# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- CDP-OH_P_transf PF01066.19 001283196.1_29525001_2 - 2.3e-17 63.4 0.2 2.3e-17 63.4 0.2 3.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Guanylate_kin PF00625.19 001194912.1_29629001_2 - 5.3e-65 218.4 0.6 7.6e-65 217.9 0.6 1.2 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.22 001194912.1_29629001_2 - 5.7e-47 157.8 10.1 1.9e-20 72.8 0.3 4.1 3 1 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_assoc PF10600.7 001194912.1_29629001_2 - 1.6e-27 96.0 3.2 3.9e-27 94.8 3.2 1.7 1 0 0 1 1 1 1 PDZ-associated domain of NMDA receptors PDZ_2 PF13180.4 001194912.1_29629001_2 - 1.1e-09 38.3 0.3 0.00013 22.1 0.0 2.7 3 0 0 3 3 3 2 PDZ domain SH3_1 PF00018.26 001194912.1_29629001_2 - 3.2e-08 32.9 0.0 1.3e-07 31.0 0.0 2.1 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 001194912.1_29629001_2 - 2.8e-07 30.0 0.0 7.1e-07 28.7 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 001194912.1_29629001_2 - 0.0031 17.2 0.2 0.027 14.2 0.0 2.4 2 0 0 2 2 2 1 Variant SH3 domain Urm1 PF09138.9 001285155.1_29523001_2 - 7e-26 90.3 0.0 1e-25 89.8 0.0 1.2 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) Urm1 PF09138.9 001285155.1_29523001_3 - 8.2e-05 22.8 0.0 0.00012 22.2 0.0 1.1 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) zf-C2H2_2 PF12756.5 001284018.1_29523001_1 - 0.0045 17.2 0.2 0.0091 16.2 0.2 1.4 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) AKAP95 PF04988.10 001284018.1_29523001_1 - 0.023 14.8 0.8 0.037 14.1 0.8 1.3 1 0 0 1 1 1 0 A-kinase anchoring protein 95 (AKAP95) DUF1241 PF06840.9 001283458.1_29524001_2 - 2.3e-62 209.0 3.4 3.2e-62 208.5 3.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Syntaxin_2 PF14523.4 001283458.1_29524001_2 - 0.58 10.4 4.6 1.2 9.4 4.6 1.5 1 1 0 1 1 1 0 Syntaxin-like protein V-set PF07686.15 001280245.1_39725001_2 - 2.1e-33 114.6 0.0 2.5e-19 69.3 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.23 001280245.1_39725001_2 - 5.2e-08 32.8 0.0 0.004 17.2 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001280245.1_39725001_2 - 1.2e-06 28.9 0.0 0.009 16.5 0.0 3.0 2 2 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001280245.1_39725001_2 - 1.7e-05 24.7 0.0 0.29 11.1 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 001280245.1_39725001_2 - 5.3e-05 23.3 0.0 0.046 13.9 0.0 2.9 2 0 0 2 2 2 2 Immunoglobulin domain DUF347 PF03988.10 001280245.1_39725001_2 - 0.03 14.4 0.3 0.071 13.2 0.3 1.6 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) Izumo-Ig PF16706.3 001280245.1_39725001_2 - 0.065 13.2 0.0 10 6.1 0.0 2.4 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.6 001280245.1_39725001_2 - 0.083 13.0 0.0 2 8.5 0.0 2.3 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 DUF4787 PF16029.3 001280245.1_39725001_3 - 0.03 14.3 0.0 0.03 14.3 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4787) Sulfotransfer_1 PF00685.25 001193687.1_29627001_1 - 9e-34 117.0 0.1 1.3e-33 116.5 0.1 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 001193687.1_29627001_1 - 6.9e-09 36.3 0.0 7.7e-05 23.0 0.0 2.2 1 1 1 2 2 2 2 Sulfotransferase family Ribosomal_S24e PF01282.17 001261027.2_29622001_3 - 8.4e-46 153.7 0.5 1.4e-45 153.0 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein S24e Ribosomal_L1 PF00687.19 001329199.1_45724001_1 - 2.6e-53 180.7 1.6 2.6e-53 180.7 1.6 1.7 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family LRRC37AB_C PF14914.4 001302407.1_39724001_2 - 7.6e-66 220.4 6.5 7.6e-66 220.4 6.5 2.4 2 0 0 2 2 2 1 LRRC37A/B like protein 1 C-terminal domain LRRC37 PF15779.3 001302407.1_39724001_2 - 8.5e-32 109.3 57.0 8.8e-16 58.0 23.8 5.5 4 1 2 6 6 6 4 Leucine-rich repeat-containing protein 37 family LRR_8 PF13855.4 001302407.1_39724001_2 - 2e-20 72.2 3.3 3.3e-14 52.2 0.5 3.8 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.5 001302407.1_39724001_2 - 5.2e-08 32.9 12.7 0.00061 20.0 0.7 3.8 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001302407.1_39724001_2 - 0.0017 18.2 0.1 0.0041 16.9 0.1 1.7 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001302407.1_39724001_2 - 0.0019 17.6 0.1 0.0069 15.8 0.1 1.9 1 1 0 1 1 1 1 Leucine-rich repeat LRR_1 PF00560.31 001302407.1_39724001_2 - 0.017 15.3 6.0 24 5.8 0.0 5.2 5 0 0 5 5 5 0 Leucine Rich Repeat DUF912 PF06024.10 001302407.1_39724001_2 - 0.018 15.2 1.0 0.051 13.7 1.0 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Seryl_tRNA_N PF02403.20 001302407.1_39724001_2 - 0.023 14.8 1.4 0.05 13.7 1.4 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Sarcoglycan_2 PF05510.11 001302407.1_39724001_2 - 0.038 12.6 0.2 0.038 12.6 0.2 1.5 2 0 0 2 2 2 0 Sarcoglycan alpha/epsilon TMEM154 PF15102.4 001302407.1_39724001_2 - 0.043 13.6 0.3 0.043 13.6 0.3 2.9 2 1 2 4 4 4 0 TMEM154 protein family Synaptobrevin PF00957.19 001302407.1_39724001_2 - 0.061 13.0 0.1 0.12 12.1 0.1 1.5 1 0 0 1 1 1 0 Synaptobrevin LRR_6 PF13516.4 001302407.1_39724001_2 - 0.49 10.5 6.6 0.89 9.6 0.0 3.9 5 0 0 5 5 5 0 Leucine Rich repeat Vps16_C PF04840.10 001260519.2_29625001_2 - 6.3e-12 45.0 3.1 5.8e-06 25.4 0.4 2.2 2 0 0 2 2 2 2 Vps16, C-terminal region DUF3381 PF11861.6 001260519.2_29625001_2 - 0.088 12.5 0.3 0.2 11.4 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) CEP209_CC5 PF16574.3 001260519.2_29625001_2 - 0.14 12.2 1.3 0.73 9.9 0.1 2.2 2 0 0 2 2 2 0 Coiled-coil region of centrosome protein CE290 Lectin_leg-like PF03388.11 001284798.1_29525001_1 - 4.4e-81 271.5 0.0 8.3e-81 270.6 0.0 1.4 1 1 0 1 1 1 1 Legume-like lectin family PMP1_2 PF08114.9 001284798.1_29525001_1 - 0.033 13.8 0.3 0.089 12.4 0.3 1.8 1 0 0 1 1 1 0 ATPase proteolipid family DUF2042 PF09743.7 001266325.2_29626001_1 - 4.5e-114 380.5 0.7 4.5e-114 380.5 0.7 1.9 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2042) IL31 PF15209.4 001266325.2_29626001_1 - 0.022 14.4 1.4 0.047 13.3 0.1 2.2 2 0 0 2 2 2 0 Interleukin 31 Tn7_Tnp_TnsA_C PF08721.9 001266325.2_29626001_1 - 0.1 13.1 4.9 1 9.9 0.0 4.3 4 1 0 4 4 4 0 TnsA endonuclease C terminal CBFD_NFYB_HMF PF00808.21 001266325.2_29626001_1 - 0.25 11.5 5.4 0.58 10.4 0.2 3.8 5 0 0 5 5 5 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Proteasome PF00227.24 001285064.1_29524001_2 - 1.5e-53 181.0 0.2 2e-53 180.6 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.7 001285064.1_29524001_2 - 1e-14 53.7 0.1 1.8e-14 52.9 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature PMM PF03332.11 001285089.1_29523001_2 - 6.8e-112 372.5 0.1 8.2e-112 372.2 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.10 001285089.1_29523001_2 - 8.2e-07 28.9 0.0 3.4e-06 26.8 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase SPC25 PF06703.9 001191601.1_45726001_3 - 5.8e-44 149.6 0.2 8.4e-44 149.1 0.2 1.2 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) Aa_trans PF01490.16 001283600.1_29525001_3 - 9e-75 251.8 26.6 1.1e-74 251.5 26.6 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein SLD3 PF08639.8 001283600.1_29525001_3 - 0.23 10.1 0.4 0.33 9.5 0.4 1.1 1 0 0 1 1 1 0 DNA replication regulator SLD3 WD40 PF00400.30 001279914.1_39726001_3 - 9.6e-11 41.9 12.0 0.35 11.7 0.0 7.6 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001279914.1_39726001_3 - 1.1e-09 38.3 2.9 0.26 11.5 0.0 6.2 5 1 2 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.12 001279914.1_39726001_3 - 0.00033 19.7 1.3 0.0049 15.8 1.9 2.4 2 0 0 2 2 2 1 Coatomer WD associated region Thiolase_N PF00108.21 001319345.1_29524001_2 - 2e-87 292.7 1.0 2.7e-87 292.3 1.0 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.16 001319345.1_29524001_2 - 8e-49 164.2 0.1 1.7e-48 163.2 0.1 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III_C PF08541.8 001319345.1_29524001_2 - 0.00014 21.9 0.0 0.00056 19.9 0.0 2.0 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ketoacyl-synt PF00109.24 001319345.1_29524001_2 - 0.0098 15.4 1.2 0.07 12.6 0.4 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.8 001319345.1_29524001_2 - 0.021 14.5 0.6 2.6 7.8 0.1 2.7 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ADH_zinc_N PF00107.24 001280091.1_39726001_1 - 6.6e-20 71.2 0.1 1.3e-19 70.3 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.4 001280091.1_39726001_1 - 1.8e-19 71.0 0.0 3.3e-19 70.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 001280091.1_39726001_1 - 3.5e-07 30.0 0.0 9e-07 28.6 0.0 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Abhydrolase_1 PF00561.18 001285225.1_29523001_1 - 4.3e-25 88.7 0.1 1.7e-24 86.7 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001285225.1_29523001_1 - 2.1e-18 67.6 0.0 3.5e-18 66.9 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 001285225.1_29523001_1 - 3.5e-16 59.0 0.0 9.7e-16 57.6 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.12 001285225.1_29523001_1 - 2.7e-06 26.2 0.1 8e-06 24.6 0.1 1.6 1 1 0 1 1 1 1 Ndr family BAAT_C PF08840.9 001285225.1_29523001_1 - 0.0018 18.1 0.1 0.01 15.6 0.0 2.0 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.11 001285225.1_29523001_1 - 0.0027 17.3 0.1 0.29 10.6 0.0 2.5 1 1 1 2 2 2 1 Serine hydrolase (FSH1) DUF1057 PF06342.10 001285225.1_29523001_1 - 0.0034 16.3 0.0 0.0051 15.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) DLH PF01738.16 001285225.1_29523001_1 - 0.0057 16.1 0.0 0.17 11.3 0.0 2.2 2 0 0 2 2 2 1 Dienelactone hydrolase family Thioesterase PF00975.18 001285225.1_29523001_1 - 0.078 12.9 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain Ser_hydrolase PF06821.11 001285225.1_29523001_1 - 0.1 12.3 0.0 7.1 6.3 0.0 2.2 2 0 0 2 2 2 0 Serine hydrolase Ribosomal_S4e PF00900.18 001265622.1_29622001_2 - 1.8e-40 136.5 0.5 9.5e-40 134.2 0.5 2.0 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.3 001265622.1_29622001_2 - 1.2e-30 104.7 0.1 2.1e-30 104.0 0.1 1.4 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.10 001265622.1_29622001_2 - 3.5e-22 78.1 6.2 9e-22 76.8 6.2 1.8 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.23 001265622.1_29622001_2 - 6e-06 25.7 0.0 1e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 S4 domain KOW PF00467.27 001265622.1_29622001_2 - 8.4e-06 25.4 0.2 2.7e-05 23.8 0.2 1.9 1 0 0 1 1 1 1 KOW motif WND PF07861.9 001265622.1_29622001_2 - 0.12 11.6 0.8 0.21 10.9 0.8 1.3 1 0 0 1 1 1 0 WisP family N-Terminal Region Kelch_1 PF01344.23 001266347.2_29625001_1 - 4.6e-50 166.8 0.6 8.6e-12 44.3 0.0 7.6 8 0 0 8 8 8 7 Kelch motif Kelch_6 PF13964.4 001266347.2_29625001_1 - 6.5e-39 130.8 2.7 1.5e-07 31.3 0.0 8.2 3 3 5 8 8 8 7 Kelch motif Kelch_4 PF13418.4 001266347.2_29625001_1 - 6.7e-26 89.9 0.3 8.6e-05 22.3 0.0 7.2 7 1 1 8 8 8 4 Galactose oxidase, central domain Kelch_2 PF07646.13 001266347.2_29625001_1 - 7.5e-21 73.1 0.1 0.0055 16.5 0.0 7.0 7 0 0 7 7 7 5 Kelch motif Kelch_3 PF13415.4 001266347.2_29625001_1 - 1e-19 70.2 0.1 9.1e-05 22.5 0.0 7.2 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_5 PF13854.4 001266347.2_29625001_1 - 9.1e-11 41.4 2.3 0.0066 16.3 0.0 6.7 7 0 0 7 7 7 2 Kelch motif CHCH PF06747.11 001283998.1_29522001_3 - 2.4e-09 37.0 3.8 4.7e-09 36.0 3.8 1.5 1 0 0 1 1 1 1 CHCH domain MTCP1 PF08991.8 001283998.1_29522001_3 - 0.039 14.0 0.3 0.063 13.4 0.3 1.3 1 0 0 1 1 1 0 Mature-T-Cell Proliferation I type Dynein_IC2 PF11540.6 001261582.1_29626001_1 - 1.1e-14 53.9 0.1 2.5e-14 52.8 0.1 1.7 1 0 0 1 1 1 1 Cytoplasmic dynein 1 intermediate chain 2 WD40 PF00400.30 001261582.1_29626001_1 - 5.2e-06 27.0 9.1 0.17 12.7 0.3 6.1 7 0 0 7 7 7 2 WD domain, G-beta repeat GOLGA2L5 PF15070.4 001328295.1_39725001_1 - 3.9e-10 38.9 0.0 3.9e-10 38.9 0.0 2.1 1 1 0 2 2 2 1 Putative golgin subfamily A member 2-like protein 5 Exonuc_VII_L PF02601.13 001328295.1_39725001_1 - 1.7 8.0 17.3 2.4 7.5 17.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit UDPGT PF00201.16 001112619.2_40424001_2 - 7e-248 823.2 0.4 8.1e-248 823.0 0.4 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001112619.2_40424001_2 - 1.5e-08 34.6 0.0 2.8e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.4 001112619.2_40424001_2 - 0.0019 18.1 0.4 0.0086 15.9 0.4 2.0 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_transf_49 PF13896.4 001279898.1_39725001_1 - 5.3e-102 341.4 0.0 6.6e-102 341.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl-transferase for dystroglycan GspL_C PF12693.5 001279898.1_39725001_1 - 0.16 11.7 0.1 0.3 10.8 0.1 1.4 1 0 0 1 1 1 0 GspL periplasmic domain G-gamma PF00631.20 001329735.1_39723001_1 - 1.5e-14 53.6 0.0 2.2e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 GGL domain DUF4517 PF15006.4 001283492.1_29523001_1 - 1.6e-13 51.0 0.0 2.4e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4517) DUF4517 PF15006.4 001283492.1_29523001_2 - 1.9e-22 80.0 0.0 2.6e-22 79.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4517) DUF4584 PF15223.4 001193705.1_29623001_1 - 2.8e-23 82.9 6.6 4.2e-23 82.3 6.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4584) TP1 PF02079.14 001193705.1_29623001_1 - 0.16 11.8 1.3 0.37 10.5 1.3 1.6 1 0 0 1 1 1 0 Nuclear transition protein 1 FAA_hydrolase PF01557.16 001346886.1_39724001_2 - 2e-56 191.0 0.0 2.7e-56 190.6 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.9 001346886.1_39724001_2 - 2.5e-31 107.8 0.0 4e-31 107.1 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal HIG_1_N PF04588.11 001194755.1_29621001_1 - 1.8e-15 56.8 0.1 2.7e-15 56.2 0.1 1.3 1 0 0 1 1 1 1 Hypoxia induced protein conserved region MHC_I PF00129.16 001279561.1_24223001_2 - 1.4e-89 298.3 0.4 2e-89 297.8 0.4 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001279561.1_24223001_2 - 1.1e-17 64.1 0.0 2.2e-17 63.2 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.3 001279561.1_24223001_2 - 0.00028 20.3 0.0 0.00036 19.9 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain C2-set_2 PF08205.10 001279561.1_24223001_2 - 0.00043 20.2 0.1 0.00083 19.3 0.1 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001279561.1_24223001_2 - 0.0014 18.7 0.0 0.0034 17.4 0.0 1.6 2 0 0 2 2 2 1 Immunoglobulin domain MHC_I_C PF06623.9 001279561.1_24223001_2 - 0.12 12.2 0.1 0.21 11.4 0.1 1.4 1 0 0 1 1 1 0 MHC_I C-terminus Filament PF00038.19 001279670.1_24224001_1 - 1.1e-99 333.8 28.1 1.3e-99 333.6 28.1 1.0 1 0 0 1 1 1 1 Intermediate filament protein Jnk-SapK_ap_N PF09744.7 001279670.1_24224001_1 - 0.014 15.5 26.1 0.039 14.0 7.2 3.4 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 DUF3373 PF11853.6 001279670.1_24224001_1 - 0.65 8.5 6.1 8.5 4.9 6.0 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3373) DUF5082 PF16888.3 001279670.1_24224001_1 - 1.5 9.1 14.4 0.057 13.6 4.0 2.9 2 1 0 3 3 3 0 Domain of unknown function (DUF5082) DUF1664 PF07889.10 001279670.1_24224001_1 - 2.1 8.2 10.0 6.8 6.6 0.3 3.5 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) IMD PF08397.9 001279670.1_24224001_1 - 4.2 6.6 12.2 0.12 11.6 3.8 2.3 1 1 0 2 2 2 0 IRSp53/MIM homology domain TPR_MLP1_2 PF07926.10 001279670.1_24224001_1 - 4.2 7.3 29.4 0.16 11.9 4.0 3.8 2 2 1 3 3 3 0 TPR/MLP1/MLP2-like protein Lzipper-MIP1 PF14389.4 001279670.1_24224001_1 - 8.5 6.6 16.3 0.1 12.7 3.5 3.7 3 2 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 Pkinase PF00069.23 001193662.1_39723001_1 - 2.5e-67 226.9 0.0 3.3e-67 226.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001193662.1_39723001_1 - 4.8e-35 121.0 0.0 6.9e-35 120.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001193662.1_39723001_1 - 1.1e-07 31.4 0.0 2.2e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like BRAP2 PF07576.10 001246552.1_39725001_3 - 7.1e-36 122.3 0.4 1.5e-35 121.2 0.4 1.6 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.17 001246552.1_39725001_3 - 2.5e-21 75.6 7.1 1.2e-20 73.5 7.1 2.2 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.4 001246552.1_39725001_3 - 2.5e-08 33.9 6.9 2.5e-08 33.9 6.9 2.8 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.4 001246552.1_39725001_3 - 1.4e-07 31.1 6.1 1.4e-07 31.1 6.1 2.5 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 001246552.1_39725001_3 - 1.1e-05 24.9 1.8 1.1e-05 24.9 1.8 2.4 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.5 001246552.1_39725001_3 - 1.3e-05 25.3 4.6 1.3e-05 25.3 4.6 2.7 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.4 001246552.1_39725001_3 - 2.1e-05 24.2 5.3 2.1e-05 24.2 5.3 2.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.23 001246552.1_39725001_3 - 9.2e-05 22.1 5.8 9.2e-05 22.1 5.8 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001246552.1_39725001_3 - 0.00098 19.0 6.2 0.00098 19.0 6.2 3.0 1 1 1 2 2 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.5 001246552.1_39725001_3 - 0.0025 17.7 2.5 0.031 14.2 3.1 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger RRM_1 PF00076.20 001246552.1_39725001_3 - 0.011 15.5 0.0 0.025 14.3 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GBP_C PF02841.12 001246552.1_39725001_3 - 0.029 13.6 18.6 0.062 12.6 18.6 1.5 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Reo_sigmaC PF04582.10 001246552.1_39725001_3 - 0.09 12.0 2.2 0.091 12.0 0.7 1.7 2 0 0 2 2 2 0 Reovirus sigma C capsid protein KASH_CCD PF14662.4 001246552.1_39725001_3 - 0.11 12.2 29.1 0.022 14.5 25.3 1.8 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH DUF4407 PF14362.4 001246552.1_39725001_3 - 0.12 11.6 11.0 0.2 10.8 11.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Baculo_PEP_C PF04513.10 001246552.1_39725001_3 - 0.16 11.9 9.5 0.076 12.9 5.4 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus V_ATPase_I PF01496.17 001246552.1_39725001_3 - 0.16 9.7 14.0 0.061 11.1 11.6 1.4 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Prok-RING_4 PF14447.4 001246552.1_39725001_3 - 0.53 10.1 18.0 0.14 11.9 7.3 2.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Peptidase_S46 PF10459.7 001246552.1_39725001_3 - 1.1 7.7 9.7 2 6.8 9.7 1.3 1 0 0 1 1 1 0 Peptidase S46 APG6 PF04111.10 001246552.1_39725001_3 - 2.2 7.4 21.2 4.7 6.4 21.2 1.5 1 0 0 1 1 1 0 Autophagy protein Apg6 KELK PF15796.3 001246552.1_39725001_3 - 4.5 7.7 23.0 0.99 9.8 6.4 3.7 2 1 1 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF342 PF03961.11 001246552.1_39725001_3 - 5.1 5.4 15.9 8.4 4.7 15.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) NPV_P10 PF05531.10 001246552.1_39725001_3 - 5.2 7.5 9.0 2.3e+02 2.2 9.0 3.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein BRCT_assoc PF12820.5 001033969.1_32329001_3 - 3.9e-64 215.3 0.4 3.9e-64 215.3 0.4 3.9 4 0 0 4 4 3 1 Serine-rich domain associated with BRCT BRCT PF00533.24 001033969.1_32329001_3 - 3.4e-16 59.3 0.0 7.2e-07 29.4 0.0 3.3 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain zf-C3HC4 PF00097.23 001033969.1_32329001_3 - 1.4e-09 37.6 9.8 4e-09 36.1 9.8 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001033969.1_32329001_3 - 1.9e-08 33.9 10.4 1.9e-08 33.9 10.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001033969.1_32329001_3 - 7.5e-08 32.3 10.2 1.9e-07 31.0 10.2 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.4 001033969.1_32329001_3 - 5e-07 29.8 8.6 1.7e-06 28.0 8.6 2.1 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.4 001033969.1_32329001_3 - 6.6e-07 29.1 8.7 2.3e-06 27.4 8.7 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 001033969.1_32329001_3 - 1e-06 28.4 7.6 2.2e-06 27.3 7.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001033969.1_32329001_3 - 1.1e-05 25.2 8.0 2.9e-05 23.8 8.0 1.8 1 0 0 1 1 1 1 zinc-RING finger domain BRCT_2 PF16589.3 001033969.1_32329001_3 - 3.3e-05 24.1 0.0 0.37 11.1 0.0 3.0 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain zf-Nse PF11789.6 001033969.1_32329001_3 - 0.00033 20.3 6.2 0.0012 18.5 6.2 1.9 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.4 001033969.1_32329001_3 - 0.00049 19.8 3.3 0.0011 18.6 3.3 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.4 001033969.1_32329001_3 - 0.00049 19.8 7.6 0.0016 18.1 7.6 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.3 001033969.1_32329001_3 - 0.0013 18.7 4.9 0.0035 17.3 4.9 1.7 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-ANAPC11 PF12861.5 001033969.1_32329001_3 - 0.011 15.6 1.6 0.032 14.1 1.6 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.5 001033969.1_32329001_3 - 0.058 13.6 4.9 0.32 11.2 4.9 2.4 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.4 001033969.1_32329001_3 - 0.3 10.7 6.4 1 9.0 6.4 2.0 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_5 PF17121.3 001033969.1_32329001_3 - 2.3 8.1 4.8 6.9 6.5 4.8 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) BRAP2 PF07576.10 001265936.1_29628001_1 - 1.9e-35 120.9 0.4 3.5e-35 120.0 0.4 1.5 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.17 001265936.1_29628001_1 - 7.7e-21 74.1 7.1 2.3e-20 72.5 7.1 1.8 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.4 001265936.1_29628001_1 - 4.8e-08 33.0 6.9 4.8e-08 33.0 6.9 2.5 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 001265936.1_29628001_1 - 2.7e-07 30.2 6.1 2.7e-07 30.2 6.1 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 001265936.1_29628001_1 - 5.4e-06 26.5 4.6 2.5e-05 24.4 4.6 2.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.3 001265936.1_29628001_1 - 2.2e-05 24.0 1.8 2.2e-05 24.0 1.8 2.1 2 0 0 2 2 1 1 RING-like zinc finger zf-RING_UBOX PF13445.4 001265936.1_29628001_1 - 3.2e-05 23.7 0.4 3.2e-05 23.7 0.4 2.7 1 1 1 2 2 1 1 RING-type zinc-finger zf-RING_5 PF14634.4 001265936.1_29628001_1 - 4.1e-05 23.3 5.3 4.1e-05 23.3 5.3 2.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.23 001265936.1_29628001_1 - 0.00018 21.2 5.8 0.00018 21.2 5.8 2.4 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 001265936.1_29628001_1 - 0.0087 16.0 2.7 0.06 13.3 3.1 2.2 2 0 0 2 2 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger RRM_1 PF00076.20 001265936.1_29628001_1 - 0.014 15.1 0.0 0.028 14.1 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.4 001265936.1_29628001_1 - 0.04 13.6 18.1 0.1 12.4 7.5 2.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3H2C3 PF17122.3 001265936.1_29628001_1 - 0.063 13.2 4.1 0.22 11.5 4.1 2.1 1 0 0 1 1 1 0 Zinc-finger GBP_C PF02841.12 001265936.1_29628001_1 - 0.091 12.0 18.5 0.17 11.1 18.5 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Reo_sigmaC PF04582.10 001265936.1_29628001_1 - 0.11 11.7 0.7 0.25 10.6 0.7 1.5 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Baculo_PEP_C PF04513.10 001265936.1_29628001_1 - 0.18 11.7 7.9 0.085 12.8 4.7 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus V_ATPase_I PF01496.17 001265936.1_29628001_1 - 0.2 9.4 12.4 0.34 8.6 12.4 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.4 001265936.1_29628001_1 - 0.58 9.3 11.2 0.91 8.7 11.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) KASH_CCD PF14662.4 001265936.1_29628001_1 - 0.64 9.7 29.2 0.087 12.5 25.3 1.5 2 0 0 2 2 1 0 Coiled-coil region of CCDC155 or KASH Zn_ribbon_17 PF17120.3 001265936.1_29628001_1 - 0.68 9.5 14.9 0.41 10.2 5.4 2.8 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Peptidase_S46 PF10459.7 001265936.1_29628001_1 - 1.9 6.9 8.6 2.9 6.3 8.6 1.2 1 0 0 1 1 1 0 Peptidase S46 Prok-RING_4 PF14447.4 001265936.1_29628001_1 - 2.1 8.1 18.0 0.28 11.0 7.3 2.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 DUF342 PF03961.11 001265936.1_29628001_1 - 8.5 4.7 14.8 13 4.1 14.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) APG6 PF04111.10 001265936.1_29628001_1 - 9.6 5.4 20.9 18 4.5 20.9 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 Toluene_X PF03349.14 001280392.1_39724001_1 - 0.33 9.3 0.7 0.43 8.9 0.7 1.1 1 0 0 1 1 1 0 Outer membrane protein transport protein (OMPP1/FadL/TodX) HEAT_2 PF13646.4 001280392.1_39724001_3 - 1.7e-13 50.6 2.7 5.2e-05 23.4 0.2 3.9 2 1 1 4 4 4 4 HEAT repeats IFRD PF05004.11 001280392.1_39724001_3 - 0.0056 15.7 0.6 1.1 8.1 0.2 2.5 1 1 1 2 2 2 2 Interferon-related developmental regulator (IFRD) DUF3385 PF11865.6 001280392.1_39724001_3 - 0.066 12.9 4.4 0.7 9.6 1.2 3.5 2 2 0 2 2 2 0 Domain of unknown function (DUF3385) HEAT PF02985.20 001280392.1_39724001_3 - 0.4 10.9 3.4 64 4.1 0.0 4.8 5 0 0 5 5 5 0 HEAT repeat Gln-synt_C PF00120.22 001279785.1_39724001_2 - 4.8e-18 65.1 0.0 2.2e-13 49.8 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.17 001279785.1_39724001_2 - 3.7e-12 45.7 0.0 6.4e-12 44.9 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain DUF4207 PF13904.4 001279977.1_39724001_1 - 4.3e-05 23.2 36.8 4.3e-05 23.2 36.8 3.3 2 2 1 3 3 3 2 Domain of unknown function (DUF4207) GKAP PF03359.11 001280111.1_39726001_3 - 4.5e-30 105.3 1.1 4.5e-30 105.3 1.1 2.9 3 0 0 3 3 3 1 Guanylate-kinase-associated protein (GKAP) protein LAS2 PF15792.3 001279819.1_39725001_1 - 5.3e-47 158.2 16.5 1.2e-27 96.2 1.7 3.4 3 0 0 3 3 3 2 Lung adenoma susceptibility protein 2 TANGO2 PF05742.10 001280323.1_39725001_1 - 1.5e-72 244.6 0.0 1.9e-72 244.2 0.0 1.1 1 0 0 1 1 1 1 Transport and Golgi organisation 2 TRM PF02005.14 001280215.1_39726001_3 - 1.1e-65 222.2 3.7 1.1e-55 189.3 0.4 3.0 3 1 0 3 3 3 2 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.14 001280215.1_39726001_3 - 0.00012 21.7 0.1 0.00027 20.6 0.1 1.5 1 1 0 1 1 1 1 Met-10+ like-protein Methyltransf_25 PF13649.4 001280215.1_39726001_3 - 0.0014 19.2 0.2 0.74 10.4 0.0 3.8 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.4 001280215.1_39726001_3 - 0.0041 16.8 0.2 0.018 14.7 0.1 2.2 2 1 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.13 001280215.1_39726001_3 - 0.047 13.2 0.0 0.55 9.7 0.0 2.4 1 1 0 1 1 1 0 Conserved hypothetical protein 95 MTS PF05175.12 001280215.1_39726001_3 - 0.11 11.9 0.3 0.25 10.8 0.1 1.7 2 0 0 2 2 2 0 Methyltransferase small domain zf-C2H2_4 PF13894.4 001280215.1_39726001_3 - 0.75 10.7 14.1 1.1 10.1 0.4 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-BED PF02892.13 001280215.1_39726001_3 - 9.2 6.3 8.6 19 5.3 0.8 2.7 2 0 0 2 2 2 0 BED zinc finger DUF4659 PF15558.4 001328280.1_39725001_2 - 3.4e-138 460.5 96.6 3.4e-138 460.5 96.6 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4659) NRN1 PF15056.4 001328280.1_39725001_2 - 0.085 12.8 6.4 6.8 6.7 0.1 3.9 3 0 0 3 3 3 0 Neuritin protein family NUDE_C PF04880.11 001280356.1_39725001_3 - 6.7e-46 156.9 0.4 6.7e-46 156.9 0.4 2.4 2 0 0 2 2 2 1 NUDE protein, C-terminal conserved region TPR_MLP1_2 PF07926.10 001280356.1_39725001_3 - 0.0022 17.9 6.2 0.0022 17.9 6.2 3.0 1 1 2 3 3 3 1 TPR/MLP1/MLP2-like protein PRKG1_interact PF15898.3 001280356.1_39725001_3 - 0.031 15.0 21.9 0.043 14.6 8.7 2.4 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain Golgin_A5 PF09787.7 001280356.1_39725001_3 - 0.16 11.3 24.4 0.26 10.6 24.4 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF1664 PF07889.10 001280356.1_39725001_3 - 0.28 11.1 7.5 0.14 12.0 4.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Rootletin PF15035.4 001280356.1_39725001_3 - 0.41 10.6 30.5 0.62 10.0 11.5 2.2 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion HALZ PF02183.16 001280356.1_39725001_3 - 0.5 10.5 12.2 0.078 13.1 3.0 2.8 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF2410 PF10307.7 001280356.1_39725001_3 - 0.55 9.9 7.2 2.1 8.0 6.9 1.8 1 1 0 1 1 1 0 Hypothetical protein (DUF2410) ATG16 PF08614.9 001280356.1_39725001_3 - 0.79 9.7 35.7 1.8 8.5 19.3 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Fzo_mitofusin PF04799.11 001280356.1_39725001_3 - 7.3 6.0 12.7 0.51 9.7 4.9 2.3 1 1 1 2 2 2 0 fzo-like conserved region KxDL PF10241.7 001280356.1_39725001_3 - 7.6 6.7 12.5 1.3 9.2 4.9 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein CCDC92 PF14916.4 001280356.1_39725001_3 - 9.8 5.9 8.6 5.1 6.8 0.3 3.1 2 1 1 3 3 3 0 Coiled-coil domain of unknown function Aminotran_1_2 PF00155.19 001109594.1_45725001_1 - 2.2e-49 168.4 0.0 3e-49 168.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II OKR_DC_1 PF01276.18 001109594.1_45725001_1 - 0.0074 14.9 0.0 0.012 14.3 0.0 1.2 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain Alliinase_C PF04864.11 001109594.1_45725001_1 - 0.093 11.4 0.5 0.36 9.5 0.2 1.9 2 0 0 2 2 2 0 Allinase DUF776 PF05604.9 001279967.1_39724001_2 - 5.3e-92 307.0 15.2 7.4e-92 306.6 15.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF776) Ada3 PF10198.7 001279991.1_39725001_1 - 0.051 13.6 0.3 0.16 11.9 0.4 1.7 2 0 0 2 2 2 0 Histone acetyltransferases subunit 3 TMEM132D_C PF15706.3 001279998.1_39725001_3 - 0.045 13.4 0.0 0.17 11.5 0.0 2.0 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term RRM_1 PF00076.20 001280425.1_39724001_2 - 3.4e-11 42.6 0.0 5.3e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CtIP_N PF10482.7 001280338.1_39727001_1 - 2e-55 185.9 19.8 2.9e-55 185.3 19.8 1.2 1 0 0 1 1 1 1 Tumour-suppressor protein CtIP N-terminal domain ZapB PF06005.10 001280338.1_39727001_1 - 0.0094 16.3 14.1 0.066 13.5 0.2 2.6 2 0 0 2 2 2 1 Cell division protein ZapB bZIP_1 PF00170.19 001280338.1_39727001_1 - 0.013 15.4 12.6 0.076 13.0 3.6 2.7 2 0 0 2 2 2 0 bZIP transcription factor DivIC PF04977.13 001280338.1_39727001_1 - 0.037 13.7 5.8 0.16 11.6 0.1 2.5 2 0 0 2 2 2 0 Septum formation initiator JIP_LZII PF16471.3 001280338.1_39727001_1 - 0.057 13.5 4.5 4.8 7.3 0.1 2.5 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II HALZ PF02183.16 001280338.1_39727001_1 - 0.08 13.0 0.3 0.08 13.0 0.3 2.7 3 0 0 3 3 2 0 Homeobox associated leucine zipper bZIP_2 PF07716.13 001280338.1_39727001_1 - 0.21 11.6 9.8 1.8 8.6 1.1 2.9 2 0 0 2 2 2 0 Basic region leucine zipper Atg14 PF10186.7 001280338.1_39727001_1 - 0.83 8.5 8.2 1.4 7.8 8.2 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TSC22 PF01166.16 001280338.1_39727001_1 - 0.89 9.8 9.1 3.9 7.7 1.4 2.5 2 0 0 2 2 2 0 TSC-22/dip/bun family Prominin PF05478.9 001280338.1_39727001_1 - 3.2 5.4 6.1 4.9 4.8 6.1 1.2 1 0 0 1 1 1 0 Prominin Latarcin PF10279.7 001280338.1_39727001_1 - 4.4 7.6 6.5 6.4 7.1 0.6 2.7 2 0 0 2 2 2 0 Latarcin precursor DUF4472 PF14739.4 001280338.1_39727001_1 - 4.9 7.8 12.1 3.1 8.4 8.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) zf-C3HC4_3 PF13920.4 001194214.2_29629001_3 - 2.6e-06 27.0 10.9 2.6e-06 27.0 10.9 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001194214.2_29629001_3 - 1.1e-05 25.0 12.8 2.5e-05 23.9 12.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001194214.2_29629001_3 - 0.0001 21.9 12.6 0.00024 20.7 12.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) BRE1 PF08647.9 001194214.2_29629001_3 - 0.0007 19.5 6.9 0.0007 19.5 6.9 8.3 6 2 1 7 7 7 2 BRE1 E3 ubiquitin ligase EzrA PF06160.10 001194214.2_29629001_3 - 0.00076 17.7 7.9 0.00076 17.7 7.9 5.6 4 1 2 6 6 6 1 Septation ring formation regulator, EzrA zf-RING_5 PF14634.4 001194214.2_29629001_3 - 0.001 18.9 13.1 0.0044 16.8 13.4 2.0 1 1 1 2 2 2 1 zinc-RING finger domain KASH_CCD PF14662.4 001194214.2_29629001_3 - 0.0054 16.5 19.2 0.0054 16.5 19.2 7.2 3 2 4 7 7 5 2 Coiled-coil region of CCDC155 or KASH zf-RING_2 PF13639.4 001194214.2_29629001_3 - 0.0069 16.5 12.1 0.017 15.3 12.1 1.7 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.4 001194214.2_29629001_3 - 0.0078 15.9 10.5 0.017 14.8 10.5 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.4 001194214.2_29629001_3 - 0.02 14.8 9.4 0.056 13.3 9.4 1.8 1 0 0 1 1 1 0 RING-type zinc-finger zf-rbx1 PF12678.5 001194214.2_29629001_3 - 0.046 13.9 7.5 0.12 12.5 7.5 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain Reo_sigmaC PF04582.10 001194214.2_29629001_3 - 0.78 8.9 14.2 13 5.0 0.3 4.8 2 2 3 6 6 6 0 Reovirus sigma C capsid protein zf-C3HC4_4 PF15227.4 001194214.2_29629001_3 - 2.6 8.2 10.5 6.2 6.9 10.5 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING HECT PF00632.23 001271660.1_39728001_3 - 3.4e-93 312.4 0.0 5.6e-93 311.7 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.25 001271660.1_39728001_3 - 9.8e-05 21.7 0.4 0.00036 20.0 0.4 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif EAL PF00563.18 001271660.1_39728001_3 - 0.15 11.4 1.8 1.4 8.3 0.1 2.2 2 0 0 2 2 2 0 EAL domain polyprenyl_synt PF00348.15 001167653.1_49823001_1 - 1.3e-18 66.8 0.3 2e-18 66.3 0.3 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase BCAS2 PF05700.9 001244424.1_49822001_1 - 2.7e-80 268.8 8.0 3.4e-80 268.5 8.0 1.1 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) HAUS2 PF15003.4 001244424.1_49822001_1 - 0.0022 17.6 0.3 0.0034 17.0 0.3 1.3 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 2 Mesd PF10185.7 001244424.1_49822001_1 - 0.037 13.8 2.6 2.9 7.7 0.3 2.2 1 1 1 2 2 2 0 Chaperone for wingless signalling and trafficking of LDL receptor Filament PF00038.19 001244424.1_49822001_1 - 0.076 12.5 9.8 0.12 11.7 9.6 1.4 1 1 0 1 1 1 0 Intermediate filament protein Ribosomal_L29 PF00831.21 001244424.1_49822001_1 - 0.088 12.6 7.7 0.7 9.8 0.7 2.4 2 0 0 2 2 2 0 Ribosomal L29 protein Tup_N PF08581.8 001244424.1_49822001_1 - 0.11 12.7 11.2 0.64 10.2 1.9 3.3 1 1 2 3 3 3 0 Tup N-terminal THOC7 PF05615.11 001244424.1_49822001_1 - 0.13 12.5 10.1 0.018 15.2 3.4 2.3 2 1 0 2 2 2 0 Tho complex subunit 7 CENP-F_leu_zip PF10473.7 001244424.1_49822001_1 - 0.3 11.0 9.4 0.77 9.6 9.5 1.6 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cep57_CLD PF14073.4 001244424.1_49822001_1 - 0.39 10.6 10.4 0.77 9.6 10.4 1.4 1 1 0 1 1 1 0 Centrosome localisation domain of Cep57 OmpH PF03938.12 001244424.1_49822001_1 - 0.74 9.7 4.9 1.2 8.9 4.9 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) PRKG1_interact PF15898.3 001244424.1_49822001_1 - 0.98 10.2 9.2 0.31 11.8 4.9 2.2 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain Cnn_1N PF07989.9 001244424.1_49822001_1 - 1 9.4 8.8 7.3 6.7 2.2 2.5 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Cep57_MT_bd PF06657.11 001244424.1_49822001_1 - 1.5 9.2 9.1 4.2 7.7 1.4 2.9 2 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Spc24 PF08286.9 001244424.1_49822001_1 - 4.5 7.4 8.1 3.5 7.8 0.7 2.6 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Aha1_N PF09229.9 001266884.1_29623001_3 - 1.5e-38 132.0 1.2 2.1e-38 131.4 1.2 1.2 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.9 001266884.1_29623001_3 - 3e-26 92.0 0.7 6.6e-26 90.8 0.4 1.7 2 0 0 2 2 2 1 Activator of Hsp90 ATPase homolog 1-like protein polyprenyl_synt PF00348.15 001266911.1_29624001_3 - 4.7e-18 65.0 0.2 7.3e-18 64.4 0.2 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase adh_short_C2 PF13561.4 001168821.1_40422001_1 - 2.6e-51 174.3 0.1 3.6e-51 173.9 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.23 001168821.1_40422001_1 - 1.4e-42 145.2 0.0 1.9e-42 144.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.8 001168821.1_40422001_1 - 1.6e-07 31.3 0.0 2.3e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 KR domain Lectin_C PF00059.19 001197180.1_39529001_1 - 2.8e-171 558.7 50.9 5.5e-25 88.1 0.9 8.7 9 0 0 9 9 9 8 Lectin C-type domain fn2 PF00040.17 001197180.1_39529001_1 - 2.8e-14 53.0 7.6 1.1e-13 51.1 7.6 2.2 1 0 0 1 1 1 1 Fibronectin type II domain UL45 PF05473.10 001197180.1_39529001_1 - 3.1e-11 43.1 9.9 1.9e-06 27.6 0.0 6.8 4 2 2 6 6 6 2 UL45 protein, carbohydrate-binding C-type lectin-like Ricin_B_lectin PF00652.20 001197180.1_39529001_1 - 1.7e-08 34.6 0.1 5.1e-08 33.1 0.1 1.8 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Xlink PF00193.15 001197180.1_39529001_1 - 1.9e-06 28.0 10.6 0.18 12.1 0.1 7.8 8 0 0 8 8 8 1 Extracellular link domain Chordopox_A33R PF05966.10 001197180.1_39529001_1 - 3.9e-05 22.9 2.9 6.1 5.9 0.0 5.0 6 0 0 6 6 6 2 Chordopoxvirus A33R protein DUF4366 PF14283.4 001197180.1_39529001_1 - 0.0084 15.5 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) CDtoxinA PF03498.12 001197180.1_39529001_1 - 0.019 14.4 0.9 0.051 13.0 0.1 2.1 2 0 0 2 2 2 0 Cytolethal distending toxin A/C domain DUF3149 PF11346.6 001197180.1_39529001_1 - 1.5 8.4 3.3 4.1 7.0 3.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) Tiny_TM_bacill PF09680.8 001197180.1_39529001_1 - 6.7 6.3 8.5 12 5.5 8.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (Tiny_TM_bacill) DSPc PF00782.18 001285229.1_29523001_2 - 3.1e-09 36.6 0.0 4.6e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DSPc PF00782.18 001285229.1_29523001_3 - 0.0002 21.1 0.0 0.00029 20.5 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Skp1_POZ PF03931.13 001252005.1_39722001_3 - 1.3e-10 41.1 0.0 1.9e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain DSS1_SEM1 PF05160.11 001266805.1_29621001_1 - 1.8e-22 79.0 18.4 2.8e-22 78.4 18.4 1.3 1 0 0 1 1 1 1 DSS1/SEM1 family Skp1_POZ PF03931.13 001198677.1_29622001_2 - 1.5e-10 41.0 0.0 2.1e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain PAF PF15715.3 001190743.2_29622001_1 - 5e-35 119.8 2.6 7.2e-35 119.3 2.6 1.2 1 0 0 1 1 1 1 PCNA-associated factor Lectin_C PF00059.19 001255969.1_49829001_1 - 3.9e-171 558.2 52.3 1.5e-24 86.7 0.3 9.1 9 0 0 9 9 9 8 Lectin C-type domain fn2 PF00040.17 001255969.1_49829001_1 - 1.1e-15 57.4 10.0 4.4e-15 55.5 10.0 2.2 1 0 0 1 1 1 1 Fibronectin type II domain Ricin_B_lectin PF00652.20 001255969.1_49829001_1 - 5e-08 33.1 0.6 1.3e-07 31.8 0.6 1.7 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain UL45 PF05473.10 001255969.1_49829001_1 - 5.2e-08 32.6 13.1 1.8e-05 24.4 0.0 6.6 5 3 2 7 7 7 1 UL45 protein, carbohydrate-binding C-type lectin-like Xlink PF00193.15 001255969.1_49829001_1 - 0.00052 20.2 15.5 0.3 11.4 0.1 7.7 9 0 0 9 9 9 1 Extracellular link domain Chordopox_A33R PF05966.10 001255969.1_49829001_1 - 0.00059 19.0 4.7 2.3 7.3 0.1 5.1 6 0 0 6 6 6 2 Chordopoxvirus A33R protein DUF4366 PF14283.4 001255969.1_49829001_1 - 0.0082 15.5 0.0 0.018 14.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) CDtoxinA PF03498.12 001255969.1_49829001_1 - 0.017 14.6 0.2 0.095 12.2 0.2 2.3 1 0 0 1 1 1 0 Cytolethal distending toxin A/C domain Intimin_C PF07979.9 001255969.1_49829001_1 - 0.18 12.1 9.2 24 5.3 0.0 5.8 7 0 0 7 7 7 0 Intimin C-type lectin domain HECT PF00632.23 001279559.1_24229001_1 - 9.8e-99 330.6 0.3 1.4e-98 330.1 0.3 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.24 001279559.1_24229001_1 - 1.4e-47 159.1 31.1 7.4e-13 48.1 4.2 4.9 4 0 0 4 4 4 4 WW domain Ald_Xan_dh_C2 PF02738.16 001279676.1_24229001_1 - 1.2e-188 627.9 0.0 1.5e-188 627.6 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 001279676.1_24229001_1 - 7.1e-45 152.7 0.0 2.9e-44 150.7 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.20 001279676.1_24229001_1 - 1.2e-32 112.4 0.1 2.5e-32 111.4 0.1 1.6 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.18 001279676.1_24229001_1 - 6.5e-31 106.0 0.8 1.8e-30 104.6 0.8 1.8 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.15 001279676.1_24229001_1 - 5.1e-28 97.1 0.0 1.4e-27 95.7 0.0 1.8 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.25 001279676.1_24229001_1 - 8.9e-09 35.1 3.5 2.5e-08 33.6 0.1 3.0 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Transferrin PF00405.15 001303546.1_24225001_1 - 4.5e-268 887.1 11.7 1.1e-174 580.1 0.4 2.0 2 0 0 2 2 2 2 Transferrin Phosphonate-bd PF12974.5 001303546.1_24225001_1 - 1e-12 48.1 0.0 5.6e-06 26.0 0.0 2.6 2 1 0 2 2 2 2 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.18 001303546.1_24225001_1 - 0.0096 15.2 0.1 1.5 8.0 0.0 2.7 2 1 0 2 2 2 2 Bacterial extracellular solute-binding proteins, family 3 Nup153 PF08604.8 001300774.1_24229001_1 - 4.5e-235 781.1 40.4 4.5e-235 781.1 40.4 4.7 3 1 0 4 4 4 1 Nucleoporin Nup153-like zf-RanBP PF00641.16 001300774.1_24229001_1 - 5.8e-44 146.9 38.0 2.2e-12 45.9 1.0 4.7 4 0 0 4 4 4 4 Zn-finger in Ran binding protein and others Nup_retrotrp_bd PF10599.7 001300774.1_24229001_1 - 1.5e-22 79.9 21.5 1.5e-22 79.9 21.5 12.7 6 2 3 9 9 9 1 Retro-transposon transporting motif HTH_IclR PF09339.8 001300774.1_24229001_1 - 0.15 11.8 0.1 0.33 10.6 0.1 1.6 1 0 0 1 1 1 0 IclR helix-turn-helix domain Vps36-NZF-N PF16988.3 001300774.1_24229001_1 - 10 5.5 23.5 14 5.0 0.1 4.9 4 0 0 4 4 4 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain XRCC4 PF06632.10 001279666.1_24223001_1 - 7.6e-160 531.1 9.3 8.5e-160 531.0 9.3 1.0 1 0 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF927 PF06048.9 001279666.1_24223001_1 - 0.015 14.7 0.3 0.023 14.1 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF927) IncA PF04156.12 001279666.1_24223001_1 - 6.9 6.3 10.3 0.29 10.7 4.2 1.7 2 0 0 2 2 2 0 IncA protein CtIP_N PF10482.7 001279736.1_24226001_1 - 8.3e-53 177.4 21.8 8.3e-53 177.4 21.8 2.7 2 1 0 2 2 2 1 Tumour-suppressor protein CtIP N-terminal domain SAE2 PF08573.8 001279736.1_24226001_1 - 4.6e-05 24.4 0.5 4.6e-05 24.4 0.5 5.7 5 1 1 6 6 6 2 DNA repair protein endonuclease SAE2/CtIP C-terminus E1_DerP2_DerF2 PF02221.13 001279747.1_24221001_1 - 1.7e-14 54.3 0.2 2e-14 54.0 0.2 1.1 1 0 0 1 1 1 1 ML domain DRMBL PF07522.12 001279748.1_24225001_1 - 4.7e-19 68.6 0.2 9.4e-19 67.6 0.2 1.5 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.5 001279748.1_24225001_1 - 2.6e-07 30.2 0.0 1.1e-06 28.2 0.0 2.0 3 0 0 3 3 3 1 Beta-lactamase superfamily domain Lactamase_B PF00753.25 001279748.1_24225001_1 - 0.0066 16.3 0.1 0.058 13.3 0.1 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily DUF3290 PF11694.6 001279748.1_24225001_1 - 0.027 14.3 0.1 0.41 10.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) Pkinase PF00069.23 001279685.1_24224001_1 - 1.7e-54 184.8 0.2 4e-54 183.6 0.2 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001279685.1_24224001_1 - 8e-36 123.5 0.1 1.9e-29 102.7 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase dsrm PF00035.24 001279685.1_24224001_1 - 5.9e-28 97.2 7.7 1.5e-13 51.1 0.0 3.8 4 0 0 4 4 4 2 Double-stranded RNA binding motif Kinase-like PF14531.4 001279685.1_24224001_1 - 9.6e-05 21.7 0.1 0.0037 16.5 0.0 2.4 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.12 001279685.1_24224001_1 - 0.02 14.1 0.0 0.043 13.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 001279685.1_24224001_1 - 0.062 12.8 0.4 0.65 9.4 0.1 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pox_ser-thr_kin PF05445.9 001279685.1_24224001_1 - 0.1 11.4 0.6 4.5 6.0 0.0 2.1 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase DND1_DSRM PF14709.5 001279685.1_24224001_1 - 0.17 12.1 0.5 2.3 8.4 0.0 2.7 2 2 0 2 2 2 0 double strand RNA binding domain from DEAD END PROTEIN 1 Dynamin_M PF01031.18 001279761.1_24224001_1 - 2.1e-88 296.1 11.5 2.1e-88 296.1 11.5 1.8 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.21 001279761.1_24224001_1 - 8.1e-50 169.0 0.2 8.1e-50 169.0 0.2 2.6 3 0 0 3 3 3 1 Dynamin family GED PF02212.16 001279761.1_24224001_1 - 3.6e-26 91.0 1.6 3.6e-26 91.0 1.6 2.4 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.21 001279761.1_24224001_1 - 0.00028 20.8 3.5 0.0016 18.4 0.6 3.3 3 1 0 3 3 3 1 50S ribosome-binding GTPase AAA_21 PF13304.4 001279761.1_24224001_1 - 0.012 15.3 0.1 0.037 13.7 0.1 1.8 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF2120 PF09893.7 001279761.1_24224001_1 - 0.02 14.8 0.3 0.12 12.4 0.3 2.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) AAA_29 PF13555.4 001279761.1_24224001_1 - 0.022 14.3 0.1 0.049 13.2 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.4 001279761.1_24224001_1 - 0.075 13.3 2.9 0.84 9.9 0.0 3.0 3 1 0 3 3 3 0 AAA ATPase domain Usher PF00577.18 001279761.1_24224001_1 - 0.12 11.1 0.1 0.18 10.5 0.1 1.2 1 0 0 1 1 1 0 Outer membrane usher protein ABC_tran PF00005.25 001279761.1_24224001_1 - 0.24 11.8 3.1 0.25 11.7 0.0 2.6 2 1 0 2 2 2 0 ABC transporter PP_kinase_N PF13089.4 001279761.1_24224001_1 - 1.6 8.9 6.3 1.2 9.4 1.4 3.1 2 1 1 3 3 3 0 Polyphosphate kinase N-terminal domain PARP PF00644.18 001279609.1_24226001_1 - 5.6e-23 81.5 5.9 5.7e-21 75.0 5.9 2.3 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.18 001279609.1_24226001_1 - 2.2e-15 56.8 3.1 1.4e-12 47.8 2.1 2.7 2 0 0 2 2 2 2 WWE domain ABC_membrane PF00664.21 001279682.1_24225001_3 - 3e-55 187.7 0.4 4.3e-55 187.1 0.4 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.25 001279682.1_24225001_3 - 2.9e-33 115.2 0.0 5.5e-33 114.2 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.17 001279682.1_24225001_3 - 1.6e-05 24.3 0.1 0.032 13.5 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.4 001279682.1_24225001_3 - 9.2e-05 22.6 0.3 0.00091 19.4 0.3 2.4 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.4 001279682.1_24225001_3 - 0.0001 21.8 0.1 0.00021 20.8 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.4 001279682.1_24225001_3 - 0.00026 21.3 1.6 0.00089 19.5 1.4 2.1 2 1 0 2 2 1 1 AAA ATPase domain AAA_30 PF13604.4 001279682.1_24225001_3 - 0.00029 20.5 5.0 0.0056 16.3 5.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.4 001279682.1_24225001_3 - 0.00032 20.2 0.5 0.007 15.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.4 001279682.1_24225001_3 - 0.0011 18.7 0.1 0.0032 17.2 0.0 1.8 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.4 001279682.1_24225001_3 - 0.0011 18.5 0.0 0.0015 18.1 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.4 001279682.1_24225001_3 - 0.0065 16.9 0.0 0.013 15.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.4 001279682.1_24225001_3 - 0.032 14.3 0.0 0.071 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.20 001279682.1_24225001_3 - 0.046 13.2 0.0 0.079 12.5 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ABC_ATPase PF09818.7 001279682.1_24225001_3 - 0.11 11.2 0.1 7.6 5.1 0.0 2.2 2 0 0 2 2 2 0 Predicted ATPase of the ABC class TIR_2 PF13676.4 001279568.1_24222001_1 - 1e-10 41.7 0.0 1.5e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 TIR domain TIR PF01582.18 001279568.1_24222001_1 - 1.5e-05 24.7 0.0 2.3e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 TIR domain Radical_SAM PF04055.19 001279645.1_24223001_1 - 4.3e-16 59.6 0.1 1.6e-15 57.8 0.1 1.9 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.4 001279645.1_24223001_1 - 3.5e-07 30.5 0.1 6.4e-07 29.6 0.1 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.4 001279645.1_24223001_1 - 6.4e-07 29.4 0.2 3.9e-05 23.6 0.0 2.3 2 0 0 2 2 2 1 4Fe-4S single cluster domain HD PF01966.20 001279619.1_24224001_1 - 1.4e-18 67.1 0.0 4e-18 65.7 0.0 1.8 2 0 0 2 2 2 1 HD domain SAM_2 PF07647.15 001279619.1_24224001_1 - 3.1e-10 39.9 0.0 6.3e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 001279619.1_24224001_1 - 2.4e-09 37.4 0.0 5.6e-09 36.2 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDEase_I PF00233.17 001279619.1_24224001_1 - 0.0085 15.7 0.0 0.018 14.6 0.0 1.5 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Ste50p-SAM PF09235.8 001279619.1_24224001_1 - 0.036 14.2 0.0 0.1 12.7 0.0 1.8 1 0 0 1 1 1 0 Ste50p, sterile alpha motif DUF3583 PF12126.6 001279725.1_24226001_1 - 4.3e-182 604.7 10.0 6.3e-182 604.2 10.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3583) zf-B_box PF00643.22 001279725.1_24226001_1 - 5.5e-08 32.7 4.3 5.5e-08 32.7 4.3 3.8 3 1 0 3 3 3 2 B-box zinc finger zf-C3HC4_3 PF13920.4 001279725.1_24226001_1 - 0.00013 21.6 10.9 0.00013 21.6 10.9 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 001279725.1_24226001_1 - 0.0032 17.1 13.0 0.0032 17.1 13.0 3.0 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 001279725.1_24226001_1 - 0.0074 16.1 12.3 0.0074 16.1 12.3 3.3 3 0 0 3 3 3 2 zinc-RING finger domain OmpH PF03938.12 001279725.1_24226001_1 - 0.036 14.0 4.1 0.089 12.7 4.1 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Cep57_CLD_2 PF14197.4 001279725.1_24226001_1 - 1.2 9.2 7.9 0.12 12.3 2.2 2.4 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 BST2 PF16716.3 001279631.1_24222001_1 - 7.6e-37 125.6 8.5 1e-36 125.2 8.5 1.2 1 0 0 1 1 1 1 Bone marrow stromal antigen 2 MAD PF05557.11 001279631.1_24222001_1 - 9.2e-05 20.9 4.3 0.00011 20.6 4.3 1.0 1 0 0 1 1 1 1 Mitotic checkpoint protein ATG16 PF08614.9 001279631.1_24222001_1 - 0.0005 20.2 5.5 0.00076 19.6 5.5 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) CALCOCO1 PF07888.9 001279631.1_24222001_1 - 0.0005 18.6 2.6 0.00059 18.4 2.6 1.0 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like DUF3450 PF11932.6 001279631.1_24222001_1 - 0.0035 16.6 3.1 0.0038 16.4 2.6 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3450) TPR_MLP1_2 PF07926.10 001279631.1_24222001_1 - 0.0039 17.1 4.1 0.0081 16.1 4.1 1.5 1 1 0 1 1 1 1 TPR/MLP1/MLP2-like protein TMF_TATA_bd PF12325.6 001279631.1_24222001_1 - 0.0042 17.2 4.3 0.0069 16.5 4.3 1.3 1 1 0 1 1 1 1 TATA element modulatory factor 1 TATA binding IncA PF04156.12 001279631.1_24222001_1 - 0.0049 16.5 11.2 0.0099 15.6 11.2 1.6 1 1 0 1 1 1 1 IncA protein DUF4618 PF15397.4 001279631.1_24222001_1 - 0.0052 16.1 2.6 0.0065 15.8 2.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) Spc7 PF08317.9 001279631.1_24222001_1 - 0.0058 15.4 3.1 0.0075 15.0 3.1 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein PRKG1_interact PF15898.3 001279631.1_24222001_1 - 0.0079 17.0 4.1 0.012 16.4 4.1 1.2 1 0 0 1 1 1 1 cGMP-dependent protein kinase interacting domain CCDC-167 PF15188.4 001279631.1_24222001_1 - 0.0086 16.3 2.5 0.012 15.8 1.7 1.6 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 167 Bap31 PF05529.10 001279631.1_24222001_1 - 0.0097 15.4 4.0 0.019 14.5 4.0 1.4 1 0 0 1 1 1 1 B-cell receptor-associated protein 31-like DUF3584 PF12128.6 001279631.1_24222001_1 - 0.011 13.2 2.2 0.012 13.0 2.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CENP-F_leu_zip PF10473.7 001279631.1_24222001_1 - 0.012 15.5 2.4 0.012 15.5 2.4 1.9 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FlaC_arch PF05377.9 001279631.1_24222001_1 - 0.013 15.8 1.0 0.47 10.8 0.6 2.5 1 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Golgin_A5 PF09787.7 001279631.1_24222001_1 - 0.016 14.5 3.7 0.02 14.2 3.7 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 Filament PF00038.19 001279631.1_24222001_1 - 0.019 14.4 6.0 0.058 12.8 5.9 1.6 1 1 0 1 1 1 0 Intermediate filament protein Jnk-SapK_ap_N PF09744.7 001279631.1_24222001_1 - 0.021 14.9 3.1 0.029 14.5 3.1 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 FliJ PF02050.14 001279631.1_24222001_1 - 0.026 14.6 3.8 0.049 13.7 3.8 1.3 1 1 0 1 1 1 0 Flagellar FliJ protein NRBF2 PF08961.8 001279631.1_24222001_1 - 0.03 13.8 0.2 0.04 13.4 0.2 1.3 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator CASP_C PF08172.10 001279631.1_24222001_1 - 0.031 13.5 0.7 0.031 13.5 0.7 1.5 1 1 0 1 1 1 0 CASP C terminal Reo_sigmaC PF04582.10 001279631.1_24222001_1 - 0.033 13.5 0.6 0.04 13.2 0.6 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein HAUS-augmin3 PF14932.4 001279631.1_24222001_1 - 0.034 13.5 3.8 0.041 13.3 3.8 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Spc24 PF08286.9 001279631.1_24222001_1 - 0.035 14.2 1.9 0.035 14.2 1.9 2.0 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Tropomyosin_1 PF12718.5 001279631.1_24222001_1 - 0.037 14.0 2.4 0.037 14.0 2.4 1.8 1 1 1 2 2 2 0 Tropomyosin like CENP-H PF05837.10 001279631.1_24222001_1 - 0.039 14.2 5.9 0.08 13.2 5.7 1.6 1 1 1 2 2 2 0 Centromere protein H (CENP-H) EMP24_GP25L PF01105.22 001279631.1_24222001_1 - 0.041 13.7 0.9 0.067 13.0 0.9 1.4 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD THOC7 PF05615.11 001279631.1_24222001_1 - 0.049 13.8 3.4 0.07 13.3 3.4 1.2 1 0 0 1 1 1 0 Tho complex subunit 7 Lipoprotein_7 PF01540.14 001279631.1_24222001_1 - 0.049 12.8 0.6 0.062 12.5 0.6 1.1 1 0 0 1 1 1 0 Adhesin lipoprotein Tropomyosin PF00261.18 001279631.1_24222001_1 - 0.054 12.7 5.4 0.2 10.8 1.5 1.8 1 1 0 1 1 1 0 Tropomyosin APG6 PF04111.10 001279631.1_24222001_1 - 0.067 12.4 3.8 0.085 12.1 3.8 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Seryl_tRNA_N PF02403.20 001279631.1_24222001_1 - 0.07 13.2 2.2 0.098 12.8 2.2 1.3 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Cob_adeno_trans PF01923.16 001279631.1_24222001_1 - 0.072 13.1 0.8 0.095 12.7 0.8 1.2 1 0 0 1 1 1 0 Cobalamin adenosyltransferase DUF4200 PF13863.4 001279631.1_24222001_1 - 0.085 13.1 3.8 0.14 12.4 3.8 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) DUF1647 PF07801.9 001279631.1_24222001_1 - 0.095 12.4 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1647) GAS PF13851.4 001279631.1_24222001_1 - 0.1 11.8 5.6 0.068 12.4 2.0 1.8 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding GrpE PF01025.17 001279631.1_24222001_1 - 0.12 11.9 4.4 0.06 12.9 1.8 1.7 1 1 1 2 2 2 0 GrpE Lebercilin PF15619.4 001279631.1_24222001_1 - 0.12 11.9 6.3 0.09 12.3 3.2 1.7 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Mnd1 PF03962.13 001279631.1_24222001_1 - 0.15 11.8 3.0 0.19 11.4 3.0 1.1 1 0 0 1 1 1 0 Mnd1 family Tektin PF03148.12 001279631.1_24222001_1 - 0.16 10.5 6.6 0.57 8.7 1.4 2.0 1 1 1 2 2 2 0 Tektin family V_ATPase_I PF01496.17 001279631.1_24222001_1 - 0.17 9.6 1.2 0.2 9.4 1.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1664 PF07889.10 001279631.1_24222001_1 - 0.17 11.7 2.9 3.1 7.7 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF972 PF06156.11 001279631.1_24222001_1 - 0.17 12.4 2.1 0.26 11.8 0.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Cluap1 PF10234.7 001279631.1_24222001_1 - 0.17 11.1 4.8 0.57 9.4 4.8 1.7 1 1 0 1 1 1 0 Clusterin-associated protein-1 DUF4472 PF14739.4 001279631.1_24222001_1 - 0.18 12.4 4.7 2.5 8.7 1.3 2.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) DUF2205 PF10224.7 001279631.1_24222001_1 - 0.24 11.3 4.9 0.53 10.2 2.1 2.1 1 1 1 2 2 2 0 Predicted coiled-coil protein (DUF2205) Nup54 PF13874.4 001279631.1_24222001_1 - 0.24 11.3 5.6 0.47 10.4 3.0 1.8 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 ZapB PF06005.10 001279631.1_24222001_1 - 0.26 11.6 6.4 0.22 11.9 1.9 2.2 1 1 1 2 2 2 0 Cell division protein ZapB KLRAQ PF10205.7 001279631.1_24222001_1 - 0.39 10.8 4.2 0.78 9.9 1.2 2.1 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein SlyX PF04102.10 001279631.1_24222001_1 - 0.41 11.2 5.7 0.68 10.5 0.5 2.4 1 1 2 3 3 3 0 SlyX Prefoldin_2 PF01920.18 001279631.1_24222001_1 - 0.46 10.3 5.4 1.5 8.7 5.4 1.7 1 1 0 1 1 1 0 Prefoldin subunit KELK PF15796.3 001279631.1_24222001_1 - 0.66 10.4 6.0 0.56 10.6 2.0 2.0 1 1 1 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase ABC_tran_CTD PF16326.3 001279631.1_24222001_1 - 0.67 10.1 5.2 8 6.7 4.7 2.6 1 1 1 2 2 2 0 ABC transporter C-terminal domain ADIP PF11559.6 001279631.1_24222001_1 - 0.79 9.7 6.8 0.48 10.4 2.0 1.8 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DivIC PF04977.13 001279631.1_24222001_1 - 1.4 8.6 7.5 2.8 7.7 2.4 3.0 1 1 2 3 3 3 0 Septum formation initiator CLZ PF16526.3 001279631.1_24222001_1 - 1.7 8.9 6.1 0.31 11.3 1.7 2.0 2 1 1 3 3 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels OmpH PF03938.12 001279631.1_24222001_1 - 1.8 8.4 7.2 6 6.7 7.2 1.7 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Dickkopf_N PF04706.10 001279669.1_24224001_1 - 4.1e-17 62.3 16.8 4.1e-17 62.3 16.8 3.5 4 1 1 5 5 5 2 Dickkopf N-terminal cysteine-rich region LRR_8 PF13855.4 001279583.1_24226001_1 - 1.7e-50 168.5 96.2 2.7e-11 42.9 0.3 10.6 4 2 10 14 14 14 13 Leucine rich repeat TIR PF01582.18 001279583.1_24226001_1 - 1.3e-35 122.6 0.1 2.2e-35 121.9 0.1 1.3 1 0 0 1 1 1 1 TIR domain LRR_4 PF12799.5 001279583.1_24226001_1 - 2.7e-30 103.7 52.9 1.9e-06 27.9 1.5 11.7 8 2 5 13 13 13 10 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001279583.1_24226001_1 - 4.1e-11 42.6 14.5 4.7e-05 22.8 0.0 4.6 3 2 2 5 5 5 4 Leucine-rich repeat TIR_2 PF13676.4 001279583.1_24226001_1 - 2.6e-09 37.2 0.1 4.8e-09 36.3 0.1 1.4 1 0 0 1 1 1 1 TIR domain LRR_1 PF00560.31 001279583.1_24226001_1 - 2.9e-08 32.9 51.2 0.16 12.4 0.4 15.3 13 4 1 14 14 14 3 Leucine Rich Repeat LRR_6 PF13516.4 001279583.1_24226001_1 - 1.6e-06 27.6 49.1 0.33 11.0 0.4 13.4 16 0 0 16 16 16 4 Leucine Rich repeat DUF1863 PF08937.9 001279583.1_24226001_1 - 0.00013 22.2 0.5 0.00056 20.1 0.5 2.0 1 1 0 1 1 1 1 MTH538 TIR-like domain (DUF1863) RRM_1 PF00076.20 001270516.1_32924001_2 - 1.9e-18 65.9 0.1 3.4e-18 65.1 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM1CTR PF08081.9 001270516.1_32924001_2 - 0.0011 18.9 9.8 0.0011 18.9 9.8 5.0 5 1 1 6 6 6 1 RBM1CTR (NUC064) family RRM_7 PF16367.3 001270516.1_32924001_2 - 0.0029 17.6 0.0 0.0064 16.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.4 001270516.1_32924001_2 - 0.014 14.8 0.0 0.031 13.8 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LRAT PF04970.11 144632.1_26229120_1 - 1e-07 32.2 0.0 2.6e-05 24.4 0.0 2.2 1 1 0 1 1 1 1 Lecithin retinol acyltransferase adh_short PF00106.23 001163052.1_39522001_1 - 7.9e-44 149.3 0.1 1e-43 148.9 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001163052.1_39522001_1 - 1.8e-31 109.4 0.0 2.2e-31 109.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001163052.1_39522001_1 - 3.8e-13 49.6 0.1 6e-13 49.0 0.1 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.23 001283663.1_29524001_3 - 1.5e-44 151.7 0.1 2e-44 151.2 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001283663.1_29524001_3 - 1.1e-32 113.3 0.0 1.6e-32 112.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001283663.1_29524001_3 - 4.4e-14 52.7 0.1 6.5e-14 52.1 0.1 1.2 1 0 0 1 1 1 1 KR domain Pkinase PF00069.23 001261722.1_29627001_2 - 1.8e-70 237.2 0.0 2.5e-70 236.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001261722.1_29627001_2 - 3.5e-53 180.4 0.0 4.8e-53 179.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1241 PF06840.9 001261722.1_29627001_2 - 0.00018 21.0 0.1 0.00034 20.2 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Kinase-like PF14531.4 001261722.1_29627001_2 - 0.067 12.4 0.0 0.25 10.5 0.0 1.9 2 0 0 2 2 2 0 Kinase-like VWA_2 PF13519.4 001283247.1_29525001_3 - 7.2e-19 68.3 0.0 1.4e-17 64.2 0.0 2.3 2 0 0 2 2 2 1 von Willebrand factor type A domain Beta-Casp PF10996.6 001280424.1_39725001_3 - 1e-25 90.0 0.1 5.3e-25 87.7 0.0 2.3 3 0 0 3 3 3 1 Beta-Casp domain Lactamase_B_6 PF16661.3 001280424.1_39725001_3 - 2.5e-23 82.4 0.0 5e-23 81.4 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.10 001280424.1_39725001_3 - 3.9e-17 61.8 0.0 7.5e-17 60.9 0.0 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.25 001280424.1_39725001_3 - 3.8e-11 43.2 0.0 1.8e-08 34.5 0.0 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.5 001280424.1_39725001_3 - 2.3e-08 33.6 0.8 4.9e-08 32.6 0.1 1.9 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.4 001280424.1_39725001_3 - 9.1e-05 22.3 0.0 0.0011 18.8 0.0 2.5 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.3 001280424.1_39725001_3 - 0.0011 18.1 0.0 0.002 17.2 0.0 1.4 1 0 0 1 1 1 1 Putative beta-lactamase-like family zf-RanBP PF00641.16 001328286.1_39724001_2 - 2.3e-12 45.9 9.3 3.6e-12 45.2 9.3 1.3 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RRM_1 PF00076.20 001328286.1_39724001_2 - 3.5e-11 42.6 0.0 1.2e-10 40.9 0.0 1.9 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Laminin_EGF PF00053.22 001271715.1_49829001_1 - 8.2e-85 278.7 233.0 1e-11 44.6 14.4 12.4 13 0 0 13 13 13 11 Laminin EGF domain Laminin_N PF00055.15 001271715.1_49829001_1 - 1.3e-83 280.1 0.0 4.9e-83 278.2 0.0 2.1 1 0 0 1 1 1 1 Laminin N-terminal (Domain VI) Laminin_B PF00052.16 001271715.1_49829001_1 - 1.9e-30 105.4 0.0 4.3e-30 104.2 0.0 1.7 1 0 0 1 1 1 1 Laminin B (Domain IV) LOH1CR12 PF10158.7 001271715.1_49829001_1 - 1 9.2 13.0 0.047 13.6 0.9 3.2 2 1 1 3 3 3 0 Tumour suppressor protein Cpn60_TCP1 PF00118.22 001258189.1_29627001_2 - 5.4e-159 529.8 8.6 6.7e-159 529.5 8.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FOXP-CC PF16159.3 001122936.1_37925001_1 - 3.3e-35 120.4 4.2 3.3e-35 120.4 4.2 5.0 3 1 2 5 5 5 1 FOXP coiled-coil domain Forkhead PF00250.16 001122936.1_37925001_1 - 2.7e-28 98.0 0.2 1.1e-27 96.1 0.2 2.0 1 0 0 1 1 1 1 Forkhead domain CobT PF06213.10 001122936.1_37925001_1 - 0.33 10.1 34.9 0.61 9.3 34.9 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Plasmodium_Vir PF05795.9 001122936.1_37925001_1 - 0.45 9.7 12.5 1.1 8.4 10.4 2.3 2 0 0 2 2 2 0 Plasmodium vivax Vir protein RR_TM4-6 PF06459.10 001122936.1_37925001_1 - 0.66 9.6 26.9 1.6 8.3 26.9 1.7 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4746 PF15928.3 001122936.1_37925001_1 - 2.1 7.6 16.5 4.5 6.5 16.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TT_ORF1 PF02956.12 001122936.1_37925001_1 - 5.8 5.3 26.2 9.4 4.6 26.2 1.2 1 0 0 1 1 1 0 TT viral orf 1 SID-1_RNA_chan PF13965.4 001122936.1_37925001_1 - 9.9 4.3 13.2 15 3.7 13.2 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Ras PF00071.20 001243273.1_49827001_3 - 1.4e-57 193.7 0.3 1.9e-57 193.2 0.3 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001243273.1_49827001_3 - 5.6e-35 120.0 0.1 8.4e-35 119.5 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001243273.1_49827001_3 - 2.3e-14 53.1 0.1 3.4e-14 52.5 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001243273.1_49827001_3 - 0.00013 21.3 0.0 0.00021 20.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.25 001243273.1_49827001_3 - 0.00015 21.3 0.1 0.00033 20.1 0.1 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001243273.1_49827001_3 - 0.00085 19.3 0.1 0.0013 18.6 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001243273.1_49827001_3 - 0.0072 15.6 0.1 0.01 15.1 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF258 PF03193.14 001243273.1_49827001_3 - 0.0091 15.8 0.1 0.87 9.3 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF258 FeoB_N PF02421.16 001243273.1_49827001_3 - 0.016 14.6 0.2 0.1 12.0 0.2 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B Iso_dh PF00180.18 001164007.1_49824001_2 - 7.8e-77 258.6 0.0 9.2e-77 258.4 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Phe_ZIP PF08916.9 001164007.1_49824001_2 - 0.25 12.0 0.7 0.8 10.3 0.2 2.0 2 0 0 2 2 2 0 Phenylalanine zipper BEX PF04538.10 001284162.1_29523001_2 - 9.4e-43 145.7 39.6 1.5e-37 128.9 26.2 3.0 1 1 1 2 2 2 2 Brain expressed X-linked like family Calsequestrin PF01216.15 001243269.1_49824001_2 - 4.2e-238 789.6 22.7 5.4e-238 789.2 22.7 1.0 1 0 0 1 1 1 1 Calsequestrin Thioredoxin_6 PF13848.4 001243269.1_49824001_2 - 2.4e-25 89.4 10.2 5.9e-20 71.9 3.3 2.9 2 1 1 3 3 3 2 Thioredoxin-like domain WGG PF10273.7 001243269.1_49824001_2 - 0.93 10.1 5.0 1.3 9.6 1.1 2.5 2 1 0 2 2 2 0 Pre-rRNA-processing protein TSR2 7tm_1 PF00001.19 001194227.1_29622001_1 - 2.8e-48 164.3 15.8 3.6e-48 164.0 15.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001194227.1_29622001_1 - 1.7e-09 37.3 8.4 2.3e-09 36.9 8.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.7 001194227.1_29622001_1 - 1.4e-05 24.5 9.7 5e-05 22.6 9.7 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.7 001194227.1_29622001_1 - 2.8e-05 23.5 4.1 2.8e-05 23.5 4.1 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.7 001194227.1_29622001_1 - 0.07 12.3 5.6 0.035 13.3 3.2 1.7 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx DUF4632 PF15451.4 001194227.1_29622001_3 - 4.5 7.3 7.5 0.45 10.5 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4632) Lipocalin PF00061.21 001145222.2_49822001_2 - 2.9e-19 69.6 0.5 3.4e-19 69.4 0.5 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 001145222.2_49822001_2 - 0.0068 16.2 0.1 0.0081 16.0 0.1 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family PKI PF02827.14 001193428.1_29622001_3 - 1.5e-27 95.4 0.2 2.5e-27 94.7 0.2 1.3 1 0 0 1 1 1 1 cAMP-dependent protein kinase inhibitor PKI PF02827.14 001193422.1_29622001_1 - 4.5e-28 97.1 0.9 6.4e-28 96.6 0.9 1.2 1 0 0 1 1 1 1 cAMP-dependent protein kinase inhibitor Pam16 PF03656.11 001347979.1_39727001_2 - 1.1e-59 199.8 1.7 1.9e-59 199.1 1.7 1.4 1 0 0 1 1 1 1 Pam16 WD40_4 PF16300.3 001347979.1_39727001_2 - 9.4e-35 118.1 1.5 1.2e-17 63.3 0.3 2.5 2 0 0 2 2 2 2 Type of WD40 repeat WD40 PF00400.30 001347979.1_39727001_2 - 1.8e-32 110.7 3.9 5.6e-07 30.0 0.1 7.9 8 0 0 8 8 8 5 WD domain, G-beta repeat DUF1899 PF08953.9 001347979.1_39727001_2 - 1.3e-25 88.9 0.0 6e-12 45.1 0.0 2.7 3 0 0 3 3 3 2 Domain of unknown function (DUF1899) ANAPC4_WD40 PF12894.5 001347979.1_39727001_2 - 7.4e-15 54.9 0.0 0.00034 20.7 0.0 5.2 3 2 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 001347979.1_39727001_2 - 8.6e-07 28.1 0.0 0.016 14.1 0.0 3.6 4 1 0 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.10 001347979.1_39727001_2 - 0.099 12.5 0.3 6.3 6.7 0.0 3.0 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Marek_A PF02124.13 001347979.1_39727001_2 - 0.11 12.2 0.1 0.25 11.0 0.1 1.5 2 0 0 2 2 2 0 Marek's disease glycoprotein A Cytochrom_D1 PF02239.14 001347979.1_39727001_2 - 0.17 10.3 0.0 0.39 9.1 0.0 1.5 2 0 0 2 2 2 0 Cytochrome D1 heme domain PALB2_WD40 PF16756.3 001347979.1_39727001_2 - 0.18 10.6 0.0 0.33 9.7 0.0 1.4 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain WD40_4 PF16300.3 001347980.1_39727001_2 - 1.1e-34 117.9 1.5 1.3e-17 63.2 0.3 2.5 2 0 0 2 2 2 2 Type of WD40 repeat WD40 PF00400.30 001347980.1_39727001_2 - 3.9e-32 109.7 4.8 5.9e-07 30.0 0.1 8.1 8 0 0 8 8 8 5 WD domain, G-beta repeat DUF1899 PF08953.9 001347980.1_39727001_2 - 1.5e-25 88.7 0.0 6.4e-12 45.0 0.0 2.7 3 0 0 3 3 3 2 Domain of unknown function (DUF1899) ANAPC4_WD40 PF12894.5 001347980.1_39727001_2 - 1.1e-14 54.4 0.0 0.00036 20.6 0.0 5.1 3 2 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 001347980.1_39727001_2 - 1.1e-06 27.7 0.0 0.017 14.0 0.0 3.6 3 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Marek_A PF02124.13 001347980.1_39727001_2 - 0.11 12.1 0.1 0.27 10.9 0.1 1.6 1 0 0 1 1 1 0 Marek's disease glycoprotein A PD40 PF07676.10 001347980.1_39727001_2 - 0.11 12.3 0.3 6.7 6.6 0.0 3.0 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.14 001347980.1_39727001_2 - 0.19 10.1 0.0 0.41 9.0 0.0 1.5 2 0 0 2 2 2 0 Cytochrome D1 heme domain PALB2_WD40 PF16756.3 001347980.1_39727001_2 - 0.19 10.4 0.0 0.35 9.6 0.0 1.3 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain WD40_4 PF16300.3 001347976.1_08027001_3 - 2e-34 117.1 2.0 9.8e-17 60.4 0.2 2.5 2 0 0 2 2 2 2 Type of WD40 repeat WD40 PF00400.30 001347976.1_08027001_3 - 1e-32 111.5 1.1 6.6e-08 33.0 0.2 7.7 7 0 0 7 7 7 5 WD domain, G-beta repeat DUF1899 PF08953.9 001347976.1_08027001_3 - 2.6e-24 84.7 0.0 6.7e-12 45.0 0.0 2.8 3 0 0 3 3 3 2 Domain of unknown function (DUF1899) ANAPC4_WD40 PF12894.5 001347976.1_08027001_3 - 1.2e-11 44.6 0.0 0.0022 18.1 0.0 4.6 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 001347976.1_08027001_3 - 9.9e-07 27.9 0.0 0.03 13.2 0.0 3.2 4 0 0 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Marek_A PF02124.13 001347976.1_08027001_3 - 0.051 13.3 0.1 0.099 12.3 0.1 1.4 1 0 0 1 1 1 0 Marek's disease glycoprotein A Pam16 PF03656.11 001347988.1_08022001_3 - 9.2e-59 196.9 1.8 1.1e-58 196.7 1.8 1.0 1 0 0 1 1 1 1 Pam16 Integrase_Zn PF02022.17 001347988.1_08022001_3 - 0.21 11.4 2.0 4.3 7.2 0.8 2.3 2 0 0 2 2 2 0 Integrase Zinc binding domain Ribosomal_S19 PF00203.19 001304888.1_01321001_2 - 1.3e-40 137.0 0.4 1.9e-40 136.5 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Prok_Ub PF14454.4 001304888.1_01321001_2 - 0.018 14.6 0.1 0.047 13.2 0.1 1.6 1 0 0 1 1 1 0 Prokaryotic Ubiquitin MAP65_ASE1 PF03999.10 001304888.1_01321001_2 - 0.024 13.2 0.8 0.028 13.0 0.8 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) LCAT PF02450.13 001304888.1_01321001_2 - 0.12 11.4 0.1 0.16 11.0 0.1 1.1 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase GST_N_3 PF13417.4 001348021.1_01323001_2 - 3.4e-12 46.5 0.0 6.3e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.18 001348021.1_01323001_2 - 3.7e-12 46.3 0.0 7.1e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 001348021.1_01323001_2 - 3.7e-06 26.9 0.0 7.2e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.4 001348021.1_01323001_2 - 8.6e-06 25.9 0.0 1.6e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.4 001348021.1_01323001_2 - 8.4e-05 22.6 0.0 0.0002 21.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 001348021.1_01323001_2 - 0.0016 18.2 0.3 0.0057 16.4 0.2 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.2 001348021.1_01323001_2 - 0.029 15.0 0.1 0.21 12.3 0.1 2.3 2 1 0 2 2 2 0 Glutathione S-transferase N-terminal domain Ribosomal_L3 PF00297.20 001280414.1_39723001_3 - 8.4e-194 643.5 10.6 9.7e-194 643.3 10.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 GST_N_3 PF13417.4 001348020.1_01323001_1 - 6.7e-12 45.5 0.1 1.3e-11 44.5 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.18 001348020.1_01323001_1 - 2.3e-11 43.7 0.0 5.2e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 001348020.1_01323001_1 - 4.8e-06 26.7 0.0 9e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.4 001348020.1_01323001_1 - 0.017 15.1 0.0 0.037 14.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 001348020.1_01323001_1 - 0.045 13.8 0.0 0.079 13.1 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain CD20 PF04103.13 001009388.2_22424001_2 - 1.2e-48 165.1 3.1 1.7e-48 164.5 3.1 1.2 1 0 0 1 1 1 1 CD20-like family 7tm_1 PF00001.19 001309046.1_22424001_1 - 5.2e-63 212.6 19.0 7.8e-63 212.1 19.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001309046.1_22424001_1 - 1.6e-17 63.6 18.9 2.1e-17 63.2 18.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 001309046.1_22424001_1 - 3e-08 33.2 18.3 2.4e-07 30.3 16.5 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.7 001309046.1_22424001_1 - 2.3e-07 30.3 17.8 2.3e-07 30.3 17.8 2.0 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx FtsK_4TM PF13491.4 001309046.1_22424001_1 - 0.011 15.4 1.5 0.011 15.4 1.5 2.0 1 1 1 2 2 2 0 4TM region of DNA translocase FtsK/SpoIIIE Interferon PF00143.17 001089309.1_22422001_1 - 5.7e-55 185.7 0.0 6.5e-55 185.6 0.0 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain GBP PF02263.17 001128473.1_49827001_2 - 1.4e-121 404.5 0.1 1.4e-121 404.5 0.1 3.1 3 0 0 3 3 3 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.12 001128473.1_49827001_2 - 2.5e-121 404.5 28.3 3.3e-121 404.1 28.3 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain RHD3 PF05879.10 001128473.1_49827001_2 - 0.00068 17.8 0.0 0.00068 17.8 0.0 2.2 2 0 0 2 2 2 1 Root hair defective 3 GTP-binding protein (RHD3) MMR_HSR1 PF01926.21 001128473.1_49827001_2 - 0.0042 17.0 0.0 0.014 15.4 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF2252 PF10009.7 001128473.1_49827001_2 - 9.6 5.0 16.8 1.4 7.7 0.2 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2252) MAGE PF01454.17 001123144.1_49822001_1 - 2.3e-20 73.1 0.0 1.2e-13 51.1 0.0 2.2 1 1 1 2 2 2 2 MAGE family Sec62 PF03839.14 001105305.1_49823001_1 - 2e-76 256.1 5.1 2e-76 256.1 5.1 2.4 1 1 1 2 2 2 1 Translocation protein Sec62 DEP PF00610.19 001105305.1_49823001_1 - 0.013 15.5 0.0 0.039 13.9 0.0 1.8 1 0 0 1 1 1 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Ctr PF04145.13 001105305.1_49823001_1 - 0.043 14.3 0.1 0.043 14.3 0.1 2.6 2 1 0 2 2 2 0 Ctr copper transporter family Dsh_C PF12316.6 001105305.1_49823001_1 - 3.4 7.9 16.3 4.7 7.5 0.8 2.3 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal EOS1 PF12326.6 001105305.1_49823001_1 - 3.8 7.3 4.5 3.3 7.5 0.2 2.5 2 0 0 2 2 2 0 N-glycosylation protein SNCAIP_SNCA_bd PF16700.3 001105053.1_49826001_1 - 1.6e-22 78.8 7.6 4.3e-22 77.4 7.6 1.8 1 0 0 1 1 1 1 Synphilin-1 alpha-Synuclein-binding domain Ank_2 PF12796.5 001105053.1_49826001_1 - 2e-16 60.2 1.1 6.3e-07 29.8 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001105053.1_49826001_1 - 2e-14 53.6 1.3 3.7e-05 24.1 0.1 4.4 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.4 001105053.1_49826001_1 - 1.5e-13 50.5 0.8 0.0012 19.1 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 001105053.1_49826001_1 - 5.8e-07 29.6 2.1 0.0071 16.6 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.4 001105053.1_49826001_1 - 6.3e-05 22.9 0.4 1.3 9.7 0.1 4.0 4 0 0 4 4 4 2 Ankyrin repeat Lebercilin PF15619.4 001168996.1_40425001_1 - 2.6e-66 222.8 44.2 2.6e-66 222.8 44.2 2.4 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease DUF1515 PF07439.9 001168996.1_40425001_1 - 9.5 6.1 11.3 2 8.3 2.8 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF1515) zf-BED PF02892.13 001168996.1_40425001_2 - 0.015 15.2 6.4 0.13 12.2 1.4 2.5 2 0 0 2 2 2 0 BED zinc finger Troponin PF00992.18 001172866.1_09922001_1 - 1.1e-35 122.8 51.6 3.4e-31 108.2 38.2 3.1 2 2 1 3 3 3 2 Troponin CSRNP_N PF16019.3 001172866.1_09922001_2 - 0.067 13.0 4.1 0.11 12.3 4.1 1.3 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Bystin PF05291.9 001168752.1_40423001_1 - 3.5e-141 469.5 0.1 4.5e-141 469.1 0.1 1.1 1 0 0 1 1 1 1 Bystin Beta-lactamase PF00144.22 001168752.1_40423001_1 - 0.0067 15.6 0.0 0.01 15.0 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase MEA1 PF06910.9 001168752.1_40423001_1 - 0.022 14.3 0.4 0.032 13.7 0.4 1.3 1 0 0 1 1 1 0 Male enhanced antigen 1 (MEA1) PKD PF00801.18 001246202.1_49829001_1 - 3e-196 635.6 86.3 1.6e-22 79.0 0.8 17.8 18 0 0 18 18 18 16 PKD domain PKD_channel PF08016.10 001246202.1_49829001_1 - 1.5e-110 369.7 0.0 2.1e-110 369.2 0.0 1.2 1 0 0 1 1 1 1 Polycystin cation channel REJ PF02010.13 001246202.1_49829001_1 - 9.7e-108 360.7 0.0 2.3e-107 359.4 0.0 1.7 1 0 0 1 1 1 1 REJ domain PLAT PF01477.21 001246202.1_49829001_1 - 2.4e-20 73.1 0.0 5.5e-20 72.0 0.0 1.6 1 0 0 1 1 1 1 PLAT/LH2 domain LRR_8 PF13855.4 001246202.1_49829001_1 - 1.8e-10 40.3 5.4 4e-10 39.2 5.4 1.6 1 0 0 1 1 1 1 Leucine rich repeat Y_Y_Y PF07495.11 001246202.1_49829001_1 - 4.7e-09 35.9 0.0 0.014 15.2 0.0 6.0 8 0 0 8 8 8 2 Y_Y_Y domain Lectin_C PF00059.19 001246202.1_49829001_1 - 1.2e-07 32.3 0.0 2.7e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 Lectin C-type domain WSC PF01822.17 001246202.1_49829001_1 - 3.1e-07 30.4 2.7 7.7e-07 29.1 2.7 1.7 1 0 0 1 1 1 1 WSC domain PKD_3 PF16820.3 001246202.1_49829001_1 - 6e-05 22.6 3.1 2.6 7.7 0.0 6.2 8 0 0 8 8 8 1 PKD-like domain LRRNT PF01462.16 001246202.1_49829001_1 - 0.00061 19.2 6.7 0.00061 19.2 6.7 2.6 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_4 PF12799.5 001246202.1_49829001_1 - 0.00062 19.9 8.8 0.0022 18.2 1.1 2.4 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRRCT PF01463.22 001246202.1_49829001_1 - 0.00088 19.5 0.4 0.00088 19.5 0.4 3.3 3 0 0 3 3 1 1 Leucine rich repeat C-terminal domain GPS PF01825.19 001246202.1_49829001_1 - 0.0078 16.7 0.0 0.023 15.2 0.0 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif LRR_1 PF00560.31 001246202.1_49829001_1 - 1.3 9.6 3.1 86 4.1 0.0 3.6 3 0 0 3 3 2 0 Leucine Rich Repeat CarboxypepD_reg PF13620.4 001246202.1_49829001_1 - 2.7 8.2 9.3 43 4.4 0.1 5.3 5 0 0 5 5 5 0 Carboxypeptidase regulatory-like domain EF-hand_6 PF13405.4 214374.2_49822001_3 - 5.5e-09 35.1 0.8 0.0012 18.4 0.0 3.5 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.30 214374.2_49822001_3 - 2.4e-08 32.8 0.7 0.038 13.4 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.4 214374.2_49822001_3 - 4.2e-05 23.8 0.0 0.0081 16.5 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.4 214374.2_49822001_3 - 0.00076 19.6 0.0 0.17 12.1 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.4 214374.2_49822001_3 - 0.0096 15.5 0.3 1.9 8.2 0.1 2.6 1 1 1 2 2 2 2 EF-hand domain pair TIR PF01582.18 001285605.1_09025001_1 - 8.9e-26 90.6 0.3 2.4e-25 89.2 0.3 1.7 2 0 0 2 2 2 1 TIR domain LRR_8 PF13855.4 001285605.1_09025001_1 - 7e-21 73.6 38.8 1.7e-06 27.5 2.2 7.3 3 3 4 7 7 7 6 Leucine rich repeat LRR_4 PF12799.5 001285605.1_09025001_1 - 2e-17 62.8 46.0 2.3e-05 24.5 0.3 8.5 7 1 2 9 9 9 5 Leucine Rich repeats (2 copies) TIR_2 PF13676.4 001285605.1_09025001_1 - 3.2e-12 46.5 0.0 6.1e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 TIR domain LRR_9 PF14580.4 001285605.1_09025001_1 - 6.5e-06 25.6 9.2 0.2 11.0 0.9 3.7 3 0 0 3 3 3 3 Leucine-rich repeat LRRCT PF01463.22 001285605.1_09025001_1 - 0.00016 21.9 0.1 0.0013 19.0 0.0 2.7 2 0 0 2 2 2 1 Leucine rich repeat C-terminal domain LRR_6 PF13516.4 001285605.1_09025001_1 - 0.00095 18.9 35.1 0.32 11.0 0.3 10.6 11 0 0 11 11 11 2 Leucine Rich repeat DUF1863 PF08937.9 001285605.1_09025001_1 - 0.071 13.3 0.1 0.27 11.4 0.1 1.9 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) LRR_1 PF00560.31 001285605.1_09025001_1 - 0.13 12.7 42.5 1.8 9.2 0.4 11.0 10 2 1 11 11 11 0 Leucine Rich Repeat NAD_binding_1 PF00175.19 001287711.1_29524001_1 - 6.7e-36 123.1 0.0 9.8e-36 122.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.22 001287711.1_29524001_1 - 1.3e-35 121.5 0.0 1.9e-35 121.0 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.10 001287711.1_29524001_1 - 7.1e-05 22.8 0.0 0.00032 20.7 0.0 1.9 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.9 001287711.1_29524001_1 - 0.16 12.1 0.0 0.41 10.7 0.0 1.7 2 0 0 2 2 2 0 Siderophore-interacting FAD-binding domain YIF1 PF03878.13 001245006.1_49823001_2 - 1.2e-85 286.7 2.7 1.5e-85 286.4 2.7 1.0 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.15 001245006.1_49823001_2 - 1.5e-08 34.4 12.0 2.4e-08 33.8 12.0 1.3 1 0 0 1 1 1 1 Yip1 domain ECF_trnsprt PF12822.5 001245006.1_49823001_2 - 0.017 15.0 6.0 0.037 14.0 6.0 1.6 1 0 0 1 1 1 0 ECF transporter, substrate-specific component TMEM132D_C PF15706.3 001245006.1_49823001_2 - 0.048 13.3 0.2 0.095 12.4 0.2 1.4 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term MHC_II_beta PF00969.17 001113695.1_49823001_1 - 4.3e-35 119.6 0.5 6.5e-35 119.0 0.5 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001113695.1_49823001_1 - 2.8e-25 88.5 0.2 6.5e-25 87.3 0.1 1.7 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001113695.1_49823001_1 - 0.00091 19.7 0.1 0.0022 18.4 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin domain MHC_I PF00129.16 001113695.1_49823001_1 - 0.032 13.7 0.1 0.052 13.0 0.1 1.2 1 0 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 zf-C3Hc3H PF13891.4 001287027.1_09025001_3 - 3.1e-30 104.2 23.1 3e-16 59.4 4.9 2.6 2 0 0 2 2 2 2 Potential DNA-binding domain Inhibitor_Mig-6 PF11555.6 001287027.1_09025001_3 - 0.24 11.4 3.5 11 6.1 0.1 2.8 2 0 0 2 2 2 0 EGFR receptor inhibitor Mig-6 WRC PF08879.8 001287027.1_09025001_3 - 0.85 9.3 0.0 0.85 9.3 0.0 3.9 4 0 0 4 4 4 0 WRC zf-TRM13_CCCH PF11722.6 001287027.1_09025001_3 - 4.2 7.1 15.1 0.73 9.5 0.2 3.5 4 0 0 4 4 4 0 CCCH zinc finger in TRM13 protein Lipase PF00151.17 001195638.1_37927001_3 - 1.2e-102 343.5 0.0 2.1e-102 342.7 0.0 1.3 1 0 0 1 1 1 1 Lipase PLAT PF01477.21 001195638.1_37927001_3 - 1.1e-22 80.6 0.1 1.9e-22 79.9 0.1 1.4 1 0 0 1 1 1 1 PLAT/LH2 domain Abhydrolase_1 PF00561.18 001195638.1_37927001_3 - 0.015 14.8 0.3 0.024 14.2 0.3 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Sec23_trunk PF04811.13 001280394.1_39726001_2 - 8.3e-80 267.7 0.0 1.2e-79 267.3 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.10 001280394.1_39726001_2 - 6.5e-32 110.0 0.0 1.5e-31 108.9 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.13 001280394.1_39726001_2 - 1.2e-25 89.2 0.1 3.1e-25 87.8 0.1 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Gelsolin PF00626.20 001280394.1_39726001_2 - 9.2e-17 60.6 0.0 2.3e-16 59.3 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat zf-Sec23_Sec24 PF04810.13 001280394.1_39726001_2 - 3.2e-15 55.8 5.9 6.5e-15 54.8 5.9 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger NRN1 PF15056.4 001285189.1_29524001_3 - 1.3e-37 127.6 1.1 2e-37 127.0 1.1 1.2 1 0 0 1 1 1 1 Neuritin protein family Transglut_C PF00927.20 001173102.1_09928001_3 - 3.7e-48 161.9 0.0 2.2e-25 88.7 0.0 2.4 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_N PF00868.18 001173102.1_09928001_3 - 1.2e-30 106.2 0.0 1.9e-30 105.5 0.0 1.3 1 0 0 1 1 1 1 Transglutaminase family Transglut_core PF01841.17 001173102.1_09928001_3 - 2.7e-17 63.1 0.3 4.8e-17 62.3 0.3 1.3 1 0 0 1 1 1 1 Transglutaminase-like superfamily Troponin PF00992.18 001172863.1_09922001_1 - 1.4e-35 122.4 51.6 3.8e-31 108.0 38.2 3.2 2 2 1 3 3 3 2 Troponin CSRNP_N PF16019.3 001172863.1_09922001_2 - 0.055 13.2 4.1 0.093 12.5 4.1 1.3 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus DUF4816 PF16086.3 001172863.1_09922001_2 - 0.078 12.8 4.9 0.22 11.4 4.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4816) WD40 PF00400.30 001280268.1_39724001_2 - 9.9e-19 67.2 25.0 0.0013 19.4 0.1 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001280268.1_39724001_2 - 1.8e-06 28.0 4.5 0.022 14.9 0.1 3.8 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Troponin PF00992.18 001172867.1_09922001_1 - 7.2e-36 123.3 51.6 2.8e-31 108.5 38.1 2.8 2 1 1 3 3 3 2 Troponin DUF4816 PF16086.3 001172867.1_09922001_2 - 0.17 11.8 9.3 0.37 10.7 9.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4816) XPC-binding PF09280.9 001261788.1_29624001_3 - 3.2e-26 90.7 20.6 5.5e-26 90.0 20.6 1.4 1 0 0 1 1 1 1 XPC-binding domain UBA PF00627.29 001261788.1_29624001_3 - 1.2e-25 88.9 2.5 1.5e-13 50.2 0.3 2.5 2 0 0 2 2 2 2 UBA/TS-N domain ubiquitin PF00240.21 001261788.1_29624001_3 - 4.2e-21 74.3 0.7 7e-21 73.6 0.7 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 001261788.1_29624001_3 - 5.3e-07 29.2 2.4 8.5e-07 28.6 2.4 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.4 001261788.1_29624001_3 - 1.6e-05 24.8 0.2 3.1e-05 23.9 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.8 001261788.1_29624001_3 - 0.001 18.7 0.0 0.016 14.9 0.0 2.2 2 0 0 2 2 2 1 Fungal ubiquitin-associated domain DUF2407 PF10302.7 001261788.1_29624001_3 - 0.023 15.1 0.0 0.05 14.0 0.0 1.5 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain UBA_2 PF08587.9 001261788.1_29624001_3 - 0.12 12.4 0.0 0.28 11.2 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) DUF1296 PF06972.9 001261788.1_29624001_3 - 0.15 12.1 0.2 4.8 7.3 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1296) Ubiquitin_2 PF14560.4 001261788.1_29624001_3 - 0.16 12.3 0.6 0.67 10.3 0.6 2.0 1 1 0 1 1 1 0 Ubiquitin-like domain Troponin PF00992.18 001172868.1_09922001_1 - 6.6e-36 123.4 51.6 2.7e-31 108.5 38.1 2.7 2 1 1 3 3 3 2 Troponin DUF4816 PF16086.3 001172868.1_09922001_2 - 0.54 10.1 5.0 1.2 9.0 5.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4816) Ferritin PF00210.22 001285609.1_09022001_1 - 2e-38 131.4 4.0 2.6e-38 131.0 4.0 1.1 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.15 001285609.1_09022001_1 - 0.012 15.9 0.8 0.015 15.6 0.8 1.3 1 1 0 1 1 1 0 Rubrerythrin Troponin PF00992.18 001172865.1_09922001_1 - 1.2e-35 122.6 51.6 3.5e-31 108.1 38.2 3.2 2 1 1 3 3 3 2 Troponin CSRNP_N PF16019.3 001172865.1_09922001_2 - 0.074 12.8 4.1 0.12 12.2 4.1 1.3 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus DUF4816 PF16086.3 001172865.1_09922001_2 - 0.17 11.7 6.0 0.49 10.3 6.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4816) RRM_1 PF00076.20 001173457.1_32323001_2 - 1.1e-22 79.5 0.1 1.6e-22 78.9 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM1CTR PF08081.9 001173457.1_32323001_2 - 2.8e-21 75.2 15.5 2.8e-21 75.2 15.5 8.7 4 2 3 7 7 7 1 RBM1CTR (NUC064) family RRM_7 PF16367.3 001173457.1_32323001_2 - 0.0056 16.6 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.4 001173457.1_32323001_2 - 0.025 14.0 0.0 0.045 13.2 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001173457.1_32323001_2 - 0.092 12.5 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif PHM7_cyt PF14703.4 001173457.1_32323001_2 - 0.15 12.2 0.0 0.25 11.4 0.0 1.3 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter Treacle PF03546.12 001039952.1_29629001_1 - 1.4e-246 819.4 255.0 2.4e-173 577.7 124.4 9.6 1 1 7 9 9 9 5 Treacher Collins syndrome protein Treacle Gal-3-0_sulfotr PF06990.9 001039952.1_29629001_1 - 0.03 13.1 0.1 0.053 12.3 0.1 1.3 1 0 0 1 1 1 0 Galactose-3-O-sulfotransferase XPC-binding PF09280.9 001244709.1_39724001_1 - 3.1e-26 90.7 20.6 5.1e-26 90.0 20.6 1.4 1 0 0 1 1 1 1 XPC-binding domain UBA PF00627.29 001244709.1_39724001_1 - 1.1e-25 88.9 2.5 1.4e-13 50.3 0.3 2.5 2 0 0 2 2 2 2 UBA/TS-N domain ubiquitin PF00240.21 001244709.1_39724001_1 - 1.1e-13 50.5 0.1 2.1e-13 49.6 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.4 001244709.1_39724001_1 - 0.00026 20.9 0.1 0.00053 19.9 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.8 001244709.1_39724001_1 - 0.0009 18.9 0.0 0.015 14.9 0.0 2.2 2 0 0 2 2 2 1 Fungal ubiquitin-associated domain DUF2407 PF10302.7 001244709.1_39724001_1 - 0.077 13.4 0.0 0.18 12.2 0.0 1.6 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain UBA_2 PF08587.9 001244709.1_39724001_1 - 0.12 12.4 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) Interferon PF00143.17 001285756.1_09022001_1 - 6.4e-65 218.1 0.7 7.2e-65 217.9 0.7 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain HLH PF00010.24 001261031.1_29627001_3 - 2.1e-11 43.5 1.0 8.9e-10 38.3 1.2 3.0 3 0 0 3 3 3 1 Helix-loop-helix DNA-binding domain KASH_CCD PF14662.4 001261031.1_29627001_3 - 0.027 14.2 4.7 0.056 13.2 4.7 1.4 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH BRE1 PF08647.9 001261031.1_29627001_3 - 1.4 9.0 6.1 0.25 11.3 2.4 1.7 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase CCDC106 PF15794.3 001261031.1_29627001_3 - 3.2 7.3 11.1 0.089 12.4 3.2 2.0 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 Sec63 PF02889.14 001171321.1_37925001_1 - 3.6e-19 68.8 6.2 3.4e-09 36.1 0.1 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DnaJ PF00226.29 001171321.1_37925001_1 - 3.7e-17 62.1 0.0 9.6e-17 60.7 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain SAGA-Tad1 PF12767.5 001171321.1_37925001_1 - 0.67 9.5 9.7 1.5 8.4 9.7 1.5 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit WD40 PF00400.30 001280218.1_39724001_2 - 1.4e-11 44.6 9.3 0.0064 17.2 0.1 6.8 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001280218.1_39724001_2 - 0.00014 22.0 0.1 0.037 14.2 0.1 3.2 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Jun PF03957.11 001198947.1_37923001_1 - 2.8e-99 331.6 10.1 3.9e-99 331.1 10.1 1.2 1 0 0 1 1 1 1 Jun-like transcription factor bZIP_1 PF00170.19 001198947.1_37923001_1 - 8.5e-18 64.1 17.8 2.1e-17 62.8 17.8 1.7 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 001198947.1_37923001_1 - 2.1e-09 37.2 14.4 7.3e-09 35.4 14.4 1.9 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 001198947.1_37923001_1 - 1.8e-08 34.6 9.3 1.8e-08 34.6 9.3 1.8 2 0 0 2 2 1 1 bZIP Maf transcription factor ZapB PF06005.10 001198947.1_37923001_1 - 0.0014 18.9 7.5 0.0053 17.0 4.9 2.4 2 0 0 2 2 2 1 Cell division protein ZapB Jnk-SapK_ap_N PF09744.7 001198947.1_37923001_1 - 0.024 14.7 7.1 0.046 13.8 7.1 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 FlaC_arch PF05377.9 001198947.1_37923001_1 - 0.029 14.6 1.6 0.064 13.5 1.6 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Mnd1 PF03962.13 001198947.1_37923001_1 - 0.064 13.0 3.1 0.098 12.4 3.1 1.2 1 0 0 1 1 1 0 Mnd1 family TSC22 PF01166.16 001198947.1_37923001_1 - 0.066 13.4 1.0 0.21 11.8 1.0 1.9 1 0 0 1 1 1 0 TSC-22/dip/bun family LMBR1 PF04791.14 001198947.1_37923001_1 - 1.4 7.6 2.7 1.6 7.4 2.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF1664 PF07889.10 001198947.1_37923001_1 - 1.6 8.6 5.0 2.7 7.9 5.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DivIC PF04977.13 001198947.1_37923001_1 - 3.5 7.3 8.3 1.8 8.2 4.7 2.3 1 1 1 2 2 2 0 Septum formation initiator Barttin PF15462.4 001082221.1_37922001_1 - 1.1e-115 384.9 0.1 1.4e-115 384.5 0.1 1.1 1 0 0 1 1 1 1 Bartter syndrome, infantile, with sensorineural deafness (Barttin) MHC_I PF00129.16 001283228.1_29523001_3 - 3.2e-95 316.6 1.1 4.5e-95 316.1 1.1 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001283228.1_29523001_3 - 1.3e-16 60.7 0.0 2.9e-16 59.6 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001283228.1_29523001_3 - 4.1e-16 58.5 9.6 7.1e-16 57.7 9.6 1.4 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 001283228.1_29523001_3 - 1.8e-05 25.1 0.8 0.084 13.4 0.0 3.0 1 1 1 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001283228.1_29523001_3 - 0.0012 18.8 0.1 0.0026 17.7 0.1 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001283228.1_29523001_3 - 0.025 14.6 0.0 0.074 13.1 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin domain PI-PLC-X PF00388.17 001281643.1_31324001_1 - 1.2e-60 203.1 0.0 2.4e-60 202.2 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.17 001281643.1_31324001_1 - 4.4e-39 133.3 0.0 9.1e-39 132.3 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.9 001281643.1_31324001_1 - 1.2e-20 73.7 4.8 1.4e-20 73.4 1.1 2.8 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.28 001281643.1_31324001_1 - 7.8e-14 51.7 0.0 1.6e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 C2 domain EF-hand_7 PF13499.4 001281643.1_31324001_1 - 7.7e-06 26.2 3.8 0.00076 19.8 1.1 3.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.4 001281643.1_31324001_1 - 7.2e-05 22.3 0.1 0.019 14.6 0.0 2.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.30 001281643.1_31324001_1 - 0.00026 20.2 0.1 0.0029 16.9 0.0 2.8 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 001281643.1_31324001_1 - 0.00038 20.0 0.3 0.011 15.5 0.0 3.4 5 0 0 5 5 5 1 EF-hand domain S_100 PF01023.17 001281643.1_31324001_1 - 0.79 9.4 4.8 0.3 10.7 0.7 2.4 2 0 0 2 2 2 0 S-100/ICaBP type calcium binding domain Trypsin PF00089.24 001009136.1_39722001_1 - 8.6e-35 120.4 0.0 1e-34 120.1 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001009136.1_39722001_1 - 1.7e-06 28.8 0.0 2.5e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001009136.1_39722001_1 - 0.0008 19.6 0.1 0.0052 17.0 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1986) COesterase PF00135.26 001128088.2_29625001_1 - 5.7e-173 576.4 0.0 6.8e-173 576.1 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family AChE_tetra PF08674.8 001128088.2_29625001_1 - 2.7e-20 71.6 9.4 4.6e-20 70.9 9.4 1.4 1 0 0 1 1 1 1 Acetylcholinesterase tetramerisation domain Abhydrolase_3 PF07859.11 001128088.2_29625001_1 - 1.4e-05 24.9 0.4 3.9e-05 23.5 0.4 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold MHC_I PF00129.16 001319468.1_29523001_1 - 1.6e-93 311.1 0.9 2.2e-93 310.6 0.9 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001319468.1_29523001_1 - 2.4e-16 59.9 0.0 4.5e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001319468.1_29523001_1 - 2.8e-14 52.6 12.0 5e-14 51.8 12.0 1.4 1 0 0 1 1 1 1 MHC_I C-terminus C2-set_2 PF08205.10 001319468.1_29523001_1 - 0.00061 19.7 0.1 0.0014 18.6 0.1 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001319468.1_29523001_1 - 0.076 13.1 0.1 0.24 11.5 0.0 1.8 2 0 0 2 2 2 0 Immunoglobulin domain Clat_adaptor_s PF01217.18 001285734.1_09023001_2 - 1.3e-44 151.4 0.8 1.9e-44 150.9 0.8 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain FAM176 PF14851.4 001109243.1_45724001_2 - 1.3e-57 193.4 0.3 1.6e-57 193.1 0.3 1.2 1 0 0 1 1 1 1 FAM176 family Peptidase_M24 PF00557.22 001280208.1_39724001_2 - 6.8e-56 189.1 0.0 8.9e-56 188.7 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.14 001280208.1_39724001_2 - 3e-37 126.9 0.0 5.4e-37 126.1 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain LRR_8 PF13855.4 001285757.1_09027001_2 - 3.9e-74 244.2 98.0 5.1e-09 35.6 8.3 15.0 10 5 5 15 15 15 15 Leucine rich repeat LRR_4 PF12799.5 001285757.1_09027001_2 - 2e-40 135.8 98.6 1.9e-05 24.7 0.8 15.5 6 4 13 19 19 19 18 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001285757.1_09027001_2 - 6e-21 71.5 74.2 0.24 11.9 0.1 22.1 21 2 0 21 21 21 8 Leucine Rich Repeat TIR PF01582.18 001285757.1_09027001_2 - 1.4e-13 50.9 1.0 2.4e-13 50.1 1.0 1.3 1 0 0 1 1 1 1 TIR domain LRR_5 PF13306.4 001285757.1_09027001_2 - 2.2e-11 43.7 21.3 0.049 13.5 2.4 8.1 3 2 4 8 8 8 4 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001285757.1_09027001_2 - 2.9e-07 30.0 34.2 0.035 13.5 0.2 8.2 4 3 5 9 9 9 5 Leucine-rich repeat TIR_2 PF13676.4 001285757.1_09027001_2 - 3.5e-05 23.9 0.1 7e-05 23.0 0.1 1.5 1 0 0 1 1 1 1 TIR domain LRR_6 PF13516.4 001285757.1_09027001_2 - 5.4 7.2 87.3 6.1 7.0 1.8 20.1 23 0 0 23 23 23 0 Leucine Rich repeat FNIP PF05725.10 001285757.1_09027001_2 - 8.1 6.6 36.9 3.9 7.6 2.4 7.5 6 1 1 7 7 7 0 FNIP Repeat Collagen PF01391.16 001105289.1_49829001_2 - 3.2e-165 535.9 701.4 3.7e-09 36.1 35.2 22.0 2 2 11 13 13 13 9 Collagen triple helix repeat (20 copies) COLFI PF01410.16 001105289.1_49829001_2 - 2.1e-105 351.1 0.1 2.7e-105 350.7 0.1 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain VWC PF00093.16 001105289.1_49829001_2 - 4.6e-13 49.1 14.5 7.5e-13 48.5 14.5 1.3 1 0 0 1 1 1 1 von Willebrand factor type C domain TILa PF12714.5 001105289.1_49829001_2 - 0.0013 18.5 6.4 0.003 17.4 6.4 1.5 1 0 0 1 1 1 1 TILa domain Amnionless PF14828.4 001105289.1_49829001_2 - 0.061 12.0 12.0 0.087 11.5 12.0 1.1 1 0 0 1 1 1 0 Amnionless Troponin PF00992.18 001172864.1_09922001_1 - 1.3e-35 122.5 51.6 3.7e-31 108.1 38.2 3.1 2 2 1 3 3 3 2 Troponin Amelogenin PF02948.13 001285616.1_09022001_1 - 2.7e-67 226.6 77.7 2.9e-53 180.9 55.4 2.5 2 1 1 3 3 3 2 Amelogenin BAR PF03114.16 001329079.1_37923001_1 - 3.4e-73 246.1 10.4 4.1e-73 245.8 10.4 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.26 001329079.1_37923001_1 - 8.1e-15 54.0 0.1 2.1e-14 52.7 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 001329079.1_37923001_1 - 1.9e-14 52.9 0.0 4.3e-14 51.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 001329079.1_37923001_1 - 6.3e-14 51.4 0.2 1.5e-13 50.2 0.1 1.7 2 0 0 2 2 2 1 Variant SH3 domain BAR_2 PF10455.7 001329079.1_37923001_1 - 7.8e-10 38.2 5.4 1.9e-08 33.6 2.8 2.1 2 0 0 2 2 2 2 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_3 PF16746.3 001329079.1_37923001_1 - 0.00012 21.7 6.8 0.00076 19.1 2.4 2.9 1 1 1 2 2 2 1 BAR domain of APPL family DNA_pol_B_2 PF03175.11 001329079.1_37923001_1 - 0.055 12.2 0.6 0.08 11.6 0.6 1.1 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral Latarcin PF10279.7 001329079.1_37923001_1 - 0.058 13.7 0.6 0.88 9.9 0.0 3.1 2 2 0 2 2 2 0 Latarcin precursor Glyco_hydro_30 PF02055.14 001005730.1_49824001_3 - 5.1e-190 630.7 0.1 6.1e-190 630.4 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C PF17189.2 001005730.1_49824001_3 - 1.1e-15 57.4 0.0 2.1e-15 56.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Paralemmin PF03285.13 001204170.2_39729001_3 - 1.1e-107 360.2 16.8 2e-107 359.3 16.8 1.4 1 0 0 1 1 1 1 Paralemmin CALCOCO1 PF07888.9 001204170.2_39729001_3 - 0.19 10.1 17.4 0.29 9.5 17.4 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF4472 PF14739.4 001204170.2_39729001_3 - 8.4 7.1 20.2 9.9 6.8 9.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) FlaC_arch PF05377.9 001204170.2_39729001_3 - 8.4 6.7 8.1 6.6 7.1 5.8 2.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Ig_3 PF13927.4 001047125.1_29625001_1 - 3.3e-66 219.7 40.9 1.3e-11 44.8 0.3 7.5 7 0 0 7 7 7 7 Immunoglobulin domain Ig_2 PF13895.4 001047125.1_29625001_1 - 2e-65 217.0 39.0 2.3e-16 59.8 0.6 7.3 7 1 0 7 7 7 7 Immunoglobulin domain I-set PF07679.14 001047125.1_29625001_1 - 3.4e-48 161.5 8.4 1.1e-06 28.5 0.0 9.6 7 4 0 7 7 7 7 Immunoglobulin I-set domain ig PF00047.23 001047125.1_29625001_1 - 1.6e-46 156.2 28.4 5.4e-08 32.8 0.2 8.4 7 3 0 7 7 7 7 Immunoglobulin domain V-set PF07686.15 001047125.1_29625001_1 - 5.4e-27 94.0 34.6 1.2e-08 34.9 0.0 11.8 7 6 6 13 13 13 8 Immunoglobulin V-set domain Ig_4 PF16680.3 001047125.1_29625001_1 - 4.9e-15 55.5 6.4 0.18 12.0 0.1 6.5 6 0 0 6 6 6 5 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.3 001047125.1_29625001_1 - 2.5e-14 53.3 7.5 0.086 13.1 0.0 6.4 6 0 0 6 6 6 4 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Adeno_E3_CR1 PF02440.13 001047125.1_29625001_1 - 6.6e-09 35.3 6.3 2.2 8.0 0.1 6.9 7 0 0 7 7 7 3 Adenovirus E3 region protein CR1 BiPBP_C PF06832.10 001047125.1_29625001_1 - 3.6e-06 26.8 0.0 6.9 6.7 0.0 5.7 6 0 0 6 6 6 2 Penicillin-Binding Protein C-terminus Family Izumo-Ig PF16706.3 001047125.1_29625001_1 - 9.4e-06 25.5 0.0 4.5 7.3 0.0 6.3 7 0 0 7 7 7 1 Izumo-like Immunoglobulin domain C2-set PF05790.13 001047125.1_29625001_1 - 2.4e-05 24.3 1.9 5.3 7.2 0.0 6.3 7 0 0 7 7 7 1 Immunoglobulin C2-set domain Lep_receptor_Ig PF06328.9 001047125.1_29625001_1 - 0.00054 19.8 14.0 2.2 8.3 0.5 6.0 6 0 0 6 6 6 2 Ig-like C2-type domain CARDB PF07705.9 001047125.1_29625001_1 - 0.91 9.7 7.1 12 6.1 0.5 3.3 3 0 0 3 3 3 0 CARDB MtrF PF09472.8 001047125.1_29625001_1 - 1.1 8.6 3.6 2 7.8 3.6 1.4 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) zf-C3Hc3H PF13891.4 001287026.1_09025001_3 - 3.7e-30 104.0 23.1 3.2e-16 59.3 4.9 2.6 2 0 0 2 2 2 2 Potential DNA-binding domain Inhibitor_Mig-6 PF11555.6 001287026.1_09025001_3 - 0.27 11.2 3.6 12 6.0 0.1 2.9 2 0 0 2 2 2 0 EGFR receptor inhibitor Mig-6 WRC PF08879.8 001287026.1_09025001_3 - 0.9 9.2 0.0 0.9 9.2 0.0 3.9 4 0 0 4 4 4 0 WRC zf-TRM13_CCCH PF11722.6 001287026.1_09025001_3 - 4.1 7.1 14.8 0.78 9.4 0.2 3.5 4 0 0 4 4 4 0 CCCH zinc finger in TRM13 protein FAM72 PF14976.4 144320.1_26224120_1 - 1.5e-47 161.2 3.7 2.3e-47 160.6 3.7 1.3 1 0 0 1 1 1 1 FAM72 protein RRM_1 PF00076.20 001246494.1_39725001_1 - 1.2e-30 105.0 0.0 1e-11 44.4 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF PF08080.10 001246494.1_39725001_1 - 1.5e-21 75.9 12.2 1.5e-21 75.9 12.2 1.9 2 0 0 2 2 2 1 RNPHF zinc finger Sod_Cu PF00080.18 001078688.1_49822001_1 - 4.4e-30 104.6 0.0 6.6e-30 104.0 0.0 1.2 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) AIF_C PF14721.4 001257878.1_29625001_3 - 7.5e-58 194.4 0.0 1.2e-57 193.7 0.0 1.3 1 0 0 1 1 1 1 Apoptosis-inducing factor, mitochondrion-associated, C-term Pyr_redox_2 PF07992.12 001257878.1_29625001_3 - 3.8e-41 141.1 0.0 6.1e-41 140.4 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.25 001257878.1_29625001_3 - 2.4e-15 56.7 0.1 7.1e-13 48.8 0.0 3.2 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase AIF-MLS PF14962.4 001257878.1_29625001_3 - 3.5e-11 43.3 0.1 3.5e-11 43.3 0.1 1.5 2 0 0 2 2 2 1 Mitochondria Localisation Sequence Pyr_redox_3 PF13738.4 001257878.1_29625001_3 - 1.2e-06 27.8 0.0 0.00011 21.5 0.0 2.7 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.12 001257878.1_29625001_3 - 0.00023 19.8 0.3 0.35 9.4 0.0 3.1 3 0 0 3 3 3 2 HI0933-like protein Amino_oxidase PF01593.22 001257878.1_29625001_3 - 0.00061 19.0 0.3 0.064 12.4 0.0 2.1 1 1 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.4 001257878.1_29625001_3 - 0.0017 18.3 1.0 2.9 7.7 0.0 4.1 3 1 1 4 4 4 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.4 001257878.1_29625001_3 - 0.055 13.6 1.3 8.1 6.6 0.0 2.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain PYNP_C PF07831.11 001257878.1_29625001_3 - 0.11 12.1 0.1 0.65 9.6 0.0 2.1 2 0 0 2 2 2 0 Pyrimidine nucleoside phosphorylase C-terminal domain HLH PF00010.24 001168780.1_40422001_1 - 7.7e-12 44.9 0.5 1.4e-11 44.0 0.5 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain CCDC106 PF15794.3 001168780.1_40422001_1 - 0.017 14.7 1.3 0.023 14.3 1.3 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 UBN_AB PF14075.4 001168780.1_40422001_1 - 0.082 12.5 0.1 0.12 12.0 0.1 1.1 1 0 0 1 1 1 0 Ubinuclein conserved middle domain DUF508 PF04370.10 001168780.1_40422001_1 - 0.45 10.1 3.3 0.94 9.1 3.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF508) SR-25 PF10500.7 001168780.1_40422001_1 - 1.1 8.7 15.1 2.1 7.8 15.1 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Sod_Fe_C PF02777.16 001280703.1_39523001_1 - 1.3e-37 127.9 0.0 2.1e-37 127.3 0.0 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.20 001280703.1_39523001_1 - 7.7e-33 112.7 2.7 1.1e-32 112.2 2.7 1.2 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain AIF_C PF14721.4 001297632.1_49824001_3 - 1.3e-57 193.6 0.0 2.2e-57 192.9 0.0 1.4 1 0 0 1 1 1 1 Apoptosis-inducing factor, mitochondrion-associated, C-term Pyr_redox_2 PF07992.12 001297632.1_49824001_3 - 1.7e-40 139.0 0.0 2.5e-40 138.4 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.25 001297632.1_49824001_3 - 4.9e-15 55.7 0.1 5.7e-13 49.1 0.1 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 001297632.1_49824001_3 - 5.1e-06 25.8 0.0 0.00017 20.8 0.0 2.6 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase AIF-MLS PF14962.4 001297632.1_49824001_3 - 0.00042 20.2 0.6 0.00067 19.6 0.0 1.6 2 0 0 2 2 2 1 Mitochondria Localisation Sequence Amino_oxidase PF01593.22 001297632.1_49824001_3 - 0.00047 19.4 0.3 0.011 14.9 0.1 2.1 1 1 0 2 2 2 1 Flavin containing amine oxidoreductase HI0933_like PF03486.12 001297632.1_49824001_3 - 0.00098 17.8 0.1 0.71 8.4 0.0 3.2 3 0 0 3 3 3 1 HI0933-like protein NAD_binding_9 PF13454.4 001297632.1_49824001_3 - 0.0038 17.1 0.9 3.3 7.6 0.0 4.0 3 1 1 4 4 4 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.4 001297632.1_49824001_3 - 0.045 13.9 1.3 7.1 6.8 0.0 2.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.5 001297632.1_49824001_3 - 0.095 11.9 0.1 0.44 9.7 0.1 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase DUF3918 PF13056.4 001297632.1_49824001_3 - 0.37 10.3 1.9 0.94 9.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3918) Ribosomal_L22 PF00237.17 001304910.1_01322001_1 - 1.4e-42 144.1 0.1 2.2e-42 143.5 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Methyltransf_3 PF01596.15 001282046.1_01324001_1 - 7.5e-13 48.0 0.0 1.1e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.4 001282046.1_01324001_1 - 1.6e-10 41.9 0.1 3.6e-10 40.7 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain LRR_8 PF13855.4 001282046.1_01324001_1 - 6e-07 29.0 1.6 6e-07 29.0 1.6 2.4 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.5 001282046.1_01324001_1 - 9.9e-06 25.7 4.1 0.00059 20.0 0.2 3.3 1 1 3 4 4 4 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001282046.1_01324001_1 - 0.00021 20.7 0.1 0.00071 19.0 0.1 1.9 1 1 0 1 1 1 1 Leucine-rich repeat PCMT PF01135.17 001282046.1_01324001_1 - 0.049 13.3 0.0 0.074 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) LRR_1 PF00560.31 001282046.1_01324001_1 - 3.7 8.3 5.6 1.1e+02 3.8 0.0 4.4 4 0 0 4 4 4 0 Leucine Rich Repeat S10_plectin PF03501.13 001304905.1_01322001_2 - 3.2e-50 168.0 0.2 4e-50 167.7 0.2 1.1 1 0 0 1 1 1 1 Plectin/S10 domain 40S_SA_C PF16122.3 001304869.1_01322001_3 - 1.6e-28 99.8 21.0 2.7e-28 99.0 21.0 1.4 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus Ribosomal_S2 PF00318.18 001304869.1_01322001_3 - 1.3e-25 89.8 0.0 1.3e-12 47.2 0.0 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 IL6 PF00489.15 001304922.1_01322001_1 - 2.8e-87 291.0 0.9 3.2e-87 290.8 0.9 1.0 1 0 0 1 1 1 1 Interleukin-6/G-CSF/MGF family GCSF PF16647.3 001304922.1_01322001_1 - 0.0013 18.5 0.2 0.0017 18.1 0.2 1.4 1 1 0 1 1 1 1 Granulocyte colony-stimulating factor IL23 PF16649.3 001304922.1_01322001_1 - 0.036 14.0 0.4 0.097 12.6 0.3 1.9 2 1 0 2 2 2 0 Interleukin 23 subunit alpha Ribosomal_S26e PF01283.17 001304932.1_01321001_3 - 6.4e-54 180.8 7.4 7.8e-54 180.6 7.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e Fer4_7 PF12838.5 001304932.1_01321001_3 - 0.012 16.1 0.7 0.16 12.5 0.4 2.1 2 0 0 2 2 2 0 4Fe-4S dicluster domain OS-D PF03392.11 001304932.1_01321001_3 - 0.084 12.8 0.2 0.17 11.9 0.2 1.4 1 0 0 1 1 1 0 Insect pheromone-binding family, A10/OS-D LSM PF01423.20 001304870.1_01321001_1 - 3.6e-20 71.3 0.2 4.9e-20 70.9 0.2 1.2 1 0 0 1 1 1 1 LSM domain vATP-synt_E PF01991.16 001304870.1_01321001_1 - 0.051 12.8 0.1 0.1 11.9 0.1 1.5 1 1 1 2 2 2 0 ATP synthase (E/31 kDa) subunit zf-Tim10_DDP PF02953.13 001304897.1_01321001_3 - 1.3e-23 82.3 0.7 1.8e-23 81.8 0.7 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger HSP20 PF00011.19 001304892.1_01322001_2 - 3.9e-25 87.8 0.0 5.7e-25 87.3 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family YabP PF07873.9 001304892.1_01322001_2 - 0.044 13.4 0.0 0.071 12.8 0.0 1.3 1 0 0 1 1 1 0 YabP family Ribosomal_S30 PF04758.12 001304904.1_01321001_1 - 5.7e-31 106.4 12.9 8.5e-31 105.8 12.9 1.3 1 0 0 1 1 1 1 Ribosomal protein S30 ubiquitin PF00240.21 001304904.1_01321001_1 - 4.4e-14 51.8 0.0 6.1e-14 51.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 001304904.1_01321001_1 - 0.0021 17.7 0.0 0.0038 16.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ribosomal_S17e PF00833.16 001304891.1_01321001_3 - 3.5e-70 233.5 0.6 4e-70 233.3 0.6 1.0 1 0 0 1 1 1 1 Ribosomal S17 Ribosomal_S9 PF00380.17 001304899.1_01321001_2 - 4.7e-34 117.4 0.3 5.3e-34 117.2 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Ribosomal_L21e PF01157.16 001304847.1_01322001_1 - 4.6e-52 173.8 8.8 4.6e-52 173.8 8.8 1.5 2 0 0 2 2 2 1 Ribosomal protein L21e CLP_protease PF00574.21 001304847.1_01322001_1 - 0.069 12.9 0.1 0.1 12.4 0.1 1.2 1 0 0 1 1 1 0 Clp protease Ribosomal_L23eN PF03939.11 001304856.1_01322001_2 - 1.6e-28 98.5 17.1 4e-28 97.3 17.1 1.7 1 0 0 1 1 1 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.18 001304856.1_01322001_2 - 3.2e-16 59.3 3.1 3.2e-16 59.3 3.1 2.6 2 2 0 2 2 2 1 Ribosomal protein L23 Ribosomal_L6 PF00347.21 001304856.1_01322001_2 - 0.057 14.0 1.4 0.075 13.6 0.1 1.8 2 0 0 2 2 2 0 Ribosomal protein L6 Ribosomal_L14e PF01929.15 001304887.1_01322001_2 - 3.4e-31 107.4 9.6 3.4e-31 107.4 9.6 1.8 2 0 0 2 2 2 1 Ribosomal protein L14 KOW PF00467.27 001304887.1_01322001_2 - 0.0012 18.5 0.3 0.0022 17.8 0.3 1.4 1 0 0 1 1 1 1 KOW motif Ribosomal_S10 PF00338.20 001304917.1_01321001_3 - 6e-31 106.4 0.3 7.4e-31 106.1 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Ribosomal_L5e PF17144.2 001304876.1_01322001_3 - 2.3e-94 313.7 0.7 2.3e-94 313.7 0.7 2.1 2 0 0 2 2 2 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.4 001304876.1_01322001_3 - 3.9e-40 136.5 12.8 3.9e-40 136.5 12.8 1.7 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Ribosomal_L22e PF01776.15 001304916.1_01321001_2 - 9.3e-54 180.3 0.9 1.2e-53 180.0 0.9 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family Leptin PF02024.13 001304929.1_01322001_1 - 4.9e-66 220.9 0.4 5.5e-66 220.7 0.4 1.0 1 0 0 1 1 1 1 Leptin Syntaxin_2 PF14523.4 001304929.1_01322001_1 - 0.14 12.4 1.8 4 7.7 0.4 2.4 1 1 0 2 2 2 0 Syntaxin-like protein Ribosomal_S3_C PF00189.18 001304928.1_01322001_2 - 2.2e-23 82.4 0.9 8.3e-23 80.6 0.2 2.1 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.15 001304928.1_01322001_2 - 1.7e-11 43.6 0.1 2.8e-11 42.9 0.1 1.4 1 0 0 1 1 1 1 KH domain Ribosomal_S7 PF00177.19 001304926.1_01322001_3 - 4.1e-37 127.0 1.0 5e-37 126.7 1.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Ribosomal_L11_N PF03946.12 001304867.1_01322001_2 - 4.2e-26 90.4 0.1 8.1e-26 89.4 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.17 001304867.1_01322001_2 - 3.2e-19 69.1 0.1 5e-19 68.5 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Dynactin_p22 PF07426.9 001304931.1_01322001_2 - 3e-58 196.2 0.7 3.6e-58 196.0 0.7 1.0 1 0 0 1 1 1 1 Dynactin subunit p22 DUF4011 PF13195.4 001304931.1_01322001_2 - 0.0038 17.1 0.6 0.0057 16.5 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4011) DUF948 PF06103.9 001304931.1_01322001_2 - 0.026 14.7 0.9 1.7 8.8 0.2 2.4 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Spidroin_MaSp PF11260.6 001304931.1_01322001_2 - 0.028 14.6 0.1 0.06 13.5 0.1 1.5 1 0 0 1 1 1 0 Major ampullate spidroin 1 and 2 Jnk-SapK_ap_N PF09744.7 001304931.1_01322001_2 - 0.033 14.3 3.2 0.021 14.9 1.6 1.5 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF4515 PF14988.4 001304931.1_01322001_2 - 0.036 13.8 4.5 0.073 12.8 4.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) DivIC PF04977.13 001304931.1_01322001_2 - 0.046 13.4 6.0 0.31 10.7 0.2 3.0 3 0 0 3 3 3 0 Septum formation initiator Lipocalin PF00061.21 001304862.1_01321001_2 - 4.6e-26 91.6 1.3 5.2e-26 91.4 1.3 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 001304862.1_01321001_2 - 1.7e-06 27.9 2.1 2.3e-06 27.4 2.1 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family HSP20 PF00011.19 001304862.1_01321001_2 - 0.054 13.5 0.4 0.24 11.5 0.4 1.9 1 1 0 1 1 1 0 Hsp20/alpha crystallin family Ribosomal_L7Ae PF01248.24 001304901.1_01321001_3 - 6.4e-26 89.8 0.1 7.9e-26 89.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Hydrolase_6 PF13344.4 001304901.1_01321001_3 - 0.062 13.3 0.0 0.091 12.7 0.0 1.3 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Ribosom_S12_S23 PF00164.23 001304935.1_01321001_3 - 6.3e-64 213.5 2.0 7.3e-64 213.3 2.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Ribosomal_L24e PF01246.18 001304866.1_01322001_1 - 5.6e-34 116.0 0.7 5.6e-34 116.0 0.7 1.8 2 0 0 2 2 2 1 Ribosomal protein L24e Ribosomal_60s PF00428.17 001304844.1_01321001_2 - 6.4e-25 87.4 1.6 9.2e-25 86.9 1.6 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein DEC-1_N PF04625.11 001304844.1_01321001_2 - 0.12 11.3 1.3 0.15 10.9 1.3 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Ribosomal_L34e PF01199.16 001304906.1_01321001_1 - 7.5e-43 144.6 7.7 9.7e-43 144.3 7.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L34e Redoxin PF08534.8 001304906.1_01321001_1 - 0.12 11.9 0.0 0.17 11.4 0.0 1.3 1 1 0 1 1 1 0 Redoxin IL1 PF00340.17 001304843.1_01322001_1 - 1.4e-31 108.5 0.9 2.6e-31 107.7 0.9 1.4 1 0 0 1 1 1 1 Interleukin-1 / 18 RNA_pol_Rpb8 PF03870.13 001304900.1_01322001_3 - 4.1e-54 182.4 0.2 4.6e-54 182.2 0.2 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.3 001304900.1_01322001_3 - 7.1e-05 22.7 0.0 0.057 13.3 0.0 2.1 2 0 0 2 2 2 2 DNA-directed RNA polymerase, subunit G Orn_Arg_deC_N PF02784.14 001293700.1_01324001_3 - 3e-68 229.8 0.0 3.6e-68 229.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001293700.1_01324001_3 - 1.1e-19 70.4 0.0 2.1e-19 69.5 0.0 1.5 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.22 001293700.1_01324001_3 - 0.00013 21.3 0.0 0.00029 20.2 0.0 1.5 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel SUI1 PF01253.20 001304841.1_01321001_3 - 6.3e-28 97.0 0.9 9.5e-28 96.4 0.9 1.3 1 0 0 1 1 1 1 Translation initiation factor SUI1 Ribosomal_L14 PF00238.17 001304923.1_01321001_2 - 8.1e-35 119.4 0.2 9.9e-35 119.1 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Gp_dh_C PF02800.18 001304846.1_01323001_1 - 1.8e-70 235.4 0.0 3.1e-70 234.7 0.0 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.22 001304846.1_01323001_1 - 1.9e-39 134.0 0.2 4.3e-39 132.8 0.2 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.18 001304846.1_01323001_1 - 0.063 13.3 0.1 0.19 11.7 0.0 1.8 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Ribosomal_60s PF00428.17 001304857.1_01321001_2 - 4.5e-26 91.1 7.5 6e-26 90.7 7.5 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein TFIID_30kDa PF03540.11 001304857.1_01321001_2 - 0.15 11.9 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID 23-30kDa subunit Ribosomal_S13 PF00416.20 001304861.1_01322001_1 - 6.1e-54 181.7 3.6 7.1e-54 181.5 3.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 PP28 PF10252.7 001304861.1_01322001_1 - 0.013 15.8 0.9 0.022 15.1 0.9 1.4 1 0 0 1 1 1 0 Casein kinase substrate phosphoprotein PP28 NADH_dh_m_C1 PF15088.4 001304851.1_01321001_1 - 0.018 14.5 0.0 0.11 12.0 0.0 2.0 2 0 0 2 2 2 0 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial Ribosomal_S25 PF03297.13 001304851.1_01321001_3 - 9.2e-50 166.9 8.0 1.3e-49 166.4 8.0 1.3 1 0 0 1 1 1 1 S25 ribosomal protein Mt_ATP-synt_D PF05873.10 001304851.1_01321001_3 - 0.016 14.9 0.2 0.021 14.6 0.2 1.1 1 0 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) TrmB PF01978.17 001304851.1_01321001_3 - 0.084 12.6 0.3 0.18 11.6 0.2 1.7 1 1 1 2 2 2 0 Sugar-specific transcriptional regulator TrmB Fe_dep_repress PF01325.17 001304851.1_01321001_3 - 0.085 12.9 0.1 0.15 12.2 0.1 1.4 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain AIPR PF10592.7 001304851.1_01321001_3 - 0.094 12.2 0.4 0.13 11.8 0.5 1.3 1 1 0 1 1 1 0 AIPR protein MarR_2 PF12802.5 001304851.1_01321001_3 - 0.11 12.3 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 MarR family HTH_24 PF13412.4 001304851.1_01321001_3 - 0.11 11.9 0.2 0.24 10.9 0.2 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Ribosomal_L37ae PF01780.17 001304924.1_01321001_2 - 6.1e-45 151.1 10.4 7.2e-45 150.9 10.4 1.1 1 0 0 1 1 1 1 Ribosomal L37ae protein family Elf1 PF05129.11 001304924.1_01321001_2 - 0.022 14.6 0.3 0.034 14.0 0.3 1.4 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like Zn_Tnp_IS1595 PF12760.5 001304924.1_01321001_2 - 0.05 13.5 2.0 0.085 12.7 2.0 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-C4_ClpX PF06689.11 001304924.1_01321001_2 - 0.085 12.6 3.7 0.3 10.9 3.7 2.0 1 1 0 1 1 1 0 ClpX C4-type zinc finger Ald_Xan_dh_C2 PF02738.16 001304853.1_01329001_1 - 1.5e-181 604.5 0.0 2e-181 604.0 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 001304853.1_01329001_1 - 1.9e-41 141.5 0.0 3.7e-41 140.6 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Fer2_2 PF01799.18 001304853.1_01329001_1 - 6.9e-30 102.7 0.3 2e-29 101.2 0.3 1.9 1 0 0 1 1 1 1 [2Fe-2S] binding domain Ald_Xan_dh_C PF01315.20 001304853.1_01329001_1 - 2e-29 102.0 2.4 6.4e-29 100.4 1.6 2.2 2 0 0 2 2 2 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.15 001304853.1_01329001_1 - 4e-29 100.7 0.0 1.9e-27 95.3 0.0 3.1 3 0 0 3 3 3 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.25 001304853.1_01329001_1 - 1.1e-08 34.8 1.9 4.2e-08 32.9 0.1 2.7 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain DUF218 PF02698.15 001304853.1_01329001_1 - 0.045 13.6 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 DUF218 domain Ribosomal_S6e PF01092.17 001304914.1_01322001_3 - 1.1e-69 232.1 0.1 1.1e-69 232.1 0.1 2.0 2 1 0 2 2 2 1 Ribosomal protein S6e DUF4574 PF15141.4 001304914.1_01322001_3 - 1.4 8.7 5.6 2.5 7.9 5.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4574) ubiquitin PF00240.21 001304907.1_01321001_3 - 6.9e-35 118.5 0.3 9.3e-35 118.1 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.15 001304907.1_01321001_3 - 5.5e-33 112.4 12.3 8.2e-33 111.9 12.3 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.6 001304907.1_01321001_3 - 7.7e-17 60.8 1.1 7.7e-17 60.8 0.4 1.4 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 001304907.1_01321001_3 - 4.7e-06 26.8 0.1 1.8e-05 25.0 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 001304907.1_01321001_3 - 0.0034 17.3 0.1 0.0069 16.4 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 001304907.1_01321001_3 - 0.043 14.2 0.1 0.047 14.1 0.1 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Ribosomal_S3Ae PF01015.16 001304860.1_01322001_1 - 3.2e-108 359.9 8.9 3.8e-108 359.7 8.9 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.14 001304860.1_01322001_1 - 0.0051 16.2 0.2 0.026 14.0 0.1 2.2 1 1 1 2 2 2 1 Partial alpha/beta-hydrolase lipase region Ribosomal_S11 PF00411.17 001304903.1_01321001_1 - 3.8e-47 159.1 0.4 4.9e-47 158.8 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 CBM_25 PF03423.11 001304903.1_01321001_1 - 0.081 13.1 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) RNase_H PF00075.22 001285939.1_01323001_1 - 7.6e-46 155.7 0.0 1.2e-45 155.1 0.0 1.3 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.14 001285939.1_01323001_1 - 1.3e-18 66.9 2.9 3.1e-18 65.7 2.9 1.7 1 0 0 1 1 1 1 Caulimovirus viroplasmin RVT_3 PF13456.4 001285939.1_01323001_1 - 0.00089 18.8 0.0 0.0027 17.3 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase-like Crystallin PF00525.16 001304874.1_01322001_1 - 5.1e-30 103.3 7.2 8.8e-30 102.6 7.2 1.4 1 0 0 1 1 1 1 Alpha crystallin A chain, N terminal HSP20 PF00011.19 001304874.1_01322001_1 - 2.6e-25 88.4 0.1 3.2e-25 88.1 0.1 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Ribosomal_L35Ae PF01247.16 001304936.1_01321001_1 - 5.6e-48 161.0 0.4 6.3e-48 160.8 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.16 001304936.1_01321001_1 - 0.0097 16.0 0.0 0.88 9.7 0.0 2.1 2 0 0 2 2 2 2 RimM N-terminal domain DUF2080 PF09853.7 001304936.1_01321001_1 - 0.041 13.5 0.2 0.2 11.3 0.0 2.2 2 1 1 3 3 3 0 Putative transposon-encoded protein (DUF2080) Ald_Xan_dh_C2 PF02738.16 001304852.1_01329001_1 - 1.9e-187 623.9 0.0 2.5e-187 623.5 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 001304852.1_01329001_1 - 2.7e-46 157.3 0.0 7.6e-46 155.8 0.0 1.8 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.20 001304852.1_01329001_1 - 2.2e-31 108.4 0.2 4e-31 107.5 0.2 1.5 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.18 001304852.1_01329001_1 - 1.9e-30 104.5 0.2 5.1e-30 103.1 0.2 1.7 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.15 001304852.1_01329001_1 - 5e-30 103.6 0.0 3.8e-28 97.5 0.0 2.8 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.25 001304852.1_01329001_1 - 2.2e-08 33.8 2.1 2.5e-08 33.6 0.1 2.3 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain DHODB_Fe-S_bind PF10418.7 001304852.1_01329001_1 - 0.081 12.6 3.8 0.035 13.8 0.8 2.0 2 0 0 2 2 2 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B DUF846 PF05832.10 001281868.1_01322001_3 - 1.7e-55 186.8 10.1 2.1e-55 186.4 10.1 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) TMC PF07810.11 001281868.1_01322001_3 - 0.071 13.6 3.3 0.13 12.7 3.3 1.7 1 1 0 1 1 1 0 TMC domain TMEM192 PF14802.4 001281868.1_01322001_3 - 0.092 11.7 0.2 0.16 10.9 0.2 1.3 1 0 0 1 1 1 0 TMEM192 family HXXEE PF13787.4 001281868.1_01322001_3 - 1.4 9.6 8.2 9.1 7.0 2.1 2.1 1 1 1 2 2 2 0 Protein of unknown function with HXXEE motif Ribosomal_L2_C PF03947.16 001304842.1_01322001_3 - 1e-48 164.5 3.1 1.6e-48 163.9 3.1 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.21 001304842.1_01322001_3 - 2.2e-19 69.0 0.2 7.6e-19 67.3 0.2 1.9 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain Ribosomal_L18 PF17135.2 001304908.1_01322001_1 - 1.8e-95 317.6 3.9 2e-95 317.4 3.9 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.17 001304908.1_01322001_1 - 0.014 16.0 0.1 0.024 15.2 0.1 1.5 1 1 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Ribosomal_S19e PF01090.17 001304868.1_01321001_2 - 1.6e-58 196.2 0.2 1.8e-58 196.0 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e HTH_12 PF08461.8 001304868.1_01321001_2 - 0.062 13.1 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain HTH_IclR PF09339.8 001304868.1_01321001_2 - 0.085 12.5 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain Ribosomal_S8e PF01201.20 001304920.1_01322001_3 - 3.1e-63 211.9 1.0 3.6e-63 211.6 1.