 immediate early protein AAA_12 PF13087.4 MSTRG.21611.1_1 - 2.1e-43 148.1 0.0 3.3e-43 147.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.4 MSTRG.21611.1_1 - 4e-30 105.3 0.0 9.3e-15 54.9 0.0 2.3 1 1 1 2 2 2 2 AAA domain S1-like PF14444.4 MSTRG.21611.1_1 - 5.3e-18 64.7 0.1 3.1e-06 27.0 0.1 3.5 3 0 0 3 3 3 3 S1-like AAA_30 PF13604.4 MSTRG.21611.1_1 - 2.1e-13 50.3 0.0 3.7e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.4 MSTRG.21611.1_1 - 6.6e-07 29.6 0.0 1.3e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.13 MSTRG.21611.1_1 - 1.2e-06 28.5 0.0 2.1e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.19 MSTRG.21611.1_1 - 0.0039 16.6 0.0 0.14 11.5 0.0 2.7 3 0 0 3 3 3 1 UvrD/REP helicase N-terminal domain AAA_22 PF13401.4 MSTRG.21611.1_1 - 0.075 13.2 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.27 MSTRG.21611.1_1 - 0.17 12.2 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Phosphodiest PF01663.20 MSTRG.19495.1_1 - 1.2e-31 110.5 1.0 1.3e-31 110.3 1.0 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.21 MSTRG.19495.1_1 - 7.5e-06 25.4 0.0 9e-06 25.2 0.0 1.1 1 0 0 1 1 1 1 Sulfatase PAP2_3 PF14378.4 MSTRG.19495.1_1 - 0.022 14.3 0.5 0.024 14.2 0.5 1.3 1 1 0 1 1 1 0 PAP2 superfamily IL17R_fnIII_D1 PF16556.3 MSTRG.5150.1_2 - 3.6e-54 182.4 0.1 7.1e-54 181.5 0.1 1.5 1 0 0 1 1 1 1 Interleukin-17 receptor, fibronectin-III-like domain 1 SEFIR PF08357.9 MSTRG.5150.1_2 - 1.2e-32 113.1 0.0 2.5e-32 112.1 0.0 1.6 1 0 0 1 1 1 1 SEFIR domain IL17R_fnIII_D2 PF16578.3 MSTRG.5150.1_2 - 3.7e-12 46.6 1.6 1e-11 45.2 1.6 1.8 1 0 0 1 1 1 1 Interleukin 17 receptor D ENOD93 PF03386.12 MSTRG.5150.1_2 - 0.082 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Early nodulin 93 ENOD93 protein A_deamin PF02137.16 MSTRG.4108.1_3 - 1.5e-12 47.5 0.0 1.6e-12 47.4 0.0 1.0 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain A2M_comp PF07678.12 MSTRG.18931.1_1 - 2.8e-52 177.5 0.5 3.2e-50 170.8 0.5 2.3 1 1 0 1 1 1 1 A-macroglobulin complement component A2M PF00207.20 MSTRG.18931.1_1 - 2.2e-31 107.4 0.0 1.2e-30 105.0 0.0 2.5 1 0 0 1 1 1 1 Alpha-2-macroglobulin family A2M_recep PF07677.12 MSTRG.18931.1_1 - 2.9e-27 95.2 0.1 1.5e-26 92.9 0.0 2.4 2 0 0 2 2 2 1 A-macroglobulin receptor NTR PF01759.19 MSTRG.18931.1_1 - 5.2e-26 90.4 0.6 3.8e-25 87.6 0.0 2.7 3 0 0 3 3 3 1 UNC-6/NTR/C345C module A2M_N_2 PF07703.12 MSTRG.18931.1_1 - 6.4e-26 91.2 0.0 1e-24 87.3 0.0 2.9 2 0 0 2 2 2 1 Alpha-2-macroglobulin family N-terminal region Thiol-ester_cl PF10569.7 MSTRG.18931.1_1 - 3.2e-12 45.8 1.1 6.6e-12 44.8 1.1 1.6 1 0 0 1 1 1 1 Alpha-macro-globulin thiol-ester bond-forming region A2M_N PF01835.17 MSTRG.18931.1_1 - 9.8e-12 45.0 0.0 2.8e-11 43.6 0.0 1.9 1 0 0 1 1 1 1 MG2 domain ANATO PF01821.16 MSTRG.18931.1_1 - 4.5e-10 40.1 3.2 1.3e-09 38.6 3.2 1.9 1 0 0 1 1 1 1 Anaphylotoxin-like domain AAA_8 PF12780.5 MSTRG.19125.1_1 - 2.8e-37 128.3 0.0 4e-37 127.7 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_5 PF07728.12 MSTRG.19125.1_1 - 0.01 15.7 0.0 0.016 15.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.5 MSTRG.19125.1_3 - 1.3e-42 145.9 0.0 1.6e-42 145.5 0.0 1.1 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 Chorein_N PF12624.5 MSTRG.24623.1_3 - 7.9e-26 90.3 0.1 2.2e-25 88.9 0.1 1.8 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.3 MSTRG.24623.1_3 - 2.3e-06 27.5 2.9 2.2e-05 24.3 2.7 2.5 2 1 0 2 2 2 1 Vacuolar sorting-associated protein 13, N-terminal MFS_1 PF07690.14 MSTRG.18303.2_1 - 1e-61 208.7 31.0 3.2e-61 207.1 24.8 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Translin PF01997.14 MSTRG.1165.1_3 - 5.6e-54 183.1 0.1 7e-54 182.8 0.1 1.1 1 0 0 1 1 1 1 Translin family Ldh_1_N PF00056.21 MSTRG.28391.1_3 - 0.0015 18.5 0.1 0.002 18.1 0.1 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain ECSIT PF06239.9 MSTRG.25955.2_3 - 1.8e-97 324.8 1.0 2.7e-97 324.2 1.0 1.2 1 0 0 1 1 1 1 Evolutionarily conserved signalling intermediate in Toll pathway ECSIT_C PF14784.4 MSTRG.25955.2_3 - 1.3e-43 148.3 0.0 2.2e-43 147.5 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of the ECSIT protein PPR_2 PF13041.4 MSTRG.25955.2_3 - 0.13 12.4 0.0 1.8 8.7 0.0 2.3 2 0 0 2 2 2 0 PPR repeat family APH PF01636.21 MSTRG.13588.1_1 - 8.4e-18 65.0 0.0 1.3e-17 64.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.18 MSTRG.13588.1_1 - 0.0016 17.7 0.1 0.0024 17.1 0.1 1.1 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.9 MSTRG.13588.1_1 - 0.017 13.9 0.0 0.025 13.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) APH PF01636.21 MSTRG.13588.1_2 - 0.14 11.9 0.0 0.2 11.4 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family Nebulin PF00880.16 MSTRG.1479.6_1 - 0 1709.5 586.9 2.6e-10 39.9 2.0 141.4 147 0 0 147 147 147 112 Nebulin repeat Peptidase_M24 PF00557.22 MSTRG.1479.6_1 - 2.9e-14 53.1 3.4 0.28 10.7 0.0 9.5 9 0 0 9 9 9 5 Metallopeptidase family M24 SH3_1 PF00018.26 MSTRG.1479.6_1 - 3.1e-12 45.7 0.0 1.5e-11 43.6 0.0 2.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.1479.6_1 - 3.5e-12 45.9 0.0 7.5e-12 44.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.1479.6_1 - 1e-05 25.0 0.0 8e-05 22.1 0.0 2.6 2 0 0 2 2 2 1 Variant SH3 domain Toprim_2 PF13155.4 MSTRG.1479.6_1 - 0.44 10.9 7.7 69 3.9 0.0 6.2 6 0 0 6 6 6 0 Toprim-like Retrotran_gag_3 PF14244.4 MSTRG.22267.1_1 - 0.11 12.2 1.0 0.25 11.1 1.0 1.6 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type LRAT PF04970.11 MSTRG.27523.1_3 - 1.3e-39 135.3 0.0 1.8e-39 134.8 0.0 1.2 1 0 0 1 1 1 1 Lecithin retinol acyltransferase BUD22 PF09073.8 MSTRG.10813.1_1 - 8.7e-12 45.0 40.4 2.3e-11 43.6 6.6 4.4 3 1 1 4 4 4 2 BUD22 SWIM PF04434.15 MSTRG.22851.1_1 - 0.00019 20.9 9.4 0.0004 19.8 9.4 1.5 1 0 0 1 1 1 1 SWIM zinc finger Aminotran_1_2 PF00155.19 MSTRG.12841.1_1 - 2.6e-33 115.6 0.0 3.3e-33 115.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Methyltransf_2 PF00891.16 MSTRG.29200.1_3 - 3.6e-11 42.6 0.0 4.2e-11 42.4 0.0 1.0 1 0 0 1 1 1 1 O-methyltransferase EzrA PF06160.10 MSTRG.14455.1_2 - 0.00028 19.1 4.1 0.00028 19.1 4.1 2.3 2 0 0 2 2 2 1 Septation ring formation regulator, EzrA IncA PF04156.12 MSTRG.14455.1_2 - 0.00039 20.1 1.8 0.00039 20.1 1.8 3.9 3 1 1 4 4 2 1 IncA protein HALZ PF02183.16 MSTRG.14455.1_2 - 0.017 15.2 0.3 0.017 15.2 0.3 3.6 4 0 0 4 4 3 0 Homeobox associated leucine zipper Nsp1_C PF05064.11 MSTRG.14455.1_2 - 0.039 13.6 1.5 11 5.8 0.0 2.5 2 0 0 2 2 2 0 Nsp1-like C-terminal region APG6 PF04111.10 MSTRG.14455.1_2 - 0.041 13.2 0.3 0.041 13.2 0.3 3.1 2 1 1 3 3 3 0 Autophagy protein Apg6 Fez1 PF06818.13 MSTRG.14455.1_2 - 0.071 13.4 36.9 0.15 12.4 4.5 3.3 2 1 1 3 3 3 0 Fez1 ZapB PF06005.10 MSTRG.14455.1_2 - 0.098 13.0 0.2 0.098 13.0 0.2 4.7 4 1 1 5 5 3 0 Cell division protein ZapB FlxA PF14282.4 MSTRG.14455.1_2 - 0.17 11.8 12.2 1.7 8.5 4.9 4.0 3 1 1 4 4 4 0 FlxA-like protein TBPIP PF07106.11 MSTRG.14455.1_2 - 0.31 10.7 15.9 1.8 8.1 1.2 3.4 3 1 0 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) HMMR_N PF15905.3 MSTRG.14455.1_2 - 0.31 10.3 19.5 0.098 12.0 9.8 2.4 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal KASH_CCD PF14662.4 MSTRG.14455.1_2 - 0.36 10.5 25.1 0.26 11.0 4.2 3.2 3 0 0 3 3 3 0 Coiled-coil region of CCDC155 or KASH Leu_zip PF15294.4 MSTRG.14455.1_2 - 0.38 10.1 15.9 2.1 7.6 1.0 3.3 3 0 0 3 3 3 0 Leucine zipper DUF972 PF06156.11 MSTRG.14455.1_2 - 0.55 10.7 16.1 8.7 6.9 2.0 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF972) Laminin_II PF06009.10 MSTRG.14455.1_2 - 0.93 9.4 6.0 5.7 6.8 0.0 3.3 2 1 1 3 3 3 0 Laminin Domain II EMP24_GP25L PF01105.22 MSTRG.14455.1_2 - 1.4 8.7 4.6 22 4.8 0.1 3.0 3 0 0 3 3 3 0 emp24/gp25L/p24 family/GOLD KLRAQ PF10205.7 MSTRG.14455.1_2 - 1.7 8.8 10.0 0.67 10.1 0.5 3.8 3 1 1 4 4 4 0 Predicted coiled-coil domain-containing protein Spc7 PF08317.9 MSTRG.14455.1_2 - 3.4 6.3 28.7 0.17 10.6 0.5 3.1 2 1 1 3 3 3 0 Spc7 kinetochore protein Jnk-SapK_ap_N PF09744.7 MSTRG.14455.1_2 - 7.8 6.6 43.9 0.74 9.9 12.5 3.9 2 1 2 4 4 4 0 JNK_SAPK-associated protein-1 AAA_23 PF13476.4 MSTRG.14455.1_2 - 8.5 6.7 13.5 11 6.4 6.2 2.2 2 0 0 2 2 2 0 AAA domain DUF3972 PF13118.4 MSTRG.14455.1_2 - 9.1 6.6 6.6 0.95 9.8 0.1 2.3 3 0 0 3 3 2 0 Protein of unknown function (DUF3972) NTF2 PF02136.18 MSTRG.8064.1_3 - 3.6e-31 108.1 0.2 5.6e-31 107.4 0.2 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.20 MSTRG.8064.1_3 - 3.3e-12 45.9 0.0 6.4e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.8064.1_3 - 0.0035 17.3 0.0 0.014 15.4 0.0 2.0 1 1 0 1 1 1 1 RNA recognition motif BRE PF06113.10 MSTRG.1674.1_1 - 1.2e-130 434.9 0.0 1.6e-130 434.5 0.0 1.1 1 0 0 1 1 1 1 Brain and reproductive organ-expressed protein (BRE) UQ_con PF00179.24 MSTRG.1674.1_1 - 0.56 9.7 3.1 8.9 5.8 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-conjugating enzyme Sema PF01403.17 MSTRG.9352.1_1 - 1.6e-157 524.5 0.0 3.5e-157 523.4 0.0 1.5 2 0 0 2 2 2 1 Sema domain ig PF00047.23 MSTRG.9352.1_1 - 0.00019 21.4 0.0 0.0004 20.4 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.9352.1_1 - 0.00027 21.3 0.0 0.00073 20.0 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain PSI PF01437.23 MSTRG.9352.1_1 - 0.0028 18.0 6.9 0.0028 18.0 6.9 3.2 3 0 0 3 3 3 1 Plexin repeat I-set PF07679.14 MSTRG.9352.1_1 - 0.0054 16.6 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.15 MSTRG.9352.1_1 - 0.0057 16.7 0.1 0.11 12.6 0.1 2.4 1 1 0 1 1 1 1 Immunoglobulin V-set domain Nrf1_DNA-bind PF10491.7 MSTRG.11695.1_1 - 2.9e-113 376.6 0.0 4.1e-113 376.1 0.0 1.2 1 0 0 1 1 1 1 NLS-binding and DNA-binding and dimerisation domains of Nrf1 Nrf1_activ_bdg PF10492.7 MSTRG.11695.1_1 - 0.0036 17.8 5.2 0.0036 17.8 5.2 4.9 3 2 1 4 4 4 1 Nrf1 activator activation site binding domain RRM_1 PF00076.20 MSTRG.6795.5_1 - 5.7e-16 58.0 0.0 8.7e-16 57.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Apt1 PF10351.7 MSTRG.6795.5_1 - 0.63 8.7 13.4 0.86 8.3 13.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.7 MSTRG.6795.5_1 - 3.4 6.0 8.9 4.2 5.7 8.9 1.1 1 0 0 1 1 1 0 Transmembrane protein Spectrin PF00435.19 MSTRG.324.2_1 - 4.8e-55 184.4 35.0 1.2e-19 70.6 2.9 3.7 4 0 0 4 4 4 3 Spectrin repeat EFhand_Ca_insen PF08726.8 MSTRG.324.2_1 - 1.2e-25 89.2 0.3 4.1e-25 87.5 0.3 2.0 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_1 PF00036.30 MSTRG.324.2_1 - 5.4e-13 47.4 0.3 1.6e-06 27.1 0.1 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.4 MSTRG.324.2_1 - 1.3e-11 44.7 1.2 1.7e-09 37.8 0.0 2.9 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.324.2_1 - 2.8e-10 39.2 0.1 9.8e-05 21.9 0.1 3.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.4 MSTRG.324.2_1 - 4.6e-10 39.0 0.0 0.0076 15.9 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.324.2_1 - 2.9e-05 23.3 0.0 0.41 10.1 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_10 PF14788.4 MSTRG.324.2_1 - 0.07 12.9 1.4 0.12 12.1 0.4 2.0 2 0 0 2 2 2 0 EF hand EF-hand_9 PF14658.4 MSTRG.324.2_1 - 0.11 12.7 0.0 0.31 11.3 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain SPARC_Ca_bdg PF10591.7 MSTRG.324.2_1 - 0.23 11.7 11.0 8.7 6.6 8.4 4.3 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region YqzE PF14038.4 MSTRG.7404.1_1 - 4.9 7.1 11.5 2.4 8.1 3.1 3.1 2 1 1 3 3 3 0 YqzE-like protein Collagen PF01391.16 MSTRG.7404.1_2 - 2.8e-08 33.3 28.9 2.8e-08 33.3 28.9 2.0 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) Nbas_N PF15492.4 MSTRG.8310.1_1 - 2.9e-168 558.2 0.1 5e-168 557.4 0.1 1.4 1 0 0 1 1 1 1 Neuroblastoma-amplified sequence, N terminal Sec39 PF08314.9 MSTRG.8310.1_1 - 3.8e-29 101.6 0.0 9.2e-27 93.7 0.0 2.3 1 1 0 1 1 1 1 Secretory pathway protein Sec39 ANAPC4_WD40 PF12894.5 MSTRG.8310.1_1 - 0.00037 20.6 0.0 1.3 9.3 0.0 3.1 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_M16 PF00675.18 MSTRG.15197.4_1 - 3.5e-55 185.9 0.1 5e-55 185.4 0.1 1.2 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.19 MSTRG.15197.4_1 - 1.7e-35 122.6 0.0 8e-35 120.4 0.0 1.9 2 0 0 2 2 2 1 Peptidase M16 inactive domain SSF PF00474.15 MSTRG.4667.1_2 - 1.2e-28 100.0 20.4 1.9e-28 99.3 20.4 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family DUF938 PF06080.10 MSTRG.4667.1_2 - 0.059 13.0 0.1 7.5 6.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF938) SSF PF00474.15 MSTRG.4667.1_3 - 1.3e-30 106.4 17.5 2e-30 105.8 17.5 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family DUF2316 PF10078.7 MSTRG.18246.1_1 - 0.17 12.1 0.0 0.25 11.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2316) RRM_1 PF00076.20 MSTRG.25607.1_3 - 9.2e-09 34.9 0.0 1.5e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PWI PF01480.15 MSTRG.25607.1_3 - 1.7e-06 28.1 0.2 0.00025 21.1 0.0 2.4 2 0 0 2 2 2 2 PWI domain Y_phosphatase PF00102.25 MSTRG.17926.6_1 - 5.1e-147 487.6 0.0 3.3e-84 282.0 0.0 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.19 MSTRG.17926.6_1 - 1.9e-12 47.2 0.1 7.9e-09 35.6 0.0 3.9 4 0 0 4 4 4 2 Fibronectin type III domain DSPc PF00782.18 MSTRG.17926.6_1 - 1.7e-07 31.0 0.1 0.0098 15.6 0.1 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 MSTRG.17926.6_1 - 0.00047 20.1 0.2 0.024 14.5 0.0 2.5 2 0 0 2 2 2 1 Tyrosine phosphatase family PTPlike_phytase PF14566.4 MSTRG.17926.6_1 - 0.003 17.6 0.0 0.022 14.8 0.0 2.4 2 0 0 2 2 2 1 Inositol hexakisphosphate EphA2_TM PF14575.4 MSTRG.17926.6_1 - 0.31 11.8 1.4 0.48 11.2 0.1 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TPR_1 PF00515.26 MSTRG.5292.1_2 - 8.4e-44 145.5 5.2 1.8e-09 36.9 0.1 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.5292.1_2 - 4.3e-33 110.6 10.3 3e-07 29.9 0.1 9.9 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.5292.1_2 - 3.6e-29 98.4 5.0 2.6e-06 27.1 0.1 9.7 9 0 0 9 9 9 5 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.5292.1_2 - 3.2e-28 97.6 20.0 2.2e-21 75.7 3.5 5.0 3 1 3 6 6 6 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.4 MSTRG.5292.1_2 - 5.5e-23 80.9 8.3 4.7e-05 23.5 0.0 7.6 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.5292.1_2 - 3.1e-20 72.4 0.0 3.8e-05 24.2 0.0 6.8 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.5292.1_2 - 4.4e-19 67.8 8.1 0.00029 20.3 0.0 7.0 4 1 4 8 8 8 5 TPR repeat TPR_14 PF13428.4 MSTRG.5292.1_2 - 3.7e-18 64.5 0.4 0.044 14.5 0.0 8.7 5 2 4 9 9 9 3 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.5292.1_2 - 6.1e-18 65.0 7.4 0.098 13.0 0.2 7.8 5 2 3 8 8 7 5 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.5292.1_2 - 2.8e-15 55.4 6.1 0.46 10.9 0.0 8.5 9 0 0 9 9 7 5 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.5292.1_2 - 2.2e-11 43.5 9.1 0.92 10.1 0.8 8.9 10 0 0 10 10 8 2 Tetratricopeptide repeat TPR_9 PF13371.4 MSTRG.5292.1_2 - 2.9e-09 36.8 0.0 0.13 12.3 0.0 4.8 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.5292.1_2 - 1.7e-08 33.7 0.3 3.4 7.8 0.0 7.4 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_15 PF13429.4 MSTRG.5292.1_2 - 7.6e-05 21.9 0.1 1.2 8.2 0.0 4.5 2 2 3 5 5 5 2 Tetratricopeptide repeat ChAPs PF09295.8 MSTRG.5292.1_2 - 0.00021 20.3 0.3 0.61 8.9 0.0 2.8 2 1 0 3 3 3 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_10 PF13374.4 MSTRG.5292.1_2 - 0.00048 19.8 6.2 2.6 7.9 0.0 6.0 7 0 0 7 7 7 2 Tetratricopeptide repeat DUF5113 PF17140.2 MSTRG.5292.1_2 - 0.024 14.3 1.2 0.12 12.0 0.3 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF5113) TPR_20 PF14561.4 MSTRG.5292.1_2 - 0.063 13.5 0.6 0.45 10.8 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_21 PF09976.7 MSTRG.5292.1_2 - 0.11 12.1 0.0 0.55 9.8 0.0 2.1 1 1 0 1 1 1 0 Tetratricopeptide repeat-like domain SRP_TPR_like PF17004.3 MSTRG.5292.1_2 - 0.12 12.3 5.8 1.9 8.4 0.4 3.1 3 1 0 3 3 3 0 Putative TPR-like repeat RNA_pol_Rpb8 PF03870.13 MSTRG.10511.1_2 - 5.2e-25 88.1 0.0 6.1e-25 87.9 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb8 Nexin_C PF08628.10 MSTRG.16397.2_1 - 3.5e-16 59.7 0.0 6.2e-16 58.9 0.0 1.4 1 0 0 1 1 1 1 Sorting nexin C terminal PXA PF02194.13 MSTRG.16397.2_2 - 4.2e-32 111.2 0.1 6.9e-32 110.5 0.1 1.4 1 0 0 1 1 1 1 PXA domain PX PF00787.22 MSTRG.16397.2_2 - 2e-18 66.3 0.4 5.1e-18 65.0 0.4 1.7 1 0 0 1 1 1 1 PX domain RGS PF00615.17 MSTRG.16397.2_2 - 7.5e-12 45.4 0.0 1.3e-11 44.7 0.0 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain APC_u13 PF16634.3 MSTRG.16397.2_3 - 0.078 12.8 0.1 0.18 11.6 0.1 1.6 1 0 0 1 1 1 0 Unstructured region on APC between APC_crr and SAMP NAPRTase PF04095.14 MSTRG.6029.1_2 - 7.6e-24 84.5 0.0 1e-23 84.1 0.0 1.2 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family Aa_trans PF01490.16 MSTRG.14191.4_3 - 1.6e-91 307.0 38.5 4.1e-91 305.6 38.5 1.7 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein TIG PF01833.22 MSTRG.9937.1_1 - 1.2e-07 31.6 0.4 1.2e-07 31.6 0.4 1.6 2 0 0 2 2 2 1 IPT/TIG domain Dus PF01207.15 MSTRG.3458.1_1 - 8.9e-59 199.0 0.0 2.9e-58 197.3 0.0 1.8 3 0 0 3 3 3 1 Dihydrouridine synthase (Dus) zf-CCCH PF00642.22 MSTRG.3458.1_1 - 1.3e-06 28.1 11.3 0.00089 19.0 1.0 2.7 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.4 MSTRG.3458.1_1 - 0.15 12.5 9.1 0.42 11.0 2.7 2.7 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger PEP_mutase PF13714.4 MSTRG.3458.1_1 - 0.16 11.2 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate phosphomutase Torus PF16131.3 MSTRG.3458.1_1 - 4 8.1 5.7 3.2 8.4 2.0 2.3 1 1 1 2 2 2 0 Torus domain Hormone_recep PF00104.28 MSTRG.23730.3_1 - 9e-41 139.6 0.0 1.4e-40 138.9 0.0 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Nuc_recep-AF1 PF11825.6 MSTRG.23730.3_1 - 3.7e-40 136.4 22.6 6.2e-40 135.7 22.6 1.3 1 0 0 1 1 1 1 Nuclear/hormone receptor activator site AF-1 zf-C4 PF00105.16 MSTRG.23730.3_1 - 1e-31 109.1 16.5 2.4e-31 107.9 16.5 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Spectrin PF00435.19 MSTRG.7861.4_2 - 2.8e-193 628.7 244.0 2.5e-13 50.3 4.1 27.9 27 1 0 27 27 27 24 Spectrin repeat GAS2 PF02187.15 MSTRG.7861.4_2 - 2.8e-33 113.7 0.4 8.5e-33 112.1 0.4 1.9 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain EF-hand_6 PF13405.4 MSTRG.7861.4_2 - 4.3e-11 41.7 1.6 0.00032 20.3 0.4 3.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.30 MSTRG.7861.4_2 - 5.7e-11 41.0 6.3 6.3e-05 22.1 0.7 3.3 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.4 MSTRG.7861.4_2 - 1.3e-10 41.5 0.9 6.2e-10 39.3 0.9 2.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.4 MSTRG.7861.4_2 - 7.7e-09 35.1 0.6 8.8e-08 31.7 0.2 2.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.7861.4_2 - 2.9e-08 32.7 4.1 1.9e-05 23.9 1.4 2.9 2 0 0 2 2 2 2 EF hand PhageMin_Tail PF10145.7 MSTRG.7861.4_2 - 0.09 12.5 4.8 2.2 7.9 0.3 4.6 3 0 0 3 3 3 0 Phage-related minor tail protein NleF_casp_inhib PF16809.3 MSTRG.7861.4_2 - 0.1 12.4 5.0 0.14 12.0 0.8 3.5 4 0 0 4 4 4 0 NleF caspase inhibitor Shugoshin_N PF07558.9 MSTRG.7861.4_2 - 0.1 12.3 5.3 0.062 13.0 1.0 2.7 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region Mce4_CUP1 PF11887.6 MSTRG.7861.4_2 - 2.2 7.6 7.2 6.9 5.9 0.5 4.6 3 0 0 3 3 3 0 Cholesterol uptake porter CUP1 of Mce4, putative SUIM_assoc PF16619.3 MSTRG.7861.4_2 - 3.1 7.8 10.6 14 5.7 7.0 3.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Myc_N PF01056.16 MSTRG.17734.2_2 - 2.3e-40 139.4 15.0 3e-37 129.1 1.7 3.4 1 1 2 3 3 3 2 Myc amino-terminal region HLH PF00010.24 MSTRG.17734.2_2 - 1.2e-14 53.8 1.5 3.9e-14 52.2 1.5 1.9 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain CDC45 PF02724.12 MSTRG.17734.2_2 - 0.09 10.9 13.6 0.16 10.1 13.6 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF3287 PF11690.6 MSTRG.17734.2_2 - 0.44 10.1 6.1 0.49 10.0 4.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3287) DUF4611 PF15387.4 MSTRG.17734.2_2 - 1.9 8.6 11.2 3 8.0 5.9 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Tub_N PF16322.3 MSTRG.17734.2_2 - 8.4 6.5 21.7 0.53 10.4 16.1 1.8 1 1 1 2 2 2 0 Tubby N-terminal Homeobox PF00046.27 MSTRG.17506.2_1 - 1.8e-21 75.6 7.0 3e-21 74.8 7.0 1.4 1 0 0 1 1 1 1 Homeobox domain QLQ PF08880.9 MSTRG.17506.2_1 - 0.004 16.7 0.5 0.011 15.4 0.4 1.8 2 0 0 2 2 2 1 QLQ Radial_spoke PF04712.10 MSTRG.17506.2_1 - 0.021 13.7 1.0 0.028 13.2 1.0 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein NOA36 PF06524.10 MSTRG.17506.2_1 - 0.046 13.0 1.8 0.075 12.3 1.8 1.2 1 0 0 1 1 1 0 NOA36 protein DUF4746 PF15928.3 MSTRG.17506.2_1 - 0.93 8.7 5.8 1.3 8.3 5.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF2125 PF09898.7 MSTRG.11207.1_2 - 0.12 11.9 0.9 0.14 11.7 0.9 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2125) 4_1_CTD PF05902.11 MSTRG.2804.6_1 - 1.1e-33 115.5 4.0 1.1e-33 115.5 4.0 2.8 3 1 0 3 3 3 1 4.1 protein C-terminal domain (CTD) Red1 PF07964.9 MSTRG.2804.6_1 - 0.12 10.5 11.5 0.13 10.3 11.5 1.1 1 0 0 1 1 1 0 Rec10 / Red1 Secretogranin_V PF05281.9 MSTRG.7855.1_2 - 9.2e-10 38.4 0.5 5e-08 32.7 0.1 2.1 2 0 0 2 2 2 2 Neuroendocrine protein 7B2 precursor (Secretogranin V) Y_phosphatase PF00102.25 MSTRG.6957.1_3 - 1.8e-75 253.4 2.1 2.5e-75 253.0 2.1 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase SH2 PF00017.22 MSTRG.6957.1_3 - 1.3e-44 150.0 0.0 7.8e-21 73.8 0.0 2.7 2 0 0 2 2 2 2 SH2 domain DSPc PF00782.18 MSTRG.6957.1_3 - 0.002 17.8 0.0 0.0053 16.4 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 MSTRG.6957.1_3 - 0.0089 15.9 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.4 MSTRG.6957.1_3 - 0.012 15.6 0.0 0.032 14.2 0.0 1.7 1 0 0 1 1 1 0 Inositol hexakisphosphate Lipoprotein_X PF03305.11 MSTRG.6957.1_3 - 0.046 13.4 0.3 0.15 11.7 0.1 1.8 2 0 0 2 2 2 0 Mycoplasma MG185/MG260 protein DUF4200 PF13863.4 MSTRG.5646.1_1 - 9.3e-06 25.9 18.7 9.3e-06 25.9 18.7 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4200) HD_4 PF13328.4 MSTRG.5646.1_1 - 0.029 14.0 2.8 0.057 13.0 2.8 1.5 1 0 0 1 1 1 0 HD domain NUDIX PF00293.26 MSTRG.25330.2_3 - 5.8e-23 81.2 0.0 8.4e-23 80.7 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain GHL10 PF02638.13 MSTRG.25330.2_3 - 0.053 12.5 0.1 0.082 11.8 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase-like 10 zf-CCCH PF00642.22 MSTRG.12452.7_2 - 3.7e-08 32.9 19.1 0.001 18.8 0.9 4.7 4 0 0 4 4 4 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.3 MSTRG.12452.7_2 - 0.0095 16.1 0.9 0.0095 16.1 0.9 3.5 4 0 0 4 4 4 2 Zinc-finger containing family zf-CCCH_2 PF14608.4 MSTRG.12452.7_2 - 0.011 16.0 29.1 0.88 10.0 1.4 5.6 5 0 0 5 5 5 0 RNA-binding, Nab2-type zinc finger zf-C2H2 PF00096.24 MSTRG.20001.2_1 - 0.0019 18.4 3.1 0.0047 17.2 3.1 1.7 1 0 0 1 1 1 1 Zinc finger, C2H2 type E1-E2_ATPase PF00122.18 MSTRG.23306.3_2 - 6.5e-58 195.5 2.4 1.2e-57 194.6 2.4 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 MSTRG.23306.3_2 - 3.5e-42 144.0 0.1 3.5e-42 144.0 0.1 2.7 4 0 0 4 4 4 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 MSTRG.23306.3_2 - 1.9e-24 85.4 0.0 4.3e-24 84.3 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.24 MSTRG.23306.3_2 - 1e-19 69.8 0.1 4e-19 67.9 0.0 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.24 MSTRG.23306.3_2 - 9.3e-19 68.4 0.1 1e-09 38.9 0.0 2.8 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.10 MSTRG.23306.3_2 - 2.2e-05 24.2 1.0 0.0016 18.1 0.4 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Phage_holin_3_6 PF07332.9 MSTRG.23306.3_2 - 2.5 8.0 9.6 6.4 6.7 5.3 2.6 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Arrestin_N PF00339.27 MSTRG.614.2_1 - 5.6e-24 84.8 0.0 1.2e-23 83.6 0.0 1.6 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.20 MSTRG.614.2_1 - 3.2e-17 63.0 0.0 4.6e-17 62.5 0.0 1.2 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain ATG16 PF08614.9 MSTRG.614.2_2 - 6.4e-43 147.2 25.6 6.4e-43 147.2 25.6 1.5 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) WD40 PF00400.30 MSTRG.614.2_2 - 6.3e-32 109.0 10.7 8e-07 29.5 0.0 7.6 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.614.2_2 - 6e-08 32.8 0.0 0.055 13.6 0.0 4.1 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain KASH_CCD PF14662.4 MSTRG.614.2_2 - 0.00055 19.7 23.6 0.00088 19.0 9.3 2.4 2 0 0 2 2 2 2 Coiled-coil region of CCDC155 or KASH Ge1_WD40 PF16529.3 MSTRG.614.2_2 - 0.0081 15.0 0.0 8.6 5.1 0.0 3.2 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Phage_GPO PF05929.9 MSTRG.614.2_2 - 0.35 10.3 10.4 0.45 10.0 9.4 1.7 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase Jnk-SapK_ap_N PF09744.7 MSTRG.614.2_2 - 0.46 10.5 18.7 1.5 8.9 18.7 1.8 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Fez1 PF06818.13 MSTRG.614.2_2 - 0.59 10.4 22.6 0.62 10.3 21.5 1.5 1 1 0 1 1 1 0 Fez1 APG6 PF04111.10 MSTRG.614.2_2 - 1.3 8.2 20.9 2.1 7.5 20.9 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4407 PF14362.4 MSTRG.614.2_2 - 1.6 7.9 20.8 3.1 6.9 20.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.17 MSTRG.614.2_2 - 2.4 5.8 11.5 3.7 5.2 11.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1664 PF07889.10 MSTRG.614.2_2 - 2.7 7.9 4.5 5.2 6.9 4.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) ADIP PF11559.6 MSTRG.614.2_2 - 3.5 7.5 23.4 0.0099 15.8 10.3 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Syntaxin-6_N PF09177.9 MSTRG.614.2_2 - 4.7 7.7 11.4 0.76 10.2 2.2 2.6 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Globin PF00042.20 MSTRG.3508.1_2 - 1.9e-25 89.4 0.0 3.6e-25 88.5 0.0 1.4 1 0 0 1 1 1 1 Globin PXA PF02194.13 MSTRG.25247.1_3 - 4e-37 127.5 1.3 2.5e-36 124.9 0.5 2.4 2 0 0 2 2 2 1 PXA domain PX PF00787.22 MSTRG.25247.1_3 - 4e-20 71.7 3.4 4.6e-20 71.6 0.9 2.4 2 1 0 2 2 2 1 PX domain Nexin_C PF08628.10 MSTRG.25247.1_3 - 3.7e-17 62.8 0.0 1.2e-16 61.2 0.0 1.9 2 0 0 2 2 2 1 Sorting nexin C terminal RGS PF00615.17 MSTRG.25247.1_3 - 1.2e-12 47.9 2.3 4.6e-12 46.1 2.3 2.0 1 0 0 1 1 1 1 Regulator of G protein signaling domain Rossmann-like PF10727.7 MSTRG.18877.1_3 - 0.067 12.9 0.0 0.17 11.6 0.0 1.6 2 0 0 2 2 2 0 Rossmann-like domain Pkinase PF00069.23 MSTRG.14062.1_1 - 2.7e-32 112.0 0.0 4e-32 111.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.14062.1_1 - 7.5e-32 110.5 0.0 1.2e-31 109.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase TGF_beta_GS PF08515.10 MSTRG.14062.1_1 - 1e-13 50.4 0.5 2e-13 49.4 0.5 1.5 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Activin_recp PF01064.21 MSTRG.14062.1_1 - 5.1e-07 30.5 13.2 5.1e-07 30.5 13.2 2.8 2 0 0 2 2 2 1 Activin types I and II receptor domain APH PF01636.21 MSTRG.14062.1_1 - 0.029 14.2 0.0 0.048 13.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family NEMP PF10225.7 MSTRG.4450.1_2 - 1.1e-83 280.6 4.3 1.8e-83 279.9 4.3 1.3 1 0 0 1 1 1 1 NEMP family Motile_Sperm PF00635.24 MSTRG.4450.1_2 - 0.13 12.0 0.2 0.26 11.0 0.2 1.4 1 0 0 1 1 1 0 MSP (Major sperm protein) domain FAM117 PF15388.4 MSTRG.12620.1_2 - 3.1e-95 319.0 8.2 3.1e-95 319.0 8.2 1.9 2 0 0 2 2 2 1 Protein Family FAM117 Cystatin PF00031.19 MSTRG.22231.1_2 - 4.8e-13 49.1 0.0 1.1e-06 28.7 0.0 2.3 2 0 0 2 2 2 2 Cystatin domain DUF1272 PF06906.9 MSTRG.22231.1_2 - 0.0079 16.1 0.4 0.027 14.4 0.4 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1272) Ank_5 PF13857.4 MSTRG.526.1_1 - 3.3e-06 27.2 0.0 6.7e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.526.1_1 - 4.3e-05 23.6 0.2 9.5e-05 22.6 0.2 1.6 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.5 MSTRG.526.1_1 - 5.3e-05 23.6 0.0 9.9e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.4 MSTRG.526.1_1 - 0.0023 18.1 0.0 0.0064 16.8 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeat Ank_4 PF13637.4 MSTRG.526.1_1 - 0.013 16.0 0.0 0.033 14.7 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_4 PF13637.4 MSTRG.526.1_2 - 0.00012 22.5 0.0 0.00024 21.5 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.526.1_2 - 0.0003 20.8 0.0 0.00086 19.5 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.5 MSTRG.526.1_2 - 0.00051 20.4 0.0 0.00096 19.6 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.28 MSTRG.526.1_2 - 0.0024 18.1 0.2 0.0052 17.1 0.2 1.6 1 0 0 1 1 1 1 Ankyrin repeat Ank_5 PF13857.4 MSTRG.526.1_2 - 0.12 12.7 0.1 0.28 11.5 0.1 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) ST7 PF04184.10 MSTRG.27013.4_2 - 1.3e-287 954.4 5.8 4e-285 946.3 5.8 2.0 1 1 0 1 1 1 1 ST7 protein TPR_19 PF14559.4 MSTRG.27013.4_2 - 0.00024 21.4 0.1 0.00024 21.4 0.1 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.27013.4_2 - 0.013 16.0 0.2 0.049 14.1 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.27013.4_2 - 0.016 15.1 1.8 2.7 8.2 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.27013.4_2 - 0.04 14.1 0.2 0.12 12.5 0.0 1.8 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.27013.4_2 - 0.057 13.1 0.6 15 5.5 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat zf-SAP30 PF13866.4 MSTRG.25716.1_1 - 8.5e-37 124.9 4.8 8.5e-37 124.9 4.8 2.3 2 0 0 2 2 2 1 SAP30 zinc-finger SAP30_Sin3_bdg PF13867.4 MSTRG.25716.1_1 - 7e-25 87.0 0.8 1.3e-24 86.1 0.8 1.5 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 Trypsin PF00089.24 MSTRG.10186.1_3 - 3.2e-63 213.3 0.1 4.4e-63 212.9 0.1 1.2 1 0 0 1 1 1 1 Trypsin Kringle PF00051.16 MSTRG.10186.1_3 - 1.1e-14 54.3 6.3 1.1e-14 54.3 6.3 2.9 3 0 0 3 3 3 1 Kringle domain Trypsin_2 PF13365.4 MSTRG.10186.1_3 - 1.8e-07 32.0 0.0 3.9e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF316 PF03761.13 MSTRG.10186.1_3 - 2.1e-05 24.1 0.0 0.19 11.1 0.0 2.2 2 0 0 2 2 2 2 Chymotrypsin family Peptidase-S1 EGF_2 PF07974.11 MSTRG.10186.1_3 - 0.04 14.2 2.6 0.26 11.6 2.6 2.5 1 0 0 1 1 1 0 EGF-like domain EGF PF00008.25 MSTRG.10186.1_3 - 0.11 12.7 1.4 0.49 10.6 1.4 2.2 1 0 0 1 1 1 0 EGF-like domain RhoGAP PF00620.25 MSTRG.4161.2_2 - 2.6e-33 114.8 0.1 5.6e-33 113.8 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain SMP_2 PF10144.7 MSTRG.5613.1_1 - 0.027 14.0 0.0 0.028 13.9 0.0 1.1 1 0 0 1 1 1 0 Bacterial virulence factor haemolysin YqzH PF14164.4 MSTRG.5613.1_1 - 2.3 8.2 7.4 3.7 7.6 0.8 2.2 1 1 1 2 2 2 0 YqzH-like protein Homeobox PF00046.27 MSTRG.9421.1_1 - 5.1e-08 32.5 0.9 9.5e-08 31.6 0.9 1.5 1 0 0 1 1 1 1 Homeobox domain Olfactory_mark PF06554.10 MSTRG.27058.1_2 - 4.7e-08 32.8 0.1 8.8e-08 31.9 0.1 1.5 1 1 0 1 1 1 1 Olfactory marker protein IncA PF04156.12 MSTRG.6218.1_1 - 0.0042 16.8 0.2 0.0064 16.2 0.2 1.2 1 0 0 1 1 1 1 IncA protein K-box PF01486.15 MSTRG.6218.1_1 - 0.041 13.9 2.4 0.074 13.1 2.4 1.4 1 0 0 1 1 1 0 K-box region Arrestin_N PF00339.27 MSTRG.8110.1_1 - 1e-38 132.5 0.0 1.9e-34 118.7 0.0 2.2 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.20 MSTRG.8110.1_1 - 2.4e-25 89.4 0.0 3.7e-25 88.7 0.0 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain eIF-5a PF01287.18 MSTRG.9031.1_2 - 5e-24 84.1 0.4 7.7e-24 83.5 0.4 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.10 MSTRG.9031.1_2 - 0.0018 18.1 0.2 0.0043 16.9 0.0 1.8 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain OATP PF03137.18 MSTRG.14437.1_2 - 4.6e-175 582.9 12.4 5.9e-175 582.5 12.4 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 MSTRG.14437.1_2 - 1.7e-25 89.6 9.3 1.7e-25 89.6 9.3 2.8 3 1 0 3 3 3 2 Major Facilitator Superfamily Kazal_2 PF07648.13 MSTRG.14437.1_2 - 3.9e-07 30.0 0.7 1.2e-06 28.5 0.7 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 MSTRG.14437.1_2 - 0.00055 19.8 2.7 0.0016 18.2 2.7 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain MFS_1_like PF12832.5 MSTRG.14437.1_2 - 0.03 13.0 0.3 0.23 10.2 0.1 2.1 1 1 1 2 2 2 0 MFS_1 like family TBSV_P22 PF03558.11 MSTRG.23614.3_3 - 0.14 11.7 0.0 0.16 11.5 0.0 1.1 1 0 0 1 1 1 0 TBSV core protein P21/P22 zf-C2H2 PF00096.24 MSTRG.5576.4_3 - 8.6e-06 25.8 20.1 0.074 13.4 0.3 3.2 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.5576.4_3 - 0.03 15.0 19.5 0.32 11.8 3.9 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_8 PF15909.3 MSTRG.5576.4_3 - 0.059 13.5 4.2 0.16 12.2 4.2 1.7 1 1 0 1 1 1 0 C2H2-type zinc ribbon COesterase PF00135.26 MSTRG.2332.1_1 - 6.8e-144 480.4 0.0 7.8e-144 480.2 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 MSTRG.2332.1_1 - 3e-06 27.1 0.1 1e-05 25.3 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Ribosomal_S13_N PF08069.10 MSTRG.2332.1_1 - 0.1 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain Pkinase_Tyr PF07714.15 MSTRG.5582.2_1 - 3.5e-68 229.6 0.0 5.3e-68 229.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.5582.2_1 - 3.4e-27 95.3 0.0 5.1e-27 94.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.5582.2_3 - 5e-28 98.0 0.1 7.2e-28 97.4 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.5582.2_3 - 1.3e-13 50.8 0.1 1.8e-13 50.3 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Ig_2 PF13895.4 MSTRG.5582.2_3 - 8.4e-08 32.3 0.6 1.6e-05 25.0 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.5582.2_3 - 1.7e-06 28.4 0.2 0.0024 18.3 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 MSTRG.5582.2_3 - 7.9e-05 22.5 0.1 0.019 14.9 0.0 2.9 2 0 0 2 2 2 1 Immunoglobulin I-set domain Neur_chan_memb PF02932.14 MSTRG.3981.1_1 - 1.8e-67 227.7 15.1 2.4e-51 175.0 12.1 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 MSTRG.3981.1_1 - 1e-65 221.1 1.1 1.3e-65 220.7 1.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF1129 PF06570.9 MSTRG.3981.1_1 - 6.8 6.0 8.5 8.4 5.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) OTU PF02338.17 MSTRG.26290.1_2 - 2.7e-30 105.3 0.0 4.9e-30 104.5 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease zf-A20 PF01754.14 MSTRG.26290.1_2 - 4.2e-14 52.0 6.7 1.4e-07 31.2 0.1 2.8 2 0 0 2 2 2 2 A20-like zinc finger TPK_B1_binding PF04265.12 MSTRG.26290.1_2 - 0.19 11.3 0.1 0.45 10.1 0.1 1.6 1 0 0 1 1 1 0 Thiamin pyrophosphokinase, vitamin B1 binding domain TPR_14 PF13428.4 MSTRG.308.1_3 - 6.2e-18 63.8 19.3 0.0087 16.7 0.0 11.7 7 3 5 12 12 11 3 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.308.1_3 - 4.2e-10 39.9 7.6 1.7 9.1 0.0 8.6 8 1 0 9 9 8 2 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.308.1_3 - 2.3e-09 37.3 12.0 1.4e-05 25.1 0.1 5.5 4 1 2 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.308.1_3 - 2.6e-09 36.4 21.6 0.014 15.3 0.2 8.9 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.308.1_3 - 1.5e-07 31.0 20.8 0.048 13.8 0.1 9.0 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_15 PF13429.4 MSTRG.308.1_3 - 7.4e-07 28.5 8.8 0.011 14.8 3.5 4.3 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.308.1_3 - 9.9e-07 29.2 10.2 0.13 12.9 0.0 5.6 4 1 1 5 5 5 1 Tetratricopeptide repeat NRDE-2 PF08424.8 MSTRG.308.1_3 - 5.1e-05 22.4 14.7 0.0023 17.0 0.2 5.7 3 3 2 5 5 5 2 NRDE-2, necessary for RNA interference Suf PF05843.12 MSTRG.308.1_3 - 0.00014 21.8 20.5 0.034 14.0 6.9 6.4 5 1 1 6 6 6 2 Suppressor of forked protein (Suf) TPR_7 PF13176.4 MSTRG.308.1_3 - 0.0031 17.3 7.2 0.19 11.7 0.0 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.10 MSTRG.308.1_3 - 0.0032 17.3 18.6 1.3 8.9 2.0 6.4 4 2 3 7 7 7 1 Mad3/BUB1 homology region 1 SNAP PF14938.4 MSTRG.308.1_3 - 0.0043 16.4 12.0 1.2 8.4 0.0 4.8 2 1 0 4 4 4 1 Soluble NSF attachment protein, SNAP DUF4515 PF14988.4 MSTRG.308.1_3 - 0.023 14.4 1.5 0.069 12.9 1.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) ANAPC3 PF12895.5 MSTRG.308.1_3 - 0.042 13.9 4.7 0.69 10.0 0.1 4.5 4 1 1 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.18 MSTRG.308.1_3 - 0.09 12.9 2.0 1.1 9.6 0.1 3.9 5 0 0 5 5 3 0 PPR repeat TPR_1 PF00515.26 MSTRG.308.1_3 - 0.14 11.9 17.0 0.35 10.6 0.1 7.0 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.308.1_3 - 1.5 9.5 12.4 2.1e+02 2.8 0.0 7.8 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.308.1_3 - 2.4 8.6 15.2 57 4.3 0.1 7.9 11 0 0 11 11 7 0 Tetratricopeptide repeat Usp PF00582.24 MSTRG.308.1_3 - 3.5 8.0 4.3 36 4.7 0.1 2.9 3 0 0 3 3 3 0 Universal stress protein family Exonuc_VII_S PF02609.14 MSTRG.308.1_3 - 7.4 6.6 6.5 4.5 7.3 0.0 3.9 4 0 0 4 4 3 0 Exonuclease VII small subunit TMEM132D_C PF15706.3 MSTRG.14303.1_3 - 0.17 11.5 0.9 0.33 10.6 0.9 1.5 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term SNF PF00209.16 MSTRG.12443.1_3 - 7.1e-65 219.5 8.9 8.1e-65 219.4 8.9 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Ank_2 PF12796.5 MSTRG.15222.1_1 - 2.4e-23 82.4 0.1 6.2e-15 55.4 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.15222.1_1 - 2.7e-15 56.4 0.0 6.2e-11 42.5 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.15222.1_1 - 6.4e-13 47.5 0.0 1.6e-06 27.9 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.4 MSTRG.15222.1_1 - 2.3e-12 46.8 0.0 3.7e-06 27.0 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.15222.1_1 - 3.4e-10 39.8 0.5 0.00046 20.4 0.0 3.4 4 0 0 4 4 4 2 Ankyrin repeat TruD PF01142.16 MSTRG.21628.5_1 - 8.9e-75 251.9 0.0 2.7e-68 230.6 0.0 2.4 2 1 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) PRELI PF04707.12 MSTRG.19167.3_1 - 1.6e-51 174.1 0.4 2.1e-51 173.7 0.4 1.1 1 0 0 1 1 1 1 PRELI-like family RPE65 PF03055.13 MSTRG.12827.1_2 - 3.9e-105 352.3 0.2 4.4e-105 352.1 0.2 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein AKAP28 PF14469.4 MSTRG.29060.1_3 - 0.03 13.9 0.2 0.037 13.7 0.2 1.1 1 0 0 1 1 1 0 28 kDa A-kinase anchor REC114-like PF15165.4 MSTRG.5471.2_3 - 9.5e-14 51.6 0.0 1.2e-13 51.3 0.0 1.1 1 0 0 1 1 1 1 Meiotic recombination protein REC114-like ATG16 PF08614.9 MSTRG.16799.2_3 - 0.00064 19.8 16.2 0.0011 19.1 16.2 1.4 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Golgin_A5 PF09787.7 MSTRG.16799.2_3 - 0.001 18.5 15.6 0.0014 18.0 15.6 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 5 IncA PF04156.12 MSTRG.16799.2_3 - 0.0036 17.0 13.1 0.0056 16.4 13.1 1.4 1 0 0 1 1 1 1 IncA protein GAS PF13851.4 MSTRG.16799.2_3 - 0.01 15.1 7.8 0.01 15.1 7.8 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding TMCO5 PF14992.4 MSTRG.16799.2_3 - 0.01 15.3 12.9 0.016 14.7 12.9 1.2 1 0 0 1 1 1 0 TMCO5 family Spc7 PF08317.9 MSTRG.16799.2_3 - 0.053 12.3 19.7 0.19 10.5 17.4 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein Mnd1 PF03962.13 MSTRG.16799.2_3 - 0.075 12.8 12.6 0.13 12.0 12.6 1.3 1 0 0 1 1 1 0 Mnd1 family Jnk-SapK_ap_N PF09744.7 MSTRG.16799.2_3 - 0.082 13.0 16.7 0.16 12.0 16.7 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 HMMR_N PF15905.3 MSTRG.16799.2_3 - 0.083 12.2 15.7 0.12 11.7 15.7 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Exonuc_VII_L PF02601.13 MSTRG.16799.2_3 - 0.095 12.1 8.9 0.13 11.7 8.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit LMBR1 PF04791.14 MSTRG.16799.2_3 - 0.15 10.8 6.1 0.2 10.4 6.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein HAUS-augmin3 PF14932.4 MSTRG.16799.2_3 - 0.18 11.2 14.0 0.28 10.5 14.0 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF4200 PF13863.4 MSTRG.16799.2_3 - 0.2 11.9 19.5 0.37 11.0 19.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Bacillus_HBL PF05791.9 MSTRG.16799.2_3 - 0.28 10.8 3.5 0.45 10.1 3.5 1.3 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) IFT46_B_C PF12317.6 MSTRG.16799.2_3 - 0.46 10.1 3.4 0.67 9.5 3.4 1.2 1 0 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal V_ATPase_I PF01496.17 MSTRG.16799.2_3 - 0.6 7.8 10.9 0.81 7.4 10.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Atg14 PF10186.7 MSTRG.16799.2_3 - 0.78 8.6 9.9 1.2 8.1 9.9 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fib_alpha PF08702.8 MSTRG.16799.2_3 - 2.1 8.4 13.1 2.7 8.0 12.1 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Troponin PF00992.18 MSTRG.16799.2_3 - 3.1 8.0 18.2 8.3 6.6 18.2 1.6 1 1 0 1 1 1 0 Troponin DUF4407 PF14362.4 MSTRG.16799.2_3 - 3.5 6.8 11.0 5.6 6.1 11.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ly49 PF08391.8 MSTRG.16799.2_3 - 3.8 7.8 5.5 6.7 7.0 5.5 1.4 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Herpes_UL25 PF01499.14 MSTRG.16799.2_3 - 6.4 5.0 13.3 8.6 4.6 12.7 1.4 1 1 1 2 2 2 0 Herpesvirus UL25 family IP_trans PF02121.16 MSTRG.24695.1_2 - 8e-81 271.1 1.8 1.1e-80 270.6 1.8 1.1 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein IP_trans PF02121.16 MSTRG.24695.1_3 - 8e-28 97.5 0.1 1.2e-27 96.9 0.1 1.2 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein C1-set PF07654.13 MSTRG.20777.4_3 - 4.1e-22 78.3 0.3 8.3e-22 77.3 0.3 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_II_beta PF00969.17 MSTRG.20777.4_3 - 1.3e-05 25.1 0.3 5.2e-05 23.2 0.0 2.0 2 0 0 2 2 2 1 Class II histocompatibility antigen, beta domain C2-set_2 PF08205.10 MSTRG.20777.4_3 - 9.1e-05 22.3 0.6 0.00051 19.9 0.1 2.2 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 MSTRG.20777.4_3 - 0.00039 20.8 0.2 0.00078 19.9 0.2 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Myco_arth_vir_N PF09610.8 MSTRG.6095.3_1 - 0.18 11.8 0.3 0.56 10.2 0.3 1.8 1 0 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Atg14 PF10186.7 MSTRG.22755.1_3 - 2.5e-16 59.5 6.9 4.4e-16 58.7 6.9 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 APG6 PF04111.10 MSTRG.22755.1_3 - 0.00057 19.3 5.1 0.0023 17.3 5.1 1.8 1 1 0 1 1 1 1 Autophagy protein Apg6 C2 PF00168.28 MSTRG.22755.1_3 - 0.0076 16.4 0.0 0.043 14.0 0.0 2.1 2 0 0 2 2 2 1 C2 domain RNA_pol_Rpb1_7 PF04990.10 MSTRG.22755.1_3 - 0.14 12.0 1.8 0.25 11.2 1.8 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 7 ADIP PF11559.6 MSTRG.22755.1_3 - 7.5 6.5 16.4 5.2 7.0 13.3 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding SIS PF01380.20 MSTRG.10316.1_1 - 3.6e-64 214.3 0.1 5.9e-35 119.8 0.0 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.4 MSTRG.10316.1_1 - 1.9e-17 63.5 0.0 6.8e-17 61.8 0.0 1.8 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_7 PF13537.4 MSTRG.10316.1_1 - 2.8e-14 53.0 0.0 6.2e-13 48.6 0.0 2.3 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_4 PF13230.4 MSTRG.10316.1_1 - 0.00065 18.5 0.0 0.0013 17.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.4 MSTRG.10316.1_1 - 0.014 15.3 0.0 0.029 14.2 0.0 1.6 1 0 0 1 1 1 0 SIS domain GATase_2 PF00310.19 MSTRG.10316.1_1 - 0.017 13.7 0.0 0.034 12.7 0.0 1.4 1 0 0 1 1 1 0 Glutamine amidotransferases class-II AA_permease_2 PF13520.4 MSTRG.9502.3_1 - 9.9e-05 21.2 0.1 0.00014 20.7 0.1 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.19 MSTRG.9502.3_1 - 0.015 13.8 0.1 0.021 13.3 0.1 1.1 1 0 0 1 1 1 0 Amino acid permease AA_permease_2 PF13520.4 MSTRG.9502.3_2 - 2.2e-46 158.4 22.9 2.9e-46 158.0 22.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.19 MSTRG.9502.3_2 - 1.7e-39 135.6 20.8 2.3e-39 135.2 20.8 1.1 1 0 0 1 1 1 1 Amino acid permease Trep_Strep PF09605.8 MSTRG.9502.3_2 - 0.0037 17.2 2.2 0.0037 17.2 2.2 3.3 3 1 0 3 3 3 1 Hypothetical bacterial integral membrane protein (Trep_Strep) DNA_pol_B PF00136.19 MSTRG.365.2_2 - 3.8e-64 217.0 0.0 5.3e-64 216.5 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.17 MSTRG.365.2_2 - 1.2e-52 179.0 0.0 1.9e-52 178.4 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.6 MSTRG.365.2_2 - 2.7e-19 68.9 9.5 7.5e-19 67.5 9.5 1.8 1 0 0 1 1 1 1 DNA polymerase alpha subunit p180 N terminal DNA_pol_B_2 PF03175.11 MSTRG.365.2_2 - 0.00098 17.9 0.0 0.0025 16.6 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral CSD PF00313.20 MSTRG.6305.2_2 - 3.8e-26 90.6 0.5 8.7e-26 89.4 0.5 1.6 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.9 MSTRG.6305.2_2 - 0.022 14.3 0.0 0.056 13.0 0.0 1.6 1 0 0 1 1 1 0 Ribonuclease B OB domain Epimerase_2 PF02350.17 MSTRG.11466.4_2 - 1.2e-66 224.8 0.0 1.8e-66 224.3 0.0 1.2 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase ROK PF00480.18 MSTRG.11466.4_2 - 2.4e-54 184.7 0.9 4.1e-54 183.9 0.9 1.4 1 0 0 1 1 1 1 ROK family DRTGG PF07085.10 MSTRG.11466.4_2 - 0.0013 18.4 0.1 0.0031 17.1 0.1 1.6 1 0 0 1 1 1 1 DRTGG domain FGGY_N PF00370.19 MSTRG.11466.4_2 - 0.031 13.7 0.0 0.055 12.9 0.0 1.4 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain Hexokinase_1 PF00349.19 MSTRG.11466.4_2 - 0.042 13.7 0.0 0.17 11.7 0.0 1.9 1 1 1 2 2 2 0 Hexokinase NAD_binding_2 PF03446.13 MSTRG.2160.1_3 - 3.1e-36 124.8 0.0 5.2e-36 124.1 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.4 MSTRG.2160.1_3 - 8.7e-20 71.1 1.5 1.4e-19 70.4 1.5 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase PWWP PF00855.15 MSTRG.2160.1_3 - 2.1e-18 66.4 0.3 3.7e-18 65.6 0.3 1.4 1 0 0 1 1 1 1 PWWP domain F420_oxidored PF03807.15 MSTRG.2160.1_3 - 7e-06 26.4 0.0 1.4e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.18 MSTRG.2160.1_3 - 0.0039 17.1 0.0 0.007 16.3 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.14 MSTRG.2160.1_3 - 0.0054 16.3 0.0 0.0084 15.6 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.17 MSTRG.2160.1_3 - 0.0056 15.9 0.0 0.0093 15.2 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.16 MSTRG.2160.1_3 - 0.053 13.3 0.0 0.098 12.4 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.16 MSTRG.2160.1_3 - 0.058 13.5 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DUF1048 PF06304.9 MSTRG.2160.1_3 - 0.17 12.2 0.0 0.32 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1048) Arf PF00025.19 MSTRG.11992.1_2 - 3.8e-23 81.7 0.1 4.8e-23 81.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family ArgK PF03308.14 MSTRG.11992.1_2 - 0.14 11.0 0.0 0.18 10.6 0.0 1.1 1 0 0 1 1 1 0 ArgK protein VPR PF00522.16 MSTRG.22992.1_3 - 0.04 13.8 0.1 0.055 13.4 0.1 1.3 1 1 0 1 1 1 0 VPR/VPX protein Mito_morph_reg PF14972.4 MSTRG.6442.2_2 - 1.9e-35 121.7 0.8 2.6e-35 121.3 0.8 1.1 1 0 0 1 1 1 1 Mitochondrial morphogenesis regulator Mito_morph_reg PF14972.4 MSTRG.6442.2_3 - 2.1e-21 76.1 0.4 3e-21 75.6 0.4 1.1 1 0 0 1 1 1 1 Mitochondrial morphogenesis regulator IRF-2BP1_2 PF11261.6 MSTRG.6442.2_3 - 0.19 11.1 3.3 0.47 9.9 0.1 2.3 2 0 0 2 2 2 0 Interferon regulatory factor 2-binding protein zinc finger zf-C3H1 PF10650.7 MSTRG.9772.1_2 - 2.4e-09 36.6 3.1 2.4e-09 36.6 3.1 2.6 3 0 0 3 3 3 1 Putative zinc-finger domain TPR_14 PF13428.4 MSTRG.9772.1_2 - 0.00072 20.0 1.8 0.26 12.1 0.0 4.0 2 1 2 4 4 4 2 Tetratricopeptide repeat COMPASS-Shg1 PF05205.10 MSTRG.9772.1_2 - 0.067 13.8 3.3 0.21 12.2 3.3 1.9 1 0 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component shg1 Zona_pellucida PF00100.21 MSTRG.26492.4_1 - 3.1e-37 128.6 4.5 3.1e-37 128.6 4.5 2.3 3 0 0 3 3 3 1 Zona pellucida-like domain CUB PF00431.18 MSTRG.26492.4_1 - 2.9e-20 72.5 0.3 6.9e-20 71.3 0.3 1.7 1 0 0 1 1 1 1 CUB domain Somatomedin_B PF01033.15 MSTRG.26492.4_1 - 2.6e-16 59.6 112.2 4.4e-05 23.7 19.0 5.5 5 0 0 5 5 5 4 Somatomedin B domain Coq4 PF05019.11 MSTRG.26492.4_2 - 3.7 6.7 7.8 3.4 6.8 0.5 2.9 1 1 2 3 3 3 0 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 TPR_15 PF13429.4 MSTRG.15091.1_3 - 0.051 12.6 0.0 0.077 12.1 0.0 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat Myb_DNA-bind_4 PF13837.4 MSTRG.11699.2_1 - 3.8e-125 408.5 22.9 2.3e-20 72.6 0.3 7.4 7 0 0 7 7 7 7 Myb/SANT-like DNA-binding domain TINF2_N PF14973.4 MSTRG.11699.2_1 - 2.3e-54 183.6 0.4 2.3e-54 183.6 0.4 2.8 3 0 0 3 3 3 1 TERF1-interacting nuclear factor 2 N-terminus Myb_DNA-bind_3 PF12776.5 MSTRG.11699.2_1 - 1.3e-18 67.5 14.4 0.11 13.2 0.2 7.3 7 0 0 7 7 7 7 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.7 MSTRG.11699.2_1 - 1.4e-13 50.8 23.7 0.052 13.7 0.1 7.4 7 0 0 7 7 7 5 Alcohol dehydrogenase transcription factor Myb/SANT-like DUF573 PF04504.12 MSTRG.11699.2_1 - 5.5e-10 39.6 11.9 2.7 8.6 0.2 7.3 7 0 0 7 7 7 4 Protein of unknown function, DUF573 Myb_DNA-bind_6 PF13921.4 MSTRG.11699.2_1 - 3.3e-07 30.3 20.6 0.13 12.4 0.1 7.7 7 0 0 7 7 7 2 Myb-like DNA-binding domain HupH_C PF04809.11 MSTRG.11699.2_1 - 0.062 12.8 0.0 27 4.4 0.0 4.1 5 0 0 5 5 5 0 HupH hydrogenase expression protein, C-terminal conserved region UPF0004 PF00919.18 MSTRG.11699.2_1 - 0.3 11.0 1.9 42 4.2 0.0 3.7 4 0 0 4 4 4 0 Uncharacterized protein family UPF0004 Myb_DNA-binding PF00249.29 MSTRG.11699.2_1 - 0.6 10.2 22.3 54 3.9 0.0 9.0 8 3 0 8 8 8 0 Myb-like DNA-binding domain SAM_1 PF00536.28 MSTRG.19455.1_1 - 2.7e-18 66.0 1.1 1.2e-12 48.0 0.2 2.5 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 MSTRG.19455.1_1 - 1.2e-17 63.6 0.7 4.5e-09 36.2 0.1 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) PRIMA1 PF16101.3 MSTRG.19455.1_1 - 0.32 10.9 4.3 0.66 9.9 4.3 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 C2 PF00168.28 MSTRG.2995.1_1 - 3.9e-14 52.7 0.0 6.4e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 C2 domain RBD-FIP PF09457.8 MSTRG.2995.1_1 - 2.6e-10 39.9 1.4 4e-10 39.3 1.4 1.3 1 0 0 1 1 1 1 FIP domain Ras PF00071.20 MSTRG.24239.1_1 - 3.8e-54 182.5 0.3 5e-54 182.1 0.3 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.24239.1_1 - 3.5e-19 69.1 0.0 5.4e-19 68.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.24239.1_1 - 2.9e-07 30.0 0.1 4.3e-07 29.4 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 MSTRG.24239.1_1 - 0.0031 16.9 0.5 0.009 15.4 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 MSTRG.24239.1_1 - 0.016 15.2 0.0 0.03 14.3 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase G-alpha PF00503.18 MSTRG.24239.1_1 - 0.12 11.4 0.0 0.25 10.3 0.0 1.4 1 1 0 1 1 1 0 G-protein alpha subunit Actin PF00022.17 MSTRG.11828.1_3 - 7.4e-151 502.2 0.0 1.8e-150 501.0 0.0 1.5 1 1 0 1 1 1 1 Actin TEA PF01285.16 MSTRG.2680.1_3 - 7e-27 94.5 0.0 8.8e-27 94.2 0.0 1.1 1 0 0 1 1 1 1 TEA/ATTS domain family Atrophin-1 PF03154.13 MSTRG.3206.4_3 - 0 1733.8 155.0 0 1733.5 155.0 1.1 1 0 0 1 1 1 1 Atrophin-1 family GATA PF00320.25 MSTRG.3206.4_3 - 7.4e-11 41.3 2.6 1.6e-10 40.3 2.6 1.6 1 0 0 1 1 1 1 GATA zinc finger MIP-T3 PF10243.7 MSTRG.3206.4_3 - 0.0012 17.6 5.8 0.0012 17.6 5.8 2.3 2 0 0 2 2 2 1 Microtubule-binding protein MIP-T3 COP23 PF14218.4 MSTRG.27977.3_2 - 0.039 13.6 4.2 2.2 7.9 0.4 2.4 2 0 0 2 2 2 0 Circadian oscillating protein COP23 RVT_1 PF00078.25 MSTRG.1835.1_2 - 1.9e-06 27.5 0.1 2.5e-06 27.1 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2_2 PF13465.4 MSTRG.1835.1_3 - 1.2e-73 240.4 66.8 2.3e-09 37.1 0.7 10.6 10 0 0 10 10 10 9 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.1835.1_3 - 5.2e-44 146.2 79.7 3e-06 27.2 3.6 10.1 10 0 0 10 10 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.1835.1_3 - 2e-34 115.2 69.6 2.3e-05 24.7 2.5 10.3 9 0 0 9 9 9 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.1835.1_3 - 1.3e-14 53.9 34.4 0.0031 17.7 0.4 9.7 9 0 0 9 9 9 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 MSTRG.1835.1_3 - 3.5e-13 49.0 61.9 0.00084 19.1 1.4 10.9 9 3 0 9 9 9 6 C2H2-type zinc finger zf-Di19 PF05605.10 MSTRG.1835.1_3 - 7.1e-09 35.7 42.1 0.00038 20.5 1.4 6.6 3 1 2 6 6 6 5 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.8 MSTRG.1835.1_3 - 7.8e-09 35.4 31.5 0.11 12.5 2.3 7.8 5 3 2 7 7 7 5 Zinc ribbon domain zf-met PF12874.5 MSTRG.1835.1_3 - 2e-07 31.0 59.5 0.0082 16.4 2.0 9.9 10 0 0 10 10 9 4 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.5 MSTRG.1835.1_3 - 1.1e-06 28.7 47.5 0.081 13.1 0.8 9.0 1 1 7 8 8 8 4 C2H2 type zinc-finger (2 copies) zinc_ribbon_15 PF17032.3 MSTRG.1835.1_3 - 1.5e-05 25.6 27.5 0.28 11.8 0.8 5.6 1 1 5 7 7 7 6 zinc-ribbon family HypA PF01155.17 MSTRG.1835.1_3 - 5.4e-05 23.0 24.0 0.51 10.2 0.6 5.2 1 1 4 5 5 5 4 Hydrogenase/urease nickel incorporation, metallochaperone, hypA LIM PF00412.20 MSTRG.1835.1_3 - 0.0001 22.3 44.5 0.91 9.7 1.4 8.5 4 2 4 8 8 8 5 LIM domain Elf1 PF05129.11 MSTRG.1835.1_3 - 0.00015 21.6 37.4 0.019 14.9 2.2 6.0 1 1 6 7 7 7 5 Transcription elongation factor Elf1 like CpXC PF14353.4 MSTRG.1835.1_3 - 0.0028 17.5 28.0 8.1 6.4 0.1 8.6 2 2 3 7 7 7 0 CpXC protein MBD PF01429.17 MSTRG.1835.1_3 - 0.003 17.1 1.2 10 5.8 0.4 5.0 2 2 0 2 2 2 0 Methyl-CpG binding domain DUF2180 PF09947.7 MSTRG.1835.1_3 - 0.0047 16.7 16.4 6.5 6.7 0.5 6.0 1 1 6 7 7 7 0 Uncharacterized protein conserved in archaea (DUF2180) Chordopox_RPO7 PF05864.10 MSTRG.1835.1_3 - 0.013 15.6 12.7 3 8.0 0.1 6.6 8 0 0 8 8 7 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) ADK_lid PF05191.12 MSTRG.1835.1_3 - 0.013 15.3 20.1 1.6 8.7 0.2 6.0 3 1 3 6 6 6 0 Adenylate kinase, active site lid DUF3268 PF11672.6 MSTRG.1835.1_3 - 0.016 15.4 17.3 1.8 8.8 0.2 4.7 1 1 5 7 7 7 0 zinc-finger-containing domain YhfH PF14149.4 MSTRG.1835.1_3 - 0.15 11.9 23.1 19 5.2 0.0 8.2 9 0 0 9 9 9 0 YhfH-like protein DUF2256 PF10013.7 MSTRG.1835.1_3 - 0.18 11.8 27.7 10 6.2 0.1 8.8 9 0 0 9 9 9 0 Uncharacterized protein conserved in bacteria (DUF2256) zinc_ribbon_4 PF13717.4 MSTRG.1835.1_3 - 0.23 11.3 35.6 2.7 7.9 2.4 8.2 6 3 0 6 6 6 0 zinc-ribbon domain zf-C4_ClpX PF06689.11 MSTRG.1835.1_3 - 0.29 10.9 33.5 1.6 8.5 1.0 7.0 8 0 0 8 8 7 0 ClpX C4-type zinc finger BolA PF01722.16 MSTRG.1835.1_3 - 1.4 9.1 14.4 8.6 6.6 0.3 4.9 3 2 1 4 4 4 0 BolA-like protein zf-LYAR PF08790.9 MSTRG.1835.1_3 - 2.9 7.8 49.1 2.3 8.1 0.1 9.7 11 0 0 11 11 10 0 LYAR-type C2HC zinc finger C1_4 PF07975.10 MSTRG.1835.1_3 - 3.5 7.8 34.9 6.5 7.0 0.8 6.8 3 1 5 8 8 8 0 TFIIH C1-like domain TerY_C PF15616.4 MSTRG.1835.1_3 - 4.3 7.3 24.1 1.1 9.3 0.5 5.1 2 1 4 6 6 6 0 TerY-C metal binding domain Zn_Tnp_IS1595 PF12760.5 MSTRG.1835.1_3 - 5.5 6.9 39.7 1 9.3 1.7 5.7 3 1 2 6 6 6 0 Transposase zinc-ribbon domain Cadherin PF00028.15 MSTRG.16143.1_2 - 2.1e-11 44.0 0.0 4.6e-07 30.1 0.0 2.9 3 0 0 3 3 3 2 Cadherin domain PPC PF04151.13 MSTRG.16143.1_2 - 0.038 15.0 0.1 0.074 14.0 0.1 1.4 1 0 0 1 1 1 0 Bacterial pre-peptidase C-terminal domain SH3_1 PF00018.26 MSTRG.22410.1_1 - 2.3e-15 55.8 0.3 4.7e-15 54.8 0.3 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.22410.1_1 - 4e-12 45.7 0.2 7.9e-12 44.7 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain Cofilin_ADF PF00241.18 MSTRG.22410.1_1 - 8.5e-11 42.0 0.2 2.9e-10 40.3 0.0 2.1 3 0 0 3 3 3 1 Cofilin/tropomyosin-type actin-binding protein SH3_2 PF07653.15 MSTRG.22410.1_1 - 5.7e-09 35.4 0.0 1.1e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain zf-RING_2 PF13639.4 MSTRG.25474.1_2 - 7e-10 38.9 3.6 7e-10 38.9 3.6 2.5 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4 PF00097.23 MSTRG.25474.1_2 - 1.9e-07 30.7 1.7 1.9e-07 30.7 1.7 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.25474.1_2 - 1.7e-06 27.8 0.5 1.7e-06 27.8 0.5 2.2 2 0 0 2 2 1 1 RING-type zinc-finger zf-rbx1 PF12678.5 MSTRG.25474.1_2 - 1.6e-05 24.9 3.8 6.1e-05 23.1 3.8 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.4 MSTRG.25474.1_2 - 2.3e-05 24.3 0.5 0.00011 22.1 0.5 2.2 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 MSTRG.25474.1_2 - 0.00014 21.5 2.9 0.00014 21.5 2.9 2.3 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 MSTRG.25474.1_2 - 0.00018 21.3 1.0 0.00056 19.8 1.0 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.3 MSTRG.25474.1_2 - 0.002 17.6 1.3 0.002 17.6 1.3 2.7 3 0 0 3 3 3 1 RING-like zinc finger Rtf2 PF04641.10 MSTRG.25474.1_2 - 0.0044 16.3 0.9 0.0076 15.5 0.9 1.3 1 0 0 1 1 1 1 Rtf2 RING-finger zf-UDP PF14569.4 MSTRG.25474.1_2 - 0.09 12.8 0.9 0.22 11.6 0.9 1.6 1 0 0 1 1 1 0 Zinc-binding RING-finger DUF2040 PF09745.7 MSTRG.25474.1_2 - 0.12 12.3 1.8 0.2 11.6 1.8 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 55 (DUF2040) WD40 PF00400.30 MSTRG.25474.1_2 - 0.12 13.1 1.0 36 5.3 0.0 3.5 3 0 0 3 3 2 0 WD domain, G-beta repeat Lebercilin PF15619.4 MSTRG.25474.1_2 - 0.16 11.5 6.4 0.26 10.8 6.4 1.2 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease FANCL_C PF11793.6 MSTRG.25474.1_2 - 0.3 11.2 4.2 1.1 9.3 4.2 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain fn3 PF00041.19 MSTRG.10046.1_1 - 1.5e-05 25.1 0.0 1.8e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Fibronectin type III domain DUF4528 PF15031.4 MSTRG.10046.1_1 - 0.094 12.6 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4528) zf-H2C2_2 PF13465.4 MSTRG.10046.1_3 - 0.69 10.3 6.2 0.15 12.4 2.3 2.0 2 0 0 2 2 2 0 Zinc-finger double domain zf-CXXC PF02008.18 MSTRG.13088.3_2 - 3e-19 68.6 55.9 1.3e-12 47.4 25.9 3.2 3 0 0 3 3 3 2 CXXC zinc finger domain MBD PF01429.17 MSTRG.13088.3_2 - 2.4e-11 43.1 0.0 6.2e-11 41.7 0.0 1.7 1 0 0 1 1 1 1 Methyl-CpG binding domain Rox3 PF08633.8 MSTRG.13088.3_2 - 0.36 11.0 7.0 0.37 10.9 0.8 3.2 3 0 0 3 3 3 0 Rox3 mediator complex subunit CLIP1_ZNF PF16641.3 MSTRG.16860.2_2 - 2.3e-11 43.1 27.1 6.7e-07 28.9 4.6 2.7 3 0 0 3 3 3 2 CLIP1 zinc knuckle Reo_sigmaC PF04582.10 MSTRG.16860.2_2 - 2.3e-05 23.8 36.2 0.0071 15.7 7.2 4.1 1 1 3 4 4 4 4 Reovirus sigma C capsid protein Filament PF00038.19 MSTRG.16860.2_2 - 0.0025 17.3 78.3 0.41 10.0 24.8 5.4 1 1 5 6 6 6 5 Intermediate filament protein FliJ PF02050.14 MSTRG.16860.2_2 - 0.0033 17.5 20.1 0.0033 17.5 20.1 5.4 1 1 4 5 5 5 2 Flagellar FliJ protein KASH_CCD PF14662.4 MSTRG.16860.2_2 - 0.005 16.6 88.9 0.17 11.5 8.9 4.3 2 2 2 4 4 4 3 Coiled-coil region of CCDC155 or KASH Spc7 PF08317.9 MSTRG.16860.2_2 - 0.007 15.1 93.6 0.0093 14.7 22.5 5.0 1 1 3 4 4 4 2 Spc7 kinetochore protein DUF3584 PF12128.6 MSTRG.16860.2_2 - 0.0087 13.5 81.2 0.014 12.8 43.4 2.9 1 1 1 2 2 2 2 Protein of unknown function (DUF3584) TSGP1 PF07771.9 MSTRG.16860.2_2 - 0.034 14.2 6.4 0.13 12.2 6.4 2.0 1 0 0 1 1 1 0 Tick salivary peptide group 1 ATG16 PF08614.9 MSTRG.16860.2_2 - 0.056 13.5 100.3 0.049 13.7 36.2 4.9 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) CALCOCO1 PF07888.9 MSTRG.16860.2_2 - 0.074 11.5 86.6 0.013 14.0 55.4 2.2 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like zf-CCHC PF00098.21 MSTRG.16860.2_2 - 0.42 10.6 2.3 0.85 9.7 2.3 1.5 1 0 0 1 1 1 0 Zinc knuckle SASP PF00269.18 MSTRG.16860.2_2 - 0.5 10.3 7.4 2.6 8.0 0.5 3.7 2 1 1 3 3 3 0 Small, acid-soluble spore proteins, alpha/beta type IncA PF04156.12 MSTRG.16860.2_2 - 0.74 9.4 98.1 0.12 12.0 31.4 4.8 1 1 2 4 4 4 0 IncA protein T2SSF PF00482.21 MSTRG.16860.2_2 - 1.8 8.4 17.1 0.11 12.3 4.1 3.9 3 1 1 4 4 4 0 Type II secretion system (T2SS), protein F DUF1664 PF07889.10 MSTRG.16860.2_2 - 5.3 6.9 52.7 3 7.7 3.6 5.7 2 1 4 7 7 7 0 Protein of unknown function (DUF1664) Fez1 PF06818.13 MSTRG.16860.2_2 - 9.3 6.5 91.1 64 3.8 15.9 5.0 1 1 2 3 3 2 0 Fez1 ERM PF00769.17 MSTRG.16860.2_2 - 9.6 5.8 97.2 1.4 8.5 33.6 4.1 1 1 2 3 3 3 0 Ezrin/radixin/moesin family AIP3 PF03915.11 MSTRG.7137.2_1 - 8.1e-14 51.4 15.3 9.9e-08 31.3 0.0 3.9 3 1 0 3 3 3 3 Actin interacting protein 3 Synaptobrevin PF00957.19 MSTRG.16006.1_2 - 9.1e-29 99.0 0.7 1.6e-28 98.2 0.7 1.4 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.4 MSTRG.16006.1_2 - 2.9e-27 94.4 0.8 5.3e-27 93.5 0.8 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain Phospholamban PF04272.12 MSTRG.16006.1_2 - 0.012 14.9 1.7 0.012 14.9 1.7 1.9 2 0 0 2 2 2 0 Phospholamban DUF481 PF04338.10 MSTRG.16006.1_2 - 0.1 12.5 0.1 0.15 11.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF481 RRM_1 PF00076.20 MSTRG.5607.2_1 - 1.1e-14 53.9 0.2 5.4e-07 29.2 0.0 3.1 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 MSTRG.5607.2_1 - 0.01 15.3 0.1 0.98 8.9 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) VRR_NUC PF08774.9 MSTRG.25081.1_1 - 6.8e-27 93.5 0.1 1.5e-26 92.4 0.1 1.6 1 0 0 1 1 1 1 VRR-NUC domain TPR_2 PF07719.15 MSTRG.25081.1_1 - 0.075 13.1 1.8 4.2 7.6 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4363 PF14276.4 MSTRG.25081.1_1 - 0.22 11.4 0.5 0.51 10.3 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) TPR_12 PF13424.4 MSTRG.25081.1_1 - 0.32 11.2 5.5 2.5 8.3 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.25081.1_1 - 2.4 8.3 4.5 42 4.4 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat WD40 PF00400.30 MSTRG.13229.1_2 - 5.1e-05 23.8 0.8 0.0091 16.7 0.0 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat Xpo1 PF08389.10 MSTRG.18682.3_2 - 2e-21 76.5 17.9 1.1e-19 70.9 0.0 6.8 7 1 0 7 7 7 2 Exportin 1-like protein IBN_N PF03810.17 MSTRG.18682.3_2 - 9.3e-08 31.8 0.4 4e-07 29.7 0.1 2.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain DUF1280 PF06918.12 MSTRG.19334.1_3 - 0.16 11.4 0.2 0.22 10.9 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1280) KxDL PF10241.7 MSTRG.19334.1_3 - 0.26 11.4 2.1 1.5 9.0 1.9 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein AMP-binding PF00501.26 MSTRG.284.2_3 - 2.6e-67 227.1 0.0 3.2e-67 226.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 MSTRG.284.2_3 - 8.3e-06 26.6 0.0 1.5e-05 25.8 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Glyco_transf_41 PF13844.4 MSTRG.7497.1_3 - 4.4e-250 829.8 0.0 6.6e-250 829.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 41 TPR_1 PF00515.26 MSTRG.7497.1_3 - 4.6e-96 311.0 27.0 3.4e-10 39.2 0.3 13.1 13 0 0 13 13 13 11 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.7497.1_3 - 7.8e-91 297.4 32.5 1.2e-10 40.7 0.4 12.8 3 2 10 13 13 13 12 TPR repeat TPR_2 PF07719.15 MSTRG.7497.1_3 - 2.7e-72 233.0 27.0 3.3e-08 32.9 0.4 12.9 13 0 0 13 13 12 11 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.7497.1_3 - 3.1e-65 211.9 30.5 1.1e-05 25.3 0.2 13.4 13 0 0 13 13 13 12 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.7497.1_3 - 4.2e-65 210.5 12.7 1.4e-06 27.9 0.1 13.2 14 0 0 14 14 13 11 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.7497.1_3 - 1.4e-47 159.7 25.6 2.6e-11 43.5 0.3 9.2 7 2 2 9 9 9 6 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.7497.1_3 - 5.6e-45 148.0 13.9 0.0006 20.3 0.1 12.0 5 3 7 12 12 12 10 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.7497.1_3 - 1.6e-43 146.9 17.9 4.9e-07 30.0 0.5 9.1 4 4 5 9 9 9 9 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.7497.1_3 - 1.1e-42 144.3 8.9 2.8e-08 34.2 0.1 7.4 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.7497.1_3 - 3.2e-42 139.3 15.7 9.8e-05 22.0 0.1 12.9 13 1 0 13 13 13 8 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.7497.1_3 - 4.1e-39 131.3 44.7 7.3e-07 28.7 0.4 12.1 12 0 0 12 12 12 7 Tetratricopeptide repeat TPR_9 PF13371.4 MSTRG.7497.1_3 - 6.8e-17 61.3 13.2 0.0084 16.1 0.0 6.8 5 1 2 7 7 6 6 Tetratricopeptide repeat NARP1 PF12569.6 MSTRG.7497.1_3 - 5.2e-15 55.2 5.3 0.00073 18.4 0.0 5.5 1 1 3 5 5 5 4 NMDA receptor-regulated protein 1 TPR_6 PF13174.4 MSTRG.7497.1_3 - 1.8e-14 53.2 13.4 0.49 11.0 0.0 10.2 11 0 0 11 11 10 2 Tetratricopeptide repeat TPR_4 PF07721.12 MSTRG.7497.1_3 - 6.1e-13 47.9 6.9 2.1 9.1 0.3 9.1 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_15 PF13429.4 MSTRG.7497.1_3 - 8.2e-10 38.2 6.0 1.5e-05 24.2 0.8 4.5 1 1 2 5 5 5 2 Tetratricopeptide repeat FAT PF02259.21 MSTRG.7497.1_3 - 2.5e-08 33.4 0.0 0.82 8.7 0.0 5.6 2 2 2 4 4 4 2 FAT domain MIT PF04212.16 MSTRG.7497.1_3 - 2.1e-07 30.8 22.0 0.13 12.3 0.1 8.5 7 1 2 9 9 8 1 MIT (microtubule interacting and transport) domain TPR_21 PF09976.7 MSTRG.7497.1_3 - 4.7e-07 29.6 11.0 0.011 15.3 0.0 4.9 3 2 2 5 5 5 3 Tetratricopeptide repeat-like domain TPR_3 PF07720.10 MSTRG.7497.1_3 - 1e-06 28.5 0.3 1.6 8.7 0.0 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat Wzy_C_2 PF11846.6 MSTRG.7497.1_3 - 7.7e-06 25.8 6.3 0.0051 16.6 0.4 4.3 3 1 2 5 5 5 1 Virulence factor membrane-bound polymerase, C-terminal SNAP PF14938.4 MSTRG.7497.1_3 - 0.0002 20.8 15.6 0.023 14.0 3.9 4.3 1 1 2 4 4 4 2 Soluble NSF attachment protein, SNAP SHNi-TPR PF10516.7 MSTRG.7497.1_3 - 0.00072 18.8 1.8 16 4.9 0.0 5.4 7 0 0 7 7 6 0 SHNi-TPR BTAD PF03704.15 MSTRG.7497.1_3 - 0.0012 19.2 12.7 0.88 9.9 0.7 4.7 2 2 2 4 4 4 2 Bacterial transcriptional activator domain RPN7 PF10602.7 MSTRG.7497.1_3 - 0.0012 18.4 10.9 24 4.4 0.1 7.7 6 2 4 10 10 10 0 26S proteasome subunit RPN7 TPR_5 PF12688.5 MSTRG.7497.1_3 - 0.015 15.4 1.4 1.8 8.7 0.1 3.7 3 1 1 4 4 3 0 Tetratrico peptide repeat Mad3_BUB1_I PF08311.10 MSTRG.7497.1_3 - 0.016 15.0 4.2 47 3.9 0.0 5.9 4 1 2 6 6 6 0 Mad3/BUB1 homology region 1 Tcf25 PF04910.12 MSTRG.7497.1_3 - 0.024 13.6 0.2 0.077 11.9 0.0 1.9 2 0 0 2 2 2 0 Transcriptional repressor TCF25 Alkyl_sulf_dimr PF14863.4 MSTRG.7497.1_3 - 0.039 14.3 0.8 8.4 6.7 0.2 2.9 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation PPR PF01535.18 MSTRG.7497.1_3 - 0.051 13.7 5.7 40 4.6 0.1 6.4 8 0 0 8 8 5 0 PPR repeat EST1_DNA_bind PF10373.7 MSTRG.7497.1_3 - 0.058 12.7 14.3 1.5 8.1 0.2 4.6 5 1 1 6 6 6 0 Est1 DNA/RNA binding domain TOM20_plant PF06552.10 MSTRG.7497.1_3 - 0.18 11.4 0.3 51 3.4 0.0 3.6 2 1 2 4 4 4 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_20 PF14561.4 MSTRG.7497.1_3 - 0.33 11.2 11.9 2.1 8.6 0.1 5.4 4 2 3 8 8 6 0 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.7497.1_3 - 0.33 11.0 19.8 0.018 15.1 1.4 5.0 4 2 2 6 6 5 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF627 PF04781.10 MSTRG.7497.1_3 - 0.35 10.8 3.9 7.5 6.5 0.0 4.4 2 1 2 4 4 4 0 Protein of unknown function (DUF627) eIF-1a PF01176.17 MSTRG.29024.1_3 - 0.042 13.5 0.5 7.9 6.2 0.1 2.1 2 0 0 2 2 2 0 Translation initiation factor 1A / IF-1 UPA PF17217.1 MSTRG.7423.1_1 - 7e-42 142.7 0.0 1e-41 142.1 0.0 1.2 1 0 0 1 1 1 1 UPA domain Death PF00531.20 MSTRG.7423.1_1 - 4.5e-11 42.6 0.0 6.8e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 Death domain CobS PF02654.13 MSTRG.7423.1_2 - 0.095 12.7 0.1 0.17 11.9 0.1 1.3 1 0 0 1 1 1 0 Cobalamin-5-phosphate synthase NPR2 PF06218.9 MSTRG.26968.2_1 - 2.2e-79 267.1 3.6 2.1e-61 207.9 4.2 2.6 1 1 1 2 2 2 2 Nitrogen permease regulator 2 HTH_Tnp_Tc3_2 PF01498.16 MSTRG.21451.1_1 - 1.1e-05 25.4 0.6 1.9e-05 24.7 0.6 1.4 1 0 0 1 1 1 1 Transposase WD40 PF00400.30 MSTRG.21451.1_1 - 0.052 14.3 0.2 0.087 13.6 0.2 1.4 1 0 0 1 1 1 0 WD domain, G-beta repeat RhoGAP PF00620.25 MSTRG.26977.1_2 - 6.3e-39 133.1 0.7 1.1e-38 132.3 0.7 1.3 1 0 0 1 1 1 1 RhoGAP domain PEHE PF15275.4 MSTRG.26977.1_2 - 9 6.8 9.3 4.5 7.8 5.4 2.4 2 0 0 2 2 2 0 PEHE domain LIM PF00412.20 MSTRG.3051.2_2 - 6.3e-24 83.8 23.8 4.5e-13 49.1 11.2 2.2 2 0 0 2 2 2 2 LIM domain PDZ PF00595.22 MSTRG.3051.2_2 - 3e-12 46.6 0.3 4.7e-12 45.9 0.3 1.2 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.3051.2_2 - 0.041 14.1 0.1 0.077 13.2 0.1 1.4 1 0 0 1 1 1 0 PDZ domain RasGEF PF00617.17 MSTRG.25634.1_2 - 8.1e-52 175.7 1.9 1e-51 175.4 0.8 1.8 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.18 MSTRG.25634.1_2 - 7.7e-13 48.5 0.2 2.2e-12 47.0 0.2 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif BTAD PF03704.15 MSTRG.25634.1_2 - 0.062 13.6 0.9 0.1 12.9 0.9 1.3 1 0 0 1 1 1 0 Bacterial transcriptional activator domain TPR_14 PF13428.4 MSTRG.25634.1_2 - 0.08 13.7 0.5 0.25 12.1 0.5 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Trypsin PF00089.24 MSTRG.1893.7_2 - 9.2e-63 211.9 0.1 1e-62 211.7 0.1 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 MSTRG.1893.7_2 - 8.6e-11 42.8 0.0 1.2e-10 42.3 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 MSTRG.1893.7_2 - 0.0018 18.5 0.0 0.0036 17.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Pico_P2A PF00947.17 MSTRG.1893.7_2 - 0.29 11.0 2.9 3 7.8 2.3 2.6 2 1 0 2 2 2 0 Picornavirus core protein 2A RHD_DNA_bind PF00554.20 MSTRG.512.2_1 - 8e-24 84.3 1.4 3.2e-23 82.4 1.4 1.8 1 1 0 1 1 1 1 Rel homology DNA-binding domain STAT_bind PF02864.13 MSTRG.21091.1_1 - 7.8e-58 196.2 6.1 2e-57 194.8 1.8 2.3 2 0 0 2 2 2 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 MSTRG.21091.1_1 - 3.9e-52 176.6 16.6 9e-52 175.4 16.6 1.7 1 0 0 1 1 1 1 STAT protein, all-alpha domain STAT_int PF02865.15 MSTRG.21091.1_1 - 1.2e-42 145.1 1.1 1.2e-42 145.1 1.1 3.2 3 0 0 3 3 3 1 STAT protein, protein interaction domain PrgH PF09480.8 MSTRG.21091.1_1 - 0.045 12.8 4.3 0.1 11.7 4.3 1.5 1 0 0 1 1 1 0 Type III secretion system protein PrgH-EprH (PrgH) GKAP PF03359.11 MSTRG.20332.2_2 - 1.9e-138 461.6 6.4 1.9e-138 461.6 6.4 1.8 2 0 0 2 2 2 1 Guanylate-kinase-associated protein (GKAP) protein CENP-F_leu_zip PF10473.7 MSTRG.9484.1_2 - 0.00012 22.0 54.7 0.031 14.2 12.7 4.1 3 1 0 3 3 3 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.9 MSTRG.9484.1_2 - 0.00015 21.9 22.3 0.00015 21.9 22.3 3.9 2 2 1 3 3 3 1 Autophagy protein 16 (ATG16) DivIC PF04977.13 MSTRG.9484.1_2 - 0.019 14.6 0.2 0.019 14.6 0.2 6.2 5 3 1 6 6 6 0 Septum formation initiator DUF4051 PF13260.4 MSTRG.9484.1_2 - 0.05 13.3 0.5 1.4 8.6 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4051) DUF3972 PF13118.4 MSTRG.9484.1_2 - 0.36 11.2 12.4 0.69 10.2 0.2 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF3972) SNF2_N PF00176.21 MSTRG.3152.1_2 - 2.3e-49 167.9 0.0 5.3e-49 166.7 0.0 1.4 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.29 MSTRG.3152.1_2 - 1e-13 51.5 0.0 2.3e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.3152.1_2 - 2.7e-07 30.6 0.0 7.7e-07 29.1 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.3 MSTRG.3152.1_2 - 0.00068 18.8 0.0 0.89 8.6 0.0 2.4 1 1 1 2 2 2 2 ERCC3/RAD25/XPB C-terminal helicase CX9C PF16860.3 MSTRG.298.5_2 - 2e-24 85.2 10.9 1.7e-17 63.0 2.4 2.4 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, NDUF_B7 PF05676.11 MSTRG.298.5_2 - 0.006 16.2 0.4 0.006 16.2 0.4 2.4 1 1 1 2 2 2 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) CHCH PF06747.11 MSTRG.298.5_2 - 0.0077 16.2 11.1 0.2 11.7 2.2 2.7 2 0 0 2 2 2 2 CHCH domain Cmc1 PF08583.8 MSTRG.298.5_2 - 0.12 12.2 12.3 1.1 9.2 5.7 3.1 1 1 2 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like Pet191_N PF10203.7 MSTRG.298.5_2 - 0.29 11.3 10.8 2.3 8.5 8.9 2.7 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 COX6B PF02297.15 MSTRG.298.5_2 - 7.8 6.7 10.8 19 5.4 1.8 2.3 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb GCK PF07802.9 MSTRG.298.5_2 - 9 6.7 11.0 3.5 8.0 1.1 2.6 2 1 1 3 3 3 0 GCK domain V-set PF07686.15 MSTRG.18067.1_2 - 3.2e-07 30.4 0.0 4.8e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain DUF843 PF05814.9 MSTRG.18067.1_2 - 0.0022 17.8 0.2 0.0048 16.8 0.2 1.4 1 0 0 1 1 1 1 Baculovirus protein of unknown function (DUF843) Ig_3 PF13927.4 MSTRG.18067.1_2 - 0.056 13.9 0.0 0.1 13.1 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain I-set PF07679.14 MSTRG.18067.1_2 - 0.088 12.8 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain ig PF00047.23 MSTRG.18067.1_2 - 0.1 12.6 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin domain EF-hand_7 PF13499.4 MSTRG.9014.2_3 - 3.6e-21 75.3 7.4 3.9e-21 75.2 0.6 3.3 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.9014.2_3 - 3.2e-05 23.1 0.0 0.00077 18.7 0.0 2.7 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.4 MSTRG.9014.2_3 - 0.0021 17.7 0.9 0.029 14.1 0.0 3.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.30 MSTRG.9014.2_3 - 0.0025 17.1 0.9 0.099 12.1 0.1 3.7 4 0 0 4 4 4 1 EF hand SPARC_Ca_bdg PF10591.7 MSTRG.9014.2_3 - 0.11 12.7 1.6 5.4 7.2 0.2 2.4 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region RasGEF PF00617.17 MSTRG.19296.1_3 - 8.2e-12 45.5 0.0 1.1e-11 45.1 0.0 1.2 1 0 0 1 1 1 1 RasGEF domain DUF4035 PF13227.4 MSTRG.15128.1_1 - 0.18 11.4 0.1 0.42 10.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4035) Synaphin PF05835.10 MSTRG.15128.1_2 - 4.2e-45 153.4 9.3 5.8e-45 152.9 9.3 1.2 1 0 0 1 1 1 1 Synaphin protein Cortexin PF11057.6 MSTRG.15128.1_2 - 0.65 9.7 4.4 1.4 8.7 4.4 1.5 1 0 0 1 1 1 0 Cortexin of kidney Peptidase_M28 PF04389.15 MSTRG.16879.2_2 - 8.7e-18 64.6 0.0 1.3e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.20 MSTRG.16879.2_2 - 2.6e-08 33.7 0.0 5.3e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 PA domain Kazal_1 PF00050.19 MSTRG.11474.1_1 - 3.4e-16 58.8 4.0 6.6e-16 57.9 4.0 1.5 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.13 MSTRG.11474.1_1 - 2.9e-09 36.8 4.6 5.4e-09 36.0 4.6 1.5 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Peptidase_M16 PF00675.18 MSTRG.15197.2_2 - 3.7e-55 185.9 0.1 5.4e-55 185.3 0.1 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.19 MSTRG.15197.2_2 - 1.9e-35 122.4 0.0 8.7e-35 120.2 0.0 1.9 2 0 0 2 2 2 1 Peptidase M16 inactive domain FHA PF00498.24 MSTRG.3904.1_1 - 0.0015 18.7 0.0 0.0033 17.6 0.0 1.7 1 0 0 1 1 1 1 FHA domain DUF3584 PF12128.6 MSTRG.3904.1_1 - 0.0049 14.3 25.4 0.028 11.8 14.9 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3584) HSBP1 PF06825.10 MSTRG.3904.1_1 - 0.043 13.6 0.4 0.043 13.6 0.4 1.7 2 0 0 2 2 2 0 Heat shock factor binding protein 1 DUF4988 PF16378.3 MSTRG.3904.1_1 - 0.2 11.1 1.2 0.36 10.2 1.2 1.4 1 0 0 1 1 1 0 Domain of unknown function Seryl_tRNA_N PF02403.20 MSTRG.3904.1_1 - 0.28 11.3 13.1 0.45 10.6 11.8 2.0 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain CorA PF01544.16 MSTRG.3904.1_1 - 4.3 6.4 8.9 7.5 5.6 8.9 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF1664 PF07889.10 MSTRG.3904.1_1 - 5.5 6.9 7.5 12 5.8 7.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Conotoxin PF02950.15 MSTRG.3904.1_2 - 0.2 12.6 2.3 0.52 11.2 2.3 1.7 1 0 0 1 1 1 0 Conotoxin EB1 PF03271.15 MSTRG.19894.1_3 - 3.3e-17 62.3 0.7 3.3e-17 62.3 0.7 2.4 2 0 0 2 2 2 1 EB1-like C-terminal motif CH PF00307.29 MSTRG.19894.1_3 - 2.1e-11 43.8 1.3 3.5e-11 43.1 0.4 1.8 2 0 0 2 2 2 1 Calponin homology (CH) domain Herpes_gI PF01688.15 MSTRG.19894.1_3 - 0.054 13.3 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein I CAMSAP_CH PF11971.6 MSTRG.19894.1_3 - 0.092 12.5 0.1 0.2 11.4 0.1 1.5 1 0 0 1 1 1 0 CAMSAP CH domain Kelch_1 PF01344.23 MSTRG.27982.2_1 - 7e-24 83.0 8.3 1e-05 24.9 0.0 6.5 6 0 0 6 6 6 5 Kelch motif Lectin_C PF00059.19 MSTRG.27982.2_1 - 1e-19 71.1 0.0 1e-19 71.1 0.0 2.8 2 1 0 2 2 1 1 Lectin C-type domain Kelch_3 PF13415.4 MSTRG.27982.2_1 - 3.5e-18 65.3 10.8 0.00018 21.6 0.0 6.6 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_4 PF13418.4 MSTRG.27982.2_1 - 4.4e-16 58.4 8.6 0.0011 18.7 0.0 6.1 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.4 MSTRG.27982.2_1 - 9.9e-16 57.2 21.1 1.5e-05 24.7 0.1 6.3 7 0 0 7 7 6 5 Kelch motif Kelch_6 PF13964.4 MSTRG.27982.2_1 - 1.4e-15 56.8 9.7 2.9e-08 33.6 0.1 6.4 6 0 0 6 6 6 3 Kelch motif CUB PF00431.18 MSTRG.27982.2_1 - 6.5e-14 52.1 0.0 1.3e-13 51.1 0.0 1.5 1 0 0 1 1 1 1 CUB domain PSI PF01437.23 MSTRG.27982.2_1 - 1e-13 51.4 25.7 3.4e-12 46.6 6.2 7.5 7 2 0 7 7 4 4 Plexin repeat Kelch_2 PF07646.13 MSTRG.27982.2_1 - 1.5e-13 50.0 8.7 0.00072 19.3 0.1 6.2 5 0 0 5 5 5 3 Kelch motif PSI_integrin PF17205.1 MSTRG.27982.2_1 - 0.00017 21.2 5.0 0.00017 21.2 5.0 6.2 5 1 0 5 5 4 2 Integrin plexin domain Laminin_EGF PF00053.22 MSTRG.27982.2_1 - 0.00024 21.0 16.0 0.00024 21.0 16.0 9.0 8 2 1 9 9 6 3 Laminin EGF domain EGF_2 PF07974.11 MSTRG.27982.2_1 - 0.0017 18.6 28.9 0.0041 17.3 10.0 9.6 8 2 0 8 8 4 3 EGF-like domain EGF PF00008.25 MSTRG.27982.2_1 - 0.01 16.0 5.6 0.01 16.0 5.6 7.6 9 0 0 9 9 4 1 EGF-like domain ATP-gua_Ptrans PF00217.17 MSTRG.11141.1_3 - 2.2e-57 194.4 0.0 2.7e-57 194.1 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.13 MSTRG.11141.1_3 - 7.6e-13 48.5 0.0 1.6e-12 47.5 0.0 1.6 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain DUF4533 PF15047.4 MSTRG.11141.1_3 - 0.046 13.3 0.1 0.075 12.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4533) P5CR_dimer PF14748.4 MSTRG.9282.2_3 - 6.4e-37 125.8 1.9 8.9e-37 125.3 0.1 2.3 3 0 0 3 3 3 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.15 MSTRG.9282.2_3 - 2.8e-19 69.3 0.1 6.4e-19 68.2 0.1 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Rossmann-like PF10727.7 MSTRG.9282.2_3 - 0.00022 21.0 1.1 0.00053 19.7 1.1 1.6 1 0 0 1 1 1 1 Rossmann-like domain NAD_Gly3P_dh_N PF01210.21 MSTRG.9282.2_3 - 0.0023 17.8 0.1 0.0039 17.0 0.1 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.14 MSTRG.9282.2_3 - 0.0076 15.8 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA OCD_Mu_crystall PF02423.13 MSTRG.9282.2_3 - 0.015 14.1 0.1 0.045 12.6 0.1 1.8 2 0 0 2 2 2 0 Ornithine cyclodeaminase/mu-crystallin family 2-Hacid_dh_C PF02826.17 MSTRG.9282.2_3 - 0.044 13.0 0.0 0.2 10.8 0.0 1.9 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain tRNA-synt_2c PF01411.17 MSTRG.18415.1_1 - 2.4e-220 732.6 0.0 3.9e-220 731.9 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.12 MSTRG.18415.1_1 - 3.2e-15 55.8 0.0 6.9e-15 54.7 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.17 MSTRG.18415.1_1 - 4.8e-11 42.4 0.0 1.3e-10 41.1 0.0 1.7 1 0 0 1 1 1 1 DHHA1 domain Ig_3 PF13927.4 MSTRG.17171.2_1 - 0.00058 20.3 0.2 0.0012 19.3 0.2 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Izumo-Ig PF16706.3 MSTRG.17171.2_1 - 0.012 15.5 0.1 0.018 14.9 0.1 1.3 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain ig PF00047.23 MSTRG.17171.2_1 - 0.021 14.8 0.2 0.036 14.1 0.2 1.3 1 0 0 1 1 1 0 Immunoglobulin domain Ribosomal_L1 PF00687.19 MSTRG.3492.1_3 - 3.5e-47 160.6 0.4 3.5e-47 160.6 0.4 1.6 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family CRAL_TRIO PF00650.18 MSTRG.19167.1_1 - 7.5e-28 97.1 0.0 1.1e-27 96.5 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain UBA PF00627.29 MSTRG.3038.2_2 - 0.0012 18.6 0.0 0.0022 17.7 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain Rhomboid PF01694.20 MSTRG.3038.2_2 - 0.01 15.7 2.1 0.018 14.9 2.1 1.3 1 0 0 1 1 1 0 Rhomboid family Requiem_N PF14051.4 MSTRG.15838.2_2 - 1.1e-32 111.9 1.2 2.1e-32 111.0 1.2 1.5 1 0 0 1 1 1 1 N-terminal domain of DPF2/REQ. PHD PF00628.27 MSTRG.15838.2_2 - 8.6e-18 63.8 34.8 2.2e-11 43.3 7.6 4.4 3 1 1 4 4 4 2 PHD-finger zf-PHD-like PF15446.4 MSTRG.15838.2_2 - 0.87 9.0 15.4 0.16 11.5 2.1 3.5 2 1 0 3 3 3 0 PHD/FYVE-zinc-finger like domain PBP1_TM PF14812.4 MSTRG.15838.2_2 - 4.3 7.7 8.7 1.1 9.6 4.8 1.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Mtc1 PF10310.7 MSTRG.15838.2_2 - 8.2 5.1 6.5 12 4.6 6.5 1.1 1 0 0 1 1 1 0 Maintenance of telomere capping protein 1 Methyltransf_25 PF13649.4 MSTRG.29578.1_3 - 1.4e-09 38.4 0.0 2.4e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 MSTRG.29578.1_3 - 1.1e-07 32.3 0.0 1.8e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 MSTRG.29578.1_3 - 2.2e-07 30.6 0.0 2.9e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 MSTRG.29578.1_3 - 2.5e-06 28.0 0.0 5.7e-06 26.9 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain MTS PF05175.12 MSTRG.29578.1_3 - 2.5e-05 23.8 0.0 3.9e-05 23.1 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.4 MSTRG.29578.1_3 - 0.0012 18.7 0.0 0.0017 18.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 MSTRG.29578.1_3 - 0.044 13.6 0.0 0.054 13.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Yip1 PF04893.15 MSTRG.14583.1_2 - 4.3e-10 39.4 20.1 9.6e-10 38.3 19.4 1.9 1 1 1 2 2 2 1 Yip1 domain ACTH_assoc PF16102.3 MSTRG.7618.2_1 - 0.13 13.0 0.5 0.27 12.0 0.5 1.5 1 0 0 1 1 1 0 ACTH-associated domain Sushi PF00084.18 MSTRG.7618.2_2 - 3.1e-36 123.6 31.6 9.3e-11 42.1 1.8 4.5 4 0 0 4 4 4 4 Sushi repeat (SCR repeat) cEGF PF12662.5 MSTRG.7618.2_2 - 6.3 6.7 18.8 3.2 7.6 1.4 4.5 4 1 0 4 4 4 0 Complement Clr-like EGF-like DUF843 PF05814.9 MSTRG.7618.2_3 - 0.4 10.6 3.0 0.7 9.8 3.0 1.3 1 0 0 1 1 1 0 Baculovirus protein of unknown function (DUF843) Nab1 PF04902.10 MSTRG.11790.1_3 - 4.1e-84 281.4 8.8 6.9e-84 280.6 8.8 1.4 1 0 0 1 1 1 1 Conserved region in Nab1 NCD2 PF04905.11 MSTRG.11790.1_3 - 1.8e-62 209.8 0.1 3.5e-62 208.9 0.1 1.4 1 0 0 1 1 1 1 NAB conserved region 2 (NCD2) NCD1 PF04904.11 MSTRG.11790.1_3 - 2.6e-41 139.4 0.1 4.8e-41 138.5 0.1 1.5 1 0 0 1 1 1 1 NAB conserved region 1 (NCD1) ATG_C PF09333.9 MSTRG.11790.1_3 - 0.17 12.1 0.1 0.97 9.7 0.0 2.1 2 0 0 2 2 2 0 Autophagy-related protein C terminal domain Ank_5 PF13857.4 MSTRG.15233.5_3 - 2.4e-07 30.8 0.0 5e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.4 MSTRG.15233.5_3 - 2.6e-06 27.7 0.0 6.9e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.15233.5_3 - 0.00044 20.4 0.0 0.0011 19.1 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeat Ank PF00023.28 MSTRG.15233.5_3 - 0.00059 20.1 0.0 0.002 18.4 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.5 MSTRG.15233.5_3 - 0.00074 19.9 0.0 0.0014 19.1 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) HRM PF02793.20 MSTRG.19393.1_3 - 5.2e-11 42.6 5.9 1.4e-10 41.2 5.9 1.8 1 0 0 1 1 1 1 Hormone receptor domain Lin-8 PF03353.13 MSTRG.4820.2_2 - 2.9 7.3 10.0 3.7 6.9 10.0 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Adaptin_N PF01602.18 MSTRG.25063.1_2 - 6.9e-75 252.4 9.9 8.2e-75 252.2 9.9 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.5 MSTRG.25063.1_2 - 8.7e-07 28.9 0.2 7.8e-06 25.8 0.0 2.5 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.4 MSTRG.25063.1_2 - 0.0014 18.9 0.0 1.1 9.7 0.0 4.8 6 0 0 6 6 6 1 HEAT-like repeat HEAT PF02985.20 MSTRG.25063.1_2 - 0.002 18.0 0.0 0.61 10.3 0.0 4.2 4 0 0 4 4 4 1 HEAT repeat HEAT_2 PF13646.4 MSTRG.25063.1_2 - 0.067 13.5 0.0 1.8 8.8 0.0 3.1 3 2 0 3 3 3 0 HEAT repeats DEAD PF00270.27 MSTRG.7557.1_3 - 5.3e-38 130.4 0.0 1.1e-37 129.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.7557.1_3 - 6.8e-26 90.7 1.3 3.2e-25 88.5 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DsrH PF04077.10 MSTRG.7557.1_3 - 0.13 12.3 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 DsrH like protein Peptidase_S8 PF00082.20 MSTRG.22011.1_1 - 5.3e-39 134.1 0.0 7.6e-39 133.6 0.0 1.2 1 0 0 1 1 1 1 Subtilase family ABC_transp_aux PF09822.7 MSTRG.22011.1_1 - 0.074 12.4 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 ABC-type uncharacterized transport system Ribosomal_L7Ae PF01248.24 MSTRG.16454.4_1 - 5e-29 99.8 1.6 6.6e-29 99.4 1.6 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Hormone_recep PF00104.28 MSTRG.22038.1_1 - 1.9e-15 56.9 0.7 4.6e-15 55.6 0.7 1.5 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor GSHPx PF00255.17 MSTRG.6669.1_2 - 4.6e-37 125.8 0.2 6.2e-37 125.4 0.2 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.19 MSTRG.6669.1_2 - 6.2e-05 22.8 0.0 0.00024 20.9 0.0 1.9 1 1 0 1 1 1 1 AhpC/TSA family SCO1-SenC PF02630.12 MSTRG.6669.1_2 - 0.014 15.1 0.0 1.4 8.6 0.0 2.3 2 0 0 2 2 2 0 SCO1/SenC PepSY PF03413.17 MSTRG.6669.1_2 - 0.068 13.6 0.1 0.11 12.9 0.1 1.5 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain zf-CCCH PF00642.22 MSTRG.20143.1_1 - 1.3e-06 28.0 6.0 2.6e-06 27.1 6.0 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.20 MSTRG.20143.1_1 - 2.8e-05 23.7 0.0 4.7e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 MSTRG.20143.1_1 - 0.15 11.9 0.1 0.28 11.0 0.1 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif zf-CCCH PF00642.22 MSTRG.20143.1_2 - 1e-06 28.4 2.6 1e-06 28.4 2.6 1.8 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.3 MSTRG.20143.1_2 - 0.024 15.2 0.1 0.045 14.3 0.1 1.3 1 0 0 1 1 1 0 Torus domain DBB PF14545.4 MSTRG.8994.1_1 - 0.15 11.9 0.0 0.26 11.1 0.0 1.3 1 0 0 1 1 1 0 Dof, BCAP, and BANK (DBB) motif, PPARgamma_N PF12577.6 MSTRG.21045.2_2 - 1.1e-31 109.2 2.8 2.7e-31 107.9 2.8 1.7 1 0 0 1 1 1 1 PPAR gamma N-terminal region zf-C4 PF00105.16 MSTRG.21045.2_2 - 9.3e-27 93.2 15.4 9.3e-27 93.2 15.4 1.9 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 MSTRG.21045.2_2 - 1.8e-16 60.2 1.2 3.6e-16 59.2 1.2 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Band_7 PF01145.23 MSTRG.7642.2_2 - 3.4e-16 59.6 0.6 5.1e-16 59.1 0.1 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family DUF4346 PF14251.4 MSTRG.7642.2_2 - 0.057 13.3 2.5 0.097 12.6 2.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4346) Pkinase PF00069.23 MSTRG.27063.1_3 - 1.1e-73 247.7 0.0 1.6e-73 247.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.27063.1_3 - 7e-47 159.8 0.0 1.1e-46 159.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 MSTRG.27063.1_3 - 6.1e-24 84.1 0.0 1.3e-23 83.0 0.0 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 MSTRG.27063.1_3 - 1.8e-07 30.6 0.1 0.00047 19.4 0.0 2.3 1 1 1 2 2 2 2 Kinase-like APH PF01636.21 MSTRG.27063.1_3 - 0.0094 15.8 0.0 0.16 11.7 0.1 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.12 MSTRG.27063.1_3 - 0.038 13.2 0.0 0.071 12.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EloA-BP1 PF15870.3 MSTRG.16828.3_1 - 4.6e-29 101.7 3.1 4.6e-29 101.7 3.1 2.8 2 1 0 2 2 2 1 ElonginA binding-protein 1 Omega-toxin PF06357.9 MSTRG.16828.3_1 - 0.054 13.2 4.3 0.17 11.6 0.4 2.7 2 0 0 2 2 2 0 Omega-atracotoxin KIX_2 PF16987.3 MSTRG.16828.3_1 - 0.09 12.7 0.9 0.25 11.2 0.9 1.7 1 0 0 1 1 1 0 KIX domain Spt5_N PF11942.6 MSTRG.16828.3_1 - 1.5 9.7 5.5 9.3 7.2 0.1 3.0 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal MADF_DNA_bdg PF10545.7 MSTRG.14883.1_1 - 0.0043 17.2 0.5 0.13 12.5 0.0 2.3 2 0 0 2 2 2 2 Alcohol dehydrogenase transcription factor Myb/SANT-like G8 PF10162.7 MSTRG.9935.1_2 - 1.5e-30 105.7 0.0 5.6e-30 103.8 0.0 2.0 2 0 0 2 2 2 1 G8 domain Beta_helix PF13229.4 MSTRG.9935.1_2 - 5.1e-11 42.5 3.3 0.00019 21.2 1.3 3.5 3 0 0 3 3 3 2 Right handed beta helix region 1-cysPrx_C PF10417.7 MSTRG.9935.1_2 - 0.2 11.4 3.0 0.61 9.9 0.1 2.6 2 0 0 2 2 2 0 C-terminal domain of 1-Cys peroxiredoxin EF-hand_7 PF13499.4 MSTRG.19411.1_1 - 7.9e-11 42.1 1.3 1.3e-10 41.5 1.3 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 MSTRG.19411.1_1 - 3.5e-10 38.5 4.0 0.00012 21.3 1.3 2.4 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.4 MSTRG.19411.1_1 - 2.1e-08 33.2 4.5 0.00084 18.6 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 MSTRG.19411.1_1 - 5e-08 32.1 3.2 0.0002 20.9 0.6 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.4 MSTRG.19411.1_1 - 4.8e-06 26.1 0.7 1e-05 25.0 0.2 1.8 1 1 1 2 2 2 1 EF-hand domain pair Gal-bind_lectin PF00337.20 MSTRG.23409.2_3 - 4.1e-20 71.5 0.0 5.5e-20 71.1 0.0 1.1 1 0 0 1 1 1 1 Galactoside-binding lectin Cullin PF00888.20 MSTRG.22006.3_1 - 7.1e-199 662.2 17.8 7.1e-199 662.2 17.8 1.6 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.7 MSTRG.22006.3_1 - 2.1e-28 98.0 3.9 8.4e-28 96.1 3.0 2.4 2 0 0 2 2 2 1 Cullin protein neddylation domain Acyltransferase PF01553.19 MSTRG.8315.2_1 - 1.6e-18 66.5 0.0 2.9e-18 65.6 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase Sushi PF00084.18 MSTRG.20436.2_2 - 2.7e-38 130.3 9.8 1.3e-10 41.6 0.4 4.4 4 0 0 4 4 4 4 Sushi repeat (SCR repeat) DUF1690 PF07956.9 MSTRG.9608.1_1 - 0.02 15.2 0.3 0.03 14.6 0.3 1.2 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) Sds3 PF08598.9 MSTRG.9608.1_1 - 0.02 14.8 0.4 0.028 14.3 0.4 1.2 1 0 0 1 1 1 0 Sds3-like Condensin2nSMC PF12422.6 MSTRG.9608.1_1 - 0.12 12.4 0.9 0.18 11.9 0.9 1.2 1 0 0 1 1 1 0 Condensin II non structural maintenance of chromosomes subunit DUF2052 PF09747.7 MSTRG.11865.1_3 - 2.9e-45 154.7 25.2 7e-44 150.2 25.2 2.2 1 1 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) INCENP_ARK-bind PF03941.13 MSTRG.25027.1_2 - 6.8e-20 70.6 1.7 1.6e-19 69.4 1.7 1.7 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region INCENP_N PF12178.6 MSTRG.25027.1_3 - 3.4e-17 61.9 0.7 8.4e-17 60.7 0.7 1.7 1 0 0 1 1 1 1 Chromosome passenger complex (CPC) protein INCENP N terminal Ras PF00071.20 MSTRG.6493.1_2 - 1.2e-43 148.3 0.0 1.8e-43 147.8 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.6493.1_2 - 2.4e-18 66.4 0.0 3.7e-18 65.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.6493.1_2 - 1.8e-05 24.1 0.0 2.8e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 MSTRG.6493.1_2 - 0.089 12.1 0.0 0.2 10.9 0.0 1.6 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit DUF2650 PF10853.6 MSTRG.506.1_1 - 2.1 8.1 7.7 4.5 7.0 1.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2650) BTB PF00651.29 MSTRG.19679.1_1 - 7.2e-22 77.6 0.3 1.3e-21 76.7 0.3 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_5 PF13909.4 MSTRG.19679.1_1 - 7e-08 31.9 1.4 7e-08 31.9 1.4 4.0 4 0 0 4 4 4 1 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.4 MSTRG.19679.1_1 - 2.2e-06 27.7 15.1 0.016 15.5 0.1 5.2 4 0 0 4 4 4 2 Zinc-finger double domain DUF3342 PF11822.6 MSTRG.19679.1_1 - 0.00012 22.1 0.1 0.00027 20.9 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) zf-C2H2 PF00096.24 MSTRG.19679.1_1 - 0.49 10.8 29.7 0.032 14.5 1.9 5.9 4 1 0 4 4 4 0 Zinc finger, C2H2 type bZIP_1 PF00170.19 MSTRG.14084.1_1 - 7.6e-11 41.8 5.2 1.2e-10 41.1 5.2 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 MSTRG.14084.1_1 - 1.9e-06 27.7 5.9 1.9e-06 27.7 5.9 1.9 2 0 0 2 2 2 1 Basic region leucine zipper zf-C2H2 PF00096.24 MSTRG.14084.1_1 - 0.076 13.4 7.2 0.096 13.1 1.8 3.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type bZIP_Maf PF03131.15 MSTRG.14084.1_1 - 2.3 8.7 12.5 0.024 15.0 3.2 2.1 2 0 0 2 2 2 0 bZIP Maf transcription factor La PF05383.15 MSTRG.14084.1_2 - 5.6e-14 51.8 0.2 5.6e-14 51.8 0.2 1.7 2 0 0 2 2 2 1 La domain RRM_1 PF00076.20 MSTRG.8902.1_2 - 3.6e-33 113.1 0.2 2.2e-16 59.3 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 MSTRG.8902.1_2 - 1.5e-06 28.1 0.2 7.2e-05 22.6 0.0 2.3 2 0 0 2 2 2 1 RNA binding motif RRM_occluded PF16842.3 MSTRG.8902.1_2 - 0.0001 21.9 0.0 0.048 13.4 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_5 PF13893.4 MSTRG.8902.1_2 - 0.00015 21.3 0.0 0.13 11.7 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 MSTRG.8902.1_2 - 0.004 16.9 0.0 0.037 13.9 0.0 2.1 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif CDC45 PF02724.12 MSTRG.8902.1_2 - 0.018 13.3 10.4 0.023 12.9 10.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DbpA PF03880.13 MSTRG.8902.1_2 - 0.072 13.0 0.1 11 6.0 0.0 2.4 2 0 0 2 2 2 0 DbpA RNA binding domain Myosin_tail_1 PF01576.17 MSTRG.15733.1_2 - 6.2e-27 93.7 54.6 6.9e-27 93.6 54.6 1.0 1 0 0 1 1 1 1 Myosin tail IncA PF04156.12 MSTRG.15733.1_2 - 0.0019 17.9 49.4 0.054 13.2 17.0 3.1 1 1 2 3 3 3 2 IncA protein Tropomyosin PF00261.18 MSTRG.15733.1_2 - 0.0099 15.1 50.2 0.24 10.6 34.7 2.8 1 1 1 2 2 2 2 Tropomyosin Fib_alpha PF08702.8 MSTRG.15733.1_2 - 0.011 15.8 32.4 0.09 12.8 16.3 2.7 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Laminin_II PF06009.10 MSTRG.15733.1_2 - 0.072 13.0 36.5 0.85 9.5 10.6 3.1 1 1 2 3 3 3 0 Laminin Domain II Filament PF00038.19 MSTRG.15733.1_2 - 0.17 11.3 44.8 0.085 12.3 33.9 2.5 1 1 0 1 1 1 0 Intermediate filament protein Reo_sigmaC PF04582.10 MSTRG.15733.1_2 - 0.18 11.0 14.2 0.045 13.0 5.9 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein ERM PF00769.17 MSTRG.15733.1_2 - 0.27 10.9 56.4 0.99 9.0 55.2 2.2 1 1 0 1 1 1 0 Ezrin/radixin/moesin family Uso1_p115_C PF04871.11 MSTRG.15733.1_2 - 0.29 11.4 55.2 2.2 8.5 14.6 3.3 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region TPR_MLP1_2 PF07926.10 MSTRG.15733.1_2 - 0.5 10.3 56.7 9 6.2 23.7 3.9 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein MscS_porin PF12795.5 MSTRG.15733.1_2 - 0.81 9.0 49.4 0.75 9.2 11.5 2.2 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Lectin_N PF03954.12 MSTRG.15733.1_2 - 0.94 9.1 27.7 0.11 12.1 5.9 3.4 2 1 2 4 4 4 0 Hepatic lectin, N-terminal domain EzrA PF06160.10 MSTRG.15733.1_2 - 1.3 7.0 38.0 1.3 7.0 28.8 2.4 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Mga PF05043.11 MSTRG.15733.1_2 - 1.4 9.5 7.1 4.4 7.8 0.3 2.9 3 0 0 3 3 3 0 Mga helix-turn-helix domain BRI3BP PF14965.4 MSTRG.15733.1_2 - 2.6 7.4 4.9 18 4.6 0.3 2.4 2 0 0 2 2 2 0 Negative regulator of p53/TP53 DUF812 PF05667.9 MSTRG.15733.1_2 - 2.6 6.7 49.2 4.3 6.0 26.7 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF812) DUF1664 PF07889.10 MSTRG.15733.1_2 - 2.7 7.9 32.0 2.4 8.0 7.7 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) TBPIP PF07106.11 MSTRG.15733.1_2 - 2.9 7.5 43.6 12 5.5 11.5 3.4 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) BRE1 PF08647.9 MSTRG.15733.1_2 - 5.1 7.1 53.0 0.055 13.4 17.9 3.7 1 1 3 4 4 4 0 BRE1 E3 ubiquitin ligase Lipoprotein_7 PF01540.14 MSTRG.15733.1_2 - 5.4 6.1 22.0 0.15 11.2 9.7 2.7 1 1 1 2 2 2 0 Adhesin lipoprotein Alpha-amylase PF00128.22 MSTRG.15733.1_2 - 6.1 6.2 10.4 1.7 8.0 7.3 1.6 1 1 0 1 1 1 0 Alpha amylase, catalytic domain HMMR_N PF15905.3 MSTRG.15733.1_2 - 6.5 6.0 49.0 13 5.0 13.0 2.6 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Fmp27_SW PF10305.7 MSTRG.15733.1_2 - 6.8 7.4 7.5 21 5.8 1.4 2.6 2 1 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain ATG16 PF08614.9 MSTRG.15733.1_2 - 7.1 6.6 54.1 22 5.0 26.3 2.7 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Leu_zip PF15294.4 MSTRG.15733.1_2 - 7.8 5.8 43.0 49 3.2 12.5 3.0 1 1 1 2 2 2 0 Leucine zipper CENP-F_leu_zip PF10473.7 MSTRG.15733.1_2 - 8.3 6.3 52.6 6.1 6.7 28.2 2.6 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TraF_2 PF13729.4 MSTRG.15733.1_2 - 9.4 5.4 8.2 0.93 8.7 0.5 2.5 1 1 0 2 2 2 0 F plasmid transfer operon, TraF, protein IGF2_C PF08365.9 MSTRG.22121.1_2 - 5.1e-29 99.9 5.2 1e-28 99.0 5.2 1.5 1 0 0 1 1 1 1 Insulin-like growth factor II E-peptide Insulin PF00049.16 MSTRG.22121.1_2 - 2.9e-13 50.5 5.9 6.6e-11 42.9 5.9 2.7 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family zinc_ribbon_9 PF14369.4 MSTRG.22121.1_3 - 0.0067 16.5 2.9 0.022 14.8 2.9 1.9 1 0 0 1 1 1 1 zinc-ribbon ECH_1 PF00378.18 MSTRG.19983.1_1 - 4.9e-16 58.7 0.0 5.5e-16 58.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.3 MSTRG.19983.1_1 - 9.2e-10 38.4 0.0 1e-09 38.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Hema_stalk PF08720.8 MSTRG.19983.1_1 - 0.06 12.9 0.0 0.065 12.8 0.0 1.2 1 0 0 1 1 1 0 Influenza C hemagglutinin stalk Tup_N PF08581.8 MSTRG.5837.1_2 - 0.0048 17.1 9.9 0.012 15.7 9.9 1.7 1 0 0 1 1 1 1 Tup N-terminal FAM76 PF16046.3 MSTRG.5837.1_2 - 0.015 14.5 16.2 0.022 14.0 16.2 1.2 1 0 0 1 1 1 0 FAM76 protein ATG16 PF08614.9 MSTRG.5837.1_2 - 0.018 15.1 16.4 0.058 13.4 16.4 1.8 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) IncA PF04156.12 MSTRG.5837.1_2 - 0.028 14.1 19.1 0.19 11.3 0.3 2.4 1 1 1 2 2 2 0 IncA protein NUDE_C PF04880.11 MSTRG.5837.1_2 - 0.054 13.8 4.1 0.11 12.8 4.1 1.5 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region DUF2089 PF09862.7 MSTRG.5837.1_2 - 0.62 10.0 4.3 0.74 9.7 1.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2089) Fez1 PF06818.13 MSTRG.5837.1_2 - 0.63 10.3 20.3 0.21 11.9 10.8 2.1 1 1 1 2 2 2 0 Fez1 CENP-H PF05837.10 MSTRG.5837.1_2 - 0.92 9.8 20.9 0.18 12.1 4.0 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) TPR_MLP1_2 PF07926.10 MSTRG.5837.1_2 - 1 9.3 19.6 1.7 8.6 10.3 2.6 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein CALCOCO1 PF07888.9 MSTRG.5837.1_2 - 1 7.7 19.1 1.5 7.2 19.1 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spectrin PF00435.19 MSTRG.5837.1_2 - 1.3 9.5 13.6 2.5 8.5 8.4 2.4 2 0 0 2 2 2 0 Spectrin repeat Tropomyosin_1 PF12718.5 MSTRG.5837.1_2 - 1.3 9.0 22.8 0.63 10.0 15.3 2.4 1 1 1 2 2 2 0 Tropomyosin like ADIP PF11559.6 MSTRG.5837.1_2 - 2 8.4 22.6 0.65 9.9 15.3 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding V_ATPase_I PF01496.17 MSTRG.5837.1_2 - 3.5 5.3 6.9 5 4.8 6.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Phage_GP20 PF06810.9 MSTRG.5837.1_2 - 5.7 6.6 17.5 3.7 7.2 1.8 2.3 1 1 1 2 2 2 0 Phage minor structural protein GP20 DUF2681 PF10883.6 MSTRG.5837.1_2 - 6.4 7.1 11.3 55 4.1 0.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2681) DUF3373 PF11853.6 MSTRG.5837.1_2 - 6.8 5.2 6.3 11 4.5 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Spc7 PF08317.9 MSTRG.5837.1_2 - 6.9 5.3 21.2 9.6 4.8 19.6 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein FAM222A PF15258.4 MSTRG.22859.2_1 - 1.2e-217 724.1 36.9 1.7e-217 723.6 36.9 1.2 1 0 0 1 1 1 1 Protein family of FAM222A HEAT PF02985.20 MSTRG.20727.2_2 - 3.9e-08 32.7 1.1 0.011 15.8 0.0 4.3 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.4 MSTRG.20727.2_2 - 4.2e-05 23.7 1.8 0.046 14.0 0.4 4.3 2 1 3 5 5 5 3 HEAT repeats Cnd1 PF12717.5 MSTRG.20727.2_2 - 0.00011 22.1 3.3 0.00075 19.4 1.0 3.2 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 ParcG PF10274.7 MSTRG.20727.2_2 - 0.00016 21.7 0.4 0.025 14.6 0.1 2.7 2 0 0 2 2 2 1 Parkin co-regulated protein Vac14_Fab1_bd PF12755.5 MSTRG.20727.2_2 - 0.00079 19.8 0.9 0.052 14.0 0.1 2.9 3 0 0 3 3 2 1 Vacuolar 14 Fab1-binding region MMS19_C PF12460.6 MSTRG.20727.2_2 - 0.0016 17.5 4.1 0.02 13.9 0.2 2.6 3 0 0 3 3 3 1 RNAPII transcription regulator C-terminal HEAT_EZ PF13513.4 MSTRG.20727.2_2 - 0.003 17.9 0.1 4.3 7.8 0.0 3.0 2 0 0 2 2 2 2 HEAT-like repeat TFCD_C PF12612.6 MSTRG.20727.2_2 - 0.013 15.2 0.4 0.045 13.5 0.2 2.0 2 0 0 2 2 2 0 Tubulin folding cofactor D C terminal MMS19_N PF14500.4 MSTRG.20727.2_2 - 0.013 14.9 1.1 0.097 12.1 0.1 2.3 2 0 0 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II RasGEF_N_2 PF14663.4 MSTRG.20727.2_2 - 0.12 12.6 0.8 0.5 10.6 0.1 2.4 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain RTP1_C1 PF10363.7 MSTRG.20727.2_2 - 0.32 11.0 3.0 1.5 8.9 0.8 3.0 2 1 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Utp13 PF08625.9 MSTRG.20727.2_2 - 0.32 10.7 7.5 1.4 8.7 0.1 3.3 2 1 1 3 3 3 0 Utp13 specific WD40 associated domain Edc3_linker PF16598.3 MSTRG.25108.1_1 - 4.7e-33 113.6 3.5 8.1e-33 112.8 3.5 1.4 1 0 0 1 1 1 1 Linker region of enhancer of mRNA-decapping protein 3 YjeF_N PF03853.13 MSTRG.25108.1_1 - 2.3e-17 63.3 0.0 3.6e-17 62.6 0.0 1.2 1 0 0 1 1 1 1 YjeF-related protein N-terminus LSM14 PF12701.5 MSTRG.25108.1_1 - 5.2e-10 39.1 0.0 9.9e-10 38.2 0.0 1.5 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.8 MSTRG.25108.1_1 - 2.1e-09 38.1 0.0 3.6e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 FDF domain MOZ_SAS PF01853.16 MSTRG.4926.2_1 - 1.2e-80 269.2 0.2 1.9e-80 268.6 0.2 1.3 1 0 0 1 1 1 1 MOZ/SAS family PHD PF00628.27 MSTRG.4926.2_1 - 1e-17 63.6 29.6 8.2e-11 41.5 8.5 3.8 3 1 1 4 4 4 2 PHD-finger Linker_histone PF00538.17 MSTRG.4926.2_1 - 2.7e-07 30.7 0.0 0.00046 20.4 0.0 2.5 2 0 0 2 2 2 2 linker histone H1 and H5 family PHD_2 PF13831.4 MSTRG.4926.2_1 - 0.0054 16.1 2.0 0.0054 16.1 2.0 3.3 3 0 0 3 3 3 2 PHD-finger PHD_4 PF16866.3 MSTRG.4926.2_1 - 0.0057 16.6 6.5 0.0057 16.6 6.5 3.1 1 1 2 3 3 3 1 PHD-finger Acetyltransf_7 PF13508.5 MSTRG.4926.2_1 - 0.01 16.1 0.0 0.027 14.8 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Prok-RING_1 PF14446.4 MSTRG.4926.2_1 - 6.6 6.6 15.0 9.8 6.1 0.5 2.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 NID PF07292.11 MSTRG.10880.2_3 - 2.7e-15 56.7 0.1 1.8e-07 31.6 0.0 3.1 3 0 0 3 3 3 2 Nmi/IFP 35 domain (NID) DUF2457 PF10446.7 MSTRG.10880.2_3 - 0.24 10.4 11.1 0.44 9.5 11.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PHD PF00628.27 MSTRG.10880.2_3 - 1.1 9.1 6.9 2.6 7.9 6.9 1.6 1 0 0 1 1 1 0 PHD-finger VPS9 PF02204.16 MSTRG.14600.1_2 - 3.3e-23 81.7 0.1 6.7e-23 80.7 0.1 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain RA PF00788.21 MSTRG.14600.1_2 - 7.3e-11 42.4 0.0 2.1e-10 40.9 0.0 1.8 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SH2 PF00017.22 MSTRG.14600.1_2 - 0.00013 21.9 0.0 0.00029 20.7 0.0 1.7 1 0 0 1 1 1 1 SH2 domain PI3_PI4_kinase PF00454.25 MSTRG.1853.1_1 - 1.8e-39 135.9 3.2 3.4e-27 95.7 0.4 3.0 2 1 1 3 3 3 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.18 MSTRG.1853.1_1 - 7.7e-35 119.8 0.0 2.3e-34 118.3 0.0 1.8 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Ribosomal_L18_c PF14204.4 MSTRG.1853.1_1 - 0.081 13.7 0.4 0.26 12.0 0.4 1.8 1 0 0 1 1 1 0 Ribosomal L18 C-terminal region YojJ PF10372.7 MSTRG.1853.1_1 - 0.096 12.7 0.2 0.42 10.6 0.2 2.2 1 0 0 1 1 1 0 Bacterial membrane-spanning protein N-terminus CRAL_TRIO PF00650.18 MSTRG.22985.1_3 - 1.4e-32 112.5 0.5 2.8e-32 111.5 0.5 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain Motile_Sperm PF00635.24 MSTRG.22985.1_3 - 2.8e-18 65.6 0.0 5.3e-18 64.7 0.0 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain CRAL_TRIO_2 PF13716.4 MSTRG.22985.1_3 - 5e-06 26.5 0.4 1.2e-05 25.3 0.4 1.6 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain PID PF00640.21 MSTRG.22985.1_3 - 0.029 14.3 0.0 0.072 13.0 0.0 1.6 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) Reeler PF02014.14 MSTRG.22985.1_3 - 0.029 15.0 0.0 0.059 14.0 0.0 1.4 1 0 0 1 1 1 0 Reeler domain PapD-like PF14874.4 MSTRG.22985.1_3 - 0.12 12.5 0.0 0.35 10.9 0.0 1.8 1 0 0 1 1 1 0 Flagellar-associated PapD-like DUF4065 PF13274.4 MSTRG.22985.1_3 - 0.48 11.2 2.8 15 6.4 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF4065) CBFB_NFYA PF02045.13 MSTRG.26737.2_2 - 3e-27 94.9 8.8 4.9e-27 94.3 8.8 1.3 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Peptidase_M60 PF13402.4 MSTRG.21218.2_3 - 1.8e-21 76.5 0.0 3.6e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase M60, enhancin and enhancin-like ATP_Ca_trans_C PF12424.6 MSTRG.21218.2_3 - 0.19 12.1 0.4 0.91 9.9 0.1 2.1 2 0 0 2 2 2 0 Plasma membrane calcium transporter ATPase C terminal Cys_knot PF00007.20 MSTRG.22246.1_2 - 8.6e-14 51.6 11.3 8.6e-14 51.6 11.3 3.9 3 1 1 4 4 4 1 Cystine-knot domain IGFBP PF00219.16 MSTRG.22246.1_2 - 2.5e-10 40.7 22.0 2.5e-10 40.7 22.0 5.6 4 2 1 5 5 5 1 Insulin-like growth factor binding protein VWC PF00093.16 MSTRG.22246.1_2 - 2.3e-09 37.3 13.0 2.3e-09 37.3 13.0 5.1 3 2 1 4 4 4 1 von Willebrand factor type C domain TSP_1 PF00090.17 MSTRG.22246.1_2 - 5.5e-05 23.2 8.3 5.5e-05 23.2 8.3 3.2 3 0 0 3 3 3 1 Thrombospondin type 1 domain SAM_1 PF00536.28 MSTRG.29746.1_3 - 1.5e-14 54.0 0.0 2.2e-14 53.5 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 MSTRG.29746.1_3 - 1.3e-05 25.1 0.0 1.7e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-C3HC4_3 PF13920.4 MSTRG.21946.1_2 - 5.5e-06 26.0 14.6 1.3e-05 24.8 14.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 MSTRG.21946.1_2 - 2.5e-05 23.9 13.9 6.8e-05 22.5 13.9 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) BRE1 PF08647.9 MSTRG.21946.1_2 - 0.0004 20.3 13.5 0.0004 20.3 13.5 8.7 6 2 2 8 8 8 2 BRE1 E3 ubiquitin ligase zf-C3HC4_2 PF13923.4 MSTRG.21946.1_2 - 0.00051 19.7 14.1 0.00051 19.7 14.1 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 MSTRG.21946.1_2 - 0.002 17.9 16.0 0.012 15.5 16.1 2.2 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 MSTRG.21946.1_2 - 0.0068 16.5 12.5 0.0068 16.5 12.5 2.2 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.4 MSTRG.21946.1_2 - 0.013 15.4 10.2 0.035 14.0 10.2 1.8 1 0 0 1 1 1 0 RING-type zinc-finger Prok-RING_4 PF14447.4 MSTRG.21946.1_2 - 0.013 15.2 11.6 0.03 14.0 11.6 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Laminin_II PF06009.10 MSTRG.21946.1_2 - 0.014 15.2 0.9 0.014 15.2 0.9 7.3 4 2 4 9 9 9 0 Laminin Domain II WD40_alt PF14077.4 MSTRG.21946.1_2 - 8.3 6.2 14.7 8.9 6.1 0.6 5.2 4 0 0 4 4 4 0 Alternative WD40 repeat motif Ras PF00071.20 MSTRG.23579.1_1 - 1.3e-65 219.8 0.5 1.7e-65 219.4 0.5 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.23579.1_1 - 4.7e-33 113.8 0.1 7.6e-33 113.2 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.23579.1_1 - 4.8e-16 58.6 0.3 6.9e-16 58.1 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 MSTRG.23579.1_1 - 2.9e-05 23.4 0.2 4.2e-05 22.9 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 MSTRG.23579.1_1 - 0.0011 18.3 0.2 0.0019 17.5 0.2 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.25 MSTRG.23579.1_1 - 0.0037 16.7 0.0 0.0058 16.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 MSTRG.23579.1_1 - 0.023 14.6 0.0 0.038 13.9 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF3963 PF13124.4 MSTRG.23579.1_1 - 0.092 12.6 0.8 0.2 11.5 0.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3963) Sas10_Utp3 PF04000.13 MSTRG.18315.1_1 - 9.3e-17 61.3 0.1 1.3e-16 60.8 0.1 1.2 1 0 0 1 1 1 1 Sas10/Utp3/C1D family DUF932 PF06067.9 MSTRG.18315.1_1 - 0.055 13.1 0.2 0.089 12.4 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF932) fn3 PF00041.19 MSTRG.10137.1_1 - 1.8e-08 34.5 0.0 4.3e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III domain Ank_4 PF13637.4 MSTRG.10137.1_1 - 9.5e-08 32.3 0.0 4.3e-07 30.2 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.5 MSTRG.10137.1_1 - 9e-05 22.9 0.0 0.00031 21.1 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.10137.1_1 - 0.00023 21.3 0.0 0.0013 18.9 0.0 2.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.10137.1_1 - 0.0043 17.3 0.0 1.3 9.7 0.0 3.1 2 0 0 2 2 2 1 Ankyrin repeat zf-RING_7 PF02591.13 MSTRG.1203.2_2 - 0.045 13.8 0.3 0.12 12.4 0.3 1.8 1 0 0 1 1 1 0 C4-type zinc ribbon domain C1q PF00386.19 MSTRG.8129.1_3 - 3.3e-06 27.2 0.1 4.6e-06 26.7 0.1 1.2 1 0 0 1 1 1 1 C1q domain IQ PF00612.25 MSTRG.1034.1_1 - 1.8e-05 24.0 28.9 0.15 11.8 0.6 4.9 5 0 0 5 5 5 4 IQ calmodulin-binding motif P4Ha_N PF08336.9 MSTRG.676.1_1 - 4.7e-29 101.0 0.0 6.5e-29 100.5 0.0 1.2 1 0 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 2OG-FeII_Oxy_3 PF13640.4 MSTRG.676.1_3 - 1.4e-14 54.6 0.1 2.8e-14 53.7 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-A20 PF01754.14 MSTRG.966.2_1 - 2.2e-12 46.5 5.7 3.2e-12 46.0 5.7 1.3 1 0 0 1 1 1 1 A20-like zinc finger NTF2 PF02136.18 MSTRG.19697.1_2 - 2e-26 92.7 0.0 2.8e-26 92.3 0.0 1.2 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain SnoaL_4 PF13577.4 MSTRG.19697.1_2 - 0.0089 16.0 0.0 0.014 15.4 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain p450 PF00067.20 MSTRG.17413.1_3 - 2.3e-81 273.8 0.0 2.6e-81 273.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CDC45 PF02724.12 MSTRG.5016.1_3 - 4.6 5.3 10.3 6.7 4.7 10.3 1.1 1 0 0 1 1 1 0 CDC45-like protein HSP70 PF00012.18 MSTRG.1743.1_2 - 7.3e-260 863.2 5.4 8.5e-260 862.9 5.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 MSTRG.1743.1_2 - 3e-18 65.6 0.3 9.7e-17 60.6 0.0 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.4 MSTRG.1743.1_2 - 0.0038 17.5 0.7 8 6.8 0.0 3.3 3 1 0 3 3 3 2 Cell division protein FtsA RE_AlwI PF09491.8 MSTRG.1743.1_2 - 0.01 14.5 1.3 0.019 13.6 1.3 1.3 1 0 0 1 1 1 0 AlwI restriction endonuclease FGGY_C PF02782.14 MSTRG.1743.1_2 - 0.058 13.0 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.16 MSTRG.1743.1_2 - 0.072 12.2 0.8 0.26 10.4 0.1 2.2 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase EGF_2 PF07974.11 MSTRG.25123.1_3 - 0.00031 20.9 14.6 0.00068 19.8 14.6 1.6 1 0 0 1 1 1 1 EGF-like domain BNR PF02012.18 MSTRG.25123.1_3 - 0.065 13.1 2.2 0.13 12.2 0.1 2.5 2 0 0 2 2 2 0 BNR/Asp-box repeat Ribosomal_L14 PF00238.17 MSTRG.24154.1_1 - 4.7e-34 116.9 0.2 6.1e-34 116.6 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e R3H PF01424.20 MSTRG.26988.5_2 - 3.7e-11 42.7 0.0 7.1e-11 41.8 0.0 1.5 1 0 0 1 1 1 1 R3H domain SUZ PF12752.5 MSTRG.26988.5_2 - 9.3e-11 42.2 1.7 9.3e-11 42.2 1.7 4.5 3 0 0 3 3 3 1 SUZ domain RRM_1 PF00076.20 MSTRG.11413.1_1 - 8.5e-39 131.1 0.3 9.5e-15 54.1 0.0 4.2 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.11413.1_1 - 9.7e-05 22.3 0.1 0.14 12.1 0.0 3.0 3 0 0 3 3 3 2 RNA recognition motif RRM_5 PF13893.4 MSTRG.11413.1_1 - 0.00011 21.6 0.0 0.014 14.9 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.6 MSTRG.11413.1_1 - 0.0013 18.6 0.0 0.021 14.8 0.0 2.6 3 0 0 3 3 3 1 Limkain b1 ERp29 PF07749.10 MSTRG.11413.1_1 - 0.12 13.1 0.0 0.25 12.1 0.0 1.4 1 0 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain Nup35_RRM_2 PF14605.4 MSTRG.11413.1_1 - 0.56 10.1 1.9 7.4 6.5 0.0 2.7 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Clathrin PF00637.18 MSTRG.13320.4_1 - 6.2e-27 94.1 0.3 6.2e-27 94.1 0.3 2.8 3 0 0 3 3 3 1 Region in Clathrin and VPS Vps39_2 PF10367.7 MSTRG.13320.4_1 - 4.5e-05 23.7 0.5 0.00014 22.1 0.5 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.7 MSTRG.13320.4_1 - 0.00073 19.7 2.9 0.04 14.1 0.0 3.3 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 TPR_7 PF13176.4 MSTRG.13320.4_1 - 0.0078 16.0 2.4 0.35 10.9 1.1 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.13320.4_1 - 0.07 13.3 3.4 0.21 11.8 0.2 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.13320.4_1 - 0.073 13.1 3.4 5.7 7.2 0.3 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat zf-rbx1 PF12678.5 MSTRG.13320.4_1 - 0.33 11.1 3.0 1.3 9.3 3.0 2.1 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3H2C3 PF17122.3 MSTRG.13320.4_1 - 2.2 8.2 5.5 0.24 11.3 0.5 2.0 2 0 0 2 2 2 0 Zinc-finger zf-RING_2 PF13639.4 MSTRG.13320.4_1 - 2.3 8.4 9.9 0.37 11.0 5.1 2.3 2 0 0 2 2 2 0 Ring finger domain zf-RING_5 PF14634.4 MSTRG.13320.4_1 - 4.6 7.1 6.8 5.5 6.9 4.8 2.3 2 1 0 2 2 2 0 zinc-RING finger domain zf-RING_11 PF17123.3 MSTRG.13320.4_1 - 9.9 5.9 9.2 0.28 10.8 2.5 2.0 2 0 0 2 2 2 0 RING-like zinc finger Sortilin-Vps10 PF15902.3 MSTRG.25986.2_2 - 3.8e-107 358.7 1.5 6.3e-107 358.0 1.5 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.3 MSTRG.25986.2_2 - 2.3e-38 132.1 8.2 2.3e-38 132.1 8.2 1.5 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal PKD PF00801.18 MSTRG.25986.2_2 - 1.2e-10 40.9 0.8 4.6e-06 26.2 0.0 2.6 2 0 0 2 2 2 2 PKD domain BNR_6 PF15899.3 MSTRG.25986.2_2 - 0.00078 19.2 0.4 1.8 8.8 0.0 4.0 4 0 0 4 4 4 2 BNR-Asp box repeat BNR PF02012.18 MSTRG.25986.2_2 - 0.018 14.8 16.1 19 5.7 0.1 6.6 6 0 0 6 6 6 0 BNR/Asp-box repeat Tubulin PF00091.23 MSTRG.23297.1_2 - 1.9e-68 230.4 0.0 2.8e-68 229.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 MSTRG.23297.1_2 - 6.4e-42 142.6 0.1 9.8e-42 142.0 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.7 MSTRG.23297.1_2 - 1.4e-05 25.3 0.0 3.2e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.4 MSTRG.23297.1_2 - 0.022 13.8 0.0 0.04 13.0 0.0 1.4 1 0 0 1 1 1 0 Tubulin like Tubulin_3 PF14881.4 MSTRG.23297.1_2 - 0.026 14.1 0.0 0.049 13.2 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain LIM PF00412.20 MSTRG.9124.1_2 - 4.7e-32 109.9 33.3 2.3e-11 43.6 1.6 3.8 3 0 0 3 3 3 3 LIM domain SNF PF00209.16 MSTRG.26758.3_3 - 7e-211 701.3 34.2 9.2e-211 700.9 34.2 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family PsaX PF08078.10 MSTRG.14794.1_2 - 0.07 13.0 1.0 0.16 11.9 1.0 1.6 1 0 0 1 1 1 0 PsaX family zf-H2C2_2 PF13465.4 MSTRG.14794.1_3 - 1.4e-09 37.8 21.6 9e-07 28.9 1.5 4.8 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.14794.1_3 - 9.7e-08 31.9 23.3 2.7e-05 24.2 2.9 5.1 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.14794.1_3 - 0.38 11.6 32.5 0.27 12.0 1.9 5.0 4 0 0 4 4 4 0 C2H2-type zinc finger La PF05383.15 MSTRG.10462.1_1 - 1.4e-13 50.5 0.1 2.4e-13 49.8 0.1 1.4 1 0 0 1 1 1 1 La domain G-alpha PF00503.18 MSTRG.14018.1_2 - 3.2e-125 417.8 3.0 4.1e-125 417.5 3.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 MSTRG.14018.1_2 - 2e-16 59.8 1.2 2.8e-12 46.3 0.1 2.5 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 MSTRG.14018.1_2 - 6.5e-05 22.3 0.3 0.041 13.1 0.1 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.11 MSTRG.14018.1_2 - 0.00087 19.4 0.3 1.9 8.6 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 MSTRG.14018.1_2 - 0.02 15.1 0.0 0.037 14.3 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Amino_oxidase PF01593.22 MSTRG.7635.1_1 - 7.8e-72 242.8 0.0 7e-71 239.7 0.0 1.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.4 MSTRG.7635.1_1 - 1.1e-13 51.0 0.2 2.3e-13 50.0 0.2 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 MSTRG.7635.1_1 - 0.00043 19.9 0.0 0.00065 19.3 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.10 MSTRG.7635.1_1 - 0.0019 17.2 0.3 1.1 8.1 0.4 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein FAD_binding_2 PF00890.22 MSTRG.7635.1_1 - 0.022 13.7 1.3 0.033 13.2 1.3 1.2 1 0 0 1 1 1 0 FAD binding domain ThiF PF00899.19 MSTRG.7635.1_1 - 0.084 12.1 0.6 0.14 11.4 0.6 1.2 1 0 0 1 1 1 0 ThiF family Thi4 PF01946.15 MSTRG.7635.1_1 - 0.12 11.4 0.9 0.19 10.8 0.9 1.2 1 0 0 1 1 1 0 Thi4 family F420_oxidored PF03807.15 MSTRG.7635.1_1 - 0.14 12.6 1.3 1 9.9 1.3 2.1 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_9 PF13454.4 MSTRG.7635.1_1 - 0.14 12.0 1.5 0.74 9.7 0.6 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox_2 PF07992.12 MSTRG.7635.1_1 - 0.18 10.9 0.8 0.37 9.9 0.8 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.5 MSTRG.7635.1_1 - 0.2 10.8 0.3 0.48 9.6 0.4 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.4 MSTRG.7635.1_1 - 0.21 10.7 2.2 0.28 10.2 1.4 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.12 MSTRG.7635.1_1 - 0.69 8.4 1.7 2.5 6.6 1.7 1.7 2 0 0 2 2 2 0 HI0933-like protein GATA PF00320.25 MSTRG.27886.1_3 - 1.9e-13 49.7 5.8 1.9e-13 49.7 5.8 2.7 2 0 0 2 2 2 1 GATA zinc finger Crystall PF00030.17 MSTRG.11600.1_1 - 2.5e-49 165.3 0.2 1.8e-23 82.4 0.0 2.0 2 0 0 2 2 2 2 Beta/Gamma crystallin WSD PF15613.4 MSTRG.17092.1_1 - 2.8e-09 37.2 0.0 3.9e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif I-set PF07679.14 MSTRG.1083.1_3 - 1.2e-11 44.3 0.0 1.2e-07 31.6 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.1083.1_3 - 4.8e-08 33.4 0.8 1.2e-05 25.7 0.0 2.9 3 1 0 3 3 3 1 Immunoglobulin domain V-set PF07686.15 MSTRG.1083.1_3 - 7.5e-07 29.1 0.0 2.3e-06 27.6 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.4 MSTRG.1083.1_3 - 0.00045 20.4 0.2 0.11 12.7 0.0 3.6 4 2 0 4 4 4 1 Immunoglobulin domain Izumo-Ig PF16706.3 MSTRG.1083.1_3 - 0.00057 19.8 0.0 0.0011 18.8 0.0 1.4 1 0 0 1 1 1 1 Izumo-like Immunoglobulin domain ig PF00047.23 MSTRG.1083.1_3 - 0.0032 17.5 6.4 0.04 13.9 0.0 3.8 3 2 0 3 3 3 1 Immunoglobulin domain C2-set_2 PF08205.10 MSTRG.1083.1_3 - 0.074 13.0 0.0 0.074 13.0 0.0 3.4 3 1 1 4 4 4 0 CD80-like C2-set immunoglobulin domain WT1 PF02165.13 MSTRG.1083.1_3 - 0.39 9.8 8.2 0.69 9.0 8.2 1.3 1 0 0 1 1 1 0 Wilm's tumour protein WD40 PF00400.30 MSTRG.9699.1_3 - 0.023 15.4 0.0 0.054 14.2 0.0 1.6 1 0 0 1 1 1 0 WD domain, G-beta repeat T2SS-T3SS_pil_N PF13629.4 MSTRG.9699.1_3 - 0.18 11.4 0.0 0.21 11.3 0.0 1.1 1 0 0 1 1 1 0 Pilus formation protein N terminal region CD36 PF01130.19 MSTRG.19646.7_3 - 1e-133 446.2 0.1 1.2e-133 446.0 0.1 1.0 1 0 0 1 1 1 1 CD36 family Ribosomal_S17_N PF16205.3 MSTRG.24666.1_3 - 3.8e-33 113.5 0.5 4.8e-33 113.2 0.5 1.1 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Histone_H2A_C PF16211.3 MSTRG.17993.1_2 - 2e-15 56.1 0.0 3.6e-15 55.3 0.0 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.22 MSTRG.17993.1_2 - 1.1e-13 51.5 0.0 1.8e-13 50.9 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 MSTRG.17993.1_2 - 5.4e-08 32.9 0.0 7.7e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF410 PF04190.11 MSTRG.459.1_1 - 5.8e-76 255.5 0.1 7.5e-76 255.1 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) Lig_chan-Glu_bd PF10613.7 MSTRG.6897.1_1 - 1.3e-31 109.0 0.0 1.2e-30 105.9 0.0 2.1 1 1 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 MSTRG.6897.1_1 - 4.3e-11 42.5 0.0 6.4e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 ANF_receptor PF01094.26 MSTRG.6897.1_1 - 5.8e-10 38.7 0.0 1.4e-06 27.6 0.0 2.1 1 1 0 2 2 2 2 Receptor family ligand binding region Lig_chan PF00060.24 MSTRG.6897.1_1 - 0.0089 15.7 0.1 0.016 14.9 0.1 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel Paf67 PF10255.7 MSTRG.14760.1_2 - 1.6e-178 593.7 11.4 1.6e-178 593.7 11.4 1.4 2 0 0 2 2 2 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.15 MSTRG.14760.1_2 - 0.0072 16.2 0.5 0.09 12.8 0.2 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.14760.1_2 - 0.036 13.8 0.3 0.83 9.5 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.14760.1_2 - 0.064 13.3 0.1 0.15 12.2 0.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 Inhibitor_I53 PF11714.6 MSTRG.14760.1_2 - 0.082 13.0 0.2 0.15 12.1 0.2 1.4 1 0 0 1 1 1 0 Thrombin inhibitor Madanin La PF05383.15 MSTRG.14259.1_1 - 3.6e-17 62.0 0.2 6e-17 61.3 0.2 1.4 1 0 0 1 1 1 1 La domain ATP_sub_h PF10775.7 MSTRG.14259.1_1 - 7.3 6.5 7.9 11 5.9 1.9 3.1 3 0 0 3 3 3 0 ATP synthase complex subunit h Trypsin PF00089.24 MSTRG.14769.2_3 - 2.6e-66 223.5 0.7 3.3e-66 223.1 0.7 1.1 1 0 0 1 1 1 1 Trypsin Kringle PF00051.16 MSTRG.14769.2_3 - 3.7e-21 75.1 2.4 8.7e-21 73.9 2.4 1.7 1 0 0 1 1 1 1 Kringle domain EGF PF00008.25 MSTRG.14769.2_3 - 1e-12 47.9 52.5 1.7e-07 31.3 9.0 4.8 4 0 0 4 4 4 3 EGF-like domain EGF_2 PF07974.11 MSTRG.14769.2_3 - 0.0011 19.2 44.9 0.087 13.1 11.2 4.4 3 0 0 3 3 3 2 EGF-like domain hEGF PF12661.5 MSTRG.14769.2_3 - 0.0011 19.4 5.4 0.0011 19.4 5.4 5.5 6 0 0 6 6 6 2 Human growth factor-like EGF FAP PF07174.9 MSTRG.14769.2_3 - 0.45 9.8 16.7 0.89 8.8 16.7 1.4 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) RunxI PF08504.9 MSTRG.20216.2_1 - 1.1e-33 115.7 5.3 2.1e-33 114.8 5.3 1.4 1 0 0 1 1 1 1 Runx inhibition domain DUF4719 PF15843.3 MSTRG.20216.2_1 - 0.037 14.0 0.5 0.055 13.5 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4719) Fumble PF03630.12 MSTRG.18331.2_1 - 2.4e-120 401.6 0.0 3e-120 401.2 0.0 1.1 1 0 0 1 1 1 1 Fumble ATP_Ca_trans_C PF12424.6 MSTRG.20462.1_1 - 2.9e-10 40.3 0.1 8e-10 38.9 0.1 1.8 1 0 0 1 1 1 1 Plasma membrane calcium transporter ATPase C terminal ATP_Ca_trans_C PF12424.6 MSTRG.20462.1_3 - 2.1e-13 50.4 1.6 5.8e-13 49.0 1.6 1.7 1 0 0 1 1 1 1 Plasma membrane calcium transporter ATPase C terminal Ion_trans PF00520.29 MSTRG.14098.1_3 - 2.5e-18 66.1 15.2 5.9e-18 64.9 15.2 1.7 1 0 0 1 1 1 1 Ion transport protein DUF1830 PF08865.9 MSTRG.14098.1_3 - 0.091 12.6 0.1 0.2 11.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1830) Sec2p PF06428.9 MSTRG.14098.1_3 - 0.096 12.5 4.2 0.22 11.3 4.2 1.5 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p IncA PF04156.12 MSTRG.14098.1_3 - 0.12 12.0 0.1 0.12 12.0 0.1 2.1 3 0 0 3 3 3 0 IncA protein Glyco_hydro_47 PF01532.18 MSTRG.19634.1_1 - 6.2e-115 384.6 0.0 1.1e-114 383.8 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 PA PF02225.20 MSTRG.19634.1_1 - 4.4e-08 33.0 0.0 7.9e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 PA domain Glyco_hydro_127 PF07944.10 MSTRG.19634.1_1 - 0.2 10.0 0.1 0.32 9.3 0.1 1.2 1 0 0 1 1 1 0 Beta-L-arabinofuranosidase, GH127 TFIIE-A_C PF11521.6 MSTRG.19634.1_1 - 1.9 8.8 6.7 1.6 9.0 2.6 2.3 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha Sec23_trunk PF04811.13 MSTRG.20880.3_2 - 5e-82 275.0 0.0 9.2e-82 274.1 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.13 MSTRG.20880.3_2 - 4.5e-29 100.2 1.4 1.1e-28 99.0 1.4 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.10 MSTRG.20880.3_2 - 2.4e-21 76.1 0.0 5.1e-21 75.1 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.13 MSTRG.20880.3_2 - 2.5e-14 52.9 5.4 5.6e-14 51.8 5.4 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.20 MSTRG.20880.3_2 - 8.2e-06 25.5 0.0 2.3e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 Gelsolin repeat HpaB PF03241.11 MSTRG.20880.3_2 - 0.0021 17.1 0.0 0.11 11.5 0.0 2.2 2 0 0 2 2 2 1 4-hydroxyphenylacetate 3-hydroxylase C terminal Cwf_Cwc_15 PF04889.10 MSTRG.20880.3_2 - 0.39 10.3 2.5 0.6 9.7 2.5 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein FAM176 PF14851.4 MSTRG.20880.3_2 - 1.4 8.5 3.1 2.4 7.7 3.1 1.3 1 0 0 1 1 1 0 FAM176 family Ribosomal_60s PF00428.17 MSTRG.20880.3_2 - 1.4 9.3 6.4 3.6 8.1 6.4 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein NOA36 PF06524.10 MSTRG.20880.3_2 - 1.8 7.8 5.2 3.1 7.0 5.2 1.3 1 0 0 1 1 1 0 NOA36 protein TFIIA PF03153.11 MSTRG.20880.3_2 - 3.5 7.4 12.0 6.3 6.5 12.0 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CENP-B_dimeris PF09026.8 MSTRG.20880.3_2 - 6.5 7.1 9.3 22 5.4 9.3 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Ig_3 PF13927.4 MSTRG.22619.1_1 - 1.1e-11 45.1 0.0 1.3e-11 44.8 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 MSTRG.22619.1_1 - 2.5e-09 37.0 0.0 3.2e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 MSTRG.22619.1_1 - 1.7e-08 34.3 0.0 2.1e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.22619.1_1 - 2.6e-06 27.5 0.1 3.1e-06 27.3 0.1 1.1 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 MSTRG.22619.1_1 - 8.4e-06 25.8 0.1 0.00053 20.0 0.1 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain C1-set PF07654.13 MSTRG.22619.1_1 - 4.4e-05 23.7 0.0 5e-05 23.6 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin C1-set domain DUF2650 PF10853.6 MSTRG.7232.1_2 - 0.98 9.1 7.5 2.8 7.6 1.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2650) IMD PF08397.9 MSTRG.24150.1_3 - 1.1e-85 286.4 3.7 1.4e-85 286.1 3.7 1.1 1 0 0 1 1 1 1 IRSp53/MIM homology domain SH3_9 PF14604.4 MSTRG.24150.1_3 - 6.7e-11 41.7 0.0 1.3e-10 40.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.24150.1_3 - 1.8e-07 30.6 0.0 3.2e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.24150.1_3 - 3.6e-05 23.1 0.0 6.6e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain Peptidase_Mx1 PF15890.3 MSTRG.24150.1_3 - 0.13 11.6 2.8 0.24 10.7 2.8 1.4 1 1 0 1 1 1 0 Putative zinc-binding metallo-peptidase DUF3510 PF12022.6 MSTRG.24150.1_3 - 0.16 12.3 3.0 2 8.7 2.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3510) Hemopexin PF00045.17 MSTRG.758.2_1 - 1.3e-12 47.3 4.7 3.3e-06 26.8 0.2 3.5 3 0 0 3 3 3 3 Hemopexin Peptidase_M10 PF00413.22 MSTRG.758.2_2 - 6.8e-53 178.6 0.0 9.8e-53 178.1 0.0 1.2 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 MSTRG.758.2_2 - 7.3e-15 54.5 4.9 3.5e-11 42.7 0.1 2.6 2 0 0 2 2 2 2 Hemopexin Reprolysin_4 PF13583.4 MSTRG.758.2_2 - 0.05 13.1 0.0 0.082 12.4 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.3 MSTRG.758.2_2 - 0.12 11.4 0.3 0.19 10.8 0.3 1.2 1 0 0 1 1 1 0 Met-zincin RabGAP-TBC PF00566.16 MSTRG.11386.2_3 - 1.8e-51 174.7 0.1 3.8e-51 173.7 0.1 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF3350 PF11830.6 MSTRG.11386.2_3 - 1.3e-16 60.5 6.9 1.3e-16 60.5 6.9 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3350) PID PF00640.21 MSTRG.11386.2_3 - 1.1e-09 38.4 0.7 4.3e-09 36.4 0.7 2.1 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Snapin_Pallidin PF14712.4 MSTRG.11386.2_3 - 0.81 10.0 13.2 0.72 10.2 1.2 3.2 2 1 1 3 3 3 0 Snapin/Pallidin EZH2_WD-Binding PF11616.6 MSTRG.17986.2_1 - 0.34 10.9 0.9 0.6 10.1 0.2 1.8 2 0 0 2 2 2 0 WD repeat binding protein EZH2 RHD_DNA_bind PF00554.20 MSTRG.17986.2_2 - 1.9e-56 190.5 0.0 2.7e-56 190.0 0.0 1.3 1 0 0 1 1 1 1 Rel homology DNA-binding domain RHD_dimer PF16179.3 MSTRG.17986.2_2 - 4.2e-35 119.8 0.1 8.3e-35 118.8 0.1 1.5 1 0 0 1 1 1 1 Rel homology dimerisation domain Calpain_III PF01067.20 MSTRG.4082.3_1 - 4.8e-37 127.3 0.0 7.7e-37 126.6 0.0 1.3 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_8 PF13833.4 MSTRG.4082.3_1 - 1.2e-05 24.9 0.1 2.2e-05 24.0 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 MSTRG.4082.3_1 - 2e-05 23.7 0.2 7.8e-05 21.8 0.2 2.0 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 MSTRG.4082.3_1 - 0.044 13.6 0.1 2.3 8.2 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain Peptidase_C2 PF00648.19 MSTRG.4082.3_3 - 1.4e-89 299.9 0.0 1.9e-89 299.5 0.0 1.1 1 0 0 1 1 1 1 Calpain family cysteine protease EF-hand_6 PF13405.4 MSTRG.4082.3_3 - 2.1e-06 27.1 0.1 0.00045 19.8 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.30 MSTRG.4082.3_3 - 0.00033 19.8 0.1 0.0026 17.0 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.4 MSTRG.4082.3_3 - 0.0013 19.1 1.7 0.0018 18.5 0.2 2.0 2 1 0 2 2 2 1 EF-hand domain pair EGF PF00008.25 MSTRG.16840.1_1 - 4.2e-204 659.8 593.0 6.5e-09 35.8 7.7 38.3 39 0 0 39 39 36 36 EGF-like domain hEGF PF12661.5 MSTRG.16840.1_1 - 3.8e-117 379.3 500.5 3.5e-06 27.3 7.8 39.1 38 0 0 38 38 36 34 Human growth factor-like EGF EGF_CA PF07645.13 MSTRG.16840.1_1 - 1.9e-50 168.6 587.0 4.4e-11 42.7 6.5 38.3 22 9 16 38 38 34 23 Calcium-binding EGF domain EGF_2 PF07974.11 MSTRG.16840.1_1 - 7.7e-36 122.0 643.3 0.0022 18.2 9.9 39.2 37 1 1 38 38 37 26 EGF-like domain Ank_2 PF12796.5 MSTRG.16840.1_1 - 8.6e-27 93.4 6.0 8.3e-13 48.6 1.5 4.2 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.28 MSTRG.16840.1_1 - 9e-25 85.9 7.0 0.00018 21.7 0.0 7.2 6 0 0 6 6 6 6 Ankyrin repeat Notch PF00066.15 MSTRG.16840.1_1 - 1.3e-24 86.2 59.9 1.4e-11 44.5 15.4 15.5 16 3 2 18 18 4 3 LNR domain NOD PF06816.11 MSTRG.16840.1_1 - 7.2e-24 83.0 0.1 1.2e-23 82.3 0.1 1.4 1 0 0 1 1 1 1 NOTCH protein DUF3454 PF11936.6 MSTRG.16840.1_1 - 1.7e-23 82.7 19.5 1.7e-23 82.7 19.5 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3454) NODP PF07684.10 MSTRG.16840.1_1 - 2.4e-22 78.7 0.1 2.4e-22 78.7 0.1 3.8 4 0 0 4 4 1 1 NOTCH protein Ank_5 PF13857.4 MSTRG.16840.1_1 - 8.9e-19 67.2 14.6 3.5e-08 33.5 0.2 5.8 4 2 2 6 6 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.16840.1_1 - 1.6e-18 64.7 3.6 0.0015 18.7 0.0 7.5 7 0 0 7 7 7 4 Ankyrin repeat Ank_4 PF13637.4 MSTRG.16840.1_1 - 8.8e-16 57.9 5.1 2.5e-05 24.6 0.2 5.6 4 2 2 6 6 6 4 Ankyrin repeats (many copies) EGF_3 PF12947.5 MSTRG.16840.1_1 - 3e-05 24.0 27.9 0.00021 21.3 4.8 38.6 30 8 8 38 38 36 15 EGF domain cEGF PF12662.5 MSTRG.16840.1_1 - 0.0036 17.1 0.7 0.0036 17.1 0.7 35.1 35 0 0 35 35 32 11 Complement Clr-like EGF-like RUN PF02759.17 MSTRG.19464.1_1 - 4e-30 104.4 0.0 7e-30 103.6 0.0 1.4 1 0 0 1 1 1 1 RUN domain DUF3338 PF11819.6 MSTRG.19464.1_1 - 0.3 11.0 3.3 0.22 11.4 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3338) 2-Hacid_dh_C PF02826.17 MSTRG.4886.2_1 - 2.5e-54 183.2 0.0 3.6e-54 182.7 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.28 MSTRG.4886.2_1 - 3.4e-28 97.8 0.0 4.8e-28 97.3 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.13 MSTRG.4886.2_1 - 0.0066 16.5 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase fn3 PF00041.19 MSTRG.26096.1_3 - 5.6e-06 26.5 0.7 0.0028 17.8 1.0 2.1 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 MSTRG.26096.1_3 - 0.054 13.9 0.4 0.27 11.7 0.3 1.9 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain Big_4 PF07532.9 MSTRG.26096.1_3 - 0.059 12.9 0.3 0.084 12.4 0.3 1.3 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 4) TGF_beta PF00019.18 MSTRG.8778.1_1 - 5.3e-36 123.6 0.8 6.3e-36 123.3 0.8 1.1 1 0 0 1 1 1 1 Transforming growth factor beta like domain WD40 PF00400.30 MSTRG.14180.1_2 - 7.2e-62 203.7 21.0 3.5e-09 37.0 0.1 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.14180.1_2 - 7.6e-22 77.3 0.3 7.2e-05 22.9 0.0 5.8 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 MSTRG.14180.1_2 - 9.7e-09 34.5 6.1 0.11 11.4 0.1 4.8 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.9 MSTRG.14180.1_2 - 2e-07 30.9 0.6 0.0044 16.8 0.0 3.2 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.14 MSTRG.14180.1_2 - 0.00066 18.2 0.0 0.48 8.8 0.0 3.0 1 1 2 3 3 3 3 Cytochrome D1 heme domain DEAD PF00270.27 MSTRG.20349.1_1 - 4.5e-53 179.5 0.0 2.8e-52 176.9 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.20349.1_1 - 6.7e-31 106.8 0.0 2.2e-30 105.2 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.20349.1_1 - 0.0018 18.2 0.0 0.0085 16.0 0.0 2.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF3698 PF12479.6 MSTRG.20349.1_1 - 0.26 11.7 1.6 1.2 9.6 1.6 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3698) 4_1_CTD PF05902.11 MSTRG.18852.1_3 - 2.3e-48 162.7 11.9 6.3e-48 161.3 11.9 1.8 1 0 0 1 1 1 1 4.1 protein C-terminal domain (CTD) SAB PF04382.11 MSTRG.18852.1_3 - 4.4e-24 84.2 3.4 4.4e-24 84.2 3.4 2.1 2 0 0 2 2 2 1 SAB domain FERM_C PF09380.8 MSTRG.18852.1_3 - 5.1e-23 81.1 0.0 1.2e-22 80.0 0.0 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.16 MSTRG.18852.1_3 - 6.8e-18 65.0 1.5 8.3e-18 64.8 0.2 1.9 2 0 0 2 2 2 1 FERM central domain FA PF08736.9 MSTRG.18852.1_3 - 3.8e-17 62.0 3.9 3.8e-17 62.0 3.9 2.6 2 0 0 2 2 2 1 FERM adjacent (FA) FERM_N PF09379.8 MSTRG.18852.1_3 - 4.4e-15 55.2 0.2 1.5e-14 53.6 0.5 1.8 2 0 0 2 2 2 1 FERM N-terminal domain Vps36-NZF-N PF16988.3 MSTRG.17766.1_3 - 0.044 13.0 0.2 0.059 12.6 0.2 1.2 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain EP400_N PF15790.3 MSTRG.655.3_1 - 0.081 11.6 0.0 0.14 10.8 0.0 1.4 1 0 0 1 1 1 0 E1A-binding protein p400, N-terminal Pro_isomerase PF00160.19 MSTRG.5032.1_2 - 9.4e-45 152.6 0.2 1.3e-44 152.1 0.2 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Pkinase PF00069.23 MSTRG.6181.3_1 - 1.6e-71 240.7 0.0 2.4e-71 240.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.6181.3_1 - 5.1e-52 176.6 0.0 7.8e-52 176.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Mst1_SARAH PF11629.6 MSTRG.6181.3_1 - 6.5e-25 86.8 4.0 1.8e-24 85.4 4.0 1.8 1 0 0 1 1 1 1 C terminal SARAH domain of Mst1 CKAP2_C PF15297.4 MSTRG.6181.3_1 - 1.2 8.1 9.0 0.43 9.5 6.4 1.5 1 1 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus DUF2870 PF11069.6 MSTRG.6181.3_1 - 3.5 7.9 7.2 0.13 12.5 0.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2870) RhoGAP PF00620.25 MSTRG.18121.1_1 - 7.5e-38 129.6 0.0 1.2e-37 128.9 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain PYC_OADA PF02436.16 MSTRG.6660.1_2 - 5.2e-70 235.1 0.0 9.6e-70 234.2 0.0 1.4 2 0 0 2 2 2 1 Conserved carboxylase domain Biotin_lipoyl PF00364.20 MSTRG.6660.1_2 - 6.7e-19 67.4 2.2 1.5e-18 66.2 2.2 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.4 MSTRG.6660.1_2 - 8.5e-07 28.6 0.2 0.00013 21.6 0.0 2.8 2 1 1 3 3 3 1 Biotin-lipoyl like RnfC_N PF13375.4 MSTRG.6660.1_2 - 1.1e-05 25.2 0.2 2.2e-05 24.2 0.2 1.5 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain NQRA PF05896.9 MSTRG.6660.1_2 - 0.0024 17.2 0.5 0.0039 16.5 0.5 1.2 1 0 0 1 1 1 1 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) GCV_H PF01597.17 MSTRG.6660.1_2 - 0.0061 16.3 0.2 0.012 15.3 0.2 1.4 1 0 0 1 1 1 1 Glycine cleavage H-protein PTS_EIIA_1 PF00358.18 MSTRG.6660.1_2 - 0.016 14.8 0.8 0.64 9.7 0.1 3.1 2 1 1 3 3 3 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 HlyD_3 PF13437.4 MSTRG.6660.1_2 - 0.023 15.3 0.1 0.45 11.1 0.1 2.4 1 1 1 2 2 2 0 HlyD family secretion protein HlyD_D23 PF16576.3 MSTRG.6660.1_2 - 0.036 13.2 0.0 0.18 10.9 0.0 1.8 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion EB1 PF03271.15 MSTRG.19894.2_3 - 3.3e-17 62.3 0.7 3.3e-17 62.3 0.7 2.4 2 0 0 2 2 2 1 EB1-like C-terminal motif CH PF00307.29 MSTRG.19894.2_3 - 2.1e-11 43.9 1.3 3.5e-11 43.1 0.4 1.8 2 0 0 2 2 2 1 Calponin homology (CH) domain Herpes_gI PF01688.15 MSTRG.19894.2_3 - 0.054 13.3 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein I CAMSAP_CH PF11971.6 MSTRG.19894.2_3 - 0.092 12.5 0.1 0.2 11.4 0.1 1.5 1 0 0 1 1 1 0 CAMSAP CH domain Rep_fac-A_C PF08646.8 MSTRG.10096.2_3 - 8.2e-59 197.4 10.6 2.3e-54 183.0 6.7 3.3 3 0 0 3 3 3 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.3 MSTRG.10096.2_3 - 1.3e-32 111.5 1.2 8e-32 108.9 0.4 2.2 2 0 0 2 2 2 1 Replication protein A OB domain Rep-A_N PF04057.10 MSTRG.10096.2_3 - 1.1e-23 83.0 0.0 2.3e-23 82.0 0.0 1.6 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.23 MSTRG.10096.2_3 - 2.9e-13 49.5 2.0 7.4e-11 41.8 0.6 3.6 4 0 0 4 4 4 1 OB-fold nucleic acid binding domain HHH_5 PF14520.4 MSTRG.14926.1_1 - 1e-07 32.3 0.0 2.2e-07 31.3 0.0 1.5 1 1 0 1 1 1 1 Helix-hairpin-helix domain HHH PF00633.21 MSTRG.14926.1_1 - 0.00044 19.8 0.0 0.00072 19.2 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_2 PF12826.5 MSTRG.14926.1_1 - 0.00058 19.8 0.0 0.00096 19.1 0.0 1.3 1 0 0 1 1 1 1 Helix-hairpin-helix motif Antifungal_prot PF11402.6 MSTRG.14926.1_1 - 0.67 10.1 4.6 1.6 8.9 0.8 2.8 2 0 0 2 2 2 0 Antifungal protein Rad10 PF03834.12 MSTRG.14926.1_2 - 4.8e-43 145.7 0.0 7.7e-43 145.0 0.0 1.3 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) RR_TM4-6 PF06459.10 MSTRG.21553.1_1 - 0.95 9.1 7.0 1.5 8.4 7.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1510 PF07423.9 MSTRG.21553.1_1 - 1.8 7.8 7.4 3.2 7.0 7.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) NPR3 PF03666.11 MSTRG.21553.1_1 - 2.1 6.9 5.6 3.6 6.1 5.6 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CDC45 PF02724.12 MSTRG.21553.1_1 - 2.2 6.4 11.9 3.7 5.6 11.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Asp-B-Hydro_N PF05279.9 MSTRG.21553.1_1 - 4.5 7.1 9.3 6.6 6.6 9.3 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Presenilin PF01080.15 MSTRG.21553.1_1 - 8.1 4.9 7.5 15 4.0 7.5 1.3 1 0 0 1 1 1 0 Presenilin DUF1604 PF07713.11 MSTRG.21553.1_3 - 3.2e-36 122.9 0.3 1.1e-35 121.2 0.3 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1604) G-patch PF01585.21 MSTRG.21553.1_3 - 6.2e-05 22.7 0.2 0.00014 21.5 0.2 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.5 MSTRG.21553.1_3 - 0.058 13.4 1.6 0.12 12.3 0.3 2.3 2 0 0 2 2 2 0 G-patch domain DUF4695 PF15766.3 MSTRG.25365.7_2 - 0.0047 17.0 7.5 0.2 11.8 0.2 3.0 1 1 0 2 2 2 2 Domain of unknown function (DUF4695) RRM_1 PF00076.20 MSTRG.16576.4_1 - 3.9e-61 202.7 0.0 9.4e-22 76.5 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 MSTRG.16576.4_1 - 1.1e-08 34.6 0.0 0.00022 20.9 0.0 2.6 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_7 PF16367.3 MSTRG.16576.4_1 - 6e-07 29.4 0.1 0.35 10.9 0.0 4.0 3 1 0 3 3 3 2 RNA recognition motif Calcipressin PF04847.10 MSTRG.16576.4_1 - 0.00012 21.8 0.1 0.012 15.3 0.0 2.4 3 0 0 3 3 3 1 Calcipressin Cas_Cas2CT1978 PF09707.8 MSTRG.16576.4_1 - 0.041 13.8 0.0 3.5 7.6 0.0 2.5 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_Cas2CT1978) Neur_chan_memb PF02932.14 MSTRG.9722.2_1 - 2.4e-30 106.2 5.0 1.6e-24 87.2 2.3 2.4 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 MSTRG.9722.2_3 - 1.4e-12 47.4 0.0 2.4e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain zf-C4 PF00105.16 MSTRG.24461.1_1 - 1.6e-29 102.0 16.8 5.8e-29 100.2 16.8 2.1 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 MSTRG.24461.1_1 - 6.9e-19 68.1 0.0 1.5e-18 67.0 0.0 1.5 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor CC2-LZ PF16516.3 MSTRG.17895.1_1 - 0.00084 19.5 14.8 0.00084 19.5 14.8 3.4 2 2 0 2 2 2 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator SelP_N PF04592.12 MSTRG.17895.1_3 - 0.27 10.5 8.5 0.53 9.5 8.5 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region G3P_acyltransf PF02660.13 MSTRG.17895.1_3 - 8.5 6.3 15.3 14 5.5 15.3 1.3 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase Cation_efflux PF01545.19 MSTRG.25581.1_1 - 4.1e-41 140.8 5.5 4.9e-37 127.5 0.6 2.6 3 0 0 3 3 3 2 Cation efflux family ACPS PF01648.18 MSTRG.17043.1_3 - 2.4e-05 24.3 0.0 0.00039 20.4 0.0 2.3 2 1 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily DeoC PF01791.7 MSTRG.17043.1_3 - 0.098 12.1 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 DeoC/LacD family aldolase PTR2 PF00854.19 MSTRG.25292.1_1 - 1.7e-122 409.0 5.4 2.2e-122 408.6 5.4 1.1 1 0 0 1 1 1 1 POT family MFS_2 PF13347.4 MSTRG.25292.1_1 - 0.00026 19.5 7.6 0.00026 19.5 7.6 2.4 2 1 0 2 2 2 1 MFS/sugar transport protein DUF4397 PF14344.4 MSTRG.25292.1_1 - 0.0044 17.7 0.0 0.034 14.8 0.0 2.4 1 1 1 2 2 2 1 Domain of unknown function (DUF4397) PTS_EIIB PF00367.18 MSTRG.466.1_1 - 0.056 12.8 0.0 0.1 12.0 0.0 1.5 1 0 0 1 1 1 0 phosphotransferase system, EIIB Ank_2 PF12796.5 MSTRG.23418.1_2 - 1.4e-45 153.7 0.3 2.3e-13 50.4 0.0 4.2 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.23418.1_2 - 2.7e-44 148.4 0.7 5.3e-11 42.4 0.0 6.5 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_4 PF13637.4 MSTRG.23418.1_2 - 2.6e-41 139.3 0.1 6.3e-09 36.1 0.0 6.4 1 1 6 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.23418.1_2 - 1e-38 129.9 0.0 3.3e-08 33.5 0.0 7.2 7 0 0 7 7 7 6 Ankyrin repeat Ank_3 PF13606.4 MSTRG.23418.1_2 - 1.6e-33 110.8 0.0 5.3e-07 29.3 0.0 6.8 7 0 0 7 7 7 6 Ankyrin repeat UDPG_MGDP_dh_C PF03720.13 MSTRG.23418.1_2 - 0.011 16.0 0.0 8.6 6.7 0.0 3.0 3 1 1 4 4 4 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain PCMT PF01135.17 MSTRG.20441.1_3 - 2e-23 83.1 0.0 2.9e-23 82.6 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) SOCS_box PF07525.14 MSTRG.20441.1_3 - 0.002 18.3 11.4 0.08 13.2 0.8 3.0 3 0 0 3 3 3 2 SOCS box Methyltransf_25 PF13649.4 MSTRG.20441.1_3 - 0.003 18.1 0.0 0.0089 16.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.4 MSTRG.20441.1_3 - 0.0048 16.6 0.0 0.008 15.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.11 MSTRG.20441.1_3 - 0.0078 15.6 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 DDDD PF10161.7 MSTRG.27911.1_1 - 2.1e-33 113.8 0.2 3.6e-33 113.0 0.2 1.3 1 0 0 1 1 1 1 Putative mitochondrial precursor protein Homeobox PF00046.27 MSTRG.26068.1_1 - 1.4e-21 75.9 8.4 2.3e-21 75.2 8.4 1.3 1 0 0 1 1 1 1 Homeobox domain DUF2209 PF09974.7 MSTRG.26068.1_1 - 0.066 13.4 0.1 0.1 12.8 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) LNS2 PF08235.11 MSTRG.8316.1_2 - 6.7e-104 346.2 0.0 1e-103 345.5 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_mid PF16876.3 MSTRG.8316.1_2 - 6.5e-34 116.1 0.1 1.2e-33 115.2 0.1 1.5 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain SH3BGR PF04908.13 MSTRG.4319.6_1 - 2.9e-42 142.7 0.0 4.5e-42 142.1 0.0 1.3 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.22 MSTRG.4319.6_1 - 0.01 15.9 0.0 0.027 14.5 0.0 1.7 1 0 0 1 1 1 0 Glutaredoxin TSC22 PF01166.16 MSTRG.1010.2_1 - 0.092 12.9 0.1 0.092 12.9 0.1 3.2 3 1 1 4 4 4 0 TSC-22/dip/bun family FPP PF05911.9 MSTRG.1010.2_1 - 0.11 10.6 26.5 0.17 10.0 21.7 2.0 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil DUF1192 PF06698.9 MSTRG.1010.2_1 - 0.89 9.5 4.6 18 5.4 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) PKcGMP_CC PF16808.3 MSTRG.1010.2_1 - 6.3 6.6 13.4 12 5.8 1.0 3.5 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ADIP PF11559.6 MSTRG.1010.2_1 - 6.9 6.6 31.2 3.5 7.6 14.5 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding CALCOCO1 PF07888.9 MSTRG.1010.2_1 - 9.1 4.6 28.6 16 3.8 28.6 1.3 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF1246 PF06849.10 MSTRG.4245.1_1 - 0.11 12.4 0.1 6.5 6.6 0.0 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1246) SUI1 PF01253.20 MSTRG.6680.1_1 - 8e-28 96.7 1.5 2e-27 95.4 1.1 1.8 2 0 0 2 2 2 1 Translation initiation factor SUI1 F5_F8_type_C PF00754.23 MSTRG.15829.1_2 - 1.2e-49 167.6 0.6 1.7e-24 86.3 0.1 2.8 2 0 0 2 2 2 2 F5/8 type C domain Cu-oxidase_2 PF07731.12 MSTRG.15829.1_2 - 1.4e-10 41.0 4.3 0.0001 21.9 0.2 4.0 3 0 0 3 3 3 3 Multicopper oxidase Cu-oxidase_3 PF07732.13 MSTRG.15829.1_2 - 6.9e-09 35.6 0.2 7.6e-05 22.6 0.0 4.5 4 1 0 4 4 4 2 Multicopper oxidase Cu-oxidase PF00394.20 MSTRG.15829.1_2 - 5.6e-05 23.2 0.5 0.088 12.8 0.0 3.4 3 0 0 3 3 3 2 Multicopper oxidase Ras PF00071.20 MSTRG.5015.2_2 - 1.1e-58 197.3 0.1 1.5e-58 196.9 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.5015.2_2 - 2.5e-30 105.1 0.0 3.8e-30 104.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.5015.2_2 - 6.6e-11 41.8 0.0 1e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 MSTRG.5015.2_2 - 0.0012 18.8 0.0 0.0023 17.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 MSTRG.5015.2_2 - 0.017 14.6 0.0 0.11 11.9 0.0 2.0 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 MSTRG.5015.2_2 - 0.074 12.3 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF3421 PF11901.6 MSTRG.16203.2_1 - 4e-08 33.2 0.2 2.3e-07 30.7 0.1 2.3 1 1 2 3 3 3 2 Protein of unknown function (DUF3421) ETX_MTX2 PF03318.11 MSTRG.16203.2_1 - 0.014 15.0 3.7 0.026 14.2 3.7 1.4 1 0 0 1 1 1 0 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Sec62 PF03839.14 MSTRG.24811.1_1 - 1.3e-74 250.2 0.4 1.3e-74 250.2 0.4 2.8 1 1 1 2 2 2 1 Translocation protein Sec62 DUF2207 PF09972.7 MSTRG.24811.1_1 - 0.00087 18.1 0.3 0.00087 18.1 0.3 1.6 2 0 0 2 2 2 1 Predicted membrane protein (DUF2207) DEP PF00610.19 MSTRG.24811.1_1 - 0.071 13.0 0.0 0.24 11.3 0.0 1.9 1 0 0 1 1 1 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dsh_C PF12316.6 MSTRG.24811.1_1 - 0.1 12.9 11.5 2 8.7 0.1 2.6 3 0 0 3 3 3 0 Segment polarity protein dishevelled (Dsh) C terminal CDC45 PF02724.12 MSTRG.24811.1_1 - 0.95 7.6 40.1 1.9 6.6 22.5 2.4 2 0 0 2 2 2 0 CDC45-like protein V_ATPase_I PF01496.17 MSTRG.3041.2_1 - 3.3e-19 68.2 0.0 4e-19 67.9 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family BPS PF08947.8 MSTRG.10193.3_3 - 3.7e-17 61.7 0.8 9.8e-17 60.4 0.8 1.8 1 0 0 1 1 1 1 BPS (Between PH and SH2) SH2 PF00017.22 MSTRG.10193.3_3 - 2.2e-13 49.9 0.0 4e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 SH2 domain PH PF00169.27 MSTRG.10193.3_3 - 6.1e-10 39.4 0.2 2.1e-09 37.7 0.0 2.0 2 0 0 2 2 2 1 PH domain RA PF00788.21 MSTRG.10193.3_3 - 8.3e-09 35.8 0.0 1.9e-08 34.7 0.0 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain DEAD PF00270.27 MSTRG.20349.2_2 - 1.6e-53 180.9 0.0 1.4e-52 177.8 0.0 2.2 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.20349.2_2 - 3.7e-31 107.6 0.0 1.2e-30 105.9 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.20349.2_2 - 0.0016 18.3 0.0 0.0042 17.0 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.4 MSTRG.20349.2_2 - 0.0036 17.5 0.0 0.31 11.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain UTP25 PF06862.10 MSTRG.20349.2_2 - 0.058 12.0 0.0 0.15 10.7 0.0 1.6 1 0 0 1 1 1 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DUF3698 PF12479.6 MSTRG.20349.2_2 - 0.23 11.9 1.3 0.61 10.5 1.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3698) Sushi PF00084.18 MSTRG.1762.1_1 - 0.00015 22.2 5.2 0.0002 21.8 0.2 2.6 3 0 0 3 3 3 1 Sushi repeat (SCR repeat) Sushi_2 PF09014.8 MSTRG.1762.1_1 - 0.00039 20.2 0.5 0.00097 18.9 0.1 1.8 1 1 1 2 2 2 1 Beta-2-glycoprotein-1 fifth domain FGE-sulfatase PF03781.14 MSTRG.14104.1_1 - 2.5e-87 292.6 4.4 3.3e-87 292.2 4.4 1.1 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 Ephrin PF00812.15 MSTRG.1646.1_2 - 1.2e-30 106.1 0.1 1.7e-30 105.7 0.1 1.2 1 0 0 1 1 1 1 Ephrin IF4E PF01652.16 MSTRG.6544.1_3 - 0.14 11.8 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic initiation factor 4E Glycos_transf_2 PF00535.24 MSTRG.17377.1_2 - 6.8e-08 32.4 0.1 1.1e-07 31.8 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 IL17_R_N PF15037.4 MSTRG.24655.1_1 - 3.3e-19 69.0 0.1 4.6e-19 68.5 0.1 1.2 1 0 0 1 1 1 1 Interleukin-17 receptor extracellular region SEFIR PF08357.9 MSTRG.24655.1_1 - 2.9e-08 34.0 0.0 7.6e-08 32.6 0.0 1.7 1 1 0 1 1 1 1 SEFIR domain Glycogen_syn PF05693.11 MSTRG.11750.1_3 - 0 1162.2 0.0 0 1161.8 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glyco_transf_5 PF08323.9 MSTRG.11750.1_3 - 1.1e-06 28.4 0.1 2.8e-06 27.1 0.1 1.6 1 0 0 1 1 1 1 Starch synthase catalytic domain Glyco_transf_4 PF13439.4 MSTRG.11750.1_3 - 4.1e-05 23.5 0.1 8.8e-05 22.4 0.1 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.18 MSTRG.11750.1_3 - 0.00044 19.7 0.0 0.0069 15.9 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.4 MSTRG.11750.1_3 - 0.0021 18.3 0.0 0.044 14.1 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferases group 1 NeuB PF03102.12 MSTRG.11463.1_1 - 9.3e-81 270.7 0.1 1.2e-80 270.3 0.1 1.1 1 0 0 1 1 1 1 NeuB family SAF PF08666.10 MSTRG.11463.1_1 - 0.00019 21.9 0.2 0.00035 21.0 0.2 1.5 1 0 0 1 1 1 1 SAF domain DUF2458 PF10454.7 MSTRG.11463.1_1 - 0.084 12.4 0.2 0.14 11.7 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) DUF842 PF05811.11 MSTRG.19467.1_1 - 0.52 10.0 3.3 0.82 9.4 0.1 2.1 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF842) Ribosomal_L3 PF00297.20 MSTRG.19467.1_2 - 3.6e-189 628.2 11.4 4.1e-189 628.0 11.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 IL17 PF06083.9 MSTRG.1457.1_1 - 6.5e-28 96.9 3.1 9.9e-28 96.3 3.1 1.3 1 0 0 1 1 1 1 Interleukin-17 EutK_C PF16365.3 MSTRG.1237.1_1 - 0.58 10.1 3.7 1.1 9.2 3.7 1.4 1 0 0 1 1 1 0 Ethanolamine utilization protein EutK C-terminus NYAP_N PF15439.4 MSTRG.16232.1_1 - 1.2e-112 376.9 31.5 2.4e-112 375.9 31.5 1.5 1 0 0 1 1 1 1 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter Myosin_head PF00063.19 MSTRG.16232.1_1 - 1.2e-20 73.3 0.0 1.4e-20 73.0 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.25 MSTRG.16232.1_1 - 0.0028 17.2 1.6 0.0071 15.9 1.6 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif Mo25 PF08569.9 MSTRG.12485.1_1 - 2.4e-141 470.7 12.8 3.2e-141 470.3 12.8 1.2 1 0 0 1 1 1 1 Mo25-like MBOAT PF03062.17 MSTRG.27000.1_3 - 5.3e-43 147.6 38.1 1.5e-42 146.1 38.1 1.7 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.4 MSTRG.27000.1_3 - 3.4 7.9 12.3 0.5 10.6 4.8 3.1 3 0 0 3 3 3 0 Membrane bound O-acyl transferase family zf-H2C2_2 PF13465.4 MSTRG.12265.1_1 - 1.3e-09 37.9 13.3 1.4e-06 28.3 4.9 4.7 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.12265.1_1 - 2.2e-09 37.1 42.3 5.1e-05 23.4 4.1 4.3 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.12265.1_1 - 0.0012 19.4 38.6 0.011 16.4 3.5 4.9 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.5 MSTRG.12265.1_1 - 0.016 15.4 9.1 0.43 10.9 1.3 2.9 2 0 0 2 2 2 0 Zinc-finger of C2H2 type OATP PF03137.18 MSTRG.5206.1_3 - 3.7e-183 609.6 13.8 5.5e-183 609.0 13.8 1.3 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 MSTRG.5206.1_3 - 1.1e-23 83.6 27.3 3.4e-23 82.0 17.4 3.1 3 1 0 3 3 3 2 Major Facilitator Superfamily Kazal_2 PF07648.13 MSTRG.5206.1_3 - 2.2e-08 34.0 4.9 4.9e-08 32.9 4.9 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 MSTRG.5206.1_3 - 4.1e-05 23.4 3.9 0.00015 21.5 3.9 2.0 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain NfeD PF01957.16 MSTRG.5206.1_3 - 9.8 6.4 6.2 4.5 7.6 0.0 3.0 3 0 0 3 3 3 0 NfeD-like C-terminal, partner-binding Glyco_hydro_18 PF00704.26 MSTRG.24643.1_2 - 4e-20 72.6 0.1 4.7e-20 72.4 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Sirohm_synth_C PF14823.4 MSTRG.12257.1_1 - 0.058 12.9 0.1 0.1 12.1 0.1 1.3 1 0 0 1 1 1 0 Sirohaem biosynthesis protein C-terminal TRAPP PF04051.14 MSTRG.6094.1_2 - 5.4e-37 126.6 0.0 7.3e-37 126.2 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component uDENN PF03456.16 MSTRG.18447.1_2 - 8.2e-10 39.2 0.1 2e-09 38.0 0.1 1.7 1 0 0 1 1 1 1 uDENN domain SR-25 PF10500.7 MSTRG.18447.1_2 - 1.1 8.7 7.0 1.7 8.1 7.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PSI PF01437.23 MSTRG.18275.2_1 - 0.00025 21.4 9.2 0.0005 20.4 9.2 1.4 1 0 0 1 1 1 1 Plexin repeat zf-H2C2_2 PF13465.4 MSTRG.8420.1_2 - 4.6e-28 96.3 26.8 4.2e-10 39.5 0.5 6.2 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.8420.1_2 - 2.5e-16 59.0 52.1 1.2e-05 25.4 1.1 5.9 6 0 0 6 6 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.8420.1_2 - 5.2e-10 39.2 48.8 0.00045 20.7 1.9 5.5 6 0 0 6 6 4 4 C2H2-type zinc finger zf-met PF12874.5 MSTRG.8420.1_2 - 7.7e-08 32.4 21.3 0.0029 17.8 0.7 5.0 5 0 0 5 5 4 3 Zinc-finger of C2H2 type zf-Di19 PF05605.10 MSTRG.8420.1_2 - 1.2e-06 28.6 19.4 0.0004 20.5 3.2 3.3 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.4 MSTRG.8420.1_2 - 3.6e-05 23.5 26.6 0.018 14.9 0.3 5.9 5 1 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.8420.1_2 - 4.4e-05 23.5 12.1 0.14 12.3 0.1 4.4 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-Sec23_Sec24 PF04810.13 MSTRG.8420.1_2 - 0.0094 15.8 8.9 4.4 7.3 0.1 4.6 3 1 1 4 4 4 1 Sec23/Sec24 zinc finger Caldesmon PF02029.13 MSTRG.8420.1_2 - 0.012 14.3 4.6 0.018 13.7 4.6 1.1 1 0 0 1 1 1 0 Caldesmon zf-C2H2_2 PF12756.5 MSTRG.8420.1_2 - 0.017 15.3 19.0 4.7 7.5 1.4 5.0 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.8 MSTRG.8420.1_2 - 0.14 12.2 16.3 0.067 13.2 1.0 4.0 4 0 0 4 4 3 0 Zinc ribbon domain ADK_lid PF05191.12 MSTRG.8420.1_2 - 0.21 11.5 3.4 12 5.9 0.4 3.3 1 1 2 3 3 3 0 Adenylate kinase, active site lid SKA1 PF07160.10 MSTRG.8420.1_2 - 0.29 10.8 5.7 0.47 10.1 5.7 1.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 LIM PF00412.20 MSTRG.8420.1_2 - 0.41 10.8 18.3 2.5 8.3 0.5 4.6 3 1 2 5 5 5 0 LIM domain Zn_Tnp_IS1595 PF12760.5 MSTRG.8420.1_2 - 0.63 9.9 17.9 0.28 11.0 4.5 3.3 2 1 1 3 3 3 0 Transposase zinc-ribbon domain CpXC PF14353.4 MSTRG.8420.1_2 - 2.1 8.3 11.5 2.8 7.8 0.2 4.4 1 1 1 3 3 3 0 CpXC protein DUF2225 PF09986.7 MSTRG.8420.1_2 - 2.5 7.7 11.2 1.3 8.5 1.6 3.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) Elf1 PF05129.11 MSTRG.8420.1_2 - 4 7.4 19.6 5.8 6.9 3.4 3.9 2 1 2 4 4 4 0 Transcription elongation factor Elf1 like zf-CHCC PF10276.7 MSTRG.8420.1_2 - 4.2 7.4 6.5 50 3.9 0.0 3.8 4 0 0 4 4 4 0 Zinc-finger domain TerY_C PF15616.4 MSTRG.8420.1_2 - 8.7 6.4 10.0 0.68 9.9 1.3 2.9 2 1 1 3 3 3 0 TerY-C metal binding domain DUF2256 PF10013.7 MSTRG.8420.1_2 - 9.4 6.3 14.5 23 5.1 0.2 4.3 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) Tetraspannin PF00335.18 MSTRG.2386.1_3 - 1.1e-44 152.6 14.3 1.4e-44 152.3 14.3 1.1 1 0 0 1 1 1 1 Tetraspanin family CD20 PF04103.13 MSTRG.2386.1_3 - 0.0056 16.6 2.6 0.0056 16.6 2.6 2.1 1 1 1 2 2 2 1 CD20-like family NfeD PF01957.16 MSTRG.2386.1_3 - 0.06 13.6 0.3 0.06 13.6 0.3 2.2 3 0 0 3 3 3 0 NfeD-like C-terminal, partner-binding SUR7 PF06687.10 MSTRG.2386.1_3 - 0.8 9.2 12.6 0.096 12.2 2.7 2.8 3 0 0 3 3 3 0 SUR7/PalI family EphA2_TM PF14575.4 MSTRG.2386.1_3 - 5.6 7.7 6.8 23 5.8 0.0 3.2 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain PP2C PF00481.19 MSTRG.26092.1_1 - 1.8e-66 224.2 0.0 3.2e-66 223.5 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.4 MSTRG.26092.1_1 - 0.043 13.3 0.3 0.043 13.3 0.3 1.9 3 1 0 3 3 3 0 Protein phosphatase 2C Transmemb_17 PF09799.7 MSTRG.26092.1_2 - 0.04 14.4 0.4 0.065 13.7 0.4 1.3 1 0 0 1 1 1 0 Predicted membrane protein PDZ_2 PF13180.4 MSTRG.25843.1_1 - 0.0019 18.3 0.0 0.0041 17.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.22 MSTRG.25843.1_1 - 0.015 15.5 0.0 0.03 14.6 0.0 1.4 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) Tricorn_PDZ PF14685.4 MSTRG.25843.1_1 - 0.059 13.3 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 Tricorn protease PDZ domain Trypsin PF00089.24 MSTRG.19531.1_3 - 6.5e-34 117.5 0.0 8.5e-34 117.2 0.0 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 MSTRG.19531.1_3 - 5.5e-07 29.8 0.0 8.5e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 MSTRG.19531.1_3 - 0.011 16.5 0.0 0.017 15.8 0.0 1.3 1 0 0 1 1 1 0 Trypsin-like peptidase domain UCH PF00443.27 MSTRG.25483.2_1 - 5.6e-26 91.5 0.0 9.7e-26 90.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.27 MSTRG.25483.2_2 - 5.8e-12 45.5 0.0 5.8e-12 45.5 0.0 1.5 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 MSTRG.25483.2_2 - 0.00056 19.5 1.1 0.00099 18.7 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UIM PF02809.18 MSTRG.25483.2_2 - 0.0013 18.4 1.3 0.0013 18.4 1.3 3.3 3 0 0 3 3 3 2 Ubiquitin interaction motif UBA_4 PF14555.4 MSTRG.25483.2_2 - 0.012 15.2 0.3 0.012 15.2 0.3 1.9 3 0 0 3 3 3 0 UBA-like domain PhnI PF05861.10 MSTRG.25483.2_2 - 0.087 11.5 0.9 0.13 11.0 0.9 1.1 1 0 0 1 1 1 0 Bacterial phosphonate metabolism protein (PhnI) Annexin PF00191.18 MSTRG.2859.1_2 - 1.9e-93 306.4 16.3 2.5e-26 91.4 0.9 4.2 4 0 0 4 4 4 4 Annexin UBA_2 PF08587.9 MSTRG.2859.1_2 - 0.0028 17.6 1.2 0.23 11.5 0.3 2.8 2 0 0 2 2 2 2 Ubiquitin associated domain (UBA) YlbE PF14003.4 MSTRG.2859.1_2 - 0.32 11.3 1.5 6.4 7.2 0.2 2.5 2 0 0 2 2 2 0 YlbE-like protein RPE65 PF03055.13 MSTRG.3893.1_3 - 6.2e-114 381.3 0.2 8.1e-114 380.9 0.2 1.1 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein 2OG-FeII_Oxy_3 PF13640.4 MSTRG.6974.1_2 - 2.9e-11 43.9 0.0 5.6e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.18 MSTRG.6974.1_2 - 0.0001 22.6 0.0 0.00027 21.2 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily I-set PF07679.14 MSTRG.27107.1_2 - 7.7e-07 29.0 0.0 1.2e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.15 MSTRG.27107.1_2 - 0.0004 20.4 0.1 0.00072 19.6 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 MSTRG.27107.1_2 - 0.0058 17.1 0.1 0.011 16.2 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Bile_Hydr_Trans PF04775.12 MSTRG.14511.2_1 - 3e-23 82.1 0.0 4.4e-23 81.5 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA thioester hydrolase/BAAT N-terminal region BAAT_C PF08840.9 MSTRG.14511.2_2 - 1.2e-54 185.4 0.0 1.5e-54 185.0 0.0 1.2 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.16 MSTRG.14511.2_2 - 1.4e-07 31.1 0.1 1e-05 25.1 0.0 2.5 2 1 0 2 2 2 1 Dienelactone hydrolase family Bile_Hydr_Trans PF04775.12 MSTRG.14511.2_2 - 2.3e-07 30.7 0.0 4.3e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA thioester hydrolase/BAAT N-terminal region Peptidase_S9 PF00326.19 MSTRG.14511.2_2 - 2.5e-06 27.0 0.0 5.8e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.6 MSTRG.14511.2_2 - 0.16 11.1 0.2 1.2 8.2 0.0 2.2 3 0 0 3 3 3 0 Serine aminopeptidase, S33 Urb2 PF10441.7 MSTRG.23228.1_2 - 2.7e-18 66.5 2.1 2.7e-18 66.5 2.1 4.3 5 1 0 5 5 5 1 Urb2/Npa2 family Peptidase_C48 PF02902.17 MSTRG.22389.1_2 - 2.1e-32 112.6 0.9 3.7e-32 111.8 0.9 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Lectin_C PF00059.19 MSTRG.2245.2_2 - 8.8e-155 505.6 47.0 4.2e-21 75.6 2.4 8.5 8 0 0 8 8 8 8 Lectin C-type domain fn2 PF00040.17 MSTRG.2245.2_2 - 5.2e-17 61.7 6.9 2.8e-16 59.4 6.9 2.5 1 0 0 1 1 1 1 Fibronectin type II domain Xlink PF00193.15 MSTRG.2245.2_2 - 1.8e-08 34.5 10.3 0.39 11.0 0.1 7.8 8 0 0 8 8 8 3 Extracellular link domain Chordopox_A33R PF05966.10 MSTRG.2245.2_2 - 2.8e-06 26.6 5.2 0.0065 15.6 0.0 5.2 6 0 0 6 6 6 2 Chordopoxvirus A33R protein Ricin_B_lectin PF00652.20 MSTRG.2245.2_2 - 1.5e-05 25.1 0.8 1.5e-05 25.1 0.8 2.2 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain UL45 PF05473.10 MSTRG.2245.2_2 - 0.00017 21.1 14.8 0.054 13.0 0.2 6.3 7 2 0 7 7 7 2 UL45 protein, carbohydrate-binding C-type lectin-like fn3 PF00041.19 MSTRG.17508.3_1 - 3.6e-249 805.9 72.4 6.2e-20 71.2 0.5 17.4 17 0 0 17 17 17 17 Fibronectin type III domain fn1 PF00039.16 MSTRG.17508.3_1 - 3.5e-140 455.8 155.9 2.1e-15 56.5 5.0 12.7 12 0 0 12 12 12 12 Fibronectin type I domain DUF2369 PF10179.7 MSTRG.17508.3_1 - 1.1e-31 109.0 10.6 0.1 12.9 0.0 14.6 17 0 0 17 17 15 7 Uncharacterised conserved protein (DUF2369) fn2 PF00040.17 MSTRG.17508.3_1 - 2.5e-30 104.3 30.3 1.4e-17 63.5 7.5 3.6 3 0 0 3 3 2 2 Fibronectin type II domain Pur_ac_phosph_N PF16656.3 MSTRG.17508.3_1 - 7.8e-25 87.2 49.7 0.16 12.4 0.1 18.4 15 4 0 15 15 15 7 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 MSTRG.17508.3_1 - 2.5e-15 56.5 0.0 0.12 12.6 0.0 12.9 16 0 0 16 16 15 2 Interferon-alpha/beta receptor, fibronectin type III Glyco_hydro_66 PF13199.4 MSTRG.17508.3_1 - 0.00047 18.8 0.1 0.27 9.7 0.0 4.0 3 0 0 3 3 3 1 Glycosyl hydrolase family 66 DUF1410 PF07198.9 MSTRG.17508.3_1 - 0.00069 20.0 0.6 53 4.3 0.1 6.1 6 0 0 6 6 6 0 Protein of unknown function (DUF1410) fn3_2 PF16893.3 MSTRG.17508.3_1 - 0.0015 18.5 0.0 26 4.9 0.0 7.1 10 0 0 10 10 9 0 Fibronectin type III domain DUF4945 PF16303.3 MSTRG.17508.3_1 - 0.029 14.2 0.4 0.62 9.9 0.0 3.5 4 1 1 5 5 5 0 Domain of unknown function (DUF4945) DUF4493 PF14900.4 MSTRG.17508.3_1 - 0.036 14.0 5.3 0.4 10.6 0.5 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4493) CBM_4_9 PF02018.15 MSTRG.17508.3_1 - 0.16 12.0 7.4 19 5.4 0.3 5.9 5 1 1 6 6 6 0 Carbohydrate binding domain Phage_H_T_join PF05521.9 MSTRG.17508.3_1 - 1.4 9.3 4.0 82 3.7 0.1 5.1 6 0 0 6 6 6 0 Phage head-tail joining protein CD99L2 PF12301.6 MSTRG.6277.1_1 - 2.8e-46 157.7 12.8 1e-45 155.9 12.8 1.7 1 1 0 1 1 1 1 CD99 antigen like protein 2 Pro-rich_19 PF15455.4 MSTRG.23327.1_1 - 1.1e-05 24.7 10.2 1.1e-05 24.7 10.2 3.7 3 1 0 3 3 3 2 Proline-rich 19 Pkinase PF00069.23 MSTRG.5486.1_1 - 0.015 14.5 0.0 0.019 14.2 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain zf-C2H2 PF00096.24 MSTRG.17196.1_1 - 2.9e-19 68.2 92.1 0.0033 17.7 1.7 11.6 11 0 0 11 11 11 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.17196.1_1 - 9.1e-15 54.0 85.6 0.0078 16.8 1.3 11.7 11 0 0 11 11 11 9 C2H2-type zinc finger zf-H2C2_2 PF13465.4 MSTRG.17196.1_1 - 1e-05 25.6 0.9 1e-05 25.6 0.9 10.6 11 1 0 11 11 11 2 Zinc-finger double domain zf-C2H2_11 PF16622.3 MSTRG.17196.1_1 - 2.6e-05 23.7 58.5 0.02 14.5 1.3 10.2 10 0 0 10 10 10 5 zinc-finger C2H2-type zf-C2HC_2 PF13913.4 MSTRG.17196.1_1 - 0.0062 16.3 4.0 0.0062 16.3 4.0 5.2 4 0 0 4 4 4 1 zinc-finger of a C2HC-type zf-met PF12874.5 MSTRG.17196.1_1 - 0.014 15.6 56.6 0.14 12.4 2.5 9.2 9 0 0 9 9 9 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.17196.1_1 - 0.17 12.1 55.1 3.6 7.9 0.4 10.9 11 0 0 11 11 11 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 MSTRG.17196.1_1 - 1.3 8.9 72.5 0.025 14.4 1.9 10.8 11 0 0 11 11 11 0 C2H2-type zinc finger Ig_3 PF13927.4 MSTRG.4318.3_1 - 2.8e-08 34.1 0.0 0.013 16.0 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 MSTRG.4318.3_1 - 0.00069 19.5 0.0 0.033 14.1 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin I-set domain SIT PF15330.4 MSTRG.4318.3_2 - 0.047 14.0 0.0 0.089 13.1 0.0 1.3 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Y_phosphatase PF00102.25 MSTRG.3423.1_1 - 7.8e-167 552.4 0.5 4.6e-83 278.2 0.0 2.3 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.18 MSTRG.3423.1_1 - 3.4e-08 33.2 0.0 0.0065 16.2 0.0 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 MSTRG.3423.1_1 - 3.1e-07 30.4 0.0 0.021 14.6 0.0 2.2 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.4 MSTRG.3423.1_1 - 1.4e-05 25.1 0.0 0.0062 16.6 0.0 2.6 2 0 0 2 2 2 2 Inositol hexakisphosphate Glyco_hydro_46 PF01374.16 MSTRG.3423.1_1 - 0.043 13.3 0.0 0.075 12.5 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 46 PH_13 PF16652.3 MSTRG.8312.2_3 - 1.1e-60 203.9 0.0 1.1e-60 203.9 0.0 3.9 3 1 1 4 4 1 1 Pleckstrin homology domain RhoGEF PF00621.18 MSTRG.8312.2_3 - 7.2e-45 153.3 0.5 7.2e-45 153.3 0.5 2.2 2 0 0 2 2 2 1 RhoGEF domain SH3_9 PF14604.4 MSTRG.8312.2_3 - 1.9e-42 142.8 5.7 3.7e-16 58.6 0.1 4.7 5 0 0 5 5 5 4 Variant SH3 domain SH3_1 PF00018.26 MSTRG.8312.2_3 - 4.8e-38 128.4 4.9 2.6e-14 52.4 0.1 4.5 4 0 0 4 4 4 4 SH3 domain SH3_2 PF07653.15 MSTRG.8312.2_3 - 1.1e-37 127.3 0.2 5.1e-12 45.2 0.0 4.4 4 0 0 4 4 4 4 Variant SH3 domain EF-hand_4 PF12763.5 MSTRG.8312.2_3 - 7.7e-28 96.4 0.0 4.6e-13 48.9 0.0 2.6 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand C2 PF00168.28 MSTRG.8312.2_3 - 1e-20 73.8 0.0 3.7e-20 72.0 0.0 2.0 2 0 0 2 2 2 1 C2 domain EF-hand_1 PF00036.30 MSTRG.8312.2_3 - 1.7e-10 39.5 1.5 6.7e-05 22.0 0.2 3.4 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.4 MSTRG.8312.2_3 - 1.8e-09 37.8 0.0 4.5e-05 23.7 0.0 3.1 2 0 0 2 2 2 2 EF-hand domain pair MIP-T3 PF10243.7 MSTRG.8312.2_3 - 6.4e-09 35.0 31.7 6.4e-09 35.0 31.7 2.3 2 0 0 2 2 2 1 Microtubule-binding protein MIP-T3 EF-hand_6 PF13405.4 MSTRG.8312.2_3 - 2.8e-08 32.9 1.2 0.15 12.0 0.1 4.0 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.4 MSTRG.8312.2_3 - 0.0014 18.0 1.2 0.096 12.1 0.2 2.9 2 0 0 2 2 2 1 EF hand 6PF2K PF01591.16 MSTRG.20331.1_2 - 3.5e-102 340.3 1.5 5.5e-102 339.7 1.5 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.20 MSTRG.20331.1_2 - 2.7e-39 134.8 0.0 4e-39 134.2 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.4 MSTRG.20331.1_2 - 2.2e-06 27.8 0.0 4.2e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.8 MSTRG.20331.1_2 - 0.0011 18.3 0.2 0.0017 17.7 0.2 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 His_Phos_2 PF00328.20 MSTRG.20331.1_2 - 0.022 14.0 0.0 0.035 13.3 0.0 1.2 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) Peptidase_C65 PF10275.7 MSTRG.3293.1_1 - 1.2e-81 273.6 0.8 1.8e-81 273.1 0.8 1.2 1 0 0 1 1 1 1 Peptidase C65 Otubain Ig_3 PF13927.4 MSTRG.3293.1_1 - 3.3e-16 59.5 1.2 2.5e-08 34.3 0.0 4.0 4 0 0 4 4 4 2 Immunoglobulin domain V-set PF07686.15 MSTRG.3293.1_1 - 2.2e-14 53.4 0.0 6.7e-10 39.0 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_2 PF13895.4 MSTRG.3293.1_1 - 2.1e-11 43.9 0.3 7e-07 29.4 0.0 4.1 5 1 0 5 5 4 2 Immunoglobulin domain I-set PF07679.14 MSTRG.3293.1_1 - 6.5e-10 38.8 0.0 7e-05 22.7 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.23 MSTRG.3293.1_1 - 1.2e-08 34.8 0.0 0.0011 18.9 0.0 3.4 2 1 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 MSTRG.3293.1_1 - 3.7e-07 30.0 1.1 0.00064 19.6 0.0 3.0 3 0 0 3 3 2 2 CD80-like C2-set immunoglobulin domain OTU PF02338.17 MSTRG.3293.1_1 - 6e-05 23.4 0.0 0.017 15.5 0.0 3.3 3 0 0 3 3 3 1 OTU-like cysteine protease IncA PF04156.12 MSTRG.3293.1_1 - 0.0021 17.7 2.0 0.0093 15.6 0.1 2.3 2 0 0 2 2 2 1 IncA protein FAM176 PF14851.4 MSTRG.3293.1_1 - 0.0029 17.2 1.8 0.0043 16.6 0.1 2.1 2 0 0 2 2 2 1 FAM176 family DUF1049 PF06305.9 MSTRG.3293.1_1 - 0.0033 17.1 0.2 0.0076 15.9 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1049) LST1 PF05083.11 MSTRG.3293.1_1 - 0.0035 17.5 0.3 0.014 15.5 0.0 2.2 2 0 0 2 2 2 1 LST-1 protein TMEM154 PF15102.4 MSTRG.3293.1_1 - 0.014 15.2 0.2 0.028 14.2 0.2 1.4 1 0 0 1 1 1 0 TMEM154 protein family Lectin_N PF03954.12 MSTRG.3293.1_1 - 0.015 14.9 0.2 0.042 13.5 0.2 1.7 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain EphA2_TM PF14575.4 MSTRG.3293.1_1 - 0.018 15.7 0.2 0.046 14.4 0.2 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF1191 PF06697.10 MSTRG.3293.1_1 - 0.13 11.4 0.1 0.22 10.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) Lipoprotein_7 PF01540.14 MSTRG.3293.1_1 - 1.2 8.3 3.8 0.22 10.6 0.2 1.5 2 0 0 2 2 2 0 Adhesin lipoprotein TPR_2 PF07719.15 MSTRG.5662.1_2 - 2e-11 42.9 1.1 0.0059 16.5 0.0 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.5662.1_2 - 1e-09 37.7 0.1 0.0026 17.4 0.0 4.0 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.5662.1_2 - 1.8e-07 31.2 4.9 0.064 13.4 0.0 5.1 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.5662.1_2 - 6.5e-06 25.7 0.2 0.017 15.0 0.0 4.9 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.5662.1_2 - 2e-05 24.2 0.0 1.1 9.1 0.0 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.5662.1_2 - 0.00017 21.4 0.1 0.46 10.7 0.0 5.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.5662.1_2 - 0.0017 18.9 0.6 1.3 9.6 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.5662.1_2 - 0.0025 18.2 0.0 1.2 9.8 0.0 4.1 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_4 PF07721.12 MSTRG.5662.1_2 - 0.0089 16.4 0.6 1.4 9.6 0.1 3.5 3 0 0 3 3 2 1 Tetratricopeptide repeat Cohesin_load PF10345.7 MSTRG.5662.1_2 - 0.019 13.3 0.2 1.8 6.7 0.1 2.2 2 0 0 2 2 2 0 Cohesin loading factor PPR_2 PF13041.4 MSTRG.5662.1_2 - 0.047 13.8 0.0 0.29 11.2 0.0 2.2 2 0 0 2 2 2 0 PPR repeat family ANAPC3 PF12895.5 MSTRG.5662.1_2 - 3.4 7.8 5.3 8.7 6.5 0.1 3.7 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 2-Hacid_dh_C PF02826.17 MSTRG.26505.2_1 - 2.1e-54 183.4 0.0 3e-54 182.9 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.28 MSTRG.26505.2_1 - 4e-28 97.6 0.0 5.3e-28 97.2 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.13 MSTRG.26505.2_1 - 0.0039 17.2 0.0 0.0069 16.4 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase MtrG PF04210.11 MSTRG.9950.1_2 - 0.17 11.6 0.0 0.38 10.5 0.0 1.5 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G Tmemb_cc2 PF10267.7 MSTRG.14458.2_2 - 6.4e-58 196.7 0.8 8.9e-58 196.2 0.8 1.1 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein 7TMR-HDED PF07697.9 MSTRG.14458.2_2 - 0.019 14.9 0.7 0.026 14.5 0.7 1.2 1 0 0 1 1 1 0 7TM-HD extracellular Phage_GPO PF05929.9 MSTRG.14458.2_2 - 0.022 14.3 1.6 0.034 13.7 1.6 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF2120 PF09893.7 MSTRG.14458.2_2 - 0.054 13.5 2.1 0.081 12.9 2.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) Allexi_40kDa PF05549.9 MSTRG.14458.2_2 - 0.08 12.3 1.1 0.11 11.8 1.1 1.3 1 0 0 1 1 1 0 Allexivirus 40kDa protein Ribophorin_I PF04597.12 MSTRG.14458.2_2 - 0.16 11.0 1.6 0.22 10.5 1.6 1.1 1 0 0 1 1 1 0 Ribophorin I Bap31 PF05529.10 MSTRG.14458.2_2 - 5.9 6.3 7.2 8.5 5.8 7.2 1.3 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like DUF1977 PF09320.9 MSTRG.27641.1_3 - 7.7e-27 93.5 3.1 1.5e-26 92.6 3.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.29 MSTRG.27641.1_3 - 1.1e-26 92.6 0.9 2.3e-26 91.5 0.9 1.6 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.15 MSTRG.27641.1_3 - 0.0035 17.2 0.4 0.024 14.6 0.3 2.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.27641.1_3 - 0.05 13.3 0.5 1.7 8.5 0.4 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat Laminin_N PF00055.15 MSTRG.12746.1_1 - 3.2e-20 72.6 0.0 3.8e-20 72.4 0.0 1.1 1 0 0 1 1 1 1 Laminin N-terminal (Domain VI) Ribosomal_L7Ae PF01248.24 MSTRG.8725.1_1 - 5e-24 83.7 0.2 1.5e-23 82.2 0.1 1.9 2 0 0 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family HSP70 PF00012.18 MSTRG.3323.2_2 - 0.18 9.8 0.0 0.24 9.4 0.0 1.2 1 0 0 1 1 1 0 Hsp70 protein Dynactin_p62 PF05502.11 MSTRG.7339.1_3 - 2.4e-36 125.4 24.4 1.6e-21 76.5 14.3 2.5 1 1 1 2 2 2 2 Dynactin p62 family FAST_2 PF08368.10 MSTRG.14954.2_3 - 1.8e-21 76.6 0.0 4.8e-21 75.3 0.0 1.8 1 0 0 1 1 1 1 FAST kinase-like protein, subdomain 2 FAST_1 PF06743.13 MSTRG.14954.2_3 - 1.4e-14 53.6 3.3 1.6e-14 53.5 0.1 2.7 3 0 0 3 3 3 1 FAST kinase-like protein, subdomain 1 RAP PF08373.8 MSTRG.14954.2_3 - 7.2e-14 51.5 0.5 1.7e-13 50.3 0.5 1.7 1 0 0 1 1 1 1 RAP domain Spectrin PF00435.19 MSTRG.7672.2_3 - 1.8e-172 561.8 267.2 3.5e-17 62.7 7.5 25.7 26 0 0 26 26 26 22 Spectrin repeat GAS2 PF02187.15 MSTRG.7672.2_3 - 1.8e-30 104.7 0.2 5.3e-30 103.2 0.2 1.9 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain EF-hand_1 PF00036.30 MSTRG.7672.2_3 - 4.1e-12 44.6 1.4 0.00012 21.2 0.4 3.1 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 MSTRG.7672.2_3 - 8.7e-11 40.7 0.9 0.00081 19.0 0.0 3.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.4 MSTRG.7672.2_3 - 1.6e-10 41.2 0.6 1.6e-09 37.9 0.6 3.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.7672.2_3 - 2.3e-08 33.1 2.9 2.8e-05 23.3 0.7 3.0 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.4 MSTRG.7672.2_3 - 1.1e-06 28.1 0.5 8e-06 25.4 0.1 2.6 1 1 1 2 2 2 2 EF-hand domain pair MitMem_reg PF13012.4 MSTRG.7672.2_3 - 0.0091 16.3 0.5 0.0091 16.3 0.5 7.4 6 2 0 6 6 6 1 Maintenance of mitochondrial structure and function DUF192 PF02643.13 MSTRG.7672.2_3 - 0.095 12.7 0.1 3.8 7.6 0.0 2.6 2 0 0 2 2 2 0 Uncharacterized ACR, COG1430 DNA_repr_REX1B PF14966.4 MSTRG.7672.2_3 - 0.59 10.7 22.7 5.8 7.5 0.0 7.0 6 1 0 6 6 6 0 DNA repair REX1-B DUF725 PF05267.10 MSTRG.7672.2_3 - 1.2 9.0 4.5 23 4.8 0.0 4.7 3 0 0 3 3 3 0 Protein of unknown function (DUF725) Ssl1 PF04056.12 MSTRG.260.1_1 - 8.3e-88 293.1 0.2 1.2e-87 292.6 0.2 1.2 1 0 0 1 1 1 1 Ssl1-like VWA_2 PF13519.4 MSTRG.260.1_1 - 1e-14 55.0 0.0 5e-14 52.7 0.0 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain C1_4 PF07975.10 MSTRG.260.1_1 - 6.6e-09 35.8 21.1 6.7e-09 35.8 17.0 2.6 2 0 0 2 2 2 1 TFIIH C1-like domain VWA PF00092.26 MSTRG.260.1_1 - 3.5e-06 27.3 0.0 5e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain DZR PF12773.5 MSTRG.260.1_1 - 0.011 15.6 19.7 11 6.0 18.6 3.2 1 1 1 2 2 2 0 Double zinc ribbon IBR PF01485.19 MSTRG.260.1_1 - 0.55 10.4 17.0 0.11 12.6 12.0 2.4 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain zf-RING_4 PF14570.4 MSTRG.260.1_1 - 1.2 8.8 17.5 4.5 6.9 13.4 2.6 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zinc_ribbon_4 PF13717.4 MSTRG.260.1_1 - 5.6 6.8 12.1 7.3 6.5 0.3 3.4 3 0 0 3 3 3 0 zinc-ribbon domain CREPT PF16566.3 MSTRG.6294.2_2 - 1e-62 210.5 3.9 1e-62 210.5 3.9 2.1 2 1 0 2 2 2 1 Cell-cycle alteration and expression-elevated protein in tumour CTD_bind PF04818.11 MSTRG.6294.2_2 - 7.5e-21 74.6 1.5 3.1e-20 72.6 0.1 2.7 3 0 0 3 3 3 1 RNA polymerase II-binding domain. CTK3 PF12243.6 MSTRG.6294.2_2 - 0.0021 17.9 0.2 0.0048 16.8 0.2 1.6 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 Takusan PF04822.11 MSTRG.6294.2_2 - 4.7 7.0 9.1 2.1 8.2 0.8 3.4 3 0 0 3 3 3 0 Takusan Gelsolin PF00626.20 MSTRG.11869.1_1 - 4.2e-59 196.3 5.3 9.5e-15 54.1 0.0 6.7 6 0 0 6 6 6 6 Gelsolin repeat LRR_8 PF13855.4 MSTRG.11869.1_1 - 3.9e-38 128.9 46.3 5.5e-09 35.5 9.2 7.2 5 2 2 7 7 7 7 Leucine rich repeat LRR_4 PF12799.5 MSTRG.11869.1_1 - 3.3e-22 78.0 58.5 4.3e-05 23.6 2.6 9.2 6 2 2 8 8 8 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 MSTRG.11869.1_1 - 0.00089 18.7 20.4 0.43 9.9 1.0 4.3 1 1 3 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.31 MSTRG.11869.1_1 - 0.02 15.2 43.3 4.2 8.1 0.2 11.9 13 0 0 13 13 13 0 Leucine Rich Repeat LRR_5 PF13306.4 MSTRG.11869.1_1 - 0.063 13.1 0.3 1.2 9.0 0.2 2.7 3 0 0 3 3 3 0 Leucine rich repeats (6 copies) CNH PF00780.20 MSTRG.15933.1_2 - 4.9e-55 186.9 0.0 7e-55 186.4 0.0 1.2 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.23 MSTRG.15933.1_2 - 6.8e-42 143.5 0.0 1.2e-41 142.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.15933.1_2 - 2.5e-31 108.8 0.0 4e-31 108.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.15933.1_2 - 0.00075 18.8 0.0 0.0014 17.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like C2 PF00168.28 MSTRG.16676.2_2 - 1.4e-54 182.5 0.9 5.1e-24 84.4 0.0 4.1 4 0 0 4 4 4 4 C2 domain CEP76-C2 PF15627.4 MSTRG.16676.2_2 - 0.061 12.8 0.0 0.13 11.7 0.0 1.6 1 0 0 1 1 1 0 CEP76 C2 domain HrcA PF01628.19 MSTRG.16676.2_2 - 0.11 12.2 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 HrcA protein C terminal domain XRN_N PF03159.16 MSTRG.7066.3_3 - 3e-95 318.1 0.0 5.8e-95 317.2 0.0 1.5 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus LMWPc PF01451.19 MSTRG.9655.1_2 - 5.2e-47 159.7 0.0 7.8e-47 159.1 0.0 1.3 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase DUF2543 PF10820.6 MSTRG.9655.1_2 - 0.017 15.2 0.0 0.029 14.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2543) Ham1p_like PF01725.14 MSTRG.23788.1_2 - 4.7e-49 166.4 0.0 6.1e-49 166.0 0.0 1.1 1 0 0 1 1 1 1 Ham1 family MIB_HERC2 PF06701.11 MSTRG.6290.1_1 - 1.8e-48 162.5 27.4 3.6e-24 84.7 10.6 3.9 4 0 0 4 4 4 2 Mib_herc2 Ank_2 PF12796.5 MSTRG.6290.1_1 - 7.8e-41 138.4 12.2 9.6e-14 51.6 1.0 5.4 2 1 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.6290.1_1 - 1.3e-36 123.9 8.1 3.9e-09 36.5 0.1 6.9 3 1 5 8 8 8 6 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.6290.1_1 - 4e-35 118.6 8.9 1.6e-05 25.0 0.4 9.0 9 0 0 9 9 9 6 Ankyrin repeat Ank_4 PF13637.4 MSTRG.6290.1_1 - 4.8e-30 103.4 8.5 1.1e-06 28.9 0.0 7.5 4 3 3 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.6290.1_1 - 1e-25 86.8 4.1 0.0075 16.6 0.0 9.4 10 0 0 10 10 10 5 Ankyrin repeat zf-C3HC4_3 PF13920.4 MSTRG.6290.1_1 - 5e-11 42.2 46.8 3.1e-07 30.0 10.0 3.7 3 1 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) ZZ PF00569.15 MSTRG.6290.1_1 - 4.3e-10 39.1 9.4 4.3e-10 39.1 9.4 3.3 3 0 0 3 3 3 1 Zinc finger, ZZ type Cnn_1N PF07989.9 MSTRG.6043.2_2 - 0.009 16.0 1.1 0.011 15.7 1.1 1.1 1 0 0 1 1 1 1 Centrosomin N-terminal motif 1 Transthyretin PF00576.19 MSTRG.17269.1_2 - 1.8e-34 118.6 0.0 2.4e-34 118.2 0.0 1.2 1 0 0 1 1 1 1 HIUase/Transthyretin family SAM_1 PF00536.28 MSTRG.25904.1_1 - 1e-10 41.8 0.0 2e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 MSTRG.25904.1_1 - 7.4e-07 29.1 0.0 1.4e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH PF00169.27 MSTRG.25904.1_1 - 0.00035 20.9 0.0 0.00068 20.0 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_3 PF14593.4 MSTRG.25904.1_1 - 0.12 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 PH domain DUF2380 PF09533.8 MSTRG.25904.1_2 - 0.11 11.9 1.8 0.27 10.7 1.8 1.5 1 0 0 1 1 1 0 Predicted lipoprotein of unknown function (DUF2380) SDA1 PF05285.10 MSTRG.16323.1_3 - 0.81 8.9 55.4 1.1 8.4 55.4 1.1 1 0 0 1 1 1 0 SDA1 zf-BED PF02892.13 MSTRG.22247.1_3 - 0.001 18.9 0.1 0.0023 17.8 0.1 1.5 1 0 0 1 1 1 1 BED zinc finger Treslin_N PF15292.4 MSTRG.9791.2_2 - 9.1e-136 454.2 15.8 1.1e-135 453.9 15.8 1.0 1 0 0 1 1 1 1 Treslin N-terminus 7tm_2 PF00002.22 MSTRG.5357.1_2 - 9.1e-21 74.1 8.6 1.7e-20 73.2 8.6 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.19 MSTRG.5357.1_2 - 3.2e-11 43.6 1.7 1.1e-10 41.8 1.7 2.0 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Cpn60_TCP1 PF00118.22 MSTRG.19786.1_2 - 0.0017 16.9 0.0 0.0023 16.5 0.0 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family TMPIT PF07851.11 MSTRG.8685.1_1 - 1.8e-125 418.4 12.2 2e-125 418.2 12.2 1.0 1 0 0 1 1 1 1 TMPIT-like protein DUF2353 PF09789.7 MSTRG.8685.1_1 - 0.00012 21.5 2.8 0.00016 21.0 2.8 1.1 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) Alpha_adaptin_C PF02296.14 MSTRG.8685.1_1 - 0.019 15.0 1.0 0.23 11.5 0.9 2.4 2 1 0 2 2 2 0 Alpha adaptin AP2, C-terminal domain DUF342 PF03961.11 MSTRG.8685.1_1 - 0.51 8.7 3.9 0.66 8.4 3.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Macoilin PF09726.7 MSTRG.8685.1_1 - 1.8 6.9 8.1 0.11 10.9 2.9 1.5 2 0 0 2 2 2 0 Transmembrane protein RhoGEF PF00621.18 MSTRG.27038.1_1 - 1e-35 123.5 2.0 1.8e-35 122.7 2.0 1.4 1 0 0 1 1 1 1 RhoGEF domain Zn_ribbon_17 PF17120.3 MSTRG.21561.1_2 - 1.9e-12 46.5 12.9 6.3e-12 44.8 12.9 2.0 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type WD40 PF00400.30 MSTRG.21561.1_2 - 1e-11 45.0 20.7 0.00011 22.7 0.2 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat zinc_ribbon_16 PF17034.3 MSTRG.21561.1_2 - 3.4e-06 27.2 5.9 3.4e-06 27.2 5.9 2.6 1 1 1 2 2 2 1 Zinc-ribbon like family eIF2A PF08662.9 MSTRG.21561.1_2 - 1.2e-05 25.1 0.1 0.0017 18.1 0.0 2.4 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.5 MSTRG.21561.1_2 - 0.012 15.7 1.1 5.8 7.2 0.1 3.6 1 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Cornichon PF03311.12 MSTRG.8950.1_2 - 1.7e-46 157.4 12.8 2.7e-46 156.7 12.8 1.3 1 0 0 1 1 1 1 Cornichon protein CTP_transf_1 PF01148.18 MSTRG.8950.1_2 - 0.0051 16.5 1.6 0.0066 16.1 1.6 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family Filament PF00038.19 MSTRG.8474.1_1 - 4.6e-91 305.5 46.4 5.8e-91 305.2 46.4 1.1 1 0 0 1 1 1 1 Intermediate filament protein LTD PF00932.17 MSTRG.8474.1_1 - 5.3e-13 49.2 0.1 9.2e-13 48.4 0.1 1.4 1 0 0 1 1 1 1 Lamin Tail Domain PspB PF06667.10 MSTRG.8474.1_1 - 0.23 11.4 6.5 0.032 14.2 1.0 2.4 2 0 0 2 2 2 0 Phage shock protein B BNR PF02012.18 MSTRG.25124.1_3 - 0.026 14.3 0.0 0.051 13.5 0.0 1.5 1 0 0 1 1 1 0 BNR/Asp-box repeat MHC_I PF00129.16 MSTRG.9287.1_3 - 4.6e-18 65.3 0.1 4.8e-18 65.2 0.1 1.0 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 MHC_I_2 PF14586.4 MSTRG.9287.1_3 - 0.099 12.4 0.1 0.11 12.2 0.1 1.0 1 0 0 1 1 1 0 Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2 7tm_1 PF00001.19 MSTRG.10001.2_3 - 2.6e-13 49.7 6.6 3.7e-13 49.2 6.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Far-17a_AIG1 PF04750.12 MSTRG.10001.2_3 - 0.016 14.4 4.3 0.2 10.8 1.9 2.2 2 0 0 2 2 2 0 FAR-17a/AIG1-like protein Porin_3 PF01459.20 MSTRG.9485.1_2 - 6.4e-58 196.2 0.1 8.2e-58 195.9 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic porin Metallophos PF00149.26 MSTRG.26899.1_1 - 1.2e-35 123.7 0.2 1.6e-35 123.3 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TINF2_N PF14973.4 MSTRG.4785.1_2 - 2.8e-47 160.6 0.9 4.9e-47 159.8 0.9 1.4 1 0 0 1 1 1 1 TERF1-interacting nuclear factor 2 N-terminus zf-H2C2_2 PF13465.4 MSTRG.4785.1_2 - 2.1e-38 128.9 100.7 6.9e-08 32.5 0.2 14.6 15 0 0 15 15 15 10 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.4785.1_2 - 2.1e-32 109.6 119.0 2.3e-05 24.5 1.5 14.3 14 0 0 14 14 14 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.4785.1_2 - 4.8e-32 107.7 118.6 0.00049 20.6 3.6 14.6 14 0 0 14 14 14 12 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.4785.1_2 - 1.2e-12 47.7 72.9 0.068 13.4 0.1 12.7 13 0 0 13 13 13 10 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 MSTRG.4785.1_2 - 5.9e-06 26.0 97.6 0.0002 21.1 2.4 14.1 15 1 0 15 15 15 5 C2H2-type zinc finger zf-met PF12874.5 MSTRG.4785.1_2 - 0.038 14.2 76.2 0.1 12.9 0.2 12.2 12 0 0 12 12 12 0 Zinc-finger of C2H2 type zf-C2HE PF16278.3 MSTRG.4785.1_2 - 1.5 9.2 73.1 0.31 11.4 0.7 11.7 7 4 5 12 12 12 0 C2HE / C2H2 / C2HC zinc-binding finger GAGA PF09237.9 MSTRG.4785.1_2 - 4.4 7.1 24.5 7.2 6.4 0.0 7.2 5 3 3 8 8 8 0 GAGA factor CpXC PF14353.4 MSTRG.4785.1_2 - 6 6.8 43.5 0.043 13.7 1.0 7.3 2 1 6 8 8 8 0 CpXC protein Otopetrin PF03189.11 MSTRG.29463.1_3 - 1.7e-17 63.2 0.0 2e-17 63.0 0.0 1.0 1 0 0 1 1 1 1 Otopetrin G-alpha PF00503.18 MSTRG.14189.1_2 - 2.5e-123 411.6 3.4 3.2e-123 411.2 3.4 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 MSTRG.14189.1_2 - 1.4e-16 60.3 0.1 4.2e-12 45.7 0.0 2.6 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.11 MSTRG.14189.1_2 - 0.0013 18.9 1.2 1.9 8.6 0.1 2.7 2 1 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.10 MSTRG.14189.1_2 - 0.002 17.4 3.9 0.085 12.1 0.5 2.5 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region TniB PF05621.9 MSTRG.14189.1_2 - 0.14 11.2 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein S10_plectin PF03501.13 MSTRG.21384.1_1 - 3.3e-34 116.7 0.0 3.8e-34 116.5 0.0 1.0 1 0 0 1 1 1 1 Plectin/S10 domain Kinase-like PF14531.4 MSTRG.21384.1_1 - 0.0047 16.2 0.0 0.0053 16.0 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Runt PF00853.17 MSTRG.12367.1_3 - 2.1e-52 176.0 0.2 3.1e-52 175.4 0.2 1.3 1 0 0 1 1 1 1 Runt domain RunxI PF08504.9 MSTRG.12367.1_3 - 3.8e-37 126.8 5.7 7.8e-37 125.8 5.7 1.6 1 0 0 1 1 1 1 Runx inhibition domain zf-H2C2_2 PF13465.4 MSTRG.21528.3_2 - 5.7e-36 121.2 30.9 3.3e-07 30.3 1.1 7.8 7 1 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.21528.3_2 - 3.6e-21 74.3 54.3 0.00045 20.4 1.3 7.7 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.21528.3_2 - 4.3e-18 64.3 56.5 0.0033 18.0 1.6 8.2 8 0 0 8 8 8 7 C2H2-type zinc finger zf-met PF12874.5 MSTRG.21528.3_2 - 3.6e-11 42.9 37.5 0.0037 17.5 1.3 7.3 7 0 0 7 7 7 5 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.21528.3_2 - 4.7e-10 39.4 25.0 0.21 11.8 0.4 7.2 7 0 0 7 7 7 5 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 MSTRG.21528.3_2 - 1.8e-05 25.2 11.8 0.094 13.3 0.2 4.0 2 1 1 4 4 3 2 zinc-ribbon family zf-Di19 PF05605.10 MSTRG.21528.3_2 - 0.00019 21.5 26.6 0.0023 18.0 3.9 5.1 4 1 0 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.5 MSTRG.21528.3_2 - 0.0084 16.3 23.1 1.1 9.5 3.2 6.3 2 1 2 5 5 5 1 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.4 MSTRG.21528.3_2 - 0.074 12.7 0.0 0.074 12.7 0.0 6.1 6 0 0 6 6 6 0 C2H2-type zinc-finger domain Elf1 PF05129.11 MSTRG.21528.3_2 - 0.17 11.8 18.5 0.63 10.0 1.5 5.4 2 1 4 6 6 6 0 Transcription elongation factor Elf1 like zinc_ribbon_4 PF13717.4 MSTRG.21528.3_2 - 0.25 11.2 20.5 1.6 8.6 0.7 5.9 4 3 0 4 4 4 0 zinc-ribbon domain DUF3268 PF11672.6 MSTRG.21528.3_2 - 2.9 8.1 6.5 2.7 8.2 1.1 3.1 2 1 1 3 3 3 0 zinc-finger-containing domain DUF4713 PF15831.3 MSTRG.21528.3_3 - 0.62 10.4 5.5 1.3 9.4 5.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) Ig_3 PF13927.4 MSTRG.24553.1_1 - 5.4e-20 71.7 0.1 9.3e-11 42.1 0.0 3.5 2 2 1 3 3 3 2 Immunoglobulin domain I-set PF07679.14 MSTRG.24553.1_1 - 8e-19 67.4 0.0 2.4e-11 43.4 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.24553.1_1 - 1.5e-15 57.2 0.4 1.3e-07 31.7 0.0 3.4 4 0 0 4 4 4 2 Immunoglobulin domain TSP_1 PF00090.17 MSTRG.24553.1_1 - 3.2e-14 52.8 34.1 5.9e-05 23.1 3.4 4.5 3 1 0 3 3 3 3 Thrombospondin type 1 domain ig PF00047.23 MSTRG.24553.1_1 - 4.1e-08 33.2 1.0 0.003 17.6 0.0 4.1 3 2 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 MSTRG.24553.1_1 - 1.3e-06 28.4 0.1 0.096 12.7 0.0 3.4 2 2 2 4 4 4 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 MSTRG.24553.1_1 - 1.8e-06 27.8 0.2 0.056 13.4 0.0 3.4 2 1 1 3 3 3 2 CD80-like C2-set immunoglobulin domain PCRF PF03462.16 MSTRG.3964.1_1 - 9.2e-53 178.8 1.1 9.2e-53 178.8 1.1 2.1 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.18 MSTRG.3964.1_1 - 4.8e-39 132.8 5.0 4.8e-39 132.8 5.0 1.8 2 0 0 2 2 2 1 RF-1 domain Moulting_cycle PF04870.14 MSTRG.3964.1_1 - 1.1 8.3 11.7 0.096 11.8 4.3 2.1 2 0 0 2 2 2 0 Moulting cycle AAA_23 PF13476.4 MSTRG.3964.1_1 - 1.1 9.6 11.2 0.66 10.3 3.4 2.2 2 0 0 2 2 2 0 AAA domain Bystin PF05291.9 MSTRG.13965.3_3 - 3e-06 26.6 0.0 4.1e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Bystin Bap31 PF05529.10 MSTRG.26756.1_2 - 4.4e-71 238.5 3.8 6.3e-71 238.0 3.8 1.2 1 0 0 1 1 1 1 B-cell receptor-associated protein 31-like LMF1 PF06762.12 MSTRG.26756.1_2 - 0.00046 19.2 0.3 0.00065 18.7 0.3 1.3 1 0 0 1 1 1 1 Lipase maturation factor DUF4201 PF13870.4 MSTRG.26756.1_2 - 0.006 16.1 3.8 0.0095 15.5 3.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) ATG16 PF08614.9 MSTRG.26756.1_2 - 0.017 15.2 6.6 0.025 14.6 6.6 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) CALCOCO1 PF07888.9 MSTRG.26756.1_2 - 0.13 10.7 7.0 0.17 10.3 7.0 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Atg14 PF10186.7 MSTRG.26756.1_2 - 0.16 10.9 4.2 0.22 10.4 4.2 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Seryl_tRNA_N PF02403.20 MSTRG.26756.1_2 - 0.18 11.9 6.3 0.3 11.2 6.3 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain GAS PF13851.4 MSTRG.26756.1_2 - 0.2 10.9 12.1 0.85 8.8 12.1 1.7 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Filament PF00038.19 MSTRG.26756.1_2 - 0.21 11.0 6.2 0.31 10.5 6.2 1.1 1 0 0 1 1 1 0 Intermediate filament protein Spc7 PF08317.9 MSTRG.26756.1_2 - 0.24 10.1 8.3 0.34 9.6 8.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein PRKG1_interact PF15898.3 MSTRG.26756.1_2 - 0.24 12.2 5.4 0.43 11.4 5.4 1.4 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain MPS2 PF17060.3 MSTRG.26756.1_2 - 0.3 10.2 1.6 0.46 9.6 1.6 1.2 1 0 0 1 1 1 0 Monopolar spindle protein 2 AATF-Che1 PF13339.4 MSTRG.26756.1_2 - 0.33 11.5 4.1 0.57 10.7 4.1 1.3 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor Rootletin PF15035.4 MSTRG.26756.1_2 - 0.33 10.9 7.3 1.7 8.5 1.2 2.1 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion IFP_35_N PF07334.11 MSTRG.26756.1_2 - 0.4 10.6 2.7 0.37 10.8 0.5 1.9 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus APG6 PF04111.10 MSTRG.26756.1_2 - 0.48 9.6 6.7 0.77 9.0 6.7 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 CC2-LZ PF16516.3 MSTRG.26756.1_2 - 0.72 10.1 6.0 0.34 11.1 1.6 2.3 3 0 0 3 3 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator IncA PF04156.12 MSTRG.26756.1_2 - 0.99 9.0 10.2 3.6 7.2 10.2 1.9 1 1 0 1 1 1 0 IncA protein DUF2968 PF11180.6 MSTRG.26756.1_2 - 1.4 8.5 5.5 1.9 8.0 5.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) CENP-F_leu_zip PF10473.7 MSTRG.26756.1_2 - 1.5 8.7 11.2 4.4 7.2 11.0 1.6 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cnn_1N PF07989.9 MSTRG.26756.1_2 - 1.7 8.7 6.9 6.8 6.8 6.9 2.0 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 Phage_GP20 PF06810.9 MSTRG.26756.1_2 - 2.1 8.0 11.4 0.33 10.6 6.8 1.7 1 1 1 2 2 2 0 Phage minor structural protein GP20 DUF3450 PF11932.6 MSTRG.26756.1_2 - 2.3 7.3 6.6 5.2 6.1 6.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) BST2 PF16716.3 MSTRG.26756.1_2 - 2.4 8.7 6.9 13 6.3 0.8 2.3 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 KASH_CCD PF14662.4 MSTRG.26756.1_2 - 3.5 7.3 10.1 6 6.5 10.1 1.3 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH TPR_MLP1_2 PF07926.10 MSTRG.26756.1_2 - 3.8 7.4 12.8 0.45 10.4 3.5 2.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein JIP_LZII PF16471.3 MSTRG.26756.1_2 - 4 7.6 7.5 9.9 6.3 0.6 3.1 3 1 0 3 3 3 0 JNK-interacting protein leucine zipper II Jnk-SapK_ap_N PF09744.7 MSTRG.26756.1_2 - 7.3 6.7 11.1 36 4.4 11.1 1.9 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF972 PF06156.11 MSTRG.26756.1_2 - 7.5 7.1 7.3 31 5.1 1.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF972) SHE3 PF17078.3 MSTRG.26756.1_2 - 8.8 5.8 9.9 29 4.1 9.9 1.7 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 Sec34 PF04136.13 MSTRG.26756.1_2 - 9.3 6.0 7.4 2.5 7.8 1.9 2.1 2 0 0 2 2 2 0 Sec34-like family Oxysterol_BP PF01237.16 MSTRG.20394.4_2 - 9.4e-70 235.1 0.1 1.5e-69 234.5 0.1 1.2 1 0 0 1 1 1 1 Oxysterol-binding protein PH PF00169.27 MSTRG.20394.4_2 - 1.4e-11 44.7 0.0 2.8e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 MSTRG.20394.4_2 - 2e-08 34.2 0.0 4.1e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.4 MSTRG.20394.4_2 - 4.3e-05 23.6 0.0 9.3e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.4 MSTRG.20394.4_2 - 0.042 14.1 0.0 0.09 13.0 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain PH_13 PF16652.3 MSTRG.20394.4_2 - 0.068 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain EGF_CA PF07645.13 MSTRG.1631.1_2 - 8.5e-13 48.2 32.1 5.2e-09 36.0 9.5 6.5 5 3 1 6 6 6 2 Calcium-binding EGF domain DUF3456 PF11938.6 MSTRG.1631.1_2 - 1.4e-09 38.5 3.2 0.00069 20.0 0.0 2.6 1 1 1 2 2 2 2 TLR4 regulator and MIR-interacting MSAP hEGF PF12661.5 MSTRG.1631.1_2 - 0.03 14.9 2.8 0.03 14.9 2.8 7.5 6 2 1 7 7 7 0 Human growth factor-like EGF EGF PF00008.25 MSTRG.1631.1_2 - 0.038 14.2 47.6 0.11 12.7 5.9 6.4 4 1 1 5 5 5 0 EGF-like domain fn3 PF00041.19 MSTRG.29278.1_1 - 0.019 15.2 0.0 0.025 14.8 0.0 1.2 1 0 0 1 1 1 0 Fibronectin type III domain DUF3016 PF11454.6 MSTRG.29278.1_1 - 0.067 12.8 0.0 0.072 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3016) Fungus-induced PF10917.6 MSTRG.24733.1_1 - 0.29 11.3 1.6 0.65 10.2 1.6 1.5 1 0 0 1 1 1 0 Fungus-induced protein SelP_N PF04592.12 MSTRG.24733.1_2 - 8.9 5.5 9.3 0.48 9.6 1.9 2.0 2 0 0 2 2 2 0 Selenoprotein P, N terminal region YchF-GTPase_C PF06071.11 MSTRG.8818.3_2 - 2.2e-40 136.6 0.4 2.2e-40 136.6 0.4 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.21 MSTRG.8818.3_2 - 4.3e-06 26.7 0.1 2.3e-05 24.3 0.0 2.0 1 1 1 2 2 2 1 50S ribosome-binding GTPase TGS PF02824.19 MSTRG.8818.3_2 - 0.00032 20.5 0.0 0.00079 19.3 0.0 1.6 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.21 MSTRG.8818.3_3 - 1.1e-12 48.0 0.0 1.8e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 MSTRG.8818.3_3 - 3e-07 30.0 0.0 4.2e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Ferrous iron transport protein B ArgK PF03308.14 MSTRG.8818.3_3 - 0.008 15.1 0.0 0.012 14.5 0.0 1.2 1 0 0 1 1 1 1 ArgK protein GPHR_N PF12537.6 MSTRG.16241.1_1 - 1.3e-28 98.7 0.3 3.3e-28 97.5 0.1 1.8 2 0 0 2 2 2 1 The Golgi pH Regulator (GPHR) Family N-terminal ABA_GPCR PF12430.6 MSTRG.16241.1_1 - 1.6e-17 63.7 0.1 1.6e-17 63.7 0.1 2.2 2 0 0 2 2 2 1 Abscisic acid G-protein coupled receptor NPCC PF08058.9 MSTRG.16241.1_1 - 0.024 14.6 4.8 2.3 8.2 0.0 2.5 2 0 0 2 2 2 0 Nuclear pore complex component NBP1 PF08537.8 MSTRG.16241.1_1 - 0.034 13.4 0.8 0.049 12.9 0.8 1.1 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 ABA_GPCR PF12430.6 MSTRG.16241.1_3 - 8.3e-14 51.6 2.1 1.6e-13 50.7 2.1 1.4 1 0 0 1 1 1 1 Abscisic acid G-protein coupled receptor EF-hand_7 PF13499.4 MSTRG.19451.2_3 - 7.2e-11 42.3 2.8 7.2e-11 42.3 2.8 3.3 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.19451.2_3 - 1.7e-07 30.5 1.3 0.00012 21.6 0.1 3.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.30 MSTRG.19451.2_3 - 1.7e-07 30.2 2.2 0.0039 16.5 0.2 3.5 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.4 MSTRG.19451.2_3 - 0.0072 15.9 0.5 4.8 6.9 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.19451.2_3 - 0.021 14.2 5.9 0.042 13.3 0.2 3.6 3 0 0 3 3 3 0 EF hand DUF4810 PF16068.3 MSTRG.19451.2_3 - 7.5 7.0 8.4 0.69 10.4 0.2 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4810) Filament PF00038.19 MSTRG.13795.1_2 - 2.7e-93 312.9 34.2 3.1e-93 312.6 34.2 1.0 1 0 0 1 1 1 1 Intermediate filament protein GAS PF13851.4 MSTRG.13795.1_2 - 0.011 15.0 29.5 2.4 7.3 0.1 3.9 3 1 0 3 3 3 0 Growth-arrest specific micro-tubule binding DUF2461 PF09365.8 MSTRG.13795.1_2 - 0.075 12.8 2.2 8.9 6.1 0.1 3.6 2 1 1 4 4 4 0 Conserved hypothetical protein (DUF2461) TACC PF05010.12 MSTRG.13795.1_2 - 0.12 12.0 23.8 0.077 12.6 18.8 2.2 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC) DivIC PF04977.13 MSTRG.13795.1_2 - 0.27 10.9 23.4 0.67 9.6 0.7 4.9 5 1 0 5 5 5 0 Septum formation initiator DUF5082 PF16888.3 MSTRG.13795.1_2 - 0.33 11.2 20.8 0.56 10.4 0.5 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5082) DUF4094 PF13334.4 MSTRG.13795.1_2 - 0.88 9.9 7.6 0.24 11.7 1.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) TMF_DNA_bd PF12329.6 MSTRG.13795.1_2 - 7.3 6.5 28.3 8.3 6.4 3.4 4.7 3 2 1 4 4 4 0 TATA element modulatory factor 1 DNA binding IncA PF04156.12 MSTRG.13795.1_2 - 7.3 6.2 35.8 0.56 9.8 19.1 3.3 1 1 1 3 3 3 0 IncA protein RhoGEF PF00621.18 MSTRG.24774.1_1 - 9.4e-31 107.3 0.6 1.4e-30 106.7 0.6 1.3 1 0 0 1 1 1 1 RhoGEF domain Sec8_exocyst PF04048.12 MSTRG.24774.1_1 - 0.039 13.7 0.0 0.18 11.6 0.0 2.1 1 1 0 1 1 1 0 Sec8 exocyst complex component specific domain Vitellogenin_N PF01347.20 MSTRG.13557.1_1 - 4.1e-165 550.6 0.6 4.1e-165 550.6 0.6 2.1 2 0 0 2 2 2 1 Lipoprotein amino terminal region DUF1943 PF09172.9 MSTRG.13557.1_1 - 7.6e-59 199.4 2.4 8e-59 199.3 0.0 2.3 2 1 1 3 3 3 1 Domain of unknown function (DUF1943) SPX PF03105.17 MSTRG.13557.1_1 - 0.033 14.0 13.4 0.048 13.5 13.4 1.2 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.7 MSTRG.13557.1_1 - 3.3 6.4 23.5 4.8 5.8 23.5 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Ctr PF04145.13 MSTRG.13557.1_3 - 0.48 10.9 3.6 0.75 10.3 3.6 1.3 1 0 0 1 1 1 0 Ctr copper transporter family DUF4834 PF16118.3 MSTRG.13557.1_3 - 3.8 8.4 14.3 7.9 7.4 14.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) PGM_PMM_I PF02878.14 MSTRG.11385.1_1 - 4e-36 123.6 0.0 7.2e-36 122.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.14 MSTRG.11385.1_1 - 1.2e-22 80.3 0.0 2.6e-22 79.2 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.14 MSTRG.11385.1_1 - 4.6e-13 49.2 0.1 1.3e-12 47.8 0.1 1.9 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.18 MSTRG.11385.1_1 - 7.3e-06 25.9 0.0 2.2e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain VWD PF00094.23 MSTRG.11951.7_3 - 9.4e-162 532.8 25.7 1.9e-38 132.1 0.0 5.3 5 0 0 5 5 5 5 von Willebrand factor type D domain C8 PF08742.9 MSTRG.11951.7_3 - 2.1e-78 258.5 34.5 1.1e-23 83.3 1.1 8.8 10 0 0 10 10 10 4 C8 domain TILa PF12714.5 MSTRG.11951.7_3 - 4.5e-56 186.5 102.6 6.4e-15 54.7 11.8 12.9 12 0 0 12 12 12 6 TILa domain TIL PF01826.15 MSTRG.11951.7_3 - 1.4e-51 172.4 136.6 1e-12 48.0 15.3 15.5 16 0 0 16 16 16 6 Trypsin Inhibitor like cysteine rich domain VWC PF00093.16 MSTRG.11951.7_3 - 7.3e-06 26.1 23.8 0.0002 21.5 9.4 14.5 11 5 2 14 14 14 6 von Willebrand factor type C domain Myosin_N PF02736.17 MSTRG.11951.7_3 - 0.022 14.5 1.5 0.21 11.3 0.5 2.5 2 0 0 2 2 2 0 Myosin N-terminal SH3-like domain SRF-TF PF00319.16 MSTRG.6108.1_3 - 1.1e-22 79.1 0.4 2.1e-22 78.2 0.4 1.5 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.6 MSTRG.6108.1_3 - 3.2e-06 26.9 0.1 9.9e-06 25.3 0.1 1.8 1 0 0 1 1 1 1 Holliday junction regulator protein family C-terminal repeat TrbI PF03743.12 MSTRG.6108.1_3 - 0.039 13.7 2.2 0.076 12.7 2.2 1.4 1 0 0 1 1 1 0 Bacterial conjugation TrbI-like protein ABC_membrane PF00664.21 MSTRG.10208.2_2 - 3.3e-34 118.7 1.5 5.4e-34 117.9 1.5 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.25 MSTRG.10208.2_2 - 3.8e-28 98.6 0.0 1e-27 97.2 0.0 1.8 2 0 0 2 2 2 1 ABC transporter AAA_30 PF13604.4 MSTRG.10208.2_2 - 0.00041 20.0 0.2 0.002 17.7 0.2 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 MSTRG.10208.2_2 - 0.0024 18.1 4.8 0.0052 17.0 0.3 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.4 MSTRG.10208.2_2 - 0.0034 17.5 2.9 0.081 13.1 0.7 3.2 2 1 0 2 2 2 1 AAA domain SMC_N PF02463.17 MSTRG.10208.2_2 - 0.0071 15.7 0.1 3.9 6.7 0.0 2.4 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.4 MSTRG.10208.2_2 - 0.0088 15.7 0.0 3.2 7.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RNA_pol_A_CTD PF03118.13 MSTRG.10208.2_2 - 0.041 13.5 0.6 3.7 7.2 0.0 2.3 2 0 0 2 2 2 0 Bacterial RNA polymerase, alpha chain C terminal domain DUF258 PF03193.14 MSTRG.10208.2_2 - 0.05 13.4 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_29 PF13555.4 MSTRG.10208.2_2 - 0.054 13.1 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.12 MSTRG.10208.2_2 - 0.097 12.5 0.2 1.9 8.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) SbcCD_C PF13558.4 MSTRG.10208.2_2 - 0.11 12.6 0.0 0.31 11.2 0.0 1.8 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.4 MSTRG.10208.2_2 - 0.2 11.0 2.0 1 8.8 0.1 2.3 2 0 0 2 2 2 0 AAA domain UPF0193 PF05250.9 MSTRG.10208.2_3 - 0.096 12.3 0.5 0.16 11.6 0.5 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0193) Iso_dh PF00180.18 MSTRG.13713.2_3 - 8.9e-75 251.9 0.1 1.1e-74 251.5 0.1 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase I-set PF07679.14 MSTRG.2659.1_1 - 2.6e-91 299.7 1.6 1.8e-17 63.0 0.0 8.4 8 0 0 8 8 8 7 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.2659.1_1 - 5.9e-48 161.3 5.5 1.3e-09 38.3 0.0 8.5 8 0 0 8 8 8 7 Immunoglobulin domain fn3 PF00041.19 MSTRG.2659.1_1 - 4.5e-45 151.8 12.2 4.7e-10 39.5 0.0 6.0 6 0 0 6 6 6 4 Fibronectin type III domain Ig_2 PF13895.4 MSTRG.2659.1_1 - 3.1e-21 75.4 9.9 5.2e-06 26.6 0.0 7.5 7 0 0 7 7 7 4 Immunoglobulin domain ig PF00047.23 MSTRG.2659.1_1 - 7.9e-19 67.5 2.0 0.0028 17.7 0.1 6.7 7 0 0 7 7 7 4 Immunoglobulin domain V-set PF07686.15 MSTRG.2659.1_1 - 5e-15 55.5 7.2 0.018 15.1 0.1 9.0 8 3 2 10 10 10 4 Immunoglobulin V-set domain C2-set_2 PF08205.10 MSTRG.2659.1_1 - 1.2e-05 25.1 0.1 1.1 9.3 0.0 4.8 4 0 0 4 4 4 1 CD80-like C2-set immunoglobulin domain Pur_ac_phosph_N PF16656.3 MSTRG.2659.1_1 - 0.00051 20.4 14.7 0.076 13.5 0.0 5.7 7 1 0 7 7 7 2 Purple acid Phosphatase, N-terminal domain Spectrin PF00435.19 MSTRG.21156.4_1 - 2e-70 233.8 22.6 4.3e-25 88.1 4.4 4.3 4 0 0 4 4 4 4 Spectrin repeat CH PF00307.29 MSTRG.21156.4_1 - 3.6e-54 181.5 1.8 9e-27 93.3 0.0 2.9 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.8 MSTRG.21156.4_1 - 1.5e-26 92.2 0.0 4.3e-26 90.7 0.0 1.9 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_1 PF00036.30 MSTRG.21156.4_1 - 7.9e-10 37.4 0.1 0.00064 19.0 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.4 MSTRG.21156.4_1 - 4.3e-07 29.2 0.5 0.0031 17.2 0.0 3.9 3 0 0 3 3 3 2 EF-hand domain CAMSAP_CH PF11971.6 MSTRG.21156.4_1 - 5.6e-07 29.2 0.0 2.4e-05 24.0 0.0 2.6 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_7 PF13499.4 MSTRG.21156.4_1 - 3e-06 27.5 0.7 1.5e-05 25.2 0.1 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.4 MSTRG.21156.4_1 - 0.006 16.2 0.2 0.25 11.0 0.0 3.3 3 0 0 3 3 3 1 EF-hand domain pair CH_2 PF06294.9 MSTRG.21156.4_1 - 0.013 15.5 0.1 0.71 9.9 0.1 2.9 2 0 0 2 2 2 0 CH-like domain in sperm protein BTB_2 PF02214.20 MSTRG.623.1_1 - 1.5e-14 54.0 0.0 3.1e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain CEP76-C2 PF15627.4 MSTRG.623.1_1 - 0.16 11.4 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 CEP76 C2 domain Peptidase_S24 PF00717.21 MSTRG.23189.1_3 - 1.7e-10 40.6 0.0 3.8e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.7 MSTRG.23189.1_3 - 9.2e-07 28.6 0.0 0.00092 18.9 0.0 2.5 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 DnaJ PF00226.29 MSTRG.29809.1_3 - 4.3e-23 81.1 0.4 6.4e-23 80.5 0.4 1.3 1 0 0 1 1 1 1 DnaJ domain Thioredoxin PF00085.18 MSTRG.29809.1_3 - 1.4e-06 28.0 0.0 2.2e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.4 MSTRG.29809.1_3 - 0.023 15.0 0.1 0.057 13.7 0.0 1.6 2 0 0 2 2 2 0 Thioredoxin-like domain RVT_1 PF00078.25 MSTRG.8261.1_3 - 5.3e-14 52.1 0.0 8.5e-14 51.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) NGF PF00243.16 MSTRG.20273.1_1 - 1.1e-35 122.1 0.7 1.6e-35 121.6 0.7 1.2 1 0 0 1 1 1 1 Nerve growth factor family FAM91_C PF14648.4 MSTRG.20273.1_3 - 0.041 12.6 0.2 0.053 12.2 0.2 1.1 1 0 0 1 1 1 0 FAM91 C-terminus Aldo_ket_red PF00248.19 MSTRG.1613.1_1 - 1.8e-53 181.5 0.0 2.9e-53 180.8 0.0 1.3 1 0 0 1 1 1 1 Aldo/keto reductase family UBA PF00627.29 MSTRG.21730.1_3 - 2.2e-27 94.4 3.2 7e-14 51.3 0.2 2.5 2 0 0 2 2 2 2 UBA/TS-N domain XPC-binding PF09280.9 MSTRG.21730.1_3 - 4.6e-24 83.8 18.3 8.3e-24 83.0 18.3 1.4 1 0 0 1 1 1 1 XPC-binding domain ubiquitin PF00240.21 MSTRG.21730.1_3 - 2.6e-21 75.0 2.4 4.5e-21 74.2 2.4 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 MSTRG.21730.1_3 - 1.7e-07 30.9 4.1 2.5e-07 30.3 4.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.4 MSTRG.21730.1_3 - 2.5e-05 24.2 0.1 4.4e-05 23.4 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.8 MSTRG.21730.1_3 - 0.0034 17.0 0.0 0.093 12.4 0.0 2.3 2 0 0 2 2 2 1 Fungal ubiquitin-associated domain DUF2407 PF10302.7 MSTRG.21730.1_3 - 0.0049 17.3 0.0 0.0094 16.4 0.0 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain DUF1296 PF06972.9 MSTRG.21730.1_3 - 0.031 14.3 0.0 1.7 8.7 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1296) Ubiquitin_2 PF14560.4 MSTRG.21730.1_3 - 0.069 13.5 0.5 0.14 12.5 0.5 1.6 1 1 0 1 1 1 0 Ubiquitin-like domain DNA_pol_A_exo1 PF01612.18 MSTRG.8850.2_3 - 7.8e-16 58.2 0.0 1.2e-15 57.5 0.0 1.2 1 0 0 1 1 1 1 3'-5' exonuclease Ribosomal_S14 PF00253.19 MSTRG.8850.2_3 - 0.0061 16.2 0.1 0.11 12.2 0.0 2.4 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e RRXRR PF14239.4 MSTRG.8850.2_3 - 0.088 12.5 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 RRXRR protein TPR_12 PF13424.4 MSTRG.16347.9_3 - 0.01 16.0 10.6 0.062 13.5 2.9 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF3496 PF12001.6 MSTRG.16347.9_3 - 0.12 12.6 0.6 0.2 11.9 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3496) AAA_16 PF13191.4 MSTRG.16347.9_3 - 0.16 12.2 2.2 0.22 11.7 1.4 1.6 1 1 0 1 1 1 0 AAA ATPase domain Ribosomal_L29 PF00831.21 MSTRG.26895.1_1 - 4.8e-21 74.3 2.6 4.8e-21 74.3 2.6 2.4 2 0 0 2 2 2 1 Ribosomal L29 protein Snapin_Pallidin PF14712.4 MSTRG.26895.1_1 - 2.7 8.4 9.2 0.22 11.9 2.9 2.0 1 1 2 3 3 3 0 Snapin/Pallidin Ras PF00071.20 MSTRG.24221.1_1 - 5.4e-56 188.5 0.1 7.8e-56 188.0 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.24221.1_1 - 6.6e-36 123.0 0.1 1.1e-35 122.3 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.24221.1_1 - 3e-13 49.4 0.0 4.7e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 MSTRG.24221.1_1 - 0.00032 20.0 0.0 0.00044 19.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 MSTRG.24221.1_1 - 0.0049 16.3 0.0 0.0075 15.7 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 MSTRG.24221.1_1 - 0.0073 16.3 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 MSTRG.24221.1_1 - 0.079 12.7 0.1 1.3 8.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 ANAPC5 PF12862.5 MSTRG.2963.2_3 - 4.3e-28 97.1 14.2 5.6e-27 93.5 1.9 4.1 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 5 TPR_12 PF13424.4 MSTRG.2963.2_3 - 0.0023 18.1 9.5 0.5 10.6 0.5 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.2963.2_3 - 0.84 9.7 6.9 16 5.7 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat PH PF00169.27 MSTRG.24914.1_2 - 4.1e-06 27.1 0.0 4.8e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 PH domain Dendrin PF15498.4 MSTRG.24914.1_2 - 0.16 10.6 1.5 0.21 10.1 1.5 1.0 1 0 0 1 1 1 0 Nephrin and CD2AP-binding protein, Dendrin Defensin_beta_2 PF13841.4 MSTRG.941.2_1 - 0.12 12.7 1.3 0.29 11.5 1.3 1.6 1 0 0 1 1 1 0 Beta defensin I-set PF07679.14 MSTRG.215.5_1 - 1.4e-10 40.9 0.0 1.7e-09 37.5 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.215.5_1 - 0.00014 22.3 0.0 0.00026 21.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 MSTRG.215.5_1 - 0.00037 20.5 0.0 0.00075 19.5 0.0 1.6 2 0 0 2 2 2 1 Immunoglobulin domain DUF1163 PF06651.9 MSTRG.215.5_1 - 0.1 12.6 0.1 1.7 8.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1163) CzcE PF16986.3 MSTRG.215.5_1 - 0.12 12.6 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 Heavy-metal resistance protein CzcE Ig_2 PF13895.4 MSTRG.215.5_1 - 0.13 12.5 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain DUF3614 PF12267.6 MSTRG.15293.1_2 - 0.049 14.0 0.1 0.059 13.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3614) BET PF17035.3 MSTRG.27701.6_2 - 1.2e-28 99.0 0.2 2.4e-28 98.0 0.2 1.6 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation BRD4_CDT PF17105.3 MSTRG.27701.6_2 - 2.7e-24 84.3 11.9 2.7e-24 84.3 11.9 4.0 4 0 0 4 4 4 1 C-terminal domain of bromodomain protein 4 DUF3915 PF13054.4 MSTRG.27888.1_1 - 2.8 7.8 5.3 5.3 6.9 5.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) 7tm_1 PF00001.19 MSTRG.27888.1_2 - 3.4e-38 131.3 14.1 4.9e-38 130.8 14.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 MSTRG.27888.1_2 - 6e-06 25.7 12.3 8.4e-06 25.2 12.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 MSTRG.27888.1_2 - 0.0021 17.7 17.1 0.04 13.5 17.1 3.2 1 1 0 1 1 1 1 Olfactory receptor DUF3915 PF13054.4 MSTRG.27888.1_3 - 0.015 15.1 0.9 0.031 14.1 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Cbl_N PF02262.14 MSTRG.9358.1_3 - 1.5e-54 183.2 1.5 2.6e-54 182.4 1.5 1.4 1 0 0 1 1 1 1 CBL proto-oncogene N-terminal domain 1 Cbl_N3 PF02762.12 MSTRG.9358.1_3 - 6.4e-44 147.6 0.0 1.1e-43 146.8 0.0 1.4 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, SH2-like domain Cbl_N2 PF02761.12 MSTRG.9358.1_3 - 1.8e-40 137.4 0.9 3.3e-40 136.5 0.9 1.5 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, EF hand-like domain Prok-RING_4 PF14447.4 MSTRG.9358.1_3 - 7.7e-12 44.8 9.6 1.9e-11 43.5 9.6 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.4 MSTRG.9358.1_3 - 9.2e-10 38.1 9.0 9.2e-10 38.1 9.0 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 MSTRG.9358.1_3 - 1.9e-07 30.7 8.3 1.9e-07 30.7 8.3 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.9358.1_3 - 1.4e-06 28.4 8.4 1.4e-06 28.4 8.4 2.7 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.4 MSTRG.9358.1_3 - 0.0011 18.7 8.7 0.0011 18.7 8.7 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) UBA PF00627.29 MSTRG.9358.1_3 - 0.007 16.1 0.0 0.03 14.1 0.0 2.1 2 0 0 2 2 2 1 UBA/TS-N domain zf-RING_5 PF14634.4 MSTRG.9358.1_3 - 6 6.8 18.3 0.13 12.2 10.6 2.2 2 0 0 2 2 2 0 zinc-RING finger domain AF-4 PF05110.11 MSTRG.9546.2_1 - 2.6e-220 734.6 134.8 3e-220 734.4 134.8 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein Med16 PF11635.6 MSTRG.24377.1_3 - 7.4e-43 146.4 0.0 9.4e-43 146.1 0.0 1.0 1 0 0 1 1 1 1 Mediator complex subunit 16 WD40 PF00400.30 MSTRG.24377.1_3 - 0.0017 19.0 7.4 0.0018 18.9 2.4 3.3 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.24377.1_3 - 0.0019 18.3 0.5 0.23 11.7 0.1 2.8 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain EF-hand_7 PF13499.4 MSTRG.24636.1_3 - 7.8e-26 90.2 3.0 2.1e-17 63.2 0.0 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.30 MSTRG.24636.1_3 - 1e-22 77.8 5.2 1.9e-06 26.9 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.4 MSTRG.24636.1_3 - 1.8e-20 71.3 3.5 1.3e-06 27.5 0.1 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 MSTRG.24636.1_3 - 1.3e-19 68.3 2.3 1.6e-05 24.4 0.1 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 MSTRG.24636.1_3 - 8.6e-17 60.5 1.6 2.3e-06 27.1 0.1 3.6 2 1 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 MSTRG.24636.1_3 - 9.5e-05 22.6 0.2 0.024 14.8 0.1 3.2 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 MSTRG.24636.1_3 - 0.0018 18.1 0.4 1.7 8.5 0.0 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand zf-C2HC PF01530.16 MSTRG.18070.2_3 - 0.16 12.1 0.3 0.29 11.3 0.3 1.3 1 0 0 1 1 1 0 Zinc finger, C2HC type TMEM214 PF10151.7 MSTRG.19962.5_1 - 2.2e-92 310.5 0.5 2.6e-92 310.3 0.5 1.0 1 0 0 1 1 1 1 TMEM214, C-terminal, caspase 4 activator DAG_kinase_N PF14513.4 MSTRG.19962.5_1 - 0.12 12.4 3.2 0.18 11.8 3.2 1.2 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus AIG1 PF04548.14 MSTRG.27882.2_2 - 6.8e-77 257.4 0.0 3e-41 141.0 0.0 2.2 2 0 0 2 2 2 2 AIG1 family MMR_HSR1 PF01926.21 MSTRG.27882.2_2 - 0.00076 19.4 0.0 0.0035 17.3 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.25 MSTRG.27882.2_2 - 0.0021 18.5 0.0 1.3 9.4 0.0 2.8 2 0 0 2 2 2 2 ABC transporter AAA_16 PF13191.4 MSTRG.27882.2_2 - 0.005 17.1 0.0 1.1 9.5 0.0 2.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.4 MSTRG.27882.2_2 - 0.0084 16.3 0.0 3.7 7.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.14 MSTRG.27882.2_2 - 0.044 13.5 0.0 2.7 7.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Dynamin_N PF00350.21 MSTRG.27882.2_2 - 0.18 11.7 0.7 2 8.3 0.0 2.6 3 0 0 3 3 3 0 Dynamin family zf-H2C2_2 PF13465.4 MSTRG.16169.4_3 - 1.1e-53 177.3 57.1 1e-07 31.9 0.3 8.7 9 0 0 9 9 8 8 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.16169.4_3 - 3.9e-31 105.6 70.3 2.9e-06 27.3 1.9 9.0 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.16169.4_3 - 7.6e-23 79.1 72.3 0.00026 21.4 1.7 9.6 10 0 0 10 10 9 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.16169.4_3 - 5.9e-13 48.3 51.4 5.5e-06 26.1 0.8 8.8 8 0 0 8 8 8 6 C2H2-type zinc finger zf-Di19 PF05605.10 MSTRG.16169.4_3 - 5.7e-06 26.4 36.4 0.042 14.0 1.6 6.3 4 2 2 7 7 7 4 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.6 MSTRG.16169.4_3 - 8.3e-05 22.7 30.4 0.057 13.6 0.1 7.2 8 0 0 8 8 8 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.16169.4_3 - 0.00094 19.4 72.7 0.0036 17.5 1.3 9.3 10 0 0 10 10 8 5 Zinc-finger of C2H2 type ADK_lid PF05191.12 MSTRG.16169.4_3 - 0.0062 16.4 18.3 5.2 7.0 4.0 5.9 4 2 0 4 4 4 1 Adenylate kinase, active site lid LIM PF00412.20 MSTRG.16169.4_3 - 0.0067 16.5 43.5 0.066 13.3 1.7 8.0 3 1 6 9 9 9 3 LIM domain BolA PF01722.16 MSTRG.16169.4_3 - 0.0088 16.2 8.7 8.1 6.7 0.1 4.5 2 2 1 3 3 3 1 BolA-like protein Nudix_N_2 PF14803.4 MSTRG.16169.4_3 - 0.47 10.3 32.3 0.53 10.1 1.3 8.1 6 2 1 7 7 7 0 Nudix N-terminal zf-C2HE PF16278.3 MSTRG.16169.4_3 - 1.3 9.5 42.5 0.46 10.8 2.7 8.8 1 1 7 8 8 8 0 C2HE / C2H2 / C2HC zinc-binding finger zinc_ribbon_15 PF17032.3 MSTRG.16169.4_3 - 1.8 9.2 38.6 0.84 10.3 0.9 5.6 5 1 2 7 7 5 0 zinc-ribbon family DUF3268 PF11672.6 MSTRG.16169.4_3 - 3 8.1 19.0 1.9 8.7 2.3 3.9 2 2 2 5 5 5 0 zinc-finger-containing domain zf-ribbon_3 PF13248.4 MSTRG.16169.4_3 - 3.6 7.0 28.7 5.6 6.4 0.1 8.4 9 0 0 9 9 9 0 zinc-ribbon domain NARP1 PF12569.6 MSTRG.19207.1_1 - 9.2e-218 724.1 23.8 1.2e-217 723.8 23.8 1.1 1 0 0 1 1 1 1 NMDA receptor-regulated protein 1 TPR_14 PF13428.4 MSTRG.19207.1_1 - 2.8e-07 30.6 7.0 0.2 12.4 0.0 6.3 5 1 2 7 7 6 2 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.19207.1_1 - 1.1e-06 28.2 10.5 0.67 10.1 0.0 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.19207.1_1 - 8.5e-05 22.9 5.3 0.017 15.5 0.3 4.1 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.19207.1_1 - 0.00063 19.3 11.0 0.42 10.4 0.0 6.4 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.19207.1_1 - 0.0041 17.6 2.4 12 6.5 0.0 4.8 5 1 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.19207.1_1 - 0.017 15.2 10.8 0.017 15.2 1.5 3.4 2 1 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.4 MSTRG.19207.1_1 - 0.027 14.6 6.9 13 6.2 0.2 5.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_9 PF13371.4 MSTRG.19207.1_1 - 0.063 13.3 0.3 3.3 7.8 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_21 PF09976.7 MSTRG.19207.1_1 - 0.071 12.7 0.1 0.071 12.7 0.1 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat-like domain TPR_17 PF13431.4 MSTRG.19207.1_1 - 0.1 12.9 3.0 15 6.1 0.0 4.4 6 0 0 6 6 5 0 Tetratricopeptide repeat PPR PF01535.18 MSTRG.19207.1_1 - 0.24 11.6 3.9 6.5 7.1 0.0 3.7 4 0 0 4 4 3 0 PPR repeat I-set PF07679.14 MSTRG.7162.1_2 - 1.6e-78 258.7 10.5 6.8e-16 58.0 0.0 6.6 7 0 0 7 7 7 5 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.7162.1_2 - 3.5e-64 213.3 7.1 8e-13 48.7 0.1 6.1 7 0 0 7 7 6 5 Immunoglobulin domain ig PF00047.23 MSTRG.7162.1_2 - 2.7e-46 155.5 1.3 5.3e-10 39.2 0.2 5.4 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.7162.1_2 - 1.7e-42 143.5 1.0 1.3e-08 34.9 0.1 5.4 5 0 0 5 5 5 5 Immunoglobulin domain fn3 PF00041.19 MSTRG.7162.1_2 - 8.3e-29 99.6 1.0 3.1e-13 49.7 0.1 2.8 2 0 0 2 2 2 2 Fibronectin type III domain V-set PF07686.15 MSTRG.7162.1_2 - 3.6e-17 62.4 8.4 0.018 15.1 0.0 7.8 6 3 1 7 7 7 5 Immunoglobulin V-set domain Ig_5 PF16681.3 MSTRG.7162.1_2 - 1.6e-12 47.5 0.1 0.056 13.7 0.0 5.7 5 1 0 5 5 5 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 MSTRG.7162.1_2 - 1.6e-07 31.1 0.6 4 7.4 0.0 5.3 5 0 0 5 5 5 2 Izumo-like Immunoglobulin domain C2-set_2 PF08205.10 MSTRG.7162.1_2 - 1.7e-06 27.9 0.1 0.54 10.2 0.0 4.1 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 MSTRG.7162.1_2 - 6.7e-06 26.4 3.1 0.39 11.1 0.2 5.0 5 0 0 5 5 5 1 Immunoglobulin C1-set domain Ig_4 PF16680.3 MSTRG.7162.1_2 - 1.5e-05 25.1 3.1 1.4 9.2 0.0 6.2 5 2 0 5 5 5 1 T-cell surface glycoprotein CD3 delta chain Pur_ac_phosph_N PF16656.3 MSTRG.7162.1_2 - 6.1e-05 23.4 3.4 0.1 13.1 0.2 3.7 3 2 0 3 3 2 2 Purple acid Phosphatase, N-terminal domain Adeno_E3_CR1 PF02440.13 MSTRG.7162.1_2 - 0.00078 19.1 1.1 4.9 6.9 0.0 4.4 4 0 0 4 4 4 1 Adenovirus E3 region protein CR1 Arylsulfotrans PF05935.9 MSTRG.7162.1_2 - 0.0019 16.9 0.0 0.013 14.1 0.0 2.1 1 1 0 2 2 2 1 Arylsulfotransferase (ASST) V-set_CD47 PF08204.9 MSTRG.7162.1_2 - 0.0095 15.8 6.5 5.2 6.9 0.0 5.0 4 2 1 5 5 5 1 CD47 immunoglobulin-like domain C2-set PF05790.13 MSTRG.7162.1_2 - 0.25 11.4 1.1 8.1 6.6 0.0 3.5 5 0 0 5 5 5 0 Immunoglobulin C2-set domain TF_AP-2 PF03299.12 MSTRG.4841.1_3 - 3.7e-09 36.7 0.1 1.8e-08 34.5 0.0 1.9 1 1 1 2 2 2 1 Transcription factor AP-2 SAS-6_N PF16531.3 MSTRG.6848.1_3 - 0.021 15.3 0.0 0.032 14.7 0.0 1.3 1 0 0 1 1 1 0 Centriolar protein SAS N-terminal MutS_V PF00488.19 MSTRG.21895.2_1 - 2.2e-83 278.8 0.2 3.8e-83 278.1 0.2 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.16 MSTRG.21895.2_1 - 2.4e-36 125.6 1.0 6.5e-36 124.2 1.0 1.7 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.16 MSTRG.21895.2_1 - 5e-19 68.3 0.2 1.5e-18 66.8 0.0 1.9 2 0 0 2 2 2 1 MutS family domain IV MutS_II PF05188.15 MSTRG.21895.2_1 - 5.9e-18 65.3 0.1 1.8e-17 63.8 0.1 1.8 1 0 0 1 1 1 1 MutS domain II MutS_I PF01624.18 MSTRG.21895.2_1 - 6.1e-18 65.0 0.2 2.9e-17 62.8 0.1 2.0 2 0 0 2 2 2 1 MutS domain I T3SS_needle_reg PF09025.8 MSTRG.21895.2_1 - 0.012 15.4 0.0 1.2 8.9 0.0 2.5 2 0 0 2 2 2 0 YopR, type III needle-polymerisation regulator AAA_27 PF13514.4 MSTRG.21895.2_1 - 0.044 13.2 0.1 0.13 11.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain DUF2208 PF09973.7 MSTRG.16015.1_3 - 0.022 14.2 2.4 0.027 14.0 2.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) tRNA-synt_2_TM PF16995.3 MSTRG.16015.1_3 - 0.064 12.8 3.3 0.089 12.3 3.3 1.1 1 0 0 1 1 1 0 Transmembrane region of lysyl-tRNA synthetase SPT_ssu-like PF11779.6 MSTRG.16015.1_3 - 0.93 9.0 9.6 1.6 8.2 9.6 1.4 1 0 0 1 1 1 0 Small subunit of serine palmitoyltransferase-like WD40 PF00400.30 MSTRG.17229.3_3 - 4.4e-10 39.9 0.4 0.003 18.2 0.0 3.8 3 0 0 3 3 3 2 WD domain, G-beta repeat TPR_19 PF14559.4 MSTRG.17229.3_3 - 1.7e-05 25.1 0.0 3.7e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.17229.3_3 - 3.3e-05 23.5 5.5 0.12 12.4 0.1 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.17229.3_3 - 0.00048 19.7 8.1 0.0037 16.9 1.6 3.6 3 1 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.17229.3_3 - 0.0051 16.8 3.2 0.011 15.8 3.1 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.4 MSTRG.17229.3_3 - 0.012 15.2 0.7 2.2 7.9 0.3 2.3 2 0 0 2 2 2 0 TPR repeat TPR_6 PF13174.4 MSTRG.17229.3_3 - 0.012 16.1 0.4 0.057 13.9 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.17229.3_3 - 0.023 15.3 0.8 0.058 14.1 0.1 2.0 3 0 0 3 3 1 0 Tetratricopeptide repeat TPR_9 PF13371.4 MSTRG.17229.3_3 - 0.024 14.6 0.0 0.048 13.7 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.17229.3_3 - 0.042 14.1 2.2 0.43 11.0 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.17229.3_3 - 0.065 13.8 0.5 1.4 9.5 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.17229.3_3 - 0.1 12.7 0.3 20 5.6 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Tub PF01167.16 MSTRG.21817.1_3 - 1.4e-84 283.0 0.1 2.5e-84 282.2 0.0 1.5 2 0 0 2 2 2 1 Tub family Tub_N PF16322.3 MSTRG.21817.1_3 - 3e-33 115.8 13.9 1.3e-19 71.2 4.6 2.4 1 1 1 2 2 2 2 Tubby N-terminal DUF3527 PF12043.6 MSTRG.21817.1_3 - 0.26 10.7 1.9 0.87 9.0 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3527) Ank_2 PF12796.5 MSTRG.23832.1_2 - 1.6e-15 57.3 0.0 2.3e-08 34.4 0.0 1.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.23832.1_2 - 1.7e-13 50.6 0.0 1.5e-09 38.1 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.23832.1_2 - 7e-11 41.9 0.1 2.3e-08 34.0 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.4 MSTRG.23832.1_2 - 2.2e-09 37.3 0.0 4.6e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.23832.1_2 - 5.3e-08 32.4 0.0 4.3e-06 26.5 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.5 MSTRG.23832.1_3 - 1.7e-09 38.0 0.4 5.2e-07 30.0 0.2 2.7 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.23832.1_3 - 2.1e-08 34.1 1.1 9.3e-07 28.9 0.1 2.7 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.23832.1_3 - 1.6e-07 31.3 0.3 3.6e-06 27.0 0.1 3.3 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.4 MSTRG.23832.1_3 - 5.6e-07 29.9 0.1 8.5e-05 22.9 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeats (many copies) PH PF00169.27 MSTRG.23832.1_3 - 2e-05 24.9 1.5 3.7e-05 24.0 1.5 1.5 1 0 0 1 1 1 1 PH domain Ank_3 PF13606.4 MSTRG.23832.1_3 - 0.00032 20.8 0.2 0.14 12.6 0.0 3.8 4 0 0 4 4 4 1 Ankyrin repeat PH_11 PF15413.4 MSTRG.23832.1_3 - 0.00049 20.4 2.1 0.0014 18.9 2.1 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain Pkinase PF00069.23 MSTRG.11785.3_3 - 1.8e-60 204.4 0.0 2.7e-60 203.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.11785.3_3 - 1.1e-36 126.3 0.0 1.8e-36 125.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PB1 PF00564.22 MSTRG.11785.3_3 - 4.8e-13 48.7 0.7 1e-12 47.6 0.7 1.6 1 0 0 1 1 1 1 PB1 domain Kinase-like PF14531.4 MSTRG.11785.3_3 - 7.6e-06 25.3 0.0 0.0019 17.4 0.0 2.3 2 0 0 2 2 2 2 Kinase-like IPT PF01745.14 MSTRG.11785.3_3 - 0.0016 17.8 0.0 0.0026 17.0 0.0 1.2 1 0 0 1 1 1 1 Isopentenyl transferase Kdo PF06293.12 MSTRG.11785.3_3 - 0.074 12.3 0.0 0.17 11.1 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 MSTRG.11785.3_3 - 0.1 12.1 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 PX PF00787.22 MSTRG.26571.1_2 - 1.1e-16 60.7 0.2 2.1e-16 59.8 0.2 1.5 1 0 0 1 1 1 1 PX domain LRR_4 PF12799.5 MSTRG.26571.1_2 - 2.9e-14 52.7 35.5 1.5e-05 25.1 1.6 5.0 3 1 4 7 7 7 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 MSTRG.26571.1_2 - 3.4e-14 52.2 13.0 0.00053 19.6 0.0 3.6 3 0 0 3 3 3 3 Leucine rich repeat LRR_9 PF14580.4 MSTRG.26571.1_2 - 4.5e-08 32.7 0.6 8.3e-08 31.8 0.6 1.4 1 0 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.4 MSTRG.26571.1_2 - 4.6e-05 23.0 16.5 0.39 10.8 0.1 6.4 6 0 0 6 6 6 3 Leucine Rich repeat LRR_1 PF00560.31 MSTRG.26571.1_2 - 0.012 15.8 19.3 15 6.4 0.3 7.5 6 1 1 7 7 7 0 Leucine Rich Repeat NUDIX PF00293.26 MSTRG.2138.1_2 - 1.8e-08 34.4 0.0 0.016 15.1 0.0 3.2 3 0 0 3 3 3 3 NUDIX domain tRNA-synt_1g PF09334.9 MSTRG.26996.2_3 - 2.1e-148 494.2 0.0 2.7e-148 493.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) WHEP-TRS PF00458.18 MSTRG.26996.2_3 - 2e-16 59.7 4.6 2e-16 59.7 4.6 1.9 2 0 0 2 2 2 1 WHEP-TRS domain tRNA-synt_1 PF00133.20 MSTRG.26996.2_3 - 1.3e-08 33.5 0.5 0.0001 20.6 0.0 2.4 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) GST_C_3 PF14497.4 MSTRG.26996.2_3 - 0.00016 21.6 0.0 0.00093 19.2 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 MSTRG.26996.2_3 - 0.0064 16.6 0.0 0.017 15.2 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.18 MSTRG.26996.2_3 - 0.019 15.1 0.0 0.046 13.9 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 MSTRG.26996.2_3 - 0.093 12.9 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain zinc-ribbons_6 PF07191.10 MSTRG.26996.2_3 - 1.6 8.7 8.2 4.6 7.2 4.8 2.4 1 1 1 2 2 2 0 zinc-ribbons HypA PF01155.17 MSTRG.26996.2_3 - 1.9 8.4 5.9 2.4 8.1 0.3 2.7 2 1 1 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Ig_3 PF13927.4 MSTRG.6741.1_1 - 2.7e-23 82.3 0.1 2.5e-06 27.9 0.1 4.4 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.14 MSTRG.6741.1_1 - 9.7e-17 60.7 0.0 0.00039 20.3 0.0 5.3 4 2 0 4 4 4 4 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.6741.1_1 - 1.2e-14 54.2 0.2 4.1e-09 36.5 0.1 3.6 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 MSTRG.6741.1_1 - 2e-11 43.8 0.0 0.017 15.2 0.0 5.2 5 1 0 5 5 5 4 Immunoglobulin domain V-set PF07686.15 MSTRG.6741.1_1 - 5.7e-10 39.2 0.0 3.6e-05 23.7 0.0 4.0 4 0 0 4 4 4 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 MSTRG.6741.1_1 - 3.4e-05 23.7 1.6 0.023 14.6 0.1 3.5 3 1 0 3 3 3 1 CD80-like C2-set immunoglobulin domain BiPBP_C PF06832.10 MSTRG.6741.1_1 - 0.00029 20.7 0.0 0.15 12.0 0.0 3.6 3 1 1 4 4 4 1 Penicillin-Binding Protein C-terminus Family ERAP1_C PF11838.6 MSTRG.28535.1_3 - 0.0012 18.3 0.0 0.0016 17.9 0.0 1.2 1 0 0 1 1 1 1 ERAP1-like C-terminal domain NO_synthase PF02898.13 MSTRG.16777.3_3 - 1.8e-192 639.1 0.0 2.6e-192 638.6 0.0 1.2 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain FAD_binding_1 PF00667.18 MSTRG.16777.3_3 - 2e-80 269.4 0.1 4.1e-80 268.4 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.23 MSTRG.16777.3_3 - 2.6e-49 167.0 0.1 6.6e-49 165.7 0.1 1.8 1 1 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.19 MSTRG.16777.3_3 - 4.3e-20 72.2 0.0 1e-19 71.1 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Med20 PF08612.9 MSTRG.13966.1_2 - 4.8e-47 160.1 0.0 5.6e-47 159.8 0.0 1.0 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex Filamin PF00630.17 MSTRG.904.2_1 - 2e-15 57.3 0.0 4.3e-15 56.3 0.0 1.6 1 0 0 1 1 1 1 Filamin/ABP280 repeat zf-B_box PF00643.22 MSTRG.904.2_1 - 1.4e-10 41.0 3.9 1.4e-10 41.0 3.9 3.1 2 1 1 3 3 2 1 B-box zinc finger zf-RING_UBOX PF13445.4 MSTRG.904.2_1 - 2.9e-10 39.8 6.5 2.9e-10 39.8 6.5 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 MSTRG.904.2_1 - 6.6e-08 32.1 9.6 6.6e-08 32.1 9.6 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 MSTRG.904.2_1 - 6.7e-08 32.1 10.2 6.7e-08 32.1 10.2 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) NHL PF01436.19 MSTRG.904.2_1 - 8.2e-08 31.8 0.9 2e-06 27.4 0.1 3.1 3 0 0 3 3 2 1 NHL repeat zf-C3HC4_3 PF13920.4 MSTRG.904.2_1 - 1.1e-07 31.5 7.1 1.1e-07 31.5 7.1 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 MSTRG.904.2_1 - 3.2e-07 30.1 8.0 3.2e-07 30.1 8.0 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 MSTRG.904.2_1 - 7.1e-07 29.3 9.2 7.1e-07 29.3 9.2 2.1 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.4 MSTRG.904.2_1 - 7.8e-06 25.8 17.8 2.5e-05 24.2 12.0 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.4 MSTRG.904.2_1 - 4.1e-05 23.2 8.8 4.1e-05 23.2 8.8 2.4 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 YtkA PF13115.4 MSTRG.904.2_1 - 0.00025 21.5 0.0 0.00055 20.3 0.0 1.5 1 0 0 1 1 1 1 YtkA-like zf-ANAPC11 PF12861.5 MSTRG.904.2_1 - 0.0032 17.4 1.1 0.007 16.3 1.1 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger DUF5128 PF17170.2 MSTRG.904.2_1 - 0.012 14.6 0.0 0.017 14.1 0.0 1.2 1 0 0 1 1 1 0 6-bladed beta-propeller Invasin_D3 PF09134.8 MSTRG.904.2_1 - 0.013 15.1 0.1 0.032 13.8 0.1 1.6 1 0 0 1 1 1 0 Invasin, domain 3 Lipoprotein_20 PF13942.4 MSTRG.904.2_1 - 0.033 14.0 0.1 0.077 12.8 0.1 1.6 1 0 0 1 1 1 0 YfhG lipoprotein Big_1 PF02369.14 MSTRG.904.2_1 - 0.041 13.8 0.8 0.12 12.3 0.8 1.7 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) Baculo_PEP_C PF04513.10 MSTRG.904.2_1 - 0.14 12.1 0.5 0.29 11.0 0.5 1.5 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus zf-RING_11 PF17123.3 MSTRG.904.2_1 - 0.18 11.4 6.0 0.094 12.3 3.3 2.0 1 1 0 1 1 1 0 RING-like zinc finger Spectrin PF00435.19 MSTRG.904.2_1 - 0.2 12.1 4.9 0.083 13.3 1.1 2.1 2 0 0 2 2 2 0 Spectrin repeat MAP7 PF05672.9 MSTRG.15099.2_2 - 5.7e-29 100.8 61.4 5.1e-19 68.4 34.4 4.5 3 2 1 4 4 4 3 MAP7 (E-MAP-115) family LRR_8 PF13855.4 MSTRG.23328.1_3 - 9.2e-67 220.6 112.1 9.3e-14 50.8 2.4 12.0 7 3 6 14 14 14 12 Leucine rich repeat LRR_4 PF12799.5 MSTRG.23328.1_3 - 7.7e-27 92.7 70.7 7.8e-05 22.8 1.3 11.9 6 2 5 12 12 12 9 Leucine Rich repeats (2 copies) TIR PF01582.18 MSTRG.23328.1_3 - 6.7e-26 91.0 0.0 1e-25 90.4 0.0 1.3 1 0 0 1 1 1 1 TIR domain LRR_9 PF14580.4 MSTRG.23328.1_3 - 1.3e-15 57.2 29.4 4.5e-06 26.1 2.5 6.9 2 2 4 7 7 7 5 Leucine-rich repeat TIR_2 PF13676.4 MSTRG.23328.1_3 - 6.3e-12 45.6 0.0 1.2e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 TIR domain LRR_1 PF00560.31 MSTRG.23328.1_3 - 0.0058 16.8 57.6 3.2 8.5 0.2 15.3 15 2 1 16 16 16 4 Leucine Rich Repeat Codanin-1_C PF15296.4 MSTRG.19857.1_2 - 8.2e-36 122.7 0.0 1.5e-35 121.8 0.0 1.5 1 0 0 1 1 1 1 Codanin-1 C-terminus ChaC PF04752.10 MSTRG.17728.1_2 - 3.1e-63 212.9 0.0 3.8e-63 212.6 0.0 1.1 1 0 0 1 1 1 1 ChaC-like protein GGACT PF06094.10 MSTRG.17728.1_2 - 0.00035 21.0 0.2 0.00052 20.5 0.2 1.2 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like DUF4799 PF16056.3 MSTRG.26827.1_1 - 0.015 14.4 0.0 0.021 13.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4799) EGF_CA PF07645.13 MSTRG.8020.1_3 - 4e-41 138.8 102.1 1.1e-10 41.4 9.1 8.6 9 1 0 9 9 9 6 Calcium-binding EGF domain cEGF PF12662.5 MSTRG.8020.1_3 - 9e-34 114.9 45.5 1e-09 38.0 0.3 7.8 7 0 0 7 7 7 6 Complement Clr-like EGF-like FXa_inhibition PF14670.4 MSTRG.8020.1_3 - 2.9e-10 40.1 37.6 7e-06 26.1 7.6 8.0 7 1 1 8 8 8 4 Coagulation Factor Xa inhibitory site EGF_3 PF12947.5 MSTRG.8020.1_3 - 1.2e-05 25.3 16.2 8.1e-05 22.6 8.7 8.0 8 1 1 9 9 9 5 EGF domain EGF PF00008.25 MSTRG.8020.1_3 - 0.00023 21.2 23.0 0.00032 20.8 6.6 8.6 9 0 0 9 9 9 4 EGF-like domain hEGF PF12661.5 MSTRG.8020.1_3 - 0.019 15.5 5.2 0.019 15.5 5.2 10.7 10 2 0 10 10 10 0 Human growth factor-like EGF Copper-fist PF00649.16 MSTRG.5764.2_2 - 0.086 12.2 6.6 0.5 9.8 6.6 2.4 1 0 0 1 1 1 0 Copper fist DNA binding domain MH2 PF03166.12 MSTRG.5764.2_3 - 2.3e-78 262.5 0.0 3.5e-78 261.9 0.0 1.3 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.14 MSTRG.5764.2_3 - 7.4e-40 135.2 0.2 1.6e-39 134.2 0.2 1.6 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.7 MSTRG.5764.2_3 - 0.055 13.1 0.0 0.094 12.4 0.0 1.3 1 0 0 1 1 1 0 Interferon-regulatory factor 3 UPF1_Zn_bind PF09416.8 MSTRG.10581.1_2 - 7.8e-75 249.8 6.8 2e-74 248.5 6.6 1.9 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.4 MSTRG.10581.1_2 - 1.5e-61 207.3 0.0 6.2e-61 205.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.4 MSTRG.10581.1_2 - 5.3e-48 163.9 2.4 1.5e-26 93.5 0.4 2.3 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.4 MSTRG.10581.1_2 - 1.1e-12 47.9 0.0 4.9e-12 45.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.4 MSTRG.10581.1_2 - 3.5e-10 40.2 0.0 9.8e-10 38.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain ResIII PF04851.13 MSTRG.10581.1_2 - 3.3e-05 23.8 0.0 6.5e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.7 MSTRG.10581.1_2 - 0.00055 19.1 0.0 0.0045 16.2 0.0 2.3 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.12 MSTRG.10581.1_2 - 0.0016 18.2 0.0 0.0032 17.2 0.0 1.5 1 0 0 1 1 1 1 Helicase SRP54 PF00448.20 MSTRG.10581.1_2 - 0.012 15.1 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ATPase PF06745.11 MSTRG.10581.1_2 - 0.031 13.5 0.0 0.24 10.6 0.0 2.0 2 0 0 2 2 2 0 KaiC UvrD_C_2 PF13538.4 MSTRG.10581.1_2 - 0.049 13.3 0.1 0.68 9.7 0.0 2.4 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain SepSecS PF05889.11 MSTRG.24544.1_3 - 2e-163 543.5 0.0 2.4e-163 543.3 0.0 1.1 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Beta_elim_lyase PF01212.19 MSTRG.24544.1_3 - 0.0013 18.0 0.0 0.002 17.4 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase CcmH PF03918.12 MSTRG.1996.6_1 - 0.056 12.6 0.2 0.1 11.7 0.2 1.4 1 0 0 1 1 1 0 Cytochrome C biogenesis protein HABP4_PAI-RBP1 PF04774.13 MSTRG.1996.6_3 - 1.7e-18 67.4 1.7 1.7e-18 67.4 1.7 2.4 2 0 0 2 2 2 1 Hyaluronan / mRNA binding family IHABP4_N PF16174.3 MSTRG.1996.6_3 - 1.4e-14 54.9 11.4 1.4e-14 54.9 11.4 1.8 1 1 0 1 1 1 1 Intracellular hyaluronan-binding protein 4 N-terminal CCDC106 PF15794.3 MSTRG.1996.6_3 - 0.049 13.2 5.6 0.27 10.8 0.1 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 7tm_1 PF00001.19 MSTRG.4867.2_2 - 7.1e-30 104.0 17.6 1.4e-29 103.1 17.6 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.4 MSTRG.4867.2_2 - 5.3e-23 80.4 1.2 6.8e-09 35.2 0.0 4.9 3 2 3 6 6 6 5 Leucine rich repeat LRR_5 PF13306.4 MSTRG.4867.2_2 - 7.3e-16 58.2 0.0 6.6e-09 35.7 0.0 2.4 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 MSTRG.4867.2_2 - 0.025 14.9 0.6 12 6.4 0.0 4.3 3 2 3 7 7 7 0 Leucine Rich repeats (2 copies) Laminin_G_2 PF02210.22 MSTRG.4867.2_3 - 3.7e-146 479.8 11.8 2.4e-27 95.9 0.0 6.2 6 0 0 6 6 6 6 Laminin G domain Laminin_G_1 PF00054.21 MSTRG.4867.2_3 - 1.1e-102 339.4 0.5 6.1e-23 81.3 0.0 6.4 6 0 0 6 6 6 6 Laminin G domain Laminin_G_3 PF13385.4 MSTRG.4867.2_3 - 3.1e-19 69.5 1.7 0.0053 16.8 0.0 6.4 6 0 0 6 6 6 6 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.25 MSTRG.4867.2_3 - 3.8e-11 42.9 33.5 3.1e-05 24.1 6.9 4.4 3 0 0 3 3 3 3 EGF-like domain Syndecan PF01034.18 MSTRG.4867.2_3 - 7.1e-07 28.9 0.0 1.4e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Syndecan domain WW PF00397.24 MSTRG.17814.3_3 - 2.3e-09 36.9 0.1 4.2e-09 36.1 0.1 1.5 1 0 0 1 1 1 1 WW domain FAM181 PF15238.4 MSTRG.17814.3_3 - 0.21 11.2 16.8 0.045 13.4 9.8 2.2 1 1 1 2 2 2 0 FAM181 NopRA1 PF16201.3 MSTRG.22450.2_1 - 3.8e-56 189.7 1.6 8.1e-56 188.6 0.2 2.2 3 0 0 3 3 3 1 Nucleolar pre-ribosomal-associated protein 1 Ipi1_N PF12333.6 MSTRG.22450.2_1 - 1.4 9.5 4.9 56 4.4 0.1 4.1 4 0 0 4 4 4 0 Rix1 complex component involved in 60S ribosome maturation zf-NF-X1 PF01422.15 MSTRG.8175.2_2 - 0.02 14.8 16.7 0.02 14.8 16.7 7.1 8 0 0 8 8 8 0 NF-X1 type zinc finger DUF4407 PF14362.4 MSTRG.8175.2_2 - 0.023 13.9 0.1 0.024 13.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Crystall PF00030.17 MSTRG.11599.1_3 - 2.3e-57 191.0 9.2 6.8e-29 99.8 2.2 2.0 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 MSTRG.11599.1_3 - 1e-06 28.5 1.6 0.042 13.6 0.0 2.7 2 1 1 3 3 3 2 Peptidase inhibitor family I36 Crystall_3 PF08964.8 MSTRG.11599.1_3 - 0.039 14.0 5.4 0.08 13.0 0.8 2.7 2 2 0 2 2 2 0 Beta/Gamma crystallin Myticin-prepro PF10690.7 MSTRG.13606.1_3 - 0.038 14.1 1.0 0.068 13.3 1.0 1.3 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel SET PF00856.26 MSTRG.5034.1_3 - 5.4e-08 33.3 0.3 2.3e-06 28.0 0.3 2.4 1 1 0 1 1 1 1 SET domain Ribosomal_S6 PF01250.15 MSTRG.16462.1_2 - 0.094 12.9 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S6 CDO_I PF05995.10 MSTRG.1952.1_1 - 4e-66 221.4 0.2 5.2e-66 221.0 0.2 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.10 MSTRG.1952.1_1 - 0.00052 19.4 0.2 0.0011 18.3 0.2 1.6 1 1 0 1 1 1 1 PCO_ADO DASH_Dad4 PF08650.8 MSTRG.1952.1_1 - 0.1 12.5 0.3 0.25 11.2 0.3 1.6 1 0 0 1 1 1 0 DASH complex subunit Dad4 Laminin_G_2 PF02210.22 MSTRG.9075.1_3 - 9.8e-71 236.1 1.1 1.8e-19 70.5 0.0 5.2 5 0 0 5 5 5 5 Laminin G domain Laminin_G_1 PF00054.21 MSTRG.9075.1_3 - 1.9e-54 183.2 0.9 6.8e-17 61.8 0.0 6.1 5 1 0 5 5 5 5 Laminin G domain Laminin_G_3 PF13385.4 MSTRG.9075.1_3 - 7.8e-14 52.0 0.0 0.0016 18.4 0.0 4.3 4 0 0 4 4 4 3 Concanavalin A-like lectin/glucanases superfamily DUF1080 PF06439.9 MSTRG.9075.1_3 - 0.12 12.3 0.0 5.3 7.0 0.0 2.9 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1080) Laminin_II PF06009.10 MSTRG.9075.1_3 - 0.13 12.1 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 Laminin Domain II Spo7_2_N PF15407.4 MSTRG.9075.1_3 - 0.14 11.7 0.7 2.1 8.0 0.0 3.0 4 0 0 4 4 4 0 Sporulation protein family 7 Adaptin_N PF01602.18 MSTRG.4239.1_3 - 5e-139 464.1 0.4 6.1e-139 463.8 0.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.18 MSTRG.4239.1_3 - 4.1e-23 81.7 0.0 7.5e-23 80.8 0.0 1.5 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.5 MSTRG.4239.1_3 - 1.5e-09 38.0 0.3 7.6e-05 22.6 0.1 2.6 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Calx-beta PF03160.12 MSTRG.2752.1_2 - 5e-24 84.2 0.4 5e-24 84.2 0.4 1.6 2 0 0 2 2 2 1 Calx-beta domain DUF3667 PF12412.6 MSTRG.2752.1_2 - 0.17 11.3 0.0 0.26 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3667) MHC_I PF00129.16 MSTRG.19712.5_2 - 3.6e-35 121.0 3.3 4.9e-35 120.6 3.3 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 MSTRG.19712.5_2 - 1.3e-09 38.2 0.0 2.9e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.3 MSTRG.19712.5_2 - 0.00012 21.5 0.3 0.0002 20.7 0.3 1.3 1 0 0 1 1 1 1 MHC-I family domain TMEM154 PF15102.4 MSTRG.19712.5_2 - 0.00045 20.0 0.0 0.00088 19.1 0.0 1.4 1 0 0 1 1 1 1 TMEM154 protein family SecG PF03840.12 MSTRG.19712.5_2 - 0.049 13.6 0.0 0.094 12.7 0.0 1.4 1 0 0 1 1 1 0 Preprotein translocase SecG subunit Ank_2 PF12796.5 MSTRG.10948.4_2 - 1.5e-24 86.2 5.4 7.6e-09 35.9 0.2 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) KN_motif PF12075.6 MSTRG.10948.4_2 - 1.6e-22 78.8 0.8 2.9e-22 78.0 0.8 1.4 1 0 0 1 1 1 1 KN motif Ank_5 PF13857.4 MSTRG.10948.4_2 - 2.6e-21 75.2 3.6 3.1e-12 46.4 0.1 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.10948.4_2 - 5e-18 63.2 3.9 3.7e-05 23.7 0.0 4.9 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.4 MSTRG.10948.4_2 - 1.9e-17 63.2 5.6 3.1e-08 33.9 0.1 4.5 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.10948.4_2 - 4.3e-16 58.4 10.1 0.00032 20.9 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat K-box PF01486.15 MSTRG.10948.4_2 - 2.1 8.5 5.1 0.82 9.8 1.0 2.2 2 0 0 2 2 2 0 K-box region Metallophos PF00149.26 MSTRG.19431.1_1 - 1.4e-38 133.4 0.1 1.9e-38 132.9 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.3 MSTRG.19431.1_1 - 1.2e-22 79.9 1.6 2.7e-22 78.8 1.6 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Acatn PF13000.5 MSTRG.2860.2_2 - 7.7e-15 54.2 15.4 2.9e-13 49.0 6.5 3.2 2 1 0 2 2 2 2 Acetyl-coenzyme A transporter 1 MFS_1 PF07690.14 MSTRG.2860.2_2 - 2.4e-11 43.0 43.1 1e-09 37.7 33.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.18 MSTRG.2860.2_2 - 0.0011 17.2 2.2 0.0017 16.6 2.2 1.2 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family zf-H2C2_2 PF13465.4 MSTRG.15479.1_1 - 2.1e-11 43.6 9.0 3.8e-07 30.1 3.0 6.5 6 0 0 6 6 6 2 Zinc-finger double domain zf-H2C2_5 PF13909.4 MSTRG.15479.1_1 - 1.6e-07 30.8 2.6 0.00011 21.7 0.1 5.1 5 0 0 5 5 5 3 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 MSTRG.15479.1_1 - 0.0028 17.9 48.6 0.17 12.3 0.3 6.6 6 0 0 6 6 6 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.15479.1_1 - 0.75 10.7 46.5 1.5 9.7 2.3 6.7 6 0 0 6 6 6 0 C2H2-type zinc finger PHF5 PF03660.12 MSTRG.15479.1_1 - 4.3 7.5 12.4 0.16 12.1 2.9 2.5 2 0 0 2 2 2 0 PHF5-like protein EMP70 PF02990.14 MSTRG.14714.1_2 - 1.9e-157 524.9 21.4 2.5e-157 524.5 21.4 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 BPS PF08947.8 MSTRG.13477.1_1 - 2.8e-27 94.1 1.3 5.5e-27 93.2 1.3 1.5 1 0 0 1 1 1 1 BPS (Between PH and SH2) SH2 PF00017.22 MSTRG.13477.1_1 - 5.7e-15 55.0 0.0 1.1e-14 54.1 0.0 1.5 1 0 0 1 1 1 1 SH2 domain RA PF00788.21 MSTRG.13477.1_1 - 6.4e-12 45.8 0.1 1.6e-11 44.5 0.1 1.7 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain PH PF00169.27 MSTRG.13477.1_1 - 3.9e-11 43.3 0.1 8.2e-11 42.2 0.1 1.6 1 0 0 1 1 1 1 PH domain PH_9 PF15410.4 MSTRG.13477.1_1 - 0.17 12.2 0.0 0.41 10.9 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain PRIMA1 PF16101.3 MSTRG.13477.1_3 - 0.67 9.9 3.6 2.9 7.8 3.6 2.1 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 LRR_8 PF13855.4 MSTRG.1393.1_1 - 3.2e-17 61.9 17.8 1.6e-06 27.6 1.8 4.3 2 2 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 MSTRG.1393.1_1 - 5.2e-07 29.7 20.4 0.002 18.3 6.4 4.4 1 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 MSTRG.1393.1_1 - 1.7e-06 27.5 13.4 0.14 12.6 0.0 5.7 5 0 0 5 5 5 3 Leucine Rich Repeat LRR_6 PF13516.4 MSTRG.1393.1_1 - 0.00021 21.0 8.6 3.9 7.7 0.2 4.8 4 0 0 4 4 4 2 Leucine Rich repeat LRRNT PF01462.16 MSTRG.1393.1_1 - 0.0003 20.2 2.7 0.0003 20.2 2.7 3.0 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_5 PF13306.4 MSTRG.1393.1_1 - 0.0013 18.5 0.4 0.062 13.1 0.0 2.3 1 1 0 2 2 2 1 Leucine rich repeats (6 copies) LRR_9 PF14580.4 MSTRG.1393.1_1 - 0.0016 17.8 3.3 0.014 14.7 0.7 2.2 1 1 1 2 2 2 1 Leucine-rich repeat TPR_1 PF00515.26 MSTRG.11579.1_1 - 9.1e-33 110.6 11.7 2.6e-06 26.9 0.0 8.2 8 0 0 8 8 8 6 Tetratricopeptide repeat JmjC PF02373.20 MSTRG.11579.1_1 - 8.8e-30 103.4 1.1 8.8e-30 103.4 1.1 2.2 2 0 0 2 2 2 1 JmjC domain, hydroxylase TPR_2 PF07719.15 MSTRG.11579.1_1 - 9.9e-19 65.8 11.9 0.0031 17.4 0.1 8.4 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.11579.1_1 - 1.7e-16 58.9 11.1 0.055 13.6 0.9 7.7 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.11579.1_1 - 6.9e-14 52.1 0.3 0.0003 21.3 0.1 5.3 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.11579.1_1 - 8.9e-13 48.2 3.9 0.018 15.1 0.0 5.5 3 2 3 6 6 6 6 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.11579.1_1 - 1.5e-12 46.8 5.9 0.004 17.3 0.0 5.7 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.11579.1_1 - 2.5e-10 39.7 4.0 0.12 11.9 0.0 6.5 3 2 4 7 7 7 3 TPR repeat TPR_9 PF13371.4 MSTRG.11579.1_1 - 7e-10 38.8 0.1 0.00037 20.5 0.2 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.11579.1_1 - 1.2e-08 34.9 3.4 0.51 11.2 0.1 6.4 4 2 3 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.11579.1_1 - 1e-07 32.2 3.6 0.68 10.4 0.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.11579.1_1 - 1.8e-06 27.4 2.6 3.1 7.9 0.0 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.11579.1_1 - 0.014 15.9 7.4 13 6.5 0.2 6.3 7 0 0 7 7 7 0 Tetratricopeptide repeat RPN7 PF10602.7 MSTRG.11579.1_1 - 0.079 12.5 1.4 0.76 9.3 0.0 2.8 3 0 0 3 3 3 0 26S proteasome subunit RPN7 ANAPC3 PF12895.5 MSTRG.11579.1_1 - 0.41 10.8 6.9 1.8 8.7 0.0 3.7 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 HECT PF00632.23 MSTRG.17714.1_3 - 2.2e-79 267.0 0.4 2.2e-79 267.0 0.4 2.3 3 0 0 3 3 3 1 HECT-domain (ubiquitin-transferase) Filamin PF00630.17 MSTRG.17714.1_3 - 1.9e-09 38.2 0.2 1.6e-08 35.2 0.0 2.4 2 1 0 2 2 2 1 Filamin/ABP280 repeat PLU-1 PF08429.9 MSTRG.17714.1_3 - 0.019 14.0 1.1 0.1 11.6 0.1 2.1 2 0 0 2 2 2 0 PLU-1-like protein SAM_1 PF00536.28 MSTRG.17714.1_3 - 0.03 14.6 1.9 0.45 10.9 0.1 2.4 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Elf-1_N PF12310.6 MSTRG.12053.3_2 - 1.8e-05 25.0 0.0 2.8e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Transcription factor protein N terminal Ets PF00178.20 MSTRG.12053.3_3 - 1.4e-34 118.2 0.5 2.6e-34 117.4 0.5 1.4 1 0 0 1 1 1 1 Ets-domain DRMBL PF07522.12 MSTRG.24225.3_2 - 4.9e-07 29.9 0.6 1.2e-06 28.6 0.1 1.8 2 0 0 2 2 2 1 DNA repair metallo-beta-lactamase DRMBL PF07522.12 MSTRG.24225.3_3 - 0.0027 17.8 0.6 0.012 15.7 0.0 2.1 2 0 0 2 2 2 1 DNA repair metallo-beta-lactamase zf-Tim10_DDP PF02953.13 MSTRG.27266.1_3 - 1.5e-20 72.4 0.5 2.6e-20 71.7 0.5 1.4 1 0 0 1 1 1 1 Tim10/DDP family zinc finger IL8 PF00048.18 MSTRG.11366.3_1 - 4e-13 49.2 0.6 6.6e-13 48.5 0.6 1.4 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like NPR3 PF03666.11 MSTRG.5255.1_3 - 2.2e-38 132.1 4.1 9.4e-38 130.1 4.1 1.7 1 1 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 MMR_HSR1 PF01926.21 MSTRG.15103.1_1 - 1.2e-14 54.2 0.0 4.8e-12 45.8 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.16 MSTRG.15103.1_1 - 3.1e-05 23.4 0.1 0.00011 21.6 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.14 MSTRG.15103.1_1 - 0.00074 19.3 0.0 0.0021 17.9 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 MSTRG.15103.1_1 - 0.015 14.7 0.2 0.72 9.2 0.0 3.2 2 1 0 4 4 4 0 Elongation factor Tu GTP binding domain Arf PF00025.19 MSTRG.15103.1_1 - 0.023 14.0 0.4 0.76 9.1 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family NGP1NT PF08153.10 MSTRG.15103.1_3 - 2.3e-45 153.7 0.4 4.1e-45 153.0 0.4 1.3 1 0 0 1 1 1 1 NGP1NT (NUC091) domain Surp PF01805.18 MSTRG.1671.1_1 - 5.2e-18 64.7 0.1 1.5e-17 63.2 0.1 1.9 1 0 0 1 1 1 1 Surp module RRM_1 PF00076.20 MSTRG.1671.1_1 - 1.3e-15 56.8 0.0 3.4e-15 55.5 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) cwf21 PF08312.10 MSTRG.1671.1_1 - 4.6e-10 39.4 2.2 4.6e-10 39.4 2.2 2.6 2 0 0 2 2 2 1 cwf21 domain CTK3 PF12243.6 MSTRG.1671.1_1 - 0.00078 19.3 0.1 0.002 18.0 0.1 1.6 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTD_bind PF04818.11 MSTRG.1671.1_1 - 0.0021 18.7 0.4 0.0086 16.7 0.4 2.2 1 0 0 1 1 1 1 RNA polymerase II-binding domain. SET_assoc PF11767.6 MSTRG.1671.1_1 - 0.0077 15.7 0.1 0.018 14.5 0.1 1.6 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated DUF2408 PF10303.7 MSTRG.1671.1_1 - 0.011 16.2 0.1 0.011 16.2 0.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2408) CRF PF00473.15 MSTRG.26334.1_3 - 0.018 15.0 0.0 0.064 13.3 0.0 1.8 2 0 0 2 2 2 0 Corticotropin-releasing factor family Clathrin PF00637.18 MSTRG.13320.6_3 - 2.5e-27 95.4 6.1 4e-27 94.7 0.3 2.9 3 0 0 3 3 3 1 Region in Clathrin and VPS Vps39_2 PF10367.7 MSTRG.13320.6_3 - 2.7e-05 24.4 0.5 9.7e-05 22.6 0.5 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.7 MSTRG.13320.6_3 - 0.00086 19.5 4.6 0.027 14.6 0.0 3.4 3 1 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 TPR_7 PF13176.4 MSTRG.13320.6_3 - 0.0029 17.4 2.5 0.25 11.3 1.1 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.13320.6_3 - 0.021 14.8 3.2 3.6 7.8 0.2 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.13320.6_3 - 0.062 13.5 4.7 0.14 12.3 0.2 3.7 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.13320.6_3 - 0.32 10.8 2.1 1.7 8.5 0.5 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.13320.6_3 - 0.39 11.3 2.4 52 4.6 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Zf_RING PF16744.3 MSTRG.13320.6_3 - 0.43 10.6 2.1 1.5 8.9 0.8 2.4 2 0 0 2 2 2 0 KIAA1045 RING finger zf-rbx1 PF12678.5 MSTRG.13320.6_3 - 0.57 10.4 4.3 0.8 9.9 2.8 2.1 2 0 0 2 2 1 0 RING-H2 zinc finger domain zf-RING_2 PF13639.4 MSTRG.13320.6_3 - 1.3 9.2 9.8 0.26 11.4 5.1 2.4 2 0 0 2 2 2 0 Ring finger domain zf-C3H2C3 PF17122.3 MSTRG.13320.6_3 - 1.4 8.9 5.5 0.18 11.8 0.5 2.1 2 0 0 2 2 2 0 Zinc-finger zf-RING_11 PF17123.3 MSTRG.13320.6_3 - 2.6 7.7 8.0 0.2 11.3 2.5 2.1 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_5 PF14634.4 MSTRG.13320.6_3 - 3.5 7.5 7.1 4.9 7.1 5.1 2.4 2 1 0 2 2 2 0 zinc-RING finger domain CENP-F_leu_zip PF10473.7 MSTRG.3844.1_3 - 0.014 15.2 3.0 0.014 15.2 3.0 1.6 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 EST1 PF10374.7 MSTRG.3844.1_3 - 0.056 14.0 0.2 0.16 12.5 0.0 1.8 1 1 1 2 2 2 0 Telomerase activating protein Est1 RAMP4 PF06624.10 MSTRG.1033.2_3 - 4.4e-26 90.6 0.2 7.9e-26 89.8 0.2 1.4 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 DUF1206 PF06724.9 MSTRG.1033.2_3 - 0.019 14.9 0.1 0.031 14.2 0.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1206) DUF1241 PF06840.9 MSTRG.8959.2_3 - 2.3e-54 183.0 6.4 3.3e-54 182.5 6.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) FH2 PF02181.21 MSTRG.8959.2_3 - 0.00077 18.5 1.8 0.0012 18.0 1.8 1.3 1 0 0 1 1 1 1 Formin Homology 2 Domain CENP-L PF13092.4 MSTRG.8959.2_3 - 0.011 15.8 0.5 0.017 15.2 0.5 1.1 1 0 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 Focal_AT PF03623.11 MSTRG.8959.2_3 - 0.056 13.2 0.1 0.096 12.5 0.1 1.3 1 0 0 1 1 1 0 Focal adhesion targeting region Med11 PF10280.7 MSTRG.8959.2_3 - 0.071 13.4 0.3 0.15 12.4 0.3 1.5 1 0 0 1 1 1 0 Mediator complex protein Syntaxin_2 PF14523.4 MSTRG.8959.2_3 - 0.4 11.0 4.6 0.92 9.8 4.6 1.6 1 1 0 1 1 1 0 Syntaxin-like protein fn3 PF00041.19 MSTRG.23469.2_1 - 1.8e-76 252.4 4.1 1.5e-16 60.4 0.0 6.4 6 0 0 6 6 6 5 Fibronectin type III domain I-set PF07679.14 MSTRG.23469.2_1 - 1.7e-68 226.6 5.8 5.4e-18 64.7 0.0 7.6 7 0 0 7 7 7 7 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.23469.2_1 - 5.1e-41 139.0 8.2 2.9e-10 40.5 0.0 7.9 8 0 0 8 8 8 6 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.23469.2_1 - 8.5e-28 96.4 1.6 6.1e-06 26.4 0.0 6.5 7 0 0 7 7 6 5 Immunoglobulin domain ig PF00047.23 MSTRG.23469.2_1 - 4.6e-17 61.8 11.6 0.00031 20.7 0.0 7.6 9 0 0 9 9 7 5 Immunoglobulin domain V-set PF07686.15 MSTRG.23469.2_1 - 5.4e-16 58.6 7.9 0.022 14.8 0.1 8.9 7 3 0 7 7 7 5 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.3 MSTRG.23469.2_1 - 4.6e-08 33.4 12.1 0.38 11.2 0.0 6.9 6 1 0 6 6 5 2 Purple acid Phosphatase, N-terminal domain Tissue_fac PF01108.15 MSTRG.23469.2_1 - 2.6e-05 23.8 1.4 0.59 9.8 0.0 5.0 5 0 0 5 5 5 2 Tissue factor HmuY PF14064.4 MSTRG.23469.2_1 - 0.0016 18.5 0.0 0.0045 17.1 0.0 1.8 1 0 0 1 1 1 1 HmuY protein fn3_2 PF16893.3 MSTRG.23469.2_1 - 0.0043 17.0 0.0 0.57 10.2 0.0 4.3 4 2 0 4 4 4 1 Fibronectin type III domain C2-set_2 PF08205.10 MSTRG.23469.2_1 - 0.036 14.0 8.7 0.91 9.5 0.0 4.6 5 0 0 5 5 4 0 CD80-like C2-set immunoglobulin domain Adeno_E3_CR1 PF02440.13 MSTRG.23469.2_1 - 0.044 13.4 0.5 16 5.2 0.0 3.7 4 0 0 4 4 4 0 Adenovirus E3 region protein CR1 PepSY_2 PF13670.4 MSTRG.23469.2_1 - 0.17 11.8 1.4 5.4 7.0 0.2 3.1 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain MFS_5 PF05631.12 MSTRG.11715.1_3 - 0.077 11.8 0.0 0.1 11.4 0.0 1.1 1 0 0 1 1 1 0 Sugar-tranasporters, 12 TM DUF758 PF05527.9 MSTRG.17452.1_2 - 1.6e-71 239.9 5.0 1.9e-71 239.6 5.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF758) DAO PF01266.22 MSTRG.8941.1_2 - 7e-44 150.7 0.0 8.4e-44 150.4 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.4 MSTRG.8941.1_2 - 0.0011 19.0 0.0 0.0031 17.6 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.17 MSTRG.8941.1_2 - 0.0013 17.9 0.3 0.03 13.4 0.1 2.1 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.15 MSTRG.8941.1_2 - 0.0084 15.2 0.0 0.013 14.6 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.12 MSTRG.8941.1_2 - 0.022 13.9 0.0 0.31 10.1 0.0 2.1 1 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.10 MSTRG.8941.1_2 - 0.054 12.4 0.0 0.1 11.5 0.0 1.4 2 0 0 2 2 2 0 Lycopene cyclase protein Mqo PF06039.13 MSTRG.8941.1_2 - 0.22 9.9 0.0 0.3 9.5 0.0 1.1 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) UPF0556 PF10572.7 MSTRG.8437.1_1 - 1e-67 226.2 0.6 1.4e-67 225.9 0.6 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0556 LEM PF03020.13 MSTRG.20473.2_1 - 3.4e-14 52.0 0.2 6e-14 51.2 0.2 1.3 1 0 0 1 1 1 1 LEM domain PBP1_TM PF14812.4 MSTRG.20473.2_2 - 0.018 15.3 0.1 0.035 14.4 0.1 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Nab1 PF04902.10 MSTRG.3816.2_1 - 0.038 14.2 0.6 0.086 13.1 0.6 1.6 1 0 0 1 1 1 0 Conserved region in Nab1 Phlebovirus_NSM PF07246.9 MSTRG.3816.2_1 - 0.063 12.5 1.6 0.13 11.5 1.5 1.5 1 1 0 1 1 1 0 Phlebovirus nonstructural protein NS-M Lectin_N PF03954.12 MSTRG.3816.2_1 - 0.28 10.8 3.8 0.48 10.0 2.1 2.2 2 1 0 2 2 2 0 Hepatic lectin, N-terminal domain TBPIP PF07106.11 MSTRG.3816.2_1 - 1.6 8.4 5.4 14 5.3 0.1 3.2 3 0 0 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) GDA1_CD39 PF01150.15 MSTRG.16915.2_1 - 8.8e-74 248.5 0.0 1.1e-73 248.2 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Adhesin_E PF16747.3 MSTRG.16915.2_1 - 0.036 14.0 0.0 0.068 13.1 0.0 1.4 1 0 0 1 1 1 0 Surface-adhesin protein E Med8 PF10232.7 MSTRG.8493.1_2 - 0.16 11.4 0.5 0.21 11.0 0.5 1.1 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 Trypsin PF00089.24 MSTRG.11102.3_3 - 1.2e-56 191.9 0.2 1.4e-56 191.7 0.2 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 MSTRG.11102.3_3 - 2.9e-05 24.8 0.0 5.9e-05 23.9 0.0 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 MSTRG.11102.3_3 - 0.12 12.6 0.1 0.21 11.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) ST7 PF04184.10 MSTRG.65.2_1 - 0.33 9.2 1.3 0.63 8.3 1.3 1.3 1 0 0 1 1 1 0 ST7 protein zf-C2HC_2 PF13913.4 MSTRG.65.2_1 - 4.2 7.3 6.3 0.35 10.7 0.4 2.1 2 0 0 2 2 2 0 zinc-finger of a C2HC-type ATP-synt_ab PF00006.23 MSTRG.14570.1_2 - 2.6e-68 229.7 0.0 3.7e-68 229.2 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.21 MSTRG.14570.1_2 - 1.2e-11 44.8 0.5 2.1e-11 44.0 0.1 1.6 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain DUF2025 PF09634.8 MSTRG.25620.1_2 - 0.012 15.5 0.0 0.023 14.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2025) Sec16_C PF12931.5 MSTRG.20910.1_3 - 0.045 13.3 0.2 0.63 9.5 0.2 2.3 1 1 0 1 1 1 0 Sec23-binding domain of Sec16 WD40 PF00400.30 MSTRG.20910.1_3 - 8.5 7.3 7.4 1.8 9.4 0.0 3.9 5 0 0 5 5 5 0 WD domain, G-beta repeat FOXP-CC PF16159.3 MSTRG.13060.1_2 - 1.8e-33 114.8 4.0 1.8e-33 114.8 4.0 3.3 2 1 1 3 3 3 1 FOXP coiled-coil domain Forkhead PF00250.16 MSTRG.13060.1_2 - 5.7e-28 96.9 0.2 1.6e-27 95.5 0.2 1.8 1 0 0 1 1 1 1 Forkhead domain DUF4298 PF14131.4 MSTRG.13060.1_2 - 2.1 8.2 12.8 6.8 6.6 12.8 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4298) Amidase PF01425.19 MSTRG.1194.1_1 - 5e-124 414.6 0.0 8e-124 413.9 0.0 1.3 1 1 0 1 1 1 1 Amidase EF-hand_2 PF09068.9 MSTRG.25309.2_2 - 2.1e-41 140.8 1.2 3.2e-41 140.2 1.2 1.3 1 0 0 1 1 1 1 EF hand EF-hand_3 PF09069.9 MSTRG.25309.2_2 - 3.7e-39 132.9 0.0 8.7e-39 131.7 0.0 1.7 1 0 0 1 1 1 1 EF-hand ZZ PF00569.15 MSTRG.25309.2_2 - 5.8e-20 70.7 4.2 1.3e-19 69.6 4.2 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type WW PF00397.24 MSTRG.25309.2_2 - 0.36 10.7 3.2 0.66 9.8 3.2 1.4 1 0 0 1 1 1 0 WW domain zf-C2H2_4 PF13894.4 MSTRG.289.2_2 - 1.2e-13 50.5 23.8 0.00062 20.3 0.3 5.2 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2 PF00096.24 MSTRG.289.2_2 - 1.9e-11 43.6 27.2 0.0044 17.3 0.9 5.3 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-met PF12874.5 MSTRG.289.2_2 - 3.7e-07 30.2 13.0 0.28 11.5 0.2 4.7 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.4 MSTRG.289.2_2 - 4.4e-06 26.8 0.1 4.4e-06 26.8 0.1 4.6 4 1 0 4 4 4 1 Zinc-finger double domain zf-C2H2_jaz PF12171.6 MSTRG.289.2_2 - 5e-05 23.4 6.2 1.6 9.0 0.2 4.0 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 MSTRG.289.2_2 - 0.0015 18.1 0.1 0.0015 18.1 0.1 4.3 5 0 0 5 5 5 2 zinc-finger C2H2-type Cript PF10235.7 MSTRG.289.2_2 - 0.017 15.5 4.6 0.017 15.5 4.6 2.5 2 0 0 2 2 2 0 Microtubule-associated protein CRIPT zf-C2H2_2 PF12756.5 MSTRG.289.2_2 - 0.029 14.6 13.5 2.5 8.4 1.1 4.0 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.4 MSTRG.289.2_2 - 0.033 14.0 0.3 0.033 14.0 0.3 4.3 4 1 0 4 4 4 0 C2H2-type zinc finger zf-Di19 PF05605.10 MSTRG.289.2_2 - 0.058 13.6 6.7 0.36 11.0 0.4 3.0 1 1 2 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.13 MSTRG.289.2_2 - 0.088 12.7 0.3 0.088 12.7 0.3 3.8 2 1 2 5 5 5 0 BED zinc finger HypA PF01155.17 MSTRG.289.2_2 - 0.089 12.7 11.4 0.44 10.5 0.5 2.9 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Elf1 PF05129.11 MSTRG.289.2_2 - 0.5 10.3 13.9 0.14 12.1 0.6 3.1 1 1 2 3 3 3 0 Transcription elongation factor Elf1 like Zn-ribbon_8 PF09723.8 MSTRG.289.2_2 - 0.96 9.5 16.5 1.7 8.7 1.6 3.9 2 2 1 3 3 3 0 Zinc ribbon domain zf-Sec23_Sec24 PF04810.13 MSTRG.289.2_2 - 1.4 8.9 12.8 1 9.3 2.1 3.8 2 2 1 3 3 3 0 Sec23/Sec24 zinc finger C1_2 PF03107.14 MSTRG.289.2_2 - 1.8 8.8 16.6 39 4.5 0.2 4.9 2 1 2 5 5 5 0 C1 domain HNH_5 PF14279.4 MSTRG.289.2_2 - 2.8 7.8 10.2 2.3 8.0 0.5 4.0 4 0 0 4 4 4 0 HNH endonuclease C1_1 PF00130.20 MSTRG.289.2_2 - 8.7 6.2 20.3 12 5.8 1.8 3.8 2 1 1 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Protamine_3 PF08188.9 MSTRG.289.2_3 - 0.35 11.0 4.7 0.63 10.2 4.7 1.3 1 0 0 1 1 1 0 Spermatozal protamine family Vps5 PF09325.8 MSTRG.7763.1_3 - 1e-17 64.4 12.9 1.4e-15 57.4 12.9 2.2 1 1 0 1 1 1 1 Vps5 C terminal like PX PF00787.22 MSTRG.7763.1_3 - 1.8e-17 63.2 0.2 5.8e-17 61.6 0.2 1.9 1 0 0 1 1 1 1 PX domain Ras PF00071.20 MSTRG.11037.1_3 - 5.5e-30 104.0 0.1 9e-30 103.3 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.11037.1_3 - 7.9e-23 80.8 0.1 1.5e-22 79.9 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.11037.1_3 - 5e-09 35.7 0.1 6.8e-09 35.3 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 MSTRG.11037.1_3 - 0.00019 20.8 0.0 0.00027 20.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 MSTRG.11037.1_3 - 0.00075 18.8 0.0 0.0011 18.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 MSTRG.11037.1_3 - 0.011 15.7 0.0 0.017 15.1 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.4 MSTRG.11037.1_3 - 0.05 13.8 0.1 0.19 12.0 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain Septin PF00735.16 MSTRG.11037.1_3 - 0.056 12.5 0.0 0.097 11.7 0.0 1.3 1 0 0 1 1 1 0 Septin PduV-EutP PF10662.7 MSTRG.11037.1_3 - 0.091 12.4 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.4 MSTRG.11037.1_3 - 0.094 12.3 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain Thioredoxin PF00085.18 MSTRG.940.1_2 - 4.1e-08 33.0 0.0 1.1e-07 31.6 0.0 1.7 1 1 1 2 2 2 1 Thioredoxin OST3_OST6 PF04756.11 MSTRG.940.1_2 - 0.049 12.8 0.0 0.075 12.2 0.0 1.3 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Sec7 PF01369.18 MSTRG.4406.1_1 - 6.9e-11 42.1 0.0 1.5e-10 41.0 0.0 1.6 2 0 0 2 2 2 1 Sec7 domain IncA PF04156.12 MSTRG.4406.1_1 - 1.6 8.4 8.0 0.48 10.1 1.8 2.3 2 0 0 2 2 2 0 IncA protein Syntaxin PF00804.23 MSTRG.15803.2_3 - 1.9e-59 200.6 15.0 3.2e-59 199.8 15.0 1.4 1 0 0 1 1 1 1 Syntaxin Syntaxin_2 PF14523.4 MSTRG.15803.2_3 - 5.6e-10 39.4 6.5 5.6e-10 39.4 6.5 2.0 2 0 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.17 MSTRG.15803.2_3 - 6.8e-10 38.7 3.1 6.8e-10 38.7 3.1 3.8 4 0 0 4 4 4 1 SNARE domain DUF2207 PF09972.7 MSTRG.15803.2_3 - 0.012 14.4 0.2 0.012 14.4 0.2 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) AAA_13 PF13166.4 MSTRG.15803.2_3 - 0.052 12.1 15.8 0.071 11.6 15.8 1.1 1 0 0 1 1 1 0 AAA domain FlaC_arch PF05377.9 MSTRG.15803.2_3 - 0.14 12.4 0.2 0.14 12.4 0.2 3.6 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF3040 PF11239.6 MSTRG.15803.2_3 - 0.16 12.1 4.9 0.23 11.6 1.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Nup54 PF13874.4 MSTRG.15803.2_3 - 0.44 10.5 10.1 0.097 12.6 3.8 2.4 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 DUF5082 PF16888.3 MSTRG.15803.2_3 - 0.54 10.5 8.2 3 8.1 2.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) Baculo_PEP_C PF04513.10 MSTRG.15803.2_3 - 3.5 7.5 6.7 1.3 8.9 2.0 2.2 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TMPIT PF07851.11 MSTRG.15803.2_3 - 7.2 5.6 6.7 5.3 6.0 2.4 2.1 2 0 0 2 2 2 0 TMPIT-like protein Fib_alpha PF08702.8 MSTRG.15803.2_3 - 8.9 6.4 13.4 0.82 9.7 4.8 2.7 2 2 1 3 3 3 0 Fibrinogen alpha/beta chain family EF-hand_7 PF13499.4 MSTRG.25756.1_2 - 9.3e-28 96.4 4.2 1.6e-17 63.6 0.1 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.30 MSTRG.25756.1_2 - 9.5e-26 87.3 6.5 2.8e-07 29.5 0.0 4.3 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 MSTRG.25756.1_2 - 1.1e-21 74.8 3.1 1.7e-06 27.3 0.1 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.4 MSTRG.25756.1_2 - 1.5e-21 74.8 4.5 1.1e-06 27.7 0.3 4.3 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.4 MSTRG.25756.1_2 - 8e-17 60.6 5.3 7.3e-08 31.9 0.1 3.7 3 1 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 MSTRG.25756.1_2 - 4.2e-06 26.9 0.4 0.013 15.7 0.1 3.2 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 MSTRG.25756.1_2 - 1.2e-05 25.0 1.4 0.83 9.5 0.0 3.7 1 1 2 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.4 MSTRG.25756.1_2 - 0.099 12.8 0.1 16 5.8 0.0 2.8 3 0 0 3 3 3 0 EF-hand domain SHR-BD PF06650.10 MSTRG.20521.2_3 - 7.4e-79 264.8 0.0 5.1e-76 255.5 0.0 3.2 4 0 0 4 4 4 2 SHR-binding domain of vacuolar-sorting associated protein 13 UBA PF00627.29 MSTRG.20521.2_3 - 9e-05 22.2 0.0 0.00017 21.3 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain Pkinase_Tyr PF07714.15 MSTRG.25110.1_3 - 8.7e-60 202.0 0.0 1.2e-59 201.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.25110.1_3 - 2e-25 89.6 0.0 2.7e-25 89.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Caldesmon PF02029.13 MSTRG.5882.1_1 - 9.1e-05 21.3 26.2 0.00016 20.4 26.2 1.3 1 0 0 1 1 1 1 Caldesmon fn3 PF00041.19 MSTRG.17754.3_3 - 2.3e-147 479.6 51.7 1.5e-14 53.9 0.5 12.5 12 0 0 12 12 12 12 Fibronectin type III domain VWA PF00092.26 MSTRG.17754.3_3 - 2.8e-105 349.9 3.0 1.6e-52 178.2 1.8 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain Collagen PF01391.16 MSTRG.17754.3_3 - 1.6e-34 117.3 169.6 2.1e-08 33.6 29.8 5.4 2 2 3 5 5 5 5 Collagen triple helix repeat (20 copies) VWA_2 PF13519.4 MSTRG.17754.3_3 - 1.9e-28 99.1 0.0 1.9e-15 57.3 0.0 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain Interfer-bind PF09294.8 MSTRG.17754.3_3 - 7.4e-19 67.9 0.0 1.9 8.7 0.0 11.1 12 0 0 12 12 12 3 Interferon-alpha/beta receptor, fibronectin type III Pur_ac_phosph_N PF16656.3 MSTRG.17754.3_3 - 5.9e-16 58.7 41.7 0.1 13.0 0.2 13.1 12 2 0 12 12 11 6 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.7 MSTRG.17754.3_3 - 1.3e-13 51.1 2.1 0.97 9.8 0.0 9.7 11 0 0 11 11 11 2 Uncharacterised conserved protein (DUF2369) DUF4998 PF16389.3 MSTRG.17754.3_3 - 5.8e-09 35.7 0.3 6.6 6.1 0.0 8.3 11 0 0 11 11 11 2 Domain of unknown function DUF4992 PF16383.3 MSTRG.17754.3_3 - 0.023 14.1 0.0 0.44 9.9 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function fn3_2 PF16893.3 MSTRG.17754.3_3 - 0.061 13.3 0.1 88 3.2 0.0 4.6 5 0 0 5 5 5 0 Fibronectin type III domain SWM_repeat PF13753.4 MSTRG.17754.3_3 - 0.076 13.0 0.0 17 5.5 0.1 2.9 2 0 0 2 2 2 0 Putative flagellar system-associated repeat fn3 PF00041.19 MSTRG.3422.3_1 - 5.9e-64 212.3 12.4 1.9e-16 60.0 0.4 4.3 4 0 0 4 4 4 4 Fibronectin type III domain Ig_3 PF13927.4 MSTRG.3422.3_1 - 2.6e-24 85.5 3.1 2.2e-12 47.3 0.0 4.0 4 0 0 4 4 4 2 Immunoglobulin domain I-set PF07679.14 MSTRG.3422.3_1 - 4.6e-23 80.9 0.0 6.5e-13 48.4 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.3422.3_1 - 2.2e-17 63.0 0.2 1.3e-08 34.9 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain Pur_ac_phosph_N PF16656.3 MSTRG.3422.3_1 - 7.9e-12 45.5 8.3 0.07 13.6 0.0 5.1 4 1 0 4 4 4 4 Purple acid Phosphatase, N-terminal domain ig PF00047.23 MSTRG.3422.3_1 - 3.3e-09 36.7 0.0 0.00085 19.3 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin domain Interfer-bind PF09294.8 MSTRG.3422.3_1 - 6.6e-08 32.7 0.1 0.044 14.0 0.0 3.7 3 0 0 3 3 3 2 Interferon-alpha/beta receptor, fibronectin type III V-set PF07686.15 MSTRG.3422.3_1 - 1.7e-06 28.0 0.1 0.051 13.6 0.0 4.7 4 1 0 4 4 4 1 Immunoglobulin V-set domain DUF2369 PF10179.7 MSTRG.3422.3_1 - 0.0011 19.2 0.0 17 5.9 0.0 4.3 4 0 0 4 4 4 0 Uncharacterised conserved protein (DUF2369) C2-set_2 PF08205.10 MSTRG.3422.3_1 - 0.0029 17.5 0.7 1.3 9.0 0.0 3.2 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Reeler PF02014.14 MSTRG.3422.3_1 - 0.0096 16.5 0.0 4.5 7.9 0.0 3.2 2 1 0 3 3 3 1 Reeler domain Ig_5 PF16681.3 MSTRG.3422.3_1 - 0.014 15.6 0.0 0.45 10.8 0.0 2.4 2 0 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain GPI-anchored PF10342.7 MSTRG.3422.3_1 - 0.33 11.6 2.4 1.1 9.9 0.1 2.9 3 0 0 3 3 2 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family SSF PF00474.15 MSTRG.26406.5_3 - 3.1e-30 105.2 28.5 9.4e-16 57.5 6.1 2.1 2 0 0 2 2 2 2 Sodium:solute symporter family PLDc_2 PF13091.4 MSTRG.28242.1_1 - 9.4e-08 31.9 0.0 1.2e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 PLD-like domain Lig_chan-Glu_bd PF10613.7 MSTRG.19842.1_3 - 1.8e-27 95.6 0.0 1.4e-26 92.7 0.0 2.1 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 MSTRG.19842.1_3 - 3.1e-12 46.3 0.0 5.9e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 ANF_receptor PF01094.26 MSTRG.19842.1_3 - 9.9e-05 21.5 0.0 0.013 14.5 0.0 2.3 2 0 0 2 2 2 2 Receptor family ligand binding region Lig_chan PF00060.24 MSTRG.19842.1_3 - 0.00012 21.8 0.3 0.00018 21.2 0.3 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel TPR_MLP1_2 PF07926.10 MSTRG.7041.1_1 - 4.7e-20 71.8 29.0 4.7e-20 71.8 29.0 13.8 5 3 6 12 12 12 3 TPR/MLP1/MLP2-like protein bZIP_1 PF00170.19 MSTRG.21788.1_2 - 2.8e-15 56.0 15.1 6.4e-15 54.9 15.1 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 MSTRG.21788.1_2 - 4e-09 36.3 8.7 4e-09 36.3 8.7 2.8 2 1 1 3 3 3 1 Basic region leucine zipper bZIP_Maf PF03131.15 MSTRG.21788.1_2 - 2.4e-06 27.8 10.4 7.3e-06 26.3 10.4 1.8 1 0 0 1 1 1 1 bZIP Maf transcription factor DUF4407 PF14362.4 MSTRG.21788.1_2 - 0.091 12.0 0.9 0.11 11.7 0.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) APG6 PF04111.10 MSTRG.21788.1_2 - 0.19 11.0 4.4 0.31 10.3 4.4 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Jnk-SapK_ap_N PF09744.7 MSTRG.21788.1_2 - 0.25 11.4 6.7 0.54 10.3 6.7 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 ZapB PF06005.10 MSTRG.21788.1_2 - 0.41 11.0 4.8 0.15 12.4 1.6 1.9 2 0 0 2 2 2 0 Cell division protein ZapB DUF16 PF01519.14 MSTRG.21788.1_2 - 0.66 10.4 4.6 1.2 9.5 4.6 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF16 TPR_MLP1_2 PF07926.10 MSTRG.21788.1_2 - 0.88 9.5 8.9 2 8.4 8.9 1.5 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF4404 PF14357.4 MSTRG.21788.1_2 - 2.7 8.6 4.9 1.5 9.4 1.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) DUF724 PF05266.12 MSTRG.21788.1_2 - 3 7.5 6.6 5.9 6.5 6.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) FF PF01846.17 MSTRG.1134.1_2 - 9.3e-44 147.3 23.4 7e-17 61.2 0.2 6.1 6 0 0 6 6 6 5 FF domain WW PF00397.24 MSTRG.1134.1_2 - 1.6e-19 69.4 17.4 8.8e-10 38.2 4.4 2.7 2 0 0 2 2 2 2 WW domain RCC1 PF00415.16 MSTRG.661.1_1 - 4.5e-22 78.3 4.2 9.6e-10 38.8 0.1 3.4 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 MSTRG.661.1_1 - 9.6e-11 41.1 5.3 6.7e-05 22.5 0.2 2.7 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat TPR_12 PF13424.4 MSTRG.16042.1_2 - 3.9e-21 75.0 37.3 8.6e-08 32.2 3.0 9.2 8 1 2 10 10 10 4 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.16042.1_2 - 5.2e-12 44.9 18.2 0.00013 21.7 0.2 10.5 11 0 0 11 11 11 2 Tetratricopeptide repeat SH3_9 PF14604.4 MSTRG.16042.1_2 - 3.4e-10 39.5 0.0 9.1e-06 25.3 0.0 3.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.15 MSTRG.16042.1_2 - 4.2e-09 35.8 0.0 0.00026 20.5 0.0 2.9 2 0 0 2 2 2 2 Variant SH3 domain TPR_2 PF07719.15 MSTRG.16042.1_2 - 7.4e-09 34.9 23.8 3.4e-05 23.5 0.3 8.4 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.16042.1_2 - 9.2e-09 34.6 18.8 0.00028 20.5 0.6 7.6 7 0 0 7 7 7 2 Tetratricopeptide repeat SH3_1 PF00018.26 MSTRG.16042.1_2 - 7.3e-06 25.4 2.0 0.0027 17.1 0.1 3.2 3 0 0 3 3 3 2 SH3 domain ANAPC3 PF12895.5 MSTRG.16042.1_2 - 0.0025 17.8 1.3 0.92 9.6 0.0 3.7 3 1 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.4 MSTRG.16042.1_2 - 0.0033 17.1 25.1 0.042 13.6 1.0 8.0 9 0 0 9 9 9 1 Tetratricopeptide repeat SNAP PF14938.4 MSTRG.16042.1_2 - 0.019 14.3 0.1 0.046 13.0 0.1 1.6 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP TPR_7 PF13176.4 MSTRG.16042.1_2 - 0.042 13.7 0.0 0.042 13.7 0.0 7.5 11 0 0 11 11 9 0 Tetratricopeptide repeat TPR_5 PF12688.5 MSTRG.16042.1_2 - 0.087 12.9 0.1 0.41 10.8 0.1 2.2 1 0 0 1 1 1 0 Tetratrico peptide repeat TPR_14 PF13428.4 MSTRG.16042.1_2 - 0.19 12.5 15.3 3.8 8.5 0.0 7.9 9 0 0 9 9 7 0 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.16042.1_2 - 1.5 9.3 10.4 89 3.6 0.8 4.9 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.16042.1_2 - 8.1 7.0 9.2 22 5.6 0.4 5.9 8 0 0 8 8 7 0 Tetratricopeptide repeat zf-C4 PF00105.16 MSTRG.17581.1_2 - 3.5e-28 97.7 15.9 6.7e-28 96.8 15.9 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 MSTRG.17581.1_2 - 8.3e-27 94.0 2.4 1.6e-26 93.0 2.4 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor PDZ PF00595.22 MSTRG.18703.2_1 - 2.3e-39 133.5 5.6 4.8e-12 45.9 0.2 3.4 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.18703.2_1 - 9.6e-14 51.3 1.3 0.00035 20.7 0.1 3.5 3 0 0 3 3 3 3 PDZ domain Guanylate_kin PF00625.19 MSTRG.18703.2_1 - 4.9e-12 45.8 0.0 2e-11 43.8 0.0 1.9 1 1 1 2 2 2 1 Guanylate kinase SH3_2 PF07653.15 MSTRG.18703.2_1 - 6.4e-09 35.2 0.1 3.6e-08 32.8 0.0 2.4 3 0 0 3 3 3 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.18703.2_1 - 0.00025 20.5 0.0 0.0012 18.3 0.0 2.2 2 0 0 2 2 2 1 SH3 domain DOR PF14839.4 MSTRG.6557.1_2 - 5.2e-20 72.3 23.2 1.8e-19 70.6 19.2 2.8 1 1 1 2 2 2 1 DOR family PhoLip_ATPase_N PF16209.3 MSTRG.4957.3_3 - 3.8e-14 52.0 3.5 5.1e-14 51.6 3.5 1.2 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal LSM PF01423.20 MSTRG.15365.3_1 - 8.3e-12 44.5 0.4 1.4e-11 43.8 0.4 1.4 1 0 0 1 1 1 1 LSM domain Oscp1 PF10188.7 MSTRG.15365.3_1 - 0.004 17.2 0.0 0.0073 16.3 0.0 1.4 1 0 0 1 1 1 1 Organic solute transport protein 1 Oscp1 PF10188.7 MSTRG.15365.3_3 - 8e-61 205.0 1.9 1.3e-60 204.4 1.9 1.3 1 0 0 1 1 1 1 Organic solute transport protein 1 Calsequestrin PF01216.15 MSTRG.8161.8_1 - 1.9e-167 557.0 65.6 1.9e-166 553.7 65.6 2.0 1 1 0 1 1 1 1 Calsequestrin Thioredoxin_6 PF13848.4 MSTRG.8161.8_1 - 8.8e-19 68.0 8.2 8.4e-16 58.3 2.8 2.5 2 1 0 2 2 2 2 Thioredoxin-like domain SDA1 PF05285.10 MSTRG.8161.8_1 - 0.00075 18.9 20.2 0.0011 18.4 20.2 1.2 1 0 0 1 1 1 1 SDA1 CobT PF06213.10 MSTRG.8161.8_1 - 0.26 10.5 16.0 0.41 9.9 16.0 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Collagen PF01391.16 MSTRG.14021.1_2 - 2.3e-38 129.6 161.9 1.4e-10 40.6 26.0 4.6 2 2 3 5 5 5 5 Collagen triple helix repeat (20 copies) DcpS_C PF11969.6 MSTRG.11538.1_1 - 2.9e-32 111.4 2.7 5.4e-32 110.5 2.7 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.21 MSTRG.11538.1_1 - 2e-14 53.9 1.3 3.4e-14 53.2 1.3 1.4 1 0 0 1 1 1 1 HIT domain zf-C2HE PF16278.3 MSTRG.11538.1_1 - 6.2e-14 52.1 0.6 2e-13 50.5 0.6 1.9 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger FHA PF00498.24 MSTRG.11538.1_1 - 0.0045 17.2 0.0 0.012 15.9 0.0 1.7 1 0 0 1 1 1 1 FHA domain zf-C2H2_6 PF13912.4 MSTRG.11538.1_1 - 0.48 10.3 5.5 0.21 11.4 2.0 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger HCV_NS5a PF01506.17 MSTRG.11538.1_3 - 0.78 9.5 3.9 1.7 8.5 3.9 1.6 1 0 0 1 1 1 0 Hepatitis C virus non-structural 5a protein membrane anchor DUF1777 PF08648.10 MSTRG.23558.1_1 - 0.0018 18.4 4.2 0.0018 18.4 4.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1777) MIP-T3 PF10243.7 MSTRG.23558.1_1 - 0.021 13.5 3.2 0.026 13.1 3.2 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Atrophin-1 PF03154.13 MSTRG.23558.1_1 - 0.38 8.9 21.5 0.49 8.5 21.5 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.4 MSTRG.23558.1_1 - 7.6 6.4 17.9 14 5.5 17.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 MSTRG.23558.1_2 - 0.15 10.2 20.3 0.18 9.9 20.3 1.0 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.4 MSTRG.23558.1_2 - 2.6 7.9 14.8 4.2 7.3 14.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 MSTRG.23558.1_3 - 3.3 5.7 19.6 4.8 5.2 19.6 1.1 1 0 0 1 1 1 0 Atrophin-1 family UPF0004 PF00919.18 MSTRG.13038.1_2 - 3.1e-30 104.0 0.1 5.1e-30 103.3 0.1 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 Radical_SAM PF04055.19 MSTRG.13038.1_2 - 0.00014 22.1 0.9 0.00032 21.0 0.9 1.6 1 0 0 1 1 1 1 Radical SAM superfamily Angiomotin_C PF12240.6 MSTRG.13038.1_2 - 0.0026 17.2 1.4 0.004 16.6 1.4 1.2 1 0 0 1 1 1 1 Angiomotin C terminal LIAS_N PF16881.3 MSTRG.13038.1_2 - 0.0069 16.7 0.1 0.11 12.8 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain of lipoyl synthase of Radical_SAM family IPP-2 PF04979.12 MSTRG.10497.1_3 - 1.3e-38 132.6 15.0 1.9e-38 132.0 15.0 1.3 1 0 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) DUF3435 PF11917.6 MSTRG.10497.1_3 - 2.1 7.1 5.5 3 6.5 5.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) PH PF00169.27 MSTRG.17419.6_3 - 0.00043 20.6 0.0 0.0011 19.3 0.0 1.7 1 0 0 1 1 1 1 PH domain DUF3947 PF13135.4 MSTRG.17419.6_3 - 0.074 13.1 1.1 0.16 12.1 1.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3947) PH_9 PF15410.4 MSTRG.17419.6_3 - 0.093 13.0 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain TMC PF07810.11 MSTRG.6872.1_1 - 7.1e-41 139.1 1.5 7.1e-41 139.1 1.5 2.2 2 0 0 2 2 2 1 TMC domain CUE PF02845.14 MSTRG.27319.1_2 - 1.1e-13 50.4 0.1 2.2e-13 49.5 0.1 1.5 1 0 0 1 1 1 1 CUE domain Ras PF00071.20 MSTRG.17061.1_1 - 1.5e-44 151.3 0.1 2e-44 150.9 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.17061.1_1 - 9.2e-29 100.0 0.0 1.6e-28 99.2 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.17061.1_1 - 1.2e-11 44.2 0.1 1.8e-11 43.7 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 MSTRG.17061.1_1 - 3.5e-06 26.4 0.0 5.2e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 MSTRG.17061.1_1 - 0.0008 18.9 0.8 0.0079 15.6 0.7 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 MSTRG.17061.1_1 - 0.0076 16.2 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Oxidored_q5_N PF01059.15 MSTRG.17061.1_1 - 0.01 15.8 5.3 0.018 15.0 5.3 1.3 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase chain 4, amino terminus PduV-EutP PF10662.7 MSTRG.17061.1_1 - 0.075 12.6 0.0 1.2 8.7 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.4 MSTRG.17061.1_1 - 0.11 12.7 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain TniB PF05621.9 MSTRG.17061.1_1 - 0.12 11.5 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein R3H PF01424.20 MSTRG.6492.2_3 - 1.3e-12 47.4 0.0 6.2e-12 45.2 0.0 2.3 1 0 0 1 1 1 1 R3H domain SUZ PF12752.5 MSTRG.6492.2_3 - 6.2e-12 46.0 4.5 6.2e-12 46.0 4.5 2.6 2 0 0 2 2 2 1 SUZ domain Ribosomal_L37 PF08561.8 MSTRG.23692.1_2 - 5.3e-06 26.8 1.9 1.5e-05 25.4 1.9 1.7 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L37 HMG_box PF00505.17 MSTRG.2488.2_1 - 3.6e-50 168.1 58.6 3.8e-16 59.1 3.8 7.1 7 0 0 7 7 7 6 HMG (high mobility group) box HMG_box_5 PF14887.4 MSTRG.2488.2_1 - 2.7e-49 164.9 28.9 1.4e-47 159.4 5.0 4.0 4 0 0 4 4 4 2 HMG (high mobility group) box 5 HMG_box_2 PF09011.8 MSTRG.2488.2_1 - 2.5e-22 79.1 52.2 1.2e-06 28.9 2.9 6.7 6 0 0 6 6 6 6 HMG-box domain YABBY PF04690.11 MSTRG.2488.2_1 - 0.14 12.6 2.8 0.68 10.3 2.8 2.2 1 0 0 1 1 1 0 YABBY protein DUF1074 PF06382.9 MSTRG.2488.2_1 - 4.4 7.3 24.4 2.6 8.1 0.4 5.3 4 2 2 6 6 6 0 Protein of unknown function (DUF1074) AMP-binding PF00501.26 MSTRG.25090.1_2 - 3.4e-68 230.0 0.0 4.2e-68 229.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 MSTRG.25090.1_2 - 1e-06 29.5 0.0 2.9e-06 28.0 0.0 1.8 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain RasGEF_N PF00618.18 MSTRG.5532.1_2 - 0.0002 21.4 0.1 0.00035 20.7 0.0 1.5 2 0 0 2 2 2 1 RasGEF N-terminal motif BAR PF03114.16 MSTRG.14236.1_3 - 4e-55 186.9 9.9 5.8e-55 186.4 9.0 1.6 2 0 0 2 2 2 1 BAR domain RhoGAP PF00620.25 MSTRG.14236.1_3 - 6.1e-41 139.6 0.0 1.4e-40 138.5 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain BAR_3 PF16746.3 MSTRG.14236.1_3 - 0.0021 17.7 0.5 0.0048 16.5 0.2 1.6 1 1 0 1 1 1 1 BAR domain of APPL family BAR_2 PF10455.7 MSTRG.14236.1_3 - 0.017 14.1 3.4 0.031 13.3 3.4 1.5 1 1 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking HEM4 PF02602.13 MSTRG.4884.2_2 - 6.9e-44 149.8 0.0 8.5e-44 149.5 0.0 1.1 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD Na_Pi_cotrans PF02690.13 MSTRG.27935.1_1 - 3.6e-37 127.5 27.8 4.7e-23 81.7 8.1 2.7 2 1 0 2 2 2 2 Na+/Pi-cotransporter UPF0220 PF05255.9 MSTRG.1174.3_1 - 1.3e-47 161.3 2.3 2.1e-47 160.6 2.3 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) Bacteriocin_II PF01721.16 MSTRG.1174.3_1 - 0.025 14.5 1.1 0.055 13.5 1.1 1.6 1 0 0 1 1 1 0 Class II bacteriocin CBP_BcsF PF11120.6 MSTRG.29386.1_1 - 2.4 8.1 6.4 6.5 6.7 6.4 1.8 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsF Synapsin_N PF10581.7 MSTRG.23483.1_3 - 2e-20 72.3 4.8 3.1e-20 71.7 4.8 1.3 1 0 0 1 1 1 1 Synapsin N-terminal FAM193_C PF15914.3 MSTRG.27493.1_2 - 1.3e-30 104.7 0.8 2.8e-30 103.7 0.8 1.6 1 0 0 1 1 1 1 FAM193 family C-terminal DUF4613 PF15390.4 MSTRG.27493.1_2 - 5.5 5.1 6.2 10 4.2 6.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) DNA_photolyase PF00875.16 MSTRG.18469.1_3 - 4.7e-10 39.6 0.0 9.4e-10 38.6 0.0 1.5 1 0 0 1 1 1 1 DNA photolyase TMF_TATA_bd PF12325.6 MSTRG.28008.1_2 - 0.0056 16.7 8.8 0.0065 16.5 8.8 1.1 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding ADIP PF11559.6 MSTRG.28008.1_2 - 0.022 14.7 10.5 0.023 14.6 10.5 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Macoilin PF09726.7 MSTRG.28008.1_2 - 0.035 12.5 8.9 0.038 12.4 8.9 1.1 1 0 0 1 1 1 0 Transmembrane protein APG6 PF04111.10 MSTRG.28008.1_2 - 0.038 13.2 10.4 0.042 13.1 10.4 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 Syntaxin-6_N PF09177.9 MSTRG.28008.1_2 - 0.045 14.2 3.1 0.053 13.9 3.1 1.2 1 0 0 1 1 1 0 Syntaxin 6, N-terminal DUF2312 PF10073.7 MSTRG.28008.1_2 - 0.054 13.0 2.1 0.14 11.7 2.0 2.0 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) Reo_sigmaC PF04582.10 MSTRG.28008.1_2 - 0.16 11.2 1.8 0.18 11.0 1.8 1.0 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF1319 PF07028.9 MSTRG.28008.1_2 - 0.24 11.5 5.5 0.29 11.2 5.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1319) zf-C4H2 PF10146.7 MSTRG.28008.1_2 - 0.56 10.3 6.5 0.93 9.6 1.8 1.7 1 1 0 1 1 1 0 Zinc finger-containing protein OEP PF02321.16 MSTRG.28008.1_2 - 1.2 8.8 11.6 1.3 8.6 11.6 1.0 1 0 0 1 1 1 0 Outer membrane efflux protein bZIP_2 PF07716.13 MSTRG.28008.1_2 - 1.2 9.2 11.2 4.6 7.3 2.1 2.3 2 1 0 2 2 2 0 Basic region leucine zipper DUF972 PF06156.11 MSTRG.28008.1_2 - 1.2 9.7 8.6 1.4 9.4 8.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF972) bZIP_1 PF00170.19 MSTRG.28008.1_2 - 2 8.5 10.1 2.6 8.1 1.4 2.1 2 0 0 2 2 2 0 bZIP transcription factor DivIC PF04977.13 MSTRG.28008.1_2 - 2.1 8.0 12.0 2.8 7.7 3.2 2.2 1 1 1 2 2 2 0 Septum formation initiator Cyt-b5 PF00173.26 MSTRG.17359.1_1 - 7e-24 83.6 0.0 1.2e-23 82.9 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Lipase PF00151.17 MSTRG.23585.1_3 - 6.7e-113 377.3 0.0 1.1e-112 376.5 0.0 1.3 1 0 0 1 1 1 1 Lipase PLAT PF01477.21 MSTRG.23585.1_3 - 1.5e-17 64.1 0.1 4.6e-17 62.5 0.1 2.0 2 0 0 2 2 2 1 PLAT/LH2 domain Abhydrolase_1 PF00561.18 MSTRG.23585.1_3 - 2.5e-07 30.4 0.1 3.9e-07 29.8 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 MSTRG.23585.1_3 - 2.3e-06 28.3 0.2 3.4e-06 27.7 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family NAGLU PF05089.10 MSTRG.23585.1_3 - 0.011 14.7 0.0 0.017 13.9 0.0 1.2 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain ATP_synt_H PF05493.11 MSTRG.20862.1_1 - 3.8e-21 75.2 6.2 9.2e-21 73.9 6.2 1.7 1 0 0 1 1 1 1 ATP synthase subunit H ENTH PF01417.18 MSTRG.24126.4_3 - 4.1e-49 165.6 0.0 6.5e-49 165.0 0.0 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.14 MSTRG.24126.4_3 - 0.013 14.4 0.1 0.021 13.7 0.1 1.3 1 0 0 1 1 1 0 ANTH domain UIM PF02809.18 MSTRG.24126.4_3 - 0.018 14.8 7.0 0.035 13.9 7.0 1.5 1 0 0 1 1 1 0 Ubiquitin interaction motif DUF2002 PF09400.8 MSTRG.24126.4_3 - 0.053 13.5 0.0 0.097 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2002) GSH_synth_ATP PF03917.15 MSTRG.3107.2_2 - 7.6e-70 235.4 0.0 9.7e-70 235.1 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.13 MSTRG.3107.2_2 - 4.9e-22 78.2 0.0 7.6e-22 77.6 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic glutathione synthase L51_S25_CI-B8 PF05047.14 MSTRG.20695.1_2 - 4.9e-15 55.0 0.0 7.1e-15 54.5 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Nsp1 PF11501.6 MSTRG.20695.1_2 - 0.036 14.0 0.0 0.049 13.6 0.0 1.2 1 0 0 1 1 1 0 Non structural protein Nsp1 RVT_1 PF00078.25 MSTRG.11244.1_3 - 6.7e-11 42.0 0.0 8.9e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MT-A70 PF05063.12 MSTRG.11559.1_3 - 1.3e-59 200.9 0.0 2.1e-59 200.1 0.0 1.4 1 0 0 1 1 1 1 MT-A70 Aldedh PF00171.20 MSTRG.11731.1_2 - 2.5e-88 296.5 0.0 3e-88 296.2 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.9 MSTRG.11731.1_2 - 0.00012 21.5 0.0 0.00022 20.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1487) Aldedh PF00171.20 MSTRG.11731.1_3 - 1.1e-78 264.7 0.0 1.5e-78 264.3 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Formyl_trans_N PF00551.17 MSTRG.11731.1_3 - 2.1e-42 144.8 0.0 3.9e-42 143.9 0.0 1.4 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.16 MSTRG.11731.1_3 - 5.7e-13 48.8 0.0 1.3e-12 47.7 0.0 1.6 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain PP-binding PF00550.23 MSTRG.11731.1_3 - 8.7e-05 22.7 0.0 0.00016 21.8 0.0 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site Nuc_deoxyrib_tr PF05014.13 MSTRG.26262.1_1 - 1.9e-13 50.4 0.0 2.4e-13 50.1 0.0 1.1 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase Nuc_deoxyri_tr2 PF15891.3 MSTRG.26262.1_1 - 0.065 13.4 0.0 0.12 12.6 0.0 1.5 1 1 0 1 1 1 0 Nucleoside 2-deoxyribosyltransferase like Pkinase PF00069.23 MSTRG.23803.1_3 - 1.8e-39 135.6 0.0 2.4e-39 135.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.23803.1_3 - 9e-19 67.6 0.0 1.3e-18 67.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.3 MSTRG.23803.1_3 - 1.2e-14 54.7 0.0 2.6e-14 53.6 0.0 1.6 1 0 0 1 1 1 1 Adenylate sensor of SNF1-like protein kinase Kinase-like PF14531.4 MSTRG.23803.1_3 - 0.00045 19.5 0.0 0.00057 19.1 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.21 MSTRG.23803.1_3 - 0.12 12.2 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family HD_3 PF13023.4 MSTRG.2014.1_3 - 4.2e-44 150.2 0.4 6.3e-44 149.7 0.4 1.2 1 0 0 1 1 1 1 HD domain HD PF01966.20 MSTRG.2014.1_3 - 9.6e-06 25.7 0.8 1.9e-05 24.8 0.8 1.5 1 0 0 1 1 1 1 HD domain NAP PF00956.16 MSTRG.752.1_3 - 5.4e-35 120.7 11.5 7.5e-33 113.7 2.7 5.2 2 2 1 4 4 4 2 Nucleosome assembly protein (NAP) FAM60A PF15396.4 MSTRG.17395.1_3 - 2.2e-78 263.0 12.2 2.8e-78 262.6 12.2 1.1 1 0 0 1 1 1 1 Protein Family FAM60A DUF4502 PF14950.4 MSTRG.17395.1_3 - 0.0041 16.5 1.5 0.0054 16.1 1.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4502) Str_synth PF03088.14 MSTRG.26425.3_2 - 7.1e-24 83.6 0.0 1.9e-23 82.2 0.0 1.7 2 0 0 2 2 2 1 Strictosidine synthase SGL PF08450.10 MSTRG.26425.3_2 - 4.2e-11 42.8 0.0 6.4e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region Arylesterase PF01731.18 MSTRG.26425.3_2 - 0.0053 16.8 0.0 0.015 15.4 0.0 1.7 1 1 0 1 1 1 1 Arylesterase NHL PF01436.19 MSTRG.26425.3_2 - 0.014 15.3 0.0 1.7 8.7 0.0 3.3 3 0 0 3 3 3 0 NHL repeat PD40 PF07676.10 MSTRG.26425.3_2 - 0.08 12.8 0.0 4.8 7.1 0.1 2.5 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat VWA PF00092.26 MSTRG.19655.1_2 - 2.6e-34 118.9 0.0 3.5e-34 118.4 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.4 MSTRG.19655.1_2 - 1.2e-10 41.9 0.0 2e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Integrin_alpha2 PF08441.10 MSTRG.19655.1_3 - 1.4e-47 162.5 3.4 2e-47 162.0 3.4 1.2 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.21 MSTRG.19655.1_3 - 4.2e-20 71.4 16.8 5.4e-09 35.9 0.8 3.6 3 0 0 3 3 3 3 FG-GAP repeat VCBS PF13517.4 MSTRG.19655.1_3 - 6.6e-08 32.9 6.4 0.00043 20.7 1.9 3.0 2 2 1 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DUF1540 PF07561.9 MSTRG.22480.1_2 - 2.2 8.5 13.2 1.6 9.0 0.3 4.1 4 0 0 4 4 4 0 Domain of Unknown Function (DUF1540) zn-ribbon_14 PF16503.3 MSTRG.22480.1_2 - 9.5 5.7 10.6 22 4.5 1.7 3.5 2 0 0 2 2 2 0 Zinc-ribbon Meis_PKNOX_N PF16493.3 MSTRG.10854.2_1 - 3.2e-36 123.4 0.3 6.4e-36 122.4 0.3 1.5 1 0 0 1 1 1 1 N-terminal of Homeobox Meis and PKNOX1 Homeobox_KN PF05920.9 MSTRG.10854.2_1 - 1.8e-19 69.2 1.0 3.5e-19 68.3 1.0 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 MSTRG.10854.2_1 - 1.3e-07 31.2 0.2 2.5e-07 30.3 0.2 1.5 1 0 0 1 1 1 1 Homeobox domain IP_trans PF02121.16 MSTRG.6896.1_1 - 1.5e-99 332.4 0.2 2.1e-99 332.0 0.2 1.2 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein EF-hand_1 PF00036.30 MSTRG.16680.1_1 - 1.3e-25 86.9 12.6 4e-08 32.1 0.4 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 MSTRG.16680.1_1 - 1.9e-23 82.6 9.2 2.6e-12 46.9 1.2 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.16680.1_1 - 3.3e-22 76.3 8.8 4e-08 32.4 0.2 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.4 MSTRG.16680.1_1 - 3.6e-16 58.5 12.7 1e-09 37.9 0.2 4.2 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.16680.1_1 - 2.3e-14 52.0 11.5 0.00025 20.3 0.2 4.1 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.4 MSTRG.16680.1_1 - 1.6e-10 41.0 0.2 9.7e-06 25.7 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 MSTRG.16680.1_1 - 0.00047 19.9 5.0 0.019 14.8 0.6 2.6 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 MSTRG.16680.1_1 - 0.0029 17.8 2.0 0.079 13.2 0.5 2.2 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.11 MSTRG.16680.1_1 - 0.028 14.2 0.4 1.7 8.4 0.0 3.2 1 1 3 4 4 4 0 Caleosin related protein EF-hand_11 PF08976.9 MSTRG.16680.1_1 - 0.095 13.5 0.7 6.4 7.6 0.2 2.5 1 1 1 2 2 2 0 EF-hand domain HTH_40 PF14493.4 MSTRG.16680.1_1 - 0.11 12.8 1.8 2.4 8.6 0.1 2.2 1 1 1 2 2 2 0 Helix-turn-helix domain Ras PF00071.20 MSTRG.13931.1_2 - 7.9e-57 191.2 0.0 1e-56 190.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.13931.1_2 - 6e-23 81.2 0.0 9.2e-23 80.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.13931.1_2 - 4.4e-10 39.2 0.0 7.8e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 MSTRG.13931.1_2 - 0.00071 19.0 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 MSTRG.13931.1_2 - 0.036 13.3 0.0 0.052 12.8 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.8 MSTRG.13931.1_2 - 0.073 12.4 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit RRM_1 PF00076.20 MSTRG.10519.4_1 - 1.9e-59 197.2 8.3 7.3e-15 54.4 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.6 MSTRG.10519.4_1 - 0.00037 20.4 2.7 12 5.9 0.0 5.0 4 1 0 4 4 4 1 Limkain b1 RRM_occluded PF16842.3 MSTRG.10519.4_1 - 0.0026 17.4 3.1 16 5.3 0.1 3.9 4 0 0 4 4 4 2 Occluded RNA-recognition motif OB_RNB PF08206.9 MSTRG.10519.4_1 - 0.0061 16.1 3.9 0.5 10.0 0.3 3.2 2 0 0 2 2 2 2 Ribonuclease B OB domain DbpA PF03880.13 MSTRG.10519.4_1 - 0.0085 15.9 0.0 0.36 10.7 0.0 3.2 4 0 0 4 4 4 1 DbpA RNA binding domain Nup35_RRM_2 PF14605.4 MSTRG.10519.4_1 - 0.014 15.2 0.0 13 5.7 0.0 3.7 4 0 0 4 4 4 0 Nup53/35/40-type RNA recognition motif DUF4283 PF14111.4 MSTRG.10519.4_1 - 0.028 13.8 0.0 0.33 10.3 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4283) RRM_5 PF13893.4 MSTRG.10519.4_1 - 0.05 13.1 0.0 1.5 8.3 0.0 2.7 3 0 0 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup96 PF12110.6 MSTRG.20674.1_3 - 1.6e-91 306.3 5.1 2.5e-91 305.7 5.1 1.3 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.12 MSTRG.20674.1_3 - 4e-41 140.3 0.0 6.3e-41 139.6 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.4 MSTRG.20674.1_3 - 2.1e-06 28.4 198.7 0.00014 22.5 36.3 6.5 2 2 4 6 6 6 3 Nucleoporin FG repeat region Nup84_Nup100 PF04121.11 MSTRG.20674.1_3 - 0.098 10.7 0.4 0.51 8.3 0.0 1.9 2 0 0 2 2 2 0 Nuclear pore protein 84 / 107 Kinesin PF00225.21 MSTRG.18837.1_3 - 4.3e-106 354.5 0.8 5.7e-106 354.1 0.8 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 MSTRG.18837.1_3 - 6.3e-57 191.6 0.0 1.2e-56 190.6 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding DUF4164 PF13747.4 MSTRG.18837.1_3 - 0.023 14.8 1.1 0.05 13.8 1.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) Abi_HHR PF07815.12 MSTRG.19223.7_2 - 1.1e-34 118.2 0.5 2.1e-34 117.4 0.5 1.5 1 0 0 1 1 1 1 Abl-interactor HHR SH3_9 PF14604.4 MSTRG.19223.7_2 - 2.5e-15 55.9 0.2 5e-15 54.9 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.19223.7_2 - 7.7e-15 54.1 1.0 1.4e-14 53.2 0.1 1.9 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 MSTRG.19223.7_2 - 5e-10 38.8 0.1 9.6e-10 37.9 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain TSP_1 PF00090.17 MSTRG.1870.1_2 - 2.6e-33 113.9 129.5 2e-09 37.4 11.3 10.3 10 0 0 10 10 10 8 Thrombospondin type 1 domain ADAM_spacer1 PF05986.12 MSTRG.1870.1_2 - 8.6e-31 106.2 0.0 1.4e-30 105.6 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 DUF5037 PF16440.3 MSTRG.1870.1_2 - 0.18 11.2 0.0 0.28 10.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5037) PhoLip_ATPase_C PF16212.3 MSTRG.4956.1_1 - 2.1e-77 260.1 26.5 2.1e-77 260.1 26.5 2.2 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.24 MSTRG.4956.1_1 - 1.1e-12 48.5 0.4 5.1e-07 30.0 0.1 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.4 MSTRG.4956.1_1 - 6.2e-11 42.1 0.0 2.9e-10 40.0 0.0 2.0 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.10 MSTRG.4956.1_1 - 0.00029 20.5 0.0 0.0014 18.3 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase PhoLip_ATPase_N PF16209.3 MSTRG.4956.1_1 - 0.00057 19.5 0.9 0.00057 19.5 0.9 2.5 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.18 MSTRG.4956.1_1 - 0.0059 15.8 0.2 0.0059 15.8 0.2 2.7 3 1 0 3 3 3 1 E1-E2 ATPase CNH PF00780.20 MSTRG.16412.1_2 - 6.2e-61 206.3 0.0 9.9e-61 205.6 0.0 1.3 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.23 MSTRG.16412.1_2 - 6.8e-55 186.1 0.1 1.9e-54 184.7 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.16412.1_2 - 3.5e-29 101.7 0.0 7.5e-29 100.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase KELK PF15796.3 MSTRG.16412.1_2 - 2.6e-24 85.4 20.8 2.6e-24 85.4 20.8 7.5 5 2 1 6 6 5 1 KELK-motif containing domain of MRCK Ser/Thr protein kinase DMPK_coil PF08826.8 MSTRG.16412.1_2 - 4.1e-21 74.7 10.3 4.1e-21 74.7 10.3 7.7 6 2 2 8 8 7 1 DMPK coiled coil domain like C1_1 PF00130.20 MSTRG.16412.1_2 - 1.4e-10 40.7 5.7 3e-10 39.7 5.7 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PBD PF00786.26 MSTRG.16412.1_2 - 5.8e-07 29.7 0.4 0.0045 17.2 0.1 2.9 2 0 0 2 2 2 2 P21-Rho-binding domain Kinase-like PF14531.4 MSTRG.16412.1_2 - 2.7e-06 26.8 0.0 6.5e-06 25.5 0.0 1.6 1 0 0 1 1 1 1 Kinase-like PH PF00169.27 MSTRG.16412.1_2 - 0.00075 19.9 0.0 0.0049 17.2 0.0 2.3 2 0 0 2 2 2 1 PH domain Pkinase_C PF00433.22 MSTRG.16412.1_2 - 0.0036 17.8 1.3 0.014 15.9 1.3 2.1 1 0 0 1 1 1 1 Protein kinase C terminal domain C1_2 PF03107.14 MSTRG.16412.1_2 - 0.013 15.7 4.4 0.028 14.6 4.4 1.5 1 0 0 1 1 1 0 C1 domain DASH_Dad4 PF08650.8 MSTRG.16412.1_2 - 0.18 11.7 5.0 0.42 10.5 0.5 3.1 3 0 0 3 3 3 0 DASH complex subunit Dad4 DPPIV_N PF00930.19 MSTRG.23471.2_2 - 3.5e-91 305.5 0.0 4.4e-91 305.1 0.0 1.1 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.19 MSTRG.23471.2_2 - 7.4e-48 162.7 0.0 1.3e-47 161.9 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.16 MSTRG.23471.2_2 - 4.8e-08 32.8 0.0 8.5e-08 32.0 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.18 MSTRG.23471.2_2 - 0.00013 21.6 0.0 0.00024 20.7 0.0 1.5 1 0 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.5 MSTRG.23471.2_2 - 0.0036 17.8 0.0 0.0082 16.7 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.18 MSTRG.23471.2_2 - 0.0062 16.1 0.7 0.13 11.7 0.6 3.1 3 1 0 3 3 3 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 MSTRG.23471.2_2 - 0.035 13.2 0.0 0.067 12.3 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 AXE1 PF05448.10 MSTRG.23471.2_2 - 0.089 11.3 0.0 0.74 8.3 0.0 2.1 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) PID PF00640.21 MSTRG.18881.1_3 - 1.5e-43 148.1 0.0 2.8e-33 114.8 0.0 2.4 2 0 0 2 2 2 2 Phosphotyrosine interaction domain (PTB/PID) WW PF00397.24 MSTRG.18881.1_3 - 3.2e-06 26.8 2.7 7.6e-06 25.6 2.7 1.7 1 0 0 1 1 1 1 WW domain PTB PF08416.11 MSTRG.18881.1_3 - 0.0017 18.4 0.0 0.0085 16.1 0.0 2.0 2 0 0 2 2 2 1 Phosphotyrosine-binding domain SR-25 PF10500.7 MSTRG.12629.1_2 - 0.29 10.6 3.9 0.46 9.9 3.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein UQ_con PF00179.24 MSTRG.12629.1_3 - 2e-45 153.7 0.0 2.9e-45 153.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.4 MSTRG.12629.1_3 - 0.035 13.7 0.0 0.068 12.7 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.20 MSTRG.12629.1_3 - 0.08 13.1 0.1 0.15 12.2 0.1 1.4 1 0 0 1 1 1 0 RWD domain RhoGEF PF00621.18 MSTRG.22617.1_2 - 7.2e-44 150.1 1.2 1.1e-43 149.5 1.2 1.3 1 0 0 1 1 1 1 RhoGEF domain SH3_1 PF00018.26 MSTRG.22617.1_2 - 2.3e-08 33.4 1.3 4.1e-08 32.6 1.3 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.22617.1_2 - 4.3e-06 26.3 0.2 1.1e-05 25.1 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.22617.1_2 - 4.6e-05 22.9 0.0 8.8e-05 22.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.27 MSTRG.22617.1_2 - 0.00015 22.1 0.0 0.00037 20.8 0.0 1.7 1 0 0 1 1 1 1 PH domain ABC_tran PF00005.25 MSTRG.583.1_1 - 1e-07 32.4 0.0 1.6e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 ABC transporter DUF258 PF03193.14 MSTRG.583.1_1 - 0.00011 22.0 0.0 0.00017 21.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.4 MSTRG.583.1_1 - 0.002 17.7 0.3 0.004 16.7 0.3 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.21 MSTRG.583.1_1 - 0.0039 17.1 0.0 0.0062 16.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_23 PF13476.4 MSTRG.583.1_1 - 0.049 14.0 0.0 0.073 13.4 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.4 MSTRG.583.1_1 - 0.055 13.0 0.0 0.086 12.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 MSTRG.583.1_1 - 0.085 13.1 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 MSTRG.583.1_1 - 0.098 12.8 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC2_membrane PF01061.22 MSTRG.583.1_2 - 1.8e-29 102.6 15.9 2.4e-29 102.1 15.9 1.2 1 0 0 1 1 1 1 ABC-2 type transporter DUF1440 PF07274.10 MSTRG.583.1_2 - 2.3 8.5 4.2 17 5.6 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1440) ABC_tran PF00005.25 MSTRG.583.1_3 - 1.7e-15 57.6 0.0 2.3e-15 57.2 0.0 1.2 1 0 0 1 1 1 1 ABC transporter HCO3_cotransp PF00955.19 MSTRG.7888.3_3 - 1.2e-243 809.5 7.0 1.5e-243 809.2 7.0 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 MSTRG.7888.3_3 - 6e-106 354.0 0.0 9.5e-106 353.4 0.0 1.3 1 0 0 1 1 1 1 Band 3 cytoplasmic domain CPT PF07931.10 MSTRG.7888.3_3 - 0.055 13.2 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein DUF3796 PF12676.5 MSTRG.7888.3_3 - 0.85 9.9 5.5 0.31 11.3 0.6 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3796) PLA2_B PF01735.16 MSTRG.10695.1_1 - 2.5e-137 458.1 0.0 3e-137 457.8 0.0 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain Pkinase PF00069.23 MSTRG.5572.3_2 - 1.3e-59 201.6 0.0 1.8e-59 201.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.5572.3_2 - 9.1e-25 87.3 0.0 1.5e-24 86.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 MSTRG.5572.3_2 - 0.0092 15.8 0.1 0.015 15.1 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.12 MSTRG.5572.3_2 - 0.056 12.6 0.1 0.11 11.7 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WD40 PF00400.30 MSTRG.12005.1_1 - 2.2e-14 53.4 4.6 9.9e-06 26.1 0.5 4.5 4 0 0 4 4 4 3 WD domain, G-beta repeat F-box-like PF12937.5 MSTRG.12005.1_1 - 1.3e-08 34.4 1.1 3e-08 33.3 1.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 MSTRG.12005.1_1 - 0.00022 20.9 0.3 0.00055 19.6 0.3 1.7 1 0 0 1 1 1 1 F-box domain Mnd1 PF03962.13 MSTRG.27485.1_2 - 2.7e-68 229.4 6.8 3.4e-68 229.1 6.8 1.1 1 0 0 1 1 1 1 Mnd1 family Penicillinase_R PF03965.14 MSTRG.27485.1_2 - 5.4e-05 23.4 0.1 0.00014 22.1 0.1 1.7 1 0 0 1 1 1 1 Penicillinase repressor DUF342 PF03961.11 MSTRG.27485.1_2 - 0.0049 15.4 3.3 0.0076 14.8 3.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF342) Taxilin PF09728.7 MSTRG.27485.1_2 - 0.0086 15.2 6.9 0.011 14.9 6.9 1.1 1 0 0 1 1 1 1 Myosin-like coiled-coil protein TBPIP PF07106.11 MSTRG.27485.1_2 - 0.0093 15.6 6.3 0.014 15.1 6.3 1.2 1 0 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) RasGAP_C PF03836.13 MSTRG.27485.1_2 - 0.018 15.1 0.4 0.033 14.2 0.4 1.4 1 0 0 1 1 1 0 RasGAP C-terminus Seryl_tRNA_N PF02403.20 MSTRG.27485.1_2 - 0.057 13.5 5.6 0.12 12.5 5.6 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF4407 PF14362.4 MSTRG.27485.1_2 - 0.09 12.0 1.8 0.12 11.5 1.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DsrD PF08679.9 MSTRG.27485.1_2 - 0.094 12.9 0.3 0.35 11.0 0.2 2.0 2 0 0 2 2 2 0 Dissimilatory sulfite reductase D (DsrD) APG6 PF04111.10 MSTRG.27485.1_2 - 0.23 10.7 6.2 0.33 10.2 6.2 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Cnn_1N PF07989.9 MSTRG.27485.1_2 - 1 9.4 6.1 2.9 8.0 6.0 1.8 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 DivIC PF04977.13 MSTRG.27485.1_2 - 1.2 8.8 11.2 1.3 8.7 2.2 2.7 1 1 2 3 3 3 0 Septum formation initiator Cys_knot PF00007.20 MSTRG.14635.1_1 - 2.4e-23 82.3 9.2 3.4e-23 81.8 9.2 1.2 1 0 0 1 1 1 1 Cystine-knot domain GRAM PF02893.18 MSTRG.9257.1_3 - 2.9e-19 68.8 0.6 5.6e-19 67.9 0.6 1.4 1 0 0 1 1 1 1 GRAM domain DUF1494 PF07379.9 MSTRG.9257.1_3 - 0.017 14.8 0.0 0.034 13.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1494) Reovirus_cap PF00979.15 MSTRG.9257.1_3 - 0.053 12.6 0.0 0.077 12.0 0.0 1.1 1 0 0 1 1 1 0 Reovirus outer capsid protein, Sigma 3 PMP22_Claudin PF00822.18 MSTRG.997.1_2 - 6.4e-19 68.3 6.2 9.3e-19 67.8 6.2 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family CcmB PF03379.11 MSTRG.9129.2_2 - 0.16 11.3 0.1 0.24 10.7 0.1 1.1 1 0 0 1 1 1 0 CcmB protein EF-hand_5 PF13202.4 MSTRG.23463.1_3 - 0.69 9.4 3.6 12 5.5 0.3 2.3 2 0 0 2 2 2 0 EF hand Pkinase PF00069.23 MSTRG.24796.1_3 - 3.5e-32 111.7 0.0 3.9e-32 111.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.24796.1_3 - 2.5e-15 56.3 0.0 3e-15 56.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 MSTRG.24796.1_3 - 0.00014 21.7 0.1 0.00019 21.3 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.9 MSTRG.24796.1_3 - 0.035 13.0 0.1 0.063 12.1 0.1 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase ACT_6 PF13740.4 MSTRG.24796.1_3 - 0.089 12.7 0.0 6.4 6.7 0.0 2.5 2 0 0 2 2 2 0 ACT domain Kdo PF06293.12 MSTRG.24796.1_3 - 0.13 11.4 0.2 0.23 10.7 0.1 1.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family PIP5K PF01504.16 MSTRG.18702.2_2 - 7.1e-89 297.5 0.0 1.1e-88 296.9 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Protocadherin PF08374.9 MSTRG.18702.2_2 - 0.025 14.4 0.3 0.23 11.3 0.9 2.0 2 0 0 2 2 2 0 Protocadherin DUF3915 PF13054.4 MSTRG.18702.2_2 - 0.34 10.8 1.8 1 9.2 1.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Med6 PF04934.12 MSTRG.8889.1_1 - 9.3e-41 138.6 0.0 1.5e-40 137.9 0.0 1.3 1 0 0 1 1 1 1 MED6 mediator sub complex component Peptidase_M15 PF01427.15 MSTRG.8889.1_1 - 0.054 13.1 0.1 6 6.4 0.0 2.2 2 0 0 2 2 2 0 D-ala-D-ala dipeptidase PRIMA1 PF16101.3 MSTRG.8889.1_2 - 9.2 6.2 10.2 20 5.1 10.2 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 ELL PF10390.7 MSTRG.5520.1_3 - 2.3e-100 335.6 0.2 7.4e-100 333.9 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase II elongation factor ELL Occludin_ELL PF07303.11 MSTRG.5520.1_3 - 6.8e-29 100.4 11.6 6.8e-29 100.4 11.6 2.1 2 0 0 2 2 2 1 Occludin homology domain DSPc PF00782.18 MSTRG.16319.1_3 - 4.3e-36 123.5 0.0 6.8e-36 122.9 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 MSTRG.16319.1_3 - 0.04 13.3 0.0 0.063 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase SIR2 PF02146.15 MSTRG.24922.1_1 - 4e-24 85.4 0.0 4.9e-16 59.0 0.0 2.4 1 1 1 2 2 2 2 Sir2 family TPP_enzyme_M PF00205.20 MSTRG.24922.1_1 - 0.0038 16.8 0.1 0.022 14.4 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Pkinase PF00069.23 MSTRG.14042.1_1 - 2e-62 210.8 0.0 2.8e-62 210.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.14042.1_1 - 2.7e-39 134.9 0.0 4.2e-39 134.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 MSTRG.14042.1_1 - 7.7e-32 108.8 25.5 6.7e-17 61.0 12.0 2.8 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.22 MSTRG.14042.1_1 - 3.6e-08 33.8 0.8 6.8e-08 32.9 0.8 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain C1_2 PF03107.14 MSTRG.14042.1_1 - 0.00025 21.2 16.2 0.0013 18.9 2.7 2.7 2 0 0 2 2 2 2 C1 domain Zf_RING PF16744.3 MSTRG.14042.1_1 - 0.007 16.3 1.8 0.007 16.3 1.8 2.4 2 0 0 2 2 2 1 KIAA1045 RING finger Kinase-like PF14531.4 MSTRG.14042.1_1 - 0.016 14.4 0.0 0.047 12.9 0.0 1.8 2 0 0 2 2 2 0 Kinase-like zf-HIT PF04438.14 MSTRG.14042.1_1 - 0.79 9.5 4.1 0.64 9.8 1.2 2.5 2 0 0 2 2 2 0 HIT zinc finger DUF2318 PF10080.7 MSTRG.14042.1_1 - 1.8 8.6 14.0 0.49 10.4 4.1 2.5 1 1 0 2 2 2 0 Predicted membrane protein (DUF2318) PHD PF00628.27 MSTRG.14042.1_1 - 2.9 7.7 25.7 0.11 12.3 2.8 2.9 3 0 0 3 3 3 0 PHD-finger DZR PF12773.5 MSTRG.14042.1_1 - 4.6 7.2 17.1 1.4 8.9 3.3 3.0 3 0 0 3 3 3 0 Double zinc ribbon FYVE_2 PF02318.14 MSTRG.14042.1_1 - 4.7 7.3 14.1 0.41 10.8 3.2 2.5 1 1 1 2 2 2 0 FYVE-type zinc finger Prok-RING_1 PF14446.4 MSTRG.14042.1_1 - 7.1 6.5 14.6 1.8 8.4 3.1 3.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 ArfGap PF01412.16 MSTRG.26659.1_2 - 2.7e-40 136.9 0.8 4.7e-40 136.1 0.8 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Ank_2 PF12796.5 MSTRG.26659.1_2 - 1.4e-10 41.5 0.3 2e-05 25.0 0.2 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.26659.1_2 - 1.6e-09 37.8 2.3 2e-06 27.9 0.2 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 MSTRG.26659.1_2 - 4e-09 36.7 0.3 1.2e-05 25.7 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.26659.1_2 - 1.4e-07 31.1 0.5 0.29 11.7 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.28 MSTRG.26659.1_2 - 9e-05 22.6 0.5 0.27 11.6 0.0 3.8 4 0 0 4 4 4 1 Ankyrin repeat ELMO_CED12 PF04727.11 MSTRG.28739.1_2 - 5.2e-07 29.8 0.3 5.8e-07 29.6 0.3 1.1 1 0 0 1 1 1 1 ELMO/CED-12 family CAC1F_C PF16885.3 MSTRG.13923.1_3 - 4.1e-30 105.5 1.1 7.7e-30 104.7 1.1 1.4 1 1 0 1 1 1 1 Voltage-gated calcium channel subunit alpha, C-term TSC22 PF01166.16 MSTRG.12106.2_2 - 4.7e-27 93.9 3.4 1.3e-26 92.5 3.4 1.7 1 0 0 1 1 1 1 TSC-22/dip/bun family DUF972 PF06156.11 MSTRG.12106.2_2 - 0.0024 18.3 0.1 0.0043 17.5 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF972) ZapB PF06005.10 MSTRG.12106.2_2 - 1.9 8.8 7.6 5.4 7.4 7.6 1.7 1 1 0 1 1 1 0 Cell division protein ZapB DUF3808 PF10300.7 MSTRG.12753.2_3 - 1.4e-119 399.9 8.8 1.7e-119 399.5 8.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_6 PF13174.4 MSTRG.12753.2_3 - 0.0067 16.9 3.3 1.2 9.8 0.0 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat PEPcase_2 PF14010.4 MSTRG.12753.2_3 - 0.017 13.6 0.2 0.23 9.8 0.2 2.0 2 0 0 2 2 2 0 Phosphoenolpyruvate carboxylase TPR_2 PF07719.15 MSTRG.12753.2_3 - 0.038 14.0 4.5 4.2 7.6 0.1 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.12753.2_3 - 0.04 13.6 0.3 24 4.8 0.1 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.12753.2_3 - 0.052 13.7 0.5 5.9 7.1 0.1 3.3 2 1 2 4 4 4 0 Tetratricopeptide repeat HEPN PF05168.12 MSTRG.4330.1_3 - 5.4e-10 39.3 0.0 2e-09 37.5 0.0 2.1 1 0 0 1 1 1 1 HEPN domain DnaJ PF00226.29 MSTRG.4330.1_3 - 0.002 18.1 0.2 0.0062 16.5 0.2 1.8 1 0 0 1 1 1 1 DnaJ domain HATPase_c_3 PF13589.4 MSTRG.4330.1_3 - 0.017 14.8 0.1 4.3 7.0 0.0 3.5 2 2 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase AdoHcyase PF05221.15 MSTRG.26735.1_2 - 6.9e-110 366.7 0.0 2.9e-54 184.1 0.0 2.2 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.19 MSTRG.26735.1_2 - 1.3e-78 262.5 3.7 1.9e-78 262.0 3.7 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.17 MSTRG.26735.1_2 - 1.1e-08 34.5 0.1 1.9e-08 33.7 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.10 MSTRG.26735.1_2 - 0.00011 21.6 0.0 0.00022 20.7 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain THF_DHG_CYH_C PF02882.17 MSTRG.26735.1_2 - 0.00013 21.2 1.3 0.00038 19.7 1.3 1.7 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.18 MSTRG.26735.1_2 - 0.0046 16.9 0.1 0.01 15.8 0.1 1.5 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.19 MSTRG.26735.1_2 - 0.008 15.4 1.3 0.02 14.1 1.3 1.5 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.16 MSTRG.26735.1_2 - 0.03 14.5 0.2 0.075 13.2 0.2 1.7 1 1 0 1 1 1 0 TrkA-N domain NAD_binding_7 PF13241.4 MSTRG.26735.1_2 - 0.049 13.9 0.6 0.12 12.7 0.6 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding DDE_Tnp_ISL3 PF01610.15 MSTRG.26735.1_3 - 0.15 11.6 1.0 0.27 10.8 1.0 1.3 1 0 0 1 1 1 0 Transposase DENN PF02141.19 MSTRG.10642.1_3 - 1.4e-47 162.0 3.2 1.9e-47 161.5 3.2 1.1 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.16 MSTRG.10642.1_3 - 2.9e-09 37.5 0.6 2.9e-09 37.5 0.6 2.0 2 0 0 2 2 2 1 uDENN domain dDENN PF03455.17 MSTRG.10642.1_3 - 0.018 14.9 0.2 0.037 13.9 0.2 1.6 1 0 0 1 1 1 0 dDENN domain Pkinase PF00069.23 MSTRG.22835.1_3 - 5.2e-136 452.0 0.0 2.8e-67 226.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.22835.1_3 - 9.6e-65 218.3 0.0 1.7e-31 109.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.22835.1_3 - 1.1e-14 54.4 0.0 3.9e-06 26.3 0.0 2.6 2 1 0 2 2 2 2 Kinase-like APH PF01636.21 MSTRG.22835.1_3 - 1.8e-12 47.5 2.3 8.5e-05 22.4 0.0 4.0 2 2 2 4 4 4 3 Phosphotransferase enzyme family Kdo PF06293.12 MSTRG.22835.1_3 - 8.4e-12 44.7 1.4 1.6e-07 30.7 0.0 2.2 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_C PF00433.22 MSTRG.22835.1_3 - 2.5e-07 31.1 0.4 8.5e-07 29.4 0.4 2.0 1 0 0 1 1 1 1 Protein kinase C terminal domain RIO1 PF01163.20 MSTRG.22835.1_3 - 1.2e-06 28.1 1.6 5.8e-05 22.6 0.1 2.3 2 0 0 2 2 2 1 RIO1 family FTA2 PF13095.4 MSTRG.22835.1_3 - 7.3e-05 22.4 0.4 1.1 8.7 0.1 3.2 3 0 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.7 MSTRG.22835.1_3 - 0.0052 16.2 0.1 0.13 11.7 0.0 2.2 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL Choline_kinase PF01633.18 MSTRG.22835.1_3 - 0.067 12.6 0.0 0.36 10.2 0.0 2.0 2 0 0 2 2 2 0 Choline/ethanolamine kinase SR-25 PF10500.7 MSTRG.22835.1_3 - 0.53 9.7 10.5 1.2 8.5 10.5 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CCCAP PF15964.3 MSTRG.26288.1_1 - 0.00017 19.9 0.4 0.0002 19.7 0.4 1.0 1 0 0 1 1 1 1 Centrosomal colon cancer autoantigen protein family Y_phosphatase PF00102.25 MSTRG.21856.3_1 - 1.7e-78 263.3 0.1 2.3e-78 262.9 0.1 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.4 MSTRG.21856.3_1 - 0.00042 20.2 0.0 0.00071 19.5 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.18 MSTRG.21856.3_1 - 0.014 15.1 0.0 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain DUF2152 PF10222.7 MSTRG.20504.1_2 - 1.6e-209 697.1 0.0 1.9e-209 696.9 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2152) TPR_MLP1_2 PF07926.10 MSTRG.16556.1_1 - 0.0012 18.8 16.4 0.0012 18.8 16.4 2.4 2 1 0 2 2 2 1 TPR/MLP1/MLP2-like protein TelA PF05816.9 MSTRG.16556.1_1 - 0.072 12.0 17.6 0.0067 15.4 11.4 1.9 1 1 1 2 2 2 0 Toxic anion resistance protein (TelA) T4SS PF07996.9 MSTRG.16556.1_1 - 0.12 12.6 12.8 1.9 8.7 0.4 2.4 1 1 1 2 2 2 0 Type IV secretion system proteins CortBP2 PF09727.7 MSTRG.16556.1_1 - 1 9.1 25.3 0.056 13.2 16.7 2.1 2 0 0 2 2 2 0 Cortactin-binding protein-2 Mod_r PF07200.11 MSTRG.16556.1_1 - 1.5 8.8 27.8 0.13 12.2 12.9 2.3 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Golgin_A5 PF09787.7 MSTRG.16556.1_1 - 5.5 6.2 28.7 8.8 5.6 27.9 1.6 1 1 0 1 1 1 0 Golgin subfamily A member 5 Spc7 PF08317.9 MSTRG.16556.1_1 - 9.5 4.9 29.9 0.063 12.0 15.7 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein Ribosomal_L28 PF00830.17 MSTRG.17988.1_2 - 3.9e-07 30.0 0.0 6.5e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal L28 family His_Phos_2 PF00328.20 MSTRG.9809.5_1 - 3.8e-133 444.4 0.6 4.8e-133 444.1 0.6 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) RimK PF08443.9 MSTRG.9809.5_1 - 0.071 12.6 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 RimK-like ATP-grasp domain LRR_8 PF13855.4 MSTRG.28896.1_3 - 6.9e-21 73.7 11.6 1e-16 60.3 5.4 2.5 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.5 MSTRG.28896.1_3 - 2.6e-13 49.7 22.1 4.5e-07 29.9 1.7 3.0 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 MSTRG.28896.1_3 - 7.8e-07 28.6 0.8 1.1e-06 28.2 0.8 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_5 PF13306.4 MSTRG.28896.1_3 - 8.4e-07 28.9 0.0 1.5e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_1 PF00560.31 MSTRG.28896.1_3 - 4e-06 26.4 7.1 0.29 11.6 0.0 4.5 3 1 0 3 3 3 3 Leucine Rich Repeat LRR_6 PF13516.4 MSTRG.28896.1_3 - 7.3e-06 25.5 9.2 0.8 9.8 0.2 4.3 4 0 0 4 4 4 3 Leucine Rich repeat DUF3439 PF11921.6 MSTRG.28896.1_3 - 0.0074 16.1 2.5 0.012 15.4 2.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) HNF-1B_C PF04812.11 MSTRG.27103.2_2 - 3.4e-106 354.3 41.3 4.8e-106 353.8 41.3 1.2 1 0 0 1 1 1 1 Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus HNF-1_N PF04814.11 MSTRG.27103.2_2 - 3e-63 213.8 0.0 3e-63 213.8 0.0 2.1 2 1 1 3 3 3 1 Hepatocyte nuclear factor 1 (HNF-1), N terminus Homeobox PF00046.27 MSTRG.27103.2_2 - 2.3e-06 27.2 0.1 7e-06 25.6 0.1 1.8 1 1 0 1 1 1 1 Homeobox domain Lysis_col PF02402.14 MSTRG.28306.1_1 - 3.5 7.5 7.1 0.47 10.2 0.8 2.2 1 1 1 2 2 2 0 Lysis protein Med26 PF08711.9 MSTRG.17217.3_2 - 8.8e-15 54.4 0.8 1.9e-14 53.3 0.8 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain TFIIS_M PF07500.12 MSTRG.17217.3_2 - 4.3e-06 27.0 0.2 2.5e-05 24.6 0.0 2.1 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_M PF07500.12 MSTRG.17217.3_3 - 5.4e-27 94.3 0.3 8.4e-27 93.7 0.3 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.16 MSTRG.17217.3_3 - 1.5e-18 66.2 5.8 4.4e-18 64.7 5.8 1.9 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) PRY PF13765.4 MSTRG.22789.1_3 - 2e-15 56.0 0.0 4.8e-15 54.8 0.0 1.7 1 0 0 1 1 1 1 SPRY-associated domain zf-C3HC4_4 PF15227.4 MSTRG.22789.1_3 - 1.5e-12 47.3 7.8 1.5e-12 47.3 7.8 3.3 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.22 MSTRG.22789.1_3 - 5e-11 42.4 5.1 5e-11 42.4 5.1 4.6 4 0 0 4 4 4 1 B-box zinc finger SPRY PF00622.26 MSTRG.22789.1_3 - 8.4e-11 41.9 0.0 1.6e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 SPRY domain zf-C3HC4 PF00097.23 MSTRG.22789.1_3 - 7e-08 32.1 4.8 7e-08 32.1 4.8 3.7 4 0 0 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.22789.1_3 - 8e-08 32.0 1.9 8e-08 32.0 1.9 3.5 4 1 1 5 5 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 MSTRG.22789.1_3 - 1.6e-07 30.9 5.4 1.6e-07 30.9 5.4 3.7 4 0 0 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.22789.1_3 - 8.9e-06 25.7 6.0 8.9e-06 25.7 6.0 4.1 5 0 0 5 5 2 1 Ring finger domain zf-C3HC4_3 PF13920.4 MSTRG.22789.1_3 - 1.4e-05 24.7 3.2 1.4e-05 24.7 3.2 4.0 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) U-box PF04564.13 MSTRG.22789.1_3 - 0.00021 21.2 0.2 0.015 15.3 0.0 2.7 2 0 0 2 2 2 1 U-box domain zf-RING_5 PF14634.4 MSTRG.22789.1_3 - 0.00069 19.4 4.5 0.00069 19.4 4.5 3.6 3 1 0 3 3 2 1 zinc-RING finger domain Prok-RING_4 PF14447.4 MSTRG.22789.1_3 - 0.0025 17.5 4.6 0.0025 17.5 4.6 2.7 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.4 MSTRG.22789.1_3 - 0.0044 16.7 3.4 0.013 15.2 3.4 1.8 1 0 0 1 1 1 1 zf-RING of BARD1-type protein PI3K_P85_iSH2 PF16454.3 MSTRG.22789.1_3 - 0.0076 15.7 8.6 0.018 14.4 8.6 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain IncA PF04156.12 MSTRG.22789.1_3 - 0.023 14.3 9.8 0.039 13.6 9.8 1.3 1 0 0 1 1 1 0 IncA protein DivIVA PF05103.11 MSTRG.22789.1_3 - 0.027 14.4 8.2 0.052 13.5 8.2 1.4 1 0 0 1 1 1 0 DivIVA protein ALS2CR8 PF15299.4 MSTRG.22789.1_3 - 0.084 12.6 2.8 0.17 11.6 2.7 1.6 1 1 0 1 1 1 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 TolA_bind_tri PF16331.3 MSTRG.22789.1_3 - 0.24 11.4 2.3 0.81 9.7 2.3 1.9 1 1 0 1 1 1 0 TolA binding protein trimerisation DUF885 PF05960.9 MSTRG.22789.1_3 - 0.32 10.4 1.3 7.9 5.8 0.0 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF885) Spore_III_AB PF09548.8 MSTRG.22789.1_3 - 1.2 9.1 6.9 1.5 8.8 5.3 2.0 2 1 0 2 2 1 0 Stage III sporulation protein AB (spore_III_AB) Apolipoprotein PF01442.16 MSTRG.22789.1_3 - 1.5 8.6 12.2 0.62 9.8 9.4 1.6 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF4200 PF13863.4 MSTRG.22789.1_3 - 2 8.7 13.7 5 7.4 13.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) CLZ PF16526.3 MSTRG.22789.1_3 - 2.2 8.6 8.6 14 6.0 0.1 2.5 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF5082 PF16888.3 MSTRG.22789.1_3 - 2.6 8.3 8.7 21 5.3 8.7 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) DUF1664 PF07889.10 MSTRG.22789.1_3 - 3.4 7.5 9.1 5.5 6.9 6.2 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Swi5 PF07061.9 MSTRG.22789.1_3 - 4.2 7.4 6.2 2.5 8.1 0.8 2.5 2 0 0 2 2 2 0 Swi5 ABC_tran_CTD PF16326.3 MSTRG.22789.1_3 - 4.5 7.5 7.8 2 8.6 0.7 2.8 3 0 0 3 3 2 0 ABC transporter C-terminal domain HIP1_clath_bdg PF16515.3 MSTRG.22789.1_3 - 5.7 7.5 9.4 12 6.4 9.4 1.5 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Dpy19 PF10034.7 MSTRG.12644.1_3 - 4e-223 742.2 19.1 4.6e-223 742.0 19.1 1.0 1 0 0 1 1 1 1 Q-cell neuroblast polarisation DUF2458 PF10454.7 MSTRG.12644.1_3 - 0.17 11.4 0.0 0.33 10.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) WAP PF00095.19 MSTRG.18224.2_3 - 2.2e-05 24.6 12.2 2.2e-05 24.6 12.2 2.2 2 1 0 2 2 2 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Somatomedin_B PF01033.15 MSTRG.18224.2_3 - 0.0039 17.4 6.9 0.0039 17.4 6.9 1.7 2 0 0 2 2 2 1 Somatomedin B domain RAI1 PF08652.9 MSTRG.706.2_3 - 2e-23 82.2 0.0 3.5e-23 81.4 0.0 1.4 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease LRR_8 PF13855.4 MSTRG.20287.1_2 - 4.4e-42 141.5 29.3 4.7e-15 55.0 1.9 5.2 3 2 2 6 6 6 6 Leucine rich repeat LRR_4 PF12799.5 MSTRG.20287.1_2 - 1.3e-22 79.3 33.9 6.7e-06 26.2 7.3 6.6 2 2 6 8 8 8 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 MSTRG.20287.1_2 - 3.2e-10 38.9 31.2 1.4 9.5 1.2 9.2 7 3 1 8 8 8 5 Leucine Rich Repeat LRR_5 PF13306.4 MSTRG.20287.1_2 - 1.2e-08 34.9 0.0 0.082 12.7 0.0 3.3 2 1 0 3 3 3 3 Leucine rich repeats (6 copies) LRR_6 PF13516.4 MSTRG.20287.1_2 - 8.3e-07 28.4 37.0 0.081 12.9 0.3 9.2 10 0 0 10 10 10 5 Leucine Rich repeat LRR_9 PF14580.4 MSTRG.20287.1_2 - 2.8e-06 26.8 8.4 0.02 14.2 0.2 3.4 1 1 2 3 3 3 2 Leucine-rich repeat zf-RING_9 PF13901.4 MSTRG.10501.1_1 - 8.7e-67 224.9 13.5 1.8e-66 223.9 13.5 1.5 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon RUN PF02759.17 MSTRG.10501.1_1 - 8.2e-07 28.9 1.6 8.2e-07 28.9 1.6 2.2 2 0 0 2 2 2 1 RUN domain CMD PF02627.18 MSTRG.10501.1_1 - 0.017 15.0 0.0 0.051 13.5 0.0 1.8 1 0 0 1 1 1 0 Carboxymuconolactone decarboxylase family LRRFIP PF09738.7 MSTRG.10501.1_1 - 0.024 14.0 5.2 0.06 12.7 5.2 1.6 1 0 0 1 1 1 0 LRRFIP family ig PF00047.23 MSTRG.20146.2_2 - 0.017 15.2 0.2 0.033 14.2 0.2 1.5 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.15 MSTRG.20146.2_2 - 0.054 13.5 0.1 0.091 12.8 0.1 1.4 1 0 0 1 1 1 0 Immunoglobulin V-set domain WD40 PF00400.30 MSTRG.1357.1_1 - 3.8e-12 46.4 10.1 0.00092 19.9 0.0 6.7 7 0 0 7 7 7 3 WD domain, G-beta repeat Nucleoporin_N PF08801.9 MSTRG.1357.1_1 - 0.11 11.2 0.0 0.98 8.0 0.0 1.9 1 1 0 2 2 2 0 Nup133 N terminal like Raftlin PF15250.4 MSTRG.26530.1_1 - 1.4e-106 357.0 0.0 4e-80 269.7 0.0 2.0 1 1 1 2 2 2 2 Raftlin Kelch_1 PF01344.23 MSTRG.15870.1_3 - 2.6e-80 263.7 24.2 2.5e-15 55.6 0.7 6.9 7 0 0 7 7 7 6 Kelch motif Kelch_6 PF13964.4 MSTRG.15870.1_3 - 1.2e-35 120.5 7.2 1.1e-05 25.4 0.0 6.5 4 2 2 6 6 6 6 Kelch motif BACK PF07707.13 MSTRG.15870.1_3 - 6.6e-34 116.0 1.0 1.3e-33 115.0 1.0 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_2 PF07646.13 MSTRG.15870.1_3 - 2e-31 106.6 10.9 2e-07 30.6 0.1 6.5 6 0 0 6 6 6 5 Kelch motif BTB PF00651.29 MSTRG.15870.1_3 - 4.7e-28 97.5 0.1 8.4e-28 96.7 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.4 MSTRG.15870.1_3 - 2.3e-27 94.6 13.9 1.4e-05 25.1 0.2 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.4 MSTRG.15870.1_3 - 2.4e-24 84.9 2.3 0.0069 16.2 0.0 6.4 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.4 MSTRG.15870.1_3 - 0.00028 20.6 9.1 5.7 6.9 0.0 5.2 5 0 0 5 5 5 3 Kelch motif PfkB PF00294.22 MSTRG.7648.4_2 - 3.9e-74 249.5 0.4 4.7e-74 249.3 0.4 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.10 MSTRG.7648.4_2 - 0.0013 18.0 0.0 0.0021 17.3 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Dynein_IC2 PF11540.6 MSTRG.23284.1_2 - 1.4e-15 56.8 0.1 2.6e-15 55.9 0.1 1.5 1 0 0 1 1 1 1 Cytoplasmic dynein 1 intermediate chain 2 WD40 PF00400.30 MSTRG.23284.1_2 - 1.9e-08 34.7 7.4 0.032 15.0 1.0 6.6 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.23284.1_2 - 0.0036 17.4 0.0 0.16 12.2 0.0 2.8 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain DivIC PF04977.13 MSTRG.23284.1_2 - 0.016 14.8 0.9 0.037 13.7 0.9 1.6 1 0 0 1 1 1 0 Septum formation initiator Vfa1 PF08432.8 MSTRG.23284.1_2 - 8.3 6.6 19.7 2.3 8.4 7.4 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 IncA PF04156.12 MSTRG.1288.3_1 - 0.083 12.5 2.9 0.12 12.0 2.9 1.3 1 0 0 1 1 1 0 IncA protein DUF836 PF05768.12 MSTRG.1288.3_2 - 4.6e-05 23.6 0.1 6.6e-05 23.1 0.1 1.2 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Ank PF00023.28 MSTRG.9088.1_1 - 3.2e-07 30.3 0.4 5.9e-07 29.5 0.2 1.5 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.4 MSTRG.9088.1_1 - 1.6e-05 24.8 0.1 6.5e-05 22.9 0.1 1.9 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.5 MSTRG.9088.1_1 - 9.9e-05 22.7 0.0 0.00018 21.9 0.0 1.4 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.9088.1_1 - 0.0062 17.0 0.7 0.061 13.8 0.7 2.1 1 1 0 1 1 1 1 Ankyrin repeats (many copies) NCE101 PF11654.6 MSTRG.9088.1_1 - 0.025 14.1 0.3 0.7 9.5 0.0 2.3 2 1 1 3 3 3 0 Non-classical export protein 1 Ank_5 PF13857.4 MSTRG.9088.1_1 - 0.096 13.0 0.7 0.45 10.8 0.7 2.0 1 1 0 1 1 1 0 Ankyrin repeats (many copies) FlgD_ig PF13860.4 MSTRG.9088.1_3 - 0.074 12.8 0.1 0.1 12.3 0.1 1.2 1 0 0 1 1 1 0 FlgD Ig-like domain zf-H2C2 PF09337.8 MSTRG.194.1_1 - 0.026 14.7 0.4 0.043 14.0 0.4 1.4 1 0 0 1 1 1 0 His(2)-Cys(2) zinc finger rve PF00665.24 MSTRG.194.1_2 - 2.9e-13 49.9 0.0 4.3e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.4 MSTRG.194.1_2 - 0.022 14.4 0.0 0.041 13.5 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain Tyr-DNA_phospho PF06087.10 MSTRG.5360.2_1 - 4.9e-58 196.9 0.0 6.3e-58 196.5 0.0 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase ER-remodelling PF14755.4 MSTRG.5360.2_1 - 1 9.5 9.5 0.032 14.4 2.1 2.0 2 0 0 2 2 2 0 Intracellular membrane remodeller DUF1356 PF07092.10 MSTRG.395.3_2 - 1.4e-66 223.9 1.3 1.8e-66 223.6 1.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1356) Redoxin PF08534.8 MSTRG.395.3_3 - 0.22 11.1 2.6 3.5 7.2 0.2 2.2 2 0 0 2 2 2 0 Redoxin DnaJ PF00226.29 MSTRG.27693.1_1 - 1.9e-27 95.0 4.3 4.3e-27 93.9 4.3 1.7 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.16 MSTRG.27693.1_1 - 5.4e-25 88.1 0.0 8.6e-25 87.4 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.17 MSTRG.27693.1_1 - 1.3e-10 41.4 15.3 2.8e-10 40.3 15.3 1.7 1 0 0 1 1 1 1 DnaJ central domain Ribosomal_60s PF00428.17 MSTRG.27693.1_1 - 0.0075 16.7 0.8 0.026 14.9 0.8 1.9 1 0 0 1 1 1 1 60s Acidic ribosomal protein Anti-TRAP PF15777.3 MSTRG.27693.1_1 - 0.011 15.6 13.8 0.24 11.3 3.5 3.4 1 1 2 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein RseC_MucC PF04246.10 MSTRG.27693.1_1 - 0.021 14.6 0.2 0.021 14.6 0.2 1.7 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC MFS_1 PF07690.14 MSTRG.4494.3_1 - 3.8e-12 45.7 16.2 5.6e-12 45.1 16.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1049 PF06305.9 MSTRG.4494.3_1 - 3 7.6 5.3 10 5.9 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) Ras PF00071.20 MSTRG.8135.1_2 - 5.5e-32 110.5 0.0 7.8e-32 110.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.8135.1_2 - 1e-10 41.8 0.0 2.1e-10 40.8 0.0 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.21 MSTRG.8135.1_2 - 1.3e-05 25.1 0.0 2e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 MSTRG.8135.1_2 - 0.0002 20.8 0.0 0.0003 20.2 0.0 1.1 1 0 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.25 MSTRG.8135.1_2 - 0.029 13.8 0.0 0.61 9.4 0.0 2.1 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Arf PF00025.19 MSTRG.8135.1_2 - 0.034 13.5 0.0 0.22 10.8 0.0 1.9 2 0 0 2 2 2 0 ADP-ribosylation factor family REV PF00424.16 MSTRG.8135.1_2 - 0.09 12.7 2.6 0.21 11.5 2.6 1.6 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) TniB PF05621.9 MSTRG.8135.1_2 - 0.13 11.3 0.0 1.1 8.3 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein SRPRB PF09439.8 MSTRG.8135.1_2 - 0.16 11.3 0.0 0.3 10.4 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_24 PF13479.4 MSTRG.8135.1_2 - 0.2 11.2 0.0 0.3 10.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain Connexin PF00029.17 MSTRG.7407.1_1 - 4.1e-97 324.3 0.3 5.6e-97 323.8 0.3 1.2 1 0 0 1 1 1 1 Connexin Connexin40_C PF16791.3 MSTRG.7407.1_1 - 0.12 13.5 0.8 0.43 11.7 0.8 1.9 1 1 0 1 1 1 0 Connexin 40 C-terminal domain Peptidase_C14 PF00656.20 MSTRG.27644.2_3 - 5.3e-47 160.7 0.0 7.6e-47 160.2 0.0 1.2 1 0 0 1 1 1 1 Caspase domain CutC PF03932.12 MSTRG.4159.1_1 - 6e-76 254.3 0.1 7.6e-76 254.0 0.1 1.1 1 0 0 1 1 1 1 CutC family DUF608 PF04685.11 MSTRG.25915.1_3 - 5.6e-164 545.4 8.5 3.1e-114 381.8 3.7 2.2 2 0 0 2 2 2 2 Glycosyl-hydrolase family 116, catalytic region Glyco_hydr_116N PF12215.6 MSTRG.25915.1_3 - 1.5e-104 349.6 0.0 2.1e-104 349.1 0.0 1.2 1 0 0 1 1 1 1 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term Bac_rhamnosid PF05592.9 MSTRG.25915.1_3 - 0.045 12.1 0.3 0.07 11.4 0.3 1.2 1 0 0 1 1 1 0 Bacterial alpha-L-rhamnosidase Syntaxin PF00804.23 MSTRG.25613.2_1 - 1.2e-28 100.1 4.9 1.9e-28 99.4 4.9 1.2 1 0 0 1 1 1 1 Syntaxin Syntaxin_2 PF14523.4 MSTRG.25613.2_1 - 2.8e-05 24.3 2.7 5.2e-05 23.4 2.7 1.5 1 0 0 1 1 1 1 Syntaxin-like protein Syntaxin PF00804.23 MSTRG.25613.2_2 - 7.5e-10 38.7 0.1 1.2e-09 38.0 0.1 1.3 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.17 MSTRG.25613.2_2 - 0.00069 19.4 0.0 0.0016 18.2 0.0 1.6 1 0 0 1 1 1 1 SNARE domain Med2 PF11214.6 MSTRG.25613.2_2 - 0.093 12.8 0.2 0.22 11.6 0.2 1.5 1 0 0 1 1 1 0 Mediator complex subunit 2 RGS PF00615.17 MSTRG.18984.1_3 - 1e-12 48.2 0.0 1.4e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain PMP22_Claudin PF00822.18 MSTRG.10436.1_3 - 1.1e-32 113.0 10.9 1.6e-32 112.6 10.9 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 MSTRG.10436.1_3 - 7e-08 32.3 14.7 5.8e-07 29.3 14.7 2.1 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction TRAP_alpha PF03896.14 MSTRG.14169.1_2 - 1.6e-115 385.1 0.2 1.9e-115 384.8 0.2 1.0 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit Nop14 PF04147.10 MSTRG.14169.1_2 - 0.1 10.7 3.7 0.13 10.3 3.7 1.0 1 0 0 1 1 1 0 Nop14-like family Glycogen_syn PF05693.11 MSTRG.6450.2_2 - 0 1162.0 0.0 0 1161.7 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glyco_transf_4 PF13439.4 MSTRG.6450.2_2 - 7.8e-05 22.6 0.1 0.00014 21.8 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.18 MSTRG.6450.2_2 - 0.00036 20.0 0.0 0.0014 18.1 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.4 MSTRG.6450.2_2 - 0.002 18.4 0.0 0.029 14.7 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferases group 1 bZIP_2 PF07716.13 MSTRG.6891.1_1 - 5.7e-15 55.0 15.5 5.7e-15 55.0 15.5 2.6 3 0 0 3 3 3 1 Basic region leucine zipper bZIP_1 PF00170.19 MSTRG.6891.1_1 - 0.003 17.5 9.4 0.003 17.5 9.4 2.7 3 0 0 3 3 3 1 bZIP transcription factor bZIP_Maf PF03131.15 MSTRG.6891.1_1 - 0.035 14.5 5.8 0.087 13.2 5.8 1.6 1 0 0 1 1 1 0 bZIP Maf transcription factor BSD PF03909.15 MSTRG.6891.1_1 - 0.041 13.8 0.1 0.086 12.7 0.1 1.5 1 0 0 1 1 1 0 BSD domain PriC PF07445.10 MSTRG.6891.1_1 - 1.1 9.0 4.8 1.8 8.3 4.8 1.3 1 0 0 1 1 1 0 Primosomal replication protein priC DUF3441 PF11923.6 MSTRG.18367.3_2 - 3.3e-28 97.8 0.0 3.3e-28 97.8 0.0 3.9 4 0 0 4 4 4 1 Domain of unknown function (DUF3441) DUF814 PF05670.11 MSTRG.18367.3_2 - 2.6e-23 81.8 0.0 2.6e-23 81.8 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF814) DUF948 PF06103.9 MSTRG.18367.3_2 - 0.72 10.0 2.6 26 5.0 2.7 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) FbpA PF05833.9 MSTRG.18367.3_3 - 9.8e-34 116.7 5.5 1.3e-33 116.3 5.5 1.1 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) TORC_N PF12884.5 MSTRG.10625.1_1 - 1.2e-25 89.9 0.1 2.1e-25 89.2 0.1 1.4 1 0 0 1 1 1 1 Transducer of regulated CREB activity, N terminus Xpo1 PF08389.10 MSTRG.24213.2_3 - 2.7e-40 137.7 0.0 5.5e-39 133.5 0.0 3.0 2 1 0 2 2 2 1 Exportin 1-like protein IBN_N PF03810.17 MSTRG.24213.2_3 - 0.0059 16.4 0.0 0.029 14.1 0.0 2.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT PF02985.20 MSTRG.24213.2_3 - 0.055 13.6 0.1 4.7 7.6 0.0 4.0 3 0 0 3 3 3 0 HEAT repeat DASH_Dad3 PF08656.8 MSTRG.24213.2_3 - 0.056 13.4 0.0 0.26 11.3 0.0 2.2 2 0 0 2 2 2 0 DASH complex subunit Dad3 MIT PF04212.16 MSTRG.24213.2_3 - 0.081 12.9 0.0 0.96 9.4 0.0 2.7 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain Arm PF00514.21 MSTRG.24213.2_3 - 0.29 11.1 4.3 35 4.5 0.0 4.5 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat AbLIM_anchor PF16182.3 MSTRG.15406.2_2 - 1.9e-15 57.5 0.1 2.9e-15 56.8 0.1 1.3 1 0 0 1 1 1 1 Putative adherens-junction anchoring region of AbLIM VHP PF02209.17 MSTRG.15406.2_2 - 1.7e-14 53.5 1.1 3.7e-14 52.4 1.1 1.6 1 0 0 1 1 1 1 Villin headpiece domain AbLIM_anchor PF16182.3 MSTRG.15406.2_3 - 1.3e-40 140.3 7.0 3.7e-40 138.8 7.0 1.6 1 1 0 1 1 1 1 Putative adherens-junction anchoring region of AbLIM LIM PF00412.20 MSTRG.15406.2_3 - 1.1e-37 127.9 42.3 2.4e-13 49.9 0.7 5.4 5 1 0 5 5 5 4 LIM domain UCH PF00443.27 MSTRG.15541.1_3 - 1.1e-05 24.9 0.0 1.1e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.21 MSTRG.15541.1_3 - 0.18 11.4 0.0 0.31 10.7 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin family DUF2370 PF10176.7 MSTRG.9727.2_1 - 4e-08 33.1 3.4 5.9e-06 26.0 0.0 2.7 1 1 2 3 3 3 2 Protein of unknown function (DUF2370) Voltage_CLC PF00654.18 MSTRG.25848.1_1 - 5.7e-110 367.7 21.3 8.4e-110 367.2 21.3 1.2 1 0 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.26 MSTRG.25848.1_1 - 3.5e-12 46.4 0.5 9.8e-07 29.0 0.1 2.4 2 0 0 2 2 2 2 CBS domain DDHD PF02862.15 MSTRG.14737.1_1 - 3e-58 197.7 0.0 6.9e-58 196.5 0.0 1.7 2 0 0 2 2 2 1 DDHD domain SAM_1 PF00536.28 MSTRG.14737.1_1 - 1.7e-12 47.4 0.0 3.5e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) WWE PF02825.18 MSTRG.14737.1_1 - 1.8e-09 37.9 3.1 0.00082 19.7 0.1 2.6 1 1 1 2 2 2 2 WWE domain SAM_2 PF07647.15 MSTRG.14737.1_1 - 4.8e-06 26.4 0.0 1.1e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF676 PF05057.12 MSTRG.14737.1_1 - 0.12 11.7 0.0 4.7 6.5 0.0 2.4 2 0 0 2 2 2 0 Putative serine esterase (DUF676) Sec8_exocyst PF04048.12 MSTRG.14737.1_1 - 0.17 11.6 0.4 0.33 10.7 0.4 1.3 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain DUF3769 PF12600.6 MSTRG.24888.1_2 - 0.096 11.4 0.0 0.13 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3769) Dynein_heavy PF03028.13 MSTRG.24888.1_3 - 9.2e-133 443.8 0.0 1.1e-132 443.6 0.0 1.0 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor Mito_carr PF00153.25 MSTRG.22203.1_3 - 7.6e-62 205.1 1.3 1.9e-22 78.9 0.0 3.3 2 1 1 3 3 3 3 Mitochondrial carrier protein RRM_5 PF13893.4 MSTRG.25492.2_2 - 2e-53 179.2 0.0 2.3e-52 175.7 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.20 MSTRG.25492.2_2 - 9.9e-10 38.0 0.1 0.00026 20.6 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.6 MSTRG.25492.2_2 - 0.077 13.0 0.0 12 6.0 0.0 2.5 2 0 0 2 2 2 0 Limkain b1 Mob1_phocein PF03637.15 MSTRG.23747.1_3 - 4.3e-76 254.5 0.1 5.8e-76 254.1 0.1 1.2 1 0 0 1 1 1 1 Mob1/phocein family WD40 PF00400.30 MSTRG.19806.1_1 - 1.9e-14 53.6 4.3 0.004 17.8 0.0 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.19806.1_1 - 4.8e-07 29.9 0.0 0.0033 17.6 0.0 2.7 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 MSTRG.19806.1_1 - 0.0044 15.9 0.1 0.029 13.2 0.0 2.2 2 0 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein BNIP3 PF06553.10 MSTRG.19806.1_1 - 4.9 6.6 9.6 9.9 5.6 9.6 1.4 1 0 0 1 1 1 0 BNIP3 SQS_PSY PF00494.17 MSTRG.20228.1_3 - 1.8e-05 24.2 5.0 0.001 18.5 0.7 2.2 2 0 0 2 2 2 2 Squalene/phytoene synthase HMMR_N PF15905.3 MSTRG.20228.1_3 - 0.0081 15.5 48.0 0.016 14.6 17.5 2.8 1 1 2 3 3 3 2 Hyaluronan mediated motility receptor N-terminal DivIC PF04977.13 MSTRG.20228.1_3 - 0.0085 15.7 33.8 0.015 14.9 4.0 4.2 2 2 2 4 4 4 2 Septum formation initiator ZapB PF06005.10 MSTRG.20228.1_3 - 0.026 14.9 47.4 0.044 14.1 9.5 4.0 1 1 2 3 3 3 0 Cell division protein ZapB FadA PF09403.8 MSTRG.20228.1_3 - 0.027 14.8 6.3 0.027 14.8 6.3 3.3 1 1 2 3 3 3 0 Adhesion protein FadA RimM PF01782.16 MSTRG.20228.1_3 - 0.028 14.5 1.3 0.17 12.0 0.1 2.4 2 0 0 2 2 2 0 RimM N-terminal domain Golgin_A5 PF09787.7 MSTRG.20228.1_3 - 0.029 13.7 41.7 0.16 11.3 25.8 2.4 1 1 1 2 2 2 0 Golgin subfamily A member 5 Filament PF00038.19 MSTRG.20228.1_3 - 0.033 13.6 35.5 0.035 13.6 22.6 2.1 1 1 1 2 2 2 0 Intermediate filament protein CENP-F_leu_zip PF10473.7 MSTRG.20228.1_3 - 0.046 13.6 51.9 0.56 10.1 11.3 3.6 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Jnk-SapK_ap_N PF09744.7 MSTRG.20228.1_3 - 0.089 12.9 48.7 0.14 12.2 10.9 3.1 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 Seryl_tRNA_N PF02403.20 MSTRG.20228.1_3 - 0.14 12.2 30.9 0.23 11.6 7.8 3.6 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain TBPIP PF07106.11 MSTRG.20228.1_3 - 0.23 11.1 38.2 1.5 8.4 7.4 3.1 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) IncA PF04156.12 MSTRG.20228.1_3 - 0.24 11.0 51.8 0.095 12.3 27.9 3.1 1 1 2 3 3 3 0 IncA protein DUF948 PF06103.9 MSTRG.20228.1_3 - 0.28 11.3 19.7 0.44 10.7 1.0 3.7 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF948) Reo_sigmaC PF04582.10 MSTRG.20228.1_3 - 0.33 10.2 16.0 2.5 7.3 0.9 2.3 1 1 0 2 2 2 0 Reovirus sigma C capsid protein TMF_TATA_bd PF12325.6 MSTRG.20228.1_3 - 0.37 10.9 40.2 0.27 11.3 8.7 3.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF3584 PF12128.6 MSTRG.20228.1_3 - 0.4 8.0 35.0 0.51 7.6 35.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) RasGAP_C PF03836.13 MSTRG.20228.1_3 - 0.42 10.6 25.2 0.6 10.1 3.6 3.2 1 1 2 3 3 3 0 RasGAP C-terminus SHE3 PF17078.3 MSTRG.20228.1_3 - 0.43 10.1 30.0 1.6 8.3 16.3 2.3 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 DegS PF05384.9 MSTRG.20228.1_3 - 0.64 9.4 30.7 1 8.7 15.3 2.3 1 1 1 2 2 2 0 Sensor protein DegS Spc7 PF08317.9 MSTRG.20228.1_3 - 0.65 8.7 46.1 0.82 8.3 16.6 2.9 1 1 3 4 4 4 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.10 MSTRG.20228.1_3 - 0.65 9.9 50.9 1.8 8.5 17.0 3.4 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein DUF342 PF03961.11 MSTRG.20228.1_3 - 0.73 8.2 28.2 1.7 7.0 14.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF342) Occludin_ELL PF07303.11 MSTRG.20228.1_3 - 0.79 10.3 19.9 4.7 7.9 1.0 3.4 1 1 1 3 3 3 0 Occludin homology domain PRKG1_interact PF15898.3 MSTRG.20228.1_3 - 0.86 10.4 38.2 0.14 13.0 13.2 2.8 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF1664 PF07889.10 MSTRG.20228.1_3 - 1.1 9.1 24.9 0.84 9.5 2.6 3.6 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) APG6 PF04111.10 MSTRG.20228.1_3 - 1.2 8.3 43.7 2.3 7.4 9.9 2.5 1 1 1 2 2 2 0 Autophagy protein Apg6 DUF4164 PF13747.4 MSTRG.20228.1_3 - 1.5 9.0 33.7 0.23 11.6 5.4 4.0 1 1 3 4 4 4 0 Domain of unknown function (DUF4164) Laminin_II PF06009.10 MSTRG.20228.1_3 - 1.6 8.6 25.5 0.72 9.7 3.5 2.6 1 1 0 2 2 2 0 Laminin Domain II DUF745 PF05335.11 MSTRG.20228.1_3 - 1.9 8.0 37.2 0.063 12.9 6.8 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF745) ATG16 PF08614.9 MSTRG.20228.1_3 - 2 8.4 45.1 17 5.3 28.1 2.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Dynactin_p22 PF07426.9 MSTRG.20228.1_3 - 2.2 8.0 29.6 3.8 7.2 2.4 2.7 1 1 1 2 2 2 0 Dynactin subunit p22 AAA_13 PF13166.4 MSTRG.20228.1_3 - 2.3 6.7 28.4 4.5 5.7 28.3 1.3 1 1 0 1 1 1 0 AAA domain HIP1_clath_bdg PF16515.3 MSTRG.20228.1_3 - 2.7 8.5 47.4 0.13 12.8 9.4 3.4 1 1 2 3 3 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 LPP PF04728.11 MSTRG.20228.1_3 - 2.7 8.3 16.7 3.3 8.0 2.9 4.3 3 2 0 3 3 3 0 Lipoprotein leucine-zipper Fez1 PF06818.13 MSTRG.20228.1_3 - 4 7.7 37.3 1.3 9.3 22.4 2.6 1 1 2 3 3 3 0 Fez1 DUF4250 PF14056.4 MSTRG.20228.1_3 - 4.1 7.3 9.1 13 5.7 0.2 3.8 4 0 0 4 4 3 0 Domain of unknown function (DUF4250) Kinetocho_Slk19 PF12709.5 MSTRG.20228.1_3 - 4.1 7.8 30.0 0.19 12.1 3.8 4.1 2 2 1 3 3 3 0 Central kinetochore-associated STAT_alpha PF01017.18 MSTRG.20228.1_3 - 4.9 6.8 38.0 1.4 8.6 5.2 3.1 1 1 2 3 3 3 0 STAT protein, all-alpha domain bZIP_1 PF00170.19 MSTRG.20228.1_3 - 9 6.3 37.7 2.1 8.4 8.6 4.3 2 1 2 4 4 4 0 bZIP transcription factor Spc24 PF08286.9 MSTRG.20228.1_3 - 9.1 6.4 37.2 1.3 9.2 6.2 3.6 1 1 2 3 3 3 0 Spc24 subunit of Ndc80 FlaC_arch PF05377.9 MSTRG.20228.1_3 - 9.7 6.5 20.0 8.4 6.7 0.4 4.5 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) Ufd2P_core PF10408.7 MSTRG.18257.2_3 - 8e-198 658.8 14.8 1e-197 658.5 14.8 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.13 MSTRG.18257.2_3 - 2.5e-28 97.9 1.0 6.7e-28 96.5 1.0 1.8 1 0 0 1 1 1 1 U-box domain Peptidase_A22B PF04258.11 MSTRG.24820.2_3 - 7.7e-62 209.2 6.2 1e-61 208.8 6.2 1.1 1 0 0 1 1 1 1 Signal peptide peptidase AmoA PF05145.10 MSTRG.24820.2_3 - 0.0084 15.0 3.7 0.014 14.2 3.7 1.3 1 0 0 1 1 1 1 Putative ammonia monooxygenase SPP PF06550.9 MSTRG.24820.2_3 - 0.075 12.4 4.6 0.19 11.0 4.6 1.6 1 1 0 1 1 1 0 Signal-peptide peptidase, presenilin aspartyl protease Presenilin PF01080.15 MSTRG.24820.2_3 - 8.7 4.8 11.7 0.35 9.4 4.2 1.9 2 0 0 2 2 2 0 Presenilin BNIP2 PF12496.6 MSTRG.19727.1_3 - 3.3e-30 105.2 0.0 6.6e-30 104.2 0.0 1.5 1 0 0 1 1 1 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CRAL_TRIO_2 PF13716.4 MSTRG.19727.1_3 - 3.6e-29 101.5 0.1 5.2e-29 101.0 0.1 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.18 MSTRG.19727.1_3 - 5.6e-08 32.5 0.1 1e-07 31.7 0.1 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain PI3K_P85_iSH2 PF16454.3 MSTRG.5005.1_1 - 1.2e-59 200.3 18.4 1.8e-59 199.8 18.4 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain SH2 PF00017.22 MSTRG.5005.1_1 - 4.3e-40 135.5 0.0 1.6e-19 69.6 0.0 2.6 2 0 0 2 2 2 2 SH2 domain RhoGAP PF00620.25 MSTRG.5005.1_1 - 1.2e-13 51.0 0.0 5.6e-12 45.6 0.0 2.9 2 1 0 2 2 2 1 RhoGAP domain SH3_1 PF00018.26 MSTRG.5005.1_1 - 0.0003 20.2 0.6 0.00095 18.6 0.0 2.2 2 0 0 2 2 2 1 SH3 domain AAA_13 PF13166.4 MSTRG.5005.1_1 - 0.0014 17.3 11.6 0.0019 16.8 11.6 1.1 1 0 0 1 1 1 1 AAA domain Lant_dehydr_C PF14028.4 MSTRG.5005.1_1 - 0.011 15.2 0.6 0.011 15.2 0.6 1.6 2 0 0 2 2 2 0 Lantibiotic biosynthesis dehydratase C-term SH3_9 PF14604.4 MSTRG.5005.1_1 - 0.021 14.5 0.1 0.055 13.2 0.1 1.8 1 0 0 1 1 1 0 Variant SH3 domain SH3_2 PF07653.15 MSTRG.5005.1_1 - 0.028 14.0 0.0 0.078 12.6 0.0 1.8 1 0 0 1 1 1 0 Variant SH3 domain Laminin_I PF06008.12 MSTRG.5005.1_1 - 0.035 13.7 7.1 0.068 12.7 7.1 1.4 1 0 0 1 1 1 0 Laminin Domain I Mod_r PF07200.11 MSTRG.5005.1_1 - 0.046 13.7 13.1 0.78 9.7 5.7 2.4 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein RNA_binding PF01877.15 MSTRG.5005.1_1 - 0.055 13.6 3.2 0.11 12.6 3.2 1.4 1 0 0 1 1 1 0 RNA binding IncA PF04156.12 MSTRG.5005.1_1 - 0.14 11.8 9.7 0.31 10.7 9.7 1.6 1 0 0 1 1 1 0 IncA protein PhoU PF01895.17 MSTRG.5005.1_1 - 1.2 9.5 6.5 30 5.0 0.0 3.3 2 1 1 3 3 3 0 PhoU domain TFIIIC_delta PF12657.5 MSTRG.26259.1_1 - 0.022 14.6 0.1 0.03 14.1 0.1 1.2 1 0 0 1 1 1 0 Transcription factor IIIC subunit delta N-term Spectrin PF00435.19 MSTRG.7861.7_1 - 1.4e-06 28.6 33.3 0.00046 20.5 3.1 5.2 2 2 1 4 4 4 2 Spectrin repeat CorA PF01544.16 MSTRG.7861.7_1 - 0.013 14.7 24.7 0.034 13.3 8.3 3.1 1 1 2 3 3 3 0 CorA-like Mg2+ transporter protein Na_Ca_ex_C PF16494.3 MSTRG.7861.7_1 - 0.02 15.2 0.5 0.02 15.2 0.5 3.6 2 1 1 3 3 3 0 C-terminal extension of sodium/calcium exchanger domain Zot PF05707.10 MSTRG.7861.7_1 - 0.022 14.2 0.1 0.062 12.8 0.1 1.7 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) GM_CSF PF01109.15 MSTRG.7861.7_1 - 1 9.4 7.1 3.1 7.9 0.0 3.5 4 1 0 4 4 4 0 Granulocyte-macrophage colony-stimulating factor Prominin PF05478.9 MSTRG.7861.7_1 - 1.1 7.0 21.8 0.84 7.4 12.3 2.6 2 1 0 2 2 2 0 Prominin DUF4407 PF14362.4 MSTRG.7861.7_1 - 1.4 8.1 33.4 0.18 11.0 4.8 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) DASH_Dam1 PF08653.8 MSTRG.7861.7_1 - 2.6 7.8 9.2 14 5.5 0.1 4.7 5 1 1 6 6 6 0 DASH complex subunit Dam1 DUF948 PF06103.9 MSTRG.7861.7_1 - 4.3 7.5 17.1 3.6 7.8 0.9 4.6 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) PhyH PF05721.11 MSTRG.20584.1_1 - 6.3e-48 163.7 0.0 8.3e-48 163.3 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 7tm_1 PF00001.19 MSTRG.19142.1_2 - 5.3e-44 150.3 14.9 6.8e-44 150.0 14.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) IR1-M PF12185.6 MSTRG.14865.1_2 - 0.14 12.0 0.1 0.21 11.4 0.1 1.3 1 0 0 1 1 1 0 Nup358/RanBP2 E3 ligase domain DUF1878 PF08963.8 MSTRG.7649.1_2 - 0.011 16.0 0.2 0.013 15.9 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1878) DUF3731 PF12531.6 MSTRG.7649.1_2 - 0.1 12.2 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 DNA-K related protein OB_NTP_bind PF07717.14 MSTRG.1628.3_3 - 2.2e-20 72.7 0.0 5.5e-20 71.5 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.21 MSTRG.1628.3_3 - 3.4e-19 69.0 0.0 1e-18 67.4 0.0 1.9 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.29 MSTRG.1628.3_3 - 1.5e-13 50.9 0.0 6e-13 49.0 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RWD PF05773.20 MSTRG.1628.3_3 - 1.3e-11 44.7 0.0 2.8e-11 43.6 0.0 1.6 1 0 0 1 1 1 1 RWD domain DEAD PF00270.27 MSTRG.1628.3_3 - 1.5e-09 37.8 0.1 2.6e-09 36.9 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-CCCH PF00642.22 MSTRG.1628.3_3 - 6.7e-06 25.7 5.0 6.7e-06 25.7 5.0 2.9 4 0 0 4 4 4 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) AAA_22 PF13401.4 MSTRG.1628.3_3 - 0.00067 19.8 0.1 0.0019 18.4 0.1 1.8 1 0 0 1 1 1 1 AAA domain Torus PF16131.3 MSTRG.1628.3_3 - 0.009 16.6 2.0 0.015 15.8 0.3 2.1 2 0 0 2 2 2 1 Torus domain NB-ARC PF00931.20 MSTRG.1628.3_3 - 0.022 13.7 0.0 0.061 12.2 0.0 1.7 2 0 0 2 2 2 0 NB-ARC domain Viral_helicase1 PF01443.16 MSTRG.1628.3_3 - 0.061 12.9 0.0 0.19 11.3 0.0 1.8 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase zf-CCCH_2 PF14608.4 MSTRG.1628.3_3 - 0.091 13.1 2.7 0.33 11.4 2.7 2.1 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger AAA_14 PF13173.4 MSTRG.1628.3_3 - 0.096 12.6 0.0 0.62 10.0 0.0 2.3 1 1 0 1 1 1 0 AAA domain UBA PF00627.29 MSTRG.1628.3_3 - 0.099 12.4 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 UBA/TS-N domain AAA_19 PF13245.4 MSTRG.1628.3_3 - 0.13 12.5 0.0 0.29 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain V-set PF07686.15 MSTRG.4510.1_1 - 7.5e-28 96.7 0.0 5.3e-14 52.2 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.23 MSTRG.4510.1_1 - 2.7e-10 40.2 0.3 1.9e-05 24.6 0.1 3.5 2 2 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.4510.1_1 - 7.5e-08 32.8 0.0 0.00028 21.3 0.1 3.4 3 1 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 MSTRG.4510.1_1 - 1.7e-06 27.9 0.0 0.0061 16.5 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.4510.1_1 - 0.00033 20.8 0.4 0.13 12.4 0.1 3.4 3 0 0 3 3 3 1 Immunoglobulin domain Izumo-Ig PF16706.3 MSTRG.4510.1_1 - 0.0056 16.6 0.1 2.3 8.2 0.1 2.5 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain DUF4381 PF14316.4 MSTRG.4510.1_1 - 0.057 13.5 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) BatD PF13584.4 MSTRG.4510.1_1 - 0.21 10.3 0.0 0.35 9.6 0.0 1.3 1 0 0 1 1 1 0 Oxygen tolerance WT1 PF02165.13 MSTRG.26482.1_2 - 3.7 6.6 11.9 5.6 6.0 11.9 1.2 1 0 0 1 1 1 0 Wilm's tumour protein WT1 PF02165.13 MSTRG.26482.1_3 - 7.6 5.5 13.7 9.8 5.2 13.7 1.1 1 0 0 1 1 1 0 Wilm's tumour protein TIG PF01833.22 MSTRG.18275.1_1 - 4.5e-36 122.7 9.9 4.3e-13 49.0 0.1 6.1 6 0 0 6 6 6 4 IPT/TIG domain PSI PF01437.23 MSTRG.18275.1_1 - 2.9e-06 27.6 33.4 0.0021 18.4 10.3 2.8 2 0 0 2 2 2 2 Plexin repeat SKG6 PF08693.8 MSTRG.18275.1_1 - 0.36 10.2 5.4 0.82 9.0 5.4 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain A_deamin PF02137.16 MSTRG.12555.2_1 - 3.2e-103 345.5 0.0 5.2e-103 344.8 0.0 1.3 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain dsrm PF00035.24 MSTRG.12555.2_1 - 2.7e-30 104.7 0.0 1.2e-08 35.4 0.0 4.1 3 1 0 3 3 3 3 Double-stranded RNA binding motif z-alpha PF02295.15 MSTRG.12555.2_1 - 7.9e-20 70.5 0.6 2.1e-09 37.1 0.1 2.6 2 0 0 2 2 2 2 Adenosine deaminase z-alpha domain HTH_9 PF08221.9 MSTRG.12555.2_1 - 0.02 14.8 1.8 4.1 7.5 0.2 2.6 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 helix-turn-helix domain DUF4589 PF15252.4 MSTRG.5489.1_2 - 2.2e-81 273.4 5.4 2.2e-81 273.4 5.4 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4589) CENP_C_N PF15622.4 MSTRG.5489.1_2 - 0.014 14.7 0.2 0.025 13.9 0.2 1.3 1 0 0 1 1 1 0 Kinetochore assembly subunit CENP-C N-terminal zf-RING_10 PF16685.3 MSTRG.5489.1_2 - 1.2 9.2 6.1 4.7 7.3 0.0 2.6 2 0 0 2 2 2 0 zinc RING finger of MSL2 Hydrolase_4 PF12146.6 MSTRG.2834.1_2 - 3.5e-13 49.3 0.0 1.6e-07 30.7 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.18 MSTRG.2834.1_2 - 3.1e-06 26.9 0.0 0.022 14.3 0.1 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 MSTRG.2834.1_2 - 4.6e-06 26.1 0.0 8.1e-05 22.1 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.5 MSTRG.2834.1_2 - 4.8e-06 27.2 0.0 0.0035 17.9 0.0 2.2 1 1 1 2 2 2 2 Alpha/beta hydrolase family DUF818 PF05677.10 MSTRG.2834.1_2 - 0.00078 18.4 0.1 0.0012 17.8 0.1 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) UPF0227 PF05728.10 MSTRG.2834.1_2 - 0.0026 17.6 0.0 0.02 14.7 0.0 2.1 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0227) Abhydrolase_5 PF12695.5 MSTRG.2834.1_2 - 0.0028 17.3 0.0 0.0071 16.0 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.11 MSTRG.2834.1_2 - 0.015 14.9 0.0 0.023 14.2 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.14 MSTRG.2834.1_2 - 0.015 15.0 0.0 0.11 12.2 0.0 2.0 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase DLH PF01738.16 MSTRG.2834.1_2 - 0.018 14.4 0.0 0.029 13.8 0.0 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family Asp2 PF16929.3 MSTRG.2834.1_2 - 0.051 12.5 0.0 0.076 11.9 0.0 1.2 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter RhoGAP PF00620.25 MSTRG.17235.1_3 - 1.5e-49 167.6 0.0 2.7e-49 166.8 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.20 MSTRG.17235.1_3 - 9.3e-16 57.3 6.5 9.3e-16 57.3 6.5 2.7 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH2 PF00017.22 MSTRG.17235.1_3 - 8.9e-12 44.8 0.0 2e-11 43.6 0.0 1.6 1 0 0 1 1 1 1 SH2 domain C1_2 PF03107.14 MSTRG.17235.1_3 - 0.12 12.6 7.8 0.94 9.7 3.1 2.8 2 0 0 2 2 2 0 C1 domain PHD_2 PF13831.4 MSTRG.17235.1_3 - 2 7.9 14.2 0.63 9.5 2.6 2.8 2 0 0 2 2 2 0 PHD-finger Mago-bind PF09282.8 MSTRG.4478.2_2 - 1.3e-13 50.4 3.0 2.8e-13 49.4 3.0 1.5 1 0 0 1 1 1 1 Mago binding DUF4782 PF16016.3 MSTRG.5556.1_1 - 1.5e-33 116.2 2.8 2.9e-33 115.3 2.8 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4782) GRAM PF02893.18 MSTRG.5556.1_1 - 1.7e-18 66.4 0.1 4e-18 65.2 0.1 1.7 1 0 0 1 1 1 1 GRAM domain Ank_2 PF12796.5 MSTRG.6605.2_3 - 4.3e-55 184.1 18.4 7.5e-13 48.8 0.4 6.3 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.6605.2_3 - 1.4e-33 114.6 14.7 1.1e-07 32.1 0.2 8.1 6 2 2 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.6605.2_3 - 6.9e-31 105.2 18.4 0.0003 21.0 0.0 10.4 10 0 0 10 10 10 9 Ankyrin repeat Ank_3 PF13606.4 MSTRG.6605.2_3 - 1.2e-28 95.8 14.1 0.0018 18.5 0.0 11.4 11 0 0 11 11 11 7 Ankyrin repeat Ank_5 PF13857.4 MSTRG.6605.2_3 - 4.2e-18 65.0 21.4 0.00076 19.7 0.1 8.9 6 4 5 11 11 11 7 Ankyrin repeats (many copies) SOCS_box PF07525.14 MSTRG.6605.2_3 - 5.3e-11 42.5 4.5 1.3e-10 41.3 4.5 1.7 1 0 0 1 1 1 1 SOCS box DUF3447 PF11929.6 MSTRG.6605.2_3 - 0.11 12.4 0.0 3 7.7 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3447) Peptidase_C48 PF02902.17 MSTRG.26790.3_1 - 3.6e-33 115.1 0.2 5.9e-33 114.4 0.2 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Cadherin PF00028.15 MSTRG.19133.1_2 - 2.4e-25 88.7 0.0 6.3e-17 61.7 0.0 2.4 2 0 0 2 2 2 2 Cadherin domain Cadherin_C_2 PF16492.3 MSTRG.19133.1_2 - 4.9e-21 75.2 3.8 4.9e-21 75.2 3.8 2.2 2 1 0 2 2 2 1 Cadherin cytoplasmic C-terminal DUF1191 PF06697.10 MSTRG.19133.1_2 - 0.069 12.2 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) TMEM154 PF15102.4 MSTRG.19133.1_2 - 0.42 10.4 1.6 0.52 10.1 0.0 1.9 2 0 0 2 2 2 0 TMEM154 protein family ROKNT PF08067.9 MSTRG.19659.1_1 - 2.3e-17 62.8 1.3 4.6e-17 61.9 1.3 1.4 1 0 0 1 1 1 1 ROKNT (NUC014) domain KH_4 PF13083.4 MSTRG.19659.1_1 - 4.9e-05 23.0 0.0 8.4e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 KH domain KH_1 PF00013.27 MSTRG.19659.1_1 - 0.00044 19.9 0.0 0.00082 19.0 0.0 1.4 1 0 0 1 1 1 1 KH domain KH_2 PF07650.15 MSTRG.19659.1_1 - 0.0026 17.4 0.1 0.0047 16.6 0.1 1.3 1 0 0 1 1 1 1 KH domain KH_1 PF00013.27 MSTRG.19659.1_2 - 2.7e-31 107.0 7.5 2.4e-19 68.8 2.5 2.3 2 0 0 2 2 2 2 KH domain KH_2 PF07650.15 MSTRG.19659.1_2 - 7.4e-08 32.0 2.0 0.00094 18.8 0.5 2.4 2 0 0 2 2 2 2 KH domain KH_5 PF13184.4 MSTRG.19659.1_2 - 0.009 15.9 2.4 0.39 10.7 0.2 2.8 3 0 0 3 3 3 1 NusA-like KH domain DJ-1_PfpI PF01965.22 MSTRG.19659.1_2 - 0.094 12.4 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 DJ-1/PfpI family Metallophos PF00149.26 MSTRG.7239.1_2 - 5.7e-33 115.0 0.3 8.7e-33 114.4 0.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.3 MSTRG.7239.1_2 - 0.012 15.9 0.2 0.03 14.6 0.2 1.7 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Spectrin PF00435.19 MSTRG.26464.1_3 - 1e-61 205.8 25.6 4.8e-20 71.9 7.2 4.4 4 0 0 4 4 4 4 Spectrin repeat CH PF00307.29 MSTRG.26464.1_3 - 2.6e-53 178.7 0.9 7.2e-27 93.6 0.0 2.9 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.8 MSTRG.26464.1_3 - 1.4e-25 89.1 0.0 4.7e-25 87.3 0.0 2.0 1 0 0 1 1 1 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.6 MSTRG.26464.1_3 - 4.2e-09 36.0 0.1 4.7e-08 32.6 0.0 2.5 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_1 PF00036.30 MSTRG.26464.1_3 - 2.9e-07 29.4 0.9 0.022 14.2 0.2 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 MSTRG.26464.1_3 - 0.00015 21.3 0.6 0.021 14.6 0.1 2.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.4 MSTRG.26464.1_3 - 0.00024 20.7 0.7 0.0011 18.6 0.3 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.4 MSTRG.26464.1_3 - 0.0004 20.7 0.6 0.0012 19.2 0.1 2.2 2 0 0 2 2 2 1 EF-hand domain pair DUF724 PF05266.12 MSTRG.26464.1_3 - 0.47 10.1 10.9 0.25 11.0 1.8 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF724) RabGAP-TBC PF00566.16 MSTRG.246.1_1 - 3.1e-59 200.1 6.6 4.5e-59 199.6 6.6 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF659 PF04937.13 MSTRG.198.1_3 - 3.8e-05 23.4 0.0 4.7e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) MULE PF10551.7 MSTRG.198.1_3 - 0.0046 17.3 0.0 0.0056 17.0 0.0 1.3 1 1 0 1 1 1 1 MULE transposase domain DDDD PF10161.7 MSTRG.198.1_3 - 0.018 14.6 0.0 0.025 14.2 0.0 1.2 1 0 0 1 1 1 0 Putative mitochondrial precursor protein Aminotran_3 PF00202.19 MSTRG.17911.3_1 - 1.5e-12 46.8 0.0 1.9e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Mod_r PF07200.11 MSTRG.11455.3_2 - 6.9e-39 133.1 9.8 6.9e-39 133.1 9.8 1.6 2 0 0 2 2 2 1 Modifier of rudimentary (Mod(r)) protein UEV PF05743.11 MSTRG.11455.3_2 - 0.062 13.0 1.7 1.8 8.3 0.3 2.5 2 0 0 2 2 2 0 UEV domain Prominin PF05478.9 MSTRG.27531.1_2 - 1.3e-25 89.4 6.2 1.4e-25 89.3 6.2 1.0 1 0 0 1 1 1 1 Prominin EphA2_TM PF14575.4 MSTRG.27531.1_2 - 0.15 12.7 0.1 0.2 12.4 0.1 1.2 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Corona_S2 PF01601.14 MSTRG.27531.1_2 - 0.18 10.1 2.4 0.19 10.0 2.4 1.0 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Mucin PF01456.15 MSTRG.27531.1_2 - 2.7 7.9 6.0 2.9 7.7 6.0 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein LRR_8 PF13855.4 MSTRG.25022.1_2 - 1.7e-20 72.4 26.9 5.2e-10 38.8 4.0 4.5 2 1 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.5 MSTRG.25022.1_2 - 2.4e-12 46.7 31.3 1.2e-05 25.4 3.1 6.5 2 2 4 7 7 7 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 MSTRG.25022.1_2 - 0.00017 21.0 4.3 0.041 13.2 0.3 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.31 MSTRG.25022.1_2 - 0.057 13.8 32.2 10 6.9 0.1 8.4 9 0 0 9 9 9 0 Leucine Rich Repeat LRR_6 PF13516.4 MSTRG.25022.1_2 - 0.22 11.5 19.5 12 6.1 0.2 6.8 7 0 0 7 7 7 0 Leucine Rich repeat FCH PF00611.21 MSTRG.27382.1_1 - 9.6e-16 57.7 1.3 9.6e-16 57.7 1.3 3.2 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.4 MSTRG.27382.1_1 - 2.3e-09 36.8 0.0 4.5e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.27382.1_1 - 3.5e-09 36.0 0.0 7.9e-09 34.8 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.27382.1_1 - 1.4e-06 27.7 0.0 2.7e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 MSTRG.27382.1_1 - 0.0035 17.5 0.0 0.0063 16.6 0.0 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain KxDL PF10241.7 MSTRG.27382.1_1 - 0.0078 16.3 1.9 0.0078 16.3 1.9 3.9 4 0 0 4 4 4 1 Uncharacterized conserved protein DUF1664 PF07889.10 MSTRG.27382.1_1 - 4.1 7.3 9.4 7.6 6.4 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) OppC_N PF12911.5 MSTRG.23977.1_1 - 0.011 15.5 0.0 0.024 14.5 0.0 1.4 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C Trypan_PARP PF05887.9 MSTRG.23977.1_2 - 2.1 8.3 13.2 0.76 9.7 4.6 2.6 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Methyltransf_34 PF11312.6 MSTRG.23977.1_3 - 0.19 10.8 0.4 0.28 10.2 0.4 1.1 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase Ribosomal_60s PF00428.17 MSTRG.3467.1_1 - 4.9e-27 94.2 5.6 7.7e-27 93.6 5.6 1.3 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF3824 PF12868.5 MSTRG.3467.1_1 - 0.22 12.1 2.5 0.38 11.3 2.5 1.3 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) zf-RING_9 PF13901.4 MSTRG.1146.1_1 - 1.1e-65 221.3 11.6 1.8e-65 220.6 11.6 1.4 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon PH PF00169.27 MSTRG.1146.1_1 - 0.018 15.4 0.0 0.032 14.6 0.0 1.5 1 0 0 1 1 1 0 PH domain IP_trans PF02121.16 MSTRG.24695.4_3 - 3.7e-117 390.1 2.5 4.9e-117 389.7 2.5 1.1 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein Mis14 PF08641.10 MSTRG.8266.1_1 - 9.5e-14 51.7 3.1 2.9e-13 50.1 3.1 1.8 1 1 0 1 1 1 1 Kinetochore protein Mis14 like APO_RNA-bind PF05634.9 MSTRG.8266.1_1 - 0.057 12.7 0.1 0.11 11.7 0.1 1.4 1 0 0 1 1 1 0 APO RNA-binding BAG PF02179.14 MSTRG.14740.1_1 - 1.4e-18 66.9 4.7 2.5e-18 66.1 4.7 1.4 1 0 0 1 1 1 1 BAG domain WW PF00397.24 MSTRG.14740.1_1 - 1e-09 38.0 1.1 2.5e-09 36.8 1.1 1.7 1 0 0 1 1 1 1 WW domain ERM PF00769.17 MSTRG.24967.9_3 - 0.0028 17.4 17.0 0.0028 17.4 17.0 9.1 4 3 5 9 9 9 1 Ezrin/radixin/moesin family SAM_1 PF00536.28 MSTRG.19434.1_3 - 7.7e-17 61.4 0.0 1.2e-16 60.7 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 MSTRG.19434.1_3 - 1.6e-12 47.2 0.0 2.5e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SEFIR PF08357.9 MSTRG.16493.1_3 - 6.9e-18 65.2 0.0 1.2e-17 64.4 0.0 1.4 1 0 0 1 1 1 1 SEFIR domain TIR_2 PF13676.4 MSTRG.16493.1_3 - 0.00042 20.5 0.0 0.00076 19.7 0.0 1.4 1 0 0 1 1 1 1 TIR domain Piwi PF02171.15 MSTRG.16632.1_2 - 9.3e-84 281.1 0.4 2.4e-83 279.7 0.0 1.8 2 0 0 2 2 2 1 Piwi domain PAZ PF02170.20 MSTRG.16632.1_2 - 1.3e-30 105.8 0.2 2.8e-30 104.8 0.2 1.5 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.8 MSTRG.16632.1_2 - 8.2e-09 34.8 0.0 4.7e-08 32.4 0.0 2.3 2 0 0 2 2 2 1 Argonaute linker 1 domain ArgoN PF16486.3 MSTRG.16632.1_2 - 0.13 12.9 0.0 0.3 11.7 0.0 1.7 1 0 0 1 1 1 0 N-terminal domain of argonaute Imm_superinfect PF14373.4 MSTRG.16632.1_3 - 0.18 11.6 1.3 0.41 10.5 1.3 1.6 1 0 0 1 1 1 0 Superinfection immunity protein I-set PF07679.14 MSTRG.3833.4_1 - 8.5e-51 169.8 0.0 2.6e-16 59.3 0.0 4.3 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.3833.4_1 - 3.1e-47 159.0 4.4 4.5e-14 52.7 0.3 4.8 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.3833.4_1 - 1.2e-31 108.7 7.4 1.3e-09 38.1 0.0 5.2 5 0 0 5 5 5 4 Immunoglobulin domain ig PF00047.23 MSTRG.3833.4_1 - 4.2e-28 97.2 1.2 1.7e-11 44.0 0.0 4.6 4 0 0 4 4 4 4 Immunoglobulin domain C2-set_2 PF08205.10 MSTRG.3833.4_1 - 2.1e-10 40.4 0.8 0.038 13.9 0.0 3.7 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain V-set PF07686.15 MSTRG.3833.4_1 - 8.3e-09 35.4 7.3 0.17 11.9 0.0 6.3 5 3 0 6 6 6 3 Immunoglobulin V-set domain fn3 PF00041.19 MSTRG.3833.4_3 - 7.3e-76 250.4 11.4 2.5e-14 53.3 0.1 6.9 6 0 0 6 6 6 6 Fibronectin type III domain Ig_3 PF13927.4 MSTRG.3833.4_3 - 4e-63 209.9 4.4 1.9e-12 47.5 0.0 6.4 6 0 0 6 6 5 5 Immunoglobulin domain I-set PF07679.14 MSTRG.3833.4_3 - 1.1e-61 204.7 0.0 6.3e-12 45.3 0.0 6.2 6 0 0 6 6 6 5 Immunoglobulin I-set domain ig PF00047.23 MSTRG.3833.4_3 - 1.5e-41 140.3 0.7 2.3e-08 33.9 0.0 5.9 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.3833.4_3 - 2.1e-40 136.8 1.5 7.5e-09 35.7 0.0 6.1 5 0 0 5 5 5 5 Immunoglobulin domain V-set PF07686.15 MSTRG.3833.4_3 - 7.6e-18 64.5 5.5 0.021 14.8 0.1 8.0 5 4 1 6 6 6 4 Immunoglobulin V-set domain C2-set_2 PF08205.10 MSTRG.3833.4_3 - 3.2e-14 52.6 0.2 0.026 14.4 0.0 5.8 5 0 0 5 5 5 2 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 MSTRG.3833.4_3 - 2.3e-08 34.2 0.0 0.18 12.1 0.0 5.4 5 0 0 5 5 5 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Pur_ac_phosph_N PF16656.3 MSTRG.3833.4_3 - 3.1e-07 30.7 15.1 1.8 9.0 0.0 6.9 7 0 0 7 7 6 4 Purple acid Phosphatase, N-terminal domain C1-set PF07654.13 MSTRG.3833.4_3 - 2.5e-06 27.8 0.0 4.4 7.7 0.1 5.1 5 0 0 5 5 4 2 Immunoglobulin C1-set domain Interfer-bind PF09294.8 MSTRG.3833.4_3 - 9.8e-06 25.7 0.2 0.14 12.4 0.0 4.3 4 0 0 4 4 3 1 Interferon-alpha/beta receptor, fibronectin type III fn3_2 PF16893.3 MSTRG.3833.4_3 - 1.8e-05 24.7 0.0 0.76 9.8 0.0 4.4 5 0 0 5 5 4 2 Fibronectin type III domain Izumo-Ig PF16706.3 MSTRG.3833.4_3 - 0.0002 21.2 0.1 0.91 9.5 0.0 4.0 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain Sp38 PF07354.10 MSTRG.3833.4_3 - 0.0065 15.2 0.0 0.21 10.3 0.0 2.2 2 0 0 2 2 2 1 Zona-pellucida-binding protein (Sp38) Receptor_2B4 PF11465.6 MSTRG.3833.4_3 - 0.04 14.0 0.0 0.46 10.6 0.0 2.7 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 ChitinaseA_N PF08329.8 MSTRG.3833.4_3 - 0.066 12.7 0.0 0.18 11.3 0.0 1.7 1 0 0 1 1 1 0 Chitinase A, N-terminal domain fn3_4 PF16794.3 MSTRG.3833.4_3 - 0.1 12.4 0.0 1.7e+02 2.0 0.0 4.2 4 0 0 4 4 4 0 Fibronectin-III type domain DUF1461 PF07314.9 MSTRG.3833.4_3 - 0.12 12.2 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1461) TYA PF01021.17 MSTRG.5797.2_3 - 0.015 15.5 0.1 0.023 14.9 0.1 1.2 1 0 0 1 1 1 0 TYA transposon protein zf-H2C2_2 PF13465.4 MSTRG.25381.1_3 - 3.4e-12 46.1 10.1 2.1e-07 30.9 3.3 5.6 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.25381.1_3 - 1.9e-11 43.6 32.1 1.8e-06 27.9 0.8 4.5 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.25381.1_3 - 4.4e-05 23.8 11.7 0.0016 18.9 0.8 5.7 5 0 0 5 5 5 3 C2H2-type zinc finger zf-LYAR PF08790.9 MSTRG.25381.1_3 - 0.26 11.1 3.8 2.9 7.8 1.1 2.7 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-C2H2_6 PF13912.4 MSTRG.25381.1_3 - 8.9 6.3 18.2 0.83 9.5 0.3 4.2 3 0 0 3 3 3 0 C2H2-type zinc finger ENTH PF01417.18 MSTRG.6914.3_1 - 7.4e-51 171.3 0.3 1.3e-50 170.5 0.3 1.4 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.14 MSTRG.6914.3_1 - 0.00032 19.7 0.2 0.00047 19.1 0.2 1.2 1 0 0 1 1 1 1 ANTH domain VHS PF00790.17 MSTRG.6914.3_1 - 0.15 11.8 0.2 0.25 11.0 0.2 1.3 1 0 0 1 1 1 0 VHS domain UIM PF02809.18 MSTRG.6914.3_1 - 1 9.3 14.1 0.093 12.6 5.9 2.6 2 0 0 2 2 2 0 Ubiquitin interaction motif BaffR-Tall_bind PF09256.8 MSTRG.18328.3_1 - 0.046 13.4 4.2 2 8.1 0.2 3.4 3 0 0 3 3 3 0 BAFF-R, TALL-1 binding MARVEL PF01284.21 MSTRG.18328.3_2 - 4.2e-12 46.2 19.5 4.2e-12 46.2 19.5 1.9 2 1 0 2 2 2 1 Membrane-associating domain Claudin_3 PF06653.9 MSTRG.18328.3_2 - 0.36 10.6 12.7 0.95 9.2 12.8 1.7 1 1 0 1 1 1 0 Tight junction protein, Claudin-like zf-RING_UBOX PF13445.4 MSTRG.13006.1_3 - 4.9e-08 32.7 6.8 1.8e-07 30.9 6.8 2.1 1 0 0 1 1 1 1 RING-type zinc-finger IBR PF01485.19 MSTRG.13006.1_3 - 1.2e-05 25.3 20.2 0.00019 21.5 2.6 4.2 4 0 0 4 4 4 2 IBR domain, a half RING-finger domain zf-RanBP PF00641.16 MSTRG.13006.1_3 - 4.7e-05 22.5 0.7 0.0003 19.9 0.7 2.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others ubiquitin PF00240.21 MSTRG.13006.1_3 - 5.6e-05 22.7 0.0 0.0002 20.9 0.0 1.9 1 0 0 1 1 1 1 Ubiquitin family zf-RING_5 PF14634.4 MSTRG.13006.1_3 - 6.3e-05 22.7 8.0 6.3e-05 22.7 8.0 4.0 4 0 0 4 4 4 1 zinc-RING finger domain zf-RING_2 PF13639.4 MSTRG.13006.1_3 - 0.00043 20.4 8.9 0.00043 20.4 8.9 4.3 4 1 1 5 5 5 1 Ring finger domain zf-RING_11 PF17123.3 MSTRG.13006.1_3 - 0.0074 15.8 3.3 0.0074 15.8 3.3 2.9 3 0 0 3 3 3 1 RING-like zinc finger 4_1_CTD PF05902.11 MSTRG.18852.3_1 - 5.2e-43 145.5 8.4 7e-43 145.0 8.4 1.2 1 0 0 1 1 1 1 4.1 protein C-terminal domain (CTD) Dodecin PF07311.10 MSTRG.18852.3_1 - 0.059 13.5 0.5 0.11 12.6 0.5 1.4 1 0 0 1 1 1 0 Dodecin NAC PF01849.16 MSTRG.9592.1_3 - 1e-21 76.6 0.1 2.1e-21 75.6 0.1 1.6 1 0 0 1 1 1 1 NAC domain ANAPC10 PF03256.14 MSTRG.22850.3_2 - 0.029 13.9 0.1 0.048 13.2 0.1 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex, subunit 10 (APC10) ubiquitin PF00240.21 MSTRG.22850.3_3 - 2.5e-70 232.0 4.2 2.2e-34 116.9 0.3 2.1 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.6 MSTRG.22850.3_3 - 2e-34 117.1 4.6 1.8e-16 59.6 0.4 2.1 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 MSTRG.22850.3_3 - 6.7e-14 52.0 1.4 1.4e-05 25.3 0.1 3.2 2 2 0 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 MSTRG.22850.3_3 - 1.9e-07 31.0 0.3 0.03 14.3 0.0 2.7 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 MSTRG.22850.3_3 - 1.2e-05 25.7 0.0 0.24 11.8 0.0 2.3 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Telomere_Sde2 PF13019.4 MSTRG.22850.3_3 - 0.00048 19.9 0.0 0.94 9.2 0.0 2.1 1 1 1 2 2 2 2 Telomere stability and silencing FERM_f0 PF16511.3 MSTRG.22850.3_3 - 0.0045 17.1 3.2 14 6.0 0.2 3.9 2 2 0 2 2 2 0 N-terminal or F0 domain of Talin-head FERM DUF2870 PF11069.6 MSTRG.22850.3_3 - 0.0053 16.9 0.0 6.2 7.1 0.0 2.7 2 2 0 2 2 2 2 Protein of unknown function (DUF2870) RBD PF02196.13 MSTRG.22850.3_3 - 0.024 14.6 0.0 10 6.2 0.0 2.3 2 0 0 2 2 2 0 Raf-like Ras-binding domain PI3K_rbd PF00794.16 MSTRG.22850.3_3 - 0.032 14.3 1.1 5.9 7.0 0.1 2.5 2 1 0 2 2 2 0 PI3-kinase family, ras-binding domain FlgD_ig PF13860.4 MSTRG.22850.3_3 - 0.046 13.4 0.3 14 5.5 0.0 2.4 2 0 0 2 2 2 0 FlgD Ig-like domain DUF3861 PF12977.5 MSTRG.22850.3_3 - 0.073 13.1 0.1 15 5.7 0.0 2.3 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) TraK PF06586.9 MSTRG.22850.3_3 - 0.098 12.2 0.0 5.4 6.5 0.0 2.1 2 0 0 2 2 2 0 TraK protein Plexin_cytopl PF08337.10 MSTRG.22850.3_3 - 0.18 10.3 2.0 6.9 5.1 0.1 2.7 2 1 0 2 2 2 0 Plexin cytoplasmic RasGAP domain DUF456 PF04306.11 MSTRG.21784.1_1 - 0.00025 21.2 1.0 0.00037 20.6 1.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF456) Gly-zipper_YMGG PF13441.4 MSTRG.21784.1_1 - 0.0038 16.8 3.9 0.0055 16.3 3.9 1.2 1 0 0 1 1 1 1 YMGG-like Gly-zipper DUF1269 PF06897.10 MSTRG.21784.1_1 - 0.033 14.4 1.5 0.033 14.4 1.5 1.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1269) Gly-zipper_Omp PF13488.4 MSTRG.21784.1_1 - 0.1 12.5 5.2 0.18 11.8 5.2 1.3 1 0 0 1 1 1 0 Glycine zipper p450 PF00067.20 MSTRG.10416.1_3 - 5.3e-32 111.0 0.0 1.2e-31 109.9 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 Peptidase_C2 PF00648.19 MSTRG.17972.2_2 - 3.1e-84 282.3 0.0 3.9e-84 282.0 0.0 1.1 1 0 0 1 1 1 1 Calpain family cysteine protease Arf PF00025.19 MSTRG.1481.1_3 - 1.4e-64 216.6 0.6 1.9e-64 216.2 0.6 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 MSTRG.1481.1_3 - 2.4e-14 53.5 0.2 3.3e-14 53.0 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 MSTRG.1481.1_3 - 1.5e-12 47.2 0.1 1.9e-12 46.9 0.1 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.8 MSTRG.1481.1_3 - 3e-11 43.0 0.1 4e-11 42.5 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 MSTRG.1481.1_3 - 5.5e-08 32.2 0.4 5e-05 22.5 0.2 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 MSTRG.1481.1_3 - 4.7e-06 26.0 0.2 5.9e-06 25.7 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 MSTRG.1481.1_3 - 5.7e-06 26.3 0.1 8.3e-06 25.7 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 MSTRG.1481.1_3 - 0.013 14.9 0.2 0.055 12.9 0.0 1.8 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA_14 PF13173.4 MSTRG.1481.1_3 - 0.18 11.7 0.0 0.3 11.0 0.0 1.5 1 1 0 1 1 1 0 AAA domain TniB PF05621.9 MSTRG.1481.1_3 - 0.19 10.8 0.0 0.26 10.3 0.0 1.1 1 0 0 1 1 1 0 Bacterial TniB protein FeoB_N PF02421.16 MSTRG.1481.1_3 - 0.38 10.2 1.5 0.69 9.3 0.5 1.9 2 1 0 2 2 2 0 Ferrous iron transport protein B bZIP_1 PF00170.19 MSTRG.27400.1_1 - 1.8e-11 43.8 13.5 3.7e-11 42.8 13.5 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 MSTRG.27400.1_1 - 0.00042 20.2 15.8 0.001 19.0 15.8 1.7 1 0 0 1 1 1 1 Basic region leucine zipper Nop53 PF07767.9 MSTRG.27400.1_1 - 0.0094 15.3 7.4 0.014 14.7 7.4 1.2 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) IncA PF04156.12 MSTRG.27400.1_1 - 0.023 14.3 1.6 0.036 13.7 1.6 1.2 1 0 0 1 1 1 0 IncA protein Ndc1_Nup PF09531.8 MSTRG.27400.1_1 - 4.3 5.8 5.2 6.3 5.2 5.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF1041 PF06292.15 MSTRG.14526.1_3 - 2.1e-24 85.7 0.3 4.7e-24 84.6 0.3 1.7 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1041) Dexa_ind PF15198.4 MSTRG.14526.1_3 - 1.1 9.3 3.1 2.4 8.2 3.1 1.5 1 0 0 1 1 1 0 Dexamethasone-induced CD225 PF04505.10 MSTRG.7924.1_3 - 8.2e-21 73.8 1.8 8.2e-21 73.8 1.8 2.7 2 0 0 2 2 2 1 Interferon-induced transmembrane protein zf-C2H2 PF00096.24 MSTRG.24622.2_2 - 4.1e-22 77.2 50.5 7.8e-06 25.9 3.3 6.2 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.24622.2_2 - 2.3e-17 62.4 46.3 4.9e-06 26.6 0.7 6.9 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.24622.2_2 - 1.2e-10 41.1 60.3 0.0018 18.8 1.9 6.8 7 0 0 7 7 5 5 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.24622.2_2 - 5.9e-06 26.0 41.5 0.00012 21.8 1.3 6.2 7 0 0 7 7 7 4 C2H2-type zinc finger C1_4 PF07975.10 MSTRG.24622.2_2 - 9.4e-06 25.7 16.4 0.12 12.6 1.4 3.9 2 1 1 3 3 3 3 TFIIH C1-like domain Zn-ribbon_8 PF09723.8 MSTRG.24622.2_2 - 7.9e-05 22.6 18.7 0.077 13.0 1.4 3.7 3 0 0 3 3 3 2 Zinc ribbon domain zf-C2H2_jaz PF12171.6 MSTRG.24622.2_2 - 8.5e-05 22.6 24.6 0.12 12.6 1.4 5.5 5 0 0 5 5 4 3 Zinc-finger double-stranded RNA-binding GAGA PF09237.9 MSTRG.24622.2_2 - 0.0018 17.9 14.2 0.22 11.2 0.3 4.1 1 1 3 4 4 4 2 GAGA factor zf-met PF12874.5 MSTRG.24622.2_2 - 0.0065 16.7 31.4 0.036 14.3 1.1 5.3 5 0 0 5 5 5 2 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.4 MSTRG.24622.2_2 - 0.015 15.0 1.4 0.015 15.0 1.4 4.9 5 0 0 5 5 4 0 zinc-finger of a C2HC-type zf-AN1 PF01428.14 MSTRG.24622.2_2 - 0.024 14.7 27.8 0.29 11.2 3.2 5.7 4 1 1 5 5 5 0 AN1-like Zinc finger Rad50_zn_hook PF04423.12 MSTRG.24622.2_2 - 0.026 14.2 0.0 0.07 12.8 0.0 1.7 1 0 0 1 1 1 0 Rad50 zinc hook motif DUF3268 PF11672.6 MSTRG.24622.2_2 - 0.33 11.1 9.5 0.52 10.5 0.6 2.7 1 1 1 3 3 3 0 zinc-finger-containing domain zinc_ribbon_15 PF17032.3 MSTRG.24622.2_2 - 1.2 9.8 14.5 1.5 9.5 0.8 3.3 1 1 3 4 4 4 0 zinc-ribbon family zf-RING_7 PF02591.13 MSTRG.24622.2_2 - 2.6 8.2 6.7 15 5.7 0.0 4.1 4 0 0 4 4 4 0 C4-type zinc ribbon domain XPA_N PF01286.16 MSTRG.24622.2_2 - 2.7 8.0 16.5 0.59 10.1 0.8 4.6 5 0 0 5 5 5 0 XPA protein N-terminal zf-CHCC PF10276.7 MSTRG.24622.2_2 - 3.8 7.5 9.8 12 6.0 0.0 4.1 4 0 0 4 4 4 0 Zinc-finger domain HypA PF01155.17 MSTRG.24622.2_2 - 4.3 7.3 13.0 19 5.2 7.5 3.0 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA PDZ PF00595.22 MSTRG.4200.1_2 - 9e-29 99.5 1.9 2.9e-18 65.8 0.2 2.2 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_assoc PF10600.7 MSTRG.4200.1_2 - 8.3e-22 77.7 9.4 1.2e-21 77.1 9.4 1.3 1 0 0 1 1 1 1 PDZ-associated domain of NMDA receptors PDZ_2 PF13180.4 MSTRG.4200.1_2 - 4.6e-05 23.5 0.2 0.0037 17.4 0.1 2.2 2 0 0 2 2 2 1 PDZ domain BRCA-2_OB1 PF09103.8 MSTRG.4200.1_2 - 0.087 12.6 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 THOC7 PF05615.11 MSTRG.13702.1_2 - 1.7e-39 135.0 6.3 3.1e-38 130.9 0.1 2.1 1 1 1 2 2 2 1 Tho complex subunit 7 Suppressor_APC PF11414.6 MSTRG.13702.1_2 - 0.036 14.0 4.2 0.072 13.0 4.1 1.6 1 1 0 1 1 1 0 Adenomatous polyposis coli tumour suppressor protein Spc7 PF08317.9 MSTRG.13702.1_2 - 0.096 11.4 16.9 0.18 10.5 2.6 2.0 1 1 0 2 2 2 0 Spc7 kinetochore protein MCU PF04678.11 MSTRG.13702.1_2 - 0.14 12.2 2.7 0.22 11.5 2.7 1.4 1 0 0 1 1 1 0 Mitochondrial calcium uniporter UPF0693 PF16088.3 MSTRG.13702.1_2 - 0.17 12.0 4.0 2.6 8.2 4.0 2.4 1 1 0 1 1 1 0 UPF0693 family Exonuc_VII_L PF02601.13 MSTRG.13702.1_2 - 0.21 11.0 7.4 0.27 10.6 7.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Sec8_exocyst PF04048.12 MSTRG.13702.1_2 - 0.26 11.1 7.5 0.11 12.3 3.6 2.1 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain Peptidase_S46 PF10459.7 MSTRG.13702.1_2 - 0.26 9.7 5.7 0.33 9.4 5.7 1.1 1 0 0 1 1 1 0 Peptidase S46 APG6 PF04111.10 MSTRG.13702.1_2 - 0.39 9.9 14.3 0.6 9.3 14.3 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Mnd1 PF03962.13 MSTRG.13702.1_2 - 0.44 10.3 14.1 0.52 10.0 12.5 1.7 1 1 1 2 2 2 0 Mnd1 family COG2 PF06148.9 MSTRG.13702.1_2 - 0.51 10.3 8.5 0.24 11.4 0.9 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Herpes_UL14 PF03580.12 MSTRG.13702.1_2 - 0.78 9.9 8.5 1.3 9.1 8.5 1.2 1 0 0 1 1 1 0 Herpesvirus UL14-like protein DUF342 PF03961.11 MSTRG.13702.1_2 - 2.2 6.7 8.4 3 6.2 8.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF4407 PF14362.4 MSTRG.13702.1_2 - 2.3 7.4 9.6 17 4.5 9.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.17 MSTRG.13702.1_2 - 2.9 5.5 10.1 3.6 5.2 10.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1664 PF07889.10 MSTRG.13702.1_2 - 3.5 7.5 10.2 13 5.6 0.3 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) DASH_Spc34 PF08657.8 MSTRG.13702.1_2 - 4 7.1 14.6 0.43 10.3 1.1 2.1 1 1 1 2 2 2 0 DASH complex subunit Spc34 PCRF PF03462.16 MSTRG.13702.1_2 - 6.4 6.4 9.8 12 5.5 9.6 1.6 1 1 0 1 1 1 0 PCRF domain AATF-Che1 PF13339.4 MSTRG.13702.1_2 - 8.4 6.9 11.8 5.5 7.5 9.8 1.7 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor LMBR1 PF04791.14 MSTRG.13702.1_2 - 8.6 5.0 7.6 11 4.6 7.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4140 PF13600.4 MSTRG.13702.1_2 - 8.6 6.7 7.4 4.3e+02 1.3 7.4 2.4 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) DUF4782 PF16016.3 MSTRG.3629.3_2 - 7.5e-36 123.7 0.1 1.3e-35 123.0 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4782) GRAM PF02893.18 MSTRG.3629.3_2 - 2.7e-27 94.7 1.1 4e-27 94.2 0.2 1.8 2 0 0 2 2 2 1 GRAM domain MBT PF02820.16 MSTRG.24255.3_1 - 5.8e-15 55.3 0.0 9.3e-15 54.6 0.0 1.3 1 0 0 1 1 1 1 mbt repeat MBT PF02820.16 MSTRG.24255.3_2 - 3.2e-36 123.4 0.1 8.6e-17 61.1 0.0 2.4 2 0 0 2 2 2 2 mbt repeat SLED PF12140.6 MSTRG.24255.3_2 - 7.7e-36 122.9 0.1 1.2e-35 122.2 0.1 1.3 1 0 0 1 1 1 1 SLED domain zf-H2C2_2 PF13465.4 MSTRG.24255.3_2 - 2.4e-06 27.6 0.1 0.0075 16.6 0.0 3.5 3 1 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.24255.3_2 - 0.00021 21.4 4.8 0.00021 21.4 4.8 2.4 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.24255.3_2 - 0.0013 19.2 3.1 0.0013 19.2 3.1 3.2 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_11 PF16622.3 MSTRG.24255.3_2 - 0.065 12.9 4.2 0.16 11.6 4.2 1.7 1 0 0 1 1 1 0 zinc-finger C2H2-type zf-C2HC_2 PF13913.4 MSTRG.24255.3_2 - 5.6 6.9 10.1 0.14 11.9 2.0 2.6 2 0 0 2 2 2 0 zinc-finger of a C2HC-type MBT PF02820.16 MSTRG.24255.3_3 - 4.3e-22 78.1 0.0 6.9e-22 77.5 0.0 1.3 1 0 0 1 1 1 1 mbt repeat Rpn3_C PF08375.9 MSTRG.5315.1_2 - 9.9e-28 96.2 2.2 9.9e-28 96.2 2.2 1.9 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.25 MSTRG.5315.1_2 - 1e-23 83.7 0.0 2.7e-23 82.4 0.0 1.8 1 0 0 1 1 1 1 PCI domain TPR_2 PF07719.15 MSTRG.5315.1_2 - 0.091 12.8 0.7 0.56 10.3 0.3 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.5315.1_2 - 6.5 7.0 9.0 0.38 11.0 1.3 2.9 4 0 0 4 4 4 0 Tetratricopeptide repeat CN_hydrolase PF00795.20 MSTRG.16563.1_3 - 2.3e-60 204.0 0.0 2.9e-60 203.7 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Guanylate_kin PF00625.19 MSTRG.2738.4_2 - 3.3e-45 153.9 1.8 5e-45 153.3 1.8 1.2 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.22 MSTRG.18455.3_1 - 1.4e-33 115.0 5.5 3.7e-14 52.7 0.4 3.3 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.18455.3_1 - 2.1e-16 59.9 0.0 0.0001 22.4 0.0 3.3 3 0 0 3 3 3 3 PDZ domain MAGI_u5 PF16666.3 MSTRG.18455.3_1 - 2.4e-11 43.8 1.0 2.4e-11 43.8 1.0 2.9 2 1 1 3 3 3 1 Unstructured region on MAGI Tricorn_PDZ PF14685.4 MSTRG.18455.3_1 - 0.00091 19.1 0.2 0.67 9.9 0.0 3.3 3 0 0 3 3 3 2 Tricorn protease PDZ domain Acyltransferase PF01553.19 MSTRG.8315.1_1 - 1e-10 41.3 0.0 1.9e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Pyridoxal_deC PF00282.17 MSTRG.14729.2_3 - 1.8e-16 59.7 0.0 3e-16 59.0 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.17 MSTRG.14729.2_3 - 4.4e-09 35.6 0.0 7.5e-09 34.9 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.15 MSTRG.14729.2_3 - 0.00035 19.9 0.0 0.00049 19.4 0.0 1.1 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family EF-hand_7 PF13499.4 MSTRG.11167.1_3 - 6.2e-13 48.9 0.3 1.4e-09 38.2 0.1 1.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 MSTRG.11167.1_3 - 6.2e-12 44.0 0.6 2.1e-05 23.6 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.4 MSTRG.11167.1_3 - 3.1e-09 35.8 2.9 0.0012 18.2 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.4 MSTRG.11167.1_3 - 3.9e-09 35.6 0.6 0.0019 17.8 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.4 MSTRG.11167.1_3 - 8.5e-08 31.7 0.2 9e-06 25.2 0.1 2.5 1 1 1 2 2 2 2 EF-hand domain pair CARD PF00619.19 MSTRG.15582.2_2 - 1.4e-15 57.0 0.8 2.4e-15 56.2 0.8 1.4 1 0 0 1 1 1 1 Caspase recruitment domain CARD_2 PF16739.3 MSTRG.15582.2_2 - 0.0022 17.8 0.3 0.0035 17.2 0.3 1.4 1 0 0 1 1 1 1 Caspase recruitment domain DUF747 PF05346.9 MSTRG.17866.1_2 - 7.5e-50 170.1 7.2 1.1e-49 169.5 7.2 1.2 1 0 0 1 1 1 1 Eukaryotic membrane protein family Sugar_tr PF00083.22 MSTRG.23127.3_1 - 4.9e-30 104.7 0.9 4.9e-30 104.7 0.9 1.9 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.14 MSTRG.23127.3_1 - 1.5e-09 37.1 2.1 2.6e-09 36.4 2.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.22 MSTRG.23127.3_2 - 1.2e-35 123.1 17.9 6.1e-32 110.9 9.4 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter Sugar_tr PF00083.22 MSTRG.23127.3_3 - 0.00025 19.9 0.9 0.00041 19.2 0.9 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter DUF1899 PF08953.9 MSTRG.8697.4_3 - 9.1e-32 108.6 0.0 1.9e-31 107.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.3 MSTRG.8697.4_3 - 2.2e-21 75.3 0.5 6e-21 73.9 0.0 2.0 2 0 0 2 2 2 1 Type of WD40 repeat WD40 PF00400.30 MSTRG.8697.4_3 - 4.7e-14 52.4 9.2 2e-05 25.1 0.6 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.8697.4_3 - 3.3e-08 33.6 0.3 0.0029 17.7 0.0 2.8 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.3 MSTRG.8697.4_3 - 0.07 11.9 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain CH PF00307.29 MSTRG.11339.2_2 - 2.3e-14 53.4 0.0 3.6e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 MSTRG.11339.2_2 - 0.013 15.2 0.0 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 CAMSAP CH domain EF-hand_7 PF13499.4 MSTRG.2092.1_3 - 6.1e-05 23.3 1.2 0.00018 21.8 1.2 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.2092.1_3 - 0.00018 21.1 0.1 0.26 11.2 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.30 MSTRG.2092.1_3 - 0.0033 16.7 0.0 2.4 7.8 0.0 2.7 2 0 0 2 2 2 2 EF hand SspO PF08175.10 MSTRG.2092.1_3 - 0.7 10.3 4.9 1.7 9.1 4.9 1.6 1 0 0 1 1 1 0 Small acid-soluble spore protein O family Adeno_PV PF03910.11 MSTRG.29591.1_2 - 0.32 9.5 1.7 0.35 9.4 1.7 1.0 1 0 0 1 1 1 0 Adenovirus minor core protein PV SKG6 PF08693.8 MSTRG.17161.2_2 - 0.00012 21.2 0.1 0.00021 20.5 0.1 1.3 1 0 0 1 1 1 1 Transmembrane alpha-helix domain V-set PF07686.15 MSTRG.17161.2_3 - 0.00021 21.3 0.1 0.0004 20.4 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain IRS PF02174.15 MSTRG.18990.2_2 - 6.7e-08 32.2 0.0 1.4e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 PTB domain (IRS-1 type) PH PF00169.27 MSTRG.18990.2_2 - 0.043 14.2 0.0 0.13 12.7 0.0 1.7 1 0 0 1 1 1 0 PH domain GATA-N PF05349.10 MSTRG.8323.1_1 - 3.1e-49 167.6 24.6 3.1e-49 167.6 24.6 2.3 2 1 0 2 2 2 1 GATA-type transcription activator, N-terminal GATA PF00320.25 MSTRG.8323.1_1 - 2.3e-28 97.4 16.5 8.9e-15 53.9 5.4 2.6 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.10 MSTRG.8323.1_1 - 0.0025 17.1 17.2 0.011 15.1 1.0 3.2 3 0 0 3 3 3 2 TFIIB zinc-binding DUF659 PF04937.13 MSTRG.28015.1_2 - 0.00067 19.4 0.0 0.0012 18.6 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF 659) DDDD PF10161.7 MSTRG.28015.1_2 - 0.02 14.5 0.0 0.029 14.0 0.0 1.2 1 0 0 1 1 1 0 Putative mitochondrial precursor protein BRICHOS PF04089.12 MSTRG.27187.6_2 - 7.9e-21 73.8 0.0 1.6e-20 72.8 0.0 1.5 1 0 0 1 1 1 1 BRICHOS domain SRRM_C PF15230.4 MSTRG.27187.6_3 - 0.23 11.9 8.5 0.67 10.4 8.5 1.8 1 0 0 1 1 1 0 Serine/arginine repetitive matrix protein C-terminus TF_Otx PF03529.11 MSTRG.18298.1_3 - 1.4e-34 118.2 22.8 1.4e-34 118.2 22.8 3.7 3 2 1 4 4 4 1 Otx1 transcription factor Homeobox PF00046.27 MSTRG.18298.1_3 - 8.6e-22 76.6 2.2 1.4e-21 75.9 2.2 1.4 1 0 0 1 1 1 1 Homeobox domain Neisseria_TspB PF05616.11 MSTRG.18298.1_3 - 0.38 9.0 3.0 0.53 8.6 3.0 1.1 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein FAM199X PF15814.3 MSTRG.18298.1_3 - 0.52 9.2 5.1 0.88 8.4 5.1 1.4 1 0 0 1 1 1 0 Protein family FAM199X TPR_2 PF07719.15 MSTRG.14586.2_3 - 2e-10 39.8 26.7 0.003 17.4 0.7 7.6 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.14586.2_3 - 3.7e-10 39.1 12.6 0.016 15.3 0.0 6.8 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.14586.2_3 - 3e-08 33.3 4.3 0.0048 17.1 0.1 5.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.14586.2_3 - 7.9e-08 31.7 22.3 0.0066 16.1 0.1 7.3 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.14586.2_3 - 2.9e-07 30.6 4.6 0.37 11.6 0.1 6.6 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.14586.2_3 - 1.4e-06 28.6 8.6 0.00024 21.4 0.2 5.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_9 PF13371.4 MSTRG.14586.2_3 - 3e-06 27.2 0.8 0.00013 21.9 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.14586.2_3 - 6.2e-06 26.3 12.9 0.054 13.7 1.2 5.5 3 1 1 5 5 4 3 Tetratricopeptide repeat TPR_15 PF13429.4 MSTRG.14586.2_3 - 1.6e-05 24.1 3.0 0.22 10.6 0.4 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.14586.2_3 - 2.3e-05 24.9 4.6 0.00022 21.7 0.6 3.9 3 2 1 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.14586.2_3 - 0.00021 20.8 0.6 0.0094 15.5 0.3 3.3 3 1 0 3 3 3 1 TPR repeat ANAPC3 PF12895.5 MSTRG.14586.2_3 - 0.014 15.5 17.0 0.038 14.0 2.5 4.0 3 1 1 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.15 MSTRG.14586.2_3 - 0.046 14.0 2.9 0.39 11.0 0.2 3.1 3 1 1 4 4 3 0 Bacterial transcriptional activator domain TPR_6 PF13174.4 MSTRG.14586.2_3 - 0.24 12.0 5.9 5.8 7.6 0.0 5.3 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.14586.2_3 - 0.42 10.6 12.3 38 4.5 0.1 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.14586.2_3 - 3.9 7.3 10.5 14 5.6 0.5 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat LRR_8 PF13855.4 MSTRG.6467.1_3 - 1.3e-41 140.0 36.7 2.4e-15 55.9 8.0 5.9 2 2 4 6 6 6 5 Leucine rich repeat LRR_4 PF12799.5 MSTRG.6467.1_3 - 1.8e-16 59.8 38.2 0.00018 21.6 5.2 7.1 7 0 0 7 7 7 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 MSTRG.6467.1_3 - 3.1e-15 56.1 0.1 1.2e-07 31.5 0.0 2.6 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_9 PF14580.4 MSTRG.6467.1_3 - 4e-07 29.6 18.9 0.00037 19.9 4.7 4.1 2 2 3 5 5 5 5 Leucine-rich repeat TPKR_C2 PF16920.3 MSTRG.6467.1_3 - 0.00054 19.9 1.0 0.27 11.3 0.1 3.2 2 0 0 2 2 2 2 Tyrosine-protein kinase receptor C2 Ig-like domain Defensin_3 PF08131.9 MSTRG.23736.1_2 - 1.7 8.8 4.2 1.2 9.3 0.1 2.6 3 0 0 3 3 3 0 Defensin-like peptide family LAP1C PF05609.10 MSTRG.23736.1_3 - 1.5e-82 278.0 6.1 1.1e-81 275.1 6.0 1.9 1 1 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) TFIIF_beta PF02270.13 MSTRG.23736.1_3 - 0.031 14.3 5.9 0.058 13.4 5.9 1.4 1 0 0 1 1 1 0 Transcription initiation factor IIF, beta subunit Sushi PF00084.18 MSTRG.27385.1_1 - 3.7e-27 94.6 24.7 1.3e-09 38.4 4.5 3.7 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) Lectin_C PF00059.19 MSTRG.27385.1_1 - 1e-16 61.5 3.9 1e-16 61.5 3.9 2.7 3 1 1 4 4 4 1 Lectin C-type domain EGF PF00008.25 MSTRG.27385.1_1 - 0.00026 21.1 5.1 0.00026 21.1 5.1 3.7 3 1 1 4 4 4 1 EGF-like domain PAC1 PF16094.3 MSTRG.80.4_1 - 2.7e-124 413.8 0.5 3.1e-124 413.6 0.5 1.0 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 QLQ PF08880.9 MSTRG.4943.4_2 - 2.5e-14 52.6 4.7 4.4e-14 51.8 4.7 1.4 1 0 0 1 1 1 1 QLQ adh_short PF00106.23 MSTRG.18610.1_2 - 2.9e-36 124.6 0.0 3.9e-36 124.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 MSTRG.18610.1_2 - 1.6e-22 80.1 0.0 2.2e-22 79.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase zf-C2H2_jaz PF12171.6 MSTRG.2391.1_2 - 1.4e-06 28.3 16.7 0.0021 18.2 0.2 4.8 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.4 MSTRG.2391.1_2 - 0.00027 21.4 42.8 0.46 11.3 1.9 7.9 7 0 0 7 7 7 4 C2H2-type zinc finger zf-met PF12874.5 MSTRG.2391.1_2 - 0.23 11.8 21.4 3 8.2 0.7 4.7 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.24 MSTRG.2391.1_2 - 3.3 8.2 44.8 0.083 13.2 1.2 7.4 7 0 0 7 7 7 0 Zinc finger, C2H2 type Myelin_MBP PF01669.15 MSTRG.21400.4_3 - 1e-28 100.8 12.9 1.7e-22 80.5 6.9 2.2 1 1 1 2 2 2 2 Myelin basic protein PNRC PF15365.4 MSTRG.8241.1_1 - 1.1e-10 41.7 1.9 1.1e-10 41.7 1.9 2.5 2 0 0 2 2 2 1 Proline-rich nuclear receptor coactivator Hyr1 PF15789.3 MSTRG.15830.2_1 - 0.13 11.7 3.1 0.32 10.4 3.1 1.6 1 0 0 1 1 1 0 Hyphally regulated cell wall GPI-anchored protein 1 MFS_1 PF07690.14 MSTRG.15830.2_3 - 2.1e-23 82.7 43.6 2.8e-13 49.4 26.4 2.4 2 1 1 3 3 3 2 Major Facilitator Superfamily Sema PF01403.17 MSTRG.15108.1_2 - 4.3e-146 486.9 0.0 6.5e-146 486.3 0.0 1.3 1 0 0 1 1 1 1 Sema domain PSI PF01437.23 MSTRG.15108.1_2 - 9.9e-08 32.3 3.5 2.6e-07 30.9 3.5 1.8 1 0 0 1 1 1 1 Plexin repeat ig PF00047.23 MSTRG.15108.1_2 - 7.4e-06 25.9 0.0 4.5e-05 23.4 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 MSTRG.15108.1_2 - 1e-05 25.4 0.0 3e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.15108.1_2 - 2.5e-05 24.7 0.0 0.00018 21.9 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain PSI_integrin PF17205.1 MSTRG.15108.1_2 - 0.16 11.7 3.9 0.39 10.4 3.9 1.7 1 0 0 1 1 1 0 Integrin plexin domain EIF_2_alpha PF07541.10 MSTRG.25608.1_2 - 4.2e-36 123.4 0.0 7.2e-36 122.7 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.21 MSTRG.25608.1_2 - 4.7e-15 55.6 0.7 8.9e-15 54.7 0.7 1.4 1 0 0 1 1 1 1 S1 RNA binding domain zf-CXXC PF02008.18 MSTRG.6169.3_3 - 6.8e-13 48.3 21.9 1.7e-12 47.1 21.9 1.6 1 0 0 1 1 1 1 CXXC zinc finger domain Pkinase PF00069.23 MSTRG.25976.1_2 - 5e-69 232.5 0.0 7.2e-69 231.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.25976.1_2 - 9.3e-53 179.0 0.0 2.7e-52 177.5 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.25976.1_2 - 0.008 15.4 0.0 0.021 14.0 0.0 1.6 1 1 0 1 1 1 1 Kinase-like DUF1241 PF06840.9 MSTRG.25976.1_2 - 0.021 14.3 0.0 0.052 13.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1241) Pkinase_Tyr PF07714.15 MSTRG.9133.1_3 - 1.6e-92 309.4 0.0 2.8e-92 308.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Focal_AT PF03623.11 MSTRG.9133.1_3 - 1.1e-54 183.8 2.8 2.7e-54 182.5 2.8 1.7 1 0 0 1 1 1 1 Focal adhesion targeting region Pkinase PF00069.23 MSTRG.9133.1_3 - 1.1e-44 152.7 0.0 2.1e-44 151.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain FERM_M PF00373.16 MSTRG.9133.1_3 - 4.3e-10 39.9 0.4 1.4e-09 38.3 0.4 1.9 1 0 0 1 1 1 1 FERM central domain Kinase-like PF14531.4 MSTRG.9133.1_3 - 0.075 12.2 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Ribosomal_L7Ae PF01248.24 MSTRG.16454.2_1 - 5e-29 99.8 1.6 6.6e-29 99.4 1.6 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Guanylate_kin PF00625.19 MSTRG.10892.2_1 - 4.5e-49 166.5 0.2 6.6e-49 165.9 0.2 1.2 1 0 0 1 1 1 1 Guanylate kinase VGCC_beta4Aa_N PF12052.6 MSTRG.10892.2_1 - 3.2e-19 68.6 4.0 5.1e-19 68.0 2.7 2.0 2 0 0 2 2 2 1 Voltage gated calcium channel subunit beta domain 4Aa N terminal SH3_1 PF00018.26 MSTRG.10892.2_1 - 0.0023 17.4 1.4 0.0038 16.7 0.1 2.1 3 0 0 3 3 3 1 SH3 domain SH3_9 PF14604.4 MSTRG.10892.2_1 - 0.035 13.8 0.0 0.068 12.9 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain SH3_2 PF07653.15 MSTRG.10892.2_1 - 0.045 13.3 0.0 0.045 13.3 0.0 1.8 2 0 0 2 2 2 0 Variant SH3 domain EGF PF00008.25 MSTRG.29034.1_3 - 6e-08 32.7 23.8 0.00076 19.6 7.2 2.7 2 1 0 2 2 2 2 EGF-like domain FXa_inhibition PF14670.4 MSTRG.29034.1_3 - 3.8e-07 30.1 7.0 3.8e-07 30.1 7.0 2.5 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site hEGF PF12661.5 MSTRG.29034.1_3 - 0.00041 20.8 19.8 0.0037 17.7 5.1 3.7 3 1 0 3 3 3 2 Human growth factor-like EGF EGF_2 PF07974.11 MSTRG.29034.1_3 - 0.015 15.5 9.6 0.015 15.5 9.6 3.2 3 1 0 3 3 3 0 EGF-like domain fn3 PF00041.19 MSTRG.2304.1_1 - 3.8e-24 84.7 16.9 9.2e-07 29.0 0.2 5.4 5 0 0 5 5 5 4 Fibronectin type III domain Lep_receptor_Ig PF06328.9 MSTRG.2304.1_1 - 1.2e-10 41.1 1.1 1.2e-10 41.1 1.1 2.8 2 0 0 2 2 2 1 Ig-like C2-type domain Pur_ac_phosph_N PF16656.3 MSTRG.2304.1_1 - 0.013 15.9 9.8 0.1 13.0 0.1 3.5 2 1 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.3 MSTRG.2304.1_1 - 0.077 13.0 1.0 1.1 9.3 0.1 2.9 3 0 0 3 3 3 0 Fibronectin type III domain Bcr-Abl_Oligo PF09036.8 MSTRG.24405.6_2 - 0.19 11.6 0.3 19 5.2 0.0 2.2 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain VWA PF00092.26 MSTRG.24405.6_3 - 3.8e-63 212.8 1.2 5e-47 160.3 0.0 2.0 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.4 MSTRG.24405.6_3 - 3.8e-24 85.3 0.0 2.4e-16 60.2 0.0 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain SRPRB PF09439.8 MSTRG.24405.6_3 - 8.6e-06 25.2 0.0 0.072 12.4 0.0 2.2 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit VWA_3 PF13768.4 MSTRG.24405.6_3 - 2.4e-05 24.1 0.0 0.0082 15.9 0.0 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_CoxE PF05762.12 MSTRG.24405.6_3 - 0.014 14.7 1.1 2.2 7.5 0.1 3.0 2 1 0 2 2 2 0 VWA domain containing CoxE-like protein DUF2201 PF09967.7 MSTRG.24405.6_3 - 0.03 14.3 0.1 36 4.4 0.0 3.2 3 0 0 3 3 3 0 VWA-like domain (DUF2201) SUKH_5 PF14567.4 MSTRG.24405.6_3 - 0.1 12.2 0.0 1.8 8.2 0.0 2.4 3 0 0 3 3 3 0 SMI1-KNR4 cell-wall DARPP-32 PF05395.10 MSTRG.26959.1_1 - 2.6e-26 92.6 2.5 3.2e-26 92.3 2.5 1.1 1 0 0 1 1 1 1 Protein phosphatase inhibitor 1/DARPP-32 PHD PF00628.27 MSTRG.7683.2_1 - 2.2e-06 27.3 15.4 5.4e-06 26.1 15.4 1.6 1 0 0 1 1 1 1 PHD-finger Snf7 PF03357.19 MSTRG.5225.4_3 - 1.3e-50 171.3 13.4 1.6e-50 170.9 13.4 1.1 1 0 0 1 1 1 1 Snf7 DUF155 PF02582.12 MSTRG.5225.4_3 - 0.044 13.7 2.4 0.065 13.2 2.4 1.2 1 0 0 1 1 1 0 Uncharacterised ACR, YagE family COG1723 Kinesin_assoc PF16183.3 MSTRG.5225.4_3 - 1.3 9.0 6.4 0.29 11.1 0.3 2.1 1 1 1 2 2 2 0 Kinesin-associated DUF4407 PF14362.4 MSTRG.5225.4_3 - 8.2 5.5 7.6 12 5.0 7.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.17 MSTRG.5225.4_3 - 9.2 3.9 9.7 12 3.4 9.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family zf-H2C2_2 PF13465.4 MSTRG.28509.1_2 - 9.1e-37 123.8 34.5 2e-09 37.3 0.4 5.0 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.28509.1_2 - 5.6e-25 86.2 40.5 2.7e-07 30.5 0.4 4.8 5 0 0 5 5 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.28509.1_2 - 2.6e-20 71.2 34.7 7.5e-06 26.2 1.4 4.4 5 0 0 5 5 4 4 C2H2-type zinc finger zf-met PF12874.5 MSTRG.28509.1_2 - 1.6e-14 53.6 24.1 0.00018 21.7 1.9 4.3 4 0 0 4 4 4 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.28509.1_2 - 1.7e-13 50.3 8.1 0.0011 19.1 0.4 4.2 4 0 0 4 4 4 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 MSTRG.28509.1_2 - 7.7e-13 47.9 26.1 0.00036 20.3 1.1 4.8 5 0 0 5 5 4 4 C2H2-type zinc finger LIM PF00412.20 MSTRG.28509.1_2 - 4.4e-07 29.9 10.2 0.0073 16.4 2.2 4.0 2 1 2 4 4 4 2 LIM domain zf-Di19 PF05605.10 MSTRG.28509.1_2 - 8.5e-06 25.8 11.8 0.0019 18.3 2.8 2.5 1 1 2 3 3 3 3 Drought induced 19 protein (Di19), zinc-binding zf-LYAR PF08790.9 MSTRG.28509.1_2 - 8.7e-06 25.4 18.0 0.083 12.7 0.1 4.4 4 0 0 4 4 4 2 LYAR-type C2HC zinc finger zf-C2H2_11 PF16622.3 MSTRG.28509.1_2 - 1.6e-05 24.4 15.2 0.0063 16.1 1.7 4.2 4 0 0 4 4 4 1 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 MSTRG.28509.1_2 - 9e-05 22.4 11.8 0.39 10.7 2.8 4.0 3 1 1 4 4 4 2 Zinc ribbon domain zinc_ribbon_15 PF17032.3 MSTRG.28509.1_2 - 0.00014 22.5 4.3 0.12 13.0 0.3 2.2 1 1 0 2 2 2 2 zinc-ribbon family FYDLN_acid PF09538.8 MSTRG.28509.1_2 - 0.00021 21.8 4.8 4 8.0 0.0 3.9 1 1 3 4 4 4 0 Protein of unknown function (FYDLN_acid) zf-C2HE PF16278.3 MSTRG.28509.1_2 - 0.00086 19.6 20.0 2.1 8.8 0.5 4.2 1 1 3 4 4 4 1 C2HE / C2H2 / C2HC zinc-binding finger DZR PF12773.5 MSTRG.28509.1_2 - 0.0012 18.6 8.2 0.85 9.6 8.2 2.4 1 1 0 1 1 1 1 Double zinc ribbon YhfH PF14149.4 MSTRG.28509.1_2 - 0.0015 18.3 2.3 10 6.1 0.0 3.3 3 0 0 3 3 3 0 YhfH-like protein Chordopox_RPO7 PF05864.10 MSTRG.28509.1_2 - 0.002 18.2 3.2 2.3 8.4 0.1 3.6 4 0 0 4 4 3 1 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) zf-C2H2_2 PF12756.5 MSTRG.28509.1_2 - 0.0029 17.8 12.4 2 8.7 0.1 3.9 1 1 3 4 4 4 1 C2H2 type zinc-finger (2 copies) CpXC PF14353.4 MSTRG.28509.1_2 - 0.0032 17.4 8.6 4.2 7.3 0.1 3.9 2 2 2 4 4 4 0 CpXC protein zf-AN1 PF01428.14 MSTRG.28509.1_2 - 0.0037 17.3 20.3 4.1 7.5 1.0 4.3 2 1 2 4 4 4 0 AN1-like Zinc finger Prok-RING_1 PF14446.4 MSTRG.28509.1_2 - 0.0061 16.3 6.1 3.2 7.6 0.0 4.0 4 0 0 4 4 4 0 Prokaryotic RING finger family 1 zf-trcl PF13451.4 MSTRG.28509.1_2 - 0.0071 16.1 12.0 1 9.2 0.3 3.9 3 1 0 3 3 3 1 Probable zinc-ribbon domain DUF2256 PF10013.7 MSTRG.28509.1_2 - 0.0071 16.3 8.3 3.9 7.5 0.1 4.1 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-DNA_Pol PF08996.8 MSTRG.28509.1_2 - 0.0079 15.8 6.2 0.34 10.5 0.5 2.0 1 1 1 2 2 2 2 DNA Polymerase alpha zinc finger MBD PF01429.17 MSTRG.28509.1_2 - 0.011 15.3 0.1 0.61 9.7 0.1 2.3 1 1 0 1 1 1 0 Methyl-CpG binding domain DUF4428 PF14471.4 MSTRG.28509.1_2 - 0.015 15.1 8.8 0.64 9.8 1.9 3.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4428) Elf1 PF05129.11 MSTRG.28509.1_2 - 0.017 15.0 9.7 0.17 11.8 1.5 2.8 1 1 2 3 3 3 0 Transcription elongation factor Elf1 like HypA PF01155.17 MSTRG.28509.1_2 - 0.019 14.9 6.6 1.5 8.7 0.6 2.8 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TFIIS_C PF01096.16 MSTRG.28509.1_2 - 0.019 14.7 9.3 4.5 7.1 0.1 4.0 4 0 0 4 4 4 0 Transcription factor S-II (TFIIS) TF_Zn_Ribbon PF08271.10 MSTRG.28509.1_2 - 0.033 13.6 10.4 0.26 10.7 2.0 3.4 3 1 0 3 3 2 0 TFIIB zinc-binding DUF3268 PF11672.6 MSTRG.28509.1_2 - 0.034 14.4 3.1 0.29 11.3 0.3 2.4 1 1 2 3 3 3 0 zinc-finger-containing domain Zn_ribbon_recom PF13408.4 MSTRG.28509.1_2 - 0.034 14.5 13.5 1.8 9.0 0.8 3.4 1 1 2 3 3 3 0 Recombinase zinc beta ribbon domain HNH_5 PF14279.4 MSTRG.28509.1_2 - 0.059 13.1 7.4 5 6.9 0.3 4.0 2 1 1 3 3 3 0 HNH endonuclease DUF2197 PF09963.7 MSTRG.28509.1_2 - 0.065 13.4 11.3 4.4 7.5 0.4 3.9 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2197) zf-piccolo PF05715.11 MSTRG.28509.1_2 - 0.094 12.7 8.0 0.12 12.4 0.7 2.9 1 1 2 3 3 3 0 Piccolo Zn-finger zf-ribbon_3 PF13248.4 MSTRG.28509.1_2 - 0.095 12.0 8.7 4.5 6.7 0.2 3.6 4 0 0 4 4 4 0 zinc-ribbon domain XPA_N PF01286.16 MSTRG.28509.1_2 - 0.11 12.4 13.4 10 6.1 0.3 4.1 4 0 0 4 4 4 0 XPA protein N-terminal zf-C2H2_9 PF16293.3 MSTRG.28509.1_2 - 0.14 11.9 3.6 8.7 6.1 0.0 3.6 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-ISL3 PF14690.4 MSTRG.28509.1_2 - 0.14 12.7 13.8 1.7 9.1 0.4 4.2 4 0 0 4 4 4 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zinc_ribbon_2 PF13240.4 MSTRG.28509.1_2 - 0.15 11.7 9.0 8.3 6.1 0.1 3.5 3 0 0 3 3 3 0 zinc-ribbon domain ADK_lid PF05191.12 MSTRG.28509.1_2 - 0.2 11.6 9.5 0.63 10.0 2.2 2.9 1 1 2 3 3 3 0 Adenylate kinase, active site lid zinc_ribbon_9 PF14369.4 MSTRG.28509.1_2 - 0.28 11.3 10.2 12 6.2 0.3 4.0 4 0 0 4 4 4 0 zinc-ribbon DUF1163 PF06651.9 MSTRG.28509.1_2 - 0.29 11.1 2.8 1.4 9.0 0.8 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1163) Lar_restr_allev PF14354.4 MSTRG.28509.1_2 - 0.3 11.3 6.0 2.9 8.2 3.2 2.6 1 1 0 1 1 1 0 Restriction alleviation protein Lar Zn_Tnp_IS1595 PF12760.5 MSTRG.28509.1_2 - 0.38 10.7 17.9 0.93 9.4 4.7 3.2 1 1 2 3 3 3 0 Transposase zinc-ribbon domain zf-RING_5 PF14634.4 MSTRG.28509.1_2 - 0.42 10.5 10.3 18 5.3 0.1 3.5 1 1 2 3 3 3 0 zinc-RING finger domain Rad50_zn_hook PF04423.12 MSTRG.28509.1_2 - 0.45 10.3 0.2 0.45 10.3 0.2 2.2 3 0 0 3 3 1 0 Rad50 zinc hook motif PhnA_Zn_Ribbon PF08274.10 MSTRG.28509.1_2 - 0.48 10.3 5.4 23 4.9 0.0 3.5 4 0 0 4 4 3 0 PhnA Zinc-Ribbon C1_4 PF07975.10 MSTRG.28509.1_2 - 0.79 9.9 9.6 0.35 11.0 0.9 3.0 1 1 3 4 4 4 0 TFIIH C1-like domain zinc_ribbon_6 PF14599.4 MSTRG.28509.1_2 - 1.2 9.1 7.3 2.6 8.0 0.2 2.8 2 1 1 3 3 2 0 Zinc-ribbon zf-BED PF02892.13 MSTRG.28509.1_2 - 1.3 9.0 23.1 4.7 7.2 0.9 4.2 1 1 3 4 4 4 0 BED zinc finger DNA_RNApol_7kD PF03604.11 MSTRG.28509.1_2 - 1.5 8.4 6.2 17 5.1 0.1 3.5 4 0 0 4 4 4 0 DNA directed RNA polymerase, 7 kDa subunit PknG_rubred PF16919.3 MSTRG.28509.1_2 - 1.5 8.8 10.4 1.6 8.7 2.1 2.9 1 1 3 4 4 4 0 Protein kinase G rubredoxin domain GATA PF00320.25 MSTRG.28509.1_2 - 1.5 8.3 8.7 0.28 10.7 1.1 3.0 3 1 1 4 4 3 0 GATA zinc finger IBR PF01485.19 MSTRG.28509.1_2 - 1.7 8.8 12.2 1.2e+02 2.9 2.3 3.0 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain PHD PF00628.27 MSTRG.28509.1_2 - 1.8 8.4 9.2 3.9 7.3 1.0 3.1 1 1 2 3 3 3 0 PHD-finger Prim_Zn_Ribbon PF08273.10 MSTRG.28509.1_2 - 2.3 8.5 9.8 2.3 8.5 0.3 3.6 4 0 0 4 4 4 0 Zinc-binding domain of primase-helicase Nudix_N_2 PF14803.4 MSTRG.28509.1_2 - 2.8 7.8 10.6 34 4.3 3.5 3.6 2 1 1 3 3 3 0 Nudix N-terminal zinc_ribbon_4 PF13717.4 MSTRG.28509.1_2 - 2.9 7.8 12.0 33 4.4 0.1 4.0 3 1 1 4 4 4 0 zinc-ribbon domain Sgf11 PF08209.9 MSTRG.28509.1_2 - 3 7.4 11.3 20 4.7 0.1 4.1 4 0 0 4 4 4 0 Sgf11 (transcriptional regulation protein) zf-RVT PF13966.4 MSTRG.28509.1_2 - 3.4 8.4 7.3 2.3 9.0 0.8 2.9 1 1 3 4 4 4 0 zinc-binding in reverse transcriptase Prok-RING_4 PF14447.4 MSTRG.28509.1_2 - 3.5 7.4 9.8 3.5 7.4 0.1 3.6 3 1 0 3 3 3 0 Prokaryotic RING finger family 4 zf-HYPF PF07503.10 MSTRG.28509.1_2 - 3.5 7.3 12.9 3.7 7.3 2.9 3.5 3 1 1 4 4 4 0 HypF finger Vps39_2 PF10367.7 MSTRG.28509.1_2 - 3.7 7.9 10.8 26 5.2 0.1 3.9 1 1 2 4 4 4 0 Vacuolar sorting protein 39 domain 2 HNH PF01844.21 MSTRG.28509.1_2 - 4 7.6 15.2 17 5.6 0.3 4.1 4 0 0 4 4 4 0 HNH endonuclease OrfB_Zn_ribbon PF07282.9 MSTRG.28509.1_2 - 5.8 6.8 13.7 5.6 6.8 2.3 3.4 1 1 4 5 5 5 0 Putative transposase DNA-binding domain DUF983 PF06170.10 MSTRG.28509.1_2 - 9.9 6.5 7.4 65 3.9 0.1 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF983) RRM_1 PF00076.20 MSTRG.8609.3_3 - 3.1e-15 55.6 0.0 5.1e-15 54.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SET_assoc PF11767.6 MSTRG.8609.3_3 - 0.11 12.0 0.0 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated RRM_5 PF13893.4 MSTRG.8609.3_3 - 0.12 11.9 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Prefoldin_2 PF01920.18 MSTRG.25850.2_3 - 2.5e-24 85.1 2.7 3.4e-24 84.7 2.7 1.2 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.15 MSTRG.25850.2_3 - 0.034 13.9 0.9 0.081 12.7 0.9 1.6 1 1 0 1 1 1 0 Prefoldin subunit DegS PF05384.9 MSTRG.25850.2_3 - 0.11 11.9 2.5 0.15 11.4 0.6 1.9 2 0 0 2 2 2 0 Sensor protein DegS DUF148 PF02520.15 MSTRG.25850.2_3 - 0.36 10.8 2.5 0.23 11.4 0.4 1.7 2 0 0 2 2 2 0 Domain of unknown function DUF148 CFIA_Pcf11 PF11526.6 MSTRG.3915.8_2 - 1.8e-05 25.0 1.0 3.7e-05 24.0 1.0 1.5 1 0 0 1 1 1 1 Subunit of cleavage factor IA Pcf11 JmjC PF02373.20 MSTRG.10334.3_1 - 4.2e-14 52.8 0.0 9.4e-14 51.7 0.0 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase C1_2 PF03107.14 MSTRG.10334.3_1 - 0.13 12.4 4.9 0.54 10.5 4.9 2.1 1 0 0 1 1 1 0 C1 domain Ion_trans PF00520.29 MSTRG.9341.1_3 - 2.3e-97 324.9 39.2 1.7e-51 174.7 14.9 2.0 2 0 0 2 2 2 2 Ion transport protein HemY_N PF07219.11 MSTRG.9341.1_3 - 0.32 11.1 0.1 0.32 11.1 0.1 2.9 3 0 0 3 3 3 0 HemY protein N-terminus PDZ PF00595.22 MSTRG.25996.1_1 - 5.5e-10 39.3 0.0 1.4e-09 38.0 0.0 1.7 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Pkinase PF00069.23 MSTRG.25996.1_1 - 6.8e-09 35.3 0.0 9.9e-09 34.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain PDZ_2 PF13180.4 MSTRG.25996.1_1 - 4.3e-07 30.0 0.1 1.1e-06 28.7 0.1 1.6 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.4 MSTRG.25996.1_1 - 0.054 13.4 0.1 0.13 12.2 0.1 1.6 1 0 0 1 1 1 0 Tricorn protease PDZ domain Pkinase_C PF00433.22 MSTRG.25996.1_1 - 0.42 11.2 2.9 0.68 10.5 0.3 2.8 2 1 0 2 2 2 0 Protein kinase C terminal domain P34-Arc PF04045.12 MSTRG.20162.2_1 - 2.3e-103 345.0 0.6 2.9e-103 344.6 0.6 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc ARPC4 PF05856.10 MSTRG.20162.2_1 - 0.074 12.5 0.0 0.17 11.3 0.0 1.6 1 0 0 1 1 1 0 ARP2/3 complex 20 kDa subunit (ARPC4) Vps4_C PF09336.8 MSTRG.20162.2_1 - 0.1 12.5 0.1 2.3 8.1 0.0 2.8 3 0 0 3 3 3 0 Vps4 C terminal oligomerisation domain Cast PF10174.7 MSTRG.18432.2_2 - 2.5e-101 340.1 79.5 3.6e-100 336.2 74.3 2.5 2 1 0 2 2 2 1 RIM-binding protein of the cytomatrix active zone RBD-FIP PF09457.8 MSTRG.18432.2_2 - 1.8e-07 30.8 1.2 1.8e-07 30.8 1.2 3.7 4 0 0 4 4 4 1 FIP domain DUF1481 PF07356.10 MSTRG.18432.2_2 - 0.0061 16.2 0.5 0.0061 16.2 0.5 2.8 1 1 1 2 2 2 1 Protein of unknown function (DUF1481) zf-C2H2 PF00096.24 MSTRG.11742.1_2 - 1.4e-06 28.3 10.5 0.5 10.8 0.0 4.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.11742.1_2 - 0.00057 20.1 0.0 0.00057 20.1 0.0 2.3 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.11742.1_2 - 0.00064 20.2 14.6 0.25 12.1 0.0 4.5 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_11 PF16622.3 MSTRG.11742.1_2 - 0.2 11.3 10.2 1.7 8.3 0.0 3.6 3 0 0 3 3 3 0 zinc-finger C2H2-type MPDZ_u10 PF16667.3 MSTRG.11742.1_2 - 1.7 9.4 4.9 0.6 10.9 1.1 2.2 2 0 0 2 2 2 0 Unstructured region 10 on multiple PDZ protein FOXP-CC PF16159.3 MSTRG.11742.1_2 - 8.1 7.0 10.5 2.5 8.7 1.7 3.4 2 1 1 3 3 3 0 FOXP coiled-coil domain BicD PF09730.7 MSTRG.28684.1_1 - 1.8e-31 109.2 16.4 2e-31 109.1 16.4 1.0 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D ERM PF00769.17 MSTRG.28684.1_1 - 0.031 13.9 22.7 0.035 13.8 22.7 1.0 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Fez1 PF06818.13 MSTRG.28684.1_1 - 0.069 13.5 16.2 0.08 13.2 16.2 1.1 1 0 0 1 1 1 0 Fez1 DUF4559 PF15112.4 MSTRG.28684.1_1 - 0.12 11.9 6.5 0.17 11.4 6.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4559) DASH_Spc19 PF08287.9 MSTRG.28684.1_1 - 0.12 12.1 16.3 2.1 8.1 11.1 2.3 1 1 1 2 2 2 0 Spc19 DUF3847 PF12958.5 MSTRG.28684.1_1 - 0.19 11.8 11.5 1.5 8.9 3.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) CENP-F_leu_zip PF10473.7 MSTRG.28684.1_1 - 0.2 11.6 17.0 1.2 9.0 1.3 2.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Uso1_p115_C PF04871.11 MSTRG.28684.1_1 - 0.25 11.6 20.5 0.82 9.9 2.4 2.3 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region IncA PF04156.12 MSTRG.28684.1_1 - 0.41 10.3 19.7 1.5 8.5 19.7 1.7 1 1 0 1 1 1 0 IncA protein Fib_alpha PF08702.8 MSTRG.28684.1_1 - 0.48 10.5 10.0 3 7.9 0.3 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.9 MSTRG.28684.1_1 - 0.5 10.7 6.3 4.3 7.7 0.1 2.7 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Med9 PF07544.11 MSTRG.28684.1_1 - 1 9.4 10.1 3.5 7.6 5.4 2.2 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 PIEZO PF15917.3 MSTRG.28684.1_1 - 1.2 8.4 8.8 1.8 7.8 8.8 1.4 1 1 0 1 1 1 0 Piezo DUF1664 PF07889.10 MSTRG.28684.1_1 - 1.2 9.0 7.4 1.3 8.8 3.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Nup54 PF13874.4 MSTRG.28684.1_1 - 1.3 9.0 12.3 1.5 8.8 4.6 2.1 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Sulfatase_C PF14707.4 MSTRG.28684.1_1 - 1.3 9.6 5.3 7.8 7.1 0.9 2.0 1 1 1 2 2 2 0 C-terminal region of aryl-sulfatase Golgin_A5 PF09787.7 MSTRG.28684.1_1 - 1.3 8.2 17.5 2 7.7 17.5 1.3 1 1 0 1 1 1 0 Golgin subfamily A member 5 SlyX PF04102.10 MSTRG.28684.1_1 - 2.2 8.8 12.1 0.51 10.9 5.6 2.1 2 0 0 2 2 2 0 SlyX ZapB PF06005.10 MSTRG.28684.1_1 - 3.1 8.2 16.8 8.2 6.8 6.4 2.6 2 1 0 2 2 2 0 Cell division protein ZapB DUF4140 PF13600.4 MSTRG.28684.1_1 - 3.7 7.9 10.7 7.5e+02 0.5 10.7 2.3 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) AATF-Che1 PF13339.4 MSTRG.28684.1_1 - 3.8 8.1 12.6 4.5 7.8 0.7 2.1 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor ADIP PF11559.6 MSTRG.28684.1_1 - 5 7.1 16.6 3.9 7.4 10.4 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4407 PF14362.4 MSTRG.28684.1_1 - 5.6 6.1 12.7 3 7.0 9.5 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.13 MSTRG.28684.1_1 - 6 6.2 10.8 7.3 5.9 10.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit HR1 PF02185.14 MSTRG.28684.1_1 - 6.6 6.8 19.0 2.3 8.3 1.8 3.4 2 2 2 4 4 4 0 Hr1 repeat Connexin PF00029.17 MSTRG.15034.1_3 - 1.6e-93 312.5 7.3 2e-93 312.2 7.3 1.1 1 0 0 1 1 1 1 Connexin GTPase_binding PF09027.8 MSTRG.16281.1_2 - 3e-33 113.5 0.9 8.1e-33 112.1 0.9 1.8 1 0 0 1 1 1 1 GTPase binding UBA_4 PF14555.4 MSTRG.16281.1_2 - 1.2e-06 28.1 0.1 0.017 14.8 0.0 2.6 2 0 0 2 2 2 2 UBA-like domain SH3_9 PF14604.4 MSTRG.16281.1_2 - 8e-06 25.5 0.0 1.5e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.16281.1_2 - 4.7e-05 22.8 0.0 8.2e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.16281.1_2 - 0.019 14.5 0.0 0.036 13.6 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain HOIP-UBA PF16678.3 MSTRG.16281.1_2 - 0.033 14.1 0.3 0.07 13.0 0.3 1.5 1 0 0 1 1 1 0 UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase Pkinase_Tyr PF07714.15 MSTRG.16281.1_3 - 6.5e-27 94.3 0.0 8.2e-27 94.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.16281.1_3 - 2.1e-06 27.2 0.0 2.8e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain DUF1041 PF06292.15 MSTRG.23625.1_3 - 6.7e-37 125.9 0.1 9.5e-37 125.4 0.1 1.2 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1041) DUF2407_C PF13373.4 MSTRG.18922.3_1 - 0.13 12.4 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 DUF2407 C-terminal domain Xlink PF00193.15 MSTRG.9810.1_1 - 1.2e-20 73.5 0.1 1.8e-20 73.0 0.1 1.3 1 0 0 1 1 1 1 Extracellular link domain UCR_hinge PF02320.14 MSTRG.23742.1_2 - 6.1e-22 77.5 8.3 9.4e-22 76.9 8.3 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein dNK PF01712.17 MSTRG.23742.1_2 - 0.1 12.3 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Deoxynucleoside kinase WH2 PF02205.18 MSTRG.13368.4_3 - 5.4e-11 41.8 3.8 0.006 16.3 0.3 3.6 3 0 0 3 3 3 3 WH2 motif Spermine_synth PF01564.15 MSTRG.13368.4_3 - 0.12 11.1 0.0 0.29 9.9 0.0 1.5 2 0 0 2 2 2 0 Spermine/spermidine synthase Metallothio_PEC PF02068.14 MSTRG.13368.4_3 - 1.3 9.3 4.8 3.8 7.8 0.4 3.2 3 0 0 3 3 3 0 Plant PEC family metallothionein TPT PF03151.14 MSTRG.542.1_2 - 7.9e-21 74.5 13.4 1.1e-20 74.1 13.4 1.2 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.18 MSTRG.542.1_2 - 4.7e-05 23.4 10.3 4.7e-05 23.4 10.3 2.8 3 0 0 3 3 3 1 EamA-like transporter family SNARE PF05739.17 MSTRG.3397.1_3 - 1.3e-18 66.6 0.5 2.8e-18 65.5 0.5 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin-5_N PF11416.6 MSTRG.3397.1_3 - 7.3e-09 34.5 3.1 8.7e-09 34.2 1.3 2.2 2 0 0 2 2 2 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin PF00804.23 MSTRG.3397.1_3 - 0.00057 19.5 10.0 0.0049 16.4 10.0 2.1 1 1 0 1 1 1 1 Syntaxin Use1 PF09753.7 MSTRG.3397.1_3 - 0.00075 19.1 5.6 0.0011 18.5 5.6 1.2 1 0 0 1 1 1 1 Membrane fusion protein Use1 HrpB7 PF09486.8 MSTRG.3397.1_3 - 0.018 15.3 0.8 0.047 13.9 0.8 1.7 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) SEO_N PF14576.4 MSTRG.3397.1_3 - 0.045 12.8 4.2 0.19 10.7 0.2 2.3 2 1 0 2 2 2 0 Sieve element occlusion N-terminus SKA1 PF07160.10 MSTRG.3397.1_3 - 0.19 11.4 9.8 0.18 11.5 1.3 2.2 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 DUF16 PF01519.14 MSTRG.3397.1_3 - 0.21 12.0 8.5 0.064 13.6 2.2 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 Apolipoprotein PF01442.16 MSTRG.3397.1_3 - 0.26 11.1 6.7 3.3 7.4 6.7 2.1 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain MCPsignal PF00015.19 MSTRG.3397.1_3 - 0.85 9.2 5.7 0.17 11.5 1.5 1.8 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain BLOC1_2 PF10046.7 MSTRG.3397.1_3 - 1.2 9.4 7.4 2.1 8.6 1.1 3.2 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spectrin PF00435.19 MSTRG.3397.1_3 - 2.4 8.6 6.3 3.5 8.0 0.3 2.9 3 1 0 3 3 3 0 Spectrin repeat DUF1664 PF07889.10 MSTRG.3397.1_3 - 2.7 7.9 10.1 1.2 9.0 1.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Reo_sigmaC PF04582.10 MSTRG.3397.1_3 - 7.8 5.7 9.9 13 5.0 2.2 2.4 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Peptidase_C1 PF00112.21 MSTRG.4951.1_2 - 3.5e-87 292.0 1.3 3.5e-87 292.0 1.3 1.5 2 0 0 2 2 2 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 MSTRG.4951.1_2 - 4.3e-12 46.1 1.1 6.9e-12 45.5 1.1 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 MSTRG.4951.1_2 - 4.8e-05 22.2 2.0 0.0045 15.7 0.9 2.1 2 0 0 2 2 2 2 Peptidase C1-like family zf-H2C2_5 PF13909.4 MSTRG.2069.2_1 - 8.5e-07 28.5 3.5 3.2e-05 23.5 0.2 7.4 8 0 0 8 8 8 5 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 MSTRG.2069.2_1 - 0.0052 17.1 0.8 0.0052 17.1 0.8 8.7 9 0 0 9 9 9 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.2069.2_1 - 0.0057 16.9 1.7 0.0057 16.9 1.7 8.2 8 0 0 8 8 8 4 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.2069.2_1 - 0.0085 16.7 0.7 0.0085 16.7 0.7 8.4 9 0 0 9 9 9 3 C2H2-type zinc finger SDA1 PF05285.10 MSTRG.2069.2_1 - 0.24 10.7 20.7 0.4 10.0 20.7 1.3 1 0 0 1 1 1 0 SDA1 SH3_1 PF00018.26 MSTRG.69.1_3 - 5.2e-25 86.7 0.4 6.3e-13 48.0 0.0 2.4 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.4 MSTRG.69.1_3 - 9.2e-23 79.7 0.1 3.2e-11 42.7 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.15 MSTRG.69.1_3 - 4.4e-22 77.4 0.2 7.8e-12 44.6 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain NECFESHC PF16621.3 MSTRG.69.1_3 - 4e-21 74.6 6.6 1.1e-20 73.2 6.6 1.8 1 0 0 1 1 1 1 SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1 p47_phox_C PF08944.9 MSTRG.69.1_3 - 2.4e-15 55.5 5.2 8e-15 53.8 5.2 1.9 1 0 0 1 1 1 1 NADPH oxidase subunit p47Phox, C terminal domain PX PF00787.22 MSTRG.69.1_3 - 1.5e-12 47.4 0.9 3.4e-12 46.2 0.9 1.6 1 0 0 1 1 1 1 PX domain hSH3 PF14603.4 MSTRG.69.1_3 - 0.0018 18.7 0.0 0.086 13.3 0.0 2.4 1 1 1 2 2 2 1 Helically-extended SH3 domain SH3_6 PF12913.5 MSTRG.69.1_3 - 0.17 11.3 0.1 0.96 8.9 0.0 2.2 2 0 0 2 2 2 0 SH3 domain (SH3b1 type) PAP2 PF01569.19 MSTRG.23778.1_3 - 9.7e-17 60.9 4.6 1.8e-16 60.1 4.6 1.4 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.4 MSTRG.23778.1_3 - 1.9e-05 24.3 9.4 7.8e-05 22.3 9.4 1.9 1 1 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.4 MSTRG.23778.1_3 - 0.021 15.2 0.2 0.045 14.1 0.2 1.5 1 0 0 1 1 1 0 PAP2 superfamily C-terminal CAML PF14963.4 MSTRG.935.1_2 - 1.8e-114 382.3 0.0 2.2e-114 382.0 0.0 1.1 1 0 0 1 1 1 1 Calcium signal-modulating cyclophilin ligand DSPc PF00782.18 MSTRG.10433.2_1 - 1.5e-25 89.4 0.0 2.2e-25 88.9 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.10 MSTRG.10433.2_1 - 0.044 14.0 0.0 0.089 13.0 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain YccV-like PF08755.9 MSTRG.24736.1_3 - 8.3e-18 64.6 0.0 1.4e-17 63.8 0.0 1.4 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like ADIP PF11559.6 MSTRG.26205.7_3 - 0.004 17.1 10.9 0.004 17.1 10.9 2.7 3 0 0 3 3 3 1 Afadin- and alpha -actinin-Binding Mitofilin PF09731.7 MSTRG.26205.7_3 - 0.83 8.2 32.7 0.075 11.7 15.4 2.1 2 0 0 2 2 2 0 Mitochondrial inner membrane protein BUD22 PF09073.8 MSTRG.26205.7_3 - 1.3 8.1 54.8 0.031 13.5 43.1 2.3 2 0 0 2 2 2 0 BUD22 Cwf_Cwc_15 PF04889.10 MSTRG.26205.7_3 - 3 7.4 46.9 0.036 13.7 32.2 2.6 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein XK-related PF09815.7 MSTRG.5049.1_1 - 5.6e-100 334.4 30.7 7.2e-100 334.1 30.7 1.1 1 0 0 1 1 1 1 XK-related protein CAP_N PF01213.17 MSTRG.4076.1_1 - 6.3 6.0 5.1 9.7 5.4 5.1 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal SNF2_N PF00176.21 MSTRG.13898.1_1 - 5e-48 163.5 0.0 8.1e-48 162.8 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.29 MSTRG.13898.1_1 - 1.9e-15 57.1 0.0 4e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.13898.1_1 - 1.4e-08 34.8 0.0 3.3e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.3 MSTRG.13898.1_1 - 0.0016 17.6 0.0 0.17 11.0 0.0 2.4 1 1 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase MIP-T3 PF10243.7 MSTRG.13898.1_1 - 4.7 5.7 38.0 8 4.9 38.0 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Peptidase_M14 PF00246.22 MSTRG.27527.1_3 - 2.1e-82 277.1 0.0 2.6e-82 276.8 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.4 MSTRG.27527.1_3 - 2.3e-16 59.7 0.0 3.6e-16 59.1 0.0 1.3 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.4 MSTRG.27527.1_3 - 2.6e-06 27.2 0.0 4.3e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 CarboxypepD_reg-like domain AstE_AspA PF04952.12 MSTRG.27527.1_3 - 0.0081 15.1 0.2 0.017 14.1 0.2 1.4 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family DUF2817 PF10994.6 MSTRG.27527.1_3 - 0.031 13.5 0.1 0.047 12.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2817) JmjC PF02373.20 MSTRG.21113.2_1 - 1.1e-11 45.0 0.1 4.9e-11 43.0 0.1 2.2 1 0 0 1 1 1 1 JmjC domain, hydroxylase C1_2 PF03107.14 MSTRG.21113.2_1 - 0.031 14.4 3.8 0.11 12.7 3.8 2.0 1 0 0 1 1 1 0 C1 domain zf-C5HC2 PF02928.14 MSTRG.21113.2_1 - 0.078 13.2 6.9 0.13 12.5 5.5 2.1 2 0 0 2 2 2 0 C5HC2 zinc finger FYVE PF01363.19 MSTRG.21113.2_1 - 1.1 9.3 6.8 3.9 7.6 6.8 1.9 1 0 0 1 1 1 0 FYVE zinc finger V-set PF07686.15 MSTRG.22767.1_2 - 2e-20 72.8 0.3 6.9e-16 58.2 0.0 3.5 2 1 1 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.4 MSTRG.22767.1_2 - 7.8e-14 51.9 0.9 8.7e-09 35.7 0.5 2.6 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 MSTRG.22767.1_2 - 4.4e-13 49.1 0.1 9.7e-08 32.0 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 MSTRG.22767.1_2 - 2.3e-11 43.4 0.0 4.5e-06 26.5 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.22767.1_2 - 8.2e-10 38.8 0.6 1.8e-06 28.0 0.3 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Adeno_E3_CR2 PF02439.13 MSTRG.22767.1_2 - 0.00059 19.4 4.6 0.0014 18.2 4.6 1.6 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 WBP-1 PF11669.6 MSTRG.22767.1_2 - 0.0021 18.5 0.2 0.0021 18.5 0.2 3.0 3 0 0 3 3 3 1 WW domain-binding protein 1 EphA2_TM PF14575.4 MSTRG.22767.1_2 - 0.0062 17.2 0.3 0.017 15.8 0.0 1.9 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain IncA PF04156.12 MSTRG.22767.1_2 - 0.013 15.2 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 IncA protein Izumo-Ig PF16706.3 MSTRG.22767.1_2 - 0.058 13.3 0.1 19 5.2 0.0 3.3 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain MLANA PF14991.4 MSTRG.22767.1_2 - 0.11 12.6 0.1 0.25 11.5 0.1 1.5 1 0 0 1 1 1 0 Protein melan-A ELFV_dehydrog_N PF02812.16 MSTRG.26421.1_1 - 9.2e-62 206.5 0.0 1.5e-61 205.8 0.0 1.3 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain ELFV_dehydrog PF00208.19 MSTRG.26421.1_1 - 6.8e-51 173.2 0.0 4.2e-49 167.3 0.0 2.1 2 0 0 2 2 2 2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase RWD PF05773.20 MSTRG.9549.2_2 - 4.9e-26 91.2 0.1 7.7e-26 90.5 0.1 1.3 1 0 0 1 1 1 1 RWD domain IBR PF01485.19 MSTRG.9549.2_2 - 1.1e-16 60.7 19.9 5.7e-12 45.6 1.0 4.7 3 1 1 4 4 4 3 IBR domain, a half RING-finger domain CNRIP1 PF15043.4 MSTRG.28172.1_1 - 1.2e-40 138.5 0.3 1.3e-40 138.3 0.3 1.1 1 0 0 1 1 1 1 CB1 cannabinoid receptor-interacting protein 1 Kelch_1 PF01344.23 MSTRG.4229.1_2 - 2.4e-85 279.8 14.7 2.1e-14 52.7 0.2 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 MSTRG.4229.1_2 - 2.6e-44 148.0 1.4 1.5e-07 31.3 0.0 6.5 1 1 5 6 6 6 6 Kelch motif Kelch_3 PF13415.4 MSTRG.4229.1_2 - 1.3e-35 120.9 4.6 2.3e-06 27.6 0.1 6.6 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.13 MSTRG.4229.1_2 - 3.2e-30 102.8 2.8 0.00025 20.7 0.0 6.8 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.4 MSTRG.4229.1_2 - 6.6e-29 99.5 1.0 1.6e-05 24.7 0.0 6.6 5 1 1 6 6 6 5 Galactose oxidase, central domain BTB PF00651.29 MSTRG.4229.1_2 - 1.5e-28 99.1 0.3 2.4e-28 98.4 0.3 1.3 1 0 0 1 1 1 1 BTB/POZ domain Kelch_5 PF13854.4 MSTRG.4229.1_2 - 8.8e-15 54.2 6.5 0.0029 17.4 0.1 5.8 6 0 0 6 6 6 4 Kelch motif BACK PF07707.13 MSTRG.4229.1_2 - 3.6e-12 46.2 0.5 9.3e-12 44.8 0.2 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch PDZ PF00595.22 MSTRG.8004.1_2 - 4.7e-17 62.0 0.1 7.6e-17 61.3 0.1 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.8004.1_2 - 2.8e-06 27.4 0.1 5.7e-06 26.4 0.1 1.4 1 0 0 1 1 1 1 PDZ domain zf-C2H2 PF00096.24 MSTRG.6036.1_2 - 8.8e-29 98.2 98.4 0.00025 21.2 0.2 13.7 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.6036.1_2 - 1.2e-22 79.2 95.1 1.3e-06 28.4 4.4 12.3 13 0 0 13 13 12 6 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.6036.1_2 - 5.8e-19 67.0 102.2 0.015 16.0 0.4 13.9 13 0 0 13 13 13 10 C2H2-type zinc finger BTB PF00651.29 MSTRG.6036.1_2 - 8.4e-19 67.7 0.3 4.7e-18 65.3 0.0 2.3 2 0 0 2 2 2 1 BTB/POZ domain zf-Di19 PF05605.10 MSTRG.6036.1_2 - 8.2e-05 22.7 8.4 8.2e-05 22.7 8.4 9.2 3 2 9 12 12 12 6 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.6 MSTRG.6036.1_2 - 0.012 15.8 55.6 0.32 11.2 0.9 10.5 11 0 0 11 11 9 0 Zinc-finger double-stranded RNA-binding PHD PF00628.27 MSTRG.6036.1_2 - 0.038 13.8 0.6 0.038 13.8 0.6 8.6 7 2 1 9 9 8 0 PHD-finger zf-C2H2_6 PF13912.4 MSTRG.6036.1_2 - 0.16 11.8 0.1 0.16 11.8 0.1 11.9 12 0 0 12 12 12 0 C2H2-type zinc finger zf-C2H2_11 PF16622.3 MSTRG.6036.1_2 - 0.18 11.4 0.0 0.18 11.4 0.0 11.4 13 0 0 13 13 12 0 zinc-finger C2H2-type zf-met PF12874.5 MSTRG.6036.1_2 - 0.42 10.9 55.4 1 9.7 0.0 9.9 10 0 0 10 10 9 0 Zinc-finger of C2H2 type GAGA PF09237.9 MSTRG.6036.1_2 - 1.2 8.9 14.0 1 9.1 0.0 5.4 5 1 1 6 6 6 0 GAGA factor zf-H2C2_5 PF13909.4 MSTRG.6036.1_2 - 7 6.4 32.1 0.56 9.9 0.1 7.3 7 0 0 7 7 6 0 C2H2-type zinc-finger domain COR PF16095.3 MSTRG.9069.1_2 - 1.1e-10 41.5 0.0 1.2e-09 38.1 0.0 2.5 1 1 0 1 1 1 1 C-terminal of Roc, COR, domain Roc PF08477.11 MSTRG.9069.1_2 - 1.7e-08 34.6 0.0 2.8e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.9069.1_2 - 3.6e-06 26.4 0.0 7.1e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family LRR_8 PF13855.4 MSTRG.9069.1_2 - 0.00014 21.4 2.1 0.00023 20.7 1.0 2.0 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.5 MSTRG.9069.1_2 - 0.032 14.5 0.9 0.11 12.8 0.9 2.0 1 0 0 1 1 1 0 Leucine Rich repeats (2 copies) Ras PF00071.20 MSTRG.9069.1_2 - 0.05 13.1 0.0 0.08 12.4 0.0 1.3 1 0 0 1 1 1 0 Ras family DUF429 PF04250.11 MSTRG.9069.1_2 - 0.1 12.3 0.1 0.99 9.0 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF429) 7TMR-HDED PF07697.9 MSTRG.9069.1_2 - 0.14 12.1 0.2 0.24 11.3 0.2 1.4 1 0 0 1 1 1 0 7TM-HD extracellular UCH PF00443.27 MSTRG.7169.2_3 - 3e-70 236.5 0.6 3.5e-70 236.3 0.6 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 MSTRG.7169.2_3 - 4.1e-27 95.5 1.5 5.4e-27 95.1 1.5 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-C2HE PF16278.3 MSTRG.7169.2_3 - 1.3 9.4 0.0 1.3 9.4 0.0 3.2 3 0 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger HisKA PF00512.23 MSTRG.8948.1_1 - 0.11 12.5 0.1 0.16 11.9 0.1 1.2 1 0 0 1 1 1 0 His Kinase A (phospho-acceptor) domain Mito_fiss_reg PF05308.9 MSTRG.24242.1_2 - 0.088 12.7 1.1 0.18 11.7 1.1 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator RRM_1 PF00076.20 MSTRG.24242.1_3 - 6.9e-18 64.1 0.0 1.3e-17 63.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DOCK_N PF16172.3 MSTRG.4877.6_3 - 5e-112 374.4 0.4 9.3e-112 373.5 0.4 1.5 1 0 0 1 1 1 1 DOCK N-terminus DHR-2 PF06920.11 MSTRG.4877.6_3 - 3.2e-86 290.0 7.1 1.3e-71 241.7 0.7 2.5 2 0 0 2 2 2 2 Dock homology region 2 DOCK-C2 PF14429.4 MSTRG.4877.6_3 - 1.6e-60 204.1 0.2 3.9e-60 202.9 0.2 1.7 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DUF4407 PF14362.4 MSTRG.5175.1_1 - 0.17 11.1 3.7 0.19 10.9 3.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SpecificRecomb PF10136.7 MSTRG.5175.1_1 - 0.38 8.9 5.1 0.41 8.8 5.1 1.0 1 0 0 1 1 1 0 Site-specific recombinase Mnd1 PF03962.13 MSTRG.5175.1_1 - 0.58 9.9 4.8 0.73 9.5 4.8 1.2 1 0 0 1 1 1 0 Mnd1 family IncA PF04156.12 MSTRG.5175.1_1 - 0.59 9.8 10.2 1.1 8.9 10.2 1.5 1 1 0 1 1 1 0 IncA protein Cep57_CLD_2 PF14197.4 MSTRG.5175.1_1 - 1.2 9.2 7.6 1.8 8.6 0.7 2.9 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 Tetraspannin PF00335.18 MSTRG.11532.1_1 - 1.2e-54 185.2 8.9 1.2e-54 185.2 8.9 2.2 2 0 0 2 2 2 2 Tetraspanin family Ldl_recept_a PF00057.16 MSTRG.11284.1_2 - 1.2e-46 156.4 98.4 8.8e-14 51.3 16.2 5.3 5 0 0 5 5 5 4 Low-density lipoprotein receptor domain class A Ldl_recept_a PF00057.16 MSTRG.11284.1_3 - 1.6e-05 24.9 1.6 3e-05 24.0 1.6 1.5 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A YrzO PF14142.4 MSTRG.26949.1_1 - 0.031 14.0 0.1 0.058 13.2 0.1 1.4 1 0 0 1 1 1 0 YrzO-like protein RRM_1 PF00076.20 MSTRG.13796.7_3 - 5.9e-14 51.5 0.0 9.5e-14 50.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.13796.7_3 - 0.019 14.9 0.0 0.035 14.1 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif ODC_AZ PF02100.15 MSTRG.9796.1_2 - 8.8e-18 64.2 0.0 1.5e-17 63.5 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Jun PF03957.11 MSTRG.10584.1_3 - 1.3e-51 175.6 1.8 1.8e-51 175.1 1.8 1.2 1 0 0 1 1 1 1 Jun-like transcription factor bZIP_1 PF00170.19 MSTRG.10584.1_3 - 1.2e-16 60.4 12.4 1.9e-16 59.7 12.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.15 MSTRG.10584.1_3 - 5.5e-08 33.1 7.0 1.1e-07 32.1 7.0 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_2 PF07716.13 MSTRG.10584.1_3 - 1e-06 28.5 9.7 2.4e-06 27.4 9.7 1.6 1 0 0 1 1 1 1 Basic region leucine zipper ZapB PF06005.10 MSTRG.10584.1_3 - 0.02 15.2 0.8 0.046 14.0 0.8 1.5 1 0 0 1 1 1 0 Cell division protein ZapB PspA_IM30 PF04012.10 MSTRG.10584.1_3 - 0.026 14.0 1.3 0.04 13.4 1.3 1.2 1 0 0 1 1 1 0 PspA/IM30 family Jnk-SapK_ap_N PF09744.7 MSTRG.10584.1_3 - 0.29 11.2 3.4 0.47 10.5 3.4 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Ank_2 PF12796.5 MSTRG.5768.1_2 - 3.7e-35 120.2 3.6 5.5e-19 68.4 0.3 2.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.5768.1_2 - 6.8e-21 74.2 0.4 5e-10 39.6 0.2 3.9 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.5768.1_2 - 6.3e-20 69.0 0.6 0.00048 20.2 0.0 5.9 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.4 MSTRG.5768.1_2 - 5.9e-18 64.5 0.8 1.4e-06 28.4 0.0 4.9 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.5768.1_2 - 7.1e-18 64.1 1.3 3.1e-05 24.1 0.0 4.9 4 0 0 4 4 4 4 Ankyrin repeat EloA-BP1 PF15870.3 MSTRG.10667.1_1 - 5e-61 205.7 0.1 5e-61 205.7 0.1 4.5 2 1 0 2 2 2 1 ElonginA binding-protein 1 Pkinase PF00069.23 MSTRG.2506.3_3 - 2.4e-10 40.1 0.0 3.8e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.2506.3_3 - 6.2e-05 22.3 0.0 0.0094 15.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase DUF5102 PF17104.3 MSTRG.19341.1_1 - 9.7 6.0 6.9 0.48 10.3 1.7 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5102) Homeobox PF00046.27 MSTRG.22194.1_3 - 3.6e-11 42.6 0.3 6.5e-11 41.8 0.3 1.4 1 0 0 1 1 1 1 Homeobox domain Acetyltransf_13 PF13880.4 MSTRG.13321.1_2 - 6.1e-29 99.7 0.0 1.2e-28 98.7 0.0 1.6 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.4 MSTRG.13321.1_2 - 5.8e-13 48.3 0.3 1.3e-12 47.2 0.3 1.6 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Myc_target_1 PF15179.4 MSTRG.19914.2_2 - 5.5e-56 189.4 0.0 1e-55 188.5 0.0 1.5 1 0 0 1 1 1 1 Myc target protein 1 ATP-synt_I PF03899.13 MSTRG.19914.2_2 - 0.029 14.6 0.0 0.046 13.9 0.0 1.2 1 0 0 1 1 1 0 ATP synthase I chain RBD-FIP PF09457.8 MSTRG.18432.1_1 - 1.7e-07 30.9 1.2 3e-07 30.1 1.2 1.4 1 0 0 1 1 1 1 FIP domain Cast PF10174.7 MSTRG.18432.1_3 - 3.6e-56 190.7 25.8 4.2e-56 190.5 25.8 1.0 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone zf-C4H2 PF10146.7 MSTRG.18432.1_3 - 0.015 15.4 7.6 0.025 14.8 7.6 1.2 1 0 0 1 1 1 0 Zinc finger-containing protein Fez1 PF06818.13 MSTRG.18432.1_3 - 0.35 11.2 15.8 0.48 10.7 15.8 1.1 1 0 0 1 1 1 0 Fez1 HIP1_clath_bdg PF16515.3 MSTRG.18432.1_3 - 1.8 9.1 17.5 1.6 9.3 4.2 2.4 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 HLH PF00010.24 MSTRG.24073.1_2 - 3.5e-13 49.1 1.1 3.5e-13 49.1 1.1 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain zf-C4H2 PF10146.7 MSTRG.24073.1_2 - 0.022 14.9 3.8 0.036 14.2 3.8 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein Sipho_Gp157 PF05565.9 MSTRG.24073.1_2 - 0.061 13.2 8.6 0.096 12.6 8.6 1.4 1 1 0 1 1 1 0 Siphovirus Gp157 THOC7 PF05615.11 MSTRG.24073.1_2 - 0.07 13.3 8.1 0.1 12.7 8.1 1.2 1 0 0 1 1 1 0 Tho complex subunit 7 DUF773 PF05600.10 MSTRG.24073.1_2 - 0.074 11.7 7.3 0.096 11.3 7.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF773) LMBR1 PF04791.14 MSTRG.24073.1_2 - 0.26 10.0 4.0 0.33 9.7 4.0 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Fmp27_WPPW PF10359.7 MSTRG.24073.1_2 - 0.34 9.6 7.4 0.44 9.2 7.4 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain AAA_13 PF13166.4 MSTRG.24073.1_2 - 0.66 8.4 8.2 0.8 8.2 8.2 1.0 1 0 0 1 1 1 0 AAA domain APG6 PF04111.10 MSTRG.24073.1_2 - 1.1 8.5 10.8 1.4 8.1 10.8 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.12 MSTRG.24073.1_2 - 1.5 8.5 11.2 2 8.0 11.2 1.2 1 0 0 1 1 1 0 IncA protein DUF1664 PF07889.10 MSTRG.24073.1_2 - 2.6 7.9 4.8 9.8 6.1 0.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CLIP1_ZNF PF16641.3 MSTRG.20889.1_2 - 1.7e-15 56.3 16.1 1.4e-07 31.1 1.9 2.9 2 0 0 2 2 2 2 CLIP1 zinc knuckle KASH_CCD PF14662.4 MSTRG.20889.1_2 - 0.86 9.3 35.4 0.08 12.7 23.2 2.2 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Prefoldin_2 PF01920.18 MSTRG.20889.1_2 - 2.6 7.9 33.4 0.079 12.8 2.7 4.3 3 1 1 4 4 4 0 Prefoldin subunit Pkinase PF00069.23 MSTRG.12480.2_2 - 1e-61 208.5 0.0 1.6e-61 207.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain CNH PF00780.20 MSTRG.12480.2_2 - 2e-58 198.1 0.0 2.9e-58 197.5 0.0 1.2 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.15 MSTRG.12480.2_2 - 6.9e-46 156.5 0.0 1.1e-45 155.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.12480.2_2 - 0.0065 15.7 0.0 0.0065 15.7 0.0 2.2 3 0 0 3 3 3 1 Kinase-like Gemin6 PF06372.10 MSTRG.19294.1_1 - 4.5e-18 65.2 0.0 6.3e-18 64.7 0.0 1.1 1 0 0 1 1 1 1 Gemin6 protein TgMIC1 PF11476.6 MSTRG.19294.1_1 - 0.12 12.0 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Toxoplasma gondii micronemal protein 1 TgMIC1 Peptidase_C14 PF00656.20 MSTRG.9984.3_2 - 2.1e-41 142.4 0.0 2.7e-41 142.0 0.0 1.1 1 0 0 1 1 1 1 Caspase domain CARD PF00619.19 MSTRG.9984.3_2 - 9.9e-16 57.4 0.4 2.5e-15 56.2 0.4 1.6 1 0 0 1 1 1 1 Caspase recruitment domain DUF2773 PF10971.6 MSTRG.26821.6_1 - 2.9 8.0 4.9 6.7 6.8 0.0 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF2773) Thyroglobulin_1 PF00086.16 MSTRG.26821.6_3 - 2.3e-145 472.3 99.6 2.8e-19 68.4 7.4 8.3 8 0 0 8 8 8 8 Thyroglobulin type-1 repeat Ldl_recept_b PF00058.15 MSTRG.26821.6_3 - 9.6e-31 105.9 2.3 3.2e-11 43.4 0.1 4.6 5 0 0 5 5 5 3 Low-density lipoprotein receptor repeat class B DUF1416 PF07210.10 MSTRG.26821.6_3 - 5.7e-05 22.8 0.0 65 3.4 0.0 6.4 7 0 0 7 7 7 0 Protein of unknown function (DUF1416) SGL PF08450.10 MSTRG.26821.6_3 - 0.0072 15.8 0.1 0.043 13.2 0.1 2.8 1 1 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region Cadherin PF00028.15 MSTRG.12406.1_1 - 8e-33 112.6 0.2 2e-18 66.5 0.1 2.2 2 0 0 2 2 2 2 Cadherin domain Cadherin_2 PF08266.10 MSTRG.12406.1_1 - 0.0042 16.7 0.0 0.97 9.2 0.0 2.5 2 0 0 2 2 2 2 Cadherin-like PHD PF00628.27 MSTRG.7191.4_3 - 2.4e-10 40.0 4.9 9.6e-10 38.1 4.9 2.2 1 0 0 1 1 1 1 PHD-finger WHIM1 PF15612.4 MSTRG.7191.4_3 - 4.8e-08 32.3 0.0 1.1e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 DDT PF02791.15 MSTRG.7191.4_3 - 0.0019 18.3 0.0 0.0037 17.4 0.0 1.4 1 0 0 1 1 1 1 DDT domain WSD PF15613.4 MSTRG.7191.4_3 - 0.021 15.2 0.0 0.021 15.2 0.0 5.1 4 1 0 4 4 4 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif bZIP_1 PF00170.19 MSTRG.20467.3_1 - 3e-08 33.5 11.3 4.9e-08 32.8 11.3 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 MSTRG.20467.3_1 - 0.0024 17.8 9.1 0.0024 17.8 9.1 2.3 1 1 1 2 2 2 1 Basic region leucine zipper FlaC_arch PF05377.9 MSTRG.20467.3_1 - 0.0033 17.7 3.2 0.0033 17.7 3.2 1.8 2 0 0 2 2 1 1 Flagella accessory protein C (FlaC) KLRAQ PF10205.7 MSTRG.20467.3_1 - 0.0034 17.5 5.2 0.0057 16.7 5.2 1.2 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein DUF972 PF06156.11 MSTRG.20467.3_1 - 0.05 14.1 3.2 0.096 13.2 3.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF972) HAP1_N PF04849.11 MSTRG.20467.3_1 - 0.069 12.2 4.6 0.099 11.7 4.6 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region DUF4618 PF15397.4 MSTRG.20467.3_1 - 0.078 12.3 5.2 0.11 11.7 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Kinetocho_Slk19 PF12709.5 MSTRG.20467.3_1 - 0.2 12.0 3.9 0.38 11.1 3.9 1.4 1 0 0 1 1 1 0 Central kinetochore-associated bZIP_Maf PF03131.15 MSTRG.20467.3_1 - 0.22 12.0 5.3 0.43 11.0 5.3 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor ZapB PF06005.10 MSTRG.20467.3_1 - 0.38 11.1 4.9 0.54 10.6 3.9 1.7 1 1 0 1 1 1 0 Cell division protein ZapB CENP-H PF05837.10 MSTRG.20467.3_1 - 0.43 10.9 6.6 0.4 11.0 5.1 1.6 1 1 0 1 1 1 0 Centromere protein H (CENP-H) DivIC PF04977.13 MSTRG.20467.3_1 - 2 8.1 6.0 1.4 8.6 3.8 1.8 1 1 1 2 2 2 0 Septum formation initiator Cytochrom_C1 PF02167.13 MSTRG.26624.1_3 - 2.8e-97 324.6 0.0 3.4e-97 324.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.4 MSTRG.26624.1_3 - 0.00092 19.4 0.0 0.002 18.3 0.0 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.19 MSTRG.26624.1_3 - 0.0052 17.8 0.0 0.012 16.7 0.0 1.7 1 0 0 1 1 1 1 Cytochrome c DUF4749 PF15936.3 MSTRG.21881.1_1 - 4.1e-23 82.3 1.1 4.4e-23 82.1 0.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4749) PDZ PF00595.22 MSTRG.21881.1_1 - 2.3e-11 43.7 0.0 4.4e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.21881.1_1 - 0.0064 16.7 0.0 0.013 15.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Mito_carr PF00153.25 MSTRG.27796.1_2 - 1.3e-59 198.0 5.6 4.8e-21 74.4 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein MFS_1 PF07690.14 MSTRG.15791.1_1 - 7.4e-16 57.9 15.3 7.4e-16 57.9 15.3 2.4 2 1 1 3 3 3 2 Major Facilitator Superfamily Neurensin PF14927.4 MSTRG.15791.1_1 - 0.00038 20.1 0.2 0.025 14.2 0.0 3.6 4 1 0 4 4 4 1 Neurensin PRIMA1 PF16101.3 MSTRG.4595.1_3 - 6.6 6.7 7.0 19 5.2 7.0 1.8 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CLP1_P PF16575.3 MSTRG.15786.1_2 - 6.3e-74 247.7 0.0 9.4e-74 247.2 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.3 MSTRG.15786.1_2 - 7.3e-31 106.1 0.1 1.4e-30 105.2 0.1 1.5 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor Clp1 PF06807.12 MSTRG.15786.1_2 - 3.6e-30 104.7 0.0 5.4e-30 104.1 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 ATP_bind_1 PF03029.15 MSTRG.15786.1_2 - 0.019 14.6 0.1 0.032 13.9 0.1 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.21 MSTRG.15786.1_2 - 0.021 14.8 0.0 0.044 13.7 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase TniB PF05621.9 MSTRG.15786.1_2 - 0.18 10.8 0.0 0.3 10.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein AAA PF00004.27 MSTRG.21910.1_3 - 3.2e-57 192.5 0.0 1.8e-40 138.3 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.16 MSTRG.21910.1_3 - 2.1e-11 43.7 0.0 4.6e-10 39.4 0.0 2.8 2 1 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain AAA_22 PF13401.4 MSTRG.21910.1_3 - 2.7e-09 37.3 0.4 0.0054 16.9 0.3 4.6 3 2 1 4 4 3 1 AAA domain RNA_helicase PF00910.20 MSTRG.21910.1_3 - 7.5e-08 32.6 0.0 0.015 15.5 0.0 3.0 2 0 0 2 2 2 2 RNA helicase RuvB_N PF05496.10 MSTRG.21910.1_3 - 1.5e-07 30.8 0.0 0.012 14.8 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.4 MSTRG.21910.1_3 - 3.5e-07 30.6 0.2 0.0064 16.8 0.1 3.2 2 2 0 2 2 2 2 AAA ATPase domain AAA_2 PF07724.12 MSTRG.21910.1_3 - 3.7e-07 30.3 0.0 1.7e-05 24.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) CDC48_2 PF02933.15 MSTRG.21910.1_3 - 6.2e-07 29.0 1.6 2.2e-06 27.2 0.2 2.2 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_14 PF13173.4 MSTRG.21910.1_3 - 1e-06 28.7 0.1 0.064 13.2 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_5 PF07728.12 MSTRG.21910.1_3 - 1.6e-06 28.0 0.4 0.0012 18.8 0.1 3.4 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) TIP49 PF06068.11 MSTRG.21910.1_3 - 2.2e-06 26.8 0.0 0.023 13.5 0.0 2.4 2 0 0 2 2 2 2 TIP49 C-terminus ATPase_2 PF01637.16 MSTRG.21910.1_3 - 4.7e-06 26.5 0.1 0.61 9.8 0.0 4.0 2 2 2 4 4 4 1 ATPase domain predominantly from Archaea AAA_18 PF13238.4 MSTRG.21910.1_3 - 6.3e-06 26.6 0.0 0.028 14.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.19 MSTRG.21910.1_3 - 1.1e-05 24.8 0.1 0.0053 16.0 0.1 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI TsaE PF02367.15 MSTRG.21910.1_3 - 5.7e-05 23.0 0.0 0.092 12.6 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.4 MSTRG.21910.1_3 - 0.00013 21.7 0.0 0.16 11.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.4 MSTRG.21910.1_3 - 0.00014 21.9 0.0 0.29 11.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain NACHT PF05729.10 MSTRG.21910.1_3 - 0.0002 21.2 0.0 0.97 9.2 0.0 3.5 3 1 0 3 3 3 2 NACHT domain ATPase PF06745.11 MSTRG.21910.1_3 - 0.0013 18.0 0.1 0.023 13.9 0.1 2.7 2 1 1 3 3 3 1 KaiC AAA_17 PF13207.4 MSTRG.21910.1_3 - 0.0017 18.7 0.0 2.4 8.4 0.0 3.3 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.25 MSTRG.21910.1_3 - 0.0017 18.8 0.2 0.022 15.1 0.0 2.8 3 0 0 3 3 3 1 ABC transporter AAA_3 PF07726.9 MSTRG.21910.1_3 - 0.0021 17.8 0.0 0.34 10.6 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.24 MSTRG.21910.1_3 - 0.0027 17.3 0.0 1 8.9 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain NB-ARC PF00931.20 MSTRG.21910.1_3 - 0.0057 15.6 0.0 0.47 9.3 0.1 2.6 2 0 0 2 2 2 1 NB-ARC domain Parvo_NS1 PF01057.15 MSTRG.21910.1_3 - 0.0058 15.6 0.0 2.8 6.8 0.0 2.5 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 IstB_IS21 PF01695.15 MSTRG.21910.1_3 - 0.0062 16.2 0.0 0.32 10.6 0.0 2.8 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_28 PF13521.4 MSTRG.21910.1_3 - 0.008 16.3 0.0 0.98 9.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.10 MSTRG.21910.1_3 - 0.013 14.7 0.0 2.4 7.3 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin AAA_11 PF13086.4 MSTRG.21910.1_3 - 0.015 14.9 0.0 1.4 8.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.4 MSTRG.21910.1_3 - 0.016 14.7 0.4 2.4 7.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain KTI12 PF08433.8 MSTRG.21910.1_3 - 0.016 14.5 0.2 8.2 5.6 0.0 3.1 3 0 0 3 3 3 0 Chromatin associated protein KTI12 Methyltransf_21 PF05050.10 MSTRG.21910.1_3 - 0.041 13.8 0.0 0.077 12.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase FkbM domain Cullin PF00888.20 MSTRG.14744.1_3 - 1.1e-14 53.9 0.2 1.4e-14 53.5 0.2 1.1 1 0 0 1 1 1 1 Cullin family WND PF07861.9 MSTRG.14744.1_3 - 0.013 14.9 0.3 0.02 14.2 0.3 1.2 1 0 0 1 1 1 0 WisP family N-Terminal Region SIR2 PF02146.15 MSTRG.12776.1_3 - 3.4e-44 150.7 0.0 5.1e-44 150.2 0.0 1.3 1 0 0 1 1 1 1 Sir2 family PNTB PF02233.14 MSTRG.12776.1_3 - 0.032 13.0 0.0 0.13 11.1 0.0 1.7 2 0 0 2 2 2 0 NAD(P) transhydrogenase beta subunit TPP_enzyme_M PF00205.20 MSTRG.12776.1_3 - 0.17 11.5 0.0 4.4 6.9 0.0 2.3 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain IF-2B PF01008.15 MSTRG.24707.1_2 - 1.8e-75 253.6 0.0 2.2e-75 253.3 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Prominin PF05478.9 MSTRG.17865.2_1 - 1.9e-27 95.5 0.8 2.4e-27 95.2 0.8 1.0 1 0 0 1 1 1 1 Prominin Prominin PF05478.9 MSTRG.17865.2_2 - 2.9e-119 399.2 0.5 4e-119 398.7 0.5 1.0 1 0 0 1 1 1 1 Prominin zf-RING_UBOX PF13445.4 MSTRG.8614.2_3 - 6.7e-06 25.9 10.1 7.4e-06 25.7 7.5 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.4 MSTRG.8614.2_3 - 2.6e-05 24.3 6.3 2.6e-05 24.3 6.3 3.7 4 0 0 4 4 4 1 Ring finger domain zf-RING_5 PF14634.4 MSTRG.8614.2_3 - 5.5e-05 22.9 7.1 5.5e-05 22.9 7.1 2.6 3 0 0 3 3 3 1 zinc-RING finger domain zf-CCCH PF00642.22 MSTRG.8614.2_3 - 0.00018 21.2 3.0 0.00018 21.2 3.0 2.3 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_4 PF15227.4 MSTRG.8614.2_3 - 0.0047 16.9 5.7 0.0047 16.9 5.7 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 MSTRG.8614.2_3 - 0.028 14.1 11.2 0.027 14.2 6.6 3.5 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 MSTRG.8614.2_3 - 0.12 12.2 9.8 0.064 13.0 6.2 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 MSTRG.8614.2_3 - 0.71 9.6 17.9 0.0081 15.9 3.4 3.3 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.4 MSTRG.8614.2_3 - 1.1 8.9 11.3 0.059 13.0 3.9 2.8 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain Mak10 PF04112.11 MSTRG.5741.1_2 - 4.6e-35 120.5 2.9 3.5e-26 91.6 0.1 2.6 2 1 1 3 3 3 2 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase FERM_M PF00373.16 MSTRG.7299.1_3 - 6.2e-44 149.0 0.0 3.1e-43 146.8 0.0 2.2 2 1 0 2 2 2 1 FERM central domain PH PF00169.27 MSTRG.7299.1_3 - 2.7e-11 43.8 0.0 7.5e-11 42.3 0.0 1.8 1 0 0 1 1 1 1 PH domain FERM_N PF09379.8 MSTRG.7299.1_3 - 0.00033 20.4 0.0 0.00081 19.2 0.0 1.7 1 0 0 1 1 1 1 FERM N-terminal domain PH_8 PF15409.4 MSTRG.7299.1_3 - 0.032 14.4 0.0 0.1 12.8 0.0 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain tRNA_m1G_MT PF01746.19 MSTRG.25842.2_2 - 1.6e-30 106.2 0.0 2.5e-30 105.5 0.0 1.3 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase IncFII_repA PF02387.13 MSTRG.25842.2_2 - 0.00062 18.9 4.9 0.00092 18.3 4.9 1.2 1 0 0 1 1 1 1 IncFII RepA protein family DEPP PF15343.4 MSTRG.25842.2_2 - 0.45 10.5 7.9 0.85 9.6 7.9 1.5 1 0 0 1 1 1 0 Decidual protein induced by progesterone family PWWP PF00855.15 MSTRG.1243.2_1 - 7.1e-19 67.9 0.4 1.6e-18 66.8 0.4 1.7 1 0 0 1 1 1 1 PWWP domain HTH_28 PF13518.4 MSTRG.1243.2_1 - 0.0005 20.0 0.0 0.0012 18.8 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain Sigma70_r4_2 PF08281.10 MSTRG.1243.2_1 - 0.0028 17.2 0.0 0.006 16.1 0.0 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_23 PF13384.4 MSTRG.1243.2_1 - 0.0028 17.3 0.1 0.0063 16.1 0.1 1.6 1 0 0 1 1 1 1 Homeodomain-like domain Sigma70_r4 PF04545.14 MSTRG.1243.2_1 - 0.089 12.2 0.0 0.22 11.0 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 CBP_BcsN PF17038.3 MSTRG.1243.2_1 - 0.14 11.2 7.8 0.16 11.1 0.2 2.3 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsN DUF4719 PF15843.3 MSTRG.1243.2_1 - 0.39 10.7 4.3 0.44 10.5 0.5 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4719) HTH_32 PF13565.4 MSTRG.1243.2_1 - 3.9 8.0 7.7 0.35 11.4 0.3 2.8 3 1 0 3 3 3 0 Homeodomain-like domain LRR_8 PF13855.4 MSTRG.18444.2_2 - 1.1e-42 143.5 34.6 4.3e-16 58.3 0.9 4.4 2 2 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 MSTRG.18444.2_2 - 1.1e-16 60.4 15.9 1.2e-05 25.4 1.4 5.3 4 1 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 MSTRG.18444.2_2 - 3e-10 39.7 1.3 6.7e-06 25.6 0.4 2.5 2 0 0 2 2 2 2 Leucine-rich repeat LRR_5 PF13306.4 MSTRG.18444.2_2 - 1.7e-09 37.6 0.0 0.00028 20.7 0.0 2.4 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_1 PF00560.31 MSTRG.18444.2_2 - 2.3e-05 24.1 18.0 5.5 7.7 0.1 7.2 6 1 0 6 6 6 2 Leucine Rich Repeat LRRNT PF01462.16 MSTRG.18444.2_2 - 5.9e-05 22.5 0.1 5.9e-05 22.5 0.1 4.2 4 0 0 4 4 4 1 Leucine rich repeat N-terminal domain LRR_6 PF13516.4 MSTRG.18444.2_2 - 0.053 13.5 21.8 1 9.4 0.2 6.1 6 0 0 6 6 6 0 Leucine Rich repeat TMEM154 PF15102.4 MSTRG.3740.2_1 - 0.00095 19.0 0.0 0.0016 18.2 0.0 1.3 1 0 0 1 1 1 1 TMEM154 protein family DUF3377 PF11857.6 MSTRG.3740.2_1 - 0.0068 16.2 0.1 0.016 15.0 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) ECSCR PF15820.3 MSTRG.3740.2_1 - 0.024 14.3 0.1 0.046 13.4 0.1 1.3 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator IncA PF04156.12 MSTRG.3740.2_1 - 0.026 14.2 0.0 0.046 13.4 0.0 1.3 1 0 0 1 1 1 0 IncA protein CD34_antigen PF06365.10 MSTRG.3740.2_1 - 0.046 13.2 0.2 0.11 12.0 0.0 1.6 2 0 0 2 2 2 0 CD34/Podocalyxin family SIT PF15330.4 MSTRG.3740.2_1 - 0.057 13.7 0.1 0.42 10.9 0.0 2.1 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT DUF4448 PF14610.4 MSTRG.3740.2_1 - 0.07 12.8 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) EphA2_TM PF14575.4 MSTRG.3740.2_1 - 0.089 13.5 0.0 0.2 12.4 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Defensin_beta_2 PF13841.4 MSTRG.3740.2_2 - 0.36 11.2 2.4 6 7.3 0.3 2.7 2 0 0 2 2 2 0 Beta defensin Ribosomal_S17_N PF16205.3 MSTRG.24664.3_1 - 9.9e-09 35.3 0.5 9.9e-09 35.3 0.5 1.6 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.18 MSTRG.24664.3_2 - 5.9e-14 51.8 0.3 9.2e-14 51.2 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 Ribosomal_S17_N PF16205.3 MSTRG.24664.3_3 - 3.1e-35 120.2 2.7 5.3e-32 109.9 1.1 2.5 3 0 0 3 3 3 2 Ribosomal_S17 N-terminal Trypsin PF00089.24 MSTRG.3362.1_1 - 1.8e-66 224.0 0.2 2.5e-66 223.5 0.2 1.2 1 0 0 1 1 1 1 Trypsin Gla PF00594.18 MSTRG.3362.1_1 - 3.5e-19 68.6 7.5 6.5e-19 67.7 7.5 1.5 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FXa_inhibition PF14670.4 MSTRG.3362.1_1 - 2.8e-10 40.2 24.8 1.7e-07 31.3 7.4 2.6 2 0 0 2 2 2 2 Coagulation Factor Xa inhibitory site EGF PF00008.25 MSTRG.3362.1_1 - 6.1e-09 35.9 7.1 6.1e-09 35.9 7.1 3.1 3 0 0 3 3 3 2 EGF-like domain Trypsin_2 PF13365.4 MSTRG.3362.1_1 - 1.3e-05 26.0 0.0 2.5e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain hEGF PF12661.5 MSTRG.3362.1_1 - 8.9e-05 22.9 2.4 8.9e-05 22.9 2.4 3.8 3 1 0 3 3 3 1 Human growth factor-like EGF cEGF PF12662.5 MSTRG.3362.1_1 - 0.00037 20.2 13.3 0.013 15.3 1.7 2.9 3 0 0 3 3 3 2 Complement Clr-like EGF-like DUF1986 PF09342.9 MSTRG.3362.1_1 - 0.0045 17.2 0.0 0.0089 16.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) EGF_3 PF12947.5 MSTRG.3362.1_1 - 1 9.5 25.6 0.063 13.4 10.6 3.4 2 1 0 2 2 2 0 EGF domain Laminin_EGF PF00053.22 MSTRG.3362.1_1 - 6.9 6.8 22.5 1.2 9.2 9.6 2.9 1 1 1 2 2 2 0 Laminin EGF domain CcmH PF03918.12 MSTRG.1996.1_1 - 0.06 12.5 0.2 0.11 11.6 0.2 1.5 1 0 0 1 1 1 0 Cytochrome C biogenesis protein HABP4_PAI-RBP1 PF04774.13 MSTRG.1996.1_3 - 3.8e-24 85.6 7.9 9.4e-24 84.4 0.3 2.6 2 0 0 2 2 2 1 Hyaluronan / mRNA binding family IHABP4_N PF16174.3 MSTRG.1996.1_3 - 9.9e-15 55.4 10.4 9.9e-15 55.4 10.4 1.9 1 1 0 1 1 1 1 Intracellular hyaluronan-binding protein 4 N-terminal CCDC106 PF15794.3 MSTRG.1996.1_3 - 0.002 17.7 4.2 0.028 14.0 0.0 2.2 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 106 RBP_receptor PF14752.4 MSTRG.11306.1_2 - 1.1e-95 321.4 6.2 1.3e-95 321.2 6.2 1.0 1 0 0 1 1 1 1 Retinol binding protein receptor Lysyl_oxidase PF01186.15 MSTRG.5492.1_3 - 3.8e-30 104.9 0.8 4.7e-30 104.7 0.8 1.1 1 0 0 1 1 1 1 Lysyl oxidase CARDB PF07705.9 MSTRG.5492.1_3 - 0.12 12.5 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 CARDB zf-RING_UBOX PF13445.4 MSTRG.2221.1_3 - 9.8e-08 31.8 7.2 2.4e-07 30.5 7.2 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 MSTRG.2221.1_3 - 4.5e-07 29.5 4.6 4.5e-07 29.5 4.6 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 MSTRG.2221.1_3 - 6.6e-06 26.0 6.0 6.6e-06 26.0 6.0 1.7 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 MSTRG.2221.1_3 - 1.6e-05 24.5 5.2 1.6e-05 24.5 5.2 1.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 MSTRG.2221.1_3 - 3.6e-05 23.4 6.1 3.6e-05 23.4 6.1 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.2221.1_3 - 5.2e-05 23.3 4.9 0.00013 22.0 4.9 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.4 MSTRG.2221.1_3 - 0.00011 22.0 4.0 0.00011 22.0 4.0 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_6 PF14835.4 MSTRG.2221.1_3 - 0.00017 21.2 2.7 0.0003 20.5 2.7 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.4 MSTRG.2221.1_3 - 0.045 13.5 9.8 0.46 10.2 7.6 3.1 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.3 MSTRG.2221.1_3 - 0.06 13.4 5.8 0.06 13.4 5.8 2.0 3 0 0 3 3 3 0 zinc RING finger of MSL2 Aha1_N PF09229.9 MSTRG.1257.4_3 - 1e-36 126.0 0.1 1.8e-36 125.2 0.1 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.9 MSTRG.1257.4_3 - 1.8e-21 76.5 0.0 3e-21 75.8 0.0 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein PCI PF01399.25 MSTRG.20912.1_3 - 5.1e-18 65.4 1.2 2e-17 63.5 0.0 2.5 3 0 0 3 3 3 1 PCI domain RPN7 PF10602.7 MSTRG.20912.1_3 - 0.00059 19.4 0.4 0.0013 18.2 0.4 1.6 1 0 0 1 1 1 1 26S proteasome subunit RPN7 TPR_7 PF13176.4 MSTRG.20912.1_3 - 0.0092 15.8 0.8 0.72 9.9 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.20912.1_3 - 0.014 15.5 0.8 1.9 8.7 0.1 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.20912.1_3 - 0.024 15.3 3.4 5.7 7.9 0.1 4.2 3 1 1 4 4 4 0 Tetratricopeptide repeat DUF669 PF05037.11 MSTRG.20912.1_3 - 0.088 12.8 0.2 0.26 11.3 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF669) Pkinase_Tyr PF07714.15 MSTRG.8974.1_2 - 2.9e-35 121.7 0.0 4.1e-35 121.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.8974.1_2 - 1.3e-33 116.4 0.0 1.9e-33 115.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain TGF_beta_GS PF08515.10 MSTRG.8974.1_2 - 4.4e-17 61.1 0.4 8.3e-17 60.2 0.4 1.5 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif FTA2 PF13095.4 MSTRG.8974.1_2 - 0.12 11.9 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 PRY PF13765.4 MSTRG.7553.1_2 - 6.4e-11 41.6 0.1 1.6e-10 40.3 0.1 1.7 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 MSTRG.7553.1_2 - 0.0004 20.4 0.2 0.00061 19.8 0.2 1.3 1 0 0 1 1 1 1 SPRY domain UPF0693 PF16088.3 MSTRG.14543.2_3 - 0.013 15.6 0.0 0.018 15.1 0.0 1.1 1 0 0 1 1 1 0 UPF0693 family Collagen PF01391.16 MSTRG.17144.1_2 - 1.5e-157 511.3 716.4 1.6e-08 34.1 21.6 23.3 5 1 14 19 19 19 11 Collagen triple helix repeat (20 copies) COLFI PF01410.16 MSTRG.17144.1_2 - 4.7e-94 313.9 0.0 6.5e-94 313.4 0.0 1.2 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Laminin_G_3 PF13385.4 MSTRG.17144.1_2 - 5.3e-06 26.5 0.0 1.2e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.22 MSTRG.17144.1_2 - 1.6e-05 25.4 0.0 3e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.21 MSTRG.17144.1_2 - 0.067 13.3 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Laminin G domain CH PF00307.29 MSTRG.12355.4_1 - 2.9e-06 27.3 0.0 4.3e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain Pilt PF15453.4 MSTRG.26260.2_3 - 9.9e-36 123.8 0.6 9.9e-36 123.8 0.6 1.9 2 1 0 2 2 1 1 Protein incorporated later into Tight Junctions IFT57 PF10498.7 MSTRG.26260.2_3 - 0.013 14.4 6.0 0.017 14.0 6.0 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Spc7 PF08317.9 MSTRG.26260.2_3 - 0.019 13.7 0.7 0.019 13.7 0.7 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein CALCOCO1 PF07888.9 MSTRG.26260.2_3 - 0.037 12.5 12.4 0.053 12.0 12.4 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF3584 PF12128.6 MSTRG.26260.2_3 - 0.04 11.3 8.0 0.052 10.9 8.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Tai4 PF16695.3 MSTRG.26260.2_3 - 0.045 14.1 0.2 0.084 13.3 0.2 1.4 1 0 0 1 1 1 0 Type VI secretion system (T6SS), amidase immunity protein OmpH PF03938.12 MSTRG.26260.2_3 - 0.072 13.0 9.6 0.16 11.8 9.5 1.5 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF2407_C PF13373.4 MSTRG.26260.2_3 - 0.2 11.7 0.7 0.35 10.9 0.7 1.3 1 0 0 1 1 1 0 DUF2407 C-terminal domain IncA PF04156.12 MSTRG.26260.2_3 - 0.24 11.0 14.2 4.4 6.9 14.2 2.1 1 1 0 1 1 1 0 IncA protein ATG16 PF08614.9 MSTRG.26260.2_3 - 0.25 11.4 13.8 0.64 10.0 13.8 1.6 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Med9 PF07544.11 MSTRG.26260.2_3 - 0.36 10.8 6.2 0.19 11.7 0.6 2.5 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF4200 PF13863.4 MSTRG.26260.2_3 - 0.38 11.0 12.8 0.74 10.1 12.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Fez1 PF06818.13 MSTRG.26260.2_3 - 0.41 10.9 12.9 0.023 15.0 3.0 2.2 1 1 1 2 2 2 0 Fez1 Mnd1 PF03962.13 MSTRG.26260.2_3 - 0.5 10.1 6.0 0.81 9.4 6.0 1.4 1 0 0 1 1 1 0 Mnd1 family DUF342 PF03961.11 MSTRG.26260.2_3 - 0.5 8.8 4.5 0.68 8.3 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Exonuc_VII_L PF02601.13 MSTRG.26260.2_3 - 0.57 9.6 5.8 0.79 9.1 5.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Lebercilin PF15619.4 MSTRG.26260.2_3 - 0.61 9.6 17.4 2 7.9 16.5 2.1 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Fzo_mitofusin PF04799.11 MSTRG.26260.2_3 - 0.65 9.4 5.7 0.56 9.6 3.2 1.9 1 1 1 2 2 2 0 fzo-like conserved region UPF0242 PF06785.9 MSTRG.26260.2_3 - 0.67 8.5 6.4 1 7.9 6.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) Jnk-SapK_ap_N PF09744.7 MSTRG.26260.2_3 - 1.2 9.2 16.6 0.54 10.3 12.0 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Med30 PF11315.6 MSTRG.26260.2_3 - 1.4 9.0 8.5 1.7 8.7 4.4 2.2 1 1 1 2 2 2 0 Mediator complex subunit 30 TPR_MLP1_2 PF07926.10 MSTRG.26260.2_3 - 1.6 8.7 10.6 4 7.4 10.6 1.7 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.4 MSTRG.26260.2_3 - 1.7 7.8 4.1 2.6 7.2 4.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMF_TATA_bd PF12325.6 MSTRG.26260.2_3 - 1.8 8.6 12.7 0.22 11.6 4.7 2.5 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF2951 PF11166.6 MSTRG.26260.2_3 - 2.2 8.4 5.1 5 7.3 5.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) V_ATPase_I PF01496.17 MSTRG.26260.2_3 - 2.3 5.9 4.0 2.9 5.5 4.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fib_alpha PF08702.8 MSTRG.26260.2_3 - 2.6 8.1 9.9 0.75 9.8 6.1 2.0 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family ADIP PF11559.6 MSTRG.26260.2_3 - 2.9 7.8 15.2 1.3 9.0 8.0 2.6 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding APG6 PF04111.10 MSTRG.26260.2_3 - 3.3 6.9 11.5 4.7 6.4 11.5 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 BRE1 PF08647.9 MSTRG.26260.2_3 - 3.8 7.5 14.1 32 4.5 4.4 2.3 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Cep57_MT_bd PF06657.11 MSTRG.26260.2_3 - 6.4 7.2 12.3 0.18 12.1 3.3 2.9 2 1 2 4 4 3 0 Centrosome microtubule-binding domain of Cep57 CENP-Q PF13094.4 MSTRG.26260.2_3 - 6.6 6.8 14.0 16 5.5 13.8 1.9 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Patched PF02460.16 MSTRG.29663.1_2 - 2.2e-27 95.4 14.2 2.7e-27 95.1 14.2 1.1 1 0 0 1 1 1 1 Patched family PBAN PF05874.9 MSTRG.29663.1_2 - 0.042 13.6 0.0 0.067 12.9 0.0 1.2 1 0 0 1 1 1 0 Pheromone biosynthesis activating neuropeptide (PBAN) bZIP_1 PF00170.19 MSTRG.27400.2_1 - 1.2e-11 44.4 13.5 2.5e-11 43.4 13.5 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 MSTRG.27400.2_1 - 0.00069 19.5 15.8 0.00069 19.5 15.8 1.7 2 0 0 2 2 2 1 Basic region leucine zipper Nop53 PF07767.9 MSTRG.27400.2_1 - 0.0042 16.4 6.9 0.0063 15.9 6.9 1.2 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) IncA PF04156.12 MSTRG.27400.2_1 - 0.023 14.3 2.2 0.035 13.8 2.2 1.2 1 0 0 1 1 1 0 IncA protein Ndc1_Nup PF09531.8 MSTRG.27400.2_1 - 2.8 6.4 5.3 4 5.8 5.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup APG6 PF04111.10 MSTRG.27400.2_1 - 3.9 6.6 6.5 5.7 6.1 6.5 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 NAAA-beta PF15508.4 MSTRG.13076.1_2 - 3.7e-11 43.0 0.6 7.8e-11 42.0 0.6 1.6 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase CBAH PF02275.16 MSTRG.13076.1_2 - 8.6e-08 32.0 0.0 2.4e-06 27.3 0.0 2.3 1 1 1 2 2 2 1 Linear amide C-N hydrolases, choloylglycine hydrolase family DUF1143 PF06608.9 MSTRG.13076.1_2 - 0.053 13.4 0.4 2.1 8.2 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1143) AAT PF03417.14 MSTRG.13076.1_2 - 0.13 11.8 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase RNase_PH PF01138.19 MSTRG.26252.1_1 - 6.7e-19 68.6 0.0 1.1e-18 67.8 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 PNPase PF03726.12 MSTRG.26252.1_1 - 5e-09 36.4 0.2 8.6e-09 35.7 0.2 1.4 1 0 0 1 1 1 1 Polyribonucleotide nucleotidyltransferase, RNA binding domain RNase_PH_C PF03725.13 MSTRG.26252.1_1 - 2.6e-08 33.6 0.1 4.9e-08 32.7 0.1 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 DUF3136 PF11334.6 MSTRG.26252.1_1 - 0.049 13.3 0.2 1.6 8.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3136) RST PF12174.6 MSTRG.26252.1_1 - 0.1 12.4 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 RCD1-SRO-TAF4 (RST) plant domain Ribosomal_L7Ae PF01248.24 MSTRG.9038.1_3 - 4.3e-10 39.0 0.0 6.7e-10 38.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family BAR PF03114.16 MSTRG.20924.1_1 - 9.5e-69 231.5 4.9 1.4e-68 231.0 4.9 1.2 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.4 MSTRG.20924.1_1 - 5.6e-10 38.8 0.1 1.2e-09 37.7 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.20924.1_1 - 6.3e-07 28.8 0.0 1e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 SH3 domain BAR_2 PF10455.7 MSTRG.20924.1_1 - 4.5e-06 25.9 3.1 8.8e-06 24.9 3.1 1.4 1 1 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking SH3_2 PF07653.15 MSTRG.20924.1_1 - 7.8e-05 22.2 0.0 0.00013 21.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain BAR_3 PF16746.3 MSTRG.20924.1_1 - 0.0002 21.0 0.5 0.00038 20.1 0.5 1.4 1 0 0 1 1 1 1 BAR domain of APPL family zf-RING_11 PF17123.3 MSTRG.20924.1_1 - 0.19 11.4 1.3 0.5 10.0 1.3 1.7 1 0 0 1 1 1 0 RING-like zinc finger bZIP_Maf PF03131.15 MSTRG.20924.1_1 - 1.8 9.0 8.6 0.1 13.0 2.6 2.1 3 0 0 3 3 3 0 bZIP Maf transcription factor DegS PF05384.9 MSTRG.23300.1_1 - 0.076 12.4 0.5 0.12 11.7 0.5 1.2 1 0 0 1 1 1 0 Sensor protein DegS DUF733 PF05306.9 MSTRG.23300.1_1 - 0.16 12.2 2.0 0.23 11.7 1.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF733) DUF4761 PF15958.3 MSTRG.28293.1_3 - 0.076 13.0 0.0 0.089 12.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4761) Ephrin_lbd PF01404.17 MSTRG.2782.1_1 - 2.2e-71 239.4 0.2 3.9e-71 238.6 0.2 1.4 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain fn3 PF00041.19 MSTRG.2782.1_1 - 2.4e-26 91.7 5.2 1.7e-13 50.6 0.1 3.2 3 0 0 3 3 3 2 Fibronectin type III domain Ephrin_rec_like PF07699.11 MSTRG.2782.1_1 - 1.4e-05 24.6 6.0 1.4e-05 24.6 6.0 3.3 2 2 1 3 3 3 1 Putative ephrin-receptor like SusE PF14292.4 MSTRG.2782.1_1 - 2.7e-05 24.4 0.4 0.28 11.5 0.0 2.6 2 0 0 2 2 2 2 SusE outer membrane protein Tissue_fac PF01108.15 MSTRG.2782.1_1 - 0.012 15.3 0.6 0.18 11.5 0.1 2.6 2 0 0 2 2 2 0 Tissue factor DUF2318 PF10080.7 MSTRG.2782.1_1 - 0.024 14.6 2.5 0.024 14.6 2.5 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) Pur_ac_phosph_N PF16656.3 MSTRG.2782.1_1 - 0.27 11.7 3.5 0.42 11.1 0.6 2.6 2 1 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain hEGF PF12661.5 MSTRG.2782.1_1 - 0.4 11.3 7.5 4.7 7.9 0.2 3.5 4 0 0 4 4 4 0 Human growth factor-like EGF EGF_2 PF07974.11 MSTRG.2782.1_1 - 0.77 10.1 12.3 0.89 9.9 1.0 3.5 3 0 0 3 3 3 0 EGF-like domain EGF_MSP1_1 PF12946.5 MSTRG.2782.1_1 - 2.4 8.1 7.2 1.2 9.2 0.9 2.7 2 0 0 2 2 2 0 MSP1 EGF domain 1 Phe_tRNA-synt_N PF02912.16 MSTRG.19320.1_2 - 0.054 13.3 2.0 0.1 12.4 2.0 1.4 1 0 0 1 1 1 0 Aminoacyl tRNA synthetase class II, N-terminal domain WD40 PF00400.30 MSTRG.19902.1_3 - 4.4e-11 43.0 6.2 0.019 15.7 0.1 5.8 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.19902.1_3 - 4e-07 30.1 0.0 0.002 18.3 0.0 4.0 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 MSTRG.19902.1_3 - 0.014 14.2 0.0 0.97 8.2 0.0 2.5 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.3 MSTRG.19902.1_3 - 0.029 13.6 0.0 0.042 13.0 0.0 1.2 1 0 0 1 1 1 0 WD40-like domain EF-hand_6 PF13405.4 MSTRG.23013.3_2 - 1.8e-09 36.7 0.1 0.0012 18.5 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.30 MSTRG.23013.3_2 - 3.4e-08 32.3 0.1 0.038 13.4 0.0 3.5 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.4 MSTRG.23013.3_2 - 1.4e-05 25.3 0.0 0.013 15.8 0.0 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 MSTRG.23013.3_2 - 0.023 14.3 1.3 0.91 9.2 0.0 2.7 2 1 1 3 3 3 0 EF-hand domain pair EF-hand_9 PF14658.4 MSTRG.23013.3_2 - 0.074 13.3 0.0 4.1 7.7 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain DUF4460 PF14687.4 MSTRG.13425.1_3 - 5.9e-37 126.0 0.0 1.1e-36 125.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4460) DUF4461 PF14688.4 MSTRG.13425.1_3 - 8e-09 35.6 0.9 1.4e-08 34.8 0.5 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4461) Carboxyl_trans PF01039.20 MSTRG.26089.2_1 - 1.5e-26 93.0 0.0 2e-26 92.6 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain SPARC_Ca_bdg PF10591.7 MSTRG.11539.1_1 - 3.6e-40 136.7 0.3 3.6e-40 136.7 0.3 2.3 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Kazal_1 PF00050.19 MSTRG.11539.1_1 - 1e-11 44.5 6.2 1e-11 44.5 6.2 2.1 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.13 MSTRG.11539.1_1 - 1.6e-10 40.9 3.8 4.6e-10 39.4 3.8 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain FOLN PF09289.8 MSTRG.11539.1_1 - 1e-09 38.3 7.3 1e-09 38.3 7.3 2.1 2 0 0 2 2 2 1 Follistatin/Osteonectin-like EGF domain EF-hand_1 PF00036.30 MSTRG.11539.1_1 - 0.074 12.5 0.1 0.28 10.7 0.0 2.0 2 0 0 2 2 2 0 EF hand DUF3694 PF12473.6 MSTRG.8616.1_1 - 1.8e-33 116.2 0.0 5.1e-33 114.7 0.0 1.8 1 0 0 1 1 1 1 Kinesin protein PID PF00640.21 MSTRG.8616.1_1 - 1.7e-05 24.8 0.0 4.7e-05 23.3 0.0 1.8 1 1 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 MSTRG.8616.1_1 - 0.034 14.2 0.0 0.062 13.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotyrosine-binding domain DUF4159 PF13709.4 MSTRG.8616.1_1 - 0.12 11.7 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4159) YTH PF04146.13 MSTRG.16704.3_3 - 1.3e-40 137.8 0.0 1.9e-40 137.2 0.0 1.3 1 0 0 1 1 1 1 YT521-B-like domain DSPc PF00782.18 MSTRG.25598.1_3 - 7.5e-39 132.5 0.0 1.2e-38 131.7 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.18 MSTRG.25598.1_3 - 1.5e-11 44.6 0.0 5.2e-11 42.9 0.0 1.9 2 0 0 2 2 2 1 Rhodanese-like domain PTPlike_phytase PF14566.4 MSTRG.25598.1_3 - 8.4e-05 22.6 0.0 0.00016 21.7 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.25 MSTRG.25598.1_3 - 0.0097 15.4 0.0 0.018 14.5 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.10 MSTRG.25598.1_3 - 0.011 15.9 0.0 0.075 13.2 0.0 2.2 2 0 0 2 2 2 0 Rit1 DUSP-like domain TPR_10 PF13374.4 MSTRG.14776.2_1 - 7.2e-57 187.7 13.4 1.6e-15 56.3 0.0 7.0 7 0 0 7 7 6 6 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.14776.2_1 - 1.7e-52 175.5 14.6 1e-19 70.5 1.4 5.4 4 1 2 6 6 5 5 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.14776.2_1 - 2.7e-24 83.2 15.1 9e-06 25.2 0.0 7.5 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.14776.2_1 - 7.3e-23 79.3 29.8 2.6e-07 30.0 0.5 6.7 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.14776.2_1 - 7.5e-16 56.8 26.7 0.0013 18.6 0.4 6.6 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.14776.2_1 - 2.4e-12 45.9 24.3 0.0028 17.6 0.1 6.9 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.14776.2_1 - 4.6e-12 46.3 2.8 0.0073 16.8 1.2 5.6 2 1 3 5 5 5 4 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.14776.2_1 - 2.1e-08 34.4 6.9 0.012 16.0 0.6 4.1 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.14776.2_1 - 1.3e-07 31.4 9.9 0.48 10.8 0.1 6.1 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.14776.2_1 - 5.7e-06 26.6 7.5 11 7.0 0.2 6.6 4 1 3 7 7 6 0 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.14776.2_1 - 2e-05 24.6 9.1 0.0058 16.7 0.5 3.7 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.12 MSTRG.14776.2_1 - 0.00023 21.3 1.9 3.4 8.4 0.2 5.3 6 0 0 6 6 5 1 Tetratricopeptide repeat PPR PF01535.18 MSTRG.14776.2_1 - 0.00094 19.1 1.1 0.34 11.1 0.0 4.0 4 0 0 4 4 3 1 PPR repeat DUF627 PF04781.10 MSTRG.14776.2_1 - 0.0026 17.6 2.8 0.68 9.9 0.0 3.3 2 1 1 3 3 3 2 Protein of unknown function (DUF627) JIP_LZII PF16471.3 MSTRG.14776.2_1 - 0.0049 16.9 4.3 0.0049 16.9 4.3 2.2 2 1 0 2 2 2 1 JNK-interacting protein leucine zipper II PPR_2 PF13041.4 MSTRG.14776.2_1 - 0.19 11.8 0.8 8 6.6 0.1 3.1 3 0 0 3 3 3 0 PPR repeat family COG2 PF06148.9 MSTRG.14776.2_1 - 0.45 10.5 6.0 0.59 10.1 4.7 1.8 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 TPR_6 PF13174.4 MSTRG.14776.2_1 - 2.7 8.7 7.2 31 5.4 0.1 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF342 PF03961.11 MSTRG.14776.2_1 - 7.2 4.9 8.5 12 4.2 8.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) TPR_3 PF07720.10 MSTRG.14776.2_1 - 7.8 6.5 11.3 16 5.5 0.8 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Neuregulin PF02158.13 MSTRG.2296.1_1 - 3.4e-64 217.6 21.6 3.5e-46 158.3 4.1 2.0 1 1 1 2 2 2 2 Neuregulin family Cyt_b-c1_8 PF10890.6 MSTRG.2296.1_1 - 0.06 13.6 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 Cytochrome b-c1 complex subunit 8 TMEM132D_C PF15706.3 MSTRG.2296.1_1 - 0.094 12.4 0.1 0.21 11.2 0.1 1.6 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term SVIP PF15811.3 MSTRG.2296.1_1 - 0.11 12.8 2.5 0.3 11.4 2.2 2.0 2 0 0 2 2 2 0 Small VCP/p97-interacting protein SIT PF15330.4 MSTRG.2296.1_1 - 0.14 12.5 2.1 0.14 12.5 0.5 1.9 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT MLANA PF14991.4 MSTRG.2296.1_1 - 0.35 11.0 3.6 0.18 12.0 0.3 2.2 2 1 1 3 3 3 0 Protein melan-A RhoGAP PF00620.25 MSTRG.13773.1_1 - 7.1e-41 139.4 0.4 1.8e-40 138.1 0.0 1.8 2 0 0 2 2 2 1 RhoGAP domain C1_1 PF00130.20 MSTRG.13773.1_1 - 0.00038 20.1 6.5 0.00038 20.1 6.5 2.1 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) I-set PF07679.14 MSTRG.236.1_1 - 2.8e-124 405.4 0.0 4.5e-18 65.0 0.0 8.2 8 0 0 8 8 8 8 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.236.1_1 - 9.9e-73 240.6 0.0 1e-11 45.2 0.0 8.3 8 0 0 8 8 8 8 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.236.1_1 - 2.3e-33 114.2 0.0 4.1e-05 23.7 0.0 8.1 8 0 0 8 8 8 6 Immunoglobulin domain ig PF00047.23 MSTRG.236.1_1 - 3.1e-33 113.7 0.0 8.3e-05 22.5 0.0 8.4 8 0 0 8 8 8 7 Immunoglobulin domain C2-set_2 PF08205.10 MSTRG.236.1_1 - 5.4e-12 45.5 0.0 0.0066 16.4 0.0 6.9 7 0 0 7 7 7 1 CD80-like C2-set immunoglobulin domain V-set PF07686.15 MSTRG.236.1_1 - 3.6e-11 43.1 0.4 8.8 6.4 0.0 9.1 8 3 2 10 10 10 1 Immunoglobulin V-set domain BiPBP_C PF06832.10 MSTRG.236.1_1 - 1.8e-08 34.2 0.0 2.6 8.0 0.0 6.9 7 0 0 7 7 7 2 Penicillin-Binding Protein C-terminus Family C1-set PF07654.13 MSTRG.236.1_1 - 2.9e-07 30.7 0.5 0.65 10.4 0.1 5.9 7 0 0 7 7 6 2 Immunoglobulin C1-set domain Izumo-Ig PF16706.3 MSTRG.236.1_1 - 0.031 14.2 0.4 25 4.9 0.1 3.9 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain DUF4198 PF10670.7 MSTRG.236.1_1 - 0.049 13.9 0.1 3.3 7.9 0.0 3.8 5 0 0 5 5 5 0 Domain of unknown function (DUF4198) DUF2914 PF11141.6 MSTRG.236.1_1 - 0.13 11.9 2.2 0.97 9.1 0.1 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF2914) Oxysterol_BP PF01237.16 MSTRG.3158.1_1 - 1.2e-149 498.1 0.9 1.5e-149 497.8 0.9 1.1 1 0 0 1 1 1 1 Oxysterol-binding protein NHL PF01436.19 MSTRG.15444.1_1 - 2.4e-31 106.1 5.4 1.1e-06 28.3 0.1 7.9 7 1 0 7 7 7 4 NHL repeat Thioredoxin_8 PF13905.4 MSTRG.15444.1_1 - 2.5e-13 50.0 0.0 5.9e-13 48.8 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like SGL PF08450.10 MSTRG.15444.1_1 - 1.7e-06 27.7 0.0 0.00085 18.8 0.0 2.8 2 1 0 2 2 2 2 SMP-30/Gluconolaconase/LRE-like region Arylesterase PF01731.18 MSTRG.15444.1_1 - 0.00021 21.3 0.0 0.58 10.3 0.0 3.2 3 0 0 3 3 3 2 Arylesterase Thioredoxin PF00085.18 MSTRG.15444.1_1 - 0.02 14.7 0.0 0.071 12.9 0.0 1.8 2 0 0 2 2 2 0 Thioredoxin LVIVD PF08309.9 MSTRG.15444.1_1 - 0.032 13.4 0.5 0.91 8.8 0.0 2.9 3 0 0 3 3 3 0 LVIVD repeat PHD_4 PF16866.3 MSTRG.5317.1_3 - 3e-25 88.0 8.0 3e-25 88.0 8.0 2.4 2 0 0 2 2 2 1 PHD-finger zf-CXXC PF02008.18 MSTRG.5317.1_3 - 2.4e-13 49.7 22.1 2.4e-13 49.7 22.1 3.1 2 0 0 2 2 2 1 CXXC zinc finger domain F-box PF00646.31 MSTRG.5317.1_3 - 0.00034 20.3 6.0 0.00034 20.3 6.0 2.7 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.5 MSTRG.5317.1_3 - 0.00048 19.8 10.8 0.0012 18.5 10.8 1.7 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.5 MSTRG.5317.1_3 - 0.002 18.3 2.8 0.088 13.1 0.0 3.7 4 0 0 4 4 4 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 MSTRG.5317.1_3 - 0.19 11.7 10.1 51 4.2 0.1 5.6 6 0 0 6 6 6 0 Leucine Rich repeat LRR_1 PF00560.31 MSTRG.5317.1_3 - 0.2 12.1 1.7 1.1e+02 3.8 0.0 4.9 4 0 0 4 4 4 0 Leucine Rich Repeat Rrp15p PF07890.10 MSTRG.13403.2_3 - 2.6e-31 108.5 13.7 4.1e-31 107.8 13.7 1.3 1 0 0 1 1 1 1 Rrp15p RabGAP-TBC PF00566.16 MSTRG.17160.1_3 - 1.1e-28 100.3 2.5 1.3e-28 100.0 1.4 1.7 2 0 0 2 2 2 1 Rab-GTPase-TBC domain ADK PF00406.20 MSTRG.17160.1_3 - 0.0069 16.4 0.8 0.24 11.4 0.0 2.2 2 0 0 2 2 2 2 Adenylate kinase Calsarcin PF05556.9 MSTRG.389.1_1 - 1.4e-77 260.3 1.8 1.8e-77 259.9 1.8 1.1 1 0 0 1 1 1 1 Calcineurin-binding protein (Calsarcin) JTB PF05439.10 MSTRG.25728.1_2 - 4.5e-35 119.9 3.5 7.2e-35 119.2 3.5 1.3 1 0 0 1 1 1 1 Jumping translocation breakpoint protein (JTB) Ank_2 PF12796.5 MSTRG.10948.2_2 - 1.5e-24 86.2 5.4 7.6e-09 35.9 0.2 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) KN_motif PF12075.6 MSTRG.10948.2_2 - 1.6e-22 78.8 0.8 2.9e-22 78.0 0.8 1.4 1 0 0 1 1 1 1 KN motif Ank_5 PF13857.4 MSTRG.10948.2_2 - 2.6e-21 75.2 3.6 3.1e-12 46.4 0.1 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.10948.2_2 - 5e-18 63.2 3.9 3.7e-05 23.7 0.0 4.9 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.4 MSTRG.10948.2_2 - 1.9e-17 63.2 5.6 3.1e-08 33.9 0.1 4.5 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.10948.2_2 - 4.3e-16 58.4 10.1 0.00032 20.9 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat K-box PF01486.15 MSTRG.10948.2_2 - 2.1 8.5 5.1 0.82 9.8 1.0 2.2 2 0 0 2 2 2 0 K-box region Sec1 PF00995.21 MSTRG.4228.2_1 - 3e-22 79.4 0.0 4.2e-22 79.0 0.0 1.1 1 0 0 1 1 1 1 Sec1 family Sec1 PF00995.21 MSTRG.4228.2_2 - 2.9e-89 300.7 10.7 3.9e-89 300.3 10.7 1.1 1 0 0 1 1 1 1 Sec1 family Myosin_head PF00063.19 MSTRG.25066.1_2 - 2.1e-273 908.5 5.1 4e-273 907.6 5.1 1.5 1 0 0 1 1 1 1 Myosin head (motor domain) DIL PF01843.17 MSTRG.25066.1_2 - 1.1e-27 96.2 2.3 1.1e-27 96.2 2.3 3.9 3 0 0 3 3 3 1 DIL domain IQ PF00612.25 MSTRG.25066.1_2 - 9.6e-19 65.2 52.5 0.00047 19.6 2.1 7.5 8 0 0 8 8 8 6 IQ calmodulin-binding motif Atg14 PF10186.7 MSTRG.25066.1_2 - 0.00082 18.4 7.6 0.00082 18.4 7.6 4.5 3 1 1 4 4 4 1 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_22 PF13401.4 MSTRG.25066.1_2 - 0.0033 17.6 5.0 0.081 13.1 0.0 3.4 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.4 MSTRG.25066.1_2 - 0.062 13.5 5.6 0.068 13.4 0.0 3.4 3 0 0 3 3 3 0 AAA ATPase domain HMG_box_5 PF14887.4 MSTRG.25066.1_2 - 1.3 8.9 5.3 5.6 6.9 0.6 3.0 2 0 0 2 2 2 0 HMG (high mobility group) box 5 Mito_carr PF00153.25 MSTRG.9832.1_3 - 1e-48 163.1 6.3 9.9e-16 57.3 0.4 3.2 2 1 1 3 3 3 3 Mitochondrial carrier protein WD40 PF00400.30 MSTRG.16210.1_2 - 1.8e-30 104.4 30.9 5.9e-08 33.1 3.5 7.7 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.16210.1_2 - 1.6e-10 41.0 3.0 0.0032 17.6 0.0 5.2 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.8 MSTRG.16210.1_2 - 9.5e-09 34.8 0.0 2.1e-08 33.7 0.0 1.7 1 0 0 1 1 1 1 HIRA B motif PD40 PF07676.10 MSTRG.16210.1_2 - 0.003 17.3 0.0 2.2 8.2 0.0 4.7 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat TFIIIC_delta PF12657.5 MSTRG.16210.1_2 - 0.034 13.9 0.9 0.22 11.3 0.1 2.8 2 1 0 2 2 2 0 Transcription factor IIIC subunit delta N-term WD40_like PF17005.3 MSTRG.16210.1_2 - 0.049 12.8 0.0 0.63 9.2 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain GST_N_3 PF13417.4 MSTRG.8533.1_2 - 2.9e-13 49.9 0.0 2e-12 47.2 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 MSTRG.8533.1_2 - 2e-11 43.9 0.0 4e-10 39.7 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.18 MSTRG.8533.1_2 - 8.1e-10 38.8 0.0 1.5e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Tom37 PF10568.7 MSTRG.8533.1_2 - 0.0027 17.8 0.0 0.0043 17.1 0.0 1.3 1 1 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.2 MSTRG.8533.1_2 - 0.0066 17.1 0.0 0.0088 16.