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e EF-hand_8 PF13833.4 001304864.1_01322001_3 - 9.9e-28 95.6 17.8 5.4e-15 54.8 0.4 3.5 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_7 PF13499.4 001304864.1_01322001_3 - 4e-26 91.1 10.2 4.3e-15 55.8 6.7 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 001304864.1_01322001_3 - 2.6e-25 85.9 24.6 4.3e-08 32.0 1.0 4.8 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.4 001304864.1_01322001_3 - 4.8e-20 69.6 14.6 3.4e-07 29.5 0.4 4.8 4 1 1 5 5 5 4 EF-hand domain EF-hand_5 PF13202.4 001304864.1_01322001_3 - 7.4e-15 53.6 19.7 3e-06 26.4 0.5 4.9 4 1 1 5 5 5 3 EF hand EF-hand_9 PF14658.4 001304864.1_01322001_3 - 6.4e-12 45.5 1.3 2.5e-05 24.4 0.4 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 001304864.1_01322001_3 - 9.2e-06 25.4 7.8 0.02 14.7 0.0 3.1 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 001304864.1_01322001_3 - 8.2e-05 22.8 1.7 0.0023 18.1 0.5 2.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.11 001304864.1_01322001_3 - 0.0042 16.9 0.1 1.8 8.4 0.0 2.3 1 1 0 2 2 2 2 Tellurite resistance protein TerB EF-hand_10 PF14788.4 001304864.1_01322001_3 - 0.015 15.0 1.5 0.27 11.0 0.7 2.7 1 1 1 2 2 2 0 EF hand EF-hand_11 PF08976.9 001304864.1_01322001_3 - 0.056 14.2 0.1 0.36 11.6 0.1 2.0 1 1 0 2 2 2 0 EF-hand domain DUF1707 PF08044.9 001304864.1_01322001_3 - 0.075 13.0 0.1 17 5.4 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1707) UPF0154 PF03672.11 001304864.1_01322001_3 - 0.098 12.6 0.0 17 5.4 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) DUF1456 PF07308.11 001304864.1_01322001_3 - 0.33 11.2 1.9 16 5.8 0.2 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1456) Ribosomal_L1 PF00687.19 001304849.1_01322001_1 - 9.2e-44 149.5 4.2 1.1e-43 149.2 4.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF3671 PF12420.6 001304849.1_01322001_1 - 0.059 13.3 2.5 0.1 12.6 2.5 1.4 1 1 0 1 1 1 0 Protein of unknown function Tetraspannin PF00335.18 001304912.1_01322001_1 - 3.3e-45 154.4 11.2 3.7e-45 154.2 11.2 1.0 1 0 0 1 1 1 1 Tetraspanin family CD20 PF04103.13 001304912.1_01322001_1 - 0.01 15.8 9.0 0.18 11.8 9.0 2.2 1 1 0 1 1 1 0 CD20-like family DUF2371 PF10177.7 001304912.1_01322001_1 - 0.051 13.6 2.8 1.6 8.7 0.0 3.1 3 1 0 3 3 3 0 Uncharacterised conserved protein (DUF2371) DUF4239 PF14023.4 001304912.1_01322001_1 - 0.062 12.9 0.8 0.12 12.0 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) DUF4064 PF13273.4 001304912.1_01322001_1 - 0.1 12.9 12.6 2.5 8.4 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) OppC_N PF12911.5 001304912.1_01322001_1 - 1.3 9.0 6.3 6.8 6.7 0.1 3.3 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C DUF3098 PF11297.6 001304912.1_01322001_1 - 2.6 7.6 0.0 2.6 7.6 0.0 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF3098) DUF2207 PF09972.7 001304912.1_01322001_1 - 4.9 5.7 12.9 2.9e+02 -0.2 12.8 2.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Ribosomal_S17_N PF16205.3 001304884.1_01322001_3 - 5.4e-37 125.9 0.8 5.4e-37 125.9 0.8 1.7 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.18 001304884.1_01322001_3 - 1.4e-29 101.8 1.7 2.5e-29 101.1 1.7 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 PRF PF06875.9 001304884.1_01322001_3 - 0.12 11.6 0.1 0.19 11.0 0.1 1.2 1 0 0 1 1 1 0 Plethodontid receptivity factor PRF Ribosomal_L18A PF01775.15 001304881.1_01322001_2 - 5.3e-56 187.8 0.0 6.8e-56 187.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A P12 PF12669.5 001304893.1_01323001_2 - 9 6.7 8.9 23 5.4 8.9 1.7 1 0 0 1 1 1 0 Virus attachment protein p12 family Ribosomal_L3 PF00297.20 001304893.1_01323001_3 - 2.2e-193 642.1 11.2 2.5e-193 641.9 11.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 Ribosomal_L6 PF00347.21 001304933.1_01322001_2 - 2.1e-33 114.7 1.4 1.2e-15 57.8 0.3 2.2 2 0 0 2 2 2 2 Ribosomal protein L6 Lipocalin PF00061.21 001304848.1_01321001_3 - 2.9e-18 66.3 2.6 3.4e-18 66.1 2.6 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 001304848.1_01321001_3 - 0.00052 19.8 0.7 0.002 17.9 0.7 1.8 1 1 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Globin PF00042.20 001304883.1_01322001_3 - 4.9e-32 110.6 0.3 6.3e-31 107.0 0.0 2.0 2 0 0 2 2 2 1 Globin BCA_ABC_TP_C PF12399.6 001304883.1_01322001_3 - 0.0071 16.1 1.4 0.094 12.5 0.0 2.3 2 0 0 2 2 2 1 Branched-chain amino acid ATP-binding cassette transporter DUF4006 PF13179.4 001304919.1_01321001_3 - 0.0026 17.5 0.0 0.0042 16.8 0.0 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF4006) Ribosomal_L13 PF00572.16 001304873.1_01322001_1 - 4.1e-10 39.9 0.5 7.8e-09 35.7 0.0 2.7 2 1 0 2 2 2 1 Ribosomal protein L13 Ribosomal_L31e PF01198.17 001304898.1_01321001_1 - 1.4e-53 179.0 0.9 1.8e-53 178.6 0.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L31e Vsr PF03852.13 001304898.1_01321001_1 - 0.0078 15.9 0.1 0.017 14.8 0.0 1.6 1 1 0 1 1 1 1 DNA mismatch endonuclease Vsr Ribosomal_L32e PF01655.16 001304930.1_01321001_3 - 5.6e-61 203.5 2.6 6.6e-61 203.3 2.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 Ribosomal_L5 PF00281.17 001304880.1_01322001_1 - 4.2e-23 81.3 0.0 2.2e-21 75.8 0.0 2.2 2 0 0 2 2 2 2 Ribosomal protein L5 Ribosomal_L5_C PF00673.19 001304880.1_01322001_1 - 1.3e-21 76.5 0.0 1.9e-21 75.9 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L6e PF01159.17 001304902.1_01322001_2 - 4e-45 152.6 1.7 4e-45 152.6 1.7 2.5 3 0 0 3 3 3 1 Ribosomal protein L6e Ribosomal_L6e_N PF03868.13 001304902.1_01322001_2 - 3.3e-35 120.0 10.9 3.3e-35 120.0 10.9 2.8 3 1 0 3 3 3 1 Ribosomal protein L6, N-terminal domain Ferritin PF00210.22 001304921.1_01322001_2 - 1.5e-28 99.4 0.1 1.9e-28 99.1 0.1 1.1 1 0 0 1 1 1 1 Ferritin-like domain ANAPC4 PF12896.5 001304921.1_01322001_2 - 0.0093 15.3 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 Ribosomal_L10 PF00466.18 001304894.1_01322001_3 - 3.1e-22 78.5 0.0 5.9e-22 77.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.17 001304894.1_01322001_3 - 1.2e-20 73.7 5.2 1.2e-20 73.7 5.2 1.8 2 0 0 2 2 2 1 60s Acidic ribosomal protein Ribosomal_S8 PF00410.17 001304877.1_01321001_2 - 2.7e-22 78.9 0.0 3.8e-22 78.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 Dickkopf_N PF04706.10 001304925.1_01324001_3 - 4e-17 62.3 17.4 4e-17 62.3 17.4 3.3 3 1 1 4 4 4 2 Dickkopf N-terminal cysteine-rich region Ribosomal_L28e PF01778.15 001304854.1_01321001_2 - 3.9e-36 124.1 1.8 4.8e-36 123.8 1.8 1.1 1 0 0 1 1 1 1 Ribosomal L28e protein family MipZ PF09140.9 001304854.1_01321001_2 - 0.022 13.9 0.1 0.023 13.8 0.1 1.2 1 0 0 1 1 1 0 ATPase MipZ Ribosomal_L7Ae PF01248.24 001304913.1_01321001_3 - 2.8e-30 103.8 1.8 3.5e-30 103.5 1.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family HAD PF12710.5 001304913.1_01321001_3 - 0.085 13.1 0.0 0.098 12.9 0.0 1.1 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase MHC_I PF00129.16 001304845.1_01323001_1 - 3.2e-94 313.4 0.6 4.4e-94 312.9 0.6 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001304845.1_01323001_1 - 2.5e-17 63.0 0.0 5.5e-17 61.9 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001304845.1_01323001_1 - 4.6e-12 45.5 1.0 9.7e-12 44.5 1.0 1.6 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 001304845.1_01323001_1 - 2.3e-05 24.8 1.2 0.095 13.2 0.0 3.0 1 1 1 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001304845.1_01323001_1 - 0.00027 20.8 0.2 0.00078 19.3 0.2 1.8 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001304845.1_01323001_1 - 0.0032 17.5 0.0 0.011 15.8 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 001304845.1_01323001_1 - 0.032 14.4 0.0 0.081 13.2 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain EphA2_TM PF14575.4 001304845.1_01323001_1 - 0.081 13.6 0.0 0.19 12.4 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain ATP-synt_F PF01990.15 001304878.1_01321001_2 - 1.5e-32 111.7 0.2 1.7e-32 111.5 0.2 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit Auto_anti-p27 PF06677.10 001304889.1_01322001_1 - 9.2e-17 60.8 2.8 1.5e-16 60.1 2.8 1.3 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) OrfB_Zn_ribbon PF07282.9 001304889.1_01322001_1 - 0.071 12.9 0.5 0.15 11.9 0.5 1.5 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-dskA_traR PF01258.15 001304889.1_01322001_1 - 0.54 10.1 3.6 4.8 7.1 0.3 2.5 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger Dsh_C PF12316.6 001304889.1_01322001_2 - 0.12 12.7 0.3 0.12 12.7 0.3 2.0 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal adh_short_C2 PF13561.4 001278922.1_01322001_1 - 3.8e-62 209.8 0.1 4.8e-62 209.4 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.23 001278922.1_01322001_1 - 2e-50 170.9 0.3 2.4e-50 170.6 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.8 001278922.1_01322001_1 - 5.2e-11 42.6 0.1 7.7e-11 42.1 0.1 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.8 001278922.1_01322001_1 - 0.019 14.2 0.0 0.028 13.7 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) DFP PF04127.13 001278922.1_01322001_1 - 0.042 13.6 0.8 0.14 11.9 0.3 1.8 1 1 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein F420_oxidored PF03807.15 001278922.1_01322001_1 - 0.051 14.0 0.1 0.11 13.0 0.1 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Orn_Arg_deC_N PF02784.14 001291458.1_01329001_2 - 9.8e-64 215.0 0.1 1.3e-63 214.7 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001291458.1_01329001_2 - 4.3e-24 84.6 0.0 7.4e-24 83.8 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Ribosomal_L16 PF00252.16 001304855.1_01322001_3 - 1.5e-44 151.0 0.3 1.9e-44 150.8 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Filament PF00038.19 001195239.1_22425001_1 - 1.9e-100 336.4 39.6 2.2e-100 336.1 39.6 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001195239.1_22425001_1 - 4.5e-20 72.3 31.4 1.9e-17 63.8 4.9 3.3 2 1 1 3 3 2 2 Keratin type II head CENP-F_leu_zip PF10473.7 001195239.1_22425001_1 - 4.3e-05 23.4 34.2 0.004 17.1 9.3 3.6 1 1 3 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Alanine_zipper PF11839.6 001195239.1_22425001_1 - 0.0035 17.5 4.5 0.0035 17.5 4.5 2.5 2 0 0 2 2 2 1 Alanine-zipper, major outer membrane lipoprotein TPR_MLP1_2 PF07926.10 001195239.1_22425001_1 - 0.004 17.1 4.4 0.004 17.1 4.4 4.0 2 2 1 4 4 4 2 TPR/MLP1/MLP2-like protein DUF1732 PF08340.9 001195239.1_22425001_1 - 0.01 15.7 2.9 2.5 8.0 0.2 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1732) Spc7 PF08317.9 001195239.1_22425001_1 - 0.024 13.4 37.7 0.018 13.8 7.9 3.4 1 1 2 3 3 3 0 Spc7 kinetochore protein Reo_sigmaC PF04582.10 001195239.1_22425001_1 - 0.035 13.4 8.3 0.1 11.8 1.5 2.5 1 1 0 2 2 2 0 Reovirus sigma C capsid protein DUF1664 PF07889.10 001195239.1_22425001_1 - 0.039 13.8 21.5 0.21 11.5 2.3 4.5 2 1 4 6 6 6 0 Protein of unknown function (DUF1664) IncA PF04156.12 001195239.1_22425001_1 - 0.081 12.6 36.3 0.04 13.6 14.0 3.3 1 1 0 2 2 2 0 IncA protein Phage_GP20 PF06810.9 001195239.1_22425001_1 - 0.18 11.4 24.1 0.41 10.3 0.8 3.9 2 2 2 4 4 4 0 Phage minor structural protein GP20 DUF5082 PF16888.3 001195239.1_22425001_1 - 0.48 10.7 26.8 0.085 13.1 4.5 4.0 1 1 4 5 5 5 0 Domain of unknown function (DUF5082) AAA_13 PF13166.4 001195239.1_22425001_1 - 0.48 8.9 24.7 0.021 13.4 17.8 2.0 1 1 0 1 1 1 0 AAA domain DUF4407 PF14362.4 001195239.1_22425001_1 - 0.56 9.4 21.6 0.11 11.8 1.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Baculo_PEP_C PF04513.10 001195239.1_22425001_1 - 0.56 10.1 16.5 0.12 12.3 2.9 3.4 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4337 PF14235.4 001195239.1_22425001_1 - 0.68 9.9 12.6 0.27 11.2 5.3 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4337) FlaC_arch PF05377.9 001195239.1_22425001_1 - 1.2 9.5 19.8 5.8 7.3 0.1 5.7 5 2 2 7 7 7 0 Flagella accessory protein C (FlaC) Jnk-SapK_ap_N PF09744.7 001195239.1_22425001_1 - 1.3 9.1 31.3 0.13 12.3 5.1 3.4 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 JIP_LZII PF16471.3 001195239.1_22425001_1 - 1.7 8.7 21.5 16 5.6 0.6 5.2 3 1 2 5 5 5 0 JNK-interacting protein leucine zipper II ATG16 PF08614.9 001195239.1_22425001_1 - 2.6 8.0 34.7 1.1 9.3 5.6 3.8 1 1 2 4 4 4 0 Autophagy protein 16 (ATG16) TMPIT PF07851.11 001195239.1_22425001_1 - 2.7 7.0 20.6 0.2 10.7 4.3 2.7 1 1 1 3 3 3 0 TMPIT-like protein CALCOCO1 PF07888.9 001195239.1_22425001_1 - 2.7 6.3 31.0 1.5 7.2 9.2 2.1 1 1 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like V_ATPase_I PF01496.17 001195239.1_22425001_1 - 2.8 5.6 20.8 0.1 10.3 5.0 2.2 1 1 0 2 2 2 0 V-type ATPase 116kDa subunit family NPV_P10 PF05531.10 001195239.1_22425001_1 - 2.8 8.3 13.4 0.96 9.8 0.8 4.1 2 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein ADIP PF11559.6 001195239.1_22425001_1 - 3.9 7.4 28.2 0.11 12.5 9.1 3.4 1 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding DUF948 PF06103.9 001195239.1_22425001_1 - 4.8 7.4 6.4 3.5 7.8 1.8 3.0 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Atg14 PF10186.7 001195239.1_22425001_1 - 5.9 5.7 23.1 0.047 12.6 10.0 2.3 1 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 TraC PF07820.10 001195239.1_22425001_1 - 7.9 6.8 11.7 1.1 9.5 4.7 2.9 3 0 0 3 3 3 0 TraC-like protein Rootletin PF15035.4 001195239.1_22425001_1 - 9.1 6.2 28.1 5.6 6.9 7.3 2.4 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion SSF PF00474.15 001195405.1_22424001_1 - 1.9e-171 570.3 24.2 1.9e-171 570.3 24.2 1.8 2 0 0 2 2 2 1 Sodium:solute symporter family TadF PF16964.3 001195405.1_22424001_1 - 0.016 14.8 0.0 0.033 13.8 0.0 1.4 1 0 0 1 1 1 0 Putative tight adherence pilin protein F DUF3754 PF12576.6 001195405.1_22424001_1 - 0.21 11.5 0.8 0.73 9.7 0.8 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3754) SLC35F PF06027.10 001101659.1_22424001_2 - 1.4e-142 474.5 27.0 1.7e-142 474.2 27.0 1.1 1 0 0 1 1 1 1 Solute carrier family 35 CRT-like PF08627.8 001101659.1_22424001_2 - 6.4e-10 38.4 4.1 6.4e-10 38.4 4.1 2.1 1 1 1 2 2 2 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.18 001101659.1_22424001_2 - 7.6e-10 39.0 29.9 7.7e-07 29.2 15.3 2.1 2 0 0 2 2 2 2 EamA-like transporter family p450 PF00067.20 001195406.1_22424001_1 - 4.1e-129 431.2 0.0 4.7e-129 431.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 RLL PF10036.7 001195406.1_22424001_1 - 0.19 11.4 0.0 0.29 10.8 0.0 1.2 1 0 0 1 1 1 0 Putative carnitine deficiency-associated protein MACPF PF01823.17 001101660.1_22424001_1 - 3.5e-34 118.6 0.0 4.3e-34 118.3 0.0 1.1 1 0 0 1 1 1 1 MAC/Perforin domain C2 PF00168.28 001101660.1_22424001_1 - 1.4e-08 34.8 0.0 3.5e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 C2 domain Kunitz_BPTI PF00014.21 001198554.1_22423001_2 - 6e-32 109.5 20.9 3.5e-16 59.0 7.1 2.6 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Lipocalin PF00061.21 001198554.1_22423001_2 - 2.5e-31 108.7 0.1 3.3e-31 108.3 0.1 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lamp PF01299.15 001163655.1_22425001_2 - 3.7e-133 443.8 1.2 2.7e-126 421.3 0.5 2.0 1 1 1 2 2 2 2 Lysosome-associated membrane glycoprotein (Lamp) ATP-synt_S1 PF05827.10 001163655.1_22425001_2 - 2.1e-06 27.5 2.0 0.00081 19.1 0.0 2.2 2 0 0 2 2 2 2 Vacuolar ATP synthase subunit S1 (ATP6S1) S_100 PF01023.17 001198929.1_22421001_1 - 4.2e-18 64.7 0.0 6.1e-18 64.1 0.0 1.3 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 001198929.1_22421001_1 - 4.9e-07 30.0 0.9 6.8e-07 29.5 0.9 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 001198929.1_22421001_1 - 1.8e-06 26.9 1.3 6.1e-06 25.3 0.5 2.0 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.4 001198929.1_22421001_1 - 0.00017 21.1 0.2 0.00027 20.5 0.2 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 001198929.1_22421001_1 - 0.0023 17.6 0.6 0.011 15.5 0.2 2.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_4 PF12763.5 001198929.1_22421001_1 - 0.0058 16.4 0.2 0.0081 16.0 0.2 1.2 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.4 001198929.1_22421001_1 - 0.4 10.2 4.0 0.53 9.8 1.7 2.1 2 0 0 2 2 2 0 EF hand OST-HTH PF12872.5 001110448.1_22423001_1 - 0.14 12.0 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 OST-HTH/LOTUS domain Band_7 PF01145.23 001110448.1_22423001_3 - 9.1e-27 94.1 1.5 1.2e-26 93.6 1.5 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Med2 PF11214.6 001110448.1_22423001_3 - 0.013 15.6 0.4 0.02 14.9 0.4 1.3 1 0 0 1 1 1 0 Mediator complex subunit 2 CFTR_R PF14396.4 001048009.1_22429001_2 - 7.1e-100 332.8 1.0 1.1e-99 332.2 1.0 1.3 1 0 0 1 1 1 1 Cystic fibrosis TM conductance regulator (CFTR), regulator domain ABC_membrane PF00664.21 001048009.1_22429001_2 - 2.7e-93 312.5 43.4 9.6e-50 169.6 20.2 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 001048009.1_22429001_2 - 9.1e-59 197.7 0.0 1.3e-32 113.0 0.0 2.7 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.4 001048009.1_22429001_2 - 1.8e-07 31.1 1.1 0.029 14.0 0.1 3.4 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.17 001048009.1_22429001_2 - 4.8e-07 29.3 1.1 0.062 12.6 0.0 3.7 3 2 0 4 4 4 2 RecF/RecN/SMC N terminal domain T2SSE PF00437.18 001048009.1_22429001_2 - 2.3e-06 26.8 0.0 0.011 14.7 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_29 PF13555.4 001048009.1_22429001_2 - 4.5e-06 26.1 1.0 0.00092 18.7 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF258 PF03193.14 001048009.1_22429001_2 - 5.5e-06 26.3 0.4 0.026 14.3 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function, DUF258 DUF87 PF01935.15 001048009.1_22429001_2 - 5.1e-05 23.3 1.1 0.015 15.2 0.1 2.6 2 0 0 2 2 2 1 Domain of unknown function DUF87 AAA_16 PF13191.4 001048009.1_22429001_2 - 0.00028 21.2 0.0 0.51 10.6 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.21 001048009.1_22429001_2 - 0.00045 20.2 0.4 0.081 12.9 0.1 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase NACHT PF05729.10 001048009.1_22429001_2 - 0.00076 19.3 0.4 1.5 8.6 0.0 2.6 2 0 0 2 2 2 2 NACHT domain Zeta_toxin PF06414.10 001048009.1_22429001_2 - 0.002 17.3 0.7 0.21 10.7 0.1 2.4 2 0 0 2 2 2 1 Zeta toxin ArgK PF03308.14 001048009.1_22429001_2 - 0.0036 16.2 1.0 0.013 14.4 0.1 2.1 2 0 0 2 2 2 1 ArgK protein AAA_22 PF13401.4 001048009.1_22429001_2 - 0.0047 17.1 0.8 3.2 7.9 0.0 2.9 3 0 0 3 3 2 1 AAA domain NTPase_1 PF03266.13 001048009.1_22429001_2 - 0.0055 16.5 0.1 0.19 11.5 0.0 2.6 3 0 0 3 3 2 1 NTPase FtsK_SpoIIIE PF01580.16 001048009.1_22429001_2 - 0.021 14.1 0.5 2.6 7.2 0.1 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_30 PF13604.4 001048009.1_22429001_2 - 0.034 13.7 0.0 1.6 8.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain MobB PF03205.12 001048009.1_22429001_2 - 0.036 13.9 3.1 4.4 7.1 0.2 3.4 4 0 0 4 4 3 0 Molybdopterin guanine dinucleotide synthesis protein B TsaE PF02367.15 001048009.1_22429001_2 - 0.036 13.9 0.6 12 5.7 0.1 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.20 001048009.1_22429001_2 - 0.037 12.9 0.1 0.96 8.3 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain AAA_19 PF13245.4 001048009.1_22429001_2 - 0.043 14.0 0.1 15 5.7 0.0 3.0 3 0 0 3 3 3 0 AAA domain cobW PF02492.17 001048009.1_22429001_2 - 0.055 12.9 2.2 5.9 6.3 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.11 001048009.1_22429001_2 - 0.058 13.5 0.1 15 5.7 0.0 3.4 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase TrwB_AAD_bind PF10412.7 001048009.1_22429001_2 - 0.12 11.1 0.6 2.7 6.7 0.0 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain ATP-synt_ab PF00006.23 001048009.1_22429001_2 - 0.15 11.5 0.0 11 5.4 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Dynamin_N PF00350.21 001048009.1_22429001_2 - 0.15 12.0 0.6 23 4.9 0.2 2.7 2 0 0 2 2 2 0 Dynamin family AAA_23 PF13476.4 001048009.1_22429001_2 - 0.18 12.2 11.4 0.92 9.8 0.0 3.5 4 0 0 4 4 3 0 AAA domain AAA_18 PF13238.4 001048009.1_22429001_2 - 0.18 12.2 0.1 1.9 8.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.4 001048009.1_22429001_2 - 0.22 10.9 0.6 14 5.1 0.1 2.3 2 0 0 2 2 2 0 AAA domain zf-U1 PF06220.10 001009384.1_22423001_1 - 0.84 9.3 4.3 1.6 8.4 4.3 1.4 1 0 0 1 1 1 0 U1 zinc finger I-set PF07679.14 001009384.1_22423001_2 - 1.1e-28 99.0 0.0 1.6e-28 98.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001009384.1_22423001_2 - 4e-14 52.8 0.0 6.8e-14 52.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001009384.1_22423001_2 - 1.9e-11 43.9 0.0 2.8e-11 43.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001009384.1_22423001_2 - 1.3e-06 28.5 0.0 2.1e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 001009384.1_22423001_2 - 0.00024 21.1 0.1 0.024 14.6 0.1 2.2 1 1 0 1 1 1 1 Immunoglobulin V-set domain Cathelicidins PF00666.15 001204778.1_22422001_2 - 8.6e-47 157.5 0.5 1.1e-46 157.1 0.5 1.1 1 0 0 1 1 1 1 Cathelicidin CAP18_C PF12153.6 001204778.1_22422001_2 - 1.5e-12 47.1 8.1 2.7e-12 46.3 8.1 1.5 1 0 0 1 1 1 1 LPS binding domain of CAP18 (C terminal) Cystatin PF00031.19 001204778.1_22422001_2 - 0.00012 22.1 0.9 0.0018 18.4 0.9 2.0 1 1 0 1 1 1 1 Cystatin domain Spp-24 PF07448.9 001204778.1_22422001_2 - 0.026 14.6 0.1 0.043 13.9 0.1 1.4 1 0 0 1 1 1 0 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Ectatomin PF06457.9 001204778.1_22422001_2 - 0.15 11.9 0.5 0.85 9.5 0.3 2.0 2 0 0 2 2 2 0 Ectatomin LRR_8 PF13855.4 001079829.1_22426001_1 - 2.7e-78 257.5 96.3 4.9e-13 48.5 3.3 11.9 5 4 9 14 14 14 13 Leucine rich repeat LRR_4 PF12799.5 001079829.1_22426001_1 - 1.8e-30 104.3 100.1 4.8e-05 23.5 1.8 13.5 8 2 6 14 14 14 11 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001079829.1_22426001_1 - 7.7e-19 67.8 21.2 5.3e-05 23.0 0.4 5.7 3 1 3 6 6 6 5 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001079829.1_22426001_1 - 7.9e-11 41.6 30.8 0.01 15.2 0.3 7.1 2 2 3 7 7 7 5 Leucine-rich repeat TIR PF01582.18 001079829.1_22426001_1 - 1.2e-09 38.1 0.4 2.1e-09 37.3 0.4 1.4 1 0 0 1 1 1 1 TIR domain LRR_1 PF00560.31 001079829.1_22426001_1 - 6.5e-08 31.8 84.9 0.91 10.1 0.2 19.4 19 1 0 19 19 19 5 Leucine Rich Repeat LRRNT PF01462.16 001079829.1_22426001_1 - 0.016 14.7 0.4 0.016 14.7 0.4 1.9 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain TIR_2 PF13676.4 001079829.1_22426001_1 - 0.018 15.2 0.1 0.034 14.3 0.1 1.4 1 0 0 1 1 1 0 TIR domain HTH_25 PF13413.4 001079829.1_22426001_1 - 0.078 12.7 0.1 27 4.6 0.0 4.1 4 0 0 4 4 4 0 Helix-turn-helix domain 3Beta_HSD PF01073.17 001246194.1_22424001_1 - 7.2e-113 376.1 0.0 8.7e-113 375.8 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 001246194.1_22424001_1 - 4.1e-19 68.9 0.0 5.9e-19 68.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.10 001246194.1_22424001_1 - 3.4e-15 55.8 0.1 1.2e-14 54.0 0.1 1.7 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.3 001246194.1_22424001_1 - 1.9e-11 43.8 0.1 9e-11 41.6 0.0 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.13 001246194.1_22424001_1 - 1.9e-09 37.0 0.0 3e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.4 001246194.1_22424001_1 - 8.1e-08 32.2 0.0 1.2e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.15 001246194.1_22424001_1 - 3.9e-05 22.7 0.0 6.2e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Sacchrp_dh_NADP PF03435.16 001246194.1_22424001_1 - 0.00089 19.4 0.0 0.0016 18.5 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NmrA PF05368.11 001246194.1_22424001_1 - 0.00092 18.7 0.0 0.0014 18.1 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family KR PF08659.8 001246194.1_22424001_1 - 0.0089 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 KR domain Porphobil_deam PF01379.18 001177808.1_22423001_1 - 6.5e-79 264.1 0.0 1.1e-78 263.4 0.0 1.3 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.13 001177808.1_22423001_1 - 1.4e-22 79.7 0.0 1.2e-21 76.7 0.0 2.4 1 1 1 2 2 2 1 Porphobilinogen deaminase, C-terminal domain CbiJ PF02571.12 001177808.1_22423001_1 - 0.052 12.9 0.1 12 5.2 0.0 2.7 3 0 0 3 3 3 0 Precorrin-6x reductase CbiJ/CobK MGS PF02142.20 001177808.1_22423001_1 - 0.06 13.4 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 MGS-like domain eRF1_2 PF03464.13 001177808.1_22423001_1 - 0.074 13.2 0.1 0.2 11.8 0.0 1.6 2 0 0 2 2 2 0 eRF1 domain 2 Porphobil_deam PF01379.18 001177809.1_22423001_2 - 7.2e-79 264.0 0.0 1.2e-78 263.3 0.0 1.3 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.13 001177809.1_22423001_2 - 1.6e-22 79.5 0.0 1.3e-21 76.6 0.0 2.3 1 1 1 2 2 2 1 Porphobilinogen deaminase, C-terminal domain MGS PF02142.20 001177809.1_22423001_2 - 0.065 13.3 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 MGS-like domain eRF1_2 PF03464.13 001177809.1_22423001_2 - 0.079 13.1 0.1 0.21 11.8 0.0 1.6 2 0 0 2 2 2 0 eRF1 domain 2 FOXP-CC PF16159.3 001113177.1_22425001_1 - 3.3e-35 120.4 4.2 3.3e-35 120.4 4.2 4.6 4 1 1 5 5 5 1 FOXP coiled-coil domain Forkhead PF00250.16 001113177.1_22425001_1 - 2.8e-28 97.9 0.2 1e-27 96.1 0.2 2.0 1 0 0 1 1 1 1 Forkhead domain TT_ORF1 PF02956.12 001113177.1_22425001_1 - 1.1 7.7 18.4 1.8 7.0 18.4 1.2 1 0 0 1 1 1 0 TT viral orf 1 hDGE_amylase PF14701.4 001113177.1_22425001_1 - 2.4 7.0 13.1 5.3 5.9 13.1 1.5 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Plasmodium_Vir PF05795.9 001113177.1_22425001_1 - 3.5 6.8 7.9 7.6 5.7 5.9 2.2 2 0 0 2 2 2 0 Plasmodium vivax Vir protein RR_TM4-6 PF06459.10 001113177.1_22425001_1 - 9.5 5.8 18.8 23 4.6 18.8 1.7 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 p450 PF00067.20 001246271.1_22425001_3 - 1.5e-130 436.0 0.2 1.7e-130 435.8 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_C14 PF00656.20 001146147.1_22424001_3 - 7.2e-44 150.5 0.0 1.4e-43 149.5 0.0 1.5 1 0 0 1 1 1 1 Caspase domain CARD PF00619.19 001146147.1_22424001_3 - 1.1e-05 25.2 1.2 0.047 13.6 0.1 2.8 3 0 0 3 3 3 2 Caspase recruitment domain DUF948 PF06103.9 001146147.1_22424001_3 - 0.32 11.2 0.9 30 4.8 0.0 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) MFMR_assoc PF16596.3 001146147.1_22424001_3 - 4.4 7.6 8.3 0.43 10.9 3.7 1.6 2 0 0 2 2 2 0 Disordered region downstream of MFMR Ephrin PF00812.15 001114343.1_22423001_1 - 1.3e-41 141.7 0.0 3e-41 140.5 0.0 1.5 2 0 0 2 2 2 1 Ephrin VEGF_C PF14554.4 001009854.1_22422001_3 - 2.9e-28 97.6 20.4 2.9e-28 97.6 20.4 2.2 2 1 1 3 3 3 1 VEGF heparin-binding domain PDGF PF00341.15 001009854.1_22422001_3 - 2.9e-27 94.6 4.5 2.9e-27 94.6 4.5 2.3 2 1 0 2 2 2 1 PDGF/VEGF domain CXCXC PF03128.12 001009854.1_22422001_3 - 3 8.4 20.3 0.82 10.1 0.8 3.8 3 0 0 3 3 3 0 CXCXC repeat Ephrin PF00812.15 001114344.1_22423001_1 - 2e-51 173.5 0.3 1.8e-50 170.4 0.1 2.0 2 0 0 2 2 2 1 Ephrin TMEM132D_C PF15706.3 001114344.1_22423001_1 - 0.0027 17.3 0.0 0.0051 16.4 0.0 1.4 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF4381 PF14316.4 001114344.1_22423001_1 - 0.042 14.0 0.0 0.069 13.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) TMEM154 PF15102.4 001114344.1_22423001_1 - 0.075 12.8 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family EphA2_TM PF14575.4 001114344.1_22423001_1 - 0.084 13.6 0.0 0.18 12.5 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain ECSCR PF15820.3 001114344.1_22423001_1 - 0.12 12.1 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator 7tm_1 PF00001.19 001048011.1_22423001_1 - 4.2e-43 147.4 11.4 6.2e-43 146.8 11.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) NdhL PF10716.7 001048011.1_22423001_1 - 0.045 13.6 0.3 0.045 13.6 0.3 2.4 3 0 0 3 3 3 0 NADH dehydrogenase transmembrane subunit Cullin PF00888.20 001246321.1_22426001_3 - 3.3e-186 620.4 17.6 4.8e-186 619.9 17.6 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.7 001246321.1_22426001_3 - 2e-18 66.0 7.1 6.6e-18 64.4 7.1 2.0 1 0 0 1 1 1 1 Cullin protein neddylation domain Stork_head PF10264.7 001246321.1_22426001_3 - 0.028 14.4 1.4 0.067 13.2 0.6 2.1 2 0 0 2 2 2 0 Winged helix Storkhead-box1 domain HMD PF03201.14 001246321.1_22426001_3 - 1.2 9.3 5.5 0.62 10.2 0.2 3.2 3 1 1 4 4 4 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase An_peroxidase PF03098.13 001122746.2_22425001_1 - 1.5e-182 607.7 0.0 1.9e-182 607.4 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase Ig_2 PF13895.4 001009205.1_22422001_1 - 1.5e-19 70.0 0.1 5.4e-10 39.4 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001009205.1_22422001_1 - 6.5e-14 52.2 0.7 7.9e-06 26.3 0.0 2.6 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.23 001009205.1_22422001_1 - 2e-08 34.2 0.4 0.0027 17.7 0.1 3.0 2 2 0 2 2 2 2 Immunoglobulin domain Ig_4 PF16680.3 001009205.1_22422001_1 - 2e-06 27.9 0.0 0.037 14.3 0.0 2.3 2 0 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain V-set PF07686.15 001009205.1_22422001_1 - 3.3e-06 27.1 0.3 0.19 11.8 0.3 3.4 2 1 0 2 2 2 2 Immunoglobulin V-set domain Ig_5 PF16681.3 001009205.1_22422001_1 - 0.00038 20.7 0.1 0.11 12.8 0.0 2.3 2 0 0 2 2 2 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain I-set PF07679.14 001009205.1_22422001_1 - 0.0006 19.7 4.8 1.2 9.1 0.1 4.0 3 2 0 3 3 3 2 Immunoglobulin I-set domain Beach PF02138.16 001290242.1_22429001_1 - 2.5e-112 374.6 1.2 4.5e-112 373.8 1.2 1.4 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.4 001290242.1_22429001_1 - 2.4e-22 78.8 0.0 6.1e-22 77.5 0.0 1.8 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.30 001290242.1_22429001_1 - 1.1e-07 32.3 10.1 0.07 13.9 0.0 6.1 4 1 1 5 5 5 3 WD domain, G-beta repeat DUF4800 PF16057.3 001290242.1_22429001_1 - 0.0097 15.1 2.5 0.016 14.4 1.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4800) DUF3361 PF11841.6 001290242.1_22429001_1 - 2.2 8.1 7.0 3.4 7.4 0.0 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3361) Zona_pellucida PF00100.21 001284435.1_22424001_1 - 3e-45 154.8 0.0 4e-45 154.4 0.0 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain Trefoil PF00088.16 001284435.1_22424001_1 - 0.01 15.6 7.5 0.01 15.6 7.5 2.5 2 1 1 3 3 3 0 Trefoil (P-type) domain Glyco_hydro_31 PF01055.24 001123332.1_22429001_3 - 9.9e-301 997.0 25.9 6.9e-155 516.4 7.1 2.2 2 0 0 2 2 2 2 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.3 001123332.1_22429001_3 - 3.6e-68 226.9 2.6 2.8e-34 117.7 0.9 2.6 2 0 0 2 2 2 2 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Trefoil PF00088.16 001123332.1_22429001_3 - 3.7e-18 65.0 14.3 5.4e-10 38.8 2.5 2.6 2 0 0 2 2 2 2 Trefoil (P-type) domain Gal_mutarotas_2 PF13802.4 001123332.1_22429001_3 - 1.5e-11 44.3 6.2 1.4e-05 25.2 0.3 3.0 2 0 0 2 2 2 2 Galactose mutarotase-like Ion_trans PF00520.29 001038605.2_22429001_2 - 2.8e-252 832.2 83.8 3.2e-69 232.8 17.9 4.1 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.3 001038605.2_22429001_2 - 1.8e-35 120.4 0.0 5.6e-35 118.9 0.0 1.9 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 001038605.2_22429001_2 - 6.1e-29 100.0 0.1 1.4e-28 98.9 0.1 1.6 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 001038605.2_22429001_2 - 5.9e-12 44.8 25.0 8.9e-10 37.7 10.2 9.1 6 4 2 9 9 9 3 Polycystin cation channel CAC1F_C PF16885.3 001038605.2_22429001_2 - 2.9e-06 27.1 6.9 8.5e-06 25.5 0.1 2.5 3 0 0 3 3 3 2 Voltage-gated calcium channel subunit alpha, C-term COX16 PF14138.4 001038605.2_22429001_2 - 0.45 10.9 2.0 9.1 6.7 0.1 3.3 3 0 0 3 3 3 0 Cytochrome c oxidase assembly protein COX16 DUF2670 PF10875.6 001038605.2_22429001_2 - 0.78 9.7 3.4 3.6 7.6 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2670) LRR_8 PF13855.4 001080133.1_22428001_2 - 6.5e-65 214.6 94.4 3.2e-09 36.3 0.7 14.9 8 4 7 15 15 15 14 Leucine rich repeat LRR_4 PF12799.5 001080133.1_22428001_2 - 3.2e-30 103.4 100.0 1.6e-05 25.0 2.5 15.4 8 5 9 17 17 17 13 Leucine Rich repeats (2 copies) TIR PF01582.18 001080133.1_22428001_2 - 2.1e-13 50.4 0.4 3.5e-13 49.6 0.4 1.3 1 0 0 1 1 1 1 TIR domain LRR_5 PF13306.4 001080133.1_22428001_2 - 1.4e-11 44.3 26.1 6.9e-05 22.7 0.3 6.8 5 1 2 7 7 7 4 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001080133.1_22428001_2 - 3.3e-06 26.6 42.9 0.05 13.0 3.8 7.3 3 3 5 8 8 8 4 Leucine-rich repeat LRR_6 PF13516.4 001080133.1_22428001_2 - 9.3e-06 25.2 60.3 2 8.5 0.3 17.6 19 0 0 19 19 19 4 Leucine Rich repeat LRR_1 PF00560.31 001080133.1_22428001_2 - 8.6e-05 22.3 81.9 5.1 7.8 0.0 21.4 22 4 0 22 22 22 5 Leucine Rich Repeat TIR_2 PF13676.4 001080133.1_22428001_2 - 0.0011 19.2 0.0 0.0021 18.2 0.0 1.5 1 0 0 1 1 1 1 TIR domain Tetrabrachion PF11401.6 001080133.1_22428001_2 - 0.15 12.0 0.2 0.87 9.5 0.0 2.4 2 0 0 2 2 2 0 Tetrabrachion MFS_1 PF07690.14 001127661.1_22424001_2 - 7.3e-16 57.9 13.9 3e-12 46.0 0.6 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.4 001127661.1_22424001_2 - 1.9e-11 43.1 5.0 1.9e-11 43.1 5.0 3.1 4 0 0 4 4 4 2 MFS/sugar transport protein Pkinase_Tyr PF07714.15 001319274.1_22429001_1 - 2.3e-78 262.9 0.0 3.3e-78 262.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.22 001319274.1_22429001_1 - 4.7e-62 206.9 0.3 6.4e-30 103.4 0.0 2.3 2 0 0 2 2 2 2 Receptor L domain GF_recep_IV PF14843.4 001319274.1_22429001_1 - 1.1e-52 177.2 79.0 5.2e-48 162.0 28.4 5.0 2 1 2 4 4 4 4 Growth factor receptor domain IV Furin-like PF00757.18 001319274.1_22429001_1 - 7.2e-36 123.2 84.6 1.4e-30 106.0 36.6 4.4 2 1 2 4 4 4 3 Furin-like cysteine rich region Pkinase PF00069.23 001319274.1_22429001_1 - 1.3e-32 113.1 0.0 1.9e-32 112.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.4 001319274.1_22429001_1 - 0.019 14.2 0.0 0.04 13.1 0.0 1.4 1 0 0 1 1 1 0 Kinase-like DUF4381 PF14316.4 001319274.1_22429001_1 - 0.053 13.6 0.0 0.095 12.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Folate_carrier PF01770.16 001039956.1_22428001_3 - 2.4e-174 579.8 24.4 3.2e-174 579.4 24.4 1.2 1 0 0 1 1 1 1 Reduced folate carrier MFS_1 PF07690.14 001039956.1_22428001_3 - 2.8e-08 33.0 30.8 2.8e-08 33.0 30.8 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily MHC_II_alpha PF00993.18 001128071.1_22423001_2 - 3e-36 122.8 0.1 4.3e-36 122.3 0.1 1.2 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001128071.1_22423001_2 - 3.6e-29 99.8 0.3 6.7e-29 98.9 0.3 1.5 1 0 0 1 1 1 1 C1-set C-terminal domain C1-set PF07654.13 001128071.1_22423001_2 - 7.7e-23 80.7 0.0 1.1e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001128071.1_22423001_2 - 0.00013 22.4 0.0 0.0002 21.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Marek_A PF02124.13 001128071.1_22423001_2 - 0.00068 19.4 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 Marek's disease glycoprotein A C2-set_2 PF08205.10 001128071.1_22423001_2 - 0.13 12.2 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.4 001128071.1_22423001_2 - 0.16 12.2 0.0 0.28 11.4 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin domain Cullin PF00888.20 001048152.1_22426001_1 - 8.9e-209 694.9 21.1 1.3e-208 694.4 21.1 1.3 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.7 001048152.1_22426001_1 - 1.1e-25 89.2 1.6 4.6e-25 87.3 1.6 2.2 1 0 0 1 1 1 1 Cullin protein neddylation domain SecA_SW PF07516.11 001048152.1_22426001_1 - 0.00021 21.3 1.3 0.00021 21.3 1.3 3.3 3 1 0 3 3 3 1 SecA Wing and Scaffold domain PG_binding_4 PF12229.6 001048152.1_22426001_1 - 0.33 11.1 2.9 1.5 9.0 0.1 3.3 3 0 0 3 3 3 0 Putative peptidoglycan binding domain DUF2935 PF11155.6 001048152.1_22426001_1 - 6 7.1 7.5 5.2 7.3 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF2935) CCDC85 PF10226.7 001048152.1_22426001_1 - 7.4 6.1 9.3 0.12 11.9 0.2 2.7 2 0 0 2 2 2 0 CCDC85 family Ald_Xan_dh_C2 PF02738.16 001290238.1_22428001_1 - 2.4e-185 617.0 0.0 3.2e-185 616.6 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 001290238.1_22428001_1 - 1.2e-45 155.2 0.0 3.2e-45 153.8 0.0 1.7 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.20 001290238.1_22428001_1 - 1.4e-32 112.1 0.3 2.7e-32 111.3 0.3 1.5 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.18 001290238.1_22428001_1 - 1.7e-29 101.5 0.3 4.1e-29 100.2 0.3 1.6 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.15 001290238.1_22428001_1 - 3.3e-28 97.7 0.0 5.2e-26 90.7 0.0 3.1 3 0 0 3 3 3 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.25 001290238.1_22428001_1 - 6.8e-08 32.2 0.1 6.8e-08 32.2 0.1 2.4 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain DHODB_Fe-S_bind PF10418.7 001290238.1_22428001_1 - 0.18 11.5 5.7 0.034 13.8 1.4 2.1 2 0 0 2 2 2 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B PAP2 PF01569.19 001128199.1_22429001_1 - 7.3e-16 58.1 0.3 1.3e-15 57.2 0.3 1.3 1 0 0 1 1 1 1 PAP2 superfamily NPC1_N PF16414.3 001009829.2_22429001_1 - 3.2e-83 278.9 8.4 6e-83 278.0 8.4 1.5 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Patched PF02460.16 001009829.2_22429001_1 - 2e-80 270.9 25.3 1.4e-49 168.8 1.6 2.1 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.6 001009829.2_22429001_1 - 2e-56 190.0 3.7 2e-56 190.0 3.7 2.6 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.13 001009829.2_22429001_1 - 4.7e-07 28.9 2.1 4.7e-07 28.9 2.1 2.5 2 1 0 2 2 2 1 MMPL family ACR_tran PF00873.17 001009829.2_22429001_1 - 0.0096 13.5 14.1 0.004 14.7 9.0 2.0 2 0 0 2 2 2 1 AcrB/AcrD/AcrF family Vault PF01505.16 001042562.1_22426001_1 - 1.9e-59 197.5 5.6 1.4e-15 57.2 0.0 5.3 5 0 0 5 5 5 4 Major Vault Protein repeat MVP_shoulder PF11978.6 001042562.1_22426001_1 - 9.3e-52 173.9 0.0 1.9e-51 172.9 0.0 1.6 1 0 0 1 1 1 1 Shoulder domain DUF3601 PF12208.6 001042562.1_22426001_1 - 0.0024 17.8 0.0 2.1 8.4 0.0 3.1 2 1 1 3 3 3 2 Domain of unknown function (DUF3601) DUF2543 PF10820.6 001042562.1_22426001_1 - 0.12 12.5 0.4 0.25 11.4 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2543) Transthyretin PF00576.19 001287556.1_22422001_1 - 2.1e-19 70.1 0.1 2.9e-19 69.7 0.1 1.1 1 0 0 1 1 1 1 HIUase/Transthyretin family Trefoil PF00088.16 001130389.1_22421001_3 - 8.7e-15 54.2 7.7 1.4e-14 53.6 7.7 1.3 1 0 0 1 1 1 1 Trefoil (P-type) domain SDF PF00375.16 001278844.1_22424001_1 - 1.2e-120 403.0 24.3 1.3e-120 402.8 24.3 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family 7tm_1 PF00001.19 001317359.1_22423001_3 - 3.6e-38 131.2 13.6 5e-38 130.7 13.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CBF_beta PF02312.15 001305028.1_22422001_1 - 3.2e-85 283.8 3.2 3.6e-85 283.6 3.2 1.0 1 0 0 1 1 1 1 Core binding factor beta subunit Ig_2 PF13895.4 001290240.1_22422001_1 - 7.4e-21 74.1 0.2 2.5e-10 40.4 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001290240.1_22422001_1 - 3.2e-16 59.6 0.1 2.4e-07 31.1 0.0 3.0 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.23 001290240.1_22422001_1 - 2.8e-10 40.1 1.5 9.6e-05 22.4 0.1 3.1 2 1 0 2 2 2 2 Immunoglobulin domain Ig_4 PF16680.3 001290240.1_22422001_1 - 2.5e-08 34.0 0.0 0.00013 22.1 0.0 2.4 2 0 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain I-set PF07679.14 001290240.1_22422001_1 - 1.1e-06 28.4 0.2 0.1 12.6 0.1 3.8 3 2 0 3 3 3 2 Immunoglobulin I-set domain Ig_5 PF16681.3 001290240.1_22422001_1 - 3.5e-05 24.0 0.0 0.0097 16.2 0.0 2.5 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set PF07686.15 001290240.1_22422001_1 - 0.00051 20.0 1.8 8.8 6.4 0.0 4.2 3 2 2 5 5 5 2 Immunoglobulin V-set domain Protocadherin PF08374.9 001290240.1_22422001_1 - 0.0059 16.5 0.2 0.011 15.6 0.2 1.3 1 0 0 1 1 1 1 Protocadherin DUF2681 PF10883.6 001290240.1_22422001_1 - 0.0095 16.2 0.6 0.015 15.5 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2681) PAP_PilO PF06864.10 001290240.1_22422001_1 - 0.012 14.5 0.1 0.018 13.9 0.1 1.2 1 0 0 1 1 1 0 Pilin accessory protein (PilO) DUF202 PF02656.13 001290240.1_22422001_1 - 0.047 14.0 0.2 0.079 13.3 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF202) DUF1049 PF06305.9 001290240.1_22422001_1 - 0.15 11.7 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Bcl-2 PF00452.17 001009228.1_22423001_2 - 2.6e-34 117.7 0.1 4.7e-34 116.8 0.1 1.5 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family BH4 PF02180.15 001009228.1_22423001_2 - 6.1e-14 51.3 0.4 1.1e-13 50.5 0.4 1.5 1 0 0 1 1 1 1 Bcl-2 homology region 4 Bcl-2_3 PF15286.4 001009228.1_22423001_2 - 0.042 14.4 0.0 0.061 13.9 0.0 1.2 1 0 0 1 1 1 0 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like Homeobox PF00046.27 001173442.1_22422001_1 - 1.8e-18 65.9 6.3 3.8e-18 64.9 6.3 1.5 1 0 0 1 1 1 1 Homeobox domain ASFV_J13L PF05568.9 001173442.1_22422001_2 - 1 9.0 4.2 1.5 8.4 4.2 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein SDF PF00375.16 001009334.1_22424001_1 - 1.8e-132 441.9 28.8 2.1e-132 441.7 28.8 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family DUF2209 PF09974.7 001009334.1_22424001_1 - 0.081 13.1 0.2 3.8 7.7 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2209) HlyIII PF03006.18 001134681.1_22423001_1 - 2.6e-72 243.0 19.4 3.1e-72 242.8 19.4 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF4405 PF14358.4 001134681.1_22423001_1 - 0.012 16.0 3.2 0.012 16.0 3.2 3.5 3 1 1 4 4 4 0 Domain of unknown function (DUF4405) DUF962 PF06127.9 001134681.1_22423001_1 - 0.023 14.6 1.2 0.023 14.6 1.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF962) ABC_membrane PF00664.21 001171064.2_22429001_3 - 1.7e-170 565.7 33.9 7.1e-93 311.1 12.4 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 001171064.2_22429001_3 - 2.9e-76 254.4 0.6 1.1e-36 126.3 0.1 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 001171064.2_22429001_3 - 8.2e-16 58.0 4.3 6.6e-07 28.9 0.3 3.8 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 001171064.2_22429001_3 - 3e-11 43.9 0.3 0.00025 21.3 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.7 001171064.2_22429001_3 - 1.6e-10 40.3 0.3 3.7e-05 22.6 0.0 2.9 3 0 0 3 3 3 2 Predicted ATPase of the ABC class Zeta_toxin PF06414.10 001171064.2_22429001_3 - 1.5e-08 34.1 1.1 0.0006 19.0 0.0 3.3 4 0 0 4 4 4 2 Zeta toxin DUF258 PF03193.14 001171064.2_22429001_3 - 2.5e-08 33.9 0.1 0.0059 16.4 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_22 PF13401.4 001171064.2_22429001_3 - 4.4e-08 33.4 1.0 0.0098 16.0 0.1 3.2 2 2 0 2 2 2 2 AAA domain G-alpha PF00503.18 001171064.2_22429001_3 - 2.8e-07 29.9 0.0 0.0032 16.5 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit Rad17 PF03215.13 001171064.2_22429001_3 - 1.9e-06 27.0 0.1 0.0082 15.0 0.1 2.3 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_29 PF13555.4 001171064.2_22429001_3 - 4.5e-06 26.2 1.5 0.05 13.2 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA PF00004.27 001171064.2_22429001_3 - 6.6e-06 26.4 3.6 0.16 12.3 0.2 4.2 2 2 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.12 001171064.2_22429001_3 - 2.7e-05 24.1 2.0 0.31 10.9 0.1 3.7 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) SbcCD_C PF13558.4 001171064.2_22429001_3 - 0.0001 22.4 3.7 0.17 12.0 0.4 3.7 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit APS_kinase PF01583.18 001171064.2_22429001_3 - 0.00023 21.0 0.2 0.85 9.4 0.0 2.5 2 0 0 2 2 2 2 Adenylylsulphate kinase DUF815 PF05673.11 001171064.2_22429001_3 - 0.00038 19.6 0.2 0.32 10.0 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_15 PF13175.4 001171064.2_22429001_3 - 0.00043 19.9 0.0 0.38 10.2 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain PRK PF00485.16 001171064.2_22429001_3 - 0.00055 19.6 0.1 0.61 9.7 0.0 2.6 2 1 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family DUF87 PF01935.15 001171064.2_22429001_3 - 0.00064 19.7 2.2 0.4 10.6 0.0 3.0 4 0 0 4 4 2 2 Domain of unknown function DUF87 RNA_helicase PF00910.20 001171064.2_22429001_3 - 0.0019 18.4 0.0 4.7 7.5 0.0 3.0 3 0 0 3 3 2 0 RNA helicase AAA_30 PF13604.4 001171064.2_22429001_3 - 0.0019 17.8 2.7 0.41 10.2 0.2 3.1 2 1 0 2 2 2 1 AAA domain ATP-synt_ab PF00006.23 001171064.2_22429001_3 - 0.002 17.7 1.2 1.8 8.1 0.0 3.0 2 1 0 3 3 3 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_21 PF13304.4 001171064.2_22429001_3 - 0.0025 17.6 0.0 9.7 5.8 0.0 4.2 3 1 1 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_24 PF13479.4 001171064.2_22429001_3 - 0.0027 17.3 0.0 0.88 9.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.4 001171064.2_22429001_3 - 0.0042 17.2 0.1 5 7.2 0.1 3.1 2 1 1 3 3 3 0 AAA domain IstB_IS21 PF01695.15 001171064.2_22429001_3 - 0.0089 15.7 1.7 22 4.7 0.0 4.0 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_33 PF13671.4 001171064.2_22429001_3 - 0.011 15.7 0.5 5.2 7.1 0.0 2.8 2 1 0 2 2 2 0 AAA domain tRNA_lig_kinase PF08303.9 001171064.2_22429001_3 - 0.023 14.7 0.0 8.1 6.4 0.0 2.5 2 0 0 2 2 2 0 tRNA ligase kinase domain AAA_18 PF13238.4 001171064.2_22429001_3 - 0.025 15.0 0.0 5.8 7.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain NACHT PF05729.10 001171064.2_22429001_3 - 0.026 14.3 0.1 7.2 6.4 0.0 2.4 2 0 0 2 2 2 0 NACHT domain DUF2207 PF09972.7 001171064.2_22429001_3 - 0.036 12.7 0.0 0.036 12.7 0.0 3.6 4 0 0 4 4 4 0 Predicted membrane protein (DUF2207) AAA_25 PF13481.4 001171064.2_22429001_3 - 0.043 13.3 0.1 7.2 6.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.13 001171064.2_22429001_3 - 0.05 13.4 0.6 1.3 8.7 0.1 2.8 3 0 0 3 3 2 0 NTPase NB-ARC PF00931.20 001171064.2_22429001_3 - 0.099 11.5 1.0 8.8 5.1 0.1 2.3 2 0 0 2 2 2 0 NB-ARC domain PduV-EutP PF10662.7 001171064.2_22429001_3 - 0.15 11.7 2.6 26 4.4 0.0 3.7 4 0 0 4 4 3 0 Ethanolamine utilisation - propanediol utilisation CLTH PF10607.7 001134988.1_22424001_1 - 2.4e-48 163.6 0.0 3.5e-48 163.1 0.0 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain SPRY PF00622.26 001134988.1_22424001_1 - 7.3e-26 90.5 0.2 7.3e-26 90.5 0.2 1.8 2 0 0 2 2 2 1 SPRY domain LisH PF08513.9 001134988.1_22424001_1 - 7.9e-05 22.4 0.0 0.0002 21.1 0.0 1.7 1 0 0 1 1 1 1 LisH SOG2 PF10428.7 001134988.1_22424001_1 - 0.059 12.5 14.1 0.074 12.2 14.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein SPX PF03105.17 001134988.1_22424001_1 - 0.11 12.3 14.1 0.19 11.5 14.1 1.4 1 0 0 1 1 1 0 SPX domain PRCC PF10253.7 001134988.1_22424001_1 - 1.9 9.1 14.3 3.9 8.1 14.3 1.5 1 1 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Macoilin PF09726.7 001134988.1_22424001_1 - 2.3 6.5 11.5 3 6.2 11.5 1.1 1 0 0 1 1 1 0 Transmembrane protein Hid1 PF12722.5 001134988.1_22424001_1 - 2.7 5.9 7.9 4.1 5.2 7.9 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Apt1 PF10351.7 001134988.1_22424001_1 - 9.7 4.8 14.6 16 4.1 14.6 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain 7tm_1 PF00001.19 001009861.1_22423001_1 - 7.5e-18 64.6 13.3 7.5e-18 64.6 13.3 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Serpentine_r_xa PF03383.13 001009861.1_22423001_1 - 4.3e-05 23.4 1.7 4.3e-05 23.4 1.7 2.7 2 1 1 3 3 3 1 Caenorhabditis serpentine receptor-like protein, class xa 7TM_GPCR_Srv PF10323.7 001009861.1_22423001_1 - 0.0013 18.0 14.2 0.0014 17.9 12.5 1.9 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv RPA PF10134.7 001009861.1_22423001_1 - 0.14 11.5 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Replication initiator protein A NPCC PF08058.9 001009861.1_22423001_1 - 2.8 7.9 8.2 64 3.5 4.1 3.2 2 1 0 2 2 2 0 Nuclear pore complex component Folate_carrier PF01770.16 001278820.1_22426001_2 - 1.6e-176 587.0 22.9 2e-176 586.6 22.9 1.1 1 0 0 1 1 1 1 Reduced folate carrier MFS_1 PF07690.14 001278820.1_22426001_2 - 8e-10 38.0 23.9 8e-10 38.0 23.9 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily ThiF PF00899.19 001278841.1_22427001_1 - 4.4e-104 347.0 0.0 1.1e-70 237.6 0.0 2.1 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.7 001278841.1_22427001_1 - 1.6e-72 244.4 0.0 2.2e-72 243.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.3 001278841.1_22427001_1 - 3.9e-23 81.3 0.0 7.2e-23 80.5 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_UFD PF09358.8 001278841.1_22427001_1 - 3.9e-23 81.8 0.0 7.9e-23 80.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin fold domain E1_4HB PF16191.3 001278841.1_22427001_1 - 5.1e-18 64.9 0.3 2.4e-17 62.7 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 four-helix bundle NAD_binding_7 PF13241.4 001278841.1_22427001_1 - 0.077 13.3 0.0 4.1 7.8 0.0 2.9 2 0 0 2 2 2 0 Putative NAD(P)-binding V-set PF07686.15 001009236.1_22424001_3 - 2.7e-08 33.8 0.0 4.2e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain V-set_2 PF15910.3 001009236.1_22424001_3 - 0.0022 18.0 0.0 0.004 17.1 0.0 1.4 1 0 0 1 1 1 1 ICOS V-set domain Ig_3 PF13927.4 001009236.1_22424001_3 - 0.065 13.7 0.1 0.13 12.8 0.1 1.4 1 0 0 1 1 1 0 Immunoglobulin domain 7tm_1 PF00001.19 001287228.1_22422001_1 - 6.5e-40 136.9 11.4 6.5e-40 136.9 11.4 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3307 PF11750.6 001287228.1_22422001_1 - 0.35 10.8 5.4 0.072 13.0 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3307) Sulfate_transp PF00916.18 001137656.1_22425001_1 - 4.9e-107 357.8 19.8 6.8e-107 357.4 19.8 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.19 001137656.1_22425001_1 - 1.3e-24 85.9 0.0 2.4e-24 85.1 0.0 1.5 1 0 0 1 1 1 1 STAS domain DUF2755 PF10954.6 001137656.1_22425001_1 - 0.58 10.0 3.1 0.55 10.0 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2755) MHC_II_alpha PF00993.18 001309051.1_22422001_1 - 2.1e-36 123.3 0.1 3e-36 122.8 0.1 1.2 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001309051.1_22422001_1 - 2.8e-29 100.1 0.3 6.2e-29 99.0 0.3 1.6 1 0 0 1 1 1 1 C1-set C-terminal domain C1-set PF07654.13 001309051.1_22422001_1 - 4.9e-23 81.3 0.0 7.9e-23 80.6 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001309051.1_22422001_1 - 0.00011 22.7 0.0 0.00017 22.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Marek_A PF02124.13 001309051.1_22422001_1 - 0.00062 19.5 0.0 0.001 18.8 0.0 1.3 1 0 0 1 1 1 1 Marek's disease glycoprotein A DUF751 PF05421.9 001309051.1_22422001_1 - 0.042 14.4 1.4 0.63 10.6 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF751) C2-set_2 PF08205.10 001309051.1_22422001_1 - 0.099 12.6 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Ly49 PF08391.8 001009834.1_22422001_1 - 1.4e-45 154.3 8.3 2.5e-45 153.5 8.3 1.4 1 0 0 1 1 1 1 Ly49-like protein, N-terminal region Lectin_C PF00059.19 001009834.1_22422001_1 - 4e-18 66.0 4.9 4e-18 66.0 4.9 1.8 2 0 0 2 2 2 1 Lectin C-type domain DUF3139 PF11337.6 001009834.1_22422001_1 - 0.0011 19.4 0.2 0.003 18.0 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3139) Lectin_N PF03954.12 001009834.1_22422001_1 - 0.0036 16.9 0.2 0.0053 16.4 0.2 1.2 1 0 0 1 1 1 1 Hepatic lectin, N-terminal domain Stig1 PF04885.11 001009834.1_22422001_1 - 0.017 15.5 5.0 0.017 15.5 5.0 1.5 2 0 0 2 2 2 0 Stigma-specific protein, Stig1 MFS_Mycoplasma PF07672.11 001009834.1_22422001_1 - 0.049 12.8 0.2 0.076 12.1 0.2 1.2 1 0 0 1 1 1 0 Mycoplasma MFS transporter CdCA1 PF10563.7 001009834.1_22422001_1 - 0.052 13.1 3.2 0.32 10.6 1.1 2.1 1 1 1 2 2 2 0 Cadmium carbonic anhydrase repeat MAP17 PF15807.3 001009834.1_22422001_1 - 0.069 13.2 0.2 0.11 12.6 0.2 1.2 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Vpu PF00558.17 001009834.1_22422001_1 - 0.087 12.5 0.2 0.2 11.3 0.2 1.6 1 0 0 1 1 1 0 Vpu protein CD20 PF04103.13 001009834.1_22422001_1 - 0.15 12.0 1.4 0.47 10.4 0.0 2.1 2 0 0 2 2 2 0 CD20-like family Tetraspannin PF00335.18 001009834.1_22422001_1 - 6.6 6.4 14.8 11 5.7 14.7 1.5 1 1 0 1 1 1 0 Tetraspanin family SDF PF00375.16 001290234.1_22424001_1 - 1.5e-120 402.7 23.6 1.7e-120 402.5 23.6 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family Troponin PF00992.18 001009347.1_22422001_1 - 1.6e-36 125.4 50.4 4.7e-32 111.0 36.8 3.1 2 1 1 3 3 3 2 Troponin IL8 PF00048.18 001163657.1_22421001_1 - 7.2e-25 86.8 0.3 8.9e-25 86.5 0.3 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like IL8 PF00048.18 001163658.1_22421001_1 - 1.8e-23 82.3 0.1 2.3e-23 82.0 0.1 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Glyco_hydro_20 PF00728.20 001278835.1_22424001_1 - 6.3e-85 285.5 0.0 1.1e-84 284.7 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.4 001278835.1_22424001_1 - 7.5e-21 75.1 0.0 1.2e-20 74.3 0.0 1.4 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.13 001278835.1_22424001_1 - 0.067 13.9 0.0 0.14 12.8 0.0 1.6 1 1 0 1 1 1 0 Glycosyl hydrolase family 20, domain 2 Pro_isomerase PF00160.19 001278861.1_22422001_1 - 1e-48 165.5 0.0 1.2e-48 165.3 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Tubulin-binding PF00418.17 001164033.2_22427001_1 - 7.8e-55 182.4 28.3 5.3e-15 55.0 6.2 4.6 4 0 0 4 4 4 4 Tau and MAP protein, tubulin-binding repeat GM_CSF PF01109.15 001309037.1_22421001_1 - 1e-65 219.3 0.3 1.2e-65 219.1 0.3 1.0 1 0 0 1 1 1 1 Granulocyte-macrophage colony-stimulating factor DUF1722 PF08349.9 001309037.1_22421001_1 - 0.0032 17.6 0.0 0.0048 17.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1722) FYVE_2 PF02318.14 001079655.1_22424001_1 - 4.4e-49 165.5 3.1 8.6e-49 164.5 3.1 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger Rab_eff_C PF04698.10 001079655.1_22424001_1 - 3.9e-12 45.2 4.5 3.2e-09 35.6 0.0 2.2 2 0 0 2 2 2 2 Rab effector MyRIP/melanophilin C-terminus End3 PF12761.5 001079655.1_22424001_1 - 0.18 11.8 4.5 0.83 9.7 1.3 2.4 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 DUF16 PF01519.14 001079655.1_22424001_1 - 0.46 10.9 0.1 0.46 10.9 0.1 1.9 3 0 0 3 3 3 0 Protein of unknown function DUF16 zf-piccolo PF05715.11 001079655.1_22424001_1 - 2.1 8.4 7.4 4.8 7.3 7.4 1.7 1 1 0 1 1 1 0 Piccolo Zn-finger TGF_beta PF00019.18 001165900.1_22423001_1 - 2.6e-27 95.6 0.2 5.8e-27 94.5 0.2 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.16 001165900.1_22423001_1 - 0.16 11.6 0.0 0.39 10.3 0.0 1.7 1 1 0 1 1 1 0 TGF-beta propeptide PAD PF03068.13 001079697.2_22425001_3 - 2.3e-150 500.8 0.0 3.1e-150 500.4 0.0 1.1 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) PAD_M PF08527.8 001079697.2_22425001_3 - 2.1e-57 193.1 0.0 3.6e-57 192.3 0.0 1.4 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) middle domain PAD_N PF08526.8 001079697.2_22425001_3 - 5.6e-43 145.8 0.0 1.2e-42 144.7 0.0 1.6 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) N-terminal domain Retrotrans_gag PF03732.15 001291090.1_22426001_1 - 2.7e-16 59.5 2.4 3.7e-15 55.8 0.1 2.4 2 0 0 2 2 2 1 Retrotransposon gag protein DUF4939 PF16297.3 001291090.1_22426001_1 - 2.2e-15 56.3 0.0 4e-15 55.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Rootletin PF15035.4 001291090.1_22426001_1 - 8.9e-05 22.5 1.1 0.00018 21.5 1.1 1.4 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion KASH_CCD PF14662.4 001291090.1_22426001_1 - 0.00013 21.7 2.9 0.00023 20.9 2.9 1.3 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH CASP_C PF08172.10 001291090.1_22426001_1 - 0.00099 18.4 0.0 0.0015 17.8 0.0 1.2 1 0 0 1 1 1 1 CASP C terminal zf-CCHC_5 PF14787.4 001291090.1_22426001_1 - 0.0018 17.8 0.2 0.0018 17.8 0.2 1.9 2 0 0 2 2 1 1 GAG-polyprotein viral zinc-finger SR-25 PF10500.7 001291090.1_22426001_1 - 0.0049 16.4 5.8 0.0049 16.4 5.8 2.1 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Uso1_p115_C PF04871.11 001291090.1_22426001_1 - 0.029 14.6 2.7 0.049 13.9 2.7 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Spc7 PF08317.9 001291090.1_22426001_1 - 0.039 12.7 3.3 0.079 11.7 3.3 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein zf-CCHC PF00098.21 001291090.1_22426001_1 - 0.044 13.7 2.2 0.13 12.2 2.2 1.9 1 0 0 1 1 1 0 Zinc knuckle ZapB PF06005.10 001291090.1_22426001_1 - 0.059 13.7 8.3 0.17 12.3 8.3 1.7 1 0 0 1 1 1 0 Cell division protein ZapB DUF972 PF06156.11 001291090.1_22426001_1 - 0.064 13.8 2.9 0.19 12.2 2.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF972) SHE3 PF17078.3 001291090.1_22426001_1 - 0.082 12.5 6.0 0.036 13.6 3.4 1.6 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 CENP-H PF05837.10 001291090.1_22426001_1 - 0.1 12.9 5.5 0.29 11.4 5.5 1.7 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF1664 PF07889.10 001291090.1_22426001_1 - 0.1 12.4 0.4 0.23 11.3 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) V_ATPase_I PF01496.17 001291090.1_22426001_1 - 0.12 10.1 0.4 0.16 9.7 0.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family IncA PF04156.12 001291090.1_22426001_1 - 0.16 11.6 6.7 0.3 10.7 6.7 1.4 1 0 0 1 1 1 0 IncA protein TolA_bind_tri PF16331.3 001291090.1_22426001_1 - 0.17 11.9 4.9 0.36 10.8 4.9 1.5 1 0 0 1 1 1 0 TolA binding protein trimerisation eIF3g PF12353.6 001291090.1_22426001_1 - 0.2 11.9 0.1 0.2 11.9 0.1 1.7 2 0 0 2 2 1 0 Eukaryotic translation initiation factor 3 subunit G TMF_DNA_bd PF12329.6 001291090.1_22426001_1 - 0.24 11.3 6.5 0.47 10.4 6.5 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF3450 PF11932.6 001291090.1_22426001_1 - 0.25 10.5 3.8 0.45 9.6 3.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Prominin PF05478.9 001291090.1_22426001_1 - 0.38 8.5 0.8 0.6 7.9 0.8 1.1 1 0 0 1 1 1 0 Prominin SlyX PF04102.10 001291090.1_22426001_1 - 0.7 10.4 5.6 2.5 8.7 5.6 1.9 1 0 0 1 1 1 0 SlyX FlxA PF14282.4 001291090.1_22426001_1 - 1.1 9.1 8.8 3.4 7.6 8.7 1.7 1 1 0 1 1 1 0 FlxA-like protein GIT_CC PF16559.3 001291090.1_22426001_1 - 1.6 8.7 8.6 5.3 7.0 8.6 1.8 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor RCDG1 PF15725.3 001291090.1_22426001_1 - 3 8.2 11.7 9.6 6.6 11.7 1.9 1 0 0 1 1 1 0 Renal cancer differentiation gene 1 protein APG6 PF04111.10 001291090.1_22426001_1 - 3.7 6.7 6.2 1.2 8.3 3.3 1.5 2 0 0 2 2 2 0 Autophagy protein Apg6 TSC22 PF01166.16 001291090.1_22426001_1 - 4.9 7.4 7.5 31 4.9 7.5 2.0 1 1 0 1 1 1 0 TSC-22/dip/bun family HALZ PF02183.16 001291090.1_22426001_1 - 5.6 7.1 5.9 11 6.2 3.8 2.2 1 1 1 2 2 2 0 Homeobox associated leucine zipper XhlA PF10779.7 001291090.1_22426001_1 - 9.4 6.4 6.2 17 5.5 6.2 1.4 1 0 0 1 1 1 0 Haemolysin XhlA Asp_protease_2 PF13650.4 001291090.1_22426001_3 - 0.00015 22.2 0.0 0.00025 21.5 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001291090.1_22426001_3 - 0.0037 17.1 0.0 0.0062 16.4 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001291090.1_22426001_3 - 0.016 15.6 0.0 0.027 14.9 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp PF00026.21 001009868.1_22423001_3 - 3.3e-116 388.0 0.0 4e-116 387.7 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001009868.1_22423001_3 - 2.9e-15 56.9 0.3 8.5e-12 45.6 0.3 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001009868.1_22423001_3 - 1.4e-11 43.8 0.7 2.6e-11 43.0 0.7 1.4 1 0 0 1 1 1 1 A1 Propeptide Hexokinase_2 PF03727.14 001083954.1_22423001_1 - 1e-82 277.0 0.0 1.5e-82 276.5 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.19 001083954.1_22423001_1 - 2.4e-70 236.4 0.0 3.1e-70 236.1 0.0 1.2 1 0 0 1 1 1 1 Hexokinase SLAM PF06214.9 001278826.1_22423001_1 - 1.4e-63 212.3 0.8 2.2e-63 211.8 0.8 1.3 1 0 0 1 1 1 1 Signaling lymphocytic activation molecule (SLAM) protein Ig_3 PF13927.4 001278826.1_22423001_1 - 0.00053 20.4 1.4 0.0028 18.1 0.6 2.3 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 001278826.1_22423001_1 - 0.054 13.7 0.3 0.14 12.4 0.3 1.7 1 0 0 1 1 1 0 Immunoglobulin domain ETF PF01012.19 001287554.1_22423001_3 - 2.6e-41 141.4 1.2 3.7e-41 140.9 1.2 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.17 001287554.1_22423001_3 - 7.3e-37 125.1 0.2 1.5e-36 124.1 0.2 1.6 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain TNFR_c6 PF00020.16 001009361.1_22425001_2 - 8.3e-19 67.6 53.8 7.1e-09 35.8 7.9 4.6 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region Death PF00531.20 001009361.1_22425001_2 - 8.9e-18 64.1 0.0 1.6e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 Death domain Methyltransf_3 PF01596.15 001282066.1_22422001_1 - 3e-14 52.6 0.0 4e-14 52.2 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.4 001282066.1_22422001_1 - 7.6e-12 46.1 0.0 1.5e-11 45.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.17 001282066.1_22422001_1 - 0.0026 17.4 0.0 0.0035 17.0 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.4 001282066.1_22422001_1 - 0.022 14.4 0.0 0.035 13.8 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain GCD14 PF08704.8 001282066.1_22422001_1 - 0.035 13.7 0.0 0.048 13.2 0.0 1.1 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_25 PF13649.4 001282066.1_22422001_1 - 0.097 13.3 0.0 0.18 12.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Ig_3 PF13927.4 001290244.1_22425001_2 - 2.3e-10 40.8 0.1 0.00014 22.3 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001290244.1_22425001_2 - 5.3e-09 36.2 0.1 0.00068 19.8 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001290244.1_22425001_2 - 5e-07 29.6 0.0 0.003 17.4 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain C2-set_2 PF08205.10 001290244.1_22425001_2 - 7e-05 22.7 0.3 0.00018 21.4 0.1 1.7 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001290244.1_22425001_2 - 0.0014 18.6 0.1 0.92 9.6 0.0 2.9 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 001290244.1_22425001_2 - 0.012 15.6 0.0 0.11 12.5 0.0 2.3 1 1 0 1 1 1 0 Immunoglobulin V-set domain Filament PF00038.19 001290235.1_22424001_1 - 1.2e-105 353.4 32.8 1.4e-105 353.2 32.8 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001290235.1_22424001_1 - 4.8e-22 78.7 47.6 2e-17 63.7 4.1 3.2 2 1 1 3 3 3 2 Keratin type II head CENP-F_leu_zip PF10473.7 001290235.1_22424001_1 - 1.6e-06 28.0 29.8 0.0023 17.8 8.0 3.4 2 2 1 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 JIP_LZII PF16471.3 001290235.1_22424001_1 - 0.00087 19.3 17.8 0.73 9.9 0.2 5.4 3 1 2 5 5 5 2 JNK-interacting protein leucine zipper II Alanine_zipper PF11839.6 001290235.1_22424001_1 - 0.001 19.2 2.1 0.004 17.3 2.1 2.0 1 0 0 1 1 1 1 Alanine-zipper, major outer membrane lipoprotein Reo_sigmaC PF04582.10 001290235.1_22424001_1 - 0.0015 17.9 9.2 0.0084 15.4 1.8 2.6 1 1 2 3 3 3 2 Reovirus sigma C capsid protein Spc7 PF08317.9 001290235.1_22424001_1 - 0.0018 17.1 33.6 0.0053 15.6 9.7 3.1 1 1 3 4 4 4 4 Spc7 kinetochore protein TPR_MLP1_2 PF07926.10 001290235.1_22424001_1 - 0.0019 18.1 34.4 0.0034 17.3 1.2 4.4 1 1 4 5 5 5 2 TPR/MLP1/MLP2-like protein ADIP PF11559.6 001290235.1_22424001_1 - 0.0033 17.4 7.0 0.0033 17.4 7.0 3.4 2 2 0 2 2 2 1 Afadin- and alpha -actinin-Binding DUF4407 PF14362.4 001290235.1_22424001_1 - 0.02 14.1 15.1 0.23 10.6 0.9 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF5082 PF16888.3 001290235.1_22424001_1 - 0.027 14.7 21.1 0.078 13.2 0.8 3.9 3 1 1 4 4 4 0 Domain of unknown function (DUF5082) She9_MDM33 PF05546.9 001290235.1_22424001_1 - 0.037 13.7 7.6 1.4 8.6 0.2 2.8 2 1 0 2 2 2 0 She9 / Mdm33 family DUF1664 PF07889.10 001290235.1_22424001_1 - 0.11 12.4 18.1 0.51 10.2 1.2 4.3 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) Rootletin PF15035.4 001290235.1_22424001_1 - 0.11 12.5 21.5 0.067 13.1 5.3 2.7 2 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Baculo_PEP_C PF04513.10 001290235.1_22424001_1 - 0.2 11.5 14.0 0.38 10.7 1.1 3.6 1 1 4 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fez1 PF06818.13 001290235.1_22424001_1 - 0.23 11.8 25.6 0.082 13.2 10.6 2.5 1 1 1 2 2 2 0 Fez1 V_ATPase_I PF01496.17 001290235.1_22424001_1 - 0.27 8.9 15.4 0.04 11.7 2.2 2.2 2 1 0 2 2 2 0 V-type ATPase 116kDa subunit family FPP PF05911.9 001290235.1_22424001_1 - 0.49 8.4 27.5 0.56 8.3 12.5 2.2 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil Virulence_fact PF13769.4 001290235.1_22424001_1 - 0.69 10.0 0.1 0.69 10.0 0.1 3.2 3 1 0 4 4 3 0 Virulence factor DUF4094 PF13334.4 001290235.1_22424001_1 - 0.73 10.1 6.1 0.15 12.3 1.2 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) LPP PF04728.11 001290235.1_22424001_1 - 0.83 9.9 9.0 45 4.4 3.6 4.8 4 1 0 4 4 4 0 Lipoprotein leucine-zipper TMF_TATA_bd PF12325.6 001290235.1_22424001_1 - 1.7 8.8 27.1 5.2 7.2 0.1 5.0 2 2 2 5 5 5 0 TATA element modulatory factor 1 TATA binding Syntaxin-6_N PF09177.9 001290235.1_22424001_1 - 2 8.9 14.8 0.13 12.7 2.9 3.5 1 1 2 3 3 3 0 Syntaxin 6, N-terminal Laminin_II PF06009.10 001290235.1_22424001_1 - 2.2 8.1 18.0 1.4 8.8 2.3 3.5 1 1 2 4 4 4 0 Laminin Domain II COMP PF11598.6 001290235.1_22424001_1 - 2.3 8.6 6.5 59 4.1 0.1 3.7 3 0 0 3 3 3 0 Cartilage oligomeric matrix protein DUF883 PF05957.11 001290235.1_22424001_1 - 2.3 8.7 15.6 1.1 9.7 5.2 3.9 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF883) APG6 PF04111.10 001290235.1_22424001_1 - 2.5 7.3 30.0 3 7.0 13.4 2.9 1 1 2 3 3 3 0 Autophagy protein Apg6 bZIP_1 PF00170.19 001290235.1_22424001_1 - 2.5 8.1 20.7 0.6 10.1 0.6 5.4 5 1 0 5 5 5 0 bZIP transcription factor DUF4164 PF13747.4 001290235.1_22424001_1 - 2.6 8.2 20.9 2.7 8.2 1.7 4.3 2 2 2 4 4 3 0 Domain of unknown function (DUF4164) Jnk-SapK_ap_N PF09744.7 001290235.1_22424001_1 - 2.7 8.1 29.3 0.35 10.9 2.0 3.7 1 1 2 4 4 4 0 JNK_SAPK-associated protein-1 Ribosomal_S30AE PF02482.17 001290235.1_22424001_1 - 3.1 8.5 7.0 0.36 11.5 1.0 2.5 2 1 2 4 4 2 0 Sigma 54 modulation protein / S30EA ribosomal protein DUF342 PF03961.11 001290235.1_22424001_1 - 3.1 6.2 20.8 1.3 7.4 7.6 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF342) DUF4140 PF13600.4 001290235.1_22424001_1 - 4.1 7.8 22.1 1.9 8.8 1.3 4.9 3 2 2 5 5 5 0 N-terminal domain of unknown function (DUF4140) Cob_adeno_trans PF01923.16 001290235.1_22424001_1 - 4.6 7.2 8.9 13 5.7 5.7 3.0 1 1 2 3 3 3 0 Cobalamin adenosyltransferase DUF972 PF06156.11 001290235.1_22424001_1 - 5.2 7.6 26.1 0.55 10.8 1.3 4.8 2 2 3 5 5 5 0 Protein of unknown function (DUF972) TMF_DNA_bd PF12329.6 001290235.1_22424001_1 - 5.5 6.9 27.1 2.4 8.1 1.6 4.7 3 2 1 4 4 4 0 TATA element modulatory factor 1 DNA binding TraC PF07820.10 001290235.1_22424001_1 - 7.6 6.8 8.5 1.4 9.1 2.5 2.8 3 0 0 3 3 2 0 TraC-like protein Flt3_lig PF02947.12 001009842.1_22422001_1 - 1.2e-66 222.7 0.7 1.5e-66 222.4 0.7 1.1 1 0 0 1 1 1 1 flt3 ligand UPF0004 PF00919.18 001278832.1_22426001_2 - 4e-21 74.8 0.0 7.6e-21 73.9 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 Radical_SAM PF04055.19 001278832.1_22426001_2 - 7.3e-18 65.4 0.1 1.4e-17 64.4 0.1 1.5 1 0 0 1 1 1 1 Radical SAM superfamily TRAM PF01938.18 001278832.1_22426001_2 - 0.0016 18.2 0.0 0.0027 17.5 0.0 1.4 1 0 0 1 1 1 1 TRAM domain YdaT_toxin PF06254.9 001278832.1_22426001_2 - 0.072 13.3 0.0 0.27 11.5 0.0 1.9 2 0 0 2 2 2 0 Putative bacterial toxin ydaT SAA PF00277.16 001309040.1_22421001_1 - 5.4e-51 171.2 6.3 6.2e-51 171.0 6.3 1.0 1 0 0 1 1 1 1 Serum amyloid A protein Filament PF00038.19 001278857.1_22424001_1 - 8e-104 347.4 34.3 9.4e-104 347.2 34.3 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001278857.1_22424001_1 - 1.1e-22 80.9 21.6 1.1e-22 80.9 21.6 3.0 2 1 0 2 2 2 1 Keratin type II head CENP-F_leu_zip PF10473.7 001278857.1_22424001_1 - 2.9e-05 24.0 27.7 0.0044 16.9 6.6 3.6 2 2 2 4 4 4 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.10 001278857.1_22424001_1 - 0.0059 16.5 0.4 0.0059 16.5 0.4 3.9 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein Reo_sigmaC PF04582.10 001278857.1_22424001_1 - 0.011 15.0 5.4 0.058 12.7 0.3 2.3 1 1 0 2 2 2 0 Reovirus sigma C capsid protein Baculo_PEP_C PF04513.10 001278857.1_22424001_1 - 0.013 15.4 0.7 0.013 15.4 0.7 4.1 2 2 3 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.9 001278857.1_22424001_1 - 0.021 13.6 33.1 0.034 12.9 6.3 3.4 1 1 3 4 4 4 0 Spc7 kinetochore protein DUF4407 PF14362.4 001278857.1_22424001_1 - 0.028 13.6 18.7 0.2 10.8 0.4 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) NPV_P10 PF05531.10 001278857.1_22424001_1 - 0.036 14.4 12.2 0.29 11.5 0.2 4.1 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein Ribosomal_S30AE PF02482.17 001278857.1_22424001_1 - 0.062 14.0 0.9 0.062 14.0 0.9 2.8 2 1 0 2 2 2 0 Sigma 54 modulation protein / S30EA ribosomal protein DUF1664 PF07889.10 001278857.1_22424001_1 - 0.083 12.7 18.9 0.22 11.4 1.3 4.3 3 1 2 5 5 5 0 Protein of unknown function (DUF1664) ACCA PF03255.12 001278857.1_22424001_1 - 0.24 11.1 13.8 0.38 10.5 0.2 3.5 2 1 2 4 4 4 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DUF5082 PF16888.3 001278857.1_22424001_1 - 0.26 11.5 24.0 0.11 12.7 2.1 4.6 2 2 3 5 5 5 0 Domain of unknown function (DUF5082) ADIP PF11559.6 001278857.1_22424001_1 - 0.27 11.2 26.3 0.057 13.4 6.7 3.7 2 2 2 4 4 4 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.9 001278857.1_22424001_1 - 1.5 8.8 29.2 0.089 12.8 12.0 4.1 1 1 2 4 4 4 0 Autophagy protein 16 (ATG16) Jnk-SapK_ap_N PF09744.7 001278857.1_22424001_1 - 1.6 8.8 27.8 0.046 13.8 1.2 3.5 2 1 0 3 3 3 0 JNK_SAPK-associated protein-1 Alanine_zipper PF11839.6 001278857.1_22424001_1 - 1.7 8.9 11.6 0.21 11.7 6.0 2.3 2 1 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein FlaC_arch PF05377.9 001278857.1_22424001_1 - 2.2 8.6 14.3 21 5.4 0.1 5.8 5 2 2 7 7 7 0 Flagella accessory protein C (FlaC) IncA PF04156.12 001278857.1_22424001_1 - 2.6 7.6 32.2 25 4.5 16.3 3.5 1 1 1 2 2 2 0 IncA protein DUF342 PF03961.11 001278857.1_22424001_1 - 3.8 5.9 19.2 0.64 8.4 3.4 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF342) JIP_LZII PF16471.3 001278857.1_22424001_1 - 4.4 7.4 18.3 14 5.8 0.2 5.4 4 1 1 5 5 5 0 JNK-interacting protein leucine zipper II DUF948 PF06103.9 001278857.1_22424001_1 - 6.5 7.0 6.0 7 6.9 0.4 3.3 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF948) Syntaxin-6_N PF09177.9 001278857.1_22424001_1 - 8.1 6.9 13.3 80 3.8 7.7 3.5 1 1 2 3 3 3 0 Syntaxin 6, N-terminal MHC_II_beta PF00969.17 001309039.1_22422001_1 - 3.4e-35 119.9 0.6 5.1e-35 119.3 0.6 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001309039.1_22422001_1 - 1.4e-26 92.6 0.7 4.8e-26 90.9 0.2 2.0 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001309039.1_22422001_1 - 8e-06 26.2 0.1 3.2e-05 24.3 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001309039.1_22422001_1 - 0.00037 20.5 0.2 0.00079 19.4 0.2 1.6 1 0 0 1 1 1 1 Immunoglobulin domain DUF202 PF02656.13 001309039.1_22422001_1 - 0.012 15.9 0.0 0.023 15.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) MHC_I PF00129.16 001309039.1_22422001_1 - 0.043 13.2 0.0 0.07 12.6 0.0 1.3 1 0 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 CSD PF00313.20 001173445.1_22422001_1 - 8.8e-17 60.6 0.3 2.4e-16 59.2 0.3 1.7 1 1 0 1 1 1 1 'Cold-shock' DNA-binding domain zf-CCHC PF00098.21 001173445.1_22422001_1 - 6.5e-07 29.0 8.7 4.2e-05 23.3 3.0 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.4 001173445.1_22422001_1 - 0.033 13.8 9.3 0.4 10.3 1.6 2.5 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.4 001173445.1_22422001_1 - 0.048 13.4 5.9 1 9.1 0.3 2.5 2 0 0 2 2 2 0 Zinc knuckle S1 PF00575.21 001173445.1_22422001_1 - 0.15 12.3 0.0 0.24 11.7 0.0 1.3 1 0 0 1 1 1 0 S1 RNA binding domain CusF_Ec PF11604.6 001173445.1_22422001_1 - 0.17 11.7 0.0 0.28 11.0 0.0 1.3 1 0 0 1 1 1 0 Copper binding periplasmic protein CusF TAP42 PF04177.10 001195789.1_29623001_1 - 1.5e-87 293.6 13.3 1.6e-87 293.5 13.3 1.0 1 0 0 1 1 1 1 TAP42-like family MDM31_MDM32 PF08118.9 001195789.1_29623001_1 - 0.24 9.9 2.9 0.16 10.5 0.1 1.8 2 0 0 2 2 2 0 Yeast mitochondrial distribution and morphology (MDM) proteins Fer4_22 PF17179.2 001195789.1_29623001_1 - 0.27 12.0 3.0 0.82 10.4 0.6 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain Ribosomal_60s PF00428.17 001195789.1_29623001_1 - 1.3 9.4 7.6 0.12 12.9 2.0 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein FUSC PF04632.10 001195789.1_29623001_1 - 9.5 4.5 5.7 3.9 5.8 3.5 1.4 1 1 0 1 1 1 0 Fusaric acid resistance protein family CC2-LZ PF16516.3 001171494.1_37923001_1 - 6.3e-30 103.4 18.8 6.3e-30 103.4 18.8 3.9 1 1 2 3 3 3 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator NEMO PF11577.6 001171494.1_37923001_1 - 8.2e-26 89.7 12.3 8.2e-26 89.7 12.3 4.9 4 2 2 6 6 6 1 NF-kappa-B essential modulator NEMO Golgin_A5 PF09787.7 001171494.1_37923001_1 - 1.8 7.8 67.1 0.35 10.1 19.3 3.1 1 1 2 3 3 3 0 Golgin subfamily A member 5 LLC1 PF14945.4 001171494.1_37923001_1 - 1.9 9.0 9.8 0.11 13.0 0.7 3.0 1 1 3 4 4 4 0 Normal lung function maintenance, Low in Lung Cancer 1 protein 7tm_1 PF00001.19 001145084.1_32323001_1 - 5.6e-41 140.4 16.9 7.1e-41 140.1 16.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 001145084.1_32323001_1 - 1.5e-06 27.7 17.7 3.3e-06 26.5 17.6 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 001145084.1_32323001_1 - 4.1e-06 26.6 10.5 3e-05 23.8 2.7 2.1 2 0 0 2 2 2 2 Olfactory receptor WBP-1 PF11669.6 001145084.1_32323001_1 - 0.23 12.0 4.2 0.085 13.4 1.1 1.9 2 0 0 2 2 2 0 WW domain-binding protein 1 Peptidase_M56 PF05569.9 001145084.1_32323001_1 - 6.4 5.7 6.4 1.5 7.8 0.1 2.6 3 0 0 3 3 3 0 BlaR1 peptidase M56 DUF4407 PF14362.4 001145084.1_32323001_1 - 8.8 5.4 7.3 6.7 5.8 5.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) 7tm_1 PF00001.19 214090.1_49823001_1 - 1.7e-38 132.3 14.8 2.1e-38 132.0 14.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 214090.1_49823001_1 - 1.7e-07 30.7 15.7 4.4e-07 29.4 15.7 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 214090.1_49823001_1 - 5.2e-06 26.3 11.1 2e-05 24.4 3.9 2.1 2 0 0 2 2 2 2 Olfactory receptor HCV_core PF01542.16 214090.1_49823001_1 - 0.011 16.0 0.4 0.03 14.6 0.4 1.7 1 0 0 1 1 1 0 Hepatitis C virus core protein WBP-1 PF11669.6 214090.1_49823001_1 - 0.055 14.0 1.1 0.055 14.0 1.1 2.0 2 0 0 2 2 2 0 WW domain-binding protein 1 TctB PF07331.9 214090.1_49823001_1 - 6.4 6.9 16.9 0.79 9.9 3.4 3.0 1 1 2 3 3 3 0 Tripartite tricarboxylate transporter TctB family 7tm_1 PF00001.19 001009127.1_39723001_1 - 1.2e-43 149.2 13.1 1.5e-43 148.8 13.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 001009127.1_39723001_1 - 6.2e-07 28.9 13.4 1.2e-06 28.0 13.3 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 001009127.1_39723001_1 - 2.3e-05 24.1 9.2 0.00015 21.5 2.0 2.2 2 0 0 2 2 2 2 Olfactory receptor WBP-1 PF11669.6 001009127.1_39723001_1 - 0.49 10.9 5.4 0.11 13.0 0.8 2.1 2 0 0 2 2 2 0 WW domain-binding protein 1 Tim17 PF02466.17 001195660.1_29623001_1 - 5.4e-28 97.3 3.7 7.9e-28 96.7 3.7 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family 3Beta_HSD PF01073.17 001004049.2_49824001_2 - 1.2e-105 352.4 0.0 1.5e-105 352.1 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 001004049.2_49824001_2 - 2.6e-24 85.9 0.0 3.6e-24 85.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.10 001004049.2_49824001_2 - 2.3e-14 53.1 0.5 1.4e-13 50.5 0.5 1.9 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.3 001004049.2_49824001_2 - 1.9e-13 50.4 0.0 8.5e-13 48.2 0.0 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.13 001004049.2_49824001_2 - 1.1e-10 41.0 0.2 1.6e-10 40.5 0.2 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.4 001004049.2_49824001_2 - 2e-08 34.2 0.0 2.9e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.15 001004049.2_49824001_2 - 1.7e-05 23.9 0.0 2.5e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.8 001004049.2_49824001_2 - 3.3e-05 23.7 0.1 7.7e-05 22.5 0.1 1.5 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.16 001004049.2_49824001_2 - 0.0029 17.7 0.1 0.0055 16.8 0.1 1.5 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NmrA PF05368.11 001004049.2_49824001_2 - 0.0034 16.9 0.1 0.005 16.3 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family WD40 PF00400.30 001258128.1_29627001_3 - 8e-26 89.7 5.1 1.1e-05 26.0 0.0 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001258128.1_29627001_3 - 8.5e-14 51.5 5.3 1.6e-05 25.0 0.2 4.3 2 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 001258128.1_29627001_3 - 9.9e-05 22.2 0.1 0.53 10.0 0.0 3.0 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.3 001258128.1_29627001_3 - 0.067 12.0 0.0 0.28 10.0 0.0 1.9 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.6 001258128.1_29627001_3 - 0.067 11.7 0.2 0.14 10.6 0.2 1.4 1 0 0 1 1 1 0 Nucleoporin Nup120/160 RRM_1 PF00076.20 001168958.1_40423001_1 - 3.4e-54 180.4 0.0 5.5e-20 70.8 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001168958.1_40423001_1 - 2.6e-07 30.5 0.1 0.15 12.1 0.0 3.8 3 0 0 3 3 3 3 RNA recognition motif RNA_bind PF08675.9 001168958.1_40423001_1 - 2.3e-05 24.2 0.0 0.17 11.8 0.0 3.8 3 1 0 3 3 3 2 RNA binding domain TFIIA PF03153.11 001168958.1_40423001_1 - 0.0013 18.7 22.0 0.0018 18.2 22.0 1.4 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Nup35_RRM_2 PF14605.4 001168958.1_40423001_1 - 0.0021 17.9 0.0 3.2 7.6 0.0 3.8 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif DUF2722 PF10846.6 001168958.1_40423001_1 - 0.0089 14.9 7.5 0.016 14.0 7.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Spt20 PF12090.6 001168958.1_40423001_1 - 0.016 14.7 13.5 0.026 14.0 13.5 1.3 1 0 0 1 1 1 0 Spt20 family SARAF PF06682.10 001168958.1_40423001_1 - 1.7 8.1 7.8 2.9 7.3 7.8 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis IMUP PF15761.3 001168958.1_40423001_2 - 0.22 12.1 11.1 0.43 11.2 11.1 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein HEAT_2 PF13646.4 001194157.1_29624001_2 - 3.3e-31 107.4 16.8 1.7e-13 50.6 0.1 3.6 2 2 2 4 4 4 4 HEAT repeats HEAT_PBS PF03130.14 001194157.1_29624001_2 - 6.4e-22 75.8 19.2 0.00048 20.4 0.0 6.6 6 0 0 6 6 6 5 PBS lyase HEAT-like repeat HEAT PF02985.20 001194157.1_29624001_2 - 2.1e-06 27.3 7.1 0.13 12.4 0.3 5.3 5 0 0 5 5 5 2 HEAT repeat MGTL PF17059.3 001194157.1_29624001_2 - 0.00068 19.1 0.0 0.0022 17.5 0.0 2.0 1 0 0 1 1 1 1 MgtA leader peptide Arm PF00514.21 001194157.1_29624001_2 - 0.01 15.8 0.7 5 7.2 0.3 2.9 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.4 001194157.1_29624001_2 - 0.041 14.2 9.9 0.22 11.9 0.9 4.4 4 1 1 5 5 5 0 HEAT-like repeat TAF6_C PF07571.11 001194157.1_29624001_2 - 0.1 12.8 0.0 22 5.4 0.0 2.6 2 0 0 2 2 2 0 TAF6 C-terminal HEAT repeat domain zf-Tim10_DDP PF02953.13 001265859.1_29622001_2 - 2.4e-23 81.4 1.4 3.5e-23 80.9 1.4 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger dDENN PF03455.17 001265859.1_29622001_2 - 0.065 13.1 0.1 1.8 8.5 0.0 2.5 2 0 0 2 2 2 0 dDENN domain Alba PF01918.19 001265677.1_29622001_2 - 1.7e-16 59.7 0.0 2.3e-16 59.2 0.0 1.2 1 0 0 1 1 1 1 Alba RRM_1 PF00076.20 001280200.1_39724001_3 - 3.3e-52 174.1 0.0 3e-18 65.3 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.9 001280200.1_39724001_3 - 2.8e-09 36.7 0.0 0.056 13.3 0.0 3.8 3 1 0 3 3 3 3 RNA binding domain RRM_5 PF13893.4 001280200.1_39724001_3 - 6e-06 25.7 0.5 0.024 14.1 0.1 3.3 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001280200.1_39724001_3 - 6.3e-06 26.1 0.0 0.23 11.5 0.0 3.4 3 0 0 3 3 3 2 RNA recognition motif Nup35_RRM_2 PF14605.4 001280200.1_39724001_3 - 0.00038 20.2 0.0 0.3 10.9 0.0 3.4 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif BRAP2 PF07576.10 001280200.1_39724001_3 - 0.016 15.3 0.1 5.8 7.1 0.0 3.1 3 0 0 3 3 3 0 BRCA1-associated protein 2 PHM7_cyt PF14703.4 001280200.1_39724001_3 - 0.055 13.6 7.1 5.2 7.1 2.1 4.0 3 2 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter CD4-extracel PF09191.8 001001908.2_49826001_2 - 1e-45 154.4 0.3 2.4e-45 153.2 0.3 1.6 1 0 0 1 1 1 1 CD4, extracellular C2-set PF05790.13 001001908.2_49826001_2 - 8.8e-36 121.8 7.7 1.8e-18 66.4 0.1 3.6 4 0 0 4 4 3 2 Immunoglobulin C2-set domain ig PF00047.23 001001908.2_49826001_2 - 1.3e-22 79.7 3.0 2.5e-16 59.5 0.0 4.1 4 0 0 4 4 4 2 Immunoglobulin domain Tcell_CD4_C PF12104.6 001001908.2_49826001_2 - 2.8e-13 49.4 12.3 5.7e-13 48.4 12.3 1.5 1 0 0 1 1 1 1 T cell CD4 receptor C terminal region Ig_3 PF13927.4 001001908.2_49826001_2 - 1e-12 48.3 2.8 9.9e-05 22.8 0.0 4.8 5 0 0 5 5 5 2 Immunoglobulin domain Ig_2 PF13895.4 001001908.2_49826001_2 - 1.2e-10 41.4 1.9 0.00013 22.1 0.0 4.4 3 1 1 4 4 4 2 Immunoglobulin domain V-set PF07686.15 001001908.2_49826001_2 - 6.1e-10 39.1 0.1 2.6e-05 24.2 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin V-set domain I-set PF07679.14 001001908.2_49826001_2 - 1.7e-07 31.0 0.3 0.0045 16.9 0.0 4.1 3 1 1 4 4 4 2 Immunoglobulin I-set domain Receptor_2B4 PF11465.6 001001908.2_49826001_2 - 0.00051 20.1 0.0 0.0016 18.5 0.0 1.8 2 0 0 2 2 2 1 Natural killer cell receptor 2B4 Ig_5 PF16681.3 001001908.2_49826001_2 - 0.001 19.3 0.0 0.81 10.0 0.0 2.8 1 1 1 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Herpes_gE PF02480.14 001001908.2_49826001_2 - 0.0019 16.9 0.1 0.048 12.3 0.1 2.3 2 0 0 2 2 2 1 Alphaherpesvirus glycoprotein E DUF1191 PF06697.10 001001908.2_49826001_2 - 0.067 12.3 0.1 0.13 11.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) Myc_target_1 PF15179.4 001001908.2_49826001_2 - 0.095 12.5 1.0 0.52 10.1 0.1 2.2 2 0 0 2 2 2 0 Myc target protein 1 RRM_1 PF00076.20 001171308.1_37923001_1 - 3.2e-54 180.5 0.0 5.4e-20 70.9 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001171308.1_37923001_1 - 2.7e-07 30.5 0.1 0.15 12.1 0.0 3.8 3 0 0 3 3 3 3 RNA recognition motif RNA_bind PF08675.9 001171308.1_37923001_1 - 2.2e-05 24.3 0.0 0.17 11.8 0.0 3.8 3 1 0 3 3 3 2 RNA binding domain Nup35_RRM_2 PF14605.4 001171308.1_37923001_1 - 0.002 17.9 0.0 3.2 7.7 0.0 3.8 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif TFIIA PF03153.11 001171308.1_37923001_1 - 0.034 14.0 18.3 0.048 13.5 18.3 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Nup35_RRM PF05172.11 001171308.1_37923001_1 - 0.037 13.9 0.3 0.68 9.8 0.1 2.8 3 1 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Spt20 PF12090.6 001171308.1_37923001_1 - 0.048 13.1 6.4 0.076 12.5 6.4 1.3 1 0 0 1 1 1 0 Spt20 family PHM7_cyt PF14703.4 001171308.1_37923001_1 - 0.14 12.3 5.1 7.5 6.6 0.0 3.9 5 0 0 5 5 5 0 Cytosolic domain of 10TM putative phosphate transporter RRM_3 PF08777.9 001171308.1_37923001_1 - 0.7 9.8 6.9 5.8 6.9 0.0 3.3 4 0 0 4 4 4 0 RNA binding motif Peripla_BP_4 PF13407.4 001171308.1_37923001_1 - 4 6.8 11.0 0.99 8.8 5.1 2.6 2 1 0 2 2 2 0 Periplasmic binding protein domain SPX PF03105.17 001171308.1_37923001_2 - 3.9 7.2 8.9 5.3 6.7 8.9 1.2 1 0 0 1 1 1 0 SPX domain Arf PF00025.19 001048072.2_49824001_3 - 1.8e-75 252.1 0.2 2.3e-75 251.7 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 001048072.2_49824001_3 - 4.6e-13 49.3 0.0 6.6e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 001048072.2_49824001_3 - 1.4e-12 47.3 0.0 1.9e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.20 001048072.2_49824001_3 - 1.6e-12 47.2 0.0 2.3e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 Ras family G-alpha PF00503.18 001048072.2_49824001_3 - 2.7e-11 43.1 0.8 5.1e-08 32.3 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 001048072.2_49824001_3 - 2.6e-09 36.6 0.0 3.4e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001048072.2_49824001_3 - 0.00062 19.7 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.16 001048072.2_49824001_3 - 0.046 12.9 0.1 0.079 12.1 0.1 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase MRP-L28 PF09812.7 001243560.1_49822001_2 - 8.5e-57 191.7 10.0 1e-56 191.4 10.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 SR-25 PF10500.7 033706.1_49823120_1 - 2.2e-75 253.1 17.5 3.2e-75 252.5 17.5 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein CCDC106 PF15794.3 033706.1_49823120_1 - 0.13 11.8 16.1 0.22 11.1 16.1 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Med19 PF10278.7 033706.1_49823120_1 - 0.2 11.4 15.4 0.36 10.6 15.4 1.3 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 IMUP PF15761.3 033706.1_49823120_1 - 0.21 12.2 24.0 0.45 11.1 24.0 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein DUF4614 PF15391.4 033706.1_49823120_1 - 0.53 10.1 6.5 0.84 9.5 6.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Dehydrin PF00257.17 033706.1_49823120_1 - 0.58 10.5 13.2 1 9.7 13.2 1.4 1 0 0 1 1 1 0 Dehydrin FAM199X PF15814.3 033706.1_49823120_1 - 0.68 8.8 6.5 0.98 8.3 6.5 1.1 1 0 0 1 1 1 0 Protein family FAM199X AP3D1 PF06375.9 033706.1_49823120_1 - 2 8.5 14.9 3.2 7.9 14.9 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF3827 PF12877.5 033706.1_49823120_1 - 3.3 5.8 8.3 4.5 5.4 8.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) SR-25 PF10500.7 033706.1_49823120_2 - 4.1e-08 33.0 13.4 4.1e-08 33.0 13.4 1.6 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein SR-25 PF10500.7 033706.1_49823120_3 - 0.0031 17.0 0.2 0.0031 17.0 0.2 1.5 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein NHL PF01436.19 001258302.1_49823001_3 - 1.3e-14 53.3 4.7 0.6 10.1 0.0 6.5 6 0 0 6 6 6 5 NHL repeat zf-RING_5 PF14634.4 001258302.1_49823001_3 - 4.6e-08 32.8 7.4 8.8e-08 31.9 7.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.4 001258302.1_49823001_3 - 3.5e-07 30.3 8.1 9.7e-07 28.8 8.1 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.4 001258302.1_49823001_3 - 5.9e-06 26.1 1.4 5.9e-06 26.1 1.4 2.0 1 1 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.4 001258302.1_49823001_3 - 6.6e-06 25.8 7.0 1.6e-05 24.5 7.0 1.7 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.4 001258302.1_49823001_3 - 7.1e-05 22.5 12.7 0.00014 21.5 12.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001258302.1_49823001_3 - 0.00038 20.4 3.9 0.00038 20.4 3.9 2.1 2 1 0 2 2 1 1 zinc finger of C3HC4-type, RING Baculo_IE-1 PF05290.9 001258302.1_49823001_3 - 0.00069 19.4 1.3 0.0012 18.6 1.3 1.3 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-C3HC4 PF00097.23 001258302.1_49823001_3 - 0.00077 19.1 6.0 0.0021 17.8 6.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 001258302.1_49823001_3 - 0.022 14.4 2.6 0.061 12.9 2.6 1.9 1 0 0 1 1 1 0 RING-like zinc finger zf-C3HC4_2 PF13923.4 001258302.1_49823001_3 - 0.87 9.3 11.8 0.15 11.8 7.6 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.19 001258302.1_49823001_3 - 7.8 6.6 13.0 19 5.4 13.0 1.6 1 0 0 1 1 1 0 FYVE zinc finger PINIT PF14324.4 001280525.1_39724001_1 - 2.2e-32 112.3 0.5 3.2e-32 111.7 0.5 1.3 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.18 001280525.1_39724001_1 - 1e-21 76.3 5.7 2.1e-21 75.2 5.7 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.6 001280525.1_39724001_1 - 2.5e-05 23.9 1.7 5.8e-05 22.7 1.7 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SAP PF02037.25 001280525.1_39724001_1 - 8.3e-05 22.1 0.3 0.00024 20.6 0.0 1.9 2 0 0 2 2 2 1 SAP domain DARPP-32 PF05395.10 001280525.1_39724001_1 - 0.045 13.8 2.4 6.9 6.7 0.9 2.3 2 0 0 2 2 2 0 Protein phosphatase inhibitor 1/DARPP-32 CENP-B_dimeris PF09026.8 001280525.1_39724001_1 - 0.42 10.9 5.9 0.77 10.1 5.9 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Sporozoite_P67 PF05642.9 001280525.1_39724001_1 - 0.52 8.2 3.4 0.75 7.7 3.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PINIT PF14324.4 001284657.1_29525001_3 - 5.8e-39 133.7 0.4 1.3e-38 132.5 0.4 1.7 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.18 001284657.1_29525001_3 - 8.3e-21 73.4 5.0 1.9e-20 72.2 5.0 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.6 001284657.1_29525001_3 - 0.00026 20.6 1.5 0.00065 19.3 1.5 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4 PF00097.23 001284657.1_29525001_3 - 1.1 9.1 4.9 3.5 7.5 4.9 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) UPF0544 PF15749.3 001284657.1_29525001_3 - 3.5 8.3 7.0 32 5.1 7.0 2.4 1 1 0 1 1 1 0 Uncharacterised protein family UPF0544 Herpes_capsid PF06112.9 001284657.1_29525001_3 - 8.2 6.3 8.9 16 5.4 7.9 1.9 2 0 0 2 2 2 0 Gammaherpesvirus capsid protein zinc_ribbon_6 PF14599.4 001261545.1_29625001_3 - 1.6e-27 95.1 1.4 1.6e-27 95.1 1.4 3.0 3 1 0 3 3 3 1 Zinc-ribbon zf-CHY PF05495.10 001261545.1_29625001_3 - 2.1e-20 72.9 23.0 2.1e-20 72.9 23.0 3.9 3 1 0 3 3 3 1 CHY zinc finger zf-RING_2 PF13639.4 001261545.1_29625001_3 - 4.1e-10 39.6 6.3 4.1e-10 39.6 6.3 5.7 5 1 1 6 6 6 1 Ring finger domain zf-C3HC4_2 PF13923.4 001261545.1_29625001_3 - 1.7e-06 27.6 6.4 1.7e-06 27.6 6.4 4.4 4 2 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001261545.1_29625001_3 - 9.6e-06 25.3 4.9 9.6e-06 25.3 4.9 5.7 3 1 3 6 6 6 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 001261545.1_29625001_3 - 0.00022 21.1 7.2 0.00022 21.1 7.2 3.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_11 PF17123.3 001261545.1_29625001_3 - 0.00028 20.4 4.0 0.00028 20.4 4.0 3.1 2 0 0 2 2 2 1 RING-like zinc finger Ribosomal_L19e PF01280.18 001304909.1_01322001_1 - 3.1e-67 225.0 12.5 3.1e-67 225.0 12.5 1.9 1 1 1 2 2 2 1 Ribosomal protein L19e DUF1682 PF07946.12 001304909.1_01322001_1 - 6.8 5.7 15.8 9 5.3 15.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) PINIT PF14324.4 001266301.2_29625001_2 - 5.8e-39 133.6 0.4 1.3e-38 132.5 0.4 1.7 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.18 001266301.2_29625001_2 - 9.6e-21 73.2 5.0 1.9e-20 72.2 5.0 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.6 001266301.2_29625001_2 - 0.00027 20.6 1.5 0.00065 19.3 1.5 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4 PF00097.23 001266301.2_29625001_2 - 1.1 9.1 4.9 3.5 7.5 4.9 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) UPF0544 PF15749.3 001266301.2_29625001_2 - 4.1 8.0 7.0 32 5.1 7.0 2.3 1 1 0 1 1 1 0 Uncharacterised protein family UPF0544 Herpes_capsid PF06112.9 001266301.2_29625001_2 - 8.5 6.3 8.9 16 5.4 7.9 1.9 2 0 0 2 2 2 0 Gammaherpesvirus capsid protein SAP PF02037.25 001132147.1_43529001_1 - 1.1e-11 44.1 0.4 2.3e-11 43.0 0.4 1.6 1 0 0 1 1 1 1 SAP domain zf-C3HC4_2 PF13923.4 001132147.1_43529001_1 - 1.5e-07 31.0 8.9 1.5e-07 31.0 8.9 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001132147.1_43529001_1 - 5.5e-06 26.0 11.0 5.5e-06 26.0 11.0 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001132147.1_43529001_1 - 6e-06 25.9 19.0 6.6e-06 25.7 6.9 3.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001132147.1_43529001_1 - 8e-06 25.9 9.1 8e-06 25.9 9.1 3.1 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.4 001132147.1_43529001_1 - 9.5e-05 22.2 9.8 9.5e-05 22.2 9.8 2.9 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_6 PF14835.4 001132147.1_43529001_1 - 0.00014 21.6 3.2 0.00014 21.6 3.2 2.5 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.4 001132147.1_43529001_1 - 0.0013 18.6 10.2 0.0064 16.4 10.2 2.3 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.5 001132147.1_43529001_1 - 0.0063 16.6 5.9 0.0063 16.6 5.9 2.1 2 0 0 2 2 2 1 RING-H2 zinc finger domain LEM PF03020.13 001132147.1_43529001_1 - 0.16 11.4 0.2 0.33 10.4 0.2 1.5 1 0 0 1 1 1 0 LEM domain zinc_ribbon_6 PF14599.4 001163595.1_39522001_1 - 7.7e-28 96.2 1.8 7.7e-28 96.2 1.8 3.9 2 1 2 4 4 2 1 Zinc-ribbon zf-CHY PF05495.10 001163595.1_39522001_1 - 4.7e-21 75.0 22.3 4.7e-21 75.0 22.3 3.9 3 1 0 3 3 2 2 CHY zinc finger zf-RING_2 PF13639.4 001163595.1_39522001_1 - 4.5e-11 42.7 5.2 4.5e-11 42.7 5.2 5.7 4 2 2 6 6 4 1 Ring finger domain zf-C3HC4 PF00097.23 001163595.1_39522001_1 - 2.3e-07 30.4 4.9 2.3e-07 30.4 4.9 6.1 4 1 1 5 5 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001163595.1_39522001_1 - 4.4e-07 29.5 5.5 4.4e-07 29.5 5.5 5.6 5 2 1 6 6 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001163595.1_39522001_1 - 2e-06 27.6 2.3 2e-06 27.6 2.3 4.4 5 2 1 6 6 5 1 RING-type zinc-finger zf-RING_5 PF14634.4 001163595.1_39522001_1 - 4.7e-06 26.3 4.8 4.7e-06 26.3 4.8 6.3 3 2 1 4 4 3 1 zinc-RING finger domain zf-RING_11 PF17123.3 001163595.1_39522001_1 - 6.8e-06 25.6 2.5 6.8e-06 25.6 2.5 5.2 7 1 0 7 7 6 1 RING-like zinc finger Prok-RING_4 PF14447.4 001163595.1_39522001_1 - 8e-06 25.5 0.5 8e-06 25.5 0.5 6.0 4 2 3 7 7 4 2 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.4 001163595.1_39522001_1 - 1.1e-05 25.0 5.9 1.1e-05 25.0 5.9 6.4 2 1 3 5 5 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 001163595.1_39522001_1 - 0.028 14.6 7.4 0.028 14.6 7.4 5.2 3 2 1 4 4 3 0 RING-H2 zinc finger domain zf-RING_4 PF14570.4 001131625.1_43528001_2 - 6.7e-20 70.4 12.2 1.4e-19 69.4 12.2 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.20 001131625.1_43528001_2 - 2.2e-05 24.1 0.0 3.6e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-UDP PF14569.4 001131625.1_43528001_2 - 0.067 13.2 3.5 0.15 12.0 3.5 1.6 1 0 0 1 1 1 0 Zinc-binding RING-finger Btz PF09405.8 001260566.1_29628001_3 - 1.3e-23 83.5 6.3 1.3e-23 83.5 6.3 2.2 1 1 1 2 2 2 1 CASC3/Barentsz eIF4AIII binding zinc_ribbon_6 PF14599.4 001097490.1_49822001_1 - 5.2e-28 96.7 1.6 5.2e-28 96.7 1.6 3.9 2 1 2 4 4 4 1 Zinc-ribbon zf-CHY PF05495.10 001097490.1_49822001_1 - 2.9e-21 75.7 22.6 2.9e-21 75.7 22.6 4.0 2 1 1 3 3 3 2 CHY zinc finger zf-RING_2 PF13639.4 001097490.1_49822001_1 - 2.2e-10 40.5 7.6 2.2e-10 40.5 7.6 5.9 4 2 1 5 5 5 1 Ring finger domain zf-C3HC4 PF00097.23 001097490.1_49822001_1 - 4.6e-07 29.5 7.3 4.6e-07 29.5 7.3 5.7 4 1 2 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001097490.1_49822001_1 - 1.4e-06 27.9 7.7 1.4e-06 27.9 7.7 5.7 5 2 1 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001097490.1_49822001_1 - 1.8e-06 27.7 2.7 1.8e-06 27.7 2.7 4.8 5 3 1 6 6 6 1 RING-type zinc-finger zf-RING_5 PF14634.4 001097490.1_49822001_1 - 1.6e-05 24.6 6.9 1.6e-05 24.6 6.9 6.3 4 2 1 5 5 5 1 zinc-RING finger domain Prok-RING_4 PF14447.4 001097490.1_49822001_1 - 2.5e-05 23.9 1.1 2.5e-05 23.9 1.1 6.2 4 2 1 5 5 5 2 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.4 001097490.1_49822001_1 - 5.1e-05 22.9 7.7 5.1e-05 22.9 7.7 6.4 2 1 3 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 001097490.1_49822001_1 - 0.0014 18.2 6.8 0.0014 18.2 6.8 5.2 6 1 0 6 6 6 1 RING-like zinc finger zf-UBR PF02207.18 001284741.1_29526001_1 - 5.7e-12 45.5 11.4 5.7e-12 45.5 11.4 3.2 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) PHD PF00628.27 001284741.1_29526001_1 - 0.00047 19.9 3.0 0.00047 19.9 3.0 3.2 3 0 0 3 3 3 1 PHD-finger Ufd2P_core PF10408.7 001244872.1_49827001_2 - 1.1e-153 513.1 9.0 1.4e-153 512.7 9.0 1.2 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.13 001244872.1_49827001_2 - 2.6e-32 110.7 0.5 9.2e-32 108.9 0.5 2.0 1 0 0 1 1 1 1 U-box domain RINGv PF12906.5 001266961.2_29627001_2 - 1.4e-09 37.7 15.0 4.3e-09 36.2 15.0 1.9 1 0 0 1 1 1 1 RING-variant domain MSA-2c PF12238.6 001266961.2_29627001_2 - 0.047 13.6 0.0 0.047 13.6 0.0 1.8 2 0 0 2 2 2 0 Merozoite surface antigen 2c RINGv PF12906.5 001246272.1_29623001_1 - 2.9e-11 43.2 10.9 5.1e-11 42.4 10.9 1.4 1 0 0 1 1 1 1 RING-variant domain zf-C3HC4 PF00097.23 001246272.1_29623001_1 - 0.12 12.1 3.5 0.45 10.3 3.5 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001246272.1_29623001_1 - 0.13 12.5 9.6 0.27 11.4 9.6 1.6 1 0 0 1 1 1 0 Ring finger domain UPAR_LY6 PF00021.19 001285284.1_29522001_2 - 2.1e-17 63.4 11.3 2.8e-17 63.1 11.3 1.2 1 0 0 1 1 1 1 u-PAR/Ly-6 domain KRTAP PF11759.6 001270487.1_32922001_2 - 0.0031 17.9 94.1 18 5.8 94.1 2.5 1 1 0 1 1 1 1 Keratin-associated matrix p450 PF00067.20 001100181.1_32924001_2 - 2.3e-131 438.6 0.0 2.8e-131 438.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 RhoGEF PF00621.18 001195036.1_32926001_3 - 1.3e-36 126.5 0.2 2.9e-36 125.3 0.2 1.7 1 0 0 1 1 1 1 RhoGEF domain DUF4347 PF14252.4 001195036.1_32926001_3 - 1.7e-12 47.3 0.0 1.6e-11 44.2 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4347) F-box-like PF12937.5 001195036.1_32926001_3 - 1.4e-06 28.0 0.8 5.2e-06 26.1 0.8 2.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001195036.1_32926001_3 - 6.5e-06 25.8 0.2 2.2e-05 24.1 0.2 1.9 1 0 0 1 1 1 1 F-box domain DUF4508 PF14969.4 001195036.1_32926001_3 - 0.011 15.8 8.5 0.054 13.6 1.3 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4508) Sec8_exocyst PF04048.12 001195036.1_32926001_3 - 0.027 14.2 0.3 0.74 9.6 0.0 2.7 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain NIR_SIR_ferr PF03460.15 001195036.1_32926001_3 - 0.07 12.9 0.0 0.2 11.4 0.0 1.8 1 0 0 1 1 1 0 Nitrite/Sulfite reductase ferredoxin-like half domain DUF4148 PF13663.4 001195036.1_32926001_3 - 0.15 12.1 0.5 0.31 11.1 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4148) PID_2 PF14719.4 001081672.2_32925001_2 - 4e-71 238.5 0.1 7.6e-71 237.6 0.1 1.5 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) DUF4732 PF15876.3 001106255.1_45723001_1 - 7.4e-79 263.4 0.3 1.1e-78 262.8 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4732) 2OG-FeII_Oxy_3 PF13640.4 001246513.1_39725001_1 - 1.3e-18 67.5 0.0 3e-18 66.4 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.4 001246513.1_39725001_1 - 2.1e-09 37.8 0.0 3.9e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily K_channel_TID PF07941.9 001246513.1_39725001_1 - 1.5 9.2 10.0 1.9 8.9 1.4 2.7 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain Abhydrolase_3 PF07859.11 001085542.1_32923001_1 - 3.1e-43 147.9 0.1 2.6e-31 109.0 0.2 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.26 001085542.1_32923001_1 - 0.0009 18.1 0.3 0.0047 15.8 0.3 1.9 1 1 0 1 1 1 1 Carboxylesterase family Lipase_3 PF01764.23 001085542.1_32923001_1 - 0.034 13.9 0.0 0.055 13.2 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Esterase_phd PF10503.7 001085542.1_32923001_1 - 0.11 11.8 0.1 0.19 11.1 0.1 1.2 1 0 0 1 1 1 0 Esterase PHB depolymerase COX6B PF02297.15 001348392.1_39724001_3 - 3.3e-16 59.1 2.4 5.5e-16 58.4 2.4 1.3 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CX9C PF16860.3 001348392.1_39724001_3 - 0.045 13.6 0.7 0.12 12.3 0.7 1.7 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, NUT PF12881.5 001348392.1_39724001_3 - 0.056 11.7 0.9 0.079 11.2 0.9 1.1 1 0 0 1 1 1 0 NUT protein ICMT PF04140.12 037908.1_32929120_3 - 6.4e-33 112.9 0.1 1.1e-32 112.1 0.1 1.4 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.11 037908.1_32929120_3 - 7.5e-07 29.4 0.4 1.3e-06 28.6 0.4 1.4 1 0 0 1 1 1 1 Phospholipid methyltransferase zf-H2C2_2 PF13465.4 027964.1_32922120_1 - 6.9e-07 29.3 5.1 0.018 15.4 1.8 2.6 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.24 027964.1_32922120_1 - 2.1e-05 24.6 2.0 4.4e-05 23.6 2.0 1.6 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 027964.1_32922120_1 - 0.00083 19.8 2.0 0.002 18.6 2.0 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_6 PF13912.4 027964.1_32922120_1 - 0.0029 17.4 0.9 0.0046 16.7 0.9 1.4 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 027964.1_32922120_1 - 0.0098 16.0 0.3 0.018 15.2 0.3 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 027964.1_32922120_1 - 0.045 13.4 1.0 0.11 12.2 1.0 1.7 1 0 0 1 1 1 0 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 027964.1_32922120_3 - 0.028 14.7 3.8 0.068 13.5 3.8 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 027964.1_32922120_3 - 5.1 8.1 9.6 0.19 12.5 3.3 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger CagY_M PF07337.9 126577.1_45722120_1 - 0.1 12.1 0.2 0.18 11.3 0.2 1.4 1 0 0 1 1 1 0 DC-EC Repeat CagY_M PF07337.9 126578.1_45722120_1 - 0.09 12.3 0.2 0.14 11.7 0.2 1.3 1 0 0 1 1 1 0 DC-EC Repeat KRAB PF01352.25 036450.1_32928120_1 - 3.6e-19 68.0 0.0 7.9e-19 66.9 0.0 1.6 1 0 0 1 1 1 1 KRAB box DUF3505 PF12013.6 036450.1_32928120_1 - 0.064 13.6 10.5 3 8.2 0.4 3.9 1 1 4 5 5 5 0 Protein of unknown function (DUF3505) DUF5132 PF17195.2 036450.1_32928120_1 - 0.28 11.2 4.5 87 3.2 0.0 4.9 6 0 0 6 6 6 0 Protein of unknown function (DUF5132) zf-Di19 PF05605.10 036450.1_32928120_1 - 3.8 7.7 6.1 57 4.0 0.0 3.6 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.4 036450.1_32928120_2 - 4.3e-05 23.6 14.4 0.017 15.4 0.4 5.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.24 036450.1_32928120_2 - 1.9 9.0 5.0 4.8 7.7 0.1 3.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 036450.1_32928120_3 - 2.3e-54 179.4 77.3 5.3e-09 36.0 0.7 13.2 13 0 0 13 13 13 10 Zinc-finger double domain zf-C2H2 PF00096.24 036450.1_32928120_3 - 1.2e-27 94.7 62.7 5.2e-06 26.5 0.5 11.6 12 0 0 12 12 12 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 036450.1_32928120_3 - 1.1e-14 53.7 60.0 0.00095 19.7 0.5 10.9 12 0 0 12 12 11 5 C2H2-type zinc finger zf-C2H2_6 PF13912.4 036450.1_32928120_3 - 2.7e-11 43.0 52.9 2.8e-05 23.8 0.5 8.2 10 0 0 10 10 10 5 C2H2-type zinc finger DUF3268 PF11672.6 036450.1_32928120_3 - 0.00013 22.2 12.5 0.18 12.0 0.4 3.4 3 0 0 3 3 3 3 zinc-finger-containing domain zf-C2H2_jaz PF12171.6 036450.1_32928120_3 - 0.0005 20.2 33.3 0.12 12.5 0.4 7.3 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding GATA PF00320.25 036450.1_32928120_3 - 0.0039 16.6 13.9 13 5.3 0.0 5.6 4 1 1 5 5 5 1 GATA zinc finger zf-ribbon_3 PF13248.4 036450.1_32928120_3 - 0.025 13.8 13.5 7.5 6.0 0.1 5.7 5 0 0 5 5 5 0 zinc-ribbon domain C1_4 PF07975.10 036450.1_32928120_3 - 0.051 13.7 24.5 0.26 11.5 3.8 4.9 1 1 2 4 4 4 0 TFIIH C1-like domain zf-C2H2_11 PF16622.3 036450.1_32928120_3 - 0.13 11.9 26.5 0.43 10.2 0.0 6.9 7 0 0 7 7 7 0 zinc-finger C2H2-type XPA_N PF01286.16 036450.1_32928120_3 - 0.34 10.9 22.8 11 6.0 0.1 7.1 7 0 0 7 7 7 0 XPA protein N-terminal Glutaredoxin PF00462.22 033611.1_32923120_2 - 8.8e-37 125.0 0.0 4.3e-17 62.0 0.0 2.4 2 0 0 2 2 2 2 Glutaredoxin SH3BGR PF04908.13 033611.1_32923120_2 - 2.4e-06 27.5 0.0 0.064 13.3 0.0 2.4 2 0 0 2 2 2 2 SH3-binding, glutamic acid-rich protein CNOT1_HEAT_N PF16419.3 033611.1_32923120_2 - 0.083 12.4 0.1 8 5.9 0.0 2.1 1 1 0 2 2 2 0 CCR4-NOT transcription complex subunit 1 HEAT repeat RdRP PF05183.10 033611.1_32923120_2 - 0.17 10.4 0.0 5.7 5.3 0.0 2.0 1 1 1 2 2 2 0 RNA dependent RNA polymerase Thioredoxin PF00085.18 033611.1_32923120_3 - 7.2e-19 67.5 0.1 1e-18 67.1 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.14 033611.1_32923120_3 - 2.9e-06 26.3 0.0 4e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Phosducin Thioredoxin_2 PF13098.4 033611.1_32923120_3 - 7.8e-06 26.2 0.0 1.7e-05 25.1 0.0 1.6 1 1 0 1 1 1 1 Thioredoxin-like domain DIM1 PF02966.14 033611.1_32923120_3 - 9.6e-06 25.3 0.0 1.5e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Mitosis protein DIM1 HyaE PF07449.9 033611.1_32923120_3 - 0.00075 19.3 0.1 0.0012 18.6 0.1 1.3 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE OST3_OST6 PF04756.11 033611.1_32923120_3 - 0.023 13.9 0.1 0.032 13.4 0.1 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Thioredoxin_3 PF13192.4 033611.1_32923120_3 - 0.032 14.1 0.0 0.058 13.3 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin domain Thioredoxin_9 PF14595.4 033611.1_32923120_3 - 0.069 12.8 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_8 PF13905.4 033611.1_32923120_3 - 0.11 12.7 0.0 1.2 9.3 0.0 2.2 1 1 1 2 2 2 0 Thioredoxin-like DUF2464 PF10240.7 001348403.1_39722001_3 - 0.0034 16.8 0.1 0.0036 16.7 0.1 1.1 1 0 0 1 1 1 1 Multivesicular body subunit 12 Ig_3 PF13927.4 001202444.1_29624001_2 - 2.3e-10 40.8 0.5 0.0001 22.7 0.0 3.5 2 1 1 3 3 3 2 Immunoglobulin domain V-set PF07686.15 001202444.1_29624001_2 - 6.6e-10 39.0 0.1 6.9e-08 32.5 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin V-set domain Gag_MA PF01140.17 001202444.1_29624001_2 - 8.5e-10 38.3 0.2 4e-09 36.1 0.1 2.2 3 0 0 3 3 3 1 Matrix protein (MA), p15 C1-set PF07654.13 001202444.1_29624001_2 - 1.1e-09 38.5 0.5 1.1e-08 35.2 0.2 2.7 3 0 0 3 3 3 1 Immunoglobulin C1-set domain ig PF00047.23 001202444.1_29624001_2 - 2.5e-07 30.7 1.3 0.011 15.7 0.0 3.5 2 2 1 3 3 3 2 Immunoglobulin domain V-set_CD47 PF08204.9 001202444.1_29624001_2 - 2e-06 27.7 0.0 6.5e-06 26.0 0.0 1.8 2 0 0 2 2 2 1 CD47 immunoglobulin-like domain Izumo-Ig PF16706.3 001202444.1_29624001_2 - 3.6e-05 23.6 0.1 0.011 15.6 0.0 3.3 2 1 1 3 3 3 1 Izumo-like Immunoglobulin domain I-set PF07679.14 001202444.1_29624001_2 - 0.00094 19.1 0.0 0.014 15.3 0.0 2.7 3 1 0 3 3 3 1 Immunoglobulin I-set domain C2-set_2 PF08205.10 001202444.1_29624001_2 - 0.0025 17.7 0.1 0.0063 16.4 0.1 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Synaphin PF05835.10 001348410.1_29623001_3 - 1.6e-41 141.8 17.7 2.3e-41 141.3 17.7 1.2 1 0 0 1 1 1 1 Synaphin protein DUF2570 PF10828.6 001348410.1_29623001_3 - 1.3 8.8 7.8 2 8.2 7.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) RR_TM4-6 PF06459.10 001348410.1_29623001_3 - 3 7.5 10.5 4.2 7.0 10.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Spt5_N PF11942.6 001348410.1_29623001_3 - 5.3 8.0 19.4 0.66 10.9 12.2 2.1 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal KRAB PF01352.25 001199670.1_39523001_1 - 8.2e-26 89.3 0.4 1.9e-25 88.1 0.4 1.7 1 0 0 1 1 1 1 KRAB box RVT_1 PF00078.25 001199670.1_39523001_1 - 1.4e-08 34.4 0.0 2.3e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TLV_coat PF00429.17 001305591.1_22423001_1 - 3.2e-10 39.2 6.7 4.9e-10 38.6 1.4 2.7 2 1 0 2 2 2 2 ENV polyprotein (coat polyprotein) Corona_S2 PF01601.14 001305591.1_22423001_1 - 0.82 8.0 6.4 1.2 7.4 6.4 1.3 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein KRAB PF01352.25 001348418.1_39522001_2 - 1.8e-25 88.2 0.4 1.8e-25 88.2 0.4 1.8 2 0 0 2 2 2 1 KRAB box TLV_coat PF00429.17 001306194.1_29624001_1 - 2.1e-29 102.5 0.0 2.1e-29 102.5 0.0 2.3 2 2 1 3 3 3 1 ENV polyprotein (coat polyprotein) RAWUL PF16207.3 001081482.1_39723001_1 - 4.3e-29 100.8 0.0 8.2e-29 99.9 0.0 1.5 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_2 PF13923.4 001081482.1_39723001_1 - 7.7e-16 57.5 10.4 1.2e-15 56.9 10.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001081482.1_39723001_1 - 1.2e-10 40.9 10.3 2.1e-10 40.2 10.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001081482.1_39723001_1 - 6.4e-09 35.8 8.7 1e-08 35.1 8.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.4 001081482.1_39723001_1 - 6.7e-08 32.1 7.8 1e-07 31.6 7.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001081482.1_39723001_1 - 1.4e-05 24.8 7.4 2.7e-05 23.9 7.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.4 001081482.1_39723001_1 - 4.6e-05 23.2 8.6 7.4e-05 22.5 8.6 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.4 001081482.1_39723001_1 - 8.1e-05 22.6 7.9 0.00013 21.9 7.9 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.6 001081482.1_39723001_1 - 8.8e-05 22.1 5.3 0.00014 21.4 5.3 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.4 001081482.1_39723001_1 - 0.00022 20.9 3.9 0.00041 20.0 3.9 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_4 PF14570.4 001081482.1_39723001_1 - 0.00028 20.4 6.3 0.00058 19.4 6.3 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.5 001081482.1_39723001_1 - 0.0012 18.9 6.9 0.0029 17.7 6.9 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.4 001081482.1_39723001_1 - 0.045 13.5 8.9 0.46 10.2 9.2 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_5 PF17121.3 001081482.1_39723001_1 - 0.072 12.9 7.7 0.21 11.4 7.6 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-UDP PF14569.4 001081482.1_39723001_1 - 0.077 13.0 5.1 0.12 12.3 2.1 2.2 2 0 0 2 2 2 0 Zinc-binding RING-finger zf-RING_11 PF17123.3 001081482.1_39723001_1 - 0.27 10.9 4.7 0.64 9.7 4.7 1.6 1 0 0 1 1 1 0 RING-like zinc finger zf-MIZ PF02891.18 001081482.1_39723001_1 - 1 9.0 6.9 1.8 8.2 6.9 1.4 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger DZR PF12773.5 001081482.1_39723001_1 - 4 7.4 6.6 36 4.3 6.6 2.3 1 1 0 1 1 1 0 Double zinc ribbon Hydrolase_6 PF13344.4 001284981.1_29524001_1 - 6.5e-19 67.8 0.0 1.2e-18 67.0 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.4 001284981.1_29524001_1 - 1.4e-06 28.2 0.0 0.00012 21.9 0.0 3.1 3 0 0 3 3 3 1 HAD-hyrolase-like DUF4205 PF13898.4 001279924.1_39725001_1 - 1.9e-54 184.8 0.0 1.1e-51 175.6 0.0 2.4 2 1 0 2 2 2 2 Domain of unknown function (DUF4205) Hydrolase_6 PF13344.4 001194230.1_29624001_2 - 6.8e-19 67.7 0.0 1.2e-18 66.9 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.4 001194230.1_29624001_2 - 1.5e-06 28.0 0.0 0.00012 21.9 0.0 3.0 3 0 0 3 3 3 1 HAD-hyrolase-like MHC_I PF00129.16 001301848.2_08024001_1 - 7.7e-94 312.1 1.4 1.1e-93 311.6 1.4 1.3 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001301848.2_08024001_1 - 1.3e-16 60.7 0.1 2.7e-16 59.7 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001301848.2_08024001_1 - 5.6e-16 58.0 4.2 1.1e-15 57.1 4.2 1.5 1 0 0 1 1 1 1 MHC_I C-terminus MHC_I_3 PF16497.3 001301848.2_08024001_1 - 3.4e-06 26.5 0.0 4.9e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain C2-set_2 PF08205.10 001301848.2_08024001_1 - 0.0005 20.0 0.2 0.0012 18.8 0.2 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ank_2 PF12796.5 001201383.2_49829001_1 - 6e-151 491.3 38.1 1.3e-19 70.4 0.9 12.3 3 3 9 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001201383.2_49829001_1 - 3.2e-126 410.1 14.6 4.7e-12 46.0 0.0 16.7 7 4 9 17 17 17 17 Ankyrin repeats (many copies) Ank PF00023.28 001201383.2_49829001_1 - 4.8e-113 365.0 56.5 5.2e-08 32.9 0.0 25.1 25 0 0 25 25 25 21 Ankyrin repeat Ank_3 PF13606.4 001201383.2_49829001_1 - 2.5e-103 325.3 32.6 6.7e-05 22.9 0.0 25.3 25 0 0 25 25 25 22 Ankyrin repeat Ank_5 PF13857.4 001201383.2_49829001_1 - 4.8e-100 325.7 50.1 2.9e-10 40.1 0.0 21.3 7 4 14 21 21 21 21 Ankyrin repeats (many copies) KH_1 PF00013.27 001201383.2_49829001_1 - 2.5e-15 55.9 3.9 3.4e-15 55.5 2.4 2.2 2 0 0 2 2 2 1 KH domain KH_4 PF13083.4 001201383.2_49829001_1 - 0.041 13.6 0.0 0.15 11.8 0.0 2.0 1 0 0 1 1 1 0 KH domain Herpes_PAP PF03325.11 001201383.2_49829001_1 - 1.2 8.0 9.9 2.6 7.0 9.9 1.5 1 0 0 1 1 1 0 Herpesvirus polymerase accessory protein TPP1 PF10341.7 145824.1_32924120_1 - 5.4e-20 71.3 0.0 7.6e-20 70.8 0.0 1.2 1 0 0 1 1 1 1 Shelterin complex subunit, TPP1/ACD OGFr_III PF04680.11 145824.1_32924120_1 - 0.062 13.8 0.6 0.35 11.4 0.6 2.4 1 0 0 1 1 1 0 Opioid growth factor receptor repeat Peptidase_M2 PF01401.16 001083941.2_49829001_1 - 0 1715.3 5.7 8e-260 863.2 1.1 2.0 2 0 0 2 2 2 2 Angiotensin-converting enzyme DHHA2 PF02833.12 001280211.1_39725001_2 - 2.1e-29 102.3 0.0 3.6e-29 101.6 0.0 1.4 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.18 001280211.1_39725001_2 - 2.5e-09 37.2 0.1 4.9e-09 36.2 0.1 1.4 1 0 0 1 1 1 1 DHH family Pkinase PF00069.23 001113437.2_49829001_1 - 9.7e-41 139.7 0.0 2.2e-40 138.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001113437.2_49829001_1 - 2.2e-39 135.2 0.0 4.3e-39 134.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Roc PF08477.11 001113437.2_49829001_1 - 3.6e-30 104.5 0.1 1.3e-29 102.7 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase LRR_4 PF12799.5 001113437.2_49829001_1 - 1.5e-27 94.9 36.2 3.8e-06 27.0 0.4 8.6 4 1 3 8 8 8 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001113437.2_49829001_1 - 2e-27 94.6 33.2 1.6e-06 27.7 2.0 7.5 5 2 0 7 7 7 5 Leucine rich repeat COR PF16095.3 001113437.2_49829001_1 - 1.3e-24 87.0 6.9 1.4e-24 86.9 0.2 3.1 4 0 0 4 4 3 1 C-terminal of Roc, COR, domain Ras PF00071.20 001113437.2_49829001_1 - 1.8e-15 56.8 0.0 4.3e-15 55.5 0.0 1.6 1 0 0 1 1 1 1 Ras family LRR_9 PF14580.4 001113437.2_49829001_1 - 6.5e-08 32.1 3.5 0.058 12.8 0.6 4.6 1 1 3 4 4 4 4 Leucine-rich repeat Arf PF00025.19 001113437.2_49829001_1 - 0.00012 21.5 1.7 0.00029 20.2 0.1 2.2 2 0 0 2 2 2 1 ADP-ribosylation factor family Ank_2 PF12796.5 001113437.2_49829001_1 - 0.0012 19.2 0.2 0.0061 17.0 0.2 2.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) G-alpha PF00503.18 001113437.2_49829001_1 - 0.0033 16.5 1.7 0.022 13.8 0.1 2.5 2 0 0 2 2 2 1 G-protein alpha subunit ABC_tran PF00005.25 001113437.2_49829001_1 - 0.0055 17.1 0.1 0.019 15.4 0.1 1.9 1 0 0 1 1 1 1 ABC transporter T2SSE PF00437.18 001113437.2_49829001_1 - 0.01 14.8 0.0 0.02 13.8 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_16 PF13191.4 001113437.2_49829001_1 - 0.011 16.0 0.0 0.037 14.3 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain Kdo PF06293.12 001113437.2_49829001_1 - 0.011 14.9 0.1 0.056 12.6 0.1 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family MMR_HSR1 PF01926.21 001113437.2_49829001_1 - 0.02 14.8 0.1 0.098 12.6 0.0 2.2 2 0 0 2 2 2 0 50S ribosome-binding GTPase NB-ARC PF00931.20 001113437.2_49829001_1 - 0.027 13.4 0.7 0.11 11.3 0.1 2.2 2 0 0 2 2 2 0 NB-ARC domain NACHT PF05729.10 001113437.2_49829001_1 - 0.028 14.2 0.5 0.096 12.5 0.5 1.9 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.4 001113437.2_49829001_1 - 0.028 14.5 0.0 0.12 12.5 0.0 2.1 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.7 001113437.2_49829001_1 - 0.039 13.6 0.5 0.16 11.6 0.5 2.0 2 0 0 2 2 1 0 Ethanolamine utilisation - propanediol utilisation TrwB_AAD_bind PF10412.7 001113437.2_49829001_1 - 0.053 12.3 0.0 0.1 11.4 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain MobB PF03205.12 001113437.2_49829001_1 - 0.058 13.2 0.2 0.13 12.1 0.2 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B FtsK_SpoIIIE PF01580.16 001113437.2_49829001_1 - 0.064 12.5 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family cobW PF02492.17 001113437.2_49829001_1 - 0.08 12.4 0.1 0.16 11.4 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Arm PF00514.21 001113437.2_49829001_1 - 0.093 12.7 2.5 0.3 11.0 0.2 3.2 4 0 0 4 4 3 0 Armadillo/beta-catenin-like repeat AAA_29 PF13555.4 001113437.2_49829001_1 - 0.12 11.9 0.0 0.3 10.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.4 001113437.2_49829001_1 - 0.3 11.4 1.7 0.69 10.2 0.0 2.5 2 0 0 2 2 1 0 AAA domain HlyIII PF03006.18 001044595.2_49826001_3 - 9.4e-17 61.3 23.8 1.5e-16 60.7 23.8 1.3 1 0 0 1 1 1 1 Haemolysin-III related Proteasome PF00227.24 213935.2_49823001_2 - 4.6e-47 159.8 0.4 5.6e-47 159.5 0.4 1.1 1 0 0 1 1 1 1 Proteasome subunit Homeobox PF00046.27 001141984.2_49825001_1 - 3.3e-21 74.7 6.1 6.9e-21 73.7 6.1 1.6 1 0 0 1 1 1 1 Homeobox domain MelC1 PF06236.9 001141984.2_49825001_3 - 0.44 10.5 5.2 0.15 12.0 1.3 2.2 2 0 0 2 2 2 0 Tyrosinase co-factor MelC1 PMP22_Claudin PF00822.18 001161644.2_49824001_2 - 1.6e-17 63.7 6.2 2.7e-17 63.0 6.2 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001161644.2_49824001_2 - 2e-07 30.8 11.9 1.1e-06 28.4 11.9 2.0 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction WHIM1 PF15612.4 001142834.2_49829001_1 - 9.3e-12 44.1 0.3 2e-11 43.0 0.3 1.5 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 PHD PF00628.27 001142834.2_49829001_1 - 4.4e-10 39.2 4.3 2e-09 37.0 4.3 2.3 1 0 0 1 1 1 1 PHD-finger Shadoo PF14999.4 001194653.1_29621001_1 - 1.3e-68 229.0 32.0 1.5e-68 228.8 32.0 1.0 1 0 0 1 1 1 1 Shadow of prion protein, neuroprotective DUF4235 PF14019.4 001194653.1_29621001_1 - 0.019 14.9 3.8 0.019 14.9 3.8 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF4235) Cpn60_TCP1 PF00118.22 001280151.1_39724001_1 - 2.6e-85 286.8 17.5 6.6e-85 285.4 17.5 1.6 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family 4HB_MCP_1 PF12729.5 001280151.1_39724001_1 - 0.75 9.2 4.5 2.1 7.7 1.3 2.2 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction Cpn60_TCP1 PF00118.22 001254716.1_49824001_1 - 1e-85 288.1 18.4 2.6e-85 286.8 18.4 1.6 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family PRY PF13765.4 001163649.2_49824001_2 - 2.5e-20 71.7 0.0 6.1e-20 70.4 0.0 1.7 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 001163649.2_49824001_2 - 3.5e-17 62.5 0.1 7.8e-17 61.4 0.1 1.5 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_4 PF15227.4 001163649.2_49824001_2 - 2.5e-10 40.2 8.7 2.5e-10 40.2 8.7 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001163649.2_49824001_2 - 2.6e-10 39.9 5.7 2.6e-10 39.9 5.7 2.3 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001163649.2_49824001_2 - 1.1e-09 38.2 1.6 1.1e-09 38.2 1.6 3.1 2 1 0 2 2 1 1 B-box zinc finger zf-RING_UBOX PF13445.4 001163649.2_49824001_2 - 1.6e-09 37.5 2.5 1.6e-09 37.5 2.5 3.6 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_2 PF13639.4 001163649.2_49824001_2 - 3.6e-09 36.6 6.7 3.6e-09 36.6 6.7 2.4 3 0 0 3 3 1 1 Ring finger domain zf-C3HC4_3 PF13920.4 001163649.2_49824001_2 - 6.5e-09 35.4 5.4 6.5e-09 35.4 5.4 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 001163649.2_49824001_2 - 7.7e-09 35.2 3.1 1.5e-08 34.2 3.1 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_2 PF13923.4 001163649.2_49824001_2 - 9.7e-09 34.8 6.6 9.7e-09 34.8 6.6 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001163649.2_49824001_2 - 4.7e-07 29.5 5.8 4.7e-07 29.5 5.8 2.5 2 1 0 2 2 2 1 zinc-RING finger domain zf-RING_4 PF14570.4 001163649.2_49824001_2 - 0.0003 20.3 4.1 0.0003 20.3 4.1 2.0 2 0 0 2 2 1 1 RING/Ubox like zinc-binding domain U-box PF04564.13 001163649.2_49824001_2 - 0.00077 19.4 0.0 0.0016 18.5 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.6 001163649.2_49824001_2 - 0.0018 18.0 1.8 0.0051 16.5 1.8 1.8 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.5 001163649.2_49824001_2 - 0.0019 18.3 3.1 0.0019 18.3 3.1 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_10 PF16685.3 001163649.2_49824001_2 - 0.0045 17.0 2.8 0.0045 17.0 2.8 2.3 2 0 0 2 2 2 1 zinc RING finger of MSL2 Prok-RING_4 PF14447.4 001163649.2_49824001_2 - 0.0047 16.6 8.1 0.0047 16.6 8.1 2.6 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_5 PF17121.3 001163649.2_49824001_2 - 0.066 13.0 5.3 0.2 11.4 5.3 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF313 PF03754.11 001163649.2_49824001_2 - 0.07 13.2 1.5 0.13 12.4 1.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF313) zf-RING_11 PF17123.3 001163649.2_49824001_2 - 0.09 12.4 8.4 0.19 11.3 6.7 2.6 2 0 0 2 2 2 0 RING-like zinc finger DUF4407 PF14362.4 001163649.2_49824001_2 - 0.28 10.3 13.5 0.39 9.9 13.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-ANAPC11 PF12861.5 001163649.2_49824001_2 - 0.35 10.8 5.7 0.11 12.4 1.9 2.2 2 0 0 2 2 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-UDP PF14569.4 001163649.2_49824001_2 - 0.47 10.5 8.3 0.15 12.1 3.9 2.4 2 1 0 2 2 2 0 Zinc-binding RING-finger Rtf2 PF04641.10 001163649.2_49824001_2 - 0.76 9.0 17.7 1.6e+02 1.4 17.7 2.3 1 1 0 1 1 1 0 Rtf2 RING-finger FAM76 PF16046.3 001163649.2_49824001_2 - 1 8.5 16.0 0.009 15.3 6.4 2.1 2 0 0 2 2 2 0 FAM76 protein Baculo_IE-1 PF05290.9 001163649.2_49824001_2 - 1.7 8.4 4.6 0.76 9.6 1.1 2.2 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) DUF3584 PF12128.6 001163649.2_49824001_2 - 3.6 4.9 17.4 4.8 4.4 17.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Exonuc_VII_L PF02601.13 001163649.2_49824001_2 - 3.7 6.9 9.0 5.2 6.4 9.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF342 PF03961.11 001163649.2_49824001_2 - 9.1 4.6 9.5 13 4.1 9.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Bromodomain PF00439.23 001260835.1_29628001_2 - 3.4e-21 75.0 0.2 8.2e-21 73.8 0.2 1.7 1 0 0 1 1 1 1 Bromodomain zf-B_box PF00643.22 001260835.1_29628001_2 - 4.8e-11 42.5 22.1 1.7e-09 37.5 7.3 5.1 6 0 0 6 6 6 2 B-box zinc finger PHD PF00628.27 001260835.1_29628001_2 - 1.1e-08 34.7 10.1 1.1e-08 34.7 10.1 5.1 5 0 0 5 5 5 1 PHD-finger zf-RING_UBOX PF13445.4 001260835.1_29628001_2 - 5.4e-05 23.0 5.0 5.4e-05 23.0 5.0 3.7 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.4 001260835.1_29628001_2 - 0.00082 19.2 8.8 0.00082 19.2 8.8 4.7 3 2 0 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.4 001260835.1_29628001_2 - 0.0023 18.0 2.9 0.0023 18.0 2.9 5.1 5 0 0 5 5 5 1 Ring finger domain zf-C3HC4 PF00097.23 001260835.1_29628001_2 - 0.0044 16.7 4.1 0.0044 16.7 4.1 4.3 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001260835.1_29628001_2 - 0.006 16.3 3.7 0.006 16.3 3.7 4.9 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) DUF4649 PF15507.4 001260835.1_29628001_2 - 0.024 14.4 0.0 0.063 13.