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain Pkinase_Tyr PF07714.15 MSTRG.16444.1_3 - 2.8e-90 302.0 0.0 4.3e-90 301.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Focal_AT PF03623.11 MSTRG.16444.1_3 - 3.7e-52 175.6 7.6 3.7e-52 175.6 7.6 1.8 2 0 0 2 2 2 1 Focal adhesion targeting region Pkinase PF00069.23 MSTRG.16444.1_3 - 3.9e-43 147.6 0.0 8.5e-43 146.5 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain FERM_M PF00373.16 MSTRG.16444.1_3 - 6.4e-15 55.5 1.1 1.7e-14 54.1 1.1 1.8 1 0 0 1 1 1 1 FERM central domain Baculo_PEP_C PF04513.10 MSTRG.16444.1_3 - 0.11 12.4 1.0 0.27 11.2 1.0 1.7 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus ApoL PF05461.9 MSTRG.15654.2_2 - 3.3e-32 112.0 7.3 6.1e-32 111.1 7.3 1.4 1 0 0 1 1 1 1 Apolipoprotein L p47_phox_C PF08944.9 MSTRG.15654.2_2 - 1.2 8.4 9.6 0.23 10.8 2.2 2.7 2 0 0 2 2 2 0 NADPH oxidase subunit p47Phox, C terminal domain Evr1_Alr PF04777.11 MSTRG.4035.1_1 - 6.7e-28 97.0 0.9 6.7e-28 97.0 0.9 2.1 2 0 0 2 2 2 1 Erv1 / Alr family EST1_DNA_bind PF10373.7 MSTRG.10418.2_3 - 7.2e-48 163.4 0.5 1e-47 162.8 0.5 1.2 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain EST1 PF10374.7 MSTRG.10418.2_3 - 3.6e-07 30.8 1.9 4.3e-07 30.5 0.1 2.2 2 0 0 2 2 2 1 Telomerase activating protein Est1 TPR_7 PF13176.4 MSTRG.10418.2_3 - 0.0091 15.8 0.0 0.36 10.8 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.10418.2_3 - 0.075 13.0 0.0 0.2 11.7 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TROVE PF05731.9 MSTRG.12720.1_3 - 3.1e-08 32.9 0.0 4e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 TROVE domain VWA_2 PF13519.4 MSTRG.12720.1_3 - 0.018 15.5 0.1 0.024 15.1 0.1 1.2 1 0 0 1 1 1 0 von Willebrand factor type A domain Herpes_U15 PF05613.9 MSTRG.12720.1_3 - 0.094 13.3 0.1 0.22 12.1 0.1 1.6 1 1 0 1 1 1 0 Human herpesvirus U15 protein DDT PF02791.15 MSTRG.629.2_2 - 0.17 12.1 0.1 0.29 11.4 0.1 1.3 1 0 0 1 1 1 0 DDT domain EF-hand_6 PF13405.4 MSTRG.629.2_3 - 1.4e-11 43.2 0.0 0.064 13.1 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.30 MSTRG.629.2_3 - 1.9e-11 42.5 0.4 0.0054 16.1 0.0 4.8 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.4 MSTRG.629.2_3 - 5.7e-08 33.0 0.8 0.086 13.2 0.0 3.3 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.4 MSTRG.629.2_3 - 7.9e-06 25.4 1.7 4e-05 23.1 0.1 2.9 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.629.2_3 - 0.0039 16.5 0.0 1.8 8.1 0.0 3.4 3 0 0 3 3 3 1 EF hand Elf-1_N PF12310.6 MSTRG.10247.1_1 - 5.3e-34 117.0 2.9 9.3e-34 116.2 2.9 1.4 1 0 0 1 1 1 1 Transcription factor protein N terminal Ets PF00178.20 MSTRG.10247.1_1 - 7.6e-34 115.9 1.4 1.4e-33 115.1 1.4 1.5 1 0 0 1 1 1 1 Ets-domain PH_13 PF16652.3 MSTRG.26341.1_3 - 1.7e-72 242.3 0.1 3.7e-72 241.2 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.18 MSTRG.26341.1_3 - 4.2e-46 157.3 2.3 1.1e-45 156.0 1.2 2.0 2 0 0 2 2 2 1 RhoGEF domain C2 PF00168.28 MSTRG.26341.1_3 - 1.4e-21 76.6 0.0 3.3e-21 75.4 0.0 1.6 1 0 0 1 1 1 1 C2 domain PH PF00169.27 MSTRG.26341.1_3 - 0.00032 21.0 0.0 0.00079 19.8 0.0 1.7 1 0 0 1 1 1 1 PH domain IL34 PF15036.4 MSTRG.26341.1_3 - 0.034 14.1 0.1 5.3 6.9 0.0 3.1 4 0 0 4 4 4 0 Interleukin 34 WD40 PF00400.30 MSTRG.1283.1_2 - 0.011 16.4 0.6 0.54 11.1 0.0 3.3 3 0 0 3 3 3 0 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.1283.1_2 - 0.032 14.4 0.0 0.11 12.7 0.0 2.0 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain CBM_21 PF03370.11 MSTRG.23163.3_3 - 2.5e-31 108.0 0.2 3.8e-31 107.4 0.2 1.2 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.3 MSTRG.23163.3_3 - 2.1e-13 50.5 0.4 4e-13 49.6 0.4 1.4 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) Helicase_C PF00271.29 MSTRG.29033.1_2 - 7.6e-19 68.0 0.4 1.4e-18 67.1 0.4 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PRK PF00485.16 MSTRG.29033.1_2 - 0.02 14.5 0.0 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Methuselah_N PF06652.10 MSTRG.19338.1_1 - 4 7.2 7.7 5.5 6.7 7.7 1.2 1 0 0 1 1 1 0 Methuselah N-terminus Gal-bind_lectin PF00337.20 MSTRG.19338.1_2 - 0.0033 16.8 0.0 0.0046 16.4 0.0 1.2 1 0 0 1 1 1 1 Galactoside-binding lectin GDA1_CD39 PF01150.15 MSTRG.27466.1_3 - 7.7e-100 334.4 0.0 1.1e-99 333.9 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family EF-hand_1 PF00036.30 MSTRG.5772.1_2 - 7.7e-17 59.4 14.3 0.00052 19.2 0.0 6.6 7 0 0 7 7 7 5 EF hand EF-hand_7 PF13499.4 MSTRG.5772.1_2 - 1.5e-12 47.7 18.7 4.2e-06 27.0 0.2 5.0 2 2 4 6 6 6 6 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.5772.1_2 - 1.7e-12 46.1 4.6 0.045 13.6 0.1 5.3 6 0 0 6 6 6 4 EF-hand domain EF-hand_5 PF13202.4 MSTRG.5772.1_2 - 3.4e-09 35.7 2.0 0.15 11.5 0.0 4.9 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.4 MSTRG.5772.1_2 - 8e-06 25.4 4.7 0.067 12.8 0.0 4.3 5 0 0 5 5 5 2 EF-hand domain pair DsrC PF04358.11 MSTRG.5772.1_2 - 0.011 16.0 0.0 0.036 14.4 0.0 1.9 1 0 0 1 1 1 0 DsrC like protein Pex14_N PF04695.11 MSTRG.5772.1_2 - 0.028 15.0 0.2 0.056 14.0 0.2 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SPARC_Ca_bdg PF10591.7 MSTRG.5772.1_2 - 1 9.6 18.3 1.2 9.3 2.6 3.6 1 1 2 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region DBC1 PF14443.4 MSTRG.26205.1_2 - 1.4e-50 170.3 0.0 1.4e-50 170.3 0.0 2.4 2 0 0 2 2 2 1 DBC1 S1-like PF14444.4 MSTRG.26205.1_2 - 4.1e-29 100.3 0.8 7.3e-29 99.5 0.8 1.4 1 0 0 1 1 1 1 S1-like SAP PF02037.25 MSTRG.26205.1_2 - 1.9e-08 33.8 1.4 4.1e-08 32.7 1.4 1.6 1 0 0 1 1 1 1 SAP domain SPX PF03105.17 MSTRG.26205.1_2 - 1.1e-06 28.8 0.0 1.1e-06 28.8 0.0 4.4 3 2 0 3 3 3 1 SPX domain Tautomerase_2 PF14552.4 MSTRG.26205.1_2 - 0.056 13.4 0.1 0.26 11.3 0.0 2.1 2 0 0 2 2 2 0 Tautomerase enzyme NTP_transferase PF00483.21 MSTRG.8402.4_2 - 1.3e-18 67.3 0.0 2.1e-18 66.7 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.5 MSTRG.8402.4_2 - 3e-13 50.3 0.0 4.8e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.22 MSTRG.8402.4_2 - 3.3e-06 26.5 4.6 0.21 11.3 1.4 4.0 2 1 3 5 5 5 4 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.3 MSTRG.8402.4_2 - 9.5e-05 20.6 1.6 0.00014 20.0 1.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) IspD PF01128.17 MSTRG.8402.4_2 - 0.036 13.7 0.0 0.067 12.8 0.0 1.4 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase TraI_2 PF07514.9 MSTRG.8402.4_2 - 0.082 11.7 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Putative helicase Fucokinase PF07959.10 MSTRG.8402.4_2 - 0.17 10.7 5.2 0.18 10.7 3.5 1.8 2 1 0 2 2 2 0 L-fucokinase TMEM154 PF15102.4 MSTRG.27542.1_1 - 1.3e-18 67.2 1.3 1.3e-18 67.2 1.3 1.6 1 1 0 1 1 1 1 TMEM154 protein family ASFV_J13L PF05568.9 MSTRG.27542.1_1 - 0.056 13.1 0.0 0.092 12.4 0.0 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein DUF3377 PF11857.6 MSTRG.27542.1_1 - 0.11 12.4 0.0 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) AftA_N PF12250.6 MSTRG.27542.1_1 - 0.17 10.5 0.0 0.25 9.9 0.0 1.1 1 0 0 1 1 1 0 Arabinofuranosyltransferase N terminal eIF3g PF12353.6 MSTRG.10927.2_1 - 1.2e-42 145.1 2.3 1.9e-42 144.5 2.3 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.20 MSTRG.10927.2_1 - 2.1e-19 68.9 0.0 5.5e-19 67.6 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CDV3 PF15359.4 MSTRG.10927.2_1 - 0.0017 18.7 3.4 0.014 15.7 3.4 2.2 1 1 0 1 1 1 1 Carnitine deficiency-associated protein 3 RRM_occluded PF16842.3 MSTRG.10927.2_1 - 0.013 15.3 0.0 0.029 14.1 0.0 1.6 1 0 0 1 1 1 0 Occluded RNA-recognition motif RNA_bind PF08675.9 MSTRG.10927.2_1 - 0.054 13.4 0.0 0.15 12.0 0.0 1.7 1 1 0 1 1 1 0 RNA binding domain Nup35_RRM_2 PF14605.4 MSTRG.10927.2_1 - 0.054 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Prismane PF03063.18 MSTRG.10927.2_1 - 0.17 10.4 0.2 0.23 10.0 0.2 1.2 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family NdhL PF10716.7 MSTRG.19212.2_2 - 0.14 12.0 3.5 5 7.0 0.5 2.2 1 1 1 2 2 2 0 NADH dehydrogenase transmembrane subunit ATE_C PF04377.13 MSTRG.14767.1_2 - 1.4e-51 174.5 1.5 2.9e-51 173.5 1.5 1.6 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.11 MSTRG.14767.1_2 - 4.2e-31 107.0 6.3 8.4e-31 106.1 6.3 1.5 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus RepA1_leader PF08048.10 MSTRG.18530.1_3 - 0.079 13.1 0.3 0.2 11.8 0.3 1.6 1 0 0 1 1 1 0 Tap RepA1 leader peptide Atrophin-1 PF03154.13 MSTRG.23146.1_1 - 4.6e-102 342.9 142.6 2.9e-54 184.7 85.1 3.0 2 1 1 3 3 3 2 Atrophin-1 family ELM2 PF01448.22 MSTRG.23146.1_1 - 8.5e-15 55.1 0.0 3e-14 53.4 0.0 2.1 1 0 0 1 1 1 1 ELM2 domain GATA PF00320.25 MSTRG.23146.1_1 - 2e-05 24.0 10.6 4.1e-05 23.0 10.6 1.6 1 0 0 1 1 1 1 GATA zinc finger Myb_DNA-bind_7 PF15963.3 MSTRG.23146.1_1 - 0.013 15.2 0.2 0.039 13.7 0.2 1.7 1 0 0 1 1 1 0 Myb DNA-binding like Myb_DNA-binding PF00249.29 MSTRG.23146.1_1 - 0.039 14.0 0.0 0.069 13.2 0.0 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain YEATS PF03366.14 MSTRG.15679.1_3 - 1.5e-25 88.9 0.9 3e-25 87.9 0.9 1.5 1 0 0 1 1 1 1 YEATS family SCAB_CC PF16712.3 MSTRG.15679.1_3 - 0.0063 16.1 2.9 0.012 15.2 2.9 1.4 1 0 0 1 1 1 1 Coiled-coil regions of plant-specific actin-binding protein RWD PF05773.20 MSTRG.13419.1_3 - 1e-25 90.2 1.5 1.9e-25 89.3 1.5 1.5 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.3 MSTRG.13419.1_3 - 2.3e-05 24.6 4.5 2.3e-05 24.6 4.5 2.8 2 1 1 3 3 3 1 DRG Family Regulatory Proteins, Tma46 Atrophin-1 PF03154.13 MSTRG.5490.1_1 - 0.00078 17.7 14.0 0.0014 16.9 14.0 1.3 1 0 0 1 1 1 1 Atrophin-1 family DUF3915 PF13054.4 MSTRG.5490.1_1 - 0.19 11.6 10.3 0.34 10.8 10.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) YTH PF04146.13 MSTRG.6597.1_1 - 5.5e-40 135.7 0.0 9e-40 135.0 0.0 1.3 1 0 0 1 1 1 1 YT521-B-like domain RNF111_N PF15303.4 MSTRG.19726.1_2 - 0.12 12.0 3.8 0.23 11.0 3.8 1.4 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase Arkadia N-terminus DUF544 PF04424.11 MSTRG.19726.1_3 - 1.5e-36 124.8 0.3 3e-36 123.8 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF544) RhoGEF PF00621.18 MSTRG.15983.2_2 - 2.2e-33 115.9 0.5 2.8e-33 115.6 0.5 1.1 1 0 0 1 1 1 1 RhoGEF domain SH3_9 PF14604.4 MSTRG.15983.2_2 - 2.2e-11 43.3 0.1 4.9e-11 42.2 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.15983.2_2 - 6.7e-11 41.5 2.1 1.1e-10 40.9 2.1 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.15983.2_2 - 1.5e-10 40.5 0.1 2.8e-10 39.6 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain Cor1 PF04803.10 MSTRG.15983.2_2 - 0.065 13.3 0.0 5 7.2 0.0 2.3 1 1 1 2 2 2 0 Cor1/Xlr/Xmr conserved region DUF3104 PF11302.6 MSTRG.15983.2_2 - 0.14 11.8 0.2 0.31 10.7 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) zf-H2C2_2 PF13465.4 MSTRG.17553.1_2 - 9.5e-39 130.0 40.6 1.7e-08 34.4 0.7 6.5 6 0 0 6 6 6 6 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.17553.1_2 - 4e-21 74.1 51.0 0.00011 22.3 2.0 7.2 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.17553.1_2 - 1.6e-14 53.2 50.1 0.0013 19.3 1.7 7.2 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.17553.1_2 - 5.2e-11 42.1 38.5 0.00086 19.1 0.1 7.4 7 0 0 7 7 7 5 C2H2-type zinc finger zf-met PF12874.5 MSTRG.17553.1_2 - 0.00073 19.7 39.9 0.038 14.2 0.3 6.5 6 0 0 6 6 6 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.17553.1_2 - 0.024 14.8 22.4 7 7.0 0.2 5.6 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 MSTRG.17553.1_2 - 5.3 7.1 17.8 0.7 9.9 0.8 4.8 3 1 2 5 5 5 0 Zinc ribbon domain Glyco_hydro_38 PF01074.20 MSTRG.11020.1_3 - 2.4e-84 283.0 0.4 3.6e-84 282.4 0.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.11 MSTRG.11020.1_3 - 1.3e-71 241.9 0.0 2.1e-71 241.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.9 MSTRG.11020.1_3 - 6.8e-30 103.1 0.0 3.8e-29 100.8 0.0 2.1 2 0 0 2 2 2 1 Alpha mannosidase middle domain zf-RING_11 PF17123.3 MSTRG.15374.3_1 - 0.014 15.0 0.0 0.03 13.9 0.0 1.6 1 0 0 1 1 1 0 RING-like zinc finger LIM PF00412.20 MSTRG.15374.3_2 - 1.8e-22 79.1 40.2 3.6e-11 43.0 11.1 3.7 4 0 0 4 4 4 3 LIM domain zf-RING_6 PF14835.4 MSTRG.15374.3_2 - 0.0051 16.5 4.9 0.0051 16.5 4.9 2.9 4 0 0 4 4 4 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.4 MSTRG.15374.3_2 - 0.0059 16.3 3.3 0.0059 16.3 3.3 3.7 3 2 0 3 3 3 1 Prokaryotic RING finger family 4 MMR_HSR1 PF01926.21 MSTRG.20761.2_2 - 1.7e-24 85.9 0.0 3.7e-24 84.9 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP1_OBG PF01018.20 MSTRG.20761.2_2 - 3.6e-18 65.5 5.8 1.8e-17 63.2 5.8 1.9 1 1 0 1 1 1 1 GTP1/OBG FeoB_N PF02421.16 MSTRG.20761.2_2 - 4.2e-10 39.2 0.1 4.3e-09 36.0 0.0 2.4 3 0 0 3 3 3 1 Ferrous iron transport protein B Arf PF00025.19 MSTRG.20761.2_2 - 9.2e-06 25.1 0.0 0.00044 19.6 0.0 2.4 2 0 0 2 2 2 1 ADP-ribosylation factor family ArgK PF03308.14 MSTRG.20761.2_2 - 0.00012 21.0 0.0 0.019 13.8 0.0 2.2 2 0 0 2 2 2 2 ArgK protein GTP_EFTU PF00009.25 MSTRG.20761.2_2 - 0.00013 21.4 0.0 0.0056 16.1 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.8 MSTRG.20761.2_2 - 0.0023 17.2 0.3 0.0078 15.5 0.0 2.0 2 1 1 3 3 3 1 Signal recognition particle receptor beta subunit MMR_HSR1_Xtn PF16897.3 MSTRG.20761.2_2 - 0.0049 16.8 0.0 0.015 15.2 0.0 1.7 1 1 0 1 1 1 1 C-terminal region of MMR_HSR1 domain cobW PF02492.17 MSTRG.20761.2_2 - 0.0083 15.6 0.0 0.67 9.4 0.0 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.15 MSTRG.20761.2_2 - 0.013 15.1 0.1 0.28 10.8 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein DUF2813 PF11398.6 MSTRG.20761.2_2 - 0.081 12.0 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) Dynamin_N PF00350.21 MSTRG.20761.2_2 - 0.13 12.2 0.3 11 5.9 0.1 2.5 1 1 1 2 2 2 0 Dynamin family TPR_2 PF07719.15 MSTRG.18785.1_3 - 5.9e-14 50.8 12.9 0.00085 19.1 0.0 5.4 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.18785.1_3 - 7.7e-12 44.4 7.3 0.02 14.6 0.1 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.18785.1_3 - 1.1e-11 44.4 9.7 0.063 14.0 0.0 5.9 2 2 3 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.18785.1_3 - 6.3e-11 41.4 5.1 0.0021 17.8 0.1 4.4 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.18785.1_3 - 4.5e-08 32.6 11.8 0.13 12.4 0.0 5.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.18785.1_3 - 1.1e-07 32.1 11.1 0.002 18.5 1.4 5.2 2 1 2 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.18785.1_3 - 7.5e-07 29.2 11.8 0.33 11.1 0.2 5.0 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.18785.1_3 - 9.4e-06 26.1 6.8 3.6 8.2 0.0 4.9 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_15 PF13429.4 MSTRG.18785.1_3 - 7e-05 22.0 2.9 0.016 14.3 0.9 2.9 1 1 2 3 3 3 1 Tetratricopeptide repeat SNAP PF14938.4 MSTRG.18785.1_3 - 0.0015 17.9 7.6 0.024 14.0 0.9 2.9 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP ANAPC3 PF12895.5 MSTRG.18785.1_3 - 0.0019 18.2 13.0 0.1 12.7 2.6 3.7 2 1 2 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.4 MSTRG.18785.1_3 - 0.0022 17.5 5.5 3.2 7.4 0.0 4.5 5 0 0 5 5 4 2 TPR repeat RPN7 PF10602.7 MSTRG.18785.1_3 - 0.0022 17.5 4.7 0.35 10.4 0.3 3.5 2 1 0 2 2 2 2 26S proteasome subunit RPN7 ChAPs PF09295.8 MSTRG.18785.1_3 - 0.0056 15.6 0.1 0.032 13.1 0.0 1.8 1 1 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) ANAPC8 PF04049.11 MSTRG.18785.1_3 - 0.0072 16.3 3.1 0.012 15.5 0.6 2.4 1 1 1 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_17 PF13431.4 MSTRG.18785.1_3 - 0.013 15.7 0.1 9.4 6.7 0.1 4.6 4 1 1 5 5 4 0 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.18785.1_3 - 0.017 14.9 9.0 3.8 7.4 0.1 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.18785.1_3 - 0.058 13.9 12.3 1.8 9.2 0.0 5.8 7 0 0 7 7 6 0 Tetratricopeptide repeat SRP_TPR_like PF17004.3 MSTRG.18785.1_3 - 1.7 8.5 6.5 0.69 9.8 1.0 2.6 1 1 1 2 2 2 0 Putative TPR-like repeat MIT PF04212.16 MSTRG.18785.1_3 - 2.8 7.9 10.3 4.6 7.3 0.2 4.0 2 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain LRRNT PF01462.16 MSTRG.10873.1_2 - 6 6.5 10.5 2.3 7.9 0.7 2.8 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain Pkinase PF00069.23 MSTRG.3116.3_1 - 5.2e-49 166.8 0.0 6.7e-49 166.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.3116.3_1 - 1.6e-24 86.5 0.0 2.5e-24 85.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.3116.3_1 - 2.5e-05 23.6 0.0 0.00011 21.5 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.12 MSTRG.3116.3_1 - 0.023 13.9 0.0 0.037 13.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EGF PF00008.25 MSTRG.17100.1_3 - 1.1e-46 156.5 165.0 2.7e-08 33.8 11.1 12.1 13 0 0 13 13 13 10 EGF-like domain hEGF PF12661.5 MSTRG.17100.1_3 - 6.4e-22 77.3 132.5 8e-06 26.2 10.0 12.8 12 0 0 12 12 12 9 Human growth factor-like EGF EGF_2 PF07974.11 MSTRG.17100.1_3 - 6.6e-11 42.2 158.9 0.00097 19.3 7.2 11.1 10 0 0 10 10 10 8 EGF-like domain EGF_CA PF07645.13 MSTRG.17100.1_3 - 0.00029 20.9 6.8 0.00029 20.9 6.8 11.3 5 3 5 10 10 10 4 Calcium-binding EGF domain EGF_3 PF12947.5 MSTRG.17100.1_3 - 0.00093 19.2 7.8 0.00093 19.2 7.8 11.1 11 0 0 11 11 11 8 EGF domain cEGF PF12662.5 MSTRG.17100.1_3 - 0.0032 17.3 2.0 0.0032 17.3 2.0 11.1 11 1 0 11 11 11 5 Complement Clr-like EGF-like Laminin_EGF PF00053.22 MSTRG.17100.1_3 - 1.6 8.8 132.5 0.44 10.6 5.5 11.2 4 1 7 11 11 11 0 Laminin EGF domain TIG PF01833.22 MSTRG.24648.1_2 - 5.9e-24 83.8 4.9 2.1e-09 37.2 1.5 3.8 4 0 0 4 4 4 3 IPT/TIG domain Radial_spoke PF04712.10 MSTRG.24648.1_2 - 0.24 10.2 2.4 0.33 9.7 2.4 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein I-set PF07679.14 MSTRG.23489.1_3 - 1.7e-48 162.5 0.0 2.8e-18 65.6 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.23489.1_3 - 2.5e-44 149.6 0.0 5.3e-15 55.7 0.2 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 MSTRG.23489.1_3 - 4.6e-26 90.7 0.0 6.1e-09 35.8 0.4 3.5 3 0 0 3 3 3 3 Immunoglobulin domain LRR_8 PF13855.4 MSTRG.23489.1_3 - 8.4e-25 86.2 16.0 4.4e-13 48.6 3.4 2.4 2 0 0 2 2 2 2 Leucine rich repeat Ig_2 PF13895.4 MSTRG.23489.1_3 - 2.5e-24 85.3 0.0 1.4e-06 28.4 0.2 3.7 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 MSTRG.23489.1_3 - 5.9e-15 55.2 1.2 2.1e-06 27.7 0.3 5.3 3 2 0 3 3 3 3 Immunoglobulin V-set domain LRR_4 PF12799.5 MSTRG.23489.1_3 - 4.9e-13 48.9 13.3 1.6e-05 25.0 2.3 3.6 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 MSTRG.23489.1_3 - 7e-11 42.1 0.8 2.3e-10 40.4 0.3 1.9 1 1 0 1 1 1 1 Leucine rich repeats (6 copies) C2-set_2 PF08205.10 MSTRG.23489.1_3 - 3.6e-10 39.7 0.0 0.0024 17.8 0.0 3.7 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain LRR_9 PF14580.4 MSTRG.23489.1_3 - 4.8e-06 26.0 1.9 0.0099 15.3 1.3 2.2 1 1 1 2 2 2 2 Leucine-rich repeat C1-set PF07654.13 MSTRG.23489.1_3 - 0.00027 21.2 0.0 0.13 12.6 0.1 3.5 3 0 0 3 3 3 1 Immunoglobulin C1-set domain Izumo-Ig PF16706.3 MSTRG.23489.1_3 - 0.0023 17.8 0.7 7.5 6.5 0.0 3.9 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain LRRCT PF01463.22 MSTRG.23489.1_3 - 0.019 15.3 0.3 0.31 11.5 0.1 3.1 3 0 0 3 3 3 0 Leucine rich repeat C-terminal domain V-set_CD47 PF08204.9 MSTRG.23489.1_3 - 0.019 14.8 0.1 17 5.3 0.0 3.1 3 0 0 3 3 3 0 CD47 immunoglobulin-like domain LRR_1 PF00560.31 MSTRG.23489.1_3 - 0.023 15.0 7.9 24 5.8 0.0 5.8 5 0 0 5 5 5 0 Leucine Rich Repeat SR-25 PF10500.7 MSTRG.4014.1_3 - 0.098 12.1 14.8 0.11 12.0 14.8 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ribosomal_S5 PF00333.18 MSTRG.18335.1_2 - 5.1e-20 71.1 0.3 8e-20 70.5 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.13 MSTRG.18335.1_2 - 8.2e-20 69.9 0.0 1.3e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain YbfN PF13982.4 MSTRG.18335.1_2 - 0.072 13.3 0.1 0.17 12.1 0.1 1.5 1 0 0 1 1 1 0 YbfN-like lipoprotein HrpF PF06266.10 MSTRG.26751.2_1 - 0.0051 17.0 0.9 0.019 15.2 0.9 2.0 1 0 0 1 1 1 1 HrpF protein Acid_PPase PF12689.5 MSTRG.26751.2_1 - 0.91 9.2 5.8 0.38 10.4 1.5 2.4 1 1 1 2 2 2 0 Acid Phosphatase EF-hand_4 PF12763.5 MSTRG.7317.1_2 - 1.6e-17 63.2 0.1 5e-17 61.6 0.0 1.8 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EHD_N PF16880.3 MSTRG.7317.1_2 - 4e-16 58.5 1.2 8.7e-16 57.4 1.2 1.6 1 0 0 1 1 1 1 N-terminal EH-domain containing protein Dynamin_N PF00350.21 MSTRG.7317.1_2 - 3.6e-14 53.0 0.0 8.9e-14 51.8 0.0 1.7 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.21 MSTRG.7317.1_2 - 1.4e-08 34.7 0.0 2.8e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase EF-hand_1 PF00036.30 MSTRG.7317.1_2 - 0.00056 19.1 0.0 0.0024 17.2 0.0 2.1 1 0 0 1 1 1 1 EF hand GTP_EFTU PF00009.25 MSTRG.7317.1_2 - 0.0044 16.4 0.1 0.031 13.7 0.1 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Roc PF08477.11 MSTRG.7317.1_2 - 0.0045 17.1 0.1 0.3 11.2 0.0 2.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.4 MSTRG.7317.1_2 - 0.0099 16.0 0.0 0.045 13.9 0.0 2.1 3 0 0 3 3 3 1 AAA domain FeoB_N PF02421.16 MSTRG.7317.1_2 - 0.023 14.1 0.0 1.4 8.3 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_16 PF13191.4 MSTRG.7317.1_2 - 0.038 14.2 0.1 0.19 12.0 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain Histone PF00125.22 MSTRG.28592.1_1 - 1.5e-16 60.9 0.0 1.7e-16 60.7 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.3 MSTRG.28592.1_1 - 3.6e-14 52.1 0.4 5.6e-14 51.4 0.4 1.3 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.21 MSTRG.28592.1_1 - 3.7e-05 23.8 0.0 5e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF501 PF04417.10 MSTRG.3553.9_2 - 0.075 12.7 3.3 0.23 11.1 3.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF501) Adaptin_N PF01602.18 MSTRG.9827.1_1 - 3.7e-117 391.9 8.4 4.6e-117 391.6 8.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region AP3B1_C PF14796.4 MSTRG.9827.1_1 - 3.1e-50 170.1 0.1 6.3e-50 169.1 0.1 1.5 1 0 0 1 1 1 1 Clathrin-adaptor complex-3 beta-1 subunit C-terminal Cnd1 PF12717.5 MSTRG.9827.1_1 - 1.4e-08 34.8 6.6 0.0014 18.5 0.2 3.6 2 1 0 3 3 3 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.20 MSTRG.9827.1_1 - 0.096 12.8 0.1 1.7e+02 2.8 0.0 4.7 4 0 0 4 4 4 0 HEAT repeat HemolysinCabind PF00353.17 MSTRG.9827.1_1 - 1.5 9.4 4.8 3.2 8.5 4.8 1.5 1 0 0 1 1 1 0 Haemolysin-type calcium-binding repeat (2 copies) SNF2_N PF00176.21 MSTRG.1464.1_2 - 5.8e-75 252.0 3.3 2.5e-74 250.0 0.2 2.1 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.29 MSTRG.1464.1_2 - 3.4e-11 43.3 0.0 1.1e-10 41.7 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-GRF PF06839.10 MSTRG.1464.1_2 - 1.3e-07 31.5 6.6 4.4e-07 29.7 1.3 2.6 2 0 0 2 2 2 1 GRF zinc finger ResIII PF04851.13 MSTRG.1464.1_2 - 1.9e-06 27.9 0.0 3.7e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SlyX PF04102.10 MSTRG.1464.1_2 - 0.21 12.1 0.8 12 6.4 0.1 3.0 2 0 0 2 2 2 0 SlyX DHR-2 PF06920.11 MSTRG.25293.3_2 - 2.7e-207 689.5 4.6 4.3e-207 688.8 4.6 1.3 1 0 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.4 MSTRG.25293.3_2 - 6.5e-44 149.9 0.2 1.5e-43 148.7 0.2 1.6 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins Ion_trans PF00520.29 MSTRG.18719.1_3 - 2e-15 56.6 0.6 2e-15 56.6 0.6 1.6 2 0 0 2 2 2 1 Ion transport protein RGS-like PF09128.9 MSTRG.13649.1_1 - 0.22 11.1 3.8 0.35 10.4 3.8 1.2 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain DEAD PF00270.27 MSTRG.13649.1_2 - 3.5e-45 153.8 0.2 1.8e-44 151.4 0.1 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.13649.1_2 - 4.2e-31 107.5 0.5 1e-29 103.0 0.3 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.13649.1_2 - 4.6e-07 29.9 0.5 3.1e-06 27.2 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.4 MSTRG.13649.1_2 - 0.006 16.7 1.7 0.01 15.9 0.2 2.2 2 1 0 2 2 2 1 AAA domain UTP25 PF06862.10 MSTRG.13649.1_2 - 0.023 13.4 2.7 0.039 12.6 0.1 2.4 2 1 1 3 3 3 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 PRK PF00485.16 MSTRG.13649.1_2 - 1.5 8.4 5.8 0.56 9.8 0.0 2.8 3 1 1 4 4 4 0 Phosphoribulokinase / Uridine kinase family RRN3 PF05327.9 MSTRG.2164.1_1 - 1.4e-130 436.4 0.0 2.2e-130 435.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 zf-HIT PF04438.14 MSTRG.22249.1_3 - 2.8e-10 39.7 8.2 5.4e-10 38.8 8.2 1.5 1 0 0 1 1 1 1 HIT zinc finger PolC_DP2 PF03833.11 MSTRG.22249.1_3 - 0.59 7.8 2.7 0.65 7.7 2.7 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 FXa_inhibition PF14670.4 MSTRG.20328.1_2 - 4.9e-55 183.4 192.7 2e-11 43.8 8.4 13.8 14 0 0 14 14 14 9 Coagulation Factor Xa inhibitory site cEGF PF12662.5 MSTRG.20328.1_2 - 4.5e-49 163.8 81.3 1e-08 34.8 1.0 12.7 11 0 0 11 11 11 9 Complement Clr-like EGF-like Ephrin_rec_like PF07699.11 MSTRG.20328.1_2 - 4.4e-36 122.3 44.0 1.1e-14 53.8 7.3 5.8 5 0 0 5 5 5 3 Putative ephrin-receptor like EGF_CA PF07645.13 MSTRG.20328.1_2 - 2.2e-33 114.0 160.7 1.3e-08 34.7 7.8 11.7 12 0 0 12 12 12 7 Calcium-binding EGF domain CUB PF00431.18 MSTRG.20328.1_2 - 5.1e-17 62.1 0.0 1.1e-16 61.1 0.0 1.6 1 0 0 1 1 1 1 CUB domain EGF_3 PF12947.5 MSTRG.20328.1_2 - 2.2e-15 56.4 146.1 2.2e-09 37.2 8.5 12.1 12 0 0 12 12 12 7 EGF domain EGF PF00008.25 MSTRG.20328.1_2 - 3.1e-10 40.0 146.5 2e-05 24.7 2.6 12.9 13 1 1 14 14 14 8 EGF-like domain hEGF PF12661.5 MSTRG.20328.1_2 - 0.0043 17.6 0.5 0.0043 17.6 0.5 14.6 14 1 0 14 14 14 6 Human growth factor-like EGF V-ATPase_G PF03179.13 MSTRG.20328.1_2 - 0.037 14.4 0.6 0.07 13.5 0.6 1.3 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit RRM_1 PF00076.20 MSTRG.17510.2_3 - 2.8e-30 103.8 0.0 3.7e-14 52.2 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Es2 PF09751.7 MSTRG.17510.2_3 - 0.078 12.6 0.1 0.12 11.9 0.1 1.2 1 0 0 1 1 1 0 Nuclear protein Es2 HEAT_2 PF13646.4 MSTRG.25577.1_2 - 0.019 15.2 0.3 2.1 8.7 0.0 3.2 2 0 0 2 2 2 0 HEAT repeats DED PF01335.19 MSTRG.25577.1_2 - 0.19 11.9 1.3 0.52 10.5 0.3 2.3 2 0 0 2 2 2 0 Death effector domain DUF3453 PF11935.6 MSTRG.25577.1_2 - 0.54 9.7 6.4 1.6 8.2 0.1 3.2 3 1 1 4 4 4 0 Domain of unknown function (DUF3453) TBP PF00352.19 MSTRG.23202.1_3 - 1.5e-64 213.8 0.2 1.5e-31 108.0 0.1 2.2 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) SUIM_assoc PF16619.3 MSTRG.23202.1_3 - 0.015 15.3 4.1 0.028 14.4 4.1 1.6 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DUF3378 PF11858.6 MSTRG.23202.1_3 - 0.039 13.9 2.4 6.1 6.9 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3378) TFIIA PF03153.11 MSTRG.23202.1_3 - 0.56 10.0 8.4 0.75 9.6 8.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.6 MSTRG.23202.1_3 - 0.7 9.3 10.7 1 8.8 10.7 1.1 1 0 0 1 1 1 0 Spt20 family ODC_AZ PF02100.15 MSTRG.6236.1_3 - 4.4e-19 68.5 0.0 6.8e-19 67.8 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Rad51 PF08423.9 MSTRG.17927.3_3 - 2e-09 37.0 0.0 2.8e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.4 MSTRG.17927.3_3 - 4e-05 23.2 0.0 6.8e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain NACHT PF05729.10 MSTRG.17927.3_3 - 0.00016 21.5 0.1 0.018 14.8 0.0 2.1 2 0 0 2 2 2 2 NACHT domain RecA PF00154.19 MSTRG.17927.3_3 - 0.0088 15.4 0.0 0.047 13.0 0.0 1.8 1 1 1 2 2 2 1 recA bacterial DNA recombination protein AAA_24 PF13479.4 MSTRG.17927.3_3 - 0.0098 15.5 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 MSTRG.17927.3_3 - 0.016 15.5 0.3 0.033 14.4 0.2 1.6 1 1 1 2 2 2 0 AAA ATPase domain TCO89 PF10452.7 MSTRG.27997.1_2 - 0.25 10.1 0.1 0.24 10.2 0.1 1.0 1 0 0 1 1 1 0 TORC1 subunit TCO89 I-set PF07679.14 MSTRG.19444.1_1 - 7e-25 86.8 0.0 3.6e-16 58.9 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.19444.1_1 - 1.9e-19 69.9 0.8 3.6e-11 43.4 0.0 2.9 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.19444.1_1 - 1.4e-14 54.1 0.0 9.6e-08 32.1 0.0 2.9 3 0 0 3 3 3 2 Immunoglobulin domain fn3 PF00041.19 MSTRG.19444.1_1 - 1.4e-13 50.8 0.0 2.6e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain ig PF00047.23 MSTRG.19444.1_1 - 3.1e-09 36.8 0.0 4.2e-06 26.7 0.0 2.8 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 MSTRG.19444.1_1 - 4.6e-05 23.4 0.0 0.26 11.3 0.0 3.2 2 1 1 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 MSTRG.19444.1_1 - 0.00044 20.1 0.0 0.82 9.6 0.0 2.5 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain AMP-binding PF00501.26 MSTRG.11170.2_1 - 5.8e-81 272.1 0.0 7e-81 271.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme adh_short PF00106.23 MSTRG.6441.1_3 - 2.3e-51 173.9 0.2 3.1e-51 173.5 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 MSTRG.6441.1_3 - 1.1e-37 129.7 0.2 1.4e-37 129.3 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 MSTRG.6441.1_3 - 6.4e-13 48.9 0.1 9.6e-13 48.3 0.1 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.13 MSTRG.6441.1_3 - 0.0028 16.7 0.0 0.0043 16.1 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF1776 PF08643.8 MSTRG.6441.1_3 - 0.0037 16.5 0.0 0.0059 15.9 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) DSPc PF00782.18 MSTRG.8929.1_2 - 2.7e-13 49.7 0.0 6.3e-13 48.5 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 MSTRG.8929.1_2 - 3.8e-07 30.2 0.0 7.2e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.25 MSTRG.8929.1_2 - 7.9e-07 28.7 0.0 1.6e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.11 MSTRG.8929.1_2 - 0.0062 16.0 0.0 0.012 15.0 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.4 MSTRG.8929.1_2 - 0.064 13.1 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family HAP1_N PF04849.11 MSTRG.25316.5_3 - 1.5e-99 333.0 25.3 1.8e-99 332.8 25.3 1.0 1 0 0 1 1 1 1 HAP1 N-terminal conserved region BLOC1_2 PF10046.7 MSTRG.25316.5_3 - 0.013 15.7 7.0 0.013 15.7 7.0 3.5 2 2 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2254 PF10011.7 MSTRG.25316.5_3 - 0.046 12.4 1.5 2.7 6.6 0.1 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2254) DUF972 PF06156.11 MSTRG.25316.5_3 - 0.28 11.7 31.6 0.48 10.9 3.0 3.5 2 2 1 3 3 3 0 Protein of unknown function (DUF972) Flu_NS2 PF00601.17 MSTRG.25316.5_3 - 0.63 10.2 7.9 0.53 10.5 0.2 2.6 2 1 0 2 2 2 0 Influenza non-structural protein (NS2) Cnn_1N PF07989.9 MSTRG.25316.5_3 - 0.73 9.9 29.3 0.15 12.1 2.5 3.8 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 ZapB PF06005.10 MSTRG.25316.5_3 - 1.1 9.6 44.2 0.94 9.8 5.6 4.2 2 1 2 4 4 4 0 Cell division protein ZapB tRNA_lig_kinase PF08303.9 MSTRG.25316.5_3 - 1.3 8.9 5.2 1.7 8.6 1.5 2.1 2 0 0 2 2 2 0 tRNA ligase kinase domain ATG16 PF08614.9 MSTRG.25316.5_3 - 1.4 8.9 35.2 0.12 12.4 13.0 2.8 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF4618 PF15397.4 MSTRG.25316.5_3 - 1.4 8.2 27.9 1 8.6 17.2 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4618) DUF4279 PF14106.4 MSTRG.25316.5_3 - 1.8 8.6 5.1 5.9 7.0 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4279) bZIP_1 PF00170.19 MSTRG.25316.5_3 - 3.7 7.6 29.4 3.1 7.8 2.3 4.4 2 1 2 4 4 4 0 bZIP transcription factor DUF4201 PF13870.4 MSTRG.25316.5_3 - 3.7 7.0 31.9 1.2 8.6 1.2 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) DUF2968 PF11180.6 MSTRG.25316.5_3 - 5.2 6.6 23.9 2.4 7.7 3.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) GFA PF04828.12 MSTRG.29109.1_2 - 0.0088 16.2 0.2 0.8 10.0 0.0 2.1 1 1 1 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme zf-UBR PF02207.18 MSTRG.29109.1_2 - 0.065 13.3 1.1 0.13 12.3 1.1 1.5 1 1 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) Patched PF02460.16 MSTRG.12873.1_2 - 5.2e-81 272.8 23.8 1.6e-52 178.6 0.7 2.0 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.6 MSTRG.12873.1_2 - 3.4e-56 189.2 5.5 3.4e-56 189.2 5.5 2.4 2 0 0 2 2 2 2 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.13 MSTRG.12873.1_2 - 1.8e-05 23.7 2.7 1.8e-05 23.7 2.7 2.0 2 1 0 2 2 2 1 MMPL family ACR_tran PF00873.17 MSTRG.12873.1_2 - 0.00074 17.2 16.4 0.09 10.3 0.2 2.2 2 0 0 2 2 2 2 AcrB/AcrD/AcrF family SH3BGR PF04908.13 MSTRG.16459.1_1 - 3.6e-39 132.8 0.0 4.7e-39 132.4 0.0 1.2 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.22 MSTRG.16459.1_1 - 0.015 15.4 0.0 0.024 14.7 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin SLAIN PF15301.4 MSTRG.23883.3_1 - 1.8e-115 386.5 46.5 7.8e-76 255.9 13.7 3.3 1 1 1 2 2 2 2 SLAIN motif-containing family Autophagy_act_C PF03987.13 MSTRG.15696.1_2 - 1.5e-16 60.5 0.6 2.8e-16 59.7 0.6 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Sec23_trunk PF04811.13 MSTRG.931.4_3 - 1.8e-84 283.0 0.2 2.4e-84 282.6 0.2 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain zf-Sec23_Sec24 PF04810.13 MSTRG.931.4_3 - 8.5e-15 54.4 4.5 1.7e-14 53.4 4.5 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.10 MSTRG.931.4_3 - 9e-13 48.7 0.0 2.3e-12 47.3 0.0 1.8 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sen15 PF09631.8 MSTRG.931.4_3 - 0.13 12.4 0.0 0.3 11.3 0.0 1.5 1 0 0 1 1 1 0 Sen15 protein RVT_1 PF00078.25 MSTRG.15006.1_2 - 9.9e-08 31.6 0.0 1.4e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Homeobox PF00046.27 MSTRG.6721.2_1 - 0.0001 21.9 0.0 0.00021 20.9 0.0 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 MSTRG.6721.2_1 - 0.02 14.7 0.1 0.04 13.7 0.1 1.5 1 0 0 1 1 1 0 Homeobox KN domain zf-C2HE PF16278.3 MSTRG.6721.2_1 - 0.22 11.9 5.6 1.8 8.9 2.0 2.4 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Nebulin PF00880.16 MSTRG.1479.4_1 - 0 1655.5 550.3 2.4e-10 40.0 2.0 134.7 140 0 0 140 140 140 107 Nebulin repeat SH3_1 PF00018.26 MSTRG.1479.4_1 - 3e-12 45.8 0.0 1.4e-11 43.6 0.0 2.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.1479.4_1 - 3.3e-12 45.9 0.0 7.1e-12 44.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Peptidase_M24 PF00557.22 MSTRG.1479.4_1 - 6.3e-12 45.5 3.4 0.27 10.8 0.0 8.5 8 0 0 8 8 8 4 Metallopeptidase family M24 SH3_2 PF07653.15 MSTRG.1479.4_1 - 9.5e-06 25.1 0.0 7.6e-05 22.2 0.0 2.6 2 0 0 2 2 2 1 Variant SH3 domain Toprim_2 PF13155.4 MSTRG.1479.4_1 - 0.36 11.2 7.7 66 4.0 0.0 6.2 6 0 0 6 6 6 0 Toprim-like EGF PF00008.25 MSTRG.23906.1_1 - 2e-08 34.3 19.9 2.3e-05 24.5 8.6 2.6 2 0 0 2 2 2 2 EGF-like domain EGF_2 PF07974.11 MSTRG.23906.1_1 - 2.3e-06 27.7 24.7 0.0012 19.0 9.7 3.1 3 0 0 3 3 3 2 EGF-like domain hEGF PF12661.5 MSTRG.23906.1_1 - 4.2e-05 23.9 19.0 0.0082 16.7 6.3 3.3 3 0 0 3 3 3 2 Human growth factor-like EGF EGF_CA PF07645.13 MSTRG.23906.1_1 - 0.00026 21.0 21.2 0.12 12.4 4.6 3.1 2 1 1 3 3 3 2 Calcium-binding EGF domain Laminin_EGF PF00053.22 MSTRG.23906.1_1 - 0.022 14.7 19.8 0.87 9.6 7.7 3.0 2 1 1 3 3 3 0 Laminin EGF domain FXa_inhibition PF14670.4 MSTRG.23906.1_1 - 1.4 9.2 16.9 1.8 8.8 1.5 2.9 2 1 1 3 3 3 0 Coagulation Factor Xa inhibitory site EGF_alliinase PF04863.11 MSTRG.23906.1_1 - 3 8.2 15.0 4.7 7.5 6.9 2.5 1 1 1 2 2 2 0 Alliinase EGF-like domain EGF_3 PF12947.5 MSTRG.23906.1_1 - 5 7.3 19.9 4.2 7.5 3.1 2.8 2 0 0 2 2 2 0 EGF domain zf-H2C2_2 PF13465.4 MSTRG.13705.2_2 - 3.5e-37 125.1 49.3 4.6e-09 36.2 0.5 7.7 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.13705.2_2 - 4.5e-33 111.7 49.7 7.8e-06 25.9 0.3 7.8 7 0 0 7 7 7 7 Zinc finger, C2H2 type BTB PF00651.29 MSTRG.13705.2_2 - 1.9e-26 92.4 3.1 3.4e-26 91.5 0.4 2.3 2 0 0 2 2 2 1 BTB/POZ domain zf-C2H2_4 PF13894.4 MSTRG.13705.2_2 - 1.5e-19 68.9 48.6 0.00078 19.9 0.3 8.1 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.13705.2_2 - 3.6e-14 52.2 44.0 0.00094 18.9 0.2 7.8 7 0 0 7 7 7 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.13705.2_2 - 5.4e-13 48.7 27.9 0.12 12.6 1.8 7.8 7 0 0 7 7 7 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.13705.2_2 - 7.3e-13 48.3 36.9 0.0024 18.1 1.7 8.0 7 0 0 7 7 7 6 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.8 MSTRG.13705.2_2 - 0.00039 20.4 25.8 0.081 12.9 1.5 5.1 3 1 0 4 4 4 2 Zinc ribbon domain GAGA PF09237.9 MSTRG.13705.2_2 - 0.017 14.8 7.6 0.37 10.5 0.1 4.4 3 2 1 5 5 5 0 GAGA factor Ta0938 PF11494.6 MSTRG.13705.2_2 - 0.095 12.9 7.8 0.17 12.0 0.2 3.5 1 1 2 3 3 3 0 Ta0938 DUF3268 PF11672.6 MSTRG.13705.2_2 - 1.9 8.7 17.4 4.2 7.6 0.4 4.1 4 1 1 5 5 4 0 zinc-finger-containing domain zf-C2H2_11 PF16622.3 MSTRG.13705.2_2 - 10 5.9 40.7 0.66 9.6 1.0 6.5 7 0 0 7 7 6 0 zinc-finger C2H2-type Peptidase_A22B PF04258.11 MSTRG.18090.2_3 - 3.9e-99 331.6 9.1 3.9e-99 331.6 9.1 2.0 3 0 0 3 3 3 1 Signal peptide peptidase SPP PF06550.9 MSTRG.18090.2_3 - 0.00024 20.5 7.1 0.0004 19.8 7.1 1.4 1 0 0 1 1 1 1 Signal-peptide peptidase, presenilin aspartyl protease DUF4345 PF14248.4 MSTRG.18090.2_3 - 0.0011 18.7 0.4 0.0011 18.7 0.4 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4345) Presenilin PF01080.15 MSTRG.18090.2_3 - 0.063 11.9 7.2 0.011 14.4 3.2 1.7 1 1 1 2 2 2 0 Presenilin COesterase PF00135.26 MSTRG.20649.1_2 - 1.1e-56 192.7 0.0 1.4e-56 192.3 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family COesterase PF00135.26 MSTRG.20649.1_3 - 4.6e-40 137.9 0.1 6e-40 137.5 0.1 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 MSTRG.20649.1_3 - 0.072 12.8 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold DPPIV_N PF00930.19 MSTRG.20223.1_1 - 6.7e-94 314.4 5.4 9.5e-94 313.9 5.4 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.19 MSTRG.20223.1_1 - 1.8e-51 174.5 4.3 2.9e-51 173.8 4.3 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.16 MSTRG.20223.1_1 - 0.00011 21.7 0.1 0.0003 20.3 0.1 1.6 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.5 MSTRG.20223.1_1 - 0.0019 18.8 0.0 0.014 15.9 0.0 2.1 1 1 1 2 2 2 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.16 MSTRG.20223.1_1 - 0.0085 15.6 4.3 0.13 11.7 3.4 2.3 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) LIP PF03583.12 MSTRG.20223.1_1 - 0.011 14.9 0.2 0.026 13.7 0.2 1.5 1 0 0 1 1 1 0 Secretory lipase Abhydrolase_2 PF02230.14 MSTRG.20223.1_1 - 0.013 15.2 0.6 0.61 9.7 0.3 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase FSH1 PF03959.11 MSTRG.20223.1_1 - 0.1 12.1 0.0 0.26 10.8 0.0 1.6 1 0 0 1 1 1 0 Serine hydrolase (FSH1) PD40 PF07676.10 MSTRG.20223.1_1 - 0.44 10.4 3.5 31 4.5 0.1 3.8 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat EGF_CA PF07645.13 MSTRG.650.2_2 - 1e-58 195.2 140.8 2.3e-10 40.4 6.3 11.5 11 0 0 11 11 11 9 Calcium-binding EGF domain cEGF PF12662.5 MSTRG.650.2_2 - 2.8e-54 180.5 58.2 9.3e-08 31.7 1.4 10.4 9 0 0 9 9 9 9 Complement Clr-like EGF-like TB PF00683.15 MSTRG.650.2_2 - 4.1e-17 61.4 18.4 3.6e-13 48.9 3.9 4.3 4 0 0 4 4 4 2 TB domain EGF PF00008.25 MSTRG.650.2_2 - 3.3e-10 39.9 129.6 0.00023 21.3 8.1 11.7 11 1 1 12 12 12 6 EGF-like domain FXa_inhibition PF14670.4 MSTRG.650.2_2 - 5.5e-10 39.2 138.0 0.0037 17.4 6.7 10.9 7 1 4 11 11 11 7 Coagulation Factor Xa inhibitory site hEGF PF12661.5 MSTRG.650.2_2 - 6.5e-06 26.5 30.9 0.00021 21.7 5.4 13.0 12 0 0 12 12 12 4 Human growth factor-like EGF EGF_MSP1_1 PF12946.5 MSTRG.650.2_2 - 0.0057 16.5 99.0 0.007 16.3 5.0 9.9 9 0 0 9 9 9 6 MSP1 EGF domain 1 EGF_3 PF12947.5 MSTRG.650.2_2 - 0.02 14.9 0.7 0.02 14.9 0.7 10.7 7 1 2 9 9 9 0 EGF domain Macoilin PF09726.7 MSTRG.650.2_2 - 1.1 7.7 7.5 1.4 7.2 7.5 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF1388 PF07142.10 MSTRG.650.2_3 - 0.01 15.7 15.3 1.5 8.7 2.0 5.0 3 1 0 3 3 3 3 Repeat of unknown function (DUF1388) Nudc_N PF14050.4 MSTRG.24673.3_2 - 3.4e-25 87.7 0.1 5.4e-25 87.0 0.1 1.3 1 0 0 1 1 1 1 N-terminal conserved domain of Nudc. CS PF04969.14 MSTRG.24673.3_2 - 7.8e-15 55.5 0.2 1.3e-14 54.8 0.2 1.4 1 0 0 1 1 1 1 CS domain DUF1737 PF08410.8 MSTRG.24673.3_2 - 0.0066 16.1 0.1 0.082 12.6 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF1737) Syntaxin_2 PF14523.4 MSTRG.18848.1_2 - 6.8e-31 106.5 16.7 5.5e-30 103.6 11.5 2.2 2 0 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.17 MSTRG.18848.1_2 - 1.5e-20 72.8 0.3 3.4e-20 71.6 0.3 1.7 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.23 MSTRG.18848.1_2 - 5.6e-14 52.1 15.0 9.6e-14 51.4 15.0 1.3 1 0 0 1 1 1 1 Syntaxin Spore_III_AB PF09548.8 MSTRG.18848.1_2 - 0.084 12.9 0.2 0.084 12.9 0.2 2.8 2 1 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) MitMem_reg PF13012.4 MSTRG.18848.1_2 - 0.51 10.7 3.7 0.19 12.1 0.9 1.7 2 0 0 2 2 2 0 Maintenance of mitochondrial structure and function DUF1664 PF07889.10 MSTRG.18848.1_2 - 0.61 10.0 8.4 1.6 8.6 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF1359 PF07097.9 MSTRG.18848.1_2 - 0.66 10.1 5.1 2.9 8.1 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1359) Synaptobrevin PF00957.19 MSTRG.18848.1_2 - 1 9.1 12.7 0.41 10.3 2.9 3.0 2 1 1 3 3 3 0 Synaptobrevin TMCO5 PF14992.4 MSTRG.18848.1_2 - 5.8 6.3 15.7 1.4 8.3 1.4 2.1 2 0 0 2 2 2 0 TMCO5 family DUF16 PF01519.14 MSTRG.18848.1_2 - 7.8 6.9 9.7 7.6 6.9 3.0 2.5 2 0 0 2 2 2 0 Protein of unknown function DUF16 OmpH PF03938.12 MSTRG.18848.1_2 - 9.7 6.0 24.1 0.51 10.2 12.8 2.3 1 1 0 2 2 2 0 Outer membrane protein (OmpH-like) NCKAP5 PF15246.4 MSTRG.734.1_3 - 6.1e-48 163.9 12.0 1e-34 120.5 8.0 2.2 2 0 0 2 2 2 2 Nck-associated protein 5, Peripheral clock protein MGTL PF17059.3 MSTRG.734.1_3 - 4.7 7.0 6.9 0.69 9.7 0.2 2.9 2 0 0 2 2 2 0 MgtA leader peptide MTP18 PF10558.7 MSTRG.11988.1_3 - 4.4e-19 68.9 0.3 9.3e-19 67.9 0.3 1.5 1 1 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) Zona_pellucida PF00100.21 MSTRG.8389.1_1 - 7.2e-42 143.8 0.0 1.2e-41 143.0 0.0 1.4 1 1 0 1 1 1 1 Zona pellucida-like domain zf-DHHC PF01529.18 MSTRG.15835.1_1 - 3.3e-29 101.6 13.7 3.3e-29 101.6 13.7 2.7 3 0 0 3 3 3 1 DHHC palmitoyltransferase Ig_4 PF16680.3 MSTRG.21240.1_1 - 3.8e-09 36.6 0.8 3.8e-09 36.6 0.8 1.9 2 0 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.3 MSTRG.21240.1_1 - 1.1e-07 32.0 0.4 2.3e-07 31.0 0.4 1.5 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain DAP10 PF07213.9 MSTRG.21240.1_1 - 0.017 14.9 0.1 0.049 13.5 0.1 1.7 1 0 0 1 1 1 0 DAP10 membrane protein DnaJ_C PF01556.16 MSTRG.2424.1_1 - 3.8e-42 143.7 0.2 5.1e-42 143.3 0.2 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.29 MSTRG.2424.1_1 - 6e-24 83.8 1.1 9.8e-24 83.1 1.1 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.17 MSTRG.2424.1_1 - 5.5e-15 55.4 16.9 1.1e-14 54.4 16.9 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.3 MSTRG.2424.1_1 - 0.15 11.9 10.0 0.27 11.1 1.3 2.6 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein A2L_zn_ribbon PF08792.8 MSTRG.2424.1_1 - 2.8 7.6 11.1 0.53 9.9 3.4 2.9 2 0 0 2 2 2 0 A2L zinc ribbon domain zf-H2C2_2 PF13465.4 MSTRG.4994.1_2 - 1.8e-42 141.8 39.8 5.6e-09 35.9 0.8 7.4 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.4994.1_2 - 3.5e-32 108.9 44.4 4.1e-06 26.8 2.8 6.4 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.4994.1_2 - 2.1e-26 90.2 39.2 0.00016 22.1 0.7 6.4 6 0 0 6 6 6 6 C2H2-type zinc finger zf-met PF12874.5 MSTRG.4994.1_2 - 6.7e-10 38.9 34.6 0.023 15.0 1.0 6.4 6 0 0 6 6 6 4 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 MSTRG.4994.1_2 - 8.5e-10 38.2 43.3 0.00065 19.4 0.4 6.9 6 2 0 6 6 6 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.4994.1_2 - 1.1e-08 35.0 17.8 0.014 15.6 0.3 6.2 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 MSTRG.4994.1_2 - 1.9e-06 28.0 29.3 0.1 12.8 6.3 6.3 3 1 3 6 6 5 4 C2H2 type zinc-finger (2 copies) LIM PF00412.20 MSTRG.4994.1_2 - 1.3e-05 25.2 16.9 0.11 12.6 3.3 5.2 4 2 0 4 4 4 2 LIM domain zf-BED PF02892.13 MSTRG.4994.1_2 - 1.9e-05 24.5 34.4 0.16 11.9 3.3 6.3 2 1 4 6 6 6 3 BED zinc finger zf-H2C2_5 PF13909.4 MSTRG.4994.1_2 - 3.3e-05 23.4 32.7 0.31 10.7 1.3 6.8 6 1 0 6 6 6 5 C2H2-type zinc-finger domain zf-FCS PF06467.12 MSTRG.4994.1_2 - 5.2e-05 23.0 24.6 0.4 10.6 0.4 5.7 1 1 5 6 6 6 3 MYM-type Zinc finger with FCS sequence motif zf-Di19 PF05605.10 MSTRG.4994.1_2 - 0.00015 21.9 26.0 0.0052 16.9 1.1 4.7 2 1 4 6 6 5 3 Drought induced 19 protein (Di19), zinc-binding Elf1 PF05129.11 MSTRG.4994.1_2 - 0.0059 16.5 21.2 0.2 11.6 1.4 3.6 1 1 2 3 3 3 2 Transcription elongation factor Elf1 like HypA PF01155.17 MSTRG.4994.1_2 - 0.014 15.3 13.6 0.26 11.2 0.3 3.4 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.3 MSTRG.4994.1_2 - 0.014 16.0 16.2 0.2 12.3 1.6 3.6 1 1 3 5 5 5 0 zinc-ribbon family MBD PF01429.17 MSTRG.4994.1_2 - 0.015 14.9 0.1 3.8 7.2 0.0 3.8 1 1 1 2 2 2 0 Methyl-CpG binding domain Zn-ribbon_8 PF09723.8 MSTRG.4994.1_2 - 0.029 14.3 18.0 0.33 11.0 3.5 4.5 2 1 3 5 5 5 0 Zinc ribbon domain zf-LYAR PF08790.9 MSTRG.4994.1_2 - 0.051 13.4 25.3 1.5 8.6 0.2 5.9 6 0 0 6 6 6 0 LYAR-type C2HC zinc finger C1_1 PF00130.20 MSTRG.4994.1_2 - 0.074 12.8 19.6 0.58 9.9 1.5 4.4 1 1 4 5 5 5 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Chordopox_RPO7 PF05864.10 MSTRG.4994.1_2 - 0.09 12.9 6.3 31 4.8 0.0 4.9 5 0 0 5 5 5 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) C1_2 PF03107.14 MSTRG.4994.1_2 - 0.11 12.7 25.0 3.9 7.7 0.1 5.9 2 2 2 4 4 4 0 C1 domain zf-AN1 PF01428.14 MSTRG.4994.1_2 - 0.27 11.3 29.0 4.8 7.3 0.3 6.3 5 1 1 6 6 6 0 AN1-like Zinc finger ADK_lid PF05191.12 MSTRG.4994.1_2 - 0.69 9.9 11.4 8.1 6.4 0.2 4.5 3 1 2 5 5 5 0 Adenylate kinase, active site lid zf-C2HE PF16278.3 MSTRG.4994.1_2 - 2.8 8.3 29.7 29 5.1 1.6 6.4 2 1 3 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger PyrI_C PF02748.13 MSTRG.4994.1_2 - 2.9 7.8 12.6 10 6.0 0.2 4.6 2 2 3 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C4_ClpX PF06689.11 MSTRG.4994.1_2 - 2.9 7.7 29.0 0.38 10.6 0.1 6.6 7 0 0 7 7 7 0 ClpX C4-type zinc finger zf-TRAF PF02176.16 MSTRG.4994.1_2 - 5.2 7.7 20.2 0.62 10.7 3.0 3.8 1 1 3 4 4 4 0 TRAF-type zinc finger DUF3268 PF11672.6 MSTRG.4994.1_2 - 5.6 7.2 9.9 1.7 8.9 0.5 3.1 1 1 4 5 5 5 0 zinc-finger-containing domain zf-C2HC_2 PF13913.4 MSTRG.4994.1_2 - 9.5 6.1 20.0 24 4.9 0.1 5.4 5 0 0 5 5 5 0 zinc-finger of a C2HC-type Guanylate_cyc PF00211.18 MSTRG.25774.1_2 - 6.2e-65 218.1 0.1 8.1e-65 217.7 0.1 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Lectin_C PF00059.19 MSTRG.20188.2_3 - 3.6e-20 72.6 0.0 5.8e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.10 MSTRG.20188.2_3 - 0.00076 19.0 0.1 0.0014 18.2 0.1 1.4 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Adenylsucc_synt PF00709.19 MSTRG.7577.6_1 - 2.7e-181 602.9 0.1 3.1e-181 602.7 0.1 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase Pkinase PF00069.23 MSTRG.24784.1_2 - 7.9e-56 189.2 0.0 1.1e-55 188.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.24784.1_2 - 2.4e-34 118.7 0.0 3.9e-34 118.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase I-set PF07679.14 MSTRG.24784.1_2 - 4.2e-17 61.9 0.0 7.3e-17 61.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.24784.1_2 - 4.1e-14 52.8 0.0 1.2e-13 51.4 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.24784.1_2 - 5.1e-08 33.0 0.0 1.4e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 MSTRG.24784.1_2 - 3.6e-07 30.1 0.0 1.3e-06 28.3 0.0 2.0 1 0 0 1 1 1 1 Immunoglobulin domain fn3 PF00041.19 MSTRG.24784.1_2 - 6.1e-07 29.6 0.1 1.6e-06 28.2 0.1 1.8 1 0 0 1 1 1 1 Fibronectin type III domain Kinase-like PF14531.4 MSTRG.24784.1_2 - 0.00019 20.7 0.0 0.00065 19.0 0.0 1.8 1 1 0 1 1 1 1 Kinase-like V-set PF07686.15 MSTRG.24784.1_2 - 0.002 18.1 0.0 2.5 8.2 0.0 2.7 1 1 1 2 2 2 2 Immunoglobulin V-set domain RIO1 PF01163.20 MSTRG.24784.1_2 - 0.0031 17.0 0.5 0.0055 16.2 0.5 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.21 MSTRG.24784.1_2 - 0.033 14.0 0.1 0.085 12.6 0.1 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family Tissue_fac PF01108.15 MSTRG.24784.1_2 - 0.046 13.4 0.1 0.11 12.2 0.1 1.5 1 0 0 1 1 1 0 Tissue factor YukC PF10140.7 MSTRG.24784.1_2 - 0.084 11.5 0.1 0.17 10.5 0.1 1.4 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC TBPIP PF07106.11 MSTRG.24784.1_2 - 0.14 11.8 2.3 0.32 10.6 2.3 1.6 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) PMP22_Claudin PF00822.18 MSTRG.14946.1_2 - 2.8e-30 105.2 9.1 3.5e-30 104.9 9.1 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family TMEM37 PF15108.4 MSTRG.14946.1_2 - 0.46 10.2 5.6 0.68 9.6 5.6 1.2 1 0 0 1 1 1 0 Voltage-dependent calcium channel gamma-like subunit protein family DUF872 PF05915.10 MSTRG.14946.1_2 - 3.1 7.9 5.2 2 8.5 1.4 2.5 2 1 1 3 3 3 0 Eukaryotic protein of unknown function (DUF872) TSC22 PF01166.16 MSTRG.10500.2_3 - 3.4e-26 91.2 3.4 5.5e-26 90.5 3.4 1.3 1 0 0 1 1 1 1 TSC-22/dip/bun family DUF972 PF06156.11 MSTRG.10500.2_3 - 0.0029 18.1 0.7 0.0058 17.1 0.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF972) K-box PF01486.15 MSTRG.10500.2_3 - 0.023 14.7 0.2 0.04 14.0 0.2 1.3 1 0 0 1 1 1 0 K-box region CCDC85 PF10226.7 MSTRG.10500.2_3 - 0.86 9.1 2.9 0.29 10.6 0.3 1.5 2 0 0 2 2 2 0 CCDC85 family MMS22L_N PF14910.4 MSTRG.24595.1_3 - 1.8e-97 327.4 2.7 2.1e-97 327.2 2.7 1.0 1 0 0 1 1 1 1 S-phase genomic integrity recombination mediator, N-terminal AKAP7_NLS PF10469.7 MSTRG.6881.1_2 - 2.7e-17 63.2 0.0 4e-17 62.7 0.0 1.2 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.4 MSTRG.6881.1_2 - 1.6e-06 28.0 0.1 2.7e-06 27.2 0.1 1.3 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily zf-CCCH PF00642.22 MSTRG.6881.1_2 - 7.3e-05 22.4 1.8 0.00016 21.3 1.8 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF504 PF04457.10 MSTRG.6881.1_2 - 0.0008 19.7 0.0 0.0016 18.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF504) LigT_PEase PF02834.14 MSTRG.6881.1_2 - 0.0019 18.3 0.1 0.37 10.9 0.1 2.4 2 0 0 2 2 2 1 LigT like Phosphoesterase Torus PF16131.3 MSTRG.6881.1_2 - 0.055 14.0 0.4 0.055 14.0 0.4 1.8 2 0 0 2 2 2 0 Torus domain PMM PF03332.11 MSTRG.7944.1_2 - 1.3e-101 338.8 0.5 1.6e-101 338.5 0.5 1.1 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.10 MSTRG.7944.1_2 - 5.9e-07 29.3 0.1 2e-06 27.6 0.1 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase ubiquitin PF00240.21 MSTRG.5248.1_3 - 0.00032 20.2 0.8 0.067 12.8 0.1 2.5 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.6 MSTRG.5248.1_3 - 0.011 15.5 0.1 0.033 13.9 0.1 1.9 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Y_phosphatase PF00102.25 MSTRG.10478.2_2 - 1.2e-73 247.5 0.2 1.6e-73 247.1 0.2 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.18 MSTRG.10478.2_2 - 0.00078 19.1 0.0 0.0016 18.1 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CENP-B_dimeris PF09026.8 MSTRG.10478.2_3 - 0.016 15.5 1.1 0.027 14.7 1.1 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Oscp1 PF10188.7 MSTRG.28989.1_2 - 1.2e-34 119.8 0.3 1.4e-34 119.6 0.3 1.0 1 0 0 1 1 1 1 Organic solute transport protein 1 Methyltransf_16 PF10294.7 MSTRG.17914.1_1 - 3.6e-18 65.8 0.0 5.4e-18 65.2 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.11 MSTRG.17914.1_1 - 0.0021 17.4 0.0 0.0033 16.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.12 MSTRG.17914.1_1 - 0.0025 17.3 0.0 0.0047 16.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.4 MSTRG.17914.1_1 - 0.0063 17.1 0.0 0.016 15.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 MSTRG.17914.1_1 - 0.091 13.3 0.0 0.19 12.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.18 MSTRG.17914.1_1 - 0.12 11.3 0.0 0.19 10.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase NdhM PF10664.7 MSTRG.17914.1_1 - 0.12 12.5 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 Cyanobacterial and plastid NDH-1 subunit M Tsg PF04668.10 MSTRG.21280.1_1 - 2.1e-41 141.6 3.4 2.1e-41 141.6 3.4 2.7 2 0 0 2 2 2 1 Twisted gastrulation (Tsg) protein conserved region DUF3504 PF12012.6 MSTRG.20052.1_3 - 2.2e-60 203.1 0.9 7.4e-60 201.4 0.9 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3504) Pkinase PF00069.23 MSTRG.16221.1_2 - 2.4e-75 253.2 0.0 3.4e-75 252.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.16221.1_2 - 5.8e-41 140.4 0.0 9e-41 139.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.16221.1_2 - 3.6e-08 32.9 0.0 5.5e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 MSTRG.16221.1_2 - 0.065 12.4 0.8 0.11 11.7 0.8 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LIM PF00412.20 MSTRG.14120.3_3 - 3.4e-11 43.1 5.5 6.9e-11 42.1 5.5 1.6 1 0 0 1 1 1 1 LIM domain bZIP_Maf PF03131.15 MSTRG.19091.1_3 - 3.9e-33 113.7 12.5 3.9e-33 113.7 12.5 1.6 2 0 0 2 2 1 1 bZIP Maf transcription factor bZIP_1 PF00170.19 MSTRG.19091.1_3 - 0.0002 21.2 14.7 0.0019 18.1 14.7 2.3 1 1 0 1 1 1 1 bZIP transcription factor DivIC PF04977.13 MSTRG.19091.1_3 - 0.00029 20.4 5.9 0.00029 20.4 5.9 2.3 1 1 1 2 2 2 1 Septum formation initiator DUF1192 PF06698.9 MSTRG.19091.1_3 - 0.013 15.4 4.1 0.29 11.1 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) GIT_CC PF16559.3 MSTRG.19091.1_3 - 0.029 14.3 2.0 0.06 13.3 2.0 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF3450 PF11932.6 MSTRG.19091.1_3 - 0.045 12.9 3.0 0.071 12.3 3.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) APG6 PF04111.10 MSTRG.19091.1_3 - 0.18 11.0 4.5 0.26 10.5 4.5 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 JIP_LZII PF16471.3 MSTRG.19091.1_3 - 0.28 11.3 7.0 0.045 13.8 2.2 1.9 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II DUF342 PF03961.11 MSTRG.19091.1_3 - 0.3 9.5 2.6 0.42 9.0 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) HAUS-augmin3 PF14932.4 MSTRG.19091.1_3 - 0.42 9.9 7.0 0.59 9.5 7.0 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Cnn_1N PF07989.9 MSTRG.19091.1_3 - 0.59 10.2 10.5 0.25 11.3 7.4 2.0 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 bZIP_2 PF07716.13 MSTRG.19091.1_3 - 0.73 9.8 15.4 0.77 9.8 13.1 2.3 1 1 1 2 2 2 0 Basic region leucine zipper Prominin PF05478.9 MSTRG.19091.1_3 - 0.95 7.2 4.5 1.3 6.7 4.5 1.0 1 0 0 1 1 1 0 Prominin Spc24 PF08286.9 MSTRG.19091.1_3 - 1.1 9.5 4.7 0.3 11.2 1.5 1.6 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Bap31 PF05529.10 MSTRG.19091.1_3 - 1.1 8.7 5.1 1.7 8.1 5.1 1.3 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like DUF972 PF06156.11 MSTRG.19091.1_3 - 1.1 9.7 6.9 0.44 11.1 2.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF972) IncA PF04156.12 MSTRG.19091.1_3 - 2.6 7.7 9.4 7 6.3 9.4 1.7 1 1 0 1 1 1 0 IncA protein LRR_8 PF13855.4 MSTRG.25885.2_3 - 5.1e-18 64.5 22.2 7e-10 38.4 1.8 4.4 1 1 4 5 5 5 5 Leucine rich repeat LRR_4 PF12799.5 MSTRG.25885.2_3 - 2.2e-16 59.5 18.7 1.8e-05 24.8 3.2 5.0 2 1 3 5 5 5 5 Leucine Rich repeats (2 copies) CH PF00307.29 MSTRG.25885.2_3 - 9.1e-09 35.3 0.0 1.8e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 MSTRG.25885.2_3 - 0.055 13.2 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 CAMSAP CH domain LRR_9 PF14580.4 MSTRG.25885.2_3 - 0.29 10.5 5.3 2.8 7.3 0.7 2.6 1 1 2 3 3 3 0 Leucine-rich repeat LRR_1 PF00560.31 MSTRG.25885.2_3 - 5.8 7.7 24.2 33 5.4 0.2 8.0 8 0 0 8 8 8 0 Leucine Rich Repeat Sulfate_transp PF00916.18 MSTRG.19100.1_3 - 0.00043 19.0 0.2 0.00075 18.2 0.2 1.4 1 0 0 1 1 1 1 Sulfate permease family A2M_comp PF07678.12 MSTRG.27288.1_3 - 7.6e-56 189.2 0.0 1.1e-55 188.7 0.0 1.2 1 0 0 1 1 1 1 A-macroglobulin complement component A2M_recep PF07677.12 MSTRG.27288.1_3 - 1.5e-23 83.2 1.4 3.4e-23 82.1 1.4 1.6 1 0 0 1 1 1 1 A-macroglobulin receptor YqhG PF11079.6 MSTRG.27288.1_3 - 0.032 13.1 0.0 0.052 12.4 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein YqhG of unknown function SQHop_cyclase_C PF13243.4 MSTRG.27288.1_3 - 0.075 12.0 0.2 4.1 6.3 0.1 2.2 1 1 1 2 2 2 0 Squalene-hopene cyclase C-terminal domain Carn_acyltransf PF00755.18 MSTRG.7904.2_3 - 4.1e-168 560.5 0.0 4.6e-168 560.3 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Cadherin_tail PF15974.3 MSTRG.10369.1_2 - 4.3e-57 192.0 3.8 7.8e-57 191.2 3.8 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region JmjC PF02373.20 MSTRG.24491.5_1 - 1.2e-31 109.4 2.5 3.6e-31 107.8 2.5 1.9 1 0 0 1 1 1 1 JmjC domain, hydroxylase MIP-T3 PF10243.7 MSTRG.24491.5_1 - 0.00013 20.7 50.2 0.00013 20.7 50.2 3.7 3 0 0 3 3 3 2 Microtubule-binding protein MIP-T3 DSPc PF00782.18 MSTRG.1219.3_1 - 0.00015 21.4 0.0 0.00027 20.6 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 MSTRG.1219.3_1 - 0.015 14.8 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase zf-C2H2_2 PF12756.5 MSTRG.9974.5_2 - 2.5 8.4 14.4 0.4 10.9 2.4 3.3 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.6 MSTRG.9974.5_2 - 2.6 8.3 10.1 0.42 10.9 4.2 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Actin_micro PF17003.3 MSTRG.9974.5_3 - 0.028 13.5 0.3 0.043 12.9 0.3 1.2 1 0 0 1 1 1 0 Putative actin-like family WD40 PF00400.30 MSTRG.10361.1_2 - 3.5e-38 128.8 17.7 4e-06 27.3 0.1 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat Beta-TrCP_D PF12125.6 MSTRG.10361.1_2 - 3.1e-24 84.4 0.6 6.9e-24 83.3 0.6 1.6 1 0 0 1 1 1 1 D domain of beta-TrCP ANAPC4_WD40 PF12894.5 MSTRG.10361.1_2 - 9.3e-10 38.5 2.5 0.056 13.6 0.1 4.4 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.5 MSTRG.10361.1_2 - 9.9e-09 34.8 0.1 2.6e-08 33.5 0.1 1.7 1 0 0 1 1 1 1 F-box-like WD40_like PF17005.3 MSTRG.10361.1_2 - 2.7e-06 26.8 0.1 0.0034 16.6 0.2 2.2 1 1 1 2 2 2 2 WD40-like domain F-box PF00646.31 MSTRG.10361.1_2 - 7e-06 25.6 0.0 2.1e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.6 MSTRG.10361.1_2 - 0.00051 18.7 6.4 0.51 8.8 0.1 3.8 2 2 2 4 4 4 2 Nucleoporin Nup120/160 DUF5046 PF16465.3 MSTRG.10361.1_2 - 0.17 11.2 0.2 25 4.0 0.1 3.2 1 1 3 4 4 4 0 Domain of unknown function (DUF5046) T-box PF00907.20 MSTRG.5647.1_1 - 1.3e-44 152.5 0.1 2.1e-44 151.8 0.1 1.2 1 0 0 1 1 1 1 T-box DUF1388 PF07142.10 MSTRG.5647.1_1 - 0.039 13.8 0.2 0.28 11.0 0.1 2.6 2 0 0 2 2 2 0 Repeat of unknown function (DUF1388) CDC45 PF02724.12 MSTRG.6899.1_1 - 8.6 4.4 10.5 11 4.0 10.5 1.1 1 0 0 1 1 1 0 CDC45-like protein AAA_11 PF13086.4 MSTRG.6899.1_2 - 0.73 9.4 8.9 1.7 8.2 8.9 1.7 1 0 0 1 1 1 0 AAA domain VSG_B PF13206.4 MSTRG.6899.1_2 - 2.7 7.0 15.2 5.3 6.1 15.2 1.4 1 0 0 1 1 1 0 Trypanosomal VSG domain TIR PF01582.18 MSTRG.17502.1_2 - 6.3e-17 61.8 0.0 8.2e-17 61.4 0.0 1.1 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.4 MSTRG.17502.1_2 - 0.00015 21.9 0.0 0.00025 21.2 0.0 1.3 1 0 0 1 1 1 1 TIR domain Filament PF00038.19 MSTRG.19050.1_2 - 5.9e-113 377.4 42.3 8.6e-113 376.9 42.3 1.2 1 0 0 1 1 1 1 Intermediate filament protein Filament_head PF04732.12 MSTRG.19050.1_2 - 7.5e-12 45.8 18.1 7.5e-12 45.8 18.1 2.6 2 0 0 2 2 2 1 Intermediate filament head (DNA binding) region CENP-F_leu_zip PF10473.7 MSTRG.19050.1_2 - 0.0046 16.8 8.9 0.0046 16.8 8.9 3.3 1 1 2 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IncA PF04156.12 MSTRG.19050.1_2 - 0.0055 16.4 41.0 0.27 10.9 11.3 3.5 1 1 1 3 3 3 3 IncA protein DUF972 PF06156.11 MSTRG.19050.1_2 - 0.17 12.4 21.1 8.2 7.0 1.0 5.5 1 1 4 5 5 5 0 Protein of unknown function (DUF972) Taxilin PF09728.7 MSTRG.19050.1_2 - 0.3 10.2 36.4 0.013 14.7 30.4 1.7 2 0 0 2 2 2 0 Myosin-like coiled-coil protein TPR_MLP1_2 PF07926.10 MSTRG.19050.1_2 - 0.68 9.9 41.9 0.6 10.0 9.0 5.4 2 1 4 6 6 6 0 TPR/MLP1/MLP2-like protein DUF1664 PF07889.10 MSTRG.19050.1_2 - 0.75 9.7 18.9 0.016 15.1 2.3 3.8 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) Golgin_A5 PF09787.7 MSTRG.19050.1_2 - 1.1 8.5 32.7 0.24 10.7 11.4 2.5 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF573 PF04504.12 MSTRG.19050.1_2 - 1.2 9.8 6.0 0.73 10.4 0.2 3.2 2 2 1 3 3 3 0 Protein of unknown function, DUF573 RNR_N PF08343.8 MSTRG.19050.1_2 - 2.4 8.1 8.5 0.45 10.5 1.5 3.0 3 0 0 3 3 3 0 Ribonucleotide reductase N-terminal TolA_bind_tri PF16331.3 MSTRG.19050.1_2 - 3.5 7.6 37.7 0.032 14.2 4.6 5.2 4 2 2 6 6 5 0 TolA binding protein trimerisation Prefoldin PF02996.15 MSTRG.19050.1_2 - 4 7.3 21.9 0.091 12.5 1.9 4.4 4 0 0 4 4 4 0 Prefoldin subunit COBRA1 PF06209.11 MSTRG.26859.1_2 - 1.1e-232 772.8 6.1 1.5e-232 772.4 6.1 1.1 1 0 0 1 1 1 1 Cofactor of BRCA1 (COBRA1) MRVI1 PF05781.10 MSTRG.23500.7_3 - 8.1e-14 51.1 0.0 2.1e-13 49.7 0.0 1.6 2 0 0 2 2 2 1 MRVI1 protein DUF3040 PF11239.6 MSTRG.23500.7_3 - 0.11 12.6 1.1 0.23 11.6 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) WD40 PF00400.30 MSTRG.21803.1_2 - 2.7e-10 40.5 4.0 0.00032 21.3 0.1 4.7 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.21803.1_2 - 0.0012 18.9 0.1 0.13 12.5 0.0 3.3 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain 2-oxoacid_dh PF00198.21 MSTRG.22080.1_1 - 1.8e-74 250.0 0.0 2.4e-74 249.6 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.20 MSTRG.22080.1_1 - 2.7e-20 71.9 0.7 4.8e-20 71.0 0.7 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.15 MSTRG.22080.1_1 - 1.2e-09 38.2 0.2 2.3e-09 37.3 0.2 1.5 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.4 MSTRG.22080.1_1 - 0.0091 15.7 0.0 0.093 12.5 0.0 2.4 1 1 1 2 2 2 1 Biotin-lipoyl like XRN_N PF03159.16 MSTRG.7066.1_3 - 3.6e-95 317.8 0.0 6.7e-95 317.0 0.0 1.5 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus Lipocalin PF00061.21 MSTRG.9962.2_2 - 1.4e-25 90.1 2.5 1.9e-25 89.6 2.5 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 MSTRG.9962.2_2 - 4.2e-09 36.3 1.2 6.5e-09 35.7 1.2 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Calpain_III PF01067.20 MSTRG.17973.1_3 - 5.8e-14 52.4 0.0 1.2e-13 51.4 0.0 1.5 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_6 PF13405.4 MSTRG.17973.1_3 - 0.0039 16.9 0.0 0.024 14.4 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.30 MSTRG.17973.1_3 - 0.034 13.6 0.0 0.096 12.2 0.0 1.8 1 0 0 1 1 1 0 EF hand MutL_C PF08676.9 MSTRG.25275.1_2 - 9.5e-14 51.3 0.1 1.8e-12 47.1 0.1 2.4 1 1 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.17 MSTRG.25275.1_2 - 1e-09 37.9 0.0 3e-08 33.2 0.0 2.4 1 1 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.4 MSTRG.25275.1_2 - 6.9e-08 32.3 0.1 2e-07 30.8 0.1 1.7 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.24 MSTRG.25275.1_2 - 5.6e-07 30.0 0.0 2.4e-06 28.0 0.0 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase I-set PF07679.14 MSTRG.28649.1_2 - 5.8e-11 42.2 0.4 8e-05 22.5 0.0 2.1 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.28649.1_2 - 0.00026 21.4 0.1 0.23 12.0 0.0 2.3 1 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.28649.1_2 - 0.01 16.0 0.0 0.97 9.7 0.0 2.1 1 1 1 2 2 2 0 Immunoglobulin domain ig PF00047.23 MSTRG.28649.1_2 - 0.015 15.3 0.1 0.75 9.9 0.0 2.1 2 0 0 2 2 2 0 Immunoglobulin domain V-set PF07686.15 MSTRG.28649.1_2 - 0.042 13.9 0.0 2.3 8.3 0.0 2.1 2 0 0 2 2 2 0 Immunoglobulin V-set domain Ist1 PF03398.12 MSTRG.5872.3_3 - 1.1e-61 207.4 3.9 1.4e-61 207.0 3.9 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway zf-C2H2 PF00096.24 MSTRG.17194.1_3 - 2.6e-27 93.6 57.4 4.5e-06 26.7 0.1 8.6 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.17194.1_3 - 2.7e-22 77.4 57.0 0.0015 19.0 0.8 8.5 8 0 0 8 8 8 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.17194.1_3 - 2.2e-18 65.6 50.5 1.4e-05 24.7 2.7 8.2 8 0 0 8 8 8 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.17194.1_3 - 1.7e-14 53.6 34.4 0.0003 20.9 0.0 8.0 8 0 0 8 8 7 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.17194.1_3 - 3.3e-08 33.5 32.0 0.065 13.5 0.1 7.4 8 0 0 8 8 8 5 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.4 MSTRG.17194.1_3 - 1.1e-07 31.8 57.1 0.015 15.6 1.6 8.8 9 0 0 9 9 8 5 Zinc-finger double domain zf-C2H2_8 PF15909.3 MSTRG.17194.1_3 - 2.8e-05 24.2 10.4 2.8e-05 24.2 10.4 4.2 2 2 2 4 4 4 1 C2H2-type zinc ribbon Rad50_zn_hook PF04423.12 MSTRG.17194.1_3 - 0.038 13.7 8.3 1.2 8.9 0.1 3.9 4 0 0 4 4 4 0 Rad50 zinc hook motif ADK_lid PF05191.12 MSTRG.17194.1_3 - 0.091 12.7 10.1 3 7.8 0.1 4.7 3 2 3 6 6 6 0 Adenylate kinase, active site lid zf-C2HC_2 PF13913.4 MSTRG.17194.1_3 - 0.28 11.0 0.0 0.28 11.0 0.0 6.1 7 0 0 7 7 7 0 zinc-finger of a C2HC-type CpXC PF14353.4 MSTRG.17194.1_3 - 0.99 9.3 31.1 1.7 8.6 0.7 5.9 4 2 1 5 5 5 0 CpXC protein AT_hook PF02178.17 MSTRG.17194.1_3 - 1.1 9.2 9.8 0.16 11.8 1.4 3.0 2 0 0 2 2 2 0 AT hook motif zf-C2H2_2 PF12756.5 MSTRG.17194.1_3 - 5.8 7.2 44.0 22 5.3 2.8 7.7 2 2 4 6 6 6 0 C2H2 type zinc-finger (2 copies) Phage_TAC_6 PF09550.8 MSTRG.5205.1_2 - 0.057 13.7 1.5 0.094 13.0 1.5 1.3 1 0 0 1 1 1 0 Phage tail assembly chaperone protein, TAC TLE_N PF03920.13 MSTRG.16867.1_3 - 2.3e-72 241.0 8.5 3.4e-72 240.5 8.5 1.2 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain HALZ PF02183.16 MSTRG.16867.1_3 - 0.018 15.1 0.1 0.036 14.1 0.1 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper HAP1_N PF04849.11 MSTRG.16867.1_3 - 0.049 12.7 3.1 0.096 11.7 3.1 1.5 1 0 0 1 1 1 0 HAP1 N-terminal conserved region SKA2 PF16740.3 MSTRG.16867.1_3 - 4.3 7.0 6.9 2.1 8.0 4.0 1.9 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 MIP-T3 PF10243.7 MSTRG.16867.1_3 - 6.5 5.2 17.1 9.4 4.7 17.1 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Ras PF00071.20 MSTRG.21100.1_3 - 1.5e-21 76.5 0.0 1.9e-21 76.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.21100.1_3 - 0.00043 20.4 0.0 0.00061 19.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase CagD PF16567.3 MSTRG.21100.1_3 - 0.11 12.2 0.0 0.15 11.7 0.0 1.1 1 0 0 1 1 1 0 Pathogenicity island component CagD DUF2152 PF10222.7 MSTRG.20504.3_1 - 2.2e-185 617.4 0.0 2.7e-185 617.1 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2152) DUF2152 PF10222.7 MSTRG.20504.3_3 - 0.15 10.2 0.0 0.2 9.8 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2152) SET PF00856.26 MSTRG.1244.1_3 - 7.5e-22 78.4 3.5 1.1e-21 77.8 0.4 2.7 2 1 0 2 2 2 1 SET domain PWWP PF00855.15 MSTRG.1244.1_3 - 5.9e-17 61.8 0.1 2.8e-16 59.6 0.1 2.3 1 0 0 1 1 1 1 PWWP domain PHD PF00628.27 MSTRG.1244.1_3 - 8.9e-10 38.2 70.9 8e-07 28.7 9.6 7.1 3 2 2 6 6 6 3 PHD-finger zf-HC5HC2H_2 PF13832.4 MSTRG.1244.1_3 - 0.0059 16.6 1.9 0.0059 16.6 1.9 6.5 4 2 2 7 7 7 3 PHD-zinc-finger like domain zf-HC5HC2H PF13771.4 MSTRG.1244.1_3 - 1.2 9.3 77.5 0.18 11.9 0.6 6.9 4 2 2 6 6 6 0 PHD-like zinc-binding domain Ephrin_rec_like PF07699.11 MSTRG.25936.1_1 - 7e-25 86.4 13.1 6.6e-15 54.5 5.7 2.9 3 0 0 3 3 3 2 Putative ephrin-receptor like EGF PF00008.25 MSTRG.25936.1_1 - 4.1e-06 26.8 8.5 4.1e-06 26.8 8.5 2.6 3 0 0 3 3 3 1 EGF-like domain hEGF PF12661.5 MSTRG.25936.1_1 - 4.6e-05 23.8 5.5 4.6e-05 23.8 5.5 3.0 2 0 0 2 2 2 1 Human growth factor-like EGF EGF_3 PF12947.5 MSTRG.25936.1_1 - 0.0087 16.1 2.8 0.0087 16.1 2.8 2.0 2 0 0 2 2 2 1 EGF domain EGF_2 PF07974.11 MSTRG.25936.1_1 - 0.031 14.5 6.2 0.031 14.5 6.2 3.3 4 1 0 4 4 4 0 EGF-like domain EGF_CA PF07645.13 MSTRG.25936.1_1 - 0.06 13.4 5.9 0.06 13.4 5.9 3.1 3 2 0 3 3 3 0 Calcium-binding EGF domain Plasmod_Pvs28 PF06247.9 MSTRG.25936.1_1 - 0.28 11.4 5.6 0.27 11.5 3.9 1.9 2 0 0 2 2 2 0 Pvs28 EGF domain Aconitase PF00330.18 MSTRG.440.1_3 - 1.2e-156 522.2 0.0 1.7e-156 521.7 0.0 1.2 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.17 MSTRG.440.1_3 - 3.1e-43 147.1 0.0 5.7e-43 146.3 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Rap1-DNA-bind PF09197.8 MSTRG.8413.2_2 - 0.064 13.7 2.4 0.086 13.3 2.4 1.2 1 0 0 1 1 1 0 Rap1, DNA-binding fn3 PF00041.19 MSTRG.8413.2_3 - 5.2e-20 71.5 1.2 6.6e-15 55.1 0.4 2.1 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 MSTRG.8413.2_3 - 1.5e-05 25.3 2.7 0.027 14.9 1.3 2.7 2 1 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 MSTRG.8413.2_3 - 5.1e-05 23.4 0.0 0.0076 16.4 0.0 2.1 1 1 1 2 2 2 2 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.7 MSTRG.8413.2_3 - 0.00052 20.3 0.0 1.1 9.6 0.0 2.2 2 0 0 2 2 2 2 Uncharacterised conserved protein (DUF2369) DUF11 PF01345.16 MSTRG.8413.2_3 - 0.0079 16.3 3.4 0.64 10.2 3.4 2.3 1 1 0 1 1 1 1 Domain of unknown function DUF11 DUF4998 PF16389.3 MSTRG.8413.2_3 - 0.0082 15.6 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function Ldl_recept_b PF00058.15 MSTRG.8413.2_3 - 0.14 12.5 0.0 0.3 11.5 0.0 1.6 1 0 0 1 1 1 0 Low-density lipoprotein receptor repeat class B CARDB PF07705.9 MSTRG.8413.2_3 - 0.19 11.9 3.0 0.78 9.9 0.2 2.4 2 1 0 2 2 2 0 CARDB Glutaredoxin PF00462.22 MSTRG.8455.1_3 - 2.4e-20 72.4 0.1 5e-20 71.3 0.1 1.6 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.4 MSTRG.8455.1_3 - 3.3e-05 23.7 0.1 8e-05 22.5 0.1 1.6 1 0 0 1 1 1 1 Thioredoxin domain DSBA PF01323.18 MSTRG.8455.1_3 - 0.0012 18.6 0.2 0.42 10.2 0.0 2.2 1 1 1 2 2 2 2 DSBA-like thioredoxin domain Thioredoxin PF00085.18 MSTRG.8455.1_3 - 0.0024 17.7 0.1 0.0042 16.9 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.4 MSTRG.8455.1_3 - 0.0053 17.1 0.3 0.02 15.2 0.3 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_4 PF13462.4 MSTRG.8455.1_3 - 0.078 13.0 0.8 12 5.9 0.8 2.2 1 1 0 2 2 2 0 Thioredoxin Forkhead PF00250.16 MSTRG.3502.1_3 - 7.5e-13 48.5 0.0 1.1e-12 48.0 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain HSP90 PF00183.16 MSTRG.24118.4_3 - 7.8e-99 331.7 3.8 4.3e-94 316.1 0.8 2.0 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.4 MSTRG.24118.4_3 - 1.2e-09 38.0 0.1 2.5e-09 36.9 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.24 MSTRG.24118.4_3 - 3.6e-06 27.4 0.1 6.3e-06 26.6 0.1 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Wtap PF17098.3 MSTRG.24118.4_3 - 0.033 14.0 1.0 0.064 13.1 1.0 1.4 1 0 0 1 1 1 0 WTAP/Mum2p family Sulfotransfer_1 PF00685.25 MSTRG.2573.1_3 - 6.2e-41 140.5 0.0 8.9e-41 140.0 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 MSTRG.2573.1_3 - 4.4e-16 59.8 0.0 1.3e-10 42.0 0.0 2.3 1 1 1 2 2 2 2 Sulfotransferase family KCNQ_channel PF03520.12 MSTRG.13185.1_3 - 1.2e-45 155.6 0.1 1.3e-45 155.4 0.1 1.0 1 0 0 1 1 1 1 KCNQ voltage-gated potassium channel GATase1_like PF07090.9 MSTRG.13185.1_3 - 0.02 14.3 0.0 0.022 14.1 0.0 1.0 1 0 0 1 1 1 0 Putative glutamine amidotransferase RVT_1 PF00078.25 MSTRG.8262.1_1 - 0.0084 15.5 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) V-set PF07686.15 MSTRG.8262.1_3 - 0.00052 20.0 0.0 0.00095 19.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 MSTRG.8262.1_3 - 0.053 13.6 0.1 0.23 11.5 0.0 2.1 3 0 0 3 3 3 0 Immunoglobulin domain Rhodanese PF00581.18 MSTRG.15832.1_3 - 2.2e-13 50.5 0.0 2.9e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain Sarcoglycan_1 PF04790.11 MSTRG.25705.1_1 - 1.6e-76 257.0 0.0 2.6e-76 256.3 0.0 1.3 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein DUF2345 PF10106.7 MSTRG.25705.1_1 - 0.044 13.6 0.0 0.17 11.6 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2345) RhoGAP PF00620.25 MSTRG.2799.1_1 - 4.1e-40 137.0 0.3 4.1e-40 137.0 0.3 2.4 3 0 0 3 3 3 1 RhoGAP domain TUSC2 PF15000.4 MSTRG.26964.1_3 - 2.8e-44 149.8 0.0 4.3e-44 149.2 0.0 1.3 1 0 0 1 1 1 1 Tumour suppressor candidate 2 MITF_TFEB_C_3_N PF15951.3 MSTRG.13859.2_1 - 6.6e-61 205.3 11.5 6.6e-61 205.3 11.5 2.2 2 0 0 2 2 2 1 MITF/TFEB/TFEC/TFE3 N-terminus DUF3371 PF11851.6 MSTRG.13859.2_1 - 4e-34 118.2 18.1 4e-34 118.2 18.1 3.2 2 1 0 2 2 2 1 Domain of unknown function (DUF3371) HLH PF00010.24 MSTRG.13859.2_1 - 1.6e-15 56.6 0.6 3.3e-15 55.6 0.6 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain RIH_assoc PF08454.9 MSTRG.14099.1_2 - 5.4e-32 109.5 8.6 5.6e-32 109.5 7.4 1.6 2 0 0 2 2 2 1 RyR and IP3R Homology associated Pkinase PF00069.23 MSTRG.4610.1_3 - 1.1e-34 119.9 0.0 1.7e-34 119.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.4610.1_3 - 3.1e-16 59.3 0.0 4.6e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.4610.1_3 - 2.1e-05 23.8 0.5 0.0037 16.5 0.0 2.4 2 1 0 2 2 2 2 Kinase-like Pentapeptide PF00805.20 MSTRG.2953.1_3 - 2.9e-37 125.7 25.7 4e-12 45.4 1.9 4.6 3 1 1 4 4 4 4 Pentapeptide repeats (8 copies) BTB_2 PF02214.20 MSTRG.2953.1_3 - 9.3e-20 70.7 0.0 2.5e-19 69.3 0.0 1.7 2 0 0 2 2 2 1 BTB/POZ domain Pentapeptide_4 PF13599.4 MSTRG.2953.1_3 - 7.5e-19 67.5 1.3 2.4e-09 37.1 0.0 3.5 2 1 2 4 4 4 3 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.4 MSTRG.2953.1_3 - 8e-14 51.4 0.0 3.2e-05 23.9 0.0 4.6 2 1 2 4 4 4 4 Pentapeptide repeats (9 copies) BTB_3 PF16017.3 MSTRG.2953.1_3 - 5.5e-05 23.1 0.0 0.0001 22.2 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.29 MSTRG.2953.1_3 - 0.00013 22.1 0.0 0.00022 21.3 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain WD40 PF00400.30 MSTRG.3181.2_1 - 1.3e-40 136.4 20.3 5.6e-08 33.2 0.0 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.3181.2_1 - 2.6e-13 50.0 0.0 0.0013 18.8 0.0 5.4 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 MSTRG.3181.2_1 - 0.00023 20.5 0.0 0.0024 17.1 0.0 2.1 1 1 1 2 2 2 2 WD40-like domain Myc-LZ PF02344.13 MSTRG.3181.2_1 - 0.085 12.8 2.4 0.19 11.7 2.4 1.6 1 0 0 1 1 1 0 Myc leucine zipper domain CALM_bind PF16025.3 MSTRG.3181.2_1 - 0.11 12.9 2.3 0.33 11.3 1.7 1.9 2 0 0 2 2 2 0 Calcium-dependent calmodulin binding DUF4407 PF14362.4 MSTRG.3181.2_1 - 0.66 9.1 2.1 0.99 8.6 2.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Sam68-YY PF16568.3 MSTRG.7682.1_1 - 3.3e-14 53.2 30.5 6.1e-14 52.4 30.5 1.4 1 0 0 1 1 1 1 Tyrosine-rich domain of Sam68 KH_1 PF00013.27 MSTRG.7682.1_1 - 2.2e-08 33.6 0.0 4e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 KH domain NAD_binding_4 PF07993.10 MSTRG.15214.2_1 - 2e-77 259.7 0.0 2.6e-77 259.4 0.0 1.1 1 0 0 1 1 1 1 Male sterility protein Sterile PF03015.17 MSTRG.15214.2_1 - 5e-37 125.9 0.4 1e-36 124.9 0.4 1.6 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.19 MSTRG.15214.2_1 - 6.2e-07 29.0 0.0 1e-05 25.0 0.0 2.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.17 MSTRG.15214.2_1 - 2.6e-05 23.2 0.1 0.0044 15.9 0.1 2.8 2 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.13 MSTRG.15214.2_1 - 2.6e-05 23.4 0.0 9.8e-05 21.5 0.0 1.9 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.3 MSTRG.15214.2_1 - 2.8e-05 23.5 0.0 7.2e-05 22.2 0.0 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Semialdhyde_dh PF01118.22 MSTRG.15214.2_1 - 0.0036 17.6 0.0 0.0071 16.6 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain SNF2_N PF00176.21 MSTRG.25992.4_2 - 5.3e-72 242.3 0.8 5.3e-72 242.3 0.8 2.0 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.29 MSTRG.25992.4_2 - 2.2e-20 72.9 1.0 2.7e-19 69.5 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HSA PF07529.11 MSTRG.25992.4_2 - 1e-19 70.5 18.0 1e-19 70.5 18.0 3.6 2 0 0 2 2 2 1 HSA Bromodomain PF00439.23 MSTRG.25992.4_2 - 1.1e-18 66.9 0.1 5.3e-18 64.8 0.1 2.1 2 0 0 2 2 2 1 Bromodomain SnAC PF14619.4 MSTRG.25992.4_2 - 1.3e-17 64.1 7.7 1.3e-17 64.1 7.7 5.5 5 1 0 5 5 5 1 Snf2-ATP coupling, chromatin remodelling complex BRK PF07533.14 MSTRG.25992.4_2 - 5.8e-17 60.9 0.1 1.1e-16 60.0 0.1 1.5 1 0 0 1 1 1 1 BRK domain QLQ PF08880.9 MSTRG.25992.4_2 - 4.4e-14 51.8 5.9 9.8e-14 50.7 5.9 1.7 1 0 0 1 1 1 1 QLQ ResIII PF04851.13 MSTRG.25992.4_2 - 7.7e-10 38.9 2.7 2.4e-09 37.3 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.27 MSTRG.25992.4_2 - 0.0028 17.3 0.0 0.0081 15.8 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2009 PF09418.8 MSTRG.25992.4_2 - 1.7 7.5 13.0 0.66 8.9 10.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2009) RhoGEF PF00621.18 MSTRG.8947.2_2 - 2.9e-05 24.3 0.2 3.5e-05 24.0 0.2 1.1 1 0 0 1 1 1 1 RhoGEF domain DUF2844 PF11005.6 MSTRG.8947.2_2 - 0.063 13.2 0.0 0.098 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2844) FYVE PF01363.19 MSTRG.21210.1_2 - 1.5e-31 108.2 23.6 5.3e-17 61.6 8.6 3.8 4 0 0 4 4 4 2 FYVE zinc finger AIG1 PF04548.14 MSTRG.21210.1_2 - 0.097 11.8 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 AIG1 family C2-set_2 PF08205.10 MSTRG.22739.1_3 - 2.2e-07 30.7 0.1 4.3e-07 29.8 0.1 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain I-set PF07679.14 MSTRG.22739.1_3 - 4.6e-07 29.7 0.5 0.017 15.1 0.0 2.4 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.22739.1_3 - 1.3e-05 25.6 0.5 0.0052 17.2 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain C1-set PF07654.13 MSTRG.22739.1_3 - 0.00029 21.1 0.1 0.00072 19.8 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin C1-set domain CD34_antigen PF06365.10 MSTRG.22739.1_3 - 0.035 13.6 0.0 0.06 12.8 0.0 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family Crystall PF00030.17 MSTRG.19611.1_1 - 8.5e-36 121.9 0.4 9.8e-29 99.3 0.3 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin p450 PF00067.20 MSTRG.1168.5_1 - 2e-91 307.0 0.0 4.3e-75 253.1 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 PTR2 PF00854.19 MSTRG.1168.5_3 - 9.6e-21 73.9 2.7 9.6e-21 73.9 2.7 1.6 2 0 0 2 2 2 1 POT family dNK PF01712.17 MSTRG.13299.1_1 - 7.2e-30 104.2 0.0 1e-29 103.7 0.0 1.2 1 0 0 1 1 1 1 Deoxynucleoside kinase Cytidylate_kin PF02224.16 MSTRG.13299.1_1 - 0.028 14.0 0.0 0.046 13.3 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase TsaE PF02367.15 MSTRG.13299.1_1 - 0.067 13.1 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE KIND PF16474.3 MSTRG.23268.5_3 - 2.8e-48 164.2 0.4 5.2e-48 163.4 0.4 1.5 1 0 0 1 1 1 1 Kinase non-catalytic C-lobe domain FYVE PF01363.19 MSTRG.23268.5_3 - 0.00038 20.4 3.5 0.001 19.0 3.5 1.7 1 1 0 1 1 1 1 FYVE zinc finger C1_2 PF03107.14 MSTRG.23268.5_3 - 1.4 9.1 6.1 3.7 7.8 6.1 1.7 1 0 0 1 1 1 0 C1 domain TFIIE-A_C PF11521.6 MSTRG.23268.5_3 - 8.2 6.7 8.5 0.45 10.7 0.3 2.5 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha STAT_bind PF02864.13 MSTRG.14071.1_1 - 8e-70 235.4 2.1 1.4e-69 234.7 2.1 1.4 1 0 0 1 1 1 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 MSTRG.14071.1_1 - 1.4e-46 158.4 9.2 1.4e-46 158.4 9.2 2.2 2 0 0 2 2 2 1 STAT protein, all-alpha domain STAT_int PF02865.15 MSTRG.14071.1_1 - 2e-35 121.8 5.8 5.3e-35 120.4 5.8 1.8 1 0 0 1 1 1 1 STAT protein, protein interaction domain SH2 PF00017.22 MSTRG.14071.1_1 - 6.5e-09 35.6 0.0 1.9e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 SH2 domain Phage_sheath_1 PF04984.12 MSTRG.14071.1_1 - 0.029 12.9 0.0 0.044 12.3 0.0 1.2 1 0 0 1 1 1 0 Phage tail sheath protein ACBP PF00887.17 MSTRG.29770.1_3 - 0.065 13.3 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Acyl CoA binding protein PRIMA1 PF16101.3 MSTRG.29770.1_3 - 1.4 8.9 11.4 5.4 6.9 7.1 2.2 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 CARD PF00619.19 MSTRG.9985.1_2 - 5e-12 45.6 0.3 7.1e-12 45.1 0.3 1.2 1 0 0 1 1 1 1 Caspase recruitment domain SNase PF00565.15 MSTRG.15311.1_2 - 3e-65 217.3 0.0 4.4e-14 52.7 0.0 5.6 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.22 MSTRG.15311.1_2 - 2.8e-26 91.8 0.0 6.3e-26 90.7 0.0 1.6 1 0 0 1 1 1 1 Tudor domain SR-25 PF10500.7 MSTRG.22967.1_3 - 1.6 8.1 11.4 2.2 7.7 11.4 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein p450 PF00067.20 MSTRG.8181.1_2 - 5.7e-27 94.4 0.0 6.1e-27 94.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 MMR_HSR1 PF01926.21 MSTRG.15103.4_1 - 1e-14 54.4 0.0 4.5e-12 45.9 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.16 MSTRG.15103.4_1 - 2.8e-05 23.6 0.1 0.00011 21.7 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.14 MSTRG.15103.4_1 - 0.00067 19.5 0.0 0.002 17.9 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Arf PF00025.19 MSTRG.15103.4_1 - 0.02 14.2 0.4 0.72 9.2 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family NGP1NT PF08153.10 MSTRG.15103.4_3 - 2.2e-45 153.8 0.4 3.8e-45 153.1 0.4 1.3 1 0 0 1 1 1 1 NGP1NT (NUC091) domain Glutaredoxin PF00462.22 MSTRG.25668.1_1 - 5.5e-18 64.8 0.1 1.3e-17 63.6 0.0 1.7 2 0 0 2 2 2 1 Glutaredoxin C2 PF00168.28 MSTRG.24527.1_1 - 6.8e-70 231.8 0.0 6e-17 61.7 0.0 4.5 4 0 0 4 4 4 4 C2 domain FerB PF08150.10 MSTRG.24527.1_1 - 1.1e-26 93.1 0.0 2.2e-26 92.1 0.0 1.6 1 0 0 1 1 1 1 FerB (NUC096) domain FerA PF08165.9 MSTRG.24527.1_1 - 4.8e-19 67.9 0.4 1.2e-18 66.6 0.4 1.7 1 0 0 1 1 1 1 FerA (NUC095) domain FerI PF08151.10 MSTRG.24527.1_1 - 8.9e-19 67.2 0.0 1.9e-18 66.1 0.0 1.6 1 0 0 1 1 1 1 FerI (NUC094) domain PI3K_C2 PF00792.22 MSTRG.24527.1_1 - 0.042 13.8 0.0 5.8 6.8 0.0 2.7 2 0 0 2 2 2 0 Phosphoinositide 3-kinase C2 CEP76-C2 PF15627.4 MSTRG.24527.1_1 - 0.096 12.1 0.0 0.5 9.8 0.0 2.1 2 0 0 2 2 2 0 CEP76 C2 domain Pex24p PF06398.9 MSTRG.24527.1_1 - 0.65 8.8 21.3 0.008 15.1 5.7 2.8 2 1 1 3 3 3 0 Integral peroxisomal membrane peroxin zf-Di19 PF05605.10 MSTRG.21961.1_1 - 0.0005 20.2 0.1 0.002 18.3 0.1 2.0 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.4 MSTRG.21961.1_1 - 0.0021 18.6 0.6 0.015 16.0 0.6 2.6 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2HC_2 PF13913.4 MSTRG.21961.1_1 - 0.011 15.5 1.1 0.037 13.8 1.1 1.9 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zf-H2C2_5 PF13909.4 MSTRG.21961.1_1 - 0.079 12.6 3.5 0.29 10.8 3.5 2.0 1 0 0 1 1 1 0 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 MSTRG.21961.1_1 - 0.12 12.8 1.0 0.12 12.8 1.0 2.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type Actin_micro PF17003.3 MSTRG.21961.1_1 - 0.14 11.1 5.7 0.18 10.8 5.7 1.1 1 0 0 1 1 1 0 Putative actin-like family Sugar_tr PF00083.22 MSTRG.20684.3_1 - 7.4e-30 104.1 14.1 9.7e-29 100.4 14.1 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 MSTRG.20684.3_1 - 1.5e-20 73.3 28.8 1.1e-17 63.9 18.3 2.2 1 1 0 2 2 2 2 Major Facilitator Superfamily SM-ATX PF14438.4 MSTRG.1937.1_2 - 4e-21 74.8 0.0 8.8e-21 73.7 0.0 1.6 1 0 0 1 1 1 1 Ataxin 2 SM domain LsmAD PF06741.11 MSTRG.1937.1_2 - 1e-14 54.7 2.5 2.5e-14 53.5 2.5 1.7 1 0 0 1 1 1 1 LsmAD domain PAM2 PF07145.13 MSTRG.1937.1_2 - 7.2e-06 25.2 1.3 1.8e-05 24.0 1.3 1.7 1 0 0 1 1 1 1 Ataxin-2 C-terminal region CLASP_N PF12348.6 MSTRG.17743.1_3 - 3.2e-20 72.5 4.8 1.1e-12 47.9 0.0 3.1 3 0 0 3 3 3 2 CLASP N terminal RIX1 PF08167.10 MSTRG.17743.1_3 - 1e-05 25.3 0.2 0.00044 19.9 0.0 3.0 3 0 0 3 3 3 1 rRNA processing/ribosome biogenesis Vac14_Fab1_bd PF12755.5 MSTRG.17743.1_3 - 0.014 15.8 1.6 12 6.4 0.0 4.4 3 1 2 5 5 5 0 Vacuolar 14 Fab1-binding region MMS19_N PF14500.4 MSTRG.17743.1_3 - 0.088 12.2 1.8 0.2 11.1 0.4 2.3 2 1 0 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II NUC173 PF08161.10 MSTRG.17743.1_3 - 0.12 11.9 1.3 2.2 7.7 0.1 2.7 3 0 0 3 3 3 0 NUC173 domain Cnd1 PF12717.5 MSTRG.17743.1_3 - 0.22 11.4 5.6 4.9 7.0 0.6 3.4 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.20 MSTRG.17743.1_3 - 0.81 10.0 6.2 54 4.3 0.0 5.6 6 0 0 6 6 6 0 HEAT repeat DUF3361 PF11841.6 MSTRG.17743.1_3 - 7.6 6.3 6.6 7.5 6.3 1.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3361) MMR_HSR1 PF01926.21 MSTRG.7636.1_1 - 7.1e-12 45.3 0.0 3.7e-11 43.0 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.14 MSTRG.7636.1_1 - 6.4e-05 22.8 0.2 0.00096 19.0 0.2 2.2 1 1 0 1 1 1 1 Protein of unknown function, DUF258 FeoB_N PF02421.16 MSTRG.7636.1_1 - 9.9e-05 21.8 0.2 0.0015 18.0 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B TniB PF05621.9 MSTRG.7636.1_1 - 0.045 12.8 0.0 0.071 12.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein AAA_16 PF13191.4 MSTRG.7636.1_1 - 0.085 13.1 0.1 0.2 11.9 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain Dynamin_N PF00350.21 MSTRG.7636.1_1 - 0.15 12.0 0.4 1.5 8.7 0.1 2.2 1 1 1 2 2 2 0 Dynamin family Zn-ribbon_8 PF09723.8 MSTRG.26651.1_2 - 0.073 13.1 1.5 0.44 10.6 1.5 2.5 1 0 0 1 1 1 0 Zinc ribbon domain DUF3697 PF12478.6 MSTRG.5724.2_1 - 1.8e-16 59.8 2.6 1.8e-16 59.8 2.6 2.1 2 0 0 2 2 2 1 Ubiquitin-associated protein 2 DUF1296 PF06972.9 MSTRG.5724.2_1 - 0.0044 17.0 0.1 0.01 15.8 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1296) UBA_4 PF14555.4 MSTRG.5724.2_1 - 0.0053 16.4 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain API5 PF05918.9 MSTRG.5724.2_1 - 10 4.7 5.6 18 3.8 5.6 1.4 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) A_deaminase PF00962.20 MSTRG.3267.1_3 - 2.2e-129 431.4 0.2 5.2e-129 430.1 0.2 1.6 1 1 0 1 1 1 1 Adenosine/AMP deaminase DUF4662 PF15578.4 MSTRG.16992.1_3 - 1.5e-14 54.2 0.0 2e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4662) PH PF00169.27 MSTRG.23827.2_2 - 1.1e-10 41.8 0.0 1.7e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 MSTRG.23827.2_2 - 3.9e-06 27.1 0.0 7.1e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.4 MSTRG.23827.2_2 - 0.0071 16.5 0.1 0.3 11.2 0.1 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain FXMR_C2 PF16098.3 MSTRG.23827.2_2 - 0.16 12.3 0.1 0.24 11.8 0.1 1.3 1 0 0 1 1 1 0 Fragile X-related mental retardation protein C-terminal region 2 WWE PF02825.18 MSTRG.2904.1_3 - 7.1e-38 128.9 3.2 1.5e-18 67.0 1.4 2.4 2 0 0 2 2 2 2 WWE domain zf-rbx1 PF12678.5 MSTRG.2904.1_3 - 9.8e-05 22.4 0.6 0.00065 19.8 0.6 2.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.23 MSTRG.2904.1_3 - 0.00024 20.8 1.3 0.00024 20.8 1.3 3.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-UDP PF14569.4 MSTRG.2904.1_3 - 0.039 13.9 0.2 0.13 12.3 0.2 1.8 1 0 0 1 1 1 0 Zinc-binding RING-finger Cullin PF00888.20 MSTRG.22006.2_2 - 1e-200 668.3 18.0 1e-200 668.3 18.0 1.6 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.7 MSTRG.22006.2_2 - 2.3e-28 97.9 4.1 8.8e-28 96.0 3.0 2.5 2 0 0 2 2 2 1 Cullin protein neddylation domain zf-H2C2_2 PF13465.4 MSTRG.14785.1_1 - 2e-22 78.4 22.9 6e-08 32.7 0.3 5.0 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.14785.1_1 - 9.4e-20 69.8 27.7 5.6e-06 26.4 0.2 5.3 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.14785.1_1 - 1.3e-11 44.1 20.0 0.0053 17.4 2.5 5.0 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.14785.1_1 - 6.9e-05 22.6 3.2 0.054 13.3 1.0 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.5 MSTRG.14785.1_1 - 0.00017 21.7 11.5 0.0033 17.6 1.6 3.8 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.14785.1_1 - 0.0014 18.8 11.2 0.11 12.8 0.2 4.3 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding MGC-24 PF05283.9 MSTRG.14785.1_1 - 0.72 10.2 7.1 18 5.7 0.0 2.3 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin zf-H2C2_5 PF13909.4 MSTRG.14785.1_1 - 1.2 8.8 22.6 0.81 9.4 5.1 4.8 4 0 0 4 4 4 0 C2H2-type zinc-finger domain FOXP-CC PF16159.3 MSTRG.14785.1_1 - 5.8 7.5 8.9 22 5.6 0.0 3.6 2 1 2 4 4 4 0 FOXP coiled-coil domain SSF PF00474.15 MSTRG.26404.1_2 - 2e-14 53.2 3.7 3e-14 52.6 3.7 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family zf-C2H2_4 PF13894.4 MSTRG.21344.1_1 - 0.0035 17.9 3.9 0.03 15.0 3.9 2.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf-H2C2_2 PF13465.4 MSTRG.21344.1_1 - 0.043 14.2 8.0 0.16 12.4 0.2 3.1 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.21344.1_1 - 0.52 10.8 6.6 2.6 8.5 6.6 2.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-met PF12874.5 MSTRG.21344.1_1 - 1.4 9.2 16.6 0.11 12.8 4.3 3.0 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.24 MSTRG.21344.1_2 - 0.017 15.4 0.6 0.056 13.8 0.2 2.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.21344.1_2 - 0.028 14.7 0.4 0.028 14.7 0.4 1.8 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.21344.1_2 - 0.029 15.1 0.8 0.12 13.1 0.2 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.21344.1_2 - 0.06 13.2 0.1 0.15 12.0 0.1 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger BTB_2 PF02214.20 MSTRG.26567.1_2 - 4e-21 75.0 0.0 8.3e-21 74.0 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.3 MSTRG.26567.1_2 - 0.0017 18.3 0.0 0.0041 17.1 0.0 1.6 2 0 0 2 2 2 1 BTB/POZ domain zf-CCHC PF00098.21 MSTRG.11934.1_2 - 0.0041 17.0 3.8 0.0041 17.0 3.8 3.8 4 0 0 4 4 4 1 Zinc knuckle N6-adenineMlase PF10237.7 MSTRG.11934.1_2 - 0.0056 16.4 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase Sushi PF00084.18 MSTRG.7618.3_1 - 6.6e-55 183.4 48.7 7.7e-12 45.5 0.2 6.4 6 0 0 6 6 6 6 Sushi repeat (SCR repeat) DUF843 PF05814.9 MSTRG.7618.3_2 - 0.48 10.3 3.0 0.81 9.6 3.0 1.3 1 0 0 1 1 1 0 Baculovirus protein of unknown function (DUF843) ACTH_assoc PF16102.3 MSTRG.7618.3_3 - 0.15 12.8 0.5 0.31 11.8 0.5 1.6 1 0 0 1 1 1 0 ACTH-associated domain ING PF12998.5 MSTRG.16225.1_3 - 9.3e-28 96.7 3.9 1.6e-27 95.9 3.9 1.4 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.27 MSTRG.16225.1_3 - 1.3e-05 24.8 9.4 2.3e-05 24.1 9.4 1.4 1 0 0 1 1 1 1 PHD-finger DUF3684 PF12449.6 MSTRG.16225.1_3 - 0.0021 15.8 1.7 0.0028 15.4 1.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) zf-HC5HC2H_2 PF13832.4 MSTRG.16225.1_3 - 0.056 13.5 0.4 1.1 9.3 1.0 2.2 2 0 0 2 2 2 0 PHD-zinc-finger like domain PHD_2 PF13831.4 MSTRG.16225.1_3 - 0.095 12.1 4.4 0.17 11.3 4.4 1.4 1 0 0 1 1 1 0 PHD-finger zf-C4pol PF14260.4 MSTRG.16225.1_3 - 0.49 10.8 4.5 9.8 6.6 0.8 2.7 2 0 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta HTH_28 PF13518.4 MSTRG.13704.2_2 - 0.00011 22.2 0.0 0.00021 21.2 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.4 MSTRG.13704.2_2 - 0.0022 17.6 0.0 0.0047 16.6 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain Sigma70_r4_2 PF08281.10 MSTRG.13704.2_2 - 0.041 13.4 0.0 0.086 12.4 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_29 PF13551.4 MSTRG.13704.2_2 - 0.059 13.3 0.0 0.095 12.6 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix Peptidase_C48 PF02902.17 MSTRG.17602.2_1 - 5.1e-10 39.4 0.0 1.3e-09 38.1 0.0 1.7 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain zf-CCCH PF00642.22 MSTRG.12193.2_1 - 9.6e-07 28.4 4.6 0.00028 20.6 0.5 2.8 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.4 MSTRG.12193.2_1 - 0.0063 16.8 5.8 0.52 10.7 0.6 2.9 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-CCCH PF00642.22 MSTRG.12193.2_3 - 6.8e-05 22.5 12.8 0.0002 21.1 1.0 3.2 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.3 MSTRG.12193.2_3 - 0.0014 18.7 2.0 0.0061 16.7 2.0 2.0 2 0 0 2 2 2 1 Zinc-finger containing family Torus PF16131.3 MSTRG.12193.2_3 - 0.024 15.2 5.5 2.1 8.9 0.2 2.5 1 1 1 2 2 2 0 Torus domain zf-CCCH_2 PF14608.4 MSTRG.12193.2_3 - 0.57 10.6 15.0 0.52 10.7 0.9 3.1 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger ADH_zinc_N PF00107.24 MSTRG.5830.1_3 - 2e-22 79.3 0.2 3.5e-22 78.5 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 MSTRG.5830.1_3 - 2.1e-21 75.7 0.1 3.8e-21 74.9 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.3 MSTRG.5830.1_3 - 3.3e-09 36.4 0.3 7.3e-09 35.3 0.3 1.6 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.4 MSTRG.5830.1_3 - 0.0024 18.7 0.0 0.005 17.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.19 MSTRG.5830.1_3 - 0.003 16.7 2.0 0.0049 16.1 2.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ABC_trans_N PF14510.4 MSTRG.5830.1_3 - 0.017 15.5 0.0 0.038 14.4 0.0 1.5 1 0 0 1 1 1 0 ABC-transporter extracellular N-terminal PAC3 PF10178.7 MSTRG.5269.4_2 - 5.4e-29 100.0 0.0 7e-29 99.7 0.0 1.2 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 ubiquitin PF00240.21 MSTRG.5481.6_2 - 8.3e-07 28.5 0.0 1.4e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Pkinase PF00069.23 MSTRG.17506.1_1 - 5.6e-39 134.0 0.0 7.8e-39 133.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.17506.1_1 - 1.4e-22 80.1 0.0 2.1e-22 79.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.17506.1_1 - 0.014 14.6 0.0 0.02 14.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.12 MSTRG.17506.1_1 - 0.049 12.8 0.0 0.08 12.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Homeobox PF00046.27 MSTRG.17506.1_3 - 3e-21 74.9 7.0 5e-21 74.2 7.0 1.4 1 0 0 1 1 1 1 Homeobox domain QLQ PF08880.9 MSTRG.17506.1_3 - 0.0088 15.7 0.4 0.017 14.7 0.4 1.4 1 0 0 1 1 1 1 QLQ NOA36 PF06524.10 MSTRG.17506.1_3 - 0.082 12.1 1.8 0.13 11.5 1.8 1.2 1 0 0 1 1 1 0 NOA36 protein Radial_spoke PF04712.10 MSTRG.17506.1_3 - 0.086 11.6 2.3 0.12 11.1 2.3 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein DUF4746 PF15928.3 MSTRG.17506.1_3 - 1.9 7.7 6.0 2.6 7.2 6.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SH2 PF00017.22 MSTRG.5245.2_3 - 9.9e-10 38.2 0.0 1.9e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 SH2 domain NAPRTase PF04095.14 MSTRG.1770.1_1 - 0.00014 21.4 0.0 0.039 13.4 0.0 2.2 2 0 0 2 2 2 2 Nicotinate phosphoribosyltransferase (NAPRTase) family UQ_con PF00179.24 MSTRG.3750.1_2 - 1.2e-30 105.9 0.0 1.8e-30 105.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme DHR-2 PF06920.11 MSTRG.25293.2_1 - 3.3e-129 431.8 6.7 3.8e-129 431.6 6.7 1.0 1 0 0 1 1 1 1 Dock homology region 2 HAGH_C PF16123.3 MSTRG.14228.5_2 - 8.5e-28 96.6 0.3 1.5e-27 95.8 0.3 1.4 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.25 MSTRG.14228.5_2 - 2.4e-11 43.9 1.8 1.5e-06 28.3 0.7 2.2 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.5 MSTRG.14228.5_2 - 0.00081 18.8 0.2 0.0017 17.8 0.2 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain DEAD_2 PF06733.13 MSTRG.20516.1_2 - 2.4e-50 170.5 4.5 3.1e-50 170.1 4.5 1.1 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.13 MSTRG.20516.1_2 - 3.1e-08 33.7 0.0 0.00076 19.4 0.0 2.4 2 1 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.27 MSTRG.20516.1_2 - 1.8e-06 27.7 0.0 0.0006 19.5 0.0 2.1 1 1 1 2 2 2 2 DEAD/DEAH box helicase TCTP PF00838.15 MSTRG.14832.1_2 - 3.4e-61 206.2 3.6 4.1e-61 205.9 3.6 1.1 1 0 0 1 1 1 1 Translationally controlled tumour protein Spc7 PF08317.9 MSTRG.14832.1_2 - 0.045 12.5 0.0 0.058 12.1 0.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Peptidase_M3 PF01432.18 MSTRG.14832.1_2 - 0.058 12.5 0.0 0.076 12.1 0.0 1.1 1 0 0 1 1 1 0 Peptidase family M3 Phage_int_SAM_4 PF13495.4 MSTRG.14832.1_2 - 0.063 13.6 0.2 0.16 12.3 0.1 1.7 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain adh_short PF00106.23 MSTRG.12743.3_3 - 7.5e-53 178.8 0.0 1e-52 178.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 MSTRG.12743.3_3 - 1.1e-29 103.6 0.0 1.6e-29 103.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Bcl-2 PF00452.17 MSTRG.12743.3_3 - 4.9e-23 81.5 0.0 1.2e-22 80.3 0.0 1.6 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family KR PF08659.8 MSTRG.12743.3_3 - 4.5e-13 49.4 0.1 7.6e-13 48.6 0.1 1.3 1 0 0 1 1 1 1 KR domain Bcl-2_3 PF15286.4 MSTRG.12743.3_3 - 0.00055 20.5 0.0 0.0011 19.5 0.0 1.4 1 0 0 1 1 1 1 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like THF_DHG_CYH_C PF02882.17 MSTRG.12743.3_3 - 0.068 12.4 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_10 PF13460.4 MSTRG.12743.3_3 - 0.072 12.9 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding ADH_zinc_N PF00107.24 MSTRG.12743.3_3 - 0.1 12.3 0.1 0.2 11.4 0.1 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase G_glu_transpept PF01019.19 MSTRG.6558.2_2 - 2.9e-127 425.4 0.0 3.5e-127 425.2 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase DUF568 PF04526.11 MSTRG.16141.1_2 - 0.11 13.0 0.0 0.13 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF568) DUF3267 PF11667.6 MSTRG.2959.2_1 - 0.029 14.5 3.7 0.057 13.6 3.7 1.4 1 0 0 1 1 1 0 Putative zincin peptidase MEF2_binding PF09047.8 MSTRG.2959.2_2 - 4.2e-23 80.7 3.8 8e-23 79.9 3.8 1.5 1 0 0 1 1 1 1 MEF2 binding Pkinase_Tyr PF07714.15 MSTRG.16498.2_1 - 3.3e-93 311.6 0.0 2.8e-91 305.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.16498.2_1 - 2.9e-45 154.6 0.0 1e-44 152.8 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain SH2 PF00017.22 MSTRG.16498.2_1 - 2e-27 94.9 0.3 4e-27 93.9 0.3 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 MSTRG.16498.2_1 - 3.8e-19 67.9 0.3 2.2e-18 65.5 0.1 2.3 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 MSTRG.16498.2_1 - 3.6e-14 52.2 0.4 9.6e-14 50.8 0.1 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.16498.2_1 - 4.6e-09 35.7 0.0 1.1e-08 34.4 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain APH PF01636.21 MSTRG.16498.2_1 - 0.17 11.6 0.0 1 9.1 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family TMEM51 PF15345.4 MSTRG.3831.2_2 - 0.04 13.6 0.0 0.064 13.0 0.0 1.3 1 1 0 1 1 1 0 Transmembrane protein 51 DUF1191 PF06697.10 MSTRG.3831.2_2 - 0.063 12.4 0.0 0.091 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) OppC_N PF12911.5 MSTRG.3831.2_2 - 0.079 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C DUF1510 PF07423.9 MSTRG.3831.2_2 - 0.09 12.1 5.5 0.15 11.4 5.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1510) TMEM154 PF15102.4 MSTRG.3831.2_2 - 0.2 11.4 0.0 0.2 11.4 0.0 1.9 2 0 0 2 2 2 0 TMEM154 protein family Cwf_Cwc_15 PF04889.10 MSTRG.3831.2_2 - 0.24 11.0 21.8 0.3 10.6 21.8 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein BUD22 PF09073.8 MSTRG.3831.2_2 - 0.53 9.4 11.8 0.67 9.1 11.8 1.1 1 0 0 1 1 1 0 BUD22 RNA_pol_3_Rpc31 PF11705.6 MSTRG.3831.2_2 - 6.5 6.8 25.9 8.1 6.5 25.9 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 ADP_PFK_GK PF04587.13 MSTRG.28800.1_3 - 1.7e-26 92.7 0.0 1.8e-26 92.6 0.0 1.0 1 0 0 1 1 1 1 ADP-specific Phosphofructokinase/Glucokinase conserved region CD45 PF12567.6 MSTRG.14407.1_1 - 0.012 15.5 0.7 0.018 14.9 0.7 1.3 1 0 0 1 1 1 0 Leukocyte receptor CD45 DUF4745 PF15923.3 MSTRG.5431.1_3 - 1.8e-44 150.8 0.6 4e-44 149.7 0.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4745) CD36 PF01130.19 MSTRG.19646.10_1 - 7.8e-53 179.5 1.2 1e-51 175.8 1.2 2.0 1 1 0 1 1 1 1 CD36 family PARP PF00644.18 MSTRG.29285.1_1 - 4.6e-14 52.4 1.0 1.4e-13 50.9 1.0 1.7 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain V-set PF07686.15 MSTRG.15499.1_3 - 0.0003 20.8 0.0 0.00048 20.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 MSTRG.15499.1_3 - 0.034 14.6 0.0 0.07 13.6 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.15499.1_3 - 0.051 13.8 0.0 0.099 12.9 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain LRR_8 PF13855.4 MSTRG.7405.1_1 - 2.4e-38 129.6 71.5 3.9e-09 36.0 3.7 10.4 7 3 3 10 10 10 9 Leucine rich repeat LRR_4 PF12799.5 MSTRG.7405.1_1 - 4.2e-18 64.9 76.5 0.002 18.3 0.5 12.0 6 2 9 16 16 16 12 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 MSTRG.7405.1_1 - 6.7e-07 29.2 11.2 0.00039 20.2 0.2 4.0 3 1 0 4 4 4 2 Leucine rich repeats (6 copies) LRR_6 PF13516.4 MSTRG.7405.1_1 - 3.9e-06 26.3 56.8 0.037 14.0 0.2 16.5 18 0 0 18 18 18 2 Leucine Rich repeat LRR_1 PF00560.31 MSTRG.7405.1_1 - 0.00025 20.9 70.2 1.1 9.9 0.3 16.7 15 6 0 15 15 15 4 Leucine Rich Repeat LRR_9 PF14580.4 MSTRG.7405.1_1 - 0.077 12.4 27.9 0.19 11.1 0.5 5.9 1 1 4 6 6 6 0 Leucine-rich repeat HEAT_2 PF13646.4 MSTRG.13372.2_1 - 0.00024 21.3 0.0 0.0096 16.1 0.0 1.8 1 1 1 2 2 2 2 HEAT repeats SelP_N PF04592.12 MSTRG.13372.2_3 - 5.3 6.2 17.0 9.4 5.4 17.0 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Zip PF02535.20 MSTRG.13372.2_3 - 6.5 5.7 6.7 11 5.0 6.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DAG1 PF05454.9 MSTRG.6609.1_2 - 5.5e-131 436.1 7.4 8.6e-131 435.4 7.4 1.3 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) TMEM154 PF15102.4 MSTRG.6609.1_2 - 0.022 14.5 0.0 0.022 14.5 0.0 1.8 2 0 0 2 2 2 0 TMEM154 protein family DUF1191 PF06697.10 MSTRG.6609.1_2 - 0.11 11.5 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) Phage_holin_3_6 PF07332.9 MSTRG.6609.1_2 - 2.1 8.3 4.7 0.69 9.8 0.3 2.0 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Fibrinogen_C PF00147.16 MSTRG.10595.1_2 - 1e-56 192.1 0.3 1.6e-56 191.5 0.3 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fez1 PF06818.13 MSTRG.10595.1_2 - 0.0012 19.2 12.8 0.0025 18.2 12.8 1.4 1 0 0 1 1 1 1 Fez1 FliJ PF02050.14 MSTRG.10595.1_2 - 0.054 13.6 12.7 0.15 12.2 5.5 2.6 1 1 1 2 2 2 0 Flagellar FliJ protein LMBR1 PF04791.14 MSTRG.10595.1_2 - 0.056 12.2 1.6 0.072 11.8 1.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein V_ATPase_I PF01496.17 MSTRG.10595.1_2 - 0.076 10.8 5.3 0.11 10.3 5.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fib_alpha PF08702.8 MSTRG.10595.1_2 - 0.14 12.2 10.5 0.32 11.0 10.5 1.7 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF16 PF01519.14 MSTRG.10595.1_2 - 1.1 9.7 14.5 3.5 8.0 1.9 2.6 1 1 1 2 2 2 0 Protein of unknown function DUF16 NPV_P10 PF05531.10 MSTRG.10595.1_2 - 1.1 9.6 13.3 79 3.7 0.2 3.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Laminin_II PF06009.10 MSTRG.10595.1_2 - 1.3 8.9 9.1 8.8 6.2 7.7 2.5 1 1 1 2 2 2 0 Laminin Domain II APG6 PF04111.10 MSTRG.10595.1_2 - 7.3 5.8 12.1 0.94 8.7 6.4 1.9 1 1 1 2 2 2 0 Autophagy protein Apg6 Nup88 PF10168.7 MSTRG.10595.1_2 - 7.4 4.1 14.6 10 3.6 14.6 1.1 1 0 0 1 1 1 0 Nuclear pore component C8 PF08742.9 MSTRG.25034.1_2 - 6.8e-20 71.1 1.5 6.8e-20 71.1 1.5 2.4 1 1 1 2 2 2 1 C8 domain VWD PF00094.23 MSTRG.25034.1_2 - 3.2e-14 53.4 0.0 5.2e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type D domain ADIP PF11559.6 MSTRG.26205.5_3 - 0.004 17.1 10.9 0.004 17.1 10.9 2.7 3 0 0 3 3 3 1 Afadin- and alpha -actinin-Binding Mitofilin PF09731.7 MSTRG.26205.5_3 - 0.83 8.2 32.7 0.075 11.7 15.4 2.1 2 0 0 2 2 2 0 Mitochondrial inner membrane protein BUD22 PF09073.8 MSTRG.26205.5_3 - 1.3 8.1 54.8 0.031 13.5 43.1 2.3 2 0 0 2 2 2 0 BUD22 Cwf_Cwc_15 PF04889.10 MSTRG.26205.5_3 - 3 7.4 46.9 0.036 13.7 32.2 2.6 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein zf-TAZ PF02135.14 MSTRG.24116.4_2 - 6.7e-15 55.2 16.2 9.2e-15 54.7 16.2 1.2 1 0 0 1 1 1 1 TAZ zinc finger DEAD PF00270.27 MSTRG.20304.3_1 - 7.5e-33 113.6 0.0 1.5e-32 112.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.20304.3_1 - 2.1e-25 89.1 0.0 7.2e-25 87.4 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.20304.3_1 - 3.2e-06 27.1 0.0 9.6e-06 25.6 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.4 MSTRG.20304.3_1 - 0.095 12.3 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain CMS1 PF14617.4 MSTRG.20304.3_1 - 0.35 10.0 0.0 0.35 10.0 0.0 1.9 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit AMP-binding PF00501.26 MSTRG.16905.2_3 - 8.1e-23 80.5 0.0 1.1e-22 80.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme DUF3446 PF11928.6 MSTRG.3495.1_1 - 6.7 7.0 21.0 7.1 6.9 4.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3446) MAGI_u5 PF16666.3 MSTRG.20045.4_2 - 1e-41 142.0 10.5 2.5e-41 140.8 10.5 1.7 1 0 0 1 1 1 1 Unstructured region on MAGI PDZ PF00595.22 MSTRG.20045.4_2 - 5.3e-27 93.9 0.6 1.5e-09 37.9 0.1 3.4 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) WW PF00397.24 MSTRG.20045.4_2 - 1.2e-17 63.4 4.1 1.7e-09 37.3 0.2 2.7 2 0 0 2 2 2 2 WW domain MAGI_u1 PF16663.3 MSTRG.20045.4_2 - 1.6e-16 59.9 1.8 4.8e-16 58.3 1.8 1.9 1 0 0 1 1 1 1 Unstructured region on MAGI Guanylate_kin PF00625.19 MSTRG.20045.4_2 - 1.1e-10 41.4 0.0 2.1e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase PDZ_2 PF13180.4 MSTRG.20045.4_2 - 6e-08 32.8 0.0 0.023 14.9 0.0 2.9 3 0 0 3 3 3 2 PDZ domain Aminotran_1_2 PF00155.19 MSTRG.21472.1_3 - 5.5e-52 177.0 0.0 6.8e-52 176.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.18 MSTRG.21472.1_3 - 0.0036 15.7 0.0 0.0064 14.9 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.15 MSTRG.21472.1_3 - 0.03 13.5 0.0 0.061 12.5 0.0 1.4 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family GFA PF04828.12 MSTRG.22853.4_2 - 1.1e-09 38.3 1.4 1.1e-09 38.3 1.4 1.5 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme HGWP PF03578.13 MSTRG.2791.1_2 - 0.041 13.4 0.1 0.1 12.2 0.1 1.6 1 0 0 1 1 1 0 HGWP repeat CCDC85 PF10226.7 MSTRG.2791.1_3 - 3.3e-89 297.6 6.6 6.1e-89 296.7 6.6 1.4 1 0 0 1 1 1 1 CCDC85 family DUF4577 PF15145.4 MSTRG.2791.1_3 - 0.077 12.9 0.6 0.19 11.6 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4577) Shugoshin_N PF07558.9 MSTRG.2791.1_3 - 0.1 12.3 4.6 2.8 7.8 0.9 2.9 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region TSC22 PF01166.16 MSTRG.2791.1_3 - 0.83 9.9 10.5 7.7 6.8 0.3 3.4 3 0 0 3 3 3 0 TSC-22/dip/bun family ZapB PF06005.10 MSTRG.2791.1_3 - 4.2 7.8 11.9 0.89 9.9 0.7 3.3 3 0 0 3 3 3 0 Cell division protein ZapB LIM PF00412.20 MSTRG.23937.6_1 - 6.5e-31 106.2 32.4 8.6e-13 48.2 5.5 3.6 3 0 0 3 3 3 3 LIM domain Phospho_p8 PF10195.7 MSTRG.17933.5_1 - 0.96 9.8 5.2 2.4 8.6 5.2 1.6 1 0 0 1 1 1 0 DNA-binding nuclear phosphoprotein p8 MBT PF02820.16 MSTRG.17933.5_2 - 4.8e-25 87.6 0.3 8e-25 86.9 0.3 1.3 1 0 0 1 1 1 1 mbt repeat zf-C2HC PF01530.16 MSTRG.17933.5_2 - 4.1e-11 42.7 10.1 1.3e-10 41.1 10.1 2.0 1 0 0 1 1 1 1 Zinc finger, C2HC type MBT PF02820.16 MSTRG.17933.5_3 - 1e-56 189.0 0.4 4.2e-30 103.8 0.1 2.3 2 0 0 2 2 2 2 mbt repeat SAM_1 PF00536.28 MSTRG.17933.5_3 - 1.2e-13 51.1 0.0 1.8e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 MSTRG.17933.5_3 - 7e-05 22.7 0.0 0.00011 22.1 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 MSTRG.17933.5_3 - 0.042 13.7 0.0 0.081 12.8 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Presenilin PF01080.15 MSTRG.17933.5_3 - 1.9 7.0 4.6 2.8 6.5 4.6 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.12 MSTRG.17933.5_3 - 6.4 4.8 9.0 9 4.3 9.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Plectin PF00681.18 MSTRG.7674.1_1 - 4.2e-60 199.2 0.0 2.9e-13 49.3 0.0 11.5 11 2 1 12 12 12 8 Plectin repeat Spectrin PF00435.19 MSTRG.7674.1_1 - 2.4e-08 34.3 28.1 1.1e-05 25.7 5.3 19.3 13 5 3 18 18 18 5 Spectrin repeat ERM PF00769.17 MSTRG.7674.1_1 - 0.00094 18.9 32.7 0.00094 18.9 32.7 13.3 6 2 5 12 12 12 1 Ezrin/radixin/moesin family Imm59 PF15597.4 MSTRG.7674.1_1 - 0.079 13.1 2.9 0.53 10.4 2.9 2.5 1 0 0 1 1 1 0 Immunity protein 59 Tetraspannin PF00335.18 MSTRG.17584.1_3 - 3.1e-51 174.0 9.8 3.1e-51 174.0 9.8 1.8 2 0 0 2 2 2 1 Tetraspanin family DUF4199 PF13858.4 MSTRG.17584.1_3 - 4.5e-05 23.8 1.3 4.5e-05 23.8 1.3 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF4199) DUF996 PF06195.11 MSTRG.17584.1_3 - 0.15 12.2 6.3 0.071 13.3 3.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF996) DUF1218 PF06749.10 MSTRG.17584.1_3 - 0.25 11.7 9.0 1.1 9.6 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1218) DUF308 PF03729.11 MSTRG.17584.1_3 - 0.26 11.5 18.5 0.35 11.1 6.6 2.6 1 1 1 2 2 2 0 Short repeat of unknown function (DUF308) DUF373 PF04123.11 MSTRG.17584.1_3 - 0.34 10.2 3.5 0.55 9.5 3.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF373) 7tm_1 PF00001.19 MSTRG.20535.1_2 - 1.4e-35 122.7 20.7 7.3e-35 120.4 20.7 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TMEM72 PF16054.3 MSTRG.20535.1_2 - 0.79 9.3 7.4 0.13 11.8 1.0 2.5 3 1 0 3 3 3 0 Transmembrane protein family 72 PufQ PF05398.9 MSTRG.20535.1_2 - 1.6 8.8 6.3 4 7.5 0.1 3.7 2 2 2 4 4 4 0 PufQ cytochrome subunit Telethonin PF09470.8 MSTRG.2436.1_2 - 1.9e-74 248.9 0.4 2.9e-74 248.3 0.5 1.3 1 0 0 1 1 1 1 Telethonin protein UCH PF00443.27 MSTRG.26022.1_3 - 7.9e-23 81.1 0.1 1.4e-22 80.3 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ion_trans PF00520.29 MSTRG.18720.1_1 - 3.5e-39 134.4 4.7 2.4e-30 105.4 0.5 2.1 2 0 0 2 2 2 2 Ion transport protein PKD_channel PF08016.10 MSTRG.18720.1_1 - 0.3 9.6 4.1 2.6 6.5 0.4 2.2 2 0 0 2 2 2 0 Polycystin cation channel Glycos_transf_4 PF00953.19 MSTRG.9376.1_2 - 1e-32 113.1 20.8 1.2e-32 113.0 16.9 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 4 DUF4133 PF13571.4 MSTRG.9376.1_2 - 5.2 7.3 6.6 0.87 9.8 1.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4133) Dimer_Tnp_hAT PF05699.12 MSTRG.251.1_1 - 8.6e-16 57.4 0.0 1.5e-15 56.6 0.0 1.3 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region AMP-binding PF00501.26 MSTRG.20195.1_3 - 2.5e-95 319.4 0.0 3.4e-95 319.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 MSTRG.20195.1_3 - 2e-23 83.0 0.4 3.6e-23 82.2 0.4 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.3 MSTRG.20195.1_3 - 1.3e-16 60.1 0.6 3e-16 58.9 0.6 1.7 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus zf-CCCH PF00642.22 MSTRG.14940.4_2 - 1.7e-11 43.6 19.9 8.6e-05 22.2 0.7 4.7 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.3 MSTRG.14940.4_2 - 1.1e-05 25.5 9.1 0.024 14.8 0.8 2.7 2 0 0 2 2 2 2 Zinc-finger containing family zf-CCCH_2 PF14608.4 MSTRG.14940.4_2 - 1.5e-05 25.1 24.5 0.29 11.6 0.8 4.9 4 0 0 4 4 4 4 RNA-binding, Nab2-type zinc finger Torus PF16131.3 MSTRG.14940.4_2 - 0.058 14.0 18.8 0.2 12.3 0.2 4.4 2 2 2 4 4 4 0 Torus domain DUF1936 PF09151.8 MSTRG.14940.4_2 - 1 9.2 5.0 8.3 6.3 0.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1936) MFS_1 PF07690.14 MSTRG.15777.1_1 - 0.13 11.1 12.7 0.005 15.7 7.1 1.5 2 0 0 2 2 2 0 Major Facilitator Superfamily GYF PF02213.14 MSTRG.6644.3_1 - 8.9e-20 70.0 0.1 1.8e-19 69.1 0.1 1.6 1 0 0 1 1 1 1 GYF domain DUF4339 PF14237.4 MSTRG.6644.3_1 - 0.005 16.5 2.6 0.006 16.2 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4339) DUF4574 PF15141.4 MSTRG.6644.3_1 - 0.17 11.7 5.9 0.91 9.3 5.9 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4574) U79_P34 PF03064.14 MSTRG.6644.3_1 - 0.41 9.8 7.1 0.95 8.6 7.1 1.6 1 0 0 1 1 1 0 HSV U79 / HCMV P34 DUF4192 PF13830.4 MSTRG.6644.3_1 - 0.62 9.9 4.2 4.5 7.1 2.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4192) Mito_carr PF00153.25 MSTRG.26196.1_1 - 3.9e-44 148.4 0.6 1.5e-24 85.6 0.0 2.2 2 0 0 2 2 2 2 Mitochondrial carrier protein Auxin_repressed PF05564.10 MSTRG.29237.1_2 - 0.02 15.4 1.0 0.04 14.5 0.8 1.6 1 1 0 1 1 1 0 Dormancy/auxin associated protein Bromo_MP PF01573.14 MSTRG.29237.1_2 - 0.14 11.3 0.0 0.2 10.8 0.0 1.1 1 0 0 1 1 1 0 Bromovirus movement protein SH3_2 PF07653.15 MSTRG.27241.1_1 - 9.7e-22 76.3 0.1 5.3e-10 38.7 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.26 MSTRG.27241.1_1 - 6.2e-20 70.4 0.3 2.3e-15 55.8 0.1 2.3 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.4 MSTRG.27241.1_1 - 5.7e-15 54.8 0.1 4.3e-10 39.1 0.1 2.4 2 0 0 2 2 2 2 Variant SH3 domain 7tm_2 PF00002.22 MSTRG.17532.1_3 - 5.2e-22 78.2 15.3 7.9e-22 77.6 15.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.19 MSTRG.17532.1_3 - 2.1e-13 50.5 4.8 6.3e-13 49.0 4.8 1.8 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif SpoIIM PF01944.15 MSTRG.17532.1_3 - 4.2 7.3 11.5 2.2 8.1 0.0 3.0 2 1 1 3 3 3 0 Stage II sporulation protein M zf-MYND PF01753.16 MSTRG.26966.1_3 - 3.7e-08 33.2 23.9 3.7e-08 33.2 23.9 1.6 2 0 0 2 2 2 1 MYND finger Kelch_1 PF01344.23 MSTRG.14775.1_2 - 8.5e-21 73.1 16.9 2.9e-10 39.4 0.3 3.4 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.4 MSTRG.14775.1_2 - 6.2e-09 35.8 0.3 7.1e-08 32.4 0.1 3.1 4 1 0 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.4 MSTRG.14775.1_2 - 3.5e-08 33.3 3.8 0.00067 19.7 0.1 3.5 2 1 1 3 3 3 2 Kelch motif Kelch_2 PF07646.13 MSTRG.14775.1_2 - 1.1e-07 31.4 0.8 0.09 12.7 0.0 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.4 MSTRG.14775.1_2 - 3.8e-06 26.6 0.1 0.21 11.5 0.4 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.4 MSTRG.14775.1_2 - 0.0006 19.6 5.2 0.021 14.7 0.1 2.9 4 0 0 4 4 4 2 Galactose oxidase, central domain PQQ_3 PF13570.4 MSTRG.14775.1_2 - 0.16 12.4 1.8 8.2 6.9 0.2 2.7 3 0 0 3 3 3 0 PQQ-like domain P2X_receptor PF00864.17 MSTRG.22855.1_2 - 6.8e-156 518.8 1.7 8.8e-156 518.4 1.7 1.1 1 0 0 1 1 1 1 ATP P2X receptor Peptidase_M13 PF01431.19 MSTRG.10019.1_2 - 6.3e-32 110.7 0.8 1.2e-31 109.8 0.0 1.7 2 0 0 2 2 2 1 Peptidase family M13 Peptidase_M13_N PF05649.11 MSTRG.10019.1_2 - 6.2e-13 49.1 0.5 6.2e-13 49.1 0.5 1.5 2 0 0 2 2 2 1 Peptidase family M13 Pellino PF04710.12 MSTRG.2061.1_1 - 4.4e-194 644.7 0.0 5.7e-194 644.3 0.0 1.1 1 0 0 1 1 1 1 Pellino IncA PF04156.12 MSTRG.15441.2_2 - 0.0034 17.1 6.9 0.0034 17.1 6.9 3.7 3 1 0 3 3 3 2 IncA protein Fez1 PF06818.13 MSTRG.15441.2_2 - 0.15 12.4 18.0 0.24 11.7 0.4 3.2 3 0 0 3 3 3 0 Fez1 APG6 PF04111.10 MSTRG.15441.2_2 - 0.78 8.9 20.3 1.2 8.4 4.5 3.1 3 0 0 3 3 3 0 Autophagy protein Apg6 Spc7 PF08317.9 MSTRG.15441.2_2 - 3.6 6.2 30.1 2.9 6.6 1.3 3.3 3 0 0 3 3 3 0 Spc7 kinetochore protein RasGAP_C PF03836.13 MSTRG.15441.2_2 - 4.1 7.4 21.4 3.9 7.5 2.8 3.9 4 0 0 4 4 4 0 RasGAP C-terminus DUF16 PF01519.14 MSTRG.15441.2_2 - 5.1 7.5 29.1 0.47 10.8 1.1 3.7 4 0 0 4 4 4 0 Protein of unknown function DUF16 DUF4407 PF14362.4 MSTRG.15441.2_2 - 6.5 5.9 21.4 13 4.9 0.6 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) DUF3584 PF12128.6 MSTRG.15441.2_2 - 7.1 3.9 17.3 0.15 9.5 3.7 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3584) Baculo_PEP_C PF04513.10 MSTRG.15441.2_2 - 7.7 6.4 12.5 0.19 11.6 3.2 2.7 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus PilO PF04350.11 MSTRG.15441.2_2 - 9.2 6.3 9.6 1.5 8.8 3.5 2.5 2 1 0 2 2 2 0 Pilus assembly protein, PilO Serine_rich PF08824.8 MSTRG.15441.2_3 - 0.048 13.5 0.4 0.083 12.8 0.4 1.3 1 0 0 1 1 1 0 Serine rich protein interaction domain IncA PF04156.12 MSTRG.15441.2_3 - 0.11 12.2 5.6 0.17 11.5 5.6 1.2 1 0 0 1 1 1 0 IncA protein HAUS-augmin3 PF14932.4 MSTRG.15441.2_3 - 0.29 10.5 3.4 0.43 9.9 3.4 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF4407 PF14362.4 MSTRG.15441.2_3 - 0.3 10.3 3.1 0.5 9.5 3.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) APG6 PF04111.10 MSTRG.15441.2_3 - 1 8.5 3.3 1.5 8.0 3.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Macoilin PF09726.7 MSTRG.15441.2_3 - 1.1 7.6 4.1 1.6 7.1 4.1 1.1 1 0 0 1 1 1 0 Transmembrane protein Jnk-SapK_ap_N PF09744.7 MSTRG.15441.2_3 - 2.7 8.0 7.9 4.6 7.3 7.9 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 ZapB PF06005.10 MSTRG.15441.2_3 - 2.8 8.3 6.2 1.8 8.9 3.3 1.6 1 1 1 2 2 2 0 Cell division protein ZapB EXS PF03124.12 MSTRG.8446.1_2 - 1.3e-103 346.7 22.8 1.3e-103 346.7 22.8 1.8 2 0 0 2 2 2 1 EXS family SPX PF03105.17 MSTRG.8446.1_2 - 5e-19 69.4 22.1 1.5e-13 51.4 5.1 2.4 2 1 1 3 3 3 2 SPX domain STIL_N PF15253.4 MSTRG.24355.2_1 - 8e-139 463.0 0.0 1.1e-138 462.5 0.0 1.2 1 0 0 1 1 1 1 SCL-interrupting locus protein N-terminus TGFb_propeptide PF00688.16 MSTRG.27125.3_2 - 1.7e-43 149.0 0.9 2.7e-43 148.4 0.9 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 MSTRG.27125.3_2 - 3.2e-24 85.7 3.5 7.6e-24 84.5 3.5 1.7 1 0 0 1 1 1 1 Transforming growth factor beta like domain Topoisom_I PF01028.18 MSTRG.22222.1_1 - 7.4e-99 329.5 2.5 7.4e-99 329.5 2.5 1.7 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.13 MSTRG.22222.1_1 - 6e-96 319.9 2.6 6e-96 319.9 2.6 3.0 3 1 1 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.4 MSTRG.22222.1_1 - 3.5e-34 116.4 0.2 1.1e-33 114.9 0.2 1.9 1 0 0 1 1 1 1 C-terminal topoisomerase domain VPS13_mid_rpt PF16910.3 MSTRG.12246.2_1 - 5.2e-75 251.8 16.4 1.1e-65 221.3 1.2 5.3 4 1 0 4 4 4 2 Repeating coiled region of VPS13 VPS13 PF16908.3 MSTRG.12246.2_1 - 7e-73 245.2 7.3 6e-69 232.3 0.2 4.5 5 0 0 5 5 5 3 Vacuolar sorting-associated protein 13, N-terminal VPS13_C PF16909.3 MSTRG.12246.2_1 - 1.7e-65 219.9 3.6 2.3e-61 206.5 0.1 2.9 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.5 MSTRG.12246.2_1 - 4e-39 133.2 0.2 2e-38 131.0 0.2 2.4 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 SHR-BD PF06650.10 MSTRG.12246.2_1 - 4.8e-38 131.0 0.1 6.5e-34 117.4 0.0 3.0 3 0 0 3 3 3 2 SHR-binding domain of vacuolar-sorting associated protein 13 ATG_C PF09333.9 MSTRG.12246.2_1 - 2.3e-14 53.4 0.4 1.2e-13 51.0 0.0 2.5 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain DUF3482 PF11981.6 MSTRG.12246.2_1 - 0.31 10.3 1.8 0.74 9.0 1.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) CAP_N PF01213.17 MSTRG.21822.1_1 - 1.9 7.7 3.5 2.2 7.6 3.5 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Acyltransf_C PF16076.3 MSTRG.25578.2_2 - 6.3e-16 58.2 0.0 1.6e-15 56.9 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase C-terminus zf-H2C2_2 PF13465.4 MSTRG.12412.2_1 - 2e-68 223.8 112.5 2.3e-10 40.3 0.6 16.4 16 0 0 16 16 16 13 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.12412.2_1 - 1.2e-58 192.3 115.7 1.6e-06 28.1 0.6 16.3 16 0 0 16 16 16 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.12412.2_1 - 6e-51 166.5 116.5 0.00014 22.3 0.2 16.3 16 0 0 16 16 16 14 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.12412.2_1 - 7.3e-31 105.7 92.7 0.00015 21.8 1.5 16.2 16 0 0 16 16 16 11 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.12412.2_1 - 4.8e-24 83.9 102.8 0.0063 16.7 0.7 15.7 16 0 0 16 16 15 10 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 MSTRG.12412.2_1 - 1.8e-22 78.6 104.6 0.003 17.3 0.5 16.9 16 1 0 16 16 16 9 C2H2-type zinc finger zf-C2H2_11 PF16622.3 MSTRG.12412.2_1 - 2.8e-16 58.8 68.7 0.005 16.4 0.1 14.1 15 0 0 15 15 15 7 zinc-finger C2H2-type zf-Di19 PF05605.10 MSTRG.12412.2_1 - 4.2e-06 26.8 73.8 0.0018 18.4 1.9 9.3 5 3 3 9 9 9 4 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.4 MSTRG.12412.2_1 - 3.3e-05 23.4 4.5 0.0008 19.0 1.1 13.0 13 2 0 13 13 12 2 C2H2-type zinc-finger domain zf-C2H2_8 PF15909.3 MSTRG.12412.2_1 - 4.7e-05 23.5 63.2 0.00014 21.9 1.6 8.3 1 1 6 8 8 8 5 C2H2-type zinc ribbon Trm112p PF03966.14 MSTRG.12412.2_1 - 0.0016 18.9 9.9 0.5 10.8 0.1 5.3 5 2 1 6 6 6 1 Trm112p-like protein BolA PF01722.16 MSTRG.12412.2_1 - 0.015 15.5 24.7 1.4 9.1 0.2 7.4 4 3 2 6 6 6 0 BolA-like protein DUF3268 PF11672.6 MSTRG.12412.2_1 - 0.021 15.0 0.9 0.021 15.0 0.9 6.8 5 2 4 9 9 9 0 zinc-finger-containing domain zf-C2H2_2 PF12756.5 MSTRG.12412.2_1 - 0.15 12.3 87.3 2.1 8.6 0.1 12.9 1 1 11 13 13 13 0 C2H2 type zinc-finger (2 copies) GAGA PF09237.9 MSTRG.12412.2_1 - 0.18 11.5 20.1 0.57 9.9 0.3 6.3 4 2 4 8 8 8 0 GAGA factor zf-CHCC PF10276.7 MSTRG.12412.2_1 - 0.46 10.5 24.6 1.1 9.2 0.3 7.3 7 0 0 7 7 7 0 Zinc-finger domain zinc_ribbon_9 PF14369.4 MSTRG.12412.2_1 - 0.76 10.0 39.6 4.1 7.6 0.1 10.4 12 1 1 13 13 11 0 zinc-ribbon DUF3797 PF12677.5 MSTRG.12412.2_1 - 1.3 8.8 7.0 13 5.7 0.7 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF3797) CAF1A PF12253.6 MSTRG.12412.2_1 - 1.6 8.8 8.1 3.9 7.6 8.1 1.6 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A FerB PF08150.10 MSTRG.12412.2_1 - 1.6 9.2 3.9 1.9 9.0 0.5 2.9 2 1 1 3 3 2 0 FerB (NUC096) domain zf-ribbon_3 PF13248.4 MSTRG.12412.2_1 - 4.6 6.7 26.3 0.39 10.1 0.1 7.2 8 0 0 8 8 7 0 zinc-ribbon domain zinc_ribbon_15 PF17032.3 MSTRG.12412.2_1 - 4.6 7.9 70.0 1.4 9.6 2.2 8.3 2 1 6 8 8 7 0 zinc-ribbon family RRM_1 PF00076.20 MSTRG.17635.3_1 - 7.2e-30 102.5 0.0 5.2e-17 61.3 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 MSTRG.17635.3_1 - 0.0031 17.3 0.0 0.041 13.7 0.0 2.2 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.3 MSTRG.17635.3_1 - 0.0058 16.6 0.0 0.02 14.9 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif RRM_3 PF08777.9 MSTRG.17635.3_1 - 0.013 15.4 0.0 1.8 8.5 0.0 2.2 2 0 0 2 2 2 0 RNA binding motif RRM_occluded PF16842.3 MSTRG.17635.3_1 - 0.09 12.5 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif DUF2457 PF10446.7 MSTRG.17635.3_1 - 1.2 8.1 10.2 1.6 7.7 10.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Mcl1_mid PF12341.6 MSTRG.5899.1_1 - 9.1e-100 333.6 0.0 4.8e-99 331.2 0.0 2.1 2 0 0 2 2 2 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.30 MSTRG.5899.1_1 - 6.9e-20 70.9 11.9 1e-07 32.4 0.1 6.6 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.5899.1_1 - 1.7e-11 44.1 0.4 7.8e-05 22.8 0.0 4.9 1 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain HMG_box PF00505.17 MSTRG.5899.1_1 - 8.3e-08 32.4 0.0 1.8e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box eIF2A PF08662.9 MSTRG.5899.1_1 - 2.3e-06 27.5 0.1 3.8e-05 23.5 0.0 2.7 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.3 MSTRG.5899.1_1 - 0.026 13.3 0.5 0.65 8.8 0.1 2.6 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein SET PF00856.26 MSTRG.7278.1_1 - 6.9e-11 42.7 0.1 4e-10 40.2 0.1 2.1 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.16 MSTRG.7278.1_1 - 0.00046 20.1 9.8 0.00046 20.1 9.8 3.5 4 1 0 4 4 4 1 MYND finger zf-HIT PF04438.14 MSTRG.7278.1_1 - 0.024 14.4 1.2 0.024 14.4 1.2 2.2 2 0 0 2 2 2 0 HIT zinc finger DUF3844 PF12955.5 MSTRG.7278.1_1 - 0.71 9.9 7.6 12 6.0 3.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3844) DUF3585 PF12130.6 MSTRG.20669.2_2 - 5.5e-38 130.0 22.4 5.5e-38 130.0 22.4 6.7 4 2 2 6 6 6 1 Protein of unknown function (DUF3585) CH PF00307.29 MSTRG.20669.2_2 - 5.2e-21 74.7 0.0 9.5e-21 73.9 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 MSTRG.20669.2_2 - 1.9e-06 27.5 0.0 3.3e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 CAMSAP CH domain CH_2 PF06294.9 MSTRG.20669.2_2 - 0.023 14.7 0.0 0.043 13.8 0.0 1.4 1 0 0 1 1 1 0 CH-like domain in sperm protein Serpin PF00079.18 MSTRG.7558.1_2 - 1.7e-109 366.4 3.0 2.1e-109 366.1 3.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SH3_9 PF14604.4 MSTRG.29195.1_2 - 0.049 13.4 0.0 0.079 12.7 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain LRR_4 PF12799.5 MSTRG.5195.2_2 - 1e-17 63.7 17.7 4.6e-06 26.7 0.5 4.3 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 MSTRG.5195.2_2 - 2.5e-13 49.8 3.4 9.9e-06 25.0 0.0 2.9 2 1 0 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.4 MSTRG.5195.2_2 - 3.1e-11 42.7 18.4 4.1e-05 23.1 4.4 4.0 2 1 1 3 3 3 3 Leucine rich repeat LRR_1 PF00560.31 MSTRG.5195.2_2 - 4.7e-05 23.1 16.5 1.4 9.6 0.2 6.6 6 1 0 6 6 6 3 Leucine Rich Repeat LRR_6 PF13516.4 MSTRG.5195.2_2 - 0.0098 15.7 19.7 0.6 10.2 0.4 5.5 6 0 0 6 6 6 3 Leucine Rich repeat DUF4379 PF14311.4 MSTRG.743.1_1 - 0.13 12.5 3.7 11 6.3 0.1 2.6 2 0 0 2 2 2 0 Probable Zinc-ribbon domain SMP_LBD PF17047.3 MSTRG.743.1_2 - 7.1e-60 201.4 0.1 2.8e-59 199.5 0.2 1.9 3 0 0 3 3 3 1 Synaptotagmin-like mitochondrial-lipid-binding domain C2 PF00168.28 MSTRG.743.1_2 - 5e-51 171.2 1.0 3.2e-23 81.8 0.0 3.4 3 0 0 3 3 3 3 C2 domain NT-C2 PF10358.7 MSTRG.743.1_2 - 0.0013 18.4 0.0 0.071 12.7 0.1 2.7 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins CEP76-C2 PF15627.4 MSTRG.743.1_2 - 0.087 12.3 0.3 1.6 8.1 0.0 2.3 2 0 0 2 2 2 0 CEP76 C2 domain Sushi PF00084.18 MSTRG.19617.1_2 - 5.5e-42 142.1 22.5 8e-11 42.3 0.2 5.5 5 0 0 5 5 5 5 Sushi repeat (SCR repeat) CUB PF00431.18 MSTRG.19617.1_2 - 1.1e-23 83.6 0.0 1.1e-13 51.4 0.0 3.6 3 1 0 3 3 3 3 CUB domain Band_3_cyto PF07565.11 MSTRG.17125.3_1 - 9.8e-14 51.7 0.0 1.8e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 Band 3 cytoplasmic domain Band_3_cyto PF07565.11 MSTRG.17125.3_2 - 4e-59 200.5 0.4 4e-59 200.5 0.4 1.5 2 0 0 2 2 2 1 Band 3 cytoplasmic domain zf-C2H2 PF00096.24 MSTRG.11044.1_2 - 9.9e-12 44.5 22.9 0.00028 21.0 0.4 4.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.11044.1_2 - 1.3e-08 34.7 10.1 1e-05 25.6 1.6 5.0 4 0 0 4 4 4 2 Zinc-finger double domain ABC_membrane PF00664.21 MSTRG.16369.1_1 - 3.7e-38 131.6 15.0 3.7e-38 131.6 15.0 2.0 3 0 0 3 3 3 1 ABC transporter transmembrane region COA2 PF17051.3 MSTRG.16369.1_1 - 0.066 13.2 0.1 0.066 13.2 0.1 2.5 3 0 0 3 3 3 0 Cytochrome C oxidase assembly factor 2 FAD_binding_7 PF03441.12 MSTRG.18470.1_3 - 9e-37 126.3 0.3 1.4e-36 125.7 0.3 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase TPR_2 PF07719.15 MSTRG.17569.2_3 - 4e-16 57.6 0.6 3.2e-05 23.6 0.0 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.17569.2_3 - 1.4e-14 53.1 0.6 3e-05 23.5 0.1 5.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.17569.2_3 - 5.7e-12 44.6 1.4 0.11 12.4 0.0 7.1 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.17569.2_3 - 1.8e-10 40.6 2.6 0.54 11.1 0.0 7.2 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.17569.2_3 - 6.8e-10 39.0 8.4 0.045 13.9 0.0 6.3 6 2 1 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.17569.2_3 - 2.7e-09 36.4 0.4 0.0094 16.0 0.0 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.17569.2_3 - 1.5e-07 30.8 1.2 0.074 12.6 0.2 4.8 3 1 1 4 4 4 3 TPR repeat TPR_16 PF13432.4 MSTRG.17569.2_3 - 1.9e-06 28.3 0.2 1.2 9.8 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.17569.2_3 - 0.00018 21.1 12.2 2.1 8.2 0.2 6.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.4 MSTRG.17569.2_3 - 0.00065 19.7 4.3 0.021 14.8 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.17569.2_3 - 0.0012 19.2 0.3 1.8 9.0 0.0 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat ChAPs PF09295.8 MSTRG.17569.2_3 - 0.0056 15.6 1.3 0.018 13.9 0.2 2.2 2 1 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) ANAPC3 PF12895.5 MSTRG.17569.2_3 - 0.08 13.0 1.4 0.52 10.4 0.0 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.4 MSTRG.17569.2_3 - 0.087 12.8 0.4 14 5.7 0.0 2.6 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.17569.2_3 - 0.34 11.5 2.3 2.6e+02 2.4 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat wnt PF00110.17 MSTRG.24192.2_2 - 7.3e-11 42.0 0.0 1e-10 41.6 0.0 1.1 1 0 0 1 1 1 1 wnt family wnt PF00110.17 MSTRG.24192.2_3 - 7.8e-53 179.8 19.0 1.1e-52 179.3 19.0 1.2 1 0 0 1 1 1 1 wnt family Methyltransf_23 PF13489.4 MSTRG.24587.2_2 - 3.8e-17 62.5 0.0 5.7e-17 62.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 MSTRG.24587.2_2 - 3.2e-16 59.6 0.1 6.7e-16 58.6 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 MSTRG.24587.2_2 - 2.8e-11 43.9 0.1 6e-11 42.8 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 MSTRG.24587.2_2 - 3.1e-10 40.5 0.0 6.1e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 MSTRG.24587.2_2 - 1.3e-07 31.4 0.0 2.2e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.18 MSTRG.24587.2_2 - 0.00041 19.6 0.0 0.00091 18.5 0.0 1.5 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase NodS PF05401.9 MSTRG.24587.2_2 - 0.055 13.0 0.0 0.13 11.7 0.0 1.6 1 1 0 1 1 1 0 Nodulation protein S (NodS) DUF4810 PF16068.3 MSTRG.16952.1_3 - 0.14 12.6 0.0 0.28 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4810) RRM_1 PF00076.20 MSTRG.8996.2_3 - 5.2e-61 202.3 0.0 9.6e-21 73.3 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 MSTRG.8996.2_3 - 2.7e-14 52.7 0.0 4.5e-05 22.9 0.0 3.1 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.10 MSTRG.8996.2_3 - 5.2e-05 23.2 0.0 0.41 10.7 0.0 2.9 3 0 0 3 3 3 2 BRCA1-associated protein 2 RRM_3 PF08777.9 MSTRG.8996.2_3 - 0.0042 17.0 0.0 0.47 10.4 0.0 2.6 2 0 0 2 2 2 1 RNA binding motif RRM_occluded PF16842.3 MSTRG.8996.2_3 - 0.0042 16.8 0.0 10 5.9 0.0 3.2 3 0 0 3 3 3 2 Occluded RNA-recognition motif RNA_bind PF08675.9 MSTRG.8996.2_3 - 0.03 14.2 0.0 1.7 8.6 0.0 3.2 3 1 0 3 3 3 0 RNA binding domain DEAD PF00270.27 MSTRG.18305.1_2 - 6e-43 146.5 0.0 1.3e-42 145.4 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.18305.1_2 - 6.4e-28 97.2 0.0 3.7e-27 94.8 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain KH_1 PF00013.27 MSTRG.18305.1_2 - 1.2e-12 47.3 2.2 2.6e-12 46.2 2.2 1.6 1 0 0 1 1 1 1 KH domain MOEP19 PF16005.3 MSTRG.18305.1_2 - 2.6e-08 33.7 0.0 9.1e-08 31.9 0.0 1.8 2 0 0 2 2 2 1 KH-like RNA-binding domain ResIII PF04851.13 MSTRG.18305.1_2 - 9.3e-06 25.6 0.0 4e-05 23.5 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit KH_2 PF07650.15 MSTRG.18305.1_2 - 0.0013 18.3 0.6 0.0035 17.0 0.6 1.7 1 0 0 1 1 1 1 KH domain CMS1 PF14617.4 MSTRG.18305.1_2 - 0.0056 15.9 0.0 0.01 15.0 0.0 1.3 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit PBP1_TM PF14812.4 MSTRG.17878.2_3 - 0.48 10.8 8.4 1.3 9.4 8.4 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal AMP-binding PF00501.26 MSTRG.27212.3_2 - 2.4e-100 336.0 0.0 3.1e-100 335.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 MSTRG.27212.3_2 - 7.3e-07 30.0 0.1 1.9e-06 28.6 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Mak10 PF04112.11 MSTRG.27212.3_2 - 0.0025 17.2 0.0 0.0055 16.1 0.0 1.5 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase PLDc_3 PF13918.4 MSTRG.27212.3_2 - 0.11 12.0 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 PLD-like domain Prominin PF05478.9 MSTRG.27532.1_1 - 6.2e-193 642.8 4.3 7.1e-193 642.6 4.3 1.0 1 0 0 1 1 1 1 Prominin Tweety PF04906.11 MSTRG.27532.1_1 - 0.00044 18.9 0.7 0.0017 17.0 0.0 2.1 2 0 0 2 2 2 1 Tweety COG5 PF10392.7 MSTRG.27532.1_1 - 0.0063 16.6 8.0 1.3 9.0 0.1 4.0 4 0 0 4 4 4 1 Golgi transport complex subunit 5 DUF1664 PF07889.10 MSTRG.27532.1_1 - 0.0081 16.0 3.8 11 6.0 0.0 4.5 4 1 1 5 5 5 1 Protein of unknown function (DUF1664) DUF5082 PF16888.3 MSTRG.27532.1_1 - 0.011 15.9 2.6 10 6.3 0.0 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF5082) Reo_sigmaC PF04582.10 MSTRG.27532.1_1 - 0.065 12.5 4.4 2.8 7.1 0.4 2.5 2 0 0 2 2 2 0 Reovirus sigma C capsid protein BLOC1_2 PF10046.7 MSTRG.27532.1_1 - 0.26 11.5 8.1 8.5 6.6 0.0 4.3 6 0 0 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AIP3 PF03915.11 MSTRG.27532.1_1 - 0.34 9.8 1.8 8.3 5.2 0.2 2.2 2 0 0 2 2 2 0 Actin interacting protein 3 IFT57 PF10498.7 MSTRG.27532.1_1 - 0.39 9.5 3.5 0.43 9.4 0.3 2.4 3 0 0 3 3 3 0 Intra-flagellar transport protein 57 DUF1218 PF06749.10 MSTRG.27532.1_1 - 0.66 10.4 3.4 0.99 9.8 2.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) TPR_1 PF00515.26 MSTRG.17569.3_3 - 7.7e-07 28.5 0.4 1.5e-05 24.5 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.17569.3_3 - 3.2e-06 26.7 3.3 1.6e-05 24.5 0.0 3.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.17569.3_3 - 6.2e-05 23.5 0.2 0.58 10.8 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.17569.3_3 - 8e-05 23.0 0.0 1.5 9.7 0.0 4.6 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.17569.3_3 - 0.00021 21.1 0.1 0.0047 16.9 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.17569.3_3 - 0.00056 19.6 0.7 1.1 9.3 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.17569.3_3 - 0.00078 19.1 3.9 1 9.2 0.2 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.17569.3_3 - 0.00094 18.7 0.9 0.037 13.6 0.2 3.1 2 1 1 3 3 3 2 TPR repeat TPR_12 PF13424.4 MSTRG.17569.3_3 - 0.0036 17.4 3.9 0.31 11.2 1.7 4.3 4 1 0 4 4 4 1 Tetratricopeptide repeat PDZ PF00595.22 MSTRG.24883.4_1 - 3.9e-12 46.2 2.9 7.8e-12 45.3 2.9 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) SAM_2 PF07647.15 MSTRG.24883.4_1 - 2.7e-11 43.3 0.1 5.1e-11 42.4 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 MSTRG.24883.4_1 - 1.3e-09 38.2 0.2 2.8e-09 37.1 0.2 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PLAC8 PF04749.15 MSTRG.20913.1_2 - 2.1e-11 44.6 22.2 4.8e-11 43.4 22.2 1.7 1 0 0 1 1 1 1 PLAC8 family Zip PF02535.20 MSTRG.2243.1_2 - 5.9e-48 163.6 2.0 6.5e-48 163.5 2.0 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter RNA_helicase PF00910.20 MSTRG.2243.1_3 - 0.11 12.8 0.4 0.14 12.4 0.4 1.2 1 0 0 1 1 1 0 RNA helicase Y_phosphatase PF00102.25 MSTRG.3271.2_2 - 5.1e-77 258.5 1.0 8.2e-77 257.8 0.3 1.7 2 0 0 2 2 2 1 Protein-tyrosine phosphatase SH2 PF00017.22 MSTRG.3271.2_2 - 2.2e-49 165.3 0.2 3.3e-24 84.6 0.1 2.5 2 0 0 2 2 2 2 SH2 domain DSPc PF00782.18 MSTRG.3271.2_2 - 0.00011 21.8 0.0 0.00036 20.2 0.0 1.9 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 MSTRG.3271.2_2 - 0.00045 20.3 0.0 0.00045 20.3 0.0 2.2 3 0 0 3 3 3 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.4 MSTRG.3271.2_2 - 0.006 16.4 0.1 0.023 14.5 0.0 1.9 2 0 0 2 2 2 1 Tyrosine phosphatase family C1-set PF07654.13 MSTRG.18673.1_1 - 1e-44 150.7 0.2 4e-14 52.7 0.0 4.2 4 0 0 4 4 4 4 Immunoglobulin C1-set domain Ig_3 PF13927.4 MSTRG.18673.1_1 - 4.6e-16 59.1 1.0 5.5e-07 30.0 0.0 4.6 4 0 0 4 4 4 3 Immunoglobulin domain C2-set_2 PF08205.10 MSTRG.18673.1_1 - 1.8e-11 43.8 0.6 0.016 15.2 0.0 4.3 4 0 0 4 4 4 3 CD80-like C2-set immunoglobulin domain ig PF00047.23 MSTRG.18673.1_1 - 1.6e-10 40.9 4.0 1.3e-06 28.3 0.1 4.5 4 1 0 4 4 4 2 Immunoglobulin domain I-set PF07679.14 MSTRG.18673.1_1 - 2.5e-06 27.3 0.0 6.7e-05 22.8 0.0 3.0 4 0 0 4 4 4 1 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.18673.1_1 - 2.9e-06 27.4 2.4 0.0042 17.3 0.2 4.4 4 1 0 4 4 4 1 Immunoglobulin domain Marek_A PF02124.13 MSTRG.18673.1_1 - 3e-05 23.8 0.3 0.12 12.1 0.0 2.3 2 0 0 2 2 2 2 Marek's disease glycoprotein A Sds3 PF08598.9 MSTRG.16762.2_1 - 2.3e-17 63.6 18.4 3.9e-17 62.9 18.4 1.3 1 1 0 1 1 1 1 Sds3-like Exonuc_VII_L PF02601.13 MSTRG.16762.2_1 - 0.46 9.9 6.6 0.6 9.5 6.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit V-set PF07686.15 MSTRG.2531.3_2 - 2.5e-05 24.3 0.0 3.8e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain INSC_LBD PF16748.3 MSTRG.2531.3_2 - 0.14 11.5 0.8 2 7.8 0.1 2.5 2 0 0 2 2 2 0 Inscuteable LGN-binding domain Proteasome PF00227.24 MSTRG.4237.2_3 - 2.9e-47 160.5 0.2 3.7e-47 160.2 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Cortexin PF11057.6 MSTRG.3595.1_2 - 1.1e-29 101.9 0.1 1.6e-29 101.5 0.1 1.2 1 0 0 1 1 1 1 Cortexin of kidney Myotub-related PF06602.12 MSTRG.13225.1_1 - 4.5e-44 150.7 0.0 5.3e-44 150.4 0.0 1.0 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain fn3 PF00041.19 MSTRG.214.2_3 - 4.3e-131 427.4 1.9 1.8e-14 53.7 0.0 9.4 9 0 0 9 9 9 9 Fibronectin type III domain I-set PF07679.14 MSTRG.214.2_3 - 1.6e-50 168.9 1.8 1.4e-11 44.1 0.0 6.0 4 1 0 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.214.2_3 - 1.7e-30 105.3 0.3 1.2e-06 28.9 0.0 5.3 4 1 0 4 4 4 4 Immunoglobulin domain Pur_ac_phosph_N PF16656.3 MSTRG.214.2_3 - 1.5e-16 60.6 0.4 0.14 12.6 0.0 9.2 9 1 0 9 9 9 4 Purple acid Phosphatase, N-terminal domain ig PF00047.23 MSTRG.214.2_3 - 5.8e-15 55.1 0.2 0.00038 20.5 0.0 5.7 5 1 1 6 6 6 4 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.214.2_3 - 9e-08 32.2 0.2 0.47 10.7 0.0 4.8 5 0 0 5 5 4 2 Immunoglobulin domain fn3_2 PF16893.3 MSTRG.214.2_3 - 1.6e-06 28.0 0.0 2 8.5 0.0 6.7 8 0 0 8 8 8 1 Fibronectin type III domain Receptor_2B4 PF11465.6 MSTRG.214.2_3 - 0.00025 21.1 0.1 0.88 9.7 0.0 4.7 4 2 1 5 5 5 1 Natural killer cell receptor 2B4 C2-set_2 PF08205.10 MSTRG.214.2_3 - 0.00062 19.7 0.2 5 7.1 0.0 4.4 4 0 0 4 4 4 1 CD80-like C2-set immunoglobulin domain Y_Y_Y PF07495.11 MSTRG.214.2_3 - 0.0046 16.7 0.2 60 3.6 0.0 5.8 7 0 0 7 7 7 0 Y_Y_Y domain Reeler PF02014.14 MSTRG.214.2_3 - 0.0063 17.1 0.0 52 4.5 0.0 5.9 6 0 0 6 6 6 0 Reeler domain GPI-anchored PF10342.7 MSTRG.214.2_3 - 0.0095 16.5 4.6 1.1 10.0 0.0 6.0 7 0 0 7 7 6 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family NAR2 PF16974.3 MSTRG.214.2_3 - 0.034 13.4 0.1 1.5 8.0 0.0 3.4 4 0 0 4 4 4 0 High-affinity nitrate transporter accessory CNDH2_M PF16869.3 MSTRG.21565.4_2 - 2 9.1 6.8 0.84 10.3 3.3 2.0 1 1 1 2 2 2 0 PF16858 LRR_9 PF14580.4 MSTRG.21565.4_3 - 8.1e-93 308.6 3.2 1.1e-92 308.2 3.2 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.4 MSTRG.21565.4_3 - 5.8e-07 29.0 4.5 1.6e-06 27.7 4.5 1.8 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.5 MSTRG.21565.4_3 - 0.0002 21.5 12.3 0.025 14.9 3.8 3.0 2 1 1 4 4 4 2 Leucine Rich repeats (2 copies) CSRNP_N PF16019.3 MSTRG.11104.1_1 - 4.5e-98 327.4 6.9 8.5e-98 326.5 6.9 1.4 1 0 0 1 1 1 1 Cysteine/serine-rich nuclear protein N-terminus APOBEC_N PF08210.9 MSTRG.1382.1_3 - 1.9e-47 161.4 0.3 2.7e-47 160.9 0.3 1.2 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC_C PF05240.12 MSTRG.1382.1_3 - 1.8e-25 88.5 0.1 3e-25 87.8 0.1 1.4 1 0 0 1 1 1 1 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 MSTRG.1382.1_3 - 0.009 15.7 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.4 MSTRG.1382.1_3 - 0.067 12.8 0.0 0.19 11.3 0.0 1.6 2 0 0 2 2 2 0 MafB19-like deaminase CAP_N PF01213.17 MSTRG.27349.1_3 - 2.9 7.1 7.6 7.1 5.9 7.6 1.6 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DC_STAMP PF07782.11 MSTRG.3666.1_3 - 9.1e-38 129.9 3.0 1e-37 129.7 3.0 1.0 1 0 0 1 1 1 1 DC-STAMP-like protein PXA PF02194.13 MSTRG.3666.1_3 - 0.0065 16.3 0.2 0.008 16.0 0.2 1.1 1 0 0 1 1 1 1 PXA domain MFS_1 PF07690.14 MSTRG.10207.1_3 - 6.9e-38 130.3 38.3 2.2e-27 95.8 17.4 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily RA PF00788.21 MSTRG.11611.1_1 - 1.5e-13 51.0 0.3 3.6e-13 49.8 0.3 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PH PF00169.27 MSTRG.11611.1_1 - 3.5e-11 43.4 0.4 6.3e-11 42.6 0.4 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 MSTRG.11611.1_1 - 0.0032 17.7 0.5 0.01 16.1 0.5 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain RBD PF02196.13 MSTRG.11611.1_1 - 0.0056 16.6 0.0 0.012 15.6 0.0 1.6 1 0 0 1 1 1 1 Raf-like Ras-binding domain PI3K_rbd PF00794.16 MSTRG.11611.1_1 - 0.027 14.5 0.1 0.057 13.5 0.1 1.5 1 0 0 1 1 1 0 PI3-kinase family, ras-binding domain HCO3_cotransp PF00955.19 MSTRG.19618.1_3 - 6.3e-77 259.4 2.1 9.1e-77 258.9 2.1 1.1 1 0 0 1 1 1 1 HCO3- transporter family Xan_ur_permease PF00860.18 MSTRG.19618.1_3 - 0.0035 16.0 0.3 0.0035 16.0 0.3 1.6 2 0 0 2 2 2 1 Permease family hDGE_amylase PF14701.4 MSTRG.12888.2_2 - 1.7e-161 538.0 0.0 2.3e-161 537.7 0.0 1.1 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.12 MSTRG.12888.2_2 - 7.1e-133 443.1 0.0 1e-132 442.6 0.0 1.2 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.4 MSTRG.12888.2_2 - 3.9e-89 298.7 0.0 6.2e-89 298.0 0.0 1.3 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.4 MSTRG.12888.2_2 - 6.8e-19 67.7 0.0 1.3e-18 66.8 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.22 MSTRG.12888.2_2 - 0.0034 16.9 0.0 0.0064 16.0 0.0 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain SAM_1 PF00536.28 MSTRG.6934.1_3 - 6.5e-15 55.2 0.0 1.4e-14 54.1 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 MSTRG.6934.1_3 - 3e-08 33.5 0.0 5.8e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PHC2_SAM_assoc PF16616.3 MSTRG.6934.1_3 - 0.00087 20.0 9.6 0.00087 20.0 9.6 3.5 3 1 0 3 3 3 1 Unstructured region on Polyhomeotic-like protein 1 and 2 SAM_PNT PF02198.14 MSTRG.6934.1_3 - 0.082 12.7 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Alpha_kinase PF02816.16 MSTRG.2394.1_1 - 2.9e-25 89.5 0.2 5.8e-25 88.5 0.2 1.5 1 0 0 1 1 1 1 Alpha-kinase family I-set PF07679.14 MSTRG.2394.1_1 - 6.4e-24 83.7 0.1 3.5e-16 58.9 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.2394.1_1 - 1.1e-15 57.9 1.7 1.1e-10 41.8 0.2 3.5 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.2394.1_1 - 6.1e-11 42.4 0.8 1.9e-06 28.0 0.4 3.2 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.10 MSTRG.2394.1_1 - 0.00037 20.4 0.4 0.0023 17.8 0.0 2.6 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 MSTRG.2394.1_1 - 0.0044 17.0 1.1 0.51 10.4 0.2 3.0 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.15 MSTRG.2394.1_1 - 0.011 15.8 1.7 2.9 8.0 0.7 3.7 2 1 0 2 2 2 0 Immunoglobulin V-set domain Integrin_alpha2 PF08441.10 MSTRG.13334.3_2 - 1.4e-39 136.2 9.5 2e-39 135.7 9.5 1.2 1 0 0 1 1 1 1 Integrin alpha RRM_1 PF00076.20 MSTRG.13595.6_1 - 0.00023 20.8 0.0 0.00045 19.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RING-like PF08746.9 MSTRG.13595.6_2 - 0.024 14.8 1.5 0.041 14.1 1.5 1.4 1 0 0 1 1 1 0 RING-like domain Laminin_G_2 PF02210.22 MSTRG.3301.1_2 - 1e-15 58.3 0.0 1.7e-15 57.5 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.21 MSTRG.3301.1_2 - 8.1e-15 55.1 0.0 1.1e-14 54.6 0.0 1.2 1 0 0 1 1 1 1 Laminin G domain EGF PF00008.25 MSTRG.3301.1_2 - 0.0015 18.6 8.6 0.0023 18.0 8.6 1.3 1 0 0 1 1 1 1 EGF-like domain Laminin_G_3 PF13385.4 MSTRG.3301.1_2 - 0.034 14.2 0.0 0.047 13.7 0.0 1.3 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily EGF_2 PF07974.11 MSTRG.3301.1_2 - 0.074 13.3 12.2 0.11 12.7 12.2 1.3 1 0 0 1 1 1 0 EGF-like domain RRM_7 PF16367.3 MSTRG.3301.1_2 - 0.13 12.3 0.0 0.31 11.1 0.0 1.7 2 0 0 2 2 2 0 RNA recognition motif DIOX_N PF14226.4 MSTRG.22501.4_3 - 1.9e-18 67.2 0.0 3.7e-18 66.3 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.18 MSTRG.22501.4_3 - 9.2e-14 51.6 0.0 2.1e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-RING_2 PF13639.4 MSTRG.19001.1_1 - 2.4e-12 46.8 9.9 2.4e-12 46.8 9.9 2.8 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.5 MSTRG.19001.1_1 - 1e-07 32.0 8.8 1e-07 32.0 8.8 3.3 4 0 0 4 4 3 1 RING-H2 zinc finger domain zf-RING_11 PF17123.3 MSTRG.19001.1_1 - 2.8e-07 30.0 6.1 2.8e-07 30.0 6.1 2.4 2 0 0 2 2 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.4 MSTRG.19001.1_1 - 7.2e-07 28.8 9.6 7.2e-07 28.8 9.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 MSTRG.19001.1_1 - 4.2e-06 26.4 9.2 4.2e-06 26.4 9.2 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 MSTRG.19001.1_1 - 5.3e-06 26.2 7.4 1.5e-05 24.7 7.4 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 MSTRG.19001.1_1 - 3.1e-05 23.6 7.4 7.2e-05 22.4 7.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.19001.1_1 - 0.0011 18.8 5.3 0.0041 17.0 5.3 2.1 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.4 MSTRG.19001.1_1 - 0.0038 16.9 7.4 0.014 15.1 7.4 2.0 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.5 MSTRG.19001.1_1 - 0.0053 16.7 3.7 0.0053 16.7 3.7 3.5 4 0 0 4 4 3 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.3 MSTRG.19001.1_1 - 0.24 10.9 7.3 0.61 9.6 7.3 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type RINGv PF12906.5 MSTRG.19001.1_1 - 0.81 9.7 9.5 2.4 8.2 9.5 1.9 1 0 0 1 1 1 0 RING-variant domain LEAP-2 PF07359.9 MSTRG.19001.1_2 - 0.00026 20.6 0.1 0.001 18.7 0.1 2.1 1 0 0 1 1 1 1 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) RSRP PF17069.3 MSTRG.8491.1_2 - 6.2 6.2 25.8 9.1 5.6 25.8 1.2 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 BTB PF00651.29 MSTRG.22760.1_2 - 4.4e-24 84.7 0.1 1.1e-23 83.5 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 MSTRG.22760.1_2 - 3.1e-14 52.4 57.4 4e-06 26.8 1.3 8.7 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.22760.1_2 - 1.3e-11 44.2 60.1 0.00023 21.6 1.0 9.1 9 0 0 9 9 8 7 C2H2-type zinc finger zf-met PF12874.5 MSTRG.22760.1_2 - 0.00096 19.3 23.7 1.3 9.4 0.5 7.1 6 0 0 6 6 6 2 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.4 MSTRG.22760.1_2 - 0.0017 18.6 4.3 0.0017 18.6 4.3 9.4 9 1 0 9 9 9 3 Zinc-finger double domain zf-C2H2_jaz PF12171.6 MSTRG.22760.1_2 - 0.017 15.3 0.2 0.017 15.3 0.2 8.1 9 0 0 9 9 8 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 MSTRG.22760.1_2 - 0.25 11.0 18.9 1.3 8.7 0.4 5.2 5 0 0 5 5 5 0 zinc-finger C2H2-type FYDLN_acid PF09538.8 MSTRG.22760.1_2 - 0.28 11.8 0.1 0.28 11.8 0.1 4.9 6 0 0 6 6 4 0 Protein of unknown function (FYDLN_acid) zinc_ribbon_2 PF13240.4 MSTRG.22760.1_2 - 0.53 9.9 8.5 5.8 6.6 0.3 4.0 3 0 0 3 3 3 0 zinc-ribbon domain zf-Di19 PF05605.10 MSTRG.22760.1_2 - 2 8.7 35.3 0.53 10.5 0.3 5.5 5 0 0 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding TF_Zn_Ribbon PF08271.10 MSTRG.22760.1_2 - 2.2 7.7 9.1 1.7 8.1 0.1 3.8 3 0 0 3 3 3 0 TFIIB zinc-binding zf-CHCC PF10276.7 MSTRG.22760.1_2 - 2.2 8.3 14.2 0.44 10.5 0.4 3.9 4 0 0 4 4 4 0 Zinc-finger domain zinc_ribbon_15 PF17032.3 MSTRG.22760.1_2 - 2.6 8.7 24.2 2 9.1 1.0 5.3 3 1 2 5 5 5 0 zinc-ribbon family ADK_lid PF05191.12 MSTRG.22760.1_2 - 3.4 7.6 17.9 0.94 9.4 0.0 5.1 5 1 0 5 5 5 0 Adenylate kinase, active site lid zf-C2H2_6 PF13912.4 MSTRG.22760.1_2 - 8 6.4 39.8 0.45 10.4 0.5 7.0 8 1 0 8 8 8 0 C2H2-type zinc finger FAD_binding_3 PF01494.17 MSTRG.4471.4_3 - 1.5e-05 24.4 0.0 2.3e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.12 MSTRG.4471.4_3 - 8.3e-05 21.8 0.0 0.00016 20.9 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 MSTRG.4471.4_3 - 0.00011 21.8 0.0 0.023 14.2 0.1 2.6 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.4 MSTRG.4471.4_3 - 0.00015 21.0 0.0 0.0003 20.0 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.4 MSTRG.4471.4_3 - 0.0024 17.9 0.0 0.0058 16.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.12 MSTRG.4471.4_3 - 0.0025 16.4 0.0 0.0048 15.5 0.0 1.4 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.22 MSTRG.4471.4_3 - 0.0036 16.3 0.1 0.012 14.6 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain NAD_binding_7 PF13241.4 MSTRG.4471.4_3 - 0.012 15.9 0.0 0.063 13.6 0.0 2.1 2 0 0 2 2 2 0 Putative NAD(P)-binding Pyr_redox PF00070.25 MSTRG.4471.4_3 - 0.043 14.2 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.19 MSTRG.4471.4_3 - 0.064 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ROKNT PF08067.9 MSTRG.5751.2_2 - 3.7e-15 55.8 3.6 6.6e-15 55.0 3.6 1.4 1 0 0 1 1 1 1 ROKNT (NUC014) domain KH_4 PF13083.4 MSTRG.5751.2_2 - 6e-05 22.7 0.1 9.2e-05 22.1 0.1 1.2 1 0 0 1 1 1 1 KH domain KH_1 PF00013.27 MSTRG.5751.2_2 - 0.00023 20.8 0.1 0.00038 20.1 0.1 1.3 1 0 0 1 1 1 1 KH domain KH_2 PF07650.15 MSTRG.5751.2_2 - 0.0025 17.5 0.1 0.0039 16.8 0.1 1.2 1 0 0 1 1 1 1 KH domain KH_1 PF00013.27 MSTRG.5751.2_3 - 5.8e-31 106.0 5.5 5.5e-19 67.6 1.7 2.3 2 0 0 2 2 2 2 KH domain KH_2 PF07650.15 MSTRG.5751.2_3 - 6.7e-09 35.3 0.3 0.0015 18.2 0.1 2.3 2 0 0 2 2 2 2 KH domain KH_5 PF13184.4 MSTRG.5751.2_3 - 0.013 15.4 1.7 0.9 9.5 0.3 2.4 2 0 0 2 2 2 0 NusA-like KH domain DJ-1_PfpI PF01965.22 MSTRG.5751.2_3 - 0.036 13.7 0.0 0.077 12.7 0.0 1.5 1 0 0 1 1 1 0 DJ-1/PfpI family KH_4 PF13083.4 MSTRG.5751.2_3 - 0.15 11.8 0.7 1.9 8.3 0.1 2.3 2 0 0 2 2 2 0 KH domain KN_motif PF12075.6 MSTRG.10594.1_1 - 3e-20 71.6 0.1 6.4e-20 70.5 0.1 1.6 1 0 0 1 1 1 1 KN motif Phage_GP20 PF06810.9 MSTRG.10594.1_1 - 0.031 13.9 5.4 0.16 11.6 0.8 2.5 2 0 0 2 2 2 0 Phage minor structural protein GP20 PBP5_C PF07943.11 MSTRG.10594.1_1 - 0.06 13.4 0.0 0.19 11.8 0.0 1.8 1 0 0 1 1 1 0 Penicillin-binding protein 5, C-terminal domain FlaC_arch PF05377.9 MSTRG.10594.1_1 - 0.14 12.4 0.9 20 5.5 0.1 2.7 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF2730 PF10805.6 MSTRG.10594.1_1 - 1.9 8.5 5.8 21 5.1 1.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) SlyX PF04102.10 MSTRG.10594.1_1 - 4.7 7.8 8.9 2.3 8.7 2.7 2.8 2 0 0 2 2 2 0 SlyX TolA_bind_tri PF16331.3 MSTRG.10594.1_1 - 7.2 6.6 11.2 0.14 12.1 2.6 2.5 2 1 0 2 2 2 0 TolA binding protein trimerisation Ank_2 PF12796.5 MSTRG.10594.1_2 - 6.9e-40 135.4 12.7 4.6e-15 55.8 0.0 3.3 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.28 MSTRG.10594.1_2 - 1.6e-20 72.5 0.0 0.00012 22.2 0.0 4.8 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.4 MSTRG.10594.1_2 - 1.7e-20 72.7 3.7 6.5e-11 42.2 0.0 4.4 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 MSTRG.10594.1_2 - 4.6e-18 65.2 1.5 7.8e-08 32.6 0.0 4.6 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.10594.1_2 - 5.7e-18 63.0 0.1 0.00013 22.0 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat DUF4050 PF13259.4 MSTRG.10594.1_2 - 3.6 7.7 7.3 7.2 6.7 7.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) HMG_box_2 PF09011.8 MSTRG.13228.1_3 - 1.1e-43 147.5 10.4 4.1e-28 97.6 3.5 2.3 2 0 0 2 2 2 2 HMG-box domain HMG_box PF00505.17 MSTRG.13228.1_3 - 8.4e-42 141.3 9.1 2.9e-26 91.6 1.0 2.3 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_5 PF14887.4 MSTRG.13228.1_3 - 0.033 14.0 12.5 0.7 9.8 5.5 2.3 2 0 0 2 2 2 0 HMG (high mobility group) box 5 Nucleo_P87 PF07267.9 MSTRG.13228.1_3 - 1.8 7.2 7.0 2.1 7.0 7.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 YABBY PF04690.11 MSTRG.13228.1_3 - 6.4 7.2 11.5 0.088 13.2 1.4 2.4 2 1 0 2 2 2 0 YABBY protein DNA_pol_phi PF04931.11 MSTRG.13228.1_3 - 9.5 4.1 16.0 13 3.6 16.0 1.2 1 0 0 1 1 1 0 DNA polymerase phi 7tm_1 PF00001.19 MSTRG.26234.2_1 - 1.7e-25 89.6 3.4 1.7e-25 89.6 3.4 2.6 3 0 0 3 3 3 2 7 transmembrane receptor (rhodopsin family) Linker_histone PF00538.17 MSTRG.41.1_3 - 2.8e-21 75.5 3.0 2.8e-21 75.5 3.0 2.3 2 0 0 2 2 2 1 linker histone H1 and H5 family UPF0180 PF03698.11 MSTRG.41.1_3 - 0.12 12.5 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0180) Sprouty PF05210.11 MSTRG.9728.1_2 - 9.8e-31 106.3 33.1 9.8e-31 106.3 33.1 3.0 1 1 1 2 2 2 1 Sprouty protein (Spry) Cadherin PF00028.15 MSTRG.15820.1_2 - 4.9e-34 116.5 0.3 3.8e-23 81.6 0.2 2.1 2 0 0 2 2 2 2 Cadherin domain Cadherin_2 PF08266.10 MSTRG.15820.1_2 - 9.6e-06 25.2 0.0 0.00031 20.4 0.0 2.2 2 0 0 2 2 2 1 Cadherin-like Cadherin_3 PF16184.3 MSTRG.15820.1_2 - 0.0013 18.6 3.8 0.0025 17.7 0.1 2.5 3 0 0 3 3 3 1 Cadherin-like Collagen PF01391.16 MSTRG.19251.1_1 - 8.5e-18 63.7 98.8 1.6e+04 -18.4 98.8 3.3 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) CTD_bind PF04818.11 MSTRG.22451.2_3 - 2.2e-17 63.5 0.1 6.4e-17 62.0 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_1 PF00076.20 MSTRG.22451.2_3 - 2.5e-06 27.1 0.0 4.4e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4523 PF15023.4 MSTRG.22451.2_3 - 0.075 12.7 0.1 0.15 11.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) GIT1_C PF12205.6 MSTRG.17115.1_3 - 9.6e-44 148.1 1.6 9.6e-44 148.1 1.6 2.0 2 0 0 2 2 2 1 G protein-coupled receptor kinase-interacting protein 1 C term GIT_CC PF16559.3 MSTRG.17115.1_3 - 1.5e-29 101.7 4.1 1.5e-29 101.7 4.1 1.8 2 0 0 2 2 2 1 GIT coiled-coil Rho guanine nucleotide exchange factor ArfGap PF01412.16 MSTRG.17115.1_3 - 1.2e-25 89.6 0.0 2.7e-25 88.6 0.0 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf GIT_SHD PF08518.9 MSTRG.17115.1_3 - 4e-24 83.8 6.1 1.4e-12 46.9 0.5 2.5 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT Ank_2 PF12796.5 MSTRG.17115.1_3 - 7e-10 39.2 0.0 1.4e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.17115.1_3 - 7.5e-08 32.6 0.0 3.1e-06 27.5 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.4 MSTRG.17115.1_3 - 3.7e-07 30.2 0.0 1.6e-06 28.2 0.0 2.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.17115.1_3 - 0.00082 19.6 0.0 0.0071 16.6 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.4 MSTRG.17115.1_3 - 0.026 14.9 0.0 13 6.6 0.0 3.2 3 0 0 3 3 2 0 Ankyrin repeat Shugoshin_N PF07558.9 MSTRG.17115.1_3 - 0.031 14.0 2.6 0.071 12.9 2.6 1.6 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region T7SS_ESX_EspC PF10824.6 MSTRG.17115.1_3 - 0.26 11.6 1.8 0.41 11.0 0.1 2.1 2 0 0 2 2 2 0 Excreted virulence factor EspC, type VII ESX diderm bZIP_1 PF00170.19 MSTRG.17115.1_3 - 0.63 10.0 3.9 1.6 8.8 3.9 1.7 1 0 0 1 1 1 0 bZIP transcription factor DUF3347 PF11827.6 MSTRG.17115.1_3 - 0.72 9.9 4.6 1.6 8.8 4.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) DUF3450 PF11932.6 MSTRG.17115.1_3 - 2.8 7.0 7.5 5.4 6.1 7.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Peptidase_M16 PF00675.18 MSTRG.16837.1_2 - 8.2e-40 136.1 0.0 2e-39 134.8 0.0 1.6 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.19 MSTRG.16837.1_2 - 4.4e-38 131.0 0.0 6.7e-38 130.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain DUF2695 PF10905.6 MSTRG.16837.1_2 - 0.029 14.5 0.0 0.071 13.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2695) GSH_synth_ATP PF03917.15 MSTRG.3108.1_2 - 4.1e-46 157.3 0.1 5.2e-46 157.0 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain Stomoxyn PF11585.6 MSTRG.3108.1_2 - 0.15 11.9 0.0 1.5 8.8 0.0 2.2 2 0 0 2 2 2 0 Insect antimicrobial peptide, stomoxyn Transket_pyr PF02779.22 MSTRG.21374.2_2 - 0.00025 20.7 0.0 0.00038 20.1 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Tme5_EGF_like PF09064.8 MSTRG.21374.2_2 - 0.1 12.3 0.3 0.21 11.4 0.3 1.4 1 0 0 1 1 1 0 Thrombomodulin like fifth domain, EGF-like GOLGA2L5 PF15070.4 MSTRG.13133.5_3 - 4.1e-275 914.2 65.0 4.1e-275 914.2 65.0 2.2 2 0 0 2 2 2 1 Putative golgin subfamily A member 2-like protein 5 Atg14 PF10186.7 MSTRG.13133.5_3 - 0.00032 19.8 3.4 0.00032 19.8 3.4 6.9 2 2 4 6 6 6 2 Vacuolar sorting 38 and autophagy-related subunit 14 Acetyltransf_1 PF00583.23 MSTRG.21719.2_2 - 1.2e-12 47.9 0.0 2.1e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.5 MSTRG.21719.2_2 - 6.5e-08 32.8 0.0 1.4e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.8 MSTRG.21719.2_2 - 2.2e-06 27.4 0.0 4.1e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.5 MSTRG.21719.2_2 - 6.2e-06 26.0 0.1 2.3e-05 24.2 0.1 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Epimerase PF01370.19 MSTRG.16467.1_2 - 4.2e-21 75.4 0.0 6.6e-21 74.7 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 MSTRG.16467.1_2 - 2e-15 56.9 0.0 3.8e-15 56.0 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.15 MSTRG.16467.1_2 - 3e-08 33.0 0.0 4.4e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.17 MSTRG.16467.1_2 - 8.1e-07 28.2 0.0 1.1e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.10 MSTRG.16467.1_2 - 1.4e-05 24.3 0.2 4.8e-05 22.5 0.0 1.9 2 1 0 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.13 MSTRG.16467.1_2 - 0.0099 14.9 0.0 0.046 12.7 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein DUF1100 PF06500.9 MSTRG.16467.1_2 - 0.048 12.3 0.0 0.81 8.3 0.0 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1100) KR PF08659.8 MSTRG.16467.1_2 - 0.12 12.1 0.1 0.39 10.5 0.0 1.7 2 0 0 2 2 2 0 KR domain Ig_3 PF13927.4 MSTRG.23360.1_1 - 2.8e-40 136.7 10.3 3.8e-11 43.3 0.0 5.6 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.23360.1_1 - 1.1e-32 112.0 2.6 1.9e-09 37.6 0.0 6.1 5 2 0 5 5 5 4 Immunoglobulin domain I-set PF07679.14 MSTRG.23360.1_1 - 5.9e-31 106.3 12.1 1.2e-06 28.3 0.1 6.6 5 3 0 5 5 5 5 Immunoglobulin I-set domain ig PF00047.23 MSTRG.23360.1_1 - 2e-23 82.2 5.2 2.5e-05 24.2 0.0 6.2 5 1 0 5 5 5 4 Immunoglobulin domain C2-set_2 PF08205.10 MSTRG.23360.1_1 - 4.6e-23 81.0 0.6 1.4e-17 63.4 0.0 4.2 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain V-set PF07686.15 MSTRG.23360.1_1 - 7.7e-18 64.5 6.7 4.7e-10 39.5 0.0 6.1 5 2 1 6 6 6 2 Immunoglobulin V-set domain Ig_5 PF16681.3 MSTRG.23360.1_1 - 6.8e-09 35.9 0.4 0.055 13.8 0.0 4.5 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 MSTRG.23360.1_1 - 1.1e-07 31.9 0.9 0.17 12.2 0.0 4.3 4 0 0 4 4 4 2 T-cell surface glycoprotein CD3 delta chain DUF912 PF06024.10 MSTRG.23360.1_1 - 0.00059 20.0 0.0 0.0016 18.6 0.0 1.8 1 0 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) C1-set PF07654.13 MSTRG.23360.1_1 - 0.00093 19.5 4.0 0.024 15.0 0.0 3.9 4 1 0 4 4 4 1 Immunoglobulin C1-set domain DUF3377 PF11857.6 MSTRG.23360.1_1 - 0.0016 18.2 1.9 0.19 11.6 0.1 2.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3377) Izumo-Ig PF16706.3 MSTRG.23360.1_1 - 0.0026 17.6 0.0 2.7 8.0 0.0 4.1 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain CD34_antigen PF06365.10 MSTRG.23360.1_1 - 0.0026 17.3 0.0 0.0054 16.2 0.0 1.5 1 0 0 1 1 1 1 CD34/Podocalyxin family DUF3915 PF13054.4 MSTRG.23360.1_1 - 0.0098 15.7 4.4 0.027 14.3 4.4 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3915) TMEM154 PF15102.4 MSTRG.23360.1_1 - 0.012 15.4 0.2 0.032 14.0 0.2 1.7 1 0 0 1 1 1 0 TMEM154 protein family 7TM_GPCR_Srw PF10324.7 MSTRG.23360.1_1 - 0.018 14.2 0.0 0.028 13.6 0.0 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw Amnionless PF14828.4 MSTRG.23360.1_1 - 0.024 13.4 0.2 0.042 12.6 0.2 1.3 1 0 0 1 1 1 0 Amnionless Protocadherin PF08374.9 MSTRG.23360.1_1 - 0.028 14.3 0.7 0.028 14.3 0.7 2.0 2 0 0 2 2 2 0 Protocadherin DUF4448 PF14610.4 MSTRG.23360.1_1 - 0.063 12.9 0.1 0.34 10.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) ERGIC_N PF13850.4 MSTRG.23360.1_1 - 0.08 13.2 0.0 0.41 10.9 0.0 2.1 2 0 0 2 2 2 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) S1FA PF04689.11 MSTRG.23360.1_1 - 0.21 11.6 0.1 0.21 11.6 0.1 2.5 3 0 0 3 3 2 0 DNA binding protein S1FA Atrophin-1 PF03154.13 MSTRG.23360.1_1 - 0.38 8.9 9.6 0.7 8.0 9.6 1.3 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.4 MSTRG.23360.1_2 - 0.056 13.3 7.1 0.05 13.5 5.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) DUF3915 PF13054.4 MSTRG.23360.1_3 - 0.0073 16.1 2.1 0.0073 16.1 2.1 3.3 3 0 0 3 3 3 1 Protein of unknown function (DUF3915) Mating_C PF12737.5 MSTRG.23360.1_3 - 4.2 6.4 8.7 7.3 5.6 8.7 1.2 1 0 0 1 1 1 0 C-terminal domain of homeodomain 1 Sema PF01403.17 MSTRG.24645.1_2 - 3.3e-26 91.9 0.0 4.2e-26 91.6 0.0 1.1 1 0 0 1 1 1 1 Sema domain Dimer_Tnp_hAT PF05699.12 MSTRG.21244.1_3 - 0.018 14.7 0.0 0.031 13.9 0.0 1.4 1 0 0 1 1 1 0 hAT family C-terminal dimerisation region Connexin PF00029.17 MSTRG.10781.1_3 - 3.4e-82 275.5 0.0 6.5e-82 274.5 0.0 1.5 2 0 0 2 2 2 1 Connexin Ribosomal_L39 PF00832.18 MSTRG.10255.2_1 - 4e-23 80.6 11.1 4e-23 80.6 11.1 2.1 3 0 0 3 3 3 1 Ribosomal L39 protein DUF2353 PF09789.7 MSTRG.11528.1_3 - 1e-107 360.1 29.9 1.3e-107 359.8 29.9 1.1 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) CENP-F_leu_zip PF10473.7 MSTRG.11528.1_3 - 0.028 14.3 0.4 0.028 14.3 0.4 4.5 3 1 1 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CALCOCO1 PF07888.9 MSTRG.11528.1_3 - 0.75 8.2 29.0 0.02 13.4 19.7 2.2 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like APG6 PF04111.10 MSTRG.11528.1_3 - 2 7.6 19.0 1.2e+02 1.7 19.0 2.4 1 1 0 1 1 1 0 Autophagy protein Apg6 Fez1 PF06818.13 MSTRG.11528.1_3 - 2.3 8.5 25.8 0.33 11.2 0.3 3.2 2 1 0 2 2 2 0 Fez1 Rootletin PF15035.4 MSTRG.11528.1_3 - 9.5 6.1 23.9 1.1e+02 2.6 20.9 3.0 2 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion FAA_hydrolase PF01557.16 MSTRG.1975.1_1 - 1.4e-70 237.2 0.0 1.7e-70 236.9 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Kinesin PF00225.21 MSTRG.17273.1_3 - 2.1e-32 112.3 0.0 2.1e-32 112.3 0.0 3.0 3 0 0 3 3 3 1 Kinesin motor domain AATase PF07247.10 MSTRG.17273.1_3 - 0.051 12.2 0.6 0.088 11.4 0.6 1.3 1 0 0 1 1 1 0 Alcohol acetyltransferase Ras PF00071.20 MSTRG.20091.1_3 - 1.5e-51 174.1 0.6 2e-51 173.7 0.6 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.20091.1_3 - 4.1e-19 68.8 0.0 1e-18 67.6 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.20091.1_3 - 5e-10 39.0 0.2 7.2e-10 38.5 0.2 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 MSTRG.20091.1_3 - 1.8e-07 31.1 1.0 0.00035 20.4 0.3 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 MSTRG.20091.1_3 - 2.6e-05 23.7 0.2 5.6e-05 22.6 0.1 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 MSTRG.20091.1_3 - 0.00063 19.7 0.0 0.00099 19.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase EIAV_Rev PF11129.6 MSTRG.20091.1_3 - 0.13 12.3 0.3 0.22 11.6 0.3 1.3 1 0 0 1 1 1 0 Rev protein of equine infectious anaemia virus CLASP_N PF12348.6 MSTRG.12344.1_1 - 2.8e-20 72.7 0.1 3.5e-07 29.9 0.1 3.7 3 0 0 3 3 3 3 CLASP N terminal HEAT PF02985.20 MSTRG.12344.1_1 - 5.9e-11 41.5 2.2 3.7 7.9 0.0 8.2 8 0 0 8 8 8 4 HEAT repeat HEAT_2 PF13646.4 MSTRG.12344.1_1 - 4.4e-08 33.3 0.1 0.58 10.4 0.0 5.3 4 1 1 5 5 5 3 HEAT repeats Cnd1 PF12717.5 MSTRG.12344.1_1 - 9.8e-06 25.5 0.5 11 5.8 0.0 5.6 4 1 1 6 6 6 3 non-SMC mitotic condensation complex subunit 1 Cohesin_HEAT PF12765.5 MSTRG.12344.1_1 - 0.024 14.7 1.5 17 5.6 0.0 4.3 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion AIP3 PF03915.11 MSTRG.18196.2_3 - 0.022 13.7 2.3 0.032 13.2 2.3 1.2 1 0 0 1 1 1 0 Actin interacting protein 3 DUF1192 PF06698.9 MSTRG.18196.2_3 - 0.1 12.6 5.0 0.095 12.6 0.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1192) Mod_r PF07200.11 MSTRG.18196.2_3 - 0.17 11.9 5.6 0.67 9.9 2.2 2.3 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein MerR-DNA-bind PF09278.9 MSTRG.18196.2_3 - 0.22 11.9 0.2 0.22 11.9 0.2 3.3 3 0 0 3 3 3 0 MerR, DNA binding DUF5082 PF16888.3 MSTRG.18196.2_3 - 0.34 11.1 5.8 1.7 8.9 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF5082) CENP-F_leu_zip PF10473.7 MSTRG.18196.2_3 - 0.47 10.4 10.3 1.1 9.1 6.5 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Filament PF00038.19 MSTRG.18196.2_3 - 0.62 9.5 6.6 1.1 8.6 2.6 2.1 2 0 0 2 2 2 0 Intermediate filament protein TPR_MLP1_2 PF07926.10 MSTRG.18196.2_3 - 0.7 9.8 9.9 4.4 7.2 0.0 2.8 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein IncA PF04156.12 MSTRG.18196.2_3 - 3 7.4 13.6 7.7 6.1 0.4 2.5 1 1 0 2 2 2 0 IncA protein FliJ PF02050.14 MSTRG.18196.2_3 - 4 7.6 11.6 7.4 6.7 0.1 3.1 2 1 0 2 2 2 0 Flagellar FliJ protein YscO PF07321.10 MSTRG.18196.2_3 - 4.8 7.0 14.1 23 4.8 9.8 2.7 2 1 0 2 2 2 0 Type III secretion protein YscO ZapB PF06005.10 MSTRG.18196.2_3 - 5 7.5 12.7 5.9 7.3 0.1 2.9 2 1 0 2 2 2 0 Cell division protein ZapB Sulfotransfer_1 PF00685.25 MSTRG.16302.1_1 - 3.4e-36 125.0 0.0 3.8e-36 124.8 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 MSTRG.16302.1_1 - 2.2e-13 51.0 0.0 3.2e-13 50.4 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_2 PF03567.12 MSTRG.16302.1_1 - 0.0018 18.1 0.0 0.033 14.0 0.0 2.1 2 0 0 2 2 2 1 Sulfotransferase family RRM_1 PF00076.20 MSTRG.4152.1_3 - 3.1e-08 33.2 0.1 7.7e-08 31.9 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PDZ PF00595.22 MSTRG.18728.1_2 - 4.8e-46 154.9 5.3 1.3e-17 63.8 0.4 3.6 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.18728.1_2 - 1.1e-13 51.2 0.5 0.00017 21.7 0.1 3.6 3 0 0 3 3 3 3 PDZ domain Ribosomal_60s PF00428.17 MSTRG.9961.1_2 - 0.29 11.6 5.4 0.5 10.8 5.4 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein S1 PF00575.21 MSTRG.9961.1_3 - 3.2e-11 43.3 0.6 6.6e-11 42.3 0.6 1.4 1 0 0 1 1 1 1 S1 RNA binding domain Ribosomal_60s PF00428.17 MSTRG.9961.1_3 - 0.34 11.3 5.4 0.79 10.2 5.4 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein DPPIV_N PF00930.19 MSTRG.23471.3_2 - 1.8e-23 82.8 0.0 2.5e-23 82.3 0.0 1.1 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region DPPIV_N PF00930.19 MSTRG.23471.3_3 - 2.8e-63 213.7 0.0 3.7e-63 213.3 0.0 1.1 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.19 MSTRG.23471.3_3 - 8.6e-48 162.5 0.0 1.4e-47 161.8 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.16 MSTRG.23471.3_3 - 5.1e-08 32.7 0.0 9.1e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.18 MSTRG.23471.3_3 - 0.00014 21.4 0.0 0.00026 20.6 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.5 MSTRG.23471.3_3 - 0.0031 18.0 0.0 0.0089 16.5 0.0 1.8 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.18 MSTRG.23471.3_3 - 0.013 15.1 0.6 0.12 11.8 0.4 2.6 2 1 0 2 2 2 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 MSTRG.23471.3_3 - 0.031 13.4 0.0 0.072 12.2 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 AXE1 PF05448.10 MSTRG.23471.3_3 - 0.1 11.1 0.0 0.85 8.1 0.0 2.1 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) Pyr_redox_2 PF07992.12 MSTRG.23510.1_2 - 4.1e-30 104.9 0.5 1.7e-15 56.9 0.4 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.25 MSTRG.23510.1_2 - 0.0017 18.8 1.8 2.4 8.6 0.0 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.4 MSTRG.23510.1_2 - 0.0048 16.0 0.5 1.1 8.2 0.0 2.7 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.4 MSTRG.23510.1_2 - 0.0048 16.8 0.3 1.8 8.4 0.1 2.8 2 1 0 3 3 3 2 FAD-NAD(P)-binding DAO PF01266.22 MSTRG.23510.1_2 - 0.031 13.8 0.3 0.13 11.7 0.2 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase GIDA PF01134.20 MSTRG.23510.1_2 - 0.051 12.5 3.2 0.73 8.7 0.0 2.6 2 1 1 3 3 3 0 Glucose inhibited division protein A NAD_binding_8 PF13450.4 MSTRG.23510.1_2 - 0.061 13.4 0.1 0.16 12.1 0.1 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.10 MSTRG.23510.1_2 - 0.17 10.8 0.0 0.54 9.1 0.0 1.7 2 0 0 2 2 2 0 Lycopene cyclase protein RabGAP-TBC PF00566.16 MSTRG.3447.1_1 - 1.9e-12 47.2 0.0 2.4e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain 3-alpha PF03475.12 MSTRG.3447.1_1 - 0.091 12.5 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 3-alpha domain A_deaminase PF00962.20 MSTRG.25111.1_1 - 7.5e-29 101.0 0.1 9.8e-29 100.6 0.1 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase 5-nucleotidase PF06189.10 MSTRG.25755.3_2 - 2.5e-78 262.5 0.0 1.4e-62 210.9 0.0 2.2 1 1 1 2 2 2 2 5'-nucleotidase CBM_21 PF03370.11 MSTRG.16642.2_2 - 1e-28 99.6 0.2 2e-28 98.6 0.1 1.5 2 0 0 2 2 2 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.3 MSTRG.16642.2_2 - 1.3e-16 60.8 0.1 2.4e-16 59.9 0.1 1.4 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) SLD5_C PF16922.3 MSTRG.16642.2_3 - 5.3e-17 61.6 0.0 8.7e-17 60.9 0.0 1.4 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.9 MSTRG.16642.2_3 - 0.00013 22.2 0.2 0.00025 21.4 0.2 1.4 1 0 0 1 1 1 1 GINS complex protein Thioredoxin PF00085.18 MSTRG.26007.2_2 - 8.4e-26 89.8 0.0 1.2e-25 89.2 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.4 MSTRG.26007.2_2 - 1.4e-05 25.0 0.0 2.7e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.4 MSTRG.26007.2_2 - 2.8e-05 24.4 0.0 0.001 19.3 0.0 2.4 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_3 PF13192.4 MSTRG.26007.2_2 - 0.00056 19.8 0.6 0.0042 17.0 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin domain Thioredoxin_9 PF14595.4 MSTRG.26007.2_2 - 0.0033 17.0 0.0 0.0049 16.5 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin HyaE PF07449.9 MSTRG.26007.2_2 - 0.05 13.4 0.0 0.078 12.8 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Thioredoxin_8 PF13905.4 MSTRG.26007.2_2 - 0.071 13.3 0.0 0.64 10.3 0.0 2.1 1 1 1 2 2 2 0 Thioredoxin-like DSBA PF01323.18 MSTRG.26007.2_2 - 0.16 11.6 0.1 2.6 7.7 0.0 1.9 1 1 1 2 2 2 0 DSBA-like thioredoxin domain JUPITER PF17054.3 MSTRG.28399.1_3 - 1.2e-07 31.4 0.0 1.5e-07 31.1 0.0 1.0 1 0 0 1 1 1 1 Microtubule-Associated protein Jupiter dsrm PF00035.24 MSTRG.25462.1_2 - 6.8e-05 23.3 0.1 0.00011 22.7 0.1 1.3 1 0 0 1 1 1 1 Double-stranded RNA binding motif Dus PF01207.15 MSTRG.25462.1_2 - 0.058 12.3 0.0 0.099 11.6 0.0 1.4 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) PhoLip_ATPase_C PF16212.3 MSTRG.24019.1_3 - 5.8e-79 265.2 24.9 7.7e-79 264.8 24.9 1.2 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.24 MSTRG.24019.1_3 - 2.3e-08 34.5 0.0 5.6e-05 23.4 0.0 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.10 MSTRG.24019.1_3 - 0.00052 19.7 0.0 0.0012 18.6 0.0 1.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase F-box-like PF12937.5 MSTRG.27169.1_2 - 1.1e-06 28.3 0.6 2.5e-06 27.1 0.1 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.31 MSTRG.27169.1_2 - 3.6e-05 23.4 0.0 3.6e-05 23.4 0.0 2.0 2 0 0 2 2 2 1 F-box domain BTK PF00779.17 MSTRG.27169.1_2 - 0.00026 20.6 0.2 0.00068 19.3 0.2 1.7 1 0 0 1 1 1 1 BTK motif EF-hand_1 PF00036.30 MSTRG.2192.1_3 - 3.4e-15 54.2 3.2 8.9e-07 27.9 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.4 MSTRG.2192.1_3 - 4.2e-15 55.8 3.8 1.6e-10 41.2 0.7 2.3 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.2192.1_3 - 5e-13 47.7 2.2 8.6e-06 25.2 0.1 4.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.4 MSTRG.2192.1_3 - 1.7e-09 36.6 2.5 0.00029 20.1 0.1 3.7 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.4 MSTRG.2192.1_3 - 1.5e-07 31.0 0.1 0.01 15.5 0.0 2.9 2 1 1 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.7 MSTRG.2192.1_3 - 0.00083 19.5 1.7 0.16 12.1 0.2 3.3 1 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 MSTRG.2192.1_3 - 0.0054 16.5 0.8 0.88 9.4 0.1 2.6 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand Neur_chan_LBD PF02931.21 MSTRG.9445.1_2 - 4.5e-50 169.9 0.2 7.3e-50 169.3 0.2 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 MSTRG.9445.1_2 - 3.2e-30 105.8 7.8 5.1e-30 105.2 6.8 1.8 1 1 1 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region AROS PF15684.3 MSTRG.9445.1_2 - 0.03 14.8 0.1 0.056 13.9 0.1 1.4 1 0 0 1 1 1 0 Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1 LRR_6 PF13516.4 MSTRG.9971.1_2 - 6e-18 63.2 23.7 0.00094 18.9 0.0 8.3 8 0 0 8 8 8 6 Leucine Rich repeat F-box-like PF12937.5 MSTRG.9971.1_2 - 4.4e-13 48.7 0.3 1.3e-12 47.3 0.3 1.8 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.5 MSTRG.9971.1_2 - 4.7e-10 39.4 13.3 0.085 13.2 1.4 6.9 2 1 6 10 10 10 8 Leucine Rich repeats (2 copies) F-box PF00646.31 MSTRG.9971.1_2 - 2.4e-08 33.5 0.3 9.3e-08 31.6 0.3 2.1 1 0 0 1 1 1 1 F-box domain LRR_1 PF00560.31 MSTRG.9971.1_2 - 0.0035 17.5 19.0 18 6.2 0.1 8.7 8 1 0 8 8 8 1 Leucine Rich Repeat F-box_4 PF15966.3 MSTRG.9971.1_2 - 0.015 15.0 2.1 0.034 13.9 0.0 2.6 3 0 0 3 3 3 0 F-box LRR_8 PF13855.4 MSTRG.9971.1_2 - 0.19 11.4 7.7 6.5 6.5 0.8 4.8 4 2 2 6 6 6 0 Leucine rich repeat Pkinase_Tyr PF07714.15 MSTRG.14733.1_2 - 5.2e-15 55.3 0.0 5.2e-15 55.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.14733.1_2 - 1.8e-09 37.2 0.0 1.9e-09 37.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Myelin_PLP PF01275.17 MSTRG.20153.1_2 - 1.2e-95 319.7 21.8 1.8e-95 319.2 21.8 1.2 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) EI24 PF07264.9 MSTRG.20153.1_2 - 0.29 11.2 10.7 0.81 9.8 10.7 1.7 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) DUF2244 PF10003.7 MSTRG.20153.1_2 - 3.2 7.3 4.7 28 4.3 1.1 2.7 3 0 0 3 3 3 0 Integral membrane protein (DUF2244) Lipocalin PF00061.21 MSTRG.8800.2_3 - 2.1e-21 76.5 3.8 3e-21 76.0 3.8 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 MSTRG.8800.2_3 - 0.021 14.6 1.8 0.032 14.0 1.8 1.2 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family Fam20C PF06702.10 MSTRG.27682.2_2 - 4.8e-64 216.0 0.0 6.8e-64 215.5 0.0 1.2 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 SH3_9 PF14604.4 MSTRG.27682.2_2 - 3.2e-09 36.3 0.0 7.7e-09 35.1 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.27682.2_2 - 4.6e-06 26.0 0.0 8e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 SH3 domain IMD PF08397.9 MSTRG.27682.2_2 - 2.8e-05 23.5 0.1 4.1e-05 22.9 0.1 1.2 1 0 0 1 1 1 1 IRSp53/MIM homology domain SH3_2 PF07653.15 MSTRG.27682.2_2 - 0.00026 20.5 0.0 0.00052 19.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain PI3_PI4_kinase PF00454.25 MSTRG.27682.2_2 - 0.019 14.7 0.3 0.032 13.9 0.3 1.3 1 0 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase IMD PF08397.9 MSTRG.27682.2_3 - 1.5e-28 99.5 0.1 2.1e-28 99.1 0.1 1.1 1 0 0 1 1 1 1 IRSp53/MIM homology domain BAR_3 PF16746.3 MSTRG.27682.2_3 - 0.0017 17.9 0.1 0.0024 17.4 0.1 1.1 1 0 0 1 1 1 1 BAR domain of APPL family Band_7 PF01145.23 MSTRG.27682.2_3 - 0.22 11.4 1.0 0.32 10.9 1.0 1.1 1 0 0 1 1 1 0 SPFH domain / Band 7 family DUF1682 PF07946.12 MSTRG.27308.6_2 - 4.3 6.3 7.3 6.4 5.7 7.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Surp PF01805.18 MSTRG.9390.1_3 - 7.8e-17 60.9 0.5 1.7e-16 59.8 0.5 1.6 1 0 0 1 1 1 1 Surp module RRM_1 PF00076.20 MSTRG.9390.1_3 - 1.2e-10 40.9 0.0 2.8e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) cwf21 PF08312.10 MSTRG.9390.1_3 - 2.1e-10 40.5 4.1 6.2e-10 38.9 4.1 1.9 1 0 0 1 1 1 1 cwf21 domain CTD_bind PF04818.11 MSTRG.9390.1_3 - 1.9e-05 25.3 0.2 6.9e-05 23.5 0.2 2.1 1 0 0 1 1 1 1 RNA polymerase II-binding domain. CTK3 PF12243.6 MSTRG.9390.1_3 - 0.00019 21.3 1.2 0.00035 20.4 0.4 1.8 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 Sec8_exocyst PF04048.12 MSTRG.15346.1_2 - 1.4e-16 60.6 1.0 1.4e-16 60.6 1.0 2.9 3 0 0 3 3 3 1 Sec8 exocyst complex component specific domain Vps54_N PF10475.7 MSTRG.15346.1_2 - 0.0019 17.4 3.7 0.0019 17.4 3.7 3.0 3 0 0 3 3 3 1 Vacuolar-sorting protein 54, of GARP complex COG5 PF10392.7 MSTRG.15346.1_2 - 0.0041 17.2 3.0 0.0041 17.2 3.0 3.5 3 1 0 3 3 3 1 Golgi transport complex subunit 5 PEP-utilisers_N PF05524.11 MSTRG.15346.1_2 - 0.13 12.3 0.3 0.93 9.5 0.0 2.6 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal Trp_leader2 PF08056.9 MSTRG.27926.1_3 - 0.81 9.6 5.6 1.5 8.7 5.6 1.5 1 0 0 1 1 1 0 Tryptophan operon leader peptide Pkinase PF00069.23 MSTRG.26284.2_1 - 9.5e-75 251.2 0.1 1.9e-74 250.3 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.26284.2_1 - 4e-34 117.9 0.0 5.7e-34 117.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.27 MSTRG.26284.2_1 - 9.6e-15 54.9 0.1 2.5e-14 53.5 0.1 1.8 1 0 0 1 1 1 1 PH domain Pkinase_C PF00433.22 MSTRG.26284.2_1 - 9.3e-09 35.7 3.6 9.3e-09 35.7 3.6 1.9 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.4 MSTRG.26284.2_1 - 5.5e-06 25.8 0.0 1e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.4 MSTRG.26284.2_1 - 0.039 13.4 0.3 5.3 6.5 0.1 2.2 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Yae1_N PF09811.7 MSTRG.26284.2_3 - 2.2 8.0 6.4 4.6 6.9 6.4 1.5 1 0 0 1 1 1 0 Essential protein Yae1, N terminal Mito_carr PF00153.25 MSTRG.19875.1_2 - 4e-62 206.0 0.2 5.7e-26 90.1 0.0 3.6 3 0 0 3 3 3 3 Mitochondrial carrier protein Exo_endo_phos PF03372.21 MSTRG.26557.1_2 - 1.1e-10 41.6 0.0 1.8e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SLR1-BP PF07333.10 MSTRG.26557.1_3 - 1.9 8.9 7.5 4.1 7.8 0.9 2.9 2 0 0 2 2 2 0 S locus-related glycoprotein 1 binding pollen coat protein (SLR1-BP) Ribosomal_L14 PF00238.17 MSTRG.24154.4_1 - 4.7e-34 116.9 0.2 6.1e-34 116.6 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e zf-H2C2_2 PF13465.4 MSTRG.16098.1_3 - 2e-53 176.4 46.6 1.3e-09 37.9 0.4 8.1 8 0 0 8 8 8 7 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.16098.1_3 - 8.9e-35 117.1 52.5 2.9e-05 24.1 0.5 8.2 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.16098.1_3 - 7.4e-25 85.3 58.3 0.00024 21.5 0.4 8.3 8 0 0 8 8 7 7 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.16098.1_3 - 5.6e-14 51.5 37.3 0.0003 20.5 0.2 7.8 7 0 0 7 7 7 6 C2H2-type zinc finger zf-Di19 PF05605.10 MSTRG.16098.1_3 - 2.2e-09 37.3 25.9 0.00049 20.2 1.8 5.0 1 1 4 6 6 6 5 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.6 MSTRG.16098.1_3 - 1.3e-06 28.4 19.5 0.53 10.5 0.2 7.2 7 0 0 7 7 7 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.16098.1_3 - 1.6e-06 28.2 42.0 0.031 14.5 0.2 7.3 7 0 0 7 7 7 4 Zinc-finger of C2H2 type LIM PF00412.20 MSTRG.16098.1_3 - 5.6e-05 23.1 22.3 2.9 8.1 1.7 6.7 2 1 4 6 6 6 1 LIM domain Zn-ribbon_8 PF09723.8 MSTRG.16098.1_3 - 0.00016 21.6 17.5 0.019 15.0 0.9 5.2 4 2 1 5 5 5 2 Zinc ribbon domain zf-C2H2_11 PF16622.3 MSTRG.16098.1_3 - 0.00024 20.7 35.4 0.15 11.7 0.4 7.8 8 0 0 8 8 8 3 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 MSTRG.16098.1_3 - 0.0011 19.6 16.6 2.2 8.9 0.5 4.5 1 1 2 4 4 4 3 zinc-ribbon family zf-H2C2_5 PF13909.4 MSTRG.16098.1_3 - 0.0013 18.3 41.5 0.071 12.8 1.4 7.6 6 1 1 7 7 7 4 C2H2-type zinc-finger domain CpXC PF14353.4 MSTRG.16098.1_3 - 0.0071 16.2 17.3 1.3 8.9 0.3 6.1 3 2 3 6 6 6 1 CpXC protein BolA PF01722.16 MSTRG.16098.1_3 - 0.0096 16.1 10.5 2.4 8.4 0.7 4.8 2 2 1 3 3 3 1 BolA-like protein zf-C2H2_2 PF12756.5 MSTRG.16098.1_3 - 0.043 14.0 26.6 3.5 7.9 0.4 6.4 1 1 5 6 6 6 0 C2H2 type zinc-finger (2 copies) Rad50_zn_hook PF04423.12 MSTRG.16098.1_3 - 0.055 13.2 3.9 0.85 9.4 0.1 3.3 3 0 0 3 3 3 0 Rad50 zinc hook motif Yippee-Mis18 PF03226.12 MSTRG.16098.1_3 - 0.064 13.3 14.7 1.6 8.8 0.0 3.6 2 1 0 3 3 3 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-C2HE PF16278.3 MSTRG.16098.1_3 - 0.082 13.2 40.9 0.29 11.5 0.6 7.9 2 1 6 8 8 8 0 C2HE / C2H2 / C2HC zinc-binding finger zf-LYAR PF08790.9 MSTRG.16098.1_3 - 0.12 12.2 22.2 11 5.9 0.3 7.3 7 0 0 7 7 7 0 LYAR-type C2HC zinc finger zf-C2H2_9 PF16293.3 MSTRG.16098.1_3 - 0.13 12.0 8.9 14 5.5 0.0 4.9 6 0 0 6 6 6 0 C2H2 type zinc-finger (1 copy) Elf1 PF05129.11 MSTRG.16098.1_3 - 0.19 11.6 33.3 0.11 12.5 1.7 5.6 2 1 5 7 7 7 0 Transcription elongation factor Elf1 like DUF3268 PF11672.6 MSTRG.16098.1_3 - 4.6 7.5 11.2 12 6.2 0.2 3.7 1 1 0 4 4 4 0 zinc-finger-containing domain GAGA PF09237.9 MSTRG.16098.1_3 - 7 6.4 11.3 2.3 8.0 0.3 4.3 2 1 4 6 6 6 0 GAGA factor zf-AN1 PF01428.14 MSTRG.16098.1_3 - 7.5 6.7 28.6 34 4.6 2.1 6.8 6 1 1 7 7 7 0 AN1-like Zinc finger PAX PF00292.16 MSTRG.26241.1_1 - 1.9e-74 247.4 0.6 3e-74 246.8 0.6 1.3 1 0 0 1 1 1 1 'Paired box' domain Pax2_C PF12403.6 MSTRG.26241.1_1 - 2.5e-51 172.4 16.3 4.6e-51 171.6 16.3 1.3 1 0 0 1 1 1 1 Paired-box protein 2 C terminal HTH_32 PF13565.4 MSTRG.26241.1_1 - 0.00029 21.3 0.1 0.072 13.6 0.0 2.8 1 1 1 2 2 2 2 Homeodomain-like domain HTH_23 PF13384.4 MSTRG.26241.1_1 - 0.00057 19.5 0.0 0.0011 18.5 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.4 MSTRG.26241.1_1 - 0.085 12.9 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain SCAMP PF04144.11 MSTRG.23662.1_3 - 4e-08 33.6 1.9 6.9e-08 32.9 1.9 1.4 1 0 0 1 1 1 1 SCAMP family V-set PF07686.15 MSTRG.19230.3_1 - 8e-07 29.1 0.5 1.1e-05 25.3 0.0 2.7 3 0 0 3 3 3 1 Immunoglobulin V-set domain Ig_2 PF13895.4 MSTRG.19230.3_1 - 0.00063 19.9 0.1 0.0077 16.4 0.0 2.8 2 1 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.19230.3_1 - 0.0014 19.0 0.0 0.036 14.5 0.0 2.6 1 1 1 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.10 MSTRG.19230.3_1 - 0.0078 16.1 0.0 0.02 14.8 0.0 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain V-set PF07686.15 MSTRG.19230.3_3 - 5.1e-08 32.9 0.0 8.6e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Izumo-Ig PF16706.3 MSTRG.19230.3_3 - 0.0063 16.4 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 Izumo-like Immunoglobulin domain I-set PF07679.14 MSTRG.19230.3_3 - 0.012 15.5 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain BAG PF02179.14 MSTRG.14740.2_1 - 1.4e-18 66.9 4.7 2.5e-18 66.1 4.7 1.4 1 0 0 1 1 1 1 BAG domain WW PF00397.24 MSTRG.14740.2_1 - 1e-09 38.0 1.1 2.5e-09 36.8 1.1 1.7 1 0 0 1 1 1 1 WW domain MANEC PF07502.12 MSTRG.24202.1_2 - 7.1e-13 48.5 2.7 1.3e-12 47.7 2.7 1.3 1 0 0 1 1 1 1 MANEC domain Plexin_cytopl PF08337.10 MSTRG.18274.1_2 - 5.5e-57 193.5 0.3 6.2e-57 193.4 0.3 1.0 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Filamin PF00630.17 MSTRG.12971.3_3 - 4.4e-47 159.0 0.6 7.2e-12 45.9 0.0 4.3 4 0 0 4 4 4 4 Filamin/ABP280 repeat Myco_19_kDa PF05481.10 MSTRG.12971.3_3 - 0.0046 16.8 0.4 0.0046 16.8 0.4 2.1 2 0 0 2 2 2 1 Mycobacterium 19 kDa lipoprotein antigen Y_Y_Y PF07495.11 MSTRG.12971.3_3 - 0.048 13.5 0.1 6.8 6.6 0.1 2.9 3 0 0 3 3 3 0 Y_Y_Y domain Ribosomal_L16 PF00252.16 MSTRG.11348.2_2 - 2.7e-30 105.0 0.5 3.8e-30 104.5 0.5 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Kringle PF00051.16 MSTRG.2321.1_3 - 3e-24 85.0 4.0 1e-23 83.3 4.0 2.0 1 0 0 1 1 1 1 Kringle domain Fz PF01392.20 MSTRG.2321.1_3 - 2.3e-12 47.5 2.3 6e-12 46.1 2.3 1.7 1 0 0 1 1 1 1 Fz domain TMEM154 PF15102.4 MSTRG.2321.1_3 - 0.089 12.6 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 TMEM154 protein family PID_2 PF14719.4 MSTRG.17101.1_2 - 2.3e-14 53.5 0.0 4.2e-14 52.7 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PID PF00640.21 MSTRG.17101.1_2 - 9.6e-06 25.6 0.2 1.7e-05 24.7 0.2 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Spectrin PF00435.19 MSTRG.21197.1_2 - 5.6e-12 45.9 0.5 5.6e-12 45.9 0.5 2.4 2 1 1 3 3 3 1 Spectrin repeat dsrm PF00035.24 MSTRG.23105.1_3 - 3.1e-45 152.6 0.9 1.4e-10 41.6 0.0 5.2 6 0 0 6 6 6 4 Double-stranded RNA binding motif Staufen_C PF16482.3 MSTRG.23105.1_3 - 1.4e-44 150.7 1.4 2.8e-43 146.5 0.1 3.3 4 0 0 4 4 4 1 Staufen C-terminal domain DND1_DSRM PF14709.5 MSTRG.23105.1_3 - 2.5e-07 30.7 1.4 0.43 10.7 0.1 4.8 4 3 0 4 4 4 3 double strand RNA binding domain from DEAD END PROTEIN 1 LPP20 PF02169.14 MSTRG.23105.1_3 - 1.7 8.9 5.3 25 5.2 0.1 3.4 2 1 1 3 3 3 0 LPP20 lipoprotein Tubulin-binding PF00418.17 MSTRG.22896.1_2 - 5.4e-12 45.4 0.0 8.3e-12 44.8 0.0 1.3 1 0 0 1 1 1 1 Tau and MAP protein, tubulin-binding repeat DUF4222 PF13973.4 MSTRG.5759.1_1 - 0.064 12.7 0.1 0.087 12.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4222) Histone_H2A_C PF16211.3 MSTRG.5759.1_1 - 0.098 12.3 0.2 0.15 11.7 0.2 1.2 1 0 0 1 1 1 0 C-terminus of histone H2A WD40 PF00400.30 MSTRG.9643.1_2 - 1.3e-36 123.8 11.5 1e-06 29.2 0.0 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.9643.1_2 - 2.1e-14 53.5 0.6 0.00066 19.8 0.1 5.1 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.4 MSTRG.9643.1_2 - 0.029 13.8 0.0 0.06 12.8 0.0 1.5 1 0 0 1 1 1 0 PQQ-like domain Pkinase PF00069.23 MSTRG.23725.1_2 - 5e-05 22.6 0.0 0.00018 20.9 0.0 1.8 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.23725.1_2 - 0.054 12.6 0.0 0.085 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase TRC8_N PF13705.4 MSTRG.19900.1_1 - 2.2e-130 435.8 46.2 2.2e-130 435.8 46.2 1.8 2 0 0 2 2 2 1 TRC8 N-terminal domain zf-RING_2 PF13639.4 MSTRG.19900.1_1 - 7.5e-09 35.6 8.6 7.5e-09 35.6 8.6 2.6 2 1 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 MSTRG.19900.1_1 - 1.7e-07 30.8 8.1 1.7e-07 30.8 8.1 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 MSTRG.19900.1_1 - 2.4e-07 30.8 8.6 2.4e-07 30.8 8.6 2.0 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.4 MSTRG.19900.1_1 - 9.3e-07 28.6 2.5 2.5e-06 27.3 2.5 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 MSTRG.19900.1_1 - 3.7e-06 26.6 7.1 3.7e-06 26.6 7.1 2.9 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 MSTRG.19900.1_1 - 8.5e-06 25.4 5.8 8.5e-06 25.4 5.8 2.9 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 MSTRG.19900.1_1 - 1.3e-05 24.8 6.9 1.3e-05 24.8 6.9 2.0 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.5 MSTRG.19900.1_1 - 4e-05 23.5 6.7 4e-05 23.5 6.7 2.7 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.4 MSTRG.19900.1_1 - 0.00025 20.8 7.3 0.00025 20.8 7.3 2.5 2 1 1 3 3 1 1 zinc-RING finger domain zf-RING_11 PF17123.3 MSTRG.19900.1_1 - 0.0018 17.8 5.3 0.0059 16.2 5.3 2.0 1 0 0 1 1 1 1 RING-like zinc finger zf-P11 PF03854.12 MSTRG.19900.1_1 - 0.037 13.6 4.9 0.14 11.7 4.9 2.0 1 0 0 1 1 1 0 P-11 zinc finger Exo_endo_phos PF03372.21 MSTRG.5986.1_3 - 3.5e-15 56.1 0.0 4.9e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Guanylate_kin PF00625.19 MSTRG.20416.1_1 - 4.2e-44 150.3 0.0 1.1e-43 148.9 0.0 1.6 1 1 0 1 1 1 1 Guanylate kinase PDZ PF00595.22 MSTRG.20416.1_1 - 3e-12 46.6 0.4 5.9e-12 45.6 0.4 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) SH3_2 PF07653.15 MSTRG.20416.1_1 - 2.4e-05 23.8 0.0 7.1e-05 22.3 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.20416.1_1 - 0.00022 20.6 1.9 0.0003 20.2 0.1 2.3 2 1 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 MSTRG.20416.1_1 - 0.0017 18.0 0.4 0.015 15.0 0.0 2.5 2 0 0 2 2 2 1 Variant SH3 domain PDZ_2 PF13180.4 MSTRG.20416.1_1 - 0.0019 18.4 0.3 0.0049 17.0 0.1 1.8 2 0 0 2 2 2 1 PDZ domain FXMRP1_C_core PF12235.6 MSTRG.15927.1_2 - 1.1e-41 142.5 5.7 1.1e-41 142.5 5.7 2.7 1 1 2 3 3 3 1 Fragile X-related 1 protein core C terminal FXMR_C2 PF16098.3 MSTRG.15927.1_2 - 9.4e-24 83.6 5.9 8.1e-23 80.6 5.9 2.5 1 1 0 1 1 1 1 Fragile X-related mental retardation protein C-terminal region 2 Agenet PF05641.10 MSTRG.15927.1_2 - 9.6e-14 51.5 1.4 1.7e-08 34.7 0.1 2.9 3 0 0 3 3 3 2 Agenet domain KH_1 PF00013.27 MSTRG.15927.1_2 - 2e-13 49.8 0.1 7.4e-07 28.8 0.1 2.7 2 0 0 2 2 2 2 KH domain KH_4 PF13083.4 MSTRG.15927.1_2 - 0.13 12.0 0.1 3.9 7.3 0.1 2.7 2 0 0 2 2 2 0 KH domain CENP-F_leu_zip PF10473.7 MSTRG.18836.1_3 - 0.0076 16.2 0.5 0.012 15.5 0.5 1.1 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.4 MSTRG.18836.1_3 - 0.017 14.4 1.8 0.022 14.0 1.8 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding zf-H2C2_2 PF13465.4 MSTRG.20085.1_2 - 1.1e-37 126.7 93.2 4.9e-10 39.3 1.6 11.5 11 0 0 11 11 11 6 Zinc-finger double domain zf-H2C2_5 PF13909.4 MSTRG.20085.1_2 - 4.1e-29 99.9 78.9 4.9e-08 32.4 5.8 8.6 8 0 0 8 8 8 8 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 MSTRG.20085.1_2 - 1.9e-18 65.7 93.8 0.0033 17.7 5.1 10.1 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.20085.1_2 - 0.00043 20.7 91.8 0.14 12.9 3.5 10.8 10 0 0 10 10 10 7 C2H2-type zinc finger DUF4688 PF15752.3 MSTRG.20085.1_2 - 0.14 11.2 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4688) GAGA PF09237.9 MSTRG.20085.1_2 - 1.5 8.6 34.4 0.089 12.5 0.4 6.8 2 2 5 7 7 7 0 GAGA factor F5_F8_type_C PF00754.23 MSTRG.23687.1_1 - 0.00076 19.5 0.0 0.0012 18.8 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain UPF0240 PF06784.9 MSTRG.2778.1_3 - 3.9e-24 85.5 0.3 4.2e-24 85.4 0.3 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0240) Serpin PF00079.18 MSTRG.17779.1_1 - 2.7e-93 313.1 1.5 3.3e-93 312.8 1.5 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Thioredoxin PF00085.18 MSTRG.10766.1_3 - 3.4e-83 274.2 1.8 4.6e-29 100.3 0.0 3.3 3 0 0 3 3 3 3 Thioredoxin Thioredoxin_2 PF13098.4 MSTRG.10766.1_3 - 1.8e-18 66.9 2.0 5.8e-05 23.4 0.2 3.7 3 0 0 3 3 3 3 Thioredoxin-like domain OST3_OST6 PF04756.11 MSTRG.10766.1_3 - 7.3e-11 41.8 1.0 0.0015 17.8 0.1 3.3 3 0 0 3 3 3 3 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.4 MSTRG.10766.1_3 - 4.8e-09 36.3 2.8 0.06 13.5 0.2 5.3 3 3 2 5 5 5 3 Thioredoxin-like Thioredoxin_6 PF13848.4 MSTRG.10766.1_3 - 1.1e-07 31.9 0.4 0.087 12.6 0.0 3.9 4 0 0 4 4 4 2 Thioredoxin-like domain Thioredoxin_7 PF13899.4 MSTRG.10766.1_3 - 1.9e-06 27.8 3.2 0.067 13.3 0.1 3.9 3 0 0 3 3 3 2 Thioredoxin-like Thioredoxin_9 PF14595.4 MSTRG.10766.1_3 - 4.8e-06 26.3 0.9 0.84 9.3 0.1 3.3 3 0 0 3 3 3 3 Thioredoxin HyaE PF07449.9 MSTRG.10766.1_3 - 9.8e-05 22.1 0.0 0.048 13.5 0.0 2.8 3 0 0 3 3 3 1 Hydrogenase-1 expression protein HyaE AhpC-TSA PF00578.19 MSTRG.10766.1_3 - 0.00094 19.0 1.2 2.6 7.8 0.0 3.3 3 0 0 3 3 3 2 AhpC/TSA family TraF PF13728.4 MSTRG.10766.1_3 - 0.0037 17.0 14.9 0.078 12.7 0.0 4.2 3 1 1 4 4 3 2 F plasmid transfer operon protein Peptidase_C25 PF01364.16 MSTRG.10766.1_3 - 0.023 13.8 0.0 3.1 6.7 0.0 2.2 2 0 0 2 2 2 0 Peptidase family C25 Thioredoxin_3 PF13192.4 MSTRG.10766.1_3 - 0.05 13.5 2.6 4.6 7.2 0.0 3.6 4 0 0 4 4 4 0 Thioredoxin domain CDC45 PF02724.12 MSTRG.10766.1_3 - 6.9 4.7 7.2 10 4.1 7.2 1.2 1 0 0 1 1 1 0 CDC45-like protein Rad60-SLD PF11976.6 MSTRG.5322.1_3 - 1.8e-11 43.6 0.0 8e-07 28.7 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.21 MSTRG.5322.1_3 - 1.6e-05 24.4 0.0 0.13 11.9 0.0 2.5 2 0 0 2 2 2 2 Ubiquitin family adh_short PF00106.23 MSTRG.4979.1_1 - 5.1e-25 87.9 0.0 1.2e-24 86.7 0.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 MSTRG.4979.1_1 - 7.5e-17 61.5 0.0 1.1e-16 60.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 MSTRG.4979.1_1 - 1.3e-06 28.3 0.2 2.2e-06 27.6 0.2 1.3 1 0 0 1 1 1 1 KR domain Glyco_trans_4_4 PF13579.4 MSTRG.4979.1_1 - 0.00025 21.4 0.3 0.00025 21.4 0.3 2.0 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Epimerase PF01370.19 MSTRG.4979.1_1 - 0.004 16.5 0.0 0.0059 16.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family AdoHcyase_NAD PF00670.19 MSTRG.4979.1_1 - 0.069 13.1 0.6 0.12 12.3 0.6 1.2 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain THF_DHG_CYH_C PF02882.17 MSTRG.4979.1_1 - 0.083 12.1 0.1 0.15 11.2 0.1 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Eno-Rase_NADH_b PF12242.6 MSTRG.4979.1_1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Shikimate_DH PF01488.18 MSTRG.4979.1_1 - 0.16 11.9 0.2 0.27 11.2 0.2 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ELL PF10390.7 MSTRG.29400.1_2 - 0.0012 18.3 0.0 0.0015 17.9 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase II elongation factor ELL Collagen PF01391.16 MSTRG.19253.1_1 - 4.9e-17 61.3 97.3 1.6e-07 30.9 47.2 3.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) CD34_antigen PF06365.10 MSTRG.5103.1_1 - 2.4e-25 89.3 1.0 3e-25 88.9 0.0 1.6 2 0 0 2 2 2 1 CD34/Podocalyxin family TNFR_c6 PF00020.16 MSTRG.15555.1_3 - 3.3e-17 62.5 81.0 1.2e-08 35.1 8.6 6.0 6 0 0 6 6 6 4 TNFR/NGFR cysteine-rich region Death PF00531.20 MSTRG.15555.1_3 - 1.4e-11 44.3 0.0 2.5e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 Death domain AA_permease PF00324.19 MSTRG.3875.1_2 - 1.7e-94 317.0 45.7 2.1e-94 316.7 45.7 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.13 MSTRG.3875.1_2 - 2.8e-22 79.2 0.9 3e-10 39.6 0.0 3.3 2 1 0 3 3 3 3 Solute carrier family 12 RRM_5 PF13893.4 MSTRG.19847.5_1 - 4.4e-53 178.0 2.8 1e-38 131.6 0.0 3.9 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.20 MSTRG.19847.5_1 - 1.5e-28 98.3 2.6 2.2e-08 33.7 0.1 4.7 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 MSTRG.19847.5_1 - 3.1e-06 26.8 0.2 0.14 11.9 0.0 4.0 4 0 0 4 4 4 2 Occluded RNA-recognition motif MCM PF00493.21 MSTRG.25648.1_1 - 2.4e-127 424.5 0.6 5.5e-127 423.3 0.6 1.5 1 0 0 1 1 1 1 MCM2/3/5 family MCM_OB PF17207.1 MSTRG.25648.1_1 - 1.3e-34 118.6 0.1 3e-34 117.5 0.1 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_N PF14551.4 MSTRG.25648.1_1 - 8.9e-11 42.2 0.5 3.3e-10 40.4 0.5 2.0 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.19 MSTRG.25648.1_1 - 1.6e-07 30.8 0.0 8.2e-07 28.5 0.0 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.9 MSTRG.25648.1_1 - 0.0016 18.2 0.1 0.0067 16.2 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.12 MSTRG.25648.1_1 - 0.002 18.0 0.0 0.005 16.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.24 MSTRG.25648.1_1 - 0.05 13.2 0.0 0.14 11.7 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_16 PF13191.4 MSTRG.25648.1_1 - 0.36 11.0 1.6 1 9.6 0.1 2.5 2 1 0 2 2 2 0 AAA ATPase domain DTHCT PF08070.9 MSTRG.25648.1_1 - 4.2 8.0 13.5 12 6.5 4.7 2.3 1 1 1 2 2 2 0 DTHCT (NUC029) region DnaJ PF00226.29 MSTRG.19814.2_3 - 5.7e-19 67.9 0.0 1.2e-18 66.8 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain Ly49 PF08391.8 MSTRG.19814.2_3 - 1.1 9.4 5.5 0.35 11.1 0.4 2.1 1 1 1 2 2 2 0 Ly49-like protein, N-terminal region PDZ PF00595.22 MSTRG.16366.1_2 - 1.9e-11 44.0 0.0 2.6e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.16366.1_2 - 2e-07 31.1 0.0 3.3e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 PDZ domain TACI-CRD2 PF09305.8 MSTRG.13191.1_1 - 0.03 14.2 1.8 0.098 12.6 1.4 2.1 1 1 0 1 1 1 0 TACI, cysteine-rich domain Tyr_Deacylase PF02580.14 MSTRG.13191.1_2 - 6.6e-48 162.8 0.0 1e-47 162.1 0.0 1.3 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Piwi PF02171.15 MSTRG.2935.2_2 - 7.7e-105 350.3 0.8 1.2e-104 349.7 0.4 1.5 2 0 0 2 2 2 1 Piwi domain PAZ PF02170.20 MSTRG.2935.2_2 - 1.7e-31 108.7 0.0 3.4e-31 107.8 0.0 1.4 1 0 0 1 1 1 1 PAZ domain ArgoN PF16486.3 MSTRG.2935.2_2 - 0.00028 21.5 0.0 0.00073 20.1 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.8 MSTRG.2935.2_2 - 0.0013 18.2 0.0 0.0031 17.0 0.0 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.3 MSTRG.2935.2_2 - 0.021 15.0 0.0 0.12 12.6 0.0 2.3 2 0 0 2 2 2 0 Argonaute linker 2 domain FBA PF04300.11 MSTRG.25494.1_2 - 7.8e-50 169.1 0.0 1e-49 168.7 0.0 1.1 1 0 0 1 1 1 1 F-box associated region MRP-S32 PF10210.7 MSTRG.11705.1_2 - 1.4e-34 118.4 0.4 2.2e-34 117.7 0.4 1.3 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S32 Nuc_deoxyrib_tr PF05014.13 MSTRG.11705.1_2 - 0.13 12.2 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Nucleoside 2-deoxyribosyltransferase Alg6_Alg8 PF03155.13 MSTRG.3913.1_3 - 6.7e-166 552.8 23.9 7.9e-166 552.5 23.9 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family ArfGap PF01412.16 MSTRG.17104.1_1 - 5.2e-29 100.5 0.0 9.1e-29 99.7 0.0 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Pkinase PF00069.23 MSTRG.13815.2_3 - 1.2e-49 168.9 0.0 2.3e-49 168.0 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.13815.2_3 - 2.2e-23 82.7 0.0 3.5e-23 82.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 MSTRG.13815.2_3 - 0.00025 20.3 0.0 0.00043 19.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 MSTRG.13815.2_3 - 0.039 13.7 0.0 0.073 12.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Nup96 PF12110.6 MSTRG.13815.2_3 - 0.041 12.8 0.1 0.096 11.6 0.1 1.5 1 0 0 1 1 1 0 Nuclear protein 96 GTP_EFTU PF00009.25 MSTRG.13313.4_1 - 1.1e-51 175.1 0.0 1.4e-51 174.7 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.23 MSTRG.13313.4_1 - 3.7e-09 36.7 0.1 1.7e-08 34.6 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 MSTRG.13313.4_1 - 9.4e-07 28.8 0.1 0.00011 22.2 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.4 MSTRG.13313.4_1 - 0.00016 21.5 0.1 0.0045 16.8 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 4 G-alpha PF00503.18 MSTRG.13313.4_1 - 0.07 12.1 0.0 0.16 10.9 0.0 1.5 1 1 1 2 2 2 0 G-protein alpha subunit Gtr1_RagA PF04670.10 MSTRG.13313.4_1 - 0.072 12.3 0.0 0.2 10.9 0.0 1.9 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region FAM27 PF15832.3 MSTRG.8565.1_1 - 5.5 7.5 33.2 1.2 9.6 16.8 2.2 2 0 0 2 2 2 0 FAM27 D and E protein family FAM27 PF15832.3 MSTRG.8565.1_3 - 0.02 15.3 22.5 0.025 14.9 9.4 2.5 2 0 0 2 2 2 0 FAM27 D and E protein family DUF4808 PF16066.3 MSTRG.8565.1_3 - 0.084 13.4 1.0 0.12 12.9 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4808) dCMP_cyt_deam_1 PF00383.21 MSTRG.13250.1_3 - 3.5e-28 97.3 0.1 5e-28 96.8 0.1 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.4 MSTRG.13250.1_3 - 4.8e-15 55.4 0.0 6.5e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase Y_phosphatase PF00102.25 MSTRG.22127.1_3 - 5.9e-14 52.1 0.5 9.4e-14 51.4 0.5 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase SRP9-21 PF05486.10 MSTRG.16492.1_2 - 7.3e-12 45.4 0.2 5.4e-11 42.6 0.2 2.1 1 1 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) EHN PF06441.10 MSTRG.16492.1_3 - 2.2e-34 117.8 0.2 3.9e-34 117.0 0.2 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.18 MSTRG.16492.1_3 - 3e-18 66.3 0.0 5.2e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 MSTRG.16492.1_3 - 0.092 13.2 0.0 0.17 12.4 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family ZZ PF00569.15 MSTRG.22800.1_1 - 3.6e-17 61.8 15.8 1.5e-08 34.2 5.4 3.5 2 0 0 2 2 2 2 Zinc finger, ZZ type SURF2 PF05477.9 MSTRG.13139.1_1 - 1e-87 293.4 15.0 1.2e-87 293.1 15.0 1.0 1 0 0 1 1 1 1 Surfeit locus protein 2 (SURF2) Pyr_redox_2 PF07992.12 MSTRG.7285.1_1 - 8.1e-65 218.8 0.7 1.2e-64 218.2 0.7 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.20 MSTRG.7285.1_1 - 1.1e-34 118.8 0.8 2.2e-34 117.9 0.8 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.25 MSTRG.7285.1_1 - 1.3e-18 67.2 4.6 4.2e-18 65.5 0.2 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 MSTRG.7285.1_1 - 3.7e-17 62.4 0.2 6e-17 61.7 0.2 1.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.5 MSTRG.7285.1_1 - 4e-05 23.0 0.2 9.9e-05 21.7 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase DAO PF01266.22 MSTRG.7285.1_1 - 0.00019 21.0 0.3 0.098 12.1 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.22 MSTRG.7285.1_1 - 0.00072 18.6 8.1 0.016 14.1 3.2 2.5 2 0 0 2 2 2 2 FAD binding domain GIDA PF01134.20 MSTRG.7285.1_1 - 0.0022 17.0 6.0 0.18 10.8 4.3 2.5 2 1 0 2 2 2 2 Glucose inhibited division protein A AlaDh_PNT_C PF01262.19 MSTRG.7285.1_1 - 0.0026 17.0 1.3 0.17 11.1 0.3 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.12 MSTRG.7285.1_1 - 0.012 14.2 2.8 0.16 10.5 1.1 2.7 3 0 0 3 3 3 0 HI0933-like protein Thi4 PF01946.15 MSTRG.7285.1_1 - 0.032 13.3 0.1 0.073 12.2 0.1 1.5 1 0 0 1 1 1 0 Thi4 family NAD_binding_7 PF13241.4 MSTRG.7285.1_1 - 0.1 12.9 0.2 6.9 7.0 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding NAD_binding_8 PF13450.4 MSTRG.7285.1_1 - 0.43 10.7 4.9 0.063 13.4 0.8 1.7 2 0 0 2 2 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.17 MSTRG.7285.1_1 - 3.8 6.5 8.2 5.7 6.0 0.5 2.6 3 0 0 3 3 3 0 FAD binding domain UBA_5 PF16577.3 MSTRG.25799.2_3 - 3.5e-37 126.2 0.1 6.3e-37 125.4 0.1 1.4 1 0 0 1 1 1 1 UBA domain ZZ PF00569.15 MSTRG.25799.2_3 - 1.1e-12 47.4 2.9 2.6e-12 46.2 2.9 1.7 1 0 0 1 1 1 1 Zinc finger, ZZ type PB1 PF00564.22 MSTRG.25799.2_3 - 3.5e-06 26.7 0.1 7e-06 25.7 0.1 1.5 1 0 0 1 1 1 1 PB1 domain C1_2 PF03107.14 MSTRG.25799.2_3 - 0.0011 19.1 3.7 0.0045 17.2 3.7 2.1 1 0 0 1 1 1 1 C1 domain zf-H2C2_2 PF13465.4 MSTRG.21342.1_3 - 2e-47 157.5 53.3 7.8e-10 38.6 0.5 8.7 8 1 0 8 8 8 7 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.21342.1_3 - 6.3e-37 123.9 53.9 3.2e-06 27.2 0.9 7.5 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.21342.1_3 - 9e-31 103.8 49.7 8.8e-05 22.9 1.0 7.5 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.21342.1_3 - 1.1e-22 79.3 46.0 0.00038 20.2 0.5 7.8 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.21342.1_3 - 1.5e-12 47.4 29.3 0.18 12.1 0.6 7.4 6 1 1 7 7 7 6 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.21342.1_3 - 8.8e-12 44.9 49.0 0.011 15.9 1.4 7.5 7 0 0 7 7 7 6 Zinc-finger of C2H2 type BolA PF01722.16 MSTRG.21342.1_3 - 1.8e-07 31.2 10.6 0.44 10.7 2.5 5.4 1 1 3 4 4 4 3 BolA-like protein zf-Di19 PF05605.10 MSTRG.21342.1_3 - 7.4e-07 29.2 34.6 3.9e-05 23.7 2.8 5.4 1 1 6 7 7 7 5 Drought induced 19 protein (Di19), zinc-binding LIM PF00412.20 MSTRG.21342.1_3 - 1.4e-05 25.1 32.4 0.18 11.9 3.0 6.6 1 1 3 6 6 6 3 LIM domain zf-LYAR PF08790.9 MSTRG.21342.1_3 - 0.00021 21.0 30.6 2.2 8.2 0.1 7.6 7 0 0 7 7 7 3 LYAR-type C2HC zinc finger DUF2256 PF10013.7 MSTRG.21342.1_3 - 0.0015 18.4 23.8 6.7 6.8 0.1 7.0 7 0 0 7 7 7 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2H2_2 PF12756.5 MSTRG.21342.1_3 - 0.0064 16.7 34.7 1.4 9.1 0.1 6.9 1 1 6 7 7 7 3 C2H2 type zinc-finger (2 copies) DUF3268 PF11672.6 MSTRG.21342.1_3 - 0.056 13.7 12.2 6.4 7.0 0.1 3.7 3 1 1 4 4 4 0 zinc-finger-containing domain Rad50_zn_hook PF04423.12 MSTRG.21342.1_3 - 0.15 11.8 0.1 0.15 11.8 0.1 4.8 6 0 0 6 6 5 0 Rad50 zinc hook motif zinc_ribbon_15 PF17032.3 MSTRG.21342.1_3 - 0.35 11.5 28.7 0.81 10.3 1.0 4.4 1 1 6 7 7 7 0 zinc-ribbon family DUF2180 PF09947.7 MSTRG.21342.1_3 - 0.41 10.5 15.7 4.3 7.3 0.0 4.7 1 1 3 5 5 5 0 Uncharacterized protein conserved in archaea (DUF2180) Zn-ribbon_8 PF09723.8 MSTRG.21342.1_3 - 0.43 10.6 30.9 0.42 10.6 1.3 6.0 3 3 3 6 6 6 0 Zinc ribbon domain zf-BED PF02892.13 MSTRG.21342.1_3 - 0.5 10.3 46.8 7.1 6.6 1.9 7.6 1 1 6 7 7 7 0 BED zinc finger zf-C2HC_2 PF13913.4 MSTRG.21342.1_3 - 1 9.2 32.1 0.82 9.5 0.2 7.1 7 0 0 7 7 7 0 zinc-finger of a C2HC-type GAGA PF09237.9 MSTRG.21342.1_3 - 1.4 8.7 9.3 10 5.9 0.1 4.2 2 1 2 4 4 4 0 GAGA factor zf-RRN7 PF11781.6 MSTRG.21342.1_3 - 2 8.0 16.2 9.6 5.9 0.2 5.5 5 0 0 5 5 5 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 CpXC PF14353.4 MSTRG.21342.1_3 - 2.3 8.2 20.8 5.8 6.8 1.1 6.2 3 2 1 5 5 5 0 CpXC protein zf-C2H2_9 PF16293.3 MSTRG.21342.1_3 - 4.2 7.1 10.6 9.1 6.1 0.0 4.6 6 0 0 6 6 6 0 C2H2 type zinc-finger (1 copy) ADK_lid PF05191.12 MSTRG.21342.1_3 - 4.8 7.2 21.9 5.7 6.9 1.2 5.7 3 2 4 7 7 7 0 Adenylate kinase, active site lid zf-C4_ClpX PF06689.11 MSTRG.21342.1_3 - 6.9 6.5 33.8 0.2 11.4 2.5 6.9 6 1 0 6 6 6 0 ClpX C4-type zinc finger BTB PF00651.29 MSTRG.28562.1_1 - 7.6e-15 55.0 0.3 1e-14 54.6 0.3 1.2 1 0 0 1 1 1 1 BTB/POZ domain 7tm_1 PF00001.19 MSTRG.1143.1_1 - 7.4e-45 153.1 14.8 9.4e-45 152.8 14.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 MSTRG.1143.1_1 - 0.5 9.5 11.8 0.08 12.1 7.2 1.9 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx AKAP95 PF04988.10 MSTRG.27700.1_2 - 9.5e-67 224.2 9.5 1.9e-66 223.2 9.5 1.5 1 0 0 1 1 1 1 A-kinase anchoring protein 95 (AKAP95) zf-H2C2_5 PF13909.4 MSTRG.27700.1_2 - 0.05 13.2 0.6 0.16 11.6 0.6 1.9 1 0 0 1 1 1 0 C2H2-type zinc-finger domain Actin_micro PF17003.3 MSTRG.27700.1_2 - 0.05 12.6 12.1 64 2.4 12.1 2.2 1 1 0 1 1 1 0 Putative actin-like family BUD22 PF09073.8 MSTRG.27700.1_2 - 5.5 6.1 35.3 0.34 10.1 19.9 2.1 2 0 0 2 2 2 0 BUD22 Ig_3 PF13927.4 MSTRG.25520.1_1 - 5.6e-18 65.2 0.8 3e-11 43.7 0.1 2.8 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 MSTRG.25520.1_1 - 1.4e-14 53.8 0.1 3.2e-09 36.6 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 MSTRG.25520.1_1 - 7.6e-10 38.7 0.1 1.5e-05 24.9 0.0 3.0 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 MSTRG.25520.1_1 - 6.1e-09 35.9 0.0 0.004 17.2 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_2 PF13895.4 MSTRG.25520.1_1 - 7.6e-09 35.7 0.1 2e-07 31.1 0.1 2.6 2 0 0 2 2 2 1 Immunoglobulin domain Izumo-Ig PF16706.3 MSTRG.25520.1_1 - 0.002 18.0 0.0 2.1 8.3 0.0 2.6 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain Protocadherin PF08374.9 MSTRG.25520.1_1 - 0.06 13.2 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Protocadherin C2-set_2 PF08205.10 MSTRG.25520.1_1 - 0.092 12.7 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Sugar_tr PF00083.22 MSTRG.16447.1_1 - 3.2e-85 286.5 14.9 2e-59 201.5 5.9 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.14 MSTRG.16447.1_1 - 7.3e-25 87.5 44.6 4.9e-21 74.9 25.0 3.3 3 1 0 3 3 3 2 Major Facilitator Superfamily Peptidase_M10 PF00413.22 MSTRG.14129.1_2 - 5.8e-52 175.6 0.1 8.4e-52 175.1 0.1 1.2 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 MSTRG.14129.1_2 - 4.3e-31 106.5 6.5 1.7e-13 50.2 0.5 4.8 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.16 MSTRG.14129.1_2 - 3.4e-12 46.2 0.0 7.4e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.22 MSTRG.14129.1_2 - 3.9e-05 23.2 0.2 0.099 12.1 0.1 2.2 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.4 MSTRG.14129.1_2 - 0.00075 19.9 0.1 0.0014 19.0 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.3 MSTRG.14129.1_2 - 0.0026 16.9 0.2 0.0041 16.3 0.2 1.2 1 0 0 1 1 1 1 Met-zincin Reprolysin_4 PF13583.4 MSTRG.14129.1_2 - 0.032 13.7 0.0 0.052 13.0 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.4 MSTRG.14129.1_2 - 0.12 12.4 0.3 0.21 11.6 0.3 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M57 PF12388.6 MSTRG.14129.1_2 - 0.17 11.3 0.1 0.33 10.4 0.1 1.4 2 0 0 2 2 2 0 Dual-action HEIGH metallo-peptidase Peptidase_M66 PF10462.7 MSTRG.14129.1_2 - 0.2 10.5 0.3 0.31 9.8 0.3 1.2 1 0 0 1 1 1 0 Peptidase M66 zf-H2C2_2 PF13465.4 MSTRG.10476.1_3 - 4.8e-15 55.1 21.6 3.4e-08 33.4 1.1 4.3 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.10476.1_3 - 1.2e-11 44.3 21.7 0.00032 20.9 4.4 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.10476.1_3 - 3.2e-11 42.9 22.0 0.00011 22.5 0.6 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.10476.1_3 - 0.00046 19.9 19.7 0.027 14.3 0.4 4.2 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.10476.1_3 - 0.001 19.2 0.1 0.001 19.2 0.1 3.0 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.3 MSTRG.10476.1_3 - 0.0038 17.5 11.1 1.9 8.9 0.0 3.4 1 1 2 3 3 3 2 C2HE / C2H2 / C2HC zinc-binding finger zf-Di19 PF05605.10 MSTRG.10476.1_3 - 0.21 11.8 9.2 0.9 9.7 2.8 2.4 1 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.3 MSTRG.10476.1_3 - 0.37 11.0 7.7 2.7 8.2 2.8 2.8 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-met PF12874.5 MSTRG.10476.1_3 - 0.38 11.1 16.0 2.2 8.6 0.6 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-trcl PF13451.4 MSTRG.10476.1_3 - 1.5 8.6 6.1 15 5.4 0.1 3.3 3 0 0 3 3 3 0 Probable zinc-ribbon domain Zn-ribbon_8 PF09723.8 MSTRG.10476.1_3 - 3.6 7.6 9.0 9.5 6.3 4.7 2.8 1 1 2 3 3 3 0 Zinc ribbon domain Actin_micro PF17003.3 MSTRG.10476.1_3 - 3.8 6.4 5.1 4.8 6.1 0.1 2.6 2 1 1 3 3 3 0 Putative actin-like family zf-BED PF02892.13 MSTRG.10476.1_3 - 5.1 7.1 16.8 14 5.7 6.4 3.2 1 1 1 2 2 2 0 BED zinc finger zf-C2H2_2 PF12756.5 MSTRG.10476.1_3 - 5.5 7.3 9.0 4.4 7.6 0.0 3.0 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-LYAR PF08790.9 MSTRG.10476.1_3 - 5.9 6.8 9.5 10 6.0 2.4 3.2 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger Crystall PF00030.17 MSTRG.19609.1_3 - 2.1e-08 34.1 0.0 3e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Beta/Gamma crystallin Bromodomain PF00439.23 MSTRG.22204.2_1 - 8.7e-24 83.3 0.2 1.7e-23 82.4 0.2 1.5 1 0 0 1 1 1 1 Bromodomain DDT PF02791.15 MSTRG.22204.2_1 - 0.012 15.8 0.6 0.028 14.6 0.6 1.6 1 0 0 1 1 1 0 DDT domain TUSC2 PF15000.4 MSTRG.22204.2_1 - 0.048 13.8 0.4 0.23 11.6 0.4 2.2 1 0 0 1 1 1 0 Tumour suppressor candidate 2 Myb_Cef PF11831.6 MSTRG.26333.2_1 - 2.8e-68 229.9 11.6 6.1e-68 228.8 5.2 3.4 4 0 0 4 4 4 2 pre-mRNA splicing factor component Myb_DNA-binding PF00249.29 MSTRG.26333.2_2 - 5.5e-21 74.3 7.5 7.1e-12 45.2 1.9 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 MSTRG.26333.2_2 - 2.6e-19 69.1 5.2 1.2e-13 50.9 4.7 2.8 1 1 1 2 2 2 2 Myb-like DNA-binding domain Rap1_C PF11626.6 MSTRG.26333.2_2 - 0.017 15.1 0.2 0.059 13.3 0.2 1.9 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Transmemb_17 PF09799.7 MSTRG.22138.1_1 - 3.4e-29 101.5 13.8 4.3e-29 101.1 13.8 1.1 1 0 0 1 1 1 1 Predicted membrane protein 7tm_1 PF00001.19 MSTRG.22138.1_1 - 0.088 11.9 1.6 2.3 7.2 0.2 2.2 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) SAM_2 PF07647.15 MSTRG.15233.4_2 - 1.7e-12 47.1 0.1 3.2e-12 46.2 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 MSTRG.15233.4_2 - 2.4e-12 47.0 0.0 3.9e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ank_5 PF13857.4 MSTRG.15233.4_3 - 2.7e-07 30.7 0.0 5.8e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.4 MSTRG.15233.4_3 - 3.1e-06 27.5 0.0 8e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.15233.4_3 - 0.00052 20.1 0.0 0.0013 18.9 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeat Ank PF00023.28 MSTRG.15233.4_3 - 0.0007 19.8 0.0 0.0023 18.2 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.5 MSTRG.15233.4_3 - 0.00085 19.7 0.0 0.0016 18.9 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) SAM_1 PF00536.28 MSTRG.15233.4_3 - 0.0092 16.3 0.0 0.018 15.3 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 MSTRG.15233.4_3 - 0.029 14.3 0.0 0.063 13.3 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Pyridoxal_deC PF00282.17 MSTRG.22717.1_1 - 0.0034 16.0 0.0 0.0049 15.5 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain CLN5 PF15014.4 MSTRG.22875.1_2 - 1.3e-166 553.6 5.6 1.9e-166 553.0 5.6 1.2 1 0 0 1 1 1 1 Ceroid-lipofuscinosis neuronal protein 5 SDA1 PF05285.10 MSTRG.19327.2_1 - 0.87 8.8 15.4 0.92 8.8 15.4 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.10 MSTRG.19327.2_1 - 1 7.3 16.9 1.2 7.2 16.9 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.12 MSTRG.19327.2_1 - 4.9 5.2 11.3 5.2 5.1 11.3 1.0 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.8 MSTRG.19327.2_1 - 7.5 5.6 20.3 8.9 5.4 20.3 1.0 1 0 0 1 1 1 0 BUD22 DUF1510 PF07423.9 MSTRG.19327.2_1 - 8.9 5.6 15.6 11 5.2 15.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) FAD_binding_4 PF01565.21 MSTRG.23814.2_3 - 4.8e-13 48.9 0.0 7.6e-13 48.3 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Tetraspannin PF00335.18 MSTRG.23214.1_1 - 8e-41 140.0 11.4 1.3e-40 139.4 11.4 1.3 1 0 0 1 1 1 1 Tetraspanin family DUF3792 PF12670.5 MSTRG.23214.1_1 - 9.5 6.3 16.4 1.2 9.2 11.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3792) RexB PF15968.3 MSTRG.1501.1_1 - 0.06 13.7 5.5 3.7 7.9 0.2 3.3 1 1 2 3 3 3 0 Membrane-anchored ion channel, Abi component He_PIG PF05345.10 MSTRG.1501.1_1 - 2 8.5 19.6 6.3 6.9 0.1 4.9 5 0 0 5 5 5 0 Putative Ig domain DUF2947 PF11163.6 MSTRG.1501.1_2 - 2.1 8.1 3.8 5.2 6.8 0.1 2.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2947) Biliv-reduc_cat PF09166.8 MSTRG.1501.1_3 - 1.6 8.9 5.0 4.6 7.5 0.8 2.6 2 1 1 3 3 3 0 Biliverdin reductase, catalytic EF-hand_1 PF00036.30 MSTRG.23185.1_2 - 1.7e-20 70.8 8.2 0.0014 17.9 0.1 6.5 6 0 0 6 6 6 5 EF hand EF-hand_7 PF13499.4 MSTRG.23185.1_2 - 1.3e-16 60.7 17.6 2.9e-05 24.3 2.1 5.2 5 0 0 5 5 5 4 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.23185.1_2 - 1.2e-15 55.9 10.9 0.031 14.1 0.0 6.5 6 0 0 6 6 6 5 EF-hand domain EF-hand_5 PF13202.4 MSTRG.23185.1_2 - 3.9e-08 32.3 16.0 0.0054 16.1 0.1 5.9 5 1 0 5 5 5 5 EF hand EF-hand_8 PF13833.4 MSTRG.23185.1_2 - 7.8e-06 25.4 9.6 0.096 12.3 0.2 4.9 4 2 1 5 5 5 3 EF-hand domain pair SERTA PF06031.11 MSTRG.14623.1_3 - 8.3e-17 60.4 1.8 1.4e-16 59.7 1.8 1.4 1 0 0 1 1 1 1 SERTA motif IER PF05760.10 MSTRG.14623.1_3 - 2.6 8.1 5.4 43 4.1 1.6 3.2 3 0 0 3 3 3 0 Immediate early response protein (IER) Peptidase_M24 PF00557.22 MSTRG.5421.3_1 - 2.7e-54 183.9 0.1 6.5e-54 182.7 0.2 1.6 2 0 0 2 2 2 1 Metallopeptidase family M24 AMP_N PF05195.14 MSTRG.5421.3_1 - 5.3e-28 97.1 0.0 1.2e-27 96.0 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain RasGEF PF00617.17 MSTRG.9108.1_3 - 0.00075 19.6 0.5 0.00075 19.6 0.5 1.9 2 1 0 2 2 2 1 RasGEF domain DUF1908 PF08926.9 MSTRG.20886.3_2 - 4.2e-118 393.4 0.2 7.9e-118 392.5 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1908) Pkinase PF00069.23 MSTRG.20886.3_2 - 8.7e-62 208.7 0.0 1.3e-61 208.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.20886.3_2 - 1.7e-27 96.2 0.0 2.9e-27 95.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.20886.3_2 - 0.00073 18.8 0.0 0.0015 17.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 MSTRG.20886.3_2 - 0.024 14.1 0.2 0.043 13.3 0.2 1.3 1 0 0 1 1 1 0 RIO1 family PDZ PF00595.22 MSTRG.20886.3_3 - 6.8e-09 35.8 0.0 1.3e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.20886.3_3 - 7e-07 29.3 0.1 1.3e-06 28.5 0.1 1.3 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.4 MSTRG.20886.3_3 - 0.016 15.1 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 Tricorn protease PDZ domain SOBP PF15279.4 MSTRG.8348.1_2 - 2.2e-53 182.8 59.6 3.2e-41 142.8 2.2 5.2 3 2 2 5 5 5 2 Sine oculis-binding protein zf-FCS PF06467.12 MSTRG.8348.1_2 - 0.13 12.1 16.0 0.12 12.3 4.0 2.7 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif RPAP2_Rtr1 PF04181.11 MSTRG.8348.1_2 - 2 8.7 6.3 32 4.8 0.1 2.6 2 0 0 2 2 2 0 Rtr1/RPAP2 family Lipocalin_7 PF14651.4 MSTRG.17591.1_3 - 7.9e-07 28.9 0.0 1.4e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Torus PF16131.3 MSTRG.7726.1_1 - 2.6e-05 24.7 0.6 2.6e-05 24.7 0.6 3.0 2 1 0 3 3 3 1 Torus domain zf-CCCH PF00642.22 MSTRG.7726.1_1 - 0.00073 19.3 10.1 0.0009 19.0 2.2 3.0 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.4 MSTRG.7726.1_1 - 0.03 14.7 1.0 0.03 14.7 1.0 2.3 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger MIP-T3 PF10243.7 MSTRG.7726.1_1 - 4.4 5.8 34.0 5.6 5.4 34.0 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 MFS_1 PF07690.14 MSTRG.82.4_3 - 1.4e-38 132.6 33.4 2.5e-34 118.6 22.8 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.5 MSTRG.82.4_3 - 0.048 12.4 16.2 0.0083 14.9 10.4 2.2 2 0 0 2 2 2 0 MFS_1 like family Endonuclease_5 PF04493.12 MSTRG.19165.1_1 - 1.3e-16 60.8 0.0 1.4e-16 60.6 0.0 1.0 1 0 0 1 1 1 1 Endonuclease V DUF99 PF01949.14 MSTRG.19165.1_1 - 0.055 12.7 0.0 0.055 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF99 IL17 PF06083.9 MSTRG.19165.1_2 - 0.035 14.5 0.3 0.039 14.3 0.3 1.3 1 0 0 1 1 1 0 Interleukin-17 CEP76-C2 PF15627.4 MSTRG.19165.1_2 - 0.081 12.3 0.1 0.084 12.3 0.1 1.3 1 0 0 1 1 1 0 CEP76 C2 domain PSRT PF07636.9 MSTRG.19165.1_3 - 0.25 10.9 0.3 0.25 10.9 0.3 1.5 2 0 0 2 2 2 0 PSRT Phos_pyr_kin PF08543.10 MSTRG.14862.1_3 - 1.7e-17 63.5 0.1 3.4e-17 62.5 0.1 1.4 1 1 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.22 MSTRG.14862.1_3 - 1.7e-11 43.9 0.0 5.1e-11 42.3 0.0 1.7 1 1 0 1 1 1 1 pfkB family carbohydrate kinase HpcH_HpaI PF03328.12 MSTRG.14862.1_3 - 0.0009 18.3 0.0 0.0014 17.7 0.0 1.2 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family SHNi-TPR PF10516.7 MSTRG.12695.2_3 - 6.5e-16 57.4 1.8 4.8e-14 51.4 0.7 2.5 2 0 0 2 2 2 1 SHNi-TPR TPR_12 PF13424.4 MSTRG.12695.2_3 - 1.4e-10 41.2 3.1 1.5e-09 37.8 1.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.12695.2_3 - 5.9e-09 35.2 0.1 0.00072 19.4 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.12695.2_3 - 6.5e-09 35.1 0.0 0.001 18.7 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.12695.2_3 - 9.4e-07 28.4 0.1 0.013 15.5 0.0 3.7 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.12695.2_3 - 0.00043 20.7 0.1 0.66 10.8 0.0 3.4 2 1 1 3 3 2 1 Tetratricopeptide repeat Paf67 PF10255.7 MSTRG.12695.2_3 - 0.0042 16.0 0.0 0.0081 15.1 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_16 PF13432.4 MSTRG.12695.2_3 - 0.0068 17.0 0.7 0.3 11.7 0.0 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.12695.2_3 - 0.021 15.3 0.1 4 8.2 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.12695.2_3 - 0.038 13.5 0.4 15 5.2 0.0 3.7 4 1 1 5 5 5 0 TPR repeat TPR_7 PF13176.4 MSTRG.12695.2_3 - 0.06 13.3 0.3 1.8 8.7 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.12695.2_3 - 0.26 11.4 4.3 1.2 9.2 1.9 3.1 2 2 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.4 MSTRG.12695.2_3 - 0.37 11.2 3.6 1.9 8.9 0.6 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.12695.2_3 - 0.39 10.6 4.1 0.39 10.5 0.1 3.1 4 0 0 4 4 4 0 Tetratricopeptide repeat HTH_Tnp_Tc5 PF03221.14 MSTRG.13807.2_1 - 1.3e-14 53.8 0.0 3.4e-14 52.5 0.0 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.11 MSTRG.13807.2_1 - 1.7e-05 24.2 0.7 4e-05 23.0 0.7 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain Mor PF08765.9 MSTRG.13807.2_1 - 0.034 14.0 0.3 0.087 12.7 0.0 1.8 2 0 0 2 2 2 0 Mor transcription activator family Glu-tRNAGln PF02686.13 MSTRG.13807.2_1 - 0.049 13.8 0.7 6.3 7.0 0.1 2.8 2 0 0 2 2 2 0 Glu-tRNAGln amidotransferase C subunit RhoGAP PF00620.25 MSTRG.18121.2_1 - 3.4e-27 95.0 0.0 5.8e-22 78.0 0.0 2.3 2 0 0 2 2 2 2 RhoGAP domain VWC PF00093.16 MSTRG.23249.1_1 - 1.5e-08 34.7 15.2 1.5e-08 34.7 15.2 3.8 3 2 0 3 3 3 1 von Willebrand factor type C domain Cys_knot PF00007.20 MSTRG.23249.1_1 - 1.4e-07 31.6 8.6 1.4e-07 31.6 8.6 2.9 1 1 2 3 3 3 1 Cystine-knot domain zf-H2C2_2 PF13465.4 MSTRG.6043.1_2 - 2.2e-16 59.4 28.2 1.4e-08 34.7 3.1 4.9 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.6043.1_2 - 1.8e-13 50.0 32.8 0.00031 20.9 2.4 4.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.6043.1_2 - 7.6e-07 29.3 34.4 0.014 16.1 5.4 4.5 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.5 MSTRG.6043.1_2 - 0.0056 16.9 27.5 0.48 10.7 4.1 4.6 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 MSTRG.6043.1_2 - 0.083 12.5 21.2 1 9.1 3.8 3.5 3 0 0 3 3 3 0 zinc-finger C2H2-type Cnn_1N PF07989.9 MSTRG.6043.1_2 - 0.11 12.4 1.1 0.22 11.5 1.1 1.4 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 Phage_lysis PF03245.11 MSTRG.6043.1_2 - 0.17 11.9 0.4 3.9 7.5 0.1 2.2 2 0 0 2 2 2 0 Bacteriophage Rz lysis protein zf-C2HE PF16278.3 MSTRG.6043.1_2 - 2.7 8.4 17.8 4.2 7.8 4.5 3.4 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger C1_4 PF07975.10 MSTRG.6043.1_2 - 3.4 7.9 12.5 1.5 9.0 0.2 2.5 2 0 0 2 2 2 0 TFIIH C1-like domain FYVE PF01363.19 MSTRG.6043.1_2 - 5.8 7.0 25.0 5.3 7.1 3.7 3.2 1 1 1 2 2 2 0 FYVE zinc finger BolA PF01722.16 MSTRG.6043.1_2 - 7.4 6.8 6.5 2.7 8.2 0.1 3.0 2 1 1 3 3 3 0 BolA-like protein WD40 PF00400.30 MSTRG.1297.1_3 - 7.7e-20 70.7 5.4 0.059 14.1 0.1 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.1297.1_3 - 6.8e-11 42.2 0.0 0.00012 22.2 0.0 3.4 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain RHD_DNA_bind PF00554.20 MSTRG.26420.1_3 - 4.5e-64 215.3 0.0 6.9e-64 214.7 0.0 1.3 1 0 0 1 1 1 1 Rel homology DNA-binding domain RHD_dimer PF16179.3 MSTRG.26420.1_3 - 2e-38 130.4 0.0 3.5e-38 129.7 0.0 1.4 1 0 0 1 1 1 1 Rel homology dimerisation domain Ank_2 PF12796.5 MSTRG.26420.1_3 - 3.2e-23 82.0 10.3 2.2e-12 47.3 0.1 5.2 2 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.4 MSTRG.26420.1_3 - 1.3e-17 61.9 10.7 0.024 15.0 0.1 7.1 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.28 MSTRG.26420.1_3 - 5e-17 61.4 22.8 0.00057 20.1 0.1 7.0 7 0 0 7 7 7 5 Ankyrin repeat Ank_4 PF13637.4 MSTRG.26420.1_3 - 1.1e-13 51.2 8.9 0.0011 19.4 0.2 6.1 3 2 3 6 6 6 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 MSTRG.26420.1_3 - 6.8e-13 48.4 18.2 1.4e-06 28.4 0.4 6.0 2 1 4 7 7 7 5 Ankyrin repeats (many copies) Death PF00531.20 MSTRG.26420.1_3 - 0.0055 16.7 0.4 0.023 14.7 0.0 2.3 3 0 0 3 3 3 1 Death domain KH_1 PF00013.27 MSTRG.24997.2_3 - 2.4e-66 219.3 10.4 3.1e-17 62.0 0.1 4.3 4 0 0 4 4 4 4 KH domain KH_2 PF07650.15 MSTRG.24997.2_3 - 3e-18 65.3 8.4 0.00017 21.2 0.3 4.3 4 0 0 4 4 4 4 KH domain DUF1897 PF09005.8 MSTRG.24997.2_3 - 1.4e-09 37.1 27.7 5.4e-07 28.8 4.0 3.5 3 0 0 3 3 3 3 Domain of unknown function (DUF1897) KH_4 PF13083.4 MSTRG.24997.2_3 - 2.3e-09 36.8 6.4 0.0082 15.9 0.0 4.3 4 0 0 4 4 4 3 KH domain RRM_5 PF13893.4 MSTRG.21161.2_1 - 2.3e-59 198.4 0.0 5.4e-51 171.3 0.0 3.1 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.20 MSTRG.21161.2_1 - 5.3e-22 77.3 0.0 2.1e-07 30.5 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 MSTRG.21161.2_1 - 8e-07 28.7 0.0 0.055 13.2 0.0 3.3 3 0 0 3 3 3 3 Occluded RNA-recognition motif RRM_3 PF08777.9 MSTRG.21161.2_1 - 0.016 15.1 0.0 0.23 11.4 0.0 2.4 3 0 0 3 3 3 0 RNA binding motif Limkain-b1 PF11608.6 MSTRG.21161.2_1 - 0.034 14.1 0.0 0.2 11.6 0.0 2.1 2 0 0 2 2 2 0 Limkain b1 ERM PF00769.17 MSTRG.24967.8_3 - 0.003 17.3 17.0 0.003 17.3 17.0 9.1 4 3 5 9 9 9 1 Ezrin/radixin/moesin family Met_10 PF02475.14 MSTRG.15916.1_3 - 1.3e-29 103.3 0.0 1.9e-29 102.7 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.12 MSTRG.15916.1_3 - 9.8e-05 21.8 0.0 0.00017 21.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.11 MSTRG.15916.1_3 - 0.0041 16.4 0.0 0.0069 15.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.4 MSTRG.15916.1_3 - 0.012 16.2 0.0 0.037 14.6 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.13 MSTRG.15916.1_3 - 0.013 15.0 0.0 0.025 14.1 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 DNA_methylase PF00145.15 MSTRG.15916.1_3 - 0.018 14.3 0.0 0.029 13.6 0.0 1.2 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase bZIP_Maf PF03131.15 MSTRG.25156.1_1 - 1.1e-33 115.4 10.7 2.1e-33 114.6 10.7 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor Maf_N PF08383.9 MSTRG.25156.1_1 - 1.7e-19 69.2 0.3 3.3e-19 68.2 0.3 1.5 1 0 0 1 1 1 1 Maf N-terminal region bZIP_1 PF00170.19 MSTRG.25156.1_1 - 0.0097 15.8 8.8 0.021 14.8 8.8 1.5 1 0 0 1 1 1 1 bZIP transcription factor vATP-synt_E PF01991.16 MSTRG.25156.1_1 - 0.15 11.4 2.2 0.24 10.7 2.2 1.3 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit bZIP_2 PF07716.13 MSTRG.25156.1_1 - 0.62 10.1 6.4 1.6 8.8 6.4 1.7 1 0 0 1 1 1 0 Basic region leucine zipper DUF1192 PF06698.9 MSTRG.25156.1_1 - 0.66 10.0 3.3 17 5.4 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) JIP_LZII PF16471.3 MSTRG.25156.1_1 - 1.8 8.7 5.2 0.24 11.5 0.8 1.7 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II ZapB PF06005.10 MSTRG.25156.1_1 - 2.4 8.5 8.4 0.32 11.4 2.5 2.2 1 1 1 2 2 2 0 Cell division protein ZapB OB_NTP_bind PF07717.14 MSTRG.6563.3_2 - 1.9e-22 79.4 0.0 4.1e-22 78.3 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.21 MSTRG.6563.3_2 - 2e-21 76.1 0.0 3.9e-21 75.2 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.29 MSTRG.6563.3_2 - 5.8e-15 55.5 0.1 1.1e-14 54.6 0.1 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.27 MSTRG.6563.3_2 - 1.9e-05 24.4 0.1 5.7e-05 22.8 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.4 MSTRG.6563.3_2 - 0.00018 21.7 0.0 0.00045 20.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.25 MSTRG.6563.3_2 - 0.002 18.5 0.2 0.091 13.1 0.2 2.4 1 1 0 1 1 1 1 ABC transporter AAA_19 PF13245.4 MSTRG.6563.3_2 - 0.0062 16.7 0.0 0.015 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.4 MSTRG.6563.3_2 - 0.0084 15.7 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain BTB PF00651.29 MSTRG.2957.2_1 - 2.4e-22 79.1 0.0 1.1e-21 76.9 0.0 2.0 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.13 MSTRG.2957.2_1 - 3.3e-12 46.3 0.1 6.6e-12 45.3 0.1 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_6 PF13964.4 MSTRG.2957.2_2 - 2.4e-12 46.5 0.0 6.7e-06 26.1 0.0 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.23 MSTRG.2957.2_2 - 4.7e-12 45.1 0.7 0.00014 21.3 0.0 3.0 2 1 0 2 2 2 2 Kelch motif Kelch_2 PF07646.13 MSTRG.2957.2_2 - 2.5e-09 36.6 0.1 0.0025 17.6 0.0 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.4 MSTRG.2957.2_2 - 0.00017 21.3 0.0 0.037 13.9 0.0 2.6 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_3 PF13415.4 MSTRG.2957.2_2 - 0.0015 18.6 1.8 3.7 7.8 0.6 3.5 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.4 MSTRG.2957.2_2 - 0.0022 17.8 0.1 0.0048 16.7 0.1 1.6 1 0 0 1 1 1 1 Kelch motif Kelch_1 PF01344.23 MSTRG.2957.2_3 - 2.7e-20 71.5 0.5 1.6e-12 46.6 0.1 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.4 MSTRG.2957.2_3 - 2.9e-16 58.9 0.2 5.4e-09 35.9 0.0 2.7 1 1 1 2 2 2 2 Kelch motif Kelch_4 PF13418.4 MSTRG.2957.2_3 - 1.5e-05 24.7 0.0 0.13 12.1 0.0 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_5 PF13854.4 MSTRG.2957.2_3 - 0.0004 20.2 0.3 0.0021 17.9 0.0 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.13 MSTRG.2957.2_3 - 0.0081 16.0 0.2 0.25 11.2 0.0 2.6 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.4 MSTRG.2957.2_3 - 0.022 14.9 0.7 0.95 9.7 0.0 3.3 3 0 0 3 3 3 0 Galactose oxidase, central domain Fcf1 PF04900.10 MSTRG.17713.1_2 - 2.4e-38 130.4 1.5 6.4e-38 129.1 1.5 1.8 1 0 0 1 1 1 1 Fcf1 Meis_PKNOX_N PF16493.3 MSTRG.10854.1_1 - 3.2e-36 123.4 0.3 6.6e-36 122.4 0.3 1.5 1 0 0 1 1 1 1 N-terminal of Homeobox Meis and PKNOX1 Homeobox_KN PF05920.9 MSTRG.10854.1_1 - 1.8e-19 69.2 1.0 3.6e-19 68.2 1.0 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 MSTRG.10854.1_1 - 1.3e-07 31.2 0.2 2.5e-07 30.3 0.2 1.5 1 0 0 1 1 1 1 Homeobox domain Laminin_G_1 PF00054.21 MSTRG.3272.2_3 - 4.7e-98 324.3 0.2 4e-33 114.3 0.1 3.3 3 0 0 3 3 3 3 Laminin G domain Laminin_G_2 PF02210.22 MSTRG.3272.2_3 - 4e-76 253.5 0.1 1.8e-26 93.0 0.2 3.3 3 0 0 3 3 3 3 Laminin G domain EGF PF00008.25 MSTRG.3272.2_3 - 1.6e-21 76.1 53.6 4.7e-07 29.9 8.1 4.7 4 0 0 4 4 4 4 EGF-like domain SEA PF01390.18 MSTRG.3272.2_3 - 3.1e-15 56.2 0.0 7.1e-15 55.1 0.0 1.5 1 0 0 1 1 1 1 SEA domain hEGF PF12661.5 MSTRG.3272.2_3 - 6e-10 39.3 37.3 0.0033 17.9 6.0 5.0 4 0 0 4 4 4 4 Human growth factor-like EGF Laminin_G_3 PF13385.4 MSTRG.3272.2_3 - 2.4e-08 34.1 0.0 0.0025 17.9 0.0 3.3 3 0 0 3 3 3 2 Concanavalin A-like lectin/glucanases superfamily Sporozoite_P67 PF05642.9 MSTRG.3272.2_3 - 1.5 6.7 3.2 2 6.2 3.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MCM PF00493.21 MSTRG.12817.1_1 - 9e-134 445.6 0.0 1.4e-133 445.0 0.0 1.3 1 0 0 1 1 1 1 MCM2/3/5 family MCM_OB PF17207.1 MSTRG.12817.1_1 - 2.3e-39 134.0 0.5 4.1e-39 133.2 0.5 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_N PF14551.4 MSTRG.12817.1_1 - 3.8e-19 69.0 2.0 1.4e-18 67.2 0.3 2.5 2 0 0 2 2 2 1 MCM N-terminal domain AAA_5 PF07728.12 MSTRG.12817.1_1 - 3.8e-08 33.3 0.2 4.3e-07 29.9 0.0 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.19 MSTRG.12817.1_1 - 5.8e-08 32.2 0.0 1.9e-05 24.0 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.9 MSTRG.12817.1_1 - 1.2e-05 25.0 0.0 2.8e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) SelB-wing_2 PF09106.9 MSTRG.12817.1_1 - 0.006 16.6 0.0 1.5 9.0 0.0 2.7 2 0 0 2 2 2 1 Elongation factor SelB, winged helix Sigma54_activat PF00158.24 MSTRG.12817.1_1 - 0.015 14.9 0.0 2.8 7.5 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA PF00004.27 MSTRG.12817.1_1 - 0.016 15.5 0.0 0.062 13.6 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DnaG_DnaB_bind PF08278.9 MSTRG.12817.1_1 - 0.067 13.6 1.7 0.23 11.9 0.2 2.4 2 0 0 2 2 2 0 DNA primase DnaG DnaB-binding CUB PF00431.18 MSTRG.7900.2_3 - 3.1e-05 24.1 0.1 1 9.6 0.0 4.5 5 0 0 5 5 5 2 CUB domain TMEM51 PF15345.4 MSTRG.7900.2_3 - 0.00091 19.0 0.0 0.0016 18.2 0.0 1.3 1 0 0 1 1 1 1 Transmembrane protein 51 EphA2_TM PF14575.4 MSTRG.7900.2_3 - 0.084 13.6 0.0 0.19 12.4 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Dicty_CTDC PF00526.16 MSTRG.7900.2_3 - 2.3 8.1 7.1 4.4 7.2 2.6 3.4 2 0 0 2 2 2 0 Dictyostelium (slime mold) repeat zf-RING_2 PF13639.4 MSTRG.7326.2_3 - 5.5e-12 45.6 10.3 5.5e-12 45.6 10.3 3.4 3 0 0 3 3 3 1 Ring finger domain zf-rbx1 PF12678.5 MSTRG.7326.2_3 - 3.5e-08 33.5 7.8 3.5e-08 33.5 7.8 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_11 PF17123.3 MSTRG.7326.2_3 - 2.6e-07 30.1 6.7 1.2e-06 28.0 6.7 2.2 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.23 MSTRG.7326.2_3 - 8.1e-07 28.7 9.2 8.1e-07 28.7 9.2 3.5 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 MSTRG.7326.2_3 - 1.3e-06 28.0 9.6 1.3e-06 28.0 9.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 MSTRG.7326.2_3 - 1.1e-05 25.0 6.7 1.1e-05 25.0 6.7 3.6 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 MSTRG.7326.2_3 - 0.00012 21.9 8.0 0.00012 21.9 8.0 2.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.5 MSTRG.7326.2_3 - 0.00067 19.5 3.0 0.0019 18.1 3.0 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.4 MSTRG.7326.2_3 - 0.0032 17.3 6.6 0.0032 17.3 6.6 3.0 3 0 0 3 3 3 1 RING-type zinc-finger Ank_2 PF12796.5 MSTRG.5384.1_3 - 0.00034 21.0 0.1 0.0014 19.1 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.5384.1_3 - 0.01 16.1 0.6 0.58 10.5 0.0 3.0 2 1 1 3 3 3 0 Ankyrin repeats (many copies) WD40 PF00400.30 MSTRG.8302.2_1 - 4.3e-26 90.5 6.8 2.1e-05 25.0 0.2 6.3 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.8302.2_1 - 2.2e-06 27.7 0.1 0.27 11.4 0.0 4.7 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 MSTRG.8302.2_1 - 0.0016 18.2 0.0 0.0078 16.0 0.0 2.0 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.3 MSTRG.8302.2_1 - 0.023 13.5 0.0 0.071 11.9 0.0 1.7 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein CTC1 PF15489.4 MSTRG.1023.1_3 - 1.9e-64 217.7 5.5 9.6e-64 215.3 5.5 2.1 1 1 0 1 1 1 1 CST, telomere maintenance, complex subunit CTC1 tRNA_anti-codon PF01336.23 MSTRG.1023.1_3 - 0.11 12.3 0.0 3.2 7.7 0.0 3.1 3 0 0 3 3 3 0 OB-fold nucleic acid binding domain DENN PF02141.19 MSTRG.17580.6_2 - 3.8e-33 114.9 1.9 8.9e-33 113.7 1.9 1.6 1 1 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.16 MSTRG.17580.6_2 - 2.2e-19 69.9 0.5 6.3e-19 68.4 0.5 1.9 1 0 0 1 1 1 1 uDENN domain HD-ZIP_N PF04618.10 MSTRG.17580.6_2 - 0.027 14.8 4.2 0.049 14.0 0.4 3.0 2 0 0 2 2 2 0 HD-ZIP protein N terminus Na_H_Exchanger PF00999.19 MSTRG.3378.1_2 - 1.9e-38 132.1 11.8 2.5e-38 131.8 11.8 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family CENP-B_N PF04218.11 MSTRG.13805.1_2 - 7.2e-07 28.6 0.8 1.8e-06 27.3 0.8 1.7 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain Mor PF08765.9 MSTRG.13805.1_2 - 0.013 15.3 0.0 0.035 13.9 0.0 1.7 1 0 0 1 1 1 0 Mor transcription activator family HTH_IclR PF09339.8 MSTRG.13805.1_2 - 0.11 12.2 0.1 0.49 10.1 0.0 2.1 2 0 0 2 2 2 0 IclR helix-turn-helix domain Annexin PF00191.18 MSTRG.7343.2_3 - 8.4e-173 560.6 35.9 2e-23 82.1 0.3 8.3 8 0 0 8 8 8 8 Annexin Myb_DNA-bind_7 PF15963.3 MSTRG.7343.2_3 - 0.0012 18.5 3.6 6.3 6.6 0.0 5.9 6 1 0 7 7 7 1 Myb DNA-binding like Peptidase_C65 PF10275.7 MSTRG.7343.2_3 - 0.0089 15.4 0.5 0.021 14.1 0.5 1.6 1 0 0 1 1 1 1 Peptidase C65 Otubain UBA_2 PF08587.9 MSTRG.7343.2_3 - 0.028 14.4 8.4 1.4 9.0 0.2 4.4 4 1 0 4 4 4 0 Ubiquitin associated domain (UBA) Sigma70_ner PF04546.11 MSTRG.7343.2_3 - 0.031 14.0 6.9 0.47 10.2 2.6 3.7 2 1 0 3 3 3 0 Sigma-70, non-essential region YlbE PF14003.4 MSTRG.7343.2_3 - 0.056 13.8 0.1 16 5.9 0.0 2.7 2 0 0 2 2 2 0 YlbE-like protein DUF2312 PF10073.7 MSTRG.7343.2_3 - 0.099 12.2 12.0 46 3.6 0.0 6.3 6 1 0 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2312) Ribosomal_S10 PF00338.20 MSTRG.8203.2_2 - 8.5e-16 57.8 0.1 1.5e-15 57.0 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e HTH_16 PF12645.5 MSTRG.8203.2_2 - 0.059 13.3 0.2 0.22 11.4 0.1 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain zf-RING_2 PF13639.4 MSTRG.9754.3_1 - 1.1e-12 47.8 4.6 1.1e-12 47.8 4.6 1.7 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 MSTRG.9754.3_1 - 2.3e-09 36.8 3.9 5.3e-09 35.7 3.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 MSTRG.9754.3_1 - 9.7e-09 35.3 2.7 2.5e-08 33.9 2.7 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.23 MSTRG.9754.3_1 - 1.1e-07 31.5 2.1 1.1e-07 31.5 2.1 1.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 MSTRG.9754.3_1 - 3e-07 30.2 1.9 6.3e-07 29.1 1.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.3 MSTRG.9754.3_1 - 3.9e-07 29.5 1.4 3.9e-07 29.5 1.4 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.4 MSTRG.9754.3_1 - 9.9e-05 22.1 0.2 9.9e-05 22.1 0.2 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 MSTRG.9754.3_1 - 0.00013 21.6 1.0 0.00013 21.6 1.0 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 MSTRG.9754.3_1 - 0.0025 17.7 1.4 0.006 16.5 1.4 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.5 MSTRG.9754.3_1 - 0.0094 15.9 1.4 0.029 14.4 1.4 1.9 1 1 0 1 1 1 1 RING-variant domain Prok-RING_4 PF14447.4 MSTRG.9754.3_1 - 0.032 14.0 2.6 0.06 13.1 2.2 1.7 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 FANCL_C PF11793.6 MSTRG.9754.3_1 - 0.096 12.7 3.3 0.24 11.5 3.3 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain Amino_oxidase PF01593.22 MSTRG.18374.1_1 - 1.7e-135 452.7 0.1 1.6e-134 449.5 0.1 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase SWIRM PF04433.15 MSTRG.18374.1_1 - 5.6e-18 65.0 0.0 2.4e-17 62.9 0.0 2.1 2 0 0 2 2 2 1 SWIRM domain NAD_binding_8 PF13450.4 MSTRG.18374.1_1 - 1.4e-14 53.9 0.5 1.2e-13 50.9 1.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 MSTRG.18374.1_1 - 3.4e-08 33.4 0.1 1.2e-07 31.6 0.0 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.12 MSTRG.18374.1_1 - 6.3e-07 28.8 0.2 2.3e-06 26.9 0.1 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.19 MSTRG.18374.1_1 - 2.5e-06 26.8 1.1 7e-06 25.4 1.1 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.25 MSTRG.18374.1_1 - 1.4e-05 25.4 0.4 1.4e-05 25.4 0.4 2.7 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 MSTRG.18374.1_1 - 5.9e-05 22.2 1.1 0.00012 21.2 1.1 1.5 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.12 MSTRG.18374.1_1 - 8.2e-05 21.3 1.0 0.00023 19.8 0.8 1.8 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.5 MSTRG.18374.1_1 - 0.00062 19.1 2.1 0.00062 19.1 2.1 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.17 MSTRG.18374.1_1 - 0.0019 17.4 0.9 0.0031 16.7 0.9 1.3 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.15 MSTRG.18374.1_1 - 0.0025 16.9 0.1 0.0045 16.1 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.4 MSTRG.18374.1_1 - 0.0065 15.6 0.1 0.0065 15.6 0.1 2.2 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.10 MSTRG.18374.1_1 - 0.061 12.2 0.7 0.093 11.6 0.2 1.5 2 0 0 2 2 2 0 Lycopene cyclase protein GIDA PF01134.20 MSTRG.18374.1_1 - 0.071 12.0 5.4 0.014 14.4 1.1 1.9 2 0 0 2 2 2 0 Glucose inhibited division protein A 2-Hacid_dh_C PF02826.17 MSTRG.18374.1_1 - 0.16 11.1 0.2 0.41 9.8 0.1 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain STAR_dimer PF16544.3 MSTRG.8675.1_3 - 7.3e-23 79.8 0.1 7.3e-23 79.8 0.1 2.0 2 0 0 2 2 2 1 Homodimerisation region of STAR domain protein Quaking_NLS PF16551.3 MSTRG.8675.1_3 - 1.7e-19 69.0 5.8 3.4e-19 68.0 5.8 1.5 1 0 0 1 1 1 1 Putative nuclear localisation signal of quaking KH_1 PF00013.27 MSTRG.8675.1_3 - 2e-05 24.2 0.0 3.9e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 KH domain DUF4519 PF15012.4 MSTRG.8675.1_3 - 0.021 14.8 0.0 0.021 14.8 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4519) ETRAMP PF09716.8 MSTRG.8675.1_3 - 1 9.3 8.4 0.17 11.8 0.6 3.5 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) BAR_3 PF16746.3 MSTRG.17811.3_2 - 3.1e-84 282.3 18.2 4e-84 281.9 18.2 1.1 1 0 0 1 1 1 1 BAR domain of APPL family TAtT PF16811.3 MSTRG.17811.3_2 - 0.022 13.9 0.0 0.041 13.0 0.0 1.3 1 0 0 1 1 1 0 TRAP transporter T-component RhoGAP PF00620.25 MSTRG.17811.3_3 - 2.6e-38 131.1 0.1 4.4e-38 130.3 0.1 1.3 1 0 0 1 1 1 1 RhoGAP domain Flu_M1 PF00598.17 MSTRG.17811.3_3 - 0.36 10.2 1.5 4.1 6.7 0.4 2.3 2 0 0 2 2 2 0 Influenza Matrix protein (M1) Cadherin PF00028.15 MSTRG.15902.1_3 - 1.2e-163 531.9 3.6 2.1e-19 69.6 0.0 11.7 12 0 0 12 12 12 11 Cadherin domain Cadherin_2 PF08266.10 MSTRG.15902.1_3 - 1.7e-10 40.5 0.0 1.3 8.8 0.0 7.7 8 0 0 8 8 8 3 Cadherin-like DUF4958 PF16319.3 MSTRG.15902.1_3 - 5.8e-08 31.2 0.1 0.015 13.3 0.1 3.9 3 1 1 4 4 4 3 Domain of unknown function (DUF4958) DUF4864 PF16156.3 MSTRG.15902.1_3 - 0.0011 19.5 0.1 0.86 10.2 0.0 2.9 2 0 0 2 2 2 2 Domain of unknown function (DUF4864) tRNA-synt_1 PF00133.20 MSTRG.1197.2_1 - 2.9e-159 531.0 0.0 3.7e-159 530.7 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.9 MSTRG.1197.2_1 - 6.2e-27 94.3 0.0 1.3e-15 56.9 0.0 3.3 3 0 0 3 3 3 3 tRNA synthetases class I (M) Anticodon_1 PF08264.11 MSTRG.1197.2_1 - 1.1e-22 80.5 0.0 1.9e-22 79.8 0.0 1.3 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1_2 PF13603.4 MSTRG.1197.2_1 - 2.7e-07 30.2 0.0 4.5e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.17 MSTRG.1197.2_1 - 0.0032 16.7 0.0 0.21 10.8 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain NGP1NT PF08153.10 MSTRG.1197.2_1 - 0.14 12.2 0.0 6 6.9 0.0 2.4 2 0 0 2 2 2 0 NGP1NT (NUC091) domain Ras PF00071.20 MSTRG.4497.1_3 - 1.6e-52 177.2 0.0 2.1e-52 176.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.4497.1_3 - 6.1e-19 68.3 0.0 1.1e-18 67.5 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.4497.1_3 - 1.5e-07 30.9 0.0 2.5e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family PET117 PF15786.3 MSTRG.4497.1_3 - 0.0041 17.2 0.0 0.007 16.5 0.0 1.3 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial GTP_EFTU PF00009.25 MSTRG.4497.1_3 - 0.11 11.9 0.0 0.33 10.3 0.0 1.7 1 1 0 2 2 2 0 Elongation factor Tu GTP binding domain Ank_2 PF12796.5 MSTRG.2952.1_2 - 7.8e-33 112.8 0.7 7e-16 58.5 0.0 2.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.2952.1_2 - 2.5e-29 101.1 2.6 1.4e-10 41.4 0.2 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 MSTRG.2952.1_2 - 1.6e-21 75.9 0.9 2.1e-07 31.0 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.2952.1_2 - 2.2e-20 72.0 3.5 4.1e-06 26.9 0.1 4.8 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.4 MSTRG.2952.1_2 - 7.3e-20 68.8 1.0 2.3e-05 24.3 0.1 4.6 4 0 0 4 4 4 3 Ankyrin repeat GILT PF03227.14 MSTRG.18820.2_2 - 2.8e-18 66.0 1.4 5.1e-18 65.1 1.4 1.4 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) DUF702 PF05142.10 MSTRG.18820.2_3 - 0.033 14.5 2.8 0.054 13.9 2.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF702) IL8 PF00048.18 MSTRG.7633.1_2 - 0.0003 20.7 0.5 0.0003 20.7 0.5 2.4 3 0 0 3 3 3 1 Small cytokines (intecrine/chemokine), interleukin-8 like PolyA_pol_arg_C PF12626.5 MSTRG.6751.1_1 - 0.1 12.5 1.4 2.1 8.2 0.2 2.1 2 0 0 2 2 2 0 Polymerase A arginine-rich C-terminus Cortexin PF11057.6 MSTRG.6751.1_3 - 3e-21 74.9 0.1 4.8e-21 74.3 0.1 1.3 1 0 0 1 1 1 1 Cortexin of kidney RGS PF00615.17 MSTRG.10299.6_1 - 1.9e-31 108.6 1.0 3.2e-31 107.9 1.0 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain RBD PF02196.13 MSTRG.10299.6_1 - 2.1e-28 98.1 0.0 7.3e-20 70.7 0.0 2.5 2 0 0 2 2 2 2 Raf-like Ras-binding domain GoLoco PF02188.15 MSTRG.10299.6_1 - 6.7e-07 28.6 2.2 1.2e-06 27.8 2.2 1.4 1 0 0 1 1 1 1 GoLoco motif TUG-UBL1 PF11470.6 MSTRG.10299.6_1 - 0.0018 18.4 0.1 0.18 12.0 0.1 2.9 3 0 0 3 3 3 1 TUG ubiquitin-like domain Arf PF00025.19 MSTRG.23496.1_1 - 2.4e-76 254.9 0.0 3e-76 254.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 MSTRG.23496.1_1 - 2e-14 53.7 0.1 2.8e-14 53.3 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 MSTRG.23496.1_1 - 9.2e-14 51.2 0.0 1.2e-13 50.9 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.18 MSTRG.23496.1_1 - 8.3e-11 41.5 0.4 4.1e-07 29.4 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.8 MSTRG.23496.1_1 - 1.2e-10 41.0 0.0 1.6e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.10 MSTRG.23496.1_1 - 1.1e-09 37.9 0.0 1.5e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 MSTRG.23496.1_1 - 0.00012 22.1 0.0 0.00019 21.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 MSTRG.23496.1_1 - 0.0034 16.8 0.2 0.014 14.8 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ArgK PF03308.14 MSTRG.23496.1_1 - 0.015 14.1 0.9 0.15 10.9 0.1 2.3 2 1 0 2 2 2 0 ArgK protein AAA_18 PF13238.4 MSTRG.23496.1_1 - 0.065 13.6 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.25 MSTRG.23496.1_1 - 0.087 13.2 0.3 0.39 11.1 0.3 1.9 1 1 0 1 1 1 0 ABC transporter FeoB_N PF02421.16 MSTRG.23496.1_1 - 0.21 11.0 0.5 0.77 9.1 0.5 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B COX6B PF02297.15 MSTRG.20610.2_2 - 1.2e-10 41.3 3.2 1.9e-10 40.7 3.2 1.2 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CHCH PF06747.11 MSTRG.20610.2_2 - 0.022 14.7 3.5 0.045 13.8 3.5 1.6 1 0 0 1 1 1 0 CHCH domain DDE_Tnp_1_2 PF13586.4 MSTRG.20610.2_2 - 0.038 14.2 0.1 0.084 13.1 0.0 1.6 2 0 0 2 2 2 0 Transposase DDE domain SH3_1 PF00018.26 MSTRG.27518.1_2 - 6.8e-39 131.1 0.2 2.4e-13 49.3 0.0 3.5 3 0 0 3 3 3 3 SH3 domain SH3_9 PF14604.4 MSTRG.27518.1_2 - 5.9e-37 125.1 0.4 5.9e-14 51.5 0.1 3.4 3 0 0 3 3 3 3 Variant SH3 domain Sorb PF02208.14 MSTRG.27518.1_2 - 1.2e-26 91.9 0.9 2.9e-26 90.8 0.9 1.6 1 0 0 1 1 1 1 Sorbin homologous domain SH3_2 PF07653.15 MSTRG.27518.1_2 - 3.5e-24 84.1 0.2 2.4e-11 43.0 0.0 3.4 3 0 0 3 3 3 3 Variant SH3 domain hSH3 PF14603.4 MSTRG.27518.1_2 - 0.13 12.7 0.0 40 4.7 0.0 3.0 3 0 0 3 3 3 0 Helically-extended SH3 domain TUDOR PF00567.22 MSTRG.27518.1_2 - 0.14 12.1 0.0 0.77 9.7 0.0 2.1 2 0 0 2 2 2 0 Tudor domain PRIMA1 PF16101.3 MSTRG.27518.1_2 - 4.1 7.3 24.8 0.14 12.0 5.7 3.8 4 0 0 4 4 4 0 Proline-rich membrane anchor 1 BTB_2 PF02214.20 MSTRG.12759.1_1 - 1e-16 60.9 0.1 2.6e-16 59.6 0.0 1.6 2 0 0 2 2 2 1 BTB/POZ domain UCR_14kD PF02271.14 MSTRG.98.1_1 - 4.9e-41 138.6 0.9 5.8e-41 138.4 0.9 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit WD40 PF00400.30 MSTRG.18023.2_2 - 5.4e-35 118.7 10.5 2e-07 31.4 0.3 7.0 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.18023.2_2 - 5.4e-11 42.5 0.4 0.0065 16.6 0.0 4.8 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 MSTRG.18023.2_2 - 3.7e-05 22.4 0.4 0.13 10.7 0.0 2.9 2 1 0 2 2 2 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.9 MSTRG.18023.2_2 - 0.00065 18.4 0.1 0.29 9.7 0.0 3.0 2 1 0 3 3 3 2 Nup133 N terminal like PA14 PF07691.10 MSTRG.18023.2_2 - 0.12 12.0 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 PA14 domain DnaJ PF00226.29 MSTRG.17672.1_1 - 1.2e-20 73.3 0.1 1.8e-20 72.7 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain Myb_DNA-bind_4 PF13837.4 MSTRG.18561.1_1 - 9e-20 70.7 0.7 9e-20 70.7 0.7 2.2 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain DUF737 PF05300.9 MSTRG.18561.1_1 - 0.0069 16.6 2.3 0.01 16.1 2.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF737) MADF_DNA_bdg PF10545.7 MSTRG.18561.1_1 - 0.01 16.0 0.7 0.01 16.0 0.7 2.4 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-binding PF00249.29 MSTRG.18561.1_1 - 0.055 13.5 0.6 0.51 10.4 0.6 2.3 1 1 0 1 1 1 0 Myb-like DNA-binding domain MRP-S27 PF10037.7 MSTRG.18561.1_1 - 2.8 6.6 7.6 4.1 6.1 7.6 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 DUF229 PF02995.15 MSTRG.18561.1_3 - 0.0055 15.2 0.0 0.0071 14.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF229) FMO-like PF00743.17 MSTRG.27359.1_2 - 0.23 9.7 0.0 0.27 9.5 0.0 1.0 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like zf-LITAF-like PF10601.7 MSTRG.27359.1_3 - 1.7e-07 31.3 1.0 2.2e-07 30.9 1.0 1.2 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain Pkinase_Tyr PF07714.15 MSTRG.24415.1_2 - 2.1e-97 325.4 0.0 2.9e-97 324.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.17 MSTRG.24415.1_2 - 1.8e-73 246.3 0.1 2.7e-73 245.7 0.1 1.3 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.23 MSTRG.24415.1_2 - 1.4e-49 168.7 0.0 2.3e-49 168.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.19 MSTRG.24415.1_2 - 3.7e-29 100.8 2.0 5.6e-14 52.1 0.1 3.3 4 0 0 4 4 4 2 Fibronectin type III domain SAM_2 PF07647.15 MSTRG.24415.1_2 - 2.2e-21 75.6 0.0 3.9e-21 74.8 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) EphA2_TM PF14575.4 MSTRG.24415.1_2 - 1.1e-20 74.1 0.0 2.7e-20 72.8 0.0 1.7 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SAM_1 PF00536.28 MSTRG.24415.1_2 - 1.9e-20 72.9 0.3 4.2e-20 71.8 0.1 1.8 2 0 0 2 2 1 1 SAM domain (Sterile alpha motif) Ephrin_rec_like PF07699.11 MSTRG.24415.1_2 - 9.9e-05 21.9 5.1 9.9e-05 21.9 5.1 2.7 2 1 1 3 3 2 1 Putative ephrin-receptor like Pur_ac_phosph_N PF16656.3 MSTRG.24415.1_2 - 0.00012 22.5 0.0 0.0072 16.7 0.0 2.7 2 1 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.3 MSTRG.24415.1_2 - 0.013 15.5 0.2 1.3 9.1 0.0 2.6 2 0 0 2 2 2 0 Fibronectin type III domain Interfer-bind PF09294.8 MSTRG.24415.1_2 - 0.027 14.7 0.0 3.9 7.7 0.0 2.7 3 0 0 3 3 3 0 Interferon-alpha/beta receptor, fibronectin type III Arrestin_C PF02752.20 MSTRG.5714.1_2 - 2.2e-19 70.0 1.2 3.6e-18 66.1 0.4 2.1 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.27 MSTRG.5714.1_2 - 8.3e-16 58.2 3.0 3.2e-13 49.9 0.6 2.8 3 0 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain Rgp1 PF08737.8 MSTRG.5714.1_2 - 0.00043 19.5 2.5 0.24 10.4 0.1 2.2 2 0 0 2 2 2 2 Rgp1 TLD PF07534.14 MSTRG.24609.1_2 - 4.5e-40 137.0 0.3 8.7e-40 136.0 0.3 1.5 1 0 0 1 1 1 1 TLD LysM PF01476.18 MSTRG.24609.1_2 - 1.3e-07 31.5 0.0 2.6e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 LysM domain GRAM PF02893.18 MSTRG.24609.1_2 - 0.0015 18.2 0.1 0.0055 16.4 0.0 1.9 2 0 0 2 2 2 1 GRAM domain Chromosome_seg PF13889.4 MSTRG.16877.2_1 - 1e-20 73.5 0.3 2e-20 72.5 0.3 1.5 1 0 0 1 1 1 1 Chromosome segregation during meiosis DUF4210 PF13915.4 MSTRG.16877.2_1 - 1.2e-14 54.5 0.1 2.3e-14 53.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) HLH PF00010.24 MSTRG.24112.2_2 - 1.6e-17 63.1 1.2 1.3e-16 60.2 0.1 2.9 2 1 1 3 3 3 1 Helix-loop-helix DNA-binding domain COE1_HLH PF16423.3 MSTRG.24112.2_2 - 0.0023 17.4 0.0 0.0049 16.4 0.0 1.5 1 0 0 1 1 1 1 Transcription factor COE1 helix-loop-helix domain Lzipper-MIP1 PF14389.4 MSTRG.24112.2_2 - 0.016 15.3 6.1 0.016 15.3 6.1 2.5 2 1 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 CortBP2 PF09727.7 MSTRG.24112.2_2 - 0.31 10.8 13.7 0.051 13.4 0.8 2.3 1 1 0 2 2 2 0 Cortactin-binding protein-2 CAML PF14963.4 MSTRG.24112.2_2 - 1.5 8.7 5.7 2.4 8.1 5.7 1.3 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand Lig_chan-Glu_bd PF10613.7 MSTRG.27365.1_2 - 1.3e-31 109.0 0.1 1.3e-30 105.8 0.1 2.0 1 1 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site Lig_chan PF00060.24 MSTRG.27365.1_2 - 4.2e-20 72.0 0.1 6.1e-20 71.4 0.1 1.2 1 0 0 1 1 1 1 Ligand-gated ion channel SBP_bac_3 PF00497.18 MSTRG.27365.1_2 - 9.1e-10 38.2 0.0 1.2e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 GAIN PF16489.3 MSTRG.11721.1_3 - 7.4e-60 201.8 0.0 1e-59 201.4 0.0 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain 7tm_2 PF00002.22 MSTRG.11721.1_3 - 3.7e-56 190.0 18.4 5.1e-56 189.6 18.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.19 MSTRG.11721.1_3 - 5.1e-16 58.9 3.4 5.1e-16 58.9 3.4 3.0 3 0 0 3 3 3 1 GPCR proteolysis site, GPS, motif HRM PF02793.20 MSTRG.11721.1_3 - 1.8e-09 37.6 1.8 1.8e-09 37.6 1.8 2.2 2 0 0 2 2 2 1 Hormone receptor domain Laminin_EGF PF00053.22 MSTRG.11721.1_3 - 7.8e-08 32.2 52.2 1.4e-07 31.3 12.5 4.5 4 0 0 4 4 4 3 Laminin EGF domain Dicty_CAR PF05462.9 MSTRG.11721.1_3 - 2.4e-06 26.7 5.9 2.4e-06 26.7 5.9 1.5 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor Frizzled PF01534.15 MSTRG.11721.1_3 - 0.099 11.6 7.9 0.19 10.7 7.9 1.5 1 0 0 1 1 1 0 Frizzled/Smoothened family membrane region Adaptin_N PF01602.18 MSTRG.23696.5_3 - 2.5e-151 504.7 12.9 3.3e-151 504.3 12.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region AP3D1 PF06375.9 MSTRG.23696.5_3 - 2.5e-47 161.0 15.5 2.5e-47 161.0 15.5 3.4 2 1 1 3 3 3 1 AP-3 complex subunit delta-1 Cnd1 PF12717.5 MSTRG.23696.5_3 - 1.1e-15 57.9 6.3 5.2e-11 42.7 0.0 3.9 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.20 MSTRG.23696.5_3 - 8.5e-07 28.6 0.2 0.47 10.7 0.0 5.1 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.4 MSTRG.23696.5_3 - 1.3e-05 25.3 0.0 0.1 12.9 0.0 3.6 2 1 0 3 3 3 1 HEAT repeats RTP1_C1 PF10363.7 MSTRG.23696.5_3 - 5.7e-05 23.1 4.6 0.87 9.6 1.0 4.0 4 0 0 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 RasGEF_N_2 PF14663.4 MSTRG.23696.5_3 - 0.0065 16.7 0.1 0.17 12.1 0.3 2.7 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain Vac14_Fab1_bd PF12755.5 MSTRG.23696.5_3 - 0.13 12.7 0.1 1 9.8 0.0 2.5 1 1 1 2 2 2 0 Vacuolar 14 Fab1-binding region Pkinase PF00069.23 MSTRG.21375.1_3 - 3.9e-58 196.7 0.2 6.5e-58 196.0 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.21375.1_3 - 1.4e-25 90.0 0.1 2.2e-25 89.3 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.21375.1_3 - 2.7e-09 36.6 0.0 1.1e-06 28.0 0.0 2.3 1 1 0 2 2 2 2 Kinase-like MAS20 PF02064.13 MSTRG.21375.1_3 - 5.9e-05 23.0 1.5 0.25 11.3 0.7 2.5 2 0 0 2 2 2 2 MAS20 protein import receptor Mad3_BUB1_I_2 PF17014.3 MSTRG.21375.1_3 - 0.00041 20.3 0.1 0.2 11.6 0.0 2.8 2 0 0 2 2 2 2 Putative Mad3/BUB1 like region 1 protein Kdo PF06293.12 MSTRG.21375.1_3 - 0.0011 18.2 1.1 0.0044 16.3 0.0 2.3 3 0 0 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 MSTRG.21375.1_3 - 0.0011 18.5 0.1 1.6 8.2 0.0 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.20 MSTRG.21375.1_3 - 0.0023 17.4 0.4 0.011 15.2 0.1 2.0 1 1 1 2 2 2 1 RIO1 family APH PF01636.21 MSTRG.21375.1_3 - 0.0075 16.1 0.0 0.15 11.9 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family LRR_8 PF13855.4 MSTRG.11759.1_1 - 9.1e-34 114.9 28.2 2.3e-10 40.0 1.1 6.7 4 2 2 7 7 7 7 Leucine rich repeat LRR_4 PF12799.5 MSTRG.11759.1_1 - 3.4e-22 78.0 25.8 2.6e-06 27.5 0.2 7.3 4 2 5 9 9 9 8 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 MSTRG.11759.1_1 - 1.7e-09 36.9 19.1 0.21 11.6 0.0 9.9 11 0 0 11 11 11 3 Leucine Rich repeat LRRNT PF01462.16 MSTRG.11759.1_1 - 7.2e-09 35.0 5.9 7.2e-09 35.0 5.9 2.5 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 MSTRG.11759.1_1 - 1.5e-05 24.4 4.3 0.00074 18.9 0.9 3.3 1 1 2 3 3 3 1 Leucine-rich repeat LRR_1 PF00560.31 MSTRG.11759.1_1 - 0.00026 20.9 21.9 5.3 7.8 0.1 9.5 8 2 1 9 9 9 2 Leucine Rich Repeat zf-RING_2 PF13639.4 MSTRG.27880.1_2 - 7.1e-11 42.1 6.2 7.1e-11 42.1 6.2 3.2 3 0 0 3 3 3 1 Ring finger domain zf-RING_11 PF17123.3 MSTRG.27880.1_2 - 1.1e-10 40.9 4.3 3.7e-10 39.2 4.3 2.0 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.4 MSTRG.27880.1_2 - 2e-07 30.7 3.2 6e-07 29.2 3.2 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 MSTRG.27880.1_2 - 7.4e-07 28.8 5.9 2.4e-06 27.1 5.9 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 MSTRG.27880.1_2 - 4.2e-06 26.8 4.0 4.2e-06 26.8 4.0 2.6 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.4 MSTRG.27880.1_2 - 0.00012 21.8 2.1 0.00012 21.8 2.1 2.8 2 0 0 2 2 2 1 zinc-RING finger domain Sec7 PF01369.18 MSTRG.29565.1_1 - 1.1e-06 28.4 0.0 1.3e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Sec7 domain Cadherin_C_2 PF16492.3 MSTRG.26100.1_2 - 1.2e-25 90.0 0.2 2.5e-25 89.0 0.2 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin PF00028.15 MSTRG.26100.1_2 - 9e-11 41.9 0.0 1.6e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 Cadherin domain XhlA PF10779.7 MSTRG.7681.1_1 - 0.0088 16.1 4.9 0.012 15.6 3.3 2.0 1 1 1 2 2 2 1 Haemolysin XhlA DUF1664 PF07889.10 MSTRG.7681.1_1 - 0.0091 15.8 0.5 0.014 15.2 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) DUF4649 PF15507.4 MSTRG.7681.1_1 - 0.014 15.2 0.3 0.026 14.3 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4649) DUF745 PF05335.11 MSTRG.7681.1_1 - 0.067 12.8 0.3 0.087 12.4 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Profilin PF00235.17 MSTRG.12105.3_2 - 1.9e-28 99.1 0.3 2.4e-28 98.8 0.3 1.1 1 0 0 1 1 1 1 Profilin VPS9 PF02204.16 MSTRG.965.1_3 - 9.7e-29 99.5 0.0 1.9e-28 98.5 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain EST1 PF10374.7 MSTRG.965.1_3 - 0.022 15.3 0.3 0.2 12.1 0.0 2.5 2 1 0 2 2 2 0 Telomerase activating protein Est1 Apolipoprotein PF01442.16 MSTRG.965.1_3 - 0.053 13.3 1.7 1.5 8.6 0.0 2.2 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain fn3 PF00041.19 MSTRG.17465.2_3 - 2.2e-13 50.2 0.0 1.1e-07 31.9 0.1 2.4 2 0 0 2 2 2 2 Fibronectin type III domain SPRY PF00622.26 MSTRG.17465.2_3 - 7.6e-13 48.5 0.1 1.5e-12 47.6 0.1 1.4 1 0 0 1 1 1 1 SPRY domain PRY PF13765.4 MSTRG.17465.2_3 - 0.00019 20.8 0.0 0.00054 19.4 0.0 1.8 1 0 0 1 1 1 1 SPRY-associated domain BRE PF06113.10 MSTRG.1674.2_1 - 1.1e-95 320.0 0.0 1.3e-95 319.8 0.0 1.0 1 0 0 1 1 1 1 Brain and reproductive organ-expressed protein (BRE) Glyco_hydro_47 PF01532.18 MSTRG.6826.2_2 - 3.4e-146 487.6 0.0 4.1e-146 487.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 CDK5_activator PF03261.13 MSTRG.16349.1_1 - 1.1e-07 31.6 0.9 1.5e-07 31.1 0.9 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase 5 activator protein Ank_2 PF12796.5 MSTRG.2952.2_1 - 7.2e-33 112.9 0.2 7e-16 58.5 0.0 2.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.2952.2_1 - 2.6e-29 101.1 2.6 1.4e-10 41.4 0.2 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 MSTRG.2952.2_1 - 1.6e-21 75.9 0.9 2.1e-07 30.9 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.2952.2_1 - 2.6e-20 71.8 3.9 4.1e-06 26.9 0.1 4.8 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.4 MSTRG.2952.2_1 - 8.6e-20 68.6 1.0 2.3e-05 24.3 0.1 4.5 4 0 0 4 4 4 3 Ankyrin repeat Laminin_N PF00055.15 MSTRG.8735.1_1 - 2e-46 158.3 3.8 1.3e-45 155.7 0.0 2.1 2 0 0 2 2 2 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.22 MSTRG.8735.1_1 - 1.6e-08 34.4 10.7 5e-08 32.8 10.7 1.9 1 0 0 1 1 1 1 Laminin EGF domain BNR PF02012.18 MSTRG.8735.1_1 - 0.013 15.3 1.6 1.8 8.7 0.2 2.9 2 0 0 2 2 2 0 BNR/Asp-box repeat PhoLip_ATPase_C PF16212.3 MSTRG.12489.1_2 - 5.2e-79 265.4 32.3 5.2e-79 265.4 32.3 2.7 4 0 0 4 4 4 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.3 MSTRG.12489.1_2 - 2.3e-22 78.4 0.6 2.3e-22 78.4 0.6 2.7 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.18 MSTRG.12489.1_2 - 1.3e-12 47.4 0.0 1.3e-12 47.4 0.0 2.7 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase PF13246.4 MSTRG.12489.1_2 - 8.8e-10 38.4 0.1 1.8e-08 34.2 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 MSTRG.12489.1_2 - 9.8e-09 35.7 1.4 4e-05 23.9 1.3 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.10 MSTRG.12489.1_2 - 0.0058 16.3 0.1 0.089 12.4 0.0 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Ca_hom_mod PF14798.4 MSTRG.1227.1_1 - 7.7e-76 254.4 0.8 1.2e-75 253.8 0.8 1.2 1 0 0 1 1 1 1 Calcium homeostasis modulator DUF350 PF03994.12 MSTRG.1227.1_1 - 0.088 12.8 1.1 0.23 11.5 1.1 1.7 1 0 0 1 1 1 0 Domain of Unknown Function (DUF350) Filamin PF00630.17 MSTRG.12971.4_3 - 1.7e-12 47.9 0.0 1.9e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 Filamin/ABP280 repeat PEGA PF08308.9 MSTRG.12971.4_3 - 0.062 13.1 0.0 0.88 9.4 0.0 2.0 1 1 1 2 2 2 0 PEGA domain zf-DHHC PF01529.18 MSTRG.5555.1_2 - 2.2e-28 98.9 8.0 2.2e-28 98.9 8.0 3.4 3 0 0 3 3 3 1 DHHC palmitoyltransferase Sema PF01403.17 MSTRG.570.1_2 - 3.3e-08 32.6 0.0 3.4e-08 32.5 0.0 1.0 1 0 0 1 1 1 1 Sema domain I-set PF07679.14 MSTRG.215.3_3 - 3.9e-241 779.9 51.8 2e-15 56.5 0.1 24.4 24 0 0 24 24 24 23 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.215.3_3 - 5e-137 446.7 18.8 4.6e-09 36.6 0.0 24.2 24 0 0 24 24 24 20 Immunoglobulin domain ig PF00047.23 MSTRG.215.3_3 - 1.4e-76 252.6 31.4 1e-07 31.9 0.0 21.4 22 0 0 22 22 22 14 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.215.3_3 - 8.7e-73 240.6 17.8 7.7e-06 26.0 0.1 20.0 21 0 0 21 21 21 11 Immunoglobulin domain fn3 PF00041.19 MSTRG.215.3_3 - 1.1e-43 147.3 4.6 7.6e-14 51.7 0.2 4.9 4 0 0 4 4 4 3 Fibronectin type III domain V-set PF07686.15 MSTRG.215.3_3 - 1e-32 112.4 41.8 0.014 15.4 0.2 23.9 19 8 1 20 20 19 9 Immunoglobulin V-set domain Izumo-Ig PF16706.3 MSTRG.215.3_3 - 2.2e-13 49.9 38.4 0.16 11.9 0.1 15.8 16 0 0 16 16 16 3 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.6 MSTRG.215.3_3 - 6.6e-10 39.0 2.8 1.2 9.3 0.0 8.8 8 0 0 8 8 8 2 Natural killer cell receptor 2B4 Ig_4 PF16680.3 MSTRG.215.3_3 - 3.5e-09 36.8 44.4 0.056 13.7 0.5 12.9 14 0 0 14 14 13 4 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.3 MSTRG.215.3_3 - 3.9e-09 36.7 43.5 0.16 12.3 0.2 12.7 12 1 1 13 13 12 4 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Pur_ac_phosph_N PF16656.3 MSTRG.215.3_3 - 0.00052 20.4 10.5 1.2 9.6 0.1 5.9 5 1 0 5 5 3 1 Purple acid Phosphatase, N-terminal domain Methyltransf_18 PF12847.5 MSTRG.215.3_3 - 0.086 12.6 0.0 5.9 6.7 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase domain V-set_CD47 PF08204.9 MSTRG.215.3_3 - 1.4 8.8 9.0 7 6.5 0.1 5.5 7 0 0 7 7 7 0 CD47 immunoglobulin-like domain KGG PF10685.7 MSTRG.6966.2_2 - 3.1 8.1 7.5 0.64 10.2 3.2 2.1 2 0 0 2 2 2 0 Stress-induced bacterial acidophilic repeat motif TIM PF00121.16 MSTRG.6966.2_3 - 1.3e-86 289.8 0.1 1.7e-86 289.4 0.1 1.1 1 0 0 1 1 1 1 Triosephosphate isomerase DAZAP2 PF11029.6 MSTRG.488.1_2 - 4.7e-47 160.0 18.4 4.7e-47 160.0 18.4 1.7 2 0 0 2 2 2 1 DAZ associated protein 2 (DAZAP2) Exo_endo_phos PF03372.21 MSTRG.8253.1_1 - 2.9e-15 56.4 0.0 5e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family MAT1 PF06391.11 MSTRG.28728.1_3 - 4.5e-08 33.0 0.1 6e-08 32.6 0.1 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 TTL PF03133.13 MSTRG.8376.1_2 - 6.4e-06 25.4 0.0 8.6e-06 24.9 0.0 1.3 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family MBT PF02820.16 MSTRG.15304.1_3 - 3e-08 33.8 0.2 9.1e-06 25.8 0.0 2.2 2 0 0 2 2 2 2 mbt repeat Histone_H2A_C PF16211.3 MSTRG.2330.1_2 - 1.9e-21 75.3 1.7 3.1e-21 74.7 1.7 1.3 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.22 MSTRG.2330.1_2 - 7.1e-17 61.9 0.0 9.7e-17 61.5 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 MSTRG.2330.1_2 - 0.00018 21.6 0.0 0.00029 20.9 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Pkinase PF00069.23 MSTRG.10669.2_2 - 3.2e-66 223.3 0.0 4.6e-66 222.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.10669.2_2 - 3.1e-29 101.9 0.0 4.6e-29 101.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 MSTRG.10669.2_2 - 4.3e-06 26.1 0.1 7.1e-06 25.4 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Cyclin_N PF00134.21 MSTRG.1895.1_1 - 1.5e-27 95.8 0.2 2.6e-27 95.0 0.2 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 MSTRG.1895.1_1 - 3.3e-07 30.3 0.1 7e-07 29.2 0.1 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain SIT PF15330.4 MSTRG.27926.2_1 - 0.097 13.0 0.0 0.17 12.2 0.0 1.5 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Trp_leader2 PF08056.9 MSTRG.27926.2_2 - 0.39 10.6 6.1 0.72 9.7 6.1 1.4 1 0 0 1 1 1 0 Tryptophan operon leader peptide GOLGA2L5 PF15070.4 MSTRG.13133.2_3 - 3.5e-275 914.4 65.0 3.5e-275 914.4 65.0 2.3 2 0 0 2 2 2 1 Putative golgin subfamily A member 2-like protein 5 Atg14 PF10186.7 MSTRG.13133.2_3 - 0.00033 19.7 3.6 0.00033 19.7 3.6 7.1 2 2 4 6 6 6 1 Vacuolar sorting 38 and autophagy-related subunit 14 F-actin_cap_A PF01267.15 MSTRG.20300.1_3 - 7.6e-104 346.7 0.1 9.5e-104 346.4 0.1 1.1 1 0 0 1 1 1 1 F-actin capping protein alpha subunit SMC_N PF02463.17 MSTRG.23008.2_1 - 1.5e-51 174.8 63.3 9.3e-28 97.0 21.3 3.4 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.11 MSTRG.23008.2_1 - 3.2e-27 95.0 0.2 1.6e-26 92.8 0.0 2.4 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.4 MSTRG.23008.2_1 - 4.3e-12 46.3 0.8 1.3e-07 31.6 0.0 4.0 4 1 1 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.4 MSTRG.23008.2_1 - 4.5e-11 42.8 27.1 4.5e-11 42.8 27.1 4.2 2 2 2 4 4 4 1 AAA ATPase domain AAA_23 PF13476.4 MSTRG.23008.2_1 - 2.3e-08 34.7 46.5 2.3e-08 34.7 46.5 7.8 3 2 2 5 5 5 1 AAA domain AAA_29 PF13555.4 MSTRG.23008.2_1 - 4.9e-08 32.4 0.0 9.1e-08 31.6 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain Reo_sigmaC PF04582.10 MSTRG.23008.2_1 - 0.22 10.8 24.4 1.3 8.2 0.3 5.1 4 1 1 5 5 5 0 Reovirus sigma C capsid protein Skp1_POZ PF03931.13 MSTRG.5060.1_1 - 0.091 12.8 0.1 0.13 12.3 0.1 1.2 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain PWWP PF00855.15 MSTRG.6102.1_1 - 2.5e-14 53.4 0.1 5e-14 52.4 0.1 1.5 1 0 0 1 1 1 1 PWWP domain RRM_1 PF00076.20 MSTRG.13796.8_3 - 6e-14 51.5 0.0 9.8e-14 50.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.13796.8_3 - 0.02 14.9 0.0 0.036 14.0 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif Ank_2 PF12796.5 MSTRG.12681.1_1 - 2e-28 98.7 2.5 6.6e-13 48.9 0.3 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.28 MSTRG.12681.1_1 - 1.8e-22 78.6 4.6 4.9e-06 26.6 0.1 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.4 MSTRG.12681.1_1 - 3.8e-22 77.9 3.0 5.2e-11 42.4 0.1 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 MSTRG.12681.1_1 - 7.5e-21 74.1 5.1 1.6e-07 31.6 0.1 4.8 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.12681.1_1 - 4.4e-19 66.4 2.2 8.6e-07 28.7 0.1 5.7 5 0 0 5 5 5 3 Ankyrin repeat C1-set PF07654.13 MSTRG.10923.2_2 - 8.2e-16 58.1 0.6 1.4e-07 31.8 0.4 2.4 2 0 0 2 2 2 2 Immunoglobulin C1-set domain Ig_3 PF13927.4 MSTRG.10923.2_2 - 3.6e-11 43.4 0.9 2e-05 25.0 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 MSTRG.10923.2_2 - 1.1e-08 35.0 0.2 0.0035 17.3 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 MSTRG.10923.2_2 - 3e-07 30.3 0.2 0.017 15.1 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain C2-set_2 PF08205.10 MSTRG.10923.2_2 - 0.043 13.8 0.5 1.4 8.9 0.0 2.5 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain DUF3357 PF11837.6 MSTRG.10923.2_2 - 0.13 12.6 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) zf-H2C2_5 PF13909.4 MSTRG.22166.2_2 - 5.9e-07 29.0 1.0 1.3e-06 27.9 1.0 1.7 1 0 0 1 1 1 1 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 MSTRG.22166.2_2 - 0.002 18.3 0.2 0.0049 17.1 0.2 1.6 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.22166.2_2 - 0.1 13.3 1.3 0.18 12.6 0.6 1.8 1 1 1 2 2 2 0 C2H2-type zinc finger zf-H2C2_2 PF13465.4 MSTRG.22166.2_2 - 6.3 7.3 9.4 0.86 10.0 1.4 2.6 3 0 0 3 3 3 0 Zinc-finger double domain DUF3534 PF12053.6 MSTRG.4123.2_3 - 3.7e-15 56.4 0.2 3.7e-15 56.4 0.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3534) PDZ PF00595.22 MSTRG.4123.2_3 - 7.3e-15 55.0 0.9 1.1e-06 28.7 0.1 2.9 3 0 0 3 3 3 2 PDZ domain (Also known as DHR or GLGF) Filament PF00038.19 MSTRG.11243.1_1 - 0.54 9.7 54.6 11 5.3 54.6 2.1 1 1 0 1 1 1 0 Intermediate filament protein NHR2 PF08788.9 MSTRG.23276.1_2 - 5.5e-40 134.8 8.6 1.6e-39 133.4 8.6 1.8 1 0 0 1 1 1 1 NHR2 domain like TAFH PF07531.12 MSTRG.23276.1_2 - 8e-34 115.4 1.2 1.4e-33 114.6 1.2 1.4 1 0 0 1 1 1 1 NHR1 homology to TAF Cys_knot PF00007.20 MSTRG.2794.1_3 - 1.6e-14 53.9 11.1 1.6e-14 53.9 11.1 3.9 3 1 1 4 4 4 1 Cystine-knot domain IGFBP PF00219.16 MSTRG.2794.1_3 - 9.4e-11 42.1 22.9 9.4e-11 42.1 22.9 5.9 3 2 2 5 5 5 1 Insulin-like growth factor binding protein VWC PF00093.16 MSTRG.2794.1_3 - 6.4e-10 39.1 10.4 6.4e-10 39.1 10.4 4.9 3 2 1 4 4 4 1 von Willebrand factor type C domain Crystall PF00030.17 MSTRG.26695.1_3 - 3.4e-60 200.1 4.3 2e-29 101.4 1.6 2.0 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 MSTRG.26695.1_3 - 0.0019 17.9 3.4 1.3 8.9 0.1 2.9 2 1 0 2 2 2 2 Peptidase inhibitor family I36 Crystall_3 PF08964.8 MSTRG.26695.1_3 - 0.0025 17.8 1.4 0.14 12.2 0.4 2.6 2 1 1 3 3 3 2 Beta/Gamma crystallin HLH PF00010.24 MSTRG.15707.1_1 - 9.2e-19 67.0 1.1 9.6e-19 67.0 0.1 1.6 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain ABC2_membrane_3 PF12698.5 MSTRG.25792.1_1 - 4.7e-56 190.2 27.7 1.4e-40 139.4 12.5 3.1 2 1 0 2 2 2 2 ABC-2 family transporter protein ABC_tran PF00005.25 MSTRG.25792.1_1 - 1e-51 174.9 0.0 1.4e-28 100.0 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.4 MSTRG.25792.1_1 - 8.6e-20 71.6 0.0 1e-06 28.7 0.0 4.4 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.4 MSTRG.25792.1_1 - 0.00079 20.0 0.0 0.89 10.2 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4162) AAA_29 PF13555.4 MSTRG.25792.1_1 - 0.007 15.9 2.4 0.17 11.5 0.5 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_23 PF13476.4 MSTRG.25792.1_1 - 0.0094 16.3 4.9 0.14 12.5 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.4 MSTRG.25792.1_1 - 0.02 14.4 0.0 7.3 6.0 0.0 2.7 3 0 0 3 3 3 0 AAA ATPase domain SRP54 PF00448.20 MSTRG.25792.1_1 - 0.025 14.1 1.5 4.4 6.8 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MukB PF04310.10 MSTRG.25792.1_1 - 5.4 6.6 5.4 2.4 7.8 0.1 2.6 3 0 0 3 3 3 0 MukB N-terminal RabGAP-TBC PF00566.16 MSTRG.11716.1_2 - 1.5e-52 178.3 2.6 2e-52 177.9 2.6 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF4864 PF16156.3 MSTRG.11716.1_2 - 0.071 13.7 0.0 0.17 12.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4864) ANAPC15 PF15243.4 MSTRG.17072.1_2 - 1.4e-36 124.7 13.7 1.4e-36 124.7 13.7 1.7 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 15 RNA_pol_3_Rpc31 PF11705.6 MSTRG.17072.1_2 - 0.013 15.6 14.6 0.018 15.2 14.6 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF4746 PF15928.3 MSTRG.17072.1_2 - 0.14 11.4 6.5 0.18 11.0 6.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) VID27 PF08553.8 MSTRG.17072.1_2 - 0.25 9.7 6.8 0.3 9.4 6.8 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein Med8 PF10232.7 MSTRG.17072.1_2 - 0.25 10.8 2.8 0.34 10.3 2.8 1.1 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 RRM_1 PF00076.20 MSTRG.2585.1_1 - 6.2e-27 93.1 0.1 2.1e-15 56.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.2585.1_1 - 8.3e-07 28.9 0.1 0.055 13.5 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.9 MSTRG.2585.1_1 - 0.02 14.8 0.0 0.52 10.3 0.0 2.3 2 0 0 2 2 2 0 RNA binding motif Defensin_2 PF01097.16 MSTRG.2585.1_2 - 4.6 7.1 9.6 0.84 9.5 3.3 2.7 2 0 0 2 2 2 0 Arthropod defensin SMP_LBD PF17047.3 MSTRG.11077.2_1 - 7e-97 322.0 0.2 1.1e-96 321.3 0.2 1.3 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain C2 PF00168.28 MSTRG.11077.2_1 - 1.2e-52 176.4 0.1 9.2e-21 73.9 0.0 3.5 3 0 0 3 3 3 3 C2 domain SH2 PF00017.22 MSTRG.23711.1_1 - 6.4e-17 61.2 0.0 1e-16 60.6 0.0 1.3 1 0 0 1 1 1 1 SH2 domain 7tm_1 PF00001.19 MSTRG.4288.1_2 - 1e-20 74.0 1.0 1.3e-20 73.6 1.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TGF_beta_GS PF08515.10 MSTRG.4288.1_2 - 0.17 11.3 0.9 0.3 10.5 0.9 1.4 1 0 0 1 1 1 0 Transforming growth factor beta type I GS-motif TFIIE_beta PF02186.13 MSTRG.27962.1_2 - 1.3e-20 73.3 1.6 2e-20 72.7 0.1 2.1 3 0 0 3 3 3 1 TFIIE beta subunit core domain EF-hand_11 PF08976.9 MSTRG.27962.1_2 - 0.0045 17.7 0.0 0.008 16.9 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain DUF4195 PF13836.4 MSTRG.27962.1_2 - 0.0048 16.9 0.9 0.013 15.5 0.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4195) EF-hand_7 PF13499.4 MSTRG.26544.3_3 - 5.8e-25 87.4 8.3 5.9e-24 84.2 2.2 3.6 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.30 MSTRG.26544.3_3 - 1.6e-05 24.0 0.2 0.086 12.3 0.1 4.5 6 0 0 6 6 6 1 EF hand EF-hand_6 PF13405.4 MSTRG.26544.3_3 - 3.5e-05 23.3 0.4 0.055 13.3 0.0 4.2 4 0 0 4 4 4 1 EF-hand domain EF-hand_5 PF13202.4 MSTRG.26544.3_3 - 0.00028 20.1 0.0 0.0034 16.7 0.0 2.8 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.4 MSTRG.26544.3_3 - 0.0088 15.7 1.0 0.88 9.3 0.0 4.3 7 0 0 7 7 7 1 EF-hand domain pair SPARC_Ca_bdg PF10591.7 MSTRG.26544.3_3 - 0.11 12.7 4.8 5.2 7.3 0.2 3.0 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region RhoGEF PF00621.18 MSTRG.11811.1_1 - 3.4e-47 160.9 0.1 6e-47 160.1 0.1 1.4 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 MSTRG.11811.1_1 - 6.2e-20 71.5 0.0 4.8e-12 46.2 0.0 2.6 2 0 0 2 2 2 2 PH domain FYVE PF01363.19 MSTRG.11811.1_1 - 7.5e-12 45.1 13.8 2.8e-11 43.3 13.8 2.0 1 0 0 1 1 1 1 FYVE zinc finger PH_11 PF15413.4 MSTRG.11811.1_1 - 0.0011 19.2 0.2 1.1 9.5 0.0 3.2 3 0 0 3 3 3 2 Pleckstrin homology domain PH_5 PF15405.4 MSTRG.11811.1_1 - 0.14 12.1 0.3 18 5.3 0.0 2.4 1 1 1 2 2 2 0 Pleckstrin homology domain Foie-gras_1 PF11817.6 MSTRG.14360.1_2 - 8e-72 241.8 0.1 1.4e-71 241.0 0.1 1.4 1 0 0 1 1 1 1 Foie gras liver health family 1 Gryzun-like PF12742.5 MSTRG.14360.1_2 - 7.6e-21 73.7 0.1 1.5e-20 72.8 0.1 1.5 1 0 0 1 1 1 1 Gryzun, putative Golgi trafficking Gryzun PF07919.10 MSTRG.14360.1_2 - 1.8e-12 46.8 0.0 2.2e-09 36.5 0.0 2.7 2 1 1 3 3 3 2 Gryzun, putative trafficking through Golgi TPR_2 PF07719.15 MSTRG.14360.1_2 - 0.047 13.7 2.2 2.1 8.5 0.4 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat UCH PF00443.27 MSTRG.7147.3_1 - 1.1e-49 169.1 1.5 2.5e-49 167.9 0.1 2.2 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 MSTRG.7147.3_1 - 5.3e-09 36.0 1.7 5.3e-09 36.0 1.7 2.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase MerR-DNA-bind PF09278.9 MSTRG.7147.3_1 - 0.056 13.9 0.8 7.2 7.1 0.0 2.9 2 0 0 2 2 2 0 MerR, DNA binding Peptidase_C98 PF15499.4 MSTRG.7147.3_1 - 0.69 9.2 3.2 12 5.2 0.3 2.7 3 0 0 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase TTD PF12148.6 MSTRG.6237.1_3 - 2.8e-59 199.3 0.0 4.7e-59 198.6 0.0 1.4 1 0 0 1 1 1 1 Tandem tudor domain within UHRF1 SAD_SRA PF02182.15 MSTRG.6237.1_3 - 3.3e-48 163.0 0.1 6.1e-48 162.2 0.1 1.5 1 0 0 1 1 1 1 SAD/SRA domain ubiquitin PF00240.21 MSTRG.6237.1_3 - 2.1e-14 52.9 0.6 2.1e-14 52.9 0.6 2.6 3 0 0 3 3 3 1 Ubiquitin family PHD PF00628.27 MSTRG.6237.1_3 - 4e-10 39.3 10.4 4e-10 39.3 10.4 4.1 4 0 0 4 4 4 1 PHD-finger Prok-RING_4 PF14447.4 MSTRG.6237.1_3 - 0.0026 17.5 10.1 0.0026 17.5 10.1 3.6 3 1 0 3 3 3 1 Prokaryotic RING finger family 4 Rad60-SLD PF11976.6 MSTRG.6237.1_3 - 0.0037 16.9 0.3 0.0063 16.2 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like FXMRP1_C_core PF12235.6 MSTRG.6237.1_3 - 6.1 7.4 10.4 0.77 10.3 5.3 2.1 2 0 0 2 2 2 0 Fragile X-related 1 protein core C terminal PMP22_Claudin PF00822.18 MSTRG.27069.1_2 - 8e-27 94.0 10.5 1e-26 93.7 10.5 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 MSTRG.27069.1_2 - 6.1e-05 22.7 16.3 0.00027 20.6 13.5 2.6 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction Clc-like PF07062.10 MSTRG.27069.1_2 - 1.2 8.4 7.3 0.13 11.6 2.5 1.8 1 1 1 2 2 2 0 Clc-like ubiquitin PF00240.21 MSTRG.5481.4_2 - 9.2e-07 28.4 0.0 1.5e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family BTB PF00651.29 MSTRG.249.1_2 - 0.0003 20.8 0.0 0.00053 20.0 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain RGS-like PF09128.9 MSTRG.25820.2_2 - 5.9e-29 101.0 0.1 1e-28 100.2 0.1 1.4 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain PDZ PF00595.22 MSTRG.25820.2_2 - 1.1e-11 44.8 0.4 2e-11 43.9 0.4 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.25820.2_2 - 1.9e-06 27.9 0.1 4.4e-06 26.8 0.1 1.5 1 0 0 1 1 1 1 PDZ domain RGS PF00615.17 MSTRG.25820.2_2 - 2.7e-06 27.5 0.0 8.4e-06 25.9 0.0 1.7 2 0 0 2 2 2 1 Regulator of G protein signaling domain RhoGAP PF00620.25 MSTRG.23103.2_1 - 4.7e-45 153.0 0.0 1.1e-44 151.8 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain SH3_1 PF00018.26 MSTRG.23103.2_1 - 9e-10 37.9 0.1 4.3e-09 35.7 0.0 2.0 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 MSTRG.23103.2_1 - 1.7e-09 37.1 0.0 3.3e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 MSTRG.23103.2_1 - 3.8e-08 32.9 0.0 7.7e-08 31.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Alpha-amylase_N PF02903.12 MSTRG.23103.2_1 - 0.016 15.2 0.1 0.042 13.9 0.1 1.6 1 0 0 1 1 1 0 Alpha amylase, N-terminal ig-like domain FlaC_arch PF05377.9 MSTRG.23103.2_1 - 0.045 14.0 0.8 0.16 12.2 0.8 2.0 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Flg_hook PF02120.14 MSTRG.23103.2_1 - 0.1 12.4 1.4 0.21 11.4 1.4 1.4 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK DUF3544 PF12064.6 MSTRG.23103.2_1 - 5.3 7.1 9.3 0.1 12.8 1.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3544) ING PF12998.5 MSTRG.25890.1_2 - 8.5e-26 90.4 4.1 1.5e-25 89.5 4.1 1.4 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.27 MSTRG.25890.1_2 - 6.7e-06 25.8 7.6 6.7e-06 25.8 7.6 2.0 2 0 0 2 2 2 1 PHD-finger Ku_N PF03731.13 MSTRG.25890.1_2 - 0.0057 16.3 0.2 0.0086 15.7 0.2 1.2 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain PHD_2 PF13831.4 MSTRG.25890.1_2 - 0.0092 15.4 2.8 0.017 14.5 2.8 1.4 1 0 0 1 1 1 1 PHD-finger SRP-alpha_N PF04086.11 MSTRG.25890.1_2 - 0.015 15.1 2.1 0.023 14.5 2.1 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DivIVA PF05103.11 MSTRG.25890.1_2 - 0.098 12.6 5.1 0.17 11.9 4.7 1.6 1 1 0 1 1 1 0 DivIVA protein zf-HC5HC2H PF13771.4 MSTRG.25890.1_2 - 0.13 12.4 2.2 0.34 11.0 2.2 1.7 1 0 0 1 1 1 0 PHD-like zinc-binding domain PHM7_cyt PF14703.4 MSTRG.25890.1_2 - 0.15 12.1 2.5 0.11 12.7 0.3 1.9 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter zf-RING-like PF08746.9 MSTRG.25890.1_2 - 3.6 7.8 6.8 0.6 10.3 2.3 2.0 2 0 0 2 2 2 0 RING-like domain Biopterin_H PF00351.19 MSTRG.25038.1_3 - 3.8e-172 571.7 0.0 4.8e-172 571.4 0.0 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.23 MSTRG.25038.1_3 - 6.2e-08 32.2 0.1 1.4e-07 31.0 0.1 1.6 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.4 MSTRG.25038.1_3 - 0.095 13.2 0.4 0.22 12.0 0.4 1.5 1 0 0 1 1 1 0 ACT domain DUF262 PF03235.12 MSTRG.25038.1_3 - 0.17 11.9 2.8 0.36 10.8 2.8 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF262 MS_channel PF00924.16 MSTRG.25038.1_3 - 0.17 11.2 0.1 0.32 10.4 0.1 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel SelP_N PF04592.12 MSTRG.15015.1_3 - 0.041 13.1 0.1 0.047 13.0 0.1 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DEAD PF00270.27 MSTRG.19304.1_3 - 4.6e-12 45.9 0.0 5.4e-12 45.7 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.4 MSTRG.19304.1_3 - 0.011 15.9 0.0 0.011 15.9 0.0 1.1 1 0 0 1 1 1 0 AAA domain TniB PF05621.9 MSTRG.19304.1_3 - 0.023 13.7 0.0 0.023 13.7 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein CobA_CobO_BtuR PF02572.13 MSTRG.19304.1_3 - 0.16 12.1 0.0 0.19 11.8 0.0 1.1 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Sulfotransfer_1 PF00685.25 MSTRG.14226.1_3 - 1e-40 139.8 0.0 1.4e-40 139.3 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 MSTRG.14226.1_3 - 1.9e-15 57.7 0.0 2e-09 38.0 0.0 2.2 1 1 1 2 2 2 2 Sulfotransferase family SCAMP PF04144.11 MSTRG.17600.1_2 - 8.9e-71 237.6 19.6 1.4e-70 237.0 19.6 1.3 1 0 0 1 1 1 1 SCAMP family OmpH PF03938.12 MSTRG.17600.1_2 - 0.074 12.9 1.7 0.14 12.0 1.7 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TPR_1 PF00515.26 MSTRG.17600.1_3 - 2.4e-36 121.9 8.1 8e-05 22.2 0.0 8.8 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.17600.1_3 - 4.9e-35 116.7 6.0 0.0024 17.7 0.0 9.2 10 0 0 10 10 9 7 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.17600.1_3 - 1.6e-28 96.4 0.5 0.0067 16.4 0.1 8.0 8 0 0 8 8 7 7 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.17600.1_3 - 2e-25 88.1 1.9 1.3e-05 24.6 0.0 7.5 3 1 5 8 8 8 5 TPR repeat TPR_12 PF13424.4 MSTRG.17600.1_3 - 1.4e-20 73.2 6.3 0.0023 18.0 1.4 6.6 4 2 2 7 7 7 6 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.17600.1_3 - 1.5e-17 63.7 3.0 0.00017 21.9 0.0 4.7 4 2 1 6 6 4 4 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.17600.1_3 - 3.8e-15 55.2 2.6 0.0005 20.5 0.0 6.9 3 3 5 8 8 7 3 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.17600.1_3 - 2.3e-14 53.2 12.8 0.00077 19.5 0.0 4.8 2 1 2 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.4 MSTRG.17600.1_3 - 5.4e-14 51.4 10.0 0.003 17.7 0.0 8.7 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.17600.1_3 - 4.8e-12 46.2 0.0 0.07 13.7 0.1 4.9 3 2 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.17600.1_3 - 7e-12 44.4 2.3 0.1 12.5 0.0 6.5 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_9 PF13371.4 MSTRG.17600.1_3 - 4.1e-09 36.4 0.0 0.0015 18.5 0.0 4.4 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.17600.1_3 - 7.6e-07 29.3 3.2 6.6 7.5 0.0 7.0 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_15 PF13429.4 MSTRG.17600.1_3 - 2.8e-06 26.6 3.3 0.0015 17.7 0.0 3.5 1 1 1 3 3 3 1 Tetratricopeptide repeat NARP1 PF12569.6 MSTRG.17600.1_3 - 2.5e-05 23.3 0.5 0.0075 15.1 0.0 3.1 2 1 1 4 4 4 1 NMDA receptor-regulated protein 1 PknG_TPR PF16918.3 MSTRG.17600.1_3 - 0.00026 19.7 0.3 0.45 9.0 0.0 2.6 2 1 1 3 3 3 2 Protein kinase G tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.17600.1_3 - 0.00036 20.2 10.0 11 6.0 0.6 7.0 7 0 0 7 7 7 0 Tetratricopeptide repeat DUF627 PF04781.10 MSTRG.17600.1_3 - 0.024 14.5 2.5 83 3.1 0.0 4.5 3 1 2 5 5 5 0 Protein of unknown function (DUF627) TPR_20 PF14561.4 MSTRG.17600.1_3 - 0.064 13.5 0.5 1.8 8.8 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat ChAPs PF09295.8 MSTRG.17600.1_3 - 0.17 10.7 0.4 1.6 7.5 0.1 2.2 2 0 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) BTAD PF03704.15 MSTRG.17600.1_3 - 0.18 12.1 3.1 20 5.5 0.1 3.5 4 1 0 4 4 4 0 Bacterial transcriptional activator domain Coatomer_E PF04733.12 MSTRG.17600.1_3 - 0.36 10.1 1.8 6.9 5.9 0.1 2.6 2 1 1 3 3 3 0 Coatomer epsilon subunit MIT PF04212.16 MSTRG.17600.1_3 - 0.69 9.9 3.0 1.7e+02 2.2 0.0 4.5 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain Endosulfine PF04667.15 MSTRG.5507.2_3 - 2.2e-09 37.2 0.7 3.5e-09 36.6 0.7 1.4 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region RGS12_us1 PF16613.3 MSTRG.11917.1_3 - 2.1e-49 166.6 7.7 6.6e-49 165.0 7.7 1.9 1 0 0 1 1 1 1 Unstructured region of RGS12 RBD PF02196.13 MSTRG.11917.1_3 - 1.4e-27 95.5 0.5 7.8e-17 61.0 0.1 2.7 2 0 0 2 2 2 2 Raf-like Ras-binding domain RGS PF00615.17 MSTRG.11917.1_3 - 3.7e-27 94.8 2.6 6.1e-27 94.1 2.6 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain PDZ PF00595.22 MSTRG.11917.1_3 - 2.1e-11 43.8 0.0 3.9e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) GoLoco PF02188.15 MSTRG.11917.1_3 - 8.9e-09 34.5 0.8 1.8e-08 33.6 0.8 1.6 1 0 0 1 1 1 1 GoLoco motif RGS12_usC PF16612.3 MSTRG.11917.1_3 - 3.4e-08 33.9 17.7 3.4e-08 33.9 17.7 3.7 2 1 0 2 2 2 1 C-terminal unstructured region of RGS12 PDZ_2 PF13180.4 MSTRG.11917.1_3 - 0.012 15.8 0.0 0.028 14.6 0.0 1.5 1 0 0 1 1 1 0 PDZ domain TUG-UBL1 PF11470.6 MSTRG.11917.1_3 - 0.1 12.7 0.0 8.2 6.6 0.0 2.6 2 0 0 2 2 2 0 TUG ubiquitin-like domain zf-Di19 PF05605.10 MSTRG.11917.1_3 - 8.9 6.6 7.8 0.24 11.6 0.4 2.2 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Ank_2 PF12796.5 MSTRG.22574.1_1 - 1e-28 99.6 4.4 3.4e-12 46.6 0.2 3.9 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.22574.1_1 - 1.4e-26 92.4 13.2 2.3e-11 43.8 0.1 5.1 3 1 3 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.22574.1_1 - 2.3e-16 59.3 24.3 0.00034 20.8 0.5 7.2 6 1 1 7 7 7 5 Ankyrin repeat Ank_3 PF13606.4 MSTRG.22574.1_1 - 4.8e-16 57.1 7.4 0.0076 16.6 0.1 7.0 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.4 MSTRG.22574.1_1 - 1.6e-15 56.8 16.5 6.2e-08 32.7 0.5 5.4 4 1 1 5 5 5 4 Ankyrin repeats (many copies) CortBP2 PF09727.7 MSTRG.22574.1_2 - 6.4e-41 140.2 31.0 2.1e-34 119.0 0.4 3.3 2 1 1 3 3 3 3 Cortactin-binding protein-2 DUF4795 PF16043.3 MSTRG.22574.1_2 - 0.015 14.8 17.1 0.025 14.1 17.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) CALCOCO1 PF07888.9 MSTRG.22574.1_2 - 0.19 10.1 22.7 0.28 9.6 22.7 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spc7 PF08317.9 MSTRG.22574.1_2 - 1.1 8.0 26.0 1.7 7.3 26.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Exonuc_VII_L PF02601.13 MSTRG.22574.1_2 - 1.3 8.4 16.6 2.6 7.4 16.6 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF3584 PF12128.6 MSTRG.22574.1_2 - 2.6 5.3 22.9 3.7 4.8 22.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_13 PF13166.4 MSTRG.22574.1_2 - 7.5 4.9 13.0 14 4.0 13.0 1.4 1 0 0 1 1 1 0 AAA domain Septin PF00735.16 MSTRG.16968.1_1 - 2.3e-127 423.9 0.5 3.4e-127 423.4 0.5 1.2 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 MSTRG.16968.1_1 - 3.8e-08 33.3 0.0 9.4e-08 32.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 MSTRG.16968.1_1 - 9.1e-07 28.8 0.2 4.7e-05 23.2 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 MSTRG.16968.1_1 - 0.00032 20.2 0.3 0.052 12.9 0.0 2.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AIG1 PF04548.14 MSTRG.16968.1_1 - 0.0015 17.8 0.2 0.0036 16.5 0.0 1.8 2 0 0 2 2 2 1 AIG1 family Ras PF00071.20 MSTRG.16968.1_1 - 0.0098 15.4 1.6 0.021 14.3 0.1 2.2 3 0 0 3 3 3 1 Ras family Dynamin_N PF00350.21 MSTRG.16968.1_1 - 0.011 15.7 1.7 2.2 8.2 0.0 3.0 2 1 1 3 3 3 0 Dynamin family AAA_16 PF13191.4 MSTRG.16968.1_1 - 0.027 14.7 0.3 0.055 13.7 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.4 MSTRG.16968.1_1 - 0.03 14.5 0.3 0.13 12.5 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.4 MSTRG.16968.1_1 - 0.055 13.0 0.1 0.13 11.9 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.25 MSTRG.16968.1_1 - 0.083 13.3 0.0 0.21 12.0 0.0 1.8 1 0 0 1 1 1 0 ABC transporter Roc PF08477.11 MSTRG.16968.1_1 - 0.098 12.8 0.1 0.22 11.7 0.1 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Pkinase_Tyr PF07714.15 MSTRG.23656.4_1 - 1.7e-84 283.0 0.0 2.3e-84 282.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.23656.4_1 - 8.8e-39 133.3 0.0 1.1e-37 129.7 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain F5_F8_type_C PF00754.23 MSTRG.23656.4_1 - 6e-22 78.0 0.0 1.1e-21 77.1 0.0 1.5 1 0 0 1 1 1 1 F5/8 type C domain DUF4834 PF16118.3 MSTRG.23656.4_1 - 0.062 14.1 0.0 0.12 13.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) MARVEL PF01284.21 MSTRG.13703.1_2 - 2.5e-35 121.5 7.2 3.4e-35 121.1 7.2 1.2 1 0 0 1 1 1 1 Membrane-associating domain DUF588 PF04535.10 MSTRG.13703.1_2 - 0.0031 17.2 1.3 0.0054 16.4 1.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF588) DUF3278 PF11683.6 MSTRG.13703.1_2 - 0.019 14.9 0.9 0.031 14.2 0.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3278) ECF_trnsprt PF12822.5 MSTRG.13703.1_2 - 0.056 13.4 0.8 0.43 10.5 0.2 2.0 2 0 0 2 2 2 0 ECF transporter, substrate-specific component Frizzled PF01534.15 MSTRG.13703.1_2 - 1.2 8.0 7.3 8.1 5.3 7.3 2.1 1 1 0 1 1 1 0 Frizzled/Smoothened family membrane region RRM_1 PF00076.20 MSTRG.13520.1_2 - 1.4e-53 178.5 0.0 1.1e-19 69.8 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 MSTRG.13520.1_2 - 2.1e-06 27.6 0.0 0.0099 15.8 0.0 2.8 3 0 0 3 3 3 2 RNA binding motif Limkain-b1 PF11608.6 MSTRG.13520.1_2 - 2.5e-06 27.3 0.1 0.0036 17.2 0.0 2.9 2 1 0 2 2 2 2 Limkain b1 RRM_5 PF13893.4 MSTRG.13520.1_2 - 0.0002 20.8 0.1 2.3 7.7 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNP_M PF11532.6 MSTRG.13520.1_2 - 0.039 14.0 5.1 0.086 12.9 5.1 1.6 1 0 0 1 1 1 0 Heterogeneous nuclear ribonucleoprotein M RRM_occluded PF16842.3 MSTRG.13520.1_2 - 0.11 12.2 0.0 8 6.3 0.0 2.4 2 0 0 2 2 2 0 Occluded RNA-recognition motif Sulfotransfer_1 PF00685.25 MSTRG.10963.1_1 - 4.2e-18 65.7 0.0 5.2e-18 65.4 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 MSTRG.10963.1_1 - 3e-07 30.9 0.1 0.0066 16.7 0.0 2.0 1 1 1 2 2 2 2 Sulfotransferase family Sulfotransfer_2 PF03567.12 MSTRG.10963.1_1 - 0.012 15.4 0.1 0.012 15.4 0.1 1.2 1 0 0 1 1 1 0 Sulfotransferase family Sushi PF00084.18 MSTRG.15289.1_3 - 1.4e-15 57.5 11.1 1.1e-09 38.7 0.6 2.6 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) SRCR PF00530.16 MSTRG.19106.1_3 - 1.9e-61 204.7 19.7 7.6e-31 106.5 4.3 2.5 3 0 0 3 3 3 2 Scavenger receptor cysteine-rich domain Zona_pellucida PF00100.21 MSTRG.19106.1_3 - 1.6e-32 113.1 0.0 2.9e-32 112.3 0.0 1.3 1 0 0 1 1 1 1 Zona pellucida-like domain SRCR_2 PF15494.4 MSTRG.19106.1_3 - 2.1e-12 47.3 3.0 5.8e-05 23.4 0.2 2.6 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain TYW3 PF02676.12 MSTRG.19106.1_3 - 0.00029 20.1 3.3 0.27 10.4 0.2 2.3 2 0 0 2 2 2 2 Methyltransferase TYW3 GUB_WAK_bind PF13947.4 MSTRG.19106.1_3 - 0.0047 17.6 0.1 7.2 7.4 0.0 3.5 3 0 0 3 3 3 1 Wall-associated receptor kinase galacturonan-binding ubiquitin PF00240.21 MSTRG.16904.1_1 - 2.7e-16 58.9 0.0 4.5e-16 58.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 MSTRG.16904.1_1 - 3.9e-05 23.3 0.0 6.1e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 MSTRG.16904.1_1 - 0.035 14.5 0.0 0.056 13.9 0.0 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain TPR_19 PF14559.4 MSTRG.27795.1_3 - 8.6e-15 54.9 11.4 0.00018 21.8 0.3 6.6 5 2 2 7 7 7 5 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.27795.1_3 - 6.1e-11 42.2 22.9 0.00056 19.9 2.6 5.3 4 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.15 MSTRG.27795.1_3 - 1.9e-09 36.8 31.8 0.12 12.4 0.3 8.6 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.27795.1_3 - 3.3e-08 33.5 5.1 0.95 10.3 0.0 7.3 6 2 2 8 8 7 2 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.27795.1_3 - 1.6e-07 31.8 9.1 0.0019 18.7 0.1 6.1 5 2 2 8 8 8 1 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.27795.1_3 - 0.00032 20.5 11.2 6.1 7.2 0.0 6.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_9 PF13371.4 MSTRG.27795.1_3 - 0.0012 18.8 3.8 0.29 11.2 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.27795.1_3 - 0.0079 15.9 23.8 2.3 8.1 0.1 7.0 7 0 0 7 7 7 3 Tetratricopeptide repeat RPN7 PF10602.7 MSTRG.27795.1_3 - 0.038 13.5 4.9 0.79 9.2 0.3 4.0 3 1 0 3 3 3 0 26S proteasome subunit RPN7 TPR_6 PF13174.4 MSTRG.27795.1_3 - 0.067 13.7 20.2 0.48 11.0 0.0 7.4 8 0 0 8 8 8 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 MSTRG.27795.1_3 - 0.068 13.1 11.1 0.23 11.4 0.3 4.4 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.27795.1_3 - 0.079 12.9 9.9 0.16 12.0 0.1 4.9 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.27795.1_3 - 0.27 11.4 17.8 0.29 11.3 0.1 6.0 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.27795.1_3 - 0.68 10.3 3.4 33 5.1 0.0 4.9 5 1 1 6 6 4 0 Tetratricopeptide repeat TPR_3 PF07720.10 MSTRG.27795.1_3 - 0.91 9.5 7.2 4.5 7.2 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.27795.1_3 - 2.4 8.1 9.4 5.6 6.9 0.1 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat Cortexin PF11057.6 MSTRG.4544.1_1 - 0.044 13.5 0.1 0.088 12.5 0.1 1.4 1 0 0 1 1 1 0 Cortexin of kidney Kelch_1 PF01344.23 MSTRG.4544.1_3 - 1.7e-50 168.2 11.9 3.6e-11 42.3 0.0 5.9 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.4 MSTRG.4544.1_3 - 1.3e-30 104.5 7.2 1.6e-05 24.8 0.0 5.9 2 1 4 6 6 6 5 Kelch motif BACK PF07707.13 MSTRG.4544.1_3 - 3.8e-28 97.5 2.8 4.3e-28 97.3 1.1 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.29 MSTRG.4544.1_3 - 4.1e-27 94.5 0.1 8.2e-27 93.5 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain Kelch_4 PF13418.4 MSTRG.4544.1_3 - 5.4e-27 93.4 0.6 4.1e-07 29.7 0.0 5.6 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_2 PF07646.13 MSTRG.4544.1_3 - 1.2e-24 85.2 5.9 0.0002 21.1 0.1 6.0 5 1 0 5 5 5 5 Kelch motif Kelch_3 PF13415.4 MSTRG.4544.1_3 - 4.6e-23 80.8 3.2 0.0012 18.9 0.0 6.2 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.4 MSTRG.4544.1_3 - 6.7e-14 51.4 4.0 1.8e-06 27.7 0.0 5.5 5 0 0 5 5 5 4 Kelch motif DUF3342 PF11822.6 MSTRG.4544.1_3 - 0.0047 17.0 0.0 0.026 14.6 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3342) DUF1668 PF07893.11 MSTRG.4544.1_3 - 0.0077 15.5 0.5 0.017 14.4 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1668) AAA_16 PF13191.4 MSTRG.4077.1_1 - 1.2e-11 45.1 0.7 2.2e-07 31.3 0.1 2.3 1 1 1 2 2 2 2 AAA ATPase domain AAA PF00004.27 MSTRG.4077.1_1 - 1.1e-09 38.6 0.0 1.7e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 MSTRG.4077.1_1 - 5.9e-09 36.2 0.0 1.1e-08 35.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain NACHT PF05729.10 MSTRG.4077.1_1 - 2.7e-07 30.5 0.0 4.8e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_19 PF13245.4 MSTRG.4077.1_1 - 0.0056 16.9 0.0 0.044 14.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.7 MSTRG.4077.1_1 - 0.077 12.1 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Viral_helicase1 PF01443.16 MSTRG.4077.1_1 - 0.16 11.5 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.24 MSTRG.4077.1_1 - 0.17 11.4 0.0 0.39 10.3 0.0 1.4 1 1 0 1 1 1 0 Sigma-54 interaction domain T2SSE PF00437.18 MSTRG.4077.1_1 - 0.22 10.4 0.0 0.32 9.9 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF4714 PF15833.3 MSTRG.537.1_3 - 0.34 10.8 5.6 2.5 7.9 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4714) Myosin_head PF00063.19 MSTRG.28578.1_3 - 9.5e-26 90.1 0.0 1e-25 90.0 0.0 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) DUF2040 PF09745.7 MSTRG.24046.1_3 - 7.2e-37 126.0 24.7 7.2e-37 126.0 24.7 2.7 2 1 1 3 3 3 1 Coiled-coil domain-containing protein 55 (DUF2040) FAM153 PF15722.3 MSTRG.24046.1_3 - 0.015 15.6 0.5 0.015 15.6 0.5 2.5 3 0 0 3 3 3 0 FAM153 family HSP70 PF00012.18 MSTRG.9548.1_2 - 1.3e-192 641.0 12.0 1.3e-191 637.7 5.5 2.4 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.11 MSTRG.9548.1_2 - 5.4e-07 28.6 0.0 9.6e-07 27.8 0.0 1.3 1 0 0 1 1 1 1 MreB/Mbl protein TMEM132D_C PF15706.3 MSTRG.15622.1_2 - 0.1 12.2 0.7 0.15 11.7 0.7 1.2 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF4851 PF16143.3 MSTRG.25480.1_2 - 0.11 11.9 0.0 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4851) CABIT PF12736.5 MSTRG.4584.2_2 - 2.3e-26 92.6 0.0 2.2e-22 79.6 0.0 2.4 2 1 0 2 2 2 2 Cell-cycle sustaining, positive selection, Thymosin PF01290.18 MSTRG.7509.2_1 - 4.6e-31 106.1 34.8 1.3e-11 43.9 8.7 3.3 3 0 0 3 3 3 3 Thymosin beta-4 family DUF4522 PF15022.4 MSTRG.7509.2_1 - 0.048 13.8 11.5 1.6 8.8 1.1 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF4522) DUF4028 PF13220.4 MSTRG.7509.2_1 - 0.33 10.6 10.5 0.71 9.6 0.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4028) DUF5066 PF16728.3 MSTRG.7509.2_1 - 3.5 6.8 5.9 11 5.2 0.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5066) Orthopox_B11R PF07033.9 MSTRG.7509.2_1 - 7.5 6.3 8.0 24 4.7 2.2 2.4 1 1 1 2 2 2 0 Orthopoxvirus B11R protein WH2 PF02205.18 MSTRG.6307.1_2 - 0.00015 21.4 0.0 0.00026 20.6 0.0 1.4 1 0 0 1 1 1 1 WH2 motif VHP PF02209.17 MSTRG.6307.1_2 - 0.72 9.8 2.4 5.3 7.1 0.1 2.6 2 0 0 2 2 2 0 Villin headpiece domain RR_TM4-6 PF06459.10 MSTRG.6307.1_2 - 3.6 7.2 7.6 5.3 6.6 7.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Phostensin_N PF13916.4 MSTRG.6307.1_2 - 6.3 7.1 12.0 24 5.2 0.8 2.6 1 1 1 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal Band_7 PF01145.23 MSTRG.2368.2_3 - 1.1e-29 103.6 5.5 1.6e-29 103.1 4.3 1.8 1 1 0 1 1 1 1 SPFH domain / Band 7 family Band_7_C PF16200.3 MSTRG.2368.2_3 - 5.1e-26 90.4 1.3 1.1e-25 89.3 1.3 1.6 1 0 0 1 1 1 1 C-terminal region of band_7 Band_7_1 PF13421.4 MSTRG.2368.2_3 - 0.11 12.1 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 SPFH domain-Band 7 family EpoR_lig-bind PF09067.8 MSTRG.22240.1_2 - 7.2e-28 96.7 6.8 7e-27 93.5 0.7 2.6 2 0 0 2 2 2 2 Erythropoietin receptor, ligand binding PI3_PI4_kinase PF00454.25 MSTRG.4310.2_1 - 3.6e-46 157.9 0.0 3.6e-46 157.9 0.0 2.2 3 0 0 3 3 3 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.21 MSTRG.4310.2_1 - 1.7e-29 103.0 9.7 2.9e-29 102.3 9.7 1.4 1 0 0 1 1 1 1 FAT domain FATC PF02260.18 MSTRG.4310.2_1 - 1.2e-12 47.3 0.1 3.5e-12 45.8 0.1 1.9 1 0 0 1 1 1 1 FATC domain Trimer_CC PF08954.9 MSTRG.14569.1_3 - 0.0027 17.1 6.1 0.059 12.8 1.0 3.2 2 0 0 2 2 2 2 Trimerisation motif ParBc PF02195.16 MSTRG.14569.1_3 - 0.074 13.2 0.9 0.2 11.8 0.1 2.2 2 0 0 2 2 2 0 ParB-like nuclease domain PRIMA1 PF16101.3 MSTRG.14569.1_3 - 0.59 10.0 9.2 1.3 8.9 9.2 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 T3SSipB PF16535.3 MSTRG.14569.1_3 - 3.7 7.9 22.6 1.6 9.1 5.9 3.0 2 1 1 3 3 3 0 Type III cell invasion protein SipB Pkinase_Tyr PF07714.15 MSTRG.2602.3_1 - 2.8e-99 331.5 0.0 3.7e-99 331.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.2602.3_1 - 1.1e-49 169.0 0.0 1.6e-49 168.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain EphA2_TM PF14575.4 MSTRG.2602.3_1 - 8.7e-23 80.8 0.1 1.8e-22 79.8 0.1 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SAM_1 PF00536.28 MSTRG.2602.3_1 - 7e-22 77.5 0.3 2.5e-21 75.8 0.0 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 MSTRG.2602.3_1 - 2.9e-19 68.8 0.0 5.6e-19 67.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) fn3 PF00041.19 MSTRG.2602.3_1 - 3.5e-15 56.0 1.7 6.5e-15 55.1 0.7 2.0 2 0 0 2 2 2 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 MSTRG.2602.3_1 - 0.00035 21.0 0.9 0.00066 20.1 0.9 1.4 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain SusE PF14292.4 MSTRG.2602.3_1 - 0.02 15.2 0.0 0.041 14.1 0.0 1.4 1 0 0 1 1 1 0 SusE outer membrane protein Kdo PF06293.12 MSTRG.2602.3_1 - 0.12 11.6 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Vezatin PF12632.5 MSTRG.24306.2_2 - 7e-74 248.6 0.0 1e-73 248.0 0.0 1.3 1 0 0 1 1 1 1 Mysoin-binding motif of peroxisomes Peptidase_M24 PF00557.22 MSTRG.24306.2_3 - 3.8e-44 150.7 0.1 5.8e-44 150.2 0.1 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 LYRIC PF15686.3 MSTRG.24306.2_3 - 1.3 8.3 26.9 2.4 7.5 26.9 1.3 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family zf-C2H2 PF00096.24 MSTRG.17557.1_3 - 0.00031 20.9 2.6 0.00054 20.1 2.6 1.4 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.17557.1_3 - 0.0015 18.8 0.7 0.0015 18.8 0.7 2.1 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.17557.1_3 - 0.029 15.1 1.1 0.061 14.0 1.1 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger SGS PF05002.13 MSTRG.12052.2_2 - 1.6e-32 111.4 1.5 3.4e-32 110.3 1.5 1.6 1 0 0 1 1 1 1 SGS domain CS PF04969.14 MSTRG.12052.2_2 - 5.2e-15 56.1 0.2 1.3e-14 54.8 0.1 1.8 2 0 0 2 2 2 1 CS domain TPR_2 PF07719.15 MSTRG.12052.2_2 - 1.6e-05 24.5 0.5 0.067 13.2 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.12052.2_2 - 0.0014 18.2 0.4 0.088 12.5 0.3 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat Med3 PF11593.6 MSTRG.16544.1_2 - 0.011 14.8 2.7 0.011 14.8 2.7 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF3513 PF12026.6 MSTRG.12274.1_1 - 1.8e-72 243.3 0.8 2.7e-72 242.7 0.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3513) Serine_rich PF08824.8 MSTRG.12274.1_1 - 1.1e-51 174.9 0.0 3.1e-51 173.3 0.0 1.8 1 0 0 1 1 1 1 Serine rich protein interaction domain DUF2062 PF09835.7 MSTRG.27589.1_1 - 0.069 12.9 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) BatA PF07584.9 MSTRG.27589.1_1 - 0.096 12.9 0.1 0.22 11.8 0.1 1.5 1 0 0 1 1 1 0 Aerotolerance regulator N-terminal Aminotran_3 PF00202.19 MSTRG.15122.3_1 - 1.2e-18 66.8 0.1 1.6e-18 66.5 0.1 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_3 PF00202.19 MSTRG.15122.3_2 - 7.5e-26 90.6 0.0 9.5e-26 90.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III RRM_1 PF00076.20 MSTRG.17034.1_1 - 2.4e-08 33.6 0.0 3.7e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1891 PF09004.8 MSTRG.17034.1_1 - 0.00043 19.7 0.2 0.00058 19.3 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1891) NLE PF08154.10 MSTRG.17034.1_1 - 0.15 12.4 0.0 0.26 11.7 0.0 1.5 2 0 0 2 2 2 0 NLE (NUC135) domain MCD PF05292.9 MSTRG.22224.1_3 - 4.2e-127 423.9 0.0 5.3e-127 423.6 0.0 1.1 1 0 0 1 1 1 1 Malonyl-CoA decarboxylase (MCD) GvpL_GvpF PF06386.9 MSTRG.22224.1_3 - 0.031 14.1 0.1 0.066 13.0 0.0 1.4 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF PP2C PF00481.19 MSTRG.20810.1_3 - 1.5e-34 119.6 0.0 1e-33 117.0 0.0 2.1 3 0 0 3 3 3 1 Protein phosphatase 2C SapB_1 PF05184.13 MSTRG.7744.2_2 - 2e-39 133.0 30.6 3.6e-12 45.9 3.7 4.8 4 0 0 4 4 4 4 Saposin-like type B, region 1 SapB_2 PF03489.15 MSTRG.7744.2_2 - 1.8e-35 120.6 29.1 7.9e-10 38.6 0.6 5.3 5 0 0 5 5 5 4 Saposin-like type B, region 2 SapA PF02199.13 MSTRG.7744.2_2 - 7.8e-31 105.8 26.4 1.3e-16 60.3 7.7 4.2 4 0 0 4 4 4 2 Saposin A-type domain HD_3 PF13023.4 MSTRG.7744.2_2 - 0.012 15.5 0.1 0.42 10.4 0.1 2.2 2 0 0 2 2 2 0 HD domain DUF4359 PF14271.4 MSTRG.7744.2_2 - 0.02 15.5 3.8 1.8 9.3 0.2 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4359) HGWP PF03578.13 MSTRG.2791.2_2 - 0.033 13.7 0.1 0.081 12.5 0.1 1.6 1 0 0 1 1 1 0 HGWP repeat CCDC85 PF10226.7 MSTRG.2791.2_3 - 2.1e-89 298.2 6.6 3.9e-89 297.3 6.6 1.4 1 0 0 1 1 1 1 CCDC85 family AMH_N PF04709.10 MSTRG.2791.2_3 - 0.024 13.5 0.7 0.038 12.8 0.7 1.2 1 0 0 1 1 1 0 Anti-Mullerian hormone, N terminal region DUF4577 PF15145.4 MSTRG.2791.2_3 - 0.073 13.0 0.6 0.15 12.0 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4577) ZapB PF06005.10 MSTRG.2791.2_3 - 0.61 10.4 8.2 0.67 10.3 0.7 3.2 3 0 0 3 3 3 0 Cell division protein ZapB TSC22 PF01166.16 MSTRG.2791.2_3 - 1.5 9.1 9.5 5.9 7.1 0.3 3.3 3 0 0 3 3 3 0 TSC-22/dip/bun family K-box PF01486.15 MSTRG.2791.2_3 - 1.6 8.8 19.6 4.2 7.5 10.0 3.9 3 1 0 3 3 3 0 K-box region DUF972 PF06156.11 MSTRG.2791.2_3 - 6.8 7.3 11.2 2.4 8.7 1.5 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF972) Mod_r PF07200.11 MSTRG.2791.2_3 - 8.7 6.3 12.7 0.21 11.6 1.9 2.5 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Sec23_trunk PF04811.13 MSTRG.931.3_3 - 1.9e-84 282.9 0.2 2.9e-84 282.3 0.2 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.10 MSTRG.931.3_3 - 3.1e-21 75.8 0.0 7.6e-21 74.5 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.13 MSTRG.931.3_3 - 9.7e-15 54.2 4.5 1.9e-14 53.3 4.5 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_helical PF04815.13 MSTRG.931.3_3 - 1.9e-13 50.0 0.6 3.9e-13 49.0 0.6 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sen15 PF09631.8 MSTRG.931.3_3 - 0.14 12.3 0.0 0.33 11.1 0.0 1.5 1 0 0 1 1 1 0 Sen15 protein UCR_6-4kD PF08997.8 MSTRG.24935.1_2 - 1.1e-28 98.7 2.6 1.7e-28 98.2 2.6 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex, 6.4kD protein QCR10 PF09796.7 MSTRG.24935.1_2 - 0.0025 17.7 1.7 0.0082 16.0 1.7 1.9 1 1 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) LIM_bind PF01803.14 MSTRG.17868.1_2 - 7.6e-54 182.7 3.7 2.4e-51 174.5 3.7 2.5 1 1 0 1 1 1 1 LIM-domain binding protein F-box-like PF12937.5 MSTRG.7661.2_3 - 4.3e-10 39.2 1.2 8.5e-10 38.2 1.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 MSTRG.7661.2_3 - 4.6e-08 32.6 0.6 7.9e-08 31.9 0.6 1.4 1 0 0 1 1 1 1 F-box domain MIT PF04212.16 MSTRG.7661.2_3 - 0.0027 17.6 0.5 0.0055 16.6 0.5 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain TPR_7 PF13176.4 MSTRG.7661.2_3 - 0.033 14.1 2.4 2.4 8.2 0.1 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.7661.2_3 - 0.042 13.8 0.9 0.15 12.1 0.7 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.7661.2_3 - 0.1 12.4 0.4 0.22 11.2 0.4 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat CBM_21 PF03370.11 MSTRG.9072.2_2 - 1.4e-31 108.9 0.0 2.1e-31 108.3 0.0 1.3 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.3 MSTRG.9072.2_2 - 3.2e-12 46.7 0.5 6.7e-12 45.7 0.1 1.8 2 0 0 2 2 2 1 Starch/carbohydrate-binding module (family 53) DUF4477 PF14780.4 MSTRG.3743.1_3 - 9.7e-54 181.8 4.5 9.7e-54 181.8 4.5 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4477) DSPc PF00782.18 MSTRG.3065.2_1 - 9.1e-26 90.1 0.1 1.6e-25 89.3 0.1 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 MSTRG.3065.2_1 - 0.048 13.1 0.0 0.077 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Neuropep_like PF15161.4 MSTRG.3065.2_1 - 0.1 12.1 0.4 0.51 9.9 0.0 2.2 2 0 0 2 2 2 0 Neuropeptide-like Trypsin PF00089.24 MSTRG.20966.1_1 - 2.5e-28 99.3 0.4 3.9e-28 98.7 0.4 1.2 1 0 0 1 1 1 1 Trypsin Voltage_CLC PF00654.18 MSTRG.4027.1_3 - 6.1e-98 328.2 20.4 6.1e-98 328.2 20.4 1.9 1 1 1 2 2 2 1 Voltage gated chloride channel CBS PF00571.26 MSTRG.4027.1_3 - 1.9e-17 63.3 0.2 5.6e-10 39.4 0.0 2.5 2 0 0 2 2 2 2 CBS domain SM-ATX PF14438.4 MSTRG.1937.2_2 - 4.3e-21 74.7 0.0 9.4e-21 73.6 0.0 1.6 1 0 0 1 1 1 1 Ataxin 2 SM domain LsmAD PF06741.11 MSTRG.1937.2_2 - 1.1e-14 54.6 2.5 2.7e-14 53.4 2.5 1.7 1 0 0 1 1 1 1 LsmAD domain PAM2 PF07145.13 MSTRG.1937.2_2 - 7.4e-06 25.2 1.3 1.9e-05 23.9 1.3 1.8 1 0 0 1 1 1 1 Ataxin-2 C-terminal region Aldolase_II PF00596.19 MSTRG.16590.1_2 - 6.5e-25 88.0 0.2 9.8e-25 87.4 0.2 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Methyltr_RsmB-F PF01189.15 MSTRG.9336.1_1 - 2e-29 102.5 0.0 3.2e-29 101.9 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.17 MSTRG.9336.1_1 - 0.0018 18.3 0.0 0.0037 17.3 0.0 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase MIP-T3 PF10243.7 MSTRG.9336.1_2 - 1.4 7.4 3.7 2.1 6.8 3.7 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 N2227 PF07942.10 MSTRG.2871.1_1 - 9.2e-112 372.5 0.1 1.2e-111 372.2 0.1 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_11 PF08241.10 MSTRG.2871.1_1 - 0.005 17.3 0.0 0.016 15.7 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.15 MSTRG.2871.1_1 - 0.013 14.6 0.0 0.022 13.8 0.0 1.4 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family Methyltransf_12 PF08242.10 MSTRG.2871.1_1 - 0.018 15.6 0.0 0.058 14.0 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.4 MSTRG.2871.1_1 - 0.033 15.1 0.1 0.12 13.3 0.0 2.0 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_23 PF13489.4 MSTRG.2871.1_1 - 0.069 12.9 0.0 0.2 11.4 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain RhoGAP PF00620.25 MSTRG.2871.1_1 - 0.12 12.1 1.8 0.55 9.9 0.3 2.4 2 1 1 3 3 3 0 RhoGAP domain DEAD PF00270.27 MSTRG.11587.2_1 - 4.4e-50 169.7 0.0 2e-49 167.6 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.11587.2_1 - 1.2e-30 106.0 0.0 2.2e-30 105.1 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain UTP25 PF06862.10 MSTRG.11587.2_1 - 0.16 10.6 0.0 0.31 9.6 0.0 1.4 1 0 0 1 1 1 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Actin_micro PF17003.3 MSTRG.115.1_3 - 0.26 10.3 20.2 2.7 7.0 0.0 5.1 4 2 0 4 4 4 0 Putative actin-like family zf-C2H2_2 PF12756.5 MSTRG.115.1_3 - 0.32 11.2 41.1 2.2 8.5 4.7 7.5 5 2 1 6 6 6 0 C2H2 type zinc-finger (2 copies) zf-C2HC_2 PF13913.4 MSTRG.115.1_3 - 2.2 8.2 8.4 14 5.5 1.1 3.8 3 0 0 3 3 3 0 zinc-finger of a C2HC-type Pyridoxal_deC PF00282.17 MSTRG.14729.1_3 - 2.3e-17 62.6 0.0 3.9e-17 61.9 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.17 MSTRG.14729.1_3 - 2.4e-09 36.5 0.0 4e-09 35.8 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.15 MSTRG.14729.1_3 - 0.00035 19.9 0.0 0.00051 19.3 0.0 1.1 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family HAP1_N PF04849.11 MSTRG.16955.1_2 - 3.4 6.7 70.8 0.01 14.9 47.3 2.4 2 0 0 2 2 2 0 HAP1 N-terminal conserved region DUF1664 PF07889.10 MSTRG.16955.1_2 - 6.7 6.6 41.2 0.16 11.8 6.1 4.5 2 2 3 5 5 5 0 Protein of unknown function (DUF1664) Med13_C PF06333.10 MSTRG.10030.1_1 - 1.4e-143 478.8 0.1 1.4e-143 478.8 0.1 2.9 4 0 0 4 4 4 1 Mediator complex subunit 13 C-terminal Med13_N PF11597.6 MSTRG.10030.1_1 - 1.5e-102 343.4 0.1 1.5e-102 343.4 0.1 1.8 2 0 0 2 2 2 1 Mediator complex subunit 13 N-terminal HSP20 PF00011.19 MSTRG.22814.1_1 - 1.1e-24 86.4 0.1 1.9e-24 85.6 0.1 1.4 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Crystallin PF00525.16 MSTRG.22814.1_1 - 0.0013 18.7 0.2 0.0027 17.8 0.2 1.5 1 0 0 1 1 1 1 Alpha crystallin A chain, N terminal YabP PF07873.9 MSTRG.22814.1_1 - 0.0086 15.7 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 YabP family GvpO PF05800.9 MSTRG.22814.1_1 - 0.16 11.9 0.1 0.37 10.7 0.0 1.6 1 1 0 1 1 1 0 Gas vesicle synthesis protein GvpO Glycos_transf_2 PF00535.24 MSTRG.6313.3_2 - 3.9e-34 117.8 0.0 5.6e-34 117.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.20 MSTRG.6313.3_2 - 1.1e-09 38.4 3.2 3.6e-09 36.8 3.2 1.8 1 1 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.12 MSTRG.6313.3_2 - 0.0002 20.8 0.0 0.00043 19.7 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 MSTRG.6313.3_2 - 0.03 13.7 0.0 0.095 12.0 0.0 1.8 1 1 0 1 1 1 0 Glycosyltransferase like family 2 Helicase_C PF00271.29 MSTRG.11375.1_3 - 3.4e-08 33.7 0.0 6.2e-05 23.2 0.0 2.2 2 0 0 2 2 2 2 Helicase conserved C-terminal domain zf-C2H2_jaz PF12171.6 MSTRG.26273.6_2 - 0.34 11.2 12.9 0.14 12.4 2.2 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding TrbC PF04956.11 MSTRG.18743.1_3 - 0.12 12.5 0.1 0.2 11.8 0.1 1.3 1 0 0 1 1 1 0 TrbC/VIRB2 family rRNA_processing PF08524.9 MSTRG.15321.2_2 - 6.6e-12 45.6 46.0 2.3e-11 43.8 24.4 2.3 1 1 1 2 2 2 2 rRNA processing RRM_5 PF13893.4 MSTRG.19847.4_2 - 4e-53 178.2 2.9 9.7e-39 131.7 0.0 3.9 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.20 MSTRG.19847.4_2 - 1.3e-28 98.5 2.6 2.1e-08 33.7 0.1 4.7 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 MSTRG.19847.4_2 - 2.7e-06 27.0 0.2 0.14 11.9 0.0 4.0 4 0 0 4 4 4 2 Occluded RNA-recognition motif p25-alpha PF05517.10 MSTRG.9567.1_3 - 1.6e-60 203.7 4.3 2.7e-60 202.9 4.3 1.4 1 0 0 1 1 1 1 p25-alpha SNF PF00209.16 MSTRG.21053.1_3 - 9e-229 760.3 39.4 1.4e-228 759.8 39.4 1.3 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family RRM_1 PF00076.20 MSTRG.14289.1_2 - 2.1e-34 117.0 0.0 1.9e-16 59.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.9 MSTRG.14289.1_2 - 0.0034 17.2 0.0 0.59 10.1 0.0 2.7 2 1 0 2 2 2 1 RNA binding domain Nup35_RRM_2 PF14605.4 MSTRG.14289.1_2 - 0.014 15.3 0.0 0.54 10.1 0.0 2.7 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Peripla_BP_4 PF13407.4 MSTRG.14289.1_2 - 0.13 11.7 0.1 0.13 11.7 0.1 2.8 3 0 0 3 3 3 0 Periplasmic binding protein domain fn3 PF00041.19 MSTRG.22126.1_1 - 1.2e-87 288.2 58.9 8.4e-11 41.9 1.7 15.9 15 1 0 15 15 15 14 Fibronectin type III domain Y_phosphatase PF00102.25 MSTRG.22126.1_1 - 4.1e-79 265.3 2.6 1.2e-78 263.7 2.1 2.1 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Interfer-bind PF09294.8 MSTRG.22126.1_1 - 4.9e-12 46.0 27.1 0.0017 18.5 0.2 9.7 10 1 1 11 11 11 4 Interferon-alpha/beta receptor, fibronectin type III Y_phosphatase3 PF13350.4 MSTRG.22126.1_1 - 0.00017 21.5 0.0 0.00052 19.9 0.0 1.8 1 0 0 1 1 1 1 Tyrosine phosphatase family DUF2369 PF10179.7 MSTRG.22126.1_1 - 0.00056 20.2 22.3 2.3 8.6 0.2 8.1 8 1 1 9 9 9 3 Uncharacterised conserved protein (DUF2369) Pur_ac_phosph_N PF16656.3 MSTRG.22126.1_1 - 0.0016 18.9 65.1 0.8 10.2 1.1 12.4 8 3 1 9 9 9 4 Purple acid Phosphatase, N-terminal domain DSPc PF00782.18 MSTRG.22126.1_1 - 0.0032 17.1 0.0 0.015 15.0 0.0 2.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 MSTRG.22126.1_1 - 0.0048 16.9 0.1 0.017 15.1 0.1 2.0 1 0 0 1 1 1 1 Inositol hexakisphosphate LRR_8 PF13855.4 MSTRG.5170.2_1 - 1.9e-21 75.5 20.1 1.4e-13 50.3 5.6 2.2 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.31 MSTRG.5170.2_1 - 1.6e-05 24.6 2.9 0.8 10.3 0.1 4.6 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_4 PF12799.5 MSTRG.5170.2_1 - 1.6e-05 25.0 6.3 0.0034 17.6 1.0 2.8 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 MSTRG.5170.2_1 - 0.005 16.7 0.0 0.0072 16.2 0.0 1.1 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_9 PF14580.4 MSTRG.5170.2_1 - 0.0059 16.0 0.4 0.0086 15.5 0.4 1.1 1 0 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.4 MSTRG.5170.2_1 - 1.7 8.7 9.2 11 6.3 0.5 3.9 4 0 0 4 4 4 0 Leucine Rich repeat LRR_8 PF13855.4 MSTRG.5170.2_2 - 4.2e-25 87.2 15.7 6.5e-14 51.3 5.8 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.5 MSTRG.5170.2_2 - 1.2e-07 31.7 3.7 0.0045 17.2 0.4 2.4 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 MSTRG.5170.2_2 - 4.3e-05 22.9 0.4 6.3e-05 22.4 0.4 1.1 1 0 0 1 1 1 1 Leucine-rich repeat LRR_5 PF13306.4 MSTRG.5170.2_2 - 0.00033 20.5 0.0 0.00049 19.9 0.0 1.2 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_1 PF00560.31 MSTRG.5170.2_2 - 6.8 7.5 8.8 75 4.3 0.0 4.6 6 0 0 6 6 6 0 Leucine Rich Repeat RRM_1 PF00076.20 MSTRG.11318.1_3 - 6.6e-15 54.6 0.0 9.7e-15 54.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RING_2 PF13639.4 MSTRG.3863.2_1 - 5.9e-13 48.7 8.5 5.9e-13 48.7 8.5 3.2 4 0 0 4 4 2 1 Ring finger domain zf-RING_11 PF17123.3 MSTRG.3863.2_1 - 2.7e-11 42.8 4.2 2.7e-11 42.8 4.2 3.1 3 0 0 3 3 3 1 RING-like zinc finger PA PF02225.20 MSTRG.3863.2_1 - 9.5e-09 35.1 0.0 2e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 PA domain zf-C3HC4 PF00097.23 MSTRG.3863.2_1 - 2.2e-07 30.5 8.9 2.2e-07 30.5 8.9 2.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 MSTRG.3863.2_1 - 2.9e-07 30.1 9.1 2.9e-07 30.1 9.1 2.1 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 MSTRG.3863.2_1 - 1.4e-05 24.8 7.6 1.4e-05 24.8 7.6 2.9 3 0 0 3 3 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 MSTRG.3863.2_1 - 2.8e-05 23.7 6.6 2.8e-05 23.7 6.6 3.1 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 MSTRG.3863.2_1 - 3.8e-05 23.8 13.0 5e-05 23.4 10.5 2.5 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.4 MSTRG.3863.2_1 - 0.00012 21.9 2.4 0.00012 21.9 2.4 3.0 2 1 1 3 3 2 1 RING-type zinc-finger Prok-RING_4 PF14447.4 MSTRG.3863.2_1 - 0.0009 18.9 7.2 0.0009 18.9 7.2 2.3 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.5 MSTRG.3863.2_1 - 0.0033 17.3 5.6 0.011 15.6 5.6 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger EphA2_TM PF14575.4 MSTRG.3863.2_1 - 0.056 14.1 0.0 0.19 12.4 0.0 2.0 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Baculo_11_kDa PF06143.9 MSTRG.3863.2_1 - 0.22 11.0 3.9 0.075 12.5 0.5 1.9 2 0 0 2 2 2 0 Baculovirus 11 kDa family zf-C2H2 PF00096.24 MSTRG.18267.1_3 - 3.6e-10 39.6 25.5 0.00096 19.3 0.3 4.8 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.18267.1_3 - 1.1e-09 38.1 5.9 2e-07 31.0 0.6 4.8 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.18267.1_3 - 3.7e-05 24.0 28.5 0.015 16.0 2.1 4.8 4 0 0 4 4 4 3 C2H2-type zinc finger FOXP-CC PF16159.3 MSTRG.18267.1_3 - 0.0015 18.9 7.0 0.81 10.2 0.2 3.2 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-met PF12874.5 MSTRG.18267.1_3 - 0.0087 16.3 9.5 0.58 10.5 1.3 3.6 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.18267.1_3 - 0.21 11.8 5.0 4.2 7.7 0.6 3.1 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Laminin_B PF00052.16 MSTRG.10422.1_1 - 1.4e-28 99.4 0.0 2.2e-28 98.7 0.0 1.3 1 0 0 1 1 1 1 Laminin B (Domain IV) Laminin_EGF PF00053.22 MSTRG.10422.1_1 - 5e-12 45.6 69.3 1.9e-07 31.0 13.3 5.2 5 0 0 5 5 5 3 Laminin EGF domain Paf1 PF03985.11 MSTRG.10088.1_2 - 1e-146 489.1 14.8 1e-146 489.1 14.8 2.2 1 1 1 2 2 2 1 Paf1 BNIP3 PF06553.10 MSTRG.26517.1_1 - 1.1e-67 227.4 3.8 1.4e-67 227.1 3.8 1.1 1 0 0 1 1 1 1 BNIP3 Pro_isomerase PF00160.19 MSTRG.9795.1_3 - 1.4e-51 174.7 0.5 1.8e-51 174.4 0.5 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RAI16-like PF10257.7 MSTRG.27548.1_3 - 0.034 12.9 0.2 0.05 12.3 0.2 1.3 1 0 0 1 1 1 0 Retinoic acid induced 16-like protein zf-H2C2_2 PF13465.4 MSTRG.16129.1_3 - 3.3e-70 229.5 80.0 4.1e-10 39.5 0.9 12.0 12 0 0 12 12 12 11 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.16129.1_3 - 1.2e-50 167.0 94.2 1.6e-05 25.0 3.0 11.7 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.16129.1_3 - 1.6e-37 124.8 83.9 0.00025 21.5 2.4 11.8 11 0 0 11 11 11 11 C2H2-type zinc finger zf-met PF12874.5 MSTRG.16129.1_3 - 4.1e-25 87.3 72.3 0.00092 19.4 0.4 11.5 11 0 0 11 11 11 11 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.16129.1_3 - 9.3e-13 48.0 43.6 0.14 12.4 1.6 11.4 11 0 0 11 11 11 6 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 MSTRG.16129.1_3 - 1.3e-09 38.1 48.4 0.00047 20.3 1.8 7.6 2 2 6 9 9 9 8 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.4 MSTRG.16129.1_3 - 2.2e-07 30.5 73.0 0.13 12.1 0.7 12.5 11 2 0 11 11 10 6 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 MSTRG.16129.1_3 - 0.0014 19.2 39.2 0.088 13.4 1.1 6.8 3 2 5 8 8 7 4 zinc-ribbon family zf-H2C2_5 PF13909.4 MSTRG.16129.1_3 - 0.0071 15.9 0.5 0.0071 15.9 0.5 10.2 11 0 0 11 11 11 3 C2H2-type zinc-finger domain LIM PF00412.20 MSTRG.16129.1_3 - 0.0079 16.3 55.5 0.94 9.6 1.6 9.6 3 3 7 10 10 10 6 LIM domain Chordopox_RPO7 PF05864.10 MSTRG.16129.1_3 - 0.033 14.3 12.1 18 5.5 0.0 6.5 6 1 1 7 7 7 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) BolA PF01722.16 MSTRG.16129.1_3 - 0.25 11.5 22.5 3.3 7.9 0.2 6.5 4 3 1 5 5 5 0 BolA-like protein zf-C4_ClpX PF06689.11 MSTRG.16129.1_3 - 0.89 9.4 0.0 0.89 9.4 0.0 9.8 11 0 0 11 11 11 0 ClpX C4-type zinc finger C1_2 PF03107.14 MSTRG.16129.1_3 - 1.7 8.9 56.2 5.1 7.4 0.2 10.7 1 1 7 8 8 8 0 C1 domain DUF968 PF06147.9 MSTRG.16129.1_3 - 8.8 6.4 18.9 0.19 11.9 1.3 4.0 2 1 3 5 5 5 0 Protein of unknown function (DUF968) zf-LYAR PF08790.9 MSTRG.16129.1_3 - 8.9 6.2 46.7 13 5.6 0.4 10.4 10 0 0 10 10 10 0 LYAR-type C2HC zinc finger eIF-3_zeta PF05091.10 MSTRG.19469.2_2 - 2e-214 713.3 6.7 2.3e-214 713.1 6.7 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NARG2_C PF10505.7 MSTRG.19469.2_2 - 0.00018 21.0 0.0 0.0022 17.5 0.0 2.2 1 1 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus CENP-B_dimeris PF09026.8 MSTRG.19469.2_2 - 0.54 10.6 7.8 1.4 9.2 7.8 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RED_C PF07807.9 MSTRG.28982.1_2 - 2.4 8.5 8.2 28 5.1 5.4 2.3 1 1 1 2 2 2 0 RED-like protein C-terminal region DUF2714 PF10896.6 MSTRG.22881.1_3 - 0.0058 16.6 6.1 1.1 9.1 0.1 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF2714) Dimerisation PF08100.9 MSTRG.22881.1_3 - 0.039 13.9 0.0 0.2 11.6 0.0 2.3 1 0 0 1 1 1 0 Dimerisation domain BCL9 PF11502.6 MSTRG.22881.1_3 - 0.07 12.8 0.3 0.21 11.3 0.3 1.8 1 0 0 1 1 1 0 B-cell lymphoma 9 protein Med11 PF10280.7 MSTRG.22881.1_3 - 0.1 13.0 0.9 0.8 10.0 0.0 3.0 3 0 0 3 3 3 0 Mediator complex protein Phage_min_cap2 PF06152.9 MSTRG.22881.1_3 - 0.19 10.5 0.4 0.8 8.4 0.0 2.1 2 0 0 2 2 2 0 Phage minor capsid protein 2 RRM_1 PF00076.20 MSTRG.2562.3_2 - 1.4e-16 59.9 0.0 2.3e-16 59.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.2562.3_2 - 0.002 18.0 0.0 0.0043 17.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif Limkain-b1 PF11608.6 MSTRG.2562.3_2 - 0.0045 16.9 0.0 0.0094 15.9 0.0 1.4 1 0 0 1 1 1 1 Limkain b1 RRM_3 PF08777.9 MSTRG.2562.3_2 - 0.02 14.8 0.0 0.047 13.6 0.0 1.6 1 0 0 1 1 1 0 RNA binding motif RRM_occluded PF16842.3 MSTRG.2562.3_2 - 0.041 13.6 0.0 0.069 12.9 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif RRM_5 PF13893.4 MSTRG.2562.3_2 - 0.083 12.4 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 MSTRG.2562.3_2 - 0.11 12.3 0.1 0.23 11.3 0.1 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RAP1 PF07218.9 MSTRG.2562.3_2 - 1.2 7.2 8.5 1.5 6.9 8.5 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) GST_N PF02798.18 MSTRG.4702.1_1 - 7.7e-13 48.5 0.0 1.5e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.4 MSTRG.4702.1_1 - 1e-11 44.9 0.0 1.7e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 MSTRG.4702.1_1 - 3.7e-10 39.9 0.0 6.3e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.4 MSTRG.4702.1_1 - 2e-06 27.8 0.0 3.4e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 MSTRG.4702.1_1 - 2.7e-06 27.4 0.0 4.7e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 MSTRG.4702.1_1 - 0.0008 19.2 0.0 0.003 17.3 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Peptidase_C14 PF00656.20 MSTRG.27644.1_1 - 5.8e-47 160.6 0.0 8.2e-47 160.1 0.0 1.2 1 0 0 1 1 1 1 Caspase domain NUDE_C PF04880.11 MSTRG.16298.1_3 - 3.3e-25 89.5 2.6 3.3e-25 89.5 2.6 2.5 2 1 0 2 2 1 1 NUDE protein, C-terminal conserved region ATG16 PF08614.9 MSTRG.16298.1_3 - 1.4e-05 25.2 33.8 0.0061 16.6 9.6 2.1 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) Golgin_A5 PF09787.7 MSTRG.16298.1_3 - 0.0011 18.4 24.9 0.0015 17.9 24.9 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 5 DUF4686 PF15742.3 MSTRG.16298.1_3 - 0.0043 16.1 21.3 0.0043 16.1 21.3 1.8 1 1 0 2 2 2 1 Domain of unknown function (DUF4686) KxDL PF10241.7 MSTRG.16298.1_3 - 0.014 15.5 5.3 0.014 15.5 5.3 2.6 2 1 0 2 2 2 0 Uncharacterized conserved protein Cor1 PF04803.10 MSTRG.16298.1_3 - 0.016 15.3 14.1 0.036 14.2 14.1 1.6 1 0 0 1 1 1 0 Cor1/Xlr/Xmr conserved region tRNA-synt_1d PF00750.17 MSTRG.16298.1_3 - 0.045 12.6 4.2 0.046 12.5 3.5 1.3 1 1 0 1 1 1 0 tRNA synthetases class I (R) GAS PF13851.4 MSTRG.16298.1_3 - 0.074 12.3 28.7 0.044 13.0 21.7 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding PRKG1_interact PF15898.3 MSTRG.16298.1_3 - 0.083 13.7 25.0 0.24 12.2 8.8 2.6 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain TPR_MLP1_2 PF07926.10 MSTRG.16298.1_3 - 0.093 12.7 33.4 0.13 12.2 12.1 3.3 1 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein ERM PF00769.17 MSTRG.16298.1_3 - 0.1 12.3 32.2 0.83 9.3 16.0 2.7 1 1 1 2 2 2 0 Ezrin/radixin/moesin family FlaC_arch PF05377.9 MSTRG.16298.1_3 - 0.14 12.5 12.3 0.099 12.9 1.2 3.5 3 1 1 4 4 3 0 Flagella accessory protein C (FlaC) DUF3584 PF12128.6 MSTRG.16298.1_3 - 0.15 9.4 23.2 0.21 8.9 23.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) FAD-SLDH PF12318.6 MSTRG.16298.1_3 - 0.2 11.6 2.6 0.31 11.0 2.6 1.4 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase Reo_sigmaC PF04582.10 MSTRG.16298.1_3 - 0.2 10.9 4.2 0.93 8.7 1.0 2.0 1 1 1 2 2 2 0 Reovirus sigma C capsid protein DUF972 PF06156.11 MSTRG.16298.1_3 - 0.22 12.1 19.8 0.4 11.2 8.3 3.3 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Filament PF00038.19 MSTRG.16298.1_3 - 0.26 10.7 26.5 0.044 13.2 14.0 2.4 1 1 1 2 2 2 0 Intermediate filament protein CENP-F_leu_zip PF10473.7 MSTRG.16298.1_3 - 0.43 10.5 31.4 3.4 7.5 28.7 2.6 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 RmuC PF02646.14 MSTRG.16298.1_3 - 0.52 9.3 17.4 0.092 11.7 8.7 2.4 1 1 2 3 3 3 0 RmuC family DUF1759 PF03564.13 MSTRG.16298.1_3 - 0.58 9.9 6.3 1.1 9.1 2.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1759) CCDC92 PF14916.4 MSTRG.16298.1_3 - 0.59 9.8 13.7 2.8 7.7 0.0 3.8 3 1 0 3 3 3 0 Coiled-coil domain of unknown function HMMR_N PF15905.3 MSTRG.16298.1_3 - 1 8.6 27.3 1.5 8.1 13.4 2.0 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal IncA PF04156.12 MSTRG.16298.1_3 - 1.3 8.7 37.6 2.7 7.6 17.3 2.2 1 1 1 2 2 2 0 IncA protein HAP1_N PF04849.11 MSTRG.16298.1_3 - 1.3 8.0 30.6 18 4.3 29.8 2.5 1 1 1 2 2 2 0 HAP1 N-terminal conserved region DUF1664 PF07889.10 MSTRG.16298.1_3 - 1.4 8.8 11.8 0.48 10.3 5.7 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) CC2-LZ PF16516.3 MSTRG.16298.1_3 - 1.4 9.1 24.9 0.14 12.3 17.0 2.6 2 1 1 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF2913 PF11140.6 MSTRG.16298.1_3 - 1.8 8.0 9.7 4.4 6.7 9.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2913) Syntaxin-6_N PF09177.9 MSTRG.16298.1_3 - 2.1 8.8 17.4 12 6.4 6.5 3.0 1 1 2 3 3 3 0 Syntaxin 6, N-terminal Baculo_PEP_C PF04513.10 MSTRG.16298.1_3 - 3.9 7.4 6.4 79 3.1 6.1 2.3 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Prominin PF05478.9 MSTRG.16298.1_3 - 4.1 5.1 12.4 0.67 7.7 5.3 2.0 1 1 2 3 3 3 0 Prominin BST2 PF16716.3 MSTRG.16298.1_3 - 4.3 7.8 27.7 0.58 10.6 11.5 3.3 1 1 2 3 3 3 0 Bone marrow stromal antigen 2 DUF4407 PF14362.4 MSTRG.16298.1_3 - 4.6 6.4 19.1 8 5.6 18.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) APG6 PF04111.10 MSTRG.16298.1_3 - 4.8 6.3 30.4 0.98 8.6 22.1 2.1 1 1 1 2 2 2 0 Autophagy protein Apg6 DUF4337 PF14235.4 MSTRG.16298.1_3 - 5 7.1 19.9 38 4.2 17.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) Rootletin PF15035.4 MSTRG.16298.1_3 - 5.9 6.8 32.1 8.6 6.2 10.3 2.2 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF3450 PF11932.6 MSTRG.16298.1_3 - 6.1 5.9 27.0 3.7 6.6 13.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) V-ATPase_G_2 PF16999.3 MSTRG.16298.1_3 - 7.5 6.9 22.4 2.6 8.4 17.1 2.6 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit Laminin_II PF06009.10 MSTRG.16298.1_3 - 7.8 6.4 15.8 1.5 8.7 4.8 2.2 1 1 1 2 2 2 0 Laminin Domain II bZIP_1 PF00170.19 MSTRG.16298.1_3 - 7.8 6.5 22.6 0.064 13.2 4.2 4.1 2 2 3 5 5 5 0 bZIP transcription factor Fib_alpha PF08702.8 MSTRG.16298.1_3 - 8.6 6.4 15.2 5 7.2 4.8 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Spc7 PF08317.9 MSTRG.16298.1_3 - 9.1 4.9 29.9 2.7 6.6 14.2 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein HALZ PF02183.16 MSTRG.16298.1_3 - 9.2 6.4 18.9 0.21 11.7 3.6 3.5 3 0 0 3 3 3 0 Homeobox associated leucine zipper DUF4446 PF14584.4 MSTRG.16298.1_3 - 9.8 6.0 12.1 1.7 8.4 4.3 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF4446) Ric8 PF10165.7 MSTRG.15509.1_1 - 4.8e-31 108.2 0.0 5.6e-31 107.9 0.0 1.0 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn DDE_1 PF03184.17 MSTRG.7094.1_2 - 2.3e-06 27.2 0.1 2.6e-06 27.0 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease zf-Mss51 PF13824.4 MSTRG.7094.1_2 - 3.5 7.7 5.0 3.1 7.9 0.7 2.5 2 1 0 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-C2H2_2 PF12756.5 MSTRG.25468.4_1 - 7.4e-41 138.5 23.6 2.1e-22 79.2 5.4 3.6 4 0 0 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.4 MSTRG.25468.4_1 - 3.7e-06 27.2 30.0 0.0017 18.9 0.4 6.3 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.25468.4_1 - 0.00031 20.8 2.2 0.00031 20.8 2.2 4.1 5 1 0 5 5 5 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.24 MSTRG.25468.4_1 - 0.00031 20.9 1.2 0.00031 20.9 1.2 5.1 5 0 0 5 5 5 1 Zinc finger, C2H2 type zf-BED PF02892.13 MSTRG.25468.4_1 - 0.016 15.1 4.7 0.054 13.4 0.8 5.2 6 0 0 6 6 6 0 BED zinc finger zf-met PF12874.5 MSTRG.25468.4_1 - 0.032 14.5 1.2 0.032 14.5 1.2 2.9 2 0 0 2 2 2 0 Zinc-finger of C2H2 type PyrI_C PF02748.13 MSTRG.25468.4_1 - 1.7 8.5 9.9 0.46 10.3 0.8 3.9 4 0 0 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain RabGAP-TBC PF00566.16 MSTRG.21486.4_2 - 1.5e-54 184.7 2.7 1.5e-54 184.7 2.7 2.1 2 0 0 2 2 2 1 Rab-GTPase-TBC domain LIM PF00412.20 MSTRG.12390.1_2 - 3.7e-31 107.0 31.6 4.8e-12 45.8 6.2 3.9 4 0 0 4 4 4 3 LIM domain tRNA-synt_2d PF01409.18 MSTRG.21762.1_1 - 1.8e-90 302.5 0.0 2.6e-90 302.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2 PF00152.18 MSTRG.21762.1_1 - 0.0014 17.6 0.4 0.0049 15.9 0.1 1.9 2 1 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.23 MSTRG.21762.1_1 - 0.028 14.3 0.0 0.046 13.5 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) Ribosomal_L4 PF00573.20 MSTRG.28866.1_1 - 0.91 9.0 2.9 1.2 8.6 2.9 1.2 1 0 0 1 1 1 0 Ribosomal protein L4/L1 family Zona_pellucida PF00100.21 MSTRG.28866.1_2 - 2e-11 44.0 0.3 2.3e-11 43.9 0.3 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain Pkinase PF00069.23 MSTRG.21979.1_1 - 4.6e-35 121.1 0.0 6.6e-35 120.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.21979.1_1 - 4.2e-34 117.9 0.1 5.7e-34 117.4 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TGF_beta_GS PF08515.10 MSTRG.21979.1_1 - 1.1e-16 59.9 0.4 3e-16 58.5 0.4 1.8 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif APH PF01636.21 MSTRG.21979.1_1 - 0.11 12.3 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family MHC_I PF00129.16 MSTRG.16139.3_3 - 4.4e-31 107.7 3.3 5.9e-31 107.3 3.3 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 MSTRG.16139.3_3 - 1.7e-09 37.9 0.0 5.4e-09 36.3 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.3 MSTRG.16139.3_3 - 0.0038 16.6 0.0 0.0064 15.9 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain Ig_3 PF13927.4 MSTRG.16139.3_3 - 0.0056 17.1 0.2 0.042 14.3 0.0 2.6 3 0 0 3 3 3 1 Immunoglobulin domain Marek_A PF02124.13 MSTRG.16139.3_3 - 0.01 15.6 0.1 0.015 15.0 0.1 1.2 1 0 0 1 1 1 1 Marek's disease glycoprotein A EphA2_TM PF14575.4 MSTRG.16139.3_3 - 0.023 15.3 0.1 0.058 14.1 0.1 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.4 MSTRG.16139.3_3 - 0.027 14.2 0.6 0.057 13.2 0.6 1.4 1 0 0 1 1 1 0 TMEM154 protein family DUF1191 PF06697.10 MSTRG.16139.3_3 - 0.034 13.2 0.3 0.054 12.6 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) ig PF00047.23 MSTRG.16139.3_3 - 0.037 14.1 0.0 0.18 11.9 0.0 2.2 2 0 0 2 2 2 0 Immunoglobulin domain DUF4448 PF14610.4 MSTRG.16139.3_3 - 0.053 13.2 0.0 0.099 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF4083 PF13314.4 MSTRG.16139.3_3 - 0.067 13.0 1.3 0.12 12.2 1.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) DUF912 PF06024.10 MSTRG.16139.3_3 - 0.096 12.9 0.3 0.22 11.7 0.3 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF3827 PF12877.5 MSTRG.16139.3_3 - 0.21 9.8 0.9 0.31 9.2 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) UPF0258 PF06789.10 MSTRG.16139.3_3 - 0.53 10.3 5.9 0.94 9.5 5.9 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0258) DUF1180 PF06679.10 MSTRG.16139.3_3 - 2.6 8.3 6.6 0.26 11.6 1.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) DTW PF03942.13 MSTRG.9254.1_1 - 6.2e-45 153.2 1.1 7.7e-45 152.9 1.1 1.1 1 0 0 1 1 1 1 DTW domain DUF367 PF04034.11 MSTRG.9254.1_1 - 0.035 13.7 0.1 0.091 12.4 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF367) DIX PF00778.15 MSTRG.5281.2_3 - 7.3e-31 105.7 0.4 1.4e-30 104.8 0.4 1.5 1 0 0 1 1 1 1 DIX domain RGS PF00615.17 MSTRG.5281.2_3 - 3.4e-27 94.9 0.5 6e-27 94.1 0.5 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain AXIN1_TNKS_BD PF16646.3 MSTRG.5281.2_3 - 2.1e-23 82.8 3.2 6.2e-23 81.3 3.2 1.9 1 0 0 1 1 1 1 Axin-1 tankyrase binding domain Axin_b-cat_bind PF08833.8 MSTRG.5281.2_3 - 4.8e-11 42.5 0.1 1.9e-10 40.5 0.1 2.1 1 0 0 1 1 1 1 Axin beta-catenin binding domain LRR_8 PF13855.4 MSTRG.27516.1_2 - 1.7e-72 238.9 71.9 6.4e-13 48.1 0.9 12.2 7 3 5 12 12 12 11 Leucine rich repeat LRR_4 PF12799.5 MSTRG.27516.1_2 - 6.6e-29 99.3 63.7 0.0024 18.1 0.8 13.5 8 4 9 17 17 17 14 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 MSTRG.27516.1_2 - 6.7e-23 80.9 0.0 7.2e-05 22.6 0.0 6.2 2 1 2 6 6 6 6 Leucine rich repeats (6 copies) TIR PF01582.18 MSTRG.27516.1_2 - 3e-10 40.1 0.0 4.8e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 TIR domain LRR_9 PF14580.4 MSTRG.27516.1_2 - 4.1e-10 39.3 19.1 0.00068 19.0 0.0 6.3 2 2 4 8 8 8 4 Leucine-rich repeat TIR_2 PF13676.4 MSTRG.27516.1_2 - 1.8e-06 28.1 0.1 3.2e-06 27.3 0.1 1.4 1 0 0 1 1 1 1 TIR domain LRR_1 PF00560.31 MSTRG.27516.1_2 - 0.075 13.4 49.0 7.1 7.4 0.0 13.9 14 3 0 14 14 14 0 Leucine Rich Repeat LRRNT PF01462.16 MSTRG.27516.1_2 - 0.3 10.6 3.3 0.19 11.3 0.2 2.4 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain LRR_3 PF07725.10 MSTRG.27516.1_2 - 5.6 6.9 11.0 0.21 11.3 0.5 4.0 4 0 0 4 4 4 0 Leucine Rich Repeat EGF_CA PF07645.13 MSTRG.17718.1_3 - 3.1e-143 465.7 346.7 3.5e-10 39.8 5.5 25.8 25 0 0 25 25 25 22 Calcium-binding EGF domain cEGF PF12662.5 MSTRG.17718.1_3 - 5.5e-93 304.2 188.5 9.2e-08 31.7 2.2 25.2 24 0 0 24 24 24 22 Complement Clr-like EGF-like TB PF00683.15 MSTRG.17718.1_3 - 1.6e-34 117.1 83.0 2e-14 52.8 4.1 8.3 7 0 0 7 7 7 4 TB domain EGF PF00008.25 MSTRG.17718.1_3 - 1.5e-16 60.2 370.0 0.00026 21.1 7.7 27.0 27 0 0 27 27 27 16 EGF-like domain FXa_inhibition PF14670.4 MSTRG.17718.1_3 - 1.2e-12 47.7 348.9 0.0011 19.0 4.8 26.2 22 3 4 26 26 26 16 Coagulation Factor Xa inhibitory site EGF_3 PF12947.5 MSTRG.17718.1_3 - 0.00015 21.7 1.6 0.00015 21.7 1.6 26.2 25 1 1 26 26 26 13 EGF domain hEGF PF12661.5 MSTRG.17718.1_3 - 0.0028 18.1 23.5 0.004 17.6 8.1 29.2 28 0 0 28 28 28 11 Human growth factor-like EGF EGF_2 PF07974.11 MSTRG.17718.1_3 - 0.0037 17.5 13.2 0.0037 17.5 13.2 24.5 24 1 1 25 25 25 9 EGF-like domain Plasmod_Pvs28 PF06247.9 MSTRG.17718.1_3 - 0.0058 16.8 3.3 0.0058 16.8 3.3 20.8 23 1 1 24 24 24 10 Pvs28 EGF domain DEAD PF00270.27 MSTRG.20539.1_2 - 4e-30 104.7 0.1 1.2e-29 103.2 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.20539.1_2 - 4.7e-26 91.2 0.0 1.1e-25 90.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_30 PF13604.4 MSTRG.20539.1_2 - 0.05 13.2 0.0 0.086 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain MANEC PF07502.12 MSTRG.19979.2_1 - 4.3e-27 94.1 3.2 4.3e-27 94.1 3.2 2.4 2 0 0 2 2 2 1 MANEC domain PAN_3 PF08277.10 MSTRG.19979.2_1 - 0.059 13.0 4.4 0.22 11.2 4.4 1.9 1 0 0 1 1 1 0 PAN-like domain Kunitz_BPTI PF00014.21 MSTRG.19979.2_3 - 4e-17 62.1 4.6 4e-17 62.1 4.6 2.2 2 0 0 2 2 2 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Ldl_recept_a PF00057.16 MSTRG.19979.2_3 - 1e-06 28.7 15.9 2.9e-06 27.2 15.9 1.8 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Y_Y_Y PF07495.11 MSTRG.19979.2_3 - 0.016 15.0 0.0 0.028 14.2 0.0 1.4 1 0 0 1 1 1 0 Y_Y_Y domain Glyco_transf_20 PF00982.19 MSTRG.7773.1_1 - 0.083 11.4 0.0 0.1 11.1 0.0 1.0 1 0 0 1 1 1 0 Glycosyltransferase family 20 HHV-1_VABD PF16852.3 MSTRG.7773.1_2 - 0.0099 15.7 1.7 0.017 15.0 1.7 1.3 1 0 0 1 1 1 1 Herpes viral adaptor-to-host cellular mRNA binding domain GED PF02212.16 MSTRG.12695.1_1 - 0.088 12.8 1.7 0.23 11.5 1.7 1.7 1 0 0 1 1 1 0 Dynamin GTPase effector domain SHNi-TPR PF10516.7 MSTRG.12695.1_3 - 6.4e-16 57.4 1.8 4.8e-14 51.4 0.7 2.5 2 0 0 2 2 2 1 SHNi-TPR TPR_12 PF13424.4 MSTRG.12695.1_3 - 4.1e-10 39.7 4.6 1.5e-09 37.8 1.0 2.6 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.12695.1_3 - 5.3e-09 35.4 0.1 0.00072 19.4 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.12695.1_3 - 6.3e-09 35.2 0.0 0.001 18.7 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.12695.1_3 - 9.3e-07 28.5 0.1 0.013 15.5 0.0 3.7 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.12695.1_3 - 0.00039 20.9 0.1 0.66 10.8 0.0 3.5 2 1 1 3 3 2 1 Tetratricopeptide repeat Paf67 PF10255.7 MSTRG.12695.1_3 - 0.0041 16.0 0.0 0.0074 15.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_16 PF13432.4 MSTRG.12695.1_3 - 0.007 16.9 0.9 0.3 11.7 0.0 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.12695.1_3 - 0.018 15.6 0.1 4 8.2 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.12695.1_3 - 0.038 13.6 0.4 15 5.2 0.0 3.7 4 1 1 5 5 5 0 TPR repeat TPR_7 PF13176.4 MSTRG.12695.1_3 - 0.048 13.6 0.3 1.8 8.7 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.12695.1_3 - 0.37 10.9 4.6 1.6 8.8 2.2 3.1 2 2 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.4 MSTRG.12695.1_3 - 0.59 10.6 4.3 1.9 9.0 0.5 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.12695.1_3 - 2.1 8.2 7.1 0.39 10.5 0.1 3.4 5 0 0 5 5 5 0 Tetratricopeptide repeat Ribosomal_S17 PF00366.18 MSTRG.14254.1_1 - 7e-29 99.6 0.6 9.4e-29 99.2 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein S17 Ribosomal_S17_N PF16205.3 MSTRG.14254.1_1 - 2e-21 76.0 0.2 4.8e-21 74.8 0.1 1.7 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal PRF PF06875.9 MSTRG.14254.1_1 - 0.021 14.1 0.1 0.032 13.5 0.1 1.2 1 0 0 1 1 1 0 Plethodontid receptivity factor PRF LETM1 PF07766.11 MSTRG.1241.1_1 - 9.9e-89 297.1 6.0 9.9e-89 297.1 6.0 2.9 4 0 0 4 4 4 1 LETM1-like protein EF-hand_6 PF13405.4 MSTRG.1241.1_1 - 0.0021 17.7 0.3 0.056 13.3 0.3 3.1 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.30 MSTRG.1241.1_1 - 0.0084 15.5 1.1 0.06 12.8 0.4 2.6 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.4 MSTRG.1241.1_1 - 0.018 14.7 1.2 0.043 13.4 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_7 PF13499.4 MSTRG.1241.1_1 - 0.71 10.3 5.8 0.13 12.6 0.4 2.6 2 1 0 2 2 2 0 EF-hand domain pair Pkinase PF00069.23 MSTRG.1103.1_1 - 2.6e-71 240.0 0.0 3.2e-71 239.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.1103.1_1 - 2.8e-41 141.4 0.0 3.7e-41 141.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.1103.1_1 - 8.9e-09 34.9 0.0 4.9e-08 32.5 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.12 MSTRG.1103.1_1 - 0.046 12.9 0.0 0.078 12.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 MSTRG.1103.1_1 - 0.085 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family COX6C PF02937.13 MSTRG.13653.2_1 - 1.1e-32 111.8 0.2 1.9e-32 111.1 0.2 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIc SF3a60_bindingd PF12108.6 MSTRG.13653.2_1 - 5.8 6.8 6.2 0.36 10.6 0.7 1.7 2 0 0 2 2 2 0 Splicing factor SF3a60 binding domain PKK PF12474.6 MSTRG.20575.3_3 - 2.5e-40 137.7 53.2 9.2e-38 129.3 40.3 3.6 4 0 0 4 4 4 3 Polo kinase kinase 5_nucleotid PF05761.12 MSTRG.14450.1_2 - 5.6e-128 427.6 2.0 6.7e-128 427.3 2.0 1.1 1 0 0 1 1 1 1 5' nucleotidase family HAD_2 PF13419.4 MSTRG.14450.1_2 - 0.003 17.5 0.0 0.016 15.1 0.0 2.2 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Laminin_G_3 PF13385.4 MSTRG.15297.1_3 - 0.00098 19.2 0.0 0.0014 18.6 0.0 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.22 MSTRG.15297.1_3 - 0.064 13.7 0.0 0.12 12.8 0.0 1.4 1 1 0 1 1 1 0 Laminin G domain PHZA_PHZB PF03284.11 MSTRG.15297.1_3 - 0.15 11.6 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Phenazine biosynthesis protein A/B DUF859 PF05895.10 MSTRG.15297.1_3 - 0.17 10.2 0.0 0.23 9.8 0.0 1.1 1 0 0 1 1 1 0 Siphovirus protein of unknown function (DUF859) Gal_Lectin PF02140.16 MSTRG.3166.3_1 - 1.6e-35 121.2 13.8 3e-20 72.3 2.9 2.4 2 0 0 2 2 2 2 Galactose binding lectin domain DUF4191 PF13829.4 MSTRG.3166.3_1 - 0.088 12.0 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) Sin3_corepress PF08295.10 MSTRG.3166.3_1 - 0.14 12.1 0.2 0.28 11.1 0.2 1.5 1 0 0 1 1 1 0 Sin3 family co-repressor Homeobox PF00046.27 MSTRG.19063.1_1 - 1.4e-05 24.7 1.2 2.9e-05 23.6 0.3 2.1 3 0 0 3 3 3 1 Homeobox domain DUF1180 PF06679.10 MSTRG.24354.2_1 - 3.4e-13 50.2 0.0 1.3e-12 48.3 0.0 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) UTP15_C PF09384.8 MSTRG.1859.2_1 - 7.4e-45 152.2 0.2 1.1e-44 151.7 0.2 1.2 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.30 MSTRG.1859.2_1 - 1.5e-23 82.5 3.3 2.4e-05 24.9 0.0 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.1859.2_1 - 1.9e-10 40.7 0.1 0.0098 16.0 0.0 4.3 2 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.4 MSTRG.1859.2_1 - 0.0001 22.2 0.2 0.85 9.5 0.0 3.4 3 1 1 4 4 4 2 Ciliary BBSome complex subunit 2, middle region Utp12 PF04003.10 MSTRG.1859.2_1 - 0.055 13.6 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Dip2/Utp12 Family Acetyltransf_1 PF00583.23 MSTRG.9427.1_1 - 7.8e-14 51.8 0.0 1.1e-13 51.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.5 MSTRG.9427.1_1 - 6.6e-07 29.5 0.0 1.2e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.5 MSTRG.9427.1_1 - 4.7e-05 23.2 0.0 8.5e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.8 MSTRG.9427.1_1 - 0.00031 20.5 0.0 0.00064 19.5 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.5 MSTRG.9427.1_1 - 0.062 13.8 0.0 0.092 13.3 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Cu-oxidase_4 PF02578.13 MSTRG.229.2_3 - 3.7e-60 203.1 0.0 4.5e-60 202.9 0.0 1.1 1 0 0 1 1 1 1 Multi-copper polyphenol oxidoreductase laccase ThiF PF00899.19 MSTRG.7140.1_1 - 1.6e-49 168.4 0.0 2.6e-49 167.7 0.0 1.3 1 0 0 1 1 1 1 ThiF family UDPG_MGDP_dh_N PF03721.12 MSTRG.7140.1_1 - 0.0023 17.4 0.0 0.0038 16.7 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pox_A_type_inc PF04508.10 MSTRG.7140.1_1 - 0.025 14.3 2.4 0.054 13.2 2.4 1.6 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Sacchrp_dh_NADP PF03435.16 MSTRG.7140.1_1 - 0.057 13.5 0.8 1.1 9.4 0.8 2.6 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain CBM_21 PF03370.11 MSTRG.18229.1_2 - 3.2e-25 88.3 0.0 4.5e-25 87.9 0.0 1.2 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.3 MSTRG.18229.1_2 - 3.9e-10 40.0 0.0 6.4e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) RRM_1 PF00076.20 MSTRG.20241.1_3 - 5.5e-27 93.3 1.1 3.1e-12 46.0 0.0 4.0 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 MSTRG.20241.1_3 - 1.7e-07 30.8 0.4 0.0037 16.7 0.1 2.4 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 MSTRG.20241.1_3 - 0.021 14.7 1.0 1.3 8.9 0.0 3.5 3 0 0 3 3 3 0 RNA binding motif Nup35_RRM_2 PF14605.4 MSTRG.20241.1_3 - 0.18 11.6 0.2 3.1 7.7 0.0 2.4 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif TRP_2 PF08344.9 MSTRG.3345.1_3 - 1.9e-28 98.4 0.3 3.9e-28 97.3 0.3 1.6 1 0 0 1 1 1 1 Transient receptor ion channel II Ank PF00023.28 MSTRG.3345.1_3 - 0.0089 16.3 0.0 0.03 14.6 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.4 MSTRG.3345.1_3 - 0.011 16.1 0.0 0.071 13.6 0.0 2.4 2 0 0 2 2 2 0 Ankyrin repeat Ank_2 PF12796.5 MSTRG.3345.1_3 - 0.037 14.5 0.0 0.09 13.2 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) zf-C4 PF00105.16 MSTRG.2863.1_1 - 1.6e-33 114.8 12.3 2.7e-33 114.1 12.3 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) UQ_con PF00179.24 MSTRG.22040.1_2 - 3.5e-46 156.2 0.0 5e-46 155.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.4 MSTRG.22040.1_2 - 0.014 15.0 0.0 0.033 13.8 0.0 1.6 2 0 0 2 2 2 0 Prokaryotic E2 family B UEV PF05743.11 MSTRG.22040.1_2 - 0.042 13.6 0.0 0.07 12.9 0.0 1.3 1 0 0 1 1 1 0 UEV domain C1q PF00386.19 MSTRG.3610.2_3 - 8e-48 161.7 0.7 2.8e-24 85.6 0.1 2.4 2 0 0 2 2 2 2 C1q domain TNF PF00229.16 MSTRG.3610.2_3 - 0.0005 19.9 2.0 0.53 10.1 0.2 3.6 2 2 0 2 2 2 2 TNF(Tumour Necrosis Factor) family PPC PF04151.13 MSTRG.3610.2_3 - 0.0038 18.2 5.3 0.49 11.4 0.2 3.1 2 1 1 3 3 3 2 Bacterial pre-peptidase C-terminal domain Golgin_A5 PF09787.7 MSTRG.3610.2_3 - 0.026 13.8 1.3 0.15 11.4 0.0 2.2 2 0 0 2 2 2 0 Golgin subfamily A member 5 DUF4658 PF15555.4 MSTRG.3610.2_3 - 0.031 14.2 0.1 0.075 12.9 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4658) YABBY PF04690.11 MSTRG.3610.2_3 - 0.051 14.0 0.2 0.14 12.6 0.0 1.7 2 0 0 2 2 2 0 YABBY protein DUF4200 PF13863.4 MSTRG.3610.2_3 - 0.057 13.7 1.0 0.9 9.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) IncA PF04156.12 MSTRG.3610.2_3 - 0.13 11.9 1.3 0.68 9.6 0.0 2.0 2 0 0 2 2 2 0 IncA protein THOC7 PF05615.11 MSTRG.3610.2_3 - 3.6 7.7 7.1 10 6.3 1.7 2.2 2 0 0 2 2 2 0 Tho complex subunit 7 SUFU_C PF12470.6 MSTRG.4148.2_2 - 7.1e-85 284.1 0.0 9.9e-85 283.6 0.0 1.2 1 0 0 1 1 1 1 Suppressor of Fused Gli/Ci N terminal binding domain SUFU PF05076.11 MSTRG.4148.2_2 - 2.1e-52 177.5 0.0 3.3e-52 176.8 0.0 1.3 1 0 0 1 1 1 1 Suppressor of fused protein (SUFU) Hydrolase_4 PF12146.6 MSTRG.14713.2_1 - 2.3e-13 49.8 0.0 1.9e-08 33.7 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.18 MSTRG.14713.2_1 - 4.7e-10 39.4 0.0 2.3e-08 33.8 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 MSTRG.14713.2_1 - 6.9e-08 33.2 0.1 1.1e-07 32.6 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.16 MSTRG.14713.2_1 - 0.0014 18.1 0.2 0.011 15.2 0.1 1.9 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.19 MSTRG.14713.2_1 - 0.0084 15.5 0.1 0.051 12.9 0.1 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.11 MSTRG.14713.2_1 - 0.071 12.8 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Myb_DNA-binding PF00249.29 MSTRG.24276.1_1 - 1.1e-24 86.1 0.3 5.6e-15 55.1 0.1 3.9 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 MSTRG.24276.1_1 - 4.4e-13 49.1 1.8 4.3e-07 29.9 0.0 4.0 2 1 2 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.4 MSTRG.24276.1_1 - 0.58 10.5 3.9 0.44 10.8 0.3 2.6 3 0 0 3 3 3 0 Myb/SANT-like DNA-binding domain fn3 PF00041.19 MSTRG.11855.1_1 - 0.00011 22.3 0.2 0.00033 20.8 0.1 1.9 2 0 0 2 2 2 1 Fibronectin type III domain IL4Ra_N PF09238.8 MSTRG.11855.1_1 - 0.093 12.9 0.2 0.44 10.8 0.3 2.0 2 1 0 2 2 2 0 Interleukin-4 receptor alpha chain, N-terminal RCDG1 PF15725.3 MSTRG.21974.1_2 - 0.22 11.8 3.6 0.49 10.7 3.6 1.6 1 0 0 1 1 1 0 Renal cancer differentiation gene 1 protein Ribosomal_L29e PF01779.15 MSTRG.14176.1_2 - 1.1e-26 92.7 8.0 1.1e-26 92.7 8.0 2.0 2 0 0 2 2 2 1 Ribosomal L29e protein family RNA_pol_A_bac PF01000.24 MSTRG.8656.1_3 - 1.5e-29 102.5 0.0 3e-29 101.5 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.22 MSTRG.8656.1_3 - 6.5e-24 83.0 0.0 9e-24 82.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain FAM195 PF14799.4 MSTRG.18895.1_3 - 4e-29 100.8 0.1 6.3e-29 100.2 0.1 1.3 1 0 0 1 1 1 1 FAM195 family RAMP4 PF06624.10 MSTRG.29812.1_2 - 4.3e-26 90.6 0.2 7.6e-26 89.8 0.2 1.4 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 DUF1206 PF06724.9 MSTRG.29812.1_2 - 0.02 14.9 0.1 0.03 14.2 0.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1206) SAM_1 PF00536.28 MSTRG.24265.4_1 - 9e-18 64.4 0.1 1.5e-17 63.7 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 MSTRG.24265.4_1 - 3.9e-11 42.7 0.1 6.8e-11 42.0 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Glycos_transf_3 PF00591.19 MSTRG.24265.4_3 - 4.5e-40 137.7 2.2 6e-40 137.3 2.2 1.2 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.15 MSTRG.24265.4_3 - 9e-18 63.7 0.0 1.6e-17 63.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain PYNP_C PF07831.11 MSTRG.24265.4_3 - 1.3e-09 37.4 0.0 2.7e-09 36.4 0.0 1.6 1 0 0 1 1 1 1 Pyrimidine nucleoside phosphorylase C-terminal domain Plectin PF00681.18 MSTRG.11513.1_2 - 6.5e-42 141.0 0.5 7.4e-13 48.0 0.1 7.0 5 1 2 7 7 7 5 Plectin repeat Spectrin PF00435.19 MSTRG.11513.1_2 - 7.1e-06 26.3 4.7 7.3e-05 23.1 2.2 12.4 8 5 2 12 12 12 4 Spectrin repeat FAF PF11250.6 MSTRG.11513.1_2 - 0.14 12.3 0.0 0.55 10.4 0.0 2.1 1 0 0 1 1 1 0 Fantastic Four meristem regulator Baculo_PEP_C PF04513.10 MSTRG.11513.1_2 - 3.2 7.7 27.0 0.51 10.2 0.3 7.4 4 1 2 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus HALZ PF02183.16 MSTRG.11513.1_2 - 3.4 7.8 23.6 0.16 12.1 0.5 7.6 7 0 0 7 7 7 0 Homeobox associated leucine zipper Zona_pellucida PF00100.21 MSTRG.7735.1_3 - 9.5e-46 156.5 0.1 1.3e-45 156.0 0.1 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain FXa_inhibition PF14670.4 MSTRG.7735.1_3 - 6.3e-13 48.6 53.7 3.6e-08 33.4 11.7 4.6 4 0 0 4 4 4 3 Coagulation Factor Xa inhibitory site cEGF PF12662.5 MSTRG.7735.1_3 - 2.5e-05 24.0 16.3 0.0012 18.6 1.3 3.9 3 0 0 3 3 3 2 Complement Clr-like EGF-like EGF_CA PF07645.13 MSTRG.7735.1_3 - 0.00098 19.2 10.9 0.00098 19.2 10.9 4.7 3 1 1 4 4 4 1 Calcium-binding EGF domain TAL_effector PF03377.11 MSTRG.25983.1_2 - 0.13 12.1 0.1 0.25 11.2 0.1 1.5 1 0 0 1 1 1 0 TAL effector repeat ST7 PF04184.10 MSTRG.22573.2_3 - 5.4e-302 1001.9 0.4 6.2e-302 1001.7 0.4 1.0 1 0 0 1 1 1 1 ST7 protein TPR_6 PF13174.4 MSTRG.22573.2_3 - 0.0016 18.8 0.0 0.0073 16.7 0.0 2.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.22573.2_3 - 0.089 12.8 0.1 14 5.9 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Clathrin PF00637.18 MSTRG.22573.2_3 - 0.091 12.5 0.1 0.18 11.5 0.1 1.4 1 0 0 1 1 1 0 Region in Clathrin and VPS TPR_19 PF14559.4 MSTRG.22573.2_3 - 0.6 10.5 3.1 1.7 9.1 0.0 2.9 3 1 0 3 3 3 0 Tetratricopeptide repeat CCDC106 PF15794.3 MSTRG.19758.2_3 - 6.1e-80 268.0 1.5 1.9e-60 204.2 0.8 2.1 2 0 0 2 2 2 2 Coiled-coil domain-containing protein 106 Chibby PF14645.4 MSTRG.19758.2_3 - 0.1 12.9 0.0 0.33 11.2 0.0 1.8 2 0 0 2 2 2 0 Chibby family DUF4713 PF15831.3 MSTRG.6417.1_3 - 4e-10 39.9 9.9 6.2e-10 39.2 9.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4713) TMEM52 PF14979.4 MSTRG.6417.1_3 - 0.0067 16.2 4.8 0.011 15.6 4.8 1.3 1 0 0 1 1 1 1 Transmembrane 52 Tweety PF04906.11 MSTRG.6417.1_3 - 0.079 11.5 2.6 0.11 11.0 2.6 1.1 1 0 0 1 1 1 0 Tweety RhoGEF PF00621.18 MSTRG.21560.5_1 - 2e-32 112.8 0.1 2.6e-32 112.4 0.1 1.1 1 0 0 1 1 1 1 RhoGEF domain PH_10 PF15411.4 MSTRG.21560.5_1 - 0.00027 21.0 0.1 0.00066 19.8 0.1 1.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 MSTRG.21560.5_1 - 0.014 15.8 0.0 0.03 14.7 0.0 1.5 1 0 0 1 1 1 0 PH domain IQ_SEC7_PH PF16453.3 MSTRG.21560.5_1 - 0.15 11.9 0.0 0.29 11.0 0.0 1.4 1 0 0 1 1 1 0 PH domain PH_5 PF15405.4 MSTRG.21560.5_1 - 0.21 11.6 0.3 0.98 9.4 0.1 2.0 1 1 1 2 2 2 0 Pleckstrin homology domain DLEU7 PF15760.3 MSTRG.21560.5_3 - 0.25 10.7 7.3 0.52 9.6 7.3 1.5 1 0 0 1 1 1 0 Leukemia-associated protein 7 INT_SG_DDX_CT_C PF15300.4 MSTRG.1159.3_1 - 2.1e-25 88.1 3.1 3.5e-25 87.4 3.1 1.4 1 0 0 1 1 1 1 INTS6/SAGE1/DDX26B/CT45 C-terminus DBD_Tnp_Hermes PF10683.7 MSTRG.18745.1_3 - 3.3e-06 26.6 0.0 7.5e-06 25.4 0.0 1.6 1 0 0 1 1 1 1 Hermes transposase DNA-binding domain Hyccin PF09790.7 MSTRG.5084.1_3 - 2.1e-112 375.2 0.1 2.7e-112 374.9 0.1 1.1 1 0 0 1 1 1 1 Hyccin DMA PF03474.12 MSTRG.6074.1_2 - 0.0074 15.7 0.0 0.014 14.9 0.0 1.4 1 0 0 1 1 1 1 DMRTA motif Pkinase PF00069.23 MSTRG.13815.3_3 - 5.6e-29 101.2 0.0 1.2e-28 100.1 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.13815.3_3 - 1.8e-09 37.2 0.0 2.8e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Nup96 PF12110.6 MSTRG.13815.3_3 - 0.027 13.5 0.1 0.068 12.1 0.1 1.6 1 0 0 1 1 1 0 Nuclear protein 96 Kdo PF06293.12 MSTRG.13815.3_3 - 0.15 11.3 0.0 0.24 10.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FIIND PF13553.4 MSTRG.13305.1_2 - 3.6e-40 137.8 0.0 5.9e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 Function to find CARD PF00619.19 MSTRG.13305.1_2 - 1.1e-10 41.2 0.0 2.3e-10 40.2 0.0 1.5 1 0 0 1 1 1 1 Caspase recruitment domain SH3-WW_linker PF16618.3 MSTRG.21327.6_2 - 9.1e-46 156.7 27.0 9.1e-46 156.7 27.0 3.0 3 1 0 3 3 3 1 Linker region between SH3 and WW domains on ARHGAP12 SH3_9 PF14604.4 MSTRG.21327.6_2 - 2.6e-11 43.0 0.1 5.4e-11 42.0 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.24 MSTRG.21327.6_2 - 9.3e-10 38.2 6.8 1.4e-05 24.8 1.1 2.8 2 0 0 2 2 2 2 WW domain PH PF00169.27 MSTRG.21327.6_2 - 4.1e-09 36.8 0.6 1.4e-08 35.0 0.1 2.3 2 0 0 2 2 2 1 PH domain SH3_1 PF00018.26 MSTRG.21327.6_2 - 9.8e-06 24.9 0.2 2.5e-05 23.6 0.2 1.8 1 0 0 1 1 1 1 SH3 domain PH_9 PF15410.4 MSTRG.21327.6_2 - 0.0019 18.5 0.1 0.0072 16.6 0.1 1.9 1 1 0 1 1 1 1 Pleckstrin homology domain PPDFL PF15060.4 MSTRG.21327.6_2 - 0.011 16.2 0.0 0.034 14.6 0.0 1.8 1 0 0 1 1 1 0 Differentiation and proliferation regulator Reprolysin PF01421.17 MSTRG.20762.1_2 - 8.2e-22 78.0 2.1 9.9e-22 77.7 2.1 1.1 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_3 PF13582.4 MSTRG.20762.1_2 - 0.0094 16.3 0.2 0.014 15.7 0.2 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like DUF3338 PF11819.6 MSTRG.13062.2_2 - 3.3e-51 172.7 4.4 1.1e-50 171.0 4.4 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3338) FERM_C PF09380.8 MSTRG.13062.2_2 - 1.2e-22 80.0 0.2 2.3e-22 79.0 0.2 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain DEAD PF00270.27 MSTRG.6264.1_1 - 1.4e-50 171.4 0.0 4.1e-50 169.9 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.6264.1_1 - 1.3e-31 109.1 1.2 3.8e-31 107.6 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.3 MSTRG.6264.1_1 - 0.04 13.0 0.0 0.06 12.4 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.13 MSTRG.6264.1_1 - 0.056 13.3 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit CMS1 PF14617.4 MSTRG.6264.1_1 - 0.13 11.5 0.0 0.3 10.3 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DUF4746 PF15928.3 MSTRG.6264.1_2 - 2.9 7.1 9.8 4.2 6.6 9.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Leu_zip PF15294.4 MSTRG.16621.2_1 - 4e-05 23.1 18.4 4e-05 23.1 18.4 8.7 2 1 8 10 10 10 2 Leucine zipper ATG16 PF08614.9 MSTRG.16621.2_1 - 0.00021 21.4 20.8 0.00021 21.4 20.8 11.9 2 1 11 13 13 13 5 Autophagy protein 16 (ATG16) Reo_sigmaC PF04582.10 MSTRG.16621.2_1 - 0.4 9.9 90.6 0.11 11.7 7.2 9.0 2 1 8 10 10 10 0 Reovirus sigma C capsid protein GIY-YIG PF01541.22 MSTRG.25902.2_2 - 6e-16 58.4 0.0 9.9e-16 57.7 0.0 1.3 1 0 0 1 1 1 1 GIY-YIG catalytic domain T5orf172 PF10544.7 MSTRG.25902.2_2 - 0.075 13.4 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 T5orf172 domain fn3 PF00041.19 MSTRG.4605.1_2 - 2.9e-15 56.2 2.2 0.0067 16.6 0.0 4.6 4 0 0 4 4 4 3 Fibronectin type III domain Lep_receptor_Ig PF06328.9 MSTRG.4605.1_2 - 2.9e-08 33.5 0.0 6.6e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 Ig-like C2-type domain fn3_2 PF16893.3 MSTRG.4605.1_2 - 0.0089 16.0 0.0 0.032 14.2 0.0 2.0 2 0 0 2 2 2 1 Fibronectin type III domain Ig_2 PF13895.4 MSTRG.4605.1_2 - 0.01 16.1 0.4 0.04 14.1 0.0 2.1 2 0 0 2 2 2 0 Immunoglobulin domain adh_short PF00106.23 MSTRG.17870.1_1 - 2e-06 27.3 1.4 3.9e-06 26.3 1.4 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 MSTRG.17870.1_1 - 2e-06 27.4 0.1 3.3e-06 26.7 0.1 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.19 MSTRG.17870.1_1 - 3.7e-06 26.4 0.1 4.3e-05 23.0 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family HECT PF00632.23 MSTRG.11833.2_1 - 4.9e-102 341.4 0.0 6.3e-102 341.0 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.24 MSTRG.11833.2_1 - 6.2e-16 57.9 2.5 5.2e-07 29.4 0.0 2.9 2 0 0 2 2 2 2 WW domain C2 PF00168.28 MSTRG.11833.2_1 - 1.7e-14 53.8 0.0 3.3e-14 52.9 0.0 1.5 1 0 0 1 1 1 1 C2 domain DUF5009 PF16401.3 MSTRG.27964.1_1 - 1.4e-06 27.8 0.2 1.4e-06 27.8 0.2 3.0 4 0 0 4 4 4 1 Domain of unknown function (DUF5009) DUF1624 PF07786.10 MSTRG.27964.1_1 - 2.8e-06 26.9 6.0 2.8e-06 26.9 6.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1624) Trypsin PF00089.24 MSTRG.11102.1_3 - 1.2e-56 191.9 0.2 1.4e-56 191.7 0.2 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 MSTRG.11102.1_3 - 2.9e-05 24.8 0.0 5.9e-05 23.9 0.0 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 MSTRG.11102.1_3 - 0.12 12.6 0.1 0.21 11.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Ig_3 PF13927.4 MSTRG.20178.1_2 - 7.9e-32 109.6 0.0 2e-13 50.6 0.0 3.1 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 MSTRG.20178.1_2 - 3.1e-28 97.5 0.0 4.9e-12 45.6 0.0 3.1 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.20178.1_2 - 6.8e-19 67.9 0.0 1e-08 35.3 0.0 3.0 2 1 1 3 3 3 2 Immunoglobulin domain ig PF00047.23 MSTRG.20178.1_2 - 1.7e-18 66.4 0.0 1.1e-06 28.6 0.0 3.1 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 MSTRG.20178.1_2 - 3.6e-13 49.5 0.1 0.0059 16.6 0.0 4.9 3 2 1 4 4 4 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 MSTRG.20178.1_2 - 5.7e-07 29.4 0.0 0.00029 20.7 0.0 3.2 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 MSTRG.20178.1_2 - 0.0026 18.0 0.0 4.2 7.7 0.0 3.2 3 1 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Sp38 PF07354.10 MSTRG.20178.1_2 - 0.029 13.1 0.0 0.042 12.6 0.0 1.2 1 0 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) C1-set PF07654.13 MSTRG.20178.1_2 - 0.051 13.9 0.0 0.35 11.2 0.0 2.4 3 0 0 3 3 3 0 Immunoglobulin C1-set domain Izumo-Ig PF16706.3 MSTRG.20178.1_2 - 0.13 12.2 0.0 4.8 7.2 0.0 2.7 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Scs3p PF10261.7 MSTRG.4392.2_3 - 5.1e-20 71.9 2.2 9.5e-20 71.0 2.2 1.4 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM Gal-bind_lectin PF00337.20 MSTRG.19339.1_3 - 6.6e-15 54.7 0.0 8.4e-15 54.4 0.0 1.1 1 0 0 1 1 1 1 Galactoside-binding lectin JmjC PF02373.20 MSTRG.15213.3_2 - 1.4e-08 35.1 4.5 6e-08 33.0 0.7 3.1 2 1 0 2 2 2 1 JmjC domain, hydroxylase PHD PF00628.27 MSTRG.15213.3_2 - 2.5e-08 33.6 10.3 6.1e-08 32.3 10.3 1.7 1 0 0 1 1 1 1 PHD-finger Cupin_8 PF13621.4 MSTRG.15213.3_2 - 1.6e-06 28.0 0.1 5.8e-06 26.1 0.1 1.8 1 1 0 1 1 1 1 Cupin-like domain PHD_4 PF16866.3 MSTRG.15213.3_2 - 0.22 11.5 5.8 0.61 10.1 5.8 1.7 1 0 0 1 1 1 0 PHD-finger zf-RING_2 PF13639.4 MSTRG.15213.3_2 - 4.9 7.4 10.8 15 5.8 10.8 1.9 1 0 0 1 1 1 0 Ring finger domain PL48 PF15903.3 MSTRG.19674.1_1 - 4.2e-164 545.4 0.1 5.8e-164 545.0 0.0 1.2 1 0 0 1 1 1 1 Filopodia upregulated, FAM65 HR1 PF02185.14 MSTRG.19674.1_1 - 4.3e-05 23.4 0.0 0.00016 21.6 0.0 2.0 1 0 0 1 1 1 1 Hr1 repeat HEAT_2 PF13646.4 MSTRG.19674.1_1 - 0.00061 20.0 3.3 0.74 10.1 0.4 2.7 1 1 1 2 2 2 2 HEAT repeats HTH_Tnp_Tc3_2 PF01498.16 MSTRG.14681.1_1 - 4.9e-18 65.0 6.3 1e-17 64.0 6.3 1.6 1 0 0 1 1 1 1 Transposase DDE_3 PF13358.4 MSTRG.14681.1_1 - 1.9e-10 40.6 1.0 3.8e-10 39.6 0.0 2.1 3 1 0 3 3 3 1 DDE superfamily endonuclease HTH_33 PF13592.4 MSTRG.14681.1_1 - 0.0021 17.5 0.7 0.0069 15.9 0.4 2.0 2 0 0 2 2 2 1 Winged helix-turn helix HTH_32 PF13565.4 MSTRG.14681.1_1 - 0.16 12.5 7.2 0.13 12.8 4.8 2.1 2 0 0 2 2 2 0 Homeodomain-like domain HTH_21 PF13276.4 MSTRG.14681.1_1 - 0.29 11.2 5.5 0.29 11.2 3.1 2.2 2 0 0 2 2 2 0 HTH-like domain Peptidase_M24 PF00557.22 MSTRG.6455.2_2 - 3.5e-55 186.8 0.0 4.7e-55 186.4 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.14 MSTRG.6455.2_2 - 7.9e-33 112.7 0.0 1.3e-32 112.0 0.0 1.3 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain ABC_membrane PF00664.21 MSTRG.11274.1_3 - 2.6e-27 96.0 18.2 3.4e-27 95.6 18.2 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.25 MSTRG.11274.1_3 - 1.3e-11 45.1 0.1 2.3e-11 44.2 0.1 1.5 1 0 0 1 1 1 1 ABC transporter DUF87 PF01935.15 MSTRG.11274.1_3 - 0.04 13.8 0.2 0.11 12.4 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_29 PF13555.4 MSTRG.11274.1_3 - 0.084 12.5 0.6 0.24 11.0 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain DUF3377 PF11857.6 MSTRG.11274.1_3 - 3.3 7.6 5.2 9.2 6.1 5.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Plasmod_MYXSPDY PF07981.9 MSTRG.23381.1_1 - 0.13 12.2 0.3 0.19 11.7 0.3 1.2 1 0 0 1 1 1 0 Plasmodium repeat_MYXSPDY PHD PF00628.27 MSTRG.15213.2_2 - 2.2e-08 33.7 10.3 8.2e-08 31.9 10.3 2.1 1 0 0 1 1 1 1 PHD-finger JmjC PF02373.20 MSTRG.15213.2_2 - 2.9e-08 34.0 4.5 8.3e-08 32.5 0.7 3.0 2 1 0 2 2 2 1 JmjC domain, hydroxylase Cupin_8 PF13621.4 MSTRG.15213.2_2 - 2.7e-06 27.3 0.1 8.1e-06 25.7 0.1 1.6 1 1 0 1 1 1 1 Cupin-like domain PHD_4 PF16866.3 MSTRG.15213.2_2 - 0.29 11.1 5.8 0.81 9.7 5.8 1.8 1 0 0 1 1 1 0 PHD-finger NUDIX PF00293.26 MSTRG.7838.1_1 - 3e-06 27.2 0.0 0.0026 17.7 0.0 2.2 2 0 0 2 2 2 2 NUDIX domain Orthoreo_P10 PF07204.9 MSTRG.29762.1_2 - 4.1e-06 26.5 0.0 6.7e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Orthoreovirus membrane fusion protein p10 TMEM52 PF14979.4 MSTRG.29762.1_2 - 0.027 14.2 0.1 0.046 13.5 0.1 1.4 1 0 0 1 1 1 0 Transmembrane 52 SBF2 PF12335.6 MSTRG.12328.1_2 - 0.00025 20.6 0.2 0.00053 19.6 0.2 1.5 1 0 0 1 1 1 1 Myotubularin protein Alg6_Alg8 PF03155.13 MSTRG.10736.1_2 - 3.2e-74 250.5 26.2 3.9e-74 250.3 26.2 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family DUF3458 PF11940.6 MSTRG.4919.3_2 - 0.025 13.5 0.2 0.035 13.0 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3458) zf-DHHC PF01529.18 MSTRG.4919.3_3 - 6.4e-35 120.0 7.3 6.4e-35 120.0 7.3 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase SH3_2 PF07653.15 MSTRG.4919.3_3 - 1.9e-07 30.5 0.0 5e-07 29.2 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Oxysterol_BP PF01237.16 MSTRG.22125.2_1 - 9.2e-90 301.0 0.1 1.7e-87 293.5 0.1 2.4 1 1 0 1 1 1 1 Oxysterol-binding protein PH PF00169.27 MSTRG.22125.2_1 - 1.9e-09 37.8 0.1 6.4e-09 36.1 0.1 1.9 1 0 0 1 1 1 1 PH domain Transcrip_reg PF01709.18 MSTRG.15562.1_2 - 1.8e-63 214.0 0.0 2.2e-63 213.7 0.0 1.1 1 0 0 1 1 1 1 Transcriptional regulator OB_NTP_bind PF07717.14 MSTRG.11526.1_3 - 1e-28 99.6 0.0 2.4e-28 98.4 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.21 MSTRG.11526.1_3 - 4.9e-24 84.5 0.1 4.9e-24 84.5 0.1 1.9 2 0 0 2 2 1 1 Helicase associated domain (HA2) Helicase_C PF00271.29 MSTRG.11526.1_3 - 1.5e-12 47.8 0.0 3e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.27 MSTRG.11526.1_3 - 2.6e-07 30.5 0.1 7.2e-07 29.0 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.4 MSTRG.11526.1_3 - 0.00016 21.9 0.1 0.00032 20.9 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.4 MSTRG.11526.1_3 - 0.00081 19.5 0.4 0.0075 16.4 0.4 2.4 1 1 0 1 1 1 1 AAA domain ResIII PF04851.13 MSTRG.11526.1_3 - 0.0047 16.8 0.0 1.2 8.9 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SRP54 PF00448.20 MSTRG.11526.1_3 - 0.0049 16.4 0.1 0.016 14.7 0.0 2.0 2 1 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_30 PF13604.4 MSTRG.11526.1_3 - 0.0057 16.3 0.1 0.0099 15.5 0.1 1.3 1 0 0 1 1 1 1 AAA domain DUF1777 PF08648.10 MSTRG.11526.1_3 - 0.0078 16.3 15.2 0.013 15.6 15.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) Flavi_DEAD PF07652.12 MSTRG.11526.1_3 - 0.0091 15.8 0.1 0.017 15.0 0.1 1.4 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_25 PF13481.4 MSTRG.11526.1_3 - 0.023 14.2 0.0 0.05 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.4 MSTRG.11526.1_3 - 0.045 13.3 0.0 0.1 12.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Atrophin-1 PF03154.13 MSTRG.11526.1_3 - 0.048 11.8 2.3 0.07 11.3 2.3 1.1 1 0 0 1 1 1 0 Atrophin-1 family IstB_IS21 PF01695.15 MSTRG.11526.1_3 - 0.067 12.8 0.1 3 7.4 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein T2SSE PF00437.18 MSTRG.11526.1_3 - 0.096 11.6 0.0 0.22 10.4 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF3915 PF13054.4 MSTRG.11526.1_3 - 0.1 12.4 5.5 0.29 11.0 5.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) HTH_IclR PF09339.8 MSTRG.11526.1_3 - 0.16 11.6 0.2 0.45 10.2 0.1 1.8 2 0 0 2 2 1 0 IclR helix-turn-helix domain Abhydrolase_1 PF00561.18 MSTRG.8326.2_3 - 6.1e-17 62.0 0.0 2.7e-10 40.2 0.1 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 MSTRG.8326.2_3 - 2.1e-12 46.7 0.0 3.5e-12 46.0 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.5 MSTRG.8326.2_3 - 1.1e-09 39.1 1.2 2.3e-09 38.1 1.2 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF915 PF06028.9 MSTRG.8326.2_3 - 0.16 11.1 0.0 0.26 10.4 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) TAFA PF12020.6 MSTRG.4483.1_1 - 9.1e-46 154.1 11.6 1.7e-45 153.2 11.6 1.5 1 0 0 1 1 1 1 TAFA family HECT PF00632.23 MSTRG.13420.1_3 - 0.077 12.3 0.0 0.84 8.9 0.0 2.1 1 1 0 1 1 1 0 HECT-domain (ubiquitin-transferase) DUF1018 PF06252.10 MSTRG.13420.1_3 - 0.17 12.8 4.8 45 5.0 0.6 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1018) Synaptobrevin PF00957.19 MSTRG.2030.1_1 - 0.00042 19.9 0.0 0.00077 19.1 0.0 1.4 1 0 0 1 1 1 1 Synaptobrevin zf-H2C2_2 PF13465.4 MSTRG.10855.1_3 - 3.5e-67 219.9 67.3 3.5e-08 33.4 0.2 10.8 11 0 0 11 11 10 9 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.10855.1_3 - 3.3e-44 146.8 63.0 1.3e-05 25.3 0.7 9.8 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.10855.1_3 - 2.2e-36 121.2 59.2 0.00022 21.7 0.7 9.9 9 0 0 9 9 9 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.10855.1_3 - 4.4e-14 51.9 49.9 0.081 12.8 0.2 9.8 9 1 0 9 9 9 8 C2H2-type zinc finger zf-Di19 PF05605.10 MSTRG.10855.1_3 - 3.3e-09 36.7 32.8 0.0031 17.6 1.1 6.2 3 1 3 7 7 7 6 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.5 MSTRG.10855.1_3 - 7.7e-06 26.0 55.7 0.35 11.2 0.5 9.7 9 0 0 9 9 9 4 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 MSTRG.10855.1_3 - 1.2e-05 24.8 51.8 0.018 14.7 1.6 8.6 9 0 0 9 9 9 5 zinc-finger C2H2-type zf-H2C2_5 PF13909.4 MSTRG.10855.1_3 - 2.6e-05 23.7 52.5 0.045 13.4 0.1 9.3 9 0 0 9 9 9 5 C2H2-type zinc-finger domain BolA PF01722.16 MSTRG.10855.1_3 - 0.035 14.3 16.0 14 5.9 0.1 5.9 2 1 3 5 5 5 0 BolA-like protein zf-C2HE PF16278.3 MSTRG.10855.1_3 - 0.064 13.6 44.3 0.75 10.2 0.8 9.3 1 1 8 9 9 9 0 C2HE / C2H2 / C2HC zinc-binding finger zinc_ribbon_15 PF17032.3 MSTRG.10855.1_3 - 0.094 13.4 34.4 0.84 10.3 0.7 5.7 3 2 2 6 6 5 0 zinc-ribbon family Zn-ribbon_8 PF09723.8 MSTRG.10855.1_3 - 0.11 12.5 30.9 0.34 10.9 0.5 6.6 1 1 8 9 9 9 0 Zinc ribbon domain ADK_lid PF05191.12 MSTRG.10855.1_3 - 0.16 11.9 13.3 6 6.8 0.6 4.7 3 2 0 3 3 3 0 Adenylate kinase, active site lid Chordopox_RPO7 PF05864.10 MSTRG.10855.1_3 - 1.3 9.2 11.9 43 4.3 0.0 6.0 7 0 0 7 7 6 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) LIM PF00412.20 MSTRG.10855.1_3 - 1.7 8.8 44.7 5.5 7.2 1.5 8.8 3 1 6 9 9 9 0 LIM domain zf-C2H2_9 PF16293.3 MSTRG.10855.1_3 - 2.2 8.1 9.4 20 5.0 0.0 5.9 7 0 0 7 7 7 0 C2H2 type zinc-finger (1 copy) Sulfotransfer_2 PF03567.12 MSTRG.27736.1_2 - 9.6e-31 107.5 0.0 1.2e-30 107.2 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase family Elf1 PF05129.11 MSTRG.27875.2_3 - 9.3e-31 105.6 1.8 1.9e-30 104.6 1.8 1.5 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like Glyco_transf_29 PF00777.16 MSTRG.8730.2_2 - 2.4e-30 105.7 0.0 3.9e-30 105.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) HNOB PF07700.13 MSTRG.3591.1_3 - 3.3e-46 157.1 0.2 4.1e-46 156.8 0.2 1.1 1 0 0 1 1 1 1 Haem-NO-binding HNOBA PF07701.12 MSTRG.3591.1_3 - 0.00049 19.5 0.2 0.00076 18.9 0.2 1.3 1 0 0 1 1 1 1 Heme NO binding associated SH3_9 PF14604.4 MSTRG.23379.1_2 - 1.1e-28 98.7 1.8 1.1e-15 57.0 0.1 2.8 3 0 0 3 3 3 2 Variant SH3 domain SH3_2 PF07653.15 MSTRG.23379.1_2 - 1.4e-26 91.8 2.0 3.1e-12 45.9 0.2 3.0 3 0 0 3 3 3 2 Variant SH3 domain SH3_1 PF00018.26 MSTRG.23379.1_2 - 2.6e-25 87.6 2.3 5.1e-13 48.3 0.2 2.5 2 0 0 2 2 2 2 SH3 domain CCDC142 PF14923.4 MSTRG.14338.1_2 - 3.1e-26 92.0 8.1 3.6e-26 91.8 8.1 1.0 1 0 0 1 1 1 1 Coiled-coil protein 142 zf-C2H2 PF00096.24 MSTRG.18187.2_3 - 8.9e-41 136.0 85.2 3.2e-06 27.1 0.8 11.0 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.18187.2_3 - 1.5e-28 97.7 69.8 6.8e-08 32.5 1.2 11.9 11 0 0 11 11 11 6 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.18187.2_3 - 5e-24 82.8 78.5 0.0015 19.0 0.4 11.3 10 1 0 10 10 10 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.18187.2_3 - 8.9e-10 38.2 65.3 0.0041 16.9 0.1 10.2 10 0 0 10 10 10 7 C2H2-type zinc finger zf-H2C2_5 PF13909.4 MSTRG.18187.2_3 - 1.3e-06 27.9 50.9 8.3e-05 22.1 2.4 8.0 9 0 0 9 9 9 5 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.6 MSTRG.18187.2_3 - 3.1e-06 27.2 54.7 0.2 11.9 0.3 10.7 10 1 0 10 10 10 4 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 MSTRG.18187.2_3 - 1.3e-05 24.7 49.2 0.11 12.1 1.2 8.4 9 0 0 9 9 9 5 zinc-finger C2H2-type zf-BED PF02892.13 MSTRG.18187.2_3 - 0.0025 17.7 0.3 0.0025 17.7 0.3 8.9 4 3 6 10 10 10 3 BED zinc finger zinc_ribbon_15 PF17032.3 MSTRG.18187.2_3 - 6.5 7.4 41.3 0.37 11.4 0.2 6.7 3 1 3 6 6 6 0 zinc-ribbon family An_peroxidase PF03098.13 MSTRG.15194.1_3 - 1.3e-174 581.5 0.0 1.6e-174 581.2 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase Fels1 PF05666.9 MSTRG.15194.1_3 - 3 7.4 6.2 0.44 10.1 0.1 2.6 3 0 0 3 3 3 0 Fels-1 Prophage Protein-like RNase_T PF00929.22 MSTRG.27473.1_3 - 3.1e-27 96.0 0.0 6.6e-27 94.9 0.0 1.5 1 1 0 1 1 1 1 Exonuclease DUF5051 PF16473.3 MSTRG.27473.1_3 - 0.0016 18.3 0.0 0.0033 17.3 0.0 1.5 1 1 0 1 1 1 1 3' exoribonuclease, RNase T-like SKA1 PF07160.10 MSTRG.19716.3_3 - 0.095 12.4 8.8 0.14 11.9 8.8 1.3 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 PAP2 PF01569.19 MSTRG.1928.1_1 - 5.9e-26 90.7 1.5 1.2e-25 89.8 1.5 1.5 1 0 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.4 MSTRG.1928.1_1 - 0.045 14.1 6.2 0.042 14.2 2.6 2.7 2 0 0 2 2 2 0 PAP2 superfamily C-terminal COX7C PF02935.14 MSTRG.1928.1_1 - 0.13 12.4 0.8 0.37 10.9 0.8 1.8 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIIc BCLP PF12304.6 MSTRG.2120.1_1 - 3.2e-73 245.1 7.4 4.5e-73 244.6 7.4 1.2 1 0 0 1 1 1 1 Beta-casein like protein DUF1168 PF06658.10 MSTRG.9698.1_2 - 0.0016 18.1 5.5 0.0021 17.8 5.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) TetR_C_8 PF14278.4 MSTRG.9698.1_2 - 0.0078 16.4 0.5 0.012 15.8 0.5 1.2 1 0 0 1 1 1 1 Transcriptional regulator C-terminal region NOA36 PF06524.10 MSTRG.9698.1_2 - 1.7 7.8 15.5 2 7.6 15.5 1.1 1 0 0 1 1 1 0 NOA36 protein Cwf_Cwc_15 PF04889.10 MSTRG.9698.1_2 - 3.6 7.1 16.9 4.4 6.8 16.9 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF3295 PF11702.6 MSTRG.9698.1_2 - 6.3 5.9 11.8 6.9 5.8 11.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) BRCT_2 PF16589.3 MSTRG.2845.1_2 - 6.4e-07 29.6 0.0 1.5e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.24 MSTRG.2845.1_2 - 0.00099 19.3 0.1 0.0019 18.5 0.1 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.5 MSTRG.2845.1_2 - 0.13 12.1 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 twin BRCT domain Ephrin PF00812.15 MSTRG.12535.1_3 - 8.5e-31 106.7 0.0 1.4e-30 106.0 0.0 1.3 1 0 0 1 1 1 1 Ephrin LNS2 PF08235.11 MSTRG.23468.4_1 - 1.2e-102 342.0 0.0 2.1e-102 341.3 0.0 1.4 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.12 MSTRG.23468.4_1 - 1.7e-43 146.6 0.0 3.2e-43 145.7 0.0 1.5 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.3 MSTRG.23468.4_1 - 5.2e-35 119.6 0.1 1.3e-34 118.3 0.1 1.7 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain WRNPLPNID PF15017.4 MSTRG.23468.4_1 - 0.0023 18.7 0.7 0.007 17.1 0.0 2.2 2 0 0 2 2 2 1 Putative WW-binding domain and destruction box Ctr PF04145.13 MSTRG.19589.1_3 - 6.5e-30 104.6 3.2 1.5e-29 103.4 3.2 1.6 1 1 0 1 1 1 1 Ctr copper transporter family GRP PF07172.9 MSTRG.19589.1_3 - 1.4 9.6 16.7 3.4 8.3 16.7 1.6 1 0 0 1 1 1 0 Glycine rich protein family Rad9 PF04139.11 MSTRG.15797.1_1 - 6.7e-48 163.2 0.0 9.7e-48 162.7 0.0 1.2 1 0 0 1 1 1 1 Rad9 Rad9 PF04139.11 MSTRG.15797.1_2 - 2.2e-35 122.2 0.0 3.2e-35 121.6 0.0 1.2 1 0 0 1 1 1 1 Rad9 RRM_1 PF00076.20 MSTRG.21160.1_1 - 4.4e-15 55.1 0.0 6.5e-15 54.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC_3 PF13917.4 MSTRG.21160.1_1 - 0.0029 17.4 0.5 0.0029 17.4 0.5 2.2 2 0 0 2 2 2 1 Zinc knuckle RRM_5 PF13893.4 MSTRG.21160.1_1 - 0.0032 16.9 0.0 0.0052 16.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.21 MSTRG.21160.1_1 - 0.0078 16.1 6.4 0.0078 16.1 6.4 1.9 2 0 0 2 2 2 1 Zinc knuckle Apt1 PF10351.7 MSTRG.21160.1_1 - 2.5 6.8 10.4 3.6 6.2 10.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain MIP-T3 PF10243.7 MSTRG.21160.1_1 - 2.5 6.6 11.4 3.3 6.2 11.4 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Kinesin PF00225.21 MSTRG.18256.3_2 - 4.2e-117 390.7 0.4 7.2e-117 389.9 0.4 1.4 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.3 MSTRG.18256.3_2 - 2.1e-78 262.5 4.7 2e-74 249.5 3.9 3.8 2 1 0 2 2 2 1 Kinesin-associated Microtub_bd PF16796.3 MSTRG.18256.3_2 - 1.8e-23 83.0 0.1 4.8e-23 81.6 0.1 1.7 1 0 0 1 1 1 1 Microtubule binding FHA PF00498.24 MSTRG.18256.3_2 - 2.4e-06 27.7 0.3 9e-06 25.8 0.1 2.2 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.3 MSTRG.18256.3_2 - 0.00095 19.3 0.0 0.0029 17.8 0.0 1.8 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain TIP120 PF08623.8 MSTRG.24240.1_1 - 2.1e-66 222.7 7.7 9.9e-65 217.2 0.7 4.4 4 1 0 4 4 4 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.4 MSTRG.24240.1_1 - 7.6e-20 71.0 4.4 0.0017 18.6 0.0 8.6 7 2 2 9 9 8 6 HEAT repeats HEAT PF02985.20 MSTRG.24240.1_1 - 2.1e-16 58.4 15.4 0.094 12.9 0.0 11.3 12 0 0 12 12 10 5 HEAT repeat HEAT_EZ PF13513.4 MSTRG.24240.1_1 - 5.1e-15 55.4 19.7 0.018 15.4 0.2 12.0 12 2 2 14 14 12 3 HEAT-like repeat CLASP_N PF12348.6 MSTRG.24240.1_1 - 4.5e-07 29.5 0.1 0.027 13.9 0.0 4.9 4 1 1 5 5 5 1 CLASP N terminal Vac14_Fab1_bd PF12755.5 MSTRG.24240.1_1 - 1.8e-06 28.3 5.3 0.071 13.6 0.1 7.0 7 2 1 8 8 8 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.5 MSTRG.24240.1_1 - 2.9e-06 27.3 16.0 0.071 13.0 0.5 7.5 6 2 2 8 8 8 2 non-SMC mitotic condensation complex subunit 1 Telomere_reg-2 PF10193.7 MSTRG.24240.1_1 - 3.6e-06 27.2 5.7 4.2 7.7 0.0 6.4 6 0 0 6 6 6 2 Telomere length regulation protein UME PF08064.11 MSTRG.24240.1_1 - 2.6e-05 23.9 15.0 0.12 12.2 0.4 7.6 7 2 1 8 8 7 2 UME (NUC010) domain Adaptin_N PF01602.18 MSTRG.24240.1_1 - 0.00025 19.6 18.2 0.25 9.7 0.3 5.6 3 3 1 5 5 5 2 Adaptin N terminal region Tti2 PF10521.7 MSTRG.24240.1_1 - 0.00047 19.6 0.2 3.9 6.8 0.0 4.2 3 1 0 3 3 3 1 Tti2 family DUF3385 PF11865.6 MSTRG.24240.1_1 - 0.00061 19.6 8.7 0.088 12.5 0.0 6.2 7 2 1 8 8 8 1 Domain of unknown function (DUF3385) MMS19_C PF12460.6 MSTRG.24240.1_1 - 0.00063 18.9 22.9 0.027 13.5 1.2 7.1 7 1 1 8 8 8 1 RNAPII transcription regulator C-terminal Dopey_N PF04118.12 MSTRG.24240.1_1 - 0.0079 15.3 5.9 0.16 11.0 0.5 4.3 3 1 3 6 6 6 1 Dopey, N-terminal DRIM PF07539.10 MSTRG.24240.1_1 - 0.0088 14.3 8.9 0.48 8.5 0.3 4.8 4 2 3 7 7 7 2 Down-regulated in metastasis RTP1_C1 PF10363.7 MSTRG.24240.1_1 - 0.0099 15.9 6.1 3.3 7.8 0.2 6.1 7 0 0 7 7 6 1 Required for nuclear transport of RNA pol II C-terminus 1 VHS PF00790.17 MSTRG.24240.1_1 - 0.012 15.3 1.7 0.18 11.5 0.1 3.3 3 0 0 3 3 3 0 VHS domain V-ATPase_H_C PF11698.6 MSTRG.24240.1_1 - 0.067 13.2 11.7 0.44 10.6 0.6 5.0 7 0 0 7 7 5 0 V-ATPase subunit H DNA_pol_B_thumb PF14791.4 MSTRG.24679.1_3 - 1.5e-20 72.9 0.1 3.6e-20 71.7 0.1 1.7 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.7 MSTRG.24679.1_3 - 9.7e-15 54.1 0.1 1.7e-14 53.2 0.1 1.4 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.4 MSTRG.24679.1_3 - 6.6e-12 45.5 0.0 1.6e-10 41.0 0.0 2.5 2 0 0 2 2 2 1 Helix-hairpin-helix domain DNA_pol_B_palm PF14792.4 MSTRG.24679.1_3 - 9e-11 41.9 0.0 1.8e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta palm NTP_transf_2 PF01909.21 MSTRG.24679.1_3 - 9.3e-06 25.7 0.0 2.2e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain B12-binding_2 PF02607.15 MSTRG.24679.1_3 - 0.021 15.1 0.0 0.21 11.9 0.0 2.2 2 0 0 2 2 2 0 B12 binding domain PTCB-BRCT PF12738.5 MSTRG.24679.1_3 - 0.11 12.3 0.1 0.32 10.8 0.1 1.8 1 0 0 1 1 1 0 twin BRCT domain BRCT PF00533.24 MSTRG.24679.1_3 - 0.11 12.8 0.0 0.26 11.6 0.0 1.6 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.3 MSTRG.24679.1_3 - 0.13 12.4 0.1 0.35 11.1 0.1 1.6 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain HMG_box PF00505.17 MSTRG.9276.1_3 - 3.2e-25 88.2 1.4 6.4e-25 87.2 1.4 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box Sox_N PF12444.6 MSTRG.9276.1_3 - 5.2e-24 85.0 0.9 5.2e-24 85.0 0.9 2.4 2 0 0 2 2 2 1 Sox developmental protein N terminal HMG_box_2 PF09011.8 MSTRG.9276.1_3 - 3.5e-10 40.2 1.2 7.4e-10 39.1 1.2 1.6 1 0 0 1 1 1 1 HMG-box domain Serglycin PF04360.10 MSTRG.9276.1_3 - 0.014 15.2 1.1 0.035 13.9 1.1 1.6 1 0 0 1 1 1 0 Serglycin Oxysterol_BP PF01237.16 MSTRG.22125.1_3 - 9.6e-90 300.9 0.1 1.8e-87 293.5 0.1 2.4 1 1 0 1 1 1 1 Oxysterol-binding protein PH PF00169.27 MSTRG.22125.1_3 - 2e-09 37.8 0.1 6.5e-09 36.1 0.1 1.9 1 0 0 1 1 1 1 PH domain AA_permease_2 PF13520.4 MSTRG.3927.1_2 - 1.2e-47 162.5 30.8 1.2e-47 162.5 30.8 2.2 2 0 0 2 2 2 1 Amino acid permease AA_permease PF00324.19 MSTRG.3927.1_2 - 6.9e-34 117.1 30.6 6.9e-34 117.1 30.6 2.1 2 0 0 2 2 2 1 Amino acid permease AA_permease_C PF13906.4 MSTRG.3927.1_2 - 4.1e-24 84.3 7.3 1.7e-23 82.3 7.3 2.2 1 0 0 1 1 1 1 C-terminus of AA_permease TEP1_N PF05386.9 MSTRG.3231.1_1 - 1.7 8.1 4.6 0.82 9.2 2.2 1.6 2 0 0 2 2 2 0 TEP1 N-terminal domain S100PBPR PF15427.4 MSTRG.1180.1_2 - 1.3e-15 57.5 0.5 2e-15 56.8 0.5 1.2 1 0 0 1 1 1 1 S100P-binding protein iPGM_N PF06415.11 MSTRG.1180.1_2 - 0.057 12.7 0.0 0.095 12.0 0.0 1.2 1 0 0 1 1 1 0 BPG-independent PGAM N-terminus (iPGM_N) Nipped-B_C PF12830.5 MSTRG.5737.2_3 - 1.2e-67 227.4 4.5 4.4e-67 225.6 3.4 2.4 2 0 0 2 2 2 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.5 MSTRG.5737.2_3 - 1.1e-15 57.3 2.6 2.3e-13 49.9 0.3 3.5 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion HEAT_2 PF13646.4 MSTRG.5737.2_3 - 3.4e-06 27.2 0.0 1.8 8.9 0.0 4.3 3 1 1 4 4 4 4 HEAT repeats HEAT PF02985.20 MSTRG.5737.2_3 - 3.9e-05 23.4 3.3 0.084 13.0 0.0 6.3 8 0 0 8 8 8 1 HEAT repeat HEAT_EZ PF13513.4 MSTRG.5737.2_3 - 8.3e-05 22.8 0.0 0.45 10.9 0.0 4.2 4 0 0 4 4 4 2 HEAT-like repeat Cnd1 PF12717.5 MSTRG.5737.2_3 - 0.00013 21.9 6.3 0.16 11.8 1.0 4.1 2 2 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Cnd3 PF12719.5 MSTRG.5737.2_3 - 0.0008 18.6 6.8 0.01 14.9 0.1 3.8 4 2 0 4 4 4 2 Nuclear condensing complex subunits, C-term domain T3SS_basalb_I PF17001.3 MSTRG.5737.2_3 - 0.027 14.9 2.2 0.28 11.7 0.7 3.1 3 0 0 3 3 3 0 Type III secretion basal body protein I, YscI, HrpB, PscI OST-HTH PF12872.5 MSTRG.28606.1_1 - 1.5e-10 40.7 0.0 2e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 OST-HTH/LOTUS domain Abhydrolase_3 PF07859.11 MSTRG.10005.1_2 - 5.9e-55 186.2 0.5 1.5e-39 135.9 0.2 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.26 MSTRG.10005.1_2 - 3.7e-05 22.7 0.6 0.0025 16.7 0.1 2.1 2 0 0 2 2 2 2 Carboxylesterase family Say1_Mug180 PF10340.7 MSTRG.10005.1_2 - 0.009 14.8 0.0 0.013 14.3 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.19 MSTRG.10005.1_2 - 0.023 14.0 0.0 0.051 12.9 0.0 1.5 1 0 0 1 1 1 0 Prolyl oligopeptidase family AXE1 PF05448.10 MSTRG.10005.1_2 - 0.027 13.0 0.0 0.042 12.4 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Pkinase_Tyr PF07714.15 MSTRG.26080.1_2 - 2.9e-46 157.7 0.0 4.6e-46 157.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase KSR1-SAM PF13543.4 MSTRG.26080.1_2 - 3.7e-44 149.8 2.7 6.4e-44 149.1 2.7 1.4 1 0 0 1 1 1 1 SAM like domain present in kinase suppressor RAS 1 Pkinase PF00069.23 MSTRG.26080.1_2 - 1.1e-36 126.4 0.0 1.8e-36 125.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.4 MSTRG.26080.1_2 - 0.0048 16.1 0.0 0.0082 15.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 MSTRG.26080.1_2 - 0.0058 16.1 0.6 0.015 14.7 0.1 1.8 2 0 0 2 2 2 1 RIO1 family C1_1 PF00130.20 MSTRG.26080.1_2 - 0.0072 16.1 14.6 0.0072 16.1 14.6 2.5 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kdo PF06293.12 MSTRG.26080.1_2 - 0.053 12.7 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Mpp10 PF04006.10 MSTRG.26080.1_2 - 0.96 7.7 10.9 1.4 7.2 10.9 1.1 1 0 0 1 1 1 0 Mpp10 protein DUF1619 PF07773.9 MSTRG.3040.1_1 - 5.3e-48 164.5 2.9 3e-45 155.4 0.2 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1619) NPAT_C PF15712.3 MSTRG.4306.1_1 - 3.9e-76 257.1 96.1 3.8e-73 247.2 72.3 5.3 4 1 0 4 4 4 2 NPAT C terminus WD40 PF00400.30 MSTRG.28892.1_1 - 8.5e-06 26.3 0.1 0.0016 19.1 0.1 2.3 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.28892.1_1 - 0.088 13.0 0.0 0.9 9.8 0.0 2.0 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain LRR_6 PF13516.4 MSTRG.18397.1_1 - 3.3e-12 45.3 11.0 0.32 11.0 0.0 7.1 7 0 0 7 7 7 5 Leucine Rich repeat LRR_4 PF12799.5 MSTRG.18397.1_1 - 4e-11 42.8 8.4 6.5e-05 23.1 1.2 5.3 3 2 3 6 6 6 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 MSTRG.18397.1_1 - 0.00079 19.4 9.8 16 6.4 0.0 6.2 5 1 0 5 5 5 2 Leucine Rich Repeat Ste50p-SAM PF09235.8 MSTRG.18397.1_1 - 0.76 9.9 7.4 5.2 7.2 0.2 3.8 3 2 0 3 3 3 0 Ste50p, sterile alpha motif Dimer_Tnp_hAT PF05699.12 MSTRG.23298.2_2 - 0.014 15.1 0.1 0.043 13.5 0.0 1.9 2 0 0 2 2 2 0 hAT family C-terminal dimerisation region Thx PF17070.3 MSTRG.7342.3_2 - 2.3 8.3 8.5 6.1 7.0 8.5 1.7 1 0 0 1 1 1 0 30S ribosomal protein Thx CC2-LZ PF16516.3 MSTRG.7342.3_3 - 7e-13 48.7 13.9 7e-13 48.7 13.9 4.9 3 2 2 5 5 5 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF3138 PF11336.6 MSTRG.7342.3_3 - 0.92 7.9 6.3 0.2 10.1 1.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) SATase_N PF06426.12 MSTRG.7342.3_3 - 2.7 8.3 6.5 1.9 8.8 0.1 3.3 3 1 0 3 3 3 0 Serine acetyltransferase, N-terminal HMG_box PF00505.17 MSTRG.2488.3_1 - 1.5e-50 169.3 58.7 3.3e-16 59.3 3.8 7.2 7 0 0 7 7 7 6 HMG (high mobility group) box HMG_box_5 PF14887.4 MSTRG.2488.3_1 - 1.9e-49 165.5 29.0 1.2e-47 159.6 5.0 4.1 4 0 0 4 4 4 2 HMG (high mobility group) box 5 HMG_box_2 PF09011.8 MSTRG.2488.3_1 - 8.1e-23 80.7 51.8 1e-06 29.1 2.9 6.7 6 0 0 6 6 6 6 HMG-box domain YABBY PF04690.11 MSTRG.2488.3_1 - 0.1 13.0 2.8 0.59 10.6 2.8 2.3 1 0 0 1 1 1 0 YABBY protein DUF1074 PF06382.9 MSTRG.2488.3_1 - 2.6 8.1 24.7 2.3 8.3 0.4 5.5 4 2 2 6 6 6 0 Protein of unknown function (DUF1074) Exo_endo_phos PF03372.21 MSTRG.5986.3_2 - 3.8e-15 56.0 0.0 5.4e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family NPDC1 PF06809.9 MSTRG.5986.3_2 - 0.028 13.3 0.1 0.047 12.6 0.1 1.3 1 0 0 1 1 1 0 Neural proliferation differentiation control-1 protein (NPDC1) TMEM131_like PF12371.6 MSTRG.27484.1_3 - 5.1e-27 93.7 1.1 2.9e-24 84.9 0.7 3.6 3 0 0 3 3 3 1 Transmembrane protein 131-like ASH PF15780.3 MSTRG.27484.1_3 - 2.8e-13 49.7 2.5 5.5e-06 26.4 0.0 5.0 5 0 0 5 5 5 3 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin bZIP_1 PF00170.19 MSTRG.20467.2_1 - 2.8e-08 33.6 11.3 5.4e-08 32.7 11.3 1.5 1 0 0 1 1 1 1 bZIP transcription factor FlaC_arch PF05377.9 MSTRG.20467.2_1 - 0.00096 19.4 1.9 0.00096 19.4 1.9 1.8 2 0 0 2 2 1 1 Flagella accessory protein C (FlaC) bZIP_2 PF07716.13 MSTRG.20467.2_1 - 0.0024 17.8 12.1 0.0026 17.7 9.0 2.6 1 1 1 2 2 2 1 Basic region leucine zipper HAP1_N PF04849.11 MSTRG.20467.2_1 - 0.0093 15.1 3.6 0.014 14.5 3.6 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region DUF4618 PF15397.4 MSTRG.20467.2_1 - 0.013 14.9 4.2 0.018 14.3 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) KLRAQ PF10205.7 MSTRG.20467.2_1 - 0.037 14.1 8.0 0.066 13.3 8.0 1.3 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Cep57_CLD_2 PF14197.4 MSTRG.20467.2_1 - 0.049 13.6 2.3 0.13 12.2 2.3 1.7 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 Kinetocho_Slk19 PF12709.5 MSTRG.20467.2_1 - 0.074 13.4 4.4 0.15 12.4 4.4 1.4 1 0 0 1 1 1 0 Central kinetochore-associated TSC22 PF01166.16 MSTRG.20467.2_1 - 0.075 13.2 4.3 0.16 12.1 2.6 2.1 1 1 1 2 2 2 0 TSC-22/dip/bun family DUF848 PF05852.9 MSTRG.20467.2_1 - 0.16 11.9 4.1 0.28 11.1 4.1 1.3 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) DUF972 PF06156.11 MSTRG.20467.2_1 - 0.22 12.0 4.4 0.44 11.1 4.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) CENP-H PF05837.10 MSTRG.20467.2_1 - 0.27 11.5 7.3 0.27 11.5 5.9 1.6 1 1 0 1 1 1 0 Centromere protein H (CENP-H) ZapB PF06005.10 MSTRG.20467.2_1 - 0.42 11.0 6.9 0.31 11.4 5.0 1.8 1 1 1 2 2 1 0 Cell division protein ZapB bZIP_Maf PF03131.15 MSTRG.20467.2_1 - 0.47 10.9 6.5 0.86 10.0 6.5 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor DivIC PF04977.13 MSTRG.20467.2_1 - 0.65 9.7 6.1 0.43 10.2 3.8 1.8 1 1 1 2 2 2 0 Septum formation initiator eIF3_N PF09440.8 MSTRG.20467.2_1 - 0.74 10.1 3.7 1.6 9.1 3.4 1.6 1 1 0 1 1 1 0 eIF3 subunit 6 N terminal domain CCDC106 PF15794.3 MSTRG.20467.2_1 - 3 7.3 11.8 0.3 10.6 0.8 2.2 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 106 DIL PF01843.17 MSTRG.19593.1_3 - 1.1e-28 99.5 6.2 1.1e-28 99.5 6.2 3.2 3 0 0 3 3 3 1 DIL domain IQ PF00612.25 MSTRG.19593.1_3 - 3.6e-14 51.0 47.3 0.00097 18.6 0.4 7.5 7 0 0 7 7 7 6 IQ calmodulin-binding motif Zip PF02535.20 MSTRG.3526.1_2 - 4.1e-29 101.7 1.9 5.3e-29 101.3 1.9 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter Sugar_tr PF00083.22 MSTRG.26123.3_2 - 2e-25 89.4 14.5 2e-25 89.4 14.5 1.8 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.14 MSTRG.26123.3_2 - 1e-19 70.5 20.9 2.7e-19 69.2 20.9 1.6 1 0 0 1 1 1 1 Major Facilitator Superfamily His_Phos_2 PF00328.20 MSTRG.20561.1_2 - 2.4e-30 106.0 0.0 4.1e-30 105.3 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Clathrin PF00637.18 MSTRG.18904.1_1 - 0.0086 15.8 0.0 0.0098 15.6 0.0 1.1 1 0 0 1 1 1 1 Region in Clathrin and VPS TPR_1 PF00515.26 MSTRG.18904.1_1 - 0.067 12.9 1.9 0.29 10.9 0.1 2.4 2 1 1 3 3 3 0 Tetratricopeptide repeat HECT PF00632.23 MSTRG.26029.1_3 - 6.1e-100 334.5 0.0 8.3e-100 334.1 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.24 MSTRG.26029.1_3 - 2.4e-29 100.8 10.0 4.4e-11 42.4 0.2 3.6 3 0 0 3 3 3 3 WW domain C2 PF00168.28 MSTRG.26029.1_3 - 1.4e-15 57.3 0.0 2.6e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 C2 domain ADH_N PF08240.10 MSTRG.26339.5_3 - 1.3e-06 28.1 0.0 2.3e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.4 MSTRG.26339.5_3 - 9.3e-06 26.6 0.1 3.6e-05 24.7 0.1 1.9 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.24 MSTRG.26339.5_3 - 0.0002 21.1 0.0 0.00037 20.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase SOCS_box PF07525.14 MSTRG.311.2_1 - 0.42 10.9 4.2 0.15 12.3 0.3 2.2 2 0 0 2 2 2 0 SOCS box RAMP PF04901.11 MSTRG.311.2_3 - 1e-35 121.9 0.1 1.9e-35 121.1 0.1 1.5 1 0 0 1 1 1 1 Receptor activity modifying family Ig_2 PF13895.4 MSTRG.3687.2_3 - 3.6e-11 43.1 0.6 4.3e-10 39.7 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.3687.2_3 - 4.2e-09 36.7 0.8 0.0016 18.9 0.1 2.6 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 MSTRG.3687.2_3 - 8.1e-08 32.3 1.7 0.012 15.6 0.3 3.3 3 0 0 3 3 3 2 Immunoglobulin V-set domain I-set PF07679.14 MSTRG.3687.2_3 - 5.2e-06 26.3 0.0 0.033 14.1 0.0 2.8 2 2 0 2 2 2 2 Immunoglobulin I-set domain C2-set_2 PF08205.10 MSTRG.3687.2_3 - 0.0037 17.2 0.6 0.019 14.9 0.0 2.3 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 MSTRG.3687.2_3 - 0.0059 16.9 0.1 2.3 8.6 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin C1-set domain EphA2_TM PF14575.4 MSTRG.3687.2_3 - 0.14 12.8 0.0 0.39 11.4 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain ig PF00047.23 MSTRG.3687.2_3 - 0.21 11.7 3.3 0.76 9.8 0.2 3.1 3 1 0 3 3 3 0 Immunoglobulin domain BolA PF01722.16 MSTRG.25901.5_2 - 1.3e-19 70.1 0.1 2.2e-19 69.4 0.1 1.3 1 0 0 1 1 1 1 BolA-like protein Clathrin PF00637.18 MSTRG.4336.1_3 - 3.2e-202 662.4 37.1 7.1e-33 113.4 1.1 7.8 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_propel PF01394.18 MSTRG.4336.1_3 - 4.8e-49 162.2 2.3 6.8e-09 35.5 0.0 6.6 6 0 0 6 6 6 6 Clathrin propeller repeat Clathrin_H_link PF13838.4 MSTRG.4336.1_3 - 4.2e-31 106.5 0.2 1.5e-30 104.7 0.2 2.1 1 0 0 1 1 1 1 Clathrin-H-link Clathrin-link PF09268.8 MSTRG.4336.1_3 - 2e-14 52.5 0.8 5.4e-14 51.1 0.8 1.8 1 0 0 1 1 1 1 Clathrin, heavy-chain linker Coatomer_WDAD PF04053.12 MSTRG.4336.1_3 - 1.7e-05 23.9 4.7 0.00074 18.6 0.1 3.7 4 0 0 4 4 4 1 Coatomer WD associated region TPR_7 PF13176.4 MSTRG.4336.1_3 - 0.00084 19.1 11.2 1.5 8.9 0.1 7.2 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.4336.1_3 - 0.028 14.1 4.0 1.6 8.6 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.4336.1_3 - 0.12 12.4 6.3 45 4.4 0.0 6.5 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.4336.1_3 - 1.2 9.4 11.0 7.6 6.9 0.0 6.3 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.4336.1_3 - 1.3 9.9 19.7 22 6.1 0.1 8.1 7 1 1 8 8 8 0 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.4336.1_3 - 1.4 9.4 7.9 45 4.5 0.1 5.8 7 2 2 9 9 7 0 Tetratricopeptide repeat DEP PF00610.19 MSTRG.29180.1_1 - 1.5e-12 47.2 0.0 2.7e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RRM_1 PF00076.20 MSTRG.24557.5_3 - 3.9e-08 32.8 0.0 7.4e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 MSTRG.24557.5_3 - 0.19 11.6 0.0 0.32 10.9 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Cation_efflux PF01545.19 MSTRG.8921.1_1 - 1.3e-40 139.1 10.2 1.6e-40 138.9 10.2 1.1 1 0 0 1 1 1 1 Cation efflux family DUF1230 PF06799.9 MSTRG.8921.1_1 - 0.13 12.3 0.7 0.36 10.8 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1230) YdjM PF04307.12 MSTRG.8921.1_1 - 0.45 9.7 7.5 1.8 7.7 7.6 1.9 1 1 0 1 1 1 0 LexA-binding, inner membrane-associated putative hydrolase EMP24_GP25L PF01105.22 MSTRG.23793.1_2 - 1.7e-46 158.4 0.3 2.3e-46 157.9 0.3 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD 7tm_3 PF00003.20 MSTRG.19770.4_1 - 4.9e-42 144.2 2.1 6.3e-42 143.8 2.1 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NEMP PF10225.7 MSTRG.19770.4_1 - 0.00012 21.8 0.7 0.00012 21.8 0.7 1.8 2 0 0 2 2 2 1 NEMP family Dsh_C PF12316.6 MSTRG.19770.4_1 - 0.0026 18.1 5.5 0.0041 17.4 5.5 1.2 1 0 0 1 1 1 1 Segment polarity protein dishevelled (Dsh) C terminal Kei1 PF08552.9 MSTRG.19770.4_1 - 0.034 13.7 0.2 3.2 7.3 0.0 2.2 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 Phage_GPO PF05929.9 MSTRG.19770.4_1 - 0.048 13.2 2.7 0.079 12.5 2.7 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase TMF_TATA_bd PF12325.6 MSTRG.19770.4_1 - 0.061 13.4 7.3 0.11 12.6 7.3 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DP PF08781.8 MSTRG.19770.4_1 - 0.25 11.1 4.6 0.39 10.5 4.6 1.3 1 0 0 1 1 1 0 Transcription factor DP DUF2975 PF11188.6 MSTRG.19770.4_1 - 0.77 9.5 4.2 1.5 8.6 4.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2975) DUF4407 PF14362.4 MSTRG.19770.4_1 - 8.4 5.5 7.4 8.3 5.5 6.7 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Meis_PKNOX_N PF16493.3 MSTRG.10854.3_1 - 3.2e-36 123.4 0.3 6.4e-36 122.4 0.3 1.5 1 0 0 1 1 1 1 N-terminal of Homeobox Meis and PKNOX1 Homeobox_KN PF05920.9 MSTRG.10854.3_1 - 1.7e-19 69.2 1.0 3.5e-19 68.3 1.0 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 MSTRG.10854.3_1 - 1.3e-07 31.2 0.2 2.4e-07 30.3 0.2 1.5 1 0 0 1 1 1 1 Homeobox domain Peptidase_C1 PF00112.21 MSTRG.8671.3_1 - 1.7e-49 168.7 0.3 2e-49 168.5 0.3 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.13 MSTRG.8671.3_1 - 0.00011 21.0 0.1 0.00015 20.6 0.1 1.1 1 0 0 1 1 1 1 Peptidase C1-like family Cystatin PF00031.19 MSTRG.12103.1_1 - 1.9e-13 50.3 0.0 3.1e-06 27.2 0.0 2.3 2 0 0 2 2 2 2 Cystatin domain HrpB1_HrpK PF09613.8 MSTRG.3283.1_3 - 0.089 12.3 0.1 0.12 11.8 0.1 1.2 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB1_HrpK) OTU PF02338.17 MSTRG.26504.1_1 - 1.3e-36 125.7 0.1 3e-36 124.6 0.1 1.6 2 0 0 2 2 2 1 OTU-like cysteine protease zf-RanBP PF00641.16 MSTRG.26504.1_1 - 7.8e-06 25.0 36.5 0.0009 18.4 6.9 3.9 3 0 0 3 3 3 3 Zn-finger in Ran binding protein and others ZF-HD_dimer PF04770.10 MSTRG.26504.1_1 - 3 8.1 8.9 7.5 6.8 0.1 3.0 3 0 0 3 3 3 0 ZF-HD protein dimerisation region PPTA PF01239.20 MSTRG.4900.1_1 - 0.81 9.4 5.8 2.2 8.0 0.4 2.5 2 0 0 2 2 2 0 Protein prenyltransferase alpha subunit repeat DUF4211 PF13926.4 MSTRG.4900.1_1 - 1.7 8.6 5.2 0.27 11.2 1.3 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4211) PRY PF13765.4 MSTRG.4900.1_3 - 2.2e-12 46.3 1.0 6.6e-12 44.7 0.0 2.5 3 0 0 3 3 2 1 SPRY-associated domain zf-C3HC4 PF00097.23 MSTRG.4900.1_3 - 7.4e-11 41.6 5.1 7.4e-11 41.6 5.1 3.0 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 MSTRG.4900.1_3 - 2.3e-10 40.3 29.2 3.1e-07 30.3 8.0 3.6 3 0 0 3 3 3 2 B-box zinc finger zf-RING_UBOX PF13445.4 MSTRG.4900.1_3 - 1.1e-09 38.0 3.6 1.1e-09 38.0 3.6 2.7 2 1 1 3 3 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 MSTRG.4900.1_3 - 1.3e-09 37.6 7.8 1.3e-09 37.6 7.8 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 MSTRG.4900.1_3 - 9.9e-09 35.1 8.0 9.9e-09 35.1 8.0 3.1 3 1 1 4 4 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 MSTRG.4900.1_3 - 3e-07 30.0 8.0 3e-07 30.0 8.0 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.4900.1_3 - 4.3e-07 30.0 8.4 4.3e-07 30.0 8.4 3.0 3 0 0 3 3 3 1 Ring finger domain U-box PF04564.13 MSTRG.4900.1_3 - 3.3e-06 27.0 0.0 0.00022 21.2 0.0 2.5 2 0 0 2 2 2 1 U-box domain zf-RING_5 PF14634.4 MSTRG.4900.1_3 - 9.4e-06 25.4 4.8 9.4e-06 25.4 4.8 3.2 3 0 0 3 3 3 1 zinc-RING finger domain Prok-RING_4 PF14447.4 MSTRG.4900.1_3 - 0.00062 19.5 10.9 0.00062 19.5 10.9 3.4 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 SPRY PF00622.26 MSTRG.4900.1_3 - 0.072 13.1 0.0 0.28 11.2 0.0 2.0 2 0 0 2 2 2 0 SPRY domain zf-Nse PF11789.6 MSTRG.4900.1_3 - 0.097 12.4 3.2 0.22 11.2 3.2 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.4 MSTRG.4900.1_3 - 0.28 11.0 6.3 0.9 9.3 6.3 1.9 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_5 PF17121.3 MSTRG.4900.1_3 - 2.2 8.1 6.3 13 5.7 6.3 2.4 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF1664 PF07889.10 MSTRG.4900.1_3 - 2.7 7.9 7.2 4.3 7.2 0.2 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) PTB PF08416.11 MSTRG.6990.1_3 - 7e-36 123.1 0.0 1.1e-35 122.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotyrosine-binding domain SH2 PF00017.22 MSTRG.6990.1_3 - 3.6e-09 36.4 0.0 9.5e-09 35.1 0.0 1.8 2 0 0 2 2 2 1 SH2 domain FH2 PF02181.21 MSTRG.21069.1_2 - 8.3e-108 360.7 11.0 8.3e-108 360.7 11.0 2.3 2 0 0 2 2 2 2 Formin Homology 2 Domain Drf_FH3 PF06367.14 MSTRG.21069.1_2 - 8.9e-59 198.2 2.9 8.9e-59 198.2 2.9 2.8 3 0 0 3 3 3 1 Diaphanous FH3 Domain Drf_GBD PF06371.11 MSTRG.21069.1_2 - 3.2e-50 170.2 0.0 3.2e-50 170.2 0.0 3.5 3 0 0 3 3 3 1 Diaphanous GTPase-binding Domain DUF2931 PF11153.6 MSTRG.17752.1_1 - 0.14 11.7 0.0 0.15 11.6 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2931) zf-RING_UBOX PF13445.4 MSTRG.2848.1_1 - 3.6e-09 36.4 2.7 3.6e-09 36.4 2.7 3.8 4 1 0 4 4 4 1 RING-type zinc-finger zf-B_box PF00643.22 MSTRG.2848.1_1 - 1.3e-08 34.7 22.6 5.8e-07 29.4 8.3 5.5 5 1 0 5 5 5 2 B-box zinc finger zf-C3HC4 PF00097.23 MSTRG.2848.1_1 - 7.1e-06 25.7 4.2 7.1e-06 25.7 4.2 4.6 5 2 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 MSTRG.2848.1_1 - 0.00032 20.7 5.6 0.00032 20.7 5.6 4.5 5 0 0 5 5 5 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.4 MSTRG.2848.1_1 - 0.00063 19.5 6.2 0.00063 19.5 6.2 4.5 3 2 1 4 4 4 1 zinc-RING finger domain Snapin_Pallidin PF14712.4 MSTRG.2848.1_1 - 0.0038 17.5 0.1 0.0073 16.6 0.1 1.4 1 0 0 1 1 1 1 Snapin/Pallidin Prok-RING_4 PF14447.4 MSTRG.2848.1_1 - 0.0057 16.4 3.9 0.0057 16.4 3.9 4.3 4 0 0 4 4 4 1 Prokaryotic RING finger family 4 TolA_bind_tri PF16331.3 MSTRG.2848.1_1 - 0.11 12.4 0.4 0.11 12.4 0.4 1.7 2 0 0 2 2 2 0 TolA binding protein trimerisation Peptidase_C2 PF00648.19 MSTRG.4082.1_1 - 9.2e-133 441.7 0.2 1.2e-132 441.3 0.2 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 MSTRG.4082.1_1 - 7.1e-51 172.1 0.0 1.2e-50 171.3 0.0 1.4 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_1 PF00036.30 MSTRG.4082.1_1 - 7e-10 37.6 2.7 0.00016 20.8 0.2 3.4 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.4 MSTRG.4082.1_1 - 2.3e-09 36.3 0.6 0.0014 18.3 0.0 4.4 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.4 MSTRG.4082.1_1 - 1.5e-07 31.0 1.1 4.7e-05 23.0 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.4 MSTRG.4082.1_1 - 0.0001 22.5 5.9 0.017 15.4 0.2 3.1 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.4082.1_1 - 0.034 13.5 2.2 6.4 6.3 0.1 3.4 4 0 0 4 4 4 0 EF hand WD40 PF00400.30 MSTRG.4082.1_3 - 1.1e-44 149.3 7.6 2.2e-09 37.6 0.0 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.13 MSTRG.4082.1_3 - 2.1e-27 95.9 0.0 3.1e-27 95.3 0.0 1.3 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.5 MSTRG.4082.1_3 - 7.9e-10 38.8 0.0 0.00061 19.9 0.0 3.5 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 MSTRG.4082.1_3 - 0.13 11.4 0.0 7 5.7 0.0 2.6 1 1 2 3 3 3 0 WD40-like domain BRCT PF00533.24 MSTRG.1114.1_2 - 2.7e-12 46.8 0.0 6.9e-10 39.1 0.0 2.3 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.3 MSTRG.1114.1_2 - 4.2e-06 26.4 0.0 4.4e-05 23.2 0.0 2.1 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.3 MSTRG.1114.1_2 - 0.00021 21.5 0.0 0.004 17.4 0.0 2.2 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain PIN_4 PF13638.4 MSTRG.4231.2_2 - 1.9e-28 99.2 0.0 1.9e-28 99.2 0.0 3.6 4 0 0 4 4 4 1 PIN domain WD40 PF00400.30 MSTRG.29705.1_2 - 2.3e-13 50.2 1.6 3.7e-06 27.4 0.7 3.8 3 0 0 3 3 3 3 WD domain, G-beta repeat eIF2A PF08662.9 MSTRG.29705.1_2 - 0.086 12.6 0.1 0.18 11.5 0.1 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A ATP-grasp_2 PF08442.8 MSTRG.8571.2_2 - 1.4e-70 236.8 0.3 2.1e-70 236.3 0.3 1.3 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.17 MSTRG.8571.2_2 - 1.6e-25 89.5 1.2 2.5e-25 89.0 1.2 1.3 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.4 MSTRG.8571.2_2 - 7.7e-09 35.2 0.1 1.4e-08 34.4 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.17 MSTRG.8571.2_2 - 0.082 12.5 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain CPSase_L_D2 PF02786.15 MSTRG.8571.2_2 - 0.37 10.1 1.2 1.3 8.3 0.3 2.0 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Brix PF04427.16 MSTRG.26865.1_1 - 4.4e-33 114.9 0.6 6.3e-33 114.4 0.6 1.2 1 0 0 1 1 1 1 Brix domain Synuclein PF01387.15 MSTRG.15105.1_2 - 4.1e-18 65.7 5.2 6.3e-18 65.1 5.2 1.2 1 0 0 1 1 1 1 Synuclein Rap_GAP PF02145.13 MSTRG.14371.1_2 - 2.1e-48 164.2 0.0 5.6e-48 162.9 0.0 1.7 1 0 0 1 1 1 1 Rap/ran-GAP UQ_con PF00179.24 MSTRG.23524.1_1 - 3.6e-15 55.7 0.0 4.8e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Ribosomal_L20 PF00453.16 MSTRG.13952.1_1 - 2.9e-37 126.9 3.1 3.9e-37 126.4 3.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L20 SH3_1 PF00018.26 MSTRG.27042.1_1 - 0.0022 17.4 0.1 0.0032 16.9 0.1 1.2 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.27042.1_1 - 0.031 14.0 0.1 0.047 13.4 0.1 1.2 1 0 0 1 1 1 0 Variant SH3 domain bZIP_2 PF07716.13 MSTRG.10142.1_3 - 1.4e-16 60.1 8.3 2.3e-16 59.5 8.3 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.19 MSTRG.10142.1_3 - 0.00032 20.6 7.7 0.00062 19.7 7.7 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.15 MSTRG.10142.1_3 - 0.033 14.6 2.9 0.062 13.7 2.9 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor RhoGEF PF00621.18 MSTRG.22043.2_1 - 1.1e-23 84.3 1.1 1.8e-23 83.6 0.2 1.8 2 0 0 2 2 2 1 RhoGEF domain DUF4675 PF15720.3 MSTRG.22043.2_1 - 7.9e-12 45.2 2.3 1.7e-11 44.1 2.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4675) PH_13 PF16652.3 MSTRG.22043.2_1 - 1.7e-07 31.1 0.1 4.9e-07 29.6 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_5 PF15405.4 MSTRG.22043.2_1 - 0.00023 21.2 0.7 0.003 17.5 0.3 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.27 MSTRG.22043.2_1 - 0.0059 17.0 0.1 0.019 15.3 0.1 1.9 1 1 0 1 1 1 1 PH domain PH_10 PF15411.4 MSTRG.22043.2_1 - 0.037 14.1 0.0 0.11 12.7 0.0 1.8 1 1 0 1 1 1 0 Pleckstrin homology domain EF-hand_3 PF09069.9 MSTRG.19972.8_1 - 5.5e-27 93.9 0.0 2.6e-26 91.7 0.0 2.1 2 0 0 2 2 2 1 EF-hand EF-hand_2 PF09068.9 MSTRG.19972.8_1 - 5.6e-25 87.7 0.2 1.1e-24 86.8 0.2 1.5 1 0 0 1 1 1 1 EF hand ZZ PF00569.15 MSTRG.19972.8_1 - 2e-09 37.0 6.4 4.2e-09 36.0 6.4 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type C1_2 PF03107.14 MSTRG.19972.8_1 - 0.00016 21.8 5.0 0.00039 20.5 5.0 1.7 1 0 0 1 1 1 1 C1 domain Macoilin PF09726.7 MSTRG.19972.8_1 - 0.005 15.3 3.9 0.0071 14.8 3.9 1.1 1 0 0 1 1 1 1 Transmembrane protein DUF4407 PF14362.4 MSTRG.19972.8_1 - 0.039 13.2 3.1 0.058 12.6 3.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CRISPR_Cse2 PF09485.8 MSTRG.19972.8_1 - 0.24 11.8 3.5 0.18 12.2 1.4 1.9 2 0 0 2 2 1 0 CRISPR-associated protein Cse2 (CRISPR_cse2) MerR-DNA-bind PF09278.9 MSTRG.19972.8_1 - 0.34 11.3 6.3 0.43 11.0 4.7 2.0 1 1 1 2 2 2 0 MerR, DNA binding ZapB PF06005.10 MSTRG.19972.8_1 - 0.91 9.9 13.6 5 7.5 0.8 2.5 2 0 0 2 2 2 0 Cell division protein ZapB DivIC PF04977.13 MSTRG.19972.8_1 - 0.99 9.1 6.3 1.4 8.6 0.1 2.5 2 0 0 2 2 2 0 Septum formation initiator Ax_dynein_light PF10211.7 MSTRG.19972.8_1 - 1.3 8.8 6.2 1.8 8.4 1.4 2.8 3 0 0 3 3 3 0 Axonemal dynein light chain Mnd1 PF03962.13 MSTRG.19972.8_1 - 2.4 7.9 5.1 4.7 6.9 5.1 1.4 1 0 0 1 1 1 0 Mnd1 family TSNAXIP1_N PF15739.3 MSTRG.19972.8_1 - 3.2 8.0 5.8 20 5.5 1.0 2.4 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus YlqD PF11068.6 MSTRG.19972.8_1 - 7.5 6.8 7.3 13 6.0 7.3 1.3 1 0 0 1 1 1 0 YlqD protein TPR_2 PF07719.15 MSTRG.11149.2_1 - 6.5e-28 94.4 11.9 1.5e-06 27.7 0.0 9.6 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.11149.2_1 - 8.9e-22 75.3 1.3 0.00014 21.6 0.0 7.4 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.11149.2_1 - 1.4e-20 72.0 3.2 6.6e-05 22.4 0.0 8.9 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.11149.2_1 - 9.1e-17 60.2 17.1 0.00041 20.8 0.0 9.6 6 2 5 11 11 9 3 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.11149.2_1 - 1.6e-13 49.9 6.6 0.15 12.4 0.0 8.1 8 0 0 8 8 7 3 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.11149.2_1 - 1.8e-10 40.8 8.0 0.0001 22.3 1.1 4.5 4 1 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.4 MSTRG.11149.2_1 - 2.9e-10 40.4 10.6 0.22 11.9 0.6 6.8 5 2 2 7 7 6 3 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.11149.2_1 - 3.1e-10 40.5 12.3 0.11 13.0 0.0 6.1 6 1 0 7 7 5 3 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.11149.2_1 - 9.6e-10 38.5 21.9 0.0012 19.0 0.1 7.0 4 1 3 7 7 7 3 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.11149.2_1 - 1.8e-09 37.0 0.1 0.039 13.5 0.0 5.2 3 1 2 5 5 5 3 TPR repeat TPR_9 PF13371.4 MSTRG.11149.2_1 - 1.2e-08 34.9 9.4 0.0028 17.7 0.1 5.2 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.11149.2_1 - 2.6e-05 23.8 0.9 13 6.0 0.0 6.2 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.11149.2_1 - 4.6e-05 23.6 6.4 1.2 9.8 0.0 6.5 7 0 0 7 7 5 1 Tetratricopeptide repeat TPR_15 PF13429.4 MSTRG.11149.2_1 - 5.3e-05 22.4 9.4 0.33 10.0 0.4 4.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.11149.2_1 - 0.00018 21.2 14.3 3.1 7.7 0.1 6.2 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_4 PF07721.12 MSTRG.11149.2_1 - 0.00033 20.9 0.4 5.6 7.8 0.0 4.4 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF3808 PF10300.7 MSTRG.11149.2_1 - 0.00044 19.0 0.0 0.00085 18.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_20 PF14561.4 MSTRG.11149.2_1 - 0.0054 16.9 6.6 14 6.0 0.3 4.7 3 1 1 4 4 4 0 Tetratricopeptide repeat NARP1 PF12569.6 MSTRG.11149.2_1 - 0.15 10.8 0.3 2.2 7.0 0.0 2.6 2 1 1 3 3 3 0 NMDA receptor-regulated protein 1 SPO22 PF08631.8 MSTRG.11149.2_1 - 2.1 7.6 9.7 9.6 5.5 0.3 4.1 4 1 0 5 5 5 0 Meiosis protein SPO22/ZIP4 like TPR_21 PF09976.7 MSTRG.11149.2_1 - 7.6 6.1 11.7 9.4 5.8 0.0 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat-like domain Acyl-CoA_dh_1 PF00441.22 MSTRG.7142.1_3 - 8.8e-36 123.2 2.9 1.3e-35 122.7 2.9 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.17 MSTRG.7142.1_3 - 1.8e-19 69.6 0.0 3e-19 68.9 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.14 MSTRG.7142.1_3 - 5.2e-13 49.5 0.0 9.3e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.9 MSTRG.7142.1_3 - 1.3e-08 35.1 2.9 2.1e-08 34.4 2.9 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain PMSR PF01625.19 MSTRG.15037.1_3 - 4.3e-64 215.2 1.1 5.5e-64 214.8 1.1 1.1 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Pkinase PF00069.23 MSTRG.21615.1_2 - 9e-54 182.5 0.0 1.2e-53 182.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.21615.1_2 - 2.1e-26 92.6 0.0 2.9e-26 92.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.21615.1_2 - 0.00025 20.3 0.0 0.00036 19.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 MSTRG.21615.1_2 - 0.00078 18.7 0.2 0.0013 18.0 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 MSTRG.21615.1_2 - 0.0012 18.3 0.3 0.002 17.6 0.3 1.2 1 0 0 1 1 1 1 RIO1 family MRAP PF15183.4 MSTRG.21615.1_2 - 9.5 6.1 9.4 20 5.1 3.5 2.7 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family CRF-BP PF05428.9 MSTRG.28116.1_1 - 6.6e-27 93.9 0.1 8.2e-27 93.6 0.1 1.1 1 0 0 1 1 1 1 Corticotropin-releasing factor binding protein (CRF-BP) LRR_4 PF12799.5 MSTRG.27244.1_1 - 0.0017 18.6 0.5 0.29 11.5 0.1 2.5 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) Myosin_head PF00063.19 MSTRG.1140.1_3 - 1.7e-112 376.8 6.3 2.5e-112 376.2 6.3 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) PH PF00169.27 MSTRG.1140.1_3 - 7.6e-34 116.3 13.8 6.6e-17 61.8 0.6 5.2 3 1 1 4 4 4 4 PH domain MyTH4 PF00784.15 MSTRG.1140.1_3 - 7.5e-27 93.8 0.2 7.5e-27 93.8 0.2 2.7 2 0 0 2 2 2 1 MyTH4 domain MYO10_CC PF16735.3 MSTRG.1140.1_3 - 1.3e-20 73.0 18.7 1.3e-20 73.0 18.7 4.3 3 1 1 4 4 1 1 Unconventional myosin-X coiled coil domain FERM_M PF00373.16 MSTRG.1140.1_3 - 1e-16 61.3 0.1 1e-16 61.3 0.1 2.2 2 0 0 2 2 1 1 FERM central domain PH_3 PF14593.4 MSTRG.1140.1_3 - 2.5e-11 43.5 1.9 1.5e-06 28.2 0.1 4.0 3 1 0 3 3 3 2 PH domain PH_11 PF15413.4 MSTRG.1140.1_3 - 9e-11 42.0 15.4 0.0067 16.7 3.4 6.2 3 1 1 4 4 4 3 Pleckstrin homology domain PH_8 PF15409.4 MSTRG.1140.1_3 - 3.3e-10 40.0 2.7 4.1e-07 30.0 0.3 3.2 3 0 0 3 3 3 2 Pleckstrin homology domain IQ PF00612.25 MSTRG.1140.1_3 - 0.00011 21.5 9.7 0.054 13.2 0.3 3.9 3 0 0 3 3 3 3 IQ calmodulin-binding motif RA PF00788.21 MSTRG.1140.1_3 - 0.00018 21.9 0.0 0.00065 20.2 0.0 1.9 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PH_9 PF15410.4 MSTRG.1140.1_3 - 0.0042 17.3 2.0 0.033 14.4 0.2 3.3 2 1 0 2 2 2 1 Pleckstrin homology domain PI3_PI4_kinase PF00454.25 MSTRG.1140.1_3 - 0.047 13.4 0.1 0.26 10.9 0.0 2.3 2 0 0 2 2 2 0 Phosphatidylinositol 3- and 4-kinase U79_P34 PF03064.14 MSTRG.1140.1_3 - 0.13 11.4 18.2 0.28 10.4 18.2 1.4 1 0 0 1 1 1 0 HSV U79 / HCMV P34 ARID PF01388.19 MSTRG.26293.2_3 - 2.3e-17 63.3 0.0 4.7e-17 62.3 0.0 1.6 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain CDC45 PF02724.12 MSTRG.26293.2_3 - 3.3 5.8 7.2 4.7 5.3 7.2 1.2 1 0 0 1 1 1 0 CDC45-like protein UPF0149 PF03695.11 MSTRG.26293.2_3 - 4.3 7.5 9.4 8.6 6.5 9.4 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0149) Myotub-related PF06602.12 MSTRG.3848.1_2 - 1.5e-150 500.8 0.0 1.9e-150 500.4 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.18 MSTRG.3848.1_2 - 5.1e-12 45.5 0.0 9.1e-12 44.7 0.0 1.4 1 0 0 1 1 1 1 GRAM domain Y_phosphatase PF00102.25 MSTRG.3848.1_2 - 0.00095 18.7 0.0 0.0016 18.0 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase 3-PAP PF12578.6 MSTRG.3848.1_2 - 0.0031 17.1 0.2 0.0076 15.9 0.2 1.6 1 0 0 1 1 1 1 Myotubularin-associated protein DSPc PF00782.18 MSTRG.3848.1_2 - 0.012 15.3 0.0 0.023 14.3 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 MSTRG.3848.1_2 - 0.19 11.5 0.0 0.3 10.9 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family NYD-SP28_assoc PF14775.4 MSTRG.3848.1_2 - 0.19 11.7 2.5 45 4.1 0.8 3.3 3 0 0 3 3 3 0 Sperm tail C-terminal domain PCNP PF15473.4 MSTRG.3848.1_2 - 0.59 10.7 4.7 1.4 9.5 4.7 1.6 1 0 0 1 1 1 0 PEST, proteolytic signal-containing nuclear protein family Arm PF00514.21 MSTRG.25044.1_3 - 5.5e-23 80.1 11.4 6.8e-09 35.3 0.0 8.5 9 0 0 9 9 9 4 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.18 MSTRG.25044.1_3 - 0.00021 19.9 0.1 0.16 10.3 0.1 2.1 2 0 0 2 2 2 2 Adaptin N terminal region KAP PF05804.10 MSTRG.25044.1_3 - 0.0015 16.6 0.1 0.055 11.5 0.0 2.1 2 0 0 2 2 2 1 Kinesin-associated protein (KAP) DUF383 PF04063.12 MSTRG.25044.1_3 - 0.0033 17.0 0.1 0.18 11.4 0.0 2.6 2 1 1 3 3 3 1 Domain of unknown function (DUF383) HEAT_EZ PF13513.4 MSTRG.25044.1_3 - 0.0054 17.0 0.2 45 4.5 0.0 4.7 5 0 0 5 5 5 0 HEAT-like repeat Atx10homo_assoc PF09759.7 MSTRG.25044.1_3 - 0.01 15.8 3.0 0.023 14.6 0.1 2.7 3 0 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain HEAT_2 PF13646.4 MSTRG.25044.1_3 - 0.022 15.0 0.5 11 6.3 0.2 3.0 2 1 1 3 3 3 0 HEAT repeats LIM PF00412.20 MSTRG.22872.3_1 - 0.48 10.6 13.5 1.1 9.3 13.5 1.7 1 0 0 1 1 1 0 LIM domain Cast PF10174.7 MSTRG.6156.1_1 - 0.001 17.3 7.5 0.001 17.3 7.5 2.1 1 1 1 2 2 2 1 RIM-binding protein of the cytomatrix active zone SlyX PF04102.10 MSTRG.6156.1_1 - 0.0028 18.1 3.9 0.0028 18.1 3.9 5.6 3 1 3 6 6 5 1 SlyX HiaBD2 PF15403.4 MSTRG.6156.1_1 - 0.041 14.2 0.2 0.08 13.2 0.2 1.5 1 0 0 1 1 1 0 HiaBD2_N domain of Trimeric autotransporter adhesin (GIN) IncA PF04156.12 MSTRG.6156.1_1 - 0.064 12.9 31.0 0.019 14.6 23.2 2.3 1 1 1 2 2 2 0 IncA protein ATG16 PF08614.9 MSTRG.6156.1_1 - 0.19 11.7 37.3 0.19 11.7 6.5 2.6 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Ribosomal_S15 PF00312.20 MSTRG.6156.1_1 - 0.29 11.2 9.4 0.14 12.2 0.6 3.1 2 1 1 3 3 3 0 Ribosomal protein S15 YscO PF07321.10 MSTRG.6156.1_1 - 0.34 10.7 32.8 1.3 8.8 4.6 2.8 2 1 1 3 3 3 0 Type III secretion protein YscO Fez1 PF06818.13 MSTRG.6156.1_1 - 1.5 9.1 27.5 0.62 10.4 18.9 2.4 1 1 1 2 2 2 0 Fez1 MAD PF05557.11 MSTRG.6156.1_1 - 5.4 5.1 32.9 0.19 9.9 24.6 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein V_ATPase_I PF01496.17 MSTRG.6156.1_1 - 6.8 4.3 20.0 4.9 4.8 5.6 2.0 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family APG6 PF04111.10 MSTRG.6156.1_1 - 7.5 5.7 28.3 0.51 9.5 15.6 2.1 1 1 1 2 2 2 0 Autophagy protein Apg6 CorA PF01544.16 MSTRG.6156.1_1 - 8.2 5.5 11.8 2.7 7.1 8.6 1.7 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF4407 PF14362.4 MSTRG.6156.1_1 - 9.6 5.3 20.0 6.1 6.0 9.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Ras PF00071.20 MSTRG.7504.1_3 - 5.6e-54 182.0 0.0 7.6e-54 181.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.7504.1_3 - 4e-22 78.6 0.0 6.2e-22 78.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.7504.1_3 - 2.7e-08 33.3 0.0 4e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF2987 PF11205.6 MSTRG.28166.1_3 - 0.019 14.7 0.1 0.024 14.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2987) BP28CT PF08146.10 MSTRG.10121.8_3 - 1.3e-17 64.1 1.9 2.4e-17 63.2 0.2 2.1 2 1 0 2 2 2 1 BP28CT (NUC211) domain HEAT_EZ PF13513.4 MSTRG.10121.8_3 - 0.0046 17.2 0.1 0.041 14.2 0.0 2.3 2 1 1 3 3 3 1 HEAT-like repeat Vac14_Fab1_bd PF12755.5 MSTRG.10121.8_3 - 0.035 14.5 0.1 0.09 13.2 0.1 1.7 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region Pox_RNA_Pol_19 PF05320.10 MSTRG.10121.8_3 - 0.096 12.5 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit PNTB PF02233.14 MSTRG.17427.4_3 - 3.7e-79 266.6 0.2 4.7e-79 266.3 0.2 1.1 1 0 0 1 1 1 1 NAD(P) transhydrogenase beta subunit GIT_CC PF16559.3 MSTRG.12710.1_2 - 0.045 13.7 2.8 0.084 12.8 2.8 1.3 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor RhoGEF PF00621.18 MSTRG.15983.1_3 - 5.8e-43 147.1 1.4 9.5e-43 146.4 1.4 1.4 1 0 0 1 1 1 1 RhoGEF domain SH3_9 PF14604.4 MSTRG.15983.1_3 - 1.3e-10 40.8 0.1 2.7e-10 39.8 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.15983.1_3 - 2.9e-10 39.4 2.1 5.6e-10 38.5 2.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.15983.1_3 - 1.2e-09 37.5 0.1 2.6e-09 36.5 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.27 MSTRG.15983.1_3 - 1.1e-06 28.9 0.2 2.2e-06 28.0 0.2 1.5 1 0 0 1 1 1 1 PH domain Patatin PF01734.20 MSTRG.19628.3_2 - 4.5e-23 82.4 0.2 6.4e-23 81.8 0.2 1.2 1 0 0 1 1 1 1 Patatin-like phospholipase cNMP_binding PF00027.27 MSTRG.19628.3_3 - 1.3e-47 159.6 0.4 5.4e-16 58.3 0.0 3.5 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain TraL PF07178.9 MSTRG.19628.3_3 - 0.071 13.4 0.3 0.19 12.0 0.1 1.8 2 0 0 2 2 2 0 TraL protein AXH PF08517.10 MSTRG.9581.1_1 - 5.8e-41 139.5 0.2 1.1e-40 138.6 0.2 1.4 1 0 0 1 1 1 1 Ataxin-1 and HBP1 module (AXH) ATXN-1_C PF12547.6 MSTRG.9581.1_1 - 1.6e-06 28.2 1.7 1.6e-06 28.2 1.7 4.0 4 0 0 4 4 4 1 Capicua transcriptional repressor modulator BTB PF00651.29 MSTRG.22661.2_3 - 5.5e-20 71.5 0.1 1.1e-19 70.6 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 MSTRG.22661.2_3 - 7.4e-08 32.3 37.9 0.0091 16.3 4.5 5.2 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.22661.2_3 - 1.3e-07 31.7 25.3 0.088 13.6 0.1 4.7 4 0 0 4 4 4 4 C2H2-type zinc finger zf-H2C2_2 PF13465.4 MSTRG.22661.2_3 - 4.7e-05 23.5 2.1 4.7e-05 23.5 2.1 4.4 4 0 0 4 4 4 2 Zinc-finger double domain zf-met PF12874.5 MSTRG.22661.2_3 - 0.00092 19.4 27.6 0.32 11.3 0.7 4.7 4 0 0 4 4 4 4 Zinc-finger of C2H2 type zf-C2HE PF16278.3 MSTRG.22661.2_3 - 0.0025 18.1 16.1 0.6 10.5 0.1 4.4 3 1 0 3 3 3 1 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_jaz PF12171.6 MSTRG.22661.2_3 - 0.13 12.5 19.0 3.2 8.1 0.0 4.8 4 1 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 MSTRG.22661.2_3 - 0.72 10.1 18.4 2.4 8.4 0.4 3.7 2 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) DUF2072 PF09845.7 MSTRG.22661.2_3 - 0.85 9.7 3.2 10 6.2 0.3 2.8 2 0 0 2 2 2 0 Zn-ribbon containing protein TSP_1 PF00090.17 MSTRG.9497.1_3 - 1.3e-08 34.8 9.1 1.3e-08 34.8 9.1 2.0 2 0 0 2 2 2 1 Thrombospondin type 1 domain SLY PF12485.6 MSTRG.2018.2_3 - 1.1e-43 149.5 14.6 1.1e-43 149.5 14.6 3.5 3 1 1 4 4 4 1 Lymphocyte signaling adaptor protein SAM_1 PF00536.28 MSTRG.2018.2_3 - 8.2e-15 54.9 0.0 5.9e-09 36.1 0.0 2.6 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 MSTRG.2018.2_3 - 2.9e-13 49.6 0.0 2e-07 30.9 0.0 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SH3_2 PF07653.15 MSTRG.2018.2_3 - 6.9e-05 22.3 0.0 0.00013 21.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.2018.2_3 - 0.013 15.0 0.0 0.025 14.0 0.0 1.5 1 0 0 1 1 1 0 SH3 domain HR1 PF02185.14 MSTRG.21773.1_1 - 5.9e-50 167.1 28.4 9.4e-18 64.0 7.0 3.3 3 0 0 3 3 3 3 Hr1 repeat Uds1 PF15456.4 MSTRG.21773.1_1 - 0.0013 18.7 17.1 0.031 14.3 2.4 3.2 3 0 0 3 3 3 2 Up-regulated During Septation Pkinase PF00069.23 MSTRG.21773.1_2 - 3.6e-61 206.7 0.0 8.7e-61 205.5 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.21773.1_2 - 2.4e-37 128.5 0.0 3.5e-37 128.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.22 MSTRG.21773.1_2 - 2.9e-09 37.3 0.6 6.2e-09 36.3 0.6 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 MSTRG.21773.1_2 - 1.6e-05 24.3 0.0 2.4e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Tropomodulin PF03250.12 MSTRG.11468.1_2 - 1.3e-58 196.9 6.8 1.9e-58 196.4 6.8 1.2 1 0 0 1 1 1 1 Tropomodulin LRR_6 PF13516.4 MSTRG.11468.1_2 - 0.11 12.5 1.9 0.12 12.3 0.2 2.0 2 0 0 2 2 2 0 Leucine Rich repeat ODV-E18 PF10717.7 MSTRG.24701.1_2 - 0.15 11.8 0.1 0.32 10.8 0.1 1.5 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 TPR_12 PF13424.4 MSTRG.24701.1_3 - 1.7e-46 156.3 55.4 1.1e-12 47.9 2.0 8.3 3 3 2 8 8 8 7 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.24701.1_3 - 1e-39 132.6 28.5 4.7e-07 29.2 0.1 12.0 12 0 0 12 12 12 8 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.24701.1_3 - 1.9e-35 118.1 38.5 6.4e-07 28.8 0.2 12.8 13 0 0 13 13 13 8 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.24701.1_3 - 1.4e-24 84.1 39.8 0.0045 16.9 0.1 13.2 13 0 0 13 13 13 6 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.24701.1_3 - 2.1e-24 84.5 45.1 7.1e-05 22.4 0.2 12.8 13 0 0 13 13 13 6 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.24701.1_3 - 1.7e-18 65.1 23.2 0.00055 19.8 0.2 10.3 11 0 0 11 11 10 4 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.24701.1_3 - 1.3e-08 34.8 33.6 0.025 15.3 0.4 11.5 9 2 3 12 12 12 1 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.24701.1_3 - 4.6e-08 33.5 40.0 8.5e-05 23.0 4.0 8.8 8 1 1 9 9 9 3 Tetratricopeptide repeat Rapsyn_N PF10579.7 MSTRG.24701.1_3 - 5.1e-08 32.8 3.2 2.8 8.0 0.0 7.3 5 2 3 8 8 8 1 Rapsyn N-terminal myristoylation and linker region TPR_17 PF13431.4 MSTRG.24701.1_3 - 7.9e-07 28.9 19.9 0.37 11.1 0.0 7.8 8 0 0 8 8 7 3 Tetratricopeptide repeat DUF3856 PF12968.5 MSTRG.24701.1_3 - 4.7e-06 26.6 19.4 0.00012 22.1 0.4 7.1 2 2 2 6 6 6 1 Domain of Unknown Function (DUF3856) RPN7 PF10602.7 MSTRG.24701.1_3 - 1.3e-05 24.8 4.6 0.32 10.5 0.5 4.3 2 1 2 4 4 4 3 26S proteasome subunit RPN7 TPR_11 PF13414.4 MSTRG.24701.1_3 - 2.1e-05 24.0 28.2 2.2 7.9 0.1 9.7 8 2 1 9 9 9 3 TPR repeat TPR_19 PF14559.4 MSTRG.24701.1_3 - 8.2e-05 22.9 30.4 0.0053 17.1 0.4 7.6 7 1 0 7 7 7 2 Tetratricopeptide repeat DUF4807 PF16065.3 MSTRG.24701.1_3 - 0.005 16.4 10.8 5 6.7 0.3 5.6 3 1 4 7 7 7 1 Domain of unknown function (DUF4807) ANAPC3 PF12895.5 MSTRG.24701.1_3 - 0.0091 16.1 1.2 0.0091 16.1 1.2 4.9 6 2 0 6 6 4 1 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.15 MSTRG.24701.1_3 - 0.013 15.8 0.7 0.013 15.8 0.7 6.0 3 3 3 6 6 6 0 Bacterial transcriptional activator domain TPR_6 PF13174.4 MSTRG.24701.1_3 - 0.019 15.5 17.1 0.29 11.7 0.1 7.2 7 1 0 7 7 6 0 Tetratricopeptide repeat TPR_3 PF07720.10 MSTRG.24701.1_3 - 0.02 14.7 3.5 7.2 6.6 0.1 5.4 6 0 0 6 6 5 0 Tetratricopeptide repeat DUF3446 PF11928.6 MSTRG.24701.1_3 - 0.11 12.7 7.8 0.21 11.8 6.7 2.0 2 0 0 2 2 1 0 Domain of unknown function (DUF3446) Fis1_TPR_C PF14853.4 MSTRG.24701.1_3 - 1.5 8.8 5.6 16 5.5 0.1 4.7 6 1 0 6 6 4 0 Fis1 C-terminal tetratricopeptide repeat ILEI PF15711.3 MSTRG.6664.3_1 - 5.2e-11 42.7 0.1 9.6e-11 41.9 0.1 1.4 1 0 0 1 1 1 1 Interleukin-like EMT inducer DUF1096 PF06493.9 MSTRG.6664.3_3 - 0.075 13.4 5.2 4.7 7.6 1.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1096) zf-C4 PF00105.16 MSTRG.23048.1_3 - 2.7e-32 110.9 16.8 2.7e-32 110.9 16.8 1.9 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 MSTRG.23048.1_3 - 4.5e-22 78.5 0.0 8.2e-22 77.7 0.0 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor PRIMA1 PF16101.3 MSTRG.23048.1_3 - 2.2 8.2 10.8 3 7.8 2.4 2.5 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 GKAP PF03359.11 MSTRG.20332.3_1 - 1.9e-138 461.6 6.4 1.9e-138 461.6 6.4 1.6 2 0 0 2 2 2 1 Guanylate-kinase-associated protein (GKAP) protein Tub PF01167.16 MSTRG.2683.1_2 - 8.3e-80 267.4 0.0 1.6e-79 266.5 0.0 1.5 1 0 0 1 1 1 1 Tub family DUF4337 PF14235.4 MSTRG.2683.1_3 - 3.6 7.5 5.0 0.29 11.1 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) Glyco_hydro_47 PF01532.18 MSTRG.15027.1_1 - 1.2e-150 502.3 0.0 1.4e-150 502.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Nucleoplasmin PF03066.13 MSTRG.20853.3_2 - 3.9e-40 136.3 0.1 9.4e-40 135.1 0.0 1.8 2 0 0 2 2 1 1 Nucleoplasmin/nucleophosmin domain NPM1-C PF16276.3 MSTRG.20853.3_2 - 1e-18 66.9 0.7 2.2e-18 65.8 0.7 1.6 1 0 0 1 1 1 1 Nucleophosmin C-terminal domain Cwf_Cwc_15 PF04889.10 MSTRG.20853.3_2 - 0.0011 18.6 6.9 0.0024 17.5 6.9 1.5 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Nop14 PF04147.10 MSTRG.20853.3_2 - 0.12 10.5 11.7 0.17 9.9 11.7 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.10 MSTRG.20853.3_2 - 0.17 11.1 12.4 0.32 10.2 12.4 1.4 1 0 0 1 1 1 0 NOA36 protein Sigma70_ner PF04546.11 MSTRG.20853.3_2 - 0.63 9.8 8.8 1.4 8.6 8.8 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region Vfa1 PF08432.8 MSTRG.20853.3_2 - 0.91 9.7 12.8 0.46 10.7 9.7 2.0 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 YL1 PF05764.11 MSTRG.20853.3_2 - 1 9.3 15.6 2.1 8.3 15.6 1.4 1 0 0 1 1 1 0 YL1 nuclear protein FAM176 PF14851.4 MSTRG.20853.3_2 - 1.1 8.8 8.8 2.5 7.6 8.8 1.6 1 0 0 1 1 1 0 FAM176 family CENP-B_dimeris PF09026.8 MSTRG.20853.3_2 - 1.4 9.2 20.4 3.7 7.9 20.4 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain CDC45 PF02724.12 MSTRG.20853.3_2 - 1.9 6.6 9.8 2.7 6.1 9.8 1.1 1 0 0 1 1 1 0 CDC45-like protein eIF-3c_N PF05470.10 MSTRG.20853.3_2 - 2.2 6.4 6.6 3.5 5.7 6.6 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Pox_Ag35 PF03286.12 MSTRG.20853.3_2 - 2.8 7.6 15.0 8 6.1 15.0 1.8 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DNA_pol_phi PF04931.11 MSTRG.20853.3_2 - 6.6 4.6 17.9 9.8 4.0 17.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi RR_TM4-6 PF06459.10 MSTRG.20853.3_2 - 7.5 6.2 9.3 16 5.1 9.3 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2541 PF10807.6 MSTRG.28045.1_2 - 0.038 13.9 0.0 0.065 13.2 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2541) Defensin_1 PF00323.17 MSTRG.10199.2_1 - 0.15 12.5 4.2 0.6 10.6 3.0 2.6 2 0 0 2 2 2 0 Mammalian defensin PEHE PF15275.4 MSTRG.10199.2_2 - 3.8e-30 105.0 0.8 3.8e-30 105.0 0.8 3.3 3 1 0 3 3 3 1 PEHE domain DUF2076 PF09849.7 MSTRG.10199.2_2 - 0.16 11.8 3.9 0.071 13.0 0.3 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) FKBP_C PF00254.26 MSTRG.17234.2_3 - 1.2e-27 95.9 0.0 2.2e-27 95.1 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_7 PF13499.4 MSTRG.17234.2_3 - 4.2e-09 36.6 1.6 6.4e-09 36.0 1.6 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.17234.2_3 - 4.6e-06 26.0 2.5 0.034 14.0 0.4 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.4 MSTRG.17234.2_3 - 5.9e-06 25.4 1.8 0.067 12.6 0.6 2.4 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.30 MSTRG.17234.2_3 - 7.2e-05 21.9 5.4 0.0061 15.9 1.5 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.4 MSTRG.17234.2_3 - 0.22 11.2 2.6 12 5.7 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain pair polyprenyl_synt PF00348.15 MSTRG.19224.1_1 - 1.6e-71 240.2 0.0 2.1e-71 239.8 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase HEPPP_synt_1 PF07307.9 MSTRG.19224.1_1 - 0.018 14.6 0.0 0.03 13.8 0.0 1.2 1 0 0 1 1 1 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 Lipase_3 PF01764.23 MSTRG.5821.1_2 - 4.7e-11 42.6 0.0 8.6e-11 41.7 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Ribosomal_S15 PF00312.20 MSTRG.5821.1_2 - 0.15 12.1 0.0 0.29 11.3 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S15 APG6 PF04111.10 MSTRG.13354.1_1 - 0.42 9.8 36.8 1.2 8.4 23.5 2.7 1 1 1 2 2 2 0 Autophagy protein Apg6 NYD-SP28_assoc PF14775.4 MSTRG.13354.1_1 - 1.5 8.8 5.5 7.7 6.6 0.3 2.9 1 1 1 2 2 2 0 Sperm tail C-terminal domain Voldacs PF03517.11 MSTRG.478.1_1 - 0.066 13.2 3.6 0.082 12.9 3.6 1.1 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling EGF_CA PF07645.13 MSTRG.8824.1_3 - 5.7e-49 163.9 77.8 6e-11 42.2 8.5 6.6 6 1 0 6 6 6 6 Calcium-binding EGF domain cEGF PF12662.5 MSTRG.8824.1_3 - 1.2e-34 117.7 38.7 1.5e-11 43.9 2.2 6.2 5 0 0 5 5 5 5 Complement Clr-like EGF-like FXa_inhibition PF14670.4 MSTRG.8824.1_3 - 3.6e-24 84.6 81.6 4.4e-09 36.3 6.6 7.7 6 2 1 7 7 7 4 Coagulation Factor Xa inhibitory site EGF_3 PF12947.5 MSTRG.8824.1_3 - 5.6e-09 35.9 68.4 8.6e-06 25.7 9.2 7.2 6 2 0 6 6 6 4 EGF domain EGF PF00008.25 MSTRG.8824.1_3 - 6.2e-06 26.3 24.8 0.00036 20.6 9.5 8.2 6 2 1 7 7 7 3 EGF-like domain hEGF PF12661.5 MSTRG.8824.1_3 - 0.0058 17.1 7.2 0.0058 17.1 7.2 9.2 8 1 0 8 8 8 4 Human growth factor-like EGF cNMP_binding PF00027.27 MSTRG.3124.2_1 - 3.9e-38 129.2 0.1 2.7e-21 75.3 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.15 MSTRG.3124.2_1 - 3.4e-15 55.3 0.1 6.2e-15 54.4 0.1 1.5 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit DUF781 PF05612.10 MSTRG.3124.2_1 - 0.057 12.4 0.0 0.088 11.8 0.0 1.1 1 0 0 1 1 1 0 Mouse protein of unknown function (DUF781) DUF627 PF04781.10 MSTRG.3124.2_1 - 0.076 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF627) HpcH_HpaI PF03328.12 MSTRG.14787.1_1 - 2.1e-50 170.8 0.0 2.8e-50 170.4 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.4 MSTRG.14787.1_1 - 9.8e-10 38.0 0.1 3.3e-05 23.1 0.0 2.2 1 1 1 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold APS_kinase PF01583.18 MSTRG.14787.1_1 - 0.15 11.8 0.0 1.7 8.4 0.0 2.1 2 0 0 2 2 2 0 Adenylylsulphate kinase MreB_Mbl PF06723.11 MSTRG.10354.1_2 - 0.041 12.6 0.1 0.062 12.0 0.1 1.2 1 0 0 1 1 1 0 MreB/Mbl protein GRAM PF02893.18 MSTRG.4811.2_1 - 2.5e-09 36.8 0.0 3.8e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 GRAM domain Vps36_ESCRT-II PF11605.6 MSTRG.4811.2_1 - 0.0029 17.6 0.0 0.005 16.9 0.0 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 DUF4106 PF13388.4 MSTRG.4811.2_2 - 0.51 9.4 1.4 0.74 8.9 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Nebulin PF00880.16 MSTRG.1479.9_2 - 0 1759.4 620.0 2.6e-10 39.9 2.0 147.3 152 0 0 152 152 152 118 Nebulin repeat Peptidase_M24 PF00557.22 MSTRG.1479.9_2 - 2.5e-18 66.4 3.4 0.29 10.7 0.0 10.9 11 0 0 11 11 11 7 Metallopeptidase family M24 SH3_1 PF00018.26 MSTRG.1479.9_2 - 3.2e-12 45.7 0.0 1.5e-11 43.5 0.0 2.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.1479.9_2 - 3.5e-12 45.8 0.0 7.7e-12 44.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.1479.9_2 - 8.7e-06 25.2 0.0 8.2e-05 22.1 0.0 2.8 2 0 0 2 2 2 1 Variant SH3 domain Toprim_2 PF13155.4 MSTRG.1479.9_2 - 0.26 11.7 2.3 71 3.9 0.0 4.7 4 0 0 4 4 4 0 Toprim-like Oxidored_q2 PF00420.22 MSTRG.1892.1_2 - 0.056 12.9 0.1 0.73 9.4 0.0 2.1 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Antimicrobial25 PF16839.3 MSTRG.1892.1_2 - 0.13 12.2 2.5 0.41 10.6 2.5 1.8 1 0 0 1 1 1 0 Nematode antimicrobial peptide EGF PF00008.25 MSTRG.1892.1_2 - 2.4 8.4 9.8 0.22 11.7 5.1 1.7 2 0 0 2 2 2 0 EGF-like domain NAP PF00956.16 MSTRG.22123.2_1 - 2e-101 338.5 1.5 2e-101 338.5 1.5 1.6 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) RNA_pol_3_Rpc31 PF11705.6 MSTRG.22123.2_1 - 0.014 15.5 10.5 0.014 15.5 10.5 1.6 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Nop14 PF04147.10 MSTRG.22123.2_1 - 0.52 8.3 6.8 0.91 7.5 6.8 1.3 1 0 0 1 1 1 0 Nop14-like family Ferlin_C PF16165.3 MSTRG.24526.4_3 - 1.3e-29 103.0 0.7 9.8e-25 87.2 0.0 2.3 1 1 1 2 2 2 2 Ferlin C-terminus C2 PF00168.28 MSTRG.24526.4_3 - 9.3e-29 99.6 0.0 6.2e-17 61.6 0.0 4.4 3 1 0 3 3 3 3 C2 domain PTEN_C2 PF10409.7 MSTRG.24526.4_3 - 0.039 13.6 0.0 0.093 12.4 0.0 1.5 1 0 0 1 1 1 0 C2 domain of PTEN tumour-suppressor protein Adap_comp_sub PF00928.19 MSTRG.23280.2_2 - 2.5e-80 269.5 0.0 3.3e-80 269.1 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.18 MSTRG.23280.2_2 - 2.1e-05 24.4 0.7 3.6e-05 23.6 0.7 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.7 MSTRG.23280.2_2 - 0.029 13.7 0.0 0.047 13.0 0.0 1.2 1 0 0 1 1 1 0 Muniscin C-terminal mu homology domain Ras PF00071.20 MSTRG.18005.1_2 - 7.6e-48 162.0 0.0 1.4e-47 161.1 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.18005.1_2 - 4.2e-18 65.6 0.0 6.7e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.18005.1_2 - 0.0026 17.1 0.0 0.005 16.2 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family DAGK_acc PF00609.17 MSTRG.6267.4_1 - 6.7e-47 159.6 0.0 1.4e-46 158.6 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.22 MSTRG.6267.4_1 - 1.6e-28 98.7 0.0 3.6e-28 97.6 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Ank_2 PF12796.5 MSTRG.6267.4_1 - 3.6e-13 49.8 0.5 6.4e-13 49.0 0.5 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) C1_1 PF00130.20 MSTRG.6267.4_1 - 2.4e-12 46.4 29.2 1.6e-10 40.6 15.0 2.8 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Ank_4 PF13637.4 MSTRG.6267.4_1 - 3.9e-10 39.9 0.5 8.8e-06 26.0 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.6267.4_1 - 4.4e-10 38.8 0.4 0.0035 17.6 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.4 MSTRG.6267.4_1 - 3e-07 30.5 0.1 0.0066 16.7 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.6267.4_1 - 4.7e-05 23.5 1.4 0.2 12.0 0.2 3.0 3 0 0 3 3 3 2 Ankyrin repeat Kunitz_BPTI PF00014.21 MSTRG.6983.2_1 - 2.7e-54 181.1 34.4 3e-19 68.9 3.6 3.2 3 0 0 3 3 3 3 Kunitz/Bovine pancreatic trypsin inhibitor domain Adaptin_N PF01602.18 MSTRG.16320.5_2 - 3.7e-147 490.9 7.6 4.4e-147 490.7 7.6 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.18 MSTRG.16320.5_2 - 5.4e-10 39.4 0.1 1.1e-09 38.4 0.1 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.5 MSTRG.16320.5_2 - 1.2e-09 38.2 1.1 3.5e-07 30.2 0.0 2.6 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.4 MSTRG.16320.5_2 - 1.1e-05 25.6 1.7 0.042 14.1 0.1 4.5 3 1 0 4 4 4 1 HEAT repeats RIX1 PF08167.10 MSTRG.16320.5_2 - 2e-05 24.3 3.9 0.00064 19.4 0.6 3.5 2 1 0 3 3 3 1 rRNA processing/ribosome biogenesis HEAT PF02985.20 MSTRG.16320.5_2 - 0.0031 17.5 2.0 42 4.6 0.0 4.9 4 0 0 4 4 4 0 HEAT repeat Dymeclin PF09742.7 MSTRG.16320.5_2 - 0.0085 14.5 0.9 0.015 13.7 0.9 1.3 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein DUF1160 PF06648.9 MSTRG.16320.5_2 - 0.029 14.2 2.2 0.081 12.8 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1160) IFRD PF05004.11 MSTRG.16320.5_2 - 0.044 12.8 4.4 0.31 10.0 1.4 2.5 2 0 0 2 2 2 0 Interferon-related developmental regulator (IFRD) DRIM PF07539.10 MSTRG.16320.5_2 - 0.096 10.8 4.9 0.88 7.7 2.5 2.9 1 1 2 3 3 3 0 Down-regulated in metastasis TIP120 PF08623.8 MSTRG.16320.5_2 - 0.12 12.1 1.8 11 5.6 0.2 2.5 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) Spectrin PF00435.19 MSTRG.26464.2_3 - 1e-61 205.8 25.6 4.8e-20 71.9 7.2 4.4 4 0 0 4 4 4 4 Spectrin repeat CH PF00307.29 MSTRG.26464.2_3 - 2.6e-53 178.7 0.9 7.2e-27 93.6 0.0 2.9 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.8 MSTRG.26464.2_3 - 1.4e-25 89.1 0.0 4.7e-25 87.3 0.0 2.0 1 0 0 1 1 1 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.6 MSTRG.26464.2_3 - 4.2e-09 36.0 0.1 4.7e-08 32.6 0.0 2.5 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_1 PF00036.30 MSTRG.26464.2_3 - 2.9e-07 29.4 0.9 0.022 14.2 0.2 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 MSTRG.26464.2_3 - 0.00015 21.3 0.6 0.021 14.6 0.1 2.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.4 MSTRG.26464.2_3 - 0.00024 20.7 0.7 0.0011 18.6 0.3 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.4 MSTRG.26464.2_3 - 0.0004 20.7 0.6 0.0012 19.2 0.1 2.2 2 0 0 2 2 2 1 EF-hand domain pair DUF724 PF05266.12 MSTRG.26464.2_3 - 0.47 10.1 10.9 0.25 11.0 1.8 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF724) ThrE_2 PF12821.5 MSTRG.25033.1_1 - 1.5 8.8 10.0 4.2 7.4 1.1 3.1 2 0 0 2 2 2 0 Threonine/Serine exporter, ThrE Porin_3 PF01459.20 MSTRG.24691.3_3 - 1.2e-81 274.0 8.6 1.5e-81 273.7 8.6 1.1 1 0 0 1 1 1 1 Eukaryotic porin Vert_HS_TF PF06546.9 MSTRG.25724.5_2 - 1.8e-30 106.4 6.8 3.8e-29 102.0 6.8 2.3 1 1 0 1 1 1 1 Vertebrate heat shock transcription factor HSF_DNA-bind PF00447.15 MSTRG.25724.5_2 - 8.8e-25 87.0 1.3 2e-24 85.9 1.3 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding ZapB PF06005.10 MSTRG.25724.5_2 - 0.026 14.8 1.9 0.071 13.4 1.9 1.6 1 0 0 1 1 1 0 Cell division protein ZapB CENP-H PF05837.10 MSTRG.25724.5_2 - 0.27 11.5 5.0 0.091 13.0 2.0 1.7 2 0 0 2 2 2 0 Centromere protein H (CENP-H) C1_1 PF00130.20 MSTRG.2370.1_2 - 4.5e-13 48.7 6.2 6.2e-13 48.3 6.2 1.2 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING-like PF08746.9 MSTRG.2370.1_2 - 0.035 14.3 8.3 0.16 12.2 8.3 2.2 1 1 0 1 1 1 0 RING-like domain PID PF00640.21 MSTRG.2614.2_3 - 2.3e-08 34.0 0.1 4e-08 33.2 0.1 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 MSTRG.2614.2_3 - 0.012 15.7 0.1 0.028 14.4 0.1 1.6 1 0 0 1 1 1 0 Phosphotyrosine-binding domain SH2 PF00017.22 MSTRG.2614.2_3 - 0.069 13.1 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 SH2 domain RhoGAP PF00620.25 MSTRG.6474.2_2 - 5.4e-47 159.3 0.1 1.1e-46 158.3 0.1 1.4 1 0 0 1 1 1 1 RhoGAP domain Collagen PF01391.16 MSTRG.6474.2_2 - 0.32 10.7 1.5 0.56 9.9 1.5 1.3 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) FH2 PF02181.21 MSTRG.15738.1_1 - 3.8e-08 32.7 0.9 5.3e-08 32.2 0.9 1.2 1 0 0 1 1 1 1 Formin Homology 2 Domain Drf_DAD PF06345.9 MSTRG.15738.1_1 - 1.3e-05 24.7 1.2 3.7e-05 23.3 1.2 1.8 1 0 0 1 1 1 1 DRF Autoregulatory Domain FH2 PF02181.21 MSTRG.15738.1_2 - 3e-96 322.7 12.0 3e-96 322.7 12.0 2.1 2 0 0 2 2 2 2 Formin Homology 2 Domain Drf_FH3 PF06367.14 MSTRG.15738.1_2 - 2.2e-16 59.9 0.0 2.2e-16 59.9 0.0 2.3 2 0 0 2 2 2 1 Diaphanous FH3 Domain Drf_FH1 PF06346.10 MSTRG.15738.1_2 - 0.0024 17.5 157.2 0.0024 17.5 157.2 2.4 1 1 1 2 2 2 1 Formin Homology Region 1 OSCP PF00213.16 MSTRG.15738.1_2 - 0.02 14.9 3.8 0.032 14.2 0.7 2.3 2 0 0 2 2 2 0 ATP synthase delta (OSCP) subunit Syntaxin-6_N PF09177.9 MSTRG.15738.1_2 - 1.2 9.6 8.4 2.5 8.6 6.7 2.3 2 0 0 2 2 2 0 Syntaxin 6, N-terminal DUF4407 PF14362.4 MSTRG.15738.1_2 - 1.5 8.0 14.3 2.6 7.2 10.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) MbeD_MobD PF04899.10 MSTRG.15738.1_2 - 2.2 8.3 11.8 3.2 7.8 9.5 2.3 2 0 0 2 2 2 0 MbeD/MobD like DUF3584 PF12128.6 MSTRG.15738.1_2 - 4.5 4.5 19.4 0.035 11.5 11.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) AAA_11 PF13086.4 MSTRG.15738.1_2 - 7.5 6.1 15.2 0.26 10.8 6.7 2.2 2 0 0 2 2 2 0 AAA domain Trypsin PF00089.24 MSTRG.16932.1_1 - 1e-64 218.3 0.2 1.2e-64 218.0 0.2 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 MSTRG.16932.1_1 - 0.00035 21.4 0.0 0.00076 20.2 0.0 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain VIT PF08487.8 MSTRG.29550.1_3 - 1.7e-17 63.6 0.4 2.9e-17 62.8 0.4 1.3 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain Ribosomal_L32p PF01783.21 MSTRG.6431.1_1 - 7.5 6.8 11.9 13 6.0 10.5 2.2 2 0 0 2 2 2 0 Ribosomal L32p protein family ATP-synt_C PF00137.19 MSTRG.6431.1_2 - 2.5e-36 123.7 37.1 4.9e-22 77.9 14.1 2.4 2 0 0 2 2 2 2 ATP synthase subunit C DJ-1_PfpI PF01965.22 MSTRG.21034.4_3 - 2e-48 164.2 0.0 3.2e-48 163.5 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.3 MSTRG.21034.4_3 - 0.00083 19.0 0.0 0.033 13.7 0.0 2.2 1 1 1 2 2 2 2 ThiJ/PfpI family-like zf-H2C2_2 PF13465.4 MSTRG.16735.1_1 - 2.6e-60 198.2 51.1 1.5e-09 37.7 2.3 9.0 9 0 0 9 9 9 8 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.16735.1_1 - 8.6e-37 123.4 63.1 0.0001 22.4 1.6 8.4 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.16735.1_1 - 2.1e-29 99.5 60.9 0.00023 21.6 2.2 8.4 8 0 0 8 8 8 8 C2H2-type zinc finger zf-met PF12874.5 MSTRG.16735.1_1 - 1.1e-07 31.9 56.7 0.00052 20.2 1.5 8.8 8 1 0 8 8 8 3 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.4 MSTRG.16735.1_1 - 1.3e-07 31.1 35.5 0.19 11.4 0.9 7.8 7 0 0 7 7 7 4 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.4 MSTRG.16735.1_1 - 1.1e-06 28.2 66.1 0.11 12.4 0.3 10.0 9 2 0 9 9 9 5 C2H2-type zinc finger C1_2 PF03107.14 MSTRG.16735.1_1 - 6.1e-06 26.3 36.9 4 7.7 0.3 8.3 2 1 6 8 8 8 2 C1 domain zf-UBP PF02148.17 MSTRG.16735.1_1 - 7.3e-06 26.1 27.7 0.15 12.3 5.8 5.1 1 1 3 4 4 4 3 Zn-finger in ubiquitin-hydrolases and other protein zf-Di19 PF05605.10 MSTRG.16735.1_1 - 9.9e-06 25.6 41.6 0.0022 18.1 3.5 5.5 1 1 6 7 7 7 5 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.5 MSTRG.16735.1_1 - 0.0007 19.7 41.3 3.6 7.8 7.7 7.6 1 1 5 6 6 6 1 C2H2 type zinc-finger (2 copies) BolA PF01722.16 MSTRG.16735.1_1 - 0.0023 18.1 15.5 1.4 9.1 0.4 5.9 2 2 4 6 6 6 1 BolA-like protein PHD_4 PF16866.3 MSTRG.16735.1_1 - 0.0038 17.2 27.1 0.71 9.9 2.6 5.2 1 1 3 6 6 6 3 PHD-finger Zn_Tnp_IS1595 PF12760.5 MSTRG.16735.1_1 - 0.0052 16.6 3.5 0.0052 16.6 3.5 5.3 3 1 3 6 6 6 1 Transposase zinc-ribbon domain Trm112p PF03966.14 MSTRG.16735.1_1 - 0.0058 17.0 5.7 1.9 9.0 0.0 4.1 3 1 0 3 3 3 1 Trm112p-like protein LIM PF00412.20 MSTRG.16735.1_1 - 0.0061 16.6 37.7 0.76 9.9 0.2 7.3 2 1 6 8 8 8 1 LIM domain zf-Sec23_Sec24 PF04810.13 MSTRG.16735.1_1 - 0.0067 16.3 25.2 0.1 12.5 0.1 7.6 7 2 2 9 9 8 2 Sec23/Sec24 zinc finger Elf1 PF05129.11 MSTRG.16735.1_1 - 0.008 16.1 36.1 0.14 12.0 1.5 5.0 1 1 5 6 6 6 4 Transcription elongation factor Elf1 like DUF2180 PF09947.7 MSTRG.16735.1_1 - 0.013 15.3 16.3 0.5 10.2 0.9 4.5 2 1 3 5 5 5 0 Uncharacterized protein conserved in archaea (DUF2180) zf-C2H2_11 PF16622.3 MSTRG.16735.1_1 - 0.041 13.5 0.5 0.4 10.4 0.1 7.9 8 0 0 8 8 8 0 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 MSTRG.16735.1_1 - 0.52 11.0 25.8 2 9.1 0.4 4.4 1 1 4 5 5 5 0 zinc-ribbon family ADK_lid PF05191.12 MSTRG.16735.1_1 - 1.7 8.6 24.0 0.69 9.9 0.9 4.8 4 2 0 4 4 4 0 Adenylate kinase, active site lid zf-C2H2_jaz PF12171.6 MSTRG.16735.1_1 - 1.8 8.8 33.6 1.2 9.4 0.1 8.0 8 0 0 8 8 8 0 Zinc-finger double-stranded RNA-binding ROS_MUCR PF05443.9 MSTRG.16735.1_1 - 2.8 7.9 6.7 2.7 7.9 0.1 3.7 3 1 0 4 4 4 0 ROS/MUCR transcriptional regulator protein zf-trcl PF13451.4 MSTRG.16735.1_1 - 2.9 7.7 30.4 19 5.1 0.2 7.8 8 0 0 8 8 8 0 Probable zinc-ribbon domain zf-C2HE PF16278.3 MSTRG.16735.1_1 - 7.7 6.9 42.1 16 5.9 0.2 8.3 1 1 6 7 7 7 0 C2HE / C2H2 / C2HC zinc-binding finger GAGA PF09237.9 MSTRG.16735.1_1 - 8.7 6.1 10.2 9.4 6.0 0.1 4.1 2 1 1 4 4 4 0 GAGA factor zf-ribbon_3 PF13248.4 MSTRG.16735.1_1 - 9.5 5.7 19.9 6.8 6.1 0.1 6.4 7 0 0 7 7 7 0 zinc-ribbon domain Pkinase PF00069.23 MSTRG.24714.1_1 - 0.021 14.0 0.9 0.028 13.7 0.0 1.6 2 0 0 2 2 2 0 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.7027.1_3 - 2.8e-97 324.9 0.0 3.6e-97 324.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.7027.1_3 - 1.1e-50 172.4 0.0 1.5e-50 171.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 MSTRG.7027.1_3 - 1.3e-23 82.7 0.0 2.5e-23 81.8 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 MSTRG.7027.1_3 - 1.2e-13 50.2 0.0 2.5e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.7027.1_3 - 1.1e-08 34.6 0.0 2.2e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.7027.1_3 - 0.00044 19.7 0.0 0.00079 18.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Peptidase_C26 PF07722.11 MSTRG.1933.2_2 - 1.8e-17 63.7 0.0 4.7e-17 62.3 0.0 1.6 1 1 0 1 1 1 1 Peptidase C26 GATase PF00117.26 MSTRG.1933.2_2 - 0.0067 16.1 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Stomoxyn PF11585.6 MSTRG.7967.2_2 - 1.9 8.4 4.0 3.9 7.4 4.0 1.4 1 0 0 1 1 1 0 Insect antimicrobial peptide, stomoxyn HMG_box PF00505.17 MSTRG.7967.2_3 - 1.2e-25 89.6 2.0 2.5e-25 88.5 2.0 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box Sox_N PF12444.6 MSTRG.7967.2_3 - 2.9e-25 89.0 0.1 2.9e-25 89.0 0.1 2.3 2 0 0 2 2 2 1 Sox developmental protein N terminal HMG_box_2 PF09011.8 MSTRG.7967.2_3 - 1.3e-09 38.4 1.2 2.5e-09 37.5 1.2 1.5 1 0 0 1 1 1 1 HMG-box domain DSPc PF00782.18 MSTRG.6091.1_2 - 1.5e-06 27.9 0.0 2.4e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 MSTRG.6091.1_2 - 1.9e-06 27.5 0.0 3e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase RHD_dimer PF16179.3 MSTRG.17369.2_1 - 1.8e-26 92.1 0.1 1.8e-26 92.1 0.1 2.2 2 0 0 2 2 2 1 Rel homology dimerisation domain TIG PF01833.22 MSTRG.17369.2_1 - 0.00059 19.7 0.0 0.0023 17.9 0.0 2.1 1 0 0 1 1 1 1 IPT/TIG domain V_ATPase_I PF01496.17 MSTRG.17369.2_1 - 0.43 8.3 10.2 0.67 7.6 10.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.4 MSTRG.17369.2_1 - 1.1 8.5 13.5 1.8 7.7 13.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.13 MSTRG.17369.2_1 - 8.7 5.7 17.3 19 4.5 17.3 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit Toxin_2 PF00451.17 MSTRG.17369.2_2 - 0.38 11.0 5.3 1.6 9.0 5.3 2.1 1 0 0 1 1 1 0 Scorpion short toxin, BmKK2 PL48 PF15903.3 MSTRG.26631.1_1 - 2.6e-161 536.3 0.6 2.6e-161 536.3 0.6 1.6 2 0 0 2 2 2 1 Filopodia upregulated, FAM65 HEAT_2 PF13646.4 MSTRG.26631.1_1 - 0.00038 20.7 1.6 0.0018 18.5 1.7 2.1 1 1 0 1 1 1 1 HEAT repeats RasGEF_N_2 PF14663.4 MSTRG.26631.1_1 - 0.035 14.3 0.1 0.093 13.0 0.1 1.7 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Sushi PF00084.18 MSTRG.18678.1_1 - 1.2e-36 124.9 26.9 5.4e-10 39.6 1.3 4.4 4 0 0 4 4 4 4 Sushi repeat (SCR repeat) CUB PF00431.18 MSTRG.18678.1_1 - 4.9e-20 71.8 0.0 9.8e-20 70.8 0.0 1.5 1 0 0 1 1 1 1 CUB domain DUF4448 PF14610.4 MSTRG.18678.1_1 - 0.0071 16.0 0.0 0.018 14.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) cEGF PF12662.5 MSTRG.18678.1_1 - 0.43 10.4 8.1 8 6.4 0.3 4.3 4 0 0 4 4 4 0 Complement Clr-like EGF-like CD225 PF04505.10 MSTRG.27150.1_1 - 9.1e-21 73.6 1.1 1.6e-20 72.8 1.1 1.4 1 0 0 1 1 1 1 Interferon-induced transmembrane protein MAP7 PF05672.9 MSTRG.15368.7_3 - 3.6e-23 82.0 19.8 5.1e-23 81.4 19.8 1.2 1 0 0 1 1 1 1 MAP7 (E-MAP-115) family DUF1525 PF07511.9 MSTRG.15368.7_3 - 0.1 12.6 0.7 0.15 12.1 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1525) Neur_chan_memb PF02932.14 MSTRG.15368.7_3 - 0.24 11.3 2.5 0.35 10.7 2.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Phe_ZIP PF08916.9 MSTRG.1939.1_2 - 2.1e-21 76.2 1.9 4.5e-21 75.2 1.9 1.6 1 0 0 1 1 1 1 Phenylalanine zipper SH2 PF00017.22 MSTRG.1939.1_2 - 3e-15 55.9 0.2 6.3e-15 54.9 0.2 1.6 1 0 0 1 1 1 1 SH2 domain PH PF00169.27 MSTRG.1939.1_2 - 2.1e-07 31.3 0.0 4.5e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_2 PF08458.8 MSTRG.1939.1_2 - 0.21 11.8 0.1 0.4 10.9 0.1 1.3 1 0 0 1 1 1 0 Plant pleckstrin homology-like region WD40 PF00400.30 MSTRG.614.5_2 - 7.9e-05 23.2 1.6 0.22 12.3 0.1 2.7 3 0 0 3 3 3 2 WD domain, G-beta repeat Lectin_N PF03954.12 MSTRG.614.5_2 - 0.17 11.5 1.5 0.27 10.8 1.5 1.2 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain Adeno_E3_CR1 PF02440.13 MSTRG.4278.1_3 - 0.046 13.4 1.7 0.07 12.8 1.7 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR1 fn3 PF00041.19 MSTRG.24855.3_3 - 1.6e-72 239.7 10.4 8.6e-15 54.7 0.2 5.5 5 0 0 5 5 5 5 Fibronectin type III domain I-set PF07679.14 MSTRG.24855.3_3 - 3.4e-46 155.1 0.0 2.9e-16 59.2 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.24855.3_3 - 2.4e-43 146.5 0.4 1.6e-13 50.9 0.0 4.8 5 0 0 5 5 4 3 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.24855.3_3 - 2.2e-24 85.5 0.0 1.6e-08 34.6 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 MSTRG.24855.3_3 - 3e-17 62.4 0.0 0.00011 22.2 0.0 3.9 4 0 0 4 4 4 3 Immunoglobulin domain Pur_ac_phosph_N PF16656.3 MSTRG.24855.3_3 - 4.2e-16 59.2 4.8 0.015 15.7 0.2 6.0 5 0 0 5 5 5 4 Purple acid Phosphatase, N-terminal domain V-set PF07686.15 MSTRG.24855.3_3 - 2.3e-11 43.7 0.8 0.17 11.9 0.0 6.6 5 3 0 6 6 6 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 MSTRG.24855.3_3 - 2.2e-09 37.1 0.1 0.063 13.2 0.0 3.8 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain Interfer-bind PF09294.8 MSTRG.24855.3_3 - 6.3e-09 36.0 0.0 0.075 13.2 0.0 5.1 5 0 0 5 5 5 2 Interferon-alpha/beta receptor, fibronectin type III fn3_2 PF16893.3 MSTRG.24855.3_3 - 5.9e-08 32.6 0.0 0.006 16.6 0.0 4.1 5 0 0 5 5 5 2 Fibronectin type III domain Ig_5 PF16681.3 MSTRG.24855.3_3 - 1.6e-07 31.5 0.0 0.052 13.8 0.0 3.5 3 0 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C1-set PF07654.13 MSTRG.24855.3_3 - 0.00088 19.6 0.3 4.2 7.8 0.0 3.9 4 0 0 4 4 3 1 Immunoglobulin C1-set domain fn3_4 PF16794.3 MSTRG.24855.3_3 - 0.021 14.6 0.1 40 4.1 0.0 4.4 4 1 0 4 4 4 0 Fibronectin-III type domain ICAM_N PF03921.12 MSTRG.24855.3_3 - 0.066 12.8 0.0 0.21 11.2 0.0 1.9 1 0 0 1 1 1 0 Intercellular adhesion molecule (ICAM), N-terminal domain zf-CSL PF05207.11 MSTRG.26798.1_3 - 1.7e-22 78.8 2.1 1.7e-22 78.8 2.1 1.7 2 0 0 2 2 2 1 CSL zinc finger Qua1 PF16274.3 MSTRG.6711.2_2 - 5.9e-20 70.9 2.9 1.3e-19 69.8 2.9 1.6 1 0 0 1 1 1 1 Qua1 domain Sam68-YY PF16568.3 MSTRG.6711.2_2 - 1.5e-10 41.5 35.5 2.6e-10 40.8 35.5 1.4 1 0 0 1 1 1 1 Tyrosine-rich domain of Sam68 KH_1 PF00013.27 MSTRG.6711.2_2 - 1.6e-06 27.7 0.0 3.2e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 KH domain RVT_1 PF00078.25 MSTRG.6711.2_3 - 0.0081 15.6 0.1 0.012 15.0 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Adap_comp_sub PF00928.19 MSTRG.27298.2_2 - 1.3e-35 123.0 0.1 1.8e-35 122.5 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.18 MSTRG.27298.2_2 - 5.7e-05 22.9 0.4 9.6e-05 22.2 0.4 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain TACC PF05010.12 MSTRG.7754.4_2 - 5.9e-15 55.5 4.6 9.4e-15 54.8 4.6 1.3 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC) Mago-bind PF09282.8 MSTRG.7754.4_2 - 2.6 7.9 5.9 0.37 10.6 0.8 2.0 2 0 0 2 2 2 0 Mago binding DEAD PF00270.27 MSTRG.10541.3_1 - 1.6e-24 86.5 0.8 1.2e-13 51.0 0.1 2.4 1 1 1 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.10541.3_1 - 5.1e-20 71.8 0.0 1.4e-19 70.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-HIT PF04438.14 MSTRG.10541.3_1 - 1.4e-06 28.0 2.1 2.5e-06 27.1 2.1 1.5 1 0 0 1 1 1 1 HIT zinc finger AAA PF00004.27 MSTRG.10541.3_1 - 0.061 13.6 0.2 0.28 11.5 0.1 2.1 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) Toprim_C_rpt PF13368.4 MSTRG.10541.3_1 - 0.085 12.7 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 Topoisomerase C-terminal repeat SecA_DEAD PF07517.12 MSTRG.10541.3_1 - 0.22 10.6 0.8 1.5 7.9 0.0 2.1 2 0 0 2 2 2 0 SecA DEAD-like domain DUF3480 PF11979.6 MSTRG.24990.1_2 - 1.5e-171 570.1 0.0 2e-171 569.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3480) SARA PF11409.6 MSTRG.24990.1_2 - 3.3e-19 68.7 10.5 1.3e-18 66.8 10.5 2.1 1 0 0 1 1 1 1 Smad anchor for receptor activation (SARA) FYVE PF01363.19 MSTRG.24990.1_2 - 2.8e-17 62.5 14.2 2.8e-17 62.5 14.2 2.1 2 0 0 2 2 2 1 FYVE zinc finger DUF3313 PF11769.6 MSTRG.24990.1_2 - 0.075 12.8 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3313) C2 PF00168.28 MSTRG.19796.3_3 - 8.1e-22 77.3 0.0 1.6e-21 76.4 0.0 1.6 1 0 0 1 1 1 1 C2 domain YbjQ_1 PF01906.15 MSTRG.19796.3_3 - 6.2e-06 26.7 2.5 0.029 14.9 0.0 4.1 3 1 0 3 3 3 3 Putative heavy-metal-binding Cathelicidins PF00666.15 MSTRG.2259.1_3 - 0.041 14.1 0.0 0.073 13.3 0.0 1.3 1 0 0 1 1 1 0 Cathelicidin EMP24_GP25L PF01105.22 MSTRG.15876.1_1 - 2.4e-36 125.3 0.1 2.8e-36 125.0 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Cation_ATPase_C PF00689.19 MSTRG.15335.3_3 - 6.3e-45 153.0 4.4 6.3e-45 153.0 4.4 2.4 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.18 MSTRG.15335.3_3 - 9.1e-38 129.6 14.1 4.9e-27 94.5 1.3 2.5 3 0 0 3 3 3 2 E1-E2 ATPase ATP_Ca_trans_C PF12424.6 MSTRG.15335.3_3 - 4.8e-27 94.1 3.8 1.9e-14 53.7 2.1 2.8 1 1 1 2 2 2 2 Plasma membrane calcium transporter ATPase C terminal Cation_ATPase PF13246.4 MSTRG.15335.3_3 - 2.6e-18 65.8 0.0 5.1e-18 64.8 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.24 MSTRG.15335.3_3 - 1.9e-15 56.2 0.0 5.6e-15 54.6 0.0 1.9 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.24 MSTRG.15335.3_3 - 6e-14 52.7 0.1 8.3e-13 49.0 0.1 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.10 MSTRG.15335.3_3 - 0.00017 21.3 0.7 0.00017 21.3 0.7 3.0 2 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase Afi1 PF07792.10 MSTRG.15335.3_3 - 0.41 11.0 4.3 1 9.7 4.3 1.6 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Sec62 PF03839.14 MSTRG.15335.3_3 - 0.79 9.0 6.2 1.7 8.0 6.2 1.5 1 0 0 1 1 1 0 Translocation protein Sec62 XAP5 PF04921.12 MSTRG.15335.3_3 - 2.9 7.6 11.1 5.9 6.5 11.1 1.4 1 0 0 1 1 1 0 XAP5, circadian clock regulator DUF1510 PF07423.9 MSTRG.15335.3_3 - 2.9 7.1 12.5 8 5.7 12.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CDC45 PF02724.12 MSTRG.15335.3_3 - 3.7 5.6 10.7 5.9 4.9 10.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Plasmod_MYXSPDY PF07981.9 MSTRG.5476.1_3 - 0.15 12.0 0.9 0.21 11.6 0.0 1.7 2 0 0 2 2 2 0 Plasmodium repeat_MYXSPDY PLAC9 PF15205.4 MSTRG.14665.1_2 - 4.1e-06 27.0 0.0 8.8e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Placenta-specific protein 9 Pkinase_Tyr PF07714.15 MSTRG.9912.1_1 - 1.7e-95 319.1 0.0 2.3e-95 318.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.9912.1_1 - 3.4e-42 144.5 0.0 6.5e-42 143.6 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.4 MSTRG.9912.1_1 - 1.8e-41 140.5 0.3 1.5e-13 51.0 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 MSTRG.9912.1_1 - 6.7e-41 138.1 0.0 1.4e-14 53.8 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.9912.1_1 - 1.3e-26 92.6 0.4 3.2e-08 33.7 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Kringle PF00051.16 MSTRG.9912.1_1 - 7.6e-23 80.5 4.4 1.7e-22 79.4 4.4 1.6 1 0 0 1 1 1 1 Kringle domain ig PF00047.23 MSTRG.9912.1_1 - 1.8e-21 75.9 0.0 1.6e-06 28.0 0.0 3.7 3 1 0 3 3 3 3 Immunoglobulin domain Fz PF01392.20 MSTRG.9912.1_1 - 6.4e-17 62.1 1.0 1.5e-16 60.9 1.0 1.7 1 0 0 1 1 1 1 Fz domain C2-set_2 PF08205.10 MSTRG.9912.1_1 - 2.4e-09 37.0 0.1 0.016 15.2 0.0 4.0 3 1 1 4 4 4 3 CD80-like C2-set immunoglobulin domain V-set PF07686.15 MSTRG.9912.1_1 - 1e-05 25.5 2.2 7 6.7 0.0 5.7 3 3 1 4 4 4 1 Immunoglobulin V-set domain Herpes_gE PF02480.14 MSTRG.9912.1_1 - 0.0015 17.2 0.1 0.015 14.0 0.1 2.1 2 0 0 2 2 2 1 Alphaherpesvirus glycoprotein E PRIMA1 PF16101.3 MSTRG.9912.1_1 - 0.021 14.7 0.2 0.07 13.0 0.2 1.9 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CD34_antigen PF06365.10 MSTRG.9912.1_1 - 0.18 11.3 0.1 0.34 10.4 0.1 1.4 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF4231 PF14015.4 MSTRG.9912.1_1 - 0.38 11.1 2.2 0.32 11.4 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Thrombin_light PF09396.8 MSTRG.9912.1_3 - 0.16 11.7 0.5 0.33 10.7 0.5 1.5 1 0 0 1 1 1 0 Thrombin light chain DUF4707 PF15806.3 MSTRG.11949.1_2 - 0.0016 17.3 0.1 0.002 17.0 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4707) Nop14 PF04147.10 MSTRG.27468.2_1 - 0.026 12.7 11.9 0.038 12.1 11.9 1.2 1 0 0 1 1 1 0 Nop14-like family bZIP_1 PF00170.19 MSTRG.27468.2_1 - 0.11 12.4 8.7 0.25 11.4 8.7 1.5 1 0 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.13 MSTRG.27468.2_1 - 0.46 10.5 7.1 1.3 9.0 7.1 1.8 1 0 0 1 1 1 0 Basic region leucine zipper Sporozoite_P67 PF05642.9 MSTRG.27468.2_1 - 3.3 5.5 7.0 5 5.0 7.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CDC45 PF02724.12 MSTRG.27468.2_1 - 3.4 5.7 11.5 2.6 6.1 10.0 1.6 2 0 0 2 2 2 0 CDC45-like protein KH_1 PF00013.27 MSTRG.26250.1_1 - 3.7e-07 29.7 0.0 9.1e-07 28.5 0.0 1.7 2 0 0 2 2 2 1 KH domain S1 PF00575.21 MSTRG.26250.1_1 - 1.3e-05 25.3 0.0 2.2e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 S1 RNA binding domain Xpo1 PF08389.10 MSTRG.24177.1_1 - 5.5e-26 91.3 3.4 1.9e-23 83.1 0.0 4.5 4 1 1 5 5 5 2 Exportin 1-like protein IFRD PF05004.11 MSTRG.24177.1_1 - 0.011 14.8 0.5 0.72 8.8 0.0 2.5 2 0 0 2 2 2 0 Interferon-related developmental regulator (IFRD) Vac14_Fab1_bd PF12755.5 MSTRG.24177.1_1 - 0.078 13.4 0.0 34 5.0 0.0 3.3 1 1 1 2 2 2 0 Vacuolar 14 Fab1-binding region HEAT PF02985.20 MSTRG.24177.1_1 - 1.1 9.6 6.1 1.8e+02 2.7 0.7 5.9 6 0 0 6 6 6 0 HEAT repeat LSM14 PF12701.5 MSTRG.26164.5_2 - 4e-30 103.6 0.0 5e-30 103.3 0.0 1.1 1 0 0 1 1 1 1 Scd6-like Sm domain SM-ATX PF14438.4 MSTRG.26164.5_2 - 5.8e-08 32.6 0.0 8.1e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain LIM PF00412.20 MSTRG.20050.1_3 - 3.3e-14 52.7 23.8 1.2e-07 31.7 8.3 2.5 2 0 0 2 2 2 2 LIM domain Yos1 PF08571.8 MSTRG.16572.2_1 - 7.2e-23 80.5 0.1 1.2e-22 79.8 0.1 1.3 1 0 0 1 1 1 1 Yos1-like Ada_Zn_binding PF02805.14 MSTRG.16572.2_2 - 0.0078 16.1 2.2 1.7 8.6 0.2 3.3 3 0 0 3 3 3 3 Metal binding domain of Ada MMS19_C PF12460.6 MSTRG.462.2_3 - 1.1e-92 311.2 2.4 1.1e-92 311.2 2.4 3.4 2 1 0 3 3 3 1 RNAPII transcription regulator C-terminal MMS19_N PF14500.4 MSTRG.462.2_3 - 1.1e-13 51.2 14.2 4.4e-12 46.0 0.0 5.1 3 2 2 5 5 5 2 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_2 PF13646.4 MSTRG.462.2_3 - 0.00011 22.4 7.8 0.042 14.1 1.3 5.3 4 0 0 4 4 4 1 HEAT repeats RTP1_C1 PF10363.7 MSTRG.462.2_3 - 0.0035 17.4 5.7 3.5 7.7 0.0 5.0 5 1 1 6 6 6 2 Required for nuclear transport of RNA pol II C-terminus 1 MMS22L_C PF14911.4 MSTRG.462.2_3 - 0.049 12.6 0.7 0.1 11.6 0.7 1.4 1 0 0 1 1 1 0 S-phase genomic integrity recombination mediator, C-terminal HEAT PF02985.20 MSTRG.462.2_3 - 0.48 10.7 18.1 27 5.2 0.1 8.4 8 0 0 8 8 8 0 HEAT repeat UDP-g_GGTase PF06427.9 MSTRG.14944.1_1 - 0 1195.8 0.4 0 1195.5 0.4 1.0 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Glyco_transf_8 PF01501.18 MSTRG.14944.1_1 - 1.8e-05 24.3 0.3 4.2e-05 23.1 0.3 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 8 FAM177 PF14774.4 MSTRG.11150.4_3 - 1.1e-46 157.8 0.9 1.8e-46 157.1 0.9 1.4 1 0 0 1 1 1 1 FAM177 family DUF3824 PF12868.5 MSTRG.11150.4_3 - 0.015 15.8 2.9 0.026 15.1 2.9 1.3 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) Zona_pellucida PF00100.21 MSTRG.20650.1_2 - 3.6e-36 125.1 0.7 5.7e-36 124.4 0.7 1.3 1 0 0 1 1 1 1 Zona pellucida-like domain fn3 PF00041.19 MSTRG.20650.1_2 - 5.2e-12 45.8 0.0 0.0051 17.0 0.0 4.6 4 0 0 4 4 4 3 Fibronectin type III domain EGF_CA PF07645.13 MSTRG.20650.1_2 - 2.5e-07 30.6 2.2 6.5e-07 29.3 2.2 1.7 1 0 0 1 1 1 1 Calcium-binding EGF domain EGF_MSP1_1 PF12946.5 MSTRG.20650.1_2 - 1.2e-05 25.1 2.9 2.9e-05 23.9 2.9 1.6 1 0 0 1 1 1 1 MSP1 EGF domain 1 EGF_3 PF12947.5 MSTRG.20650.1_2 - 0.011 15.7 4.6 0.011 15.7 4.6 2.0 2 0 0 2 2 2 0 EGF domain EGF PF00008.25 MSTRG.20650.1_2 - 0.21 11.8 5.7 0.38 11.0 4.1 2.5 2 0 0 2 2 2 0 EGF-like domain FXa_inhibition PF14670.4 MSTRG.20650.1_2 - 1.1 9.5 5.4 2.6 8.3 5.4 1.6 1 0 0 1 1 1 0 Coagulation Factor Xa inhibitory site hEGF PF12661.5 MSTRG.20650.1_2 - 1.4 9.6 6.8 2.5 8.8 4.8 2.6 2 0 0 2 2 2 0 Human growth factor-like EGF VWC PF00093.16 MSTRG.27226.1_1 - 4.1e-10 39.7 12.8 6.8e-10 39.0 12.8 1.4 1 0 0 1 1 1 1 von Willebrand factor type C domain BsuBI_PstI_RE PF06616.9 MSTRG.2357.1_2 - 0.0034 16.2 0.1 0.0041 15.9 0.1 1.0 1 0 0 1 1 1 1 BsuBI/PstI restriction endonuclease C-terminus PhdYeFM_antitox PF02604.17 MSTRG.2357.1_2 - 0.04 13.6 0.1 0.052 13.2 0.1 1.2 1 0 0 1 1 1 0 Antitoxin Phd_YefM, type II toxin-antitoxin system HSDR_N_2 PF13588.4 MSTRG.2357.1_2 - 0.074 12.9 0.3 0.097 12.5 0.3 1.2 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) 7tm_2 PF00002.22 MSTRG.1091.2_1 - 3.1e-71 239.4 12.9 4.5e-71 238.9 12.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 MSTRG.1091.2_1 - 8.7e-19 67.5 2.8 8.7e-19 67.5 2.8 2.2 2 0 0 2 2 2 1 Hormone receptor domain DUF2628 PF10947.6 MSTRG.1091.2_1 - 0.74 10.1 4.2 0.59 10.4 1.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2628) DUF356 PF04009.10 MSTRG.1091.2_3 - 0.14 12.3 1.0 0.27 11.4 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF356) Kelch_3 PF13415.4 MSTRG.28901.1_3 - 7e-14 51.5 0.4 2.8e-06 27.3 0.0 3.0 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_4 PF13418.4 MSTRG.28901.1_3 - 5.3e-13 48.6 0.2 4.5e-08 32.8 0.0 2.8 2 1 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.23 MSTRG.28901.1_3 - 9.1e-13 47.4 0.1 1.6e-06 27.5 0.1 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.13 MSTRG.28901.1_3 - 3.4e-12 45.7 0.7 1.8e-06 27.6 0.1 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.4 MSTRG.28901.1_3 - 9.2e-11 41.3 1.8 2.6e-08 33.5 0.2 2.5 2 1 0 2 2 2 2 Kelch motif Kelch_6 PF13964.4 MSTRG.28901.1_3 - 7.4e-08 32.3 2.8 3.6e-05 23.8 0.1 2.5 1 1 1 2 2 2 2 Kelch motif Helicase_C PF00271.29 MSTRG.12201.1_2 - 1.1e-19 70.6 0.0 2.5e-19 69.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain VIGSSK PF14773.4 MSTRG.12201.1_2 - 3.4e-12 46.2 0.4 1.3e-11 44.3 0.4 2.1 1 0 0 1 1 1 1 Helicase-associated putative binding domain, C-terminal ERCC3_RAD25_C PF16203.3 MSTRG.12201.1_2 - 7.9e-08 31.7 0.0 1.7e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase HDA2-3 PF11496.6 MSTRG.12201.1_2 - 3.7e-05 22.9 0.0 9.2e-05 21.6 0.0 1.6 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Phosphorylase PF00343.18 MSTRG.8934.1_1 - 0 1154.2 0.0 0 1154.0 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase DUF1474 PF07342.9 MSTRG.8934.1_1 - 0.12 12.6 0.1 0.35 11.2 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1474) PI31_Prot_N PF11566.6 MSTRG.26626.2_1 - 4e-19 68.8 0.0 5.9e-19 68.3 0.0 1.2 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.9 MSTRG.26626.2_1 - 5.1e-07 30.6 11.2 1.1e-06 29.6 11.2 1.5 1 0 0 1 1 1 1 PI31 proteasome regulator Collagen PF01391.16 MSTRG.6207.1_3 - 1.3e-36 124.0 117.7 6.8e-10 38.4 26.9 4.2 1 1 3 4 4 4 4 Collagen triple helix repeat (20 copies) DCAF15_WD40 PF14939.4 MSTRG.18954.1_1 - 3e-75 252.4 1.7 5e-75 251.7 1.7 1.4 1 0 0 1 1 1 1 DDB1-and CUL4-substrate receptor 15, WD repeat SAF PF08666.10 MSTRG.16647.2_1 - 0.42 11.1 5.6 7.3 7.2 0.1 4.1 4 1 0 4 4 4 0 SAF domain ESM4 PF15952.3 MSTRG.300.1_2 - 2.1 8.6 6.7 4 7.7 6.7 1.5 1 0 0 1 1 1 0 Enhancer of split M4 family Treslin_N PF15292.4 MSTRG.9791.1_1 - 6.9e-295 980.4 16.3 8.9e-295 980.1 16.3 1.1 1 0 0 1 1 1 1 Treslin N-terminus WH2 PF02205.18 MSTRG.2820.1_2 - 3.5e-06 26.5 0.1 7.2e-06 25.5 0.1 1.6 1 0 0 1 1 1 1 WH2 motif WASH_WAHD PF11945.6 MSTRG.2820.1_2 - 0.02 14.3 1.9 0.16 11.3 0.1 2.1 2 0 0 2 2 2 0 WAHD domain of WASH complex Ferritin PF00210.22 MSTRG.21710.3_2 - 5.4e-38 130.0 1.4 7.2e-38 129.6 1.4 1.2 1 0 0 1 1 1 1 Ferritin-like domain Streptin-Immun PF11083.6 MSTRG.21710.3_2 - 0.089 13.1 0.1 0.19 12.0 0.1 1.5 1 0 0 1 1 1 0 Lantibiotic streptin immunity protein Ribosomal_L22 PF00237.17 MSTRG.9068.1_1 - 1.4e-41 141.0 0.1 2.2e-41 140.3 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e C2 PF00168.28 MSTRG.26229.4_2 - 4.5e-96 315.9 0.0 4.7e-20 71.7 0.0 8.5 7 1 0 7 7 7 7 C2 domain FerB PF08150.10 MSTRG.26229.4_2 - 4.7e-32 110.3 0.1 9.9e-32 109.3 0.1 1.6 1 0 0 1 1 1 1 FerB (NUC096) domain Ferlin_C PF16165.3 MSTRG.26229.4_2 - 2e-26 92.6 2.5 2.6e-24 85.8 0.1 2.4 1 1 1 2 2 2 2 Ferlin C-terminus FerI PF08151.10 MSTRG.26229.4_2 - 6.2e-19 67.7 0.6 1.9e-18 66.2 0.6 1.9 1 0 0 1 1 1 1 FerI (NUC094) domain FerA PF08165.9 MSTRG.26229.4_2 - 2.3e-18 65.7 1.2 4.7e-18 64.7 1.2 1.6 1 0 0 1 1 1 1 FerA (NUC095) domain PI3K_C2 PF00792.22 MSTRG.26229.4_2 - 0.00019 21.4 0.0 0.33 10.9 0.0 2.9 2 0 0 2 2 2 2 Phosphoinositide 3-kinase C2 DUF533 PF04391.10 MSTRG.26229.4_2 - 0.048 13.1 0.3 0.082 12.3 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF533) PTEN_C2 PF10409.7 MSTRG.26229.4_2 - 0.065 12.9 0.0 0.24 11.0 0.0 1.9 1 0 0 1 1 1 0 C2 domain of PTEN tumour-suppressor protein zf-RING_2 PF13639.4 MSTRG.12826.1_1 - 4.5e-11 42.7 5.8 4.5e-11 42.7 5.8 3.0 3 0 0 3 3 3 1 Ring finger domain zf-RING_11 PF17123.3 MSTRG.12826.1_1 - 4.1e-10 39.1 3.8 1.3e-09 37.4 3.8 2.0 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.5 MSTRG.12826.1_1 - 3.6e-06 27.0 3.5 1.1e-05 25.5 3.5 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.4 MSTRG.12826.1_1 - 4.8e-06 26.2 5.9 4.8e-06 26.2 5.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.12826.1_1 - 5.9e-06 26.1 5.4 7.6e-06 25.7 2.4 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.23 MSTRG.12826.1_1 - 4.4e-05 23.1 3.2 0.00012 21.7 3.2 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 MSTRG.12826.1_1 - 0.00072 19.3 1.7 0.00072 19.3 1.7 2.6 3 0 0 3 3 3 1 zinc-RING finger domain ubiquitin PF00240.21 MSTRG.22787.5_1 - 4.5e-77 253.6 9.1 4.8e-33 112.6 0.3 3.0 3 0 0 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.6 MSTRG.22787.5_1 - 1.4e-37 127.3 7.3 4.1e-16 58.4 0.5 3.0 3 0 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 MSTRG.22787.5_1 - 1.2e-12 48.0 1.3 0.00034 20.9 0.1 4.1 3 2 0 3 3 3 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 MSTRG.22787.5_1 - 6.9e-11 42.1 1.4 0.012 15.6 0.1 3.7 3 2 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 MSTRG.22787.5_1 - 1e-08 35.6 0.2 0.12 12.8 0.0 3.1 1 1 1 3 3 3 3 DUF2407 ubiquitin-like domain DUF2870 PF11069.6 MSTRG.22787.5_1 - 2.2e-05 24.6 0.2 6.5 7.0 0.0 3.9 3 2 1 4 4 4 2 Protein of unknown function (DUF2870) Methyltrans_RNA PF04452.12 MSTRG.22787.5_1 - 0.00012 21.4 0.3 0.28 10.4 0.0 2.0 2 0 0 2 2 2 2 RNA methyltransferase FERM_f0 PF16511.3 MSTRG.22787.5_1 - 0.0031 17.7 4.8 21 5.4 0.2 4.7 3 2 0 3 3 3 0 N-terminal or F0 domain of Talin-head FERM PI3K_rbd PF00794.16 MSTRG.22787.5_1 - 0.015 15.3 1.9 2.7 8.1 0.1 2.5 2 2 0 2 2 2 0 PI3-kinase family, ras-binding domain ORF11CD3 PF10549.7 MSTRG.22787.5_1 - 0.017 15.1 0.0 18 5.4 0.0 3.8 5 0 0 5 5 5 0 ORF11CD3 domain ProRS-C_2 PF09181.8 MSTRG.22787.5_1 - 0.022 14.7 1.0 4.1 7.5 0.1 2.2 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal PurS PF02700.12 MSTRG.22787.5_1 - 0.048 13.7 0.5 7.8 6.6 0.0 2.3 2 0 0 2 2 2 0 Phosphoribosylformylglycinamidine (FGAM) synthase ACT_5 PF13710.4 MSTRG.22787.5_1 - 0.048 13.4 0.3 13 5.6 0.0 2.4 2 0 0 2 2 2 0 ACT domain DUF3861 PF12977.5 MSTRG.22787.5_1 - 0.085 12.9 0.3 16 5.6 0.0 2.3 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) ACT_4 PF13291.4 MSTRG.22787.5_1 - 0.089 13.3 0.1 7.3 7.1 0.0 2.3 2 0 0 2 2 2 0 ACT domain DUF969 PF06149.10 MSTRG.22787.5_1 - 0.13 11.5 0.0 2.5 7.3 0.0 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF969) Plexin_cytopl PF08337.10 MSTRG.22787.5_1 - 0.48 8.9 3.9 5.3 5.4 0.5 2.7 1 1 0 2 2 2 0 Plexin cytoplasmic RasGAP domain ENOD40 PF08247.9 MSTRG.22787.5_3 - 4.1 7.5 8.5 15 5.7 0.3 3.5 3 0 0 3 3 3 0 ENOD40 protein GRIP PF01465.18 MSTRG.26896.2_1 - 1.1e-13 50.7 0.5 2.8e-13 49.4 0.5 1.8 1 0 0 1 1 1 1 GRIP domain Sec2p PF06428.9 MSTRG.26896.2_1 - 8.6e-05 22.3 7.0 8.6e-05 22.3 7.0 10.2 3 1 4 8 8 8 1 GDP/GTP exchange factor Sec2p 7tm_1 PF00001.19 MSTRG.12438.1_1 - 3.9e-35 121.3 10.8 3.9e-35 121.3 10.8 1.9 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 MSTRG.12438.1_1 - 0.0016 17.7 1.1 0.0016 17.7 1.1 2.4 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw TMEM237 PF15383.4 MSTRG.12438.1_1 - 0.15 10.9 1.5 0.23 10.4 0.6 1.6 1 1 0 1 1 1 0 Transmembrane protein 237 PDR_CDR PF06422.10 MSTRG.12438.1_1 - 0.63 9.9 2.4 1.2 8.9 0.2 2.4 2 0 0 2 2 2 0 CDR ABC transporter PgaD PF13994.4 MSTRG.12438.1_1 - 3.2 7.6 6.7 0.29 10.9 0.2 2.3 3 0 0 3 3 3 0 PgaD-like protein SNF5 PF04855.10 MSTRG.757.1_3 - 1.1e-54 185.6 0.5 6.4e-29 101.3 0.0 2.1 1 1 1 2 2 2 2 SNF5 / SMARCB1 / INI1 DUF1679 PF07914.9 MSTRG.757.1_3 - 0.0057 15.4 0.0 0.0081 14.