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4649) Imm68 PF15583.4 001260835.1_29628001_2 - 0.43 10.6 2.7 0.82 9.7 2.7 1.4 1 0 0 1 1 1 0 Immunity protein 68 SNF2_N PF00176.21 001266774.1_29629001_3 - 7.3e-121 403.0 0.1 7.3e-121 403.0 0.1 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain Linker_histone PF00538.17 001266774.1_29629001_3 - 1.5e-17 63.6 0.0 5.6e-17 61.7 0.0 2.1 1 0 0 1 1 1 1 linker histone H1 and H5 family Helicase_C PF00271.29 001266774.1_29629001_3 - 5.8e-08 32.9 0.0 1.9e-07 31.3 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.27 001266774.1_29629001_3 - 3.2e-06 26.8 9.1 3.2e-06 26.8 9.1 3.6 3 1 0 3 3 2 1 PHD-finger zf-RING_UBOX PF13445.4 001266774.1_29629001_3 - 6.4e-05 22.8 7.2 6.4e-05 22.8 7.2 2.5 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 001266774.1_29629001_3 - 0.00017 21.2 10.3 0.00017 21.2 10.3 3.2 5 0 0 5 5 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001266774.1_29629001_3 - 0.0004 20.5 30.5 0.00051 20.1 10.9 4.1 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.23 001266774.1_29629001_3 - 0.00058 19.6 10.9 0.00058 19.6 10.9 3.5 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001266774.1_29629001_3 - 0.0026 17.5 10.4 0.0026 17.5 10.4 3.6 3 1 0 3 3 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.4 001266774.1_29629001_3 - 0.0028 17.3 5.0 0.0028 17.3 5.0 3.1 4 0 0 4 4 2 1 Zinc finger, C3HC4 type (RING finger) GIT1_C PF12205.6 001266774.1_29629001_3 - 0.58 10.1 4.3 0.33 10.9 0.1 2.8 3 0 0 3 3 2 0 G protein-coupled receptor kinase-interacting protein 1 C term Prok-RING_4 PF14447.4 001266774.1_29629001_3 - 2.2 8.1 16.9 0.27 11.0 10.0 3.2 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 PRY PF13765.4 001290243.1_22424001_3 - 1.8e-20 72.1 0.0 3.5e-20 71.2 0.0 1.5 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 001290243.1_22424001_3 - 1.2e-19 70.5 0.1 2.5e-19 69.4 0.1 1.5 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_4 PF15227.4 001290243.1_22424001_3 - 1.7e-10 40.7 8.8 1.7e-10 40.7 8.8 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001290243.1_22424001_3 - 1.9e-10 40.3 4.8 1.9e-10 40.3 4.8 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001290243.1_22424001_3 - 3.5e-09 36.5 3.9 3.5e-09 36.5 3.9 3.0 3 1 0 3 3 3 1 B-box zinc finger zf-RING_UBOX PF13445.4 001290243.1_22424001_3 - 5.8e-09 35.7 5.1 5.8e-09 35.7 5.1 3.5 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 001290243.1_22424001_3 - 8e-09 35.1 7.0 8e-09 35.1 7.0 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001290243.1_22424001_3 - 9.2e-08 32.1 7.3 9.2e-08 32.1 7.3 2.3 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.4 001290243.1_22424001_3 - 9.5e-08 31.7 5.5 9.5e-08 31.7 5.5 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001290243.1_22424001_3 - 7.7e-06 25.6 6.9 7.7e-06 25.6 6.9 2.5 2 1 0 2 2 2 1 zinc-RING finger domain zf-RING_6 PF14835.4 001290243.1_22424001_3 - 5.7e-05 22.8 3.2 0.00013 21.7 3.2 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_4 PF14570.4 001290243.1_22424001_3 - 0.00024 20.6 5.3 0.0015 18.1 5.6 2.2 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-Nse PF11789.6 001290243.1_22424001_3 - 0.0017 18.0 2.7 0.0038 16.9 2.7 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.5 001290243.1_22424001_3 - 0.0036 17.4 4.1 0.0036 17.4 4.1 2.2 2 0 0 2 2 1 1 RING-H2 zinc finger domain DUF3749 PF12568.6 001290243.1_22424001_3 - 0.0068 16.1 0.9 0.026 14.2 0.1 2.0 1 1 0 2 2 2 1 Acetyltransferase (GNAT) domain DUF313 PF03754.11 001290243.1_22424001_3 - 0.07 13.2 0.6 0.13 12.3 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF313) Thioredoxin_6 PF13848.4 001290243.1_22424001_3 - 0.12 12.2 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain Prok-RING_4 PF14447.4 001290243.1_22424001_3 - 0.4 10.4 18.4 0.3 10.9 11.6 3.6 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-C3HC4_5 PF17121.3 001290243.1_22424001_3 - 0.56 10.0 7.9 2.3 8.1 7.9 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-UDP PF14569.4 001290243.1_22424001_3 - 1.4 9.0 7.7 0.31 11.0 3.3 2.2 2 1 0 2 2 2 0 Zinc-binding RING-finger zf-RING_10 PF16685.3 001290243.1_22424001_3 - 2.5 8.1 7.0 0.66 10.0 2.7 2.2 2 0 0 2 2 2 0 zinc RING finger of MSL2 Serpin PF00079.18 214395.2_49823001_3 - 3.6e-120 401.5 1.5 4.1e-120 401.3 1.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF1266 PF06889.9 214395.2_49823001_3 - 0.019 14.9 0.0 0.034 14.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1266) Serpin PF00079.18 001348942.1_49823001_2 - 3.5e-120 401.6 1.5 4e-120 401.4 1.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF1266 PF06889.9 001348942.1_49823001_2 - 0.019 14.9 0.0 0.034 14.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1266) HMG_box PF00505.17 213843.2_49828001_1 - 2.2e-25 88.7 1.3 6.1e-25 87.3 1.3 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box Sox_N PF12444.6 213843.2_49828001_1 - 3e-25 89.0 0.2 3e-25 89.0 0.2 2.6 3 0 0 3 3 3 1 Sox developmental protein N terminal HMG_box_2 PF09011.8 213843.2_49828001_1 - 3.1e-10 40.4 1.1 7.4e-10 39.2 1.1 1.7 1 0 0 1 1 1 1 HMG-box domain BAR PF03114.16 001280010.1_39724001_1 - 1.2e-70 237.7 7.1 2.9e-70 236.5 7.1 1.6 1 1 0 1 1 1 1 BAR domain SH3_9 PF14604.4 001280010.1_39724001_1 - 1.1e-11 44.3 0.1 1.8e-10 40.4 0.0 2.3 2 0 0 2 2 2 1 Variant SH3 domain BAR_2 PF10455.7 001280010.1_39724001_1 - 3.8e-08 32.7 0.5 6.7e-08 31.9 0.5 1.3 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking SH3_1 PF00018.26 001280010.1_39724001_1 - 1e-07 31.3 0.0 1.8e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 001280010.1_39724001_1 - 2.3e-06 27.0 0.0 5.5e-06 25.8 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain BAR_3 PF16746.3 001280010.1_39724001_1 - 3.7e-05 23.4 5.7 0.0057 16.2 0.2 2.3 1 1 1 2 2 2 2 BAR domain of APPL family Methyltransf_2 PF00891.16 001280168.1_39725001_1 - 6.2e-60 202.1 0.0 1.2e-59 201.2 0.0 1.5 1 0 0 1 1 1 1 O-methyltransferase Maf PF02545.12 001280168.1_39725001_1 - 8.5e-55 185.0 0.0 1.5e-54 184.2 0.0 1.4 1 0 0 1 1 1 1 Maf-like protein Dimerisation2 PF16864.3 001280168.1_39725001_1 - 9e-32 108.8 0.3 2.4e-31 107.4 0.3 1.8 1 0 0 1 1 1 1 Dimerisation domain Methyltransf_23 PF13489.4 001280168.1_39725001_1 - 3.6e-06 26.9 0.0 7.3e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 001280168.1_39725001_1 - 1.9e-05 25.2 0.0 6.4e-05 23.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.10 001280168.1_39725001_1 - 0.0012 19.3 0.0 0.0029 18.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001280168.1_39725001_1 - 0.012 16.2 0.0 0.035 14.7 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain CD20 PF04103.13 214092.2_49828001_2 - 6.8e-23 81.3 13.3 1.4e-22 80.3 13.3 1.6 1 0 0 1 1 1 1 CD20-like family WBP-1 PF11669.6 001194587.2_29629001_2 - 1.1e-44 151.2 12.2 1.1e-44 151.2 12.2 2.6 2 0 0 2 2 2 1 WW domain-binding protein 1 Anth_Ig PF05587.11 001328278.1_39725001_3 - 7.8e-38 128.9 1.2 1.5e-37 128.0 1.2 1.4 1 0 0 1 1 1 1 Anthrax receptor extracellular domain VWA PF00092.26 001328278.1_39725001_3 - 3e-22 79.6 0.1 3.9e-22 79.2 0.1 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.4 001328278.1_39725001_3 - 2.2e-11 44.2 0.0 3.9e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain TIG PF01833.22 001328278.1_39725001_3 - 0.068 13.1 0.4 0.14 12.2 0.4 1.5 1 0 0 1 1 1 0 IPT/TIG domain ECH_1 PF00378.18 001280141.1_39724001_3 - 3.8e-29 101.6 0.0 5.2e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Chromo PF00385.22 001280141.1_39724001_3 - 1.5e-15 56.7 1.4 2.9e-15 55.8 1.4 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain ECH_2 PF16113.3 001280141.1_39724001_3 - 2.4e-11 43.6 0.0 3.3e-11 43.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Mtf2_C PF14061.4 001280141.1_39724001_3 - 0.056 13.5 0.8 0.12 12.4 0.8 1.5 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 XTBD PF11952.6 001280141.1_39724001_3 - 0.091 12.4 0.6 2.7 7.7 0.0 2.8 1 1 1 2 2 2 0 XRN-Two Binding Domain, XTBD HORMA PF02301.16 001195813.1_29622001_1 - 3.5e-23 82.2 0.5 5.4e-23 81.6 0.5 1.2 1 0 0 1 1 1 1 HORMA domain ATG101 PF07855.10 001195813.1_29622001_1 - 0.0014 18.5 0.4 0.026 14.4 0.4 2.2 1 1 0 1 1 1 1 Autophagy-related protein 101 ATG13 PF10033.7 001195813.1_29622001_1 - 0.077 12.5 0.1 0.086 12.3 0.1 1.2 1 0 0 1 1 1 0 Autophagy-related protein 13 4HBT_3 PF13622.4 001266088.1_29623001_3 - 7.6e-64 216.2 1.9 9.2e-64 215.9 1.9 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.13 001266088.1_29623001_3 - 4.4e-36 123.5 0.0 7.8e-27 93.6 0.0 3.1 2 1 0 2 2 2 2 Acyl-CoA thioesterase 4HBT PF03061.20 001266088.1_29623001_3 - 0.0034 17.6 0.2 0.25 11.6 0.0 2.3 2 0 0 2 2 2 1 Thioesterase superfamily IL8 PF00048.18 001032947.1_29621001_1 - 8.6e-14 51.3 0.2 8.6e-14 51.3 0.2 1.7 2 0 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like PHtD_u1 PF16645.3 001032947.1_29621001_1 - 0.029 14.7 1.1 0.043 14.1 1.1 1.3 1 0 0 1 1 1 0 Unstructured region on Pneumococcal histidine triad protein Fer4_2 PF12797.5 001032947.1_29621001_3 - 0.031 14.2 1.7 0.037 14.0 0.4 1.8 2 0 0 2 2 2 0 4Fe-4S binding domain WBS_methylT PF12589.6 001266959.1_29623001_1 - 3.4e-17 62.8 0.8 7.3e-17 61.8 0.8 1.6 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.10 001266959.1_29623001_1 - 9.1e-11 42.1 0.0 1.6e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 001266959.1_29623001_1 - 1.5e-10 41.5 0.0 3.1e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 001266959.1_29623001_1 - 0.00016 21.5 0.0 0.00023 21.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 001266959.1_29623001_1 - 0.00017 21.3 0.0 0.00025 20.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001266959.1_29623001_1 - 0.00019 22.0 0.0 0.00039 21.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.4 001266959.1_29623001_1 - 0.052 13.4 0.0 0.093 12.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain AdoMet_MTase PF07757.11 001266959.1_29623001_1 - 0.056 13.6 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase TehB PF03848.12 001266959.1_29623001_1 - 0.13 11.6 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB CwfJ_C_1 PF04677.13 001280224.1_39726001_1 - 2.2e-34 117.8 0.0 4.1e-34 116.9 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.12 001280224.1_39726001_1 - 2.4e-16 60.3 0.1 4.4e-16 59.4 0.1 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 Metallophos_3 PF14582.4 001280224.1_39726001_1 - 0.009 15.2 0.0 0.018 14.3 0.0 1.4 1 0 0 1 1 1 1 Metallophosphoesterase, calcineurin superfamily UFD1 PF03152.12 001257731.1_29624001_2 - 2.3e-79 264.7 0.0 3e-79 264.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 CASP_C PF08172.10 001168778.1_40422001_1 - 0.0015 17.8 0.1 0.002 17.4 0.1 1.3 1 0 0 1 1 1 1 CASP C terminal Macoilin PF09726.7 001168778.1_40422001_1 - 0.15 10.4 1.5 0.23 9.8 1.5 1.2 1 0 0 1 1 1 0 Transmembrane protein GIT_CC PF16559.3 001168778.1_40422001_1 - 0.85 9.6 3.3 0.73 9.8 0.6 2.0 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Ras PF00071.20 001126358.1_39522001_1 - 1.4e-39 135.2 0.1 1.8e-39 134.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001126358.1_39522001_1 - 2.3e-34 118.1 0.0 3.7e-34 117.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001126358.1_39522001_1 - 3.4e-12 46.0 0.0 5.9e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001126358.1_39522001_1 - 2.2e-07 30.3 0.0 3.9e-07 29.5 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001126358.1_39522001_1 - 8.6e-07 28.5 0.3 2.2e-05 23.9 0.1 2.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001126358.1_39522001_1 - 1e-05 25.5 0.0 2.3e-05 24.3 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.8 001126358.1_39522001_1 - 0.0012 18.2 0.0 0.0017 17.7 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit DUF258 PF03193.14 001126358.1_39522001_1 - 0.0095 15.7 0.0 4.8 6.9 0.0 2.4 1 1 1 2 2 2 2 Protein of unknown function, DUF258 G-alpha PF00503.18 001126358.1_39522001_1 - 0.013 14.6 0.2 0.031 13.3 0.2 1.8 1 1 0 1 1 1 0 G-protein alpha subunit ATP_bind_1 PF03029.15 001126358.1_39522001_1 - 0.03 13.9 0.1 0.064 12.9 0.1 1.5 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein MMR_HSR1_Xtn PF16897.3 001126358.1_39522001_1 - 0.053 13.4 0.0 0.094 12.6 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain AAA_22 PF13401.4 001126358.1_39522001_1 - 0.06 13.5 0.1 1.3 9.1 0.1 2.6 1 1 0 1 1 1 0 AAA domain MHC_I PF00129.16 001318351.1_29623001_1 - 5.7e-93 309.3 1.5 9e-93 308.7 1.5 1.3 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001318351.1_29623001_1 - 6.9e-17 61.6 0.0 1.3e-16 60.7 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001318351.1_29623001_1 - 1.4e-12 47.1 2.2 2.7e-12 46.3 2.2 1.5 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 001318351.1_29623001_1 - 1e-05 25.9 1.8 0.019 15.5 0.0 2.6 2 1 1 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.10 001318351.1_29623001_1 - 0.00052 19.9 0.1 0.0011 18.9 0.1 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001318351.1_29623001_1 - 0.0068 16.4 0.1 0.014 15.4 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain DUF4527 PF15030.4 001328318.1_39726001_3 - 0.023 14.1 3.9 0.047 13.0 3.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4527) DUF2046 PF09755.7 001328318.1_39726001_3 - 0.048 12.7 2.1 0.078 12.1 2.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) HALZ PF02183.16 001328318.1_39726001_3 - 0.13 12.3 3.4 0.081 13.0 1.2 1.8 2 0 0 2 2 2 0 Homeobox associated leucine zipper IncA PF04156.12 001328318.1_39726001_3 - 0.15 11.7 1.4 0.3 10.7 1.4 1.4 1 0 0 1 1 1 0 IncA protein FlxA PF14282.4 001328318.1_39726001_3 - 2.4 8.1 7.5 0.12 12.2 1.2 2.1 2 0 0 2 2 2 0 FlxA-like protein FUSC PF04632.10 001328318.1_39726001_3 - 2.4 6.5 5.7 3.6 5.9 5.7 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family ADIP PF11559.6 001328318.1_39726001_3 - 9.1 6.2 7.7 0.4 10.6 2.1 1.5 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding CwfJ_C_1 PF04677.13 001142831.1_49827001_3 - 7.2e-39 132.3 0.6 1.7e-38 131.1 0.6 1.7 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.12 001142831.1_49827001_3 - 6.4e-31 107.0 0.2 6.4e-31 107.0 0.2 3.5 5 0 0 5 5 5 1 Protein similar to CwfJ C-terminus 2 PRY PF13765.4 001290237.1_22424001_3 - 3.1e-17 61.8 0.1 6e-17 60.9 0.1 1.5 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 001290237.1_22424001_3 - 1.2e-15 57.5 0.0 3e-15 56.3 0.0 1.6 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_4 PF15227.4 001290237.1_22424001_3 - 2.5e-10 40.2 9.6 2.5e-10 40.2 9.6 2.6 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.22 001290237.1_22424001_3 - 6.1e-09 35.8 2.3 6.1e-09 35.8 2.3 3.2 2 1 0 2 2 1 1 B-box zinc finger zf-RING_UBOX PF13445.4 001290237.1_22424001_3 - 2.6e-08 33.6 2.3 2.6e-08 33.6 2.3 3.1 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001290237.1_22424001_3 - 2.5e-06 27.1 9.3 2.5e-06 27.1 9.3 2.4 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001290237.1_22424001_3 - 5.6e-06 26.4 8.5 5.6e-06 26.4 8.5 2.6 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.4 001290237.1_22424001_3 - 1.3e-05 24.8 6.3 1.3e-05 24.8 6.3 2.5 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) U-box PF04564.13 001290237.1_22424001_3 - 2.4e-05 24.3 0.3 0.00011 22.2 0.0 2.2 2 0 0 2 2 2 1 U-box domain zf-C3HC4_2 PF13923.4 001290237.1_22424001_3 - 0.00024 20.7 9.7 0.00024 20.7 9.7 2.7 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Atg14 PF10186.7 001290237.1_22424001_3 - 0.00044 19.3 20.4 0.00044 19.3 20.4 1.9 2 0 0 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 Trm112p PF03966.14 001290237.1_22424001_3 - 0.0016 18.8 2.8 0.0044 17.4 0.8 2.8 3 0 0 3 3 3 1 Trm112p-like protein zf-RING_4 PF14570.4 001290237.1_22424001_3 - 0.0059 16.2 2.8 0.022 14.3 2.8 2.0 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.4 001290237.1_22424001_3 - 0.0097 15.6 2.7 0.078 12.7 2.7 2.4 1 1 0 1 1 1 1 zf-RING of BARD1-type protein DUF4618 PF15397.4 001290237.1_22424001_3 - 0.011 15.0 4.1 0.011 15.0 4.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4618) Flagellin_N PF00669.18 001290237.1_22424001_3 - 0.013 15.4 0.8 0.013 15.4 0.8 2.0 2 0 0 2 2 2 0 Bacterial flagellin N-terminal helical region zf-RING_5 PF14634.4 001290237.1_22424001_3 - 0.017 14.9 7.9 0.017 14.9 7.9 3.3 2 2 0 2 2 2 0 zinc-RING finger domain zf-Nse PF11789.6 001290237.1_22424001_3 - 0.028 14.1 7.0 0.09 12.5 4.9 2.7 3 0 0 3 3 3 0 Zinc-finger of the MIZ type in Nse subunit FliD_C PF07195.10 001290237.1_22424001_3 - 0.03 13.6 0.3 0.03 13.6 0.3 2.1 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Fib_alpha PF08702.8 001290237.1_22424001_3 - 0.1 12.7 17.0 0.2 11.7 17.0 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family RDM PF11002.6 001290237.1_22424001_3 - 0.12 12.2 1.5 0.13 12.1 0.0 1.8 2 0 0 2 2 1 0 RFPL defining motif (RDM) DUF4407 PF14362.4 001290237.1_22424001_3 - 0.3 10.3 10.5 0.019 14.2 4.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) zf-RING_10 PF16685.3 001290237.1_22424001_3 - 0.34 11.0 11.3 0.039 14.0 5.3 2.7 2 1 0 2 2 2 0 zinc RING finger of MSL2 FANCL_C PF11793.6 001290237.1_22424001_3 - 0.41 10.7 14.6 0.037 14.1 6.8 3.1 3 1 0 3 3 3 0 FANCL C-terminal domain Gp-FAR-1 PF05823.10 001290237.1_22424001_3 - 1.3 9.1 14.4 0.14 12.3 2.3 2.9 2 1 1 3 3 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) LMBR1 PF04791.14 001290237.1_22424001_3 - 1.4 7.6 7.0 1.8 7.2 7.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein IBR PF01485.19 001290237.1_22424001_3 - 2.7 8.2 15.6 0.18 11.9 3.3 3.1 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain ApoLp-III PF07464.9 001290237.1_22424001_3 - 3.2 7.7 16.7 34 4.4 15.7 2.3 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Prok-RING_4 PF14447.4 001290237.1_22424001_3 - 5.2 6.9 14.7 0.24 11.2 7.6 2.5 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 Cob_adeno_trans PF01923.16 001290237.1_22424001_3 - 5.7 6.9 8.5 2.3 8.2 1.8 2.4 2 1 1 3 3 2 0 Cobalamin adenosyltransferase PRY PF13765.4 001290247.1_22423001_1 - 5.2e-17 61.1 0.0 1.2e-16 59.9 0.0 1.7 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 001290247.1_22423001_1 - 4.2e-15 55.8 0.1 7e-15 55.1 0.1 1.3 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_4 PF15227.4 001290247.1_22423001_1 - 6.2e-10 38.9 7.6 6.2e-10 38.9 7.6 1.9 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 001290247.1_22423001_1 - 3.2e-09 36.5 4.1 4.6e-09 36.0 3.0 1.9 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001290247.1_22423001_1 - 4.4e-09 35.9 6.8 1.2e-08 34.6 6.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001290247.1_22423001_1 - 1.6e-06 27.7 6.8 3.9e-06 26.5 6.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001290247.1_22423001_1 - 2.4e-06 27.5 8.3 2.4e-06 27.5 8.3 2.0 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.4 001290247.1_22423001_1 - 1.7e-05 24.4 5.6 1.7e-05 24.4 5.6 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001290247.1_22423001_1 - 1.7e-05 24.7 0.9 1.7e-05 24.7 0.9 3.4 4 0 0 4 4 2 1 B-box zinc finger zf-RING_5 PF14634.4 001290247.1_22423001_1 - 2.4e-05 24.1 6.8 5.9e-05 22.8 6.8 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_6 PF14835.4 001290247.1_22423001_1 - 0.00016 21.3 5.1 0.00036 20.2 5.1 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein DUF3416 PF11896.6 001290247.1_22423001_1 - 0.0021 18.3 5.9 0.0026 18.0 3.2 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF3416) zf-RING_10 PF16685.3 001290247.1_22423001_1 - 0.0026 17.7 3.4 0.0064 16.5 3.4 1.6 1 0 0 1 1 1 1 zinc RING finger of MSL2 CorA PF01544.16 001290247.1_22423001_1 - 0.003 16.8 7.4 0.0046 16.2 7.4 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein KxDL PF10241.7 001290247.1_22423001_1 - 0.0054 16.8 11.3 0.02 15.0 1.7 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein Prok-RING_4 PF14447.4 001290247.1_22423001_1 - 0.013 15.2 5.9 0.013 15.2 5.9 1.9 2 0 0 2 2 1 0 Prokaryotic RING finger family 4 LXG PF04740.10 001290247.1_22423001_1 - 0.014 15.0 2.3 0.014 15.0 2.3 2.2 2 0 0 2 2 2 0 LXG domain of WXG superfamily zf-ANAPC11 PF12861.5 001290247.1_22423001_1 - 0.019 14.9 2.4 0.06 13.3 2.4 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger U-box PF04564.13 001290247.1_22423001_1 - 0.02 15.0 0.0 0.046 13.8 0.0 1.6 1 0 0 1 1 1 0 U-box domain AAA_13 PF13166.4 001290247.1_22423001_1 - 0.02 13.4 5.6 0.027 13.0 5.6 1.1 1 0 0 1 1 1 0 AAA domain Ribosomal_L37ae PF01780.17 001290247.1_22423001_1 - 0.021 14.8 1.5 0.039 13.9 0.2 2.1 3 0 0 3 3 1 0 Ribosomal L37ae protein family Gp-FAR-1 PF05823.10 001290247.1_22423001_1 - 0.034 14.3 2.9 0.2 11.9 2.6 2.2 2 1 1 3 3 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Phasin PF05597.9 001290247.1_22423001_1 - 0.049 13.5 8.2 0.098 12.6 8.2 1.5 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF1664 PF07889.10 001290247.1_22423001_1 - 0.05 13.5 8.1 0.62 9.9 1.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Atg14 PF10186.7 001290247.1_22423001_1 - 0.053 12.5 7.6 0.096 11.6 7.6 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 zf-Nse PF11789.6 001290247.1_22423001_1 - 0.063 13.0 1.9 0.12 12.1 1.9 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Fib_alpha PF08702.8 001290247.1_22423001_1 - 0.07 13.2 8.2 0.13 12.3 7.1 1.9 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Exonuc_VII_L PF02601.13 001290247.1_22423001_1 - 0.1 12.0 8.1 0.14 11.6 8.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit V_ATPase_I PF01496.17 001290247.1_22423001_1 - 0.13 10.0 4.9 0.18 9.5 4.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Prominin PF05478.9 001290247.1_22423001_1 - 0.2 9.5 2.5 0.28 9.0 2.5 1.1 1 0 0 1 1 1 0 Prominin TMPIT PF07851.11 001290247.1_22423001_1 - 0.2 10.7 6.3 0.3 10.1 6.3 1.2 1 0 0 1 1 1 0 TMPIT-like protein zf-rbx1 PF12678.5 001290247.1_22423001_1 - 0.22 11.7 6.6 0.6 10.3 6.6 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain PilJ PF13675.4 001290247.1_22423001_1 - 0.24 11.3 8.6 0.97 9.4 8.5 2.0 1 1 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term Spc24 PF08286.9 001290247.1_22423001_1 - 0.34 11.0 10.1 0.19 11.8 1.0 2.4 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Laminin_II PF06009.10 001290247.1_22423001_1 - 0.35 10.7 8.3 4.2 7.3 2.9 2.2 1 1 1 2 2 2 0 Laminin Domain II Uso1_p115_C PF04871.11 001290247.1_22423001_1 - 0.39 11.0 15.5 0.64 10.3 15.5 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF3584 PF12128.6 001290247.1_22423001_1 - 0.65 7.3 15.6 0.85 6.9 15.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Apolipoprotein PF01442.16 001290247.1_22423001_1 - 0.66 9.7 20.3 7.9 6.2 8.0 2.1 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain AAA_32 PF13654.4 001290247.1_22423001_1 - 0.75 8.4 12.9 2.4 6.7 6.4 2.1 1 1 1 2 2 2 0 AAA domain LMBR1 PF04791.14 001290247.1_22423001_1 - 1.1 8.0 2.8 1.4 7.6 2.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4337 PF14235.4 001290247.1_22423001_1 - 1.1 9.2 6.7 0.19 11.7 2.8 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) DUF4665 PF15679.3 001290247.1_22423001_1 - 1.4 9.4 3.3 7.5 7.1 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4665) Baculo_PEP_C PF04513.10 001290247.1_22423001_1 - 1.6 8.6 6.9 5.4 6.9 0.8 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.9 001290247.1_22423001_1 - 1.6 7.4 15.1 2.8 6.6 15.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Snapin_Pallidin PF14712.4 001290247.1_22423001_1 - 1.9 8.9 15.6 0.13 12.6 8.2 2.3 1 1 1 2 2 2 0 Snapin/Pallidin Reo_sigmaC PF04582.10 001290247.1_22423001_1 - 2 7.6 4.4 10 5.3 2.3 2.4 2 1 1 3 3 3 0 Reovirus sigma C capsid protein NPA PF16469.3 001290247.1_22423001_1 - 2.4 8.7 6.9 0.9 10.1 0.6 2.2 1 1 0 1 1 1 0 Nematode polyprotein allergen ABA-1 Spore_III_AB PF09548.8 001290247.1_22423001_1 - 2.5 8.1 10.7 2 8.4 9.1 1.6 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) MbeD_MobD PF04899.10 001290247.1_22423001_1 - 2.9 8.0 12.7 3.7e+02 1.2 12.1 2.6 1 1 0 1 1 1 0 MbeD/MobD like XhlA PF10779.7 001290247.1_22423001_1 - 4.8 7.3 5.0 25 5.0 0.3 2.5 2 0 0 2 2 2 0 Haemolysin XhlA TBCA PF02970.14 001290247.1_22423001_1 - 5.4 7.3 11.7 2.2 8.5 6.3 2.2 1 1 1 2 2 2 0 Tubulin binding cofactor A Mnd1 PF03962.13 001290247.1_22423001_1 - 5.9 6.6 15.4 8.3 6.1 1.3 2.1 1 1 1 2 2 2 0 Mnd1 family DUF342 PF03961.11 001290247.1_22423001_1 - 6.4 5.1 10.3 18 3.6 10.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF342) Syntaxin-6_N PF09177.9 001290247.1_22423001_1 - 7.4 7.1 8.1 59 4.2 8.0 2.2 1 1 0 1 1 1 0 Syntaxin 6, N-terminal DUF16 PF01519.14 001290247.1_22423001_1 - 7.8 6.9 10.7 1.8 8.9 1.3 2.4 1 1 0 2 2 2 0 Protein of unknown function DUF16 DUF4795 PF16043.3 001290247.1_22423001_1 - 8 5.9 13.0 4.4 6.7 6.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) TBPIP PF07106.11 001290247.1_22423001_1 - 8.1 6.0 12.2 3.9 7.1 6.2 2.1 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) FUSC PF04632.10 001290247.1_22423001_1 - 9.8 4.4 9.8 18 3.6 9.8 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family zf-C3HC4_2 PF13923.4 001328306.1_39725001_3 - 1e-06 28.3 14.2 3.6e-06 26.6 14.2 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 001328306.1_39725001_3 - 1.7e-06 27.6 9.9 1.7e-06 27.6 9.9 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.23 001328306.1_39725001_3 - 3e-06 26.9 13.7 3e-06 26.9 13.7 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001328306.1_39725001_3 - 7.2e-06 25.6 13.7 7.2e-06 25.6 13.7 2.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001328306.1_39725001_3 - 8.4e-06 25.6 11.3 5e-05 23.1 11.3 2.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.4 001328306.1_39725001_3 - 3.4e-05 23.6 12.1 0.00017 21.3 12.1 2.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.4 001328306.1_39725001_3 - 0.00014 21.8 15.2 0.00057 19.8 15.2 2.1 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.4 001328306.1_39725001_3 - 0.0017 18.5 16.5 0.0017 18.5 16.5 2.5 3 0 0 3 3 3 1 Ring finger domain zf-RING_10 PF16685.3 001328306.1_39725001_3 - 0.11 12.5 9.6 0.38 10.8 9.6 1.9 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_4 PF14570.4 001328306.1_39725001_3 - 0.61 9.7 12.4 0.036 13.7 5.8 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_2 PF13639.4 001266180.1_29627001_3 - 3.8e-06 26.9 8.8 3.8e-06 26.9 8.8 2.7 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.4 001266180.1_29627001_3 - 7e-05 22.6 10.0 7e-05 22.6 10.0 2.7 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4 PF00097.23 001266180.1_29627001_3 - 0.0062 16.3 10.1 0.0062 16.3 10.1 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001131724.1_43525001_2 - 2.7e-13 49.8 8.2 2.7e-13 49.8 8.2 2.1 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.3 001131724.1_43525001_2 - 1.6e-11 43.5 3.9 1.6e-11 43.5 3.9 2.1 2 0 0 2 2 2 1 RING-like zinc finger PA PF02225.20 001131724.1_43525001_2 - 3.4e-09 36.6 0.0 8.3e-09 35.3 0.0 1.7 1 0 0 1 1 1 1 PA domain zf-C3HC4_2 PF13923.4 001131724.1_43525001_2 - 1.7e-08 34.0 8.9 4e-08 32.8 8.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001131724.1_43525001_2 - 3e-08 33.3 8.4 6.5e-08 32.2 8.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001131724.1_43525001_2 - 6.5e-06 25.9 6.9 1.5e-05 24.7 6.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 001131724.1_43525001_2 - 6.7e-06 25.7 6.3 1.8e-05 24.3 6.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 001131724.1_43525001_2 - 1.5e-05 25.1 9.8 6.3e-05 23.1 9.8 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.4 001131724.1_43525001_2 - 0.00024 20.9 4.8 0.00026 20.8 2.2 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.5 001131724.1_43525001_2 - 0.0052 16.7 5.7 0.014 15.3 5.7 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.4 001131724.1_43525001_2 - 0.0062 16.2 6.7 0.0062 16.2 6.7 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 STAC2_u1 PF16664.3 001131724.1_43525001_2 - 0.096 13.0 0.9 0.19 12.1 0.9 1.4 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Neur_chan_memb PF02932.14 001131724.1_43525001_2 - 0.1 12.5 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PHD PF00628.27 001131724.1_43525001_2 - 0.23 11.2 8.6 0.59 9.9 8.6 1.7 1 0 0 1 1 1 0 PHD-finger zf-RING_4 PF14570.4 001131724.1_43525001_2 - 1.3 8.7 8.8 3 7.5 8.8 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_2 PF13639.4 001283484.1_29526001_2 - 2.7e-10 40.2 10.4 2.7e-10 40.2 10.4 1.9 2 0 0 2 2 1 1 Ring finger domain zf-RING_11 PF17123.3 001283484.1_29526001_2 - 4.2e-09 35.8 5.5 4.2e-09 35.8 5.5 2.0 2 0 0 2 2 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.4 001283484.1_29526001_2 - 1.2e-07 31.3 10.4 3.4e-07 29.9 10.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001283484.1_29526001_2 - 6.1e-06 25.9 8.6 1.7e-05 24.4 8.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001283484.1_29526001_2 - 1.2e-05 25.0 5.5 4.4e-05 23.3 5.5 2.0 1 1 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.5 001283484.1_29526001_2 - 1.4e-05 25.1 11.7 3.7e-05 23.8 11.7 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.4 001283484.1_29526001_2 - 2.8e-05 23.9 8.4 8.2e-05 22.4 8.4 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 001283484.1_29526001_2 - 0.0019 17.9 12.4 0.0041 16.8 12.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 001283484.1_29526001_2 - 0.0071 16.2 8.8 0.017 15.1 8.8 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.4 001283484.1_29526001_2 - 1.4 8.7 6.7 3.3 7.5 6.7 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Zn_ribbon_17 PF17120.3 001283484.1_29526001_2 - 1.4 8.4 13.2 3.1 7.4 13.2 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type SPRY PF00622.26 001171472.1_37923001_1 - 2.2e-11 43.8 0.1 4.4e-11 42.8 0.1 1.5 1 0 0 1 1 1 1 SPRY domain zf-RING_UBOX PF13445.4 001171472.1_37923001_1 - 6.9e-11 41.9 4.8 6.9e-11 41.9 4.8 3.2 2 1 1 3 3 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 001171472.1_37923001_1 - 6.3e-10 38.9 12.1 6.3e-10 38.9 12.1 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.22 001171472.1_37923001_1 - 1.4e-09 37.8 3.2 1.4e-09 37.8 3.2 3.5 3 1 0 3 3 3 1 B-box zinc finger zf-C3HC4 PF00097.23 001171472.1_37923001_1 - 9.7e-08 31.6 10.7 3.3e-07 29.9 10.7 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PRY PF13765.4 001171472.1_37923001_1 - 3.8e-07 29.5 0.0 9.5e-07 28.2 0.0 1.8 1 0 0 1 1 1 1 SPRY-associated domain zf-C3HC4_2 PF13923.4 001171472.1_37923001_1 - 8.3e-07 28.6 13.1 2.3e-06 27.2 9.6 3.1 2 1 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001171472.1_37923001_1 - 3e-05 23.8 8.2 3e-05 23.8 8.2 2.7 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.4 001171472.1_37923001_1 - 3.6e-05 23.8 11.0 3.6e-05 23.8 11.0 2.4 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.4 001171472.1_37923001_1 - 6.1e-05 22.7 8.3 6.1e-05 22.7 8.3 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.3 001171472.1_37923001_1 - 0.024 14.6 5.2 0.024 14.6 5.2 2.5 3 0 0 3 3 3 0 zinc RING finger of MSL2 Baculo_IE-1 PF05290.9 001171472.1_37923001_1 - 0.032 14.1 1.8 0.11 12.4 1.8 1.9 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_6 PF14835.4 001171472.1_37923001_1 - 0.12 12.1 10.5 0.045 13.5 6.3 2.5 2 1 0 2 2 2 0 zf-RING of BARD1-type protein zf-Nse PF11789.6 001171472.1_37923001_1 - 0.2 11.4 5.8 0.64 9.8 5.8 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit OmpH PF03938.12 001171472.1_37923001_1 - 0.23 11.3 20.3 0.38 10.6 20.3 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Annexin PF00191.18 001171472.1_37923001_1 - 0.29 11.1 2.9 0.42 10.6 0.3 2.5 2 1 0 2 2 2 0 Annexin Exonuc_VII_L PF02601.13 001171472.1_37923001_1 - 4.3 6.7 9.5 6.2 6.1 9.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Baculo_p24 PF05073.10 001171472.1_37923001_1 - 4.9 6.7 5.7 3.6 7.2 0.1 2.2 1 1 1 2 2 2 0 Baculovirus P24 capsid protein Caldesmon PF02029.13 001171472.1_37923001_1 - 6.2 5.3 19.1 8.8 4.8 19.1 1.1 1 0 0 1 1 1 0 Caldesmon Fib_alpha PF08702.8 001171472.1_37923001_1 - 7.3 6.6 16.7 0.24 11.5 10.5 1.7 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4407 PF14362.4 001171472.1_37923001_1 - 7.9 5.6 9.1 11 5.1 9.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF342 PF03961.11 001171472.1_37923001_1 - 7.9 4.8 10.0 13 4.1 10.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) TMPIT PF07851.11 001171472.1_37923001_1 - 8.2 5.4 11.8 16 4.5 11.8 1.4 1 0 0 1 1 1 0 TMPIT-like protein TBCC PF07986.10 001267788.1_29626001_2 - 1.6e-45 153.6 5.9 2.6e-45 152.9 5.9 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.9 001267788.1_29626001_2 - 2.1e-05 24.1 0.5 3.7e-05 23.3 0.5 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal NDK PF00334.17 001267788.1_29626001_2 - 0.075 12.9 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Nucleoside diphosphate kinase AP3D1 PF06375.9 001280167.2_39724001_2 - 9 6.4 14.4 14 5.8 14.4 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 PRY PF13765.4 001280167.2_39724001_3 - 2.2e-19 68.6 0.0 4e-19 67.8 0.0 1.5 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 001280167.2_39724001_3 - 1.3e-16 60.6 0.0 2.3e-16 59.9 0.0 1.3 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_4 PF15227.4 001280167.2_39724001_3 - 1.3e-12 47.5 8.0 1.3e-12 47.5 8.0 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001280167.2_39724001_3 - 1.5e-09 37.4 6.6 4.4e-09 35.9 6.6 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001280167.2_39724001_3 - 1.7e-08 34.2 8.8 6.2e-08 32.4 8.8 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 001280167.2_39724001_3 - 8.4e-08 31.8 9.9 3.1e-07 30.0 9.9 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001280167.2_39724001_3 - 2.6e-05 23.8 9.1 2.6e-05 23.8 9.1 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001280167.2_39724001_3 - 5.1e-05 23.0 7.6 5.1e-05 23.0 7.6 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 001280167.2_39724001_3 - 0.0002 21.4 10.0 0.0002 21.4 10.0 2.1 2 0 0 2 2 1 1 Ring finger domain zf-Nse PF11789.6 001280167.2_39724001_3 - 0.0057 16.3 3.0 0.029 14.1 3.0 2.2 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.4 001280167.2_39724001_3 - 0.051 13.3 6.8 0.16 11.7 6.8 1.8 1 1 0 1 1 1 0 zf-RING of BARD1-type protein Baculo_IE-1 PF05290.9 001280167.2_39724001_3 - 0.13 12.1 6.6 0.38 10.6 6.6 1.8 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-B_box PF00643.22 001280167.2_39724001_3 - 0.67 10.0 0.1 0.67 10.0 0.1 3.4 3 1 0 3 3 3 0 B-box zinc finger zf-RING_10 PF16685.3 001280167.2_39724001_3 - 1.4 9.0 12.4 0.22 11.6 8.2 1.9 2 0 0 2 2 1 0 zinc RING finger of MSL2 Prok-RING_4 PF14447.4 001280167.2_39724001_3 - 1.4 8.7 14.6 0.33 10.7 9.6 2.5 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.5 001280167.2_39724001_3 - 3.7 7.8 11.2 15 5.8 11.2 2.1 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.5 001280167.2_39724001_3 - 5.9 6.9 9.1 1.8 8.6 5.6 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.4 001280416.1_39724001_1 - 4.4e-14 52.3 4.7 8.4e-14 51.4 4.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.3 001280416.1_39724001_1 - 6.9e-12 44.7 1.7 1.8e-11 43.4 0.6 2.3 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.4 001280416.1_39724001_1 - 1.5e-09 37.4 4.5 3e-09 36.5 4.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001280416.1_39724001_1 - 1.4e-08 34.4 3.5 2.6e-08 33.5 3.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PA PF02225.20 001280416.1_39724001_1 - 2.1e-08 34.0 0.0 4.3e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 PA domain zf-RING_5 PF14634.4 001280416.1_39724001_1 - 1.1e-07 31.6 2.8 2.2e-07 30.6 2.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.5 001280416.1_39724001_1 - 1.3e-06 28.5 6.2 4.6e-06 26.7 6.2 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.4 001280416.1_39724001_1 - 3.7e-06 26.7 3.7 5.1e-05 23.1 0.4 2.7 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 001280416.1_39724001_1 - 4.1e-06 26.4 3.3 7.3e-06 25.6 3.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 001280416.1_39724001_1 - 0.00035 20.3 4.1 0.0008 19.1 4.1 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.5 001280416.1_39724001_1 - 0.0014 18.5 3.8 0.0053 16.7 3.8 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger PHD PF00628.27 001280416.1_39724001_1 - 0.056 13.2 3.7 0.12 12.2 3.7 1.6 1 0 0 1 1 1 0 PHD-finger RINGv PF12906.5 001280416.1_39724001_1 - 0.097 12.7 3.9 0.23 11.5 3.9 1.7 1 0 0 1 1 1 0 RING-variant domain Zn_ribbon_17 PF17120.3 001280416.1_39724001_1 - 0.11 12.0 2.9 0.22 11.0 2.9 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3H2C3 PF17122.3 001280416.1_39724001_1 - 0.34 10.9 3.3 0.89 9.5 3.3 1.7 1 0 0 1 1 1 0 Zinc-finger zf-RING_4 PF14570.4 001280416.1_39724001_1 - 0.41 10.3 5.2 1.1 8.9 5.2 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.9 001280416.1_39724001_1 - 0.66 10.2 3.9 1.4 9.1 3.9 1.6 1 0 0 1 1 1 0 RING-like domain FANCL_C PF11793.6 001280416.1_39724001_1 - 1.1 9.3 5.6 5.7 7.1 5.6 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_2 PF13639.4 001266577.1_29627001_3 - 3.2e-10 40.0 10.4 3.2e-10 40.0 10.4 1.9 2 0 0 2 2 1 1 Ring finger domain zf-RING_11 PF17123.3 001266577.1_29627001_3 - 5e-09 35.6 5.5 5e-09 35.6 5.5 2.0 2 0 0 2 2 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.4 001266577.1_29627001_3 - 1.6e-07 30.9 10.4 4.1e-07 29.6 10.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001266577.1_29627001_3 - 8.1e-06 25.5 8.6 2.1e-05 24.2 8.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001266577.1_29627001_3 - 1.8e-05 24.5 5.6 5.9e-05 22.9 5.6 1.9 1 1 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.5 001266577.1_29627001_3 - 1.8e-05 24.8 11.7 4.5e-05 23.5 11.7 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.4 001266577.1_29627001_3 - 3.7e-05 23.5 8.4 9.9e-05 22.1 8.4 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 001266577.1_29627001_3 - 0.0024 17.6 12.4 0.005 16.5 12.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 001266577.1_29627001_3 - 0.0089 15.9 8.8 0.02 14.8 8.8 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.4 001266577.1_29627001_3 - 1.7 8.4 6.7 4 7.3 6.7 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Zn_ribbon_17 PF17120.3 001266577.1_29627001_3 - 1.8 8.1 13.2 3.8 7.1 13.2 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.4 001113396.1_39723001_1 - 1.2e-11 44.3 6.9 3e-11 43.0 4.2 2.6 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 001113396.1_39723001_1 - 3.9e-11 42.8 8.6 3.9e-11 42.8 8.6 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001113396.1_39723001_1 - 4.9e-10 39.0 7.6 1.3e-09 37.7 7.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001113396.1_39723001_1 - 7.8e-09 35.1 7.2 1.4e-07 31.0 8.3 2.4 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001113396.1_39723001_1 - 3.7e-08 33.3 1.3 3.7e-08 33.3 1.3 3.1 3 1 0 3 3 3 1 B-box zinc finger SPRY PF00622.26 001113396.1_39723001_1 - 7.8e-08 32.3 0.2 1.9e-07 31.1 0.2 1.6 1 0 0 1 1 1 1 SPRY domain zf-RING_2 PF13639.4 001113396.1_39723001_1 - 7.2e-07 29.2 7.4 7.2e-07 29.2 7.4 2.2 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.4 001113396.1_39723001_1 - 1.1e-06 28.3 5.6 1.1e-06 28.3 5.6 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 001113396.1_39723001_1 - 3.9e-06 26.5 5.4 3.9e-06 26.5 5.4 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 001113396.1_39723001_1 - 0.00092 18.9 4.8 0.004 16.9 4.8 2.1 1 1 0 1 1 1 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.4 001113396.1_39723001_1 - 0.0011 18.7 8.9 0.025 14.3 9.8 2.6 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-Nse PF11789.6 001113396.1_39723001_1 - 0.0038 16.9 4.8 0.009 15.7 4.8 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_10 PF16685.3 001113396.1_39723001_1 - 0.004 17.1 3.3 0.004 17.1 3.3 2.1 2 0 0 2 2 2 1 zinc RING finger of MSL2 U-box PF04564.13 001113396.1_39723001_1 - 0.0055 16.7 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 U-box domain YojJ PF10372.7 001113396.1_39723001_1 - 0.038 13.9 1.8 6.4 6.8 0.2 2.7 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus FAM76 PF16046.3 001113396.1_39723001_1 - 0.079 12.2 7.0 0.17 11.1 7.0 1.5 1 0 0 1 1 1 0 FAM76 protein UBZ_FAAP20 PF15750.3 001113396.1_39723001_1 - 0.11 12.4 2.2 1.1 9.1 0.1 2.6 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger zf-RING_4 PF14570.4 001113396.1_39723001_1 - 0.17 11.5 5.0 1.2 8.7 5.2 2.3 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Rad50_zn_hook PF04423.12 001113396.1_39723001_1 - 0.19 11.5 2.5 1.4 8.7 0.1 3.2 3 0 0 3 3 3 0 Rad50 zinc hook motif zf-rbx1 PF12678.5 001113396.1_39723001_1 - 1.1 9.4 13.1 0.03 14.5 5.0 2.5 2 1 0 2 2 2 0 RING-H2 zinc finger domain Baculo_IE-1 PF05290.9 001113396.1_39723001_1 - 2 8.2 7.0 0.23 11.3 0.9 2.6 3 1 1 4 4 3 0 Baculovirus immediate-early protein (IE-0) zf-RING_11 PF17123.3 001113396.1_39723001_1 - 2 8.0 5.6 10 5.8 3.8 2.8 2 1 0 2 2 2 0 RING-like zinc finger zf-Di19 PF05605.10 001113396.1_39723001_1 - 3.9 7.7 9.4 8.5 6.6 0.1 3.3 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding CREPT PF16566.3 001113396.1_39723001_1 - 8.1 6.5 12.7 0.37 10.8 3.2 2.2 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour zf-RING_2 PF13639.4 001194101.1_29624001_1 - 4.8e-14 52.2 4.7 7.9e-14 51.5 4.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.3 001194101.1_29624001_1 - 1.7e-11 43.5 0.6 1.7e-11 43.5 0.6 2.5 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4_2 PF13923.4 001194101.1_29624001_1 - 1.7e-09 37.2 4.5 2.8e-09 36.5 4.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001194101.1_29624001_1 - 1.5e-08 34.2 3.5 2.4e-08 33.6 3.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PA PF02225.20 001194101.1_29624001_1 - 1.6e-08 34.4 0.0 4e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 PA domain zf-RING_5 PF14634.4 001194101.1_29624001_1 - 1.1e-07 31.5 2.8 2e-07 30.7 2.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.5 001194101.1_29624001_1 - 1.6e-06 28.1 6.5 6e-06 26.3 6.5 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.4 001194101.1_29624001_1 - 4.1e-06 26.6 3.7 4.8e-05 23.2 0.4 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 001194101.1_29624001_1 - 4.3e-06 26.4 3.3 6.9e-06 25.7 3.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 001194101.1_29624001_1 - 0.00041 20.0 4.2 0.00081 19.1 4.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.5 001194101.1_29624001_1 - 0.004 17.1 4.0 0.01 15.7 4.0 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger PHD PF00628.27 001194101.1_29624001_1 - 0.058 13.2 3.7 0.11 12.3 3.7 1.5 1 0 0 1 1 1 0 PHD-finger RINGv PF12906.5 001194101.1_29624001_1 - 0.11 12.5 3.9 0.22 11.6 3.9 1.5 1 0 0 1 1 1 0 RING-variant domain Zn_ribbon_17 PF17120.3 001194101.1_29624001_1 - 0.12 11.9 2.9 0.22 11.0 2.9 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Glucos_trans_II PF14264.4 001194101.1_29624001_1 - 0.14 11.4 0.0 0.2 10.8 0.0 1.1 1 0 0 1 1 1 0 Glucosyl transferase GtrII zf-C3H2C3 PF17122.3 001194101.1_29624001_1 - 0.4 10.6 3.8 1.2 9.1 3.8 1.8 1 1 0 1 1 1 0 Zinc-finger zf-RING_4 PF14570.4 001194101.1_29624001_1 - 0.53 9.9 5.2 1 9.0 5.2 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.9 001194101.1_29624001_1 - 0.62 10.3 3.9 1.3 9.2 3.9 1.6 1 0 0 1 1 1 0 RING-like domain FANCL_C PF11793.6 001194101.1_29624001_1 - 0.98 9.5 5.5 4.8 7.3 5.5 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain PRY PF13765.4 001257752.1_29627001_1 - 1.4e-16 59.7 0.0 3.6e-16 58.4 0.0 1.8 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 001257752.1_29627001_1 - 1.6e-14 54.0 0.1 2.6e-14 53.3 0.1 1.3 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_4 PF15227.4 001257752.1_29627001_1 - 6.1e-10 39.0 7.6 1.8e-09 37.5 7.6 1.9 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001257752.1_29627001_1 - 1.2e-08 34.5 6.8 3.3e-08 33.1 6.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001257752.1_29627001_1 - 5.2e-08 32.6 6.6 1.6e-07 31.0 6.6 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 001257752.1_29627001_1 - 1.8e-06 27.9 8.3 7e-06 26.1 8.3 2.1 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 001257752.1_29627001_1 - 4e-06 26.4 6.8 1.1e-05 25.0 6.8 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001257752.1_29627001_1 - 4.9e-05 23.3 0.9 4.9e-05 23.3 0.9 3.1 3 0 0 3 3 2 1 B-box zinc finger zf-C3HC4_3 PF13920.4 001257752.1_29627001_1 - 5e-05 22.9 5.6 5e-05 22.9 5.6 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001257752.1_29627001_1 - 0.00017 21.3 6.8 0.00017 21.3 6.8 2.1 2 0 0 2 2 1 1 zinc-RING finger domain zf-RING_6 PF14835.4 001257752.1_29627001_1 - 0.00052 19.7 5.3 0.0012 18.6 5.3 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.3 001257752.1_29627001_1 - 0.0082 16.1 3.6 0.021 14.8 3.6 1.7 1 0 0 1 1 1 1 zinc RING finger of MSL2 DUF3416 PF11896.6 001257752.1_29627001_1 - 0.0098 16.1 3.2 0.0098 16.1 3.2 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF3416) CorA PF01544.16 001257752.1_29627001_1 - 0.015 14.5 7.7 0.021 14.0 7.7 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein KxDL PF10241.7 001257752.1_29627001_1 - 0.031 14.4 10.7 0.046 13.9 1.3 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein Ribosomal_L37ae PF01780.17 001257752.1_29627001_1 - 0.042 13.8 0.2 0.11 12.4 0.2 1.7 1 0 0 1 1 1 0 Ribosomal L37ae protein family U-box PF04564.13 001257752.1_29627001_1 - 0.073 13.1 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 U-box domain AAA_13 PF13166.4 001257752.1_29627001_1 - 0.078 11.5 5.6 0.11 11.0 5.6 1.1 1 0 0 1 1 1 0 AAA domain Atg14 PF10186.7 001257752.1_29627001_1 - 0.16 10.9 7.1 0.26 10.2 7.1 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Phasin PF05597.9 001257752.1_29627001_1 - 0.16 11.9 7.8 0.27 11.2 7.8 1.3 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Fib_alpha PF08702.8 001257752.1_29627001_1 - 0.24 11.4 7.5 0.52 10.4 7.4 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Gp-FAR-1 PF05823.10 001257752.1_29627001_1 - 0.32 11.2 3.3 0.94 9.7 3.3 1.7 1 1 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) IncA PF04156.12 001257752.1_29627001_1 - 0.36 10.5 14.9 0.71 9.5 14.9 1.5 1 0 0 1 1 1 0 IncA protein DUF1664 PF07889.10 001257752.1_29627001_1 - 0.37 10.7 7.8 1.6 8.6 1.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) LXG PF04740.10 001257752.1_29627001_1 - 0.45 10.0 9.2 0.041 13.5 2.3 2.0 2 0 0 2 2 2 0 LXG domain of WXG superfamily PilJ PF13675.4 001257752.1_29627001_1 - 0.46 10.4 7.2 1.3 9.0 7.1 1.8 1 1 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term Exonuc_VII_L PF02601.13 001257752.1_29627001_1 - 0.62 9.4 8.8 0.96 8.8 8.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Prominin PF05478.9 001257752.1_29627001_1 - 0.63 7.8 2.4 0.89 7.3 2.4 1.1 1 0 0 1 1 1 0 Prominin V_ATPase_I PF01496.17 001257752.1_29627001_1 - 1.1 6.9 6.0 1.6 6.4 6.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Prok-RING_4 PF14447.4 001257752.1_29627001_1 - 1.2 8.9 12.7 0.037 13.8 5.9 2.1 2 0 0 2 2 1 0 Prokaryotic RING finger family 4 Uso1_p115_C PF04871.11 001257752.1_29627001_1 - 1.5 9.1 15.5 2.4 8.4 15.5 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Spc24 PF08286.9 001257752.1_29627001_1 - 2.3 8.3 9.6 0.61 10.2 1.1 2.2 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF16 PF01519.14 001257752.1_29627001_1 - 2.7 8.4 6.1 2.9 8.3 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF16 Laminin_II PF06009.10 001257752.1_29627001_1 - 2.8 7.8 8.1 12 5.8 2.8 2.2 1 1 1 2 2 2 0 Laminin Domain II DUF4337 PF14235.4 001257752.1_29627001_1 - 2.8 7.9 5.9 4.6 7.2 5.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) OmpH PF03938.12 001257752.1_29627001_1 - 3.3 7.6 12.2 6 6.7 12.2 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TMPIT PF07851.11 001257752.1_29627001_1 - 5.2 6.1 9.1 7.8 5.5 9.1 1.1 1 0 0 1 1 1 0 TMPIT-like protein Snapin_Pallidin PF14712.4 001257752.1_29627001_1 - 5.4 7.4 14.3 0.34 11.3 7.8 2.0 1 1 1 2 2 2 0 Snapin/Pallidin Spore_III_AB PF09548.8 001257752.1_29627001_1 - 5.8 6.9 9.7 10 6.0 9.7 1.4 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) Spc7 PF08317.9 001257752.1_29627001_1 - 6.3 5.4 15.1 11 4.7 15.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Apolipoprotein PF01442.16 001257752.1_29627001_1 - 6.3 6.5 20.6 38 4.0 10.3 1.9 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain AAA_32 PF13654.4 001257752.1_29627001_1 - 6.4 5.3 12.8 8 5.0 6.3 2.0 1 1 1 2 2 2 0 AAA domain DUF3584 PF12128.6 001257752.1_29627001_1 - 9 3.5 17.4 12 3.1 17.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Baculo_PEP_C PF04513.10 001257752.1_29627001_1 - 9.6 6.1 6.3 14 5.6 0.6 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus zf-C3HC4_4 PF15227.4 001266728.2_29626001_2 - 2e-10 40.5 7.7 2e-10 40.5 7.7 3.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001266728.2_29626001_2 - 1.9e-09 37.1 6.0 1.9e-09 37.1 6.0 2.4 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001266728.2_29626001_2 - 2.9e-08 33.5 7.9 2.9e-08 33.5 7.9 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 001266728.2_29626001_2 - 2e-07 30.6 7.7 7.2e-07 28.8 7.7 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001266728.2_29626001_2 - 2.7e-05 24.2 8.2 2.7e-05 24.2 8.2 3.0 3 0 0 3 3 1 1 Ring finger domain zf-C3HC4_3 PF13920.4 001266728.2_29626001_2 - 2.9e-05 23.7 5.8 2.9e-05 23.7 5.8 3.3 3 0 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001266728.2_29626001_2 - 0.00027 20.9 7.8 0.00027 20.9 7.8 4.8 5 1 0 5 5 4 1 B-box zinc finger zf-RING_5 PF14634.4 001266728.2_29626001_2 - 0.005 16.6 5.8 0.005 16.6 5.8 3.6 4 1 0 4 4 3 1 zinc-RING finger domain zf-RING_10 PF16685.3 001266728.2_29626001_2 - 0.0087 16.0 3.4 0.0087 16.0 3.4 2.6 3 0 0 3 3 2 1 zinc RING finger of MSL2 zf-Nse PF11789.6 001266728.2_29626001_2 - 0.044 13.5 3.7 0.12 12.1 3.7 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.4 001266728.2_29626001_2 - 0.046 13.5 3.3 0.17 11.7 3.3 1.9 1 0 0 1 1 1 0 zf-RING of BARD1-type protein CASP_C PF08172.10 001266728.2_29626001_2 - 0.059 12.6 3.5 0.093 11.9 3.5 1.3 1 0 0 1 1 1 0 CASP C terminal dCache_2 PF08269.9 001266728.2_29626001_2 - 0.073 12.1 0.5 0.1 11.6 0.5 1.1 1 0 0 1 1 1 0 Cache domain RNF220 PF15926.3 001131864.1_43524001_1 - 1.5e-49 168.7 14.8 1.9e-47 161.9 0.9 2.9 2 1 1 3 3 3 2 E3 ubiquitin-protein ligase RNF220 zf-C3HC4_2 PF13923.4 001131864.1_43524001_1 - 8.9e-14 50.9 11.1 8.9e-14 50.9 11.1 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001131864.1_43524001_1 - 0.00012 21.7 7.6 0.00012 21.7 7.6 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001131864.1_43524001_1 - 0.00034 20.4 7.8 0.00076 19.3 7.8 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.23 001131864.1_43524001_1 - 0.00041 20.0 9.8 0.0011 18.6 9.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001131864.1_43524001_1 - 0.00072 19.6 10.6 0.0025 17.9 10.6 2.0 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.4 001131864.1_43524001_1 - 0.0086 15.9 5.8 0.027 14.3 5.8 1.9 1 0 0 1 1 1 1 RING-type zinc-finger Pox_A_type_inc PF04508.10 001131864.1_43524001_1 - 0.044 13.5 0.4 0.095 12.5 0.4 1.5 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat zf-ANAPC11 PF12861.5 001131864.1_43524001_1 - 0.058 13.3 2.4 0.14 12.1 2.4 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.4 001131864.1_43524001_1 - 0.18 11.6 6.5 0.4 10.5 6.5 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.4 001131864.1_43524001_1 - 0.8 9.8 9.2 2.6 8.1 9.2 2.0 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Peptidase_M57 PF12388.6 001131864.1_43524001_2 - 0.26 10.7 0.8 0.4 10.1 0.8 1.2 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase zf-RING_2 PF13639.4 001266784.1_29623001_3 - 2.6e-13 49.9 8.2 2.6e-13 49.9 8.2 3.0 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.4 001266784.1_29623001_3 - 3.7e-08 32.9 7.5 3.7e-08 32.9 7.5 2.5 3 0 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 001266784.1_29623001_3 - 3.9e-08 32.7 3.9 3.9e-08 32.7 3.9 2.2 3 0 0 3 3 2 1 RING-like zinc finger zf-rbx1 PF12678.5 001266784.1_29623001_3 - 7.8e-08 32.4 4.4 7.8e-08 32.4 4.4 2.2 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.4 001266784.1_29623001_3 - 1.5e-06 28.0 5.4 1.5e-06 28.0 5.4 2.8 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 001266784.1_29623001_3 - 2.1e-06 27.5 7.8 8.5e-06 25.6 6.1 2.9 2 1 1 3 3 3 1 RING-type zinc-finger zinc_ribbon_9 PF14369.4 001266784.1_29623001_3 - 4.9e-06 26.5 3.6 4.9e-06 26.5 3.6 3.0 3 0 0 3 3 3 1 zinc-ribbon zf-C3HC4 PF00097.23 001266784.1_29623001_3 - 7.2e-06 25.7 6.8 7.2e-06 25.7 6.8 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001266784.1_29623001_3 - 3.3e-05 23.5 3.1 3.3e-05 23.5 3.1 2.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 001266784.1_29623001_3 - 0.002 18.0 3.2 0.002 18.0 3.2 2.3 3 1 0 3 3 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger HypA PF01155.17 001266784.1_29623001_3 - 0.0041 17.0 4.9 0.6 10.0 0.1 2.2 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Prok-RING_4 PF14447.4 001266784.1_29623001_3 - 0.0046 16.7 7.3 0.0046 16.7 7.3 2.9 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 DZR PF12773.5 001266784.1_29623001_3 - 0.016 15.0 6.2 0.31 11.0 0.2 2.9 2 1 0 2 2 2 0 Double zinc ribbon zf-Nse PF11789.6 001266784.1_29623001_3 - 0.044 13.5 4.0 0.079 12.7 4.0 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zinc-ribbons_6 PF07191.10 001266784.1_29623001_3 - 0.17 11.7 6.8 4.2 7.3 0.1 2.6 2 0 0 2 2 2 0 zinc-ribbons Rad50_zn_hook PF04423.12 001266784.1_29623001_3 - 0.4 10.4 5.9 0.47 10.2 0.2 2.9 3 0 0 3 3 3 0 Rad50 zinc hook motif Zn_ribbon_17 PF17120.3 001266784.1_29623001_3 - 0.78 9.3 11.7 0.13 11.7 4.5 2.5 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type DUF1272 PF06906.9 001266784.1_29623001_3 - 3 7.9 9.6 2.6 8.1 0.4 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1272) zinc_ribbon_4 PF13717.4 001266784.1_29623001_3 - 3.1 7.7 5.9 2 8.3 0.1 3.0 3 0 0 3 3 3 0 zinc-ribbon domain FANCL_C PF11793.6 001266784.1_29623001_3 - 3.8 7.6 7.4 67 3.6 7.5 2.9 1 1 1 2 2 2 0 FANCL C-terminal domain DUF329 PF03884.12 001266784.1_29623001_3 - 9.7 5.9 7.2 18 5.1 0.6 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF329) zf-B_box PF00643.22 001280368.1_39726001_3 - 1.4e-09 37.8 31.9 1.6e-08 34.4 4.5 4.0 3 1 0 3 3 3 2 B-box zinc finger zf-RING_UBOX PF13445.4 001280368.1_39726001_3 - 5.6e-09 35.7 3.0 5.6e-09 35.7 3.0 3.0 3 0 0 3 3 3 1 RING-type zinc-finger fn3 PF00041.19 001280368.1_39726001_3 - 3.3e-07 30.4 0.0 6.9e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain zf-C3HC4_4 PF15227.4 001280368.1_39726001_3 - 8.6e-06 25.7 4.4 8.6e-06 25.7 4.4 3.3 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001280368.1_39726001_3 - 1.7e-05 24.5 4.3 1.7e-05 24.5 4.3 4.3 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001280368.1_39726001_3 - 0.00023 20.9 2.0 0.00023 20.9 2.0 4.2 3 1 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 001280368.1_39726001_3 - 0.00029 20.5 3.6 0.00029 20.5 3.6 4.3 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) SPRY PF00622.26 001280368.1_39726001_3 - 0.00084 19.3 0.0 0.0017 18.3 0.0 1.5 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_2 PF13923.4 001280368.1_39726001_3 - 0.0021 17.7 5.8 0.0021 17.7 5.8 3.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) ATP-synt_B PF00430.16 001280368.1_39726001_3 - 0.0055 16.6 0.9 0.012 15.6 0.9 1.5 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) zf-RING_UBOX PF13445.4 001246517.1_39723001_2 - 7.7e-11 41.7 9.7 7.7e-11 41.7 9.7 2.8 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001246517.1_39723001_2 - 6.6e-08 32.2 8.8 6.6e-08 32.2 8.8 2.5 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001246517.1_39723001_2 - 3.5e-07 29.9 6.4 3.5e-07 29.9 6.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001246517.1_39723001_2 - 7.3e-07 29.1 3.6 7.3e-07 29.1 3.6 3.0 3 0 0 3 3 3 1 B-box zinc finger zf-RING_2 PF13639.4 001246517.1_39723001_2 - 1.5e-06 28.2 10.4 1.5e-06 28.2 10.4 2.5 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.4 001246517.1_39723001_2 - 1.8e-06 27.7 8.0 1.8e-06 27.7 8.0 2.7 2 1 1 3 3 3 1 zinc-RING finger domain zf-C3HC4_4 PF15227.4 001246517.1_39723001_2 - 6.4e-06 26.1 10.5 6.4e-06 26.1 10.5 2.7 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 001246517.1_39723001_2 - 0.00019 21.0 13.4 0.00019 21.0 13.4 3.5 2 2 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) RecG_N PF17190.2 001246517.1_39723001_2 - 0.061 13.9 1.9 0.59 10.8 1.7 2.6 2 0 0 2 2 2 0 RecG N-terminal helical domain ATP-synt_E_2 PF08112.9 001246517.1_39723001_2 - 0.11 12.7 3.0 0.21 11.8 0.5 2.4 2 0 0 2 2 2 0 ATP synthase epsilon subunit BCCT PF02028.15 001246517.1_39723001_2 - 0.22 9.8 2.8 0.33 9.2 2.8 1.1 1 0 0 1 1 1 0 BCCT, betaine/carnitine/choline family transporter Prok-RING_4 PF14447.4 001246517.1_39723001_2 - 0.37 10.6 18.8 0.044 13.5 11.2 3.0 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.4 001246517.1_39723001_2 - 1.5 8.5 14.3 0.04 13.5 6.7 2.3 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.4 001113359.1_29623001_1 - 1.3e-12 47.3 6.0 3.6e-11 42.8 2.4 2.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 001113359.1_29623001_1 - 1.2e-11 44.4 8.2 1.2e-11 44.4 8.2 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001113359.1_29623001_1 - 5.8e-10 38.7 7.2 1.5e-09 37.4 7.2 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001113359.1_29623001_1 - 9.3e-09 35.2 3.9 9.3e-09 35.2 3.9 3.1 3 1 0 3 3 3 1 B-box zinc finger zf-C3HC4_2 PF13923.4 001113359.1_29623001_1 - 1.6e-08 34.1 7.2 2.9e-07 30.1 8.2 2.5 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SPRY PF00622.26 001113359.1_29623001_1 - 1.3e-07 31.6 2.0 1.6e-07 31.3 0.2 2.0 2 0 0 2 2 2 1 SPRY domain zf-RING_2 PF13639.4 001113359.1_29623001_1 - 2.4e-07 30.8 7.0 2.4e-07 30.8 7.0 2.2 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.4 001113359.1_29623001_1 - 2.2e-06 27.4 5.4 2.2e-06 27.4 5.4 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 001113359.1_29623001_1 - 4.7e-06 26.2 5.2 4.7e-06 26.2 5.2 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.6 001113359.1_29623001_1 - 0.002 17.8 4.4 0.0066 16.1 4.4 1.8 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.13 001113359.1_29623001_1 - 0.0027 17.7 0.0 0.0056 16.7 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-RING_6 PF14835.4 001113359.1_29623001_1 - 0.0075 16.0 5.2 0.025 14.3 5.2 1.9 1 1 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.3 001113359.1_29623001_1 - 0.0093 16.0 4.5 0.0093 16.0 4.5 2.6 1 1 1 2 2 2 1 zinc RING finger of MSL2 ABC1 PF03109.14 001113359.1_29623001_1 - 0.093 12.8 0.2 0.23 11.5 0.2 1.6 1 0 0 1 1 1 0 ABC1 family UBZ_FAAP20 PF15750.3 001113359.1_29623001_1 - 0.095 12.5 2.6 0.91 9.4 0.1 2.8 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger Prok-RING_4 PF14447.4 001113359.1_29623001_1 - 0.12 12.1 15.8 0.036 13.8 10.3 2.7 2 1 1 3 3 2 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.4 001113359.1_29623001_1 - 0.22 11.2 5.4 1.6 8.4 5.7 2.3 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Rad50_zn_hook PF04423.12 001113359.1_29623001_1 - 0.39 10.4 0.1 0.39 10.4 0.1 3.7 4 0 0 4 4 4 0 Rad50 zinc hook motif zf-RING_11 PF17123.3 001113359.1_29623001_1 - 1.4 8.5 5.7 10 5.8 3.8 2.9 2 1 0 2 2 2 0 RING-like zinc finger zf-rbx1 PF12678.5 001113359.1_29623001_1 - 2 8.7 14.8 0.065 13.4 5.2 2.8 2 1 0 2 2 2 0 RING-H2 zinc finger domain zf-Di19 PF05605.10 001113359.1_29623001_1 - 4.6 7.5 11.5 8.5 6.6 0.1 3.3 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding RRM_3 PF08777.9 001113359.1_29623001_1 - 8 6.4 8.2 2.8 7.9 4.4 2.1 1 1 1 2 2 2 0 RNA binding motif zf-C3HC4 PF00097.23 001164330.1_29627001_3 - 2.8e-08 33.4 3.6 7.9e-08 31.9 3.6 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001164330.1_29627001_3 - 4.1e-08 33.1 5.6 1.8e-07 31.1 5.6 2.2 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 001164330.1_29627001_3 - 4.1e-05 23.2 5.9 0.00016 21.3 5.9 2.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001164330.1_29627001_3 - 0.00048 19.8 7.3 0.00048 19.8 7.3 2.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001164330.1_29627001_3 - 0.00056 19.7 4.7 0.00056 19.7 4.7 2.1 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.4 001164330.1_29627001_3 - 0.0014 18.7 6.4 0.0014 18.7 6.4 2.8 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_5 PF17121.3 001164330.1_29627001_3 - 0.045 13.5 5.3 0.14 11.9 4.5 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001164330.1_29627001_3 - 0.19 11.6 4.7 0.62 9.9 4.7 2.0 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_6 PF14835.4 001164330.1_29627001_3 - 3.7 7.4 13.6 5.1 6.9 1.6 2.6 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.4 001290250.1_22424001_1 - 1.1e-10 41.3 7.7 1.1e-10 41.3 7.7 3.3 4 0 0 4 4 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001290250.1_22424001_1 - 1.1e-09 37.9 6.0 1.1e-09 37.9 6.0 2.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001290250.1_22424001_1 - 9.3e-09 35.0 7.1 9.3e-09 35.0 7.1 2.7 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 001290250.1_22424001_1 - 8.9e-08 31.7 7.7 4.2e-07 29.6 7.7 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001290250.1_22424001_1 - 1.5e-05 25.0 8.2 1.5e-05 25.0 8.2 3.2 3 0 0 3 3 1 1 Ring finger domain zf-C3HC4_3 PF13920.4 001290250.1_22424001_1 - 1.6e-05 24.5 5.8 1.6e-05 24.5 5.8 3.5 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001290250.1_22424001_1 - 0.00015 21.7 7.8 0.00015 21.7 7.8 5.1 5 1 0 5 5 4 1 B-box zinc finger zf-RING_5 PF14634.4 001290250.1_22424001_1 - 0.0046 16.8 6.5 0.0046 16.8 6.5 3.9 3 2 1 4 4 3 1 zinc-RING finger domain zf-RING_10 PF16685.3 001290250.1_22424001_1 - 0.0046 16.9 3.4 0.0046 16.9 3.4 2.9 3 0 0 3 3 2 1 zinc RING finger of MSL2 CASP_C PF08172.10 001290250.1_22424001_1 - 0.02 14.1 3.0 0.033 13.4 3.0 1.4 1 0 0 1 1 1 0 CASP C terminal zf-Nse PF11789.6 001290250.1_22424001_1 - 0.023 14.4 3.7 0.068 12.9 3.7 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit dCache_2 PF08269.9 001290250.1_22424001_1 - 0.035 13.2 0.5 0.05 12.7 0.5 1.1 1 0 0 1 1 1 0 Cache domain IncA PF04156.12 001290250.1_22424001_1 - 0.15 11.7 10.6 0.22 11.2 10.6 1.2 1 0 0 1 1 1 0 IncA protein DUF3287 PF11690.6 001290250.1_22424001_1 - 0.2 11.3 1.6 0.43 10.2 1.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) Exonuc_VII_L PF02601.13 001290250.1_22424001_1 - 0.66 9.3 2.8 0.93 8.9 2.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit zf-RING_6 PF14835.4 001290250.1_22424001_1 - 5.1 6.9 11.1 0.095 12.5 3.3 2.2 2 0 0 2 2 1 0 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.4 001169053.1_40423001_1 - 7.9e-12 44.9 4.0 7.9e-12 44.9 4.0 2.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 001169053.1_40423001_1 - 3.2e-11 43.1 8.4 3.2e-11 43.1 8.4 2.1 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING SPRY PF00622.26 001169053.1_40423001_1 - 5.9e-11 42.4 0.3 1.3e-10 41.3 0.3 1.5 1 0 0 1 1 1 1 SPRY domain zf-C3HC4 PF00097.23 001169053.1_40423001_1 - 1.8e-09 37.2 6.8 6e-09 35.5 6.8 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001169053.1_40423001_1 - 6.5e-09 35.4 7.1 1.1e-07 31.4 7.9 2.6 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001169053.1_40423001_1 - 4.7e-08 32.9 3.8 4.7e-08 32.9 3.8 3.6 3 1 0 3 3 3 1 B-box zinc finger zf-RING_5 PF14634.4 001169053.1_40423001_1 - 7e-07 29.0 5.8 7e-07 29.0 5.8 2.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 001169053.1_40423001_1 - 1e-06 28.7 7.2 1e-06 28.7 7.2 2.4 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.4 001169053.1_40423001_1 - 3.3e-06 26.7 5.0 3.3e-06 26.7 5.0 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) PRY PF13765.4 001169053.1_40423001_1 - 1.5e-05 24.4 0.1 4.2e-05 22.9 0.1 1.9 1 0 0 1 1 1 1 SPRY-associated domain zf-Nse PF11789.6 001169053.1_40423001_1 - 0.0022 17.7 4.3 0.0057 16.3 4.3 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_10 PF16685.3 001169053.1_40423001_1 - 0.0084 16.1 2.7 0.0084 16.1 2.7 2.5 2 0 0 2 2 2 1 zinc RING finger of MSL2 Transposase_24 PF03004.12 001169053.1_40423001_1 - 0.058 13.4 0.9 0.12 12.4 0.9 1.4 1 0 0 1 1 1 0 Plant transposase (Ptta/En/Spm family) U-box PF04564.13 001169053.1_40423001_1 - 0.067 13.2 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 U-box domain UBZ_FAAP20 PF15750.3 001169053.1_40423001_1 - 0.1 12.4 1.3 2.7 7.9 0.0 2.9 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger DUF1796 PF08795.8 001169053.1_40423001_1 - 0.11 12.4 1.3 0.24 11.2 1.3 1.6 1 0 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) Fib_alpha PF08702.8 001169053.1_40423001_1 - 0.13 12.3 9.9 0.23 11.5 9.9 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family zf-UDP PF14569.4 001169053.1_40423001_1 - 0.14 12.1 3.9 0.1 12.6 1.4 2.1 2 0 0 2 2 1 0 Zinc-binding RING-finger zf-RING_6 PF14835.4 001169053.1_40423001_1 - 0.43 10.4 8.8 0.12 12.1 4.0 2.5 2 1 0 2 2 2 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.4 001169053.1_40423001_1 - 0.59 9.8 6.8 5.4 6.7 7.1 2.5 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain OmpH PF03938.12 001169053.1_40423001_1 - 0.65 9.9 11.9 1.1 9.1 11.9 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Exonuc_VII_L PF02601.13 001169053.1_40423001_1 - 1.3 8.4 4.9 1.7 8.0 4.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit CorA PF01544.16 001169053.1_40423001_1 - 1.9 7.6 5.8 3.2 6.8 5.8 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DZR PF12773.5 001169053.1_40423001_1 - 2.5 8.1 11.3 0.25 11.3 4.8 2.6 2 1 0 2 2 2 0 Double zinc ribbon Prok-RING_4 PF14447.4 001169053.1_40423001_1 - 3 7.6 17.5 0.2 11.4 9.8 2.9 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 ApoLp-III PF07464.9 001169053.1_40423001_1 - 3.2 7.7 9.1 0.64 10.0 3.7 2.0 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) zf-rbx1 PF12678.5 001169053.1_40423001_1 - 4.7 7.4 11.7 0.75 10.0 5.5 2.8 2 1 0 2 2 2 0 RING-H2 zinc finger domain zf-Di19 PF05605.10 001169053.1_40423001_1 - 8.7 6.6 9.2 10 6.3 0.2 3.8 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding NHL PF01436.19 001309047.1_22425001_2 - 8e-34 113.8 0.8 1e-05 25.2 0.1 6.4 6 0 0 6 6 6 5 NHL repeat zf-RING_UBOX PF13445.4 001309047.1_22425001_2 - 3.3e-11 42.9 6.3 3.3e-11 42.9 6.3 2.8 2 0 0 2 2 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 001309047.1_22425001_2 - 1.5e-09 37.8 8.2 1.5e-09 37.8 8.2 3.0 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.4 001309047.1_22425001_2 - 1.7e-07 31.0 7.8 1.7e-07 31.0 7.8 3.3 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4 PF00097.23 001309047.1_22425001_2 - 1.9e-07 30.7 8.6 1.9e-07 30.7 8.6 3.0 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001309047.1_22425001_2 - 3.3e-05 23.8 8.2 3.3e-05 23.8 8.2 3.3 3 1 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 001309047.1_22425001_2 - 5.3e-05 22.8 8.5 5.3e-05 22.8 8.5 3.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Baculo_IE-1 PF05290.9 001309047.1_22425001_2 - 6.8e-05 22.7 0.3 0.00019 21.3 0.3 1.7 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-RING_4 PF14570.4 001309047.1_22425001_2 - 0.0001 21.8 5.1 0.0001 21.8 5.1 2.9 3 0 0 3 3 2 1 RING/Ubox like zinc-binding domain zf-B_box PF00643.22 001309047.1_22425001_2 - 0.00026 21.0 3.4 0.00026 21.0 3.4 3.1 3 1 0 3 3 2 1 B-box zinc finger Prok-RING_4 PF14447.4 001309047.1_22425001_2 - 0.00042 20.0 9.1 0.00042 20.0 9.1 3.8 4 1 1 5 5 4 1 Prokaryotic RING finger family 4 SGL PF08450.10 001309047.1_22425001_2 - 0.00052 19.5 0.0 12 5.3 0.0 3.9 2 1 2 4 4 4 0 SMP-30/Gluconolaconase/LRE-like region zf-RING_11 PF17123.3 001309047.1_22425001_2 - 0.0064 16.0 5.6 0.019 14.6 5.6 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_10 PF16685.3 001309047.1_22425001_2 - 0.017 15.2 3.6 0.017 15.2 3.6 2.5 2 0 0 2 2 1 0 zinc RING finger of MSL2 Zn_Tnp_IS1595 PF12760.5 001309047.1_22425001_2 - 0.04 13.8 0.0 0.04 13.8 0.0 3.6 4 0 0 4 4 3 0 Transposase zinc-ribbon domain FYVE PF01363.19 001309047.1_22425001_2 - 0.78 9.8 27.8 0.65 10.0 9.0 3.1 2 1 1 3 3 2 0 FYVE zinc finger IBR PF01485.19 001309047.1_22425001_2 - 7 6.8 14.1 0.22 11.6 0.7 3.4 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain eIF_4EBP PF05456.9 001283520.1_29522001_1 - 0.38 10.6 4.2 0.52 10.1 4.2 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) zf-Di19 PF05605.10 001283520.1_29522001_2 - 2.6e-16 59.5 2.0 2.6e-16 59.5 2.0 3.6 2 1 1 3 3 2 1 Drought induced 19 protein (Di19), zinc-binding zf-RING_UBOX PF13445.4 001283520.1_29522001_2 - 1.7e-09 37.4 9.1 1.7e-09 37.4 9.1 3.4 3 1 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001283520.1_29522001_2 - 4.1e-08 32.8 11.5 4.1e-08 32.8 11.5 3.7 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001283520.1_29522001_2 - 6.7e-08 32.2 9.6 6.7e-08 32.2 9.6 4.1 3 2 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001283520.1_29522001_2 - 2.2e-07 30.5 12.8 2.2e-07 30.5 12.8 3.0 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001283520.1_29522001_2 - 4.4e-07 29.9 11.2 4.4e-07 29.9 11.2 3.6 3 1 1 4 4 4 1 Ring finger domain zf-RING_5 PF14634.4 001283520.1_29522001_2 - 8.7e-07 28.7 11.1 8.7e-07 28.7 11.1 3.6 3 1 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_4 PF15227.4 001283520.1_29522001_2 - 1.2e-06 28.5 14.3 1.2e-06 28.5 14.3 3.5 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.4 001283520.1_29522001_2 - 0.00028 20.6 3.4 0.00028 20.6 3.4 2.3 2 0 0 2 2 2 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.4 001283520.1_29522001_2 - 0.00095 18.9 10.7 0.00095 18.9 10.7 3.4 4 0 0 4 4 4 1 Prokaryotic RING finger family 4 DUF4604 PF15377.4 001283520.1_29522001_2 - 0.0017 18.7 13.5 0.0027 18.0 13.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) AP3D1 PF06375.9 001283520.1_29522001_2 - 0.0052 17.0 16.9 0.008 16.3 16.9 1.3 1 0 0 1 1 1 1 AP-3 complex subunit delta-1 U-box PF04564.13 001283520.1_29522001_2 - 0.0076 16.3 0.0 0.02 14.9 0.0 1.7 1 0 0 1 1 1 1 U-box domain SHR3_chaperone PF08229.9 001283520.1_29522001_2 - 0.71 8.7 3.4 1 8.1 3.4 1.2 1 0 0 1 1 1 0 ER membrane protein SH3 Connexin PF00029.17 001283520.1_29522001_2 - 3.3 7.3 8.4 5.1 6.7 8.4 1.3 1 0 0 1 1 1 0 Connexin SR-25 PF10500.7 001283520.1_29522001_3 - 0.017 14.6 32.6 0.023 14.2 32.6 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4604 PF15377.4 001283520.1_29522001_3 - 0.15 12.3 18.4 0.21 11.9 18.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) ubiquitin PF00240.21 001044603.2_49826001_1 - 2.4e-19 68.7 0.0 3.9e-19 68.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family IBR PF01485.19 001044603.2_49826001_1 - 1e-10 41.5 21.3 3.3e-07 30.3 1.6 5.5 5 1 0 5 5 5 2 IBR domain, a half RING-finger domain Rad60-SLD PF11976.6 001044603.2_49826001_1 - 5.9e-08 32.3 0.1 8.9e-08 31.7 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.4 001044603.2_49826001_1 - 0.021 14.8 0.0 0.049 13.6 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 001044603.2_49826001_1 - 0.076 13.4 0.0 0.15 12.5 0.0 1.6 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Ank_2 PF12796.5 001246264.2_49829001_1 - 1.7e-41 140.5 6.8 7.4e-13 48.8 0.2 4.3 3 1 2 5 5 5 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001246264.2_49829001_1 - 1.5e-39 133.2 17.3 1.6e-09 37.8 0.1 8.1 4 2 4 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.4 001246264.2_49829001_1 - 5.4e-33 109.2 3.5 0.00012 22.0 0.0 7.5 7 0 0 7 7 7 6 Ankyrin repeat Ank_4 PF13637.4 001246264.2_49829001_1 - 6.7e-33 112.5 7.5 9.7e-10 38.7 0.0 5.8 5 1 2 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.28 001246264.2_49829001_1 - 1.9e-32 110.2 15.1 4.3e-05 23.6 0.3 6.9 6 0 0 6 6 6 6 Ankyrin repeat SAM_1 PF00536.28 001246264.2_49829001_1 - 6.5e-28 96.8 0.0 3.3e-14 52.9 0.0 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 001246264.2_49829001_1 - 1e-22 79.9 0.0 6.6e-11 42.0 0.0 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) PID PF00640.21 001246264.2_49829001_1 - 4.5e-18 65.5 0.4 7.9e-18 64.7 0.4 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 001246264.2_49829001_1 - 0.0052 16.8 0.0 0.0096 15.9 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID_2 PF14719.4 001246264.2_49829001_1 - 0.081 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) Arf PF00025.19 001162553.2_39522001_2 - 1.5e-71 239.4 0.0 1.7e-71 239.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 001162553.2_39522001_2 - 4e-14 52.7 0.0 5.8e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.18 001162553.2_39522001_2 - 7.7e-14 51.5 0.4 2.9e-08 33.1 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.8 001162553.2_39522001_2 - 7.9e-14 51.4 0.0 1e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.20 001162553.2_39522001_2 - 6.2e-13 48.5 0.0 7.9e-13 48.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.10 001162553.2_39522001_2 - 2.7e-12 46.4 0.0 3.5e-12 46.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001162553.2_39522001_2 - 3.5e-08 33.4 0.0 5e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001162553.2_39522001_2 - 0.00014 21.3 0.0 0.0062 16.0 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA PF00004.27 001162553.2_39522001_2 - 0.002 18.4 0.0 0.003 17.9 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.7 001162553.2_39522001_2 - 0.012 15.2 0.0 0.022 14.4 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.4 001162553.2_39522001_2 - 0.014 15.8 0.0 0.022 15.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain cobW PF02492.17 001162553.2_39522001_2 - 0.024 14.1 0.0 2.1 7.8 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.4 001162553.2_39522001_2 - 0.055 13.4 0.0 0.11 12.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain DUF258 PF03193.14 001162553.2_39522001_2 - 0.087 12.6 0.0 8.7 6.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF258 FeoB_N PF02421.16 001162553.2_39522001_2 - 0.12 11.7 0.1 0.34 10.3 0.1 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B PTR2 PF00854.19 214347.1_49826001_1 - 6.5e-148 492.6 11.9 3.3e-137 457.4 8.6 2.3 2 0 0 2 2 2 2 POT family DUF4397 PF14344.4 214347.1_49826001_1 - 9.1e-05 23.1 0.1 0.057 14.1 0.1 2.4 1 1 1 2 2 2 2 Domain of unknown function (DUF4397) AlgF PF11182.6 214347.1_49826001_1 - 0.0045 16.6 0.5 0.021 14.5 0.1 2.0 1 1 1 2 2 2 1 Alginate O-acetyl transferase AlgF MFS_2 PF13347.4 214347.1_49826001_1 - 0.016 13.6 0.2 0.016 13.6 0.2 3.6 3 1 1 4 4 4 0 MFS/sugar transport protein DUF4131 PF13567.4 214347.1_49826001_1 - 0.065 12.7 1.1 5.4 6.5 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) DUF2207 PF09972.7 214347.1_49826001_1 - 0.079 11.6 4.3 1.5 7.4 0.2 2.5 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Ras PF00071.20 001127673.2_39525001_2 - 6.7e-56 188.2 0.0 8.6e-56 187.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001127673.2_39525001_2 - 4e-22 78.6 0.0 5.6e-22 78.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001127673.2_39525001_2 - 4.4e-09 35.9 0.0 6.9e-09 35.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001127673.2_39525001_2 - 0.0028 17.1 0.0 0.0045 16.4 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Alpha_kinase PF02816.16 001093785.2_39529001_1 - 3.5e-41 141.3 0.0 1e-40 139.8 0.0 1.8 1 0 0 1 1 1 1 Alpha-kinase family TRPM_tetra PF16519.3 001093785.2_39529001_1 - 6.5e-27 93.3 1.3 1.4e-26 92.2 1.3 1.6 1 0 0 1 1 1 1 Tetramerisation domain of TRPM zf-C4 PF00105.16 001129737.1_39523001_1 - 2e-33 114.5 12.3 4.9e-33 113.3 12.3 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001129737.1_39523001_1 - 2.5e-24 85.9 1.5 2.5e-24 85.9 1.5 1.7 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor K_channel_TID PF07941.9 001129737.1_39523001_3 - 0.12 12.7 5.8 0.2 12.0 5.8 1.3 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain C2-set_2 PF08205.10 214087.1_49826001_2 - 6.1e-21 74.2 0.0 3.4e-20 71.8 0.0 2.2 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 214087.1_49826001_2 - 2.3e-07 31.2 1.3 0.0034 17.8 0.2 3.3 2 1 1 3 3 3 2 Immunoglobulin domain V-set PF07686.15 214087.1_49826001_2 - 1e-06 28.7 0.4 2.4e-06 27.6 0.4 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.4 214087.1_49826001_2 - 2.4e-06 27.7 0.3 0.017 15.3 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 214087.1_49826001_2 - 5.5e-06 26.2 0.1 0.044 13.7 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 214087.1_49826001_2 - 6.1e-06 26.2 1.9 0.0062 16.5 0.1 3.3 2 1 1 3 3 3 2 Immunoglobulin domain LIM PF00412.20 001166315.2_49824001_3 - 8e-27 93.1 25.1 7.7e-14 51.5 7.7 2.6 2 0 0 2 2 2 2 LIM domain Homeobox PF00046.27 001166315.2_49824001_3 - 1.9e-19 69.1 2.4 3e-19 68.5 2.4 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001166315.2_49824001_3 - 7.4e-05 22.4 0.4 0.00018 21.2 0.4 1.6 1 0 0 1 1 1 1 Homeobox KN domain DUF2175 PF09943.7 001166315.2_49824001_3 - 0.0037 17.4 0.8 0.0037 17.4 0.8 2.8 2 1 1 3 3 3 1 Uncharacterized protein conserved in archaea (DUF2175) UDPGT PF00201.16 001009359.1_22426001_3 - 5.5e-231 767.5 0.0 6.8e-231 767.2 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001009359.1_22426001_3 - 5.5e-07 29.6 2.2 8.6e-07 28.9 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase family 28 C-terminal domain Lectin_C PF00059.19 001089310.1_22423001_3 - 7.5e-25 87.6 3.9 1.7e-24 86.5 3.9 1.6 1 0 0 1 1 1 1 Lectin C-type domain Sushi PF00084.18 001089310.1_22423001_3 - 1.2e-09 38.6 16.9 2.4e-05 24.8 0.6 3.3 2 1 1 3 3 3 2 Sushi repeat (SCR repeat) EGF PF00008.25 001089310.1_22423001_3 - 2.1e-06 27.8 8.7 2.1e-06 27.8 8.7 2.6 2 0 0 2 2 2 1 EGF-like domain hEGF PF12661.5 001089310.1_22423001_3 - 0.00014 22.3 7.0 0.001 19.5 7.0 2.7 1 0 0 1 1 1 1 Human growth factor-like EGF EGF_2 PF07974.11 001089310.1_22423001_3 - 0.00035 20.7 11.8 0.0017 18.6 11.8 2.3 1 0 0 1 1 1 1 EGF-like domain MHC_I_3 PF16497.3 001009425.1_39523001_2 - 5.4e-70 234.8 0.0 6.7e-70 234.5 0.0 1.1 1 0 0 1 1 1 1 MHC-I family domain DUF4381 PF14316.4 001009425.1_39523001_2 - 1.7 8.7 4.4 2.4 8.2 2.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) I-set PF07679.14 001099941.2_49825001_1 - 2.1e-37 126.9 0.0 2.5e-18 65.8 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 001099941.2_49825001_1 - 5.7e-28 97.2 0.0 9.6e-14 51.6 0.0 3.1 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.4 001099941.2_49825001_1 - 3.5e-16 59.2 0.0 1.1e-07 31.9 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001099941.2_49825001_1 - 1.7e-12 47.2 0.0 1.3e-05 25.2 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 001099941.2_49825001_1 - 4.5e-08 33.1 0.1 0.0016 18.4 0.1 3.7 2 1 0 2 2 2 2 Immunoglobulin V-set domain BiPBP_C PF06832.10 001099941.2_49825001_1 - 0.00058 19.7 0.0 0.0077 16.1 0.0 2.4 2 0 0 2 2 2 1 Penicillin-Binding Protein C-terminus Family C2-set_2 PF08205.10 001099941.2_49825001_1 - 0.011 15.6 0.0 0.2 11.6 0.0 2.7 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Receptor_2B4 PF11465.6 001099941.2_49825001_1 - 0.11 12.6 0.0 0.44 10.7 0.0 2.0 1 0 0 1 1 1 0 Natural killer cell receptor 2B4 Peptidase_C1 PF00112.21 001123104.1_49823001_2 - 5.4e-50 170.4 13.3 7.2e-50 170.0 13.3 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.13 001123104.1_49823001_2 - 0.31 9.6 0.8 0.51 8.9 0.8 1.2 1 0 0 1 1 1 0 Peptidase C1-like family Atg8 PF02991.14 001170827.1_49822001_3 - 8.5e-43 144.7 0.5 1.1e-42 144.3 0.5 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.11 001170827.1_49822001_3 - 3.4e-05 24.0 0.0 4.9e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 zf-C4 PF00105.16 001285652.1_09024001_2 - 8.6e-31 106.1 17.2 9.1e-31 106.0 15.3 2.1 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001285652.1_09024001_2 - 1e-23 83.9 4.4 1e-23 83.9 4.4 1.9 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor V-set PF07686.15 001305026.1_22422001_3 - 1.2e-14 54.2 0.0 1.5e-14 53.9 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001305026.1_22422001_3 - 6.7e-08 32.9 0.0 1.9e-07 31.5 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001305026.1_22422001_3 - 5.5e-05 23.1 0.0 0.00013 21.9 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001305026.1_22422001_3 - 0.00012 21.9 0.0 0.00028 20.7 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 001305026.1_22422001_3 - 0.032 14.4 0.2 0.48 10.7 0.2 2.1 1 1 0 1 1 1 0 Immunoglobulin domain Adeno_E3_CR1 PF02440.13 001305026.1_22422001_3 - 0.091 12.4 0.0 2.1 8.1 0.0 2.1 2 0 0 2 2 2 0 Adenovirus E3 region protein CR1 bZIP_1 PF00170.19 001123078.1_49823001_3 - 2.3e-17 62.7 15.6 3.7e-17 62.0 15.6 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 001123078.1_49823001_3 - 3.6e-07 30.0 12.9 3.6e-07 30.0 12.9 1.6 1 1 0 1 1 1 1 Basic region leucine zipper IncA PF04156.12 001123078.1_49823001_3 - 0.0026 17.5 0.9 0.0038 16.9 0.9 1.2 1 0 0 1 1 1 1 IncA protein DUF3450 PF11932.6 001123078.1_49823001_3 - 0.0096 15.1 5.1 0.014 14.5 5.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) DUF4407 PF14362.4 001123078.1_49823001_3 - 0.026 13.8 3.8 0.036 13.3 3.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fez1 PF06818.13 001123078.1_49823001_3 - 0.042 14.2 9.0 0.063 13.6 9.0 1.1 1 0 0 1 1 1 0 Fez1 Taxilin PF09728.7 001123078.1_49823001_3 - 0.1 11.7 13.0 0.14 11.2 13.0 1.1 1 0 0 1 1 1 0 Myosin-like coiled-coil protein HOOK PF05622.10 001123078.1_49823001_3 - 0.36 8.8 9.0 0.47 8.4 9.0 1.1 1 0 0 1 1 1 0 HOOK protein Nop53 PF07767.9 001123078.1_49823001_3 - 0.59 9.4 13.4 0.81 8.9 13.4 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) bZIP_Maf PF03131.15 001123078.1_49823001_3 - 0.69 10.3 8.3 1.1 9.7 8.3 1.2 1 0 0 1 1 1 0 bZIP Maf transcription factor Laminin_II PF06009.10 001123078.1_49823001_3 - 0.94 9.4 6.8 1.5 8.7 6.8 1.2 1 0 0 1 1 1 0 Laminin Domain II AAA_13 PF13166.4 001123078.1_49823001_3 - 0.95 7.9 10.7 1.2 7.6 10.7 1.0 1 0 0 1 1 1 0 AAA domain Baculo_F PF12259.6 001123078.1_49823001_3 - 1.3 7.4 3.7 1.6 7.0 3.7 1.1 1 0 0 1 1 1 0 Baculovirus F protein Mnd1 PF03962.13 001123078.1_49823001_3 - 1.5 8.5 12.1 2.9 7.6 12.1 1.4 1 0 0 1 1 1 0 Mnd1 family APG6 PF04111.10 001123078.1_49823001_3 - 1.8 7.7 10.3 2.7 7.2 10.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 ZapB PF06005.10 001123078.1_49823001_3 - 2.6 8.4 11.4 0.15 12.4 4.5 2.0 1 1 1 2 2 2 0 Cell division protein ZapB HemX PF04375.12 001123078.1_49823001_3 - 3.4 6.7 6.4 4.6 6.3 6.4 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Atg14 PF10186.7 001123078.1_49823001_3 - 6 5.7 10.6 8.2 5.3 10.6 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 XhlA PF10779.7 001123078.1_49823001_3 - 6.9 6.8 6.9 39 4.4 2.9 2.5 3 0 0 3 3 2 0 Haemolysin XhlA DUF724 PF05266.12 001123078.1_49823001_3 - 9 5.9 16.0 5.7 6.6 14.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF724) OmpH PF03938.12 001123078.1_49823001_3 - 9.3 6.1 13.9 13 5.6 13.9 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) SCF PF02404.13 001267888.1_39522001_2 - 2.7e-92 308.9 3.2 3.2e-92 308.6 3.2 1.0 1 0 0 1 1 1 1 Stem cell factor UDPGT PF00201.16 001009383.1_22426001_1 - 9e-243 806.4 0.0 1.1e-242 806.1 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001009383.1_22426001_1 - 5.2e-07 29.7 2.2 8.6e-07 28.9 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase family 28 C-terminal domain SPO11_like PF03533.12 001105313.1_49824001_2 - 1.4e-24 85.7 4.1 1.4e-24 85.7 4.1 1.7 2 0 0 2 2 2 1 SPO11 homologue TP6A_N PF04406.12 001105313.1_49824001_2 - 6.2e-24 83.6 0.4 1.5e-23 82.4 0.4 1.7 1 0 0 1 1 1 1 Type IIB DNA topoisomerase SPRR2 PF14820.4 001009459.1_39522001_1 - 0.056 13.6 56.3 0.056 13.6 50.5 2.8 1 1 1 2 2 2 0 Small proline-rich 2 Ig_2 PF13895.4 001112636.2_40422001_3 - 4.6e-09 36.4 1.0 1.9e-06 28.0 0.1 2.5 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 001112636.2_40422001_3 - 2.1e-07 30.9 0.0 5.6e-07 29.6 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001112636.2_40422001_3 - 5.2e-06 26.8 0.2 0.076 13.5 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001112636.2_40422001_3 - 0.0061 16.5 0.0 0.022 14.7 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.23 001112636.2_40422001_3 - 0.012 15.6 0.2 0.31 11.1 0.0 2.4 2 1 0 2 2 2 0 Immunoglobulin domain C2-set_2 PF08205.10 001112636.2_40422001_3 - 0.031 14.2 0.1 0.2 11.6 0.1 2.3 1 1 1 2 2 2 0 CD80-like C2-set immunoglobulin domain IL8 PF00048.18 001009191.1_39523001_3 - 5.5e-13 48.7 0.6 9.8e-13 47.9 0.6 1.4 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like FAM209 PF15206.4 001113700.1_49822001_1 - 3.1e-82 273.6 0.0 4.1e-82 273.2 0.0 1.1 1 0 0 1 1 1 1 FAM209 family Glyco_transf_29 PF00777.16 213757.1_49824001_3 - 1.4e-60 204.9 0.0 1.8e-60 204.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Alpha-amylase PF00128.22 001082242.1_37928001_2 - 2e-83 280.6 3.1 2.9e-83 280.1 3.1 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain SLC3A2_N PF16028.3 001082242.1_37928001_2 - 0.00024 20.4 0.1 0.00045 19.6 0.1 1.4 1 0 0 1 1 1 1 Solute carrier family 3 member 2 N-terminus Malt_amylase_C PF16657.3 001082242.1_37928001_2 - 0.1 12.6 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Maltogenic Amylase, C-terminal domain DUF4723 PF15851.3 001082084.1_37923001_1 - 1.3 9.1 9.4 1.9 8.6 9.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4723) Sulfotransfer_1 PF00685.25 001172826.1_09923001_3 - 2.7e-85 286.0 1.0 3.2e-85 285.7 1.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 001172826.1_09923001_3 - 1.2e-09 38.7 0.0 4e-09 37.1 0.0 1.7 1 1 0 1 1 1 1 Sulfotransferase family Ribosomal_L41 PF05162.11 001048157.1_22421001_3 - 2.2e-10 40.3 32.8 3.2e-10 39.7 32.8 1.3 1 0 0 1 1 1 1 Ribosomal protein L41 Sushi PF00084.18 214078.1_49826001_1 - 7.8e-53 176.8 58.3 2.5e-10 40.7 3.6 6.7 6 0 0 6 6 6 6 Sushi repeat (SCR repeat) Lectin_C PF00059.19 214078.1_49826001_1 - 2.1e-21 76.5 5.2 6.6e-21 74.9 5.2 1.9 1 0 0 1 1 1 1 Lectin C-type domain EGF_2 PF07974.11 214078.1_49826001_1 - 0.00062 19.9 12.9 0.007 16.6 12.9 3.0 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.25 214078.1_49826001_1 - 0.0012 18.9 16.4 0.002 18.3 9.8 5.0 3 0 0 3 3 3 1 EGF-like domain EGF_3 PF12947.5 214078.1_49826001_1 - 0.0061 16.6 6.9 0.0061 16.6 6.9 4.2 3 0 0 3 3 3 1 EGF domain DUF525 PF04379.12 214078.1_49826001_1 - 0.35 11.0 4.4 8.7 6.5 0.0 4.2 4 0 0 4 4 4 0 ApaG domain Cyt-b5 PF00173.26 001097521.2_49824001_2 - 1.2e-13 50.8 0.0 2.1e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain MaoC_dehydratas PF01575.17 001173100.1_09925001_3 - 1.5e-38 131.0 0.0 2.8e-38 130.1 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain adh_short PF00106.23 001173100.1_09925001_3 - 2.3e-38 131.5 0.4 5e-38 130.4 0.4 1.5 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001173100.1_09925001_3 - 1.5e-31 109.7 1.5 3e-31 108.7 1.5 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase SCP2 PF02036.15 001173100.1_09925001_3 - 1.6e-23 82.9 0.1 2.9e-23 82.1 0.1 1.4 1 0 0 1 1 1 1 SCP-2 sterol transfer family KR PF08659.8 001173100.1_09925001_3 - 5.1e-14 52.5 0.4 9.2e-14 51.6 0.4 1.4 1 0 0 1 1 1 1 KR domain Alkyl_sulf_C PF14864.4 001173100.1_09925001_3 - 2.4e-05 24.5 0.0 4.2e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal MaoC_dehydrat_N PF13452.4 001173100.1_09925001_3 - 2.5e-05 24.3 0.0 0.0005 20.1 0.0 2.4 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase Bim_N PF06773.9 001173100.1_09925001_3 - 0.16 11.5 0.0 0.34 10.5 0.0 1.5 1 0 0 1 1 1 0 Bim protein N-terminus Homeobox PF00046.27 001123071.1_49829001_2 - 4.7e-07 29.4 0.3 1.1e-06 28.2 0.3 1.5 1 0 0 1 1 1 1 Homeobox domain zf-C2H2_4 PF13894.4 001123071.1_49829001_2 - 0.015 16.0 0.3 0.015 16.0 0.3 9.6 9 0 0 9 9 9 0 C2H2-type zinc finger zf-C2H2_9 PF16293.3 001123071.1_49829001_2 - 0.13 12.0 5.5 0.21 11.4 0.2 3.7 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) Homeobox_KN PF05920.9 001123071.1_49829001_2 - 0.39 10.5 1.9 0.48 10.2 0.4 2.0 2 0 0 2 2 2 0 Homeobox KN domain zf-Di19 PF05605.10 001123071.1_49829001_2 - 5.6 7.2 38.6 0.14 12.3 0.1 7.1 8 1 0 8 8 8 0 Drought induced 19 protein (Di19), zinc-binding DUF737 PF05300.9 001244176.1_49824001_3 - 2.3e-44 152.0 37.1 2.7e-31 109.4 31.8 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF737) CHCH PF06747.11 001244176.1_49824001_3 - 0.0008 19.3 3.9 0.0014 18.6 3.9 1.4 1 0 0 1 1 1 1 CHCH domain ECH_2 PF16113.3 001244176.1_49824001_3 - 0.38 10.1 6.4 0.54 9.6 6.4 1.2 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase Trypsin PF00089.24 001082336.1_37923001_1 - 1.1e-69 234.5 0.1 1.4e-69 234.2 0.1 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001082336.1_37923001_1 - 2.7e-07 31.5 0.0 6.8e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001082336.1_37923001_1 - 0.0071 16.6 0.0 0.013 15.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Hormone_1 PF00103.18 001285735.1_09022001_2 - 2.4e-73 246.3 8.8 2.9e-73 246.0 8.8 1.1 1 0 0 1 1 1 1 Somatotropin hormone family ANF_receptor PF01094.26 001113288.1_49828001_3 - 5.6e-70 236.1 0.0 6.9e-70 235.8 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 001113288.1_49828001_3 - 5.6e-27 94.9 13.6 8.5e-27 94.3 13.6 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 001113288.1_49828001_3 - 9e-14 51.1 14.0 2e-13 49.9 14.0 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001113288.1_49828001_3 - 4.6e-06 26.4 0.0 1.1e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Periplasmic binding protein zf-H2C2_5 PF13909.4 001113288.1_49828001_3 - 0.21 11.3 2.4 0.5 10.0 0.2 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Pro_isomerase PF00160.19 001308578.1_39522001_2 - 1.3e-46 158.7 0.2 1.5e-46 158.4 0.2 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD APOC4 PF15119.4 001174132.2_49821001_3 - 1.4e-50 169.3 0.3 2e-50 168.9 0.3 1.2 1 0 0 1 1 1 1 Apolipoprotein C4 Protamine_P2 PF00841.17 214252.1_49821001_2 - 1.4e-33 115.1 50.5 1.9e-33 114.7 50.5 1.2 1 0 0 1 1 1 1 Sperm histone P2 Serpin PF00079.18 001081994.1_37923001_2 - 5.7e-118 394.3 0.3 6.6e-118 394.1 0.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Protamine_P1 PF00260.18 214253.1_49821001_1 - 1.2e-12 47.6 65.7 1.6e-12 47.2 65.7 1.2 1 0 0 1 1 1 1 Protamine P1 TPD52 PF04201.13 001244387.1_49825001_2 - 2.4e-75 251.4 5.2 3.5e-75 250.9 5.2 1.2 1 0 0 1 1 1 1 Tumour protein D52 family IncA PF04156.12 001244387.1_49825001_2 - 0.047 13.3 4.3 0.075 12.7 4.3 1.3 1 0 0 1 1 1 0 IncA protein Cnn_1N PF07989.9 001244387.1_49825001_2 - 0.055 13.5 2.8 0.13 12.2 2.8 1.6 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 Apolipoprotein PF01442.16 001244387.1_49825001_2 - 0.14 11.9 5.6 0.22 11.3 5.6 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain WEMBL PF05701.9 001244387.1_49825001_2 - 0.16 10.5 8.1 0.22 10.0 8.1 1.0 1 0 0 1 1 1 0 Weak chloroplast movement under blue light HsbA PF12296.6 001244387.1_49825001_2 - 0.29 11.4 3.6 0.75 10.1 0.1 2.4 2 1 0 2 2 2 0 Hydrophobic surface binding protein A RNA_pol_A_CTD PF03118.13 001244387.1_49825001_2 - 0.3 10.7 3.8 0.16 11.6 1.4 1.7 2 0 0 2 2 2 0 Bacterial RNA polymerase, alpha chain C terminal domain Occludin_ELL PF07303.11 001244387.1_49825001_2 - 0.48 11.0 2.7 2 9.1 0.2 2.2 1 1 1 2 2 2 0 Occludin homology domain AAA_13 PF13166.4 001244387.1_49825001_2 - 0.64 8.5 8.0 1.5 7.2 1.3 2.0 1 1 1 2 2 2 0 AAA domain Uds1 PF15456.4 001244387.1_49825001_2 - 0.7 9.9 6.5 1.1 9.2 6.5 1.3 1 0 0 1 1 1 0 Up-regulated During Septation TBPIP PF07106.11 001244387.1_49825001_2 - 3.2 7.3 9.3 5.9 6.5 6.3 2.0 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Mnd1 PF03962.13 001244387.1_49825001_2 - 5.1 6.8 7.7 8.3 6.1 7.7 1.3 1 0 0 1 1 1 0 Mnd1 family OmpH PF03938.12 001244387.1_49825001_2 - 6.9 6.5 8.2 9.9 6.0 7.6 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Carn_acyltransf PF00755.18 001009259.1_39526001_3 - 1.4e-192 641.3 0.0 1.6e-192 641.1 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase CPT_N PF16484.3 001009259.1_39526001_3 - 5.5e-28 96.6 0.1 1.2e-27 95.5 0.1 1.6 1 0 0 1 1 1 1 Carnitine O-palmitoyltransferase N-terminus DUF3128 PF11326.6 001009259.1_39526001_3 - 0.021 15.0 0.1 0.098 12.9 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3128) Myc_N PF01056.16 001319575.1_37923001_1 - 1.3e-116 390.0 6.3 2e-116 389.3 6.3 1.3 1 0 0 1 1 1 1 Myc amino-terminal region Myc-LZ PF02344.13 001319575.1_37923001_1 - 1e-16 60.6 12.9 1e-16 60.6 12.9 2.0 2 0 0 2 2 2 1 Myc leucine zipper domain HLH PF00010.24 001319575.1_37923001_1 - 2.6e-15 56.0 7.6 5.1e-14 51.8 1.6 3.0 3 0 0 3 3 3 2 Helix-loop-helix DNA-binding domain TPR_1 PF00515.26 001128485.1_49823001_1 - 1.1e-17 62.9 0.8 3.4e-07 29.7 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.15 001128485.1_49823001_1 - 1.1e-13 49.9 4.4 1.8e-05 24.4 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.4 001128485.1_49823001_1 - 3.2e-10 39.8 6.8 8.8e-05 22.9 0.5 3.9 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.4 001128485.1_49823001_1 - 1.9e-08 34.5 0.3 5.6e-05 23.4 0.6 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.4 001128485.1_49823001_1 - 1.4e-07 31.9 7.2 0.00046 20.7 0.8 3.2 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_9 PF13371.4 001128485.1_49823001_1 - 2.6e-07 30.6 6.3 2e-06 27.8 0.7 2.6 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.4 001128485.1_49823001_1 - 1.7e-06 27.6 0.1 0.0026 17.7 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.4 001128485.1_49823001_1 - 1.7e-06 28.0 0.6 0.007 16.5 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.4 001128485.1_49823001_1 - 7.4e-06 25.4 0.3 0.003 17.1 0.2 2.6 2 0 0 2 2 2 1 TPR repeat TPR_6 PF13174.4 001128485.1_49823001_1 - 1.1e-05 25.6 0.9 0.083 13.4 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.4 001128485.1_49823001_1 - 8.2e-05 22.2 0.1 5.4 7.2 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.4 001128485.1_49823001_1 - 0.00029 20.9 0.3 0.085 13.2 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 001128485.1_49823001_1 - 0.00067 19.5 0.2 0.015 15.3 0.1 2.5 1 1 1 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.5 001128485.1_49823001_1 - 0.015 15.3 0.1 0.025 14.6 0.1 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 PknG_TPR PF16918.3 001128485.1_49823001_1 - 0.017 13.8 0.1 2.8 6.4 0.0 2.1 2 0 0 2 2 2 0 Protein kinase G tetratricopeptide repeat BTAD PF03704.15 001128485.1_49823001_1 - 0.018 15.4 5.9 2.2 8.6 0.4 3.1 2 1 1 3 3 3 0 Bacterial transcriptional activator domain TPR_4 PF07721.12 001128485.1_49823001_1 - 0.14 12.8 11.8 5.4 7.8 0.5 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_15 PF13429.4 001128485.1_49823001_1 - 0.3 10.1 1.8 2.4 7.2 0.4 2.5 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.4 001128485.1_49823001_1 - 2.2 8.1 5.4 8.4 6.3 0.1 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat Lipoxygenase PF00305.17 001146148.1_37926001_3 - 2.9e-57 194.4 0.0 9.4e-56 189.4 0.0 2.6 1 1 0 1 1 1 1 Lipoxygenase PLAT PF01477.21 001146148.1_37926001_3 - 1.9e-19 70.3 0.0 3.1e-19 69.5 0.0 1.3 1 0 0 1 1 1 1 PLAT/LH2 domain 2-oxoacid_dh PF00198.21 213994.1_49826001_3 - 5.3e-80 268.1 0.1 6.8e-80 267.7 0.1 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.20 213994.1_49826001_3 - 2e-31 107.5 1.2 7e-15 54.5 0.1 2.3 2 0 0 2 2 2 2 Biotin-requiring enzyme E3_binding PF02817.15 213994.1_49826001_3 - 1.4e-15 57.1 2.0 1.9e-15 56.8 0.4 2.1 1 1 1 2 2 2 1 e3 binding domain Biotin_lipoyl_2 PF13533.4 213994.1_49826001_3 - 2.3e-05 24.0 0.0 0.018 14.8 0.0 2.5 2 0 0 2 2 2 2 Biotin-lipoyl like 7tm_1 PF00001.19 001257225.1_49825001_3 - 5.5e-32 110.9 13.7 8.1e-32 110.4 13.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001257225.1_49825001_3 - 2e-05 24.3 12.9 8.8e-05 22.2 12.9 1.9 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001257225.1_49825001_3 - 0.071 12.3 7.0 0.12 11.6 7.0 1.4 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx Corona_NSP4_C PF16348.3 001257225.1_49825001_3 - 0.091 13.5 0.0 0.18 12.5 0.0 1.4 1 0 0 1 1 1 0 Coronavirus nonstructural protein 4 C-terminus Bromodomain PF00439.23 001123085.1_49829001_1 - 8.8e-41 137.7 1.4 2.2e-20 72.4 0.1 2.5 2 0 0 2 2 2 2 Bromodomain BET PF17035.3 001123085.1_49829001_1 - 6.1e-28 96.7 0.1 6.1e-28 96.7 0.1 2.0 2 0 0 2 2 2 1 Bromodomain extra-terminal - transcription regulation AF-4 PF05110.11 001123085.1_49829001_1 - 9.9e-06 23.8 50.3 0.00032 18.9 22.4 2.2 2 0 0 2 2 2 2 AF-4 proto-oncoprotein DDHD PF02862.15 001123085.1_49829001_1 - 0.013 15.6 8.4 0.12 12.3 2.2 2.4 2 0 0 2 2 2 0 DDHD domain DUF4667 PF15700.3 001123085.1_49829001_1 - 0.1 12.5 20.0 0.048 13.6 0.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) Sigma70_ner PF04546.11 001123085.1_49829001_1 - 0.37 10.5 17.6 0.013 15.2 10.9 1.8 2 0 0 2 2 2 0 Sigma-70, non-essential region RRN3 PF05327.9 001123085.1_49829001_1 - 1.4 7.2 6.5 2.7 6.3 6.5 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Utp14 PF04615.11 001123085.1_49829001_1 - 3 6.3 32.7 4.3 5.7 32.7 1.1 1 0 0 1 1 1 0 Utp14 protein CENP-B_dimeris PF09026.8 001123085.1_49829001_1 - 9.9 6.5 14.0 29 5.0 14.0 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain pKID PF02173.15 001285604.1_09023001_2 - 1e-19 69.5 1.1 2.2e-19 68.5 1.1 1.6 1 0 0 1 1 1 1 pKID domain bZIP_1 PF00170.19 001285604.1_09023001_2 - 1e-19 70.2 8.7 2.1e-19 69.2 8.7 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 001285604.1_09023001_2 - 8.3e-07 28.9 9.7 1.5e-06 28.0 9.7 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 001285604.1_09023001_2 - 0.12 12.8 4.8 0.23 11.9 4.8 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor UDPGT PF00201.16 001173115.1_09924001_2 - 4.1e-255 847.1 0.1 5.2e-255 846.8 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001173115.1_09924001_2 - 1.4e-07 31.5 0.0 2.4e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Hormone_1 PF00103.18 001042739.1_29622001_3 - 3.7e-51 173.8 0.3 4.5e-51 173.5 0.3 1.1 1 0 0 1 1 1 1 Somatotropin hormone family SPRR2 PF14820.4 001009773.1_39522001_3 - 8.8e-24 83.5 80.9 8.8e-24 83.5 80.9 1.8 2 0 0 2 2 2 1 Small proline-rich 2 Ig_2 PF13895.4 001123004.1_39523001_1 - 9.2e-22 77.1 0.8 5.7e-13 48.9 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001123004.1_39523001_1 - 6.9e-16 58.5 1.4 3.8e-08 33.7 0.5 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_4 PF16680.3 001123004.1_39523001_1 - 4.6e-08 33.2 0.9 0.00044 20.4 0.1 2.4 2 0 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain ig PF00047.23 001123004.1_39523001_1 - 7.4e-08 32.3 4.2 0.0015 18.5 0.8 3.1 2 2 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 001123004.1_39523001_1 - 1.2e-07 31.7 3.8 0.0081 16.2 0.1 4.0 2 2 2 4 4 4 3 Immunoglobulin V-set domain Ig_5 PF16681.3 001123004.1_39523001_1 - 9.6e-07 29.0 0.8 0.002 18.4 0.0 2.3 2 0 0 2 2 2 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain I-set PF07679.14 001123004.1_39523001_1 - 2.4e-06 27.4 2.5 0.056 13.4 0.5 3.1 2 2 0 2 2 2 2 Immunoglobulin I-set domain C2-set PF05790.13 001123004.1_39523001_1 - 0.058 13.4 0.0 0.18 11.9 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin C2-set domain Tad PF13400.4 001123004.1_39523001_1 - 0.072 13.3 0.8 0.13 12.4 0.1 1.7 2 0 0 2 2 2 0 Putative Flp pilus-assembly TadE/G-like TadE PF07811.10 001123004.1_39523001_1 - 0.29 11.3 3.1 0.65 10.2 3.1 1.5 1 0 0 1 1 1 0 TadE-like protein Hormone_1 PF00103.18 213926.1_49822001_1 - 8.9e-82 273.9 0.5 1e-81 273.6 0.5 1.0 1 0 0 1 1 1 1 Somatotropin hormone family KIAA1430 PF13879.4 213926.1_49822001_1 - 0.061 14.0 0.2 0.97 10.1 0.0 2.1 2 0 0 2 2 2 0 KIAA1430 homologue Jagunal PF07086.10 001280713.1_39522001_1 - 0.14 12.1 0.3 0.21 11.6 0.3 1.1 1 0 0 1 1 1 0 Jagunal, ER re-organisation during oogenesis Cystatin PF00031.19 001280713.1_39522001_2 - 5.9e-32 109.7 0.0 7.4e-32 109.4 0.0 1.1 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.3 001280713.1_39522001_2 - 2e-08 34.4 0.0 2.8e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor C1q PF00386.19 001123092.1_49827001_2 - 3.7e-23 82.0 0.6 5.2e-23 81.5 0.6 1.2 1 0 0 1 1 1 1 C1q domain Ammonium_transp PF00909.19 214378.1_49823001_3 - 1.1e-55 188.9 23.7 1.4e-55 188.5 23.7 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family AzlD PF05437.10 214378.1_49823001_3 - 0.021 14.9 2.3 0.021 14.9 2.3 2.4 2 0 0 2 2 2 0 Branched-chain amino acid transport protein (AzlD) Hormone_1 PF00103.18 001112819.1_39522001_2 - 7.4e-83 277.4 3.6 8.9e-83 277.1 3.6 1.1 1 0 0 1 1 1 1 Somatotropin hormone family Hormone_1 PF00103.18 001285622.1_09022001_2 - 1.6e-77 260.0 5.0 1.9e-77 259.7 5.0 1.1 1 0 0 1 1 1 1 Somatotropin hormone family Totivirus_coat PF05518.9 001199718.1_49825001_2 - 1.9 6.3 6.2 2.9 5.7 6.2 1.2 1 0 0 1 1 1 0 Totivirus coat protein SIX1_SD PF16878.3 001199718.1_49825001_3 - 2e-48 163.4 0.1 3.5e-48 162.6 0.1 1.4 1 0 0 1 1 1 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeobox PF00046.27 001199718.1_49825001_3 - 6e-14 51.5 1.3 1.4e-13 50.3 0.2 2.2 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.9 001199718.1_49825001_3 - 1.4e-12 47.2 0.6 3.6e-12 45.8 0.6 1.7 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.6 001199718.1_49825001_3 - 0.017 14.4 0.1 0.044 13.1 0.1 1.6 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez HTH_3 PF01381.20 001199718.1_49825001_3 - 0.024 14.5 0.0 0.089 12.7 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix bZIP_1 PF00170.19 001123102.1_49824001_2 - 2.4e-13 49.8 11.7 4.3e-13 49.0 11.7 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 001123102.1_49824001_2 - 3.4e-09 36.5 10.2 8e-09 35.3 10.2 1.6 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 001123102.1_49824001_2 - 3.4e-05 24.1 9.7 5.6e-05 23.4 9.7 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor ZapB PF06005.10 001123102.1_49824001_2 - 0.005 17.1 3.4 0.013 15.8 3.4 1.6 1 0 0 1 1 1 1 Cell division protein ZapB OppC_N PF12911.5 001123102.1_49824001_2 - 0.086 12.7 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C HAUS-augmin3 PF14932.4 001123102.1_49824001_2 - 0.26 10.6 5.6 0.38 10.1 5.6 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 IncA PF04156.12 001123102.1_49824001_2 - 0.63 9.7 9.9 0.26 10.9 7.4 1.5 1 1 0 1 1 1 0 IncA protein DUF724 PF05266.12 001123102.1_49824001_2 - 1.2 8.8 5.4 1.9 8.2 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) ADIP PF11559.6 001123102.1_49824001_2 - 1.2 9.1 13.9 1.7 8.6 13.9 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding TNF PF00229.16 001171119.1_37923001_3 - 3.6e-33 114.1 0.0 4.8e-33 113.7 0.0 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family V-set PF07686.15 001009841.1_22424001_2 - 8.4e-08 32.2 0.0 2.6e-07 30.6 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin V-set domain C2-set PF05790.13 001009841.1_22424001_2 - 3.1e-05 23.9 1.6 6.7e-05 22.9 1.6 1.6 1 0 0 1 1 1 1 Immunoglobulin C2-set domain Ig_3 PF13927.4 001009841.1_22424001_2 - 0.0021 18.5 0.7 2.3 8.7 0.0 2.9 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001009841.1_22424001_2 - 0.0043 17.0 0.7 0.039 13.9 0.1 2.7 1 1 1 2 2 2 1 Immunoglobulin I-set domain Cadherin_C_2 PF16492.3 001009841.1_22424001_2 - 0.08 13.6 0.0 0.25 12.0 0.0 1.9 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal PspB PF06667.10 001009841.1_22424001_2 - 0.12 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Phage shock protein B YhzD PF14120.4 001009841.1_22424001_2 - 0.16 12.0 1.0 0.19 11.7 0.0 1.6 2 0 0 2 2 2 0 YhzD-like protein FAM176 PF14851.4 001009841.1_22424001_2 - 0.2 11.2 0.1 0.38 10.3 0.1 1.3 1 0 0 1 1 1 0 FAM176 family TACC PF05010.12 001082146.1_37925001_2 - 9.2e-81 270.3 27.8 1.2e-80 270.0 27.8 1.1 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC) NAGLU PF05089.10 001082146.1_37925001_2 - 0.15 10.9 0.2 0.2 10.4 0.2 1.1 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain DUF4776 PF16003.3 001082146.1_37925001_2 - 0.47 9.3 13.5 0.67 8.7 13.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) V_ATPase_I PF01496.17 001082146.1_37925001_2 - 2.5 5.8 17.0 4.4 4.9 17.0 1.3 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family HMMR_N PF15905.3 001082146.1_37925001_2 - 2.5 7.3 27.6 19 4.4 27.7 1.9 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Laminin_II PF06009.10 001082146.1_37925001_2 - 4.9 7.0 12.0 2 8.3 4.3 2.4 1 1 1 2 2 2 0 Laminin Domain II ABC2_membrane PF01061.22 001078657.1_39525001_1 - 4.5e-40 137.2 20.1 4.5e-40 137.2 20.1 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.25 001078657.1_39525001_1 - 1.1e-22 80.9 0.0 1.8e-22 80.2 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.17 001078657.1_39525001_1 - 9e-06 25.1 0.4 0.082 12.2 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.4 001078657.1_39525001_1 - 5.5e-05 23.0 6.1 0.058 13.1 0.2 2.5 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.4 001078657.1_39525001_1 - 0.0031 17.9 0.3 0.0031 17.9 0.3 2.1 3 0 0 3 3 3 1 AAA domain DUF258 PF03193.14 001078657.1_39525001_1 - 0.015 15.0 0.0 0.047 13.5 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_29 PF13555.4 001078657.1_39525001_1 - 0.13 11.9 0.1 0.29 10.8 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF1774 PF08611.8 001078657.1_39525001_1 - 0.73 10.1 6.7 1.8 8.8 6.7 1.6 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF1774) ABC2_membrane_3 PF12698.5 001078657.1_39525001_1 - 1.5 7.7 31.7 0.7 8.8 26.4 2.5 2 1 1 3 3 3 0 ABC-2 family transporter protein SpecificRecomb PF10136.7 001078657.1_39525001_1 - 1.8 6.6 5.9 2.9 6.0 5.9 1.2 1 0 0 1 1 1 0 Site-specific recombinase DUF2070 PF09843.7 001078657.1_39525001_1 - 5.2 5.1 15.5 8.4 4.4 15.5 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Cystatin PF00031.19 001184972.1_22422001_1 - 4.2e-30 103.7 0.0 5.7e-30 103.3 0.0 1.2 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.3 001184972.1_22422001_1 - 3e-07 30.6 0.0 5.1e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor ADAM_CR PF08516.10 001164866.1_37925001_1 - 9.4e-27 93.6 9.9 9.4e-27 93.6 9.9 4.1 3 2 0 3 3 3 1 ADAM cysteine-rich Disintegrin PF00200.21 001164866.1_37925001_1 - 4.4e-16 59.3 26.9 4.4e-16 59.3 26.9 4.7 4 1 0 4 4 4 1 Disintegrin Pep_M12B_propep PF01562.17 001164866.1_37925001_1 - 4.2e-14 52.8 0.0 8.9e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Dickkopf_N PF04706.10 001082737.2_37923001_1 - 2e-18 66.5 34.1 3.4e-17 62.5 16.7 3.0 2 1 1 3 3 3 2 Dickkopf N-terminal cysteine-rich region COesterase PF00135.26 001173109.1_09925001_3 - 5.9e-168 559.8 0.0 6.8e-168 559.6 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 001173109.1_09925001_3 - 4.7e-10 39.5 1.0 3e-09 36.9 0.3 2.7 2 1 1 3 3 3 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 001173109.1_09925001_3 - 0.0017 17.7 0.0 0.0029 17.0 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.7 001173109.1_09925001_3 - 0.037 12.7 0.1 0.16 10.7 0.1 1.8 1 1 0 1 1 1 0 Steryl acetyl hydrolase Esterase PF00756.18 001173109.1_09925001_3 - 0.071 12.6 0.3 0.6 9.6 0.3 2.0 1 1 0 1 1 1 0 Putative esterase WAP PF00095.19 001172842.1_09921001_2 - 2.8e-08 33.9 19.6 3.9e-08 33.4 19.6 1.2 1 0 0 1 1 1 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Stk19 PF10494.7 001128450.1_49823001_1 - 2.9e-37 128.6 0.0 4.2e-37 128.0 0.0 1.2 1 0 0 1 1 1 1 Serine-threonine protein kinase 19 Pkinase PF00069.23 001285641.1_09025001_1 - 2.7e-69 233.4 0.0 4.1e-69 232.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001285641.1_09025001_1 - 4.8e-36 124.2 0.0 6.2e-36 123.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.22 001285641.1_09025001_1 - 2.7e-10 40.6 2.8 6.1e-10 39.5 2.8 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 001285641.1_09025001_1 - 5.6e-07 29.0 0.0 1.3e-06 27.8 0.0 1.6 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.4 001285641.1_09025001_1 - 0.044 13.3 0.1 8.2 5.8 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 E1-E2_ATPase PF00122.18 001173048.1_09927001_1 - 7.9e-58 195.2 1.5 7.9e-58 195.2 1.5 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 001173048.1_09927001_1 - 2.7e-25 89.0 0.8 5.4e-25 88.0 0.1 1.9 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 001173048.1_09927001_1 - 1.6e-23 82.5 0.0 2.7e-23 81.7 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 001173048.1_09927001_1 - 6.1e-19 69.0 0.1 1e-09 38.8 0.0 2.9 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 001173048.1_09927001_1 - 2.7e-18 65.2 0.0 5.1e-18 64.4 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 001173048.1_09927001_1 - 9.1e-06 25.5 1.1 0.00088 19.0 0.5 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase MHC_II_alpha PF00993.18 001185143.1_49824001_3 - 1.4e-31 107.9 0.0 2.1e-31 107.3 0.0 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set PF07654.13 001185143.1_49824001_3 - 2.2e-24 85.6 0.0 4.1e-24 84.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain C1-set_C PF16196.3 001185143.1_49824001_3 - 1.5e-22 78.6 0.1 3e-22 77.6 0.1 1.5 1 0 0 1 1 1 1 C1-set C-terminal domain Ig_3 PF13927.4 001185143.1_49824001_3 - 7.5e-05 23.1 0.0 0.00017 22.0 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 001185143.1_49824001_3 - 0.0038 17.1 0.0 0.013 15.5 0.0 1.8 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Marek_A PF02124.13 001185143.1_49824001_3 - 0.032 13.9 0.0 0.051 13.3 0.0 1.2 1 0 0 1 1 1 0 Marek's disease glycoprotein A MFS_1 PF07690.14 001082630.1_37923001_3 - 4.9e-10 38.7 21.2 2.1e-09 36.6 21.5 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily ATP-gua_Ptrans PF00217.17 001044551.2_49823001_3 - 2.5e-93 312.0 0.0 3.1e-93 311.8 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.13 001044551.2_49823001_3 - 9.7e-33 112.3 0.0 1.6e-32 111.6 0.0 1.3 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain Carn_acyltransf PF00755.18 001009414.1_39525001_3 - 5.1e-193 642.7 0.0 6.1e-193 642.5 0.0 1.1 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase CPT_N PF16484.3 001009414.1_39525001_3 - 8.2e-28 96.0 0.1 2.2e-27 94.7 0.1 1.8 1 0 0 1 1 1 1 Carnitine O-palmitoyltransferase N-terminus TCTP PF00838.15 001280680.1_39522001_1 - 1.2e-83 279.3 0.7 1.4e-83 279.0 0.7 1.1 1 0 0 1 1 1 1 Translationally controlled tumour protein VWA PF00092.26 001101815.1_49826001_1 - 2.9e-35 122.0 0.8 4.2e-35 121.4 0.8 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Trypsin PF00089.24 001101815.1_49826001_1 - 1.9e-31 109.5 0.1 7.8e-31 107.5 0.1 1.8 1 1 0 1 1 1 1 Trypsin Sushi PF00084.18 001101815.1_49826001_1 - 2.2e-22 79.3 11.0 2.4e-08 34.3 0.3 3.5 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) VWA_2 PF13519.4 001101815.1_49826001_1 - 1.8e-09 38.1 0.2 3.4e-09 37.2 0.2 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain HRM PF02793.20 001101815.1_49826001_1 - 0.00012 22.2 8.9 0.34 11.1 0.3 3.6 3 0 0 3 3 3 2 Hormone receptor domain DUF1986 PF09342.9 001101815.1_49826001_1 - 0.0008 19.6 0.1 0.0019 18.5 0.1 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 001101815.1_49826001_1 - 0.0067 17.2 0.0 0.013 16.2 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain CBM_14 PF01607.22 001101815.1_49826001_1 - 0.93 9.6 4.3 24 5.1 0.7 2.7 2 0 0 2 2 2 0 Chitin binding Peritrophin-A domain ABC_membrane PF00664.21 001082159.1_37929001_3 - 8.9e-164 543.6 28.6 5.3e-88 295.1 9.0 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 001082159.1_37929001_3 - 1.7e-74 248.7 0.3 2.2e-36 125.2 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 001082159.1_37929001_3 - 9.3e-17 61.1 0.2 8e-07 28.6 0.0 3.8 2 2 2 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 001082159.1_37929001_3 - 5e-11 43.1 0.6 0.00024 21.4 0.1 2.8 2 1 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.7 001082159.1_37929001_3 - 4.4e-09 35.5 0.9 0.00072 18.3 0.1 2.7 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_22 PF13401.4 001082159.1_37929001_3 - 3.3e-08 33.8 0.3 0.018 15.2 0.0 3.0 2 2 0 2 2 2 2 AAA domain AAA PF00004.27 001082159.1_37929001_3 - 8.7e-08 32.5 1.9 0.1 12.9 0.1 4.4 2 2 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) DUF258 PF03193.14 001082159.1_37929001_3 - 2.7e-07 30.5 0.1 0.031 14.0 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_5 PF07728.12 001082159.1_37929001_3 - 3.1e-07 30.3 0.1 0.074 12.9 0.0 3.7 4 0 0 4 4 4 2 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.10 001082159.1_37929001_3 - 7.1e-07 28.6 0.2 0.00039 19.6 0.0 3.1 3 0 0 3 3 3 1 Zeta toxin AAA_29 PF13555.4 001082159.1_37929001_3 - 2.5e-06 27.0 0.4 0.086 12.4 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain G-alpha PF00503.18 001082159.1_37929001_3 - 2.7e-06 26.7 0.0 0.013 14.5 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit Rad17 PF03215.13 001082159.1_37929001_3 - 5.9e-06 25.3 0.1 0.0061 15.4 0.0 2.2 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_14 PF13173.4 001082159.1_37929001_3 - 1.5e-05 24.9 0.1 0.1 12.5 0.0 3.7 3 1 0 4 4 3 1 AAA domain AAA_30 PF13604.4 001082159.1_37929001_3 - 3.6e-05 23.4 2.1 0.16 11.5 0.2 3.1 2 1 0 2 2 2 2 AAA domain AAA_15 PF13175.4 001082159.1_37929001_3 - 9.9e-05 22.0 0.0 0.13 11.7 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain APS_kinase PF01583.18 001082159.1_37929001_3 - 0.00017 21.4 0.2 0.43 10.3 0.0 2.7 2 0 0 2 2 2 2 Adenylylsulphate kinase RNA_helicase PF00910.20 001082159.1_37929001_3 - 0.00089 19.5 0.0 2.3 8.5 0.0 3.1 3 0 0 3 3 2 1 RNA helicase IstB_IS21 PF01695.15 001082159.1_37929001_3 - 0.0015 18.2 0.6 4.8 6.8 0.0 3.9 4 0 0 4 4 4 0 IstB-like ATP binding protein PRK PF00485.16 001082159.1_37929001_3 - 0.0016 18.1 0.0 2.2 7.8 0.0 2.4 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family ATP-synt_ab PF00006.23 001082159.1_37929001_3 - 0.0017 17.9 0.4 1.9 8.0 0.0 2.8 2 1 1 3 3 3 1 ATP synthase alpha/beta family, nucleotide-binding domain SbcCD_C PF13558.4 001082159.1_37929001_3 - 0.0026 17.8 2.0 3.5 7.8 0.2 3.9 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit DUF87 PF01935.15 001082159.1_37929001_3 - 0.0029 17.5 0.4 3.6 7.4 0.1 2.9 3 0 0 3 3 3 1 Domain of unknown function DUF87 AAA_21 PF13304.4 001082159.1_37929001_3 - 0.0035 17.1 0.0 1.5 8.4 0.0 3.4 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.4 001082159.1_37929001_3 - 0.0035 17.4 0.0 2.5 8.1 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.4 001082159.1_37929001_3 - 0.0036 16.9 0.0 1.6 8.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.11 001082159.1_37929001_3 - 0.0073 15.4 0.1 0.77 8.7 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_18 PF13238.4 001082159.1_37929001_3 - 0.0082 16.5 0.0 2.6 8.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.4 001082159.1_37929001_3 - 0.0088 16.4 0.1 5.3 7.4 0.0 2.9 3 0 0 3 3 2 0 AAA domain NTPase_1 PF03266.13 001082159.1_37929001_3 - 0.015 15.1 0.2 1.7 8.4 0.1 2.7 2 0 0 2 2 2 0 NTPase AAA_25 PF13481.4 001082159.1_37929001_3 - 0.019 14.4 0.0 3.1 7.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.4 001082159.1_37929001_3 - 0.021 14.9 0.1 19 5.3 0.0 3.2 2 1 1 3 3 3 0 AAA domain NACHT PF05729.10 001082159.1_37929001_3 - 0.022 14.5 0.1 8.2 6.2 0.0 2.4 2 0 0 2 2 2 0 NACHT domain NB-ARC PF00931.20 001082159.1_37929001_3 - 0.034 13.0 0.6 4 6.3 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain Mg_chelatase PF01078.19 001082159.1_37929001_3 - 0.043 13.0 0.0 3.2 6.9 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI tRNA_lig_kinase PF08303.9 001082159.1_37929001_3 - 0.047 13.6 0.1 15 5.5 0.0 3.1 3 0 0 3 3 2 0 tRNA ligase kinase domain DUF3487 PF11990.6 001082159.1_37929001_3 - 0.094 12.5 4.6 0.13 12.0 0.4 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) WD40 PF00400.30 001110430.1_49825001_3 - 9.7e-33 111.6 1.5 3.4e-06 27.6 0.0 6.9 6 0 0 6 6 6 6 WD domain, G-beta repeat CSTF1_dimer PF16699.3 001110430.1_49825001_3 - 4.4e-24 83.9 0.3 7.5e-24 83.1 0.3 1.4 1 0 0 1 1 1 1 Cleavage stimulation factor subunit 1, dimerisation domain ANAPC4_WD40 PF12894.5 001110430.1_49825001_3 - 1.2e-11 44.6 0.0 0.045 13.9 0.0 4.8 2 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.6 001110430.1_49825001_3 - 8.3e-06 24.3 0.1 0.00023 19.5 0.0 2.1 2 0 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz Ge1_WD40 PF16529.3 001110430.1_49825001_3 - 0.0028 16.5 0.6 0.51 9.1 0.1 2.7 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Agouti PF05039.10 001122939.1_37922001_1 - 1.8e-28 98.9 14.6 1.8e-28 98.9 14.6 1.6 2 0 0 2 2 2 1 Agouti protein Ank_2 PF12796.5 001101823.1_49828001_2 - 4.6e-40 135.9 2.4 1e-13 51.5 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.28 001101823.1_49828001_2 - 3.2e-36 122.1 5.0 6.5e-07 29.4 0.1 6.7 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.4 001101823.1_49828001_2 - 1.4e-32 111.5 4.5 1.6e-12 47.5 0.0 4.6 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.4 001101823.1_49828001_2 - 2.9e-30 103.7 10.0 5.1e-08 32.9 0.0 7.4 2 1 5 7 7 7 6 Ankyrin repeats (many copies) SET PF00856.26 001101823.1_49828001_2 - 4.5e-27 95.4 0.8 7e-24 85.0 0.1 2.8 2 0 0 2 2 2 2 SET domain Ank_3 PF13606.4 001101823.1_49828001_2 - 1.2e-26 89.6 6.6 0.00048 20.2 0.0 7.1 7 0 0 7 7 6 5 Ankyrin repeat Pre-SET PF05033.14 001101823.1_49828001_2 - 1.5e-15 57.6 15.6 1.5e-15 57.6 15.6 2.8 3 0 0 3 3 2 1 Pre-SET motif CDC45 PF02724.12 001101823.1_49828001_2 - 0.0044 15.3 19.3 0.0066 14.7 19.3 1.1 1 0 0 1 1 1 1 CDC45-like protein RNA_pol_3_Rpc31 PF11705.6 001101823.1_49828001_2 - 0.041 14.0 16.4 0.079 13.0 16.4 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 XRCC4 PF06632.10 001101823.1_49828001_2 - 0.099 11.3 15.3 0.18 10.5 15.3 1.3 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Nop14 PF04147.10 001101823.1_49828001_2 - 0.11 10.6 19.9 0.15 10.1 19.9 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.10 001101823.1_49828001_2 - 0.16 11.2 22.9 0.24 10.6 22.9 1.1 1 0 0 1 1 1 0 SDA1 Paf1 PF03985.11 001101823.1_49828001_2 - 0.25 10.1 20.5 0.38 9.6 20.5 1.1 1 0 0 1 1 1 0 Paf1 PA26 PF04636.11 001101823.1_49828001_2 - 0.55 9.0 3.1 0.84 8.3 3.1 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) IncA PF04156.12 001101823.1_49828001_2 - 0.78 9.4 11.4 1.4 8.5 11.4 1.3 1 0 0 1 1 1 0 IncA protein Protamine_P2 PF00841.17 001101823.1_49828001_2 - 1.8 9.0 10.7 4.5 7.7 10.7 1.6 1 0 0 1 1 1 0 Sperm histone P2 Cnd2 PF05786.12 001101823.1_49828001_2 - 2.1 6.7 15.2 2.9 6.3 15.2 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 DUF2052 PF09747.7 001101823.1_49828001_2 - 2.3 8.2 23.2 4.1 7.4 23.2 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CPSF100_C PF13299.4 001101823.1_49828001_2 - 2.5 8.1 6.7 4.8 7.2 6.7 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF913 PF06025.10 001101823.1_49828001_2 - 6.3 5.5 5.2 9.7 4.9 5.2 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Sporozoite_P67 PF05642.9 001101823.1_49828001_2 - 8.7 4.2 13.3 15 3.4 13.3 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen EOS1 PF12326.6 001009721.3_39522001_1 - 0.25 11.1 0.1 0.18 11.6 0.1 1.1 1 0 0 1 1 1 0 N-glycosylation protein Motilin_assoc PF04643.10 001009721.3_39522001_2 - 6.7e-31 105.8 0.2 9.9e-31 105.3 0.2 1.3 1 0 0 1 1 1 1 Motilin/ghrelin-associated peptide Motilin_ghrelin PF04644.10 001009721.3_39522001_2 - 3.7e-10 39.3 4.5 3.7e-10 39.3 4.5 3.9 2 1 0 2 2 2 1 Motilin/ghrelin SR-25 PF10500.7 001009721.3_39522001_2 - 0.51 9.8 36.1 0.85 9.1 36.1 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Presenilin PF01080.15 001009721.3_39522001_2 - 0.54 8.8 1.2 0.42 9.2 1.2 1.1 1 0 0 1 1 1 0 Presenilin RNA_polI_A34 PF08208.9 001009721.3_39522001_3 - 0.03 14.3 29.6 0.035 14.1 29.6 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Prominin PF05478.9 001077420.1_29628001_2 - 8.6e-298 989.6 2.3 1e-297 989.4 2.3 1.0 1 0 0 1 1 1 1 Prominin DUF2207 PF09972.7 001077420.1_29628001_2 - 0.0012 17.6 1.5 0.19 10.3 0.0 2.7 3 0 0 3 3 3 2 Predicted membrane protein (DUF2207) Baculo_PEP_C PF04513.10 001077420.1_29628001_2 - 0.0024 17.8 19.8 0.081 12.8 4.3 3.5 2 1 1 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus RasGAP_C PF03836.13 001077420.1_29628001_2 - 0.016 15.2 4.2 0.043 13.8 1.3 2.9 2 1 0 3 3 3 0 RasGAP C-terminus HemX PF04375.12 001077420.1_29628001_2 - 0.027 13.7 0.2 0.45 9.6 0.0 2.4 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF1043 PF06295.10 001077420.1_29628001_2 - 0.043 13.7 0.9 10 6.0 0.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1043) ApoLp-III PF07464.9 001077420.1_29628001_2 - 0.043 13.8 4.7 2.1 8.3 0.0 3.2 2 1 1 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Apolipoprotein PF01442.16 001077420.1_29628001_2 - 0.078 12.8 0.9 3.7 7.3 0.2 2.4 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain IncA PF04156.12 001077420.1_29628001_2 - 0.092 12.4 0.1 0.092 12.4 0.1 3.3 4 1 0 4 4 2 0 IncA protein DUF1218 PF06749.10 001077420.1_29628001_2 - 0.1 13.0 9.5 0.64 10.4 2.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) BRE1 PF08647.9 001077420.1_29628001_2 - 0.11 12.5 2.0 0.38 10.7 2.0 1.9 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase DUF1664 PF07889.10 001077420.1_29628001_2 - 0.16 11.8 6.7 2.7 7.9 0.3 3.4 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) TBPIP PF07106.11 001077420.1_29628001_2 - 0.18 11.5 3.6 17 5.0 0.0 2.7 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) CLZ PF16526.3 001077420.1_29628001_2 - 0.18 12.1 2.6 1.1 9.5 0.9 2.7 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels AIP3 PF03915.11 001077420.1_29628001_2 - 0.24 10.3 1.4 1.3 7.9 0.6 2.1 2 0 0 2 2 2 0 Actin interacting protein 3 DUF4446 PF14584.4 001077420.1_29628001_2 - 0.26 11.1 2.7 2.3 8.0 0.1 3.0 3 0 0 3 3 2 0 Protein of unknown function (DUF4446) TRPM_tetra PF16519.3 001077420.1_29628001_2 - 0.35 10.9 3.3 0.47 10.5 0.2 2.9 3 0 0 3 3 3 0 Tetramerisation domain of TRPM DUF948 PF06103.9 001077420.1_29628001_2 - 0.45 10.7 9.8 4 7.6 0.7 4.5 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) UPF0693 PF16088.3 001077420.1_29628001_2 - 0.45 10.7 5.6 0.21 11.8 2.3 2.1 2 0 0 2 2 1 0 UPF0693 family HIP1_clath_bdg PF16515.3 001077420.1_29628001_2 - 0.47 11.0 2.7 1.8 9.1 2.7 2.0 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Reo_sigmaC PF04582.10 001077420.1_29628001_2 - 0.85 8.8 11.3 0.19 10.9 2.4 2.8 2 1 1 3 3 3 0 Reovirus sigma C capsid protein APG17 PF04108.10 001077420.1_29628001_2 - 1.2 8.0 8.9 0.85 8.5 3.9 2.7 2 1 0 2 2 2 0 Autophagy protein Apg17 COG5 PF10392.7 001077420.1_29628001_2 - 2.2 8.3 6.8 0.71 9.9 1.0 2.9 3 0 0 3 3 3 0 Golgi transport complex subunit 5 Laminin_II PF06009.10 001077420.1_29628001_2 - 2.5 8.0 10.2 0.68 9.8 0.3 3.6 4 0 0 4 4 3 0 Laminin Domain II DUF4795 PF16043.3 001077420.1_29628001_2 - 8.1 5.8 7.7 3.5 7.1 1.6 3.1 3 1 1 4 4 4 0 Domain of unknown function (DUF4795) Baculo_11_kDa PF06143.9 001077420.1_29628001_2 - 9.7 5.7 8.8 7.8 6.0 0.0 3.7 3 1 1 4 4 4 0 Baculovirus 11 kDa family CBFD_NFYB_HMF PF00808.21 001144930.1_49826001_2 - 4.1e-28 97.3 0.6 6.1e-28 96.8 0.6 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.22 001144930.1_49826001_2 - 0.00015 22.1 0.0 0.00024 21.3 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.14 001144930.1_49826001_2 - 0.012 15.4 0.0 0.022 14.7 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit CENP-T_C PF15511.4 001144930.1_49826001_2 - 0.021 14.8 0.0 0.035 14.1 0.0 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold Reprolysin PF01421.17 001173096.1_09927001_3 - 3.8e-66 222.7 0.1 3.8e-66 222.7 0.1 2.2 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 001173096.1_09927001_3 - 5.3e-25 87.9 0.9 5.3e-25 87.9 0.9 3.9 3 2 1 4 4 4 1 ADAM cysteine-rich Pep_M12B_propep PF01562.17 001173096.1_09927001_3 - 5e-19 68.8 0.1 9.5e-19 67.9 0.1 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Disintegrin PF00200.21 001173096.1_09927001_3 - 2.8e-16 59.9 29.9 2.8e-16 59.9 29.9 4.4 4 0 0 4 4 4 1 Disintegrin Reprolysin_5 PF13688.4 001173096.1_09927001_3 - 4.8e-12 46.3 1.3 1.1e-11 45.2 1.3 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 001173096.1_09927001_3 - 1.3e-09 38.5 0.0 2.5e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 001173096.1_09927001_3 - 6e-05 22.7 0.2 0.00013 21.6 0.2 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.22 001173096.1_09927001_3 - 0.0064 16.0 0.2 0.012 15.0 0.2 1.4 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Reprolysin_2 PF13574.4 001173096.1_09927001_3 - 0.022 14.5 0.5 0.048 13.4 0.5 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.22 001173096.1_09927001_3 - 0.089 12.5 0.1 0.14 11.8 0.1 1.2 1 0 0 1 1 1 0 Matrixin DSHCT PF08148.10 001101817.1_49828001_2 - 1.3e-42 145.1 0.0 2.7e-42 144.1 0.0 1.5 1 0 0 1 1 1 1 DSHCT (NUC185) domain rRNA_proc-arch PF13234.4 001101817.1_49828001_2 - 1.4e-35 123.4 0.0 1.9e-35 122.9 0.0 1.2 1 0 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.27 001101817.1_49828001_2 - 1.2e-16 60.9 0.0 2.1e-16 60.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001101817.1_49828001_2 - 6.3e-06 26.4 0.0 1.3e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 001101817.1_49828001_2 - 0.00012 22.0 0.0 0.00022 21.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF3516 PF12029.6 001101817.1_49828001_2 - 0.068 12.1 0.2 0.11 11.4 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3516) MHC_II_alpha PF00993.18 001171118.1_37923001_1 - 1.7e-34 117.2 0.3 2.5e-34 116.7 0.3 1.2 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001171118.1_37923001_1 - 6.2e-29 99.0 1.0 6.2e-29 99.0 1.0 1.8 2 0 0 2 2 2 1 C1-set C-terminal domain C1-set PF07654.13 001171118.1_37923001_1 - 6.6e-22 77.7 0.0 1.1e-21 77.0 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001171118.1_37923001_1 - 8.5e-05 23.0 0.0 0.00015 22.2 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Marek_A PF02124.13 001171118.1_37923001_1 - 0.0078 15.9 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 Marek's disease glycoprotein A BC10 PF06726.10 001009852.1_22422001_3 - 4.3e-26 90.8 10.2 5.9e-26 90.4 10.2 1.2 1 0 0 1 1 1 1 Bladder cancer-related protein BC10 zf-C2H2 PF00096.24 001134352.2_49827001_1 - 9.3e-15 54.0 23.0 7.1e-06 26.1 2.7 4.3 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001134352.2_49827001_1 - 1.5e-13 50.4 13.8 1.5e-08 34.6 1.1 4.0 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 001134352.2_49827001_1 - 1.9e-05 24.9 26.5 0.0082 16.8 1.9 4.8 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.5 001134352.2_49827001_1 - 0.021 15.1 5.2 1.3 9.4 0.3 3.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 001134352.2_49827001_1 - 0.14 12.0 8.5 0.13 12.1 0.5 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger Cystatin PF00031.19 001081989.1_37921001_2 - 5.2e-19 68.2 0.1 6.1e-19 68.0 0.1 1.1 1 0 0 1 1 1 1 Cystatin domain Dynein_light PF01221.16 001081989.1_37921001_2 - 0.00029 21.0 0.0 0.0004 20.5 0.0 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 PHB_depo_C PF06850.9 001081989.1_37921001_2 - 0.041 13.2 0.0 0.052 12.9 0.0 1.1 1 0 0 1 1 1 0 PHB de-polymerase C-terminus Crystall PF00030.17 001172871.2_09922001_2 - 1e-59 198.5 8.8 1.8e-29 101.7 1.7 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 001172871.2_09922001_2 - 0.0097 15.7 3.8 0.15 11.9 0.1 2.7 3 0 0 3 3 3 2 Peptidase inhibitor family I36 Crystall_3 PF08964.8 001172871.2_09922001_2 - 0.23 11.5 2.8 1.8 8.7 0.1 2.7 2 1 0 2 2 2 0 Beta/Gamma crystallin IL8 PF00048.18 001285721.1_09023001_1 - 5.7e-13 48.7 0.6 9.9e-13 47.9 0.6 1.4 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Glyco_transf_7C PF02709.12 001168422.1_49823001_1 - 6.9e-27 92.8 0.1 1.2e-26 92.0 0.1 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_transf_7N PF13733.4 001168422.1_49823001_1 - 2.1e-23 82.3 0.0 3.5e-23 81.6 0.0 1.2 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_tranf_2_2 PF10111.7 001168422.1_49823001_1 - 0.02 14.3 0.0 2.6 7.3 0.0 2.1 2 0 0 2 2 2 0 Glycosyltransferase like family 2 Sushi PF00084.18 001172843.1_09923001_1 - 0.00031 21.2 0.4 0.00054 20.4 0.4 1.4 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) DUF5134 PF17197.2 001172843.1_09923001_1 - 0.004 16.9 0.3 0.0078 16.0 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5134) SKG6 PF08693.8 001172843.1_09923001_1 - 0.49 9.7 6.8 1.1 8.6 6.8 1.6 1 1 0 1 1 1 0 Transmembrane alpha-helix domain Pkinase_Tyr PF07714.15 001308594.1_39528001_1 - 6.6e-101 336.8 0.0 9.2e-101 336.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001308594.1_39528001_1 - 8.4e-42 143.2 0.0 6.3e-30 104.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.4 001308594.1_39528001_1 - 3.1e-23 82.0 8.4 9.3e-08 32.5 0.2 4.7 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.14 001308594.1_39528001_1 - 4.5e-15 55.3 8.2 6e-07 29.3 0.3 5.5 5 2 0 5 5 5 3 Immunoglobulin I-set domain ig PF00047.23 001308594.1_39528001_1 - 1.6e-13 50.5 14.4 1.6e-12 47.3 0.8 4.4 5 0 0 5 5 5 2 Immunoglobulin domain Ig_2 PF13895.4 001308594.1_39528001_1 - 3.2e-12 46.5 10.4 0.0019 18.3 0.3 5.4 5 1 0 5 5 5 4 Immunoglobulin domain C1-set PF07654.13 001308594.1_39528001_1 - 0.0009 19.5 0.4 0.0009 19.5 0.4 2.6 3 0 0 3 3 3 1 Immunoglobulin C1-set domain Ig_4 PF16680.3 001308594.1_39528001_1 - 0.0068 16.6 0.9 2.2 8.6 0.0 3.5 2 1 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain V-set PF07686.15 001308594.1_39528001_1 - 0.012 15.6 11.1 0.29 11.2 0.1 5.5 5 3 1 6 6 6 0 Immunoglobulin V-set domain APH PF01636.21 001308594.1_39528001_1 - 0.13 12.1 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family C2-set_2 PF08205.10 001308594.1_39528001_1 - 0.14 12.1 3.2 8.7 6.4 0.0 3.6 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain MHC_II_alpha PF00993.18 001159759.1_39523001_2 - 5.9e-35 118.7 0.0 8.3e-35 118.2 0.0 1.2 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001159759.1_39523001_2 - 3e-27 93.7 0.4 5.7e-27 92.7 0.4 1.5 1 0 0 1 1 1 1 C1-set C-terminal domain C1-set PF07654.13 001159759.1_39523001_2 - 7.1e-24 84.0 0.0 1.1e-23 83.4 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001159759.1_39523001_2 - 6.4e-06 26.6 0.0 1.1e-05 25.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Marek_A PF02124.13 001159759.1_39523001_2 - 0.00099 18.9 0.0 0.0015 18.3 0.0 1.1 1 0 0 1 1 1 1 Marek's disease glycoprotein A C2-set_2 PF08205.10 001159759.1_39523001_2 - 0.0091 15.9 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Hormone_1 PF00103.18 022537.1_45722001_2 - 3.3e-58 196.8 2.5 4.1e-58 196.5 2.5 1.1 1 0 0 1 1 1 1 Somatotropin hormone family FXa_inhibition PF14670.4 001082144.1_37927001_2 - 6.4e-17 61.4 76.0 2.5e-05 24.3 5.8 7.1 4 1 2 6 6 6 5 Coagulation Factor Xa inhibitory site Tme5_EGF_like PF09064.8 001082144.1_37927001_2 - 1e-14 53.9 8.0 1e-14 53.9 8.0 5.8 6 0 0 6 6 6 2 Thrombomodulin like fifth domain, EGF-like cEGF PF12662.5 001082144.1_37927001_2 - 6.8e-13 48.2 35.1 7.6e-06 25.6 0.5 6.7 6 0 0 6 6 6 5 Complement Clr-like EGF-like EGF_CA PF07645.13 001082144.1_37927001_2 - 4.5e-09 36.2 70.7 3.8e-07 30.1 5.9 6.6 4 1 2 6 6 6 3 Calcium-binding EGF domain Lectin_C PF00059.19 001082144.1_37927001_2 - 8.8e-08 32.7 0.0 1.5e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 Lectin C-type domain EGF PF00008.25 001082144.1_37927001_2 - 0.0046 17.1 82.2 0.053 13.7 6.3 7.1 6 0 0 6 6 6 4 EGF-like domain Transposase_1 PF01359.16 001285573.2_09024001_1 - 5.7e-23 80.4 0.2 1.1e-22 79.5 0.2 1.5 1 0 0 1 1 1 1 Transposase (partial DDE domain) HTH_24 PF13412.4 001285573.2_09024001_1 - 0.0072 15.7 0.1 0.013 14.9 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding AA_permease_2 PF13520.4 001110171.1_49824001_1 - 1.5e-63 215.0 46.1 1.9e-63 214.7 46.1 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.19 001110171.1_49824001_1 - 3.5e-24 85.1 42.4 5.1e-24 84.6 42.4 1.2 1 0 0 1 1 1 1 Amino acid permease LRR_8 PF13855.4 001048186.2_49825001_1 - 4.1e-92 301.8 50.6 6.9e-17 60.8 0.2 10.3 3 2 8 11 11 11 9 Leucine rich repeat LRR_4 PF12799.5 001048186.2_49825001_1 - 2.3e-36 122.9 38.6 8e-05 22.8 0.1 12.0 9 3 4 13 13 13 12 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001048186.2_49825001_1 - 6.7e-24 84.1 0.0 1.1e-06 28.5 0.0 4.1 1 1 4 5 5 5 5 Leucine rich repeats (6 copies) LRR_1 PF00560.31 001048186.2_49825001_1 - 1.1e-13 49.3 45.5 7.1 7.4 0.5 17.1 17 2 0 17 17 17 5 Leucine Rich Repeat LRR_9 PF14580.4 001048186.2_49825001_1 - 4.3e-13 49.0 4.1 0.015 14.6 0.0 5.6 1 1 4 6 6 6 5 Leucine-rich repeat LRRNT PF01462.16 001048186.2_49825001_1 - 4.3e-09 35.7 2.1 1.2e-08 34.3 2.1 1.9 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain Herpes_BTRF1 PF04682.10 001048186.2_49825001_1 - 0.0034 16.6 0.2 0.11 11.7 0.0 2.4 2 0 0 2 2 2 1 Herpesvirus BTRF1 protein conserved region IL8 PF00048.18 001172838.2_09922001_1 - 1.8e-19 69.5 5.0 3.6e-19 68.5 5.0 1.5 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like ADAM_CR PF08516.10 001173101.1_09925001_1 - 1.6e-29 102.5 9.3 1.6e-29 102.5 9.3 3.2 3 1 1 4 4 4 1 ADAM cysteine-rich Disintegrin PF00200.21 001173101.1_09925001_1 - 3.5e-17 62.8 24.6 3.5e-17 62.8 24.6 4.1 4 1 0 4 4 4 1 Disintegrin Pep_M12B_propep PF01562.17 001173101.1_09925001_1 - 1.2e-15 57.9 0.0 3.1e-15 56.5 0.0 1.7 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin PF01421.17 001173101.1_09925001_1 - 2.5e-14 53.5 0.0 2.5e-14 53.5 0.0 1.9 3 0 0 3 3 3 1 Reprolysin (M12B) family zinc metalloprotease zf-C2H2 PF00096.24 001190250.1_49827001_1 - 3e-13 49.3 24.4 7.3e-05 22.9 5.5 4.0 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001190250.1_49827001_1 - 3.8e-09 36.5 8.7 1.4e-06 28.3 1.8 3.7 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 001190250.1_49827001_1 - 9.8e-05 22.7 25.7 0.021 15.5 3.0 4.4 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.5 001190250.1_49827001_1 - 0.51 10.7 8.6 0.31 11.4 1.1 3.0 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Ion_trans PF00520.29 001173032.2_09926001_2 - 9e-36 123.2 15.7 1.4e-35 122.6 15.7 1.2 1 0 0 1 1 1 1 Ion transport protein TRP_2 PF08344.9 001173032.2_09926001_2 - 1.2e-26 92.5 1.0 2.5e-26 91.5 1.0 1.6 1 0 0 1 1 1 1 Transient receptor ion channel II PKD_channel PF08016.10 001173032.2_09926001_2 - 3.6e-14 52.2 14.1 5.6e-14 51.5 14.1 1.2 1 0 0 1 1 1 1 Polycystin cation channel Ank_2 PF12796.5 001173032.2_09926001_2 - 5e-11 42.9 0.4 3e-07 30.8 0.3 2.7 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001173032.2_09926001_2 - 3e-05 24.1 1.2 0.061 13.6 0.2 4.3 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.4 001173032.2_09926001_2 - 7.9e-05 23.0 0.8 0.0019 18.6 0.1 3.0 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 001173032.2_09926001_2 - 0.00045 20.3 2.7 9.4 7.0 0.0 5.0 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.28 001173032.2_09926001_2 - 0.013 15.8 1.1 13 6.3 0.0 3.5 3 0 0 3 3 3 0 Ankyrin repeat ING PF12998.5 001173032.2_09926001_2 - 2.4 8.7 12.3 2 8.9 5.3 3.2 3 1 1 4 4 4 0 Inhibitor of growth proteins N-terminal histone-binding Baculo_11_kDa PF06143.9 001173032.2_09926001_2 - 7 6.2 6.6 1.9 8.0 0.8 2.5 2 0 0 2 2 2 0 Baculovirus 11 kDa family bZIP_1 PF00170.19 001123103.1_49826001_2 - 1.3e-09 37.9 16.5 2.7e-09 36.8 16.5 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 001123103.1_49826001_2 - 7.1e-06 25.9 14.5 7.1e-06 25.9 14.5 2.1 2 1 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.15 001123103.1_49826001_2 - 0.0027 18.1 9.9 0.0027 18.1 9.9 2.0 2 0 0 2 2 2 1 bZIP Maf transcription factor DUF4407 PF14362.4 001123103.1_49826001_2 - 0.0051 16.1 0.0 0.0095 15.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) GIT_CC PF16559.3 001123103.1_49826001_2 - 0.0064 16.4 2.2 0.014 15.3 2.2 1.5 1 0 0 1 1 1 1 GIT coiled-coil Rho guanine nucleotide exchange factor ZapB PF06005.10 001123103.1_49826001_2 - 0.014 15.7 4.6 0.037 14.3 4.6 1.7 1 0 0 1 1 1 0 Cell division protein ZapB DUF972 PF06156.11 001123103.1_49826001_2 - 0.042 14.3 1.1 0.078 13.5 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF972) NYD-SP28_assoc PF14775.4 001123103.1_49826001_2 - 1.3 9.0 4.1 2.8 8.0 4.1 1.5 1 0 0 1 1 1 0 Sperm tail C-terminal domain PDEase_I PF00233.17 001123159.1_49827001_1 - 5.6e-94 314.2 2.9 8.9e-94 313.5 2.9 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase UDPGT PF00201.16 001173113.1_09926001_2 - 7.2e-245 813.3 0.2 9.2e-245 813.0 0.2 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001173113.1_09926001_2 - 6.4e-08 32.6 0.0 1.1e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_4_2 PF13477.4 001173113.1_09926001_2 - 0.016 15.1 0.0 0.43 10.5 0.0 2.2 1 1 0 2 2 2 0 Glycosyl transferase 4-like ig PF00047.23 001172870.1_09924001_3 - 1.4e-11 44.3 0.4 2.2e-11 43.6 0.4 1.3 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 001172870.1_09924001_3 - 0.0023 17.9 0.2 0.0041 17.1 0.2 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001172870.1_09924001_3 - 0.0036 17.8 0.2 0.0073 16.8 0.2 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001172870.1_09924001_3 - 0.093 12.7 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain Y_phosphatase PF00102.25 001170980.1_37928001_2 - 1.4e-83 280.0 1.7 2.2e-83 279.3 1.7 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.19 001170980.1_37928001_2 - 5.2e-07 29.8 0.1 1.6e-06 28.2 0.1 1.8 2 0 0 2 2 2 1 Fibronectin type III domain Y_phosphatase3 PF13350.4 001170980.1_37928001_2 - 3.6e-05 23.7 0.0 5.6e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.18 001170980.1_37928001_2 - 0.00011 21.9 0.0 0.00024 20.8 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 001170980.1_37928001_2 - 0.00057 19.9 0.1 0.0016 18.5 0.1 1.8 1 1 0 1 1 1 1 Inositol hexakisphosphate Cu_amine_oxid PF01179.18 199095.1_45726001_1 - 3.4e-87 292.9 2.7 4.4e-87 292.5 2.7 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.14 199095.1_45726001_1 - 5.2e-22 77.8 0.0 1.1e-21 76.8 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.14 199095.1_45726001_1 - 8.3e-12 45.3 0.0 1.6e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain DUF1965 PF09248.8 199095.1_45726001_1 - 5.4e-07 29.2 0.1 3.4e-06 26.6 0.0 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF1965) Proteasome PF00227.24 001144902.1_49822001_3 - 8.4e-43 145.9 0.0 9.7e-43 145.7 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit zf-C2H2 PF00096.24 001134353.2_49828001_1 - 3e-10 39.8 37.1 0.00045 20.4 8.9 4.6 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001134353.2_49828001_1 - 9.5e-08 32.0 14.0 1.6e-05 25.0 6.6 4.2 5 0 0 5 5 5 2 Zinc-finger double domain Mit_proteolip PF08039.9 001134353.2_49828001_1 - 0.066 13.4 2.2 0.15 12.3 2.2 1.5 1 0 0 1 1 1 0 Mitochondrial proteolipid zf-C2H2_4 PF13894.4 001134353.2_49828001_1 - 0.15 12.8 38.0 0.054 14.2 7.1 4.6 4 0 0 4 4 4 0 C2H2-type zinc finger LRR_8 PF13855.4 001285686.2_09027001_1 - 5.2e-82 269.4 75.7 4.1e-10 39.1 0.1 15.1 11 3 2 14 14 14 14 Leucine rich repeat LRR_4 PF12799.5 001285686.2_09027001_1 - 3.3e-38 128.8 69.4 0.0014 18.8 0.2 15.8 8 3 10 18 18 18 16 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001285686.2_09027001_1 - 2.4e-13 48.4 66.4 0.83 10.2 0.0 21.9 22 4 0 22 22 22 4 Leucine Rich Repeat LRR_6 PF13516.4 001285686.2_09027001_1 - 3.4e-08 32.8 70.6 0.38 10.8 0.0 19.9 22 0 0 22 22 22 3 Leucine Rich repeat LRR_9 PF14580.4 001285686.2_09027001_1 - 4.4e-05 22.9 20.2 0.53 9.6 0.3 7.1 5 3 2 7 7 7 2 Leucine-rich repeat TIR PF01582.18 001285686.2_09027001_1 - 5.7e-05 22.9 0.0 9.8e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 TIR domain LRR_5 PF13306.4 001285686.2_09027001_1 - 0.00014 21.7 0.0 0.88 9.4 0.0 3.9 4 0 0 4 4 4 2 Leucine rich repeats (6 copies) FNIP PF05725.10 001285686.2_09027001_1 - 0.0029 17.6 2.5 8.7 6.5 0.0 5.3 4 2 1 5 5 5 1 FNIP Repeat CDC37_M PF08565.9 001123096.1_49824001_2 - 1.7e-27 95.5 0.7 3.4e-27 94.6 0.4 1.6 1 1 0 1 1 1 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.8 001123096.1_49824001_2 - 1.3e-15 57.2 0.0 1.3e-15 57.2 0.0 3.5 3 1 0 3 3 3 1 Cdc37 C terminal domain CDC37_N PF03234.12 001123096.1_49824001_2 - 2.5e-14 54.2 19.3 2.5e-14 54.1 14.8 2.6 2 1 1 3 3 3 1 Cdc37 N terminal kinase binding ARGLU PF15346.4 001123096.1_49824001_2 - 0.015 15.0 18.2 0.015 15.0 18.2 3.1 2 1 1 3 3 3 0 Arginine and glutamate-rich 1 Med4 PF10018.7 001123096.1_49824001_2 - 0.059 12.9 12.7 0.023 14.2 1.7 2.7 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 T3SSipB PF16535.3 001123096.1_49824001_2 - 0.2 12.0 5.9 0.042 14.2 1.4 2.0 2 1 0 2 2 2 0 Type III cell invasion protein SipB Atg14 PF10186.7 001123096.1_49824001_2 - 1.6 7.6 8.3 2.7 6.8 8.3 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CRT10 PF08728.8 001123096.1_49824001_2 - 1.7 6.6 6.5 2.7 6.0 6.5 1.2 1 0 0 1 1 1 0 CRT10 DUF4407 PF14362.4 001123096.1_49824001_2 - 1.9 7.7 6.4 0.76 8.9 3.9 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) PIG-F PF06699.9 001280695.1_39522001_1 - 2.7e-45 154.6 9.6 3.6e-45 154.2 9.6 1.1 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F RRM_1 PF00076.20 001105312.1_49825001_3 - 6e-18 64.3 0.0 2e-17 62.6 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001105312.1_49825001_3 - 0.0039 17.1 0.0 0.0071 16.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif Ribosomal_S8e PF01201.20 001280697.1_39522001_3 - 5.8e-63 211.0 1.0 5.8e-63 211.0 1.0 2.0 2 0 0 2 2 2 1 Ribosomal protein S8e ETRAMP PF09716.8 001280697.1_39522001_3 - 0.39 10.7 7.4 2.7 8.0 1.8 2.3 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Hormone_1 PF00103.18 001112814.1_39522001_1 - 1.3e-43 149.2 0.9 1.9e-43 148.6 0.9 1.2 1 0 0 1 1 1 1 Somatotropin hormone family Hormone_1 PF00103.18 001112814.1_39522001_3 - 4e-15 56.0 2.0 5.5e-15 55.6 2.0 1.1 1 0 0 1 1 1 1 Somatotropin hormone family adh_short PF00106.23 001197021.2_49824001_1 - 1.4e-35 122.4 0.6 2.1e-35 121.8 0.6 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001197021.2_49824001_1 - 2.1e-30 105.9 0.7 3.1e-30 105.4 0.7 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase SCP2 PF02036.15 001197021.2_49824001_1 - 7.2e-23 80.9 0.1 1.4e-22 80.0 0.1 1.4 1 0 0 1 1 1 1 SCP-2 sterol transfer family KR PF08659.8 001197021.2_49824001_1 - 2.2e-05 24.3 1.3 2.8e-05 24.0 0.3 1.6 2 0 0 2 2 2 1 KR domain NAD_binding_3 PF03447.14 001197021.2_49824001_1 - 0.0097 16.4 1.3 5.6 7.5 0.1 2.3 1 1 1 2 2 2 2 Homoserine dehydrogenase, NAD binding domain Alkyl_sulf_C PF14864.4 001197021.2_49824001_1 - 0.01 16.0 0.0 0.017 15.2 0.0 1.4 1 0 0 1 1 1 0 Alkyl sulfatase C-terminal THF_DHG_CYH_C PF02882.17 001197021.2_49824001_1 - 0.044 13.0 0.1 0.1 11.8 0.1 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain p450 PF00067.20 214420.1_49824001_2 - 1.1e-159 531.9 0.0 1.3e-159 531.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 MAPEG PF01124.16 001038631.1_49823001_2 - 1.8e-23 82.8 0.4 2.6e-23 82.2 0.4 1.2 1 0 0 1 1 1 1 MAPEG family p450 PF00067.20 001173095.1_09926001_1 - 2.5e-97 326.4 0.1 3e-97 326.2 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 APOC4 PF15119.4 001082365.2_37922001_1 - 1e-49 166.6 0.0 1.3e-49 166.2 0.0 1.1 1 0 0 1 1 1 1 Apolipoprotein C4 Fer4 PF00037.25 001009427.1_39522001_2 - 0.38 10.5 3.4 0.35 10.6 1.6 1.9 2 0 0 2 2 2 0 4Fe-4S binding domain IL8 PF00048.18 001009427.1_39522001_3 - 2.3e-12 46.7 0.4 4.1e-12 45.9 0.4 1.3 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Glycolytic PF00274.17 001009809.1_39524001_2 - 1.2e-175 583.2 0.2 1.4e-175 583.0 0.2 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I DUF1658 PF07871.9 001009809.1_39524001_3 - 4.7 7.2 5.8 2.5 8.0 0.5 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1658) TMEM154 PF15102.4 001306112.1_39522001_1 - 1e-48 164.8 2.7 1.2e-48 164.5 2.7 1.1 1 0 0 1 1 1 1 TMEM154 protein family DUF3377 PF11857.6 001306112.1_39522001_1 - 0.015 15.1 0.2 0.034 13.9 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) DUF4834 PF16118.3 001306112.1_39522001_1 - 0.1 13.5 0.2 0.15 12.9 0.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) DUF2207 PF09972.7 001306112.1_39522001_1 - 0.17 10.5 0.0 0.19 10.4 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) RPEL PF02755.13 001110176.1_49825001_2 - 4.1e-21 73.9 19.5 1.3e-06 27.8 3.2 4.6 4 0 0 4 4 4 4 RPEL repeat Sod_Ni PF09055.9 001110176.1_49825001_2 - 0.043 14.3 1.2 0.086 13.3 1.2 1.4 1 0 0 1 1 1 0 Nickel-containing superoxide dismutase TF_AP-2 PF03299.12 001123201.1_49827001_2 - 4.3e-87 291.0 0.0 6.4e-87 290.5 0.0 1.3 1 0 0 1 1 1 1 Transcription factor AP-2 Gal-bind_lectin PF00337.20 001082713.1_37923001_2 - 4.4e-79 262.4 0.0 3.2e-39 133.4 0.0 2.1 2 0 0 2 2 2 2 Galactoside-binding lectin Cys_knot PF00007.20 001172830.2_09921001_2 - 4.7e-33 113.5 5.5 5.4e-33 113.3 5.5 1.0 1 0 0 1 1 1 1 Cystine-knot domain p450 PF00067.20 001267751.1_08024001_2 - 1.3e-145 485.6 0.0 1.5e-145 485.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pribosyltran PF00156.25 001105671.1_37923001_2 - 8.3e-22 77.3 0.0 1.2e-21 76.7 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.4 001105671.1_37923001_2 - 0.16 11.2 0.0 0.27 10.5 0.0 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase DUF1515 PF07439.9 001185166.1_49823001_1 - 0.077 12.9 2.4 19 5.2 0.0 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1515) XhlA PF10779.7 001185166.1_49823001_1 - 2.4 8.3 15.9 20 5.3 0.1 5.0 4 1 0 5 5 5 0 Haemolysin XhlA Atg14 PF10186.7 001185166.1_49823001_1 - 3.2 6.6 9.5 7 5.5 8.9 1.7 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Med9 PF07544.11 001185166.1_49823001_1 - 8.6 6.4 9.3 4.2 7.4 1.2 3.4 3 1 1 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 DUF1664 PF07889.10 001185166.1_49823001_1 - 9.6 6.1 7.5 2 8.3 1.1 2.8 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) ICAM_N PF03921.12 213816.1_49825001_3 - 1e-27 95.5 0.4 1.5e-26 91.8 0.0 2.8 3 0 0 3 3 3 1 Intercellular adhesion molecule (ICAM), N-terminal domain Ig_2 PF13895.4 213816.1_49825001_3 - 6.8e-16 58.3 7.8 0.00028 21.0 0.1 5.6 6 0 0 6 6 6 3 Immunoglobulin domain Ig_3 PF13927.4 213816.1_49825001_3 - 1.5e-09 38.2 13.5 0.0038 17.7 0.4 6.4 6 2 0 6 6 6 3 Immunoglobulin domain C2-set_2 PF08205.10 213816.1_49825001_3 - 3.8e-07 29.9 3.7 0.014 15.3 0.0 4.3 4 1 0 4 4 4 2 CD80-like C2-set immunoglobulin domain I-set PF07679.14 213816.1_49825001_3 - 2.8e-06 27.2 1.5 8.8 6.3 0.0 5.6 5 0 0 5 5 5 2 Immunoglobulin I-set domain ig PF00047.23 213816.1_49825001_3 - 3e-06 27.2 8.1 1.4 9.0 0.0 6.9 7 1 0 7 7 7 1 Immunoglobulin domain Tubulin PF00091.23 001113696.1_49827001_2 - 2.2e-68 230.2 0.0 3.1e-68 229.7 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 001113696.1_49827001_2 - 6.4e-39 132.9 0.0 9.9e-39 132.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.7 001113696.1_49827001_2 - 5.1e-05 23.4 0.0 9.3e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.4 001113696.1_49827001_2 - 0.046 12.8 0.0 0.078 12.0 0.0 1.2 1 0 0 1 1 1 0 Tubulin like Tubulin_3 PF14881.4 001113696.1_49827001_2 - 0.054 13.0 0.0 0.092 12.3 0.0 1.3 1 0 0 1 1 1 0 Tubulin domain zf-C2H2 PF00096.24 001134344.2_49826001_2 - 3.1e-11 42.9 28.5 0.00027 21.1 3.1 4.3 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001134344.2_49826001_2 - 4.7e-11 42.5 20.4 1.7e-06 28.1 1.5 4.2 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 001134344.2_49826001_2 - 3.1e-08 33.6 21.3 0.0056 17.3 1.7 4.3 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_8 PF15909.3 001134344.2_49826001_2 - 0.048 13.8 7.8 0.13 12.5 7.3 2.0 1 1 1 2 2 2 0 C2H2-type zinc ribbon FOXP-CC PF16159.3 001134344.2_49826001_2 - 0.18 12.3 7.7 5 7.7 0.2 3.3 1 1 2 3 3 3 0 FOXP coiled-coil domain zf-Di19 PF05605.10 001134344.2_49826001_2 - 0.3 11.3 5.3 0.42 10.8 0.9 2.8 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.4 001134344.2_49826001_2 - 7.4 6.5 16.6 0.19 11.6 0.8 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger Mob1_phocein PF03637.15 001032379.1_49825001_1 - 1.3e-32 113.0 0.8 2.1e-32 112.3 0.8 1.3 1 0 0 1 1 1 1 Mob1/phocein family ELO PF01151.16 001285628.1_09026001_3 - 1e-63 215.0 23.5 1.4e-63 214.6 23.5 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family Ribosomal_S17e PF00833.16 001280688.1_39521001_3 - 4e-70 233.2 0.6 4.9e-70 233.0 0.6 1.1 1 0 0 1 1 1 1 Ribosomal S17 G-patch PF01585.21 001145383.1_49824001_1 - 8.4e-14 51.1 0.8 8.4e-14 51.1 0.8 1.8 2 0 0 2 2 2 1 G-patch domain Ank_2 PF12796.5 001145383.1_49824001_1 - 2.2e-05 24.8 0.0 3.5e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001145383.1_49824001_1 - 0.00022 21.6 0.0 0.00047 20.5 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.4 001145383.1_49824001_1 - 0.002 18.4 0.4 0.0035 17.6 0.4 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 001145383.1_49824001_1 - 0.0023 18.1 0.0 0.0086 16.4 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeat G-patch_2 PF12656.5 001145383.1_49824001_1 - 0.018 15.0 0.3 0.042 13.8 0.3 1.6 1 0 0 1 1 1 0 G-patch domain zf-DBF PF07535.10 001145383.1_49824001_1 - 0.04 13.9 0.2 0.065 13.2 0.2 1.3 1 0 0 1 1 1 0 DBF zinc finger zf-C2H2_jaz PF12171.6 001145383.1_49824001_1 - 0.2 11.9 0.3 0.43 10.8 0.3 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Pou PF00157.15 001099957.1_37923001_2 - 4e-38 129.1 1.1 7.5e-38 128.3 1.1 1.5 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 001099957.1_37923001_2 - 1.1e-18 66.6 0.6 2.1e-18 65.7 0.6 1.5 1 0 0 1 1 1 1 Homeobox domain DUF521 PF04412.11 001099957.1_37923001_2 - 0.13 10.8 0.1 0.22 10.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF521) N_Asn_amidohyd PF14736.4 214042.1_49823001_1 - 5.8e-121 402.6 0.0 6.7e-121 402.4 0.0 1.0 1 0 0 1 1 1 1 Protein N-terminal asparagine amidohydrolase FIST PF08495.8 214042.1_49823001_1 - 0.065 13.1 0.0 0.094 12.6 0.0 1.2 1 0 0 1 1 1 0 FIST N domain PHD PF00628.27 038150.1_26228120_1 - 0.00062 19.5 3.0 0.00062 19.5 3.0 2.1 2 0 0 2 2 2 1 PHD-finger DEAD PF00270.27 136717.1_26229120_1 - 3.2e-50 170.2 0.0 7.2e-50 169.0 0.0 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 136717.1_26229120_1 - 4.5e-30 104.1 0.0 7.7e-30 103.4 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 136717.1_26229120_1 - 0.0046 16.8 0.0 0.0073 16.2 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Ax_dynein_light PF10211.7 073544.1_26227120_1 - 3.2e-08 33.6 8.4 3.2e-08 33.6 8.4 4.4 4 0 0 4 4 4 1 Axonemal dynein light chain His_Phos_2 PF00328.20 136634.1_26226120_1 - 4e-08 32.9 0.1 0.00083 18.7 0.0 2.2 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) His_Phos_2 PF00328.20 136634.1_26226120_3 - 3.7e-08 33.0 0.0 5.5e-08 32.4 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) WD40 PF00400.30 073602.1_43525120_3 - 3.5e-09 37.0 3.1 1.8 9.5 0.1 6.7 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 073602.1_43525120_3 - 0.00043 20.4 0.1 2.6 8.3 0.0 4.2 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain TIR PF01582.18 001009863.2_22424001_1 - 2.6e-39 134.7 0.1 2e-38 131.8 0.0 2.1 2 0 0 2 2 2 1 TIR domain Ig_2 PF13895.4 001009863.2_22424001_1 - 6.7e-15 55.1 4.8 1.1e-06 28.7 0.9 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 001009863.2_22424001_1 - 4.7e-12 45.9 1.3 0.0073 16.3 0.0 4.2 3 1 0 3 3 3 3 Immunoglobulin V-set domain Ig_3 PF13927.4 001009863.2_22424001_1 - 5.4e-12 46.0 2.0 1.7e-05 25.2 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 001009863.2_22424001_1 - 2.4e-10 40.2 0.7 0.00038 20.3 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.23 001009863.2_22424001_1 - 4.6e-09 36.2 2.5 0.053 13.6 0.1 3.4 3 0 0 3 3 3 3 Immunoglobulin domain TIR_2 PF13676.4 001009863.2_22424001_1 - 6.7e-05 23.0 0.0 0.00028 21.1 0.0 1.9 2 0 0 2 2 2 1 TIR domain C1-set PF07654.13 001009863.2_22424001_1 - 0.053 13.9 0.8 1.2 9.5 0.0 2.5 2 0 0 2 2 2 0 Immunoglobulin C1-set domain Ig_5 PF16681.3 001009863.2_22424001_1 - 0.88 9.9 10.7 2.7 8.3 0.2 3.8 2 2 0 3 3 3 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain zf-C2H2 PF00096.24 001173444.2_22426001_1 - 1.9e-15 56.2 21.8 2.4e-05 24.4 2.9 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001173444.2_22426001_1 - 8.5e-10 38.5 11.2 8.5e-07 29.0 3.4 4.0 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 001173444.2_22426001_1 - 3.4e-07 30.4 19.8 0.028 15.1 2.7 4.1 3 0 0 3 3 3 3 C2H2-type zinc finger FOXP-CC PF16159.3 001173444.2_22426001_1 - 1.2 9.7 5.3 21 5.7 2.0 2.6 1 1 1 2 2 2 0 FOXP coiled-coil domain LRR_8 PF13855.4 001130427.1_29627001_1 - 1e-76 252.4 109.5 2.9e-10 39.6 1.3 14.9 9 5 6 15 15 15 14 Leucine rich repeat LRR_4 PF12799.5 001130427.1_29627001_1 - 4.5e-39 131.5 112.2 9.7e-06 25.7 0.2 15.5 8 4 11 19 19 19 18 Leucine Rich repeats (2 copies) TIR PF01582.18 001130427.1_29627001_1 - 2.8e-16 59.7 0.6 6.3e-16 58.5 0.6 1.6 1 0 0 1 1 1 1 TIR domain LRR_1 PF00560.31 001130427.1_29627001_1 - 1.6e-12 45.9 96.4 0.76 10.3 0.0 22.2 21 4 0 21 21 21 7 Leucine Rich Repeat LRR_5 PF13306.4 001130427.1_29627001_1 - 2e-10 40.6 31.3 0.00069 19.5 0.2 8.3 2 2 4 8 8 8 7 Leucine rich repeats (6 copies) TIR_2 PF13676.4 001130427.1_29627001_1 - 1.5e-06 28.4 0.1 3.3e-06 27.2 0.1 1.6 1 0 0 1 1 1 1 TIR domain LRR_9 PF14580.4 001130427.1_29627001_1 - 5.4e-05 22.6 48.2 0.62 9.4 0.6 8.7 3 3 5 9 9 9 6 Leucine-rich repeat Wtap PF17098.3 001244242.1_49824001_1 - 8.6e-28 97.1 2.8 1.5e-27 96.3 2.8 1.4 1 0 0 1 1 1 1 WTAP/Mum2p family GM_CSF PF01109.15 001032949.2_29621001_3 - 2.7e-68 227.6 0.1 3.2e-68 227.4 0.1 1.0 1 0 0 1 1 1 1 Granulocyte-macrophage colony-stimulating factor ubiquitin PF00240.21 001130843.2_22422001_1 - 5e-33 112.5 0.1 2.9e-20 71.7 0.0 2.1 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.6 001130843.2_22422001_1 - 3.1e-09 36.4 0.0 1.8e-06 27.5 0.0 2.1 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 001130843.2_22422001_1 - 0.00046 20.4 0.1 0.15 12.4 0.0 3.0 2 1 0 2 2 2 1 Ubiquitin-like domain DWNN PF08783.9 001130843.2_22422001_1 - 0.014 15.5 0.0 4.4 7.5 0.0 2.3 2 0 0 2 2 2 0 DWNN domain FeoA PF04023.12 001130843.2_22422001_1 - 0.1 12.8 0.0 0.38 10.9 0.0 2.0 2 1 0 2 2 2 0 FeoA domain CNPase PF05881.10 001035528.2_29627001_1 - 9e-122 404.9 0.0 1.3e-121 404.5 0.0 1.2 1 0 0 1 1 1 1 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase) AAA_33 PF13671.4 001035528.2_29627001_1 - 1.2e-07 31.9 0.0 2.3e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain 6PF2K PF01591.16 001035528.2_29627001_1 - 0.00014 21.1 0.1 0.1 11.8 0.1 2.1 1 1 0 1 1 1 1 6-phosphofructo-2-kinase AAA_22 PF13401.4 001035528.2_29627001_1 - 0.0017 18.5 1.0 0.031 14.4 1.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 001035528.2_29627001_1 - 0.0026 18.0 0.0 0.0048 17.1 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.27 001035528.2_29627001_1 - 0.0041 17.4 0.0 0.007 16.7 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.10 001035528.2_29627001_1 - 0.0059 15.8 0.0 0.012 14.8 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin KTI12 PF08433.8 001035528.2_29627001_1 - 0.0063 15.9 0.0 0.0095 15.3 0.0 1.1 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_17 PF13207.4 001035528.2_29627001_1 - 0.014 15.7 0.0 0.026 14.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.10 001035528.2_29627001_1 - 0.016 15.0 0.0 0.031 14.1 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.4 001035528.2_29627001_1 - 0.035 14.5 0.0 0.059 13.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.4 001035528.2_29627001_1 - 0.035 13.7 0.0 0.078 12.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.25 001035528.2_29627001_1 - 0.038 14.4 0.0 0.071 13.5 0.0 1.4 1 0 0 1 1 1 0 ABC transporter NB-ARC PF00931.20 001035528.2_29627001_1 - 0.22 10.4 0.8 1.5 7.6 0.0 2.2 2 1 1 3 3 3 0 NB-ARC domain IncA PF04156.12 001280216.1_39726001_2 - 0.00093 18.9 0.0 0.0015 18.2 0.0 1.2 1 0 0 1 1 1 1 IncA protein EphA2_TM PF14575.4 001280216.1_39726001_2 - 0.0012 19.5 0.1 0.0021 18.7 0.1 1.4 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain DAP10 PF07213.9 001280216.1_39726001_2 - 0.079 12.8 1.0 0.32 10.8 0.1 2.3 2 0 0 2 2 2 0 DAP10 membrane protein LRR_8 PF13855.4 001144866.2_39728001_2 - 5.4e-88 288.6 72.1 2.3e-11 43.1 0.0 15.0 9 4 7 16 16 16 15 Leucine rich repeat LRR_4 PF12799.5 001144866.2_39728001_2 - 2.3e-49 164.2 56.2 0.00021 21.5 0.1 14.8 9 4 4 15 15 15 15 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001144866.2_39728001_2 - 3.3e-19 66.2 61.1 0.45 11.0 0.2 22.2 22 4 1 23 23 23 4 Leucine Rich Repeat LRR_6 PF13516.4 001144866.2_39728001_2 - 7.6e-10 37.9 74.8 1.6 8.9 0.8 19.2 22 0 0 22 22 22 8 Leucine Rich repeat TIR PF01582.18 001144866.2_39728001_2 - 1e-06 28.6 0.0 1.6e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 TIR domain LRR_9 PF14580.4 001144866.2_39728001_2 - 3.4e-06 26.6 9.5 0.41 10.0 0.0 6.5 5 3 1 6 6 6 2 Leucine-rich repeat LRR_5 PF13306.4 001144866.2_39728001_2 - 4.8e-05 23.2 0.1 0.39 10.5 0.0 3.9 4 1 0 4 4 4 2 Leucine rich repeats (6 copies) FNIP PF05725.10 001144866.2_39728001_2 - 0.48 10.5 16.0 1 9.5 0.8 4.4 3 2 0 3 3 3 0 FNIP Repeat Bcl-2 PF00452.17 001266501.2_29628001_2 - 5.7e-25 87.7 0.1 1.1e-24 86.8 0.1 1.5 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family TNF PF00229.16 001099964.2_37923001_2 - 5.7e-09 35.9 0.0 9.2e-09 35.2 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1q PF00386.19 001142829.1_49822001_1 - 4.5e-39 133.4 0.1 5.5e-39 133.1 0.1 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.16 001142829.1_49822001_1 - 2.9e-17 62.0 60.1 9.8e-10 37.9 33.4 2.3 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) TNF PF00229.16 001285702.1_09022001_3 - 1.1e-09 38.1 0.0 2.1e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family TNF PF00229.16 001105676.1_37923001_1 - 2.2e-10 40.4 0.0 3.6e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family DUF1049 PF06305.9 001105676.1_37923001_1 - 6.4 6.5 8.8 0.073 12.8 1.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) TNF PF00229.16 001097498.1_49823001_1 - 4.1e-10 39.6 0.0 6.6e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1q PF00386.19 001081985.1_37922001_3 - 0.087 12.9 0.1 0.16 12.1 0.1 1.4 1 1 0 1 1 1 0 C1q domain LRR_8 PF13855.4 001130133.2_39729001_2 - 3.6e-68 225.1 99.4 3.9e-10 39.2 1.1 14.5 10 3 3 14 14 14 14 Leucine rich repeat LRR_4 PF12799.5 001130133.2_39729001_2 - 5.7e-30 102.6 109.2 4.1e-06 26.9 6.6 16.0 6 4 10 18 18 18 13 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001130133.2_39729001_2 - 9.1e-13 48.2 28.3 2e-05 24.5 1.6 6.7 3 1 4 7 7 7 5 Leucine rich repeats (6 copies) TIR PF01582.18 001130133.2_39729001_2 - 1.7e-12 47.4 0.2 2.7e-12 46.7 0.2 1.3 1 0 0 1 1 1 1 TIR domain LRR_9 PF14580.4 001130133.2_39729001_2 - 1.2e-10 41.0 40.2 0.0071 15.7 0.3 7.1 4 3 3 7 7 7 6 Leucine-rich repeat LRR_1 PF00560.31 001130133.2_39729001_2 - 1.6e-06 27.6 86.3 0.83 10.2 0.9 20.7 21 5 0 21 21 21 8 Leucine Rich Repeat TIR_2 PF13676.4 001130133.2_39729001_2 - 0.0014 18.8 0.0 0.0024 18.0 0.0 1.4 1 0 0 1 1 1 1 TIR domain LRR_6 PF13516.4 001130133.2_39729001_2 - 0.83 9.7 68.4 0.73 9.9 0.7 16.8 19 0 0 19 19 19 0 Leucine Rich repeat TNF PF00229.16 001130844.1_22422001_1 - 4.1e-46 155.9 0.4 6.8e-46 155.2 0.4 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1q PF00386.19 001130844.1_22422001_1 - 0.065 13.3 1.6 0.77 9.8 0.0 2.3 1 1 1 2 2 2 0 C1q domain LRR_8 PF13855.4 001130472.1_39727001_1 - 8.4e-79 259.1 108.6 2.5e-10 39.9 8.6 14.9 9 5 6 15 15 15 14 Leucine rich repeat LRR_4 PF12799.5 001130472.1_39727001_1 - 1e-39 133.6 110.7 8.4e-06 25.9 0.1 15.1 8 4 8 17 17 17 16 Leucine Rich repeats (2 copies) TIR PF01582.18 001130472.1_39727001_1 - 3.3e-16 59.5 0.6 6.1e-16 58.6 0.6 1.4 1 0 0 1 1 1 1 TIR domain LRR_1 PF00560.31 001130472.1_39727001_1 - 1.1e-13 49.4 94.2 0.76 10.3 0.0 21.6 21 4 1 22 22 22 8 Leucine Rich Repeat LRR_5 PF13306.4 001130472.1_39727001_1 - 1.9e-11 43.9 31.0 0.00093 19.0 0.5 8.3 2 2 3 7 7 7 6 Leucine rich repeats (6 copies) TIR_2 PF13676.4 001130472.1_39727001_1 - 1.6e-06 28.2 0.1 4e-06 27.0 0.1 1.6 1 0 0 1 1 1 1 TIR domain LRR_9 PF14580.4 001130472.1_39727001_1 - 8.1e-05 22.1 46.3 0.052 12.9 0.8 8.6 3 3 6 9 9 9 6 Leucine-rich repeat TNF PF00229.16 001171065.1_22422001_1 - 4.1e-11 42.8 0.0 6.6e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1q PF00386.19 001142830.1_49823001_1 - 7.3e-35 119.8 0.0 9.2e-35 119.5 0.0 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.16 001142830.1_49823001_1 - 6.7e-08 32.0 13.8 1.2e-07 31.3 13.8 1.3 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) TNF PF00229.16 001329086.1_37922001_1 - 3.4e-31 107.7 0.0 4.8e-31 107.2 0.0 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family TNF PF00229.16 001266034.1_29623001_2 - 1.2e-44 151.2 1.0 1.2e-44 151.2 1.0 2.2 2 0 0 2 2 2 1 TNF(Tumour Necrosis Factor) family C1q PF00386.19 001266034.1_29623001_2 - 0.0084 16.2 3.7 0.59 10.2 0.1 2.8 1 1 1 2 2 2 2 C1q domain TNF PF00229.16 001025217.1_49822001_1 - 0.13 12.1 0.2 0.99 9.2 0.1 2.0 1 1 1 2 2 2 0 TNF(Tumour Necrosis Factor) family TNF PF00229.16 001285736.1_09022001_1 - 3.2e-11 43.1 0.0 4.8e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family TNF PF00229.16 001205141.1_32322001_1 - 5.9e-14 52.0 0.0 1.4e-13 50.7 0.0 1.6 2 0 0 2 2 2 1 TNF(Tumour Necrosis Factor) family C1q PF00386.19 001205141.1_32322001_1 - 0.0075 16.4 0.0 0.012 15.7 0.0 1.3 1 0 0 1 1 1 1 C1q domain Porin_2 PF02530.12 001205141.1_32322001_1 - 0.13 11.4 0.1 0.17 11.0 0.1 1.1 1 0 0 1 1 1 0 Porin subfamily Bcl-2 PF00452.17 001283850.1_29525001_2 - 2.8e-25 88.7 0.1 5.4e-25 87.8 0.1 1.5 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family TNF PF00229.16 001329085.1_37922001_1 - 1.6e-45 154.0 1.1 2.9e-45 153.2 1.1 1.4 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1q PF00386.19 001329085.1_37922001_1 - 0.064 13.3 2.4 0.32 11.1 0.1 2.6 2 1 1 3 3 3 0 C1q domain DUF4381 PF14316.4 001329085.1_37922001_1 - 0.07 13.3 0.0 0.21 11.7 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) TNF PF00229.16 001287647.1_29522001_1 - 3.1e-30 104.6 0.0 4.4e-30 104.1 0.0 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1q PF00386.19 001145386.1_49827001_1 - 7.6e-34 116.5 3.3 1.1e-33 116.0 3.3 1.3 1 0 0 1 1 1 1 C1q domain Collagen PF01391.16 001145386.1_49827001_1 - 1.4e-09 37.5 32.1 3.4e-09 36.2 32.0 1.7 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) TNF PF00229.16 001314329.1_09022001_1 - 1.1e-31 109.3 0.0 1.8e-31 108.6 0.0 1.4 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1q PF00386.19 001314329.1_09022001_1 - 0.054 13.6 0.2 0.19 11.8 0.0 1.9 2 0 0 2 2 2 0 C1q domain MHC2-interact PF09307.8 001314329.1_09022001_1 - 0.089 12.7 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 CLIP, MHC2 interacting 7tm_1 PF00001.19 001172758.1_09923001_1 - 1.5e-42 145.6 14.5 1.9e-42 145.3 14.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 001172758.1_09923001_1 - 1.5e-09 37.5 8.2 1.5e-09 37.5 8.2 1.9 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srw PF10324.7 001172758.1_09923001_1 - 7.5e-08 31.9 7.2 7.5e-08 31.9 7.2 2.1 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Sru PF10322.7 001172758.1_09923001_1 - 0.00031 20.0 4.7 0.00031 20.0 4.7 2.0 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Sru 7tm_4 PF13853.4 001172758.1_09923001_1 - 0.00041 20.0 2.4 0.00041 20.0 2.4 2.1 2 0 0 2 2 2 2 Olfactory receptor WBP-1 PF11669.6 001172758.1_09923001_1 - 0.33 11.5 5.2 0.086 13.3 1.6 1.9 2 0 0 2 2 2 0 WW domain-binding protein 1 IL6 PF00489.15 001173536.2_40422001_1 - 1.5e-88 295.1 1.3 1.7e-88 294.9 1.3 1.0 1 0 0 1 1 1 1 Interleukin-6/G-CSF/MGF family GCSF PF16647.3 001173536.2_40422001_1 - 0.023 14.4 0.1 0.029 14.1 0.1 1.2 1 0 0 1 1 1 0 Granulocyte colony-stimulating factor Phage_int_SAM_1 PF02899.15 001173536.2_40422001_1 - 0.08 13.1 1.4 0.13 12.4 1.4 1.3 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain MHC_II_beta PF00969.17 001284566.1_29523001_3 - 3.4e-33 113.5 0.8 5.9e-33 112.7 0.8 1.4 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001284566.1_29523001_3 - 4e-27 94.4 0.2 1.6e-26 92.4 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001284566.1_29523001_3 - 0.00027 21.3 0.1 0.00081 19.8 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001284566.1_29523001_3 - 0.00047 20.1 0.1 0.0011 19.0 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001284566.1_29523001_3 - 0.0035 17.5 0.0 0.0077 16.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 001284566.1_29523001_3 - 0.0043 17.0 0.0 0.011 15.7 0.0 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ODC_AZ PF02100.15 001289676.1_09922001_3 - 3.1e-20 72.1 0.0 4.8e-20 71.5 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001285559.1_09023001_2 - 2.8e-20 72.3 0.0 4.8e-20 71.5 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001289792.1_40423001_3 - 8.2e-20 70.8 0.0 1.4e-19 70.0 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001289918.1_39724001_1 - 7.2e-20 71.0 0.0 1.2e-19 70.2 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001289957.1_09924001_3 - 5.4e-20 71.4 0.0 1.1e-19 70.4 0.0 1.4 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001289996.1_40424001_3 - 7.7e-20 70.9 0.0 1.3e-19 70.2 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001290120.1_09024001_1 - 6.7e-20 71.1 0.0 1.3e-19 70.2 0.0 1.4 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001290281.1_09922001_3 - 1.5e-14 53.8 0.0 2.3e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Cu-oxidase_3 PF07732.13 001290281.1_09922001_3 - 0.0063 16.4 0.2 0.012 15.5 0.0 1.5 2 0 0 2 2 2 1 Multicopper oxidase ODC_AZ PF02100.15 001290344.1_40422001_1 - 5.7e-15 55.2 0.0 8.1e-15 54.7 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Retrotrans_gag PF03732.15 001291007.1_09929001_1 - 1.2e-13 51.0 1.9 1.6e-13 50.6 0.0 2.1 2 0 0 2 2 2 1 Retrotransposon gag protein DUF4939 PF16297.3 001291007.1_09929001_1 - 1.5e-13 50.4 0.1 2.7e-13 49.6 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) zf-CCHC_5 PF14787.4 001291007.1_09929001_1 - 0.0018 17.8 0.2 0.0045 16.5 0.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger DDHD PF02862.15 001291007.1_09929001_1 - 0.065 13.2 6.6 0.11 12.5 6.6 1.2 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.15 001291007.1_09929001_1 - 0.069 11.8 9.2 0.1 11.2 9.2 1.1 1 0 0 1 1 1 0 Presenilin DUF1664 PF07889.10 001291007.1_09929001_1 - 0.15 12.0 1.3 0.31 10.9 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) zf-CCHC PF00098.21 001291007.1_09929001_1 - 0.15 12.1 2.2 0.35 10.9 2.2 1.7 1 0 0 1 1 1 0 Zinc knuckle CDC27 PF09507.8 001291007.1_09929001_1 - 0.19 10.9 17.0 0.3 10.3 17.0 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RRN3 PF05327.9 001291007.1_09929001_1 - 0.42 9.0 10.7 0.6 8.5 10.7 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SDA1 PF05285.10 001291007.1_09929001_1 - 0.46 9.8 21.7 0.68 9.2 21.7 1.1 1 0 0 1 1 1 0 SDA1 DUF4407 PF14362.4 001291007.1_09929001_1 - 5.3 6.2 12.1 8.2 5.5 12.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) EIIBC-GUT_N PF03612.12 001291007.1_09929001_1 - 6.4 6.3 7.6 11 5.5 7.6 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Paf1 PF03985.11 001291007.1_09929001_1 - 6.4 5.5 29.6 9.3 5.0 29.6 1.2 1 0 0 1 1 1 0 Paf1 DUF913 PF06025.10 001291007.1_09929001_1 - 7.7 5.2 9.7 12 4.6 9.7 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Nop14 PF04147.10 001291007.1_09929001_1 - 8.6 4.3 28.6 12 3.8 28.6 1.1 1 0 0 1 1 1 0 Nop14-like family Asp_protease_2 PF13650.4 001291007.1_09929001_3 - 0.004 17.7 0.0 0.0069 16.9 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001291007.1_09929001_3 - 0.031 14.1 0.0 0.055 13.3 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001291007.1_09929001_3 - 0.19 12.2 0.0 0.31 11.5 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.4 001291072.1_40429001_2 - 0.00079 19.9 0.0 0.0013 19.3 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001291072.1_40429001_2 - 0.016 15.0 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001291072.1_40429001_2 - 0.053 14.0 0.0 0.086 13.3 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Retrotrans_gag PF03732.15 001291072.1_40429001_3 - 4.8e-15 55.5 1.9 1.9e-14 53.6 0.0 2.4 2 0 0 2 2 2 1 Retrotransposon gag protein DUF4939 PF16297.3 001291072.1_40429001_3 - 5.1e-15 55.2 0.0 9.4e-15 54.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Rootletin PF15035.4 001291072.1_40429001_3 - 0.00034 20.6 0.1 0.00067 19.7 0.1 1.4 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion KASH_CCD PF14662.4 001291072.1_40429001_3 - 0.0021 17.8 4.6 0.0035 17.1 4.6 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH zf-CCHC_5 PF14787.4 001291072.1_40429001_3 - 0.0029 17.1 0.2 0.0069 15.9 0.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger Spc29 PF17082.3 001291072.1_40429001_3 - 0.0078 15.9 0.5 0.013 15.2 0.5 1.2 1 0 0 1 1 1 1 Spindle Pole Component 29 SlyX PF04102.10 001291072.1_40429001_3 - 0.3 11.6 2.4 0.71 10.4 2.4 1.7 1 0 0 1 1 1 0 SlyX CENP-H PF05837.10 001291072.1_40429001_3 - 0.41 10.9 4.7 0.85 9.9 4.7 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) ZapB PF06005.10 001291072.1_40429001_3 - 0.59 10.5 9.7 1.4 9.3 9.7 1.6 1 0 0 1 1 1 0 Cell division protein ZapB CCDC106 PF15794.3 001291072.1_40429001_3 - 0.67 9.5 3.6 0.86 9.1 2.3 1.7 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 DUF972 PF06156.11 001291072.1_40429001_3 - 0.76 10.3 3.9 2 9.0 3.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF972) IncA PF04156.12 001291072.1_40429001_3 - 1.1 8.8 3.4 2.3 7.8 3.4 1.4 1 0 0 1 1 1 0 IncA protein DivIC PF04977.13 001291072.1_40429001_3 - 3.6 7.3 7.1 8.7 6.1 7.1 1.6 1 0 0 1 1 1 0 Septum formation initiator SHE3 PF17078.3 001291072.1_40429001_3 - 8.2 5.9 10.2 2.2 7.8 7.1 1.5 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 ODC_AZ PF02100.15 001291427.1_32323001_3 - 9e-21 73.9 0.0 1.8e-20 72.9 0.0 1.4 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001291435.1_32324001_2 - 5.8e-20 71.3 0.0 1.1e-19 70.4 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001291460.1_01324001_3 - 5.3e-20 71.4 0.0 1e-19 70.5 0.0 1.4 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001291461.1_01322001_3 - 2.4e-14 53.1 0.0 3.6e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001291912.1_37924001_2 - 5.1e-20 71.4 0.0 1e-19 70.5 0.0 1.4 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001291917.1_29524001_1 - 7.7e-20 70.9 0.0 1.3e-19 70.1 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001291987.1_37922001_3 - 2.3e-15 56.5 0.0 3.2e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001289795.2_39523001_1 - 2.1e-20 72.7 0.0 3.8e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001301326.1_49823001_3 - 2.2e-20 72.7 0.0 4.5e-20 71.6 0.0 1.5 2 0 0 2 2 2 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001290006.2_39523001_3 - 4.3e-20 71.7 0.0 8.8e-20 70.7 0.0 1.4 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001172571.2_39722001_1 - 5e-15 55.4 0.0 7.6e-15 54.8 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001301406.1_49822001_1 - 8.9e-16 57.8 0.0 1.3e-15 57.3 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001301411.1_43522001_3 - 6.7e-15 55.0 0.0 1e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme DUF5087 PF17006.3 001291436.1_32322001_2 - 0.066 12.6 0.3 0.086 12.2 0.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF5087) ODC_AZ PF02100.15 001291436.1_32322001_3 - 7.1e-15 54.9 0.0 1.1e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001301417.1_40422001_3 - 4.5e-15 55.5 0.0 6.8e-15 54.9 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Asp_protease_2 PF13650.4 001172426.3_39729001_2 - 0.00076 20.0 0.0 0.0013 19.3 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001172426.3_39729001_2 - 0.016 15.1 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001172426.3_39729001_2 - 0.052 14.0 0.0 0.085 13.3 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DUF4939 PF16297.3 001172426.3_39729001_3 - 5.4e-15 55.1 0.0 9.9e-15 54.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Retrotrans_gag PF03732.15 001172426.3_39729001_3 - 1.2e-14 54.2 1.9 5e-14 52.2 0.0 2.3 2 0 0 2 2 2 1 Retrotransposon gag protein Rootletin PF15035.4 001172426.3_39729001_3 - 0.00043 20.3 0.1 0.00081 19.4 0.1 1.3 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion KASH_CCD PF14662.4 001172426.3_39729001_3 - 0.002 17.9 4.7 0.0032 17.2 4.7 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH zf-CCHC_5 PF14787.4 001172426.3_39729001_3 - 0.0028 17.2 0.2 0.0064 16.0 0.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger Spc29 PF17082.3 001172426.3_39729001_3 - 0.0069 16.1 0.4 0.011 15.4 0.4 1.2 1 0 0 1 1 1 1 Spindle Pole Component 29 CENP-H PF05837.10 001172426.3_39729001_3 - 0.24 11.7 4.8 0.47 10.8 4.8 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) ZapB PF06005.10 001172426.3_39729001_3 - 0.33 11.3 9.2 0.67 10.3 9.2 1.4 1 0 0 1 1 1 0 Cell division protein ZapB DUF972 PF06156.11 001172426.3_39729001_3 - 0.33 11.5 3.8 0.79 10.3 3.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Spc7 PF08317.9 001172426.3_39729001_3 - 0.37 9.5 3.4 0.65 8.7 3.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF5082 PF16888.3 001172426.3_39729001_3 - 0.38 11.0 3.9 0.68 10.2 2.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) LPP PF04728.11 001172426.3_39729001_3 - 0.62 10.4 2.1 1.3 9.4 2.1 1.5 1 0 0 1 1 1 0 Lipoprotein leucine-zipper SHE3 PF17078.3 001172426.3_39729001_3 - 0.79 9.3 7.3 1.6 8.3 7.3 1.4 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 DivIC PF04977.13 001172426.3_39729001_3 - 1.2 8.8 5.9 2.3 7.9 5.9 1.4 1 0 0 1 1 1 0 Septum formation initiator bZIP_1 PF00170.19 001172426.3_39729001_3 - 1.5 8.8 8.4 3.3 7.8 8.4 1.5 1 0 0 1 1 1 0 bZIP transcription factor IncA PF04156.12 001172426.3_39729001_3 - 1.7 8.3 5.3 3.3 7.3 5.3 1.4 1 0 0 1 1 1 0 IncA protein TSC22 PF01166.16 001172426.3_39729001_3 - 6.9 6.9 7.5 39 4.5 7.5 2.1 1 1 0 1 1 1 0 TSC-22/dip/bun family Asp_protease_2 PF13650.4 001302444.1_39729001_1 - 0.00076 20.0 0.0 0.0013 19.3 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001302444.1_39729001_1 - 0.016 15.1 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001302444.1_39729001_1 - 0.052 14.0 0.0 0.085 13.3 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DUF4939 PF16297.3 001302444.1_39729001_2 - 5.4e-15 55.1 0.0 9.9e-15 54.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Retrotrans_gag PF03732.15 001302444.1_39729001_2 - 1.3e-14 54.1 1.9 5e-14 52.2 0.0 2.2 2 0 0 2 2 2 1 Retrotransposon gag protein Rootletin PF15035.4 001302444.1_39729001_2 - 0.00037 20.5 0.1 0.00065 19.7 0.1 1.3 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion KASH_CCD PF14662.4 001302444.1_39729001_2 - 0.002 17.9 4.7 0.0032 17.2 4.7 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH zf-CCHC_5 PF14787.4 001302444.1_39729001_2 - 0.0027 17.2 0.2 0.0064 16.0 0.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger Spc29 PF17082.3 001302444.1_39729001_2 - 0.0068 16.2 0.4 0.011 15.5 0.4 1.2 1 0 0 1 1 1 1 Spindle Pole Component 29 CCDC106 PF15794.3 001302444.1_39729001_2 - 0.14 11.7 3.8 0.55 9.8 2.2 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 CENP-H PF05837.10 001302444.1_39729001_2 - 0.24 11.7 4.8 0.47 10.8 4.8 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) ZapB PF06005.10 001302444.1_39729001_2 - 0.33 11.3 9.2 0.67 10.3 9.2 1.4 1 0 0 1 1 1 0 Cell division protein ZapB DUF972 PF06156.11 001302444.1_39729001_2 - 0.33 11.4 3.8 0.79 10.3 3.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Spc7 PF08317.9 001302444.1_39729001_2 - 0.37 9.5 3.4 0.65 8.7 3.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF5082 PF16888.3 001302444.1_39729001_2 - 0.38 11.0 3.9 0.68 10.2 2.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) LPP PF04728.11 001302444.1_39729001_2 - 0.62 10.4 2.1 1.3 9.4 2.1 1.5 1 0 0 1 1 1 0 Lipoprotein leucine-zipper SHE3 PF17078.3 001302444.1_39729001_2 - 0.79 9.3 7.3 1.6 8.3 7.3 1.4 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 DivIC PF04977.13 001302444.1_39729001_2 - 1.2 8.8 5.9 2.3 7.9 5.9 1.4 1 0 0 1 1 1 0 Septum formation initiator bZIP_1 PF00170.19 001302444.1_39729001_2 - 1.5 8.8 8.4 3.3 7.8 8.4 1.5 1 0 0 1 1 1 0 bZIP transcription factor IncA PF04156.12 001302444.1_39729001_2 - 1.6 8.3 5.3 3.2 7.4 5.3 1.4 1 0 0 1 1 1 0 IncA protein TSC22 PF01166.16 001302444.1_39729001_2 - 7 6.9 7.5 39 4.5 7.5 2.1 1 1 0 1 1 1 0 TSC-22/dip/bun family Asp_protease_2 PF13650.4 001292089.2_37929001_1 - 0.001 19.5 0.1 0.0025 18.3 0.0 1.6 2 0 0 2 2 2 1 Aspartyl protease RVP_2 PF08284.9 001292089.2_37929001_1 - 0.019 14.9 0.0 0.039 13.8 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001292089.2_37929001_1 - 0.044 14.2 0.0 0.08 13.4 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DUF4939 PF16297.3 001292089.2_37929001_2 - 1.8e-15 56.6 0.0 3.3e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Retrotrans_gag PF03732.15 001292089.2_37929001_2 - 2.9e-15 56.2 2.2 7.3e-15 54.9 0.1 2.3 2 0 0 2 2 2 1 Retrotransposon gag protein zf-CCHC_5 PF14787.4 001292089.2_37929001_2 - 0.0026 17.3 0.2 0.0063 16.1 0.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger KASH_CCD PF14662.4 001292089.2_37929001_2 - 0.004 16.9 4.9 0.0066 16.2 4.9 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH IncA PF04156.12 001292089.2_37929001_2 - 0.035 13.7 4.7 0.09 12.4 4.7 1.6 1 0 0 1 1 1 0 IncA protein Spc29 PF17082.3 001292089.2_37929001_2 - 0.04 13.6 0.4 0.069 12.9 0.4 1.2 1 0 0 1 1 1 0 Spindle Pole Component 29 SlyX PF04102.10 001292089.2_37929001_2 - 0.045 14.2 3.1 0.15 12.6 3.1 1.9 1 0 0 1 1 1 0 SlyX CCDC106 PF15794.3 001292089.2_37929001_2 - 0.049 13.2 0.6 0.094 12.3 0.6 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 CASP_C PF08172.10 001292089.2_37929001_2 - 0.061 12.5 0.1 0.42 9.8 0.0 1.9 2 0 0 2 2 2 0 CASP C terminal ZapB PF06005.10 001292089.2_37929001_2 - 0.26 11.6 10.8 0.59 10.5 10.8 1.5 1 0 0 1 1 1 0 Cell division protein ZapB Rootletin PF15035.4 001292089.2_37929001_2 - 0.46 10.4 9.3 0.81 9.6 9.3 1.3 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF972 PF06156.11 001292089.2_37929001_2 - 0.66 10.5 3.9 1.6 9.3 3.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) GIT_CC PF16559.3 001292089.2_37929001_2 - 0.95 9.4 6.2 2.6 8.0 6.2 1.7 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Uso1_p115_C PF04871.11 001292089.2_37929001_2 - 0.99 9.7 9.4 1.6 8.9 9.4 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region CENP-H PF05837.10 001292089.2_37929001_2 - 1.1 9.6 7.8 2.2 8.6 7.8 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) ERM PF00769.17 001292089.2_37929001_2 - 1.4 8.5 11.8 2.5 7.7 11.8 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DivIC PF04977.13 001292089.2_37929001_2 - 1.6 8.4 6.5 3.8 7.2 6.5 1.6 1 0 0 1 1 1 0 Septum formation initiator TBPIP PF07106.11 001292089.2_37929001_2 - 2.4 7.8 7.2 1 9.0 4.7 1.5 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TSC22 PF01166.16 001292089.2_37929001_2 - 8.4 6.7 6.2 45 4.3 6.2 2.0 1 1 0 1 1 1 0 TSC-22/dip/bun family DUF4939 PF16297.3 001302483.1_37929001_1 - 1.8e-15 56.6 0.0 3.3e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Retrotrans_gag PF03732.15 001302483.1_37929001_1 - 2.9e-15 56.2 2.2 7.3e-15 54.9 0.1 2.3 2 0 0 2 2 2 1 Retrotransposon gag protein zf-CCHC_5 PF14787.4 001302483.1_37929001_1 - 0.0025 17.3 0.2 0.0063 16.1 0.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger KASH_CCD PF14662.4 001302483.1_37929001_1 - 0.004 16.9 4.9 0.0067 16.2 4.9 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH Spc29 PF17082.3 001302483.1_37929001_1 - 0.04 13.6 0.4 0.069 12.9 0.4 1.2 1 0 0 1 1 1 0 Spindle Pole Component 29 SlyX PF04102.10 001302483.1_37929001_1 - 0.047 14.2 3.1 0.15 12.6 3.1 1.8 1 0 0 1 1 1 0 SlyX CCDC106 PF15794.3 001302483.1_37929001_1 - 0.048 13.2 0.6 0.094 12.3 0.6 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 CASP_C PF08172.10 001302483.1_37929001_1 - 0.06 12.5 0.1 0.41 9.8 0.0 1.9 2 0 0 2 2 2 0 CASP C terminal IncA PF04156.12 001302483.1_37929001_1 - 0.12 12.1 6.4 0.29 10.8 6.4 1.6 1 0 0 1 1 1 0 IncA protein ZapB PF06005.10 001302483.1_37929001_1 - 0.26 11.6 10.8 0.6 10.5 10.8 1.5 1 0 0 1 1 1 0 Cell division protein ZapB Rootletin PF15035.4 001302483.1_37929001_1 - 0.45 10.4 9.3 0.81 9.6 9.3 1.3 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF972 PF06156.11 001302483.1_37929001_1 - 0.66 10.5 3.9 1.6 9.3 3.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) GIT_CC PF16559.3 001302483.1_37929001_1 - 0.95 9.4 6.2 2.6 8.0 6.2 1.7 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Uso1_p115_C PF04871.11 001302483.1_37929001_1 - 0.99 9.7 9.4 1.6 8.9 9.4 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region CENP-H PF05837.10 001302483.1_37929001_1 - 1.1 9.6 7.8 2.2 8.6 7.8 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) ERM PF00769.17 001302483.1_37929001_1 - 1.4 8.5 11.8 2.5 7.7 11.8 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DivIC PF04977.13 001302483.1_37929001_1 - 1.6 8.4 6.5 3.8 7.2 6.5 1.6 1 0 0 1 1 1 0 Septum formation initiator TBPIP PF07106.11 001302483.1_37929001_1 - 2.4 7.8 7.2 1 9.0 4.7 1.5 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TSC22 PF01166.16 001302483.1_37929001_1 - 8.5 6.6 6.2 45 4.3 6.2 2.0 1 1 0 1 1 1 0 TSC-22/dip/bun family Asp_protease_2 PF13650.4 001302483.1_37929001_3 - 0.0011 19.5 0.1 0.0025 18.3 0.0 1.6 2 0 0 2 2 2 1 Aspartyl protease RVP_2 PF08284.9 001302483.1_37929001_3 - 0.019 14.8 0.0 0.039 13.8 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001302483.1_37929001_3 - 0.044 14.2 0.0 0.081 13.4 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease ODC_AZ PF02100.15 001305001.1_37922001_1 - 2.5e-20 72.4 0.0 3.9e-20 71.8 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001290359.1_39522001_1 - 4.9e-15 55.4 0.0 6.9e-15 54.9 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001301418.1_39522001_3 - 5e-15 55.4 0.0 7.4e-15 54.8 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001290005.1_22424001_2 - 6.8e-20 71.0 0.0 1.3e-19 70.2 0.0 1.4 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Retrotrans_gag PF03732.15 001291089.1_22426001_1 - 2.7e-16 59.5 2.4 3.7e-15 55.8 0.1 2.4 2 0 0 2 2 2 1 Retrotransposon gag protein DUF4939 PF16297.3 001291089.1_22426001_1 - 2.2e-15 56.3 0.0 4e-15 55.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Rootletin PF15035.4 001291089.1_22426001_1 - 8.9e-05 22.5 1.1 0.00018 21.5 1.1 1.4 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion KASH_CCD PF14662.4 001291089.1_22426001_1 - 0.00013 21.7 2.9 0.00023 20.9 2.9 1.3 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH CASP_C PF08172.10 001291089.1_22426001_1 - 0.00099 18.4 0.0 0.0015 17.8 0.0 1.2 1 0 0 1 1 1 1 CASP C terminal zf-CCHC_5 PF14787.4 001291089.1_22426001_1 - 0.0018 17.8 0.2 0.0018 17.8 0.2 1.9 2 0 0 2 2 1 1 GAG-polyprotein viral zinc-finger SR-25 PF10500.7 001291089.1_22426001_1 - 0.0049 16.4 5.8 0.0049 16.4 5.8 2.1 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Uso1_p115_C PF04871.11 001291089.1_22426001_1 - 0.029 14.6 2.7 0.049 13.9 2.7 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Spc7 PF08317.9 001291089.1_22426001_1 - 0.039 12.7 3.3 0.079 11.7 3.3 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein zf-CCHC PF00098.21 001291089.1_22426001_1 - 0.044 13.7 2.2 0.13 12.2 2.2 1.9 1 0 0 1 1 1 0 Zinc knuckle ZapB PF06005.10 001291089.1_22426001_1 - 0.059 13.7 8.3 0.17 12.3 8.3 1.7 1 0 0 1 1 1 0 Cell division protein ZapB DUF972 PF06156.11 001291089.1_22426001_1 - 0.064 13.8 2.9 0.19 12.2 2.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF972) SHE3 PF17078.3 001291089.1_22426001_1 - 0.082 12.5 6.0 0.036 13.6 3.4 1.6 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 CENP-H PF05837.10 001291089.1_22426001_1 - 0.1 12.9 5.5 0.29 11.4 5.5 1.7 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF1664 PF07889.10 001291089.1_22426001_1 - 0.1 12.4 0.4 0.23 11.3 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) V_ATPase_I PF01496.17 001291089.1_22426001_1 - 0.12 10.1 0.4 0.16 9.7 0.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family IncA PF04156.12 001291089.1_22426001_1 - 0.16 11.6 6.7 0.3 10.7 6.7 1.4 1 0 0 1 1 1 0 IncA protein TolA_bind_tri PF16331.3 001291089.1_22426001_1 - 0.17 11.9 4.9 0.36 10.8 4.9 1.5 1 0 0 1 1 1 0 TolA binding protein trimerisation eIF3g PF12353.6 001291089.1_22426001_1 - 0.2 11.9 0.1 0.2 11.9 0.1 1.7 2 0 0 2 2 1 0 Eukaryotic translation initiation factor 3 subunit G TMF_DNA_bd PF12329.6 001291089.1_22426001_1 - 0.24 11.3 6.5 0.47 10.4 6.5 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF3450 PF11932.6 001291089.1_22426001_1 - 0.25 10.5 3.8 0.45 9.6 3.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Prominin PF05478.9 001291089.1_22426001_1 - 0.38 8.5 0.8 0.6 7.9 0.8 1.1 1 0 0 1 1 1 0 Prominin SlyX PF04102.10 001291089.1_22426001_1 - 0.7 10.4 5.6 2.5 8.7 5.6 1.9 1 0 0 1 1 1 0 SlyX FlxA PF14282.4 001291089.1_22426001_1 - 1.1 9.1 8.8 3.4 7.6 8.7 1.7 1 1 0 1 1 1 0 FlxA-like protein GIT_CC PF16559.3 001291089.1_22426001_1 - 1.6 8.7 8.6 5.3 7.0 8.6 1.8 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor RCDG1 PF15725.3 001291089.1_22426001_1 - 3 8.2 11.7 9.6 6.6 11.7 1.9 1 0 0 1 1 1 0 Renal cancer differentiation gene 1 protein APG6 PF04111.10 001291089.1_22426001_1 - 3.7 6.7 6.2 1.2 8.3 3.3 1.5 2 0 0 2 2 2 0 Autophagy protein Apg6 TSC22 PF01166.16 001291089.1_22426001_1 - 4.9 7.4 7.5 31 4.9 7.5 2.0 1 1 0 1 1 1 0 TSC-22/dip/bun family HALZ PF02183.16 001291089.1_22426001_1 - 5.6 7.1 5.9 11 6.2 3.8 2.2 1 1 1 2 2 2 0 Homeobox associated leucine zipper XhlA PF10779.7 001291089.1_22426001_1 - 9.4 6.4 6.2 17 5.5 6.2 1.4 1 0 0 1 1 1 0 Haemolysin XhlA Asp_protease_2 PF13650.4 001291089.1_22426001_3 - 0.00015 22.2 0.0 0.00025 21.5 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001291089.1_22426001_3 - 0.0037 17.1 0.0 0.0062 16.4 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001291089.1_22426001_3 - 0.016 15.6 0.0 0.027 14.9 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease ODC_AZ PF02100.15 001290358.1_22422001_3 - 1.2e-13 50.9 0.0 1.8e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001127368.3_39723001_3 - 8.5e-20 70.7 0.0 1.4e-19 70.0 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme RAG1 PF12940.5 001266772.1_29628001_1 - 0 1271.9 0.8 0 1271.9 0.8 1.4 2 0 0 2 2 2 1 Recombination-activation protein 1 (RAG1), recombinase RAG1_imp_bd PF12560.6 001266772.1_29628001_1 - 1e-121 405.8 13.0 2.1e-121 404.8 13.0 1.5 1 0 0 1 1 1 1 RAG1 importin binding zf-RAG1 PF10426.7 001266772.1_29628001_1 - 6.5e-18 64.4 11.2 9.5e-17 60.7 4.3 2.5 2 0 0 2 2 2 2 Recombination-activating protein 1 zinc-finger domain zf-C3HC4 PF00097.23 001266772.1_29628001_1 - 6.1e-06 25.9 13.8 6.1e-06 25.9 13.8 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001266772.1_29628001_1 - 1.1e-05 25.0 12.7 1.1e-05 25.0 12.7 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 001266772.1_29628001_1 - 0.0022 17.7 8.1 0.0022 17.7 8.1 2.2 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_2 PF13639.4 001266772.1_29628001_1 - 0.0035 17.4 12.9 0.0035 17.4 12.9 3.8 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_4 PF15227.4 001266772.1_29628001_1 - 0.0078 16.2 13.6 0.0078 16.2 13.6 3.2 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.3 001266772.1_29628001_1 - 0.01 15.8 10.7 0.01 15.8 10.7 3.5 4 0 0 4 4 3 0 zinc RING finger of MSL2 zf-RING_UBOX PF13445.4 001266772.1_29628001_1 - 1.5 8.8 17.6 0.035 14.0 9.5 2.6 3 0 0 3 3 3 0 RING-type zinc-finger zf-Nse PF11789.6 001266772.1_29628001_1 - 8.4 6.2 12.3 38 4.1 12.3 2.2 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit RAG1 PF12940.5 001242754.1_37627001_1 - 0 1259.1 0.7 0 1258.3 0.7 1.3 1 0 0 1 1 1 1 Recombination-activation protein 1 (RAG1), recombinase RAG1_imp_bd PF12560.6 001242754.1_37627001_1 - 7.1e-104 347.2 10.4 7.1e-104 347.2 10.4 2.5 3 0 0 3 3 3 1 RAG1 importin binding zf-RAG1 PF10426.7 001242754.1_37627001_1 - 4.7e-18 64.9 10.5 8.8e-17 60.8 3.7 2.6 2 0 0 2 2 2 2 Recombination-activating protein 1 zinc-finger domain zf-C3HC4_2 PF13923.4 001242754.1_37627001_1 - 1.8e-06 27.5 15.0 1.8e-06 27.5 15.0 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001242754.1_37627001_1 - 2.7e-06 27.0 16.1 2.7e-06 27.0 16.1 3.2 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 001242754.1_37627001_1 - 0.00018 21.2 8.5 0.00018 21.2 8.5 2.3 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.4 001242754.1_37627001_1 - 0.0016 18.4 13.7 0.0016 18.4 13.7 3.2 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 001242754.1_37627001_1 - 0.004 17.0 14.2 0.004 17.0 14.2 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.4 001242754.1_37627001_1 - 0.0052 16.9 15.3 0.0052 16.9 15.3 3.4 3 0 0 3 3 1 1 Ring finger domain U-box PF04564.13 001242754.1_37627001_1 - 0.14 12.2 0.2 3.7 7.7 0.0 2.6 2 0 0 2 2 2 0 U-box domain zf-Nse PF11789.6 001242754.1_37627001_1 - 4 7.2 13.8 17 5.2 13.8 2.1 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Lectin_C PF00059.19 001302493.1_26221001_3 - 3.1e-08 34.2 0.2 4.1e-08 33.8 0.2 1.1 1 0 0 1 1 1 1 Lectin C-type domain LIF_OSM PF01291.15 001245923.1_37922001_1 - 7.3e-64 214.7 0.2 8.5e-64 214.4 0.2 1.0 1 0 0 1 1 1 1 LIF / OSM family PX PF00787.22 146145.1_26225120_3 - 3.5e-13 49.4 1.3 7e-13 48.4 1.3 1.4 1 0 0 1 1 1 1 PX domain ATG7_N PF16420.3 110628.1_26225120_1 - 0.06 12.9 0.1 0.083 12.4 0.1 1.1 1 0 0 1 1 1 0 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus Chol_subst-bind PF09129.9 110208.1_26222120_3 - 0.07 11.9 0.2 0.26 10.1 0.1 1.7 2 0 0 2 2 2 0 Cholesterol oxidase, substrate-binding PAN_4 PF14295.4 120685.1_26222120_3 - 0.026 14.3 1.0 0.056 13.2 1.0 1.6 1 0 0 1 1 1 0 PAN domain DUF4591 PF15261.4 126535.1_32921120_3 - 0.012 16.2 0.6 0.015 15.8 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4591) PROCT PF08084.9 135090.1_26222120_3 - 0.041 13.7 0.0 0.063 13.1 0.0 1.3 1 0 0 1 1 1 0 PROCT (NUC072) domain CC2D2AN-C2 PF15625.4 001349481.1_37929001_3 - 1.1e-49 168.3 0.1 2.3e-49 167.2 0.1 1.6 1 0 0 1 1 1 1 CC2D2A N-terminal C2 domain zf-C3HC4_4 PF15227.4 001163659.1_22423001_1 - 5.3e-13 48.8 7.2 1.5e-12 47.3 7.2 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 001163659.1_22423001_1 - 8.4e-11 41.6 7.7 2.4e-10 40.1 7.7 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001163659.1_22423001_1 - 2.3e-09 36.8 7.3 5.7e-09 35.6 7.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001163659.1_22423001_1 - 3.4e-09 36.6 3.0 3.4e-09 36.6 3.0 3.0 3 1 0 3 3 3 1 B-box zinc finger zf-RING_2 PF13639.4 001163659.1_22423001_1 - 2.4e-08 33.9 6.6 2.4e-08 33.9 6.6 1.9 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.4 001163659.1_22423001_1 - 8.9e-08 31.7 10.0 3.4e-07 29.9 9.2 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001163659.1_22423001_1 - 1.5e-05 24.7 9.2 1.5e-05 24.7 9.2 2.6 2 1 1 3 3 3 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 001163659.1_22423001_1 - 1.7e-05 24.4 8.3 1.7e-05 24.4 8.3 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Cullin_Nedd8 PF10557.7 001163659.1_22423001_1 - 0.022 14.7 0.8 0.16 11.9 0.1 2.3 2 0 0 2 2 2 0 Cullin protein neddylation domain zf-Nse PF11789.6 001163659.1_22423001_1 - 0.027 14.1 5.7 0.069 12.9 5.7 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.4 001163659.1_22423001_1 - 0.088 12.6 7.0 0.26 11.1 7.0 1.8 1 1 0 1 1 1 0 zf-RING of BARD1-type protein Latarcin PF10279.7 001163659.1_22423001_1 - 4.2 7.7 8.8 2.8 8.3 5.2 2.4 1 1 1 2 2 2 0 Latarcin precursor Prok-RING_4 PF14447.4 001163659.1_22423001_1 - 4.8 7.0 19.5 1.3 8.8 11.6 3.1 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 Exonuc_VII_L PF02601.13 001163659.1_22423001_1 - 6.4 6.1 7.9 9.4 5.6 7.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit RINGv PF12906.5 001007759.1_45724001_2 - 6.8e-15 54.8 9.8 1.6e-14 53.6 9.8 1.7 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.4 001007759.1_45724001_2 - 0.0036 17.4 9.9 0.013 15.6 9.9 2.1 1 0 0 1 1 1 1 Ring finger domain Baculo_IE-1 PF05290.9 001007759.1_45724001_2 - 0.035 13.9 0.6 0.065 13.1 0.6 1.3 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Vpu PF00558.17 001007759.1_45724001_2 - 0.18 11.5 0.2 0.35 10.6 0.2 1.4 1 0 0 1 1 1 0 Vpu protein zf-C3HC4 PF00097.23 001007759.1_45724001_2 - 0.49 10.2 5.8 2 8.3 5.8 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) UPAR_LY6 PF00021.19 001261705.1_29624001_2 - 0.18 12.4 14.9 0.13 12.9 12.6 2.0 2 0 0 2 2 2 0 u-PAR/Ly-6 domain DUF2214 PF09980.7 001261705.1_29624001_3 - 0.02 14.6 0.7 0.032 13.9 0.7 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2214) zf-RING_2 PF13639.4 001198705.1_29623001_3 - 1.2e-12 47.8 8.9 1.2e-12 47.8 8.9 2.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.4 001198705.1_29623001_3 - 1.7e-07 30.8 8.1 3.8e-07 29.7 8.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001198705.1_29623001_3 - 9.1e-07 28.5 8.6 2.1e-06 27.3 8.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 001198705.1_29623001_3 - 9.5e-07 28.3 7.5 9.5e-07 28.3 7.5 2.1 2 0 0 2 2 1 1 RING-like zinc finger zf-RING_5 PF14634.4 001198705.1_29623001_3 - 9.9e-07 28.5 10.4 2e-06 27.5 10.4 1.6 1 0 0 1 1 1 1 zinc-RING finger domain PA PF02225.20 001198705.1_29623001_3 - 1.3e-06 28.3 0.0 2.6e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 PA domain zf-rbx1 PF12678.5 001198705.1_29623001_3 - 2.2e-06 27.7 8.8 7.3e-06 26.0 8.8 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.4 001198705.1_29623001_3 - 0.00012 21.9 3.4 0.00012 21.9 3.4 2.6 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 001198705.1_29623001_3 - 0.00017 21.3 7.1 0.00031 20.4 7.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 001198705.1_29623001_3 - 0.0028 17.4 10.2 0.0055 16.4 10.2 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.5 001198705.1_29623001_3 - 0.01 15.7 4.3 0.034 14.0 4.3 1.9 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.3 001198705.1_29623001_3 - 0.39 10.2 6.5 0.84 9.2 6.5 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zinc_ribbon_16 PF17034.3 001198705.1_29623001_3 - 0.45 10.6 4.5 0.26 11.4 2.2 1.7 2 0 0 2 2 1 0 Zinc-ribbon like family PHD PF00628.27 001198705.1_29623001_3 - 3.2 7.6 8.8 8.8 6.2 8.8 1.8 1 0 0 1 1 1 0 PHD-finger RINGv PF12906.5 001198705.1_29623001_3 - 4.7 7.3 10.6 0.86 9.7 6.3 2.0 2 0 0 2 2 2 0 RING-variant domain Prok-RING_1 PF14446.4 001198705.1_29623001_3 - 6.8 6.6 9.1 33 4.4 9.1 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 Zf_RING PF16744.3 001198705.1_29623001_3 - 8.2 6.5 7.8 3 7.9 3.6 2.4 2 1 0 2 2 2 0 KIAA1045 RING finger RINGv PF12906.5 001244915.1_49823001_3 - 1.5e-14 53.7 4.1 1.5e-14 53.7 4.1 2.2 2 0 0 2 2 2 1 RING-variant domain Vpu PF00558.17 001244915.1_49823001_3 - 0.0079 15.8 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Vpu protein zf-RING_2 PF13639.4 001244915.1_49823001_3 - 1.1 9.5 11.0 0.071 13.3 4.0 2.7 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4_4 PF15227.4 001105673.1_37923001_1 - 1.1e-10 41.3 9.4 1.1e-10 41.3 9.4 2.1 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING SPRY PF00622.26 001105673.1_37923001_1 - 1.7e-10 40.9 0.2 6.3e-10 39.1 0.1 2.0 2 0 0 2 2 2 1 SPRY domain zf-RING_UBOX PF13445.4 001105673.1_37923001_1 - 3.2e-10 39.7 5.3 3.2e-10 39.7 5.3 2.7 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001105673.1_37923001_1 - 6.3e-10 38.6 8.0 1.8e-09 37.2 8.0 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001105673.1_37923001_1 - 3.2e-08 33.2 7.4 1.1e-07 31.5 7.4 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001105673.1_37923001_1 - 1e-07 31.8 4.4 1e-07 31.8 4.4 3.1 3 1 0 3 3 2 1 B-box zinc finger zf-RING_2 PF13639.4 001105673.1_37923001_1 - 3.2e-07 30.4 7.1 3.2e-07 30.4 7.1 1.9 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.4 001105673.1_37923001_1 - 1.2e-06 28.1 5.4 1.2e-06 28.1 5.4 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001105673.1_37923001_1 - 2.1e-05 24.3 6.7 2.1e-05 24.3 6.7 2.4 2 1 1 3 3 2 1 zinc-RING finger domain zf-RING_10 PF16685.3 001105673.1_37923001_1 - 0.00016 21.6 3.2 0.00016 21.6 3.2 2.1 2 0 0 2 2 2 1 zinc RING finger of MSL2 zf-Nse PF11789.6 001105673.1_37923001_1 - 0.0015 18.2 4.4 0.0049 16.5 4.4 1.9 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.4 001105673.1_37923001_1 - 0.0019 17.9 2.5 0.0052 16.5 2.5 1.8 1 1 0 1 1 1 1 zf-RING of BARD1-type protein U-box PF04564.13 001105673.1_37923001_1 - 0.031 14.3 0.2 0.1 12.6 0.0 1.9 2 0 0 2 2 1 0 U-box domain Apolipoprotein PF01442.16 001105673.1_37923001_1 - 0.036 13.9 12.5 0.057 13.2 12.5 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain zf-RING_4 PF14570.4 001105673.1_37923001_1 - 0.13 11.9 8.3 1.2 8.8 8.6 2.4 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain GLE1 PF07817.11 001105673.1_37923001_1 - 0.14 11.2 5.2 0.33 10.0 5.2 1.7 1 0 0 1 1 1 0 GLE1-like protein DUF4407 PF14362.4 001105673.1_37923001_1 - 0.36 10.0 5.7 0.47 9.6 5.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Glyco_hydro_67N PF03648.12 001105673.1_37923001_1 - 0.48 10.6 3.7 27 4.9 3.1 2.4 2 0 0 2 2 2 0 Glycosyl hydrolase family 67 N-terminus Pga1 PF10333.7 001105673.1_37923001_1 - 0.55 9.9 3.8 0.28 10.9 0.9 1.9 2 0 0 2 2 2 0 GPI-Mannosyltransferase II co-activator zf-rbx1 PF12678.5 001105673.1_37923001_1 - 1.3 9.3 11.4 0.15 12.2 5.7 2.5 2 1 0 2 2 1 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.4 001105673.1_37923001_1 - 1.8 8.3 14.4 2.3 8.0 9.6 3.0 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 Nitr_red_assoc PF09655.8 001105673.1_37923001_1 - 2.2 8.8 11.7 0.18 12.3 1.4 2.4 1 1 1 2 2 2 0 Conserved nitrate reductase-associated protein (Nitr_red_assoc) ECM11 PF15463.4 001105673.1_37923001_1 - 3 8.3 14.4 1.1 9.7 4.8 3.2 3 0 0 3 3 3 0 Extracellular mutant protein 11 DUF883 PF05957.11 001105673.1_37923001_1 - 3.2 8.2 5.7 10 6.7 1.1 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF342 PF03961.11 001105673.1_37923001_1 - 4.7 5.6 16.2 11 4.4 16.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF342) DUF1664 PF07889.10 001105673.1_37923001_1 - 6.7 6.6 13.1 3.1 7.7 6.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) UPAR_LY6 PF00021.19 001280485.1_39724001_1 - 0.026 15.1 13.5 0.026 15.1 13.5 2.4 2 1 0 2 2 2 0 u-PAR/Ly-6 domain BIR PF00653.19 001171325.1_37923001_1 - 1.8e-59 198.2 19.8 3.5e-22 78.7 2.1 4.6 5 0 0 5 5 5 3 Inhibitor of Apoptosis domain zf-C3HC4_3 PF13920.4 001171325.1_37923001_1 - 5.1e-13 48.5 8.9 5.1e-13 48.5 8.9 3.0 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 001171325.1_37923001_1 - 2e-06 27.4 8.0 5.1e-06 26.1 8.0 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 DUF2039 PF10217.7 001171325.1_37923001_1 - 0.18 12.0 5.4 0.65 10.2 5.4 2.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) RNA_pol_N PF01194.15 001171325.1_37923001_1 - 0.45 10.7 10.3 4.6 7.5 0.1 4.1 4 0 0 4 4 4 0 RNA polymerases N / 8 kDa subunit TRAM_LAG1_CLN8 PF03798.14 001194050.1_29623001_1 - 1.1e-11 44.7 23.5 1.1e-11 44.7 23.5 1.7 2 0 0 2 2 2 1 TLC domain WWE PF02825.18 001280480.1_39725001_1 - 2.2e-33 114.5 0.6 3.3e-16 59.5 0.0 2.3 2 0 0 2 2 2 2 WWE domain zf-C3HC4 PF00097.23 001280480.1_39725001_1 - 7.8e-05 22.3 2.8 7.8e-05 22.3 2.8 2.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 001280480.1_39725001_1 - 0.00019 21.5 1.4 0.00047 20.3 1.4 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.4 001280480.1_39725001_1 - 0.0038 17.3 4.0 0.0038 17.3 4.0 2.5 2 1 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.3 001280480.1_39725001_1 - 0.0045 16.6 3.6 0.062 12.9 0.1 2.6 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.4 001280480.1_39725001_1 - 0.0074 16.1 0.7 0.0074 16.1 0.7 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.5 001280480.1_39725001_1 - 0.0077 16.1 0.4 0.027 14.4 0.4 2.0 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-UDP PF14569.4 001280480.1_39725001_1 - 0.036 14.1 0.4 0.091 12.8 0.4 1.6 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-LITAF-like PF10601.7 001280480.1_39725001_1 - 0.095 12.8 1.5 0.32 11.1 1.5 2.0 1 0 0 1 1 1 0 LITAF-like zinc ribbon domain zf-C3HC4_2 PF13923.4 001280480.1_39725001_1 - 0.52 10.1 6.1 2.1 8.1 2.3 2.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Peptidase_M20 PF01546.26 001246419.1_39726001_1 - 2.5e-36 125.2 0.0 3.2e-36 124.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.12 001246419.1_39726001_1 - 6.2e-15 54.9 0.0 9.9e-15 54.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.15 001246419.1_39726001_1 - 0.17 11.5 0.0 0.27 10.8 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M28 Retrotrans_gag PF03732.15 001190875.1_29629001_1 - 0.00035 20.7 0.0 0.00066 19.8 0.0 1.5 1 0 0 1 1 1 1 Retrotransposon gag protein DUF4939 PF16297.3 001190875.1_29629001_1 - 0.14 11.9 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4939) Peptidase_M20 PF01546.26 001257758.2_29624001_3 - 2.7e-35 121.8 0.0 3.5e-35 121.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.12 001257758.2_29624001_3 - 1e-14 54.2 0.0 1.8e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain JUPITER PF17054.3 001260714.1_29622001_3 - 2.7e-11 43.4 5.8 3.8e-07 29.8 0.1 3.5 2 1 2 4 4 4 2 Microtubule-Associated protein Jupiter Nucleoporin_FG PF13634.4 001260714.1_29622001_3 - 0.17 12.6 4.1 0.55 11.0 4.1 1.9 1 1 0 1 1 1 0 Nucleoporin FG repeat region Peptidase_M20 PF01546.26 001134143.1_43526001_3 - 3.8e-34 118.1 0.0 5e-34 117.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.12 001134143.1_43526001_3 - 7.4e-15 54.7 0.0 1.2e-14 54.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Lectin_C PF00059.19 001145866.1_49822001_1 - 4e-19 69.2 1.6 4e-19 69.2 1.6 1.6 1 1 1 2 2 2 1 Lectin C-type domain UL45 PF05473.10 001145866.1_49822001_1 - 7.8e-06 25.5 0.3 1.1e-05 25.1 0.3 1.2 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like DUF716 PF04819.10 001350002.1_45724001_3 - 3.4e-34 117.4 9.5 3.4e-34 117.4 9.5 2.6 3 0 0 3 3 3 1 Family of unknown function (DUF716) COX7B PF05392.9 001350002.1_45724001_3 - 0.36 10.4 2.1 3.2 7.3 0.1 2.4 2 0 0 2 2 2 0 Cytochrome C oxidase chain VIIB EF-hand_8 PF13833.4 146233.1_26229120_1 - 0.00029 20.4 0.1 0.0039 16.8 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.4 146233.1_26229120_1 - 0.0013 19.1 0.4 0.014 15.7 0.3 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.30 146233.1_26229120_1 - 0.0046 16.3 1.4 0.0098 15.2 0.7 2.0 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 146233.1_26229120_1 - 0.0093 15.7 1.0 0.023 14.5 0.3 2.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.4 146233.1_26229120_2 - 1.6e-08 34.0 5.3 2.9e-08 33.2 0.1 3.5 4 1 0 4 4 4 1 EF-hand domain pair EF-hand_6 PF13405.4 146233.1_26229120_2 - 4.7e-05 22.9 2.1 0.00073 19.2 0.5 3.3 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.4 146233.1_26229120_2 - 8.2e-05 22.9 4.8 0.00027 21.2 0.9 3.1 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.30 146233.1_26229120_2 - 0.00025 20.2 0.9 0.00025 20.2 0.9 3.6 5 0 0 5 5 5 1 EF hand Filament PF00038.19 146392.1_26225120_1 - 5.1e-105 351.3 20.0 6.1e-105 351.1 20.0 1.0 1 0 0 1 1 1 1 Intermediate filament protein DUF4446 PF14584.4 146392.1_26225120_1 - 2.4 8.0 7.5 15 5.4 0.0 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF4446) Fib_alpha PF08702.8 146392.1_26225120_1 - 4.7 7.3 12.6 4 7.5 1.1 3.7 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family UDPGT PF00201.16 001350029.1_29525001_1 - 1.6e-247 822.1 0.3 1.9e-247 821.8 0.3 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001350029.1_29525001_1 - 2.6e-08 33.9 0.0 4.6e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.4 001350029.1_29525001_1 - 0.0012 18.7 0.4 0.0057 16.5 0.4 1.9 1 1 0 1 1 1 1 Glycosyltransferase Family 4 ARL6IP6 PF15062.4 146424.1_26224120_1 - 2.1e-26 91.7 0.0 3.3e-26 91.1 0.0 1.3 1 0 0 1 1 1 1 Haemopoietic lineage transmembrane helix SMN PF06003.10 001166020.1_45721001_1 - 7.8 5.5 5.7 10 5.1 5.7 1.1 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) SFTA2 PF15210.4 001166020.1_45721001_2 - 6.8e-28 96.2 1.3 6.8e-28 96.2 1.3 1.7 2 0 0 2 2 2 1 Surfactant-associated protein 2 TLV_coat PF00429.17 001308065.1_24224001_1 - 3.2e-29 101.9 3.2 3.3e-29 101.9 0.0 2.3 2 1 0 2 2 2 1 ENV polyprotein (coat polyprotein) TLV_coat PF00429.17 001305070.1_40427001_3 - 1.2e-66 225.5 5.6 2.9e-63 214.3 2.7 2.2 2 0 0 2 2 2 2 ENV polyprotein (coat polyprotein) TLV_coat PF00429.17 001307973.1_40425001_3 - 5.2e-29 101.2 0.0 5.2e-29 101.2 0.0 2.0 2 1 1 3 3 3 1 ENV polyprotein (coat polyprotein) DDE_1 PF03184.17 001244259.1_49825001_1 - 4.3e-44 150.0 0.0 6.6e-44 149.4 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease BrkDBD PF09607.8 001244259.1_49825001_1 - 9.9e-26 89.2 0.1 2.2e-25 88.1 0.1 1.6 1 0 0 1 1 1 1 Brinker DNA-binding domain KRAB PF01352.25 001244259.1_49825001_1 - 5.1e-16 57.9 1.0 1.1e-15 56.9 1.0 1.6 1 0 0 1 1 1 1 KRAB box HTH_Tnp_Tc5 PF03221.14 001244259.1_49825001_1 - 1.7e-13 50.3 0.0 5e-13 48.7 0.0 1.9 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain TLV_coat PF00429.17 001306047.1_29728001_3 - 3.6e-66 223.9 6.3 5e-63 213.5 3.3 2.2 2 0 0 2 2 2 2 ENV polyprotein (coat polyprotein) BRICHOS PF04089.12 198972.1_45722001_3 - 4.7e-25 87.4 0.0 7.3e-25 86.7 0.0 1.3 1 0 0 1 1 1 1 BRICHOS domain TLV_coat PF00429.17 001307974.2_39726001_2 - 8.4e-29 100.5 0.0 8.4e-29 100.5 0.0 2.1 2 1 0 2 2 2 1 ENV polyprotein (coat polyprotein) DDE_1 PF03184.17 001169074.1_40429001_1 - 2.7e-12 46.5 0.0 6.9e-12 45.2 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.14 001169074.1_40429001_1 - 3e-09 36.6 1.2 5.1e-09 35.9 0.1 1.9 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain zf-C2H2_4 PF13894.4 001169074.1_40429001_1 - 1.3e-05 25.5 75.4 0.1 13.4 0.5 10.0 10 0 0 10 10 10 5 C2H2-type zinc finger HTH_28 PF13518.4 001169074.1_40429001_1 - 0.0022 18.0 0.2 0.0048 16.9 0.2 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain zf-RRN7 PF11781.6 001169074.1_40429001_1 - 0.0097 15.4 5.7 1.2 8.7 0.1 3.2 2 0 0 2 2 2 2 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DDE_3 PF13358.4 001169074.1_40429001_1 - 0.053 13.2 0.2 0.21 11.2 0.0 2.0 2 0 0 2 2 2 0 DDE superfamily endonuclease HTH_23 PF13384.4 001169074.1_40429001_1 - 0.071 12.8 0.2 0.3 10.8 0.1 2.1 2 0 0 2 2 2 0 Homeodomain-like domain zf-C2H2_jaz PF12171.6 001169074.1_40429001_1 - 2.6 8.3 30.0 0.23 11.7 0.3 6.2 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding LBP_BPI_CETP PF01273.23 001301405.2_39523001_2 - 7.5e-40 136.1 3.2 1e-39 135.7 3.2 1.2 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain LRR_9 PF14580.4 001251900.1_39722001_1 - 4e-13 49.1 3.2 1.3e-12 47.5 3.2 1.8 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.5 001251900.1_39722001_1 - 7.1e-07 29.3 15.4 5.7e-06 26.4 6.1 4.0 2 1 2 4 4 4 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001251900.1_39722001_1 - 0.0059 16.2 14.6 0.14 11.8 2.5 3.2 3 1 0 3 3 3 2 Leucine rich repeat LRR_6 PF13516.4 001251900.1_39722001_1 - 0.27 11.2 6.3 7.9 6.7 0.3 3.7 3 0 0 3 3 3 0 Leucine Rich repeat Lectin_C PF00059.19 024263.1_32924120_2 - 6.4e-16 58.9 0.2 1.4e-15 57.9 0.2 1.5 1 0 0 1 1 1 1 Lectin C-type domain RRM_1 PF00076.20 001318073.1_39522001_1 - 8.5e-22 76.6 0.0 1.2e-21 76.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 001318073.1_39522001_1 - 0.033 14.1 0.0 0.056 13.4 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif RRM_occluded PF16842.3 001318073.1_39522001_1 - 0.037 13.8 0.0 0.056 13.2 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif Apt1 PF10351.7 001318073.1_39522001_1 - 0.038 12.7 13.7 0.046 12.5 13.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain MIP-T3 PF10243.7 001318073.1_39522001_1 - 0.11 11.0 8.8 0.12 10.9 8.8 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 NPR3 PF03666.11 001318073.1_39522001_1 - 1.8 7.1 8.2 2.3 6.8 8.2 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.15 001318073.1_39522001_1 - 5.2 5.6 9.1 6.6 5.2 9.1 1.1 1 0 0 1 1 1 0 Presenilin Pneumo_att_G PF05539.9 001318073.1_39522001_1 - 8.1 5.8 10.2 11 5.4 10.2 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G T4_deiodinase PF00837.15 001122652.2_29624001_1 - 5.9e-102 339.8 0.0 7.4e-102 339.5 0.0 1.1 1 0 0 1 1 1 1 Iodothyronine deiodinase CDP-OH_P_transf PF01066.19 001135563.2_29629001_1 - 1.4e-16 60.8 0.1 5.9e-16 58.9 0.1 2.2 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase Pyr_redox_2 PF07992.12 001122669.2_39728001_1 - 7.2e-55 186.2 0.4 8.9e-55 185.9 0.4 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.20 001122669.2_39728001_1 - 3e-28 98.1 0.0 5.7e-28 97.2 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.25 001122669.2_39728001_1 - 2.1e-18 66.5 3.1 2.9e-15 56.5 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 001122669.2_39728001_1 - 8.1e-15 54.7 0.6 1.1e-10 41.1 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 001122669.2_39728001_1 - 5.5e-07 28.9 0.6 1.1e-06 27.9 0.3 1.6 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.5 001122669.2_39728001_1 - 0.00015 21.2 0.0 0.00019 20.8 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.12 001122669.2_39728001_1 - 0.0002 20.0 0.4 0.00047 18.8 0.2 1.6 2 0 0 2 2 2 1 HI0933-like protein AlaDh_PNT_C PF01262.19 001122669.2_39728001_1 - 0.00031 20.0 0.1 0.02 14.1 0.0 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.15 001122669.2_39728001_1 - 0.0018 17.4 0.5 0.0037 16.4 0.0 1.6 2 0 0 2 2 2 1 Thi4 family GIDA PF01134.20 001122669.2_39728001_1 - 0.0022 17.0 0.4 0.0037 16.3 0.4 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.4 001122669.2_39728001_1 - 0.0043 17.1 0.3 0.0043 17.1 0.3 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 001122669.2_39728001_1 - 0.011 15.3 0.8 0.016 14.7 0.2 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.17 001122669.2_39728001_1 - 0.036 13.2 0.1 0.036 13.2 0.1 2.0 2 0 0 2 2 2 0 FAD binding domain NAD_binding_7 PF13241.4 001122669.2_39728001_1 - 0.067 13.5 0.3 7.3 7.0 0.1 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding GSHPx PF00255.17 001118889.2_29622001_1 - 4.5e-42 141.9 0.1 5.9e-42 141.5 0.1 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.19 001118889.2_29622001_1 - 0.0052 16.6 0.0 0.086 12.6 0.0 2.2 1 1 0 1 1 1 1 AhpC/TSA family GSHPx PF00255.17 001346420.1_29623001_3 - 5.9e-42 141.5 0.1 7.7e-42 141.1 0.1 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.19 001346420.1_29623001_3 - 0.0077 16.0 0.0 0.11 12.2 0.0 2.2 1 1 0 1 1 1 1 AhpC/TSA family EF-hand_1 PF00036.30 001347992.1_29629001_2 - 0.0069 15.7 0.0 0.014 14.8 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.4 001347992.1_29629001_2 - 0.025 14.4 0.0 0.064 13.1 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.4 001347992.1_29629001_2 - 0.038 14.3 0.0 0.078 13.3 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair RskA PF10099.7 001347992.1_29629001_2 - 1.7 8.8 13.5 0.2 11.8 6.6 2.6 3 0 0 3 3 3 0 Anti-sigma-K factor rskA SelP_N PF04592.12 001159490.2_29625001_3 - 6.7e-102 339.7 3.2 9.4e-102 339.2 3.2 1.2 1 0 0 1 1 1 1 Selenoprotein P, N terminal region SelP_C PF04593.12 001159490.2_29625001_3 - 1.4e-30 105.9 8.4 3.9e-30 104.5 8.4 1.8 1 0 0 1 1 1 1 Selenoprotein P, C terminal region Arf PF00025.19 138060.1_26223120_1 - 7e-12 45.0 0.0 9.9e-12 44.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Sep15_SelM PF08806.9 144533.1_29623120_2 - 5.3e-22 77.7 0.0 1.1e-21 76.7 0.0 1.5 1 0 0 1 1 1 1 Sep15/SelM redox domain Bax1-I PF01027.18 001039612.2_45723001_1 - 8.6e-37 126.8 30.3 1.2e-36 126.4 30.3 1.2 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 BaxI_1 PF12811.5 001039612.2_45723001_1 - 2.7e-07 30.3 11.1 3.8e-07 29.8 11.1 1.2 1 0 0 1 1 1 1 Bax inhibitor 1 like Hum_adeno_E3A PF05393.9 001039612.2_45723001_1 - 0.21 11.5 4.1 0.54 10.1 4.1 1.7 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein DUF2157 PF09925.7 001039612.2_45723001_1 - 6.4 6.4 17.3 1.8 8.3 9.0 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) Ribosomal_L7Ae PF01248.24 001033063.1_45723001_1 - 1.2e-13 50.5 0.0 3.5e-13 49.0 0.0 1.8 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family MecA PF05389.10 001033063.1_45723001_1 - 0.0066 16.0 2.1 0.0099 15.4 2.1 1.3 1 0 0 1 1 1 1 Negative regulator of genetic competence (MecA) DUF4939 PF16297.3 001100998.1_45723001_1 - 1.2e-52 176.4 0.1 2e-52 175.7 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) DDE_1 PF03184.17 146626.1_26224120_3 - 2.5e-05 23.8 0.1 3.8e-05 23.2 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF4939 PF16297.3 001134358.4_49829001_1 - 2.1e-12 46.8 0.0 4.2e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Retrotrans_gag PF03732.15 001134358.4_49829001_1 - 2.7e-09 37.1 0.0 6.6e-09 35.8 0.0 1.7 1 0 0 1 1 1 1 Retrotransposon gag protein gag-asp_proteas PF13975.4 001134358.4_49829001_1 - 1.1e-07 32.1 0.0 4.3e-07 30.3 0.0 2.0 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.4 001134358.4_49829001_1 - 1.2e-05 25.8 0.0 3.7e-05 24.2 0.0 1.9 2 0 0 2 2 2 1 Aspartyl protease RVP_2 PF08284.9 001134358.4_49829001_1 - 4.3e-05 23.4 0.0 8.9e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease RVT_1 PF00078.25 001134358.4_49829001_1 - 0.00021 20.7 0.0 0.00039 19.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Voltage_CLC PF00654.18 001082029.1_37925001_1 - 2.3e-109 365.8 20.9 3.2e-109 365.3 20.9 1.2 1 0 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.26 001082029.1_37925001_1 - 4.3e-13 49.3 0.6 7.1e-07 29.5 0.1 2.5 2 0 0 2 2 2 2 CBS domain Voltage_CLC PF00654.18 001082068.1_37925001_1 - 6.9e-112 374.0 19.4 6.9e-112 374.0 19.4 1.5 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.26 001082068.1_37925001_1 - 1.5e-13 50.9 2.4 1.3e-05 25.4 0.3 2.5 2 0 0 2 2 2 2 CBS domain EF-hand_6 PF13405.4 001082644.1_37922001_2 - 1.3e-20 71.4 0.7 0.00053 19.6 0.0 4.9 5 1 1 6 6 6 4 EF-hand domain EF-hand_7 PF13499.4 001082644.1_37922001_2 - 6.4e-19 68.1 0.1 1.6e-08 34.7 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 001082644.1_37922001_2 - 2.2e-17 61.1 0.0 0.00031 19.9 0.0 5.1 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.4 001082644.1_37922001_2 - 3.4e-10 39.4 0.2 1.1e-06 28.1 0.0 3.8 3 2 1 4 4 4 1 EF-hand domain pair EF-hand_5 PF13202.4 001082644.1_37922001_2 - 6.5e-09 34.8 0.6 0.053 12.9 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_10 PF14788.4 001082644.1_37922001_2 - 0.18 11.6 0.0 1.2 8.9 0.0 2.3 2 1 1 3 3 3 0 EF hand HflK_N PF12221.6 001082644.1_37922001_2 - 2.5 8.1 12.1 1.3 9.0 0.1 3.8 4 0 0 4 4 4 0 Bacterial membrane protein N terminal DAO PF01266.22 001082189.1_37925001_3 - 1.6e-39 136.4 0.1 2.1e-39 136.0 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.25 001082189.1_37925001_3 - 0.03 14.8 0.0 1.2 9.7 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Caveolin PF01146.15 001348937.1_49825001_1 - 5.1e-59 197.9 1.8 5.1e-59 197.9 1.8 2.1 2 0 0 2 2 2 1 Caveolin Gly_acyl_tr_N PF06021.9 001133334.1_43524001_2 - 3.3e-87 291.7 0.6 4.5e-87 291.2 0.6 1.2 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase Gly_acyl_tr_C PF08444.8 001133334.1_43524001_2 - 3e-45 152.2 0.5 6.1e-45 151.3 0.5 1.5 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region Voltage_CLC PF00654.18 001172931.1_09925001_3 - 4e-111 371.5 20.2 4e-111 371.5 20.2 1.4 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.26 001172931.1_09925001_3 - 1.4e-13 50.9 2.3 1.4e-05 25.3 0.3 2.5 2 0 0 2 2 2 2 CBS domain Epimerase_2 PF02350.17 053765.2_45726001_1 - 5.2e-66 222.7 0.1 8.1e-66 222.1 0.1 1.3 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase ROK PF00480.18 053765.2_45726001_1 - 9.2e-55 186.0 1.8 1.6e-54 185.3 1.8 1.4 1 0 0 1 1 1 1 ROK family FGGY_N PF00370.19 053765.2_45726001_1 - 0.0024 17.3 0.0 0.0043 16.5 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain DRTGG PF07085.10 053765.2_45726001_1 - 0.0025 17.5 0.2 0.0073 15.9 0.2 1.8 1 0 0 1 1 1 1 DRTGG domain Hexokinase_1 PF00349.19 053765.2_45726001_1 - 0.0091 15.9 0.0 0.018 14.9 0.0 1.4 1 0 0 1 1 1 1 Hexokinase Glucokinase PF02685.14 053765.2_45726001_1 - 0.13 11.1 0.6 0.47 9.3 0.0 2.1 2 0 0 2 2 2 0 Glucokinase Peptidase_M9 PF01752.15 053765.2_45726001_1 - 0.14 11.3 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Collagenase B56 PF01603.18 001082363.1_37925001_3 - 3.5e-186 619.0 1.6 4.5e-186 618.7 1.6 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) FTCD_C PF04961.10 001082363.1_37925001_3 - 0.15 11.7 0.1 0.25 10.9 0.1 1.2 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase PMP22_Claudin PF00822.18 001160083.1_49822001_2 - 4.6e-29 101.3 7.8 5.8e-29 101.0 7.8 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001160083.1_49822001_2 - 8.8e-09 35.2 11.7 2.9e-08 33.6 11.5 1.9 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF4064 PF13273.4 001160083.1_49822001_2 - 0.00088 19.5 9.3 0.053 13.7 8.8 2.9 2 1 0 2 2 2 1 Protein of unknown function (DUF4064) Clc-like PF07062.10 001160083.1_49822001_2 - 0.04 13.2 0.2 0.04 13.2 0.2 2.3 2 1 0 2 2 2 0 Clc-like Claudin_3 PF06653.9 001160083.1_49822001_2 - 0.12 12.2 9.0 0.25 11.2 8.8 1.5 1 1 0 1 1 1 0 Tight junction protein, Claudin-like Jiraiya PF15038.4 001160083.1_49822001_2 - 0.13 11.6 4.7 0.28 10.5 4.5 1.8 1 1 0 1 1 1 0 Jiraiya SUR7 PF06687.10 001160083.1_49822001_2 - 0.16 11.5 5.3 0.24 10.9 5.3 1.3 1 0 0 1 1 1 0 SUR7/PalI family DUF4190 PF13828.4 001160083.1_49822001_2 - 0.41 10.3 14.8 3.3 7.4 4.0 3.7 3 1 0 3 3 3 0 Domain of unknown function (DUF4190) Hum_adeno_E3A PF05393.9 001160083.1_49822001_2 - 0.54 10.1 0.1 0.54 10.1 0.1 2.6 2 2 1 3 3 3 0 Human adenovirus early E3A glycoprotein Phage_holin_3_6 PF07332.9 001160083.1_49822001_2 - 5 7.1 17.9 9 6.3 2.4 2.6 1 1 1 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Patatin PF01734.20 001171272.1_37927001_3 - 1.1e-22 81.1 0.0 1.8e-22 80.4 0.0 1.4 1 0 0 1 1 1 1 Patatin-like phospholipase SMC_ScpB PF04079.14 001171272.1_37927001_3 - 0.076 12.5 0.1 0.19 11.2 0.1 1.6 1 0 0 1 1 1 0 Segregation and condensation complex subunit ScpB PRA1 PF03208.17 001031795.1_49822001_1 - 2.2e-38 130.9 1.8 2.6e-38 130.7 1.8 1.0 1 0 0 1 1 1 1 PRA1 family protein Caveolin PF01146.15 214438.3_49826001_3 - 5.8e-59 197.7 1.8 5.8e-59 197.7 1.8 2.1 2 0 0 2 2 2 1 Caveolin IL15 PF02372.13 001009734.1_39521001_1 - 8.1e-57 190.9 5.6 8.1e-57 190.9 5.6 1.6 2 0 0 2 2 2 1 Interleukin 15 Casc1_N PF15927.3 001009734.1_39521001_1 - 0.03 13.9 1.8 0.034 13.7 1.3 1.3 1 1 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus PSDC PF12588.6 001009734.1_39521001_1 - 0.12 12.2 0.8 19 5.1 0.1 2.8 1 1 2 3 3 3 0 Phophatidylserine decarboxylase Pkr1 PF08636.8 001009734.1_39521001_1 - 0.57 10.2 3.5 0.51 10.4 1.0 2.1 1 1 1 2 2 2 0 ER protein Pkr1 RGS PF00615.17 001261654.1_29622001_1 - 1.7e-32 112.0 6.9 3.4e-32 111.1 6.9 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.9 001261654.1_29622001_1 - 0.0041 16.7 0.2 0.0062 16.1 0.2 1.3 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain FliL PF03748.12 001261654.1_29622001_1 - 0.34 11.4 2.2 2.6 8.5 0.4 2.6 1 1 2 3 3 3 0 Flagellar basal body-associated protein FliL TPR_12 PF13424.4 001284938.1_29525001_2 - 1.1e-37 128.1 26.8 5.3e-11 42.5 3.3 5.5 3 2 1 5 5 5 5 Tetratricopeptide repeat GoLoco PF02188.15 001284938.1_29525001_2 - 3e-36 122.3 32.3 5.3e-10 38.5 0.2 4.7 4 0 0 4 4 4 4 GoLoco motif TPR_1 PF00515.26 001284938.1_29525001_2 - 7.1e-32 107.8 28.7 1e-05 25.0 0.5 7.9 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_7 PF13176.4 001284938.1_29525001_2 - 2.3e-28 95.9 20.0 9.4e-06 25.2 0.4 8.3 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.15 001284938.1_29525001_2 - 1.2e-19 68.6 23.1 0.0027 17.5 0.5 7.8 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_8 PF13181.4 001284938.1_29525001_2 - 3.1e-18 64.3 19.8 0.0017 18.3 0.4 7.8 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_10 PF13374.4 001284938.1_29525001_2 - 7.3e-18 63.7 21.1 0.006 16.3 0.0 8.0 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_4 PF07721.12 001284938.1_29525001_2 - 1.2e-08 34.7 0.0 0.68 10.6 0.1 6.1 6 0 0 6 6 5 2 Tetratricopeptide repeat Rapsyn_N PF10579.7 001284938.1_29525001_2 - 2.8e-05 24.0 1.1 6.2 6.9 0.1 4.8 3 2 2 5 5 5 2 Rapsyn N-terminal myristoylation and linker region TPR_14 PF13428.4 001284938.1_29525001_2 - 6.1e-05 23.4 5.8 14 6.7 0.0 6.9 6 2 1 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.4 001284938.1_29525001_2 - 0.00035 21.1 13.7 2.7 8.6 0.1 6.1 5 2 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.4 001284938.1_29525001_2 - 0.0034 17.5 14.0 27 5.3 0.0 7.0 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_11 PF13414.4 001284938.1_29525001_2 - 0.0058 16.1 20.5 0.51 9.9 0.4 6.9 7 0 0 7 7 7 1 TPR repeat TPR_6 PF13174.4 001284938.1_29525001_2 - 0.017 15.6 3.1 1e+02 3.8 0.1 6.0 7 0 0 7 7 6 0 Tetratricopeptide repeat ANAPC3 PF12895.5 001284938.1_29525001_2 - 0.047 13.8 11.0 1.7 8.8 1.3 4.6 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 RGS PF00615.17 001258139.1_29623001_2 - 2e-37 127.9 2.0 3.5e-37 127.2 2.0 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain GoLoco PF02188.15 001123119.1_49824001_1 - 2.5e-21 74.6 10.3 4.2e-07 29.2 1.0 3.5 3 0 0 3 3 3 3 GoLoco motif TPR_12 PF13424.4 001204445.1_37925001_1 - 5e-39 132.3 29.0 2.3e-11 43.7 5.6 5.5 4 1 1 5 5 5 5 Tetratricopeptide repeat GoLoco PF02188.15 001204445.1_37925001_1 - 1.4e-38 129.7 32.0 4.4e-10 38.7 0.2 4.6 4 0 0 4 4 4 4 GoLoco motif TPR_1 PF00515.26 001204445.1_37925001_1 - 3.8e-36 121.3 28.3 5e-06 26.0 0.0 8.0 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_7 PF13176.4 001204445.1_37925001_1 - 7.5e-31 103.7 20.1 3.7e-06 26.4 0.3 8.4 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.15 001204445.1_37925001_1 - 5.1e-22 76.0 22.5 0.0011 18.8 0.7 7.8 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_8 PF13181.4 001204445.1_37925001_1 - 4.3e-21 73.2 19.6 0.00029 20.7 0.5 7.8 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_10 PF13374.4 001204445.1_37925001_1 - 2.6e-19 68.3 21.6 0.0047 16.6 0.0 8.1 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_4 PF07721.12 001204445.1_37925001_1 - 3.4e-09 36.3 0.0 0.56 10.9 0.1 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat Rapsyn_N PF10579.7 001204445.1_37925001_1 - 1.5e-06 28.1 1.6 3.2 7.8 0.0 5.3 4 2 2 6 6 6 1 Rapsyn N-terminal myristoylation and linker region TPR_14 PF13428.4 001204445.1_37925001_1 - 9.9e-06 25.8 8.0 11 7.1 0.0 7.5 6 2 2 8 8 7 1 Tetratricopeptide repeat TPR_16 PF13432.4 001204445.1_37925001_1 - 0.00018 22.0 13.4 0.91 10.1 0.2 6.3 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.4 001204445.1_37925001_1 - 0.00065 19.8 13.9 18 5.9 0.0 7.2 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.4 001204445.1_37925001_1 - 0.001 19.5 1.8 47 4.8 0.1 6.3 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_11 PF13414.4 001204445.1_37925001_1 - 0.0044 16.5 23.8 0.22 11.1 0.3 7.3 6 2 1 7 7 7 1 TPR repeat ANAPC3 PF12895.5 001204445.1_37925001_1 - 0.01 15.9 11.7 2 8.6 1.8 4.8 3 1 2 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 RGS PF00615.17 001194745.1_29623001_2 - 3.2e-34 117.6 0.1 4.1e-34 117.2 0.1 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS PF00615.17 001185184.1_49826001_3 - 5e-35 120.2 4.5 7.5e-35 119.6 4.5 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS PF00615.17 001265925.1_29623001_1 - 3.6e-38 130.3 4.9 6.1e-38 129.6 4.9 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS PF00615.17 001174111.1_39522001_1 - 8.5e-37 125.9 4.3 1.2e-36 125.4 4.3 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS PF00615.17 001265721.1_29626001_2 - 5.3e-34 116.9 0.4 5.3e-34 116.9 0.4 2.2 3 0 0 3 3 3 1 Regulator of G protein signaling domain DEP PF00610.19 001265721.1_29626001_2 - 2.6e-17 62.5 0.0 6.9e-17 61.1 0.0 1.8 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) G-gamma PF00631.20 001265721.1_29626001_2 - 9.1e-12 44.7 0.1 2.4e-11 43.4 0.1 1.7 1 0 0 1 1 1 1 GGL domain RGS-like PF09128.9 001265721.1_29626001_2 - 0.14 11.7 0.5 0.31 10.6 0.0 1.7 2 1 0 2 2 2 0 Regulator of G protein signalling-like domain Syntaxin_2 PF14523.4 001243809.1_49824001_3 - 0.027 14.7 0.1 1.5 9.1 0.0 2.4 2 0 0 2 2 2 0 Syntaxin-like protein Yuri_gagarin PF15934.3 001243809.1_49824001_3 - 0.095 12.4 0.6 0.17 11.6 0.1 1.6 2 0 0 2 2 2 0 Yuri gagarin EF-hand_7 PF13499.4 001009874.3_22422001_3 - 3.7e-12 46.4 0.8 1.1e-05 25.7 0.4 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 001009874.3_22422001_3 - 1.3e-10 40.2 3.2 6.5e-07 28.7 0.7 3.1 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.30 001009874.3_22422001_3 - 5.9e-10 37.9 6.6 1.8e-06 27.0 0.8 3.6 4 1 0 4 4 4 2 EF hand EF-hand_8 PF13833.4 001009874.3_22422001_3 - 3.9e-07 29.6 8.1 5.4e-05 22.8 0.8 4.3 1 1 3 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.4 001009874.3_22422001_3 - 0.00041 19.6 4.4 0.0006 19.1 2.2 2.3 2 0 0 2 2 2 1 EF hand EF-hand_4 PF12763.5 001009874.3_22422001_3 - 0.0068 16.2 0.2 0.086 12.7 0.0 2.1 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 001009874.3_22422001_3 - 0.099 12.8 0.1 0.32 11.2 0.0 1.8 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region UQ_con PF00179.24 001082694.1_37926001_1 - 3.9e-09 36.2 0.0 2.8e-08 33.4 0.0 2.3 2 1 0 2 2 2 1 Ubiquitin-conjugating enzyme RWD PF05773.20 001082694.1_37926001_1 - 0.0022 18.1 0.3 0.017 15.3 0.1 2.2 2 0 0 2 2 2 1 RWD domain Prok-E2_B PF14461.4 001082694.1_37926001_1 - 0.093 12.3 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 Prokaryotic E2 family B G-alpha PF00503.18 001082715.1_37923001_1 - 1.3e-106 356.6 0.0 1.7e-106 356.3 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 001082715.1_37923001_1 - 1e-12 47.7 0.3 1.3e-09 37.6 0.0 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001082715.1_37923001_1 - 0.0005 19.3 0.3 0.058 12.6 0.0 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001082715.1_37923001_1 - 0.069 13.1 0.0 5.3 7.0 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase Roc PF08477.11 001082715.1_37923001_1 - 0.094 12.8 0.3 5.6 7.1 0.1 2.5 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.4 001082715.1_37923001_1 - 0.18 11.4 0.0 0.34 10.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sulfotransfer_1 PF00685.25 001082711.1_37923001_2 - 6e-91 304.5 0.3 7.1e-91 304.2 0.3 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 001082711.1_37923001_2 - 4.2e-05 23.9 0.1 0.012 15.8 0.0 2.2 2 0 0 2 2 2 2 Sulfotransferase family Aminotran_5 PF00266.17 001082309.1_37923001_3 - 4.2e-67 226.6 0.0 4.9e-67 226.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.19 001082309.1_37923001_3 - 6.5e-06 25.4 0.0 0.011 14.8 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class I and II Ras PF00071.20 001032981.2_32322001_2 - 9.1e-57 191.0 0.0 1.1e-56 190.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001032981.2_32322001_2 - 1.7e-21 76.5 0.0 2.9e-21 75.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001032981.2_32322001_2 - 3.4e-09 36.3 0.0 5e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001032981.2_32322001_2 - 2e-06 27.4 0.5 9.1e-06 25.2 0.1 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001032981.2_32322001_2 - 9.2e-06 25.5 0.0 0.098 12.4 0.0 2.4 2 1 1 3 3 3 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 001032981.2_32322001_2 - 4.2e-05 23.5 0.1 8e-05 22.6 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase G-alpha PF00503.18 001032981.2_32322001_2 - 0.0037 16.3 1.0 0.39 9.7 0.9 2.1 1 1 1 2 2 2 2 G-protein alpha subunit ArgK PF03308.14 001032981.2_32322001_2 - 0.028 13.3 0.1 0.58 9.0 0.0 2.1 2 0 0 2 2 2 0 ArgK protein FeoB_N PF02421.16 001032981.2_32322001_2 - 0.035 13.5 0.0 0.24 10.8 0.0 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B ATP_bind_1 PF03029.15 001032981.2_32322001_2 - 0.064 12.9 0.4 1.2 8.7 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein zf-C3HC4 PF00097.23 001071818.1_39722001_1 - 7.2e-09 35.3 11.6 7.2e-09 35.3 11.6 2.6 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001071818.1_39722001_1 - 8.5e-09 35.2 5.2 8.5e-09 35.2 5.2 2.3 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 001071818.1_39722001_1 - 2.5e-08 33.8 11.8 2.5e-08 33.8 11.8 2.6 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.4 001071818.1_39722001_1 - 6.9e-08 32.5 10.3 6.9e-08 32.5 10.3 2.9 2 1 1 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.4 001071818.1_39722001_1 - 1.1e-06 28.3 11.3 1.1e-06 28.3 11.3 2.6 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001071818.1_39722001_1 - 1.4e-06 28.0 12.5 1.4e-06 28.0 12.5 2.6 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001071818.1_39722001_1 - 6e-05 22.8 12.5 6e-05 22.8 12.5 3.0 3 1 1 4 4 4 1 zinc-RING finger domain Prok-RING_4 PF14447.4 001071818.1_39722001_1 - 0.00031 20.4 14.3 0.00031 20.4 14.3 3.2 2 2 1 3 3 3 2 Prokaryotic RING finger family 4 zf-B_box PF00643.22 001071818.1_39722001_1 - 0.0035 17.3 5.7 0.0035 17.3 5.7 3.1 3 0 0 3 3 3 2 B-box zinc finger DUF5082 PF16888.3 001071818.1_39722001_1 - 0.0036 17.5 0.6 0.007 16.6 0.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5082) zf-rbx1 PF12678.5 001071818.1_39722001_1 - 0.0089 16.2 6.8 0.0089 16.2 6.8 2.6 2 0 0 2 2 2 1 RING-H2 zinc finger domain ATG16 PF08614.9 001071818.1_39722001_1 - 0.012 15.6 6.7 0.017 15.2 6.7 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) CRR7 PF12095.6 001071818.1_39722001_1 - 0.04 14.2 2.0 1.3 9.4 0.2 2.4 1 1 1 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 DUF2433 PF10360.7 001071818.1_39722001_1 - 0.044 13.7 0.1 0.067 13.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2433) BLOC1_2 PF10046.7 001071818.1_39722001_1 - 0.045 13.9 4.8 1.2 9.4 1.2 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3461 PF11944.6 001071818.1_39722001_1 - 0.072 13.1 1.0 0.13 12.3 0.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3461) Spc7 PF08317.9 001071818.1_39722001_1 - 0.11 11.3 7.4 0.13 10.9 7.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Exonuc_VII_L PF02601.13 001071818.1_39722001_1 - 0.11 11.9 1.3 0.13 11.7 1.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit IncA PF04156.12 001071818.1_39722001_1 - 0.16 11.6 7.5 0.24 11.0 7.5 1.4 1 0 0 1 1 1 0 IncA protein Dzip-like_N PF13815.4 001071818.1_39722001_1 - 0.22 11.4 4.4 4.3 7.2 1.9 2.4 2 0 0 2 2 2 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal COG2 PF06148.9 001071818.1_39722001_1 - 0.28 11.1 2.3 0.56 10.2 0.7 2.0 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4355 PF14265.4 001071818.1_39722001_1 - 0.32 11.1 3.9 0.51 10.5 3.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) Rad50_zn_hook PF04423.12 001071818.1_39722001_1 - 0.58 9.9 14.3 0.69 9.7 0.2 3.4 3 1 1 4 4 4 0 Rad50 zinc hook motif FUSC PF04632.10 001071818.1_39722001_1 - 0.6 8.5 3.1 0.74 8.2 3.1 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family TMF_DNA_bd PF12329.6 001071818.1_39722001_1 - 0.71 9.8 8.1 0.18 11.7 3.9 2.0 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding zf-FCS PF06467.12 001071818.1_39722001_1 - 1.4 8.8 11.7 0.072 12.9 6.0 1.8 2 0 0 2 2 1 0 MYM-type Zinc finger with FCS sequence motif zf-RING_4 PF14570.4 001071818.1_39722001_1 - 4.9 6.8 22.8 0.41 10.3 11.2 3.4 1 1 1 3 3 2 0 RING/Ubox like zinc-binding domain DUF4604 PF15377.4 001008329.1_45722001_3 - 1.4e-27 97.2 11.4 1.4e-27 97.2 11.4 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4604) XK-related PF09815.7 001079921.1_39725001_1 - 3.2e-82 276.1 28.1 4.6e-82 275.6 28.1 1.2 1 0 0 1 1 1 1 XK-related protein Dynamin_N PF00350.21 001082281.1_37929001_1 - 9.9e-13 48.4 0.0 1.2e-11 44.8 0.0 2.2 1 1 0 1 1 1 1 Dynamin family EHD_N PF16880.3 001082281.1_37929001_1 - 3.3e-10 39.6 0.0 6.1e-10 38.7 0.0 1.5 1 0 0 1 1 1 1 N-terminal EH-domain containing protein MMR_HSR1 PF01926.21 001082281.1_37929001_1 - 2.2e-08 34.0 0.0 4.4e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001082281.1_37929001_1 - 0.0085 15.9 0.0 0.13 12.1 0.0 2.7 3 0 0 3 3 3 1 Protein of unknown function, DUF258 Nop14 PF04147.10 001082281.1_37929001_1 - 0.025 12.7 16.1 0.036 12.2 16.1 1.2 1 0 0 1 1 1 0 Nop14-like family GTP_EFTU PF00009.25 001082281.1_37929001_1 - 0.094 12.1 0.0 0.21 11.0 0.0 1.5 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Yippee-Mis18 PF03226.12 001071811.1_39722001_3 - 2.5e-30 104.6 7.4 4.1e-30 104.0 7.4 1.3 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Trypsin PF00089.24 001009472.1_39522001_3 - 5.4e-68 229.0 0.0 6.2e-68 228.8 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001009472.1_39522001_3 - 1.3e-06 29.3 0.0 2.2e-06 28.5 0.0 1.3 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001009472.1_39522001_3 - 0.0011 19.3 0.0 0.0022 18.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Med12-LCEWAV PF12145.6 001009019.1_39729001_1 - 2.8e-183 610.0 0.0 2.8e-183 610.0 0.0 2.4 2 0 0 2 2 2 1 Eukaryotic Mediator 12 subunit domain Med12-PQL PF12144.6 001009019.1_39729001_1 - 3.4e-83 278.5 33.4 3.4e-83 278.5 33.4 3.9 3 1 1 4 4 4 1 Eukaryotic Mediator 12 catenin-binding domain PA26 PF04636.11 001009019.1_39729001_1 - 3.8 6.2 21.5 6.8 5.4 21.5 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Sulfotransfer_1 PF00685.25 021769.1_45725001_1 - 7.7e-91 304.1 1.1 9.7e-91 303.8 1.1 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 021769.1_45725001_1 - 4.7e-05 23.7 0.0 0.012 15.9 0.1 2.6 3 0 0 3 3 3 2 Sulfotransferase family COesterase PF00135.26 001009203.1_22424001_1 - 9.4e-172 572.4 0.0 1.1e-171 572.1 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family AChE_tetra PF08674.8 001009203.1_22424001_1 - 2.2e-20 71.9 9.4 3.7e-20 71.2 9.4 1.4 1 0 0 1 1 1 1 Acetylcholinesterase tetramerisation domain Abhydrolase_3 PF07859.11 001009203.1_22424001_1 - 9e-06 25.5 0.4 3e-05 23.8 0.4 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold LCAT PF02450.13 001082190.1_37923001_1 - 1.6e-109 366.5 0.0 8.9e-109 364.1 0.0 1.8 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.5 001082190.1_37923001_1 - 0.00029 21.4 0.1 0.00048 20.7 0.1 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 001082190.1_37923001_1 - 0.0023 17.1 0.0 0.0044 16.2 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.11 001082190.1_37923001_1 - 0.029 14.1 0.0 0.054 13.2 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase DUF1749 PF08538.8 001082190.1_37923001_1 - 0.2 10.6 0.0 0.31 10.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) 7tm_1 PF00001.19 001043346.1_49824001_2 - 9.2e-55 185.6 6.6 1.4e-54 185.0 6.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001043346.1_49824001_2 - 5e-05 22.7 9.4 0.00072 18.9 9.4 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.7 001043346.1_49824001_2 - 0.00028 20.2 0.7 0.00028 20.2 0.7 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw Orexin_rec2 PF03827.11 001043346.1_49824001_2 - 0.0012 18.6 2.0 0.0022 17.8 2.0 1.3 1 0 0 1 1 1 1 Orexin receptor type 2 7tm_4 PF13853.4 001043346.1_49824001_2 - 0.0052 16.4 2.6 0.0052 16.4 2.6 2.0 2 0 0 2 2 2 1 Olfactory receptor Adipogenin PF15202.4 001043346.1_49824001_2 - 0.15 12.0 2.4 4.4 7.3 0.1 2.8 2 0 0 2 2 2 0 Adipogenin 7TM_GPCR_Srx PF10328.7 001043346.1_49824001_2 - 0.35 10.0 7.7 0.039 13.1 2.7 1.8 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx Complex1_LYR PF05347.13 001033140.3_32922001_2 - 2.9e-11 43.1 1.5 6.2e-11 42.1 1.5 1.6 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.4 001033140.3_32922001_2 - 1.7e-08 34.8 5.8 2.8e-07 30.9 0.5 2.2 1 1 1 2 2 2 2 Complex1_LYR-like Complex1_LYR_2 PF13233.4 001033140.3_32922001_2 - 0.015 15.9 0.1 0.027 15.1 0.1 1.5 1 0 0 1 1 1 0 Complex1_LYR-like 7tm_1 PF00001.19 001009375.1_22423001_1 - 3.5e-79 265.7 3.8 4.2e-79 265.4 3.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001009375.1_22423001_1 - 1.1e-16 60.9 0.1 1.9e-16 60.1 0.1 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 001009375.1_22423001_1 - 1.1e-07 31.4 1.4 3.7e-07 29.6 0.7 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.7 001009375.1_22423001_1 - 4.8e-07 29.2 6.4 6.7e-07 28.8 5.7 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001009375.1_22423001_1 - 8.9e-07 28.8 9.2 1.3e-05 25.0 7.3 2.3 2 1 0 2 2 2 1 Olfactory receptor Git3 PF11710.6 001009375.1_22423001_1 - 0.29 10.7 9.2 0.49 10.0 9.2 1.3 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 G-alpha PF00503.18 001044538.2_49823001_1 - 1.2e-114 383.1 3.9 1.4e-114 382.8 3.9 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 001044538.2_49823001_1 - 2.1e-14 53.3 1.7 5.8e-11 42.0 0.3 2.9 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001044538.2_49823001_1 - 0.0015 17.8 3.7 0.036 13.3 0.1 2.8 2 1 0 3 3 3 2 Gtr1/RagA G protein conserved region Roc PF08477.11 001044538.2_49823001_1 - 0.028 14.5 1.4 4.8 7.3 0.1 2.7 1 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.21 001044538.2_49823001_1 - 0.089 12.8 0.1 2 8.4 0.1 2.