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) SelP_N PF04592.12 MSTRG.757.1_3 - 0.061 12.6 1.2 0.098 11.9 1.2 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region fn3 PF00041.19 MSTRG.23469.1_2 - 1.9e-76 252.3 4.1 1.5e-16 60.4 0.0 6.4 6 0 0 6 6 6 5 Fibronectin type III domain I-set PF07679.14 MSTRG.23469.1_2 - 1.9e-68 226.4 5.8 5.5e-18 64.7 0.0 7.6 7 0 0 7 7 7 7 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.23469.1_2 - 5.7e-41 138.9 8.2 2.9e-10 40.5 0.0 7.9 8 0 0 8 8 8 6 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.23469.1_2 - 1e-27 96.2 1.7 6.2e-06 26.3 0.0 6.5 7 0 0 7 7 6 5 Immunoglobulin domain ig PF00047.23 MSTRG.23469.1_2 - 4.9e-17 61.8 11.5 0.00032 20.7 0.0 7.6 9 0 0 9 9 7 5 Immunoglobulin domain V-set PF07686.15 MSTRG.23469.1_2 - 6.6e-16 58.3 8.0 0.022 14.7 0.1 8.9 7 3 0 7 7 7 5 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.3 MSTRG.23469.1_2 - 4.3e-09 36.7 8.6 0.39 11.2 0.0 6.9 6 0 0 6 6 6 2 Purple acid Phosphatase, N-terminal domain Tissue_fac PF01108.15 MSTRG.23469.1_2 - 1.6e-05 24.5 0.1 0.6 9.8 0.0 4.7 4 0 0 4 4 4 2 Tissue factor HmuY PF14064.4 MSTRG.23469.1_2 - 0.0017 18.5 0.0 0.0046 17.0 0.0 1.7 1 0 0 1 1 1 1 HmuY protein fn3_2 PF16893.3 MSTRG.23469.1_2 - 0.0046 17.0 0.0 0.57 10.2 0.0 4.2 4 2 0 4 4 4 1 Fibronectin type III domain C2-set_2 PF08205.10 MSTRG.23469.1_2 - 0.039 13.9 8.7 0.92 9.5 0.0 4.6 5 0 0 5 5 4 0 CD80-like C2-set immunoglobulin domain Adeno_E3_CR1 PF02440.13 MSTRG.23469.1_2 - 0.046 13.4 0.5 16 5.2 0.0 3.7 4 0 0 4 4 4 0 Adenovirus E3 region protein CR1 PepSY_2 PF13670.4 MSTRG.23469.1_2 - 0.18 11.7 1.4 5.5 6.9 0.2 3.1 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain DUF3635 PF12330.6 MSTRG.11408.1_2 - 9.2e-20 70.9 0.3 3.7e-19 68.9 0.3 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3635) Pkinase PF00069.23 MSTRG.11408.1_2 - 1.5e-08 34.2 0.1 8.7e-08 31.7 0.1 2.1 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.21 MSTRG.11408.1_2 - 0.19 11.5 0.0 0.34 10.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family PDZ PF00595.22 MSTRG.415.1_2 - 0.011 15.9 0.2 0.13 12.5 0.0 2.1 2 0 0 2 2 2 0 PDZ domain (Also known as DHR or GLGF) BRD4_CDT PF17105.3 MSTRG.415.1_2 - 0.044 13.3 2.3 0.044 13.3 2.3 1.5 2 0 0 2 2 2 0 C-terminal domain of bromodomain protein 4 DUF3915 PF13054.4 MSTRG.12567.1_2 - 0.71 9.7 4.0 1.3 8.9 4.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Ras PF00071.20 MSTRG.12567.1_3 - 5.8e-57 191.7 0.1 7.7e-57 191.3 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.12567.1_3 - 8.8e-31 106.5 0.0 1.5e-30 105.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.12567.1_3 - 1.1e-10 41.1 0.0 1.6e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 MSTRG.12567.1_3 - 3e-07 30.4 0.0 5e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 MSTRG.12567.1_3 - 0.0003 20.6 2.1 0.14 12.0 0.0 2.8 3 0 0 3 3 3 2 Protein of unknown function, DUF258 Gtr1_RagA PF04670.10 MSTRG.12567.1_3 - 0.0033 16.7 0.0 0.0047 16.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF3915 PF13054.4 MSTRG.12567.1_3 - 0.14 12.0 2.1 0.3 10.9 2.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) H_lectin PF09458.8 MSTRG.12567.1_3 - 0.16 12.0 0.5 0.99 9.5 0.1 2.2 2 0 0 2 2 2 0 H-type lectin domain I-set PF07679.14 MSTRG.13531.2_2 - 1.8e-16 59.8 0.0 4.7e-16 58.5 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.13531.2_2 - 2.1e-08 34.5 0.0 5.8e-08 33.1 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 MSTRG.13531.2_2 - 0.00012 22.1 0.1 0.00043 20.3 0.1 2.0 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.13531.2_2 - 0.11 12.7 0.1 0.25 11.6 0.1 1.5 1 0 0 1 1 1 0 Immunoglobulin domain ER PF01133.15 MSTRG.8851.1_2 - 5.3e-44 148.1 0.2 9.9e-44 147.2 0.2 1.5 1 0 0 1 1 1 1 Enhancer of rudimentary zf-CCCH PF00642.22 MSTRG.12452.1_3 - 1.2e-07 31.3 19.1 0.0014 18.4 0.9 4.6 4 0 0 4 4 4 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.3 MSTRG.12452.1_3 - 0.013 15.6 0.9 0.013 15.6 0.9 3.3 4 0 0 4 4 4 0 Zinc-finger containing family zf-CCCH_2 PF14608.4 MSTRG.12452.1_3 - 0.041 14.2 29.1 1.2 9.6 1.4 5.6 5 0 0 5 5 5 0 RNA-binding, Nab2-type zinc finger TFIIB PF00382.17 MSTRG.12155.1_3 - 6.5e-50 166.9 2.4 2.4e-24 85.1 0.2 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.10 MSTRG.12155.1_3 - 3.1e-14 52.1 0.1 5.1e-14 51.4 0.1 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.21 MSTRG.12155.1_3 - 7.3e-08 32.1 0.1 4.1e-06 26.5 0.0 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 MSTRG.12155.1_3 - 0.00037 20.4 0.0 0.24 11.4 0.0 2.3 2 0 0 2 2 2 2 Cyclin, C-terminal domain RB_B PF01857.18 MSTRG.12155.1_3 - 0.0098 15.8 0.2 0.025 14.5 0.1 1.7 2 0 0 2 2 2 1 Retinoblastoma-associated protein B domain Sigma70_r4 PF04545.14 MSTRG.12155.1_3 - 0.043 13.2 0.0 0.27 10.7 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 BTB_2 PF02214.20 MSTRG.437.3_1 - 5.9e-22 77.7 0.1 1.1e-21 76.9 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain GPS2_interact PF15784.3 MSTRG.22852.2_2 - 6.4e-34 116.4 4.3 6.4e-34 116.4 4.3 4.4 4 0 0 4 4 4 1 G-protein pathway suppressor 2-interacting domain Myb_DNA-binding PF00249.29 MSTRG.22852.2_2 - 5.7e-18 64.7 0.5 5.4e-11 42.3 0.2 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 MSTRG.22852.2_2 - 0.026 14.6 2.2 0.14 12.2 0.3 2.6 2 0 0 2 2 2 0 Myb-like DNA-binding domain DUF737 PF05300.9 MSTRG.10161.1_3 - 0.014 15.7 0.9 0.014 15.7 0.9 6.9 3 2 4 7 7 7 0 Protein of unknown function (DUF737) IQ PF00612.25 MSTRG.10161.1_3 - 0.096 12.4 4.3 0.34 10.7 4.3 2.0 1 0 0 1 1 1 0 IQ calmodulin-binding motif LRR_8 PF13855.4 MSTRG.24942.1_1 - 5.3e-44 147.7 20.5 1.8e-12 46.7 0.2 5.1 1 1 4 5 5 5 5 Leucine rich repeat LRR_5 PF13306.4 MSTRG.24942.1_1 - 3e-20 72.4 0.0 1.6e-09 37.7 0.0 2.2 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 MSTRG.24942.1_1 - 6.4e-18 64.4 21.1 0.00015 21.9 1.3 5.7 2 2 3 6 6 6 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 MSTRG.24942.1_1 - 3.2e-08 32.8 19.0 0.26 11.7 0.0 8.2 8 1 0 8 8 8 3 Leucine Rich Repeat LRR_9 PF14580.4 MSTRG.24942.1_1 - 5.8e-07 29.0 3.1 0.0029 17.0 0.4 2.2 2 0 0 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.4 MSTRG.24942.1_1 - 4.1e-05 23.2 21.4 0.15 12.1 0.1 6.7 7 0 0 7 7 7 3 Leucine Rich repeat LRRCT PF01463.22 MSTRG.24942.1_1 - 0.077 13.4 0.3 1.1 9.9 0.0 3.0 3 1 0 3 3 3 0 Leucine rich repeat C-terminal domain DUF2857 PF11198.6 MSTRG.24942.1_1 - 0.097 12.3 1.4 2.5 7.7 0.1 3.2 2 2 2 4 4 4 0 Protein of unknown function (DUF2857) 5-FTHF_cyc-lig PF01812.18 MSTRG.25697.1_1 - 4.5e-52 176.5 0.0 6.2e-52 176.0 0.0 1.2 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family DUF2085 PF09858.7 MSTRG.20182.1_1 - 0.029 14.7 1.0 0.051 13.9 1.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2085) Mito_carr PF00153.25 MSTRG.20182.1_2 - 1.2e-66 220.5 0.9 2e-23 82.0 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein zf-H2C2_2 PF13465.4 MSTRG.38.1_2 - 8.6e-28 95.4 24.4 4.2e-09 36.3 0.3 5.9 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.38.1_2 - 6.9e-19 67.0 32.6 4.5e-05 23.5 0.7 5.0 5 0 0 5 5 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.38.1_2 - 3.1e-13 49.2 30.6 0.00094 19.7 0.7 5.4 5 0 0 5 5 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.38.1_2 - 1.2e-12 47.3 17.6 0.00016 21.4 0.2 4.4 4 0 0 4 4 4 4 C2H2-type zinc finger zf-Di19 PF05605.10 MSTRG.38.1_2 - 6.1e-06 26.3 8.6 0.0034 17.5 1.4 3.2 2 1 1 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.5 MSTRG.38.1_2 - 2e-05 24.6 18.0 0.33 11.3 0.2 4.9 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.4 MSTRG.38.1_2 - 3e-05 23.5 1.7 3e-05 23.5 1.7 4.1 4 0 0 4 4 4 1 C2H2-type zinc-finger domain SprT-like PF10263.7 MSTRG.38.1_2 - 0.011 15.4 0.7 0.011 15.4 0.7 2.8 3 0 0 3 3 3 0 SprT-like family Phage_lysis PF03245.11 MSTRG.38.1_2 - 0.032 14.2 0.4 0.059 13.4 0.4 1.4 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein zf-BED PF02892.13 MSTRG.38.1_2 - 0.2 11.6 18.5 0.045 13.7 1.9 4.2 1 1 3 4 4 4 0 BED zinc finger zf-C4_ClpX PF06689.11 MSTRG.38.1_2 - 0.34 10.7 10.6 17 5.3 0.0 4.4 4 0 0 4 4 4 0 ClpX C4-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.38.1_2 - 3.1 8.1 15.7 18 5.7 0.0 4.9 5 0 0 5 5 4 0 Zinc-finger double-stranded RNA-binding LIM PF00412.20 MSTRG.38.1_2 - 3.8 7.7 20.2 0.7 10.0 1.8 4.5 2 1 3 5 5 5 0 LIM domain zinc_ribbon_15 PF17032.3 MSTRG.38.1_2 - 5.1 7.8 14.7 3.8 8.2 1.1 3.4 2 1 1 3 3 3 0 zinc-ribbon family Filament PF00038.19 MSTRG.10398.1_3 - 1.3e-53 182.5 22.4 1.6e-53 182.2 22.4 1.0 1 0 0 1 1 1 1 Intermediate filament protein AAA_13 PF13166.4 MSTRG.10398.1_3 - 0.0022 16.6 6.3 0.0022 16.6 6.3 1.7 1 1 0 1 1 1 1 AAA domain FPP PF05911.9 MSTRG.10398.1_3 - 0.017 13.3 19.6 0.059 11.5 8.2 2.1 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil DUF3322 PF11795.6 MSTRG.10398.1_3 - 0.041 13.7 6.5 0.068 13.0 1.6 2.8 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) DUF812 PF05667.9 MSTRG.10398.1_3 - 0.044 12.6 20.6 2.3 6.9 20.8 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF812) bZIP_1 PF00170.19 MSTRG.10398.1_3 - 0.046 13.7 7.2 7.5 6.6 0.1 3.8 3 0 0 3 3 3 0 bZIP transcription factor DUF972 PF06156.11 MSTRG.10398.1_3 - 0.21 12.1 15.4 5 7.7 0.1 5.0 3 2 3 6 6 6 0 Protein of unknown function (DUF972) PI3K_P85_iSH2 PF16454.3 MSTRG.10398.1_3 - 0.25 10.8 20.9 0.27 10.7 9.8 3.2 3 1 0 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Spore_III_AB PF09548.8 MSTRG.10398.1_3 - 0.54 10.2 11.7 0.67 9.9 2.7 2.7 2 1 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Metal_resist PF13801.4 MSTRG.10398.1_3 - 0.66 10.0 15.0 0.21 11.6 6.6 2.9 3 0 0 3 3 3 0 Heavy-metal resistance DUF2388 PF09498.8 MSTRG.10398.1_3 - 0.81 9.6 5.6 1.1 9.2 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2388) DUF2730 PF10805.6 MSTRG.10398.1_3 - 0.83 9.6 8.6 15 5.6 0.1 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2730) YkyA PF10368.7 MSTRG.10398.1_3 - 1 9.0 17.2 0.052 13.2 6.2 3.4 3 1 1 4 4 4 0 Putative cell-wall binding lipoprotein FlaC_arch PF05377.9 MSTRG.10398.1_3 - 9.9 6.5 11.3 15 5.9 0.1 4.0 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) ATP-synt_ab PF00006.23 MSTRG.1927.1_3 - 4.4e-75 251.9 0.0 6.6e-75 251.3 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.25 MSTRG.1927.1_3 - 1.9e-46 157.3 3.4 2.8e-46 156.8 3.4 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.21 MSTRG.1927.1_3 - 8.5e-07 29.3 0.0 2.4e-06 27.8 0.0 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF4142 PF13628.4 MSTRG.1927.1_3 - 4.8e-05 23.5 2.6 8.3e-05 22.7 2.6 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4142) ATPase PF06745.11 MSTRG.1927.1_3 - 0.047 12.9 0.1 0.095 11.9 0.1 1.5 1 0 0 1 1 1 0 KaiC DUF4782 PF16016.3 MSTRG.4345.1_1 - 1.5e-37 129.3 1.0 1.5e-37 129.3 1.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4782) GRAM PF02893.18 MSTRG.4345.1_1 - 3.3e-27 94.4 0.1 6.8e-27 93.4 0.1 1.6 1 0 0 1 1 1 1 GRAM domain SKA1 PF07160.10 MSTRG.4345.1_1 - 0.11 12.2 0.9 0.18 11.5 0.1 1.7 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Tyrosinase PF00264.18 MSTRG.27953.1_3 - 6.2e-31 108.3 0.1 1.3e-30 107.2 0.0 1.5 2 0 0 2 2 2 1 Common central domain of tyrosinase Laminin_EGF PF00053.22 MSTRG.27953.1_3 - 0.023 14.7 4.1 0.023 14.7 4.1 3.6 3 0 0 3 3 3 0 Laminin EGF domain MCM_bind PF09739.7 MSTRG.21312.3_1 - 0.19 10.0 1.3 0.28 9.4 1.3 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor RRM_1 PF00076.20 MSTRG.21312.3_3 - 1.6e-12 46.9 0.1 2.7e-12 46.2 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PPP4R2 PF09184.9 MSTRG.21312.3_3 - 0.00096 18.7 17.1 0.0016 18.0 17.1 1.4 1 0 0 1 1 1 1 PPP4R2 Borrelia_P83 PF05262.9 MSTRG.21312.3_3 - 0.0039 15.6 6.6 0.0049 15.3 6.6 1.1 1 0 0 1 1 1 1 Borrelia P83/100 protein IATP PF04568.10 MSTRG.21312.3_3 - 0.0057 16.9 0.1 0.0057 16.9 0.1 1.8 2 0 0 2 2 2 1 Mitochondrial ATPase inhibitor, IATP RRM_5 PF13893.4 MSTRG.21312.3_3 - 0.013 15.0 0.0 0.022 14.2 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Herpes_PAP PF03325.11 MSTRG.21312.3_3 - 0.074 12.0 4.3 0.12 11.3 4.3 1.3 1 0 0 1 1 1 0 Herpesvirus polymerase accessory protein Cwf_Cwc_15 PF04889.10 MSTRG.21312.3_3 - 2.9 7.4 27.0 5.4 6.5 27.0 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein BUD22 PF09073.8 MSTRG.21312.3_3 - 4.3 6.4 29.0 8.8 5.4 29.0 1.5 1 0 0 1 1 1 0 BUD22 TRAPP PF04051.14 MSTRG.17015.1_3 - 1.2e-43 148.2 0.1 1.8e-43 147.6 0.1 1.3 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component MAP7 PF05672.9 MSTRG.23400.1_3 - 3.8e-41 140.4 83.9 3.8e-41 140.4 83.9 4.1 3 1 0 3 3 3 1 MAP7 (E-MAP-115) family ANF_receptor PF01094.26 MSTRG.29638.1_3 - 3.3e-05 23.0 0.0 4.1e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Cadherin_C PF01049.15 MSTRG.1066.1_1 - 1e-49 168.1 0.1 1.9e-49 167.2 0.1 1.4 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin PF00028.15 MSTRG.1066.1_1 - 2e-13 50.5 0.0 1.9e-06 28.1 0.0 2.4 2 0 0 2 2 2 2 Cadherin domain Integrin_alpha2 PF08441.10 MSTRG.230.3_3 - 3.5e-110 368.9 0.0 4.2e-110 368.7 0.0 1.1 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.21 MSTRG.230.3_3 - 2.4e-20 72.2 21.9 1.4e-07 31.4 0.1 5.6 5 0 0 5 5 5 4 FG-GAP repeat VCBS PF13517.4 MSTRG.230.3_3 - 5.7e-13 49.1 5.0 5.2e-07 30.0 0.3 4.5 3 1 1 4 4 4 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.18 MSTRG.230.3_3 - 0.00015 21.4 0.4 0.00015 21.4 0.4 2.2 2 0 0 2 2 2 1 Integrin alpha cytoplasmic region LYRIC PF15686.3 MSTRG.230.3_3 - 0.094 12.1 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family Calcipressin PF04847.10 MSTRG.230.3_3 - 0.1 12.2 0.7 0.21 11.2 0.7 1.4 1 0 0 1 1 1 0 Calcipressin Pkinase PF00069.23 MSTRG.18368.1_1 - 2.5e-25 89.2 0.0 3.1e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.18368.1_1 - 6e-07 28.9 0.0 7.3e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AbLIM_anchor PF16182.3 MSTRG.15406.1_3 - 2.5e-59 201.8 11.1 1.6e-39 136.7 3.8 2.2 1 1 0 2 2 2 2 Putative adherens-junction anchoring region of AbLIM LIM PF00412.20 MSTRG.15406.1_3 - 1e-38 131.2 38.3 2.2e-13 50.1 0.7 4.9 4 1 0 4 4 4 4 LIM domain VHP PF02209.17 MSTRG.15406.1_3 - 1.5e-14 53.6 1.1 3.4e-14 52.5 1.1 1.6 1 0 0 1 1 1 1 Villin headpiece domain V-set PF07686.15 MSTRG.10285.1_2 - 9.4e-07 28.8 0.5 2.1e-05 24.5 0.0 2.6 3 0 0 3 3 3 1 Immunoglobulin V-set domain Ig_3 PF13927.4 MSTRG.10285.1_2 - 3.4e-06 27.4 1.6 0.015 15.8 0.0 3.2 2 1 1 3 3 3 2 Immunoglobulin domain I-set PF07679.14 MSTRG.10285.1_2 - 4.4e-05 23.3 0.0 0.0033 17.3 0.0 2.6 2 1 0 2 2 2 1 Immunoglobulin I-set domain Receptor_2B4 PF11465.6 MSTRG.10285.1_2 - 0.00011 22.3 0.0 0.00021 21.3 0.0 1.5 1 0 0 1 1 1 1 Natural killer cell receptor 2B4 Ig_2 PF13895.4 MSTRG.10285.1_2 - 0.0029 17.8 0.2 0.35 11.1 0.3 2.5 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 MSTRG.10285.1_2 - 0.035 14.1 0.1 15 5.7 0.0 2.6 2 1 0 2 2 2 0 Immunoglobulin domain Syndecan PF01034.18 MSTRG.10285.1_2 - 0.052 13.3 0.1 0.23 11.3 0.1 1.9 2 0 0 2 2 2 0 Syndecan domain IncA PF04156.12 MSTRG.10285.1_2 - 0.099 12.3 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 IncA protein Spc97_Spc98 PF04130.11 MSTRG.10205.1_3 - 2.8e-117 392.6 10.2 7.2e-117 391.3 10.2 1.7 1 1 0 1 1 1 1 Spc97 / Spc98 family P66_CC PF16563.3 MSTRG.24960.3_1 - 5.9e-17 60.9 7.1 5.9e-17 60.9 7.1 3.0 3 0 0 3 3 3 1 Coiled-coil and interaction region of P66A and P66B with MBD2 GATA PF00320.25 MSTRG.24960.3_1 - 1e-06 28.1 6.4 2.4e-06 26.9 6.4 1.7 1 0 0 1 1 1 1 GATA zinc finger FYVE PF01363.19 MSTRG.24960.3_1 - 0.049 13.6 1.8 0.1 12.6 1.8 1.5 1 0 0 1 1 1 0 FYVE zinc finger BON PF04972.15 MSTRG.24960.3_1 - 0.12 12.6 0.1 0.52 10.5 0.1 2.1 1 0 0 1 1 1 0 BON domain DUF3619 PF12279.6 MSTRG.24960.3_1 - 0.36 11.0 4.8 5.9 7.1 3.4 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3619) Myosin_tail_1 PF01576.17 MSTRG.17318.2_1 - 4.6e-48 163.7 164.0 4e-37 127.5 60.4 3.0 1 1 1 2 2 2 2 Myosin tail DUF4201 PF13870.4 MSTRG.17318.2_1 - 0.00019 21.0 15.3 0.00019 21.0 15.3 7.5 2 1 5 7 7 7 1 Domain of unknown function (DUF4201) Spc7 PF08317.9 MSTRG.17318.2_1 - 0.0011 17.8 18.7 0.0011 17.8 18.7 6.3 2 1 4 6 6 6 2 Spc7 kinetochore protein TPR_MLP1_2 PF07926.10 MSTRG.17318.2_1 - 0.007 16.3 23.0 0.007 16.3 23.0 9.1 2 1 8 10 10 10 2 TPR/MLP1/MLP2-like protein Reo_sigmaC PF04582.10 MSTRG.17318.2_1 - 0.014 14.7 40.9 0.18 11.1 3.6 6.1 1 1 2 5 5 5 0 Reovirus sigma C capsid protein Filament PF00038.19 MSTRG.17318.2_1 - 0.019 14.5 142.4 0.15 11.5 16.2 6.9 1 1 4 6 6 6 0 Intermediate filament protein Forkhead PF00250.16 MSTRG.3090.1_3 - 2.1e-25 88.7 0.1 3.7e-25 87.9 0.1 1.4 1 0 0 1 1 1 1 Forkhead domain DSS1_SEM1 PF05160.11 MSTRG.6805.1_3 - 1.6e-22 79.2 19.4 2.2e-22 78.8 19.4 1.2 1 0 0 1 1 1 1 DSS1/SEM1 family Neural_ProG_Cyt PF06567.9 MSTRG.3600.4_1 - 9.4e-18 64.4 2.9 1.8e-17 63.5 2.9 1.4 1 0 0 1 1 1 1 Neural chondroitin sulphate proteoglycan cytoplasmic domain Ribosomal_S17_N PF16205.3 MSTRG.24663.1_1 - 1.1e-25 89.7 0.4 1.6e-25 89.1 0.4 1.2 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17_N PF16205.3 MSTRG.24663.1_3 - 7.6e-14 51.7 0.0 1.2e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal zf-C2H2 PF00096.24 MSTRG.11094.1_2 - 2.8e-22 77.7 33.1 4.5e-06 26.7 0.2 5.4 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.11094.1_2 - 1.1e-21 76.0 30.1 4.8e-08 33.0 0.3 5.5 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.11094.1_2 - 1.7e-13 50.0 27.4 0.0043 17.6 2.5 5.6 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.11094.1_2 - 1.9e-07 31.1 14.1 0.065 13.4 0.1 4.9 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 MSTRG.11094.1_2 - 4.1e-05 23.3 12.7 0.091 12.6 1.8 4.0 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.5 MSTRG.11094.1_2 - 0.00016 21.8 18.1 0.0027 17.9 1.6 4.5 4 0 0 4 4 4 1 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.3 MSTRG.11094.1_2 - 0.00098 19.2 12.0 0.027 14.7 1.6 3.1 1 1 2 3 3 3 3 C2H2-type zinc ribbon FOXP-CC PF16159.3 MSTRG.11094.1_2 - 3.7 8.1 16.1 18 5.9 0.0 4.8 2 2 3 5 5 5 0 FOXP coiled-coil domain I-set PF07679.14 MSTRG.29447.1_3 - 6.1e-17 61.3 0.0 7.6e-17 61.0 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.29447.1_3 - 2.2e-11 44.1 0.0 2.8e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 MSTRG.29447.1_3 - 3.4e-07 30.2 0.0 4.1e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.29447.1_3 - 1.4e-05 25.2 0.0 1.8e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 MSTRG.29447.1_3 - 0.0094 15.9 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 MSTRG.29447.1_3 - 0.04 14.2 0.0 0.051 13.9 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin C1-set domain Thioredoxin PF00085.18 MSTRG.29447.1_3 - 0.1 12.4 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin DUF719 PF05334.11 MSTRG.11388.2_3 - 1.9e-60 204.2 5.7 1.9e-60 204.2 5.7 3.3 2 1 1 3 3 3 1 Protein of unknown function (DUF719) zf-C2H2 PF00096.24 MSTRG.17210.3_3 - 1.9e-19 68.8 33.9 9.9e-05 22.5 1.4 6.0 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.17210.3_3 - 4.6e-10 39.3 28.8 0.034 14.8 0.8 6.0 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.17210.3_3 - 5.1e-09 36.1 26.4 0.0016 18.5 2.9 5.7 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.4 MSTRG.17210.3_3 - 6e-09 35.8 8.8 5e-07 29.7 0.5 5.9 6 0 0 6 6 6 2 Zinc-finger double domain NOA36 PF06524.10 MSTRG.17210.3_3 - 1.2e-05 24.8 18.2 1.2e-05 24.8 18.2 4.2 5 0 0 5 5 5 2 NOA36 protein zf-H2C2_5 PF13909.4 MSTRG.17210.3_3 - 0.00014 21.4 1.3 0.00014 21.4 1.3 4.7 4 0 0 4 4 4 2 C2H2-type zinc-finger domain zf-met PF12874.5 MSTRG.17210.3_3 - 0.0083 16.4 31.5 1.6 9.1 3.4 6.1 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 MSTRG.17210.3_3 - 1.2 9.0 26.1 1.1 9.2 1.0 4.7 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_2 PF12756.5 MSTRG.17210.3_3 - 4.3 7.6 21.7 1.6 9.0 5.3 5.0 3 2 2 5 5 5 0 C2H2 type zinc-finger (2 copies) DZR PF12773.5 MSTRG.17210.3_3 - 8 6.4 14.6 8.7 6.3 2.2 3.6 3 0 0 3 3 3 0 Double zinc ribbon MIF4G PF02854.17 MSTRG.27220.2_2 - 3.5e-62 209.7 12.3 3.5e-62 209.7 12.3 2.6 3 0 0 3 3 3 1 MIF4G domain MA3 PF02847.15 MSTRG.27220.2_2 - 7.4e-22 77.3 0.1 2.8e-21 75.5 0.1 2.1 1 0 0 1 1 1 1 MA3 domain W2 PF02020.16 MSTRG.27220.2_2 - 1.8e-15 56.7 0.3 6.9e-15 54.8 0.3 2.1 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon ATPase PF06745.11 MSTRG.27220.2_2 - 0.12 11.6 0.4 0.27 10.4 0.4 1.5 1 0 0 1 1 1 0 KaiC Josephin PF02099.15 MSTRG.453.1_1 - 1.4e-25 90.1 0.0 1.4e-24 86.8 0.0 2.0 1 1 0 1 1 1 1 Josephin Sortilin-Vps10 PF15902.3 MSTRG.26529.1_3 - 1.4e-103 346.9 0.0 1.7e-103 346.7 0.0 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.3 MSTRG.26529.1_3 - 1.7e-34 119.5 6.1 2.7e-34 118.8 6.1 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal PKD PF00801.18 MSTRG.26529.1_3 - 3.6e-08 33.0 0.1 1.1e-07 31.5 0.1 1.8 1 0 0 1 1 1 1 PKD domain BNR_6 PF15899.3 MSTRG.26529.1_3 - 0.00012 21.7 8.8 0.076 13.0 0.2 5.4 5 0 0 5 5 5 2 BNR-Asp box repeat PSII_BNR PF14870.4 MSTRG.26529.1_3 - 0.004 16.3 0.1 1.3 8.0 0.0 3.2 3 0 0 3 3 3 2 Photosynthesis system II assembly factor YCF48 BNR PF02012.18 MSTRG.26529.1_3 - 0.0069 16.1 17.4 7.3 6.9 0.0 7.6 7 0 0 7 7 7 2 BNR/Asp-box repeat BNR_2 PF13088.4 MSTRG.26529.1_3 - 0.029 13.5 0.1 0.35 10.0 0.0 2.5 2 1 1 3 3 3 0 BNR repeat-like domain CPW_WPC PF09717.8 MSTRG.26529.1_3 - 0.39 11.6 4.7 1.5 9.7 4.7 2.1 1 0 0 1 1 1 0 Plasmodium falciparum domain of unknown function (CPW_WPC) PI-PLC-Y PF00387.17 MSTRG.10025.1_3 - 6.2e-38 129.6 0.1 8.7e-38 129.1 0.1 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.28 MSTRG.10025.1_3 - 5.5e-17 61.8 0.0 1.2e-16 60.7 0.0 1.6 1 0 0 1 1 1 1 C2 domain C2-C2_1 PF11618.6 MSTRG.9777.2_3 - 1.6e-51 174.0 0.0 3.9e-43 146.8 0.0 3.7 3 0 0 3 3 3 2 First C2 domain of RPGR-interacting protein 1 C2 PF00168.28 MSTRG.9777.2_3 - 2.7e-07 30.7 0.0 5.6e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 C2 domain TINF2_N PF14973.4 MSTRG.11709.3_1 - 8.3e-49 165.6 0.7 1.1e-48 165.2 0.7 1.2 1 0 0 1 1 1 1 TERF1-interacting nuclear factor 2 N-terminus zf-H2C2_2 PF13465.4 MSTRG.11709.3_3 - 1.6e-51 170.4 78.2 4.5e-07 29.9 0.7 11.6 11 0 0 11 11 11 10 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.11709.3_3 - 1.2e-46 154.5 84.5 1.1e-05 25.5 0.4 11.7 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.11709.3_3 - 1.8e-33 112.1 89.6 0.0011 19.5 2.0 12.5 12 0 0 12 12 12 11 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.11709.3_3 - 7.4e-19 67.1 64.2 0.0011 18.7 0.7 11.5 11 0 0 11 11 11 8 C2H2-type zinc finger zf-met PF12874.5 MSTRG.11709.3_3 - 3.4e-14 52.6 51.4 0.0025 18.0 0.6 9.9 10 0 0 10 10 10 6 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.11709.3_3 - 1.1e-11 44.6 56.4 0.0048 17.0 0.7 10.9 13 0 0 13 13 13 7 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 MSTRG.11709.3_3 - 0.19 12.0 0.1 0.19 12.0 0.1 4.5 3 2 3 6 6 6 0 zinc-finger-containing domain GAGA PF09237.9 MSTRG.11709.3_3 - 1 9.1 12.8 4.7 7.0 0.0 4.3 3 1 1 4 4 4 0 GAGA factor zf-C2H2_9 PF16293.3 MSTRG.11709.3_3 - 2.3 8.0 9.1 20 5.0 0.2 4.8 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) HypA PF01155.17 MSTRG.11709.3_3 - 2.8 7.9 33.6 13 5.7 3.7 5.6 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ADK_lid PF05191.12 MSTRG.11709.3_3 - 4.2 7.3 26.1 0.33 10.9 1.2 5.5 4 1 0 4 4 4 0 Adenylate kinase, active site lid Zn-ribbon_8 PF09723.8 MSTRG.11709.3_3 - 4.3 7.4 44.8 0.11 12.5 1.0 7.7 5 3 3 8 8 8 0 Zinc ribbon domain O-FucT PF10250.7 MSTRG.564.1_2 - 1.6e-66 225.1 0.0 2e-66 224.8 0.0 1.1 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase RELT PF12606.6 MSTRG.24480.1_3 - 1.3e-20 72.3 0.3 2.3e-20 71.6 0.3 1.4 1 0 0 1 1 1 1 Tumour necrosis factor receptor superfamily member 19 RUN PF02759.17 MSTRG.11183.2_1 - 1.8e-30 105.6 0.3 3.7e-30 104.5 0.0 1.7 2 0 0 2 2 2 1 RUN domain FYVE PF01363.19 MSTRG.11183.2_1 - 5e-07 29.6 1.3 5e-07 29.6 1.3 1.8 2 0 0 2 2 1 1 FYVE zinc finger Trimer_CC PF08954.9 MSTRG.11183.2_1 - 0.00054 19.3 1.2 0.35 10.3 0.4 2.8 2 0 0 2 2 2 2 Trimerisation motif DUF812 PF05667.9 MSTRG.11183.2_1 - 0.0065 15.3 12.3 0.01 14.6 12.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) DUF1664 PF07889.10 MSTRG.11183.2_1 - 0.21 11.4 14.0 0.14 12.0 1.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.7 MSTRG.11183.2_1 - 0.37 11.0 16.5 1.4 9.2 3.3 3.0 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3209 PF11483.6 MSTRG.11183.2_1 - 0.48 10.8 5.1 2.2 8.6 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3209) DUF4407 PF14362.4 MSTRG.11183.2_1 - 0.5 9.5 12.9 1 8.5 12.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DASH_Dam1 PF08653.8 MSTRG.11183.2_1 - 0.56 9.9 7.4 9.7 6.0 0.1 3.6 4 0 0 4 4 4 0 DASH complex subunit Dam1 Reo_sigmaC PF04582.10 MSTRG.11183.2_1 - 1.5 8.0 15.3 1.3 8.2 2.2 2.1 1 1 0 2 2 2 0 Reovirus sigma C capsid protein zf-RING_2 PF13639.4 MSTRG.11183.2_1 - 1.5 9.0 6.1 3.9 7.7 6.1 1.8 1 0 0 1 1 1 0 Ring finger domain bZIP_1 PF00170.19 MSTRG.11183.2_1 - 2.2 8.3 18.7 0.11 12.5 0.7 4.1 3 1 1 4 4 4 0 bZIP transcription factor APG17 PF04108.10 MSTRG.11183.2_1 - 4.8 6.0 17.4 0.55 9.2 10.3 2.1 1 1 1 2 2 2 0 Autophagy protein Apg17 LPP PF04728.11 MSTRG.11183.2_1 - 8.1 6.8 11.0 3 8.1 0.8 3.1 2 1 1 3 3 3 0 Lipoprotein leucine-zipper XhlA PF10779.7 MSTRG.11183.2_1 - 9.2 6.4 9.6 2.3 8.4 1.8 3.0 2 1 1 3 3 3 0 Haemolysin XhlA PNISR PF15996.3 MSTRG.2959.4_3 - 3 7.8 10.1 0.96 9.5 6.4 1.9 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR PTEN_C2 PF10409.7 MSTRG.20565.1_1 - 3.4e-30 104.4 4.7 9.1e-30 103.0 3.5 2.0 1 1 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.18 MSTRG.20565.1_1 - 2.3e-07 30.6 0.0 9.5e-07 28.6 0.0 1.9 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 MSTRG.20565.1_1 - 0.00044 19.8 0.0 0.00076 19.0 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.4 MSTRG.20565.1_1 - 0.0061 16.4 0.0 0.0099 15.7 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.4 MSTRG.20565.1_1 - 0.0099 15.9 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate PTEN_C2 PF10409.7 MSTRG.20565.1_3 - 1.6e-09 37.5 0.0 3.4e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein ACAS_N PF16177.3 MSTRG.28864.1_3 - 2.7e-14 52.7 0.0 4.8e-14 51.9 0.0 1.4 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus SAM_1 PF00536.28 MSTRG.20318.1_1 - 3.9e-14 52.7 0.1 1.8e-13 50.6 0.1 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) HD PF01966.20 MSTRG.20318.1_1 - 9.2e-13 48.4 0.0 2.9e-12 46.8 0.0 1.9 2 0 0 2 2 2 1 HD domain SAM_2 PF07647.15 MSTRG.20318.1_1 - 1e-10 41.4 0.0 2.2e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDEase_I PF00233.17 MSTRG.20318.1_1 - 0.038 13.6 0.0 0.072 12.7 0.0 1.4 1 0 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase Pox_MCEL PF03291.14 MSTRG.20318.1_1 - 0.088 11.8 0.0 0.19 10.7 0.0 1.4 1 0 0 1 1 1 0 mRNA capping enzyme BTB PF00651.29 MSTRG.29707.1_3 - 7e-25 87.3 0.3 1e-24 86.8 0.3 1.2 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.6 MSTRG.29707.1_3 - 0.0025 17.8 0.2 0.0039 17.2 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Gelsolin PF00626.20 MSTRG.2473.1_1 - 2.5e-23 81.6 0.0 2.8e-07 30.2 0.0 5.7 5 0 0 5 5 5 5 Gelsolin repeat DUF4695 PF15766.3 MSTRG.2473.1_1 - 1.4e-07 31.6 12.0 0.11 12.6 0.0 3.9 3 1 1 4 4 4 3 Domain of unknown function (DUF4695) Spectrin PF00435.19 MSTRG.19854.2_1 - 1.6e-212 690.5 129.9 5.7e-26 90.9 3.1 14.6 14 0 0 14 14 14 14 Spectrin repeat CH PF00307.29 MSTRG.19854.2_1 - 6.4e-51 171.0 1.5 6.8e-27 93.7 0.1 3.4 3 0 0 3 3 3 2 Calponin homology (CH) domain CAMSAP_CH PF11971.6 MSTRG.19854.2_1 - 3e-08 33.2 0.1 1.3e-06 28.0 0.0 2.8 2 0 0 2 2 2 1 CAMSAP CH domain Ribonuc_L-PSP PF01042.19 MSTRG.19854.2_1 - 0.081 12.8 0.0 0.27 11.1 0.0 1.9 1 0 0 1 1 1 0 Endoribonuclease L-PSP Osmo_CC PF08946.8 MSTRG.19854.2_1 - 0.11 12.6 13.6 51 4.1 0.0 6.8 6 0 0 6 6 6 0 Osmosensory transporter coiled coil DUF4828 PF16110.3 MSTRG.19854.2_1 - 0.12 12.7 0.1 5.3 7.5 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4828) NPV_P10 PF05531.10 MSTRG.19854.2_1 - 1.5 9.2 15.5 5 7.5 1.2 6.0 4 1 1 5 5 5 0 Nucleopolyhedrovirus P10 protein Spectrin PF00435.19 MSTRG.19854.2_3 - 3.5e-42 143.0 29.2 9.2e-18 64.5 2.2 4.4 4 0 0 4 4 4 4 Spectrin repeat PH_9 PF15410.4 MSTRG.19854.2_3 - 6.7e-11 42.5 0.0 1.5e-10 41.3 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 MSTRG.19854.2_3 - 3.6e-07 30.5 0.5 8.7e-07 29.3 0.0 1.9 2 0 0 2 2 2 1 PH domain MSA-2c PF12238.6 MSTRG.19854.2_3 - 3.3 7.5 5.2 3.2 7.6 2.3 2.3 2 0 0 2 2 2 0 Merozoite surface antigen 2c Hormone_recep PF00104.28 MSTRG.4453.1_1 - 1.8e-40 138.6 0.0 2.9e-40 137.9 0.0 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 MSTRG.4453.1_1 - 1e-29 102.6 18.3 1e-29 102.6 18.3 2.1 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) I-set PF07679.14 MSTRG.10276.1_1 - 0.029 14.3 0.0 2.7 8.0 0.0 2.6 3 0 0 3 3 3 0 Immunoglobulin I-set domain VPS9 PF02204.16 MSTRG.5730.1_3 - 8.8e-26 90.0 0.0 1.8e-25 89.0 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain zf-A20 PF01754.14 MSTRG.5730.1_3 - 1.1e-11 44.3 6.9 2.6e-11 43.1 6.9 1.7 1 0 0 1 1 1 1 A20-like zinc finger Snapin_Pallidin PF14712.4 MSTRG.5730.1_3 - 0.071 13.4 0.7 0.28 11.5 0.1 2.1 2 0 0 2 2 2 0 Snapin/Pallidin EF-hand_1 PF00036.30 MSTRG.17910.1_2 - 1.2e-21 74.4 7.2 0.00035 19.8 0.2 6.4 6 0 0 6 6 6 5 EF hand EF-hand_7 PF13499.4 MSTRG.17910.1_2 - 4.8e-17 62.1 19.6 3.4e-07 30.5 1.5 4.3 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.17910.1_2 - 6.6e-13 47.4 10.9 0.036 13.9 0.0 6.2 6 0 0 6 6 6 4 EF-hand domain EF-hand_5 PF13202.4 MSTRG.17910.1_2 - 8.8e-12 43.8 12.0 0.0004 19.6 0.3 5.2 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.4 MSTRG.17910.1_2 - 1.3e-07 31.2 8.0 0.076 12.7 0.2 4.9 4 1 1 5 5 5 4 EF-hand domain pair SPARC_Ca_bdg PF10591.7 MSTRG.17910.1_2 - 0.00023 21.3 12.0 0.16 12.2 0.2 3.3 3 0 0 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region V-set PF07686.15 MSTRG.27842.2_1 - 3.9e-09 36.5 0.0 6.4e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 MSTRG.27842.2_1 - 0.0062 17.0 0.0 0.012 16.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain G6B PF15096.4 MSTRG.27842.2_1 - 0.037 13.6 0.0 0.062 12.9 0.0 1.3 1 0 0 1 1 1 0 G6B family Ras PF00071.20 MSTRG.3825.1_1 - 4.7e-58 195.2 0.3 7.2e-58 194.6 0.3 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.3825.1_1 - 1.8e-35 121.6 0.1 3.5e-35 120.7 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.3825.1_1 - 8e-15 54.6 0.1 1.1e-14 54.1 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 MSTRG.3825.1_1 - 3.4e-05 23.4 0.1 0.00013 21.5 0.1 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.8 MSTRG.3825.1_1 - 4.8e-05 22.7 0.1 7.9e-05 22.0 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 MSTRG.3825.1_1 - 0.00029 20.8 0.0 0.00053 19.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 MSTRG.3825.1_1 - 0.00098 18.9 0.2 0.4 10.4 0.0 2.5 3 0 0 3 3 3 2 Protein of unknown function, DUF258 Gtr1_RagA PF04670.10 MSTRG.3825.1_1 - 0.0027 17.0 0.2 0.0041 16.4 0.2 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.16 MSTRG.3825.1_1 - 0.0044 16.4 0.2 0.043 13.2 0.2 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B Ras PF00071.20 MSTRG.22050.1_2 - 3.2e-57 192.5 0.0 4.5e-57 192.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.22050.1_2 - 1.3e-20 73.6 0.0 2.3e-20 72.9 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.22050.1_2 - 2.1e-08 33.7 0.0 3e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 MSTRG.22050.1_2 - 1.1e-05 24.9 0.1 3e-05 23.5 0.1 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 MSTRG.22050.1_2 - 0.00015 21.6 0.0 0.15 11.8 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 MSTRG.22050.1_2 - 0.00036 20.5 0.0 0.00062 19.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase ArgK PF03308.14 MSTRG.22050.1_2 - 0.038 12.8 0.2 0.18 10.7 0.0 1.8 2 0 0 2 2 2 0 ArgK protein FeoB_N PF02421.16 MSTRG.22050.1_2 - 0.089 12.2 0.0 0.3 10.5 0.0 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B STIL_N PF15253.4 MSTRG.24355.1_1 - 3.3e-143 477.4 0.0 4.5e-143 476.9 0.0 1.2 1 0 0 1 1 1 1 SCL-interrupting locus protein N-terminus Carn_acyltransf PF00755.18 MSTRG.20949.1_1 - 2.4e-199 663.6 0.0 2.8e-199 663.4 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase PARP PF00644.18 MSTRG.25098.1_1 - 1e-33 116.6 0.0 1.5e-33 116.1 0.0 1.1 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Not3 PF04065.13 MSTRG.6869.1_3 - 6.1e-97 323.5 27.0 9.6e-97 322.8 27.0 1.3 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.16 MSTRG.6869.1_3 - 7.8e-38 129.4 11.0 7.8e-38 129.4 11.0 2.0 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family ZnuA PF01297.15 MSTRG.6869.1_3 - 0.12 11.6 1.7 0.19 10.9 1.7 1.3 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic Syntaxin_2 PF14523.4 MSTRG.6869.1_3 - 1.5 9.1 12.2 0.52 10.6 1.2 3.1 3 0 0 3 3 3 0 Syntaxin-like protein Pkinase PF00069.23 MSTRG.18364.1_3 - 9.9e-145 480.6 0.0 2.5e-72 243.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.18364.1_3 - 5.7e-77 258.4 0.0 2.2e-40 138.5 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.18364.1_3 - 1.2e-13 50.9 0.0 2.6e-07 30.1 0.0 2.7 3 0 0 3 3 3 2 Kinase-like Kdo PF06293.12 MSTRG.18364.1_3 - 6.8e-13 48.3 0.1 7e-08 31.9 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_C PF00433.22 MSTRG.18364.1_3 - 1.3e-06 28.8 1.6 3.5e-06 27.5 1.6 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain APH PF01636.21 MSTRG.18364.1_3 - 0.00014 21.7 0.0 0.35 10.6 0.0 2.3 2 0 0 2 2 2 2 Phosphotransferase enzyme family FTA2 PF13095.4 MSTRG.18364.1_3 - 0.00046 19.8 0.1 7.4 6.0 0.0 3.3 3 0 0 3 3 3 3 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.7 MSTRG.18364.1_3 - 0.0089 15.4 0.0 0.21 11.0 0.0 2.3 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL RIO1 PF01163.20 MSTRG.18364.1_3 - 0.13 11.7 0.1 0.42 10.1 0.0 1.8 2 0 0 2 2 2 0 RIO1 family Cyclin_N PF00134.21 MSTRG.18741.1_1 - 4.2e-25 87.9 0.0 7.4e-25 87.0 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Dickkopf_N PF04706.10 MSTRG.13819.1_2 - 0.69 10.3 9.3 1.3 9.4 3.6 2.3 2 0 0 2 2 2 0 Dickkopf N-terminal cysteine-rich region HbrB PF08539.9 MSTRG.18437.1_3 - 3.8e-13 49.7 1.2 9.6e-12 45.1 0.2 2.2 1 1 1 2 2 2 2 HbrB-like CENP-B_dimeris PF09026.8 MSTRG.1297.2_2 - 0.62 10.4 3.4 15 5.9 0.2 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF4490 PF14892.4 MSTRG.18408.2_2 - 2.1e-18 66.1 0.7 3.4e-18 65.5 0.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4490) Integrin_b_cyt PF08725.9 MSTRG.18408.2_2 - 0.032 13.8 0.0 0.076 12.6 0.0 1.7 1 0 0 1 1 1 0 Integrin beta cytoplasmic domain EURL PF06937.9 MSTRG.22766.2_2 - 2.9e-119 397.6 3.3 4.1e-119 397.1 3.3 1.2 1 0 0 1 1 1 1 EURL protein Peptidase_S49_N PF08496.8 MSTRG.17954.2_1 - 0.76 9.7 2.3 1.5 8.8 2.3 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal CASP_C PF08172.10 MSTRG.17954.2_3 - 9.6e-59 198.6 4.0 4e-58 196.6 4.0 2.0 1 1 0 1 1 1 1 CASP C terminal DUF2205 PF10224.7 MSTRG.17954.2_3 - 4.3e-05 23.3 0.4 7.9e-05 22.4 0.4 1.3 1 0 0 1 1 1 1 Predicted coiled-coil protein (DUF2205) DUF4407 PF14362.4 MSTRG.17954.2_3 - 0.013 14.8 0.2 0.013 14.8 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) CCDC-167 PF15188.4 MSTRG.17954.2_3 - 0.019 15.2 0.6 0.081 13.1 0.6 2.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 GIT_CC PF16559.3 MSTRG.17954.2_3 - 0.098 12.6 2.1 0.18 11.8 2.1 1.4 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Calcyon PF06387.9 MSTRG.17954.2_3 - 0.26 11.1 0.0 0.26 11.1 0.0 1.8 2 0 0 2 2 2 0 D1 dopamine receptor-interacting protein (calcyon) KLRAQ PF10205.7 MSTRG.17954.2_3 - 0.34 11.0 6.8 0.079 13.1 0.4 2.2 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein DUF4618 PF15397.4 MSTRG.17954.2_3 - 0.45 9.8 5.1 0.075 12.3 0.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) PDCD7 PF16021.3 MSTRG.17954.2_3 - 0.73 8.8 7.2 0.27 10.2 0.2 2.1 2 0 0 2 2 2 0 Programmed cell death protein 7 CEP63 PF17045.3 MSTRG.17954.2_3 - 1.7 8.3 9.0 0.89 9.3 0.4 2.2 2 0 0 2 2 2 0 Centrosomal protein of 63 kDa DUF4482 PF14818.4 MSTRG.17954.2_3 - 1.8 9.3 9.1 0.078 13.7 1.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) TMF_TATA_bd PF12325.6 MSTRG.17954.2_3 - 2.7 8.1 8.6 0.056 13.5 0.5 2.2 3 0 0 3 3 2 0 TATA element modulatory factor 1 TATA binding OmpH PF03938.12 MSTRG.17954.2_3 - 9.8 6.0 9.1 0.86 9.5 0.6 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Troponin PF00992.18 MSTRG.2676.2_1 - 4.1e-27 95.0 45.6 3.9e-25 88.6 36.5 2.1 1 1 1 2 2 2 2 Troponin REJ PF02010.13 MSTRG.18966.1_1 - 7.7e-56 189.6 0.6 8.6e-56 189.5 0.6 1.0 1 0 0 1 1 1 1 REJ domain SHIPPO-rpt PF07004.10 MSTRG.10514.1_1 - 0.069 14.0 1.0 0.19 12.6 0.6 1.9 2 0 0 2 2 2 0 Sperm-tail PG-rich repeat CENP-B_dimeris PF09026.8 MSTRG.10514.1_1 - 0.12 12.6 3.2 0.21 11.9 3.2 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RBD-FIP PF09457.8 MSTRG.19932.2_3 - 5.4e-09 35.7 1.5 9.9e-09 34.8 1.5 1.5 1 0 0 1 1 1 1 FIP domain WSC PF01822.17 MSTRG.3055.3_3 - 0.00045 20.2 1.4 0.001 19.1 0.3 2.1 2 0 0 2 2 2 1 WSC domain RabGAP-TBC PF00566.16 MSTRG.17634.1_2 - 7.4e-34 117.1 8.2 1.3e-32 113.1 4.2 2.4 2 0 0 2 2 2 2 Rab-GTPase-TBC domain RUN PF02759.17 MSTRG.17634.1_3 - 9.3e-35 119.4 0.4 2.2e-34 118.2 0.4 1.7 1 0 0 1 1 1 1 RUN domain Nnf1 PF03980.12 MSTRG.17634.1_3 - 0.026 14.8 0.2 0.026 14.8 0.2 2.5 3 0 0 3 3 3 0 Nnf1 TPR_14 PF13428.4 MSTRG.22659.1_3 - 3.9e-13 48.9 4.5 0.12 13.1 0.8 6.6 4 1 2 6 6 6 4 Tetratricopeptide repeat NRDE-2 PF08424.8 MSTRG.22659.1_3 - 3.2e-05 23.1 2.4 0.0012 17.9 0.1 2.5 2 1 0 2 2 2 2 NRDE-2, necessary for RNA interference TPR_10 PF13374.4 MSTRG.22659.1_3 - 0.00015 21.4 1.2 0.0042 16.8 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.22659.1_3 - 0.0098 16.3 0.1 0.39 11.1 0.2 2.8 1 1 0 2 2 2 1 Tetratricopeptide repeat Suf PF05843.12 MSTRG.22659.1_3 - 0.077 12.8 0.0 0.077 12.8 0.0 3.7 3 1 1 4 4 4 0 Suppressor of forked protein (Suf) TPR_12 PF13424.4 MSTRG.22659.1_3 - 0.14 12.3 0.9 1.1 9.5 0.1 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat DDE_Tnp_4 PF13359.4 MSTRG.12498.2_2 - 1.3e-33 115.7 0.0 2.5e-33 114.8 0.0 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease Plant_tran PF04827.12 MSTRG.12498.2_2 - 6.5e-06 25.7 0.0 0.00025 20.6 0.0 2.1 1 1 0 1 1 1 1 Plant transposon protein Cwf_Cwc_15 PF04889.10 MSTRG.3847.1_3 - 1.5e-77 260.5 23.9 1.8e-77 260.3 23.9 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein NRN1 PF15056.4 MSTRG.3847.1_3 - 0.071 13.1 0.3 0.14 12.1 0.3 1.4 1 0 0 1 1 1 0 Neuritin protein family SRP-alpha_N PF04086.11 MSTRG.3847.1_3 - 0.08 12.7 18.1 0.1 12.3 18.1 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Neur_chan_memb PF02932.14 MSTRG.3847.1_3 - 0.3 11.0 8.3 0.42 10.5 8.3 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Nop PF01798.16 MSTRG.13728.1_1 - 5e-86 287.8 0.0 8.4e-86 287.0 0.0 1.4 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.11 MSTRG.13728.1_1 - 8.5e-20 70.7 0.5 2.6e-19 69.2 0.5 1.9 1 0 0 1 1 1 1 NOP5NT (NUC127) domain Peptidase_C48 PF02902.17 MSTRG.23045.2_2 - 3.5e-41 141.3 1.0 6e-41 140.5 1.0 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Peptidase_C57 PF03290.11 MSTRG.23045.2_2 - 0.0066 15.1 0.3 1.6 7.3 0.0 2.1 2 0 0 2 2 2 2 Vaccinia virus I7 processing peptidase NAD_Gly3P_dh_N PF01210.21 MSTRG.2722.1_3 - 4e-52 176.2 1.4 2.5e-51 173.6 0.3 2.2 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.12 MSTRG.2722.1_3 - 1.3e-48 164.8 0.1 3e-48 163.6 0.1 1.6 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.15 MSTRG.2722.1_3 - 0.014 15.8 1.2 0.27 11.7 0.3 2.7 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent RRM_1 PF00076.20 MSTRG.8996.3_1 - 5.3e-39 131.8 0.0 8.1e-21 73.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 MSTRG.8996.3_1 - 3.2e-07 29.9 0.0 3.5e-05 23.3 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.10 MSTRG.8996.3_1 - 0.063 13.4 0.0 0.35 11.0 0.0 2.0 2 0 0 2 2 2 0 BRCA1-associated protein 2 RNA_bind PF08675.9 MSTRG.8996.3_1 - 0.094 12.6 0.0 1.4 8.8 0.0 2.5 2 2 0 2 2 2 0 RNA binding domain RRM_3 PF08777.9 MSTRG.8996.3_1 - 0.15 12.0 0.0 0.39 10.6 0.0 1.7 1 0 0 1 1 1 0 RNA binding motif RRM_1 PF00076.20 MSTRG.8996.3_3 - 3e-06 26.8 0.0 5.7e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHD_4 PF16866.3 MSTRG.30.1_3 - 0.0001 22.2 3.1 0.0001 22.2 3.1 2.1 2 0 0 2 2 2 1 PHD-finger Rubredoxin PF00301.18 MSTRG.30.1_3 - 0.048 13.5 0.5 0.11 12.4 0.5 1.5 1 0 0 1 1 1 0 Rubredoxin PID PF00640.21 MSTRG.8848.6_3 - 6.1e-33 113.7 0.3 1.1e-32 112.9 0.3 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) NumbF PF06311.10 MSTRG.8848.6_3 - 8e-27 93.5 0.9 2.5e-26 92.0 0.2 2.2 2 0 0 2 2 2 1 NUMB domain PID_2 PF14719.4 MSTRG.8848.6_3 - 8.2e-05 22.4 0.2 0.00013 21.7 0.2 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 MSTRG.8848.6_3 - 8.4e-05 22.6 0.0 0.00015 21.7 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PAS_11 PF14598.4 MSTRG.27945.1_1 - 1.6e-20 73.1 0.0 1.6e-20 73.1 0.0 3.7 4 1 0 4 4 4 1 PAS domain PAS_3 PF08447.10 MSTRG.27945.1_1 - 7.6e-17 61.2 0.1 4.3e-15 55.6 0.1 2.7 2 0 0 2 2 2 1 PAS fold HLH PF00010.24 MSTRG.27945.1_1 - 1.5e-09 37.5 0.5 3e-09 36.6 0.5 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS PF00989.23 MSTRG.27945.1_1 - 3e-06 27.1 0.0 3e-06 27.1 0.0 4.8 4 1 1 5 5 5 1 PAS fold PAS_9 PF13426.5 MSTRG.27945.1_1 - 0.0032 17.6 0.0 0.019 15.1 0.0 2.3 2 0 0 2 2 2 1 PAS domain ABC2_membrane_2 PF12679.5 MSTRG.27945.1_1 - 8.9 5.4 9.3 11 5.1 4.1 2.3 2 0 0 2 2 2 0 ABC-2 family transporter protein Ank_2 PF12796.5 MSTRG.19400.2_1 - 7.8e-160 519.8 75.0 1.2e-17 64.2 0.4 13.9 1 1 16 17 17 17 17 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.19400.2_1 - 1.9e-137 445.9 51.8 1.5e-14 54.0 0.3 19.7 5 5 15 22 22 22 22 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.19400.2_1 - 4e-135 434.8 73.9 3.6e-07 30.2 0.1 27.6 26 1 1 27 27 27 26 Ankyrin repeat Ank_5 PF13857.4 MSTRG.19400.2_1 - 2.7e-111 361.5 61.6 3.6e-09 36.6 0.0 20.8 7 5 15 22 22 22 22 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.19400.2_1 - 3.3e-102 321.8 52.3 2.5e-06 27.3 0.1 27.8 28 0 0 28 28 28 25 Ankyrin repeat Methyltransf_23 PF13489.4 MSTRG.3556.1_1 - 4.4e-14 52.6 0.0 6.6e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 MSTRG.3556.1_1 - 9.5e-13 48.6 0.0 1.8e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 MSTRG.3556.1_1 - 2.8e-11 43.9 0.0 5.2e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 MSTRG.3556.1_1 - 1.1e-08 35.4 0.1 1.9e-08 34.7 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 MSTRG.3556.1_1 - 7.2e-07 29.0 0.0 1.2e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.12 MSTRG.3556.1_1 - 0.13 11.7 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Cyclin_N PF00134.21 MSTRG.18740.1_3 - 2.7e-16 59.4 0.1 4.3e-16 58.7 0.1 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain HDAC4_Gln PF12203.6 MSTRG.9115.2_1 - 8.2e-26 89.9 53.0 8.2e-26 89.9 53.0 3.6 4 1 0 4 4 4 1 Glutamine rich N terminal domain of histone deacetylase 4 Glyco_hydro_63N PF16923.3 MSTRG.9115.2_1 - 0.02 14.9 6.0 0.043 13.8 6.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 63 N-terminal domain Ras PF00071.20 MSTRG.956.2_1 - 1.7e-15 56.9 0.1 2.6e-15 56.3 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.956.2_1 - 0.034 14.2 0.0 0.065 13.3 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase p450 PF00067.20 MSTRG.15072.2_1 - 3.1e-96 322.8 0.1 3.9e-96 322.5 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 FliH PF02108.14 MSTRG.15072.2_1 - 0.061 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Flagellar assembly protein FliH DUF5090 PF17009.3 MSTRG.15072.2_1 - 0.45 10.3 8.1 0.92 9.3 8.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5090) G-alpha PF00503.18 MSTRG.19660.2_3 - 1e-115 386.6 3.3 1.4e-115 386.2 3.3 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 MSTRG.19660.2_3 - 9.1e-15 54.4 1.1 1.5e-11 43.9 0.3 2.6 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 MSTRG.19660.2_3 - 0.00034 19.9 2.5 0.0051 16.1 0.1 2.3 2 1 0 2 2 2 1 Gtr1/RagA G protein conserved region AAA_29 PF13555.4 MSTRG.19660.2_3 - 0.037 13.6 0.0 0.93 9.1 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain Roc PF08477.11 MSTRG.19660.2_3 - 0.076 13.1 0.1 7 6.8 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF258 PF03193.14 MSTRG.19660.2_3 - 0.095 12.5 0.0 0.46 10.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 MSTRG.19660.2_3 - 0.12 11.8 0.0 0.76 9.1 0.0 2.0 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain IMS PF00817.18 MSTRG.16827.1_1 - 3.2e-41 140.7 0.0 5.9e-41 139.8 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.6 MSTRG.16827.1_1 - 5.1e-18 65.8 0.0 9.4e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.6 MSTRG.16827.1_1 - 0.00024 21.1 0.0 0.00052 20.1 0.0 1.6 1 0 0 1 1 1 1 IMS family HHH motif Cdd1 PF11731.6 MSTRG.16827.1_1 - 0.0072 16.4 0.0 0.016 15.3 0.0 1.5 1 0 0 1 1 1 1 Pathogenicity locus DNA_pol_lambd_f PF10391.7 MSTRG.16827.1_1 - 0.011 15.5 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda Malate_DH PF12434.6 MSTRG.16827.1_3 - 0.001 18.9 0.5 0.0028 17.5 0.5 1.8 1 0 0 1 1 1 1 Malate dehydrogenase enzyme Herpes_PAP PF03325.11 MSTRG.1802.1_1 - 0.88 8.5 3.2 1.3 7.9 3.2 1.1 1 0 0 1 1 1 0 Herpesvirus polymerase accessory protein Fumble PF03630.12 MSTRG.18331.1_2 - 5.4e-120 400.4 0.0 7e-120 400.0 0.0 1.1 1 0 0 1 1 1 1 Fumble fn3 PF00041.19 MSTRG.24855.2_2 - 1.8e-19 69.7 1.0 3.8e-12 46.3 0.0 3.3 3 0 0 3 3 3 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 MSTRG.24855.2_2 - 0.0013 19.1 0.1 0.3 11.5 0.0 2.4 2 0 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.3 MSTRG.24855.2_2 - 0.16 12.0 0.0 1.1e+02 2.9 0.0 3.1 3 0 0 3 3 3 0 Fibronectin type III domain fn3 PF00041.19 MSTRG.24855.2_3 - 2.2e-72 239.3 10.2 1.1e-14 54.4 0.2 5.5 5 0 0 5 5 5 5 Fibronectin type III domain I-set PF07679.14 MSTRG.24855.2_3 - 6.8e-46 154.1 0.0 3.5e-16 58.9 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.24855.2_3 - 4.7e-43 145.6 0.2 1.9e-13 50.7 0.0 4.8 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.24855.2_3 - 3.9e-24 84.6 0.0 2e-08 34.4 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 MSTRG.24855.2_3 - 6.6e-17 61.3 0.0 0.00013 21.9 0.0 3.8 4 0 0 4 4 3 3 Immunoglobulin domain Pur_ac_phosph_N PF16656.3 MSTRG.24855.2_3 - 9.4e-14 51.6 4.2 0.018 15.4 0.2 6.1 5 0 0 5 5 5 3 Purple acid Phosphatase, N-terminal domain V-set PF07686.15 MSTRG.24855.2_3 - 5.6e-11 42.4 0.6 0.21 11.7 0.0 6.5 5 3 0 6 6 6 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 MSTRG.24855.2_3 - 4e-09 36.3 0.1 0.076 13.0 0.0 3.8 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain Interfer-bind PF09294.8 MSTRG.24855.2_3 - 5.8e-09 36.1 0.0 0.092 12.9 0.0 5.2 5 0 0 5 5 5 2 Interferon-alpha/beta receptor, fibronectin type III fn3_2 PF16893.3 MSTRG.24855.2_3 - 1.3e-07 31.5 0.0 0.0074 16.3 0.0 3.9 3 0 0 3 3 3 2 Fibronectin type III domain Ig_5 PF16681.3 MSTRG.24855.2_3 - 3e-07 30.7 0.0 0.063 13.6 0.0 3.4 3 0 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C1-set PF07654.13 MSTRG.24855.2_3 - 0.0014 18.9 0.0 5.2 7.5 0.0 3.8 3 0 0 3 3 3 1 Immunoglobulin C1-set domain fn3_4 PF16794.3 MSTRG.24855.2_3 - 0.044 13.6 0.1 48 3.8 0.0 4.2 4 1 0 4 4 4 0 Fibronectin-III type domain ICAM_N PF03921.12 MSTRG.24855.2_3 - 0.085 12.4 0.0 0.25 10.9 0.0 1.8 1 0 0 1 1 1 0 Intercellular adhesion molecule (ICAM), N-terminal domain zf-4CXXC_R1 PF10497.7 MSTRG.5088.1_1 - 6.1e-35 119.3 10.9 1.1e-34 118.4 10.9 1.5 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 VWD PF00094.23 MSTRG.11951.9_3 - 7.7e-162 533.0 25.7 1.8e-38 132.1 0.0 5.3 5 0 0 5 5 5 5 von Willebrand factor type D domain C8 PF08742.9 MSTRG.11951.9_3 - 1.6e-78 258.9 34.5 1e-23 83.4 1.1 8.4 8 0 0 8 8 8 4 C8 domain TILa PF12714.5 MSTRG.11951.9_3 - 2.1e-51 171.6 97.3 6.1e-15 54.8 11.8 11.9 11 1 0 11 11 11 6 TILa domain TIL PF01826.15 MSTRG.11951.9_3 - 2e-45 152.7 109.1 9.6e-13 48.0 15.3 14.6 15 0 0 15 15 15 5 Trypsin Inhibitor like cysteine rich domain VWC PF00093.16 MSTRG.11951.9_3 - 0.00019 21.5 9.4 0.00019 21.5 9.4 13.8 11 4 0 12 12 12 6 von Willebrand factor type C domain Myosin_N PF02736.17 MSTRG.11951.9_3 - 0.02 14.6 1.5 0.2 11.4 0.5 2.5 2 0 0 2 2 2 0 Myosin N-terminal SH3-like domain Uso1_p115_head PF04869.12 MSTRG.27616.4_3 - 7.4e-65 219.0 2.4 8e-65 218.9 0.0 2.3 3 0 0 3 3 3 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.11 MSTRG.27616.4_3 - 6.4e-11 42.6 32.5 6.4e-11 42.6 32.5 4.5 2 1 2 4 4 4 1 Uso1 / p115 like vesicle tethering protein, C terminal region TMF_TATA_bd PF12325.6 MSTRG.27616.4_3 - 0.0038 17.3 11.7 0.0038 17.3 11.7 4.5 3 1 1 4 4 4 1 TATA element modulatory factor 1 TATA binding Atx10homo_assoc PF09759.7 MSTRG.27616.4_3 - 0.023 14.6 5.2 0.36 10.8 0.2 4.4 3 1 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain TMF_DNA_bd PF12329.6 MSTRG.27616.4_3 - 0.17 11.8 0.1 0.17 11.8 0.1 7.4 4 3 3 7 7 7 0 TATA element modulatory factor 1 DNA binding Spc7 PF08317.9 MSTRG.27616.4_3 - 0.4 9.4 49.2 0.065 12.0 15.1 3.6 2 1 1 3 3 3 0 Spc7 kinetochore protein ATG16 PF08614.9 MSTRG.27616.4_3 - 5.4 7.0 60.6 16 5.5 24.6 3.7 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) DUF4407 PF14362.4 MSTRG.27616.4_3 - 9.4 5.4 42.8 0.13 11.5 4.0 3.4 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) FAM217 PF15344.4 MSTRG.6351.1_1 - 6.2e-58 196.4 0.6 6.2e-58 196.4 0.6 1.8 2 0 0 2 2 2 1 FAM217 family DUF4125 PF13526.4 MSTRG.6351.1_1 - 9e-05 22.0 0.0 0.00014 21.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4125) Striatin PF08232.10 MSTRG.1333.1_2 - 6.6e-48 163.1 5.6 6.6e-48 163.1 5.6 2.5 2 1 0 2 2 2 1 Striatin family WD40 PF00400.30 MSTRG.1333.1_2 - 9.9e-06 26.1 0.0 2.6e-05 24.8 0.0 1.8 1 0 0 1 1 1 1 WD domain, G-beta repeat DUF4482 PF14818.4 MSTRG.1333.1_2 - 0.18 12.6 4.3 0.099 13.4 1.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) V-set PF07686.15 MSTRG.14388.1_3 - 2.1e-13 50.3 0.0 3.2e-13 49.7 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 MSTRG.14388.1_3 - 1.9e-05 25.0 0.0 3.7e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 MSTRG.14388.1_3 - 4.2e-05 23.4 0.0 8.5e-05 22.4 0.0 1.4 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 MSTRG.14388.1_3 - 0.00013 22.0 0.0 0.00028 20.8 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.14388.1_3 - 0.0025 18.0 0.0 0.015 15.5 0.0 2.2 1 1 1 2 2 2 1 Immunoglobulin domain PDEase_I PF00233.17 MSTRG.10703.3_2 - 3.9e-93 311.4 3.6 7.2e-93 310.6 3.6 1.4 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase PV_NSP1 PF12433.6 MSTRG.10703.3_2 - 0.079 13.2 0.2 8.6 6.7 0.1 2.6 2 0 0 2 2 2 0 Parvovirus non-structural protein 1 RhoGAP PF00620.25 MSTRG.15637.1_2 - 4e-40 137.0 5.1 8.5e-40 135.9 0.0 3.0 3 0 0 3 3 3 1 RhoGAP domain WD40 PF00400.30 MSTRG.19276.1_1 - 0.0017 19.0 0.2 0.036 14.8 0.0 2.5 3 0 0 3 3 3 1 WD domain, G-beta repeat WD40 PF00400.30 MSTRG.19276.1_2 - 0.0017 19.0 7.9 0.51 11.2 0.2 3.9 4 0 0 4 4 4 2 WD domain, G-beta repeat CFC PF09443.8 MSTRG.20952.1_2 - 2.4e-16 59.1 14.9 3.1e-16 58.8 10.3 2.8 2 0 0 2 2 2 1 Cripto_Frl-1_Cryptic (CFC) Arrestin_C PF02752.20 MSTRG.22417.2_3 - 1.3e-06 28.7 0.1 2e-06 28.0 0.1 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain MBD PF01429.17 MSTRG.2210.1_1 - 2.5e-12 46.2 1.2 6.1e-12 45.0 0.0 2.2 3 0 0 3 3 3 1 Methyl-CpG binding domain NicO PF03824.14 MSTRG.2210.1_1 - 6 6.0 11.7 15 4.7 11.7 1.7 1 0 0 1 1 1 0 High-affinity nickel-transport protein AKAP7_RIRII_bdg PF10470.7 MSTRG.9634.3_2 - 5.3e-14 51.9 0.5 8.4e-14 51.2 0.5 1.3 1 0 0 1 1 1 1 PKA-RI-RII subunit binding domain of A-kinase anchor protein Anoctamin PF04547.10 MSTRG.5843.2_2 - 1.2e-162 541.6 24.0 1.9e-162 540.9 24.0 1.3 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.3 MSTRG.5843.2_2 - 7e-72 241.7 0.3 1e-71 241.1 0.3 1.3 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin LRR_6 PF13516.4 MSTRG.9032.1_3 - 0.00057 19.6 0.0 3.9 7.6 0.0 3.6 4 0 0 4 4 4 2 Leucine Rich repeat Hairy_orange PF07527.11 MSTRG.3219.2_2 - 2e-18 66.2 0.2 3.3e-18 65.5 0.2 1.4 1 0 0 1 1 1 1 Hairy Orange HLH PF00010.24 MSTRG.3219.2_2 - 5.4e-14 51.8 5.2 7.3e-14 51.3 4.4 1.7 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain HSP70 PF00012.18 MSTRG.20653.3_3 - 2.5e-108 362.7 0.0 3.1e-108 362.4 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 MSTRG.20653.3_3 - 2.1e-10 39.8 0.0 4.1e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 MreB/Mbl protein FGGY_C PF02782.14 MSTRG.20653.3_3 - 0.023 14.3 0.0 0.058 13.0 0.0 1.7 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain HTH_9 PF08221.9 MSTRG.20653.3_3 - 0.06 13.3 0.1 0.16 11.9 0.1 1.8 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain rve PF00665.24 MSTRG.28091.1_3 - 0.0009 19.3 0.0 0.0016 18.5 0.0 1.5 1 1 0 1 1 1 1 Integrase core domain Vinculin PF01044.17 MSTRG.4924.1_3 - 0 1560.2 37.7 5.3e-282 938.4 15.2 2.0 1 1 1 2 2 2 2 Vinculin family Latarcin PF10279.7 MSTRG.4924.1_3 - 0.0045 17.2 0.0 0.57 10.5 0.0 3.9 4 2 0 4 4 4 1 Latarcin precursor Mob_Pre PF01076.17 MSTRG.4924.1_3 - 0.025 14.3 0.2 0.086 12.5 0.2 1.9 1 0 0 1 1 1 0 Plasmid recombination enzyme TipAS PF07739.11 MSTRG.4924.1_3 - 0.13 12.7 0.1 0.13 12.7 0.1 5.1 6 1 0 7 7 7 0 TipAS antibiotic-recognition domain Hemerythrin PF01814.21 MSTRG.4924.1_3 - 1.4 9.4 4.9 72 3.9 0.1 4.3 3 1 0 3 3 3 0 Hemerythrin HHE cation binding domain Jacalin PF01419.15 MSTRG.9604.3_3 - 1.2e-05 25.1 0.1 1.9e-05 24.5 0.1 1.3 1 0 0 1 1 1 1 Jacalin-like lectin domain zf-CCHC_2 PF13696.4 MSTRG.9604.3_3 - 0.92 9.2 4.6 0.68 9.7 1.0 2.5 2 0 0 2 2 2 0 Zinc knuckle 4F5 PF04419.12 MSTRG.5521.2_3 - 2.3e-07 31.4 12.3 2.3e-07 31.4 12.3 2.3 2 0 0 2 2 2 1 4F5 protein family DUF2362 PF10154.7 MSTRG.18394.1_3 - 2.9e-207 689.4 10.7 3.5e-207 689.2 10.7 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2362) BRCA-2_helical PF09169.8 MSTRG.25371.2_3 - 5.3e-88 293.5 0.0 9.4e-88 292.6 0.0 1.4 1 0 0 1 1 1 1 BRCA2, helical BRCA-2_OB3 PF09104.8 MSTRG.25371.2_3 - 1.3e-46 157.5 0.0 2.2e-46 156.8 0.0 1.4 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 BRCA-2_OB1 PF09103.8 MSTRG.25371.2_3 - 6.3e-37 126.1 0.0 1.1e-36 125.3 0.0 1.4 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 Tower PF09121.8 MSTRG.25371.2_3 - 1.3e-16 60.4 1.8 2.8e-16 59.3 1.8 1.6 1 0 0 1 1 1 1 Tower Tantalus PF15386.4 MSTRG.19585.2_3 - 2.5e-24 85.0 0.5 4.8e-24 84.1 0.5 1.5 1 0 0 1 1 1 1 Drosophila Tantalus-like Kunitz_BPTI PF00014.21 MSTRG.19391.3_3 - 9.8e-57 188.9 38.8 1.7e-19 69.7 3.9 3.3 3 0 0 3 3 3 3 Kunitz/Bovine pancreatic trypsin inhibitor domain WW PF00397.24 MSTRG.19391.3_3 - 1.2 9.1 9.0 6.4 6.7 0.8 2.6 2 0 0 2 2 2 0 WW domain Peptidase_M14 PF00246.22 MSTRG.4766.1_2 - 3.1e-14 53.3 0.0 5.5e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase DUF4819 PF16090.3 MSTRG.23313.1_2 - 1.1e-18 66.8 0.0 3.8e-18 65.1 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4819) HMG_box PF00505.17 MSTRG.23313.1_2 - 2.9e-17 62.7 1.5 9.1e-17 61.1 1.5 1.9 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 MSTRG.23313.1_2 - 5e-07 30.1 0.4 5e-07 30.1 0.4 2.0 2 0 0 2 2 2 1 HMG-box domain K_channel_TID PF07941.9 MSTRG.4660.4_1 - 0.15 12.4 5.2 0.44 10.9 5.2 1.7 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain SRF-TF PF00319.16 MSTRG.4660.4_2 - 1.8e-23 81.6 0.4 3.8e-23 80.6 0.4 1.6 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.6 MSTRG.4660.4_2 - 1.4e-22 79.3 0.8 3.7e-22 77.9 0.8 1.8 1 0 0 1 1 1 1 Holliday junction regulator protein family C-terminal repeat Pkinase_Tyr PF07714.15 MSTRG.511.1_1 - 8.4e-92 307.0 0.0 1.1e-91 306.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.511.1_1 - 5.6e-44 150.3 0.0 8.4e-44 149.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 MSTRG.511.1_1 - 7.5e-27 93.1 0.5 1.5e-26 92.2 0.5 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 MSTRG.511.1_1 - 1.5e-17 62.8 0.0 5.9e-17 60.9 0.0 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 MSTRG.511.1_1 - 4.2e-12 45.6 0.0 9.7e-12 44.4 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.511.1_1 - 3e-08 33.1 0.0 6.9e-08 31.9 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain hSH3 PF14603.4 MSTRG.511.1_1 - 0.094 13.1 0.0 0.19 12.2 0.0 1.4 1 0 0 1 1 1 0 Helically-extended SH3 domain EF-hand_6 PF13405.4 MSTRG.22891.3_3 - 0.0012 18.5 0.1 0.0022 17.7 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain UPF0154 PF03672.11 MSTRG.22891.3_3 - 0.078 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) DUF3235 PF11574.6 MSTRG.22891.3_3 - 0.43 11.3 4.8 0.92 10.3 4.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3235) DUF3597 PF12200.6 MSTRG.22891.3_3 - 1.3 9.4 7.2 2.6 8.5 7.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3597) RRM_1 PF00076.20 MSTRG.20908.2_2 - 3.2e-30 103.6 0.5 6.9e-15 54.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.20908.2_2 - 6e-17 61.4 0.9 3.3e-08 33.4 0.2 2.4 2 0 0 2 2 2 2 RNA recognition motif CBFNT PF08143.9 MSTRG.20908.2_2 - 1.2e-05 26.4 4.6 1.2e-05 26.4 4.6 2.0 2 0 0 2 2 2 1 CBFNT (NUC161) domain Nup35_RRM_2 PF14605.4 MSTRG.20908.2_2 - 0.0013 18.5 0.0 0.026 14.4 0.0 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.9 MSTRG.20908.2_2 - 0.0047 16.8 0.3 1.3 9.0 0.1 2.5 2 0 0 2 2 2 2 RNA binding motif NID PF07292.11 MSTRG.20908.2_2 - 0.16 12.5 0.0 0.64 10.6 0.0 1.9 2 0 0 2 2 2 0 Nmi/IFP 35 domain (NID) DUF1732 PF08340.9 MSTRG.18986.3_3 - 0.032 14.1 0.0 0.079 12.8 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1732) IF-2B PF01008.15 MSTRG.23429.1_1 - 9e-89 297.3 0.0 1.5e-88 296.6 0.0 1.3 1 0 0 1 1 1 1 Initiation factor 2 subunit family Presenilin PF01080.15 MSTRG.23429.1_1 - 1.1 7.8 8.5 1.7 7.2 8.5 1.3 1 0 0 1 1 1 0 Presenilin Dimerisation2 PF16864.3 MSTRG.28088.1_1 - 4.2e-30 103.4 0.9 5.8e-30 103.0 0.9 1.2 1 0 0 1 1 1 1 Dimerisation domain SPRY PF00622.26 MSTRG.16689.2_3 - 2.8e-12 46.7 0.2 2e-05 24.5 0.0 2.5 2 0 0 2 2 2 2 SPRY domain RRM_1 PF00076.20 MSTRG.16576.1_1 - 3.5e-60 199.6 0.0 2e-21 75.5 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 MSTRG.16576.1_1 - 5.5e-08 32.4 0.0 0.00047 19.8 0.0 2.5 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_7 PF16367.3 MSTRG.16576.1_1 - 6.4e-06 26.1 0.1 0.69 9.9 0.0 3.7 3 1 0 3 3 3 2 RNA recognition motif Calcipressin PF04847.10 MSTRG.16576.1_1 - 0.00053 19.7 0.1 0.026 14.2 0.0 2.4 2 0 0 2 2 2 1 Calcipressin Pkinase PF00069.23 MSTRG.24141.1_1 - 8.6e-56 189.1 0.0 1.3e-55 188.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.24141.1_1 - 7.7e-37 126.8 0.0 1.1e-36 126.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.24141.1_1 - 3e-05 23.3 0.0 5.2e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.9 MSTRG.24141.1_1 - 0.0014 17.6 0.1 0.0024 16.9 0.1 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 APH PF01636.21 MSTRG.24141.1_1 - 0.087 12.6 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Rootletin PF15035.4 MSTRG.13943.1_1 - 2.3e-15 57.0 7.5 2.3e-15 57.0 7.5 3.0 2 1 0 2 2 2 1 Ciliary rootlet component, centrosome cohesion DUF759 PF05537.9 MSTRG.13943.1_1 - 0.045 12.5 0.2 5.4 5.6 0.0 2.1 2 0 0 2 2 2 0 Borrelia burgdorferi protein of unknown function (DUF759) Mod_r PF07200.11 MSTRG.13943.1_1 - 0.12 12.3 16.3 0.76 9.7 7.5 2.4 3 0 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein TMF_TATA_bd PF12325.6 MSTRG.13943.1_1 - 0.27 11.3 14.3 0.96 9.6 2.2 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Alb1 PF09135.9 MSTRG.13943.1_1 - 0.27 12.1 4.1 0.54 11.1 4.1 1.7 1 1 0 1 1 1 0 Alb1 Fib_alpha PF08702.8 MSTRG.13943.1_1 - 0.54 10.3 7.1 0.27 11.3 4.9 1.7 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.7 MSTRG.13943.1_1 - 0.61 10.3 9.1 0.19 11.9 0.7 2.2 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Phasin_2 PF09361.8 MSTRG.13943.1_1 - 0.75 10.0 6.8 0.41 10.8 4.4 1.7 2 0 0 2 2 2 0 Phasin protein OrfB_IS605 PF01385.17 MSTRG.13943.1_1 - 0.76 9.9 5.6 0.91 9.7 2.6 2.1 1 1 1 2 2 2 0 Probable transposase Helo_like_N PF17111.3 MSTRG.13943.1_1 - 0.89 8.7 6.5 0.38 9.9 2.0 2.2 1 1 0 2 2 2 0 Fungal N-terminal domain of STAND proteins DUF972 PF06156.11 MSTRG.13943.1_1 - 1.4 9.4 8.6 1.4e+02 3.0 7.1 2.8 1 1 0 1 1 1 0 Protein of unknown function (DUF972) Surfac_D-trimer PF09006.9 MSTRG.13943.1_1 - 1.6 8.5 7.1 4.3 7.2 2.6 2.6 2 1 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation DUF4407 PF14362.4 MSTRG.13943.1_1 - 3 7.0 11.2 4.4 6.4 11.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) BST2 PF16716.3 MSTRG.13943.1_1 - 5.1 7.6 14.6 3.6 8.1 4.6 3.1 1 1 3 4 4 4 0 Bone marrow stromal antigen 2 Sigma_1s PF02454.14 MSTRG.13943.1_2 - 0.028 14.3 0.1 0.058 13.2 0.1 1.5 1 0 0 1 1 1 0 Sigma 1s protein Beta_elim_lyase PF01212.19 MSTRG.19216.1_2 - 1.3e-88 297.0 1.1 1.7e-88 296.6 1.1 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.19 MSTRG.19216.1_2 - 5.3e-09 35.6 0.0 6.9e-09 35.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.15 MSTRG.19216.1_2 - 8.3e-05 21.9 0.5 0.0035 16.6 0.2 2.8 2 1 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.17 MSTRG.19216.1_2 - 0.00055 18.9 0.0 0.00088 18.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Fer4_8 PF13183.4 MSTRG.28844.1_1 - 0.0017 18.7 0.1 0.0025 18.1 0.1 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_17 PF13534.4 MSTRG.28844.1_1 - 0.013 15.8 0.1 0.021 15.2 0.1 1.3 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_10 PF13237.4 MSTRG.28844.1_1 - 0.043 13.8 0.1 0.054 13.5 0.1 1.3 1 0 0 1 1 1 0 4Fe-4S dicluster domain FHA PF00498.24 MSTRG.6854.3_3 - 7.5e-16 58.1 0.0 1.3e-15 57.3 0.0 1.4 1 0 0 1 1 1 1 FHA domain Aldolase_II PF00596.19 MSTRG.11435.7_1 - 1.3e-38 132.7 0.1 2e-38 132.1 0.1 1.3 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Nore1-SARAH PF16517.3 MSTRG.7632.2_1 - 1e-13 50.8 3.5 1e-13 50.8 3.5 2.0 2 0 0 2 2 2 1 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain RA PF00788.21 MSTRG.7632.2_1 - 2.6e-12 47.1 0.0 5.2e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Ras_bdg_2 PF14847.4 MSTRG.7632.2_1 - 0.0083 16.3 0.0 0.015 15.4 0.0 1.4 1 0 0 1 1 1 1 Ras-binding domain of Byr2 DUF4125 PF13526.4 MSTRG.7632.2_1 - 0.01 15.3 0.1 0.02 14.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4125) CpXC PF14353.4 MSTRG.7632.2_1 - 0.041 13.8 0.1 0.068 13.1 0.1 1.4 1 0 0 1 1 1 0 CpXC protein Neur_chan_LBD PF02931.21 MSTRG.24017.1_2 - 6e-46 156.5 0.0 8.8e-46 155.9 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 MSTRG.24017.1_2 - 2.9e-37 128.9 7.2 1.1e-30 107.3 5.1 2.2 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Pkinase PF00069.23 MSTRG.20478.1_1 - 2e-65 220.6 0.0 2.6e-65 220.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.20478.1_1 - 5.4e-34 117.5 0.0 8.1e-34 116.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PB1 PF00564.22 MSTRG.20478.1_1 - 3.6e-15 55.5 0.0 7.1e-15 54.6 0.0 1.5 1 0 0 1 1 1 1 PB1 domain C1_1 PF00130.20 MSTRG.20478.1_1 - 2.5e-14 52.8 5.5 7.1e-14 51.3 5.5 1.9 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.22 MSTRG.20478.1_1 - 4.3e-06 27.2 1.4 8.8e-06 26.2 1.4 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 MSTRG.20478.1_1 - 4.3e-05 22.9 0.0 6.4e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like C1_2 PF03107.14 MSTRG.20478.1_1 - 0.0079 16.3 2.1 0.021 15.0 2.1 1.7 1 0 0 1 1 1 1 C1 domain Kdo PF06293.12 MSTRG.20478.1_1 - 0.08 12.2 0.1 0.24 10.6 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 MSTRG.20478.1_1 - 0.12 12.1 0.2 0.46 10.2 0.2 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family UCR_UQCRX_QCR9 PF05365.10 MSTRG.24708.1_2 - 1.1e-25 89.1 0.6 1.5e-25 88.7 0.6 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Rad50_zn_hook PF04423.12 MSTRG.722.1_1 - 0.1 12.3 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Rad50 zinc hook motif UPF0731 PF14982.4 MSTRG.722.1_3 - 0.082 13.0 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 UPF0731 family PX PF00787.22 MSTRG.9825.1_2 - 3.4e-10 39.8 2.6 5.8e-10 39.0 2.6 1.4 1 0 0 1 1 1 1 PX domain Thioredoxin PF00085.18 MSTRG.940.5_3 - 6.5e-08 32.3 0.0 1.6e-07 31.1 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin OST3_OST6 PF04756.11 MSTRG.940.5_3 - 0.068 12.4 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family p450 PF00067.20 MSTRG.25625.1_2 - 2.1e-22 79.4 0.1 2.7e-22 79.0 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 Branch PF02485.19 MSTRG.26848.1_2 - 2.3e-51 174.5 0.1 3.5e-51 173.9 0.1 1.3 1 0 0 1 1 1 1 Core-2/I-Branching enzyme 7tm_2 PF00002.22 MSTRG.23367.1_1 - 9.1e-35 120.0 14.8 1.5e-34 119.3 14.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.19 MSTRG.23367.1_1 - 2.6e-14 53.5 1.5 2.6e-14 53.5 1.5 2.2 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif 7tm_1 PF00001.19 MSTRG.23367.1_1 - 0.99 8.4 8.6 1.9 7.5 8.6 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF4819 PF16090.3 MSTRG.4627.2_2 - 0.0059 16.5 0.2 2.1 8.3 0.0 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4819) Cadherin_tail PF15974.3 MSTRG.4627.2_2 - 0.022 14.9 0.5 4.4 7.5 0.0 2.3 2 0 0 2 2 2 0 Cadherin C-terminal cytoplasmic tail, catenin-binding region SH3-WW_linker PF16618.3 MSTRG.21327.8_2 - 2.9e-10 40.8 0.2 2.9e-10 40.8 0.2 2.5 3 0 0 3 3 3 1 Linker region between SH3 and WW domains on ARHGAP12 WW PF00397.24 MSTRG.21327.8_2 - 3.6e-10 39.5 6.8 7.6e-06 25.6 1.1 2.6 2 0 0 2 2 2 2 WW domain PH PF00169.27 MSTRG.21327.8_2 - 0.0026 18.1 0.1 0.0082 16.5 0.1 1.8 1 0 0 1 1 1 1 PH domain MAP7 PF05672.9 MSTRG.23400.4_3 - 1.9e-41 141.4 83.9 1.9e-41 141.4 83.9 4.3 3 2 0 3 3 3 1 MAP7 (E-MAP-115) family Transthyretin PF00576.19 MSTRG.21173.1_3 - 0.032 14.8 0.0 0.033 14.8 0.0 1.2 1 0 0 1 1 1 0 HIUase/Transthyretin family Phage_Mu_Gp45 PF06890.10 MSTRG.21173.1_3 - 0.095 12.2 0.1 0.28 10.7 0.0 1.7 1 1 1 2 2 2 0 Bacteriophage Mu Gp45 protein Bromodomain PF00439.23 MSTRG.10459.1_1 - 3e-10 39.9 0.1 9.1e-10 38.4 0.1 1.8 1 0 0 1 1 1 1 Bromodomain PWWP PF00855.15 MSTRG.10459.1_1 - 2.5e-09 37.3 0.6 2.5e-09 37.3 0.6 3.6 3 0 0 3 3 3 1 PWWP domain DUF2267 PF10025.7 MSTRG.10459.1_1 - 0.2 11.8 2.8 0.36 11.0 0.9 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2267) Sclerostin PF05463.9 MSTRG.392.1_3 - 2.7e-55 187.0 9.6 4.1e-55 186.5 9.6 1.1 1 0 0 1 1 1 1 Sclerostin (SOST) DAN PF03045.13 MSTRG.392.1_3 - 4.7e-22 78.0 2.6 4.7e-22 78.0 2.6 1.8 2 0 0 2 2 2 1 DAN domain Cys_knot PF00007.20 MSTRG.392.1_3 - 5.4e-05 23.3 3.7 0.0002 21.5 3.7 1.9 1 1 0 1 1 1 1 Cystine-knot domain Peptidase_M16_M PF16187.3 MSTRG.14689.1_2 - 1.2e-102 342.9 3.7 1.2e-102 342.9 3.7 1.6 2 0 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.18 MSTRG.14689.1_2 - 3.8e-47 159.9 0.2 3.1e-45 153.7 0.1 2.7 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.19 MSTRG.14689.1_2 - 1.4e-39 135.8 0.5 1.9e-22 80.0 0.0 2.8 3 0 0 3 3 3 2 Peptidase M16 inactive domain TMEM100 PF16311.3 MSTRG.12928.1_2 - 7.6e-35 119.3 0.1 1.1e-34 118.7 0.1 1.2 1 0 0 1 1 1 1 Transmembrane protein 100 NfeD PF01957.16 MSTRG.12928.1_2 - 0.0084 16.4 0.0 0.014 15.6 0.0 1.2 1 0 0 1 1 1 1 NfeD-like C-terminal, partner-binding TMEM51 PF15345.4 MSTRG.12928.1_2 - 0.091 12.5 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 Rap_GAP PF02145.13 MSTRG.3262.1_2 - 0.00025 20.6 0.0 0.093 12.2 0.0 3.0 3 0 0 3 3 3 2 Rap/ran-GAP A2M_comp PF07678.12 MSTRG.27450.1_3 - 3.6e-50 170.6 0.0 1.9e-49 168.2 0.0 2.0 1 1 0 1 1 1 1 A-macroglobulin complement component A2M PF00207.20 MSTRG.27450.1_3 - 2.3e-29 100.9 0.0 1.2e-28 98.6 0.0 2.4 2 0 0 2 2 2 1 Alpha-2-macroglobulin family A2M_N_2 PF07703.12 MSTRG.27450.1_3 - 8.4e-27 94.1 1.8 2.2e-24 86.2 0.1 3.4 3 0 0 3 3 3 1 Alpha-2-macroglobulin family N-terminal region A2M_recep PF07677.12 MSTRG.27450.1_3 - 1.6e-24 86.4 0.0 6.2e-24 84.5 0.0 2.1 1 0 0 1 1 1 1 A-macroglobulin receptor NTR PF01759.19 MSTRG.27450.1_3 - 1.3e-19 69.8 0.0 3.6e-19 68.4 0.0 1.7 1 0 0 1 1 1 1 UNC-6/NTR/C345C module A2M_N PF01835.17 MSTRG.27450.1_3 - 7.4e-17 61.5 0.1 5e-16 58.8 0.1 2.4 2 0 0 2 2 2 1 MG2 domain ANATO PF01821.16 MSTRG.27450.1_3 - 1.3e-08 35.4 5.4 1.3e-08 35.4 5.4 2.7 3 0 0 3 3 3 1 Anaphylotoxin-like domain Thiol-ester_cl PF10569.7 MSTRG.27450.1_3 - 2.9e-08 33.1 1.8 3.4e-08 32.9 0.2 2.0 2 0 0 2 2 2 1 Alpha-macro-globulin thiol-ester bond-forming region lci PF12197.6 MSTRG.27450.1_3 - 0.043 13.5 0.3 0.097 12.4 0.3 1.6 1 0 0 1 1 1 0 Bacillus cereus group antimicrobial protein Glyco_hydro_66 PF13199.4 MSTRG.27450.1_3 - 0.061 11.8 0.0 0.18 10.3 0.0 1.7 2 0 0 2 2 2 0 Glycosyl hydrolase family 66 zf-C2H2 PF00096.24 MSTRG.11635.1_2 - 3.7e-43 143.5 151.0 1.6e-05 25.0 1.1 17.3 17 0 0 17 17 17 13 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.11635.1_2 - 4.5e-40 134.2 150.4 3.6e-09 36.5 3.7 17.9 18 0 0 18 18 18 12 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.11635.1_2 - 1.9e-21 74.8 155.1 0.0039 17.8 0.9 18.5 19 0 0 19 19 19 14 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.11635.1_2 - 3.2e-12 46.3 91.7 0.0055 16.8 0.0 15.3 16 0 0 16 16 16 8 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.11635.1_2 - 2.3e-06 27.7 99.4 0.017 15.4 0.1 15.0 15 0 0 15 15 15 9 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 MSTRG.11635.1_2 - 0.001 18.9 1.0 0.001 18.9 1.0 15.3 16 0 0 16 16 16 7 C2H2-type zinc finger API5 PF05918.9 MSTRG.11635.1_2 - 0.11 11.1 1.4 0.17 10.5 1.4 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Crystall PF00030.17 MSTRG.26696.1_2 - 1e-59 198.5 5.0 1.2e-30 105.4 0.2 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 MSTRG.26696.1_2 - 1.2e-07 31.4 1.1 0.0013 18.5 0.0 2.7 3 0 0 3 3 3 2 Peptidase inhibitor family I36 Crystall_3 PF08964.8 MSTRG.26696.1_2 - 0.00077 19.5 0.1 9.5 6.3 0.0 3.4 3 1 0 3 3 3 2 Beta/Gamma crystallin Exo70 PF03081.13 MSTRG.10181.2_3 - 4.1e-75 253.1 5.0 4.1e-75 253.1 5.0 1.5 2 0 0 2 2 2 1 Exo70 exocyst complex subunit Sec34 PF04136.13 MSTRG.10181.2_3 - 0.011 15.5 1.5 0.051 13.3 1.5 2.2 1 0 0 1 1 1 0 Sec34-like family RolB_RolC PF02027.15 MSTRG.10181.2_3 - 0.079 12.5 0.5 0.2 11.2 0.5 1.8 1 1 0 1 1 1 0 RolB/RolC glucosidase family IZUMO PF15005.4 MSTRG.10181.2_3 - 0.3 11.5 4.3 3.8 7.9 0.1 3.8 4 0 0 4 4 4 0 Izumo sperm-egg fusion, Ig domain-associated LMBR1 PF04791.14 MSTRG.10181.2_3 - 1.6 7.4 6.1 0.96 8.1 0.7 2.5 2 1 0 2 2 2 0 LMBR1-like membrane protein Exonuc_VII_L PF02601.13 MSTRG.10181.2_3 - 2.4 7.5 4.8 0.87 9.0 0.2 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit LEDGF PF11467.6 MSTRG.27638.1_2 - 2.2e-23 82.0 1.5 3.8e-23 81.3 1.5 1.3 1 0 0 1 1 1 1 Lens epithelium-derived growth factor (LEDGF) Med26 PF08711.9 MSTRG.27638.1_2 - 0.033 14.1 0.3 0.064 13.2 0.3 1.4 1 0 0 1 1 1 0 TFIIS helical bundle-like domain XRCC4 PF06632.10 MSTRG.27638.1_2 - 0.051 12.3 5.8 0.082 11.6 5.8 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 BCL9 PF11502.6 MSTRG.27638.1_2 - 5.8 6.7 6.7 3.7 7.3 1.3 2.4 2 0 0 2 2 2 0 B-cell lymphoma 9 protein zf-H2C2_2 PF13465.4 MSTRG.8659.1_2 - 3.2e-18 65.1 23.2 3.1e-08 33.6 1.1 4.9 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.8659.1_2 - 3.5e-17 61.7 28.3 3.5e-05 23.9 2.2 5.9 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.8659.1_2 - 1e-08 35.1 26.6 0.17 12.6 1.8 6.0 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2_8 PF15909.3 MSTRG.8659.1_2 - 9e-05 22.6 14.7 0.027 14.7 4.0 3.5 1 1 2 3 3 3 3 C2H2-type zinc ribbon zf-C2HC_2 PF13913.4 MSTRG.8659.1_2 - 0.029 14.1 7.0 3.7 7.4 1.2 4.4 4 0 0 4 4 4 0 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.6 MSTRG.8659.1_2 - 0.094 12.9 11.6 2.5 8.4 0.6 4.5 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.3 MSTRG.8659.1_2 - 0.26 11.8 8.7 5.3 7.6 0.1 4.3 3 1 1 4 4 4 0 FOXP coiled-coil domain zf-met PF12874.5 MSTRG.8659.1_2 - 0.43 10.9 20.0 1.1 9.6 1.8 4.6 4 0 0 4 4 4 0 Zinc-finger of C2H2 type FlpD PF02662.14 MSTRG.3128.1_1 - 0.08 12.8 1.1 12 5.7 0.2 2.4 2 0 0 2 2 2 0 Methyl-viologen-reducing hydrogenase, delta subunit VMA21 PF09446.8 MSTRG.3128.1_2 - 1.1 9.3 12.5 6.1 6.9 1.0 3.8 3 0 0 3 3 3 0 VMA21-like domain Stealth_CR2 PF11380.6 MSTRG.15230.1_3 - 3.3e-46 155.8 0.2 5.5e-46 155.1 0.2 1.4 1 0 0 1 1 1 1 Stealth protein CR2, conserved region 2 Stealth_CR1 PF17101.3 MSTRG.15230.1_3 - 1.7e-11 43.5 0.0 3.4e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 Stealth protein CR1, conserved region 1 Notch PF00066.15 MSTRG.15230.1_3 - 1.5e-09 38.0 13.7 2.7e-09 37.2 13.7 1.4 1 0 0 1 1 1 1 LNR domain Pkinase_Tyr PF07714.15 MSTRG.23295.2_1 - 1.6e-79 266.7 0.0 2.1e-79 266.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.23295.2_1 - 9.8e-38 129.9 0.0 7.3e-37 127.0 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain F5_F8_type_C PF00754.23 MSTRG.23295.2_1 - 9.6e-21 74.1 0.0 1.6e-20 73.4 0.0 1.4 1 0 0 1 1 1 1 F5/8 type C domain Mid2 PF04478.10 MSTRG.23295.2_1 - 0.15 11.8 0.2 0.31 10.7 0.2 1.5 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Ank_5 PF13857.4 MSTRG.7193.1_1 - 0.11 12.7 0.0 9.9 6.6 0.0 2.4 2 0 0 2 2 2 0 Ankyrin repeats (many copies) MTABC_N PF16185.3 MSTRG.24477.1_3 - 0.00075 19.0 1.2 0.0011 18.4 1.2 1.2 1 0 0 1 1 1 1 Mitochondrial ABC-transporter N-terminal five TM region Frag1 PF10277.7 MSTRG.24477.1_3 - 0.0051 16.2 0.6 0.0051 16.2 0.6 1.6 1 1 1 2 2 2 1 Frag1/DRAM/Sfk1 family MARVEL PF01284.21 MSTRG.24477.1_3 - 0.66 9.9 10.5 0.14 12.1 5.5 2.3 1 1 1 2 2 2 0 Membrane-associating domain DUF3040 PF11239.6 MSTRG.24477.1_3 - 1.2 9.3 5.9 1.6 8.9 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Ras PF00071.20 MSTRG.19208.1_1 - 4.9e-46 156.2 0.0 6.6e-46 155.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.19208.1_1 - 1.3e-28 99.5 0.0 2e-28 98.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.19208.1_1 - 7.7e-14 51.4 0.0 1.1e-13 50.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 MSTRG.19208.1_1 - 5.2e-09 35.7 0.0 6.8e-09 35.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 MSTRG.19208.1_1 - 7.6e-05 22.1 0.0 0.00013 21.4 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 MSTRG.19208.1_1 - 0.00018 21.5 0.0 0.00027 20.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.18 MSTRG.19208.1_1 - 0.00042 19.4 0.1 0.0042 16.2 0.0 2.3 1 1 1 2 2 2 1 G-protein alpha subunit PduV-EutP PF10662.7 MSTRG.19208.1_1 - 0.00072 19.2 0.0 0.0012 18.5 0.0 1.3 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.25 MSTRG.19208.1_1 - 0.00092 18.7 0.1 0.11 11.8 0.0 2.1 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain Ank_4 PF13637.4 MSTRG.21878.1_1 - 2.7e-29 101.0 3.3 1.9e-06 28.2 0.1 4.7 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.5 MSTRG.21878.1_1 - 7.4e-29 100.0 3.1 5.5e-14 52.4 0.1 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.21878.1_1 - 1.2e-28 98.5 8.4 1.9e-10 40.6 0.9 4.5 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.21878.1_1 - 4.1e-24 83.8 14.4 1.3e-05 25.3 0.2 6.7 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.4 MSTRG.21878.1_1 - 1.8e-18 64.6 4.9 0.007 16.7 0.0 6.0 6 0 0 6 6 6 4 Ankyrin repeat SMC_ScpB PF04079.14 MSTRG.21878.1_1 - 0.024 14.1 0.0 0.046 13.2 0.0 1.3 1 0 0 1 1 1 0 Segregation and condensation complex subunit ScpB Quaking_NLS PF16551.3 MSTRG.8675.4_1 - 5.9e-16 57.7 5.3 1.3e-15 56.6 5.3 1.6 1 0 0 1 1 1 1 Putative nuclear localisation signal of quaking STAR_dimer PF16544.3 MSTRG.8675.4_3 - 3.3e-23 80.9 0.1 6.4e-23 79.9 0.1 1.5 1 0 0 1 1 1 1 Homodimerisation region of STAR domain protein KH_1 PF00013.27 MSTRG.8675.4_3 - 1.7e-05 24.4 0.0 3.4e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 KH domain ADH_zinc_N_2 PF13602.4 MSTRG.1193.1_1 - 1.7e-23 84.0 0.1 2.5e-23 83.4 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.24 MSTRG.1193.1_1 - 6.9e-11 42.0 0.1 2.6e-10 40.2 0.0 1.9 1 1 1 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.10 MSTRG.1193.1_1 - 3.1e-05 23.7 0.0 6.6e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain SepZ PF06066.9 MSTRG.1193.1_1 - 0.0055 16.8 1.0 0.04 14.0 0.3 2.2 2 0 0 2 2 2 1 SepZ ELFV_dehydrog PF00208.19 MSTRG.1193.1_1 - 0.041 13.5 0.2 0.068 12.8 0.2 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase AlaDh_PNT_C PF01262.19 MSTRG.1193.1_1 - 0.06 12.5 0.5 0.096 11.8 0.5 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain adh_short PF00106.23 MSTRG.1193.1_1 - 0.073 12.4 0.3 0.15 11.3 0.3 1.5 1 0 0 1 1 1 0 short chain dehydrogenase NAD_binding_7 PF13241.4 MSTRG.1193.1_1 - 0.12 12.7 0.0 0.22 11.9 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding UT PF03253.12 MSTRG.3315.1_1 - 6.8e-59 199.3 22.4 9.1e-59 198.8 22.4 1.2 1 0 0 1 1 1 1 Urea transporter MH2 PF03166.12 MSTRG.16573.1_2 - 4.2e-79 264.9 0.1 6.6e-79 264.3 0.1 1.3 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.14 MSTRG.16573.1_2 - 2.3e-42 143.3 2.0 6.6e-42 141.8 2.0 1.9 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.7 MSTRG.16573.1_2 - 0.013 15.2 0.0 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 Interferon-regulatory factor 3 GRAM PF02893.18 MSTRG.14502.1_1 - 1e-15 57.4 0.0 2e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 GRAM domain PRT_C PF08372.8 MSTRG.14502.1_1 - 0.00089 18.9 0.7 0.0027 17.4 0.0 2.1 2 0 0 2 2 2 1 Plant phosphoribosyltransferase C-terminal Phage-scaffold PF09306.8 MSTRG.14502.1_1 - 0.0013 18.0 0.3 0.0022 17.3 0.3 1.3 1 0 0 1 1 1 1 Bacteriophage, scaffolding protein Reticulon PF02453.15 MSTRG.14502.1_1 - 0.035 13.9 0.6 0.16 11.8 1.2 1.7 2 0 0 2 2 2 0 Reticulon Tmemb_cc2 PF10267.7 MSTRG.14502.1_1 - 0.34 9.9 6.1 0.58 9.1 6.1 1.3 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein HABP4_PAI-RBP1 PF04774.13 MSTRG.14502.1_1 - 0.41 11.4 2.5 0.82 10.4 2.5 1.5 1 0 0 1 1 1 0 Hyaluronan / mRNA binding family CAP_N PF01213.17 MSTRG.14502.1_2 - 0.27 10.5 3.0 0.69 9.2 3.0 1.6 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal EF-hand_1 PF00036.30 MSTRG.3538.4_1 - 5.1e-16 56.8 0.2 3.1e-05 23.1 0.0 4.5 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.4 MSTRG.3538.4_1 - 1.1e-12 47.4 1.7 9.9e-09 34.7 0.1 3.8 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.3538.4_1 - 3.4e-12 45.1 0.1 3.3e-05 23.3 0.0 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.4 MSTRG.3538.4_1 - 2.9e-10 40.4 0.0 7.4e-05 23.0 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.3538.4_1 - 6.6e-07 28.4 1.0 0.045 13.2 0.0 3.4 3 0 0 3 3 3 2 EF hand Ribosomal_S25 PF03297.13 MSTRG.4332.3_3 - 2.1e-48 162.5 3.8 2.9e-48 162.1 3.8 1.1 1 0 0 1 1 1 1 S25 ribosomal protein AIPR PF10592.7 MSTRG.4332.3_3 - 0.055 13.0 0.6 0.076 12.5 0.6 1.3 1 1 0 1 1 1 0 AIPR protein TrmB PF01978.17 MSTRG.4332.3_3 - 0.11 12.3 0.4 0.18 11.6 0.2 1.5 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Rtt106 PF08512.10 MSTRG.892.1_2 - 0.038 14.3 0.0 0.061 13.6 0.0 1.2 1 0 0 1 1 1 0 Histone chaperone Rttp106-like REPA_OB_2 PF16900.3 MSTRG.892.1_3 - 2.2e-31 107.5 0.0 6.8e-31 106.0 0.0 1.8 2 0 0 2 2 2 1 Replication protein A OB domain Rep_fac-A_C PF08646.8 MSTRG.892.1_3 - 4.1e-31 107.6 4.8 3.2e-29 101.4 2.4 3.1 2 1 0 2 2 2 1 Replication factor-A C terminal domain Rep-A_N PF04057.10 MSTRG.892.1_3 - 2.8e-16 59.3 0.0 4.7e-16 58.5 0.0 1.4 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.23 MSTRG.892.1_3 - 8.5e-11 41.6 0.1 1.8e-09 37.4 0.1 2.8 3 0 0 3 3 3 1 OB-fold nucleic acid binding domain zf-HIT PF04438.14 MSTRG.892.1_3 - 0.033 13.9 3.4 0.14 11.9 3.4 2.2 1 0 0 1 1 1 0 HIT zinc finger Daxx PF03344.13 MSTRG.18832.5_2 - 4.3e-35 119.6 2.9 9.6e-35 118.5 2.9 1.6 1 0 0 1 1 1 1 Daxx N-terminal Rassf1C-interacting domain Kazal_1 PF00050.19 MSTRG.14328.1_1 - 6.7e-15 54.7 4.3 1.2e-14 53.9 4.3 1.4 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.13 MSTRG.14328.1_1 - 1.1e-11 44.5 2.7 2.2e-11 43.6 2.7 1.5 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain DUF3338 PF11819.6 MSTRG.13062.1_1 - 4.7e-51 172.2 4.4 1.4e-50 170.7 4.4 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3338) FERM_C PF09380.8 MSTRG.13062.1_1 - 1.3e-22 79.8 0.2 3e-22 78.7 0.2 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.16 MSTRG.13062.1_1 - 4.2e-19 69.0 0.0 1.3e-18 67.4 0.0 1.9 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.8 MSTRG.13062.1_1 - 1e-07 31.7 1.2 2.1e-07 30.7 0.2 2.0 2 0 0 2 2 2 1 FERM N-terminal domain zf-H2C2_2 PF13465.4 MSTRG.4580.1_1 - 0.093 13.1 1.5 0.093 13.1 1.5 2.1 2 1 0 2 2 2 0 Zinc-finger double domain PI-PLC-X PF00388.17 MSTRG.23990.1_3 - 0.088 12.3 0.0 0.27 10.7 0.0 1.8 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain zf-C2H2 PF00096.24 MSTRG.1812.1_3 - 5.2e-06 26.5 127.9 0.025 14.9 1.4 14.6 14 0 0 14 14 14 9 Zinc finger, C2H2 type AF0941-like PF14591.4 MSTRG.1812.1_3 - 0.0013 19.1 0.0 0.0062 16.9 0.0 2.2 1 0 0 1 1 1 1 AF0941-like zf-C2H2_4 PF13894.4 MSTRG.1812.1_3 - 0.0015 19.1 122.9 0.044 14.5 2.2 15.6 15 0 0 15 15 15 10 C2H2-type zinc finger Ldl_recept_a PF00057.16 MSTRG.25618.3_1 - 3.2e-278 897.5 611.5 3.5e-10 39.8 8.2 38.2 34 4 4 38 38 38 37 Low-density lipoprotein receptor domain class A FXa_inhibition PF14670.4 MSTRG.25618.3_1 - 3.4e-18 65.5 52.8 6.1e-10 39.1 5.9 19.4 21 0 0 21 21 21 6 Coagulation Factor Xa inhibitory site Ldl_recept_b PF00058.15 MSTRG.25618.3_1 - 1e-15 57.8 4.4 0.0053 17.1 0.0 8.1 7 0 0 7 7 7 4 Low-density lipoprotein receptor repeat class B EGF_CA PF07645.13 MSTRG.25618.3_1 - 2.2e-10 40.4 24.2 3.1e-07 30.4 7.9 33.5 30 8 10 40 40 40 2 Calcium-binding EGF domain cEGF PF12662.5 MSTRG.25618.3_1 - 9.5e-09 34.9 8.5 3.2e-06 26.8 0.7 13.5 12 0 0 12 12 12 4 Complement Clr-like EGF-like EGF PF00008.25 MSTRG.25618.3_1 - 0.0024 18.0 7.3 0.0024 18.0 7.3 24.0 26 1 0 26 26 26 7 EGF-like domain Ank_4 PF13637.4 MSTRG.26220.3_1 - 3.1e-18 65.8 0.1 7.1e-14 51.9 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 MSTRG.26220.3_1 - 4.6e-17 62.3 0.0 9.2e-17 61.3 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.28 MSTRG.26220.3_1 - 4e-13 49.0 0.1 5.3e-05 23.4 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.4 MSTRG.26220.3_1 - 7.9e-13 47.2 0.1 5e-05 23.3 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat SH3_1 PF00018.26 MSTRG.26220.3_1 - 1.2e-11 43.9 0.9 2e-11 43.2 0.9 1.4 1 0 0 1 1 1 1 SH3 domain Ank_5 PF13857.4 MSTRG.26220.3_1 - 1e-09 38.4 0.4 4.8e-08 33.0 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SH3_2 PF07653.15 MSTRG.26220.3_1 - 7.3e-08 31.9 0.1 1.5e-07 30.8 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 MSTRG.26220.3_1 - 8e-08 31.9 1.6 1.1e-07 31.5 0.3 1.9 2 0 0 2 2 2 1 Variant SH3 domain HLH PF00010.24 MSTRG.21700.1_2 - 9.1e-12 44.6 0.9 3.2e-11 42.9 1.0 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain 7tm_1 PF00001.19 MSTRG.14500.1_3 - 2.2e-69 233.5 2.2 3e-69 233.1 2.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 MSTRG.14500.1_3 - 5.5e-12 45.5 5.9 2e-06 27.3 2.9 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 MSTRG.14500.1_3 - 6.7e-05 22.6 6.3 9.4e-05 22.1 2.1 2.1 2 0 0 2 2 2 1 Olfactory receptor Cytochrom_B558a PF05038.11 MSTRG.14500.1_3 - 0.21 11.0 0.1 0.21 11.0 0.1 2.0 2 0 0 2 2 2 0 Cytochrome Cytochrome b558 alpha-subunit 2-Hacid_dh_C PF02826.17 MSTRG.10270.3_2 - 5.3e-58 195.2 0.0 7.1e-58 194.7 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.28 MSTRG.10270.3_2 - 2.2e-28 98.4 0.0 2.8e-28 98.1 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.13 MSTRG.10270.3_2 - 0.00023 21.2 0.0 0.0004 20.4 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.18 MSTRG.10270.3_2 - 0.0061 16.5 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.15 MSTRG.10270.3_2 - 0.019 15.4 0.0 0.044 14.2 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent KR PF08659.8 MSTRG.10270.3_2 - 0.051 13.4 0.0 0.094 12.5 0.0 1.5 1 0 0 1 1 1 0 KR domain ThiF PF00899.19 MSTRG.10270.3_2 - 0.38 9.9 3.1 0.49 9.6 1.1 1.9 2 0 0 2 2 2 0 ThiF family Sulfotransfer_2 PF03567.12 MSTRG.5101.1_2 - 6.2e-69 232.6 3.6 7.9e-69 232.2 3.6 1.1 1 0 0 1 1 1 1 Sulfotransferase family ATP-synt_ab_N PF02874.21 MSTRG.29345.1_2 - 1.9e-24 85.9 1.4 2.6e-24 85.4 1.4 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain CDC37_N PF03234.12 MSTRG.10934.1_1 - 4.8e-11 43.5 17.3 1.2e-10 42.3 17.3 1.7 1 1 0 1 1 1 1 Cdc37 N terminal kinase binding CDC37_M PF08565.9 MSTRG.10934.1_1 - 3.7e-05 23.5 0.0 9e-05 22.2 0.0 1.7 1 1 0 1 1 1 1 Cdc37 Hsp90 binding domain Laminin_II PF06009.10 MSTRG.10934.1_1 - 0.16 11.8 3.7 0.27 11.1 3.7 1.3 1 0 0 1 1 1 0 Laminin Domain II FlaC_arch PF05377.9 MSTRG.10934.1_1 - 0.22 11.8 2.6 0.54 10.5 2.6 1.7 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) PRKG1_interact PF15898.3 MSTRG.10934.1_1 - 4.4 8.2 15.2 9.4 7.1 7.3 2.3 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain CDC37_C PF08564.8 MSTRG.10934.1_2 - 1e-17 63.9 0.9 1e-17 63.9 0.9 1.6 1 1 0 1 1 1 1 Cdc37 C terminal domain CDC37_M PF08565.9 MSTRG.10934.1_2 - 9.5e-15 54.4 1.1 1.5e-14 53.8 1.1 1.2 1 0 0 1 1 1 1 Cdc37 Hsp90 binding domain MTCP1 PF08991.8 MSTRG.10934.1_3 - 5.1e-14 52.1 10.3 5.1e-14 52.1 10.3 2.3 2 0 0 2 2 2 1 Mature-T-Cell Proliferation I type Curto_V3 PF07436.9 MSTRG.5846.1_3 - 0.18 11.9 0.0 0.3 11.2 0.0 1.2 1 0 0 1 1 1 0 Curtovirus V3 protein zf-C2HC_2 PF13913.4 MSTRG.21873.2_1 - 5.2e-14 51.6 8.0 6e-08 32.3 1.2 2.9 2 0 0 2 2 2 2 zinc-finger of a C2HC-type CAP_N PF01213.17 MSTRG.21873.2_1 - 0.058 12.7 1.4 0.11 11.9 1.4 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal FYVE PF01363.19 MSTRG.21873.2_1 - 3.4 7.7 15.8 9.9 6.2 0.1 3.3 3 0 0 3 3 3 0 FYVE zinc finger DZR PF12773.5 MSTRG.21873.2_1 - 3.5 7.6 19.9 0.63 10.0 5.9 3.9 4 0 0 4 4 4 0 Double zinc ribbon zinc_ribbon_2 PF13240.4 MSTRG.21873.2_1 - 4.7 6.9 13.1 1.2 8.8 6.8 2.7 2 0 0 2 2 2 0 zinc-ribbon domain SIR2 PF02146.15 MSTRG.2408.2_3 - 1.3e-52 178.1 0.0 1.8e-52 177.7 0.0 1.2 1 0 0 1 1 1 1 Sir2 family G-alpha PF00503.18 MSTRG.8955.2_3 - 1.3e-48 165.8 0.1 1.9e-48 165.3 0.1 1.1 1 0 0 1 1 1 1 G-protein alpha subunit RhoGAP PF00620.25 MSTRG.422.2_3 - 7.8e-47 158.8 0.0 1.2e-46 158.1 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain WW PF00397.24 MSTRG.422.2_3 - 8.5e-18 63.9 18.6 1.7e-09 37.3 0.2 4.0 4 0 0 4 4 4 3 WW domain PH_9 PF15410.4 MSTRG.422.2_3 - 1.2e-06 28.8 0.2 2.3e-06 27.8 0.2 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 MSTRG.422.2_3 - 2.2e-06 28.0 0.8 5.6e-06 26.7 0.2 2.0 2 0 0 2 2 2 1 PH domain NAC PF01849.16 MSTRG.20352.2_1 - 3.2e-24 84.6 0.3 1.2e-23 82.7 0.3 2.1 1 0 0 1 1 1 1 NAC domain RNA_pol_Rpo13 PF12136.6 MSTRG.20352.2_1 - 0.46 10.3 3.9 1 9.2 3.9 1.6 1 0 0 1 1 1 0 RNA polymerase Rpo13 subunit HTH domain MMM1 PF10296.7 MSTRG.2577.1_2 - 6.2e-06 25.3 0.0 8.9e-06 24.8 0.0 1.1 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 DUF2870 PF11069.6 MSTRG.880.1_1 - 1.2e-45 153.6 4.6 2.4e-45 152.7 4.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2870) SH3_9 PF14604.4 MSTRG.5304.1_1 - 7.5e-17 60.8 0.2 1.7e-16 59.7 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.5304.1_1 - 2.8e-14 52.3 0.0 4.4e-14 51.7 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.5304.1_1 - 5.7e-11 41.8 0.1 2.5e-10 39.7 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain Abi_HHR PF07815.12 MSTRG.5304.1_3 - 6.5e-25 86.9 0.0 1.2e-24 86.1 0.0 1.4 1 0 0 1 1 1 1 Abl-interactor HHR PHO4 PF01384.18 MSTRG.4642.1_3 - 1.4e-135 451.6 1.2 1.4e-135 451.6 1.2 1.7 2 0 0 2 2 2 1 Phosphate transporter family PID PF00640.21 MSTRG.23798.1_1 - 1.3e-08 34.8 0.1 2.1e-08 34.2 0.1 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) NicO PF03824.14 MSTRG.23798.1_1 - 2.3 7.4 5.5 7.6 5.6 5.5 1.7 2 0 0 2 2 2 0 High-affinity nickel-transport protein SelP_N PF04592.12 MSTRG.23798.1_1 - 4.4 6.5 21.1 10 5.3 21.1 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Mcl1_mid PF12341.6 MSTRG.1685.1_1 - 0.11 11.7 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 Minichromosome loss protein, Mcl1, middle region SH2 PF00017.22 MSTRG.6957.4_2 - 5.2e-22 77.6 0.0 8.1e-22 77.0 0.0 1.3 1 0 0 1 1 1 1 SH2 domain SH2_2 PF14633.4 MSTRG.6957.4_2 - 0.041 13.2 0.0 0.065 12.5 0.0 1.3 1 0 0 1 1 1 0 SH2 domain COX5A PF02284.14 MSTRG.6957.4_2 - 0.16 11.9 0.0 0.24 11.3 0.0 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Va SlyX PF04102.10 MSTRG.20900.1_1 - 0.047 14.2 14.4 0.42 11.1 0.3 4.5 3 1 0 3 3 3 0 SlyX Spc7 PF08317.9 MSTRG.20900.1_1 - 0.22 10.2 15.2 0.67 8.6 15.2 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF16 PF01519.14 MSTRG.20900.1_1 - 0.28 11.6 8.2 2.6 8.4 1.7 3.5 4 0 0 4 4 3 0 Protein of unknown function DUF16 Leu_zip PF15294.4 MSTRG.20900.1_1 - 0.44 9.9 10.1 1.2 8.5 9.2 2.0 1 1 0 1 1 1 0 Leucine zipper Laminin_II PF06009.10 MSTRG.20900.1_1 - 0.68 9.8 7.9 8.7 6.2 5.1 3.1 2 1 2 4 4 4 0 Laminin Domain II DUF812 PF05667.9 MSTRG.20900.1_1 - 0.7 8.6 12.4 0.02 13.7 6.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF812) GAS PF13851.4 MSTRG.20900.1_1 - 1 8.5 21.9 3 7.0 0.3 3.3 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Fib_alpha PF08702.8 MSTRG.20900.1_1 - 1.1 9.2 17.1 0.062 13.3 8.8 2.7 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family TSC22 PF01166.16 MSTRG.20900.1_1 - 1.6 9.0 6.3 1.1 9.5 0.2 3.2 2 1 1 3 3 3 0 TSC-22/dip/bun family AAA_13 PF13166.4 MSTRG.20900.1_1 - 3.7 6.0 9.4 6.4 5.2 9.4 1.3 1 0 0 1 1 1 0 AAA domain DUF2009 PF09418.8 MSTRG.20900.1_1 - 9.8 5.0 7.4 1.4 7.8 3.4 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2009) NTP_transf_7 PF07984.10 MSTRG.17218.1_2 - 7.5e-157 521.4 0.1 9e-157 521.2 0.1 1.1 1 0 0 1 1 1 1 Nucleotidyltransferase DUF1803 PF08820.8 MSTRG.17218.1_2 - 0.13 12.2 0.2 0.36 10.8 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1803) CAP_GLY PF01302.23 MSTRG.8125.1_3 - 1.5e-30 104.8 0.1 6.7e-14 51.5 0.0 3.3 3 0 0 3 3 3 3 CAP-Gly domain UCH_1 PF13423.4 MSTRG.8125.1_3 - 0.14 11.6 0.1 14 5.1 0.0 2.3 2 0 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase Glyco_hydro_20 PF00728.20 MSTRG.17136.1_1 - 2.3e-88 296.9 0.0 3.1e-88 296.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.4 MSTRG.17136.1_1 - 9.5e-15 55.3 0.0 1.9e-14 54.3 0.0 1.5 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.13 MSTRG.17136.1_1 - 0.09 13.5 0.0 0.2 12.4 0.0 1.6 1 1 0 1 1 1 0 Glycosyl hydrolase family 20, domain 2 MFS_1 PF07690.14 MSTRG.16488.3_3 - 8e-30 103.8 45.4 5.2e-18 65.0 30.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily FAM110_N PF14161.4 MSTRG.15104.1_1 - 3.7 7.6 11.0 4.9 7.3 0.4 3.6 2 2 1 3 3 3 0 Centrosome-associated N terminus LIM PF00412.20 MSTRG.15104.1_2 - 2.5e-40 136.4 71.8 7.1e-12 45.3 6.2 7.2 7 0 0 7 7 7 6 LIM domain MFS_1 PF07690.14 MSTRG.9829.1_1 - 1.8e-35 122.4 35.5 2.1e-28 99.1 19.9 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 MSTRG.9829.1_1 - 1.3e-29 103.3 13.6 3.1e-27 95.4 2.6 3.1 3 0 0 3 3 3 2 Sugar (and other) transporter MFS_4 PF06779.12 MSTRG.9829.1_1 - 2e-05 24.0 22.3 0.0021 17.3 8.0 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB MFS_1_like PF12832.5 MSTRG.9829.1_1 - 0.017 13.9 9.9 0.2 10.3 1.9 3.1 2 1 0 2 2 2 0 MFS_1 like family Sel1 PF08238.10 MSTRG.27972.1_3 - 0.0032 17.9 0.1 0.0074 16.8 0.1 1.6 1 0 0 1 1 1 1 Sel1 repeat DUF4214 PF13946.4 MSTRG.23686.1_3 - 0.13 12.0 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4214) Sulfatase_C PF14707.4 MSTRG.21330.1_1 - 0.048 14.2 0.1 0.098 13.2 0.0 1.5 2 0 0 2 2 2 0 C-terminal region of aryl-sulfatase zf-Tim10_DDP PF02953.13 MSTRG.7268.1_1 - 3.2e-23 81.0 2.4 5.4e-23 80.3 2.4 1.4 1 0 0 1 1 1 1 Tim10/DDP family zinc finger MA-Mit PF09245.8 MSTRG.7268.1_1 - 0.13 11.6 0.1 0.31 10.4 0.0 1.5 2 0 0 2 2 2 0 Mycoplasma arthritidis-derived mitogen MIF4G PF02854.17 MSTRG.21256.1_1 - 3.8e-63 212.9 10.0 7.3e-63 211.9 10.0 1.5 1 0 0 1 1 1 1 MIF4G domain MA3 PF02847.15 MSTRG.21256.1_1 - 9.2e-23 80.3 0.0 3.8e-22 78.3 0.0 2.1 2 0 0 2 2 2 1 MA3 domain W2 PF02020.16 MSTRG.21256.1_1 - 1.3e-17 63.6 1.2 5.5e-17 61.5 1.2 2.1 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon IL22 PF14565.4 MSTRG.21256.1_1 - 6.3 6.9 6.1 4.8 7.3 0.5 2.7 3 0 0 3 3 3 0 Interleukin 22 IL-10-related T-cell-derived-inducible factor Frizzled PF01534.15 MSTRG.25658.1_3 - 1.2e-118 395.8 14.3 1.6e-118 395.4 14.3 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.20 MSTRG.25658.1_3 - 7.8e-29 100.5 8.0 1.9e-28 99.3 8.0 1.7 1 0 0 1 1 1 1 Fz domain BTB PF00651.29 MSTRG.5071.1_1 - 2.5e-23 82.3 0.0 4e-23 81.6 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 MSTRG.5071.1_1 - 2.5e-07 30.7 12.3 0.00047 20.4 1.4 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.5071.1_1 - 0.0008 19.6 5.7 0.0008 19.6 5.7 5.0 5 0 0 5 5 5 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.5071.1_1 - 0.0051 17.4 3.7 0.0051 17.4 3.7 5.2 4 0 0 4 4 4 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.5071.1_1 - 0.014 15.5 0.8 0.014 15.5 0.8 2.9 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 MSTRG.5071.1_1 - 0.048 13.5 8.6 0.02 14.7 3.1 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger CCDC144C PF14915.4 MSTRG.21674.1_2 - 4.5e-83 278.7 60.8 4.5e-83 278.7 60.8 6.0 3 2 2 5 5 5 2 CCDC144C protein coiled-coil region DUF3496 PF12001.6 MSTRG.21674.1_2 - 8.5e-11 42.1 2.3 8.5e-11 42.1 2.3 9.9 6 2 6 13 13 13 1 Domain of unknown function (DUF3496) Glutaredoxin PF00462.22 MSTRG.13719.2_1 - 5.9e-13 48.7 1.4 6.1e-13 48.7 0.1 1.7 2 0 0 2 2 2 1 Glutaredoxin DUF836 PF05768.12 MSTRG.13719.2_1 - 0.0031 17.8 0.0 0.0056 16.9 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Tetraspannin PF00335.18 MSTRG.20275.1_3 - 8.9e-31 107.2 12.2 8.9e-31 107.2 12.2 2.4 3 0 0 3 3 3 1 Tetraspanin family O-FucT PF10250.7 MSTRG.564.2_3 - 3e-73 247.1 0.0 5e-73 246.4 0.0 1.3 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase A2M_comp PF07678.12 MSTRG.27256.3_1 - 1.7e-69 233.9 5.8 3.2e-69 233.0 5.8 1.5 1 0 0 1 1 1 1 A-macroglobulin complement component A2M PF00207.20 MSTRG.27256.3_1 - 6.3e-29 99.5 0.2 4.2e-28 96.9 0.0 2.5 2 0 0 2 2 2 1 Alpha-2-macroglobulin family A2M_N_2 PF07703.12 MSTRG.27256.3_1 - 3.1e-25 89.0 7.6 2.9e-24 85.9 0.5 4.1 4 0 0 4 4 4 1 Alpha-2-macroglobulin family N-terminal region A2M_recep PF07677.12 MSTRG.27256.3_1 - 5.7e-24 84.6 0.1 2.1e-23 82.8 0.1 2.1 1 0 0 1 1 1 1 A-macroglobulin receptor A2M_N PF01835.17 MSTRG.27256.3_1 - 3.2e-18 65.8 0.1 6.1e-17 61.7 0.0 2.8 2 0 0 2 2 2 1 MG2 domain Thiol-ester_cl PF10569.7 MSTRG.27256.3_1 - 6.9e-16 57.5 2.2 8.3e-16 57.3 0.9 1.9 2 0 0 2 2 2 1 Alpha-macro-globulin thiol-ester bond-forming region SVA PF05326.9 MSTRG.27256.3_1 - 6.1e-07 29.3 0.7 0.00032 20.5 0.0 3.2 3 0 0 3 3 3 2 Seminal vesicle autoantigen (SVA) THRAP3_BCLAF1 PF15440.4 MSTRG.15367.4_1 - 2.2e-81 274.7 92.0 3.2e-68 231.2 35.1 4.8 3 1 1 4 4 4 3 THRAP3/BCLAF1 family DNA_pol_phi PF04931.11 MSTRG.15367.4_1 - 8.4 4.2 21.5 13 3.7 21.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi Btz PF09405.8 MSTRG.15367.4_3 - 1.1e-05 25.6 6.3 1.1e-05 25.6 6.3 1.9 2 0 0 2 2 2 1 CASC3/Barentsz eIF4AIII binding Phos_pyr_kin PF08543.10 MSTRG.26343.1_2 - 4.7e-16 58.8 0.0 7.3e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.22 MSTRG.26343.1_2 - 7e-11 41.8 0.0 1.2e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase PHA_synth_III_E PF09712.8 MSTRG.19994.1_2 - 0.0043 16.1 3.5 0.0083 15.2 3.5 1.4 1 0 0 1 1 1 1 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) Latarcin PF10279.7 MSTRG.19994.1_2 - 0.0068 16.7 0.7 0.038 14.2 0.4 2.5 2 0 0 2 2 2 1 Latarcin precursor FUSC PF04632.10 MSTRG.19994.1_2 - 1.1 7.6 7.7 1.3 7.4 0.0 2.3 1 1 0 2 2 2 0 Fusaric acid resistance protein family DUF3450 PF11932.6 MSTRG.19994.1_2 - 1.8 7.7 12.1 0.53 9.4 1.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) UvrD_C PF13361.4 MSTRG.19994.1_2 - 3.3 6.9 7.9 1.2 8.3 3.1 2.1 1 1 1 2 2 2 0 UvrD-like helicase C-terminal domain Laminin_II PF06009.10 MSTRG.19994.1_2 - 6.4 6.7 7.9 14 5.6 0.1 3.7 3 2 1 4 4 4 0 Laminin Domain II Rdx PF10262.7 MSTRG.2490.5_1 - 1.6e-08 34.4 0.0 4e-08 33.2 0.0 1.7 1 1 0 1 1 1 1 Rdx family PH_9 PF15410.4 MSTRG.10203.2_1 - 1e-37 129.0 0.3 4.6e-37 126.9 0.0 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.27 MSTRG.10203.2_1 - 2.4e-12 47.2 0.0 4.1e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 PH domain A2M_comp PF07678.12 MSTRG.23715.2_1 - 4.7e-78 262.0 0.1 6.5e-78 261.5 0.1 1.2 1 0 0 1 1 1 1 A-macroglobulin complement component A2M_recep PF07677.12 MSTRG.23715.2_1 - 1.8e-25 89.4 0.1 3.8e-25 88.4 0.1 1.6 1 0 0 1 1 1 1 A-macroglobulin receptor Thiol-ester_cl PF10569.7 MSTRG.23715.2_1 - 1.7e-17 62.6 0.0 3.6e-17 61.6 0.0 1.6 1 0 0 1 1 1 1 Alpha-macro-globulin thiol-ester bond-forming region Kazal_2 PF07648.13 MSTRG.23715.2_1 - 2.5e-07 30.7 2.0 5.5e-07 29.5 2.0 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 MSTRG.23715.2_1 - 0.0011 18.8 8.0 0.0024 17.7 8.0 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Methyltransf_FA PF12248.6 MSTRG.23715.2_1 - 0.011 15.9 0.0 0.021 15.0 0.0 1.5 1 0 0 1 1 1 0 Farnesoic acid 0-methyl transferase SQHop_cyclase_N PF13249.4 MSTRG.23715.2_1 - 0.019 13.9 0.0 0.2 10.6 0.0 2.1 2 0 0 2 2 2 0 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.19 MSTRG.23715.2_1 - 0.41 10.3 2.4 2.1 8.0 0.0 3.2 3 0 0 3 3 3 0 Prenyltransferase and squalene oxidase repeat ATP-synt_8 PF00895.18 MSTRG.16156.1_1 - 4 7.9 5.0 1.2 9.5 0.8 2.1 2 0 0 2 2 2 0 ATP synthase protein 8 zf-B_box PF00643.22 MSTRG.22087.1_1 - 5.2e-09 36.0 0.7 5.2e-09 36.0 0.7 2.9 3 0 0 3 3 3 1 B-box zinc finger Ras PF00071.20 MSTRG.23073.1_1 - 1.7e-56 190.2 0.0 2.1e-56 189.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.23073.1_1 - 7e-23 81.0 0.0 9.9e-23 80.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.23073.1_1 - 3.8e-10 39.3 0.0 6.8e-10 38.5 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 MSTRG.23073.1_1 - 0.00038 19.9 0.0 0.00069 19.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 MSTRG.23073.1_1 - 0.087 12.0 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.8 MSTRG.23073.1_1 - 0.11 11.7 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit LRRNT PF01462.16 MSTRG.26235.1_3 - 0.47 10.0 8.0 0.62 9.6 2.2 2.2 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain DNA_methylase PF00145.15 MSTRG.19967.2_2 - 2e-13 50.3 0.0 2.5e-13 49.9 0.0 1.1 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase HELP PF03451.12 MSTRG.17702.2_3 - 4.1e-30 103.3 0.0 6.6e-30 102.6 0.0 1.3 1 0 0 1 1 1 1 HELP motif WD40 PF00400.30 MSTRG.17702.2_3 - 5.7e-11 42.7 3.2 3.3e-05 24.4 0.0 4.8 4 0 0 4 4 4 3 WD domain, G-beta repeat PKcGMP_CC PF16808.3 MSTRG.17702.2_3 - 0.0021 17.7 0.4 0.0055 16.4 0.4 1.7 1 0 0 1 1 1 1 Coiled-coil N-terminus of cGMP-dependent protein kinase SlyX PF04102.10 MSTRG.17702.2_3 - 0.092 13.2 1.2 0.2 12.2 1.2 1.5 1 0 0 1 1 1 0 SlyX Fib_alpha PF08702.8 MSTRG.17702.2_3 - 0.12 12.5 0.3 0.19 11.8 0.3 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family TPR_1 PF00515.26 MSTRG.10713.1_3 - 0.069 12.9 0.1 0.069 12.9 0.1 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.10713.1_3 - 0.35 11.0 6.3 13 6.1 0.1 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat NUDIX PF00293.26 MSTRG.3662.2_2 - 9.5e-20 70.8 0.0 1.7e-19 70.0 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain FAM217 PF15344.4 MSTRG.6351.2_1 - 1.4e-06 28.3 0.1 2.9e-06 27.3 0.1 1.5 1 0 0 1 1 1 1 FAM217 family FAM217 PF15344.4 MSTRG.6351.2_2 - 2.8e-28 99.3 0.1 2.8e-28 99.3 0.1 1.8 2 0 0 2 2 2 1 FAM217 family DUF4125 PF13526.4 MSTRG.6351.2_2 - 8.6e-05 22.1 0.0 0.00013 21.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4125) BTB PF00651.29 MSTRG.10259.1_2 - 4.6e-21 75.0 0.5 1e-20 73.9 0.5 1.6 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_4 PF13894.4 MSTRG.10259.1_2 - 1.8e-07 31.2 19.1 0.0078 16.8 3.6 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.4 MSTRG.10259.1_2 - 5.1e-06 26.6 5.7 0.00087 19.5 0.2 4.5 5 0 0 5 5 5 2 Zinc-finger double domain DUF2487 PF10673.7 MSTRG.10259.1_2 - 0.11 12.4 0.1 2.3 8.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2487) zf-C2H2 PF00096.24 MSTRG.10259.1_2 - 3.3 8.2 19.9 0.53 10.7 0.4 3.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-Di19 PF05605.10 MSTRG.10259.1_2 - 7 6.9 9.2 19 5.5 4.7 3.0 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding TIM21 PF08294.9 MSTRG.352.1_1 - 3.7e-48 163.0 0.0 4.8e-48 162.6 0.0 1.1 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.8 MSTRG.352.1_1 - 2.6e-05 23.8 0.0 5.3e-05 22.8 0.0 1.4 1 1 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 Arf PF00025.19 MSTRG.14068.1_3 - 4.7e-78 260.5 0.1 6.1e-78 260.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 MSTRG.14068.1_3 - 3.5e-14 52.5 0.0 4.8e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.11 MSTRG.14068.1_3 - 1.5e-13 50.9 0.0 2.3e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 MSTRG.14068.1_3 - 2.6e-12 46.5 0.0 3.3e-12 46.2 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.18 MSTRG.14068.1_3 - 7.4e-11 41.7 1.1 2.8e-07 29.9 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 MSTRG.14068.1_3 - 3e-10 39.7 0.0 4e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 MSTRG.14068.1_3 - 7.8e-05 22.6 0.0 0.00012 22.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.16 MSTRG.14068.1_3 - 0.022 14.0 0.5 0.066 12.4 0.1 1.7 2 0 0 2 2 2 0 6-phosphofructo-2-kinase MutS_V PF00488.19 MSTRG.7721.1_2 - 4.6e-71 238.7 0.0 7.5e-71 238.0 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.16 MSTRG.7721.1_2 - 4.4e-34 118.2 0.0 4.4e-34 118.2 0.0 1.8 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.18 MSTRG.7721.1_2 - 4.8e-34 116.9 0.1 9.4e-34 115.9 0.1 1.5 1 0 0 1 1 1 1 MutS domain I PWWP PF00855.15 MSTRG.7721.1_2 - 1.8e-17 63.4 0.0 6.3e-17 61.7 0.0 1.9 1 0 0 1 1 1 1 PWWP domain MutS_IV PF05190.16 MSTRG.7721.1_2 - 3.2e-15 56.1 0.1 7.8e-15 54.9 0.1 1.7 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.15 MSTRG.7721.1_2 - 1e-11 45.1 0.0 3.9e-11 43.3 0.0 2.0 1 1 0 1 1 1 1 MutS domain II SDA1 PF05285.10 MSTRG.7721.1_2 - 5.4 6.2 17.5 9.2 5.5 17.5 1.2 1 0 0 1 1 1 0 SDA1 Asp-B-Hydro_N PF05279.9 MSTRG.7721.1_2 - 5.5 6.8 18.8 12 5.7 18.8 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Ribosomal_S4 PF00163.17 MSTRG.12123.1_1 - 2e-08 34.9 2.7 3.7e-08 34.1 2.7 1.4 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.23 MSTRG.12123.1_1 - 9.2e-08 31.5 0.0 1.6e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 S4 domain Serpin PF00079.18 MSTRG.25669.1_2 - 3.9e-112 375.1 4.8 4.5e-112 374.9 4.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Imm45 PF15572.4 MSTRG.25669.1_2 - 0.12 12.6 0.0 0.31 11.3 0.0 1.6 1 0 0 1 1 1 0 Immunity protein 45 HEAT PF02985.20 MSTRG.26541.1_2 - 0.099 12.8 0.2 25 5.3 0.0 4.0 4 0 0 4 4 4 0 HEAT repeat Carn_acyltransf PF00755.18 MSTRG.11845.4_1 - 9e-60 202.8 0.0 1.1e-59 202.4 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase DUF2716 PF10898.6 MSTRG.11845.4_1 - 0.19 11.9 0.0 0.38 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2716) Fasciclin PF02469.20 MSTRG.25779.1_2 - 1.2e-100 332.5 0.0 3.2e-29 101.6 0.0 4.2 4 0 0 4 4 4 4 Fasciclin domain DUF3915 PF13054.4 MSTRG.746.1_1 - 0.02 14.7 7.1 0.036 13.9 7.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF3915 PF13054.4 MSTRG.746.1_2 - 0.76 9.6 10.2 2.2 8.2 10.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) PTEN_C2 PF10409.7 MSTRG.746.1_3 - 1.6e-31 108.7 0.0 2.5e-31 108.1 0.0 1.3 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein Y_phosphatase PF00102.25 MSTRG.746.1_3 - 0.011 15.1 0.0 0.042 13.3 0.0 1.8 2 0 0 2 2 2 0 Protein-tyrosine phosphatase DUF3915 PF13054.4 MSTRG.746.1_3 - 2.7 7.9 10.3 5.7 6.8 10.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) CH PF00307.29 MSTRG.21385.3_3 - 1.2e-08 35.0 0.1 1.8e-08 34.4 0.1 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain Imm17 PF15562.4 MSTRG.14691.4_2 - 8.5 6.2 13.5 34 4.3 0.1 5.2 5 0 0 5 5 5 0 Immunity protein 17 CRAM_rpt PF07016.9 MSTRG.14691.4_3 - 5.5e-05 22.7 22.6 0.45 10.2 1.8 9.2 9 2 1 10 10 10 5 Cysteine-rich acidic integral membrane protein precursor UBA PF00627.29 MSTRG.25059.1_1 - 5.4e-08 32.5 0.5 0.014 15.1 0.1 3.4 3 0 0 3 3 3 3 UBA/TS-N domain WIYLD PF10440.7 MSTRG.25059.1_1 - 0.0069 16.0 0.0 2.1 8.1 0.0 2.6 2 1 0 2 2 2 2 Ubiquitin-binding WIYLD domain Apelin PF15360.4 MSTRG.15921.1_1 - 1.4e-23 83.0 9.6 1.4e-23 83.0 9.6 2.6 2 0 0 2 2 2 1 APJ endogenous ligand UcrQ PF02939.14 MSTRG.7365.1_1 - 1.4e-31 108.1 0.7 1.9e-31 107.7 0.7 1.2 1 0 0 1 1 1 1 UcrQ family Cyt_b-c1_8 PF10890.6 MSTRG.7365.1_1 - 0.12 12.7 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 Cytochrome b-c1 complex subunit 8 Pkinase PF00069.23 MSTRG.25686.1_1 - 1.1e-70 237.9 0.2 1.4e-70 237.5 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.25686.1_1 - 7.9e-20 71.1 0.0 1.2e-19 70.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 MSTRG.25686.1_1 - 1.2e-06 28.5 0.0 3.3e-05 23.8 0.1 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.12 MSTRG.25686.1_1 - 0.0023 17.2 0.1 0.0038 16.5 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.18 MSTRG.25686.1_1 - 0.028 13.9 0.2 0.053 13.0 0.2 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase PID PF00640.21 MSTRG.3099.1_3 - 1.7e-18 66.9 0.0 2.6e-18 66.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 MSTRG.3099.1_3 - 3.8e-06 27.0 0.0 5.7e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID_2 PF14719.4 MSTRG.3099.1_3 - 5.3e-05 23.0 0.0 7.5e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) HAUS-augmin3 PF14932.4 MSTRG.25929.1_2 - 2.6e-68 230.2 13.1 2.6e-68 230.2 13.1 2.5 2 0 0 2 2 2 1 HAUS augmin-like complex subunit 3 CC2-LZ PF16516.3 MSTRG.25929.1_2 - 0.61 10.3 14.6 0.054 13.7 1.2 3.4 3 0 0 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Jnk-SapK_ap_N PF09744.7 MSTRG.25929.1_2 - 5.4 7.1 23.4 0.11 12.6 4.5 3.3 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 zf-DHHC PF01529.18 MSTRG.7606.2_1 - 4.4e-37 127.0 7.7 4.4e-37 127.0 7.7 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase Imm17 PF15562.4 MSTRG.7606.2_1 - 0.026 14.3 4.5 0.4 10.5 0.3 3.0 3 0 0 3 3 3 0 Immunity protein 17 Barwin PF00967.15 MSTRG.17314.1_1 - 0.14 11.9 6.1 0.48 10.2 3.3 2.2 1 1 1 2 2 2 0 Barwin family RFX_DNA_binding PF02257.13 MSTRG.17314.1_3 - 1.2e-26 93.0 0.0 2e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.14 MSTRG.17314.1_3 - 7e-06 26.3 0.1 1.2e-05 25.6 0.1 1.3 1 0 0 1 1 1 1 Poxvirus D5 protein-like Cdc6_C PF09079.9 MSTRG.17314.1_3 - 0.0081 16.0 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain PIP5K PF01504.16 MSTRG.23674.1_2 - 1.3e-94 316.3 0.0 2e-94 315.8 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase SH3_9 PF14604.4 MSTRG.16636.1_2 - 1e-39 134.0 0.2 2.1e-13 49.7 0.1 3.5 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.26 MSTRG.16636.1_2 - 5.4e-37 125.0 0.0 4.8e-11 41.9 0.0 3.5 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.15 MSTRG.16636.1_2 - 5.4e-29 99.5 0.2 4.8e-11 42.1 0.0 3.4 3 0 0 3 3 3 3 Variant SH3 domain Sorb PF02208.14 MSTRG.16636.1_2 - 1.4e-16 59.7 0.0 3.2e-16 58.6 0.0 1.6 1 0 0 1 1 1 1 Sorbin homologous domain FAP PF07174.9 MSTRG.16636.1_3 - 0.53 9.6 4.1 0.85 8.9 4.1 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) PLAC8 PF04749.15 MSTRG.6629.1_2 - 6.4e-17 62.2 19.3 9.3e-17 61.7 19.3 1.2 1 0 0 1 1 1 1 PLAC8 family COG5 PF10392.7 MSTRG.28074.1_3 - 0.087 12.9 1.0 0.15 12.1 1.0 1.3 1 0 0 1 1 1 0 Golgi transport complex subunit 5 V-set PF07686.15 MSTRG.18779.1_3 - 2.4e-13 50.1 0.0 6e-13 48.8 0.0 1.6 2 0 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.14 MSTRG.18779.1_3 - 8.2e-05 22.5 0.0 0.00017 21.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.18779.1_3 - 8.7e-05 22.9 0.0 0.00018 21.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 MSTRG.18779.1_3 - 0.00075 19.5 0.0 0.0018 18.3 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.18779.1_3 - 0.0078 16.4 0.0 0.043 14.0 0.0 2.2 1 1 0 1 1 1 1 Immunoglobulin domain La PF05383.15 MSTRG.18779.1_3 - 0.049 13.6 0.0 0.17 11.8 0.0 1.8 2 0 0 2 2 2 0 La domain Glyco_tranf_2_3 PF13641.4 MSTRG.17174.1_3 - 1e-16 61.5 0.1 1.8e-12 47.6 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Chitin_synth_2 PF03142.13 MSTRG.17174.1_3 - 8.5e-14 50.9 4.1 1e-08 34.2 2.8 3.3 2 1 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.4 MSTRG.17174.1_3 - 4.3e-07 29.9 9.9 4.3e-07 29.9 9.9 2.2 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.24 MSTRG.17174.1_3 - 4.6e-07 29.7 0.0 0.00028 20.6 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 2 FH2 PF02181.21 MSTRG.1136.3_3 - 1.7e-92 310.3 13.0 1.7e-92 310.3 13.0 2.9 2 1 1 3 3 3 1 Formin Homology 2 Domain Drf_FH3 PF06367.14 MSTRG.1136.3_3 - 4.3e-41 140.6 15.1 1.1e-40 139.2 15.1 1.8 1 0 0 1 1 1 1 Diaphanous FH3 Domain Drf_GBD PF06371.11 MSTRG.1136.3_3 - 1.1e-27 96.7 7.3 2.1e-13 50.1 0.0 3.8 3 1 0 3 3 3 2 Diaphanous GTPase-binding Domain COG2 PF06148.9 MSTRG.1136.3_3 - 0.0083 16.1 6.1 0.0083 16.1 6.1 2.2 2 1 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Tropomyosin_1 PF12718.5 MSTRG.1136.3_3 - 0.18 11.8 15.2 0.64 10.0 15.2 1.9 1 0 0 1 1 1 0 Tropomyosin like CALCOCO1 PF07888.9 MSTRG.1136.3_3 - 0.95 7.8 11.5 2.1 6.7 11.5 1.5 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF4407 PF14362.4 MSTRG.1136.3_3 - 1.5 8.0 6.9 2.2 7.4 6.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CLTH PF10607.7 MSTRG.1136.3_3 - 1.7 8.4 5.5 1.3 8.8 2.4 2.4 2 1 0 2 2 2 0 CTLH/CRA C-terminal to LisH motif domain DUF1664 PF07889.10 MSTRG.1136.3_3 - 1.9 8.3 9.2 4.9 7.0 8.1 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF1342 PF07072.9 MSTRG.1136.3_3 - 2.4 7.7 7.5 6.5 6.3 7.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1342) DUF342 PF03961.11 MSTRG.1136.3_3 - 2.5 6.4 8.5 5.6 5.3 8.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF342) BST2 PF16716.3 MSTRG.1136.3_3 - 7.6 7.0 14.7 5.4 7.5 2.0 2.9 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 FlgN PF05130.10 MSTRG.1136.3_3 - 10 6.5 14.5 17 5.8 5.7 2.9 1 1 1 2 2 2 0 FlgN protein Myosin_head PF00063.19 MSTRG.1426.6_1 - 1.6e-266 885.8 3.9 2.1e-266 885.4 3.9 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.11 MSTRG.1426.6_1 - 1.9e-39 135.1 6.1 3.1e-39 134.4 0.5 2.7 3 0 0 3 3 3 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.25 MSTRG.1426.6_1 - 1.3e-06 27.6 22.7 0.0021 17.5 0.1 5.2 5 0 0 5 5 5 3 IQ calmodulin-binding motif AAA_16 PF13191.4 MSTRG.1426.6_1 - 0.0038 17.5 0.1 0.016 15.5 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.4 MSTRG.1426.6_1 - 0.023 14.8 0.0 0.1 12.7 0.0 2.1 1 0 0 1 1 1 0 AAA domain Evr1_Alr PF04777.11 MSTRG.1426.6_1 - 0.038 14.4 0.3 1.5 9.2 0.1 3.1 2 1 0 2 2 2 0 Erv1 / Alr family Yqai PF09466.8 MSTRG.1426.6_1 - 0.092 12.9 0.2 0.31 11.3 0.2 1.9 1 1 0 1 1 1 0 Hypothetical protein Yqai Hpr_kinase_C PF07475.10 MSTRG.1426.6_1 - 0.22 10.9 0.8 2.9 7.2 0.0 2.4 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain CENP-B_N PF04218.11 MSTRG.15186.2_1 - 1.3e-06 27.8 0.5 2.6e-06 26.8 0.5 1.5 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_23 PF13384.4 MSTRG.15186.2_1 - 0.00074 19.1 0.1 0.0014 18.3 0.1 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.4 MSTRG.15186.2_1 - 0.018 15.0 0.0 0.034 14.1 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_29 PF13551.4 MSTRG.15186.2_1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn helix Activator_LAG-3 PF11498.6 MSTRG.6542.3_1 - 0.7 8.7 37.1 1.2 7.9 37.1 1.3 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TFIIA PF03153.11 MSTRG.6542.3_1 - 2.5 7.9 24.9 4 7.2 24.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FOXP-CC PF16159.3 MSTRG.6542.3_2 - 6e-34 116.4 2.2 1.2e-33 115.4 2.2 1.6 1 0 0 1 1 1 1 FOXP coiled-coil domain Forkhead PF00250.16 MSTRG.6542.3_2 - 1.7e-27 95.4 0.3 3.6e-27 94.4 0.3 1.6 1 0 0 1 1 1 1 Forkhead domain SSF PF00474.15 MSTRG.26406.1_1 - 2e-17 63.0 12.4 3.2e-17 62.4 12.4 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family ODR4-like PF14778.4 MSTRG.7042.3_2 - 4.9e-12 45.3 0.0 6.5e-12 44.9 0.0 1.2 1 0 0 1 1 1 1 Olfactory receptor 4-like T4SS_CagC PF16943.3 MSTRG.7042.3_2 - 0.026 14.6 0.1 0.042 13.9 0.1 1.3 1 0 0 1 1 1 0 Cag pathogenicity island, type IV secretory system Cas_Csa5 PF09702.8 MSTRG.7042.3_2 - 0.09 12.9 0.3 0.13 12.4 0.3 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csa5) DUF349 PF03993.10 MSTRG.7042.3_2 - 0.1 12.8 0.2 0.17 12.1 0.2 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) PP1_inhibitor PF05361.10 MSTRG.23401.1_2 - 6.8e-30 103.8 3.5 9.5e-30 103.3 3.5 1.2 1 0 0 1 1 1 1 PKC-activated protein phosphatase-1 inhibitor RhoGAP PF00620.25 MSTRG.12731.2_3 - 7.5e-51 171.8 0.1 1.3e-50 171.0 0.1 1.4 1 0 0 1 1 1 1 RhoGAP domain PH_9 PF15410.4 MSTRG.12731.2_3 - 1.9e-11 44.2 0.0 4.1e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 MSTRG.12731.2_3 - 3.9e-09 36.8 0.0 8.4e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 MSTRG.12731.2_3 - 0.00095 19.4 0.0 0.0027 18.0 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain Apc13p PF05839.9 MSTRG.12731.2_3 - 1.9 8.6 0.0 1.9 8.6 0.0 3.1 4 0 0 4 4 4 0 Apc13p protein Lectin_C PF00059.19 MSTRG.28059.1_2 - 1e-15 58.2 0.0 2.2e-15 57.2 0.0 1.6 1 1 0 1 1 1 1 Lectin C-type domain MHC_I PF00129.16 MSTRG.19712.2_2 - 6.5e-35 120.2 3.2 9e-35 119.7 3.2 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 MSTRG.19712.2_2 - 4.9e-09 36.4 0.0 1.1e-08 35.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain TMEM154 PF15102.4 MSTRG.19712.2_2 - 0.00038 20.3 0.0 0.00078 19.2 0.0 1.5 1 0 0 1 1 1 1 TMEM154 protein family MHC_I_3 PF16497.3 MSTRG.19712.2_2 - 0.034 13.5 0.6 0.059 12.7 0.6 1.4 1 0 0 1 1 1 0 MHC-I family domain SecG PF03840.12 MSTRG.19712.2_2 - 0.041 13.8 0.0 0.085 12.8 0.0 1.5 1 0 0 1 1 1 0 Preprotein translocase SecG subunit G_glu_transpept PF01019.19 MSTRG.4214.1_3 - 2.2e-88 297.2 0.0 2.6e-88 296.9 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase MAM PF00629.21 MSTRG.15625.4_2 - 9.3e-27 93.7 0.0 3.3e-26 91.9 0.0 2.0 2 0 0 2 2 2 1 MAM domain, meprin/A5/mu fn3 PF00041.19 MSTRG.15625.4_2 - 2.2e-25 88.7 6.7 1.2e-09 38.2 0.0 5.3 5 0 0 5 5 5 3 Fibronectin type III domain ig PF00047.23 MSTRG.15625.4_2 - 1.2e-08 34.9 0.1 1.1e-07 31.7 0.0 2.7 3 0 0 3 3 3 1 Immunoglobulin domain I-set PF07679.14 MSTRG.15625.4_2 - 3.7e-06 26.8 0.0 1.1e-05 25.3 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.15625.4_2 - 5.6e-06 26.5 0.6 4e-05 23.7 0.0 2.6 2 1 1 3 3 3 1 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.15625.4_2 - 9.2e-06 26.1 0.0 3.1e-05 24.4 0.0 2.0 1 0 0 1 1 1 1 Immunoglobulin domain Pur_ac_phosph_N PF16656.3 MSTRG.15625.4_2 - 0.0017 18.8 2.7 0.13 12.7 0.3 3.6 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.3 MSTRG.15625.4_2 - 0.0054 16.7 0.1 9.7 6.3 0.0 3.8 3 1 0 3 3 3 1 Fibronectin type III domain Med21 PF11221.6 MSTRG.20616.2_2 - 1.5e-18 67.3 3.7 3.4e-18 66.1 3.7 1.5 1 1 0 1 1 1 1 Subunit 21 of Mediator complex DUF2730 PF10805.6 MSTRG.20616.2_2 - 0.044 13.7 0.3 0.078 12.9 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) DUF4559 PF15112.4 MSTRG.20616.2_3 - 0.05 13.2 0.5 0.061 12.9 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) 53-BP1_Tudor PF09038.8 MSTRG.5925.2_3 - 1.2e-68 228.6 0.0 8.4e-68 225.8 0.1 2.3 2 0 0 2 2 2 1 Tumour suppressor p53-binding protein-1 Tudor BRCT_2 PF16589.3 MSTRG.5925.2_3 - 4.6e-06 26.8 0.0 0.0013 18.9 0.0 3.2 3 0 0 3 3 3 1 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.3 MSTRG.5925.2_3 - 0.0007 19.3 0.0 0.0016 18.2 0.0 1.6 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain DUF4537 PF15057.4 MSTRG.5925.2_3 - 0.0013 18.6 0.0 0.003 17.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) BRCT PF00533.24 MSTRG.5925.2_3 - 0.005 17.1 0.0 0.53 10.6 0.0 2.7 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Occludin_ELL PF07303.11 MSTRG.10663.1_1 - 8.9e-28 96.8 9.2 1.4e-27 96.2 9.2 1.3 1 0 0 1 1 1 1 Occludin homology domain MARVEL PF01284.21 MSTRG.10663.1_1 - 1.1e-14 54.6 10.6 1.8e-14 53.9 10.6 1.4 1 0 0 1 1 1 1 Membrane-associating domain Keratin_2_head PF16208.3 MSTRG.10663.1_1 - 0.0044 17.1 15.9 0.0096 16.0 15.9 1.5 1 0 0 1 1 1 1 Keratin type II head PRP1_N PF06424.10 MSTRG.10663.1_1 - 0.95 9.8 5.7 1.7 9.0 5.7 1.3 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal PRKG1_interact PF15898.3 MSTRG.10663.1_1 - 2.5 8.9 4.8 26 5.7 4.0 2.2 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain SecE PF00584.18 MSTRG.10663.1_1 - 6.1 6.7 9.0 0.15 11.8 0.3 2.4 2 0 0 2 2 2 0 SecE/Sec61-gamma subunits of protein translocation complex SNF PF00209.16 MSTRG.21205.1_2 - 1.6e-60 205.2 9.0 2e-60 204.8 9.0 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Vps55 PF04133.12 MSTRG.21205.1_2 - 0.0035 17.1 0.2 0.008 16.0 0.2 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting 55 SNF PF00209.16 MSTRG.21205.1_3 - 7.7e-85 285.4 1.1 1e-84 285.0 1.1 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family CK1gamma_C PF12605.6 MSTRG.17597.1_3 - 6.4e-31 107.3 5.0 1.3e-30 106.3 5.0 1.5 1 0 0 1 1 1 1 Casein kinase 1 gamma C terminal Pkinase PF00069.23 MSTRG.17597.1_3 - 3.4e-25 88.8 0.0 5.1e-25 88.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.17597.1_3 - 1.8e-12 47.0 0.0 2.6e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DEP PF00610.19 MSTRG.5203.1_1 - 7.5e-41 137.9 0.0 2.4e-21 75.5 0.0 2.4 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PDZ PF00595.22 MSTRG.5203.1_1 - 5.7e-06 26.5 0.0 9.4e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.5203.1_1 - 0.0019 18.3 0.0 0.0035 17.5 0.0 1.4 1 0 0 1 1 1 1 PDZ domain UPF1_Zn_bind PF09416.8 MSTRG.5203.1_1 - 0.16 11.8 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 RNA helicase (UPF2 interacting domain) Dak1 PF02733.15 MSTRG.24521.7_2 - 2.3e-109 364.9 1.3 3.1e-109 364.4 1.3 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.15 MSTRG.24521.7_2 - 5.3e-43 146.8 5.6 5.3e-43 146.8 5.6 1.7 2 0 0 2 2 2 1 DAK2 domain Rho_GDI PF02115.15 MSTRG.6415.1_3 - 2e-73 246.1 0.2 2.8e-73 245.6 0.2 1.1 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor DUF2464 PF10240.7 MSTRG.2913.1_3 - 1.4e-76 257.2 0.0 1.7e-76 256.9 0.0 1.1 1 0 0 1 1 1 1 Multivesicular body subunit 12 DUF4024 PF13216.4 MSTRG.7237.1_3 - 0.02 14.7 1.0 0.043 13.6 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4024) DUF4042 PF13251.4 MSTRG.7247.2_1 - 1.5e-71 239.8 1.0 2.4e-70 235.8 0.1 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4042) HEAT_2 PF13646.4 MSTRG.7247.2_1 - 5.3e-13 49.0 9.8 0.00016 21.8 0.2 6.7 5 2 2 7 7 7 4 HEAT repeats HEAT_EZ PF13513.4 MSTRG.7247.2_1 - 1.6e-09 37.9 13.4 0.054 13.8 0.1 6.4 5 0 0 5 5 5 4 HEAT-like repeat HEAT PF02985.20 MSTRG.7247.2_1 - 2.9e-09 36.2 17.9 0.0052 16.8 0.0 8.6 11 0 0 11 11 11 2 HEAT repeat Cnd1 PF12717.5 MSTRG.7247.2_1 - 0.0024 17.7 3.2 1.1 9.1 0.6 3.8 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.7 MSTRG.7247.2_1 - 0.004 17.2 3.7 0.3 11.1 0.0 3.6 4 0 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Pkinase PF00069.23 MSTRG.8997.2_2 - 5.1e-73 245.6 0.0 6.6e-73 245.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.8997.2_2 - 4.9e-47 160.3 0.0 6.9e-47 159.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 MSTRG.8997.2_2 - 4.7e-25 87.6 0.1 9e-25 86.7 0.1 1.5 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 MSTRG.8997.2_2 - 2e-07 30.5 0.1 0.00024 20.4 0.1 2.2 1 1 1 2 2 2 2 Kinase-like Kdo PF06293.12 MSTRG.8997.2_2 - 0.0079 15.4 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 MSTRG.8997.2_2 - 0.0088 15.8 0.0 0.25 11.1 0.2 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family MRI PF15325.4 MSTRG.8997.2_2 - 0.49 11.5 4.5 0.21 12.7 0.3 2.4 2 0 0 2 2 2 0 Modulator of retrovirus infection Complex1_LYR PF05347.13 MSTRG.26303.1_2 - 6e-06 26.1 0.2 1e-05 25.4 0.2 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Edc3_linker PF16598.3 MSTRG.18328.1_1 - 1.4 9.5 4.9 2.6 8.7 4.9 1.4 1 0 0 1 1 1 0 Linker region of enhancer of mRNA-decapping protein 3 MARVEL PF01284.21 MSTRG.18328.1_3 - 1.4e-10 41.3 17.1 5e-10 39.4 17.1 2.0 1 1 0 1 1 1 1 Membrane-associating domain DUF438 PF04282.11 MSTRG.28114.1_2 - 0.005 16.6 0.2 0.0091 15.8 0.2 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF438) DGCR6 PF07324.9 MSTRG.28114.1_2 - 0.029 13.9 3.4 0.04 13.4 2.6 1.6 1 1 0 1 1 1 0 DiGeorge syndrome critical region 6 (DGCR6) protein Dynamin_N PF00350.21 MSTRG.28114.1_3 - 7.2e-06 26.0 0.0 1.1e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Dynamin family RHD3 PF05879.10 MSTRG.28114.1_3 - 0.00015 20.0 0.0 0.00018 19.7 0.0 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.17 MSTRG.28114.1_3 - 0.074 12.2 0.1 0.11 11.7 0.1 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain MPC PF03650.11 MSTRG.23221.2_3 - 1.4e-32 112.0 0.0 2e-32 111.4 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) Lipocalin PF00061.21 MSTRG.9834.1_1 - 1.1e-22 80.7 0.3 1.2e-22 80.5 0.3 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 MSTRG.9834.1_1 - 1e-07 31.8 0.1 1.3e-07 31.4 0.1 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family UDPGT PF00201.16 MSTRG.14838.2_2 - 4.5e-109 365.4 0.7 5.2e-109 365.2 0.7 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 MSTRG.14838.2_2 - 4.9e-06 26.5 0.0 7e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain DUF4312 PF14189.4 MSTRG.14838.2_2 - 0.047 13.6 0.0 0.081 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4312) Pro_3_hydrox_C PF05373.9 MSTRG.14838.2_2 - 0.12 12.3 0.1 0.19 11.7 0.1 1.2 1 0 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal Lipocalin_7 PF14651.4 MSTRG.7484.1_3 - 4.4e-25 88.0 0.9 5.2e-25 87.7 0.9 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family zf-MIZ PF02891.18 MSTRG.16766.2_2 - 6.7e-23 80.0 4.4 6.7e-23 80.0 4.4 2.6 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-Nse PF11789.6 MSTRG.16766.2_2 - 9.5e-06 25.2 0.9 9.5e-06 25.2 0.9 2.2 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit MHC_I PF00129.16 MSTRG.16139.2_3 - 4.4e-31 107.7 3.3 5.9e-31 107.3 3.3 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 MSTRG.16139.2_3 - 1.7e-09 37.9 0.0 5.4e-09 36.3 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.3 MSTRG.16139.2_3 - 0.0038 16.6 0.0 0.0064 15.8 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain Ig_3 PF13927.4 MSTRG.16139.2_3 - 0.0057 17.1 0.2 0.043 14.3 0.0 2.6 3 0 0 3 3 3 1 Immunoglobulin domain EphA2_TM PF14575.4 MSTRG.16139.2_3 - 0.024 15.3 0.1 0.058 14.1 0.1 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Marek_A PF02124.13 MSTRG.16139.2_3 - 0.029 14.1 0.1 0.043 13.5 0.1 1.2 1 0 0 1 1 1 0 Marek's disease glycoprotein A ig PF00047.23 MSTRG.16139.2_3 - 0.037 14.0 0.0 0.18 11.9 0.0 2.2 2 0 0 2 2 2 0 Immunoglobulin domain TMEM154 PF15102.4 MSTRG.16139.2_3 - 0.039 13.7 0.6 0.082 12.7 0.6 1.4 1 0 0 1 1 1 0 TMEM154 protein family DUF1191 PF06697.10 MSTRG.16139.2_3 - 0.042 12.9 0.4 0.065 12.3 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) DUF4448 PF14610.4 MSTRG.16139.2_3 - 0.066 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF4083 PF13314.4 MSTRG.16139.2_3 - 0.067 13.0 1.3 0.12 12.2 1.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) ECSCR PF15820.3 MSTRG.16139.2_3 - 0.068 12.9 0.4 0.13 12.0 0.4 1.4 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator DUF912 PF06024.10 MSTRG.16139.2_3 - 0.079 13.1 0.3 0.18 12.0 0.3 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF1510 PF07423.9 MSTRG.16139.2_3 - 0.11 11.8 0.2 0.17 11.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF3357 PF11837.6 MSTRG.16139.2_3 - 0.14 12.5 0.2 0.26 11.6 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) UPF0258 PF06789.10 MSTRG.16139.2_3 - 0.24 11.5 5.0 0.43 10.6 5.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0258) VWD PF00094.23 MSTRG.25035.1_3 - 7.5e-117 386.9 30.2 9.1e-31 107.1 2.5 4.6 4 0 0 4 4 4 4 von Willebrand factor type D domain C8 PF08742.9 MSTRG.25035.1_3 - 1.2e-59 198.4 64.5 8e-19 67.7 12.9 10.4 10 1 1 11 11 11 4 C8 domain TIL PF01826.15 MSTRG.25035.1_3 - 2.4e-14 53.2 67.9 4.7e-07 29.8 11.5 18.7 13 3 5 19 19 19 4 Trypsin Inhibitor like cysteine rich domain VWC PF00093.16 MSTRG.25035.1_3 - 2.6e-05 24.3 30.6 0.00018 21.6 15.2 19.1 12 7 6 18 18 18 6 von Willebrand factor type C domain Nucleoside_tran PF01733.16 MSTRG.19307.1_1 - 5.7e-38 130.9 0.9 7e-38 130.6 0.9 1.1 1 0 0 1 1 1 1 Nucleoside transporter PI3K_P85_iSH2 PF16454.3 MSTRG.12699.1_3 - 1.1e-52 177.7 11.7 1.7e-52 177.1 11.7 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain SH2 PF00017.22 MSTRG.12699.1_3 - 4.6e-39 132.2 0.0 6.9e-20 70.8 0.0 2.5 2 0 0 2 2 2 2 SH2 domain Mod_r PF07200.11 MSTRG.12699.1_3 - 0.26 11.3 9.7 0.59 10.1 3.1 2.2 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Exonuc_VII_L PF02601.13 MSTRG.12699.1_3 - 0.31 10.4 1.9 0.47 9.8 1.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit BRE1 PF08647.9 MSTRG.12699.1_3 - 0.38 10.7 5.1 8.5 6.4 3.9 2.4 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase ING PF12998.5 MSTRG.12699.1_3 - 2.3 8.7 5.7 8.7 6.8 0.6 2.4 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding GPCR_chapero_1 PF11904.6 MSTRG.3076.1_3 - 1.2e-98 330.2 0.1 2.1e-98 329.4 0.1 1.4 1 0 0 1 1 1 1 GPCR-chaperone Ank_2 PF12796.5 MSTRG.3076.1_3 - 5.5e-11 42.8 0.0 1.4e-10 41.5 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.3076.1_3 - 2.7e-09 37.0 0.0 3e-08 33.7 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.4 MSTRG.3076.1_3 - 1.6e-08 34.8 0.0 4.6e-08 33.3 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.3076.1_3 - 3.5e-07 29.9 0.0 0.00054 20.1 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.28 MSTRG.3076.1_3 - 6.8e-07 29.3 0.0 1.4e-05 25.2 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeat UIM PF02809.18 MSTRG.3076.1_3 - 6.6 6.8 8.7 43 4.2 0.0 3.6 3 0 0 3 3 3 0 Ubiquitin interaction motif PAPA-1 PF04795.10 MSTRG.25844.1_2 - 4.1e-12 46.6 9.8 1.7e-11 44.6 9.8 2.2 1 0 0 1 1 1 1 PAPA-1-like conserved region zf-HIT PF04438.14 MSTRG.25844.1_2 - 3e-08 33.3 6.8 6.2e-08 32.3 6.8 1.5 1 0 0 1 1 1 1 HIT zinc finger APC_u9 PF16633.3 MSTRG.25844.1_2 - 0.031 15.2 3.0 0.064 14.2 3.0 1.5 1 0 0 1 1 1 0 Unstructured region on APC between 1st two creatine-rich regions DUF4666 PF15697.3 MSTRG.25844.1_2 - 1.7 9.3 6.3 0.82 10.2 3.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4666) Ras PF00071.20 MSTRG.11038.1_2 - 8.3e-28 96.9 0.1 1.2e-27 96.3 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.11038.1_2 - 2.9e-05 24.2 0.1 5.2e-05 23.3 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DUF3963 PF13124.4 MSTRG.11038.1_2 - 0.022 14.6 0.5 0.036 13.9 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3963) V-set PF07686.15 MSTRG.8263.1_2 - 0.09 12.8 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin V-set domain Ig_2 PF13895.4 MSTRG.8263.1_2 - 0.13 12.5 0.1 0.2 11.9 0.1 1.3 1 0 0 1 1 1 0 Immunoglobulin domain Myosin_head PF00063.19 MSTRG.5044.1_3 - 1.5e-234 780.1 4.9 1.7e-234 779.9 4.9 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.11 MSTRG.5044.1_3 - 1.2e-42 145.6 0.0 2.2e-42 144.7 0.0 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding AAA_18 PF13238.4 MSTRG.5044.1_3 - 0.036 14.4 0.0 0.17 12.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.24 MSTRG.5044.1_3 - 0.047 13.3 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Zeta_toxin PF06414.10 MSTRG.5044.1_3 - 0.061 12.5 0.0 0.15 11.2 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.4 MSTRG.5044.1_3 - 0.1 12.7 0.0 0.31 11.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain RRM_1 PF00076.20 MSTRG.26574.2_3 - 2.1e-29 101.0 0.1 3.9e-07 29.6 0.0 5.3 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 MSTRG.26574.2_3 - 0.016 15.1 0.0 0.14 12.1 0.0 2.3 2 0 0 2 2 2 0 RNA binding motif Clat_adaptor_s PF01217.18 MSTRG.23069.3_3 - 3.6e-42 143.5 0.6 4.6e-42 143.2 0.6 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain ETAA1 PF15350.4 MSTRG.19352.1_1 - 0.0015 16.8 1.1 0.0019 16.5 1.1 1.1 1 0 0 1 1 1 1 Ewing's tumour-associated antigen 1 homologue NTP_transferase PF00483.21 MSTRG.26558.1_3 - 1.4e-51 175.4 0.0 2.1e-51 174.8 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.5 MSTRG.26558.1_3 - 2.3e-09 37.6 0.0 3.4e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.22 MSTRG.26558.1_3 - 1.1e-08 34.3 3.0 1.1e-08 34.3 3.0 2.3 2 1 0 3 3 3 1 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.4 MSTRG.26558.1_3 - 3.1e-05 23.5 3.4 4.3e-05 23.0 1.7 2.0 2 0 0 2 2 2 1 Hexapeptide repeat of succinyl-transferase IspD PF01128.17 MSTRG.26558.1_3 - 0.072 12.7 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NICE-3 PF07406.9 MSTRG.12518.2_1 - 2.2e-49 167.8 0.0 3.6e-49 167.1 0.0 1.3 1 0 0 1 1 1 1 NICE-3 protein APC_basic PF05956.9 MSTRG.12518.2_1 - 0.05 12.9 5.5 0.074 12.4 5.5 1.1 1 0 0 1 1 1 0 APC basic domain Peptidase_M19 PF01244.19 MSTRG.11309.3_1 - 2.7e-119 397.9 0.0 3.2e-119 397.7 0.0 1.1 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) RRM_1 PF00076.20 MSTRG.9266.2_1 - 5.8e-17 61.1 0.0 9.1e-17 60.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.6 MSTRG.9266.2_1 - 0.0043 17.0 0.0 0.012 15.5 0.0 1.7 1 0 0 1 1 1 1 Limkain b1 RRM_7 PF16367.3 MSTRG.9266.2_1 - 0.0069 16.3 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif RRM_occluded PF16842.3 MSTRG.9266.2_1 - 0.039 13.7 0.0 0.077 12.7 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.4 MSTRG.9266.2_1 - 0.044 13.6 0.0 0.076 12.9 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Macoilin PF09726.7 MSTRG.9266.2_1 - 0.21 10.0 20.4 0.35 9.2 20.4 1.3 1 0 0 1 1 1 0 Transmembrane protein PI3K_1B_p101 PF10486.7 MSTRG.9266.2_1 - 1.4 6.5 17.5 1.9 6.1 17.5 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit PNISR PF15996.3 MSTRG.9266.2_1 - 2.4 8.2 20.1 5.1 7.1 20.1 1.5 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR LAP1C PF05609.10 MSTRG.9266.2_1 - 2.7 6.9 15.6 3.8 6.4 15.6 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) MIP-T3 PF10243.7 MSTRG.9266.2_1 - 4.9 5.6 41.1 7.6 5.0 41.1 1.4 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF126 PF01989.14 MSTRG.18923.1_2 - 0.019 14.6 1.0 0.036 13.7 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF126 MASE5 PF17178.2 MSTRG.18923.1_2 - 0.032 13.9 0.6 0.04 13.6 0.6 1.1 1 0 0 1 1 1 0 Membrane-associated sensor SH3_9 PF14604.4 MSTRG.18333.1_2 - 9.1e-12 44.5 0.0 1.9e-11 43.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.18333.1_2 - 1.7e-11 43.4 0.4 3.7e-11 42.3 0.1 1.8 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 MSTRG.18333.1_2 - 5.2e-11 41.9 0.1 9e-11 41.2 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain hSH3 PF14603.4 MSTRG.18333.1_2 - 0.0022 18.3 0.0 0.0045 17.3 0.0 1.4 1 0 0 1 1 1 1 Helically-extended SH3 domain RXT2_N PF08595.9 MSTRG.18333.1_2 - 0.012 15.5 8.0 0.82 9.6 0.8 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal ANAPC15 PF15243.4 MSTRG.18333.1_2 - 1.2 9.5 20.1 2.1 8.7 8.7 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 15 FAM176 PF14851.4 MSTRG.18333.1_2 - 3.2 7.3 13.0 9.7 5.7 5.2 2.5 2 0 0 2 2 2 0 FAM176 family NOA36 PF06524.10 MSTRG.18333.1_2 - 4.3 6.5 18.5 0.66 9.2 5.9 2.2 2 0 0 2 2 2 0 NOA36 protein DUF913 PF06025.10 MSTRG.18333.1_2 - 4.4 6.0 7.5 8 5.2 1.5 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) TFB6 PF17110.3 MSTRG.18333.1_2 - 7.6 6.1 10.2 0.85 9.2 2.0 2.4 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH DNA_pol_phi PF04931.11 MSTRG.18333.1_2 - 9.9 4.0 23.8 0.64 7.9 8.7 2.2 2 0 0 2 2 2 0 DNA polymerase phi PP2C PF00481.19 MSTRG.973.2_3 - 1.7e-64 217.8 0.0 2.2e-64 217.4 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.4 MSTRG.973.2_3 - 0.00092 18.8 0.1 0.002 17.6 0.1 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.10 MSTRG.973.2_3 - 0.033 14.0 0.4 0.44 10.3 0.4 2.2 1 1 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) Nop14 PF04147.10 MSTRG.973.2_3 - 0.36 8.9 5.1 0.5 8.4 5.1 1.1 1 0 0 1 1 1 0 Nop14-like family Paf1 PF03985.11 MSTRG.973.2_3 - 0.86 8.4 8.7 1.3 7.8 8.7 1.1 1 0 0 1 1 1 0 Paf1 Usp PF00582.24 MSTRG.973.2_3 - 1.2 9.5 7.0 2.4 8.5 7.0 1.4 1 0 0 1 1 1 0 Universal stress protein family DUF1510 PF07423.9 MSTRG.973.2_3 - 1.3 8.3 5.9 1.9 7.8 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) SDA1 PF05285.10 MSTRG.973.2_3 - 1.3 8.3 7.1 1.9 7.7 7.1 1.1 1 0 0 1 1 1 0 SDA1 Neurokinin_B PF03823.12 MSTRG.4092.1_2 - 0.03 14.2 0.1 0.13 12.1 0.1 2.2 1 0 0 1 1 1 0 Neurokinin B DUF1669 PF07894.10 MSTRG.4092.1_3 - 3.1e-29 102.2 1.4 6.2e-29 101.3 1.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1669) BTB_3 PF16017.3 MSTRG.12309.1_1 - 1.7e-50 169.4 0.0 2.6e-50 168.8 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BTB_2 PF02214.20 MSTRG.12309.1_1 - 0.0052 17.0 0.0 0.01 16.0 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Sema PF01403.17 MSTRG.13693.1_1 - 2.1e-24 85.9 0.0 2.8e-24 85.5 0.0 1.1 1 0 0 1 1 1 1 Sema domain p450 PF00067.20 MSTRG.23955.1_1 - 3.2e-125 418.4 0.0 3.8e-125 418.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 VHS PF00790.17 MSTRG.27718.1_1 - 3.5e-35 120.8 0.0 7.9e-35 119.6 0.0 1.5 1 0 0 1 1 1 1 VHS domain GAT PF03127.12 MSTRG.27718.1_1 - 1.5e-14 53.9 0.2 3.7e-14 52.7 0.2 1.7 1 0 0 1 1 1 1 GAT domain Alpha_adaptinC2 PF02883.18 MSTRG.27718.1_2 - 3e-20 72.5 0.0 4.7e-20 71.8 0.0 1.3 1 0 0 1 1 1 1 Adaptin C-terminal domain tRNA-synt_1c PF00749.19 MSTRG.27718.1_3 - 1e-84 284.0 0.0 1.3e-84 283.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain zf-H2C2_2 PF13465.4 MSTRG.15093.1_3 - 1.2e-52 173.9 64.6 1.7e-08 34.4 0.3 9.3 9 0 0 9 9 8 7 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.15093.1_3 - 1.7e-33 113.1 86.3 2.1e-05 24.6 3.7 9.3 9 0 0 9 9 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.15093.1_3 - 2.5e-21 74.4 71.8 0.0019 18.7 0.9 9.3 9 0 0 9 9 9 8 C2H2-type zinc finger zf-LYAR PF08790.9 MSTRG.15093.1_3 - 2.8e-15 55.8 51.3 0.0018 18.0 0.6 8.4 8 0 0 8 8 8 6 LYAR-type C2HC zinc finger zf-met PF12874.5 MSTRG.15093.1_3 - 5e-08 32.9 45.3 0.24 11.7 0.7 7.8 7 0 0 7 7 7 5 Zinc-finger of C2H2 type zf-trcl PF13451.4 MSTRG.15093.1_3 - 1e-05 25.2 42.7 0.42 10.4 0.3 9.1 9 0 0 9 9 9 5 Probable zinc-ribbon domain zf-HYPF PF07503.10 MSTRG.15093.1_3 - 3.7e-05 23.3 40.3 1.3 8.7 0.2 8.8 9 0 0 9 9 9 5 HypF finger zf-C2HE PF16278.3 MSTRG.15093.1_3 - 0.0064 16.8 56.1 0.85 10.0 0.5 8.8 2 1 6 8 8 7 4 C2HE / C2H2 / C2HC zinc-binding finger LIM PF00412.20 MSTRG.15093.1_3 - 0.008 16.3 53.0 2.5 8.3 3.3 8.7 2 1 7 9 9 8 2 LIM domain Zn-ribbon_8 PF09723.8 MSTRG.15093.1_3 - 0.008 16.1 50.8 0.062 13.3 2.4 7.2 2 2 6 8 8 7 6 Zinc ribbon domain zinc_ribbon_15 PF17032.3 MSTRG.15093.1_3 - 0.052 14.2 40.0 0.09 13.4 1.1 5.5 1 1 7 8 8 7 0 zinc-ribbon family zf-C2H2_11 PF16622.3 MSTRG.15093.1_3 - 0.073 12.7 0.3 0.073 12.7 0.3 9.3 10 0 0 10 10 9 0 zinc-finger C2H2-type DUF3268 PF11672.6 MSTRG.15093.1_3 - 0.15 12.3 23.3 0.93 9.7 0.3 4.5 3 1 1 5 5 4 0 zinc-finger-containing domain CCSAP PF15748.3 MSTRG.15093.1_3 - 0.35 10.9 4.2 11 6.0 4.2 2.5 1 1 0 1 1 1 0 Centriole, cilia and spindle-associated BolA PF01722.16 MSTRG.15093.1_3 - 0.94 9.7 13.7 1e+02 3.1 10.2 4.2 1 1 2 3 3 3 0 BolA-like protein zf-AN1 PF01428.14 MSTRG.15093.1_3 - 1 9.4 61.7 2.3 8.3 3.1 9.2 6 2 3 9 9 9 0 AN1-like Zinc finger YhfH PF14149.4 MSTRG.15093.1_3 - 2.8 7.9 34.9 20 5.1 0.1 8.3 8 0 0 8 8 8 0 YhfH-like protein zf-C2H2_6 PF13912.4 MSTRG.15093.1_3 - 3.4 7.6 49.2 0.47 10.3 2.1 8.9 8 1 0 8 8 8 0 C2H2-type zinc finger Fer4_17 PF13534.4 MSTRG.15093.1_3 - 8.4 6.9 33.3 76 3.8 0.3 6.5 1 1 4 5 5 5 0 4Fe-4S dicluster domain CpXC PF14353.4 MSTRG.15093.1_3 - 8.8 6.3 34.4 13 5.7 1.1 7.5 4 3 2 7 7 7 0 CpXC protein Dimer_Tnp_hAT PF05699.12 MSTRG.21514.1_2 - 3e-19 68.5 0.0 7.8e-19 67.1 0.0 1.8 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region zf-BED PF02892.13 MSTRG.21514.1_2 - 1.7e-06 27.8 0.2 4.5e-06 26.5 0.2 1.8 1 0 0 1 1 1 1 BED zinc finger DUF659 PF04937.13 MSTRG.21514.1_2 - 0.00075 19.2 0.0 0.0016 18.2 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) DBD_Tnp_Hermes PF10683.7 MSTRG.21514.1_2 - 0.0041 16.6 0.0 0.0088 15.6 0.0 1.5 1 0 0 1 1 1 1 Hermes transposase DNA-binding domain DUF4413 PF14372.4 MSTRG.21514.1_2 - 0.038 14.2 0.0 0.11 12.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) Rhomboid_SP PF12595.6 MSTRG.5258.3_1 - 8.2e-112 371.7 3.2 1.2e-111 371.2 3.2 1.2 1 0 0 1 1 1 1 Rhomboid serine protease Rhomboid PF01694.20 MSTRG.5258.3_1 - 5.8e-28 97.6 9.8 5.8e-28 97.6 9.8 1.7 2 0 0 2 2 2 1 Rhomboid family Tet_JBP PF12851.5 MSTRG.27668.1_1 - 9.7e-111 370.2 0.1 4e-110 368.1 0.0 2.2 2 1 0 2 2 2 1 Oxygenase domain of the 2OGFeDO superfamily Ndr PF03096.12 MSTRG.8205.1_3 - 7.5e-110 365.9 0.0 9.3e-110 365.6 0.0 1.1 1 0 0 1 1 1 1 Ndr family PH PF00169.27 MSTRG.29759.1_3 - 4.6e-16 59.1 0.1 6.8e-16 58.6 0.1 1.3 1 0 0 1 1 1 1 PH domain C1_1 PF00130.20 MSTRG.29759.1_3 - 7.2e-10 38.5 11.8 1.5e-09 37.5 11.8 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PH_3 PF14593.4 MSTRG.29759.1_3 - 9.6e-06 25.5 0.1 1.3e-05 25.1 0.1 1.2 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 MSTRG.29759.1_3 - 1.7e-05 24.9 0.2 2.9e-05 24.1 0.2 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.4 MSTRG.29759.1_3 - 8.1e-05 22.9 5.8 0.00027 21.2 2.1 2.7 2 2 0 2 2 2 1 Pleckstrin homology domain C1_2 PF03107.14 MSTRG.29759.1_3 - 0.00031 20.9 5.5 0.00083 19.5 5.5 1.8 1 1 0 1 1 1 1 C1 domain Mcp5_PH PF12814.5 MSTRG.29759.1_3 - 0.0038 17.2 0.1 0.0063 16.5 0.1 1.5 1 1 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PHD PF00628.27 MSTRG.29759.1_3 - 0.1 12.4 6.0 0.26 11.1 6.0 1.7 1 0 0 1 1 1 0 PHD-finger NIF3 PF01784.16 MSTRG.160.2_2 - 6.8e-72 241.9 0.0 8.9e-72 241.5 0.0 1.1 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) Myb_DNA-bind_4 PF13837.4 MSTRG.11864.1_3 - 3e-12 46.6 0.1 5.2e-12 45.9 0.1 1.4 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.7 MSTRG.11864.1_3 - 0.00018 21.6 0.2 0.00037 20.6 0.2 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Topoisom_bac PF01131.18 MSTRG.18691.1_2 - 3.3e-112 375.4 0.0 4e-112 375.1 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase zf-GRF PF06839.10 MSTRG.18691.1_2 - 4.5e-32 109.8 12.2 1.5e-17 63.3 4.8 3.5 4 0 0 4 4 4 2 GRF zinc finger Toprim PF01751.20 MSTRG.18691.1_2 - 4.1e-15 55.7 0.0 1.6e-14 53.8 0.0 2.0 2 0 0 2 2 2 1 Toprim domain zf-C4_Topoisom PF01396.17 MSTRG.18691.1_2 - 5.5e-11 41.9 1.4 5.5e-11 41.9 1.4 3.1 4 0 0 4 4 4 1 Topoisomerase DNA binding C4 zinc finger zf-C2H2_10 PF16588.3 MSTRG.18691.1_2 - 0.081 12.5 2.2 0.21 11.2 2.2 1.7 1 0 0 1 1 1 0 C2H2 zinc-finger DUF2256 PF10013.7 MSTRG.18691.1_2 - 0.098 12.7 0.2 0.098 12.7 0.2 2.5 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) Ion_trans_2 PF07885.14 MSTRG.27076.1_1 - 1.9e-32 111.0 14.3 5.7e-16 58.1 1.4 3.0 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.29 MSTRG.27076.1_1 - 0.015 14.4 12.3 0.38 9.8 0.3 2.3 2 0 0 2 2 2 0 Ion transport protein Laminin_G_2 PF02210.22 MSTRG.9473.1_2 - 6.8e-19 68.6 0.0 1.1e-18 67.9 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.21 MSTRG.9473.1_2 - 1.7e-07 31.3 0.0 2.9e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain Syndecan PF01034.18 MSTRG.9473.1_2 - 1.1e-06 28.3 0.0 2.1e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Syndecan domain Laminin_G_3 PF13385.4 MSTRG.9473.1_2 - 0.016 15.3 0.1 0.027 14.5 0.1 1.3 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily DUF202 PF02656.13 MSTRG.9473.1_2 - 0.025 14.9 0.0 0.063 13.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) BAAT_C PF08840.9 MSTRG.24279.1_1 - 2.2e-51 174.7 0.0 3.3e-51 174.1 0.0 1.2 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Bile_Hydr_Trans PF04775.12 MSTRG.24279.1_1 - 7.3e-36 122.8 0.0 1.1e-35 122.3 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA thioester hydrolase/BAAT N-terminal region DLH PF01738.16 MSTRG.24279.1_1 - 2.3e-08 33.7 0.1 0.00031 20.2 0.0 2.5 2 1 0 2 2 2 2 Dienelactone hydrolase family Peptidase_S9 PF00326.19 MSTRG.24279.1_1 - 2.3e-06 27.1 0.1 4.4e-05 22.9 0.1 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family FSH1 PF03959.11 MSTRG.24279.1_1 - 0.033 13.7 0.0 0.14 11.6 0.0 1.8 1 1 1 2 2 2 0 Serine hydrolase (FSH1) SIR2 PF02146.15 MSTRG.5936.1_3 - 2.7e-54 183.7 0.0 5.2e-54 182.7 0.0 1.5 1 0 0 1 1 1 1 Sir2 family Fox-1_C PF12414.6 MSTRG.4796.1_2 - 8.3e-41 138.1 21.4 1.6e-40 137.1 21.4 1.5 1 0 0 1 1 1 1 Calcitonin gene-related peptide regulator C terminal RRM_1 PF00076.20 MSTRG.4796.1_2 - 0.00021 20.9 0.0 0.00036 20.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3277 PF11681.6 MSTRG.2713.1_1 - 0.057 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3277) ydhR PF08803.9 MSTRG.2713.1_1 - 0.11 12.2 0.1 0.22 11.3 0.1 1.4 1 0 0 1 1 1 0 Putative mono-oxygenase ydhR APCDDC PF14921.4 MSTRG.2713.1_3 - 3.4e-115 383.3 1.0 3.3e-89 298.2 0.7 2.3 2 0 0 2 2 2 2 Adenomatosis polyposis coli down-regulated 1 ORC5_C PF14630.4 MSTRG.21836.3_2 - 2.4e-67 227.4 1.0 3.1e-67 227.0 1.0 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.4 MSTRG.21836.3_2 - 2.4e-13 50.7 0.1 4.8e-13 49.7 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 MSTRG.21836.3_2 - 0.00023 21.3 0.1 0.0018 18.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain Lentivirus_VIF PF05851.9 MSTRG.14247.1_1 - 0.018 13.8 0.7 0.055 12.2 0.0 1.8 2 0 0 2 2 2 0 Lentivirus virion infectivity factor (VIF) S-methyl_trans PF02574.14 MSTRG.21122.1_2 - 7.9e-55 186.4 0.0 1.1e-54 185.9 0.0 1.2 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Pterin_bind PF00809.20 MSTRG.21122.1_2 - 9e-47 159.7 0.0 1.1e-45 156.1 0.1 2.0 2 0 0 2 2 2 1 Pterin binding enzyme MtrH PF02007.16 MSTRG.21122.1_2 - 0.00016 20.8 0.0 0.00028 20.0 0.0 1.3 1 0 0 1 1 1 1 Tetrahydromethanopterin S-methyltransferase MtrH subunit CdhD PF03599.14 MSTRG.21122.1_2 - 0.01 14.4 0.0 0.015 13.9 0.0 1.3 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit UCH PF00443.27 MSTRG.3070.1_1 - 1.7e-15 57.1 0.1 2.2e-15 56.8 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 MSTRG.3070.1_1 - 2.7e-12 46.8 0.4 4.8e-12 46.0 0.4 1.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase FBD PF08387.8 MSTRG.3070.1_1 - 0.031 14.0 0.0 0.082 12.7 0.0 1.7 1 0 0 1 1 1 0 FBD RasGEF PF00617.17 MSTRG.24885.1_2 - 2.2e-53 180.8 1.0 3.3e-53 180.3 1.0 1.3 1 0 0 1 1 1 1 RasGEF domain Atg8 PF02991.14 MSTRG.1045.1_2 - 6e-47 158.0 0.1 9.1e-47 157.4 0.1 1.3 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.11 MSTRG.1045.1_2 - 1.2e-06 28.7 0.0 1.9e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Myosin_head PF00063.19 MSTRG.8810.1_2 - 3e-20 71.9 0.2 4.1e-20 71.5 0.2 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.25 MSTRG.8810.1_2 - 0.0013 18.2 17.2 0.35 10.7 0.5 3.6 3 0 0 3 3 3 3 IQ calmodulin-binding motif Ribosomal_S17e PF00833.16 MSTRG.17596.1_3 - 1.3e-67 225.2 0.3 1.5e-67 224.9 0.3 1.0 1 0 0 1 1 1 1 Ribosomal S17 Collagen PF01391.16 MSTRG.17144.5_3 - 1.3e-157 511.6 646.3 2.7e-08 33.3 27.8 20.1 1 1 12 13 13 13 8 Collagen triple helix repeat (20 copies) COLFI PF01410.16 MSTRG.17144.5_3 - 5.7e-93 310.4 0.0 7.1e-93 310.1 0.0 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain PDGF PF00341.15 MSTRG.3394.1_1 - 1.6e-23 82.6 6.7 3.7e-23 81.5 6.7 1.6 1 0 0 1 1 1 1 PDGF/VEGF domain IBN_N PF03810.17 MSTRG.3394.1_1 - 0.068 13.0 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Importin-beta N-terminal domain VEGF_C PF14554.4 MSTRG.3394.1_1 - 0.59 10.1 19.1 0.27 11.2 15.6 2.3 2 0 0 2 2 2 0 VEGF heparin-binding domain Toxin_20 PF08089.9 MSTRG.3394.1_2 - 0.025 14.5 7.8 0.2 11.6 0.2 2.4 2 0 0 2 2 2 0 Huwentoxin-II family Myotub-related PF06602.12 MSTRG.16548.1_1 - 1.3e-138 461.5 0.0 2.1e-138 460.8 0.0 1.3 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain FYVE PF01363.19 MSTRG.16548.1_1 - 6.8e-18 64.4 10.5 6.8e-18 64.4 10.5 2.8 2 0 0 2 2 2 1 FYVE zinc finger Y_phosphatase PF00102.25 MSTRG.16548.1_1 - 0.0012 18.3 0.0 0.0024 17.4 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.18 MSTRG.16548.1_1 - 0.0044 16.7 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 MSTRG.16548.1_1 - 0.0087 15.9 0.0 0.019 14.8 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family SoxG PF04268.10 MSTRG.16548.1_1 - 0.019 15.0 0.5 0.051 13.6 0.3 1.8 2 0 0 2 2 2 0 Sarcosine oxidase, gamma subunit family FYVE_2 PF02318.14 MSTRG.16548.1_1 - 0.049 13.7 15.4 0.39 10.8 5.7 3.0 2 0 0 2 2 2 0 FYVE-type zinc finger Ribosomal_L32p PF01783.21 MSTRG.16548.1_1 - 4.7 7.4 7.5 0.53 10.5 0.7 2.9 3 0 0 3 3 3 0 Ribosomal L32p protein family CBM_20 PF00686.17 MSTRG.2379.2_2 - 1e-13 50.8 0.0 2e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 Starch binding domain RCC1 PF00415.16 MSTRG.25039.1_3 - 4.9e-31 107.0 26.1 2.6e-09 37.4 1.9 6.1 5 2 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 MSTRG.25039.1_3 - 9.8e-20 69.7 36.5 6.4e-05 22.5 2.1 5.5 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat DUF370 PF04025.10 MSTRG.25039.1_3 - 0.007 16.3 0.0 0.52 10.3 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF370) RCC1 PF00415.16 MSTRG.22360.1_1 - 2.1e-60 201.0 25.5 6.5e-14 52.2 2.2 6.3 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 MSTRG.22360.1_1 - 9.3e-31 104.8 27.7 9.1e-10 38.0 1.1 6.7 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.29 MSTRG.22360.1_1 - 1.5e-20 73.3 0.6 5.7e-19 68.2 0.1 2.3 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.13 MSTRG.22360.1_1 - 0.00055 19.9 2.2 0.0093 15.9 0.1 2.8 2 1 0 2 2 2 1 BTB And C-terminal Kelch 3HCDH_N PF02737.16 MSTRG.1460.1_2 - 8.7e-47 159.2 0.0 1.2e-46 158.7 0.0 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.20 MSTRG.1460.1_2 - 9.8e-16 58.0 0.0 2.2e-15 56.9 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_Gly3P_dh_N PF01210.21 MSTRG.1460.1_2 - 0.011 15.5 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_8 PF13450.4 MSTRG.1460.1_2 - 0.026 14.6 0.0 0.05 13.7 0.0 1.4 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.25 MSTRG.1460.1_2 - 0.028 14.8 0.0 0.058 13.8 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.12 MSTRG.1460.1_2 - 0.03 13.4 0.0 0.049 12.7 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.12 MSTRG.1460.1_2 - 0.035 13.6 0.0 0.055 12.9 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.17 MSTRG.1460.1_2 - 0.044 13.0 0.0 0.071 12.3 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.13 MSTRG.1460.1_2 - 0.054 13.5 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.14 MSTRG.1460.1_2 - 0.12 11.9 0.0 0.2 11.1 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA EF_assoc_2 PF08356.10 MSTRG.27849.6_2 - 1.9e-36 123.8 0.0 4.4e-36 122.6 0.0 1.7 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.10 MSTRG.27849.6_2 - 4.9e-28 96.4 1.7 2.5e-27 94.2 1.0 2.2 2 0 0 2 2 2 1 EF hand associated Ras PF00071.20 MSTRG.27849.6_2 - 1.6e-24 86.2 0.0 2.8e-18 65.9 0.0 2.4 2 0 0 2 2 2 2 Ras family Roc PF08477.11 MSTRG.27849.6_2 - 1.7e-09 37.8 0.5 1.2e-07 31.8 0.0 3.3 3 1 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 MSTRG.27849.6_2 - 2.9e-08 33.2 0.1 5.4e-08 32.3 0.1 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit EF-hand_1 PF00036.30 MSTRG.27849.6_2 - 1.9e-05 23.7 1.8 0.052 13.0 0.1 2.6 2 0 0 2 2 2 2 EF hand DUF258 PF03193.14 MSTRG.27849.6_2 - 1.9e-05 24.5 0.3 0.37 10.6 0.1 3.6 3 0 0 3 3 3 1 Protein of unknown function, DUF258 Arf PF00025.19 MSTRG.27849.6_2 - 2e-05 24.0 0.0 4.7e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 MSTRG.27849.6_2 - 8.2e-05 22.5 0.0 0.013 15.4 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase EF-hand_7 PF13499.4 MSTRG.27849.6_2 - 9.3e-05 22.7 0.1 0.62 10.5 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair Dynamin_N PF00350.21 MSTRG.27849.6_2 - 0.00025 21.0 0.1 0.11 12.4 0.1 2.4 2 0 0 2 2 2 1 Dynamin family EF-hand_6 PF13405.4 MSTRG.27849.6_2 - 0.00033 20.2 3.9 0.0052 16.5 0.4 2.7 2 0 0 2 2 2 1 EF-hand domain PduV-EutP PF10662.7 MSTRG.27849.6_2 - 0.0023 17.5 0.2 2.3 7.8 0.0 3.2 3 1 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.4 MSTRG.27849.6_2 - 0.012 15.8 0.0 4.9 7.3 0.0 2.7 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.25 MSTRG.27849.6_2 - 0.016 15.6 0.0 6 7.2 0.0 2.3 2 0 0 2 2 2 0 ABC transporter EF-hand_8 PF13833.4 MSTRG.27849.6_2 - 0.024 14.3 0.4 1.4 8.6 0.0 2.8 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.27849.6_2 - 0.036 13.5 2.3 3 7.4 0.0 2.6 2 0 0 2 2 2 0 EF hand MCM PF00493.21 MSTRG.27849.6_2 - 0.043 12.8 0.0 1.3 7.9 0.0 2.2 2 0 0 2 2 2 0 MCM2/3/5 family Septin PF00735.16 MSTRG.27849.6_2 - 0.053 12.6 0.0 7.4 5.6 0.0 2.2 2 0 0 2 2 2 0 Septin AAA_25 PF13481.4 MSTRG.27849.6_2 - 0.092 12.2 0.0 0.24 10.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA PF00004.27 MSTRG.27849.6_2 - 0.095 13.0 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.20 MSTRG.27849.6_2 - 0.11 12.8 0.0 21 5.4 0.0 2.8 3 0 0 3 3 2 0 RNA helicase FeoB_N PF02421.16 MSTRG.27849.6_2 - 0.14 11.5 0.3 0.92 8.9 0.3 2.2 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_29 PF13555.4 MSTRG.27849.6_2 - 0.16 11.6 0.1 3.3 7.4 0.0 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain Sec7 PF01369.18 MSTRG.27418.2_1 - 2.4e-11 43.6 0.0 3.6e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain Golgin_A5 PF09787.7 MSTRG.27418.2_1 - 0.035 13.4 0.5 0.052 12.9 0.5 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 Sec7 PF01369.18 MSTRG.27418.2_3 - 3.1e-48 163.8 0.1 4.4e-48 163.3 0.1 1.2 1 0 0 1 1 1 1 Sec7 domain PH PF00169.27 MSTRG.27418.2_3 - 7.4e-25 87.4 0.0 1.3e-24 86.6 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 MSTRG.27418.2_3 - 0.00039 20.7 0.1 0.00079 19.7 0.1 1.6 1 1 0 1 1 1 1 Pleckstrin homology domain Lectin_C PF00059.19 MSTRG.20834.3_3 - 6.7e-25 87.8 0.9 1.7e-24 86.5 0.9 1.8 1 0 0 1 1 1 1 Lectin C-type domain HALZ PF02183.16 MSTRG.20834.3_3 - 3.2e-12 46.3 90.8 0.013 15.6 2.8 14.2 4 2 10 14 14 14 9 Homeobox associated leucine zipper JIP_LZII PF16471.3 MSTRG.20834.3_3 - 5e-11 42.5 57.4 0.0024 17.9 0.9 8.4 3 2 6 9 9 9 4 JNK-interacting protein leucine zipper II APG6 PF04111.10 MSTRG.20834.3_3 - 5.7e-08 32.4 70.7 0.037 13.3 12.4 5.1 1 1 4 5 5 5 4 Autophagy protein Apg6 Spc7 PF08317.9 MSTRG.20834.3_3 - 1.9e-06 26.9 62.9 0.048 12.4 2.6 5.3 1 1 4 5 5 5 5 Spc7 kinetochore protein Scaffolding_pro PF11418.6 MSTRG.20834.3_3 - 2.7e-05 24.5 31.0 2.4 8.7 0.1 7.7 2 1 7 9 9 9 3 Phi29 scaffolding protein SHE3 PF17078.3 MSTRG.20834.3_3 - 0.00015 21.5 28.5 0.00015 21.5 28.5 3.6 1 1 1 3 3 3 1 SWI5-dependent HO expression protein 3 TMF_TATA_bd PF12325.6 MSTRG.20834.3_3 - 0.0026 17.8 57.9 0.35 11.0 4.9 7.5 1 1 7 9 9 9 3 TATA element modulatory factor 1 TATA binding KASH_CCD PF14662.4 MSTRG.20834.3_3 - 0.0059 16.3 64.5 0.86 9.3 22.3 5.7 1 1 3 4 4 4 2 Coiled-coil region of CCDC155 or KASH DUF3450 PF11932.6 MSTRG.20834.3_3 - 0.018 14.2 62.5 0.041 13.0 8.6 6.4 1 1 4 7 7 7 0 Protein of unknown function (DUF3450) GAS PF13851.4 MSTRG.20834.3_3 - 0.019 14.2 70.7 0.039 13.2 16.2 6.1 1 1 5 6 6 6 0 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.7 MSTRG.20834.3_3 - 0.027 14.4 63.5 0.11 12.3 8.8 6.5 1 1 6 7 7 7 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF2353 PF09789.7 MSTRG.20834.3_3 - 0.042 13.1 67.7 0.053 12.8 20.4 4.3 1 1 3 4 4 4 0 Uncharacterized coiled-coil protein (DUF2353) DUF1664 PF07889.10 MSTRG.20834.3_3 - 0.067 13.1 36.1 0.085 12.7 1.0 5.7 3 1 3 6 6 6 0 Protein of unknown function (DUF1664) DUF4407 PF14362.4 MSTRG.20834.3_3 - 0.081 12.1 45.0 0.26 10.5 5.3 3.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) WXG100 PF06013.10 MSTRG.20834.3_3 - 0.39 10.8 24.7 1.4 9.0 0.6 6.5 6 1 1 7 7 7 0 Proteins of 100 residues with WXG ZapB PF06005.10 MSTRG.20834.3_3 - 0.41 11.0 63.5 4.5 7.6 2.8 8.3 4 1 4 8 8 7 0 Cell division protein ZapB DUF4472 PF14739.4 MSTRG.20834.3_3 - 1.1 9.8 53.9 3.3 8.3 3.7 7.3 1 1 6 8 8 8 0 Domain of unknown function (DUF4472) DUF5082 PF16888.3 MSTRG.20834.3_3 - 1.8 8.8 52.1 0.33 11.2 3.7 6.7 3 2 4 7 7 7 0 Domain of unknown function (DUF5082) CALCOCO1 PF07888.9 MSTRG.20834.3_3 - 4.1 5.7 58.5 1.3 7.4 13.9 3.3 1 1 2 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like Sec34 PF04136.13 MSTRG.20834.3_3 - 5.9 6.6 52.6 0.25 11.1 8.6 6.9 2 2 3 7 7 7 0 Sec34-like family CASP_C PF08172.10 MSTRG.20834.3_3 - 7.6 5.7 48.7 0.16 11.1 12.1 4.9 3 2 2 5 5 5 0 CASP C terminal Arm PF00514.21 MSTRG.6319.1_2 - 2.6e-43 144.7 8.3 9.6e-10 38.0 0.1 9.0 9 0 0 9 9 9 7 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.4 MSTRG.6319.1_2 - 1.3e-06 28.5 1.2 0.41 11.0 0.0 4.9 4 0 0 4 4 4 3 HEAT-like repeat HEAT_2 PF13646.4 MSTRG.6319.1_2 - 2.3e-06 27.8 0.7 0.019 15.2 0.0 2.8 2 1 0 2 2 2 2 HEAT repeats HEAT PF02985.20 MSTRG.6319.1_2 - 8.7e-05 22.3 3.7 10 6.5 0.0 5.2 6 0 0 6 6 6 2 HEAT repeat Aldedh PF00171.20 MSTRG.3083.1_2 - 3.2e-65 220.3 0.0 4e-65 220.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Fe-ADH PF00465.17 MSTRG.3083.1_2 - 0.16 10.6 0.0 0.25 10.0 0.0 1.2 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase Pkinase_Tyr PF07714.15 MSTRG.10671.1_1 - 7.8e-92 307.1 0.5 1.2e-91 306.5 0.5 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.10671.1_1 - 4.5e-48 163.8 0.1 7.8e-48 163.0 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 MSTRG.10671.1_1 - 1.5e-41 140.1 0.0 1.6e-22 79.2 0.1 2.5 2 0 0 2 2 2 2 SH2 domain NGP1NT PF08153.10 MSTRG.671.1_3 - 0.025 14.6 0.1 0.031 14.3 0.1 1.1 1 0 0 1 1 1 0 NGP1NT (NUC091) domain Beta-lactamase PF00144.22 MSTRG.11067.2_2 - 1.6e-43 149.1 0.0 1.8e-42 145.6 0.0 1.9 1 1 0 1 1 1 1 Beta-lactamase DUF3752 PF12572.6 MSTRG.11067.2_2 - 0.47 10.8 3.1 1.1 9.7 3.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3752) zf-H2C2_2 PF13465.4 MSTRG.12101.1_1 - 5.2e-51 168.8 103.0 7.2e-07 29.2 2.8 13.9 13 0 0 13 13 13 13 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.12101.1_1 - 8.8e-41 136.0 118.8 2.3e-05 24.4 4.2 13.6 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.12101.1_1 - 3.7e-28 95.6 112.5 0.0091 16.6 1.3 13.9 13 0 0 13 13 13 13 C2H2-type zinc finger BTB PF00651.29 MSTRG.12101.1_1 - 1.3e-17 63.9 1.0 2.4e-17 63.0 0.1 1.9 2 0 0 2 2 2 1 BTB/POZ domain zf-C2H2_jaz PF12171.6 MSTRG.12101.1_1 - 4.9e-08 32.9 60.2 0.081 13.1 2.9 12.5 11 1 1 12 12 12 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 MSTRG.12101.1_1 - 1.9e-07 30.7 92.1 0.0012 18.6 3.2 12.8 13 0 0 13 13 13 7 C2H2-type zinc finger zf-met PF12874.5 MSTRG.12101.1_1 - 1.5e-05 25.0 80.4 0.00048 20.3 0.5 12.4 13 0 0 13 13 13 5 Zinc-finger of C2H2 type zf-MIZ PF02891.18 MSTRG.12101.1_1 - 0.083 12.5 0.1 0.083 12.5 0.1 6.4 9 0 0 9 9 9 0 MIZ/SP-RING zinc finger zf-RING_11 PF17123.3 MSTRG.12101.1_1 - 0.098 12.3 5.4 25 4.5 0.2 5.0 4 0 0 4 4 4 0 RING-like zinc finger Trm112p PF03966.14 MSTRG.12101.1_1 - 3.3 8.2 11.7 1.2 9.6 2.0 4.2 3 1 0 3 3 3 0 Trm112p-like protein Ribosomal_L13 PF00572.16 MSTRG.1815.1_1 - 1.4e-09 38.1 0.0 1.3e-08 35.0 0.0 2.3 1 1 0 1 1 1 1 Ribosomal protein L13 ArgoN PF16486.3 MSTRG.1815.1_1 - 0.047 14.3 0.1 0.071 13.7 0.1 1.3 1 0 0 1 1 1 0 N-terminal domain of argonaute Spectrin PF00435.19 MSTRG.7672.3_3 - 1.9e-150 491.0 182.8 2.4e-17 63.2 7.5 18.2 18 1 0 18 18 18 17 Spectrin repeat GAS2 PF02187.15 MSTRG.7672.3_3 - 1.2e-30 105.3 0.2 3.6e-30 103.7 0.2 2.0 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain EF-hand_1 PF00036.30 MSTRG.7672.3_3 - 2.1e-12 45.5 1.4 8.2e-05 21.8 0.4 3.1 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 MSTRG.7672.3_3 - 4.8e-11 41.5 0.9 0.00054 19.6 0.0 3.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.4 MSTRG.7672.3_3 - 1.8e-10 41.0 0.6 1.1e-09 38.5 0.6 2.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.7672.3_3 - 1.1e-08 34.1 2.9 1.9e-05 23.8 0.7 3.0 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.4 MSTRG.7672.3_3 - 7.8e-07 28.6 0.6 5.6e-06 25.9 0.1 2.5 1 1 1 2 2 2 2 EF-hand domain pair MitMem_reg PF13012.4 MSTRG.7672.3_3 - 0.0062 16.9 0.5 0.0062 16.9 0.5 5.4 6 2 0 6 6 6 1 Maintenance of mitochondrial structure and function Laminin_II PF06009.10 MSTRG.7672.3_3 - 0.0072 16.2 1.1 0.0072 16.2 1.1 13.5 13 2 1 14 14 14 3 Laminin Domain II Jacalin PF01419.15 MSTRG.9602.4_1 - 2e-06 27.7 0.1 4.2e-06 26.6 0.1 1.5 1 1 0 1 1 1 1 Jacalin-like lectin domain PH PF00169.27 MSTRG.15250.1_1 - 2.3e-17 63.3 1.3 5e-17 62.2 0.4 2.0 2 0 0 2 2 2 1 PH domain PH_3 PF14593.4 MSTRG.15250.1_1 - 1.5e-06 28.2 0.2 4.5e-06 26.6 0.2 1.9 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 MSTRG.15250.1_1 - 5.9e-05 23.3 4.2 5.9e-05 23.3 4.2 3.1 2 2 0 2 2 2 1 Pleckstrin homology domain PH_2 PF08458.8 MSTRG.15250.1_1 - 0.00074 19.7 0.1 0.00074 19.7 0.1 2.1 2 0 0 2 2 2 1 Plant pleckstrin homology-like region DUF2316 PF10078.7 MSTRG.15250.1_1 - 0.011 15.9 10.2 0.025 14.7 5.8 2.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2316) EF-hand_7 PF13499.4 MSTRG.15250.1_1 - 1.7 9.0 0.0 1.7 9.0 0.0 3.6 4 0 0 4 4 4 0 EF-hand domain pair zf-MIZ PF02891.18 MSTRG.16766.1_1 - 5.1e-23 80.4 4.4 5.1e-23 80.4 4.4 2.7 2 0 0 2 2 2 2 MIZ/SP-RING zinc finger zf-Nse PF11789.6 MSTRG.16766.1_1 - 7.2e-06 25.6 0.9 7.2e-06 25.6 0.9 2.4 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit TLE_N PF03920.13 MSTRG.23706.1_1 - 5.3e-59 197.9 8.8 9e-59 197.1 8.8 1.2 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain WD40 PF00400.30 MSTRG.23706.1_1 - 9.1e-17 61.0 22.5 0.01 16.5 0.9 7.5 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.23706.1_1 - 2.4e-07 30.8 0.0 0.48 10.6 0.0 4.5 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 MSTRG.23706.1_1 - 0.01 15.0 0.0 1.8 7.7 0.0 2.5 2 0 0 2 2 2 0 WD40-like domain GHMP_kinases_N PF00288.24 MSTRG.23706.1_1 - 0.15 12.2 0.1 0.15 12.2 0.1 3.6 4 0 0 4 4 4 0 GHMP kinases N terminal domain DUF676 PF05057.12 MSTRG.7906.1_2 - 0.01 15.2 0.1 0.012 15.0 0.1 1.1 1 0 0 1 1 1 0 Putative serine esterase (DUF676) PGAP1 PF07819.11 MSTRG.7906.1_2 - 0.15 11.6 0.0 0.17 11.4 0.0 1.1 1 0 0 1 1 1 0 PGAP1-like protein WD40 PF00400.30 MSTRG.26040.1_1 - 0.00047 20.8 0.0 3.3 8.6 0.0 3.9 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.26040.1_1 - 0.0023 18.1 0.0 1.7 8.8 0.0 3.9 4 1 2 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain CPSF_A PF03178.13 MSTRG.26040.1_1 - 0.0033 16.6 0.1 0.084 12.0 0.0 2.3 1 1 1 2 2 2 1 CPSF A subunit region AMP-binding PF00501.26 MSTRG.404.6_2 - 1.1e-109 366.8 0.0 1.3e-109 366.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme MFS_1 PF07690.14 MSTRG.18303.3_1 - 1e-56 192.3 26.2 1.9e-56 191.4 26.2 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.22 MSTRG.18303.3_1 - 3.5e-09 35.9 7.1 1.2e-08 34.1 7.0 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 MSTRG.18303.3_3 - 0.00013 20.9 0.4 0.0002 20.3 0.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily C1_1 PF00130.20 MSTRG.11128.2_2 - 1.2e-05 24.9 4.9 4.9e-05 23.0 4.9 2.1 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PH PF00169.27 MSTRG.11128.2_2 - 0.0007 19.9 0.9 1.2 9.6 0.1 2.9 3 0 0 3 3 3 2 PH domain Hydrolase_4 PF12146.6 MSTRG.22613.1_1 - 2.9e-07 29.9 0.4 1.6e-05 24.2 0.1 2.1 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.18 MSTRG.22613.1_1 - 1.4e-06 28.1 0.0 3e-06 26.9 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 MSTRG.22613.1_1 - 7.5e-06 26.6 0.2 1.8e-05 25.3 0.2 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.19 MSTRG.22613.1_1 - 0.00018 20.9 0.0 0.00029 20.2 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF2920 PF11144.6 MSTRG.22613.1_1 - 0.00065 18.8 0.0 0.0048 16.0 0.0 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF2920) SWIB PF02201.16 MSTRG.13308.1_1 - 2e-22 78.7 0.2 3.7e-22 77.8 0.2 1.5 1 0 0 1 1 1 1 SWIB/MDM2 domain TFIIA PF03153.11 MSTRG.13308.1_1 - 0.033 14.1 4.9 0.058 13.3 4.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.6 MSTRG.13308.1_1 - 0.07 11.9 4.8 0.11 11.3 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.6 MSTRG.13308.1_1 - 0.3 10.5 10.2 0.5 9.8 10.2 1.2 1 0 0 1 1 1 0 Spt20 family Lung_7-TM_R PF06814.11 MSTRG.630.1_3 - 1.1e-92 310.2 12.0 1.5e-92 309.8 12.0 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor GpcrRhopsn4 PF10192.7 MSTRG.630.1_3 - 0.22 10.8 13.5 0.11 11.8 10.4 1.8 1 1 1 2 2 2 0 Rhodopsin-like GPCR transmembrane domain DUF4381 PF14316.4 MSTRG.630.1_3 - 0.56 10.3 3.8 16 5.6 1.3 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4381) DUF3810 PF12725.5 MSTRG.630.1_3 - 1 8.5 4.2 0.5 9.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) Rab5ip PF07019.10 MSTRG.630.1_3 - 2.1 8.8 7.0 1.8 9.1 0.8 3.0 2 1 0 2 2 2 0 Rab5-interacting protein (Rab5ip) Pkinase PF00069.23 MSTRG.13576.1_2 - 4.9e-26 91.5 0.0 7e-26 91.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.13576.1_2 - 5.6e-09 35.5 0.0 8.8e-09 34.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.13576.1_2 - 0.075 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Pkinase PF00069.23 MSTRG.13576.1_3 - 2.8e-39 134.9 0.1 5.9e-39 133.9 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.13576.1_3 - 1e-16 60.9 0.2 1.5e-16 60.3 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase MAM PF00629.21 MSTRG.11951.18_3 - 3.3e-58 195.9 0.0 1.7e-33 115.6 0.0 2.2 2 0 0 2 2 2 2 MAM domain, meprin/A5/mu VWD PF00094.23 MSTRG.11951.18_3 - 2.6e-34 118.7 0.9 4.5e-34 117.9 0.9 1.4 1 0 0 1 1 1 1 von Willebrand factor type D domain C8 PF08742.9 MSTRG.11951.18_3 - 5.6e-18 65.0 1.4 5.6e-18 65.0 1.4 3.6 4 0 0 4 4 4 1 C8 domain TIL PF01826.15 MSTRG.11951.18_3 - 3.8e-12 46.1 14.9 3.8e-12 46.1 14.9 4.8 4 0 0 4 4 4 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.5 MSTRG.11951.18_3 - 1.7e-09 37.3 8.1 1.7e-09 37.3 8.1 3.1 2 1 1 3 3 3 1 TILa domain AdoHcyase_NAD PF00670.19 MSTRG.18461.1_1 - 9.1e-27 94.0 0.0 1.1e-26 93.7 0.0 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AdoHcyase PF05221.15 MSTRG.18461.1_1 - 3e-07 29.8 0.0 3e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase MIP-T3 PF10243.7 MSTRG.26548.1_2 - 0.066 11.8 38.8 0.082 11.5 38.8 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Rad60-SLD PF11976.6 MSTRG.1137.2_2 - 1.4e-24 85.5 0.1 2e-24 85.1 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.21 MSTRG.1137.2_2 - 1e-10 41.0 0.1 1.5e-10 40.5 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family RabGAP-TBC PF00566.16 MSTRG.14796.1_1 - 5.7e-50 169.8 0.5 1.1e-49 168.8 0.5 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF3350 PF11830.6 MSTRG.14796.1_1 - 3.1e-19 68.9 0.1 3.8e-18 65.4 0.0 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3350) PID PF00640.21 MSTRG.14796.1_1 - 1.9e-12 47.3 3.1 1.6e-05 24.9 0.3 3.3 3 0 0 3 3 3 2 Phosphotyrosine interaction domain (PTB/PID) zf-C4H2 PF10146.7 MSTRG.14796.1_1 - 0.14 12.3 8.2 0.032 14.4 3.5 2.3 2 0 0 2 2 2 0 Zinc finger-containing protein NDUF_B6 PF09782.7 MSTRG.14796.1_1 - 1.9 8.4 4.0 10 6.1 0.1 2.5 2 1 0 2 2 2 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit IncA PF04156.12 MSTRG.14796.1_1 - 3.5 7.2 15.7 0.07 12.8 6.6 2.5 2 0 0 2 2 2 0 IncA protein PTB PF08416.11 MSTRG.14796.1_1 - 4 7.5 8.7 0.11 12.5 0.4 2.7 4 0 0 4 4 4 0 Phosphotyrosine-binding domain CENP-H PF05837.10 MSTRG.14796.1_1 - 4.8 7.5 11.9 0.19 12.0 5.0 2.2 2 0 0 2 2 2 0 Centromere protein H (CENP-H) DUF2730 PF10805.6 MSTRG.14796.1_1 - 5.6 7.0 6.9 3.5 7.6 3.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) Cnn_1N PF07989.9 MSTRG.14796.1_1 - 6 6.9 12.7 0.18 11.8 4.4 2.8 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 DSPc PF00782.18 MSTRG.10433.1_2 - 1.5e-25 89.4 0.0 2.2e-25 88.9 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.10 MSTRG.10433.1_2 - 0.043 14.0 0.0 0.09 13.0 0.0 1.5 1 0 0 1 1 1 0 Rit1 DUSP-like domain NAPRTase PF04095.14 MSTRG.5178.3_2 - 3.6e-70 236.2 0.0 4.8e-70 235.8 0.0 1.1 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family HEAT PF02985.20 MSTRG.22535.1_2 - 0.0017 18.3 6.2 1.9 8.8 0.1 4.4 4 0 0 4 4 4 2 HEAT repeat Arm PF00514.21 MSTRG.22535.1_2 - 0.055 13.4 0.2 0.055 13.4 0.2 5.1 5 1 1 6 6 6 0 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.4 MSTRG.22535.1_2 - 0.06 13.7 4.7 0.66 10.4 0.3 4.5 4 1 1 5 5 5 0 HEAT-like repeat OB_NTP_bind PF07717.14 MSTRG.19651.3_3 - 1.3e-17 63.8 0.1 8.1e-17 61.2 0.0 2.2 1 1 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.21 MSTRG.19651.3_3 - 2.2e-16 60.0 0.8 6.1e-16 58.5 0.1 2.2 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.29 MSTRG.19651.3_3 - 4.3e-15 55.9 0.0 1.3e-14 54.4 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.27 MSTRG.19651.3_3 - 2e-10 40.6 0.0 4.1e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.4 MSTRG.19651.3_3 - 6.6e-05 23.1 0.1 0.00029 21.0 0.1 2.1 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.18 MSTRG.19651.3_3 - 0.0021 17.0 0.0 0.0054 15.7 0.0 1.6 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_19 PF13245.4 MSTRG.19651.3_3 - 0.02 15.1 0.0 0.063 13.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain ATPase PF06745.11 MSTRG.19651.3_3 - 0.031 13.5 0.0 0.077 12.2 0.0 1.6 1 0 0 1 1 1 0 KaiC AAA_16 PF13191.4 MSTRG.19651.3_3 - 0.061 13.6 0.6 0.51 10.6 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.4 MSTRG.19651.3_3 - 0.092 12.4 0.0 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.4 MSTRG.19651.3_3 - 0.098 13.0 4.5 1.2 9.4 0.0 2.4 1 1 1 2 2 2 0 AAA domain Lipoxygenase PF00305.17 MSTRG.2040.5_2 - 3e-62 210.9 0.1 1.1e-61 209.0 0.1 1.7 1 1 0 1 1 1 1 Lipoxygenase PLAT PF01477.21 MSTRG.2040.5_2 - 9.2e-13 48.7 0.0 1.8e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 PLAT/LH2 domain DSPc PF00782.18 MSTRG.7412.1_3 - 1.9e-47 160.3 0.0 2.9e-47 159.7 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.18 MSTRG.7412.1_3 - 1.9e-08 34.7 0.0 3e-06 27.6 0.0 2.3 2 0 0 2 2 2 2 Rhodanese-like domain Y_phosphatase PF00102.25 MSTRG.7412.1_3 - 8.3e-05 22.1 0.0 0.00013 21.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.10 MSTRG.7412.1_3 - 0.039 14.1 0.0 0.14 12.4 0.0 1.8 2 0 0 2 2 2 0 Rit1 DUSP-like domain GTP_EFTU PF00009.25 MSTRG.18658.2_2 - 1.1e-23 83.7 0.0 1.8e-23 83.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.23 MSTRG.18658.2_2 - 2.4e-06 27.7 0.2 2.4e-06 27.7 0.2 2.1 3 0 0 3 3 3 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.15 MSTRG.18658.2_2 - 0.0003 21.0 0.2 0.0014 18.7 0.2 2.1 1 1 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.21 MSTRG.18658.2_2 - 0.002 18.1 0.1 0.0052 16.7 0.1 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.7 MSTRG.18658.2_2 - 0.0088 15.7 0.3 5.4 6.6 0.0 3.5 3 1 1 4 4 4 1 Ethanolamine utilisation - propanediol utilisation Arf PF00025.19 MSTRG.18658.2_2 - 0.047 13.0 0.1 5.8 6.2 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family DUF258 PF03193.14 MSTRG.18658.2_2 - 0.14 11.9 0.1 15 5.3 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF258 LRR_9 PF14580.4 MSTRG.22301.1_3 - 2e-19 69.7 1.3 8.8e-15 54.5 0.0 2.6 1 1 1 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.5 MSTRG.22301.1_3 - 1.3e-14 53.9 22.7 5.4e-07 29.7 3.1 5.4 2 1 4 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 MSTRG.22301.1_3 - 3.6e-12 45.7 22.8 1.3e-06 27.9 2.4 4.2 2 2 2 4 4 4 3 Leucine rich repeat IQ PF00612.25 MSTRG.22301.1_3 - 0.0019 17.7 1.8 0.0046 16.5 1.8 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif LRR_6 PF13516.4 MSTRG.22301.1_3 - 0.63 10.1 12.7 0.52 10.4 0.9 4.8 6 0 0 6 6 6 0 Leucine Rich repeat LRR_1 PF00560.31 MSTRG.22301.1_3 - 0.76 10.3 10.4 3.6 8.3 0.1 5.5 6 0 0 6 6 6 0 Leucine Rich Repeat Arf PF00025.19 MSTRG.20140.2_3 - 3.7e-43 146.9 0.0 5.4e-43 146.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 MSTRG.20140.2_3 - 2.9e-08 33.9 0.0 5.8e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 MSTRG.20140.2_3 - 3.5e-08 33.0 0.0 6.9e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.20 MSTRG.20140.2_3 - 4.3e-08 32.8 0.0 7.2e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 Ras family G-alpha PF00503.18 MSTRG.20140.2_3 - 4.5e-07 29.2 0.5 0.00038 19.6 0.0 3.1 2 1 1 3 3 3 2 G-protein alpha subunit MMR_HSR1 PF01926.21 MSTRG.20140.2_3 - 1.7e-05 24.7 0.0 3.5e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase BUD22 PF09073.8 MSTRG.20140.2_3 - 0.031 13.5 15.4 0.041 13.1 15.4 1.1 1 0 0 1 1 1 0 BUD22 SH2 PF00017.22 MSTRG.27724.1_2 - 6.4e-07 29.2 0.0 1.4e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 SH2 domain DUF3456 PF11938.6 MSTRG.3342.1_2 - 4.7e-46 157.0 1.9 4.7e-46 157.0 1.9 2.2 2 0 0 2 2 2 1 TLR4 regulator and MIR-interacting MSAP Sarcoglycan_2 PF05510.11 MSTRG.6810.2_3 - 3.9e-112 374.7 0.0 5.5e-112 374.2 0.0 1.1 1 0 0 1 1 1 1 Sarcoglycan alpha/epsilon Oxysterol_BP PF01237.16 MSTRG.20643.1_1 - 1.7e-94 316.6 4.0 4.3e-92 308.7 4.0 2.3 1 1 0 1 1 1 1 Oxysterol-binding protein PH PF00169.27 MSTRG.20643.1_1 - 3.7e-09 36.9 0.4 2.4e-08 34.3 0.1 2.6 2 0 0 2 2 2 1 PH domain TNRC6-PABC_bdg PF16608.3 MSTRG.431.1_3 - 3.7e-60 204.0 25.9 3.7e-60 204.0 25.9 6.9 7 1 0 8 8 8 1 TNRC6-PABC binding domain RRM_1 PF00076.20 MSTRG.431.1_3 - 0.0055 16.4 0.0 0.0099 15.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 MSTRG.431.1_3 - 0.0083 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif MAP65_ASE1 PF03999.10 MSTRG.431.1_3 - 3.2 6.2 11.3 5.6 5.4 11.3 1.3 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) HTH_32 PF13565.4 MSTRG.431.1_3 - 7.2 7.2 6.4 2.5 8.6 0.1 2.9 3 0 0 3 3 3 0 Homeodomain-like domain GPS PF01825.19 MSTRG.16382.1_1 - 3.6e-13 49.8 1.0 7.9e-13 48.7 1.0 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif HRM PF02793.20 MSTRG.16382.1_1 - 0.03 14.5 0.5 0.052 13.7 0.5 1.3 1 0 0 1 1 1 0 Hormone receptor domain Inositol_P PF00459.23 MSTRG.7055.1_1 - 9e-36 123.6 0.1 1.5e-35 122.9 0.1 1.3 1 0 0 1 1 1 1 Inositol monophosphatase family Tmemb_cc2 PF10267.7 MSTRG.13972.1_1 - 1.9e-37 129.3 10.9 2e-37 129.2 10.9 1.0 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein Spc7 PF08317.9 MSTRG.13972.1_1 - 0.0032 16.3 5.9 0.0036 16.1 5.9 1.0 1 0 0 1 1 1 1 Spc7 kinetochore protein HMMR_N PF15905.3 MSTRG.13972.1_1 - 0.0043 16.5 7.0 0.0045 16.4 7.0 1.0 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal CortBP2 PF09727.7 MSTRG.13972.1_1 - 0.0048 16.7 8.9 0.0049 16.7 8.9 1.0 1 0 0 1 1 1 1 Cortactin-binding protein-2 DUF713 PF05218.12 MSTRG.13972.1_1 - 0.0058 16.3 1.5 0.0074 15.9 1.1 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF713) Golgin_A5 PF09787.7 MSTRG.13972.1_1 - 0.012 15.0 7.2 0.013 14.8 7.2 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF3450 PF11932.6 MSTRG.13972.1_1 - 0.018 14.2 4.3 0.023 13.9 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) PRKG1_interact PF15898.3 MSTRG.13972.1_1 - 0.023 15.4 5.7 0.029 15.1 5.7 1.1 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DUF745 PF05335.11 MSTRG.13972.1_1 - 0.025 14.2 1.2 0.038 13.6 1.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF745) Sipho_Gp157 PF05565.9 MSTRG.13972.1_1 - 0.034 14.0 3.2 0.042 13.7 3.2 1.1 1 0 0 1 1 1 0 Siphovirus Gp157 Mnd1 PF03962.13 MSTRG.13972.1_1 - 0.035 13.8 5.1 0.042 13.6 5.1 1.0 1 0 0 1 1 1 0 Mnd1 family Baculo_PEP_C PF04513.10 MSTRG.13972.1_1 - 0.041 13.8 0.1 0.055 13.4 0.1 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Snapin_Pallidin PF14712.4 MSTRG.13972.1_1 - 0.046 14.0 7.1 1.6 9.1 7.1 2.1 1 1 0 1 1 1 0 Snapin/Pallidin Reo_sigmaC PF04582.10 MSTRG.13972.1_1 - 0.049 12.9 0.3 0.058 12.6 0.3 1.0 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Tweety PF04906.11 MSTRG.13972.1_1 - 0.055 12.0 0.6 0.068 11.7 0.6 1.0 1 0 0 1 1 1 0 Tweety LXG PF04740.10 MSTRG.13972.1_1 - 0.068 12.7 6.6 0.61 9.6 6.8 1.7 1 1 1 2 2 2 0 LXG domain of WXG superfamily TMPIT PF07851.11 MSTRG.13972.1_1 - 0.082 12.0 5.3 0.097 11.8 5.3 1.0 1 0 0 1 1 1 0 TMPIT-like protein DUF1664 PF07889.10 MSTRG.13972.1_1 - 0.13 12.1 2.4 0.2 11.5 2.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) XkdW PF09636.8 MSTRG.13972.1_1 - 0.15 12.0 2.4 0.18 11.8 2.4 1.2 1 0 0 1 1 1 0 XkdW protein Exonuc_VII_L PF02601.13 MSTRG.13972.1_1 - 0.17 11.2 4.3 0.18 11.2 4.3 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit DASH_Dad2 PF08654.8 MSTRG.13972.1_1 - 0.2 12.0 3.9 5.7 7.3 1.4 2.1 2 0 0 2 2 2 0 DASH complex subunit Dad2 SlyX PF04102.10 MSTRG.13972.1_1 - 0.22 12.0 8.1 54 4.4 8.1 2.4 1 1 0 1 1 1 0 SlyX THOC7 PF05615.11 MSTRG.13972.1_1 - 0.26 11.4 9.0 0.56 10.4 4.3 2.0 1 1 1 2 2 2 0 Tho complex subunit 7 Phage_Mu_Gam PF07352.10 MSTRG.13972.1_1 - 0.28 10.9 5.0 2 8.2 0.2 2.0 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein FlaC_arch PF05377.9 MSTRG.13972.1_1 - 0.31 11.3 4.1 17 5.7 1.9 2.4 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) OmpH PF03938.12 MSTRG.13972.1_1 - 0.44 10.4 8.9 0.72 9.7 8.9 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) CREPT PF16566.3 MSTRG.13972.1_1 - 0.45 10.5 8.1 0.6 10.1 8.1 1.3 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour IncA PF04156.12 MSTRG.13972.1_1 - 2.4 7.7 9.6 25 4.4 9.5 1.9 1 1 1 2 2 2 0 IncA protein Ank_2 PF12796.5 MSTRG.5217.1_1 - 3.7e-72 238.8 19.2 1.5e-11 44.5 0.0 7.9 1 1 4 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.5217.1_1 - 4.4e-58 192.8 21.8 5.9e-09 36.2 0.2 11.3 6 2 5 12 12 12 11 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.5217.1_1 - 4.8e-51 164.6 23.7 0.00065 19.8 0.0 15.3 16 0 0 16 16 16 12 Ankyrin repeat Ank PF00023.28 MSTRG.5217.1_1 - 7.7e-51 168.3 37.6 2.3e-06 27.7 0.0 14.5 16 0 0 16 16 16 12 Ankyrin repeat Ank_5 PF13857.4 MSTRG.5217.1_1 - 2.4e-47 158.1 32.6 1.2e-06 28.5 0.7 14.0 3 2 11 14 14 14 14 Ankyrin repeats (many copies) BAR PF03114.16 MSTRG.20924.2_3 - 7.1e-67 225.4 4.1 1.1e-66 224.8 4.1 1.2 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.4 MSTRG.20924.2_3 - 5.6e-10 38.8 0.1 1.3e-09 37.7 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.20924.2_3 - 6.5e-07 28.7 0.0 1.1e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 SH3 domain BAR_2 PF10455.7 MSTRG.20924.2_3 - 3.5e-06 26.2 1.5 6.1e-06 25.4 1.5 1.4 1 1 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking SH3_2 PF07653.15 MSTRG.20924.2_3 - 8.2e-05 22.1 0.0 0.00014 21.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain BAR_3 PF16746.3 MSTRG.20924.2_3 - 0.01 15.4 1.5 3.3 7.2 0.0 2.3 1 1 1 2 2 2 2 BAR domain of APPL family zf-RING_11 PF17123.3 MSTRG.20924.2_3 - 0.2 11.3 1.3 0.52 9.9 1.3 1.7 1 0 0 1 1 1 0 RING-like zinc finger NPR3 PF03666.11 MSTRG.5254.1_1 - 3.4e-07 29.3 0.0 5e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 Spectrin PF00435.19 MSTRG.1225.1_3 - 0.13 12.6 3.3 0.14 12.6 0.1 2.5 2 1 0 2 2 2 0 Spectrin repeat RAM PF15320.4 MSTRG.17468.2_3 - 9.3e-21 74.1 26.7 7.1e-19 68.1 13.6 2.8 2 1 1 3 3 3 2 mRNA cap methylation, RNMT-activating mini protein EGF_CA PF07645.13 MSTRG.13517.1_1 - 2.2e-60 200.5 134.0 2e-10 40.5 6.8 9.5 9 0 0 9 9 9 8 Calcium-binding EGF domain cEGF PF12662.5 MSTRG.13517.1_1 - 8.9e-36 121.3 78.6 2.1e-09 37.0 1.7 10.5 10 0 0 10 10 10 7 Complement Clr-like EGF-like FXa_inhibition PF14670.4 MSTRG.13517.1_1 - 2.3e-21 75.6 133.3 1e-08 35.2 8.4 9.9 7 2 3 10 10 10 6 Coagulation Factor Xa inhibitory site EGF PF00008.25 MSTRG.13517.1_1 - 3.2e-20 71.9 120.2 0.00099 19.2 4.9 10.1 8 2 1 9 9 9 8 EGF-like domain TB PF00683.15 MSTRG.13517.1_1 - 2.5e-14 52.6 9.0 2e-13 49.6 9.0 2.8 1 0 0 1 1 1 1 TB domain EGF_3 PF12947.5 MSTRG.13517.1_1 - 5.7e-13 48.7 115.7 1.1e-05 25.3 5.1 10.7 7 2 2 9 9 9 6 EGF domain hEGF PF12661.5 MSTRG.13517.1_1 - 2.9e-11 43.4 117.8 0.00032 21.1 6.8 11.5 11 0 0 11 11 11 6 Human growth factor-like EGF GAS PF13851.4 MSTRG.24805.1_2 - 0.00032 20.0 32.7 0.00032 20.0 32.7 2.9 1 1 2 3 3 3 1 Growth-arrest specific micro-tubule binding Reo_sigmaC PF04582.10 MSTRG.24805.1_2 - 0.00097 18.5 5.1 0.0018 17.6 1.5 2.1 1 1 1 2 2 2 1 Reovirus sigma C capsid protein Spc7 PF08317.9 MSTRG.24805.1_2 - 0.012 14.4 51.8 0.42 9.3 12.4 3.0 1 1 2 3 3 3 0 Spc7 kinetochore protein DUF1664 PF07889.10 MSTRG.24805.1_2 - 0.43 10.5 29.0 0.063 13.1 3.0 3.9 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) CSTF2_hinge PF14327.4 MSTRG.24805.1_2 - 0.48 10.8 3.6 4.5 7.7 0.2 2.8 2 1 0 2 2 2 0 Hinge domain of cleavage stimulation factor subunit 2 FAM184 PF15665.3 MSTRG.24805.1_2 - 0.96 9.1 50.4 0.14 11.8 7.3 3.1 1 1 2 3 3 3 0 Family with sequence similarity 184, A and B Tropomyosin PF00261.18 MSTRG.24805.1_2 - 2.7 7.2 53.2 4.5 6.4 52.4 1.7 1 1 0 1 1 1 0 Tropomyosin Lectin_N PF03954.12 MSTRG.24805.1_2 - 4 7.1 21.5 0.49 10.0 0.3 3.7 2 2 1 3 3 3 0 Hepatic lectin, N-terminal domain TPR_MLP1_2 PF07926.10 MSTRG.24805.1_2 - 7.2 6.6 56.7 0.31 11.0 22.3 4.1 1 1 3 4 4 4 0 TPR/MLP1/MLP2-like protein ERM PF00769.17 MSTRG.24805.1_2 - 7.6 6.1 58.9 4.7 6.8 42.8 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF16 PF01519.14 MSTRG.24805.1_2 - 8.3 6.8 38.2 1.2 9.6 0.9 5.0 1 1 2 3 3 2 0 Protein of unknown function DUF16 Glyco_transf_25 PF01755.15 MSTRG.8626.1_1 - 1.4e-31 109.8 0.0 5.2e-31 107.9 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Glyco_tranf_2_4 PF13704.4 MSTRG.8626.1_1 - 7.6e-13 48.7 0.3 1.5e-12 47.7 0.3 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Anp1 PF03452.12 MSTRG.8626.1_1 - 0.0002 20.7 0.0 0.0012 18.2 0.0 1.9 1 1 0 1 1 1 1 Anp1 Glyco_transf_64 PF09258.8 MSTRG.15063.1_3 - 6.1e-17 61.6 0.1 7.3e-17 61.4 0.1 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Trypsin PF00089.24 MSTRG.20097.1_1 - 3.8e-20 72.5 0.0 6.3e-20 71.8 0.0 1.4 1 0 0 1 1 1 1 Trypsin Gla PF00594.18 MSTRG.20097.1_1 - 5.8e-18 64.7 9.1 1e-17 63.9 9.1 1.4 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FXa_inhibition PF14670.4 MSTRG.20097.1_1 - 1.6e-06 28.1 7.4 1.6e-06 28.1 7.4 4.7 6 0 0 6 6 6 2 Coagulation Factor Xa inhibitory site cEGF PF12662.5 MSTRG.20097.1_1 - 0.00013 21.7 0.8 0.00013 21.7 0.8 2.8 2 0 0 2 2 2 1 Complement Clr-like EGF-like EGF PF00008.25 MSTRG.20097.1_1 - 0.0017 18.4 12.1 0.0017 18.4 12.1 4.0 5 0 0 5 5 5 2 EGF-like domain DUF1986 PF09342.9 MSTRG.20097.1_1 - 0.012 15.8 0.0 0.023 14.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) EGF_CA PF07645.13 MSTRG.20097.1_1 - 0.19 11.8 20.4 1.7 8.8 6.2 3.0 2 0 0 2 2 2 0 Calcium-binding EGF domain Arc_PepC_II PF06847.9 MSTRG.11501.2_3 - 0.012 16.0 0.3 0.035 14.5 0.3 1.7 1 0 0 1 1 1 0 Archaeal Peptidase A24 C-terminus Type II Atrophin-1 PF03154.13 MSTRG.22806.1_1 - 2.8 6.0 13.7 3.8 5.5 13.7 1.1 1 0 0 1 1 1 0 Atrophin-1 family P2X_receptor PF00864.17 MSTRG.22806.1_2 - 2.9e-146 487.1 0.3 4.1e-146 486.6 0.3 1.2 1 0 0 1 1 1 1 ATP P2X receptor Sortilin-Vps10 PF15902.3 MSTRG.25986.1_3 - 4.2e-107 358.6 1.5 7e-107 357.9 1.5 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.3 MSTRG.25986.1_3 - 2.5e-38 132.0 8.2 2.5e-38 132.0 8.2 1.5 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, C-terminal PKD PF00801.18 MSTRG.25986.1_3 - 1.4e-10 40.8 0.8 4.9e-06 26.2 0.0 2.6 2 0 0 2 2 2 2 PKD domain BNR_6 PF15899.3 MSTRG.25986.1_3 - 0.00073 19.2 0.1 1.9 8.7 0.0 4.0 3 0 0 3 3 3 2 BNR-Asp box repeat BNR PF02012.18 MSTRG.25986.1_3 - 0.024 14.5 16.1 19 5.6 0.1 6.5 6 0 0 6 6 6 0 BNR/Asp-box repeat Pkinase PF00069.23 MSTRG.4921.3_1 - 2.6e-68 230.1 0.0 3.8e-68 229.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 MSTRG.4921.3_1 - 4e-38 129.3 0.0 5.7e-22 77.5 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Pkinase_Tyr PF07714.15 MSTRG.4921.3_1 - 1.8e-34 119.1 0.0 2.6e-34 118.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.4 MSTRG.4921.3_1 - 1.3e-23 83.2 0.0 4.3e-13 49.5 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.4921.3_1 - 2.3e-17 63.0 0.6 1.2e-08 35.0 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.23 MSTRG.4921.3_1 - 1.7e-14 53.6 0.0 7.1e-08 32.4 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain fn3 PF00041.19 MSTRG.4921.3_1 - 1.2e-11 44.6 0.1 2.4e-11 43.7 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III domain V-set PF07686.15 MSTRG.4921.3_1 - 2.8e-09 37.0 0.6 0.0051 16.8 0.1 4.2 2 2 0 2 2 2 2 Immunoglobulin V-set domain RIO1 PF01163.20 MSTRG.4921.3_1 - 0.00015 21.3 0.0 0.00028 20.4 0.0 1.3 1 0 0 1 1 1 1 RIO1 family C2-set_2 PF08205.10 MSTRG.4921.3_1 - 0.023 14.6 0.0 0.077 12.9 0.0 1.9 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain FTA2 PF13095.4 MSTRG.4921.3_1 - 0.054 13.0 0.3 2.1 7.8 0.0 2.5 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Y_Y_Y PF07495.11 MSTRG.4921.3_1 - 0.11 12.3 0.0 0.26 11.1 0.0 1.6 1 0 0 1 1 1 0 Y_Y_Y domain P4Ha_N PF08336.9 MSTRG.9515.2_1 - 1.2e-39 135.3 0.2 2.3e-39 134.4 0.2 1.5 1 0 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 2OG-FeII_Oxy_3 PF13640.4 MSTRG.9515.2_1 - 3e-16 59.9 0.0 7.7e-16 58.6 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TPR_2 PF07719.15 MSTRG.9515.2_1 - 0.0019 18.0 0.0 0.22 11.6 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat SPO22 PF08631.8 MSTRG.9515.2_1 - 0.041 13.2 0.0 0.069 12.5 0.0 1.2 1 0 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like Mito_carr PF00153.25 MSTRG.9415.1_3 - 1.3e-66 220.4 2.0 9.5e-25 86.2 0.1 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein HLH PF00010.24 MSTRG.13075.1_3 - 3.2e-11 42.9 1.1 7.6e-11 41.7 1.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.11 MSTRG.13075.1_3 - 5.7e-07 29.5 0.1 1.9e-06 27.9 0.1 1.9 2 0 0 2 2 2 1 Hairy Orange Ad_cyc_g-alpha PF08509.9 MSTRG.13075.1_3 - 0.049 13.3 0.0 0.098 12.3 0.0 1.5 1 0 0 1 1 1 0 Adenylate cyclase G-alpha binding domain DUF2678 PF10856.6 MSTRG.24274.3_2 - 1.7e-66 221.3 0.5 2.7e-66 220.7 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2678) Vinculin PF01044.17 MSTRG.23244.1_1 - 5.1e-18 64.6 0.1 6.1e-18 64.4 0.1 1.0 1 0 0 1 1 1 1 Vinculin family I-set PF07679.14 MSTRG.11875.1_2 - 1.8e-16 59.8 0.0 2.8e-16 59.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.11875.1_2 - 1e-12 48.4 0.0 1.8e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.11875.1_2 - 1.5e-06 28.3 0.0 2.7e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 MSTRG.11875.1_2 - 7.2e-05 22.8 0.0 0.00032 20.7 0.0 1.9 1 1 1 2 2 2 1 Immunoglobulin V-set domain ig PF00047.23 MSTRG.11875.1_2 - 0.00012 22.0 0.0 0.00024 21.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain OAD_gamma PF04277.11 MSTRG.11875.1_3 - 0.14 12.6 0.0 0.24 11.9 0.0 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Frag1 PF10277.7 MSTRG.25380.1_3 - 2.7e-41 141.4 18.5 3.5e-41 141.0 18.5 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Sulfate_transp PF00916.18 MSTRG.20314.1_1 - 3e-15 55.7 2.9 3.9e-15 55.4 2.9 1.1 1 0 0 1 1 1 1 Sulfate permease family Sec3_C PF09763.7 MSTRG.19610.2_1 - 0.075 11.3 0.2 0.11 10.7 0.2 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 Sarcoglycan_2 PF05510.11 MSTRG.4837.3_1 - 2.8e-51 174.3 0.0 1.2e-50 172.3 0.0 1.7 1 1 0 1 1 1 1 Sarcoglycan alpha/epsilon DUF3377 PF11857.6 MSTRG.4837.3_1 - 0.084 12.7 0.1 0.2 11.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) DAG1 PF05454.9 MSTRG.4837.3_1 - 0.22 10.7 1.1 0.68 9.1 1.1 1.7 1 1 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) Kringle PF00051.16 MSTRG.3049.1_3 - 1.3e-16 60.5 2.8 2.5e-16 59.6 2.8 1.5 1 0 0 1 1 1 1 Kringle domain Peptidase_M28 PF04389.15 MSTRG.6235.1_2 - 5.5e-46 156.6 0.0 8.7e-46 156.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.26 MSTRG.6235.1_2 - 0.00019 21.1 0.0 0.00042 20.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.12 MSTRG.6235.1_2 - 0.084 11.7 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 M42 glutamyl aminopeptidase SERTA PF06031.11 MSTRG.27075.1_2 - 3.9e-13 48.7 0.1 7.8e-13 47.7 0.1 1.5 1 0 0 1 1 1 1 SERTA motif Ank_2 PF12796.5 MSTRG.20021.1_2 - 4.1e-22 78.4 0.8 2.6e-08 34.2 0.2 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.28 MSTRG.20021.1_2 - 9.9e-19 66.8 7.3 8.8e-05 22.7 0.4 6.2 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.4 MSTRG.20021.1_2 - 3.6e-16 57.5 1.7 0.01 16.1 0.1 6.9 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.4 MSTRG.20021.1_2 - 5e-16 58.7 0.9 3.8e-05 24.0 0.0 5.5 5 0 0 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 MSTRG.20021.1_2 - 7.3e-16 57.9 6.9 2.4e-06 27.6 0.1 5.4 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Thx PF17070.3 MSTRG.7342.2_1 - 2.3 8.3 8.5 6.2 7.0 8.5 1.7 1 0 0 1 1 1 0 30S ribosomal protein Thx CC2-LZ PF16516.3 MSTRG.7342.2_2 - 7.5e-13 48.6 14.0 7.5e-13 48.6 14.0 4.9 3 2 2 5 5 5 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF3138 PF11336.6 MSTRG.7342.2_2 - 0.96 7.9 6.3 0.21 10.0 1.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) SATase_N PF06426.12 MSTRG.7342.2_2 - 2.9 8.2 6.5 1.9 8.8 0.1 3.3 3 1 0 3 3 3 0 Serine acetyltransferase, N-terminal Pentaxin PF00354.15 MSTRG.6863.3_2 - 1e-32 113.3 0.0 1.4e-32 112.9 0.0 1.1 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.4 MSTRG.6863.3_2 - 1.9e-13 50.7 0.0 2.7e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily FlxA PF14282.4 MSTRG.6863.3_2 - 0.00017 21.4 0.2 0.00026 20.8 0.2 1.2 1 0 0 1 1 1 1 FlxA-like protein Laminin_G_2 PF02210.22 MSTRG.6863.3_2 - 0.00056 20.4 0.1 0.0016 18.9 0.1 1.7 1 1 0 1 1 1 1 Laminin G domain Tropomyosin_1 PF12718.5 MSTRG.6863.3_2 - 0.022 14.7 0.9 0.039 13.9 0.9 1.3 1 0 0 1 1 1 0 Tropomyosin like Lectin_N PF03954.12 MSTRG.6863.3_2 - 0.063 12.9 1.5 0.11 12.1 1.5 1.3 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain Myosin_tail_1 PF01576.17 MSTRG.6863.3_2 - 0.079 10.6 2.0 0.1 10.2 2.0 1.0 1 0 0 1 1 1 0 Myosin tail Toxin_8 PF07365.10 MSTRG.6863.3_2 - 0.1 12.7 0.4 0.2 11.7 0.4 1.5 1 0 0 1 1 1 0 Alpha conotoxin precursor CLZ PF16526.3 MSTRG.6863.3_2 - 0.32 11.2 6.4 0.11 12.7 3.5 1.7 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels NEMO PF11577.6 MSTRG.6863.3_2 - 0.49 10.3 4.1 0.85 9.5 4.1 1.3 1 0 0 1 1 1 0 NF-kappa-B essential modulator NEMO C1-set PF07654.13 MSTRG.1025.2_2 - 5.4e-24 84.3 0.1 1e-23 83.5 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_II_beta PF00969.17 MSTRG.1025.2_2 - 2.9e-12 46.4 0.5 4.9e-12 45.7 0.5 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C2-set_2 PF08205.10 MSTRG.1025.2_2 - 7e-06 25.9 0.0 1.4e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 MSTRG.1025.2_2 - 0.00021 21.7 0.1 0.00064 20.2 0.1 1.9 1 1 0 1 1 1 1 Immunoglobulin domain CAP_GLY PF01302.23 MSTRG.19920.1_3 - 3.8e-22 77.9 2.0 5.8e-22 77.4 2.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain HNOBA PF07701.12 MSTRG.27778.1_3 - 3.9e-56 189.8 0.0 5.7e-56 189.2 0.0 1.3 1 0 0 1 1 1 1 Heme NO binding associated HNOB PF07700.13 MSTRG.27778.1_3 - 2.3e-55 186.9 0.1 3.2e-55 186.4 0.1 1.2 1 0 0 1 1 1 1 Haem-NO-binding Guanylate_cyc PF00211.18 MSTRG.27778.1_3 - 9.9e-12 44.7 0.0 1.7e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Cobl PF09469.8 MSTRG.6342.1_3 - 2.9e-32 110.7 0.4 3.6e-31 107.1 0.1 2.2 2 0 0 2 2 2 1 Cordon-bleu ubiquitin-like domain RBD PF02196.13 MSTRG.6342.1_3 - 1.8e-05 24.6 0.2 7.1e-05 22.7 0.1 2.0 2 0 0 2 2 2 1 Raf-like Ras-binding domain TUG-UBL1 PF11470.6 MSTRG.6342.1_3 - 0.02 15.0 0.3 3.5 7.8 0.0 3.0 3 0 0 3 3 3 0 TUG ubiquitin-like domain fn3 PF00041.19 MSTRG.24447.6_1 - 1.1e-77 256.3 0.2 5.6e-14 52.1 0.0 6.8 6 0 0 6 6 6 5 Fibronectin type III domain I-set PF07679.14 MSTRG.24447.6_1 - 1.2e-69 230.2 14.8 6.1e-19 67.7 0.0 8.5 9 0 0 9 9 9 7 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.24447.6_1 - 4.4e-47 158.4 7.8 4.3e-11 43.1 0.0 7.9 8 0 0 8 8 8 5 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.24447.6_1 - 3e-30 104.3 8.8 1.3e-06 28.5 0.0 6.7 6 0 0 6 6 6 5 Immunoglobulin domain ig PF00047.23 MSTRG.24447.6_1 - 9.9e-25 86.4 14.1 9.9e-07 28.7 0.1 7.1 7 0 0 7 7 7 5 Immunoglobulin domain V-set PF07686.15 MSTRG.24447.6_1 - 8.8e-17 61.1 21.3 0.0035 17.3 0.1 9.6 6 4 1 7 7 7 5 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.3 MSTRG.24447.6_1 - 4.9e-15 55.7 0.0 0.015 15.7 0.1 6.6 5 0 0 5 5 5 4 Purple acid Phosphatase, N-terminal domain Tissue_fac PF01108.15 MSTRG.24447.6_1 - 1.3e-07 31.2 0.1 0.018 14.7 0.0 4.9 6 0 0 6 6 6 2 Tissue factor C2-set_2 PF08205.10 MSTRG.24447.6_1 - 8.5e-07 28.8 2.0 0.073 13.0 0.0 4.3 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Adeno_E3_CR1 PF02440.13 MSTRG.24447.6_1 - 0.00035 20.1 1.3 0.33 10.6 0.1 3.9 3 0 0 3 3 3 1 Adenovirus E3 region protein CR1 C1-set PF07654.13 MSTRG.24447.6_1 - 0.0028 18.0 4.7 1.1 9.7 0.2 4.3 4 0 0 4 4 4 1 Immunoglobulin C1-set domain RRM_1 PF00076.20 MSTRG.23560.1_3 - 7.6e-22 76.8 0.0 1e-21 76.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 MSTRG.23560.1_3 - 2.3e-06 27.1 0.0 3e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Neuralized PF07177.10 MSTRG.20578.1_1 - 2.8e-67 225.3 0.0 3.3e-41 140.6 0.0 2.2 2 0 0 2 2 2 2 Neuralized zf-C3HC4_3 PF13920.4 MSTRG.20578.1_1 - 1e-13 50.8 11.2 3.5e-13 49.0 11.2 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 MSTRG.20578.1_1 - 0.00021 20.9 11.5 0.00058 19.5 11.5 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.4 MSTRG.20578.1_1 - 0.00048 20.2 12.1 0.00048 20.2 12.1 2.4 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.4 MSTRG.20578.1_1 - 0.13 12.1 12.8 0.42 10.5 12.8 2.0 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.4 MSTRG.20578.1_1 - 3.6 7.4 21.2 0.29 10.9 14.8 2.6 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Spt20 PF12090.6 MSTRG.912.3_2 - 1e-35 123.3 19.7 5.8e-18 65.2 0.0 3.2 2 1 1 3 3 3 2 Spt20 family 7tm_1 PF00001.19 MSTRG.5778.1_1 - 2.1e-33 115.5 7.1 2.3e-33 115.4 7.1 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 MSTRG.5778.1_1 - 5.9e-05 22.4 6.0 7.3e-05 22.1 6.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.7 MSTRG.5778.1_1 - 0.00048 19.4 2.5 0.00057 19.2 2.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 MSTRG.5778.1_1 - 0.00088 18.9 2.1 0.0016 18.1 2.1 1.5 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srv PF10323.7 MSTRG.5778.1_1 - 0.0054 16.0 3.4 0.0097 15.1 3.4 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Atrophin-1 PF03154.13 MSTRG.16571.1_1 - 0.44 8.6 6.0 0.6 8.2 6.0 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.4 MSTRG.16571.1_2 - 0.46 10.3 2.7 0.83 9.5 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 MSTRG.16571.1_2 - 1.5 6.9 8.6 2 6.5 8.6 1.0 1 0 0 1 1 1 0 Atrophin-1 family WD40 PF00400.30 MSTRG.1334.1_1 - 1.5e-25 88.8 9.1 6.5e-07 29.8 0.2 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.1334.1_1 - 7.1e-06 26.1 0.3 0.33 11.1 0.0 4.2 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 MSTRG.1334.1_1 - 0.00047 18.8 0.0 0.041 12.4 0.0 2.1 2 0 0 2 2 2 2 Nucleoporin Nup120/160 Sugar_tr PF00083.22 MSTRG.9469.1_3 - 4.2e-29 101.6 20.1 6.9e-29 100.9 20.1 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 MSTRG.9469.1_3 - 2.6e-23 82.4 45.1 1.5e-21 76.6 27.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Ras PF00071.20 MSTRG.6421.2_2 - 1.5e-58 196.9 0.1 2.2e-58 196.3 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.6421.2_2 - 1.3e-31 109.2 0.1 2.1e-31 108.5 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.6421.2_2 - 5.9e-14 51.8 0.1 9.5e-14 51.1 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 MSTRG.6421.2_2 - 0.00018 20.8 0.0 0.00026 20.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 MSTRG.6421.2_2 - 0.007 16.3 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 MSTRG.6421.2_2 - 0.0076 15.6 0.3 0.095 12.1 0.3 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.8 MSTRG.6421.2_2 - 0.11 11.8 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF974 PF06159.11 MSTRG.17644.1_3 - 9.9e-85 284.1 0.7 1.4e-84 283.6 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF974) Trs65 PF12735.5 MSTRG.17644.1_3 - 0.0024 17.2 0.0 0.86 8.8 0.0 3.1 2 1 0 3 3 3 1 TRAPP trafficking subunit Trs65 Ank_4 PF13637.4 MSTRG.11420.2_2 - 2e-22 79.1 8.6 3.9e-13 49.5 0.1 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 MSTRG.11420.2_2 - 1.4e-18 67.1 2.0 2.4e-15 56.8 0.9 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 MSTRG.11420.2_2 - 3.9e-17 61.7 11.5 1.1e-08 35.0 0.2 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.4 MSTRG.11420.2_2 - 5.6e-15 55.1 12.1 3.8e-08 33.4 0.9 3.4 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.11420.2_2 - 2.3e-14 51.9 5.8 4.5e-06 26.4 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat MnmE_helical PF12631.5 MSTRG.14217.1_2 - 0.006 16.6 0.2 0.0064 16.5 0.2 1.0 1 0 0 1 1 1 1 MnmE helical domain DUF4221 PF13970.4 MSTRG.14217.1_2 - 0.1 12.0 0.0 0.11 11.9 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4221) MRVI1 PF05781.10 MSTRG.23500.5_2 - 4.9e-85 286.1 21.0 1.3e-84 284.8 9.3 3.0 2 1 0 2 2 2 1 MRVI1 protein DUF919 PF06034.9 MSTRG.23500.5_2 - 0.18 11.5 2.1 0.17 11.6 0.5 1.8 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) DUF3040 PF11239.6 MSTRG.23500.5_2 - 0.78 9.9 4.0 0.38 10.9 1.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) MCM PF00493.21 MSTRG.21777.3_2 - 1.1e-133 445.3 0.0 1.5e-133 444.9 0.0 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_OB PF17207.1 MSTRG.21777.3_2 - 7.1e-39 132.4 1.6 1.3e-38 131.6 1.6 1.4 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.19 MSTRG.21777.3_2 - 8e-07 28.5 0.0 0.00024 20.4 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.12 MSTRG.21777.3_2 - 0.0012 18.7 0.2 0.0089 15.9 0.1 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.24 MSTRG.21777.3_2 - 0.024 14.2 0.0 0.22 11.1 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_3 PF07726.9 MSTRG.21777.3_2 - 0.032 14.0 0.0 0.11 12.2 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PH_12 PF16457.3 MSTRG.18396.2_1 - 1.9e-39 135.1 0.2 3.3e-39 134.3 0.0 1.5 2 0 0 2 2 2 1 Pleckstrin homology domain ZFYVE21_C PF16696.3 MSTRG.18396.2_1 - 0.0016 18.1 0.0 0.0027 17.4 0.0 1.4 1 0 0 1 1 1 1 Zinc finger FYVE domain-containing protein 21 C-terminus DEAD PF00270.27 MSTRG.7994.1_1 - 4.1e-49 166.6 0.2 6.1e-49 166.0 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.7994.1_1 - 2.3e-32 111.6 0.1 2.9e-31 108.0 0.0 2.6 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.7994.1_1 - 6.2e-07 29.4 0.0 1.2e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.3 MSTRG.7994.1_1 - 7.8e-07 28.4 1.3 8e-07 28.4 0.0 1.6 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase Flavi_DEAD PF07652.12 MSTRG.7994.1_1 - 0.11 12.3 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain Ank_2 PF12796.5 MSTRG.10594.2_1 - 1.7e-40 137.3 12.8 3.9e-15 56.1 0.1 3.3 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.28 MSTRG.10594.2_1 - 7.7e-21 73.4 0.0 9.7e-05 22.5 0.0 4.7 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.4 MSTRG.10594.2_1 - 8e-21 73.7 3.8 5.2e-11 42.5 0.0 4.4 2 2 2 4 4 4 3 Ankyrin repeats (many copies) KN_motif PF12075.6 MSTRG.10594.2_1 - 2.5e-20 71.8 0.1 5.2e-20 70.8 0.1 1.5 1 0 0 1 1 1 1 KN motif Ank_4 PF13637.4 MSTRG.10594.2_1 - 2.2e-18 66.2 6.3 6.3e-08 32.9 0.0 4.6 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.10594.2_1 - 2.5e-18 64.1 0.1 0.0001 22.3 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat Phage_GP20 PF06810.9 MSTRG.10594.2_1 - 0.021 14.5 5.8 0.13 11.9 0.8 2.7 2 0 0 2 2 2 0 Phage minor structural protein GP20 PBP5_C PF07943.11 MSTRG.10594.2_1 - 0.041 14.0 0.0 0.15 12.1 0.0 2.0 1 0 0 1 1 1 0 Penicillin-binding protein 5, C-terminal domain FlaC_arch PF05377.9 MSTRG.10594.2_1 - 0.4 11.0 3.2 16 5.8 0.1 2.9 3 0 0 3 3 2 0 Flagella accessory protein C (FlaC) DUF2730 PF10805.6 MSTRG.10594.2_1 - 0.93 9.5 5.8 17 5.4 1.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) SlyX PF04102.10 MSTRG.10594.2_1 - 2.9 8.4 8.9 1.9 9.0 2.7 2.9 2 0 0 2 2 2 0 SlyX TolA_bind_tri PF16331.3 MSTRG.10594.2_1 - 6.2 6.8 11.2 0.11 12.4 2.6 2.4 2 1 0 2 2 2 0 TolA binding protein trimerisation ADH_zinc_N_2 PF13602.4 MSTRG.15459.1_3 - 5.5e-20 72.6 0.0 1e-19 71.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.24 MSTRG.15459.1_3 - 1.1e-18 67.3 0.1 1.8e-18 66.6 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 MSTRG.15459.1_3 - 7.3e-11 41.8 0.0 1.7e-10 40.6 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.3 MSTRG.15459.1_3 - 0.092 12.5 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase HLH PF00010.24 MSTRG.15285.3_1 - 2.5e-17 62.4 0.7 4.9e-17 61.5 0.7 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain IncA PF04156.12 MSTRG.15285.3_1 - 0.0022 17.7 2.3 0.0036 17.0 2.3 1.2 1 0 0 1 1 1 1 IncA protein Spc29 PF17082.3 MSTRG.15285.3_1 - 0.0044 16.8 1.3 0.0072 16.1 1.3 1.3 1 0 0 1 1 1 1 Spindle Pole Component 29 Filament PF00038.19 MSTRG.15285.3_1 - 0.027 13.9 6.1 0.034 13.6 6.1 1.1 1 0 0 1 1 1 0 Intermediate filament protein SlyX PF04102.10 MSTRG.15285.3_1 - 0.085 13.4 3.5 0.2 12.2 3.0 1.9 1 1 0 1 1 1 0 SlyX TMF_DNA_bd PF12329.6 MSTRG.15285.3_1 - 0.15 11.9 1.0 0.29 11.0 1.0 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding bZIP_2 PF07716.13 MSTRG.15285.3_1 - 0.95 9.5 7.2 0.091 12.7 2.3 1.9 2 0 0 2 2 2 0 Basic region leucine zipper Sushi PF00084.18 MSTRG.20436.4_2 - 2e-38 130.7 9.8 1.2e-10 41.7 0.4 4.4 4 0 0 4 4 4 4 Sushi repeat (SCR repeat) Glyco_transf_8 PF01501.18 MSTRG.8999.2_1 - 0.00025 20.5 0.0 0.00034 20.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 8 GFO_IDH_MocA PF01408.20 MSTRG.5468.1_1 - 4.1e-20 72.7 0.1 8.1e-20 71.7 0.1 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.15 MSTRG.5468.1_1 - 2.4e-05 24.2 0.0 0.00017 21.5 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain Shikimate_DH PF01488.18 MSTRG.5468.1_1 - 0.0036 17.2 0.0 0.0067 16.4 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.15 MSTRG.5468.1_1 - 0.0095 16.4 0.0 0.025 15.0 0.0 1.7 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Thioredoxin_7 PF13899.4 MSTRG.24992.2_2 - 1.7e-17 63.2 0.0 2.8e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.18 MSTRG.24992.2_2 - 8e-06 25.6 0.0 1.3e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.4 MSTRG.24992.2_2 - 0.0012 19.1 0.0 0.0021 18.4 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredox_DsbH PF03190.13 MSTRG.24992.2_2 - 0.0079 16.0 0.0 0.062 13.1 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function, DUF255 Thioredoxin_9 PF14595.4 MSTRG.24992.2_2 - 0.029 14.0 0.0 0.052 13.2 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin zf-DHHC PF01529.18 MSTRG.24992.2_2 - 1 9.3 3.8 27 4.7 0.0 2.7 2 1 1 3 3 3 0 DHHC palmitoyltransferase dNK PF01712.17 MSTRG.3026.1_1 - 1.4e-64 217.5 0.0 2e-64 217.1 0.0 1.2 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_18 PF13238.4 MSTRG.3026.1_1 - 4.6e-06 27.0 0.0 0.0053 17.1 0.1 2.5 2 1 1 3 3 3 2 AAA domain AAA_33 PF13671.4 MSTRG.3026.1_1 - 8.3e-06 25.9 0.0 0.09 12.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain Thymidylate_kin PF02223.15 MSTRG.3026.1_1 - 0.0056 16.2 0.0 0.019 14.5 0.0 1.8 2 0 0 2 2 2 1 Thymidylate kinase Rdx PF10262.7 MSTRG.25796.1_1 - 3.1e-09 36.8 0.0 5.8e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 Rdx family GOLGA2L5 PF15070.4 MSTRG.13133.3_3 - 1.7e-275 915.5 65.4 1.7e-275 915.5 65.4 2.3 2 0 0 2 2 2 1 Putative golgin subfamily A member 2-like protein 5 Atg14 PF10186.7 MSTRG.13133.3_3 - 0.0004 19.4 3.8 0.0004 19.4 3.8 7.1 2 2 5 7 7 7 2 Vacuolar sorting 38 and autophagy-related subunit 14 Glyco_tranf_2_3 PF13641.4 MSTRG.7521.1_1 - 0.15 11.8 0.4 0.95 9.2 0.0 1.9 2 0 0 2 2 2 0 Glycosyltransferase like family 2 SIX1_SD PF16878.3 MSTRG.7521.1_2 - 1.1e-45 154.5 0.0 1.6e-45 154.0 0.0 1.3 1 0 0 1 1 1 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeobox PF00046.27 MSTRG.7521.1_3 - 1.1e-10 41.0 0.0 2e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 MSTRG.7521.1_3 - 7.6e-10 38.4 0.3 1.5e-09 37.4 0.3 1.4 1 0 0 1 1 1 1 Homeobox KN domain HTH_3 PF01381.20 MSTRG.7521.1_3 - 0.054 13.4 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix Homez PF11569.6 MSTRG.7521.1_3 - 0.11 11.9 0.0 0.25 10.7 0.0 1.6 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Acetyltransf_1 PF00583.23 MSTRG.3885.1_3 - 1.1e-13 51.3 0.0 1.5e-13 50.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.5 MSTRG.3885.1_3 - 6.5e-06 26.3 0.0 1.1e-05 25.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.5 MSTRG.3885.1_3 - 9.2e-06 25.5 0.0 1.4e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.4 MSTRG.3885.1_3 - 0.009 16.0 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.8 MSTRG.3885.1_3 - 0.031 14.1 0.0 0.11 12.4 0.0 1.8 1 1 1 2 2 2 0 FR47-like protein Pkinase_Tyr PF07714.15 MSTRG.27133.1_2 - 1.1e-89 300.1 0.0 1.8e-86 289.5 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.27133.1_2 - 2.2e-36 125.4 0.0 9e-35 120.2 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Kdo PF06293.12 MSTRG.27133.1_2 - 0.055 12.7 0.0 0.09 12.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 MSTRG.27133.1_2 - 0.17 11.1 0.0 0.37 9.9 0.0 1.5 1 1 0 1 1 1 0 Kinase-like UCH PF00443.27 MSTRG.5574.1_1 - 4.8e-59 199.8 1.7 5.9e-59 199.5 1.7 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 MSTRG.5574.1_1 - 1.2e-33 116.9 2.0 1.9e-33 116.3 2.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.4 MSTRG.5574.1_1 - 0.035 13.5 9.3 0.069 12.5 6.9 2.4 2 1 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase SprT-like PF10263.7 MSTRG.5574.1_1 - 6.2 6.5 8.5 0.56 9.9 3.5 1.9 2 1 0 2 2 2 0 SprT-like family CALCOCO1 PF07888.9 MSTRG.14117.3_3 - 8.4e-70 235.9 42.2 2.8e-58 197.8 16.1 2.4 1 1 1 2 2 2 2 Calcium binding and coiled-coil domain (CALCOCO1) like DUF3584 PF12128.6 MSTRG.14117.3_3 - 0.08 10.3 42.7 0.11 9.9 42.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4407 PF14362.4 MSTRG.14117.3_3 - 1.8 7.7 23.7 0.039 13.2 16.3 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) HIP1_clath_bdg PF16515.3 MSTRG.14117.3_3 - 3.3 8.2 47.4 0.043 14.3 18.7 3.3 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 APG6 PF04111.10 MSTRG.14117.3_3 - 5.6 6.1 42.0 9.8 5.3 24.6 2.4 1 1 1 2 2 2 0 Autophagy protein Apg6 CD99L2 PF12301.6 MSTRG.6277.2_1 - 3.5e-14 53.3 20.3 1.2e-13 51.6 20.3 1.7 1 1 0 1 1 1 1 CD99 antigen like protein 2 Brix PF04427.16 MSTRG.15120.1_3 - 3e-41 141.5 0.9 4.7e-41 140.9 0.9 1.3 1 0 0 1 1 1 1 Brix domain POM121 PF15229.4 MSTRG.15120.1_3 - 0.28 10.7 4.0 0.53 9.8 3.4 1.6 2 0 0 2 2 2 0 POM121 family Trypsin PF00089.24 MSTRG.17185.7_1 - 6.2e-81 271.3 3.0 7.2e-81 271.1 3.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 MSTRG.17185.7_1 - 0.0022 18.8 0.1 0.0034 18.1 0.1 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 MSTRG.17185.7_1 - 0.04 14.2 0.1 0.097 12.9 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1986) ArfGap PF01412.16 MSTRG.17104.2_2 - 5.2e-29 100.5 0.0 9.2e-29 99.7 0.0 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Pkinase_Tyr PF07714.15 MSTRG.16025.1_1 - 5.3e-15 55.3 0.0 6.5e-15 55.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Macro PF01661.19 MSTRG.7304.1_3 - 8.5e-18 64.4 0.0 1.2e-17 63.9 0.0 1.2 1 0 0 1 1 1 1 Macro domain Rtf2 PF04641.10 MSTRG.13016.1_1 - 5.3e-94 314.3 9.3 6.5e-94 314.0 9.3 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger zf-NOSIP PF15906.3 MSTRG.13016.1_1 - 0.0091 16.0 0.0 0.022 14.8 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein DUF4699 PF15770.3 MSTRG.13016.1_1 - 0.14 11.7 10.3 0.22 11.1 10.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4699) Prok-RING_1 PF14446.4 MSTRG.13016.1_1 - 0.14 11.9 5.5 3.5 7.5 0.3 2.9 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 DUF4588 PF15251.4 MSTRG.13016.1_1 - 0.26 11.0 8.5 0.36 10.5 8.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4588) DUF4131 PF13567.4 MSTRG.25442.1_2 - 0.74 9.3 3.3 1.5 8.3 3.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Troponin PF00992.18 MSTRG.25442.1_3 - 2.9e-39 134.3 2.9 2.9e-39 134.3 2.9 1.5 2 0 0 2 2 2 1 Troponin TBPIP PF07106.11 MSTRG.25442.1_3 - 0.092 12.4 3.2 0.079 12.6 1.8 1.5 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF2408 PF10303.7 MSTRG.25442.1_3 - 0.37 11.2 3.4 0.68 10.4 3.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) SKG6 PF08693.8 MSTRG.5390.1_2 - 0.16 11.3 1.4 0.24 10.7 0.0 2.0 2 0 0 2 2 2 0 Transmembrane alpha-helix domain SCHIP-1 PF10148.7 MSTRG.8390.1_1 - 2.9e-99 331.3 8.8 3.5e-99 331.0 8.8 1.1 1 0 0 1 1 1 1 Schwannomin-interacting protein 1 FEZ PF07763.11 MSTRG.8390.1_1 - 0.00018 21.2 1.4 0.00033 20.3 1.4 1.4 1 0 0 1 1 1 1 FEZ-like protein BTB PF00651.29 MSTRG.21811.1_1 - 8.7e-11 41.9 0.0 9.8e-09 35.3 0.0 2.3 2 0 0 2 2 2 2 BTB/POZ domain Epimerase_2 PF02350.17 MSTRG.11466.5_3 - 1.1e-66 224.9 0.0 1.7e-66 224.3 0.0 1.2 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase ROK PF00480.18 MSTRG.11466.5_3 - 2.3e-54 184.7 0.9 4e-54 184.0 0.9 1.4 1 0 0 1 1 1 1 ROK family DRTGG PF07085.10 MSTRG.11466.5_3 - 0.0013 18.4 0.1 0.0031 17.2 0.1 1.6 1 0 0 1 1 1 1 DRTGG domain FGGY_N PF00370.19 MSTRG.11466.5_3 - 0.03 13.7 0.0 0.054 12.9 0.0 1.4 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain Hexokinase_1 PF00349.19 MSTRG.11466.5_3 - 0.04 13.8 0.0 0.17 11.7 0.0 1.9 1 1 1 2 2 2 0 Hexokinase FAM212 PF15342.4 MSTRG.1094.1_2 - 0.023 14.4 0.7 0.037 13.7 0.7 1.3 1 0 0 1 1 1 0 FAM212 family GAF_2 PF13185.4 MSTRG.6715.2_1 - 1.6 8.9 4.5 1.8 8.8 0.7 2.1 1 1 1 2 2 2 0 GAF domain Histone PF00125.22 MSTRG.6715.2_2 - 4.6e-40 136.9 0.0 7.9e-40 136.2 0.0 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 ADH_zinc_N_2 PF13602.4 MSTRG.6715.2_2 - 0.092 13.6 0.0 0.15 13.0 0.0 1.3 1 0 0 1 1 1 0 Zinc-binding dehydrogenase E1-E2_ATPase PF00122.18 MSTRG.23306.2_1 - 6.3e-58 195.5 2.4 1.2e-57 194.6 2.4 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 MSTRG.23306.2_1 - 3.4e-42 144.1 0.1 3.4e-42 144.1 0.1 2.7 4 0 0 4 4 4 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 MSTRG.23306.2_1 - 1.9e-24 85.5 0.0 4.2e-24 84.3 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.24 MSTRG.23306.2_1 - 9.9e-20 69.9 0.1 3.9e-19 67.9 0.0 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.24 MSTRG.23306.2_1 - 8.9e-19 68.5 0.1 1.1e-15 58.3 0.1 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.10 MSTRG.23306.2_1 - 2.2e-05 24.2 1.0 0.0015 18.2 0.4 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Phage_holin_3_6 PF07332.9 MSTRG.23306.2_1 - 2.4 8.1 9.6 6.4 6.7 5.3 2.6 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III MOZ_SAS PF01853.16 MSTRG.9380.3_3 - 1.1e-84 282.5 0.7 1.7e-84 281.8 0.7 1.3 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.6 MSTRG.9380.3_3 - 4.2e-19 68.1 0.2 8.5e-19 67.1 0.2 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.5 MSTRG.9380.3_3 - 0.0021 18.3 0.0 0.0045 17.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.23 MSTRG.9380.3_3 - 0.012 15.7 0.0 0.025 14.7 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family WD40 PF00400.30 MSTRG.28587.1_2 - 1.3e-18 66.8 0.0 1.2e-07 32.2 0.0 3.0 2 1 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.28587.1_2 - 0.00061 19.9 0.0 0.0065 16.6 0.1 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 MSTRG.28587.1_2 - 0.0019 16.8 0.1 1.1 7.7 0.0 2.0 1 1 0 2 2 2 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.3 MSTRG.28587.1_2 - 0.12 11.2 0.0 0.16 10.7 0.0 1.3 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein VWA PF00092.26 MSTRG.24405.4_1 - 3.8e-63 212.8 1.3 4.7e-47 160.3 0.1 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.4 MSTRG.24405.4_1 - 2.4e-24 85.9 0.0 1.6e-16 60.8 0.0 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain SRPRB PF09439.8 MSTRG.24405.4_1 - 9.9e-06 25.0 0.0 0.09 12.1 0.0 2.3 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit VWA_3 PF13768.4 MSTRG.24405.4_1 - 2.7e-05 24.0 0.0 0.0097 15.7 0.0 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain DUF2201 PF09967.7 MSTRG.24405.4_1 - 0.062 13.3 1.5 36 4.4 0.0 3.5 4 0 0 4 4 4 0 VWA-like domain (DUF2201) BNIP2 PF12496.6 MSTRG.11049.1_3 - 2.6e-35 121.7 1.5 2.6e-35 121.7 1.5 1.8 2 0 0 2 2 2 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CRAL_TRIO_2 PF13716.4 MSTRG.11049.1_3 - 7.1e-29 100.5 0.6 1.1e-28 100.0 0.6 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.18 MSTRG.11049.1_3 - 2.9e-08 33.5 0.1 4.5e-08 32.8 0.1 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain Ribosomal_L6e PF01159.17 MSTRG.11049.1_3 - 0.095 13.0 0.1 0.27 11.6 0.0 1.7 2 0 0 2 2 2 0 Ribosomal protein L6e DEAD PF00270.27 MSTRG.13823.1_3 - 5e-29 101.2 0.0 8.2e-29 100.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.13823.1_3 - 3.7e-26 91.6 0.3 1.4e-25 89.6 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.13823.1_3 - 5.6e-05 23.1 0.0 0.00011 22.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PP-binding PF00550.23 MSTRG.13823.1_3 - 0.14 12.4 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 Phosphopantetheine attachment site Membr_traf_MHD PF10540.7 MSTRG.5498.1_2 - 7.8e-23 81.3 0.0 1.2e-22 80.7 0.0 1.3 1 0 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.28 MSTRG.5498.1_2 - 2.5e-15 56.5 0.1 6.7e-15 55.1 0.0 1.7 1 1 1 2 2 2 1 C2 domain IQ PF00612.25 MSTRG.18072.1_2 - 1.6e-05 24.2 0.5 3.9e-05 22.9 0.5 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif Transglut_core PF01841.17 MSTRG.13789.1_1 - 1.1e-16 61.1 0.8 2e-16 60.3 0.8 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily Transglut_C PF00927.20 MSTRG.13789.1_1 - 6e-08 32.6 0.0 1e-07 31.9 0.0 1.4 1 0 0 1 1 1 1 Transglutaminase family, C-terminal ig like domain Doppel PF11466.6 MSTRG.4071.1_2 - 0.55 9.8 4.5 1 8.9 4.5 1.4 1 0 0 1 1 1 0 Prion-like protein Doppel EST1_DNA_bind PF10373.7 MSTRG.10418.7_3 - 4.7e-48 164.0 0.5 6.9e-48 163.4 0.5 1.3 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain EST1 PF10374.7 MSTRG.10418.7_3 - 1.8e-07 31.7 1.7 3.3e-07 30.9 0.1 2.4 2 0 0 2 2 2 1 Telomerase activating protein Est1 TPR_7 PF13176.4 MSTRG.10418.7_3 - 0.005 16.6 0.0 0.27 11.2 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.10418.7_3 - 0.051 13.6 0.0 0.15 12.1 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat zf-AD PF07776.13 MSTRG.10418.7_3 - 0.065 13.3 0.2 0.13 12.4 0.2 1.6 1 0 0 1 1 1 0 Zinc-finger associated domain (zf-AD) Mito_carr PF00153.25 MSTRG.2692.4_2 - 2.6e-38 129.7 2.0 4.8e-17 61.5 0.1 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.25 MSTRG.2692.4_3 - 6.8e-21 73.9 0.1 1.4e-20 72.9 0.1 1.5 1 0 0 1 1 1 1 Mitochondrial carrier protein fn3_4 PF16794.3 MSTRG.6377.1_2 - 3.1e-20 71.9 0.0 5.1e-20 71.2 0.0 1.4 1 0 0 1 1 1 1 Fibronectin-III type domain Baculo_PEP_C PF04513.10 MSTRG.6377.1_2 - 0.13 12.2 2.7 0.11 12.4 1.3 1.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Med14 PF08638.9 MSTRG.6377.1_2 - 0.13 11.5 2.7 0.87 8.8 0.0 2.2 2 0 0 2 2 2 0 Mediator complex subunit MED14 Enkurin PF13864.4 MSTRG.6377.1_2 - 0.5 10.7 9.2 2.9 8.3 2.6 2.4 2 0 0 2 2 2 0 Calmodulin-binding DASH_Spc19 PF08287.9 MSTRG.6377.1_2 - 6.2 6.6 12.9 79 3.0 12.5 2.2 1 1 0 1 1 1 0 Spc19 ALMT PF11744.6 MSTRG.6377.1_2 - 7.3 5.2 7.8 9.8 4.7 7.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter HMG_box PF00505.17 MSTRG.17108.1_1 - 0.1 12.9 3.1 0.18 12.1 3.1 1.4 1 0 0 1 1 1 0 HMG (high mobility group) box Josephin PF02099.15 MSTRG.17108.1_2 - 0.028 14.3 0.1 0.043 13.7 0.1 1.3 1 0 0 1 1 1 0 Josephin DUF913 PF06025.10 MSTRG.11777.1_2 - 2.4e-112 375.4 0.1 2.4e-112 375.4 0.1 5.2 5 1 0 5 5 5 1 Domain of Unknown Function (DUF913) HECT PF00632.23 MSTRG.11777.1_2 - 6.1e-93 311.5 0.4 1e-92 310.8 0.4 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF4414 PF14377.4 MSTRG.11777.1_2 - 2.4e-27 95.4 3.0 2.4e-27 95.4 3.0 6.4 5 1 1 6 6 6 1 Domain of unknown function (DUF4414) DUF908 PF06012.10 MSTRG.11777.1_2 - 3.7e-26 92.3 6.6 3.7e-26 92.3 6.6 5.4 6 1 0 6 6 6 1 Domain of Unknown Function (DUF908) WWE PF02825.18 MSTRG.11777.1_2 - 2.6e-13 50.2 2.0 7.7e-13 48.7 2.0 1.8 1 0 0 1 1 1 1 WWE domain UBA PF00627.29 MSTRG.11777.1_2 - 3.7e-06 26.6 0.5 9.6e-06 25.3 0.5 1.8 1 0 0 1 1 1 1 UBA/TS-N domain BAR PF03114.16 MSTRG.14236.2_3 - 7.2e-55 186.1 10.3 7.5e-55 186.0 9.0 1.6 2 0 0 2 2 2 1 BAR domain RhoGAP PF00620.25 MSTRG.14236.2_3 - 7.8e-41 139.3 0.0 1.7e-40 138.2 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain BAR_3 PF16746.3 MSTRG.14236.2_3 - 0.0025 17.4 0.4 0.0051 16.4 0.2 1.6 1 1 0 1 1 1 1 BAR domain of APPL family BAR_2 PF10455.7 MSTRG.14236.2_3 - 0.045 12.8 4.4 0.078 12.0 4.4 1.4 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking WD40 PF00400.30 MSTRG.8302.1_1 - 6.9e-26 89.9 6.8 2.3e-05 24.9 0.2 6.3 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.8302.1_1 - 3.2e-06 27.2 0.1 0.29 11.3 0.1 4.6 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 MSTRG.8302.1_1 - 0.0018 18.0 0.0 0.0086 15.8 0.0 1.9 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.3 MSTRG.8302.1_1 - 0.026 13.4 0.0 0.076 11.8 0.0 1.7 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein p450 PF00067.20 MSTRG.12933.7_1 - 2.9e-129 431.7 0.3 3.5e-129 431.4 0.3 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.20 MSTRG.12933.7_2 - 6.8e-133 443.7 0.2 8.4e-133 443.3 0.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 zf-DHHC PF01529.18 MSTRG.17220.1_3 - 4.9e-28 97.8 8.0 4.9e-28 97.8 8.0 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase SOUL PF04832.10 MSTRG.18350.1_1 - 9e-33 113.7 0.0 1.3e-32 113.2 0.0 1.2 1 0 0 1 1 1 1 SOUL heme-binding protein DUF591 PF04569.12 MSTRG.18350.1_3 - 2 8.7 14.0 5.7 7.2 14.0 1.7 1 0 0 1 1 1 0 Protein of unknown function Laminin_I PF06008.12 MSTRG.11963.3_2 - 1.7e-49 168.7 47.4 9.4e-49 166.3 16.3 4.2 2 1 2 4 4 4 2 Laminin Domain I Laminin_II PF06009.10 MSTRG.11963.3_2 - 7.7e-24 84.1 51.5 1e-23 83.8 11.1 5.8 4 1 0 5 5 5 3 Laminin Domain II Laminin_EGF PF00053.22 MSTRG.11963.3_2 - 2e-11 43.7 31.2 4.3e-06 26.6 16.4 2.3 2 0 0 2 2 2 2 Laminin EGF domain DUF948 PF06103.9 MSTRG.11963.3_2 - 2.3e-05 24.4 34.2 0.025 14.7 0.6 7.7 3 2 4 7 7 7 3 Bacterial protein of unknown function (DUF948) SLT PF01464.18 MSTRG.11963.3_2 - 0.048 13.2 1.4 1.9 8.0 0.0 2.5 2 0 0 2 2 2 0 Transglycosylase SLT domain Nsp1_C PF05064.11 MSTRG.11963.3_2 - 0.051 13.3 12.9 0.034 13.8 1.7 4.3 3 1 1 4 4 4 0 Nsp1-like C-terminal region DUF4795 PF16043.3 MSTRG.11963.3_2 - 0.17 11.3 46.6 0.51 9.8 11.0 3.8 3 1 0 3 3 3 0 Domain of unknown function (DUF4795) Corona_S2 PF01601.14 MSTRG.11963.3_2 - 0.19 10.1 1.5 0.34 9.2 1.5 1.4 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Fib_alpha PF08702.8 MSTRG.11963.3_2 - 0.22 11.6 27.8 0.23 11.5 0.5 5.3 3 2 3 6 6 6 0 Fibrinogen alpha/beta chain family MHCassoc_trimer PF08831.8 MSTRG.11963.3_2 - 2.1 8.3 7.8 13 5.7 0.1 3.6 3 0 0 3 3 3 0 Class II MHC-associated invariant chain trimerisation domain BLOC1_2 PF10046.7 MSTRG.11963.3_2 - 2.7 8.2 34.6 0.13 12.5 0.5 7.0 4 3 3 7 7 7 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PspA_IM30 PF04012.10 MSTRG.11963.3_2 - 3.3 7.1 64.6 1 8.7 2.1 5.7 3 2 2 5 5 5 0 PspA/IM30 family Reo_sigmaC PF04582.10 MSTRG.11963.3_2 - 3.6 6.8 16.5 0.69 9.1 2.9 3.5 2 1 2 4 4 4 0 Reovirus sigma C capsid protein DASH_Dam1 PF08653.8 MSTRG.11963.3_2 - 8.4 6.1 7.8 28 4.5 0.1 4.7 4 1 0 4 4 4 0 DASH complex subunit Dam1 Notch PF00066.15 MSTRG.7071.2_2 - 0.022 15.1 11.3 0.022 15.1 11.3 3.2 3 0 0 3 3 3 0 LNR domain Fusion_gly PF00523.16 MSTRG.11632.4_1 - 0.053 11.6 2.4 0.067 11.3 2.4 1.1 1 0 0 1 1 1 0 Fusion glycoprotein F0 FA_hydroxylase PF04116.11 MSTRG.11632.4_3 - 8.7e-09 35.7 1.5 1.3e-08 35.2 1.5 1.2 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily Anth_synt_I_N PF04715.11 MSTRG.11632.4_3 - 0.022 14.8 0.7 0.032 14.3 0.7 1.2 1 0 0 1 1 1 0 Anthranilate synthase component I, N terminal region COX14 PF14880.4 MSTRG.11632.4_3 - 0.84 9.4 9.6 0.084 12.6 4.2 2.1 2 0 0 2 2 2 0 Cytochrome oxidase c assembly RRM_1 PF00076.20 MSTRG.2147.1_2 - 0.092 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.20 MSTRG.2147.1_3 - 6.3e-12 45.0 0.0 0.03 14.0 0.0 4.2 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GILT PF03227.14 MSTRG.18820.3_2 - 5.6e-27 93.9 1.7 9.5e-27 93.2 1.7 1.4 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) SDF PF00375.16 MSTRG.22083.1_3 - 8.5e-133 443.0 30.2 1.1e-132 442.6 30.2 1.2 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family Lipocalin PF00061.21 MSTRG.9962.3_2 - 1.2e-25 90.3 2.5 1.7e-25 89.8 2.5 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 MSTRG.9962.3_2 - 3.7e-09 36.5 1.2 5.6e-09 35.9 1.2 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Actin PF00022.17 MSTRG.20389.3_2 - 1e-89 300.9 0.0 2.7e-56 190.8 0.0 2.1 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.11 MSTRG.20389.3_2 - 0.00027 19.7 0.0 0.22 10.1 0.0 2.4 2 0 0 2 2 2 2 MreB/Mbl protein Robl_LC7 PF03259.15 MSTRG.20389.3_2 - 0.14 11.8 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 Roadblock/LC7 domain Mito_carr PF00153.25 MSTRG.10263.2_2 - 2.3e-32 110.6 0.1 6.8e-11 41.8 0.0 3.6 3 0 0 3 3 3 3 Mitochondrial carrier protein WBP-1 PF11669.6 MSTRG.11991.1_3 - 6.6e-41 139.0 10.2 1.9e-40 137.6 10.2 1.8 1 0 0 1 1 1 1 WW domain-binding protein 1 Glyco_transf_7N PF13733.4 MSTRG.25780.3_2 - 5.7e-59 197.4 0.0 8.4e-59 196.9 0.0 1.2 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.12 MSTRG.25780.3_2 - 1.5e-32 110.9 0.5 2.8e-32 110.1 0.5 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 MSTRG.25780.3_2 - 0.016 14.5 0.0 0.039 13.3 0.0 1.5 1 1 1 2 2 2 0 Glycosyltransferase like family 2 Spectrin PF00435.19 MSTRG.8897.3_1 - 1.9e-68 227.5 22.8 9e-24 83.9 6.2 4.2 4 0 0 4 4 4 4 Spectrin repeat EFhand_Ca_insen PF08726.8 MSTRG.8897.3_1 - 1.9e-26 91.8 0.0 6.3e-26 90.1 0.0 2.0 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_1 PF00036.30 MSTRG.8897.3_1 - 1.1e-06 27.7 0.7 0.0056 16.0 0.1 2.9 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.4 MSTRG.8897.3_1 - 8.8e-06 25.3 0.4 3.5e-05 23.3 0.2 2.3 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.4 MSTRG.8897.3_1 - 2.6e-05 24.5 0.1 9.6e-05 22.6 0.1 2.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.8897.3_1 - 4.9e-05 22.8 0.3 0.0048 16.6 0.1 3.1 2 0 0 2 2 2 1 EF-hand domain XisI PF08869.9 MSTRG.8897.3_1 - 0.002 18.3 0.4 0.0076 16.5 0.4 2.0 1 0 0 1 1 1 1 XisI protein EF-hand_11 PF08976.9 MSTRG.8897.3_1 - 0.12 13.1 0.2 0.5 11.1 0.1 2.1 2 0 0 2 2 2 0 EF-hand domain Uds1 PF15456.4 MSTRG.8897.3_1 - 1.1 9.3 8.0 0.66 10.0 3.1 2.8 2 1 0 2 2 2 0 Up-regulated During Septation Ras PF00071.20 MSTRG.22991.1_2 - 5.4e-55 185.3 0.0 6.7e-55 185.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.22991.1_2 - 1.6e-28 99.2 0.0 2.4e-28 98.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.22991.1_2 - 4.1e-11 42.5 0.0 6e-11 42.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 MSTRG.22991.1_2 - 0.00012 22.0 0.0 0.00018 21.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 MSTRG.22991.1_2 - 0.001 18.3 0.0 0.0013 18.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF258 PF03193.14 MSTRG.22991.1_2 - 0.0051 16.6 0.0 0.06 13.1 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF258 G-alpha PF00503.18 MSTRG.22991.1_2 - 0.019 14.0 0.4 3.7 6.5 0.1 2.6 1 1 1 2 2 2 0 G-protein alpha subunit GTP_EFTU PF00009.25 MSTRG.22991.1_2 - 0.056 12.8 0.0 0.085 12.2 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain ATP-synt_D PF01813.15 MSTRG.25609.1_2 - 6.5e-76 254.4 7.6 8.3e-76 254.1 7.6 1.1 1 0 0 1 1 1 1 ATP synthase subunit D Resolvase PF00239.19 MSTRG.25609.1_2 - 0.058 13.3 5.0 0.048 13.6 1.8 2.4 2 1 0 2 2 2 0 Resolvase, N terminal domain Tetraspannin PF00335.18 MSTRG.1564.1_3 - 4.8e-19 68.9 15.8 7.5e-19 68.2 15.8 1.3 1 0 0 1 1 1 1 Tetraspanin family Trypan_PARP PF05887.9 MSTRG.1564.1_3 - 4.8 7.1 11.8 19 5.1 12.3 1.7 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) RecA_dep_nuc PF16786.3 MSTRG.20201.1_1 - 0.89 9.6 4.1 4 7.5 1.2 2.3 2 0 0 2 2 2 0 Recombination enhancement, RecA-dependent nuclease PWWP PF00855.15 MSTRG.20201.1_3 - 6.6e-13 48.8 0.4 1.2e-12 47.9 0.4 1.4 1 0 0 1 1 1 1 PWWP domain FA_desaturase PF00487.22 MSTRG.25015.1_3 - 1.1e-35 123.5 26.1 1.1e-35 123.5 26.1 2.0 2 0 0 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.26 MSTRG.25015.1_3 - 7.3e-22 77.2 0.0 1.4e-21 76.3 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain GH-E PF14410.4 MSTRG.25015.1_3 - 4.2 7.7 5.3 0.57 10.5 0.6 2.0 2 0 0 2 2 2 0 HNH/ENDO VII superfamily nuclease with conserved GHE residues THAP PF05485.10 MSTRG.17036.1_3 - 2.4e-16 60.3 2.7 3.5e-16 59.8 1.8 1.8 2 0 0 2 2 2 1 THAP domain Tnp_P_element PF12017.6 MSTRG.17036.1_3 - 0.00022 20.6 0.0 0.00042 19.7 0.0 1.4 1 0 0 1 1 1 1 Transposase protein Guanylate_cyc PF00211.18 MSTRG.5441.1_2 - 1.9e-121 402.3 0.2 1.4e-62 210.5 0.0 2.3 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain DUF1053 PF06327.12 MSTRG.5441.1_2 - 1.5e-20 73.5 0.2 2.9e-20 72.6 0.2 1.5 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1053) AC_N PF16214.3 MSTRG.5441.1_2 - 6.2e-20 71.6 8.8 6.2e-20 71.6 8.8 2.0 2 0 0 2 2 2 1 Adenylyl cyclase N-terminal extracellular and transmembrane region MgtE PF01769.14 MSTRG.5441.1_2 - 2.4 8.4 0.0 2.4 8.4 0.0 4.7 4 2 1 5 5 5 0 Divalent cation transporter WD40 PF00400.30 MSTRG.20401.1_2 - 5.1e-33 112.4 29.8 4.5e-09 36.7 0.1 11.5 12 0 0 12 12 12 5 WD domain, G-beta repeat Utp12 PF04003.10 MSTRG.20401.1_2 - 9e-24 83.7 0.2 1.4e-23 83.1 0.2 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.5 MSTRG.20401.1_2 - 5.3e-21 74.6 0.0 0.0026 17.9 0.0 8.8 2 2 5 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 MSTRG.20401.1_2 - 1.3e-07 30.8 0.3 0.39 9.5 0.2 4.4 2 2 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.3 MSTRG.20401.1_2 - 2.4e-06 26.9 2.8 0.00059 19.1 0.0 3.8 4 1 0 4 4 4 1 WD40-like domain eIF2A PF08662.9 MSTRG.20401.1_2 - 2.5e-06 27.4 1.0 0.43 10.3 0.2 4.8 3 2 1 5 5 5 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.10 MSTRG.20401.1_2 - 0.0029 17.4 0.0 4.7 7.1 0.0 4.0 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Utp21 PF04192.10 MSTRG.20401.1_2 - 0.01 15.2 0.2 0.01 15.2 0.2 2.9 3 0 0 3 3 3 0 Utp21 specific WD40 associated putative domain DUF2722 PF10846.6 MSTRG.20401.1_2 - 0.018 13.9 0.4 0.018 13.9 0.4 1.5 2 0 0 2 2 1 0 Protein of unknown function (DUF2722) DUF1513 PF07433.9 MSTRG.20401.1_2 - 0.024 13.6 0.1 2 7.3 0.0 3.0 2 1 0 3 3 3 0 Protein of unknown function (DUF1513) TFIIIC_delta PF12657.5 MSTRG.20401.1_2 - 0.028 14.2 0.1 6.6 6.5 0.0 3.9 5 0 0 5 5 4 0 Transcription factor IIIC subunit delta N-term UTP15_C PF09384.8 MSTRG.20401.1_2 - 0.058 13.0 0.2 0.2 11.3 0.2 1.9 1 1 0 1 1 1 0 UTP15 C terminal CDC45 PF02724.12 MSTRG.20401.1_2 - 2.5 6.2 15.7 0.59 8.2 0.1 2.1 2 0 0 2 2 2 0 CDC45-like protein DARPP-32 PF05395.10 MSTRG.20401.1_2 - 3 7.9 13.2 0.068 13.3 2.7 2.2 2 0 0 2 2 2 0 Protein phosphatase inhibitor 1/DARPP-32 RINGv PF12906.5 MSTRG.14688.1_2 - 3.7e-14 52.5 10.6 7.4e-14 51.5 10.6 1.5 1 0 0 1 1 1 1 RING-variant domain DUF2517 PF10725.7 MSTRG.14688.1_2 - 0.0052 16.4 0.1 0.014 15.0 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2517) FANCL_C PF11793.6 MSTRG.14688.1_2 - 0.035 14.1 4.6 0.14 12.3 5.0 1.7 2 0 0 2 2 2 0 FANCL C-terminal domain zf-RING_4 PF14570.4 MSTRG.14688.1_2 - 1.2 8.8 5.9 2.6 7.7 5.9 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain PHD PF00628.27 MSTRG.14688.1_2 - 3.2 7.6 8.4 7 6.5 8.4 1.6 1 0 0 1 1 1 0 PHD-finger Sugar_tr PF00083.22 MSTRG.24939.1_1 - 1.4e-24 86.6 14.2 1.4e-24 86.6 14.2 1.5 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.14 MSTRG.24939.1_1 - 3.9e-19 68.6 36.0 5.3e-15 55.1 15.9 2.4 2 1 1 3 3 3 2 Major Facilitator Superfamily SSF PF00474.15 MSTRG.4667.2_2 - 1.4e-24 86.6 13.0 2.1e-24 86.0 13.0 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family DUF938 PF06080.10 MSTRG.4667.2_2 - 0.053 13.2 0.1 7.3 6.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF938) SSF PF00474.15 MSTRG.4667.2_3 - 1.3e-30 106.5 17.5 2e-30 105.9 17.5 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family RCC1 PF00415.16 MSTRG.17214.2_3 - 1.6e-80 265.4 14.0 1.2e-11 44.9 0.0 7.1 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 MSTRG.17214.2_3 - 1.8e-27 94.4 28.2 2.6e-09 36.5 0.4 8.0 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat Peptidase_C25_C PF03785.12 MSTRG.17214.2_3 - 6.4e-06 25.8 0.1 0.022 14.4 0.1 3.5 3 0 0 3 3 3 1 Peptidase family C25, C terminal ig-like domain Hira PF07569.9 MSTRG.17214.2_3 - 0.09 12.4 0.1 5.2 6.6 0.0 2.9 2 1 0 3 3 3 0 TUP1-like enhancer of split PapC_C PF13953.4 MSTRG.17214.2_3 - 0.1 12.4 1.1 0.61 9.9 0.2 2.7 2 0 0 2 2 2 0 PapC C-terminal domain SUKH-3 PF14433.4 MSTRG.17214.2_3 - 0.24 11.8 0.6 22 5.4 0.0 3.6 4 0 0 4 4 4 0 SUKH-3 immunity protein DOCK_N PF16172.3 MSTRG.4877.4_3 - 5.2e-112 374.3 0.4 9.7e-112 373.5 0.4 1.5 1 0 0 1 1 1 1 DOCK N-terminus DHR-2 PF06920.11 MSTRG.4877.4_3 - 3.4e-97 326.2 9.0 6.8e-83 279.0 1.7 2.5 2 0 0 2 2 2 2 Dock homology region 2 DOCK-C2 PF14429.4 MSTRG.4877.4_3 - 1.6e-60 204.1 0.2 4e-60 202.8 0.2 1.7 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins LRR_8 PF13855.4 MSTRG.12778.2_1 - 2.5e-34 116.7 52.8 3.1e-08 33.1 0.1 8.7 5 2 2 9 9 9 7 Leucine rich repeat PP2C PF00481.19 MSTRG.12778.2_1 - 6.4e-34 117.6 0.0 1.1e-33 116.9 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_4 PF12799.5 MSTRG.12778.2_1 - 1.9e-21 75.5 60.9 0.00049 20.3 0.5 11.7 11 1 1 12 12 12 8 Leucine Rich repeats (2 copies) PH PF00169.27 MSTRG.12778.2_1 - 7.7e-05 23.0 0.0 0.00021 21.6 0.0 1.7 1 0 0 1 1 1 1 PH domain LRR_9 PF14580.4 MSTRG.12778.2_1 - 0.07 12.5 15.9 0.59 9.5 0.0 4.8 1 1 4 5 5 5 0 Leucine-rich repeat LRR_1 PF00560.31 MSTRG.12778.2_1 - 0.15 12.5 50.0 5.8 7.7 0.5 14.8 15 2 0 15 15 15 0 Leucine Rich Repeat LRR_6 PF13516.4 MSTRG.12778.2_1 - 2.6 8.2 45.6 26 5.1 0.5 13.3 14 0 0 14 14 14 0 Leucine Rich repeat DUF3402 PF11882.6 MSTRG.1627.1_1 - 3.2e-102 342.9 21.0 8.2e-66 222.9 5.4 3.3 1 1 1 2 2 2 2 Domain of unknown function (DUF3402) N1221 PF07923.11 MSTRG.1627.1_1 - 1.2e-51 175.6 0.0 1.9e-51 174.9 0.0 1.3 1 0 0 1 1 1 1 N1221-like protein FAM165 PF14981.4 MSTRG.20167.1_2 - 1.4e-27 95.0 3.6 2.9e-27 94.1 3.6 1.5 1 0 0 1 1 1 1 FAM165 family Crystall PF00030.17 MSTRG.16990.1_3 - 3.2e-56 187.3 10.1 5.5e-28 96.9 2.1 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 MSTRG.16990.1_3 - 3.4e-05 23.5 1.6 0.11 12.4 0.1 2.5 2 0 0 2 2 2 2 Peptidase inhibitor family I36 DUF2914 PF11141.6 MSTRG.16990.1_3 - 0.0074 15.9 0.1 0.041 13.5 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2914) YiaAB PF05360.12 MSTRG.17530.1_3 - 0.012 15.7 0.1 8.4 6.6 0.0 3.9 5 0 0 5 5 5 0 yiaA/B two helix domain Nsp1_C PF05064.11 MSTRG.25401.1_2 - 1.3e-38 131.2 5.2 2.9e-38 130.1 5.2 1.5 1 0 0 1 1 1 1 Nsp1-like C-terminal region Exonuc_VII_L PF02601.13 MSTRG.25401.1_2 - 0.29 10.5 7.9 0.52 9.7 7.9 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4164 PF13747.4 MSTRG.25401.1_2 - 1.4 9.1 5.5 0.52 10.5 1.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) Laminin_II PF06009.10 MSTRG.25401.1_2 - 2.5 8.0 8.9 6.4 6.7 2.2 2.3 2 0 0 2 2 2 0 Laminin Domain II Ig_3 PF13927.4 MSTRG.27002.1_2 - 9e-26 90.2 0.0 3.2e-07 30.7 0.0 5.5 4 3 0 4 4 4 4 Immunoglobulin domain V-set PF07686.15 MSTRG.27002.1_2 - 1.2e-23 83.2 0.1 1.4e-06 28.3 0.0 5.8 4 2 0 4 4 4 4 Immunoglobulin V-set domain I-set PF07679.14 MSTRG.27002.1_2 - 1.4e-17 63.4 0.3 1.4e-05 25.0 0.0 5.7 4 2 0 4 4 4 3 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.27002.1_2 - 3e-12 46.6 4.5 0.65 10.2 0.1 7.3 5 3 0 5 5 5 4 Immunoglobulin domain ig PF00047.23 MSTRG.27002.1_2 - 5e-12 45.7 0.1 0.023 14.7 0.0 6.3 5 3 0 5 5 5 4 Immunoglobulin domain Izumo-Ig PF16706.3 MSTRG.27002.1_2 - 0.0028 17.5 0.1 8.5 6.4 0.0 4.0 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain MIP-T3 PF10243.7 MSTRG.13811.1_2 - 0.31 9.6 3.7 0.36 9.4 3.7 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 MFAP1 PF06991.9 MSTRG.5913.1_2 - 8.9e-75 251.1 30.7 8.9e-75 251.1 30.7 2.6 1 1 1 2 2 2 1 Microfibril-associated/Pre-mRNA processing UEV PF05743.11 MSTRG.22102.1_2 - 5.8e-36 122.9 0.2 8.2e-36 122.4 0.2 1.2 1 0 0 1 1 1 1 UEV domain RWD PF05773.20 MSTRG.22102.1_2 - 0.066 13.4 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 RWD domain Histone PF00125.22 MSTRG.4969.1_3 - 6e-18 65.4 0.1 8.8e-18 64.8 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.3 MSTRG.4969.1_3 - 2.5e-12 46.2 0.5 4.7e-12 45.3 0.5 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.21 MSTRG.4969.1_3 - 0.078 13.1 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Phosphodiest PF01663.20 MSTRG.25593.1_2 - 6.2e-82 275.9 0.0 8.2e-82 275.5 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Endonuclease_NS PF01223.21 MSTRG.25593.1_2 - 0.0014 18.4 0.0 0.0053 16.5 0.0 1.8 1 1 0 1 1 1 1 DNA/RNA non-specific endonuclease Sulfatase PF00884.21 MSTRG.25593.1_2 - 0.0048 16.2 0.0 0.24 10.6 0.0 2.2 1 1 0 1 1 1 1 Sulfatase Abi_HHR PF07815.12 MSTRG.19223.3_3 - 1.3e-34 118.0 0.5 2.8e-34 117.0 0.5 1.5 1 0 0 1 1 1 1 Abl-interactor HHR SH3_9 PF14604.4 MSTRG.19223.3_3 - 1.7e-15 56.5 0.2 3.6e-15 55.4 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.19223.3_3 - 5.8e-15 54.5 0.1 1e-14 53.7 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.19223.3_3 - 3.4e-10 39.3 0.1 6.9e-10 38.4 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain Macro PF01661.19 MSTRG.7770.1_2 - 9.2e-39 132.0 0.1 1.5e-38 131.3 0.1 1.4 1 0 0 1 1 1 1 Macro domain 6PF2K PF01591.16 MSTRG.14031.3_2 - 5e-100 333.3 0.4 1e-99 332.3 0.2 1.6 2 0 0 2 2 2 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.20 MSTRG.14031.3_2 - 1.7e-37 128.9 0.0 2.4e-37 128.4 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.4 MSTRG.14031.3_2 - 3.2e-07 30.5 0.0 5.9e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.8 MSTRG.14031.3_2 - 0.064 12.5 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 DUF3652 PF12372.6 MSTRG.18986.2_3 - 4.4e-21 74.4 1.1 3e-20 71.7 0.9 2.6 2 0 0 2 2 2 1 Huntingtin protein region HEAT PF02985.20 MSTRG.18986.2_3 - 3.3e-08 32.9 14.1 0.0073 16.3 0.1 7.8 7 0 0 7 7 7 3 HEAT repeat HEAT_2 PF13646.4 MSTRG.18986.2_3 - 1.3e-05 25.4 4.7 0.077 13.3 0.2 4.9 4 1 1 5 5 5 3 HEAT repeats Vac14_Fab1_bd PF12755.5 MSTRG.18986.2_3 - 0.0015 18.9 0.6 1.1 9.8 0.0 3.7 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.4 MSTRG.18986.2_3 - 0.0078 16.5 5.6 11 6.5 0.0 5.5 4 0 0 4 4 4 2 HEAT-like repeat Arm PF00514.21 MSTRG.18986.2_3 - 0.034 14.1 0.9 0.76 9.8 0.0 3.8 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Cnd1 PF12717.5 MSTRG.18986.2_3 - 0.049 13.5 6.1 1.9 8.4 0.1 5.2 4 1 1 5 5 5 0 non-SMC mitotic condensation complex subunit 1 Nop16 PF09420.8 MSTRG.56.1_3 - 1.6e-18 67.4 14.7 3.2e-12 46.8 1.6 2.2 1 1 1 2 2 2 2 Ribosome biogenesis protein Nop16 SEFIR PF08357.9 MSTRG.9346.1_2 - 2.8e-21 76.2 0.0 5.4e-21 75.3 0.0 1.5 1 0 0 1 1 1 1 SEFIR domain Actin PF00022.17 MSTRG.9346.1_3 - 5.3e-34 117.4 0.0 4.8e-17 61.5 0.0 3.1 2 1 0 2 2 2 2 Actin Actin_micro PF17003.3 MSTRG.9346.1_3 - 3.1e-10 39.7 0.2 0.00023 20.3 0.1 2.1 2 0 0 2 2 2 2 Putative actin-like family Kinesin PF00225.21 MSTRG.7356.1_1 - 9.6e-120 399.3 0.1 1.7e-119 398.6 0.1 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 MSTRG.7356.1_1 - 3.2e-27 95.2 0.1 1e-26 93.5 0.0 1.9 2 0 0 2 2 2 1 Microtubule binding CheZ PF04344.11 MSTRG.7356.1_1 - 0.003 17.4 3.6 0.003 17.4 3.6 2.1 2 0 0 2 2 2 1 Chemotaxis phosphatase, CheZ AAA_22 PF13401.4 MSTRG.7356.1_1 - 0.7 10.0 8.9 3.5 7.8 0.0 3.3 2 1 1 3 3 3 0 AAA domain VWA_N2 PF16164.3 MSTRG.2404.1_2 - 0.031 14.3 2.8 0.057 13.5 2.8 1.3 1 0 0 1 1 1 0 VWA N-terminal Glucosamine_iso PF01182.18 MSTRG.27041.2_1 - 8.8e-62 208.8 0.0 1.4e-61 208.1 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase G6PD_C PF02781.14 MSTRG.27041.2_1 - 3.9e-56 190.3 0.0 5.3e-56 189.8 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.20 MSTRG.27041.2_1 - 3.5e-32 112.3 0.0 6e-32 111.6 0.0 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain PDZ PF00595.22 MSTRG.16635.1_1 - 2e-15 56.8 0.2 3.4e-15 56.0 0.2 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) DUF4749 PF15936.3 MSTRG.16635.1_1 - 2.5e-11 44.5 0.7 6.4e-11 43.2 0.7 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) LIM PF00412.20 MSTRG.16635.1_1 - 3.3e-08 33.5 4.0 6.5e-08 32.6 4.0 1.5 1 0 0 1 1 1 1 LIM domain PDZ_2 PF13180.4 MSTRG.16635.1_1 - 2.6e-05 24.3 0.0 5.2e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 PDZ domain RbpA PF13397.4 MSTRG.16635.1_1 - 0.17 12.3 0.3 0.84 10.1 0.0 2.2 3 0 0 3 3 3 0 RNA polymerase-binding protein SSF PF00474.15 MSTRG.24330.2_1 - 1e-46 159.5 15.4 1.8e-46 158.7 15.4 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family Umbravirus_LDM PF04817.10 MSTRG.24330.2_2 - 0.089 12.0 3.0 0.15 11.3 3.0 1.2 1 0 0 1 1 1 0 Umbravirus long distance movement (LDM) family Goodbye PF17109.3 MSTRG.27755.1_3 - 0.09 13.1 0.0 0.1 12.9 0.0 1.1 1 0 0 1 1 1 0 fungal STAND N-terminal Goodbye domain TMCO5 PF14992.4 MSTRG.27755.1_3 - 0.18 11.3 0.1 0.21 11.0 0.1 1.0 1 0 0 1 1 1 0 TMCO5 family MBOAT PF03062.17 MSTRG.19560.1_2 - 4.5e-08 32.7 4.5 9.3e-08 31.7 4.5 1.6 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Pkinase_Tyr PF07714.15 MSTRG.26373.1_3 - 5.9e-36 124.0 0.0 8.4e-36 123.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.26373.1_3 - 1.7e-35 122.5 0.0 2.9e-35 121.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain TGF_beta_GS PF08515.10 MSTRG.26373.1_3 - 5.5e-15 54.4 0.5 1.2e-14 53.4 0.5 1.6 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Activin_recp PF01064.21 MSTRG.26373.1_3 - 3.2e-14 53.6 15.7 3.2e-14 53.6 15.7 2.0 2 0 0 2 2 2 1 Activin types I and II receptor domain FTA2 PF13095.4 MSTRG.26373.1_3 - 0.083 12.4 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 BAMBI PF06211.10 MSTRG.26373.1_3 - 3.3 7.9 11.0 1.3 9.2 7.9 1.9 2 0 0 2 2 2 0 BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain ETAA1 PF15350.4 MSTRG.18317.1_1 - 9.2e-28 96.9 29.6 3e-13 48.9 1.0 5.2 2 1 2 5 5 5 5 Ewing's tumour-associated antigen 1 homologue Seryl_tRNA_N PF02403.20 MSTRG.18317.1_1 - 0.0087 16.1 2.4 0.032 14.3 2.4 2.0 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain 2-Hacid_dh_C PF02826.17 MSTRG.10270.2_3 - 3.1e-58 195.9 0.0 4.1e-58 195.5 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.28 MSTRG.10270.2_3 - 1.1e-28 99.5 0.0 1.3e-28 99.2 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.13 MSTRG.10270.2_3 - 0.00014 21.9 0.0 0.00026 21.1 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.18 MSTRG.10270.2_3 - 0.0039 17.1 0.0 0.0074 16.2 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.15 MSTRG.10270.2_3 - 0.012 16.0 0.0 0.029 14.8 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent KR PF08659.8 MSTRG.10270.2_3 - 0.032 14.0 0.0 0.064 13.0 0.0 1.6 1 0 0 1 1 1 0 KR domain ThiF PF00899.19 MSTRG.10270.2_3 - 0.2 10.9 3.0 0.36 10.0 1.1 2.0 2 0 0 2 2 2 0 ThiF family DUF3432 PF11914.6 MSTRG.10337.1_2 - 6.8e-27 93.5 41.7 6.8e-27 93.5 41.7 3.6 2 1 1 3 3 1 1 Domain of unknown function (DUF3432) DUF3446 PF11928.6 MSTRG.10337.1_2 - 5.1e-16 58.6 38.7 2.2e-10 40.5 11.0 5.8 3 2 1 4 4 3 2 Domain of unknown function (DUF3446) zf-H2C2_2 PF13465.4 MSTRG.10337.1_2 - 2.1e-14 53.1 19.9 2.5e-07 30.7 0.7 4.8 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.10337.1_2 - 2.4e-13 49.6 20.6 3e-05 24.1 0.3 4.7 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.10337.1_2 - 8.5e-08 32.3 22.4 0.007 17.0 2.1 5.2 4 0 0 4 4 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.10337.1_2 - 0.0039 17.3 1.5 27 5.1 0.0 3.8 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 MSTRG.10337.1_2 - 0.0088 15.8 3.6 7 6.6 0.3 4.0 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2HC_2 PF13913.4 MSTRG.10337.1_2 - 0.023 14.5 8.2 0.62 9.9 0.4 3.6 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-BED PF02892.13 MSTRG.10337.1_2 - 0.034 14.1 7.4 0.028 14.3 2.8 2.7 1 1 1 2 2 2 0 BED zinc finger Zf_RING PF16744.3 MSTRG.10337.1_2 - 0.05 13.6 1.6 0.79 9.7 0.1 2.4 1 1 1 2 2 2 0 KIAA1045 RING finger zf-met PF12874.5 MSTRG.10337.1_2 - 0.054 13.8 8.3 7.3 7.0 1.3 3.9 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 MSTRG.10337.1_2 - 4.5 7.0 6.6 75 3.1 0.4 3.8 3 0 0 3 3 3 0 zinc-finger C2H2-type ABC_membrane PF00664.21 MSTRG.26811.3_3 - 4.1e-35 121.6 1.8 5.1e-35 121.3 1.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.25 MSTRG.26811.3_3 - 2.5e-07 31.2 0.0 5.5e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter PRA1 PF03208.17 MSTRG.26811.3_3 - 1.9 8.0 7.2 4.9 6.6 1.6 2.5 1 1 1 2 2 2 0 PRA1 family protein WD40 PF00400.30 MSTRG.12671.1_1 - 1.8e-27 94.9 9.9 1.5e-06 28.6 0.0 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.12671.1_1 - 4.6e-14 52.3 3.7 1.9e-05 24.7 0.2 4.3 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 MSTRG.12671.1_1 - 0.00029 20.6 0.0 1.4 8.6 0.0 3.1 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.6 MSTRG.12671.1_1 - 0.042 12.3 0.2 0.072 11.6 0.2 1.3 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Ge1_WD40 PF16529.3 MSTRG.12671.1_1 - 0.08 11.8 0.0 0.19 10.6 0.0 1.7 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein F-box-like PF12937.5 MSTRG.13858.1_2 - 0.79 9.5 4.3 1.6 8.6 4.3 1.5 1 0 0 1 1 1 0 F-box-like START PF01852.17 MSTRG.9875.1_1 - 6.5e-20 71.3 0.0 8.4e-20 70.9 0.0 1.1 1 0 0 1 1 1 1 START domain zf-C3HC4_2 PF13923.4 MSTRG.14221.1_3 - 4e-08 32.8 18.0 4e-08 32.8 18.0 2.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.14221.1_3 - 7e-07 29.0 10.5 2.6e-06 27.2 10.5 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 MSTRG.14221.1_3 - 1.1e-06 28.7 18.5 1.1e-06 28.7 18.5 3.2 2 1 0 2 2 1 1 Ring finger domain zf-TRAF PF02176.16 MSTRG.14221.1_3 - 1.6e-06 28.6 5.0 1.6e-06 28.6 5.0 3.5 1 1 2 3 3 2 1 TRAF-type zinc finger zf-C3HC4 PF00097.23 MSTRG.14221.1_3 - 3e-06 26.9 18.1 1.4e-05 24.7 18.1 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 MSTRG.14221.1_3 - 4.5e-06 26.7 12.9 4.5e-06 26.7 12.9 2.5 3 0 0 3 3 2 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.4 MSTRG.14221.1_3 - 9.3e-06 25.3 19.3 9.3e-06 25.3 19.3 3.0 2 1 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) U-box PF04564.13 MSTRG.14221.1_3 - 0.00086 19.3 0.0 0.0017 18.4 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-C3HC4_4 PF15227.4 MSTRG.14221.1_3 - 0.0019 18.2 15.4 0.0019 18.2 15.4 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.4 MSTRG.14221.1_3 - 0.0097 15.7 17.7 0.0097 15.7 17.7 2.8 2 1 0 2 2 1 1 zinc-RING finger domain Dehydratase_MU PF02288.13 MSTRG.14221.1_3 - 0.19 11.5 0.2 0.33 10.7 0.2 1.3 1 0 0 1 1 1 0 Dehydratase medium subunit zf-Nse PF11789.6 MSTRG.14221.1_3 - 1.2 8.9 16.2 0.054 13.2 10.0 2.0 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit RNase_H2-Ydr279 PF09468.8 MSTRG.22368.1_3 - 3.5e-53 181.0 4.4 1e-52 179.5 4.4 1.7 1 1 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) Glycos_transf_2 PF00535.24 MSTRG.23229.1_2 - 1.4e-28 99.7 0.0 2.4e-28 98.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.20 MSTRG.23229.1_2 - 1.7e-22 79.9 3.1 2.8e-22 79.2 3.1 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.4 MSTRG.23229.1_2 - 5.7e-06 26.3 0.0 8.6e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.12 MSTRG.23229.1_2 - 0.00039 19.9 0.0 0.00082 18.8 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 MSTRG.23229.1_2 - 0.0043 16.4 0.0 0.0082 15.5 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 RicinB_lectin_2 PF14200.4 MSTRG.23229.1_2 - 0.018 15.7 0.3 1.7 9.3 0.0 2.7 1 1 2 3 3 3 0 Ricin-type beta-trefoil lectin domain-like CDtoxinA PF03498.12 MSTRG.23229.1_2 - 0.039 13.4 0.7 0.85 9.1 0.2 2.2 1 1 1 2 2 2 0 Cytolethal distending toxin A/C domain ICAP-1_inte_bdg PF10480.7 MSTRG.2127.1_3 - 5.6 6.8 11.8 26 4.6 12.5 1.7 1 1 1 2 2 2 0 Beta-1 integrin binding protein Cpn10 PF00166.19 MSTRG.26533.1_3 - 4.8e-29 100.1 0.0 5.9e-29 99.9 0.0 1.1 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit MACPF PF01823.17 MSTRG.12092.1_2 - 4.2e-37 128.1 0.0 8.6e-37 127.1 0.0 1.5 2 0 0 2 2 2 1 MAC/Perforin domain Ldl_recept_a PF00057.16 MSTRG.12092.1_2 - 1.8e-08 34.3 13.1 5.8e-08 32.7 13.1 2.0 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A IRS PF02174.15 MSTRG.18990.1_2 - 7.5e-08 32.1 0.0 1.5e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 PTB domain (IRS-1 type) PH PF00169.27 MSTRG.18990.1_2 - 0.05 14.0 0.0 0.14 12.6 0.0 1.7 1 0 0 1 1 1 0 PH domain DARPP-32 PF05395.10 MSTRG.2744.3_1 - 0.13 12.3 0.8 0.24 11.5 0.8 1.3 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 Kinesin PF00225.21 MSTRG.2744.3_3 - 8.4e-112 373.2 0.0 8.4e-112 373.2 0.0 2.9 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.3 MSTRG.2744.3_3 - 1e-21 77.3 2.8 1.3e-20 73.7 0.0 3.2 3 0 0 3 3 3 1 Microtubule binding Ribosomal_L23 PF00276.18 MSTRG.22119.2_3 - 3.8e-13 49.5 0.0 6.3e-13 48.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L23 GTP_EFTU PF00009.25 MSTRG.19325.1_3 - 5.2e-15 55.4 0.0 8.4e-15 54.7 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.23 MSTRG.19325.1_3 - 7.5e-07 29.3 1.6 4.3e-06 26.9 0.1 2.6 2 1 0 2 2 2 1 Elongation factor Tu domain 2 Mo25 PF08569.9 MSTRG.15954.3_1 - 2.3e-34 119.1 0.2 2.8e-34 118.8 0.2 1.0 1 0 0 1 1 1 1 Mo25-like MukF_M PF17192.2 MSTRG.15954.3_1 - 0.063 12.9 0.1 0.088 12.4 0.1 1.2 1 0 0 1 1 1 0 MukF middle domain DUF4825 PF16107.3 MSTRG.15954.3_1 - 0.13 12.3 0.1 0.2 11.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4825) DEAD PF00270.27 MSTRG.29326.1_3 - 1.7e-09 37.6 0.0 1.8e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.13 MSTRG.29326.1_3 - 0.00084 19.2 0.0 0.00095 19.1 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.18 MSTRG.29326.1_3 - 0.021 13.7 0.0 0.025 13.5 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_19 PF13245.4 MSTRG.29326.1_3 - 0.11 12.7 0.0 0.13 12.5 0.0 1.1 1 0 0 1 1 1 0 AAA domain GDA1_CD39 PF01150.15 MSTRG.4700.1_2 - 4e-41 141.0 0.5 1.8e-40 138.8 0.5 1.9 1 1 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.14 MSTRG.4700.1_2 - 0.087 12.1 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Ppx/GppA phosphatase family Calsequestrin PF01216.15 MSTRG.8161.7_1 - 1.9e-167 557.0 65.6 1.9e-166 553.7 65.6 2.0 1 1 0 1 1 1 1 Calsequestrin Thioredoxin_6 PF13848.4 MSTRG.8161.7_1 - 8.8e-19 68.0 8.2 8.4e-16 58.3 2.8 2.5 2 1 0 2 2 2 2 Thioredoxin-like domain SDA1 PF05285.10 MSTRG.8161.7_1 - 0.00075 18.9 20.2 0.0011 18.4 20.2 1.2 1 0 0 1 1 1 1 SDA1 CobT PF06213.10 MSTRG.8161.7_1 - 0.26 10.5 16.0 0.41 9.9 16.0 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TPR_14 PF13428.4 MSTRG.11149.3_2 - 2.1e-10 40.4 12.7 0.00013 22.4 0.0 7.1 6 1 2 8 8 7 3 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.11149.3_2 - 9.2e-10 38.5 6.8 2.9e-05 24.0 1.1 3.6 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.15 MSTRG.11149.3_2 - 2.7e-08 33.2 18.4 0.00088 19.1 0.0 6.9 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.11149.3_2 - 3.2e-06 26.6 5.1 0.02 14.6 0.0 6.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_9 PF13371.4 MSTRG.11149.3_2 - 5.2e-06 26.4 6.1 0.00081 19.4 0.1 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.11149.3_2 - 5.7e-06 26.0 3.1 0.00039 20.3 0.0 4.9 5 1 0 5 5 4 1 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.11149.3_2 - 6.9e-06 26.3 7.4 0.065 13.6 0.6 5.0 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.11149.3_2 - 1.4e-05 25.0 4.4 8.3 6.9 0.0 6.0 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.11149.3_2 - 2.6e-05 24.7 7.0 1.3 9.7 0.0 4.9 4 1 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.11149.3_2 - 9.7e-05 22.6 5.2 0.38 11.4 0.0 5.3 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_20 PF14561.4 MSTRG.11149.3_2 - 0.0032 17.6 7.2 4.3 7.6 0.3 4.0 3 1 1 4 4 3 1 Tetratricopeptide repeat DUF627 PF04781.10 MSTRG.11149.3_2 - 0.052 13.4 1.5 3.9 7.4 0.9 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF627) ChAPs PF09295.8 MSTRG.11149.3_2 - 0.062 12.2 0.5 0.34 9.7 0.0 2.0 2 0 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_11 PF13414.4 MSTRG.11149.3_2 - 0.075 12.6 2.3 0.68 9.5 0.0 3.7 5 1 0 5 5 5 0 TPR repeat TPR_7 PF13176.4 MSTRG.11149.3_2 - 0.59 10.2 7.0 24 5.2 0.0 5.3 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.11149.3_2 - 3.4 7.5 6.8 7.6 6.4 0.1 4.0 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.11149.3_2 - 8.7 6.6 19.3 3.1 8.0 0.1 5.0 5 1 0 5 5 5 0 Tetratricopeptide repeat WT1 PF02165.13 MSTRG.23184.1_1 - 1.5e-140 467.5 7.0 2.3e-140 466.9 7.0 1.3 1 0 0 1 1 1 1 Wilm's tumour protein zf-H2C2_2 PF13465.4 MSTRG.23184.1_1 - 2.3e-16 59.3 28.7 6.5e-07 29.4 2.3 5.1 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.23184.1_1 - 1.3e-13 50.4 42.9 3.3e-06 27.1 1.6 5.6 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.23184.1_1 - 0.00021 21.7 37.3 0.0015 19.1 0.9 5.6 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.23184.1_1 - 0.00042 20.4 6.6 0.014 15.6 0.7 3.8 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.23184.1_1 - 0.0005 20.2 2.6 0.0005 20.2 2.6 4.3 4 0 0 4 4 4 1 Zinc-finger of C2H2 type Ogr_Delta PF04606.10 MSTRG.23184.1_1 - 0.2 11.5 4.6 0.52 10.2 0.5 3.4 2 1 0 2 2 2 0 Ogr/Delta-like zinc finger FOXP-CC PF16159.3 MSTRG.23184.1_1 - 0.28 11.7 9.1 0.25 11.8 0.4 3.3 2 1 2 4 4 4 0 FOXP coiled-coil domain C1-set PF07654.13 MSTRG.23184.1_1 - 1.2 9.5 4.8 6.3 7.2 0.1 2.7 3 0 0 3 3 3 0 Immunoglobulin C1-set domain zf-C2HC_2 PF13913.4 MSTRG.23184.1_1 - 3.5 7.5 12.2 13 5.7 0.5 3.7 3 0 0 3 3 3 0 zinc-finger of a C2HC-type Bromodomain PF00439.23 MSTRG.27701.1_2 - 1.1e-42 143.9 1.2 9.4e-21 73.6 0.0 2.4 2 0 0 2 2 2 2 Bromodomain BET PF17035.3 MSTRG.27701.1_2 - 1.7e-28 98.5 0.2 3.5e-28 97.4 0.2 1.6 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation BRD4_CDT PF17105.3 MSTRG.27701.1_2 - 4e-24 83.8 11.9 4e-24 83.8 11.9 3.9 4 0 0 4 4 4 1 C-terminal domain of bromodomain protein 4 Rho_Binding PF08912.9 MSTRG.8351.2_1 - 5.6e-24 84.6 13.3 5.6e-24 84.6 13.3 9.1 4 1 4 8 8 8 1 Rho Binding PH PF00169.27 MSTRG.8351.2_1 - 1e-06 29.1 0.1 0.0011 19.4 0.0 3.1 2 0 0 2 2 2 2 PH domain C1_1 PF00130.20 MSTRG.8351.2_1 - 0.0025 17.5 5.3 0.0025 17.5 5.3 2.2 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SIR2 PF02146.15 MSTRG.12776.2_2 - 3.3e-44 150.8 0.0 4.8e-44 150.2 0.0 1.3 1 0 0 1 1 1 1 Sir2 family PNTB PF02233.14 MSTRG.12776.2_2 - 0.033 13.0 0.0 0.12 11.1 0.0 1.7 2 0 0 2 2 2 0 NAD(P) transhydrogenase beta subunit TPP_enzyme_M PF00205.20 MSTRG.12776.2_2 - 0.16 11.6 0.0 4.2 7.0 0.0 2.3 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain DUF719 PF05334.11 MSTRG.11388.1_2 - 2.7e-43 148.3 7.8 2.7e-43 148.3 7.8 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF719) CAMSAP_CH PF11971.6 MSTRG.16897.1_1 - 5.8e-33 112.5 0.2 1.1e-32 111.6 0.2 1.5 1 0 0 1 1 1 1 CAMSAP CH domain CH PF00307.29 MSTRG.16897.1_1 - 4.7e-05 23.4 0.0 8.9e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain Carb_anhydrase PF00194.19 MSTRG.29231.1_1 - 1.4e-11 44.3 0.1 1.7e-11 44.0 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Ribonuc_red_sm PF00268.19 MSTRG.29231.1_1 - 0.023 14.1 0.3 0.03 13.7 0.3 1.1 1 0 0 1 1 1 0 Ribonucleotide reductase, small chain Pkinase PF00069.23 MSTRG.17457.1_3 - 2.5e-69 233.4 0.0 3.8e-69 232.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.17457.1_3 - 2.7e-24 85.7 0.0 4.7e-24 84.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 MSTRG.17457.1_3 - 0.011 15.6 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ole-e-6 PF09253.8 MSTRG.17457.1_3 - 0.017 14.9 2.2 0.53 10.1 0.6 3.3 3 0 0 3 3 3 0 Pollen allergen ole e 6 TPR_11 PF13414.4 MSTRG.9931.1_1 - 0.00022 20.7 0.6 0.045 13.3 0.1 2.9 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.15 MSTRG.9931.1_1 - 0.0027 17.6 4.7 0.57 10.3 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.9931.1_1 - 0.017 15.5 0.1 0.057 13.8 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.9931.1_1 - 0.24 11.2 3.5 32 4.4 0.3 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat zf-C3HC4_3 PF13920.4 MSTRG.22528.1_2 - 3.5e-08 33.1 10.7 8.8e-08 31.8 10.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 MSTRG.22528.1_2 - 4.2e-06 26.4 15.0 1.1e-05 25.0 15.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.22528.1_2 - 1.6e-05 24.9 14.4 1.6e-05 24.9 14.4 2.2 2 0 0 2 2 2 1 Ring finger domain Prok-RING_4 PF14447.4 MSTRG.22528.1_2 - 9.9e-05 22.0 11.2 0.00037 20.2 11.2 2.0 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.23 MSTRG.22528.1_2 - 0.00012 21.7 15.0 0.00032 20.4 15.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 MSTRG.22528.1_2 - 0.011 15.9 9.5 0.032 14.4 9.5 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.4 MSTRG.22528.1_2 - 0.012 15.5 12.3 0.039 13.8 12.3 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.4 MSTRG.22528.1_2 - 0.058 13.2 19.2 0.038 13.8 14.0 3.1 2 1 1 3 3 3 0 zinc-RING finger domain zf-RING_11 PF17123.3 MSTRG.22528.1_2 - 0.42 10.2 9.6 1.2 8.8 9.6 1.9 1 0 0 1 1 1 0 RING-like zinc finger GSHPx PF00255.17 MSTRG.24901.1_3 - 5.4e-39 132.0 0.0 8.1e-39 131.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.19 MSTRG.24901.1_3 - 0.0033 17.2 0.0 0.017 14.9 0.0 2.0 1 1 0 1 1 1 1 AhpC/TSA family TEA PF01285.16 MSTRG.20262.3_2 - 2.8e-26 92.5 0.0 4.2e-26 92.0 0.0 1.1 1 0 0 1 1 1 1 TEA/ATTS domain family adh_short PF00106.23 MSTRG.6775.1_1 - 2.5e-33 115.0 0.1 2.2e-25 89.2 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.4 MSTRG.6775.1_1 - 2.5e-24 86.0 0.1 4.7e-17 62.2 0.1 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 MSTRG.6775.1_1 - 3e-06 27.1 0.1 4.8e-06 26.5 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.19 MSTRG.6775.1_1 - 0.0018 17.6 0.1 0.0027 17.1 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.16 MSTRG.6775.1_1 - 0.029 14.5 0.3 0.13 12.4 0.3 2.0 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Pkinase PF00069.23 MSTRG.6181.1_1 - 1.6e-71 240.7 0.0 2.4e-71 240.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.6181.1_1 - 5.1e-52 176.6 0.0 7.8e-52 176.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Mst1_SARAH PF11629.6 MSTRG.6181.1_1 - 7.7e-25 86.6 4.0 1.8e-24 85.4 4.0 1.7 1 0 0 1 1 1 1 C terminal SARAH domain of Mst1 CKAP2_C PF15297.4 MSTRG.6181.1_1 - 1.1 8.1 9.0 0.43 9.5 6.4 1.6 1 1 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus DUF2870 PF11069.6 MSTRG.6181.1_1 - 3.5 7.9 7.2 0.13 12.5 0.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2870) Cadherin PF00028.15 MSTRG.26138.1_1 - 2.6e-32 111.0 0.0 3.9e-22 78.4 0.0 2.1 2 0 0 2 2 2 2 Cadherin domain Cadherin_2 PF08266.10 MSTRG.26138.1_1 - 0.0078 15.9 0.0 2.2 8.0 0.0 2.3 2 0 0 2 2 2 2 Cadherin-like HLH PF00010.24 MSTRG.22047.1_3 - 2.1e-10 40.3 0.7 2.1e-10 40.3 0.7 2.1 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.11 MSTRG.22047.1_3 - 6.1e-10 39.0 0.2 1.6e-09 37.7 0.2 1.8 1 0 0 1 1 1 1 Hairy Orange BTB PF00651.29 MSTRG.13720.1_3 - 2.3e-28 98.5 0.1 2.1e-20 72.9 0.5 2.5 2 0 0 2 2 2 2 BTB/POZ domain BACK PF07707.13 MSTRG.13720.1_3 - 0.14 12.1 1.5 0.6 10.1 0.1 2.2 2 0 0 2 2 2 0 BTB And C-terminal Kelch Cast PF10174.7 MSTRG.11670.5_3 - 5.2e-57 193.5 23.0 6.7e-57 193.1 23.0 1.1 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone RBD-FIP PF09457.8 MSTRG.11670.5_3 - 1e-07 31.6 2.6 1.5e-07 31.1 0.5 2.5 2 0 0 2 2 2 1 FIP domain SepSecS PF05889.11 MSTRG.11670.5_3 - 0.5 8.9 2.5 0.72 8.3 2.5 1.1 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS IncA PF04156.12 MSTRG.11670.5_3 - 2 8.0 21.5 7.3 6.2 0.2 2.3 2 0 0 2 2 2 0 IncA protein FAM76 PF16046.3 MSTRG.11670.5_3 - 2 7.5 16.6 0.46 9.7 11.9 2.0 1 1 1 2 2 2 0 FAM76 protein Fez1 PF06818.13 MSTRG.11670.5_3 - 5.3 7.3 18.0 1.7 8.9 14.7 1.6 1 1 0 1 1 1 0 Fez1 HIP1_clath_bdg PF16515.3 MSTRG.11670.5_3 - 5.3 7.6 21.8 0.63 10.6 3.5 3.1 3 1 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 zf-C4H2 PF10146.7 MSTRG.11670.5_3 - 6.2 6.9 17.1 3.1 7.9 14.1 1.9 1 1 1 2 2 2 0 Zinc finger-containing protein PIN_4 PF13638.4 MSTRG.11670.5_3 - 9.2 6.5 7.6 50 4.1 7.6 2.1 1 1 0 1 1 1 0 PIN domain DUF3384 PF11864.6 MSTRG.18960.1_2 - 4.8e-20 71.8 0.1 5.7e-20 71.6 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3384) PIP49_C PF12260.6 MSTRG.9225.2_3 - 2.1e-56 190.4 0.3 3.5e-56 189.7 0.0 1.5 2 0 0 2 2 2 1 Protein-kinase domain of FAM69 PIP49_N PF14875.4 MSTRG.9225.2_3 - 3e-52 176.5 0.0 4.8e-52 175.8 0.0 1.3 1 0 0 1 1 1 1 N-term cysteine-rich ER, FAM69 EF-hand_1 PF00036.30 MSTRG.9225.2_3 - 0.00088 18.5 0.0 0.0059 15.9 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.4 MSTRG.9225.2_3 - 0.076 12.4 0.3 0.2 11.1 0.0 1.8 2 0 0 2 2 2 0 EF hand EF-hand_8 PF13833.4 MSTRG.9225.2_3 - 0.091 12.4 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair Cupin_8 PF13621.4 MSTRG.1307.1_3 - 1.4e-77 260.8 0.0 1.8e-77 260.4 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.20 MSTRG.1307.1_3 - 0.039 14.3 0.0 0.091 13.1 0.0 1.5 1 0 0 1 1 1 0 JmjC domain, hydroxylase Methyltransf_25 PF13649.4 MSTRG.15827.1_1 - 1.7e-21 76.6 0.4 3e-19 69.4 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.10 MSTRG.15827.1_1 - 2e-20 73.1 0.3 5.9e-19 68.4 0.0 2.7 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.4 MSTRG.15827.1_1 - 4.2e-16 59.0 0.6 2.1e-13 50.2 0.0 3.1 3 1 1 4 4 4 1 Methyltransferase domain Methyltransf_23 PF13489.4 MSTRG.15827.1_1 - 9.9e-14 51.5 0.5 1.2e-10 41.5 0.1 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_PK PF05891.10 MSTRG.15827.1_1 - 5.8e-12 45.5 0.1 1.6e-11 44.1 0.0 1.7 2 0 0 2 2 2 1 AdoMet dependent proline di-methyltransferase Methyltransf_12 PF08242.10 MSTRG.15827.1_1 - 2.3e-11 44.2 2.2 1.7e-10 41.3 0.0 2.8 3 0 0 3 3 3 1 Methyltransferase domain RrnaAD PF00398.18 MSTRG.15827.1_1 - 4.4e-11 42.2 0.0 3.4e-08 32.8 0.0 2.4 2 0 0 2 2 2 2 Ribosomal RNA adenine dimethylase TehB PF03848.12 MSTRG.15827.1_1 - 9.8e-11 41.3 0.0 1.8e-07 30.6 0.0 2.3 2 1 0 2 2 2 2 Tellurite resistance protein TehB NodS PF05401.9 MSTRG.15827.1_1 - 4.6e-10 39.3 0.0 1.1e-09 38.1 0.0 1.6 1 0 0 1 1 1 1 Nodulation protein S (NodS) Ubie_methyltran PF01209.16 MSTRG.15827.1_1 - 9e-09 34.9 0.0 5.9e-07 28.9 0.0 2.2 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family MTS PF05175.12 MSTRG.15827.1_1 - 2.5e-07 30.2 0.0 0.00077 18.9 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase small domain CMAS PF02353.18 MSTRG.15827.1_1 - 3.1e-07 29.8 0.2 0.0023 17.2 0.0 2.2 2 0 0 2 2 2 2 Mycolic acid cyclopropane synthetase PCMT PF01135.17 MSTRG.15827.1_1 - 9e-07 28.7 0.0 0.011 15.4 0.0 2.3 2 0 0 2 2 2 2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CheR PF01739.16 MSTRG.15827.1_1 - 1.6e-05 24.3 0.0 8.1e-05 22.1 0.0 2.0 2 0 0 2 2 2 1 CheR methyltransferase, SAM binding domain FtsJ PF01728.17 MSTRG.15827.1_1 - 0.0011 19.0 0.0 0.019 14.9 0.0 2.2 2 0 0 2 2 2 1 FtsJ-like methyltransferase PrmA PF06325.11 MSTRG.15827.1_1 - 0.0019 17.5 0.0 2.3 7.4 0.0 2.4 2 0 0 2 2 2 2 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_2 PF00891.16 MSTRG.15827.1_1 - 0.01 14.9 0.1 0.059 12.4 0.0 2.0 2 0 0 2 2 2 0 O-methyltransferase MetW PF07021.10 MSTRG.15827.1_1 - 0.028 13.9 0.1 7.9 5.9 0.1 2.2 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW Iso_dh PF00180.18 MSTRG.15827.1_1 - 0.036 13.1 0.0 0.056 12.4 0.0 1.2 1 0 0 1 1 1 0 Isocitrate/isopropylmalate dehydrogenase Bin3 PF06859.10 MSTRG.15827.1_1 - 0.13 12.8 2.2 0.51 10.9 0.4 2.7 2 1 1 3 3 2 0 Bicoid-interacting protein 3 (Bin3) Atrophin-1 PF03154.13 MSTRG.15827.1_1 - 0.6 8.2 11.3 0.74 7.9 11.3 1.0 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.4 MSTRG.15827.1_1 - 2.5 8.0 10.6 0.098 12.5 4.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) HSP70 PF00012.18 MSTRG.7543.1_1 - 2.4e-20 72.1 0.1 2.7e-20 72.0 0.1 1.0 1 0 0 1 1 1 1 Hsp70 protein DUF1062 PF06353.10 MSTRG.7543.1_1 - 0.029 15.1 0.1 0.063 14.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1062) EF-hand_7 PF13499.4 MSTRG.17611.1_2 - 4.4e-14 52.6 0.1 1e-06 29.0 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 MSTRG.17611.1_2 - 2e-11 42.4 0.7 0.00018 20.7 0.1 4.3 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.4 MSTRG.17611.1_2 - 5.3e-10 38.3 0.2 0.00021 20.9 0.1 3.8 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.4 MSTRG.17611.1_2 - 4.4e-09 35.8 0.1 6.6e-06 25.7 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.4 MSTRG.17611.1_2 - 2.4e-06 27.7 0.0 6e-05 23.2 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain GPHH PF16905.3 MSTRG.17611.1_2 - 0.0015 18.2 0.0 0.0042 16.7 0.0 1.7 2 0 0 2 2 2 1 Voltage-dependent L-type calcium channel, IQ-associated EF-hand_5 PF13202.4 MSTRG.17611.1_2 - 0.045 13.2 0.1 0.67 9.4 0.0 2.5 2 0 0 2 2 2 0 EF hand FlgD PF03963.12 MSTRG.17611.1_2 - 0.049 13.8 0.2 0.12 12.5 0.1 1.6 2 0 0 2 2 2 0 Flagellar hook capping protein - N-terminal region Kinesin PF00225.21 MSTRG.21578.3_3 - 6.8e-99 330.8 0.0 9.2e-99 330.4 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 MSTRG.21578.3_3 - 1.1e-39 135.7 0.0 2.7e-37 127.9 0.0 2.3 2 0 0 2 2 2 1 Microtubule binding DUF972 PF06156.11 MSTRG.21578.3_3 - 0.026 15.0 6.0 3.4 8.2 0.1 4.5 4 1 1 5 5 4 0 Protein of unknown function (DUF972) TSC22 PF01166.16 MSTRG.21578.3_3 - 0.055 13.7 0.4 17 5.7 0.1 3.2 3 0 0 3 3 3 0 TSC-22/dip/bun family Spc7 PF08317.9 MSTRG.21578.3_3 - 0.29 9.8 6.1 3.8 6.2 0.2 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein End3 PF12761.5 MSTRG.21578.3_3 - 0.36 10.8 4.8 0.73 9.8 4.8 1.4 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 CENP-F_leu_zip PF10473.7 MSTRG.21578.3_3 - 0.47 10.3 5.7 1.2 9.0 0.6 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF87 PF01935.15 MSTRG.21578.3_3 - 0.68 9.8 1.9 3.2 7.6 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF87 APG6 PF04111.10 MSTRG.21578.3_3 - 1.1 8.4 5.6 1.8 7.7 5.6 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4407 PF14362.4 MSTRG.21578.3_3 - 1.8 7.7 7.5 11 5.1 7.5 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) HrpB7 PF09486.8 MSTRG.21578.3_3 - 1.8 8.8 20.3 0.56 10.4 0.9 3.4 1 1 2 3 3 3 0 Bacterial type III secretion protein (HrpB7) Filament PF00038.19 MSTRG.21578.3_3 - 3.2 7.1 15.2 4.8 6.5 1.3 2.5 1 1 0 2 2 2 0 Intermediate filament protein HIP1_clath_bdg PF16515.3 MSTRG.21578.3_3 - 3.5 8.2 9.7 0.85 10.1 1.1 3.0 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 ADIP PF11559.6 MSTRG.21578.3_3 - 4.6 7.2 12.8 8.8 6.3 1.9 2.9 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding SlyX PF04102.10 MSTRG.21578.3_3 - 4.7 7.8 10.6 1.9 9.1 5.2 3.3 3 1 0 3 3 3 0 SlyX Exonuc_VII_L PF02601.13 MSTRG.21578.3_3 - 5.1 6.4 9.7 11 5.3 9.7 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit CYLD_phos_site PF16607.3 MSTRG.5443.3_1 - 7.5e-35 120.1 14.2 4.2e-31 107.9 7.2 2.4 1 1 1 2 2 2 2 Phosphorylation region of CYLD, unstructured CAP_GLY PF01302.23 MSTRG.5443.3_1 - 5.3e-33 112.7 0.1 1.3e-13 50.6 0.0 3.4 3 0 0 3 3 3 3 CAP-Gly domain UCH PF00443.27 MSTRG.5443.3_1 - 4.4e-05 23.0 0.0 8e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase WGR PF05406.13 MSTRG.27746.1_1 - 0.082 12.8 0.3 0.15 12.0 0.3 1.4 1 0 0 1 1 1 0 WGR domain DUF4643 PF15485.4 MSTRG.5884.1_2 - 4.7e-47 161.0 9.4 7.9e-47 160.3 9.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4643) Ribosomal_60s PF00428.17 MSTRG.999.2_3 - 0.13 12.7 6.0 0.24 11.8 6.0 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein GREB1 PF15782.3 MSTRG.2103.1_1 - 7.6e-264 878.8 3.9 8.5e-264 878.6 3.9 1.0 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer Arm PF00514.21 MSTRG.15780.3_3 - 3.8e-09 36.1 10.8 1.7e-05 24.5 0.0 5.0 6 0 0 6 6 6 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.4 MSTRG.15780.3_3 - 0.014 15.8 0.1 0.31 11.4 0.0 2.5 2 0 0 2 2 2 0 HEAT-like repeat MutL PF13941.4 MSTRG.24516.1_2 - 0.21 10.0 0.0 0.26 9.7 0.0 1.1 1 0 0 1 1 1 0 MutL protein NUDIX PF00293.26 MSTRG.25150.1_2 - 9.7e-10 38.5 0.0 2.6e-09 37.1 0.0 1.8 2 1 0 2 2 2 1 NUDIX domain CitMHS PF03600.14 MSTRG.24013.1_1 - 3.6e-09 36.1 3.3 4.2e-09 35.9 3.3 1.1 1 0 0 1 1 1 1 Citrate transporter Mito_carr PF00153.25 MSTRG.2692.1_3 - 5e-64 212.1 3.8 5.7e-26 90.1 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1430 PF07242.9 MSTRG.8721.1_1 - 0.46 10.6 5.3 0.22 11.6 1.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1430) TMEM214 PF10151.7 MSTRG.19962.2_1 - 1.6e-247 823.1 6.3 1.9e-247 822.9 6.3 1.0 1 0 0 1 1 1 1 TMEM214, C-terminal, caspase 4 activator NADH_dh_m_C1 PF15088.4 MSTRG.5991.2_3 - 6.4e-12 44.8 0.1 1.2e-11 43.9 0.1 1.4 1 0 0 1 1 1 1 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial MRP-S34 PF16053.3 MSTRG.6433.1_2 - 3e-43 146.6 0.2 4.4e-43 146.0 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S34 Hydrolase PF00702.24 MSTRG.20403.1_3 - 2.4e-60 204.3 0.5 4.1e-60 203.5 0.5 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.18 MSTRG.20403.1_3 - 6.6e-58 195.5 1.9 6.6e-58 195.5 1.9 2.1 2 0 0 2 2 2 1 E1-E2 ATPase HMA PF00403.24 MSTRG.20403.1_3 - 1.5e-52 175.8 4.0 1.6e-11 44.3 0.0 5.9 6 0 0 6 6 6 4 Heavy-metal-associated domain Hydrolase_3 PF08282.10 MSTRG.20403.1_3 - 1.3e-06 28.2 1.6 0.00038 20.1 0.2 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.5 MSTRG.20403.1_3 - 0.00056 20.2 0.1 0.0011 19.3 0.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.4 MSTRG.20403.1_3 - 0.01 15.8 0.1 0.11 12.5 0.1 2.9 4 0 0 4 4 4 0 Haloacid dehalogenase-like hydrolase HAD_2 PF13419.4 MSTRG.20403.1_3 - 0.031 14.2 0.0 0.068 13.1 0.0 1.5 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DUF3247 PF11607.6 MSTRG.20403.1_3 - 0.057 13.2 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3247) DUF2997 PF11211.6 MSTRG.20403.1_3 - 0.19 11.4 1.0 16 5.3 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2997) Spore_YhcN_YlaJ PF09580.8 MSTRG.20403.1_3 - 0.19 11.7 0.0 0.37 10.7 0.0 1.4 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) zf-Tim10_DDP PF02953.13 MSTRG.19147.1_1 - 2.9e-21 74.8 0.1 2.9e-21 74.8 0.1 2.5 2 0 0 2 2 2 1 Tim10/DDP family zinc finger Myosin_tail_1 PF01576.17 MSTRG.19019.4_1 - 0 1673.5 307.2 0 1673.3 307.2 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.19 MSTRG.19019.4_1 - 7.9e-303 1005.7 5.0 7.9e-303 1005.7 5.0 2.9 3 0 0 3 3 3 1 Myosin head (motor domain) Myosin_N PF02736.17 MSTRG.19019.4_1 - 6.5e-15 54.5 0.3 1.7e-14 53.2 0.3 1.8 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain ADIP PF11559.6 MSTRG.19019.4_1 - 0.00019 21.4 13.9 0.00019 21.4 13.9 13.9 1 1 14 15 15 15 1 Afadin- and alpha -actinin-Binding CC2-LZ PF16516.3 MSTRG.19019.4_1 - 0.0019 18.4 11.6 0.0019 18.4 11.6 16.9 4 3 13 17 17 17 2 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator IQ PF00612.25 MSTRG.19019.4_1 - 0.0084 15.7 0.9 0.032 13.9 0.9 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif AAA_22 PF13401.4 MSTRG.19019.4_1 - 0.17 12.0 0.0 0.17 12.0 0.0 6.1 8 0 0 8 8 8 0 AAA domain AAA_16 PF13191.4 MSTRG.19019.4_1 - 0.94 9.7 0.0 0.94 9.7 0.0 6.2 4 2 0 4 4 4 0 AAA ATPase domain Ets PF00178.20 MSTRG.3622.1_1 - 4.3e-35 119.9 0.6 9.1e-35 118.9 0.6 1.6 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.14 MSTRG.3622.1_1 - 5.1e-23 80.7 0.2 9.1e-23 79.9 0.2 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_2 PF07647.15 MSTRG.3622.1_1 - 3.6 7.6 5.3 0.58 10.2 0.3 2.2 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) Homeobox PF00046.27 MSTRG.24676.1_1 - 7.1e-20 70.5 3.3 1.1e-19 69.8 3.3 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 MSTRG.24676.1_1 - 3.1e-05 23.6 0.6 3.1e-05 23.6 0.6 2.0 2 0 0 2 2 2 1 Homeobox KN domain Homez PF11569.6 MSTRG.24676.1_1 - 0.00063 19.0 0.1 0.0015 17.8 0.1 1.6 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez HTH_31 PF13560.4 MSTRG.24676.1_1 - 0.011 15.9 0.0 0.025 14.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain TNFR_c6 PF00020.16 MSTRG.1699.4_2 - 1e-09 38.5 41.9 2.3e-08 34.2 2.8 4.4 5 0 0 5 5 5 3 TNFR/NGFR cysteine-rich region Y_phosphatase PF00102.25 MSTRG.25451.1_1 - 3.2e-81 272.2 0.0 6.4e-81 271.2 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.18 MSTRG.25451.1_1 - 0.0041 16.8 0.0 0.015 15.0 0.0 1.9 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Carb_anhydrase PF00194.19 MSTRG.25451.1_2 - 5.1e-69 232.5 0.0 5.1e-69 232.5 0.0 1.8 2 0 0 2 2 2 1 Eukaryotic-type carbonic anhydrase GUN4_N PF16416.3 MSTRG.25451.1_2 - 0.017 15.0 0.1 0.035 14.0 0.1 1.4 1 0 0 1 1 1 0 ARM-like repeat domain, GUN4-N terminal PrmA PF06325.11 MSTRG.4553.1_2 - 3.3e-06 26.6 1.0 3.3e-05 23.3 0.3 2.0 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.5 MSTRG.4553.1_2 - 0.002 18.0 0.1 0.0035 17.2 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 MSTRG.4553.1_2 - 0.0062 17.1 0.0 0.019 15.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.13 MSTRG.4553.1_2 - 0.032 13.7 0.0 0.055 13.0 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 I-set PF07679.14 MSTRG.24780.1_1 - 3e-171 555.9 4.2 4.6e-18 64.9 0.0 15.5 15 0 0 15 15 15 15 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.24780.1_1 - 2e-136 444.7 4.0 2.3e-11 44.0 0.0 15.2 15 0 0 15 15 15 14 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.24780.1_1 - 1.6e-96 316.7 0.6 2.7e-07 30.7 0.0 14.7 12 2 3 15 15 15 13 Immunoglobulin domain ig PF00047.23 MSTRG.24780.1_1 - 7.8e-86 282.2 5.3 5.7e-06 26.3 0.0 15.1 14 0 0 14 14 14 14 Immunoglobulin domain V-set PF07686.15 MSTRG.24780.1_1 - 6.8e-39 132.3 33.5 0.0047 16.9 0.0 22.0 17 9 3 20 20 20 9 Immunoglobulin V-set domain Izumo-Ig PF16706.3 MSTRG.24780.1_1 - 7.1e-19 67.5 11.1 0.05 13.5 0.0 12.2 13 0 0 13 13 13 5 Izumo-like Immunoglobulin domain C2-set_2 PF08205.10 MSTRG.24780.1_1 - 3.7e-12 46.0 4.1 0.31 11.0 0.0 10.4 12 0 0 12 12 12 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 MSTRG.24780.1_1 - 2.1e-07 31.2 10.1 6.3 7.2 0.0 10.7 13 0 0 13 13 13 1 Immunoglobulin C1-set domain Lep_receptor_Ig PF06328.9 MSTRG.24780.1_1 - 0.083 12.8 0.2 54 3.8 0.0 5.4 7 0 0 7 7 7 0 Ig-like C2-type domain fn3 PF00041.19 MSTRG.24780.1_1 - 0.13 12.5 0.0 0.52 10.5 0.0 2.0 1 0 0 1 1 1 0 Fibronectin type III domain LRR_4 PF12799.5 MSTRG.16764.1_2 - 2.3e-14 53.1 25.1 4.5e-05 23.6 0.2 4.4 1 1 6 7 7 7 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 MSTRG.16764.1_2 - 3.1e-14 52.4 13.1 1.1e-05 25.0 3.2 3.6 1 1 3 4 4 4 4 Leucine rich repeat LRR_1 PF00560.31 MSTRG.16764.1_2 - 0.1 13.0 12.2 23 5.8 0.1 6.3 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_6 PF13516.4 MSTRG.16764.1_2 - 0.67 10.0 10.6 61 3.9 0.5 5.6 6 0 0 6 6 6 0 Leucine Rich repeat TPR_12 PF13424.4 MSTRG.21189.1_2 - 7.2e-60 199.1 24.6 5e-19 68.2 2.1 3.9 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.21189.1_2 - 7.6e-56 184.5 11.2 7.5e-16 57.3 0.0 5.6 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.21189.1_2 - 3.8e-27 92.1 16.2 4.2e-06 26.3 0.3 6.1 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.21189.1_2 - 1.5e-24 84.6 26.7 4.2e-07 29.4 0.2 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.21189.1_2 - 5.8e-18 63.4 24.5 0.0008 19.2 1.8 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.21189.1_2 - 2.7e-14 52.0 18.2 0.0069 16.4 0.1 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.21189.1_2 - 2.1e-12 47.2 7.5 4.9e-05 23.6 0.8 3.5 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.21189.1_2 - 1.6e-11 44.6 6.4 0.0023 18.4 1.5 4.8 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.21189.1_2 - 3.2e-10 39.8 7.5 0.5 11.2 0.3 6.0 3 1 3 6 6 5 1 Tetratricopeptide repeat ANAPC3 PF12895.5 MSTRG.21189.1_2 - 1.5e-07 31.4 10.3 0.0049 16.9 0.1 3.5 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.4 MSTRG.21189.1_2 - 4.1e-07 29.8 8.9 0.12 12.6 0.4 5.0 5 0 0 5 5 4 2 Tetratricopeptide repeat SNAP PF14938.4 MSTRG.21189.1_2 - 4.9e-07 29.3 2.4 4.9e-07 29.3 2.4 1.6 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_4 PF07721.12 MSTRG.21189.1_2 - 3.7e-05 23.8 0.0 32 5.4 0.0 5.8 6 0 0 6 6 5 0 Tetratricopeptide repeat PPR PF01535.18 MSTRG.21189.1_2 - 0.00017 21.5 0.4 0.091 12.9 0.0 3.9 5 0 0 5 5 3 1 PPR repeat Cast PF10174.7 MSTRG.21189.1_2 - 0.0087 14.2 2.8 0.017 13.3 2.8 1.4 1 1 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone FAT PF02259.21 MSTRG.21189.1_2 - 0.0094 15.1 0.7 0.026 13.6 0.2 2.0 2 1 0 2 2 2 1 FAT domain PPR_2 PF13041.4 MSTRG.21189.1_2 - 0.013 15.5 0.6 1.7 8.8 0.0 3.1 3 0 0 3 3 2 0 PPR repeat family DUF627 PF04781.10 MSTRG.21189.1_2 - 0.015 15.1 4.0 3.5 7.6 0.0 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF627) HALZ PF02183.16 MSTRG.21189.1_2 - 0.026 14.6 1.7 0.13 12.4 1.1 2.5 1 1 1 2 2 2 0 Homeobox associated leucine zipper TMF_TATA_bd PF12325.6 MSTRG.21189.1_2 - 0.043 13.9 8.1 0.029 14.4 4.8 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding SHNi-TPR PF10516.7 MSTRG.21189.1_2 - 0.05 12.9 1.7 9.4 5.7 0.1 3.7 3 0 0 3 3 3 0 SHNi-TPR RPN7 PF10602.7 MSTRG.21189.1_2 - 0.055 13.0 3.4 1.8 8.1 0.5 3.3 1 1 2 3 3 3 0 26S proteasome subunit RPN7 DUF4919 PF16266.3 MSTRG.21189.1_2 - 0.094 12.5 0.5 1.2 8.9 0.1 2.8 1 1 3 4 4 4 0 Domain of unknown function (DUF4919) DUF5112 PF17139.2 MSTRG.21189.1_2 - 0.11 11.9 2.3 2.7 7.3 0.4 3.1 1 1 1 3 3 3 0 Domain of unknown function (DUF5112) JIP_LZII PF16471.3 MSTRG.21189.1_2 - 0.14 12.3 2.1 0.38 10.8 2.1 1.8 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II TPR_11 PF13414.4 MSTRG.21189.1_2 - 0.15 11.7 13.9 0.059 12.9 0.8 4.6 4 0 0 4 4 4 0 TPR repeat MIT PF04212.16 MSTRG.21189.1_2 - 0.16 12.0 10.3 88 3.2 0.0 5.2 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain NUDE_C PF04880.11 MSTRG.21189.1_2 - 0.2 12.0 3.4 0.13 12.6 1.4 1.7 2 0 0 2 2 1 0 NUDE protein, C-terminal conserved region DUF972 PF06156.11 MSTRG.21189.1_2 - 0.23 12.0 8.7 0.44 11.1 3.3 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF972) IncA PF04156.12 MSTRG.21189.1_2 - 0.27 10.8 2.8 0.58 9.8 2.8 1.5 1 0 0 1 1 1 0 IncA protein TMF_DNA_bd PF12329.6 MSTRG.21189.1_2 - 0.28 11.1 6.1 0.14 12.0 3.1 2.2 2 0 0 2 2 1 0 TATA element modulatory factor 1 DNA binding TPR_6 PF13174.4 MSTRG.21189.1_2 - 0.34 11.5 14.1 0.23 12.0 0.6 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat COG2 PF06148.9 MSTRG.21189.1_2 - 0.34 10.8 5.2 0.22 11.5 2.3 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 ADIP PF11559.6 MSTRG.21189.1_2 - 0.45 10.4 10.0 0.026 14.5 3.7 2.1 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding TPR_3 PF07720.10 MSTRG.21189.1_2 - 0.97 9.4 14.5 0.63 10.0 0.7 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat Wzy_C_2 PF11846.6 MSTRG.21189.1_2 - 1.4 8.7 3.6 7.4 6.3 0.1 3.2 2 2 1 4 4 4 0 Virulence factor membrane-bound polymerase, C-terminal DUF4404 PF14357.4 MSTRG.21189.1_2 - 2.9 8.5 7.7 6.9 7.3 0.1 3.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4404) ZapB PF06005.10 MSTRG.21189.1_2 - 5.2 7.5 9.8 1 9.7 4.4 2.6 2 1 1 3 3 2 0 Cell division protein ZapB ATG16 PF08614.9 MSTRG.21189.1_2 - 8.1 6.4 19.4 0.56 10.2 8.5 3.3 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) VPS9 PF02204.16 MSTRG.9987.1_3 - 2e-28 98.5 0.0 3.5e-28 97.7 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain zf-A20 PF01754.14 MSTRG.9987.1_3 - 9.6e-12 44.5 5.1 2.1e-11 43.4 5.1 1.6 1 0 0 1 1 1 1 A20-like zinc finger SH3_9 PF14604.4 MSTRG.9315.2_3 - 1.5e-16 59.8 1.7 1.9e-13 49.9 0.1 2.8 3 0 0 3 3 3 2 Variant SH3 domain SH3_1 PF00018.26 MSTRG.9315.2_3 - 1.7e-14 53.0 0.1 4.5e-14 51.6 0.1 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.9315.2_3 - 3.2e-14 52.2 0.2 3.5e-06 26.5 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain C1_1 PF00130.20 MSTRG.9315.2_3 - 2.1e-06 27.3 14.2 2.1e-06 27.3 14.2 2.6 3 0 0 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) STAC2_u1 PF16664.3 MSTRG.9315.2_3 - 0.0017 18.7 0.1 0.0045 17.3 0.1 1.7 1 0 0 1 1 1 1 Unstructured on SH3 and cysteine-rich domain-containing protein 2 C1_2 PF03107.14 MSTRG.9315.2_3 - 0.044 14.0 8.4 0.17 12.1 8.4 2.0 1 0 0 1 1 1 0 C1 domain PHD PF00628.27 MSTRG.9315.2_3 - 0.41 10.5 12.1 0.54 10.1 7.4 2.8 2 0 0 2 2 2 0 PHD-finger PHD_2 PF13831.4 MSTRG.9315.2_3 - 2.3 7.7 6.2 1.7 8.1 1.2 2.6 2 0 0 2 2 2 0 PHD-finger Pkinase PF00069.23 MSTRG.24672.1_1 - 1.1e-73 247.7 0.0 2e-73 246.9 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain CaMKII_AD PF08332.8 MSTRG.24672.1_1 - 5.7e-41 139.5 0.0 1e-40 138.7 0.0 1.4 1 0 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II association domain Pkinase_Tyr PF07714.15 MSTRG.24672.1_1 - 1.2e-32 113.1 0.0 3.2e-32 111.7 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase SnoaL_3 PF13474.4 MSTRG.24672.1_1 - 0.00026 21.1 0.0 0.00063 19.9 0.0 1.6 1 0 0 1 1 1 1 SnoaL-like domain APH PF01636.21 MSTRG.24672.1_1 - 0.00042 20.2 0.3 0.45 10.3 0.1 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family DUF4440 PF14534.4 MSTRG.24672.1_1 - 0.00054 20.2 0.0 0.0011 19.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) Kdo PF06293.12 MSTRG.24672.1_1 - 0.0024 17.1 0.1 0.0066 15.7 0.1 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 MSTRG.24672.1_1 - 0.019 14.5 0.0 1.8 8.0 0.0 2.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PAP2 PF01569.19 MSTRG.1356.2_3 - 0.00022 20.9 2.0 0.00039 20.1 1.3 1.7 1 1 0 1 1 1 1 PAP2 superfamily Troponin PF00992.18 MSTRG.15332.3_2 - 4.9e-46 156.2 7.1 6.6e-46 155.8 7.1 1.2 1 0 0 1 1 1 1 Troponin PhaP_Bmeg PF09602.8 MSTRG.15332.3_2 - 0.038 13.8 0.2 0.087 12.6 0.1 1.4 1 1 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) PRK PF00485.16 MSTRG.6583.2_2 - 1.4e-61 207.5 0.0 2e-61 207.1 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family CPT PF07931.10 MSTRG.6583.2_2 - 1.9e-06 27.7 0.0 3.2e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.4 MSTRG.6583.2_2 - 2.1e-05 24.9 0.0 3.4e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.4 MSTRG.6583.2_2 - 0.00024 21.1 0.0 0.00038 20.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.4 MSTRG.6583.2_2 - 0.015 15.6 0.1 3.2 8.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.16 MSTRG.6583.2_2 - 0.02 14.5 0.0 0.44 10.1 0.0 2.1 2 0 0 2 2 2 0 Cytidylate kinase CoaE PF01121.18 MSTRG.6583.2_2 - 0.037 13.6 0.5 0.22 11.0 0.1 2.0 2 0 0 2 2 2 0 Dephospho-CoA kinase UPRTase PF14681.4 MSTRG.6583.2_3 - 1.2e-73 246.9 0.1 1.6e-73 246.5 0.1 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase tRNA-synt_2 PF00152.18 MSTRG.17821.1_1 - 2e-97 326.0 0.0 2.5e-97 325.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.23 MSTRG.17821.1_1 - 2.4e-08 33.7 0.0 4.3e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.18 MSTRG.17821.1_1 - 0.0015 18.0 1.4 0.92 8.8 0.4 2.6 2 1 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.23 MSTRG.17821.1_1 - 0.0068 16.3 0.1 0.024 14.5 0.1 1.8 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Lipase_GDSL_2 PF13472.4 MSTRG.26274.1_3 - 6.8e-07 29.7 0.1 2.6e-06 27.8 0.0 2.1 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family CSD PF00313.20 MSTRG.26274.1_3 - 0.00023 20.8 5.6 0.014 15.1 0.0 4.9 5 0 0 5 5 5 1 'Cold-shock' DNA-binding domain Lipase_GDSL PF00657.20 MSTRG.26274.1_3 - 0.062 13.1 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase Aminotran_5 PF00266.17 MSTRG.23924.1_3 - 1.6e-49 168.7 0.0 2.2e-49 168.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V VWA PF00092.26 MSTRG.1336.2_2 - 1.7e-77 259.5 0.0 4.4e-39 134.4 0.0 2.1 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.4 MSTRG.1336.2_2 - 1.7e-26 92.8 0.0 6.8e-13 49.1 0.0 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain LCCL PF03815.17 MSTRG.1336.2_2 - 1e-19 70.3 0.0 1.7e-19 69.6 0.0 1.4 1 0 0 1 1 1 1 LCCL domain VWA_CoxE PF05762.12 MSTRG.1336.2_2 - 2.1e-06 27.2 0.1 0.014 14.7 0.0 2.4 2 0 0 2 2 2 2 VWA domain containing CoxE-like protein VWA_3 PF13768.4 MSTRG.1336.2_2 - 0.00024 20.9 0.0 0.22 11.2 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain Rxt3 PF08642.8 MSTRG.1336.2_2 - 0.014 16.0 0.1 0.099 13.3 0.1 2.4 1 1 0 1 1 1 0 Histone deacetylation protein Rxt3 Aa_trans PF01490.16 MSTRG.838.1_3 - 4e-59 200.2 38.2 5.4e-59 199.8 38.2 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Connexin PF00029.17 MSTRG.12378.2_1 - 1e-80 270.6 5.6 1.8e-80 269.8 5.6 1.4 1 0 0 1 1 1 1 Connexin PEPCK PF00821.16 MSTRG.26618.1_1 - 1.5e-271 901.7 0.0 1.7e-271 901.5 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase Bim_N PF06773.9 MSTRG.26618.1_3 - 9.3 5.9 13.8 4.2 7.0 0.2 4.0 2 1 1 3 3 3 0 Bim protein N-terminus NIF PF03031.16 MSTRG.8188.1_2 - 4.9e-53 179.0 0.1 7e-53 178.4 0.1 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase SIR2 PF02146.15 MSTRG.14745.9_2 - 1.1e-45 155.6 0.0 1.6e-45 155.0 0.0 1.3 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.20 MSTRG.14745.9_2 - 0.068 12.8 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain EGF PF00008.25 MSTRG.7836.1_2 - 3.1e-59 196.7 246.8 4.5e-08 33.1 10.2 16.7 17 1 0 17 17 17 12 EGF-like domain hEGF PF12661.5 MSTRG.7836.1_2 - 3.8e-45 151.0 206.9 4.1e-07 30.3 7.9 17.7 16 0 0 16 16 16 12 Human growth factor-like EGF MNNL PF07657.11 MSTRG.7836.1_2 - 7e-24 83.5 2.5 7e-24 83.5 2.5 5.6 6 1 0 6 6 6 1 N terminus of Notch ligand DSL PF01414.17 MSTRG.7836.1_2 - 1.4e-23 82.7 6.5 1.4e-23 82.7 6.5 11.3 8 3 4 12 12 12 1 Delta serrate ligand EGF_2 PF07974.11 MSTRG.7836.1_2 - 4.9e-12 45.9 278.7 0.0013 18.9 9.8 18.7 18 0 0 18 18 18 11 EGF-like domain EGF_CA PF07645.13 MSTRG.7836.1_2 - 2.4 8.3 215.1 0.028 14.5 8.6 17.3 6 3 11 17 17 17 0 Calcium-binding EGF domain NAGLU_C PF12972.5 MSTRG.21084.3_1 - 4.3e-83 278.8 0.3 5.3e-83 278.4 0.3 1.1 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain NAGLU PF05089.10 MSTRG.21084.3_1 - 1.5e-54 185.1 0.0 2.5e-54 184.4 0.0 1.3 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU PF05089.10 MSTRG.21084.3_2 - 1.1e-73 247.9 0.3 1.6e-73 247.5 0.3 1.1 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain PDZ PF00595.22 MSTRG.557.1_2 - 7.1e-18 64.6 0.7 2.8e-11 43.5 0.1 2.3 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.557.1_2 - 4.9e-09 36.3 0.0 1.1e-05 25.6 0.0 2.3 1 1 1 2 2 2 2 PDZ domain Miff PF05644.9 MSTRG.12149.2_1 - 3.1e-54 184.5 1.7 4e-54 184.1 1.7 1.1 1 0 0 1 1 1 1 Mitochondrial and peroxisomal fission factor Mff Miff PF05644.9 MSTRG.12149.2_2 - 4e-46 157.9 2.6 1.3e-45 156.1 2.6 1.7 1 1 0 1 1 1 1 Mitochondrial and peroxisomal fission factor Mff DivIC PF04977.13 MSTRG.12149.2_2 - 0.13 11.9 0.4 0.24 11.1 0.4 1.3 1 0 0 1 1 1 0 Septum formation initiator FKBP_C PF00254.26 MSTRG.19794.3_2 - 3.3e-32 110.6 0.0 9.2e-30 102.7 0.0 2.1 2 0 0 2 2 2 2 FKBP-type peptidyl-prolyl cis-trans isomerase DUF1899 PF08953.9 MSTRG.24135.1_2 - 1.8e-11 43.6 0.4 3.5e-11 42.7 0.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40 PF00400.30 MSTRG.24135.1_2 - 1.1e-10 41.7 0.2 0.00027 21.5 0.3 3.1 2 1 1 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.24135.1_2 - 0.00021 21.4 0.0 0.018 15.2 0.0 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 MSTRG.24135.1_2 - 0.17 10.7 0.0 3.9 6.2 0.0 2.1 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein BTB PF00651.29 MSTRG.18897.1_3 - 1.2e-13 51.1 0.0 2.6e-13 50.0 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Slx4 PF09494.8 MSTRG.18897.1_3 - 6.1e-13 48.4 0.0 1.6e-12 47.0 0.0 1.8 1 0 0 1 1 1 1 Slx4 endonuclease zf-C2H2_jaz PF12171.6 MSTRG.18897.1_3 - 0.052 13.7 1.4 0.76 10.0 0.1 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding FYVE PF01363.19 MSTRG.18897.1_3 - 0.99 9.5 3.0 2.1 8.4 0.0 2.7 3 0 0 3 3 3 0 FYVE zinc finger HSP70 PF00012.18 MSTRG.17158.1_3 - 1.6e-197 657.3 9.0 1.8e-197 657.1 9.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 MSTRG.17158.1_3 - 3.9e-16 58.7 0.0 5.9e-16 58.0 0.0 1.2 1 0 0 1 1 1 1 MreB/Mbl protein FGGY_C PF02782.14 MSTRG.17158.1_3 - 0.00058 19.5 0.0 0.0017 18.0 0.0 1.8 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain CRIC_ras_sig PF10534.7 MSTRG.17158.1_3 - 0.02 14.9 0.0 0.02 14.9 0.0 2.0 3 0 0 3 3 3 0 Connector enhancer of kinase suppressor of ras DDR PF08841.8 MSTRG.17158.1_3 - 0.025 13.4 0.2 0.23 10.3 0.2 2.1 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain DUF1464 PF07318.10 MSTRG.17158.1_3 - 0.046 12.7 0.0 0.079 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1464) Peptidase_M10 PF00413.22 MSTRG.22728.1_3 - 1.5e-62 210.0 0.0 2.1e-62 209.5 0.0 1.2 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 MSTRG.22728.1_3 - 3.1e-26 90.9 12.1 7.3e-07 28.9 0.1 5.6 5 0 0 5 5 5 5 Hemopexin PG_binding_1 PF01471.16 MSTRG.22728.1_3 - 2e-08 34.2 0.1 4.9e-08 32.9 0.1 1.7 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Reprolysin_3 PF13582.4 MSTRG.22728.1_3 - 0.013 15.9 0.0 0.025 15.0 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.22 MSTRG.22728.1_3 - 0.033 13.7 0.2 4.8 6.6 0.1 2.4 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Reprolysin_5 PF13688.4 MSTRG.22728.1_3 - 0.045 13.8 0.0 0.079 13.0 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 DUF4953 PF16313.3 MSTRG.22728.1_3 - 0.056 12.5 0.0 0.091 11.8 0.0 1.2 1 0 0 1 1 1 0 Met-zincin Reprolysin_4 PF13583.4 MSTRG.22728.1_3 - 0.068 12.7 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Neisseria_TspB PF05616.11 MSTRG.22728.1_3 - 1.4 7.1 4.7 2.1 6.6 4.7 1.1 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein Sel1 PF08238.10 MSTRG.27972.2_3 - 0.0034 17.9 0.1 0.0077 16.8 0.1 1.6 1 0 0 1 1 1 1 Sel1 repeat Glyco_transf_17 PF04724.11 MSTRG.27403.1_3 - 5e-27 94.7 1.7 7.2e-23 81.0 0.0 3.3 3 1 1 4 4 4 2 Glycosyltransferase family 17 EGF_2 PF07974.11 MSTRG.27403.1_3 - 0.01 16.1 0.6 0.022 15.0 0.6 1.6 1 0 0 1 1 1 0 EGF-like domain PHD PF00628.27 MSTRG.3814.1_1 - 1.2 9.0 20.5 0.034 13.9 11.4 2.7 2 1 0 2 2 2 0 PHD-finger DUF4113 PF13438.4 MSTRG.9858.2_3 - 0.16 12.0 1.5 0.4 10.7 1.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4113) Reprolysin PF01421.17 MSTRG.20858.1_3 - 1.9e-64 217.2 0.0 1.9e-64 217.2 0.0 1.9 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 MSTRG.20858.1_3 - 1.6e-28 99.3 9.2 1.6e-28 99.3 9.2 3.6 3 2 0 3 3 3 1 ADAM cysteine-rich Reprolysin_5 PF13688.4 MSTRG.20858.1_3 - 1.2e-22 80.9 0.7 3.2e-22 79.5 0.7 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12 Pep_M12B_propep PF01562.17 MSTRG.20858.1_3 - 4.4e-19 69.0 0.0 1.1e-18 67.6 0.0 1.6 1 0 0 1 1 1 1 Reprolysin family propeptide Disintegrin PF00200.21 MSTRG.20858.1_3 - 5.7e-19 68.6 30.9 5.7e-19 68.6 30.9 4.8 5 1 0 5 5 5 1 Disintegrin Reprolysin_3 PF13582.4 MSTRG.20858.1_3 - 9.7e-15 55.0 0.3 1.8e-14 54.2 0.3 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 MSTRG.20858.1_3 - 1.4e-11 44.5 0.3 2.6e-11 43.7 0.3 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 MSTRG.20858.1_3 - 2e-09 37.3 0.2 3.2e-09 36.6 0.2 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.7 MSTRG.20858.1_3 - 0.048 12.5 0.5 0.084 11.7 0.5 1.3 1 0 0 1 1 1 0 Peptidase M66 BLM_N PF16202.3 MSTRG.2399.1_2 - 1.1e-25 90.5 33.9 1.1e-25 90.5 33.9 3.1 2 1 0 2 2 2 1 N-terminal region of Bloom syndrome protein BDHCT PF08072.9 MSTRG.2399.1_2 - 2.8e-19 68.7 1.5 5.3e-19 67.9 1.5 1.5 1 0 0 1 1 1 1 BDHCT (NUC031) domain DEAD PF00270.27 MSTRG.2399.1_2 - 1.6e-16 60.4 0.0 8.6e-16 58.1 0.0 2.1 3 0 0 3 3 3 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.3 MSTRG.2399.1_2 - 7.6e-16 58.4 3.8 7.6e-16 58.4 3.8 2.2 2 0 0 2 2 2 1 RecQ zinc-binding HRDC PF00570.21 MSTRG.2399.1_2 - 3.2e-14 52.5 0.0 7.4e-14 51.3 0.0 1.7 1 0 0 1 1 1 1 HRDC domain Helicase_C PF00271.29 MSTRG.2399.1_2 - 4.3e-14 52.7 0.0 1.7e-13 50.8 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RQC PF09382.8 MSTRG.2399.1_2 - 4.7e-10 39.1 0.0 1.2e-09 37.8 0.0 1.7 1 0 0 1 1 1 1 RQC domain ResIII PF04851.13 MSTRG.2399.1_2 - 0.0033 17.3 0.0 0.0081 16.0 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF1480 PF07351.11 MSTRG.2399.1_2 - 0.051 13.7 1.1 0.49 10.5 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1480) DUF1178 PF06676.9 MSTRG.2399.1_2 - 0.08 13.2 0.1 0.86 9.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1178) Glypican PF01153.17 MSTRG.15949.1_3 - 2.4e-226 752.8 0.6 3.2e-226 752.4 0.6 1.0 1 0 0 1 1 1 1 Glypican Fz PF01392.20 MSTRG.15949.1_3 - 0.022 15.4 0.3 0.022 15.4 0.3 1.9 2 0 0 2 2 2 0 Fz domain Methyltransf_16 PF10294.7 MSTRG.4683.1_1 - 2e-43 148.0 0.0 2.6e-43 147.6 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.12 MSTRG.4683.1_1 - 0.053 12.9 0.1 0.088 12.2 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_23 PF13489.4 MSTRG.4683.1_1 - 0.14 11.9 0.1 0.29 10.9 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain LIM PF00412.20 MSTRG.5146.1_3 - 3.3e-15 55.9 6.2 4.6e-15 55.4 6.2 1.2 1 0 0 1 1 1 1 LIM domain C1_4 PF07975.10 MSTRG.5146.1_3 - 0.058 13.5 6.8 0.095 12.8 6.8 1.4 1 0 0 1 1 1 0 TFIIH C1-like domain CAP_N PF01213.17 MSTRG.103.1_1 - 5.6e-105 351.2 0.0 8.1e-105 350.7 0.0 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.9 MSTRG.103.1_1 - 1.8e-63 212.7 0.6 2.4e-63 212.3 0.6 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal VPS28 PF03997.10 MSTRG.103.1_2 - 1.9e-64 216.7 0.2 2.5e-64 216.3 0.2 1.1 1 0 0 1 1 1 1 VPS28 protein zf-H2C2_2 PF13465.4 MSTRG.4990.1_3 - 2.3e-39 132.0 41.4 5.9e-09 35.8 1.2 6.7 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.4990.1_3 - 4.8e-22 77.0 53.7 3e-05 24.1 1.1 7.2 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.4990.1_3 - 4.5e-21 73.6 43.1 0.00032 21.2 1.9 6.9 6 0 0 6 6 6 6 C2H2-type zinc finger zf-met PF12874.5 MSTRG.4990.1_3 - 3.4e-14 52.5 39.1 0.0023 18.1 1.4 6.4 6 0 0 6 6 6 5 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 MSTRG.4990.1_3 - 2.4e-06 27.2 44.9 0.0055 16.5 0.3 7.0 7 0 0 7 7 7 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.4990.1_3 - 9.1e-06 25.7 26.5 0.44 10.8 0.3 6.2 6 0 0 6 6 6 4 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 MSTRG.4990.1_3 - 1.3e-05 25.2 27.9 0.015 15.4 3.7 4.2 3 1 0 3 3 3 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.5 MSTRG.4990.1_3 - 0.00025 21.2 33.7 0.58 10.4 0.4 6.3 1 1 3 5 5 5 2 C2H2 type zinc-finger (2 copies) LIM PF00412.20 MSTRG.4990.1_3 - 0.083 13.0 21.4 1 9.5 1.3 4.8 1 1 2 4 4 4 0 LIM domain zf-Sec23_Sec24 PF04810.13 MSTRG.4990.1_3 - 0.088 12.7 13.9 2.8 7.9 0.4 5.4 3 2 3 6 6 6 0 Sec23/Sec24 zinc finger zinc_ribbon_15 PF17032.3 MSTRG.4990.1_3 - 0.09 13.4 17.1 3.9 8.1 0.7 3.6 1 1 2 3 3 3 0 zinc-ribbon family PRP21_like_P PF12230.6 MSTRG.4990.1_3 - 0.11 12.2 0.1 0.11 12.2 0.1 3.0 3 1 1 4 4 4 0 Pre-mRNA splicing factor PRP21 like protein C1_2 PF03107.14 MSTRG.4990.1_3 - 0.3 11.3 23.1 2.6 8.3 3.7 5.6 3 2 1 4 4 4 0 C1 domain Zf_RING PF16744.3 MSTRG.4990.1_3 - 0.78 9.8 19.2 16 5.6 0.2 6.0 2 1 4 6 6 5 0 KIAA1045 RING finger BolA PF01722.16 MSTRG.4990.1_3 - 1.3 9.2 6.4 72 3.6 0.1 3.7 1 1 1 2 2 2 0 BolA-like protein DUF2180 PF09947.7 MSTRG.4990.1_3 - 2.1 8.2 11.7 2.2 8.2 1.3 3.6 2 2 2 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2180) DUF2256 PF10013.7 MSTRG.4990.1_3 - 2.9 7.9 13.5 74 3.5 0.0 6.0 6 0 0 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2H2_9 PF16293.3 MSTRG.4990.1_3 - 3.9 7.3 8.4 30 4.4 0.1 4.6 5 0 0 5 5 5 0 C2H2 type zinc-finger (1 copy) Zn-ribbon_8 PF09723.8 MSTRG.4990.1_3 - 5.3 7.1 18.9 3.6 7.7 1.6 4.9 1 1 3 5 5 5 0 Zinc ribbon domain zf-BED PF02892.13 MSTRG.4990.1_3 - 8.6 6.4 44.1 2.5 8.1 2.2 6.5 1 1 5 6 6 6 0 BED zinc finger HEAT PF02985.20 MSTRG.1230.1_3 - 8.2e-09 34.8 7.4 0.044 13.9 0.0 5.4 5 0 0 5 5 5 3 HEAT repeat Cnd1 PF12717.5 MSTRG.1230.1_3 - 9.1e-09 35.4 2.5 4.7e-05 23.3 0.5 3.3 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.4 MSTRG.1230.1_3 - 1e-06 28.9 2.3 0.094 13.0 0.2 4.3 2 1 2 4 4 4 2 HEAT repeats Adaptin_N PF01602.18 MSTRG.1230.1_3 - 1.7e-06 26.8 5.4 3.2e-05 22.5 2.2 2.8 3 0 0 3 3 3 2 Adaptin N terminal region HEAT_EZ PF13513.4 MSTRG.1230.1_3 - 0.0021 18.4 4.6 0.47 10.9 0.0 4.3 5 1 0 5 5 5 1 HEAT-like repeat Cohesin_HEAT PF12765.5 MSTRG.1230.1_3 - 0.035 14.2 7.1 0.75 9.9 0.6 3.7 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion RasGEF_N_2 PF14663.4 MSTRG.1230.1_3 - 0.047 13.9 11.2 20 5.5 4.6 4.2 2 1 1 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Hormone_recep PF00104.28 MSTRG.15976.1_3 - 3.9e-11 42.8 3.5 5.6e-11 42.3 3.5 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor LRR19-TM PF15176.4 MSTRG.22236.1_1 - 6.1e-26 90.4 0.0 1e-25 89.6 0.0 1.3 1 0 0 1 1 1 1 Leucine-rich repeat family 19 TM domain Pkinase PF00069.23 MSTRG.28762.1_1 - 4.5e-08 32.7 0.0 6.4e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain UPF0004 PF00919.18 MSTRG.9157.1_1 - 4.8e-23 80.9 0.0 7.9e-23 80.2 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 TraT PF05818.10 MSTRG.9157.1_1 - 0.0083 15.7 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 Enterobacterial TraT complement resistance protein DUF4127 PF13552.4 MSTRG.9157.1_1 - 0.026 13.0 0.0 0.036 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4127) BMC PF00936.17 MSTRG.9157.1_1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 BMC domain G-patch PF01585.21 MSTRG.12577.1_3 - 2.6e-11 43.1 1.6 7.6e-11 41.6 1.6 1.8 1 0 0 1 1 1 1 G-patch domain Ribosomal_60s PF00428.17 MSTRG.17940.2_3 - 5.4 7.5 7.2 11 6.5 7.2 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein NHS PF15273.4 MSTRG.9666.3_3 - 8.2e-124 414.9 65.5 8.2e-124 414.9 65.5 3.5 2 2 0 2 2 2 1 NHS-like VGLL4 PF15245.4 MSTRG.24760.2_1 - 6.8e-95 317.1 5.4 1.1e-94 316.4 5.4 1.3 1 0 0 1 1 1 1 Transcription cofactor vestigial-like protein 4 Vg_Tdu PF07545.12 MSTRG.24760.2_1 - 0.0032 17.0 0.0 2.2 8.0 0.0 2.7 2 0 0 2 2 2 2 Vestigial/Tondu family Pkinase_Tyr PF07714.15 MSTRG.10566.2_1 - 3e-128 426.4 0.0 3.2e-73 246.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.10566.2_1 - 6.1e-68 228.9 0.0 1e-40 139.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain SH2 PF00017.22 MSTRG.10566.2_1 - 9.4e-05 22.3 0.0 0.00033 20.5 0.0 2.0 2 0 0 2 2 2 1 SH2 domain Kinase-like PF14531.4 MSTRG.10566.2_1 - 0.00049 19.4 0.1 0.17 11.0 0.0 2.8 2 1 0 2 2 2 2 Kinase-like Kdo PF06293.12 MSTRG.10566.2_1 - 0.0046 16.2 0.0 1.9 7.7 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 MSTRG.10566.2_1 - 0.084 12.3 0.3 0.83 9.1 0.0 2.1 2 0 0 2 2 2 0 RIO1 family BET PF17035.3 MSTRG.10566.2_1 - 0.095 12.8 0.0 0.58 10.3 0.0 2.2 2 0 0 2 2 2 0 Bromodomain extra-terminal - transcription regulation FHA PF00498.24 MSTRG.15102.1_2 - 7.7e-18 64.5 0.0 1.5e-17 63.5 0.0 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.3 MSTRG.15102.1_2 - 0.0003 20.9 0.0 0.0066 16.6 0.0 2.3 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain ABC_tran PF00005.25 MSTRG.15308.1_1 - 2.5e-11 44.1 0.0 3.8e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.4 MSTRG.15308.1_1 - 0.052 13.1 0.0 0.098 12.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_membrane PF00664.21 MSTRG.15308.1_3 - 1.6e-05 24.5 0.0 2.5e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 7tm_1 PF00001.19 MSTRG.11095.1_2 - 2.7e-54 184.1 21.9 3.8e-54 183.6 21.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 MSTRG.11095.1_2 - 5.9e-12 45.4 17.2 1e-11 44.6 17.2 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 MSTRG.11095.1_2 - 7.1e-05 22.1 10.7 7.1e-05 22.1 10.7 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx TAS2R PF05296.11 MSTRG.11095.1_2 - 0.00042 19.4 16.3 0.00068 18.7 16.3 1.3 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7TM_GPCR_Srw PF10324.7 MSTRG.11095.1_2 - 0.001 18.3 12.7 0.0018 17.5 12.7 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw FA_desaturase PF00487.22 MSTRG.11095.1_2 - 0.29 10.8 6.0 1.7 8.3 0.1 2.3 2 0 0 2 2 2 0 Fatty acid desaturase Kringle PF00051.16 MSTRG.15312.1_1 - 1.6e-78 258.9 36.8 7e-29 99.8 11.5 3.5 3 0 0 3 3 3 3 Kringle domain Trypsin PF00089.24 MSTRG.15312.1_1 - 1.3e-37 129.6 0.8 2.2e-37 128.9 0.8 1.4 1 0 0 1 1 1 1 Trypsin DUF316 PF03761.13 MSTRG.15312.1_1 - 0.0057 16.1 0.0 0.0089 15.5 0.0 1.2 1 0 0 1 1 1 1 Chymotrypsin family Peptidase-S1 DUF1986 PF09342.9 MSTRG.15312.1_1 - 0.014 15.7 0.0 0.023 14.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) DBD_Tnp_Hermes PF10683.7 MSTRG.25440.1_3 - 2.2e-05 23.9 0.1 4e-05 23.1 0.1 1.4 1 0 0 1 1 1 1 Hermes transposase DNA-binding domain zf-BED PF02892.13 MSTRG.25440.1_3 - 0.0021 18.0 0.1 0.0021 18.0 0.1 2.2 2 0 0 2 2 2 1 BED zinc finger O-FucT PF10250.7 MSTRG.22880.1_2 - 8e-46 157.0 0.0 9.6e-46 156.8 0.0 1.1 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Bclx_interact PF08945.8 MSTRG.22880.1_2 - 0.026 14.1 0.0 0.064 12.9 0.0 1.6 1 0 0 1 1 1 0 Bcl-x interacting, BH3 domain ADIP PF11559.6 MSTRG.13562.2_3 - 1.2e-32 113.0 12.3 1.5e-32 112.7 12.3 1.1 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding Cytochrom_B562 PF07361.9 MSTRG.13562.2_3 - 0.018 15.6 5.6 0.11 13.0 5.7 1.9 1 1 0 1 1 1 0 Cytochrome b562 PTRF_SDPR PF15237.4 MSTRG.13562.2_3 - 0.035 13.6 10.6 0.053 13.0 10.6 1.4 1 0 0 1 1 1 0 PTRF/SDPR family Rab15_effector PF15208.4 MSTRG.13562.2_3 - 0.039 13.1 4.1 1.3 8.1 0.0 2.1 1 1 1 2 2 2 0 Rab15 effector AAA_23 PF13476.4 MSTRG.13562.2_3 - 0.046 14.1 9.1 0.064 13.6 9.1 1.1 1 0 0 1 1 1 0 AAA domain Spc7 PF08317.9 MSTRG.13562.2_3 - 0.081 11.6 15.8 0.11 11.2 15.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Atg14 PF10186.7 MSTRG.13562.2_3 - 0.18 10.7 12.0 0.26 10.2 12.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 IncA PF04156.12 MSTRG.13562.2_3 - 0.21 11.2 15.7 0.32 10.6 15.7 1.3 1 0 0 1 1 1 0 IncA protein Mnd1 PF03962.13 MSTRG.13562.2_3 - 0.34 10.6 13.7 0.51 10.1 13.7 1.2 1 0 0 1 1 1 0 Mnd1 family Exonuc_VII_L PF02601.13 MSTRG.13562.2_3 - 0.46 9.9 7.4 0.57 9.6 7.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit OmpH PF03938.12 MSTRG.13562.2_3 - 0.75 9.7 16.7 0.99 9.3 8.1 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) EMP24_GP25L PF01105.22 MSTRG.13562.2_3 - 0.9 9.3 10.1 0.14 12.0 3.1 2.1 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD Fib_alpha PF08702.8 MSTRG.13562.2_3 - 1.8 8.6 10.2 3 7.9 10.2 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF3450 PF11932.6 MSTRG.13562.2_3 - 3.7 6.7 13.8 0.49 9.5 8.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF972 PF06156.11 MSTRG.13562.2_3 - 5.6 7.5 12.4 31 5.1 12.4 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF972) DUF848 PF05852.9 MSTRG.13562.2_3 - 6.5 6.7 11.1 3 7.8 7.6 2.0 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) AAA PF00004.27 MSTRG.20252.1_1 - 0.00035 20.9 0.0 0.00073 19.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 MSTRG.20252.1_1 - 0.00051 20.2 0.0 0.002 18.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 MSTRG.20252.1_1 - 0.0013 19.0 0.2 0.0055 17.0 0.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.19 MSTRG.20252.1_1 - 0.0017 17.6 0.0 0.0036 16.6 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI PhoH PF02562.14 MSTRG.20252.1_1 - 0.0019 17.6 0.0 0.0032 16.8 0.0 1.2 1 0 0 1 1 1 1 PhoH-like protein AAA_18 PF13238.4 MSTRG.20252.1_1 - 0.0028 18.0 0.0 0.013 15.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.20 MSTRG.20252.1_1 - 0.0041 17.4 0.0 0.01 16.1 0.0 1.7 1 0 0 1 1 1 1 RNA helicase IstB_IS21 PF01695.15 MSTRG.20252.1_1 - 0.0048 16.6 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.4 MSTRG.20252.1_1 - 0.012 15.6 0.0 0.023 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.12 MSTRG.20252.1_1 - 0.014 15.3 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.10 MSTRG.20252.1_1 - 0.033 14.0 0.0 0.078 12.8 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_28 PF13521.4 MSTRG.20252.1_1 - 0.076 13.1 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF4201 PF13870.4 MSTRG.20252.1_1 - 0.088 12.3 1.3 0.15 11.6 1.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) AAA_33 PF13671.4 MSTRG.20252.1_1 - 0.091 12.8 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain ResIII PF04851.13 MSTRG.20252.1_1 - 0.14 12.1 0.0 0.42 10.5 0.0 1.6 1 1 0 2 2 2 0 Type III restriction enzyme, res subunit FYVE PF01363.19 MSTRG.7537.3_1 - 1.3e-18 66.8 11.8 1.3e-18 66.8 11.8 3.4 3 0 0 3 3 3 1 FYVE zinc finger ATG16 PF08614.9 MSTRG.7537.3_1 - 2.2 8.3 6.9 7.2 6.6 6.9 1.8 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) PH PF00169.27 MSTRG.8203.3_1 - 3.3e-14 53.1 0.2 6.4e-14 52.2 0.2 1.5 1 0 0 1 1 1 1 PH domain BTK PF00779.17 MSTRG.8203.3_1 - 1.8e-11 43.5 4.2 1.8e-11 43.5 4.2 3.2 3 0 0 3 3 3 1 BTK motif 7tm_1 PF00001.19 MSTRG.8203.3_2 - 4.9e-37 127.5 24.3 8.1e-37 126.8 24.3 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ribosomal_S10 PF00338.20 MSTRG.8203.3_2 - 3e-14 52.9 0.1 5.2e-14 52.1 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Pkinase_Tyr PF07714.15 MSTRG.8203.3_3 - 2.8e-88 295.4 0.0 3.9e-88 295.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.8203.3_3 - 1.6e-45 155.4 0.0 2.3e-45 154.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 MSTRG.8203.3_3 - 6.7e-20 70.8 0.3 1.4e-19 69.8 0.3 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 MSTRG.8203.3_3 - 2.5e-12 46.1 0.0 7e-12 44.6 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.8203.3_3 - 5.1e-06 26.1 0.5 1.7e-05 24.4 0.2 2.2 3 0 0 3 3 3 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.8203.3_3 - 0.00019 20.9 0.1 0.00063 19.2 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_3 PF08239.9 MSTRG.8203.3_3 - 0.00039 20.5 0.3 0.00087 19.4 0.3 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_4 PF06347.11 MSTRG.8203.3_3 - 0.018 14.7 0.1 0.043 13.5 0.1 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain PK PF00224.19 MSTRG.5466.1_3 - 8e-165 547.7 0.9 1e-164 547.4 0.9 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.14 MSTRG.5466.1_3 - 6.9e-33 113.2 0.0 1.4e-32 112.2 0.0 1.6 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.12 MSTRG.5466.1_3 - 0.0063 15.5 0.1 0.012 14.6 0.1 1.4 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family RRM_1 PF00076.20 MSTRG.4179.4_2 - 7.6e-18 64.0 0.0 1.6e-17 62.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPR_2 PF07719.15 MSTRG.4179.4_2 - 3.1e-10 39.2 1.4 0.031 14.2 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.4179.4_2 - 5.4e-06 25.9 2.6 0.033 13.9 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.4179.4_2 - 6.7e-06 26.4 0.1 0.0072 16.7 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat RRM_occluded PF16842.3 MSTRG.4179.4_2 - 2.6e-05 23.9 0.0 4.8e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_5 PF13893.4 MSTRG.4179.4_2 - 7.8e-05 22.1 0.0 0.00017 21.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_3 PF15663.3 MSTRG.4179.4_2 - 0.0033 17.5 0.7 0.0092 16.1 0.7 1.7 1 0 0 1 1 1 1 Zinc-finger containing family TPR_16 PF13432.4 MSTRG.4179.4_2 - 0.0045 17.5 0.1 1.2 9.7 0.0 2.8 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.4179.4_2 - 0.005 17.0 0.1 0.019 15.2 0.2 2.0 1 1 1 2 2 2 1 Tetratricopeptide repeat zf-CCCH PF00642.22 MSTRG.4179.4_2 - 0.017 14.9 4.5 0.043 13.6 4.5 1.7 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) TPR_12 PF13424.4 MSTRG.4179.4_2 - 0.025 14.7 0.3 14 5.9 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.4179.4_2 - 0.031 15.0 0.6 5.3 8.0 0.0 3.6 3 1 1 4 4 3 0 Tetratricopeptide repeat RRM_3 PF08777.9 MSTRG.4179.4_2 - 0.035 14.0 0.0 0.035 14.0 0.0 2.5 2 0 0 2 2 2 0 RNA binding motif TPR_8 PF13181.4 MSTRG.4179.4_2 - 0.045 13.8 5.3 2.4 8.5 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.4179.4_2 - 0.096 12.3 0.5 0.4 10.3 0.0 2.3 2 1 0 2 2 2 0 TPR repeat PNISR PF15996.3 MSTRG.4179.4_2 - 1.6 8.7 24.3 2.8 7.9 24.3 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Hamartin PF04388.10 MSTRG.4179.4_2 - 1.8 7.0 13.4 2.5 6.5 13.4 1.1 1 0 0 1 1 1 0 Hamartin protein zf-CCCH_2 PF14608.4 MSTRG.4179.4_2 - 2.5 8.6 5.3 12 6.4 5.4 2.3 1 1 0 1 1 1 0 RNA-binding, Nab2-type zinc finger ATP-synt_ab PF00006.23 MSTRG.6518.1_1 - 7.3e-64 215.2 0.0 1.1e-63 214.7 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.21 MSTRG.6518.1_1 - 3.1e-23 81.9 2.4 5.9e-23 81.0 2.4 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATPase_2 PF01637.16 MSTRG.6518.1_1 - 0.019 14.7 0.0 0.032 14.0 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DUF258 PF03193.14 MSTRG.6518.1_1 - 0.05 13.4 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ATPase PF06745.11 MSTRG.6518.1_1 - 0.072 12.3 0.1 0.12 11.6 0.1 1.3 1 0 0 1 1 1 0 KaiC NB-ARC PF00931.20 MSTRG.6518.1_1 - 0.1 11.5 0.1 0.2 10.5 0.1 1.4 1 0 0 1 1 1 0 NB-ARC domain GoLoco PF02188.15 MSTRG.10299.4_2 - 2.3e-06 26.8 1.9 5.7e-06 25.6 1.9 1.7 1 0 0 1 1 1 1 GoLoco motif RGS PF00615.17 MSTRG.10299.4_3 - 2.6e-31 108.2 1.0 4.7e-31 107.4 1.0 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain RBD PF02196.13 MSTRG.10299.4_3 - 3.9e-28 97.2 0.0 1e-19 70.3 0.0 2.5 2 0 0 2 2 2 2 Raf-like Ras-binding domain TUG-UBL1 PF11470.6 MSTRG.10299.4_3 - 0.0037 17.4 0.2 0.24 11.6 0.1 2.8 3 0 0 3 3 3 1 TUG ubiquitin-like domain Collagen PF01391.16 MSTRG.10324.2_2 - 5.5e-52 173.2 194.8 8.8e-10 38.1 25.0 9.2 4 3 3 7 7 7 7 Collagen triple helix repeat (20 copies) MFS_1 PF07690.14 MSTRG.26726.1_1 - 1.5e-31 109.5 42.8 1.5e-18 66.7 25.4 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily FKBP_C PF00254.26 MSTRG.14067.1_3 - 9.4e-24 83.4 0.0 1.3e-23 82.9 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Kelch_1 PF01344.23 MSTRG.21296.1_2 - 6.9e-36 121.4 6.8 3.7e-11 42.3 0.2 3.6 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.4 MSTRG.21296.1_2 - 1.6e-22 78.8 0.6 1.6e-08 34.4 0.0 3.1 1 1 2 3 3 3 3 Kelch motif Kelch_4 PF13418.4 MSTRG.21296.1_2 - 3.8e-15 55.4 0.7 0.00033 20.4 0.0 3.1 2 1 1 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.13 MSTRG.21296.1_2 - 6.2e-13 48.0 1.9 0.00087 19.0 0.0 3.5 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.4 MSTRG.21296.1_2 - 1e-12 47.9 2.8 0.00073 19.6 0.1 3.1 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_5 PF13854.4 MSTRG.21296.1_2 - 1.9e-06 27.5 4.6 0.0026 17.6 0.0 3.2 2 1 1 3 3 3 2 Kelch motif CALCOCO1 PF07888.9 MSTRG.17241.3_3 - 6.1e-78 262.8 68.7 6.2e-77 259.4 33.6 3.3 2 1 1 3 3 3 2 Calcium binding and coiled-coil domain (CALCOCO1) like C1_4 PF07975.10 MSTRG.17241.3_3 - 0.035 14.3 1.9 0.1 12.8 1.9 1.8 1 0 0 1 1 1 0 TFIIH C1-like domain UBZ_FAAP20 PF15750.3 MSTRG.17241.3_3 - 0.21 11.5 3.8 3 7.7 0.6 2.8 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger zf-C2H2_4 PF13894.4 MSTRG.17241.3_3 - 1.1 10.1 9.5 1.5 9.7 0.7 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger PID PF00640.21 MSTRG.18705.1_1 - 4.7e-09 36.3 0.1 1.6e-08 34.5 0.1 2.0 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) ATP-synt_Eps PF04627.11 MSTRG.9321.1_1 - 6.8e-18 64.3 1.4 6.8e-18 64.3 1.4 1.7 2 0 0 2 2 2 1 Mitochondrial ATP synthase epsilon chain Tcf25 PF04910.12 MSTRG.23147.1_2 - 2.6e-118 394.8 3.2 3.3e-118 394.5 3.2 1.1 1 0 0 1 1 1 1 Transcriptional repressor TCF25 TPR_14 PF13428.4 MSTRG.23147.1_2 - 0.36 11.7 3.1 58 4.8 0.0 4.1 4 1 1 5 5 5 0 Tetratricopeptide repeat RRM_1 PF00076.20 MSTRG.17331.2_1 - 2.3e-11 43.2 0.0 4.9e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 MSTRG.17331.2_1 - 5.9e-06 25.8 0.0 1.3e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP PF02037.25 MSTRG.17331.2_2 - 9.7e-11 41.0 1.4 1.8e-10 40.2 1.4 1.5 1 0 0 1 1 1 1 SAP domain Patched PF02460.16 MSTRG.23375.2_3 - 2.4e-22 78.7 24.4 1.9e-15 55.9 5.8 2.2 2 0 0 2 2 2 2 Patched family MMPL PF03176.13 MSTRG.23375.2_3 - 5e-13 48.6 33.3 3.6e-09 35.9 11.0 2.2 2 0 0 2 2 2 2 MMPL family Sterol-sensing PF12349.6 MSTRG.23375.2_3 - 3.4e-12 46.3 10.8 3.4e-12 46.3 10.8 2.5 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Anillin PF08174.9 MSTRG.22439.1_1 - 2.8e-50 170.3 0.1 7.7e-50 168.9 0.0 1.8 2 0 0 2 2 2 1 Cell division protein anillin PH PF00169.27 MSTRG.22439.1_1 - 8.6e-08 32.5 0.0 1.8e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 PH domain HR1 PF02185.14 MSTRG.22439.1_1 - 6e-05 22.9 2.5 0.00015 21.7 2.5 1.6 1 0 0 1 1 1 1 Hr1 repeat PI3K_rbd PF00794.16 MSTRG.20607.1_3 - 2.3e-08 34.0 0.0 3e-08 33.7 0.0 1.1 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain zf-RING_2 PF13639.4 MSTRG.7931.2_1 - 0.64 10.2 10.3 0.4 10.9 4.2 2.4 2 0 0 2 2 2 0 Ring finger domain fn3 PF00041.19 MSTRG.4605.2_1 - 1.4e-09 38.1 0.5 0.0093 16.2 0.0 3.6 3 0 0 3 3 3 2 Fibronectin type III domain fn3_2 PF16893.3 MSTRG.4605.2_1 - 0.015 15.3 0.0 0.045 13.8 0.0 1.8 2 0 0 2 2 2 0 Fibronectin type III domain Lep_receptor_Ig PF06328.9 MSTRG.4605.2_3 - 4.1e-08 33.0 0.0 9.1e-08 31.9 0.0 1.6 1 0 0 1 1 1 1 Ig-like C2-type domain Ig_2 PF13895.4 MSTRG.4605.2_3 - 0.015 15.5 0.3 0.055 13.7 0.0 2.1 2 0 0 2 2 2 0 Immunoglobulin domain Na_Ca_ex PF01699.22 MSTRG.22489.1_3 - 4.5e-27 94.8 7.9 5.8e-27 94.4 7.9 1.1 1 0 0 1 1 1 1 Sodium/calcium exchanger protein Gate PF07670.12 MSTRG.22489.1_3 - 0.22 11.7 2.9 0.34 11.1 1.1 2.2 1 1 1 2 2 2 0 Nucleoside recognition VKOR PF07884.12 MSTRG.22489.1_3 - 1.4 8.9 10.9 0.57 10.2 7.1 2.1 1 1 1 2 2 2 0 Vitamin K epoxide reductase family Lactamase_B_6 PF16661.3 MSTRG.5928.1_1 - 0.0081 15.5 0.1 0.031 13.6 0.0 1.9 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily domain Sulfatase PF00884.21 MSTRG.9248.3_3 - 4.6e-74 249.5 0.0 5.8e-74 249.1 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.4 MSTRG.9248.3_3 - 0.0023 18.5 0.0 0.0064 17.1 0.0 1.7 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.20 MSTRG.9248.3_3 - 0.014 14.9 0.0 0.091 12.2 0.0 2.0 1 1 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4149 PF13664.4 MSTRG.23817.1_2 - 3e-16 59.5 3.2 3e-16 59.5 3.2 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) zf-C2H2 PF00096.24 MSTRG.1001.1_3 - 5.5e-11 42.2 31.5 5e-05 23.4 4.9 4.5 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.1001.1_3 - 1.2e-09 38.0 10.3 2e-07 31.0 1.8 3.7 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.1001.1_3 - 5e-06 26.8 22.4 0.014 16.1 3.0 4.4 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.1001.1_3 - 0.01 15.7 1.0 0.01 15.7 1.0 3.1 3 1 0 3 3 3 0 C2H2-type zinc finger zf-met PF12874.5 MSTRG.1001.1_3 - 0.016 15.5 6.6 0.3 11.4 0.9 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type FOXP-CC PF16159.3 MSTRG.1001.1_3 - 1.1 9.8 3.9 12 6.5 1.0 2.4 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-H2C2_5 PF13909.4 MSTRG.1001.1_3 - 1.3 8.7 0.0 1.3 8.7 0.0 3.7 4 0 0 4 4 4 0 C2H2-type zinc-finger domain DOCK-C2 PF14429.4 MSTRG.18048.2_1 - 1.9e-15 57.1 0.0 4.6e-15 55.8 0.0 1.7 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins ATP-synt_G PF04718.13 MSTRG.18048.2_1 - 0.061 14.0 0.1 0.47 11.2 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial ATP synthase g subunit Pkinase PF00069.23 MSTRG.7545.1_1 - 4.4e-71 239.2 0.0 5.4e-71 238.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.7545.1_1 - 4.2e-46 157.2 0.0 5.8e-46 156.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.7545.1_1 - 0.0022 17.2 0.0 0.011 14.9 0.0 2.0 1 1 1 2 2 2 1 Kinase-like Glycos_trans_3N PF02885.15 MSTRG.7545.1_1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family, helical bundle domain WD40 PF00400.30 MSTRG.26119.2_2 - 2.3e-60 199.0 34.3 7.1e-09 36.0 0.3 9.1 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.26119.2_2 - 2.5e-23 82.0 6.0 0.00038 20.6 0.1 6.3 2 2 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.10 MSTRG.26119.2_2 - 8.7e-12 45.2 0.0 1.8e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain Ge1_WD40 PF16529.3 MSTRG.26119.2_2 - 1.6e-08 33.8 0.1 0.018 13.9 0.0 5.0 3 3 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.10 MSTRG.26119.2_2 - 3.8e-06 26.6 1.3 0.23 11.3 0.1 5.1 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Nup160 PF11715.6 MSTRG.26119.2_2 - 0.00013 20.6 4.6 0.92 7.9 0.1 4.7 3 2 2 5 5 5 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.3 MSTRG.26119.2_2 - 0.00054 18.9 6.4 0.25 10.1 0.3 4.1 3 1 1 4 4 4 2 Partner and localizer of BRCA2 WD40 domain Cytochrom_D1 PF02239.14 MSTRG.26119.2_2 - 0.0031 16.0 0.0 0.69 8.2 0.0 2.8 3 0 0 3 3 3 1 Cytochrome D1 heme domain Frtz PF11768.6 MSTRG.26119.2_2 - 0.0062 14.8 0.0 6.1 4.9 0.0 3.0 2 1 1 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz Nbas_N PF15492.4 MSTRG.26119.2_2 - 0.0087 15.3 2.0 3.7 6.6 0.1 4.3 3 2 2 5 5 5 1 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.3 MSTRG.26119.2_2 - 0.027 13.7 0.0 23 4.0 0.0 3.6 4 0 0 4 4 4 0 WD40-like domain Nucleoporin_N PF08801.9 MSTRG.26119.2_2 - 0.072 11.7 0.1 1.5 7.4 0.0 2.8 3 0 0 3 3 3 0 Nup133 N terminal like FAD_binding_9 PF08021.9 MSTRG.26119.2_2 - 0.13 12.4 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain DUF2418 PF10332.7 MSTRG.18961.1_1 - 0.053 13.9 0.1 0.13 12.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2418) Tuberin PF03542.14 MSTRG.18961.1_3 - 1.2e-145 485.0 2.0 2.1e-145 484.2 2.0 1.4 1 0 0 1 1 1 1 Tuberin DUF3384 PF11864.6 MSTRG.18961.1_3 - 3e-64 217.6 5.2 5.7e-64 216.7 3.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.13 MSTRG.18961.1_3 - 2.8e-43 147.5 0.0 5.2e-43 146.6 0.0 1.5 1 0 0 1 1 1 1 Rap/ran-GAP Pkinase PF00069.23 MSTRG.14030.2_2 - 1.5e-59 201.4 0.0 1.9e-59 201.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.14030.2_2 - 5.6e-24 84.7 0.0 7.4e-24 84.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 MSTRG.14030.2_2 - 1.3e-06 27.8 0.1 1.9e-06 27.3 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 MSTRG.14030.2_2 - 0.014 14.6 0.0 0.03 13.5 0.0 1.5 2 0 0 2 2 2 0 Kinase-like INCENP_ARK-bind PF03941.13 MSTRG.14030.2_2 - 0.13 12.0 0.1 0.25 11.2 0.1 1.3 1 0 0 1 1 1 0 Inner centromere protein, ARK binding region FGF PF00167.16 MSTRG.20854.1_1 - 1.3e-39 135.0 0.8 1.8e-39 134.5 0.8 1.2 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.11 MSTRG.20854.1_1 - 0.0042 17.2 0.3 0.017 15.2 0.1 2.0 2 0 0 2 2 2 1 Fascin domain CoA_transf_3 PF02515.15 MSTRG.22000.1_1 - 5.2e-128 427.1 0.0 6.2e-128 426.9 0.0 1.1 1 0 0 1 1 1 1 CoA-transferase family III CAMSAP_CH PF11971.6 MSTRG.16897.2_1 - 6.1e-33 112.4 0.2 1.1e-32 111.5 0.2 1.5 1 0 0 1 1 1 1 CAMSAP CH domain CH PF00307.29 MSTRG.16897.2_1 - 5e-05 23.3 0.0 9.1e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain DUF3584 PF12128.6 MSTRG.23911.1_1 - 0.15 9.5 18.7 0.21 8.9 18.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Golgin_A5 PF09787.7 MSTRG.23911.1_1 - 0.19 11.1 21.5 0.22 10.8 21.5 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF87 PF01935.15 MSTRG.23911.1_1 - 0.44 10.4 6.8 0.69 9.8 6.8 1.3 1 1 0 1 1 1 0 Domain of unknown function DUF87 TPR_MLP1_2 PF07926.10 MSTRG.23911.1_1 - 0.86 9.5 27.6 3.8 7.5 18.9 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein KAP_NTPase PF07693.12 MSTRG.23911.1_1 - 1.6 7.8 10.4 5.5 6.0 10.4 1.8 1 1 0 1 1 1 0 KAP family P-loop domain Spc7 PF08317.9 MSTRG.23911.1_1 - 2.2 6.9 22.8 4.2 6.0 7.2 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein CENP-H PF05837.10 MSTRG.23911.1_1 - 3.3 8.0 23.2 0.17 12.2 10.0 2.9 1 1 2 3 3 3 0 Centromere protein H (CENP-H) DUF4407 PF14362.4 MSTRG.23911.1_1 - 4.6 6.4 16.5 7.8 5.6 16.2 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Mnd1 PF03962.13 MSTRG.23911.1_1 - 6.3 6.5 21.2 4.7 6.9 9.1 2.1 1 1 1 2 2 2 0 Mnd1 family FtsJ PF01728.17 MSTRG.5268.1_2 - 5.4e-46 156.8 0.0 7e-46 156.4 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Kunitz_BPTI PF00014.21 MSTRG.8634.1_2 - 7.3e-26 90.0 18.9 3.7e-16 58.9 8.4 3.0 3 0 0 3 3 3 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Lipocalin PF00061.21 MSTRG.8634.1_2 - 1.4e-23 83.6 0.1 1.9e-23 83.1 0.1 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_2 PF08212.10 MSTRG.8634.1_2 - 0.12 12.2 0.1 0.77 9.6 0.1 2.0 1 1 0 1 1 1 0 Lipocalin-like domain Phage_ASH PF10554.7 MSTRG.8634.1_2 - 0.15 12.3 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 Ash protein family RNA_pol_3_Rpc31 PF11705.6 MSTRG.3648.1_2 - 4.8e-26 92.3 9.2 6.6e-26 91.8 9.2 1.1 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 BNIP3 PF06553.10 MSTRG.3648.1_2 - 0.9 9.0 5.9 0.73 9.3 0.1 2.3 2 0 0 2 2 2 0 BNIP3 DUF2457 PF10446.7 MSTRG.3648.1_2 - 0.91 8.5 16.8 1.2 8.1 16.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NOA36 PF06524.10 MSTRG.3648.1_2 - 4.8 6.3 10.3 1.8 7.8 7.8 1.4 2 0 0 2 2 2 0 NOA36 protein LSM14 PF12701.5 MSTRG.26164.1_2 - 6.8e-29 99.6 0.0 1.1e-28 98.9 0.0 1.4 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.8 MSTRG.26164.1_2 - 1.2e-11 45.3 3.4 1.2e-11 45.3 3.4 2.4 2 0 0 2 2 2 1 FDF domain SM-ATX PF14438.4 MSTRG.26164.1_2 - 8.7e-07 28.9 0.0 1.8e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Ataxin 2 SM domain Mei5 PF10376.7 MSTRG.26164.1_2 - 1.4 8.6 9.1 2.5 7.8 9.1 1.3 1 0 0 1 1 1 0 Double-strand recombination repair protein Pkinase PF00069.23 MSTRG.10322.3_3 - 2.2e-49 168.1 0.2 2.9e-49 167.7 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.10322.3_3 - 2e-22 79.6 0.2 1.3e-21 76.9 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Spo7_2_N PF15407.4 MSTRG.10322.3_3 - 0.085 12.4 0.0 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 Sporulation protein family 7 RRM_1 PF00076.20 MSTRG.24557.2_3 - 5.6e-08 32.4 0.0 1e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Serpin PF00079.18 MSTRG.25341.1_3 - 1.3e-126 422.8 17.9 1.1e-125 419.6 17.9 1.9 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) PID PF00640.21 MSTRG.12345.1_3 - 4.5e-19 68.7 0.1 6e-19 68.3 0.1 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH3_9 PF14604.4 MSTRG.12345.1_3 - 1.2e-06 28.1 0.0 2.2e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain PID_2 PF14719.4 MSTRG.12345.1_3 - 8e-05 22.4 0.0 0.0001 22.1 0.0 1.1 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH3_1 PF00018.26 MSTRG.12345.1_3 - 0.00024 20.5 0.0 0.00039 19.8 0.0 1.4 1 0 0 1 1 1 1 SH3 domain DUF1446 PF07287.9 MSTRG.24502.1_2 - 2.7e-115 384.7 0.0 3.6e-115 384.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1446) USP7_ICP0_bdg PF12436.6 MSTRG.4024.1_2 - 8.4e-74 247.8 0.1 4.4e-73 245.5 0.0 2.1 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.4 MSTRG.4024.1_2 - 3.2e-62 209.8 3.4 1.1e-60 204.7 1.8 2.7 3 0 0 3 3 3 1 Ubiquitin-specific protease C-terminal UCH PF00443.27 MSTRG.4024.1_2 - 6e-48 163.4 0.3 1.1e-47 162.5 0.3 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 MSTRG.4024.1_2 - 1.7e-19 70.5 0.0 5.1e-19 68.9 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.24 MSTRG.4024.1_2 - 4e-16 59.0 0.8 2.8e-15 56.3 0.3 2.6 2 0 0 2 2 2 1 MATH domain Annexin PF00191.18 MSTRG.17864.1_1 - 1.9e-18 66.1 0.1 2.5e-18 65.8 0.1 1.2 1 0 0 1 1 1 1 Annexin Kinesin PF00225.21 MSTRG.6616.1_2 - 4.7e-07 28.9 0.0 7.1e-07 28.3 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 MSTRG.6616.1_2 - 0.00037 20.4 0.0 0.00053 19.8 0.0 1.2 1 0 0 1 1 1 1 Microtubule binding TMA7 PF09072.8 MSTRG.12973.1_3 - 2.6e-27 95.3 21.1 3.2e-27 95.0 21.1 1.1 1 0 0 1 1 1 1 Translation machinery associated TMA7 DUF1582 PF07621.9 MSTRG.24006.2_2 - 0.011 15.5 0.1 0.024 14.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1582) Geminin PF07412.10 MSTRG.85.2_3 - 1.3e-73 246.9 10.4 1.9e-73 246.3 10.4 1.2 1 0 0 1 1 1 1 Geminin Shugoshin_N PF07558.9 MSTRG.85.2_3 - 0.14 11.9 1.9 0.3 10.9 0.6 2.3 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region DivIC PF04977.13 MSTRG.85.2_3 - 0.27 10.9 6.7 0.065 12.9 2.3 2.2 2 0 0 2 2 2 0 Septum formation initiator DUF5094 PF17015.3 MSTRG.85.2_3 - 1.9 8.4 9.5 0.36 10.8 5.4 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5094) DUF972 PF06156.11 MSTRG.85.2_3 - 1.9 9.0 7.9 0.84 10.2 4.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF972) DGF-1_C PF11040.6 MSTRG.85.2_3 - 4.1 7.3 10.6 1.5 8.7 0.0 2.9 3 0 0 3 3 3 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus CTNNB1_binding PF08347.9 MSTRG.7236.2_1 - 8.6e-78 261.0 2.4 1.6e-77 260.2 2.4 1.4 1 0 0 1 1 1 1 N-terminal CTNNB1 binding HMG_box PF00505.17 MSTRG.7236.2_1 - 1.3e-21 76.7 1.5 2.6e-21 75.7 1.5 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 MSTRG.7236.2_1 - 5.7e-08 33.1 0.9 1.4e-07 31.9 0.9 1.7 1 0 0 1 1 1 1 HMG-box domain BTB PF00651.29 MSTRG.27170.1_2 - 2.5e-26 92.0 0.3 3.9e-26 91.3 0.3 1.3 1 0 0 1 1 1 1 BTB/POZ domain Kelch_1 PF01344.23 MSTRG.27170.1_2 - 6.5e-24 83.1 7.3 3.3e-05 23.2 0.1 6.6 6 0 0 6 6 6 5 Kelch motif BACK PF07707.13 MSTRG.27170.1_2 - 7.1e-22 77.3 0.0 1.8e-21 76.1 0.0 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_6 PF13964.4 MSTRG.27170.1_2 - 1.6e-14 53.4 5.1 0.19 11.9 0.0 6.4 3 1 3 6 6 6 5 Kelch motif Kelch_2 PF07646.13 MSTRG.27170.1_2 - 1.5e-12 46.8 4.9 0.0093 15.8 0.0 6.1 5 1 1 6 6 6 4 Kelch motif Kelch_3 PF13415.4 MSTRG.27170.1_2 - 2.7e-09 36.9 5.2 0.018 15.2 0.0 5.4 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_4 PF13418.4 MSTRG.27170.1_2 - 6.2e-07 29.1 5.8 1.8 8.5 0.0 5.8 5 1 1 6 6 6 2 Galactose oxidase, central domain Kelch_5 PF13854.4 MSTRG.27170.1_2 - 0.00096 18.9 0.3 13 5.7 0.0 3.8 4 0 0 4 4 4 2 Kelch motif zf-NOSIP PF15906.3 MSTRG.17909.1_1 - 1.8e-49 165.7 1.9 3.2e-49 164.9 1.9 1.4 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein Rtf2 PF04641.10 MSTRG.17909.1_1 - 3.3e-09 36.4 10.0 6.9e-05 22.2 0.0 2.8 2 1 1 3 3 3 2 Rtf2 RING-finger U-box PF04564.13 MSTRG.17909.1_1 - 1.8e-06 27.9 0.1 0.029 14.4 0.0 2.8 2 1 0 2 2 2 2 U-box domain zf-Nse PF11789.6 MSTRG.17909.1_1 - 0.079 12.7 0.8 0.26 11.0 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit Sulfatase PF00884.21 MSTRG.22432.1_3 - 1.9e-40 139.1 0.0 3.2e-40 138.3 0.0 1.4 1 1 0 1 1 1 1 Sulfatase DUF229 PF02995.15 MSTRG.22432.1_3 - 2.8e-07 29.4 0.1 8.5e-05 21.2 0.1 2.4 2 1 0 2 2 2 2 Protein of unknown function (DUF229) Phosphodiest PF01663.20 MSTRG.22432.1_3 - 0.0004 20.0 0.2 0.0015 18.1 0.0 2.0 2 1 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.16 MSTRG.22432.1_3 - 0.0046 16.2 0.0 0.0077 15.5 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily COX_ARM PF06481.12 MSTRG.22432.1_3 - 0.078 12.8 0.1 3.5 7.5 0.0 2.3 2 0 0 2 2 2 0 COX Aromatic Rich Motif DUF1501 PF07394.10 MSTRG.22432.1_3 - 0.17 10.8 0.0 0.32 9.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Laminin_B PF00052.16 MSTRG.11964.1_2 - 3.9e-33 114.0 0.0 4.9e-33 113.7 0.0 1.1 1 0 0 1 1 1 1 Laminin B (Domain IV) Laminin_EGF PF00053.22 MSTRG.11964.1_2 - 2.2e-12 46.8 29.5 4.1e-07 29.9 21.2 2.5 2 0 0 2 2 2 2 Laminin EGF domain Furin-like_2 PF15913.3 MSTRG.11964.1_2 - 1.9 8.5 16.5 0.45 10.6 0.1 2.5 1 1 1 2 2 2 0 Furin-like repeat, cysteine-rich RVT_1 PF00078.25 MSTRG.14797.1_3 - 1.1e-34 119.8 0.0 1.8e-34 119.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.4 MSTRG.14797.1_3 - 9.5e-12 44.7 0.0 2.4e-11 43.4 0.0 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.21 MSTRG.14797.1_3 - 1.5e-05 25.1 0.0 3.4e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RRM_1 PF00076.20 MSTRG.7926.1_2 - 2.9e-10 39.7 0.0 6.8e-10 38.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 MSTRG.7926.1_2 - 0.016 14.9 0.0 0.041 13.6 0.0 1.6 1 0 0 1 1 1 0 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.4 MSTRG.7926.1_2 - 0.032 14.1 0.0 0.061 13.2 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Endosulfine PF04667.15 MSTRG.7926.1_2 - 0.035 14.1 1.3 0.077 13.0 1.3 1.7 1 0 0 1 1 1 0 cAMP-regulated phosphoprotein/endosulfine conserved region MIP-T3 PF10243.7 MSTRG.7926.1_2 - 2.6 6.6 44.7 0.0046 15.6 33.8 1.7 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 Sugar_tr PF00083.22 MSTRG.19062.1_1 - 6e-103 345.0 24.1 6.9e-103 344.8 24.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 MSTRG.19062.1_1 - 1.3e-18 67.0 31.0 5.5e-13 48.4 11.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.11 MSTRG.19062.1_1 - 0.00043 18.7 10.1 0.0008 17.8 3.6 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.4 MSTRG.19062.1_1 - 0.00068 18.2 13.9 0.0017 16.9 1.0 3.3 3 0 0 3 3 3 3 MFS/sugar transport protein Laminin_G_2 PF02210.22 MSTRG.10914.1_2 - 1.6e-15 57.7 0.0 2.3e-15 57.2 0.0 1.2 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.21 MSTRG.10914.1_2 - 5.3e-06 26.5 0.0 8.5e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Laminin G domain S1FA PF04689.11 MSTRG.10914.1_2 - 0.23 11.5 0.9 0.64 10.1 0.9 1.7 1 0 0 1 1 1 0 DNA binding protein S1FA VCX_VCY PF15231.4 MSTRG.10914.1_3 - 0.061 13.8 0.5 0.1 13.1 0.5 1.2 1 0 0 1 1 1 0 Variable charge X/Y family A2M PF00207.20 MSTRG.27287.3_3 - 4.7e-30 103.2 0.4 2e-29 101.1 0.5 2.1 2 0 0 2 2 2 1 Alpha-2-macroglobulin family Thiol-ester_cl PF10569.7 MSTRG.27287.3_3 - 6.5e-17 60.8 3.4 4.2e-16 58.2 2.3 2.4 2 0 0 2 2 2 1 Alpha-macro-globulin thiol-ester bond-forming region SVA PF05326.9 MSTRG.27287.3_3 - 4.7e-07 29.7 0.3 8.6e-07 28.9 0.3 1.4 1 0 0 1 1 1 1 Seminal vesicle autoantigen (SVA) A2M_comp PF07678.12 MSTRG.27287.3_3 - 8.1e-05 22.0 0.4 0.00012 21.5 0.4 1.2 1 0 0 1 1 1 1 A-macroglobulin complement component TOM6p PF15184.4 MSTRG.27287.3_3 - 0.073 12.7 0.2 0.19 11.4 0.2 1.6 1 0 0 1 1 1 0 Mitochondrial import receptor subunit TOM6 homolog Peptidase_C14 PF00656.20 MSTRG.12045.1_3 - 6.6e-42 144.0 0.0 1.1e-41 143.3 0.0 1.4 1 0 0 1 1 1 1 Caspase domain DED PF01335.19 MSTRG.12045.1_3 - 2.8e-35 120.3 10.3 7.2e-21 74.1 1.1 2.6 3 0 0 3 3 3 2 Death effector domain Pox_VLTF3 PF04947.12 MSTRG.12045.1_3 - 0.052 13.1 0.0 1.4 8.4 0.0 2.3 2 0 0 2 2 2 0 Poxvirus Late Transcription Factor VLTF3 like CytochromB561_N PF09786.7 MSTRG.29548.1_3 - 0.084 11.7 0.9 0.12 11.2 0.1 1.6 1 1 1 2 2 2 0 Cytochrome B561, N terminal Tachykinin PF02202.14 MSTRG.25196.1_1 - 8e-05 22.0 1.8 0.08 12.7 0.0 3.2 3 0 0 3 3 3 2 Tachykinin family DAGAT PF03982.11 MSTRG.22756.1_2 - 7.9e-127 422.1 0.0 1e-126 421.7 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Sec23_trunk PF04811.13 MSTRG.387.1_2 - 7.3e-91 303.9 0.1 1e-90 303.5 0.1 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.13 MSTRG.387.1_2 - 1.2e-25 89.2 0.1 2.2e-25 88.3 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.10 MSTRG.387.1_2 - 2.2e-18 66.6 0.1 4.5e-18 65.7 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.13 MSTRG.387.1_2 - 2.5e-14 52.9 8.5 8.5e-14 51.2 8.5 2.0 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.20 MSTRG.387.1_2 - 1.4e-09 37.6 0.0 4.5e-09 36.0 0.0 1.8 2 0 0 2 2 2 1 Gelsolin repeat UNC45-central PF11701.6 MSTRG.5693.2_3 - 6.9e-39 133.1 0.2 1.4e-37 128.8 0.0 2.3 2 0 0 2 2 2 1 Myosin-binding striated muscle assembly central TPR_1 PF00515.26 MSTRG.5693.2_3 - 1.9e-14 52.6 5.3 1e-05 25.0 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.5693.2_3 - 1.6e-13 49.5 1.2 0.00016 21.4 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.5693.2_3 - 6.6e-08 32.0 5.3 0.0085 16.1 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.5693.2_3 - 9.3e-08 31.5 1.4 8.8e-05 22.0 0.0 2.5 2 0 0 2 2 2 2 TPR repeat TPR_12 PF13424.4 MSTRG.5693.2_3 - 6.9e-05 22.9 0.2 0.0023 18.1 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat Arm PF00514.21 MSTRG.5693.2_3 - 0.0012 18.6 0.0 0.012 15.5 0.0 2.6 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat TPR_14 PF13428.4 MSTRG.5693.2_3 - 0.0016 19.0 0.0 4.8 8.1 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat Cast PF10174.7 MSTRG.5693.2_3 - 0.005 15.0 4.0 0.0072 14.5 4.0 1.1 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone TPR_9 PF13371.4 MSTRG.5693.2_3 - 0.0064 16.5 0.0 0.74 9.9 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.5693.2_3 - 0.017 15.0 0.0 0.064 13.2 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.5693.2_3 - 0.092 13.1 1.4 1.4 9.3 0.9 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat BLM10_mid PF16507.3 MSTRG.5693.2_3 - 0.11 11.0 0.0 0.21 10.1 0.0 1.4 1 0 0 1 1 1 0 Proteasome-substrate-size regulator, mid region Clathrin_bdg PF15045.4 MSTRG.19342.1_2 - 1.5e-11 44.0 0.0 2.7e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Clathrin-binding box of Aftiphilin, vesicle trafficking WD40 PF00400.30 MSTRG.4759.1_2 - 0.00022 21.8 0.2 0.094 13.5 0.0 3.4 3 0 0 3 3 3 2 WD domain, G-beta repeat Chorion_2 PF03964.13 MSTRG.4759.1_2 - 0.026 15.2 3.3 0.061 14.0 1.9 2.2 2 0 0 2 2 2 0 Chorion family 2 C1-set PF07654.13 MSTRG.1025.3_1 - 7.5e-24 83.9 0.1 1.5e-23 82.9 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain C2-set_2 PF08205.10 MSTRG.1025.3_1 - 1.1e-05 25.3 0.0 2e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 MSTRG.1025.3_1 - 0.00025 21.5 0.0 0.00097 19.6 0.0 2.0 1 1 1 2 2 2 1 Immunoglobulin domain DUF758 PF05527.9 MSTRG.17452.2_2 - 1.1e-71 240.4 5.0 1.4e-71 240.1 5.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF758) bZIP_1 PF00170.19 MSTRG.24923.1_2 - 5 7.2 18.8 0.054 13.5 10.9 1.8 2 0 0 2 2 2 0 bZIP transcription factor ZapB PF06005.10 MSTRG.24923.1_3 - 0.006 16.9 0.9 0.0095 16.2 0.9 1.4 1 0 0 1 1 1 1 Cell division protein ZapB IncA PF04156.12 MSTRG.24923.1_3 - 0.024 14.3 6.7 0.04 13.6 6.3 1.4 1 1 0 1 1 1 0 IncA protein CLZ PF16526.3 MSTRG.24923.1_3 - 0.037 14.2 1.0 0.064 13.5 1.0 1.3 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DMPK_coil PF08826.8 MSTRG.24923.1_3 - 0.054 13.5 2.0 0.12 12.4 2.0 1.6 1 0 0 1 1 1 0 DMPK coiled coil domain like DUF5082 PF16888.3 MSTRG.24923.1_3 - 0.11 12.7 1.0 0.18 12.0 1.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) bZIP_Maf PF03131.15 MSTRG.24923.1_3 - 1.4 9.4 11.3 0.059 13.8 4.4 2.1 2 0 0 2 2 2 0 bZIP Maf transcription factor bZIP_1 PF00170.19 MSTRG.24923.1_3 - 1.4 9.0 10.3 0.17 11.8 4.0 2.2 2 0 0 2 2 2 0 bZIP transcription factor DICT PF10069.7 MSTRG.14340.1_2 - 0.028 14.1 0.8 0.056 13.1 0.8 1.6 1 1 0 1 1 1 0 Sensory domain in DIguanylate Cyclases and Two-component system FliN_N PF16973.3 MSTRG.14340.1_2 - 0.041 13.6 0.0 0.15 11.8 0.0 1.9 1 0 0 1 1 1 0 Flagellar motor switch protein FliN N-terminal YukD PF08817.8 MSTRG.24211.3_1 - 0.02 15.4 0.1 0.037 14.6 0.1 1.4 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD UN_NPL4 PF11543.6 MSTRG.24211.3_1 - 0.033 14.5 0.0 0.086 13.2 0.0 1.7 1 1 0 1 1 1 0 Nuclear pore localisation protein NPL4 IPPT PF01715.15 MSTRG.11235.1_1 - 6.3e-44 150.4 0.0 1e-43 149.7 0.0 1.2 1 0 0 1 1 1 1 IPP transferase zf-C2H2_jaz PF12171.6 MSTRG.11235.1_1 - 3.1e-06 27.2 0.2 3.1e-06 27.2 0.2 2.8 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.11235.1_1 - 0.0002 21.5 0.1 0.0002 21.5 0.1 2.3 2 0 0 2 2 2 1 Zinc-finger of C2H2 type BAR_3 PF16746.3 MSTRG.17669.2_1 - 5.2e-29 101.5 8.0 8e-29 100.9 8.0 1.3 1 0 0 1 1 1 1 BAR domain of APPL family BAR PF03114.16 MSTRG.17669.2_1 - 2.6e-09 37.0 3.9 2.6e-09 37.0 3.9 1.6 1 1 0 1 1 1 1 BAR domain YscO PF07321.10 MSTRG.17669.2_1 - 0.01 15.6 2.2 0.01 15.6 2.2 2.1 2 0 0 2 2 2 0 Type III secretion protein YscO Snapin_Pallidin PF14712.4 MSTRG.17669.2_1 - 0.039 14.3 3.4 0.19 12.1 3.4 2.2 1 0 0 1 1 1 0 Snapin/Pallidin TEX13 PF15186.4 MSTRG.17669.2_1 - 0.26 10.8 7.9 1 8.9 1.5 2.3 2 0 0 2 2 2 0 Testis-expressed sequence 13 protein family DUF4404 PF14357.4 MSTRG.17669.2_1 - 0.3 11.7 9.2 0.22 12.1 5.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) STN1_2 PF09170.8 MSTRG.17669.2_1 - 0.4 10.8 6.4 0.13 12.3 2.9 2.0 2 1 0 2 2 2 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 Prefoldin PF02996.15 MSTRG.17669.2_1 - 2.5 7.9 9.5 1.4 8.7 0.8 2.7 3 0 0 3 3 3 0 Prefoldin subunit Fib_alpha PF08702.8 MSTRG.17669.2_1 - 4.2 7.4 12.1 0.44 10.6 3.5 2.9 2 1 0 3 3 3 0 Fibrinogen alpha/beta chain family SOUL PF04832.10 MSTRG.27708.1_3 - 4.6e-41 140.6 0.2 6.3e-41 140.2 0.2 1.2 1 0 0 1 1 1 1 SOUL heme-binding protein Pkinase_Tyr PF07714.15 MSTRG.1239.4_2 - 4.9e-102 340.5 0.0 1.1e-101 339.4 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.1239.4_2 - 8.1e-45 153.1 0.0 1.3e-44 152.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 MSTRG.1239.4_2 - 7e-38 128.5 0.0 8.2e-16 57.7 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.1239.4_2 - 5.8e-34 116.4 0.0 1.2e-12 48.2 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.1239.4_2 - 7.8e-27 93.3 0.0 4.6e-10 39.6 0.0 3.7 3 1 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 MSTRG.1239.4_2 - 1.1e-22 79.9 0.4 4.7e-08 32.9 0.0 3.9 4 0 0 4 4 4 3 Immunoglobulin domain V-set PF07686.15 MSTRG.1239.4_2 - 5e-16 58.7 0.6 9.1e-05 22.4 0.0 4.6 3 2 0 3 3 3 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 MSTRG.1239.4_2 - 0.0039 17.1 1.4 0.025 14.5 0.0 2.9 4 0 0 4 4 4 1 CD80-like C2-set immunoglobulin domain RRM_1 PF00076.20 MSTRG.27472.1_2 - 6.5e-12 45.0 0.0 4.6e-09 35.8 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.22 MSTRG.27472.1_2 - 2e-07 31.5 0.0 3.7e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Exonuclease TANGO2 PF05742.10 MSTRG.16613.1_1 - 4.1e-74 249.7 0.0 5e-74 249.4 0.0 1.1 1 0 0 1 1 1 1 Transport and Golgi organisation 2 CD225 PF04505.10 MSTRG.171.1_2 - 7.1e-19 67.6 0.5 1.3e-18 66.8 0.5 1.4 1 0 0 1 1 1 1 Interferon-induced transmembrane protein Peptidase_M1 PF01433.18 MSTRG.5675.2_2 - 5.8e-71 239.7 0.6 6.8e-71 239.5 0.6 1.1 1 0 0 1 1 1 1 Peptidase family M1 zf-CCCH PF00642.22 MSTRG.25958.1_3 - 1.4e-26 91.7 34.1 3.8e-08 32.9 0.8 4.2 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.3 MSTRG.25958.1_3 - 1.1e-05 25.9 27.5 0.0056 17.2 2.4 4.2 1 1 3 4 4 4 4 Torus domain oligo_HPY PF08352.10 MSTRG.25958.1_3 - 0.51 10.8 20.9 1.2 9.5 0.2 4.2 2 1 2 4 4 4 0 Oligopeptide/dipeptide transporter, C-terminal region zf-CCCH_2 PF14608.4 MSTRG.25958.1_3 - 0.61 10.5 41.8 0.21 12.0 3.4 5.4 6 0 0 6 6 6 0 RNA-binding, Nab2-type zinc finger P_proprotein PF01483.18 MSTRG.13718.2_3 - 5.1e-31 106.4 0.4 9.9e-31 105.5 0.4 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain Proho_convert PF12177.6 MSTRG.13718.2_3 - 5.3e-23 80.6 2.5 5.3e-23 80.6 2.5 2.1 3 0 0 3 3 3 1 Prohormone convertase enzyme ANAPC4_WD40 PF12894.5 MSTRG.20338.1_3 - 9.8e-12 44.9 0.1 0.044 13.9 0.0 5.6 3 1 3 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 MSTRG.20338.1_3 - 1e-08 35.5 8.3 2.1e-06 28.2 0.1 5.3 6 0 0 6 6 6 2 WD domain, G-beta repeat eIF2A PF08662.9 MSTRG.20338.1_3 - 2.1e-06 27.6 0.0 0.096 12.4 0.0 3.4 2 2 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.10 MSTRG.20338.1_3 - 3.3e-05 23.6 0.1 0.32 10.9 0.0 3.3 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat DUF4613 PF15390.4 MSTRG.20338.1_3 - 0.25 9.5 7.8 2.3 6.3 0.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4613) Calponin PF00402.16 MSTRG.12183.1_2 - 1.4e-36 123.6 30.0 1.2e-15 56.7 1.9 3.8 4 0 0 4 4 4 3 Calponin family repeat CH PF00307.29 MSTRG.12183.1_2 - 1.9e-21 76.2 0.3 2.7e-21 75.6 0.3 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 MSTRG.12183.1_2 - 0.035 13.8 0.0 0.071 12.8 0.0 1.5 1 0 0 1 1 1 0 CAMSAP CH domain H-K_ATPase_N PF09040.9 MSTRG.12787.1_2 - 1 9.8 6.8 1.3 9.4 6.8 1.2 1 0 0 1 1 1 0 Gastric H+/K+-ATPase, N terminal domain Septin PF00735.16 MSTRG.12151.8_1 - 8.8e-11 41.4 0.0 1.2e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 Septin DUF258 PF03193.14 MSTRG.12151.8_1 - 0.00049 19.9 0.0 0.00069 19.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.4 MSTRG.12151.8_1 - 0.0048 16.4 0.0 0.0076 15.8 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.21 MSTRG.12151.8_1 - 0.0067 16.4 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.4 MSTRG.12151.8_1 - 0.0086 16.3 0.0 0.012 15.8 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.25 MSTRG.12151.8_1 - 0.0098 16.3 0.0 0.015 15.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.4 MSTRG.12151.8_1 - 0.012 15.8 0.0 0.019 15.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.21 MSTRG.12151.8_1 - 0.035 14.0 0.0 0.044 13.7 0.0 1.2 1 0 0 1 1 1 0 Dynamin family Roc PF08477.11 MSTRG.12151.8_1 - 0.094 12.8 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Pox_A32 PF04665.10 MSTRG.12151.8_1 - 0.11 11.8 0.1 0.15 11.4 0.1 1.1 1 0 0 1 1 1 0 Poxvirus A32 protein IIGP PF05049.11 MSTRG.12151.8_1 - 0.12 11.2 0.0 0.17 10.8 0.0 1.1 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) NACHT PF05729.10 MSTRG.12151.8_1 - 0.16 11.8 0.1 0.24 11.2 0.1 1.2 1 0 0 1 1 1 0 NACHT domain AIG1 PF04548.14 MSTRG.12151.8_1 - 0.16 11.1 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 AIG1 family 7tm_1 PF00001.19 MSTRG.14788.2_3 - 4.1e-36 124.5 18.1 5.8e-36 124.0 18.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 MSTRG.14788.2_3 - 0.063 12.9 18.4 0.17 11.5 18.4 1.7 1 1 0 1 1 1 0 Olfactory receptor AIRS_C PF02769.20 MSTRG.20453.1_2 - 1.2e-27 96.8 0.1 1.8e-27 96.3 0.1 1.3 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.22 MSTRG.20453.1_2 - 3.1e-10 40.4 0.1 8e-10 39.1 0.1 1.6 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain ABG_transport PF03806.11 MSTRG.9325.1_1 - 0.079 11.0 0.1 0.1 10.7 0.1 1.1 1 0 0 1 1 1 0 AbgT putative transporter family Pkinase PF00069.23 MSTRG.16250.1_1 - 1.7e-73 247.1 0.0 2.4e-73 246.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.16250.1_1 - 1.2e-34 119.6 0.0 1.8e-34 119.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.16250.1_1 - 0.00068 18.9 0.0 0.0025 17.0 0.0 1.9 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.12 MSTRG.16250.1_1 - 0.083 12.1 0.1 0.16 11.2 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_M16 PF00675.18 MSTRG.15197.5_2 - 3e-15 56.4 0.0 4.5e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Kelch_1 PF01344.23 MSTRG.7601.1_2 - 4.9e-24 83.5 10.9 3.5e-10 39.2 0.5 5.6 5 1 0 5 5 5 4 Kelch motif Kelch_6 PF13964.4 MSTRG.7601.1_2 - 4.5e-20 71.0 0.1 2.4e-06 27.5 0.0 4.0 2 1 1 3 3 3 3 Kelch motif BTB PF00651.29 MSTRG.7601.1_2 - 2.8e-16 59.6 0.0 5.4e-16 58.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_2 PF07646.13 MSTRG.7601.1_2 - 5.5e-11 41.8 1.5 9.4e-05 22.1 0.1 3.9 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.4 MSTRG.7601.1_2 - 1.3e-06 28.4 0.8 6.9e-05 22.9 0.0 3.7 3 1 0 3 3 3 1 Galactose oxidase, central domain Kelch_4 PF13418.4 MSTRG.7601.1_2 - 0.00026 20.7 1.4 0.11 12.4 0.0 4.0 2 1 1 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.4 MSTRG.7601.1_2 - 0.15 12.0 1.9 20 5.1 0.1 3.3 3 0 0 3 3 3 0 Kelch motif BACK PF07707.13 MSTRG.7601.1_2 - 0.32 11.0 1.7 0.34 10.9 0.0 1.9 2 0 0 2 2 2 0 BTB And C-terminal Kelch HIT PF01230.21 MSTRG.1379.1_2 - 2e-26 92.4 0.1 3.1e-26 91.8 0.1 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.6 MSTRG.1379.1_2 - 4.3e-07 30.3 0.0 6.3e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding RINGv PF12906.5 MSTRG.18809.1_1 - 4.9e-14 52.1 7.7 4.9e-14 52.1 7.7 2.4 2 0 0 2 2 2 1 RING-variant domain zf-ANAPC11 PF12861.5 MSTRG.18809.1_1 - 0.017 15.0 1.1 0.017 15.0 1.1 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Vpu PF00558.17 MSTRG.18809.1_1 - 0.096 12.3 0.3 0.19 11.4 0.3 1.4 1 0 0 1 1 1 0 Vpu protein PAN_4 PF14295.4 MSTRG.18809.1_3 - 0.076 12.8 1.7 0.19 11.5 1.7 1.6 1 0 0 1 1 1 0 PAN domain Syntaxin_2 PF14523.4 MSTRG.18848.2_2 - 6.1e-31 106.6 16.7 5.4e-30 103.6 11.5 2.3 2 0 0 2 2 2 2 Syntaxin-like protein SNARE PF05739.17 MSTRG.18848.2_2 - 1.4e-20 72.9 0.3 3.4e-20 71.7 0.3 1.7 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.23 MSTRG.18848.2_2 - 2.5e-13 50.0 14.9 4.3e-13 49.3 14.9 1.4 1 0 0 1 1 1 1 Syntaxin Spore_III_AB PF09548.8 MSTRG.18848.2_2 - 0.082 12.9 0.2 0.082 12.9 0.2 2.9 2 1 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) MitMem_reg PF13012.4 MSTRG.18848.2_2 - 0.46 10.8 3.6 0.18 12.2 0.8 1.7 2 0 0 2 2 2 0 Maintenance of mitochondrial structure and function DUF1664 PF07889.10 MSTRG.18848.2_2 - 0.52 10.2 8.4 1.5 8.7 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF1359 PF07097.9 MSTRG.18848.2_2 - 0.64 10.2 5.1 2.8 8.1 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1359) Synaptobrevin PF00957.19 MSTRG.18848.2_2 - 0.94 9.2 12.7 0.4 10.4 2.9 3.1 2 1 1 3 3 3 0 Synaptobrevin TMCO5 PF14992.4 MSTRG.18848.2_2 - 4.6 6.6 15.7 1.1 8.7 1.5 2.1 2 0 0 2 2 2 0 TMCO5 family DUF16 PF01519.14 MSTRG.18848.2_2 - 5.7 7.3 9.4 5.9 7.3 2.7 2.5 2 0 0 2 2 2 0 Protein of unknown function DUF16 C2-set_2 PF08205.10 MSTRG.23364.1_3 - 3.5e-13 49.3 0.1 8.6e-13 48.0 0.1 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.4 MSTRG.23364.1_3 - 8.1e-12 45.2 0.1 9.1e-06 25.8 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.23364.1_3 - 3.8e-11 43.3 0.2 2.1e-05 24.9 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 MSTRG.23364.1_3 - 6.1e-10 39.1 0.1 8.9e-06 25.7 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.23 MSTRG.23364.1_3 - 7.2e-10 38.8 0.2 0.00073 19.5 0.0 3.1 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 MSTRG.23364.1_3 - 9.7e-06 25.4 0.0 0.07 13.1 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin I-set domain C1-set PF07654.13 MSTRG.23364.1_3 - 0.033 14.5 0.0 0.079 13.3 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin C1-set domain LysM PF01476.18 MSTRG.16404.2_2 - 0.00013 21.9 0.0 0.00022 21.1 0.0 1.4 1 0 0 1 1 1 1 LysM domain PRIMA1 PF16101.3 MSTRG.16404.2_2 - 2.8 7.9 7.4 9.1 6.2 7.4 1.8 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 TLD PF07534.14 MSTRG.16404.2_3 - 8.8e-35 119.8 0.0 1.4e-34 119.2 0.0 1.3 1 0 0 1 1 1 1 TLD GRAM PF02893.18 MSTRG.16404.2_3 - 0.085 12.6 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 GRAM domain Syntaxin PF00804.23 MSTRG.15803.3_3 - 1.9e-59 200.6 15.0 3.2e-59 199.8 15.0 1.4 1 0 0 1 1 1 1 Syntaxin Syntaxin_2 PF14523.4 MSTRG.15803.3_3 - 5.6e-10 39.4 6.5 5.6e-10 39.4 6.5 2.0 2 0 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.17 MSTRG.15803.3_3 - 6.8e-10 38.7 3.1 6.8e-10 38.7 3.1 3.8 4 0 0 4 4 4 1 SNARE domain DUF2207 PF09972.7 MSTRG.15803.3_3 - 0.012 14.4 0.2 0.012 14.4 0.2 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) AAA_13 PF13166.4 MSTRG.15803.3_3 - 0.052 12.1 15.8 0.071 11.6 15.8 1.1 1 0 0 1 1 1 0 AAA domain FlaC_arch PF05377.9 MSTRG.15803.3_3 - 0.14 12.4 0.2 0.14 12.4 0.2 3.6 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF3040 PF11239.6 MSTRG.15803.3_3 - 0.16 12.1 4.9 0.23 11.6 1.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Nup54 PF13874.4 MSTRG.15803.3_3 - 0.44 10.5 10.1 0.097 12.6 3.8 2.4 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 DUF5082 PF16888.3 MSTRG.15803.3_3 - 0.54 10.5 8.2 3 8.1 2.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) Baculo_PEP_C PF04513.10 MSTRG.15803.3_3 - 3.5 7.5 6.7 1.3 8.9 2.0 2.2 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TMPIT PF07851.11 MSTRG.15803.3_3 - 7.2 5.6 6.7 5.3 6.0 2.4 2.1 2 0 0 2 2 2 0 TMPIT-like protein Fib_alpha PF08702.8 MSTRG.15803.3_3 - 8.9 6.4 13.4 0.82 9.7 4.8 2.7 2 2 1 3 3 3 0 Fibrinogen alpha/beta chain family GTP_EFTU_D3 PF03143.15 MSTRG.16988.1_2 - 0.11 12.6 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu C-terminal domain Na_sulph_symp PF00939.17 MSTRG.16988.1_3 - 1.1e-131 440.0 17.5 1.3e-131 439.7 17.5 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.14 MSTRG.16988.1_3 - 3.2e-34 118.4 21.5 4.4e-21 75.3 0.1 3.1 2 1 1 3 3 3 2 Citrate transporter Glyco_transf_10 PF00852.17 MSTRG.8788.1_1 - 1.9e-67 226.3 5.8 2.9e-67 225.7 5.8 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.3 MSTRG.8788.1_1 - 4.9e-37 126.6 0.0 1e-36 125.6 0.0 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal DHC_N1 PF08385.10 MSTRG.18371.2_1 - 9.3e-134 447.0 10.0 9.3e-134 447.0 10.0 4.3 5 1 0 5 5 4 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.11 MSTRG.18371.2_1 - 1.8e-113 379.5 16.7 1.8e-113 379.5 16.7 5.2 5 1 0 5 5 4 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.5 MSTRG.18371.2_1 - 1.5e-78 263.6 0.0 5.7e-78 261.7 0.0 2.0 2 0 0 2 2 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_9 PF12781.5 MSTRG.18371.2_1 - 3.7e-73 245.2 0.5 2.4e-72 242.5 0.1 2.9 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 AAA_8 PF12780.5 MSTRG.18371.2_1 - 1.2e-44 152.4 0.0 5.8e-44 150.1 0.0 2.2 1 1 0 1 1 1 1 P-loop containing dynein motor region D4 MT PF12777.5 MSTRG.18371.2_1 - 2.4e-39 135.2 15.1 4e-39 134.5 15.1 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.12 MSTRG.18371.2_1 - 5e-30 104.2 0.0 1.1e-12 47.9 0.0 5.4 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.13 MSTRG.18371.2_1 - 6.4e-23 80.8 1.0 1.5e-22 79.5 0.0 2.1 2 0 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor AAA_7 PF12775.5 MSTRG.18371.2_1 - 6.5e-21 74.7 0.1 2.1e-20 73.1 0.0 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 AAA_22 PF13401.4 MSTRG.18371.2_1 - 6e-14 52.4 4.9 0.015 15.4 0.0 7.0 7 0 0 7 7 6 4 AAA domain AAA PF00004.27 MSTRG.18371.2_1 - 2e-13 50.8 0.0 0.054 13.8 0.0 5.1 4 0 0 4 4 4 3 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.4 MSTRG.18371.2_1 - 8.8e-11 42.0 0.0 0.035 14.1 0.0 5.4 4 0 0 4 4 4 3 AAA domain AAA_16 PF13191.4 MSTRG.18371.2_1 - 3.4e-10 40.4 0.1 1.9 8.7 0.0 6.9 7 0 0 7 7 6 3 AAA ATPase domain AAA_18 PF13238.4 MSTRG.18371.2_1 - 5.4e-09 36.5 2.1 0.083 13.3 0.0 5.8 5 0 0 5 5 4 2 AAA domain Mg_chelatase PF01078.19 MSTRG.18371.2_1 - 9.7e-07 28.2 0.5 0.1 11.9 0.0 3.8 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_30 PF13604.4 MSTRG.18371.2_1 - 3.2e-05 23.6 0.8 6.4 6.3 0.0 4.5 4 0 0 4 4 4 0 AAA domain T2SSE PF00437.18 MSTRG.18371.2_1 - 0.00012 21.1 0.0 0.18 10.7 0.0 3.5 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_19 PF13245.4 MSTRG.18371.2_1 - 0.00015 22.0 0.8 0.26 11.5 0.0 4.7 4 0 0 4 4 4 1 AAA domain ABC_tran PF00005.25 MSTRG.18371.2_1 - 0.00017 22.0 1.2 4.4 7.7 0.0 5.1 4 0 0 4 4 4 1 ABC transporter IstB_IS21 PF01695.15 MSTRG.18371.2_1 - 0.00018 21.2 0.3 0.21 11.2 0.0 4.3 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_29 PF13555.4 MSTRG.18371.2_1 - 0.0013 18.3 0.0 2.5 7.7 0.0 3.5 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_24 PF13479.4 MSTRG.18371.2_1 - 0.0015 18.1 0.2 31 4.1 0.0 4.7 4 0 0 4 4 4 0 AAA domain FtsK_SpoIIIE PF01580.16 MSTRG.18371.2_1 - 0.008 15.4 0.0 4.1 6.6 0.0 3.7 3 0 0 3 3 3 1 FtsK/SpoIIIE family RNA_helicase PF00910.20 MSTRG.18371.2_1 - 0.0093 16.2 0.2 31 4.9 0.0 4.9 6 0 0 6 6 4 0 RNA helicase AAA_25 PF13481.4 MSTRG.18371.2_1 - 0.019 14.4 0.2 0.52 9.7 0.0 3.4 3 0 0 3 3 3 0 AAA domain ERM PF00769.17 MSTRG.18371.2_1 - 0.037 13.7 37.1 0.03 14.0 6.3 3.4 3 0 0 3 3 2 0 Ezrin/radixin/moesin family TsaE PF02367.15 MSTRG.18371.2_1 - 0.04 13.8 1.1 13 5.6 0.0 3.8 4 0 0 4 4 4 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Dynein_heavy PF03028.13 MSTRG.18371.2_2 - 3.4e-112 375.9 0.0 4.4e-112 375.5 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor Lipocalin PF00061.21 MSTRG.14299.1_2 - 1e-18 67.8 0.6 1.3e-18 67.4 0.6 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 MSTRG.14299.1_2 - 3.8e-06 26.7 0.0 5.6e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family MAM PF00629.21 MSTRG.24412.2_1 - 1.9e-44 151.2 1.7 3e-44 150.6 1.7 1.3 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu VWD PF00094.23 MSTRG.24412.2_1 - 5.1e-23 81.9 0.0 4.5e-21 75.6 0.0 2.3 1 1 0 1 1 1 1 von Willebrand factor type D domain TIL PF01826.15 MSTRG.24412.2_1 - 6e-11 42.3 14.2 6e-11 42.3 14.2 3.9 3 0 0 3 3 1 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.5 MSTRG.24412.2_1 - 3.7e-05 23.5 12.5 3.7e-05 23.5 12.5 3.9 5 0 0 5 5 4 1 TILa domain Sigma70_ner PF04546.11 MSTRG.24412.2_1 - 0.2 11.4 2.7 0.32 10.7 2.7 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region RXT2_N PF08595.9 MSTRG.24412.2_1 - 0.98 9.3 4.6 1.8 8.4 4.6 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal YL1 PF05764.11 MSTRG.24412.2_1 - 1.3 9.0 4.7 1.9 8.4 4.7 1.2 1 0 0 1 1 1 0 YL1 nuclear protein TFB6 PF17110.3 MSTRG.24412.2_1 - 1.5 8.4 3.3 2.5 7.7 3.3 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH CDC45 PF02724.12 MSTRG.24412.2_1 - 2.3 6.3 3.7 3.4 5.7 3.7 1.1 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.4 MSTRG.24412.2_1 - 3 7.4 4.2 8.2 6.0 4.2 1.6 1 0 0 1 1 1 0 FAM176 family DNA_pol_phi PF04931.11 MSTRG.24412.2_1 - 3.8 5.4 9.0 5.3 4.9 9.0 1.0 1 0 0 1 1 1 0 DNA polymerase phi RRN3 PF05327.9 MSTRG.24412.2_1 - 5.6 5.2 5.1 8 4.7 5.1 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 MAM PF00629.21 MSTRG.24412.2_2 - 8.9e-140 461.1 18.2 2.3e-45 154.2 0.8 4.5 4 0 0 4 4 4 4 MAM domain, meprin/A5/mu VWD PF00094.23 MSTRG.24412.2_2 - 1e-66 224.0 5.5 1.4e-34 119.5 1.6 2.7 2 0 0 2 2 2 2 von Willebrand factor type D domain C8 PF08742.9 MSTRG.24412.2_2 - 4.5e-30 103.7 17.7 2.4e-15 56.6 1.0 3.8 3 0 0 3 3 3 2 C8 domain TILa PF12714.5 MSTRG.24412.2_2 - 1.2e-08 34.7 11.7 1.2e-08 34.7 11.7 4.5 2 1 1 3 3 3 2 TILa domain TIL PF01826.15 MSTRG.24412.2_2 - 9.9e-06 25.6 19.6 9.9e-06 25.6 19.6 5.9 5 0 0 5 5 5 1 Trypsin Inhibitor like cysteine rich domain PDZ PF00595.22 MSTRG.18703.3_3 - 1.3e-26 92.6 1.3 3.8e-12 46.2 0.1 2.2 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.18703.3_3 - 7.6e-08 32.4 0.3 0.0033 17.6 0.0 2.4 2 0 0 2 2 2 2 PDZ domain EF-hand_1 PF00036.30 MSTRG.17999.1_2 - 2.6e-40 132.8 9.6 3.2e-09 35.5 0.4 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 MSTRG.17999.1_2 - 1e-34 118.7 2.7 6.6e-18 64.8 0.7 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 MSTRG.17999.1_2 - 5.5e-32 109.2 9.4 4.9e-14 51.7 0.3 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.17999.1_2 - 4.6e-28 94.6 5.7 8.3e-09 34.6 0.1 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.4 MSTRG.17999.1_2 - 9.4e-25 84.9 6.9 6.4e-06 25.3 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.4 MSTRG.17999.1_2 - 9e-14 51.4 0.2 2.8e-08 33.8 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 MSTRG.17999.1_2 - 2.8e-08 33.5 0.2 0.00066 19.5 0.1 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 MSTRG.17999.1_2 - 3.6e-06 27.1 0.0 0.053 13.7 0.0 2.3 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.9 MSTRG.17999.1_2 - 0.00023 21.9 0.0 0.013 16.2 0.0 2.2 1 1 1 2 2 2 1 EF-hand domain EFhand_Ca_insen PF08726.8 MSTRG.17999.1_2 - 0.00044 20.1 0.6 0.001 18.9 0.1 1.9 2 0 0 2 2 2 1 Ca2+ insensitive EF hand UPF0154 PF03672.11 MSTRG.17999.1_2 - 0.0015 18.4 0.0 0.31 11.0 0.0 2.7 2 1 0 2 2 2 1 Uncharacterised protein family (UPF0154) DUF4497 PF14924.4 MSTRG.17999.1_2 - 0.03 14.6 0.0 9.5 6.6 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF4497) DUF1103 PF06513.9 MSTRG.17999.1_2 - 0.034 13.6 2.5 0.048 13.1 2.5 1.2 1 0 0 1 1 1 0 Repeat of unknown function (DUF1103) DUF3349 PF11829.6 MSTRG.17999.1_2 - 0.15 12.7 0.3 13 6.5 0.0 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) RNA_pol_Rpb4 PF03874.14 MSTRG.17999.1_2 - 0.2 11.9 0.5 12 6.2 0.1 2.3 2 0 0 2 2 2 0 RNA polymerase Rpb4 UCR_6-4kD PF08997.8 MSTRG.17999.1_3 - 0.014 15.2 0.3 0.026 14.3 0.3 1.4 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein PRP38 PF03371.13 MSTRG.24972.4_1 - 1.6e-33 115.9 0.0 3.2e-33 114.9 0.0 1.4 1 0 0 1 1 1 1 PRP38 family Pribosyltran PF00156.25 MSTRG.665.3_1 - 4.1e-09 36.0 0.0 4.8e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.4 MSTRG.665.3_1 - 0.0018 17.7 0.0 0.0022 17.3 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DUF4530 PF15039.4 MSTRG.665.3_1 - 0.12 12.4 0.1 0.18 11.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4530) Cactin_mid PF10312.7 MSTRG.24920.1_1 - 7.2e-66 221.5 0.6 7.2e-66 221.5 0.6 2.2 2 1 0 2 2 2 1 Conserved mid region of cactin CactinC_cactus PF09732.7 MSTRG.24920.1_1 - 6.6e-58 193.9 9.5 1.1e-57 193.2 9.5 1.4 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein GILT PF03227.14 MSTRG.18820.1_2 - 7.3e-27 93.5 1.7 1.3e-26 92.8 1.7 1.4 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) TT_ORF2 PF02957.13 MSTRG.16211.1_2 - 3 8.6 5.4 4.8 8.0 4.0 2.0 2 0 0 2 2 2 0 TT viral ORF2 Hira PF07569.9 MSTRG.16211.1_3 - 6.1e-54 183.0 0.2 1.1e-53 182.1 0.2 1.4 1 0 0 1 1 1 1 TUP1-like enhancer of split Mcl1_mid PF12341.6 MSTRG.16211.1_3 - 0.084 12.1 0.1 0.13 11.4 0.1 1.2 1 0 0 1 1 1 0 Minichromosome loss protein, Mcl1, middle region KN_motif PF12075.6 MSTRG.12680.1_2 - 9.9e-22 76.3 0.4 9.9e-22 76.3 0.4 1.8 2 0 0 2 2 2 1 KN motif zf-met PF12874.5 MSTRG.13715.1_1 - 9.8e-27 92.4 23.2 1.2e-08 34.9 0.1 5.0 5 0 0 5 5 5 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.13715.1_1 - 1.5e-17 63.2 10.8 2.3e-06 27.6 0.3 4.5 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-U1 PF06220.10 MSTRG.13715.1_1 - 0.0016 18.0 17.2 0.19 11.4 0.2 4.5 4 0 0 4 4 4 3 U1 zinc finger zf-C2H2_2 PF12756.5 MSTRG.13715.1_1 - 0.0021 18.3 22.4 0.1 12.8 9.0 4.4 2 2 1 3 3 3 1 C2H2 type zinc-finger (2 copies) zf-SCNM1 PF15803.3 MSTRG.13715.1_1 - 0.02 14.4 2.9 14 5.3 0.1 3.9 3 0 0 3 3 3 0 Zinc-finger of sodium channel modifier 1 CO_deh_flav_C PF03450.15 MSTRG.13715.1_1 - 0.1 12.6 0.0 0.29 11.2 0.0 1.7 2 0 0 2 2 2 0 CO dehydrogenase flavoprotein C-terminal domain zf-C2H2_4 PF13894.4 MSTRG.13715.1_1 - 0.92 10.4 8.7 46 5.1 0.0 4.5 4 0 0 4 4 4 0 C2H2-type zinc finger zf-DBF PF07535.10 MSTRG.13715.1_1 - 2.5 8.1 9.7 7.1 6.7 0.1 3.6 4 0 0 4 4 4 0 DBF zinc finger Auto_anti-p27 PF06677.10 MSTRG.13715.1_1 - 3 7.9 7.0 1.5 8.9 0.0 3.1 4 0 0 4 4 4 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-C2H2 PF00096.24 MSTRG.13715.1_1 - 8.1 7.0 12.1 16 6.1 0.1 4.2 4 0 0 4 4 4 0 Zinc finger, C2H2 type adh_short PF00106.23 MSTRG.8539.2_2 - 1.1e-42 145.5 0.0 2.5e-40 137.9 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 MSTRG.8539.2_2 - 9.9e-29 100.4 0.0 8.5e-24 84.3 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 MSTRG.8539.2_2 - 1.6e-08 34.5 0.0 2.8e-08 33.7 0.0 1.3 1 1 0 1 1 1 1 KR domain zf-CXXC PF02008.18 MSTRG.6169.2_3 - 7e-13 48.2 21.9 1.7e-12 47.0 21.9 1.6 1 0 0 1 1 1 1 CXXC zinc finger domain RhoGAP PF00620.25 MSTRG.27609.1_1 - 2.1e-18 66.4 0.0 3.7e-18 65.6 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain CBM_21 PF03370.11 MSTRG.21673.1_1 - 1.7e-24 86.0 0.0 3.3e-24 85.1 0.0 1.5 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.3 MSTRG.21673.1_1 - 2.1e-07 31.3 0.3 1.6e-06 28.4 0.0 2.6 2 0 0 2 2 2 1 Starch/carbohydrate-binding module (family 53) TPR_1 PF00515.26 MSTRG.1459.1_3 - 9.1e-33 110.6 12.1 0.00013 21.5 0.1 9.4 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.1459.1_3 - 7.2e-30 100.5 10.1 0.00041 20.1 0.1 9.9 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.1459.1_3 - 6.8e-24 83.8 17.6 7.9e-07 29.1 0.1 7.9 5 1 4 9 9 9 6 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.1459.1_3 - 5.5e-21 72.8 8.0 0.00045 19.9 0.0 9.2 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.1459.1_3 - 3.5e-18 65.9 2.3 0.00029 21.3 0.1 5.7 4 2 1 6 6 5 3 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.1459.1_3 - 8.8e-17 59.7 19.7 0.0012 18.7 0.0 10.0 11 0 0 11 11 10 4 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.1459.1_3 - 6.3e-15 55.3 11.5 0.00011 22.4 0.7 6.4 4 3 3 7 7 7 5 Tetratricopeptide repeat TPR_6 PF13174.4 MSTRG.1459.1_3 - 2.7e-14 52.6 11.8 2.5 8.8 0.0 10.0 10 0 0 10 10 10 1 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.1459.1_3 - 1.8e-12 46.6 0.6 0.054 13.1 0.0 6.0 5 1 1 6 6 6 4 TPR repeat TPR_14 PF13428.4 MSTRG.1459.1_3 - 2.6e-10 40.1 3.3 0.038 14.7 0.0 7.7 4 3 4 8 8 8 2 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.1459.1_3 - 1.1e-08 34.7 10.4 0.42 11.0 0.1 7.8 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_10 PF13374.4 MSTRG.1459.1_3 - 1.9e-08 33.8 6.6 0.2 11.5 0.1 7.5 8 0 0 8 8 7 2 Tetratricopeptide repeat DUF3808 PF10300.7 MSTRG.1459.1_3 - 1.1e-07 30.8 6.6 1.5e-07 30.4 1.6 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF3808) ANAPC3 PF12895.5 MSTRG.1459.1_3 - 5.9e-07 29.5 17.2 0.0031 17.5 1.5 5.8 3 2 5 8 8 7 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.4 MSTRG.1459.1_3 - 9.7e-07 28.7 0.3 0.77 9.8 0.2 5.0 3 2 3 6 6 6 1 Tetratricopeptide repeat Sel1 PF08238.10 MSTRG.1459.1_3 - 0.00014 22.3 8.8 3.7 8.2 0.1 5.8 5 1 0 5 5 5 1 Sel1 repeat TPR_15 PF13429.4 MSTRG.1459.1_3 - 0.0049 16.0 8.1 0.0055 15.8 2.7 3.3 2 2 0 2 2 2 1 Tetratricopeptide repeat DUF2225 PF09986.7 MSTRG.1459.1_3 - 0.039 13.5 9.7 1 8.9 1.6 3.2 2 2 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_5 PF12688.5 MSTRG.1459.1_3 - 0.071 13.2 0.2 2 8.6 0.0 3.2 3 0 0 3 3 3 0 Tetratrico peptide repeat FumaraseC_C PF10415.7 MSTRG.1459.1_3 - 0.13 12.6 0.3 0.48 10.8 0.0 2.2 2 0 0 2 2 2 0 Fumarase C C-terminus MIT PF04212.16 MSTRG.1459.1_3 - 0.21 11.6 27.0 0.5 10.4 0.1 7.6 9 1 1 10 10 9 0 MIT (microtubule interacting and transport) domain HAP1_N PF04849.11 MSTRG.21441.2_1 - 6.9e-130 432.6 35.4 9e-130 432.3 35.4 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Milton PF12448.6 MSTRG.21441.2_1 - 3.5e-56 189.9 7.2 3.5e-56 189.9 7.2 3.1 2 1 0 2 2 2 1 Kinesin associated protein HOOK PF05622.10 MSTRG.21441.2_1 - 0.1 10.6 27.5 0.17 9.8 27.5 1.3 1 0 0 1 1 1 0 HOOK protein TMF_TATA_bd PF12325.6 MSTRG.21441.2_1 - 1.4 9.1 37.4 0.16 12.1 19.3 3.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding MCPsignal PF00015.19 MSTRG.21441.2_1 - 1.5 8.4 6.2 8 6.0 3.3 2.2 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain KASH_CCD PF14662.4 MSTRG.21441.2_1 - 1.6 8.4 40.2 1.9 8.2 10.1 3.2 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH SH3BP5 PF05276.12 MSTRG.21441.2_1 - 2.8 7.6 22.8 0.54 9.9 16.4 2.1 2 0 0 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) IncA PF04156.12 MSTRG.21441.2_1 - 2.9 7.5 46.9 1.7 8.3 5.8 3.3 2 1 1 3 3 3 0 IncA protein GIT_CC PF16559.3 MSTRG.21441.2_1 - 5.1 7.1 17.3 1.8 8.6 0.1 4.2 3 1 1 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF1664 PF07889.10 MSTRG.21441.2_1 - 9.9 6.0 18.2 0.49 10.3 0.9 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) Hyd_WA PF06462.10 MSTRG.1285.2_3 - 1.5e-10 40.7 0.1 1.4e-05 24.8 0.0 2.7 2 0 0 2 2 2 2 Propeller MyTH4 PF00784.15 MSTRG.14643.1_1 - 7.8e-15 55.2 0.0 1.2e-14 54.5 0.0 1.3 1 0 0 1 1 1 1 MyTH4 domain V-set PF07686.15 MSTRG.4639.1_3 - 0.0004 20.4 0.0 0.00078 19.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain DUF1394 PF07159.10 MSTRG.13314.1_1 - 1.6e-144 480.7 0.2 1.9e-144 480.4 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) V-ATPase_H_N PF03224.12 MSTRG.13314.1_1 - 0.016 14.4 0.0 0.024 13.8 0.0 1.2 1 0 0 1 1 1 0 V-ATPase subunit H DUF667 PF05018.11 MSTRG.20317.1_3 - 4.4e-95 316.5 0.8 5.3e-95 316.2 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF667) DUF5056 PF16479.3 MSTRG.20317.1_3 - 0.25 11.5 2.0 0.67 10.1 2.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5056) Ribosomal_L22e PF01776.15 MSTRG.12994.1_1 - 2.3e-51 172.6 0.6 3.4e-51 172.1 0.6 1.2 1 0 0 1 1 1 1 Ribosomal L22e protein family Bud13 PF09736.7 MSTRG.26144.1_2 - 7.6e-18 65.2 1.5 9.7e-18 64.8 1.5 1.1 1 0 0 1 1 1 1 Pre-mRNA-splicing factor of RES complex CPL PF08144.9 MSTRG.9700.1_1 - 5e-47 159.7 0.0 5e-47 159.7 0.0 4.7 3 2 2 6 6 6 1 CPL (NUC119) domain Bmt2 PF11968.6 MSTRG.9700.1_1 - 0.019 14.7 0.0 0.047 13.4 0.0 1.6 1 0 0 1 1 1 0 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 PUF PF00806.17 MSTRG.9700.1_1 - 0.02 14.5 0.0 0.11 12.1 0.0 2.4 1 0 0 1 1 1 0 Pumilio-family RNA binding repeat cwf18 PF08315.10 MSTRG.9700.1_1 - 5.9 7.4 13.7 13 6.3 13.7 1.6 1 1 0 1 1 1 0 cwf18 pre-mRNA splicing factor FBPase PF00316.18 MSTRG.4949.1_2 - 3.1e-76 255.0 0.2 4.1e-76 254.6 0.2 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.23 MSTRG.4949.1_2 - 0.0011 18.4 0.0 0.0016 17.8 0.0 1.2 1 0 0 1 1 1 1 Inositol monophosphatase family HPS3_C PF14763.4 MSTRG.1752.4_2 - 1.1e-162 541.2 4.5 1.5e-162 540.8 4.5 1.2 1 0 0 1 1 1 1 Hermansky-Pudlak syndrome 3, C-terminal HPS3_Mid PF14762.4 MSTRG.1752.4_2 - 1.6e-158 527.4 0.0 2.3e-158 526.9 0.0 1.2 1 0 0 1 1 1 1 Hermansky-Pudlak syndrome 3, middle region HPS3_N PF14761.4 MSTRG.1752.4_2 - 1.4e-70 237.1 0.0 5.9e-70 235.0 0.0 2.1 2 0 0 2 2 2 1 Hermansky-Pudlak syndrome 3 Pecanex_C PF05041.13 MSTRG.8888.1_1 - 3.8e-114 379.8 0.0 5.4e-114 379.3 0.0 1.2 1 0 0 1 1 1 1 Pecanex protein (C-terminus) SDA1 PF05285.10 MSTRG.27543.2_1 - 3.7 6.8 20.6 5.2 6.3 20.6 1.2 1 0 0 1 1 1 0 SDA1 PPP4R2 PF09184.9 MSTRG.27543.2_1 - 9.1 5.6 19.9 13 5.1 19.9 1.1 1 0 0 1 1 1 0 PPP4R2 BRCT PF00533.24 MSTRG.6850.6_3 - 7.7e-20 71.0 0.0 3.6e-11 43.2 0.0 2.4 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.3 MSTRG.6850.6_3 - 5e-17 62.0 0.0 3.7e-10 39.9 0.0 2.4 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.5 MSTRG.6850.6_3 - 2.1e-11 43.5 0.0 3.8e-09 36.2 0.0 2.3 2 0 0 2 2 2 2 twin BRCT domain LIG3_BRCT PF16759.3 MSTRG.6850.6_3 - 8.8e-06 25.8 0.0 0.00018 21.6 0.0 2.3 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain SLC12 PF03522.13 MSTRG.6850.6_3 - 0.14 11.0 0.2 0.25 10.2 0.2 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Glyco_transf_8 PF01501.18 MSTRG.5111.1_2 - 3.9e-47 160.8 0.0 5e-47 160.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 8 Longin PF13774.4 MSTRG.1489.2_2 - 3.1e-18 65.5 0.1 5.6e-18 64.6 0.1 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain CHORD PF04968.10 MSTRG.7170.1_3 - 0.05 14.2 0.4 0.083 13.5 0.4 1.3 1 0 0 1 1 1 0 CHORD Podoplanin PF05808.9 MSTRG.7170.1_3 - 0.21 11.6 3.3 0.36 10.8 3.3 1.4 1 0 0 1 1 1 0 Podoplanin FAP PF07174.9 MSTRG.7170.1_3 - 0.77 9.0 14.9 1.1 8.5 14.9 1.1 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Lamp PF01299.15 MSTRG.7170.1_3 - 7.8 5.8 16.2 13 5.1 16.2 1.3 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) VHS PF00790.17 MSTRG.2580.2_1 - 2.8e-45 153.5 0.0 4.8e-45 152.7 0.0 1.4 1 0 0 1 1 1 1 VHS domain GAT PF03127.12 MSTRG.2580.2_1 - 1.3e-25 89.4 1.5 2.7e-25 88.4 1.5 1.6 1 0 0 1 1 1 1 GAT domain ENTH PF01417.18 MSTRG.2580.2_1 - 0.081 12.8 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 ENTH domain Glyco_hydro_35 PF01301.17 MSTRG.14884.1_3 - 6.4e-116 387.3 0.1 8e-116 386.9 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.13 MSTRG.14884.1_3 - 1.6e-10 40.8 0.1 1.2e-08 34.6 0.1 2.2 1 1 0 1 1 1 1 Beta-galactosidase BetaGal_dom4_5 PF13364.4 MSTRG.14884.1_3 - 4.8e-07 30.2 0.1 2.1e-06 28.1 0.0 2.1 2 0 0 2 2 2 1 Beta-galactosidase jelly roll domain PI-PLC-Y PF00387.17 MSTRG.21133.1_1 - 4.7e-23 81.6 0.5 8.1e-23 80.9 0.5 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain PI-PLC-X PF00388.17 MSTRG.21133.1_1 - 1.6e-11 43.9 0.0 2.8e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain Y_phosphatase PF00102.25 MSTRG.28732.1_3 - 2.3e-07 30.5 0.0 2.4e-07 30.4 0.0 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Ras PF00071.20 MSTRG.12451.1_2 - 1.2e-56 190.7 0.0 1.4e-56 190.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.12451.1_2 - 3.8e-20 72.2 0.0 5.2e-20 71.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.12451.1_2 - 8.8e-10 38.2 0.0 1.1e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 MSTRG.12451.1_2 - 2.5e-06 27.4 0.1 0.0044 16.8 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 MSTRG.12451.1_2 - 7e-05 22.3 0.2 0.00039 19.9 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 MSTRG.12451.1_2 - 0.0013 18.7 0.0 0.0019 18.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 MSTRG.12451.1_2 - 0.026 13.9 0.1 0.08 12.3 0.1 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.3 MSTRG.12451.1_2 - 0.049 13.6 0.0 0.076 12.9 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain TPP_enzyme_M PF00205.20 MSTRG.12451.1_2 - 0.17 11.5 0.0 0.38 10.4 0.0 1.6 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain Antimicrobial13 PF08108.9 MSTRG.16723.1_2 - 0.17 11.9 0.2 0.36 10.8 0.2 1.6 1 0 0 1 1 1 0 Halocidin family EPTP PF03736.15 MSTRG.27587.1_2 - 0.09 12.7 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 EPTP domain CPSF_A PF03178.13 MSTRG.25744.1_1 - 8.3e-92 307.8 0.0 6.1e-90 301.7 0.0 2.4 2 0 0 2 2 2 2 CPSF A subunit region MMS1_N PF10433.7 MSTRG.25744.1_1 - 2.2e-40 138.5 0.0 2.1e-25 89.2 0.0 3.0 2 1 1 3 3 3 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term UspB PF10625.7 MSTRG.25744.1_1 - 0.067 13.0 0.1 0.16 11.8 0.1 1.6 1 0 0 1 1 1 0 Universal stress protein B (UspB) PTPLA PF04387.12 MSTRG.25881.1_3 - 2.7e-27 95.4 0.9 3.9e-27 94.9 0.9 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA DUF2781 PF10914.6 MSTRG.25881.1_3 - 0.062 13.6 0.9 0.12 12.6 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2781) Abhydrolase_5 PF12695.5 MSTRG.14846.1_2 - 0.034 13.8 0.0 0.042 13.4 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 MSTRG.14846.1_2 - 0.16 11.1 0.3 1.2 8.2 0.3 2.0 1 1 0 1 1 1 0 Serine aminopeptidase, S33 COP23 PF14218.4 MSTRG.27977.6_2 - 0.008 15.8 5.1 0.29 10.7 0.6 2.3 2 0 0 2 2 2 2 Circadian oscillating protein COP23 DUF3827 PF12877.5 MSTRG.22182.1_2 - 1.3e-286 952.3 3.1 2e-286 951.7 3.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3827) SKG6 PF08693.8 MSTRG.22182.1_2 - 7.5 5.9 7.8 18 4.7 7.8 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain MAP7 PF05672.9 MSTRG.15099.1_2 - 5.1e-29 101.0 61.4 4.9e-19 68.5 34.4 4.7 3 2 1 4 4 4 3 MAP7 (E-MAP-115) family RhoGAP PF00620.25 MSTRG.22173.1_1 - 1.8e-44 151.1 0.0 3.4e-44 150.2 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain SH3_1 PF00018.26 MSTRG.22173.1_1 - 2.6e-10 39.6 0.0 4.4e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.22173.1_1 - 8.6e-10 38.2 0.0 1.4e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.22173.1_1 - 1.1e-08 34.5 0.0 2.2e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF1658 PF07871.9 MSTRG.22173.1_1 - 0.014 15.1 4.8 0.04 13.7 4.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1658) FlaC_arch PF05377.9 MSTRG.22173.1_1 - 7.1 7.0 5.6 0.81 10.0 0.6 2.0 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) SNAPc19 PF15497.4 MSTRG.10995.1_2 - 8.8e-20 70.8 9.9 8.8e-20 70.8 9.9 2.3 1 1 1 2 2 2 1 snRNA-activating protein complex subunit 19, SNAPc subunit 19 Mit_KHE1 PF10173.7 MSTRG.10995.1_2 - 0.039 13.9 1.6 0.056 13.4 1.6 1.1 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related Sigma70_ner PF04546.11 MSTRG.10995.1_2 - 0.18 11.6 13.6 0.26 11.0 13.6 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region BUD22 PF09073.8 MSTRG.10995.1_2 - 0.66 9.1 10.0 0.85 8.8 10.0 1.1 1 0 0 1 1 1 0 BUD22 DUF2722 PF10846.6 MSTRG.10995.1_2 - 4.9 5.9 6.1 6 5.6 6.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF3740 PF12548.6 MSTRG.10995.1_2 - 5.6 7.2 8.5 2.8 8.2 6.3 1.5 1 1 0 1 1 1 0 Sulfatase protein SDA1 PF05285.10 MSTRG.10995.1_2 - 6.8 5.9 15.0 8.1 5.7 15.0 1.1 1 0 0 1 1 1 0 SDA1 SGT1 PF07093.9 MSTRG.10995.1_2 - 7.8 4.7 11.0 10 4.3 11.0 1.1 1 0 0 1 1 1 0 SGT1 protein DUF1510 PF07423.9 MSTRG.10995.1_2 - 7.9 5.7 12.9 10 5.3 12.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CDC45 PF02724.12 MSTRG.10995.1_2 - 9.1 4.3 12.3 11 4.0 12.3 1.2 1 0 0 1 1 1 0 CDC45-like protein 7tm_2 PF00002.22 MSTRG.4259.1_2 - 3.6e-89 298.1 17.7 5.4e-89 297.6 17.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 MSTRG.4259.1_2 - 0.0048 17.0 0.6 0.016 15.4 0.0 2.1 2 0 0 2 2 2 1 Hormone receptor domain TRIC PF05197.11 MSTRG.2071.1_3 - 4.7e-80 267.5 0.6 6.8e-80 267.0 0.6 1.2 1 0 0 1 1 1 1 TRIC channel UPF0126 PF03458.11 MSTRG.2071.1_3 - 0.00059 19.7 1.3 1.2 9.1 0.1 2.7 2 0 0 2 2 2 2 UPF0126 domain zf-C2H2 PF00096.24 MSTRG.17180.1_3 - 2e-71 232.5 429.0 0.00069 19.8 3.2 48.4 49 0 0 49 49 49 38 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.17180.1_3 - 2.3e-51 167.8 429.5 0.0015 19.1 2.1 49.0 49 0 0 49 49 49 37 C2H2-type zinc finger zf-H2C2_2 PF13465.4 MSTRG.17180.1_3 - 1.4e-47 158.0 332.8 1.2e-05 25.4 1.4 44.1 43 2 0 43 43 43 23 Zinc-finger double domain zf-C2H2_jaz PF12171.6 MSTRG.17180.1_3 - 0.00031 20.9 234.4 0.019 15.1 0.1 36.0 39 1 1 40 40 40 17 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 MSTRG.17180.1_3 - 0.056 13.1 0.0 0.056 13.1 0.0 26.7 33 1 1 34 34 34 0 zinc-finger C2H2-type Coronavirus_5 PF05528.9 MSTRG.17180.1_3 - 3.3 7.6 14.0 2.3 8.1 0.3 5.7 5 0 0 5 5 5 0 Coronavirus gene 5 protein IL17_R_N PF15037.4 MSTRG.24655.3_3 - 1.2e-06 27.6 0.3 1.3e-06 27.5 0.3 1.1 1 0 0 1 1 1 1 Interleukin-17 receptor extracellular region G-gamma PF00631.20 MSTRG.29625.1_1 - 3e-07 30.2 0.0 4.2e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 GGL domain MHC_I PF00129.16 MSTRG.17773.1_3 - 9e-41 139.2 1.1 1.2e-40 138.8 1.1 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 MSTRG.17773.1_3 - 0.0045 17.3 0.0 0.0094 16.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Pkinase_Tyr PF07714.15 MSTRG.2825.2_3 - 8.4e-91 303.7 0.0 1.1e-90 303.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.2825.2_3 - 1.8e-43 148.7 0.0 2.7e-43 148.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 MSTRG.2825.2_3 - 1.2e-26 92.4 0.5 2.7e-26 91.3 0.5 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 MSTRG.2825.2_3 - 8.3e-19 66.8 1.0 2.1e-18 65.5 0.3 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 MSTRG.2825.2_3 - 4.4e-13 48.7 0.1 1.1e-12 47.5 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.2825.2_3 - 3.5e-10 39.3 0.0 9.5e-10 37.9 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 MSTRG.2825.2_3 - 0.066 13.4 0.1 0.12 12.5 0.1 1.4 1 0 0 1 1 1 0 Bacterial SH3 domain zf-H2C2_2 PF13465.4 MSTRG.20429.2_1 - 7.5e-31 105.0 65.5 8.3e-08 32.2 5.1 9.3 9 0 0 9 9 9 6 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.20429.2_1 - 8.4e-24 82.5 77.1 0.00013 22.1 5.0 9.2 9 0 0 9 9 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.20429.2_1 - 3.3e-12 46.0 82.9 0.0019 18.7 0.7 9.7 10 0 0 10 10 9 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.20429.2_1 - 1.3e-09 37.9 48.5 0.013 15.6 1.7 8.6 8 0 0 8 8 8 4 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 MSTRG.20429.2_1 - 1.2e-08 34.9 1.5 1.2e-08 34.9 1.5 4.4 4 0 0 4 4 3 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.4 MSTRG.20429.2_1 - 1.5e-07 31.1 62.5 0.029 14.2 1.4 8.8 8 0 0 8 8 8 7 C2H2-type zinc finger Homeobox PF00046.27 MSTRG.20429.2_1 - 7.9e-06 25.5 0.1 5.1e-05 22.9 0.0 2.4 2 0 0 2 2 2 1 Homeobox domain zf-H2C2_5 PF13909.4 MSTRG.20429.2_1 - 0.00036 20.1 0.2 0.00036 20.1 0.2 5.6 5 1 0 5 5 3 2 C2H2-type zinc-finger domain zf-met PF12874.5 MSTRG.20429.2_1 - 0.00047 20.3 60.5 0.18 12.1 3.5 8.5 9 0 0 9 9 9 4 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.3 MSTRG.20429.2_1 - 2.4 8.8 29.4 0.4 11.3 1.6 5.6 4 1 1 5 5 5 0 zinc-ribbon family zf-C2H2_11 PF16622.3 MSTRG.20429.2_1 - 7.6 6.3 33.2 0.12 12.0 0.5 7.1 7 0 0 7 7 7 0 zinc-finger C2H2-type DZR PF12773.5 MSTRG.20429.2_1 - 7.8 6.5 26.1 0.1 12.5 0.8 5.1 4 1 0 4 4 4 0 Double zinc ribbon zf-DHHC PF01529.18 MSTRG.7351.1_2 - 1.3e-34 119.1 16.2 1.3e-34 119.1 16.2 3.1 3 0 0 3 3 3 1 DHHC palmitoyltransferase RasGAP PF00616.17 MSTRG.5922.2_3 - 1.6e-58 197.7 0.1 4.7e-58 196.2 0.1 1.9 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.13 MSTRG.5922.2_3 - 2.6e-35 121.3 9.5 2.6e-35 121.3 9.5 3.3 2 1 0 2 2 2 1 RasGAP C-terminus IQ PF00612.25 MSTRG.5922.2_3 - 4.8e-19 66.2 17.5 0.00015 21.1 0.0 5.4 5 0 0 5 5 5 4 IQ calmodulin-binding motif CH PF00307.29 MSTRG.5922.2_3 - 8.1e-18 64.5 1.5 4.9e-17 62.0 0.0 3.4 3 0 0 3 3 3 1 Calponin homology (CH) domain WW PF00397.24 MSTRG.5922.2_3 - 0.0012 18.6 5.4 0.0023 17.7 5.4 1.5 1 0 0 1 1 1 1 WW domain bZIP_1 PF00170.19 MSTRG.5922.2_3 - 0.45 10.5 8.2 0.098 12.6 1.4 3.4 3 0 0 3 3 3 0 bZIP transcription factor SecB PF02556.12 MSTRG.4317.1_2 - 0.078 12.7 0.1 0.11 12.3 0.1 1.1 1 0 0 1 1 1 0 Preprotein translocase subunit SecB 6PGD PF00393.17 MSTRG.18255.1_2 - 4.4e-129 429.8 0.0 5.8e-129 429.4 0.0 1.2 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.13 MSTRG.18255.1_2 - 3.2e-49 167.0 0.0 4.6e-49 166.5 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.4 MSTRG.18255.1_2 - 0.0021 18.2 0.0 0.0062 16.7 0.0 1.8 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.15 MSTRG.18255.1_2 - 0.048 14.1 0.1 0.095 13.2 0.1 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent CoatB PF10389.7 MSTRG.18255.1_2 - 0.24 11.1 0.8 5.2 6.9 0.0 2.3 2 0 0 2 2 2 0 Bacteriophage coat protein B Sas10_Utp3 PF04000.13 MSTRG.18315.4_1 - 7.7e-17 61.5 0.1 1.1e-16 61.1 0.1 1.2 1 0 0 1 1 1 1 Sas10/Utp3/C1D family DUF932 PF06067.9 MSTRG.18315.4_1 - 0.045 13.4 0.2 0.075 12.7 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF932) DUF842 PF05811.11 MSTRG.4646.1_2 - 1.1e-43 148.1 14.1 1.4e-43 147.7 14.1 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF842) MFS_1 PF07690.14 MSTRG.26123.2_1 - 7.9e-13 47.9 13.5 1.5e-12 47.0 13.5 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.22 MSTRG.26123.2_1 - 3.8e-09 35.8 4.1 3.8e-09 35.8 4.1 1.4 2 0 0 2 2 2 1 Sugar (and other) transporter Sugar_tr PF00083.22 MSTRG.26123.2_2 - 1.2e-18 67.1 2.0 1.7e-18 66.6 2.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 MSTRG.26123.2_2 - 7e-10 38.2 0.3 1.1e-09 37.5 0.3 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Ribosomal_S8 PF00410.17 MSTRG.19024.1_3 - 9.1e-22 77.2 0.0 1.4e-21 76.6 0.0 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 RhoGEF PF00621.18 MSTRG.12960.3_3 - 0.00021 21.5 0.0 0.0003 20.9 0.0 1.2 1 0 0 1 1 1 1 RhoGEF domain CDC27 PF09507.8 MSTRG.12960.3_3 - 0.039 13.2 1.7 0.058 12.6 1.7 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 PRIMA1 PF16101.3 MSTRG.12960.3_3 - 0.051 13.5 6.2 0.098 12.6 6.2 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Mito_fiss_reg PF05308.9 MSTRG.12960.3_3 - 0.14 12.0 6.0 0.22 11.4 6.0 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator Pap_E4 PF02711.12 MSTRG.12960.3_3 - 5 8.1 10.4 1.3 9.9 6.7 1.9 2 0 0 2 2 2 0 E4 protein Peptidase_M24 PF00557.22 MSTRG.5421.1_1 - 2.7e-54 183.9 0.1 6.5e-54 182.7 0.2 1.6 2 0 0 2 2 2 1 Metallopeptidase family M24 AMP_N PF05195.14 MSTRG.5421.1_1 - 5.3e-28 97.1 0.0 1.2e-27 96.0 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain KASH PF10541.7 MSTRG.18311.1_1 - 0.038 14.1 7.9 0.18 11.9 1.3 2.5 2 0 0 2 2 2 0 Nuclear envelope localisation domain TMEM52 PF14979.4 MSTRG.18311.1_1 - 1.2 8.9 6.8 0.17 11.7 1.4 2.2 2 0 0 2 2 2 0 Transmembrane 52 Ank_2 PF12796.5 MSTRG.6807.1_1 - 9.2e-26 90.1 12.2 2e-14 53.8 0.6 4.1 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.6807.1_1 - 4.2e-24 84.5 5.0 8.7e-08 32.4 0.1 5.4 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.6807.1_1 - 5.1e-19 67.7 17.7 3.1e-06 27.2 0.3 6.5 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.4 MSTRG.6807.1_1 - 5.7e-16 56.9 8.0 0.0065 16.7 0.0 7.5 6 1 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.4 MSTRG.6807.1_1 - 2.6e-15 56.1 9.9 6.9e-05 23.0 0.5 4.5 3 1 2 5 5 5 4 Ankyrin repeats (many copies) SOCS_box PF07525.14 MSTRG.6807.1_1 - 2.7e-09 37.1 0.9 7.9e-09 35.6 0.9 1.9 1 0 0 1 1 1 1 SOCS box Vps8 PF12816.5 MSTRG.6807.1_1 - 0.056 12.8 0.2 0.1 12.0 0.2 1.3 1 0 0 1 1 1 0 Golgi CORVET complex core vacuolar protein 8 Pkinase PF00069.23 MSTRG.29780.1_2 - 1.2e-41 142.7 0.0 1.6e-41 142.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.29780.1_2 - 2.6e-21 76.0 0.0 3.1e-21 75.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.29780.1_2 - 0.0014 17.9 0.0 0.0015 17.7 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.21 MSTRG.29780.1_2 - 0.036 13.8 0.0 0.048 13.4 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.9 MSTRG.29780.1_2 - 0.037 12.9 0.1 0.053 12.3 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.12 MSTRG.29780.1_2 - 0.062 12.5 0.0 0.085 12.1 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SAYSvFN PF10260.7 MSTRG.26078.1_2 - 0.071 12.9 0.1 0.12 12.2 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized conserved domain (SAYSvFN) Hist_deacetyl PF00850.17 MSTRG.12373.1_2 - 1.1e-81 274.6 0.1 1.9e-81 273.8 0.1 1.4 1 0 0 1 1 1 1 Histone deacetylase domain Presenilin PF01080.15 MSTRG.12373.1_2 - 0.12 11.0 0.9 0.15 10.6 0.9 1.1 1 0 0 1 1 1 0 Presenilin RNA_polI_A34 PF08208.9 MSTRG.12373.1_2 - 3.4 7.6 18.7 5.8 6.8 18.7 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Pkinase PF00069.23 MSTRG.12480.1_2 - 1.1e-61 208.4 0.0 1.8e-61 207.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain CNH PF00780.20 MSTRG.12480.1_2 - 2.1e-58 198.0 0.0 3.1e-58 197.4 0.0 1.3 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.15 MSTRG.12480.1_2 - 7.5e-46 156.4 0.0 1.2e-45 155.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.12480.1_2 - 0.0069 15.6 0.0 0.0069 15.6 0.0 2.2 3 0 0 3 3 3 1 Kinase-like wnt PF00110.17 MSTRG.23032.1_3 - 2.4e-123 411.4 16.8 4.4e-123 410.5 16.8 1.4 1 0 0 1 1 1 1 wnt family APG5 PF04106.10 MSTRG.3565.1_3 - 3.8e-43 147.4 0.1 5e-43 147.0 0.1 1.2 1 0 0 1 1 1 1 Autophagy protein Apg5 PMP22_Claudin PF00822.18 MSTRG.27118.1_1 - 2.8e-37 128.0 16.0 4.6e-37 127.3 16.0 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 MSTRG.27118.1_1 - 1.3e-08 34.7 17.4 9.4e-08 31.9 17.4 2.1 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction TMEM37 PF15108.4 MSTRG.27118.1_1 - 0.00077 19.3 8.5 0.0015 18.3 8.5 1.4 1 0 0 1 1 1 1 Voltage-dependent calcium channel gamma-like subunit protein family DUF418 PF04235.10 MSTRG.27118.1_1 - 0.01 15.6 0.3 0.01 15.6 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF418) Motile_Sperm PF00635.24 MSTRG.15633.1_1 - 3.7e-32 110.3 0.2 6e-32 109.6 0.2 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain bZIP_1 PF00170.19 MSTRG.15633.1_1 - 0.019 14.9 3.0 0.042 13.8 3.0 1.6 1 0 0 1 1 1 0 bZIP transcription factor DUF972 PF06156.11 MSTRG.15633.1_1 - 0.028 14.9 0.1 0.083 13.4 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF972) ASH PF15780.3 MSTRG.15633.1_1 - 0.074 13.1 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Atrophin-1 PF03154.13 MSTRG.15633.1_1 - 0.077 11.1 13.6 0.016 13.4 3.4 2.1 2 0 0 2 2 2 0 Atrophin-1 family DivIC PF04977.13 MSTRG.15633.1_1 - 0.19 11.4 0.1 0.39 10.4 0.1 1.4 1 0 0 1 1 1 0 Septum formation initiator GIT_CC PF16559.3 MSTRG.15633.1_1 - 0.21 11.5 1.1 0.45 10.5 1.1 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF3915 PF13054.4 MSTRG.15633.1_1 - 1 9.2 6.5 2 8.3 6.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF202 PF02656.13 MSTRG.15633.1_1 - 1.2 9.5 6.2 0.5 10.7 0.9 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF202) EMP24_GP25L PF01105.22 MSTRG.15633.1_1 - 3.3 7.5 6.0 0.28 11.0 0.6 2.1 2 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF3915 PF13054.4 MSTRG.15633.1_2 - 1.3 8.9 2.8 2.2 8.1 2.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF3915 PF13054.4 MSTRG.15633.1_3 - 4.3 7.2 5.3 9.5 6.1 5.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) NOT2_3_5 PF04153.16 MSTRG.6869.6_2 - 2.1e-38 131.3 11.0 3.1e-38 130.7 11.0 1.3 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family Na_sulph_symp PF00939.17 MSTRG.4477.1_2 - 2.9e-102 343.0 23.2 3.7e-102 342.7 23.2 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.14 MSTRG.4477.1_2 - 1.5e-40 139.2 46.6 2.8e-20 72.6 6.3 3.2 2 1 1 3 3 3 3 Citrate transporter FCH PF00611.21 MSTRG.5891.1_1 - 3.7e-15 55.8 0.4 3.7e-15 55.8 0.4 2.0 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.4 MSTRG.5891.1_1 - 9.2e-15 54.1 0.2 1.9e-14 53.1 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.5891.1_1 - 5.3e-14 51.4 2.6 2e-13 49.5 0.0 2.7 3 0 0 3 3 3 1 SH3 domain SH3_2 PF07653.15 MSTRG.5891.1_1 - 4.5e-07 29.3 0.0 9.1e-07 28.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF641 PF04859.10 MSTRG.5891.1_1 - 0.0034 17.6 3.5 0.0034 17.6 3.5 1.6 2 0 0 2 2 2 1 Plant protein of unknown function (DUF641) BAR PF03114.16 MSTRG.5891.1_1 - 3.5 7.1 14.7 33 3.9 14.7 2.4 1 1 0 1 1 1 0 BAR domain DUF4407 PF14362.4 MSTRG.5891.1_1 - 6.6 5.9 7.6 11 5.1 7.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.13 MSTRG.5891.1_1 - 9.7 5.5 6.5 14 5.0 6.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Helicase_C PF00271.29 MSTRG.20304.5_3 - 7.9e-19 67.9 0.0 1.3e-18 67.2 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain 7tm_1 PF00001.19 MSTRG.28117.3_2 - 2.6e-39 135.0 21.5 2.6e-39 135.0 21.5 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 MSTRG.28117.3_2 - 4e-05 22.9 13.3 0.00011 21.4 12.8 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw CAP_N PF01213.17 MSTRG.21629.2_2 - 1.5 8.1 13.5 1.7 7.9 13.5 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.3 MSTRG.21629.2_2 - 4 7.4 14.1 8.6 6.3 14.1 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Mito_fiss_reg PF05308.9 MSTRG.21629.2_2 - 7.8 6.4 13.1 15 5.4 13.1 1.5 1 0 0 1 1 1 0 Mitochondrial fission regulator ETF PF01012.19 MSTRG.11070.1_2 - 3.7e-42 144.1 4.1 5.3e-42 143.6 4.1 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.17 MSTRG.11070.1_2 - 8.9e-38 128.1 0.3 1.8e-37 127.1 0.3 1.6 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain DMA PF03474.12 MSTRG.11070.1_2 - 0.0088 15.5 0.1 0.016 14.6 0.1 1.4 1 0 0 1 1 1 1 DMRTA motif DUF2103 PF09876.7 MSTRG.11070.1_2 - 0.14 12.0 0.0 0.34 10.8 0.0 1.6 1 0 0 1 1 1 0 Predicted metal-binding protein (DUF2103) NR_Repeat PF14046.4 MSTRG.16543.1_2 - 0.045 13.8 0.3 0.094 12.7 0.3 1.5 1 0 0 1 1 1 0 Nuclear receptor repeat Nup88 PF10168.7 MSTRG.16543.1_2 - 0.051 11.2 21.4 0.079 10.6 21.4 1.3 1 0 0 1 1 1 0 Nuclear pore component ING PF12998.5 MSTRG.16543.1_2 - 0.06 13.8 21.2 0.03 14.7 9.9 2.7 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Prefoldin_2 PF01920.18 MSTRG.16543.1_2 - 0.06 13.2 0.9 0.06 13.2 0.9 5.1 1 1 3 5 5 5 0 Prefoldin subunit Phage_GP20 PF06810.9 MSTRG.16543.1_2 - 0.22 11.2 17.7 0.24 11.1 4.8 3.1 1 1 2 3 3 3 0 Phage minor structural protein GP20 IFT57 PF10498.7 MSTRG.16543.1_2 - 0.27 10.0 30.2 0.5 9.2 14.9 2.4 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 ATG16 PF08614.9 MSTRG.16543.1_2 - 0.61 10.1 51.2 0.029 14.4 22.2 4.0 1 1 1 3 3 3 0 Autophagy protein 16 (ATG16) LpxB PF02684.13 MSTRG.16543.1_2 - 2 7.0 11.1 0.59 8.8 0.5 2.2 2 0 0 2 2 2 0 Lipid-A-disaccharide synthetase KLRAQ PF10205.7 MSTRG.16543.1_2 - 2.9 8.1 30.3 0.66 10.1 10.0 3.8 1 1 2 3 3 3 0 Predicted coiled-coil domain-containing protein CCDC144C PF14915.4 MSTRG.16543.1_2 - 3.5 6.5 43.6 13 4.6 43.5 2.0 1 1 0 1 1 1 0 CCDC144C protein coiled-coil region CALCOCO1 PF07888.9 MSTRG.16543.1_2 - 4.5 5.6 45.5 2.1e+02 0.1 45.5 2.2 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Leu_zip PF15294.4 MSTRG.16543.1_2 - 4.9 6.4 32.6 4.9 6.4 6.8 2.5 1 1 1 2 2 2 0 Leucine zipper Fib_alpha PF08702.8 MSTRG.16543.1_2 - 5.1 7.2 23.9 0.5 10.4 9.5 3.3 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family bZIP_1 PF00170.19 MSTRG.16543.1_2 - 6.7 6.8 23.7 0.23 11.4 3.2 5.3 3 3 2 5 5 5 0 bZIP transcription factor DUF3584 PF12128.6 MSTRG.16543.1_2 - 6.9 3.9 35.2 0.035 11.5 11.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) DUF4407 PF14362.4 MSTRG.16543.1_2 - 7.7 5.6 21.4 6.5 5.9 11.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Reo_sigmaC PF04582.10 MSTRG.16543.1_2 - 7.9 5.6 16.1 1.5 8.0 5.1 2.4 1 1 1 2 2 2 0 Reovirus sigma C capsid protein TRAPP PF04051.14 MSTRG.21768.2_3 - 3e-36 124.2 0.1 4.1e-36 123.7 0.1 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component TRAPPC9-Trs120 PF08626.9 MSTRG.11248.2_1 - 2.4e-46 157.6 0.0 8.1e-18 63.1 0.0 6.9 2 2 2 4 4 4 4 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Vps23_core PF09454.8 MSTRG.11248.2_1 - 0.067 13.0 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Vps23 core domain TPR_1 PF00515.26 MSTRG.11248.2_1 - 0.16 11.7 2.7 1.2 8.9 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat ABC_tran PF00005.25 MSTRG.10609.1_3 - 1.8e-31 109.4 0.0 2.4e-31 109.0 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.4 MSTRG.10609.1_3 - 4.7e-08 33.1 0.4 0.00043 20.1 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.5 MSTRG.10609.1_3 - 6.4e-05 22.1 14.2 8.9e-05 21.6 14.2 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.5 MSTRG.10609.1_3 - 0.0026 16.9 6.3 0.0038 16.4 6.3 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_23 PF13476.4 MSTRG.10609.1_3 - 0.0057 17.1 0.4 0.0082 16.5 0.4 1.2 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.4 MSTRG.10609.1_3 - 0.007 15.9 0.2 0.013 15.0 0.2 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.4 MSTRG.10609.1_3 - 0.11 11.9 0.0 0.14 11.6 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain DUF258 PF03193.14 MSTRG.10609.1_3 - 0.12 12.2 0.1 0.22 11.3 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function, DUF258 SRP54 PF00448.20 MSTRG.10609.1_3 - 0.12 11.9 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain DUF1673 PF07895.9 MSTRG.10609.1_3 - 0.27 10.8 3.7 29 4.1 4.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1673) KH_1 PF00013.27 MSTRG.20975.12_1 - 5.8e-49 163.7 16.2 8.8e-19 67.0 0.9 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.15 MSTRG.20975.12_1 - 5.4e-14 51.6 8.5 8.7e-05 22.1 0.1 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.4 MSTRG.20975.12_1 - 1.4e-06 28.0 4.4 0.15 11.9 0.4 3.4 3 0 0 3 3 3 3 KH domain KH_5 PF13184.4 MSTRG.20975.12_1 - 0.00072 19.5 8.0 1.2 9.1 0.1 3.4 3 0 0 3 3 3 3 NusA-like KH domain MOEP19 PF16005.3 MSTRG.20975.12_1 - 0.011 15.6 0.0 0.11 12.4 0.0 2.5 3 0 0 3 3 3 0 KH-like RNA-binding domain CaATP_NAI PF12515.6 MSTRG.5894.1_2 - 0.013 14.9 1.9 3.6 7.1 0.0 2.6 2 0 0 2 2 2 0 Ca2+-ATPase N terminal autoinhibitory domain LRR_4 PF12799.5 MSTRG.20927.1_3 - 7.1 7.1 14.8 16 5.9 2.4 4.7 3 2 1 4 4 4 0 Leucine Rich repeats (2 copies) Gln-synt_C PF00120.22 MSTRG.13147.1_1 - 9.6e-07 28.0 0.0 5.8e-06 25.4 0.0 1.8 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain VD10_N PF08476.8 MSTRG.13147.1_1 - 0.066 12.8 0.0 0.15 11.6 0.0 1.6 1 0 0 1 1 1 0 Viral D10 N-terminal CEP170_C PF15308.4 MSTRG.16414.2_2 - 3.3e-31 108.5 0.1 4.1e-31 108.1 0.1 1.1 1 0 0 1 1 1 1 CEP170 C-terminus Pkinase PF00069.23 MSTRG.21773.2_2 - 2.6e-61 207.2 0.0 6.8e-61 205.8 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain HR1 PF02185.14 MSTRG.21773.2_2 - 2.8e-50 168.1 28.4 7.8e-18 64.2 7.0 3.5 3 0 0 3 3 3 3 Hr1 repeat Pkinase_Tyr PF07714.15 MSTRG.21773.2_2 - 1.8e-37 128.9 0.0 2.8e-37 128.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.22 MSTRG.21773.2_2 - 1.9e-09 37.9 0.6 5.3e-09 36.5 0.6 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 MSTRG.21773.2_2 - 9.7e-06 25.0 0.0 2e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Uds1 PF15456.4 MSTRG.21773.2_2 - 0.00073 19.6 17.1 0.026 14.5 2.4 3.3 3 0 0 3 3 3 2 Up-regulated During Septation Cut12 PF11500.6 MSTRG.21773.2_2 - 0.053 13.4 1.0 0.14 12.0 1.0 1.6 1 0 0 1 1 1 0 Spindle pole body formation-associated protein GRAM PF02893.18 MSTRG.7979.1_2 - 1.6e-11 43.9 0.0 2.5e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 GRAM domain VWD PF00094.23 MSTRG.13446.1_2 - 1.7e-74 249.2 4.0 7.9e-37 126.8 0.2 2.8 3 0 0 3 3 3 2 von Willebrand factor type D domain C8 PF08742.9 MSTRG.13446.1_2 - 5.6e-20 71.4 2.1 5.6e-20 71.4 2.1 3.6 4 1 0 4 4 4 1 C8 domain TIL PF01826.15 MSTRG.13446.1_2 - 1.5e-12 47.4 17.7 1.5e-12 47.4 17.7 5.4 5 0 0 5 5 5 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.5 MSTRG.13446.1_2 - 5.3e-09 35.8 15.3 5.3e-09 35.8 15.3 4.2 3 1 1 4 4 4 1 TILa domain Collectrin PF16959.3 MSTRG.13446.1_2 - 0.0089 15.6 0.0 1.3 8.5 0.0 2.2 2 0 0 2 2 2 2 Renal amino acid transporter Agenet PF05641.10 MSTRG.1747.6_2 - 2e-06 28.1 0.0 2.8e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Agenet domain Pkinase_Tyr PF07714.15 MSTRG.21071.1_1 - 1.8e-60 204.3 0.0 2.5e-60 203.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.21071.1_1 - 4.7e-56 189.9 0.0 8.4e-56 189.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.21 MSTRG.21071.1_1 - 0.0016 18.3 0.0 0.0028 17.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Occludin_ELL PF07303.11 MSTRG.21071.1_1 - 0.73 10.4 3.5 1.5 9.4 3.5 1.5 1 0 0 1 1 1 0 Occludin homology domain CENP-H PF05837.10 MSTRG.21071.1_1 - 0.78 10.0 4.0 2.1 8.7 4.0 1.6 1 0 0 1 1 1 0 Centromere protein H (CENP-H) RBP_receptor PF14752.4 MSTRG.11471.1_3 - 3e-198 660.1 21.7 3.5e-198 659.9 21.7 1.0 1 0 0 1 1 1 1 Retinol binding protein receptor LIM PF00412.20 MSTRG.7385.2_1 - 2.3e-06 27.6 8.4 4.6e-06 26.6 8.4 1.6 1 0 0 1 1 1 1 LIM domain Med27 PF11571.6 MSTRG.7385.2_1 - 0.0012 19.0 0.9 0.0036 17.5 0.9 1.8 1 0 0 1 1 1 1 Mediator complex subunit 27 PX PF00787.22 MSTRG.19332.1_1 - 1.8e-17 63.2 0.1 3.8e-17 62.2 0.1 1.5 1 0 0 1 1 1 1 PX domain Kinesin_assoc PF16183.3 MSTRG.19332.1_1 - 2.1e-10 40.9 2.9 0.00035 20.7 0.3 2.4 1 1 1 2 2 2 2 Kinesin-associated FHA PF00498.24 MSTRG.19332.1_1 - 3.9e-05 23.8 0.0 7.5e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.3 MSTRG.19332.1_1 - 0.00037 20.6 0.0 0.00073 19.7 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain MerE PF05052.10 MSTRG.19332.1_1 - 0.14 12.0 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 MerE protein DUF3371 PF11851.6 MSTRG.1612.1_3 - 2.4e-29 102.8 3.1 2.4e-29 102.8 3.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3371) HLH PF00010.24 MSTRG.1612.1_3 - 2.8e-15 55.9 0.4 5.2e-15 55.0 0.4 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain MITF_TFEB_C_3_N PF15951.3 MSTRG.1612.1_3 - 2.5e-08 34.5 0.1 2.5e-08 34.5 0.1 2.2 2 1 0 2 2 2 1 MITF/TFEB/TFEC/TFE3 N-terminus CDC37_N PF03234.12 MSTRG.1612.1_3 - 2.2 9.1 5.4 0.54 11.1 1.2 2.0 1 1 1 2 2 2 0 Cdc37 N terminal kinase binding Oxysterol_BP PF01237.16 MSTRG.20394.3_3 - 1.4e-81 274.0 6.1 1e-79 267.9 6.1 2.2 1 1 0 1 1 1 1 Oxysterol-binding protein PH PF00169.27 MSTRG.20394.3_3 - 1.2e-11 44.9 0.1 3.5e-11 43.4 0.0 1.9 2 0 0 2 2 2 1 PH domain PH_8 PF15409.4 MSTRG.20394.3_3 - 2.2e-08 34.1 0.0 5.1e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.4 MSTRG.20394.3_3 - 3.1e-05 24.1 0.0 0.00012 22.2 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.4 MSTRG.20394.3_3 - 0.033 14.4 0.1 0.11 12.7 0.0 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain PH_13 PF16652.3 MSTRG.20394.3_3 - 0.051 13.3 0.1 0.16 11.7 0.0 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain PH_11 PF15413.4 MSTRG.20394.3_3 - 0.11 12.7 1.4 3.5 7.9 0.2 3.3 2 1 0 2 2 2 0 Pleckstrin homology domain Pax2_C PF12403.6 MSTRG.11380.1_1 - 0.0018 18.2 4.4 0.0059 16.6 4.4 1.8 1 1 1 2 2 2 1 Paired-box protein 2 C terminal PDZ PF00595.22 MSTRG.18643.1_3 - 3.1e-16 59.3 0.1 5.1e-16 58.7 0.1 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.18643.1_3 - 1.5e-06 28.3 0.0 2.7e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Nha1_C PF08619.8 MSTRG.18643.1_3 - 0.069 12.2 0.0 0.08 12.0 0.0 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus DPM3 PF08285.9 MSTRG.18643.1_3 - 0.17 11.9 0.0 0.3 11.1 0.0 1.3 1 0 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) SSF PF00474.15 MSTRG.19191.1_2 - 4.8e-30 104.6 24.6 4.8e-30 104.6 24.6 1.5 2 0 0 2 2 2 1 Sodium:solute symporter family Sec7 PF01369.18 MSTRG.14558.2_3 - 5.6e-62 208.6 1.0 9.8e-62 207.8 1.0 1.4 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.5 MSTRG.14558.2_3 - 4.3e-27 94.9 9.3 4.3e-27 94.9 9.3 3.1 2 1 1 3 3 3 2 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF758 PF05527.9 MSTRG.14558.2_3 - 0.0014 18.6 0.1 0.0046 16.8 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF758) DUF1045 PF06299.10 MSTRG.14558.2_3 - 0.015 15.2 0.1 0.077 12.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1045) RRM_1 PF00076.20 MSTRG.594.2_1 - 7.5e-14 51.2 0.0 1.2e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) COX16 PF14138.4 MSTRG.8896.1_1 - 1.9e-23 82.6 0.2 3.1e-23 82.0 0.2 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 GTP_EFTU PF00009.25 MSTRG.23394.1_2 - 1.6e-46 158.2 0.0 2.5e-46 157.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.15 MSTRG.23394.1_2 - 3.9e-25 88.2 0.0 8.6e-25 87.1 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain HBS1_N PF08938.8 MSTRG.23394.1_2 - 2.6e-16 59.5 0.1 5.4e-16 58.5 0.1 1.5 1 0 0 1 1 1 1 HBS1 N-terminus GTP_EFTU_D2 PF03144.23 MSTRG.23394.1_2 - 1.6e-06 28.3 0.0 3.2e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 MSTRG.23394.1_2 - 1.4e-05 25.0 0.1 0.00039 20.4 0.1 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.4 MSTRG.23394.1_2 - 0.0044 17.2 0.0 0.0094 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain GTP_EFTU_D4 PF14578.4 MSTRG.23394.1_2 - 0.06 13.2 0.0 0.31 10.9 0.0 2.1 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Toxin_15 PF07906.11 MSTRG.23394.1_2 - 0.11 11.9 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 ShET2 enterotoxin, N-terminal region cobW PF02492.17 MSTRG.23394.1_2 - 0.12 11.8 0.2 12 5.3 0.0 2.9 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain Macoilin PF09726.7 MSTRG.25587.1_3 - 1.2e-76 258.6 20.9 1.4e-76 258.4 20.9 1.0 1 0 0 1 1 1 1 Transmembrane protein Trimer_CC PF08954.9 MSTRG.25587.1_3 - 0.0065 15.9 0.6 0.0065 15.9 0.6 2.8 2 0 0 2 2 2 1 Trimerisation motif TolA_bind_tri PF16331.3 MSTRG.25587.1_3 - 0.02 14.9 3.9 0.02 14.9 3.9 4.1 3 2 3 6 6 6 0 TolA binding protein trimerisation BRE1 PF08647.9 MSTRG.25587.1_3 - 0.021 14.8 24.5 0.27 11.2 3.9 4.3 3 1 1 4 4 4 0 BRE1 E3 ubiquitin ligase IncA PF04156.12 MSTRG.25587.1_3 - 0.054 13.1 35.9 1.2 8.7 10.8 3.1 1 1 2 3 3 3 0 IncA protein Reo_sigmaC PF04582.10 MSTRG.25587.1_3 - 0.083 12.1 9.3 0.95 8.7 0.9 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein TraI_2_C PF07515.9 MSTRG.25587.1_3 - 0.14 12.0 1.2 0.23 11.3 0.2 1.8 2 0 0 2 2 2 0 Putative conjugal transfer nickase/helicase TraI C-term TMF_TATA_bd PF12325.6 MSTRG.25587.1_3 - 0.74 9.9 28.6 0.27 11.3 4.6 3.2 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding ADIP PF11559.6 MSTRG.25587.1_3 - 0.85 9.6 30.9 1.2 9.0 3.4 3.2 1 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding DUF2524 PF10732.7 MSTRG.25587.1_3 - 1 9.6 10.2 1.3 9.2 1.9 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2524) IFP_35_N PF07334.11 MSTRG.25587.1_3 - 2.1 8.3 15.5 0.8 9.7 1.8 3.0 3 0 0 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus KASH_CCD PF14662.4 MSTRG.25587.1_3 - 3.9 7.1 30.9 0.072 12.8 1.8 3.1 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH MOLO1 PF17175.2 MSTRG.8070.1_2 - 2.2 8.3 5.8 2.6 8.0 0.8 2.4 2 0 0 2 2 2 0 Modulator of levamisole receptor-1 EzrA PF06160.10 MSTRG.3122.2_3 - 0.00085 17.5 38.2 0.0013 16.9 13.1 3.1 1 1 0 3 3 3 3 Septation ring formation regulator, EzrA TPR_MLP1_2 PF07926.10 MSTRG.3122.2_3 - 0.0018 18.2 58.5 0.034 14.1 21.2 4.0 2 1 1 4 4 4 3 TPR/MLP1/MLP2-like protein Laminin_II PF06009.10 MSTRG.3122.2_3 - 0.0068 16.3 39.5 0.74 9.7 4.8 4.3 3 2 1 4 4 4 4 Laminin Domain II GARP PF16731.3 MSTRG.3122.2_3 - 0.041 13.4 54.5 0.014 14.9 10.4 3.4 2 1 1 3 3 3 0 Glutamic acid/alanine-rich protein of Trypanosoma Alanine_zipper PF11839.6 MSTRG.3122.2_3 - 0.058 13.5 65.2 0.58 10.3 6.1 5.3 2 2 2 4 4 4 0 Alanine-zipper, major outer membrane lipoprotein DUF812 PF05667.9 MSTRG.3122.2_3 - 0.089 11.5 39.6 0.35 9.6 39.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF812) DUF948 PF06103.9 MSTRG.3122.2_3 - 0.12 12.5 31.7 2.8 8.1 1.3 5.7 3 3 2 5 5 5 0 Bacterial protein of unknown function (DUF948) DUF412 PF04217.11 MSTRG.3122.2_3 - 0.2 11.4 2.0 0.52 10.1 2.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF412 DUF745 PF05335.11 MSTRG.3122.2_3 - 0.32 10.6 54.1 0.21 11.2 18.8 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF745) Mod_r PF07200.11 MSTRG.3122.2_3 - 0.88 9.5 36.2 0.21 11.5 3.5 3.4 2 1 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Med30 PF11315.6 MSTRG.3122.2_3 - 1.9 8.6 23.7 0.41 10.7 1.2 3.3 2 1 1 3 3 3 0 Mediator complex subunit 30 Laminin_I PF06008.12 MSTRG.3122.2_3 - 2.7 7.5 49.7 9.5 5.7 16.3 3.9 1 1 1 2 2 2 0 Laminin Domain I Uso1_p115_C PF04871.11 MSTRG.3122.2_3 - 3.8 7.8 49.9 0.74 10.1 6.3 4.6 3 1 1 4 4 4 0 Uso1 / p115 like vesicle tethering protein, C terminal region TMPIT PF07851.11 MSTRG.3122.2_3 - 4.8 6.2 27.9 1 8.4 2.2 3.2 2 1 1 3 3 3 0 TMPIT-like protein APG6 PF04111.10 MSTRG.3122.2_3 - 5.2 6.2 42.9 2.4 7.3 14.2 3.1 2 1 1 3 3 3 0 Autophagy protein Apg6 DUF883 PF05957.11 MSTRG.3122.2_3 - 5.4 7.5 43.9 0.096 13.1 4.5 5.0 3 3 2 5 5 5 0 Bacterial protein of unknown function (DUF883) Reo_sigmaC PF04582.10 MSTRG.3122.2_3 - 8.3 5.6 16.1 4.8 6.4 6.8 3.4 1 1 3 4 4 4 0 Reovirus sigma C capsid protein Ig_3 PF13927.4 MSTRG.11776.1_3 - 2.5e-14 53.5 0.0 3.8e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 MSTRG.11776.1_3 - 1.4e-10 41.0 0.0 2.3e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.11776.1_3 - 5.4e-10 39.4 0.1 8.4e-10 38.7 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 MSTRG.11776.1_3 - 4.1e-06 26.7 0.0 7.1e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 MSTRG.11776.1_3 - 0.084 12.8 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain MIR PF02815.17 MSTRG.258.1_2 - 3.4e-15 56.2 0.2 1.2e-11 44.7 0.1 2.1 1 1 1 2 2 2 2 MIR domain Ig_3 PF13927.4 MSTRG.22939.1_3 - 1.7e-06 28.4 0.4 0.021 15.3 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 MSTRG.22939.1_3 - 9e-06 25.7 0.1 1.4e-05 25.0 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 MSTRG.22939.1_3 - 0.00011 22.1 0.9 0.0074 16.3 0.2 2.9 2 1 1 3 3 3 1 Immunoglobulin domain C2-set_2 PF08205.10 MSTRG.22939.1_3 - 0.00017 21.5 0.1 0.00034 20.5 0.1 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain I-set PF07679.14 MSTRG.22939.1_3 - 0.00036 20.4 0.1 0.008 16.1 0.0 2.5 2 1 0 2 2 2 1 Immunoglobulin I-set domain LRR19-TM PF15176.4 MSTRG.22939.1_3 - 0.035 14.0 0.0 0.072 12.9 0.0 1.5 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain SKG6 PF08693.8 MSTRG.22939.1_3 - 3.1 7.1 4.7 0.65 9.3 0.8 1.8 2 0 0 2 2 2 0 Transmembrane alpha-helix domain DUF1704 PF08014.9 MSTRG.5942.1_2 - 1.1e-14 54.1 0.6 2.2e-13 49.9 0.0 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF1704) CABIT PF12736.5 MSTRG.29029.1_3 - 6.6e-08 32.1 0.0 7.9e-08 31.8 0.0 1.0 1 0 0 1 1 1 1 Cell-cycle sustaining, positive selection, PDZ PF00595.22 MSTRG.470.1_3 - 1.7e-14 53.8 0.1 2.8e-14 53.1 0.1 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.470.1_3 - 0.00055 20.1 0.0 0.001 19.2 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Cyclin_N PF00134.21 MSTRG.17863.1_1 - 4.7e-49 165.3 0.2 8.8e-49 164.4 0.2 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_N2 PF16500.3 MSTRG.17863.1_1 - 1.3e-36 126.3 3.5 2.2e-36 125.5 3.5 1.4 1 0 0 1 1 1 1 N-terminal region of cyclin_N Cyclin_C PF02984.17 MSTRG.17863.1_1 - 1.1e-30 106.0 0.2 1.1e-30 106.0 0.2 2.2 3 0 0 3 3 3 1 Cyclin, C-terminal domain CLZ PF16526.3 MSTRG.8177.1_1 - 4e-27 94.2 4.2 6.4e-27 93.6 4.2 1.3 1 0 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels cNMP_binding PF00027.27 MSTRG.8177.1_1 - 2.8e-18 65.6 0.0 4.5e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Myosin_tail_1 PF01576.17 MSTRG.4047.1_2 - 4e-21 74.5 33.0 4.6e-21 74.3 33.0 1.0 1 0 0 1 1 1 1 Myosin tail Exonuc_VII_L PF02601.13 MSTRG.4047.1_2 - 0.00092 18.7 11.1 0.0013 18.3 11.1 1.1 1 0 0 1 1 1 1 Exonuclease VII, large subunit Rootletin PF15035.4 MSTRG.4047.1_2 - 0.0056 16.6 10.7 0.0056 16.6 10.7 2.2 1 1 1 2 2 2 1 Ciliary rootlet component, centrosome cohesion Apolipoprotein PF01442.16 MSTRG.4047.1_2 - 0.077 12.8 19.6 0.13 12.0 19.6 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF1818 PF08848.9 MSTRG.4047.1_2 - 2 8.4 12.5 0.37 10.7 3.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1818) Mit_KHE1 PF10173.7 MSTRG.4047.1_2 - 2.4 8.1 13.2 0.19 11.6 4.7 2.1 1 1 1 2 2 2 0 Mitochondrial K+-H+ exchange-related Fib_alpha PF08702.8 MSTRG.4047.1_2 - 2.9 7.9 14.4 4.5 7.3 13.7 1.7 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Alanine_zipper PF11839.6 MSTRG.4047.1_2 - 3.3 7.9 13.2 0.3 11.2 6.5 2.2 2 1 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein DUF1664 PF07889.10 MSTRG.4047.1_2 - 3.6 7.5 13.3 3.9 7.3 3.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Orthopox_A5L PF06193.9 MSTRG.4047.1_2 - 7.6 5.8 6.3 3.6 6.8 3.9 1.6 2 0 0 2 2 2 0 Orthopoxvirus A5L protein-like Fzo_mitofusin PF04799.11 MSTRG.4047.1_2 - 8.6 5.7 16.8 5 6.5 4.6 2.7 1 1 1 2 2 2 0 fzo-like conserved region A_deaminase PF00962.20 MSTRG.3267.2_3 - 2.2e-129 431.3 0.2 5.3e-129 430.1 0.2 1.6 1 1 0 1 1 1 1 Adenosine/AMP deaminase GILT PF03227.14 MSTRG.10590.1_3 - 5.5e-31 106.8 3.5 1.3e-30 105.6 3.5 1.7 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) SapA PF02199.13 MSTRG.10590.1_3 - 2.5e-05 24.2 1.2 7.4e-05 22.7 1.2 1.8 1 0 0 1 1 1 1 Saposin A-type domain Vps51 PF08700.9 MSTRG.15066.1_3 - 4.5e-20 71.4 6.0 8.6e-20 70.5 6.0 1.5 1 0 0 1 1 1 1 Vps51/Vps67 COG2 PF06148.9 MSTRG.15066.1_3 - 3.1e-06 27.2 3.6 3.8e-06 26.9 3.6 1.1 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 COG5 PF10392.7 MSTRG.15066.1_3 - 0.011 15.8 4.8 0.014 15.4 4.4 1.4 1 1 0 1 1 1 0 Golgi transport complex subunit 5 Metal_resist PF13801.4 MSTRG.15066.1_3 - 0.087 12.9 0.2 4.9 7.2 0.1 2.4 2 1 1 3 3 3 0 Heavy-metal resistance DUF3452 PF11934.6 MSTRG.15066.1_3 - 0.25 10.8 5.0 0.59 9.6 5.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3452) Prismane PF03063.18 MSTRG.15066.1_3 - 0.27 9.8 1.7 0.33 9.4 1.7 1.0 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family ERp29 PF07749.10 MSTRG.15066.1_3 - 0.54 11.1 6.1 0.26 12.1 3.3 1.9 1 1 1 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain SGS PF05002.13 MSTRG.15066.1_3 - 0.54 10.3 4.1 5.2 7.1 0.8 2.2 1 1 1 2 2 2 0 SGS domain Exonuc_VII_L PF02601.13 MSTRG.15066.1_3 - 0.56 9.6 5.1 0.71 9.2 5.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit AIM5 PF17050.3 MSTRG.15066.1_3 - 0.68 10.1 3.5 1 9.6 1.0 2.0 2 0 0 2 2 2 0 Altered inheritance of mitochondria 5 SPT16 PF08644.9 MSTRG.15066.1_3 - 0.84 9.7 5.9 0.74 9.8 0.2 2.1 1 1 1 2 2 2 0 FACT complex subunit (SPT16/CDC68) Hormone_recep PF00104.28 MSTRG.22371.1_2 - 7.7e-21 74.5 0.2 1.1e-09 38.1 0.0 2.5 3 0 0 3 3 3 2 Ligand-binding domain of nuclear hormone receptor GCOM2 PF15328.4 MSTRG.22371.1_2 - 0.029 14.6 0.9 0.059 13.6 0.9 1.5 1 0 0 1 1 1 0 Putative GRINL1B complex locus protein 2 CDK2AP PF09806.7 MSTRG.22371.1_2 - 0.47 10.3 5.9 2.2 8.2 5.2 2.0 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein SUIM_assoc PF16619.3 MSTRG.22371.1_2 - 0.69 9.9 12.4 3 7.9 0.2 2.3 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 SAPIS-gp6 PF16722.3 MSTRG.22371.1_2 - 6 7.2 6.8 5.7 7.3 0.4 2.4 2 0 0 2 2 2 0 Pathogenicity island protein gp6 in Staphylococcus Tmemb_18A PF09771.7 MSTRG.5437.1_3 - 4.6e-58 194.6 0.0 6.4e-58 194.2 0.0 1.2 1 0 0 1 1 1 1 Transmembrane protein 188 MARVEL PF01284.21 MSTRG.15644.1_2 - 1.5e-20 73.6 30.6 8e-14 51.8 9.2 2.6 3 0 0 3 3 3 2 Membrane-associating domain C2-set_2 PF08205.10 MSTRG.23987.1_3 - 1.4e-10 40.9 0.0 3.8e-10 39.6 0.0 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 MSTRG.23987.1_3 - 1.6e-05 25.3 0.0 0.13 12.7 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 MSTRG.23987.1_3 - 0.0069 16.3 0.0 2.5 8.1 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain DUF572 PF04502.11 MSTRG.8978.2_1 - 1.3e-12 47.9 1.8 1.4e-12 47.7 1.8 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) MAT1 PF06391.11 MSTRG.8978.2_1 - 0.03 14.0 2.6 0.041 13.6 2.6 1.2 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 PNISR PF15996.3 MSTRG.8978.2_1 - 0.038 14.1 5.4 0.046 13.8 5.4 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Gelsolin PF00626.20 MSTRG.25365.3_2 - 3.7e-21 74.7 0.1 2e-05 24.2 0.0 5.8 5 0 0 5 5 5 5 Gelsolin repeat DUF4695 PF15766.3 MSTRG.25365.3_2 - 0.00041 20.4 1.8 0.25 11.5 0.0 3.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4695) FAM222A PF15258.4 MSTRG.3080.1_1 - 9.8e-49 166.7 21.7 3.5e-32 112.1 3.4 2.6 1 1 1 2 2 2 2 Protein family of FAM222A Spt20 PF12090.6 MSTRG.3080.1_1 - 0.06 12.8 5.7 0.16 11.4 5.7 1.6 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.11 MSTRG.3080.1_1 - 0.087 12.7 7.7 0.12 12.2 7.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.7 MSTRG.3080.1_2 - 1.4 8.3 9.9 2.7 7.4 9.9 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IMUP PF15761.3 MSTRG.3080.1_2 - 2.1 9.0 6.5 4 8.0 6.5 1.4 1 0 0 1 1 1 0 Immortalisation up-regulated protein Mito_carr PF00153.25 MSTRG.19466.1_1 - 2.5e-63 209.9 2.0 4.5e-20 71.2 0.2 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein Aldedh PF00171.20 MSTRG.17322.1_1 - 2.5e-181 603.1 0.0 3e-181 602.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.9 MSTRG.17322.1_1 - 0.1 11.9 0.3 6 6.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) zf-CHY PF05495.10 MSTRG.17322.1_3 - 1.3 9.5 6.4 0.5 10.8 2.8 2.1 2 0 0 2 2 2 0 CHY zinc finger UPAR_LY6 PF00021.19 MSTRG.7914.1_3 - 0.00016 22.1 10.9 0.00041 20.9 10.9 1.7 1 0 0 1 1 1 1 u-PAR/Ly-6 domain DUF1510 PF07423.9 MSTRG.18802.3_2 - 0.11 11.8 4.0 0.19 11.0 4.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF4611 PF15387.4 MSTRG.18802.3_2 - 0.17 12.0 7.7 0.32 11.1 7.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) YL1 PF05764.11 MSTRG.18802.3_2 - 0.28 11.2 8.7 0.43 10.6 8.7 1.1 1 0 0 1 1 1 0 YL1 nuclear protein DNA_pol_phi PF04931.11 MSTRG.18802.3_2 - 8.4 4.2 11.8 13 3.6 11.8 1.2 1 0 0 1 1 1 0 DNA polymerase phi Rdx PF10262.7 MSTRG.2490.2_3 - 8.5e-09 35.3 0.0 2.4e-08 33.9 0.0 1.8 1 1 0 1 1 1 1 Rdx family ATG16 PF08614.9 MSTRG.614.4_2 - 1.5e-43 149.2 25.6 1.5e-43 149.2 25.6 1.7 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) WD40 PF00400.30 MSTRG.614.4_2 - 1.7e-26 91.8 2.8 2.8e-07 31.0 0.0 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.614.4_2 - 0.00013 22.0 0.0 0.57 10.4 0.0 3.7 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain KASH_CCD PF14662.4 MSTRG.614.4_2 - 0.00018 21.3 25.6 0.00029 20.6 9.4 2.7 3 0 0 3 3 3 2 Coiled-coil region of CCDC155 or KASH ADIP PF11559.6 MSTRG.614.4_2 - 0.0025 17.8 9.6 0.0025 17.8 9.6 2.3 1 1 1 2 2 2 1 Afadin- and alpha -actinin-Binding Nup160 PF11715.6 MSTRG.614.4_2 - 0.0029 16.2 0.7 1.7 7.0 0.1 3.6 1 1 3 4 4 4 1 Nucleoporin Nup120/160 eIF2A PF08662.9 MSTRG.614.4_2 - 0.1 12.3 0.0 2.6 7.8 0.0 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A DUF4407 PF14362.4 MSTRG.614.4_2 - 0.4 9.9 20.7 0.67 9.1 20.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fez1 PF06818.13 MSTRG.614.4_2 - 0.45 10.8 24.4 0.27 11.5 22.2 1.7 1 1 1 2 2 2 0 Fez1 V_ATPase_I PF01496.17 MSTRG.614.4_2 - 0.62 7.8 11.3 0.85 7.3 11.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Jnk-SapK_ap_N PF09744.7 MSTRG.614.4_2 - 0.72 9.9 22.2 4.5 7.3 22.0 2.3 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF4472 PF14739.4 MSTRG.614.4_2 - 0.81 10.3 22.1 0.088 13.4 3.5 3.4 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) Phage_GPO PF05929.9 MSTRG.614.4_2 - 0.88 9.0 14.3 0.34 10.4 10.7 2.0 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase TRAF_BIRC3_bd PF16673.3 MSTRG.614.4_2 - 0.93 9.2 5.9 14 5.4 2.1 2.9 3 0 0 3 3 2 0 TNF receptor-associated factor BIRC3 binding domain DUF1664 PF07889.10 MSTRG.614.4_2 - 1 9.2 5.0 1.9 8.4 4.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Syntaxin-6_N PF09177.9 MSTRG.614.4_2 - 1.2 9.6 12.7 0.26 11.7 2.3 2.8 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF3584 PF12128.6 MSTRG.614.4_2 - 1.5 6.1 23.1 2 5.7 23.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TPR_MLP1_2 PF07926.10 MSTRG.614.4_2 - 2.8 7.9 33.0 0.027 14.4 13.7 2.5 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein FUSC PF04632.10 MSTRG.614.4_2 - 6.1 5.1 11.2 9 4.6 11.2 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family NPV_P10 PF05531.10 MSTRG.614.4_2 - 6.3 7.2 6.1 10 6.5 1.9 2.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein OmpH PF03938.12 MSTRG.614.4_2 - 6.8 6.5 36.6 2.1 8.2 14.6 2.4 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) APG6 PF04111.10 MSTRG.614.4_2 - 7 5.8 25.6 4.8 6.4 23.8 1.6 1 1 1 2 2 2 0 Autophagy protein Apg6 IncA PF04156.12 MSTRG.614.4_2 - 8.1 6.1 29.2 1.2e+03 -1.1 29.0 2.3 1 1 0 1 1 1 0 IncA protein DUF812 PF05667.9 MSTRG.614.4_2 - 9.4 4.9 23.5 14 4.3 23.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) PTH2 PF01981.14 MSTRG.15023.2_1 - 1.4e-07 31.6 0.1 1.8e-07 31.2 0.1 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 PTH2 PF01981.14 MSTRG.15023.2_2 - 9.1e-10 38.7 0.0 1.4e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Atg8 PF02991.14 MSTRG.5945.1_3 - 2.5e-49 165.6 0.1 3.8e-49 165.0 0.1 1.3 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.11 MSTRG.5945.1_3 - 2.3e-05 24.6 0.0 3.4e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 DNA_pol_A_exo1 PF01612.18 MSTRG.17726.2_2 - 1.3e-09 37.9 0.1 2.3e-09 37.1 0.1 1.3 1 0 0 1 1 1 1 3'-5' exonuclease PH_5 PF15405.4 MSTRG.17726.2_2 - 0.15 12.0 0.7 0.44 10.5 0.1 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain START PF01852.17 MSTRG.5695.1_2 - 3.4e-33 114.7 0.9 4.9e-33 114.2 0.4 1.5 2 0 0 2 2 2 1 START domain PH PF00169.27 MSTRG.5695.1_2 - 4.5e-13 49.5 0.5 1.1e-12 48.2 0.5 1.7 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 MSTRG.5695.1_2 - 1e-05 25.6 0.1 2.8e-05 24.2 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.4 MSTRG.5695.1_2 - 1.5e-05 25.2 2.3 0.00056 20.2 2.3 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain Acyl_CoA_thio PF02551.13 MSTRG.5695.1_2 - 0.051 13.3 0.0 0.096 12.4 0.0 1.3 1 0 0 1 1 1 0 Acyl-CoA thioesterase Myb_Cef PF11831.6 MSTRG.26333.1_1 - 6e-78 261.5 5.6 6e-78 261.5 5.6 2.4 3 0 0 3 3 3 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.29 MSTRG.26333.1_2 - 5e-21 74.4 7.5 6.8e-12 45.2 1.9 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 MSTRG.26333.1_2 - 2.4e-19 69.2 5.0 1.1e-13 51.0 4.6 2.7 1 1 1 2 2 2 2 Myb-like DNA-binding domain Rap1_C PF11626.6 MSTRG.26333.1_2 - 0.016 15.2 0.2 0.056 13.4 0.2 1.9 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain PDZ PF00595.22 MSTRG.6315.1_2 - 3.2e-13 49.7 0.0 5.9e-13 48.8 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.6315.1_2 - 0.00095 19.3 0.0 0.0018 18.4 0.0 1.4 1 0 0 1 1 1 1 PDZ domain DUF3338 PF11819.6 MSTRG.6315.1_2 - 0.0025 17.7 0.1 0.0051 16.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3338) GNAT_acetyltr_2 PF13718.4 MSTRG.25112.1_3 - 7.3e-100 332.9 0.0 4e-99 330.5 0.0 2.2 2 0 0 2 2 2 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.4 MSTRG.25112.1_3 - 1.2e-75 254.1 5.5 2.4e-75 253.1 5.5 1.5 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.12 MSTRG.25112.1_3 - 2.2e-64 216.4 0.0 7.8e-64 214.6 0.0 2.0 1 0 0 1 1 1 1 Helicase DUF1726 PF08351.9 MSTRG.25112.1_3 - 6.3e-34 115.6 1.1 1.4e-33 114.5 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1726) Acetyltransf_7 PF13508.5 MSTRG.25112.1_3 - 0.00045 20.5 0.0 0.0022 18.2 0.0 2.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.23 MSTRG.25112.1_3 - 0.0072 16.4 0.0 0.024 14.7 0.0 1.9 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Selenoprotein_S PF06936.9 MSTRG.25112.1_3 - 0.18 11.5 6.4 0.49 10.0 6.4 1.7 1 0 0 1 1 1 0 Selenoprotein S (SelS) BRCA2 PF00634.16 MSTRG.8372.1_3 - 0.052 12.9 0.0 0.087 12.2 0.0 1.3 1 0 0 1 1 1 0 BRCA2 repeat Turandot PF07240.9 MSTRG.14148.1_2 - 0.019 14.8 0.0 0.036 13.9 0.0 1.3 1 0 0 1 1 1 0 Stress-inducible humoral factor Turandot TH1 PF04858.11 MSTRG.14148.1_3 - 7.5e-274 909.6 0.1 9.5e-274 909.3 0.1 1.1 1 0 0 1 1 1 1 TH1 protein Cofilin_ADF PF00241.18 MSTRG.8030.1_3 - 1.9e-30 105.5 0.5 3.2e-30 104.8 0.5 1.4 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein I_LWEQ PF01608.15 MSTRG.16852.3_2 - 9e-51 172.0 4.4 9e-51 172.0 4.4 1.8 2 0 0 2 2 2 1 I/LWEQ domain ANTH PF07651.14 MSTRG.16852.3_3 - 2.6e-64 216.8 0.4 2.6e-64 216.8 0.4 2.0 2 0 0 2 2 2 1 ANTH domain HIP1_clath_bdg PF16515.3 MSTRG.16852.3_3 - 1.5e-33 115.2 18.8 1.5e-33 115.2 18.8 4.4 3 1 1 4 4 4 3 Clathrin-binding domain of Huntingtin-interacting protein 1 Spc7 PF08317.9 MSTRG.16852.3_3 - 4.5 5.9 53.0 7.6 5.2 25.2 2.7 1 1 1 2 2 2 0 Spc7 kinetochore protein Myosin_head PF00063.19 MSTRG.13886.1_1 - 8.8e-279 926.3 0.9 8.8e-279 926.3 0.9 2.4 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 MSTRG.13886.1_1 - 2.9e-158 528.6 261.8 3.5e-158 528.3 261.8 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.17 MSTRG.13886.1_1 - 1.6e-09 37.3 1.8 4.8e-09 35.8 1.8 1.9 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Syntaxin-6_N PF09177.9 MSTRG.13886.1_1 - 0.0027 18.1 6.9 0.0027 18.1 6.9 12.9 2 2 6 10 10 10 1 Syntaxin 6, N-terminal IQ PF00612.25 MSTRG.13886.1_1 - 0.033 13.8 0.0 0.1 12.3 0.0 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif Reo_sigmaC PF04582.10 MSTRG.13886.1_1 - 0.036 13.4 75.6 0.17 11.1 1.8 8.8 1 1 9 10 10 10 0 Reovirus sigma C capsid protein AAA_22 PF13401.4 MSTRG.13886.1_1 - 0.062 13.4 0.0 0.062 13.4 0.0 4.6 3 2 1 4 4 4 0 AAA domain AAA_16 PF13191.4 MSTRG.13886.1_1 - 0.68 10.2 0.0 0.68 10.2 0.0 5.3 4 3 1 5 5 5 0 AAA ATPase domain DP PF08781.8 MSTRG.22315.1_2 - 1.8e-62 209.1 1.3 1.8e-62 209.1 1.3 1.9 2 0 0 2 2 2 1 Transcription factor DP E2F_TDP PF02319.18 MSTRG.22315.1_2 - 8e-26 89.7 0.1 1.5e-25 88.8 0.1 1.5 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain RRM_1 PF00076.20 MSTRG.23587.2_1 - 3.4e-12 45.9 0.0 5.1e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 MSTRG.23587.2_1 - 8e-05 22.1 0.0 0.00013 21.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP PF02037.25 MSTRG.23587.2_2 - 4.5e-08 32.5 0.7 8.2e-08 31.7 0.7 1.5 1 0 0 1 1 1 1 SAP domain HTH_28 PF13518.4 MSTRG.26479.1_1 - 0.0049 16.8 5.0 0.0087 16.0 5.0 1.5 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_1 PF01527.18 MSTRG.26479.1_1 - 0.043 14.0 0.8 0.061 13.5 0.8 1.2 1 0 0 1 1 1 0 Transposase HTH_23 PF13384.4 MSTRG.26479.1_1 - 0.086 12.5 2.8 0.13 12.0 2.5 1.4 1 1 0 1 1 1 0 Homeodomain-like domain UDPGT PF00201.16 MSTRG.14838.4_2 - 7.5e-185 615.3 0.9 8.6e-185 615.1 0.9 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 MSTRG.14838.4_2 - 1.4e-05 25.0 0.0 2.5e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.4 MSTRG.14838.4_2 - 0.00014 21.7 0.0 0.0014 18.5 0.0 2.3 1 1 0 1 1 1 1 Glycosyltransferase Family 4 DUF4312 PF14189.4 MSTRG.14838.4_2 - 0.11 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4312) Ion_trans PF00520.29 MSTRG.13285.1_3 - 5e-53 179.7 39.5 1.6e-27 96.1 23.2 2.3 2 0 0 2 2 2 2 Ion transport protein Caleosin PF05042.11 MSTRG.13285.1_3 - 0.01 15.7 0.0 0.032 14.0 0.0 1.8 1 0 0 1 1 1 0 Caleosin related protein DUF3278 PF11683.6 MSTRG.13285.1_3 - 0.28 11.1 5.3 0.14 12.1 1.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3278) PET PF06297.12 MSTRG.22565.1_2 - 8.3e-35 118.8 0.3 1.4e-34 118.1 0.3 1.4 1 0 0 1 1 1 1 PET Domain LIM PF00412.20 MSTRG.22565.1_2 - 2.1e-29 101.4 47.2 3.2e-13 49.6 3.4 4.6 4 1 0 4 4 4 3 LIM domain CIAPIN1 PF05093.11 MSTRG.22565.1_2 - 0.059 13.8 0.5 0.059 13.8 0.5 3.0 3 0 0 3 3 3 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Rho_Binding PF08912.9 MSTRG.8351.3_1 - 4.2e-24 85.0 13.3 4.2e-24 85.0 13.3 9.3 4 2 5 9 9 9 1 Rho Binding PH PF00169.27 MSTRG.8351.3_1 - 5.3e-07 30.0 0.1 0.00079 19.8 0.0 3.1 2 0 0 2 2 2 2 PH domain C1_1 PF00130.20 MSTRG.8351.3_1 - 0.0009 19.0 5.3 0.0019 17.9 5.3 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Sec23_trunk PF04811.13 MSTRG.24565.1_2 - 1.4e-82 276.8 0.1 2.1e-82 276.2 0.1 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.13 MSTRG.24565.1_2 - 5e-22 77.5 0.7 8.8e-22 76.7 0.7 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.10 MSTRG.24565.1_2 - 1.1e-16 61.2 0.3 2.3e-16 60.2 0.0 1.7 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.13 MSTRG.24565.1_2 - 1.8e-13 50.1 9.9 6.3e-13 48.4 9.9 2.0 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.20 MSTRG.24565.1_2 - 2e-10 40.3 0.0 5.7e-10 38.8 0.0 1.8 2 0 0 2 2 2 1 Gelsolin repeat Couple_hipA PF13657.4 MSTRG.10955.3_1 - 0.093 13.2 0.1 0.19 12.3 0.1 1.5 1 0 0 1 1 1 0 HipA N-terminal domain 7tm_1 PF00001.19 MSTRG.10955.3_2 - 1e-10 41.2 17.2 1.6e-10 40.6 17.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF996 PF06195.11 MSTRG.10955.3_2 - 0.94 9.6 9.5 0.28 11.3 4.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF996) Proteasome PF00227.24 MSTRG.13852.1_1 - 1.2e-56 191.1 0.1 1.9e-56 190.5 0.1 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.7 MSTRG.13852.1_1 - 1.2e-13 50.3 0.0 2.3e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature SelP_N PF04592.12 MSTRG.20903.1_1 - 4.7 6.4 14.9 6.1 6.0 14.9 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF4106 PF13388.4 MSTRG.20903.1_2 - 5.9 5.9 5.8 7.6 5.5 5.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Gelsolin PF00626.20 MSTRG.12169.1_3 - 2.6e-92 302.7 0.0 6.5e-17 61.1 0.0 6.9 7 1 0 7 7 7 6 Gelsolin repeat MHC_I PF00129.16 MSTRG.19692.3_1 - 1.1e-15 57.6 0.1 1.6e-15 57.0 0.1 1.1 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 MHC_I PF00129.16 MSTRG.19692.3_2 - 2.9e-16 59.4 1.0 4.4e-16 58.8 1.0 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Drf_FH1 PF06346.10 MSTRG.21857.1_1 - 3 7.4 16.0 6 6.4 16.0 1.5 1 0 0 1 1 1 0 Formin Homology Region 1 SAGA-Tad1 PF12767.5 MSTRG.21857.1_2 - 0.34 10.5 6.9 0.72 9.4 6.9 1.5 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit DARPP-32 PF05395.10 MSTRG.2438.1_2 - 2.4e-45 154.5 2.0 3.3e-45 154.1 2.0 1.2 1 0 0 1 1 1 1 Protein phosphatase inhibitor 1/DARPP-32 LRR19-TM PF15176.4 MSTRG.12686.1_2 - 4.6e-19 68.2 0.0 9e-18 64.1 0.0 2.3 1 1 1 2 2 2 2 Leucine-rich repeat family 19 TM domain PMP22_Claudin PF00822.18 MSTRG.27122.1_2 - 3.3e-34 118.0 12.1 3.3e-34 118.0 12.1 1.7 2 0 0 2 2 2 1 PMP-22/EMP/MP20/Claudin family DUF973 PF06157.9 MSTRG.27122.1_2 - 0.44 9.4 7.1 0.88 8.4 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF973) Mem_trans PF03547.16 MSTRG.18281.2_2 - 1.3e-19 69.8 15.6 5.4e-13 48.0 1.9 2.5 1 1 1 2 2 2 2 Membrane transport protein Caveolin PF01146.15 MSTRG.22566.2_2 - 1.4e-48 164.1 0.3 2.2e-48 163.5 0.3 1.3 1 0 0 1 1 1 1 Caveolin PAS_11 PF14598.4 MSTRG.12307.1_1 - 5.7e-25 87.5 0.2 3.5e-21 75.3 0.1 2.4 2 0 0 2 2 2 2 PAS domain PAS PF00989.23 MSTRG.12307.1_1 - 7.6e-20 70.9 0.0 1.7e-08 34.3 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_3 PF08447.10 MSTRG.12307.1_1 - 6.4e-19 67.9 0.1 1.2e-10 41.4 0.0 2.3 2 0 0 2 2 2 2 PAS fold HLH PF00010.24 MSTRG.12307.1_1 - 3.5e-17 62.0 0.8 7.1e-17 61.0 0.8 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.5 MSTRG.12307.1_1 - 4.8e-08 33.1 0.0 1.9e-05 24.7 0.0 2.4 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.8 MSTRG.12307.1_1 - 0.00078 19.5 0.0 0.21 11.7 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_2 PF08446.9 MSTRG.12307.1_1 - 0.032 14.8 0.0 0.15 12.6 0.0 2.0 2 0 0 2 2 2 0 PAS fold I-set PF07679.14 MSTRG.5562.1_3 - 1.9e-42 143.1 0.0 1.4e-16 60.1 0.0 3.7 4 0 0 4 4 4 3 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.5562.1_3 - 4.9e-39 132.7 0.2 1.8e-13 50.8 0.0 4.1 4 0 0 4 4 4 3 Immunoglobulin domain fn3 PF00041.19 MSTRG.5562.1_3 - 4.2e-36 123.0 4.7 3.3e-14 52.9 0.2 3.5 3 0 0 3 3 3 3 Fibronectin type III domain Ig_2 PF13895.4 MSTRG.5562.1_3 - 2.8e-30 104.3 0.0 2.5e-10 40.4 0.0 3.7 4 0 0 4 4 3 3 Immunoglobulin domain ig PF00047.23 MSTRG.5562.1_3 - 1e-24 86.3 0.0 8.1e-07 29.0 0.0 3.9 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 MSTRG.5562.1_3 - 6e-13 48.8 3.3 0.19 11.7 0.0 7.8 5 3 3 8 8 8 4 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.3 MSTRG.5562.1_3 - 4.4e-09 36.7 5.1 0.0031 17.9 0.1 4.1 4 0 0 4 4 4 2 Purple acid Phosphatase, N-terminal domain C2-set_2 PF08205.10 MSTRG.5562.1_3 - 7.6e-09 35.4 0.1 0.015 15.2 0.0 3.6 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 MSTRG.5562.1_3 - 8.1e-05 22.8 0.0 0.59 10.4 0.0 4.0 5 0 0 5 5 5 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Interfer-bind PF09294.8 MSTRG.5562.1_3 - 0.044 14.0 0.0 12 6.2 0.0 3.3 3 0 0 3 3 3 0 Interferon-alpha/beta receptor, fibronectin type III G6B PF15096.4 MSTRG.5562.1_3 - 0.053 13.1 0.0 0.13 11.8 0.0 1.7 1 0 0 1 1 1 0 G6B family Pkinase PF00069.23 MSTRG.9094.1_2 - 5.1e-71 239.0 0.5 6.4e-71 238.7 0.5 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.9094.1_2 - 1.5e-20 73.5 0.0 2.1e-20 73.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 MSTRG.9094.1_2 - 5.8e-07 29.5 0.1 3.8e-05 23.6 0.2 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.12 MSTRG.9094.1_2 - 0.0037 16.5 0.1 0.0061 15.8 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.18 MSTRG.9094.1_2 - 0.031 13.7 0.5 0.065 12.7 0.5 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase ABC1 PF03109.14 MSTRG.9094.1_2 - 0.16 12.0 0.0 0.3 11.1 0.0 1.3 1 0 0 1 1 1 0 ABC1 family Rrp44_S1 PF17215.1 MSTRG.28445.1_1 - 0.058 13.2 0.0 0.076 12.9 0.0 1.1 1 0 0 1 1 1 0 S1 domain WH1 PF00568.21 MSTRG.11712.2_2 - 1.5e-29 102.0 0.0 2.3e-29 101.5 0.0 1.2 1 0 0 1 1 1 1 WH1 domain PBD PF00786.26 MSTRG.11712.2_2 - 4.1e-19 68.6 0.1 8e-19 67.7 0.1 1.5 1 0 0 1 1 1 1 P21-Rho-binding domain DUF4918 PF16265.3 MSTRG.11712.2_2 - 0.0072 15.7 0.0 0.08 12.3 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4918) Ank_2 PF12796.5 MSTRG.7552.1_2 - 1.5e-56 188.8 13.9 1.3e-15 57.6 0.1 5.9 4 1 3 7 7 7 5 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.7552.1_2 - 2e-48 162.0 10.9 2e-11 44.1 0.0 9.4 6 3 4 10 10 10 8 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.7552.1_2 - 1.6e-42 138.5 13.3 0.0017 18.5 0.0 11.8 13 0 0 13 13 13 9 Ankyrin repeat Ank PF00023.28 MSTRG.7552.1_2 - 1.2e-41 139.2 24.6 8.8e-05 22.7 0.1 10.9 9 1 1 10 10 10 9 Ankyrin repeat Ank_5 PF13857.4 MSTRG.7552.1_2 - 2.9e-30 103.7 18.5 2.1e-05 24.6 0.1 9.6 3 3 5 9 9 9 8 Ankyrin repeats (many copies) SOCS_box PF07525.14 MSTRG.7552.1_2 - 5.4e-09 36.1 7.3 1.5e-08 34.7 7.3 1.8 1 0 0 1 1 1 1 SOCS box Caskin-Pro-rich PF16907.3 MSTRG.26095.1_1 - 0.86 10.0 4.0 0.28 11.6 0.4 2.0 2 0 0 2 2 2 0 Proline rich region of Caskin proteins fn3 PF00041.19 MSTRG.26095.1_3 - 0.0011 19.2 0.0 0.0025 18.0 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III domain DUF3450 PF11932.6 MSTRG.17708.2_1 - 0.0052 16.0 4.4 0.4 9.8 0.6 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF3450) DUF3540 PF12059.6 MSTRG.17708.2_1 - 0.0083 15.8 1.1 0.02 14.5 1.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF3540) MscS_porin PF12795.5 MSTRG.17708.2_1 - 0.088 12.2 6.4 0.42 10.0 6.4 1.9 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain Exonuc_VII_L PF02601.13 MSTRG.17708.2_1 - 0.82 9.0 5.4 1.1 8.7 5.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF16 PF01519.14 MSTRG.17708.2_1 - 1.1 9.6 8.1 28 5.1 7.6 2.2 1 1 0 1 1 1 0 Protein of unknown function DUF16 TMPIT PF07851.11 MSTRG.17708.2_1 - 1.2 8.2 9.2 0.7 8.9 6.8 1.6 1 1 1 2 2 2 0 TMPIT-like protein TMF_TATA_bd PF12325.6 MSTRG.17708.2_1 - 1.5 8.9 14.4 0.2 11.8 6.3 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding ATG16 PF08614.9 MSTRG.17708.2_1 - 3.3 7.7 10.9 0.42 10.6 3.6 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.10 MSTRG.17708.2_1 - 9.5 6.1 10.3 87 3.0 0.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ARD PF03079.12 MSTRG.1184.1_1 - 1.2e-53 181.4 0.5 1.6e-53 180.9 0.5 1.2 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.9 MSTRG.1184.1_1 - 2.2e-07 30.4 0.0 5e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.17 MSTRG.1184.1_1 - 0.00015 21.5 0.0 0.00029 20.6 0.0 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain CH_2 PF06294.9 MSTRG.15849.1_3 - 6.3e-31 106.2 0.0 1.1e-30 105.4 0.0 1.4 1 0 0 1 1 1 1 CH-like domain in sperm protein CAMSAP_CH PF11971.6 MSTRG.15849.1_3 - 4.8e-06 26.2 0.0 1.3e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain zf-C2H2 PF00096.24 MSTRG.23128.2_3 - 1.3e-18 66.2 34.6 3.9e-05 23.7 0.5 5.6 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.23128.2_3 - 1.1e-17 63.0 36.8 0.00033 21.1 0.4 6.0 6 0 0 6 6 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.4 MSTRG.23128.2_3 - 2.3e-15 56.1 39.1 9.2e-05 22.6 1.0 6.7 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2_6 PF13912.4 MSTRG.23128.2_3 - 6e-09 35.5 6.5 1.4e-06 28.0 1.2 6.6 7 0 0 7 7 7 4 C2H2-type zinc finger zf-met PF12874.5 MSTRG.23128.2_3 - 1.1e-08 35.1 21.1 0.0074 16.5 0.7 5.5 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.23128.2_3 - 1.8e-08 34.3 20.1 0.001 19.2 1.3 5.5 4 2 1 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-C2H2_assoc3 PF16637.3 MSTRG.23128.2_3 - 0.04 14.2 1.7 2.3 8.6 0.0 3.1 3 0 0 3 3 3 0 Putative zinc-finger between two C2H2 zinc-fingers on Patz Zn-ribbon_8 PF09723.8 MSTRG.23128.2_3 - 0.074 13.0 15.0 0.11 12.5 1.0 3.8 3 1 1 4 4 4 0 Zinc ribbon domain zf-C2H2_8 PF15909.3 MSTRG.23128.2_3 - 0.15 12.3 16.0 0.062 13.5 6.0 3.5 1 1 3 4 4 4 0 C2H2-type zinc ribbon zf-C2H2_2 PF12756.5 MSTRG.23128.2_3 - 0.24 11.6 19.5 4.8 7.4 2.1 4.8 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) Zn_ribbon_2 PF12674.5 MSTRG.23128.2_3 - 0.26 11.8 6.3 7.6 7.1 0.2 3.1 3 0 0 3 3 3 0 Putative zinc ribbon domain DUF629 PF04780.10 MSTRG.23128.2_3 - 0.27 9.6 13.3 0.48 8.8 0.8 3.1 1 1 3 4 4 4 0 Protein of unknown function (DUF629) DZR PF12773.5 MSTRG.23128.2_3 - 0.48 10.4 14.6 2.2e+02 1.8 11.0 3.7 1 1 1 2 2 2 0 Double zinc ribbon zf-C2H2_9 PF16293.3 MSTRG.23128.2_3 - 1 9.1 5.6 31 4.4 0.2 3.7 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) TFIIS_C PF01096.16 MSTRG.23128.2_3 - 5.1 6.9 0.0 5.1 6.9 0.0 3.9 4 1 0 4 4 4 0 Transcription factor S-II (TFIIS) zf-CW PF07496.13 MSTRG.17894.1_1 - 0.012 15.5 0.0 0.027 14.4 0.0 1.5 1 0 0 1 1 1 0 CW-type Zinc Finger RNA_pol_Rpb8 PF03870.13 MSTRG.17894.1_2 - 0.063 13.3 0.0 0.096 12.8 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb8 Myc_N PF01056.16 MSTRG.13316.2_3 - 6.4e-100 335.1 14.6 2.5e-99 333.2 14.6 1.9 1 1 0 1 1 1 1 Myc amino-terminal region HLH PF00010.24 MSTRG.13316.2_3 - 5.6e-11 42.1 1.2 1.3e-10 40.9 1.2 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Myc-LZ PF02344.13 MSTRG.13316.2_3 - 5.3e-06 26.3 8.2 1.8e-05 24.6 8.2 2.0 1 0 0 1 1 1 1 Myc leucine zipper domain SPX PF03105.17 MSTRG.13316.2_3 - 0.49 10.2 7.7 0.87 9.3 7.7 1.3 1 0 0 1 1 1 0 SPX domain CENP-B_dimeris PF09026.8 MSTRG.13316.2_3 - 4.3 7.7 15.6 11 6.3 15.6 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Astro_capsid_p PF12226.6 MSTRG.13316.2_3 - 5.9 5.8 7.3 10 5.0 7.3 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein SNAP-25 PF00835.17 MSTRG.5373.1_3 - 7e-14 51.7 0.3 1.4e-13 50.8 0.3 1.5 1 0 0 1 1 1 1 SNAP-25 family DUF5089 PF17002.3 MSTRG.5373.1_3 - 1.2e-06 28.4 0.5 1.9e-06 27.7 0.5 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF5089) XhlA PF10779.7 MSTRG.5373.1_3 - 0.017 15.2 10.7 0.059 13.4 1.2 3.1 2 1 1 3 3 3 0 Haemolysin XhlA V-SNARE_C PF12352.6 MSTRG.5373.1_3 - 0.032 14.4 3.2 0.06 13.5 0.1 2.8 2 2 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus DUF16 PF01519.14 MSTRG.5373.1_3 - 0.63 10.4 3.4 21 5.6 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 Snapin_Pallidin PF14712.4 MSTRG.5373.1_3 - 2.4 8.5 5.6 18 5.7 1.6 2.4 2 0 0 2 2 2 0 Snapin/Pallidin Transposase_22 PF02994.12 MSTRG.5373.1_3 - 2.9 6.5 8.2 0.059 12.1 1.6 1.4 2 0 0 2 2 2 0 L1 transposable element Use1 PF09753.7 MSTRG.5373.1_3 - 3.2 7.2 6.4 0.39 10.2 0.9 2.0 2 0 0 2 2 2 0 Membrane fusion protein Use1 14-3-3 PF00244.18 MSTRG.22815.1_1 - 4.3e-105 350.0 10.9 5.9e-105 349.5 10.9 1.2 1 0 0 1 1 1 1 14-3-3 protein DUF722 PF05263.9 MSTRG.22815.1_1 - 0.026 14.6 1.5 0.046 13.8 1.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF722) TRAM_LAG1_CLN8 PF03798.14 MSTRG.10749.2_1 - 2.2e-10 40.5 4.2 4.8e-10 39.4 4.2 1.5 1 0 0 1 1 1 1 TLC domain TRAM_LAG1_CLN8 PF03798.14 MSTRG.10749.2_3 - 3.2e-12 46.5 3.9 3.2e-12 46.5 3.9 1.7 2 0 0 2 2 2 1 TLC domain PRIMA1 PF16101.3 MSTRG.10749.2_3 - 0.18 11.7 0.5 0.37 10.7 0.5 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 PUB PF09409.8 MSTRG.4562.1_1 - 0.02 14.7 0.0 0.048 13.4 0.0 1.6 1 0 0 1 1 1 0 PUB domain DDE_3 PF13358.4 MSTRG.4562.1_3 - 0.16 11.6 0.1 0.26 10.9 0.1 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease Plexin_cytopl PF08337.10 MSTRG.24649.2_1 - 8.9e-56 189.6 0.1 1.2e-55 189.1 0.1 1.2 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Lamp PF01299.15 MSTRG.24649.2_1 - 0.0057 16.1 0.2 0.0092 15.4 0.2 1.3 1 0 0 1 1 1 1 Lysosome-associated membrane glycoprotein (Lamp) FtsL PF04999.11 MSTRG.24649.2_1 - 0.033 14.0 0.4 0.06 13.2 0.4 1.4 1 0 0 1 1 1 0 Cell division protein FtsL Ly49 PF08391.8 MSTRG.24649.2_1 - 0.033 14.4 1.5 0.038 14.2 0.4 1.7 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region DUF3169 PF11368.6 MSTRG.24649.2_1 - 0.045 13.2 0.1 0.071 12.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) SIT PF15330.4 MSTRG.24649.2_1 - 0.088 13.1 0.2 0.15 12.4 0.2 1.4 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT FAM163 PF15069.4 MSTRG.24649.2_1 - 0.092 13.1 0.3 0.14 12.4 0.3 1.3 1 0 0 1 1 1 0 FAM163 family DUF2746 PF10874.6 MSTRG.24649.2_1 - 0.11 12.7 0.0 0.57 10.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2746) Potass_KdpF PF09604.8 MSTRG.24649.2_1 - 2.6 8.0 5.2 7.1 6.6 5.2 1.8 1 0 0 1 1 1 0 F subunit of K+-transporting ATPase (Potass_KdpF) VPS9 PF02204.16 MSTRG.27184.1_3 - 3.5e-28 97.7 0.1 5.7e-28 97.0 0.1 1.3 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain G-patch PF01585.21 MSTRG.14016.6_1 - 2.5e-17 62.4 2.9 4.3e-17 61.6 2.9 1.4 1 0 0 1 1 1 1 G-patch domain zf-RanBP PF00641.16 MSTRG.14016.6_1 - 3.8e-10 38.8 1.5 9.8e-10 37.4 1.5 1.8 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others G-patch_2 PF12656.5 MSTRG.14016.6_1 - 1e-07 31.8 0.6 2.9e-07 30.3 0.6 1.8 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.20 MSTRG.14016.6_1 - 1.5e-07 31.0 0.0 1.8e-05 24.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HPHLAWLY PF14925.4 MSTRG.14016.6_2 - 0.088 11.3 0.0 0.12 10.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function Galactosyl_T PF01762.19 MSTRG.18300.1_3 - 3.2e-38 131.4 0.0 4.6e-38 130.9 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase HSP70 PF00012.18 MSTRG.1746.2_3 - 1.4e-14 53.1 0.1 1.6e-14 52.9 0.1 1.1 1 0 0 1 1 1 1 Hsp70 protein TAF4 PF05236.12 MSTRG.26166.1_3 - 1.3e-71 241.6 10.1 1.8e-71 241.0 10.1 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family TAFH PF07531.12 MSTRG.26166.1_3 - 2.2e-32 110.8 2.1 4.9e-32 109.7 2.1 1.6 1 0 0 1 1 1 1 NHR1 homology to TAF SAGA-Tad1 PF12767.5 MSTRG.26166.1_3 - 0.019 14.6 0.1 0.019 14.6 0.1 2.5 3 0 0 3 3 3 0 Transcriptional regulator of RNA polII, SAGA, subunit AAA_23 PF13476.4 MSTRG.26166.1_3 - 2.3 8.6 8.0 4.7 7.5 8.0 1.4 1 0 0 1 1 1 0 AAA domain PX PF00787.22 MSTRG.23431.1_1 - 7e-16 58.1 0.0 1.3e-15 57.2 0.0 1.4 1 0 0 1 1 1 1 PX domain RA PF00788.21 MSTRG.23431.1_1 - 0.12 12.9 0.0 0.24 11.9 0.0 1.5 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain IBR PF01485.19 MSTRG.23431.1_3 - 3.8e-17 62.1 36.7 3.3e-12 46.3 9.5 3.8 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.4 MSTRG.23431.1_3 - 0.00056 20.0 6.9 0.00056 20.0 6.9 4.2 3 0 0 3 3 3 1 Ring finger domain EF-hand_7 PF13499.4 MSTRG.17832.1_1 - 2.3e-18 66.3 2.1 6.3e-13 48.9 0.1 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 MSTRG.17832.1_1 - 3.3e-18 63.7 10.3 5.2e-07 28.6 1.1 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 MSTRG.17832.1_1 - 1.9e-15 55.3 9.0 1.9e-05 24.1 1.1 4.6 3 1 2 5 5 5 4 EF-hand domain EF-hand_8 PF13833.4 MSTRG.17832.1_1 - 6.2e-13 48.2 6.6 4.1e-05 23.1 1.4 3.4 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.17832.1_1 - 1.9e-11 42.8 10.2 3.6e-05 23.0 0.6 4.2 4 0 0 4 4 4 3 EF hand EF-hand_4 PF12763.5 MSTRG.17832.1_1 - 5.1e-05 23.0 3.8 0.25 11.2 0.1 3.1 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 MSTRG.17832.1_1 - 0.0026 17.9 0.2 0.079 13.2 0.0 2.5 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Basic PF01586.14 MSTRG.25453.1_2 - 2.7e-27 95.6 1.4 8.5e-27 94.0 1.4 1.9 1 0 0 1 1 1 1 Myogenic Basic domain HLH PF00010.24 MSTRG.25453.1_2 - 1.5e-13 50.3 0.7 2.5e-13 49.6 0.7 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Myf5 PF12232.6 MSTRG.25453.1_2 - 4.1e-11 43.3 3.6 4.1e-11 43.3 3.6 2.3 2 0 0 2 2 2 1 Myogenic determination factor 5 CH PF00307.29 MSTRG.21627.2_1 - 2.3e-31 108.1 5.4 2.7e-16 59.6 0.8 2.2 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.6 MSTRG.21627.2_1 - 0.026 14.2 0.1 5.4 6.8 0.0 2.5 2 0 0 2 2 2 0 CAMSAP CH domain CH_2 PF06294.9 MSTRG.21627.2_1 - 0.13 12.3 0.4 2.9 7.9 0.0 2.2 2 0 0 2 2 2 0 CH-like domain in sperm protein Pyr_redox_2 PF07992.12 MSTRG.25095.1_2 - 3.8e-17 62.3 0.0 1.7e-16 60.2 0.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 MSTRG.25095.1_2 - 0.089 11.9 0.1 18 4.3 0.0 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.10 MSTRG.25095.1_2 - 0.11 11.3 0.0 11 4.8 0.0 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein SAM_1 PF00536.28 MSTRG.20505.2_1 - 2.6e-12 46.8 0.0 4.1e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PHC2_SAM_assoc PF16616.3 MSTRG.20505.2_1 - 2.5e-08 34.6 1.4 4.1e-08 33.9 1.4 1.3 1 0 0 1 1 1 1 Unstructured region on Polyhomeotic-like protein 1 and 2 SAM_2 PF07647.15 MSTRG.20505.2_1 - 5.7e-06 26.2 0.0 9.3e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 MSTRG.20505.2_1 - 0.14 12.0 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain DAD PF02109.14 MSTRG.7005.2_3 - 4.9e-15 55.6 0.1 7.9e-15 55.0 0.1 1.3 1 0 0 1 1 1 1 DAD family SH2 PF00017.22 MSTRG.19215.2_2 - 4e-10 39.5 0.0 7.1e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.14 MSTRG.19215.2_2 - 0.00016 21.8 0.0 0.00037 20.6 0.0 1.7 1 0 0 1 1 1 1 SOCS box PTCB-BRCT PF12738.5 MSTRG.15700.3_1 - 5.9e-48 160.5 2.0 1.3e-19 69.7 0.0 5.0 5 0 0 5 5 5 4 twin BRCT domain BRCT PF00533.24 MSTRG.15700.3_1 - 4.1e-40 135.9 0.0 9.8e-11 41.8 0.0 6.3 6 1 0 6 6 6 5 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.3 MSTRG.15700.3_1 - 3.8e-29 100.8 0.0 8.3e-05 22.8 0.0 6.0 5 0 0 5 5 5 5 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.3 MSTRG.15700.3_1 - 1.7e-23 82.2 0.0 5e-17 61.5 0.0 3.9 3 0 0 3 3 3 2 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.3 MSTRG.15700.3_1 - 6.4e-17 61.5 0.1 5.6e-06 26.4 0.0 5.4 5 0 0 5 5 5 4 DNA ligase 3 BRCT domain BNIP2 PF12496.6 MSTRG.19727.5_2 - 5.3e-30 104.5 0.0 8.5e-30 103.8 0.0 1.3 1 0 0 1 1 1 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CRAL_TRIO_2 PF13716.4 MSTRG.19727.5_2 - 4.6e-29 101.2 0.1 6.7e-29 100.6 0.1 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.18 MSTRG.19727.5_2 - 7.4e-08 32.1 0.1 1.3e-07 31.4 0.1 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain PDZ PF00595.22 MSTRG.24993.1_3 - 7.2e-09 35.7 0.1 1.1e-08 35.1 0.1 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Vps52 PF04129.10 MSTRG.6732.1_2 - 6.5e-210 698.0 8.9 8.3e-210 697.7 8.9 1.1 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.7 MSTRG.6732.1_2 - 2.8e-08 32.5 10.4 2.8e-08 32.5 10.4 2.4 3 0 0 3 3 3 2 Exocyst complex component Sec3 Spc7 PF08317.9 MSTRG.6732.1_2 - 0.04 12.6 6.6 0.089 11.5 6.6 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3440 PF11922.6 MSTRG.6732.1_2 - 0.067 12.7 0.5 0.34 10.4 0.2 2.2 2 1 1 3 3 3 0 Domain of unknown function (DUF3440) COG2 PF06148.9 MSTRG.6732.1_2 - 0.084 12.8 3.3 0.3 11.1 3.3 1.9 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1664 PF07889.10 MSTRG.6732.1_2 - 0.29 11.0 8.6 0.027 14.3 2.5 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.7 MSTRG.6732.1_2 - 0.3 11.0 7.7 1 9.2 7.7 1.9 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cep57_MT_bd PF06657.11 MSTRG.6732.1_2 - 0.41 11.0 4.4 0.2 12.0 0.5 2.6 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 HIP1_clath_bdg PF16515.3 MSTRG.6732.1_2 - 2.3 8.8 7.6 1.5 9.3 4.1 2.4 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF2267 PF10025.7 MSTRG.6732.1_2 - 4.6 7.4 6.3 26 5.0 4.2 3.0 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2267) Copine PF07002.14 MSTRG.26574.3_2 - 4e-85 284.6 0.0 6.4e-85 283.9 0.0 1.3 1 0 0 1 1 1 1 Copine C2 PF00168.28 MSTRG.26574.3_2 - 6e-25 87.4 0.0 1.2e-12 47.8 0.1 2.4 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.7 MSTRG.26574.3_2 - 0.00023 21.2 0.0 0.0005 20.1 0.0 1.5 1 0 0 1 1 1 1 vWA found in TerF C terminus TAFH PF07531.12 MSTRG.28194.1_1 - 8.1e-22 76.9 0.1 1.1e-21 76.5 0.1 1.2 1 0 0 1 1 1 1 NHR1 homology to TAF TCP PF03634.11 MSTRG.28194.1_1 - 0.037 14.4 0.1 0.046 14.2 0.1 1.1 1 0 0 1 1 1 0 TCP family transcription factor SR-25 PF10500.7 MSTRG.28194.1_1 - 0.56 9.6 7.2 0.79 9.2 7.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Herpes_pp85 PF04637.10 MSTRG.28194.1_1 - 3.2 5.9 8.5 3.8 5.7 8.5 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Syntaphilin PF15290.4 MSTRG.28194.1_1 - 6 6.3 6.1 8.8 5.7 6.1 1.2 1 0 0 1 1 1 0 Golgi-localised syntaxin-1-binding clamp DUF3309 PF11752.6 MSTRG.28194.1_3 - 0.0058 16.5 0.1 0.01 15.7 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3309) ETRAMP PF09716.8 MSTRG.28194.1_3 - 0.23 11.4 0.0 0.28 11.1 0.0 1.2 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) PBC PF03792.11 MSTRG.3696.1_1 - 2.4e-89 298.0 0.1 4.2e-89 297.2 0.1 1.4 1 0 0 1 1 1 1 PBC domain Homeobox PF00046.27 MSTRG.3696.1_1 - 1.3e-19 69.6 0.7 2.6e-19 68.6 0.7 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 MSTRG.3696.1_1 - 1e-16 60.4 0.0 8e-16 57.5 0.0 2.4 2 0 0 2 2 2 1 Homeobox KN domain YdaS_antitoxin PF15943.3 MSTRG.3696.1_1 - 0.0056 16.4 0.0 0.014 15.1 0.0 1.6 1 0 0 1 1 1 1 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_3 PF01381.20 MSTRG.3696.1_1 - 0.062 13.2 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix VPS9 PF02204.16 MSTRG.2910.2_1 - 5.6e-30 103.5 0.0 2.8e-29 101.3 0.0 2.1 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain RasGAP PF00616.17 MSTRG.2910.2_1 - 4.1e-19 69.0 0.1 9.8e-19 67.7 0.1 1.7 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase zf-C2H2_4 PF13894.4 MSTRG.19553.1_1 - 3.2e-22 77.1 61.0 0.00073 20.0 1.3 7.3 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2 PF00096.24 MSTRG.19553.1_1 - 7.1e-21 73.3 66.9 0.004 17.4 0.8 7.3 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.19553.1_1 - 2.2e-17 62.5 63.8 1.6e-05 25.0 1.4 8.4 8 0 0 8 8 8 6 Zinc-finger double domain zf-C2H2_jaz PF12171.6 MSTRG.19553.1_1 - 1.6e-06 28.1 38.7 0.25 11.6 1.3 6.7 7 0 0 7 7 7 5 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 MSTRG.19553.1_1 - 1.6e-05 24.6 46.9 0.0015 18.3 0.1 7.5 7 0 0 7 7 7 3 C2H2-type zinc finger zf-C2H2_8 PF15909.3 MSTRG.19553.1_1 - 0.00013 22.1 30.4 0.0033 17.6 12.1 3.7 1 1 3 4 4 4 2 C2H2-type zinc ribbon zf-met PF12874.5 MSTRG.19553.1_1 - 0.0011 19.1 29.8 0.12 12.7 0.0 5.6 5 0 0 5 5 5 2 Zinc-finger of C2H2 type Acyltransf_C PF16076.3 MSTRG.19553.1_1 - 0.018 15.0 2.2 3.7 7.6 0.2 2.6 2 0 0 2 2 2 0 Acyltransferase C-terminus zf-C2H2_2 PF12756.5 MSTRG.19553.1_1 - 0.12 12.6 36.0 7.2 6.9 0.1 5.9 1 1 4 6 6 6 0 C2H2 type zinc-finger (2 copies) PyrI_C PF02748.13 MSTRG.19553.1_1 - 0.17 11.7 23.3 0.49 10.2 1.5 5.2 4 2 2 6 6 6 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain OSTMP1 PF09777.7 MSTRG.19553.1_1 - 0.31 10.3 9.3 0.11 11.7 4.1 2.0 1 1 1 2 2 2 0 Osteopetrosis-associated transmembrane protein 1 precursor DUF2321 PF10083.7 MSTRG.19553.1_1 - 2 7.9 6.4 8.4 5.9 0.8 3.0 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2321) HNH_5 PF14279.4 MSTRG.19553.1_1 - 3.5 7.4 17.3 11 5.8 0.1 5.0 3 2 1 4 4 4 0 HNH endonuclease zinc_ribbon_15 PF17032.3 MSTRG.19553.1_1 - 7.1 7.3 20.0 2.2 9.0 2.6 4.1 1 1 2 4 4 4 0 zinc-ribbon family zf-LITAF-like PF10601.7 MSTRG.19553.1_1 - 7.4 6.8 18.0 0.34 11.1 3.0 4.1 4 1 0 4 4 4 0 LITAF-like zinc ribbon domain ADK_lid PF05191.12 MSTRG.19553.1_1 - 9 6.3 17.1 24 4.9 1.2 4.3 3 1 0 3 3 3 0 Adenylate kinase, active site lid ORC6 PF05460.11 MSTRG.19553.1_3 - 1 8.4 6.6 1.4 7.9 6.6 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Syntaxin_2 PF14523.4 MSTRG.2137.1_2 - 0.0088 16.3 0.6 0.018 15.3 0.6 1.4 1 0 0 1 1 1 1 Syntaxin-like protein ASD1 PF08688.8 MSTRG.23972.1_3 - 1.3e-38 132.9 2.4 1.3e-38 132.9 2.4 3.5 4 0 0 4 4 4 1 Apx/Shroom domain ASD1 ASD2 PF08687.9 MSTRG.23972.1_3 - 5e-29 101.7 11.4 5e-29 101.7 11.4 2.6 3 0 0 3 3 3 1 Apx/Shroom domain ASD2 PDZ PF00595.22 MSTRG.23972.1_3 - 2.8e-08 33.9 0.0 8.4e-08 32.3 0.0 1.9 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.23972.1_3 - 0.026 14.7 0.0 0.13 12.4 0.0 2.1 2 0 0 2 2 2 0 PDZ domain HlyIII PF03006.18 MSTRG.19510.2_2 - 3.4e-16 59.5 18.6 5.8e-16 58.7 18.6 1.3 1 0 0 1 1 1 1 Haemolysin-III related Haemolytic PF01809.16 MSTRG.19510.2_2 - 0.018 14.8 0.3 0.035 13.8 0.3 1.4 1 0 0 1 1 1 0 Haemolytic domain Cytochrom_B561 PF03188.14 MSTRG.6037.2_3 - 1.3e-18 67.3 3.1 1.9e-18 66.8 2.8 1.5 1 1 0 1 1 1 1 Eukaryotic cytochrome b561 DUF2427 PF10348.7 MSTRG.6037.2_3 - 0.012 15.2 2.1 0.021 14.5 2.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2427) GXWXG PF14231.4 MSTRG.17542.1_1 - 0.13 12.2 0.1 12 6.0 0.0 2.1 2 0 0 2 2 2 0 GXWXG protein DUF1443 PF07280.9 MSTRG.17542.1_3 - 0.066 12.9 1.3 0.43 10.3 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1443) DDE_Tnp_4 PF13359.4 MSTRG.18222.1_3 - 9.4e-11 41.5 0.4 1.3e-10 41.1 0.4 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease PHD PF00628.27 MSTRG.12164.1_1 - 6.2e-12 45.1 8.0 1.4e-11 44.0 8.0 1.6 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.4 MSTRG.12164.1_1 - 4.8e-05 23.1 5.8 4.8e-05 23.1 5.8 2.0 1 1 1 2 2 2 1 Prokaryotic RING finger family 1 SMN PF06003.10 MSTRG.12164.1_1 - 0.0042 16.3 0.2 0.0062 15.7 0.2 1.2 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) DUF1325 PF07039.9 MSTRG.12164.1_1 - 0.014 15.4 0.0 0.069 13.1 0.0 2.0 1 1 1 2 2 2 0 SGF29 tudor-like domain zf-piccolo PF05715.11 MSTRG.12164.1_1 - 0.034 14.2 3.9 0.11 12.6 3.9 1.9 1 0 0 1 1 1 0 Piccolo Zn-finger zf-RING_2 PF13639.4 MSTRG.12164.1_1 - 0.061 13.5 6.7 0.19 11.9 6.7 1.9 1 0 0 1 1 1 0 Ring finger domain DUF4537 PF15057.4 MSTRG.12164.1_1 - 0.084 12.7 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) C1_1 PF00130.20 MSTRG.12164.1_1 - 1.2 8.9 8.5 0.29 10.9 3.5 2.3 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Cullin PF00888.20 MSTRG.22006.1_3 - 1.2e-200 668.1 18.0 1.2e-200 668.1 18.0 1.5 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.7 MSTRG.22006.1_3 - 2.5e-28 97.7 4.1 9.3e-28 95.9 3.0 2.4 2 0 0 2 2 2 1 Cullin protein neddylation domain SAM_1 PF00536.28 MSTRG.14815.1_1 - 0.014 15.7 0.0 0.026 14.8 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) COPR5 PF15340.4 MSTRG.10672.2_1 - 0.1 13.1 0.0 0.13 12.8 0.0 1.2 1 0 0 1 1 1 0 Cooperator of PRMT5 family GAIN PF16489.3 MSTRG.13376.1_2 - 7.7e-41 139.7 0.1 1.1e-40 139.2 0.1 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain 7tm_2 PF00002.22 MSTRG.13376.1_2 - 1.2e-30 106.4 9.6 1.9e-30 105.9 9.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.19 MSTRG.13376.1_2 - 1.4e-11 44.7 3.5 1.8e-11 44.4 1.9 2.1 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif DNA_RNApol_7kD PF03604.11 MSTRG.3444.1_3 - 2.7e-16 58.8 8.5 2.7e-16 58.8 8.5 1.5 2 0 0 2 2 2 1 DNA directed RNA polymerase, 7 kDa subunit A2L_zn_ribbon PF08792.8 MSTRG.3444.1_3 - 0.0051 16.4 1.0 0.0082 15.7 1.0 1.3 1 0 0 1 1 1 1 A2L zinc ribbon domain Cytochrome_C7 PF14522.4 MSTRG.3444.1_3 - 0.017 15.0 0.4 0.02 14.8 0.4 1.2 1 0 0 1 1 1 0 Cytochrome c7 and related cytochrome c DZR PF12773.5 MSTRG.3444.1_3 - 0.024 14.5 0.7 0.035 14.0 0.7 1.3 1 0 0 1 1 1 0 Double zinc ribbon MCM_OB PF17207.1 MSTRG.3444.1_3 - 0.029 14.1 0.4 0.034 13.9 0.4 1.1 1 0 0 1 1 1 0 MCM OB domain HypA PF01155.17 MSTRG.3444.1_3 - 0.063 13.2 0.2 0.082 12.8 0.2 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_13 PF09855.7 MSTRG.3444.1_3 - 0.096 12.7 0.4 0.17 11.9 0.0 1.6 2 0 0 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) DUF3694 PF12473.6 MSTRG.17262.1_1 - 2.7e-07 31.2 0.2 3.9e-07 30.7 0.2 1.3 1 0 0 1 1 1 1 Kinesin protein DUF3585 PF12130.6 MSTRG.17262.1_1 - 0.017 15.1 4.3 0.017 15.1 4.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3585) Mob_Pre PF01076.17 MSTRG.17262.1_1 - 0.034 13.8 0.4 0.053 13.2 0.4 1.2 1 0 0 1 1 1 0 Plasmid recombination enzyme PDZ PF00595.22 MSTRG.19182.1_3 - 0.00081 19.6 0.1 0.0012 19.1 0.1 1.2 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Phospho_p8 PF10195.7 MSTRG.2759.2_3 - 1.1e-22 80.1 2.5 1.6e-22 79.6 2.5 1.3 1 0 0 1 1 1 1 DNA-binding nuclear phosphoprotein p8 GTF2I PF02946.12 MSTRG.992.1_1 - 2.7e-28 97.6 0.0 4.5e-28 97.0 0.0 1.3 1 0 0 1 1 1 1 GTF2I-like repeat GTF2I PF02946.12 MSTRG.992.1_2 - 1.4e-27 95.4 0.0 2.3e-27 94.7 0.0 1.4 1 0 0 1 1 1 1 GTF2I-like repeat GTF2I PF02946.12 MSTRG.992.1_3 - 2.3e-62 206.8 0.2 4e-30 103.5 0.0 2.3 2 0 0 2 2 2 2 GTF2I-like repeat GTP_EFTU PF00009.25 MSTRG.23394.6_3 - 1.3e-46 158.5 0.0 2e-46 157.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.15 MSTRG.23394.6_3 - 3.1e-25 88.5 0.0 7.1e-25 87.4 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain HBS1_N PF08938.8 MSTRG.23394.6_3 - 2.4e-16 59.6 0.1 4.5e-16 58.8 0.1 1.4 1 0 0 1 1 1 1 HBS1 N-terminus GTP_EFTU_D2 PF03144.23 MSTRG.23394.6_3 - 1.3e-06 28.6 0.0 2.7e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 MSTRG.23394.6_3 - 1e-05 25.4 0.1 0.00032 20.6 0.1 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.4 MSTRG.23394.6_3 - 0.0037 17.4 0.0 0.0079 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain GTP_EFTU_D4 PF14578.4 MSTRG.23394.6_3 - 0.045 13.6 0.0 0.27 11.1 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu domain 4 cobW PF02492.17 MSTRG.23394.6_3 - 0.077 12.4 0.2 10 5.6 0.0 2.9 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain DUF1201 PF06716.9 MSTRG.13017.1_2 - 7 6.6 11.5 0.23 11.4 2.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1201) Glyco_hydro_18 PF00704.26 MSTRG.4491.1_1 - 3e-95 319.4 0.0 3.7e-95 319.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_14 PF01607.22 MSTRG.4491.1_1 - 3.9e-08 33.2 10.5 7.3e-08 32.3 10.5 1.5 1 0 0 1 1 1 1 Chitin binding Peritrophin-A domain LMF1 PF06762.12 MSTRG.19800.1_3 - 1.6e-141 472.1 17.8 2.1e-141 471.7 17.8 1.2 1 0 0 1 1 1 1 Lipase maturation factor Ustilago_mating PF05722.10 MSTRG.29124.1_1 - 0.014 14.8 0.0 0.016 14.6 0.0 1.1 1 0 0 1 1 1 0 Ustilago B locus mating-type protein PI-PLC-X PF00388.17 MSTRG.13607.1_3 - 4.7e-58 194.8 0.0 7.6e-58 194.1 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.17 MSTRG.13607.1_3 - 1.7e-38 131.4 0.1 1.6e-37 128.3 0.0 2.3 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.28 MSTRG.13607.1_3 - 6.1e-18 64.9 0.0 1.2e-17 63.9 0.0 1.4 1 0 0 1 1 1 1 C2 domain PH_12 PF16457.3 MSTRG.13607.1_3 - 7.1e-18 65.3 0.0 1.3e-17 64.4 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain EF-hand_like PF09279.9 MSTRG.13607.1_3 - 6e-16 58.6 0.2 1.3e-15 57.5 0.2 1.5 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like Mcp5_PH PF12814.5 MSTRG.13607.1_3 - 0.039 13.9 0.0 0.081 12.9 0.0 1.5 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology T2SSI PF02501.15 MSTRG.23307.2_1 - 0.049 13.7 0.1 0.069 13.2 0.1 1.2 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein I 2-oxoacid_dh PF00198.21 MSTRG.25262.2_2 - 1.4e-80 269.9 0.2 1.8e-80 269.6 0.2 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.20 MSTRG.25262.2_2 - 4.3e-23 80.8 0.5 7e-23 80.1 0.5 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.4 MSTRG.25262.2_2 - 0.0025 17.5 0.1 0.0062 16.2 0.1 1.7 1 0 0 1 1 1 1 Biotin-lipoyl like GCV_H PF01597.17 MSTRG.25262.2_2 - 0.0054 16.5 0.3 0.0097 15.7 0.3 1.4 1 0 0 1 1 1 1 Glycine cleavage H-protein HlyD_D23 PF16576.3 MSTRG.25262.2_2 - 0.04 13.0 0.0 0.079 12.0 0.0 1.5 1 0 0 1 1 1 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion TNRC6-PABC_bdg PF16608.3 MSTRG.431.4_2 - 3.7e-60 204.0 25.9 3.7e-60 204.0 25.9 6.9 7 1 0 8 8 8 1 TNRC6-PABC binding domain RRM_1 PF00076.20 MSTRG.431.4_2 - 0.0055 16.4 0.0 0.0099 15.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 MSTRG.431.4_2 - 0.0083 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif MAP65_ASE1 PF03999.10 MSTRG.431.4_2 - 3.2 6.2 11.3 5.6 5.4 11.3 1.3 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) HTH_32 PF13565.4 MSTRG.431.4_2 - 7.2 7.2 6.4 2.5 8.6 0.1 2.9 3 0 0 3 3 3 0 Homeodomain-like domain LUC7 PF03194.13 MSTRG.27912.1_3 - 2.7e-73 246.5 24.2 2.7e-73 246.5 24.2 2.3 2 1 0 2 2 2 1 LUC7 N_terminus FPP PF05911.9 MSTRG.1010.7_1 - 0.00078 17.7 15.2 0.00078 17.7 15.2 2.1 1 1 1 2 2 2 1 Filament-like plant protein, long coiled-coil TSC22 PF01166.16 MSTRG.1010.7_1 - 0.071 13.3 0.2 0.071 13.3 0.2 4.4 4 1 0 4 4 4 0 TSC-22/dip/bun family PKcGMP_CC PF16808.3 MSTRG.1010.7_1 - 5 6.9 14.1 9.2 6.1 2.0 3.6 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4094 PF13334.4 MSTRG.1010.7_1 - 7.1 7.0 13.3 5 7.5 5.0 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) PRKG1_interact PF15898.3 MSTRG.1010.7_1 - 7.9 7.3 26.8 32 5.4 18.8 3.9 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain GNT-I PF03071.13 MSTRG.19776.2_3 - 5.4e-159 529.5 0.1 1.7e-158 527.8 0.0 1.6 1 1 0 2 2 2 1 GNT-I family Glyco_tranf_2_3 PF13641.4 MSTRG.19776.2_3 - 0.044 13.6 0.1 0.11 12.2 0.1 1.6 1 1 0 1 1 1 0 Glycosyltransferase like family 2 TLD PF07534.14 MSTRG.24609.5_1 - 2.1e-40 138.0 0.3 3.1e-40 137.5 0.3 1.2 1 0 0 1 1 1 1 TLD Anticodon_1 PF08264.11 MSTRG.19777.1_2 - 1.8e-16 60.4 0.0 2.6e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA Val_tRNA-synt_C PF10458.7 MSTRG.19777.1_2 - 0.00064 19.8 0.2 0.001 19.2 0.2 1.3 1 0 0 1 1 1 1 Valyl tRNA synthetase tRNA binding arm Gar1 PF04410.12 MSTRG.19777.1_2 - 0.11 12.2 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Gar1/Naf1 RNA binding region FliT PF05400.11 MSTRG.19777.1_2 - 0.28 11.9 1.9 1.5 9.6 1.9 2.0 1 1 0 1 1 1 0 Flagellar protein FliT RRM_1 PF00076.20 MSTRG.19209.1_3 - 3.8e-14 52.1 0.0 6.4e-14 51.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.4 MSTRG.19209.1_3 - 5.3e-07 30.0 7.0 5.3e-07 30.0 7.0 3.4 3 1 0 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 FYTT PF07078.9 MSTRG.19209.1_3 - 0.00075 18.8 3.0 0.0011 18.4 1.7 1.7 1 1 1 2 2 2 1 Forty-two-three protein RRM_occluded PF16842.3 MSTRG.19209.1_3 - 0.0049 16.6 0.0 0.062 13.0 0.0 2.3 2 0 0 2 2 2 1 Occluded RNA-recognition motif zf-C2H2 PF00096.24 MSTRG.22167.1_3 - 9.7e-12 44.5 23.7 0.0003 20.9 0.9 4.0 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.22167.1_3 - 4.7e-11 42.5 29.4 2.1e-08 34.1 1.3 5.8 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.22167.1_3 - 6.9e-10 38.8 20.6 0.0009 19.7 0.6 4.1 4 0 0 4 4 4 3 C2H2-type zinc finger zf-H2C2_5 PF13909.4 MSTRG.22167.1_3 - 3.9e-08 32.8 1.2 3.9e-08 32.8 1.2 5.2 4 1 0 4 4 4 1 C2H2-type zinc-finger domain zf-Di19 PF05605.10 MSTRG.22167.1_3 - 8.7e-06 25.8 6.4 0.0019 18.3 2.8 3.2 2 1 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-Sec23_Sec24 PF04810.13 MSTRG.22167.1_3 - 0.0004 20.2 2.8 1.3 9.0 0.0 3.3 2 1 1 3 3 3 1 Sec23/Sec24 zinc finger PyrI_C PF02748.13 MSTRG.22167.1_3 - 0.00073 19.3 1.2 7.6 6.4 0.1 3.4 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain CpXC PF14353.4 MSTRG.22167.1_3 - 0.0012 18.8 0.3 0.22 11.4 0.2 2.7 1 1 1 2 2 2 1 CpXC protein zf-C2H2_2 PF12756.5 MSTRG.22167.1_3 - 0.0012 19.0 5.4 3.4 7.9 0.1 3.4 2 1 1 3 3 3 1 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.3 MSTRG.22167.1_3 - 0.0028 17.2 0.9 0.0028 17.2 0.9 3.6 4 0 0 4 4 4 1 zinc-finger C2H2-type zf-C2H2_9 PF16293.3 MSTRG.22167.1_3 - 0.028 14.1 0.8 15 5.4 0.0 3.4 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) zf-C2HE PF16278.3 MSTRG.22167.1_3 - 0.031 14.6 6.2 1.8 9.0 4.1 3.3 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger GAGA PF09237.9 MSTRG.22167.1_3 - 0.04 13.6 3.5 1.5 8.6 0.0 2.9 2 1 0 2 2 2 0 GAGA factor ARS2 PF04959.11 MSTRG.22167.1_3 - 0.084 13.1 0.5 0.35 11.1 0.0 2.0 2 0 0 2 2 2 0 Arsenite-resistance protein 2 zinc_ribbon_10 PF10058.7 MSTRG.22167.1_3 - 0.14 11.8 2.8 14 5.4 0.0 3.2 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-CHCC PF10276.7 MSTRG.22167.1_3 - 0.14 12.1 3.5 1.5 8.8 0.2 2.5 2 0 0 2 2 2 0 Zinc-finger domain NOA36 PF06524.10 MSTRG.22167.1_3 - 0.16 11.2 2.9 4.4 6.5 0.1 2.8 2 1 1 3 3 3 0 NOA36 protein Elf1 PF05129.11 MSTRG.22167.1_3 - 0.19 11.6 7.8 3.4 7.6 0.2 3.3 2 1 1 3 3 3 0 Transcription elongation factor Elf1 like zf-met PF12874.5 MSTRG.22167.1_3 - 0.3 11.4 8.2 2 8.8 0.2 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type DUF2225 PF09986.7 MSTRG.22167.1_3 - 0.32 10.6 4.3 4.4 6.8 0.0 3.0 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) Zn-ribbon_8 PF09723.8 MSTRG.22167.1_3 - 0.4 10.7 8.0 0.32 11.0 1.1 2.5 2 0 0 2 2 2 0 Zinc ribbon domain Zn_Tnp_IS1595 PF12760.5 MSTRG.22167.1_3 - 0.58 10.1 8.7 22 5.0 1.0 3.1 2 1 1 3 3 3 0 Transposase zinc-ribbon domain zf-AN1 PF01428.14 MSTRG.22167.1_3 - 0.58 10.2 8.1 15 5.7 0.2 3.3 3 0 0 3 3 3 0 AN1-like Zinc finger zinc_ribbon_4 PF13717.4 MSTRG.22167.1_3 - 0.72 9.7 3.9 39 4.1 1.1 3.1 2 1 0 2 2 2 0 zinc-ribbon domain zf-C2H2_jaz PF12171.6 MSTRG.22167.1_3 - 0.74 10.1 12.8 1.6 9.0 0.2 4.0 3 1 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 MSTRG.22167.1_3 - 1.1 9.2 19.9 1.1 9.1 0.5 4.6 4 1 0 4 4 4 0 C2H2-type zinc finger zinc_ribbon_9 PF14369.4 MSTRG.22167.1_3 - 1.1 9.5 5.8 26 5.1 0.1 3.5 3 0 0 3 3 3 0 zinc-ribbon zf-nanos PF05741.11 MSTRG.22167.1_3 - 1.2 9.3 4.6 48 4.2 0.2 3.4 3 0 0 3 3 3 0 Nanos RNA binding domain zf-ribbon_3 PF13248.4 MSTRG.22167.1_3 - 2.6 7.4 5.8 14 5.1 0.1 3.2 3 0 0 3 3 3 0 zinc-ribbon domain TFIIS_C PF01096.16 MSTRG.22167.1_3 - 3.9 7.3 6.4 39 4.1 0.3 3.3 3 0 0 3 3 3 0 Transcription factor S-II (TFIIS) AP_endonuc_2 PF01261.22 MSTRG.1715.2_1 - 4.6e-29 101.2 0.3 6.8e-29 100.7 0.3 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel DUF2229 PF09989.7 MSTRG.3030.1_2 - 0.019 14.5 1.0 0.022 14.3 1.0 1.1 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) LST1 PF05083.11 MSTRG.3030.1_2 - 0.1 12.8 4.9 0.2 11.8 4.7 1.7 1 1 0 1 1 1 0 LST-1 protein DUF342 PF03961.11 MSTRG.3030.1_2 - 0.85 8.0 5.9 1.1 7.7 5.