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase DUF3142 PF11340.6 001044538.2_49823001_1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3142) Apolipoprotein PF01442.16 214388.1_49823001_3 - 3.8e-73 245.4 32.4 9.9e-50 169.0 16.2 3.6 2 1 1 3 3 3 2 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.10 214388.1_49823001_3 - 1.1e-10 41.6 12.1 0.058 13.3 0.2 5.2 1 1 3 5 5 5 3 Baculovirus polyhedron envelope protein, PEP, C terminus YtxH PF12732.5 214388.1_49823001_3 - 1.3e-10 41.5 15.3 0.036 14.5 5.6 6.3 3 2 1 5 5 5 2 YtxH-like protein ApoLp-III PF07464.9 214388.1_49823001_3 - 5e-09 36.3 24.5 0.0012 18.8 7.5 4.6 1 1 3 4 4 4 3 Apolipophorin-III precursor (apoLp-III) DUF1640 PF07798.9 214388.1_49823001_3 - 6.6e-07 29.4 20.5 0.02 14.8 0.4 3.6 1 1 2 3 3 3 3 Protein of unknown function (DUF1640) DUF1664 PF07889.10 214388.1_49823001_3 - 2.2e-06 27.5 12.2 0.5 10.2 0.3 4.9 1 1 5 6 6 6 4 Protein of unknown function (DUF1664) DUF883 PF05957.11 214388.1_49823001_3 - 2.9e-05 24.4 19.2 0.78 10.2 0.3 6.2 1 1 5 7 7 7 3 Bacterial protein of unknown function (DUF883) KapB PF08810.8 214388.1_49823001_3 - 9.4e-05 22.5 10.9 0.44 10.6 0.2 4.8 3 1 3 6 6 6 2 Kinase associated protein B Gp58 PF07902.9 214388.1_49823001_3 - 0.00039 18.9 5.9 0.0033 15.8 2.1 2.1 1 1 1 2 2 2 2 gp58-like protein Fib_alpha PF08702.8 214388.1_49823001_3 - 0.00045 20.3 17.9 0.057 13.5 3.0 3.7 2 1 1 3 3 3 3 Fibrinogen alpha/beta chain family Prominin PF05478.9 214388.1_49823001_3 - 0.00048 18.1 15.1 0.0025 15.7 7.1 2.5 1 1 3 4 4 4 3 Prominin ApoO PF09769.7 214388.1_49823001_3 - 0.00059 19.7 6.4 0.71 9.7 0.2 4.7 1 1 2 4 4 4 1 Apolipoprotein O DUF4455 PF14643.4 214388.1_49823001_3 - 0.00077 18.2 19.9 0.0032 16.1 11.1 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF4455) TEA PF01285.16 214388.1_49823001_3 - 0.0016 17.4 0.6 0.11 11.3 0.2 2.1 2 0 0 2 2 2 1 TEA/ATTS domain family Peptidase_M75 PF09375.8 214388.1_49823001_3 - 0.0037 16.6 11.3 0.12 11.6 3.1 3.1 1 1 2 3 3 3 2 Imelysin Exonuc_VII_L PF02601.13 214388.1_49823001_3 - 0.0042 16.6 22.9 2e+02 1.2 22.9 3.0 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF2884 PF11101.6 214388.1_49823001_3 - 0.0046 16.4 15.9 0.038 13.3 2.6 3.8 1 1 2 3 3 3 2 Protein of unknown function (DUF2884) DivIVA PF05103.11 214388.1_49823001_3 - 0.0051 16.8 21.1 0.012 15.5 1.3 3.8 2 1 2 4 4 3 2 DivIVA protein FliT PF05400.11 214388.1_49823001_3 - 0.0053 17.4 27.1 0.44 11.2 4.2 5.8 2 2 1 4 4 4 1 Flagellar protein FliT SF-assemblin PF06705.9 214388.1_49823001_3 - 0.0057 15.9 14.2 0.78 8.9 4.7 3.7 1 1 3 4 4 4 2 SF-assemblin/beta giardin DUF1845 PF08900.9 214388.1_49823001_3 - 0.0079 15.8 9.1 0.53 9.8 0.2 4.1 2 2 4 6 6 6 1 Domain of unknown function (DUF1845) BshC PF10079.7 214388.1_49823001_3 - 0.013 14.1 24.5 0.087 11.4 3.5 3.3 1 1 2 3 3 3 0 Bacillithiol biosynthesis BshC AI-2E_transport PF01594.14 214388.1_49823001_3 - 0.017 14.1 3.4 3.6 6.5 0.1 4.1 1 1 3 5 5 5 0 AI-2E family transporter Gp49 PF05973.12 214388.1_49823001_3 - 0.028 14.4 6.0 7.1 6.7 0.1 3.9 3 1 1 4 4 3 0 Phage derived protein Gp49-like (DUF891) Phasin PF05597.9 214388.1_49823001_3 - 0.032 14.1 18.6 3.7 7.4 1.7 4.8 1 1 5 6 6 6 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF3538 PF12057.6 214388.1_49823001_3 - 0.034 13.7 6.6 1.3 8.6 0.1 4.2 3 1 1 4 4 4 0 Domain of unknown function (DUF3538) Apo-CIII PF05778.10 214388.1_49823001_3 - 0.04 13.4 0.3 0.11 12.0 0.3 1.8 1 0 0 1 1 1 0 Apolipoprotein CIII (Apo-CIII) DUF668 PF05003.10 214388.1_49823001_3 - 0.058 13.7 8.0 3.6 7.9 0.3 4.8 2 1 1 4 4 4 0 Protein of unknown function (DUF668) GCN5L1 PF06320.11 214388.1_49823001_3 - 0.09 12.8 13.0 0.24 11.4 0.1 4.2 2 1 3 5 5 5 0 GCN5-like protein 1 (GCN5L1) ZYG-11_interact PF05884.10 214388.1_49823001_3 - 0.11 11.8 9.1 3.4 6.9 1.1 3.9 1 1 2 3 3 3 0 Interactor of ZYG-11 REF PF05755.10 214388.1_49823001_3 - 0.12 12.0 3.5 6.1 6.5 1.1 3.4 1 1 2 3 3 3 0 Rubber elongation factor protein (REF) Toxin_trans PF07952.10 214388.1_49823001_3 - 0.17 10.8 5.4 1.1 8.1 0.5 2.8 2 1 1 3 3 3 0 Clostridium neurotoxin, Translocation domain VirE PF05272.9 214388.1_49823001_3 - 0.23 11.1 5.6 13 5.3 0.1 3.6 3 1 1 4 4 4 0 Virulence-associated protein E Fzo_mitofusin PF04799.11 214388.1_49823001_3 - 0.28 10.6 20.6 2.1 7.7 0.5 5.0 1 1 4 6 6 6 0 fzo-like conserved region Phage_Mu_Gam PF07352.10 214388.1_49823001_3 - 0.47 10.2 21.4 0.69 9.7 1.3 4.9 1 1 4 5 5 5 0 Bacteriophage Mu Gam like protein ApoC-I PF04691.10 214388.1_49823001_3 - 0.53 10.1 0.1 0.53 10.1 0.1 5.3 4 2 3 7 7 7 0 Apolipoprotein C-I (ApoC-1) WXG100 PF06013.10 214388.1_49823001_3 - 0.76 9.9 9.8 1.3 9.1 0.0 4.7 2 2 1 4 4 4 0 Proteins of 100 residues with WXG DUF4407 PF14362.4 214388.1_49823001_3 - 0.84 8.8 17.8 1.9 7.7 14.5 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Uso1_p115_C PF04871.11 214388.1_49823001_3 - 1.1 9.5 29.1 0.56 10.5 9.6 3.8 1 1 3 4 4 4 0 Uso1 / p115 like vesicle tethering protein, C terminal region Mit_KHE1 PF10173.7 214388.1_49823001_3 - 1.3 8.9 7.7 20 5.1 0.3 3.4 1 1 1 3 3 3 0 Mitochondrial K+-H+ exchange-related ALS2CR8 PF15299.4 214388.1_49823001_3 - 2.6 7.7 5.1 21 4.8 5.2 2.4 1 1 0 1 1 1 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 DUF3947 PF13135.4 214388.1_49823001_3 - 3 8.0 5.1 0.93 9.6 0.1 2.8 4 0 0 4 4 1 0 Protein of unknown function (DUF3947) DDHD PF02862.15 214388.1_49823001_3 - 3.2 7.7 7.3 0.89 9.5 3.1 2.2 1 1 1 2 2 2 0 DDHD domain Ku_C PF03730.12 214388.1_49823001_3 - 3.8 8.1 16.6 46 4.7 6.4 4.8 2 2 1 3 3 3 0 Ku70/Ku80 C-terminal arm MbeB_N PF04837.10 214388.1_49823001_3 - 4.3 7.6 16.7 0.77 10.0 0.3 4.5 5 0 0 5 5 3 0 MbeB-like, N-term conserved region EAP30 PF04157.14 214388.1_49823001_3 - 4.5 6.3 15.4 0.29 10.3 1.0 3.7 1 1 1 3 3 3 0 EAP30/Vps36 family TCTP PF00838.15 214388.1_49823001_3 - 5.6 7.1 6.6 16 5.5 0.2 3.1 2 1 0 3 3 3 0 Translationally controlled tumour protein DUF2205 PF10224.7 214388.1_49823001_3 - 6 6.8 32.4 1.9 8.4 1.1 7.4 3 2 5 8 8 8 0 Predicted coiled-coil protein (DUF2205) F_actin_bind PF08919.8 214388.1_49823001_3 - 7.8 6.5 10.8 13 5.7 0.5 4.0 2 1 3 5 5 5 0 F-actin binding HD_4 PF13328.4 214388.1_49823001_3 - 8.5 6.0 8.4 11 5.7 0.6 3.7 2 1 1 4 4 3 0 HD domain PDGF PF00341.15 001025110.1_39521001_1 - 1.5e-27 95.6 5.8 2.1e-27 95.1 5.8 1.2 1 0 0 1 1 1 1 PDGF/VEGF domain DUF779 PF05610.9 001025110.1_39521001_1 - 0.12 12.5 0.3 0.23 11.5 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF779) FAM221 PF14753.4 001025771.2_45723001_3 - 6.4e-96 319.5 4.6 8.2e-96 319.1 4.6 1.1 1 0 0 1 1 1 1 Protein FAM221A/B HCO3_cotransp PF00955.19 001082005.1_37927001_1 - 8e-207 688.0 0.0 9.5e-207 687.7 0.0 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 001082005.1_37927001_1 - 3.2e-55 187.7 0.0 9.3e-40 137.0 0.0 2.2 1 1 1 2 2 2 2 Band 3 cytoplasmic domain zf-RING_2 PF13639.4 001024795.1_45724001_1 - 1.4e-13 50.7 6.3 3.5e-13 49.5 6.3 1.7 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.5 001024795.1_45724001_1 - 1.2e-08 34.9 5.6 1.2e-08 34.9 5.6 1.9 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.4 001024795.1_45724001_1 - 1.2e-08 34.5 5.6 2.6e-08 33.4 5.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001024795.1_45724001_1 - 2.2e-08 33.7 4.9 4.2e-08 32.8 4.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 001024795.1_45724001_1 - 2.7e-08 33.2 3.4 2.7e-08 33.2 3.4 1.8 2 0 0 2 2 1 1 RING-like zinc finger zf-C3HC4_3 PF13920.4 001024795.1_45724001_1 - 4.9e-07 29.4 3.6 1.1e-06 28.3 3.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001024795.1_45724001_1 - 5.8e-07 29.2 3.9 1.2e-06 28.2 3.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 001024795.1_45724001_1 - 6.6e-05 22.7 2.7 0.00016 21.5 2.7 1.7 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.4 001024795.1_45724001_1 - 0.00034 20.3 4.5 0.00083 19.0 4.5 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.5 001024795.1_45724001_1 - 0.00041 20.2 1.5 0.001 18.9 1.5 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.3 001024795.1_45724001_1 - 0.06 12.9 4.5 0.13 11.8 4.5 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3H2C3 PF17122.3 001024795.1_45724001_1 - 0.11 12.4 2.8 0.32 10.9 2.8 1.8 1 0 0 1 1 1 0 Zinc-finger zf-RING-like PF08746.9 001024795.1_45724001_1 - 0.13 12.5 2.0 0.36 11.1 2.0 1.7 1 0 0 1 1 1 0 RING-like domain RINGv PF12906.5 001024795.1_45724001_1 - 0.27 11.2 5.4 0.82 9.7 5.4 1.9 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.6 001024795.1_45724001_1 - 0.49 10.5 4.9 1.6 8.9 4.9 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.4 001024795.1_45724001_1 - 0.81 9.3 4.8 2.6 7.7 4.8 1.9 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zinc_ribbon_16 PF17034.3 001024795.1_45724001_1 - 1 9.5 5.5 1.2 9.2 1.8 2.2 2 0 0 2 2 2 0 Zinc-ribbon like family Transketolase_N PF00456.19 001009097.1_39725001_3 - 1.3e-43 149.2 0.0 2.4e-43 148.2 0.0 1.4 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.22 001009097.1_39725001_3 - 1e-41 142.4 0.0 2.1e-41 141.4 0.0 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.18 001009097.1_39725001_3 - 2.1e-31 108.2 0.2 4.1e-31 107.3 0.2 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain E1_dh PF00676.18 001009097.1_39725001_3 - 1.3e-08 34.0 0.0 2.3e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.4 001009097.1_39725001_3 - 5e-06 25.8 0.0 0.00019 20.6 0.0 2.6 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.19 001009097.1_39725001_3 - 7.2e-05 22.5 0.1 0.001 18.7 0.1 2.6 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain XFP_N PF09364.8 001009097.1_39725001_3 - 0.0015 17.3 0.0 0.0025 16.5 0.0 1.3 1 0 0 1 1 1 1 XFP N-terminal domain Alba PF01918.19 001009097.1_39725001_3 - 0.035 13.8 0.6 0.088 12.5 0.1 2.0 2 0 0 2 2 2 0 Alba Ras PF00071.20 001101702.1_37922001_1 - 3.3e-63 212.0 0.1 4e-63 211.7 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001101702.1_37922001_1 - 2.2e-33 114.9 0.1 6.2e-33 113.5 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001101702.1_37922001_1 - 2.9e-13 49.5 0.0 3.8e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001101702.1_37922001_1 - 3.5e-05 23.7 0.0 7.8e-05 22.6 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001101702.1_37922001_1 - 0.00017 20.9 0.0 0.00025 20.3 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001101702.1_37922001_1 - 0.00025 20.5 0.2 0.0014 18.1 0.2 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001101702.1_37922001_1 - 0.00041 20.1 0.2 0.25 11.1 0.0 2.3 1 1 0 2 2 2 2 Protein of unknown function, DUF258 AAA_22 PF13401.4 001101702.1_37922001_1 - 0.029 14.5 0.1 0.19 11.9 0.1 2.3 1 1 1 2 2 2 0 AAA domain DAP3 PF10236.7 001101702.1_37922001_1 - 0.067 12.2 0.1 0.14 11.2 0.0 1.5 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_24 PF13479.4 001101702.1_37922001_1 - 0.1 12.2 0.1 0.13 11.8 0.1 1.4 1 1 0 1 1 1 0 AAA domain LURAP PF14854.4 001011711.1_45723001_2 - 0.001 18.9 0.0 0.002 17.9 0.0 1.4 1 0 0 1 1 1 1 Leucine rich adaptor protein DHHA1 PF02272.17 001011711.1_45723001_2 - 0.11 12.4 1.2 0.23 11.4 1.2 1.5 1 0 0 1 1 1 0 DHHA1 domain AAA PF00004.27 213749.1_49825001_3 - 1.2e-39 135.6 0.0 3e-39 134.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.8 213749.1_49825001_3 - 2.1e-06 27.5 0.0 4.9e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.10 213749.1_49825001_3 - 4e-06 26.1 0.0 1.2e-05 24.6 0.0 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.12 213749.1_49825001_3 - 0.00011 22.1 0.3 0.001 19.0 0.3 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.4 213749.1_49825001_3 - 0.00026 21.1 0.2 0.025 14.7 0.1 3.2 3 1 0 3 3 3 1 AAA domain TniB PF05621.9 213749.1_49825001_3 - 0.00047 19.3 0.2 1.5 7.8 0.0 3.0 1 1 1 2 2 2 2 Bacterial TniB protein AAA_2 PF07724.12 213749.1_49825001_3 - 0.00069 19.6 0.0 0.0018 18.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.11 213749.1_49825001_3 - 0.00087 18.2 0.1 0.0021 17.0 0.0 1.5 1 1 0 1 1 1 1 TIP49 C-terminus AAA_14 PF13173.4 213749.1_49825001_3 - 0.00095 19.1 0.0 0.079 12.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain MIT PF04212.16 213749.1_49825001_3 - 0.0033 17.3 0.2 0.0083 16.1 0.2 1.7 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Mg_chelatase PF01078.19 213749.1_49825001_3 - 0.0043 16.3 0.4 0.012 14.8 0.4 1.7 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.4 213749.1_49825001_3 - 0.01 16.1 1.0 0.099 12.9 0.4 2.9 2 1 1 3 3 3 0 AAA ATPase domain AAA_18 PF13238.4 213749.1_49825001_3 - 0.016 15.6 0.0 0.11 12.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.15 213749.1_49825001_3 - 0.018 14.7 0.0 0.033 13.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF815 PF05673.11 213749.1_49825001_3 - 0.019 14.0 0.0 0.036 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_24 PF13479.4 213749.1_49825001_3 - 0.022 14.4 0.0 0.044 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain CEND1 PF15677.3 213749.1_49825001_3 - 0.024 15.1 0.4 0.024 15.1 0.4 1.7 2 0 0 2 2 1 0 Cell cycle exit and neuronal differentiation protein 1 AAA_25 PF13481.4 213749.1_49825001_3 - 0.089 12.2 0.3 1.5 8.2 0.0 2.5 3 0 0 3 3 3 0 AAA domain DUF4368 PF14287.4 213749.1_49825001_3 - 0.11 12.7 0.0 0.34 11.1 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4368) zf-HC5HC2H PF13771.4 001014235.1_45723001_2 - 1.7e-19 69.7 3.3 1.7e-19 69.7 3.3 2.6 3 0 0 3 3 3 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.4 001014235.1_45723001_2 - 1e-07 31.9 5.5 3.6e-07 30.2 5.3 2.1 1 1 0 1 1 1 1 PHD-zinc-finger like domain EF-hand_1 PF00036.30 001004447.1_45725001_1 - 6.7e-05 22.0 0.1 0.00012 21.3 0.1 1.4 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.4 001004447.1_45725001_1 - 9.4e-05 22.0 0.0 0.00016 21.3 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 001004447.1_45725001_1 - 0.00048 19.7 0.3 0.023 14.5 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.4 001004447.1_45725001_1 - 0.002 18.4 0.0 0.0037 17.6 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.4 001004447.1_45725001_1 - 0.034 13.5 0.1 0.061 12.7 0.1 1.4 1 0 0 1 1 1 0 EF hand EF-hand_4 PF12763.5 001004447.1_45725001_1 - 0.19 11.6 0.0 0.48 10.3 0.0 1.6 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand SKI PF01202.20 001037362.1_45723001_2 - 2e-11 44.1 0.0 3.5e-11 43.3 0.0 1.4 1 1 0 1 1 1 1 Shikimate kinase AAA_33 PF13671.4 001037362.1_45723001_2 - 0.00039 20.4 0.0 0.00053 20.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 001037362.1_45723001_2 - 0.00073 19.9 0.1 0.0029 18.0 0.1 2.0 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.16 001037362.1_45723001_2 - 0.0059 16.2 0.0 0.0083 15.8 0.0 1.1 1 0 0 1 1 1 1 Cytidylate kinase AAA_22 PF13401.4 001037362.1_45723001_2 - 0.013 15.7 0.0 0.021 14.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.18 001037362.1_45723001_2 - 0.014 15.2 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase Cytidylate_kin2 PF13189.4 001037362.1_45723001_2 - 0.016 15.3 0.0 0.026 14.5 0.0 1.2 1 0 0 1 1 1 0 Cytidylate kinase-like family dNK PF01712.17 001037362.1_45723001_2 - 0.028 14.1 0.0 0.047 13.4 0.0 1.4 1 0 0 1 1 1 0 Deoxynucleoside kinase AAA_16 PF13191.4 001037362.1_45723001_2 - 0.037 14.3 0.0 0.049 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.4 001037362.1_45723001_2 - 0.038 13.6 1.1 0.055 13.1 0.2 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_17 PF13207.4 001037362.1_45723001_2 - 0.083 13.2 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.7 001037362.1_45723001_2 - 0.14 11.2 0.0 0.19 10.8 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Sulfotransfer_1 PF00685.25 001082210.2_37923001_3 - 1.1e-81 274.1 1.6 1.4e-81 273.8 1.6 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 001082210.2_37923001_3 - 8.3e-08 32.7 0.1 0.0009 19.5 0.0 2.4 2 1 1 3 3 3 2 Sulfotransferase family Gp_dh_C PF02800.18 001082210.2_37923001_3 - 0.092 12.2 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain DUF4782 PF16016.3 001131897.2_43528001_1 - 4.5e-34 117.9 0.5 9.3e-34 116.9 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4782) GRAM PF02893.18 001131897.2_43528001_1 - 1.9e-25 88.8 0.1 3.6e-25 87.9 0.1 1.5 1 0 0 1 1 1 1 GRAM domain TarH PF02203.13 001131897.2_43528001_1 - 0.011 15.6 1.7 0.017 14.9 1.7 1.3 1 0 0 1 1 1 0 Tar ligand binding domain homologue TB2_DP1_HVA22 PF03134.17 001133746.1_43527001_3 - 1.3e-29 101.8 2.6 2.4e-29 101.0 2.6 1.5 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Phage_holin_3_6 PF07332.9 001133746.1_43527001_3 - 0.082 12.8 0.2 0.15 12.0 0.2 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Ras PF00071.20 001131162.1_43524001_3 - 3.9e-38 130.5 0.0 5.3e-38 130.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001131162.1_43524001_3 - 1.2e-25 89.9 0.0 1.9e-25 89.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001131162.1_43524001_3 - 4e-11 42.5 0.0 5.9e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001131162.1_43524001_3 - 0.00014 21.2 0.0 0.00019 20.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.18 001131162.1_43524001_3 - 0.094 11.7 0.3 0.5 9.3 0.1 1.9 1 1 1 2 2 2 0 G-protein alpha subunit W2 PF02020.16 001132841.1_43524001_3 - 2.8e-22 78.5 3.4 8.3e-20 70.6 2.0 2.8 2 0 0 2 2 2 2 eIF4-gamma/eIF5/eIF2-epsilon EF-hand_7 PF13499.4 001134306.1_39522001_1 - 4.6e-29 100.6 4.4 5.1e-18 65.2 0.1 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.30 001134306.1_39522001_1 - 1.4e-27 93.0 4.9 2.8e-07 29.5 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 001134306.1_39522001_1 - 5.7e-24 81.8 3.9 5.2e-07 29.0 0.1 4.4 4 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.4 001134306.1_39522001_1 - 3.9e-23 79.7 2.6 2.6e-07 29.7 0.3 4.4 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.4 001134306.1_39522001_1 - 3e-19 68.4 7.0 3.9e-08 32.8 0.2 3.8 3 2 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 001134306.1_39522001_1 - 1.6e-07 31.5 0.2 0.0016 18.6 0.1 3.3 2 2 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 001134306.1_39522001_1 - 2.9e-06 27.0 0.8 0.15 11.9 0.0 3.3 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.4 001134306.1_39522001_1 - 0.0023 17.6 0.1 3.8 7.3 0.1 3.0 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.4 001134306.1_39522001_1 - 0.0024 18.0 0.1 4.5 7.5 0.0 3.2 2 1 1 3 3 3 1 EF-hand domain Ras PF00071.20 001123176.1_49822001_1 - 7.6e-41 139.3 0.0 9e-41 139.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001123176.1_49822001_1 - 5.9e-27 94.2 0.0 8.4e-27 93.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001123176.1_49822001_1 - 2e-09 37.0 0.0 2.6e-09 36.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001123176.1_49822001_1 - 3.5e-06 26.4 0.0 4.3e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001123176.1_49822001_1 - 0.00057 19.8 0.0 0.00082 19.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.4 001123176.1_49822001_1 - 0.0013 18.8 0.0 0.0052 16.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain GTP_EFTU PF00009.25 001123176.1_49822001_1 - 0.0015 18.0 0.0 0.038 13.4 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.7 001123176.1_49822001_1 - 0.0034 17.0 0.0 0.33 10.6 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation DLIC PF05783.9 001123176.1_49822001_1 - 0.012 14.3 0.0 1.2 7.8 0.0 2.1 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) ATP_bind_1 PF03029.15 001123176.1_49822001_1 - 0.017 14.8 0.0 1.3 8.6 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein TsaE PF02367.15 001123176.1_49822001_1 - 0.034 14.0 0.0 0.063 13.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.4 001123176.1_49822001_1 - 0.044 14.0 0.0 0.072 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Sigma54_activat PF00158.24 001123176.1_49822001_1 - 0.054 13.1 0.0 0.09 12.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain TniB PF05621.9 001123176.1_49822001_1 - 0.1 11.6 0.0 0.25 10.4 0.0 1.5 1 1 1 2 2 2 0 Bacterial TniB protein AAA_24 PF13479.4 001123176.1_49822001_1 - 0.13 11.9 0.0 0.3 10.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain Sulfotransfer_1 PF00685.25 001172893.1_09923001_3 - 2.8e-80 269.5 0.1 3.6e-80 269.2 0.1 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 001172893.1_09923001_3 - 1.3e-10 41.9 0.0 1e-09 39.0 0.0 2.0 1 1 1 2 2 2 1 Sulfotransferase family Mnd1 PF03962.13 001143777.1_32927001_2 - 0.02 14.7 0.5 0.02 14.7 0.5 1.9 2 0 0 2 2 2 0 Mnd1 family Tmemb_cc2 PF10267.7 001143777.1_32927001_2 - 0.35 9.8 4.2 3.3 6.6 4.2 2.1 1 1 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein SlyX PF04102.10 001143777.1_32927001_2 - 8.3 7.0 7.5 10 6.7 0.2 3.4 2 1 1 3 3 3 0 SlyX HIN PF02760.13 001131692.1_43527001_2 - 1.2e-146 483.7 15.6 2.9e-73 244.9 3.9 2.6 2 0 0 2 2 2 2 HIN-200/IF120x domain PYRIN PF02758.14 001131692.1_43527001_2 - 1.5e-12 47.4 0.5 3e-12 46.4 0.5 1.6 1 0 0 1 1 1 1 PAAD/DAPIN/Pyrin domain tRNA_anti-codon PF01336.23 001131692.1_43527001_2 - 0.0014 18.5 0.2 0.58 10.1 0.0 3.5 3 0 0 3 3 3 1 OB-fold nucleic acid binding domain Img2 PF05046.12 001132568.1_43525001_1 - 2.9e-27 94.6 0.0 4.4e-27 94.1 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) Synaptobrevin PF00957.19 001131329.2_43522001_3 - 1.4e-31 108.0 1.7 1.8e-31 107.6 1.7 1.2 1 0 0 1 1 1 1 Synaptobrevin Ferlin_C PF16165.3 001131329.2_43522001_3 - 0.0025 17.6 0.2 0.0046 16.8 0.2 1.5 1 0 0 1 1 1 1 Ferlin C-terminus DUF912 PF06024.10 001131329.2_43522001_3 - 0.017 15.3 0.3 0.025 14.7 0.3 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) MCU PF04678.11 001131329.2_43522001_3 - 0.029 14.4 0.0 0.039 14.0 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter TMCO5 PF14992.4 001131329.2_43522001_3 - 0.053 13.0 0.2 0.071 12.5 0.2 1.1 1 0 0 1 1 1 0 TMCO5 family Baculo_F PF12259.6 001131329.2_43522001_3 - 0.075 11.4 0.9 0.092 11.1 0.9 1.1 1 0 0 1 1 1 0 Baculovirus F protein Sec20 PF03908.11 001131329.2_43522001_3 - 0.087 12.6 0.1 0.087 12.6 0.1 1.6 2 0 0 2 2 1 0 Sec20 Prominin PF05478.9 001131329.2_43522001_3 - 0.11 10.2 1.6 0.27 9.0 1.7 1.5 1 1 0 1 1 1 0 Prominin ODV-E18 PF10717.7 001131329.2_43522001_3 - 0.14 11.9 0.1 0.24 11.1 0.1 1.4 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Baculo_11_kDa PF06143.9 001131329.2_43522001_3 - 0.36 10.3 2.2 0.63 9.5 2.2 1.3 1 0 0 1 1 1 0 Baculovirus 11 kDa family Sigma_reg_N PF13800.4 001131329.2_43522001_3 - 0.39 10.9 3.3 0.66 10.2 3.3 1.3 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Ras PF00071.20 001132915.1_43526001_1 - 8e-44 149.0 0.0 1e-43 148.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001132915.1_43526001_1 - 3.9e-30 104.4 0.0 5.6e-30 103.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001132915.1_43526001_1 - 1.1e-13 50.9 0.0 2e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001132915.1_43526001_1 - 0.0045 16.3 0.0 0.0073 15.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.10 001132915.1_43526001_1 - 0.0061 15.8 0.0 0.0091 15.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001132915.1_43526001_1 - 0.014 15.4 0.0 0.02 14.8 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase PduV-EutP PF10662.7 001132915.1_43526001_1 - 0.031 13.9 0.0 0.057 13.0 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.4 001132915.1_43526001_1 - 0.1 12.8 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain TniB PF05621.9 001132915.1_43526001_1 - 0.15 11.1 0.0 0.26 10.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein EF-hand_7 PF13499.4 001164713.1_39522001_2 - 5.1e-11 42.8 3.7 1.4e-10 41.4 3.7 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 001164713.1_39522001_2 - 6.9e-10 37.6 2.5 0.00014 21.1 0.4 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 001164713.1_39522001_2 - 3.9e-09 35.6 3.3 1.1e-05 24.8 0.6 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.4 001164713.1_39522001_2 - 7.7e-07 28.7 3.0 2.6e-06 27.0 3.0 1.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.4 001164713.1_39522001_2 - 3.1e-05 23.1 1.3 0.055 12.9 0.4 2.5 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.7 001164713.1_39522001_2 - 0.019 15.2 0.7 0.055 13.7 0.7 1.7 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 001164713.1_39522001_2 - 0.035 13.9 1.3 0.15 11.9 0.5 2.0 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand RAG2 PF03089.12 001128481.1_49824001_1 - 2.9e-191 634.7 0.1 3.5e-191 634.4 0.1 1.1 1 0 0 1 1 1 1 Recombination activating protein 2 RAG2_PHD PF13341.4 001128481.1_49824001_1 - 6.2e-47 157.4 4.4 1.1e-46 156.5 4.4 1.5 1 0 0 1 1 1 1 RAG2 PHD domain Kelch_5 PF13854.4 001128481.1_49824001_1 - 3.2e-05 23.7 0.7 0.56 10.1 0.0 4.0 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.4 001128481.1_49824001_1 - 0.0003 20.8 0.0 0.017 15.2 0.0 3.4 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_4 PF13418.4 001128481.1_49824001_1 - 0.0037 17.1 0.1 84 3.1 0.0 4.6 4 0 0 4 4 4 0 Galactose oxidase, central domain CAF1C_H4-bd PF12265.6 001128481.1_49824001_1 - 0.027 14.6 0.0 3.9 7.7 0.0 2.6 2 0 0 2 2 2 0 Histone-binding protein RBBP4 or subunit C of CAF1 complex PHD PF00628.27 001128481.1_49824001_1 - 0.6 9.9 7.5 0.077 12.8 1.1 2.4 2 0 0 2 2 2 0 PHD-finger Ints3 PF10189.7 001131437.1_43529001_2 - 2.5e-106 353.8 0.0 4.8e-106 352.9 0.0 1.5 1 0 0 1 1 1 1 Integrator complex subunit 3 SKA1 PF07160.10 001131437.1_43529001_2 - 1.9 8.1 7.8 2.9 7.5 4.6 2.4 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 7tm_1 PF00001.19 001173046.1_09923001_1 - 3e-50 170.8 24.1 4.6e-50 170.2 24.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001173046.1_09923001_1 - 3.2e-08 33.2 23.7 5.2e-08 32.4 23.7 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001173046.1_09923001_1 - 0.086 12.0 31.3 0.43 9.7 30.0 2.2 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx PXA PF02194.13 146774.1_26228120_1 - 1.2e-36 125.9 1.8 2.8e-36 124.7 1.4 1.8 2 0 0 2 2 2 1 PXA domain PX PF00787.22 146774.1_26228120_1 - 2.6e-20 72.4 1.6 2.6e-20 72.4 1.6 2.9 3 0 0 3 3 3 1 PX domain RGS PF00615.17 146774.1_26228120_1 - 1.6e-11 44.3 2.4 1.6e-11 44.3 2.4 2.0 2 0 0 2 2 2 1 Regulator of G protein signaling domain Nexin_C PF08628.10 146774.1_26228120_1 - 8.3e-08 32.7 0.0 2.4e-07 31.3 0.0 1.8 2 0 0 2 2 2 1 Sorting nexin C terminal PXA PF02194.13 146779.1_26229120_1 - 1.5e-36 125.6 1.9 3.1e-36 124.6 1.4 1.8 2 0 0 2 2 2 1 PXA domain PX PF00787.22 146779.1_26229120_1 - 2.8e-20 72.2 1.6 2.8e-20 72.2 1.6 2.9 3 0 0 3 3 3 1 PX domain RGS PF00615.17 146779.1_26229120_1 - 1.8e-11 44.2 2.4 1.8e-11 44.2 2.4 2.0 2 0 0 2 2 2 1 Regulator of G protein signaling domain Nexin_C PF08628.10 146779.1_26229120_1 - 8.9e-08 32.6 0.0 2.6e-07 31.1 0.0 1.8 2 0 0 2 2 2 1 Sorting nexin C terminal Aminotran_1_2 PF00155.19 001098541.2_39725001_3 - 3e-92 309.5 0.0 3.5e-92 309.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II SVA PF05326.9 001171116.1_37921001_1 - 1.3e-53 180.1 1.0 1.5e-53 179.9 1.0 1.0 1 0 0 1 1 1 1 Seminal vesicle autoantigen (SVA) 7tm_1 PF00001.19 001123074.1_49823001_1 - 8.4e-80 267.7 5.0 1e-79 267.5 5.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001123074.1_49823001_1 - 6.7e-16 58.3 0.0 1.2e-15 57.5 0.0 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 001123074.1_49823001_1 - 3.5e-07 29.7 0.3 9.6e-07 28.3 0.1 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 001123074.1_49823001_1 - 2.7e-06 27.2 8.8 3e-05 23.7 6.6 2.3 2 1 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001123074.1_49823001_1 - 6.8e-06 25.5 6.2 3e-05 23.4 6.4 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx PRIMA1 PF16101.3 001123074.1_49823001_1 - 6.5 6.7 10.0 7.4 6.5 0.4 3.0 3 0 0 3 3 3 0 Proline-rich membrane anchor 1 Gly_acyl_tr_N PF06021.9 134330.2_45724001_2 - 1.2e-82 276.8 0.8 1.5e-82 276.4 0.8 1.1 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase Gly_acyl_tr_C PF08444.8 134330.2_45724001_2 - 1.1e-45 153.7 1.1 2.5e-45 152.5 1.1 1.6 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region ABM PF03992.14 001133547.1_43527001_3 - 4.4e-10 39.4 0.1 7.1e-10 38.7 0.1 1.3 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase EF-hand_1 PF00036.30 001133547.1_43527001_3 - 6.4e-08 31.5 3.2 0.00013 21.1 0.8 3.0 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.4 001133547.1_43527001_3 - 5e-07 29.3 1.2 0.0015 18.1 0.1 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.4 001133547.1_43527001_3 - 6.3e-07 29.7 0.3 0.015 15.6 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 001133547.1_43527001_3 - 3.9e-06 26.2 2.5 0.057 13.3 0.3 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.4 001133547.1_43527001_3 - 3.6e-05 22.9 2.2 0.00014 21.1 0.7 2.4 1 1 1 2 2 2 1 EF hand MRP-L28 PF09812.7 001133547.1_43527001_3 - 1.9 8.5 6.3 0.15 12.1 0.7 1.9 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L28 E1_dh PF00676.18 001098564.1_39724001_3 - 2.7e-114 381.0 0.0 3.9e-114 380.5 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.19 001098564.1_39724001_3 - 0.00056 19.6 0.2 0.0023 17.6 0.2 2.0 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.4 001098564.1_39724001_3 - 0.0032 16.6 0.0 0.0071 15.5 0.0 1.5 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase BCIP PF13862.4 001098564.1_39724001_3 - 4.9 6.7 8.0 39 3.8 0.0 2.1 2 0 0 2 2 2 0 p21-C-terminal region-binding protein Prefoldin_2 PF01920.18 001133913.1_43523001_3 - 1.5e-19 69.8 15.1 1.5e-19 69.8 15.1 2.2 2 0 0 2 2 2 1 Prefoldin subunit Rot1 PF10681.7 001133913.1_43523001_3 - 0.8 9.1 4.3 1.6 8.1 4.3 1.4 1 0 0 1 1 1 0 Chaperone for protein-folding within the ER, fungal Ribosomal_L44 PF00935.17 001168904.1_40421001_1 - 2e-39 133.8 7.5 2.7e-39 133.4 7.5 1.2 1 0 0 1 1 1 1 Ribosomal protein L44 MA3 PF02847.15 001132308.1_43527001_1 - 3.4e-24 84.9 1.4 3.4e-24 84.9 1.4 2.1 2 0 0 2 2 2 1 MA3 domain Cnd1 PF12717.5 001132308.1_43527001_1 - 0.094 12.6 0.3 0.46 10.4 0.0 2.3 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 SSP160 PF06933.9 001132308.1_43527001_1 - 2.6 6.0 12.6 3.7 5.5 12.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 TRM PF02005.14 001283794.1_29526001_3 - 5.9e-66 223.0 2.8 1.6e-55 188.7 0.5 3.2 2 1 1 3 3 3 2 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.14 001283794.1_29526001_3 - 0.00042 20.0 0.1 0.00094 18.9 0.1 1.5 1 1 0 1 1 1 1 Met-10+ like-protein DUF4604 PF15377.4 001283794.1_29526001_3 - 0.0029 18.0 10.7 0.0071 16.7 10.7 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) Methyltransf_25 PF13649.4 001283794.1_29526001_3 - 0.0031 18.1 0.3 1.6 9.4 0.0 3.8 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.4 001283794.1_29526001_3 - 0.0088 15.7 0.2 0.043 13.5 0.1 2.3 2 1 0 2 2 2 1 Methyltransferase domain zf-C2H2_4 PF13894.4 001283794.1_29526001_3 - 0.62 10.9 14.1 1.1 10.1 0.4 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger Connexin PF00029.17 001283794.1_29526001_3 - 4.4 6.9 7.1 8 6.0 7.1 1.5 1 0 0 1 1 1 0 Connexin Lysyl_oxidase PF01186.15 001206403.1_49824001_2 - 6.6e-93 309.9 4.1 8.3e-93 309.6 4.1 1.1 1 0 0 1 1 1 1 Lysyl oxidase CARDB PF07705.9 001206403.1_49824001_2 - 0.048 13.8 0.0 0.16 12.1 0.0 1.8 2 0 0 2 2 2 0 CARDB 7tm_1 PF00001.19 001289866.1_29626001_3 - 1e-78 264.1 0.9 1e-78 264.1 0.9 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001289866.1_29626001_3 - 5.8e-16 58.5 0.2 2.1e-15 56.7 0.0 2.0 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001289866.1_29626001_3 - 8.6e-07 28.4 6.1 8.6e-07 28.4 6.1 2.2 3 0 0 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001289866.1_29626001_3 - 1.2e-06 28.3 5.9 4.7e-06 26.4 3.7 2.2 2 0 0 2 2 2 1 Olfactory receptor ATP-grasp_2 PF08442.8 001283436.1_29525001_1 - 1.7e-73 246.4 0.7 2.8e-73 245.7 0.7 1.3 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.17 001283436.1_29525001_1 - 5e-26 91.2 2.2 7.8e-26 90.6 2.2 1.3 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.4 001283436.1_29525001_1 - 8.5e-12 44.9 0.1 1.7e-11 43.9 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.17 001283436.1_29525001_1 - 0.0083 15.8 0.8 0.023 14.3 0.8 1.7 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain CPSase_L_D2 PF02786.15 001283436.1_29525001_1 - 0.014 14.8 1.4 0.045 13.1 0.2 2.1 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, ATP binding domain FWWh PF14922.4 029455.3_32924001_1 - 1.6e-49 167.5 5.8 1.6e-49 167.5 5.8 2.1 3 0 0 3 3 3 1 Protein of unknown function Herpes_UL25 PF01499.14 029455.3_32924001_1 - 0.068 11.5 0.4 0.098 11.0 0.4 1.2 1 0 0 1 1 1 0 Herpesvirus UL25 family Exonuc_VII_L PF02601.13 029455.3_32924001_1 - 0.11 11.9 5.6 0.25 10.8 1.1 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit Mit_ribos_Mrp51 PF11709.6 029455.3_32924001_1 - 6.5 6.1 8.9 1 8.8 1.9 2.4 3 0 0 3 3 3 0 Mitochondrial ribosomal protein subunit Allexi_40kDa PF05549.9 029455.3_32924001_1 - 7.5 5.8 7.2 2 7.7 1.7 2.5 3 0 0 3 3 3 0 Allexivirus 40kDa protein EF_assoc_2 PF08356.10 214325.2_49825001_2 - 1.2e-33 114.8 0.0 2.1e-33 114.0 0.0 1.4 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.10 214325.2_49825001_2 - 5.9e-24 83.4 0.0 3e-23 81.1 0.0 2.0 2 0 0 2 2 2 1 EF hand associated Ras PF00071.20 214325.2_49825001_2 - 4.6e-20 71.7 0.0 4.8e-17 61.9 0.0 2.8 2 1 0 2 2 2 2 Ras family Roc PF08477.11 214325.2_49825001_2 - 1.2e-10 41.5 0.0 3.4e-08 33.6 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase EF-hand_7 PF13499.4 214325.2_49825001_2 - 1.3e-06 28.7 0.0 0.0078 16.5 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair Arf PF00025.19 214325.2_49825001_2 - 9.3e-06 25.1 0.0 2.1e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family EF-hand_1 PF00036.30 214325.2_49825001_2 - 1.1e-05 24.5 0.1 0.0019 17.5 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 214325.2_49825001_2 - 8.5e-05 22.1 0.1 0.0047 16.6 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain MMR_HSR1 PF01926.21 214325.2_49825001_2 - 9.2e-05 22.4 0.0 0.08 12.9 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.4 214325.2_49825001_2 - 0.00017 21.9 0.0 0.49 10.6 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain Dynamin_N PF00350.21 214325.2_49825001_2 - 0.0023 17.9 0.2 0.47 10.3 0.0 2.2 2 0 0 2 2 2 1 Dynamin family SPARC_Ca_bdg PF10591.7 214325.2_49825001_2 - 0.0023 18.1 0.0 2.5 8.3 0.0 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region DUF258 PF03193.14 214325.2_49825001_2 - 0.0055 16.5 0.0 9.6 5.9 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function, DUF258 DUF815 PF05673.11 214325.2_49825001_2 - 0.007 15.4 0.0 0.059 12.4 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF815) ABC_tran PF00005.25 214325.2_49825001_2 - 0.0089 16.4 0.1 2.5 8.5 0.0 2.3 2 0 0 2 2 2 1 ABC transporter SRPRB PF09439.8 214325.2_49825001_2 - 0.012 14.9 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit EF-hand_5 PF13202.4 214325.2_49825001_2 - 0.014 14.8 0.0 0.037 13.4 0.0 1.8 1 0 0 1 1 1 0 EF hand AAA_14 PF13173.4 214325.2_49825001_2 - 0.023 14.6 0.0 7.2 6.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.4 214325.2_49825001_2 - 0.06 13.5 0.0 12 6.1 0.0 2.7 2 1 0 2 2 2 0 AAA domain Auts2 PF15336.4 214325.2_49825001_2 - 0.064 13.3 0.2 0.14 12.1 0.2 1.5 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein AAA_24 PF13479.4 214325.2_49825001_2 - 0.092 12.3 0.0 2.7 7.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain Ras PF00071.20 138542.2_45724001_1 - 3e-45 153.6 0.0 4e-45 153.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 138542.2_45724001_1 - 1.5e-19 70.2 0.0 2.1e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 138542.2_45724001_1 - 0.002 17.5 0.0 0.0033 16.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 138542.2_45724001_1 - 0.018 15.0 0.0 0.027 14.4 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase G-alpha PF00503.18 001283065.1_29524001_2 - 4.2e-125 417.4 1.9 5.1e-125 417.2 1.9 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 001283065.1_29524001_2 - 5.9e-17 61.5 0.1 2.2e-12 46.7 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001283065.1_29524001_2 - 8.9e-05 21.8 1.3 0.075 12.2 0.6 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.11 001283065.1_29524001_2 - 0.00051 20.1 0.2 1.4 9.1 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 001283065.1_29524001_2 - 0.021 15.1 0.0 0.035 14.3 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain EF-hand_1 PF00036.30 001285643.1_09023001_1 - 8e-21 71.9 4.1 0.00042 19.5 0.1 5.9 6 0 0 6 6 6 5 EF hand EF-hand_7 PF13499.4 001285643.1_09023001_1 - 2.1e-16 60.0 9.8 2.9e-07 30.7 0.0 5.1 3 3 1 5 5 5 5 EF-hand domain pair EF-hand_6 PF13405.4 001285643.1_09023001_1 - 1.3e-13 49.6 0.8 0.27 11.1 0.0 5.9 6 0 0 6 6 6 4 EF-hand domain EF-hand_5 PF13202.4 001285643.1_09023001_1 - 1.2e-12 46.5 0.4 0.0021 17.4 0.0 4.7 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.4 001285643.1_09023001_1 - 7.1e-09 35.2 0.5 0.00087 18.9 0.0 4.0 3 1 1 4 4 4 2 EF-hand domain pair SPARC_Ca_bdg PF10591.7 001285643.1_09023001_1 - 9.6e-05 22.5 8.3 0.093 12.9 0.2 3.5 2 1 1 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region DUF2433 PF10360.7 001285643.1_09023001_1 - 1.2 9.1 4.3 4.5 7.2 0.7 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2433) CBAH PF02275.16 001285344.1_29525001_2 - 1.6e-56 192.1 1.1 1.1e-55 189.4 1.1 1.9 1 1 0 1 1 1 1 Linear amide C-N hydrolases, choloylglycine hydrolase family NAAA-beta PF15508.4 001285344.1_29525001_2 - 1.3e-21 76.5 0.1 3.2e-21 75.2 0.1 1.7 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase AAT PF03417.14 001285344.1_29525001_2 - 0.022 14.3 0.0 0.038 13.5 0.0 1.3 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase STOP PF05217.10 001284105.1_29524001_3 - 0.0011 19.0 7.0 0.0011 19.0 7.0 3.8 4 0 0 4 4 4 1 STOP protein Rdx PF10262.7 001199929.1_08023001_3 - 2.2e-10 40.4 0.0 4.5e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 Rdx family Pyr_redox_2 PF07992.12 214154.3_49827001_1 - 9.4e-55 185.8 0.2 1.2e-54 185.4 0.2 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.20 214154.3_49827001_1 - 9.6e-28 96.5 0.0 1.6e-27 95.8 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.25 214154.3_49827001_1 - 5.8e-18 65.1 2.3 3.5e-15 56.2 0.2 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 214154.3_49827001_1 - 1.3e-14 54.0 0.2 7.2e-11 41.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 214154.3_49827001_1 - 1.5e-05 24.2 0.4 2.4e-05 23.4 0.4 1.3 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.19 214154.3_49827001_1 - 0.00044 19.5 0.0 0.03 13.5 0.0 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.5 214154.3_49827001_1 - 0.00082 18.7 0.0 0.0011 18.2 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.12 214154.3_49827001_1 - 0.0017 17.0 0.2 0.0052 15.4 0.1 1.7 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.15 214154.3_49827001_1 - 0.0027 16.8 0.5 0.0065 15.6 0.0 1.7 2 0 0 2 2 2 1 Thi4 family GIDA PF01134.20 214154.3_49827001_1 - 0.0064 15.5 0.1 0.011 14.7 0.1 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.4 214154.3_49827001_1 - 0.056 13.6 0.1 0.056 13.6 0.1 2.3 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain DAO PF01266.22 214154.3_49827001_1 - 0.12 11.8 0.4 0.23 10.9 0.1 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase Sep15_SelM PF08806.9 001257993.1_09922001_1 - 1.7e-22 79.3 0.0 2.9e-22 78.5 0.0 1.4 1 0 0 1 1 1 1 Sep15/SelM redox domain Sep15_SelM PF08806.9 001256960.1_37923001_1 - 4.3e-22 78.0 0.0 8.4e-22 77.0 0.0 1.5 1 0 0 1 1 1 1 Sep15/SelM redox domain Rdx PF10262.7 001199819.1_37929001_1 - 2.3e-09 37.2 0.0 4e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Rdx family RNA_pol_Rpc4 PF05132.12 001319597.1_29524001_1 - 0.014 15.7 20.0 0.022 15.1 20.0 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 DDHD PF02862.15 001319597.1_29524001_1 - 0.12 12.4 11.7 0.17 11.9 11.7 1.3 1 0 0 1 1 1 0 DDHD domain AAA_11 PF13086.4 001319597.1_29524001_1 - 2.3 7.8 21.5 3.7 7.1 21.5 1.4 1 0 0 1 1 1 0 AAA domain IQ PF00612.25 001319597.1_29524001_3 - 1.8e-11 42.6 19.3 8.9e-05 21.8 1.5 3.8 3 0 0 3 3 3 3 IQ calmodulin-binding motif RNA_pol_Rpc4 PF05132.12 001319597.1_29524001_3 - 0.00055 20.3 15.3 0.00055 20.3 15.3 2.0 2 0 0 2 2 2 1 RNA polymerase III RPC4 DUF2052 PF09747.7 001319597.1_29524001_3 - 0.76 9.8 23.0 4.9 7.1 18.4 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Cadherin PF00028.15 001082566.2_39729001_2 - 6.3e-79 260.4 0.0 3.6e-17 62.4 0.0 6.2 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001082566.2_39729001_2 - 5.9e-31 106.0 0.1 7e-28 96.1 0.3 3.8 4 0 0 4 4 4 1 Cadherin-like Cadherin_tail PF15974.3 001082566.2_39729001_2 - 2e-25 89.6 3.3 4.1e-25 88.5 3.3 1.5 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 001082566.2_39729001_2 - 2.5e-20 72.9 0.1 6.1e-20 71.7 0.1 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001082566.2_39729001_2 - 0.0021 17.9 3.2 9 6.2 0.1 4.7 4 1 1 5 5 5 2 Cadherin-like Casein_kappa PF00997.16 001082625.3_37922001_2 - 5.4e-70 234.5 15.7 7.2e-70 234.1 15.7 1.1 1 0 0 1 1 1 1 Kappa casein Peptidase_C1 PF00112.21 001308587.1_39523001_1 - 1.4e-65 221.4 4.1 1.7e-65 221.1 4.1 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Propeptide_C1 PF08127.11 001308587.1_39523001_1 - 7.8e-20 70.3 0.1 1.4e-19 69.5 0.1 1.5 1 0 0 1 1 1 1 Peptidase family C1 propeptide Peptidase_C1_2 PF03051.13 001308587.1_39523001_1 - 0.0018 17.0 1.0 0.056 12.1 0.2 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Cadherin PF00028.15 001082591.2_39729001_1 - 4.2e-77 254.6 0.0 4e-19 68.7 0.0 6.4 6 0 0 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 001082591.2_39729001_1 - 2.1e-63 212.4 4.7 3.6e-63 211.7 4.7 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 001082591.2_39729001_1 - 5.7e-33 112.5 1.4 2.9e-29 100.6 0.1 4.4 5 0 0 5 5 5 2 Cadherin-like Cadherin_C_2 PF16492.3 001082591.2_39729001_1 - 2.6e-06 28.0 0.1 6.9e-06 26.6 0.1 1.8 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Sulfotransfer_1 PF00685.25 001009157.3_39722001_1 - 8.3e-52 176.1 0.0 1.2e-51 175.6 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 001009157.3_39722001_1 - 7.5e-05 23.1 0.0 0.00013 22.3 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase family APS_kinase PF01583.18 001009157.3_39722001_1 - 0.16 11.7 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase zf-3CxxC PF13695.4 001129956.1_49823001_1 - 2.3e-08 34.2 15.5 3.6e-08 33.7 15.5 1.3 1 0 0 1 1 1 1 Zinc-binding domain zf-3CxxC_2 PF17180.2 001129956.1_49823001_1 - 2.2e-06 28.1 15.7 4.7e-06 27.1 15.7 1.6 1 0 0 1 1 1 1 Zinc-binding domain Cadherin PF00028.15 001082589.2_39729001_1 - 7.6e-77 253.7 0.0 1.8e-19 69.9 0.0 6.4 6 0 0 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 001082589.2_39729001_1 - 2.2e-63 212.4 4.7 3.6e-63 211.7 4.7 1.3 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 001082589.2_39729001_1 - 9.2e-32 108.6 3.5 6.6e-29 99.4 0.1 4.2 5 0 0 5 5 5 1 Cadherin-like Cadherin_3 PF16184.3 001082589.2_39729001_1 - 1.1e-06 28.5 0.9 0.13 12.2 0.2 4.2 4 0 0 4 4 4 2 Cadherin-like Cadherin_C_2 PF16492.3 001082589.2_39729001_1 - 2.7e-06 27.9 0.1 7.7e-06 26.5 0.1 1.8 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal p450 PF00067.20 001005352.3_49827001_2 - 2.3e-79 267.2 0.0 2.8e-79 266.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 CFTR_R PF14396.4 001112615.2_40429001_1 - 3.4e-101 337.1 2.3 5.7e-101 336.3 2.3 1.4 1 0 0 1 1 1 1 Cystic fibrosis TM conductance regulator (CFTR), regulator domain ABC_membrane PF00664.21 001112615.2_40429001_1 - 1.1e-91 307.2 41.4 3.9e-50 170.9 20.1 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 001112615.2_40429001_1 - 2.7e-59 199.4 0.0 3.7e-33 114.8 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 001112615.2_40429001_1 - 1.1e-07 31.4 0.0 0.017 14.4 0.0 3.5 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.4 001112615.2_40429001_1 - 1.4e-07 31.5 1.3 0.024 14.3 0.1 3.4 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 001112615.2_40429001_1 - 1.5e-06 27.6 0.5 0.00068 19.2 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain T2SSE PF00437.18 001112615.2_40429001_1 - 8.4e-06 24.9 0.1 0.063 12.2 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein DUF258 PF03193.14 001112615.2_40429001_1 - 2.8e-05 23.9 1.1 0.031 14.1 0.1 2.7 2 1 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.4 001112615.2_40429001_1 - 6.1e-05 23.3 0.0 0.29 11.4 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.15 001112615.2_40429001_1 - 0.0002 21.4 2.3 0.059 13.3 0.1 3.1 3 0 0 3 3 2 1 Domain of unknown function DUF87 Zeta_toxin PF06414.10 001112615.2_40429001_1 - 0.00042 19.5 0.3 0.14 11.4 0.1 2.7 2 0 0 2 2 2 1 Zeta toxin MMR_HSR1 PF01926.21 001112615.2_40429001_1 - 0.0006 19.8 0.0 0.22 11.5 0.0 3.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase ArgK PF03308.14 001112615.2_40429001_1 - 0.00086 18.2 0.7 0.013 14.4 0.1 2.4 2 0 0 2 2 2 1 ArgK protein NACHT PF05729.10 001112615.2_40429001_1 - 0.00088 19.1 0.8 1.4 8.7 0.1 2.7 2 0 0 2 2 2 2 NACHT domain AAA_22 PF13401.4 001112615.2_40429001_1 - 0.0022 18.2 0.8 2.6 8.2 0.0 3.2 3 0 0 3 3 2 1 AAA domain NTPase_1 PF03266.13 001112615.2_40429001_1 - 0.0053 16.6 0.3 0.26 11.0 0.0 2.8 3 0 0 3 3 3 1 NTPase Roc PF08477.11 001112615.2_40429001_1 - 0.0078 16.3 0.1 3.4 7.8 0.0 3.5 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase AAA_30 PF13604.4 001112615.2_40429001_1 - 0.013 15.1 0.0 0.69 9.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.4 001112615.2_40429001_1 - 0.013 15.7 0.1 13 5.9 0.0 3.2 2 1 0 2 2 2 0 AAA domain MobB PF03205.12 001112615.2_40429001_1 - 0.022 14.5 1.1 11 5.8 0.1 3.3 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B FtsK_SpoIIIE PF01580.16 001112615.2_40429001_1 - 0.026 13.8 0.3 4.3 6.5 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family TsaE PF02367.15 001112615.2_40429001_1 - 0.028 14.3 0.4 9.9 6.0 0.1 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.20 001112615.2_40429001_1 - 0.037 12.9 0.1 1.2 7.9 0.0 2.7 2 0 0 2 2 2 0 NB-ARC domain cobW PF02492.17 001112615.2_40429001_1 - 0.046 13.2 1.8 4.2 6.8 0.1 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.4 001112615.2_40429001_1 - 0.06 13.7 12.6 0.83 10.0 0.0 4.3 4 0 0 4 4 4 0 AAA domain AAA_24 PF13479.4 001112615.2_40429001_1 - 0.079 12.5 0.4 3.3 7.2 0.0 3.1 3 0 0 3 3 3 0 AAA domain TrwB_AAD_bind PF10412.7 001112615.2_40429001_1 - 0.11 11.2 0.4 5 5.8 0.0 2.6 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_25 PF13481.4 001112615.2_40429001_1 - 0.18 11.2 0.2 8.4 5.8 0.1 2.4 2 0 0 2 2 2 0 AAA domain Rotamase_2 PF13145.4 001112615.2_40429001_1 - 0.18 12.5 0.5 0.54 11.0 0.1 1.9 2 0 0 2 2 1 0 PPIC-type PPIASE domain DUF4791 PF16039.3 001112615.2_40429001_1 - 2.8 7.3 6.3 15 4.9 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4791) AAA_15 PF13175.4 001112615.2_40429001_1 - 8.5 5.7 8.3 11 5.4 0.0 3.8 4 1 0 4 4 4 0 AAA ATPase domain Cadherin PF00028.15 001082561.2_39729001_2 - 7.1e-83 273.1 0.3 2.6e-18 66.1 0.4 6.2 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001082561.2_39729001_2 - 1.9e-31 107.5 0.2 2.8e-28 97.4 0.0 4.0 5 0 0 5 5 5 2 Cadherin-like Cadherin_tail PF15974.3 001082561.2_39729001_2 - 1.9e-25 89.6 3.3 4e-25 88.5 3.3 1.5 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 001082561.2_39729001_2 - 4.3e-22 78.6 0.3 1.1e-21 77.3 0.3 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001082561.2_39729001_2 - 8.7e-07 28.8 4.4 3.1 7.7 0.0 5.2 4 1 1 5 5 5 4 Cadherin-like Filament PF00038.19 001199069.1_39524001_1 - 6.1e-97 324.8 29.7 7.2e-97 324.6 29.7 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001199069.1_39524001_1 - 3.7e-11 43.3 9.6 3.7e-11 43.3 9.6 2.6 2 1 0 2 2 1 1 Keratin type II head TPR_MLP1_2 PF07926.10 001199069.1_39524001_1 - 2.3e-06 27.5 25.3 5.1e-05 23.2 0.8 3.7 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein DUF4924 PF16271.3 001199069.1_39524001_1 - 0.018 15.0 0.6 0.034 14.0 0.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4924) BRE1 PF08647.9 001199069.1_39524001_1 - 0.025 14.5 0.9 0.025 14.5 0.9 3.3 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase BAT PF15915.3 001199069.1_39524001_1 - 0.033 13.9 0.5 0.068 12.9 0.5 1.5 1 0 0 1 1 1 0 GAF and HTH_10 associated domain Spc7 PF08317.9 001199069.1_39524001_1 - 0.033 12.9 23.8 0.26 10.0 11.4 2.7 1 1 0 2 2 2 0 Spc7 kinetochore protein Alanine_zipper PF11839.6 001199069.1_39524001_1 - 0.1 12.8 4.8 0.27 11.4 4.8 1.7 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein DUF1635 PF07795.9 001199069.1_39524001_1 - 0.32 10.8 4.1 0.67 9.8 4.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) CHDCT2 PF08074.9 001199069.1_39524001_1 - 0.51 10.4 6.3 3.1 7.8 0.3 2.4 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain DUF2205 PF10224.7 001199069.1_39524001_1 - 0.61 10.0 6.0 1.4 8.8 0.2 3.2 2 0 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) Spc42p PF11544.6 001199069.1_39524001_1 - 0.65 9.9 4.5 0.5 10.3 0.4 2.4 2 0 0 2 2 2 0 Spindle pole body component Spc42p Cep57_MT_bd PF06657.11 001199069.1_39524001_1 - 0.86 10.0 4.7 0.42 11.0 0.4 2.7 2 1 0 2 2 1 0 Centrosome microtubule-binding domain of Cep57 MCC-bdg_PDZ PF10506.7 001199069.1_39524001_1 - 1.4 8.9 9.0 0.67 9.9 1.3 3.6 2 2 2 4 4 4 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Tropomyosin_1 PF12718.5 001199069.1_39524001_1 - 1.9 8.4 27.0 0.019 15.0 9.2 3.3 2 1 0 3 3 3 0 Tropomyosin like SPATA1_C PF15743.3 001199069.1_39524001_1 - 3.4 7.6 15.4 0.59 10.0 0.7 3.1 3 1 0 3 3 3 0 Spermatogenesis-associated C-terminus HIP1_clath_bdg PF16515.3 001199069.1_39524001_1 - 4.6 7.8 9.7 3 8.4 4.2 2.8 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF972 PF06156.11 001199069.1_39524001_1 - 5.8 7.5 22.0 4.8 7.7 0.3 4.2 2 2 2 4 4 4 0 Protein of unknown function (DUF972) FlaC_arch PF05377.9 001199069.1_39524001_1 - 5.9 7.2 8.5 12 6.2 0.9 4.0 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) CALCOCO1 PF07888.9 001199069.1_39524001_1 - 6.8 5.0 25.2 17 3.7 25.2 1.5 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DASH_Duo1 PF08651.8 001199069.1_39524001_1 - 8.5 6.1 8.3 2.3 7.9 2.3 3.0 4 0 0 4 4 4 0 DASH complex subunit Duo1 DUF745 PF05335.11 001199069.1_39524001_1 - 9 5.9 17.2 1.1 8.8 6.4 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF745) Cadherin PF00028.15 001082570.2_39729001_2 - 1.9e-81 268.5 0.1 8.2e-18 64.5 0.1 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001082570.2_39729001_2 - 2.3e-32 110.5 0.1 5.3e-28 96.5 0.3 4.4 5 0 0 5 5 5 2 Cadherin-like Cadherin_tail PF15974.3 001082570.2_39729001_2 - 1.9e-25 89.6 3.3 4.1e-25 88.5 3.3 1.5 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 001082570.2_39729001_2 - 1.3e-18 67.4 0.0 2.8e-18 66.3 0.0 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001082570.2_39729001_2 - 7e-05 22.7 2.3 15 5.5 0.0 5.1 5 1 0 5 5 5 2 Cadherin-like Cadherin PF00028.15 001082557.2_39729001_3 - 2.3e-83 274.6 0.1 8e-16 58.1 0.1 6.2 5 1 1 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001082557.2_39729001_3 - 1.4e-37 127.3 0.1 2.9e-32 110.2 0.0 4.5 5 0 0 5 5 5 2 Cadherin-like Cadherin_tail PF15974.3 001082557.2_39729001_3 - 2e-25 89.5 3.3 4e-25 88.6 3.3 1.5 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 001082557.2_39729001_3 - 2.4e-23 82.6 0.3 5.7e-23 81.4 0.3 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001082557.2_39729001_3 - 0.00042 20.2 0.5 4.7 7.1 0.0 4.8 5 0 0 5 5 5 1 Cadherin-like Cadherin PF00028.15 001082586.2_39729001_3 - 2.5e-77 255.3 0.0 3.9e-19 68.8 0.0 6.4 6 0 0 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 001082586.2_39729001_3 - 2.1e-63 212.4 4.7 3.6e-63 211.7 4.7 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 001082586.2_39729001_3 - 3.7e-31 106.6 0.3 3.2e-28 97.2 0.1 3.8 4 0 0 4 4 4 1 Cadherin-like Cadherin_C_2 PF16492.3 001082586.2_39729001_3 - 8.5e-06 26.3 0.1 2.9e-05 24.6 0.1 2.0 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal RhoGAP PF00620.25 146894.1_26229120_2 - 7.9e-40 136.0 0.0 1.2e-39 135.4 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.27 146894.1_26229120_2 - 1.4e-13 51.1 3.7 6.9e-09 36.0 1.6 2.5 2 0 0 2 2 2 2 PH domain RA PF00788.21 146894.1_26229120_2 - 5.2e-05 23.7 0.0 0.00013 22.4 0.0 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain DNA_pol_phi PF04931.11 146894.1_26229120_2 - 0.0015 16.6 0.4 0.0022 16.1 0.4 1.1 1 0 0 1 1 1 1 DNA polymerase phi ArfGap PF01412.16 146894.1_26229120_3 - 8.9e-34 115.9 2.0 1.3e-33 115.3 1.1 1.8 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf PH PF00169.27 146894.1_26229120_3 - 4.1e-31 107.5 5.1 1.4e-11 44.7 0.4 3.7 3 0 0 3 3 3 3 PH domain SAM_1 PF00536.28 146894.1_26229120_3 - 3.7e-10 40.0 0.1 1e-09 38.5 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 146894.1_26229120_3 - 1.6e-09 37.6 0.1 3.5e-09 36.5 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_6 PF15406.4 146894.1_26229120_3 - 2.4e-09 37.3 0.1 6e-05 23.2 0.0 3.5 3 0 0 3 3 3 2 Pleckstrin homology domain PH_3 PF14593.4 146894.1_26229120_3 - 4.5e-08 33.0 2.3 0.0031 17.5 0.1 3.6 3 0 0 3 3 3 2 PH domain PH_11 PF15413.4 146894.1_26229120_3 - 6.3e-07 29.6 7.2 0.12 12.7 1.3 4.9 4 1 0 4 4 4 2 Pleckstrin homology domain PH_8 PF15409.4 146894.1_26229120_3 - 0.00028 21.0 2.2 0.65 10.2 0.1 3.9 3 1 0 3 3 3 1 Pleckstrin homology domain PH_2 PF08458.8 146894.1_26229120_3 - 0.018 15.3 0.6 3.5 7.9 0.1 3.0 3 0 0 3 3 3 0 Plant pleckstrin homology-like region PH_9 PF15410.4 146894.1_26229120_3 - 0.058 13.6 1.0 34 4.7 0.0 3.7 3 0 0 3 3 3 0 Pleckstrin homology domain PARP PF00644.18 136606.1_26226120_2 - 0.00035 20.1 0.0 0.00063 19.3 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP PF00644.18 136594.1_26226120_2 - 0.00042 19.9 0.0 0.00065 19.3 0.0 1.1 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Rdx PF10262.7 001166396.1_45723001_2 - 2.6e-08 33.8 0.0 5.1e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Rdx family DUF963 PF06131.9 001166396.1_45723001_2 - 0.0016 17.7 7.4 0.0016 17.7 7.4 3.4 3 0 0 3 3 3 1 Schizosaccharomyces pombe repeat of unknown function (DUF963) DsbC_N PF10411.7 001166396.1_45723001_2 - 0.012 14.9 0.0 0.026 13.8 0.0 1.6 1 0 0 1 1 1 0 Disulfide bond isomerase protein N-terminus Rdx PF10262.7 146923.1_45723120_1 - 3e-08 33.6 0.0 4.4e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Rdx family DsbC_N PF10411.7 146923.1_45723120_1 - 0.014 14.7 0.0 0.023 14.0 0.0 1.3 1 0 0 1 1 1 0 Disulfide bond isomerase protein N-terminus DUF963 PF06131.9 146923.1_45723120_2 - 0.0014 17.9 7.4 0.0014 17.9 7.4 3.4 3 0 0 3 3 3 2 Schizosaccharomyces pombe repeat of unknown function (DUF963) DUF963 PF06131.9 146924.1_45723120_2 - 0.0019 17.4 8.0 0.0019 17.4 8.0 3.5 3 0 0 3 3 3 2 Schizosaccharomyces pombe repeat of unknown function (DUF963) p450 PF00067.20 134127.1_32925001_2 - 2.4e-131 438.6 0.0 2.9e-131 438.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Arfaptin PF06456.11 146928.1_26226120_1 - 2.7e-91 305.1 10.3 3.7e-91 304.6 10.3 1.2 1 0 0 1 1 1 1 Arfaptin-like domain ICA69 PF04629.12 146928.1_26226120_1 - 1.3e-62 212.3 12.3 3.7e-62 210.8 12.3 1.8 1 1 0 1 1 1 1 Islet cell autoantigen ICA69, C-terminal domain BRF1 PF07741.11 001109578.1_45722001_1 - 2.4 8.4 10.4 3.9 7.7 10.4 1.3 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Collagen PF01391.16 001109578.1_45722001_3 - 0.004 16.8 37.7 0.004 16.8 37.7 1.8 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) IncA PF04156.12 001109578.1_45722001_3 - 0.11 12.1 1.9 0.14 11.8 1.9 1.2 1 0 0 1 1 1 0 IncA protein Pro-rich PF15240.4 001109578.1_45722001_3 - 0.27 11.4 31.9 0.74 10.0 31.9 1.6 1 1 0 1 1 1 0 Proline-rich SBDS_C PF09377.8 001244393.1_49824001_1 - 5e-39 132.8 1.5 9.4e-39 131.9 1.5 1.4 1 0 0 1 1 1 1 SBDS protein C-terminal domain SBDS PF01172.16 001244393.1_49824001_1 - 2.1e-32 110.9 0.7 3.6e-32 110.1 0.7 1.4 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Dehydratase_SU PF02287.13 001244393.1_49824001_1 - 0.14 12.1 1.0 0.24 11.3 1.0 1.3 1 0 0 1 1 1 0 Dehydratase small subunit Actin PF00022.17 146950.1_26225120_1 - 2.3e-29 102.1 0.0 3.4e-29 101.6 0.0 1.1 1 0 0 1 1 1 1 Actin Actin PF00022.17 146950.1_26225120_3 - 5e-44 150.4 0.0 2.3e-35 121.9 0.0 3.1 2 1 0 2 2 2 2 Actin DUF4097 PF13349.4 026879.1_26225120_1 - 2.7e-09 36.6 15.6 2.5e-07 30.2 8.8 2.2 1 1 1 2 2 2 2 Putative adhesin TMEM71 PF15121.4 026879.1_26225120_1 - 0.0052 16.3 0.0 0.0086 15.6 0.0 1.3 1 0 0 1 1 1 1 TMEM71 protein family Myosin_N PF02736.17 026879.1_26225120_1 - 0.015 15.0 7.0 4.2 7.1 0.2 3.8 2 1 1 3 3 3 0 Myosin N-terminal SH3-like domain DUF2807 PF10988.6 026879.1_26225120_1 - 0.15 11.7 7.8 0.037 13.7 2.0 2.2 1 1 0 2 2 2 0 Putative auto-transporter adhesin, head GIN domain DUF2642 PF10842.6 026879.1_26225120_1 - 0.22 11.3 1.6 1.9 8.3 0.3 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2642) LRR_4 PF12799.5 177449.3_32924001_2 - 4.8e-15 55.2 20.2 0.0061 16.8 0.0 9.0 6 3 2 10 10 10 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 177449.3_32924001_2 - 2.6e-13 48.7 20.3 0.51 10.4 0.1 11.9 12 1 1 13 13 13 4 Leucine Rich repeat LRR_1 PF00560.31 177449.3_32924001_2 - 3.9e-07 29.5 25.9 8.3 7.2 0.1 11.8 11 2 1 12 12 12 3 Leucine Rich Repeat LRR_8 PF13855.4 177449.3_32924001_2 - 0.051 13.2 22.5 2.1 8.1 0.3 7.5 6 4 1 7 7 7 0 Leucine rich repeat Ste50p-SAM PF09235.8 177449.3_32924001_2 - 0.1 12.7 3.2 26 5.0 0.1 4.3 4 1 1 5 5 5 0 Ste50p, sterile alpha motif F-box-like PF12937.5 177449.3_32924001_3 - 1.1e-07 31.5 0.1 3.8e-07 29.8 0.1 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 177449.3_32924001_3 - 3.2e-05 23.5 0.0 3.2e-05 23.5 0.0 2.2 3 0 0 3 3 3 1 F-box domain EF-hand_5 PF13202.4 003713.1_26226120_2 - 0.0004 19.6 0.0 0.00068 18.9 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.30 003713.1_26226120_2 - 0.00059 19.1 0.0 0.00098 18.4 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.4 003713.1_26226120_2 - 0.00091 18.9 0.0 0.0019 17.8 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain V-set PF07686.15 001163251.1_37923001_1 - 3.4e-23 81.7 0.7 1.2e-19 70.3 0.0 3.1 2 1 1 3 3 3 2 Immunoglobulin V-set domain Ig_3 PF13927.4 001163251.1_37923001_1 - 2.5e-13 50.3 0.2 2.2e-06 28.0 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001163251.1_37923001_1 - 2.9e-13 49.6 0.0 4.6e-06 26.5 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 001163251.1_37923001_1 - 4.4e-13 49.1 0.1 4.1e-05 23.5 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001163251.1_37923001_1 - 1.2e-09 38.3 0.5 6.9e-05 23.0 0.1 2.9 2 1 0 2 2 2 2 Immunoglobulin domain Herpes_gE PF02480.14 001163251.1_37923001_1 - 0.0045 15.7 0.1 0.29 9.7 0.0 2.7 1 1 2 3 3 3 1 Alphaherpesvirus glycoprotein E EphA2_TM PF14575.4 001163251.1_37923001_1 - 0.0074 16.9 0.1 0.027 15.1 0.0 1.9 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain TMEM52 PF14979.4 001163251.1_37923001_1 - 0.012 15.4 0.0 0.12 12.2 0.0 2.1 2 0 0 2 2 2 0 Transmembrane 52 C2-set PF05790.13 001163251.1_37923001_1 - 0.015 15.3 0.2 2.8 8.1 0.0 2.5 2 0 0 2 2 2 0 Immunoglobulin C2-set domain Shisa PF13908.4 001163251.1_37923001_1 - 0.027 14.6 0.1 0.044 13.9 0.1 1.4 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator Syndecan PF01034.18 001163251.1_37923001_1 - 0.036 13.9 0.0 0.075 12.8 0.0 1.5 1 0 0 1 1 1 0 Syndecan domain DUF1191 PF06697.10 001163251.1_37923001_1 - 0.081 12.0 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) PDGLE PF13190.4 001163251.1_37923001_1 - 0.13 12.0 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 PDGLE domain Izumo-Ig PF16706.3 001163251.1_37923001_1 - 0.14 12.1 0.0 3.5 7.6 0.0 2.4 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain UPF0552 PF10574.7 001242426.1_39726001_3 - 1.4e-105 351.4 0.0 1.8e-105 351.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0552 UPF0058 PF01893.14 001242426.1_39726001_3 - 0.076 13.2 0.1 0.14 12.3 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0058 Actin PF00022.17 001257417.1_29625001_1 - 3.4e-133 444.1 0.0 1.4e-132 442.1 0.0 1.7 1 1 0 1 1 1 1 Actin Yae1_N PF09811.7 001110555.1_32925001_1 - 1.9 8.1 4.1 3.1 7.4 4.1 1.3 1 0 0 1 1 1 0 Essential protein Yae1, N terminal Histone PF00125.22 001110555.1_32925001_2 - 1.2e-24 87.1 0.5 1.7e-24 86.6 0.5 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 001110555.1_32925001_2 - 8.6e-06 25.8 0.0 1.6e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.11 001110555.1_32925001_2 - 0.02 15.2 0.0 0.035 14.5 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A YscO-like PF16789.3 001110555.1_32925001_2 - 0.055 13.4 0.2 0.081 12.8 0.2 1.1 1 0 0 1 1 1 0 YscO-like protein Actin PF00022.17 001280133.1_39724001_3 - 1.3e-84 284.0 0.0 1.4e-83 280.7 0.0 1.9 1 1 0 1 1 1 1 Actin TPK_B1_binding PF04265.12 146935.1_26225120_1 - 6.1e-24 83.4 0.1 9.6e-24 82.8 0.1 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain TPK_catalytic PF04263.14 146935.1_26225120_1 - 8.2e-18 64.5 0.0 1.4e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain SDA1 PF05285.10 015605.1_32926120_1 - 5.6e-05 22.6 10.3 0.00011 21.7 10.3 1.4 1 0 0 1 1 1 1 SDA1 Mpp10 PF04006.10 015605.1_32926120_1 - 9e-05 21.0 10.0 0.00013 20.4 10.0 1.2 1 0 0 1 1 1 1 Mpp10 protein RNA_pol_Rpc4 PF05132.12 015605.1_32926120_1 - 0.0002 21.7 0.5 0.00046 20.5 0.5 1.5 1 0 0 1 1 1 1 RNA polymerase III RPC4 SpoIIP PF07454.9 015605.1_32926120_1 - 0.0012 18.2 3.3 0.002 17.5 3.3 1.3 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) DUF1777 PF08648.10 015605.1_32926120_1 - 0.0016 18.6 2.7 0.0031 17.7 2.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) DUF2052 PF09747.7 015605.1_32926120_1 - 0.0016 18.5 10.2 0.0016 18.5 10.2 1.6 2 0 0 2 2 1 1 Coiled-coil domain containing protein (DUF2052) BUD22 PF09073.8 015605.1_32926120_1 - 0.0037 16.5 11.4 0.0064 15.8 11.4 1.2 1 0 0 1 1 1 1 BUD22 Tim54 PF11711.6 015605.1_32926120_1 - 0.0056 15.4 6.8 0.0086 14.8 6.8 1.2 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Nop14 PF04147.10 015605.1_32926120_1 - 0.0087 14.2 16.8 0.013 13.6 16.8 1.1 1 0 0 1 1 1 1 Nop14-like family Eapp_C PF10238.7 015605.1_32926120_1 - 0.011 15.8 1.5 0.011 15.8 1.5 1.8 2 0 0 2 2 2 0 E2F-associated phosphoprotein TRAP_alpha PF03896.14 015605.1_32926120_1 - 0.013 14.6 8.2 0.02 14.0 8.2 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Presenilin PF01080.15 015605.1_32926120_1 - 0.022 13.4 2.1 0.03 12.9 2.1 1.1 1 0 0 1 1 1 0 Presenilin Connexin PF00029.17 015605.1_32926120_1 - 0.038 13.6 3.3 0.07 12.8 3.3 1.3 1 0 0 1 1 1 0 Connexin FAM176 PF14851.4 015605.1_32926120_1 - 0.042 13.4 10.1 0.091 12.3 10.1 1.5 1 0 0 1 1 1 0 FAM176 family Zip PF02535.20 015605.1_32926120_1 - 0.053 12.6 1.3 0.089 11.9 1.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CPSF100_C PF13299.4 015605.1_32926120_1 - 0.056 13.5 7.9 0.12 12.4 7.9 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF1510 PF07423.9 015605.1_32926120_1 - 0.063 12.6 21.9 0.12 11.6 21.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CobT PF06213.10 015605.1_32926120_1 - 0.42 9.8 21.6 0.87 8.8 21.6 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF913 PF06025.10 015605.1_32926120_1 - 0.85 8.4 5.3 1.3 7.8 5.3 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CDC27 PF09507.8 015605.1_32926120_1 - 1.1 8.4 17.3 1.8 7.7 17.3 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF3306 PF11748.6 015605.1_32926120_1 - 2.1 9.1 11.0 4.7 8.0 11.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) AIM3 PF17096.3 015605.1_32926120_1 - 3.7 8.4 5.8 11 6.9 5.8 1.7 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 3 Sigma70_ner PF04546.11 015605.1_32926120_1 - 5.7 6.6 21.5 9.3 5.9 21.5 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region Afi1 PF07792.10 015605.1_32926120_1 - 6 7.2 11.0 18 5.7 11.0 1.8 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Conotoxin PF02950.15 015605.1_32926120_1 - 6.5 7.7 8.0 0.89 10.5 2.8 2.3 2 0 0 2 2 1 0 Conotoxin OAD_gamma PF04277.11 015605.1_32926120_1 - 8.8 6.9 6.5 30 5.2 6.5 1.9 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Paralemmin PF03285.13 147150.2_26229001_1 - 3.9e-19 69.3 3.5 3.9e-19 69.3 3.5 3.3 3 1 1 4 4 4 1 Paralemmin AKAP2_C PF15304.4 147150.2_26229001_1 - 6.8e-14 51.8 5.4 6.8e-14 51.8 5.4 3.3 3 1 0 3 3 3 1 A-kinase anchor protein 2 C-terminus Eapp_C PF10238.7 001136235.1_32925001_1 - 2.3 8.2 4.7 3.6 7.5 4.7 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein AP3D1 PF06375.9 001136235.1_32925001_1 - 4.6 7.4 12.0 7 6.8 12.0 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 BTB_2 PF02214.20 001136235.1_32925001_2 - 6.8e-15 55.1 0.0 1.3e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 001142943.1_32927001_1 - 2.6e-73 239.3 95.4 4.4e-08 33.1 1.6 13.3 12 1 0 12 12 12 11 Zinc-finger double domain zf-C2H2 PF00096.24 001142943.1_32927001_1 - 1.6e-44 147.8 99.0 4.6e-06 26.7 2.9 13.7 13 0 0 13 13 13 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001142943.1_32927001_1 - 6.6e-25 85.5 100.4 0.0011 19.5 2.2 13.9 14 0 0 14 14 13 11 C2H2-type zinc finger KRAB PF01352.25 001142943.1_32927001_1 - 6.8e-20 70.3 1.5 1.2e-19 69.6 1.5 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 001142943.1_32927001_1 - 4.9e-06 26.2 81.7 0.032 14.1 0.2 13.8 15 0 0 15 15 15 7 C2H2-type zinc finger XPA_N PF01286.16 001142943.1_32927001_1 - 8.7e-06 25.5 51.3 1.3 9.0 0.2 11.7 12 0 0 12 12 12 5 XPA protein N-terminal Zn-ribbon_8 PF09723.8 001142943.1_32927001_1 - 6.2e-05 22.9 54.5 0.084 12.9 3.4 7.7 3 1 6 9 9 9 6 Zinc ribbon domain zf-LYAR PF08790.9 001142943.1_32927001_1 - 0.0052 16.5 46.5 3.9 7.3 0.1 11.4 11 0 0 11 11 11 2 LYAR-type C2HC zinc finger zf-C2H2_jaz PF12171.6 001142943.1_32927001_1 - 0.02 15.1 81.2 0.11 12.7 2.2 11.9 13 0 0 13 13 13 0 Zinc-finger double-stranded RNA-binding DUF3936 PF13072.4 001142943.1_32927001_1 - 0.03 14.0 0.9 12 5.6 0.2 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3936) BolA PF01722.16 001142943.1_32927001_1 - 0.29 11.3 21.5 2.1 8.6 0.1 5.3 6 0 0 6 6 6 0 BolA-like protein MHC_II_beta PF00969.17 001314217.1_09022001_1 - 3.3e-34 116.7 0.1 5.1e-34 116.1 0.1 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001314217.1_09022001_1 - 8.2e-25 87.0 0.5 2e-24 85.7 0.2 1.8 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_2 PF13895.4 001314217.1_09022001_1 - 0.0074 16.5 0.1 0.013 15.6 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain DUF202 PF02656.13 001314217.1_09022001_1 - 0.037 14.3 0.0 0.07 13.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) ig PF00047.23 001314217.1_09022001_1 - 0.13 12.3 0.2 0.3 11.2 0.2 1.7 1 1 0 1 1 1 0 Immunoglobulin domain Glycos_transf_2 PF00535.24 001265889.1_29627001_1 - 1.4e-27 96.4 0.0 2.2e-27 95.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.20 001265889.1_29627001_1 - 1.9e-17 63.5 0.0 3.4e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.4 001265889.1_29627001_1 - 0.07 13.8 0.1 0.2 12.3 0.1 1.7 1 0 0 1 1 1 0 Ricin-type beta-trefoil lectin domain-like HALZ PF02183.16 028397.1_26227120_2 - 0.079 13.0 0.2 0.079 13.0 0.2 3.8 4 0 0 4 4 4 0 Homeobox associated leucine zipper UVR PF02151.17 028397.1_26227120_2 - 0.16 11.6 4.9 0.58 9.8 4.9 2.0 1 0 0 1 1 1 0 UvrB/uvrC motif Reo_sigmaC PF04582.10 028397.1_26227120_2 - 0.38 10.0 1.0 0.52 9.5 0.2 1.7 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Mnd1 PF03962.13 028397.1_26227120_2 - 0.91 9.2 14.3 0.04 13.7 3.9 2.7 2 1 1 3 3 3 0 Mnd1 family ADIP PF11559.6 028397.1_26227120_2 - 1.4 8.8 23.5 0.49 10.3 3.1 4.2 4 0 0 4 4 4 0 Afadin- and alpha -actinin-Binding Macoilin PF09726.7 028397.1_26227120_2 - 2.5 6.4 11.3 0.088 11.2 5.3 1.5 2 0 0 2 2 2 0 Transmembrane protein Lebercilin PF15619.4 028397.1_26227120_2 - 5.4 6.5 20.9 0.67 9.4 3.3 3.4 3 1 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease TPR_MLP1_2 PF07926.10 028397.1_26227120_2 - 9.8 6.1 19.4 2.2 8.2 3.2 4.0 3 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein Translin PF01997.14 028397.1_26227120_3 - 8.4e-27 94.4 1.2 1.2e-26 93.9 1.2 1.1 1 0 0 1 1 1 1 Translin family zf-H2C2_2 PF13465.4 001285760.1_09025001_3 - 1.1e-12 47.6 29.1 1.3e-07 31.6 3.1 4.3 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.24 001285760.1_09025001_3 - 6.4e-10 38.8 33.8 0.00011 22.4 1.8 4.2 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001285760.1_09025001_3 - 6e-06 26.5 29.9 0.00062 20.3 1.5 4.3 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_8 PF15909.3 001285760.1_09025001_3 - 0.019 15.1 3.3 0.051 13.7 3.3 1.7 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.6 001285760.1_09025001_3 - 0.23 11.7 4.4 6.8 7.0 0.4 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 001285760.1_09025001_3 - 0.33 11.1 9.3 1.1 9.5 2.1 2.9 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding WD40 PF00400.30 028220.3_32929001_3 - 8.3e-30 102.3 35.0 9e-07 29.4 0.2 10.0 10 0 0 10 10 10 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 028220.3_32929001_3 - 1.7e-19 69.8 0.7 0.0002 21.4 0.0 5.8 3 2 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 028220.3_32929001_3 - 0.00034 19.2 2.5 0.19 10.1 0.0 4.2 5 0 0 5 5 5 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.3 028220.3_32929001_3 - 0.005 15.7 1.4 1.2 7.9 0.0 3.4 4 0 0 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Coatomer_WDAD PF04053.12 028220.3_32929001_3 - 0.039 12.9 0.6 12 4.7 0.0 3.2 4 1 1 5 5 5 0 Coatomer WD associated region DUF3915 PF13054.4 033536.1_32926120_3 - 1.9 8.3 5.4 3.4 7.5 5.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Tektin PF03148.12 037872.1_26224120_3 - 8.6e-52 176.0 7.4 8.2e-39 133.3 2.7 2.0 2 0 0 2 2 2 2 Tektin family Fib_alpha PF08702.8 037872.1_26224120_3 - 0.088 12.9 0.8 11 6.0 0.0 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family ATG16 PF08614.9 037872.1_26224120_3 - 1.2 9.1 4.4 0.71 9.9 1.7 1.8 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) TMF_DNA_bd PF12329.6 037872.1_26224120_3 - 1.3 9.0 3.9 18 5.3 0.4 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Cauli_VI PF01693.14 037972.1_32924120_3 - 8.6e-11 41.8 15.4 30 4.9 0.0 10.4 10 1 0 10 10 10 3 Caulimovirus viroplasmin Toxin_37 PF11415.6 037972.1_32924120_3 - 2.4e-07 30.3 7.5 29 4.5 0.0 9.6 1 1 9 11 11 11 2 Antifungal peptide termicin DUF3970 PF13113.4 037972.1_32924120_3 - 0.41 10.8 6.7 3.2e+02 1.5 0.0 5.5 4 3 4 8 8 8 0 Protein of unknown function (DUF3970) F-box-like PF12937.5 045922.1_32923120_2 - 4.9 7.0 10.1 3.6 7.4 1.4 2.9 2 0 0 2 2 2 0 F-box-like zf-H2C2_2 PF13465.4 040355.1_32929120_1 - 1.9e-91 296.6 117.0 1.5e-08 34.5 0.5 15.5 15 0 0 15 15 15 12 Zinc-finger double domain zf-C2H2 PF00096.24 040355.1_32929120_1 - 3.6e-51 168.7 141.2 3.3e-05 24.0 5.6 15.2 15 0 0 15 15 15 12 Zinc finger, C2H2 type KRAB PF01352.25 040355.1_32929120_1 - 1.2e-18 66.4 2.4 2.2e-18 65.5 2.4 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 040355.1_32929120_1 - 1.2e-18 66.0 125.3 0.012 16.2 1.7 14.1 14 0 0 14 14 14 10 C2H2-type zinc finger zf-C2H2_11 PF16622.3 040355.1_32929120_1 - 4.6e-11 42.1 82.3 0.0034 17.0 0.6 13.8 14 0 0 14 14 14 9 zinc-finger C2H2-type UXS1_N PF11803.6 040355.1_32929120_1 - 0.0005 20.3 0.2 3.9 7.8 0.0 4.9 4 2 1 5 5 5 1 UDP-glucuronate decarboxylase N-terminal ESP PF16590.3 001256051.1_32921001_3 - 4.4e-23 81.2 0.0 7.3e-23 80.5 0.0 1.3 1 0 0 1 1 1 1 Exocrine gland-secreting peptide SSXT PF05030.10 001244804.2_49829001_3 - 3.1e-30 103.5 4.2 5.2e-30 102.8 4.2 1.4 1 0 0 1 1 1 1 SSXT protein (N-terminal region) ubiquitin PF00240.21 033523.1_32922120_1 - 4.4e-33 112.7 0.3 6.4e-33 112.2 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.15 033523.1_32922120_1 - 3.2e-32 110.0 11.2 7.9e-32 108.7 11.2 1.7 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.6 033523.1_32922120_1 - 9.5e-16 57.3 0.3 1.6e-15 56.5 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 033523.1_32922120_1 - 0.00021 21.5 0.1 0.00069 19.9 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 033523.1_32922120_1 - 0.022 14.8 0.0 0.044 13.7 0.0 1.6 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 033523.1_32922120_1 - 0.084 13.3 0.1 0.12 12.8 0.1 1.4 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain KRAB PF01352.25 027963.1_32929120_1 - 0.025 14.1 0.2 0.048 13.2 0.2 1.4 1 0 0 1 1 1 0 KRAB box zf-H2C2_2 PF13465.4 027963.1_32929120_2 - 0.017 15.4 23.7 0.048 14.0 2.8 5.2 5 0 0 5 5 5 0 Zinc-finger double domain HypA PF01155.17 027963.1_32929120_2 - 8.7 6.3 14.8 4.2 7.3 2.9 3.1 2 1 1 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Serpin PF00079.18 033450.1_32925120_2 - 8.9e-92 308.1 0.4 1.1e-91 307.8 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.18 033450.1_32925120_3 - 3.3e-18 66.0 0.0 4.3e-18 65.6 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Copper-fist PF00649.16 015498.2_32928120_1 - 0.018 14.4 1.7 0.053 12.9 1.7 1.8 1 0 0 1 1 1 0 Copper fist DNA binding domain RRM_1 PF00076.20 038081.2_32926120_2 - 3.4e-28 97.1 0.0 1.3e-13 50.4 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Smg4_UPF3 PF03467.13 038081.2_32926120_2 - 0.042 13.8 0.0 11 5.9 0.0 2.3 2 0 0 2 2 2 0 Smg-4/UPF3 family Fer2 PF00111.25 038081.2_32926120_3 - 2.8e-09 36.6 0.1 5.5e-09 35.7 0.1 1.5 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Hormone_3 PF00159.16 001009452.1_39521001_2 - 2.8e-19 68.8 1.4 6.1e-19 67.7 1.4 1.6 1 0 0 1 1 1 1 Pancreatic hormone peptide Osteopontin PF00865.16 001009224.1_39525001_2 - 1.1e-92 310.5 54.1 2.2e-76 257.0 31.8 2.2 1 1 1 2 2 2 2 Osteopontin DUF1510 PF07423.9 001009224.1_39525001_2 - 0.0045 16.3 6.2 0.0045 16.3 6.2 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1510) 7tm_1 PF00001.19 001009126.1_39723001_1 - 5e-51 173.4 15.3 7.8e-51 172.7 15.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001009126.1_39723001_1 - 3.4e-06 26.9 10.5 3.6e-05 23.5 10.5 2.0 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001009126.1_39723001_1 - 8.9e-06 25.1 12.5 1.6e-05 24.3 12.5 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF1385 PF07136.9 001009126.1_39723001_1 - 0.52 9.4 5.7 0.56 9.3 1.2 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1385) Cys_knot PF00007.20 001009380.1_39522001_2 - 9.2e-32 109.3 4.7 1.2e-31 109.0 4.7 1.1 1 0 0 1 1 1 1 Cystine-knot domain Connexin PF00029.17 019308.1_45722001_1 - 1.2e-89 299.9 5.4 1.5e-89 299.5 5.4 1.1 1 0 0 1 1 1 1 Connexin Ninjurin PF04923.10 019308.1_45722001_1 - 0.067 13.0 2.0 1.6 8.6 0.1 2.5 2 1 0 2 2 2 0 Ninjurin DUF1218 PF06749.10 019308.1_45722001_1 - 0.17 12.3 3.6 2.4 8.6 0.8 3.2 2 2 1 3 3 3 0 Protein of unknown function (DUF1218) Popeye PF04831.11 019308.1_45722001_1 - 0.23 11.5 7.0 3 7.9 0.2 3.8 4 0 0 4 4 4 0 Popeye protein conserved region zf-DHHC PF01529.18 019308.1_45722001_1 - 0.67 9.9 9.6 4.5 7.2 0.0 2.5 2 1 0 2 2 2 0 DHHC palmitoyltransferase DUF3139 PF11337.6 019308.1_45722001_1 - 0.9 10.0 3.4 0.39 11.2 0.2 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3139) TBD PF12845.5 172021.2_45727001_2 - 1.7e-17 62.9 0.1 7e-17 60.9 0.1 2.1 1 0 0 1 1 1 1 TBD domain IncA PF04156.12 172021.2_45727001_2 - 0.0056 16.4 3.1 0.0056 16.4 3.1 2.6 2 1 0 2 2 2 1 IncA protein CT_C_D PF02682.14 172021.2_45727001_2 - 0.34 10.5 2.1 0.71 9.4 0.3 2.0 2 0 0 2 2 2 0 Carboxyltransferase domain, subdomain C and D Seryl_tRNA_N PF02403.20 172021.2_45727001_2 - 0.45 10.6 10.4 0.14 12.3 1.5 2.3 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain APG6 PF04111.10 172021.2_45727001_2 - 1.9 7.6 14.7 2.8 7.1 3.1 2.1 2 0 0 2 2 2 0 Autophagy protein Apg6 Mod_r PF07200.11 172021.2_45727001_2 - 2.8 7.9 15.1 0.064 13.2 4.8 2.3 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Cor1 PF04803.10 172021.2_45727001_2 - 7.6 6.6 13.9 0.48 10.5 8.2 1.8 2 0 0 2 2 2 0 Cor1/Xlr/Xmr conserved region FTA4 PF13093.4 172021.2_45727001_2 - 7.9 6.2 11.7 1.7 8.4 2.7 2.7 2 1 0 2 2 2 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 eIF-1a PF01176.17 001008305.1_45726001_1 - 2.9e-18 65.3 0.2 1.3e-17 63.3 0.1 2.0 2 0 0 2 2 2 1 Translation initiation factor 1A / IF-1 Cystatin PF00031.19 001009098.1_39723001_1 - 1.4e-24 86.0 0.0 4e-19 68.5 0.0 2.3 2 0 0 2 2 2 2 Cystatin domain Cathelicidins PF00666.15 001009098.1_39723001_1 - 0.025 14.7 1.1 0.17 12.1 0.2 2.3 2 1 0 2 2 2 0 Cathelicidin Interferon PF00143.17 001101735.1_39522001_3 - 1e-63 214.2 0.5 1.2e-63 213.9 0.5 1.1 1 0 0 1 1 1 1 Interferon alpha/beta domain LisH PF08513.9 001101735.1_39522001_3 - 0.047 13.6 0.0 0.097 12.6 0.0 1.5 1 0 0 1 1 1 0 LisH Trypsin PF00089.24 001009389.2_22422001_2 - 6.9e-68 228.6 5.9 7.9e-68 228.4 5.9 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001009389.2_22422001_2 - 6.4e-09 36.7 0.2 1.1e-08 36.0 0.2 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001009389.2_22422001_2 - 0.0099 16.1 0.2 0.022 15.0 0.2 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) TPMT PF05724.9 001009836.1_22422001_3 - 3.1e-78 262.3 0.0 3.7e-78 262.0 0.0 1.1 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_25 PF13649.4 001009836.1_22422001_3 - 0.059 14.0 0.0 0.63 10.7 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain Glyco_hydro_56 PF01630.16 214441.1_49825001_2 - 3.9e-132 440.2 0.1 4.6e-132 439.9 0.1 1.1 1 0 0 1 1 1 1 Hyaluronidase EGF PF00008.25 214441.1_49825001_2 - 0.048 13.8 8.4 1.4 9.1 1.0 2.8 3 0 0 3 3 3 0 EGF-like domain EGF_2 PF07974.11 214441.1_49825001_2 - 0.1 12.8 7.5 2.8 8.3 1.5 2.7 2 0 0 2 2 2 0 EGF-like domain Acetyltransf_1 PF00583.23 001009461.1_39522001_3 - 9.9e-13 48.2 0.0 1.3e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.5 001009461.1_39522001_3 - 3.4e-08 33.3 0.0 4.8e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.5 001009461.1_39522001_3 - 7.3e-06 26.2 0.0 1.1e-05 25.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GM_CSF PF01109.15 001009846.1_22421001_1 - 1.3e-63 212.5 0.4 1.4e-63 212.3 0.4 1.0 1 0 0 1 1 1 1 Granulocyte-macrophage colony-stimulating factor DUF1722 PF08349.9 001009846.1_22421001_1 - 0.0049 17.0 0.0 0.0078 16.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1722) UbiA PF01040.16 027873.2_32926001_2 - 2.7e-40 138.1 10.5 4.1e-40 137.6 10.5 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family 7tm_4 PF13853.4 001000876.1_45722001_1 - 3.5e-55 187.6 25.8 4.2e-55 187.3 25.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001000876.1_45722001_1 - 8.9e-23 80.7 22.4 1.6e-22 79.9 22.4 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001000876.1_45722001_1 - 1.2e-05 24.7 25.8 2e-05 24.0 25.8 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TAS2R PF05296.11 001009105.1_39722001_1 - 3.6e-113 377.5 23.1 4e-113 377.4 23.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Lig_chan PF00060.24 001009105.1_39722001_1 - 0.18 11.5 1.6 1.3 8.7 1.6 2.4 1 1 0 1 1 1 0 Ligand-gated ion channel COX7a PF02238.13 001009105.1_39722001_1 - 2.2 8.6 4.9 3.9 7.8 0.3 3.1 3 0 0 3 3 3 0 Cytochrome c oxidase subunit VII TAS2R PF05296.11 001009141.1_39722001_1 - 4.4e-109 364.1 39.6 4.9e-109 364.0 39.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF1280 PF06918.12 001009141.1_39722001_1 - 0.072 12.5 1.0 0.11 11.9 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1280) OSTbeta PF15048.4 001009141.1_39722001_1 - 0.13 12.3 3.5 4.3 7.3 2.5 2.7 1 1 1 2 2 2 0 Organic solute transporter subunit beta protein Cytochrom_B561 PF03188.14 001007753.1_45723001_2 - 2.6e-34 118.1 6.5 2.6e-34 118.1 6.5 1.5 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 DUF3021 PF11457.6 001007753.1_45723001_2 - 1.5 9.1 5.5 3.3 7.9 1.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3021) MIP PF00230.18 001009194.1_39522001_2 - 3.6e-83 278.6 7.1 4.2e-83 278.4 7.1 1.0 1 0 0 1 1 1 1 Major intrinsic protein DUF389 PF04087.12 001009194.1_39522001_2 - 0.018 14.9 13.4 0.069 13.1 1.2 3.0 1 1 1 3 3 3 0 Domain of unknown function (DUF389) DUF4672 PF15716.3 001009194.1_39522001_3 - 0.49 9.9 2.9 0.81 9.2 2.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4672) DNase_II PF03265.13 214196.1_49823001_1 - 5.8e-118 393.7 0.0 6.8e-118 393.5 0.0 1.0 1 0 0 1 1 1 1 Deoxyribonuclease II Glyco_hydro_56 PF01630.16 001009754.1_39524001_3 - 4.7e-136 453.1 0.0 5.7e-136 452.8 0.0 1.1 1 0 0 1 1 1 1 Hyaluronidase EGF PF00008.25 001009754.1_39524001_3 - 0.1 12.8 6.2 1.3 9.3 0.4 2.7 2 0 0 2 2 2 0 EGF-like domain IL17 PF06083.9 001005729.1_49823001_3 - 5.1e-27 94.0 1.5 1e-26 93.0 1.5 1.5 1 0 0 1 1 1 1 Interleukin-17 N_NLPC_P60 PF12912.5 001005729.1_49823001_3 - 0.029 14.6 0.0 0.049 13.9 0.0 1.3 1 0 0 1 1 1 0 NLPC_P60 stabilising domain, N term V-ATPase_H_N PF03224.12 214240.1_49824001_1 - 5.9e-102 341.0 11.8 6.2e-102 341.0 9.0 2.0 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.6 214240.1_49824001_1 - 2.7e-46 156.3 0.3 2.7e-46 156.3 0.3 2.2 3 0 0 3 3 3 1 V-ATPase subunit H Arm PF00514.21 214240.1_49824001_1 - 2.4e-06 27.2 0.2 0.028 14.3 0.0 4.9 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat Arm_2 PF04826.11 214240.1_49824001_1 - 0.00081 18.8 0.1 0.0024 17.3 0.0 1.7 2 0 0 2 2 2 1 Armadillo-like HEAT_2 PF13646.4 214240.1_49824001_1 - 0.0022 18.2 0.1 1.5 9.1 0.0 2.8 2 1 0 2 2 2 2 HEAT repeats DUF2326 PF10088.7 214240.1_49824001_1 - 0.03 13.9 0.1 0.073 12.7 0.1 1.6 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2326) HEAT PF02985.20 214240.1_49824001_1 - 0.1 12.8 0.1 1 9.6 0.0 2.8 2 0 0 2 2 2 0 HEAT repeat UCH PF00443.27 214240.1_49824001_1 - 0.26 10.6 1.4 0.45 9.8 1.0 1.6 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Xylo_C PF12529.6 001009086.1_39726001_1 - 5.3e-68 228.1 0.0 8e-68 227.5 0.0 1.3 1 0 0 1 1 1 1 Xylosyltransferase C terminal Branch PF02485.19 001009086.1_39726001_1 - 7.7e-57 192.5 0.4 1e-56 192.0 0.4 1.2 1 0 0 1 1 1 1 Core-2/I-Branching enzyme SCF PF02404.13 001009343.1_22422001_2 - 2.3e-150 499.3 3.5 2.6e-150 499.1 3.5 1.0 1 0 0 1 1 1 1 Stem cell factor DUF4448 PF14610.4 001009343.1_22422001_2 - 0.0026 17.5 0.0 0.0037 16.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Somatostatin PF03002.13 001009196.1_39521001_1 - 3.4e-12 45.9 8.4 5.1e-12 45.4 8.4 1.3 1 0 0 1 1 1 1 Somatostatin/Cortistatin family PRF PF06875.9 001009112.1_39722001_1 - 1.3e-17 63.8 0.0 1.9e-17 63.3 0.0 1.3 1 1 0 1 1 1 1 Plethodontid receptivity factor PRF CNTF PF01110.15 001009112.1_39722001_1 - 3.1e-09 36.3 0.0 4.4e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 Ciliary neurotrophic factor LIF_OSM PF01291.15 001009112.1_39722001_1 - 0.0033 17.5 0.0 0.005 16.9 0.0 1.3 1 0 0 1 1 1 1 LIF / OSM family Glyco_transf_10 PF00852.17 001008978.1_39723001_1 - 2e-66 222.9 5.3 2.9e-66 222.4 5.3 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.3 001008978.1_39723001_1 - 7.1e-42 142.2 5.8 3.7e-41 139.9 0.2 2.8 2 1 1 3 3 3 2 Fucosyltransferase, N-terminal Cys_knot PF00007.20 001009277.1_22421001_1 - 7.8e-33 112.8 2.6 8.9e-33 112.6 2.6 1.0 1 0 0 1 1 1 1 Cystine-knot domain Motilin_ghrelin PF04644.10 001009439.1_39522001_3 - 6.2e-16 57.8 0.6 1.1e-15 57.1 0.6 1.4 1 0 0 1 1 1 1 Motilin/ghrelin Motilin_assoc PF04643.10 001009439.1_39522001_3 - 1.2e-10 41.0 0.1 2.3e-10 40.0 0.0 1.6 2 0 0 2 2 2 1 Motilin/ghrelin-associated peptide GM_CSF PF01109.15 214118.2_49822001_3 - 1.6e-69 231.5 0.5 2.2e-69 231.1 0.5 1.2 1 0 0 1 1 1 1 Granulocyte-macrophage colony-stimulating factor DUF92 PF01940.14 199098.1_45724001_1 - 3.2e-73 245.9 4.7 5.5e-73 245.1 4.7 1.4 1 0 0 1 1 1 1 Integral membrane protein DUF92 Cation_ATPase_C PF00689.19 199098.1_45724001_1 - 0.027 14.0 4.8 0.093 12.3 2.2 2.5 2 0 0 2 2 2 0 Cation transporting ATPase, C-terminus LAGLIDADG_2 PF03161.11 199098.1_45724001_1 - 0.11 12.4 0.1 0.18 11.7 0.1 1.3 1 0 0 1 1 1 0 LAGLIDADG DNA endonuclease family GRIN_C PF15235.4 183183.2_32927001_1 - 3.9e-47 159.7 0.5 1e-46 158.3 0.5 1.7 1 0 0 1 1 1 1 G protein-regulated inducer of neurite outgrowth C-terminus PHO4 PF01384.18 001009839.1_22424001_1 - 6.4e-136 452.7 6.4 8e-136 452.3 6.4 1.1 1 0 0 1 1 1 1 Phosphate transporter family Vpu PF00558.17 001009839.1_22424001_1 - 0.11 12.2 0.2 0.33 10.6 0.2 1.8 1 0 0 1 1 1 0 Vpu protein IL15 PF02372.13 001009207.1_22421001_1 - 4.7e-57 191.6 7.8 4.7e-57 191.6 7.8 1.6 2 0 0 2 2 2 1 Interleukin 15 ApoL PF05461.9 001003403.1_45726001_3 - 1.2e-11 44.4 0.7 1.2e-11 44.4 0.7 1.6 2 0 0 2 2 2 1 Apolipoprotein L TNF PF00229.16 001045510.1_39722001_1 - 6.9e-33 113.2 0.1 8.8e-33 112.8 0.1 1.1 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family Trypsin PF00089.24 001009411.2_39522001_2 - 1.2e-65 221.3 0.0 1.4e-65 221.1 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001009411.2_39522001_2 - 2.5e-05 25.0 0.1 4.7e-05 24.2 0.1 1.4 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001009411.2_39522001_2 - 0.068 13.4 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) CbiQ PF02361.14 001008325.1_45722001_1 - 6.7 6.1 11.0 9.1 5.7 11.0 1.1 1 0 0 1 1 1 0 Cobalt transport protein ANP PF00212.16 214260.2_49821001_2 - 2.4e-11 43.4 3.0 3.9e-11 42.8 3.0 1.4 1 0 0 1 1 1 1 Atrial natriuretic peptide 7tm_1 PF00001.19 001009145.1_39723001_1 - 2.9e-57 193.8 14.4 3.6e-57 193.5 14.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001009145.1_39723001_1 - 4.5e-08 32.6 19.7 6.9e-08 32.0 19.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx EPO_TPO PF00758.16 001009269.1_22422001_2 - 2.1e-68 229.2 0.0 2.7e-68 228.9 0.0 1.1 1 0 0 1 1 1 1 Erythropoietin/thrombopoietin 7tm_1 PF00001.19 001009744.1_39525001_1 - 6.3e-52 176.3 22.1 1.1e-51 175.6 20.7 1.9 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001009744.1_39525001_1 - 2.1e-07 30.5 20.4 3.3e-07 29.8 20.4 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Calc_CGRP_IAPP PF00214.17 213742.1_49822001_3 - 4.3e-46 156.1 0.1 5.3e-46 155.8 0.1 1.1 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family GCSF PF16647.3 001009227.1_22423001_3 - 3.6e-87 289.6 2.8 5e-87 289.2 2.8 1.2 1 0 0 1 1 1 1 Granulocyte colony-stimulating factor IL6 PF00489.15 001009227.1_22423001_3 - 0.046 13.2 0.0 0.085 12.3 0.0 1.4 1 1 0 1 1 1 0 Interleukin-6/G-CSF/MGF family LEAP-2 PF07359.9 213788.1_49822001_2 - 8.4e-43 144.0 3.8 1.1e-42 143.5 3.8 1.2 1 0 0 1 1 1 1 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) EB PF01683.16 213788.1_49822001_2 - 0.006 16.7 0.2 0.011 15.8 0.2 1.5 1 0 0 1 1 1 1 EB module 7tm_1 PF00001.19 001009215.1_39523001_1 - 1.2e-55 188.5 14.1 1.6e-55 188.1 14.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001009215.1_39523001_1 - 2.3e-09 36.9 14.9 3.7e-09 36.2 14.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001009215.1_39523001_1 - 0.00022 20.5 15.1 0.00031 20.0 15.1 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF3810 PF12725.5 001009215.1_39523001_1 - 0.22 10.7 4.2 0.46 9.7 4.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Iso_dh PF00180.18 001009276.1_39525001_2 - 1.6e-76 257.6 0.0 2e-76 257.3 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase SH3_1 PF00018.26 104225.1_26225120_2 - 5e-15 54.7 0.9 6.5e-15 54.3 0.0 1.7 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 104225.1_26225120_2 - 6e-15 54.7 0.6 1.7e-14 53.2 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.15 104225.1_26225120_2 - 1.1e-10 40.9 0.4 2.2e-10 39.9 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain Ysc84 PF04366.10 104225.1_26225120_3 - 6e-40 135.8 0.0 8.6e-40 135.3 0.0 1.2 1 0 0 1 1 1 1 Las17-binding protein actin regulator FAM27 PF15832.3 103833.1_26224120_1 - 0.00068 20.0 23.3 0.00068 20.0 23.3 1.8 2 0 0 2 2 2 1 FAM27 D and E protein family FAM27 PF15832.3 103833.1_26224120_2 - 7.8e-39 132.0 30.8 1.4e-38 131.2 30.8 1.4 1 0 0 1 1 1 1 FAM27 D and E protein family DUF3915 PF13054.4 103833.1_26224120_2 - 0.71 9.7 5.0 1.3 8.9 5.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF1725 PF08333.9 104034.1_26222120_1 - 1.5e-06 27.5 0.5 2.6e-06 26.8 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) MtrC PF04211.11 104034.1_26222120_1 - 0.083 11.8 1.3 0.11 11.4 1.3 1.1 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit C 7tm_1 PF00001.19 104034.1_26222120_2 - 1.9e-06 27.2 0.1 2.5e-06 26.8 0.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Acetyltransf_1 PF00583.23 001047127.1_29622001_1 - 1.1e-10 41.6 0.0 1.5e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.5 001047127.1_29622001_1 - 3.3e-06 26.9 0.0 4.2e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.5 001047127.1_29622001_1 - 0.00073 19.8 0.0 0.0012 19.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain 7tm_1 PF00001.19 001040447.1_39723001_1 - 1.4e-55 188.3 14.9 1.4e-55 188.3 14.9 1.7 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) TrbC PF04956.11 001040447.1_39723001_1 - 0.54 10.4 5.4 1.7 8.8 0.3 2.6 2 0 0 2 2 2 0 TrbC/VIRB2 family GnRH PF00446.15 001034202.1_29621001_1 - 0.0015 18.6 10.7 0.0015 18.6 10.7 2.2 3 0 0 3 3 3 1 Gonadotropin-releasing hormone Hormone_1 PF00103.18 001032994.1_32322001_1 - 8.3e-77 257.6 0.8 9.7e-77 257.4 0.8 1.0 1 0 0 1 1 1 1 Somatotropin hormone family KIAA1430 PF13879.4 001032994.1_32322001_1 - 0.093 13.4 0.3 1.1 9.9 0.0 2.1 2 0 0 2 2 2 0 KIAA1430 homologue SNARE_assoc PF09335.9 001012358.1_45725001_3 - 3.1e-21 75.9 6.2 3.1e-21 75.9 6.2 2.5 3 0 0 3 3 3 1 SNARE associated Golgi protein HSP20 PF00011.19 001032937.1_29624001_1 - 2.6e-16 59.5 0.0 4.2e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Glyco_transf_29 PF00777.16 001037300.1_39723001_1 - 1.2e-73 247.7 0.0 1.6e-73 247.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Edc3_linker PF16598.3 001037300.1_39723001_2 - 0.62 10.6 7.1 0.068 13.7 2.5 1.8 2 0 0 2 2 2 0 Linker region of enhancer of mRNA-decapping protein 3 Cys_knot PF00007.20 001071803.1_39721001_1 - 2.2e-36 124.2 5.0 2.6e-36 124.0 5.0 1.0 1 0 0 1 1 1 1 Cystine-knot domain TAS2R PF05296.11 001013915.1_45722001_1 - 4.6e-71 239.3 32.0 6.1e-71 238.9 32.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001040420.1_29623001_1 - 3.2e-54 183.8 14.8 3.2e-54 183.8 14.8 1.9 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) TrbC PF04956.11 001040420.1_29623001_1 - 0.25 11.5 4.3 2.1 8.5 0.3 2.7 2 0 0 2 2 2 0 TrbC/VIRB2 family DUF2909 PF11137.6 001040420.1_29623001_1 - 0.37 10.6 8.9 3.3 7.6 3.4 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2909) SpoIIM PF01944.15 001040420.1_29623001_1 - 4.3 7.2 11.5 0.2 11.6 2.5 2.5 2 1 0 2 2 2 0 Stage II sporulation protein M Kringle PF00051.16 001043075.1_29626001_3 - 5.8e-148 481.4 68.0 7.2e-30 103.0 9.1 5.4 5 0 0 5 5 5 5 Kringle domain Trypsin PF00089.24 001043075.1_29626001_3 - 1.6e-64 217.6 0.0 2.8e-64 216.8 0.0 1.4 1 0 0 1 1 1 1 Trypsin PAN_1 PF00024.24 001043075.1_29626001_3 - 3.2e-13 49.3 1.5 3.2e-13 49.3 1.5 2.3 2 0 0 2 2 2 1 PAN domain DUF1986 PF09342.9 001043075.1_29626001_3 - 2.1e-08 34.4 0.0 3.5e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 001043075.1_29626001_3 - 9.6e-07 29.7 0.0 2.2e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF3719 PF12516.6 001043075.1_29626001_3 - 0.0019 17.8 4.3 0.17 11.5 0.0 4.2 4 0 0 4 4 4 1 Protein of unknown function (DUF3719) TAP42 PF04177.10 015777.2_32923001_1 - 2.6e-81 273.1 11.8 3e-81 272.9 11.8 1.0 1 0 0 1 1 1 1 TAP42-like family ANP PF00212.16 001009479.1_39521001_1 - 4.2e-15 55.5 7.8 7.7e-15 54.6 7.8 1.5 1 0 0 1 1 1 1 Atrial natriuretic peptide Defensin_beta PF00711.17 001037509.1_45721001_1 - 3e-06 27.0 9.2 3e-06 27.0 9.2 1.5 2 0 0 2 2 2 1 Beta defensin Nop25 PF09805.7 133800.3_32924001_1 - 1.4e-16 61.0 11.2 1.4e-16 61.0 11.2 2.0 2 0 0 2 2 2 1 Nucleolar protein 12 (25kDa) Glyco_transf_29 PF00777.16 001037296.1_39723001_1 - 1.9e-76 256.9 0.1 2.5e-76 256.5 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Cys_knot PF00007.20 001032983.1_32321001_2 - 6.4e-32 109.8 14.7 7.7e-32 109.6 14.7 1.1 1 0 0 1 1 1 1 Cystine-knot domain Xylo_C PF12529.6 001037289.1_39726001_1 - 7.1e-70 234.2 0.0 1.1e-69 233.6 0.0 1.3 1 0 0 1 1 1 1 Xylosyltransferase C terminal Branch PF02485.19 001037289.1_39726001_1 - 6.9e-50 169.7 1.4 9.7e-50 169.2 1.4 1.2 1 0 0 1 1 1 1 Core-2/I-Branching enzyme 7tm_1 PF00001.19 001009871.1_22423001_1 - 7.2e-39 133.5 13.3 9.6e-39 133.1 13.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 001009871.1_22423001_1 - 3.4e-06 26.4 1.1 3.4e-06 26.4 1.1 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srt PF10321.7 001009871.1_22423001_1 - 8.3e-05 21.6 20.0 0.028 13.2 8.0 2.6 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srt 7TM_GPCR_Srsx PF10320.7 001009871.1_22423001_1 - 0.0037 16.5 8.2 0.2 10.9 3.9 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001009871.1_22423001_1 - 0.04 13.5 10.1 0.24 10.9 10.1 1.9 1 1 0 1 1 1 0 Olfactory receptor DPPIV_N PF00930.19 001034161.1_39725001_1 - 3e-111 371.5 0.0 4.6e-111 370.9 0.0 1.3 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.19 001034161.1_39725001_1 - 3e-39 134.5 0.0 5.7e-39 133.6 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family PD40 PF07676.10 001034161.1_39725001_1 - 4.1e-08 32.8 0.7 0.058 13.2 0.0 4.4 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat DLH PF01738.16 001034161.1_39725001_1 - 0.013 15.0 0.1 0.056 12.9 0.1 1.9 2 0 0 2 2 2 0 Dienelactone hydrolase family DUF872 PF05915.10 001034161.1_39725001_1 - 0.024 14.7 0.0 0.057 13.5 0.0 1.5 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) Abhydrolase_2 PF02230.14 001034161.1_39725001_1 - 0.15 11.7 0.2 6.7 6.3 0.0 2.2 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase 2-oxoacid_dh PF00198.21 214397.1_49826001_2 - 1.3e-80 270.0 0.4 2e-80 269.4 0.4 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.20 214397.1_49826001_2 - 4.2e-22 77.6 0.4 7.2e-22 76.9 0.4 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.4 214397.1_49826001_2 - 0.0018 17.9 0.0 0.0041 16.8 0.0 1.5 1 0 0 1 1 1 1 Biotin-lipoyl like GCV_H PF01597.17 214397.1_49826001_2 - 0.064 13.0 0.3 0.12 12.1 0.3 1.4 1 0 0 1 1 1 0 Glycine cleavage H-protein IL15 PF02372.13 001044731.1_29622001_1 - 6.1e-55 184.8 4.4 6.1e-55 184.8 4.4 1.4 2 0 0 2 2 2 1 Interleukin 15 Defensin_beta_2 PF13841.4 001034196.1_29621001_3 - 3.5e-11 43.2 10.6 4.3e-11 42.9 10.6 1.1 1 0 0 1 1 1 1 Beta defensin Glyco_transf_29 PF00777.16 001037303.1_39723001_1 - 3.6e-78 262.5 0.0 4.5e-78 262.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Phage_portal_2 PF05136.11 001037303.1_39723001_1 - 0.089 11.8 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Phage portal protein, lambda family 7tm_1 PF00001.19 001033928.1_39723001_1 - 3.1e-87 292.1 8.9 3.8e-87 291.8 8.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001033928.1_39723001_1 - 1.9e-17 63.4 21.9 1.7e-13 50.4 15.2 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 001033928.1_39723001_1 - 3.2e-05 23.3 23.0 0.0086 15.3 15.9 2.3 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 001033928.1_39723001_1 - 0.00021 21.0 11.3 0.00021 21.0 11.3 2.3 2 1 0 2 2 2 1 Olfactory receptor DUF2207 PF09972.7 001033928.1_39723001_1 - 0.0075 15.0 6.6 0.042 12.5 0.0 2.9 2 1 1 3 3 3 1 Predicted membrane protein (DUF2207) Rifin_STEVOR PF02009.14 001033928.1_39723001_1 - 0.023 14.5 1.1 0.051 13.3 1.1 1.5 1 0 0 1 1 1 0 Rifin/stevor family DUF3806 PF12713.5 001033928.1_39723001_1 - 0.11 12.2 0.6 4.4 7.0 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3806) CcmH PF03918.12 001033928.1_39723001_1 - 0.12 11.5 0.3 0.63 9.2 0.0 2.1 2 0 0 2 2 2 0 Cytochrome C biogenesis protein EphA2_TM PF14575.4 001033928.1_39723001_1 - 0.39 11.4 1.5 5.5 7.7 0.0 3.2 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain DUF912 PF06024.10 001033928.1_39723001_1 - 0.53 10.5 7.1 2.2 8.5 0.6 3.4 3 1 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Virul_fac_BrkB PF03631.13 001033928.1_39723001_1 - 4.3 6.7 14.0 0.19 11.2 1.6 2.9 3 0 0 3 3 3 0 Virulence factor BrkB Cys_knot PF00007.20 001032971.1_32322001_2 - 1.4e-31 108.7 1.5 1.9e-31 108.3 1.5 1.2 1 0 0 1 1 1 1 Cystine-knot domain IL17_R_N PF15037.4 001034029.1_32924001_3 - 6.7e-119 397.3 4.1 5.2e-117 391.1 4.1 2.3 1 1 0 1 1 1 1 Interleukin-17 receptor extracellular region SEFIR PF08357.9 001034029.1_32924001_3 - 5e-26 91.6 0.0 9.8e-26 90.7 0.0 1.5 1 0 0 1 1 1 1 SEFIR domain zf-DHHC PF01529.18 001039100.1_45724001_3 - 2.3e-26 92.3 2.4 4.7e-26 91.3 2.4 1.5 1 0 0 1 1 1 1 DHHC palmitoyltransferase Herpes_LMP2 PF07415.9 001039100.1_45724001_3 - 0.007 15.1 5.9 0.011 14.4 5.9 1.2 1 0 0 1 1 1 1 Gammaherpesvirus latent membrane protein (LMP2) protein RRM_1 PF00076.20 001280128.1_39726001_2 - 4.2e-31 106.5 0.0 1.6e-15 56.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOPS PF08075.9 001280128.1_39726001_2 - 1e-26 92.7 1.4 2.3e-26 91.6 1.4 1.6 1 0 0 1 1 1 1 NOPS (NUC059) domain RRM_7 PF16367.3 001280128.1_39726001_2 - 0.00011 22.1 0.0 0.0021 18.0 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif RRM_occluded PF16842.3 001280128.1_39726001_2 - 0.02 14.6 0.0 0.065 13.0 0.0 1.8 2 0 0 2 2 2 0 Occluded RNA-recognition motif RRM_5 PF13893.4 001280128.1_39726001_2 - 0.05 13.1 0.0 0.19 11.2 0.0 2.0 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GvpL_GvpF PF06386.9 001280128.1_39726001_2 - 2.6 7.8 17.1 4.5 7.0 17.1 1.3 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF WRNPLPNID PF15017.4 001197061.1_37923001_1 - 1.7e-20 73.5 2.1 6.1e-17 62.1 0.3 2.2 1 1 1 2 2 2 2 Putative WW-binding domain and destruction box RRM_1 PF00076.20 001194913.1_29626001_3 - 5.3e-31 106.1 0.0 1.8e-15 56.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOPS PF08075.9 001194913.1_29626001_3 - 1.3e-26 92.4 1.4 2.6e-26 91.4 1.4 1.6 1 0 0 1 1 1 1 NOPS (NUC059) domain RRM_7 PF16367.3 001194913.1_29626001_3 - 0.00015 21.7 0.0 0.0024 17.8 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif RRM_occluded PF16842.3 001194913.1_29626001_3 - 0.025 14.3 0.0 0.075 12.8 0.0 1.7 2 0 0 2 2 2 0 Occluded RNA-recognition motif RRM_5 PF13893.4 001194913.1_29626001_3 - 0.037 13.5 0.0 0.22 11.0 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PAS_7 PF12860.5 001194913.1_29626001_3 - 1.7 8.7 13.2 0.48 10.5 2.0 2.4 2 0 0 2 2 2 0 PAS fold GvpL_GvpF PF06386.9 001194913.1_29626001_3 - 3.2 7.5 17.1 5.3 6.8 17.1 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Pkinase_Tyr PF07714.15 001261636.1_29625001_3 - 6.7e-88 294.2 0.0 8.5e-88 293.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001261636.1_29625001_3 - 2.3e-44 151.6 0.0 3.4e-44 151.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 001261636.1_29625001_3 - 1.7e-24 85.5 0.0 3.2e-24 84.7 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 001261636.1_29625001_3 - 2.6e-13 49.2 0.0 4.5e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 001261636.1_29625001_3 - 5.6e-08 32.4 0.0 1.1e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001261636.1_29625001_3 - 1.9e-06 27.3 0.0 3.8e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain APH PF01636.21 001261636.1_29625001_3 - 0.059 13.2 0.0 0.2 11.4 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family WRNPLPNID PF15017.4 001133413.1_43524001_1 - 1.4e-21 77.0 1.1 8.4e-18 64.9 0.1 2.6 2 1 1 3 3 3 2 Putative WW-binding domain and destruction box ETRAMP PF09716.8 001133413.1_43524001_3 - 0.00029 20.7 0.2 0.00056 19.8 0.2 1.5 1 1 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) Holin_BhlA PF10960.6 001133413.1_43524001_3 - 0.91 9.4 5.6 0.23 11.3 1.1 2.2 2 0 0 2 2 2 0 BhlA holin family CutA1 PF03091.13 104458.1_32922120_1 - 1.3e-22 79.3 0.0 1.9e-22 78.8 0.0 1.2 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein CutA1 PF03091.13 104458.1_32922120_2 - 3.9e-10 39.3 0.5 5.8e-10 38.8 0.5 1.2 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein RhoGAP PF00620.25 109847.1_32929120_2 - 2.3e-47 160.5 0.1 4e-47 159.7 0.1 1.4 1 0 0 1 1 1 1 RhoGAP domain Gasdermin PF04598.10 040315.2_32922120_1 - 4.7e-08 32.3 0.0 5.6e-08 32.1 0.0 1.0 1 0 0 1 1 1 1 Gasdermin family HTH_25 PF13413.4 040315.2_32922120_3 - 0.058 13.1 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain W2 PF02020.16 001245007.1_49824001_3 - 5.1e-21 74.5 6.8 1.2e-20 73.3 4.4 2.7 2 1 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon DAZAP2 PF11029.6 001139476.2_49822001_3 - 1.2e-43 149.0 11.4 1.2e-43 149.0 11.4 1.6 2 0 0 2 2 2 1 DAZ associated protein 2 (DAZAP2) Synaptobrevin PF00957.19 001243593.1_49826001_1 - 7.2e-30 102.5 1.1 1.3e-29 101.6 1.1 1.5 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.4 001243593.1_49826001_1 - 3.8e-26 90.8 2.3 4.1e-26 90.7 0.6 2.0 2 0 0 2 2 2 1 Regulated-SNARE-like domain IlvGEDA_leader PF08046.9 001243593.1_49826001_1 - 1.2 8.4 6.7 2.7 7.4 6.7 1.5 1 0 0 1 1 1 0 IlvGEDA operon leader peptide DiSB-ORF2_chro PF16506.3 001243593.1_49826001_2 - 0.016 15.1 1.1 0.029 14.3 1.1 1.4 1 0 0 1 1 1 0 Putative virion glycoprotein of insect viruses IRF-3 PF10401.7 001253352.1_49823001_3 - 1.6e-65 220.2 0.1 2e-65 219.8 0.1 1.1 1 0 0 1 1 1 1 Interferon-regulatory factor 3 IRF PF00605.15 001253352.1_49823001_3 - 1.2e-42 144.3 0.2 1.8e-42 143.7 0.2 1.2 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor MH2 PF03166.12 001253352.1_49823001_3 - 0.012 15.7 0.0 0.018 15.1 0.0 1.2 1 0 0 1 1 1 0 MH2 domain zf-C2H2 PF00096.24 001097489.1_49823001_1 - 7.8e-17 60.6 20.9 2.5e-06 27.5 2.4 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001097489.1_49823001_1 - 1.5e-11 44.1 7.5 2.5e-07 30.7 1.1 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 001097489.1_49823001_1 - 5.1e-09 36.1 20.2 0.00085 19.8 1.8 4.0 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.5 001097489.1_49823001_1 - 0.00018 21.7 7.2 0.0023 18.1 0.4 3.0 2 0 0 2 2 2 1 Zinc-finger of C2H2 type FOXP-CC PF16159.3 001097489.1_49823001_1 - 0.00069 20.1 3.6 0.15 12.6 0.1 2.7 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-C2H2_aberr PF17017.3 001097489.1_49823001_1 - 0.033 14.2 4.6 1.5 8.8 0.1 2.2 2 0 0 2 2 2 0 Aberrant zinc-finger zf-C2H2_6 PF13912.4 001097489.1_49823001_1 - 0.047 13.5 1.0 0.047 13.5 1.0 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger IBR PF01485.19 001097489.1_49823001_1 - 2.4 8.3 6.7 9.9 6.3 6.7 1.9 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain zf-C2H2_jaz PF12171.6 001097489.1_49823001_1 - 6.1 7.1 6.9 7 7.0 0.1 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Melibiase_2 PF16499.3 001123222.1_49823001_1 - 4.1e-165 548.9 0.1 4.6e-165 548.7 0.1 1.0 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase PF02065.16 001123222.1_49823001_1 - 0.00074 18.4 0.1 0.0013 17.7 0.1 1.3 1 0 0 1 1 1 1 Melibiase Prokineticin PF06607.9 001172586.1_49821001_1 - 1.2e-45 153.6 7.9 1.4e-45 153.5 7.9 1.0 1 0 0 1 1 1 1 Prokineticin DUF2362 PF10154.7 001243412.1_49825001_2 - 4e-217 722.0 8.1 4.8e-217 721.7 8.1 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2362) 7tm_1 PF00001.19 001038229.1_49822001_1 - 1.7e-35 122.4 3.9 2.2e-35 122.0 3.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001038229.1_49822001_1 - 4.4e-08 32.7 0.4 5.5e-08 32.4 0.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001038229.1_49822001_1 - 7.3e-07 28.6 0.7 9.4e-07 28.3 0.7 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Serpentine_r_xa PF03383.13 001038229.1_49822001_1 - 0.056 13.3 0.3 0.088 12.6 0.3 1.3 1 0 0 1 1 1 0 Caenorhabditis serpentine receptor-like protein, class xa Ribonuclease_3 PF00636.24 001197194.1_49829001_2 - 4.2e-70 232.9 0.0 1.2e-43 147.9 0.0 3.6 2 1 0 2 2 2 2 Ribonuclease III domain PAZ PF02170.20 001197194.1_49829001_2 - 1.8e-39 134.6 0.6 8.2e-39 132.4 0.2 2.3 2 0 0 2 2 2 1 PAZ domain Dicer_dimer PF03368.12 001197194.1_49829001_2 - 4.2e-25 87.6 0.0 1.9e-24 85.5 0.0 2.2 2 0 0 2 2 2 1 Dicer dimerisation domain Ribonucleas_3_3 PF14622.4 001197194.1_49829001_2 - 1.2e-24 86.8 0.0 1.6e-16 60.5 0.0 3.6 3 1 0 3 3 3 2 Ribonuclease-III-like Helicase_C PF00271.29 001197194.1_49829001_2 - 7.9e-18 64.7 0.1 3.1e-17 62.8 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.27 001197194.1_49829001_2 - 7e-13 48.6 0.0 1.8e-12 47.3 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.13 001197194.1_49829001_2 - 2.6e-12 47.0 0.0 6.6e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit dsrm PF00035.24 001197194.1_49829001_2 - 0.067 13.8 0.0 0.25 11.9 0.0 2.0 1 0 0 1 1 1 0 Double-stranded RNA binding motif TNF PF00229.16 001112690.1_49823001_1 - 2e-11 43.8 0.0 3.1e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1-set PF07654.13 001243319.1_49822001_2 - 4.4e-28 97.5 0.3 3.3e-27 94.6 0.1 2.2 2 0 0 2 2 2 1 Immunoglobulin C1-set domain V-set PF07686.15 001243319.1_49822001_2 - 4.4e-21 75.0 0.2 1.4e-20 73.3 0.0 1.9 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001243319.1_49822001_2 - 1.4e-10 41.5 3.7 0.00015 22.1 0.2 3.3 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001243319.1_49822001_2 - 2.9e-09 36.8 5.3 4.2e-05 23.5 1.2 2.7 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001243319.1_49822001_2 - 6.5e-08 32.4 0.2 0.00027 20.8 0.0 2.9 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 001243319.1_49822001_2 - 1.2e-06 28.6 1.4 0.053 13.8 0.2 2.6 2 1 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001243319.1_49822001_2 - 0.00017 21.4 0.7 0.00051 19.9 0.2 1.9 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain MTHFR PF02219.15 001243319.1_49822001_2 - 0.13 11.4 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 Methylenetetrahydrofolate reductase RHIM PF12721.5 001315738.2_49826001_2 - 3.1e-09 37.0 8.4 3.1e-09 37.0 8.4 3.7 3 0 0 3 3 3 1 RIP homotypic interaction motif TIR_2 PF13676.4 001315738.2_49826001_2 - 0.0061 16.7 0.0 0.018 15.2 0.0 1.8 2 0 0 2 2 2 1 TIR domain adh_short PF00106.23 001315746.1_49823001_1 - 1.6e-32 112.4 0.0 8.1e-26 90.5 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.4 001315746.1_49823001_1 - 6.3e-24 84.7 0.0 4e-17 62.4 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001315746.1_49823001_1 - 1.3e-07 31.6 0.0 1.9e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.19 001315746.1_49823001_1 - 0.00011 21.7 0.0 0.00023 20.6 0.0 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Kinesin PF00225.21 001243019.1_49825001_3 - 3.1e-93 312.2 0.0 5.8e-93 311.3 0.0 1.4 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.3 001243019.1_49825001_3 - 1.7e-20 73.3 0.0 2.9e-20 72.6 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding HHH_3 PF12836.5 001243019.1_49825001_3 - 1.5e-11 44.2 0.0 7.6e-11 42.0 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_6 PF14579.4 001243019.1_49825001_3 - 7.4e-05 22.8 0.0 0.00023 21.2 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.4 001243019.1_49825001_3 - 0.064 13.8 0.2 5.1 7.7 0.0 2.7 3 0 0 3 3 3 0 Helix-hairpin-helix domain Sulfate_transp PF00916.18 001135966.1_49826001_3 - 2.5e-96 322.6 13.5 3.2e-96 322.3 13.5 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.19 001135966.1_49826001_3 - 1.9e-10 40.3 0.0 2.9e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.4 001135966.1_49826001_3 - 0.0063 16.7 0.2 0.017 15.3 0.2 1.7 1 0 0 1 1 1 1 STAS domain FGF-BP1 PF06473.10 001258356.1_49823001_2 - 1.9e-61 207.7 0.0 2.3e-61 207.5 0.0 1.1 1 0 0 1 1 1 1 FGF binding protein 1 (FGF-BP1) Scramblase PF03803.13 001246213.1_49822001_1 - 2.9e-96 320.9 0.0 3.4e-96 320.7 0.0 1.0 1 0 0 1 1 1 1 Scramblase Alpha-amylase PF00128.22 001123042.1_49825001_1 - 2.4e-84 283.6 1.4 3.3e-84 283.2 1.4 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain SLC3A2_N PF16028.3 001123042.1_49825001_1 - 0.00051 19.4 0.2 0.0011 18.4 0.2 1.5 1 0 0 1 1 1 1 Solute carrier family 3 member 2 N-terminus HECT PF00632.23 001198924.1_49829001_3 - 1.9e-104 349.3 0.0 2.9e-104 348.7 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) HECW_N PF16562.3 001198924.1_49829001_3 - 7.2e-59 196.7 0.0 1.3e-58 195.9 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 WW PF00397.24 001198924.1_49829001_3 - 3.1e-18 65.3 0.4 5.7e-10 38.8 0.3 2.5 2 0 0 2 2 2 2 WW domain C2 PF00168.28 001198924.1_49829001_3 - 6.3e-12 45.6 0.0 1.8e-11 44.1 0.0 1.8 2 0 0 2 2 2 1 C2 domain Cep57_CLD PF14073.4 001198924.1_49829001_3 - 0.058 13.3 2.3 0.06 13.2 0.4 2.0 2 0 0 2 2 2 0 Centrosome localisation domain of Cep57 RFXA_RFXANK_bdg PF15289.4 001198924.1_49829001_3 - 0.083 13.1 0.1 0.21 11.8 0.1 1.7 1 0 0 1 1 1 0 Regulatory factor X-associated C-terminal binding domain EnY2 PF10163.7 001243454.1_49822001_1 - 2.4e-35 120.6 0.8 3.3e-35 120.2 0.8 1.2 1 0 0 1 1 1 1 Transcription factor e(y)2 Ribosomal_L37e PF01907.17 001243603.1_49821001_3 - 8.9e-27 92.9 15.1 1.6e-26 92.1 15.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.5 001243603.1_49821001_3 - 0.01 15.7 1.6 0.016 15.1 1.6 1.2 1 0 0 1 1 1 0 Double zinc ribbon FeS PF04060.11 001243603.1_49821001_3 - 1 8.9 4.0 0.81 9.3 0.7 2.1 2 0 0 2 2 2 0 Putative Fe-S cluster CSD PF00313.20 001315786.1_49822001_1 - 9.7e-17 60.5 0.1 2.2e-16 59.3 0.1 1.6 1 1 0 1 1 1 1 'Cold-shock' DNA-binding domain zf-CCHC PF00098.21 001315786.1_49822001_1 - 6.6e-05 22.7 2.7 6.6e-05 22.7 2.7 2.6 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_4 PF14392.4 001315786.1_49822001_1 - 1 9.0 14.3 0.51 9.9 1.8 2.5 2 0 0 2 2 2 0 Zinc knuckle ETS_PEA3_N PF04621.11 001243025.1_49829001_1 - 8.5e-162 538.7 20.8 1.1e-161 538.3 20.8 1.2 1 0 0 1 1 1 1 PEA3 subfamily ETS-domain transcription factor N terminal domain Ets PF00178.20 001243025.1_49829001_1 - 1.8e-37 127.5 0.2 3.4e-37 126.6 0.2 1.5 1 0 0 1 1 1 1 Ets-domain Prenyltrans PF00432.19 001244680.1_49826001_2 - 7.2e-56 185.5 16.5 1.1e-11 44.1 0.2 5.6 5 0 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.4 001244680.1_49826001_2 - 0.0017 17.4 0.0 0.5 9.3 0.0 2.8 1 1 2 3 3 3 3 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.4 001244680.1_49826001_2 - 0.028 13.4 0.0 2.2 7.2 0.0 2.5 1 1 1 2 2 2 0 Squalene-hopene cyclase N-terminal domain Na_Pi_cotrans PF02690.13 001044623.1_49826001_2 - 1.2e-39 135.5 16.9 7.5e-25 87.5 6.1 2.5 2 0 0 2 2 2 2 Na+/Pi-cotransporter Peptidase_M10 PF00413.22 001166308.1_49824001_3 - 8.6e-62 207.5 0.0 1.6e-61 206.6 0.0 1.5 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 001166308.1_49824001_3 - 4.9e-47 157.5 11.8 1.9e-14 53.2 0.3 4.6 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.16 001166308.1_49824001_3 - 5.8e-12 45.5 0.1 1e-11 44.7 0.1 1.4 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.22 001166308.1_49824001_3 - 0.00026 20.5 0.0 0.13 11.7 0.0 2.6 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Reprolysin_5 PF13688.4 001166308.1_49824001_3 - 0.034 14.2 0.0 0.056 13.4 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 001166308.1_49824001_3 - 0.041 14.3 0.0 0.075 13.4 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 001166308.1_49824001_3 - 0.056 13.0 0.0 0.089 12.3 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.3 001166308.1_49824001_3 - 0.089 11.8 0.6 0.16 11.1 0.0 1.7 2 0 0 2 2 2 0 Met-zincin Mitoc_L55 PF09776.7 001244965.1_49822001_2 - 1e-54 183.1 0.7 1.3e-54 182.8 0.7 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L55 VWA_2 PF13519.4 001195327.1_49827001_1 - 0.0001 22.8 0.0 0.00029 21.3 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain Het-C PF07217.9 001195327.1_49827001_1 - 0.00091 17.7 0.0 0.0013 17.2 0.0 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C BLM_N PF16202.3 001123084.2_49829001_1 - 8.7e-172 571.2 38.7 8.7e-172 571.2 38.7 2.7 3 1 0 3 3 3 1 N-terminal region of Bloom syndrome protein BDHCT_assoc PF16204.3 001123084.2_49829001_1 - 4e-117 389.5 11.3 4e-117 389.5 11.3 3.0 2 1 0 2 2 2 1 BDHCT-box associated domain on Bloom syndrome protein BDHCT PF08072.9 001123084.2_49829001_1 - 7.5e-21 73.8 4.9 1.7e-20 72.7 4.9 1.6 1 0 0 1 1 1 1 BDHCT (NUC031) domain DEAD PF00270.27 001123084.2_49829001_1 - 4.9e-20 71.9 0.0 1.1e-19 70.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.3 001123084.2_49829001_1 - 6.2e-17 61.9 4.3 3.6e-16 59.5 4.3 2.5 1 0 0 1 1 1 1 RecQ zinc-binding Helicase_C PF00271.29 001123084.2_49829001_1 - 1.5e-15 57.4 0.0 1.1e-14 54.6 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain RQC PF09382.8 001123084.2_49829001_1 - 2e-15 56.4 0.0 4.2e-15 55.4 0.0 1.6 1 0 0 1 1 1 1 RQC domain HRDC PF00570.21 001123084.2_49829001_1 - 2.9e-12 46.2 0.0 5.9e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 HRDC domain ResIII PF04851.13 001123084.2_49829001_1 - 0.0023 17.8 0.1 0.014 15.3 0.0 2.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit eIF-6 PF01912.16 001243577.1_49823001_2 - 1.1e-79 266.3 0.5 2.9e-79 264.9 0.1 1.7 2 0 0 2 2 2 1 eIF-6 family His_Phos_2 PF00328.20 001244740.1_49825001_3 - 5.8e-34 117.9 0.1 1.2e-30 107.1 0.0 2.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) HLH PF00010.24 001243602.1_49822001_2 - 6.2e-10 38.8 0.0 1.2e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Guanylate_kin PF00625.19 213750.1_49824001_1 - 5.6e-47 159.6 0.1 1e-46 158.8 0.1 1.5 1 0 0 1 1 1 1 Guanylate kinase VGCC_beta4Aa_N PF12052.6 213750.1_49824001_1 - 4.3e-22 77.8 6.1 1.1e-21 76.5 6.1 1.8 1 0 0 1 1 1 1 Voltage gated calcium channel subunit beta domain 4Aa N terminal SH3_1 PF00018.26 213750.1_49824001_1 - 0.0017 17.8 0.0 0.0058 16.1 0.0 1.9 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 213750.1_49824001_1 - 0.013 15.2 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain SH3_2 PF07653.15 213750.1_49824001_1 - 0.03 13.9 0.0 0.068 12.7 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain Peptidase_M28 PF04389.15 001243636.1_49824001_1 - 1.5e-45 155.2 0.0 2e-45 154.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M28 Na_sulph_symp PF00939.17 001244717.1_49825001_3 - 1.1e-158 529.0 16.6 1.4e-158 528.7 16.6 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.14 001244717.1_49825001_3 - 6.9e-40 137.0 15.2 7.9e-22 77.7 0.0 3.0 2 1 1 3 3 3 2 Citrate transporter DUF4598 PF15370.4 001244659.1_49823001_3 - 5.1e-14 52.6 2.8 5.1e-14 52.6 2.8 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4598) Sigma70_r1_1 PF03979.12 001244659.1_49823001_3 - 0.12 12.3 5.0 0.066 13.1 2.8 1.7 2 0 0 2 2 2 0 Sigma-70 factor, region 1.1 Trypsin PF00089.24 001143711.1_49822001_3 - 9.6e-69 231.4 0.2 1.1e-68 231.2 0.2 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001143711.1_49822001_3 - 2.7e-09 37.9 0.0 3.9e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001143711.1_49822001_3 - 1.8e-06 28.1 0.0 3.1e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) SMAP PF15477.4 001244873.1_49822001_3 - 1.4e-11 45.0 1.5 1.4e-11 45.0 1.5 1.9 2 0 0 2 2 2 1 Small acidic protein family BUD22 PF09073.8 001244873.1_49822001_3 - 0.39 9.9 16.7 0.49 9.5 16.7 1.1 1 0 0 1 1 1 0 BUD22 DUF3408 PF11888.6 001244873.1_49822001_3 - 0.41 10.7 7.2 0.055 13.5 3.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) NOA36 PF06524.10 001244873.1_49822001_3 - 8.5 5.5 12.1 13 4.9 12.1 1.3 1 0 0 1 1 1 0 NOA36 protein Ion_trans PF00520.29 001044596.1_49825001_1 - 9.2e-46 155.9 0.2 1.2e-45 155.5 0.2 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 001044596.1_49825001_1 - 4.1e-32 110.3 0.7 1.9e-31 108.1 0.2 2.3 2 0 0 2 2 2 1 BTB/POZ domain Ion_trans_2 PF07885.14 001044596.1_49825001_1 - 2.5e-10 40.0 4.0 5.5e-10 39.0 4.0 1.6 1 0 0 1 1 1 1 Ion channel BTB_3 PF16017.3 001044596.1_49825001_1 - 0.013 15.5 0.1 0.027 14.4 0.1 1.5 1 0 0 1 1 1 0 BTB/POZ domain Ubiq_cyt_C_chap PF03981.10 001172364.2_49825001_1 - 4.7e-41 140.0 0.1 6.3e-41 139.6 0.1 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone NICE-1 PF15845.3 001172364.2_49825001_2 - 0.094 13.4 2.4 0.19 12.4 2.4 1.5 1 0 0 1 1 1 0 Cysteine-rich C-terminal 1 family Cathelicidins PF00666.15 001123186.1_49822001_1 - 0.0055 16.9 2.4 0.01 16.0 1.7 1.9 1 1 0 1 1 1 1 Cathelicidin BRICHOS PF04089.12 001105311.1_49822001_1 - 1.6e-24 85.7 0.0 2.3e-24 85.1 0.0 1.3 1 0 0 1 1 1 1 BRICHOS domain Complex1_LYR PF05347.13 001185178.1_49822001_3 - 3e-09 36.7 0.0 5.4e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.4 001185178.1_49822001_3 - 0.0017 18.9 0.1 0.0027 18.3 0.1 1.3 1 0 0 1 1 1 1 Complex1_LYR-like NNMT_PNMT_TEMT PF01234.15 001244733.1_49823001_1 - 6.6e-94 313.7 0.0 8.3e-94 313.4 0.0 1.0 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_25 PF13649.4 001244733.1_49823001_1 - 0.0049 17.4 0.0 1.2 9.8 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001244733.1_49823001_1 - 0.0091 16.5 0.0 0.065 13.7 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.4 001244733.1_49823001_1 - 0.02 14.7 0.0 0.051 13.4 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain NodS PF05401.9 001244733.1_49823001_1 - 0.021 14.3 0.0 0.032 13.7 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_12 PF08242.10 001244733.1_49823001_1 - 0.054 14.1 0.0 0.15 12.7 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain NUDIX PF00293.26 001244568.1_49822001_1 - 5.3e-16 58.7 0.1 7.4e-16 58.3 0.1 1.2 1 0 0 1 1 1 1 NUDIX domain FAM110_C PF14160.4 001244271.2_49823001_1 - 8.7e-32 110.4 0.0 1.4e-31 109.7 0.0 1.3 1 0 0 1 1 1 1 Centrosome-associated C terminus FAM110_N PF14161.4 001244271.2_49823001_1 - 1.4e-11 44.5 0.1 2.3e-11 43.8 0.1 1.4 1 0 0 1 1 1 1 Centrosome-associated N terminus DZR PF12773.5 001244271.2_49823001_1 - 0.11 12.4 3.4 0.15 12.0 0.1 2.4 2 0 0 2 2 2 0 Double zinc ribbon LNS2 PF08235.11 001130734.1_49826001_2 - 3.2e-104 347.2 0.0 5.3e-104 346.5 0.0 1.4 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.12 001130734.1_49826001_2 - 6.6e-45 151.2 0.0 1.4e-44 150.1 0.0 1.6 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.3 001130734.1_49826001_2 - 4.2e-33 113.5 0.0 1.1e-32 112.1 0.0 1.8 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain DUF5005 PF16396.3 001130734.1_49826001_2 - 0.14 10.7 0.0 20 3.6 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF5005) RRM_1 PF00076.20 001243555.1_49823001_3 - 1.1e-21 76.2 0.0 1.2e-10 40.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Lon_C PF05362.11 001243220.1_49827001_2 - 1.8e-69 233.2 0.0 4.7e-69 231.9 0.0 1.7 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.14 001243220.1_49827001_2 - 2.4e-31 109.1 1.8 5.5e-31 107.9 1.8 1.7 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.27 001243220.1_49827001_2 - 4e-24 85.4 0.0 1.6e-23 83.4 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.12 001243220.1_49827001_2 - 1.8e-08 34.4 0.0 4.4e-08 33.