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF1003 PF06210.9 MSTRG.3030.1_2 - 1.7 8.7 4.8 4.2 7.4 4.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1003) HLH PF00010.24 MSTRG.11801.2_3 - 2.8e-19 68.7 0.2 5.8e-19 67.7 0.2 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain LRR_8 PF13855.4 MSTRG.5153.1_2 - 1.4e-29 101.5 31.5 1.4e-07 31.0 0.3 8.5 5 2 2 8 8 8 7 Leucine rich repeat LRR_4 PF12799.5 MSTRG.5153.1_2 - 4.8e-23 80.6 33.7 0.00014 22.0 0.4 9.7 4 3 6 10 10 10 9 Leucine Rich repeats (2 copies) TIR PF01582.18 MSTRG.5153.1_2 - 3.8e-18 65.7 0.0 6.6e-18 65.0 0.0 1.3 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.4 MSTRG.5153.1_2 - 1.1e-11 44.8 0.0 2.5e-11 43.7 0.0 1.6 1 0 0 1 1 1 1 TIR domain LRR_6 PF13516.4 MSTRG.5153.1_2 - 2.5e-09 36.3 11.9 0.41 10.7 0.3 8.3 8 0 0 8 8 8 3 Leucine Rich repeat LRR_9 PF14580.4 MSTRG.5153.1_2 - 5.8e-07 29.0 3.6 0.018 14.4 0.2 3.7 2 1 0 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.31 MSTRG.5153.1_2 - 0.0039 17.3 34.5 5.6 7.7 0.0 10.6 11 0 0 11 11 11 1 Leucine Rich Repeat PrgI PF12666.5 MSTRG.5153.1_2 - 0.043 14.4 0.4 0.11 13.0 0.1 1.9 2 0 0 2 2 2 0 PrgI family protein PigN PF04987.12 MSTRG.7115.1_2 - 3.5e-137 457.9 39.1 7.3e-137 456.8 39.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.20 MSTRG.7115.1_2 - 1e-13 51.5 0.8 4.6e-13 49.4 0.8 1.9 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.21 MSTRG.7115.1_2 - 2.1e-05 23.9 0.1 6.7e-05 22.3 0.1 1.7 2 0 0 2 2 2 1 Sulfatase Kinesin PF00225.21 MSTRG.26410.1_1 - 4.1e-96 321.7 2.4 4.2e-96 321.6 0.0 2.4 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.3 MSTRG.26410.1_1 - 3.7e-15 56.0 0.0 1.4e-12 47.7 0.0 2.9 2 0 0 2 2 2 2 Microtubule binding GspH PF12019.6 MSTRG.26410.1_1 - 0.024 14.9 0.2 0.25 11.7 0.1 2.7 2 0 0 2 2 2 0 Type II transport protein GspH FOLN PF09289.8 MSTRG.26410.1_1 - 0.045 13.8 0.5 0.089 12.9 0.5 1.5 1 0 0 1 1 1 0 Follistatin/Osteonectin-like EGF domain NPV_P10 PF05531.10 MSTRG.26410.1_1 - 9.2 6.7 45.5 0.48 10.8 1.5 7.9 7 2 1 8 8 8 0 Nucleopolyhedrovirus P10 protein DUF3715 PF12509.6 MSTRG.6606.2_3 - 9.1e-46 155.4 0.0 2.5e-45 154.0 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3715) Sema PF01403.17 MSTRG.420.1_3 - 2.3e-137 458.1 0.0 3.1e-137 457.7 0.0 1.2 1 0 0 1 1 1 1 Sema domain PSI PF01437.23 MSTRG.420.1_3 - 0.00021 21.6 6.0 0.0007 19.9 6.0 1.9 1 0 0 1 1 1 1 Plexin repeat Ig_3 PF13927.4 MSTRG.420.1_3 - 0.0075 16.7 0.0 0.018 15.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain PQQ_3 PF13570.4 MSTRG.420.1_3 - 0.0099 16.2 3.3 1.6 9.2 0.1 4.0 4 0 0 4 4 4 1 PQQ-like domain Acyl-CoA_dh_N PF02771.14 MSTRG.21760.1_2 - 6.4e-29 100.8 0.0 1.2e-28 99.9 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.22 MSTRG.21760.1_2 - 2e-27 96.1 0.6 3e-27 95.5 0.6 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.17 MSTRG.21760.1_2 - 8.7e-19 67.4 0.0 1.4e-18 66.7 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.9 MSTRG.21760.1_2 - 1.7e-05 24.9 0.2 4.7e-05 23.5 0.2 1.7 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Cadherin PF00028.15 MSTRG.1057.1_2 - 6e-71 234.8 9.2 3.6e-18 65.6 0.1 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.15 MSTRG.1057.1_2 - 4e-53 179.1 0.6 8.4e-53 178.1 0.5 1.7 2 0 0 2 2 2 1 Cadherin cytoplasmic region Cadherin_3 PF16184.3 MSTRG.1057.1_2 - 1.6e-06 28.0 4.6 0.77 9.7 0.1 4.7 5 0 0 5 5 5 3 Cadherin-like Cadherin_2 PF08266.10 MSTRG.1057.1_2 - 0.00035 20.2 0.0 2.1 8.1 0.0 3.6 3 0 0 3 3 3 2 Cadherin-like EURL PF06937.9 MSTRG.22766.1_3 - 1.1e-120 402.3 3.3 1.5e-120 401.8 3.3 1.2 1 0 0 1 1 1 1 EURL protein MFS_1 PF07690.14 MSTRG.16987.1_2 - 3.8e-16 58.8 24.7 3.8e-16 58.8 24.7 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily SVWC PF15430.4 MSTRG.16316.1_1 - 0.17 12.1 0.0 0.24 11.5 0.0 1.2 1 0 0 1 1 1 0 Single domain von Willebrand factor type C DSPc PF00782.18 MSTRG.2046.1_1 - 3.9e-08 33.1 0.0 5.7e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PLAT PF01477.21 MSTRG.12015.1_2 - 0.0002 21.8 0.0 0.00023 21.6 0.0 1.1 1 0 0 1 1 1 1 PLAT/LH2 domain IMPDH PF00478.23 MSTRG.25941.1_3 - 1.2e-79 267.7 0.7 1.8e-79 267.1 0.7 1.2 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.16 MSTRG.25941.1_3 - 0.00013 21.0 0.3 0.0002 20.4 0.3 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase dCache_3 PF14827.4 MSTRG.25941.1_3 - 0.01 15.4 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 0 Double sensory domain of two-component sensor kinase OLF PF02191.14 MSTRG.16810.2_1 - 2.1e-83 279.5 0.7 2.6e-83 279.2 0.7 1.1 1 0 0 1 1 1 1 Olfactomedin-like domain Noelin-1 PF12308.6 MSTRG.16810.2_1 - 9.4e-12 44.7 1.3 2e-10 40.4 0.6 2.6 3 0 0 3 3 3 1 Neurogenesis glycoprotein DHC_N2 PF08393.11 MSTRG.16810.2_1 - 0.0083 15.1 0.1 0.012 14.7 0.1 1.1 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 K-box PF01486.15 MSTRG.16810.2_1 - 0.016 15.3 1.6 0.036 14.1 1.6 1.5 1 0 0 1 1 1 0 K-box region HOOK PF05622.10 MSTRG.16810.2_1 - 0.028 12.5 2.6 0.037 12.1 2.6 1.1 1 0 0 1 1 1 0 HOOK protein HSBP1 PF06825.10 MSTRG.16810.2_1 - 0.077 12.8 0.1 0.52 10.1 0.0 2.3 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Laminin_II PF06009.10 MSTRG.16810.2_1 - 0.14 12.0 0.3 0.94 9.4 0.3 2.0 2 0 0 2 2 2 0 Laminin Domain II IncA PF04156.12 MSTRG.16810.2_1 - 0.19 11.3 2.1 0.3 10.7 2.1 1.3 1 0 0 1 1 1 0 IncA protein CLZ PF16526.3 MSTRG.16810.2_1 - 0.46 10.7 2.6 8.6 6.7 0.1 3.3 2 2 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels CENP-F_leu_zip PF10473.7 MSTRG.16810.2_1 - 0.65 9.9 4.7 1 9.3 3.4 1.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FUSC PF04632.10 MSTRG.16810.2_1 - 1.4 7.3 3.8 1.7 6.9 3.8 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family ABC_tran_CTD PF16326.3 MSTRG.16810.2_1 - 3.3 7.9 4.7 1e+02 3.1 3.5 3.0 1 1 1 2 2 2 0 ABC transporter C-terminal domain Peptidase_S8 PF00082.20 MSTRG.13718.1_2 - 1.7e-49 168.6 2.6 2.3e-49 168.1 2.6 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.18 MSTRG.13718.1_2 - 2.8e-30 104.1 0.4 4.8e-30 103.3 0.4 1.4 1 0 0 1 1 1 1 Proprotein convertase P-domain Proho_convert PF12177.6 MSTRG.13718.1_2 - 5.5e-23 80.5 2.5 2e-22 78.7 2.5 2.1 1 0 0 1 1 1 1 Prohormone convertase enzyme S8_pro-domain PF16470.3 MSTRG.13718.1_2 - 3.9e-22 78.7 2.1 8.9e-22 77.6 2.1 1.7 1 0 0 1 1 1 1 Peptidase S8 pro-domain THRAP3_BCLAF1 PF15440.4 MSTRG.15367.3_2 - 3.9e-70 237.6 71.5 5.1e-68 230.6 34.8 3.8 2 1 1 3 3 3 2 THRAP3/BCLAF1 family Btz PF09405.8 MSTRG.15367.3_2 - 1.5e-05 25.2 6.3 1.5e-05 25.2 6.3 4.7 5 1 0 5 5 5 1 CASC3/Barentsz eIF4AIII binding THRAP3_BCLAF1 PF15440.4 MSTRG.15367.3_3 - 5.4e-13 48.7 14.1 5.4e-13 48.7 14.1 2.8 4 0 0 4 4 4 1 THRAP3/BCLAF1 family GST_N_2 PF13409.4 MSTRG.10342.2_3 - 2.7e-05 24.3 0.0 4.8e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.4 MSTRG.10342.2_3 - 0.00035 20.3 0.0 0.00077 19.2 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 MSTRG.10342.2_3 - 0.00071 19.8 0.0 0.0013 19.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 MSTRG.10342.2_3 - 0.014 15.4 0.0 0.036 14.2 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.22 MSTRG.10342.2_3 - 0.015 15.3 0.0 0.024 14.7 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin V-set PF07686.15 MSTRG.10340.1_2 - 1e-13 51.2 0.0 1.8e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 MSTRG.10340.1_2 - 9.5e-05 22.4 0.0 0.0068 16.4 0.0 2.4 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.10340.1_2 - 0.004 17.6 0.0 0.0096 16.4 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 MSTRG.10340.1_2 - 0.015 15.2 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.10340.1_2 - 0.018 15.2 0.0 0.078 13.2 0.0 1.9 1 1 0 1 1 1 0 Immunoglobulin domain PAXNEB PF05625.9 MSTRG.23188.2_2 - 2.3e-29 102.6 0.0 3e-29 102.2 0.0 1.1 1 0 0 1 1 1 1 PAXNEB protein LRR_4 PF12799.5 MSTRG.11113.6_3 - 9.4e-22 76.5 32.2 1.2e-07 31.7 3.1 3.4 1 1 4 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 MSTRG.11113.6_3 - 4.7e-18 64.6 14.5 1.3e-09 37.5 6.1 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.31 MSTRG.11113.6_3 - 9.9e-10 37.4 8.2 0.74 10.4 0.1 5.2 5 0 0 5 5 5 4 Leucine Rich Repeat LRR_6 PF13516.4 MSTRG.11113.6_3 - 1.3e-06 27.9 14.1 1.5 8.9 0.0 5.2 5 0 0 5 5 5 5 Leucine Rich repeat RsmF_methylt_CI PF17126.3 MSTRG.11113.6_3 - 0.0085 16.0 0.1 6.7 6.7 0.0 3.1 1 1 2 3 3 3 2 RsmF rRNA methyltransferase first C-terminal domain DUF240 PF03086.12 MSTRG.11113.6_3 - 0.13 12.1 1.5 0.91 9.3 0.2 2.1 1 1 1 2 2 2 0 MG032/MG096/MG288 family 2 CF222 PF15661.3 MSTRG.17907.1_3 - 0.046 12.4 0.2 0.062 12.0 0.2 1.0 1 0 0 1 1 1 0 C6orf222, uncharacterised family C1_1 PF00130.20 MSTRG.6267.2_2 - 0.041 13.6 6.2 0.1 12.4 6.2 1.7 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_1 PF00130.20 MSTRG.6267.2_3 - 5.6e-11 42.0 15.0 5.6e-11 42.0 15.0 2.1 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) UPF0167 PF03691.12 MSTRG.6267.2_3 - 0.021 14.5 0.6 0.021 14.5 0.6 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0167) DUF3262 PF11660.6 MSTRG.28222.1_1 - 0.031 14.5 0.1 0.041 14.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3262) SURF4 PF02077.13 MSTRG.12012.2_3 - 2.3e-120 401.0 5.5 3.1e-120 400.6 5.5 1.1 1 0 0 1 1 1 1 SURF4 family DoxX PF07681.10 MSTRG.12012.2_3 - 0.0064 16.9 12.3 0.15 12.5 0.3 2.9 2 1 1 3 3 3 2 DoxX WH1 PF00568.21 MSTRG.17467.2_2 - 8.5e-35 118.9 0.6 1.6e-34 118.0 0.6 1.4 1 0 0 1 1 1 1 WH1 domain Macoilin PF09726.7 MSTRG.17467.2_2 - 0.0041 15.6 19.8 0.0059 15.1 19.8 1.1 1 0 0 1 1 1 1 Transmembrane protein DMPK_coil PF08826.8 MSTRG.17467.2_2 - 0.0058 16.6 0.2 0.0058 16.6 0.2 3.5 2 1 1 3 3 3 1 DMPK coiled coil domain like MAD PF05557.11 MSTRG.17467.2_2 - 0.014 13.6 27.3 0.022 13.0 27.3 1.2 1 0 0 1 1 1 0 Mitotic checkpoint protein Nnf1 PF03980.12 MSTRG.17467.2_2 - 0.095 13.0 19.2 1.9 8.8 2.9 3.7 3 0 0 3 3 3 0 Nnf1 GAS PF13851.4 MSTRG.17467.2_2 - 0.13 11.5 32.4 0.055 12.7 12.7 2.8 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding TSC22 PF01166.16 MSTRG.17467.2_2 - 0.13 12.4 0.1 0.13 12.4 0.1 3.7 2 2 1 3 3 3 0 TSC-22/dip/bun family DUF4201 PF13870.4 MSTRG.17467.2_2 - 0.29 10.6 28.4 0.2 11.2 7.8 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4201) FlaC_arch PF05377.9 MSTRG.17467.2_2 - 0.34 11.2 13.1 6.2 7.2 0.7 4.5 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) BST2 PF16716.3 MSTRG.17467.2_2 - 0.42 11.1 33.6 0.099 13.1 9.9 4.0 2 1 2 4 4 4 0 Bone marrow stromal antigen 2 HAP1_N PF04849.11 MSTRG.17467.2_2 - 0.93 8.5 29.6 1.9 7.5 29.6 1.5 1 1 0 1 1 1 0 HAP1 N-terminal conserved region VGPC1_C PF16799.3 MSTRG.17467.2_2 - 1.3 8.9 11.7 0.98 9.3 4.1 2.8 2 1 1 3 3 3 0 C-terminal membrane-localisation domain of ion-channel, VCN1 T3SSipB PF16535.3 MSTRG.17467.2_2 - 6.6 7.1 18.2 0.69 10.3 10.7 2.2 2 0 0 2 2 2 0 Type III cell invasion protein SipB Rootletin PF15035.4 MSTRG.17467.2_2 - 8.3 6.3 29.8 0.51 10.3 10.7 2.6 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion S1 PF00575.21 MSTRG.19047.4_1 - 6.4e-39 132.0 3.7 4.7e-12 45.9 0.1 5.9 6 0 0 6 6 6 5 S1 RNA binding domain A_deamin PF02137.16 MSTRG.4574.1_2 - 6e-101 338.0 0.0 1.1e-100 337.1 0.0 1.4 1 1 0 1 1 1 1 Adenosine-deaminase (editase) domain LSM PF01423.20 MSTRG.26579.2_1 - 8.5e-20 70.1 0.2 1.5e-19 69.3 0.2 1.4 1 0 0 1 1 1 1 LSM domain MAGE PF01454.17 MSTRG.11523.2_3 - 5.6e-25 88.2 0.0 8.9e-24 84.2 0.0 2.1 1 1 0 1 1 1 1 MAGE family DUF4294 PF14127.4 MSTRG.11523.2_3 - 0.014 15.2 0.1 0.022 14.5 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4294) TAF6_C PF07571.11 MSTRG.11523.2_3 - 0.03 14.5 0.1 0.087 13.1 0.0 1.8 2 0 0 2 2 2 0 TAF6 C-terminal HEAT repeat domain Period_C PF12114.6 MSTRG.13850.1_1 - 9.1e-63 211.3 6.8 9.1e-63 211.3 6.8 4.1 5 0 0 5 5 5 1 Period protein 2/3C-terminal region PAS_3 PF08447.10 MSTRG.13850.1_1 - 8e-15 54.8 0.0 6.7e-14 51.8 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS_11 PF14598.4 MSTRG.13850.1_1 - 3e-10 40.1 0.0 9.7e-10 38.4 0.0 1.9 1 0 0 1 1 1 1 PAS domain PAS PF00989.23 MSTRG.13850.1_1 - 2.1e-09 37.2 0.0 2.6e-07 30.5 0.0 2.7 2 0 0 2 2 2 1 PAS fold DcpS_C PF11969.6 MSTRG.23083.1_1 - 9e-06 26.0 0.1 1.6e-05 25.2 0.1 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DcpS_C PF11969.6 MSTRG.23083.1_2 - 6e-14 52.4 0.1 6e-14 52.4 0.1 1.7 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.21 MSTRG.23083.1_2 - 8.5e-05 23.1 0.1 8.5e-05 23.1 0.1 1.5 2 0 0 2 2 2 1 HIT domain DPPIV_N PF00930.19 MSTRG.20740.1_3 - 1.3e-78 264.2 0.0 1.4e-78 264.0 0.0 1.0 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region PD40 PF07676.10 MSTRG.20740.1_3 - 8.5e-05 22.3 0.2 0.56 10.1 0.0 3.2 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat MVL PF12151.6 MSTRG.26165.1_3 - 0.015 15.0 6.2 0.12 12.1 0.5 3.5 3 0 0 3 3 3 0 Mannan-binding protein Gastrin PF00918.15 MSTRG.13468.1_1 - 4.4e-35 121.2 0.0 6e-35 120.8 0.0 1.2 1 0 0 1 1 1 1 Gastrin/cholecystokinin family BP28CT PF08146.10 MSTRG.10121.6_3 - 1.8e-17 63.6 2.0 2.8e-17 62.9 0.2 2.1 2 1 0 2 2 2 1 BP28CT (NUC211) domain HEAT_EZ PF13513.4 MSTRG.10121.6_3 - 0.006 16.9 0.1 0.046 14.1 0.0 2.3 2 0 0 2 2 2 1 HEAT-like repeat Vac14_Fab1_bd PF12755.5 MSTRG.10121.6_3 - 0.043 14.3 0.1 0.1 13.0 0.1 1.6 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region Pox_RNA_Pol_19 PF05320.10 MSTRG.10121.6_3 - 0.11 12.3 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit Hemopexin PF00045.17 MSTRG.24084.1_2 - 2.4e-38 129.7 13.5 1.5e-13 50.3 0.3 5.4 5 0 0 5 5 5 5 Hemopexin Somatomedin_B PF01033.15 MSTRG.24084.1_2 - 8.7e-10 38.7 13.3 1.5e-09 37.9 13.3 1.4 1 0 0 1 1 1 1 Somatomedin B domain ANAPC10 PF03256.14 MSTRG.8199.1_3 - 1.5e-78 262.6 0.1 2.1e-78 262.1 0.1 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.23 MSTRG.8199.1_3 - 0.0015 18.5 0.0 0.0023 17.9 0.0 1.2 1 0 0 1 1 1 1 F5/8 type C domain PITH PF06201.11 MSTRG.8199.1_3 - 0.091 12.8 0.0 0.35 11.0 0.0 1.8 1 1 0 1 1 1 0 PITH domain MBT PF02820.16 MSTRG.17933.2_1 - 6.2e-25 87.2 0.3 1.1e-24 86.5 0.3 1.3 1 0 0 1 1 1 1 mbt repeat zf-C2HC PF01530.16 MSTRG.17933.2_1 - 5.7e-11 42.3 10.1 1.7e-10 40.8 10.1 1.9 1 0 0 1 1 1 1 Zinc finger, C2HC type SAM_1 PF00536.28 MSTRG.17933.2_2 - 1.5e-13 50.8 0.0 2.4e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) MBT PF02820.16 MSTRG.17933.2_2 - 1.5e-07 31.6 0.0 2.7e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 mbt repeat SAM_2 PF07647.15 MSTRG.17933.2_2 - 9.5e-05 22.3 0.0 0.00014 21.7 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 MSTRG.17933.2_2 - 0.059 13.2 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Presenilin PF01080.15 MSTRG.17933.2_2 - 2.6 6.6 4.6 3.7 6.0 4.6 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.12 MSTRG.17933.2_2 - 4.6 5.3 8.2 7 4.7 8.2 1.1 1 0 0 1 1 1 0 CDC45-like protein MBT PF02820.16 MSTRG.17933.2_3 - 1.9e-40 136.9 0.7 1.2e-23 83.0 0.0 2.4 2 0 0 2 2 2 2 mbt repeat Phospho_p8 PF10195.7 MSTRG.17933.2_3 - 1.2 9.6 5.2 3.1 8.2 5.2 1.6 1 0 0 1 1 1 0 DNA-binding nuclear phosphoprotein p8 EF-hand_1 PF00036.30 MSTRG.12607.1_1 - 2.5e-06 26.5 0.2 6.6e-06 25.2 0.0 1.7 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.4 MSTRG.12607.1_1 - 1.2e-05 24.5 0.0 2.5e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.4 MSTRG.12607.1_1 - 0.0037 17.6 0.1 0.0057 17.0 0.1 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.4 MSTRG.12607.1_1 - 0.0039 16.8 0.2 0.0067 16.0 0.2 1.5 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.12607.1_1 - 0.0071 16.1 0.1 0.03 14.1 0.0 2.1 2 1 1 3 3 3 1 EF-hand domain ArsR PF09824.7 MSTRG.12607.1_1 - 0.084 12.3 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 ArsR transcriptional regulator SNF2_N PF00176.21 MSTRG.1228.1_3 - 3.7e-62 209.9 0.3 3.7e-62 209.9 0.3 2.0 2 1 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.29 MSTRG.1228.1_3 - 2.8e-21 75.8 0.6 8.5e-20 71.1 0.0 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.1228.1_3 - 4.1e-09 36.5 1.0 1.6e-07 31.3 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.27 MSTRG.1228.1_3 - 3.3e-05 23.6 0.0 8e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Shugoshin_C PF07557.9 MSTRG.1228.1_3 - 0.0088 15.7 0.2 0.018 14.7 0.2 1.5 1 0 0 1 1 1 1 Shugoshin C terminus Sec20 PF03908.11 MSTRG.1228.1_3 - 2 8.3 5.8 4.2 7.2 4.6 2.1 2 0 0 2 2 2 0 Sec20 Sec6 PF06046.11 MSTRG.27067.3_2 - 3.9e-62 210.3 0.0 5e-62 209.9 0.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec6 Calc_CGRP_IAPP PF00214.17 MSTRG.27067.3_2 - 0.0004 20.6 0.0 0.0012 19.1 0.0 1.8 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family BTG PF07742.10 MSTRG.27067.3_2 - 0.044 13.5 0.0 14 5.4 0.0 2.5 2 0 0 2 2 2 0 BTG family PRD PF00874.18 MSTRG.27067.3_2 - 0.12 12.6 0.4 1.4 9.1 0.1 2.5 2 0 0 2 2 2 0 PRD domain BCCT PF02028.15 MSTRG.27067.3_3 - 1.5 7.0 5.0 2.2 6.5 5.0 1.1 1 0 0 1 1 1 0 BCCT, betaine/carnitine/choline family transporter RimK PF08443.9 MSTRG.18203.1_1 - 1.2e-37 129.2 0.0 1.7e-37 128.7 0.0 1.2 1 0 0 1 1 1 1 RimK-like ATP-grasp domain GSH-S_ATP PF02955.14 MSTRG.18203.1_1 - 1.3e-11 44.1 0.0 2.7e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATP-grasp_3 PF02655.12 MSTRG.18203.1_1 - 8.3e-05 22.5 0.0 0.00013 22.0 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.4 MSTRG.18203.1_1 - 0.00062 19.0 1.0 0.21 10.7 0.2 3.3 1 1 1 2 2 2 2 Sugar-transfer associated ATP-grasp ATPgrasp_Ter PF15632.4 MSTRG.18203.1_1 - 0.00084 18.0 0.0 0.0014 17.3 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon CPSase_L_D2 PF02786.15 MSTRG.18203.1_1 - 0.0062 15.9 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain DUF1980 PF09323.8 MSTRG.18203.1_1 - 0.018 14.8 0.7 0.059 13.1 0.7 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) ATP-grasp PF02222.20 MSTRG.18203.1_1 - 0.049 13.1 0.0 0.078 12.4 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain WD40 PF00400.30 MSTRG.19273.1_1 - 2.3e-05 24.9 0.8 4.1e-05 24.1 0.8 1.4 1 0 0 1 1 1 1 WD domain, G-beta repeat RRM_1 PF00076.20 MSTRG.13668.2_1 - 2.6e-39 132.7 0.0 2.1e-23 81.8 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.4 MSTRG.13668.2_1 - 3.7e-28 98.3 0.2 3.7e-28 98.3 0.2 2.0 2 0 0 2 2 2 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.3 MSTRG.13668.2_1 - 0.0009 18.9 0.0 0.032 13.9 0.0 3.0 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_5 PF13893.4 MSTRG.13668.2_1 - 0.017 14.6 0.0 0.31 10.5 0.0 2.3 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.13668.2_1 - 0.11 12.5 0.0 0.48 10.4 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif Apt1 PF10351.7 MSTRG.13668.2_1 - 0.9 8.2 10.0 1.3 7.7 10.0 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain MIP-T3 PF10243.7 MSTRG.13668.2_1 - 1.6 7.2 28.2 2.5 6.6 28.2 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 SRP-alpha_N PF04086.11 MSTRG.13668.2_1 - 5.1 6.8 17.5 7.7 6.2 17.5 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal ABC_membrane_2 PF06472.13 MSTRG.11730.1_1 - 1e-105 353.0 5.9 1.4e-105 352.6 5.9 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.25 MSTRG.11730.1_1 - 1.2e-16 61.3 0.0 2e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.4 MSTRG.11730.1_1 - 0.00031 20.5 0.0 0.0005 19.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.4 MSTRG.11730.1_1 - 0.01 16.2 0.5 0.025 14.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.4 MSTRG.11730.1_1 - 0.037 13.6 0.0 0.083 12.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Adeno_IVa2 PF02456.13 MSTRG.11730.1_1 - 0.054 12.1 0.1 0.096 11.3 0.1 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein Rad17 PF03215.13 MSTRG.11730.1_1 - 0.086 11.6 0.0 0.13 11.0 0.0 1.1 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein SMC_N PF02463.17 MSTRG.11730.1_1 - 0.19 11.0 0.1 0.65 9.3 0.1 1.7 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Laminin_EGF PF00053.22 MSTRG.3122.1_3 - 2e-112 367.1 260.6 1.4e-11 44.2 13.9 13.8 12 1 1 13 13 13 13 Laminin EGF domain Laminin_N PF00055.15 MSTRG.3122.1_3 - 1.3e-79 266.9 0.1 6.5e-79 264.7 0.1 2.4 1 0 0 1 1 1 1 Laminin N-terminal (Domain VI) APG6 PF04111.10 MSTRG.3122.1_3 - 0.00074 18.9 1.1 0.00074 18.9 1.1 4.2 3 1 1 4 4 4 1 Autophagy protein Apg6 Laminin_II PF06009.10 MSTRG.3122.1_3 - 0.0029 17.5 48.0 0.056 13.3 2.6 5.1 4 1 1 5 5 5 4 Laminin Domain II F5_F8_type_C PF00754.23 MSTRG.3122.1_3 - 0.004 17.1 0.0 0.0092 16.0 0.0 1.5 1 0 0 1 1 1 1 F5/8 type C domain EzrA PF06160.10 MSTRG.3122.1_3 - 0.092 10.8 47.6 0.0049 15.0 12.7 4.2 2 1 0 4 4 4 0 Septation ring formation regulator, EzrA DUF412 PF04217.11 MSTRG.3122.1_3 - 0.98 9.2 3.9 2.2 8.0 2.0 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF412 GAS PF13851.4 MSTRG.3122.1_3 - 2.7 7.2 55.6 0.02 14.1 1.2 4.6 3 1 1 4 4 4 0 Growth-arrest specific micro-tubule binding DUF812 PF05667.9 MSTRG.3122.1_3 - 5.1 5.7 52.9 1.1 7.9 30.6 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF812) Alanine_zipper PF11839.6 MSTRG.3122.1_3 - 9.3 6.5 65.7 0.032 14.3 10.0 6.1 3 2 2 5 5 5 0 Alanine-zipper, major outer membrane lipoprotein Reo_sigmaC PF04582.10 MSTRG.3122.1_3 - 9.9 5.3 21.9 1.1 8.5 1.4 3.8 2 1 3 5 5 5 0 Reovirus sigma C capsid protein HRG PF16954.3 MSTRG.574.1_2 - 2.2e-23 82.3 19.7 1.2e-15 57.5 3.0 3.1 3 0 0 3 3 3 2 Haem-transporter, endosomal/lysosomal, haem-responsive gene GRAM PF02893.18 MSTRG.9257.2_2 - 1.5e-19 69.8 0.6 3e-19 68.8 0.6 1.5 1 0 0 1 1 1 1 GRAM domain DUF1494 PF07379.9 MSTRG.9257.2_2 - 0.0097 15.6 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1494) Reovirus_cap PF00979.15 MSTRG.9257.2_2 - 0.029 13.4 0.0 0.043 12.9 0.0 1.2 1 0 0 1 1 1 0 Reovirus outer capsid protein, Sigma 3 F-box PF00646.31 MSTRG.16063.1_2 - 4.7e-11 42.1 0.1 4.7e-11 42.1 0.1 3.0 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.5 MSTRG.16063.1_2 - 2.1e-10 40.2 1.4 2.1e-10 40.2 1.4 2.8 3 0 0 3 3 3 1 F-box-like THAP PF05485.10 MSTRG.19808.1_2 - 1.5e-16 61.0 6.5 1.5e-16 61.0 6.5 2.1 2 0 0 2 2 2 1 THAP domain ADIP PF11559.6 MSTRG.19808.1_2 - 0.00026 21.0 6.6 0.00039 20.4 6.6 1.2 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding PI3K_P85_iSH2 PF16454.3 MSTRG.19808.1_2 - 0.0018 17.7 0.1 0.0026 17.2 0.1 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain CENP-Q PF13094.4 MSTRG.19808.1_2 - 0.0025 17.9 0.1 0.0035 17.4 0.1 1.2 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit IncA PF04156.12 MSTRG.19808.1_2 - 0.0062 16.2 0.3 0.0088 15.7 0.3 1.1 1 0 0 1 1 1 1 IncA protein Tropomyosin_1 PF12718.5 MSTRG.19808.1_2 - 0.0082 16.1 2.7 0.014 15.4 2.7 1.2 1 0 0 1 1 1 1 Tropomyosin like Sulfatase_C PF14707.4 MSTRG.19808.1_2 - 0.016 15.8 2.9 0.26 11.8 0.1 2.5 2 0 0 2 2 2 0 C-terminal region of aryl-sulfatase MPS2 PF17060.3 MSTRG.19808.1_2 - 0.13 11.4 0.7 0.23 10.5 0.7 1.3 1 0 0 1 1 1 0 Monopolar spindle protein 2 DUF4140 PF13600.4 MSTRG.19808.1_2 - 0.15 12.4 0.4 0.29 11.5 0.4 1.4 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) GrpE PF01025.17 MSTRG.19808.1_2 - 0.62 9.6 3.3 0.99 8.9 3.3 1.2 1 0 0 1 1 1 0 GrpE SlyX PF04102.10 MSTRG.19808.1_2 - 1.3 9.5 7.7 4 8.0 7.7 1.6 1 1 0 1 1 1 0 SlyX Guanylate_kin PF00625.19 MSTRG.5590.1_1 - 1.9e-48 164.4 0.2 2.2e-47 161.0 0.2 2.1 1 1 0 1 1 1 1 Guanylate kinase SH3_1 PF00018.26 MSTRG.5590.1_1 - 9.7e-06 25.0 0.3 4.9e-05 22.7 0.3 2.1 1 1 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.5590.1_1 - 1.5e-05 24.5 0.0 2.8e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 MSTRG.5590.1_1 - 0.13 12.0 0.0 0.29 10.9 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain DNA_pol_alpha_N PF12254.6 MSTRG.5590.1_1 - 0.29 11.1 1.6 0.69 9.9 1.6 1.6 1 0 0 1 1 1 0 DNA polymerase alpha subunit p180 N terminal IML1 PF12257.6 MSTRG.12904.1_1 - 6.8e-12 45.0 0.1 1.1e-11 44.3 0.1 1.3 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 CDKN3 PF05706.10 MSTRG.8949.1_1 - 9.2e-64 214.0 0.1 2.6e-63 212.5 0.1 1.6 2 0 0 2 2 2 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) DSPc PF00782.18 MSTRG.8949.1_1 - 1.8e-07 30.9 0.0 3.2e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 MSTRG.8949.1_1 - 1.2e-05 24.9 0.0 2.1e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase RhoGAP PF00620.25 MSTRG.7201.1_1 - 4.2e-39 133.7 0.2 8.2e-39 132.7 0.2 1.4 1 0 0 1 1 1 1 RhoGAP domain START PF01852.17 MSTRG.7201.1_1 - 4.5e-27 94.7 0.9 6.9e-27 94.1 0.9 1.2 1 0 0 1 1 1 1 START domain Ig_2 PF13895.4 MSTRG.27451.3_2 - 1.9e-32 111.3 0.4 2.4e-11 43.7 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.27451.3_2 - 8.7e-30 103.0 0.8 2.6e-10 40.6 0.4 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 MSTRG.27451.3_2 - 1.9e-18 66.2 0.4 4.4e-06 26.6 0.0 4.5 3 2 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 MSTRG.27451.3_2 - 4.2e-18 65.1 0.2 0.00044 20.1 0.0 4.5 3 2 0 3 3 3 3 Immunoglobulin I-set domain V-set PF07686.15 MSTRG.27451.3_2 - 2.6e-07 30.6 4.7 1.1 9.3 0.2 5.8 3 3 1 5 5 5 2 Immunoglobulin V-set domain Ig_5 PF16681.3 MSTRG.27451.3_2 - 6.9e-07 29.5 0.1 0.11 12.8 0.0 3.4 3 0 0 3 3 3 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Protocadherin PF08374.9 MSTRG.27451.3_2 - 0.032 14.1 0.0 0.054 13.3 0.0 1.3 1 0 0 1 1 1 0 Protocadherin MFS_1 PF07690.14 MSTRG.9829.2_1 - 2e-35 122.3 36.8 1.2e-28 99.9 19.9 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 MSTRG.9829.2_1 - 1.1e-32 113.4 13.4 1.6e-27 96.3 2.4 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_4 PF06779.12 MSTRG.9829.2_1 - 6e-06 25.7 21.7 0.0014 17.8 8.1 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB OATP PF03137.18 MSTRG.9829.2_1 - 0.0009 17.5 7.8 0.078 11.1 0.1 3.1 2 1 0 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.5 MSTRG.9829.2_1 - 0.009 14.8 9.9 0.12 11.1 1.8 2.9 2 1 0 2 2 2 2 MFS_1 like family zf-C2H2_3 PF13878.4 MSTRG.20042.1_1 - 2.7 7.8 7.1 0.4 10.4 0.2 2.9 3 0 0 3 3 3 0 zinc-finger of acetyl-transferase ESCO ig PF00047.23 MSTRG.410.1_2 - 2.4e-05 24.3 0.0 3.7e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 MSTRG.410.1_2 - 7.5e-05 22.7 0.0 0.00012 22.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.4 MSTRG.410.1_2 - 0.00016 21.8 0.0 0.00031 20.9 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.410.1_2 - 0.00052 20.4 0.0 0.00088 19.7 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 MSTRG.410.1_2 - 0.17 11.9 0.0 0.23 11.4 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin I-set domain CAP PF00188.24 MSTRG.7033.1_2 - 8.7e-06 26.5 0.1 1.6e-05 25.6 0.1 1.4 1 0 0 1 1 1 1 Cysteine-rich secretory protein family EGF_CA PF07645.13 MSTRG.17434.1_1 - 0 1026.4 721.6 5.8e-11 42.3 8.6 48.2 47 1 1 49 49 49 43 Calcium-binding EGF domain cEGF PF12662.5 MSTRG.17434.1_1 - 2e-198 641.3 404.4 1.1e-09 37.9 1.2 50.2 50 0 0 50 50 50 42 Complement Clr-like EGF-like EGF PF00008.25 MSTRG.17434.1_1 - 2.3e-110 360.2 687.9 0.0001 22.4 7.4 50.0 49 0 0 49 49 49 45 EGF-like domain TB PF00683.15 MSTRG.17434.1_1 - 3.4e-95 311.4 133.0 9.4e-13 47.5 6.2 11.1 9 0 0 9 9 9 9 TB domain hEGF PF12661.5 MSTRG.17434.1_1 - 5.8e-89 289.9 649.2 7e-05 23.2 3.1 51.7 50 0 0 50 50 50 41 Human growth factor-like EGF FXa_inhibition PF14670.4 MSTRG.17434.1_1 - 1.6e-88 290.6 716.6 1e-09 38.4 9.8 49.3 44 6 5 49 49 49 40 Coagulation Factor Xa inhibitory site EGF_3 PF12947.5 MSTRG.17434.1_1 - 4.7e-38 129.0 636.7 2.2e-09 37.2 12.3 50.3 47 2 2 49 49 49 39 EGF domain Plasmod_Pvs28 PF06247.9 MSTRG.17434.1_1 - 2.2e-08 34.1 511.4 0.021 15.0 1.6 45.8 42 3 3 45 45 45 27 Pvs28 EGF domain CCDC92 PF14916.4 MSTRG.17173.1_2 - 0.0037 16.9 1.4 0.0064 16.1 1.4 1.3 1 0 0 1 1 1 1 Coiled-coil domain of unknown function Mito_carr PF00153.25 MSTRG.23591.1_3 - 2.4e-69 229.2 5.4 1.3e-25 89.0 0.2 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Surp PF01805.18 MSTRG.8476.2_3 - 2.4e-17 62.5 1.5 4.2e-17 61.7 0.1 2.2 2 0 0 2 2 2 1 Surp module CTD_bind PF04818.11 MSTRG.8476.2_3 - 2.7e-17 63.2 0.6 2.7e-17 63.2 0.6 2.1 2 0 0 2 2 2 1 RNA polymerase II-binding domain. G-patch PF01585.21 MSTRG.8476.2_3 - 6.4e-11 41.9 5.2 1.2e-10 41.0 5.2 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.5 MSTRG.8476.2_3 - 0.084 12.8 0.6 0.25 11.3 0.6 1.8 1 0 0 1 1 1 0 G-patch domain DUF3181 PF11378.6 MSTRG.8476.2_3 - 0.19 11.9 0.2 0.49 10.6 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3181) Apt1 PF10351.7 MSTRG.8476.2_3 - 0.22 10.2 17.8 0.39 9.4 17.8 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.15 MSTRG.8476.2_3 - 2.8 6.5 12.0 4.3 5.8 12.0 1.2 1 0 0 1 1 1 0 Presenilin LysM PF01476.18 MSTRG.3587.1_3 - 1.6e-06 27.9 0.0 2.5e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 LysM domain tRNA-synt_1e PF01406.17 MSTRG.5973.1_1 - 2.6e-124 414.3 0.0 4.5e-124 413.6 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.9 MSTRG.5973.1_1 - 1.1e-06 27.6 0.4 0.0011 17.7 0.1 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.20 MSTRG.5973.1_1 - 0.02 13.0 0.7 0.1 10.7 0.0 2.1 2 0 0 2 2 2 0 tRNA synthetases class I (I, L, M and V) DUF2175 PF09943.7 MSTRG.5973.1_1 - 2.5 8.3 6.3 5.2 7.3 4.4 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) zf-H2C2_2 PF13465.4 MSTRG.14705.3_2 - 8e-19 67.0 32.3 6.1e-07 29.5 0.2 6.1 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.14705.3_2 - 1.3e-13 50.5 44.5 2.4e-05 24.4 0.4 6.8 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.14705.3_2 - 1.2e-08 34.9 42.4 0.0002 21.8 0.5 7.0 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_11 PF16622.3 MSTRG.14705.3_2 - 0.0086 15.7 0.3 0.0086 15.7 0.3 4.4 4 0 0 4 4 4 1 zinc-finger C2H2-type zf-H2C2_5 PF13909.4 MSTRG.14705.3_2 - 0.0094 15.6 0.1 0.0094 15.6 0.1 5.5 5 0 0 5 5 5 2 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.6 MSTRG.14705.3_2 - 0.015 15.5 19.2 0.59 10.4 0.0 5.4 4 1 1 5 5 5 0 Zinc-finger double-stranded RNA-binding CPSF100_C PF13299.4 MSTRG.14705.3_2 - 0.025 14.7 0.0 0.053 13.6 0.0 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal zf-met PF12874.5 MSTRG.14705.3_2 - 0.098 12.9 0.1 0.098 12.9 0.1 6.2 6 0 0 6 6 6 0 Zinc-finger of C2H2 type GAGA PF09237.9 MSTRG.14705.3_2 - 0.4 10.4 4.3 0.18 11.5 0.1 2.5 2 1 1 3 3 3 0 GAGA factor CX PF01705.17 MSTRG.2479.1_3 - 0.076 13.5 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 CX module Pkinase PF00069.23 MSTRG.2506.5_3 - 1.8e-05 24.1 0.0 2.1e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.2506.5_3 - 0.0033 16.6 0.0 0.0043 16.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Utp21 PF04192.10 MSTRG.16696.4_3 - 8.8e-51 172.5 0.0 1.3e-50 171.9 0.0 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.30 MSTRG.16696.4_3 - 4.2e-15 55.7 16.4 2.4e-06 28.0 0.2 9.4 10 0 0 10 10 10 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.16696.4_3 - 5.2e-09 36.2 0.0 0.044 14.0 0.0 5.5 4 2 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 MSTRG.16696.4_3 - 0.024 14.4 0.0 0.65 9.7 0.0 2.7 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.14 MSTRG.16696.4_3 - 0.035 12.5 0.0 0.07 11.5 0.0 1.4 1 0 0 1 1 1 0 Cytochrome D1 heme domain PQQ_2 PF13360.4 MSTRG.16696.4_3 - 0.046 13.2 0.2 0.33 10.4 0.1 2.3 2 0 0 2 2 2 0 PQQ-like domain zf-C2H2 PF00096.24 MSTRG.20745.1_3 - 2.6e-13 49.5 120.9 0.0038 17.5 1.3 15.7 16 0 0 16 16 16 9 Zinc finger, C2H2 type zf-C2H2_11 PF16622.3 MSTRG.20745.1_3 - 8.5e-13 47.7 4.1 4.6e-12 45.3 1.8 9.7 10 0 0 10 10 10 3 zinc-finger C2H2-type zf-C2H2_4 PF13894.4 MSTRG.20745.1_3 - 2.9e-08 33.7 128.9 0.023 15.4 1.3 16.2 17 0 0 17 17 17 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.20745.1_3 - 0.021 15.0 0.5 0.021 15.0 0.5 10.2 10 0 0 10 10 10 0 Zinc-finger double-stranded RNA-binding RINGv PF12906.5 MSTRG.17518.1_2 - 2.1e-14 53.2 10.6 9.5e-14 51.1 10.6 2.3 1 0 0 1 1 1 1 RING-variant domain CBP PF12192.6 MSTRG.4298.1_1 - 0.083 13.0 3.7 0.26 11.4 0.4 2.5 2 0 0 2 2 2 0 Fungal calcium binding protein PARP PF00644.18 MSTRG.4298.1_3 - 2.5e-32 112.1 0.4 3.1e-31 108.5 0.4 2.3 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.18 MSTRG.4298.1_3 - 1e-13 51.5 2.1 1.2e-09 38.4 0.2 2.6 2 0 0 2 2 2 2 WWE domain Torus PF16131.3 MSTRG.4298.1_3 - 0.03 14.9 0.1 0.03 14.9 0.1 1.9 2 0 0 2 2 2 0 Torus domain P53 PF00870.16 MSTRG.18184.1_3 - 6.9e-110 365.1 0.1 1.3e-109 364.2 0.1 1.5 1 0 0 1 1 1 1 P53 DNA-binding domain P53_tetramer PF07710.9 MSTRG.18184.1_3 - 4.3e-18 64.2 0.1 9.8e-18 63.1 0.1 1.6 1 0 0 1 1 1 1 P53 tetramerisation motif SAM_2 PF07647.15 MSTRG.18184.1_3 - 6.9e-07 29.1 0.0 1.6e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 MSTRG.18184.1_3 - 0.0016 18.7 0.0 0.0032 17.7 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PT PF04886.10 MSTRG.29556.2_1 - 0.014 14.8 14.4 0.029 13.8 14.4 1.4 1 0 0 1 1 1 0 PT repeat Aha1_N PF09229.9 MSTRG.1257.5_3 - 1e-36 126.0 0.1 1.8e-36 125.2 0.1 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.9 MSTRG.1257.5_3 - 1.8e-21 76.5 0.0 3e-21 75.8 0.0 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Pkinase PF00069.23 MSTRG.21887.2_1 - 6.4e-64 215.7 0.0 8.7e-64 215.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.21887.2_1 - 1.2e-36 126.2 0.0 1.8e-36 125.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 MSTRG.21887.2_1 - 3.2e-32 110.0 23.9 3e-16 58.9 5.9 2.9 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C2 PF00168.28 MSTRG.21887.2_1 - 1.4e-13 50.8 0.0 2.5e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 C2 domain Pkinase_C PF00433.22 MSTRG.21887.2_1 - 2.8e-09 37.4 0.8 6.7e-09 36.2 0.8 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 MSTRG.21887.2_1 - 0.0078 15.4 0.0 0.018 14.2 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.12 MSTRG.21887.2_1 - 0.036 13.3 0.0 0.063 12.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 MSTRG.21887.2_1 - 0.11 11.9 0.1 2.5 7.5 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 CAP_N PF01213.17 MSTRG.21887.2_2 - 0.56 9.5 4.9 2.1 7.6 4.9 2.0 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Med26 PF08711.9 MSTRG.24861.1_1 - 1.7e-11 43.9 0.2 5.8e-11 42.1 0.0 2.0 2 0 0 2 2 2 1 TFIIS helical bundle-like domain Rap_GAP PF02145.13 MSTRG.12383.2_2 - 1.4e-46 158.3 0.0 2.4e-46 157.6 0.0 1.3 1 0 0 1 1 1 1 Rap/ran-GAP DUF2933 PF11666.6 MSTRG.12383.2_2 - 4.5 7.3 9.3 0.052 13.5 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2933) TPR_2 PF07719.15 MSTRG.11146.1_1 - 0.02 14.8 0.7 0.84 9.8 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.11146.1_1 - 0.021 15.5 2.6 0.1 13.4 0.2 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.4 MSTRG.11146.1_1 - 0.11 12.8 0.8 0.34 11.3 0.0 2.1 3 0 0 3 3 3 0 Tetratricopeptide repeat CNH PF00780.20 MSTRG.25659.3_2 - 6.9e-74 248.8 0.0 1.2e-73 247.9 0.0 1.4 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.23 MSTRG.25659.3_2 - 2.4e-56 190.9 0.0 4.9e-56 189.9 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.25659.3_2 - 3.1e-30 105.2 0.0 5.7e-30 104.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DMPK_coil PF08826.8 MSTRG.25659.3_2 - 2e-26 91.8 11.1 2e-26 91.8 11.1 7.2 6 2 1 7 7 4 2 DMPK coiled coil domain like KELK PF15796.3 MSTRG.25659.3_2 - 2.7e-24 85.3 14.7 2.7e-24 85.3 14.7 7.1 5 2 2 7 7 6 1 KELK-motif containing domain of MRCK Ser/Thr protein kinase C1_1 PF00130.20 MSTRG.25659.3_2 - 2.4e-11 43.2 8.8 5.2e-11 42.1 8.8 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.4 MSTRG.25659.3_2 - 2.4e-07 30.2 0.0 5.1e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_C PF00433.22 MSTRG.25659.3_2 - 1.9e-05 25.1 2.2 4.9e-05 23.8 2.2 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain PH PF00169.27 MSTRG.25659.3_2 - 0.00014 22.2 0.0 0.00062 20.1 0.0 2.3 1 0 0 1 1 1 1 PH domain PBD PF00786.26 MSTRG.25659.3_2 - 0.00085 19.5 0.3 0.037 14.3 0.1 3.1 3 0 0 3 3 3 1 P21-Rho-binding domain Seadorna_VP7 PF07387.9 MSTRG.25659.3_2 - 0.087 11.7 0.1 0.19 10.6 0.1 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 C1_2 PF03107.14 MSTRG.25659.3_2 - 4.8 7.4 7.1 14 5.9 7.1 1.9 1 0 0 1 1 1 0 C1 domain PDZ PF00595.22 MSTRG.18703.4_1 - 1.7e-39 133.9 5.6 4.4e-12 46.1 0.2 3.4 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.18703.4_1 - 7.4e-14 51.7 1.3 0.00032 20.8 0.1 3.5 3 0 0 3 3 3 3 PDZ domain Guanylate_kin PF00625.19 MSTRG.18703.4_1 - 4.4e-12 45.9 0.0 1.8e-11 43.9 0.0 1.9 1 1 1 2 2 2 1 Guanylate kinase SH3_2 PF07653.15 MSTRG.18703.4_1 - 5.4e-09 35.5 0.1 3.3e-08 33.0 0.0 2.5 3 0 0 3 3 3 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.18703.4_1 - 0.00021 20.7 0.0 0.0011 18.4 0.0 2.2 2 0 0 2 2 2 1 SH3 domain p450 PF00067.20 MSTRG.17414.1_1 - 2e-10 39.9 0.0 2.1e-10 39.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CAT PF00302.16 MSTRG.17414.1_1 - 0.0082 15.9 0.0 0.01 15.6 0.0 1.0 1 0 0 1 1 1 1 Chloramphenicol acetyltransferase PLA2G12 PF06951.9 MSTRG.7734.1_3 - 3.7e-78 261.5 9.6 6e-78 260.8 9.6 1.3 1 0 0 1 1 1 1 Group XII secretory phospholipase A2 precursor (PLA2G12) Ank_2 PF12796.5 MSTRG.16222.3_2 - 1.1e-31 109.1 0.2 1.1e-11 45.0 0.0 2.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.16222.3_2 - 7.9e-18 64.1 3.3 1.5e-10 41.0 0.5 4.5 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.4 MSTRG.16222.3_2 - 2.3e-17 63.0 1.0 3e-07 30.7 0.0 4.3 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.16222.3_2 - 7.8e-16 57.6 0.2 0.0019 18.4 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.4 MSTRG.16222.3_2 - 2.5e-13 48.7 0.2 0.024 15.0 0.0 4.6 4 0 0 4 4 4 4 Ankyrin repeat Sulfotransfer_2 PF03567.12 MSTRG.23857.1_3 - 7.1e-27 94.8 0.1 1.2e-26 94.0 0.1 1.3 1 0 0 1 1 1 1 Sulfotransferase family Cyclin_N PF00134.21 MSTRG.18710.1_1 - 3e-42 143.3 2.3 3.2e-42 143.2 0.5 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 MSTRG.18710.1_1 - 1.3e-33 115.4 1.2 2.9e-33 114.4 1.2 1.6 1 0 0 1 1 1 1 Cyclin, C-terminal domain DUF1758 PF05585.10 MSTRG.18710.1_1 - 0.19 11.4 0.9 0.47 10.1 0.0 2.1 3 0 0 3 3 3 0 Putative peptidase (DUF1758) DHR-2 PF06920.11 MSTRG.22922.1_1 - 9.1e-208 691.0 5.0 9.1e-208 691.0 5.0 2.0 2 0 0 2 2 2 1 Dock homology region 2 DOCK-C2 PF14429.4 MSTRG.22922.1_1 - 1.4e-56 191.2 0.1 1e-55 188.4 0.0 2.4 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.6 MSTRG.22922.1_1 - 4.5e-34 116.6 0.2 1.5e-33 114.9 0.2 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) PH PF00169.27 MSTRG.22922.1_1 - 2.1e-15 57.0 0.2 6.1e-15 55.5 0.2 1.9 1 0 0 1 1 1 1 PH domain PH_9 PF15410.4 MSTRG.22922.1_1 - 0.00015 22.0 0.0 0.00066 19.9 0.0 2.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.4 MSTRG.22922.1_1 - 0.049 13.8 0.1 0.13 12.4 0.1 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain HAUS6_N PF14661.4 MSTRG.22922.1_1 - 0.064 12.7 1.6 0.31 10.5 0.7 2.3 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus PH_11 PF15413.4 MSTRG.22922.1_1 - 0.18 12.1 1.2 4.4 7.6 1.2 2.9 1 1 0 1 1 1 0 Pleckstrin homology domain ig PF00047.23 MSTRG.410.2_1 - 2.2e-05 24.4 0.0 3.3e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 MSTRG.410.2_1 - 6.8e-05 22.9 0.0 0.00011 22.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.4 MSTRG.410.2_1 - 0.00015 21.9 0.0 0.00028 21.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.410.2_1 - 0.00048 20.6 0.0 0.00078 19.9 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 MSTRG.410.2_1 - 0.15 12.0 0.0 0.21 11.6 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin I-set domain Ribosomal_S7 PF00177.19 MSTRG.7909.2_1 - 1.8e-12 47.0 0.0 2.3e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e LMBR1 PF04791.14 MSTRG.22686.1_3 - 1.2 7.8 5.3 0.43 9.3 0.8 1.9 2 0 0 2 2 2 0 LMBR1-like membrane protein Vps39_1 PF10366.7 MSTRG.8845.2_3 - 2.3e-30 105.0 1.1 2.3e-30 105.0 1.1 3.2 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 CNH PF00780.20 MSTRG.8845.2_3 - 3.9e-18 65.9 0.0 6.3e-18 65.2 0.0 1.3 1 0 0 1 1 1 1 CNH domain Clathrin PF00637.18 MSTRG.8845.2_3 - 2.5e-14 53.2 5.6 1e-05 25.3 0.0 3.9 3 1 0 3 3 3 2 Region in Clathrin and VPS Vps39_2 PF10367.7 MSTRG.8845.2_3 - 3.8e-06 27.1 0.3 1.9e-05 24.9 0.1 2.4 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 Cadherin_tail PF15974.3 MSTRG.15735.2_1 - 2.2e-32 112.0 11.2 3.9e-32 111.2 11.2 1.3 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 MSTRG.15735.2_1 - 6.1e-07 30.0 0.0 2.5e-06 28.0 0.0 2.1 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Coq4 PF05019.11 MSTRG.12003.3_1 - 9.5e-95 316.0 0.0 1.2e-94 315.7 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 SH3-WW_linker PF16618.3 MSTRG.9630.1_1 - 1.5e-77 260.4 21.1 1.5e-77 260.4 21.1 2.0 2 0 0 2 2 2 1 Linker region between SH3 and WW domains on ARHGAP12 WW PF00397.24 MSTRG.9630.1_1 - 3.8e-13 49.0 19.1 1e-07 31.6 1.4 4.0 3 1 1 4 4 4 2 WW domain SH3_9 PF14604.4 MSTRG.9630.1_1 - 2e-10 40.2 0.4 5.4e-10 38.8 0.2 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.9630.1_1 - 2.6e-05 23.6 1.5 3.8e-05 23.1 0.3 1.9 2 0 0 2 2 2 1 SH3 domain ATP-synt_C PF00137.19 MSTRG.11329.1_2 - 1.2e-10 41.4 12.4 2.3e-10 40.5 12.4 1.5 1 0 0 1 1 1 1 ATP synthase subunit C Frizzled PF01534.15 MSTRG.11686.1_2 - 2.9e-92 309.1 15.4 4e-92 308.6 15.4 1.2 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.20 MSTRG.11686.1_2 - 9.1e-16 58.4 4.4 1.9e-15 57.4 4.4 1.5 1 0 0 1 1 1 1 Fz domain Dicty_CAR PF05462.9 MSTRG.11686.1_2 - 2.2e-05 23.6 2.4 2.2e-05 23.6 2.4 1.9 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor DUF2735 PF10931.6 MSTRG.11686.1_2 - 0.11 13.1 0.4 34 5.1 0.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2735) DUF3715 PF12509.6 MSTRG.14478.3_1 - 9.5e-25 87.2 0.0 1.4e-24 86.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3715) DDE_Tnp_1_6 PF13751.4 MSTRG.14478.3_3 - 4.4 7.4 6.3 10 6.2 6.3 1.6 1 0 0 1 1 1 0 Transposase DDE domain Hox9_act PF04617.11 MSTRG.17245.1_2 - 1.3e-30 107.4 0.5 1.9e-30 106.9 0.5 1.2 1 0 0 1 1 1 1 Hox9 activation region Homeobox PF00046.27 MSTRG.17245.1_2 - 7.6e-21 73.6 4.7 1.2e-20 72.9 4.7 1.3 1 0 0 1 1 1 1 Homeobox domain HTH_23 PF13384.4 MSTRG.17245.1_2 - 0.03 14.0 0.0 0.061 13.0 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain EF-hand_1 PF00036.30 MSTRG.16680.3_2 - 4.3e-17 60.2 6.5 6.4e-07 28.3 0.4 3.3 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.4 MSTRG.16680.3_2 - 9.1e-17 61.2 3.4 1.8e-12 47.4 1.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 MSTRG.16680.3_2 - 9.4e-14 50.8 6.2 7.3e-10 38.3 0.2 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.16680.3_2 - 3.1e-13 48.4 4.0 0.00031 20.3 0.1 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.4 MSTRG.16680.3_2 - 2.9e-09 35.9 6.7 0.00052 19.3 0.1 3.1 3 0 0 3 3 3 2 EF hand EF-hand_9 PF14658.4 MSTRG.16680.3_2 - 1.1e-07 31.9 0.0 6.7e-06 26.2 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain GRASP55_65 PF04495.12 MSTRG.4269.1_3 - 9.6e-62 207.2 0.0 6.2e-51 172.2 0.0 2.3 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.4 MSTRG.4269.1_3 - 1.5e-07 31.5 0.0 0.00041 20.5 0.0 2.6 2 0 0 2 2 2 2 PDZ domain tRNA-synt_2b PF00587.23 MSTRG.3100.1_1 - 1.1e-44 152.4 0.1 4.5e-44 150.4 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.20 MSTRG.3100.1_1 - 1.5e-19 70.0 1.0 1.5e-19 70.0 1.0 2.6 3 0 0 3 3 3 1 Seryl-tRNA synthetase N-terminal domain NOD PF06816.11 MSTRG.3100.1_1 - 0.013 14.9 0.2 0.095 12.2 0.0 2.2 2 0 0 2 2 2 0 NOTCH protein PDZ PF00595.22 MSTRG.24993.2_3 - 6.6e-09 35.9 0.1 1.1e-08 35.2 0.1 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PK PF00224.19 MSTRG.14279.1_1 - 2e-153 510.2 0.7 2.5e-153 509.9 0.7 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.14 MSTRG.14279.1_1 - 1.5e-31 108.9 0.0 3.9e-31 107.6 0.0 1.8 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.12 MSTRG.14279.1_1 - 2.2e-06 26.8 0.1 6.8e-06 25.2 0.0 1.7 1 1 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family IMPDH PF00478.23 MSTRG.14279.1_1 - 0.004 16.1 0.2 0.016 14.1 0.0 1.9 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain Phosphodiest PF01663.20 MSTRG.6485.1_2 - 2.9e-74 250.7 0.2 3.5e-74 250.4 0.2 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.21 MSTRG.6485.1_2 - 3.1e-06 26.7 0.1 0.0086 15.4 0.0 2.2 1 1 1 2 2 2 2 Sulfatase DUF1501 PF07394.10 MSTRG.6485.1_2 - 0.073 12.0 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Med24_N PF11277.6 MSTRG.155.5_2 - 1.9e-55 188.3 1.0 2.1e-55 188.1 1.0 1.0 1 0 0 1 1 1 1 Mediator complex subunit 24 N-terminal KA1 PF02149.17 MSTRG.155.5_2 - 0.085 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Kinase associated domain 1 V-set PF07686.15 MSTRG.4495.1_1 - 2.2e-11 43.8 0.0 3.3e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain SLC3A2_N PF16028.3 MSTRG.4495.1_1 - 0.016 14.6 3.4 0.04 13.3 3.4 1.7 1 0 0 1 1 1 0 Solute carrier family 3 member 2 N-terminus Sas10_Utp3 PF04000.13 MSTRG.18315.6_1 - 8.7e-14 51.8 0.0 1.3e-13 51.2 0.0 1.3 1 0 0 1 1 1 1 Sas10/Utp3/C1D family DUF932 PF06067.9 MSTRG.18315.6_1 - 0.028 14.0 0.3 0.032 13.9 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF932) fn3 PF00041.19 MSTRG.29772.1_2 - 3.3e-35 120.1 2.8 9.3e-17 61.0 0.0 5.0 4 1 0 4 4 4 3 Fibronectin type III domain fn3_2 PF16893.3 MSTRG.29772.1_2 - 2.4e-12 46.7 0.0 0.00051 20.0 0.0 3.3 3 0 0 3 3 3 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 MSTRG.29772.1_2 - 8.3e-12 45.4 0.6 0.0017 18.7 0.1 4.0 3 1 0 3 3 3 3 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 MSTRG.29772.1_2 - 2.4e-06 27.7 0.0 0.044 14.0 0.0 3.2 3 0 0 3 3 3 2 Interferon-alpha/beta receptor, fibronectin type III DUF4959 PF16323.3 MSTRG.29772.1_2 - 0.0052 17.0 0.0 0.31 11.2 0.0 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4959) Glyco_hydro_36C PF16874.3 MSTRG.29772.1_2 - 0.058 13.8 0.1 1.4 9.3 0.0 2.7 3 0 0 3 3 3 0 Glycosyl hydrolase family 36 C-terminal domain TPR_12 PF13424.4 MSTRG.9676.1_3 - 9.3e-05 22.5 0.1 0.0089 16.2 0.1 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat Cob_adeno_trans PF01923.16 MSTRG.3082.2_3 - 4.4e-57 192.7 0.0 5.4e-57 192.4 0.0 1.1 1 0 0 1 1 1 1 Cobalamin adenosyltransferase DUF4389 PF14333.4 MSTRG.3082.2_3 - 0.072 12.9 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4389) Nucleoplasmin PF03066.13 MSTRG.20853.2_2 - 4.9e-41 139.2 0.7 6.4e-41 138.9 0.0 1.6 2 0 0 2 2 1 1 Nucleoplasmin/nucleophosmin domain CENP-B_dimeris PF09026.8 MSTRG.20853.2_2 - 0.018 15.3 16.8 0.018 15.3 16.8 2.2 3 0 0 3 3 3 0 Centromere protein B dimerisation domain RXT2_N PF08595.9 MSTRG.20853.2_2 - 0.065 13.1 13.9 0.088 12.7 10.2 2.1 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF1510 PF07423.9 MSTRG.20853.2_2 - 0.089 12.1 10.9 0.16 11.3 10.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Pox_Ag35 PF03286.12 MSTRG.20853.2_2 - 0.11 12.1 15.8 0.048 13.3 12.7 1.9 2 0 0 2 2 2 0 Pox virus Ag35 surface protein NOA36 PF06524.10 MSTRG.20853.2_2 - 0.15 11.2 15.8 0.016 14.4 11.6 1.4 2 0 0 2 2 2 0 NOA36 protein Vfa1 PF08432.8 MSTRG.20853.2_2 - 0.57 10.4 14.4 0.047 13.9 9.8 1.5 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Prothymosin PF03247.12 MSTRG.20853.2_2 - 0.58 10.5 0.1 0.58 10.5 0.1 3.0 2 1 1 3 3 3 0 Prothymosin/parathymosin family DNA_pol_phi PF04931.11 MSTRG.20853.2_2 - 1 7.3 18.6 1.4 6.8 18.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF913 PF06025.10 MSTRG.20853.2_2 - 1.6 7.5 4.9 2 7.1 4.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CDC45 PF02724.12 MSTRG.20853.2_2 - 2.1 6.4 12.8 2.9 6.0 12.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.10 MSTRG.20853.2_2 - 3.1 5.8 17.5 0.098 10.7 11.9 1.2 2 0 0 2 2 2 0 Nop14-like family RR_TM4-6 PF06459.10 MSTRG.20853.2_2 - 3.8 7.1 10.9 2.2 7.9 8.4 1.7 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 zf-LITAF-like PF10601.7 MSTRG.27481.1_3 - 1.8e-09 37.6 11.2 1.8e-09 37.6 11.2 3.1 3 0 0 3 3 3 1 LITAF-like zinc ribbon domain EF-hand_1 PF00036.30 MSTRG.12878.3_1 - 1.1e-11 43.3 4.5 0.004 16.5 0.2 4.5 4 1 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 MSTRG.12878.3_1 - 2.9e-09 36.0 4.9 0.0014 18.3 0.1 4.6 4 1 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.4 MSTRG.12878.3_1 - 3e-09 37.1 1.9 5.5e-06 26.6 0.1 3.6 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.12878.3_1 - 1.2e-06 27.7 4.5 0.025 14.0 0.0 3.6 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.4 MSTRG.12878.3_1 - 5.1e-05 22.8 0.1 0.00038 20.0 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain pair Clr5 PF14420.4 MSTRG.10041.1_2 - 0.086 13.0 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Clr5 domain PDZ PF00595.22 MSTRG.10144.2_1 - 1.5e-24 86.0 0.7 2.2e-11 43.8 0.1 2.4 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) DUF812 PF05667.9 MSTRG.10144.2_1 - 0.0042 15.9 4.5 0.0064 15.3 4.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) DUF1664 PF07889.10 MSTRG.10144.2_1 - 0.93 9.4 2.5 2.4 8.0 2.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) IncA PF04156.12 MSTRG.10144.2_1 - 2.7 7.6 12.4 5.7 6.5 12.4 1.5 1 0 0 1 1 1 0 IncA protein Fez1 PF06818.13 MSTRG.10144.2_1 - 4.3 7.6 14.3 8.5 6.6 14.3 1.4 1 0 0 1 1 1 0 Fez1 DUF572 PF04502.11 MSTRG.10144.2_1 - 8.1 5.8 7.7 13 5.1 7.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Lung_7-TM_R PF06814.11 MSTRG.8843.1_3 - 2.4e-83 279.6 15.3 3.3e-83 279.1 15.3 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor SPT6_acidic PF14632.4 MSTRG.8843.1_3 - 0.15 12.5 1.6 0.32 11.5 1.6 1.4 1 0 0 1 1 1 0 Acidic N-terminal SPT6 Dimer_Tnp_hAT PF05699.12 MSTRG.15531.1_3 - 5.6e-13 48.4 0.1 7.3e-13 48.0 0.1 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region RNA_pol_A_bac PF01000.24 MSTRG.4556.1_2 - 1.6e-37 128.2 0.4 3.2e-37 127.2 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.22 MSTRG.4556.1_2 - 2.5e-17 61.9 0.0 3.8e-17 61.3 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain ADK PF00406.20 MSTRG.25002.1_3 - 2.9e-05 24.1 0.0 4e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.4 MSTRG.25002.1_3 - 0.0077 16.5 0.0 0.012 15.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain Tim44 PF04280.13 MSTRG.25002.1_3 - 0.05 13.6 0.0 0.071 13.1 0.0 1.2 1 0 0 1 1 1 0 Tim44-like domain SH3_9 PF14604.4 MSTRG.24196.1_2 - 1.9e-11 43.5 0.1 3.8e-11 42.5 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.24196.1_2 - 2e-10 40.0 0.2 3.2e-10 39.3 0.2 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.24196.1_2 - 4.4e-08 32.6 0.0 6.9e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 MSTRG.24196.1_2 - 2.9e-05 24.1 0.2 5.3e-05 23.3 0.2 1.3 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_4 PF06347.11 MSTRG.24196.1_2 - 0.018 14.7 0.0 0.04 13.6 0.0 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain GerA PF03323.11 MSTRG.10124.1_2 - 0.061 11.6 0.0 0.082 11.2 0.0 1.1 1 0 0 1 1 1 0 Bacillus/Clostridium GerA spore germination protein Snapin_Pallidin PF14712.4 MSTRG.6763.2_3 - 1.3e-25 89.5 3.6 1.8e-25 89.0 3.6 1.2 1 0 0 1 1 1 1 Snapin/Pallidin Laminin_II PF06009.10 MSTRG.6763.2_3 - 0.22 11.4 2.9 0.33 10.8 2.9 1.2 1 0 0 1 1 1 0 Laminin Domain II HrpJ PF07201.9 MSTRG.15476.1_2 - 0.091 12.9 0.9 0.14 12.4 0.9 1.2 1 0 0 1 1 1 0 HrpJ-like domain 7tm_1 PF00001.19 MSTRG.15476.1_3 - 2.2e-06 27.0 0.0 2.7e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 MSTRG.15476.1_3 - 0.035 13.3 0.0 0.054 12.7 0.0 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw CBP_BcsO PF17037.3 MSTRG.8206.1_3 - 0.0058 16.7 1.5 0.0058 16.7 1.5 3.9 4 1 0 4 4 4 1 Cellulose biosynthesis protein BcsO DUF3678 PF12435.6 MSTRG.22221.1_2 - 0.32 10.1 3.8 0.59 9.3 3.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3678) HSBP1 PF06825.10 MSTRG.22221.1_3 - 3.6e-28 97.1 7.5 5.7e-28 96.5 7.5 1.3 1 0 0 1 1 1 1 Heat shock factor binding protein 1 CLZ PF16526.3 MSTRG.22221.1_3 - 0.028 14.6 0.2 0.045 14.0 0.2 1.3 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Ank_2 PF12796.5 MSTRG.26857.2_1 - 1.8e-42 143.7 8.8 5e-18 65.3 0.4 3.5 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.26857.2_1 - 1e-36 124.7 18.0 2.8e-11 43.6 0.1 5.3 2 1 4 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.26857.2_1 - 2.3e-33 113.1 14.4 3.1e-05 24.1 0.0 8.5 9 0 0 9 9 9 6 Ankyrin repeat Ank_5 PF13857.4 MSTRG.26857.2_1 - 2.5e-29 100.7 12.4 2.7e-08 33.8 1.6 5.9 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.26857.2_1 - 7.1e-25 84.2 13.4 5.8e-05 23.0 0.0 7.4 7 0 0 7 7 7 6 Ankyrin repeat Ribosomal_60s PF00428.17 MSTRG.26857.2_1 - 4.3 7.8 19.6 14 6.2 19.3 2.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein WBP-1 PF11669.6 MSTRG.19057.1_1 - 2.6e-44 150.0 12.0 5.7e-44 148.9 12.0 1.6 1 0 0 1 1 1 1 WW domain-binding protein 1 TMEM52 PF14979.4 MSTRG.19057.1_1 - 0.97 9.2 8.5 2.6 7.8 8.5 1.7 1 0 0 1 1 1 0 Transmembrane 52 YIF1 PF03878.13 MSTRG.17021.2_3 - 7.2e-85 284.2 5.2 9.9e-85 283.7 5.2 1.2 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.15 MSTRG.17021.2_3 - 2.8e-09 36.8 9.4 5.5e-09 35.8 9.4 1.4 1 0 0 1 1 1 1 Yip1 domain SLY PF12485.6 MSTRG.8905.1_3 - 5.1e-32 111.6 9.2 1.7e-31 110.0 9.2 2.0 1 0 0 1 1 1 1 Lymphocyte signaling adaptor protein SAM_1 PF00536.28 MSTRG.8905.1_3 - 8.4e-21 74.1 0.1 8.7e-10 38.8 0.0 2.5 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 MSTRG.8905.1_3 - 1.3e-20 73.1 0.9 7.4e-11 41.9 0.0 2.8 3 0 0 3 3 3 2 SAM domain (Sterile alpha motif) SH3_2 PF07653.15 MSTRG.8905.1_3 - 0.00035 20.1 0.0 0.00077 19.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain NCD1 PF04904.11 MSTRG.8905.1_3 - 0.013 15.4 1.1 7.8 6.4 0.0 2.9 3 0 0 3 3 3 0 NAB conserved region 1 (NCD1) CoiA PF06054.9 MSTRG.8905.1_3 - 0.056 12.4 0.1 0.09 11.8 0.1 1.2 1 0 0 1 1 1 0 Competence protein CoiA-like family MCM PF00493.21 MSTRG.21777.4_2 - 1.1e-133 445.3 0.0 1.5e-133 444.9 0.0 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_OB PF17207.1 MSTRG.21777.4_2 - 7.1e-39 132.4 1.6 1.3e-38 131.6 1.6 1.4 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.19 MSTRG.21777.4_2 - 8e-07 28.5 0.0 0.00024 20.4 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.12 MSTRG.21777.4_2 - 0.0012 18.7 0.2 0.0089 15.9 0.1 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.24 MSTRG.21777.4_2 - 0.024 14.2 0.0 0.22 11.1 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_3 PF07726.9 MSTRG.21777.4_2 - 0.032 14.0 0.0 0.11 12.2 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Cyclin_N PF00134.21 MSTRG.15011.2_3 - 4.2e-18 65.2 0.0 1.9e-16 59.9 0.0 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 MSTRG.15011.2_3 - 2.2e-05 24.4 0.0 5.2e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Cyclin, C-terminal domain Cyclin_C_2 PF16899.3 MSTRG.15011.2_3 - 0.087 13.1 0.0 0.47 10.7 0.0 2.1 2 0 0 2 2 2 0 Cyclin C-terminal domain ADH_zinc_N_2 PF13602.4 MSTRG.10877.1_3 - 7.6e-22 78.7 0.0 1.3e-21 77.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.24 MSTRG.10877.1_3 - 9.3e-18 64.3 0.0 1.5e-17 63.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 MSTRG.10877.1_3 - 2.2e-10 40.2 0.0 4.8e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PGAP1 PF07819.11 MSTRG.10877.1_3 - 0.14 11.7 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein RNA_pol_Rpc4 PF05132.12 MSTRG.10877.1_3 - 0.15 12.4 16.7 2.6 8.4 11.7 2.4 2 0 0 2 2 2 0 RNA polymerase III RPC4 Zip PF02535.20 MSTRG.10877.1_3 - 0.53 9.3 4.6 1 8.3 4.6 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter RP-C_C PF11800.6 MSTRG.10877.1_3 - 5.5 6.9 7.2 14 5.5 3.5 2.1 2 0 0 2 2 2 0 Replication protein C C-terminal region CDC45 PF02724.12 MSTRG.10877.1_3 - 6.3 4.8 16.2 9.4 4.3 16.2 1.1 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.11 MSTRG.10877.1_3 - 8.3 4.9 10.6 14 4.2 10.6 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Enolase_C PF00113.20 MSTRG.23145.1_3 - 9.4e-159 527.2 0.0 1.5e-158 526.5 0.0 1.3 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.14 MSTRG.23145.1_3 - 2.7e-60 202.1 0.1 5.2e-60 201.2 0.1 1.5 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.4 MSTRG.23145.1_3 - 1.5e-08 34.5 0.0 2.3e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.9 MSTRG.23145.1_3 - 0.00073 18.6 0.9 0.0015 17.6 0.9 1.5 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus PID PF00640.21 MSTRG.1176.1_3 - 4.3e-19 68.8 1.2 5.3e-19 68.5 1.2 1.1 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PID_2 PF14719.4 MSTRG.1176.1_3 - 2.2e-17 63.4 0.5 2.4e-17 63.3 0.5 1.0 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 MSTRG.1176.1_3 - 1.5e-08 34.7 0.3 1.9e-08 34.4 0.3 1.1 1 0 0 1 1 1 1 Phosphotyrosine-binding domain FERM_C PF09380.8 MSTRG.1176.1_3 - 0.057 13.7 0.1 0.1 12.8 0.1 1.5 1 0 0 1 1 1 0 FERM C-terminal PH-like domain Tropomyosin PF00261.18 MSTRG.23581.2_2 - 1.4e-91 306.0 63.2 1.4e-91 306.0 63.2 2.1 2 0 0 2 2 2 1 Tropomyosin Tropomyosin_1 PF12718.5 MSTRG.23581.2_2 - 4.7e-38 130.4 74.7 1.1e-34 119.5 40.3 2.5 1 1 1 2 2 2 2 Tropomyosin like CLZ PF16526.3 MSTRG.23581.2_2 - 4.8e-05 23.5 48.6 8e-05 22.8 11.2 4.6 2 2 2 4 4 4 3 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Laminin_II PF06009.10 MSTRG.23581.2_2 - 5.7e-05 23.0 36.1 0.00019 21.3 10.5 3.5 1 1 2 3 3 3 2 Laminin Domain II Laminin_I PF06008.12 MSTRG.23581.2_2 - 2.8 7.5 57.5 0.12 12.0 15.7 3.2 1 1 2 3 3 3 0 Laminin Domain I Vhr1 PF04001.11 MSTRG.23581.2_2 - 3.8 7.7 6.7 7.7 6.8 0.7 2.7 2 0 0 2 2 2 0 Transcription factor Vhr1 ERM PF00769.17 MSTRG.23581.2_2 - 9.3 5.9 82.0 1.7 8.3 31.6 3.2 1 1 2 3 3 3 0 Ezrin/radixin/moesin family TFIID-31kDa PF02291.13 MSTRG.903.1_3 - 9.7e-49 164.4 0.5 1.4e-48 163.9 0.0 1.5 2 0 0 2 2 2 1 Transcription initiation factor IID, 31kD subunit CENP-S PF15630.4 MSTRG.903.1_3 - 3.6e-06 27.1 0.1 3.6e-06 27.1 0.1 1.9 2 0 0 2 2 2 1 CENP-S protein Histone PF00125.22 MSTRG.903.1_3 - 0.0003 21.1 0.0 0.00084 19.6 0.0 1.8 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.11 MSTRG.903.1_3 - 0.00036 20.4 0.1 0.00071 19.4 0.1 1.4 1 0 0 1 1 1 1 Bromodomain associated CENP-T_C PF15511.4 MSTRG.903.1_3 - 0.042 13.8 2.6 0.078 13.0 0.1 2.2 2 0 0 2 2 2 0 Centromere kinetochore component CENP-T histone fold TFIID_20kDa PF03847.11 MSTRG.903.1_3 - 0.16 12.4 0.1 0.35 11.3 0.1 1.5 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A UPF0061 PF02696.12 MSTRG.22160.1_3 - 2.5e-124 415.5 0.0 4.8e-124 414.5 0.0 1.4 1 1 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family DUF3636 PF12331.6 MSTRG.22160.1_3 - 0.028 14.1 0.5 0.047 13.4 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3636) DUF2110 PF09883.7 MSTRG.1513.1_2 - 0.18 11.3 0.0 0.26 10.8 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2110) Vta1 PF04652.14 MSTRG.16385.2_1 - 1e-51 174.6 2.8 2.5e-51 173.4 1.2 1.9 2 0 0 2 2 2 1 Vta1 like Tropomodulin PF03250.12 MSTRG.6536.1_3 - 3e-13 49.9 6.9 3e-13 49.9 6.9 2.0 2 0 0 2 2 2 1 Tropomodulin LRR_6 PF13516.4 MSTRG.6536.1_3 - 0.32 11.0 1.2 0.88 9.7 0.0 2.4 2 0 0 2 2 2 0 Leucine Rich repeat ATP-synt PF00231.17 MSTRG.24284.1_3 - 1.8e-44 152.4 0.8 2.1e-44 152.2 0.8 1.0 1 0 0 1 1 1 1 ATP synthase WD40 PF00400.30 MSTRG.26595.1_1 - 8.2e-11 42.2 16.5 0.0004 21.0 2.0 6.3 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.26595.1_1 - 8.2e-09 35.5 0.1 0.045 13.9 0.0 4.2 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.6 MSTRG.26595.1_1 - 0.14 10.3 0.1 0.23 9.6 0.1 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz BUD22 PF09073.8 MSTRG.26595.1_1 - 1.5 7.9 6.1 2.2 7.4 6.1 1.1 1 0 0 1 1 1 0 BUD22 Ribophorin_II PF05817.12 MSTRG.13037.6_2 - 9e-42 143.3 0.5 4.6e-36 124.4 0.2 2.0 2 0 0 2 2 2 2 Oligosaccharyltransferase subunit Ribophorin II Forkhead PF00250.16 MSTRG.15629.1_3 - 0.17 12.1 1.2 0.2 11.9 1.2 1.1 1 0 0 1 1 1 0 Forkhead domain bZIP_1 PF00170.19 MSTRG.8024.1_1 - 1.6e-07 31.2 17.7 2.8e-07 30.4 17.7 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.15 MSTRG.8024.1_1 - 3.2e-05 24.2 14.8 6.2e-05 23.3 14.8 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_2 PF07716.13 MSTRG.8024.1_1 - 5.6e-05 23.0 16.5 0.0001 22.1 16.5 1.5 1 0 0 1 1 1 1 Basic region leucine zipper Macoilin PF09726.7 MSTRG.8024.1_1 - 0.31 9.4 15.8 0.024 13.1 10.8 1.5 1 1 0 1 1 1 0 Transmembrane protein DUF4094 PF13334.4 MSTRG.8024.1_1 - 0.42 10.9 3.4 1.1 9.5 3.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) Mnd1 PF03962.13 MSTRG.8024.1_1 - 0.62 9.8 7.6 0.99 9.1 7.6 1.2 1 0 0 1 1 1 0 Mnd1 family APG6 PF04111.10 MSTRG.8024.1_1 - 0.83 8.9 9.2 1.2 8.3 9.2 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 HALZ PF02183.16 MSTRG.8024.1_1 - 1.6 8.9 9.1 0.69 10.0 5.6 2.1 2 0 0 2 2 2 0 Homeobox associated leucine zipper CTP_transf_like PF01467.24 MSTRG.9437.1_3 - 3.3e-31 108.3 0.1 5.8e-31 107.5 0.1 1.4 1 0 0 1 1 1 1 Cytidylyltransferase-like Mei5 PF10376.7 MSTRG.9437.1_3 - 0.0046 16.7 0.7 0.0072 16.1 0.7 1.2 1 0 0 1 1 1 1 Double-strand recombination repair protein SMC_N PF02463.17 MSTRG.26697.1_2 - 6.3e-21 74.7 0.0 1.2e-20 73.7 0.0 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.4 MSTRG.26697.1_2 - 3.1e-12 47.3 63.5 9e-10 39.3 32.7 5.1 3 1 0 3 3 3 2 AAA domain AAA_21 PF13304.4 MSTRG.26697.1_2 - 3e-06 27.1 0.4 0.026 14.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.4 MSTRG.26697.1_2 - 1.2e-05 25.0 13.5 1.2e-05 25.0 13.5 3.2 2 1 1 3 3 3 1 AAA ATPase domain AAA_29 PF13555.4 MSTRG.26697.1_2 - 0.0016 18.0 0.0 0.0032 17.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain NCD3G PF07562.12 MSTRG.26697.1_2 - 0.19 11.6 41.9 0.32 10.9 6.9 6.1 4 1 1 5 5 5 0 Nine Cysteines Domain of family 3 GPCR FtsK_SpoIIIE PF01580.16 MSTRG.26697.1_2 - 0.38 9.9 3.6 0.34 10.1 0.1 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family DEAD PF00270.27 MSTRG.23200.2_2 - 4.1e-45 153.6 0.0 7.8e-45 152.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase GUCT PF08152.10 MSTRG.23200.2_2 - 2.7e-31 107.5 0.0 6.5e-31 106.3 0.0 1.7 1 0 0 1 1 1 1 GUCT (NUC152) domain Helicase_C PF00271.29 MSTRG.23200.2_2 - 5.5e-30 103.9 0.0 1.9e-29 102.1 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.23200.2_2 - 3e-09 37.0 0.0 1.1e-08 35.1 0.0 1.9 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.4 MSTRG.23200.2_2 - 0.00013 21.3 0.0 0.00013 21.3 0.0 2.0 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit AAA_30 PF13604.4 MSTRG.23200.2_2 - 0.0011 18.6 0.0 0.014 15.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain ERCC3_RAD25_C PF16203.3 MSTRG.23200.2_2 - 0.0021 17.2 1.2 0.0024 17.0 0.0 1.7 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase RR_TM4-6 PF06459.10 MSTRG.23200.2_2 - 5.4 6.6 11.6 10 5.7 11.6 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DHC_N1 PF08385.10 MSTRG.3479.1_2 - 3.6e-11 42.3 0.0 3.8e-11 42.2 0.0 1.0 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 MAPEG PF01124.16 MSTRG.3645.2_1 - 0.39 10.5 8.3 0.66 9.7 7.6 1.7 1 1 1 2 2 2 0 MAPEG family WH1 PF00568.21 MSTRG.10628.1_2 - 1e-35 121.9 0.2 1.3e-35 121.5 0.2 1.1 1 0 0 1 1 1 1 WH1 domain RRM_1 PF00076.20 MSTRG.6624.3_3 - 2.2e-25 88.1 0.8 1.3e-12 47.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 MSTRG.6624.3_3 - 2.1e-09 36.9 0.1 0.00082 18.8 0.1 2.3 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 MSTRG.6624.3_3 - 4.5e-05 23.1 0.0 0.2 11.4 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif RNA_bind PF08675.9 MSTRG.6624.3_3 - 0.0081 16.0 0.0 5.8 6.9 0.0 2.4 2 0 0 2 2 2 2 RNA binding domain Limkain-b1 PF11608.6 MSTRG.6624.3_3 - 0.013 15.4 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 Limkain b1 DbpA PF03880.13 MSTRG.6624.3_3 - 0.079 12.8 0.0 6.5 6.7 0.0 2.2 2 0 0 2 2 2 0 DbpA RNA binding domain ADAM_spacer1 PF05986.12 MSTRG.11185.1_1 - 4.3e-29 100.7 0.0 6.9e-29 100.1 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.17 MSTRG.11185.1_1 - 1.9e-09 37.4 40.6 3e-08 33.6 5.5 5.1 5 0 0 5 5 5 3 Thrombospondin type 1 domain TSP_1 PF00090.17 MSTRG.11185.1_3 - 0.0018 18.3 12.3 0.0018 18.3 12.3 2.9 3 0 0 3 3 3 1 Thrombospondin type 1 domain PLAC PF08686.9 MSTRG.11185.1_3 - 0.007 16.9 7.2 0.007 16.9 7.2 2.2 2 0 0 2 2 2 1 PLAC (protease and lacunin) domain zf-H2C2_2 PF13465.4 MSTRG.14409.1_1 - 7e-31 105.2 44.3 2e-06 27.9 2.2 7.2 7 0 0 7 7 6 5 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.14409.1_1 - 2.7e-19 68.3 43.2 6.4e-06 26.2 2.1 6.2 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.14409.1_1 - 3.4e-11 42.8 52.1 0.001 19.6 0.7 6.8 6 0 0 6 6 5 5 C2H2-type zinc finger BolA PF01722.16 MSTRG.14409.1_1 - 0.007 16.5 8.9 3.6 7.8 3.2 4.2 1 1 2 3 3 3 1 BolA-like protein zf-LYAR PF08790.9 MSTRG.14409.1_1 - 0.0092 15.7 15.0 0.54 10.1 0.2 4.8 4 0 0 4 4 4 2 LYAR-type C2HC zinc finger zf-met PF12874.5 MSTRG.14409.1_1 - 0.11 12.8 37.2 0.59 10.5 2.7 6.1 6 0 0 6 6 6 0 Zinc-finger of C2H2 type GAGA PF09237.9 MSTRG.14409.1_1 - 0.14 11.8 2.1 0.45 10.2 0.5 2.6 1 1 1 2 2 2 0 GAGA factor DUF3268 PF11672.6 MSTRG.14409.1_1 - 1.7 8.9 11.0 1.8 8.8 0.8 3.1 1 1 2 4 4 4 0 zinc-finger-containing domain LIM PF00412.20 MSTRG.14409.1_1 - 1.9 8.7 23.3 1.9 8.6 3.2 5.7 1 1 4 5 5 5 0 LIM domain zf-HYPF PF07503.10 MSTRG.14409.1_1 - 2.5 7.8 15.5 37 4.1 0.1 5.7 5 0 0 5 5 5 0 HypF finger zf-CHCC PF10276.7 MSTRG.14409.1_1 - 4.9 7.2 9.3 72 3.4 0.1 4.7 4 0 0 4 4 4 0 Zinc-finger domain HA2 PF04408.21 MSTRG.17358.1_2 - 2.9e-20 72.4 0.0 2.9e-20 72.4 0.0 4.1 3 2 0 3 3 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.14 MSTRG.17358.1_2 - 8.5e-19 67.6 0.0 2.5e-18 66.1 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.29 MSTRG.17358.1_2 - 2.5e-12 47.0 0.0 5.6e-12 45.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.27 MSTRG.17358.1_2 - 9e-07 28.7 0.1 2e-06 27.6 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.4 MSTRG.17358.1_2 - 1.8e-05 24.9 0.1 4e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.4 MSTRG.17358.1_2 - 0.00075 19.7 0.1 0.0017 18.5 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.4 MSTRG.17358.1_2 - 0.0041 16.7 0.0 0.0096 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.18 MSTRG.17358.1_2 - 0.006 15.5 0.0 0.011 14.6 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_33 PF13671.4 MSTRG.17358.1_2 - 0.0089 16.0 0.0 0.038 14.0 0.0 2.2 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.20 MSTRG.17358.1_2 - 0.031 13.2 0.0 0.057 12.3 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_16 PF13191.4 MSTRG.17358.1_2 - 0.088 13.0 0.0 0.25 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain Flavi_DEAD PF07652.12 MSTRG.17358.1_2 - 0.093 12.6 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain PhoH PF02562.14 MSTRG.17358.1_2 - 0.096 12.0 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein TraD PF06412.9 MSTRG.17358.1_2 - 0.71 9.6 5.1 0.28 10.9 0.2 2.8 3 0 0 3 3 3 0 Conjugal transfer protein TraD F420_oxidored PF03807.15 MSTRG.9714.1_1 - 8.9e-18 64.5 0.1 1.5e-17 63.8 0.1 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Ferric_reduct PF01794.17 MSTRG.9714.1_1 - 1e-12 48.2 0.3 1e-12 48.2 0.3 2.8 2 1 1 3 3 3 1 Ferric reductase like transmembrane component 2-Hacid_dh_C PF02826.17 MSTRG.9714.1_1 - 9e-07 28.3 0.0 1.8e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.13 MSTRG.9714.1_1 - 9.5e-07 29.0 0.0 1.6e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.18 MSTRG.9714.1_1 - 1.6e-05 24.9 0.0 2.7e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase IlvN PF07991.10 MSTRG.9714.1_1 - 0.00016 21.1 0.0 0.00026 20.5 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Atrophin-1 PF03154.13 MSTRG.28023.1_1 - 8e-122 408.3 31.8 9.8e-122 408.0 31.8 1.1 1 0 0 1 1 1 1 Atrophin-1 family Atrophin-1 PF03154.13 MSTRG.28023.1_3 - 1.1e-68 232.4 9.3 1.1e-68 232.4 9.3 1.5 2 0 0 2 2 2 1 Atrophin-1 family DUF1682 PF07946.12 MSTRG.28023.1_3 - 0.19 10.7 8.3 0.28 10.2 8.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Carb_anhydrase PF00194.19 MSTRG.16360.1_3 - 1.8e-62 211.1 0.4 2.1e-62 210.8 0.4 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase GFA PF04828.12 MSTRG.22853.2_3 - 1.8e-09 37.6 1.4 4.3e-09 36.5 1.4 1.6 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme F-box-like PF12937.5 MSTRG.7294.1_3 - 5.1e-14 51.8 1.2 1.2e-13 50.6 1.2 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 MSTRG.7294.1_3 - 5.1e-11 42.0 1.8 1.4e-10 40.6 1.8 1.8 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.5 MSTRG.7294.1_3 - 0.0045 17.2 0.9 4.4 7.7 0.0 3.8 2 2 2 4 4 4 2 Leucine Rich repeats (2 copies) DUF547 PF04784.12 MSTRG.22917.1_3 - 1.4e-34 118.4 0.0 3.1e-34 117.2 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF547 Glutaredoxin PF00462.22 MSTRG.22917.1_3 - 6.6e-16 58.2 0.1 1.2e-15 57.4 0.1 1.4 1 0 0 1 1 1 1 Glutaredoxin DEP PF00610.19 MSTRG.22917.1_3 - 0.0051 16.7 0.0 0.014 15.3 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF836 PF05768.12 MSTRG.22917.1_3 - 0.02 15.2 0.0 0.043 14.1 0.0 1.6 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) HAT_KAT11 PF08214.9 MSTRG.18898.1_2 - 7.3e-67 226.0 0.3 1.5e-66 225.0 0.3 1.5 1 0 0 1 1 1 1 Histone acetylation protein Creb_binding PF09030.8 MSTRG.18898.1_2 - 2e-39 134.5 24.7 2e-39 134.5 24.7 11.5 5 3 3 10 10 10 1 Creb binding KIX PF02172.14 MSTRG.18898.1_2 - 2.9e-39 133.1 0.7 6.1e-39 132.0 0.7 1.6 1 0 0 1 1 1 1 KIX domain zf-TAZ PF02135.14 MSTRG.18898.1_2 - 8.1e-27 93.4 57.1 8.5e-19 67.7 20.6 3.9 3 0 0 3 3 3 2 TAZ zinc finger DUF902 PF06001.11 MSTRG.18898.1_2 - 4e-19 68.7 9.1 4e-19 68.7 9.1 2.6 2 0 0 2 2 2 1 Domain of Unknown Function (DUF902) Bromodomain PF00439.23 MSTRG.18898.1_2 - 2.7e-17 62.5 0.1 5.8e-17 61.4 0.1 1.5 1 0 0 1 1 1 1 Bromodomain ZZ PF00569.15 MSTRG.18898.1_2 - 5.5e-15 54.8 12.6 5.5e-15 54.8 12.6 3.2 4 0 0 4 4 4 1 Zinc finger, ZZ type KIX_2 PF16987.3 MSTRG.18898.1_2 - 0.00028 20.7 0.2 0.00028 20.7 0.2 2.8 2 0 0 2 2 2 1 KIX domain Npa1 PF11707.6 MSTRG.18898.1_2 - 0.00093 18.5 0.0 0.0016 17.8 0.0 1.3 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal Phospholamban PF04272.12 MSTRG.18898.1_2 - 0.24 10.8 1.6 0.61 9.5 0.3 2.4 2 0 0 2 2 2 0 Phospholamban SUIM_assoc PF16619.3 MSTRG.11181.1_2 - 0.52 10.3 9.0 1.2 9.2 9.0 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.6 MSTRG.11181.1_2 - 5.6 6.4 7.7 7.9 5.9 7.7 1.1 1 0 0 1 1 1 0 Spt20 family zf-CCHC_2 PF13696.4 MSTRG.7395.1_2 - 8.6 6.1 12.4 0.38 10.5 4.6 2.7 2 1 0 2 2 2 0 Zinc knuckle CRAL_TRIO_2 PF13716.4 MSTRG.12484.2_1 - 4.8e-12 46.0 0.0 9.1e-12 45.1 0.0 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.18 MSTRG.12484.2_1 - 0.0015 18.1 0.0 0.0049 16.5 0.0 1.9 2 0 0 2 2 2 1 CRAL/TRIO domain Sld5 PF05916.9 MSTRG.12317.1_3 - 1.2e-06 28.8 0.0 2e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 GINS complex protein Myosin_tail_1 PF01576.17 MSTRG.7995.5_3 - 0 1654.0 302.3 0 1653.7 302.3 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.19 MSTRG.7995.5_3 - 0 1013.3 1.5 0 1013.3 1.5 3.1 3 0 0 3 3 3 1 Myosin head (motor domain) Myosin_N PF02736.17 MSTRG.7995.5_3 - 3.3e-11 42.7 1.1 7.5e-11 41.5 1.1 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain IQ PF00612.25 MSTRG.7995.5_3 - 7.9e-05 22.0 0.4 0.00025 20.4 0.4 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif ADIP PF11559.6 MSTRG.7995.5_3 - 0.00025 21.0 19.4 0.00025 21.0 19.4 14.4 1 1 12 14 14 14 4 Afadin- and alpha -actinin-Binding TPR_MLP1_2 PF07926.10 MSTRG.7995.5_3 - 0.0004 20.3 11.7 0.0004 20.3 11.7 11.9 2 2 9 11 11 11 3 TPR/MLP1/MLP2-like protein AAA_22 PF13401.4 MSTRG.7995.5_3 - 0.048 13.8 0.0 0.048 13.8 0.0 5.7 5 2 0 5 5 5 0 AAA domain Reo_sigmaC PF04582.10 MSTRG.7995.5_3 - 0.087 12.1 66.3 0.62 9.3 3.2 9.0 2 1 5 10 10 10 0 Reovirus sigma C capsid protein DUF903 PF06004.10 MSTRG.7995.5_3 - 0.14 12.0 0.4 0.3 10.9 0.4 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF903) TMF_DNA_bd PF12329.6 MSTRG.26182.1_1 - 2.7e-19 68.8 20.0 2.7e-19 68.8 20.0 7.5 5 2 1 8 8 8 3 TATA element modulatory factor 1 DNA binding PilW PF16074.3 MSTRG.26182.1_1 - 0.18 11.7 1.0 0.6 10.0 0.4 2.1 1 1 1 2 2 2 0 Type IV Pilus-assembly protein W Hexapep PF00132.22 MSTRG.27963.1_2 - 1.6e-09 37.0 14.9 3.5e-05 23.2 1.6 4.3 3 1 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Cytochrome_C7 PF14522.4 MSTRG.7912.1_3 - 0.035 14.0 1.0 0.09 12.7 1.0 1.7 1 0 0 1 1 1 0 Cytochrome c7 and related cytochrome c DUF1589 PF07628.9 MSTRG.12536.1_1 - 0.1 12.6 0.0 0.24 11.4 0.0 1.5 1 1 0 2 2 2 0 Protein of unknown function (DUF1589) START PF01852.17 MSTRG.28121.2_1 - 9.1e-35 119.8 1.7 2e-34 118.7 1.7 1.5 1 0 0 1 1 1 1 START domain PH PF00169.27 MSTRG.28121.2_1 - 2.3e-12 47.2 0.3 6.5e-12 45.8 0.3 1.8 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 MSTRG.28121.2_1 - 2.4e-06 27.6 0.5 6.8e-06 26.1 0.1 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.4 MSTRG.28121.2_1 - 0.00011 22.4 1.9 0.0024 18.1 1.9 2.7 1 1 0 1 1 1 1 Pleckstrin homology domain Acyl_CoA_thio PF02551.13 MSTRG.28121.2_1 - 0.038 13.7 0.0 0.18 11.5 0.0 2.0 2 0 0 2 2 2 0 Acyl-CoA thioesterase CREPT PF16566.3 MSTRG.28121.2_1 - 0.12 12.4 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Scramblase PF03803.13 MSTRG.8192.1_1 - 3.3e-87 291.3 0.0 5.1e-87 290.7 0.0 1.3 1 0 0 1 1 1 1 Scramblase Ribosomal_L22e PF01776.15 MSTRG.20519.1_2 - 1.7e-52 176.3 0.8 2.4e-52 175.8 0.8 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family Toxin_27 PF08099.9 MSTRG.11996.1_3 - 0.15 12.1 0.1 0.15 12.1 0.1 3.4 4 0 0 4 4 4 0 Scorpion calcine family ITAM_Cys-rich PF10538.7 MSTRG.11996.1_3 - 0.3 10.8 4.0 0.5 10.0 4.0 1.3 1 0 0 1 1 1 0 Immunoreceptor tyrosine-based activation motif Lipocalin_7 PF14651.4 MSTRG.7483.1_1 - 1e-35 122.3 0.2 1.2e-35 122.0 0.2 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Alpha_L_fucos PF01120.15 MSTRG.8925.1_3 - 7.8e-125 416.6 0.6 1e-124 416.3 0.6 1.1 1 0 0 1 1 1 1 Alpha-L-fucosidase Fucosidase_C PF16757.3 MSTRG.8925.1_3 - 4.6e-27 94.3 0.0 8.4e-27 93.4 0.0 1.5 1 0 0 1 1 1 1 Alpha-L-fucosidase C-terminal domain Homeobox PF00046.27 MSTRG.23053.1_1 - 9.8e-18 63.6 6.9 2.2e-17 62.4 6.9 1.6 1 0 0 1 1 1 1 Homeobox domain DUF3915 PF13054.4 MSTRG.23053.1_1 - 0.026 14.4 0.3 0.052 13.4 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Homez PF11569.6 MSTRG.23053.1_1 - 0.32 10.3 2.0 0.37 10.2 0.2 2.0 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.9 MSTRG.23053.1_1 - 0.74 9.6 6.7 0.1 12.4 1.7 2.1 2 0 0 2 2 2 0 Homeobox KN domain RhlB PF12300.6 MSTRG.23053.1_1 - 4.8 7.2 9.5 0.21 11.7 3.1 1.9 2 0 0 2 2 2 0 ATP-dependent RNA helicase RhlB Tim54 PF11711.6 MSTRG.23053.1_3 - 0.015 13.9 0.7 0.023 13.3 0.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 BCIP PF13862.4 MSTRG.23053.1_3 - 0.13 11.9 2.3 0.18 11.4 2.3 1.2 1 0 0 1 1 1 0 p21-C-terminal region-binding protein DUF2098 PF09871.7 MSTRG.23053.1_3 - 1.2 9.3 3.5 2.4 8.4 3.5 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) U1snRNP70_N PF12220.6 MSTRG.23053.1_3 - 1.4 9.5 9.5 3 8.4 9.5 1.5 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF3915 PF13054.4 MSTRG.23053.1_3 - 2.2 8.1 7.0 4.7 7.1 7.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) NARP1 PF12569.6 MSTRG.23053.1_3 - 5.8 5.5 8.3 8 5.1 8.3 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 WT1 PF02165.13 MSTRG.11625.1_1 - 7.4e-126 419.2 26.4 2.1e-99 332.4 20.9 2.2 1 1 1 2 2 2 2 Wilm's tumour protein zf-H2C2_2 PF13465.4 MSTRG.11625.1_1 - 4.1e-15 55.3 29.1 1.1e-06 28.6 2.2 5.0 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.11625.1_1 - 9.2e-15 54.1 36.3 4.3e-05 23.6 1.5 5.4 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_8 PF15909.3 MSTRG.11625.1_1 - 0.00086 19.4 7.6 0.21 11.8 0.6 2.9 1 1 1 2 2 2 2 C2H2-type zinc ribbon zf-met PF12874.5 MSTRG.11625.1_1 - 0.0011 19.1 3.0 0.0011 19.1 3.0 6.1 7 0 0 7 7 7 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.4 MSTRG.11625.1_1 - 0.0012 19.4 39.2 0.015 15.9 1.0 5.7 5 0 0 5 5 5 3 C2H2-type zinc finger FOXP-CC PF16159.3 MSTRG.11625.1_1 - 0.0028 18.1 0.4 0.0028 18.1 0.4 2.8 3 1 0 3 3 3 1 FOXP coiled-coil domain zf-C2H2_jaz PF12171.6 MSTRG.11625.1_1 - 0.75 10.1 14.6 0.25 11.6 1.1 4.6 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding PI3_PI4_kinase PF00454.25 MSTRG.25129.2_2 - 9.9e-49 166.3 1.3 2.5e-47 161.7 1.3 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase C2 PF00168.28 MSTRG.25129.2_2 - 4.9e-10 39.5 0.2 1.2e-09 38.3 0.2 1.7 1 0 0 1 1 1 1 C2 domain PX PF00787.22 MSTRG.25129.2_2 - 0.00017 21.4 0.1 0.00039 20.2 0.1 1.6 1 0 0 1 1 1 1 PX domain DUF4135 PF13575.4 MSTRG.25129.2_2 - 0.0021 17.3 0.0 0.0032 16.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) Tubulin PF00091.23 MSTRG.11808.1_3 - 8.9e-69 231.5 0.0 1.2e-68 231.1 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 MSTRG.11808.1_3 - 5.2e-51 172.0 0.0 8.3e-51 171.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 MSTRG.11808.1_3 - 0.002 17.7 0.0 0.0039 16.8 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain 14-3-3 PF00244.18 MSTRG.17675.1_2 - 2.5e-106 354.0 10.7 3.2e-106 353.6 10.7 1.1 1 0 0 1 1 1 1 14-3-3 protein Virulence_fact PF13769.4 MSTRG.17675.1_2 - 0.058 13.4 1.9 0.18 11.8 0.2 2.4 3 0 0 3 3 3 0 Virulence factor FliM PF02154.13 MSTRG.17675.1_2 - 0.086 12.6 0.1 0.15 11.8 0.1 1.3 1 0 0 1 1 1 0 Flagellar motor switch protein FliM zf-B_box PF00643.22 MSTRG.8202.3_2 - 7.1e-08 32.3 7.1 7.1e-08 32.3 7.1 3.4 3 0 0 3 3 3 1 B-box zinc finger zf-RING_UBOX PF13445.4 MSTRG.8202.3_2 - 8.5e-06 25.6 3.7 3.2e-05 23.7 3.7 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 MSTRG.8202.3_2 - 0.00048 20.1 2.1 0.00048 20.1 2.1 2.7 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 MSTRG.8202.3_2 - 0.00051 19.7 1.2 0.00051 19.7 1.2 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 MSTRG.8202.3_2 - 0.0032 17.2 0.4 0.0032 17.2 0.4 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 MSTRG.8202.3_2 - 0.037 13.8 0.4 0.037 13.8 0.4 2.9 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Calsequestrin PF01216.15 MSTRG.8202.3_2 - 0.22 10.4 0.2 0.32 9.8 0.2 1.1 1 0 0 1 1 1 0 Calsequestrin DUF1917 PF08939.8 MSTRG.8202.3_2 - 0.31 10.7 2.3 0.61 9.8 1.2 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF1917) BUD22 PF09073.8 MSTRG.8202.3_3 - 0.2 10.8 23.2 0.29 10.3 23.2 1.1 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.10 MSTRG.8202.3_3 - 0.74 9.1 27.3 1.1 8.5 27.3 1.1 1 0 0 1 1 1 0 SDA1 FA_desaturase PF00487.22 MSTRG.10184.2_2 - 2.2e-11 44.0 8.1 3.6e-11 43.2 8.1 1.3 1 0 0 1 1 1 1 Fatty acid desaturase wnt PF00110.17 MSTRG.24192.3_1 - 1.2e-103 346.8 19.8 1.6e-103 346.3 19.8 1.2 1 0 0 1 1 1 1 wnt family PX PF00787.22 MSTRG.19332.4_1 - 2.1e-17 63.0 0.1 4.6e-17 61.9 0.1 1.5 1 0 0 1 1 1 1 PX domain Kinesin_assoc PF16183.3 MSTRG.19332.4_1 - 9.7e-09 35.5 8.9 0.00029 20.9 0.2 2.8 2 1 1 3 3 3 2 Kinesin-associated FHA PF00498.24 MSTRG.19332.4_1 - 4.7e-05 23.5 0.0 8.9e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.3 MSTRG.19332.4_1 - 0.00045 20.4 0.0 0.00088 19.4 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Stealth_CR2 PF11380.6 MSTRG.1817.1_1 - 1.1e-31 109.1 0.3 1.2e-31 108.9 0.3 1.0 1 0 0 1 1 1 1 Stealth protein CR2, conserved region 2 PfkB PF00294.22 MSTRG.4925.2_1 - 8.3e-69 232.0 0.1 1e-68 231.7 0.1 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase End_tail_spike PF12219.6 MSTRG.4925.2_1 - 0.17 11.8 0.0 0.33 10.9 0.0 1.4 1 0 0 1 1 1 0 Catalytic domain of bacteriophage endosialidase C1-set PF07654.13 MSTRG.8860.3_1 - 1.4e-15 57.4 0.0 2.4e-15 56.6 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain C2-set_2 PF08205.10 MSTRG.8860.3_1 - 0.00024 21.0 0.0 0.00042 20.2 0.0 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain RGS12_usC PF16612.3 MSTRG.8860.3_1 - 0.18 12.1 0.1 0.18 12.1 0.1 1.6 2 0 0 2 2 2 0 C-terminal unstructured region of RGS12 ANAPC4_WD40 PF12894.5 MSTRG.9994.2_2 - 0.0029 17.8 1.0 0.28 11.4 0.0 3.6 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain EF1_GNE PF00736.17 MSTRG.15599.1_1 - 4.4e-36 122.8 1.3 1.8e-35 120.9 0.6 2.1 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.7 MSTRG.15599.1_1 - 3.4e-12 46.4 6.2 3.4e-12 46.4 6.2 2.6 2 0 0 2 2 1 1 Eukaryotic elongation factor 1 beta central acidic region JIP_LZII PF16471.3 MSTRG.15599.1_1 - 0.0068 16.4 0.9 0.022 14.8 0.9 1.9 1 0 0 1 1 1 1 JNK-interacting protein leucine zipper II CCD48 PF15799.3 MSTRG.15599.1_1 - 0.013 13.8 3.7 0.018 13.4 3.7 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 48 DivIC PF04977.13 MSTRG.15599.1_1 - 0.03 14.0 0.2 0.03 14.0 0.2 2.0 2 0 0 2 2 2 0 Septum formation initiator Ribosomal_60s PF00428.17 MSTRG.15599.1_1 - 0.092 13.2 4.7 0.1 13.0 1.5 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein bZIP_1 PF00170.19 MSTRG.15599.1_1 - 0.29 11.1 2.1 0.76 9.8 0.4 2.5 2 1 1 3 3 3 0 bZIP transcription factor CLZ PF16526.3 MSTRG.15599.1_1 - 0.34 11.1 3.2 0.78 10.0 1.5 2.5 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels bZIP_2 PF07716.13 MSTRG.15599.1_1 - 0.66 10.0 3.6 23 5.0 3.6 2.8 1 1 0 1 1 1 0 Basic region leucine zipper DUF1843 PF08898.8 MSTRG.15599.1_1 - 1 9.7 4.2 0.41 11.1 1.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) Stm1_N PF09598.8 MSTRG.15599.1_1 - 2.2 9.1 5.5 9.9 7.0 0.3 2.5 2 0 0 2 2 2 0 Stm1 Filamin PF00630.17 MSTRG.20474.4_1 - 0 1190.8 41.9 3.8e-18 66.1 0.0 23.2 23 0 0 23 23 23 23 Filamin/ABP280 repeat CH PF00307.29 MSTRG.20474.4_1 - 6.5e-39 132.4 1.1 8.4e-21 74.1 0.9 2.6 2 0 0 2 2 2 2 Calponin homology (CH) domain Y_Y_Y PF07495.11 MSTRG.20474.4_1 - 1.8e-18 66.1 19.5 0.17 11.8 0.1 13.9 14 0 0 14 14 14 6 Y_Y_Y domain Big_3_5 PF16640.3 MSTRG.20474.4_1 - 6.4e-12 45.4 41.0 0.0088 16.1 0.1 14.5 17 0 0 17 17 17 4 Bacterial Ig-like domain (group 3) DUF5060 PF16586.3 MSTRG.20474.4_1 - 1.3e-11 44.6 2.4 6.4 7.1 0.0 12.5 15 0 0 15 15 14 1 Domain of unknown function (DUF5060) YtkA PF13115.4 MSTRG.20474.4_1 - 2e-10 41.0 12.0 0.9 10.1 0.0 12.7 15 0 0 15 15 15 1 YtkA-like Invasin_D3 PF09134.8 MSTRG.20474.4_1 - 1.3e-06 27.9 4.2 13 5.4 0.0 8.7 10 0 0 10 10 10 1 Invasin, domain 3 PapC_N PF13954.4 MSTRG.20474.4_1 - 1.8e-05 24.6 0.0 1.7 8.5 0.0 6.5 7 1 0 7 7 7 1 PapC N-terminal domain EMP24_GP25L PF01105.22 MSTRG.20474.4_1 - 0.00041 20.2 0.2 1.8 8.3 0.1 5.6 7 0 0 7 7 7 1 emp24/gp25L/p24 family/GOLD Wzt_C PF14524.4 MSTRG.20474.4_1 - 0.012 15.4 0.2 6.1 6.7 0.0 5.0 5 0 0 5 5 5 0 Wzt C-terminal domain CH_2 PF06294.9 MSTRG.20474.4_1 - 0.036 14.1 0.4 1.1 9.3 0.1 2.3 2 0 0 2 2 2 0 CH-like domain in sperm protein NADHdh_A3 PF14987.4 MSTRG.6867.1_1 - 6.9e-38 128.7 0.1 9.3e-38 128.3 0.1 1.2 1 0 0 1 1 1 1 NADH dehydrogenase 1 alpha subcomplex subunit 3 HLH PF00010.24 MSTRG.16969.1_3 - 7.7e-12 44.9 3.0 1.6e-11 43.9 3.0 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF773 PF05600.10 MSTRG.16969.1_3 - 0.15 10.7 5.9 0.24 10.0 5.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF773) Fmp27_WPPW PF10359.7 MSTRG.16969.1_3 - 0.57 8.8 6.6 0.89 8.2 6.6 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Glyco_transf_29 PF00777.16 MSTRG.25006.1_2 - 7.1e-32 110.7 0.0 1e-31 110.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) adh_short PF00106.23 MSTRG.7529.2_3 - 4.6e-49 166.4 0.0 5.8e-49 166.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 MSTRG.7529.2_3 - 2.4e-30 105.7 0.0 3e-30 105.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 MSTRG.7529.2_3 - 1.4e-10 41.2 0.0 2.2e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.13 MSTRG.7529.2_3 - 0.19 10.7 0.0 0.28 10.2 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DOR PF14839.4 MSTRG.6557.3_3 - 1.9e-43 149.1 18.7 2.7e-42 145.3 18.7 2.1 1 1 0 1 1 1 1 DOR family PBD PF00786.26 MSTRG.9399.4_2 - 4.4e-24 84.5 0.0 2.1e-23 82.4 0.0 2.3 1 0 0 1 1 1 1 P21-Rho-binding domain Pkinase PF00069.23 MSTRG.9399.4_2 - 9.5e-12 44.7 0.2 1.6e-11 43.9 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.9399.4_2 - 2.3e-05 23.7 0.1 3.7e-05 23.0 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ribosomal_60s PF00428.17 MSTRG.9399.4_2 - 0.0031 17.9 7.9 0.0031 17.9 7.9 1.9 2 0 0 2 2 1 1 60s Acidic ribosomal protein DUF2052 PF09747.7 MSTRG.9399.4_2 - 0.0082 16.2 5.1 0.015 15.3 5.1 1.4 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) Spt5_N PF11942.6 MSTRG.9399.4_2 - 0.012 16.4 12.4 0.032 15.1 12.4 1.7 1 1 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Nop53 PF07767.9 MSTRG.9399.4_2 - 0.041 13.2 6.6 0.023 14.0 3.7 2.0 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) CDC45 PF02724.12 MSTRG.9399.4_2 - 0.081 11.1 3.6 0.11 10.6 3.6 1.2 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.11 MSTRG.9399.4_2 - 0.39 8.6 5.9 0.57 8.1 5.9 1.2 1 0 0 1 1 1 0 DNA polymerase phi Astro_capsid_p PF12226.6 MSTRG.9399.4_2 - 0.98 8.4 8.3 0.96 8.4 6.9 1.6 2 0 0 2 2 2 0 Turkey astrovirus capsid protein CENP-B_dimeris PF09026.8 MSTRG.9399.4_2 - 1.1 9.5 12.8 2.2 8.6 12.8 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.10 MSTRG.9399.4_2 - 2.3 7.4 6.1 3.6 6.7 6.1 1.2 1 0 0 1 1 1 0 NOA36 protein FAM176 PF14851.4 MSTRG.9399.4_2 - 4.4 6.9 6.6 0.76 9.3 2.7 1.7 2 0 0 2 2 2 0 FAM176 family RXT2_N PF08595.9 MSTRG.9399.4_2 - 4.9 7.0 9.5 1.8 8.5 6.0 1.9 1 1 1 2 2 2 0 RXT2-like, N-terminal NAP PF00956.16 MSTRG.22123.4_3 - 1.4e-101 339.0 1.5 2.3e-101 338.4 1.5 1.3 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) RNA_pol_3_Rpc31 PF11705.6 MSTRG.22123.4_3 - 0.0084 16.2 5.0 0.0084 16.2 5.0 1.6 2 0 0 2 2 2 1 DNA-directed RNA polymerase III subunit Rpc31 DNA_pol_phi PF04931.11 MSTRG.22123.4_3 - 1.8 6.5 7.4 2.8 5.8 7.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi Cwf_Cwc_15 PF04889.10 MSTRG.22123.4_3 - 3 7.4 8.7 0.18 11.4 2.9 1.7 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DUF2457 PF10446.7 MSTRG.22123.4_3 - 3 6.7 11.3 5.3 6.0 11.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Ephrin_rec_like PF07699.11 MSTRG.21797.1_2 - 1e-08 34.7 69.1 8.6e-05 22.1 3.0 8.8 5 3 4 9 9 9 7 Putative ephrin-receptor like NCD3G PF07562.12 MSTRG.21797.1_2 - 0.01 15.7 52.1 0.022 14.6 6.3 6.7 6 0 0 6 6 6 0 Nine Cysteines Domain of family 3 GPCR TNFR_c6 PF00020.16 MSTRG.21797.1_2 - 5.1 7.5 47.5 0.55 10.6 0.4 8.4 4 3 3 7 7 7 0 TNFR/NGFR cysteine-rich region ubiquitin PF00240.21 MSTRG.27347.1_3 - 2.6e-06 26.9 0.2 6.2e-06 25.7 0.2 1.6 1 1 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.4 MSTRG.27347.1_3 - 0.00058 20.1 0.2 0.0034 17.7 0.2 2.0 1 1 0 1 1 1 1 Ubiquitin-like domain AbLIM_anchor PF16182.3 MSTRG.19598.1_3 - 1.6e-68 232.1 6.4 2e-49 169.3 1.1 2.4 1 1 1 2 2 2 2 Putative adherens-junction anchoring region of AbLIM VHP PF02209.17 MSTRG.19598.1_3 - 1.4e-13 50.5 1.2 3.7e-13 49.2 1.2 1.8 1 0 0 1 1 1 1 Villin headpiece domain HMG_box PF00505.17 MSTRG.27012.1_1 - 2.9e-17 62.7 0.2 5.8e-17 61.7 0.2 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 MSTRG.27012.1_1 - 3.2e-11 43.5 0.3 6.1e-11 42.6 0.3 1.4 1 0 0 1 1 1 1 HMG-box domain YABBY PF04690.11 MSTRG.27012.1_1 - 0.49 10.8 4.8 1.6 9.2 4.8 1.9 1 1 0 1 1 1 0 YABBY protein NAM-associated PF14303.4 MSTRG.27012.1_1 - 0.58 10.7 8.1 1 9.8 8.1 1.4 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain CNDH2_C PF16858.3 MSTRG.27012.1_1 - 9.7 5.9 11.6 0.45 10.3 5.4 1.7 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term ETRAMP PF09716.8 MSTRG.15446.1_1 - 0.15 12.0 1.1 0.31 11.0 1.1 1.5 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Peptidase_C14 PF00656.20 MSTRG.15446.1_2 - 8.7e-55 186.2 0.0 1.2e-54 185.8 0.0 1.2 1 0 0 1 1 1 1 Caspase domain SNF2_N PF00176.21 MSTRG.23980.2_2 - 1.7e-58 197.9 0.1 3.1e-58 197.0 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.29 MSTRG.23980.2_2 - 1.9e-17 63.5 0.0 1.3e-16 60.8 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.23980.2_2 - 1.6e-10 41.1 0.0 4.9e-10 39.5 0.0 1.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.6 MSTRG.23980.2_2 - 1.9e-09 37.0 0.0 3.5e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.27 MSTRG.23980.2_2 - 0.0032 17.1 0.0 0.0052 16.4 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.4 MSTRG.23980.2_2 - 0.019 15.1 0.2 0.067 13.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain ERCC3_RAD25_C PF16203.3 MSTRG.23980.2_2 - 0.034 13.2 0.0 0.13 11.3 0.0 2.0 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase TniB PF05621.9 MSTRG.23980.2_2 - 0.13 11.3 0.1 0.45 9.5 0.0 1.8 2 0 0 2 2 2 0 Bacterial TniB protein DUF3323 PF11796.6 MSTRG.23980.2_2 - 0.32 10.7 4.6 0.59 9.8 4.6 1.4 1 0 0 1 1 1 0 Protein of unknown function N-terminus (DUF3323) Pox_Ag35 PF03286.12 MSTRG.23980.2_2 - 2.8 7.6 9.7 0.023 14.3 1.4 1.7 2 0 0 2 2 2 0 Pox virus Ag35 surface protein PAP2 PF01569.19 MSTRG.19649.1_1 - 7e-25 87.3 3.1 1.3e-24 86.4 3.1 1.4 1 0 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.4 MSTRG.19649.1_1 - 0.0075 16.6 3.7 0.021 15.2 3.7 1.8 1 0 0 1 1 1 1 PAP2 superfamily C-terminal DUF2976 PF11190.6 MSTRG.19649.1_1 - 0.16 11.6 0.4 0.48 10.1 0.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2976) Pescadillo_N PF06732.9 MSTRG.5632.1_3 - 4.8e-125 416.5 5.6 4.8e-125 416.5 5.6 2.4 2 1 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.3 MSTRG.5632.1_3 - 1.2e-10 41.5 0.1 2.6e-10 40.4 0.1 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.24 MSTRG.5632.1_3 - 0.0039 17.4 0.0 0.015 15.5 0.0 2.1 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain ExbD PF02472.14 MSTRG.5632.1_3 - 0.3 11.1 3.7 0.73 9.9 0.7 2.3 2 0 0 2 2 2 0 Biopolymer transport protein ExbD/TolR Sporozoite_P67 PF05642.9 MSTRG.5632.1_3 - 2 6.3 10.1 3.3 5.5 10.1 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Basic PF01586.14 MSTRG.13856.1_1 - 1.2e-29 103.2 0.3 7.7e-29 100.6 0.0 2.3 2 0 0 2 2 2 1 Myogenic Basic domain HLH PF00010.24 MSTRG.13856.1_1 - 2.5e-12 46.4 4.7 5.2e-12 45.4 4.7 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain JUPITER PF17054.3 MSTRG.27838.1_3 - 2.3e-05 23.9 0.1 3.5e-05 23.3 0.1 1.3 1 0 0 1 1 1 1 Microtubule-Associated protein Jupiter RRM_1 PF00076.20 MSTRG.17085.1_1 - 1.8e-11 43.5 0.0 9.3e-11 41.3 0.0 2.0 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP PF00641.16 MSTRG.17085.1_1 - 3.6e-09 35.6 4.6 6.1e-09 34.9 4.6 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others DUF4459 PF14673.4 MSTRG.17085.1_2 - 0.04 13.7 0.0 0.076 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4459) Connexin PF00029.17 MSTRG.23440.1_1 - 2.6e-93 311.8 1.8 3.7e-93 311.3 1.8 1.2 1 0 0 1 1 1 1 Connexin Connexin43 PF03508.11 MSTRG.23440.1_1 - 2.4e-12 46.0 2.9 4.7e-12 45.1 2.9 1.5 1 0 0 1 1 1 1 Gap junction alpha-1 protein (Cx43) Connexin40_C PF16791.3 MSTRG.23440.1_1 - 0.0088 17.2 1.0 0.038 15.1 1.0 2.0 1 1 0 1 1 1 1 Connexin 40 C-terminal domain AA_permease_2 PF13520.4 MSTRG.23440.1_1 - 0.03 13.0 0.0 0.048 12.4 0.0 1.2 1 0 0 1 1 1 0 Amino acid permease HTH_Tnp_Tc3_2 PF01498.16 MSTRG.18177.1_1 - 1.9e-20 72.8 8.0 2.8e-20 72.2 8.0 1.3 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.4 MSTRG.18177.1_1 - 0.00025 20.5 0.5 0.00055 19.4 0.5 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.4 MSTRG.18177.1_1 - 0.016 15.7 5.3 0.018 15.5 0.5 2.2 2 0 0 2 2 2 0 Homeodomain-like domain HTH_21 PF13276.4 MSTRG.18177.1_1 - 0.04 13.9 4.4 0.092 12.8 4.4 1.6 1 0 0 1 1 1 0 HTH-like domain HTH_38 PF13936.4 MSTRG.18177.1_3 - 0.00088 18.9 0.1 0.0015 18.1 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.4 MSTRG.18177.1_3 - 0.0089 15.7 0.0 0.016 14.9 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_31 PF13560.4 MSTRG.18177.1_3 - 0.046 13.9 0.0 0.07 13.4 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain SelR PF01641.16 MSTRG.7126.1_1 - 2.1e-48 163.2 0.1 2.9e-48 162.8 0.1 1.2 1 0 0 1 1 1 1 SelR domain Yippee-Mis18 PF03226.12 MSTRG.7126.1_1 - 0.029 14.5 0.2 0.068 13.2 0.2 1.6 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zinc_ribbon_10 PF10058.7 MSTRG.7126.1_1 - 0.094 12.3 0.1 0.094 12.3 0.1 1.9 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Yip1 PF04893.15 MSTRG.9557.1_2 - 6e-09 35.7 16.3 9.2e-09 35.1 16.3 1.3 1 0 0 1 1 1 1 Yip1 domain EF-hand_1 PF00036.30 MSTRG.13780.1_2 - 3.8e-16 57.2 7.5 5.3e-07 28.6 1.6 3.9 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.4 MSTRG.13780.1_2 - 8.2e-14 51.7 5.1 3.7e-06 27.2 0.2 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.13780.1_2 - 2.6e-11 42.4 8.7 3.3e-07 29.6 0.9 3.5 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.4 MSTRG.13780.1_2 - 3.1e-09 36.3 7.7 3.5e-05 23.3 0.2 3.6 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.13780.1_2 - 3.9e-06 26.0 2.0 6.8e-05 22.1 1.5 2.5 2 0 0 2 2 2 1 EF hand EF-hand_11 PF08976.9 MSTRG.13780.1_2 - 0.00067 20.4 0.0 0.0014 19.3 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain EF-hand_9 PF14658.4 MSTRG.13780.1_2 - 0.022 14.9 0.0 3.4 7.9 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain GPHH PF16905.3 MSTRG.13780.1_2 - 0.06 13.0 0.0 4 7.2 0.0 2.4 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated RBD PF02196.13 MSTRG.2029.1_3 - 0.1 12.6 0.7 0.37 10.8 0.1 2.2 3 0 0 3 3 3 0 Raf-like Ras-binding domain RSRP PF17069.3 MSTRG.12364.2_2 - 0.0069 15.9 0.5 0.011 15.3 0.5 1.2 1 0 0 1 1 1 1 Arginine/Serine-Rich protein 1 RSRP PF17069.3 MSTRG.12364.2_3 - 1.9e-12 47.2 75.2 4.6e-12 46.0 75.2 1.5 1 1 0 1 1 1 1 Arginine/Serine-Rich protein 1 Trypsin PF00089.24 MSTRG.21546.4_1 - 5.1e-25 88.4 0.1 5.9e-25 88.2 0.1 1.0 1 0 0 1 1 1 1 Trypsin DUF316 PF03761.13 MSTRG.21546.4_1 - 0.14 11.5 0.0 0.14 11.5 0.0 1.1 1 0 0 1 1 1 0 Chymotrypsin family Peptidase-S1 WD40 PF00400.30 MSTRG.12672.2_2 - 1.3e-27 95.4 9.9 1.4e-06 28.7 0.0 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.12672.2_2 - 3.8e-14 52.6 3.7 1.8e-05 24.8 0.2 4.2 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 MSTRG.12672.2_2 - 0.00025 20.9 0.0 1.2 8.9 0.0 3.1 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.6 MSTRG.12672.2_2 - 0.04 12.4 0.2 0.067 11.7 0.2 1.3 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Ge1_WD40 PF16529.3 MSTRG.12672.2_2 - 0.077 11.8 0.0 0.18 10.6 0.0 1.6 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Aldolase_II PF00596.19 MSTRG.11435.1_2 - 1e-38 133.0 0.1 1.6e-38 132.4 0.1 1.3 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Tetraspannin PF00335.18 MSTRG.4449.1_3 - 7e-51 172.9 17.4 1e-50 172.3 17.4 1.3 1 0 0 1 1 1 1 Tetraspanin family T_cell_tran_alt PF15128.4 MSTRG.4449.1_3 - 0.012 15.3 0.2 0.034 13.8 0.2 1.7 1 0 0 1 1 1 0 T-cell leukemia translocation-altered Thioredoxin PF00085.18 MSTRG.10746.1_1 - 1.1e-92 304.7 0.1 4.1e-31 106.9 0.0 3.3 3 0 0 3 3 3 3 Thioredoxin Thioredoxin_6 PF13848.4 MSTRG.10746.1_1 - 7.5e-27 94.4 2.9 1.5e-19 70.6 0.5 4.3 4 0 0 4 4 4 2 Thioredoxin-like domain Thioredoxin_2 PF13098.4 MSTRG.10746.1_1 - 1.5e-15 57.4 0.9 0.00026 21.3 0.1 4.1 3 1 0 3 3 3 3 Thioredoxin-like domain Thioredoxin_7 PF13899.4 MSTRG.10746.1_1 - 8.6e-15 54.6 0.0 0.00012 22.0 0.0 3.5 3 0 0 3 3 3 3 Thioredoxin-like OST3_OST6 PF04756.11 MSTRG.10746.1_1 - 1.2e-14 54.2 0.0 3.8e-05 23.1 0.0 3.5 4 0 0 4 4 4 3 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.4 MSTRG.10746.1_1 - 5.3e-13 49.0 0.2 0.041 14.1 0.0 6.5 5 3 3 8 8 8 3 Thioredoxin-like Calsequestrin PF01216.15 MSTRG.10746.1_1 - 5.4e-10 38.7 1.9 2.9e-08 33.0 0.0 2.9 2 1 1 3 3 3 1 Calsequestrin AhpC-TSA PF00578.19 MSTRG.10746.1_1 - 1.1e-08 34.9 0.1 0.34 10.7 0.0 3.5 3 0 0 3 3 3 3 AhpC/TSA family Thioredoxin_4 PF13462.4 MSTRG.10746.1_1 - 1.5e-05 25.1 2.7 1 9.3 0.0 3.9 4 0 0 4 4 4 3 Thioredoxin Redoxin PF08534.8 MSTRG.10746.1_1 - 2.1e-05 24.1 1.4 1.9 8.0 0.0 4.6 5 0 0 5 5 5 1 Redoxin TraF PF13728.4 MSTRG.10746.1_1 - 0.00015 21.5 0.0 0.51 10.0 0.0 3.3 3 0 0 3 3 3 2 F plasmid transfer operon protein Thioredoxin_9 PF14595.4 MSTRG.10746.1_1 - 0.034 13.8 0.1 4.1 7.0 0.0 3.0 3 0 0 3 3 3 0 Thioredoxin HyaE PF07449.9 MSTRG.10746.1_1 - 0.13 12.1 0.0 13 5.7 0.0 3.5 3 0 0 3 3 3 0 Hydrogenase-1 expression protein HyaE PFK PF00365.18 MSTRG.10482.1_1 - 4.8e-204 675.5 4.3 2.6e-110 368.1 1.1 2.1 2 0 0 2 2 2 2 Phosphofructokinase T-box PF00907.20 MSTRG.26091.1_1 - 2.5e-63 213.5 0.3 4.4e-63 212.7 0.2 1.4 2 0 0 2 2 2 1 T-box Sushi PF00084.18 MSTRG.25932.1_3 - 1.1e-180 586.2 100.3 3.8e-12 46.5 0.3 18.4 18 0 0 18 18 18 18 Sushi repeat (SCR repeat) EGF_2 PF07974.11 MSTRG.25932.1_3 - 7.2e-11 42.1 53.3 4.7e-05 23.5 5.7 6.9 5 0 0 5 5 5 3 EGF-like domain EGF PF00008.25 MSTRG.25932.1_3 - 1.7e-08 34.4 51.8 3.1e-05 24.1 6.0 7.6 6 0 0 6 6 6 3 EGF-like domain HRM PF02793.20 MSTRG.25932.1_3 - 0.00014 21.9 92.8 0.09 13.0 0.1 16.8 17 1 0 17 17 17 8 Hormone receptor domain hEGF PF12661.5 MSTRG.25932.1_3 - 0.002 18.6 21.5 0.0042 17.6 7.1 9.0 9 0 0 9 9 9 3 Human growth factor-like EGF DUF281 PF03436.11 MSTRG.25932.1_3 - 0.82 10.0 23.4 9 6.7 0.1 8.6 8 0 0 8 8 8 0 Domain of unknown function (DUF281) Ank PF00023.28 MSTRG.21279.2_3 - 7.5e-19 67.2 0.1 0.00014 22.0 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.4 MSTRG.21279.2_3 - 1.8e-18 66.2 0.2 2.1e-07 31.0 0.0 3.6 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 MSTRG.21279.2_3 - 5.4e-18 65.2 0.1 3.7e-11 43.3 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.21279.2_3 - 1.2e-15 57.5 0.0 6.5e-09 36.0 0.0 2.8 1 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.21279.2_3 - 1.2e-14 52.8 0.0 0.00043 20.4 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat Chorion_2 PF03964.13 MSTRG.21279.2_3 - 4 8.2 14.4 37 5.1 14.4 2.7 1 0 0 1 1 1 0 Chorion family 2 SH3-RhoG_link PF16609.3 MSTRG.23019.1_1 - 6.8e-11 42.3 5.5 6.8e-11 42.3 5.5 1.8 1 1 0 2 2 2 1 SH3-RhoGEF linking unstructured region RhoGEF PF00621.18 MSTRG.23019.1_1 - 2.7e-08 34.2 0.0 3.7e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 RhoGEF domain CCDC144C PF14915.4 MSTRG.23232.1_3 - 2.6e-05 23.3 32.4 3e-05 23.2 32.4 1.0 1 0 0 1 1 1 1 CCDC144C protein coiled-coil region Tropomyosin_1 PF12718.5 MSTRG.23232.1_3 - 0.00065 19.7 32.6 0.2 11.7 23.6 2.0 1 1 1 2 2 2 2 Tropomyosin like Tektin PF03148.12 MSTRG.23232.1_3 - 0.022 13.4 25.5 0.089 11.4 17.8 2.0 1 1 1 2 2 2 0 Tektin family CENP-F_leu_zip PF10473.7 MSTRG.23232.1_3 - 0.047 13.6 36.3 0.52 10.2 15.4 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.4 MSTRG.23232.1_3 - 0.048 12.9 33.7 0.012 14.8 21.1 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Metal_resist PF13801.4 MSTRG.23232.1_3 - 0.077 13.0 3.5 0.078 13.0 2.6 1.5 1 1 0 1 1 1 0 Heavy-metal resistance FliJ PF02050.14 MSTRG.23232.1_3 - 0.12 12.5 31.5 0.46 10.6 2.5 2.1 2 0 0 2 2 2 0 Flagellar FliJ protein APG6 PF04111.10 MSTRG.23232.1_3 - 0.18 11.0 30.9 0.1 11.9 28.7 1.5 1 1 1 2 2 2 0 Autophagy protein Apg6 Reo_sigmaC PF04582.10 MSTRG.23232.1_3 - 0.29 10.4 8.9 0.38 10.0 8.9 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF4600 PF15372.4 MSTRG.23232.1_3 - 0.49 10.7 28.5 0.66 10.3 13.5 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4600) CortBP2 PF09727.7 MSTRG.23232.1_3 - 0.69 9.7 30.2 0.35 10.6 4.7 2.1 1 1 1 2 2 2 0 Cortactin-binding protein-2 DUF4164 PF13747.4 MSTRG.23232.1_3 - 0.74 10.0 18.9 1.8 8.8 4.5 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) DUF3618 PF12277.6 MSTRG.23232.1_3 - 0.82 9.8 5.7 1.3 9.1 1.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3618) COG2 PF06148.9 MSTRG.23232.1_3 - 0.95 9.4 17.7 0.85 9.6 16.7 1.4 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 CALCOCO1 PF07888.9 MSTRG.23232.1_3 - 0.96 7.8 27.8 1.2 7.5 27.8 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like HIP1_clath_bdg PF16515.3 MSTRG.23232.1_3 - 0.99 9.9 37.5 0.2 12.2 27.4 2.3 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 IFT57 PF10498.7 MSTRG.23232.1_3 - 1.4 7.7 27.3 1.8 7.3 27.3 1.3 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 DUF1640 PF07798.9 MSTRG.23232.1_3 - 1.6 8.6 29.0 0.1 12.5 14.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) ATG16 PF08614.9 MSTRG.23232.1_3 - 2.5 8.1 36.2 6.1 6.8 25.9 2.1 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Spc7 PF08317.9 MSTRG.23232.1_3 - 2.8 6.6 33.2 1.3 7.7 23.5 1.9 1 1 1 2 2 2 0 Spc7 kinetochore protein Exonuc_VII_L PF02601.13 MSTRG.23232.1_3 - 5.3 6.4 24.0 7.6 5.9 24.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit ADIP PF11559.6 MSTRG.23232.1_3 - 5.4 7.0 37.3 9.6 6.1 26.9 2.7 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF87 PF01935.15 MSTRG.23232.1_3 - 5.9 6.7 11.6 7.1 6.5 11.3 1.3 1 1 0 1 1 1 0 Domain of unknown function DUF87 Uds1 PF15456.4 MSTRG.23232.1_3 - 7.9 6.5 27.5 1.6 8.8 20.1 2.0 1 1 1 2 2 2 0 Up-regulated During Septation Macoilin PF09726.7 MSTRG.23232.1_3 - 8.4 4.7 34.1 9.9 4.4 34.1 1.0 1 0 0 1 1 1 0 Transmembrane protein DUF745 PF05335.11 MSTRG.23232.1_3 - 9.7 5.8 22.3 0.53 9.9 12.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF745) XhlA PF10779.7 MSTRG.23232.1_3 - 9.9 6.3 17.6 0.26 11.4 0.8 3.5 1 1 3 4 4 4 0 Haemolysin XhlA zf-Di19 PF05605.10 MSTRG.26993.1_1 - 3.1e-05 24.0 8.6 6e-05 23.1 8.6 1.4 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-piccolo PF05715.11 MSTRG.26993.1_1 - 0.00015 21.7 0.5 0.00022 21.1 0.5 1.3 1 0 0 1 1 1 1 Piccolo Zn-finger zf-C2H2 PF00096.24 MSTRG.26993.1_1 - 0.00041 20.5 6.8 0.045 14.1 0.6 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_5 PF13909.4 MSTRG.26993.1_1 - 0.00068 19.2 0.2 0.00068 19.2 0.2 2.2 3 0 0 3 3 1 1 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.4 MSTRG.26993.1_1 - 0.0019 18.7 9.5 0.21 12.4 1.0 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger TF_Zn_Ribbon PF08271.10 MSTRG.26993.1_1 - 0.0029 16.9 1.7 0.0075 15.6 1.7 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding Ribosomal_L37ae PF01780.17 MSTRG.26993.1_1 - 0.013 15.4 1.7 0.033 14.2 0.2 2.2 1 1 1 2 2 2 0 Ribosomal L37ae protein family A2L_zn_ribbon PF08792.8 MSTRG.26993.1_1 - 0.014 15.0 0.2 0.014 15.0 0.2 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain zf-met PF12874.5 MSTRG.26993.1_1 - 0.025 14.8 1.5 5.1 7.5 0.0 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type TerY_C PF15616.4 MSTRG.26993.1_1 - 0.043 13.8 0.2 0.067 13.2 0.2 1.3 1 0 0 1 1 1 0 TerY-C metal binding domain zf-C2H2_9 PF16293.3 MSTRG.26993.1_1 - 0.056 13.2 1.7 3.4 7.5 0.2 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (1 copy) Ribosomal_L32p PF01783.21 MSTRG.26993.1_1 - 0.095 12.8 2.7 1.2 9.3 4.0 2.2 2 1 1 3 3 3 0 Ribosomal L32p protein family zf-H2C2_2 PF13465.4 MSTRG.26993.1_1 - 0.17 12.3 10.1 5.4 7.5 0.1 3.5 3 0 0 3 3 3 0 Zinc-finger double domain Prok-RING_4 PF14447.4 MSTRG.26993.1_1 - 0.21 11.4 2.3 3.8 7.3 0.1 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C2H2_2 PF12756.5 MSTRG.26993.1_1 - 0.37 11.0 3.9 3.6 7.9 0.4 2.3 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Zn_Tnp_IS1595 PF12760.5 MSTRG.26993.1_1 - 0.78 9.6 8.9 2.8 7.8 1.6 2.5 1 1 1 2 2 2 0 Transposase zinc-ribbon domain zf-tcix PF14952.4 MSTRG.26993.1_1 - 0.91 9.1 3.7 8.6 5.9 0.0 2.6 3 0 0 3 3 3 0 Putative treble-clef, zinc-finger, Zn-binding zf-ribbon_3 PF13248.4 MSTRG.26993.1_1 - 2.7 7.4 5.0 1.8 7.9 0.8 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Lar_restr_allev PF14354.4 MSTRG.26993.1_1 - 3.1 8.1 6.5 8.7 6.7 6.5 1.7 1 1 0 1 1 1 0 Restriction alleviation protein Lar Myotub-related PF06602.12 MSTRG.8112.1_2 - 1e-137 458.6 0.2 1.3e-137 458.2 0.2 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain 3-PAP PF12578.6 MSTRG.8112.1_2 - 2.7e-05 23.8 0.4 6e-05 22.6 0.4 1.5 1 0 0 1 1 1 1 Myotubularin-associated protein Y_phosphatase PF00102.25 MSTRG.8112.1_2 - 0.0019 17.7 0.0 0.0033 16.9 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.4 MSTRG.8112.1_2 - 0.017 14.9 0.0 0.03 14.1 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family DSPc PF00782.18 MSTRG.8112.1_2 - 0.022 14.4 0.0 0.045 13.4 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain RA PF00788.21 MSTRG.24042.1_3 - 3.6e-11 43.4 0.0 6.8e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain CBFD_NFYB_HMF PF00808.21 MSTRG.5102.2_1 - 2.2e-28 98.2 0.5 3.7e-28 97.5 0.5 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.22 MSTRG.5102.2_1 - 2.6e-05 24.5 0.0 5.7e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.14 MSTRG.5102.2_1 - 0.0077 16.1 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit CENP-T_C PF15511.4 MSTRG.5102.2_1 - 0.0094 15.9 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold NDK PF00334.17 MSTRG.10327.1_1 - 2.3e-38 131.1 0.0 3.4e-38 130.6 0.0 1.3 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Dpy-30 PF05186.11 MSTRG.10327.1_1 - 1.2e-15 56.8 0.2 2.1e-15 56.0 0.2 1.4 1 0 0 1 1 1 1 Dpy-30 motif Integrin_alpha2 PF08441.10 MSTRG.7724.1_2 - 4.6e-87 292.7 0.0 7.4e-87 292.0 0.0 1.3 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.21 MSTRG.7724.1_2 - 2e-22 78.8 12.6 4e-10 39.5 0.0 3.4 3 0 0 3 3 3 3 FG-GAP repeat VCBS PF13517.4 MSTRG.7724.1_2 - 2.7e-09 37.3 6.0 1.5e-07 31.7 0.5 2.6 1 1 1 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.18 MSTRG.7724.1_2 - 0.035 14.0 0.2 0.091 12.7 0.2 1.8 1 0 0 1 1 1 0 Integrin alpha cytoplasmic region CCT_2 PF09425.8 MSTRG.21849.1_3 - 0.059 13.1 1.6 0.12 12.2 0.2 2.0 2 0 0 2 2 2 0 Divergent CCT motif zf-H2C2_2 PF13465.4 MSTRG.19946.1_2 - 2.2e-12 46.7 13.1 2.2e-07 30.9 4.0 4.3 4 0 0 4 4 4 2 Zinc-finger double domain zf-H2C2_5 PF13909.4 MSTRG.19946.1_2 - 1e-11 44.2 22.3 4.8e-05 22.9 0.1 3.3 3 0 0 3 3 3 3 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 MSTRG.19946.1_2 - 5.2e-07 29.6 25.8 0.034 14.5 7.9 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.19946.1_2 - 0.00037 20.9 23.9 0.54 11.1 6.6 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_2 PF12756.5 MSTRG.19946.1_2 - 0.0043 17.2 10.1 0.34 11.1 0.0 3.2 1 1 2 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2_7 PF15269.4 MSTRG.19946.1_2 - 0.0044 16.9 8.6 0.7 9.9 0.5 3.4 1 1 2 3 3 3 2 Zinc-finger AKAP95 PF04988.10 MSTRG.19946.1_2 - 3.2 7.8 9.7 2.6 8.1 0.7 2.8 3 0 0 3 3 3 0 A-kinase anchoring protein 95 (AKAP95) C2 PF00168.28 MSTRG.21683.1_2 - 8.8e-18 64.4 0.0 1.3e-15 57.4 0.0 2.3 2 0 0 2 2 2 2 C2 domain Dimer_Tnp_hAT PF05699.12 MSTRG.21683.1_3 - 3.3e-05 23.5 0.0 9.8e-05 21.9 0.0 1.8 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region zf-H2C2_2 PF13465.4 MSTRG.4988.1_3 - 2.5e-48 160.3 70.9 1.2e-09 38.0 0.8 10.9 12 0 0 12 12 11 7 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.4988.1_3 - 1.5e-40 135.3 56.9 6.7e-06 26.1 1.4 8.6 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.4988.1_3 - 5.6e-33 110.6 54.4 0.00028 21.3 0.7 8.7 8 0 0 8 8 8 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.4988.1_3 - 1e-20 73.1 46.7 0.0017 18.1 0.7 9.0 8 0 0 8 8 8 6 C2H2-type zinc finger zf-Di19 PF05605.10 MSTRG.4988.1_3 - 2.5e-12 46.8 33.1 0.00067 19.8 2.1 5.1 4 1 1 5 5 5 5 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.5 MSTRG.4988.1_3 - 3.2e-12 46.3 53.2 0.0028 17.9 2.4 8.2 8 0 0 8 8 8 6 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.4 MSTRG.4988.1_3 - 1.9e-10 40.2 32.6 0.15 11.7 0.2 7.8 7 0 0 7 7 7 6 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.6 MSTRG.4988.1_3 - 9.3e-06 25.7 27.0 0.99 9.7 0.6 7.5 7 0 0 7 7 7 3 Zinc-finger double-stranded RNA-binding Elf1 PF05129.11 MSTRG.4988.1_3 - 2.6e-05 24.0 31.9 0.055 13.4 0.7 5.5 1 1 4 5 5 5 3 Transcription elongation factor Elf1 like zf-C2H2_2 PF12756.5 MSTRG.4988.1_3 - 0.00015 21.9 39.6 1.4 9.2 0.1 7.3 1 1 3 5 5 5 3 C2H2 type zinc-finger (2 copies) zf-BED PF02892.13 MSTRG.4988.1_3 - 0.00095 19.0 51.6 0.86 9.6 1.2 7.9 3 1 4 7 7 7 5 BED zinc finger zinc_ribbon_15 PF17032.3 MSTRG.4988.1_3 - 0.0093 16.6 25.3 2.3 8.9 2.8 5.4 1 1 4 5 5 5 2 zinc-ribbon family HAP1_N PF04849.11 MSTRG.4988.1_3 - 0.01 15.0 1.4 0.016 14.3 1.4 1.3 1 0 0 1 1 1 0 HAP1 N-terminal conserved region PHD_4 PF16866.3 MSTRG.4988.1_3 - 0.034 14.1 24.0 2.5 8.2 0.5 5.6 1 1 4 6 6 6 0 PHD-finger zf-Sec23_Sec24 PF04810.13 MSTRG.4988.1_3 - 0.045 13.7 26.6 8.6 6.4 0.1 7.7 4 3 4 8 8 8 0 Sec23/Sec24 zinc finger LIM PF00412.20 MSTRG.4988.1_3 - 0.14 12.3 32.4 7 6.8 3.1 7.2 2 1 6 8 8 8 0 LIM domain zf-C4_ClpX PF06689.11 MSTRG.4988.1_3 - 0.14 11.9 0.1 0.14 11.9 0.1 8.3 9 0 0 9 9 8 0 ClpX C4-type zinc finger C1_2 PF03107.14 MSTRG.4988.1_3 - 0.29 11.3 44.2 2.7 8.3 0.5 9.0 2 1 6 9 9 9 0 C1 domain TerY_C PF15616.4 MSTRG.4988.1_3 - 0.43 10.6 18.8 1.3 9.1 0.4 3.9 1 1 3 5 5 5 0 TerY-C metal binding domain DUF2256 PF10013.7 MSTRG.4988.1_3 - 0.69 10.0 18.9 24 5.0 0.0 6.8 7 0 0 7 7 6 0 Uncharacterized protein conserved in bacteria (DUF2256) Zn_Tnp_IS1595 PF12760.5 MSTRG.4988.1_3 - 0.79 9.6 28.7 1.6 8.6 0.9 5.2 3 1 0 4 4 4 0 Transposase zinc-ribbon domain FdhE PF04216.10 MSTRG.4988.1_3 - 0.83 9.3 15.0 1.3 8.7 0.3 3.6 1 1 1 3 3 3 0 Protein involved in formate dehydrogenase formation Zn-ribbon_8 PF09723.8 MSTRG.4988.1_3 - 7.9 6.6 31.8 2.7 8.1 0.3 6.7 3 1 3 6 6 5 0 Zinc ribbon domain zf-AN1 PF01428.14 MSTRG.4988.1_3 - 8.8 6.5 35.8 3.6 7.7 0.2 8.5 7 1 1 8 8 8 0 AN1-like Zinc finger CpXC PF14353.4 MSTRG.4988.1_3 - 10 6.1 24.8 3.4 7.6 0.1 7.3 3 2 2 6 6 6 0 CpXC protein Gln-synt_C PF00120.22 MSTRG.12726.1_2 - 4.6e-17 61.9 0.0 1.6e-11 43.7 0.0 2.2 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.17 MSTRG.12726.1_2 - 4.3e-14 51.9 0.0 7.8e-14 51.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Vinculin PF01044.17 MSTRG.7331.2_2 - 0 1012.8 36.8 6e-211 703.2 22.9 2.0 1 1 1 2 2 2 2 Vinculin family Cyclin_N PF00134.21 MSTRG.17790.2_3 - 6.3e-30 103.4 1.5 1.2e-29 102.5 1.5 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 MSTRG.17790.2_3 - 8.1e-13 48.4 0.4 1.9e-12 47.2 0.0 1.8 2 0 0 2 2 2 1 Cyclin, C-terminal domain YejG PF13989.4 MSTRG.17790.2_3 - 0.048 13.9 0.2 0.11 12.7 0.2 1.6 1 0 0 1 1 1 0 YejG-like protein UQ_con PF00179.24 MSTRG.5450.1_1 - 3e-23 81.9 0.1 5.6e-23 81.0 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Mito_carr PF00153.25 MSTRG.20765.1_1 - 6.5e-61 202.2 1.0 1.6e-21 75.9 0.1 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein YqzE PF14038.4 MSTRG.1502.1_1 - 0.089 12.7 1.7 0.2 11.6 1.2 1.9 2 0 0 2 2 2 0 YqzE-like protein NUDIX PF00293.26 MSTRG.25330.1_3 - 6.5e-23 81.1 0.0 1e-22 80.4 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain GHL10 PF02638.13 MSTRG.25330.1_3 - 0.06 12.3 0.1 0.093 11.7 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase-like 10 Flavodoxin_2 PF02525.15 MSTRG.5944.2_3 - 1.2e-48 165.4 0.0 1.7e-48 164.9 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.13 MSTRG.5944.2_3 - 2.3e-08 33.8 0.0 4.3e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase DLH PF01738.16 MSTRG.5944.2_3 - 0.029 13.8 0.0 0.23 10.8 0.0 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family Aconitase_C PF00694.17 MSTRG.5944.2_3 - 0.038 14.2 0.0 0.069 13.4 0.0 1.3 1 0 0 1 1 1 0 Aconitase C-terminal domain Flavodoxin_4 PF12682.5 MSTRG.5944.2_3 - 0.09 12.3 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Flavodoxin Pkinase PF00069.23 MSTRG.9399.2_2 - 2.8e-72 243.1 0.0 4.1e-72 242.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.9399.2_2 - 1.6e-45 155.3 0.0 2.7e-45 154.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 MSTRG.9399.2_2 - 1.2e-23 83.2 0.0 4e-23 81.4 0.0 2.0 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 MSTRG.9399.2_2 - 8.7e-08 31.7 0.2 0.00018 20.8 0.0 3.0 2 1 1 3 3 3 2 Kinase-like Spt5_N PF11942.6 MSTRG.9399.2_2 - 0.0012 19.7 7.8 0.0026 18.6 7.8 1.5 1 0 0 1 1 1 1 Spt5 transcription elongation factor, acidic N-terminal DSHCT PF08148.10 MSTRG.9399.2_2 - 0.015 14.8 0.0 0.029 13.9 0.0 1.5 1 0 0 1 1 1 0 DSHCT (NUC185) domain APH PF01636.21 MSTRG.9399.2_2 - 0.016 15.0 0.1 0.084 12.6 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Ribosomal_60s PF00428.17 MSTRG.9399.2_2 - 0.019 15.3 10.4 0.019 15.3 10.4 1.7 2 0 0 2 2 1 0 60s Acidic ribosomal protein DUF2052 PF09747.7 MSTRG.9399.2_2 - 0.028 14.4 5.6 0.049 13.6 5.6 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Kdo PF06293.12 MSTRG.9399.2_2 - 0.059 12.6 0.0 0.14 11.4 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family RNA_pol_3_Rpc31 PF11705.6 MSTRG.9399.2_2 - 0.11 12.6 10.0 0.013 15.6 5.5 1.7 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 CDC45 PF02724.12 MSTRG.9399.2_2 - 0.14 10.3 3.5 0.21 9.7 3.5 1.2 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.8 MSTRG.9399.2_2 - 0.17 12.2 9.5 0.32 11.3 9.5 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain EBV-NA3 PF05009.10 MSTRG.9399.2_2 - 0.8 9.0 3.1 1.3 8.3 3.1 1.3 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) Astro_capsid_p PF12226.6 MSTRG.9399.2_2 - 0.91 8.5 7.1 2 7.4 7.1 1.5 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DNA_pol_phi PF04931.11 MSTRG.9399.2_2 - 1.3 6.9 7.2 2.1 6.2 7.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.10 MSTRG.9399.2_2 - 4.8 6.3 6.4 7.9 5.6 6.4 1.2 1 0 0 1 1 1 0 NOA36 protein PGA2 PF07543.10 MSTRG.9399.2_2 - 6.2 6.7 8.9 0.74 9.7 3.7 2.0 2 0 0 2 2 2 0 Protein trafficking PGA2 RXT2_N PF08595.9 MSTRG.9399.2_2 - 8.3 6.3 8.9 7.7 6.4 6.9 1.9 1 1 0 1 1 1 0 RXT2-like, N-terminal Ion_trans PF00520.29 MSTRG.5165.3_2 - 4.1e-42 144.0 13.3 6e-42 143.4 13.3 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.14 MSTRG.5165.3_2 - 7.6e-10 38.5 4.3 7.6e-10 38.5 4.3 2.6 2 0 0 2 2 2 1 Ion channel zf-C2H2 PF00096.24 MSTRG.17184.1_3 - 2.2e-31 106.4 90.8 3e-05 24.1 0.6 13.1 12 0 0 12 12 12 10 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.17184.1_3 - 6.3e-27 92.6 71.5 2.4e-08 33.9 0.1 12.3 12 0 0 12 12 12 7 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.17184.1_3 - 1.8e-18 65.5 88.0 0.0078 16.8 0.8 13.3 13 0 0 13 13 12 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.17184.1_3 - 1.3e-06 28.1 64.8 0.012 15.4 0.5 11.5 11 0 0 11 11 11 5 C2H2-type zinc finger zf-Di19 PF05605.10 MSTRG.17184.1_3 - 0.0028 17.8 33.0 0.015 15.5 0.1 7.6 7 1 1 8 8 8 3 Drought induced 19 protein (Di19), zinc-binding DZR PF12773.5 MSTRG.17184.1_3 - 0.0038 17.1 30.2 0.026 14.4 1.1 7.3 4 2 1 5 5 5 2 Double zinc ribbon zf-C2H2_jaz PF12171.6 MSTRG.17184.1_3 - 0.015 15.5 0.2 0.015 15.5 0.2 9.9 11 0 0 11 11 10 0 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.4 MSTRG.17184.1_3 - 0.027 14.2 0.3 0.027 14.2 0.3 8.3 8 0 0 8 8 8 0 zinc-finger of a C2HC-type PyrI_C PF02748.13 MSTRG.17184.1_3 - 1.7 8.5 19.8 12 5.8 0.0 7.1 8 0 0 8 8 8 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_9 PF16293.3 MSTRG.17184.1_3 - 3.1 7.6 9.5 2.2 8.1 0.1 4.7 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) zf-met PF12874.5 MSTRG.17184.1_3 - 7.4 7.0 46.6 1 9.7 0.1 8.9 9 0 0 9 9 9 0 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.4 MSTRG.13705.3_1 - 5.3e-38 127.7 49.3 3.5e-09 36.6 0.5 7.7 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.13705.3_1 - 6.7e-34 114.3 49.7 5.9e-06 26.3 0.3 7.8 7 0 0 7 7 7 7 Zinc finger, C2H2 type BTB PF00651.29 MSTRG.13705.3_1 - 1e-26 93.2 3.2 2.4e-26 92.0 0.4 2.3 2 0 0 2 2 2 1 BTB/POZ domain zf-C2H2_4 PF13894.4 MSTRG.13705.3_1 - 2.6e-20 71.2 48.6 0.00059 20.3 0.3 7.9 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.13705.3_1 - 5.9e-15 54.7 44.0 0.00072 19.3 0.2 7.7 7 0 0 7 7 7 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.13705.3_1 - 7.7e-14 51.4 27.9 0.091 13.0 1.8 7.8 7 0 0 7 7 7 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.13705.3_1 - 1e-13 51.1 36.9 0.0018 18.4 1.7 8.1 7 0 0 7 7 7 6 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.8 MSTRG.13705.3_1 - 0.00012 22.0 25.8 0.06 13.3 1.5 5.2 3 1 2 5 5 5 2 Zinc ribbon domain zf-C2H2_11 PF16622.3 MSTRG.13705.3_1 - 0.0041 16.7 31.2 0.51 10.0 1.0 6.3 6 0 0 6 6 6 4 zinc-finger C2H2-type GAGA PF09237.9 MSTRG.13705.3_1 - 0.0047 16.6 7.3 0.28 10.9 0.1 4.6 3 2 1 5 5 5 1 GAGA factor Ta0938 PF11494.6 MSTRG.13705.3_1 - 0.07 13.3 8.6 0.15 12.3 0.3 3.6 1 1 1 3 3 3 0 Ta0938 zinc_ribbon_15 PF17032.3 MSTRG.13705.3_1 - 0.14 12.8 19.3 3.9 8.2 2.4 4.5 1 1 0 3 3 3 0 zinc-ribbon family DUF3268 PF11672.6 MSTRG.13705.3_1 - 0.65 10.2 17.4 3.2 8.0 0.4 4.2 4 1 1 5 5 5 0 zinc-finger-containing domain ADK_lid PF05191.12 MSTRG.13705.3_1 - 8.6 6.4 28.7 0.41 10.6 1.3 4.7 4 0 0 4 4 4 0 Adenylate kinase, active site lid zf-C2HC_2 PF13913.4 MSTRG.13705.3_1 - 8.8 6.2 35.3 0.85 9.5 0.3 7.3 7 0 0 7 7 7 0 zinc-finger of a C2HC-type PTH2 PF01981.14 MSTRG.22782.1_3 - 9.4e-44 148.3 0.0 1.3e-43 147.8 0.0 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Romo1 PF10247.7 MSTRG.22782.1_3 - 0.052 13.7 1.8 0.34 11.1 2.1 2.2 2 1 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 PH PF00169.27 MSTRG.3510.1_3 - 1.2e-22 80.3 0.0 1.8e-11 44.4 0.0 2.4 2 0 0 2 2 2 2 PH domain ArfGap PF01412.16 MSTRG.3510.1_3 - 2.9e-13 49.7 0.2 5.5e-13 48.8 0.2 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH_11 PF15413.4 MSTRG.3510.1_3 - 1.2e-06 28.7 0.3 0.0001 22.5 0.0 3.1 2 2 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.4 MSTRG.3510.1_3 - 7.3e-05 22.8 0.9 0.15 12.2 0.1 2.9 3 0 0 3 3 3 2 Pleckstrin homology domain PH_3 PF14593.4 MSTRG.3510.1_3 - 0.0099 15.8 0.0 0.17 11.9 0.0 2.4 1 1 0 1 1 1 1 PH domain BET PF17035.3 MSTRG.16804.3_2 - 1.1e-29 102.3 0.1 1.8e-29 101.5 0.1 1.4 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation Bromodomain PF00439.23 MSTRG.16804.3_2 - 9.8e-20 70.3 0.2 1.5e-19 69.7 0.2 1.3 1 0 0 1 1 1 1 Bromodomain TAF4 PF05236.12 MSTRG.16804.3_2 - 0.00013 21.7 10.8 0.00013 21.7 10.8 2.2 2 0 0 2 2 2 1 Transcription initiation factor TFIID component TAF4 family AF-4 PF05110.11 MSTRG.16804.3_2 - 0.00093 17.3 16.1 0.00093 17.3 16.1 2.1 2 0 0 2 2 2 1 AF-4 proto-oncoprotein DUF4887 PF16228.3 MSTRG.16804.3_2 - 0.54 10.0 25.8 1 9.2 25.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4887) SRP-alpha_N PF04086.11 MSTRG.16804.3_2 - 3.6 7.3 26.7 0.25 11.1 20.2 2.0 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal Ins134_P3_kin PF05770.9 MSTRG.7546.2_1 - 1.2e-121 405.6 0.1 1.4e-121 405.4 0.1 1.0 1 0 0 1 1 1 1 Inositol 1, 3, 4-trisphosphate 5/6-kinase TSP_C PF05735.10 MSTRG.15295.1_2 - 1.4e-12 47.8 0.1 1.8e-12 47.5 0.1 1.1 1 0 0 1 1 1 1 Thrombospondin C-terminal region EF-hand_6 PF13405.4 MSTRG.2364.1_3 - 0.02 14.7 0.0 0.035 13.9 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain RhoGEF PF00621.18 MSTRG.22043.1_2 - 1.9e-23 83.5 1.5 2.2e-23 83.3 0.2 1.8 2 0 0 2 2 2 1 RhoGEF domain DUF4675 PF15720.3 MSTRG.22043.1_2 - 9.6e-12 44.9 2.3 2.1e-11 43.8 2.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4675) PH_13 PF16652.3 MSTRG.22043.1_2 - 2.2e-07 30.7 0.1 6.1e-07 29.3 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_5 PF15405.4 MSTRG.22043.1_2 - 0.00031 20.7 0.7 0.0035 17.3 0.3 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.27 MSTRG.22043.1_2 - 0.0075 16.6 0.1 0.023 15.0 0.1 1.9 1 1 0 1 1 1 1 PH domain PH_10 PF15411.4 MSTRG.22043.1_2 - 0.046 13.8 0.0 0.13 12.4 0.0 1.8 1 1 0 1 1 1 0 Pleckstrin homology domain WD40 PF00400.30 MSTRG.15889.3_2 - 2.4e-37 126.1 7.6 5.3e-08 33.3 0.2 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.15889.3_2 - 4.1e-17 62.1 0.1 1.9e-05 24.8 0.0 4.9 1 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 MSTRG.15889.3_2 - 1.5e-14 53.6 0.7 0.00052 18.9 0.0 3.4 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.6 MSTRG.15889.3_2 - 7.5e-09 34.6 0.1 0.0012 17.4 0.0 3.3 1 1 2 3 3 3 2 Nucleoporin Nup120/160 LisH PF08513.9 MSTRG.15889.3_2 - 0.0081 16.0 0.0 0.018 14.9 0.0 1.6 1 0 0 1 1 1 1 LisH Hira PF07569.9 MSTRG.15889.3_2 - 0.012 15.2 0.9 7.7 6.1 0.0 4.2 5 0 0 5 5 5 0 TUP1-like enhancer of split PD40 PF07676.10 MSTRG.15889.3_2 - 0.036 13.9 0.0 1.3 8.9 0.0 3.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Nbas_N PF15492.4 MSTRG.15889.3_2 - 0.086 12.0 0.1 1.1 8.3 0.0 2.5 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal PMP22_Claudin PF00822.18 MSTRG.13533.1_3 - 2.3e-06 27.4 9.4 2.3e-06 27.4 9.4 1.8 2 0 0 2 2 2 1 PMP-22/EMP/MP20/Claudin family Clc-like PF07062.10 MSTRG.13533.1_3 - 0.025 13.9 12.2 0.44 9.8 0.4 2.3 1 1 0 2 2 2 0 Clc-like Pirin_C PF05726.11 MSTRG.17492.1_3 - 1.6e-34 118.3 0.0 2.3e-33 114.5 0.0 2.4 3 0 0 3 3 3 1 Pirin C-terminal cupin domain Pirin PF02678.14 MSTRG.17492.1_3 - 1.3e-32 111.8 0.0 2.2e-32 111.1 0.0 1.4 1 0 0 1 1 1 1 Pirin Cupin_2 PF07883.9 MSTRG.17492.1_3 - 3.8e-08 32.8 1.9 0.005 16.4 0.1 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.10 MSTRG.17492.1_3 - 0.0019 17.6 0.3 0.53 9.8 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF861) PHD PF00628.27 MSTRG.13114.2_1 - 1.8e-06 27.6 11.1 6.8e-06 25.8 11.1 2.1 1 0 0 1 1 1 1 PHD-finger MBT PF02820.16 MSTRG.13114.2_1 - 0.00014 22.0 0.0 0.00048 20.3 0.0 1.9 1 0 0 1 1 1 1 mbt repeat DUF4537 PF15057.4 MSTRG.13114.2_1 - 0.00032 20.5 0.0 0.0007 19.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) Agenet PF05641.10 MSTRG.13114.2_1 - 0.0047 17.2 2.2 2.7 8.4 0.3 2.7 2 0 0 2 2 2 2 Agenet domain zf-C2H2 PF00096.24 MSTRG.13114.2_1 - 0.012 15.9 3.4 0.049 14.0 3.4 2.2 1 0 0 1 1 1 0 Zinc finger, C2H2 type DUF1325 PF07039.9 MSTRG.13114.2_1 - 0.024 14.6 0.0 0.055 13.4 0.0 1.6 1 0 0 1 1 1 0 SGF29 tudor-like domain Tudor-knot PF11717.6 MSTRG.13114.2_1 - 0.044 13.6 6.0 0.41 10.5 2.8 3.2 4 0 0 4 4 4 0 RNA binding activity-knot of a chromodomain Pox_RNA_pol PF03293.12 MSTRG.13114.2_1 - 4.9 6.7 5.0 6.9 6.2 1.5 2.3 2 0 0 2 2 2 0 Poxvirus DNA-directed RNA polymerase, 18 kD subunit MatE PF01554.16 MSTRG.21164.1_3 - 7.2e-10 38.6 0.2 7.2e-10 38.6 0.2 1.7 2 0 0 2 2 2 1 MatE TSKS PF15358.4 MSTRG.21164.1_3 - 0.023 13.0 0.1 0.03 12.6 0.1 1.1 1 0 0 1 1 1 0 Testis-specific serine kinase substrate Polysacc_synt_C PF14667.4 MSTRG.21164.1_3 - 1.5 8.7 10.6 0.1 12.6 2.8 2.3 3 0 0 3 3 3 0 Polysaccharide biosynthesis C-terminal domain WD40 PF00400.30 MSTRG.13551.2_1 - 7.5e-38 127.7 18.4 4.6e-05 24.0 0.1 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.13551.2_1 - 2.3e-12 46.9 0.0 0.0034 17.5 0.0 5.2 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 MSTRG.13551.2_1 - 0.00012 21.4 0.0 0.0046 16.2 0.0 2.2 1 1 1 2 2 2 2 WD40-like domain CALM_bind PF16025.3 MSTRG.13551.2_1 - 0.091 13.1 0.2 0.18 12.1 0.2 1.4 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding Spectrin PF00435.19 MSTRG.26787.1_1 - 9.5e-06 25.9 2.9 9.5e-06 25.9 2.9 2.3 1 1 1 2 2 2 1 Spectrin repeat MDM31_MDM32 PF08118.9 MSTRG.26787.1_1 - 0.0021 16.7 0.2 0.0025 16.4 0.2 1.1 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins LIAS_N PF16881.3 MSTRG.26787.1_1 - 0.079 13.2 0.1 0.2 12.0 0.0 1.7 1 1 1 2 2 2 0 N-terminal domain of lipoyl synthase of Radical_SAM family DUF3826 PF12875.5 MSTRG.26787.1_1 - 0.083 12.9 3.7 0.13 12.2 3.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3826) Seryl_tRNA_N PF02403.20 MSTRG.26787.1_1 - 0.087 12.9 4.5 3 8.0 0.1 2.9 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Ebp2 PF05890.10 MSTRG.26787.1_1 - 0.28 10.6 2.3 0.39 10.1 2.3 1.1 1 0 0 1 1 1 0 Eukaryotic rRNA processing protein EBP2 MukB_hinge PF16330.3 MSTRG.26787.1_1 - 0.54 9.8 6.6 0.68 9.5 0.9 2.2 2 0 0 2 2 2 0 MukB hinge domain COG2 PF06148.9 MSTRG.26787.1_1 - 1.7 8.6 9.8 0.71 9.8 2.0 2.3 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1664 PF07889.10 MSTRG.26787.1_1 - 4.6 7.1 8.0 20 5.1 7.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) PCRF PF03462.16 MSTRG.26787.1_1 - 5.3 6.7 9.8 6.1 6.5 3.1 2.0 1 1 1 2 2 2 0 PCRF domain STAT_bind PF02864.13 MSTRG.11787.2_1 - 6.1e-72 242.4 1.2 6.1e-72 242.4 1.2 2.0 2 0 0 2 2 2 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 MSTRG.11787.2_1 - 5.3e-51 172.9 13.4 5.3e-51 172.9 13.4 1.9 2 0 0 2 2 2 1 STAT protein, all-alpha domain STAT_int PF02865.15 MSTRG.11787.2_1 - 1.4e-36 125.5 2.5 1.4e-36 125.5 2.5 2.7 3 0 0 3 3 3 1 STAT protein, protein interaction domain SH2 PF00017.22 MSTRG.11787.2_1 - 3e-09 36.7 0.0 6.8e-09 35.5 0.0 1.6 1 0 0 1 1 1 1 SH2 domain STAT1_TAZ2bind PF12162.6 MSTRG.11787.2_1 - 1.5e-06 27.5 1.5 3.2e-06 26.5 1.5 1.6 1 0 0 1 1 1 1 STAT1 TAZ2 binding domain Thioredoxin_6 PF13848.4 MSTRG.20820.1_3 - 4.1e-45 153.9 1.3 6.6e-40 136.9 0.3 2.2 2 0 0 2 2 2 2 Thioredoxin-like domain Thioredoxin PF00085.18 MSTRG.20820.1_3 - 1.1e-19 70.1 0.0 2.2e-19 69.1 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Calsequestrin PF01216.15 MSTRG.20820.1_3 - 5.5e-09 35.4 0.1 8.2e-09 34.8 0.1 1.2 1 0 0 1 1 1 1 Calsequestrin HyaE PF07449.9 MSTRG.20820.1_3 - 6.8e-05 22.7 0.0 0.00015 21.5 0.0 1.5 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE OST3_OST6 PF04756.11 MSTRG.20820.1_3 - 0.00058 19.2 0.1 0.0011 18.2 0.1 1.4 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.4 MSTRG.20820.1_3 - 0.046 14.0 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like domain Spectrin PF00435.19 MSTRG.324.1_2 - 0 1502.6 242.2 6.5e-29 100.4 3.2 23.2 23 0 0 23 23 23 22 Spectrin repeat EFhand_Ca_insen PF08726.8 MSTRG.324.1_2 - 4.9e-27 93.7 1.6 2.7e-24 84.9 0.3 4.2 3 0 0 3 3 3 1 Ca2+ insensitive EF hand SH3_1 PF00018.26 MSTRG.324.1_2 - 9.1e-15 53.9 0.1 2.3e-14 52.5 0.1 1.8 1 0 0 1 1 1 1 SH3 domain EF-hand_1 PF00036.30 MSTRG.324.1_2 - 1.2e-11 43.1 0.3 9.2e-06 24.7 0.1 3.2 2 0 0 2 2 2 2 EF hand SH3_9 PF14604.4 MSTRG.324.1_2 - 3.2e-11 42.8 0.0 9.2e-11 41.3 0.0 1.8 2 0 0 2 2 1 1 Variant SH3 domain EF-hand_7 PF13499.4 MSTRG.324.1_2 - 9.4e-11 41.9 0.9 1.1e-08 35.2 0.0 4.1 2 1 1 3 3 2 1 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.324.1_2 - 1e-08 34.3 0.3 0.00056 19.5 0.1 5.0 4 0 0 4 4 4 1 EF-hand domain EF-hand_8 PF13833.4 MSTRG.324.1_2 - 4.4e-08 32.6 0.0 0.043 13.5 0.1 3.7 3 0 0 3 3 3 2 EF-hand domain pair SH3_2 PF07653.15 MSTRG.324.1_2 - 3.1e-07 29.9 0.0 2.6e-06 26.9 0.0 2.3 2 0 0 2 2 2 1 Variant SH3 domain Peroxidase_2 PF01328.15 MSTRG.324.1_2 - 0.00024 20.2 0.7 0.019 14.0 0.2 2.5 2 0 0 2 2 2 1 Peroxidase, family 2 GvpG PF05120.10 MSTRG.324.1_2 - 0.00024 20.9 6.7 2 8.3 0.1 5.0 3 0 0 3 3 3 2 Gas vesicle protein G EF-hand_5 PF13202.4 MSTRG.324.1_2 - 0.00095 18.5 0.0 2.2 7.8 0.0 3.5 2 0 0 2 2 2 2 EF hand RecG_N PF17190.2 MSTRG.324.1_2 - 0.22 12.1 0.0 0.22 12.1 0.0 9.2 8 1 1 9 9 8 0 RecG N-terminal helical domain Surfac_D-trimer PF09006.9 MSTRG.324.1_2 - 0.75 9.6 6.0 21 5.0 0.0 5.1 5 0 0 5 5 5 0 Lung surfactant protein D coiled-coil trimerisation SnoaL_3 PF13474.4 MSTRG.324.1_2 - 9.1 6.5 6.7 20 5.4 0.0 4.4 5 0 0 5 5 5 0 SnoaL-like domain RhoGEF PF00621.18 MSTRG.528.3_2 - 6.5e-33 114.4 0.0 1.6e-32 113.1 0.0 1.7 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 MSTRG.528.3_2 - 0.0016 18.8 0.0 0.0033 17.8 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_13 PF16652.3 MSTRG.528.3_2 - 0.0034 17.1 0.2 0.051 13.3 0.2 2.7 1 1 0 1 1 1 1 Pleckstrin homology domain PH_5 PF15405.4 MSTRG.528.3_2 - 0.0054 16.7 0.0 0.012 15.6 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_10 PF15411.4 MSTRG.528.3_2 - 0.033 14.3 0.8 0.081 13.1 0.1 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain ATG_C PF09333.9 MSTRG.3399.1_1 - 1.4e-28 99.0 0.0 4e-28 97.5 0.0 1.9 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Chorein_N PF12624.5 MSTRG.3399.1_1 - 3.3e-15 56.1 0.0 1.2e-14 54.3 0.0 2.0 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 ATG2_CAD PF13329.4 MSTRG.3399.1_1 - 5.7e-06 26.0 0.2 1.2e-05 25.0 0.2 1.5 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif VPS13_C PF16909.3 MSTRG.3399.1_1 - 2.8e-05 23.8 0.0 0.00016 21.3 0.0 2.2 3 0 0 3 3 3 1 Vacuolar-sorting-associated 13 protein C-terminal DEAD_2 PF06733.13 MSTRG.21188.2_2 - 2.1e-51 173.9 0.1 3.5e-51 173.2 0.1 1.3 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.4 MSTRG.21188.2_2 - 2.5e-46 157.8 0.1 5.6e-46 156.7 0.1 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain HBB PF06777.9 MSTRG.21188.2_2 - 7.3e-46 156.1 0.8 4e-40 137.4 0.2 2.6 2 0 0 2 2 2 2 Helical and beta-bridge domain ResIII PF04851.13 MSTRG.21188.2_2 - 0.00048 20.1 0.1 0.33 10.8 0.0 2.8 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit SesA PF17107.3 MSTRG.21188.2_2 - 0.0018 18.3 0.5 0.079 13.0 0.1 3.1 3 0 0 3 3 3 1 N-terminal domain on NACHT_NTPase and P-loop NTPases CNH PF00780.20 MSTRG.12480.5_2 - 2e-58 198.0 0.0 3.3e-58 197.3 0.0 1.4 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.23 MSTRG.12480.5_2 - 5.3e-19 68.5 0.0 9.2e-19 67.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.12480.5_2 - 4.5e-11 42.4 0.0 7.4e-11 41.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase FYVE PF01363.19 MSTRG.28574.1_1 - 0.015 15.3 1.9 0.026 14.5 1.9 1.4 1 0 0 1 1 1 0 FYVE zinc finger DZR PF12773.5 MSTRG.28574.1_1 - 3.7 7.5 8.4 0.77 9.7 4.9 1.7 2 1 0 2 2 2 0 Double zinc ribbon EST1_DNA_bind PF10373.7 MSTRG.10418.3_1 - 1.2e-47 162.6 0.5 1.2e-47 162.6 0.5 1.8 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.7 MSTRG.10418.3_1 - 1.2e-25 90.6 0.1 4.9e-25 88.6 0.0 2.2 2 0 0 2 2 2 1 Telomerase activating protein Est1 TPR_7 PF13176.4 MSTRG.10418.3_1 - 0.0072 16.2 0.0 0.4 10.7 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat zf-AD PF07776.13 MSTRG.10418.3_1 - 0.015 15.3 0.2 0.049 13.7 0.2 1.9 1 1 0 1 1 1 0 Zinc-finger associated domain (zf-AD) TPR_2 PF07719.15 MSTRG.10418.3_1 - 0.077 13.0 0.0 0.22 11.6 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat RabGAP-TBC PF00566.16 MSTRG.14243.1_1 - 6.2e-47 159.9 1.5 9.2e-47 159.3 1.5 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF3548 PF12068.6 MSTRG.14243.1_1 - 3.6e-06 26.6 0.7 0.0011 18.5 0.1 2.7 2 1 1 3 3 3 2 Domain of unknown function (DUF3548) Peptidase_C2 PF00648.19 MSTRG.15542.4_1 - 2.4e-81 272.9 0.0 3.2e-81 272.5 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease zf-RanBP PF00641.16 MSTRG.15542.4_1 - 9.7e-21 72.7 74.7 2.3e-05 23.5 1.2 8.2 9 0 0 9 9 9 6 Zn-finger in Ran binding protein and others zf-MYND PF01753.16 MSTRG.15542.4_3 - 1.3e-08 34.6 18.5 5.7e-08 32.6 18.5 2.2 1 0 0 1 1 1 1 MYND finger zf-Mss51 PF13824.4 MSTRG.15542.4_3 - 2.7 8.1 6.6 7 6.7 6.6 1.8 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Vps5 PF09325.8 MSTRG.17598.2_2 - 4e-80 268.6 19.8 5.7e-80 268.1 19.8 1.2 1 0 0 1 1 1 1 Vps5 C terminal like Sorting_nexin PF03700.11 MSTRG.17598.2_2 - 1.3e-30 106.4 8.9 2.6e-30 105.5 8.9 1.5 1 0 0 1 1 1 1 Sorting nexin, N-terminal domain PX PF00787.22 MSTRG.17598.2_2 - 8.6e-25 86.8 0.2 2e-24 85.6 0.0 1.7 2 0 0 2 2 2 1 PX domain BAR_3_WASP_bdg PF10456.7 MSTRG.17598.2_2 - 0.0025 17.2 5.2 0.13 11.5 5.2 2.2 1 1 0 1 1 1 1 WASP-binding domain of Sorting nexin protein DUF4398 PF14346.4 MSTRG.17598.2_2 - 0.046 14.3 3.3 0.21 12.2 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4398) FAM92 PF06730.9 MSTRG.17598.2_2 - 0.059 12.7 7.8 0.92 8.7 7.8 2.1 1 1 0 1 1 1 0 FAM92 protein BAR_3 PF16746.3 MSTRG.17598.2_2 - 1 8.9 11.5 7.5 6.0 10.7 2.2 1 1 1 2 2 2 0 BAR domain of APPL family DUF310 PF03750.11 MSTRG.17598.2_2 - 1.1 10.0 5.2 13 6.6 1.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF310) DUF342 PF03961.11 MSTRG.17598.2_2 - 2.5 6.5 9.0 4.3 5.7 1.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF342) YgaB PF14182.4 MSTRG.17598.2_2 - 4.8 7.6 11.9 0.22 11.9 1.3 3.0 2 2 2 4 4 4 0 YgaB-like protein CCDC-167 PF15188.4 MSTRG.17598.2_2 - 8.3 6.7 7.9 7.6 6.8 1.8 3.2 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 167 TIR PF01582.18 MSTRG.5546.1_1 - 2.7e-12 46.7 0.1 7.4e-12 45.3 0.1 1.7 1 1 0 1 1 1 1 TIR domain Death PF00531.20 MSTRG.5546.1_1 - 4.7e-11 42.6 0.5 7.8e-11 41.9 0.0 1.7 2 0 0 2 2 2 1 Death domain TIR_2 PF13676.4 MSTRG.5546.1_1 - 6.8e-11 42.3 0.0 1.1e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 TIR domain WD40 PF00400.30 MSTRG.15139.1_2 - 2.4e-05 24.9 0.4 0.00035 21.2 0.0 3.1 3 0 0 3 3 3 1 WD domain, G-beta repeat CX9C PF16860.3 MSTRG.298.4_2 - 2.3e-25 88.2 10.9 4.9e-18 64.7 2.4 2.2 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.11 MSTRG.298.4_2 - 0.0016 18.4 11.9 0.098 12.7 2.9 2.6 2 0 0 2 2 2 2 CHCH domain NDUF_B7 PF05676.11 MSTRG.298.4_2 - 0.0019 17.7 0.5 0.0019 17.7 0.5 2.6 1 1 2 3 3 3 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.8 MSTRG.298.4_2 - 0.008 16.1 12.5 0.12 12.3 2.4 3.0 1 1 3 4 4 4 3 Cytochrome c oxidase biogenesis protein Cmc1 like DUF1690 PF07956.9 MSTRG.298.4_2 - 0.078 13.3 0.9 0.11 12.8 0.9 1.2 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) GCK PF07802.9 MSTRG.298.4_2 - 0.4 11.0 9.3 0.79 10.1 0.7 2.3 1 1 1 2 2 2 0 GCK domain COX6B PF02297.15 MSTRG.298.4_2 - 0.83 9.8 10.9 5.9 7.1 1.9 2.4 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb Pet191_N PF10203.7 MSTRG.298.4_2 - 1.4 9.2 16.2 0.6 10.3 9.0 2.7 2 1 1 3 3 3 0 Cytochrome c oxidase assembly protein PET191 UPF0203 PF05254.10 MSTRG.298.4_2 - 1.6 8.9 9.6 5.4 7.2 4.1 3.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) Acetyltransf_13 PF13880.4 MSTRG.15070.3_1 - 7.1e-30 102.7 0.0 1.3e-29 101.9 0.0 1.5 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.4 MSTRG.15070.3_1 - 1e-15 57.1 0.5 1.9e-15 56.2 0.5 1.4 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO TerB_C PF15615.4 MSTRG.15070.3_3 - 2.4 8.3 5.2 0.21 11.8 0.7 1.5 2 0 0 2 2 2 0 TerB-C domain V-set PF07686.15 MSTRG.17166.1_3 - 0.00031 20.7 0.1 0.008 16.2 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin V-set domain C2-set_2 PF08205.10 MSTRG.17166.1_3 - 0.02 14.8 0.0 0.049 13.6 0.0 1.7 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Pkinase PF00069.23 MSTRG.1844.1_2 - 2.1e-29 102.5 0.0 2.7e-29 102.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.1844.1_2 - 1.4e-24 86.7 0.1 1.7e-24 86.4 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 MSTRG.1844.1_2 - 0.0023 17.2 0.1 0.0045 16.2 0.1 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 MSTRG.1844.1_2 - 0.021 14.6 0.0 0.12 12.2 0.0 1.8 1 1 0 2 2 2 0 Phosphotransferase enzyme family Ig_3 PF13927.4 MSTRG.18908.1_1 - 1.6e-60 201.6 3.8 1.3e-13 51.2 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.14 MSTRG.18908.1_1 - 7.3e-54 179.7 0.0 8.2e-12 44.9 0.1 4.3 4 0 0 4 4 4 4 Immunoglobulin I-set domain ig PF00047.23 MSTRG.18908.1_1 - 1.3e-43 146.9 0.4 4.3e-10 39.5 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.18908.1_1 - 7.9e-43 144.6 1.2 5.9e-10 39.2 0.1 4.4 4 0 0 4 4 4 4 Immunoglobulin domain V-set PF07686.15 MSTRG.18908.1_1 - 2.7e-21 75.7 7.9 0.01 15.8 0.1 8.2 5 3 2 7 7 7 7 Immunoglobulin V-set domain C2-set_2 PF08205.10 MSTRG.18908.1_1 - 1.9e-06 27.7 10.2 0.57 10.2 0.0 5.0 6 0 0 6 6 6 3 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 MSTRG.18908.1_1 - 1.2e-05 25.1 0.0 6.6 6.7 0.0 4.4 4 0 0 4 4 4 2 Izumo-like Immunoglobulin domain SCP2 PF02036.15 MSTRG.29412.1_1 - 1.7e-18 66.8 0.0 2.3e-18 66.4 0.0 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.4 MSTRG.29412.1_1 - 0.027 14.6 0.0 0.038 14.1 0.0 1.2 1 0 0 1 1 1 0 Alkyl sulfatase C-terminal RabGAP-TBC PF00566.16 MSTRG.26394.1_3 - 2.1e-50 171.3 0.0 3.5e-50 170.5 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF4805 PF16063.3 MSTRG.26394.1_3 - 0.011 15.1 0.1 0.021 14.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4805) SPX PF03105.17 MSTRG.18539.1_1 - 3.1 7.5 5.0 4 7.2 5.0 1.1 1 0 0 1 1 1 0 SPX domain FERM_C PF09380.8 MSTRG.18539.1_3 - 1.2e-23 83.1 0.1 2.1e-23 82.4 0.1 1.4 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FA PF08736.9 MSTRG.18539.1_3 - 1.5e-16 60.1 0.4 3.4e-16 58.9 0.4 1.7 1 0 0 1 1 1 1 FERM adjacent (FA) FERM_M PF00373.16 MSTRG.18539.1_3 - 3.8e-05 23.9 0.0 6.4e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 FERM central domain Collagen PF01391.16 MSTRG.18539.1_3 - 2.6 7.7 6.9 5.2 6.8 6.9 1.4 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) FHA PF00498.24 MSTRG.19349.1_1 - 0.00029 21.0 0.0 0.00041 20.5 0.0 1.2 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.3 MSTRG.19349.1_1 - 0.0028 17.8 0.0 0.0037 17.4 0.0 1.1 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DIOX_N PF14226.4 MSTRG.22502.1_1 - 2.5e-18 66.8 0.0 4e-18 66.2 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.18 MSTRG.22502.1_1 - 7.1e-14 52.0 0.0 1.4e-13 51.1 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SUIM_assoc PF16619.3 MSTRG.7041.3_2 - 4.1 7.4 14.8 0.063 13.2 5.3 3.0 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DUF4672 PF15716.3 MSTRG.19324.1_3 - 0.0051 16.3 0.5 0.011 15.3 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4672) SBF2 PF12335.6 MSTRG.17388.1_3 - 1.3e-103 345.5 0.1 2.5e-103 344.5 0.1 1.6 1 0 0 1 1 1 1 Myotubularin protein Myotub-related PF06602.12 MSTRG.17388.1_3 - 1.8e-85 286.8 0.1 3e-85 286.1 0.1 1.3 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DENN PF02141.19 MSTRG.17388.1_3 - 6.9e-50 169.5 1.6 9.5e-50 169.0 0.3 2.0 2 0 0 2 2 2 1 DENN (AEX-3) domain uDENN PF03456.16 MSTRG.17388.1_3 - 9.8e-19 67.8 0.1 3e-18 66.3 0.1 1.9 1 0 0 1 1 1 1 uDENN domain PH PF00169.27 MSTRG.17388.1_3 - 1.5e-13 51.1 0.0 4.6e-13 49.5 0.0 1.9 1 0 0 1 1 1 1 PH domain GRAM PF02893.18 MSTRG.17388.1_3 - 1.8e-13 50.2 0.0 2.4e-12 46.6 0.0 2.7 2 0 0 2 2 2 1 GRAM domain dDENN PF03455.17 MSTRG.17388.1_3 - 6.4e-05 22.7 0.0 0.00019 21.2 0.0 1.9 1 0 0 1 1 1 1 dDENN domain PH_8 PF15409.4 MSTRG.17388.1_3 - 7.6e-05 22.8 0.0 0.00018 21.5 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain SPA PF08616.8 MSTRG.17388.1_3 - 0.00063 19.5 0.1 0.0039 17.0 0.0 2.2 2 0 0 2 2 2 1 Stabilization of polarity axis PH_2 PF08458.8 MSTRG.17388.1_3 - 0.018 15.2 0.0 0.041 14.1 0.0 1.6 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PH_11 PF15413.4 MSTRG.17388.1_3 - 0.025 14.9 0.0 0.065 13.5 0.0 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain HicA_toxin PF07927.10 MSTRG.19850.1_1 - 0.062 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 HicA toxin of bacterial toxin-antitoxin, DUF3827 PF12877.5 MSTRG.11617.1_1 - 2.8e-28 98.6 4.0 3.6e-27 94.9 4.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF3827) Kinesin PF00225.21 MSTRG.5864.1_1 - 1.4e-120 402.1 0.4 1.4e-120 402.1 0.4 1.7 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.3 MSTRG.5864.1_1 - 2.1e-27 95.8 0.5 2.1e-27 95.8 0.5 2.2 2 0 0 2 2 2 1 Microtubule binding TRF PF08558.8 MSTRG.5864.1_1 - 0.0077 15.7 5.6 0.48 9.9 0.0 3.3 3 0 0 3 3 3 1 Telomere repeat binding factor (TRF) DUF1974 PF09317.9 MSTRG.5864.1_1 - 0.46 9.9 9.5 0.039 13.4 4.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1974) Glycos_transf_2 PF00535.24 MSTRG.8847.3_2 - 4e-23 81.9 0.0 6.3e-23 81.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.20 MSTRG.8847.3_2 - 9.1e-15 54.9 0.1 2.1e-14 53.7 0.1 1.6 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.4 MSTRG.8847.3_2 - 4.6e-06 26.6 0.0 7e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.12 MSTRG.8847.3_2 - 1.1e-05 24.9 0.0 1.9e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 MSTRG.8847.3_2 - 0.0086 15.4 0.0 0.017 14.4 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 DIM PF08194.10 MSTRG.19293.1_1 - 0.04 14.0 0.1 3.9 7.6 0.0 2.3 2 0 0 2 2 2 0 DIM protein G-alpha PF00503.18 MSTRG.23702.1_3 - 9.7e-110 366.9 8.4 1.3e-109 366.5 8.4 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 MSTRG.23702.1_3 - 3.6e-12 46.0 1.6 2.3e-08 33.6 0.1 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 MSTRG.23702.1_3 - 0.0016 17.7 0.5 0.04 13.1 0.0 2.2 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Roc PF08477.11 MSTRG.23702.1_3 - 0.066 13.3 0.1 4.6 7.4 0.1 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase THF_DHG_CYH_C PF02882.17 MSTRG.23420.1_1 - 1.4e-63 212.9 0.7 2.2e-63 212.2 0.7 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.21 MSTRG.23420.1_1 - 2e-32 111.7 1.0 2e-32 111.7 1.0 1.8 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain COX7a PF02238.13 MSTRG.23420.1_1 - 2.5e-07 30.8 0.0 5.9e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII SRF-TF PF00319.16 MSTRG.16679.1_3 - 1.3e-22 78.9 0.5 1.3e-22 78.9 0.5 2.1 2 0 0 2 2 2 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.6 MSTRG.16679.1_3 - 0.065 13.1 0.0 0.065 13.1 0.0 2.5 3 0 0 3 3 3 0 Holliday junction regulator protein family C-terminal repeat CPSase_L_D2 PF02786.15 MSTRG.1519.6_1 - 3.7e-60 202.9 0.1 5.5e-60 202.3 0.1 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.17 MSTRG.1519.6_1 - 4.4e-36 123.1 0.0 8e-36 122.3 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.20 MSTRG.1519.6_1 - 2e-18 65.9 2.0 2e-18 65.9 2.0 2.3 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.4 MSTRG.1519.6_1 - 1.6e-07 31.0 0.0 0.00021 20.9 0.0 2.5 1 1 1 2 2 2 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.11 MSTRG.1519.6_1 - 0.00021 20.8 0.0 0.00042 19.8 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus HlyD_3 PF13437.4 MSTRG.1519.6_1 - 0.018 15.6 0.1 0.068 13.7 0.1 2.0 1 1 1 2 2 2 0 HlyD family secretion protein RimK PF08443.9 MSTRG.1519.6_1 - 0.04 13.4 0.0 0.067 12.6 0.0 1.4 1 0 0 1 1 1 0 RimK-like ATP-grasp domain ATPgrasp_Ter PF15632.4 MSTRG.1519.6_1 - 0.041 12.4 0.0 0.062 11.9 0.0 1.2 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon HlyD_D23 PF16576.3 MSTRG.1519.6_1 - 0.043 12.9 0.1 0.18 10.9 0.1 1.9 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion PYNP_C PF07831.11 MSTRG.1519.6_1 - 0.045 13.3 1.0 5.4 6.6 0.1 3.1 2 1 1 3 3 3 0 Pyrimidine nucleoside phosphorylase C-terminal domain PASTA PF03793.17 MSTRG.1519.6_1 - 0.14 11.9 0.1 0.52 10.1 0.1 2.0 1 0 0 1 1 1 0 PASTA domain Glyco_transf_54 PF04666.11 MSTRG.22545.2_1 - 8e-92 307.0 0.1 1.3e-91 306.4 0.1 1.3 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region BK_channel_a PF03493.16 MSTRG.18100.1_2 - 0.1 12.7 0.5 0.22 11.6 0.5 1.6 1 0 0 1 1 1 0 Calcium-activated BK potassium channel alpha subunit ALMT PF11744.6 MSTRG.18100.1_2 - 0.52 8.9 6.2 0.66 8.6 6.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF349 PF03993.10 MSTRG.18100.1_2 - 4.8 7.4 10.9 0.89 9.8 6.3 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) DUF106 PF01956.14 MSTRG.18100.1_2 - 4.9 6.7 6.1 5.8 6.5 5.1 1.6 1 1 0 1 1 1 0 Integral membrane protein DUF106 UDPGT PF00201.16 MSTRG.913.1_3 - 1.3e-144 482.6 0.0 1.6e-144 482.3 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 MSTRG.913.1_3 - 0.00041 20.2 0.0 0.00075 19.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain eRF1_2 PF03464.13 MSTRG.913.1_3 - 0.12 12.6 0.0 2.2 8.5 0.0 2.6 2 1 1 3 3 3 0 eRF1 domain 2 RRM_1 PF00076.20 MSTRG.5599.2_2 - 0.057 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRO1 PF03097.16 MSTRG.9967.2_3 - 2.8e-114 381.8 2.9 2.8e-114 381.8 2.9 2.1 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.4 MSTRG.9967.2_3 - 2.2e-89 299.5 10.6 2.2e-89 299.5 10.6 2.2 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV RPT PF13446.4 MSTRG.9967.2_3 - 0.035 13.9 0.0 0.1 12.4 0.0 1.8 1 0 0 1 1 1 0 A repeated domain in UCH-protein DUF4116 PF13475.4 MSTRG.9967.2_3 - 0.057 13.0 0.0 0.17 11.5 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4116) AAT PF03417.14 MSTRG.9967.2_3 - 0.6 9.6 3.2 2.9 7.4 0.1 2.4 2 0 0 2 2 2 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase FlgT_M PF16539.3 MSTRG.9967.2_3 - 0.73 9.8 4.0 2.2 8.2 4.0 1.8 1 0 0 1 1 1 0 Flagellar assembly protein T, middle domain Sec8_exocyst PF04048.12 MSTRG.9967.2_3 - 7.1 6.4 11.2 2.4 7.9 3.0 3.3 3 0 0 3 3 3 0 Sec8 exocyst complex component specific domain STAT_int PF02865.15 MSTRG.2202.2_1 - 4.7e-26 91.5 5.9 4.7e-26 91.5 5.9 2.2 1 1 1 2 2 2 1 STAT protein, protein interaction domain FliD_N PF02465.16 MSTRG.2202.2_1 - 0.18 12.4 0.6 0.38 11.4 0.6 1.5 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus Fib_alpha PF08702.8 MSTRG.2202.2_1 - 1.1 9.4 4.3 0.47 10.5 0.5 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family STAT_bind PF02864.13 MSTRG.2202.2_2 - 6.1e-83 278.4 2.6 9.3e-83 277.8 2.6 1.3 1 0 0 1 1 1 1 STAT protein, DNA binding domain SH2 PF00017.22 MSTRG.2202.2_2 - 4.4e-07 29.7 0.0 9.1e-07 28.7 0.0 1.6 1 0 0 1 1 1 1 SH2 domain DEAD PF00270.27 MSTRG.8311.1_1 - 2.9e-72 242.0 0.0 4.9e-72 241.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.8311.1_1 - 7.7e-26 90.5 0.1 2e-25 89.2 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SPRY PF00622.26 MSTRG.8311.1_1 - 1.1e-23 83.5 1.4 1.3e-23 83.3 0.3 1.7 2 0 0 2 2 2 1 SPRY domain CMS1 PF14617.4 MSTRG.8311.1_1 - 0.00095 18.4 0.1 0.0032 16.7 0.0 1.8 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.13 MSTRG.8311.1_1 - 0.0025 17.7 0.0 0.079 12.8 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SH2 PF00017.22 MSTRG.17276.1_1 - 2.2e-13 49.9 0.0 3.6e-13 49.3 0.0 1.3 1 0 0 1 1 1 1 SH2 domain Pkinase_Tyr PF07714.15 MSTRG.17276.1_3 - 5.2e-97 324.1 0.0 7.6e-97 323.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.17276.1_3 - 1.2e-51 175.5 0.0 1.7e-51 175.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kazal_2 PF07648.13 MSTRG.21984.1_1 - 5.5e-13 48.8 25.0 1.7e-05 24.8 0.6 4.9 4 0 0 4 4 4 3 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 MSTRG.21984.1_1 - 2.8e-06 27.1 19.2 0.001 18.9 1.6 4.6 2 1 1 3 3 3 3 Kazal-type serine protease inhibitor domain Myotoxins PF00819.15 MSTRG.21984.1_1 - 0.49 10.6 8.4 0.69 10.1 1.9 3.3 2 0 0 2 2 2 0 Myotoxin, crotamine Dynamin_M PF01031.18 MSTRG.18919.2_2 - 2.2e-109 364.9 2.2 2.2e-109 364.9 2.2 1.6 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.21 MSTRG.18919.2_2 - 4.6e-55 186.1 0.0 9.3e-55 185.1 0.0 1.6 1 0 0 1 1 1 1 Dynamin family GED PF02212.16 MSTRG.18919.2_2 - 6.7e-26 90.1 2.1 6.7e-26 90.1 2.1 1.9 2 0 0 2 2 2 1 Dynamin GTPase effector domain PH PF00169.27 MSTRG.18919.2_2 - 8.9e-13 48.5 0.5 1.7e-12 47.7 0.5 1.5 1 0 0 1 1 1 1 PH domain MMR_HSR1 PF01926.21 MSTRG.18919.2_2 - 0.0002 21.3 0.1 0.0011 18.9 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase PH_11 PF15413.4 MSTRG.18919.2_2 - 0.27 11.5 1.3 1.4 9.2 1.3 2.2 1 1 0 1 1 1 0 Pleckstrin homology domain NAD_binding_6 PF08030.10 MSTRG.25085.1_3 - 1.1e-31 110.0 0.0 1.4e-31 109.6 0.0 1.1 1 0 0 1 1 1 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.19 MSTRG.25085.1_3 - 0.00089 19.7 0.0 0.0095 16.4 0.0 2.2 2 1 0 2 2 2 1 Oxidoreductase NAD-binding domain RasGEF PF00617.17 MSTRG.7229.1_3 - 7e-48 162.9 0.0 1.2e-47 162.2 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain PDZ PF00595.22 MSTRG.7229.1_3 - 9.1e-13 48.2 0.0 2e-12 47.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) RasGEF_N PF00618.18 MSTRG.7229.1_3 - 3e-12 46.6 0.2 3.7e-11 43.1 0.2 2.4 1 1 0 1 1 1 1 RasGEF N-terminal motif RA PF00788.21 MSTRG.7229.1_3 - 1.6e-11 44.5 0.0 3.4e-11 43.5 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain cNMP_binding PF00027.27 MSTRG.7229.1_3 - 1.3e-08 34.6 0.0 2.7e-05 23.9 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain PDZ_2 PF13180.4 MSTRG.7229.1_3 - 0.00013 22.0 0.0 0.00046 20.3 0.0 1.9 1 0 0 1 1 1 1 PDZ domain Merozoite_SPAM PF07133.9 MSTRG.29249.1_2 - 0.026 14.4 35.4 0.035 14.0 35.4 1.3 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Peptidase_S64 PF08192.9 MSTRG.29249.1_2 - 0.6 8.4 15.0 0.68 8.2 15.0 1.1 1 0 0 1 1 1 0 Peptidase family S64 MIP-T3 PF10243.7 MSTRG.29249.1_2 - 2.5 6.6 26.3 2.7 6.5 26.3 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Tim54 PF11711.6 MSTRG.29249.1_2 - 3 6.4 11.6 3.4 6.2 11.6 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Plasmodium_Vir PF05795.9 MSTRG.29249.1_2 - 3.6 6.8 12.0 4 6.6 12.0 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Nop14 PF04147.10 MSTRG.29249.1_2 - 4 5.4 36.1 4.5 5.2 36.1 1.1 1 0 0 1 1 1 0 Nop14-like family HSP90 PF00183.16 MSTRG.29249.1_2 - 8.9 4.9 16.5 10 4.7 16.5 1.3 1 0 0 1 1 1 0 Hsp90 protein Rrn6 PF10214.7 MSTRG.29249.1_3 - 1.1 7.5 19.1 1.4 7.1 19.1 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor MCU PF04678.11 MSTRG.27645.2_3 - 5.2e-63 212.2 1.5 7.3e-63 211.8 1.5 1.2 1 0 0 1 1 1 1 Mitochondrial calcium uniporter zf-CDGSH PF09360.8 MSTRG.13168.2_2 - 5.6e-16 58.4 9.0 3.2e-09 36.7 0.9 3.0 3 0 0 3 3 3 2 Iron-binding zinc finger CDGSH type I-set PF07679.14 MSTRG.24782.1_2 - 3e-25 88.0 0.6 1.6e-08 34.3 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.24782.1_2 - 1.2e-13 51.3 0.3 0.0012 19.3 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.24782.1_2 - 1.8e-07 31.2 0.1 0.0073 16.5 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.23 MSTRG.24782.1_2 - 1.7e-05 24.8 1.5 0.63 10.1 0.1 3.6 3 2 0 3 3 3 2 Immunoglobulin domain Izumo-Ig PF16706.3 MSTRG.24782.1_2 - 3.4e-05 23.7 0.8 0.013 15.4 0.1 3.2 4 0 0 4 4 4 2 Izumo-like Immunoglobulin domain V-set PF07686.15 MSTRG.24782.1_2 - 0.0012 18.9 0.1 2.3 8.3 0.0 3.5 4 0 0 4 4 4 2 Immunoglobulin V-set domain SoxZ PF08770.9 MSTRG.24782.1_2 - 0.15 11.7 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 Sulphur oxidation protein SoxZ RhoGAP PF00620.25 MSTRG.21327.1_2 - 5.3e-48 162.6 0.0 9.4e-48 161.8 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain SH3-WW_linker PF16618.3 MSTRG.21327.1_2 - 1e-45 156.5 26.6 1e-45 156.5 26.6 2.9 2 1 0 2 2 2 1 Linker region between SH3 and WW domains on ARHGAP12 SH3_9 PF14604.4 MSTRG.21327.1_2 - 3.6e-11 42.6 0.1 7.2e-11 41.6 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.24 MSTRG.21327.1_2 - 1.6e-09 37.4 6.8 1.8e-05 24.4 1.1 2.9 2 0 0 2 2 2 2 WW domain PH PF00169.27 MSTRG.21327.1_2 - 6.4e-09 36.1 0.1 2e-08 34.6 0.1 1.9 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.26 MSTRG.21327.1_2 - 1.4e-05 24.4 0.2 3.4e-05 23.2 0.2 1.7 1 0 0 1 1 1 1 SH3 domain PH_9 PF15410.4 MSTRG.21327.1_2 - 0.0027 18.0 0.1 0.0099 16.1 0.1 1.9 1 1 0 1 1 1 1 Pleckstrin homology domain PPDFL PF15060.4 MSTRG.21327.1_2 - 0.016 15.6 0.0 0.045 14.2 0.0 1.7 1 0 0 1 1 1 0 Differentiation and proliferation regulator Myosin_head PF00063.19 MSTRG.1426.4_2 - 1.6e-266 885.8 3.9 2.1e-266 885.4 3.9 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.11 MSTRG.1426.4_2 - 1.9e-39 135.1 6.1 3.1e-39 134.4 0.5 2.7 3 0 0 3 3 3 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.25 MSTRG.1426.4_2 - 1.3e-06 27.6 22.7 0.0021 17.5 0.1 5.2 5 0 0 5 5 5 3 IQ calmodulin-binding motif AAA_16 PF13191.4 MSTRG.1426.4_2 - 0.0038 17.5 0.1 0.016 15.5 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.4 MSTRG.1426.4_2 - 0.023 14.8 0.0 0.1 12.7 0.0 2.1 1 0 0 1 1 1 0 AAA domain Evr1_Alr PF04777.11 MSTRG.1426.4_2 - 0.038 14.4 0.3 1.5 9.2 0.1 3.1 2 1 0 2 2 2 0 Erv1 / Alr family Yqai PF09466.8 MSTRG.1426.4_2 - 0.092 12.9 0.2 0.31 11.3 0.2 1.9 1 1 0 1 1 1 0 Hypothetical protein Yqai Hpr_kinase_C PF07475.10 MSTRG.1426.4_2 - 0.22 10.9 0.8 2.9 7.2 0.0 2.4 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain G_path_suppress PF15991.3 MSTRG.1046.1_1 - 2e-75 254.4 18.3 2e-75 254.4 18.3 1.3 1 1 0 1 1 1 1 G-protein pathway suppressor PRCC PF10253.7 MSTRG.1046.1_1 - 0.076 13.7 8.3 0.18 12.4 8.3 1.7 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting MAT1 PF06391.11 MSTRG.1046.1_1 - 0.54 9.9 18.3 0.81 9.3 18.3 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Peptidase_S46 PF10459.7 MSTRG.1046.1_1 - 0.8 8.1 8.3 1.1 7.7 8.3 1.1 1 0 0 1 1 1 0 Peptidase S46 MIF4G_like_2 PF09090.9 MSTRG.1046.1_1 - 1.4 8.2 9.8 2.1 7.6 9.8 1.2 1 0 0 1 1 1 0 MIF4G like Exonuc_VII_L PF02601.13 MSTRG.1046.1_1 - 5.1 6.4 9.0 7.2 5.9 9.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2252 PF10009.7 MSTRG.1046.1_1 - 8.2 5.2 8.7 12 4.7 8.7 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) Tetraspannin PF00335.18 MSTRG.21517.1_3 - 1.4e-42 145.7 16.1 1.4e-42 145.7 16.1 2.9 3 0 0 3 3 3 1 Tetraspanin family DUF4044 PF13253.4 MSTRG.21517.1_3 - 1.6 8.1 6.8 4 6.9 6.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4044) DUF755 PF05501.9 MSTRG.19223.6_2 - 0.022 14.9 9.2 0.042 14.0 9.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Abi_HHR PF07815.12 MSTRG.19223.6_3 - 3.2e-34 116.8 0.5 6.3e-34 115.8 0.5 1.4 1 0 0 1 1 1 1 Abl-interactor HHR SH3_9 PF14604.4 MSTRG.19223.6_3 - 1.5e-15 56.6 0.2 3.3e-15 55.5 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.19223.6_3 - 5.3e-15 54.6 0.1 9.3e-15 53.8 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.19223.6_3 - 3.1e-10 39.5 0.1 6.2e-10 38.5 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SNF2_N PF00176.21 MSTRG.18166.1_1 - 7.1e-68 228.7 2.0 1.3e-67 227.9 2.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.29 MSTRG.18166.1_1 - 6.9e-19 68.1 0.1 1.7e-18 66.9 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HSA PF07529.11 MSTRG.18166.1_1 - 7.7e-18 64.5 8.4 7.7e-18 64.5 8.4 2.9 2 1 1 3 3 3 1 HSA AT_hook PF02178.17 MSTRG.18166.1_1 - 0.028 14.1 16.5 0.63 10.0 4.1 3.9 2 0 0 2 2 2 0 AT hook motif DUF2615 PF11027.6 MSTRG.18166.1_1 - 0.065 13.2 0.3 0.33 11.0 0.3 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) DUF4736 PF15883.3 MSTRG.18166.1_1 - 2.6 7.6 4.4 6.5 6.3 4.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4736) DBINO PF13892.4 MSTRG.18166.1_1 - 4.2 7.6 18.6 0.015 15.5 7.9 2.5 2 0 0 2 2 2 0 DNA-binding domain Lig_chan PF00060.24 MSTRG.20483.1_3 - 3.3e-37 127.5 0.1 5.6e-37 126.7 0.1 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 MSTRG.20483.1_3 - 6.7e-37 126.1 0.1 1e-36 125.5 0.1 1.3 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 MSTRG.20483.1_3 - 3.7e-21 75.4 0.0 5.1e-21 75.0 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 FtsH_ext PF06480.13 MSTRG.20483.1_3 - 0.033 14.4 0.1 0.033 14.4 0.1 1.8 2 0 0 2 2 2 0 FtsH Extracellular UbiA PF01040.16 MSTRG.6291.1_3 - 1.6e-37 129.0 12.8 2.2e-37 128.6 12.8 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family LRRNT PF01462.16 MSTRG.24753.1_3 - 0.00031 20.2 1.2 0.00031 20.2 1.2 2.8 3 0 0 3 3 3 2 Leucine rich repeat N-terminal domain AKAP7_NLS PF10469.7 MSTRG.1514.2_2 - 8.7e-55 185.7 0.0 1.2e-54 185.3 0.0 1.2 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain KH_1 PF00013.27 MSTRG.1514.2_2 - 4.3e-11 42.4 0.7 7.2e-11 41.6 0.7 1.4 1 0 0 1 1 1 1 KH domain PBC PF03792.11 MSTRG.12727.1_3 - 5.7e-40 137.0 0.1 7.8e-40 136.5 0.1 1.2 1 0 0 1 1 1 1 PBC domain KIND PF16474.3 MSTRG.23268.2_3 - 4.9e-77 258.1 0.0 8.5e-77 257.3 0.0 1.4 1 0 0 1 1 1 1 Kinase non-catalytic C-lobe domain FYVE PF01363.19 MSTRG.23268.2_3 - 7.9e-05 22.6 3.0 0.00017 21.5 0.6 2.4 2 0 0 2 2 2 1 FYVE zinc finger C1_2 PF03107.14 MSTRG.23268.2_3 - 1.7 8.9 6.1 4.7 7.5 6.1 1.7 1 0 0 1 1 1 0 C1 domain fn3 PF00041.19 MSTRG.17754.2_3 - 3.3e-147 479.1 51.7 1.6e-14 53.9 0.5 12.4 12 0 0 12 12 12 12 Fibronectin type III domain VWA PF00092.26 MSTRG.17754.2_3 - 3e-105 349.8 3.0 1.6e-52 178.1 1.8 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain Collagen PF01391.16 MSTRG.17754.2_3 - 1.9e-34 117.1 169.6 2.2e-08 33.6 29.8 5.4 2 2 3 5 5 5 5 Collagen triple helix repeat (20 copies) VWA_2 PF13519.4 MSTRG.17754.2_3 - 2e-28 99.1 0.0 2e-15 57.3 0.0 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain Interfer-bind PF09294.8 MSTRG.17754.2_3 - 9.3e-19 67.5 0.0 1.9 8.7 0.0 11.1 12 0 0 12 12 12 3 Interferon-alpha/beta receptor, fibronectin type III Pur_ac_phosph_N PF16656.3 MSTRG.17754.2_3 - 1.3e-15 57.5 42.2 0.11 13.0 0.2 13.1 12 2 0 12 12 11 6 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.7 MSTRG.17754.2_3 - 1.3e-13 51.0 1.7 1 9.8 0.0 9.7 11 0 0 11 11 11 2 Uncharacterised conserved protein (DUF2369) DUF4998 PF16389.3 MSTRG.17754.2_3 - 6.7e-09 35.5 0.2 6.8 6.1 0.0 8.2 11 0 0 11 11 11 2 Domain of unknown function DUF4992 PF16383.3 MSTRG.17754.2_3 - 0.025 14.0 0.0 0.46 9.9 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function fn3_2 PF16893.3 MSTRG.17754.2_3 - 0.07 13.1 0.1 91 3.2 0.0 4.5 5 0 0 5 5 5 0 Fibronectin type III domain SWM_repeat PF13753.4 MSTRG.17754.2_3 - 0.082 12.9 0.0 18 5.4 0.1 2.9 2 0 0 2 2 2 0 Putative flagellar system-associated repeat GCS PF03074.14 MSTRG.7663.1_2 - 5e-179 595.2 0.0 6.2e-179 594.9 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase GCS2 PF04107.11 MSTRG.7663.1_2 - 0.012 14.9 0.0 0.02 14.1 0.0 1.3 1 0 0 1 1 1 0 Glutamate-cysteine ligase family 2(GCS2) IN_DBD_C PF00552.19 MSTRG.22641.6_1 - 0.049 12.8 0.2 0.14 11.4 0.2 1.7 1 0 0 1 1 1 0 Integrase DNA binding domain Wtap PF17098.3 MSTRG.22641.6_2 - 7.6e-23 81.0 3.2 7.6e-23 81.0 3.2 1.9 1 1 1 2 2 2 1 WTAP/Mum2p family DUF2000 PF09391.8 MSTRG.22641.6_2 - 0.066 13.0 0.6 0.11 12.3 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2000) HOOK PF05622.10 MSTRG.23753.1_2 - 4.4e-106 355.6 34.6 5.1e-106 355.3 34.6 1.0 1 0 0 1 1 1 1 HOOK protein Spc7 PF08317.9 MSTRG.23753.1_2 - 0.00016 20.5 31.7 0.00073 18.4 14.6 2.2 2 0 0 2 2 2 2 Spc7 kinetochore protein GAS PF13851.4 MSTRG.23753.1_2 - 0.14 11.4 34.9 0.041 13.1 8.6 2.6 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Fib_alpha PF08702.8 MSTRG.23753.1_2 - 0.19 11.8 20.5 0.018 15.1 6.9 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family NPV_P10 PF05531.10 MSTRG.23753.1_2 - 0.78 10.1 16.8 0.24 11.8 7.1 3.3 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein HR1 PF02185.14 MSTRG.23753.1_2 - 1.4 9.0 23.5 1.3 9.1 10.5 3.5 3 1 0 3 3 3 0 Hr1 repeat DUF4795 PF16043.3 MSTRG.23753.1_2 - 2.2 7.7 22.4 3.8 6.9 22.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) ATG16 PF08614.9 MSTRG.23753.1_2 - 3.8 7.5 36.0 5.2 7.1 22.6 3.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) SAM_1 PF00536.28 MSTRG.12304.1_2 - 6e-42 141.8 4.5 1.4e-18 66.9 0.1 3.7 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 MSTRG.12304.1_2 - 1.4e-38 130.7 3.4 7.5e-14 51.5 0.0 4.3 4 0 0 4 4 4 3 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 MSTRG.12304.1_2 - 0.015 15.1 1.5 0.59 10.0 0.2 2.7 2 0 0 2 2 2 0 Sterile alpha motif (SAM)/Pointed domain Reo_sigmaC PF04582.10 MSTRG.12304.1_2 - 0.022 14.0 9.7 0.25 10.6 8.9 2.3 1 1 0 1 1 1 0 Reovirus sigma C capsid protein FxsA PF04186.11 MSTRG.12304.1_2 - 0.044 13.8 0.0 0.082 12.9 0.0 1.4 1 0 0 1 1 1 0 FxsA cytoplasmic membrane protein DUF5082 PF16888.3 MSTRG.12304.1_2 - 0.053 13.7 14.1 0.062 13.5 8.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) ADIP PF11559.6 MSTRG.12304.1_2 - 0.13 12.2 29.4 0.15 12.0 10.4 3.3 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding 4HB_MCP_1 PF12729.5 MSTRG.12304.1_2 - 0.25 10.7 9.5 0.4 10.1 8.6 1.7 1 1 0 1 1 1 0 Four helix bundle sensory module for signal transduction DUF3450 PF11932.6 MSTRG.12304.1_2 - 0.51 9.5 26.5 1.8 7.7 13.5 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) WHEP-TRS PF00458.18 MSTRG.12304.1_2 - 0.63 10.1 7.0 0.32 11.1 0.1 3.1 3 0 0 3 3 3 0 WHEP-TRS domain DUF16 PF01519.14 MSTRG.12304.1_2 - 0.77 10.1 20.0 0.02 15.2 4.3 3.2 1 1 0 2 2 2 0 Protein of unknown function DUF16 DUF1640 PF07798.9 MSTRG.12304.1_2 - 1.4 8.8 20.3 0.32 10.9 15.2 2.5 1 1 1 3 3 3 0 Protein of unknown function (DUF1640) Pox_A_type_inc PF04508.10 MSTRG.12304.1_2 - 5.5 6.9 15.0 1.7 8.5 0.2 4.5 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat LRRFIP PF09738.7 MSTRG.12304.1_2 - 9.4 5.5 34.7 16 4.8 0.3 2.8 1 1 1 2 2 2 0 LRRFIP family VHS PF00790.17 MSTRG.18983.1_1 - 7.3e-43 145.7 0.0 1.7e-42 144.5 0.0 1.7 1 0 0 1 1 1 1 VHS domain GAT PF03127.12 MSTRG.18983.1_1 - 7e-22 77.4 1.6 1.5e-21 76.3 1.6 1.6 1 0 0 1 1 1 1 GAT domain RPN7 PF10602.7 MSTRG.13700.1_1 - 1.6e-57 193.9 1.2 2.4e-57 193.3 1.2 1.3 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.25 MSTRG.13700.1_1 - 7.2e-18 64.9 0.1 2.5e-17 63.2 0.1 1.9 2 0 0 2 2 2 1 PCI domain DUF2458 PF10454.7 MSTRG.13700.1_1 - 0.031 13.8 0.1 0.058 12.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) SelP_N PF04592.12 MSTRG.13700.1_3 - 1 8.5 12.5 1.6 7.9 12.5 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region CUE PF02845.14 MSTRG.26242.1_2 - 0.0061 16.1 0.0 0.013 15.0 0.0 1.6 1 0 0 1 1 1 1 CUE domain HOIP-UBA PF16678.3 MSTRG.26242.1_2 - 0.041 13.8 0.0 0.08 12.8 0.0 1.4 1 0 0 1 1 1 0 UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase Bax1-I PF01027.18 MSTRG.14114.2_1 - 0.00027 20.7 5.7 0.00027 20.7 5.7 2.0 2 0 0 2 2 2 1 Inhibitor of apoptosis-promoting Bax1 PRT_C PF08372.8 MSTRG.14114.2_1 - 0.034 13.8 0.6 0.053 13.1 0.6 1.3 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal CMV_US PF08001.9 MSTRG.14114.2_1 - 0.14 11.3 0.9 0.18 10.9 0.9 1.1 1 0 0 1 1 1 0 CMV US Vma12 PF11712.6 MSTRG.14114.2_1 - 0.95 9.4 3.0 1.6 8.7 0.7 2.0 1 1 1 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase PTB PF08416.11 MSTRG.25013.2_2 - 3.5e-45 153.2 0.6 5.9e-45 152.5 0.6 1.4 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID PF00640.21 MSTRG.25013.2_2 - 2.4e-06 27.5 0.4 2.3e-05 24.3 0.0 2.1 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) AAA PF00004.27 MSTRG.24731.3_2 - 1.1e-48 164.8 0.0 1.6e-40 138.5 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Bromodomain PF00439.23 MSTRG.24731.3_2 - 9.4e-16 57.5 0.1 2.5e-15 56.2 0.1 1.7 1 0 0 1 1 1 1 Bromodomain IstB_IS21 PF01695.15 MSTRG.24731.3_2 - 1.8e-05 24.5 0.0 0.00021 21.0 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_16 PF13191.4 MSTRG.24731.3_2 - 3e-05 24.3 0.0 0.0014 18.9 0.0 3.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_2 PF07724.12 MSTRG.24731.3_2 - 0.00019 21.4 0.0 0.00057 19.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.4 MSTRG.24731.3_2 - 0.00076 19.6 0.4 0.092 12.9 0.1 3.8 3 1 0 3 3 3 1 AAA domain AAA_18 PF13238.4 MSTRG.24731.3_2 - 0.0062 16.9 2.7 0.054 13.9 0.0 3.3 3 0 0 3 3 3 1 AAA domain ResIII PF04851.13 MSTRG.24731.3_2 - 0.013 15.3 0.0 0.68 9.8 0.0 2.5 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_5 PF07728.12 MSTRG.24731.3_2 - 0.013 15.3 0.0 0.17 11.8 0.0 2.8 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.19 MSTRG.24731.3_2 - 0.019 14.2 0.0 0.48 9.6 0.0 2.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.20 MSTRG.24731.3_2 - 0.028 14.7 0.0 0.1 12.8 0.0 2.0 2 0 0 2 2 2 0 RNA helicase AAA_33 PF13671.4 MSTRG.24731.3_2 - 0.04 13.9 0.3 0.98 9.4 0.0 2.8 3 0 0 3 3 2 0 AAA domain TIP49 PF06068.11 MSTRG.24731.3_2 - 0.043 12.6 0.0 0.52 9.1 0.0 2.1 2 0 0 2 2 2 0 TIP49 C-terminus DUF2075 PF09848.7 MSTRG.24731.3_2 - 0.044 12.9 0.0 0.08 12.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TniB PF05621.9 MSTRG.24731.3_2 - 0.049 12.7 0.0 4.9 6.1 0.0 3.1 3 0 0 3 3 3 0 Bacterial TniB protein RuvB_N PF05496.10 MSTRG.24731.3_2 - 0.065 12.4 0.0 0.15 11.2 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_11 PF13086.4 MSTRG.24731.3_2 - 0.97 9.0 0.0 0.97 9.0 0.0 3.9 4 0 0 4 4 4 0 AAA domain SH2 PF00017.22 MSTRG.16195.1_3 - 4.4e-16 58.6 0.0 8.2e-16 57.7 0.0 1.4 1 0 0 1 1 1 1 SH2 domain RasGEF PF00617.17 MSTRG.16195.1_3 - 1.2e-08 35.2 0.0 3.3e-08 33.8 0.0 1.5 1 1 1 2 2 2 1 RasGEF domain CUB PF00431.18 MSTRG.27497.1_3 - 5.4e-80 264.8 0.0 1.1e-40 138.3 0.0 3.1 3 0 0 3 3 3 3 CUB domain FXa_inhibition PF14670.4 MSTRG.27497.1_3 - 2.5e-10 40.3 7.9 6.4e-10 39.0 7.9 1.8 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site EGF_CA PF07645.13 MSTRG.27497.1_3 - 4.9e-08 32.9 7.6 1.3e-07 31.6 7.6 1.7 1 0 0 1 1 1 1 Calcium-binding EGF domain cEGF PF12662.5 MSTRG.27497.1_3 - 3.8e-06 26.6 2.3 6.5e-06 25.8 0.6 2.4 2 0 0 2 2 2 1 Complement Clr-like EGF-like hEGF PF12661.5 MSTRG.27497.1_3 - 0.001 19.5 5.1 0.0039 17.7 5.1 2.1 1 0 0 1 1 1 1 Human growth factor-like EGF EGF PF00008.25 MSTRG.27497.1_3 - 0.0025 17.9 5.4 0.0057 16.8 5.4 1.6 1 0 0 1 1 1 1 EGF-like domain EGF_3 PF12947.5 MSTRG.27497.1_3 - 0.0035 17.4 4.1 0.0079 16.2 4.1 1.7 1 0 0 1 1 1 1 EGF domain CUB_2 PF02408.18 MSTRG.27497.1_3 - 0.027 14.1 0.1 1 9.0 0.0 2.3 2 0 0 2 2 2 0 CUB-like domain Vinculin PF01044.17 MSTRG.7331.1_1 - 0 1012.8 36.8 6e-211 703.2 22.9 2.0 1 1 1 2 2 2 2 Vinculin family IBR PF01485.19 MSTRG.24611.3_2 - 2.1e-15 56.5 20.2 8.3e-11 41.8 4.1 4.9 4 0 0 4 4 4 2 IBR domain, a half RING-finger domain AP_endonuc_2 PF01261.22 MSTRG.24611.3_2 - 2.1e-05 23.9 0.0 0.00051 19.4 0.0 2.0 1 1 1 2 2 2 1 Xylose isomerase-like TIM barrel Chromo PF00385.22 MSTRG.2316.1_2 - 1.1e-08 34.7 3.9 7.5e-08 32.0 3.9 2.0 1 1 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain TruB_N PF01509.16 MSTRG.24668.1_2 - 0.054 13.7 0.0 0.084 13.1 0.0 1.3 1 0 0 1 1 1 0 TruB family pseudouridylate synthase (N terminal domain) Pro_isomerase PF00160.19 MSTRG.24668.1_3 - 6.4e-45 153.1 0.8 9.5e-45 152.6 0.8 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TmoB PF06234.10 MSTRG.17186.2_2 - 0.073 13.0 1.0 0.77 9.8 0.1 2.3 2 0 0 2 2 2 0 Toluene-4-monooxygenase system protein B (TmoB) LRRNT PF01462.16 MSTRG.17186.2_3 - 0.13 11.8 0.2 0.3 10.7 0.1 1.7 1 1 0 1 1 1 0 Leucine rich repeat N-terminal domain PAS_11 PF14598.4 MSTRG.23863.3_2 - 9.6e-21 73.9 0.0 9.6e-21 73.9 0.0 2.9 3 0 0 3 3 3 1 PAS domain PAS_3 PF08447.10 MSTRG.23863.3_2 - 1.4e-16 60.4 0.2 3.3e-15 56.0 0.1 2.3 2 0 0 2 2 2 1 PAS fold HLH PF00010.24 MSTRG.23863.3_2 - 7.4e-11 41.7 0.6 1.6e-10 40.6 0.6 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS PF00989.23 MSTRG.23863.3_2 - 3.6e-09 36.5 1.5 4.5e-06 26.5 0.0 3.5 3 0 0 3 3 3 1 PAS fold PAS_9 PF13426.5 MSTRG.23863.3_2 - 0.0015 18.7 0.2 0.0087 16.2 0.0 2.4 3 0 0 3 3 3 1 PAS domain Dicty_REP PF05086.10 MSTRG.23863.3_2 - 1.8 6.3 14.3 2.7 5.7 14.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein IncA PF04156.12 MSTRG.23863.3_2 - 2 8.1 24.4 4.6 6.8 24.4 1.6 1 0 0 1 1 1 0 IncA protein Hamartin PF04388.10 MSTRG.23863.3_2 - 3.1 6.2 28.9 5.5 5.4 28.9 1.4 1 0 0 1 1 1 0 Hamartin protein PDZ PF00595.22 MSTRG.11882.2_2 - 2.4e-12 46.9 0.6 4.6e-12 46.0 0.6 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.11882.2_2 - 0.00019 21.5 0.3 0.00034 20.7 0.3 1.4 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.4 MSTRG.11882.2_2 - 0.024 14.5 0.1 0.051 13.5 0.1 1.5 2 0 0 2 2 2 0 Tricorn protease PDZ domain LEM PF03020.13 MSTRG.9348.1_2 - 1e-15 56.8 0.1 2.4e-15 55.6 0.1 1.7 1 0 0 1 1 1 1 LEM domain YL1 PF05764.11 MSTRG.9348.1_2 - 1.3 9.0 7.9 1.9 8.4 7.9 1.2 1 0 0 1 1 1 0 YL1 nuclear protein TAF1_subA PF14929.4 MSTRG.25599.1_3 - 9.8e-101 337.7 17.9 1.3e-100 337.3 17.9 1.1 1 0 0 1 1 1 1 TAF RNA Polymerase I subunit A ABC_tran PF00005.25 MSTRG.20771.1_1 - 7.2e-12 45.9 0.0 1.1e-11 45.3 0.0 1.2 1 0 0 1 1 1 1 ABC transporter SbcCD_C PF13558.4 MSTRG.20771.1_1 - 0.021 14.9 0.9 0.36 11.0 0.9 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit SMC_N PF02463.17 MSTRG.20771.1_1 - 0.088 12.1 0.0 0.088 12.1 0.0 1.1 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain ABC_tran PF00005.25 MSTRG.20771.1_3 - 1.6e-21 77.1 0.0 2.3e-21 76.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter Zeta_toxin PF06414.10 MSTRG.20771.1_3 - 2.5e-05 23.5 0.0 3.4e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin DUF258 PF03193.14 MSTRG.20771.1_3 - 0.00081 19.2 0.0 0.0012 18.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_16 PF13191.4 MSTRG.20771.1_3 - 0.00087 19.6 0.0 0.0012 19.2 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain PRK PF00485.16 MSTRG.20771.1_3 - 0.0011 18.6 0.0 0.0018 17.9 0.0 1.4 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family G-alpha PF00503.18 MSTRG.20771.1_3 - 0.0012 17.9 0.0 0.0015 17.7 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit AAA_22 PF13401.4 MSTRG.20771.1_3 - 0.0031 17.7 0.0 0.004 17.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.13 MSTRG.20771.1_3 - 0.0031 16.4 0.0 0.0043 15.9 0.0 1.1 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_29 PF13555.4 MSTRG.20771.1_3 - 0.008 15.7 0.1 0.015 14.9 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.4 MSTRG.20771.1_3 - 0.012 15.2 0.0 0.014 14.9 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.4 MSTRG.20771.1_3 - 0.024 14.7 0.1 0.17 12.0 0.1 2.0 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.11 MSTRG.20771.1_3 - 0.041 12.9 0.0 0.056 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_24 PF13479.4 MSTRG.20771.1_3 - 0.044 13.4 0.0 0.052 13.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.23 MSTRG.20771.1_3 - 0.05 13.1 0.3 0.13 11.8 0.1 1.6 1 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_18 PF13238.4 MSTRG.20771.1_3 - 0.056 13.8 0.0 0.092 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.20 MSTRG.20771.1_3 - 0.08 12.4 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_30 PF13604.4 MSTRG.20771.1_3 - 0.098 12.2 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain Thyroglobulin_1 PF00086.16 MSTRG.6988.2_1 - 2.4e-17 62.2 1.3 5.5e-17 61.1 1.3 1.7 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat IGFBP PF00219.16 MSTRG.6988.2_1 - 0.0015 19.0 6.5 0.0015 19.0 6.5 2.6 2 0 0 2 2 2 1 Insulin-like growth factor binding protein zf-H2C2_2 PF13465.4 MSTRG.18593.1_1 - 3.3e-31 106.2 34.5 2e-05 24.7 0.5 7.9 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.18593.1_1 - 9.9e-21 72.8 36.6 0.0032 17.7 0.1 7.1 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.18593.1_1 - 5.8e-19 67.0 35.7 0.0065 17.1 0.7 7.4 6 0 0 6 6 6 6 C2H2-type zinc finger HTH_Tnp_Tc5 PF03221.14 MSTRG.18593.1_1 - 1.1e-12 47.7 0.0 2e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain zf-C2H2_6 PF13912.4 MSTRG.18593.1_1 - 1.1e-10 41.0 29.5 0.022 14.5 0.8 6.5 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.18593.1_1 - 3.5e-07 30.2 8.6 0.83 9.9 0.2 5.8 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 MSTRG.18593.1_1 - 5.9e-07 29.5 26.2 0.00013 22.0 3.1 4.3 2 1 4 6 6 5 3 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.5 MSTRG.18593.1_1 - 4.7e-06 26.7 26.5 1.5 9.2 0.0 6.8 6 0 0 6 6 6 4 Zinc-finger of C2H2 type CENP-B_N PF04218.11 MSTRG.18593.1_1 - 1.6e-05 24.3 2.6 1.6e-05 24.3 2.6 2.2 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain Ta0938 PF11494.6 MSTRG.18593.1_1 - 0.00065 19.8 1.8 3 8.0 0.6 3.7 1 1 3 4 4 4 1 Ta0938 zf-C2HC_2 PF13913.4 MSTRG.18593.1_1 - 0.031 14.1 0.2 0.031 14.1 0.2 4.6 7 0 0 7 7 7 0 zinc-finger of a C2HC-type HTH_Tnp_IS630 PF01710.14 MSTRG.18593.1_1 - 0.081 12.8 0.1 0.21 11.5 0.1 1.6 1 0 0 1 1 1 0 Transposase HTH_23 PF13384.4 MSTRG.18593.1_1 - 0.12 12.1 0.2 0.45 10.2 0.2 2.0 1 0 0 1 1 1 0 Homeodomain-like domain zf-C2H2_9 PF16293.3 MSTRG.18593.1_1 - 0.14 11.9 9.4 2.6 7.8 0.1 4.5 3 2 2 5 5 5 0 C2H2 type zinc-finger (1 copy) DUF2225 PF09986.7 MSTRG.18593.1_1 - 0.47 10.0 8.2 0.55 9.8 0.4 3.3 2 1 2 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-C2H2_2 PF12756.5 MSTRG.18593.1_1 - 1.4 9.2 22.6 37 4.6 0.4 5.3 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_15 PF17032.3 MSTRG.18593.1_1 - 3.2 8.5 21.8 1.1 9.9 1.7 4.7 2 1 3 5 5 5 0 zinc-ribbon family Zf_RING PF16744.3 MSTRG.18593.1_1 - 7.2 6.7 15.7 15 5.6 4.3 4.7 1 1 4 5 5 5 0 KIAA1045 RING finger WWE PF02825.18 MSTRG.11919.1_3 - 1.3e-35 121.6 0.6 6.8e-18 64.9 0.0 2.4 2 0 0 2 2 2 2 WWE domain zf-C3HC4 PF00097.23 MSTRG.11919.1_3 - 1.9e-07 30.7 0.3 5.7e-07 29.2 0.3 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.11919.1_3 - 8.3e-05 22.4 1.3 0.00018 21.3 0.2 2.3 2 0 0 2 2 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 MSTRG.11919.1_3 - 0.00013 22.0 1.8 0.0011 19.0 1.8 2.6 1 1 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.5 MSTRG.11919.1_3 - 0.00069 19.7 0.3 0.0018 18.4 0.3 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.3 MSTRG.11919.1_3 - 0.00077 19.0 1.0 0.07 12.7 0.0 2.7 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_5 PF14634.4 MSTRG.11919.1_3 - 0.0037 17.0 0.7 0.0037 17.0 0.7 2.4 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_2 PF13923.4 MSTRG.11919.1_3 - 0.063 13.0 7.8 0.14 11.9 0.5 3.0 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 MSTRG.11919.1_3 - 0.083 12.8 0.2 0.23 11.4 0.2 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-UDP PF14569.4 MSTRG.11919.1_3 - 0.09 12.8 0.3 0.31 11.1 0.3 1.9 1 0 0 1 1 1 0 Zinc-binding RING-finger PHD PF00628.27 MSTRG.11919.1_3 - 0.14 12.0 1.7 0.54 10.1 1.7 2.0 1 0 0 1 1 1 0 PHD-finger DAGK_acc PF00609.17 MSTRG.21786.1_3 - 3.7e-47 160.5 0.0 6.2e-47 159.8 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.22 MSTRG.21786.1_3 - 9.5e-27 93.0 0.0 1.7e-26 92.2 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.20 MSTRG.21786.1_3 - 9.8e-14 50.9 26.6 6.6e-11 41.8 14.0 2.8 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Ank_2 PF12796.5 MSTRG.21786.1_3 - 2.5e-10 40.7 0.2 0.00024 21.5 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.21786.1_3 - 2.8e-10 40.4 0.3 0.0001 22.6 0.1 3.0 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.4 MSTRG.21786.1_3 - 2.1e-06 27.8 0.0 0.018 15.3 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.21786.1_3 - 2.6e-06 27.2 0.1 0.5 10.9 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.28 MSTRG.21786.1_3 - 1.9e-05 24.8 0.1 0.0096 16.2 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat PHD_2 PF13831.4 MSTRG.21786.1_3 - 4.2 6.8 6.3 3.3 7.2 0.5 2.8 2 0 0 2 2 2 0 PHD-finger L27_2 PF09045.8 MSTRG.11884.1_2 - 5.9e-35 118.9 6.5 1.4e-34 117.7 6.5 1.6 1 0 0 1 1 1 1 L27_2 PDZ PF00595.22 MSTRG.11884.1_2 - 2.2e-30 104.7 6.1 4.9e-15 55.5 0.6 2.5 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.11884.1_2 - 2.6e-10 40.3 2.2 0.00058 20.0 0.1 2.8 2 1 1 3 3 3 2 PDZ domain L27_1 PF09058.8 MSTRG.11884.1_2 - 1.4e-05 24.9 0.6 3.3e-05 23.8 0.6 1.6 1 0 0 1 1 1 1 L27_1 L27 PF02828.14 MSTRG.11884.1_2 - 0.013 15.1 1.3 0.028 14.1 1.3 1.5 1 0 0 1 1 1 0 L27 domain Ribosomal_60s PF00428.17 MSTRG.11884.1_2 - 0.031 14.7 0.3 0.07 13.6 0.3 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein TetR_C_11 PF16859.3 MSTRG.11884.1_2 - 0.057 13.6 0.1 0.2 11.9 0.0 1.9 2 0 0 2 2 2 0 Bacterial transcriptional repressor C-terminal DUF1687 PF07955.9 MSTRG.11884.1_2 - 0.097 13.0 0.5 3.5 8.0 0.2 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1687) DUF4744 PF15918.3 MSTRG.11884.1_3 - 0.11 13.2 1.3 0.24 12.1 1.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4744) ATP-gua_Ptrans PF00217.17 MSTRG.16413.1_1 - 3.9e-96 321.3 0.0 5e-96 320.9 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.13 MSTRG.16413.1_1 - 7.1e-34 115.9 0.0 1.3e-33 115.0 0.0 1.5 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain Cyclin_N PF00134.21 MSTRG.9541.2_1 - 3.8e-19 68.6 0.0 9.6e-19 67.3 0.0 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain V-set PF07686.15 MSTRG.18831.1_1 - 5.5e-10 39.2 0.1 2.6e-08 33.9 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 MSTRG.18831.1_1 - 2.7e-09 37.4 0.0 0.00043 20.7 0.0 3.0 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 MSTRG.18831.1_1 - 1.8e-06 27.9 0.0 0.017 15.2 0.0 2.9 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.18831.1_1 - 3.3e-06 27.2 0.0 0.086 13.1 0.0 3.1 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 MSTRG.18831.1_1 - 0.0058 16.5 0.0 3.5 7.6 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin I-set domain C1-set PF07654.13 MSTRG.18831.1_1 - 0.01 16.2 0.0 0.035 14.4 0.0 2.0 1 0 0 1 1 1 0 Immunoglobulin C1-set domain WD40 PF00400.30 MSTRG.24866.1_2 - 1.2e-17 63.8 3.2 0.00026 21.6 0.0 6.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.24866.1_2 - 0.00043 20.4 0.0 6.8 6.9 0.0 4.1 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain THAP PF05485.10 MSTRG.1868.1_2 - 1.3e-13 51.6 0.6 4.3e-13 49.9 0.5 1.9 2 0 0 2 2 2 1 THAP domain Tnp_P_element PF12017.6 MSTRG.1868.1_2 - 3.2e-05 23.4 0.0 5.2e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Transposase protein L51_S25_CI-B8 PF05047.14 MSTRG.20695.2_2 - 4.9e-15 55.0 0.0 7.1e-15 54.5 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Nsp1 PF11501.6 MSTRG.20695.2_2 - 0.036 14.0 0.0 0.049 13.6 0.0 1.2 1 0 0 1 1 1 0 Non structural protein Nsp1 Myb_DNA-bind_4 PF13837.4 MSTRG.19425.1_2 - 1.9e-09 37.7 4.0 3.7e-09 36.7 4.0 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.7 MSTRG.19425.1_2 - 8.7e-05 22.6 2.0 0.00025 21.1 2.0 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like MIP PF00230.18 MSTRG.2206.1_1 - 1.1e-76 257.4 16.3 1.4e-76 257.1 16.3 1.1 1 0 0 1 1 1 1 Major intrinsic protein Calsequestrin PF01216.15 MSTRG.4253.1_2 - 1.8e-158 527.5 73.4 5.2e-157 522.7 73.4 2.1 1 1 0 1 1 1 1 Calsequestrin Thioredoxin_6 PF13848.4 MSTRG.4253.1_2 - 1.3e-22 80.5 2.6 6.1e-19 68.6 0.8 2.4 2 0 0 2 2 2 2 Thioredoxin-like domain SDA1 PF05285.10 MSTRG.4253.1_2 - 0.0075 15.6 26.9 0.011 15.1 26.9 1.2 1 0 0 1 1 1 1 SDA1 Na_sulph_symp PF00939.17 MSTRG.895.1_2 - 4.4e-66 223.7 3.8 5.7e-66 223.3 3.8 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.14 MSTRG.895.1_2 - 6e-28 97.8 13.5 2.2e-15 56.6 0.9 2.0 1 1 1 2 2 2 2 Citrate transporter Acatn PF13000.5 MSTRG.4302.2_3 - 8.8e-113 377.5 16.9 7.5e-81 272.1 11.1 3.2 1 1 0 2 2 2 2 Acetyl-coenzyme A transporter 1 RDD PF06271.10 MSTRG.4302.2_3 - 0.023 14.8 2.1 0.1 12.6 1.0 2.7 2 0 0 2 2 2 0 RDD family Scramblase PF03803.13 MSTRG.11090.2_2 - 2.9e-84 281.7 0.0 3.9e-84 281.2 0.0 1.1 1 0 0 1 1 1 1 Scramblase Med4 PF10018.7 MSTRG.8570.1_2 - 2.4e-10 40.3 10.5 3.4e-10 39.8 10.5 1.3 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 HMMR_N PF15905.3 MSTRG.8570.1_2 - 0.00069 19.1 10.8 0.00071 19.0 10.5 1.3 1 1 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal RmuC PF02646.14 MSTRG.8570.1_2 - 0.0038 16.3 5.9 0.0057 15.7 5.9 1.3 1 0 0 1 1 1 1 RmuC family RPW8 PF05659.9 MSTRG.8570.1_2 - 0.0081 15.7 1.6 0.0081 15.7 1.6 1.8 2 0 0 2 2 2 1 Arabidopsis broad-spectrum mildew resistance protein RPW8 Phage_GP20 PF06810.9 MSTRG.8570.1_2 - 0.016 14.9 5.9 0.025 14.2 5.9 1.3 1 0 0 1 1 1 0 Phage minor structural protein GP20 Phage_GPO PF05929.9 MSTRG.8570.1_2 - 0.017 14.7 4.9 0.02 14.4 4.9 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF4094 PF13334.4 MSTRG.8570.1_2 - 0.04 14.2 1.6 0.062 13.6 1.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) DUF3461 PF11944.6 MSTRG.8570.1_2 - 0.055 13.5 8.0 0.074 13.1 5.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3461) DUF641 PF04859.10 MSTRG.8570.1_2 - 0.062 13.5 7.0 0.07 13.3 6.3 1.6 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) ADIP PF11559.6 MSTRG.8570.1_2 - 0.069 13.1 9.3 0.14 12.1 9.3 1.5 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding AATF-Che1 PF13339.4 MSTRG.8570.1_2 - 0.12 13.0 6.5 0.17 12.4 3.5 2.0 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor Sec8_exocyst PF04048.12 MSTRG.8570.1_2 - 0.13 12.0 7.6 2 8.2 0.1 2.2 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain FAM76 PF16046.3 MSTRG.8570.1_2 - 0.14 11.3 3.9 0.13 11.4 3.9 1.1 1 0 0 1 1 1 0 FAM76 protein CREPT PF16566.3 MSTRG.8570.1_2 - 0.16 12.0 9.0 0.21 11.6 8.8 1.4 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour DASH_Hsk3 PF08227.9 MSTRG.8570.1_2 - 0.21 11.8 0.4 0.21 11.8 0.4 2.5 2 1 0 2 2 2 0 DASH complex subunit Hsk3 like DUF724 PF05266.12 MSTRG.8570.1_2 - 0.22 11.2 9.2 0.17 11.6 7.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Alanine_zipper PF11839.6 MSTRG.8570.1_2 - 0.23 11.6 5.3 0.13 12.5 3.1 1.6 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein ERM PF00769.17 MSTRG.8570.1_2 - 0.32 10.7 14.5 0.38 10.4 14.5 1.3 1 1 0 1 1 1 0 Ezrin/radixin/moesin family TMPIT PF07851.11 MSTRG.8570.1_2 - 0.47 9.5 5.4 0.7 8.9 5.4 1.3 1 0 0 1 1 1 0 TMPIT-like protein Atg14 PF10186.7 MSTRG.8570.1_2 - 0.64 8.9 9.1 0.82 8.6 9.1 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ISG65-75 PF11727.6 MSTRG.8570.1_2 - 0.66 9.0 7.1 0.53 9.3 6.1 1.4 2 0 0 2 2 2 0 Invariant surface glycoprotein DUF2019 PF09450.8 MSTRG.8570.1_2 - 0.73 9.7 7.0 6 6.7 4.5 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF2019) DUF948 PF06103.9 MSTRG.8570.1_2 - 0.87 9.8 4.4 9.2 6.5 1.1 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Cob_adeno_trans PF01923.16 MSTRG.8570.1_2 - 0.88 9.6 5.6 2.9 7.9 5.6 1.7 1 1 0 1 1 1 0 Cobalamin adenosyltransferase AAA_23 PF13476.4 MSTRG.8570.1_2 - 1.1 9.6 6.5 1.2 9.5 6.5 1.2 1 0 0 1 1 1 0 AAA domain XhlA PF10779.7 MSTRG.8570.1_2 - 1.9 8.6 5.7 0.55 10.3 1.9 2.1 3 0 0 3 3 2 0 Haemolysin XhlA zf-CpG_bind_C PF12269.6 MSTRG.8570.1_2 - 3.2 7.3 8.4 1.1 8.9 6.1 1.4 2 0 0 2 2 2 0 CpG binding protein zinc finger C terminal domain E2F_CC-MB PF16421.3 MSTRG.8570.1_2 - 3.4 8.1 8.9 0.34 11.2 4.6 1.6 2 0 0 2 2 1 0 E2F transcription factor CC-MB domain ABC_tran_CTD PF16326.3 MSTRG.8570.1_2 - 8.8 6.5 13.6 1.7 8.8 8.3 2.4 2 1 1 3 3 3 0 ABC transporter C-terminal domain IL6 PF00489.15 MSTRG.3677.1_2 - 2.1 7.7 5.0 3.2 7.2 5.0 1.1 1 0 0 1 1 1 0 Interleukin-6/G-CSF/MGF family ABC2_membrane_3 PF12698.5 MSTRG.2082.1_1 - 2.3 7.1 6.1 3.2 6.6 6.1 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Trypsin PF00089.24 MSTRG.18043.2_2 - 1.5e-65 221.0 0.3 2.6e-65 220.2 0.3 1.4 1 0 0 1 1 1 1 Trypsin SRCR_2 PF15494.4 MSTRG.18043.2_2 - 8.8e-22 77.3 0.4 1.6e-21 76.5 0.4 1.4 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR PF00530.16 MSTRG.18043.2_2 - 2.7e-05 24.5 0.1 5.6e-05 23.4 0.1 1.5 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Ldl_recept_a PF00057.16 MSTRG.18043.2_2 - 0.00013 22.0 2.9 0.0003 20.8 2.9 1.7 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Trypsin_2 PF13365.4 MSTRG.18043.2_2 - 0.00043 21.1 0.0 0.00087 20.1 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 MSTRG.18043.2_2 - 0.0064 16.7 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Hepsin-SRCR PF09272.8 MSTRG.18043.2_2 - 0.058 13.6 0.2 0.11 12.7 0.2 1.3 1 0 0 1 1 1 0 Hepsin, SRCR CPSase_L_D2 PF02786.15 MSTRG.15043.2_1 - 2.3e-112 373.5 0.5 2.6e-83 278.5 0.0 2.5 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain OTCace_N PF02729.19 MSTRG.15043.2_1 - 5.2e-45 152.8 0.3 1.1e-44 151.8 0.3 1.6 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.17 MSTRG.15043.2_1 - 5.2e-41 139.7 0.1 2.9e-40 137.3 0.2 2.3 2 0 0 2 2 2 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.22 MSTRG.15043.2_1 - 1.6e-35 122.4 1.1 5.6e-35 120.6 0.2 2.5 3 0 0 3 3 3 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain ATP-grasp PF02222.20 MSTRG.15043.2_1 - 1.6e-18 66.7 0.6 1.5e-10 40.8 0.1 2.8 3 0 0 3 3 3 2 ATP-grasp domain Dala_Dala_lig_C PF07478.11 MSTRG.15043.2_1 - 1.8e-18 66.7 2.5 9.9e-10 38.1 0.2 2.7 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus MGS PF02142.20 MSTRG.15043.2_1 - 4.9e-18 65.0 0.0 3.6e-17 62.2 0.0 2.4 2 0 0 2 2 2 1 MGS-like domain ATPgrasp_Ter PF15632.4 MSTRG.15043.2_1 - 1.6e-13 49.9 0.5 0.00014 20.5 0.0 3.5 3 0 0 3 3 3 3 ATP-grasp in the biosynthetic pathway with Ter operon Amidohydro_1 PF01979.18 MSTRG.15043.2_1 - 5.1e-11 42.3 0.2 5.3e-09 35.7 0.0 3.3 3 1 0 3 3 3 1 Amidohydrolase family ATP-grasp_3 PF02655.12 MSTRG.15043.2_1 - 1.6e-07 31.4 1.0 0.012 15.6 0.1 2.5 2 0 0 2 2 2 2 ATP-grasp domain GARS_A PF01071.17 MSTRG.15043.2_1 - 0.006 16.2 1.4 0.017 14.7 0.0 2.5 3 0 0 3 3 3 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GSH-S_ATP PF02955.14 MSTRG.15043.2_1 - 0.014 14.7 0.0 0.031 13.6 0.0 1.5 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, ATP-grasp domain ATP-grasp_5 PF13549.4 MSTRG.15043.2_1 - 0.024 13.9 0.0 3.3 7.0 0.1 2.5 2 0 0 2 2 2 0 ATP-grasp domain BIRC6 PF12356.6 MSTRG.14585.2_3 - 3.4e-69 231.6 1.8 3.4e-69 231.6 1.8 1.9 2 0 0 2 2 2 1 Baculoviral IAP repeat-containing protein 6 UQ_con PF00179.24 MSTRG.14585.2_3 - 9.9e-31 106.1 0.0 2.1e-30 105.0 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.11 MSTRG.14585.2_3 - 9.6e-05 22.1 0.0 0.00022 20.9 0.0 1.5 1 0 0 1 1 1 1 UEV domain FAM217 PF15344.4 MSTRG.6351.3_3 - 4.4e-58 196.9 0.6 4.4e-58 196.9 0.6 2.0 2 0 0 2 2 2 1 FAM217 family DUF4125 PF13526.4 MSTRG.6351.3_3 - 7.5e-05 22.3 0.0 0.00011 21.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4125) ANAPC10 PF03256.14 MSTRG.22850.2_2 - 0.025 14.1 0.2 0.042 13.3 0.2 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex, subunit 10 (APC10) ubiquitin PF00240.21 MSTRG.22850.2_3 - 2.5e-70 232.0 4.2 2.2e-34 116.9 0.3 2.1 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.6 MSTRG.22850.2_3 - 2e-34 117.1 4.6 1.8e-16 59.6 0.4 2.1 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 MSTRG.22850.2_3 - 6.7e-14 52.0 1.4 1.4e-05 25.3 0.1 3.2 2 2 0 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 MSTRG.22850.2_3 - 1.9e-07 31.0 0.3 0.03 14.3 0.0 2.7 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 MSTRG.22850.2_3 - 1.2e-05 25.7 0.0 0.24 11.8 0.0 2.3 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Telomere_Sde2 PF13019.4 MSTRG.22850.2_3 - 0.00048 19.9 0.0 0.94 9.2 0.0 2.1 1 1 1 2 2 2 2 Telomere stability and silencing FERM_f0 PF16511.3 MSTRG.22850.2_3 - 0.0045 17.1 3.2 14 6.0 0.2 3.9 2 2 0 2 2 2 0 N-terminal or F0 domain of Talin-head FERM DUF2870 PF11069.6 MSTRG.22850.2_3 - 0.0053 16.9 0.0 6.2 7.1 0.0 2.7 2 2 0 2 2 2 2 Protein of unknown function (DUF2870) RBD PF02196.13 MSTRG.22850.2_3 - 0.024 14.6 0.0 10 6.2 0.0 2.3 2 0 0 2 2 2 0 Raf-like Ras-binding domain PI3K_rbd PF00794.16 MSTRG.22850.2_3 - 0.032 14.3 1.1 5.9 7.0 0.1 2.5 2 1 0 2 2 2 0 PI3-kinase family, ras-binding domain FlgD_ig PF13860.4 MSTRG.22850.2_3 - 0.046 13.4 0.3 14 5.5 0.0 2.4 2 0 0 2 2 2 0 FlgD Ig-like domain DUF3861 PF12977.5 MSTRG.22850.2_3 - 0.073 13.1 0.1 15 5.7 0.0 2.3 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) TraK PF06586.9 MSTRG.22850.2_3 - 0.098 12.2 0.0 5.4 6.5 0.0 2.1 2 0 0 2 2 2 0 TraK protein Plexin_cytopl PF08337.10 MSTRG.22850.2_3 - 0.18 10.3 2.0 6.9 5.1 0.1 2.7 2 1 0 2 2 2 0 Plexin cytoplasmic RasGAP domain OB_NTP_bind PF07717.14 MSTRG.17786.1_2 - 4.5e-17 62.1 0.0 7.7e-17 61.3 0.0 1.3 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold LMWPc PF01451.19 MSTRG.9655.2_2 - 1.1e-42 145.7 0.0 1.6e-42 145.1 0.0 1.3 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Ig_3 PF13927.4 MSTRG.17798.1_2 - 6.1e-42 142.0 0.1 2.7e-11 43.8 0.1 4.3 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.14 MSTRG.17798.1_2 - 5.4e-35 119.2 0.0 6e-13 48.5 0.0 4.4 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.17798.1_2 - 9.3e-26 89.9 0.0 4.8e-05 23.5 0.0 4.2 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.23 MSTRG.17798.1_2 - 3.8e-22 78.1 0.0 9e-07 28.8 0.1 5.1 4 2 0 4 4 4 3 Immunoglobulin domain V-set PF07686.15 MSTRG.17798.1_2 - 4.1e-17 62.2 6.0 0.19 11.8 0.0 7.6 4 4 3 7 7 7 5 Immunoglobulin V-set domain C2-set_2 PF08205.10 MSTRG.17798.1_2 - 9.1e-06 25.5 0.9 0.13 12.3 0.1 3.1 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain BiPBP_C PF06832.10 MSTRG.17798.1_2 - 0.0015 18.4 0.0 0.5 10.3 0.0 3.1 3 0 0 3 3 3 1 Penicillin-Binding Protein C-terminus Family Izumo-Ig PF16706.3 MSTRG.17798.1_2 - 0.013 15.3 0.0 20 5.2 0.0 3.9 4 1 0 4 4 4 0 Izumo-like Immunoglobulin domain Herpes_gE PF02480.14 MSTRG.17798.1_2 - 0.034 12.8 0.0 0.18 10.4 0.0 2.1 2 1 0 2 2 2 0 Alphaherpesvirus glycoprotein E C2-set PF05790.13 MSTRG.17798.1_2 - 0.081 13.0 0.0 1.4 9.1 0.0 2.7 3 0 0 3 3 3 0 Immunoglobulin C2-set domain I-set PF07679.14 MSTRG.223.1_1 - 4e-20 71.5 0.0 6e-20 71.0 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.223.1_1 - 2.1e-09 37.7 0.0 4.2e-09 36.8 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.223.1_1 - 6.1e-06 26.4 0.0 1.3e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 MSTRG.223.1_1 - 0.0023 17.9 0.0 0.0038 17.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Big_3_5 PF16640.3 MSTRG.223.1_1 - 0.021 14.9 0.5 0.3 11.2 0.5 2.3 1 1 0 1 1 1 0 Bacterial Ig-like domain (group 3) Pyrid_oxidase_2 PF13883.4 MSTRG.22340.1_3 - 9.3e-53 178.6 0.0 1.3e-52 178.0 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxidase PF01243.18 MSTRG.22340.1_3 - 0.005 16.9 0.0 0.0084 16.1 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase CRAL_TRIO PF00650.18 MSTRG.22985.2_3 - 4.8e-32 110.7 0.5 7.6e-32 110.1 0.5 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.4 MSTRG.22985.2_3 - 1.8e-05 24.7 0.4 3.2e-05 23.9 0.4 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain UCH PF00443.27 MSTRG.17458.2_3 - 1.2e-77 260.7 3.0 2.6e-77 259.7 3.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP8_dimer PF08969.9 MSTRG.17458.2_3 - 5.3e-27 94.2 3.5 1.5e-26 92.7 3.5 1.9 1 0 0 1 1 1 1 USP8 dimerisation domain UCH_1 PF13423.4 MSTRG.17458.2_3 - 6.4e-24 85.0 1.1 2.6e-23 83.0 1.1 2.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.18 MSTRG.17458.2_3 - 0.0011 19.3 0.0 0.0029 18.0 0.0 1.8 1 0 0 1 1 1 1 Rhodanese-like domain ILEI PF15711.3 MSTRG.6664.2_3 - 9.2e-11 41.9 0.0 1.6e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 Interleukin-like EMT inducer MARVEL PF01284.21 MSTRG.18411.2_3 - 1.8e-10 40.9 15.4 1.8e-10 40.9 15.4 2.1 2 0 0 2 2 2 1 Membrane-associating domain FF PF01846.17 MSTRG.1134.4_2 - 8.5e-44 147.4 23.4 6.8e-17 61.2 0.2 6.1 6 0 0 6 6 6 5 FF domain WW PF00397.24 MSTRG.1134.4_2 - 1.6e-19 69.4 17.4 8.6e-10 38.3 4.4 2.7 2 0 0 2 2 2 2 WW domain Na_H_Exchanger PF00999.19 MSTRG.21558.1_2 - 1e-79 268.0 44.8 1.2e-79 267.7 44.8 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family NEXCaM_BD PF16644.3 MSTRG.21558.1_2 - 1.4e-05 25.2 3.4 3.5e-05 23.9 3.4 1.6 1 0 0 1 1 1 1 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin PIG-H PF10181.7 MSTRG.21558.1_2 - 0.6 9.9 4.6 0.2 11.4 0.3 2.3 2 0 0 2 2 2 0 GPI-GlcNAc transferase complex, PIG-H component MT PF12777.5 MSTRG.17055.1_2 - 0.0023 16.9 0.0 0.0024 16.9 0.0 1.0 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor COG6 PF06419.9 MSTRG.17055.1_2 - 0.12 10.5 0.0 0.13 10.4 0.0 1.1 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 PTEN_C2 PF10409.7 MSTRG.9495.1_1 - 3.1e-25 88.4 0.0 5.7e-25 87.5 0.0 1.5 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.18 MSTRG.9495.1_1 - 2.3e-07 30.6 0.0 5e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 MSTRG.9495.1_1 - 0.0014 18.1 0.0 0.004 16.6 0.0 1.7 1 1 1 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.4 MSTRG.9495.1_1 - 0.0029 17.6 0.0 0.0051 16.8 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate DUF1242 PF06842.10 MSTRG.13829.1_1 - 8e-11 41.4 1.1 1.4e-10 40.6 1.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) DUF747 PF05346.9 MSTRG.17867.1_2 - 3.1e-46 158.2 7.4 4.2e-46 157.7 7.4 1.1 1 0 0 1 1 1 1 Eukaryotic membrane protein family SelP_N PF04592.12 MSTRG.17867.1_2 - 3.9 6.7 12.0 5.7 6.1 12.0 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region IncA PF04156.12 MSTRG.1360.1_2 - 0.0055 16.4 1.6 0.0055 16.4 1.6 2.6 2 1 0 2 2 2 1 IncA protein MerR-DNA-bind PF09278.9 MSTRG.1360.1_2 - 0.071 13.5 0.1 0.071 13.5 0.1 4.7 4 1 1 5 5 5 0 MerR, DNA binding Spc7 PF08317.9 MSTRG.1360.1_2 - 0.15 10.8 8.5 0.087 11.6 0.2 2.7 2 2 0 2 2 2 0 Spc7 kinetochore protein Katanin_con80 PF13925.4 MSTRG.15299.1_2 - 5.7e-30 104.3 0.2 8.6e-30 103.7 0.2 1.3 1 0 0 1 1 1 1 con80 domain of Katanin Cwf_Cwc_15 PF04889.10 MSTRG.23988.1_3 - 0.44 10.1 4.2 0.6 9.7 4.2 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein ThiF PF00899.19 MSTRG.20279.1_3 - 5.3e-117 389.3 0.0 3.7e-72 242.5 0.0 2.1 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.7 MSTRG.20279.1_3 - 8.7e-94 314.0 0.1 1.4e-93 313.4 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.8 MSTRG.20279.1_3 - 2e-35 121.3 0.1 4e-35 120.3 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin fold domain E1_FCCH PF16190.3 MSTRG.20279.1_3 - 3.2e-33 113.6 0.1 6.1e-33 112.7 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.3 MSTRG.20279.1_3 - 3.6e-26 91.0 0.1 9e-26 89.7 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle PH PF00169.27 MSTRG.1941.1_2 - 2.9e-19 69.4 0.0 5.3e-19 68.6 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 MSTRG.1941.1_2 - 2e-06 27.9 0.0 3.3e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.4 MSTRG.1941.1_2 - 0.00023 21.4 1.9 0.016 15.5 0.7 2.8 2 1 0 2 2 2 1 Pleckstrin homology domain PH_6 PF15406.4 MSTRG.1941.1_2 - 0.02 15.1 0.0 0.042 14.0 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain SR-25 PF10500.7 MSTRG.1941.1_2 - 0.053 13.0 7.8 0.076 12.5 7.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Lon_C PF05362.11 MSTRG.8466.1_1 - 7.1e-73 244.4 0.0 1.6e-72 243.2 0.0 1.6 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.14 MSTRG.8466.1_1 - 7.8e-31 107.4 0.2 1.4e-30 106.6 0.2 1.5 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.27 MSTRG.8466.1_1 - 4.5e-24 85.2 0.0 1.1e-23 84.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.12 MSTRG.8466.1_1 - 9.6e-09 35.2 0.0 3.9e-08 33.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.10 MSTRG.8466.1_1 - 5.6e-07 28.9 0.0 1.6e-05 24.2 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.12 MSTRG.8466.1_1 - 6.2e-07 29.6 0.0 1.6e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.4 MSTRG.8466.1_1 - 3.3e-06 27.5 1.4 2.1e-05 24.8 0.0 2.8 3 1 0 3 3 3 1 AAA ATPase domain ChlI PF13541.4 MSTRG.8466.1_1 - 6.5e-06 25.9 0.0 1.4e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_PrkA PF08298.9 MSTRG.8466.1_1 - 7.7e-06 24.9 0.0 1.4e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain AAA_22 PF13401.4 MSTRG.8466.1_1 - 0.00013 22.1 0.2 0.0028 17.8 0.0 2.8 2 1 0 2 2 1 1 AAA domain AAA_23 PF13476.4 MSTRG.8466.1_1 - 0.0013 19.2 4.7 0.29 11.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.20 MSTRG.8466.1_1 - 0.0024 18.1 0.0 0.0054 17.0 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.4 MSTRG.8466.1_1 - 0.0062 16.4 0.0 0.019 14.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.15 MSTRG.8466.1_1 - 0.0088 15.7 0.0 0.02 14.6 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.4 MSTRG.8466.1_1 - 0.01 16.2 0.4 0.038 14.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain LXG PF04740.10 MSTRG.8466.1_1 - 0.031 13.8 0.2 2.2 7.8 0.0 3.0 3 0 0 3 3 3 0 LXG domain of WXG superfamily DUF258 PF03193.14 MSTRG.8466.1_1 - 0.036 13.8 0.0 0.12 12.1 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function, DUF258 NTPase_1 PF03266.13 MSTRG.8466.1_1 - 0.043 13.6 0.1 0.67 9.7 0.0 2.4 1 1 1 2 2 2 0 NTPase Parvo_NS1 PF01057.15 MSTRG.8466.1_1 - 0.05 12.5 0.0 0.42 9.5 0.0 2.1 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_17 PF13207.4 MSTRG.8466.1_1 - 0.065 13.5 1.0 1.3 9.3 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.4 MSTRG.8466.1_1 - 0.068 12.8 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.15 MSTRG.8466.1_1 - 0.08 12.8 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_11 PF13086.4 MSTRG.8466.1_1 - 0.082 12.5 1.8 1.8 8.1 0.0 2.6 3 0 0 3 3 3 0 AAA domain NACHT PF05729.10 MSTRG.8466.1_1 - 0.083 12.7 0.0 0.21 11.3 0.0 1.8 1 1 0 1 1 1 0 NACHT domain NB-ARC PF00931.20 MSTRG.8466.1_1 - 0.11 11.4 1.0 0.13 11.1 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain AAA_30 PF13604.4 MSTRG.8466.1_1 - 0.11 12.0 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.16 MSTRG.8466.1_1 - 0.15 11.8 5.8 1 9.1 0.0 3.4 2 2 0 3 3 3 0 ATPase domain predominantly from Archaea WD40 PF00400.30 MSTRG.5533.4_3 - 9.6e-05 23.0 5.7 0.018 15.7 0.1 5.0 4 1 1 5 5 5 1 WD domain, G-beta repeat DUF3694 PF12473.6 MSTRG.5533.4_3 - 0.079 13.5 0.1 0.13 12.8 0.1 1.3 1 0 0 1 1 1 0 Kinesin protein DUF4639 PF15479.4 MSTRG.5533.4_3 - 0.12 11.2 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4639) PapJ PF14855.4 MSTRG.5533.4_3 - 0.14 11.7 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Pilus-assembly fibrillin subunit, chaperone GARS_A PF01071.17 MSTRG.20134.1_2 - 8.7e-89 296.3 0.0 1.4e-88 295.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Formyl_trans_N PF00551.17 MSTRG.20134.1_2 - 3.9e-62 209.1 0.0 6.2e-62 208.4 0.0 1.3 1 0 0 1 1 1 1 Formyl transferase GARS_N PF02844.13 MSTRG.20134.1_2 - 5.5e-35 119.9 1.8 3.1e-33 114.3 0.4 2.7 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, N domain AIRS_C PF02769.20 MSTRG.20134.1_2 - 1.2e-32 113.1 0.0 4.3e-32 111.3 0.0 2.0 2 0 0 2 2 2 1 AIR synthase related protein, C-terminal domain GARS_C PF02843.14 MSTRG.20134.1_2 - 5.7e-27 93.7 3.3 8.3e-27 93.2 1.1 2.6 3 0 0 3 3 3 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.22 MSTRG.20134.1_2 - 1.9e-14 53.9 2.5 1.9e-14 53.9 2.5 2.4 3 0 0 3 3 1 1 AIR synthase related protein, N-terminal domain ATPgrasp_Ter PF15632.4 MSTRG.20134.1_2 - 8.5e-09 34.4 0.0 1.7e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.12 MSTRG.20134.1_2 - 0.00046 20.1 0.0 0.00084 19.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.15 MSTRG.20134.1_2 - 0.00073 19.0 0.1 0.0016 17.9 0.1 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp PF02222.20 MSTRG.20134.1_2 - 0.0011 18.4 0.0 0.002 17.6 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.4 MSTRG.20134.1_2 - 0.02 14.4 0.0 0.038 13.4 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp_2 PF08442.8 MSTRG.20134.1_2 - 0.081 12.3 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain RimK PF08443.9 MSTRG.20134.1_2 - 0.13 11.7 0.0 0.3 10.5 0.0 1.5 1 0 0 1 1 1 0 RimK-like ATP-grasp domain ABC_membrane PF00664.21 MSTRG.19021.1_1 - 3.3e-34 118.7 5.2 4.3e-34 118.3 5.2 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region CD20 PF04103.13 MSTRG.18504.1_3 - 4.4e-07 30.0 9.0 4.4e-07 30.0 9.0 1.8 1 1 1 2 2 2 1 CD20-like family Arrestin_N PF00339.27 MSTRG.22417.4_3 - 2.3e-26 92.5 1.4 1.4e-23 83.5 0.1 2.2 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.20 MSTRG.22417.4_3 - 1.9e-19 70.2 3.0 9e-18 64.8 1.1 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Pkinase PF00069.23 MSTRG.3000.2_2 - 1.1e-33 116.6 0.0 1.7e-33 116.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.3000.2_2 - 2.1e-19 69.7 0.0 3.2e-19 69.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.3000.2_2 - 4.8e-05 22.7 0.0 6.6e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.21 MSTRG.3000.2_2 - 0.0082 16.0 0.2 0.013 15.3 0.2 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.20 MSTRG.3000.2_2 - 0.027 13.9 0.0 0.049 13.1 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.12 MSTRG.3000.2_2 - 0.05 12.8 0.1 0.074 12.3 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Fasciclin PF02469.20 MSTRG.3000.2_3 - 0.025 14.7 0.0 0.038 14.1 0.0 1.2 1 0 0 1 1 1 0 Fasciclin domain SPAR_C PF11881.6 MSTRG.17979.1_2 - 2.4e-79 266.5 5.2 5.5e-79 265.3 5.2 1.6 1 0 0 1 1 1 1 C-terminal domain of SPAR protein Rap_GAP PF02145.13 MSTRG.17979.1_2 - 2.2e-66 222.9 0.3 3.6e-66 222.2 0.3 1.4 1 0 0 1 1 1 1 Rap/ran-GAP PDZ PF00595.22 MSTRG.17979.1_2 - 0.0018 18.4 0.0 0.0037 17.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) TMF_TATA_bd PF12325.6 MSTRG.17979.1_2 - 0.0031 17.6 1.0 0.0092 16.1 1.0 1.7 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding IncA PF04156.12 MSTRG.17979.1_2 - 0.029 14.1 0.0 0.054 13.1 0.0 1.3 1 0 0 1 1 1 0 IncA protein DUF2046 PF09755.7 MSTRG.17979.1_2 - 0.034 13.3 0.8 0.057 12.5 0.8 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) CENP-K PF11802.6 MSTRG.17979.1_2 - 0.14 11.6 1.0 0.23 10.9 1.0 1.2 1 0 0 1 1 1 0 Centromere-associated protein K AXH PF08517.10 MSTRG.19711.1_3 - 2.4e-40 137.5 0.1 4e-40 136.8 0.1 1.3 1 0 0 1 1 1 1 Ataxin-1 and HBP1 module (AXH) ATXN-1_C PF12547.6 MSTRG.19711.1_3 - 2.3e-19 69.3 2.8 2.3e-19 69.3 2.8 2.3 2 0 0 2 2 2 1 Capicua transcriptional repressor modulator RasGEF PF00617.17 MSTRG.1964.1_3 - 2.7e-57 193.6 0.1 3.7e-57 193.1 0.1 1.2 1 0 0 1 1 1 1 RasGEF domain DUF2462 PF09495.8 MSTRG.19117.1_2 - 1e-19 70.9 14.1 1.6e-19 70.3 14.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2462) Zn_Tnp_IS1 PF03811.11 MSTRG.23042.2_2 - 0.1 12.2 3.3 0.087 12.4 0.4 2.6 2 0 0 2 2 2 0 InsA N-terminal domain Ldl_recept_a PF00057.16 MSTRG.23042.2_3 - 3.9e-102 334.0 240.2 6.2e-13 48.6 6.1 15.3 16 0 0 16 16 16 11 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.15 MSTRG.23042.2_3 - 1.7e-43 146.7 3.0 3.7e-13 49.6 0.1 6.0 6 0 0 6 6 6 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 MSTRG.23042.2_3 - 9.5e-11 41.7 10.8 9.5e-11 41.7 10.8 13.5 8 2 5 13 13 13 4 Coagulation Factor Xa inhibitory site EGF PF00008.25 MSTRG.23042.2_3 - 0.00017 21.7 25.5 0.0011 19.1 4.9 19.4 19 3 2 21 21 21 7 EGF-like domain EGF_2 PF07974.11 MSTRG.23042.2_3 - 0.0024 18.1 11.9 0.0024 18.1 11.9 16.8 15 2 2 17 17 17 5 EGF-like domain DUF3377 PF11857.6 MSTRG.23042.2_3 - 0.01 15.6 0.1 0.019 14.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) hEGF PF12661.5 MSTRG.23042.2_3 - 0.011 16.3 6.3 0.011 16.3 6.3 18.2 18 0 0 18 18 18 0 Human growth factor-like EGF SKG6 PF08693.8 MSTRG.23042.2_3 - 0.033 13.5 0.8 0.06 12.6 0.8 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain TadE PF07811.10 MSTRG.23042.2_3 - 0.034 14.3 1.5 0.056 13.6 1.5 1.3 1 0 0 1 1 1 0 TadE-like protein zf-C3HC4_3 PF13920.4 MSTRG.5259.3_1 - 2.1e-14 52.9 9.4 2.1e-14 52.9 9.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 MSTRG.5259.3_1 - 1.3e-06 28.0 10.2 1.3e-06 28.0 10.2 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.4 MSTRG.5259.3_1 - 1.1e-05 25.5 11.7 1.1e-05 25.5 11.7 2.1 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.4 MSTRG.5259.3_1 - 0.00097 18.9 9.5 0.00097 18.9 9.5 2.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.4 MSTRG.5259.3_1 - 0.0025 17.5 11.3 0.0025 17.5 11.3 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.4 MSTRG.5259.3_1 - 1.5 8.5 8.2 3.4 7.3 8.2 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.3 MSTRG.5259.3_1 - 2.9 7.6 9.0 0.38 10.4 0.9 3.2 3 0 0 3 3 3 0 RING-like zinc finger zf-P11 PF03854.12 MSTRG.5259.3_1 - 6.1 6.5 13.1 21 4.7 13.1 1.9 1 1 0 1 1 1 0 P-11 zinc finger Cadherin PF00028.15 MSTRG.2419.1_1 - 2.9e-22 78.8 1.0 1.8e-10 41.0 0.3 3.6 3 0 0 3 3 3 3 Cadherin domain PTS_2-RNA PF01885.14 MSTRG.7303.2_1 - 0.001 19.0 0.1 0.0015 18.5 0.1 1.2 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family PTS_2-RNA PF01885.14 MSTRG.7303.2_2 - 1.1e-46 159.0 0.0 1.7e-46 158.4 0.0 1.2 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family ADH_zinc_N_2 PF13602.4 MSTRG.8346.2_1 - 1.3e-20 74.6 0.0 2.2e-20 73.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.24 MSTRG.8346.2_1 - 6.8e-13 48.5 0.1 1.2e-12 47.8 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 MSTRG.8346.2_1 - 1.4e-05 24.8 0.0 2.7e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ELFV_dehydrog PF00208.19 MSTRG.8346.2_1 - 0.012 15.3 0.3 0.026 14.1 0.3 1.6 1 1 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase adh_short PF00106.23 MSTRG.8346.2_1 - 0.039 13.3 0.3 0.061 12.6 0.3 1.3 1 0 0 1 1 1 0 short chain dehydrogenase NAD4L PF06235.9 MSTRG.8346.2_3 - 0.34 10.8 4.2 0.69 9.8 4.2 1.4 1 0 0 1 1 1 0 NADH dehydrogenase subunit 4L (NAD4L) DUF1669 PF07894.10 MSTRG.110.2_3 - 2.7e-33 115.6 0.0 3.3e-33 115.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1669) Integrin_beta PF00362.16 MSTRG.8543.1_2 - 2.2e-114 381.1 0.0 2.9e-114 380.8 0.0 1.1 1 0 0 1 1 1 1 Integrin beta chain VWA domain PSI_integrin PF17205.1 MSTRG.8543.1_2 - 9.5e-12 44.4 8.2 9.5e-12 44.4 8.2 2.5 3 0 0 3 3 3 1 Integrin plexin domain Gal_Lectin PF02140.16 MSTRG.3166.2_1 - 1.7e-35 121.2 13.8 3e-20 72.3 2.9 2.4 2 0 0 2 2 2 2 Galactose binding lectin domain DUF4191 PF13829.4 MSTRG.3166.2_1 - 0.089 12.0 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) Sin3_corepress PF08295.10 MSTRG.3166.2_1 - 0.14 12.1 0.2 0.28 11.1 0.2 1.5 1 0 0 1 1 1 0 Sin3 family co-repressor Ig_2 PF13895.4 MSTRG.11016.1_2 - 1.4e-05 25.2 0.1 3.1e-05 24.1 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 MSTRG.11016.1_2 - 0.017 15.6 0.0 0.042 14.3 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain ig PF00047.23 MSTRG.11016.1_2 - 0.033 14.2 0.0 0.065 13.3 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain ATG_C PF09333.9 MSTRG.4705.1_2 - 7.3e-30 103.1 0.0 2e-29 101.6 0.0 1.7 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain ATG2_CAD PF13329.4 MSTRG.4705.1_2 - 2.2e-10 40.3 0.1 6.3e-10 38.9 0.1 1.8 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif VPS13_C PF16909.3 MSTRG.4705.1_2 - 3.6e-05 23.4 0.0 7.5e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal Guanylate_kin PF00625.19 MSTRG.4202.1_1 - 0.0072 15.9 0.1 0.0072 15.9 0.1 1.6 2 0 0 2 2 2 1 Guanylate kinase Methyltr_RsmB-F PF01189.15 MSTRG.15573.1_2 - 1.5e-23 83.3 0.0 2.2e-23 82.9 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F MFS_1 PF07690.14 MSTRG.7218.1_3 - 1.4e-21 76.7 43.9 3e-19 69.0 27.5 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 MSTRG.7218.1_3 - 1.1e-19 70.5 15.2 1.1e-19 70.5 15.2 1.4 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1_like PF12832.5 MSTRG.7218.1_3 - 0.27 9.9 18.6 0.0078 15.0 2.7 2.4 2 1 1 3 3 3 0 MFS_1 like family DUF1056 PF06341.9 MSTRG.7218.1_3 - 0.35 11.1 3.3 0.33 11.2 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1056) zf-RING_2 PF13639.4 MSTRG.22873.4_3 - 2.3e-08 34.0 3.7 2.3e-08 34.0 3.7 4.7 4 1 0 4 4 4 1 Ring finger domain SH3_3 PF08239.9 MSTRG.22873.4_3 - 8.6e-08 32.2 0.2 4.9e-07 29.8 0.0 2.4 2 0 0 2 2 2 1 Bacterial SH3 domain ANAPC10 PF03256.14 MSTRG.22873.4_3 - 1.4e-05 24.7 0.1 3.1e-05 23.6 0.1 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) zf-rbx1 PF12678.5 MSTRG.22873.4_3 - 6.8e-05 22.9 2.7 0.00096 19.3 2.6 3.3 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.3 MSTRG.22873.4_3 - 0.0024 17.4 4.0 0.0024 17.4 4.0 3.0 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4_2 PF13923.4 MSTRG.22873.4_3 - 0.0031 17.2 0.9 0.0031 17.2 0.9 4.1 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) Filamin PF00630.17 MSTRG.22873.4_3 - 0.0097 16.6 0.2 0.23 12.1 0.0 2.8 3 0 0 3 3 3 1 Filamin/ABP280 repeat PA26 PF04636.11 MSTRG.22682.2_2 - 4.1e-209 694.8 0.4 4.8e-209 694.6 0.4 1.0 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) CMD PF02627.18 MSTRG.22682.2_2 - 0.00037 20.4 0.0 0.0011 18.8 0.0 1.8 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family DUF2749 PF10907.6 MSTRG.22682.2_2 - 0.041 13.9 0.0 0.097 12.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2749) CAAP1 PF15335.4 MSTRG.23285.1_3 - 0.076 13.4 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 Caspase activity and apoptosis inhibitor 1 Spp-24 PF07448.9 MSTRG.24090.2_2 - 0.047 13.7 0.4 0.15 12.1 0.3 1.8 2 0 0 2 2 2 0 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Sulfotransfer_3 PF13469.4 MSTRG.24090.2_3 - 1.5e-51 175.7 0.0 2.3e-51 175.1 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.25 MSTRG.24090.2_3 - 6.9e-08 32.2 0.0 4e-07 29.7 0.0 2.0 1 1 0 1 1 1 1 Sulfotransferase domain Pkinase PF00069.23 MSTRG.12232.1_3 - 4.3e-72 242.5 0.0 6e-72 242.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.12232.1_3 - 8e-39 133.3 0.0 1.3e-38 132.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.16 MSTRG.12232.1_3 - 4.5e-36 122.7 0.8 2.7e-17 62.6 0.0 2.8 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.4 MSTRG.12232.1_3 - 0.00027 20.2 0.0 0.0025 17.1 0.0 2.1 1 1 1 2 2 2 1 Kinase-like PLCC PF14466.4 MSTRG.12232.1_3 - 0.14 12.1 0.3 0.26 11.3 0.3 1.3 1 0 0 1 1 1 0 PLAT/LH2 and C2-like Ca2+-binding lipoprotein ERG4_ERG24 PF01222.15 MSTRG.16500.1_3 - 1.2e-148 495.3 6.5 1.6e-148 494.9 6.5 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family LBR_tudor PF09465.8 MSTRG.16500.1_3 - 1.7e-31 107.6 0.7 3e-31 106.9 0.7 1.4 1 0 0 1 1 1 1 Lamin-B receptor of TUDOR domain DUF1295 PF06966.10 MSTRG.16500.1_3 - 2.4e-06 27.1 0.7 7.5e-06 25.5 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) DUF1325 PF07039.9 MSTRG.16500.1_3 - 0.034 14.1 0.0 0.034 14.1 0.0 1.8 2 0 0 2 2 2 0 SGF29 tudor-like domain PEMT PF04191.11 MSTRG.16500.1_3 - 0.052 13.8 0.1 0.2 11.9 0.1 2.0 1 0 0 1 1 1 0 Phospholipid methyltransferase ICMT PF04140.12 MSTRG.16500.1_3 - 0.069 13.4 3.2 0.077 13.3 0.3 2.4 2 0 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Tti2 PF10521.7 MSTRG.16500.1_3 - 0.16 11.3 0.7 0.25 10.7 0.7 1.2 1 0 0 1 1 1 0 Tti2 family Presenilin PF01080.15 MSTRG.16500.1_3 - 0.35 9.4 2.3 0.71 8.4 2.3 1.6 1 0 0 1 1 1 0 Presenilin DUF4229 PF14012.4 MSTRG.16500.1_3 - 5.1 7.1 7.2 7.4 6.6 3.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) BORG_CEP PF14957.4 MSTRG.16500.1_3 - 6 7.9 7.7 1.8 9.6 4.5 1.6 1 1 1 2 2 2 0 Cdc42 effector MFS_1 PF07690.14 MSTRG.5906.1_1 - 7.9e-27 94.0 27.2 2.7e-15 56.0 9.7 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily PUCC PF03209.13 MSTRG.5906.1_1 - 0.017 14.0 8.2 0.028 13.3 8.2 1.3 1 0 0 1 1 1 0 PUCC protein MFS_3 PF05977.11 MSTRG.5906.1_1 - 0.075 11.3 15.7 0.0083 14.4 3.1 3.0 1 1 2 3 3 3 0 Transmembrane secretion effector Trypsin PF00089.24 MSTRG.1893.2_3 - 6.3e-60 202.6 0.4 7.1e-60 202.4 0.4 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 MSTRG.1893.2_3 - 6.5e-11 43.2 0.0 9.2e-11 42.7 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 MSTRG.1893.2_3 - 0.00058 20.1 0.0 0.0012 19.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) RTT107_BRCT_5 PF16770.3 MSTRG.1893.2_3 - 0.12 12.1 0.1 1.9 8.2 0.0 2.2 1 1 1 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain Pico_P2A PF00947.17 MSTRG.1893.2_3 - 0.61 10.0 2.9 8.5 6.3 2.4 2.6 2 1 0 2 2 2 0 Picornavirus core protein 2A STAR_dimer PF16544.3 MSTRG.806.2_2 - 8.5e-23 79.6 0.0 1.6e-22 78.7 0.0 1.4 1 0 0 1 1 1 1 Homodimerisation region of STAR domain protein Quaking_NLS PF16551.3 MSTRG.806.2_2 - 2.3e-15 55.8 6.6 4.1e-15 55.0 6.6 1.4 1 0 0 1 1 1 1 Putative nuclear localisation signal of quaking KH_1 PF00013.27 MSTRG.806.2_2 - 1.5e-05 24.6 0.0 2.6e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 KH domain ER_lumen_recept PF00810.16 MSTRG.693.3_1 - 7.2e-56 188.9 7.2 1.2e-55 188.3 7.2 1.3 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.12 MSTRG.693.3_1 - 0.068 12.8 12.7 0.074 12.7 1.5 3.4 3 2 1 4 4 4 0 PQ loop repeat TF_Otx PF03529.11 MSTRG.4691.1_1 - 1.2e-32 112.0 15.7 1.2e-32 112.0 15.7 2.9 5 0 0 5 5 5 1 Otx1 transcription factor Homeobox PF00046.27 MSTRG.4691.1_1 - 1.1e-21 76.3 2.2 2e-21 75.4 2.2 1.5 1 0 0 1 1 1 1 Homeobox domain SNARE PF05739.17 MSTRG.4691.1_1 - 0.08 12.8 1.3 0.17 11.8 1.3 1.6 1 0 0 1 1 1 0 SNARE domain EphA2_TM PF14575.4 MSTRG.4691.1_1 - 0.35 11.6 3.6 1.7 9.4 0.1 2.4 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain NUDE_C PF04880.11 MSTRG.4691.1_1 - 1.3 9.3 8.1 0.29 11.5 4.4 1.8 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region AAA_8 PF12780.5 MSTRG.24832.1_2 - 3.4e-74 249.3 0.0 5e-74 248.7 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.5 MSTRG.24832.1_2 - 2.1e-09 37.0 0.0 4e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 MT PF12777.5 MSTRG.24832.1_2 - 3.1e-09 36.2 9.4 5.1e-09 35.5 9.4 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.12 MSTRG.24832.1_2 - 0.0024 17.7 0.4 0.24 11.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) TniQ PF06527.9 MSTRG.24832.1_2 - 0.038 14.6 0.1 0.079 13.5 0.1 1.5 1 0 0 1 1 1 0 TniQ G-patch PF01585.21 MSTRG.14192.1_3 - 2.2e-19 68.9 4.5 4.6e-19 67.9 4.5 1.6 1 0 0 1 1 1 1 G-patch domain zf-RanBP PF00641.16 MSTRG.14192.1_3 - 2e-10 39.7 0.8 4.1e-10 38.7 0.8 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RRM_1 PF00076.20 MSTRG.14192.1_3 - 8.6e-10 38.2 0.0 0.0013 18.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) G-patch_2 PF12656.5 MSTRG.14192.1_3 - 4.3e-09 36.2 3.3 4.3e-09 36.2 3.3 2.5 2 0 0 2 2 2 1 G-patch domain GSIII_N PF12437.6 MSTRG.14192.1_3 - 0.014 14.9 0.2 0.03 13.9 0.2 1.5 1 0 0 1 1 1 0 Glutamine synthetase type III N terminal zf-C2HE PF16278.3 MSTRG.14192.1_3 - 0.078 13.3 0.4 1.4 9.3 0.1 2.7 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2 PF00096.24 MSTRG.14192.1_3 - 3.9 8.0 5.6 0.72 10.3 0.1 2.5 2 1 0 2 2 2 0 Zinc finger, C2H2 type Pur_DNA_glyco PF02245.14 MSTRG.29379.1_2 - 2.5e-21 75.8 0.0 3e-21 75.5 0.0 1.1 1 0 0 1 1 1 1 Methylpurine-DNA glycosylase (MPG) PX PF00787.22 MSTRG.29382.1_2 - 2.9e-10 40.0 0.3 4.4e-10 39.4 0.3 1.2 1 0 0 1 1 1 1 PX domain zf-C2H2 PF00096.24 MSTRG.23293.1_3 - 3.5e-25 86.9 40.1 5.5e-05 23.3 3.7 6.2 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.23293.1_3 - 4.1e-24 83.8 46.2 1.2e-07 31.7 0.6 7.2 8 0 0 8 8 7 5 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.23293.1_3 - 3.4e-14 52.2 41.1 0.0026 18.3 3.0 6.3 6 0 0 6 6 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.23293.1_3 - 3.9e-05 23.7 31.6 0.35 11.1 0.3 6.6 6 0 0 6 6 6 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.23293.1_3 - 0.0012 19.0 0.5 0.0012 19.0 0.5 7.0 7 0 0 7 7 7 3 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.4 MSTRG.23293.1_3 - 0.0046 16.7 12.2 0.12 12.1 0.5 4.9 5 0 0 5 5 5 1 zinc-finger of a C2HC-type zf-Di19 PF05605.10 MSTRG.23293.1_3 - 0.031 14.4 22.3 0.12 12.5 2.6 4.1 1 1 4 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.3 MSTRG.23293.1_3 - 0.061 13.0 9.4 0.79 9.4 0.2 4.0 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 MSTRG.23293.1_3 - 0.12 12.3 40.5 1.2 9.0 2.7 6.0 6 0 0 6 6 5 0 C2H2-type zinc finger zf-C2H2_2 PF12756.5 MSTRG.23293.1_3 - 1.5 9.1 27.3 3.2 8.0 0.5 4.9 1 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) C1_1 PF00130.20 MSTRG.23293.1_3 - 3.3 7.6 17.8 1.4 8.7 2.3 4.4 2 1 3 5 5 5 0 Phorbol esters/diacylglycerol binding domain (C1 domain) UPF0240 PF06784.9 MSTRG.2780.1_3 - 2e-52 177.6 0.2 2.4e-52 177.3 0.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0240) HLH PF00010.24 MSTRG.5064.1_1 - 3.5e-05 23.5 3.1 6.1e-05 22.8 3.1 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain RhoGEF PF00621.18 MSTRG.13504.2_3 - 1.1e-30 107.1 3.0 2.1e-30 106.2 3.0 1.5 1 0 0 1 1 1 1 RhoGEF domain PH_13 PF16652.3 MSTRG.13504.2_3 - 1.2e-06 28.3 0.6 7.2e-06 25.8 0.6 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 MSTRG.13504.2_3 - 1.4e-05 25.4 0.1 3.9e-05 24.0 0.0 1.7 2 0 0 2 2 2 1 PH domain SUZ PF12752.5 MSTRG.13941.1_3 - 1.1e-14 54.8 2.3 1.1e-14 54.8 2.3 1.8 2 0 0 2 2 2 1 SUZ domain SUZ-C PF12901.5 MSTRG.13941.1_3 - 0.0029 17.5 0.3 0.0078 16.1 0.3 1.7 1 0 0 1 1 1 1 SUZ-C motif HECT PF00632.23 MSTRG.24614.1_2 - 6e-62 209.7 0.0 9.9e-62 209.0 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) E3_UbLigase_EDD PF11547.6 MSTRG.24614.1_2 - 7.8e-31 105.4 4.1 1.8e-30 104.3 4.1 1.6 1 0 0 1 1 1 1 E3 ubiquitin ligase EDD PABP PF00658.16 MSTRG.24614.1_2 - 3.8e-20 71.7 0.0 8.2e-20 70.7 0.0 1.5 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain CLLAC PF15675.3 MSTRG.18559.1_2 - 0.00095 18.5 0.7 0.00095 18.5 0.7 2.0 2 0 0 2 2 2 1 CLLAC-motif containing domain RasGEF PF00617.17 MSTRG.18559.1_3 - 1.5e-18 67.5 0.1 2e-18 67.0 0.1 1.2 1 0 0 1 1 1 1 RasGEF domain LRR_6 PF13516.4 MSTRG.6731.1_3 - 1.1e-11 43.7 27.5 0.0002 21.0 0.1 11.4 11 0 0 11 11 11 4 Leucine Rich repeat LRR_4 PF12799.5 MSTRG.6731.1_3 - 4.5e-09 36.3 27.1 0.094 13.0 0.1 7.7 5 3 3 8 8 8 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 MSTRG.6731.1_3 - 8.7e-05 22.3 19.6 24 5.8 0.0 9.9 9 1 0 9 9 9 3 Leucine Rich Repeat LRR_8 PF13855.4 MSTRG.6731.1_3 - 0.12 12.1 24.2 6.5 6.5 0.1 7.6 5 3 2 8 8 8 0 Leucine rich repeat Tweety PF04906.11 MSTRG.27354.2_3 - 1.7e-162 540.6 11.9 2.5e-162 540.0 11.9 1.1 1 0 0 1 1 1 1 Tweety Prominin PF05478.9 MSTRG.27354.2_3 - 0.0052 14.7 6.2 0.0093 13.8 0.6 2.6 2 1 1 3 3 3 2 Prominin DUF1345 PF07077.9 MSTRG.27354.2_3 - 0.041 13.4 2.1 3.7 7.1 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1345) GAS PF13851.4 MSTRG.27354.2_3 - 0.12 11.6 0.2 0.58 9.4 0.0 1.9 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding CUE PF02845.14 MSTRG.16481.1_2 - 2e-09 36.8 0.1 3.8e-09 35.9 0.1 1.5 1 0 0 1 1 1 1 CUE domain zf-RanBP PF00641.16 MSTRG.16481.1_2 - 0.00066 18.8 1.6 0.0028 16.8 1.6 2.1 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others DASH_Spc34 PF08657.8 MSTRG.16481.1_2 - 0.62 9.7 3.2 1 9.0 3.2 1.2 1 0 0 1 1 1 0 DASH complex subunit Spc34 DNA_binding_1 PF01035.18 MSTRG.29588.1_2 - 0.016 15.2 0.8 0.024 14.6 0.8 1.3 1 0 0 1 1 1 0 6-O-methylguanine DNA methyltransferase, DNA binding domain FAM177 PF14774.4 MSTRG.11150.1_3 - 1.1e-46 157.8 0.9 1.8e-46 157.1 0.9 1.4 1 0 0 1 1 1 1 FAM177 family DUF3824 PF12868.5 MSTRG.11150.1_3 - 0.015 15.8 2.9 0.026 15.1 2.9 1.3 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) RWD PF05773.20 MSTRG.22462.1_3 - 1.5e-14 54.2 0.0 2.7e-14 53.3 0.0 1.5 1 0 0 1 1 1 1 RWD domain DUF1115 PF06544.10 MSTRG.22462.1_3 - 2.2e-14 53.7 0.0 5.6e-14 52.3 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1115) EGF_CA PF07645.13 MSTRG.9385.2_1 - 6.6e-90 295.0 217.8 1.6e-08 34.5 5.8 16.9 16 0 0 16 16 16 13 Calcium-binding EGF domain cEGF PF12662.5 MSTRG.9385.2_1 - 1.1e-43 146.6 144.3 2.1e-07 30.6 2.3 18.4 19 0 0 19 19 19 13 Complement Clr-like EGF-like TB PF00683.15 MSTRG.9385.2_1 - 1.3e-39 133.4 67.1 3.1e-15 55.5 5.9 6.4 7 0 0 7 7 7 4 TB domain EGF PF00008.25 MSTRG.9385.2_1 - 6e-27 93.5 229.1 0.00031 20.8 6.0 17.5 17 0 0 17 17 17 14 EGF-like domain hEGF PF12661.5 MSTRG.9385.2_1 - 6.2e-19 67.8 220.2 0.015 15.8 10.1 18.1 17 0 0 17 17 17 12 Human growth factor-like EGF EGF_3 PF12947.5 MSTRG.9385.2_1 - 2.3e-15 56.3 159.2 0.0012 18.9 0.9 17.3 15 2 0 15 15 15 12 EGF domain FXa_inhibition PF14670.4 MSTRG.9385.2_1 - 3e-05 24.1 7.6 3e-05 24.1 7.6 18.7 18 2 2 20 20 20 9 Coagulation Factor Xa inhibitory site Plasmod_Pvs28 PF06247.9 MSTRG.9385.2_1 - 0.057 13.6 157.5 0.28 11.4 3.2 14.9 14 1 0 14 14 14 0 Pvs28 EGF domain Pkinase PF00069.23 MSTRG.24539.1_3 - 3.2e-72 242.9 0.0 3.9e-72 242.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.24539.1_3 - 4.2e-32 111.3 0.0 5.2e-32 111.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 MSTRG.24539.1_3 - 7.5e-05 22.0 0.0 0.00012 21.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 MSTRG.24539.1_3 - 0.00021 20.6 0.0 0.0011 18.2 0.0 1.9 2 0 0 2 2 2 1 Kinase-like APH PF01636.21 MSTRG.24539.1_3 - 0.028 14.2 0.0 4.7 6.9 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family SH2 PF00017.22 MSTRG.22324.1_1 - 1.2e-21 76.4 0.0 2.2e-21 75.6 0.0 1.4 1 0 0 1 1 1 1 SH2 domain SH2_2 PF14633.4 MSTRG.22324.1_1 - 0.0016 17.7 0.0 0.013 14.8 0.0 1.9 1 1 0 1 1 1 1 SH2 domain Rogdi_lz PF10259.7 MSTRG.2159.3_2 - 1e-48 166.0 2.8 1.3e-48 165.7 2.8 1.1 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein Vinculin PF01044.17 MSTRG.2159.3_2 - 0.39 8.7 2.8 0.54 8.3 2.8 1.0 1 0 0 1 1 1 0 Vinculin family zf-RanBP PF00641.16 MSTRG.20285.2_2 - 3.6e-08 32.4 4.9 1e-07 31.0 4.9 1.9 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others PV-1 PF06637.9 MSTRG.10657.1_3 - 2.7e-09 36.2 26.5 5e-08 32.0 26.5 2.9 1 1 0 1 1 1 1 PV-1 protein (PLVAP) Baculo_PEP_C PF04513.10 MSTRG.10657.1_3 - 0.11 12.4 13.9 0.46 10.4 0.6 3.3 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus FlaC_arch PF05377.9 MSTRG.10657.1_3 - 0.46 10.8 6.2 40 4.6 0.0 4.5 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) Herpes_BLRF2 PF05812.10 MSTRG.10657.1_3 - 2 8.5 11.0 0.36 10.8 2.8 3.3 3 1 0 3 3 3 0 Herpesvirus BLRF2 protein DUF1664 PF07889.10 MSTRG.10657.1_3 - 4.7 7.1 13.2 1.8 8.4 0.2 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Band_7 PF01145.23 MSTRG.7642.1_1 - 0.0012 18.7 0.0 0.0017 18.2 0.0 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7 PF01145.23 MSTRG.7642.1_3 - 2.9e-06 27.3 0.4 2.9e-06 27.3 0.4 1.5 1 1 1 2 2 2 1 SPFH domain / Band 7 family DUF4346 PF14251.4 MSTRG.7642.1_3 - 0.06 13.3 2.5 0.1 12.5 2.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4346) Ribosomal_L15e PF00827.15 MSTRG.25212.1_3 - 8e-96 319.1 3.7 9.4e-96 318.9 3.7 1.0 1 0 0 1 1 1 1 Ribosomal L15 TUG-UBL1 PF11470.6 MSTRG.19089.1_2 - 9.8e-27 92.9 0.4 2.3e-26 91.7 0.4 1.7 1 0 0 1 1 1 1 TUG ubiquitin-like domain UBX PF00789.18 MSTRG.19089.1_2 - 8e-10 38.7 0.0 8.8e-05 22.5 0.0 3.5 3 0 0 3 3 3 2 UBX domain RBD PF02196.13 MSTRG.19089.1_2 - 2.1e-06 27.6 0.1 6.3e-06 26.1 0.1 1.8 1 0 0 1 1 1 1 Raf-like Ras-binding domain Rad60-SLD PF11976.6 MSTRG.19089.1_2 - 0.0042 16.8 0.0 0.0088 15.7 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.21 MSTRG.19089.1_2 - 0.054 13.1 0.0 0.14 11.8 0.0 1.8 1 0 0 1 1 1 0 Ubiquitin family Ta0938 PF11494.6 MSTRG.13157.1_1 - 0.12 12.5 0.6 0.17 12.0 0.7 1.4 1 1 0 1 1 1 0 Ta0938 SF1-HH PF16275.3 MSTRG.25898.5_1 - 4.6e-23 81.6 1.4 4.6e-23 81.6 1.4 2.0 2 0 0 2 2 2 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.27 MSTRG.25898.5_1 - 1.8e-06 27.5 0.3 3.9e-06 26.5 0.3 1.6 1 0 0 1 1 1 1 KH domain zf-CCHC PF00098.21 MSTRG.25898.5_1 - 0.0006 19.6 1.2 0.0006 19.6 1.2 2.1 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_3 PF13917.4 MSTRG.25898.5_1 - 0.044 13.6 0.4 0.093 12.6 0.4 1.5 1 0 0 1 1 1 0 Zinc knuckle SF1-HH PF16275.3 MSTRG.25898.5_2 - 0.0011 19.1 0.0 0.0022 18.2 0.0 1.4 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain Ig_3 PF13927.4 MSTRG.10290.1_2 - 0.00015 22.1 0.8 0.0045 17.4 0.2 2.5 2 1 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 MSTRG.10290.1_2 - 0.0002 21.2 0.2 0.39 10.7 0.0 2.3 1 1 1 2 2 2 2 Immunoglobulin I-set domain C2-set_2 PF08205.10 MSTRG.10290.1_2 - 0.013 15.4 0.2 0.032 14.2 0.1 1.6 1 1 0 1 1 1 0 CD80-like C2-set immunoglobulin domain SAM_1 PF00536.28 MSTRG.20505.1_1 - 2.6e-12 46.8 0.0 4.1e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PHC2_SAM_assoc PF16616.3 MSTRG.20505.1_1 - 2.5e-08 34.6 1.4 4.1e-08 33.9 1.4 1.3 1 0 0 1 1 1 1 Unstructured region on Polyhomeotic-like protein 1 and 2 SAM_2 PF07647.15 MSTRG.20505.1_1 - 5.7e-06 26.2 0.0 9.3e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 MSTRG.20505.1_1 - 0.14 12.0 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain E3_UbLigase_R4 PF13764.4 MSTRG.6299.1_2 - 1.8e-45 155.3 1.0 2e-45 155.2 1.0 1.0 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase UBR4 DUF89 PF01937.17 MSTRG.22662.2_1 - 1.1e-123 412.6 0.0 1.3e-123 412.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 DZF PF07528.12 MSTRG.21763.1_2 - 6.8e-95 317.3 0.0 9e-95 316.9 0.0 1.2 1 0 0 1 1 1 1 DZF domain dsrm PF00035.24 MSTRG.21763.1_2 - 1.5e-24 86.4 0.1 6.4e-13 49.0 0.0 2.8 2 0 0 2 2 2 2 Double-stranded RNA binding motif DND1_DSRM PF14709.5 MSTRG.21763.1_2 - 0.0057 16.8 0.1 1.2 9.3 0.1 3.0 2 1 0 2 2 2 1 double strand RNA binding domain from DEAD END PROTEIN 1 SplA PF11132.6 MSTRG.21763.1_2 - 0.052 13.3 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator protein (SplA) Ten_N PF06484.10 MSTRG.17825.1_2 - 4.2e-32 112.3 0.2 5.7e-32 111.9 0.2 1.2 1 0 0 1 1 1 1 Teneurin Intracellular Region EPTP PF03736.15 MSTRG.15429.2_3 - 3.3e-71 234.9 15.2 1.3e-11 44.2 0.0 7.6 8 0 0 8 8 8 7 EPTP domain LRR_8 PF13855.4 MSTRG.15429.2_3 - 5.5e-23 80.4 3.1 7.1e-16 57.6 0.5 2.9 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.5 MSTRG.15429.2_3 - 3.8e-09 36.5 6.4 1.5e-05 25.1 0.2 2.8 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 MSTRG.15429.2_3 - 5.7e-05 23.0 0.0 0.00015 21.6 0.0 1.7 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRRCT PF01463.22 MSTRG.15429.2_3 - 0.011 16.0 0.2 0.054 13.9 0.1 2.3 2 0 0 2 2 2 0 Leucine rich repeat C-terminal domain LRR_1 PF00560.31 MSTRG.15429.2_3 - 0.015 15.5 1.0 26 5.7 0.0 4.3 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_9 PF14580.4 MSTRG.15429.2_3 - 0.13 11.6 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Leucine-rich repeat LRRNT PF01462.16 MSTRG.15429.2_3 - 2.1 8.0 4.6 3 7.5 2.8 2.3 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain Coilin_N PF15862.3 MSTRG.24165.1_1 - 2.3e-30 105.0 8.8 2.3e-30 105.0 8.8 4.1 3 1 0 3 3 3 1 Coilin N-terminus EF_assoc_2 PF08356.10 MSTRG.27849.4_2 - 1.9e-36 123.8 0.0 4.4e-36 122.6 0.0 1.7 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.10 MSTRG.27849.4_2 - 4.9e-28 96.4 1.7 2.5e-27 94.2 1.0 2.2 2 0 0 2 2 2 1 EF hand associated Ras PF00071.20 MSTRG.27849.4_2 - 1.6e-24 86.2 0.0 2.8e-18 65.9 0.0 2.4 2 0 0 2 2 2 2 Ras family Roc PF08477.11 MSTRG.27849.4_2 - 1.7e-09 37.8 0.5 1.2e-07 31.8 0.0 3.3 3 1 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 MSTRG.27849.4_2 - 2.9e-08 33.2 0.1 5.4e-08 32.3 0.1 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit EF-hand_1 PF00036.30 MSTRG.27849.4_2 - 1.9e-05 23.7 1.8 0.052 13.0 0.1 2.6 2 0 0 2 2 2 2 EF hand DUF258 PF03193.14 MSTRG.27849.4_2 - 1.9e-05 24.5 0.3 0.37 10.6 0.1 3.6 3 0 0 3 3 3 1 Protein of unknown function, DUF258 Arf PF00025.19 MSTRG.27849.4_2 - 2e-05 24.0 0.0 4.7e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 MSTRG.27849.4_2 - 8.2e-05 22.5 0.0 0.013 15.4 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase EF-hand_7 PF13499.4 MSTRG.27849.4_2 - 9.3e-05 22.7 0.1 0.62 10.5 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair Dynamin_N PF00350.21 MSTRG.27849.4_2 - 0.00025 21.0 0.1 0.11 12.4 0.1 2.4 2 0 0 2 2 2 1 Dynamin family EF-hand_6 PF13405.4 MSTRG.27849.4_2 - 0.00033 20.2 3.9 0.0052 16.5 0.4 2.7 2 0 0 2 2 2 1 EF-hand domain PduV-EutP PF10662.7 MSTRG.27849.4_2 - 0.0023 17.5 0.2 2.3 7.8 0.0 3.2 3 1 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.4 MSTRG.27849.4_2 - 0.012 15.8 0.0 4.9 7.3 0.0 2.7 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.25 MSTRG.27849.4_2 - 0.016 15.6 0.0 6 7.2 0.0 2.3 2 0 0 2 2 2 0 ABC transporter EF-hand_8 PF13833.4 MSTRG.27849.4_2 - 0.024 14.3 0.4 1.4 8.6 0.0 2.8 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.27849.4_2 - 0.036 13.5 2.3 3 7.4 0.0 2.6 2 0 0 2 2 2 0 EF hand MCM PF00493.21 MSTRG.27849.4_2 - 0.043 12.8 0.0 1.3 7.9 0.0 2.2 2 0 0 2 2 2 0 MCM2/3/5 family Septin PF00735.16 MSTRG.27849.4_2 - 0.053 12.6 0.0 7.4 5.6 0.0 2.2 2 0 0 2 2 2 0 Septin AAA_25 PF13481.4 MSTRG.27849.4_2 - 0.092 12.2 0.0 0.24 10.