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.12 001243220.1_49827001_2 - 8.6e-08 32.3 0.0 2.1e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.10 001243220.1_49827001_2 - 3.8e-07 29.5 0.0 1.1e-05 24.7 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus ChlI PF13541.4 001243220.1_49827001_2 - 5.2e-07 29.4 0.1 1.7e-06 27.7 0.0 1.9 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.4 001243220.1_49827001_2 - 1.7e-06 28.4 1.0 1.8e-05 25.0 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_PrkA PF08298.9 001243220.1_49827001_2 - 4e-06 25.8 0.0 7.3e-06 25.0 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain AAA_22 PF13401.4 001243220.1_49827001_2 - 7.2e-05 22.9 0.1 0.0022 18.1 0.0 3.0 2 1 0 2 2 1 1 AAA domain AAA_23 PF13476.4 001243220.1_49827001_2 - 0.00056 20.3 4.7 0.23 11.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.20 001243220.1_49827001_2 - 0.0022 18.2 0.0 0.0049 17.1 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.4 001243220.1_49827001_2 - 0.0025 17.7 0.5 0.011 15.6 0.0 2.3 3 0 0 3 3 2 1 AAA domain IstB_IS21 PF01695.15 001243220.1_49827001_2 - 0.0039 16.8 0.0 0.0086 15.7 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.4 001243220.1_49827001_2 - 0.0059 17.0 0.6 0.031 14.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.16 001243220.1_49827001_2 - 0.012 15.4 3.4 0.77 9.5 0.0 3.3 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea DUF258 PF03193.14 001243220.1_49827001_2 - 0.025 14.4 0.0 0.097 12.4 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function, DUF258 TsaE PF02367.15 001243220.1_49827001_2 - 0.052 13.4 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.4 001243220.1_49827001_2 - 0.058 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.10 001243220.1_49827001_2 - 0.069 12.9 0.0 0.18 11.5 0.0 1.8 1 1 0 1 1 1 0 NACHT domain NB-ARC PF00931.20 001243220.1_49827001_2 - 0.076 11.9 0.9 0.11 11.3 0.0 1.6 2 0 0 2 2 1 0 NB-ARC domain AAA_30 PF13604.4 001243220.1_49827001_2 - 0.094 12.3 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.15 001243220.1_49827001_2 - 0.12 11.3 0.0 0.27 10.1 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_3 PF07726.9 001243220.1_49827001_2 - 0.15 11.8 0.0 0.34 10.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.25 001243220.1_49827001_2 - 0.15 12.4 0.2 0.86 10.0 0.0 2.3 2 0 0 2 2 2 0 ABC transporter Peptidase_S41_N PF11918.6 001243220.1_49827001_2 - 0.4 10.8 2.3 8.1 6.5 0.0 3.0 4 0 0 4 4 2 0 N-terminal domain of Peptidase_S41 in eukaryotic IRBP AAA_11 PF13086.4 001243220.1_49827001_2 - 4.2 6.9 5.9 1.5 8.3 0.0 2.3 2 1 0 2 2 2 0 AAA domain Pkinase PF00069.23 001315708.1_49825001_3 - 7.3e-70 235.2 0.0 8.7e-70 234.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001315708.1_49825001_3 - 3.1e-25 88.8 0.0 4.2e-25 88.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001315708.1_49825001_3 - 0.00033 20.0 0.0 0.0032 16.7 0.0 2.0 1 1 1 2 2 2 1 Kinase-like APH PF01636.21 001315708.1_49825001_3 - 0.004 17.0 0.0 0.019 14.7 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.12 001315708.1_49825001_3 - 0.058 12.6 0.0 0.089 12.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PhyH PF05721.11 001113447.1_49822001_1 - 1e-37 130.3 0.1 1.3e-37 130.0 0.1 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.4 001113447.1_49822001_1 - 0.0017 18.6 0.0 0.13 12.5 0.0 2.3 1 1 1 2 2 2 2 Putative 2OG-Fe(II) oxygenase Orn_Arg_deC_N PF02784.14 001123193.2_49824001_1 - 2.5e-70 236.6 0.0 3.1e-70 236.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001123193.2_49824001_1 - 3.2e-18 65.7 0.0 5.3e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.22 001123193.2_49824001_1 - 8e-06 25.3 0.0 1.6e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel PAF PF15715.3 001244997.1_49824001_3 - 1.8e-34 118.0 2.0 2.9e-34 117.4 2.0 1.3 1 0 0 1 1 1 1 PCNA-associated factor Kunitz_BPTI PF00014.21 001244422.2_49826001_2 - 2.1e-34 117.4 21.8 4.5e-17 61.9 7.4 2.9 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain MANEC PF07502.12 001244422.2_49826001_2 - 1.5e-26 92.3 0.7 1.5e-26 92.3 0.7 2.7 3 0 0 3 3 3 1 MANEC domain Ldl_recept_a PF00057.16 001244422.2_49826001_2 - 7e-09 35.6 12.8 7e-09 35.6 12.8 2.3 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A Spectrin PF00435.19 001243061.1_49828001_3 - 4.2e-73 242.4 22.3 3.4e-25 88.4 6.4 4.3 4 0 0 4 4 4 4 Spectrin repeat CH PF00307.29 001243061.1_49828001_3 - 6.9e-53 177.3 0.0 4.3e-26 91.1 0.0 2.7 2 0 0 2 2 2 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.8 001243061.1_49828001_3 - 3.9e-27 94.0 0.0 1.2e-26 92.5 0.0 1.9 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_1 PF00036.30 001243061.1_49828001_3 - 5.5e-07 28.5 1.4 0.011 15.2 0.4 3.2 3 0 0 3 3 3 2 EF hand CAMSAP_CH PF11971.6 001243061.1_49828001_3 - 2.3e-06 27.2 0.0 8.7e-05 22.2 0.0 2.5 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_8 PF13833.4 001243061.1_49828001_3 - 3.3e-05 23.5 0.7 0.00029 20.4 0.4 2.7 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_7 PF13499.4 001243061.1_49828001_3 - 4.5e-05 23.7 0.1 0.00019 21.7 0.1 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.4 001243061.1_49828001_3 - 8.2e-05 22.1 0.9 0.0076 16.0 0.3 3.6 3 0 0 3 3 3 1 EF-hand domain EF-hand_11 PF08976.9 001243061.1_49828001_3 - 0.041 14.6 0.7 0.29 11.9 0.1 2.7 2 0 0 2 2 2 0 EF-hand domain XisI PF08869.9 001243061.1_49828001_3 - 0.067 13.4 0.6 0.26 11.5 0.6 2.0 1 0 0 1 1 1 0 XisI protein Dak2 PF02734.15 001243061.1_49828001_3 - 0.24 11.1 0.8 13 5.5 0.1 2.8 3 0 0 3 3 3 0 DAK2 domain Uds1 PF15456.4 001243061.1_49828001_3 - 5.9 6.9 9.9 0.99 9.4 2.3 3.2 3 0 0 3 3 3 0 Up-regulated During Septation MRP-S23 PF10484.7 001243813.1_49822001_2 - 8.8e-48 161.6 0.0 1.2e-47 161.2 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S23 MRP-S25 PF13741.4 001243813.1_49822001_2 - 1.4e-06 27.9 0.6 0.0008 18.9 0.0 2.2 1 1 1 2 2 2 2 Mitochondrial ribosomal protein S25 SET PF00856.26 001039747.1_49824001_1 - 3e-20 73.2 0.0 7.6e-20 71.8 0.0 1.7 1 0 0 1 1 1 1 SET domain Pre-SET PF05033.14 001039747.1_49824001_1 - 4.5e-17 62.5 8.1 4.7e-17 62.4 5.2 2.2 2 0 0 2 2 2 1 Pre-SET motif Chromo PF00385.22 001039747.1_49824001_1 - 2.2e-10 40.1 0.8 5.1e-10 39.0 0.8 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain 7tm_1 PF00001.19 001001619.1_49825001_2 - 8.1e-49 166.1 19.2 1.2e-48 165.5 19.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001001619.1_49825001_2 - 1e-06 28.2 21.8 1.4e-06 27.7 21.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001001619.1_49825001_2 - 0.0021 17.3 14.2 0.0021 17.3 14.2 1.8 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Lectin_C PF00059.19 001315794.1_49822001_1 - 2.2e-15 57.2 1.2 2.2e-15 57.2 1.2 1.9 2 0 0 2 2 2 1 Lectin C-type domain UL45 PF05473.10 001315794.1_49822001_1 - 0.0006 19.4 3.3 0.0011 18.5 0.3 2.2 2 0 0 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like Chordopox_A33R PF05966.10 001315794.1_49822001_1 - 0.0043 16.2 0.1 0.006 15.7 0.1 1.2 1 0 0 1 1 1 1 Chordopoxvirus A33R protein DUF1049 PF06305.9 001315794.1_49822001_1 - 0.059 13.1 1.1 0.098 12.4 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) DUF2140 PF09911.7 001315794.1_49822001_1 - 0.19 11.1 0.0 13 5.2 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) HSP70 PF00012.18 001243393.1_49824001_2 - 3e-116 388.9 0.1 3.5e-116 388.6 0.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 001243393.1_49824001_2 - 4.3e-12 45.4 0.0 3.2e-11 42.5 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein Actin PF00022.17 001243393.1_49824001_2 - 0.0027 16.2 0.1 0.13 10.7 0.0 2.3 2 1 0 2 2 2 2 Actin ArAE_2 PF10334.7 001243393.1_49824001_2 - 0.11 12.2 0.0 2.1 8.0 0.0 2.2 2 0 0 2 2 2 0 Aromatic acid exporter family member 2 A_amylase_inhib PF01356.17 001243393.1_49824001_2 - 0.27 11.1 2.3 0.3 11.0 0.4 2.0 2 0 0 2 2 2 0 Alpha amylase inhibitor DUF2370 PF10176.7 001243361.1_49824001_1 - 8.8e-10 38.5 7.4 5.6e-07 29.3 0.0 3.1 1 1 1 3 3 3 3 Protein of unknown function (DUF2370) Comm PF15957.3 001243361.1_49824001_1 - 0.041 14.1 0.1 0.099 12.9 0.1 1.6 1 0 0 1 1 1 0 Commissureless RskA PF10099.7 001243361.1_49824001_1 - 0.14 12.3 7.4 0.23 11.6 7.4 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA RRM_1 PF00076.20 001077221.1_49822001_1 - 8.5e-22 76.6 0.0 1.2e-21 76.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 001077221.1_49822001_1 - 0.033 14.1 0.0 0.056 13.4 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif RRM_occluded PF16842.3 001077221.1_49822001_1 - 0.037 13.8 0.0 0.056 13.2 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif Apt1 PF10351.7 001077221.1_49822001_1 - 0.041 12.6 14.0 0.05 12.3 14.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain MIP-T3 PF10243.7 001077221.1_49822001_1 - 0.15 10.6 9.2 0.17 10.4 9.2 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 NPR3 PF03666.11 001077221.1_49822001_1 - 1.4 7.5 8.0 1.8 7.1 8.0 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.15 001077221.1_49822001_1 - 5.8 5.4 9.3 7.7 5.0 9.3 1.1 1 0 0 1 1 1 0 Presenilin Pneumo_att_G PF05539.9 001077221.1_49822001_1 - 7.6 5.9 10.4 9.7 5.5 10.4 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G FAM110_C PF14160.4 001243479.2_49823001_3 - 1.1e-31 110.0 0.0 1.8e-31 109.4 0.0 1.3 1 0 0 1 1 1 1 Centrosome-associated C terminus FAM110_N PF14161.4 001243479.2_49823001_3 - 1.7e-11 44.2 0.1 2.8e-11 43.5 0.1 1.4 1 0 0 1 1 1 1 Centrosome-associated N terminus DZR PF12773.5 001243479.2_49823001_3 - 0.092 12.7 0.1 0.18 11.7 0.1 1.6 1 0 0 1 1 1 0 Double zinc ribbon 7tm_1 PF00001.19 001011506.1_49823001_3 - 2.5e-38 131.7 12.3 3.6e-38 131.2 12.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srt PF10321.7 001011506.1_49823001_3 - 1.9e-05 23.7 16.5 0.0079 15.0 5.7 2.5 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srt 7TM_GPCR_Srw PF10324.7 001011506.1_49823001_3 - 2.8e-05 23.5 0.5 2.8e-05 23.5 0.5 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.7 001011506.1_49823001_3 - 0.00014 21.2 9.2 0.00022 20.6 8.8 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.7 001011506.1_49823001_3 - 0.0043 16.3 6.5 0.32 10.2 2.2 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001011506.1_49823001_3 - 0.24 11.0 8.6 1.5 8.3 8.6 1.9 1 1 0 1 1 1 0 Olfactory receptor DUF4190 PF13828.4 001011506.1_49823001_3 - 2.9 7.6 7.7 0.35 10.5 1.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4190) ECH_1 PF00378.18 001190175.1_49823001_3 - 2.5e-97 325.0 1.0 3.1e-97 324.7 1.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.3 001190175.1_49823001_3 - 3.5e-37 128.5 2.5 2.5e-34 119.1 0.3 2.1 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.16 001190175.1_49823001_3 - 0.0019 18.0 0.0 0.23 11.2 0.0 2.5 2 0 0 2 2 2 2 Peptidase family S49 DUF2484 PF10658.7 001243437.1_49825001_1 - 1.7 8.8 9.4 3 8.1 0.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2484) Lectin_leg-like PF03388.11 001243437.1_49825001_2 - 5.9e-85 284.1 0.0 7.6e-85 283.8 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family PMP1_2 PF08114.9 001243437.1_49825001_2 - 0.046 13.3 0.3 0.11 12.1 0.3 1.6 1 0 0 1 1 1 0 ATPase proteolipid family ATG_C PF09333.9 001190277.1_49829001_1 - 1.3e-31 108.7 0.1 4.4e-31 107.0 0.1 2.0 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain Chorein_N PF12624.5 001190277.1_49829001_1 - 3.1e-17 62.6 0.0 1.1e-16 60.8 0.0 2.0 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 ATG2_CAD PF13329.4 001190277.1_49829001_1 - 8.7e-08 31.9 0.7 2.7e-07 30.3 0.7 1.9 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif VPS13_C PF16909.3 001190277.1_49829001_1 - 2.1e-05 24.2 0.0 7.1e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal VPS13 PF16908.3 001190277.1_49829001_1 - 0.013 15.2 0.0 0.18 11.5 0.0 2.6 2 0 0 2 2 2 0 Vacuolar sorting-associated protein 13, N-terminal Metal_resist PF13801.4 001190277.1_49829001_1 - 0.11 12.5 0.5 1.6 8.8 0.1 2.3 2 0 0 2 2 2 0 Heavy-metal resistance Ion_trans PF00520.29 214177.1_49825001_1 - 4.3e-31 107.9 11.6 6.8e-31 107.2 11.6 1.3 1 0 0 1 1 1 1 Ion transport protein CLZ PF16526.3 214177.1_49825001_1 - 2.3e-30 104.6 3.8 2.3e-30 104.6 3.8 2.4 2 0 0 2 2 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels cNMP_binding PF00027.27 214177.1_49825001_1 - 1.4e-17 63.4 0.0 2.3e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain DDHD PF02862.15 214177.1_49825001_1 - 0.00081 19.5 3.3 0.0015 18.6 3.3 1.4 1 0 0 1 1 1 1 DDHD domain Connexin PF00029.17 214177.1_49825001_1 - 0.007 16.0 1.5 0.013 15.1 1.5 1.4 1 0 0 1 1 1 1 Connexin Ion_trans_2 PF07885.14 214177.1_49825001_1 - 0.0088 15.9 2.9 0.03 14.2 2.9 2.0 1 0 0 1 1 1 1 Ion channel Zip PF02535.20 214177.1_49825001_1 - 0.0098 15.0 1.7 0.017 14.2 1.7 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter Tim54 PF11711.6 214177.1_49825001_1 - 0.019 13.6 11.1 0.035 12.8 11.1 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Presenilin PF01080.15 214177.1_49825001_1 - 0.027 13.1 7.2 0.045 12.4 7.2 1.4 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.11 214177.1_49825001_1 - 0.029 13.0 9.9 0.044 12.5 9.9 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF913 PF06025.10 214177.1_49825001_1 - 0.03 13.2 2.0 0.049 12.4 2.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4746 PF15928.3 214177.1_49825001_1 - 0.059 12.6 10.9 0.1 11.9 10.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SLC12 PF03522.13 214177.1_49825001_1 - 0.06 12.2 7.0 0.097 11.5 7.0 1.3 1 0 0 1 1 1 0 Solute carrier family 12 RNA_polI_A34 PF08208.9 214177.1_49825001_1 - 0.076 13.0 32.1 0.14 12.1 32.1 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Eapp_C PF10238.7 214177.1_49825001_1 - 0.13 12.2 8.6 0.38 10.7 8.6 1.7 1 0 0 1 1 1 0 E2F-associated phosphoprotein RR_TM4-6 PF06459.10 214177.1_49825001_1 - 0.17 11.5 20.6 0.28 10.9 20.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FGF-BP1 PF06473.10 214177.1_49825001_1 - 0.2 11.4 14.4 0.35 10.6 14.4 1.3 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) Sec62 PF03839.14 214177.1_49825001_1 - 0.23 10.8 18.9 0.044 13.2 14.5 1.9 2 0 0 2 2 2 0 Translocation protein Sec62 MCU PF04678.11 214177.1_49825001_1 - 0.29 11.1 7.5 2.6 8.0 0.5 3.0 3 1 0 3 3 2 0 Mitochondrial calcium uniporter CLN3 PF02487.15 214177.1_49825001_1 - 0.55 9.1 2.7 1 8.2 2.7 1.4 1 0 0 1 1 1 0 CLN3 protein MIP-T3 PF10243.7 214177.1_49825001_1 - 0.59 8.7 27.2 0.94 8.0 27.2 1.3 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF106 PF01956.14 214177.1_49825001_1 - 0.64 9.6 13.3 0.13 11.9 1.7 3.2 4 1 0 4 4 2 0 Integral membrane protein DUF106 FancD2 PF14631.4 214177.1_49825001_1 - 0.69 7.1 8.7 1.1 6.4 8.7 1.2 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease MCM_bind PF09739.7 214177.1_49825001_1 - 0.76 8.0 8.8 1.2 7.3 8.8 1.3 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor FAM76 PF16046.3 214177.1_49825001_1 - 1.2 8.3 18.6 2.8 7.1 12.7 2.3 2 0 0 2 2 2 0 FAM76 protein ALMT PF11744.6 214177.1_49825001_1 - 1.5 7.5 7.2 2.5 6.7 7.2 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Serinc PF03348.13 214177.1_49825001_1 - 2.6 6.8 7.3 0.099 11.4 1.3 1.6 2 0 0 2 2 2 0 Serine incorporator (Serinc) SpoIIP PF07454.9 214177.1_49825001_1 - 3.3 6.9 21.5 7.8 5.7 21.5 1.6 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) GAGA_bind PF06217.10 214177.1_49825001_1 - 3.5 7.7 12.9 6.3 6.9 12.9 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family CCSAP PF15748.3 214177.1_49825001_1 - 3.9 7.5 22.1 6.5 6.8 22.1 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Afi1 PF07792.10 214177.1_49825001_1 - 5.6 7.3 18.5 1.3 9.4 14.8 1.8 2 0 0 2 2 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Rtf2 PF04641.10 214177.1_49825001_1 - 6.2 6.0 22.1 14 4.8 22.1 1.5 1 0 0 1 1 1 0 Rtf2 RING-finger Neur_chan_memb PF02932.14 214177.1_49825001_1 - 6.2 6.7 8.1 2 8.3 4.6 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region AAA_11 PF13086.4 214177.1_49825001_1 - 6.6 6.2 12.0 14 5.1 12.0 1.5 1 0 0 1 1 1 0 AAA domain S_100 PF01023.17 001252605.1_49821001_1 - 6.8e-20 70.4 0.5 6.8e-20 70.4 0.5 1.8 2 0 0 2 2 2 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 001252605.1_49821001_1 - 1.5e-06 28.4 0.3 2.2e-06 27.9 0.3 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 001252605.1_49821001_1 - 4.8e-05 22.5 0.5 0.0016 17.7 0.1 2.4 2 0 0 2 2 2 1 EF hand EF-hand_4 PF12763.5 001252605.1_49821001_1 - 0.00077 19.2 0.0 0.00098 18.9 0.0 1.2 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_8 PF13833.4 001252605.1_49821001_1 - 0.0019 17.8 0.3 0.0052 16.4 0.1 1.9 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.4 001252605.1_49821001_1 - 0.0026 17.4 0.5 0.63 10.0 0.0 2.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.4 001252605.1_49821001_1 - 0.014 14.7 0.7 0.23 10.9 0.0 2.4 2 0 0 2 2 2 0 EF hand Smac_DIABLO PF09057.8 001190216.1_49823001_3 - 2.4e-102 340.9 9.7 3.2e-102 340.5 9.7 1.1 1 0 0 1 1 1 1 Second Mitochondria-derived Activator of Caspases Trs65 PF12735.5 001190216.1_49823001_3 - 0.15 11.3 1.2 0.21 10.8 1.2 1.1 1 0 0 1 1 1 0 TRAPP trafficking subunit Trs65 D123 PF07065.12 001243823.1_49824001_2 - 2.8e-105 351.7 0.2 3.3e-105 351.5 0.2 1.0 1 0 0 1 1 1 1 D123 DUF4343 PF14243.4 001243823.1_49824001_2 - 0.0013 18.9 0.0 0.0022 18.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4343) Reg_prop PF07494.9 001243823.1_49824001_2 - 0.15 12.2 0.1 0.51 10.6 0.1 1.9 1 0 0 1 1 1 0 Two component regulator propeller C1q PF00386.19 001112679.1_49822001_1 - 1.2e-26 93.3 0.1 1.5e-26 93.0 0.1 1.1 1 0 0 1 1 1 1 C1q domain MFS_1 PF07690.14 001243400.1_49825001_3 - 9.3e-32 110.2 40.6 4.8e-31 107.8 39.5 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily p450 PF00067.20 001315792.1_49824001_3 - 1.1e-62 212.2 0.0 1.5e-62 211.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Fascin PF06268.11 001146300.2_49826001_1 - 3e-123 404.0 0.3 9.3e-35 119.1 0.0 4.1 4 0 0 4 4 4 4 Fascin domain FRG1 PF06229.10 001146300.2_49826001_1 - 4.9e-17 62.1 0.1 0.0096 15.5 0.1 5.9 3 3 4 7 7 7 6 FRG1-like domain FGF PF00167.16 001146300.2_49826001_1 - 0.058 13.4 0.0 3.6 7.6 0.0 2.8 2 1 1 3 3 3 0 Fibroblast growth factor DUF569 PF04601.11 001146300.2_49826001_1 - 0.081 12.5 0.0 1.2 8.7 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF569) zf-C2H2 PF00096.24 001164009.1_49826001_1 - 1.2e-13 50.6 22.1 2.7e-05 24.3 3.7 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001164009.1_49826001_1 - 8.3e-12 44.9 27.6 5.4e-07 29.6 3.6 4.4 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 001164009.1_49826001_1 - 1.6e-06 28.3 19.5 0.00089 19.8 2.2 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger FOXP-CC PF16159.3 001164009.1_49826001_1 - 0.00044 20.7 8.1 0.012 16.1 0.4 3.1 3 0 0 3 3 3 2 FOXP coiled-coil domain zf-C2H2_6 PF13912.4 001164009.1_49826001_1 - 0.014 15.2 0.7 0.014 15.2 0.7 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_8 PF15909.3 001164009.1_49826001_1 - 0.14 12.3 5.8 0.27 11.4 5.8 1.3 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-Di19 PF05605.10 001164009.1_49826001_1 - 0.52 10.5 10.0 0.36 11.0 2.5 2.5 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.4 001164009.1_49826001_1 - 7.4 6.5 8.7 3.9 7.4 2.5 2.7 2 0 0 2 2 2 0 zinc-finger of a C2HC-type RRM_1 PF00076.20 001195598.1_49822001_3 - 1.9e-19 69.1 0.0 3e-19 68.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 001195598.1_49822001_3 - 6.3e-05 22.7 0.0 0.00011 21.9 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif 7tm_1 PF00001.19 001315774.1_49823001_1 - 4.8e-51 173.4 23.3 4.8e-51 173.4 23.3 1.4 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001315774.1_49823001_1 - 5.4e-15 55.3 22.1 6.8e-15 55.0 22.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001315774.1_49823001_1 - 2.8e-06 27.2 11.0 2.8e-06 27.2 11.0 1.6 1 1 0 1 1 1 1 Olfactory receptor Trypsin PF00089.24 213802.1_49823001_3 - 8.4e-68 228.3 0.2 1e-67 228.1 0.2 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 213802.1_49823001_3 - 0.00012 22.9 0.0 0.00018 22.2 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 213802.1_49823001_3 - 0.00022 21.5 0.1 0.00065 19.9 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1986) OATP PF03137.18 001123195.2_49824001_1 - 4e-177 589.7 12.9 4.8e-177 589.4 12.9 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 001123195.2_49824001_1 - 2.1e-21 76.1 35.8 5.3e-21 74.8 28.2 3.0 2 1 0 2 2 2 2 Major Facilitator Superfamily Kazal_2 PF07648.13 001123195.2_49824001_1 - 4.1e-07 29.9 4.2 8.4e-07 29.0 4.2 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 001123195.2_49824001_1 - 0.0039 17.0 3.4 0.0098 15.8 3.4 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Adhes-Ig_like PF09085.8 001037998.2_49823001_2 - 1.1e-55 186.3 0.4 1.8e-55 185.7 0.4 1.3 1 0 0 1 1 1 1 Adhesion molecule, immunoglobulin-like Ig_3 PF13927.4 001037998.2_49823001_2 - 0.0024 18.3 0.8 0.34 11.4 0.0 3.2 3 0 0 3 3 3 1 Immunoglobulin domain ICAM_N PF03921.12 001037998.2_49823001_2 - 0.14 11.7 0.1 0.41 10.2 0.0 1.8 2 0 0 2 2 2 0 Intercellular adhesion molecule (ICAM), N-terminal domain LLC1 PF14945.4 001123088.1_49822001_2 - 1.6e-49 167.3 0.2 2.2e-49 166.9 0.2 1.2 1 0 0 1 1 1 1 Normal lung function maintenance, Low in Lung Cancer 1 protein TF_AP-2 PF03299.12 001244520.1_49823001_3 - 9e-88 293.2 0.0 1.3e-87 292.7 0.0 1.2 1 0 0 1 1 1 1 Transcription factor AP-2 adh_short PF00106.23 001244732.1_49823001_2 - 6.7e-34 116.9 0.0 2.8e-26 92.1 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.4 001244732.1_49823001_2 - 4.4e-27 95.0 0.0 2.5e-19 69.7 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001244732.1_49823001_2 - 7.2e-09 35.7 0.0 1.2e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.16 001244732.1_49823001_2 - 0.026 14.6 0.1 0.12 12.5 0.0 1.9 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain V-set PF07686.15 001244799.1_49825001_2 - 4.6e-15 55.6 0.1 3.6e-14 52.7 0.0 2.6 3 0 0 3 3 3 1 Immunoglobulin V-set domain SPRY PF00622.26 001244799.1_49825001_2 - 7.7e-15 55.0 0.0 1.4e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 SPRY domain PRY PF13765.4 001244799.1_49825001_2 - 5.9e-07 28.9 3.8 9.1e-07 28.3 0.0 2.9 3 0 0 3 3 3 1 SPRY-associated domain Ig_3 PF13927.4 001244799.1_49825001_2 - 3.2e-06 27.5 0.0 0.0042 17.5 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001244799.1_49825001_2 - 0.00015 21.6 0.1 0.25 11.3 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin I-set domain Myotoxins PF00819.15 001244799.1_49825001_2 - 0.00024 21.2 0.2 0.00094 19.3 0.2 2.0 1 0 0 1 1 1 1 Myotoxin, crotamine DUF2681 PF10883.6 001244799.1_49825001_2 - 0.0034 17.6 2.5 0.0063 16.8 2.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2681) DUF2140 PF09911.7 001244799.1_49825001_2 - 0.0078 15.6 0.9 0.012 15.0 0.3 1.6 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2140) ig PF00047.23 001244799.1_49825001_2 - 0.012 15.6 0.0 2.8 8.0 0.0 3.0 2 1 0 2 2 2 0 Immunoglobulin domain FixQ PF05545.9 001244799.1_49825001_2 - 0.021 14.6 0.1 0.046 13.6 0.1 1.5 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ ATP-synt_E PF05680.10 001244799.1_49825001_2 - 0.036 14.3 1.7 0.069 13.4 1.7 1.4 1 0 0 1 1 1 0 ATP synthase E chain MFS_Mycoplasma PF07672.11 001244799.1_49825001_2 - 0.093 11.9 0.1 0.14 11.3 0.1 1.2 1 0 0 1 1 1 0 Mycoplasma MFS transporter NACHT PF05729.10 001256770.2_49828001_3 - 3.4e-46 157.1 0.0 7.4e-46 156.0 0.0 1.6 1 0 0 1 1 1 1 NACHT domain PYRIN PF02758.14 001256770.2_49828001_3 - 2.3e-21 75.6 0.1 8.9e-21 73.8 0.1 2.1 1 0 0 1 1 1 1 PAAD/DAPIN/Pyrin domain LRR_6 PF13516.4 001256770.2_49828001_3 - 1.3e-17 62.2 37.0 0.00041 20.1 0.4 7.6 8 0 0 8 8 8 5 Leucine Rich repeat FISNA PF14484.4 001256770.2_49828001_3 - 1.9e-15 56.7 0.1 4.1e-15 55.6 0.1 1.6 1 0 0 1 1 1 1 Fish-specific NACHT associated domain LRR_4 PF12799.5 001256770.2_49828001_3 - 6.6e-08 32.6 29.4 0.14 12.5 0.2 6.5 2 2 5 7 7 7 7 Leucine Rich repeats (2 copies) NB-ARC PF00931.20 001256770.2_49828001_3 - 0.019 13.9 0.0 0.037 12.9 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_16 PF13191.4 001256770.2_49828001_3 - 0.12 12.7 0.0 0.43 10.8 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain LRR_8 PF13855.4 001256770.2_49828001_3 - 4.1 7.1 26.7 8.8 6.0 0.4 6.1 4 1 1 5 5 5 0 Leucine rich repeat LRR_1 PF00560.31 001256770.2_49828001_3 - 4.1 8.1 36.8 6.7 7.5 0.1 9.1 8 1 0 8 8 8 0 Leucine Rich Repeat 7tm_2 PF00002.22 001144110.1_49823001_1 - 7.4e-79 264.4 19.3 1e-78 263.9 19.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 001144110.1_49823001_1 - 4.9e-17 61.8 1.4 1e-16 60.8 1.4 1.6 1 0 0 1 1 1 1 Hormone receptor domain Glyco_trans_1_2 PF13524.4 001144110.1_49823001_1 - 0.14 12.4 0.4 12 6.2 0.0 2.3 2 0 0 2 2 2 0 Glycosyl transferases group 1 NuA4 PF09340.8 001243456.1_49823001_2 - 3.9e-27 93.8 2.3 3.9e-27 93.8 2.3 1.9 2 0 0 2 2 2 1 Histone acetyltransferase subunit NuA4 DUF4201 PF13870.4 001244688.1_49823001_1 - 4.7e-43 146.7 27.2 4.7e-43 146.7 27.2 2.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4201) Dynein_attach_N PF15867.3 001244688.1_49823001_1 - 0.039 13.8 1.3 0.15 11.9 1.3 2.0 1 0 0 1 1 1 0 Dynein attachment factor N-terminus DUF4891 PF16232.3 001244688.1_49823001_1 - 0.28 11.6 5.0 0.92 9.9 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4891) KxDL PF10241.7 001244688.1_49823001_1 - 1.2 9.3 22.4 0.051 13.7 5.8 4.1 2 2 1 4 4 4 0 Uncharacterized conserved protein Sulfate_transp PF00916.18 001130248.1_49825001_1 - 4.1e-118 394.3 23.2 5.3e-118 394.0 23.2 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.19 001130248.1_49825001_1 - 1.6e-38 130.8 0.2 3.2e-38 129.8 0.2 1.5 1 0 0 1 1 1 1 STAS domain MHC_I PF00129.16 001113703.1_49823001_1 - 5.7e-83 276.7 3.5 7.5e-83 276.3 3.5 1.1 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001113703.1_49823001_1 - 2.7e-18 66.1 0.1 7.7e-18 64.6 0.1 1.8 2 0 0 2 2 2 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001113703.1_49823001_1 - 3.2e-08 33.2 1.9 6.2e-08 32.3 1.9 1.5 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 001113703.1_49823001_1 - 0.00021 21.7 1.2 0.0019 18.6 0.2 2.8 2 1 1 3 3 3 1 Immunoglobulin domain MHC_I_3 PF16497.3 001113703.1_49823001_1 - 0.00025 20.4 0.0 0.00039 19.8 0.0 1.3 1 0 0 1 1 1 1 MHC-I family domain ig PF00047.23 001113703.1_49823001_1 - 0.00043 20.3 0.1 0.0014 18.6 0.1 1.9 2 0 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.10 001113703.1_49823001_1 - 0.0091 15.9 0.1 0.022 14.7 0.1 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.4 001113703.1_49823001_1 - 0.014 15.6 0.1 0.04 14.1 0.1 1.8 1 0 0 1 1 1 0 Immunoglobulin domain MHC_I_2 PF14586.4 001113703.1_49823001_1 - 0.014 15.2 0.0 0.018 14.8 0.0 1.2 1 0 0 1 1 1 0 Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2 Tissue_fac PF01108.15 001111258.1_49824001_1 - 2.8e-19 68.8 0.0 6.5e-19 67.6 0.0 1.6 1 0 0 1 1 1 1 Tissue factor Interfer-bind PF09294.8 001111258.1_49824001_1 - 2e-08 34.4 0.0 4.3e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.19 001111258.1_49824001_1 - 1.5e-07 31.5 1.0 0.004 17.4 0.0 2.4 2 0 0 2 2 2 2 Fibronectin type III domain cEGF PF12662.5 001315577.1_49824001_1 - 7.7e-31 105.5 32.7 1.9e-09 37.1 2.1 5.9 5 0 0 5 5 5 5 Complement Clr-like EGF-like EGF_CA PF07645.13 001315577.1_49824001_1 - 7.4e-28 96.4 57.7 2.3e-10 40.4 7.1 5.9 4 1 1 5 5 5 5 Calcium-binding EGF domain FXa_inhibition PF14670.4 001315577.1_49824001_1 - 3.7e-23 81.4 69.3 1.6e-07 31.3 8.9 5.7 5 0 0 5 5 5 5 Coagulation Factor Xa inhibitory site EGF PF00008.25 001315577.1_49824001_1 - 8.5e-12 45.0 65.1 4.5e-06 26.7 7.2 6.1 5 0 0 5 5 5 5 EGF-like domain Lectin_C PF00059.19 001315577.1_49824001_1 - 2.6e-09 37.7 0.0 6e-09 36.5 0.0 1.7 1 0 0 1 1 1 1 Lectin C-type domain EGF_3 PF12947.5 001315577.1_49824001_1 - 1.6e-05 24.9 51.1 0.092 12.8 7.4 6.0 5 0 0 5 5 5 4 EGF domain TMEM154 PF15102.4 001315577.1_49824001_1 - 0.0012 18.7 0.0 0.0021 17.8 0.0 1.4 1 0 0 1 1 1 1 TMEM154 protein family hEGF PF12661.5 001315577.1_49824001_1 - 0.0027 18.2 5.1 0.0027 18.2 5.1 7.6 9 0 0 9 9 5 3 Human growth factor-like EGF stn_TNFRSF12A PF12191.6 001315577.1_49824001_1 - 0.023 14.8 0.1 0.13 12.4 0.0 2.2 2 0 0 2 2 2 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain TMEM51 PF15345.4 001315577.1_49824001_1 - 0.028 14.1 0.0 0.049 13.3 0.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 TRAP_alpha PF03896.14 001315577.1_49824001_1 - 0.24 10.5 0.0 0.37 9.8 0.0 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit SIT PF15330.4 001315577.1_49824001_1 - 0.27 11.5 0.0 0.27 11.5 0.0 1.7 2 0 0 2 2 1 0 SHP2-interacting transmembrane adaptor protein, SIT CcmD PF04995.12 001315577.1_49824001_1 - 5.3 7.1 6.4 0.26 11.3 0.4 1.8 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) Gtr1_RagA PF04670.10 001243623.1_49824001_2 - 5.2e-72 241.8 1.2 6.8e-72 241.4 1.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.19 001243623.1_49824001_2 - 4.2e-07 29.5 0.0 6.3e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001243623.1_49824001_2 - 2e-05 24.0 0.0 3.4e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.11 001243623.1_49824001_2 - 4.4e-05 23.6 0.0 7.6e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001243623.1_49824001_2 - 0.0041 16.6 0.0 0.0061 16.0 0.0 1.2 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.21 001243623.1_49824001_2 - 0.022 14.7 0.0 0.051 13.5 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.4 001243623.1_49824001_2 - 0.093 13.0 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Syja_N PF02383.16 001243250.1_49827001_2 - 5.8e-72 242.5 0.0 9.9e-72 241.7 0.0 1.4 1 0 0 1 1 1 1 SacI homology domain Mito_carr PF00153.25 214418.2_49823001_3 - 3.2e-67 222.4 4.8 2.7e-25 88.0 0.1 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein FKBP_C PF00254.26 001195337.2_49824001_2 - 4.5e-49 164.6 0.0 1.4e-31 108.5 0.0 2.4 2 0 0 2 2 2 2 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.26 001195337.2_49824001_2 - 6.9e-21 73.0 5.9 7.2e-08 31.8 0.5 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.15 001195337.2_49824001_2 - 9.5e-17 59.6 3.8 8.8e-06 25.3 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.4 001195337.2_49824001_2 - 5.5e-12 44.8 3.5 0.00014 21.6 0.4 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.4 001195337.2_49824001_2 - 1.5e-09 37.9 1.0 4.1e-05 23.7 0.9 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.4 001195337.2_49824001_2 - 5.1e-09 35.5 4.3 0.00056 19.4 0.0 3.4 2 1 1 3 3 3 2 TPR repeat TPR_6 PF13174.4 001195337.2_49824001_2 - 1.7e-07 31.3 6.4 0.0029 18.0 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.4 001195337.2_49824001_2 - 7.5e-06 26.4 2.7 0.27 11.9 0.7 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.4 001195337.2_49824001_2 - 2e-05 24.9 0.6 0.015 15.9 0.5 3.5 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.4 001195337.2_49824001_2 - 5.2e-05 23.6 8.7 0.034 14.5 1.3 2.8 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.4 001195337.2_49824001_2 - 8.2e-05 22.6 0.1 0.0022 18.0 0.2 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.4 001195337.2_49824001_2 - 0.0024 17.6 3.0 1.3 9.1 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat OmpH PF03938.12 001195337.2_49824001_2 - 0.0035 17.2 7.5 0.0077 16.1 7.5 1.6 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) PknG_TPR PF16918.3 001195337.2_49824001_2 - 0.0063 15.2 0.3 0.0092 14.6 0.3 1.3 1 0 0 1 1 1 1 Protein kinase G tetratricopeptide repeat TPR_17 PF13431.4 001195337.2_49824001_2 - 0.0097 16.1 6.1 0.2 12.0 0.2 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.4 001195337.2_49824001_2 - 0.14 12.0 1.5 18 5.2 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat YfiO PF13525.4 001195337.2_49824001_2 - 0.17 11.5 5.0 0.14 11.7 0.6 2.3 2 1 0 2 2 2 0 Outer membrane lipoprotein ANAPC3 PF12895.5 001195337.2_49824001_2 - 0.57 10.3 9.1 3.9 7.6 1.1 3.0 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.4 001195337.2_49824001_2 - 2.5 8.1 7.7 6.6 6.7 0.1 2.9 2 1 1 3 3 2 0 Fis1 C-terminal tetratricopeptide repeat CHORD PF04968.10 001113446.1_49822001_1 - 9.1e-56 186.3 20.4 3.8e-29 101.0 2.6 3.0 3 0 0 3 3 3 2 CHORD CS PF04969.14 001113446.1_49822001_1 - 1.3e-14 54.8 0.3 2.5e-14 53.9 0.3 1.5 1 0 0 1 1 1 1 CS domain p450 PF00067.20 001315809.1_49827001_1 - 3e-46 158.0 0.2 4.2e-46 157.5 0.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 DNA_methylase PF00145.15 001097437.1_49826001_2 - 2.5e-16 59.8 0.0 7.1e-12 45.2 0.0 2.5 2 0 0 2 2 2 2 C-5 cytosine-specific DNA methylase PWWP PF00855.15 001097437.1_49826001_2 - 3e-12 46.7 1.3 7.4e-12 45.4 0.4 2.2 2 0 0 2 2 2 1 PWWP domain GCV_T PF01571.19 001244426.1_49825001_3 - 2.4e-84 282.6 0.0 3e-84 282.3 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.9 001244426.1_49825001_3 - 3.9e-22 78.2 0.1 7.3e-22 77.3 0.1 1.5 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain RNHCP PF12647.5 001243377.1_49822001_1 - 0.14 12.0 3.0 0.24 11.3 3.0 1.3 1 0 0 1 1 1 0 RNHCP domain LIN37 PF15306.4 001243377.1_49822001_3 - 1.4e-48 164.9 1.1 2.8e-48 164.0 1.1 1.5 1 0 0 1 1 1 1 LIN37 IRS PF02174.15 001123107.1_49822001_1 - 1.2e-29 102.0 0.0 2.1e-29 101.2 0.0 1.4 1 0 0 1 1 1 1 PTB domain (IRS-1 type) PH PF00169.27 001123107.1_49822001_1 - 0.00043 20.6 0.3 0.00074 19.9 0.3 1.4 1 0 0 1 1 1 1 PH domain PIG-S PF10510.7 001244339.1_49826001_3 - 1.5e-141 472.7 0.2 1.8e-141 472.4 0.2 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein p450 PF00067.20 001244636.1_49825001_2 - 5.2e-132 440.7 0.0 6.4e-132 440.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CEBP1_N PF16368.3 001097510.1_49824001_1 - 1.8e-155 516.9 11.3 2.8e-155 516.3 11.3 1.3 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein 1 N-terminus RRM_7 PF16367.3 001097510.1_49824001_1 - 2.9e-35 120.1 0.0 9.1e-35 118.5 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif CEBP_ZZ PF16366.3 001097510.1_49824001_1 - 6.3e-24 83.8 6.9 6.3e-24 83.8 6.9 1.8 2 0 0 2 2 2 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.20 001097510.1_49824001_1 - 2.4e-08 33.5 0.0 0.0025 17.5 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-P11 PF03854.12 001097510.1_49824001_1 - 0.47 10.0 6.3 2.7 7.6 0.0 2.8 3 0 0 3 3 3 0 P-11 zinc finger Sulfate_transp PF00916.18 001012298.2_49825001_1 - 6.1e-108 360.8 19.4 7.9e-108 360.5 19.4 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.19 001012298.2_49825001_1 - 6.3e-21 74.1 0.0 1.3e-20 73.1 0.0 1.5 1 1 0 1 1 1 1 STAS domain Sp38 PF07354.10 001164513.1_49823001_3 - 1e-90 303.2 9.3 1.8e-57 194.1 6.4 2.1 1 1 1 2 2 2 2 Zona-pellucida-binding protein (Sp38) NCD3G PF07562.12 001164513.1_49823001_3 - 0.032 14.1 5.2 0.064 13.1 5.2 1.5 1 0 0 1 1 1 0 Nine Cysteines Domain of family 3 GPCR GRAM PF02893.18 001244333.1_49824001_1 - 3.3e-18 65.4 0.2 5.7e-18 64.7 0.2 1.3 1 0 0 1 1 1 1 GRAM domain 7TM_GPCR_Srd PF10317.7 001244333.1_49824001_1 - 0.15 11.1 2.2 0.088 11.9 0.2 1.5 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srd NIF PF03031.16 001244547.1_49824001_1 - 3.9e-52 176.0 0.0 5.3e-52 175.6 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Thionin PF00321.15 001244547.1_49824001_3 - 1.8 9.0 8.0 9.8 6.7 0.3 2.5 2 0 0 2 2 2 0 Plant thionin SCAN PF02023.15 001245009.1_49824001_2 - 1.2e-40 137.1 3.2 2.1e-40 136.3 3.2 1.4 1 0 0 1 1 1 1 SCAN domain zf-H2C2_2 PF13465.4 001245009.1_49824001_2 - 1.2e-36 123.3 28.2 2.6e-08 33.8 0.2 6.6 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.24 001245009.1_49824001_2 - 2.3e-28 96.9 26.6 1.8e-07 31.1 0.9 5.5 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001245009.1_49824001_2 - 1.3e-12 47.3 27.6 0.0031 18.1 0.5 5.8 5 0 0 5 5 5 5 C2H2-type zinc finger XPA_N PF01286.16 001245009.1_49824001_2 - 7.7e-06 25.7 15.4 0.23 11.4 0.4 5.2 5 0 0 5 5 5 2 XPA protein N-terminal zf-C2H2_6 PF13912.4 001245009.1_49824001_2 - 3e-05 23.7 18.8 0.39 10.6 0.2 5.4 5 0 0 5 5 5 3 C2H2-type zinc finger zf-trcl PF13451.4 001245009.1_49824001_2 - 4.8e-05 23.0 10.6 1.1 9.0 0.0 5.2 5 0 0 5 5 5 1 Probable zinc-ribbon domain Zn-ribbon_8 PF09723.8 001245009.1_49824001_2 - 8.1e-05 22.5 16.7 0.0026 17.7 2.7 3.7 2 1 1 3 3 3 2 Zinc ribbon domain zf-C2H2_11 PF16622.3 001245009.1_49824001_2 - 0.0045 16.6 18.0 0.17 11.5 0.3 5.3 5 0 0 5 5 5 1 zinc-finger C2H2-type DUF2321 PF10083.7 001245009.1_49824001_2 - 0.014 14.9 7.0 0.14 11.7 0.2 2.9 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) zinc_ribbon_15 PF17032.3 001245009.1_49824001_2 - 0.014 16.0 10.4 0.93 10.2 3.8 2.7 1 1 1 2 2 2 0 zinc-ribbon family HypA PF01155.17 001245009.1_49824001_2 - 0.067 13.1 9.6 4.5 7.2 2.9 3.0 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-LYAR PF08790.9 001245009.1_49824001_2 - 0.11 12.3 12.4 0.59 10.0 0.4 4.4 5 0 0 5 5 4 0 LYAR-type C2HC zinc finger YhfH PF14149.4 001245009.1_49824001_2 - 0.12 12.2 13.8 16 5.4 0.1 5.2 5 0 0 5 5 5 0 YhfH-like protein DZR PF12773.5 001245009.1_49824001_2 - 0.2 11.6 12.8 4e+02 1.0 12.8 3.1 1 1 0 1 1 1 0 Double zinc ribbon zf-C2H2_jaz PF12171.6 001245009.1_49824001_2 - 0.29 11.4 15.2 2.9 8.2 0.2 4.7 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 001245009.1_49824001_2 - 0.37 10.5 20.6 4.2 7.1 1.1 5.2 4 2 0 4 4 4 0 C2H2-type zinc-finger domain zf-AN1 PF01428.14 001245009.1_49824001_2 - 0.54 10.3 16.5 17 5.6 0.1 4.9 5 0 0 5 5 5 0 AN1-like Zinc finger DUF3268 PF11672.6 001245009.1_49824001_2 - 0.96 9.7 9.3 2 8.7 0.7 3.0 1 1 3 4 4 4 0 zinc-finger-containing domain C1_4 PF07975.10 001245009.1_49824001_2 - 1 9.5 12.4 1.7 8.8 1.6 3.5 2 1 2 4 4 4 0 TFIIH C1-like domain CpXC PF14353.4 001245009.1_49824001_2 - 1.4 8.9 9.9 61 3.5 0.6 4.8 1 1 2 4 4 4 0 CpXC protein GATA PF00320.25 001245009.1_49824001_2 - 2.3 7.8 9.2 36 4.0 0.1 4.2 4 1 0 4 4 4 0 GATA zinc finger zf-BED PF02892.13 001245009.1_49824001_2 - 3 7.8 18.8 0.7 9.9 2.3 4.6 1 1 3 4 4 4 0 BED zinc finger FYVE PF01363.19 001245009.1_49824001_2 - 3.7 7.6 15.6 4.4e+03 -2.2 15.5 3.4 1 1 0 1 1 1 0 FYVE zinc finger zinc_ribbon_4 PF13717.4 001245009.1_49824001_2 - 9.2 6.2 12.4 43 4.0 0.1 4.6 4 1 0 4 4 4 0 zinc-ribbon domain WD40 PF00400.30 001244931.1_49825001_3 - 5.2e-37 125.1 20.5 9.7e-07 29.3 0.4 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001244931.1_49825001_3 - 2.1e-05 24.6 2.6 0.4 10.9 0.1 4.9 3 2 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.4 001244931.1_49825001_3 - 0.0029 17.5 0.0 9.4 6.2 0.0 4.2 3 1 2 5 5 5 1 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.6 001244931.1_49825001_3 - 0.0057 15.2 3.4 0.55 8.7 0.4 3.7 1 1 3 4 4 4 1 Nucleoporin Nup120/160 zf-C2H2 PF00096.24 001134346.2_49828001_3 - 9.5e-13 47.7 21.1 0.00027 21.1 2.6 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001134346.2_49828001_3 - 2.8e-11 43.2 9.2 1.2e-06 28.6 1.8 3.9 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 001134346.2_49828001_3 - 2e-07 31.1 18.3 0.0058 17.2 1.4 4.0 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_8 PF15909.3 001134346.2_49828001_3 - 0.0056 16.8 5.8 0.016 15.3 5.8 1.8 1 0 0 1 1 1 1 C2H2-type zinc ribbon FOXP-CC PF16159.3 001134346.2_49828001_3 - 0.0065 16.9 5.6 4.2 7.9 0.3 3.4 1 1 2 3 3 3 2 FOXP coiled-coil domain zf-C2H2_6 PF13912.4 001134346.2_49828001_3 - 1.1 9.1 13.0 0.08 12.8 0.9 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger zf-Di19 PF05605.10 001134346.2_49828001_3 - 8.9 6.6 11.4 0.15 12.2 1.3 2.8 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Lectin_C PF00059.19 001129957.1_49823001_1 - 1.9e-24 86.3 2.6 3.7e-24 85.4 2.6 1.5 1 0 0 1 1 1 1 Lectin C-type domain Phage_GP20 PF06810.9 001129957.1_49823001_1 - 0.00013 21.7 0.6 0.0002 21.1 0.6 1.3 1 0 0 1 1 1 1 Phage minor structural protein GP20 TMF_TATA_bd PF12325.6 001129957.1_49823001_1 - 0.00024 21.2 1.0 0.00051 20.1 1.0 1.6 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding MAD PF05557.11 001129957.1_49823001_1 - 0.00025 19.4 0.8 0.00033 19.0 0.8 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein T3SSipB PF16535.3 001129957.1_49823001_1 - 0.0003 21.2 1.8 0.00046 20.6 1.8 1.2 1 0 0 1 1 1 1 Type III cell invasion protein SipB HAUS5 PF14817.4 001129957.1_49823001_1 - 0.00079 18.0 1.1 0.0011 17.6 1.1 1.2 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 5 TPR_MLP1_2 PF07926.10 001129957.1_49823001_1 - 0.0014 18.6 0.7 0.0014 18.6 0.7 1.8 2 0 0 2 2 1 1 TPR/MLP1/MLP2-like protein HOOK PF05622.10 001129957.1_49823001_1 - 0.0019 16.3 0.0 0.0024 16.0 0.0 1.1 1 0 0 1 1 1 1 HOOK protein DUF812 PF05667.9 001129957.1_49823001_1 - 0.0039 16.0 0.1 0.005 15.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) NPV_P10 PF05531.10 001129957.1_49823001_1 - 0.0044 17.3 4.1 0.4 11.0 4.1 2.7 1 1 0 1 1 1 1 Nucleopolyhedrovirus P10 protein Spc42p PF11544.6 001129957.1_49823001_1 - 0.0085 15.9 0.8 0.043 13.7 0.2 2.3 2 1 1 3 3 3 1 Spindle pole body component Spc42p RPW8 PF05659.9 001129957.1_49823001_1 - 0.0088 15.6 0.5 0.018 14.6 0.3 1.6 1 1 0 1 1 1 1 Arabidopsis broad-spectrum mildew resistance protein RPW8 TBPIP PF07106.11 001129957.1_49823001_1 - 0.011 15.4 1.7 0.031 13.9 1.1 1.7 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF484 PF04340.10 001129957.1_49823001_1 - 0.012 15.2 0.2 0.017 14.7 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF484 ABC_tran_CTD PF16326.3 001129957.1_49823001_1 - 0.013 15.6 0.4 0.03 14.4 0.4 1.6 1 0 0 1 1 1 0 ABC transporter C-terminal domain Reo_sigmaC PF04582.10 001129957.1_49823001_1 - 0.014 14.7 3.6 0.029 13.7 3.6 1.5 1 1 0 1 1 1 0 Reovirus sigma C capsid protein BLOC1_2 PF10046.7 001129957.1_49823001_1 - 0.025 14.7 1.0 0.26 11.5 0.1 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AAA_13 PF13166.4 001129957.1_49823001_1 - 0.047 12.2 0.1 0.061 11.9 0.1 1.1 1 0 0 1 1 1 0 AAA domain HMMR_N PF15905.3 001129957.1_49823001_1 - 0.05 12.9 0.7 0.072 12.4 0.7 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal CENP-F_leu_zip PF10473.7 001129957.1_49823001_1 - 0.051 13.5 1.9 0.17 11.8 0.9 1.9 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DASH_Dad4 PF08650.8 001129957.1_49823001_1 - 0.057 13.3 1.0 7 6.6 0.0 3.0 1 1 2 3 3 3 0 DASH complex subunit Dad4 Tropomyosin PF00261.18 001129957.1_49823001_1 - 0.067 12.4 0.3 0.12 11.5 0.3 1.4 1 0 0 1 1 1 0 Tropomyosin DUF2203 PF09969.7 001129957.1_49823001_1 - 0.077 13.6 0.7 4.9 7.8 0.2 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Exonuc_VII_L PF02601.13 001129957.1_49823001_1 - 0.084 12.3 0.2 0.11 11.9 0.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Snapin_Pallidin PF14712.4 001129957.1_49823001_1 - 0.12 12.7 4.8 0.35 11.2 3.0 2.4 2 0 0 2 2 2 0 Snapin/Pallidin Phage_lysozyme PF00959.17 001129957.1_49823001_1 - 0.12 12.7 0.3 0.29 11.5 0.3 1.6 1 1 0 1 1 1 0 Phage lysozyme DUF16 PF01519.14 001129957.1_49823001_1 - 0.14 12.5 2.9 1.8 9.0 1.4 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF16 Seryl_tRNA_N PF02403.20 001129957.1_49823001_1 - 0.19 11.8 2.8 10 6.3 1.8 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4164 PF13747.4 001129957.1_49823001_1 - 0.21 11.7 1.5 0.42 10.8 1.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) DASH_Duo1 PF08651.8 001129957.1_49823001_1 - 0.27 10.9 5.1 8 6.2 0.3 3.3 3 1 1 4 4 3 0 DASH complex subunit Duo1 V-SNARE PF05008.13 001129957.1_49823001_1 - 0.28 11.4 1.3 0.78 10.0 0.7 2.0 1 1 1 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Fib_alpha PF08702.8 001129957.1_49823001_1 - 0.65 10.0 3.3 1.5 8.8 1.9 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.10 001129957.1_49823001_1 - 0.71 9.7 3.6 4.2 7.2 0.6 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DUF5082 PF16888.3 001129957.1_49823001_1 - 0.74 10.0 4.5 6 7.1 0.2 3.2 1 1 1 3 3 3 0 Domain of unknown function (DUF5082) DUF948 PF06103.9 001129957.1_49823001_1 - 1.9 8.6 3.9 21 5.3 1.1 2.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) FlaC_arch PF05377.9 001129957.1_49823001_1 - 2 8.8 4.7 11 6.3 0.8 3.5 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) GRAM PF02893.18 001243583.1_49824001_2 - 7.9e-20 70.7 0.0 1.4e-19 69.9 0.0 1.4 1 0 0 1 1 1 1 GRAM domain HAUS4 PF14735.4 001244156.1_49823001_3 - 6.7e-74 248.4 23.9 6.7e-74 248.4 23.9 1.3 1 1 0 1 1 1 1 HAUS augmin-like complex subunit 4 HCMV_UL139 PF12507.6 001244156.1_49823001_3 - 0.012 15.9 3.7 0.023 14.9 3.7 1.6 1 0 0 1 1 1 0 Human Cytomegalovirus UL139 protein CWC25 PF12542.6 001244652.1_49824001_3 - 2.9e-20 72.7 0.0 2.9e-20 72.7 0.0 3.2 4 0 0 4 4 4 1 Pre-mRNA splicing factor Cir_N PF10197.7 001244652.1_49824001_3 - 2.7e-15 56.1 13.4 2.7e-15 56.1 13.4 5.1 6 0 0 6 6 6 1 N-terminal domain of CBF1 interacting co-repressor CIR Interferon PF00143.17 001164846.1_49822001_1 - 2.2e-40 138.3 1.4 2.6e-40 138.1 1.4 1.1 1 0 0 1 1 1 1 Interferon alpha/beta domain Tcf25 PF04910.12 001164846.1_49822001_1 - 0.037 13.0 0.0 0.05 12.6 0.0 1.1 1 0 0 1 1 1 0 Transcriptional repressor TCF25 V-set PF07686.15 001204379.1_49824001_2 - 8.9e-17 61.1 0.0 1.7e-16 60.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001204379.1_49824001_2 - 1.4e-05 25.5 0.0 3.4e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001204379.1_49824001_2 - 0.00081 19.6 0.0 0.0034 17.6 0.0 2.0 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001204379.1_49824001_2 - 0.0024 17.9 0.1 0.0087 16.1 0.1 1.9 1 1 0 1 1 1 1 Immunoglobulin domain Telethonin PF09470.8 001145754.2_49822001_1 - 8.4e-75 250.1 2.0 9.5e-75 249.9 2.0 1.0 1 0 0 1 1 1 1 Telethonin protein Interferon PF00143.17 001164843.1_49822001_1 - 5.5e-66 221.5 0.3 6.3e-66 221.3 0.3 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain DLIC PF05783.9 001244749.2_49824001_3 - 9.6e-10 37.7 0.1 7.7e-07 28.2 0.0 2.1 1 1 1 2 2 2 2 Dynein light intermediate chain (DLIC) Roc PF08477.11 001244749.2_49824001_3 - 0.11 12.6 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase STG PF15809.3 001128447.2_49823001_1 - 8.3e-109 363.1 27.8 1.4e-108 362.4 27.8 1.4 1 1 0 1 1 1 1 Simian taste bud-specific gene product family DUF1907 PF08925.9 001244696.1_49825001_2 - 6.8e-125 416.0 0.0 8.3e-125 415.8 0.0 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1907) DUF2358 PF10184.7 001243459.1_49823001_2 - 5.5e-33 113.5 1.4 7.2e-33 113.1 1.4 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) IL8 PF00048.18 001256775.2_49822001_3 - 8.8e-22 76.9 0.1 1.5e-21 76.1 0.1 1.4 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like MutS_V PF00488.19 001195357.1_49827001_2 - 5.2e-85 284.1 0.5 1e-84 283.2 0.5 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.16 001195357.1_49827001_2 - 3.6e-37 128.3 3.1 4.9e-37 127.8 1.4 2.1 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.15 001195357.1_49827001_2 - 1.3e-21 77.1 0.0 5.8e-21 75.1 0.0 2.1 2 0 0 2 2 2 1 MutS domain II MutS_I PF01624.18 001195357.1_49827001_2 - 2.3e-21 76.0 0.3 1.4e-20 73.5 0.0 2.6 3 0 0 3 3 3 1 MutS domain I MutS_IV PF05190.16 001195357.1_49827001_2 - 2.1e-20 72.7 0.9 6.5e-20 71.1 0.9 1.9 1 0 0 1 1 1 1 MutS family domain IV AAA_27 PF13514.4 001195357.1_49827001_2 - 0.002 17.6 0.0 0.0065 16.0 0.0 1.9 1 0 0 1 1 1 1 AAA domain ArdA PF07275.9 001195357.1_49827001_2 - 0.11 12.9 1.5 0.3 11.5 0.1 2.6 2 2 1 3 3 3 0 Antirestriction protein (ArdA) Lactamase_B_4 PF13691.4 001243216.1_49827001_2 - 3.6e-15 55.3 0.0 7.8e-15 54.2 0.0 1.6 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B_2 PF12706.5 001243216.1_49827001_2 - 8.6e-13 48.1 0.2 1.3e-10 41.0 0.9 2.8 3 1 0 3 3 3 2 Beta-lactamase superfamily domain Lactamase_B PF00753.25 001243216.1_49827001_2 - 0.0037 17.2 0.5 0.015 15.2 0.5 2.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Acyltransf_C PF16076.3 001143700.1_49823001_1 - 1.6e-26 92.1 0.2 3.1e-26 91.2 0.2 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus Acyltransferase PF01553.19 001143700.1_49823001_1 - 4.5e-14 52.1 0.0 7.2e-14 51.4 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Ank_2 PF12796.5 001315720.1_49823001_1 - 1.6e-36 124.6 5.2 1.9e-13 50.7 0.2 2.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001315720.1_49823001_1 - 1.2e-25 89.4 8.8 1.2e-09 38.4 0.1 3.5 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 001315720.1_49823001_1 - 4.7e-24 81.7 5.4 0.00042 20.4 0.0 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.4 001315720.1_49823001_1 - 2e-23 81.9 13.8 6.5e-12 45.3 0.5 4.3 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.28 001315720.1_49823001_1 - 9.3e-21 73.2 8.6 8.5e-05 22.7 0.3 5.3 5 0 0 5 5 5 4 Ankyrin repeat Atg8 PF02991.14 001190287.1_49824001_1 - 8.7e-48 160.7 0.2 1.2e-47 160.2 0.2 1.2 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.11 001190287.1_49824001_1 - 5.1e-07 29.9 0.0 8e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Ig_3 PF13927.4 001123086.1_49822001_3 - 2.6e-12 47.1 0.5 7.2e-09 36.0 0.2 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001123086.1_49822001_3 - 4e-11 43.0 0.0 3.7e-06 27.1 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001123086.1_49822001_3 - 4.2e-06 26.7 0.7 0.021 14.8 0.1 2.8 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001123086.1_49822001_3 - 8.6e-06 25.6 0.5 0.0001 22.2 0.1 2.4 2 1 0 2 2 2 1 Immunoglobulin I-set domain Ig_5 PF16681.3 001123086.1_49822001_3 - 1.2e-05 25.5 0.0 0.31 11.3 0.0 2.9 2 1 0 2 2 2 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set PF07686.15 001123086.1_49822001_3 - 0.00013 21.9 0.1 0.0044 17.0 0.1 2.8 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_4 PF16680.3 001123086.1_49822001_3 - 0.055 13.7 0.2 7.8 6.8 0.0 3.0 2 1 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain Mito_carr PF00153.25 001195115.2_49826001_1 - 6.3e-58 192.6 0.2 1.4e-20 72.9 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Dynactin_p62 PF05502.11 001244307.1_49828001_2 - 1.6e-35 122.7 20.8 9.5e-21 74.0 9.8 2.3 1 1 0 2 2 2 2 Dynactin p62 family BLOC1S3 PF15753.3 001098586.1_49822001_1 - 2.7e-43 147.9 0.0 3.3e-43 147.7 0.0 1.1 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex 1 subunit 3 Thymidylat_synt PF00303.17 001243579.1_49824001_2 - 7.4e-117 389.1 0.0 8.8e-117 388.8 0.0 1.1 1 0 0 1 1 1 1 Thymidylate synthase Defensin_beta PF00711.17 001129977.1_49822001_1 - 2.3e-09 37.0 6.4 4.9e-09 35.9 6.4 1.6 1 0 0 1 1 1 1 Beta defensin Defensin_beta_2 PF13841.4 001129977.1_49822001_1 - 0.00011 22.4 7.9 0.00022 21.5 7.9 1.5 1 0 0 1 1 1 1 Beta defensin Tetraspannin PF00335.18 001078679.1_49822001_1 - 5.3e-46 156.9 13.4 6.1e-46 156.8 13.4 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF21 PF01595.18 001078679.1_49822001_1 - 0.22 11.1 2.8 1.9 8.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF21 TGF_beta PF00019.18 001206388.1_49825001_2 - 5.2e-31 107.5 0.4 9.4e-31 106.7 0.4 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.16 001206388.1_49825001_2 - 8.5e-07 28.8 0.0 1.9e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 TGF-beta propeptide Abhydrolase_1 PF00561.18 001244243.2_49823001_1 - 3.2e-13 49.8 0.0 5.9e-07 29.2 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001244243.2_49823001_1 - 2.5e-09 38.0 5.1 1.5e-06 28.9 0.1 2.7 2 1 1 3 3 3 2 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 001244243.2_49823001_1 - 6.7e-09 35.2 0.0 0.00022 20.4 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 FSH1 PF03959.11 001244243.2_49823001_1 - 0.11 12.0 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 Serine hydrolase (FSH1) DLH PF01738.16 001244243.2_49823001_1 - 0.17 11.3 0.0 0.61 9.5 0.0 1.7 2 0 0 2 2 2 0 Dienelactone hydrolase family MARVEL PF01284.21 001243842.1_49825001_2 - 8.2e-08 32.3 8.9 1.1e-07 31.8 8.9 1.2 1 0 0 1 1 1 1 Membrane-associating domain Defensin_beta PF00711.17 214444.1_49821001_1 - 3.2e-09 36.6 10.2 6.7e-09 35.5 10.2 1.6 1 0 0 1 1 1 1 Beta defensin CD52 PF15116.4 001257355.1_49821001_2 - 5.7e-19 67.7 1.8 5.7e-19 67.7 1.8 1.9 2 0 0 2 2 2 1 CAMPATH-1 antigen Pkinase PF00069.23 001123099.1_49824001_3 - 6e-54 183.0 0.1 7.9e-54 182.6 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001123099.1_49824001_3 - 1.1e-24 87.1 0.0 4.2e-24 85.1 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase EMP24_GP25L PF01105.22 001202540.1_49823001_1 - 8.7e-50 169.1 0.3 1.1e-49 168.8 0.3 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD S-AdoMet_synt_C PF02773.14 001243187.1_49827001_1 - 2.2e-68 228.4 0.0 3.6e-68 227.7 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.14 001243187.1_49827001_1 - 3.4e-44 149.8 0.0 5.1e-44 149.2 0.0 1.3 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.18 001243187.1_49827001_1 - 7.5e-43 145.1 0.2 1.2e-42 144.4 0.2 1.3 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.17 001243187.1_49827001_1 - 0.11 11.1 0.0 0.22 10.1 0.0 1.3 1 0 0 1 1 1 0 S-adenosylmethionine synthetase (AdoMet synthetase) 7tm_1 PF00001.19 001001620.1_49824001_1 - 3.2e-47 160.9 19.7 6.6e-47 159.9 19.7 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001001620.1_49824001_1 - 3.9e-08 32.9 16.4 3.9e-08 32.9 16.4 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx Peptidase_C2 PF00648.19 001044529.1_49825001_3 - 1.1e-76 257.6 0.0 1.5e-76 257.1 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 001044529.1_49825001_3 - 4.1e-39 134.0 0.0 1.6e-20 73.7 0.0 2.3 2 0 0 2 2 2 2 Calpain large subunit, domain III DUF4604 PF15377.4 214143.1_49822001_1 - 0.012 15.9 15.4 0.015 15.6 15.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) OATP PF03137.18 214143.1_49822001_1 - 7.5 4.6 6.8 8.7 4.4 6.8 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Urotensin_II PF02083.13 214143.1_49822001_2 - 1.7e-05 24.1 1.8 3.2e-05 23.2 1.8 1.5 1 0 0 1 1 1 1 Urotensin II DUF4604 PF15377.4 214143.1_49822001_2 - 0.004 17.5 15.7 0.0051 17.1 15.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) SR-25 PF10500.7 214143.1_49822001_2 - 1.6 8.1 33.0 2 7.8 33.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AP3D1 PF06375.9 214143.1_49822001_2 - 4.1 7.5 27.4 6.4 6.9 27.4 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF4604 PF15377.4 214143.1_49822001_3 - 0.017 15.4 18.4 0.028 14.7 18.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) RNA_polI_A34 PF08208.9 214143.1_49822001_3 - 0.097 12.6 27.2 0.12 12.4 27.2 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Folate_carrier PF01770.16 214143.1_49822001_3 - 0.2 10.2 1.6 0.25 9.9 1.6 1.0 1 0 0 1 1 1 0 Reduced folate carrier Connexin PF00029.17 214143.1_49822001_3 - 0.76 9.4 5.7 1 8.9 5.7 1.2 1 0 0 1 1 1 0 Connexin Peptidase_S49_N PF08496.8 214143.1_49822001_3 - 2.3 8.2 17.4 3.1 7.7 17.4 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PRP3 PF08572.8 001135965.1_49825001_1 - 2.6e-78 262.7 7.7 2.6e-78 262.7 7.7 2.7 3 1 0 3 3 3 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.10 001135965.1_49825001_1 - 3.6e-48 163.2 1.9 3.6e-48 163.2 1.9 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) PWI PF01480.15 001135965.1_49825001_1 - 1.8e-13 50.4 0.0 3.9e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 PWI domain MdcG PF10620.7 001135965.1_49825001_1 - 4.4 6.9 5.9 1.7 8.2 2.6 1.9 2 0 0 2 2 2 0 Phosphoribosyl-dephospho-CoA transferase MdcG Methyltransf_32 PF13679.4 001135965.1_49825001_1 - 4.5 7.1 6.5 1.3 8.9 0.5 3.0 2 1 1 3 3 3 0 Methyltransferase domain ubiquitin PF00240.21 001204116.1_49821001_2 - 1.7e-06 27.5 0.2 4.1e-06 26.3 0.2 1.6 1 1 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.4 001204116.1_49821001_2 - 0.00013 22.2 0.1 0.00088 19.5 0.1 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain SH3_9 PF14604.4 001317083.1_49824001_1 - 1.3e-45 152.9 2.3 4.1e-15 55.2 0.1 3.4 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.26 001317083.1_49824001_1 - 8.9e-42 140.3 5.5 1.2e-14 53.5 0.2 3.4 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.15 001317083.1_49824001_1 - 3.6e-37 125.7 3.4 8.3e-14 50.9 0.1 3.4 3 0 0 3 3 3 3 Variant SH3 domain XFP PF03894.13 001317083.1_49824001_1 - 0.00066 19.3 0.0 4.4 6.9 0.0 3.2 3 0 0 3 3 3 2 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase Tmemb_cc2 PF10267.7 001317083.1_49824001_1 - 0.0048 16.0 0.4 0.0093 15.0 0.4 1.4 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein P63C PF10546.7 001317083.1_49824001_1 - 0.057 13.9 0.0 0.14 12.7 0.0 1.6 1 0 0 1 1 1 0 P63C domain betaPIX_CC PF16523.3 001317083.1_49824001_1 - 0.1 12.3 3.3 0.3 10.8 3.3 1.7 1 0 0 1 1 1 0 betaPIX coiled coil Baculo_PEP_C PF04513.10 001317083.1_49824001_1 - 0.16 11.9 0.2 0.3 11.0 0.2 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Tissue_fac PF01108.15 001204775.2_49826001_2 - 1.3e-21 76.3 0.4 3e-21 75.1 0.4 1.6 1 0 0 1 1 1 1 Tissue factor Interfer-bind PF09294.8 001204775.2_49826001_2 - 1.8e-15 57.0 0.2 4.8e-15 55.6 0.2 1.8 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III DUF2457 PF10446.7 001204775.2_49826001_2 - 0.34 9.9 20.9 0.66 8.9 20.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CDC45 PF02724.12 001204775.2_49826001_2 - 1.2 7.3 5.9 2.1 6.4 5.9 1.3 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.11 001204775.2_49826001_2 - 2.1 6.2 18.6 3 5.7 18.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.10 001204775.2_49826001_2 - 3 5.8 11.5 4.6 5.2 11.5 1.2 1 0 0 1 1 1 0 Nop14-like family Sporozoite_P67 PF05642.9 001204775.2_49826001_2 - 4.4 5.1 6.6 6.9 4.5 6.6 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SGT1 PF07093.9 001204775.2_49826001_2 - 5.9 5.1 6.1 9 4.5 6.1 1.1 1 0 0 1 1 1 0 SGT1 protein RXT2_N PF08595.9 001204775.2_49826001_2 - 7.5 6.4 8.9 2.1 8.3 4.8 2.0 2 0 0 2 2 2 0 RXT2-like, N-terminal Nic96 PF04097.12 001244152.1_49826001_1 - 1e-196 655.0 0.2 1.5e-196 654.4 0.2 1.2 1 0 0 1 1 1 1 Nup93/Nic96 Nup84_Nup100 PF04121.11 001244152.1_49826001_1 - 0.0046 15.1 0.3 0.0087 14.2 0.3 1.4 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 CBS PF00571.26 214077.1_49825001_1 - 2.9e-34 117.2 4.1 7.1e-11 42.3 0.2 4.4 4 0 0 4 4 4 4 CBS domain Patatin PF01734.20 001160082.1_49822001_3 - 7.8e-10 39.1 0.2 1.9e-08 34.6 0.1 2.1 1 1 1 2 2 2 2 Patatin-like phospholipase WRNPLPNID PF15017.4 001244607.1_49824001_1 - 1.5e-21 76.8 2.6 7.5e-18 65.0 0.3 2.2 1 1 1 2 2 2 2 Putative WW-binding domain and destruction box AIMP2_LysRS_bd PF16780.3 214357.1_49826001_1 - 0.016 14.8 0.1 0.19 11.4 0.0 2.3 2 0 0 2 2 2 0 AIMP2 lysyl-tRNA synthetase binding domain LRR_8 PF13855.4 214357.1_49826001_3 - 1e-47 159.6 65.8 1.9e-09 37.0 0.9 10.3 5 3 6 11 11 11 10 Leucine rich repeat LRR_4 PF12799.5 214357.1_49826001_3 - 3.4e-18 65.2 62.9 0.00022 21.4 3.0 11.8 4 3 11 15 15 15 12 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 214357.1_49826001_3 - 8e-06 25.7 12.5 0.31 10.9 0.8 5.5 2 2 2 5 5 5 3 Leucine rich repeats (6 copies) LRR_1 PF00560.31 214357.1_49826001_3 - 0.00031 20.7 64.1 0.19 12.2 0.1 15.9 15 3 0 15 15 15 2 Leucine Rich Repeat LRR_9 PF14580.4 214357.1_49826001_3 - 0.014 14.8 15.0 3 7.2 0.0 5.3 2 2 4 7 7 7 0 Leucine-rich repeat LRRCT PF01463.22 214357.1_49826001_3 - 0.029 14.8 0.2 0.16 12.4 0.0 2.5 2 0 0 2 2 2 0 Leucine rich repeat C-terminal domain LRR_6 PF13516.4 214357.1_49826001_3 - 0.069 13.1 51.2 1.9 8.6 0.0 12.1 13 0 0 13 13 13 0 Leucine Rich repeat LRRNT PF01462.16 214357.1_49826001_3 - 4 7.1 5.9 0.93 9.1 0.0 3.0 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain Peptidase_M1 PF01433.18 001185132.2_49825001_3 - 2.5e-78 264.0 0.0 3.4e-78 263.5 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M1 Leuk-A4-hydro_C PF09127.9 001185132.2_49825001_3 - 4.6e-46 156.2 0.4 7.7e-46 155.5 0.4 1.4 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal DUF4367 PF14285.4 001185132.2_49825001_3 - 0.059 13.7 0.3 0.2 12.0 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4367) Peptidase_M48 PF01435.16 001185132.2_49825001_3 - 0.14 11.8 0.0 0.29 10.7 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M48 HSBP1 PF06825.10 001136184.1_49822001_2 - 7.9e-16 57.6 0.7 1.2e-15 57.0 0.7 1.3 1 0 0 1 1 1 1 Heat shock factor binding protein 1 Metal_resist PF13801.4 001136184.1_49822001_2 - 0.00048 20.2 1.6 0.00081 19.4 1.6 1.3 1 0 0 1 1 1 1 Heavy-metal resistance Apolipoprotein PF01442.16 001136184.1_49822001_2 - 0.051 13.4 0.3 0.072 12.9 0.3 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain LIME1 PF15332.4 001244490.1_49823001_3 - 3.2e-81 272.1 4.5 1.1e-79 267.0 0.1 2.2 1 1 1 2 2 2 2 Lck-interacting transmembrane adapter 1 BST2 PF16716.3 001161755.1_49822001_1 - 1.1e-31 109.1 19.4 1.4e-31 108.7 19.4 1.1 1 0 0 1 1 1 1 Bone marrow stromal antigen 2 Spc7 PF08317.9 001161755.1_49822001_1 - 7e-06 25.0 8.7 8.5e-06 24.7 8.7 1.0 1 0 0 1 1 1 1 Spc7 kinetochore protein IncA PF04156.12 001161755.1_49822001_1 - 6e-05 22.8 15.3 6e-05 22.8 15.3 1.7 1 1 1 2 2 2 1 IncA protein DUF3450 PF11932.6 001161755.1_49822001_1 - 0.00074 18.8 7.3 0.00093 18.4 7.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) DUF4337 PF14235.4 001161755.1_49822001_1 - 0.0014 18.6 4.5 0.0017 18.3 4.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4337) CALCOCO1 PF07888.9 001161755.1_49822001_1 - 0.0017 16.9 8.7 0.0021 16.6 8.7 1.0 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like AAA_13 PF13166.4 001161755.1_49822001_1 - 0.0021 16.7 3.8 0.0026 16.4 3.8 1.0 1 0 0 1 1 1 1 AAA domain GrpE PF01025.17 001161755.1_49822001_1 - 0.0029 17.1 10.1 0.0054 16.3 3.2 2.1 1 1 1 2 2 2 1 GrpE 60KD_IMP PF02096.18 001161755.1_49822001_1 - 0.0037 17.0 3.0 0.03 14.1 0.9 2.1 1 1 1 2 2 2 1 60Kd inner membrane protein SOG2 PF10428.7 001161755.1_49822001_1 - 0.0043 16.2 5.1 0.0052 16.0 5.1 1.1 1 0 0 1 1 1 1 RAM signalling pathway protein Golgin_A5 PF09787.7 001161755.1_49822001_1 - 0.0045 16.4 10.1 0.0061 15.9 10.1 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 5 MCU PF04678.11 001161755.1_49822001_1 - 0.0046 17.0 3.2 0.0046 17.0 3.2 1.5 2 0 0 2 2 1 1 Mitochondrial calcium uniporter GAS PF13851.4 001161755.1_49822001_1 - 0.0076 15.5 16.3 0.013 14.7 7.3 2.0 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding HAUS-augmin3 PF14932.4 001161755.1_49822001_1 - 0.011 15.2 8.6 0.014 14.8 8.6 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 RmuC PF02646.14 001161755.1_49822001_1 - 0.011 14.7 7.3 0.011 14.7 7.3 1.5 1 1 0 1 1 1 0 RmuC family Glycoprotein_G PF00802.17 001161755.1_49822001_1 - 0.012 14.9 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 0 Pneumovirus attachment glycoprotein G Jnk-SapK_ap_N PF09744.7 001161755.1_49822001_1 - 0.013 15.6 14.4 0.018 15.1 14.4 1.1 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 APG6 PF04111.10 001161755.1_49822001_1 - 0.014 14.6 10.6 0.02 14.2 10.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Prefoldin_2 PF01920.18 001161755.1_49822001_1 - 0.019 14.8 7.4 0.019 14.8 7.4 2.1 2 0 0 2 2 2 0 Prefoldin subunit DUF342 PF03961.11 001161755.1_49822001_1 - 0.02 13.4 3.7 0.024 13.1 3.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Baculo_p24 PF05073.10 001161755.1_49822001_1 - 0.022 14.4 3.0 0.028 14.1 3.0 1.1 1 0 0 1 1 1 0 Baculovirus P24 capsid protein V_ATPase_I PF01496.17 001161755.1_49822001_1 - 0.027 12.2 5.1 0.034 11.9 5.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ARD PF03079.12 001161755.1_49822001_1 - 0.027 14.5 1.7 0.031 14.3 1.1 1.4 1 1 0 1 1 1 0 ARD/ARD' family DUF5082 PF16888.3 001161755.1_49822001_1 - 0.031 14.5 9.5 0.035 14.3 6.6 2.2 1 1 2 3 3 3 0 Domain of unknown function (DUF5082) Nitrate_red_del PF02613.13 001161755.1_49822001_1 - 0.036 13.9 1.6 4.2 7.3 0.4 2.2 1 1 1 2 2 2 0 Nitrate reductase delta subunit DUF812 PF05667.9 001161755.1_49822001_1 - 0.042 12.6 9.1 0.056 12.2 9.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) EzrA PF06160.10 001161755.1_49822001_1 - 0.048 11.7 9.7 0.068 11.2 9.7 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA CENP-H PF05837.10 001161755.1_49822001_1 - 0.062 13.6 10.9 0.086 13.1 10.9 1.2 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Exonuc_VII_L PF02601.13 001161755.1_49822001_1 - 0.064 12.7 6.8 0.075 12.5 6.8 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Val_tRNA-synt_C PF10458.7 001161755.1_49822001_1 - 0.066 13.4 3.2 0.066 13.4 3.2 3.0 1 1 2 3 3 3 0 Valyl tRNA synthetase tRNA binding arm Mnd1 PF03962.13 001161755.1_49822001_1 - 0.076 12.7 10.9 0.1 12.3 10.9 1.1 1 0 0 1 1 1 0 Mnd1 family CcmE PF03100.13 001161755.1_49822001_1 - 0.1 12.5 0.3 0.23 11.3 0.2 1.7 1 1 0 1 1 1 0 CcmE AI-2E_transport PF01594.14 001161755.1_49822001_1 - 0.11 11.5 3.1 0.25 10.3 0.1 2.0 1 1 1 2 2 2 0 AI-2E family transporter WXG100 PF06013.10 001161755.1_49822001_1 - 0.12 12.5 8.7 0.22 11.6 1.4 2.3 1 1 1 2 2 2 0 Proteins of 100 residues with WXG Borrelia_P83 PF05262.9 001161755.1_49822001_1 - 0.17 10.2 8.2 0.21 9.9 8.2 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein TMEM132D_C PF15706.3 001161755.1_49822001_1 - 0.17 11.5 0.9 0.29 10.8 0.3 1.7 1 1 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term TPR_MLP1_2 PF07926.10 001161755.1_49822001_1 - 0.2 11.6 16.2 0.41 10.6 12.9 1.8 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein tRNA-synt_1c PF00749.19 001161755.1_49822001_1 - 0.23 10.2 3.5 0.28 9.9 3.5 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain FlxA PF14282.4 001161755.1_49822001_1 - 0.24 11.2 19.0 13 5.7 19.1 2.1 1 1 0 1 1 1 0 FlxA-like protein Prefoldin PF02996.15 001161755.1_49822001_1 - 0.26 11.1 13.4 1.3 8.9 5.6 2.1 1 1 1 2 2 2 0 Prefoldin subunit DUF1664 PF07889.10 001161755.1_49822001_1 - 0.27 11.1 8.7 1.1 9.2 2.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ADIP PF11559.6 001161755.1_49822001_1 - 0.27 11.2 17.2 0.73 9.8 16.2 1.8 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF1043 PF06295.10 001161755.1_49822001_1 - 0.33 10.8 10.1 2 8.3 9.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) ERM PF00769.17 001161755.1_49822001_1 - 0.36 10.5 17.7 0.83 9.3 17.7 1.5 1 1 0 1 1 1 0 Ezrin/radixin/moesin family Uso1_p115_C PF04871.11 001161755.1_49822001_1 - 0.37 11.0 13.4 0.49 10.6 13.4 1.1 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Med9 PF07544.11 001161755.1_49822001_1 - 0.38 10.7 11.5 7.4 6.6 11.3 2.1 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 FliJ PF02050.14 001161755.1_49822001_1 - 0.44 10.6 16.7 0.68 10.0 16.7 1.2 1 0 0 1 1 1 0 Flagellar FliJ protein DUF2730 PF10805.6 001161755.1_49822001_1 - 0.47 10.4 4.5 0.83 9.6 4.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) HIP1_clath_bdg PF16515.3 001161755.1_49822001_1 - 0.48 10.9 17.3 0.41 11.2 13.6 2.0 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 TMPIT PF07851.11 001161755.1_49822001_1 - 0.65 9.0 11.8 0.22 10.6 8.7 1.7 1 1 1 2 2 2 0 TMPIT-like protein Laminin_II PF06009.10 001161755.1_49822001_1 - 0.73 9.7 8.0 1.7 8.6 1.1 1.9 1 1 1 2 2 2 0 Laminin Domain II HrpB7 PF09486.8 001161755.1_49822001_1 - 0.84 9.9 11.7 2.5 8.4 3.6 2.1 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) LPP PF04728.11 001161755.1_49822001_1 - 0.87 9.9 4.6 0.52 10.6 1.5 2.0 1 1 1 2 2 2 0 Lipoprotein leucine-zipper DUF724 PF05266.12 001161755.1_49822001_1 - 0.9 9.2 9.1 1.2 8.8 9.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF641 PF04859.10 001161755.1_49822001_1 - 1.1 9.4 12.7 3.6 7.8 5.3 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) PRKG1_interact PF15898.3 001161755.1_49822001_1 - 1.5 9.7 13.5 2.3 9.0 1.4 2.0 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain CCDC-167 PF15188.4 001161755.1_49822001_1 - 1.5 9.1 10.9 0.59 10.4 7.9 1.9 2 1 0 2 2 1 0 Coiled-coil domain-containing protein 167 MADF_DNA_bdg PF10545.7 001161755.1_49822001_1 - 1.5 9.0 5.4 1.7 8.9 2.8 2.1 1 1 1 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Rho_Binding PF08912.9 001161755.1_49822001_1 - 1.7 9.4 14.0 12 6.7 7.2 2.2 1 1 1 2 2 2 0 Rho Binding DUF3573 PF12097.6 001161755.1_49822001_1 - 1.7 7.3 5.1 3.1 6.4 5.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3573) THOC7 PF05615.11 001161755.1_49822001_1 - 1.9 8.6 15.3 12 6.0 15.6 1.7 1 1 1 2 2 2 0 Tho complex subunit 7 OmpH PF03938.12 001161755.1_49822001_1 - 2 8.2 17.3 4.4 7.1 17.4 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) SlyX PF04102.10 001161755.1_49822001_1 - 2.1 8.9 16.2 0.56 10.7 6.6 2.2 1 1 1 2 2 2 0 SlyX EMP24_GP25L PF01105.22 001161755.1_49822001_1 - 2.2 8.0 10.6 0.31 10.8 5.7 2.1 1 1 0 2 2 1 0 emp24/gp25L/p24 family/GOLD Ly49 PF08391.8 001161755.1_49822001_1 - 2.3 8.5 13.6 0.47 10.7 8.9 2.2 1 1 1 2 2 1 0 Ly49-like protein, N-terminal region Med21 PF11221.6 001161755.1_49822001_1 - 2.5 8.2 14.8 16 5.6 14.8 1.8 1 1 0 1 1 1 0 Subunit 21 of Mediator complex SNARE PF05739.17 001161755.1_49822001_1 - 2.7 8.0 5.7 2.6 8.0 0.3 3.1 2 1 0 2 2 2 0 SNARE domain Alanine_zipper PF11839.6 001161755.1_49822001_1 - 3 8.0 9.5 1 9.5 1.8 2.3 1 1 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein HR1 PF02185.14 001161755.1_49822001_1 - 4.7 7.3 14.9 0.8 9.7 9.3 2.3 1 1 1 2 2 2 0 Hr1 repeat DUF745 PF05335.11 001161755.1_49822001_1 - 4.8 6.8 13.5 8.2 6.0 13.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF745) Spc24 PF08286.9 001161755.1_49822001_1 - 5.3 7.2 13.6 2.8 8.1 7.5 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF4140 PF13600.4 001161755.1_49822001_1 - 6.4 7.2 11.5 1.9 8.8 4.9 2.1 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) USP8_interact PF08941.8 001161755.1_49822001_1 - 7.3 6.2 9.6 4.6 6.9 1.9 2.1 1 1 1 2 2 2 0 USP8 interacting Bap31 PF05529.10 001161755.1_49822001_1 - 7.9 5.9 14.4 24 4.4 14.4 1.8 1 1 0 1 1 1 0 B-cell receptor-associated protein 31-like Swi5 PF07061.9 001161755.1_49822001_1 - 9.2 6.3 10.1 7.3 6.6 3.6 2.2 1 1 1 2 2 2 0 Swi5 DUF2968 PF11180.6 001161755.1_49822001_1 - 9.2 5.8 17.6 18 4.9 16.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2968) p450 PF00067.20 214417.1_49824001_2 - 4e-145 484.0 0.3 4.5e-145 483.8 0.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.23 001204767.1_49824001_2 - 1.5e-37 129.3 0.0 2.6e-37 128.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001204767.1_49824001_2 - 1.7e-37 129.0 0.0 2.7e-37 128.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase TGF_beta_GS PF08515.10 001204767.1_49824001_2 - 5.8e-16 57.5 0.7 1.2e-15 56.5 0.7 1.6 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Activin_recp PF01064.21 001204767.1_49824001_2 - 4.3e-12 46.8 13.5 4.3e-12 46.8 13.5 1.9 2 0 0 2 2 2 1 Activin types I and II receptor domain FTA2 PF13095.4 001204767.1_49824001_2 - 0.03 13.8 0.0 0.056 12.9 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.21 001204767.1_49824001_2 - 0.16 11.8 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family PH PF00169.27 001253821.1_49826001_1 - 4.7e-25 88.0 3.9 1.4e-12 47.9 0.3 2.9 3 0 0 3 3 3 2 PH domain PH_11 PF15413.4 001253821.1_49826001_1 - 6.7e-06 26.3 0.6 0.17 12.2 0.0 3.8 3 1 0 3 3 3 2 Pleckstrin homology domain PH_9 PF15410.4 001253821.1_49826001_1 - 2.1e-05 24.7 1.0 0.93 9.7 0.5 4.2 2 2 0 2 2 2 2 Pleckstrin homology domain Sharpin_PH PF16764.3 001253821.1_49826001_1 - 0.0033 17.1 0.2 0.011 15.4 0.0 1.9 2 0 0 2 2 2 1 Sharpin PH domain Spc7 PF08317.9 001253821.1_49826001_1 - 0.051 12.3 9.1 0.096 11.4 9.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein IncA PF04156.12 001253821.1_49826001_1 - 0.48 10.1 11.1 1.2 8.8 11.1 1.5 1 0 0 1 1 1 0 IncA protein Prefoldin_2 PF01920.18 001253821.1_49826001_1 - 0.56 10.1 14.1 0.24 11.3 5.9 2.9 2 0 0 2 2 2 0 Prefoldin subunit Enkurin PF13864.4 001253821.1_49826001_1 - 1.8 8.9 13.0 4.2 7.7 8.7 3.2 2 1 0 2 2 2 0 Calmodulin-binding 7tm_1 PF00001.19 001315817.1_49823001_1 - 4.1e-31 108.1 11.2 7.5e-31 107.2 11.2 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001315817.1_49823001_1 - 3e-06 27.0 8.3 0.00016 21.4 8.3 2.4 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001315817.1_49823001_1 - 0.17 11.1 5.6 0.3 10.3 5.6 1.5 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx RrnaAD PF00398.18 001244313.1_49824001_3 - 1.3e-64 217.7 0.0 1.7e-64 217.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.4 001244313.1_49824001_3 - 2.3e-07 31.3 0.0 4.5e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001244313.1_49824001_3 - 8.3e-05 23.0 0.0 0.00016 22.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.17 001244313.1_49824001_3 - 0.0014 18.3 0.0 0.0023 17.6 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.4 001244313.1_49824001_3 - 0.015 15.1 0.0 0.029 14.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.14 001244313.1_49824001_3 - 0.015 14.9 0.0 0.024 14.3 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_2 PF00891.16 001244313.1_49824001_3 - 0.017 14.2 0.0 0.029 13.5 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_12 PF08242.10 001244313.1_49824001_3 - 0.022 15.4 0.0 0.046 14.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.5 001244313.1_49824001_3 - 0.045 13.6 0.0 0.099 12.4 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain CMAS PF02353.18 001244313.1_49824001_3 - 0.082 12.1 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase MTS PF05175.12 001244313.1_49824001_3 - 0.12 11.8 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Orn_Arg_deC_N PF02784.14 001122983.1_49823001_1 - 1.1e-88 296.7 0.0 1.4e-88 296.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001122983.1_49823001_1 - 3.7e-35 120.2 0.0 1.3e-34 118.5 0.0 1.9 2 0 0 2 2 2 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Vps26 PF03643.13 001137634.1_49826001_2 - 2.6e-131 436.5 5.9 3.3e-131 436.2 5.9 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.27 001137634.1_49826001_2 - 0.0082 16.1 0.4 2.5 8.0 0.0 2.7 2 1 1 3 3 3 2 Arrestin (or S-antigen), N-terminal domain Ig_2 PF13895.4 001243873.1_49823001_1 - 4.5e-11 42.8 0.6 0.00014 22.0 0.1 2.9 3 0 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.4 001243873.1_49823001_1 - 4.4e-07 30.3 1.3 0.00018 21.9 0.0 2.9 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.23 001243873.1_49823001_1 - 6.5e-07 29.3 0.1 2.5e-06 27.4 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin domain DUF4448 PF14610.4 001243873.1_49823001_1 - 0.012 15.3 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) SIT PF15330.4 001243873.1_49823001_1 - 0.071 13.4 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Zip PF02535.20 001244460.1_49823001_1 - 1.4e-62 211.8 15.1 3.1e-40 138.3 10.4 2.0 1 1 1 2 2 2 2 ZIP Zinc transporter Cpn60_TCP1 PF00118.22 001278779.1_49825001_2 - 3.1e-160 533.9 7.4 3.8e-160 533.6 7.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF5133 PF17196.2 001278779.1_49825001_3 - 0.006 16.6 0.4 0.018 15.1 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF5133) NDUF_B8 PF05821.9 001144842.2_49822001_2 - 1e-81 272.9 7.2 1.2e-81 272.7 7.2 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) DLIC PF05783.9 001243620.1_49824001_3 - 1.7e-257 854.6 0.0 2e-257 854.4 0.0 1.0 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) ABC_tran PF00005.25 001243620.1_49824001_3 - 0.0025 18.2 0.0 0.0057 17.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.4 001243620.1_49824001_3 - 0.0098 16.0 0.0 0.027 14.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 001243620.1_49824001_3 - 0.012 15.9 0.0 0.022 15.0 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Arf PF00025.19 001243620.1_49824001_3 - 0.013 14.8 0.1 0.13 11.6 0.0 2.4 3 0 0 3 3 3 0 ADP-ribosylation factor family PduV-EutP PF10662.7 001243620.1_49824001_3 - 0.03 13.9 0.2 0.074 12.7 0.2 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Roc PF08477.11 001243620.1_49824001_3 - 0.032 14.3 0.1 0.12 12.5 0.0 1.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF258 PF03193.14 001243620.1_49824001_3 - 0.033 14.0 0.2 3 7.6 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_24 PF13479.4 001243620.1_49824001_3 - 0.034 13.7 0.3 0.058 13.0 0.3 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.4 001243620.1_49824001_3 - 0.038 13.6 0.3 0.1 12.2 0.3 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.10 001243620.1_49824001_3 - 0.062 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Kinesin PF00225.21 001243620.1_49824001_3 - 0.073 11.8 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Kinesin motor domain AAA_25 PF13481.4 001243620.1_49824001_3 - 0.086 12.3 0.0 0.45 9.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain ATPase PF06745.11 001243620.1_49824001_3 - 0.096 11.9 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 KaiC G-alpha PF00503.18 001243620.1_49824001_3 - 0.11 11.5 0.0 0.21 10.6 0.0 1.4 1 0 0 1 1 1 0 G-protein alpha subunit Lactamase_B_2 PF12706.5 001243185.1_49827001_3 - 0.026 13.9 0.0 0.055 12.9 0.0 1.5 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.3 001243185.1_49827001_3 - 0.029 13.7 0.0 0.044 13.1 0.0 1.2 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain Syntaxin-6_N PF09177.9 001243720.1_49825001_1 - 7.7e-38 128.9 0.9 7.7e-38 128.9 0.9 2.1 2 1 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.17 001243720.1_49825001_1 - 5.7e-12 45.3 1.1 5.7e-12 45.3 1.1 2.6 3 0 0 3 3 3 1 SNARE domain FliD_C PF07195.10 001243720.1_49825001_1 - 0.0035 16.7 1.7 0.082 12.2 0.0 2.2 2 1 0 2 2 2 1 Flagellar hook-associated protein 2 C-terminus Prominin PF05478.9 001243720.1_49825001_1 - 0.15 9.8 4.6 0.6 7.8 4.2 1.8 1 1 1 2 2 2 0 Prominin TBPIP PF07106.11 001243720.1_49825001_1 - 1.4 8.5 6.8 0.26 10.9 0.2 2.1 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DLH PF01738.16 001244350.1_49823001_2 - 1.9e-37 128.8 0.0 2.2e-37 128.6 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.19 001244350.1_49823001_2 - 1.6e-06 27.6 0.2 0.0032 16.9 0.0 2.2 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_2 PF02230.14 001244350.1_49823001_2 - 7.3e-05 22.5 0.0 0.00013 21.7 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.18 001244350.1_49823001_2 - 0.0015 18.1 0.1 0.13 11.8 0.0 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold FSH1 PF03959.11 001244350.1_49823001_2 - 0.0019 17.8 0.0 0.0059 16.2 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Hydrolase_4 PF12146.6 001244350.1_49823001_2 - 0.0025 17.0 0.0 1.4 7.9 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 BAAT_C PF08840.9 001244350.1_49823001_2 - 0.0077 16.0 0.1 0.67 9.7 0.0 2.2 1 1 1 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal DUF915 PF06028.9 001244350.1_49823001_2 - 0.029 13.6 0.0 0.061 12.5 0.0 1.5 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_5 PF12695.5 001244350.1_49823001_2 - 0.055 13.1 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_4 PF08386.8 001244350.1_49823001_2 - 0.098 12.6 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 TAP-like protein Abhydrolase_3 PF07859.11 001244350.1_49823001_2 - 0.16 11.6 0.0 3.2 7.4 0.0 2.1 1 1 1 2 2 2 0 alpha/beta hydrolase fold zf-RING_UBOX PF13445.4 001244359.1_49823001_1 - 2.5e-10 40.1 4.6 6.7e-10 38.7 4.6 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 001244359.1_49823001_1 - 6e-08 32.3 3.5 6e-08 32.3 3.5 2.6 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001244359.1_49823001_1 - 3.4e-07 29.9 4.8 3.4e-07 29.9 4.8 2.6 2 2 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001244359.1_49823001_1 - 7.9e-07 28.8 5.5 7.9e-07 28.8 5.5 2.6 3 0 0 3 3 2 1 zinc-RING finger domain zf-B_box PF00643.22 001244359.1_49823001_1 - 3.6e-06 26.9 7.8 3.6e-06 26.9 7.8 3.5 4 0 0 4 4 4 1 B-box zinc finger zf-RING_2 PF13639.4 001244359.1_49823001_1 - 7.9e-06 25.9 7.6 7.9e-06 25.9 7.6 2.5 2 1 0 2 2 1 1 Ring finger domain zf-C3HC4_4 PF15227.4 001244359.1_49823001_1 - 1.4e-05 25.0 6.9 1.4e-05 25.0 6.9 2.9 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 001244359.1_49823001_1 - 7.2e-05 22.4 9.5 7.2e-05 22.4 9.5 3.0 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 001244359.1_49823001_1 - 0.00014 21.5 0.3 0.00014 21.5 0.3 2.2 2 0 0 2 2 2 1 zf-RING of BARD1-type protein DUF349 PF03993.10 001244359.1_49823001_1 - 0.0061 16.7 1.7 0.0069 16.5 0.4 1.9 2 0 0 2 2 1 1 Domain of Unknown Function (DUF349) UvrD_C PF13361.4 001244359.1_49823001_1 - 0.039 13.2 0.4 0.056 12.7 0.4 1.1 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF2884 PF11101.6 001244359.1_49823001_1 - 0.048 13.0 3.6 0.031 13.6 1.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2884) Fmp27_WPPW PF10359.7 001244359.1_49823001_1 - 0.093 11.4 1.6 0.13 11.0 1.6 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF2431 PF10354.7 001244359.1_49823001_1 - 0.15 12.2 0.1 0.27 11.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) vATP-synt_E PF01991.16 001244359.1_49823001_1 - 0.43 9.8 6.9 1.8 7.8 7.0 1.8 1 1 1 2 2 2 0 ATP synthase (E/31 kDa) subunit Spectrin PF00435.19 001244359.1_49823001_1 - 0.64 10.4 5.3 0.22 11.9 0.6 2.3 2 0 0 2 2 2 0 Spectrin repeat DUF4571 PF15137.4 001163696.1_49823001_1 - 4.6e-105 350.0 0.2 5.7e-105 349.6 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4571) Choline_kinase PF01633.18 001206360.1_49824001_1 - 3.9e-71 238.9 0.0 5.3e-71 238.5 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.21 001206360.1_49824001_1 - 6.6e-12 45.7 0.0 1.7e-11 44.3 0.0 1.7 2 1 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.18 001206360.1_49824001_1 - 0.0006 19.1 0.0 0.0013 18.0 0.0 1.4 1 1 0 1 1 1 1 Ecdysteroid kinase MIP PF00230.18 001112683.1_49822001_1 - 1.4e-50 172.0 9.5 1.8e-50 171.7 9.5 1.0 1 0 0 1 1 1 1 Major intrinsic protein RnaseA PF00074.18 001244471.1_49822001_2 - 3.5e-06 27.4 2.6 5.6e-06 26.7 2.6 1.2 1 0 0 1 1 1 1 Pancreatic ribonuclease ADH_N PF08240.10 001315670.1_49829001_3 - 9.1e-24 83.3 0.2 1.4e-23 82.7 0.2 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.24 001315670.1_49829001_3 - 5.5e-20 71.5 0.6 8.6e-20 70.8 0.6 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.3 001315670.1_49829001_3 - 5e-05 22.8 0.0 0.00011 21.6 0.0 1.5 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.4 001315670.1_49829001_3 - 0.00043 21.2 0.0 0.00068 20.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase RPE65 PF03055.13 001136512.1_49825001_2 - 3.6e-107 359.0 0.1 4.2e-107 358.8 0.1 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Peptidase_C14 PF00656.20 001037147.1_49823001_1 - 1.1e-26 94.2 0.0 1.3e-26 93.9 0.0 1.1 1 0 0 1 1 1 1 Caspase domain PYRIN PF02758.14 001037147.1_49823001_1 - 2.2e-11 43.7 0.2 4.5e-11 42.7 0.2 1.5 1 0 0 1 1 1 1 PAAD/DAPIN/Pyrin domain DUF1256 PF06866.9 001037147.1_49823001_1 - 0.018 14.3 0.0 0.035 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1256) FBA PF04300.11 001244632.1_49824001_2 - 6.8e-76 254.0 0.0 8.7e-76 253.6 0.0 1.1 1 0 0 1 1 1 1 F-box associated region F-box-like PF12937.5 001244632.1_49824001_2 - 3.6e-08 33.0 5.6 8.8e-08 31.8 5.6 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001244632.1_49824001_2 - 3e-07 30.0 4.4 6.3e-07 29.0 4.4 1.6 1 0 0 1 1 1 1 F-box domain PQ-loop PF04193.12 001044619.1_49823001_2 - 3.1e-21 74.7 3.5 3.4e-13 49.0 0.7 2.7 3 0 0 3 3 3 2 PQ loop repeat DUF746 PF05344.9 001113017.1_49822001_1 - 0.027 14.2 1.2 0.29 10.9 0.1 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF746) RGS PF00615.17 001113017.1_49822001_2 - 7.9e-35 119.5 1.1 1e-34 119.2 1.1 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain Arteri_nsp7a PF16749.3 001113017.1_49822001_2 - 0.048 13.7 0.3 0.075 13.1 0.3 1.3 1 0 0 1 1 1 0 Arterivirus nonstructural protein 7 alpha Interfer-bind PF09294.8 213771.1_49823001_1 - 1.5e-28 99.0 0.0 2.6e-28 98.2 0.0 1.4 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III Tissue_fac PF01108.15 213771.1_49823001_1 - 1.9e-15 56.5 3.0 2.6e-14 52.8 0.0 2.9 2 1 0 2 2 2 1 Tissue factor fn3 PF00041.19 213771.1_49823001_1 - 0.022 15.0 0.4 0.47 10.7 0.3 2.6 2 1 0 2 2 2 0 Fibronectin type III domain zf-MIZ PF02891.18 213771.1_49823001_1 - 0.091 12.4 0.1 0.56 9.9 0.0 2.3 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger V-set PF07686.15 213795.1_49822001_1 - 8.8e-05 22.5 0.0 0.00019 21.4 0.0 1.6 2 0 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.23 213795.1_49822001_1 - 0.00024 21.1 0.0 0.00099 19.1 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.4 213795.1_49822001_1 - 0.0032 17.9 0.2 0.023 15.2 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 213795.1_49822001_1 - 0.014 15.3 0.0 0.036 14.0 0.0 1.7 2 0 0 2 2 2 0 Immunoglobulin I-set domain PP-binding PF00550.23 001167652.1_49821001_1 - 5e-12 45.9 0.1 7.1e-12 45.4 0.1 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site MinE PF03776.12 001167652.1_49821001_1 - 0.016 15.1 0.0 0.027 14.3 0.0 1.4 1 0 0 1 1 1 0 Septum formation topological specificity factor MinE PP-binding_2 PF14573.4 001167652.1_49821001_1 - 0.019 15.1 0.3 0.024 14.7 0.3 1.2 1 0 0 1 1 1 0 Acyl-carrier PseudoU_synth_1 PF01416.18 001244722.1_49824001_1 - 1.7e-32 111.9 0.1 7.6e-31 106.6 0.0 2.5 2 0 0 2 2 2 1 tRNA pseudouridine synthase Fmp27_WPPW PF10359.7 001244722.1_49824001_1 - 0.0045 15.8 0.5 0.0068 15.2 0.5 1.2 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF1192 PF06698.9 001244722.1_49824001_1 - 0.058 13.3 2.2 0.14 12.1 2.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) DUF3373 PF11853.6 001244722.1_49824001_1 - 0.065 11.8 0.1 0.089 11.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) DUF1956 PF09209.9 001244722.1_49824001_1 - 0.14 12.0 0.4 0.51 10.2 0.1 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1956) DivIC PF04977.13 001244722.1_49824001_1 - 7.9 6.2 8.2 2.4 7.8 1.0 2.9 3 0 0 3 3 3 0 Septum formation initiator Phospholip_B PF04916.11 001244629.1_49825001_2 - 7.7e-191 635.1 3.3 9.1e-191 634.9 3.3 1.0 1 0 0 1 1 1 1 Phospholipase B FixQ PF05545.9 001244629.1_49825001_3 - 0.12 12.2 0.5 0.23 11.3 0.5 1.4 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ IL8 PF00048.18 001134345.1_49821001_3 - 8.6e-13 48.1 0.3 8.6e-13 48.1 0.3 1.8 2 0 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like TPT PF03151.14 001244475.1_49823001_1 - 4.3e-21 75.4 12.3 5.1e-21 75.1 12.3 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.18 001244475.1_49823001_1 - 2.1e-07 31.1 30.8 0.00058 19.9 12.3 2.2 2 0 0 2 2 2 2 EamA-like transporter family MASE2 PF05230.9 001244475.1_49823001_3 - 0.023 14.7 0.1 0.042 13.8 0.1 1.3 1 0 0 1 1 1 0 MASE2 domain Glyco_hydro_18 PF00704.26 001258377.1_49824001_1 - 8.8e-95 317.9 4.0 1.1e-94 317.6 4.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_14 PF01607.22 001258377.1_49824001_1 - 2.4e-09 37.1 7.7 4.4e-09 36.2 7.7 1.5 1 0 0 1 1 1 1 Chitin binding Peritrophin-A domain Serglycin PF04360.10 001258377.1_49824001_1 - 0.29 10.9 4.8 0.68 9.7 4.8 1.6 1 0 0 1 1 1 0 Serglycin adh_short PF00106.23 001185137.1_49823001_1 - 6.3e-23 81.1 0.0 1.9e-21 76.3 0.0 2.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001185137.1_49823001_1 - 1.6e-11 44.1 0.0 1.3e-07 31.4 0.0 2.3 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001185137.1_49823001_1 - 2.2e-08 34.1 0.1 1.1e-07 31.8 0.0 2.0 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.4 001185137.1_49823001_1 - 0.0046 16.7 0.0 0.0086 15.9 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.19 001185137.1_49823001_1 - 0.066 12.5 0.0 0.15 11.3 0.0 1.5 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.6 001185137.1_49823001_1 - 0.18 11.5 0.1 0.38 10.4 0.1 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DMAP1 PF05499.10 001243640.1_49824001_1 - 3.2e-74 248.2 8.4 6e-74 247.3 8.4 1.5 1 0 0 1 1 1 1 DNA methyltransferase 1-associated protein 1 (DMAP1) SANT_DAMP1_like PF16282.3 001243640.1_49824001_1 - 7.5e-33 112.4 4.1 1.4e-32 111.6 4.1 1.4 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 DUF342 PF03961.11 001243640.1_49824001_1 - 0.36 9.3 2.6 0.65 8.4 2.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Use1 PF09753.7 001243640.1_49824001_1 - 3 7.3 9.8 1.6 8.2 5.5 2.1 2 0 0 2 2 2 0 Membrane fusion protein Use1 ig PF00047.23 001113218.1_49823001_2 - 9.1e-19 67.3 0.1 6.5e-10 38.9 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001113218.1_49823001_2 - 6.4e-16 58.3 0.1 6e-10 39.2 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001113218.1_49823001_2 - 1.9e-10 41.0 0.0 0.00011 22.6 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 001113218.1_49823001_2 - 1.7e-06 28.0 1.8 2 8.5 0.0 4.3 2 2 1 4 4 4 3 Immunoglobulin V-set domain EphA2_TM PF14575.4 001113218.1_49823001_2 - 0.17 12.6 0.0 0.5 11.1 0.0 1.8 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Sushi PF00084.18 214281.2_49829001_3 - 4.9e-163 529.7 144.3 1.2e-11 45.0 0.8 20.0 20 0 0 20 20 20 19 Sushi repeat (SCR repeat) UDPGT PF00201.16 001244124.1_49825001_3 - 1.5e-251 835.4 0.1 1.8e-251 835.1 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001244124.1_49825001_3 - 2.9e-05 24.0 0.0 4.7e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain p450 PF00067.20 001134824.1_49824001_2 - 3.8e-128 428.0 0.2 4.4e-128 427.8 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 POTRA_2 PF08479.9 001163404.1_49824001_2 - 0.18 11.5 0.0 0.27 10.9 0.0 1.2 1 0 0 1 1 1 0 POTRA domain, ShlB-type Arm PF00514.21 001163404.1_49824001_3 - 1.8e-87 284.9 5.1 5.2e-11 42.1 0.0 8.6 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.18 001163404.1_49824001_3 - 8e-31 106.1 5.4 8e-31 106.1 5.4 2.0 3 0 0 3 3 1 1 Importin beta binding domain Arm_3 PF16186.3 001163404.1_49824001_3 - 3.7e-25 87.1 2.9 8e-25 86.0 2.9 1.6 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_EZ PF13513.4 001163404.1_49824001_3 - 2.3e-20 72.5 0.7 1.8e-06 28.1 0.0 5.5 3 1 2 5 5 5 4 HEAT-like repeat HEAT_2 PF13646.4 001163404.1_49824001_3 - 2.2e-11 43.9 0.1 0.011 15.9 0.0 5.5 2 1 5 7 7 7 3 HEAT repeats HEAT PF02985.20 001163404.1_49824001_3 - 3.4e-09 36.0 0.2 0.1 12.8 0.0 6.0 6 0 0 6 6 6 2 HEAT repeat V-ATPase_H_C PF11698.6 001163404.1_49824001_3 - 3.5e-05 23.8 0.4 0.11 12.5 0.2 3.4 3 1 1 4 4 4 2 V-ATPase subunit H Arm_2 PF04826.11 001163404.1_49824001_3 - 0.00019 20.9 4.8 0.73 9.1 0.3 4.4 3 1 0 4 4 4 1 Armadillo-like Cnd1 PF12717.5 001163404.1_49824001_3 - 0.0004 20.3 0.1 0.061 13.2 0.0 3.7 2 1 2 4 4 4 1 non-SMC mitotic condensation complex subunit 1 SEN1_N PF12726.5 001163404.1_49824001_3 - 0.00086 17.5 0.1 5.2 5.0 0.0 3.9 4 0 0 4 4 4 1 SEN1 N terminal ECF-ribofla_trS PF07155.10 001163404.1_49824001_3 - 0.0087 15.9 0.8 0.017 15.0 0.8 1.4 1 0 0 1 1 1 1 ECF-type riboflavin transporter, S component UxaC PF02614.12 001163404.1_49824001_3 - 0.026 13.2 0.1 2.5 6.7 0.0 2.1 2 0 0 2 2 2 0 Glucuronate isomerase DUF3554 PF12074.6 001163404.1_49824001_3 - 0.079 12.1 0.0 0.14 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3554) ParcG PF10274.7 001163404.1_49824001_3 - 0.29 11.1 1.2 1.1 9.2 0.1 2.4 2 1 1 3 3 3 0 Parkin co-regulated protein zinc_ribbon_10 PF10058.7 001244263.1_49824001_1 - 3.5e-21 74.6 0.3 5.6e-21 73.9 0.3 1.3 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein DUF4153 PF13687.4 001244263.1_49824001_1 - 0.0011 18.5 0.2 0.002 17.7 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4153) DUF2207 PF09972.7 001244263.1_49824001_1 - 0.019 13.6 0.2 0.027 13.1 0.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Fip1 PF05182.11 001244263.1_49824001_2 - 0.087 12.2 0.2 0.2 11.1 0.2 1.6 1 0 0 1 1 1 0 Fip1 motif Trypsin PF00089.24 001143712.1_49822001_3 - 2.3e-62 210.5 0.0 2.7e-62 210.4 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001143712.1_49822001_3 - 1.6e-10 41.9 0.0 2.6e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S29 PF02907.13 001143712.1_49822001_3 - 0.00011 21.9 1.6 0.00017 21.2 1.2 1.5 1 1 0 1 1 1 1 Hepatitis C virus NS3 protease DUF1986 PF09342.9 001143712.1_49822001_3 - 0.00086 19.5 0.0 0.0029 17.9 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Peptidase_M28 PF04389.15 001243691.1_49824001_1 - 4.7e-21 75.3 0.0 9.3e-21 74.3 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.26 001243691.1_49824001_1 - 0.027 14.0 0.0 0.33 10.5 0.0 2.3 2 0 0 2 2 2 0 Peptidase family M20/M25/M40 Interferon PF00143.17 001130246.1_49822001_1 - 6.5e-63 211.6 0.2 7.3e-63 211.4 0.2 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain TPT PF03151.14 110356.1_32927120_2 - 0.011 15.0 0.8 0.017 14.3 0.8 1.2 1 0 0 1 1 1 0 Triose-phosphate Transporter family EamA PF00892.18 110356.1_32927120_2 - 1.1 9.4 9.9 0.36 10.9 6.5 1.9 2 0 0 2 2 2 0 EamA-like transporter family KRAB PF01352.25 037894.1_26223120_2 - 3.2e-25 87.4 0.2 6.1e-25 86.5 0.0 1.5 2 0 0 2 2 2 1 KRAB box Aldo_ket_red PF00248.19 001044618.1_49823001_2 - 3.9e-57 193.5 0.0 4.6e-57 193.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family V-set_2 PF15910.3 001287410.1_49823001_1 - 7.5e-13 48.4 1.5 1.1e-12 47.9 1.5 1.2 1 0 0 1 1 1 1 ICOS V-set domain V-set PF07686.15 001287410.1_49823001_1 - 1.9e-06 27.9 0.2 3.1e-06 27.2 0.2 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain DUF588 PF04535.10 001287410.1_49823001_1 - 0.0088 15.7 0.8 0.016 14.9 0.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF588) DUF2207 PF09972.7 001287410.1_49823001_1 - 0.074 11.7 0.0 0.1 11.2 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) APOBEC_N PF08210.9 001097446.1_49824001_1 - 6.2e-84 280.2 12.6 1.7e-46 158.3 3.0 2.1 2 0 0 2 2 2 2 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001097446.1_49824001_1 - 1.5e-61 204.1 3.5 6e-31 106.1 0.2 2.3 2 0 0 2 2 2 2 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 001097446.1_49824001_1 - 3.2e-07 30.0 0.6 0.0033 17.2 0.1 2.2 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region Pox_E10 PF04805.10 001097446.1_49824001_1 - 0.0052 16.5 2.4 0.58 9.9 0.1 2.6 2 0 0 2 2 2 2 E10-like protein conserved region Hairy_orange PF07527.11 001097446.1_49824001_1 - 0.029 14.4 0.6 1.6 8.9 0.0 2.6 2 0 0 2 2 2 0 Hairy Orange MafB19-deam PF14437.4 001097446.1_49824001_1 - 0.035 13.7 1.7 0.04 13.5 0.0 1.8 2 0 0 2 2 2 0 MafB19-like deaminase Tox-PL-2 PF15643.4 001097446.1_49824001_1 - 0.13 12.2 0.4 5.9 6.9 0.0 2.4 2 0 0 2 2 2 0 Papain fold toxin 2 V-set PF07686.15 001195347.1_49823001_1 - 1.9e-06 27.8 0.0 3.8e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001195347.1_49823001_1 - 0.017 15.6 0.0 1.3 9.5 0.0 2.9 2 2 0 2 2 2 0 Immunoglobulin domain ig PF00047.23 001195347.1_49823001_1 - 0.12 12.5 0.0 3 7.9 0.0 2.7 2 1 0 2 2 2 0 Immunoglobulin domain CSF-1 PF05337.9 001244523.1_49822001_2 - 1.4e-90 300.5 7.6 1.8e-90 300.2 7.6 1.1 1 0 0 1 1 1 1 Macrophage colony stimulating factor-1 (CSF-1) Interferon PF00143.17 001166319.1_49822001_1 - 3.1e-65 219.1 0.3 3.5e-65 218.9 0.3 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain Homeobox PF00046.27 001244338.1_49822001_2 - 4.9e-21 74.2 5.7 9e-21 73.3 5.7 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001244338.1_49822001_2 - 0.04 13.7 0.2 0.082 12.7 0.2 1.5 1 0 0 1 1 1 0 Homeobox KN domain COX5B PF01215.17 001244338.1_49822001_2 - 0.046 13.3 0.0 0.085 12.4 0.0 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Vb V-set PF07686.15 001256777.1_49822001_3 - 3.7e-09 36.6 0.1 5.9e-09 35.9 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001256777.1_49822001_3 - 0.014 15.8 0.0 0.047 14.2 0.0 1.9 1 1 0 1 1 1 0 Immunoglobulin domain ig PF00047.23 001256777.1_49822001_3 - 0.031 14.3 0.1 0.21 11.6 0.0 2.2 2 0 0 2 2 2 0 Immunoglobulin domain I-set PF07679.14 001256777.1_49822001_3 - 0.1 12.6 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain COesterase PF00135.26 001315766.1_49824001_3 - 9.9e-168 559.1 0.0 1.1e-167 558.9 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 001315766.1_49824001_3 - 9.1e-11 41.9 2.8 4.2e-10 39.7 2.8 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 001315766.1_49824001_3 - 0.003 16.9 0.3 0.0053 16.1 0.3 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.7 001315766.1_49824001_3 - 0.033 12.9 0.0 0.072 11.8 0.0 1.3 1 1 0 1 1 1 0 Steryl acetyl hydrolase Reprolysin PF01421.17 001098595.2_49825001_1 - 3.5e-62 209.7 0.4 7.9e-62 208.6 0.4 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.17 001098595.2_49825001_1 - 3.1e-21 76.0 0.0 5.2e-21 75.2 0.0 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_CR PF08516.10 001098595.2_49825001_1 - 8.2e-19 68.0 5.5 8.2e-19 68.0 5.5 3.7 3 1 0 3 3 3 1 ADAM cysteine-rich Disintegrin PF00200.21 001098595.2_49825001_1 - 1.4e-17 64.1 27.2 1.4e-17 64.1 27.2 3.9 4 0 0 4 4 4 1 Disintegrin Reprolysin_5 PF13688.4 001098595.2_49825001_1 - 5.6e-06 26.5 0.0 1.5e-05 25.1 0.0 1.8 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 001098595.2_49825001_1 - 7.3e-06 26.4 0.0 1.4e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.11 001098595.2_49825001_1 - 0.0015 18.7 9.5 0.0015 18.7 9.5 5.9 7 1 0 7 7 7 1 EGF-like domain CD225 PF04505.10 001201382.1_49821001_1 - 2.6e-32 110.6 2.5 4.6e-32 109.8 2.5 1.4 1 0 0 1 1 1 1 Interferon-induced transmembrane protein SdpI PF13630.4 001201382.1_49821001_1 - 0.17 11.9 2.8 0.28 11.2 2.7 1.4 1 1 0 1 1 1 0 SdpI/YhfL protein family PepSY_TM PF03929.14 001201382.1_49821001_1 - 0.21 10.8 2.5 0.41 9.9 2.5 1.4 1 0 0 1 1 1 0 PepSY-associated TM region ig PF00047.23 001146129.1_49821001_1 - 3.1e-09 36.7 0.2 4.1e-09 36.3 0.2 1.2 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 001146129.1_49821001_1 - 0.014 15.9 0.0 0.025 15.0 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.15 001146129.1_49821001_1 - 0.019 15.0 0.1 0.036 14.1 0.1 1.6 1 1 0 1 1 1 0 Immunoglobulin V-set domain I-set PF07679.14 001146129.1_49821001_1 - 0.095 12.7 0.0 0.2 11.6 0.0 1.6 1 1 0 1 1 1 0 Immunoglobulin I-set domain G-alpha PF00503.18 001123115.1_49823001_1 - 2.5e-125 418.2 1.6 2.9e-125 418.0 1.6 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 001123115.1_49823001_1 - 4.2e-18 65.3 0.1 3.6e-13 49.2 0.1 2.7 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001123115.1_49823001_1 - 2.1e-06 27.1 1.3 0.0067 15.7 0.8 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.11 001123115.1_49823001_1 - 7.4e-05 22.8 0.1 0.59 10.3 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 001123115.1_49823001_1 - 0.022 15.0 0.0 0.036 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Ras PF00071.20 001123115.1_49823001_1 - 0.042 13.3 1.4 3.2 7.2 0.7 2.4 2 0 0 2 2 2 0 Ras family TniB PF05621.9 001123115.1_49823001_1 - 0.087 11.9 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein AAA_29 PF13555.4 001123115.1_49823001_1 - 0.11 12.1 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SBF PF01758.14 001244463.1_49823001_3 - 2.4e-45 154.5 16.7 2.4e-45 154.5 16.7 1.8 2 0 0 2 2 2 1 Sodium Bile acid symporter family Toxin_16 PF07945.9 001244463.1_49823001_3 - 6.9 6.5 7.1 2.3 8.1 0.9 2.3 2 0 0 2 2 2 0 Janus-atracotoxin Calpain_inhib PF00748.17 214067.1_49825001_1 - 1.1e-109 362.3 132.0 3.5e-36 124.5 18.2 7.3 5 1 1 6 6 6 5 Calpain inhibitor Maf_N PF08383.9 214067.1_49825001_1 - 0.0043 16.7 0.4 1.7 8.3 0.1 2.7 2 0 0 2 2 2 2 Maf N-terminal region SCP2 PF02036.15 001168415.1_49824001_1 - 7e-28 97.0 0.5 1.4e-27 96.0 0.5 1.5 1 0 0 1 1 1 1 SCP-2 sterol transfer family Thiolase_N PF00108.21 001168415.1_49824001_1 - 1e-23 83.9 0.0 7.1e-23 81.1 0.0 2.3 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.16 001168415.1_49824001_1 - 1e-13 50.9 0.2 2.8e-12 46.2 0.1 3.0 2 1 0 2 2 2 1 Thiolase, C-terminal domain Alkyl_sulf_C PF14864.4 001168415.1_49824001_1 - 6.7e-06 26.3 0.0 1.2e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal ketoacyl-synt PF00109.24 001168415.1_49824001_1 - 5.5e-05 22.7 0.4 0.00016 21.2 0.4 1.7 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.8 001168415.1_49824001_1 - 9.7e-05 22.0 1.2 0.011 15.4 0.1 2.8 3 0 0 3 3 3 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III SCP2_2 PF13530.4 001168415.1_49824001_1 - 0.0016 18.3 0.0 0.0037 17.2 0.0 1.5 1 0 0 1 1 1 1 Sterol carrier protein domain Ketoacyl-synt_C PF02801.20 001168415.1_49824001_1 - 0.0019 18.0 0.1 0.15 11.9 0.0 2.8 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain SpoVAD PF07451.9 001168415.1_49824001_1 - 0.012 14.2 0.2 0.063 11.8 0.0 2.0 2 0 0 2 2 2 0 Stage V sporulation protein AD (SpoVAD) MHC_I PF00129.16 001246242.1_49823001_1 - 1.5e-85 285.2 0.5 2e-85 284.7 0.5 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001246242.1_49823001_1 - 5.6e-17 61.9 0.0 1.2e-16 60.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001246242.1_49823001_1 - 3.4e-14 52.3 6.4 3.8e-13 49.0 6.9 2.2 2 0 0 2 2 2 1 MHC_I C-terminus ig PF00047.23 001246242.1_49823001_1 - 0.0004 20.4 0.1 0.0015 18.6 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.10 001246242.1_49823001_1 - 0.0043 17.0 2.4 0.0046 16.9 0.3 2.0 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.4 001246242.1_49823001_1 - 0.046 13.9 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain DUF4448 PF14610.4 001246242.1_49823001_1 - 0.052 13.2 0.0 0.088 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF1822 PF08852.9 001246242.1_49823001_1 - 0.41 9.5 2.8 4.1 6.2 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1822) Interferon PF00143.17 001195375.1_49822001_1 - 1e-65 220.6 0.3 1.2e-65 220.5 0.3 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain C1-set PF07654.13 213828.1_49823001_1 - 7.4e-65 215.3 9.0 1.3e-28 99.1 0.0 4.0 4 0 0 4 4 4 3 Immunoglobulin C1-set domain C2-set_2 PF08205.10 213828.1_49823001_1 - 4.6e-18 65.0 0.6 6.1e-07 29.3 0.0 3.2 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 213828.1_49823001_1 - 1.1e-15 57.9 5.7 0.00012 22.5 0.0 4.7 4 1 0 4 4 4 4 Immunoglobulin domain V-set PF07686.15 213828.1_49823001_1 - 1.7e-14 53.7 1.8 8.6e-14 51.5 0.1 3.0 4 0 0 4 4 4 1 Immunoglobulin V-set domain ig PF00047.23 213828.1_49823001_1 - 1.3e-13 50.8 5.3 5e-05 23.3 0.0 5.1 4 2 0 4 4 4 3 Immunoglobulin domain I-set PF07679.14 213828.1_49823001_1 - 0.00015 21.7 0.6 1.5 8.8 0.0 3.9 4 1 0 4 4 4 2 Immunoglobulin I-set domain SSI PF00720.15 213828.1_49823001_3 - 0.18 11.6 2.7 0.17 11.8 0.4 2.0 2 0 0 2 2 2 0 Subtilisin inhibitor-like B12D PF06522.9 001205377.1_49822001_3 - 2.6e-29 100.7 0.0 4e-29 100.1 0.0 1.3 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit Glyco_transf_6 PF03414.11 213799.1_49823001_1 - 6.2e-160 531.1 0.0 7.4e-160 530.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 6 SNAP PF14938.4 038456.1_26224120_1 - 3e-109 364.7 20.6 3.6e-109 364.4 20.6 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.4 038456.1_26224120_1 - 1.9e-06 27.9 12.5 0.0036 17.4 0.9 3.8 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.4 038456.1_26224120_1 - 0.0034 17.2 5.2 1.2 9.2 0.0 4.6 4 1 1 5 5 5 2 Tetratricopeptide repeat NSF PF02071.18 038456.1_26224120_1 - 0.021 15.3 34.4 9.7 7.4 1.3 8.1 7 1 1 8 8 8 0 Aromatic-di-Alanine (AdAR) repeat TPR_1 PF00515.26 038456.1_26224120_1 - 0.031 14.0 8.5 2.2 8.1 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Spatacsin_C PF14649.4 038456.1_26224120_1 - 0.032 13.2 6.9 0.92 8.5 1.5 2.4 1 1 1 2 2 2 0 Spatacsin C-terminus TPR_6 PF13174.4 038456.1_26224120_1 - 0.62 10.7 10.2 12 6.6 0.2 5.2 5 2 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.4 038456.1_26224120_1 - 1.1 9.6 17.2 3 8.1 0.0 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.15 038456.1_26224120_1 - 1.6 8.9 16.2 6.6 7.0 0.0 5.6 4 1 1 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.4 038456.1_26224120_1 - 2.8 7.8 7.6 14 5.5 0.0 4.7 4 1 2 6 6 6 0 Tetratricopeptide repeat TPR_11 PF13414.4 038456.1_26224120_1 - 7.4 6.2 7.3 83 2.9 0.2 4.0 4 0 0 4 4 4 0 TPR repeat zf-C3HC4_3 PF13920.4 037714.1_26228120_2 - 3.5e-12 45.8 12.5 8.6e-12 44.6 12.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rad51 PF08423.9 037714.1_26228120_2 - 0.00013 21.2 0.1 0.0002 20.6 0.1 1.1 1 0 0 1 1 1 1 Rad51 Prok-RING_4 PF14447.4 037714.1_26228120_2 - 0.00081 19.1 12.2 0.0019 17.9 12.2 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 037714.1_26228120_2 - 0.011 15.5 12.4 0.026 14.3 12.4 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.4 037714.1_26228120_2 - 0.012 15.3 14.4 0.029 14.1 14.4 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DnaB_C PF03796.13 037714.1_26228120_2 - 0.04 13.1 0.2 0.059 12.5 0.2 1.1 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_25 PF13481.4 037714.1_26228120_2 - 0.063 12.7 0.3 0.094 12.1 0.3 1.2 1 0 0 1 1 1 0 AAA domain CbiG_N PF11760.6 037714.1_26228120_2 - 0.22 11.4 0.4 0.4 10.6 0.4 1.3 1 0 0 1 1 1 0 Cobalamin synthesis G N-terminal zf-C4 PF00105.16 001170521.1_49823001_1 - 7.1e-31 106.4 12.3 1e-30 105.9 12.3 1.2 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001170521.1_49823001_1 - 6.8e-30 104.1 0.0 9.4e-30 103.6 0.0 1.1 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Rogdi_lz PF10259.7 046480.1_26224120_1 - 7.8e-30 104.1 0.0 9.6e-30 103.8 0.0 1.1 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein Rogdi_lz PF10259.7 046480.1_26224120_2 - 0.042 13.2 0.0 0.058 12.7 0.0 1.1 1 0 0 1 1 1 0 Rogdi leucine zipper containing protein zf-CpG_bind_C PF12269.6 033924.1_26224120_1 - 3.1e-05 23.8 0.1 4.5e-05 23.2 0.1 1.1 1 0 0 1 1 1 1 CpG binding protein zinc finger C terminal domain zf-CpG_bind_C PF12269.6 033924.1_26224120_2 - 2.3e-23 83.1 6.7 5.3e-14 52.4 1.9 2.7 3 0 0 3 3 3 2 CpG binding protein zinc finger C terminal domain Reprolysin PF01421.17 024107.2_26226120_3 - 1.4e-64 217.6 0.4 2.9e-64 216.5 0.4 1.6 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 024107.2_26226120_3 - 5.9e-21 74.9 8.0 5.9e-21 74.9 8.0 3.6 3 1 0 3 3 3 1 ADAM cysteine-rich Pep_M12B_propep PF01562.17 024107.2_26226120_3 - 1e-18 67.8 0.1 1.8e-18 67.0 0.1 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide Disintegrin PF00200.21 024107.2_26226120_3 - 4.4e-13 49.7 22.5 4.4e-13 49.7 22.5 4.7 4 0 0 4 4 4 2 Disintegrin Reprolysin_5 PF13688.4 024107.2_26226120_3 - 8.4e-07 29.2 0.2 3.5e-06 27.2 0.2 2.1 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 024107.2_26226120_3 - 6.4e-05 23.3 0.1 0.00033 21.0 0.0 2.1 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Ly49 PF08391.8 028045.1_26225120_1 - 3.9e-47 159.4 8.6 7.2e-47 158.5 8.6 1.5 1 0 0 1 1 1 1 Ly49-like protein, N-terminal region Lectin_C PF00059.19 028045.1_26225120_2 - 1.7e-07 31.8 0.4 2.8e-07 31.1 0.4 1.3 1 0 0 1 1 1 1 Lectin C-type domain Radial_spoke_3 PF06098.9 001168984.1_40423001_1 - 1.4e-129 431.3 8.1 1.4e-129 431.3 8.1 1.7 2 0 0 2 2 2 1 Radial spoke protein 3 MFAP1 PF06991.9 001168971.1_40423001_1 - 3.6e-78 262.2 29.4 3.6e-78 262.2 29.4 2.2 2 0 0 2 2 2 2 Microfibril-associated/Pre-mRNA processing TNF PF00229.16 001328322.1_39722001_1 - 1.2e-23 83.3 0.7 1.7e-23 82.8 0.7 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family MFAP1 PF06991.9 001171317.1_37923001_1 - 2.6e-78 262.7 30.1 2.6e-78 262.7 30.1 2.2 2 0 0 2 2 2 2 Microfibril-associated/Pre-mRNA processing Complex1_LYR PF05347.13 028493.1_26229120_2 - 4.9e-13 48.8 0.6 1.1e-12 47.7 0.6 1.6 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.4 028493.1_26229120_2 - 0.0089 16.6 0.2 0.024 15.3 0.2 1.7 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.4 028493.1_26229120_2 - 0.022 15.2 0.2 0.038 14.4 0.2 1.3 1 0 0 1 1 1 0 Complex1_LYR-like Seipin PF06775.12 037946.1_26229120_1 - 4.7e-58 196.4 0.9 7.8e-58 195.7 0.9 1.3 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) AAA_33 PF13671.4 037946.1_26229120_1 - 8.4e-24 84.2 0.0 1.9e-23 83.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain SPRY PF00622.26 037946.1_26229120_1 - 9.7e-16 57.8 0.1 2.8e-15 56.4 0.1 1.8 1 0 0 1 1 1 1 SPRY domain SAP PF02037.25 037946.1_26229120_1 - 3.1e-08 33.0 3.0 6.7e-08 32.0 3.0 1.6 1 0 0 1 1 1 1 SAP domain Zeta_toxin PF06414.10 037946.1_26229120_1 - 0.00014 21.1 0.0 0.00025 20.2 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.4 037946.1_26229120_1 - 0.00097 19.5 0.0 0.0026 18.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.8 037946.1_26229120_1 - 0.0067 15.8 0.1 0.011 15.0 0.1 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_17 PF13207.4 037946.1_26229120_1 - 0.013 15.8 0.3 0.067 13.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.20 037946.1_26229120_1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain PRELI PF04707.12 037930.1_26222120_2 - 7.9e-22 77.6 0.2 1.7e-21 76.5 0.0 1.6 2 0 0 2 2 2 1 PRELI-like family ATP-synt_Eps PF04627.11 037930.1_26222120_2 - 2.3e-13 49.8 1.2 4.4e-13 48.9 1.2 1.4 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain TraB PF01963.15 001277053.1_26224001_3 - 3.7e-62 210.5 0.0 5.5e-62 209.9 0.0 1.3 1 0 0 1 1 1 1 TraB family RhoGAP PF00620.25 045675.1_26227120_1 - 2.9e-16 59.5 0.0 6e-16 58.5 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain ATG16 PF08614.9 045675.1_26227120_1 - 0.00048 20.2 7.2 0.00086 19.4 7.2 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Tropomyosin_1 PF12718.5 045675.1_26227120_1 - 0.0028 17.7 8.2 0.0047 16.9 8.2 1.2 1 0 0 1 1 1 1 Tropomyosin like IncA PF04156.12 045675.1_26227120_1 - 0.009 15.7 2.1 0.017 14.8 2.1 1.4 1 0 0 1 1 1 1 IncA protein HAUS-augmin3 PF14932.4 045675.1_26227120_1 - 0.09 12.2 4.9 0.15 11.4 4.9 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 CALCOCO1 PF07888.9 045675.1_26227120_1 - 0.12 10.8 6.5 0.18 10.2 6.5 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like ADIP PF11559.6 045675.1_26227120_1 - 0.14 12.1 6.7 0.22 11.4 6.7 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding APG6 PF04111.10 045675.1_26227120_1 - 0.26 10.5 4.7 0.44 9.7 4.7 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 TPR_MLP1_2 PF07926.10 045675.1_26227120_1 - 1.5 8.8 10.8 2.8 7.9 10.8 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein CENP-Q PF13094.4 045675.1_26227120_1 - 6.4 6.8 10.3 12 5.9 10.3 1.4 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit PH PF00169.27 045675.1_26227120_2 - 2.9e-22 79.1 0.0 5.4e-22 78.2 0.0 1.4 1 0 0 1 1 1 1 PH domain RhoGAP PF00620.25 045675.1_26227120_2 - 8.9e-21 74.2 0.0 1.3e-20 73.6 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain PH_11 PF15413.4 045675.1_26227120_2 - 4.5e-06 26.9 0.2 0.00024 21.4 0.3 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.4 045675.1_26227120_2 - 0.0015 18.6 0.1 0.12 12.6 0.1 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.4 045675.1_26227120_2 - 0.018 15.0 0.1 0.047 13.7 0.0 1.6 2 0 0 2 2 2 0 PH domain TPR_17 PF13431.4 051965.1_26225120_1 - 0.00094 19.3 0.4 0.14 12.5 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.15 051965.1_26225120_1 - 0.02 14.9 0.5 0.02 14.9 0.5 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.5 051965.1_26225120_1 - 0.051 13.7 0.7 0.1 12.7 0.7 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.4 051965.1_26225120_1 - 0.076 13.1 1.8 0.12 12.6 0.5 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TetR_N PF00440.21 051965.1_26225120_1 - 0.18 11.5 0.0 0.33 10.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family TPR_1 PF00515.26 051965.1_26225120_1 - 0.25 11.1 3.4 0.24 11.1 1.3 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat MRP-S31 PF15433.4 051965.1_26225120_2 - 0.17 11.4 0.1 0.24 10.9 0.1 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 Transferrin PF00405.15 001081992.1_37925001_3 - 2.2e-238 789.5 0.3 1.1e-139 465.0 0.1 2.0 2 0 0 2 2 2 2 Transferrin Phosphonate-bd PF12974.5 001081992.1_37925001_3 - 1.3e-14 54.3 0.0 6.3e-06 25.8 0.0 3.1 3 1 0 3 3 3 2 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.18 001081992.1_37925001_3 - 0.0012 18.2 0.1 1.3 8.3 0.0 2.3 2 0 0 2 2 2 2 Bacterial extracellular solute-binding proteins, family 3 MG1 PF11974.6 001081992.1_37925001_3 - 0.08 12.8 0.0 3.4 7.6 0.0 3.0 3 0 0 3 3 3 0 Alpha-2-macroglobulin MG1 domain UQ_con PF00179.24 001078674.1_49821001_1 - 4e-54 181.9 0.0 4.5e-54 181.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.20 001078674.1_49821001_1 - 0.0015 18.7 0.1 0.0023 18.1 0.0 1.4 2 0 0 2 2 2 1 RWD domain Prok-E2_B PF14461.4 001078674.1_49821001_1 - 0.0071 15.9 0.0 0.0083 15.7 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.11 001078674.1_49821001_1 - 0.096 12.4 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 UEV domain TPMT PF05724.9 001082684.1_37922001_1 - 5.9e-82 274.4 0.0 6.7e-82 274.2 0.0 1.0 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_25 PF13649.4 001082684.1_37922001_1 - 0.00024 21.6 0.0 0.0032 18.0 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001082684.1_37922001_1 - 0.0026 18.2 0.0 0.0098 16.4 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Pkinase PF00069.23 001025224.2_49824001_1 - 2.5e-68 230.2 0.0 3.6e-68 229.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001025224.2_49824001_1 - 1.8e-29 102.7 0.0 2.8e-29 102.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 001025224.2_49824001_1 - 0.00035 20.5 0.1 0.0034 17.2 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.12 001025224.2_49824001_1 - 0.0053 16.0 0.0 0.0098 15.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 001025224.2_49824001_1 - 0.0068 15.6 0.0 0.011 14.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Cytochrom_B558a PF05038.11 214267.1_49822001_1 - 6.8e-98 325.6 0.7 8e-98 325.3 0.7 1.1 1 0 0 1 1 1 1 Cytochrome Cytochrome b558 alpha-subunit Cg6151-P PF10233.7 214267.1_49822001_1 - 0.0065 16.6 2.5 0.031 14.4 2.5 1.9 1 1 0 1 1 1 1 Uncharacterized conserved protein CG6151-P IL6Ra-bind PF09240.8 214083.2_49823001_1 - 1.6e-11 44.3 0.7 2.6e-11 43.7 0.7 1.3 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding fn3 PF00041.19 214083.2_49823001_1 - 2e-07 31.2 0.5 1.4e-06 28.5 0.0 2.3 2 0 0 2 2 2 1 Fibronectin type III domain EpoR_lig-bind PF09067.8 214083.2_49823001_1 - 0.00015 21.8 0.6 0.00028 20.9 0.6 1.3 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding ZFYVE21_C PF16696.3 001108725.1_45722001_2 - 2.1e-47 159.9 0.0 3.7e-47 159.1 0.0 1.3 1 0 0 1 1 1 1 Zinc finger FYVE domain-containing protein 21 C-terminus FYVE PF01363.19 001108725.1_45722001_2 - 3.7e-14 52.5 22.5 3.7e-14 52.5 22.5 2.0 2 0 0 2 2 2 1 FYVE zinc finger SHIPPO-rpt PF07004.10 001100993.1_45725001_2 - 1.4e-17 63.5 40.6 0.59 11.0 0.0 12.1 12 0 0 12 12 12 10 Sperm-tail PG-rich repeat S_100 PF01023.17 001044557.1_49821001_2 - 1.3e-16 59.9 0.2 2.3e-16 59.1 0.2 1.4 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 001044557.1_49821001_2 - 4.5e-08 33.3 0.3 5.9e-08 33.0 0.3 1.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 001044557.1_49821001_2 - 8.8e-05 21.7 0.5 0.0013 18.0 0.1 2.3 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 001044557.1_49821001_2 - 0.028 14.2 0.2 8.9 6.4 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain EF-hand_8 PF13833.4 001044557.1_49821001_2 - 0.077 12.7 0.2 0.11 12.1 0.2 1.2 1 0 0 1 1 1 0 EF-hand domain pair Osteopontin PF00865.16 001082194.1_37923001_1 - 3.3e-138 459.9 61.0 3.8e-138 459.7 61.0 1.0 1 0 0 1 1 1 1 Osteopontin Acetyltransf_1 PF00583.23 016347.2_26222001_3 - 1.2e-18 67.3 0.0 1.8e-18 66.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.5 016347.2_26222001_3 - 3.9e-13 49.5 0.0 6.5e-13 48.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.5 016347.2_26222001_3 - 4.2e-13 49.2 0.0 6.5e-13 48.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.4 016347.2_26222001_3 - 4.7e-08 32.9 0.0 8.4e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.5 016347.2_26222001_3 - 3.3e-07 30.3 0.0 7.4e-06 25.9 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.8 016347.2_26222001_3 - 9.7e-06 25.3 0.0 1.8e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.5 016347.2_26222001_3 - 1.2e-05 25.5 0.0 1.8e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.5 016347.2_26222001_3 - 5.3e-05 23.8 0.0 8.8e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.4 016347.2_26222001_3 - 0.021 14.4 0.0 0.034 13.7 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain EMP24_GP25L PF01105.22 001082408.1_37922001_1 - 2.4e-48 164.4 0.1 2.7e-48 164.2 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Peptidase_C48 PF02902.17 001105888.1_45729001_1 - 5.3e-33 114.5 4.2 9.6e-33 113.7 4.2 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain SSF PF00474.15 214410.1_49827001_2 - 6.1e-44 150.4 21.3 8e-44 150.0 21.3 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family NdhL PF10716.7 214410.1_49827001_2 - 0.29 11.0 1.9 0.46 10.3 1.1 1.7 1 1 0 1 1 1 0 NADH dehydrogenase transmembrane subunit Pribosyltran PF00156.25 001110817.1_39723001_1 - 1.6e-22 79.6 0.0 2.3e-22 79.1 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain TIP39 PF14980.4 001109144.1_45721001_2 - 6.5e-29 99.4 6.0 1.1e-28 98.7 6.0 1.4 1 0 0 1 1 1 1 TIP39 peptide MARVEL PF01284.21 001082097.1_37922001_3 - 8.2e-12 45.2 14.0 1.6e-11 44.3 14.0 1.5 1 1 0 1 1 1 1 Membrane-associating domain AC_N PF16214.3 001082097.1_37922001_3 - 0.54 9.2 3.3 0.73 8.8 3.3 1.1 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF2070 PF09843.7 001082097.1_37922001_3 - 0.63 8.1 4.5 0.79 7.8 4.5 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) ANF_receptor PF01094.26 001082735.1_37927001_2 - 9.5e-104 347.1 0.0 1.2e-103 346.8 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 001082735.1_37927001_2 - 8.4e-58 195.8 7.3 1.3e-57 195.2 7.3 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 001082735.1_37927001_2 - 1.6e-13 50.2 11.9 5e-13 48.7 11.9 1.9 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001082735.1_37927001_2 - 1.3e-08 34.8 0.5 4.1e-07 29.9 0.1 2.2 2 0 0 2 2 2 1 Periplasmic binding protein Troponin PF00992.18 001032359.1_49822001_1 - 1.2e-46 158.3 7.6 1.9e-46 157.5 7.6 1.4 1 0 0 1 1 1 1 Troponin Tup_N PF08581.8 001032359.1_49822001_1 - 0.00092 19.3 1.1 0.00092 19.3 1.1 2.0 2 0 0 2 2 2 1 Tup N-terminal Transposase_22 PF02994.12 001032359.1_49822001_1 - 0.0059 15.4 1.5 0.0059 15.4 1.5 1.7 1 1 1 2 2 2 1 L1 transposable element DUF2408 PF10303.7 001032359.1_49822001_1 - 0.0065 16.9 4.7 0.014 15.9 4.7 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF2408) DUF919 PF06034.9 001032359.1_49822001_1 - 0.014 15.0 1.1 0.014 15.0 1.1 2.3 2 1 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) BST2 PF16716.3 001032359.1_49822001_1 - 9.9 6.7 9.9 2.9 8.4 1.9 2.6 3 0 0 3 3 3 0 Bone marrow stromal antigen 2 Serpin PF00079.18 001111256.2_49824001_1 - 4.5e-127 424.3 0.1 5.2e-127 424.1 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) NNMT_PNMT_TEMT PF01234.15 001082043.1_37924001_1 - 2.5e-105 351.1 0.0 3.3e-105 350.8 0.0 1.1 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_23 PF13489.4 001082043.1_37924001_1 - 0.002 18.0 0.0 0.0047 16.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001082043.1_37924001_1 - 0.12 13.0 0.0 0.26 11.9 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Neurexophilin PF06312.10 001101712.1_37925001_2 - 5.6e-18 65.0 0.0 1e-17 64.2 0.0 1.4 1 0 0 1 1 1 1 Neurexophilin Filamin PF00630.17 001101712.1_37925001_2 - 0.0012 19.5 0.0 0.0037 17.9 0.0 1.7 2 0 0 2 2 2 1 Filamin/ABP280 repeat GST_N PF02798.18 001078684.1_49822001_3 - 4.4e-22 78.1 0.0 1.1e-21 76.