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA PF00004.27 MSTRG.27849.4_2 - 0.095 13.0 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.20 MSTRG.27849.4_2 - 0.11 12.8 0.0 21 5.4 0.0 2.8 3 0 0 3 3 2 0 RNA helicase FeoB_N PF02421.16 MSTRG.27849.4_2 - 0.14 11.5 0.3 0.92 8.9 0.3 2.2 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_29 PF13555.4 MSTRG.27849.4_2 - 0.16 11.6 0.1 3.3 7.4 0.0 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain Myosin_head PF00063.19 MSTRG.19594.1_1 - 7.3e-276 916.6 0.8 8.4e-276 916.4 0.8 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_N PF02736.17 MSTRG.19594.1_1 - 0.0014 18.3 0.1 0.0038 16.9 0.0 1.8 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain AAA_22 PF13401.4 MSTRG.19594.1_1 - 0.006 16.7 0.0 0.016 15.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 MSTRG.19594.1_1 - 0.018 15.3 0.0 0.042 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_10 PF12846.5 MSTRG.19594.1_1 - 0.12 11.1 0.0 0.24 10.2 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain T2SSE PF00437.18 MSTRG.19594.1_1 - 0.14 11.1 0.0 0.24 10.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Hist_deacetyl PF00850.17 MSTRG.3233.2_1 - 3.2e-83 279.6 0.0 1.3e-82 277.6 0.0 1.9 2 0 0 2 2 2 1 Histone deacetylase domain AAA PF00004.27 MSTRG.27730.1_2 - 5.5e-14 52.6 0.6 2.6e-13 50.4 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.12 MSTRG.27730.1_2 - 6.6e-12 45.5 0.0 1.5e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Rad17 PF03215.13 MSTRG.27730.1_2 - 8.8e-11 41.3 0.8 3.8e-05 22.7 0.0 2.8 3 0 0 3 3 3 2 Rad17 cell cycle checkpoint protein RuvB_N PF05496.10 MSTRG.27730.1_2 - 4.7e-07 29.2 0.0 8.1e-07 28.4 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.4 MSTRG.27730.1_2 - 1e-05 25.4 0.0 2.2e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 MSTRG.27730.1_2 - 2.5e-05 24.6 0.0 0.0016 18.7 0.0 2.9 1 1 1 2 2 2 1 AAA ATPase domain RFC1 PF08519.10 MSTRG.27730.1_2 - 0.00087 19.3 0.1 0.002 18.1 0.1 1.6 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain AAA_18 PF13238.4 MSTRG.27730.1_2 - 0.0023 18.3 0.3 0.011 16.1 0.0 2.4 2 0 0 2 2 1 1 AAA domain AAA_33 PF13671.4 MSTRG.27730.1_2 - 0.0028 17.7 0.3 0.013 15.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.4 MSTRG.27730.1_2 - 0.0042 17.2 0.0 0.28 11.3 0.0 2.9 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.4 MSTRG.27730.1_2 - 0.0054 16.3 0.0 0.015 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.10 MSTRG.27730.1_2 - 0.01 15.0 0.1 0.026 13.7 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin AAA_28 PF13521.4 MSTRG.27730.1_2 - 0.02 15.0 0.0 0.072 13.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain DNA_pol3_delta PF06144.11 MSTRG.27730.1_2 - 0.023 14.4 0.0 0.049 13.3 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase III, delta subunit NB-ARC PF00931.20 MSTRG.27730.1_2 - 0.035 13.0 0.0 0.079 11.8 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_3 PF07726.9 MSTRG.27730.1_2 - 0.036 13.8 0.0 0.083 12.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.25 MSTRG.27730.1_2 - 0.041 14.3 0.0 0.19 12.1 0.0 2.3 1 1 0 1 1 1 0 ABC transporter IstB_IS21 PF01695.15 MSTRG.27730.1_2 - 0.059 13.0 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Chitin_synth_1 PF01644.15 MSTRG.27730.1_2 - 0.063 13.2 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Chitin synthase T2SSE PF00437.18 MSTRG.27730.1_2 - 0.076 11.9 0.0 0.18 10.7 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein NACHT PF05729.10 MSTRG.27730.1_2 - 0.077 12.8 0.0 0.5 10.1 0.0 2.4 2 0 0 2 2 2 0 NACHT domain NTPase_1 PF03266.13 MSTRG.27730.1_2 - 0.084 12.6 0.1 0.25 11.1 0.0 1.8 1 1 1 2 2 2 0 NTPase TIP49 PF06068.11 MSTRG.27730.1_2 - 0.085 11.7 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus TsaE PF02367.15 MSTRG.27730.1_2 - 0.1 12.5 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.4 MSTRG.27730.1_2 - 0.1 12.9 1.5 0.18 12.1 0.0 2.2 2 0 0 2 2 1 0 AAA domain AAA_24 PF13479.4 MSTRG.27730.1_2 - 0.12 12.0 0.0 0.29 10.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.14 MSTRG.27730.1_2 - 0.14 11.9 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 FoP_duplication PF13865.4 MSTRG.27730.1_2 - 0.17 12.3 0.1 0.17 12.3 0.1 2.1 2 0 0 2 2 1 0 C-terminal duplication domain of Friend of PRMT1 Aldedh PF00171.20 MSTRG.29042.1_3 - 8.6e-36 123.3 0.0 9.8e-36 123.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.9 MSTRG.29042.1_3 - 0.088 12.1 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) V-set PF07686.15 MSTRG.16242.1_3 - 1.7e-21 76.3 3.1 1.5e-10 41.1 0.5 2.2 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.4 MSTRG.16242.1_3 - 2.5e-16 59.9 6.0 2.9e-07 30.9 0.2 3.4 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.23 MSTRG.16242.1_3 - 4e-16 58.8 2.4 4e-06 26.8 0.3 4.0 3 1 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 MSTRG.16242.1_3 - 5.4e-12 45.5 1.4 7.2e-06 25.9 0.1 3.2 3 1 0 3 3 3 2 Immunoglobulin I-set domain Ig_2 PF13895.4 MSTRG.16242.1_3 - 1.8e-06 28.1 6.2 0.034 14.4 0.2 4.3 2 1 1 3 3 3 2 Immunoglobulin domain Izumo-Ig PF16706.3 MSTRG.16242.1_3 - 0.00045 20.1 0.1 1.4 8.8 0.0 2.4 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain C1-set PF07654.13 MSTRG.16242.1_3 - 0.00063 20.0 0.9 0.049 14.0 0.0 3.4 4 1 0 4 4 4 1 Immunoglobulin C1-set domain C2-set_2 PF08205.10 MSTRG.16242.1_3 - 0.002 18.1 2.0 0.066 13.2 0.0 3.4 3 1 1 4 4 4 1 CD80-like C2-set immunoglobulin domain dbPDZ_assoc PF16610.3 MSTRG.16242.1_3 - 0.032 14.3 1.7 3.7 7.7 0.1 3.1 3 0 0 3 3 3 0 Unstructured region between two PDZ domains on Dlg5 TSP_C PF05735.10 MSTRG.15296.1_1 - 1e-68 231.1 2.0 1.4e-68 230.7 2.0 1.2 1 0 0 1 1 1 1 Thrombospondin C-terminal region TSP_3 PF02412.16 MSTRG.15296.1_1 - 8.8e-61 201.2 145.4 6.2e-12 44.9 13.9 10.1 7 2 2 9 9 9 9 Thrombospondin type 3 repeat TSP_1 PF00090.17 MSTRG.15296.1_1 - 1.2e-40 137.4 58.2 9e-16 57.7 10.0 4.7 5 0 0 5 5 5 3 Thrombospondin type 1 domain VWC PF00093.16 MSTRG.15296.1_1 - 2.1e-12 47.0 17.5 2.1e-12 47.0 17.5 7.0 3 2 0 3 3 3 1 von Willebrand factor type C domain EGF_3 PF12947.5 MSTRG.15296.1_1 - 2.2e-06 27.6 8.7 2.2e-06 27.6 8.7 5.9 5 0 0 5 5 5 1 EGF domain EGF_CA PF07645.13 MSTRG.15296.1_1 - 1.2e-05 25.3 2.2 1.2e-05 25.3 2.2 6.6 6 0 0 6 6 6 3 Calcium-binding EGF domain EGF PF00008.25 MSTRG.15296.1_1 - 0.00064 19.8 9.0 0.00064 19.8 9.0 6.9 6 1 0 6 6 6 2 EGF-like domain cEGF PF12662.5 MSTRG.15296.1_1 - 0.00096 18.9 7.8 0.0088 15.8 0.3 6.2 7 0 0 7 7 7 2 Complement Clr-like EGF-like Cofilin_ADF PF00241.18 MSTRG.1318.1_1 - 1e-21 77.3 0.1 1.7e-21 76.6 0.1 1.2 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Herpes_LAMP2 PF06126.9 MSTRG.1318.1_1 - 0.078 11.5 0.1 0.11 11.0 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus Latent membrane protein 2 DCAF15_WD40 PF14939.4 MSTRG.1318.1_1 - 0.18 11.4 0.0 1.3 8.5 0.0 2.0 2 0 0 2 2 2 0 DDB1-and CUL4-substrate receptor 15, WD repeat EF_TS PF00889.17 MSTRG.14077.1_1 - 1.9e-33 115.7 0.0 3.6e-27 95.2 0.0 2.2 1 1 1 2 2 2 2 Elongation factor TS DUF4600 PF15372.4 MSTRG.7208.2_3 - 6.4e-45 152.6 7.0 6.4e-45 152.6 7.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4600) Spc7 PF08317.9 MSTRG.7208.2_3 - 0.0028 16.4 10.2 0.0047 15.7 10.2 1.4 1 0 0 1 1 1 1 Spc7 kinetochore protein IFT57 PF10498.7 MSTRG.7208.2_3 - 0.13 11.1 6.3 0.33 9.8 6.3 1.6 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 Reo_sigmaC PF04582.10 MSTRG.7208.2_3 - 0.2 10.9 0.5 0.42 9.8 0.3 1.5 1 1 0 1 1 1 0 Reovirus sigma C capsid protein SKA1 PF07160.10 MSTRG.7208.2_3 - 0.25 11.0 10.5 0.034 13.8 2.8 2.1 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 ZapB PF06005.10 MSTRG.7208.2_3 - 0.26 11.6 15.3 0.21 11.9 8.5 2.6 2 1 0 2 2 2 0 Cell division protein ZapB KASH_CCD PF14662.4 MSTRG.7208.2_3 - 0.28 10.9 10.8 0.56 9.9 10.8 1.5 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH PRKG1_interact PF15898.3 MSTRG.7208.2_3 - 0.48 11.2 18.1 0.64 10.8 3.8 3.1 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain Mnd1 PF03962.13 MSTRG.7208.2_3 - 0.6 9.8 13.6 1.6 8.4 3.2 2.2 1 1 1 2 2 2 0 Mnd1 family DUF1664 PF07889.10 MSTRG.7208.2_3 - 0.67 9.8 5.9 0.87 9.5 1.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) PspA_IM30 PF04012.10 MSTRG.7208.2_3 - 0.9 8.9 13.5 0.39 10.1 3.8 2.1 2 0 0 2 2 2 0 PspA/IM30 family ADIP PF11559.6 MSTRG.7208.2_3 - 0.91 9.5 14.5 0.16 11.9 3.4 2.7 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Fez1 PF06818.13 MSTRG.7208.2_3 - 2.1 8.6 15.2 5.2 7.3 14.0 1.9 1 1 0 1 1 1 0 Fez1 HAUS-augmin3 PF14932.4 MSTRG.7208.2_3 - 2.3 7.5 14.3 0.6 9.4 4.2 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 Helo_like_N PF17111.3 MSTRG.7208.2_3 - 2.4 7.3 7.2 4.7 6.4 2.0 2.4 1 1 2 3 3 3 0 Fungal N-terminal domain of STAND proteins TPR_MLP1_2 PF07926.10 MSTRG.7208.2_3 - 5.1 7.0 14.0 28 4.7 2.7 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Syntaxin-6_N PF09177.9 MSTRG.7208.2_3 - 7.3 7.1 8.1 3.7e+02 1.6 8.1 2.4 1 1 0 1 1 1 0 Syntaxin 6, N-terminal IncA PF04156.12 MSTRG.7208.2_3 - 9.5 5.8 18.9 8.9 5.9 7.1 2.3 1 1 1 2 2 2 0 IncA protein zf-C4 PF00105.16 MSTRG.14159.1_2 - 7.5e-31 106.3 18.5 1.7e-30 105.1 18.5 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 MSTRG.14159.1_2 - 7.6e-31 107.2 0.2 1.1e-30 106.6 0.2 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor V-set PF07686.15 MSTRG.16953.1_1 - 2.1e-10 40.6 0.1 4.4e-10 39.6 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 MSTRG.16953.1_1 - 1.4e-08 34.7 0.1 5.6e-08 32.7 0.1 2.0 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 MSTRG.16953.1_1 - 8.2e-06 25.7 0.0 1.8e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 MSTRG.16953.1_1 - 8.8e-06 26.1 0.1 1.8e-05 25.1 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 MSTRG.16953.1_1 - 0.00026 21.1 0.2 0.0012 19.0 0.2 2.0 1 1 0 1 1 1 1 Immunoglobulin domain Syndecan PF01034.18 MSTRG.16953.1_1 - 3.9 7.3 9.2 43 4.0 4.6 3.0 3 0 0 3 3 3 0 Syndecan domain EF_assoc_2 PF08356.10 MSTRG.27849.5_2 - 1.9e-36 123.8 0.0 4.4e-36 122.6 0.0 1.7 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.10 MSTRG.27849.5_2 - 4.9e-28 96.4 1.7 2.5e-27 94.2 1.0 2.2 2 0 0 2 2 2 1 EF hand associated Ras PF00071.20 MSTRG.27849.5_2 - 1.6e-24 86.2 0.0 2.8e-18 65.9 0.0 2.4 2 0 0 2 2 2 2 Ras family Roc PF08477.11 MSTRG.27849.5_2 - 1.7e-09 37.8 0.5 1.2e-07 31.8 0.0 3.3 3 1 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 MSTRG.27849.5_2 - 2.9e-08 33.2 0.1 5.4e-08 32.3 0.1 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit EF-hand_1 PF00036.30 MSTRG.27849.5_2 - 1.9e-05 23.7 1.8 0.052 13.0 0.1 2.6 2 0 0 2 2 2 2 EF hand DUF258 PF03193.14 MSTRG.27849.5_2 - 1.9e-05 24.5 0.3 0.37 10.6 0.1 3.6 3 0 0 3 3 3 1 Protein of unknown function, DUF258 Arf PF00025.19 MSTRG.27849.5_2 - 2e-05 24.0 0.0 4.7e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 MSTRG.27849.5_2 - 8.2e-05 22.5 0.0 0.013 15.4 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase EF-hand_7 PF13499.4 MSTRG.27849.5_2 - 9.3e-05 22.7 0.1 0.62 10.5 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair Dynamin_N PF00350.21 MSTRG.27849.5_2 - 0.00025 21.0 0.1 0.11 12.4 0.1 2.4 2 0 0 2 2 2 1 Dynamin family EF-hand_6 PF13405.4 MSTRG.27849.5_2 - 0.00033 20.2 3.9 0.0052 16.5 0.4 2.7 2 0 0 2 2 2 1 EF-hand domain PduV-EutP PF10662.7 MSTRG.27849.5_2 - 0.0023 17.5 0.2 2.3 7.8 0.0 3.2 3 1 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.4 MSTRG.27849.5_2 - 0.012 15.8 0.0 4.9 7.3 0.0 2.7 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.25 MSTRG.27849.5_2 - 0.016 15.6 0.0 6 7.2 0.0 2.3 2 0 0 2 2 2 0 ABC transporter EF-hand_8 PF13833.4 MSTRG.27849.5_2 - 0.024 14.3 0.4 1.4 8.6 0.0 2.8 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.27849.5_2 - 0.036 13.5 2.3 3 7.4 0.0 2.6 2 0 0 2 2 2 0 EF hand MCM PF00493.21 MSTRG.27849.5_2 - 0.043 12.8 0.0 1.3 7.9 0.0 2.2 2 0 0 2 2 2 0 MCM2/3/5 family Septin PF00735.16 MSTRG.27849.5_2 - 0.053 12.6 0.0 7.4 5.6 0.0 2.2 2 0 0 2 2 2 0 Septin AAA_25 PF13481.4 MSTRG.27849.5_2 - 0.092 12.2 0.0 0.24 10.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA PF00004.27 MSTRG.27849.5_2 - 0.095 13.0 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.20 MSTRG.27849.5_2 - 0.11 12.8 0.0 21 5.4 0.0 2.8 3 0 0 3 3 2 0 RNA helicase FeoB_N PF02421.16 MSTRG.27849.5_2 - 0.14 11.5 0.3 0.92 8.9 0.3 2.2 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_29 PF13555.4 MSTRG.27849.5_2 - 0.16 11.6 0.1 3.3 7.4 0.0 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain CAP_GLY PF01302.23 MSTRG.20890.1_3 - 1.9e-45 152.6 6.4 1.1e-22 79.7 0.3 2.4 2 0 0 2 2 2 2 CAP-Gly domain HOOK PF05622.10 MSTRG.20890.1_3 - 1.4 6.8 31.1 3.5 5.5 31.1 1.6 1 1 0 1 1 1 0 HOOK protein DUF4482 PF14818.4 MSTRG.20890.1_3 - 6.5 7.5 18.4 2.5 8.8 10.7 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4482) Golgin_A5 PF09787.7 MSTRG.20890.1_3 - 7.7 5.7 31.1 2.6 7.3 12.0 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 CALCOCO1 PF07888.9 MSTRG.20890.1_3 - 8.5 4.7 28.9 12 4.2 28.9 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Ysc84 PF04366.10 MSTRG.26776.2_2 - 3.3e-40 136.6 0.0 4.8e-40 136.1 0.0 1.2 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.26 MSTRG.26776.2_2 - 1.7e-13 49.8 0.0 3e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.26776.2_2 - 2.5e-13 49.5 0.0 5e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.26776.2_2 - 6e-09 35.3 0.0 1.1e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Ldl_recept_a PF00057.16 MSTRG.140.1_1 - 1.1e-50 169.4 84.7 6.4e-13 48.6 12.5 5.6 5 0 0 5 5 5 5 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.15 MSTRG.140.1_1 - 4.7e-26 90.9 4.6 8.3e-10 38.9 0.2 4.3 4 0 0 4 4 4 4 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 MSTRG.140.1_1 - 1.9e-06 27.9 8.6 1.9e-06 27.9 8.6 4.5 3 3 3 6 6 6 1 Coagulation Factor Xa inhibitory site DUF5050 PF16472.3 MSTRG.140.1_1 - 0.0013 17.9 0.1 0.0021 17.2 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5050) SGL PF08450.10 MSTRG.140.1_1 - 0.019 14.4 1.9 0.06 12.8 0.6 2.3 1 1 1 2 2 2 0 SMP-30/Gluconolaconase/LRE-like region Mss4 PF04421.11 MSTRG.14145.1_3 - 5.2e-34 116.2 0.0 7.8e-34 115.6 0.0 1.3 1 0 0 1 1 1 1 Mss4 protein Oxysterol_BP PF01237.16 MSTRG.26057.2_2 - 6.4e-126 420.0 3.1 1.2e-125 419.1 3.1 1.5 1 1 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.4 MSTRG.26057.2_2 - 8.5e-14 51.5 0.4 2.2e-13 50.2 0.4 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 MSTRG.26057.2_2 - 1e-05 25.9 0.2 3.7e-05 24.1 0.2 2.0 1 0 0 1 1 1 1 PH domain TLD PF07534.14 MSTRG.7630.2_3 - 8.5e-37 126.3 0.1 1.4e-36 125.6 0.1 1.4 1 0 0 1 1 1 1 TLD FIBP PF05427.9 MSTRG.8020.3_1 - 2.6e-97 326.2 3.6 3.2e-97 325.9 3.6 1.1 1 0 0 1 1 1 1 Acidic fibroblast growth factor binding (FIBP) EGF_CA PF07645.13 MSTRG.8020.3_3 - 2.6e-41 139.4 97.1 1.7e-10 40.8 9.1 8.7 8 1 0 8 8 8 6 Calcium-binding EGF domain cEGF PF12662.5 MSTRG.8020.3_3 - 1e-34 117.9 38.4 1.6e-09 37.4 0.3 7.8 6 0 0 6 6 6 6 Complement Clr-like EGF-like FXa_inhibition PF14670.4 MSTRG.8020.3_3 - 2.3e-09 37.2 37.2 1.1e-05 25.4 7.6 8.5 8 1 1 9 9 9 4 Coagulation Factor Xa inhibitory site EGF_3 PF12947.5 MSTRG.8020.3_3 - 1.4e-06 28.3 72.5 0.00013 21.9 8.7 7.7 6 1 1 7 7 7 5 EGF domain EGF PF00008.25 MSTRG.8020.3_3 - 0.00069 19.7 6.9 0.00069 19.7 6.9 8.4 8 0 0 8 8 8 4 EGF-like domain hEGF PF12661.5 MSTRG.8020.3_3 - 1.8 9.2 75.6 0.031 14.8 5.2 10.2 8 0 0 8 8 8 0 Human growth factor-like EGF Nramp PF01566.16 MSTRG.14153.2_2 - 7.7e-85 284.9 4.6 1.2e-84 284.2 4.6 1.3 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein zf-C3HC4 PF00097.23 MSTRG.19346.1_3 - 8.8e-05 22.2 3.0 0.0002 21.0 3.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 MSTRG.19346.1_3 - 0.034 13.9 7.1 0.11 12.2 7.1 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 MSTRG.19346.1_3 - 0.06 13.1 7.0 0.1 12.4 7.0 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.19346.1_3 - 0.095 12.8 7.5 0.21 11.8 7.5 1.6 1 0 0 1 1 1 0 Ring finger domain Cupin_3 PF05899.10 MSTRG.19346.1_3 - 0.11 12.0 0.1 1.2 8.7 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF861) Nuc_recep-AF1 PF11825.6 MSTRG.6200.2_3 - 2.3e-21 75.8 22.3 3.3e-21 75.3 22.3 1.2 1 0 0 1 1 1 1 Nuclear/hormone receptor activator site AF-1 CSD PF00313.20 MSTRG.11958.1_2 - 7.1e-25 86.5 1.1 1.1e-24 85.9 1.1 1.3 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.9 MSTRG.11958.1_2 - 0.022 14.3 0.0 0.048 13.2 0.0 1.5 1 0 0 1 1 1 0 Ribonuclease B OB domain Sin_N PF04801.11 MSTRG.11958.1_2 - 7.5 5.5 8.6 11 5.0 8.6 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region Pkinase PF00069.23 MSTRG.10090.1_2 - 5.9e-63 212.6 0.0 2e-62 210.8 0.0 2.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.10090.1_2 - 3.7e-43 147.6 0.0 8.3e-43 146.4 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 MSTRG.10090.1_2 - 0.054 13.3 1.7 0.088 12.6 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family PDE6_gamma PF04868.10 MSTRG.27932.1_3 - 7.9e-42 141.3 0.4 1.1e-41 140.8 0.4 1.2 1 0 0 1 1 1 1 Retinal cGMP phosphodiesterase, gamma subunit Lipoxygenase PF00305.17 MSTRG.2040.2_2 - 3.1e-62 210.8 0.1 1.2e-61 209.0 0.1 1.7 1 1 0 1 1 1 1 Lipoxygenase PLAT PF01477.21 MSTRG.2040.2_2 - 9.3e-13 48.6 0.0 1.8e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 PLAT/LH2 domain Transglut_core PF01841.17 MSTRG.19537.1_1 - 3.7e-10 40.1 0.0 3.7e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 Transglutaminase-like superfamily HEAT PF02985.20 MSTRG.7310.2_3 - 1.6e-05 24.6 0.0 0.067 13.3 0.0 2.3 2 0 0 2 2 2 2 HEAT repeat Cnd1 PF12717.5 MSTRG.7310.2_3 - 0.025 14.4 0.0 0.031 14.1 0.0 1.1 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 PDZ PF00595.22 MSTRG.15215.3_3 - 1.4e-65 217.4 5.6 1.1e-14 54.4 0.0 6.4 6 0 0 6 6 6 6 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.15215.3_3 - 1.3e-25 89.4 0.3 0.00056 20.0 0.0 6.3 6 0 0 6 6 6 5 PDZ domain MAGI_u1 PF16663.3 MSTRG.15215.3_3 - 1.6e-24 85.5 2.0 6.6e-24 83.5 2.0 2.2 1 0 0 1 1 1 1 Unstructured region on MAGI WW PF00397.24 MSTRG.15215.3_3 - 8.5e-17 60.7 3.5 7.7e-10 38.4 0.3 3.0 3 0 0 3 3 3 2 WW domain Guanylate_kin PF00625.19 MSTRG.15215.3_3 - 3.2e-10 39.8 0.0 5.8e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase Tricorn_PDZ PF14685.4 MSTRG.15215.3_3 - 1.4e-06 28.1 5.7 0.91 9.4 0.1 5.8 6 0 0 6 6 6 2 Tricorn protease PDZ domain DUF4604 PF15377.4 MSTRG.15215.3_3 - 0.011 16.1 0.7 0.011 16.1 0.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) BCL_N PF04714.11 MSTRG.20887.1_1 - 3.4e-28 97.3 7.3 7.2e-28 96.3 7.3 1.6 1 0 0 1 1 1 1 BCL7, N-terminal conserver region UPF0560 PF10577.7 MSTRG.20887.1_1 - 7.9 4.7 14.6 11 4.2 14.6 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 FYVE PF01363.19 MSTRG.8503.1_1 - 1.5e-17 63.4 7.9 1.5e-17 63.4 7.9 1.9 2 0 0 2 2 2 1 FYVE zinc finger PH PF00169.27 MSTRG.8503.1_1 - 1.5e-09 38.2 0.1 3.3e-09 37.1 0.0 1.6 2 0 0 2 2 2 1 PH domain FYVE_2 PF02318.14 MSTRG.8503.1_1 - 0.0013 18.8 4.1 0.0029 17.7 4.1 1.6 1 0 0 1 1 1 1 FYVE-type zinc finger PH_13 PF16652.3 MSTRG.8503.1_1 - 0.03 14.1 0.7 0.98 9.2 0.7 2.3 1 1 0 1 1 1 0 Pleckstrin homology domain DUF3522 PF12036.6 MSTRG.12089.2_2 - 2.5e-43 148.4 9.5 2.5e-43 148.4 9.5 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3522) DUF1461 PF07314.9 MSTRG.24253.1_1 - 0.28 10.9 0.0 0.33 10.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1461) RGS-like PF09128.9 MSTRG.23340.1_1 - 5.8e-60 202.1 2.9 1.6e-59 200.6 2.9 1.8 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain RhoGEF PF00621.18 MSTRG.23340.1_1 - 5.3e-34 117.9 5.1 5.3e-34 117.9 5.1 2.0 2 0 0 2 2 2 1 RhoGEF domain PH_13 PF16652.3 MSTRG.23340.1_1 - 0.0022 17.7 0.1 0.0046 16.7 0.1 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PEX11 PF05648.12 MSTRG.14439.5_3 - 2.7e-60 203.5 0.0 3.7e-60 203.0 0.0 1.2 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) C1q PF00386.19 MSTRG.3610.3_3 - 7.7e-31 106.8 0.4 3.5e-21 75.6 0.1 2.2 2 0 0 2 2 2 2 C1q domain TNF PF00229.16 MSTRG.3610.3_3 - 0.00022 21.0 0.3 0.73 9.7 0.0 3.0 1 1 1 2 2 2 2 TNF(Tumour Necrosis Factor) family DUF4658 PF15555.4 MSTRG.3610.3_3 - 0.026 14.4 0.7 0.066 13.1 0.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4658) YABBY PF04690.11 MSTRG.3610.3_3 - 0.046 14.1 0.0 0.078 13.4 0.0 1.3 1 0 0 1 1 1 0 YABBY protein Golgin_A5 PF09787.7 MSTRG.3610.3_3 - 0.093 12.0 0.0 0.093 12.0 0.0 1.4 2 0 0 2 2 2 0 Golgin subfamily A member 5 PPC PF04151.13 MSTRG.3610.3_3 - 0.14 13.1 0.6 0.31 12.1 0.2 1.8 2 0 0 2 2 2 0 Bacterial pre-peptidase C-terminal domain COX4_pro_2 PF07835.10 MSTRG.3610.3_3 - 9.8 6.2 6.3 28 4.8 0.0 2.7 3 0 0 3 3 3 0 Bacterial aa3 type cytochrome c oxidase subunit IV WD40 PF00400.30 MSTRG.24979.1_2 - 1.3e-27 95.4 16.0 0.00013 22.6 0.1 7.6 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.24979.1_2 - 3.4e-12 46.3 0.0 0.0014 18.7 0.0 5.3 3 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 MSTRG.24979.1_2 - 0.071 12.3 0.0 4.7 6.3 0.0 3.1 3 1 1 4 4 4 0 WD40-like domain LEAP-2 PF07359.9 MSTRG.8167.1_1 - 5.3e-14 51.7 1.0 1.1e-13 50.7 1.0 1.4 1 0 0 1 1 1 1 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) ZU5 PF00791.18 MSTRG.26447.5_2 - 0.00057 20.0 0.4 0.0017 18.5 0.1 2.0 2 0 0 2 2 2 1 ZU5 domain MAPEG PF01124.16 MSTRG.3645.1_3 - 0.4 10.4 8.0 0.8 9.5 7.7 1.6 1 1 1 2 2 2 0 MAPEG family Acyl-CoA_dh_1 PF00441.22 MSTRG.24496.1_3 - 4.8e-40 137.1 5.8 5.9e-37 127.0 2.6 2.5 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.17 MSTRG.24496.1_3 - 5.1e-25 87.4 0.0 1.2e-24 86.2 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.14 MSTRG.24496.1_3 - 1.6e-23 83.4 0.0 4.8e-23 81.8 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.9 MSTRG.24496.1_3 - 2.1e-13 50.6 7.1 5.2e-13 49.3 0.3 3.2 3 0 0 3 3 3 1 Acyl-CoA dehydrogenase, C-terminal domain Mor PF08765.9 MSTRG.24496.1_3 - 0.12 12.2 0.0 0.42 10.5 0.0 1.9 1 0 0 1 1 1 0 Mor transcription activator family SelP_N PF04592.12 MSTRG.11859.1_1 - 2.4 7.3 7.5 3.2 7.0 7.5 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Chromo PF00385.22 MSTRG.1463.4_2 - 1.3e-12 47.2 0.9 1.3e-12 47.2 0.9 2.1 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain BrkDBD PF09607.8 MSTRG.1463.4_2 - 2.7e-05 23.7 0.2 7e-05 22.4 0.2 1.7 1 0 0 1 1 1 1 Brinker DNA-binding domain HTH_Tnp_1 PF01527.18 MSTRG.1463.4_2 - 0.00034 20.7 2.7 0.00039 20.5 0.2 2.5 2 0 0 2 2 2 1 Transposase HTH_28 PF13518.4 MSTRG.1463.4_2 - 0.05 13.6 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_29 PF13551.4 MSTRG.1463.4_2 - 0.098 12.6 0.5 0.28 11.1 0.1 2.0 2 0 0 2 2 2 0 Winged helix-turn helix Arm PF00514.21 MSTRG.20261.1_1 - 8.6e-29 98.5 13.6 1.4e-09 37.5 0.0 6.7 7 0 0 7 7 7 4 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.4 MSTRG.20261.1_1 - 1.3e-06 28.6 11.5 0.018 15.4 0.1 5.8 5 1 1 6 6 6 3 HEAT-like repeat HEAT_2 PF13646.4 MSTRG.20261.1_1 - 9.3e-05 22.6 1.5 0.31 11.3 0.0 3.4 2 2 1 3 3 3 2 HEAT repeats HEAT PF02985.20 MSTRG.20261.1_1 - 0.00038 20.3 0.3 0.096 12.8 0.0 3.5 3 0 0 3 3 3 1 HEAT repeat Atx10homo_assoc PF09759.7 MSTRG.20261.1_1 - 0.014 15.4 2.0 0.031 14.2 0.0 2.4 3 0 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain Nipped-B_C PF12830.5 MSTRG.20261.1_1 - 0.014 15.2 0.0 0.049 13.4 0.0 1.9 2 0 0 2 2 2 0 Sister chromatid cohesion C-terminus V-ATPase_H_N PF03224.12 MSTRG.20261.1_1 - 0.021 14.0 2.3 0.043 13.0 0.3 2.1 2 0 0 2 2 2 0 V-ATPase subunit H Sushi PF00084.18 MSTRG.7618.1_1 - 1.8e-37 127.6 30.2 8.4e-12 45.4 0.2 5.0 5 0 0 5 5 5 4 Sushi repeat (SCR repeat) DUF843 PF05814.9 MSTRG.7618.1_1 - 0.52 10.2 3.0 0.89 9.5 3.0 1.3 1 0 0 1 1 1 0 Baculovirus protein of unknown function (DUF843) ACTH_assoc PF16102.3 MSTRG.7618.1_2 - 0.16 12.7 0.5 0.34 11.7 0.5 1.6 1 0 0 1 1 1 0 ACTH-associated domain Sushi PF00084.18 MSTRG.7618.1_3 - 5.2e-17 62.1 11.9 4.8e-10 39.8 0.2 2.5 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) Ank_2 PF12796.5 MSTRG.20327.2_1 - 4.4e-40 136.0 2.1 3.4e-12 46.7 0.0 4.1 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 MSTRG.20327.2_1 - 6.1e-35 118.6 10.4 7.3e-09 35.6 0.7 7.6 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.28 MSTRG.20327.2_1 - 2e-32 110.1 11.9 0.00016 21.8 0.0 7.1 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.4 MSTRG.20327.2_1 - 4e-32 110.0 5.5 1.1e-07 32.1 0.2 6.0 4 1 0 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.20327.2_1 - 2.5e-31 104.1 3.8 0.00027 21.0 0.0 7.5 7 0 0 7 7 7 6 Ankyrin repeat SAM_1 PF00536.28 MSTRG.20327.2_1 - 1e-26 93.0 0.1 2.3e-12 47.1 0.0 2.5 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 MSTRG.20327.2_1 - 9.5e-21 73.6 0.3 2.5e-11 43.4 0.0 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) PID PF00640.21 MSTRG.20327.2_1 - 1.6e-17 63.7 0.4 2.6e-17 63.1 0.4 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PID_2 PF14719.4 MSTRG.20327.2_1 - 0.00062 19.6 0.1 0.001 18.8 0.1 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 MSTRG.20327.2_1 - 0.0034 17.4 0.1 0.0063 16.5 0.1 1.4 1 0 0 1 1 1 1 Phosphotyrosine-binding domain SARG PF15385.4 MSTRG.20327.2_2 - 9.1e-48 163.7 21.9 6.3e-38 131.2 17.5 2.3 2 0 0 2 2 2 2 Specifically androgen-regulated gene protein Trypan_PARP PF05887.9 MSTRG.20327.2_2 - 0.16 11.9 8.2 0.33 10.8 8.2 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Lig_chan PF00060.24 MSTRG.6383.1_1 - 3.1e-20 72.4 0.0 3.3e-20 72.3 0.0 1.1 1 0 0 1 1 1 1 Ligand-gated ion channel Rib_recp_KP_reg PF05104.10 MSTRG.4684.3_3 - 0.0006 20.7 35.7 0.0006 20.7 35.7 5.3 3 1 2 5 5 5 1 Ribosome receptor lysine/proline rich region Viral_Beta_CD PF04530.10 MSTRG.4684.3_3 - 0.019 15.2 0.1 0.066 13.4 0.1 1.9 1 0 0 1 1 1 0 Viral Beta C/D like family Lip_prot_lig_C PF10437.7 MSTRG.4684.3_3 - 0.2 11.5 6.4 6.6 6.7 0.0 4.4 4 0 0 4 4 4 0 Bacterial lipoate protein ligase C-terminus DUF1180 PF06679.10 MSTRG.4684.3_3 - 0.55 10.5 0.0 0.55 10.5 0.0 4.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1180) GD_N PF16030.3 MSTRG.4684.3_3 - 1.6 8.9 5.5 0.7 10.1 0.6 3.0 2 1 1 3 3 3 0 Serine protease gd N-terminus PIN PF01850.19 MSTRG.4684.3_3 - 3.8 7.9 5.8 5.4 7.4 0.0 3.9 3 1 1 4 4 4 0 PIN domain RRM_1 PF00076.20 MSTRG.24243.1_3 - 1.6e-31 107.8 0.0 5e-15 55.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.9 MSTRG.24243.1_3 - 1.6e-06 27.9 0.0 0.036 14.0 0.0 2.8 2 2 0 2 2 2 2 RNA binding domain RRM_7 PF16367.3 MSTRG.24243.1_3 - 4.5e-05 23.3 0.0 0.1 12.6 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif PHM7_cyt PF14703.4 MSTRG.24243.1_3 - 0.002 18.2 3.3 0.5 10.4 0.3 3.2 2 2 1 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter PID PF00640.21 MSTRG.11409.2_1 - 9.3e-48 161.7 0.0 3.8e-36 124.1 0.0 2.7 3 0 0 3 3 3 2 Phosphotyrosine interaction domain (PTB/PID) WW PF00397.24 MSTRG.11409.2_1 - 1.1e-06 28.3 0.4 2.3e-06 27.3 0.4 1.6 1 0 0 1 1 1 1 WW domain PTB PF08416.11 MSTRG.11409.2_1 - 5.8e-05 23.1 0.0 0.00043 20.3 0.0 2.1 2 0 0 2 2 2 1 Phosphotyrosine-binding domain Pkinase PF00069.23 MSTRG.12437.1_1 - 7.6e-67 225.3 0.0 1.2e-66 224.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Guanylate_kin PF00625.19 MSTRG.12437.1_1 - 3.7e-59 199.3 0.2 5.6e-59 198.7 0.2 1.3 1 0 0 1 1 1 1 Guanylate kinase Pkinase_Tyr PF07714.15 MSTRG.12437.1_1 - 2.2e-29 102.4 0.0 3.4e-29 101.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase L27 PF02828.14 MSTRG.12437.1_1 - 4.2e-24 83.9 8.5 3.5e-14 52.1 0.4 3.3 3 0 0 3 3 3 2 L27 domain PDZ PF00595.22 MSTRG.12437.1_1 - 5.6e-16 58.5 0.7 1.1e-15 57.6 0.7 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) SH3_2 PF07653.15 MSTRG.12437.1_1 - 4.5e-11 42.1 0.0 9.1e-11 41.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 MSTRG.12437.1_1 - 5.2e-08 32.2 0.1 1.3e-07 31.0 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.12437.1_1 - 0.00034 20.3 0.0 0.00087 19.0 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain PDZ_2 PF13180.4 MSTRG.12437.1_1 - 0.004 17.3 0.0 0.0087 16.2 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Kinase-like PF14531.4 MSTRG.12437.1_1 - 0.0041 16.3 0.0 0.034 13.3 0.0 2.0 2 0 0 2 2 2 1 Kinase-like TFIIF_beta PF02270.13 MSTRG.16091.2_2 - 1.2e-47 163.2 1.4 3e-47 162.0 1.5 1.5 1 1 0 1 1 1 1 Transcription initiation factor IIF, beta subunit TFIIF_beta PF02270.13 MSTRG.16091.2_3 - 1.7e-06 28.3 0.1 2.5e-06 27.7 0.1 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, beta subunit DUF4569 PF15133.4 MSTRG.22370.1_1 - 1.6e-74 251.2 0.0 2e-73 247.6 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4569) PH PF00169.27 MSTRG.19513.1_2 - 1.1e-11 45.1 1.5 4.2e-07 30.3 0.0 2.9 3 0 0 3 3 3 2 PH domain PH_11 PF15413.4 MSTRG.19513.1_2 - 0.72 10.2 4.3 15 6.0 0.1 3.5 2 1 0 2 2 2 0 Pleckstrin homology domain Defensin_beta_2 PF13841.4 MSTRG.5207.1_3 - 0.011 16.0 1.8 0.011 16.0 1.8 2.7 3 1 0 3 3 3 0 Beta defensin PPARgamma_N PF12577.6 MSTRG.21045.1_3 - 1e-31 109.3 2.8 2.6e-31 107.9 2.8 1.8 1 0 0 1 1 1 1 PPAR gamma N-terminal region zf-C4 PF00105.16 MSTRG.21045.1_3 - 9e-27 93.2 15.4 9e-27 93.2 15.4 1.9 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 MSTRG.21045.1_3 - 1.7e-16 60.3 1.2 3.5e-16 59.3 1.2 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor BH3 PF15285.4 MSTRG.15465.3_3 - 3.4e-17 61.7 0.2 6.3e-17 60.8 0.2 1.5 1 0 0 1 1 1 1 Beclin-1 BH3 domain, Bcl-2-interacting APG6 PF04111.10 MSTRG.15465.3_3 - 2.4e-05 23.8 2.2 3.8e-05 23.1 2.2 1.3 1 0 0 1 1 1 1 Autophagy protein Apg6 DUF3591 PF12157.6 MSTRG.3851.2_2 - 3.4e-165 549.9 0.0 2.3e-164 547.1 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3591) TBP-binding PF09247.9 MSTRG.3851.2_2 - 2.6e-24 85.1 5.9 6.5e-24 83.8 5.9 1.7 1 0 0 1 1 1 1 TATA box-binding protein binding zf-CCHC_6 PF15288.4 MSTRG.3851.2_2 - 1.2e-15 57.0 0.3 3.3e-15 55.5 0.3 1.8 1 0 0 1 1 1 1 Zinc knuckle DAP PF15228.4 MSTRG.21865.1_2 - 3.6e-28 98.4 7.9 7e-28 97.5 7.9 1.5 1 0 0 1 1 1 1 Death-associated protein zf-HC5HC2H_2 PF13832.4 MSTRG.10558.1_3 - 8.2e-31 106.3 7.8 8.2e-31 106.3 7.8 1.5 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.4 MSTRG.10558.1_3 - 2.9e-17 62.5 6.0 5.3e-17 61.7 6.0 1.4 1 0 0 1 1 1 1 PHD-like zinc-binding domain PHD PF00628.27 MSTRG.10558.1_3 - 0.00051 19.7 5.4 0.0011 18.7 4.1 2.1 2 0 0 2 2 2 1 PHD-finger DUF4537 PF15057.4 MSTRG.10558.1_3 - 0.0013 18.6 0.2 0.029 14.2 0.0 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF4537) LBR_tudor PF09465.8 MSTRG.10558.1_3 - 0.002 17.8 0.2 1.4 8.6 0.0 2.3 2 0 0 2 2 2 2 Lamin-B receptor of TUDOR domain zf-RING-like PF08746.9 MSTRG.10558.1_3 - 0.046 13.9 2.6 0.16 12.2 2.6 1.9 1 0 0 1 1 1 0 RING-like domain FANCL_C PF11793.6 MSTRG.10558.1_3 - 2.8 8.0 9.3 1.6 8.8 6.5 2.0 2 0 0 2 2 2 0 FANCL C-terminal domain Zip PF02535.20 MSTRG.9197.1_2 - 2.3e-27 96.0 1.7 2.3e-27 96.0 1.7 3.8 3 1 0 4 4 4 3 ZIP Zinc transporter eIF-5a PF01287.18 MSTRG.2278.1_1 - 1.2e-26 92.4 0.2 1.8e-26 91.9 0.2 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.10 MSTRG.2278.1_1 - 0.056 13.4 0.6 0.12 12.2 0.0 1.8 2 0 0 2 2 2 0 Elongation factor P (EF-P) KOW-like domain Aminotran_3 PF00202.19 MSTRG.17911.2_2 - 1.2e-48 165.6 0.0 1.6e-48 165.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III LRR_8 PF13855.4 MSTRG.17641.1_1 - 1.5e-35 120.6 29.4 5.5e-08 32.3 1.7 6.8 3 1 6 9 9 9 9 Leucine rich repeat LRR_4 PF12799.5 MSTRG.17641.1_1 - 1e-25 89.1 30.0 4.4e-05 23.6 0.0 9.1 5 2 3 9 9 9 9 Leucine Rich repeats (2 copies) PDZ PF00595.22 MSTRG.17641.1_1 - 4.2e-15 55.7 0.1 1.2e-14 54.3 0.0 1.8 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) LRR_5 PF13306.4 MSTRG.17641.1_1 - 2e-05 24.4 0.3 0.05 13.4 0.1 3.3 2 1 1 3 3 3 2 Leucine rich repeats (6 copies) PDZ_2 PF13180.4 MSTRG.17641.1_1 - 5.6e-05 23.3 0.0 0.00013 22.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain RsmF_methylt_CI PF17126.3 MSTRG.17641.1_1 - 0.15 12.0 1.3 6.2 6.8 0.0 3.4 4 0 0 4 4 4 0 RsmF rRNA methyltransferase first C-terminal domain LRR_1 PF00560.31 MSTRG.17641.1_1 - 5.9 7.6 24.5 2.6 8.7 0.1 8.6 10 1 0 10 10 10 0 Leucine Rich Repeat C1-set PF07654.13 MSTRG.1025.1_1 - 7.7e-24 83.9 0.1 1.5e-23 83.0 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_II_beta PF00969.17 MSTRG.1025.1_1 - 3.9e-12 46.0 0.5 7.1e-12 45.2 0.5 1.4 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C2-set_2 PF08205.10 MSTRG.1025.1_1 - 9.6e-06 25.5 0.0 2e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 MSTRG.1025.1_1 - 0.00032 21.1 0.0 0.00097 19.6 0.0 1.8 1 1 1 2 2 2 1 Immunoglobulin domain Rab_bind PF16704.3 MSTRG.14829.3_3 - 5.9e-38 128.6 5.5 1.3e-37 127.5 5.5 1.6 1 0 0 1 1 1 1 Rab binding domain GRIP PF01465.18 MSTRG.14829.3_3 - 1e-17 63.6 0.3 1.9e-17 62.8 0.3 1.5 1 0 0 1 1 1 1 GRIP domain PAP2 PF01569.19 MSTRG.12090.1_2 - 1e-26 93.2 2.6 3.3e-26 91.6 2.6 1.9 1 0 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.4 MSTRG.12090.1_2 - 6.1e-05 23.3 4.8 0.00033 21.0 4.8 2.3 1 0 0 1 1 1 1 PAP2 superfamily C-terminal SKG6 PF08693.8 MSTRG.12090.1_2 - 0.91 8.9 5.3 2.7 7.4 5.3 1.8 1 0 0 1 1 1 0 Transmembrane alpha-helix domain MHC_I PF00129.16 MSTRG.16140.2_3 - 5.8e-17 61.7 0.1 6.6e-17 61.5 0.1 1.0 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Ribosomal_L3 PF00297.20 MSTRG.14224.1_3 - 1.1e-173 577.3 9.9 1.3e-173 577.1 9.9 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 CN_hydrolase PF00795.20 MSTRG.16563.5_3 - 0.00016 21.0 0.0 0.00021 20.6 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase G-alpha PF00503.18 MSTRG.3190.1_3 - 6.5e-121 403.7 4.9 8.3e-121 403.3 4.9 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 MSTRG.3190.1_3 - 8.2e-16 57.8 0.4 2.8e-12 46.3 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.11 MSTRG.3190.1_3 - 0.00032 20.8 0.2 0.62 10.2 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.10 MSTRG.3190.1_3 - 0.00068 18.9 2.3 0.024 13.9 0.6 2.2 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region XRCC1_N PF01834.14 MSTRG.6850.4_3 - 1.9e-69 232.3 0.4 2.8e-69 231.8 0.4 1.3 1 0 0 1 1 1 1 XRCC1 N terminal domain BRCT PF00533.24 MSTRG.6850.4_3 - 1.5e-19 70.1 0.0 5.9e-11 42.5 0.0 2.7 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.3 MSTRG.6850.4_3 - 1.3e-16 60.6 0.0 6.3e-10 39.2 0.0 2.5 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.5 MSTRG.6850.4_3 - 4.1e-11 42.5 0.0 6.2e-09 35.5 0.0 2.5 2 0 0 2 2 2 2 twin BRCT domain LIG3_BRCT PF16759.3 MSTRG.6850.4_3 - 1.6e-05 24.9 0.0 0.00031 20.8 0.0 2.5 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain FH2 PF02181.21 MSTRG.7261.1_1 - 4.5e-93 312.2 8.7 4.5e-93 312.2 8.7 1.9 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_FH3 PF06367.14 MSTRG.7261.1_1 - 2.7e-18 66.1 0.1 8.9e-18 64.5 0.0 1.9 2 0 0 2 2 2 1 Diaphanous FH3 Domain DUF2360 PF10152.7 MSTRG.7261.1_1 - 0.00091 19.5 0.9 0.004 17.4 0.0 2.5 2 1 0 2 2 2 1 Predicted coiled-coil domain-containing protein (DUF2360) CLZ PF16526.3 MSTRG.7261.1_1 - 0.032 14.5 1.0 0.46 10.7 0.3 2.7 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels OSCP PF00213.16 MSTRG.7261.1_1 - 0.089 12.8 2.4 0.1 12.5 0.4 2.0 2 0 0 2 2 2 0 ATP synthase delta (OSCP) subunit Occludin_ELL PF07303.11 MSTRG.7261.1_1 - 0.27 11.8 8.0 1.3 9.6 1.5 3.6 3 1 0 3 3 3 0 Occludin homology domain PKcGMP_CC PF16808.3 MSTRG.7261.1_1 - 0.82 9.4 8.4 0.086 12.6 3.1 2.2 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase AAA_23 PF13476.4 MSTRG.7261.1_1 - 1.7 9.0 14.2 0.25 11.7 1.8 2.4 2 0 0 2 2 2 0 AAA domain bZIP_2 PF07716.13 MSTRG.7261.1_1 - 6.6 6.8 9.6 0.31 11.0 2.1 2.8 3 0 0 3 3 3 0 Basic region leucine zipper CBS PF00571.26 MSTRG.12742.2_2 - 3.3e-25 88.2 2.2 4.2e-07 30.2 0.2 4.4 4 0 0 4 4 4 4 CBS domain RINGv PF12906.5 MSTRG.1563.2_2 - 0.0017 18.3 7.9 0.0041 17.1 4.2 2.4 2 1 0 2 2 2 2 RING-variant domain CCDC32 PF14989.4 MSTRG.17695.1_3 - 1.4e-55 187.3 0.4 2.1e-55 186.8 0.4 1.3 1 0 0 1 1 1 1 Coiled-coil domain containing 32 TIMP PF00965.15 MSTRG.1390.1_3 - 7.8e-46 156.0 6.4 9.8e-46 155.7 6.4 1.1 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.19 MSTRG.1390.1_3 - 0.0027 17.4 0.1 0.0046 16.6 0.1 1.5 1 0 0 1 1 1 1 UNC-6/NTR/C345C module PTS_2-RNA PF01885.14 MSTRG.7303.3_1 - 2.6e-48 164.3 0.0 3.8e-48 163.8 0.0 1.2 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family PX PF00787.22 MSTRG.17248.1_3 - 2e-21 75.9 0.7 3.2e-21 75.3 0.7 1.3 1 0 0 1 1 1 1 PX domain PNP_UDP_1 PF01048.18 MSTRG.24497.1_3 - 2.1e-50 171.0 0.1 2.5e-50 170.8 0.1 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily LisH PF08513.9 MSTRG.7741.1_3 - 0.024 14.5 0.1 0.054 13.4 0.1 1.6 1 0 0 1 1 1 0 LisH CSTF1_dimer PF16699.3 MSTRG.7741.1_3 - 0.071 12.8 0.5 0.35 10.5 0.0 2.0 2 0 0 2 2 2 0 Cleavage stimulation factor subunit 1, dimerisation domain MRP PF09387.8 MSTRG.20121.1_1 - 0.041 13.7 0.1 0.069 13.0 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial RNA binding protein MRP FAM184 PF15665.3 MSTRG.20121.1_2 - 3.6e-63 213.0 26.3 4.4e-63 212.7 26.3 1.1 1 0 0 1 1 1 1 Family with sequence similarity 184, A and B TMF_DNA_bd PF12329.6 MSTRG.20121.1_2 - 0.0055 16.5 2.4 0.0055 16.5 2.4 3.0 2 2 0 3 3 3 1 TATA element modulatory factor 1 DNA binding DUF148 PF02520.15 MSTRG.20121.1_2 - 0.014 15.4 11.6 0.36 10.8 1.6 2.6 2 1 0 2 2 2 0 Domain of unknown function DUF148 DUF4220 PF13968.4 MSTRG.20121.1_2 - 0.23 10.9 2.6 0.31 10.5 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) Peptidase_M2 PF01401.16 MSTRG.20121.1_2 - 0.26 9.7 15.2 1.5 7.2 13.8 1.9 1 1 1 2 2 2 0 Angiotensin-converting enzyme DUF4407 PF14362.4 MSTRG.20121.1_2 - 0.49 9.6 12.0 1.4 8.1 12.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.13 MSTRG.20121.1_2 - 8.5 5.7 14.4 12 5.2 14.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DivIC PF04977.13 MSTRG.20121.1_2 - 8.6 6.1 10.4 0.082 12.5 1.0 2.4 3 0 0 3 3 3 0 Septum formation initiator TRAP_beta PF05753.12 MSTRG.6136.1_1 - 6.8e-68 227.4 0.0 1e-67 226.9 0.0 1.1 1 0 0 1 1 1 1 Translocon-associated protein beta (TRAPB) Retrotrans_gag PF03732.15 MSTRG.14384.1_1 - 1.2e-07 31.8 0.0 1.7e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon gag protein NTP_transferase PF00483.21 MSTRG.27302.2_3 - 6.7e-11 42.1 0.0 2e-10 40.5 0.0 1.7 1 1 0 1 1 1 1 Nucleotidyl transferase GHMP_kinases_N PF00288.24 MSTRG.27302.2_3 - 1.1e-05 25.4 0.0 2.2e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain NTP_transf_3 PF12804.5 MSTRG.27302.2_3 - 0.0012 19.0 0.0 0.0021 18.3 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain Anoctamin PF04547.10 MSTRG.25047.1_3 - 8.4e-152 505.8 21.7 1.2e-113 380.0 8.9 2.2 2 0 0 2 2 2 2 Calcium-activated chloride channel Anoct_dimer PF16178.3 MSTRG.25047.1_3 - 1.4e-67 227.6 0.2 2.1e-67 227.1 0.2 1.2 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin A2M_N_2 PF07703.12 MSTRG.16793.1_2 - 1.9e-26 92.9 0.1 1.6e-24 86.7 0.0 3.6 3 1 0 3 3 3 1 Alpha-2-macroglobulin family N-terminal region A2M PF00207.20 MSTRG.16793.1_2 - 4.4e-20 71.2 0.5 2.4e-19 68.8 0.0 2.4 2 0 0 2 2 2 1 Alpha-2-macroglobulin family A2M_N PF01835.17 MSTRG.16793.1_2 - 2.1e-16 60.0 0.0 8.2e-16 58.1 0.0 2.1 1 0 0 1 1 1 1 MG2 domain A2M_comp PF07678.12 MSTRG.16793.1_2 - 2.1e-15 56.8 0.2 3.3e-15 56.1 0.2 1.3 1 0 0 1 1 1 1 A-macroglobulin complement component ANATO PF01821.16 MSTRG.16793.1_2 - 8.5e-05 23.2 7.5 0.0002 22.0 7.5 1.7 1 0 0 1 1 1 1 Anaphylotoxin-like domain BCNT PF07572.10 MSTRG.12271.1_2 - 5.3e-29 100.0 0.4 1.1e-28 98.9 0.4 1.6 1 0 0 1 1 1 1 Bucentaur or craniofacial development Tmemb_9 PF05434.9 MSTRG.12271.1_2 - 1.7 8.4 7.8 5.2 6.8 0.0 3.9 4 1 1 5 5 5 0 TMEM9 DUF423 PF04241.13 MSTRG.6638.1_2 - 1.3e-22 79.7 1.2 2.1e-22 79.0 1.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF423) CCCAP PF15964.3 MSTRG.26287.1_2 - 7.3e-48 163.3 17.2 9.4e-43 146.4 17.2 3.0 1 1 0 1 1 1 1 Centrosomal colon cancer autoantigen protein family SlyX PF04102.10 MSTRG.26287.1_2 - 0.0038 17.7 3.4 0.0038 17.7 3.4 3.8 4 0 0 4 4 4 1 SlyX MCC-bdg_PDZ PF10506.7 MSTRG.26287.1_2 - 0.0087 15.9 2.6 0.0087 15.9 2.6 3.2 4 0 0 4 4 4 1 PDZ domain of MCC-2 bdg protein for Usher syndrome Sipho_Gp157 PF05565.9 MSTRG.26287.1_2 - 0.012 15.6 4.1 0.16 11.8 0.1 2.8 3 0 0 3 3 3 0 Siphovirus Gp157 ZapB PF06005.10 MSTRG.26287.1_2 - 0.014 15.7 4.2 0.014 15.7 4.2 3.7 2 2 1 3 3 3 0 Cell division protein ZapB ATG16 PF08614.9 MSTRG.26287.1_2 - 0.017 15.2 2.4 0.017 15.2 2.4 3.2 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) GAS PF13851.4 MSTRG.26287.1_2 - 0.019 14.2 11.1 0.11 11.7 0.0 3.2 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding SOGA PF11365.6 MSTRG.26287.1_2 - 0.023 15.7 2.5 0.023 15.7 2.5 2.9 2 1 0 3 3 3 0 Protein SOGA ADIP PF11559.6 MSTRG.26287.1_2 - 0.036 14.0 1.7 0.036 14.0 1.7 3.1 3 1 0 3 3 3 0 Afadin- and alpha -actinin-Binding bZIP_1 PF00170.19 MSTRG.26287.1_2 - 0.082 12.9 0.5 0.082 12.9 0.5 3.8 3 1 0 3 3 3 0 bZIP transcription factor DUF4061 PF13270.4 MSTRG.26287.1_2 - 2.5 8.4 10.5 0.097 12.9 2.7 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4061) SKA2 PF16740.3 MSTRG.26287.1_2 - 2.6 7.7 13.4 0.057 13.1 0.6 3.2 3 1 0 3 3 3 0 Spindle and kinetochore-associated protein 2 Prefoldin_2 PF01920.18 MSTRG.26287.1_2 - 4.4 7.2 11.0 8.9 6.2 0.3 3.4 3 0 0 3 3 3 0 Prefoldin subunit Spc24 PF08286.9 MSTRG.26287.1_2 - 5.1 7.3 10.2 14 5.8 0.8 3.2 3 0 0 3 3 3 0 Spc24 subunit of Ndc80 DUF972 PF06156.11 MSTRG.26287.1_2 - 5.7 7.5 11.6 5 7.7 6.1 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF972) TMF_TATA_bd PF12325.6 MSTRG.26287.1_2 - 6.9 6.8 14.6 8.3 6.5 0.4 3.8 3 1 1 4 4 4 0 TATA element modulatory factor 1 TATA binding HAUS-augmin3 PF14932.4 MSTRG.26287.1_2 - 7 6.0 12.1 11 5.3 8.0 2.6 2 1 1 3 3 3 0 HAUS augmin-like complex subunit 3 TBPIP PF07106.11 MSTRG.26287.1_2 - 7.1 6.2 9.4 8.8 5.9 0.2 3.0 3 0 0 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Cep57_MT_bd PF06657.11 MSTRG.26287.1_2 - 7.6 6.9 16.5 1.8 8.9 1.8 3.5 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Orthopox_A36R PF05950.9 MSTRG.26224.1_3 - 0.26 11.3 0.1 0.26 11.3 0.1 1.5 2 0 0 2 2 2 0 Orthopoxvirus A36R protein Toxin_20 PF08089.9 MSTRG.7911.2_1 - 0.052 13.5 0.6 0.17 11.9 0.6 1.9 1 0 0 1 1 1 0 Huwentoxin-II family GST_C_2 PF13410.4 MSTRG.7911.2_3 - 2e-08 33.9 0.0 4e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.4 MSTRG.7911.2_3 - 8e-05 22.8 0.0 0.00014 22.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.4 MSTRG.7911.2_3 - 0.00031 20.9 0.0 0.00057 20.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain RasGEF PF00617.17 MSTRG.8944.1_1 - 5.2e-20 72.2 0.4 5.6e-20 72.1 0.4 1.0 1 0 0 1 1 1 1 RasGEF domain tRNA_int_endo PF01974.15 MSTRG.10099.1_1 - 8.3e-18 64.1 0.0 1.6e-17 63.2 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain Methyltransf_25 PF13649.4 MSTRG.1321.1_3 - 8.5e-05 23.1 0.0 0.0002 21.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 MSTRG.1321.1_3 - 0.00049 20.5 0.4 0.0013 19.2 0.1 1.9 2 0 0 2 2 2 1 Methyltransferase domain CheR PF01739.16 MSTRG.1321.1_3 - 0.00061 19.2 0.0 0.00096 18.6 0.0 1.2 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_12 PF08242.10 MSTRG.1321.1_3 - 0.0012 19.4 0.0 0.0028 18.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Rsm22 PF09243.8 MSTRG.1321.1_3 - 0.072 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 CMAS PF02353.18 MSTRG.1321.1_3 - 0.099 11.8 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_9 PF08003.9 MSTRG.1321.1_3 - 0.16 10.8 0.0 0.27 10.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) CAMSAP_CKK PF08683.9 MSTRG.309.1_3 - 6.7e-54 181.0 0.1 1.2e-53 180.3 0.1 1.4 1 0 0 1 1 1 1 Microtubule-binding calmodulin-regulated spectrin-associated CAMSAP_CH PF11971.6 MSTRG.309.1_3 - 5.8e-29 99.6 0.7 1.6e-28 98.2 0.4 2.0 2 0 0 2 2 2 1 CAMSAP CH domain CAMSAP_CC1 PF17095.3 MSTRG.309.1_3 - 1.6e-23 82.1 3.7 1.6e-23 82.1 3.7 2.5 2 0 0 2 2 2 1 Spectrin-binding region of Ca2+-Calmodulin Thioesterase PF00975.18 MSTRG.28825.1_3 - 0.00085 19.4 0.1 0.001 19.1 0.1 1.1 1 0 0 1 1 1 1 Thioesterase domain 7tm_1 PF00001.19 MSTRG.5777.1_1 - 2.4e-50 171.1 21.5 3.3e-50 170.7 21.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 MSTRG.5777.1_1 - 1.9e-08 33.9 20.7 3.4e-08 33.1 20.7 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx NB PF04159.11 MSTRG.5777.1_1 - 0.05 13.5 0.1 0.19 11.6 0.1 1.9 1 0 0 1 1 1 0 NB glycoprotein SK_channel PF03530.12 MSTRG.5777.1_1 - 0.077 12.8 8.1 0.58 10.0 8.1 2.3 1 1 0 1 1 1 0 Calcium-activated SK potassium channel DEAD PF00270.27 MSTRG.26010.1_2 - 1.9e-36 125.3 0.0 3.3e-36 124.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.26010.1_2 - 5.7e-25 87.7 0.2 2.2e-23 82.6 0.2 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.26010.1_2 - 3.2e-05 23.9 0.0 5.1e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.4 MSTRG.26010.1_2 - 4.1e-05 22.9 0.0 6.6e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit Flavokinase PF01687.15 MSTRG.5720.1_3 - 1.5e-35 121.7 0.0 2.5e-35 121.0 0.0 1.3 1 0 0 1 1 1 1 Riboflavin kinase CABIT PF12736.5 MSTRG.25354.2_3 - 9.1e-72 241.6 1.1 1.2e-53 182.1 1.1 2.1 2 0 0 2 2 2 2 Cell-cycle sustaining, positive selection, SAM_1 PF00536.28 MSTRG.25354.2_3 - 0.0029 17.9 0.2 0.0071 16.6 0.2 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ion_trans PF00520.29 MSTRG.14090.1_2 - 6.2e-76 254.7 39.4 2.8e-52 177.2 25.3 2.1 2 0 0 2 2 2 2 Ion transport protein PKD_channel PF08016.10 MSTRG.14090.1_2 - 1.5e-07 30.4 22.3 1.8e-05 23.5 1.1 3.2 2 1 1 3 3 3 2 Polycystin cation channel GPHH PF16905.3 MSTRG.14090.1_2 - 4.2e-06 26.3 0.0 8e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated IQ PF00612.25 MSTRG.14090.1_2 - 0.0015 18.0 2.5 0.0037 16.8 2.5 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif IQCJ-SCHIP1 PF15157.4 MSTRG.14090.1_2 - 0.096 12.4 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif TMEM51 PF15345.4 MSTRG.14090.1_2 - 0.13 11.9 0.1 0.26 11.0 0.1 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 DUF4043 PF13252.4 MSTRG.14090.1_2 - 0.16 10.9 0.0 0.26 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4043) Ribosomal_L1 PF00687.19 MSTRG.3492.5_3 - 2.9e-47 160.9 0.4 2.9e-47 160.9 0.4 1.6 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family Presenilin PF01080.15 MSTRG.3492.5_3 - 2.1 6.9 3.9 2.9 6.4 3.9 1.1 1 0 0 1 1 1 0 Presenilin WAP PF00095.19 MSTRG.18223.1_1 - 4e-25 87.8 56.3 5.1e-09 36.2 12.1 3.4 3 0 0 3 3 3 3 WAP-type (Whey Acidic Protein) 'four-disulfide core' HOOK PF05622.10 MSTRG.14436.1_1 - 0.0016 16.6 0.3 0.002 16.2 0.3 1.1 1 0 0 1 1 1 1 HOOK protein SHE3 PF17078.3 MSTRG.14436.1_1 - 0.016 14.8 0.2 0.022 14.3 0.2 1.1 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 ADIP PF11559.6 MSTRG.14436.1_1 - 0.02 14.9 2.1 0.04 13.9 2.1 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding IncA PF04156.12 MSTRG.14436.1_1 - 0.022 14.4 3.2 0.034 13.8 3.2 1.2 1 0 0 1 1 1 0 IncA protein SlyX PF04102.10 MSTRG.14436.1_1 - 0.054 14.0 0.6 0.22 12.0 0.6 2.1 1 1 0 1 1 1 0 SlyX Jnk-SapK_ap_N PF09744.7 MSTRG.14436.1_1 - 0.06 13.4 1.7 0.12 12.5 1.7 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 CENP-F_leu_zip PF10473.7 MSTRG.14436.1_1 - 0.074 12.9 1.3 0.13 12.1 1.3 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cnn_1N PF07989.9 MSTRG.14436.1_1 - 0.093 12.7 0.3 0.093 12.7 0.3 1.9 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Spc7 PF08317.9 MSTRG.14436.1_1 - 0.12 11.1 1.8 0.17 10.6 1.8 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.10 MSTRG.14436.1_1 - 0.15 12.0 2.1 0.27 11.2 2.1 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein K-box PF01486.15 MSTRG.14436.1_1 - 0.19 11.8 2.4 3.1 7.9 2.6 2.4 1 1 1 2 2 2 0 K-box region DUF2721 PF11026.6 MSTRG.14436.1_1 - 0.26 11.1 1.0 0.46 10.2 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) bZIP_1 PF00170.19 MSTRG.14436.1_1 - 1.2 9.2 11.0 1.6 8.7 0.2 3.0 3 0 0 3 3 3 0 bZIP transcription factor NO_synthase PF02898.13 MSTRG.16777.5_3 - 2.3e-189 628.9 0.0 3.2e-189 628.4 0.0 1.2 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain FAD_binding_1 PF00667.18 MSTRG.16777.5_3 - 4.5e-80 268.2 0.1 7.8e-80 267.5 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.23 MSTRG.16777.5_3 - 6.3e-53 178.7 0.1 1.2e-52 177.8 0.1 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.19 MSTRG.16777.5_3 - 7.6e-20 71.5 0.0 1.8e-19 70.3 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain SASA PF03629.16 MSTRG.4366.1_2 - 6.3e-13 48.8 0.0 1.2e-12 47.8 0.0 1.4 1 1 0 1 1 1 1 Carbohydrate esterase, sialic acid-specific acetylesterase Big_1 PF02369.14 MSTRG.4366.1_2 - 0.021 14.7 0.0 0.034 14.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) DUF3915 PF13054.4 MSTRG.1695.2_1 - 0.08 12.8 0.8 0.13 12.1 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 MSTRG.1695.2_1 - 0.26 9.4 3.6 0.35 9.0 3.6 1.0 1 0 0 1 1 1 0 Atrophin-1 family LIDHydrolase PF10230.7 MSTRG.1695.2_3 - 4e-79 265.8 0.0 4.9e-79 265.5 0.0 1.1 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_6 PF12697.5 MSTRG.1695.2_3 - 2.6e-05 24.8 0.0 3.4e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.18 MSTRG.1695.2_3 - 4.2e-05 23.2 0.0 0.00056 19.5 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 MSTRG.1695.2_3 - 0.00027 20.2 0.0 0.00037 19.7 0.0 1.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.11 MSTRG.1695.2_3 - 0.049 13.4 0.0 0.084 12.6 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase C1_1 PF00130.20 MSTRG.29449.1_3 - 0.021 14.6 0.1 2.1 8.1 0.0 2.4 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) CDT1_C PF16679.3 MSTRG.29449.1_3 - 0.13 12.6 0.1 0.18 12.1 0.1 1.2 1 0 0 1 1 1 0 DNA replication factor Cdt1 C-terminal domain PDZ PF00595.22 MSTRG.16502.2_1 - 2.5e-13 50.0 0.5 4.5e-13 49.2 0.5 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.16502.2_1 - 0.0051 17.0 0.0 0.01 16.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain HisKA_3 PF07730.11 MSTRG.16502.2_1 - 0.085 13.3 4.2 0.24 11.8 4.2 1.8 1 0 0 1 1 1 0 Histidine kinase 2OG-FeII_Oxy_2 PF13532.4 MSTRG.16502.2_2 - 6e-37 127.7 0.0 1.1e-36 126.8 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-C4 PF00105.16 MSTRG.20825.1_2 - 5.4e-31 106.7 18.3 9.6e-31 105.9 18.3 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 MSTRG.20825.1_2 - 1.1e-14 54.4 0.1 1.7e-14 53.7 0.1 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Pkinase PF00069.23 MSTRG.22199.1_1 - 1.4e-51 175.3 0.0 1.8e-51 174.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.22199.1_1 - 1e-21 77.2 0.0 1.6e-21 76.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Thioredoxin PF00085.18 MSTRG.8933.1_2 - 4.6e-21 74.6 0.0 9.1e-21 73.6 0.0 1.5 2 0 0 2 2 2 1 Thioredoxin FAM176 PF14851.4 MSTRG.8933.1_2 - 0.0013 18.3 0.5 0.0022 17.5 0.0 1.6 2 0 0 2 2 2 1 FAM176 family OST3_OST6 PF04756.11 MSTRG.8933.1_2 - 0.0022 17.3 0.0 0.0039 16.5 0.0 1.4 1 1 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.4 MSTRG.8933.1_2 - 0.0086 16.4 0.1 0.027 14.8 0.1 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Astro_capsid_p PF12226.6 MSTRG.8933.1_2 - 0.014 14.4 1.0 0.02 14.0 1.0 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein TRAP_alpha PF03896.14 MSTRG.8933.1_2 - 0.04 13.0 0.6 0.061 12.4 0.6 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit TraF PF13728.4 MSTRG.8933.1_2 - 0.047 13.4 0.0 0.047 13.4 0.0 2.0 2 0 0 2 2 2 0 F plasmid transfer operon protein DUF3328 PF11807.6 MSTRG.8933.1_2 - 0.083 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) Goodbye PF17109.3 MSTRG.8933.1_2 - 1.2 9.4 0.0 1.2 9.4 0.0 2.0 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain DUF4611 PF15387.4 MSTRG.8933.1_2 - 3 8.0 10.1 5.2 7.2 10.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) DNA_pol_phi PF04931.11 MSTRG.8933.1_2 - 6.2 4.7 12.4 8.5 4.2 12.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.10 MSTRG.8933.1_2 - 6.6 5.9 11.1 10 5.3 11.1 1.2 1 0 0 1 1 1 0 NOA36 protein CD36 PF01130.19 MSTRG.15218.2_2 - 8.5e-18 64.0 0.1 1.1e-17 63.7 0.1 1.1 1 0 0 1 1 1 1 CD36 family CD36 PF01130.19 MSTRG.15218.2_3 - 3.7e-105 352.0 0.0 4.9e-105 351.6 0.0 1.1 1 0 0 1 1 1 1 CD36 family CUB PF00431.18 MSTRG.16622.1_3 - 7.4e-07 29.3 0.0 5.4e-06 26.6 0.0 2.2 2 0 0 2 2 2 1 CUB domain GN3L_Grn1 PF08701.9 MSTRG.13843.1_3 - 2.2e-23 82.0 21.7 2.2e-23 82.0 21.7 3.5 3 1 1 4 4 4 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.21 MSTRG.13843.1_3 - 3.4e-15 56.0 0.1 6.1e-14 52.0 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.16 MSTRG.13843.1_3 - 1.6e-08 34.1 0.3 1.1e-05 24.9 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.25 MSTRG.13843.1_3 - 3.7e-06 26.5 0.2 0.0036 16.7 0.0 3.4 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain DUF258 PF03193.14 MSTRG.13843.1_3 - 3.7e-05 23.6 1.0 0.23 11.2 0.1 2.4 1 1 1 2 2 2 2 Protein of unknown function, DUF258 ArgK PF03308.14 MSTRG.13843.1_3 - 0.12 11.2 0.1 0.27 10.0 0.1 1.5 1 0 0 1 1 1 0 ArgK protein TrwC PF08751.9 MSTRG.13843.1_3 - 7.4 5.9 15.1 14 4.9 15.1 1.4 1 0 0 1 1 1 0 TrwC relaxase DUF3498 PF12004.6 MSTRG.10429.1_3 - 5.7e-72 243.5 29.7 2.2e-56 192.1 13.5 3.7 2 1 1 3 3 3 2 Domain of unknown function (DUF3498) RasGAP PF00616.17 MSTRG.10429.1_3 - 8.3e-26 90.8 0.0 4.7e-14 52.4 0.0 2.3 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.28 MSTRG.10429.1_3 - 2e-08 34.3 0.0 3.6e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 C2 domain PH PF00169.27 MSTRG.10429.1_3 - 0.00014 22.2 0.0 0.45 10.9 0.0 2.8 2 0 0 2 2 2 2 PH domain PH_6 PF15406.4 MSTRG.10429.1_3 - 0.051 13.7 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain DREV PF05219.10 MSTRG.4788.1_3 - 1.1e-105 352.3 0.0 1.4e-105 352.0 0.0 1.1 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_23 PF13489.4 MSTRG.4788.1_3 - 4.6e-12 46.0 0.0 6.9e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 MSTRG.4788.1_3 - 2.2e-07 31.4 0.0 4.7e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 MSTRG.4788.1_3 - 6.7e-07 29.7 0.0 1.2e-06 29.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 MSTRG.4788.1_3 - 3.7e-05 24.2 0.0 6.6e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 MSTRG.4788.1_3 - 0.037 13.7 0.0 1.6 8.4 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain Spp-24 PF07448.9 MSTRG.2260.2_1 - 0.024 14.7 0.3 0.049 13.7 0.3 1.5 1 0 0 1 1 1 0 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain RYDR_ITPR PF01365.19 MSTRG.22045.1_3 - 1.3e-68 230.3 26.6 7.2e-60 201.8 1.8 4.6 4 1 1 5 5 5 3 RIH domain MIR PF02815.17 MSTRG.22045.1_3 - 2.9e-66 222.7 0.7 8.1e-66 221.3 0.1 2.1 2 0 0 2 2 2 1 MIR domain Ins145_P3_rec PF08709.9 MSTRG.22045.1_3 - 1.2e-45 155.2 0.0 1.1e-44 152.1 0.0 2.3 1 1 1 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor RIH_assoc PF08454.9 MSTRG.22045.1_3 - 6.2e-34 115.7 21.3 1.1e-31 108.6 5.9 4.8 5 0 0 5 5 5 2 RyR and IP3R Homology associated Ion_trans PF00520.29 MSTRG.22045.1_3 - 7.7e-18 64.5 12.7 1.7e-17 63.3 12.7 1.6 1 0 0 1 1 1 1 Ion transport protein Sec2p PF06428.9 MSTRG.22045.1_3 - 0.18 11.6 6.3 0.67 9.8 6.3 2.0 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p DUF2207 PF09972.7 MSTRG.22045.1_3 - 1 7.9 7.8 1.1e+02 1.2 7.8 2.9 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) zf-H2C2_2 PF13465.4 MSTRG.17527.1_3 - 1.5e-78 255.9 83.4 2.3e-09 37.2 3.5 13.0 12 0 0 12 12 12 10 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.17527.1_3 - 1.7e-51 169.8 111.5 1.2e-06 28.5 4.3 12.9 12 0 0 12 12 12 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.17527.1_3 - 9.8e-38 125.4 96.9 0.00046 20.6 1.3 13.3 12 0 0 12 12 12 12 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 MSTRG.17527.1_3 - 9.6e-18 63.9 57.9 0.00038 20.5 0.0 12.4 12 0 0 12 12 12 7 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 MSTRG.17527.1_3 - 2.9e-12 46.1 76.9 9.6e-05 22.1 1.5 12.5 12 0 0 12 12 12 8 C2H2-type zinc finger zf-Di19 PF05605.10 MSTRG.17527.1_3 - 3.2e-11 43.2 56.4 0.0014 18.8 1.1 8.3 4 2 4 9 9 9 7 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.4 MSTRG.17527.1_3 - 8.9e-08 31.6 70.7 0.014 15.0 0.3 11.3 10 0 0 10 10 10 7 C2H2-type zinc-finger domain BolA PF01722.16 MSTRG.17527.1_3 - 4.1e-06 26.9 14.2 0.21 11.8 0.0 6.5 4 3 3 7 7 7 2 BolA-like protein zf-met PF12874.5 MSTRG.17527.1_3 - 5.8e-06 26.4 81.2 0.11 12.8 2.2 13.1 12 1 0 12 12 12 6 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.3 MSTRG.17527.1_3 - 0.36 11.5 41.7 6.5 7.5 0.9 7.6 4 2 3 7 7 7 0 zinc-ribbon family zf-C2H2_11 PF16622.3 MSTRG.17527.1_3 - 1 9.1 29.7 0.45 10.2 0.2 6.6 5 0 0 5 5 5 0 zinc-finger C2H2-type zf-C2H2_2 PF12756.5 MSTRG.17527.1_3 - 3.4 7.9 60.9 0.95 9.7 9.7 10.3 2 2 6 9 9 9 0 C2H2 type zinc-finger (2 copies) FGE-sulfatase PF03781.14 MSTRG.14104.2_1 - 1.1e-64 218.4 2.2 4.1e-53 180.5 0.1 2.2 1 1 1 2 2 2 2 Sulfatase-modifying factor enzyme 1 Sulfate_transp PF00916.18 MSTRG.3131.1_2 - 8.1e-08 31.3 0.2 8.9e-08 31.1 0.2 1.0 1 0 0 1 1 1 1 Sulfate permease family WD40 PF00400.30 MSTRG.845.1_1 - 0.0034 18.1 0.0 11 6.9 0.0 3.9 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.845.1_1 - 0.0055 16.8 0.0 0.25 11.5 0.0 2.8 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain CPSF_A PF03178.13 MSTRG.845.1_1 - 0.051 12.8 0.1 0.57 9.3 0.0 2.2 2 1 0 2 2 2 0 CPSF A subunit region F-box-like PF12937.5 MSTRG.12929.1_2 - 3.1e-09 36.4 1.1 3.1e-09 36.4 1.1 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.31 MSTRG.12929.1_2 - 1e-05 25.2 1.1 1e-05 25.2 1.1 2.1 2 0 0 2 2 2 1 F-box domain HCO3_cotransp PF00955.19 MSTRG.19619.1_1 - 9e-107 357.9 1.0 1e-106 357.8 1.0 1.0 1 0 0 1 1 1 1 HCO3- transporter family Caprin-1_C PF12287.6 MSTRG.5815.2_2 - 3.3e-104 349.5 35.7 9.1e-78 262.6 21.5 3.2 2 1 1 3 3 3 2 Cytoplasmic activation/proliferation-associated protein-1 C term DUF1140 PF06600.9 MSTRG.5815.2_2 - 0.021 15.1 1.6 0.038 14.3 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1140) DUF1940 PF09155.8 MSTRG.5815.2_2 - 0.06 13.3 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1940) DUF4208 PF13907.4 MSTRG.5815.2_2 - 0.22 11.9 3.2 0.25 11.7 1.5 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4208) HSA PF07529.11 MSTRG.5815.2_2 - 10 6.4 9.4 1.1 9.5 3.0 2.3 2 0 0 2 2 2 0 HSA V_ATPase_I PF01496.17 MSTRG.10274.1_1 - 6.9e-293 973.4 0.0 8.6e-293 973.1 0.0 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Takusan PF04822.11 MSTRG.10274.1_1 - 0.013 15.2 0.4 0.026 14.3 0.4 1.4 1 0 0 1 1 1 0 Takusan Pkinase_Tyr PF07714.15 MSTRG.4663.1_1 - 1.1e-94 316.5 0.0 1.5e-94 316.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.4663.1_1 - 2.2e-41 141.8 0.0 4.5e-41 140.8 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Kinase-like PF14531.4 MSTRG.4663.1_1 - 0.001 18.3 0.0 0.0014 17.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like fn3 PF00041.19 MSTRG.4663.1_1 - 0.088 13.0 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Fibronectin type III domain DUF4476 PF14771.4 MSTRG.4663.1_1 - 0.09 13.0 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4476) B2 PF11473.6 MSTRG.4663.1_1 - 0.096 12.4 0.1 0.21 11.3 0.1 1.5 1 0 0 1 1 1 0 RNA binding protein B2 PspB PF06667.10 MSTRG.4663.1_1 - 0.17 11.8 0.6 2 8.4 0.1 2.6 3 0 0 3 3 3 0 Phage shock protein B Acyl-CoA_dh_M PF02770.17 MSTRG.5641.3_2 - 2e-07 31.0 0.1 3.1e-07 30.3 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.22 MSTRG.5641.3_3 - 2.4e-22 79.6 1.0 3.2e-22 79.2 1.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.9 MSTRG.5641.3_3 - 1.2e-08 35.2 0.1 1.7e-08 34.7 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.17 MSTRG.5641.3_3 - 0.0015 18.5 0.0 0.0028 17.7 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain UCH PF00443.27 MSTRG.27834.1_1 - 8.7e-57 192.4 0.0 1.2e-55 188.7 0.0 2.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 MSTRG.27834.1_1 - 1.4e-10 41.2 9.2 7.7e-08 32.2 0.0 2.8 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase WD40 PF00400.30 MSTRG.27834.1_1 - 1.6e-09 38.1 1.9 0.00021 21.9 0.0 4.5 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 MSTRG.27834.1_1 - 0.13 12.4 0.1 0.85 9.8 0.0 2.2 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain TetR_C_13 PF16925.3 MSTRG.27834.1_1 - 0.22 11.3 1.1 0.56 10.0 0.8 1.7 2 0 0 2 2 2 0 Bacterial transcriptional repressor C-terminal WD40 PF00400.30 MSTRG.27834.1_3 - 0.0087 16.8 0.0 0.038 14.8 0.0 2.2 1 0 0 1 1 1 1 WD domain, G-beta repeat CiPC PF15800.3 MSTRG.1591.1_2 - 1e-94 317.9 32.4 1.2e-58 199.4 25.0 2.2 1 1 1 2 2 2 2 Clock interacting protein circadian RabGAP-TBC PF00566.16 MSTRG.3805.1_1 - 2.6e-43 148.0 0.2 1.4e-42 145.7 0.0 2.3 2 0 0 2 2 2 1 Rab-GTPase-TBC domain GRAM PF02893.18 MSTRG.3805.1_1 - 3.2e-31 107.4 0.2 2.4e-17 62.7 0.0 2.5 2 0 0 2 2 2 2 GRAM domain EF-hand_1 PF00036.30 MSTRG.3805.1_1 - 0.00013 21.1 0.1 0.00049 19.3 0.1 2.1 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.4 MSTRG.3805.1_1 - 0.0023 17.5 0.8 0.011 15.4 0.1 2.5 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.3805.1_1 - 0.0092 15.7 0.0 0.044 13.6 0.0 2.2 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.4 MSTRG.3805.1_1 - 0.077 12.4 0.1 0.25 10.8 0.1 1.8 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.4 MSTRG.3805.1_1 - 0.096 13.0 0.8 0.34 11.3 0.1 2.2 2 0 0 2 2 2 0 EF-hand domain pair COE1_DBD PF16422.3 MSTRG.25814.1_3 - 9.1e-124 411.2 0.1 1.1e-123 410.9 0.1 1.1 1 0 0 1 1 1 1 Transcription factor COE1 DNA-binding domain Pkinase PF00069.23 MSTRG.11498.1_1 - 6.9e-65 218.9 0.0 9.6e-65 218.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.11498.1_1 - 2e-39 135.3 0.0 3.1e-39 134.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 MSTRG.11498.1_1 - 2.2e-31 107.4 31.9 3.9e-17 61.7 5.3 3.1 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C2 PF00168.28 MSTRG.11498.1_1 - 3.6e-27 94.5 0.0 5.7e-27 93.9 0.0 1.3 1 0 0 1 1 1 1 C2 domain Pkinase_C PF00433.22 MSTRG.11498.1_1 - 7.8e-05 23.2 1.1 0.00017 22.0 1.1 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain C1_2 PF03107.14 MSTRG.11498.1_1 - 0.012 15.7 19.5 0.32 11.2 7.0 2.9 2 0 0 2 2 2 0 C1 domain APH PF01636.21 MSTRG.11498.1_1 - 0.18 11.6 0.0 0.38 10.5 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family PHD_2 PF13831.4 MSTRG.11498.1_1 - 0.78 9.2 13.1 2.8 7.4 1.2 3.2 2 0 0 2 2 2 0 PHD-finger C2 PF00168.28 MSTRG.14572.1_3 - 2e-16 60.0 0.2 2.3e-16 59.8 0.2 1.0 1 0 0 1 1 1 1 C2 domain BACK PF07707.13 MSTRG.24142.1_3 - 0.00054 19.9 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 BTB And C-terminal Kelch V-set PF07686.15 MSTRG.9859.1_2 - 1e-12 48.0 0.0 1.7e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 MSTRG.9859.1_2 - 8.7e-06 26.1 0.0 1.7e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 MSTRG.9859.1_2 - 1.6e-05 24.9 0.0 2.9e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 MSTRG.9859.1_2 - 0.091 12.7 0.0 0.19 11.7 0.0 1.5 1 1 0 1 1 1 0 Immunoglobulin I-set domain PRY PF13765.4 MSTRG.4900.4_3 - 1.9e-12 46.5 1.0 4.6e-12 45.2 0.0 2.2 3 0 0 3 3 3 1 SPRY-associated domain zf-C3HC4_2 PF13923.4 MSTRG.4900.4_3 - 2.6e-08 33.4 8.0 6.7e-08 32.1 8.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 MSTRG.4900.4_3 - 3.3e-08 33.1 6.5 9.3e-08 31.7 6.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 MSTRG.4900.4_3 - 4.8e-07 29.7 5.7 4.8e-07 29.7 5.7 2.6 3 0 0 3 3 2 1 B-box zinc finger zf-C3HC4_3 PF13920.4 MSTRG.4900.4_3 - 2.7e-06 27.0 5.0 2.7e-06 27.0 5.0 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 MSTRG.4900.4_3 - 4e-06 26.8 8.5 4e-06 26.8 8.5 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.4 MSTRG.4900.4_3 - 5.6e-06 26.4 9.6 5.6e-06 26.4 9.6 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.4 MSTRG.4900.4_3 - 8.2e-06 25.6 4.0 2.4e-05 24.1 4.0 1.9 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.4 MSTRG.4900.4_3 - 8.3e-05 22.2 7.0 8.3e-05 22.2 7.0 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 MSTRG.4900.4_3 - 0.0004 20.1 5.0 0.0004 20.1 5.0 2.0 2 0 0 2 2 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.3 MSTRG.4900.4_3 - 0.0015 18.0 7.9 0.0036 16.8 7.9 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.5 MSTRG.4900.4_3 - 0.01 15.9 8.9 0.01 15.9 8.9 2.6 2 0 0 2 2 2 0 RING-H2 zinc finger domain SPRY PF00622.26 MSTRG.4900.4_3 - 0.059 13.4 0.0 0.18 11.8 0.0 1.9 1 0 0 1 1 1 0 SPRY domain IncA PF04156.12 MSTRG.4900.4_3 - 0.26 10.9 4.6 0.5 10.0 4.6 1.5 1 0 0 1 1 1 0 IncA protein APG6 PF04111.10 MSTRG.4900.4_3 - 0.33 10.2 7.0 0.48 9.6 7.0 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Spc7 PF08317.9 MSTRG.4900.4_3 - 0.37 9.5 8.5 0.54 8.9 8.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein AAA_23 PF13476.4 MSTRG.4900.4_3 - 0.71 10.2 5.4 1.1 9.6 5.4 1.2 1 0 0 1 1 1 0 AAA domain zf-ANAPC11 PF12861.5 MSTRG.4900.4_3 - 1.1 9.2 10.4 0.19 11.7 5.8 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF4140 PF13600.4 MSTRG.4900.4_3 - 9.6 6.6 8.0 35 4.8 8.0 1.9 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Epimerase PF01370.19 MSTRG.1774.1_3 - 6.5e-54 182.8 0.1 1.3e-53 181.8 0.0 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 MSTRG.1774.1_3 - 4e-14 52.6 0.1 1.2e-13 51.0 0.0 1.7 1 1 1 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.15 MSTRG.1774.1_3 - 3.1e-07 29.7 0.0 7.2e-07 28.4 0.0 1.6 2 0 0 2 2 2 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.13 MSTRG.1774.1_3 - 0.0001 21.4 1.6 0.00097 18.2 0.1 2.4 2 1 1 3 3 3 2 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.17 MSTRG.1774.1_3 - 0.00026 20.0 0.6 0.0026 16.7 0.6 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DUF2464 PF10240.7 MSTRG.18907.1_3 - 7.7e-75 251.5 0.0 9.4e-75 251.2 0.0 1.1 1 0 0 1 1 1 1 Multivesicular body subunit 12 TP_methylase PF00590.18 MSTRG.24363.2_2 - 9.4e-19 68.0 0.3 7.2e-18 65.2 0.3 2.3 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Adaptin_N PF01602.18 MSTRG.23696.2_3 - 2.6e-151 504.6 12.9 3.3e-151 504.3 12.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region AP3D1 PF06375.9 MSTRG.23696.2_3 - 2.5e-47 161.0 15.5 2.5e-47 161.0 15.5 3.4 2 1 1 3 3 3 1 AP-3 complex subunit delta-1 Cnd1 PF12717.5 MSTRG.23696.2_3 - 8.8e-15 54.9 9.8 5.3e-11 42.7 0.0 4.2 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.20 MSTRG.23696.2_3 - 8.7e-07 28.5 0.2 0.47 10.7 0.0 5.1 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.4 MSTRG.23696.2_3 - 1.3e-05 25.3 0.0 0.1 12.9 0.0 3.6 2 1 0 3 3 3 1 HEAT repeats RTP1_C1 PF10363.7 MSTRG.23696.2_3 - 5.8e-05 23.1 4.6 0.88 9.6 1.0 4.0 4 0 0 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 RasGEF_N_2 PF14663.4 MSTRG.23696.2_3 - 0.0066 16.6 0.1 0.17 12.1 0.3 2.7 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain DUF4507 PF14964.4 MSTRG.12087.1_2 - 4.8e-65 219.7 0.4 5.4e-65 219.5 0.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4507) Vps39_2 PF10367.7 MSTRG.21298.1_1 - 0.13 12.5 5.4 0.11 12.8 0.7 2.7 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 2 RVT_1 PF00078.25 MSTRG.21298.1_2 - 0.0029 17.0 0.0 0.004 16.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1891 PF09004.8 MSTRG.21298.1_3 - 1.1e-06 28.0 0.3 3.2e-06 26.5 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1891) FAM53 PF15242.4 MSTRG.4893.1_3 - 3.9e-70 237.0 21.6 4.3e-46 158.0 11.4 2.3 1 1 1 2 2 2 2 Family of FAM53 DUF4280 PF14107.4 MSTRG.10690.8_1 - 0.65 10.7 2.3 7.6 7.3 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4280) TNFR_c6 PF00020.16 MSTRG.17646.4_1 - 9.5e-14 51.4 50.3 8.1e-09 35.6 12.2 3.9 3 0 0 3 3 3 2 TNFR/NGFR cysteine-rich region Death PF00531.20 MSTRG.17646.4_2 - 7.7e-12 45.1 0.1 1.3e-11 44.3 0.1 1.3 1 0 0 1 1 1 1 Death domain Repressor_Mnt PF11423.6 MSTRG.8046.1_1 - 0.029 14.0 0.1 0.044 13.4 0.1 1.2 1 0 0 1 1 1 0 Regulatory protein Mnt HLH PF00010.24 MSTRG.17317.1_3 - 2.6e-10 40.0 1.3 7.8e-10 38.4 1.3 1.9 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Cas_Csy4 PF09618.8 MSTRG.17317.1_3 - 0.13 12.3 0.3 0.87 9.6 0.0 2.1 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csy4) CDC45 PF02724.12 MSTRG.17317.1_3 - 0.52 8.4 5.1 0.73 7.9 5.1 1.1 1 0 0 1 1 1 0 CDC45-like protein ArfGap PF01412.16 MSTRG.27850.2_3 - 3.4e-28 97.9 1.2 3.4e-28 97.9 1.2 1.8 1 1 1 2 2 2 1 Putative GTPase activating protein for Arf zf-RanBP PF00641.16 MSTRG.27850.2_3 - 4.5 6.5 12.1 0.69 9.2 0.3 3.1 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others SRI PF08236.9 MSTRG.9574.1_1 - 2.6e-27 94.7 3.5 1.1e-26 92.7 3.5 2.2 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.26 MSTRG.9574.1_1 - 2.1e-19 70.4 0.1 2.1e-19 70.4 0.1 5.6 5 2 0 5 5 5 2 SET domain WW PF00397.24 MSTRG.9574.1_1 - 5e-10 39.0 2.3 5e-10 39.0 2.3 2.3 2 0 0 2 2 2 1 WW domain p450 PF00067.20 MSTRG.12933.10_2 - 3.3e-128 428.2 0.2 4e-128 427.9 0.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.20 MSTRG.12933.10_3 - 7.1e-97 324.9 0.2 9.8e-97 324.4 0.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 RhoGEF PF00621.18 MSTRG.6932.2_2 - 4.7e-33 114.8 0.7 6.8e-33 114.3 0.2 1.5 2 0 0 2 2 2 1 RhoGEF domain Strumpellin PF10266.7 MSTRG.23096.1_3 - 0 1639.1 19.3 0 1638.9 19.3 1.0 1 0 0 1 1 1 1 Hereditary spastic paraplegia protein strumpellin VPS53_C PF16854.3 MSTRG.23096.1_3 - 0.42 10.3 6.0 1.5 8.5 0.4 3.4 3 0 0 3 3 3 0 Vacuolar protein sorting-associated protein 53 C-terminus IMD PF08397.9 MSTRG.12976.1_3 - 1e-91 306.0 4.3 1e-91 306.0 4.3 1.6 2 0 0 2 2 2 1 IRSp53/MIM homology domain TFIIA PF03153.11 MSTRG.12976.1_3 - 0.99 9.2 22.8 0.017 15.0 15.9 1.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SecY PF00344.18 MSTRG.13632.7_2 - 2.5e-76 256.7 12.0 3.3e-76 256.3 12.0 1.2 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.7 MSTRG.13632.7_2 - 1.5e-18 66.2 0.2 4e-18 64.8 0.2 1.8 1 0 0 1 1 1 1 Plug domain of Sec61p DUF2975 PF11188.6 MSTRG.13632.7_2 - 5.8 6.7 11.4 0.11 12.3 1.2 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF2975) PDZ PF00595.22 MSTRG.18728.2_2 - 4.7e-46 154.9 5.3 1.3e-17 63.8 0.4 3.6 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 MSTRG.18728.2_2 - 1e-13 51.2 0.5 0.00017 21.7 0.1 3.6 3 0 0 3 3 3 3 PDZ domain PH PF00169.27 MSTRG.643.1_1 - 9.7e-07 29.1 0.1 1.5e-06 28.5 0.1 1.3 1 0 0 1 1 1 1 PH domain PH_10 PF15411.4 MSTRG.643.1_1 - 0.00022 21.4 1.9 0.00068 19.7 1.8 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain zf-C2H2_2 PF12756.5 MSTRG.10474.1_3 - 3.9e-35 120.1 12.1 1.5e-28 99.0 0.7 3.4 2 1 1 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.6 MSTRG.10474.1_3 - 7.5e-10 38.7 13.2 2.9e-06 27.3 3.8 3.7 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 MSTRG.10474.1_3 - 7.8e-07 29.2 3.1 7.8e-07 29.2 3.1 3.1 4 0 0 4 4 4 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.4 MSTRG.10474.1_3 - 0.0021 18.6 0.3 0.0021 18.6 0.3 4.7 4 0 0 4 4 4 1 C2H2-type zinc finger DUF629 PF04780.10 MSTRG.10474.1_3 - 0.011 14.2 0.9 0.011 14.2 0.9 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF629) zf-C2H2 PF00096.24 MSTRG.10474.1_3 - 0.019 15.3 1.3 0.019 15.3 1.3 3.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-LYAR PF08790.9 MSTRG.10474.1_3 - 0.13 12.1 2.3 1.6 8.6 0.1 2.9 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger CENP-B_dimeris PF09026.8 MSTRG.10474.1_3 - 1.3 9.4 14.0 3.2 8.1 8.0 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain zf-DBF PF07535.10 MSTRG.10474.1_3 - 1.7 8.7 7.6 0.74 9.8 0.6 3.0 3 0 0 3 3 3 0 DBF zinc finger TFIIA PF03153.11 MSTRG.10474.1_3 - 2.3 8.0 17.2 3.8 7.3 17.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MIP-T3 PF10243.7 MSTRG.24101.2_2 - 3.4 6.1 8.4 4.4 5.8 8.4 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF3329 PF11808.6 MSTRG.5173.1_3 - 0.066 13.5 0.7 0.16 12.3 0.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3329) VHS PF00790.17 MSTRG.2580.3_3 - 9.9e-30 103.1 0.0 1.9e-29 102.2 0.0 1.4 1 0 0 1 1 1 1 VHS domain GAT PF03127.12 MSTRG.2580.3_3 - 1.2e-25 89.5 1.5 2.4e-25 88.5 1.5 1.6 1 0 0 1 1 1 1 GAT domain ENTH PF01417.18 MSTRG.2580.3_3 - 0.19 11.6 0.0 0.35 10.8 0.0 1.3 1 0 0 1 1 1 0 ENTH domain Paxillin PF03535.11 MSTRG.2986.2_3 - 9.5e-74 247.5 23.3 1.6e-73 246.8 23.3 1.3 1 0 0 1 1 1 1 Paxillin family LIM PF00412.20 MSTRG.2986.2_3 - 3.3e-63 209.7 40.5 2.5e-16 59.5 1.3 4.3 4 0 0 4 4 4 4 LIM domain DUF1797 PF08796.8 MSTRG.2986.2_3 - 0.15 12.1 0.4 7.7 6.6 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1797) MAS20 PF02064.13 MSTRG.19347.1_3 - 4.2e-46 156.1 0.1 6.7e-46 155.4 0.1 1.3 1 0 0 1 1 1 1 MAS20 protein import receptor TPR_1 PF00515.26 MSTRG.19347.1_3 - 0.12 12.1 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat RSN1_7TM PF02714.13 MSTRG.19347.1_3 - 0.14 11.3 0.0 0.2 10.8 0.0 1.1 1 0 0 1 1 1 0 Calcium-dependent channel, 7TM region, putative phosphate Trypsin PF00089.24 MSTRG.8031.1_3 - 7.1e-08 32.4 0.0 1.9e-07 31.0 0.0 1.6 2 0 0 2 2 2 1 Trypsin Trypsin_2 PF13365.4 MSTRG.8031.1_3 - 3.1e-07 31.3 0.0 5.1e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain Augurin PF15187.4 MSTRG.22323.1_3 - 2.7e-59 198.2 1.7 3.6e-59 197.8 1.7 1.2 1 0 0 1 1 1 1 Oesophageal cancer-related gene 4 EGF PF00008.25 MSTRG.1890.1_1 - 1.2e-06 28.5 9.3 2.2e-06 27.7 9.3 1.5 1 0 0 1 1 1 1 EGF-like domain Chi-conotoxin PF16981.3 MSTRG.1890.1_1 - 0.0068 16.5 0.1 0.021 14.9 0.1 1.8 1 0 0 1 1 1 1 chi-Conotoxin or t superfamily hEGF PF12661.5 MSTRG.1890.1_1 - 0.014 16.0 4.6 0.014 16.0 4.6 2.0 2 0 0 2 2 2 0 Human growth factor-like EGF Herpes_gE PF02480.14 MSTRG.1890.1_1 - 0.04 12.5 0.2 0.21 10.2 0.0 1.9 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E EGF_2 PF07974.11 MSTRG.1890.1_1 - 0.4 11.0 11.1 0.96 9.7 11.1 1.7 1 0 0 1 1 1 0 EGF-like domain Sulfate_transp PF00916.18 MSTRG.11755.2_3 - 3.8e-115 384.5 23.8 5e-115 384.1 23.8 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.19 MSTRG.11755.2_3 - 1.2e-21 76.3 0.0 2.5e-21 75.3 0.0 1.6 1 0 0 1 1 1 1 STAS domain RhoGEF PF00621.18 MSTRG.3953.1_1 - 1.3e-19 71.0 1.0 3.2e-14 53.4 0.4 2.6 2 0 0 2 2 2 2 RhoGEF domain Snf7 PF03357.19 MSTRG.22915.1_2 - 6.3e-42 143.0 26.2 9e-42 142.5 26.2 1.1 1 0 0 1 1 1 1 Snf7 DUF3585 PF12130.6 MSTRG.22915.1_2 - 0.2 11.6 13.1 0.59 10.1 13.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3585) DnaJ-X PF14308.4 MSTRG.22915.1_2 - 1.3 8.3 17.3 0.33 10.3 13.9 1.6 1 1 0 1 1 1 0 X-domain of DnaJ-containing GoLoco PF02188.15 MSTRG.18988.4_2 - 1.2e-08 34.1 0.1 2.6e-08 33.1 0.1 1.6 1 0 0 1 1 1 1 GoLoco motif RGS12_usC PF16612.3 MSTRG.18988.4_2 - 3.6e-08 33.8 0.6 3.6e-08 33.8 0.6 2.1 2 0 0 2 2 2 1 C-terminal unstructured region of RGS12 UPF0239 PF06783.9 MSTRG.18988.4_2 - 0.026 14.6 0.2 0.063 13.4 0.2 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) RGS12_us1 PF16613.3 MSTRG.18988.4_3 - 2e-48 163.4 12.1 2e-48 163.4 12.1 2.1 3 0 0 3 3 3 1 Unstructured region of RGS12 RGS PF00615.17 MSTRG.18988.4_3 - 4.7e-27 94.5 4.8 7.3e-27 93.9 4.8 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain RBD PF02196.13 MSTRG.18988.4_3 - 1.5e-25 89.0 0.4 4.4e-16 58.6 0.1 2.4 2 0 0 2 2 2 2 Raf-like Ras-binding domain TUG-UBL1 PF11470.6 MSTRG.18988.4_3 - 0.13 12.4 0.0 0.38 10.9 0.0 1.7 1 0 0 1 1 1 0 TUG ubiquitin-like domain LRR_8 PF13855.4 MSTRG.17678.1_2 - 3.8e-16 58.5 20.5 7.5e-08 31.9 2.7 4.1 4 0 0 4 4 4 3 Leucine rich repeat LRR_4 PF12799.5 MSTRG.17678.1_2 - 2.9e-10 40.1 16.3 0.0005 20.3 1.8 4.1 3 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 MSTRG.17678.1_2 - 0.00087 19.0 2.3 12 6.1 0.1 5.5 5 0 0 5 5 5 1 Leucine Rich repeat LRR_1 PF00560.31 MSTRG.17678.1_2 - 0.0074 16.5 12.3 5 7.9 1.3 6.1 5 1 0 5 5 5 2 Leucine Rich Repeat LRR_9 PF14580.4 MSTRG.17678.1_2 - 0.0083 15.5 2.1 0.02 14.2 1.4 1.8 1 1 1 2 2 2 1 Leucine-rich repeat Brix PF04427.16 MSTRG.16487.2_3 - 2.3e-45 154.9 0.1 3.8e-45 154.2 0.1 1.4 1 0 0 1 1 1 1 Brix domain PhoLip_ATPase_N PF16209.3 MSTRG.4957.2_3 - 1.7e-14 53.2 3.5 2.2e-14 52.8 3.5 1.1 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Pyridoxal_deC PF00282.17 MSTRG.25383.2_3 - 2.3e-140 467.4 0.0 2.9e-140 467.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.17 MSTRG.25383.2_3 - 0.00078 18.4 0.0 0.0022 16.9 0.0 1.6 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.19 MSTRG.25383.2_3 - 0.0011 18.2 0.0 0.0018 17.4 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase SepSecS PF05889.11 MSTRG.25383.2_3 - 0.0081 14.7 0.0 0.014 13.9 0.0 1.3 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Apolipoprotein PF01442.16 MSTRG.23351.1_1 - 1.4e-29 103.3 17.3 2.3e-29 102.6 17.3 1.3 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain SF-assemblin PF06705.9 MSTRG.23351.1_1 - 0.0022 17.2 6.0 0.0038 16.5 6.0 1.3 1 0 0 1 1 1 1 SF-assemblin/beta giardin MukF_M PF17192.2 MSTRG.23351.1_1 - 0.0025 17.4 3.6 0.0048 16.5 3.6 1.4 1 0 0 1 1 1 1 MukF middle domain Baculo_PEP_C PF04513.10 MSTRG.23351.1_1 - 0.0027 17.6 8.1 0.024 14.5 0.5 2.5 1 1 1 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus ApoLp-III PF07464.9 MSTRG.23351.1_1 - 0.014 15.4 11.0 0.94 9.4 0.2 2.3 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Apo-CIII PF05778.10 MSTRG.23351.1_1 - 0.044 13.3 0.4 0.13 11.7 0.2 1.8 2 0 0 2 2 2 0 Apolipoprotein CIII (Apo-CIII) YtxH PF12732.5 MSTRG.23351.1_1 - 0.051 14.0 7.3 14 6.2 4.8 3.5 2 1 0 2 2 1 0 YtxH-like protein DUF883 PF05957.11 MSTRG.23351.1_1 - 0.071 13.6 7.3 25 5.4 0.3 3.5 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) DUF2884 PF11101.6 MSTRG.23351.1_1 - 0.092 12.1 10.1 0.14 11.5 10.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2884) Toxin_trans PF07952.10 MSTRG.23351.1_1 - 0.15 11.0 0.7 0.26 10.2 0.7 1.3 1 0 0 1 1 1 0 Clostridium neurotoxin, Translocation domain ApoO PF09769.7 MSTRG.23351.1_1 - 0.3 10.9 3.9 10 5.9 0.3 3.5 2 1 2 4 4 3 0 Apolipoprotein O ApoA-II PF04711.11 MSTRG.23351.1_1 - 0.64 10.1 4.7 18 5.5 0.3 3.4 2 1 1 3 3 3 0 Apolipoprotein A-II (ApoA-II) Gp-FAR-1 PF05823.10 MSTRG.23351.1_1 - 1.9 8.7 6.5 5.6 7.1 0.9 2.4 1 1 1 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Fzo_mitofusin PF04799.11 MSTRG.23351.1_1 - 2.3 7.6 11.1 2.9 7.2 4.6 2.4 1 1 1 2 2 2 0 fzo-like conserved region Tup_N PF08581.8 MSTRG.23351.1_1 - 2.5 8.3 7.2 1.1 9.4 4.1 2.0 1 1 1 2 2 2 0 Tup N-terminal ZYG-11_interact PF05884.10 MSTRG.23351.1_1 - 3.9 6.7 5.6 0.92 8.7 0.8 1.9 1 1 1 2 2 2 0 Interactor of ZYG-11 Tweety PF04906.11 MSTRG.23351.1_1 - 5.6 5.4 6.6 0.74 8.3 0.7 2.0 1 1 1 2 2 2 0 Tweety RhoGAP PF00620.25 MSTRG.13867.2_3 - 3.2e-45 153.5 0.0 8.7e-45 152.1 0.0 1.8 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.21 MSTRG.13867.2_3 - 1.4e-16 60.4 3.8 2.3e-16 59.7 2.6 2.1 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.26 MSTRG.13867.2_3 - 8.7e-10 37.9 0.0 1.7e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.13867.2_3 - 2.6e-09 36.6 0.0 5.4e-09 35.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.13867.2_3 - 1.4e-08 34.1 0.0 2.9e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain FlaC_arch PF05377.9 MSTRG.13867.2_3 - 0.15 12.4 2.0 0.62 10.4 2.0 2.1 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF2987 PF11205.6 MSTRG.13867.2_3 - 4.4 7.1 7.0 1.6 8.5 1.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2987) Vitellogenin_N PF01347.20 MSTRG.8359.1_1 - 1.4e-47 162.3 0.0 2.8e-47 161.3 0.0 1.4 1 1 0 1 1 1 1 Lipoprotein amino terminal region IP_trans PF02121.16 MSTRG.24695.6_1 - 1.7e-46 158.7 0.2 2.1e-46 158.4 0.2 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein V-set PF07686.15 MSTRG.22475.1_2 - 7.1e-13 48.5 0.0 1.1e-12 47.9 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 MSTRG.22475.1_2 - 0.00062 20.2 0.0 0.0012 19.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 MSTRG.22475.1_2 - 0.033 14.1 0.0 0.056 13.4 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain BBS2_Mid PF14783.4 MSTRG.25511.2_3 - 0.0053 16.7 0.0 66 3.5 0.0 4.3 5 0 0 5 5 5 3 Ciliary BBSome complex subunit 2, middle region CUB PF00431.18 MSTRG.21221.1_3 - 2.5e-07 30.9 0.0 3.2e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 CUB domain Caveolin PF01146.15 MSTRG.22567.1_3 - 2.9e-57 192.2 2.9 4.7e-57 191.5 2.9 1.3 1 0 0 1 1 1 1 Caveolin SARAF PF06682.10 MSTRG.20976.1_1 - 0.093 12.3 1.5 0.1 12.2 1.5 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis SR-25 PF10500.7 MSTRG.20976.1_1 - 0.79 9.2 13.6 1.5 8.2 13.6 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein API5 PF05918.9 MSTRG.22494.1_3 - 3.3e-199 662.9 0.0 4e-199 662.6 0.0 1.0 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) HEAT_2 PF13646.4 MSTRG.22494.1_3 - 0.019 15.2 0.1 0.066 13.5 0.1 1.9 2 0 0 2 2 2 0 HEAT repeats CHCH PF06747.11 MSTRG.16957.1_2 - 3.7e-05 23.6 5.9 6.6e-05 22.8 5.9 1.4 1 0 0 1 1 1 1 CHCH domain CAP_N PF01213.17 MSTRG.16957.1_2 - 0.53 9.6 5.0 0.88 8.9 5.0 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PTB PF08416.11 MSTRG.24798.5_3 - 7.1e-33 113.4 0.0 1.2e-32 112.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotyrosine-binding domain SH2 PF00017.22 MSTRG.24798.5_3 - 3.3e-08 33.3 0.0 7.1e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 SH2 domain ANF_receptor PF01094.26 MSTRG.3876.1_2 - 3.6e-05 22.9 0.0 4.8e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Tetraspannin PF00335.18 MSTRG.5957.1_2 - 7.9e-45 153.1 12.6 1.1e-44 152.6 12.6 1.2 1 0 0 1 1 1 1 Tetraspanin family RabGAP-TBC PF00566.16 MSTRG.21486.5_2 - 2.3e-54 184.2 2.7 2.3e-54 184.2 2.7 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain bZIP_1 PF00170.19 MSTRG.21486.5_2 - 0.009 16.0 4.3 0.009 16.0 4.3 6.0 7 3 1 8 8 8 1 bZIP transcription factor Hemopexin PF00045.17 MSTRG.16985.1_2 - 2e-41 139.5 9.5 2.1e-12 46.7 0.1 4.8 4 0 0 4 4 4 4 Hemopexin Somatomedin_B PF01033.15 MSTRG.16985.1_2 - 3.5e-10 40.0 15.0 1e-09 38.5 15.0 1.8 1 0 0 1 1 1 1 Somatomedin B domain Neur_chan_LBD PF02931.21 MSTRG.9539.1_2 - 1.7e-49 168.1 0.3 2.3e-49 167.6 0.3 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 MSTRG.9539.1_2 - 4.9e-40 137.9 8.5 3e-36 125.5 8.5 2.7 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region PINIT PF14324.4 MSTRG.26923.2_2 - 1.4e-32 113.0 0.0 2.1e-32 112.4 0.0 1.3 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.18 MSTRG.26923.2_2 - 1.8e-21 75.5 5.0 1.8e-21 75.5 5.0 2.0 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-Nse PF11789.6 MSTRG.26923.2_2 - 0.00014 21.5 1.2 0.00027 20.6 1.2 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-Sec23_Sec24 PF04810.13 MSTRG.26923.2_2 - 0.36 10.8 5.2 0.97 9.4 1.4 2.9 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger PHD PF00628.27 MSTRG.26923.2_2 - 2.9 7.7 8.3 0.59 9.9 2.2 2.7 2 0 0 2 2 2 0 PHD-finger RRM_1 PF00076.20 MSTRG.11413.7_3 - 5.3e-39 131.7 0.3 8.4e-15 54.2 0.0 4.2 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.11413.7_3 - 7.1e-05 22.7 0.1 0.13 12.3 0.0 3.1 3 0 0 3 3 3 2 RNA recognition motif RRM_5 PF13893.4 MSTRG.11413.7_3 - 9.1e-05 21.9 0.0 0.012 15.0 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.6 MSTRG.11413.7_3 - 0.001 18.9 0.0 0.018 14.9 0.0 2.6 3 0 0 3 3 3 1 Limkain b1 ERp29 PF07749.10 MSTRG.11413.7_3 - 0.1 13.3 0.0 0.22 12.3 0.0 1.4 1 0 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain Nup35_RRM_2 PF14605.4 MSTRG.11413.7_3 - 0.4 10.6 1.8 6.6 6.7 0.0 2.8 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif EF-hand_1 PF00036.30 MSTRG.13751.1_3 - 7.9e-11 40.6 2.5 1e-05 24.6 1.1 3.7 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 MSTRG.13751.1_3 - 7.1e-10 37.9 1.9 3.6e-06 26.3 0.7 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.4 MSTRG.13751.1_3 - 1.7e-08 34.6 0.3 0.00027 21.2 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 MSTRG.13751.1_3 - 3.4e-05 23.4 0.7 0.44 10.2 0.2 3.9 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.4 MSTRG.13751.1_3 - 0.0056 16.0 1.5 0.0056 16.0 1.5 2.3 2 0 0 2 2 2 1 EF hand Caleosin PF05042.11 MSTRG.13751.1_3 - 0.033 14.0 0.0 6.3 6.6 0.0 2.4 2 1 0 2 2 2 0 Caleosin related protein BTB PF00651.29 MSTRG.18670.2_2 - 7e-24 84.1 0.0 1.3e-23 83.2 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BEN PF10523.7 MSTRG.18670.2_2 - 1.4e-07 31.5 0.0 3.3e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 BEN domain GLE1 PF07817.11 MSTRG.26835.1_1 - 1.9e-79 266.3 0.0 4.7e-79 265.0 0.0 1.7 1 1 0 1 1 1 1 GLE1-like protein DUF1967 PF09269.9 MSTRG.26835.1_1 - 0.016 15.0 2.3 0.022 14.6 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1967) DUF4288 PF14119.4 MSTRG.26835.1_1 - 0.07 13.4 5.1 0.22 11.8 5.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4288) Ank_4 PF13637.4 MSTRG.2924.1_1 - 3.3e-19 68.9 0.2 5.5e-06 26.7 0.0 5.1 5 0 0 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.4 MSTRG.2924.1_1 - 1.1e-12 47.8 4.6 0.00081 19.6 0.0 5.0 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.2924.1_1 - 3.2e-12 45.4 0.3 0.0002 21.4 0.0 5.8 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.28 MSTRG.2924.1_1 - 1.1e-11 44.5 2.1 0.0006 20.0 0.0 5.3 5 0 0 5 5 5 3 Ankyrin repeat Ank_2 PF12796.5 MSTRG.2924.1_1 - 3e-11 43.6 0.2 1.3e-05 25.6 0.0 3.0 2 1 0 3 3 3 2 Ankyrin repeats (3 copies) SOCS_box PF07525.14 MSTRG.2924.1_1 - 1.9e-08 34.4 0.7 5.5e-08 32.9 0.7 1.9 1 0 0 1 1 1 1 SOCS box Glyco_transf_49 PF13896.4 MSTRG.25692.1_1 - 4.3e-23 82.1 1.0 6.6e-12 45.3 0.0 2.5 1 1 1 2 2 2 2 Glycosyl-transferase for dystroglycan Glyco_transf_8 PF01501.18 MSTRG.25692.1_1 - 7.1e-19 68.2 0.1 1e-18 67.7 0.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 8 UPF0184 PF03670.11 MSTRG.25692.1_1 - 0.22 11.8 1.6 0.43 10.9 1.6 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) EP400_N PF15790.3 MSTRG.2941.1_1 - 5.9e-271 899.3 41.7 5.9e-271 899.3 41.7 6.3 4 2 1 6 6 6 1 E1A-binding protein p400, N-terminal SNF2_N PF00176.21 MSTRG.2941.1_1 - 3.6e-50 170.5 5.6 9.5e-50 169.1 5.6 1.7 1 0 0 1 1 1 1 SNF2 family N-terminal domain HSA PF07529.11 MSTRG.2941.1_1 - 6.5e-19 67.9 9.4 6.5e-19 67.9 9.4 3.4 2 0 0 2 2 2 1 HSA Helicase_C PF00271.29 MSTRG.2941.1_1 - 9.1e-08 32.3 0.1 6.1e-07 29.7 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.2941.1_1 - 6.9e-05 22.8 0.0 0.00034 20.5 0.0 2.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.6 MSTRG.2941.1_1 - 0.00049 19.2 4.9 0.005 15.9 0.1 3.0 3 0 0 3 3 3 2 Class II histone deacetylase complex subunits 2 and 3 Myb_DNA-bind_4 PF13837.4 MSTRG.2941.1_1 - 0.00051 20.3 2.1 0.0018 18.5 0.0 2.9 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Myb_DNA-binding PF00249.29 MSTRG.2941.1_1 - 0.0011 19.0 0.0 0.0029 17.6 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 MSTRG.2941.1_1 - 0.0013 18.8 0.1 0.0064 16.6 0.1 2.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Ntox24 PF15529.4 MSTRG.22791.1_1 - 0.055 13.7 0.5 11 6.3 0.1 3.2 3 0 0 3 3 3 0 Bacterial toxin 24 TIP49 PF06068.11 MSTRG.22791.1_2 - 9.2e-184 610.8 2.6 1.1e-183 610.5 2.6 1.1 1 0 0 1 1 1 1 TIP49 C-terminus AAA PF00004.27 MSTRG.22791.1_2 - 3.7e-09 37.0 0.7 5.4e-06 26.7 0.1 2.8 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.13 MSTRG.22791.1_2 - 2e-06 27.2 0.8 3.5e-06 26.4 0.1 1.7 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain RuvB_N PF05496.10 MSTRG.22791.1_2 - 2.2e-06 27.0 0.7 0.001 18.3 0.0 2.7 3 0 0 3 3 3 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.4 MSTRG.22791.1_2 - 3.7e-06 27.3 0.1 8.5e-05 22.8 0.1 2.7 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.4 MSTRG.22791.1_2 - 3.9e-05 23.8 0.4 0.073 13.2 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_5 PF07728.12 MSTRG.22791.1_2 - 8.4e-05 22.5 0.1 0.053 13.4 0.0 3.0 2 1 1 3 3 3 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.24 MSTRG.22791.1_2 - 0.00045 19.8 0.1 0.25 10.9 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain ATPase PF06745.11 MSTRG.22791.1_2 - 0.00069 18.9 0.1 0.0014 17.8 0.1 1.4 1 0 0 1 1 1 1 KaiC Mg_chelatase PF01078.19 MSTRG.22791.1_2 - 0.00074 18.8 0.7 0.025 13.8 0.2 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.4 MSTRG.22791.1_2 - 0.0016 18.6 5.0 0.0023 18.1 1.9 2.5 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.4 MSTRG.22791.1_2 - 0.0018 17.7 0.0 0.0059 16.1 0.1 1.7 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.10 MSTRG.22791.1_2 - 0.0037 16.5 0.3 0.0069 15.6 0.3 1.4 1 0 0 1 1 1 1 Zeta toxin DUF2075 PF09848.7 MSTRG.22791.1_2 - 0.0084 15.2 0.1 0.018 14.1 0.0 1.6 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) NACHT PF05729.10 MSTRG.22791.1_2 - 0.012 15.3 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_17 PF13207.4 MSTRG.22791.1_2 - 0.052 13.8 0.3 0.13 12.6 0.3 1.7 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.4 MSTRG.22791.1_2 - 0.11 12.1 0.2 0.24 11.0 0.2 1.7 1 1 0 1 1 1 0 AAA domain PhoH PF02562.14 MSTRG.22791.1_2 - 0.17 11.2 2.3 1.1 8.6 0.2 2.7 3 0 0 3 3 3 0 PhoH-like protein BAALC_N PF06989.10 MSTRG.29149.1_3 - 1.9e-24 85.6 0.8 3.7e-24 84.7 0.8 1.5 1 0 0 1 1 1 1 BAALC N-terminus PAP2 PF01569.19 MSTRG.8903.4_2 - 5.4e-26 90.9 2.6 1.3e-25 89.6 2.6 1.7 1 0 0 1 1 1 1 PAP2 superfamily 7TM_GPCR_Srsx PF10320.7 MSTRG.8903.4_2 - 0.017 14.4 1.6 0.19 11.0 0.1 2.2 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srsx PAP2_C PF14360.4 MSTRG.8903.4_2 - 0.032 14.6 2.7 0.032 14.6 2.7 2.6 2 0 0 2 2 2 0 PAP2 superfamily C-terminal DUF2976 PF11190.6 MSTRG.8903.4_2 - 0.3 10.8 1.8 0.38 10.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) DUF3504 PF12012.6 MSTRG.13927.1_1 - 4.7e-54 182.5 1.1 1.9e-53 180.5 1.1 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3504) CopK PF11525.6 MSTRG.13927.1_1 - 0.00063 19.2 3.2 4.8 6.8 0.2 4.5 1 1 4 5 5 5 4 Copper resistance protein K Sarcoglycan_1 PF04790.11 MSTRG.13927.1_1 - 0.0032 16.7 9.1 0.026 13.7 4.5 2.3 1 1 1 2 2 2 2 Sarcoglycan complex subunit protein DUF2917 PF11142.6 MSTRG.13927.1_1 - 0.0043 16.3 10.6 2.7 7.3 0.1 5.7 2 2 4 6 6 6 2 Protein of unknown function (DUF2917) DUF2345 PF10106.7 MSTRG.13927.1_1 - 0.0048 16.7 24.2 0.089 12.5 5.1 3.7 2 1 2 4 4 4 3 Uncharacterized protein conserved in bacteria (DUF2345) DUF1498 PF07385.10 MSTRG.13927.1_1 - 0.0053 15.9 9.2 0.43 9.7 0.7 3.6 1 1 3 4 4 4 3 Protein of unknown function (DUF1498) S-layer PF07752.9 MSTRG.13927.1_1 - 0.081 11.8 0.2 47 2.8 0.0 3.0 1 1 2 3 3 3 0 S-layer protein GRP PF07172.9 MSTRG.1898.1_2 - 0.00019 21.9 7.4 0.00031 21.2 7.4 1.2 1 0 0 1 1 1 1 Glycine rich protein family GST_C PF00043.23 MSTRG.762.1_2 - 2.6e-05 24.2 0.0 3.3e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 MSTRG.762.1_2 - 5e-05 23.3 0.0 6e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 MSTRG.762.1_2 - 9.6e-05 22.1 0.0 0.00032 20.4 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain dsrm PF00035.24 MSTRG.22933.1_1 - 7e-25 87.4 0.7 1.9e-11 44.3 0.1 3.3 3 0 0 3 3 3 2 Double-stranded RNA binding motif DND1_DSRM PF14709.5 MSTRG.22933.1_1 - 6.9e-09 35.7 7.2 1.2e-07 31.7 0.7 4.2 3 2 0 3 3 3 1 double strand RNA binding domain from DEAD END PROTEIN 1 Staufen_C PF16482.3 MSTRG.22933.1_1 - 4.8e-08 33.0 0.2 7.2e-07 29.2 0.1 2.5 2 1 0 2 2 2 1 Staufen C-terminal domain Dynamin_M PF01031.18 MSTRG.28522.1_3 - 4.2e-23 81.9 0.0 4.5e-23 81.7 0.0 1.0 1 0 0 1 1 1 1 Dynamin central region FH2 PF02181.21 MSTRG.16426.1_2 - 1.2e-114 383.2 3.9 2.2e-114 382.3 3.9 1.4 1 0 0 1 1 1 1 Formin Homology 2 Domain Adaptin_binding PF10199.7 MSTRG.16426.1_2 - 0.91 10.0 13.2 0.85 10.1 4.0 2.5 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 ARA70 PF12489.6 MSTRG.26264.3_2 - 4.3e-33 114.2 12.5 8.7e-17 61.4 3.1 3.6 3 1 1 4 4 4 2 Nuclear coactivator Trns_repr_metal PF02583.15 MSTRG.26264.3_2 - 0.11 12.8 0.0 0.27 11.5 0.0 1.7 1 0 0 1 1 1 0 Metal-sensitive transcriptional repressor zf-U11-48K PF05253.10 MSTRG.3537.1_1 - 3.9e-07 29.7 0.4 8e-07 28.7 0.4 1.6 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger SRP-alpha_N PF04086.11 MSTRG.3537.1_1 - 7.7 6.2 25.8 12 5.6 25.8 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal zf-BED PF02892.13 MSTRG.16568.1_1 - 0.091 12.7 2.1 0.21 11.6 2.1 1.6 1 0 0 1 1 1 0 BED zinc finger Urm1 PF09138.9 MSTRG.8624.1_1 - 2e-36 124.1 0.0 3.1e-36 123.5 0.0 1.3 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.18 MSTRG.8624.1_1 - 0.022 15.2 0.0 0.037 14.5 0.0 1.3 1 0 0 1 1 1 0 ThiS family 6PF2K PF01591.16 MSTRG.20181.3_3 - 4.3e-102 340.0 1.6 6.8e-102 339.4 1.6 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.20 MSTRG.20181.3_3 - 5.3e-40 137.1 0.0 7.3e-40 136.6 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.4 MSTRG.20181.3_3 - 1.5e-08 34.8 0.0 2.7e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.8 MSTRG.20181.3_3 - 0.0014 18.0 0.1 0.0023 17.3 0.1 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Zeta_toxin PF06414.10 MSTRG.20181.3_3 - 0.0021 17.3 0.0 0.0043 16.2 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.4 MSTRG.20181.3_3 - 0.17 12.3 0.0 0.53 10.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain Tim44 PF04280.13 MSTRG.13519.1_2 - 2.2e-43 147.7 0.8 4.5e-43 146.7 0.0 1.9 2 0 0 2 2 2 1 Tim44-like domain CREPT PF16566.3 MSTRG.13519.1_2 - 0.22 11.6 3.5 0.45 10.5 3.5 1.5 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour DUF3347 PF11827.6 MSTRG.13519.1_2 - 0.22 11.6 15.9 1.5 8.8 11.3 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3347) Gp-FAR-1 PF05823.10 MSTRG.13519.1_2 - 0.56 10.4 8.7 1.1 9.4 8.7 1.4 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) AIM3 PF17096.3 MSTRG.13519.1_2 - 2.7 8.9 7.5 0.31 11.9 0.6 2.4 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 Dak2 PF02734.15 MSTRG.13519.1_2 - 3.2 7.5 6.8 11 5.7 6.8 1.8 1 1 0 1 1 1 0 DAK2 domain Pentaxin PF00354.15 MSTRG.20748.1_3 - 2.9e-55 186.9 0.0 4.2e-55 186.3 0.0 1.2 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.4 MSTRG.20748.1_3 - 4.3e-11 43.0 0.0 5.6e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Sulfotransfer_1 PF00685.25 MSTRG.20708.1_3 - 2.2e-37 128.9 0.0 2.7e-37 128.6 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 MSTRG.20708.1_3 - 6e-17 62.6 0.0 2.9e-11 44.1 0.0 2.2 1 1 1 2 2 2 2 Sulfotransferase family Sulfotransfer_2 PF03567.12 MSTRG.20708.1_3 - 0.1 12.4 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Sulfotransferase family EF-hand_7 PF13499.4 MSTRG.15756.2_3 - 6.7e-13 48.8 0.2 2.3e-06 27.8 0.0 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 MSTRG.15756.2_3 - 3.1e-11 41.8 0.5 1.2e-06 27.5 0.1 3.1 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.4 MSTRG.15756.2_3 - 1.2e-10 40.9 0.0 8.6e-06 25.3 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 MSTRG.15756.2_3 - 4.2e-10 38.6 0.5 0.00075 19.1 0.1 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.4 MSTRG.15756.2_3 - 2.5e-06 26.6 1.0 0.0003 20.0 0.0 3.0 4 0 0 4 4 4 1 EF hand SPARC_Ca_bdg PF10591.7 MSTRG.15756.2_3 - 0.00087 19.5 0.5 0.0067 16.6 0.1 2.4 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 MSTRG.15756.2_3 - 0.0052 16.6 0.4 0.039 13.8 0.1 2.0 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.4 MSTRG.15756.2_3 - 0.015 15.5 0.0 0.56 10.4 0.0 2.8 2 1 0 2 2 2 0 EF-hand domain His_kinase PF06580.11 MSTRG.15756.2_3 - 0.067 13.4 0.0 0.15 12.2 0.0 1.6 1 1 0 1 1 1 0 Histidine kinase EF-hand_2 PF09068.9 MSTRG.15756.2_3 - 0.07 13.1 0.1 4.2 7.4 0.0 2.4 2 1 0 2 2 2 0 EF hand NAP PF00956.16 MSTRG.22123.1_1 - 1.7e-101 338.8 1.5 1.7e-101 338.8 1.5 1.6 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) RNA_pol_3_Rpc31 PF11705.6 MSTRG.22123.1_1 - 0.011 15.8 10.6 0.011 15.8 10.6 1.7 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Nop14 PF04147.10 MSTRG.22123.1_1 - 0.27 9.3 7.2 0.45 8.5 7.2 1.3 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.11 MSTRG.22123.1_1 - 6.5 4.6 15.3 10 3.9 15.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi ANF_receptor PF01094.26 MSTRG.21026.1_2 - 1.4e-68 231.4 0.3 1.9e-68 231.0 0.3 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 MSTRG.21026.1_2 - 2.1e-27 96.3 22.0 4e-27 95.4 22.0 1.5 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 MSTRG.21026.1_2 - 4.8e-14 51.9 11.2 1.4e-13 50.5 11.2 1.9 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 MSTRG.21026.1_2 - 3.5e-09 36.7 0.2 5.9e-09 36.0 0.2 1.2 1 0 0 1 1 1 1 Periplasmic binding protein Ephrin_rec_like PF07699.11 MSTRG.21026.1_2 - 0.00083 18.9 6.7 0.00083 18.9 6.7 2.4 2 1 0 2 2 2 1 Putative ephrin-receptor like PMP22_Claudin PF00822.18 MSTRG.27120.1_2 - 1.6e-28 99.6 11.4 2.7e-28 98.8 11.4 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 MSTRG.27120.1_2 - 0.00066 19.3 16.2 0.0028 17.3 13.2 2.4 1 1 1 2 2 2 2 PMP-22/EMP/MP20/Claudin tight junction DUF1129 PF06570.9 MSTRG.27120.1_2 - 0.15 11.4 1.9 0.23 10.8 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Chitin_synth_2 PF03142.13 MSTRG.23199.1_2 - 4.6e-24 84.8 2.9 1e-20 73.8 0.1 2.7 1 1 1 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.4 MSTRG.23199.1_2 - 2.8e-12 46.8 5.4 1e-11 45.0 3.5 3.0 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.4 MSTRG.23199.1_2 - 1.2e-07 31.7 0.1 2.3e-07 30.8 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 DUF3246 PF11596.6 MSTRG.23199.1_2 - 0.051 12.9 1.3 0.092 12.0 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Exonuc_VII_L PF02601.13 MSTRG.23199.1_2 - 0.075 12.4 3.4 0.17 11.3 3.4 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit Cas_APE2256 PF09651.8 MSTRG.23199.1_2 - 0.1 12.3 0.2 0.3 10.8 0.2 1.7 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_APE2256) Anemone_cytotox PF06369.10 MSTRG.10188.1_3 - 9.1e-15 54.6 0.1 1.3e-14 54.1 0.1 1.2 1 0 0 1 1 1 1 Sea anemone cytotoxic protein zf-H2C2_2 PF13465.4 MSTRG.16186.2_1 - 3.7e-57 188.2 62.6 1.8e-09 37.4 0.6 9.5 9 0 0 9 9 9 9 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.16186.2_1 - 1e-28 98.0 80.1 6.3e-05 23.1 1.9 9.7 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.16186.2_1 - 1.3e-20 72.2 83.2 0.0058 17.2 0.1 10.4 10 0 0 10 10 10 8 C2H2-type zinc finger zf-met PF12874.5 MSTRG.16186.2_1 - 0.0095 16.2 72.1 0.012 15.9 2.7 8.8 9 0 0 9 9 9 6 Zinc-finger of C2H2 type LIM PF00412.20 MSTRG.16186.2_1 - 0.038 14.1 47.4 6.2 7.0 0.2 7.7 3 1 5 8 8 8 0 LIM domain BolA PF01722.16 MSTRG.16186.2_1 - 0.16 12.2 19.6 13 6.0 3.3 5.6 1 1 2 3 3 3 0 BolA-like protein GAGA PF09237.9 MSTRG.16186.2_1 - 0.74 9.5 19.5 2.5 7.8 0.4 5.2 1 1 3 5 5 5 0 GAGA factor C1_4 PF07975.10 MSTRG.16186.2_1 - 1.6 8.9 41.8 2 8.6 2.4 5.7 5 1 0 5 5 5 0 TFIIH C1-like domain zf-C2H2_2 PF12756.5 MSTRG.16186.2_1 - 2.8 8.2 46.8 9.9 6.4 0.3 7.9 1 1 7 8 8 8 0 C2H2 type zinc-finger (2 copies) GETHR PF05671.9 MSTRG.16186.2_3 - 0.042 13.1 4.5 2.2 7.6 0.2 3.7 3 0 0 3 3 3 0 GETHR pentapeptide repeat (5 copies) UDPGT PF00201.16 MSTRG.14838.1_3 - 6.9e-109 364.8 0.7 8.2e-109 364.5 0.7 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 MSTRG.14838.1_3 - 6.5e-06 26.1 0.0 9.4e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain DUF4312 PF14189.4 MSTRG.14838.1_3 - 0.099 12.5 0.0 0.099 12.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4312) Pro_3_hydrox_C PF05373.9 MSTRG.14838.1_3 - 0.15 12.0 0.1 0.24 11.4 0.1 1.2 1 0 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal TNFR_c6 PF00020.16 MSTRG.23376.1_3 - 2.6e-21 75.6 26.9 1.5e-09 37.9 6.8 4.6 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region Death PF00531.20 MSTRG.23376.1_3 - 1.1e-08 34.9 0.2 2.1e-08 34.1 0.2 1.4 1 0 0 1 1 1 1 Death domain Ephrin_rec_like PF07699.11 MSTRG.23376.1_3 - 0.00012 21.7 27.9 0.4 10.3 2.8 4.5 1 1 3 4 4 4 4 Putative ephrin-receptor like NCD3G PF07562.12 MSTRG.23376.1_3 - 1.3 9.0 21.6 1.3 8.9 8.2 3.4 1 1 2 3 3 3 0 Nine Cysteines Domain of family 3 GPCR BRF1 PF07741.11 MSTRG.1278.1_2 - 1.7e-27 95.6 9.2 3.1e-27 94.7 9.2 1.5 1 0 0 1 1 1 1 Brf1-like TBP-binding domain CTF_NFI PF00859.16 MSTRG.27879.5_1 - 9.2e-80 268.6 14.8 9.2e-80 268.6 14.8 3.1 3 1 0 3 3 3 2 CTF/NF-I family transcription modulation region NfI_DNAbd_pre-N PF10524.7 MSTRG.27879.5_1 - 1.9e-27 94.8 2.9 3.3e-27 94.0 2.9 1.4 1 0 0 1 1 1 1 Nuclear factor I protein pre-N-terminus MH1 PF03165.14 MSTRG.27879.5_1 - 3.4e-10 39.9 0.1 7.2e-10 38.9 0.1 1.6 1 0 0 1 1 1 1 MH1 domain CTF_NFI PF00859.16 MSTRG.27879.5_3 - 4.5e-05 23.4 0.1 6.4e-05 22.9 0.1 1.2 1 0 0 1 1 1 1 CTF/NF-I family transcription modulation region Abi PF02517.14 MSTRG.8145.1_2 - 8.3e-15 54.8 4.7 8.3e-15 54.8 4.7 2.2 3 0 0 3 3 3 1 CAAX protease self-immunity RRM_1 PF00076.20 MSTRG.13435.1_1 - 6.4e-18 64.2 0.0 1.1e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) THOC2_N PF16134.3 MSTRG.13435.1_1 - 0.38 9.2 1.6 0.52 8.7 1.6 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus MTBP_C PF14920.4 MSTRG.9138.1_2 - 1.4e-109 365.6 13.1 1.8e-109 365.3 13.1 1.1 1 0 0 1 1 1 1 MDM2-binding MTBP_mid PF14919.4 MSTRG.9138.1_2 - 7.9e-19 67.9 0.1 7.9e-19 67.9 0.1 1.7 2 0 0 2 2 2 1 MDM2-binding NAM-associated PF14303.4 MSTRG.9138.1_2 - 0.0054 17.3 7.4 0.0082 16.7 7.4 1.4 1 0 0 1 1 1 1 No apical meristem-associated C-terminal domain SR-25 PF10500.7 MSTRG.9138.1_2 - 0.016 14.7 18.6 0.025 14.0 18.6 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Macoilin PF09726.7 MSTRG.9138.1_2 - 1.1 7.6 12.5 1.7 7.0 12.5 1.2 1 0 0 1 1 1 0 Transmembrane protein FixP_N PF14715.4 MSTRG.9138.1_3 - 0.51 10.0 2.3 1 9.0 2.3 1.5 1 0 0 1 1 1 0 N-terminal domain of cytochrome oxidase-cbb3, FixP Integrin_beta PF00362.16 MSTRG.21334.2_1 - 2.7e-115 384.2 0.2 3.9e-115 383.6 0.2 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain PSI_integrin PF17205.1 MSTRG.21334.2_1 - 2.1e-12 46.6 9.2 2.1e-12 46.6 9.2 2.8 3 0 0 3 3 3 1 Integrin plexin domain EGF_2 PF07974.11 MSTRG.21334.2_1 - 0.0075 16.5 11.7 0.0075 16.5 11.7 5.4 5 2 0 5 5 5 1 EGF-like domain LCAT PF02450.13 MSTRG.22031.1_1 - 2.2e-100 336.5 1.3 2.2e-99 333.1 1.3 1.9 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.6 MSTRG.22031.1_1 - 3.4e-05 23.1 0.0 5.6e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF1749 PF08538.8 MSTRG.22031.1_1 - 0.0015 17.6 0.0 0.0027 16.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.5 MSTRG.22031.1_1 - 0.003 18.1 0.0 0.0042 17.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.11 MSTRG.22031.1_1 - 0.0039 16.8 0.2 0.0077 15.8 0.0 1.5 2 0 0 2 2 2 1 PGAP1-like protein LIDHydrolase PF10230.7 MSTRG.22031.1_1 - 0.0089 15.5 0.1 0.068 12.6 0.0 2.0 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase Ser_hydrolase PF06821.11 MSTRG.22031.1_1 - 0.016 14.9 0.3 0.034 13.9 0.0 1.6 2 0 0 2 2 2 0 Serine hydrolase DUF915 PF06028.9 MSTRG.22031.1_1 - 0.022 14.0 0.1 0.042 13.0 0.1 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Esterase PF00756.18 MSTRG.22031.1_1 - 0.024 14.1 0.0 0.036 13.6 0.0 1.2 1 0 0 1 1 1 0 Putative esterase Abhydrolase_1 PF00561.18 MSTRG.22031.1_1 - 0.071 12.6 0.0 0.17 11.4 0.0 1.6 2 0 0 2 2 2 0 alpha/beta hydrolase fold DUF1350 PF07082.9 MSTRG.22031.1_1 - 0.1 11.7 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1350) UPF0020 PF01170.16 MSTRG.13997.1_1 - 4.6e-23 81.8 0.0 6.1e-23 81.4 0.0 1.1 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 R3H PF01424.20 MSTRG.9403.1_1 - 9.5e-13 47.8 0.1 2.1e-12 46.7 0.1 1.6 1 0 0 1 1 1 1 R3H domain IF4E PF01652.16 MSTRG.6543.1_1 - 0.022 14.4 0.0 0.029 14.0 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic initiation factor 4E G-alpha PF00503.18 MSTRG.15672.1_3 - 7.3e-107 357.4 2.1 9.3e-107 357.1 2.1 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 MSTRG.15672.1_3 - 3.9e-15 55.6 2.5 4.1e-12 45.8 0.4 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 MSTRG.15672.1_3 - 0.00057 19.2 1.2 0.015 14.6 0.1 2.3 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Roc PF08477.11 MSTRG.15672.1_3 - 0.00083 19.4 1.1 0.26 11.4 0.1 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.25 MSTRG.15672.1_3 - 0.023 14.1 0.0 1.5 8.2 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain TniB PF05621.9 MSTRG.15672.1_3 - 0.062 12.4 0.5 0.099 11.7 0.5 1.2 1 0 0 1 1 1 0 Bacterial TniB protein AAA_29 PF13555.4 MSTRG.15672.1_3 - 0.15 11.7 0.0 0.36 10.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Tweety PF04906.11 MSTRG.4843.1_2 - 3.3e-167 556.1 14.0 1.3e-143 478.4 7.7 2.0 2 0 0 2 2 2 2 Tweety DUF4131 PF13567.4 MSTRG.4843.1_2 - 0.025 14.0 5.0 1.2 8.6 4.4 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4131) DGF-1_C PF11040.6 MSTRG.4843.1_2 - 0.077 12.9 0.5 0.64 9.9 0.2 2.3 2 0 0 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Glucos_trans_II PF14264.4 MSTRG.4843.1_2 - 0.11 11.6 6.1 0.031 13.5 0.4 2.4 3 0 0 3 3 3 0 Glucosyl transferase GtrII SUR7 PF06687.10 MSTRG.4843.1_2 - 0.29 10.6 8.3 1.9 7.9 1.7 2.9 3 0 0 3 3 3 0 SUR7/PalI family Tetraspannin PF00335.18 MSTRG.4843.1_2 - 1.5 8.5 22.0 0.6 9.8 0.3 2.4 2 1 0 2 2 2 0 Tetraspanin family GRAM PF02893.18 MSTRG.10552.2_3 - 1.6e-21 76.1 0.2 5.2e-21 74.5 0.0 1.8 1 1 1 2 2 2 1 GRAM domain DUF2616 PF11077.6 MSTRG.22685.3_1 - 0.012 15.2 0.7 0.016 14.8 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2616) Tmp39 PF10271.7 MSTRG.17741.1_3 - 8.2e-201 667.5 20.5 1e-200 667.2 20.5 1.0 1 0 0 1 1 1 1 Putative transmembrane protein DUF1830 PF08865.9 MSTRG.23877.2_1 - 0.16 11.8 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1830) Myosin_head PF00063.19 MSTRG.7084.1_1 - 2.3e-284 944.7 1.4 2.7e-284 944.5 1.4 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_N PF02736.17 MSTRG.7084.1_1 - 9e-13 47.7 3.9 1.8e-12 46.7 3.9 1.5 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain AAA_22 PF13401.4 MSTRG.7084.1_1 - 0.0075 16.4 0.0 0.042 14.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.4 MSTRG.7084.1_1 - 0.034 14.4 0.0 0.082 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.25 MSTRG.7084.1_1 - 0.16 12.4 0.5 11 6.3 0.0 3.0 3 1 0 3 3 3 0 ABC transporter Gpi16 PF04113.12 MSTRG.18228.3_2 - 7.6e-23 80.6 0.2 1e-22 80.2 0.2 1.1 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component Gpi16 PF04113.12 MSTRG.18228.3_3 - 7.6e-122 407.5 0.1 1.4e-120 403.2 0.1 2.0 1 1 0 1 1 1 1 Gpi16 subunit, GPI transamidase component Vps8 PF12816.5 MSTRG.14551.1_2 - 8e-54 182.0 0.1 1.3e-53 181.3 0.1 1.3 1 0 0 1 1 1 1 Golgi CORVET complex core vacuolar protein 8 ANAPC4_WD40 PF12894.5 MSTRG.14551.1_2 - 0.0032 17.6 0.1 1.3 9.2 0.0 3.7 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 MSTRG.14551.1_2 - 0.15 12.9 2.7 25 5.8 0.0 4.2 3 1 0 3 3 3 0 WD domain, G-beta repeat PQQ_2 PF13360.4 MSTRG.14551.1_2 - 0.17 11.3 0.0 0.49 9.8 0.0 1.8 2 0 0 2 2 2 0 PQQ-like domain Syja_N PF02383.16 MSTRG.14739.1_2 - 4.8e-94 315.0 0.1 7.2e-94 314.4 0.1 1.3 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.6 MSTRG.14739.1_2 - 5.5e-22 77.5 0.1 1.5e-21 76.1 0.0 1.7 2 0 0 2 2 2 1 Inositol phosphatase BAF250_C PF12031.6 MSTRG.17222.2_3 - 3.6e-110 367.1 0.0 5.7e-110 366.5 0.0 1.3 1 0 0 1 1 1 1 SWI/SNF-like complex subunit BAF250/Osa ARID PF01388.19 MSTRG.17222.2_3 - 3.5e-14 53.1 0.0 7e-14 52.1 0.0 1.6 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain FAM91_C PF14648.4 MSTRG.17222.2_3 - 0.6 8.7 2.2 1.2 7.7 2.2 1.4 1 0 0 1 1 1 0 FAM91 C-terminus Granin PF01271.15 MSTRG.27213.1_3 - 0.00038 19.4 48.1 0.0015 17.4 38.3 3.0 2 1 0 2 2 2 2 Granin (chromogranin or secretogranin) Orthopox_F7 PF05813.10 MSTRG.27213.1_3 - 0.26 11.3 5.9 0.97 9.5 5.9 2.1 1 0 0 1 1 1 0 Orthopoxvirus F7 protein F420_oxidored PF03807.15 MSTRG.9714.2_1 - 8e-18 64.7 0.1 1.4e-17 63.9 0.1 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Ferric_reduct PF01794.17 MSTRG.9714.2_1 - 9e-13 48.3 0.3 9e-13 48.3 0.3 2.8 2 1 1 3 3 3 1 Ferric reductase like transmembrane component 2-Hacid_dh_C PF02826.17 MSTRG.9714.2_1 - 8.2e-07 28.4 0.0 1.7e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.13 MSTRG.9714.2_1 - 8.6e-07 29.1 0.0 1.5e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.18 MSTRG.9714.2_1 - 1.4e-05 25.0 0.0 2.5e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase IlvN PF07991.10 MSTRG.9714.2_1 - 0.00015 21.3 0.0 0.00024 20.6 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain rve PF00665.24 MSTRG.1420.1_3 - 2.8e-17 62.9 0.0 4.4e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Xan_ur_permease PF00860.18 MSTRG.20686.1_2 - 2.3e-87 293.1 20.8 3e-87 292.7 20.8 1.1 1 0 0 1 1 1 1 Permease family ORC2 PF04084.12 MSTRG.4280.3_1 - 2.7e-15 56.0 1.0 1.3e-14 53.8 1.0 1.9 1 1 0 1 1 1 1 Origin recognition complex subunit 2 Arrestin_N PF00339.27 MSTRG.5715.1_1 - 5.8e-23 81.4 0.9 1.1e-19 70.8 0.3 2.4 2 1 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.20 MSTRG.5715.1_1 - 3.6e-19 69.3 2.6 8.6e-19 68.1 0.6 2.2 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Spo0M PF07070.9 MSTRG.5715.1_1 - 0.00034 20.1 0.1 0.005 16.3 0.0 2.5 2 2 0 2 2 2 1 SpoOM protein AbrB-like PF14250.4 MSTRG.5715.1_1 - 0.072 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 AbrB-like transcriptional regulator IP_trans PF02121.16 MSTRG.24695.3_3 - 3.7e-117 390.1 2.5 4.9e-117 389.7 2.5 1.1 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein LIM PF00412.20 MSTRG.14830.1_2 - 4.6e-62 206.0 68.4 2.2e-14 53.3 3.0 6.1 6 0 0 6 6 6 5 LIM domain PMP22_Claudin PF00822.18 MSTRG.27112.1_1 - 2.7e-11 43.5 5.1 3.5e-11 43.1 5.1 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 MSTRG.27112.1_1 - 0.0015 18.1 3.2 0.0031 17.2 3.2 1.5 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction MFS_1 PF07690.14 MSTRG.14576.3_3 - 1.1e-43 149.4 41.0 1.7e-36 125.8 32.0 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 MSTRG.14576.3_3 - 4.8e-08 32.2 2.8 4.8e-08 32.2 2.8 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter DUF2070 PF09843.7 MSTRG.14576.3_3 - 5.6 5.0 10.8 21 3.1 10.2 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2070) Arm PF00514.21 MSTRG.24961.1_3 - 5.4e-16 57.9 9.0 0.00023 20.9 0.0 6.4 6 0 0 6 6 6 4 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.7 MSTRG.24961.1_3 - 0.091 12.7 5.1 5.1 7.1 0.2 4.7 2 2 3 5 5 5 0 Spinocerebellar ataxia type 10 protein domain Caveolin PF01146.15 MSTRG.22566.1_3 - 7.9e-49 164.9 0.3 1.2e-48 164.3 0.3 1.3 1 0 0 1 1 1 1 Caveolin Med7 PF05983.9 MSTRG.16027.1_2 - 2.9e-45 154.5 7.6 7.6e-45 153.1 7.6 1.7 1 1 0 1 1 1 1 MED7 protein Katanin_con80 PF13925.4 MSTRG.16027.1_2 - 0.026 14.4 0.6 0.042 13.7 0.6 1.2 1 0 0 1 1 1 0 con80 domain of Katanin EKLF_TAD2 PF16833.3 MSTRG.21262.1_2 - 0.073 13.0 0.1 0.16 11.9 0.1 1.5 1 0 0 1 1 1 0 Erythroid krueppel-like transcription factor, transactivation 2 Peptidase_S10 PF00450.20 MSTRG.13657.2_2 - 1.6e-128 429.6 0.0 1.8e-128 429.4 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Ndc1_Nup PF09531.8 MSTRG.24865.2_3 - 1.5e-120 403.6 9.6 1.8e-120 403.4 9.6 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup BRCT_2 PF16589.3 MSTRG.7655.1_1 - 3.6e-20 72.0 0.1 1.3e-05 25.3 0.0 3.5 3 0 0 3 3 3 3 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.5 MSTRG.7655.1_1 - 3.9e-16 58.6 5.6 1.1e-13 50.7 1.3 2.7 2 0 0 2 2 2 2 twin BRCT domain BRCT PF00533.24 MSTRG.7655.1_1 - 2e-15 56.8 2.3 2.9e-05 24.3 0.3 4.2 3 1 0 3 3 3 3 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.3 MSTRG.7655.1_1 - 0.00016 21.4 0.0 0.017 14.8 0.0 2.9 3 0 0 3 3 3 1 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.3 MSTRG.7655.1_1 - 0.0083 16.3 2.9 0.11 12.6 1.2 2.6 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain BRO1 PF03097.16 MSTRG.9967.3_2 - 1.7e-113 379.2 3.7 1.7e-113 379.2 3.7 2.1 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.4 MSTRG.9967.3_2 - 2.2e-89 299.6 10.6 2.2e-89 299.6 10.6 2.2 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV RPT PF13446.4 MSTRG.9967.3_2 - 0.035 13.9 0.0 0.1 12.4 0.0 1.8 1 0 0 1 1 1 0 A repeated domain in UCH-protein DUF4116 PF13475.4 MSTRG.9967.3_2 - 0.056 13.0 0.0 0.17 11.5 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4116) HbrB PF08539.9 MSTRG.9967.3_2 - 0.19 11.6 2.6 3.8 7.3 0.0 3.1 3 0 0 3 3 3 0 HbrB-like Sec8_exocyst PF04048.12 MSTRG.9967.3_2 - 7.4 6.3 11.2 2.4 7.9 3.0 3.3 3 0 0 3 3 3 0 Sec8 exocyst complex component specific domain Calx-beta PF03160.12 MSTRG.27588.1_1 - 1.5e-17 63.5 4.4 1.5e-16 60.3 0.2 2.8 2 1 1 3 3 3 2 Calx-beta domain MDFI PF15316.4 MSTRG.18994.1_2 - 3.8 7.6 8.1 4.5 7.3 8.1 1.1 1 0 0 1 1 1 0 MyoD family inhibitor rve PF00665.24 MSTRG.28447.1_2 - 0.006 16.6 0.0 0.0077 16.3 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain DUF1534 PF07551.9 MSTRG.2089.1_2 - 0.039 13.6 0.9 0.074 12.7 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1534) CENP-F_leu_zip PF10473.7 MSTRG.2089.1_3 - 5.8e-06 26.2 20.5 0.00068 19.5 1.3 2.7 2 1 0 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IncA PF04156.12 MSTRG.2089.1_3 - 3.5e-05 23.6 17.3 3.9e-05 23.4 17.3 1.0 1 0 0 1 1 1 1 IncA protein Filament PF00038.19 MSTRG.2089.1_3 - 7.5e-05 22.3 11.4 0.00018 21.1 10.1 1.8 1 1 1 2 2 2 1 Intermediate filament protein ATG16 PF08614.9 MSTRG.2089.1_3 - 0.00031 20.8 15.4 0.00042 20.4 15.4 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Lebercilin PF15619.4 MSTRG.2089.1_3 - 0.00084 18.9 16.9 0.00092 18.8 16.9 1.1 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease DUF3287 PF11690.6 MSTRG.2089.1_3 - 0.0012 18.4 4.1 0.0083 15.7 0.1 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF3287) THOC7 PF05615.11 MSTRG.2089.1_3 - 0.0013 18.9 9.8 0.0025 18.0 9.8 1.4 1 1 0 1 1 1 1 Tho complex subunit 7 TPR_MLP1_2 PF07926.10 MSTRG.2089.1_3 - 0.002 18.1 9.4 0.002 18.1 9.4 1.7 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein FliJ PF02050.14 MSTRG.2089.1_3 - 0.0022 18.1 15.2 0.0084 16.2 8.5 2.0 1 1 1 2 2 2 2 Flagellar FliJ protein DUF4806 PF16064.3 MSTRG.2089.1_3 - 0.0046 17.1 3.8 0.02 15.1 0.4 2.5 1 1 2 3 3 3 1 Domain of unknown function (DUF4806) VGPC1_C PF16799.3 MSTRG.2089.1_3 - 0.0049 16.7 6.8 0.41 10.5 0.9 3.0 2 1 1 3 3 2 2 C-terminal membrane-localisation domain of ion-channel, VCN1 DUF948 PF06103.9 MSTRG.2089.1_3 - 0.0058 16.7 6.6 0.46 10.6 2.8 2.1 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF948) Bacillus_HBL PF05791.9 MSTRG.2089.1_3 - 0.013 15.1 6.9 0.018 14.6 6.9 1.2 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) RNA_pol_Rpb4 PF03874.14 MSTRG.2089.1_3 - 0.013 15.7 3.6 0.017 15.3 3.6 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb4 FUSC PF04632.10 MSTRG.2089.1_3 - 0.018 13.5 4.1 0.02 13.4 4.1 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family BLOC1_2 PF10046.7 MSTRG.2089.1_3 - 0.022 14.9 8.9 0.88 9.8 4.4 2.6 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HAP1_N PF04849.11 MSTRG.2089.1_3 - 0.031 13.3 13.5 0.07 12.2 13.5 1.6 1 1 0 1 1 1 0 HAP1 N-terminal conserved region Reo_sigmaC PF04582.10 MSTRG.2089.1_3 - 0.035 13.4 2.4 0.039 13.2 2.4 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Rho_Binding PF08912.9 MSTRG.2089.1_3 - 0.052 14.2 11.2 1.2 9.8 0.9 2.4 2 1 0 2 2 2 0 Rho Binding Laminin_I PF06008.12 MSTRG.2089.1_3 - 0.053 13.1 14.5 0.042 13.4 7.3 2.0 1 1 1 2 2 2 0 Laminin Domain I Phage_GPO PF05929.9 MSTRG.2089.1_3 - 0.059 12.9 9.3 0.067 12.7 9.3 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF1664 PF07889.10 MSTRG.2089.1_3 - 0.068 13.0 8.6 1.1 9.2 2.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF3734 PF12536.6 MSTRG.2089.1_3 - 0.079 13.2 3.3 0.35 11.1 0.6 2.3 1 1 1 2 2 2 0 Patatin phospholipase Mnd1 PF03962.13 MSTRG.2089.1_3 - 0.08 12.7 14.5 1.4 8.7 14.5 2.0 1 1 0 1 1 1 0 Mnd1 family DUF1216 PF06746.9 MSTRG.2089.1_3 - 0.08 12.8 7.6 0.025 14.5 4.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1216) DUF2508 PF10704.7 MSTRG.2089.1_3 - 0.084 12.9 4.8 0.12 12.4 0.8 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF2508) APG6 PF04111.10 MSTRG.2089.1_3 - 0.089 12.0 13.7 0.11 11.7 13.7 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Cortex-I_coil PF09304.8 MSTRG.2089.1_3 - 0.095 12.8 9.5 0.023 14.8 5.9 1.7 1 1 0 1 1 1 0 Cortexillin I, coiled coil Tropomyosin PF00261.18 MSTRG.2089.1_3 - 0.096 11.9 14.2 0.18 11.0 14.2 1.4 1 1 0 1 1 1 0 Tropomyosin EzrA PF06160.10 MSTRG.2089.1_3 - 0.1 10.6 10.2 0.86 7.6 10.2 1.9 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA TBPIP PF07106.11 MSTRG.2089.1_3 - 0.1 12.2 11.2 0.98 9.0 11.2 2.0 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Spc7 PF08317.9 MSTRG.2089.1_3 - 0.1 11.3 15.7 0.13 10.9 15.7 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF972 PF06156.11 MSTRG.2089.1_3 - 0.11 13.0 11.4 0.054 14.0 3.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Imm30 PF15565.4 MSTRG.2089.1_3 - 0.14 12.2 2.1 0.53 10.3 0.5 2.0 1 1 0 2 2 2 0 Immunity protein 30 Laminin_II PF06009.10 MSTRG.2089.1_3 - 0.14 12.0 8.1 0.22 11.4 5.2 2.0 1 1 1 2 2 2 0 Laminin Domain II Peptidase_M16 PF00675.18 MSTRG.2089.1_3 - 0.16 11.8 2.8 0.21 11.4 2.8 1.2 1 0 0 1 1 1 0 Insulinase (Peptidase family M16) 5_nucleotid PF05761.12 MSTRG.2089.1_3 - 0.18 10.5 6.2 0.21 10.3 6.2 1.2 1 0 0 1 1 1 0 5' nucleotidase family CENP-Q PF13094.4 MSTRG.2089.1_3 - 0.19 11.7 11.7 0.036 14.1 6.6 1.9 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit GAS PF13851.4 MSTRG.2089.1_3 - 0.21 10.8 14.3 0.59 9.3 14.3 1.7 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Lectin_N PF03954.12 MSTRG.2089.1_3 - 0.22 11.2 5.9 0.28 10.8 5.2 1.6 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain Kinetocho_Slk19 PF12709.5 MSTRG.2089.1_3 - 0.22 11.8 12.3 3.6 8.0 2.9 3.1 1 1 2 3 3 3 0 Central kinetochore-associated Macoilin PF09726.7 MSTRG.2089.1_3 - 0.23 9.8 14.8 0.25 9.7 14.8 1.0 1 0 0 1 1 1 0 Transmembrane protein NPV_P10 PF05531.10 MSTRG.2089.1_3 - 0.24 11.7 3.5 0.32 11.4 0.3 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein COG5 PF10392.7 MSTRG.2089.1_3 - 0.25 11.4 6.5 0.36 10.9 5.3 1.8 1 1 1 2 2 2 0 Golgi transport complex subunit 5 Nup88 PF10168.7 MSTRG.2089.1_3 - 0.26 8.9 12.2 0.25 8.9 12.2 1.0 1 0 0 1 1 1 0 Nuclear pore component PI3K_P85_iSH2 PF16454.3 MSTRG.2089.1_3 - 0.26 10.7 12.5 0.46 9.9 11.1 1.9 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Atg14 PF10186.7 MSTRG.2089.1_3 - 0.26 10.2 12.9 0.4 9.6 12.9 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_13 PF13166.4 MSTRG.2089.1_3 - 0.3 9.5 8.3 0.36 9.3 8.3 1.1 1 0 0 1 1 1 0 AAA domain Fez1 PF06818.13 MSTRG.2089.1_3 - 0.38 11.1 13.0 0.44 10.8 13.0 1.1 1 0 0 1 1 1 0 Fez1 Fib_alpha PF08702.8 MSTRG.2089.1_3 - 0.4 10.7 9.5 3.4 7.7 8.9 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family TMF_TATA_bd PF12325.6 MSTRG.2089.1_3 - 0.46 10.6 15.0 0.05 13.7 8.7 2.0 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding COG6 PF06419.9 MSTRG.2089.1_3 - 0.49 8.4 11.9 0.074 11.2 2.4 2.0 1 1 1 2 2 2 0 Conserved oligomeric complex COG6 ADIP PF11559.6 MSTRG.2089.1_3 - 0.58 10.1 16.4 13 5.7 15.1 2.0 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF2400 PF09674.8 MSTRG.2089.1_3 - 0.62 9.9 5.0 3.2 7.5 5.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2400) Sec34 PF04136.13 MSTRG.2089.1_3 - 0.7 9.6 7.8 0.53 10.0 3.8 1.9 1 1 1 2 2 2 0 Sec34-like family FlaC_arch PF05377.9 MSTRG.2089.1_3 - 0.72 10.2 9.3 0.65 10.3 0.5 3.0 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) FlgN PF05130.10 MSTRG.2089.1_3 - 0.75 10.2 14.3 5.6 7.3 14.3 2.0 1 1 0 1 1 1 0 FlgN protein TMPIT PF07851.11 MSTRG.2089.1_3 - 0.76 8.8 9.1 0.91 8.6 9.1 1.3 1 0 0 1 1 1 0 TMPIT-like protein Jnk-SapK_ap_N PF09744.7 MSTRG.2089.1_3 - 0.86 9.7 14.5 2.4 8.2 5.9 2.0 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 CREPT PF16566.3 MSTRG.2089.1_3 - 0.86 9.6 10.5 0.22 11.5 3.2 2.0 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour KELK PF15796.3 MSTRG.2089.1_3 - 0.9 9.9 15.3 5.4 7.4 1.9 2.9 2 1 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DMPK_coil PF08826.8 MSTRG.2089.1_3 - 1.1 9.3 13.1 1.4 8.9 4.9 3.0 1 1 2 3 3 3 0 DMPK coiled coil domain like Seryl_tRNA_N PF02403.20 MSTRG.2089.1_3 - 1.3 9.2 12.8 0.35 11.0 4.4 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF3450 PF11932.6 MSTRG.2089.1_3 - 1.4 8.1 16.0 0.72 9.0 6.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Mod_r PF07200.11 MSTRG.2089.1_3 - 1.5 8.8 14.0 3.3 7.7 7.1 2.1 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein PilO PF04350.11 MSTRG.2089.1_3 - 1.7 8.7 8.9 0.43 10.6 0.9 2.2 1 1 1 2 2 2 0 Pilus assembly protein, PilO Spc24 PF08286.9 MSTRG.2089.1_3 - 1.9 8.6 14.5 0.4 10.8 1.3 2.7 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Clusterin PF01093.15 MSTRG.2089.1_3 - 2 7.2 11.2 0.21 10.5 3.3 2.0 1 1 1 2 2 2 0 Clusterin FadA PF09403.8 MSTRG.2089.1_3 - 2.1 8.7 9.7 0.94 9.8 3.1 2.1 1 1 1 2 2 2 0 Adhesion protein FadA DUF2203 PF09969.7 MSTRG.2089.1_3 - 2.3 8.8 10.1 2.6 8.6 2.3 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) ACCA PF03255.12 MSTRG.2089.1_3 - 2.8 7.7 8.4 2.4 7.9 1.6 2.1 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Alanine_zipper PF11839.6 MSTRG.2089.1_3 - 3.3 7.9 7.3 6.4 7.0 0.3 2.7 1 1 2 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein bZIP_2 PF07716.13 MSTRG.2089.1_3 - 4.2 7.4 15.1 3 7.9 0.3 3.6 2 1 1 4 4 3 0 Basic region leucine zipper Nup54 PF13874.4 MSTRG.2089.1_3 - 5.6 6.9 13.1 4.4 7.3 11.0 1.8 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 DUF4446 PF14584.4 MSTRG.2089.1_3 - 5.8 6.8 8.3 8.2 6.3 2.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) XhlA PF10779.7 MSTRG.2089.1_3 - 6.4 6.9 9.5 6.4 6.9 0.1 3.0 2 1 1 3 3 3 0 Haemolysin XhlA DUF724 PF05266.12 MSTRG.2089.1_3 - 9.8 5.8 13.1 7 6.3 1.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) HemX PF04375.12 MSTRG.2089.1_3 - 9.8 5.2 15.2 1.8e+02 1.0 15.2 2.0 1 1 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF342 PF03961.11 MSTRG.2089.1_3 - 9.9 4.5 10.9 21 3.4 10.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF342) NCOA_u2 PF16665.3 MSTRG.13120.1_1 - 4.7e-32 110.6 18.3 4.7e-32 110.6 18.3 4.8 3 1 0 3 3 3 1 Unstructured region on nuclear receptor coactivator protein SRC-1 PF08832.8 MSTRG.13120.1_1 - 4.8e-31 107.5 2.7 4.8e-31 107.5 2.7 3.0 2 0 0 2 2 2 1 Steroid receptor coactivator PAS_11 PF14598.4 MSTRG.13120.1_1 - 3.1e-27 94.8 5.1 2e-24 85.8 0.0 3.2 3 0 0 3 3 3 2 PAS domain Nuc_rec_co-act PF08815.8 MSTRG.13120.1_1 - 1.1e-21 76.3 0.5 2.2e-21 75.4 0.5 1.5 1 0 0 1 1 1 1 Nuclear receptor coactivator DUF4927 PF16279.3 MSTRG.13120.1_1 - 2.9e-18 66.5 2.0 8e-18 65.1 0.6 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4927) PAS PF00989.23 MSTRG.13120.1_1 - 6.5e-08 32.4 0.0 2.1e-07 30.8 0.0 1.9 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.10 MSTRG.13120.1_1 - 6.9e-07 29.3 0.0 3.6e-05 23.8 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.5 MSTRG.13120.1_1 - 0.00014 21.9 0.0 0.00033 20.7 0.0 1.6 1 0 0 1 1 1 1 PAS domain HLH PF00010.24 MSTRG.13120.1_1 - 0.027 14.3 0.8 0.055 13.3 0.8 1.5 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain Oxysterol_BP PF01237.16 MSTRG.13427.2_1 - 8.6e-81 271.5 6.6 8.3e-79 264.9 6.6 2.1 1 1 0 1 1 1 1 Oxysterol-binding protein Med30 PF11315.6 MSTRG.9614.1_1 - 6.7e-50 169.0 1.2 9.4e-50 168.6 1.2 1.2 1 0 0 1 1 1 1 Mediator complex subunit 30 Sec7 PF01369.18 MSTRG.26412.1_1 - 0.00044 19.9 0.0 0.00086 19.0 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.5 MSTRG.26412.1_1 - 0.0018 18.1 0.3 0.01 15.7 0.3 2.2 1 1 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Spc97_Spc98 PF04130.11 MSTRG.26412.1_1 - 0.073 11.7 0.0 0.11 11.2 0.0 1.1 1 0 0 1 1 1 0 Spc97 / Spc98 family Transglut_C PF00927.20 MSTRG.27741.7_1 - 5.8e-11 42.3 0.0 9.5e-11 41.7 0.0 1.4 1 0 0 1 1 1 1 Transglutaminase family, C-terminal ig like domain Transglut_N PF00868.18 MSTRG.27741.7_3 - 2.4e-18 66.5 0.0 4.3e-18 65.7 0.0 1.4 1 0 0 1 1 1 1 Transglutaminase family Transglut_core PF01841.17 MSTRG.27741.7_3 - 3.3e-18 66.1 0.2 6.3e-18 65.1 0.2 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily Transglut_C PF00927.20 MSTRG.27741.7_3 - 0.00014 21.8 0.0 0.00041 20.3 0.0 1.7 1 0 0 1 1 1 1 Transglutaminase family, C-terminal ig like domain Recep_L_domain PF01030.22 MSTRG.20005.1_2 - 4.6e-28 97.4 0.1 8e-28 96.7 0.1 1.4 1 0 0 1 1 1 1 Receptor L domain Furin-like PF00757.18 MSTRG.20005.1_2 - 0.013 15.2 4.6 0.019 14.7 4.6 1.3 1 0 0 1 1 1 0 Furin-like cysteine rich region ICAT PF06384.9 MSTRG.18263.1_1 - 5.9e-25 87.2 0.0 1.1e-24 86.3 0.0 1.5 1 0 0 1 1 1 1 Beta-catenin-interacting protein ICAT Ank_2 PF12796.5 MSTRG.23404.2_1 - 0.00013 22.3 0.0 0.00023 21.6 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.23404.2_1 - 0.0031 17.9 0.0 0.0059 17.0 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.23404.2_1 - 0.089 13.3 0.0 23 5.8 0.0 2.6 2 0 0 2 2 2 0 Ankyrin repeat Ank_2 PF12796.5 MSTRG.23404.2_3 - 4.1e-62 206.6 20.0 5.5e-16 58.8 0.6 5.4 2 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.4 MSTRG.23404.2_3 - 1.2e-45 153.2 11.4 2e-12 47.3 0.1 7.8 4 4 4 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.23404.2_3 - 2.4e-41 134.8 13.7 2.4e-05 24.3 0.0 10.3 10 0 0 10 10 10 9 Ankyrin repeat Ank PF00023.28 MSTRG.23404.2_3 - 5.5e-34 115.0 19.7 4.1e-05 23.7 0.1 9.6 9 0 0 9 9 9 8 Ankyrin repeat Ank_5 PF13857.4 MSTRG.23404.2_3 - 3e-31 106.8 19.3 1.4e-10 41.1 0.3 7.9 3 3 5 9 9 9 5 Ankyrin repeats (many copies) SOCS_box PF07525.14 MSTRG.23404.2_3 - 2e-05 24.7 6.8 3.8e-05 23.8 6.8 1.4 1 0 0 1 1 1 1 SOCS box DUF4753 PF15945.3 MSTRG.5099.1_3 - 0.26 11.0 2.6 1.3 8.8 2.6 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4753) MOZ_SAS PF01853.16 MSTRG.4926.4_1 - 7e-81 270.0 0.2 1.1e-80 269.3 0.2 1.3 1 0 0 1 1 1 1 MOZ/SAS family PHD PF00628.27 MSTRG.4926.4_1 - 8.1e-19 67.1 26.7 5.6e-11 42.0 8.5 3.4 2 1 1 3 3 3 2 PHD-finger Linker_histone PF00538.17 MSTRG.4926.4_1 - 1.3e-07 31.8 0.0 0.00031 20.9 0.0 2.4 2 0 0 2 2 2 2 linker histone H1 and H5 family PHD_2 PF13831.4 MSTRG.4926.4_1 - 0.0037 16.6 2.0 0.0037 16.6 2.0 3.4 3 0 0 3 3 3 2 PHD-finger Acetyltransf_7 PF13508.5 MSTRG.4926.4_1 - 0.0065 16.7 0.0 0.018 15.3 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PHD_4 PF16866.3 MSTRG.4926.4_1 - 0.015 15.3 8.4 0.015 15.3 8.4 3.2 1 1 2 3 3 3 0 PHD-finger Prok-RING_1 PF14446.4 MSTRG.4926.4_1 - 3 7.7 15.0 6.8 6.6 0.5 2.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 RVT_1 PF00078.25 MSTRG.22254.1_2 - 1.8e-24 86.4 0.0 3.1e-24 85.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.4 MSTRG.22254.1_2 - 9.7e-07 29.1 0.0 1.8e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.4 MSTRG.22254.1_2 - 2.1e-05 25.0 0.0 3.5e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.8 MSTRG.22254.1_2 - 0.0063 16.2 0.1 0.012 15.2 0.1 1.4 1 0 0 1 1 1 1 Aspartyl protease BpuJI_N PF11564.6 MSTRG.22254.1_2 - 0.19 10.8 0.0 0.28 10.2 0.0 1.1 1 0 0 1 1 1 0 Restriction endonuclease BpuJI - N terminal zf-CCHC_2 PF13696.4 MSTRG.22254.1_3 - 0.00045 19.8 1.6 0.0031 17.1 0.3 2.7 2 0 0 2 2 2 1 Zinc knuckle FGF PF00167.16 MSTRG.7361.1_3 - 1.9e-39 134.5 0.0 3e-39 133.8 0.0 1.3 1 0 0 1 1 1 1 Fibroblast growth factor DUF4042 PF13251.4 MSTRG.7247.1_2 - 2.3e-70 235.9 0.1 2.3e-70 235.9 0.1 4.4 6 0 0 6 6 6 1 Domain of unknown function (DUF4042) HEAT_2 PF13646.4 MSTRG.7247.1_2 - 2.5e-13 50.1 9.6 0.00027 21.1 0.1 7.4 6 2 2 8 8 8 4 HEAT repeats HEAT PF02985.20 MSTRG.7247.1_2 - 3.1e-11 42.3 20.8 0.0051 16.8 0.0 10.2 12 0 0 12 12 12 2 HEAT repeat HEAT_EZ PF13513.4 MSTRG.7247.1_2 - 5.7e-10 39.3 19.0 0.053 13.9 0.1 8.4 8 0 0 8 8 8 5 HEAT-like repeat Cnd1 PF12717.5 MSTRG.7247.1_2 - 0.00019 21.3 9.0 1.1 9.1 0.6 5.2 6 0 0 6 6 6 3 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.7 MSTRG.7247.1_2 - 0.0012 18.9 8.9 0.3 11.1 0.0 4.7 5 0 0 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.21 MSTRG.7247.1_2 - 0.21 11.6 18.6 3.5 7.6 0.1 6.6 7 0 0 7 7 7 0 Armadillo/beta-catenin-like repeat HEAT_PBS PF03130.14 MSTRG.7247.1_2 - 0.98 10.2 3.6 12 6.8 0.0 4.7 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat SH2 PF00017.22 MSTRG.10972.1_3 - 2.2e-11 43.5 0.0 4.7e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.14 MSTRG.10972.1_3 - 6.3e-06 26.3 0.3 1.3e-05 25.3 0.3 1.6 1 0 0 1 1 1 1 SOCS box DDA1 PF10172.7 MSTRG.10377.1_3 - 6.2e-10 39.1 0.4 1.1e-09 38.3 0.4 1.4 1 0 0 1 1 1 1 Det1 complexing ubiquitin ligase BolA PF01722.16 MSTRG.25901.2_2 - 5.3e-20 71.4 0.1 9.4e-20 70.6 0.1 1.4 1 0 0 1 1 1 1 BolA-like protein zf-RING_2 PF13639.4 MSTRG.2145.1_2 - 4.9e-12 45.8 6.6 4.9e-12 45.8 6.6 2.2 2 0 0 2 2 1 1 Ring finger domain CUE PF02845.14 MSTRG.2145.1_2 - 4e-10 39.0 0.1 8e-10 38.1 0.1 1.5 1 0 0 1 1 1 1 CUE domain zf-C3HC4_2 PF13923.4 MSTRG.2145.1_2 - 1.2e-08 34.5 5.7 1.2e-08 34.5 5.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 MSTRG.2145.1_2 - 8.1e-08 31.9 4.4 8.1e-08 31.9 4.4 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 MSTRG.2145.1_2 - 1.4e-07 31.2 1.8 4.1e-07 29.8 1.8 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 MSTRG.2145.1_2 - 1.8e-07 30.7 2.4 1.8e-07 30.7 2.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 MSTRG.2145.1_2 - 5.3e-06 26.5 7.6 5.3e-06 26.5 7.6 2.7 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_11 PF17123.3 MSTRG.2145.1_2 - 2.2e-05 23.9 1.4 2.2e-05 23.9 1.4 2.5 2 0 0 2 2 2 1 RING-like zinc finger Prok-RING_4 PF14447.4 MSTRG.2145.1_2 - 4.5e-05 23.1 4.1 0.00011 21.8 4.1 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.3 MSTRG.2145.1_2 - 0.0002 20.8 4.6 0.00063 19.2 4.6 1.9 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.4 MSTRG.2145.1_2 - 0.00031 20.5 3.2 0.00031 20.5 3.2 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.5 MSTRG.2145.1_2 - 0.0021 17.9 2.6 0.0021 17.9 2.6 2.6 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.4 MSTRG.2145.1_2 - 0.025 14.6 4.1 0.065 13.3 4.1 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING RINGv PF12906.5 MSTRG.2145.1_2 - 3.3 7.8 9.5 2.8 8.0 7.0 2.3 2 0 0 2 2 2 0 RING-variant domain gerPA PF10676.7 MSTRG.17044.1_1 - 0.073 13.2 0.1 0.11 12.6 0.1 1.2 1 0 0 1 1 1 0 Spore germination protein gerPA/gerPF Macro PF01661.19 MSTRG.1520.2_1 - 3.5e-25 88.2 0.1 8.3e-25 87.0 0.0 1.7 2 0 0 2 2 2 1 Macro domain Histone_H2A_C PF16211.3 MSTRG.1520.2_1 - 1.2e-16 60.0 0.1 2.8e-16 58.8 0.1 1.7 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.22 MSTRG.1520.2_1 - 1.6e-13 51.1 0.0 1.6e-13 51.1 0.0 2.2 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 LcrG PF07216.10 MSTRG.1520.2_1 - 0.00045 19.9 0.2 0.069 12.9 0.1 2.5 2 0 0 2 2 2 1 LcrG protein CBFD_NFYB_HMF PF00808.21 MSTRG.1520.2_1 - 0.0018 18.4 0.0 0.0047 17.1 0.0 1.7 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Arm PF00514.21 MSTRG.5010.2_1 - 5.4e-05 23.0 5.8 0.00068 19.5 0.5 2.9 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.4 MSTRG.5010.2_1 - 0.047 14.0 4.2 0.36 11.1 3.6 2.3 1 1 0 1 1 1 0 HEAT repeats HEAT PF02985.20 MSTRG.5010.2_1 - 0.36 11.0 0.1 0.36 11.0 0.1 3.2 3 1 0 3 3 3 0 HEAT repeat HEAT_EZ PF13513.4 MSTRG.5010.2_1 - 0.54 10.7 7.0 0.3 11.5 1.0 3.1 1 1 2 3 3 3 0 HEAT-like repeat Evr1_Alr PF04777.11 MSTRG.16806.1_1 - 2e-20 73.0 0.0 1.9e-19 69.9 0.0 2.2 2 0 0 2 2 2 1 Erv1 / Alr family Thioredoxin PF00085.18 MSTRG.16806.1_1 - 7.4e-16 57.8 0.0 4.4e-15 55.4 0.1 2.1 2 0 0 2 2 2 1 Thioredoxin OST3_OST6 PF04756.11 MSTRG.16806.1_1 - 0.0003 20.1 0.6 0.001 18.3 0.0 2.0 3 0 0 3 3 3 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.4 MSTRG.16806.1_1 - 0.0055 16.9 0.0 0.84 9.9 0.1 2.7 2 1 0 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.4 MSTRG.16806.1_1 - 0.08 13.3 0.1 0.3 11.4 0.2 1.8 2 0 0 2 2 2 0 Thioredoxin-like domain Ank_4 PF13637.4 MSTRG.11420.1_1 - 1e-21 76.9 8.4 5.7e-13 49.0 0.1 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 MSTRG.11420.1_1 - 3.4e-18 65.9 2.1 3.8e-15 56.1 0.9 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 MSTRG.11420.1_1 - 1.4e-16 59.9 11.7 1.6e-08 34.5 0.2 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.4 MSTRG.11420.1_1 - 1.8e-15 56.7 12.3 4.9e-08 33.0 0.7 3.2 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.11420.1_1 - 9.4e-14 50.1 5.8 6.6e-06 26.0 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat dNK PF01712.17 MSTRG.17126.1_2 - 1.4e-70 237.2 0.1 1.8e-70 236.8 0.1 1.1 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_18 PF13238.4 MSTRG.17126.1_2 - 2.1e-05 24.9 0.1 0.00036 20.9 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.4 MSTRG.17126.1_2 - 3.8e-05 23.7 0.0 0.00029 20.9 0.0 2.1 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.15 MSTRG.17126.1_2 - 0.0084 15.7 0.0 0.066 12.7 0.0 2.1 2 0 0 2 2 2 1 Thymidylate kinase AAA_17 PF13207.4 MSTRG.17126.1_2 - 0.026 14.8 0.0 0.063 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.4 MSTRG.17126.1_2 - 0.031 14.4 0.0 0.065 13.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain PNTB PF02233.14 MSTRG.17427.2_1 - 1.2e-177 591.3 18.4 1.2e-177 591.3 18.4 2.2 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.19 MSTRG.17427.2_1 - 4.4e-70 235.2 0.1 1.1e-69 233.9 0.1 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.13 MSTRG.17427.2_1 - 2.2e-44 150.9 0.0 4.7e-44 149.9 0.0 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.5 MSTRG.17427.2_1 - 6.3e-32 109.8 3.1 6.3e-32 109.8 3.1 4.1 4 0 0 4 4 3 1 4TM region of pyridine nucleotide transhydrogenase, mitoch Pyr_redox_2 PF07992.12 MSTRG.17427.2_1 - 0.0022 17.1 0.2 0.0038 16.4 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ADH_zinc_N PF00107.24 MSTRG.17427.2_1 - 0.0075 16.0 0.2 0.038 13.8 0.2 2.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase GIDA PF01134.20 MSTRG.17427.2_1 - 0.011 14.7 1.0 0.017 14.1 1.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A 2-Hacid_dh_C PF02826.17 MSTRG.17427.2_1 - 0.016 14.4 0.3 1.3 8.3 0.1 2.4 1 1 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain HI0933_like PF03486.12 MSTRG.17427.2_1 - 0.081 11.5 1.4 0.13 10.8 1.4 1.3 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox PF00070.25 MSTRG.17427.2_1 - 0.14 12.6 0.2 0.32 11.5 0.2 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 MSTRG.17427.2_1 - 0.27 10.2 4.8 0.54 9.1 4.8 1.5 1 0 0 1 1 1 0 FAD binding domain NAD_binding_8 PF13450.4 MSTRG.17427.2_1 - 2.1 8.5 6.3 8.3 6.6 4.1 3.0 2 1 0 2 2 2 0 NAD(P)-binding Rossmann-like domain MitoNEET_N PF10660.7 MSTRG.11548.1_2 - 7.4e-23 80.2 0.3 7.4e-23 80.2 0.3 1.7 2 0 0 2 2 2 1 Iron-containing outer mitochondrial membrane protein N-terminus zf-CDGSH PF09360.8 MSTRG.11548.1_2 - 4.1e-08 33.2 0.3 4.1e-08 33.2 0.3 1.8 2 0 0 2 2 2 1 Iron-binding zinc finger CDGSH type ABC2_membrane PF01061.22 MSTRG.27333.1_2 - 1.3e-45 155.3 20.2 1.9e-45 154.7 20.2 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.25 MSTRG.27333.1_2 - 2.8e-08 34.2 0.0 4.2e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.17 MSTRG.27333.1_2 - 0.026 13.8 0.0 0.042 13.2 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_21 PF13304.4 MSTRG.27333.1_2 - 0.049 13.3 0.0 0.076 12.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF1440 PF07274.10 MSTRG.27333.1_2 - 0.13 12.4 3.8 0.3 11.3 0.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1440) ABC2_membrane_3 PF12698.5 MSTRG.27333.1_2 - 0.28 10.1 23.3 0.059 12.3 17.8 2.0 1 1 1 2 2 2 0 ABC-2 family transporter protein DUF3679 PF12438.6 MSTRG.7588.1_1 - 0.043 13.4 0.1 0.074 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3679) PP1_inhibitor PF05361.10 MSTRG.7588.1_2 - 7.4e-29 100.4 1.9 1e-28 99.9 1.9 1.1 1 0 0 1 1 1 1 PKC-activated protein phosphatase-1 inhibitor Siah-Interact_N PF09032.9 MSTRG.7588.1_2 - 0.0023 18.1 0.5 0.0047 17.1 0.5 1.5 1 0 0 1 1 1 1 Siah interacting protein, N terminal AKAP7_NLS PF10469.7 MSTRG.7588.1_2 - 0.09 12.5 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 AKAP7 2'5' RNA ligase-like domain V-set PF07686.15 MSTRG.23341.1_1 - 0.00029 20.8 0.0 0.00071 19.6 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 MSTRG.23341.1_1 - 0.033 14.7 0.0 0.064 13.7 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain ig PF00047.23 MSTRG.23341.1_1 - 0.045 13.8 0.4 0.085 12.9 0.1 1.6 2 0 0 2 2 2 0 Immunoglobulin domain ITAM PF02189.13 MSTRG.23341.1_1 - 0.11 12.8 0.5 0.6 10.6 0.1 2.2 2 0 0 2 2 2 0 Immunoreceptor tyrosine-based activation motif Pkinase_Tyr PF07714.15 MSTRG.10508.1_3 - 5.5e-95 317.4 0.0 8.1e-95 316.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.17 MSTRG.10508.1_3 - 3.9e-71 238.6 0.1 7.2e-71 237.8 0.1 1.5 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.23 MSTRG.10508.1_3 - 3.7e-46 157.5 0.0 5e-46 157.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.19 MSTRG.10508.1_3 - 5.8e-33 113.0 2.0 1.1e-15 57.6 0.0 3.5 4 0 0 4 4 4 2 Fibronectin type III domain EphA2_TM PF14575.4 MSTRG.10508.1_3 - 2.1e-21 76.4 0.3 2.1e-21 76.4 0.3 2.5 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain Pur_ac_phosph_N PF16656.3 MSTRG.10508.1_3 - 1.8e-06 28.3 0.1 0.00058 20.2 0.0 2.6 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain SAM_1 PF00536.28 MSTRG.10508.1_3 - 5.4e-05 23.4 0.1 0.00012 22.3 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ephrin_rec_like PF07699.11 MSTRG.10508.1_3 - 0.0002 21.0 7.7 0.00056 19.5 7.7 1.8 1 0 0 1 1 1 1 Putative ephrin-receptor like SAM_2 PF07647.15 MSTRG.10508.1_3 - 0.0031 17.5 0.1 0.0081 16.1 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) fn3_2 PF16893.3 MSTRG.10508.1_3 - 0.038 14.0 0.0 2.8 8.0 0.0 2.6 2 0 0 2 2 2 0 Fibronectin type III domain Cadherin_C_2 PF16492.3 MSTRG.10508.1_3 - 0.04 14.6 0.1 0.04 14.6 0.1 2.6 2 1 0 2 2 1 0 Cadherin cytoplasmic C-terminal Serpin PF00079.18 MSTRG.4292.1_2 - 6.7e-109 364.5 0.0 8.2e-109 364.2 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Torus PF16131.3 MSTRG.12334.2_1 - 0.0013 19.2 0.1 0.006 17.1 0.0 2.2 2 0 0 2 2 2 1 Torus domain zf-CCCH PF00642.22 MSTRG.12334.2_1 - 0.011 15.5 0.9 0.028 14.2 0.9 1.7 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.4 MSTRG.12334.2_1 - 0.033 14.5 3.8 0.1 13.0 3.8 1.9 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Peptidase_M48_N PF16491.3 MSTRG.1813.1_2 - 3.9e-66 222.3 2.5 8.7e-66 221.2 2.5 1.6 1 0 0 1 1 1 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.16 MSTRG.1813.1_2 - 4.7e-64 215.7 0.0 6.2e-64 215.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M48 Amidohydro_1 PF01979.18 MSTRG.19892.1_3 - 5.8e-06 25.7 0.0 8.1e-06 25.2 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.9 MSTRG.19892.1_3 - 0.00019 20.9 0.2 0.00029 20.3 0.2 1.2 1 0 0 1 1 1 1 Amidohydrolase family PRP4 PF08799.9 MSTRG.22256.1_3 - 0.055 12.9 0.3 5.7 6.4 0.0 2.6 2 0 0 2 2 2 0 pre-mRNA processing factor 4 (PRP4) like Crystall PF00030.17 MSTRG.15772.1_1 - 8.7e-55 182.8 6.0 2e-28 98.3 0.4 2.2 2 0 0 2 2 2 2 Beta/Gamma crystallin NeuB PF03102.12 MSTRG.11464.1_1 - 1.3e-79 266.9 0.1 1.7e-79 266.5 0.1 1.1 1 0 0 1 1 1 1 NeuB family SAF PF08666.10 MSTRG.11464.1_1 - 0.00043 20.7 0.3 0.00096 19.6 0.3 1.6 1 0 0 1 1 1 1 SAF domain DUF2458 PF10454.7 MSTRG.11464.1_1 - 0.097 12.2 0.1 0.15 11.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) Zona_pellucida PF00100.21 MSTRG.17736.1_2 - 3e-29 102.4 0.0 4.7e-29 101.8 0.0 1.3 1 0 0 1 1 1 1 Zona pellucida-like domain CAP_N PF01213.17 MSTRG.8753.1_3 - 0.28 10.5 6.7 0.4 10.0 6.7 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.3 MSTRG.8753.1_3 - 1.1 9.1 9.5 2.2 8.2 9.5 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 zf-H2C2_2 PF13465.4 MSTRG.196.1_2 - 6.3e-63 206.4 71.0 1.1e-08 35.0 0.5 10.5 10 0 0 10 10 10 9 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.196.1_2 - 2e-38 128.6 93.8 2.5e-05 24.3 1.4 10.6 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.196.1_2 - 1.6e-29 99.9 85.2 0.00064 20.2 2.3 10.6 10 0 0 10 10 10 10 C2H2-type zinc finger DUF3268 PF11672.6 MSTRG.196.1_2 - 0.00027 21.1 15.6 1.1 9.5 0.1 5.1 4 1 1 5 5 5 3 zinc-finger-containing domain zf-LYAR PF08790.9 MSTRG.196.1_2 - 0.0011 18.7 52.4 0.22 11.3 0.2 10.3 10 0 0 10 10 10 3 LYAR-type C2HC zinc finger CNRIP1 PF15043.4 MSTRG.196.1_2 - 0.0025 17.2 2.9 0.14 11.6 0.0 4.2 2 2 2 5 5 5 1 CB1 cannabinoid receptor-interacting protein 1 zf-C2H2_6 PF13912.4 MSTRG.196.1_2 - 0.0026 17.5 2.1 0.0026 17.5 2.1 9.8 10 1 0 10 10 10 3 C2H2-type zinc finger zf-met PF12874.5 MSTRG.196.1_2 - 0.0027 17.9 3.0 0.0027 17.9 3.0 9.7 10 0 0 10 10 10 1 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.8 MSTRG.196.1_2 - 0.0043 17.0 38.2 0.26 11.3 2.2 7.0 4 3 3 7 7 7 4 Zinc ribbon domain zf-Di19 PF05605.10 MSTRG.196.1_2 - 0.0085 16.2 3.4 0.0085 16.2 3.4 6.7 3 2 2 7 7 6 3 Drought induced 19 protein (Di19), zinc-binding Elf1 PF05129.11 MSTRG.196.1_2 - 0.33 10.9 39.5 0.044 13.7 3.0 5.9 1 1 5 6 6 6 0 Transcription elongation factor Elf1 like LIM PF00412.20 MSTRG.196.1_2 - 0.36 10.9 47.4 0.27 11.4 2.0 8.3 1 1 4 7 7 7 0 LIM domain HypA PF01155.17 MSTRG.196.1_2 - 0.7 9.8 33.5 0.5 10.3 0.6 6.2 1 1 6 7 7 7 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA BolA PF01722.16 MSTRG.196.1_2 - 0.99 9.6 15.4 36 4.6 1.9 5.4 1 1 2 3 3 3 0 BolA-like protein zinc_ribbon_15 PF17032.3 MSTRG.196.1_2 - 1.1 10.0 39.0 0.28 11.8 0.8 5.8 2 1 2 6 6 5 0 zinc-ribbon family DUF2180 PF09947.7 MSTRG.196.1_2 - 1.7 8.6 15.9 3.1 7.7 0.1 5.6 1 1 6 7 7 7 0 Uncharacterized protein conserved in archaea (DUF2180) Chordopox_RPO7 PF05864.10 MSTRG.196.1_2 - 3 8.0 8.3 68 3.7 0.0 5.2 7 0 0 7 7 5 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) zf-C2H2_11 PF16622.3 MSTRG.196.1_2 - 4.8 6.9 59.7 0.34 10.6 1.0 9.8 10 0 0 10 10 10 0 zinc-finger C2H2-type DUF829 PF05705.12 MSTRG.7015.2_3 - 1.3e-64 218.3 0.0 1.7e-64 217.9 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) Hydrolase_4 PF12146.6 MSTRG.7015.2_3 - 0.094 11.8 0.0 6.3 5.9 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Filamin PF00630.17 MSTRG.20474.3_2 - 0 1191.2 42.8 3.7e-18 66.1 0.0 23.2 23 0 0 23 23 23 23 Filamin/ABP280 repeat CH PF00307.29 MSTRG.20474.3_2 - 5.9e-39 132.5 1.1 8.1e-21 74.1 0.9 2.6 2 0 0 2 2 2 2 Calponin homology (CH) domain Y_Y_Y PF07495.11 MSTRG.20474.3_2 - 9.8e-19 66.9 19.4 0.16 11.8 0.1 13.9 14 0 0 14 14 14 5 Y_Y_Y domain Big_3_5 PF16640.3 MSTRG.20474.3_2 - 6.2e-12 45.4 41.8 0.0085 16.1 0.1 14.6 17 0 0 17 17 17 4 Bacterial Ig-like domain (group 3) DUF5060 PF16586.3 MSTRG.20474.3_2 - 8.4e-12 45.2 2.4 6.1 7.1 0.0 12.6 15 0 0 15 15 14 1 Domain of unknown function (DUF5060) YtkA PF13115.4 MSTRG.20474.3_2 - 1.2e-10 41.7 12.0 0.86 10.1 0.0 12.8 15 0 0 15 15 14 1 YtkA-like Invasin_D3 PF09134.8 MSTRG.20474.3_2 - 5.9e-07 29.0 3.7 10 5.8 0.0 8.8 10 0 0 10 10 10 1 Invasin, domain 3 PapC_N PF13954.4 MSTRG.20474.3_2 - 1.5e-05 24.9 0.0 1.6 8.5 0.0 6.6 7 1 0 7 7 7 1 PapC N-terminal domain EMP24_GP25L PF01105.22 MSTRG.20474.3_2 - 0.00032 20.6 0.1 1.7 8.4 0.0 5.7 7 0 0 7 7 7 1 emp24/gp25L/p24 family/GOLD CarboxypepD_reg PF13620.4 MSTRG.20474.3_2 - 0.00047 20.2 29.5 0.015 15.4 0.1 11.9 14 1 1 15 15 12 1 Carboxypeptidase regulatory-like domain Wzt_C PF14524.4 MSTRG.20474.3_2 - 0.01 15.7 0.2 5.8 6.8 0.0 5.0 5 0 0 5 5 5 0 Wzt C-terminal domain CH_2 PF06294.9 MSTRG.20474.3_2 - 0.033 14.2 0.4 1 9.4 0.1 2.3 2 0 0 2 2 2 0 CH-like domain in sperm protein DUF4369 PF14289.4 MSTRG.20474.3_2 - 0.27 11.8 1.5 12 6.4 0.1 4.5 6 0 0 6 6 5 0 Domain of unknown function (DUF4369) NDK PF00334.17 MSTRG.6434.1_2 - 1.6e-52 177.0 0.0 2.1e-52 176.6 0.0 1.2 1 0 0 1 1 1 1 Nucleoside diphosphate kinase SET PF00856.26 MSTRG.23170.1_2 - 0.0011 19.2 0.0 0.0012 19.1 0.0 1.1 1 0 0 1 1 1 1 SET domain SET PF00856.26 MSTRG.23170.1_3 - 0.00078 19.7 0.1 0.00091 19.5 0.1 1.3 1 1 0 1 1 1 1 SET domain LIM PF00412.20 MSTRG.6941.1_1 - 2.6e-34 117.1 34.3 2.3e-12 46.8 6.8 3.5 3 0 0 3 3 3 3 LIM domain PH PF00169.27 MSTRG.15805.1_2 - 4.5e-06 27.0 0.3 7.8e-06 26.2 0.3 1.4 1 0 0 1 1 1 1 PH domain SH2 PF00017.22 MSTRG.15805.1_2 - 3.8e-05 23.5 0.0 8.6e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 SH2 domain SH2_2 PF14633.4 MSTRG.15805.1_2 - 0.00071 18.9 0.0 0.0012 18.1 0.0 1.3 1 0 0 1 1 1 1 SH2 domain RA PF00788.21 MSTRG.12360.1_1 - 0.0036 17.8 0.0 0.021 15.3 0.0 2.3 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain TraC_F_IV PF11130.6 MSTRG.12360.1_1 - 0.032 13.7 0.2 0.073 12.5 0.2 1.5 1 0 0 1 1 1 0 F pilus assembly Type-IV secretion system for plasmid transfer CENP-B_dimeris PF09026.8 MSTRG.12360.1_1 - 0.83 9.9 11.8 2.3 8.5 11.8 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain BLOC1_2 PF10046.7 MSTRG.12360.1_1 - 6.6 7.0 12.0 0.13 12.4 3.4 2.4 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Katanin_con80 PF13925.4 MSTRG.21581.1_2 - 4.7e-51 172.8 0.3 6e-51 172.5 0.3 1.1 1 0 0 1 1 1 1 con80 domain of Katanin MBOAT PF03062.17 MSTRG.6967.1_1 - 2.9e-61 207.6 10.5 5.5e-61 206.7 10.5 1.5 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Xin PF08043.10 MSTRG.6967.1_1 - 3.8 7.2 9.6 0.42 10.2 0.6 3.2 3 0 0 3 3 3 0 Xin repeat SOSSC PF15925.3 MSTRG.11241.1_2 - 3.7e-17 63.3 0.2 1.7e-16 61.2 0.2 1.9 1 1 0 1 1 1 1 SOSS complex subunit C tRNA-synt_1b PF00579.23 MSTRG.11241.1_3 - 3e-71 240.0 0.0 4.1e-71 239.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) tRNA_bind PF01588.18 MSTRG.11241.1_3 - 2.4e-29 101.2 0.0 4.2e-29 100.4 0.0 1.4 1 0 0 1 1 1 1 Putative tRNA binding domain ERK-JNK_inhib PF15002.4 MSTRG.7969.1_1 - 2.1e-68 229.7 0.1 2.1e-68 229.7 0.1 1.4 2 0 0 2 2 2 1 ERK and JNK pathways, inhibitor Ank_2 PF12796.5 MSTRG.3022.1_3 - 7.9e-134 436.4 27.4 1.7e-16 60.5 0.1 11.0 1 1 10 11 11 11 11 Ankyrin repeats (3 copies) Ank PF00023.28 MSTRG.3022.1_3 - 4.6e-129 415.6 52.7 4.1e-08 33.2 0.0 19.7 19 0 0 19 19 19 19 Ankyrin repeat Ank_4 PF13637.4 MSTRG.3022.1_3 - 1.1e-111 363.7 23.9 1.8e-13 50.6 0.1 13.4 5 3 5 13 13 13 12 Ankyrin repeats (many copies) Ank_3 PF13606.4 MSTRG.3022.1_3 - 3.1e-110 346.5 28.6 1.5e-07 31.0 0.0 19.5 19 0 0 19 19 19 19 Ankyrin repeat Ank_5 PF13857.4 MSTRG.3022.1_3 - 6.7e-102 331.6 37.2 2.2e-10 40.4 0.1 17.1 2 2 17 19 19 19 17 Ankyrin repeats (many copies) ZU5 PF00791.18 MSTRG.3022.1_3 - 1.9e-28 98.5 0.0 4.2e-27 94.2 0.0 2.6 2 0 0 2 2 2 1 ZU5 domain Staufen_C PF16482.3 MSTRG.3022.1_3 - 0.11 12.5 0.3 55 3.8 0.1 3.8 3 0 0 3 3 3 0 Staufen C-terminal domain Crystall PF00030.17 MSTRG.15615.1_2 - 1.1e-57 192.0 0.7 2.8e-30 104.2 0.1 2.3 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 MSTRG.15615.1_2 - 1.6e-07 31.0 0.0 0.0052 16.6 0.0 3.2 4 1 0 4 4 4 2 Peptidase inhibitor family I36 Crystall_3 PF08964.8 MSTRG.15615.1_2 - 0.063 13.3 0.2 0.26 11.3 0.1 2.1 2 1 0 2 2 2 0 Beta/Gamma crystallin Toxin_28 PF08115.9 MSTRG.15615.1_3 - 9.2 6.1 8.8 1.2 8.9 3.0 2.5 2 0 0 2 2 2 0 SFI toxin family RA PF00788.21 MSTRG.22049.2_3 - 4.1e-08 33.6 0.3 9.5e-08 32.4 0.0 1.8 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain Exonuc_VII_L PF02601.13 MSTRG.22049.2_3 - 0.26 10.7 7.9 0.38 10.1 7.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Mu-like_Pro PF10123.7 MSTRG.22049.2_3 - 0.4 10.0 5.3 0.63 9.3 5.3 1.2 1 0 0 1 1 1 0 Mu-like prophage I protein RRF_GI PF12614.6 MSTRG.22049.2_3 - 0.97 9.5 7.9 0.54 10.3 5.4 1.8 1 1 1 2 2 2 0 Ribosome recycling factor DUF1664 PF07889.10 MSTRG.22049.2_3 - 2.5 8.0 9.7 4.6 7.1 1.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DivIVA PF05103.11 MSTRG.22049.2_3 - 7.4 6.5 13.9 13 5.7 12.3 2.2 1 1 0 1 1 1 0 DivIVA protein DUF2203 PF09969.7 MSTRG.22049.2_3 - 8 7.1 14.9 2.5 8.7 3.3 2.4 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Ion_trans PF00520.29 MSTRG.23535.1_2 - 2.3e-17 62.9 4.7 2.7e-17 62.7 4.7 1.0 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.10 MSTRG.23535.1_2 - 0.01 14.4 3.3 0.011 14.3 3.3 1.0 1 0 0 1 1 1 0 Polycystin cation channel TEP1_N PF05386.9 MSTRG.23535.1_3 - 0.085 12.3 1.7 0.085 12.3 1.7 2.0 2 0 0 2 2 2 0 TEP1 N-terminal domain TMEM154 PF15102.4 MSTRG.14988.1_3 - 0.001 18.9 0.1 0.0013 18.5 0.1 1.2 1 0 0 1 1 1 1 TMEM154 protein family DALR_1 PF05746.13 MSTRG.3139.1_3 - 3.4e-14 52.9 0.0 5.4e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 DALR anticodon binding domain Sortilin-Vps10 PF15902.3 MSTRG.26740.1_1 - 1.4e-108 363.5 0.0 1.7e-108 363.2 0.0 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.3 MSTRG.26740.1_1 - 2.7e-37 128.6 0.7 5.1e-37 127.7 0.7 1.5 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR_6 PF15899.3 MSTRG.26740.1_1 - 7e-13 47.2 13.4 0.0021 17.8 0.2 5.8 6 0 0 6 6 6 4 BNR-Asp box repeat BNR PF02012.18 MSTRG.26740.1_1 - 4.4e-07 28.8 25.4 0.79 9.8 0.3 8.8 8 0 0 8 8 8 4 BNR/Asp-box repeat Mo-co_dimer PF03404.14 MSTRG.26740.1_1 - 0.098 12.5 0.0 1.5 8.7 0.0 2.7 4 0 0 4 4 4 0 Mo-co oxidoreductase dimerisation domain AA_permease PF00324.19 MSTRG.8121.2_3 - 2.4e-63 214.2 33.4 1.7e-41 142.2 5.5 2.1 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.13 MSTRG.8121.2_3 - 1e-50 172.9 1.4 2.2e-18 66.4 0.0 3.2 2 1 1 3 3 3 3 Solute carrier family 12 AA_permease_2 PF13520.4 MSTRG.8121.2_3 - 5.5e-17 61.6 14.4 5.5e-17 61.6 14.4 2.2 2 0 0 2 2 2 2 Amino acid permease G-gamma PF00631.20 MSTRG.13571.1_3 - 4.3e-12 45.7 0.0 7.6e-12 44.9 0.0 1.4 1 0 0 1 1 1 1 GGL domain Pkinase_Tyr PF07714.15 MSTRG.5158.2_1 - 3.4e-63 213.2 0.0 4.6e-63 212.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.5158.2_1 - 8e-58 195.7 0.0 1.1e-57 195.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain RBD PF02196.13 MSTRG.5158.2_1 - 2.6e-26 91.4 0.0 7.5e-26 89.9 0.0 1.9 1 0 0 1 1 1 1 Raf-like Ras-binding domain C1_1 PF00130.20 MSTRG.5158.2_1 - 3.4e-12 45.9 7.1 8.2e-12 44.7 7.1 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.4 MSTRG.5158.2_1 - 2.6e-08 33.4 0.0 3.8e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like zf-RING-like PF08746.9 MSTRG.5158.2_1 - 6.8e-05 23.0 2.7 0.00024 21.2 2.7 2.0 1 0 0 1 1 1 1 RING-like domain C1_2 PF03107.14 MSTRG.5158.2_1 - 0.0034 17.5 3.6 0.0085 16.3 3.6 1.7 1 0 0 1 1 1 1 C1 domain APH PF01636.21 MSTRG.5158.2_1 - 0.054 13.3 0.0 0.17 11.6 0.0 1.8 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.12 MSTRG.5158.2_1 - 0.15 11.3 0.1 0.23 10.6 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ST7 PF04184.10 MSTRG.22573.1_3 - 6e-301 998.5 0.4 6.9e-301 998.3 0.4 1.0 1 0 0 1 1 1 1 ST7 protein TPR_6 PF13174.4 MSTRG.22573.1_3 - 0.0016 18.8 0.0 0.0073 16.7 0.0 2.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.15 MSTRG.22573.1_3 - 0.09 12.8 0.1 14 5.9 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Clathrin PF00637.18 MSTRG.22573.1_3 - 0.09 12.5 0.1 0.18 11.5 0.1 1.4 1 0 0 1 1 1 0 Region in Clathrin and VPS TPR_19 PF14559.4 MSTRG.22573.1_3 - 0.61 10.5 3.1 1.7 9.1 0.0 2.9 3 1 0 3 3 3 0 Tetratricopeptide repeat DLIC PF05783.9 MSTRG.4599.2_2 - 0.3 9.7 1.0 0.44 9.2 1.0 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) N-SET PF11764.6 MSTRG.8679.3_2 - 2.5e-06 27.5 0.4 2.5e-06 27.5 0.4 3.0 2 1 1 3 3 3 1 COMPASS (Complex proteins associated with Set1p) component N SET PF00856.26 MSTRG.8679.3_3 - 2.6e-18 66.9 1.4 6.9e-18 65.5 1.4 1.7 1 1 0 1 1 1 1 SET domain N-SET PF11764.6 MSTRG.8679.3_3 - 1.9e-15 57.2 0.4 4.8e-15 55.9 0.4 1.6 1 1 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component N Arrestin_N PF00339.27 MSTRG.5712.1_3 - 3.4e-22 79.0 1.0 2.9e-19 69.4 0.2 2.3 2 1 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.20 MSTRG.5712.1_3 - 9.9e-08 32.3 4.3 2.3e-06 27.9 0.9 2.5 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Ribosomal_S21 PF01165.18 MSTRG.23292.1_1 - 0.37 10.4 3.1 2.2 8.0 1.2 2.1 2 0 0 2 2 2 0 Ribosomal protein S21 zf-H2C2_2 PF13465.4 MSTRG.16119.1_3 - 1.1e-48 161.4 57.6 3.3e-10 39.8 1.2 8.6 9 0 0 9 9 8 7 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.16119.1_3 - 2.1e-29 100.2 60.7 1.3e-05 25.2 0.7 7.9 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.16119.1_3 - 1.5e-19 68.8 63.6 6.1e-05 23.4 1.0 8.5 9 0 0 9 9 8 7 C2H2-type zinc finger zf-met PF12874.5 MSTRG.16119.1_3 - 5.9e-08 32.7 46.1 0.017 15.3 3.1 7.5 7 0 0 7 7 7 4 Zinc-finger of C2H2 type zf-Di19 PF05605.10 MSTRG.16119.1_3 - 6.3e-05 23.1 23.9 9.9e-05 22.4 1.7 4.3 2 2 3 5 5 5 3 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.4 MSTRG.16119.1_3 - 0.00025 20.6 43.7 0.0051 16.4 1.2 8.2 8 1 0 8 8 8 3 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.6 MSTRG.16119.1_3 - 0.0024 18.0 27.5 0.97 9.7 0.6 7.1 7 0 0 7 7 7 2 Zinc-finger double-stranded RNA-binding Elf1 PF05129.11 MSTRG.16119.1_3 - 0.0031 17.4 31.6 0.024 14.6 1.6 4.4 1 1 3 4 4 4 2 Transcription elongation factor Elf1 like zf-C2H2_11 PF16622.3 MSTRG.16119.1_3 - 0.0041 16.7 3.1 0.033 13.8 0.2 6.6 7 0 0 7 7 7 3 zinc-finger C2H2-type GATA PF00320.25 MSTRG.16119.1_3 - 0.048 13.2 0.6 0.048 13.2 0.6 3.9 4 1 0 4 4 4 0 GATA zinc finger zf-C2H2_6 PF13912.4 MSTRG.16119.1_3 - 0.12 12.2 41.5 0.057 13.3 1.0 8.2 7 1 0 7 7 7 0 C2H2-type zinc finger zf-C2H2_2 PF12756.5 MSTRG.16119.1_3 - 0.12 12.5 32.0 14 6.0 0.1 6.6 1 1 5 6 6 6 0 C2H2 type zinc-finger (2 copies) ADK_lid PF05191.12 MSTRG.16119.1_3 - 0.2 11.6 0.2 0.2 11.6 0.2 3.8 2 2 1 3 3 3 0 Adenylate kinase, active site lid zf-Sec23_Sec24 PF04810.13 MSTRG.16119.1_3 - 0.23 11.4 26.7 1.1 9.2 0.1 6.5 7 0 0 7 7 7 0 Sec23/Sec24 zinc finger BolA PF01722.16 MSTRG.16119.1_3 - 0.27 11.4 10.7 3.5 7.8 0.2 4.2 2 1 2 4 4 4 0 BolA-like protein zinc_ribbon_15 PF17032.3 MSTRG.16119.1_3 - 0.35 11.5 23.4 1.4 9.6 2.1 4.3 1 1 1 4 4 4 0 zinc-ribbon family zf-BED PF02892.13 MSTRG.16119.1_3 - 2.4 8.2 39.0 3.6 7.6 1.0 6.6 1 1 5 6 6 6 0 BED zinc finger zf-LYAR PF08790.9 MSTRG.16119.1_3 - 3.6 7.4 34.8 0.44 10.3 0.1 7.0 7 0 0 7 7 7 0 LYAR-type C2HC zinc finger C1_4 PF07975.10 MSTRG.16119.1_3 - 3.7 7.8 29.7 1.1 9.4 0.2 4.9 3 2 1 4 4 4 0 TFIIH C1-like domain DUF3268 PF11672.6 MSTRG.16119.1_3 - 3.7 7.8 11.1 5.8 7.2 0.1 3.2 3 1 0 3 3 3 0 zinc-finger-containing domain Zn-ribbon_8 PF09723.8 MSTRG.16119.1_3 - 6.5 6.8 28.1 0.099 12.6 1.5 5.1 2 2 3 5 5 5 0 Zinc ribbon domain HypA PF01155.17 MSTRG.16119.1_3 - 7 6.6 24.3 3.9 7.4 1.6 4.4 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ribbon_3 PF13248.4 MSTRG.16119.1_3 - 9.5 5.7 15.2 12 5.3 0.2 5.1 5 0 0 5 5 5 0 zinc-ribbon domain 7tm_1 PF00001.19 MSTRG.23115.1_1 - 4.8e-39 134.1 9.8 4.8e-39 134.1 9.8 2.1 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) Rhodopsin_N PF10413.7 MSTRG.23115.1_1 - 4.7e-25 87.0 3.4 1e-24 85.9 3.4 1.6 1 0 0 1 1 1 1 Amino terminal of the G-protein receptor rhodopsin 7tm_4 PF13853.4 MSTRG.23115.1_1 - 0.00046 19.9 7.8 0.06 12.9 0.4 2.2 2 0 0 2 2 2 2 Olfactory receptor DUF4079 PF13301.4 MSTRG.23115.1_1 - 3.2 7.8 7.9 5.8 6.9 3.8 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) Peptidase_M24_C PF16188.3 MSTRG.15919.1_3 - 4.5e-19 68.1 0.3 5.8e-19 67.8 0.3 1.1 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 DUF3915 PF13054.4 MSTRG.16596.2_1 - 0.66 9.8 3.1 1.3 8.8 3.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Tet_JBP PF12851.5 MSTRG.16596.2_2 - 1.8e-105 352.8 0.1 2.5e-104 349.1 0.1 2.5 1 1 0 1 1 1 1 Oxygenase domain of the 2OGFeDO superfamily DUF3915 PF13054.4 MSTRG.16596.2_3 - 2.8 7.8 6.6 6.9 6.5 6.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Proteasome PF00227.24 MSTRG.21418.1_3 - 2.1e-61 206.6 0.0 2.9e-61 206.2 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.7 MSTRG.21418.1_3 - 8.5e-10 38.0 0.1 1.7e-09 37.0 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature PBP_dimer PF03717.13 MSTRG.21418.1_3 - 0.11 12.7 0.0 4.6 7.4 0.0 2.1 2 0 0 2 2 2 0 Penicillin-binding Protein dimerisation domain zf-CCCH PF00642.22 MSTRG.8040.2_2 - 1.7e-12 46.8 18.0 0.00039 20.1 0.6 4.8 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.3 MSTRG.8040.2_2 - 0.0022 18.1 15.3 0.056 13.6 1.3 2.8 2 1 0 2 2 2 2 Zinc-finger containing family zf-CCCH_2 PF14608.4 MSTRG.8040.2_2 - 2.8 8.4 33.6 1 9.8 1.0 5.2 5 0 0 5 5 5 0 RNA-binding, Nab2-type zinc finger HCO3_cotransp PF00955.19 MSTRG.2263.1_1 - 7e-131 437.5 0.8 1e-130 436.9 0.8 1.3 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 MSTRG.2263.1_1 - 7.4e-107 357.0 1.2 7.4e-107 357.0 1.2 2.3 2 0 0 2 2 2 1 Band 3 cytoplasmic domain PTS_EIIA_2 PF00359.20 MSTRG.2263.1_1 - 0.00011 22.0 0.0 0.00057 19.7 0.0 2.0 2 0 0 2 2 2 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 Dynactin_p62 PF05502.11 MSTRG.2263.1_1 - 0.61 8.7 2.7 1.3 7.6 2.7 1.4 1 0 0 1 1 1 0 Dynactin p62 family T2SSF PF00482.21 MSTRG.3667.1_2 - 0.076 12.8 0.1 0.57 10.0 0.0 2.0 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F RUN PF02759.17 MSTRG.11183.1_1 - 1.4e-30 105.9 0.0 2.8e-30 104.9 0.0 1.5 1 0 0 1 1 1 1 RUN domain FYVE PF01363.19 MSTRG.11183.1_1 - 1.8e-07 31.1 1.3 3.8e-07 30.0 1.3 1.5 1 0 0 1 1 1 1 FYVE zinc finger Trimer_CC PF08954.9 MSTRG.11183.1_1 - 0.00028 20.2 3.5 0.14 11.6 1.8 2.8 2 0 0 2 2 2 2 Trimerisation motif BLOC1_2 PF10046.7 MSTRG.11183.1_1 - 0.0075 16.4 15.9 0.41 10.8 4.8 3.0 2 1 0 2 2 2 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 Reo_sigmaC PF04582.10 MSTRG.11183.1_1 - 0.012 14.9 13.8 0.11 11.8 4.0 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein DUF1664 PF07889.10 MSTRG.11183.1_1 - 0.25 11.2 15.3 0.11 12.4 1.4 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF3209 PF11483.6 MSTRG.11183.1_1 - 0.69 10.3 6.9 1.7 9.0 0.1 2.8 3 0 0 3 3 2 0 Protein of unknown function (DUF3209) Cob_adeno_trans PF01923.16 MSTRG.11183.1_1 - 0.75 9.8 6.4 0.34 10.9 1.9 2.1 2 0 0 2 2 2 0 Cobalamin adenosyltransferase GIT_CC PF16559.3 MSTRG.11183.1_1 - 1 9.3 6.8 0.14 12.1 1.1 2.6 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor zf-RING_2 PF13639.4 MSTRG.11183.1_1 - 1.3 9.2 6.1 3 8.0 6.1 1.7 1 0 0 1 1 1 0 Ring finger domain DASH_Dam1 PF08653.8 MSTRG.11183.1_1 - 1.3 8.7 4.8 19 5.0 0.2 3.6 4 0 0 4 4 4 0 DASH complex subunit Dam1 NPV_P10 PF05531.10 MSTRG.11183.1_1 - 3.2 8.2 13.2 15 6.0 1.6 3.5 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein APG17 PF04108.10 MSTRG.11183.1_1 - 3.8 6.4 18.2 0.46 9.4 10.7 2.1 1 1 1 2 2 2 0 Autophagy protein Apg17 LPP PF04728.11 MSTRG.11183.1_1 - 4.4 7.6 15.6 2.2 8.6 1.4 3.2 2 2 1 3 3 3 0 Lipoprotein leucine-zipper bZIP_1 PF00170.19 MSTRG.11183.1_1 - 4.9 7.2 20.9 0.085 12.8 0.7 4.2 3 1 1 4 4 4 0 bZIP transcription factor SlyX PF04102.10 MSTRG.11183.1_1 - 5 7.7 23.0 15 6.2 0.5 4.5 3 1 1 4 4 4 0 SlyX BRE1 PF08647.9 MSTRG.11183.1_1 - 6.4 6.8 19.9 0.64 10.0 4.5 3.0 3 0 0 3 3 3 0 BRE1 E3 ubiquitin ligase PKcGMP_CC PF16808.3 MSTRG.11183.1_1 - 8.3 6.2 8.4 0.64 9.8 1.3 2.9 3 0 0 3 3 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Fib_alpha PF08702.8 MSTRG.11183.1_1 - 9.5 6.3 13.6 9.7 6.2 1.7 2.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family APG6 PF04111.10 MSTRG.15465.2_3 - 1.1e-126 422.3 7.9 1.5e-126 421.9 7.9 1.2 1 0 0 1 1 1 1 Autophagy protein Apg6 BH3 PF15285.4 MSTRG.15465.2_3 - 1.2e-16 59.9 0.2 2.2e-16 59.0 0.2 1.4 1 0 0 1 1 1 1 Beclin-1 BH3 domain, Bcl-2-interacting DUF342 PF03961.11 MSTRG.15465.2_3 - 0.075 11.5 12.5 0.13 10.7 11.6 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF342) SPAM PF02090.13 MSTRG.15465.2_3 - 0.8 9.4 14.6 1.3 8.7 14.1 1.5 1 1 0 1 1 1 0 Salmonella surface presentation of antigen gene type M protein DUF2968 PF11180.6 MSTRG.15465.2_3 - 0.83 9.2 15.9 1.5 8.3 15.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) IncA PF04156.12 MSTRG.15465.2_3 - 5.4 6.6 22.4 9.4 5.8 22.4 1.3 1 0 0 1 1 1 0 IncA protein Seryl_tRNA_N PF02403.20 MSTRG.15465.2_3 - 8.6 6.5 11.2 17 5.6 10.8 1.7 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain SOUL PF04832.10 MSTRG.312.1_2 - 1.5e-48 165.0 0.0 1.7e-48 164.8 0.0 1.0 1 0 0 1 1 1 1 SOUL heme-binding protein DUF4988 PF16378.3 MSTRG.312.1_2 - 0.032 13.7 0.2 0.049 13.1 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function Op_neuropeptide PF08035.9 MSTRG.312.1_2 - 0.065 13.0 0.5 0.2 11.4 0.5 1.9 1 0 0 1 1 1 0 Opioids neuropeptide GON PF08685.9 MSTRG.21600.1_3 - 1.6e-82 276.1 0.2 2.8e-82 275.3 0.2 1.4 1 0 0 1 1 1 1 GON domain TSP_1 PF00090.17 MSTRG.21600.1_3 - 0.47 10.6 10.8 1.6 8.8 10.8 2.0 1 0 0 1 1 1 0 Thrombospondin type 1 domain Shisa PF13908.4 MSTRG.457.1_1 - 1.7e-23 83.7 8.7 1.7e-23 83.7 8.7 1.9 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator Pkinase PF00069.23 MSTRG.18087.2_1 - 1.6e-19 70.1 0.0 2.3e-19 69.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.23 MSTRG.18087.2_2 - 3e-22 79.1 0.1 4.9e-22 78.4 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.18087.2_2 - 3.4e-08 32.9 0.1 5.1e-08 32.4 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.20 MSTRG.18087.2_2 - 0.08 12.4 0.2 0.15 11.5 0.2 1.4 1 0 0 1 1 1 0 RIO1 family DUF2011 PF09428.8 MSTRG.18087.2_2 - 6.2 6.7 10.7 7.9 6.3 1.3 2.3 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF2011) Pkinase PF00069.23 MSTRG.12059.1_2 - 7.2e-60 202.4 0.0 1.5e-59 201.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.12059.1_2 - 1.4e-34 119.5 0.0 3.4e-34 118.2 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Vir_act_alpha_C PF10400.7 MSTRG.12059.1_2 - 0.13 12.8 7.3 0.86 10.2 0.8 2.6 2 0 0 2 2 2 0 Virulence activator alpha C-term WH1 PF00568.21 MSTRG.4337.3_2 - 1e-36 125.1 0.0 1.7e-36 124.4 0.0 1.3 1 0 0 1 1 1 1 WH1 domain VASP_tetra PF08776.9 MSTRG.4337.3_2 - 7.8e-18 63.6 11.3 1.2e-17 63.0 11.3 1.3 1 0 0 1 1 1 1 VASP tetramerisation domain Ran_BP1 PF00638.16 MSTRG.4337.3_2 - 0.0057 16.8 0.0 0.014 15.5 0.0 1.6 1 0 0 1 1 1 1 RanBP1 domain Sec2p PF06428.9 MSTRG.25029.1_2 - 2.2e-08 33.8 9.5 2.2e-08 33.8 9.5 2.1 1 1 1 2 2 2 1 GDP/GTP exchange factor Sec2p DUF4407 PF14362.4 MSTRG.25029.1_2 - 0.059 12.6 7.4 0.11 11.7 6.6 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Spc7 PF08317.9 MSTRG.25029.1_2 - 0.09 11.5 10.9 0.13 11.0 10.9 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein HSP70 PF00012.18 MSTRG.25029.1_2 - 0.15 10.1 3.1 0.2 9.6 3.1 1.1 1 0 0 1 1 1 0 Hsp70 protein APG6 PF04111.10 MSTRG.25029.1_2 - 0.95 8.7 11.7 1.3 8.2 11.7 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 CC2-LZ PF16516.3 MSTRG.25029.1_2 - 2.5 8.3 12.7 1.8 8.8 6.3 2.2 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator UMPH-1 PF05822.10 MSTRG.3563.2_2 - 1e-121 405.0 0.6 1.3e-121 404.7 0.6 1.1 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD PF12710.5 MSTRG.3563.2_2 - 1e-05 25.9 0.0 1.5e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase OB_NTP_bind PF07717.14 MSTRG.10014.1_2 - 4.1e-09 36.4 0.0 7e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.21 MSTRG.10014.1_3 - 5.1e-19 68.4 0.0 1.2e-18 67.2 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.29 MSTRG.10014.1_3 - 2.1e-15 56.9 0.0 8.2e-15 55.0 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.27 MSTRG.10014.1_3 - 3.6e-11 43.0 0.1 6.1e-11 42.3 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.4 MSTRG.10014.1_3 - 7.5e-06 26.1 0.1 1.7e-05 25.0 0.1 1.6 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.20 MSTRG.10014.1_3 - 0.014 14.3 0.0 0.027 13.4 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain ATPase PF06745.11 MSTRG.10014.1_3 - 0.033 13.4 0.0 0.064 12.5 0.0 1.4 1 0 0 1 1 1 0 KaiC T2SSE PF00437.18 MSTRG.10014.1_3 - 0.051 12.5 0.3 0.11 11.4 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_14 PF13173.4 MSTRG.10014.1_3 - 0.066 13.1 0.0 2.5 8.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.4 MSTRG.10014.1_3 - 0.1 12.8 0.0 0.34 11.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain HMG14_17 PF01101.16 MSTRG.4325.1_3 - 1.2e-05 26.0 26.5 1.5e-05 25.7 26.5 1.1 1 0 0 1 1 1 1 HMG14 and HMG17 RR_TM4-6 PF06459.10 MSTRG.4325.1_3 - 2.1 7.9 15.8 2.9 7.5 15.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GST_N PF02798.18 MSTRG.4702.6_2 - 7.3e-13 48.5 0.0 1.4e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.4 MSTRG.4702.6_2 - 9.8e-12 45.0 0.0 1.7e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 MSTRG.4702.6_2 - 3.5e-10 39.9 0.0 6e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.4 MSTRG.4702.6_2 - 1.9e-06 27.8 0.0 3.3e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 MSTRG.4702.6_2 - 2.5e-06 27.5 0.0 4.5e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 MSTRG.4702.6_2 - 0.00075 19.3 0.0 0.0029 17.4 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain SpoIID PF08486.8 MSTRG.5925.3_2 - 0.19 12.2 0.7 0.55 10.7 0.2 2.0 2 0 0 2 2 2 0 Stage II sporulation protein 2-Hacid_dh_C PF02826.17 MSTRG.10331.4_3 - 1.4e-55 187.3 0.0 1.9e-55 186.8 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.28 MSTRG.10331.4_3 - 2.2e-27 95.2 0.0 3e-27 94.8 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.13 MSTRG.10331.4_3 - 0.00015 21.9 0.0 0.00025 21.1 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NIF PF03031.16 MSTRG.25096.1_3 - 2.4e-53 180.0 0.9 3.6e-53 179.4 0.9 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Voltage_CLC PF00654.18 MSTRG.25848.3_2 - 5.9e-110 367.7 21.3 8.7e-110 367.1 21.3 1.2 1 0 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.26 MSTRG.25848.3_2 - 3.7e-12 46.4 0.5 1e-06 29.0 0.1 2.4 2 0 0 2 2 2 2 CBS domain Ldl_recept_a PF00057.16 MSTRG.15543.1_3 - 1.7e-13 50.4 14.2 2.5e-13 49.9 14.2 1.3 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Carn_acyltransf PF00755.18 MSTRG.20772.1_1 - 4.2e-167 557.1 0.0 4.9e-167 556.9 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase PAP2 PF01569.19 MSTRG.1929.1_2 - 0.0002 21.0 0.1 0.00045 19.9 0.0 1.6 2 0 0 2 2 2 1 PAP2 superfamily BTB_2 PF02214.20 MSTRG.437.2_1 - 5.9e-22 77.7 0.1 1.1e-21 76.9 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain S1 PF00575.21 MSTRG.19047.2_2 - 4.4e-58 193.4 7.5 2.1e-11 43.8 0.1 13.1 13 1 0 13 13 13 6 S1 RNA binding domain TPR_19 PF14559.4 MSTRG.19047.2_2 - 2.4e-11 43.9 0.1 8e-05 23.0 0.1 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.19047.2_2 - 8.9e-08 32.2 2.7 0.19 12.5 0.1 5.3 2 2 3 5 5 5 2 Tetratricopeptide repeat Suf PF05843.12 MSTRG.19047.2_2 - 2.8e-07 30.7 24.8 0.00023 21.1 0.7 4.4 1 1 2 4 4 3 3 Suppressor of forked protein (Suf) TPR_16 PF13432.4 MSTRG.19047.2_2 - 1.2e-05 25.7 0.2 0.0055 17.2 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.4 MSTRG.19047.2_2 - 0.002 17.3 0.5 0.002 17.3 0.5 2.7 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.19047.2_2 - 0.0037 17.4 0.2 9.9 6.4 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.19047.2_2 - 0.0042 17.1 0.2 0.87 9.8 0.1 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat PPR PF01535.18 MSTRG.19047.2_2 - 0.0055 16.7 0.1 0.11 12.7 0.1 3.0 3 0 0 3 3 3 1 PPR repeat PCB_OB PF17092.3 MSTRG.19047.2_2 - 0.0097 16.5 0.0 1.5 9.5 0.0 4.2 3 0 0 3 3 3 1 Penicillin-binding protein OB-like domain TPR_2 PF07719.15 MSTRG.19047.2_2 - 0.053 13.5 1.2 46 4.3 0.0 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Wzy_C_2 PF11846.6 MSTRG.19047.2_2 - 0.084 12.7 2.5 0.34 10.7 2.4 2.0 1 1 1 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal TPR_6 PF13174.4 MSTRG.19047.2_2 - 0.11 13.0 3.0 8.6 7.1 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.4 MSTRG.19047.2_2 - 0.14 12.1 0.0 0.82 9.7 0.0 2.4 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF4770 PF15994.3 MSTRG.19047.2_2 - 5.4 7.1 9.6 15 5.7 2.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) JmjC PF02373.20 MSTRG.5294.1_3 - 2.4e-27 95.5 0.0 5.1e-27 94.5 0.0 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.4 MSTRG.5294.1_3 - 1.1e-17 64.5 0.1 2.3e-17 63.5 0.1 1.5 1 0 0 1 1 1 1 Cupin-like domain IMUP PF15761.3 MSTRG.5294.1_3 - 0.0022 18.5 10.0 0.0022 18.5 10.0 2.0 2 0 0 2 2 2 1 Immortalisation up-regulated protein AF-4 PF05110.11 MSTRG.5294.1_3 - 0.45 8.4 13.2 0.8 7.6 13.2 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SR-25 PF10500.7 MSTRG.5294.1_3 - 0.58 9.6 20.1 0.026 14.0 7.0 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF1669 PF07894.10 MSTRG.6395.3_3 - 1.6e-110 368.9 0.0 2.6e-110 368.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1669) PLDc_2 PF13091.4 MSTRG.6395.3_3 - 1.4e-06 28.1 0.0 2.5e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 PLD-like domain LIM PF00412.20 MSTRG.22872.2_1 - 0.55 10.4 13.5 1.2 9.3 13.5 1.6 1 0 0 1 1 1 0 LIM domain BTB PF00651.29 MSTRG.2081.1_1 - 2.8e-23 82.1 0.3 4.9e-23 81.3 0.3 1.3 1 0 0 1 1 1 1 BTB/POZ domain BEN PF10523.7 MSTRG.2081.1_1 - 1.2e-08 34.9 0.1 2.6e-08 33.9 0.1 1.5 1 0 0 1 1 1 1 BEN domain SelP_N PF04592.12 MSTRG.2081.1_3 - 9.4 5.4 15.3 18 4.5 15.3 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PA26 PF04636.11 MSTRG.8036.1_1 - 3e-156 520.6 0.0 3.7e-156 520.3 0.0 1.1 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) MOR2-PAG1_C PF14225.4 MSTRG.7196.1_1 - 3.3e-71 240.0 12.9 3.5e-71 239.9 8.6 2.8 2 0 0 2 2 2 1 Cell morphogenesis C-terminal MOR2-PAG1_N PF14222.4 MSTRG.7196.1_1 - 7.6e-66 223.1 0.1 1.5e-65 222.0 0.1 1.6 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_mid PF14228.4 MSTRG.7196.1_1 - 2.1e-27 95.2 5.0 2.1e-10 38.9 0.0 6.4 5 1 0 6 6 6 5 Cell morphogenesis central region BSP_II PF05432.9 MSTRG.7196.1_1 - 2.6 7.6 7.7 4.9 6.6 7.7 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) PhoLip_ATPase_C PF16212.3 MSTRG.3357.2_1 - 2.5e-73 246.8 25.9 2.5e-73 246.8 25.9 2.0 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.3 MSTRG.3357.2_1 - 4.7e-23 80.6 0.2 4.7e-23 80.6 0.2 2.7 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.18 MSTRG.3357.2_1 - 4.8e-10 39.0 0.0 4.8e-10 39.0 0.0 2.3 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.24 MSTRG.3357.2_1 - 6.1e-09 36.3 0.0 0.00014 22.1 0.0 3.2 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.4 MSTRG.3357.2_1 - 3.7e-08 33.2 0.0 1e-07 31.8 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) HAD PF12710.5 MSTRG.3357.2_1 - 0.053 13.8 0.2 0.55 10.5 0.2 2.7 4 0 0 4 4 4 0 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.10 MSTRG.3357.2_1 - 0.056 13.0 0.0 0.45 10.1 0.0 2.1 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase PAP2 PF01569.19 MSTRG.399.1_3 - 3.3e-17 62.4 4.1 1e-16 60.8 4.1 1.9 1 0 0 1 1 1 1 PAP2 superfamily Pannexin_like PF12534.6 MSTRG.21474.1_3 - 6.2e-157 522.0 2.7 9.3e-157 521.4 2.7 1.3 1 0 0 1 1 1 1 Pannexin-like TM region of LRRC8 LRR_8 PF13855.4 MSTRG.21474.1_3 - 3.6e-26 90.6 26.0 2.5e-09 36.6 3.6 7.3 3 3 5 8 8 8 7 Leucine rich repeat LRR_4 PF12799.5 MSTRG.21474.1_3 - 4e-23 80.9 37.3 6.2e-07 29.5 0.3 8.6 4 2 7 11 11 11 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 MSTRG.21474.1_3 - 1.3e-07 31.2 12.4 0.00025 20.5 1.1 3.6 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.31 MSTRG.21474.1_3 - 0.00026 20.9 33.7 0.21 12.0 1.1 10.0 8 3 0 8 8 8 2 Leucine Rich Repeat 7tm_7 PF08395.10 MSTRG.21474.1_3 - 0.0057 15.8 3.5 0.0057 15.8 3.5 2.6 3 0 0 3 3 3 1 7tm Chemosensory receptor DEAD PF00270.27 MSTRG.26030.1_1 - 7e-49 165.8 0.0 2.8e-48 163.9 0.0 1.8 1 1 1 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 MSTRG.26030.1_1 - 5.8e-31 107.0 0.0 1.4e-30 105.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 MSTRG.26030.1_1 - 0.0013 18.6 0.0 0.0033 17.3 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.3 MSTRG.26030.1_1 - 0.037 13.1 0.0 0.058 12.5 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase AAA_19 PF13245.4 MSTRG.26030.1_1 - 0.14 12.3 0.0 8.2 6.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain LSR PF05624.12 MSTRG.17495.1_2 - 1.1e-22 79.7 36.9 1.5e-22 79.2 36.9 1.2 1 0 0 1 1 1 1 Lipolysis stimulated receptor (LSR) Phage_tail_NK PF16532.3 MSTRG.17495.1_2 - 0.2 11.1 0.3 0.28 10.7 0.3 1.2 1 0 0 1 1 1 0 Sf6-type phage tail needle knob or tip of some Caudovirales ENOD93 PF03386.12 MSTRG.12724.1_2 - 0.049 13.4 0.8 0.24 11.2 0.0 2.1 2 0 0 2 2 2 0 Early nodulin 93 ENOD93 protein RepA1_leader PF08048.10 MSTRG.18530.2_1 - 0.092 12.9 0.3 0.2 11.8 0.3 1.5 1 0 0 1 1 1 0 Tap RepA1 leader peptide Pribosyl_synth PF14572.4 MSTRG.6400.1_2 - 6.3e-98 326.1 0.5 1.2e-97 325.2 0.5 1.5 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.4 MSTRG.6400.1_2 - 1.4e-36 124.8 0.3 2.6e-36 123.9 0.3 1.5 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.25 MSTRG.6400.1_2 - 9.6e-05 21.8 0.7 0.00024 20.5 0.2 1.9 2 1 0 2 2 2 1 Phosphoribosyl transferase domain TPR_19 PF14559.4 MSTRG.25335.1_2 - 1.6e-06 28.4 2.0 0.011 16.1 0.2 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.4 MSTRG.25335.1_2 - 3.6e-05 23.5 5.0 0.13 12.5 0.1 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.26 MSTRG.25335.1_2 - 5.4e-05 22.7 11.3 0.2 11.4 0.2 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.4 MSTRG.25335.1_2 - 6.3e-05 23.0 2.1 0.23 11.8 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.4 MSTRG.25335.1_2 - 0.00013 21.5 0.0 0.74 9.4 0.0 3.8 4 0 0 4 4 4 2 TPR repeat TPR_2 PF07719.15 MSTRG.25335.1_2 - 0.00034 20.4 14.9 0.79 9.9 0.1 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.4 MSTRG.25335.1_2 - 0.0082 16.3 1.9 3.5 7.9 0.1 3.7 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.4 MSTRG.25335.1_2 - 0.015 15.8 0.2 1.1e+02 3.4 0.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.4 MSTRG.25335.1_2 - 0.099 13.4 7.1 4.9 8.1 0.1 4.7 3 2 2 5 5 5 0 Tetratricopeptide repeat Prenyltrans PF00432.19 MSTRG.25335.1_3 - 0.078 12.6 0.7 0.24 11.0 0.7 1.8 1 0 0 1 1 1 0 Prenyltransferase and squalene oxidase repeat BLOC1S3 PF15753.3 MSTRG.17016.1_1 - 1.5e-67 226.9 3.4 1.7e-67 226.7 3.4 1.0 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex 1 subunit 3 Arm PF00514.21 MSTRG.21870.1_1 - 1.7e-11 43.6 0.1 5.4e-11 42.0 0.0 1.7 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat GoLoco PF02188.15 MSTRG.21870.1_2 - 0.11 11.8 1.2 0.11 11.8 1.2 1.6 2 0 0 2 2 2 0 GoLoco motif DUF3477 PF11963.6 MSTRG.29224.1_1 - 0.15 11.1 0.0 0.18 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3477) Nckap1 PF09735.7 MSTRG.29224.1_2 - 2.7e-10 38.8 0.2 3.3e-10 38.5 0.2 1.1 1 0 0 1 1 1 1 Membrane-associated apoptosis protein FAM110_N PF14161.4 MSTRG.9229.1_2 - 0.094 12.8 0.1 0.21 11.7 0.0 1.5 2 0 0 2 2 2 0 Centrosome-associated N terminus Sec23_trunk PF04811.13 MSTRG.19032.1_3 - 6.9e-78 261.4 0.0 1e-77 260.9 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.10 MSTRG.19032.1_3 - 4.9e-32 110.4 0.6 1.2e-31 109.2 0.1 1.9 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.13 MSTRG.19032.1_3 - 1.7e-25 88.7 0.1 4.3e-25 87.4 0.1 1.8 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Gelsolin PF00626.20 MSTRG.19032.1_3 - 2.9e-15 55.8 0.0 7.4e-15 54.5 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat zf-Sec23_Sec24 PF04810.13 MSTRG.19032.1_3 - 1.7e-14 53.4 7.1 1.7e-14 53.4 7.1 1.8 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger APP_E2 PF12925.5 MSTRG.19032.1_3 - 0.012 15.2 0.0 0.031 13.8 0.0 1.6 2 0 0 2 2 2 0 E2 domain of amyloid precursor protein SNF PF00209.16 MSTRG.18686.1_3 - 2.1e-57 194.9 6.5 2.9e-57 194.4 6.5 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family FtsX PF02687.19 MSTRG.18686.1_3 - 1.4 8.8 14.9 0.12 12.2 1.6 2.8 3 0 0 3 3 3 0 FtsX-like permease family DUF3338 PF11819.6 MSTRG.18503.1_1 - 8.6e-42 142.2 0.9 1.4e-41 141.6 0.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3338) FERM_C PF09380.8 MSTRG.18503.1_1 - 3.4e-14 52.9 0.6 5.8e-14 52.1 0.6 1.3 1 0 0 1 1 1 1 FERM C-terminal PH-like domain DUF4175 PF13779.4 MSTRG.18503.1_1 - 0.032 12.0 0.4 0.039 11.7 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF3079 PF11278.6 MSTRG.18503.1_2 - 0.24 11.1 4.5 0.65 9.7 0.4 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3079) DUF4506 PF14958.4 MSTRG.10157.2_2 - 5.5e-38 129.5 0.0 8.1e-38 129.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4506) XhlA PF10779.7 MSTRG.10157.2_2 - 0.06 13.4 0.9 0.11 12.5 0.9 1.4 1 0 0 1 1 1 0 Haemolysin XhlA Pyridoxal_deC PF00282.17 MSTRG.15713.1_1 - 1.1e-15 57.2 0.1 1.1e-15 57.1 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Gal-bind_lectin PF00337.20 MSTRG.27311.1_1 - 3.8e-77 256.2 1.1 2.7e-38 130.4 0.0 2.2 2 0 0 2 2 2 2 Galactoside-binding lectin Cytadhesin_P30 PF07271.9 MSTRG.27311.1_1 - 0.00016 21.2 16.3 0.00037 20.0 16.3 1.6 1 0 0 1 1 1 1 Cytadhesin P30/P32 Pericardin_rpt PF07054.9 MSTRG.27311.1_1 - 0.028 14.4 21.5 0.03 14.3 13.4 2.7 1 1 1 2 2 2 0 Pericardin like repeat TPT PF03151.14 MSTRG.17564.3_2 - 1.3e-17 64.0 9.2 1.6e-17 63.7 9.2 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.18 MSTRG.17564.3_2 - 9.4e-07 28.9 12.8 0.0023 18.0 7.8 2.4 2 0 0 2 2 2 2 EamA-like transporter family Ras PF00071.20 MSTRG.8682.2_2 - 4.2e-43 146.6 0.0 6e-43 146.1 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 MSTRG.8682.2_2 - 6.4e-22 77.9 0.0 9.5e-22 77.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 MSTRG.8682.2_2 - 9e-07 28.4 0.0 1.4e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 MSTRG.8682.2_2 - 0.0094 15.9 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.25 MSTRG.8682.2_2 - 0.065 13.6 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.4 MSTRG.8682.2_2 - 0.068 13.4 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.12 MSTRG.8682.2_2 - 0.13 12.2 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) SRPRB PF09439.8 MSTRG.8682.2_2 - 0.16 11.3 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Ras PF00071.20 MSTRG.8682.2_3 - 0.0066 15.9 0.1 0.0093 15.4 0.1 1.2 1 0 0 1 1 1 1 Ras family Integrase_AP2 PF14657.4 MSTRG.8682.2_3 - 0.2 11.3 4.4 0.42 10.3 4.4 1.5 1 0 0 1 1 1 0 AP2-like DNA-binding integrase domain DUF4746 PF15928.3 MSTRG.24181.2_2 - 0.029 13.7 0.2 0.046 13.0 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Arf PF00025.19 MSTRG.24181.2_3 - 4.4e-75 250.8 0.2 5.9e-75 250.4 0.2 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 MSTRG.24181.2_3 - 1e-12 48.2 0.1 1.5e-12 47.7 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 MSTRG.24181.2_3 - 1.5e-12 47.2 0.0 2.2e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 MSTRG.24181.2_3 - 6e-11 42.0 0.9 4.5e-08 32.5 0.1 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.20 MSTRG.24181.2_3 - 7.5e-11 41.8 0.0 1.1e-10 41.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.10 MSTRG.24181.2_3 - 1.3e-09 37.6 0.0 1.9e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 MSTRG.24181.2_3 - 0.0029 17.6 0.0 0.0053 16.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.16 MSTRG.24181.2_3 - 0.083 12.1 0.1 0.14 11.3 0.1 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase CbiA PF01656.21 MSTRG.24181.2_3 - 0.098 12.6 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Mad3_BUB1_I PF08311.10 MSTRG.7590.2_2 - 1.9e-41 140.8 0.8 2.9e-41 140.2 0.8 1.3 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Mad3_BUB1_I_2 PF17014.3 MSTRG.7590.2_2 - 0.00073 19.5 0.0 0.0013 18.8 0.0 1.3 1 0 0 1 1 1 1 Putative Mad3/BUB1 like region 1 protein zf-H2C2_2 PF13465.4 MSTRG.24258.1_2 - 6.7e-51 168.4 56.1 6.7e-09 35.7 0.3 9.3 8 1 1 9 9 9 7 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.24258.1_2 - 1.2e-39 132.5 62.2 2.7e-06 27.4 1.0 8.5 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.24258.1_2 - 3.5e-29 98.8 58.3 2.5e-05 24.6 0.7 8.5 8 0 0 8 8 8 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.24258.1_2 - 2.5e-15 55.9 46.4 0.0006 19.6 0.3 8.2 8 0 0 8 8 8 6 C2H2-type zinc finger zf-met PF12874.5 MSTRG.24258.1_2 - 3.5e-10 39.8 48.1 0.0044 17.2 0.3 8.3 8 0 0 8 8 8 5 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.24258.1_2 - 1.5e-07 31.4 20.1 0.75 10.1 0.1 7.1 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 MSTRG.24258.1_2 - 3.9e-06 26.4 49.0 0.15 11.7 0.8 8.1 8 0 0 8 8 8 4 zinc-finger C2H2-type zf-Di19 PF05605.10 MSTRG.24258.1_2 - 0.0004 20.5 27.8 0.013 15.6 0.8 5.3 1 1 6 7 7 7 5 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_15 PF17032.3 MSTRG.24258.1_2 - 0.00083 19.9 29.0 0.18 12.5 0.5 5.1 2 1 2 5 5 4 3 zinc-ribbon family LIM PF00412.20 MSTRG.24258.1_2 - 0.0011 19.0 28.2 0.8 9.9 1.7 7.1 1 1 6 7 7 7 1 LIM domain Zn-ribbon_8 PF09723.8 MSTRG.24258.1_2 - 0.017 15.1 35.1 0.69 9.9 2.9 7.0 2 2 5 7 7 7 0 Zinc ribbon domain DUF3268 PF11672.6 MSTRG.24258.1_2 - 0.026 14.7 9.1 0.6 10.3 0.4 3.7 3 0 0 3 3 3 0 zinc-finger-containing domain Elf1 PF05129.11 MSTRG.24258.1_2 - 0.029 14.3 2.3 0.029 14.3 2.3 4.9 1 1 5 6 6 6 0 Transcription elongation factor Elf1 like HypA PF01155.17 MSTRG.24258.1_2 - 0.15 11.9 25.7 5.3 7.0 2.9 5.4 1 1 4 5 5 5 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ADK_lid PF05191.12 MSTRG.24258.1_2 - 0.17 11.8 15.6 1.7 8.6 1.3 5.7 4 3 1 5 5 5 0 Adenylate kinase, active site lid zf-C2HC_2 PF13913.4 MSTRG.24258.1_2 - 0.4 10.5 35.3 0.42 10.5 0.1 7.5 7 1 1 8 8 8 0 zinc-finger of a C2HC-type zf-C2H2_2 PF12756.5 MSTRG.24258.1_2 - 0.43 10.8 30.2 6.1 7.1 3.2 6.9 1 1 6 7 7 7 0 C2H2 type zinc-finger (2 copies) zf-C2HE PF16278.3 MSTRG.24258.1_2 - 0.77 10.1 36.8 10 6.5 0.7 8.4 2 2 3 5 5 4 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_9 PF16293.3 MSTRG.24258.1_2 - 0.8 9.5 5.6 41 4.0 0.0 4.3 5 0 0 5 5 4 0 C2H2 type zinc-finger (1 copy) Siva PF05458.10 MSTRG.24258.1_2 - 0.98 8.9 21.1 2.5 7.6 5.2 3.6 1 1 2 3 3 3 0 Cd27 binding protein (Siva) BolA PF01722.16 MSTRG.24258.1_2 - 1.8 8.7 13.8 6.9 6.9 0.4 5.1 2 2 4 6 6 6 0 BolA-like protein zf-trcl PF13451.4 MSTRG.24258.1_2 - 2.3 8.1 28.8 2 8.2 0.2 7.6 8 0 0 8 8 8 0 Probable zinc-ribbon domain DUF2180 PF09947.7 MSTRG.24258.1_2 - 3.5 7.5 13.4 3.3 7.6 0.9 4.4 3 1 2 5 5 5 0 Uncharacterized protein conserved in archaea (DUF2180) zf-LYAR PF08790.9 MSTRG.24258.1_2 - 5.5 6.9 35.6 0.53 10.1 1.5 7.9 8 0 0 8 8 8 0 LYAR-type C2HC zinc finger DUF1163 PF06651.9 MSTRG.24258.1_2 - 6.4 6.8 10.7 17 5.5 0.1 4.0 2 2 2 4 4 4 0 Protein of unknown function (DUF1163) Colicin_V PF02674.14 MSTRG.16962.1_3 - 0.8 9.5 13.1 4.1 7.2 0.4 2.7 2 1 0 2 2 2 0 Colicin V production protein GtrA PF04138.12 MSTRG.16962.1_3 - 5.2 7.2 15.4 3.2 7.9 7.2 2.3 2 0 0 2 2 2 0 GtrA-like protein Peptidase_M20 PF01546.26 MSTRG.13892.2_1 - 5.9e-34 117.4 0.0 7.6e-34 117.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.12 MSTRG.13892.2_1 - 6.4e-15 54.9 0.0 1.1e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.15 MSTRG.13892.2_1 - 8.6e-05 22.2 0.0 0.0076 15.8 0.0 2.2 2 0 0 2 2 2 2 Peptidase family M28 Rad51 PF08423.9 MSTRG.16406.1_3 - 6.2e-41 140.2 0.0 8.8e-41 139.7 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.4 MSTRG.16406.1_3 - 7.6e-09 35.3 0.0 1.8e-08 34.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain ATPase PF06745.11 MSTRG.16406.1_3 - 6e-06 25.6 0.0 3e-05 23.3 0.0 1.9 1 1 1 2 2 2 1 KaiC AAA_16 PF13191.4 MSTRG.16406.1_3 - 0.0013 19.0 2.0 0.045 14.0 0.1 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.4 MSTRG.16406.1_3 - 0.0021 18.2 0.0 0.0046 17.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain RNA_pol_A_CTD PF03118.13 MSTRG.16406.1_3 - 0.015 14.9 0.0 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain RecA PF00154.19 MSTRG.16406.1_3 - 0.029 13.7 0.0 0.1 11.9 0.0 1.8 2 0 0 2 2 2 0 recA bacterial DNA recombination protein NACHT PF05729.10 MSTRG.16406.1_3 - 0.077 12.8 0.1 0.17 11.7 0.1 1.6 1 1 0 1 1 1 0 NACHT domain IGFBP PF00219.16 MSTRG.1800.1_2 - 1.7e-08 34.8 20.8 3e-08 34.1 20.8 1.4 1 0 0 1 1 1 1 Insulin-like growth factor binding protein PNRC PF15365.4 MSTRG.19197.3_1 - 6.5 7.3 9.4 0.19 12.2 2.1 2.4 2 0 0 2 2 2 0 Proline-rich nuclear receptor coactivator Calreticulin PF00262.16 MSTRG.19197.3_3 - 1.3e-161 537.4 14.4 1.3e-161 537.4 14.4 1.7 2 0 0 2 2 2 1 Calreticulin family Folate_carrier PF01770.16 MSTRG.19197.3_3 - 0.081 11.5 2.8 0.15 10.6 0.0 2.4 3 0 0 3 3 3 0 Reduced folate carrier Abhydrolase_6 PF12697.5 MSTRG.13473.3_3 - 0.11 13.0 0.0 0.14 12.7 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Pkinase_Tyr PF07714.15 MSTRG.1304.1_2 - 5.5e-86 287.9 0.0 7.1e-86 287.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 MSTRG.1304.1_2 - 5.5e-39 134.0 0.0 7.4e-39 133.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.4 MSTRG.1304.1_2 - 0.0017 17.6 0.0 0.046 12.9 0.0 2.2 2 0 0 2 2 2 1 Kinase-like GCN5L1 PF06320.11 MSTRG.1414.1_1 - 3.4e-47 159.2 5.8 5.1e-47 158.6 5.8 1.3 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) RecT PF03837.12 MSTRG.1414.1_1 - 0.039 13.3 0.0 0.056 12.8 0.0 1.2 1 0 0 1 1 1 0 RecT family GSCFA PF08885.9 MSTRG.1414.1_1 - 0.039 13.5 0.9 0.056 13.0 0.9 1.2 1 0 0 1 1 1 0 GSCFA family BRD4_CDT PF17105.3 MSTRG.1414.1_1 - 0.069 12.6 3.7 0.82 9.2 5.2 1.9 2 0 0 2 2 2 0 C-terminal domain of bromodomain protein 4 Complex1_49kDa PF00346.17 MSTRG.3291.1_1 - 9.4e-25 87.1 0.0 1.1e-24 86.9 0.0 1.0 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit Kinesin PF00225.21 MSTRG.10982.3_3 - 1.1e-105 353.1 0.0 1.1e-105 353.1 0.0 1.6 2 0 0 2 2 2 1 Kinesin motor domain MKLP1_Arf_bdg PF16540.3 MSTRG.10982.3_3 - 1.8e-42 143.6 2.1 2.7e-42 143.0 0.0 2.3 2 0 0 2 2 2 1 Arf6-interacting domain of mitotic kinesin-like protein 1 Microtub_bd PF16796.3 MSTRG.10982.3_3 - 4.8e-21 75.1 0.0 2.2e-17 63.2 0.0 2.7 1 1 0 2 2 2 2 Microtubule binding FPP PF05911.9 MSTRG.10982.3_3 - 0.00034 18.9 17.4 0.00051 18.3 17.4 1.2 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil ERM PF00769.17 MSTRG.10982.3_3 - 0.023 14.4 17.8 0.049 13.3 17.8 1.5 1 0 0 1 1 1 0 Ezrin/radixin/moesin family ADIP PF11559.6 MSTRG.10982.3_3 - 0.06 13.3 28.0 0.32 10.9 25.6 3.1 3 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding DUF4618 PF15397.4 MSTRG.10982.3_3 - 3.5 6.9 25.7 0.089 12.1 15.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) Fez1 PF06818.13 MSTRG.10982.3_3 - 8.4 6.7 26.0 3 8.1 23.0 1.8 2 0 0 2 2 2 0 Fez1 ATP-gua_Ptrans PF00217.17 MSTRG.3751.2_1 - 4.8e-95 317.7 0.0 6.3e-95 317.3 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.13 MSTRG.3751.2_1 - 2e-30 104.9 0.0 3.9e-30 103.9 0.0 1.5 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain Mre11_DNA_bind PF04152.12 MSTRG.18044.1_2 - 6.7e-46 156.6 0.7 6.7e-46 156.6 0.7 1.8 2 0 0 2 2 2 1 Mre11 DNA-binding presumed domain Metallophos PF00149.26 MSTRG.18044.1_2 - 6.8e-16 59.3 1.2 1.1e-15 58.6 1.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF4194 PF13835.4 MSTRG.18044.1_2 - 0.022 14.3 1.1 0.29 10.7 2.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4194) zf-H2C2_2 PF13465.4 MSTRG.3281.1_1 - 3.4e-09 36.6 6.0 3.6e-06 27.0 1.0 2.9 2 0 0 2 2 2 2 Zinc-finger double domain BolA PF01722.16 MSTRG.3281.1_1 - 0.016 15.4 2.2 0.027 14.6 1.2 2.0 2 0 0 2 2 2 0 BolA-like protein DUF2197 PF09963.7 MSTRG.3281.1_1 - 0.095 12.8 0.8 0.22 11.7 0.8 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2197) zf-C2H2_4 PF13894.4 MSTRG.3281.1_1 - 0.3 11.9 3.4 0.52 11.1 0.6 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger zf-H2C2_2 PF13465.4 MSTRG.3281.1_3 - 1.7e-09 37.6 4.3 3.5e-05 23.9 0.3 3.3 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.3281.1_3 - 0.0013 19.3 11.0 0.048 14.4 0.5 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.24 MSTRG.3281.1_3 - 0.0017 18.6 13.5 0.046 14.1 0.8 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type DZR PF12773.5 MSTRG.3281.1_3 - 0.0042 16.9 0.8 0.011 15.5 0.8 1.8 1 0 0 1 1 1 1 Double zinc ribbon zf-Di19 PF05605.10 MSTRG.3281.1_3 - 0.0083 16.3 1.1 0.021 15.0 1.1 1.7 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_2 PF13240.4 MSTRG.3281.1_3 - 0.014 15.0 1.4 1.9 8.2 0.2 2.8 2 0 0 2 2 2 0 zinc-ribbon domain zf-ribbon_3 PF13248.4 MSTRG.3281.1_3 - 0.071 12.4 1.9 9.4 5.7 0.2 2.5 2 0 0 2 2 2 0 zinc-ribbon domain Nudix_N_2 PF14803.4 MSTRG.3281.1_3 - 0.36 10.7 4.6 12 5.8 0.1 3.5 4 0 0 4 4 4 0 Nudix N-terminal FixQ PF05545.9 MSTRG.18472.3_2 - 9.7 6.1 6.3 1.2 9.1 0.3 2.2 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ DUF1151 PF06625.9 MSTRG.18472.3_3 - 7.3e-44 148.2 25.0 1.1e-43 147.7 25.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1151) RNase_T PF00929.22 MSTRG.3542.1_2 - 1.3e-13 51.6 0.0 3e-13 50.5 0.0 1.6 2 0 0 2 2 2 1 Exonuclease zf-H2C2_2 PF13465.4 MSTRG.4963.2_1 - 5.1e-24 83.4 32.9 4e-09 36.4 1.8 6.0 6 0 0 6 6 5 3 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.4963.2_1 - 4.1e-21 74.1 22.9 1.3e-05 25.2 0.3 4.9 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 MSTRG.4963.2_1 - 5.6e-16 57.7 27.3 0.00046 20.6 0.5 5.1 5 0 0 5 5 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.4 MSTRG.4963.2_1 - 3e-09 36.5 15.8 0.0039 17.0 0.8 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger zf-Di19 PF05605.10 MSTRG.4963.2_1 - 1.2e-07 31.8 7.6 0.0033 17.6 2.0 2.6 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.5 MSTRG.4963.2_1 - 2.3e-07 30.9 16.0 0.0078 16.4 1.1 4.6 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.4 MSTRG.4963.2_1 - 4.6e-06 26.1 16.1 0.56 9.9 0.1 4.7 4 1 0 4 4 4 4 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.5 MSTRG.4963.2_1 - 4e-05 23.8 12.7 1.7 8.9 0.6 4.3 1 1 3 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-BED PF02892.13 MSTRG.4963.2_1 - 0.0001 22.1 20.4 0.17 11.8 1.3 4.5 1 1 3 4 4 4 3 BED zinc finger zf-C2H2_jaz PF12171.6 MSTRG.4963.2_1 - 0.00094 19.3 5.2 0.28 11.4 0.1 4.3 4 1 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-C4_ClpX PF06689.11 MSTRG.4963.2_1 - 0.0088 15.8 10.7 2.1 8.2 1.4 3.8 3 1 0 3 3 3 2 ClpX C4-type zinc finger Zn-ribbon_8 PF09723.8 MSTRG.4963.2_1 - 0.016 15.1 5.3 3.7 7.6 0.6 3.6 3 0 0 3 3 3 0 Zinc ribbon domain DUF2180 PF09947.7 MSTRG.4963.2_1 - 0.025 14.4 4.0 1.4 8.8 0.3 2.9 1 1 2 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2180) LIM PF00412.20 MSTRG.4963.2_1 - 0.069 13.3 9.7 0.61 10.2 0.2 3.5 1 1 2 3 3 3 0 LIM domain BolA PF01722.16 MSTRG.4963.2_1 - 0.082 13.1 1.3 0.6 10.3 0.2 2.6 1 1 2 3 3 3 0 BolA-like protein Elf1 PF05129.11 MSTRG.4963.2_1 - 0.42 10.6 10.8 1.4 8.9 4.4 2.9 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf-FCS PF06467.12 MSTRG.4963.2_1 - 1.5 8.8 10.0 8 6.4 2.0 3.5 1 1 2 3 3 3 0 MYM-type Zinc finger with FCS sequence motif zf-AN1 PF01428.14 MSTRG.4963.2_1 - 1.9 8.6 13.2 12 6.0 0.2 4.5 4 0 0 4 4 4 0 AN1-like Zinc finger DUF4757 PF15949.3 MSTRG.27536.5_2 - 3.8e-36 125.0 14.7 6.5e-35 121.0 10.2 5.9 5 1 0 5 5 5 2 Domain of unknown function (DUF4757) CH PF00307.29 MSTRG.27536.5_2 - 6.1e-11 42.3 0.0 1.3e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain LIM PF00412.20 MSTRG.27536.5_2 - 4e-07 30.0 0.8 1.1e-06 28.6 0.8 1.9 1 0 0 1 1 1 1 LIM domain Fil_haemagg_2 PF13332.4 MSTRG.27536.5_2 - 5.3 7.0 7.5 10 6.0 7.5 1.4 1 0 0 1 1 1 0 Haemagluttinin repeat Ig_3 PF13927.4 MSTRG.4318.4_2 - 2.6e-08 34.2 0.0 0.012 16.1 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 MSTRG.4318.4_2 - 0.00064 19.6 0.0 0.032 14.2 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin I-set domain SIT PF15330.4 MSTRG.4318.4_3 - 0.046 14.0 0.0 0.086 13.1 0.0 1.3 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Sulfatase PF00884.21 MSTRG.11320.1_2 - 1.7e-79 267.3 0.0 2.1e-79 267.0 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.4 MSTRG.11320.1_2 - 4.5e-33 114.5 0.0 7e-33 113.8 0.0 1.3 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.20 MSTRG.11320.1_2 - 2e-07 30.8 0.0 1.1e-06 28.4 0.0 1.9 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Glyco_tran_WecB PF03808.11 MSTRG.11320.1_3 - 0.19 11.6 0.9 0.29 10.9 0.9 1.2 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family TRAM_LAG1_CLN8 PF03798.14 MSTRG.18812.1_3 - 5.5e-41 140.4 16.8 8.1e-41 139.8 16.8 1.3 1 0 0 1 1 1 1 TLC domain Homeobox PF00046.27 MSTRG.18812.1_3 - 0.0019 17.9 1.7 0.0031 17.2 0.1 2.3 3 0 0 3 3 3 1 Homeobox domain DUF788 PF05620.9 MSTRG.18812.1_3 - 4.9 6.9 5.6 21 4.9 0.0 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF788) DUF3585 PF12130.6 MSTRG.4471.2_1 - 7.5e-35 119.9 22.8 7.5e-35 119.9 22.8 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3585) CH PF00307.29 MSTRG.4471.2_1 - 5e-22 78.0 0.0 1.2e-21 76.8 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 MSTRG.4471.2_1 - 2.3e-11 43.2 0.0 5.3e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain LIM PF00412.20 MSTRG.4471.2_1 - 1.7e-07 31.2 3.5 4.1e-07 30.0 3.5 1.6 1 0 0 1 1 1 1 LIM domain FAD_binding_3 PF01494.17 MSTRG.4471.2_1 - 5.3e-05 22.5 0.5 8.9e-05 21.8 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.12 MSTRG.4471.2_1 - 0.00036 19.7 0.0 0.00065 18.9 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 MSTRG.4471.2_1 - 0.00064 18.9 0.0 0.0012 18.1 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 MSTRG.4471.2_1 - 0.002 17.7 0.0 0.077 12.5 0.1 2.5 1 1 1 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.12 MSTRG.4471.2_1 - 0.0092 14.6 0.0 0.018 13.6 0.0 1.4 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.4 MSTRG.4471.2_1 - 0.0092 16.1 0.0 0.022 14.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain CH_2 PF06294.9 MSTRG.4471.2_1 - 0.0095 15.9 0.0 0.035 14.1 0.0 2.0 2 0 0 2 2 1 1 CH-like domain in sperm protein Lar_restr_allev PF14354.4 MSTRG.4471.2_1 - 0.017 15.4 1.6 0.047 13.9 1.6 1.7 1 0 0 1 1 1 0 Restriction alleviation protein Lar FAD_binding_2 PF00890.22 MSTRG.4471.2_1 - 0.02 13.8 0.3 0.045 12.7 0.0 1.7 2 0 0 2 2 2 0 FAD binding domain NAD_binding_7 PF13241.4 MSTRG.4471.2_1 - 0.078 13.3 0.0 0.26 11.6 0.0 1.8 1 0 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox PF00070.25 MSTRG.4471.2_1 - 0.12 12.8 0.0 0.42 11.1 0.0 2.0 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase zf-H2C2_2 PF13465.4 MSTRG.23411.1_1 - 8.2e-11 41.7 8.2 2.7e-06 27.4 1.5 5.2 6 0 0 6 6 6 2 Zinc-finger double domain zf-C2H2 PF00096.24 MSTRG.23411.1_1 - 1.8e-06 28.0 21.0 0.00021 21.4 0.9 4.8 5 0 0 5 5 5 3 Zinc finger, C2H2 type FOXP-CC PF16159.3 MSTRG.23411.1_1 - 0.0035 17.8 5.5 1.1 9.7 1.3 2.6 1 1 2 3 3 3 2 FOXP coiled-coil domain zf-C2H2_4 PF13894.4 MSTRG.23411.1_1 - 0.052 14.3 0.8 0.052 14.3 0.8 5.1 5 0 0 5 5 5 0 C2H2-type zinc finger Neur_chan_memb PF02932.14 MSTRG.9722.1_3 - 3.3e-36 125.4 8.1 1.1e-30 107.3 5.0 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 MSTRG.9722.1_3 - 5.7e-14 52.0 0.0 1.1e-13 51.0 0.0 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain G-patch PF01585.21 MSTRG.14016.4_2 - 1.3e-17 63.3 2.9 2.7e-17 62.3 2.9 1.5 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.20 MSTRG.14016.4_2 - 4.2e-15 55.2 0.0 1.5e-06 27.8 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP PF00641.16 MSTRG.14016.4_2 - 2.7e-10 39.2 1.5 6.2e-10 38.1 1.5 1.7 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others G-patch_2 PF12656.5 MSTRG.14016.4_2 - 1.8e-07 31.0 0.6 1.8e-07 31.0 0.6 2.1 2 0 0 2 2 2 1 G-patch domain zf-C2H2_jaz PF12171.6 MSTRG.14016.4_2 - 0.057 13.6 0.1 0.14 12.4 0.1 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.4 MSTRG.14016.4_2 - 0.071 13.9 0.1 0.26 12.1 0.1 2.1 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2HE PF16278.3 MSTRG.14016.4_2 - 0.095 13.0 0.3 3.3 8.1 0.3 3.1 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2 PF00096.24 MSTRG.14016.4_2 - 2.5 8.6 5.9 0.39 11.1 0.2 2.8 2 1 1 3 3 3 0 Zinc finger, C2H2 type p450 PF00067.20 MSTRG.7569.1_1 - 5.8e-105 351.6 0.0 7.1e-105 351.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Oxysterol_BP PF01237.16 MSTRG.23543.1_3 - 6.8e-79 265.2 4.7 2.1e-77 260.3 4.7 2.1 1 1 0 1 1 1 1 Oxysterol-binding protein PH PF00169.27 MSTRG.23543.1_3 - 7.6e-14 52.0 0.5 3.3e-13 49.9 0.0 2.3 2 0 0 2 2 2 1 PH domain PH_8 PF15409.4 MSTRG.23543.1_3 - 2.2e-08 34.1 0.2 5.4e-08 32.9 0.2 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.4 MSTRG.23543.1_3 - 3e-06 27.5 3.2 5.8e-05 23.3 3.2 2.8 1 1 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.4 MSTRG.23543.1_3 - 0.0011 19.1 0.0 0.0023 18.1 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain Nebulin PF00880.16 MSTRG.1479.2_2 - 0 1707.4 587.3 2.6e-10 39.9 2.0 141.4 147 0 0 147 147 147 112 Nebulin repeat Peptidase_M24 PF00557.22 MSTRG.1479.2_2 - 2.9e-14 53.1 3.4 0.28 10.7 0.0 9.5 9 0 0 9 9 9 5 Metallopeptidase family M24 SH3_1 PF00018.26 MSTRG.1479.2_2 - 3.1e-12 45.7 0.0 1.5e-11 43.6 0.0 2.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 MSTRG.1479.2_2 - 3.5e-12 45.9 0.0 7.5e-12 44.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 MSTRG.1479.2_2 - 1e-05 25.0 0.0 8e-05 22.1 0.0 2.6 2 0 0 2 2 2 1 Variant SH3 domain Toprim_2 PF13155.4 MSTRG.1479.2_2 - 0.45 10.9 7.7 69 3.9 0.0 6.1 6 0 0 6 6 6 0 Toprim-like Sugar_tr PF00083.22 MSTRG.26392.1_3 - 4.8e-19 68.4 15.8 4.6e-15 55.3 12.7 2.7 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.14 MSTRG.26392.1_3 - 3.1e-15 55.8 26.7 1.9e-10 40.1 19.5 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily DUF2754 PF10953.6 MSTRG.26392.1_3 - 1.3 9.2 5.6 7.4 6.8 0.7 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2754) ATP11 PF06644.9 MSTRG.8478.1_2 - 1.2e-49 169.5 0.1 1.5e-49 169.1 0.1 1.1 1 0 0 1 1 1 1 ATP11 protein Peptidase_C78 PF07910.11 MSTRG.13418.1_2 - 2.4e-65 219.8 0.0 3.7e-65 219.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family C78 GAGA PF09237.9 MSTRG.13418.1_2 - 0.0029 17.2 3.1 0.36 10.5 0.2 3.4 2 1 1 3 3 3 2 GAGA factor zf-C2H2_4 PF13894.4 MSTRG.13418.1_2 - 0.0031 18.1 15.6 0.11 13.3 0.3 5.4 5 0 0 5 5 5 2 C2H2-type zinc finger zf-Di19 PF05605.10 MSTRG.13418.1_2 - 0.011 15.9 23.5 0.013 15.6 4.4 3.8 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.6 MSTRG.13418.1_2 - 0.077 13.2 4.5 4.7 7.5 0.1 4.2 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.24 MSTRG.13418.1_2 - 0.15 12.4 9.6 0.42 11.0 0.1 4.6 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-met PF12874.5 MSTRG.13418.1_2 - 2.1 8.7 5.6 7.3 7.0 0.2 4.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Sec61_beta PF03911.14 MSTRG.6998.2_1 - 8.5e-19 67.2 0.0 1.5e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 Sec61beta family zf-RanBP PF00641.16 MSTRG.6998.2_3 - 2 7.7 10.3 0.72 9.1 0.4 3.1 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others FAM184 PF15665.3 MSTRG.20122.1_2 - 8.1e-07 28.9 1.0 8.1e-07 28.9 1.0 3.9 2 1 2 4 4 4 2 Family with sequence similarity 184, A and B Reo_sigmaC PF04582.10 MSTRG.20122.1_2 - 0.0047 16.2 5.0 0.038 13.3 1.4 2.2 1 1 1 2 2 2 2 Reovirus sigma C capsid protein Laminin_II PF06009.10 MSTRG.20122.1_2 - 0.012 15.5 4.1 0.012 15.5 4.1 3.8 2 2 2 4 4 4 0 Laminin Domain II GAS PF13851.4 MSTRG.20122.1_2 - 4.1 6.6 58.3 3.6 6.8 28.6 2.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Golgin_A5 PF09787.7 MSTRG.20122.1_2 - 5.8 6.1 54.7 1.2 8.4 28.5 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 Thioredoxin_6 PF13848.4 MSTRG.27480.1_3 - 9.2e-35 120.1 3.4 1.3e-29 103.3 1.0 3.3 3 1 0 3 3 3 3 Thioredoxin-like domain Thioredoxin PF00085.18 MSTRG.27480.1_3 - 3.4e-25 87.9 0.0 7.4e-12 45.0 0.0 3.5 4 0 0 4 4 4 2 Thioredoxin Calsequestrin PF01216.15 MSTRG.27480.1_3 - 2.6e-10 39.7 0.1 3.7e-10 39.3 0.1 1.2 1 0 0 1 1 1 1 Calsequestrin Thioredoxin_7 PF13899.4 MSTRG.27480.1_3 - 0.034 14.2 0.8 0.37 10.9 0.1 2.8 3 0 0 3 3 3 0 Thioredoxin-like PI3Ka PF00613.18 MSTRG.4724.1_2 - 4.3e-49 166.3 2.5 4.7e-49 166.2 2.5 1.0 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) HEAT PF02985.20 MSTRG.4724.1_2 - 0.11 12.6 0.0 0.29 11.4 0.0 1.7 1 0 0 1 1 1 0 HEAT repeat Macoilin PF09726.7 MSTRG.11937.3_1 - 0.0043 15.6 0.2 0.0053 15.3 0.2 1.1 1 0 0 1 1 1 1 Transmembrane protein Spc7 PF08317.9 MSTRG.11937.3_1 - 0.03 13.1 8.7 0.044 12.5 8.7 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein IncA PF04156.12 MSTRG.11937.3_1 - 0.056 13.1 4.3 0.092 12.4 4.3 1.2 1 0 0 1 1 1 0 IncA protein DUF3450 PF11932.6 MSTRG.11937.3_1 - 0.12 11.5 1.1 0.19 10.9 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Seryl_tRNA_N PF02403.20 MSTRG.11937.3_1 - 3 8.0 9.4 6.1 7.0 9.4 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain PH PF00169.27 MSTRG.11937.3_2 - 8.7e-26 90.3 2.0 8.1e-13 48.7 0.1 3.2 3 0 0 3 3 3 2 PH domain PH_11 PF15413.4 MSTRG.11937.3_2 - 6.4e-06 26.4 0.8 0.017 15.4 0.0 3.1 2 1 0 2 2 2 2 Pleckstrin homology domain PH_9 PF15410.4 MSTRG.11937.3_2 - 0.00065 19.9 0.4 6 7.1 0.1 3.9 2 2 0 2 2 2 2 Pleckstrin homology domain Sharpin_PH PF16764.3 MSTRG.11937.3_2 - 0.063 13.0 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Sharpin PH domain Folliculin_C PF16692.3 MSTRG.6880.1_3 - 7.9e-84 280.7 0.0 1.1e-83 280.3 0.0 1.2 1 0 0 1 1 1 1 Folliculin C-terminal domain Folliculin PF11704.6 MSTRG.6880.1_3 - 4.5e-50 169.8 0.0 6.4e-50 169.3 0.0 1.2 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport Collagen PF01391.16 MSTRG.19253.2_3 - 4.3e-17 61.5 97.3 1.5e-07 30.9 47.2 3.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Aminotran_1_2 PF00155.19 MSTRG.4175.1_1 - 2.4e-88 296.6 0.0 2.9e-88 296.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Lebercilin PF15619.4 MSTRG.4321.1_2 - 1.1e-16 60.9 16.3 2.1e-16 60.0 16.3 1.5 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease NTR PF01759.19 MSTRG.4321.1_2 - 0.21 11.3 3.4 1.8 8.3 0.2 2.4 2 0 0 2 2 2 0 UNC-6/NTR/C345C module NPV_P10 PF05531.10 MSTRG.4321.1_2 - 0.29 11.5 4.8 1.6 9.1 3.3 2.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein TPR_MLP1_2 PF07926.10 MSTRG.4321.1_2 - 0.55 10.2 14.0 1 9.3 7.4 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein HPD PF05044.10 MSTRG.9682.1_1 - 6e-82 273.0 1.0 9.3e-82 272.4 1.0 1.3 1 0 0 1 1 1 1 Homeo-prospero domain ERM PF00769.17 MSTRG.9682.1_1 - 0.0028 17.4 3.9 0.0054 16.5 3.9 1.5 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Nop25 PF09805.7 MSTRG.9682.1_1 - 0.033 14.5 5.6 0.073 13.4 5.6 1.5 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) NifQ PF04891.10 MSTRG.9682.1_1 - 0.069 13.4 0.5 0.49 10.6 0.0 2.3 2 0 0 2 2 2 0 NifQ zf-CpG_bind_C PF12269.6 MSTRG.9682.1_1 - 0.65 9.6 5.7 1.1 8.8 5.7 1.3 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain Tmp39 PF10271.7 MSTRG.17498.1_1 - 7.2e-184 611.6 20.1 8.8e-184 611.4 20.1 1.1 1 0 0 1 1 1 1 Putative transmembrane protein zf-C2H2 PF00096.24 MSTRG.3239.1_3 - 1.6e-30 103.7 133.8 0.00041 20.5 0.4 14.2 14 0 0 14 14 14 13 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 MSTRG.3239.1_3 - 2.2e-28 97.3 101.5 9e-09 35.3 0.0 14.4 14 0 0 14 14 14 9 Zinc-finger double domain zf-C2H2_4 PF13894.4 MSTRG.3239.1_3 - 6.5e-25 85.5 128.9 0.0018 18.8 0.6 14.5 14 0 0 14 14 14 13 C2H2-type zinc finger zf-met PF12874.5 MSTRG.3239.1_3 - 2.9e-11 43.2 85.3 0.0085 16.3 2.9 12.5 12 0 0 12 12 12 7 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 MSTRG.3239.1_3 - 7.4e-09 35.6 100.4 0.018 15.2 3.5 13.3 12 1 1 13 13 13 7 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 MSTRG.3239.1_3 - 0.00036 20.3 4.6 0.00036 20.3 4.6 12.0 13 0 0 13 13 13 6 C2H2-type zinc finger GAGA PF09237.9 MSTRG.3239.1_3 - 0.033 13.8 9.7 6 6.6 1.0 4.0 3 0 0 3 3 3 0 GAGA factor BolA PF01722.16 MSTRG.3239.1_3 - 0.12 12.6 0.1 0.12 12.6 0.1 5.6 5 2 1 6 6 6 0 BolA-like protein zf-C2H2_2 PF12756.5 MSTRG.3239.1_3 - 3 8.1 86.9 0.23 11.7 0.9 10.3 4 2 6 10 10 10 0 C2H2 type zinc-finger (2 copies) Pkinase PF00069.23 MSTRG.14667.1_1 - 1.2e-42 146.0 0.0 1.5e-42 145.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 MSTRG.14667.1_1 - 2e-23 82.8 0.0 2.4e-23 82.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 MSTRG.14667.1_1 - 4.1e-12 45.9 0.0 4.7e-12 45.7 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.21 MSTRG.14667.1_1 - 0.0071 16.2 0.1 0.011 15.6 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.12 MSTRG.14667.1_1 - 0.017 14.4 0.2 0.026 13.7 0.2 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Myotub-related PF06602.12 MSTRG.17334.2_2 - 2.9e-15 55.9 0.1 5e-15 55.2 0.1 1.3 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Myotub-related PF06602.12 MSTRG.17334.2_3 - 5.3e-52 176.7 1.0 7e-52 176.3 1.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain 3-PAP PF12578.6 MSTRG.17334.2_3 - 4.9e-41 139.4 0.0 8e-41 138.7 0.0 1.3 1 0 0 1 1 1 1 Myotubularin-associated protein Peptidase_C1 PF00112.21 MSTRG.7456.1_3 - 3.8e-70 236.3 1.2 6.6e-70 235.5 1.2 1.4 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 MSTRG.7456.1_3 - 4e-12 46.2 0.5 8.9e-12 45.1 0.5 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Cystatin PF00031.19 MSTRG.7456.1_3 - 3.1e-11 43.3 0.0 6.1e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 Cystatin domain Peptidase_C1_2 PF03051.13 MSTRG.7456.1_3 - 1.1e-05 24.3 0.5 0.001 17.8 0.0 2.2 2 0 0 2 2 2 2 Peptidase C1-like family Gal-3-0_sulfotr PF06990.9 MSTRG.5633.1_2 - 5.5e-142 473.2 0.1 6.8e-142 472.9 0.1 1.0 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.12 MSTRG.5633.1_2 - 0.097 12.4 0.6 0.85 9.3 0.2 2.1 2 0 0 2 2 2 0 Sulfotransferase family Mito_carr PF00153.25 MSTRG.20765.2_2 - 4.9e-61 202.6 1.0 1.4e-21 76.0 0.1 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein Beach PF02138.16 MSTRG.5192.1_3 - 6.7e-21 74.8 0.5 9.9e-21 74.2 0.5 1.3 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.4 MSTRG.5192.1_3 - 7.1e-17 61.2 0.0 1.3e-16 60.4 0.0 1.4 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Myb_DNA-binding PF00249.29 MSTRG.25001.1_2 - 1.8e-11 43.9 0.3 3.9e-11 42.8 0.3 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.15 MSTRG.25001.1_2 - 1.2e-06 28.0 6.1 3.1e-06 26.8 6.1 1.7 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-bind_6 PF13921.4 MSTRG.25001.1_2 - 3.6e-05 23.8 0.2 0.0001 22.4 0.2 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain CO_dh PF02552.14 MSTRG.18030.1_3 - 0.0057 16.3 0.0 0.018 14.7 0.0 1.8 1 0 0 1 1 1 1 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit Serum_albumin PF00273.18 MSTRG.18030.1_3 - 0.083 12.5 2.8 0.62 9.7 0.2 2.8 2 0 0 2 2 2 0 Serum albumin family DUF1289 PF06945.11 MSTRG.25429.2_2 - 0.074 12.7 0.3 0.16 11.7 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1289) Hox9_act PF04617.11 MSTRG.25429.2_3 - 2e-33 116.6 1.1 3e-33 116.0 1.1 1.2 1 0 0 1 1 1 1 Hox9 activation region Homeobox PF00046.27 MSTRG.25429.2_3 - 2.4e-20 72.0 4.4 3.8e-20 71.3 4.4 1.3 1 0 0 1 1 1 1 Homeobox domain HTH_23 PF13384.4 MSTRG.25429.2_3 - 0.048 13.3 0.1 0.087 12.5 0.1 1.3 1 0 0 1 1 1 0 Homeodomain-like domain RRM_1 PF00076.20 MSTRG.18254.1_3 - 1.3e-26 92.1 0.1 8.4e-15 54.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 MSTRG.18254.1_3 - 2.2e-06 27.6 0.2 0.1 12.6 0.0 2.9 3 0 0 3 3 3 2 RNA recognition motif Nup35_RRM_2 PF14605.4 MSTRG.18254.1_3 - 0.051 13.4 0.1 3 7.8 0.0 2.5 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.9 MSTRG.18254.1_3 - 0.18 11.8 0.0 1.8 8.5 0.0 2.2 2 0 0 2 2 2 0 RNA binding motif CD36 PF01130.19 MSTRG.19646.1_3 - 9e-114 380.4 0.3 1e-113 380.2 0.3 1.0 1 0 0 1 1 1 1 CD36 family Methyltransf_3 PF01596.15 MSTRG.17855.1_3 - 1.7e-10 40.3 0.0 2.7e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.4 MSTRG.17855.1_3 - 1.9e-07 32.0 0.0 3.8e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.17 MSTRG.17855.1_3 - 0.073 12.7 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PTB PF08416.11 MSTRG.13985.1_2 - 1.6e-30 105.8 0.3 2.7e-30 105.1 0.3 1.3 1 0 0 1 1 1 1 Phosphotyrosine-binding domain SH3_1 PF00018.26 MSTRG.13985.1_2 - 8.2e-09 34.8 0.0 1.4e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 MSTRG.13985.1_2 - 3e-08 33.1 0.0 6.5e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 MSTRG.13985.1_2 - 4.2e-06 26.4 0.0 8.7e-06 25.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 MSTRG.13985.1_2 - 9.4e-05 22.5 0.1 0.00018 21.5 0.1 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain SAM_PNT PF02198.14 MSTRG.13985.1_2 - 0.05 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain hSH3 PF14603.4 MSTRG.13985.1_2 - 0.061 13.7 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 Helically-extended SH3 domain Reo_sigmaC PF04582.10 MSTRG.5740.2_1 - 0.0078 15.5 3.4 0.011 15.0 3.4 1.2 1 0 0 1 1 1 1 Reovirus sigma C capsid protein DUF1664 PF07889.10 MSTRG.5740.2_1 - 0.015 15.1 4.4 0.015 15.1 4.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) GIT_CC PF16559.3 MSTRG.5740.2_1 - 0.13 12.1 5.6 0.5 10.3 5.6 2.0 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Spc7 PF08317.9 MSTRG.5740.2_1 - 0.16 10.7 20.5 0.26 10.0 19.6 1.7 1 1 1 2 2 2 0 Spc7 kinetochore protein COG2 PF06148.9 MSTRG.5740.2_1 - 0.17 11.8 7.6 0.087 12.8 4.4 2.0 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Lge1 PF11488.6 MSTRG.5740.2_1 - 0.28 11.6 2.3 0.75 10.3 2.3 1.8 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 DUF948 PF06103.9 MSTRG.5740.2_1 - 0.34 11.0 3.1 0.96 9.6 3.1 1.8 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.10 MSTRG.5740.2_1 - 0.56 10.1 10.4 0.055 13.4 3.8 2.4 1 1 0 2 2 2 0 Laminin Domain II DUF5082 PF16888.3 MSTRG.5740.2_1 - 0.59 10.4 15.0 0.24 11.6 11.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) DUF2730 PF10805.6 MSTRG.5740.2_1 - 0.85 9.6 4.6 1.7 8.6 3.7 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) IncA PF04156.12 MSTRG.5740.2_1 - 1.1 8.9 18.4 6.7 6.3 18.3 2.2 1 1 0 1 1 1 0 IncA protein DUF1640 PF07798.9 MSTRG.5740.2_1 - 1.6 8.6 13.4 18 5.2 13.8 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1640) Sec20 PF03908.11 MSTRG.5740.2_1 - 1.8 8.4 5.6 1.4 8.8 2.6 2.4 2 0 0 2 2 2 0 Sec20 SlyX PF04102.10 MSTRG.5740.2_1 - 4.3 7.9 13.6 0.43 11.1 3.0 3.5 2 1 1 3 3 3 0 SlyX Cnn_1N PF07989.9 MSTRG.5740.2_1 - 4.5 7.3 15.8 0.5 10.4 4.3 3.8 1 1 3 4 4 4 0 Centrosomin N-terminal motif 1 V_ATPase_I PF01496.17 MSTRG.5740.2_1 - 6 4.5 10.2 8.6 4.0 10.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FliJ PF02050.14 MSTRG.5740.2_1 - 9.8 6.3 19.9 0.053 13.6 8.6 2.6 3 0 0 3 3 3 0 Flagellar FliJ protein Pex2_Pex12 PF04757.12 MSTRG.20488.1_1 - 1.1e-38 133.0 1.5 1.4e-38 132.6 1.5 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.4 MSTRG.20488.1_1 - 6.5e-09 35.4 10.6 6.5e-09 35.4 10.6 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 MSTRG.20488.1_1 - 6e-08 32.7 15.7 6e-08 32.7 15.7 3.1 2 0 0 2 2 2 1 Ring finger domain Prok-RING_4 PF14447.4 MSTRG.20488.1_1 - 8.2e-08 31.9 11.5 2.4e-07 30.4 11.5 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.4 MSTRG.20488.1_1 - 6e-07 29.1 13.2 2.1e-06 27.3 13.2 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 MSTRG.20488.1_1 - 1e-06 28.3 14.1 1e-06 28.3 14.1 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 MSTRG.20488.1_1 - 3e-05 24.1 11.1 0.00012 22.1 11.1 2.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.4 MSTRG.20488.1_1 - 5.8e-05 22.8 11.9 0.0003 20.6 11.9 2.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 MSTRG.20488.1_1 - 0.00013 21.8 11.1 0.00082 19.2 8.8 3.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 MSTRG.20488.1_1 - 0.013 15.5 11.4 0.013 15.5 11.4 2.7 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING AAA_13 PF13166.4 MSTRG.22790.4_1 - 0.00033 19.3 4.2 0.00038 19.1 4.2 1.1 1 0 0 1 1 1 1 AAA domain IncA PF04156.12 MSTRG.22790.4_1 - 0.0014 18.3 8.3 0.0019 17.9 8.3 1.2 1 0 0 1 1 1 1 IncA protein Reo_sigmaC PF04582.10 MSTRG.22790.4_1 - 0.0047 16.2 0.1 0.0052 16.1 0.1 1.2 1 0 0 1 1 1 1 Reovirus sigma C capsid protein GIT1_C PF12205.6 MSTRG.22790.4_1 - 0.0049 16.8 3.5 0.12 12.4 2.0 2.8 2 1 1 3 3 3 1 G protein-coupled receptor kinase-interacting protein 1 C term PMEI PF04043.13 MSTRG.22790.4_1 - 0.006 16.9 0.7 0.011 16.0 0.7 1.4 1 0 0 1 1 1 1 Plant invertase/pectin methylesterase inhibitor PI3K_P85_iSH2 PF16454.3 MSTRG.22790.4_1 - 0.014 14.8 13.6 0.071 12.5 10.5 2.8 2 1 1 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Uteroglobin PF01099.15 MSTRG.22790.4_1 - 0.017 15.2 1.9 1.5 8.9 0.1 2.5 2 0 0 2 2 2 0 Uteroglobin family Exonuc_VII_L PF02601.13 MSTRG.22790.4_1 - 0.018 14.5 6.3 0.02 14.3 6.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Prefoldin_2 PF01920.18 MSTRG.22790.4_1 - 0.024 14.5 6.2 0.066 13.1 6.2 1.9 1 1 0 1 1 1 0 Prefoldin subunit DUF948 PF06103.9 MSTRG.22790.4_1 - 0.025 14.7 6.3 1.3 9.2 0.3 3.4 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) HAMP PF00672.23 MSTRG.22790.4_1 - 0.028 14.5 0.9 8.4 6.6 0.1 3.2 3 1 0 3 3 2 0 HAMP domain Baculo_PEP_C PF04513.10 MSTRG.22790.4_1 - 0.041 13.8 1.0 0.13 12.2 0.5 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus NRN1 PF15056.4 MSTRG.22790.4_1 - 0.042 13.8 1.4 0.092 12.7 0.2 2.1 3 0 0 3 3 2 0 Neuritin protein family TolA_bind_tri PF16331.3 MSTRG.22790.4_1 - 0.083 12.8 12.6 7.1 6.7 8.7 3.6 1 1 1 2 2 2 0 TolA binding protein trimerisation LXG PF04740.10 MSTRG.22790.4_1 - 0.11 12.1 10.1 0.17 11.5 5.5 2.7 1 1 1 2 2 2 0 LXG domain of WXG superfamily DUF4407 PF14362.4 MSTRG.22790.4_1 - 0.11 11.7 4.2 0.16 11.2 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ApoLp-III PF07464.9 MSTRG.22790.4_1 - 0.12 12.3 5.3 0.58 10.1 2.6 2.6 2 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) YvrJ PF12841.5 MSTRG.22790.4_1 - 0.13 11.7 0.8 7.9 6.0 0.0 3.2 3 0 0 3 3 3 0 YvrJ protein family Prominin PF05478.9 MSTRG.22790.4_1 - 0.14 10.0 6.2 0.12 10.1 4.8 1.4 1 1 0 1 1 1 0 Prominin DUF1690 PF07956.9 MSTRG.22790.4_1 - 0.15 12.4 9.8 0.2 11.9 7.5 2.2 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) Syntaxin-6_N PF09177.9 MSTRG.22790.4_1 - 0.15 12.5 6.4 1.3 9.5 5.1 2.7 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Y1_Tnp PF01797.14 MSTRG.22790.4_1 - 0.15 12.0 2.6 0.29 11.1 0.8 2.2 1 1 0 2 2 2 0 Transposase IS200 like C_Hendra PF16821.3 MSTRG.22790.4_1 - 0.17 11.6 10.4 0.84 9.4 2.9 2.2 1 1 1 2 2 2 0 C protein from hendra and measles viruses Spore_III_AB PF09548.8 MSTRG.22790.4_1 - 0.23 11.4 5.5 0.76 9.7 5.5 1.8 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) T3SSipB PF16535.3 MSTRG.22790.4_1 - 0.27 11.6 7.9 2 8.7 0.2 2.5 2 1 1 3 3 2 0 Type III cell invasion protein SipB OmpH PF03938.12 MSTRG.22790.4_1 - 0.3 11.0 9.2 0.21 11.5 6.7 1.9 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Phasin PF05597.9 MSTRG.22790.4_1 - 0.34 10.8 5.0 0.52 10.2 0.3 2.4 2 1 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF1664 PF07889.10 MSTRG.22790.4_1 - 0.36 10.7 9.1 0.6 10.0 3.7 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF3373 PF11853.6 MSTRG.22790.4_1 - 0.38 9.3 9.1 14 4.1 9.1 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3373) TMPIT PF07851.11 MSTRG.22790.4_1 - 0.52 9.4 6.7 0.79 8.8 6.7 1.4 1 0 0 1 1 1 0 TMPIT-like protein DUF342 PF03961.11 MSTRG.22790.4_1 - 0.55 8.6 8.1 1.1 7.6 8.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF342) DUF148 PF02520.15 MSTRG.22790.4_1 - 0.58 10.2 7.3 0.23 11.4 4.3 1.8 2 1 0 2 2 2 0 Domain of unknown function DUF148 LUC7 PF03194.13 MSTRG.22790.4_1 - 0.58 9.6 13.3 2.1 7.8 12.3 2.3 1 1 0 1 1 1 0 LUC7 N_terminus Mod_r PF07200.11 MSTRG.22790.4_1 - 0.65 10.0 13.3 0.91 9.5 2.0 2.4 2 1 1 3 3 2 0 Modifier of rudimentary (Mod(r)) protein FUSC PF04632.10 MSTRG.22790.4_1 - 0.71 8.2 5.5 0.89 7.9 5.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF972 PF06156.11 MSTRG.22790.4_1 - 0.71 10.4 11.8 1.1 9.8 4.5 2.8 2 1 1 3 3 2 0 Protein of unknown function (DUF972) PhoU PF01895.17 MSTRG.22790.4_1 - 0.88 9.9 6.9 0.7 10.3 3.4 2.4 1 1 1 2 2 2 0 PhoU domain Zwint PF15556.4 MSTRG.22790.4_1 - 0.88 8.9 10.1 1.4 8.2 2.6 2.2 1 1 1 2 2 2 0 ZW10 interactor DUF4200 PF13863.4 MSTRG.22790.4_1 - 0.98 9.7 13.6 2.4 8.4 13.6 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) AATF-Che1 PF13339.4 MSTRG.22790.4_1 - 1.8 9.1 8.0 5.5 7.5 8.0 2.0 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor Ntox16 PF15523.4 MSTRG.22790.4_1 - 2.3 8.4 6.2 0.52 10.4 2.5 1.9 2 1 0 2 2 1 0 Novel toxin 16 GrpE PF01025.17 MSTRG.22790.4_1 - 3.1 7.3 10.0 13 5.3 10.0 2.2 1 1 0 1 1 1 0 GrpE DUF4446 PF14584.4 MSTRG.22790.4_1 - 3.2 7.6 11.2 1.2 9.0 1.3 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF4446) DivIVA PF05103.11 MSTRG.22790.4_1 - 3.5 7.6 12.6 0.6 10.1 8.6 1.8 2 1 0 2 2 2 0 DivIVA protein DUF2937 PF11157.6 MSTRG.22790.4_1 - 3.7 7.1 7.4 4.7 6.7 4.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2937) DUF1635 PF07795.9 MSTRG.22790.4_1 - 4.9 6.9 9.3 11 5.7 7.3 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1635) TBCA PF02970.14 MSTRG.22790.4_1 - 5.3 7.3 11.3 1.5 9.1 7.0 2.3 2 1 0 2 2 1 0 Tubulin binding cofactor A DUF1515 PF07439.9 MSTRG.22790.4_1 - 9 6.2 7.9 42 4.0 7.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) Snapin_Pallidin PF14712.4 MSTRG.22790.4_1 - 10 6.5 11.9 84 3.6 9.8 2.9 2 1 1 3 3 2 0 Snapin/Pallidin CAP_N PF01213.17 MSTRG.15377.2_3 - 4.7e-106 354.7 0.2 3.9e-105 351.7 0.0 2.2 2 0 0 2 2 2 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.9 MSTRG.15377.2_3 - 3.2e-64 215.1 3.1 4.4e-64 214.7 3.1 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.10 MSTRG.15377.2_3 - 6.9e-06 25.7 4.5 1.5e-05 24.6 4.5 1.5 1 0 0 1 1 1 1 Tubulin binding cofactor C Acetyltransf_13 PF13880.4 MSTRG.15070.1_1 - 6.2e-30 102.9 0.0 1.2e-29 102.0 0.0 1.5 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.4 MSTRG.15070.1_1 - 8.9e-16 57.3 0.5 1.7e-15 56.4 0.5 1.4 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO TerB_C PF15615.4 MSTRG.15070.1_3 - 2.1 8.5 5.2 0.18 11.9 0.7 1.6 2 0 0 2 2 2 0 TerB-C domain Ran_BP1 PF00638.16 MSTRG.14831.2_1 - 2e-205 670.5 19.2 1.5e-53 180.1 1.3 4.5 4 0 0 4 4 4 4 RanBP1 domain IR1-M PF12185.6 MSTRG.14831.2_1 - 2.2e-50 168.3 8.7 2.7e-26 91.1 4.9 3.0 2 0 0 2 2 2 2 Nup358/RanBP2 E3 ligase domain Pro_isomerase PF00160.19 MSTRG.14831.2_1 - 9.8e-41 139.5 0.1 2.5e-40 138.2 0.1 1.7 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-RanBP PF00641.16 MSTRG.14831.2_1 - 2e-17 62.1 49.1 1.7e-08 33.5 5.4 4.1 4 0 0 4 4 4 3 Zn-finger in Ran binding protein and others WH1 PF00568.21 MSTRG.14831.2_1 - 2.7e-14 52.9 3.4 0.023 14.5 0.0 4.6 4 0 0 4 4 4 4 WH1 domain TPR_20 PF14561.4 MSTRG.14831.2_1 - 8.8 6.6 7.3 1.3 9.2 0.1 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Enolase_C PF00113.20 MSTRG.3205.1_1 - 1.9e-157 523.0 0.0 2.4e-157 522.6 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.14 MSTRG.3205.1_1 - 2.7e-61 205.4 0.1 4.4e-61 204.7 0.1 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.4 MSTRG.3205.1_1 - 3.5e-07 30.0 0.0 5.7e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.9 MSTRG.3205.1_1 - 0.0025 16.9 0.1 0.0049 15.9 0.1 1.4 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus TMP-TENI PF02581.15 MSTRG.3205.1_1 - 0.024 13.8 0.0 0.041 13.1 0.0 1.3 1 0 0 1 1 1 0 Thiamine monophosphate synthase/TENI FXMRP1_C_core PF12235.6 MSTRG.1745.3_2 - 5.7e-42 143.5 19.2 5.7e-42 143.5 19.2 2.8 1 1 1 2 2 2 1 Fragile X-related 1 protein core C terminal FXR_C1 PF16096.3 MSTRG.1745.3_2 - 1.7e-26 92.1 13.2 1.7e-26 92.1 13.2 2.4 2 1 0 2 2 2 1 Fragile X-related 1 protein C-terminal region 2 KH_1 PF00013.27 MSTRG.1745.3_2 - 3.5e-18 65.0 1.0 7.8e-10 38.3 0.7 2.3 2 0 0 2 2 2 2 KH domain KH_2 PF07650.15 MSTRG.1745.3_2 - 0.0019 17.8 0.3 0.99 9.1 0.0 2.4 2 0 0 2 2 2 2 KH domain KH_4 PF13083.4 MSTRG.1745.3_2 - 0.023 14.5 0.3 2.2 8.1 0.3 2.7 2 1 0 2 2 2 0 KH domain Glypican PF01153.17 MSTRG.24418.1_2 - 5.9e-106 355.4 0.0 1e-97 328.2 0.0 2.1 2 0 0 2 2 2 2 Glypican Pribosyltran_N PF13793.4 MSTRG.7510.2_1 - 5.1e-46 155.2 0.0 1e-45 154.3 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.4 MSTRG.7510.2_1 - 3.6e-43 147.7 2.3 8e-37 127.0 0.9 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.25 MSTRG.7510.2_1 - 5.8e-12 45.3 0.4 1.5e-11 44.0 0.2 1.7 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.4 MSTRG.7510.2_1 - 0.0033 16.8 0.1 0.0051 16.1 0.1 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase 2-Hacid_dh_C PF02826.17 MSTRG.26505.3_1 - 1.4e-54 184.0 0.0 2e-54 183.5 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.28 MSTRG.26505.3_1 - 2.4e-28 98.3 0.0 3.1e-28 98.0 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.13 MSTRG.26505.3_1 - 0.0026 17.8 0.0 0.0049 16.9 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase PH PF00169.27 MSTRG.23827.1_2 - 6.7e-10 39.3 0.0 1.4e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 MSTRG.23827.1_2 - 0.00011 22.4 0.0 0.00021 21.5 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.4 MSTRG.23827.1_2 - 0.07 13.3 0.1 1.6 9.0 0.1 2.3 1 1 0 1 1 1 0 Pleckstrin homology domain IQ_SEC7_PH PF16453.3 MSTRG.24752.3_3 - 1.1e-66 222.9 0.1 3.8e-66 221.1 0.1 1.9 1 0 0 1 1 1 1 PH domain Sec7 PF01369.18 MSTRG.24752.3_3 - 1.8e-58 197.2 0.0 3.5e-58 196.2 0.0 1.5 1 0 0 1 1 1 1 Sec7 domain SQS_PSY PF00494.17 MSTRG.8325.2_1 - 1.8e-42 145.5 0.0 2.4e-42 145.1 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase HAUS4 PF14735.4 MSTRG.8325.2_1 - 0.036 13.6 0.0 0.058 13.0 0.0 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 Octopine_DH PF02317.15 MSTRG.8325.2_1 - 0.13 12.2 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain Dsh_C PF12316.6 MSTRG.14267.2_2 - 0.032 14.5 2.9 0.047 14.0 2.9 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal TFIID_20kDa PF03847.11 MSTRG.14267.2_3 - 9.8e-36 122.0 2.8 1.4e-35 121.4 2.8 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.21 MSTRG.14267.2_3 - 0.00025 21.1 0.1 0.00043 20.4 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.13 MSTRG.14267.2_3 - 0.00033 20.6 0.0 0.00049 20.0 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Histone PF00125.22 MSTRG.14267.2_3 - 0.0017 18.6 0.1 0.0032 17.7 0.1 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF4 PF05236.12 MSTRG.14267.2_3 - 0.0097 15.6 0.0 0.012 15.3 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family CENP-T_C PF15511.4 MSTRG.14267.2_3 - 0.079 12.9 0.1 0.14 12.2 0.1 1.3 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold Hexapep PF00132.22 MSTRG.4022.1_1 - 1.3e-12 46.8 21.5 1.7e-05 24.2 2.8 4.5 3 1 2 5 5 5 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.4 MSTRG.4022.1_1 - 0.002 17.7 8.6 0.015 14.9 0.6 3.6 3 1 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.3 MSTRG.4022.1_1 - 0.071 11.1 1.4 0.097 10.6 1.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) Fucokinase PF07959.10 MSTRG.4022.1_1 - 0.44 9.4 5.1 6.2 5.6 5.1 2.0 1 1 0 1 1 1 0 L-fucokinase Synuclein PF01387.15 MSTRG.7330.1_3 - 3.2e-36 124.3 15.7 3.9e-22 78.8 9.2 2.2 1 1 1 2 2 2 2 Synuclein Trypan_PARP PF05887.9 MSTRG.7330.1_3 - 0.9 9.4 9.8 1.2 9.1 9.3 1.4 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) SH3BGR PF04908.13 MSTRG.4319.1_1 - 2.9e-42 142.7 0.0 4.9e-42 142.0 0.0 1.4 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.22 MSTRG.4319.1_1 - 0.011 15.8 0.0 0.029 14.4 0.0 1.7 1 0 0 1 1 1 0 Glutaredoxin Sugar_tr PF00083.22 MSTRG.6923.1_1 - 3.1e-148 494.3 21.3 4.1e-148 493.9 21.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 MSTRG.6923.1_1 - 7.3e-18 64.5 36.2 1.3e-17 63.6 30.4 2.3 1 1 0 2 2 2 2 Major Facilitator Superfamily Phage_holin_3_2 PF04550.10 MSTRG.6923.1_1 - 2.4 8.5 6.0 6.7 7.0 6.0 1.7 1 0 0 1 1 1 0 Phage holin family 2 Ammonium_transp PF00909.19 MSTRG.22061.1_1 - 2.3e-71 240.5 22.9 2.6e-71 240.3 22.9 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF4293 PF14126.4 MSTRG.22061.1_1 - 0.1 12.7 1.2 0.29 11.2 0.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4293) DUF3042 PF11240.6 MSTRG.22061.1_1 - 3.5 7.6 4.2 47 4.0 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3042) # # Program: hmmscan # Version: 3.1b2 (February 2015) # Pipeline mode: SCAN # Query file: /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/realdata/seahorse/wd/merged_no_G.p.fa # Target file: /home/yduan/database/Pfam/Pfam-A.hmm # Option settings: hmmscan -o /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/realdata/seahorse/hmmscan.outm --tblout /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/realdata/seahorse/hmmscan.t.out /home/yduan/database/Pfam/Pfam-A.hmm /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/realdata/seahorse/wd/merged_no_G.p.fa # Current dir: /home/yduan/work_file/lncRNAdb/methods_assement # Date: Wed Aug 22 22:08:27 2018 # [ok]