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.4 001078684.1_49822001_3 - 5.6e-17 61.6 0.0 1e-16 60.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 001078684.1_49822001_3 - 4.3e-16 58.8 0.0 7.9e-16 57.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.2 001078684.1_49822001_3 - 0.00013 21.6 0.5 0.00034 20.2 0.2 1.9 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 001078684.1_49822001_3 - 0.00068 19.4 0.0 0.0016 18.2 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 001078684.1_49822001_3 - 0.0015 18.7 0.0 0.0033 17.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain 7tm_1 PF00001.19 001082347.1_37923001_3 - 1e-47 162.5 3.8 1.5e-47 161.9 3.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 001082347.1_37923001_3 - 0.016 14.4 0.2 0.061 12.5 0.0 1.9 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.7 001082347.1_37923001_3 - 0.016 14.4 0.0 0.025 13.8 0.0 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv Cys_knot PF00007.20 001112656.1_40422001_3 - 4.4e-34 116.8 7.1 5.6e-34 116.5 7.1 1.1 1 0 0 1 1 1 1 Cystine-knot domain Na_H_Exchanger PF00999.19 001082697.1_37926001_2 - 1.9e-85 286.8 52.9 2.4e-85 286.5 52.9 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family NEXCaM_BD PF16644.3 001082697.1_37926001_2 - 0.051 13.7 4.6 0.086 13.0 4.6 1.3 1 0 0 1 1 1 0 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin Cys_knot PF00007.20 001082171.2_37924001_2 - 1.4e-33 115.2 15.7 2.2e-33 114.5 15.7 1.3 1 0 0 1 1 1 1 Cystine-knot domain Glyco_transf_11 PF01531.14 001082402.1_37924001_3 - 1.3e-136 454.5 0.0 1.5e-136 454.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl transferase family 11 O-FucT PF10250.7 001082402.1_37924001_3 - 0.028 14.0 0.9 0.27 10.8 0.8 1.9 1 1 1 2 2 2 0 GDP-fucose protein O-fucosyltransferase ART PF01129.16 001082670.1_37923001_1 - 4e-93 310.6 0.0 5.1e-93 310.3 0.0 1.1 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase RRM_DME PF15628.4 001082670.1_37923001_1 - 0.17 11.9 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 RRM in Demeter ADPrib_exo_Tox PF03496.12 001082670.1_37923001_1 - 0.25 10.5 0.0 0.42 9.8 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosyltransferase exoenzyme Parathyroid PF01279.15 001082653.1_37922001_1 - 2e-33 115.1 0.7 4.2e-33 114.1 0.7 1.5 1 0 0 1 1 1 1 Parathyroid hormone family E1_DerP2_DerF2 PF02221.13 001097415.1_49822001_3 - 3.7e-05 24.0 0.0 5.1e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 ML domain Homeobox PF00046.27 214121.1_49822001_1 - 1.9e-20 72.3 7.2 1.9e-20 72.3 7.2 1.7 2 0 0 2 2 2 1 Homeobox domain ANP PF00212.16 001082262.1_37922001_3 - 1e-10 41.4 2.8 1.7e-10 40.7 2.8 1.4 1 0 0 1 1 1 1 Atrial natriuretic peptide Na_K-ATPase PF00287.16 001082289.1_37923001_3 - 2e-105 351.9 1.0 2.3e-105 351.7 1.0 1.0 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain Ras PF00071.20 214296.1_49822001_1 - 3.1e-43 147.0 0.0 4.2e-43 146.6 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 214296.1_49822001_1 - 6.7e-19 68.2 0.0 1.2e-18 67.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 214296.1_49822001_1 - 1.6e-06 27.6 0.0 2.4e-06 27.0 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family GNT-I PF03071.13 001082745.1_37925001_2 - 4.5e-206 684.6 0.0 5.2e-206 684.4 0.0 1.0 1 0 0 1 1 1 1 GNT-I family FAM72 PF14976.4 001081451.1_45721001_1 - 5.5e-80 266.4 6.4 6.2e-80 266.3 6.4 1.0 1 0 0 1 1 1 1 FAM72 protein Peptidase_M1 PF01433.18 001082326.1_37927001_1 - 1.6e-141 472.0 0.0 4.4e-141 470.5 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M1 ERAP1_C PF11838.6 001082326.1_37927001_1 - 4e-84 282.7 4.1 4e-84 282.7 4.1 1.7 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Aminopep PF10023.7 001082326.1_37927001_1 - 0.0075 15.5 0.0 0.015 14.5 0.0 1.4 1 0 0 1 1 1 1 Putative aminopeptidase Lipase PF00151.17 001082106.1_37924001_2 - 1.6e-82 277.4 0.0 2.3e-82 276.9 0.0 1.1 1 0 0 1 1 1 1 Lipase Abhydrolase_2 PF02230.14 001082106.1_37924001_2 - 0.017 14.8 0.0 0.029 14.0 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Cys_knot PF00007.20 001082695.1_37922001_2 - 4.4e-32 110.4 2.1 5.2e-32 110.1 2.1 1.0 1 0 0 1 1 1 1 Cystine-knot domain Hormone_6 PF00236.16 001082724.1_37922001_1 - 1e-52 176.0 11.3 1.3e-52 175.6 11.3 1.2 1 0 0 1 1 1 1 Glycoprotein hormone DUF1218 PF06749.10 001082724.1_37922001_1 - 1.3 9.5 7.3 0.47 10.9 4.4 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1218) IL1 PF00340.17 001082770.1_37924001_3 - 4.5e-37 126.3 0.0 6.4e-37 125.8 0.0 1.2 1 0 0 1 1 1 1 Interleukin-1 / 18 BRICHOS PF04089.12 001082040.1_37923001_2 - 1.9e-17 63.0 0.0 3.1e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 BRICHOS domain 7tm_1 PF00001.19 001082380.1_37923001_1 - 3.8e-78 262.3 3.8 4.7e-78 262.0 3.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001082380.1_37923001_1 - 3.7e-17 62.4 3.8 6e-17 61.7 3.8 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001082380.1_37923001_1 - 1.3e-05 24.9 5.0 7.3e-05 22.5 2.8 2.2 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001082380.1_37923001_1 - 0.00014 21.1 7.9 0.00033 19.9 7.9 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx MIF4G PF02854.17 201354.2_32929001_2 - 4.3e-27 95.0 4.8 6.1e-27 94.5 4.8 1.2 1 0 0 1 1 1 1 MIF4G domain Spp-24 PF07448.9 213780.2_49822001_2 - 2.1e-40 136.5 0.9 4.2e-40 135.6 0.9 1.5 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Cathelicidins PF00666.15 213780.2_49822001_2 - 4.9e-07 29.9 0.0 7.5e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Cathelicidin Motilin_ghrelin PF04644.10 001101699.1_37922001_1 - 9.4e-17 60.4 0.6 1.7e-16 59.6 0.6 1.5 1 0 0 1 1 1 1 Motilin/ghrelin Motilin_assoc PF04643.10 001101699.1_37922001_1 - 1e-07 31.5 0.0 1.8e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Motilin/ghrelin-associated peptide Thymidylate_kin PF02223.15 020557.4_32927001_3 - 7e-16 58.3 0.0 1.4e-15 57.3 0.0 1.5 1 1 0 1 1 1 1 Thymidylate kinase AAA_18 PF13238.4 020557.4_32927001_3 - 2.4e-05 24.7 0.2 0.00025 21.4 0.2 2.1 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.4 020557.4_32927001_3 - 0.00024 21.1 0.1 0.0011 19.0 0.1 2.0 1 1 0 1 1 1 1 AAA domain dNK PF01712.17 020557.4_32927001_3 - 0.012 15.3 0.0 0.026 14.3 0.0 1.5 1 1 0 1 1 1 0 Deoxynucleoside kinase CNTF PF01110.15 001082283.1_37922001_1 - 1.2e-103 344.4 0.0 1.4e-103 344.2 0.0 1.0 1 0 0 1 1 1 1 Ciliary neurotrophic factor 7tm_1 PF00001.19 001082324.1_37925001_2 - 2.7e-49 167.7 22.5 4.3e-49 167.0 22.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001082324.1_37925001_2 - 4.6e-07 29.3 21.6 7.8e-07 28.6 21.6 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx SPC12 PF06645.11 001082324.1_37925001_2 - 0.47 10.5 5.5 2.8 8.0 5.5 2.4 1 0 0 1 1 1 0 Microsomal signal peptidase 12 kDa subunit (SPC12) IL15 PF02372.13 001082216.2_37922001_2 - 6.6e-58 194.4 4.3 6.6e-58 194.4 4.3 1.6 2 0 0 2 2 2 1 Interleukin 15 Arylesterase PF01731.18 001082078.2_37923001_3 - 7.4e-37 125.3 0.9 1.4e-36 124.4 0.9 1.5 1 0 0 1 1 1 1 Arylesterase SGL PF08450.10 001082078.2_37923001_3 - 3.1e-06 26.8 0.0 1.4e-05 24.6 0.0 1.8 1 1 0 2 2 2 1 SMP-30/Gluconolaconase/LRE-like region Str_synth PF03088.14 001082078.2_37923001_3 - 3.8e-05 23.6 0.0 0.00013 21.8 0.0 2.0 1 0 0 1 1 1 1 Strictosidine synthase Dysbindin PF04440.14 001243672.1_49823001_1 - 1.2e-27 96.7 0.1 2e-27 96.0 0.1 1.3 1 0 0 1 1 1 1 Dysbindin (Dystrobrevin binding protein 1) SYS1 PF09801.7 001243672.1_49823001_3 - 7e-15 55.3 0.1 9.5e-15 54.9 0.1 1.2 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network UDPGT PF00201.16 001315662.1_49824001_2 - 7.4e-118 394.3 0.0 8.7e-118 394.1 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001315662.1_49824001_2 - 2.6e-06 27.4 0.0 4.7e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_28 PF03033.18 001315662.1_49824001_2 - 0.097 12.6 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain CAP_N PF01213.17 001266532.1_29626001_2 - 5.3e-118 394.0 0.0 7e-118 393.6 0.0 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.9 001266532.1_29626001_2 - 4.7e-64 214.6 1.6 6.5e-64 214.2 1.6 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.10 001266532.1_29626001_2 - 0.001 18.6 2.1 0.0025 17.4 2.1 1.7 1 0 0 1 1 1 1 Tubulin binding cofactor C PRIMA1 PF16101.3 001266532.1_29626001_2 - 2.3 8.1 8.9 5.3 7.0 8.9 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Tet_JBP PF12851.5 001315772.1_49829001_1 - 2.2e-124 415.0 0.0 2.2e-124 415.0 0.0 1.9 2 0 0 2 2 2 1 Oxygenase domain of the 2OGFeDO superfamily zf-CXXC PF02008.18 001315772.1_49829001_1 - 1.7e-08 34.2 24.2 5.1e-08 32.7 24.2 1.9 1 0 0 1 1 1 1 CXXC zinc finger domain SET PF00856.26 001160089.1_49824001_3 - 1.4e-12 48.2 0.1 3e-12 47.1 0.1 1.6 1 0 0 1 1 1 1 SET domain zf-MYND PF01753.16 001160089.1_49824001_3 - 2.9e-08 33.5 18.9 2.9e-08 33.5 18.9 2.6 2 1 0 2 2 2 1 MYND finger TPR_12 PF13424.4 001160089.1_49824001_3 - 0.045 13.9 0.0 0.47 10.7 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Smg4_UPF3 PF03467.13 001266737.1_29625001_3 - 6.2e-55 185.8 5.1 6.2e-55 185.8 5.1 3.8 1 1 2 3 3 3 1 Smg-4/UPF3 family RRM_1 PF00076.20 001266737.1_29625001_3 - 0.016 14.9 0.0 0.037 13.7 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LRR_6 PF13516.4 001315695.1_49826001_1 - 6.7e-14 50.6 4.0 0.021 14.7 0.1 5.1 4 1 0 4 4 4 4 Leucine Rich repeat LRR_4 PF12799.5 001315695.1_49826001_1 - 9.1e-07 28.9 3.1 0.0033 17.6 2.0 3.7 1 1 4 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001315695.1_49826001_1 - 1.1e-05 25.0 3.7 0.014 15.0 0.1 3.6 2 1 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.31 001315695.1_49826001_1 - 0.0012 18.9 1.0 23 5.8 0.0 4.9 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_9 PF14580.4 001315695.1_49826001_1 - 0.014 14.8 0.0 0.031 13.7 0.0 1.5 1 0 0 1 1 1 0 Leucine-rich repeat PAP_assoc PF03828.17 001317082.1_49825001_1 - 3.3e-06 27.1 0.6 1.3e-05 25.2 0.6 2.0 1 1 0 1 1 1 1 Cid1 family poly A polymerase tRNA_NucTransf2 PF09249.9 001317082.1_49825001_1 - 0.11 12.6 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 tRNA nucleotidyltransferase, second domain CAP_N PF01213.17 001246593.1_39724001_2 - 2.7e-116 388.3 0.1 4.3e-116 387.7 0.1 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.9 001246593.1_39724001_2 - 1.2e-64 216.5 6.4 1.9e-64 215.9 6.4 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.10 001246593.1_39724001_2 - 0.0039 16.8 2.6 0.0071 15.9 2.6 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C Spc29 PF17082.3 001246593.1_39724001_2 - 0.023 14.4 0.0 0.07 12.8 0.0 1.7 1 0 0 1 1 1 0 Spindle Pole Component 29 WH2 PF02205.18 001246593.1_39724001_2 - 0.034 13.9 0.0 0.076 12.7 0.0 1.6 1 0 0 1 1 1 0 WH2 motif AKNA PF12443.6 001246593.1_39724001_2 - 0.084 13.4 0.0 0.19 12.3 0.0 1.6 1 0 0 1 1 1 0 AT-hook-containing transcription factor RRM_1 PF00076.20 001077228.1_49822001_1 - 3.9e-26 90.5 0.3 4.5e-14 51.9 0.0 2.6 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 001077228.1_49822001_1 - 6.7e-08 32.0 0.1 0.0038 16.7 0.2 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001077228.1_49822001_1 - 2e-07 30.6 0.0 0.0031 17.2 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif DUF1027 PF06265.9 001077228.1_49822001_1 - 0.079 12.8 0.5 0.53 10.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1027) 7tm_1 PF00001.19 001128487.1_49824001_3 - 3.5e-35 121.4 12.7 5.1e-35 120.9 12.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001128487.1_49824001_3 - 2.3e-05 24.2 9.6 0.0003 20.5 7.0 2.1 2 0 0 2 2 2 2 Olfactory receptor DUF3139 PF11337.6 001128487.1_49824001_3 - 0.17 12.3 5.0 0.15 12.5 0.9 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3139) Shisa PF13908.4 001128487.1_49824001_3 - 9.3 6.3 7.7 1.4 9.0 0.1 2.7 3 0 0 3 3 3 0 Wnt and FGF inhibitory regulator Ig_2 PF13895.4 001123143.1_49823001_1 - 1.6e-13 50.6 0.0 1e-06 28.8 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001123143.1_49823001_1 - 2.6e-10 40.6 0.0 1.7e-05 25.2 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001123143.1_49823001_1 - 1.6e-08 34.4 0.0 5.3e-06 26.4 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Phage_holin_2_4 PF16082.3 001123143.1_49823001_1 - 0.15 11.8 0.1 0.24 11.1 0.1 1.3 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like His_Phos_2 PF00328.20 001133641.1_43525001_1 - 2.3e-34 119.3 0.2 5.6e-32 111.4 0.2 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Apolipo_F PF15148.4 001003925.1_49822001_3 - 2e-78 262.4 0.2 2.4e-78 262.1 0.2 1.1 1 0 0 1 1 1 1 Apolipoprotein F BCDHK_Adom3 PF10436.7 001159608.1_49823001_2 - 2e-51 173.9 0.1 3e-51 173.3 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.24 001159608.1_49823001_2 - 7.3e-14 52.2 0.0 1.3e-13 51.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.4 001159608.1_49823001_2 - 0.0012 18.5 0.0 0.0023 17.6 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ANF_receptor PF01094.26 001123114.1_49824001_1 - 7.8e-72 242.2 0.0 9.3e-72 241.9 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.4 001123114.1_49824001_1 - 1.7e-20 73.9 0.0 2.8e-20 73.2 0.0 1.3 1 1 0 1 1 1 1 Periplasmic binding protein Sushi PF00084.18 001123114.1_49824001_1 - 4.2e-13 49.6 0.7 1.8e-07 31.5 0.1 2.6 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) Interferon PF00143.17 001123401.1_39522001_1 - 2.5e-64 216.1 1.0 3.1e-64 215.9 1.0 1.1 1 0 0 1 1 1 1 Interferon alpha/beta domain LisH PF08513.9 001123401.1_39522001_1 - 0.044 13.7 0.0 0.094 12.6 0.0 1.5 1 0 0 1 1 1 0 LisH MutS_V PF00488.19 001195358.1_49826001_3 - 3.2e-50 170.7 0.0 5.8e-50 169.8 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.16 001195358.1_49826001_3 - 5.5e-23 82.0 0.4 1e-22 81.1 0.4 1.5 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.16 001195358.1_49826001_3 - 4.5e-15 55.6 0.0 8.3e-15 54.8 0.0 1.5 1 0 0 1 1 1 1 MutS family domain IV Aa_trans PF01490.16 001131729.1_43529001_1 - 4.7e-19 68.2 23.2 1.1e-11 43.9 11.8 2.1 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.11 001131729.1_43529001_1 - 3.8e-06 26.1 17.3 0.0036 16.3 2.2 2.4 2 0 0 2 2 2 2 Tryptophan/tyrosine permease family Myosin_tail_1 PF01576.17 001168955.1_40428001_1 - 4.4e-36 124.0 192.5 4.4e-35 120.7 85.9 3.0 1 1 2 3 3 3 3 Myosin tail ADIP PF11559.6 001168955.1_40428001_1 - 0.0008 19.4 15.0 0.0008 19.4 15.0 10.7 2 2 7 11 11 11 3 Afadin- and alpha -actinin-Binding DUF1664 PF07889.10 001168955.1_40428001_1 - 0.0012 18.7 7.7 0.0012 18.7 7.7 9.5 3 2 5 9 9 9 5 Protein of unknown function (DUF1664) Reo_sigmaC PF04582.10 001168955.1_40428001_1 - 0.0089 15.3 32.6 0.01 15.1 3.8 6.0 3 2 3 6 6 6 4 Reovirus sigma C capsid protein CD34_antigen PF06365.10 001103354.2_45729001_1 - 0.00053 19.5 0.0 0.0009 18.8 0.0 1.2 1 0 0 1 1 1 1 CD34/Podocalyxin family EphA2_TM PF14575.4 001103354.2_45729001_1 - 0.097 13.4 0.1 3.3 8.5 0.0 2.5 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.4 001103354.2_45729001_1 - 1.4 8.7 2.6 3.9 7.3 0.0 2.1 2 0 0 2 2 2 0 TMEM154 protein family ANP PF00212.16 001160026.1_39521001_1 - 1.6e-15 56.8 6.1 1.6e-15 56.8 6.1 2.0 2 0 0 2 2 2 1 Atrial natriuretic peptide SMN PF06003.10 001160026.1_39521001_3 - 7.8 5.5 6.3 11 5.1 6.3 1.2 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Pro-MCH PF05824.10 001134768.1_39722001_1 - 7.6e-51 169.9 0.2 1.6e-50 168.8 0.0 1.6 2 0 0 2 2 2 1 Pro-melanin-concentrating hormone (Pro-MCH) ISK_Channel PF02060.13 001134768.1_39722001_1 - 0.12 12.0 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Slow voltage-gated potassium channel ADAM_spacer1 PF05986.12 001144843.1_49829001_1 - 4.2e-33 113.7 0.0 6.9e-33 113.0 0.0 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Pep_M12B_propep PF01562.17 001144843.1_49829001_1 - 1.1e-23 83.8 0.0 2.6e-22 79.4 0.0 2.3 2 0 0 2 2 2 1 Reprolysin family propeptide Reprolysin PF01421.17 001144843.1_49829001_1 - 2.1e-19 70.1 0.0 3.2e-19 69.5 0.0 1.3 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease TSP_1 PF00090.17 001144843.1_49829001_1 - 1.8e-18 66.4 46.0 5.8e-10 39.1 6.8 5.6 5 0 0 5 5 5 3 Thrombospondin type 1 domain Reprolysin_5 PF13688.4 001144843.1_49829001_1 - 1.9e-12 47.6 0.5 3.3e-12 46.8 0.5 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 001144843.1_49829001_1 - 8.6e-12 45.5 0.0 1.6e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 001144843.1_49829001_1 - 2.1e-05 24.2 0.1 3.3e-05 23.5 0.1 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 001144843.1_49829001_1 - 9.7e-05 22.2 0.1 0.00018 21.4 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_S10 PF00450.20 001131184.1_43524001_1 - 3.8e-103 346.0 0.3 5.4e-103 345.5 0.3 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase NNMT_PNMT_TEMT PF01234.15 001123164.1_49822001_1 - 3.6e-92 308.0 0.0 4.1e-92 307.9 0.0 1.0 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_23 PF13489.4 001123164.1_49822001_1 - 0.14 11.9 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain UPF0180 PF03698.11 001123164.1_49822001_1 - 0.19 11.8 0.0 0.84 9.7 0.0 2.0 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0180) Ephrin PF00812.15 001123110.1_49822001_1 - 1.7e-43 147.8 2.1 2.2e-43 147.4 2.1 1.1 1 0 0 1 1 1 1 Ephrin Sulfotransfer_1 PF00685.25 016771.3_32925001_1 - 1.1e-91 306.8 1.2 1.5e-91 306.5 1.2 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 016771.3_32925001_1 - 1.2e-06 29.0 0.1 0.00038 20.8 0.0 2.4 3 0 0 3 3 3 2 Sulfotransferase family GILT PF03227.14 001131046.1_49823001_3 - 1.3e-30 105.6 1.5 2.2e-30 104.9 1.5 1.4 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) Sarcoglycan_1 PF04790.11 001144123.1_49823001_2 - 7e-79 264.7 0.0 8.7e-79 264.4 0.0 1.1 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein DUF2345 PF10106.7 001144123.1_49823001_2 - 0.00097 18.9 0.0 0.0027 17.5 0.0 1.6 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2345) Defensin_beta_2 PF13841.4 001129757.1_39721001_1 - 1.2e-06 28.7 3.5 1.5e-06 28.4 3.5 1.2 1 0 0 1 1 1 1 Beta defensin RmlD_sub_bind PF04321.15 001142832.1_49824001_1 - 9e-85 284.1 0.0 1.1e-84 283.8 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.19 001142832.1_49824001_1 - 1e-23 83.9 0.0 1.4e-23 83.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 001142832.1_49824001_1 - 7.6e-11 41.8 0.1 1.6e-10 40.7 0.1 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.13 001142832.1_49824001_1 - 8.4e-08 31.6 0.2 1.2e-05 24.5 0.1 2.4 1 1 0 2 2 2 2 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.10 001142832.1_49824001_1 - 1.2e-05 24.5 0.0 0.0011 18.0 0.0 2.4 2 1 0 2 2 2 2 Male sterility protein DapB_N PF01113.18 001142832.1_49824001_1 - 0.12 12.3 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus CLN3 PF02487.15 001113051.1_49823001_1 - 3.3e-140 467.5 7.4 1e-139 465.9 7.4 1.6 1 1 0 1 1 1 1 CLN3 protein SH3_1 PF00018.26 001137631.1_49823001_1 - 5.4e-42 141.0 8.2 8e-14 50.8 0.0 3.7 4 0 0 4 4 4 3 SH3 domain SH3_9 PF14604.4 001137631.1_49823001_1 - 1.1e-41 140.2 4.4 2e-15 56.3 0.1 3.6 3 0 0 3 3 3 3 Variant SH3 domain SH3_2 PF07653.15 001137631.1_49823001_1 - 6.4e-31 105.7 3.7 8.5e-11 41.3 0.0 3.6 4 0 0 4 4 4 3 Variant SH3 domain SH2 PF00017.22 001137631.1_49823001_1 - 1.8e-21 75.9 0.1 3.5e-21 74.9 0.1 1.5 1 0 0 1 1 1 1 SH2 domain SH3_3 PF08239.9 001137631.1_49823001_1 - 4.1e-10 39.7 8.9 0.0027 17.8 0.4 3.5 3 0 0 3 3 3 3 Bacterial SH3 domain hSH3 PF14603.4 001137631.1_49823001_1 - 6.9e-06 26.4 0.0 0.0017 18.7 0.0 2.8 3 0 0 3 3 3 1 Helically-extended SH3 domain SH2_2 PF14633.4 001137631.1_49823001_1 - 0.0032 16.7 0.1 0.014 14.6 0.1 1.8 1 1 0 1 1 1 1 SH2 domain SH3_4 PF06347.11 001137631.1_49823001_1 - 0.22 11.3 6.8 1.3 8.7 0.5 3.2 3 0 0 3 3 3 0 Bacterial SH3 domain DUF2284 PF10050.7 001137631.1_49823001_2 - 0.1 12.2 2.6 0.067 12.8 1.0 1.4 2 0 0 2 2 2 0 Predicted metal-binding protein (DUF2284) CALCOCO1 PF07888.9 001132866.1_43527001_3 - 1.8e-29 102.7 2.8 1.8e-29 102.7 2.8 2.2 1 1 1 2 2 2 1 Calcium binding and coiled-coil domain (CALCOCO1) like NAD_binding_10 PF13460.4 001132866.1_43527001_3 - 0.18 11.6 0.2 0.3 10.8 0.2 1.2 1 0 0 1 1 1 0 NAD(P)H-binding DUF2126 PF09899.7 001132866.1_43527001_3 - 0.91 7.4 12.1 1.3 6.9 12.1 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Glyco_transf_7N PF13733.4 001134209.1_43524001_1 - 1.2e-56 190.0 0.0 1.6e-56 189.5 0.0 1.2 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.12 001134209.1_43524001_1 - 3.9e-30 103.2 0.1 1.1e-29 101.7 0.0 1.8 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Ras PF00071.20 001123189.1_49822001_1 - 2.6e-57 192.8 0.0 3.3e-57 192.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001123189.1_49822001_1 - 2.6e-23 82.4 0.0 4e-23 81.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001123189.1_49822001_1 - 1.7e-10 40.5 0.0 3.2e-10 39.6 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001123189.1_49822001_1 - 0.00013 21.4 0.0 0.00027 20.4 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001123189.1_49822001_1 - 0.029 14.1 0.0 0.13 12.0 0.0 2.0 2 1 0 2 2 2 0 Protein of unknown function, DUF258 Gtr1_RagA PF04670.10 001123189.1_49822001_1 - 0.037 13.3 0.0 0.056 12.7 0.0 1.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.8 001123189.1_49822001_1 - 0.047 13.0 0.0 0.076 12.3 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit PAP2 PF01569.19 001113445.1_49823001_1 - 2.6e-15 56.3 2.7 2.6e-15 56.3 2.7 2.0 1 1 0 1 1 1 1 PAP2 superfamily DUF373 PF04123.11 001113445.1_49823001_1 - 0.14 11.4 0.1 0.4 9.9 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF373) Colipase-like PF15083.4 001135002.1_45721001_3 - 6.6e-13 48.5 11.4 9.3e-13 48.0 11.4 1.2 1 0 0 1 1 1 1 Colipase-like Defensin_beta_2 PF13841.4 001129760.1_39721001_1 - 1.2e-08 35.2 13.1 1.5e-08 34.8 13.1 1.2 1 0 0 1 1 1 1 Beta defensin Defensin_beta PF00711.17 001129760.1_39721001_1 - 0.005 16.7 12.0 0.0064 16.4 12.0 1.1 1 0 0 1 1 1 1 Beta defensin Bim_N PF06773.9 001160074.1_49821001_1 - 2.2e-22 78.3 6.6 2.2e-22 78.3 6.6 1.9 1 1 1 2 2 2 1 Bim protein N-terminus Bclx_interact PF08945.8 001160074.1_49821001_1 - 4.2e-22 77.5 1.7 8e-22 76.6 1.7 1.5 1 0 0 1 1 1 1 Bcl-x interacting, BH3 domain PMAIP1 PF15150.4 001160074.1_49821001_1 - 0.048 13.4 0.6 0.12 12.1 0.0 1.9 1 1 1 2 2 2 0 Phorbol-12-myristate-13-acetate-induced WBP-1 PF11669.6 001127484.1_45728001_3 - 1.1e-43 147.9 11.7 1.1e-43 147.9 11.7 2.0 2 0 0 2 2 2 1 WW domain-binding protein 1 Trypsin PF00089.24 001123005.1_39522001_1 - 2.1e-55 187.8 0.0 2.5e-55 187.6 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001123005.1_39522001_1 - 4.9e-05 24.1 0.0 7.8e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S29 PF02907.13 001123005.1_39522001_1 - 0.091 12.4 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease 7tm_2 PF00002.22 001144118.1_49823001_1 - 2.1e-77 259.6 22.9 2.7e-77 259.3 22.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 001144118.1_49823001_1 - 5.2e-19 68.2 2.1 1.3e-18 66.9 2.1 1.7 1 0 0 1 1 1 1 Hormone receptor domain WW PF00397.24 001144118.1_49823001_1 - 0.0053 16.5 0.0 0.012 15.4 0.0 1.6 1 0 0 1 1 1 1 WW domain PAS_4 PF08448.8 001144118.1_49823001_1 - 0.092 12.9 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 PAS fold CBFD_NFYB_HMF PF00808.21 001133412.1_43525001_2 - 1.7e-12 47.3 0.1 3e-12 46.5 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.4 001133412.1_43525001_2 - 0.0066 16.4 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.22 001133412.1_43525001_2 - 0.01 16.1 0.0 0.01 16.1 0.0 2.2 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 Afi1 PF07792.10 001133412.1_43525001_2 - 0.037 14.4 5.7 0.07 13.5 5.7 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking BUD22 PF09073.8 001133412.1_43525001_2 - 0.098 11.8 15.6 0.14 11.4 15.6 1.1 1 0 0 1 1 1 0 BUD22 DUF4746 PF15928.3 001133412.1_43525001_2 - 0.26 10.5 10.9 0.36 10.1 10.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DDHD PF02862.15 001133412.1_43525001_2 - 0.37 10.7 2.5 0.5 10.3 2.5 1.1 1 0 0 1 1 1 0 DDHD domain Mtc1 PF10310.7 001133412.1_43525001_2 - 0.64 8.8 14.1 0.88 8.3 14.1 1.0 1 0 0 1 1 1 0 Maintenance of telomere capping protein 1 Vfa1 PF08432.8 001133412.1_43525001_2 - 1.8 8.7 15.9 2.8 8.1 15.9 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 NOA36 PF06524.10 001133412.1_43525001_2 - 2.5 7.3 13.7 3.8 6.7 13.7 1.3 1 0 0 1 1 1 0 NOA36 protein Pox_Ag35 PF03286.12 001133412.1_43525001_2 - 4.9 6.8 15.4 7 6.3 15.4 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF3464 PF11947.6 001133412.1_43525001_2 - 8.4 6.0 6.7 18 4.9 6.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) DUF1510 PF07423.9 001133412.1_43525001_2 - 9.5 5.5 19.3 14 4.9 19.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CobT PF06213.10 001133412.1_43525001_2 - 9.6 5.4 18.3 14 4.8 18.3 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT COesterase PF00135.26 001131784.1_43528001_1 - 4.3e-153 510.8 0.0 5.1e-153 510.5 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 001131784.1_43528001_1 - 2.5e-09 37.2 0.4 5e-09 36.2 0.4 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 001131784.1_43528001_1 - 0.038 13.3 0.1 0.065 12.6 0.1 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family PNISR PF15996.3 001113439.1_49827001_3 - 7.5e-51 173.1 18.8 7.5e-51 173.1 18.8 5.7 2 2 2 4 4 4 1 Arginine/serine-rich protein PNISR CD20 PF04103.13 001114174.1_32926001_2 - 6e-31 107.5 11.9 9.2e-31 106.9 11.9 1.3 1 0 0 1 1 1 1 CD20-like family DAGK_cat PF00781.22 001143699.1_49826001_1 - 1.2e-24 86.2 0.2 1.7e-24 85.7 0.2 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Tim54 PF11711.6 001143699.1_49826001_1 - 0.0006 18.6 0.0 0.00096 17.9 0.0 1.2 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 NAD_kinase PF01513.19 001143699.1_49826001_1 - 0.0024 17.0 0.1 0.0036 16.4 0.1 1.1 1 0 0 1 1 1 1 ATP-NAD kinase GATase PF00117.26 001143699.1_49826001_1 - 0.087 12.4 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferase class-I Peptidase_S51 PF03575.15 001143699.1_49826001_1 - 0.13 11.7 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Peptidase family S51 NNMT_PNMT_TEMT PF01234.15 001123146.1_49822001_1 - 2.2e-99 331.7 0.0 2.5e-99 331.5 0.0 1.0 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_25 PF13649.4 001123146.1_49822001_1 - 0.00042 20.9 0.0 0.77 10.4 0.0 2.6 2 1 1 3 3 3 2 Methyltransferase domain Methyltransf_11 PF08241.10 001123146.1_49822001_1 - 0.0017 18.8 0.0 0.043 14.3 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 001123146.1_49822001_1 - 0.011 15.5 0.0 0.021 14.6 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.10 001123146.1_49822001_1 - 0.025 15.2 0.0 0.12 13.0 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain LEAP-2 PF07359.9 001114110.1_29621001_1 - 3.8e-44 148.3 2.9 4.2e-44 148.1 2.9 1.0 1 0 0 1 1 1 1 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) EB PF01683.16 001114110.1_29621001_1 - 0.0016 18.5 0.1 0.0016 18.5 0.1 1.1 1 0 0 1 1 1 1 EB module zf-H2C2_2 PF13465.4 001113449.1_49826001_3 - 3e-39 131.6 80.9 2e-07 31.0 2.6 11.4 12 0 0 12 12 12 8 Zinc-finger double domain zf-H2C2_5 PF13909.4 001113449.1_49826001_3 - 3.5e-36 122.5 72.7 2.1e-08 33.7 2.7 10.2 10 0 0 10 10 10 8 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 001113449.1_49826001_3 - 8.3e-30 101.4 91.4 0.0004 20.5 3.6 11.2 11 0 0 11 11 11 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001113449.1_49826001_3 - 1.7e-17 62.4 88.8 0.026 15.2 2.6 11.5 11 0 0 11 11 11 10 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001113449.1_49826001_3 - 2.9e-08 33.3 2.2 2.9e-08 33.3 2.2 10.2 12 0 0 12 12 12 3 C2H2-type zinc finger zf-met PF12874.5 001113449.1_49826001_3 - 0.00031 20.9 8.7 0.0023 18.1 2.1 9.8 11 1 0 11 11 11 6 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 001113449.1_49826001_3 - 0.011 15.4 0.1 0.011 15.4 0.1 7.8 8 0 0 8 8 8 0 zinc-finger C2H2-type Peptidase_C74 PF12387.6 001113449.1_49826001_3 - 1.3 8.3 3.7 2.6 7.4 3.7 1.4 1 0 0 1 1 1 0 Pestivirus NS2 peptidase Med3 PF11593.6 001113449.1_49826001_3 - 1.6 7.7 8.5 3.3 6.7 8.5 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Syntaxin-6_N PF09177.9 001133027.1_43529001_1 - 1.4e-37 128.1 0.9 1.4e-37 128.1 0.9 2.1 2 1 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.17 001133027.1_43529001_1 - 3.8e-11 42.7 0.7 1e-10 41.3 0.7 1.8 1 0 0 1 1 1 1 SNARE domain FliD_C PF07195.10 001133027.1_43529001_1 - 0.039 13.2 2.5 0.23 10.7 0.0 2.1 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus FAM75 PF14650.4 001008359.2_45727001_1 - 1.3e-107 360.6 17.6 1.3e-107 360.6 17.6 4.2 4 0 0 4 4 4 2 FAM75 family Interferon PF00143.17 001123400.1_39522001_2 - 4.4e-64 215.3 0.4 5.3e-64 215.1 0.4 1.1 1 0 0 1 1 1 1 Interferon alpha/beta domain LisH PF08513.9 001123400.1_39522001_2 - 0.02 14.8 0.1 0.043 13.7 0.1 1.5 1 0 0 1 1 1 0 LisH Defensin_beta_2 PF13841.4 001129767.1_39721001_1 - 5.5e-09 36.2 12.9 6.8e-09 35.9 12.9 1.1 1 0 0 1 1 1 1 Beta defensin COE1_HLH PF16423.3 001131239.1_43526001_1 - 0.18 11.4 0.0 0.32 10.6 0.0 1.4 1 0 0 1 1 1 0 Transcription factor COE1 helix-loop-helix domain 7tm_1 PF00001.19 001131239.1_43526001_3 - 1.7e-47 161.8 16.1 2e-47 161.5 16.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001131239.1_43526001_3 - 7.9e-12 45.0 14.3 3.1e-11 43.0 14.3 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001131239.1_43526001_3 - 1.7e-08 34.4 10.2 7.2e-08 32.4 10.2 1.8 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001131239.1_43526001_3 - 0.15 11.2 10.8 0.083 12.1 8.9 1.6 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx zf-C3HC4_3 PF13920.4 001132846.1_43528001_1 - 5.6e-09 35.6 10.6 1.1e-08 34.6 10.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001132846.1_43528001_1 - 1.4e-08 34.7 14.4 3e-08 33.6 14.4 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 001132846.1_43528001_1 - 4.5e-08 32.7 13.6 1e-07 31.5 13.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001132846.1_43528001_1 - 1.3e-05 24.8 13.2 2.7e-05 23.8 13.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001132846.1_43528001_1 - 0.00013 21.8 11.4 0.00014 21.6 9.5 2.2 2 0 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.4 001132846.1_43528001_1 - 0.00013 21.6 13.4 0.00014 21.5 10.8 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.5 001132846.1_43528001_1 - 0.00023 21.3 9.5 0.00052 20.1 9.5 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.4 001132846.1_43528001_1 - 0.0025 17.6 13.9 0.01 15.7 13.2 2.3 1 1 1 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.5 001132846.1_43528001_1 - 0.3 11.0 4.6 0.62 10.0 4.6 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.4 001132846.1_43528001_1 - 0.35 10.9 11.3 0.84 9.7 11.3 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING ANF_receptor PF01094.26 001114547.1_22426001_1 - 2.7e-71 240.4 0.0 3.4e-71 240.1 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.20 001114547.1_22426001_1 - 2.9e-29 102.4 10.7 5.1e-29 101.6 10.7 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.12 001114547.1_22426001_1 - 1.3e-13 50.5 13.6 2.8e-13 49.5 13.6 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.4 001114547.1_22426001_1 - 7e-09 35.7 0.6 2e-08 34.2 0.1 1.9 3 0 0 3 3 3 1 Periplasmic binding protein TAFII28 PF04719.12 001133930.2_43524001_1 - 7.6e-40 134.8 0.4 2.9e-39 133.0 0.1 2.0 2 0 0 2 2 2 1 hTAFII28-like protein conserved region CBFD_NFYB_HMF PF00808.21 001133930.2_43524001_1 - 2.1e-05 24.5 0.0 4e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone EamA PF00892.18 001127658.1_45723001_1 - 1.4e-10 41.4 25.1 2.3e-06 27.7 3.6 2.3 2 1 0 2 2 2 2 EamA-like transporter family DUF2070 PF09843.7 001127658.1_45723001_1 - 5 5.2 7.6 6.8 4.7 7.6 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Calc_CGRP_IAPP PF00214.17 001130155.1_39522001_1 - 8.5e-47 158.3 0.0 1.1e-46 158.0 0.0 1.1 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family Cation_efflux PF01545.19 001137624.1_49825001_2 - 1.8e-48 164.8 13.7 1.8e-48 164.8 13.7 3.3 4 1 0 4 4 4 1 Cation efflux family BRO1 PF03097.16 001131616.1_43529001_1 - 6e-41 140.4 0.6 8.5e-41 139.9 0.6 1.1 1 0 0 1 1 1 1 BRO1-like domain ANP PF00212.16 001160027.1_39521001_1 - 2.3e-11 43.5 3.3 4.2e-11 42.7 3.3 1.5 1 0 0 1 1 1 1 Atrial natriuretic peptide Transferrin PF00405.15 001144835.1_39725001_1 - 7.4e-268 886.4 11.5 1.4e-174 579.8 0.4 2.0 2 0 0 2 2 2 2 Transferrin Phosphonate-bd PF12974.5 001144835.1_39725001_1 - 1.2e-12 47.9 0.0 6.8e-06 25.7 0.0 2.6 2 1 0 2 2 2 2 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.18 001144835.1_39725001_1 - 0.013 14.8 0.1 1.8 7.8 0.0 2.7 2 1 0 2 2 2 0 Bacterial extracellular solute-binding proteins, family 3 MBOAT PF03062.17 001108016.2_45726001_1 - 1e-28 100.5 15.4 4.8e-28 98.4 15.4 1.8 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family adh_short PF00106.23 001348961.2_49823001_2 - 1.1e-34 119.4 0.3 1.6e-34 118.9 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001348961.2_49823001_2 - 8.4e-13 48.3 0.1 1.1e-12 47.9 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.8 001348961.2_49823001_2 - 0.0033 16.7 0.0 0.005 16.1 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) MAGE PF01454.17 001302428.1_39725001_1 - 3.1e-07 30.2 0.3 4.1e-05 23.2 0.0 2.6 3 0 0 3 3 3 2 MAGE family KRAB PF01352.25 001001737.2_32929001_2 - 6.1e-20 70.5 0.2 1e-19 69.8 0.2 1.4 1 0 0 1 1 1 1 KRAB box DUF2315 PF10231.7 126431.1_26223120_1 - 9.2e-52 174.3 6.9 1.3e-51 173.8 6.9 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2315) CHDCT2 PF08074.9 126509.1_32929120_1 - 0.017 15.2 0.0 0.39 10.7 0.0 2.1 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain SNF2_N PF00176.21 126509.1_32929120_2 - 3e-64 216.8 1.4 4.6e-64 216.2 1.4 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.22 126509.1_32929120_2 - 2.3e-23 81.7 4.1 4.8e-13 48.6 1.4 2.6 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.13 126509.1_32929120_2 - 2.5e-07 30.7 0.0 5e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.27 126509.1_32929120_2 - 0.0002 21.0 0.0 0.00041 20.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase COX16 PF14138.4 132134.1_32924120_3 - 2.8e-06 27.6 0.0 4.4e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 WH1 PF00568.21 001328283.1_39725001_1 - 7.7e-40 135.2 0.2 1.5e-39 134.2 0.2 1.4 1 0 0 1 1 1 1 WH1 domain VASP_tetra PF08776.9 001328283.1_39725001_1 - 1.1e-17 63.1 3.3 2.3e-17 62.1 3.3 1.5 1 0 0 1 1 1 1 VASP tetramerisation domain Uteroglobin PF01099.15 001310561.1_31321001_2 - 1.6e-13 50.5 0.9 2.3e-13 50.0 0.9 1.3 1 0 0 1 1 1 1 Uteroglobin family DUF1438 PF07270.9 199060.2_32922001_2 - 5.9e-92 305.5 3.0 8.2e-92 305.0 3.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1438) Collagen PF01391.16 134850.1_26229120_1 - 1.4e-49 165.5 175.0 2.7e-09 36.5 20.6 6.3 2 2 4 6 6 6 6 Collagen triple helix repeat (20 copies) VWA PF00092.26 134850.1_26229120_2 - 4.6e-45 153.9 0.2 6.7e-45 153.3 0.2 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.4 134850.1_26229120_2 - 2.4e-14 53.8 0.0 4.2e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Collagen PF01391.16 134850.1_26229120_2 - 3.2e-05 23.5 8.9 3.2e-05 23.5 8.9 1.7 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) Laminin_G_2 PF02210.22 134850.1_26229120_2 - 0.01 16.3 0.0 0.025 15.0 0.0 1.6 1 0 0 1 1 1 0 Laminin G domain Laminin_G_3 PF13385.4 134850.1_26229120_2 - 0.045 13.8 0.0 0.079 13.0 0.0 1.3 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily Collagen PF01391.16 134850.1_26229120_3 - 3.4e-17 61.8 49.9 4.5e-10 39.0 21.5 2.8 2 1 1 3 3 3 2 Collagen triple helix repeat (20 copies) PCNP PF15473.4 135230.1_26225120_2 - 6.5e-46 156.8 10.6 1.8e-34 119.6 2.9 2.1 1 1 1 2 2 2 2 PEST, proteolytic signal-containing nuclear protein family PCNP PF15473.4 135231.1_26225120_1 - 5.6e-35 121.3 2.6 7.8e-35 120.8 2.6 1.1 1 0 0 1 1 1 1 PEST, proteolytic signal-containing nuclear protein family CtaG_Cox11 PF04442.12 027941.2_26223120_2 - 8.2e-33 113.4 0.0 1.1e-32 113.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 UCR_Fe-S_N PF10399.7 027941.2_26223120_2 - 0.016 14.4 0.1 0.045 13.0 0.1 1.8 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal RSRP PF17069.3 135792.1_26227120_3 - 9 5.6 43.2 20 4.5 43.2 1.5 1 1 0 1 1 1 0 Arginine/Serine-Rich protein 1 FAM219A PF15260.4 135841.1_26227120_1 - 4.9e-08 33.3 0.0 8.7e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Protein family FAM219A FAM219A PF15260.4 135841.1_26227120_2 - 9.4e-34 116.3 5.0 1.4e-33 115.8 5.0 1.2 1 0 0 1 1 1 1 Protein family FAM219A Gp_dh_C PF02800.18 001172951.1_09923001_3 - 2.4e-70 235.1 0.0 3.5e-70 234.5 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.22 001172951.1_09923001_3 - 5.8e-39 132.4 0.3 1.3e-38 131.3 0.2 1.6 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 7tm_1 PF00001.19 001009135.3_39724001_3 - 5.8e-38 130.5 21.5 1.1e-37 129.6 21.5 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Renin_r PF07850.12 001009135.3_39724001_3 - 0.11 12.9 0.6 2.7 8.5 0.2 2.7 2 0 0 2 2 2 0 Renin receptor-like protein PMP22_Claudin PF00822.18 001161638.1_49822001_1 - 1.5e-22 80.1 7.4 1.9e-22 79.8 7.4 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001161638.1_49822001_1 - 3.7e-06 26.7 10.9 8e-06 25.6 10.0 1.9 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF4064 PF13273.4 001161638.1_49822001_1 - 0.00082 19.6 6.7 2.2 8.6 0.0 3.0 2 1 0 2 2 2 1 Protein of unknown function (DUF4064) DUF4383 PF14325.4 001161638.1_49822001_1 - 0.11 12.6 0.3 0.11 12.6 0.3 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4383) Clc-like PF07062.10 001161638.1_49822001_1 - 0.18 11.1 0.1 0.18 11.1 0.1 2.3 1 1 1 2 2 2 0 Clc-like TMEM37 PF15108.4 001161638.1_49822001_1 - 0.99 9.1 7.4 0.21 11.3 2.8 1.9 1 1 1 2 2 2 0 Voltage-dependent calcium channel gamma-like subunit protein family Amastin PF07344.9 001161638.1_49822001_1 - 1.6 8.4 9.9 2.8 7.6 8.4 1.9 1 1 1 2 2 2 0 Amastin surface glycoprotein Cementoin PF10511.7 001172730.1_09925001_1 - 8.7e-53 173.7 71.3 2.3e-07 30.3 2.1 11.0 10 0 0 10 10 10 8 Trappin protein transglutaminase binding domain DUF3301 PF11743.6 001172730.1_09925001_1 - 1.1e-07 31.3 10.5 5.7 6.6 0.0 7.0 2 2 5 7 7 7 5 Protein of unknown function (DUF3301) Ribosomal_L35p PF01632.17 001172730.1_09925001_1 - 1.5e-05 25.2 7.8 1.8 9.0 0.0 6.0 2 2 5 7 7 7 3 Ribosomal protein L35 PP1 PF07430.9 001172730.1_09925001_1 - 0.002 18.0 0.0 64 3.6 0.0 4.6 1 1 4 5 5 5 0 Phloem filament protein PP1 cystatin-like domain Bactofilin PF04519.11 001172730.1_09925001_1 - 0.02 15.0 3.8 4.4 7.5 0.9 2.9 1 1 1 2 2 2 0 Polymer-forming cytoskeletal 7tm_1 PF00001.19 001171082.1_37923001_2 - 6.1e-57 192.8 14.7 6.1e-57 192.8 14.7 1.8 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171082.1_37923001_2 - 0.00038 19.8 12.1 0.00056 19.2 12.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TrbC PF04956.11 001171082.1_37923001_2 - 6.8 6.9 6.7 9.1 6.4 0.0 2.7 3 0 0 3 3 3 0 TrbC/VIRB2 family Pkinase PF00069.23 001177919.1_49829001_2 - 4.6e-60 203.1 0.0 6.5e-59 199.3 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001177919.1_49829001_2 - 1.3e-27 96.6 0.0 1.2e-19 70.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase UBA PF00627.29 001177919.1_49829001_2 - 0.016 15.0 0.2 0.027 14.2 0.2 1.4 1 0 0 1 1 1 0 UBA/TS-N domain Pox_ser-thr_kin PF05445.9 001177919.1_49829001_2 - 0.021 13.7 0.1 0.031 13.1 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase APH PF01636.21 001177919.1_49829001_2 - 0.026 14.3 2.3 0.059 13.1 0.2 2.5 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.12 001177919.1_49829001_2 - 0.029 13.6 0.0 0.051 12.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_C PF00433.22 001177919.1_49829001_2 - 0.088 13.4 0.1 0.23 12.1 0.1 1.8 1 0 0 1 1 1 0 Protein kinase C terminal domain EBP PF05241.10 001172945.1_09923001_3 - 6.6e-57 191.7 12.4 9.6e-57 191.2 12.4 1.2 1 0 0 1 1 1 1 Emopamil binding protein Rft-1 PF04506.11 001172945.1_09923001_3 - 0.032 12.9 1.0 0.05 12.2 1.0 1.3 1 0 0 1 1 1 0 Rft protein Complex1_LYR PF05347.13 001173471.1_45724001_1 - 4.7e-13 48.9 0.1 7.8e-13 48.1 0.1 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.4 001173471.1_45724001_1 - 0.011 16.4 0.5 0.018 15.7 0.5 1.3 1 0 0 1 1 1 0 Complex1_LYR-like Complex1_LYR_1 PF13232.4 001173471.1_45724001_1 - 0.13 12.7 0.0 0.27 11.7 0.0 1.5 1 0 0 1 1 1 0 Complex1_LYR-like zf-HC5HC2H PF13771.4 172603.3_32923001_1 - 2e-18 66.3 3.5 2e-18 66.3 3.5 2.2 2 0 0 2 2 2 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.4 172603.3_32923001_1 - 4.2e-06 26.7 4.7 4.2e-06 26.7 4.7 1.8 2 0 0 2 2 2 1 PHD-zinc-finger like domain C1_2 PF03107.14 172603.3_32923001_1 - 0.11 12.8 3.1 1 9.6 0.8 2.7 2 0 0 2 2 2 0 C1 domain Zf_RING PF16744.3 172603.3_32923001_1 - 0.19 11.7 2.8 2 8.4 0.4 2.5 2 0 0 2 2 2 0 KIAA1045 RING finger hemP PF10636.7 172603.3_32923001_2 - 0.092 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Hemin uptake protein hemP ROK PF00480.18 001167630.1_49824001_1 - 3.7e-55 187.4 2.0 5.5e-55 186.8 2.0 1.3 1 0 0 1 1 1 1 ROK family Epimerase_2 PF02350.17 001167630.1_49824001_1 - 5.1e-29 101.1 0.0 9e-29 100.3 0.0 1.4 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase FGGY_N PF00370.19 001167630.1_49824001_1 - 0.00055 19.4 0.0 0.00093 18.7 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Hexokinase_1 PF00349.19 001167630.1_49824001_1 - 0.0045 16.9 0.0 0.0084 16.0 0.0 1.4 1 0 0 1 1 1 1 Hexokinase BcrAD_BadFG PF01869.18 001167630.1_49824001_1 - 0.022 14.1 0.9 0.58 9.5 0.9 2.3 1 1 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family Glucokinase PF02685.14 001167630.1_49824001_1 - 0.25 10.2 0.0 0.25 10.2 0.0 2.6 3 1 1 4 4 4 0 Glucokinase Glyco_transf_29 PF00777.16 001194932.1_39724001_1 - 3.4e-38 131.4 0.0 6.1e-38 130.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) 7tm_1 PF00001.19 001172912.1_09923001_1 - 3.3e-77 259.2 6.0 4.1e-77 258.9 6.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001172912.1_09923001_1 - 3e-16 59.4 5.3 4.5e-16 58.9 5.3 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001172912.1_09923001_1 - 6.3e-05 22.7 5.5 0.00035 20.3 3.0 2.3 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001172912.1_09923001_1 - 0.00058 19.1 6.3 0.00058 19.1 6.3 1.5 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_7 PF08395.10 001172912.1_09923001_1 - 0.37 9.8 14.0 0.9 8.5 0.1 3.1 2 1 1 3 3 3 0 7tm Chemosensory receptor 7tm_1 PF00001.19 001172846.1_09923001_1 - 2e-73 246.8 0.0 2.4e-73 246.5 0.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001172846.1_09923001_1 - 1.2e-08 35.0 5.7 2.7e-06 27.2 3.6 2.2 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001172846.1_09923001_1 - 4.8e-08 32.6 13.4 2.7e-06 26.8 3.5 2.3 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001172846.1_09923001_1 - 1.4e-05 24.4 12.2 9.2e-05 21.8 5.7 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srx COX3 PF00510.16 001171073.1_37925001_1 - 1.1e-43 149.8 12.5 1.6e-43 149.3 12.5 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit III 7tm_1 PF00001.19 001171073.1_37925001_2 - 8.2e-49 166.1 13.7 1e-48 165.8 13.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171073.1_37925001_2 - 2.3e-12 46.7 11.8 1.8e-11 43.8 11.8 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171073.1_37925001_2 - 1.7e-09 37.7 8.9 6.5e-09 35.8 8.9 1.8 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001171073.1_37925001_2 - 0.0054 15.9 3.8 0.0054 15.9 3.8 1.8 3 0 0 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx Piwi PF02171.15 001194972.1_49826001_1 - 9.6e-104 346.7 0.0 1.5e-103 346.0 0.0 1.3 1 0 0 1 1 1 1 Piwi domain ArgoMid PF16487.3 001194972.1_49826001_1 - 3e-33 113.8 0.3 1.1e-32 112.0 0.1 2.1 2 0 0 2 2 2 1 Mid domain of argonaute PAZ PF02170.20 001194972.1_49826001_1 - 4.7e-29 100.8 2.0 7.7e-29 100.1 2.0 1.4 1 0 0 1 1 1 1 PAZ domain ArgoN PF16486.3 001194972.1_49826001_1 - 1.2e-27 97.1 0.0 3.2e-27 95.6 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.8 001194972.1_49826001_1 - 4.4e-23 80.5 0.1 9.6e-23 79.4 0.1 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.3 001194972.1_49826001_1 - 1.9e-15 56.8 0.0 4.4e-15 55.6 0.0 1.7 1 0 0 1 1 1 1 Argonaute linker 2 domain Amelogenin PF02948.13 001172869.1_09922001_2 - 1.3e-55 188.6 65.0 7.2e-39 134.1 49.4 2.8 1 1 1 2 2 2 2 Amelogenin TFIIA PF03153.11 001172869.1_09922001_2 - 9.4 6.0 9.5 10 5.9 9.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit zf-H2C2_2 PF13465.4 001195373.1_49828001_1 - 5.5e-28 96.0 80.2 4.1e-07 30.0 0.3 12.0 12 0 0 12 12 12 7 Zinc-finger double domain BTB PF00651.29 001195373.1_49828001_1 - 3.4e-22 78.6 0.1 6.3e-22 77.8 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 001195373.1_49828001_1 - 8.5e-21 73.1 79.5 2.7e-06 27.4 2.7 10.8 10 0 0 10 10 10 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001195373.1_49828001_1 - 2.5e-18 65.0 83.3 0.01 16.5 1.9 11.2 11 0 0 11 11 11 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001195373.1_49828001_1 - 1.5e-08 34.6 46.0 0.0066 16.6 0.2 9.5 10 0 0 10 10 10 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001195373.1_49828001_1 - 3.1e-08 33.2 55.2 0.31 10.9 1.0 9.7 9 0 0 9 9 9 7 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001195373.1_49828001_1 - 1e-06 28.3 1.4 1e-06 28.3 1.4 7.0 8 0 0 8 8 8 2 zinc-finger C2H2-type zf-C2H2_8 PF15909.3 001195373.1_49828001_1 - 0.00033 20.8 1.7 0.00033 20.8 1.7 5.5 4 2 2 6 6 6 1 C2H2-type zinc ribbon zf-met PF12874.5 001195373.1_49828001_1 - 0.0026 18.0 0.1 0.0026 18.0 0.1 8.3 8 0 0 8 8 8 2 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.4 001195373.1_49828001_1 - 0.018 14.8 23.8 0.054 13.3 0.5 7.2 6 0 0 6 6 6 0 zinc-finger of a C2HC-type Pkinase_Tyr PF07714.15 001195335.1_49826001_1 - 3.1e-99 331.4 0.0 4.4e-99 330.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.17 001195335.1_49826001_1 - 3.7e-70 235.5 0.1 7.5e-70 234.4 0.1 1.5 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.23 001195335.1_49826001_1 - 7.6e-49 166.3 0.0 1.3e-48 165.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.19 001195335.1_49826001_1 - 1.1e-31 108.9 5.2 1.6e-15 57.1 0.7 3.1 3 0 0 3 3 2 2 Fibronectin type III domain EphA2_TM PF14575.4 001195335.1_49826001_1 - 3.5e-21 75.7 0.0 8.6e-21 74.4 0.0 1.7 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SAM_1 PF00536.28 001195335.1_49826001_1 - 5.3e-14 52.3 0.0 9.8e-14 51.4 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 001195335.1_49826001_1 - 6.1e-14 51.8 0.0 1.3e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ephrin_rec_like PF07699.11 001195335.1_49826001_1 - 1.2e-07 31.2 4.0 1.2e-07 31.2 4.0 2.7 2 1 0 2 2 2 1 Putative ephrin-receptor like Pur_ac_phosph_N PF16656.3 001195335.1_49826001_1 - 1.8e-07 31.5 0.4 3.6e-05 24.1 0.5 2.6 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.3 001195335.1_49826001_1 - 0.00023 21.1 0.8 0.19 11.8 0.0 2.8 3 0 0 3 3 2 2 Fibronectin type III domain DUF2369 PF10179.7 001195335.1_49826001_1 - 0.0008 19.7 0.6 1.3 9.4 0.0 2.5 1 1 1 2 2 2 2 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.8 001195335.1_49826001_1 - 0.0048 17.1 0.0 0.31 11.2 0.1 3.1 3 0 0 3 3 3 1 Interferon-alpha/beta receptor, fibronectin type III Kdo PF06293.12 001195335.1_49826001_1 - 0.014 14.6 0.0 0.023 13.9 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zinc_ribbon_5 PF13719.4 001195335.1_49826001_1 - 0.022 14.4 7.2 13 5.5 0.2 4.0 3 0 0 3 3 3 0 zinc-ribbon domain SusE PF14292.4 001195335.1_49826001_1 - 0.054 13.8 0.1 0.36 11.1 0.1 2.4 2 0 0 2 2 2 0 SusE outer membrane protein TMEM154 PF15102.4 001195335.1_49826001_1 - 0.075 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family Rax2 PF12768.5 001195335.1_49826001_1 - 0.082 12.4 0.1 0.52 9.7 0.0 2.1 2 0 0 2 2 2 0 Cortical protein marker for cell polarity cEGF PF12662.5 001195335.1_49826001_1 - 0.3 10.9 7.8 3.8 7.4 0.3 2.9 2 0 0 2 2 2 0 Complement Clr-like EGF-like DUF2318 PF10080.7 001195335.1_49826001_1 - 5.1 7.2 7.0 1.6 8.7 2.2 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) 7tm_1 PF00001.19 001172991.1_09926001_2 - 6.6e-61 205.7 11.7 9e-61 205.3 11.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001172991.1_09926001_2 - 1.6e-12 47.2 9.9 2.2e-12 46.8 9.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 001172991.1_09926001_2 - 1.7e-08 34.1 3.8 2.2e-08 33.7 3.2 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 001172991.1_09926001_2 - 2.3e-07 30.7 13.8 2.4e-06 27.4 13.8 2.0 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001172991.1_09926001_2 - 2.6e-05 23.6 7.8 5e-05 22.6 7.7 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx V1R PF03402.12 001172991.1_09926001_2 - 1.3 8.4 6.6 0.21 11.1 0.4 2.3 2 1 1 3 3 3 0 Vomeronasal organ pheromone receptor family, V1R Hormone_1 PF00103.18 001197168.1_39722001_1 - 1.6e-62 210.9 0.2 1.8e-62 210.8 0.2 1.0 1 0 0 1 1 1 1 Somatotropin hormone family DUF594 PF04578.11 001197168.1_39722001_1 - 0.03 13.8 0.0 0.055 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF594 Trypsin PF00089.24 001195344.1_49822001_1 - 3.7e-67 226.3 1.2 4.2e-67 226.1 1.2 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001195344.1_49822001_1 - 8.7e-08 33.0 0.0 1.2e-07 32.6 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001195344.1_49822001_1 - 0.0019 18.4 0.7 0.0099 16.1 0.7 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Peptidase_M1 PF01433.18 001172979.1_09925001_1 - 5.3e-77 259.6 0.0 7.1e-77 259.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M1 Leuk-A4-hydro_C PF09127.9 001172979.1_09925001_1 - 4.8e-44 149.7 0.4 7.9e-44 149.0 0.4 1.4 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal E1_DerP2_DerF2 PF02221.13 001172979.1_09925001_1 - 0.031 14.6 0.1 0.062 13.6 0.1 1.5 1 0 0 1 1 1 0 ML domain DUF4367 PF14285.4 001172979.1_09925001_1 - 0.046 14.0 0.2 0.65 10.3 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4367) Peptidase_M48 PF01435.16 001172979.1_09925001_1 - 0.056 13.1 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M48 Hormone_3 PF00159.16 001160286.1_37922001_1 - 1.1e-18 66.9 1.4 1.1e-18 66.9 1.4 2.2 2 0 0 2 2 2 1 Pancreatic hormone peptide RNB PF00773.17 001195333.1_49827001_1 - 5.9e-101 337.9 0.0 8.1e-101 337.5 0.0 1.2 1 0 0 1 1 1 1 RNB domain Rrp44_CSD1 PF17216.1 001195333.1_49827001_1 - 1.5e-11 44.1 0.5 5.3e-10 39.1 0.0 2.7 2 1 1 3 3 3 1 Rrp44-like cold shock domain OB_RNB PF08206.9 001195333.1_49827001_1 - 0.032 13.8 0.0 0.087 12.4 0.0 1.8 1 0 0 1 1 1 0 Ribonuclease B OB domain Glyco_hydro_1 PF00232.16 001173119.1_09924001_3 - 1.5e-150 501.4 0.1 1.9e-150 501.1 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Cellulase PF00150.16 001173119.1_09924001_3 - 0.0063 15.8 0.0 0.022 14.1 0.0 1.8 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) PAR1 PF06521.9 001173119.1_09924001_3 - 0.093 12.2 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 PAR1 protein RsfS PF02410.13 029353.1_32922001_3 - 3.5e-26 91.3 0.0 4.5e-26 91.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation Motilin_ghrelin PF04644.10 001172860.1_09921001_2 - 7.9e-16 57.5 1.7 1.7e-15 56.4 1.7 1.6 1 0 0 1 1 1 1 Motilin/ghrelin Motilin_assoc PF04643.10 001172860.1_09921001_2 - 1.9e-10 40.3 0.0 3.2e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Motilin/ghrelin-associated peptide MRP-L28 PF09812.7 001172860.1_09921001_2 - 0.091 12.8 2.2 0.13 12.3 2.2 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 Cadherin PF00028.15 001163060.1_49829001_1 - 3e-80 264.7 11.5 8.8e-22 77.2 0.1 5.9 6 0 0 6 6 6 5 Cadherin domain Cadherin_C PF01049.15 001163060.1_49829001_1 - 1.4e-46 158.0 0.6 2.5e-46 157.1 0.6 1.4 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_pro PF08758.9 001163060.1_49829001_1 - 3.5e-30 103.9 0.0 9.6e-30 102.5 0.0 1.8 1 0 0 1 1 1 1 Cadherin prodomain like Cadherin_2 PF08266.10 001163060.1_49829001_1 - 0.0001 21.9 0.0 2.3 8.0 0.0 3.4 3 0 0 3 3 3 2 Cadherin-like Collagen PF01391.16 001195671.1_37929001_1 - 1.9e-172 559.0 737.4 2.3e-09 36.7 35.1 22.0 2 2 17 19 19 19 15 Collagen triple helix repeat (20 copies) COLFI PF01410.16 001195671.1_37929001_1 - 2.6e-113 376.9 0.1 3.4e-113 376.6 0.1 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain VWC PF00093.16 001195671.1_37929001_1 - 2e-11 43.9 14.9 2e-11 43.9 14.9 1.7 2 0 0 2 2 2 1 von Willebrand factor type C domain Mt_ATP-synt_D PF05873.10 001193447.1_49828001_2 - 0.0002 21.1 7.0 0.0002 21.1 7.0 4.8 4 2 2 6 6 6 1 ATP synthase D chain, mitochondrial (ATP5H) NAT PF04768.11 001193447.1_49828001_2 - 0.00051 19.6 0.7 0.22 11.0 0.0 3.5 3 0 0 3 3 3 2 NAT, N-acetyltransferase, of N-acetylglutamate synthase Invasin_D3 PF09134.8 001193447.1_49828001_2 - 0.062 12.9 0.0 0.38 10.4 0.0 2.2 2 0 0 2 2 2 0 Invasin, domain 3 GAS PF13851.4 001193447.1_49828001_2 - 5.8 6.1 120.9 0.068 12.4 19.5 6.0 1 1 5 6 6 6 0 Growth-arrest specific micro-tubule binding SOCS_box PF07525.14 001171090.1_37923001_1 - 0.03 14.6 0.8 0.12 12.6 0.8 2.1 1 0 0 1 1 1 0 SOCS box 7tm_1 PF00001.19 001171090.1_37923001_2 - 4.8e-54 183.2 18.5 1.3e-53 181.9 18.5 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171090.1_37923001_2 - 0.0033 16.7 14.8 0.0046 16.2 14.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TrbC PF04956.11 001171090.1_37923001_2 - 0.25 11.5 3.0 6.6 6.9 0.4 2.7 2 0 0 2 2 2 0 TrbC/VIRB2 family Sarcolipin PF05366.9 001171090.1_37923001_2 - 0.43 10.2 5.7 1.6 8.3 0.4 2.7 2 0 0 2 2 2 0 Sarcolipin DUF4713 PF15831.3 001171090.1_37923001_2 - 4.8 7.6 8.2 6.1 7.3 0.2 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4713) Hormone_2 PF00123.18 001195118.1_49822001_3 - 1.2e-13 50.6 0.1 2e-13 49.9 0.1 1.3 1 0 0 1 1 1 1 Peptide hormone Atg8 PF02991.14 001190288.1_49822001_2 - 1.3e-47 160.2 0.1 1.7e-47 159.8 0.1 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.11 001190288.1_49822001_2 - 2.7e-07 30.7 0.0 4.1e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 7tm_1 PF00001.19 001172964.1_09924001_2 - 6.9e-74 248.3 13.1 8.6e-74 248.0 13.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001172964.1_09924001_2 - 6.4e-08 32.1 11.5 1.2e-07 31.3 11.5 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001172964.1_09924001_2 - 5.5e-05 22.9 4.3 5.5e-05 22.9 4.3 1.8 1 1 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001172964.1_09924001_2 - 0.019 14.1 13.4 0.059 12.6 13.4 1.8 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx Hormone_1 PF00103.18 001197164.1_39722001_1 - 4.3e-62 209.5 0.0 4.8e-62 209.4 0.0 1.0 1 0 0 1 1 1 1 Somatotropin hormone family TAS2R PF05296.11 001166683.1_45722001_1 - 2.1e-73 247.0 42.9 2.4e-73 246.8 42.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) IL15 PF02372.13 001172829.1_09922001_1 - 2.6e-58 195.7 3.2 2.6e-58 195.7 3.2 1.8 2 0 0 2 2 2 1 Interleukin 15 Aminotran_1_2 PF00155.19 029391.1_49824120_1 - 1.1e-48 166.2 0.0 1.4e-48 165.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Preseq_ALAS PF09029.8 029391.1_49824120_1 - 4.7e-47 159.2 4.0 7.5e-47 158.5 4.0 1.3 1 0 0 1 1 1 1 5-aminolevulinate synthase presequence Aminotran_5 PF00266.17 029391.1_49824120_1 - 0.001 18.0 0.0 0.002 17.0 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.19 029391.1_49824120_2 - 3.3e-21 75.7 0.0 4.5e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Pkinase PF00069.23 001324552.1_32924001_1 - 2.3e-70 236.9 0.0 2.8e-70 236.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001324552.1_32924001_1 - 2.2e-43 148.3 0.0 2.9e-43 147.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001324552.1_32924001_1 - 5e-06 25.9 0.1 1.9e-05 24.0 0.0 1.9 2 1 0 2 2 2 1 Kinase-like RIO1 PF01163.20 001324552.1_32924001_1 - 0.00033 20.2 0.1 0.0006 19.3 0.1 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.12 001324552.1_32924001_1 - 0.002 17.4 0.1 0.0034 16.6 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.7 001324552.1_32924001_1 - 0.02 14.3 0.4 0.07 12.5 0.1 1.8 1 1 1 2 2 2 0 PhoP regulatory network protein YrbL zf-RING_2 PF13639.4 138580.1_32923120_1 - 4e-14 52.5 8.1 1.1e-13 51.0 8.1 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 138580.1_32923120_1 - 1.7e-10 40.4 8.4 6.2e-10 38.6 8.4 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 138580.1_32923120_1 - 5.4e-08 32.9 8.8 1.4e-07 31.5 8.8 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.3 138580.1_32923120_1 - 9.6e-08 31.5 8.9 1e-07 31.4 6.7 2.2 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.23 138580.1_32923120_1 - 1.4e-07 31.1 8.1 4.3e-07 29.6 8.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 138580.1_32923120_1 - 1.3e-06 28.1 5.8 3.9e-06 26.6 5.8 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.4 138580.1_32923120_1 - 9.4e-06 25.4 6.0 9.4e-06 25.4 6.0 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.5 138580.1_32923120_1 - 1.1e-05 25.2 2.1 2.3e-05 24.2 2.1 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.4 138580.1_32923120_1 - 1.2e-05 24.9 4.8 3e-05 23.6 4.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 138580.1_32923120_1 - 5.3e-05 22.8 8.1 0.00041 20.0 8.3 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 Rad50_zn_hook PF04423.12 138580.1_32923120_1 - 7.6e-05 22.3 2.0 0.1 12.3 0.2 2.9 3 0 0 3 3 3 2 Rad50 zinc hook motif zf-Nse PF11789.6 138580.1_32923120_1 - 0.0027 17.4 4.0 0.0047 16.6 4.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Zn_ribbon_17 PF17120.3 138580.1_32923120_1 - 0.0031 17.0 4.9 0.0082 15.6 4.9 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Prok-RING_1 PF14446.4 138580.1_32923120_1 - 0.04 13.7 3.4 2.7 7.9 0.4 2.5 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-RING_6 PF14835.4 138580.1_32923120_1 - 0.08 12.7 1.1 0.18 11.5 1.1 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein RINGv PF12906.5 138580.1_32923120_1 - 0.31 11.1 6.2 0.93 9.5 6.2 1.9 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.6 138580.1_32923120_1 - 0.44 10.6 4.2 1.8 8.7 4.2 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain rve PF00665.24 144501.1_32928120_1 - 0.025 14.7 0.0 0.039 14.0 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain RNase_H PF00075.22 144501.1_32928120_3 - 3.2e-06 27.3 0.0 5.6e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 RNase H Pkinase PF00069.23 144520.1_26224120_1 - 9.4e-24 84.0 0.0 1.2e-23 83.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 144520.1_26224120_1 - 0.013 14.7 0.0 0.21 10.7 0.0 2.0 2 0 0 2 2 2 0 Protein tyrosine kinase Pkinase PF00069.23 144520.1_26224120_3 - 2.3e-48 164.7 0.2 3e-48 164.3 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 144520.1_26224120_3 - 1.5e-27 96.4 0.1 2.1e-27 95.9 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.20 144520.1_26224120_3 - 0.0055 16.2 0.0 0.0082 15.6 0.0 1.1 1 0 0 1 1 1 1 RIO1 family Seadorna_VP7 PF07387.9 144520.1_26224120_3 - 0.034 13.1 0.0 0.052 12.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 UPF0547 PF10571.7 145834.1_26229120_1 - 2.2e-10 40.3 8.9 8.5e-10 38.4 8.9 2.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0547 CCDC24 PF15669.3 146064.1_26223120_1 - 1.7e-21 77.0 0.1 2.5e-21 76.4 0.1 1.2 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 24 family CCDC24 PF15669.3 146064.1_26223120_3 - 0.0018 18.0 0.2 0.0029 17.4 0.2 1.2 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 24 family RED_N PF07808.11 131103.1_32922120_2 - 0.16 11.5 0.1 0.21 11.1 0.1 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region Zona_pellucida PF00100.21 001281648.1_31324001_1 - 2.5e-54 184.5 0.2 1.2e-53 182.3 0.1 1.9 2 0 0 2 2 2 1 Zona pellucida-like domain Trefoil PF00088.16 001281648.1_31324001_1 - 1.1e-09 37.9 2.9 3.1e-09 36.4 2.9 1.9 1 0 0 1 1 1 1 Trefoil (P-type) domain TFIID-31kDa PF02291.13 001286112.1_31323001_1 - 1.5e-50 170.2 0.0 2.1e-50 169.7 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit AAA_18 PF13238.4 001286112.1_31323001_1 - 1.4e-07 32.0 0.2 2.9e-07 30.9 0.2 1.5 1 0 0 1 1 1 1 AAA domain CENP-S PF15630.4 001286112.1_31323001_1 - 3e-06 27.4 0.2 5.8e-06 26.5 0.2 1.4 1 0 0 1 1 1 1 CENP-S protein Bromo_TP PF07524.11 001286112.1_31323001_1 - 2.9e-05 23.9 0.0 5.4e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated AAA_28 PF13521.4 001286112.1_31323001_1 - 7.3e-05 22.9 0.0 0.00011 22.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.4 001286112.1_31323001_1 - 0.0001 22.6 0.1 0.0001 22.6 0.1 1.7 2 0 0 2 2 1 1 AAA domain AAA PF00004.27 001286112.1_31323001_1 - 0.00027 21.2 0.0 0.00049 20.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Histone PF00125.22 001286112.1_31323001_1 - 0.00089 19.5 0.2 0.0015 18.8 0.2 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.4 001286112.1_31323001_1 - 0.0026 17.7 0.1 0.0052 16.8 0.1 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold AAA_16 PF13191.4 001286112.1_31323001_1 - 0.0055 17.0 0.6 0.01 16.1 0.6 1.3 1 0 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.10 001286112.1_31323001_1 - 0.017 14.2 0.1 0.028 13.5 0.1 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.4 001286112.1_31323001_1 - 0.02 14.9 0.5 0.068 13.2 0.5 1.9 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.13 001286112.1_31323001_1 - 0.022 14.5 0.1 0.036 13.8 0.1 1.3 1 0 0 1 1 1 0 NTPase AAA_22 PF13401.4 001286112.1_31323001_1 - 0.027 14.6 0.1 0.053 13.6 0.1 1.4 1 0 0 1 1 1 0 AAA domain BDHCT_assoc PF16204.3 001286112.1_31323001_1 - 0.028 14.0 0.8 0.045 13.3 0.8 1.3 1 0 0 1 1 1 0 BDHCT-box associated domain on Bloom syndrome protein AAA_5 PF07728.12 001286112.1_31323001_1 - 0.029 14.2 0.1 0.061 13.2 0.1 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) SKI PF01202.20 001286112.1_31323001_1 - 0.036 14.1 0.0 0.065 13.2 0.0 1.4 1 0 0 1 1 1 0 Shikimate kinase ATPase PF06745.11 001286112.1_31323001_1 - 0.087 12.0 0.5 0.3 10.3 0.1 1.8 2 0 0 2 2 2 0 KaiC TsaE PF02367.15 001286112.1_31323001_1 - 0.11 12.4 0.2 0.2 11.6 0.2 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.4 001286112.1_31323001_1 - 0.11 12.1 0.2 0.18 11.4 0.2 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.4 001286112.1_31323001_1 - 0.13 11.9 0.4 0.29 10.7 0.4 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ADK PF00406.20 001286112.1_31323001_1 - 0.13 12.2 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Adenylate kinase AAA_32 PF13654.4 001286112.1_31323001_1 - 0.13 10.8 0.1 1.1 7.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain Zona_pellucida PF00100.21 001281552.1_31325001_2 - 6.1e-45 153.8 0.1 9.2e-45 153.2 0.1 1.3 1 0 0 1 1 1 1 Zona pellucida-like domain Trefoil PF00088.16 001281552.1_31325001_2 - 0.00012 21.7 7.4 0.00047 19.8 7.0 2.3 1 1 0 1 1 1 1 Trefoil (P-type) domain ODC_AZ PF02100.15 001301426.1_31322001_1 - 3e-15 56.1 0.0 4.4e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 001290483.1_31322001_1 - 2.8e-15 56.2 0.0 4e-15 55.7 0.0 1.1 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme 7tm_1 PF00001.19 001287611.1_31327001_1 - 7.5e-33 113.8 37.7 2e-31 109.1 37.7 2.2 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001287611.1_31327001_1 - 1.5e-10 41.2 23.2 1.3e-09 38.1 18.5 2.4 1 1 1 2 2 2 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001287611.1_31327001_1 - 4.9e-08 32.5 36.8 9e-08 31.7 36.8 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Zona_pellucida PF00100.21 001281671.1_31325001_1 - 4.6e-45 154.2 1.1 1.4e-42 146.1 0.1 2.3 2 0 0 2 2 2 2 Zona pellucida-like domain p450 PF00067.20 001281331.1_31324001_2 - 6.4e-148 493.2 0.0 7.6e-148 492.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 IL2 PF00715.15 001281629.1_31322001_3 - 7e-77 256.2 3.8 9.6e-77 255.7 3.8 1.1 1 0 0 1 1 1 1 Interleukin 2 Patched PF02460.16 001281376.1_31328001_1 - 1.1e-76 258.5 11.3 2e-45 155.1 0.0 2.1 2 0 0 2 2 2 2 Patched family NPC1_N PF16414.3 001281376.1_31328001_1 - 5e-72 242.3 7.5 5e-72 242.3 7.5 1.5 2 0 0 2 2 2 1 Niemann-Pick C1 N terminus Sterol-sensing PF12349.6 001281376.1_31328001_1 - 3.6e-53 179.4 0.6 3.6e-53 179.4 0.6 2.9 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.13 001281376.1_31328001_1 - 7.4e-08 31.6 0.9 7.4e-08 31.6 0.9 2.8 3 0 0 3 3 3 1 MMPL family Folate_rec PF03024.12 001281376.1_31328001_1 - 0.015 15.0 4.5 0.031 14.0 4.5 1.5 1 0 0 1 1 1 0 Folate receptor family ACR_tran PF00873.17 001281376.1_31328001_1 - 0.063 10.8 13.2 0.11 10.0 13.2 1.3 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family TMCCDC2 PF15844.3 001281376.1_31328001_1 - 6.4 6.5 6.8 11 5.8 0.0 3.4 3 0 0 3 3 3 0 Transmembrane and coiled-coil domain-containing protein 2 Spot_14 PF07084.10 001244376.1_49822001_1 - 5e-49 166.2 0.2 6.3e-49 165.9 0.2 1.1 1 0 0 1 1 1 1 Thyroid hormone-inducible hepatic protein Spot 14 Ada3 PF10198.7 001206536.1_49824001_1 - 3.3e-27 95.1 10.4 7.4e-26 90.7 10.5 2.5 2 0 0 2 2 2 1 Histone acetyltransferases subunit 3 YkyA PF10368.7 001206536.1_49824001_1 - 2.1 8.0 7.9 8.5 5.9 6.0 2.3 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein AdoHcyase PF05221.15 001201381.1_49829001_3 - 2.8e-120 400.8 0.0 4.9e-64 216.2 0.5 2.2 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.19 001201381.1_49829001_3 - 1.4e-81 272.1 2.5 2.3e-81 271.5 2.5 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.17 001201381.1_49829001_3 - 7.3e-09 35.1 0.1 1.5e-08 34.0 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.10 001201381.1_49829001_3 - 0.0002 20.9 0.0 0.00037 20.0 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain THF_DHG_CYH_C PF02882.17 001201381.1_49829001_3 - 0.001 18.3 1.2 0.0026 17.0 1.2 1.6 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.18 001201381.1_49829001_3 - 0.003 17.5 0.1 0.0068 16.3 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.19 001201381.1_49829001_3 - 0.0065 15.7 0.6 0.014 14.5 0.6 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.4 001201381.1_49829001_3 - 0.013 15.7 0.9 0.038 14.3 0.9 1.8 1 0 0 1 1 1 0 Putative NAD(P)-binding TrkA_N PF02254.16 001201381.1_49829001_3 - 0.027 14.6 0.2 0.063 13.4 0.2 1.6 1 1 0 1 1 1 0 TrkA-N domain Big_3_5 PF16640.3 001201381.1_49829001_3 - 0.086 12.9 0.1 0.2 11.7 0.1 1.6 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 3) Opiods_neuropep PF01160.16 001244476.1_49822001_3 - 1.3e-17 63.5 4.6 2.2e-17 62.7 4.6 1.4 1 0 0 1 1 1 1 Vertebrate endogenous opioids neuropeptide MDH PF02315.14 001244476.1_49822001_3 - 0.061 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Methanol dehydrogenase beta subunit 7tm_1 PF00001.19 001199792.1_39523001_1 - 1.5e-46 158.7 9.7 2e-46 158.2 9.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1856 PF08983.8 001199792.1_39523001_1 - 3.3e-21 75.2 6.8 6.4e-21 74.3 6.8 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1856) 7TM_GPCR_Srsx PF10320.7 001199792.1_39523001_1 - 3.8e-07 29.6 6.3 6e-07 29.0 6.3 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 001199792.1_39523001_1 - 5.1e-07 29.2 0.3 8.5e-07 28.5 0.2 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 001199792.1_39523001_1 - 1.4e-06 28.2 2.4 2.4e-06 27.4 2.4 1.4 1 0 0 1 1 1 1 Olfactory receptor Trefoil PF00088.16 001243483.1_49822001_3 - 4.8e-15 55.0 9.1 4.8e-15 55.0 9.1 1.9 2 0 0 2 2 2 1 Trefoil (P-type) domain 7tm_1 PF00001.19 214130.2_49825001_1 - 9.4e-42 143.0 18.7 1.8e-41 142.1 18.7 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 214130.2_49825001_1 - 3.2e-08 32.9 16.6 4.7e-08 32.4 16.6 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7TM_GPCR_Srx PF10328.7 214130.2_49825001_1 - 0.028 13.6 18.0 0.035 13.3 13.3 2.3 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx Sigma_reg_N PF13800.4 214130.2_49825001_1 - 0.04 14.1 0.8 0.14 12.3 0.2 2.3 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF3012 PF11216.6 214130.2_49825001_1 - 0.91 9.5 4.9 1 9.3 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3012) Transferrin PF00405.15 001244653.1_49825001_1 - 2.1e-264 875.0 15.1 1.5e-180 599.4 0.8 2.0 2 0 0 2 2 2 2 Transferrin Phosphonate-bd PF12974.5 001244653.1_49825001_1 - 1.9e-11 43.9 0.0 0.00025 20.6 0.0 2.7 3 0 0 3 3 3 2 ABC transporter, phosphonate, periplasmic substrate-binding protein Homeobox PF00046.27 001244370.1_49822001_1 - 2e-22 78.6 8.4 3e-22 78.1 8.4 1.3 1 0 0 1 1 1 1 Homeobox domain OAR PF03826.15 001244370.1_49822001_1 - 2e-07 30.5 1.3 3.7e-07 29.6 1.3 1.5 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.9 001244370.1_49822001_1 - 0.011 15.5 0.4 0.011 15.5 0.4 1.9 2 0 0 2 2 2 0 Homeobox KN domain Forkhead_N PF08430.10 001244370.1_49822001_1 - 0.47 10.9 16.7 1 9.9 16.7 1.6 1 0 0 1 1 1 0 Forkhead N-terminal region zf-H2C2_2 PF13465.4 001244660.1_49828001_1 - 1.1e-48 161.4 93.2 1.5e-08 34.5 0.7 11.5 11 0 0 11 11 11 9 Zinc-finger double domain zf-C2H2 PF00096.24 001244660.1_49828001_1 - 1.9e-31 106.6 102.1 0.00014 22.0 1.1 11.7 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001244660.1_49828001_1 - 5.8e-24 82.6 96.5 0.0082 16.8 2.7 11.7 11 0 0 11 11 11 10 C2H2-type zinc finger zf-H2C2_5 PF13909.4 001244660.1_49828001_1 - 2.4e-16 59.0 81.0 1.7e-06 27.6 0.6 10.4 10 0 0 10 10 10 6 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.6 001244660.1_49828001_1 - 2.6e-07 30.6 58.3 0.037 14.2 0.2 11.2 9 1 2 11 11 11 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 001244660.1_49828001_1 - 0.012 15.9 2.5 0.012 15.9 2.5 9.8 11 0 0 11 11 11 0 Zinc-finger of C2H2 type Methyltransf_25 PF13649.4 001110419.2_49823001_2 - 1.1e-11 45.2 0.0 2e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 001110419.2_49823001_2 - 1.3e-10 41.2 0.0 2e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001110419.2_49823001_2 - 9.8e-09 35.7 0.0 1.7e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 001110419.2_49823001_2 - 2.1e-08 34.1 0.0 2.9e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001110419.2_49823001_2 - 3.9e-08 33.7 0.0 7.2e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.12 001110419.2_49823001_2 - 0.00042 19.6 0.0 0.0036 16.6 0.0 2.1 2 0 0 2 2 2 1 Tellurite resistance protein TehB Ubie_methyltran PF01209.16 001110419.2_49823001_2 - 0.005 16.1 0.0 0.0083 15.3 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.12 001110419.2_49823001_2 - 0.012 15.1 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.17 001110419.2_49823001_2 - 0.1 12.2 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TPMT PF05724.9 001110419.2_49823001_2 - 0.12 11.8 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) NRN1 PF15056.4 001243601.1_49824001_1 - 1.4e-37 127.5 1.1 2e-37 127.0 1.1 1.2 1 0 0 1 1 1 1 Neuritin protein family HSP70 PF00012.18 001243907.1_49825001_1 - 8.6e-264 876.1 12.7 9.8e-264 875.9 12.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 001243907.1_49825001_1 - 1.8e-18 66.3 0.3 4.9e-17 61.6 0.1 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.4 001243907.1_49825001_1 - 0.0006 20.1 2.3 1.6 9.0 0.0 3.5 3 1 0 3 3 3 2 Cell division protein FtsA FGGY_C PF02782.14 001243907.1_49825001_1 - 0.0022 17.6 0.0 0.0057 16.3 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.18 001243907.1_49825001_1 - 0.017 14.5 0.1 5.6 6.3 0.0 2.4 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family DDR PF08841.8 001243907.1_49825001_1 - 0.044 12.6 0.4 0.2 10.5 0.3 1.9 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain HORMA PF02301.16 001243907.1_49825001_1 - 0.083 12.3 1.3 0.19 11.1 1.3 1.6 1 0 0 1 1 1 0 HORMA domain Radial_spoke_3 PF06098.9 001243907.1_49825001_1 - 0.14 11.3 8.3 0.28 10.3 8.3 1.4 1 0 0 1 1 1 0 Radial spoke protein 3 p450 PF00067.20 001243304.1_49826001_3 - 6.3e-106 354.7 0.0 7.3e-106 354.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Acyl-CoA_dh_1 PF00441.22 001243574.1_49824001_1 - 1.9e-43 148.1 1.3 2.7e-43 147.6 1.3 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.17 001243574.1_49824001_1 - 3.7e-27 94.2 0.0 6.9e-27 93.4 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.14 001243574.1_49824001_1 - 1.3e-26 93.3 0.0 2.6e-26 92.3 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.9 001243574.1_49824001_1 - 7.1e-19 68.3 0.3 1.1e-18 67.7 0.3 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Cir_N PF10197.7 027203.3_32925001_1 - 1.2e-06 28.4 8.9 1.2e-06 28.4 8.9 4.4 5 1 0 5 5 5 1 N-terminal domain of CBF1 interacting co-repressor CIR TMEM169 PF15052.4 175564.4_32926001_2 - 2.7e-61 205.3 8.2 2.7e-61 205.3 8.2 1.9 2 0 0 2 2 2 1 TMEM169 protein family Dysbindin PF04440.14 001170975.2_32924001_1 - 1.5e-09 38.1 0.1 0.00026 21.0 0.0 2.2 1 1 1 2 2 2 2 Dysbindin (Dystrobrevin binding protein 1) DUF4078 PF13300.4 001244302.1_49823001_3 - 6.1e-28 96.8 13.5 6.1e-28 96.8 13.5 3.6 3 0 0 3 3 3 1 Domain of unknown function (DUF4078) Hormone_3 PF00159.16 001244302.1_49823001_3 - 0.037 14.0 0.1 3.5 7.7 0.0 2.6 2 0 0 2 2 2 0 Pancreatic hormone peptide 5_3_exonuc PF01367.18 001244302.1_49823001_3 - 1.3 9.5 7.7 3.2 8.3 0.2 2.7 2 0 0 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold TAS2R PF05296.11 001080757.2_29622001_1 - 4.6e-82 275.4 39.6 5.2e-82 275.2 39.6 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) RE_HpaII PF09561.8 001080757.2_29622001_1 - 0.011 15.0 0.1 0.018 14.3 0.1 1.3 1 0 0 1 1 1 0 HpaII restriction endonuclease PAG PF15347.4 001080757.2_29622001_1 - 1.7 7.4 4.6 0.54 9.1 1.9 1.4 1 1 1 2 2 2 0 Phosphoprotein associated with glycosphingolipid-enriched CRAL_TRIO PF00650.18 001198918.1_49823001_1 - 2e-41 141.2 0.0 3e-41 140.6 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain GOLD_2 PF13897.4 001198918.1_49823001_1 - 1.1e-07 32.3 0.2 0.0011 19.3 0.0 2.5 1 1 1 2 2 2 2 Golgi-dynamics membrane-trafficking CRAL_TRIO_2 PF13716.4 001198918.1_49823001_1 - 6.4e-05 22.9 0.0 0.00011 22.2 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Pkinase PF00069.23 001256146.1_49823001_3 - 1.1e-77 260.8 0.1 2.3e-77 259.8 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 001256146.1_49823001_3 - 2.1e-36 125.4 0.0 2.9e-36 125.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.27 001256146.1_49823001_3 - 5.6e-15 55.6 0.4 1.4e-14 54.4 0.1 1.8 2 0 0 2 2 2 1 PH domain Pkinase_C PF00433.22 001256146.1_49823001_3 - 2e-09 37.8 2.6 4.2e-09 36.8 2.6 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 001256146.1_49823001_3 - 1.3e-08 34.4 0.0 3.4e-08 33.0 0.0 1.7 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.4 001256146.1_49823001_3 - 0.0098 15.4 0.4 1.1 8.8 0.1 2.3 1 1 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 PH_11 PF15413.4 001256146.1_49823001_3 - 0.04 14.2 0.5 0.27 11.5 0.5 2.4 2 1 0 2 2 2 0 Pleckstrin homology domain APH PF01636.21 001256146.1_49823001_3 - 0.19 11.4 0.4 0.37 10.5 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family CIDE-N PF02017.13 001112688.1_49822001_2 - 4.2e-25 87.4 0.2 6.9e-25 86.7 0.2 1.4 1 0 0 1 1 1 1 CIDE-N domain CIMR PF00878.16 001244473.1_49829001_2 - 0 1299.1 67.2 8e-53 178.2 0.0 16.2 16 0 0 16 16 16 16 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.8 001244473.1_49829001_2 - 4.7e-63 213.4 60.4 2e-08 34.3 0.1 16.3 3 2 10 13 13 13 13 Autophagy-related protein 27 fn2 PF00040.17 001244473.1_49829001_2 - 1.8e-16 60.0 2.3 1.8e-16 60.0 2.3 2.6 3 0 0 3 3 3 1 Fibronectin type II domain Man-6-P_recep PF02157.13 001244473.1_49829001_2 - 8.9e-10 38.2 5.1 0.00035 19.8 0.2 5.3 4 0 0 4 4 4 3 Mannose-6-phosphate receptor PRKCSH_1 PF13015.4 001244473.1_49829001_2 - 1.7e-07 30.9 33.2 0.15 11.6 0.1 10.9 12 0 0 12 12 12 4 Glucosidase II beta subunit-like protein AAA PF00004.27 040116.1_26228120_2 - 3.8e-57 192.3 0.0 2.3e-41 141.2 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_2 PF02933.15 040116.1_26228120_2 - 5.9e-11 41.9 0.9 3.2e-10 39.5 0.1 2.4 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_22 PF13401.4 040116.1_26228120_2 - 1.2e-08 35.2 0.2 0.0047 17.1 0.1 4.1 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.4 040116.1_26228120_2 - 2.2e-08 34.5 0.0 0.0013 19.0 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain RNA_helicase PF00910.20 040116.1_26228120_2 - 3.4e-07 30.5 0.0 0.026 14.8 0.0 3.1 2 0 0 2 2 2 2 RNA helicase RuvB_N PF05496.10 040116.1_26228120_2 - 3.6e-07 29.6 0.0 0.017 14.2 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.12 040116.1_26228120_2 - 3.8e-07 30.2 0.0 2.2e-05 24.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.4 040116.1_26228120_2 - 2.3e-06 27.7 0.0 0.058 13.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.12 040116.1_26228120_2 - 3.1e-06 27.1 0.0 0.0014 18.5 0.0 2.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.4 040116.1_26228120_2 - 3.5e-06 27.0 0.0 0.048 13.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.4 040116.1_26228120_2 - 4.5e-06 27.1 0.0 0.02 15.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.11 040116.1_26228120_2 - 8.4e-06 24.8 0.0 0.079 11.8 0.0 2.2 2 0 0 2 2 2 2 TIP49 C-terminus Mg_chelatase PF01078.19 040116.1_26228120_2 - 2.9e-05 23.4 0.1 0.0053 16.0 0.1 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI TsaE PF02367.15 040116.1_26228120_2 - 8.7e-05 22.4 0.0 0.056 13.3 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.4 040116.1_26228120_2 - 9.3e-05 22.1 0.0 0.15 11.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain NACHT PF05729.10 040116.1_26228120_2 - 0.00016 21.5 0.0 0.28 10.9 0.0 3.2 3 1 0 3 3 2 1 NACHT domain ATPase_2 PF01637.16 040116.1_26228120_2 - 0.00016 21.5 0.1 0.12 12.1 0.1 3.6 2 2 2 4 4 4 1 ATPase domain predominantly from Archaea ABC_tran PF00005.25 040116.1_26228120_2 - 0.0026 18.1 0.0 0.0084 16.5 0.0 1.8 2 0 0 2 2 1 1 ABC transporter AAA_28 PF13521.4 040116.1_26228120_2 - 0.0027 17.8 0.0 0.16 12.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.4 040116.1_26228120_2 - 0.0027 18.0 0.0 3.1 8.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.10 040116.1_26228120_2 - 0.0092 15.2 0.0 3 7.0 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin IstB_IS21 PF01695.15 040116.1_26228120_2 - 0.0095 15.6 0.0 0.22 11.1 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein ATPase PF06745.11 040116.1_26228120_2 - 0.01 15.0 0.1 0.08 12.1 0.0 2.3 2 1 1 3 3 3 0 KaiC AAA_3 PF07726.9 040116.1_26228120_2 - 0.014 15.1 0.0 0.95 9.2 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.20 040116.1_26228120_2 - 0.019 13.9 0.0 0.25 10.2 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain Sigma54_activat PF00158.24 040116.1_26228120_2 - 0.02 14.5 0.0 3 7.4 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_25 PF13481.4 040116.1_26228120_2 - 0.03 13.8 0.2 2.1 7.8 0.0 2.9 3 0 0 3 3 3 0 AAA domain Parvo_NS1 PF01057.15 040116.1_26228120_2 - 0.03 13.3 0.1 3.1 6.7 0.0 2.9 4 0 0 4 4 4 0 Parvovirus non-structural protein NS1 KTI12 PF08433.8 040116.1_26228120_2 - 0.034 13.4 0.1 12 5.1 0.0 3.0 3 0 0 3 3 3 0 Chromatin associated protein KTI12 AAA_11 PF13086.4 040116.1_26228120_2 - 0.063 12.9 0.0 3.3 7.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain CDC48_N PF02359.16 040116.1_26228120_3 - 0.15 12.1 0.0 0.24 11.5 0.0 1.2 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), N-terminal domain Brix PF04427.16 001266231.1_29623001_2 - 8.7e-30 104.1 0.0 1.2e-29 103.7 0.0 1.2 1 0 0 1 1 1 1 Brix domain Ran-binding PF05508.9 001266231.1_29623001_2 - 0.1 11.4 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 RanGTP-binding protein DUF2415 PF10313.7 001266231.1_29623001_2 - 0.12 12.2 0.0 0.26 11.1 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein domain (DUF2415) Cwf_Cwc_15 PF04889.10 001266231.1_29623001_2 - 1.2 8.6 5.5 1.8 8.1 5.5 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Tropomyosin PF00261.18 001126351.1_39522001_1 - 4.2e-102 340.4 86.0 1e-97 326.1 61.2 2.0 1 1 1 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.5 001126351.1_39522001_1 - 9.6e-42 142.4 71.5 2.8e-37 127.9 41.1 3.1 2 1 0 2 2 2 2 Tropomyosin like CLZ PF16526.3 001126351.1_39522001_1 - 1.8e-06 28.1 49.0 4e-05 23.7 11.3 4.9 1 1 3 5 5 5 3 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Laminin_II PF06009.10 001126351.1_39522001_1 - 2.6e-06 27.4 37.8 5.9e-05 23.0 6.5 4.0 1 1 3 4 4 4 3 Laminin Domain II IncA PF04156.12 001126351.1_39522001_1 - 0.00025 20.8 60.8 0.0007 19.3 25.0 2.9 1 1 2 3 3 3 1 IncA protein TMF_DNA_bd PF12329.6 001126351.1_39522001_1 - 0.00035 20.4 18.6 0.00092 19.0 9.8 6.4 1 1 4 6 6 6 3 TATA element modulatory factor 1 DNA binding AAA_13 PF13166.4 001126351.1_39522001_1 - 0.0035 16.0 47.4 0.16 10.4 28.1 2.1 1 1 1 2 2 2 2 AAA domain DUF745 PF05335.11 001126351.1_39522001_1 - 0.0047 16.6 47.8 0.14 11.8 8.4 3.2 1 1 2 3 3 3 3 Protein of unknown function (DUF745) CENP-F_leu_zip PF10473.7 001126351.1_39522001_1 - 0.0065 16.4 28.9 0.0065 16.4 28.9 2.4 2 0 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Laminin_I PF06008.12 001126351.1_39522001_1 - 0.0072 15.9 53.3 0.051 13.1 17.1 3.2 1 1 2 3 3 3 2 Laminin Domain I DUF1664 PF07889.10 001126351.1_39522001_1 - 0.0077 16.1 30.1 0.058 13.2 2.8 3.9 1 1 4 5 5 5 2 Protein of unknown function (DUF1664) DUF3450 PF11932.6 001126351.1_39522001_1 - 0.008 15.4 8.6 0.008 15.4 8.6 3.4 1 1 2 3 3 2 1 Protein of unknown function (DUF3450) ERM PF00769.17 001126351.1_39522001_1 - 0.016 15.0 70.8 0.23 11.1 23.1 3.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family XhlA PF10779.7 001126351.1_39522001_1 - 0.016 15.2 2.4 0.016 15.2 2.4 6.6 2 2 6 8 8 8 0 Haemolysin XhlA DUF16 PF01519.14 001126351.1_39522001_1 - 0.045 14.1 37.7 0.39 11.1 0.3 4.3 1 1 3 4 4 4 0 Protein of unknown function DUF16 ATG16 PF08614.9 001126351.1_39522001_1 - 0.046 13.8 60.8 0.22 11.6 22.0 3.3 1 1 1 2 2 1 0 Autophagy protein 16 (ATG16) MscS_porin PF12795.5 001126351.1_39522001_1 - 0.05 13.0 49.3 1.4 8.3 29.5 2.9 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Golgin_A5 PF09787.7 001126351.1_39522001_1 - 0.052 12.9 53.9 1.1 8.6 21.0 2.7 1 1 2 3 3 3 0 Golgin subfamily A member 5 Alanine_zipper PF11839.6 001126351.1_39522001_1 - 0.095 12.9 48.3 0.053 13.7 2.5 4.9 1 1 2 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein ADIP PF11559.6 001126351.1_39522001_1 - 0.11 12.4 49.3 2.6 8.0 9.4 4.1 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding Reo_sigmaC PF04582.10 001126351.1_39522001_1 - 0.31 10.3 9.8 0.85 8.8 1.0 2.2 2 0 0 2 2 2 0 Reovirus sigma C capsid protein SlyX PF04102.10 001126351.1_39522001_1 - 0.5 10.9 45.1 0.66 10.5 0.4 5.4 1 1 5 6 6 6 0 SlyX DUF3584 PF12128.6 001126351.1_39522001_1 - 0.52 7.6 57.2 0.86 6.9 24.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) EzrA PF06160.10 001126351.1_39522001_1 - 0.78 7.7 53.8 0.2 9.7 8.6 3.1 1 1 2 3 3 3 0 Septation ring formation regulator, EzrA MAD PF05557.11 001126351.1_39522001_1 - 0.85 7.7 58.6 1.1 7.4 26.4 2.0 1 1 1 2 2 2 0 Mitotic checkpoint protein DUF1794 PF08768.9 001126351.1_39522001_1 - 0.86 9.4 4.2 14 5.5 0.3 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1794) DUF4472 PF14739.4 001126351.1_39522001_1 - 0.86 10.2 51.2 0.68 10.6 9.7 4.6 1 1 4 5 5 4 0 Domain of unknown function (DUF4472) GAS PF13851.4 001126351.1_39522001_1 - 0.96 8.6 61.3 0.9 8.7 15.8 2.9 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Exonuc_VII_L PF02601.13 001126351.1_39522001_1 - 1.1 8.6 35.2 1.6e+04 -7.8 35.2 2.3 1 1 0 1 1 0 0 Exonuclease VII, large subunit NPV_P10 PF05531.10 001126351.1_39522001_1 - 1.2 9.6 20.3 13 6.2 2.4 4.5 2 2 2 4 4 4 0 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.8 001126351.1_39522001_1 - 1.3 9.1 32.9 0.12 12.4 7.0 3.4 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family FH2 PF02181.21 001126351.1_39522001_1 - 1.5 7.7 37.4 0.46 9.4 9.0 3.2 1 1 2 3 3 3 0 Formin Homology 2 Domain Fmp27_WPPW PF10359.7 001126351.1_39522001_1 - 1.5 7.4 38.5 0.33 9.6 9.3 2.8 1 1 2 3 3 3 0 RNA pol II promoter Fmp27 protein domain Lebercilin PF15619.4 001126351.1_39522001_1 - 1.7 8.1 63.0 0.51 9.8 18.8 3.2 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease APG6 PF04111.10 001126351.1_39522001_1 - 2.1 7.5 64.4 0.25 10.5 20.7 3.1 1 1 2 3 3 3 0 Autophagy protein Apg6 HOOK PF05622.10 001126351.1_39522001_1 - 2.6 5.9 57.3 0.038 12.0 15.0 2.1 1 1 0 2 2 2 0 HOOK protein SNARE PF05739.17 001126351.1_39522001_1 - 3.5 7.6 12.4 1.5 8.7 0.1 4.5 5 0 0 5 5 4 0 SNARE domain Fez1 PF06818.13 001126351.1_39522001_1 - 5.7 7.2 52.5 1 9.6 13.4 3.2 1 1 1 2 2 1 0 Fez1 FPP PF05911.9 001126351.1_39522001_1 - 5.9 4.9 59.0 0.42 8.7 17.8 2.8 1 1 2 3 3 3 0 Filament-like plant protein, long coiled-coil Spc7 PF08317.9 001126351.1_39522001_1 - 9.8 4.8 64.7 0.67 8.6 27.9 2.8 1 1 2 3 3 3 0 Spc7 kinetochore protein Erg28 PF03694.11 001167637.1_49821001_1 - 2e-37 127.8 1.5 2.4e-37 127.6 1.5 1.0 1 0 0 1 1 1 1 Erg28 like protein LRR_6 PF13516.4 001246608.1_39724001_1 - 0.048 13.6 2.1 7 6.9 0.0 3.9 4 0 0 4 4 4 0 Leucine Rich repeat LRR_4 PF12799.5 001246608.1_39724001_1 - 0.055 13.8 0.9 3 8.2 0.1 2.6 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001246608.1_39724001_1 - 5.5 7.7 7.3 37 5.2 0.1 4.2 4 0 0 4 4 4 0 Leucine Rich Repeat Hormone_6 PF00236.16 001285684.1_09021001_1 - 1.7e-53 178.4 11.6 2e-53 178.2 11.6 1.1 1 0 0 1 1 1 1 Glycoprotein hormone PDGF PF00341.15 001285684.1_09021001_1 - 0.22 11.7 9.4 0.37 11.0 9.4 1.4 1 1 0 1 1 1 0 PDGF/VEGF domain DUF1218 PF06749.10 001285684.1_09021001_1 - 6.7 7.2 8.1 0.92 9.9 2.6 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1218) AIG1 PF04548.14 001286629.1_32927001_1 - 5.4e-54 182.6 0.0 8e-54 182.0 0.0 1.2 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.21 001286629.1_32927001_1 - 3.9e-06 26.8 0.0 6.1e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.14 001286629.1_32927001_2 - 1.2e-71 240.3 2.5 2.2e-65 219.8 0.4 2.1 2 0 0 2 2 2 2 AIG1 family MMR_HSR1 PF01926.21 001286629.1_32927001_2 - 2e-06 27.7 0.0 3.3e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001286629.1_32927001_2 - 0.00076 19.3 0.4 0.0015 18.4 0.1 1.6 2 0 0 2 2 2 1 Protein of unknown function, DUF258 SCF PF02404.13 001285670.1_09029001_2 - 1.4e-148 493.4 4.0 1.8e-148 493.1 4.0 1.1 1 0 0 1 1 1 1 Stem cell factor RhoGEF PF00621.18 001267833.1_49826001_2 - 1.3e-41 142.8 5.8 3.3e-41 141.4 5.8 1.8 1 0 0 1 1 1 1 RhoGEF domain SH3_1 PF00018.26 001267833.1_49826001_2 - 4.1e-26 90.2 2.0 2.2e-16 59.0 0.1 2.5 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.15 001267833.1_49826001_2 - 3.9e-24 84.0 0.4 4.9e-14 51.6 0.1 2.6 2 0 0 2 2 2 2 Variant SH3 domain CAMSAP_CH PF11971.6 001267833.1_49826001_2 - 8.5e-21 73.5 0.1 2.5e-20 71.9 0.1 1.9 1 0 0 1 1 1 1 CAMSAP CH domain CH PF00307.29 001267833.1_49826001_2 - 3.5e-20 72.1 1.0 1.8e-19 69.8 0.1 2.4 2 0 0 2 2 2 1 Calponin homology (CH) domain SH3_9 PF14604.4 001267833.1_49826001_2 - 4.7e-19 67.9 0.7 2.4e-12 46.3 0.1 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH2 PF00017.22 001267833.1_49826001_2 - 2e-17 62.9 0.0 5.3e-17 61.5 0.0 1.8 1 0 0 1 1 1 1 SH2 domain C1_1 PF00130.20 001267833.1_49826001_2 - 3.4e-11 42.7 4.2 7.6e-11 41.6 4.2 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PH PF00169.27 001267833.1_49826001_2 - 2.2e-09 37.6 0.2 5e-09 36.5 0.2 1.6 1 0 0 1 1 1 1 PH domain CDC24 PF06395.9 001267833.1_49826001_2 - 4.6e-05 23.5 0.2 0.00024 21.2 0.1 2.2 2 0 0 2 2 1 1 CDC24 Calponin C1_2 PF03107.14 001267833.1_49826001_2 - 0.0017 18.5 3.1 0.0041 17.3 3.1 1.7 1 0 0 1 1 1 1 C1 domain DUF3104 PF11302.6 001267833.1_49826001_2 - 0.019 14.6 0.8 4.2 7.0 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3104) DUF4335 PF14233.4 001267833.1_49826001_2 - 0.11 12.3 0.5 0.23 11.2 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4335) Prok-RING_1 PF14446.4 001267833.1_49826001_2 - 0.6 9.9 4.4 3.1 7.6 4.1 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 AJAP1_PANP_C PF15298.4 001285409.1_29525001_3 - 1.1e-07 32.1 0.0 2.8e-07 30.8 0.0 1.5 2 0 0 2 2 2 1 AJAP1/PANP C-terminus IFN-gamma PF00714.15 001285682.1_09022001_1 - 8.4e-70 232.9 2.9 1e-69 232.6 2.9 1.0 1 0 0 1 1 1 1 Interferon gamma API5 PF05918.9 001285682.1_09022001_1 - 8.1e-05 21.5 0.6 8.1e-05 21.5 0.6 1.8 1 1 1 2 2 2 1 Apoptosis inhibitory protein 5 (API5) DnaGprimase_HBD PF16730.3 001285682.1_09022001_1 - 0.03 14.3 2.2 0.047 13.6 1.6 1.5 1 1 0 1 1 1 0 DnaG-primase C-terminal, helicase-binding domain PRANC PF09372.8 001285682.1_09022001_1 - 0.037 14.2 1.0 0.058 13.6 0.7 1.4 1 1 0 1 1 1 0 PRANC domain Cep57_MT_bd PF06657.11 001285682.1_09022001_1 - 0.082 13.2 0.2 0.21 11.9 0.2 1.7 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Pro_isomerase PF00160.19 001278847.1_22422001_1 - 2.6e-50 170.6 0.2 3.2e-50 170.4 0.2 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 7tm_1 PF00001.19 001285723.1_09024001_2 - 1.3e-52 178.5 9.8 3.7e-52 177.1 9.8 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001285723.1_09024001_2 - 0.0011 18.3 4.8 0.0015 17.8 4.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Ctr PF04145.13 001285723.1_09024001_2 - 0.022 15.2 0.0 0.091 13.3 0.1 2.0 2 0 0 2 2 2 0 Ctr copper transporter family TAS2R PF05296.11 001285723.1_09024001_2 - 0.073 12.0 4.0 0.045 12.7 0.4 2.0 2 0 0 2 2 2 0 Taste receptor protein (TAS2R) FAM70 PF14967.4 001289727.1_32924001_1 - 1.3e-137 458.6 4.3 1.7e-137 458.2 4.3 1.0 1 0 0 1 1 1 1 FAM70 protein DUF4064 PF13273.4 001289727.1_32924001_1 - 0.0025 18.0 10.8 0.036 14.3 6.4 2.6 2 1 0 2 2 2 2 Protein of unknown function (DUF4064) Phage_holin_3_2 PF04550.10 001289727.1_32924001_1 - 0.031 14.5 1.2 0.031 14.5 1.2 1.8 2 0 0 2 2 2 0 Phage holin family 2 PPARgamma_N PF12577.6 001285658.1_09024001_3 - 5.3e-32 110.2 1.1 1.3e-31 108.9 1.1 1.7 1 0 0 1 1 1 1 PPAR gamma N-terminal region zf-C4 PF00105.16 001285658.1_09024001_3 - 1.8e-27 95.5 15.0 2.8e-27 94.8 15.0 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001285658.1_09024001_3 - 3.9e-16 59.1 0.1 1.2e-15 57.5 0.1 1.7 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Tmemb_55A PF09788.7 001285658.1_09024001_3 - 0.022 13.7 3.3 0.035 13.1 3.3 1.2 1 0 0 1 1 1 0 Transmembrane protein 55A INSIG PF07281.10 001286088.1_09023001_1 - 7e-47 159.7 8.0 3.8e-46 157.3 8.0 2.0 1 1 0 1 1 1 1 Insulin-induced protein (INSIG) SLAC1 PF03595.15 001286088.1_09023001_1 - 0.078 12.2 7.3 0.19 10.9 7.3 1.6 1 1 0 1 1 1 0 Voltage-dependent anion channel DUF202 PF02656.13 001286088.1_09023001_1 - 0.59 10.5 6.3 1.4 9.3 1.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF202) Histone PF00125.22 001287416.1_49823001_1 - 2.6e-54 183.0 2.1 5e-54 182.1 2.1 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.4 001287416.1_49823001_1 - 0.00053 20.2 0.0 0.00084 19.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.4 001287416.1_49823001_1 - 0.001 19.0 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.21 001287416.1_49823001_1 - 0.0064 16.6 0.1 0.011 15.9 0.1 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Glyco_transf_6 PF03414.11 001267732.1_08025001_1 - 5.9e-160 531.2 4.7 7.3e-160 530.9 4.7 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 6 Cys_knot PF00007.20 001285644.1_09022001_2 - 1.2e-33 115.4 16.7 1.2e-33 115.4 16.7 1.6 2 0 0 2 2 2 1 Cystine-knot domain MIF4G PF02854.17 001082379.2_37928001_1 - 1.9e-57 194.2 2.3 1.9e-57 194.2 2.3 1.9 2 0 0 2 2 2 1 MIF4G domain W2 PF02020.16 001082379.2_37928001_1 - 2.3e-20 72.4 1.1 7.1e-20 70.8 1.1 1.9 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon MA3 PF02847.15 001082379.2_37928001_1 - 3.3e-17 62.3 0.2 3.3e-17 62.3 0.2 2.8 3 0 0 3 3 3 1 MA3 domain Casein_kappa PF00997.16 001285587.1_09022001_3 - 9.4e-74 246.7 14.6 1.2e-73 246.4 14.6 1.1 1 0 0 1 1 1 1 Kappa casein IL34 PF15036.4 001285975.1_49822001_1 - 2.5e-73 245.2 0.3 3e-73 244.9 0.3 1.0 1 0 0 1 1 1 1 Interleukin 34 UQ_con PF00179.24 001284878.1_29525001_3 - 5.2e-47 158.9 0.0 7e-47 158.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.4 001284878.1_29525001_3 - 0.0086 15.6 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.11 001284878.1_29525001_3 - 0.013 15.2 0.0 0.022 14.5 0.0 1.3 1 0 0 1 1 1 0 UEV domain TNFR_c6 PF00020.16 001267730.1_08022001_2 - 7.2e-12 45.4 41.3 0.00023 21.4 0.7 4.7 5 0 0 5 5 5 4 TNFR/NGFR cysteine-rich region TMEM154 PF15102.4 001267730.1_08022001_2 - 0.19 11.5 0.0 0.27 11.0 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family Cys_knot PF00007.20 001283861.1_29521001_1 - 1.1e-32 112.3 5.4 1.3e-32 112.1 5.4 1.0 1 0 0 1 1 1 1 Cystine-knot domain IL1 PF00340.17 001283539.1_29522001_3 - 4.6e-39 132.7 0.0 5.7e-39 132.4 0.0 1.1 1 0 0 1 1 1 1 Interleukin-1 / 18 COesterase PF00135.26 001283294.1_29524001_2 - 3e-164 547.6 0.0 3.4e-164 547.4 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 001283294.1_29524001_2 - 1.4e-10 41.2 1.6 7.1e-10 39.0 1.6 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.7 001283294.1_29524001_2 - 0.012 14.4 0.0 0.037 12.7 0.0 1.7 1 1 0 1 1 1 0 Steryl acetyl hydrolase Peptidase_S9 PF00326.19 001283294.1_29524001_2 - 0.024 14.0 0.1 0.047 13.0 0.1 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family Esterase PF00756.18 001283294.1_29524001_2 - 0.026 14.1 0.6 0.08 12.4 0.6 1.7 1 1 0 1 1 1 0 Putative esterase Hormone_6 PF00236.16 001267760.1_08021001_1 - 6e-51 170.3 10.5 7e-51 170.1 10.5 1.0 1 0 0 1 1 1 1 Glycoprotein hormone DUF1218 PF06749.10 001267760.1_08021001_1 - 1.1 9.7 4.5 2.6 8.5 3.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1218) Pribosyltran PF00156.25 001283594.1_29523001_1 - 4.6e-22 78.1 0.0 6.3e-22 77.7 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.4 001286141.1_29525001_3 - 1.1e-52 178.3 0.0 1.6e-52 177.9 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.25 001286141.1_29525001_3 - 0.00066 19.1 0.0 0.001 18.5 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Calc_CGRP_IAPP PF00214.17 001285634.1_09022001_1 - 3.2e-46 156.5 0.0 4.2e-46 156.1 0.0 1.1 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family TBD PF12845.5 001286507.1_32924001_1 - 1.1e-16 60.3 0.6 1.1e-16 60.3 0.6 1.8 2 0 0 2 2 2 1 TBD domain Cnn_1N PF07989.9 001286507.1_32924001_2 - 0.08 12.9 2.1 0.13 12.3 2.1 1.3 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 bZIP_2 PF07716.13 001286507.1_32924001_2 - 0.09 12.7 0.6 0.16 12.0 0.6 1.3 1 0 0 1 1 1 0 Basic region leucine zipper DMPK_coil PF08826.8 001286507.1_32924001_2 - 0.12 12.4 0.3 0.19 11.8 0.3 1.3 1 0 0 1 1 1 0 DMPK coiled coil domain like Neurexophilin PF06312.10 001266633.2_29624001_3 - 8e-94 312.9 0.1 1.1e-93 312.5 0.1 1.1 1 0 0 1 1 1 1 Neurexophilin IF4E PF01652.16 001286178.1_32924001_1 - 1.4e-51 174.3 0.9 1.9e-51 173.9 0.9 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Calc_CGRP_IAPP PF00214.17 001285687.1_09022001_2 - 3.9e-42 143.3 0.4 5.4e-42 142.8 0.4 1.2 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family GLYCAM-1 PF05242.9 001285626.1_09022001_2 - 4.9e-59 198.1 4.5 6.7e-59 197.7 4.5 1.2 1 0 0 1 1 1 1 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) TMEM100 PF16311.3 001285626.1_09022001_2 - 0.065 12.7 0.0 7.8 6.0 0.0 2.2 2 0 0 2 2 2 0 Transmembrane protein 100 FA_desaturase PF00487.22 001285619.1_09023001_1 - 1.9e-16 60.5 15.6 3e-16 59.9 15.6 1.3 1 0 0 1 1 1 1 Fatty acid desaturase G-alpha PF00503.18 073434.1_49824120_1 - 1e-99 333.9 0.2 1.3e-99 333.6 0.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 073434.1_49824120_1 - 1e-13 51.0 0.8 3.1e-13 49.4 0.5 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.11 073434.1_49824120_1 - 0.034 14.2 0.9 0.096 12.8 0.2 1.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.18 033292.2_49824120_1 - 1.2e-100 337.0 0.2 1.5e-100 336.7 0.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 033292.2_49824120_1 - 1.6e-13 50.3 1.5 3.1e-13 49.4 0.5 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.11 033292.2_49824120_1 - 0.022 14.8 0.9 0.096 12.8 0.2 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.18 033291.2_49824120_1 - 1.2e-97 327.1 0.0 1.6e-97 326.7 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 033291.2_49824120_1 - 1.3e-13 50.7 1.0 3.3e-13 49.3 0.5 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.11 033291.2_49824120_1 - 0.041 14.0 0.5 0.1 12.7 0.2 1.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Pkinase PF00069.23 001260568.1_29626001_3 - 1.1e-51 175.7 0.0 1.4e-51 175.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001260568.1_29626001_3 - 1.3e-24 86.8 0.0 1.9e-24 86.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DMPK_coil PF08826.8 001260568.1_29626001_3 - 1.9e-21 75.8 15.2 1.9e-21 75.8 15.2 1.8 2 0 0 2 2 2 1 DMPK coiled coil domain like Kinase-like PF14531.4 001260568.1_29626001_3 - 5.9e-08 32.2 0.0 1.1e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.4 001260568.1_29626001_3 - 0.0003 20.4 0.0 0.025 14.1 0.0 2.3 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.12 001260568.1_29626001_3 - 0.0029 16.9 0.0 0.0058 15.9 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family AP_endonuc_2 PF01261.22 001260568.1_29626001_3 - 0.012 15.0 0.4 1.5 8.0 0.2 2.3 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel IncA PF04156.12 001260568.1_29626001_3 - 0.056 13.1 6.6 0.11 12.1 6.6 1.4 1 0 0 1 1 1 0 IncA protein Seadorna_VP7 PF07387.9 001260568.1_29626001_3 - 0.22 10.4 0.0 0.35 9.7 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.21 001260568.1_29626001_3 - 0.7 9.6 0.0 0.7 9.6 0.0 3.0 3 0 0 3 3 3 0 Phosphotransferase enzyme family APG6 PF04111.10 001260568.1_29626001_3 - 3.1 7.0 4.6 4.7 6.4 4.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 ZapB PF06005.10 001260568.1_29626001_3 - 4.6 7.6 10.9 11 6.5 10.9 1.5 1 0 0 1 1 1 0 Cell division protein ZapB CLN6 PF15156.4 001040289.1_39522001_1 - 1.1e-161 536.5 15.3 1.3e-161 536.3 15.3 1.0 1 0 0 1 1 1 1 Ceroid-lipofuscinosis neuronal protein 6 Zn_dep_PLPC PF00882.16 001040289.1_39522001_1 - 0.046 13.6 0.1 0.075 12.9 0.1 1.4 1 0 0 1 1 1 0 Zinc dependent phospholipase C Peptidase_U4 PF03419.11 001040289.1_39522001_1 - 4.8 6.2 12.7 0.23 10.6 5.1 2.0 1 1 1 2 2 2 0 Sporulation factor SpoIIGA CLN6 PF15156.4 001243614.1_49825001_3 - 4.9e-161 534.4 16.9 6.2e-161 534.1 16.9 1.1 1 0 0 1 1 1 1 Ceroid-lipofuscinosis neuronal protein 6 Peptidase_U4 PF03419.11 001243614.1_49825001_3 - 0.021 14.0 0.3 0.021 14.0 0.3 2.0 1 1 1 2 2 2 0 Sporulation factor SpoIIGA CcmD PF04995.12 001243614.1_49825001_3 - 4.9 7.2 8.5 24 5.0 0.1 2.7 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) Ferric_reduct PF01794.17 001171274.1_37923001_1 - 2.9e-14 53.2 2.9 2.9e-14 53.2 2.9 2.5 1 1 1 2 2 2 2 Ferric reductase like transmembrane component EGF PF00008.25 001048187.1_49823001_3 - 1.6e-23 82.5 78.1 6.8e-08 32.5 10.3 6.8 6 1 0 6 6 6 5 EGF-like domain hEGF PF12661.5 001048187.1_49823001_3 - 4.1e-16 58.9 71.4 2.9e-05 24.4 7.2 7.7 7 0 0 7 7 7 6 Human growth factor-like EGF EGF_2 PF07974.11 001048187.1_49823001_3 - 3.4e-15 56.0 85.1 0.00013 22.1 11.8 6.5 6 0 0 6 6 6 5 EGF-like domain EGF_3 PF12947.5 001048187.1_49823001_3 - 0.0022 18.0 6.3 0.0022 18.0 6.3 5.9 3 2 1 4 4 4 3 EGF domain EGF_MSP1_1 PF12946.5 001048187.1_49823001_3 - 0.0033 17.3 8.4 0.0033 17.3 8.4 6.0 6 1 0 6 6 6 1 MSP1 EGF domain 1 EGF_CA PF07645.13 001048187.1_49823001_3 - 0.0069 16.4 10.9 0.0069 16.4 10.9 6.2 1 1 5 6 6 6 2 Calcium-binding EGF domain FA_desaturase PF00487.22 213781.1_49829001_3 - 1.5e-14 54.3 16.3 2.7e-14 53.5 16.3 1.4 1 0 0 1 1 1 1 Fatty acid desaturase CD36 PF01130.19 001285578.1_09025001_3 - 8.3e-148 492.6 0.3 1e-147 492.3 0.3 1.1 1 0 0 1 1 1 1 CD36 family DUF3068 PF11271.6 001285578.1_09025001_3 - 0.075 12.2 0.0 0.2 10.8 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3068) Hormone_1 PF00103.18 001290346.1_08022001_3 - 5.3e-56 189.6 0.1 6.2e-56 189.4 0.1 1.0 1 0 0 1 1 1 1 Somatotropin hormone family HD PF01966.20 001292105.1_49828001_2 - 6.9e-15 55.2 0.0 1.2e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 HD domain SAM_2 PF07647.15 001292105.1_49828001_2 - 8.9e-09 35.2 0.0 2.1e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 001292105.1_49828001_2 - 1.9e-05 24.9 0.1 5.4e-05 23.4 0.0 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PDEase_I PF00233.17 001292105.1_49828001_2 - 0.027 14.1 0.0 0.047 13.3 0.0 1.3 1 0 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase DUF3524 PF12038.6 172662.3_32926001_2 - 1e-70 236.8 0.1 1.4e-70 236.3 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3524) Glycos_transf_1 PF00534.18 172662.3_32926001_2 - 2.2e-08 33.7 0.0 4.6e-08 32.7 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.4 172662.3_32926001_2 - 0.17 12.2 0.0 0.73 10.1 0.0 2.0 2 0 0 2 2 2 0 Glycosyl transferases group 1 Pkinase PF00069.23 146209.1_26229120_1 - 6.3e-06 25.6 0.0 9.8e-06 25.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain MIT PF04212.16 146209.1_26229120_2 - 3.3e-16 59.0 0.9 6e-16 58.1 0.9 1.4 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain PX PF00787.22 146209.1_26229120_2 - 9.9e-13 47.9 0.6 1.9e-12 47.0 0.6 1.4 1 0 0 1 1 1 1 PX domain Pkinase PF00069.23 146209.1_26229120_2 - 1.1e-11 44.5 0.0 1.7e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 146209.1_26229120_2 - 0.002 17.3 0.0 0.0033 16.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Trypsin PF00089.24 001244379.2_49822001_3 - 1.5e-68 230.8 1.5 1.7e-68 230.6 1.5 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001244379.2_49822001_3 - 2.4e-06 28.4 0.1 4.4e-06 27.5 0.1 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF316 PF03761.13 001244379.2_49822001_3 - 0.011 15.1 0.0 0.022 14.2 0.0 1.5 2 0 0 2 2 2 0 Chymotrypsin family Peptidase-S1 DUF1986 PF09342.9 001244379.2_49822001_3 - 0.11 12.7 0.1 0.33 11.2 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF1986) 7tm_2 PF00002.22 001009454.2_39523001_1 - 6.6e-76 254.7 9.5 1.1e-75 254.0 9.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 001009454.2_39523001_1 - 6.9e-19 67.8 1.7 6.9e-19 67.8 1.7 2.7 3 0 0 3 3 3 1 Hormone receptor domain Dicty_CAR PF05462.9 001009454.2_39523001_1 - 0.0084 15.1 8.6 0.014 14.5 8.6 1.3 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor VKOR PF07884.12 001009454.2_39523001_1 - 0.91 9.6 10.5 0.64 10.1 7.9 2.1 1 1 1 2 2 2 0 Vitamin K epoxide reductase family Motilin_ghrelin PF04644.10 001032807.2_29622001_1 - 1e-16 60.3 0.7 1.7e-16 59.6 0.7 1.3 1 0 0 1 1 1 1 Motilin/ghrelin Motilin_assoc PF04643.10 001032807.2_29622001_1 - 5.7e-11 42.0 0.0 9.4e-11 41.3 0.0 1.3 1 0 0 1 1 1 1 Motilin/ghrelin-associated peptide SIR2_2 PF13289.4 029432.2_32929001_1 - 0.15 12.0 0.0 0.45 10.5 0.0 1.8 1 0 0 1 1 1 0 SIR2-like domain CTNNBL PF08216.9 001315760.1_49824001_1 - 1.2e-41 140.9 0.9 3.7e-41 139.4 0.9 1.9 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear Arm PF00514.21 001315760.1_49824001_1 - 0.0004 20.2 4.6 0.61 10.1 0.2 3.6 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.7 001315760.1_49824001_1 - 0.052 13.5 0.1 0.18 11.7 0.1 2.0 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain DASH_Dad4 PF08650.8 001315760.1_49824001_1 - 0.32 10.9 2.6 9.8 6.1 0.1 3.6 4 0 0 4 4 4 0 DASH complex subunit Dad4 Cyto_heme_lyase PF01265.15 001331049.1_32926001_1 - 4.5e-71 239.7 8.1 1.1e-70 238.5 8.1 1.5 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase CDP-OH_P_transf PF01066.19 027652.3_32929001_2 - 4.8e-15 56.0 0.1 4.8e-15 56.0 0.1 2.8 3 0 0 3 3 3 1 CDP-alcohol phosphatidyltransferase TRAPP PF04051.14 001331181.1_32922001_2 - 2.7e-31 108.1 0.0 3.6e-31 107.7 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Hormone_6 PF00236.16 001304918.1_01321001_1 - 1.7e-52 175.2 11.1 2e-52 175.0 11.1 1.1 1 0 0 1 1 1 1 Glycoprotein hormone DUF1218 PF06749.10 001304918.1_01321001_1 - 2.3 8.6 6.1 1.9 9.0 4.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1218) FKBP_C PF00254.26 001315611.1_49829001_3 - 5.6e-46 154.7 0.0 2.3e-29 101.4 0.0 2.3 2 0 0 2 2 2 2 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.26 001315611.1_49829001_3 - 8.8e-17 60.0 3.3 2.5e-07 30.1 0.8 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.15 001315611.1_49829001_3 - 5.1e-11 41.7 2.6 0.00039 20.2 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 001315611.1_49829001_3 - 1.8e-08 33.8 2.9 0.00022 21.1 0.4 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.4 001315611.1_49829001_3 - 1.3e-06 28.6 1.0 0.078 13.4 0.3 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.4 001315611.1_49829001_3 - 2.7e-06 27.5 2.5 0.19 12.3 0.2 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.4 001315611.1_49829001_3 - 2.7e-05 24.2 0.3 0.00083 19.5 0.6 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.4 001315611.1_49829001_3 - 9.1e-05 22.1 0.6 0.00067 19.4 0.2 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 001315611.1_49829001_3 - 0.00021 21.2 1.4 0.053 13.5 0.2 2.4 1 1 1 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.4 001315611.1_49829001_3 - 0.00056 19.9 0.0 0.001 19.0 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.4 001315611.1_49829001_3 - 0.001 18.6 0.8 0.27 10.8 0.0 3.2 2 1 1 3 3 3 1 TPR repeat PknG_TPR PF16918.3 001315611.1_49829001_3 - 0.0075 14.9 0.1 0.011 14.3 0.1 1.1 1 0 0 1 1 1 1 Protein kinase G tetratricopeptide repeat TPR_14 PF13428.4 001315611.1_49829001_3 - 0.011 16.3 0.2 0.86 10.5 0.0 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.5 001315611.1_49829001_3 - 0.018 15.1 4.2 0.092 12.8 1.7 2.7 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.4 001315611.1_49829001_3 - 0.039 14.5 0.5 8.3 7.1 0.0 2.9 4 0 0 4 4 2 0 Tetratricopeptide repeat TPR_10 PF13374.4 001315611.1_49829001_3 - 0.046 13.5 0.5 0.28 11.0 0.2 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Leptin PF02024.13 001193672.1_39722001_1 - 8e-73 242.9 0.3 9e-73 242.7 0.3 1.0 1 0 0 1 1 1 1 Leptin RRM_1 PF00076.20 001315764.1_49824001_1 - 8.6e-11 41.4 0.1 3.2e-10 39.5 0.1 1.9 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP PF00641.16 001315764.1_49824001_1 - 3.4e-07 29.3 6.6 5e-07 28.8 6.6 1.3 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others IL15 PF02372.13 001304915.1_01321001_3 - 8.3e-53 177.9 4.5 8.3e-53 177.9 4.5 1.7 2 0 0 2 2 2 1 Interleukin 15 Glyco_transf_10 PF00852.17 001008985.2_39724001_1 - 1.6e-63 213.5 0.0 2.1e-63 213.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.3 001008985.2_39724001_1 - 2.5e-38 130.8 0.0 4.3e-38 130.0 0.0 1.4 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Ras PF00071.20 001310590.1_32922001_3 - 1.4e-38 131.9 0.1 1.7e-38 131.7 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001310590.1_32922001_3 - 2.8e-26 92.0 0.1 3.9e-26 91.5 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001310590.1_32922001_3 - 4e-12 45.8 0.0 5.3e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001310590.1_32922001_3 - 3.3e-05 23.2 0.0 4.3e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.18 001310590.1_32922001_3 - 0.021 13.8 0.6 0.12 11.3 0.2 2.0 1 1 1 2 2 2 0 G-protein alpha subunit PduV-EutP PF10662.7 001310590.1_32922001_3 - 0.055 13.1 0.1 0.11 12.0 0.1 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation 7tm_1 PF00001.19 001171123.2_37929001_2 - 1.2e-56 191.8 0.0 1.7e-56 191.3 0.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001171123.2_37929001_2 - 5.6e-06 26.2 6.2 5.6e-06 26.2 6.2 1.9 1 1 1 2 2 2 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001171123.2_37929001_2 - 0.001 18.4 13.3 0.0047 16.2 2.8 2.9 3 0 0 3 3 3 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.19 001080788.2_39723001_1 - 6.8e-34 117.2 20.6 1.6e-33 116.0 20.6 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-LITAF-like PF10601.7 001080788.2_39723001_1 - 4.2 7.6 7.9 22 5.3 0.3 3.8 3 1 1 4 4 4 0 LITAF-like zinc ribbon domain p450 PF00067.20 001315734.1_49825001_2 - 6.3e-150 499.8 0.0 7.4e-150 499.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cys_knot PF00007.20 001304859.1_01321001_1 - 4.8e-33 113.5 2.5 5.5e-33 113.3 2.5 1.0 1 0 0 1 1 1 1 Cystine-knot domain IFN-gamma PF00714.15 001193665.1_39722001_1 - 1.7e-66 222.1 3.8 2e-66 221.9 3.8 1.0 1 0 0 1 1 1 1 Interferon gamma API5 PF05918.9 001193665.1_39722001_1 - 0.0032 16.2 2.1 0.0066 15.2 0.7 1.8 1 1 1 2 2 2 1 Apoptosis inhibitory protein 5 (API5) Tup_N PF08581.8 001193665.1_39722001_1 - 0.27 11.4 2.9 0.41 10.8 0.7 2.2 1 1 1 2 2 2 0 Tup N-terminal CTP_transf_like PF01467.24 001347615.1_32924001_1 - 3.5e-46 156.8 0.0 1.9e-30 105.8 0.0 2.2 2 0 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.10 001347615.1_32924001_1 - 0.00026 20.8 0.5 0.079 12.7 0.0 2.9 3 0 0 3 3 3 2 FAD synthetase ScdA_N PF04405.12 001347615.1_32924001_1 - 0.033 13.7 0.3 6.1 6.5 0.0 2.8 3 0 0 3 3 3 0 Domain of Unknown function (DUF542) DUF2968 PF11180.6 147238.1_26226120_2 - 0.063 12.8 7.6 0.13 11.9 7.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Mt_ATP-synt_D PF05873.10 147238.1_26226120_2 - 0.085 12.6 3.8 0.14 11.9 2.7 1.8 1 1 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) Atg14 PF10186.7 147238.1_26226120_2 - 0.13 11.2 15.6 0.26 10.2 15.6 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 UPF0184 PF03670.11 147238.1_26226120_2 - 0.15 12.4 2.1 0.36 11.1 2.1 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) Spc7 PF08317.9 147238.1_26226120_2 - 0.3 9.8 18.9 0.53 9.0 18.9 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein LPP PF04728.11 147238.1_26226120_2 - 1.9 8.8 5.8 0.9 9.8 3.0 1.9 2 0 0 2 2 2 0 Lipoprotein leucine-zipper K_channel_TID PF07941.9 144385.1_26223120_3 - 0.059 13.7 5.7 0.13 12.6 5.7 1.5 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Atg14 PF10186.7 147237.1_26226120_2 - 0.068 12.1 14.7 0.13 11.2 14.7 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2968 PF11180.6 147237.1_26226120_2 - 0.073 12.6 7.9 0.14 11.7 7.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Mt_ATP-synt_D PF05873.10 147237.1_26226120_2 - 0.12 12.1 4.4 0.12 12.0 2.7 1.9 1 1 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) UPF0184 PF03670.11 147237.1_26226120_2 - 0.14 12.5 2.1 0.34 11.2 2.1 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) Spc7 PF08317.9 147237.1_26226120_2 - 0.26 10.0 18.9 0.5 9.1 18.9 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein LPP PF04728.11 147237.1_26226120_2 - 1.8 8.9 5.8 0.86 9.9 3.0 1.9 2 0 0 2 2 2 0 Lipoprotein leucine-zipper EF-hand_1 PF00036.30 025618.3_32925001_1 - 3.8e-13 47.8 0.2 0.0055 16.0 0.0 4.7 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.4 025618.3_32925001_1 - 6.8e-13 48.0 0.0 1.9e-08 33.8 0.1 3.0 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 025618.3_32925001_1 - 1.3e-11 43.3 0.1 0.00019 21.0 0.0 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.4 025618.3_32925001_1 - 6.9e-10 39.1 0.0 0.00027 21.2 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 025618.3_32925001_1 - 7.7e-08 31.4 0.5 0.0064 15.8 0.0 3.7 4 0 0 4 4 4 2 EF hand Atrophin-1 PF03154.13 025618.3_32925001_1 - 0.0032 15.7 12.8 0.0043 15.3 12.8 1.1 1 0 0 1 1 1 1 Atrophin-1 family DUF3915 PF13054.4 025618.3_32925001_2 - 0.032 14.1 7.0 0.053 13.4 7.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 025618.3_32925001_2 - 1.1 7.3 18.7 1.4 6.9 18.7 1.0 1 0 0 1 1 1 0 Atrophin-1 family PAXX PF15384.4 001193927.1_29622001_3 - 8.6e-87 289.7 0.0 1e-86 289.5 0.0 1.1 1 0 0 1 1 1 1 PAXX, PAralog of XRCC4 and XLF, also called C9orf142 ART PF01129.16 001256833.3_37923001_2 - 1.3e-92 309.0 0.0 1.6e-92 308.7 0.0 1.1 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.12 001256833.3_37923001_2 - 0.0014 17.9 0.0 0.0026 17.0 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme SIR2 PF02146.15 001145750.2_49828001_1 - 1.3e-61 207.5 0.0 2e-61 206.9 0.0 1.3 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.11 001145750.2_49828001_1 - 0.016 14.9 0.2 0.025 14.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.20 001145750.2_49828001_1 - 0.028 14.1 0.0 8.1 6.1 0.0 2.2 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain HSP20 PF00011.19 001314333.3_09023001_1 - 2.3e-05 24.4 0.0 3.5e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family SSI PF00720.15 001314333.3_09023001_2 - 0.012 15.5 5.7 0.021 14.6 5.7 1.4 1 0 0 1 1 1 0 Subtilisin inhibitor-like BAR PF03114.16 136714.1_26224120_1 - 2e-17 63.5 0.1 2.4e-17 63.2 0.1 1.1 1 0 0 1 1 1 1 BAR domain BAR PF03114.16 136714.1_26224120_3 - 4.1e-55 186.9 3.0 5.2e-55 186.5 3.0 1.1 1 0 0 1 1 1 1 BAR domain SH3_2 PF07653.15 136714.1_26224120_3 - 1.2e-12 47.1 0.2 3.3e-12 45.8 0.1 1.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 136714.1_26224120_3 - 3.6e-12 45.6 0.2 7.5e-12 44.5 0.2 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 136714.1_26224120_3 - 4.4e-12 45.5 0.1 7.9e-12 44.7 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain BAR_2 PF10455.7 136714.1_26224120_3 - 3.1e-05 23.1 1.8 4.1e-05 22.7 1.8 1.1 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_3 PF16746.3 136714.1_26224120_3 - 7.9e-05 22.3 1.6 0.00094 18.8 1.6 2.0 1 1 0 1 1 1 1 BAR domain of APPL family DUF824 PF05688.9 136714.1_26224120_3 - 0.13 12.0 0.1 0.25 11.1 0.1 1.4 1 0 0 1 1 1 0 Salmonella repeat of unknown function (DUF824) COBRA1 PF06209.11 001310162.1_49825001_1 - 2e-242 805.0 0.3 2.4e-242 804.7 0.3 1.1 1 0 0 1 1 1 1 Cofactor of BRCA1 (COBRA1) DDT PF02791.15 001310162.1_49825001_1 - 7.9 6.7 7.2 26 5.1 3.5 3.0 3 0 0 3 3 3 0 DDT domain MH2 PF03166.12 001244175.1_49826001_1 - 1.9e-48 165.0 0.6 2.6e-48 164.6 0.6 1.2 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.14 001244175.1_49826001_1 - 3.7e-30 104.1 0.5 7.3e-30 103.1 0.5 1.5 1 0 0 1 1 1 1 MH1 domain EF-hand_1 PF00036.30 001194980.2_49823001_2 - 4.8e-33 110.1 10.6 3.2e-06 26.2 0.7 5.5 5 0 0 5 5 5 5 EF hand EF-hand_6 PF13405.4 001194980.2_49823001_2 - 1.6e-30 102.3 9.4 2.3e-06 26.9 0.7 5.5 5 0 0 5 5 5 5 EF-hand domain EF-hand_7 PF13499.4 001194980.2_49823001_2 - 1.3e-26 92.7 5.7 6.1e-10 39.3 0.1 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 001194980.2_49823001_2 - 3.4e-20 70.5 12.7 0.00055 19.2 0.1 5.9 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.4 001194980.2_49823001_2 - 5.3e-12 45.2 10.1 0.00018 21.0 0.4 5.1 4 1 1 5 5 5 4 EF-hand domain pair GPHH PF16905.3 001194980.2_49823001_2 - 2e-06 27.4 0.0 1.1 9.0 0.0 4.1 4 0 0 4 4 4 2 Voltage-dependent L-type calcium channel, IQ-associated Caleosin PF05042.11 001194980.2_49823001_2 - 0.0063 16.3 5.8 4.1 7.2 0.3 3.8 2 2 2 4 4 4 2 Caleosin related protein EF-hand_10 PF14788.4 001194980.2_49823001_2 - 0.016 14.9 6.2 1.1 9.0 0.2 4.4 5 0 0 5 5 5 0 EF hand SPARC_Ca_bdg PF10591.7 001194980.2_49823001_2 - 0.093 12.9 1.5 31 4.8 0.1 3.9 1 1 2 4 4 3 0 Secreted protein acidic and rich in cysteine Ca binding region RecG_N PF17190.2 001194980.2_49823001_2 - 0.22 12.2 5.6 6.6 7.4 0.3 2.9 3 0 0 3 3 3 0 RecG N-terminal helical domain CHCH PF06747.11 001190155.1_49823001_3 - 3.3e-09 36.5 5.9 7e-09 35.5 5.9 1.6 1 0 0 1 1 1 1 CHCH domain MTCP1 PF08991.8 001190155.1_49823001_3 - 0.12 12.5 1.0 0.31 11.2 1.0 1.7 1 0 0 1 1 1 0 Mature-T-Cell Proliferation I type PX PF00787.22 001244589.1_49827001_3 - 7.2e-23 80.6 6.0 2.8e-22 78.7 6.0 2.1 1 0 0 1 1 1 1 PX domain PLDc PF00614.20 001244589.1_49827001_3 - 3.7e-15 55.3 1.1 9.2e-08 31.8 0.1 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.4 001244589.1_49827001_3 - 7.1e-15 54.9 0.3 1.8e-08 34.2 0.2 3.0 2 1 0 2 2 2 2 PLD-like domain PH PF00169.27 001244589.1_49827001_3 - 2.7e-08 34.1 0.1 7.3e-08 32.7 0.1 1.8 1 0 0 1 1 1 1 PH domain zf-HC5HC2H PF13771.4 001244327.1_49824001_3 - 3.3e-19 68.8 10.2 6.5e-19 67.8 8.0 2.2 2 0 0 2 2 2 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.4 001244327.1_49824001_3 - 2.7e-08 33.8 7.1 6.3e-08 32.6 6.9 1.7 1 1 1 2 2 2 1 PHD-zinc-finger like domain DivIC PF04977.13 001244327.1_49824001_3 - 0.66 9.7 2.2 1.2 8.8 2.2 1.3 1 0 0 1 1 1 0 Septum formation initiator RRM_1 PF00076.20 001243447.1_49826001_3 - 3.6e-12 45.8 0.0 5.5e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) eIF-4B PF06273.9 001243447.1_49826001_3 - 1.3 7.8 11.8 0.013 14.4 3.6 1.7 2 0 0 2 2 2 0 Plant specific eukaryotic initiation factor 4B 7tm_1 PF00001.19 001244168.1_49823001_1 - 5.1e-41 140.5 19.3 1e-40 139.6 19.3 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 001244168.1_49823001_1 - 0.0032 16.7 0.8 0.019 14.1 0.8 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw SHIPPO-rpt PF07004.10 001206375.1_49822001_3 - 1.3e-15 57.4 32.0 0.00012 22.7 0.3 6.6 6 0 0 6 6 6 6 Sperm-tail PG-rich repeat SAPS PF04499.13 001206372.1_49828001_3 - 1.3e-107 360.4 0.0 1.6e-64 218.4 0.0 2.7 2 1 1 3 3 3 2 SIT4 phosphatase-associated protein DIE2_ALG10 PF04922.10 001244234.1_49828001_3 - 1.3e-127 426.2 31.1 1.7e-127 425.8 31.1 1.1 1 0 0 1 1 1 1 DIE2/ALG10 family LIM PF00412.20 001258424.2_49823001_1 - 3.8e-33 113.4 26.9 9.5e-17 60.8 8.8 2.3 2 0 0 2 2 2 2 LIM domain Homeobox PF00046.27 001258424.2_49823001_1 - 6.3e-18 64.2 2.3 1.3e-17 63.2 2.3 1.6 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001258424.2_49823001_1 - 0.00011 21.9 0.0 0.00025 20.7 0.0 1.6 1 0 0 1 1 1 1 Homeobox KN domain Dppa2_A PF14049.4 001258424.2_49823001_1 - 0.052 13.6 0.2 0.11 12.7 0.2 1.5 1 0 0 1 1 1 0 Dppa2/4 conserved region in higher vertebrates PNISR PF15996.3 001258424.2_49823001_1 - 0.11 12.6 7.1 0.23 11.5 0.3 2.1 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Keratin_assoc PF09775.7 001190186.1_49822001_1 - 3.5e-55 185.0 6.2 4.3e-55 184.7 6.2 1.0 1 0 0 1 1 1 1 Keratinocyte-associated protein 2 DUF1705 PF08019.10 001190186.1_49822001_1 - 2.4 7.9 7.6 14 5.4 3.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1705) SIR2 PF02146.15 001114270.2_49823001_1 - 9.1e-53 178.7 0.0 1.3e-52 178.2 0.0 1.2 1 0 0 1 1 1 1 Sir2 family Fasciclin PF02469.20 001206351.1_49827001_2 - 1.5e-106 351.6 0.1 1.5e-28 99.4 0.0 4.2 4 0 0 4 4 4 4 Fasciclin domain Prefoldin_2 PF01920.18 001185179.1_49822001_3 - 9.7e-26 89.7 10.9 1.2e-25 89.3 10.9 1.1 1 0 0 1 1 1 1 Prefoldin subunit IncA PF04156.12 001185179.1_49822001_3 - 1.3e-06 28.2 7.7 1.7e-06 27.8 7.7 1.1 1 0 0 1 1 1 1 IncA protein Prefoldin PF02996.15 001185179.1_49822001_3 - 0.00029 20.6 7.6 0.00046 20.0 7.6 1.3 1 0 0 1 1 1 1 Prefoldin subunit ALIX_LYPXL_bnd PF13949.4 001185179.1_49822001_3 - 0.0025 17.0 5.5 0.45 9.6 0.1 2.0 2 0 0 2 2 2 2 ALIX V-shaped domain binding to HIV YgaB PF14182.4 001185179.1_49822001_3 - 0.016 15.6 12.1 0.39 11.1 1.9 2.5 2 1 0 2 2 2 0 YgaB-like protein ADIP PF11559.6 001185179.1_49822001_3 - 0.027 14.4 1.2 0.027 14.4 1.2 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Occludin_ELL PF07303.11 001185179.1_49822001_3 - 0.029 14.9 6.1 0.25 11.9 0.9 2.1 2 0 0 2 2 2 0 Occludin homology domain BRE1 PF08647.9 001185179.1_49822001_3 - 0.047 13.6 10.2 0.17 11.9 2.0 2.2 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase OmpH PF03938.12 001185179.1_49822001_3 - 0.055 13.3 17.5 0.13 12.1 6.0 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) THOC7 PF05615.11 001185179.1_49822001_3 - 0.075 13.2 14.6 0.053 13.7 6.0 2.2 2 0 0 2 2 2 0 Tho complex subunit 7 DUF3450 PF11932.6 001185179.1_49822001_3 - 0.082 12.1 11.6 0.034 13.3 4.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Prefoldin_3 PF13758.4 001185179.1_49822001_3 - 0.14 12.1 4.1 0.21 11.5 2.8 2.0 1 1 0 1 1 1 0 Prefoldin subunit DUF4201 PF13870.4 001185179.1_49822001_3 - 0.19 11.3 9.6 1.4 8.4 1.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) DUF641 PF04859.10 001185179.1_49822001_3 - 0.22 11.7 6.9 0.14 12.4 1.1 2.1 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) GAS PF13851.4 001185179.1_49822001_3 - 0.22 10.7 13.1 0.15 11.3 3.9 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding YscO PF07321.10 001185179.1_49822001_3 - 0.23 11.3 13.8 0.042 13.7 4.6 2.1 2 0 0 2 2 2 0 Type III secretion protein YscO DUF106 PF01956.14 001185179.1_49822001_3 - 0.25 11.0 4.0 2.4 7.7 0.7 2.1 2 0 0 2 2 2 0 Integral membrane protein DUF106 Spc24 PF08286.9 001185179.1_49822001_3 - 0.27 11.4 4.9 0.67 10.1 0.4 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF1664 PF07889.10 001185179.1_49822001_3 - 0.31 10.9 4.7 0.22 11.4 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Seryl_tRNA_N PF02403.20 001185179.1_49822001_3 - 0.32 11.1 6.7 4.3 7.5 0.3 2.3 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain APG6 PF04111.10 001185179.1_49822001_3 - 0.37 10.0 11.8 1.5 8.0 11.8 1.7 1 1 0 1 1 1 0 Autophagy protein Apg6 DUF4407 PF14362.4 001185179.1_49822001_3 - 0.39 9.9 6.9 0.65 9.2 6.9 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) FliJ PF02050.14 001185179.1_49822001_3 - 0.43 10.7 17.1 0.046 13.8 8.0 2.2 2 0 0 2 2 2 0 Flagellar FliJ protein FlaC_arch PF05377.9 001185179.1_49822001_3 - 0.59 10.4 3.8 0.38 11.0 0.3 2.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) TBPIP PF07106.11 001185179.1_49822001_3 - 0.69 9.5 9.1 0.36 10.5 1.1 2.1 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Fib_alpha PF08702.8 001185179.1_49822001_3 - 0.74 9.9 6.8 0.44 10.6 1.4 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family EzrA PF06160.10 001185179.1_49822001_3 - 1.2 7.1 10.6 0.1 10.7 3.2 1.9 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA DUF2089 PF09862.7 001185179.1_49822001_3 - 1.8 8.5 5.1 0.26 11.2 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2089) HIP1_clath_bdg PF16515.3 001185179.1_49822001_3 - 2.9 8.4 14.0 4.5 7.8 2.8 2.2 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DivIVA PF05103.11 001185179.1_49822001_3 - 3.1 7.8 10.4 4.2 7.3 1.6 2.1 2 0 0 2 2 2 0 DivIVA protein DMPK_coil PF08826.8 001185179.1_49822001_3 - 3.4 7.7 17.9 1.3 9.0 5.6 2.2 2 0 0 2 2 2 0 DMPK coiled coil domain like Spc7 PF08317.9 001185179.1_49822001_3 - 3.4 6.3 13.6 5.5 5.6 13.6 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF489 PF04356.10 001185179.1_49822001_3 - 3.9 7.3 8.5 0.74 9.6 1.5 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF489) DUF4404 PF14357.4 001185179.1_49822001_3 - 4.6 7.9 9.3 0.88 10.2 1.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) TMPIT PF07851.11 001185179.1_49822001_3 - 6.1 5.9 6.0 2.4 7.2 1.0 1.9 2 0 0 2 2 2 0 TMPIT-like protein DUF4337 PF14235.4 001185179.1_49822001_3 - 6.7 6.7 10.3 1.5 8.8 3.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) DUF724 PF05266.12 001185179.1_49822001_3 - 7.9 6.1 10.6 40 3.8 10.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Ada3 PF10198.7 001185179.1_49822001_3 - 8.2 6.5 10.7 1.4 9.0 3.4 2.1 1 1 1 2 2 2 0 Histone acetyltransferases subunit 3 Methyltransf_32 PF13679.4 001243324.1_49824001_1 - 4.8e-29 101.3 0.0 6.6e-29 100.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain TRM13 PF05206.12 001243324.1_49824001_1 - 0.061 12.7 0.0 4.3 6.6 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase TRM13 RrnaAD PF00398.18 001243324.1_49824001_1 - 0.11 11.5 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase CHGN PF05679.14 001244442.2_49828001_1 - 1.5e-203 677.2 0.6 1.8e-203 676.9 0.6 1.1 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Fringe PF02434.14 001244442.2_49828001_1 - 7.2e-18 64.8 0.0 1.2e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 Fringe-like Glyco_transf_7C PF02709.12 001244442.2_49828001_1 - 6.2e-10 38.5 0.2 1.5e-09 37.3 0.2 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 001244442.2_49828001_1 - 6.7e-07 28.9 0.1 3.3e-05 23.4 0.1 2.8 2 1 0 2 2 2 1 Glycosyltransferase like family 2 Galactosyl_T PF01762.19 001244442.2_49828001_1 - 0.0014 18.4 0.0 0.014 15.0 0.0 2.6 2 1 0 2 2 2 1 Galactosyltransferase Glyco_transf_21 PF13506.4 001244442.2_49828001_1 - 0.095 12.0 0.0 0.59 9.5 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase family 21 Homeobox PF00046.27 001243352.1_49822001_1 - 8e-25 86.3 2.7 1.5e-24 85.4 2.7 1.5 1 0 0 1 1 1 1 Homeobox domain OAR PF03826.15 001243352.1_49822001_1 - 1.1e-07 31.3 2.9 2.5e-07 30.1 2.9 1.7 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.9 001243352.1_49822001_1 - 0.00038 20.2 0.5 0.0013 18.4 0.0 2.1 2 0 0 2 2 2 1 Homeobox KN domain Sporozoite_P67 PF05642.9 001243352.1_49822001_1 - 0.0043 15.1 2.2 0.0053 14.8 2.2 1.0 1 0 0 1 1 1 1 Sporozoite P67 surface antigen MRP-L20 PF12824.5 001243352.1_49822001_1 - 0.0081 16.2 0.4 0.017 15.1 0.4 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 GRP PF07172.9 001243352.1_49822001_1 - 0.39 11.3 27.0 1.1 9.9 27.0 1.7 1 0 0 1 1 1 0 Glycine rich protein family Ribosomal_60s PF00428.17 001243352.1_49822001_2 - 9.9 6.7 19.8 17 5.9 19.8 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein 7tm_1 PF00001.19 001244296.2_49824001_2 - 6.1e-37 127.2 1.1 1.1e-36 126.3 1.1 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Abhydrolase_9_N PF15420.4 001244296.2_49824001_2 - 0.0076 16.1 0.9 0.013 15.4 0.9 1.3 1 0 0 1 1 1 1 Alpha/beta-hydrolase family N-terminus TGF_beta PF00019.18 001005155.2_49825001_3 - 8.6e-28 97.2 0.2 1.5e-27 96.4 0.2 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.16 001005155.2_49825001_3 - 0.046 13.3 0.2 0.41 10.2 0.0 2.0 2 0 0 2 2 2 0 TGF-beta propeptide HH_signal PF01085.16 001244513.1_49823001_1 - 1.5e-88 294.4 0.0 2e-88 294.0 0.0 1.2 1 0 0 1 1 1 1 Hedgehog amino-terminal signalling domain Hint PF01079.18 001244513.1_49823001_1 - 4.1e-75 251.8 0.0 5.3e-75 251.5 0.0 1.1 1 0 0 1 1 1 1 Hint module Peptidase_M15_3 PF08291.9 001244513.1_49823001_1 - 0.00037 20.4 0.0 0.00059 19.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase M15 Vint PF14623.4 001244513.1_49823001_1 - 0.066 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Hint-domain Ribosomal_S6e PF01092.17 001244513.1_49823001_1 - 0.13 12.1 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S6e Pkinase PF00069.23 001244188.1_49829001_1 - 8.8e-12 44.8 0.0 2e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001244188.1_49829001_1 - 1.1e-05 24.8 0.0 2.7e-05 23.4 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Ribosomal_L2 PF00181.21 001185067.1_49823001_1 - 3.4e-29 100.5 0.1 1.1e-28 98.9 0.1 1.9 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain Ribosomal_L2_C PF03947.16 001185067.1_49823001_1 - 6.7e-29 100.5 0.2 2.1e-28 98.9 0.2 1.8 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain RRM_1 PF00076.20 001243448.1_49826001_3 - 3.5e-12 45.8 0.0 5.3e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) eIF-4B PF06273.9 001243448.1_49826001_3 - 0.0055 15.7 3.1 0.0055 15.7 3.1 1.6 2 0 0 2 2 2 1 Plant specific eukaryotic initiation factor 4B Ank_2 PF12796.5 001205042.1_49826001_1 - 5e-53 177.5 3.1 8.5e-17 61.4 0.1 5.3 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001205042.1_49826001_1 - 3.5e-43 145.3 5.3 2.5e-10 40.5 0.1 7.4 5 2 2 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.28 001205042.1_49826001_1 - 1.1e-35 120.3 9.9 1.3e-07 31.6 0.0 10.3 8 3 1 9 9 9 7 Ankyrin repeat Ank_3 PF13606.4 001205042.1_49826001_1 - 1.4e-31 104.8 6.1 6.3e-05 22.9 0.0 10.6 11 0 0 11 11 11 6 Ankyrin repeat Ank_5 PF13857.4 001205042.1_49826001_1 - 1.6e-25 88.6 7.3 5.7e-06 26.4 0.1 8.4 2 1 6 9 9 9 7 Ankyrin repeats (many copies) SOCS_box PF07525.14 001205042.1_49826001_1 - 1.3e-11 44.5 5.1 3.5e-11 43.1 5.1 1.8 1 0 0 1 1 1 1 SOCS box TAFII28 PF04719.12 001184894.1_49823001_1 - 1.6e-39 133.8 0.1 2.5e-39 133.2 0.1 1.3 1 0 0 1 1 1 1 hTAFII28-like protein conserved region CBFD_NFYB_HMF PF00808.21 001184894.1_49823001_1 - 1.9e-05 24.7 0.0 3.5e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Kelch_1 PF01344.23 001206381.1_49824001_1 - 7.5e-29 98.9 5.8 2.2e-09 36.6 0.1 6.7 6 2 0 6 6 6 4 Kelch motif Kelch_6 PF13964.4 001206381.1_49824001_1 - 2e-22 78.5 3.6 7.3e-05 22.8 0.0 6.1 2 2 4 6 6 6 4 Kelch motif Kelch_4 PF13418.4 001206381.1_49824001_1 - 3e-10 39.7 5.9 0.0026 17.5 0.0 5.7 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_3 PF13415.4 001206381.1_49824001_1 - 6e-10 39.0 3.6 0.0075 16.4 0.0 6.0 5 1 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.13 001206381.1_49824001_1 - 7.2e-09 35.2 0.1 0.031 14.1 0.0 5.3 5 1 0 5 5 5 3 Kelch motif Kelch_5 PF13854.4 001206381.1_49824001_1 - 0.047 13.5 0.7 29 4.6 0.2 3.5 3 0 0 3 3 3 0 Kelch motif Calc_CGRP_IAPP PF00214.17 001206384.1_49821001_1 - 2.7e-06 27.6 0.0 3.1e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family DPM2 PF07297.10 001244059.1_49822001_1 - 7.7e-31 106.1 6.6 1.1e-30 105.6 6.6 1.1 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.10 001244059.1_49822001_1 - 0.062 13.1 2.7 0.084 12.7 2.7 1.2 1 0 0 1 1 1 0 PIG-P hSH3 PF14603.4 104376.1_32927120_2 - 1.8e-14 53.9 0.0 1.5e-13 51.0 0.0 2.3 2 0 0 2 2 2 1 Helically-extended SH3 domain Aldo_ket_red PF00248.19 145511.1_49823120_3 - 2.9e-52 177.5 0.0 3.2e-51 174.1 0.0 1.9 1 1 0 1 1 1 1 Aldo/keto reductase family SBDS_C PF09377.8 024110.1_26224120_2 - 8.9e-33 112.6 2.5 8.9e-33 112.6 2.5 1.5 2 0 0 2 2 2 1 SBDS protein C-terminal domain SBDS PF01172.16 024110.1_26224120_2 - 5.2e-17 61.6 0.1 1.1e-16 60.5 0.1 1.6 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein GidB PF02527.13 024110.1_26224120_2 - 0.34 10.1 4.1 3 7.0 1.1 2.1 1 1 1 2 2 2 0 rRNA small subunit methyltransferase G zf-dskA_traR PF01258.15 038835.1_26222120_2 - 0.072 12.9 0.1 0.19 11.5 0.1 1.8 1 0 0 1 1 1 0 Prokaryotic dksA/traR C4-type zinc finger zf-DHHC PF01529.18 001243057.2_39723001_1 - 1e-31 109.6 11.2 1e-31 109.6 11.2 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF2231 PF09990.7 001243057.2_39723001_1 - 0.12 12.7 4.0 0.06 13.7 1.2 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2231) Fucokinase PF07959.10 001204852.1_49827001_1 - 2.3e-145 484.5 0.0 2.8e-145 484.2 0.0 1.1 1 0 0 1 1 1 1 L-fucokinase Hexapep PF00132.22 001204852.1_49827001_1 - 0.032 13.8 0.7 0.11 12.1 0.1 2.3 2 0 0 2 2 2 0 Bacterial transferase hexapeptide (six repeats) Gal-bind_lectin PF00337.20 001348971.1_49823001_1 - 1.2e-39 134.8 0.5 1.5e-39 134.5 0.5 1.1 1 0 0 1 1 1 1 Galactoside-binding lectin Gal-bind_lectin PF00337.20 001348968.1_49824001_1 - 3.5e-77 256.3 0.4 3.5e-39 133.3 0.5 2.1 2 0 0 2 2 2 2 Galactoside-binding lectin Methyltransf_12 PF08242.10 001206445.1_49825001_1 - 5.2e-18 65.5 0.1 3.5e-17 62.8 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.4 001206445.1_49825001_1 - 6.8e-13 49.0 0.0 1.2e-12 48.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 001206445.1_49825001_1 - 1.1e-12 48.1 0.0 1.9e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001206445.1_49825001_1 - 1.1e-09 38.7 0.0 2.2e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 001206445.1_49825001_1 - 1.4e-09 37.8 0.0 2.2e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.12 001206445.1_49825001_1 - 0.0023 17.4 0.0 0.0037 16.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.16 001206445.1_49825001_1 - 0.035 13.3 0.0 0.053 12.7 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.16 001206445.1_49825001_1 - 0.18 10.8 0.4 1 8.4 0.0 1.9 1 1 1 2 2 2 0 O-methyltransferase Bcl-2 PF00452.17 001348806.1_49828001_2 - 4.5e-25 88.0 0.1 7.6e-25 87.3 0.1 1.4 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family ODC_AZ PF02100.15 001291863.1_24223001_3 - 8.5e-20 70.7 0.0 1.4e-19 70.0 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme RBB1NT PF08169.9 001244179.1_49829001_2 - 1.5e-37 127.6 0.0 7.5e-37 125.4 0.0 2.3 1 0 0 1 1 1 1 RBB1NT (NUC162) domain ARID PF01388.19 001244179.1_49829001_2 - 4.5e-20 72.0 0.0 9e-20 71.0 0.0 1.5 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Tudor-knot PF11717.6 001244179.1_49829001_2 - 3.3e-13 49.2 2.0 1.2e-12 47.4 2.0 2.1 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain PWWP PF00855.15 001244179.1_49829001_2 - 0.2 12.0 12.4 0.74 10.2 0.0 4.2 4 1 0 4 4 4 0 PWWP domain S_100 PF01023.17 001190207.1_49825001_3 - 1.7e-09 37.1 0.6 2.5e-09 36.5 0.6 1.3 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 001190207.1_49825001_3 - 4.6e-05 23.7 0.0 8.2e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.4 001190207.1_49825001_3 - 0.00011 21.5 0.0 0.00019 20.6 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.4 001190207.1_49825001_3 - 0.00017 21.2 0.0 0.00027 20.5 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 001190207.1_49825001_3 - 0.0023 17.2 0.1 0.0078 15.6 0.1 1.9 2 0 0 2 2 2 1 EF hand LRR_9 PF14580.4 001282115.1_49822001_2 - 7.3e-13 48.2 0.0 3.3e-12 46.1 0.0 1.8 1 1 1 2 2 2 1 Leucine-rich repeat LRR_8 PF13855.4 001282115.1_49822001_2 - 2.7e-07 30.1 1.6 2.7e-07 30.1 1.6 2.3 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.5 001282115.1_49822001_2 - 2.9e-07 30.5 7.5 0.00034 20.8 0.2 3.1 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001282115.1_49822001_2 - 0.41 11.2 4.6 1.3e+02 3.6 0.0 4.1 4 0 0 4 4 4 0 Leucine Rich Repeat Methyltransf_12 PF08242.10 001206443.1_49825001_1 - 6.3e-18 65.2 0.1 3.8e-17 62.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.4 001206443.1_49825001_1 - 7.8e-13 48.8 0.0 1.3e-12 48.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 001206443.1_49825001_1 - 9.4e-10 38.5 0.0 1.5e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001206443.1_49825001_1 - 1.3e-09 38.5 0.0 2.4e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 001206443.1_49825001_1 - 1.6e-09 37.6 0.0 2.3e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.12 001206443.1_49825001_1 - 0.0025 17.2 0.0 0.004 16.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.16 001206443.1_49825001_1 - 0.041 13.1 0.0 0.059 12.6 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family DUF4723 PF15851.3 001286976.1_09023001_2 - 0.22 11.5 7.1 0.5 10.4 7.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4723) Brix PF04427.16 001204435.1_49824001_2 - 1.6e-44 152.2 0.2 2.2e-44 151.7 0.2 1.2 1 0 0 1 1 1 1 Brix domain SHIPPO-rpt PF07004.10 001348539.1_49823001_2 - 7.1e-13 48.7 21.8 0.0035 18.1 0.1 6.5 6 0 0 6 6 6 5 Sperm-tail PG-rich repeat EF-hand_1 PF00036.30 001244251.2_49823001_1 - 3.2e-13 48.1 7.6 4.3e-07 28.9 1.6 4.6 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.4 001244251.2_49823001_1 - 1.3e-12 47.9 4.5 3e-07 30.7 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 001244251.2_49823001_1 - 1.4e-10 40.1 7.3 2.7e-07 29.9 0.9 3.3 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.4 001244251.2_49823001_1 - 7.3e-08 31.9 4.3 0.0057 16.3 0.2 3.2 1 1 3 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.4 001244251.2_49823001_1 - 2.7e-05 23.4 2.6 5.6e-05 22.4 1.5 2.1 2 0 0 2 2 2 1 EF hand EF-hand_11 PF08976.9 001244251.2_49823001_1 - 3.1e-05 24.7 0.2 0.00029 21.5 0.1 2.1 1 1 1 2 2 2 1 EF-hand domain EF-hand_9 PF14658.4 001244251.2_49823001_1 - 0.01 16.0 0.0 1.6 9.0 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain GPHH PF16905.3 001244251.2_49823001_1 - 0.018 14.7 0.0 3.3 7.5 0.0 2.3 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated UPF0154 PF03672.11 001244251.2_49823001_1 - 0.026 14.4 0.0 5 7.1 0.0 2.7 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0154) SPARC_Ca_bdg PF10591.7 001244251.2_49823001_1 - 0.064 13.4 0.3 0.12 12.6 0.3 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Seipin PF06775.12 001348785.1_49824001_3 - 5.6e-58 196.2 1.0 7.9e-58 195.7 1.0 1.2 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) UCH PF00443.27 001243188.1_49828001_3 - 5.7e-83 278.2 0.0 7.7e-83 277.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_3 PF14836.4 001243188.1_49828001_3 - 2.9e-31 107.0 0.1 6.7e-31 105.9 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-like domain DUSP PF06337.10 001243188.1_49828001_3 - 4.5e-23 81.5 1.0 1e-22 80.4 1.0 1.7 1 0 0 1 1 1 1 DUSP domain UCH_1 PF13423.4 001243188.1_49828001_3 - 2.2e-20 73.4 0.0 6.5e-13 48.8 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.4 001243188.1_49828001_3 - 9.3e-06 25.4 0.0 0.00021 21.0 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin-specific protease C-terminal USP7_ICP0_bdg PF12436.6 001243188.1_49828001_3 - 0.00036 19.9 0.0 0.00086 18.7 0.0 1.5 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 CW_binding_1 PF01473.18 001243188.1_49828001_3 - 0.23 11.7 4.3 1.1 9.6 4.3 2.2 1 0 0 1 1 1 0 Putative cell wall binding repeat S_100 PF01023.17 001190168.1_49823001_3 - 2.1e-13 49.6 0.0 3.4e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain Ig_2 PF13895.4 001123112.2_49823001_3 - 6.4e-10 39.1 0.0 0.00039 20.6 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001123112.2_49823001_3 - 4.6e-09 36.2 0.0 1.7e-06 27.9 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001123112.2_49823001_3 - 5.4e-06 26.8 0.0 0.012 16.0 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain zf-U11-48K PF05253.10 001258404.2_49822001_2 - 1.2e-17 63.3 9.7 1.2e-10 40.9 3.2 2.6 2 0 0 2 2 2 2 U11-48K-like CHHC zinc finger Gal-bind_lectin PF00337.20 213932.2_49824001_1 - 3.8e-77 256.1 0.4 3.6e-39 133.2 0.5 2.1 2 0 0 2 2 2 2 Galactoside-binding lectin Serpin PF00079.18 001244161.1_49824001_3 - 1.1e-126 422.9 6.5 1.4e-126 422.7 6.5 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Auxin_canalis PF05703.9 001244161.1_49824001_3 - 0.12 12.2 0.2 0.23 11.3 0.2 1.4 1 0 0 1 1 1 0 Auxin canalisation Methyltransf_12 PF08242.10 001206446.1_49825001_1 - 5e-18 65.5 0.1 3.4e-17 62.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.4 001206446.1_49825001_1 - 6.4e-13 49.1 0.0 1.2e-12 48.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 001206446.1_49825001_1 - 2.2e-10 40.6 0.0 3.5e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001206446.1_49825001_1 - 1.1e-09 38.7 0.0 2.1e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 001206446.1_49825001_1 - 1.3e-09 37.9 0.0 2e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.12 001206446.1_49825001_1 - 0.0022 17.4 0.0 0.0036 16.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.16 001206446.1_49825001_1 - 0.035 13.3 0.0 0.052 12.7 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.16 001206446.1_49825001_1 - 0.15 11.1 0.4 1 8.4 0.0 1.9 1 1 1 2 2 2 0 O-methyltransferase PRKCSH-like PF12999.5 001244598.1_49826001_2 - 3.8e-42 143.9 6.9 3.8e-42 143.9 6.9 2.1 1 1 1 2 2 2 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.4 001244598.1_49826001_2 - 2.2e-20 72.8 0.0 5e-20 71.6 0.0 1.5 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.11 001244598.1_49826001_2 - 2.7e-10 41.0 0.5 2.7e-10 41.0 0.5 2.4 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein EF-hand_5 PF13202.4 001244598.1_49826001_2 - 1.8e-07 30.3 0.3 0.00055 19.2 0.0 2.4 2 0 0 2 2 2 2 EF hand Ldl_recept_a PF00057.16 001244598.1_49826001_2 - 1.8e-05 24.7 12.4 0.018 15.1 2.5 2.7 1 1 1 2 2 2 2 Low-density lipoprotein receptor domain class A EF-hand_1 PF00036.30 001244598.1_49826001_2 - 7.2e-05 21.9 0.1 0.079 12.4 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 001244598.1_49826001_2 - 0.00084 19.0 0.4 0.27 11.2 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.4 001244598.1_49826001_2 - 0.0045 17.3 0.4 1.1 9.6 0.1 2.7 2 0 0 2 2 2 1 EF-hand domain pair YjhX_toxin PF09857.7 001244598.1_49826001_2 - 0.11 12.3 0.4 0.21 11.5 0.4 1.3 1 0 0 1 1 1 0 Putative toxin of bacterial toxin-antitoxin pair DUF3391 PF11871.6 001244598.1_49826001_2 - 2.9 8.3 23.8 0.65 10.4 9.9 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) EF-hand_1 PF00036.30 001044572.3_49823001_3 - 2.3e-13 48.5 7.6 4e-07 29.0 1.6 4.6 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.4 001044572.3_49823001_3 - 1.1e-12 48.1 4.5 2.7e-07 30.8 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 001044572.3_49823001_3 - 1.1e-10 40.4 7.3 2.5e-07 30.0 0.9 3.3 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.4 001044572.3_49823001_3 - 6.1e-08 32.2 4.4 0.0054 16.3 0.2 3.3 1 1 3 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.4 001044572.3_49823001_3 - 1.9e-05 23.9 2.3 5.2e-05 22.5 1.5 2.1 2 0 0 2 2 2 1 EF hand EF-hand_11 PF08976.9 001044572.3_49823001_3 - 2.7e-05 24.8 0.2 0.00028 21.6 0.1 2.0 1 1 1 2 2 2 1 EF-hand domain EF-hand_9 PF14658.4 001044572.3_49823001_3 - 0.0089 16.2 0.0 1.5 9.1 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain GPHH PF16905.3 001044572.3_49823001_3 - 0.015 14.9 0.0 3 7.6 0.0 2.3 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated UPF0154 PF03672.11 001044572.3_49823001_3 - 0.022 14.6 0.0 4.7 7.2 0.0 2.7 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0154) SPARC_Ca_bdg PF10591.7 001044572.3_49823001_3 - 0.088 13.0 0.3 0.16 12.2 0.3 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region DUF2666 PF10869.6 001044572.3_49823001_3 - 0.14 12.3 0.0 0.62 10.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2666) zf-CCHC PF00098.21 001244220.1_49823001_3 - 5.5e-14 51.4 28.8 1.3e-05 24.9 0.5 4.3 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_2 PF13696.4 001244220.1_49823001_3 - 0.0003 20.4 23.9 0.28 10.9 2.7 4.3 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_4 PF14392.4 001244220.1_49823001_3 - 0.052 13.1 0.8 0.052 13.1 0.8 4.5 4 0 0 4 4 4 0 Zinc knuckle RIIa PF02197.15 001348766.1_49823001_3 - 4.7e-12 45.2 0.4 1.1e-09 37.7 0.0 2.6 2 0 0 2 2 2 2 Regulatory subunit of type II PKA R-subunit p450 PF00067.20 132429.1_49823120_1 - 0.034 12.8 0.0 0.046 12.3 0.0 1.1 1 0 0 1 1 1 0 Cytochrome P450 p450 PF00067.20 132429.1_49823120_2 - 2.4e-15 56.1 0.1 2.8e-07 29.5 0.1 2.1 2 0 0 2 2 2 2 Cytochrome P450 DUF3915 PF13054.4 131057.1_32928120_1 - 0.42 10.5 5.2 0.87 9.5 5.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) FAM27 PF15832.3 131057.1_32928120_1 - 1.2 9.6 7.5 2.5 8.5 7.5 1.5 1 0 0 1 1 1 0 FAM27 D and E protein family Atrophin-1 PF03154.13 131057.1_32928120_1 - 4 5.5 10.7 5.9 4.9 10.7 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.4 131057.1_32928120_2 - 1.4 8.7 8.9 2.2 8.1 8.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) FAM27 PF15832.3 131057.1_32928120_2 - 1.7 9.1 5.8 3.2 8.2 5.8 1.3 1 0 0 1 1 1 0 FAM27 D and E protein family Atrophin-1 PF03154.13 131057.1_32928120_3 - 0.081 11.1 10.1 0.12 10.6 10.1 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.4 131057.1_32928120_3 - 0.12 12.2 6.0 0.23 11.3 6.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) AMP-binding PF00501.26 001280466.1_39725001_1 - 1.5e-109 366.3 0.0 2.3e-109 365.7 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 001280466.1_39725001_1 - 5.4e-05 24.0 0.0 0.00014 22.6 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.26 001280132.1_39725001_1 - 7.1e-111 370.6 0.0 8.6e-111 370.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 001280132.1_39725001_1 - 2e-05 25.4 0.1 4.3e-05 24.3 0.1 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Ras PF00071.20 147956.1_26226120_1 - 1.5e-08 34.3 0.0 2.1e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 147956.1_26226120_1 - 0.00026 21.1 0.0 0.00045 20.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 147956.1_26226120_1 - 0.06 12.6 0.0 0.081 12.2 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 147956.1_26226120_1 - 0.069 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase Arf PF00025.19 147956.1_26226120_1 - 0.088 12.1 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family EF_assoc_2 PF08356.10 147956.1_26226120_3 - 1.9e-32 111.0 0.0 2.8e-32 110.4 0.0 1.3 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.10 147956.1_26226120_3 - 8.5e-23 79.7 0.0 5.9e-22 77.0 0.0 2.2 2 0 0 2 2 2 1 EF hand associated EF-hand_6 PF13405.4 147956.1_26226120_3 - 0.0015 18.2 0.0 0.0031 17.2 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain Ras PF00071.20 147956.1_26226120_3 - 0.0076 15.7 0.0 0.022 14.2 0.0 1.6 1 1 0 1 1 1 1 Ras family EF-hand_1 PF00036.30 147956.1_26226120_3 - 0.0099 15.2 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.4 147956.1_26226120_3 - 0.04 14.3 0.0 0.071 13.5 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain pair Integrin_alpha2 PF08441.10 001244272.2_49829001_2 - 8e-47 160.0 8.2 1.2e-46 159.4 8.2 1.3 1 0 0 1 1 1 1 Integrin alpha VWA PF00092.26 001244272.2_49829001_2 - 1.5e-40 139.2 0.2 2.8e-40 138.3 0.2 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain FG-GAP PF01839.21 001244272.2_49829001_2 - 7.7e-21 73.8 4.5 1.2e-08 34.8 0.4 3.7 3 0 0 3 3 3 3 FG-GAP repeat VWA_2 PF13519.4 001244272.2_49829001_2 - 2e-14 54.0 0.0 4.8e-14 52.8 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VCBS PF13517.4 001244272.2_49829001_2 - 1.6e-06 28.5 9.1 0.00082 19.8 1.8 4.0 3 0 0 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.4 001244272.2_49829001_2 - 2.1e-06 27.8 5.1 0.095 12.8 0.1 5.1 5 0 0 5 5 5 2 FG-GAP repeat Integrin_alpha PF00357.18 001244272.2_49829001_2 - 0.0018 18.0 2.2 0.0039 16.9 2.2 1.6 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region Arch_flagellin PF01917.14 001244272.2_49829001_2 - 0.0044 17.1 1.0 0.91 9.6 0.1 2.6 2 0 0 2 2 2 2 Archaebacterial flagellin AMP-binding PF00501.26 001195321.1_49826001_1 - 6.4e-108 360.9 0.0 8.5e-108 360.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 001195321.1_49826001_1 - 0.00082 20.2 0.0 0.0017 19.1 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.26 001261550.1_29626001_1 - 2.2e-104 349.3 0.0 2.6e-104 349.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 001261550.1_29626001_1 - 2.7e-05 24.9 0.0 0.00027 21.7 0.0 2.3 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.26 001169032.1_40424001_1 - 3.9e-106 355.0 0.0 5.6e-62 209.6 0.0 2.2 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.4 001169032.1_40424001_1 - 4.3e-05 24.3 0.0 0.00012 22.9 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Vps55 PF04133.12 001266983.1_29625001_2 - 4.4e-38 129.7 7.6 8.4e-38 128.8 7.6 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting 55 AMP-binding PF00501.26 001143698.1_49826001_1 - 3.5e-104 348.6 0.0 4.6e-104 348.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 001143698.1_49826001_1 - 0.0015 19.3 0.0 0.0033 18.2 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain OAD_gamma PF04277.11 001143698.1_49826001_2 - 0.5 10.9 1.7 0.78 10.2 1.7 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain THF_DHG_CYH_C PF02882.17 001193907.1_29623001_1 - 6.5e-62 207.4 2.6 9.8e-62 206.9 2.6 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.21 001193907.1_29623001_1 - 1.1e-37 128.7 0.0 1.6e-37 128.2 0.0 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Sacchrp_dh_NADP PF03435.16 001193907.1_29623001_1 - 0.13 12.4 0.0 0.52 10.4 0.0 2.0 1 1 1 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Toxin_18 PF08087.9 001193907.1_29623001_2 - 3.3 7.7 14.5 1.2 9.0 7.5 2.2 2 0 0 2 2 2 0 Conotoxin O-superfamily AMP-binding PF00501.26 001171343.1_37925001_1 - 6.4e-108 360.9 0.0 1.1e-107 360.2 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 001171343.1_37925001_1 - 4.5e-05 24.2 0.0 0.00011 23.0 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.26 001173103.1_09926001_3 - 6.4e-105 351.0 0.0 7.9e-105 350.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 001173103.1_09926001_3 - 0.0038 18.0 0.0 0.0097 16.7 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.26 001265800.1_29626001_3 - 1.9e-98 329.7 0.0 2.2e-98 329.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 001265800.1_29626001_3 - 8.2e-25 87.5 0.1 1.5e-24 86.7 0.1 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.3 001265800.1_29626001_3 - 4.7e-19 67.9 0.2 1.3e-18 66.5 0.2 1.8 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Vps55 PF04133.12 001131607.1_43526001_3 - 4.5e-38 129.7 7.6 1e-37 128.5 7.6 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting 55 ubiquitin PF00240.21 001171469.1_37924001_1 - 1.1e-15 57.0 0.3 1.1e-15 57.0 0.3 2.0 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.6 001171469.1_37924001_1 - 4.6e-06 26.2 0.1 8.9e-06 25.3 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.29 001171469.1_37924001_1 - 0.0015 18.2 0.0 0.0015 18.2 0.0 2.0 2 0 0 2 2 2 1 UBA/TS-N domain YukD PF08817.8 001171469.1_37924001_1 - 0.0028 18.2 0.0 0.013 16.0 0.0 2.2 1 1 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD HOIP-UBA PF16678.3 001171469.1_37924001_1 - 0.013 15.4 0.1 0.028 14.3 0.1 1.6 1 0 0 1 1 1 0 UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase Rad60-SLD_2 PF13881.4 001171469.1_37924001_1 - 0.066 13.2 0.1 0.17 11.8 0.1 1.7 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF2859 PF11072.6 001171469.1_37924001_1 - 0.11 12.1 2.8 1.4 8.6 0.5 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2859) ubiquitin PF00240.21 001168860.1_40423001_1 - 5.2e-11 42.0 0.2 9.3e-11 41.2 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 001168860.1_40423001_1 - 0.00089 18.9 0.5 0.0015 18.2 0.5 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.8 001168860.1_40423001_1 - 0.0053 17.3 0.1 0.027 15.0 0.0 2.3 2 1 0 2 2 2 1 WXG100 protein secretion system (Wss), protein YukD AMP-binding PF00501.26 001131300.1_43526001_1 - 4.4e-78 262.6 0.0 5.9e-78 262.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 001131300.1_43526001_1 - 1.7e-24 86.4 0.6 3.7e-24 85.4 0.6 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.26 001257202.1_08025001_1 - 1.6e-110 369.5 0.0 2e-110 369.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 001257202.1_08025001_1 - 2.4e-05 25.1 0.0 5.2e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Mst1_SARAH PF11629.6 001257202.1_08025001_3 - 0.24 11.4 0.1 0.41 10.7 0.1 1.2 1 0 0 1 1 1 0 C terminal SARAH domain of Mst1 AMP-binding PF00501.26 001132153.1_43528001_3 - 3.9e-111 371.5 0.0 4.8e-111 371.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 001132153.1_43528001_3 - 1.2e-05 26.0 0.1 2.4e-05 25.1 0.1 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Pterin_4a PF01329.17 001190219.1_49822001_2 - 9.6e-30 102.5 0.1 1.6e-29 101.8 0.1 1.4 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase ARL17 PF15840.3 001190219.1_49822001_2 - 0.1 12.8 0.2 0.24 11.6 0.2 1.6 1 0 0 1 1 1 0 ADP-ribosylation factor-like protein 17 Semenogelin PF05474.9 038076.2_29624120_1 - 5e-124 414.9 25.7 6.3e-124 414.5 25.7 1.0 1 0 0 1 1 1 1 Semenogelin Destabilase PF05497.10 038076.2_29624120_1 - 0.1 12.8 1.4 0.19 11.9 1.4 1.3 1 0 0 1 1 1 0 Destabilase Semenogelin PF05474.9 038076.2_29624120_2 - 2.2e-99 333.5 46.8 3.1e-99 333.0 46.8 1.1 1 0 0 1 1 1 1 Semenogelin FlgH PF02107.14 038076.2_29624120_3 - 0.037 13.5 0.0 4.5 6.7 0.0 2.9 3 0 0 3 3 3 0 Flagellar L-ring protein zf-HC5HC2H PF13771.4 001185103.1_49826001_3 - 5.2e-34 116.2 30.2 2.3e-17 62.9 10.5 3.5 3 0 0 3 3 3 2 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.4 001185103.1_49826001_3 - 4.6e-13 49.2 28.0 2.2e-06 27.7 13.6 2.8 2 1 0 2 2 2 2 PHD-zinc-finger like domain zf-ANAPC11 PF12861.5 001185103.1_49826001_3 - 1.5 8.8 14.1 4.4 7.3 3.8 3.2 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger SCAMP PF04144.11 001185169.1_49824001_2 - 1.9e-68 230.0 18.3 2.4e-68 229.7 18.3 1.1 1 0 0 1 1 1 1 SCAMP family HemY_N PF07219.11 001185169.1_49824001_2 - 3.8 7.6 6.4 3.4 7.8 2.7 2.5 2 0 0 2 2 2 0 HemY protein N-terminus Phage_holin_3_6 PF07332.9 001185169.1_49824001_2 - 5.7 6.9 10.0 0.79 9.6 4.6 2.2 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III 7tm_4 PF13853.4 001000045.1_45722001_1 - 5.5e-52 177.1 20.6 7.2e-52 176.7 20.6 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001000045.1_45722001_1 - 6.3e-18 64.8 19.2 1.2e-17 63.9 19.2 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001000045.1_45722001_1 - 4.6e-06 26.1 22.0 1.7e-05 24.2 22.0 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx GKAP PF03359.11 001244586.1_49826001_1 - 3e-156 520.1 1.0 3e-156 520.1 1.0 2.6 2 1 0 2 2 2 1 Guanylate-kinase-associated protein (GKAP) protein 7tm_3 PF00003.20 001099657.1_45725001_1 - 7.4e-57 192.7 20.3 7.4e-57 192.7 20.3 2.9 2 1 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099657.1_45725001_1 - 1.4e-40 139.3 0.0 2.2e-40 138.7 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region zf-RING_9 PF13901.4 001244715.1_49827001_1 - 9.8e-70 234.6 14.9 9.8e-70 234.6 14.9 1.7 2 0 0 2 2 2 1 Putative zinc-RING and/or ribbon RUN PF02759.17 001244715.1_49827001_1 - 2.7e-09 37.0 0.9 5.9e-09 35.9 0.9 1.6 1 0 0 1 1 1 1 RUN domain 7tm_4 PF13853.4 001193818.1_29622001_2 - 1.2e-38 133.3 19.4 1.4e-38 133.1 19.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001193818.1_29622001_2 - 1.6e-21 76.6 21.8 1.1e-20 73.9 21.8 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001193818.1_29622001_2 - 7.2e-09 35.3 20.2 1.1e-08 34.7 20.2 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Apolipoprotein PF01442.16 001243219.1_49829001_3 - 0.087 12.6 1.0 0.36 10.6 0.8 2.1 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain 7tm_4 PF13853.4 001000363.1_45722001_1 - 1.8e-42 145.9 19.1 2.4e-42 145.5 19.1 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001000363.1_45722001_1 - 7.2e-17 61.4 19.8 7.2e-17 61.4 19.8 1.9 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001000363.1_45722001_1 - 4.5e-05 22.8 18.0 0.00027 20.3 18.0 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Ets PF00178.20 001190254.1_49823001_1 - 9.1e-34 115.7 0.7 1.5e-33 115.0 0.7 1.3 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.14 001190254.1_49823001_1 - 3.4e-24 84.5 0.1 6e-24 83.7 0.1 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain 7tm_1 PF00001.19 001278560.1_39525001_3 - 1.2e-25 90.1 5.5 1.7e-25 89.7 5.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Glyco_transf_6 PF03414.11 132143.2_24228120_1 - 5.7e-39 133.6 0.2 7.7e-39 133.2 0.2 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 6 Glyco_transf_6 PF03414.11 132143.2_24228120_2 - 6.3e-53 179.5 1.3 6.3e-53 179.5 1.3 1.9 1 1 1 2 2 2 2 Glycosyltransferase family 6 Glyco_transf_6 PF03414.11 132147.2_29625120_2 - 1.4e-99 332.8 1.5 1.8e-99 332.4 1.5 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 6 Asp PF00026.21 001289854.2_49829001_3 - 4.7e-44 151.0 0.0 6.3e-44 150.5 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.4 001289854.2_49829001_3 - 2e-10 40.5 0.0 3.2e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal TAXi_N PF14543.4 001289854.2_49829001_3 - 1.4e-05 25.3 0.0 0.011 15.9 0.0 2.4 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Hormone_1 PF00103.18 001042742.1_29622001_1 - 5.3e-55 186.4 0.7 6.3e-55 186.1 0.7 1.0 1 0 0 1 1 1 1 Somatotropin hormone family 7tm_1 PF00001.19 001032866.1_29623001_1 - 6.2e-57 192.7 22.3 7.9e-57 192.4 22.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001032866.1_29623001_1 - 5.1e-10 39.0 20.7 1.3e-09 37.7 20.7 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Git3 PF11710.6 001032866.1_29623001_1 - 0.26 10.9 18.0 0.013 15.1 12.3 1.7 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 DUF4079 PF13301.4 001032866.1_29623001_1 - 3 7.9 6.6 1e+02 2.9 0.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) TRP PF06011.10 001032866.1_29623001_1 - 3.7 6.0 19.2 0.047 12.3 2.9 2.6 3 0 0 3 3 3 0 Transient receptor potential (TRP) ion channel EF-hand_7 PF13499.4 001031777.2_49822001_1 - 1.5e-22 79.7 2.3 1.5e-17 63.7 0.6 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 001031777.2_49822001_1 - 1.2e-18 65.1 5.1 2.7e-07 29.5 0.2 4.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 001031777.2_49822001_1 - 4.9e-15 54.0 6.2 0.00034 20.2 0.1 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 001031777.2_49822001_1 - 2.5e-13 49.4 4.5 1.3e-06 27.9 0.2 3.8 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 001031777.2_49822001_1 - 8.1e-13 47.1 2.4 4.4e-05 22.7 0.2 3.7 4 0 0 4 4 4 2 EF hand SPARC_Ca_bdg PF10591.7 001031777.2_49822001_1 - 1.3e-05 25.4 1.3 0.00097 19.3 1.3 2.8 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.4 001031777.2_49822001_1 - 0.00027 21.1 0.4 0.43 10.8 0.0 3.6 3 1 0 3 3 3 1 EF-hand domain EF-hand_4 PF12763.5 001031777.2_49822001_1 - 0.0051 16.6 0.7 0.069 13.0 0.1 2.6 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand GATA PF00320.25 001044567.1_49824001_2 - 6.6e-29 99.1 19.6 2.1e-14 52.7 5.3 2.5 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.10 001044567.1_49824001_2 - 3.1e-05 23.2 8.3 0.027 13.8 0.7 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.8 001044567.1_49824001_2 - 0.018 15.0 2.1 3.3 7.8 0.1 3.0 2 0 0 2 2 2 0 Zinc ribbon domain DUF2387 PF09526.8 001044567.1_49824001_2 - 0.03 14.3 5.2 3.5 7.7 0.5 3.3 1 1 2 3 3 3 0 Probable metal-binding protein (DUF2387) Auto_anti-p27 PF06677.10 001044567.1_49824001_2 - 0.13 12.3 5.2 1.6 8.8 0.4 2.6 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Prim_Zn_Ribbon PF08273.10 001044567.1_49824001_2 - 0.91 9.8 11.3 0.3 11.4 2.6 2.9 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase DZR PF12773.5 001044567.1_49824001_2 - 1 9.3 11.2 5.1 7.1 1.7 3.1 1 1 2 3 3 3 0 Double zinc ribbon eIF-5_eIF-2B PF01873.15 001044567.1_49824001_2 - 2.7 7.7 5.9 20 5.0 1.2 2.3 2 0 0 2 2 2 0 Domain found in IF2B/IF5 OrfB_Zn_ribbon PF07282.9 001044567.1_49824001_2 - 4 7.3 11.3 3.4 7.5 1.2 3.0 3 0 0 3 3 3 0 Putative transposase DNA-binding domain Vps36-NZF-N PF16988.3 001044567.1_49824001_2 - 4.9 6.5 6.7 1.8 7.9 0.3 2.8 3 0 0 3 3 3 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Lep_receptor_Ig PF06328.9 001009763.1_39526001_1 - 4.1e-24 84.3 0.6 2.3e-23 81.9 0.6 2.4 1 0 0 1 1 1 1 Ig-like C2-type domain fn3 PF00041.19 001009763.1_39526001_1 - 6.8e-10 39.0 5.6 7.7e-05 22.8 0.0 5.0 5 1 0 5 5 5 2 Fibronectin type III domain Interfer-bind PF09294.8 001009763.1_39526001_1 - 0.025 14.7 0.1 0.11 12.7 0.0 2.2 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III Cathelicidins PF00666.15 001033509.2_29622001_3 - 5.3e-51 171.0 0.2 6.8e-51 170.7 0.2 1.1 1 0 0 1 1 1 1 Cathelicidin CAP18_C PF12153.6 001033509.2_29622001_3 - 2.3e-11 43.3 9.5 3.3e-11 42.8 9.5 1.2 1 0 0 1 1 1 1 LPS binding domain of CAP18 (C terminal) Spp-24 PF07448.9 001033509.2_29622001_3 - 0.00016 21.6 0.3 0.00027 20.9 0.3 1.3 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Cystatin PF00031.19 001033509.2_29622001_3 - 0.18 12.0 0.2 0.63 10.2 0.1 1.7 2 0 0 2 2 2 0 Cystatin domain Defensin_propep PF00879.16 001033906.1_39721001_1 - 1.7e-25 89.0 0.0 2.2e-25 88.6 0.0 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001033906.1_39721001_1 - 4.6e-08 33.3 13.7 6.2e-08 32.9 13.7 1.2 1 0 0 1 1 1 1 Mammalian defensin Defensin_beta PF00711.17 001032857.1_29621001_2 - 1.2e-12 47.4 9.4 1.7e-12 47.0 9.4 1.2 1 0 0 1 1 1 1 Beta defensin Defensin_beta_2 PF13841.4 001034195.1_29621001_1 - 9.5e-10 38.7 15.6 1.2e-09 38.3 15.6 1.1 1 0 0 1 1 1 1 Beta defensin Spp-24 PF07448.9 001009453.1_39522001_2 - 2.4e-39 133.2 3.2 3.6e-39 132.6 3.2 1.3 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Cathelicidins PF00666.15 001009453.1_39522001_2 - 7.9e-09 35.6 0.1 1.1e-08 35.1 0.1 1.2 1 0 0 1 1 1 1 Cathelicidin Cystatin PF00031.19 001009453.1_39522001_2 - 0.0012 19.0 0.0 0.0018 18.4 0.0 1.3 1 0 0 1 1 1 1 Cystatin domain Trypsin PF00089.24 214109.1_49822001_1 - 3.8e-70 236.0 5.2 4.5e-70 235.8 5.2 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 214109.1_49822001_1 - 2.5e-08 34.8 0.3 3.6e-08 34.3 0.3 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 214109.1_49822001_1 - 0.00052 20.2 0.3 0.0012 19.1 0.3 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Pro-rich PF15240.4 012632.1_45723001_1 - 3.3e-15 56.7 198.7 7.7e-09 36.0 96.1 3.0 1 1 1 2 2 2 2 Proline-rich VCX_VCY PF15231.4 012632.1_45723001_2 - 2.9 8.4 8.3 2.3 8.7 2.8 2.0 1 1 1 2 2 2 0 Variable charge X/Y family His_Phos_1 PF00300.20 001009163.1_39722001_1 - 7.8e-31 107.2 0.0 9.5e-24 84.0 0.0 2.0 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) LysM PF01476.18 001009163.1_39722001_1 - 0.0056 16.6 0.0 0.04 13.9 0.0 2.3 2 0 0 2 2 2 1 LysM domain Homeobox PF00046.27 001009767.1_39522001_1 - 3.2e-23 81.2 1.8 4.9e-23 80.6 1.8 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001009767.1_39522001_1 - 0.00022 20.9 0.1 0.00022 20.9 0.1 2.7 3 0 0 3 3 3 1 Homeobox KN domain Defensin_propep PF00879.16 001032863.1_29621001_1 - 2.9e-22 78.6 4.7 4.1e-22 78.1 4.7 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001032863.1_29621001_1 - 4e-08 33.5 18.7 5.7e-08 33.0 18.7 1.2 1 0 0 1 1 1 1 Mammalian defensin Reticulon PF02453.15 001034121.1_39725001_1 - 2.9e-44 150.6 9.8 3.9e-44 150.2 9.8 1.2 1 0 0 1 1 1 1 Reticulon DUF402 PF04167.11 001034121.1_39725001_1 - 0.12 12.4 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF402) Defensin_beta_2 PF13841.4 001032908.1_29621001_1 - 5.4e-09 36.3 11.8 7.3e-09 35.8 11.8 1.2 1 0 0 1 1 1 1 Beta defensin Defensin_big PF14862.4 001032908.1_29621001_1 - 6.4e-07 29.5 0.2 1e-06 28.8 0.2 1.3 1 0 0 1 1 1 1 Big defensin ubiquitin PF00240.21 001009735.1_39522001_2 - 7.6e-31 105.5 0.1 9.3e-21 73.2 0.0 2.1 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.6 001009735.1_39522001_2 - 2.7e-08 33.4 0.0 5.7e-06 25.9 0.0 2.1 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 001009735.1_39522001_2 - 0.011 16.0 0.1 6.9 7.1 0.0 3.0 2 1 0 2 2 2 0 Ubiquitin-like domain TUG-UBL1 PF11470.6 001009735.1_39522001_2 - 0.033 14.3 0.0 0.073 13.2 0.0 1.6 2 0 0 2 2 2 0 TUG ubiquitin-like domain Lac_bphage_repr PF06543.10 001009735.1_39522001_2 - 0.13 12.1 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Lactococcus bacteriophage repressor 7tm_1 PF00001.19 001032833.1_29623001_1 - 5e-46 157.0 11.9 6.1e-46 156.7 11.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001032833.1_29623001_1 - 4.4e-11 42.5 20.1 4.2e-08 32.7 13.7 2.5 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.7 001032833.1_29623001_1 - 0.0012 18.1 11.8 0.0012 18.1 11.8 2.5 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srx PF10328.7 001032833.1_29623001_1 - 0.0049 16.1 17.0 0.0049 16.1 17.0 2.0 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx XK-related PF09815.7 001033038.1_39723001_1 - 1.9e-85 286.6 30.7 1.9e-85 286.6 30.7 1.5 2 0 0 2 2 2 1 XK-related protein Metallophos PF00149.26 134367.1_45724001_2 - 7.4e-36 124.4 0.0 1.1e-35 123.8 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Cathelicidins PF00666.15 001009772.1_39522001_1 - 1.1e-52 176.4 1.0 1.4e-52 176.1 1.0 1.1 1 0 0 1 1 1 1 Cathelicidin Spp-24 PF07448.9 001009772.1_39522001_1 - 0.00018 21.4 0.6 0.00032 20.7 0.6 1.5 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Cystatin PF00031.19 001009772.1_39522001_1 - 0.0078 16.3 0.3 0.065 13.4 0.3 2.0 1 1 0 1 1 1 1 Cystatin domain p450 PF00067.20 001040218.1_29623001_1 - 9.9e-133 443.1 0.0 1.1e-132 442.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 7tm_1 PF00001.19 001040421.1_29622001_1 - 2.7e-10 39.8 25.3 1.5e-06 27.6 15.2 2.2 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001040421.1_29622001_1 - 9.2e-05 21.7 9.5 9.2e-05 21.7 9.5 2.2 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srbc PF10316.7 001040421.1_29622001_1 - 0.0011 18.4 2.8 0.0011 18.4 2.8 2.7 1 1 2 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srbc DUF1705 PF08019.10 001040421.1_29622001_1 - 0.016 15.0 2.1 0.016 15.0 2.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1705) TcpE PF12648.5 001040421.1_29622001_1 - 0.024 15.0 0.6 0.024 15.0 0.6 2.7 2 1 0 2 2 2 0 TcpE family Ferrochelatase PF00762.17 001038012.1_39723001_1 - 2.7e-109 365.0 0.0 3.2e-109 364.7 0.0 1.1 1 0 0 1 1 1 1 Ferrochelatase zf-C4H2 PF10146.7 001038012.1_39723001_3 - 0.0017 18.6 0.9 0.0032 17.6 0.9 1.4 1 0 0 1 1 1 1 Zinc finger-containing protein Defensin_propep PF00879.16 001032816.1_29621001_1 - 5e-22 77.9 4.6 7.2e-22 77.3 4.6 1.2 1 0 0 1 1 1 1 Defensin propeptide Paralemmin PF03285.13 001038645.2_49825001_2 - 7.2e-55 186.7 17.9 9.7e-54 183.0 17.9 2.4 1 1 0 1 1 1 1 Paralemmin Cob_adeno_trans PF01923.16 001038645.2_49825001_2 - 0.15 12.0 3.8 0.34 10.9 3.8 1.6 1 0 0 1 1 1 0 Cobalamin adenosyltransferase MGTL PF17059.3 001038645.2_49825001_2 - 0.27 11.0 1.5 0.84 9.4 1.5 1.8 1 0 0 1 1 1 0 MgtA leader peptide ADK PF00406.20 001038645.2_49825001_2 - 1.1 9.2 4.8 2.5 8.1 4.8 1.7 1 0 0 1 1 1 0 Adenylate kinase 7tm_1 PF00001.19 001034092.1_39723001_1 - 4.1e-61 206.4 5.9 5e-61 206.2 5.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001034092.1_39723001_1 - 0.0025 17.4 5.0 0.015 14.9 3.3 2.1 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001034092.1_39723001_1 - 0.022 14.0 6.7 0.045 13.0 6.7 1.7 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx DUF1385 PF07136.9 001034092.1_39723001_1 - 0.3 10.2 1.3 0.33 10.1 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1385) XK-related PF09815.7 001033036.1_39725001_2 - 1.2e-126 422.0 27.0 1.5e-126 421.7 27.0 1.1 1 0 0 1 1 1 1 XK-related protein UPF0139 PF03669.11 001001645.1_49822001_1 - 8.6e-48 160.0 1.2 1.3e-47 159.5 1.2 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) TFIIS_C PF01096.16 001071808.1_39721001_1 - 1e-15 57.2 4.9 1e-15 57.2 4.9 3.0 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) OrfB_Zn_ribbon PF07282.9 001071808.1_39721001_1 - 0.00043 20.0 9.3 0.012 15.4 0.2 2.6 2 1 0 2 2 2 2 Putative transposase DNA-binding domain DZR PF12773.5 001071808.1_39721001_1 - 0.0016 18.2 12.9 0.013 15.4 0.9 2.8 2 1 0 2 2 2 1 Double zinc ribbon zinc_ribbon_2 PF13240.4 001071808.1_39721001_1 - 0.0054 16.3 12.6 0.34 10.6 1.6 4.0 3 1 0 3 3 3 2 zinc-ribbon domain Mu-like_Com PF10122.7 001071808.1_39721001_1 - 0.006 15.9 3.0 0.87 9.0 0.2 2.3 2 0 0 2 2 2 2 Mu-like prophage protein Com zf-MYND PF01753.16 001071808.1_39721001_1 - 0.0078 16.2 0.7 0.73 9.8 0.0 2.7 2 2 0 2 2 2 1 MYND finger RNA_POL_M_15KD PF02150.14 001071808.1_39721001_1 - 0.01 15.5 0.5 0.01 15.5 0.5 3.1 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit Ogr_Delta PF04606.10 001071808.1_39721001_1 - 0.013 15.3 3.1 0.013 15.3 3.1 2.7 4 0 0 4 4 4 0 Ogr/Delta-like zinc finger Zn_Tnp_IS1595 PF12760.5 001071808.1_39721001_1 - 0.021 14.7 4.2 0.021 14.7 4.2 2.8 2 1 1 3 3 3 0 Transposase zinc-ribbon domain MqsA_antitoxin PF15731.3 001071808.1_39721001_1 - 0.048 13.6 2.2 4.4 7.3 0.4 2.3 2 1 0 2 2 2 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA IBR PF01485.19 001071808.1_39721001_1 - 0.071 13.2 10.1 0.11 12.5 0.3 2.7 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain DNA_RNApol_7kD PF03604.11 001071808.1_39721001_1 - 0.15 11.6 0.4 0.15 11.6 0.4 3.4 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit A2L_zn_ribbon PF08792.8 001071808.1_39721001_1 - 0.24 11.0 9.1 7.6 6.2 0.1 4.3 4 0 0 4 4 4 0 A2L zinc ribbon domain Lar_restr_allev PF14354.4 001071808.1_39721001_1 - 0.42 10.9 9.4 0.16 12.2 1.5 2.7 2 1 0 2 2 2 0 Restriction alleviation protein Lar DUF2318 PF10080.7 001071808.1_39721001_1 - 0.45 10.5 6.4 0.33 10.9 0.5 2.6 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) TF_Zn_Ribbon PF08271.10 001071808.1_39721001_1 - 0.5 9.8 15.5 1.6 8.2 0.1 4.5 3 1 1 4 4 4 0 TFIIB zinc-binding zinc_ribbon_4 PF13717.4 001071808.1_39721001_1 - 0.61 9.9 11.1 8.3 6.3 0.3 4.1 3 1 2 5 5 5 0 zinc-ribbon domain Fer4_2 PF12797.5 001071808.1_39721001_1 - 0.67 10.1 11.7 24 5.2 0.1 4.3 4 0 0 4 4 4 0 4Fe-4S binding domain zinc_ribbon_15 PF17032.3 001071808.1_39721001_1 - 0.93 10.1 9.1 10 6.8 2.7 3.2 2 1 0 2 2 2 0 zinc-ribbon family DUF3268 PF11672.6 001071808.1_39721001_1 - 1.4 9.2 5.1 0.34 11.1 1.2 1.9 3 0 0 3 3 2 0 zinc-finger-containing domain Rpr2 PF04032.14 001071808.1_39721001_1 - 1.7 8.9 7.4 27 5.1 7.2 2.3 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-TFIIB PF13453.4 001071808.1_39721001_1 - 2.5 7.4 7.3 0.75 9.0 1.2 3.0 3 1 0 3 3 3 0 Transcription factor zinc-finger zf-ribbon_3 PF13248.4 001071808.1_39721001_1 - 3.2 7.2 17.0 1.4 8.3 0.3 4.4 3 1 1 4 4 4 0 zinc-ribbon domain DUF3716 PF12511.6 001071808.1_39721001_1 - 3.6 7.6 12.9 0.06 13.3 3.8 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3716) UPF0547 PF10571.7 001071808.1_39721001_1 - 4.2 7.4 12.5 48 4.0 0.1 4.0 3 1 0 3 3 3 0 Uncharacterised protein family UPF0547 GFA PF04828.12 001071808.1_39721001_1 - 4.6 7.5 10.7 1.6 9.0 0.7 3.0 1 1 2 3 3 3 0 Glutathione-dependent formaldehyde-activating enzyme zf-C4_Topoisom PF01396.17 001071808.1_39721001_1 - 6.1 6.6 13.8 0.39 10.4 3.3 3.7 3 1 1 4 4 4 0 Topoisomerase DNA binding C4 zinc finger Ribosomal_L37e PF01907.17 001071808.1_39721001_1 - 8.3 6.5 11.2 17 5.6 3.3 3.6 3 1 0 3 3 3 0 Ribosomal protein L37e CpXC PF14353.4 001071808.1_39721001_1 - 8.8 6.3 8.3 1.5 8.7 1.5 2.7 2 2 1 3 3 3 0 CpXC protein Acyltransferase PF01553.19 001009746.1_39525001_2 - 9e-33 112.6 0.0 1.3e-32 112.1 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Oest_recep PF02159.13 001009746.1_39525001_3 - 0.35 11.2 1.4 0.91 9.9 1.4 1.6 1 0 0 1 1 1 0 Oestrogen receptor MFS_1 PF07690.14 173302.1_45724001_1 - 5.5e-31 107.6 22.5 2.8e-18 65.9 7.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 173302.1_45724001_1 - 1.3e-18 67.0 15.2 1.3e-18 67.0 15.2 1.5 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.12 173302.1_45724001_1 - 1.9e-05 24.0 10.9 3.2e-05 23.3 4.2 2.3 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB p450 PF00067.20 001040414.1_29624001_1 - 4.5e-132 440.9 0.1 5.1e-132 440.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3687 PF12459.6 001040414.1_29624001_1 - 0.17 11.3 1.0 0.58 9.6 1.0 1.9 1 0 0 1 1 1 0 D-Ala-teichoic acid biosynthesis protein Nitroreductase PF00881.22 214416.1_49823001_3 - 1.4e-20 73.9 0.0 2.3e-20 73.2 0.0 1.3 1 0 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.4 214416.1_49823001_3 - 6.8e-05 22.4 0.1 0.04 13.4 0.1 2.9 2 1 0 2 2 2 2 Putative TM nitroreductase Glycolytic PF00274.17 001009147.2_39724001_2 - 3e-182 604.9 0.0 3.5e-182 604.7 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I APOBEC_N PF08210.9 001032982.2_32322001_2 - 8.1e-30 103.9 3.4 1.2e-29 103.4 3.4 1.1 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001032982.2_32322001_2 - 6e-25 86.9 0.5 6e-25 86.9 0.5 1.8 2 0 0 2 2 2 1 APOBEC-like C-terminal domain Toxin-deaminase PF14424.4 001032982.2_32322001_2 - 0.00076 19.5 0.0 0.0011 19.0 0.0 1.2 1 0 0 1 1 1 1 The BURPS668_1122 family of deaminases dCMP_cyt_deam_1 PF00383.21 001032982.2_32322001_2 - 0.0022 17.7 0.0 0.0039 16.9 0.0 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Calpain_inhib PF00748.17 001009788.1_39526001_1 - 5.5e-103 340.6 122.5 1.3e-34 119.3 9.1 7.1 5 1 1 6 6 6 4 Calpain inhibitor Maf_N PF08383.9 001009788.1_39526001_1 - 0.011 15.4 0.3 2.8 7.7 0.1 2.7 2 0 0 2 2 2 0 Maf N-terminal region zf-CCHC_5 PF14787.4 001009788.1_39526001_1 - 0.91 9.1 6.5 6.9 6.3 0.1 3.5 3 0 0 3 3 3 0 GAG-polyprotein viral zinc-finger Pkinase_Tyr PF07714.15 001048163.1_22428001_1 - 3.8e-86 288.5 0.0 5.6e-86 287.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.22 001048163.1_22428001_1 - 8.7e-55 183.5 0.0 1.3e-32 112.1 0.0 2.3 2 0 0 2 2 2 2 Receptor L domain GF_recep_IV PF14843.4 001048163.1_22428001_1 - 9.9e-42 141.7 73.6 2e-38 131.0 25.5 3.7 2 1 1 3 3 3 1 Growth factor receptor domain IV Pkinase PF00069.23 001048163.1_22428001_1 - 1.1e-36 126.5 0.0 1.5e-36 126.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.18 001048163.1_22428001_1 - 2.1e-25 89.2 37.3 2.1e-25 89.2 37.3 4.1 2 1 0 2 2 2 1 Furin-like cysteine rich region APH PF01636.21 001048163.1_22428001_1 - 0.015 15.1 0.2 0.035 13.9 0.2 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Rifin_STEVOR PF02009.14 001048163.1_22428001_1 - 0.12 12.1 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Rifin/stevor family CBP_BcsF PF11120.6 001048163.1_22428001_1 - 0.41 10.6 4.2 0.22 11.4 1.5 1.9 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsF Acyltransferase PF01553.19 001009011.1_39722001_1 - 2.5e-42 143.5 0.0 3.4e-42 143.1 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase URO-D PF01208.15 001012341.1_39523001_3 - 1.7e-135 451.5 0.0 1.9e-135 451.4 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) CD34_antigen PF06365.10 214086.1_49826001_1 - 7.7e-67 224.8 0.0 1e-66 224.4 0.0 1.2 1 0 0 1 1 1 1 CD34/Podocalyxin family DUF4064 PF13273.4 214086.1_49826001_1 - 0.047 13.9 0.3 0.14 12.4 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) Cys_knot PF00007.20 001032928.1_29621001_1 - 1.8e-32 111.6 4.3 2.1e-32 111.4 4.3 1.1 1 0 0 1 1 1 1 Cystine-knot domain Hormone_3 PF00159.16 001032814.1_29621001_2 - 3.8e-19 68.4 1.4 6.2e-19 67.7 1.4 1.4 1 0 0 1 1 1 1 Pancreatic hormone peptide XK-related PF09815.7 001033035.1_39726001_2 - 3.1e-84 282.7 27.8 4.6e-84 282.1 27.8 1.2 1 0 0 1 1 1 1 XK-related protein Cathelicidins PF00666.15 001009787.1_39522001_1 - 8.5e-51 170.4 0.4 1e-50 170.1 0.4 1.1 1 0 0 1 1 1 1 Cathelicidin Spp-24 PF07448.9 001009787.1_39522001_1 - 9.8e-05 22.3 0.5 0.00016 21.7 0.5 1.3 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain MOEP19 PF16005.3 001168938.1_40421001_1 - 1.3e-40 137.1 0.1 1.9e-40 136.6 0.1 1.2 1 0 0 1 1 1 1 KH-like RNA-binding domain Defensin_propep PF00879.16 001082300.1_37921001_3 - 3.1e-20 72.1 5.1 5.1e-20 71.4 5.1 1.3 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001082300.1_37921001_3 - 3.4e-09 36.9 12.7 6.6e-09 36.0 12.7 1.5 1 0 0 1 1 1 1 Mammalian defensin CSD PF00313.20 001082785.1_37923001_2 - 4.7e-26 90.3 0.5 7.9e-26 89.6 0.5 1.4 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.9 001082785.1_37923001_2 - 0.022 14.3 0.0 0.052 13.1 0.0 1.5 1 0 0 1 1 1 0 Ribonuclease B OB domain PSP94 PF05825.9 001112650.1_40422001_3 - 3e-47 159.0 13.1 4e-47 158.6 13.1 1.2 1 0 0 1 1 1 1 Beta-microseminoprotein (PSP-94) TILa PF12714.5 001112650.1_40422001_3 - 0.025 14.4 10.8 0.052 13.4 10.8 1.7 1 1 0 1 1 1 0 TILa domain VWC PF00093.16 001112650.1_40422001_3 - 0.11 12.7 13.3 0.35 11.1 13.3 1.9 1 1 0 1 1 1 0 von Willebrand factor type C domain Calpain_inhib PF00748.17 001082270.1_37928001_1 - 2.4e-106 351.5 111.5 3.6e-34 118.0 17.5 6.5 4 2 2 6 6 6 6 Calpain inhibitor Maf_N PF08383.9 001082270.1_37928001_1 - 0.018 14.7 1.2 5.7 6.7 0.1 2.6 2 0 0 2 2 2 0 Maf N-terminal region PDEase_I PF00233.17 001130826.1_29626001_1 - 2.9e-78 262.7 7.6 5.4e-78 261.9 7.6 1.5 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.24 001130826.1_29626001_1 - 9e-26 90.8 0.9 7.4e-16 58.8 0.0 3.4 3 0 0 3 3 3 2 GAF domain GAF_2 PF13185.4 001130826.1_29626001_1 - 7e-22 78.1 0.1 1.8e-08 34.6 0.0 3.6 3 0 0 3 3 3 3 GAF domain GAF_3 PF13492.4 001130826.1_29626001_1 - 1e-12 48.4 0.0 1.8e-06 28.1 0.0 3.1 3 0 0 3 3 3 2 GAF domain Secretogranin_V PF05281.9 001105287.1_49822001_3 - 1.2e-12 47.8 0.3 1.3e-09 37.9 0.1 2.1 1 1 1 2 2 2 2 Neuroendocrine protein 7B2 precursor (Secretogranin V) Uricase PF01014.16 001128073.1_37923001_2 - 1.7e-58 196.5 1.7 1.1e-35 122.7 0.0 2.1 2 0 0 2 2 2 2 Uricase FolB PF02152.16 001128073.1_37923001_2 - 0.11 12.9 0.1 0.2 12.1 0.1 1.4 1 0 0 1 1 1 0 Dihydroneopterin aldolase COX1 PF00115.18 001128073.1_37923001_3 - 1.8 7.2 7.9 0.041 12.6 1.4 1.5 2 0 0 2 2 2 0 Cytochrome C and Quinol oxidase polypeptide I HSP70 PF00012.18 001132670.1_43528001_2 - 5.1e-110 368.3 0.1 3.3e-78 263.3 0.0 2.0 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.11 001132670.1_43528001_2 - 6.2e-13 48.1 0.1 8.3e-10 37.9 0.0 2.7 3 0 0 3 3 3 2 MreB/Mbl protein StbA PF06406.9 001132670.1_43528001_2 - 0.047 12.8 0.0 0.082 12.0 0.0 1.3 1 0 0 1 1 1 0 StbA protein BcrAD_BadFG PF01869.18 001132670.1_43528001_2 - 0.047 13.0 0.2 7.7 5.8 0.0 2.8 2 1 0 3 3 3 0 BadF/BadG/BcrA/BcrD ATPase family Defensin_propep PF00879.16 001082298.1_37921001_2 - 1e-19 70.5 3.1 1.4e-19 70.0 3.1 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001082298.1_37921001_2 - 3.9e-08 33.6 16.9 3.9e-08 33.6 16.9 1.9 2 0 0 2 2 2 1 Mammalian defensin FBA_1 PF07734.11 001082298.1_37921001_3 - 0.048 13.4 0.0 0.07 12.9 0.0 1.2 1 0 0 1 1 1 0 F-box associated Crust_neuro_H PF03858.11 001082298.1_37921001_3 - 0.1 13.3 0.0 0.18 12.5 0.0 1.4 1 0 0 1 1 1 0 Crustacean neurohormone H TPD52 PF04201.13 001082360.1_37925001_3 - 5.9e-74 246.9 9.6 8.3e-74 246.5 9.6 1.2 1 0 0 1 1 1 1 Tumour protein D52 family Spc7 PF08317.9 001082360.1_37925001_3 - 0.053 12.2 7.0 0.082 11.6 7.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Uds1 PF15456.4 001082360.1_37925001_3 - 0.057 13.4 7.8 0.092 12.8 7.8 1.3 1 0 0 1 1 1 0 Up-regulated During Septation IncA PF04156.12 001082360.1_37925001_3 - 0.078 12.6 6.7 0.14 11.8 6.7 1.3 1 0 0 1 1 1 0 IncA protein ERM PF00769.17 001082360.1_37925001_3 - 0.14 11.8 8.8 0.2 11.3 8.8 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family HsbA PF12296.6 001082360.1_37925001_3 - 0.15 12.4 6.5 0.093 13.0 1.0 2.2 1 1 1 2 2 2 0 Hydrophobic surface binding protein A Cnn_1N PF07989.9 001082360.1_37925001_3 - 0.17 11.9 4.1 0.39 10.7 4.1 1.6 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 Occludin_ELL PF07303.11 001082360.1_37925001_3 - 0.18 12.4 2.3 1.5 9.4 0.2 2.3 1 1 1 2 2 2 0 Occludin homology domain TBPIP PF07106.11 001082360.1_37925001_3 - 1 9.0 9.3 2 8.0 6.0 2.0 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) AAA_13 PF13166.4 001082360.1_37925001_3 - 2.5 6.5 9.7 2 6.8 1.3 2.0 1 1 1 2 2 2 0 AAA domain WXG100 PF06013.10 001082360.1_37925001_3 - 3.4 7.8 7.9 11 6.2 0.4 2.5 1 1 2 3 3 3 0 Proteins of 100 residues with WXG tRNA_Me_trans PF03054.14 001132098.1_43524001_3 - 4e-143 476.4 0.0 4.7e-143 476.1 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase ThiI PF02568.12 001132098.1_43524001_3 - 2.6e-06 27.0 0.0 5.3e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) NAD_synthase PF02540.15 001132098.1_43524001_3 - 3.8e-05 22.8 0.0 0.00011 21.2 0.0 1.7 2 0 0 2 2 2 1 NAD synthase Asn_synthase PF00733.19 001132098.1_43524001_3 - 0.00044 19.9 0.0 0.0006 19.5 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase QueC PF06508.11 001132098.1_43524001_3 - 0.013 14.8 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC Asn_synthase PF00733.19 001132997.1_43525001_1 - 9.2e-85 285.3 0.7 1.2e-47 163.2 0.1 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.4 001132997.1_43525001_1 - 3.4e-25 88.2 0.0 5.8e-25 87.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.4 001132997.1_43525001_1 - 1.8e-19 70.2 0.0 4e-19 69.0 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.6 001132997.1_43525001_1 - 1.9e-06 27.4 0.0 3.6e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Aluminium induced protein tRNA_Me_trans PF03054.14 001132997.1_43525001_1 - 0.011 14.5 0.0 0.016 13.8 0.0 1.3 1 0 0 1 1 1 0 tRNA methyl transferase Cloacin_immun PF03513.12 001132997.1_43525001_1 - 0.057 13.6 0.1 0.15 12.3 0.1 1.7 1 0 0 1 1 1 0 Cloacin immunity protein NAD_synthase PF02540.15 001132997.1_43525001_1 - 0.069 12.1 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 NAD synthase QueC PF06508.11 001132997.1_43525001_1 - 0.12 11.7 0.0 0.23 10.8 0.0 1.5 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC ITAM PF02189.13 001077423.1_29621001_1 - 1.4e-21 75.4 5.5 2.7e-06 27.4 0.1 3.4 3 0 0 3 3 3 3 Immunoreceptor tyrosine-based activation motif TCR_zetazeta PF11628.6 001077423.1_29621001_1 - 7.8e-18 63.7 1.0 1.2e-17 63.1 1.0 1.3 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 zeta chain NTP_transferase PF00483.21 001169098.1_40423001_1 - 2.6e-29 102.4 0.0 3.5e-29 102.0 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.5 001169098.1_40423001_1 - 6.3e-09 36.2 0.0 9.4e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.22 001169098.1_40423001_1 - 8.4e-08 31.5 4.7 1.8e-06 27.3 0.4 3.2 3 0 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.3 001169098.1_40423001_1 - 0.0075 14.3 0.1 0.011 13.8 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) DUF4268 PF14088.4 001109817.1_37922001_1 - 0.023 14.4 0.0 0.034 13.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4268) Abhydrolase_2 PF02230.14 001109817.1_37922001_3 - 2.6e-89 298.6 0.0 2.9e-89 298.4 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.11 001109817.1_37922001_3 - 2.8e-06 27.2 0.0 5.8e-05 22.9 0.0 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 001109817.1_37922001_3 - 3.1e-06 26.5 0.0 0.1 11.7 0.0 3.0 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.18 001109817.1_37922001_3 - 6.9e-06 25.8 0.2 6.3e-05 22.6 0.2 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001109817.1_37922001_3 - 0.00016 22.2 0.0 0.0002 21.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Cutinase PF01083.20 001109817.1_37922001_3 - 0.0012 18.7 0.0 0.0025 17.7 0.0 1.6 1 1 0 1 1 1 1 Cutinase FSH1 PF03959.11 001109817.1_37922001_3 - 0.0041 16.7 0.0 0.018 14.6 0.0 2.0 1 1 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.16 001109817.1_37922001_3 - 0.0047 16.4 0.0 0.0078 15.7 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family DUF2974 PF11187.6 001109817.1_37922001_3 - 0.006 16.0 0.0 0.012 15.1 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2974) Esterase PF00756.18 001109817.1_37922001_3 - 0.047 13.2 0.2 0.078 12.5 0.2 1.5 1 1 0 1 1 1 0 Putative esterase Lipase_3 PF01764.23 001109817.1_37922001_3 - 0.061 13.1 0.0 0.091 12.5 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) LRR_8 PF13855.4 001109131.1_45729001_3 - 6.3e-37 125.0 71.7 5.6e-09 35.5 3.5 9.7 3 2 6 11 11 11 8 Leucine rich repeat PP2C PF00481.19 001109131.1_45729001_3 - 7.9e-28 97.6 0.0 1.2e-27 97.0 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_4 PF12799.5 001109131.1_45729001_3 - 1.3e-26 92.0 73.8 7.4e-08 32.4 2.7 12.0 4 3 11 15 15 15 14 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 001109131.1_45729001_3 - 9.1e-06 25.2 56.5 0.15 12.0 0.7 14.6 15 0 0 15 15 15 5 Leucine Rich repeat PH PF00169.27 001109131.1_45729001_3 - 0.019 15.3 0.0 0.045 14.1 0.0 1.6 1 0 0 1 1 1 0 PH domain LRR_1 PF00560.31 001109131.1_45729001_3 - 0.046 14.1 63.1 11 6.8 0.1 16.6 16 3 1 17 17 17 0 Leucine Rich Repeat Acetyltransf_2 PF00797.15 001082186.1_37923001_2 - 1.5e-91 306.4 0.3 1.9e-91 306.0 0.3 1.2 1 0 0 1 1 1 1 N-acetyltransferase Amidinotransf PF02274.15 001131196.2_43525001_1 - 1.2e-09 37.7 0.0 4.9e-05 22.6 0.0 2.2 2 0 0 2 2 2 2 Amidinotransferase Mtc PF03820.15 001126350.1_39522001_1 - 2.3e-151 503.1 1.5 2.5e-151 502.9 1.5 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier BSD PF03909.15 001126350.1_39522001_1 - 0.045 13.6 0.0 1.2 9.1 0.0 2.3 2 0 0 2 2 2 0 BSD domain IDO PF01231.16 001077483.1_29623001_3 - 5.3e-123 410.9 0.0 6.8e-123 410.5 0.0 1.1 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase DUF1864 PF08933.9 001077483.1_29623001_3 - 0.00098 17.8 0.0 0.0032 16.1 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF1864) Tmemb_14 PF03647.11 001135545.2_43522001_2 - 5.2e-28 97.5 10.7 7.1e-28 97.1 10.7 1.2 1 0 0 1 1 1 1 Transmembrane proteins 14C ThrE PF06738.10 001135545.2_43522001_2 - 5.7 6.1 6.8 7.4 5.7 6.8 1.1 1 0 0 1 1 1 0 Putative threonine/serine exporter GCFC PF07842.10 001099965.1_37926001_1 - 1.7e-97 326.2 17.6 2.9e-97 325.5 14.7 2.1 2 0 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein TIP_N PF12457.6 001099965.1_37926001_1 - 3.4e-30 104.4 8.5 3.4e-30 104.4 8.5 2.1 3 0 0 3 3 3 1 Tuftelin interacting protein N terminal G-patch PF01585.21 001099965.1_37926001_1 - 1.5e-16 59.9 4.5 2.9e-16 58.9 4.5 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.5 001099965.1_37926001_1 - 0.00016 21.6 1.1 0.00045 20.1 1.1 1.8 1 0 0 1 1 1 1 G-patch domain SNURF PF07192.9 001110815.1_39723001_1 - 6.4e-45 150.7 6.1 1e-44 150.0 6.1 1.3 1 0 0 1 1 1 1 SNURF/RPN4 protein LSM PF01423.20 001110815.1_39723001_3 - 1.1e-19 69.7 0.1 1.6e-19 69.2 0.1 1.2 1 0 0 1 1 1 1 LSM domain Glycolytic PF00274.17 001133694.1_43524001_1 - 2.6e-173 575.5 0.2 3e-173 575.3 0.2 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I An_peroxidase PF03098.13 001110449.1_22426001_1 - 7.6e-55 186.3 0.1 5.8e-47 160.3 0.0 2.2 1 1 1 2 2 2 2 Animal haem peroxidase EGF PF00008.25 001110449.1_22426001_1 - 0.00013 22.0 11.8 0.00013 22.0 11.8 2.0 2 0 0 2 2 2 1 EGF-like domain Pkinase_Tyr PF07714.15 001114952.1_29626001_1 - 1.9e-84 282.9 0.0 2.4e-84 282.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001114952.1_29626001_1 - 3.1e-38 131.5 0.0 5.4e-37 127.4 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain F5_F8_type_C PF00754.23 001114952.1_29626001_1 - 4.6e-21 75.1 0.0 7.2e-21 74.5 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain Kinase-like PF14531.4 001114952.1_29626001_1 - 0.046 12.9 0.0 0.067 12.4 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Lamprin PF06403.9 001114952.1_29626001_1 - 0.075 12.9 0.4 0.17 11.7 0.4 1.5 1 0 0 1 1 1 0 Lamprin Tachykinin PF02202.14 001101698.1_37922001_1 - 8.7e-10 37.4 1.3 0.00093 18.7 1.0 2.5 2 0 0 2 2 2 2 Tachykinin family FBPase PF00316.18 001082128.1_37923001_2 - 4.8e-74 247.9 0.2 6.2e-74 247.5 0.2 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.23 001082128.1_37923001_2 - 9.7e-05 21.9 0.0 0.00018 21.0 0.0 1.3 1 0 0 1 1 1 1 Inositol monophosphatase family ACT_7 PF13840.4 001082128.1_37923001_2 - 0.11 12.2 0.2 0.23 11.2 0.2 1.5 1 0 0 1 1 1 0 ACT domain DUF776 PF05604.9 001133802.2_43524001_3 - 9.9e-94 312.7 15.5 1.4e-93 312.2 15.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF776) DUF872 PF05915.10 001132565.1_43523001_1 - 1.5e-17 63.7 0.2 2.6e-17 63.0 0.2 1.4 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF872) SelK_SelG PF10961.6 001114877.1_39722001_1 - 8.4e-29 99.9 0.1 1.7e-28 98.9 0.1 1.5 1 0 0 1 1 1 1 Selenoprotein SelK_SelG Colipase_C PF02740.12 001082243.1_37921001_2 - 7.2e-28 96.4 6.2 1.2e-27 95.6 6.2 1.4 1 0 0 1 1 1 1 Colipase, C-terminal domain Colipase PF01114.16 001082243.1_37921001_2 - 1.4e-26 91.7 6.0 2.8e-26 90.8 6.0 1.5 1 0 0 1 1 1 1 Colipase, N-terminal domain Prokineticin PF06607.9 001082243.1_37921001_2 - 0.19 11.9 8.5 0.5 10.6 8.5 1.7 1 1 0 1 1 1 0 Prokineticin Myelin_PLP PF01275.17 001082328.1_37922001_1 - 6.1e-101 337.1 16.1 6.9e-101 336.9 16.1 1.0 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) IL1 PF00340.17 001122940.1_37922001_1 - 6.4e-30 103.2 1.9 9.6e-30 102.6 1.9 1.3 1 0 0 1 1 1 1 Interleukin-1 / 18 SGL PF08450.10 001082003.1_37923001_2 - 2.7e-78 262.8 0.1 3.2e-78 262.6 0.1 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region NHL PF01436.19 001082003.1_37923001_2 - 0.041 13.8 0.0 0.091 12.7 0.0 1.6 1 0 0 1 1 1 0 NHL repeat Reg_prop PF07494.9 001082003.1_37923001_2 - 0.061 13.4 0.0 0.41 10.9 0.0 2.5 2 0 0 2 2 2 0 Two component regulator propeller Acyl-CoA_dh_C PF12806.5 001082003.1_37923001_2 - 0.12 12.4 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 Acetyl-CoA dehydrogenase C-terminal like C1q PF00386.19 001085438.1_22422001_1 - 6.6e-40 136.1 1.2 8.1e-40 135.8 1.2 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.16 001085438.1_22422001_1 - 6.3e-11 41.7 28.3 2.3e-09 36.8 28.3 2.2 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) SYS1 PF09801.7 001168734.1_40426001_3 - 8.6e-52 175.0 3.8 1.6e-51 174.1 3.8 1.5 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network NOA36 PF06524.10 001132482.1_43524001_3 - 2.9e-161 535.9 46.0 3.8e-161 535.5 46.0 1.1 1 0 0 1 1 1 1 NOA36 protein GCFC PF07842.10 001080152.1_39726001_2 - 4e-100 334.9 16.8 6.6e-100 334.1 13.8 2.2 2 0 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein TIP_N PF12457.6 001080152.1_39726001_2 - 1.6e-29 102.2 10.2 1.6e-29 102.2 10.2 2.1 2 0 0 2 2 2 1 Tuftelin interacting protein N terminal G-patch PF01585.21 001080152.1_39726001_2 - 1.7e-16 59.7 4.5 3.2e-16 58.8 4.5 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.5 001080152.1_39726001_2 - 0.00019 21.3 1.1 0.00049 20.0 1.1 1.7 1 0 0 1 1 1 1 G-patch domain Fer2 PF00111.25 001108002.1_45722001_3 - 4e-10 39.4 0.1 6.2e-10 38.8 0.1 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain eIF-1a PF01176.17 001145052.1_29622001_2 - 3e-21 74.9 0.1 4.2e-21 74.4 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Cystatin PF00031.19 001082706.1_37922001_2 - 6.1e-27 93.6 0.0 8.4e-27 93.2 0.0 1.2 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.3 001082706.1_37922001_2 - 0.00037 20.7 0.0 0.00051 20.2 0.0 1.2 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor CARD_2 PF16739.3 001097429.1_49824001_1 - 7e-20 70.7 0.0 1e-19 70.2 0.0 1.2 1 0 0 1 1 1 1 Caspase recruitment domain SKG6 PF08693.8 001097429.1_49824001_1 - 0.4 10.0 2.0 0.72 9.2 2.0 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Peptidase_M2 PF01401.16 001123070.1_49825001_1 - 4.4e-234 778.2 1.4 5.3e-234 778.0 1.4 1.0 1 0 0 1 1 1 1 Angiotensin-converting enzyme Collectrin PF16959.3 001123070.1_49825001_1 - 3.1e-73 244.4 0.0 6.5e-73 243.4 0.0 1.5 1 0 0 1 1 1 1 Renal amino acid transporter Glycophorin_A PF01102.16 001123070.1_49825001_1 - 0.052 13.7 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Glycophorin A EphA2_TM PF14575.4 001123070.1_49825001_1 - 0.076 13.7 0.0 0.18 12.5 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4440 PF14534.4 001123070.1_49825001_1 - 0.12 12.6 0.3 26 5.1 0.0 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF4440) PetG PF02529.13 001123070.1_49825001_1 - 2.3 8.0 4.5 0.71 9.6 0.9 2.0 2 0 0 2 2 2 0 Cytochrome B6-F complex subunit 5 Defensin_beta_2 PF13841.4 001129791.1_39721001_1 - 2e-09 37.6 4.2 2.7e-09 37.2 4.2 1.2 1 0 0 1 1 1 1 Beta defensin ST7 PF04184.10 001168665.1_29624001_1 - 0 1073.7 1.9 0 1073.5 1.9 1.0 1 0 0 1 1 1 1 ST7 protein TPR_6 PF13174.4 001168665.1_29624001_1 - 0.00061 20.1 0.0 0.0033 17.8 0.0 2.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.15 001168665.1_29624001_1 - 0.0051 16.7 0.2 4.8 7.4 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat Clathrin PF00637.18 001168665.1_29624001_1 - 0.06 13.1 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Region in Clathrin and VPS TPR_19 PF14559.4 001168665.1_29624001_1 - 0.14 12.5 4.9 0.41 11.0 0.5 3.3 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.26 001168665.1_29624001_1 - 1.4 8.7 3.4 1.1e+02 2.8 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.4 001168665.1_29624001_1 - 2.3 9.1 8.2 14 6.6 0.0 4.6 3 2 2 5 5 5 0 Tetratricopeptide repeat Zip PF02535.20 001131045.1_49825001_1 - 9.4e-80 268.2 19.8 3.7e-79 266.2 5.8 2.1 2 0 0 2 2 2 2 ZIP Zinc transporter Presenilin PF01080.15 001078667.1_49824001_3 - 1.5e-165 550.7 9.7 1.5e-165 550.7 9.7 2.0 2 0 0 2 2 2 1 Presenilin VIT1 PF01988.17 001078667.1_49824001_3 - 0.062 13.0 0.2 5.3 6.7 0.0 2.4 2 0 0 2 2 2 0 VIT family LRRC37AB_C PF14914.4 001078667.1_49824001_3 - 0.75 9.6 4.5 9.6 6.0 0.2 2.8 2 1 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain Defensin_beta PF00711.17 001129784.1_39721001_1 - 3.4e-05 23.6 6.5 4.7e-05 23.2 6.5 1.1 1 0 0 1 1 1 1 Beta defensin Defensin_3 PF08131.9 001129784.1_39721001_1 - 0.98 9.5 10.0 13 5.9 10.0 2.1 1 1 0 1 1 1 0 Defensin-like peptide family SCAMP PF04144.11 001133174.1_43527001_2 - 9.2e-68 227.8 18.1 1.5e-67 227.2 18.1 1.3 1 0 0 1 1 1 1 SCAMP family Defensin_beta_2 PF13841.4 001129768.1_39721001_1 - 2.5e-07 30.9 16.0 3.2e-07 30.6 16.0 1.1 1 0 0 1 1 1 1 Beta defensin Auts2 PF15336.4 001082302.2_37921001_2 - 0.03 14.3 0.2 0.038 14.0 0.2 1.1 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein SAA PF00277.16 001082302.2_37921001_3 - 2.6e-53 178.6 4.4 3.2e-53 178.4 4.4 1.1 1 0 0 1 1 1 1 Serum amyloid A protein TGFb_propeptide PF00688.16 001101031.2_49824001_1 - 5.5e-53 180.1 0.3 8.1e-53 179.5 0.3 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001101031.2_49824001_1 - 8.2e-34 116.5 0.5 1.6e-33 115.6 0.5 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain Tnp_DNA_bind PF14706.4 001101031.2_49824001_1 - 0.032 13.9 0.1 3.5 7.4 0.0 2.6 2 0 0 2 2 2 0 Transposase DNA-binding Defensin_beta_2 PF13841.4 001129762.1_39721001_1 - 1.5e-06 28.4 9.4 2.7e-06 27.6 9.4 1.4 1 0 0 1 1 1 1 Beta defensin PAN_4 PF14295.4 001129762.1_39721001_1 - 6.7 6.6 12.5 15 5.4 11.8 1.8 1 1 1 2 2 2 0 PAN domain Spectrin PF00435.19 001131762.1_43525001_3 - 0.099 13.0 0.1 0.17 12.2 0.1 1.3 1 0 0 1 1 1 0 Spectrin repeat MORN PF02493.18 001081998.1_37925001_2 - 2.2e-35 118.3 62.6 8.6e-07 28.4 0.2 8.6 8 0 0 8 8 8 8 MORN repeat CALCOCO1 PF07888.9 001131665.1_43527001_2 - 1.5e-242 806.4 33.3 1.5e-242 806.4 33.3 1.6 2 0 0 2 2 2 1 Calcium binding and coiled-coil domain (CALCOCO1) like Vps23_core PF09454.8 001131665.1_43527001_2 - 0.073 12.9 3.9 0.045 13.6 1.3 2.1 2 0 0 2 2 2 0 Vps23 core domain Pox_A_type_inc PF04508.10 001131665.1_43527001_2 - 0.13 12.0 0.1 0.13 12.0 0.1 3.8 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat Reo_sigmaC PF04582.10 001131665.1_43527001_2 - 0.96 8.7 17.7 0.024 13.9 3.1 3.5 1 1 1 3 3 3 0 Reovirus sigma C capsid protein Rootletin PF15035.4 001131665.1_43527001_2 - 3.3 7.6 71.5 3.6 7.5 20.2 3.7 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion zf-HIT PF04438.14 001131210.1_43526001_1 - 5e-07 29.4 10.8 1e-06 28.3 10.8 1.6 1 0 0 1 1 1 1 HIT zinc finger 7tm_1 PF00001.19 001128489.1_49823001_1 - 2.5e-53 180.9 7.8 3.1e-53 180.6 7.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001128489.1_49823001_1 - 7e-09 35.3 7.8 2.2e-08 33.7 7.8 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 001128489.1_49823001_1 - 2.2e-08 33.6 2.2 4e-08 32.8 2.2 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.7 001128489.1_49823001_1 - 9.1e-05 21.8 1.1 9.1e-05 21.8 1.1 2.0 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001128489.1_49823001_1 - 0.11 12.0 6.8 0.2 11.2 6.6 1.7 1 1 0 1 1 1 0 Olfactory receptor 7TM_GPCR_Srw PF10324.7 001128489.1_49823001_1 - 0.22 10.6 11.7 0.58 9.3 10.7 2.2 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srw Defensin_beta_2 PF13841.4 001129783.1_39721001_1 - 2.7e-07 30.8 8.7 3.6e-07 30.4 8.7 1.2 1 0 0 1 1 1 1 Beta defensin DSPc PF00782.18 001132852.1_43527001_2 - 2e-06 27.5 0.0 3.7e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 001132852.1_43527001_2 - 1.5e-05 24.5 0.0 0.00017 21.1 0.0 1.9 1 1 1 2 2 2 1 Protein-tyrosine phosphatase SNURF PF07192.9 001082714.1_37921001_1 - 8.8e-46 153.4 6.1 1.1e-45 153.1 6.1 1.1 1 0 0 1 1 1 1 SNURF/RPN4 protein SP_C-Propep PF08999.8 001082322.1_37922001_3 - 9.7e-57 188.6 1.7 1.5e-56 188.0 1.7 1.3 1 0 0 1 1 1 1 Surfactant protein C, N terminal propeptide BRICHOS PF04089.12 001082322.1_37922001_3 - 8.3e-16 57.7 0.0 1.3e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 BRICHOS domain PDGF PF00341.15 001136099.1_29623001_1 - 1.2e-23 83.0 6.4 1.2e-23 83.0 6.4 3.0 2 1 1 3 3 3 1 PDGF/VEGF domain CXCXC PF03128.12 001136099.1_29623001_1 - 2.6e-08 33.6 61.2 0.00064 19.8 4.9 8.7 8 0 0 8 8 8 4 CXCXC repeat SGL PF08450.10 001134030.2_43524001_3 - 3.1e-76 256.1 0.1 3.7e-76 255.8 0.1 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region NHL PF01436.19 001134030.2_43524001_3 - 0.065 13.2 0.0 0.17 11.9 0.0 1.8 1 0 0 1 1 1 0 NHL repeat Acyl-CoA_dh_C PF12806.5 001134030.2_43524001_3 - 0.068 13.2 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Acetyl-CoA dehydrogenase C-terminal like Reg_prop PF07494.9 001134030.2_43524001_3 - 0.079 13.1 0.0 0.34 11.1 0.0 2.1 2 0 0 2 2 2 0 Two component regulator propeller zf-C4 PF00105.16 001082726.1_37924001_3 - 1.3e-28 99.1 14.3 1.3e-28 99.1 14.3 1.8 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001082726.1_37924001_3 - 4e-25 88.5 0.8 4e-25 88.5 0.8 2.0 2 1 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor MHC_II_beta PF00969.17 001134293.1_29622001_1 - 1.2e-29 102.1 1.5 2.2e-29 101.3 1.5 1.4 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001134293.1_29622001_1 - 5.7e-27 93.9 0.1 1.2e-26 92.9 0.0 1.6 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001134293.1_29622001_1 - 0.0003 21.2 0.0 0.00074 19.9 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001134293.1_29622001_1 - 0.00066 19.7 0.0 0.0013 18.8 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Marek_A PF02124.13 001134293.1_29622001_1 - 0.00069 19.4 0.1 0.0011 18.7 0.1 1.4 1 0 0 1 1 1 1 Marek's disease glycoprotein A Ig_2 PF13895.4 001134293.1_29622001_1 - 0.0014 18.8 0.1 0.0089 16.2 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.10 001134293.1_29622001_1 - 0.0057 16.6 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain PPDK_N PF01326.17 001134293.1_29622001_1 - 0.084 12.0 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain MORN PF02493.18 001081996.1_37929001_1 - 3e-31 105.3 74.4 1.1e-07 31.2 0.7 8.7 8 0 0 8 8 8 8 MORN repeat Alanine_zipper PF11839.6 001081996.1_37929001_1 - 4.5 7.5 16.7 11 6.2 16.7 1.6 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein MtN3_slv PF03083.14 001112628.1_40423001_1 - 2.8e-56 187.4 7.5 7.6e-28 96.2 0.2 2.3 2 0 0 2 2 2 2 Sugar efflux transporter for intercellular exchange Defensin_beta_2 PF13841.4 001113568.1_39721001_3 - 1.4e-08 35.0 13.2 1.7e-08 34.6 13.2 1.1 1 0 0 1 1 1 1 Beta defensin TBD PF12845.5 001133797.1_43525001_2 - 5.1e-21 74.2 0.1 1.5e-20 72.7 0.1 1.9 1 0 0 1 1 1 1 TBD domain Cnn_1N PF07989.9 001133797.1_43525001_2 - 0.019 15.0 3.8 0.019 15.0 3.8 2.7 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 Prefoldin_2 PF01920.18 001133797.1_43525001_2 - 0.88 9.4 18.6 3.6 7.5 1.1 3.4 3 0 0 3 3 3 0 Prefoldin subunit DUF342 PF03961.11 001133797.1_43525001_2 - 4.7 5.6 19.4 0.056 11.9 4.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF342) Protamine_P1 PF00260.18 001143822.1_29621001_2 - 6.5e-12 45.2 78.0 9.3e-12 44.7 78.0 1.2 1 0 0 1 1 1 1 Protamine P1 DUF2650 PF10853.6 001143822.1_29621001_2 - 3.9 7.2 6.4 0.65 9.7 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2650) DUF2346 PF09803.7 001097466.2_49821001_2 - 3.3e-28 97.9 2.6 5.6e-28 97.1 2.6 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2346) AAA_23 PF13476.4 001097466.2_49821001_2 - 0.047 14.1 0.8 0.053 13.9 0.8 1.1 1 0 0 1 1 1 0 AAA domain Defensin_propep PF00879.16 001082299.1_37921001_3 - 2.9e-20 72.2 5.1 4.8e-20 71.5 5.1 1.4 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001082299.1_37921001_3 - 2.3e-10 40.7 13.9 4.6e-10 39.7 13.9 1.5 1 0 0 1 1 1 1 Mammalian defensin Defensin_beta PF00711.17 001129794.1_39721001_1 - 0.00067 19.5 7.9 0.001 18.9 7.9 1.3 1 0 0 1 1 1 1 Beta defensin UCH PF00443.27 001133865.1_43529001_1 - 1.4e-58 198.3 5.6 1.9e-58 197.8 5.6 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 001133865.1_43529001_1 - 5.2e-31 108.3 8.2 6.9e-31 107.9 8.2 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Agouti PF05039.10 001134303.1_39523001_2 - 5.1e-30 103.9 14.7 7.6e-30 103.3 14.7 1.3 1 0 0 1 1 1 1 Agouti protein Toxin_9 PF02819.13 001134303.1_39523001_2 - 0.13 12.4 12.8 0.22 11.7 12.8 1.3 1 0 0 1 1 1 0 Spider toxin Chordopox_A30L PF06015.10 001134303.1_39523001_2 - 0.2 11.4 2.3 0.36 10.6 2.3 1.4 1 0 0 1 1 1 0 Chordopoxvirus A30L protein PAC1 PF16094.3 001169084.1_40422001_1 - 5.9e-132 439.0 1.6 7.1e-132 438.7 1.6 1.0 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 Bromodomain PF00439.23 001001182.3_32929001_2 - 1.1e-20 73.4 0.0 2.4e-20 72.2 0.0 1.7 1 0 0 1 1 1 1 Bromodomain PHD PF00628.27 001001182.3_32929001_2 - 1.4e-11 44.0 9.4 4.3e-11 42.4 9.4 1.9 1 0 0 1 1 1 1 PHD-finger WSD PF15613.4 001001182.3_32929001_2 - 7.3e-11 42.3 0.1 5e-07 30.0 0.0 5.4 7 0 0 7 7 7 2 Williams-Beuren syndrome DDT (WSD), D-TOX E motif MBD PF01429.17 001001182.3_32929001_2 - 9.2e-11 41.2 0.0 2.3e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 Methyl-CpG binding domain DDT PF02791.15 001001182.3_32929001_2 - 2.5e-09 37.2 0.3 9.7e-09 35.3 0.3 2.1 1 0 0 1 1 1 1 DDT domain DUF2457 PF10446.7 001001182.3_32929001_2 - 0.0015 17.7 23.9 0.0015 17.7 23.9 6.2 5 2 1 6 6 6 1 Protein of unknown function (DUF2457) WHIM1 PF15612.4 001001182.3_32929001_2 - 0.04 13.4 0.0 0.09 12.2 0.0 1.6 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 RWD PF05773.20 001131624.2_43526001_3 - 7.2e-15 55.2 0.1 1.2e-14 54.5 0.1 1.4 1 0 0 1 1 1 1 RWD domain DUF1115 PF06544.10 001131624.2_43526001_3 - 0.00081 19.4 0.6 0.019 15.0 0.6 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF1115) PH PF00169.27 001134613.1_45726001_1 - 8.9e-06 26.0 0.2 3.4e-05 24.2 0.1 2.0 2 0 0 2 2 2 1 PH domain PH_11 PF15413.4 001134613.1_45726001_1 - 0.00036 20.8 0.0 0.00073 19.8 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PDZ_2 PF13180.4 001134613.1_45726001_1 - 0.05 13.8 0.0 0.15 12.3 0.0 1.7 2 0 0 2 2 2 0 PDZ domain FAM110_N PF14161.4 001133233.1_43527001_3 - 1.9e-46 156.8 2.6 3.4e-46 156.0 2.6 1.4 1 0 0 1 1 1 1 Centrosome-associated N terminus FAM110_C PF14160.4 001133233.1_43527001_3 - 4.5e-33 114.5 0.3 1.1e-32 113.2 0.3 1.7 1 0 0 1 1 1 1 Centrosome-associated C terminus CASP_C PF08172.10 001135473.1_43526001_3 - 6e-58 196.0 1.8 6e-58 196.0 1.8 5.2 2 2 2 4 4 4 1 CASP C terminal DUF2205 PF10224.7 001135473.1_43526001_3 - 0.0024 17.7 0.7 0.0024 17.7 0.7 6.6 4 2 3 7 7 7 1 Predicted coiled-coil protein (DUF2205) NPV_P10 PF05531.10 001135473.1_43526001_3 - 0.021 15.1 2.1 0.021 15.1 2.1 5.8 5 1 1 6 6 6 0 Nucleopolyhedrovirus P10 protein NDUF_B8 PF05821.9 001135473.1_43526001_3 - 0.075 12.8 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) HOOK PF05622.10 001135473.1_43526001_3 - 3.6 5.5 72.9 0.021 12.9 42.0 3.5 2 1 1 3 3 3 0 HOOK protein IRF-3 PF10401.7 001135797.1_29623001_3 - 1e-49 168.7 0.0 1.5e-49 168.1 0.0 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 IRF PF00605.15 001135797.1_29623001_3 - 7.2e-35 119.3 0.0 1.1e-34 118.7 0.0 1.3 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor dCMP_cyt_deam_1 PF00383.21 001132159.1_43527001_2 - 2.6e-18 65.6 0.5 8e-09 35.2 0.0 2.6 2 1 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.4 001132159.1_43527001_2 - 2.3e-11 43.4 0.3 0.0001 21.9 0.1 2.4 2 0 0 2 2 2 2 MafB19-like deaminase Defensin_propep PF00879.16 001171013.1_37921001_1 - 2.7e-23 81.9 2.7 2.7e-23 81.9 2.7 1.4 2 0 0 2 2 2 1 Defensin propeptide Defensin_1 PF00323.17 001171013.1_37921001_1 - 4.3e-10 39.8 12.7 5.6e-10 39.4 12.7 1.2 1 0 0 1 1 1 1 Mammalian defensin GCFC PF07842.10 001133272.1_43526001_3 - 2.1e-100 335.8 17.1 3.3e-100 335.1 14.1 2.1 2 0 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein TIP_N PF12457.6 001133272.1_43526001_3 - 1.6e-29 102.2 10.2 1.6e-29 102.2 10.2 2.0 2 0 0 2 2 2 1 Tuftelin interacting protein N terminal G-patch PF01585.21 001133272.1_43526001_3 - 1.7e-16 59.7 4.5 3.2e-16 58.9 4.5 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.5 001133272.1_43526001_3 - 0.0002 21.3 1.1 0.00048 20.0 1.1 1.7 1 0 0 1 1 1 1 G-patch domain GCFC PF07842.10 001097609.1_32326001_3 - 2.1e-99 332.5 16.7 5.8e-99 331.1 14.1 2.2 2 0 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein TIP_N PF12457.6 001097609.1_32326001_3 - 4.1e-26 91.2 8.8 4.1e-26 91.2 8.8 2.1 3 0 0 3 3 3 1 Tuftelin interacting protein N terminal G-patch PF01585.21 001097609.1_32326001_3 - 1.8e-16 59.7 4.8 3.4e-16 58.8 4.8 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.5 001097609.1_32326001_3 - 6.1e-05 22.9 1.1 0.00018 21.4 1.1 1.8 1 0 0 1 1 1 1 G-patch domain E1_DerP2_DerF2 PF02221.13 001130432.1_29621001_1 - 1.6e-15 57.6 0.2 1.9e-15 57.4 0.2 1.1 1 0 0 1 1 1 1 ML domain Cathelicidins PF00666.15 001082305.1_37922001_1 - 6.7e-51 170.7 0.5 8.7e-51 170.3 0.5 1.1 1 0 0 1 1 1 1 Cathelicidin CAP18_C PF12153.6 001082305.1_37922001_1 - 6.5e-10 38.7 11.7 8.8e-10 38.2 11.7 1.2 1 0 0 1 1 1 1 LPS binding domain of CAP18 (C terminal) Spp-24 PF07448.9 001082305.1_37922001_1 - 0.002 18.2 0.5 0.0032 17.5 0.5 1.3 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Cystatin PF00031.19 001082305.1_37922001_1 - 0.016 15.3 0.9 0.1 12.7 0.9 1.9 1 1 0 1 1 1 0 Cystatin domain ATP-synt_D PF01813.15 001082368.1_37923001_2 - 1.4e-75 253.3 9.1 1.9e-75 252.9 9.1 1.1 1 0 0 1 1 1 1 ATP synthase subunit D MatE PF01554.16 001109819.1_37925001_2 - 6.1e-60 201.4 29.6 3.2e-30 104.8 10.2 2.6 2 0 0 2 2 2 2 MatE RPAP2_Rtr1 PF04181.11 001132339.1_43527001_2 - 2.6e-23 82.0 0.4 9.5e-23 80.2 0.4 2.1 1 0 0 1 1 1 1 Rtr1/RPAP2 family Cytochrom_B558a PF05038.11 001082099.1_37922001_1 - 2.1e-98 327.2 0.6 2.4e-98 327.0 0.6 1.0 1 0 0 1 1 1 1 Cytochrome Cytochrome b558 alpha-subunit Cg6151-P PF10233.7 001082099.1_37922001_1 - 3.7e-05 23.9 3.0 0.0034 17.6 1.1 2.1 2 0 0 2 2 2 2 Uncharacterized conserved protein CG6151-P TNFR_c6 PF00020.16 001123003.1_39523001_1 - 1.9e-15 56.9 50.8 1.1e-09 38.4 11.6 3.5 3 0 0 3 3 3 3 TNFR/NGFR cysteine-rich region Death PF00531.20 001123003.1_39523001_1 - 3.3e-12 46.3 0.0 5.7e-12 45.5 0.0 1.4 1 0 0 1 1 1 1 Death domain Rifin_STEVOR PF02009.14 001123003.1_39523001_1 - 7.7e-06 25.9 0.6 3.3e-05 23.8 0.0 2.0 2 0 0 2 2 2 1 Rifin/stevor family DUF4381 PF14316.4 001123003.1_39523001_1 - 0.0013 18.9 0.0 0.0025 18.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) P12 PF12669.5 001123003.1_39523001_1 - 0.0089 16.3 0.8 0.0089 16.3 0.8 4.3 3 1 0 3 3 1 1 Virus attachment protein p12 family DUF912 PF06024.10 001123003.1_39523001_1 - 0.016 15.4 0.0 0.042 14.0 0.0 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) TMEM154 PF15102.4 001123003.1_39523001_1 - 0.022 14.5 0.1 0.058 13.2 0.1 1.7 1 1 0 1 1 1 0 TMEM154 protein family Stn1_C PF12659.5 001123003.1_39523001_1 - 0.036 13.9 0.2 0.063 13.1 0.2 1.3 1 0 0 1 1 1 0 Telomere capping C-terminal wHTH CcmH PF03918.12 001123003.1_39523001_1 - 0.043 13.0 0.4 0.11 11.6 0.0 1.9 2 0 0 2 2 2 0 Cytochrome C biogenesis protein CoA_binding_3 PF13727.4 001123003.1_39523001_1 - 0.048 13.5 0.1 0.14 12.0 0.1 1.8 2 0 0 2 2 2 0 CoA-binding domain SRTM1 PF15872.3 001123003.1_39523001_1 - 0.086 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 EphA2_TM PF14575.4 001123003.1_39523001_1 - 0.09 13.5 0.0 0.25 12.1 0.0 1.9 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain RHIM PF12721.5 001130132.1_39725001_1 - 3.8e-13 49.6 7.3 3.8e-13 49.6 7.3 3.7 3 1 0 3 3 3 1 RIP homotypic interaction motif TIR_2 PF13676.4 001130132.1_39725001_1 - 0.027 14.7 0.0 0.067 13.4 0.0 1.7 1 0 0 1 1 1 0 TIR domain eIF-5_eIF-2B PF01873.15 001082398.2_37923001_2 - 2.4e-41 140.2 0.2 4.3e-41 139.3 0.2 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 MHC_I PF00129.16 001114274.1_49823001_1 - 4.9e-18 65.2 0.1 7.5e-18 64.6 0.1 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001114274.1_49823001_1 - 2.3e-13 50.3 0.0 4.7e-13 49.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001114274.1_49823001_1 - 0.00048 20.6 0.5 0.0054 17.2 0.5 2.5 1 1 1 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 001114274.1_49823001_1 - 0.00059 20.0 0.3 0.0024 18.1 0.3 2.1 1 1 0 1 1 1 1 Immunoglobulin domain MHC_I PF00129.16 153761.3_32923001_3 - 4.3e-32 111.0 0.0 6e-32 110.5 0.0 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 MHC_I_3 PF16497.3 153761.3_32923001_3 - 3.7e-12 46.0 0.0 8.2e-12 44.9 0.0 1.5 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 153761.3_32923001_3 - 7.5e-08 32.6 0.4 2.2e-07 31.1 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 153761.3_32923001_3 - 0.0074 16.7 0.7 0.038 14.5 0.0 2.5 2 1 1 3 3 3 1 Immunoglobulin domain BiPBP_C PF06832.10 153761.3_32923001_3 - 0.032 14.1 0.2 0.44 10.5 0.0 2.5 3 0 0 3 3 3 0 Penicillin-Binding Protein C-terminus Family C2-set_2 PF08205.10 153761.3_32923001_3 - 0.15 12.0 2.3 0.29 11.1 0.0 2.5 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain EOS1 PF12326.6 001135546.1_43523001_1 - 0.22 11.3 5.9 0.36 10.6 5.9 1.4 1 0 0 1 1 1 0 N-glycosylation protein Afi1 PF07792.10 001135546.1_43523001_2 - 3.3 8.1 14.8 4.7 7.6 14.8 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF2052 PF09747.7 001135546.1_43523001_2 - 8.7 6.3 18.3 11 6.0 18.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) URO-D PF01208.15 001135546.1_43523001_3 - 2.4e-133 444.4 0.0 2.9e-133 444.2 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) RNA_pol_Rpc4 PF05132.12 001135546.1_43523001_3 - 0.02 15.2 16.9 0.03 14.7 16.9 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 Neur_chan_memb PF02932.14 001135546.1_43523001_3 - 0.026 14.5 2.3 0.031 14.2 2.3 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DDHD PF02862.15 001135546.1_43523001_3 - 0.055 13.5 8.5 0.07 13.1 8.5 1.2 1 0 0 1 1 1 0 DDHD domain Defensin_beta_2 PF13841.4 001079928.1_39721001_1 - 6.4e-07 29.6 9.8 9.6e-07 29.0 9.8 1.3 1 0 0 1 1 1 1 Beta defensin Defensin_3 PF08131.9 001079928.1_39721001_1 - 2 8.6 9.5 2.1 8.5 7.7 2.0 1 1 1 2 2 2 0 Defensin-like peptide family Trypsin PF00089.24 027097.1_32922001_1 - 5e-68 229.1 1.5 5.8e-68 228.9 1.5 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 027097.1_32922001_1 - 4.8e-06 26.8 0.3 2.8e-05 24.3 0.3 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 027097.1_32922001_1 - 1.8e-05 25.5 0.1 2.9e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain Abhydrolase_2 PF02230.14 001131978.1_43525001_1 - 7.4e-87 290.6 0.0 9.4e-87 290.2 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.18 001131978.1_43525001_1 - 0.00022 20.8 0.5 0.0021 17.6 0.5 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 001131978.1_43525001_1 - 0.00023 20.4 0.0 0.18 10.9 0.0 2.8 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.11 001131978.1_43525001_1 - 0.00033 20.4 0.1 0.0017 18.1 0.0 1.8 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001131978.1_43525001_1 - 0.00075 20.0 0.0 0.001 19.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Cutinase PF01083.20 001131978.1_43525001_1 - 0.0094 15.8 0.0 0.021 14.6 0.0 1.5 1 0 0 1 1 1 1 Cutinase DUF2974 PF11187.6 001131978.1_43525001_1 - 0.039 13.4 0.0 0.066 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) FSH1 PF03959.11 001131978.1_43525001_1 - 0.068 12.7 0.0 0.23 10.9 0.0 1.7 1 1 0 1 1 1 0 Serine hydrolase (FSH1) CD4-extracel PF09191.8 001129902.1_39523001_1 - 2e-47 159.9 6.3 4.2e-47 158.9 0.6 3.5 3 1 0 3 3 3 1 CD4, extracellular C2-set PF05790.13 001129902.1_39523001_1 - 4.8e-37 125.9 15.0 7.4e-20 70.8 0.5 4.6 4 0 0 4 4 4 2 Immunoglobulin C2-set domain ig PF00047.23 001129902.1_39523001_1 - 2.6e-26 91.5 7.6 9e-18 64.1 0.1 4.3 4 0 0 4 4 4 2 Immunoglobulin domain Ig_3 PF13927.4 001129902.1_39523001_1 - 2.5e-17 63.1 5.0 7.4e-07 29.6 0.1 4.4 4 0 0 4 4 4 2 Immunoglobulin domain Tcell_CD4_C PF12104.6 001129902.1_39523001_1 - 8.8e-17 60.6 9.2 1.8e-16 59.6 9.2 1.5 1 0 0 1 1 1 1 T cell CD4 receptor C terminal region V-set PF07686.15 001129902.1_39523001_1 - 1.1e-15 57.6 3.8 1.4e-10 41.1 0.1 3.7 2 1 1 3 3 3 3 Immunoglobulin V-set domain I-set PF07679.14 001129902.1_39523001_1 - 2.2e-14 53.1 4.4 1.5e-06 28.0 0.2 4.7 3 1 1 4 4 4 3 Immunoglobulin I-set domain Ig_2 PF13895.4 001129902.1_39523001_1 - 2e-12 47.2 6.4 7.9e-05 22.8 0.3 4.5 2 2 2 4 4 4 2 Immunoglobulin domain Receptor_2B4 PF11465.6 001129902.1_39523001_1 - 0.00011 22.2 2.0 0.00033 20.7 0.4 2.5 2 1 1 3 3 3 1 Natural killer cell receptor 2B4 Ig_5 PF16681.3 001129902.1_39523001_1 - 0.00041 20.6 2.5 0.28 11.5 0.0 3.9 4 1 0 4 4 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 001129902.1_39523001_1 - 0.00086 19.2 1.1 4.2 7.4 0.0 3.9 5 0 0 5 5 5 2 Izumo-like Immunoglobulin domain Herpes_gE PF02480.14 001129902.1_39523001_1 - 0.0028 16.4 0.0 0.83 8.2 0.0 2.8 2 1 0 2 2 2 2 Alphaherpesvirus glycoprotein E P_proprotein PF01483.18 001129902.1_39523001_1 - 0.011 15.6 1.1 0.08 12.9 0.3 2.7 2 1 1 3 3 3 0 Proprotein convertase P-domain Sp38 PF07354.10 001129902.1_39523001_1 - 0.06 12.1 0.1 1.3 7.7 0.0 2.2 2 0 0 2 2 2 0 Zona-pellucida-binding protein (Sp38) V-set_CD47 PF08204.9 001129902.1_39523001_1 - 0.063 13.1 0.1 0.89 9.4 0.1 2.5 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain DUF3277 PF11681.6 001129902.1_39523001_1 - 0.092 12.5 0.4 0.52 10.1 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3277) C1-set PF07654.13 001129902.1_39523001_1 - 0.098 13.0 3.4 0.79 10.1 0.0 3.0 3 0 0 3 3 2 0 Immunoglobulin C1-set domain Glycolytic PF00274.17 001144833.1_39724001_3 - 5.7e-187 620.4 0.0 6.7e-187 620.2 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I FTZ PF03867.12 001144833.1_39724001_3 - 0.09 12.2 0.6 0.18 11.2 0.6 1.4 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region SEEK1 PF15357.4 001128140.1_39721001_1 - 2.5e-98 326.0 9.1 2.8e-98 325.9 9.1 1.0 1 0 0 1 1 1 1 Psoriasis susceptibility 1 candidate 1 BAT2_N PF07001.9 001114957.1_29629001_1 - 6.7e-71 238.6 10.6 6.7e-71 238.6 10.6 4.9 4 2 2 6 6 6 1 BAT2 N-terminus Metallophos PF00149.26 001082323.1_37923001_1 - 1.6e-39 136.4 0.1 2.1e-39 136.0 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.3 001082323.1_37923001_1 - 0.0014 18.9 1.5 0.002 18.4 0.6 1.8 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Acyltransf_C PF16076.3 001133935.1_43529001_2 - 3.8e-25 87.7 0.2 6.6e-25 86.9 0.2 1.4 1 0 0 1 1 1 1 Acyltransferase C-terminus Acyltransferase PF01553.19 001133935.1_43529001_2 - 8.4e-14 51.2 0.0 1.4e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Zfx_Zfy_act PF04704.11 001145069.1_29626001_1 - 2e-148 493.7 20.1 2e-148 493.7 20.1 1.5 1 1 0 1 1 1 1 Zfx / Zfy transcription activation region zf-C2H2 PF00096.24 001145069.1_29626001_1 - 6.6e-40 133.3 117.0 1e-05 25.6 2.1 13.4 13 0 0 13 13 13 13 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001145069.1_29626001_1 - 4.9e-37 124.6 125.9 3.5e-08 33.4 1.2 14.0 14 0 0 14 14 14 11 Zinc-finger double domain zf-C2H2_4 PF13894.4 001145069.1_29626001_1 - 4.8e-29 98.4 112.4 0.00013 22.3 0.9 13.5 13 0 0 13 13 13 13 C2H2-type zinc finger zf-H2C2_5 PF13909.4 001145069.1_29626001_1 - 4e-21 74.3 116.2 4.3e-07 29.4 5.4 12.3 13 1 0 13 13 13 9 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.6 001145069.1_29626001_1 - 2.6e-10 40.2 78.8 0.035 14.3 0.0 12.4 13 0 0 13 13 13 6 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 001145069.1_29626001_1 - 6.6e-08 33.1 48.8 0.033 14.8 2.4 7.3 5 1 2 7 7 7 6 zinc-ribbon family zf-met PF12874.5 001145069.1_29626001_1 - 0.0015 18.7 69.7 0.36 11.1 0.0 11.3 12 0 0 12 12 12 7 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 001145069.1_29626001_1 - 0.0021 17.8 2.5 0.0021 17.8 2.5 10.4 13 0 0 13 13 13 6 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001145069.1_29626001_1 - 0.0094 15.6 75.8 0.021 14.5 0.2 10.0 12 0 0 12 12 12 6 zinc-finger C2H2-type Metallophos PF00149.26 001131311.1_43525001_3 - 4.5e-13 50.0 0.0 7.8e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.5 001131311.1_43525001_3 - 2.9e-05 24.2 0.0 0.0012 19.0 0.0 2.2 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain Defensin_beta_2 PF13841.4 001129770.1_39721001_1 - 4e-08 33.5 13.0 5.8e-08 33.0 13.0 1.2 1 0 0 1 1 1 1 Beta defensin DUF837 PF05769.9 001132638.1_43523001_2 - 5.8e-66 221.7 18.5 7.1e-66 221.5 18.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF837) DUF4250 PF14056.4 001132638.1_43523001_2 - 0.25 11.2 1.5 0.45 10.4 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4250) Herpes_BLRF2 PF05812.10 001132638.1_43523001_2 - 0.39 10.7 4.4 1.1 9.3 0.4 2.3 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein Fib_alpha PF08702.8 001132638.1_43523001_2 - 4.5 7.3 11.2 5.6 7.0 1.7 2.4 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family OmpH PF03938.12 001132638.1_43523001_2 - 8.2 6.3 18.6 0.9 9.4 6.6 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) zf-C2HC_2 PF13913.4 001134190.1_43525001_3 - 3.2e-07 30.0 3.6 3.2e-07 30.0 3.6 2.2 2 0 0 2 2 2 1 zinc-finger of a C2HC-type Insulin PF00049.16 001204361.1_29622001_3 - 0.00012 22.8 1.0 0.00049 20.9 1.0 1.9 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family Paralemmin PF03285.13 001205006.1_08023001_1 - 1.2e-114 383.0 15.3 1.2e-114 383.0 15.3 1.6 2 0 0 2 2 2 1 Paralemmin CALCOCO1 PF07888.9 001205006.1_08023001_1 - 0.0013 17.3 13.5 0.0025 16.3 13.5 1.4 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like DUF4472 PF14739.4 001205006.1_08023001_1 - 0.071 13.7 17.4 1.1 9.8 6.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) Prominin PF05478.9 001205006.1_08023001_1 - 0.74 7.6 3.8 1 7.1 3.8 1.2 1 0 0 1 1 1 0 Prominin PspB PF06667.10 001205006.1_08023001_1 - 2.6 8.0 6.0 2.7 8.0 3.4 2.3 1 1 1 2 2 2 0 Phage shock protein B V_ATPase_I PF01496.17 001205006.1_08023001_1 - 3 5.5 7.4 4.3 5.0 7.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FlaC_arch PF05377.9 001205006.1_08023001_1 - 6.7 7.1 11.3 0.67 10.3 5.8 2.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) B12D PF06522.9 001253776.1_08021001_1 - 2e-35 120.3 0.0 2.3e-35 120.1 0.0 1.0 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit Hormone_1 PF00103.18 001290347.1_08022001_1 - 5e-46 157.0 0.1 5.9e-46 156.8 0.1 1.0 1 0 0 1 1 1 1 Somatotropin hormone family Trp_leader1 PF08055.9 001290347.1_08022001_1 - 0.1 12.2 2.1 0.27 10.8 2.1 1.8 1 0 0 1 1 1 0 Tryptophan leader peptide DUF2181 PF10223.7 001163627.1_32923001_2 - 3.2e-98 327.9 0.2 4.1e-98 327.5 0.2 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2181) 7tm_1 PF00001.19 001185041.1_08023001_1 - 2e-51 174.7 23.4 7.4e-51 172.8 23.8 1.8 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001185041.1_08023001_1 - 2.1e-09 37.0 21.4 2.6e-09 36.7 21.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx UPF0233 PF06781.10 001185041.1_08023001_1 - 0.61 10.0 3.0 1.1 9.3 0.0 2.7 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0233) Arm PF00514.21 001246433.1_39725001_3 - 1.6e-87 285.1 4.8 2.6e-11 43.0 0.0 8.7 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.18 001246433.1_39725001_3 - 4e-31 107.1 4.0 2.8e-30 104.4 5.1 1.9 2 0 0 2 2 1 1 Importin beta binding domain Arm_3 PF16186.3 001246433.1_39725001_3 - 1.5e-24 85.1 2.4 3e-24 84.2 2.4 1.5 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_EZ PF13513.4 001246433.1_39725001_3 - 6.2e-21 74.3 0.3 1.4e-06 28.5 0.0 5.3 3 2 3 6 6 6 3 HEAT-like repeat HEAT_2 PF13646.4 001246433.1_39725001_3 - 4.9e-12 45.9 0.1 0.0093 16.2 0.0 5.7 2 1 4 6 6 6 3 HEAT repeats HEAT PF02985.20 001246433.1_39725001_3 - 8.8e-09 34.7 0.5 0.13 12.4 0.0 6.2 6 0 0 6 6 6 2 HEAT repeat V-ATPase_H_C PF11698.6 001246433.1_39725001_3 - 6e-05 23.0 0.3 0.2 11.6 0.1 3.2 3 1 1 4 4 4 2 V-ATPase subunit H Adaptin_N PF01602.18 001246433.1_39725001_3 - 0.00052 18.6 0.0 0.0026 16.3 0.0 2.2 1 1 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.5 001246433.1_39725001_3 - 0.0019 18.1 0.0 0.33 10.8 0.0 3.8 2 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 SEN1_N PF12726.5 001246433.1_39725001_3 - 0.016 13.3 0.1 38 2.2 0.0 3.8 4 0 0 4 4 4 0 SEN1 N terminal DUF3554 PF12074.6 001246433.1_39725001_3 - 0.035 13.2 0.0 0.078 12.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3554) ParcG PF10274.7 001246433.1_39725001_3 - 0.15 12.0 0.3 0.94 9.4 0.2 2.2 1 1 1 2 2 2 0 Parkin co-regulated protein Sulfotransfer_3 PF13469.4 001246467.1_39724001_2 - 1.3e-55 189.0 0.0 1.8e-55 188.6 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.25 001246467.1_39724001_2 - 2.1e-08 33.8 0.1 9e-08 31.8 0.1 1.9 1 1 0 1 1 1 1 Sulfotransferase domain Ank_2 PF12796.5 001204919.1_08029001_3 - 6.2e-150 488.1 36.7 4e-19 68.9 0.6 12.3 3 3 9 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001204919.1_08029001_3 - 1.9e-119 388.5 17.3 9.1e-10 38.8 0.1 16.0 8 3 7 17 17 17 16 Ankyrin repeats (many copies) Ank PF00023.28 001204919.1_08029001_3 - 3.4e-112 362.3 50.9 5e-08 32.9 0.0 24.6 24 0 0 24 24 24 23 Ankyrin repeat Ank_3 PF13606.4 001204919.1_08029001_3 - 1.9e-102 322.6 28.8 6.4e-05 22.9 0.0 25.5 25 0 0 25 25 25 23 Ankyrin repeat Ank_5 PF13857.4 001204919.1_08029001_3 - 7.7e-98 318.7 46.6 5.4e-08 32.9 0.0 20.9 5 3 15 21 21 21 20 Ankyrin repeats (many copies) KH_1 PF00013.27 001204919.1_08029001_3 - 1.1e-14 53.9 0.6 2.9e-14 52.5 0.6 1.8 1 0 0 1 1 1 1 KH domain MHC_I PF00129.16 001048045.2_45723001_1 - 4.8e-72 241.1 0.1 6.5e-72 240.7 0.1 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001048045.2_45723001_1 - 1.4e-15 57.4 0.0 2.7e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain C2-set_2 PF08205.10 001048045.2_45723001_1 - 0.002 18.1 0.2 0.014 15.3 0.1 2.1 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001048045.2_45723001_1 - 0.0087 16.1 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain MHC_I_3 PF16497.3 001048045.2_45723001_1 - 0.043 13.1 0.0 0.057 12.8 0.0 1.3 1 0 0 1 1 1 0 MHC-I family domain KRTAP PF11759.6 001193399.1_39522001_2 - 2.4e-05 24.6 85.7 4.1e-05 23.9 59.4 2.1 1 1 1 2 2 2 2 Keratin-associated matrix C2-set PF05790.13 001257217.1_08023001_1 - 3.9e-12 46.0 0.5 8.3e-12 45.0 0.5 1.6 1 0 0 1 1 1 1 Immunoglobulin C2-set domain V-set PF07686.15 001257217.1_08023001_1 - 1.6e-10 41.0 0.0 7.5e-10 38.8 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.4 001257217.1_08023001_1 - 0.0012 19.0 2.3 0.0018 18.5 1.4 1.8 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 001257217.1_08023001_1 - 0.0024 17.7 2.6 0.038 13.9 0.3 2.8 1 1 1 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001257217.1_08023001_1 - 0.0063 17.0 2.0 2.6 8.6 0.6 2.7 2 0 0 2 2 2 2 Immunoglobulin domain Receptor_2B4 PF11465.6 001257217.1_08023001_1 - 0.039 14.0 0.1 0.086 12.9 0.1 1.6 1 0 0 1 1 1 0 Natural killer cell receptor 2B4 EphA2_TM PF14575.4 001257217.1_08023001_1 - 0.064 13.9 0.0 0.13 13.0 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF1191 PF06697.10 001257217.1_08023001_1 - 0.15 11.1 0.0 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) RnaseA PF00074.18 001270924.1_08025001_1 - 1.2e-39 135.4 6.3 2.4e-39 134.5 6.3 1.5 1 0 0 1 1 1 1 Pancreatic ribonuclease ACPS PF01648.18 001171189.1_29625001_1 - 2e-17 63.2 0.2 1e-16 60.9 0.1 2.0 2 0 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily Ig_2 PF13895.4 001199068.1_39522001_1 - 2.9e-16 59.4 0.0 2.6e-07 30.8 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001199068.1_39522001_1 - 6.2e-10 39.4 0.0 5.3e-06 26.8 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001199068.1_39522001_1 - 2.3e-06 27.5 0.2 0.0005 20.0 0.0 2.8 3 1 0 3 3 3 2 Immunoglobulin domain ubiquitin PF00240.21 001195756.1_29622001_2 - 1.4e-34 117.5 0.3 1.9e-34 117.1 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.15 001195756.1_29622001_2 - 7.7e-33 112.0 12.3 1.5e-32 111.1 12.3 1.5 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.6 001195756.1_29622001_2 - 9.1e-17 60.5 0.4 1.6e-16 59.8 0.4 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 001195756.1_29622001_2 - 7.9e-06 26.1 0.1 2.6e-05 24.5 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 001195756.1_29622001_2 - 0.0077 16.2 0.0 0.015 15.2 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 001195756.1_29622001_2 - 0.081 13.4 0.1 0.1 13.0 0.1 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Tmemb_185A PF10269.7 001242325.1_08029001_1 - 1.6e-58 198.2 28.4 2.2e-58 197.8 28.4 1.2 1 0 0 1 1 1 1 Transmembrane Fragile-X-F protein WD40 PF00400.30 001270719.1_08024001_1 - 7.3e-12 45.5 5.4 0.00077 20.1 0.0 6.4 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001270719.1_08024001_1 - 0.005 17.0 0.0 2.1 8.6 0.0 3.0 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain SRF-TF PF00319.16 001205200.1_08023001_1 - 3.9e-23 80.5 0.3 5.8e-23 80.0 0.3 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) BST2 PF16716.3 001161666.1_29622001_1 - 3.1e-35 120.5 6.8 5.1e-35 119.8 6.8 1.3 1 0 0 1 1 1 1 Bone marrow stromal antigen 2 MAD PF05557.11 001161666.1_29622001_1 - 0.00019 19.8 4.3 0.00023 19.6 4.3 1.0 1 0 0 1 1 1 1 Mitotic checkpoint protein CALCOCO1 PF07888.9 001161666.1_29622001_1 - 0.0016 16.9 2.5 0.002 16.7 2.5 1.0 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like CENP-F_leu_zip PF10473.7 001161666.1_29622001_1 - 0.0025 17.7 3.5 0.0027 17.6 2.3 1.6 1 1 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SlyX PF04102.10 001161666.1_29622001_1 - 0.0041 17.6 3.8 0.0064 16.9 0.2 2.2 1 1 1 2 2 2 1 SlyX ATG16 PF08614.9 001161666.1_29622001_1 - 0.0042 17.2 7.4 0.0084 16.2 7.4 1.5 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) Bap31 PF05529.10 001161666.1_29622001_1 - 0.0057 16.2 2.4 0.0057 16.2 2.4 1.5 2 0 0 2 2 1 1 B-cell receptor-associated protein 31-like NRBF2 PF08961.8 001161666.1_29622001_1 - 0.0091 15.5 0.5 0.012 15.1 0.5 1.2 1 0 0 1 1 1 1 Nuclear receptor-binding factor 2, autophagy regulator Filament PF00038.19 001161666.1_29622001_1 - 0.012 15.1 4.5 0.018 14.5 4.4 1.3 1 1 0 1 1 1 0 Intermediate filament protein DUF2353 PF09789.7 001161666.1_29622001_1 - 0.013 14.9 1.0 0.016 14.5 1.0 1.2 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) CASP_C PF08172.10 001161666.1_29622001_1 - 0.017 14.3 0.7 0.022 14.0 0.7 1.3 1 0 0 1 1 1 0 CASP C terminal Lebercilin PF15619.4 001161666.1_29622001_1 - 0.02 14.4 2.9 0.03 13.8 2.9 1.3 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease TMF_DNA_bd PF12329.6 001161666.1_29622001_1 - 0.024 14.5 0.8 0.024 14.5 0.8 1.5 2 0 0 2 2 1 0 TATA element modulatory factor 1 DNA binding TMF_TATA_bd PF12325.6 001161666.1_29622001_1 - 0.03 14.4 3.7 0.07 13.2 3.5 1.6 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Tropomyosin_1 PF12718.5 001161666.1_29622001_1 - 0.031 14.3 2.4 0.031 14.3 2.4 1.7 1 1 1 2 2 2 0 Tropomyosin like Spc7 PF08317.9 001161666.1_29622001_1 - 0.038 12.7 4.4 0.047 12.4 4.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein EMP24_GP25L PF01105.22 001161666.1_29622001_1 - 0.039 13.8 0.7 0.039 13.8 0.7 1.8 2 0 0 2 2 1 0 emp24/gp25L/p24 family/GOLD Tropomyosin PF00261.18 001161666.1_29622001_1 - 0.04 13.1 5.9 0.037 13.3 1.5 1.7 1 1 1 2 2 2 0 Tropomyosin GAS PF13851.4 001161666.1_29622001_1 - 0.042 13.1 3.0 0.037 13.3 1.4 1.5 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Lipoprotein_7 PF01540.14 001161666.1_29622001_1 - 0.043 13.0 0.6 0.053 12.7 0.6 1.1 1 0 0 1 1 1 0 Adhesin lipoprotein APG6 PF04111.10 001161666.1_29622001_1 - 0.047 13.0 3.0 0.062 12.6 3.0 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Jnk-SapK_ap_N PF09744.7 001161666.1_29622001_1 - 0.06 13.4 3.1 0.08 13.0 3.1 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 HAUS-augmin3 PF14932.4 001161666.1_29622001_1 - 0.062 12.7 2.5 0.071 12.5 2.5 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Spc24 PF08286.9 001161666.1_29622001_1 - 0.062 13.4 4.6 0.053 13.6 2.0 1.9 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 FlaC_arch PF05377.9 001161666.1_29622001_1 - 0.066 13.5 1.0 0.17 12.2 0.5 1.8 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) FliJ PF02050.14 001161666.1_29622001_1 - 0.067 13.3 3.6 0.16 12.0 3.6 1.5 1 1 0 1 1 1 0 Flagellar FliJ protein TPR_MLP1_2 PF07926.10 001161666.1_29622001_1 - 0.079 12.9 5.1 0.29 11.1 4.5 1.9 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein PRKG1_interact PF15898.3 001161666.1_29622001_1 - 0.085 13.6 3.4 0.13 13.1 3.4 1.2 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DUF972 PF06156.11 001161666.1_29622001_1 - 0.088 13.3 1.1 0.14 12.7 0.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF972) GrpE PF01025.17 001161666.1_29622001_1 - 0.1 12.1 2.4 0.1 12.1 1.3 1.5 1 1 0 1 1 1 0 GrpE DUF3450 PF11932.6 001161666.1_29622001_1 - 0.11 11.7 4.2 0.15 11.2 4.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) CENP-H PF05837.10 001161666.1_29622001_1 - 0.11 12.8 6.2 0.32 11.3 5.2 1.9 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Macoilin PF09726.7 001161666.1_29622001_1 - 0.11 10.9 1.9 0.13 10.7 1.9 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF4200 PF13863.4 001161666.1_29622001_1 - 0.11 12.7 2.7 0.17 12.1 2.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) CCDC-167 PF15188.4 001161666.1_29622001_1 - 0.11 12.7 1.9 0.23 11.7 1.9 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 Golgin_A5 PF09787.7 001161666.1_29622001_1 - 0.14 11.5 4.0 0.17 11.2 4.0 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 IncA PF04156.12 001161666.1_29622001_1 - 0.14 11.8 16.6 0.083 12.5 14.1 1.9 1 1 0 1 1 1 0 IncA protein T2SSM PF04612.10 001161666.1_29622001_1 - 0.16 11.9 2.8 0.31 10.9 0.3 2.0 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein M V_ATPase_I PF01496.17 001161666.1_29622001_1 - 0.32 8.7 0.8 0.37 8.5 0.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2205 PF10224.7 001161666.1_29622001_1 - 0.33 10.8 3.2 0.33 10.8 1.4 1.9 1 1 1 2 2 2 0 Predicted coiled-coil protein (DUF2205) ZapB PF06005.10 001161666.1_29622001_1 - 0.35 11.2 6.3 0.22 11.8 1.9 2.3 1 1 1 2 2 2 0 Cell division protein ZapB KELK PF15796.3 001161666.1_29622001_1 - 0.38 11.1 3.6 0.35 11.3 1.6 1.8 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF515 PF04415.10 001161666.1_29622001_1 - 0.4 8.9 1.8 0.28 9.4 0.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF515) ABC_tran_CTD PF16326.3 001161666.1_29622001_1 - 0.43 10.7 4.8 6.4 7.0 4.5 2.7 1 1 0 1 1 1 0 ABC transporter C-terminal domain DivIC PF04977.13 001161666.1_29622001_1 - 3.4 7.4 8.0 1.1 9.0 0.7 2.9 1 1 2 3 3 3 0 Septum formation initiator Rib_hydrolayse PF02267.15 001243883.1_49826001_1 - 7.9e-84 280.7 2.3 1e-83 280.4 2.3 1.1 1 0 0 1 1 1 1 ADP-ribosyl cyclase 40S_SA_C PF16122.3 001195480.1_29623001_3 - 2.7e-28 99.0 21.2 4.5e-28 98.3 21.2 1.4 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus Ribosomal_S2 PF00318.18 001195480.1_29623001_3 - 1.9e-25 89.3 0.0 1.6e-12 47.0 0.0 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 Gp_dh_C PF02800.18 001195426.1_29623001_1 - 1.7e-69 232.3 0.0 2.3e-69 231.8 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.22 001195426.1_29623001_1 - 3.8e-39 133.0 0.1 8.3e-39 131.9 0.1 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.18 001195426.1_29623001_1 - 0.036 14.1 0.1 0.18 11.8 0.1 2.1 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Arf PF00025.19 001172161.1_29623001_3 - 1.6e-66 222.9 0.0 2.1e-66 222.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.20 001172161.1_29623001_3 - 8.2e-17 61.1 0.0 1.1e-16 60.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001172161.1_29623001_3 - 8.8e-17 61.3 0.1 1.5e-16 60.6 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 001172161.1_29623001_3 - 1.9e-11 43.6 0.0 3.4e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 001172161.1_29623001_3 - 3.7e-07 30.1 0.1 5.1e-07 29.6 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.18 001172161.1_29623001_3 - 8e-07 28.4 0.3 1.5e-05 24.2 0.1 2.2 1 1 1 2 2 2 1 G-protein alpha subunit Gtr1_RagA PF04670.10 001172161.1_29623001_3 - 0.00059 19.1 0.1 0.0012 18.1 0.1 1.5 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001172161.1_29623001_3 - 0.00091 18.7 0.1 0.0019 17.6 0.0 1.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.15 001172161.1_29623001_3 - 0.077 12.6 0.0 0.16 11.5 0.0 1.5 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein 6PF2K PF01591.16 001172161.1_29623001_3 - 0.077 12.1 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_28 PF13521.4 001172161.1_29623001_3 - 0.16 12.1 0.1 0.74 9.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain DUF1754 PF08555.8 001253785.1_08023001_1 - 1.2e-07 32.3 20.9 1.6e-05 25.5 20.9 2.4 1 1 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) Ras PF00071.20 001244437.1_49824001_1 - 2.2e-57 193.1 0.0 3e-57 192.6 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001244437.1_49824001_1 - 1.7e-22 79.8 0.0 2.5e-22 79.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001244437.1_49824001_1 - 7.7e-09 35.1 0.0 1.3e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001244437.1_49824001_1 - 0.004 16.6 0.0 0.0065 15.9 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain CDI PF02234.17 001270723.1_08025001_1 - 1.4e-18 66.7 0.1 2.1e-18 66.1 0.1 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor IL4Ra_N PF09238.8 001257232.1_08026001_1 - 2.9e-37 126.8 0.2 6.4e-37 125.6 0.2 1.6 1 0 0 1 1 1 1 Interleukin-4 receptor alpha chain, N-terminal fn3 PF00041.19 001257232.1_08026001_1 - 0.011 15.9 3.3 0.024 14.8 3.3 1.6 1 0 0 1 1 1 0 Fibronectin type III domain LRRC37AB_C PF14914.4 001257232.1_08026001_1 - 0.19 11.5 0.0 0.3 10.8 0.0 1.2 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain 7tm_1 PF00001.19 001195839.1_37923001_1 - 3e-45 154.4 13.5 3.8e-45 154.1 13.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001195839.1_37923001_1 - 8.8e-07 28.8 3.4 8.8e-07 28.8 3.4 2.1 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001195839.1_37923001_1 - 9.6e-07 28.3 5.7 1.6e-06 27.5 5.7 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF1294 PF06961.11 001195839.1_37923001_1 - 0.14 12.3 2.8 1.1 9.4 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1294) Comm PF15957.3 001195839.1_37923001_1 - 0.41 10.9 2.8 8.1 6.7 0.0 2.5 2 1 0 2 2 2 0 Commissureless TFIIE-A_C PF11521.6 001195445.1_29623001_1 - 0.04 14.1 0.1 0.064 13.5 0.1 1.2 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha Cyclin_N PF00134.21 001195445.1_29623001_2 - 1.3e-25 89.5 0.3 3e-25 88.3 0.3 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 001195445.1_29623001_2 - 0.0068 16.4 6.4 0.013 15.4 2.4 2.3 2 0 0 2 2 2 1 Cyclin, C-terminal domain S10_plectin PF03501.13 001193579.1_29622001_1 - 3.5e-50 167.9 0.2 4.3e-50 167.6 0.2 1.1 1 0 0 1 1 1 1 Plectin/S10 domain zf-H2C2_2 PF13465.4 001270935.1_08024001_1 - 6.2e-82 266.5 83.2 2.1e-08 34.1 1.2 13.5 14 0 0 14 14 12 12 Zinc-finger double domain zf-C2H2 PF00096.24 001270935.1_08024001_1 - 1.1e-62 204.9 91.3 4.2e-06 26.8 4.3 14.0 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001270935.1_08024001_1 - 4.3e-29 98.5 101.3 0.003 18.1 2.7 14.5 15 0 0 15 15 14 11 C2H2-type zinc finger KRAB PF01352.25 001270935.1_08024001_1 - 5.9e-25 86.5 0.7 1.2e-24 85.5 0.7 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 001270935.1_08024001_1 - 1.7e-11 43.7 69.7 0.014 15.2 0.3 13.1 12 1 0 12 12 12 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001270935.1_08024001_1 - 8.3e-09 35.3 51.1 0.01 15.8 1.0 8.5 3 3 6 9 9 9 9 Zinc ribbon domain zf-C2H2_jaz PF12171.6 001270935.1_08024001_1 - 9.5e-08 32.0 60.9 0.031 14.4 0.8 12.3 12 0 0 12 12 12 6 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 001270935.1_08024001_1 - 0.057 13.3 46.9 2.3 8.2 0.1 12.0 12 0 0 12 12 12 0 XPA protein N-terminal zf-trcl PF13451.4 001270935.1_08024001_1 - 0.47 10.3 50.1 4.9 7.0 0.1 10.9 12 0 0 12 12 12 0 Probable zinc-ribbon domain zinc_ribbon_9 PF14369.4 001270935.1_08024001_1 - 0.71 10.1 37.3 1.1 9.5 0.0 9.1 10 2 2 12 12 12 0 zinc-ribbon GAGA PF09237.9 001270935.1_08024001_1 - 0.81 9.4 9.8 12 5.6 1.1 4.6 3 1 1 4 4 4 0 GAGA factor zinc_ribbon_15 PF17032.3 001270935.1_08024001_1 - 1.5 9.5 58.1 2.1 9.0 2.1 7.5 2 1 9 11 11 10 0 zinc-ribbon family DUF3268 PF11672.6 001270935.1_08024001_1 - 5.1 7.3 40.1 0.92 9.7 1.7 7.5 2 1 7 10 10 10 0 zinc-finger-containing domain eIF_4EBP PF05456.9 001205007.1_08022001_3 - 1.2e-37 128.2 1.5 1.6e-37 127.8 1.5 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Protamine_P1 PF00260.18 001163050.1_39521001_1 - 2.6e-12 46.5 63.6 3.2e-12 46.2 63.6 1.1 1 0 0 1 1 1 1 Protamine P1 Arf PF00025.19 001145220.1_49822001_3 - 2.9e-78 261.2 0.1 3.7e-78 260.8 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001145220.1_49822001_3 - 7.8e-14 51.4 0.0 1e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.11 001145220.1_49822001_3 - 3e-13 49.9 0.0 4.3e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001145220.1_49822001_3 - 9e-12 44.7 0.0 1.1e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.10 001145220.1_49822001_3 - 4e-11 42.6 0.0 5.1e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.18 001145220.1_49822001_3 - 8.8e-11 41.4 1.8 4e-08 32.7 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.21 001145220.1_49822001_3 - 6.3e-05 22.9 0.0 0.0001 22.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001145220.1_49822001_3 - 0.016 15.0 0.1 0.2 11.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF258 6PF2K PF01591.16 001145220.1_49822001_3 - 0.072 12.3 0.5 0.23 10.6 0.1 1.8 2 0 0 2 2 2 0 6-phosphofructo-2-kinase cobW PF02492.17 001145220.1_49822001_3 - 0.15 11.5 0.3 0.98 8.8 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain EMP24_GP25L PF01105.22 001204342.1_08028001_3 - 6.1e-49 166.3 0.3 8.1e-49 165.9 0.3 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Fucokinase PF07959.10 001204801.2_08029001_2 - 2.9e-144 480.9 0.1 3.7e-144 480.5 0.1 1.1 1 0 0 1 1 1 1 L-fucokinase Hexapep PF00132.22 001204801.2_08029001_2 - 0.11 12.1 1.8 0.18 11.5 0.2 2.2 2 0 0 2 2 2 0 Bacterial transferase hexapeptide (six repeats) V-set PF07686.15 054063.4_32924001_2 - 8.3e-41 138.4 1.2 7.4e-11 42.0 0.0 4.9 4 1 0 4 4 4 4 Immunoglobulin V-set domain Ig_3 PF13927.4 054063.4_32924001_2 - 5.2e-23 81.3 0.4 7.4e-09 36.0 0.2 4.5 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.14 054063.4_32924001_2 - 3.8e-21 74.8 0.0 1.8e-09 37.4 0.0 4.3 4 0 0 4 4 4 3 Immunoglobulin I-set domain ig PF00047.23 054063.4_32924001_2 - 3.9e-14 52.4 6.5 2.5e-08 33.9 0.4 4.4 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.4 054063.4_32924001_2 - 6.8e-14 51.9 1.6 6e-07 29.6 0.5 4.9 4 1 0 4 4 4 3 Immunoglobulin domain Receptor_2B4 PF11465.6 054063.4_32924001_2 - 5.7e-06 26.4 0.1 0.42 10.7 0.0 4.1 4 0 0 4 4 4 1 Natural killer cell receptor 2B4 Izumo-Ig PF16706.3 054063.4_32924001_2 - 0.17 11.8 1.5 1.6 8.7 0.0 3.2 5 0 0 5 5 5 0 Izumo-like Immunoglobulin domain Herpes_gE PF02480.14 054063.4_32924001_2 - 0.5 8.9 2.8 1.1 7.7 0.3 2.6 3 1 1 4 4 4 0 Alphaherpesvirus glycoprotein E Fungal_lectin PF07938.10 054063.4_32924001_2 - 0.83 8.8 2.7 1.4 8.1 0.1 2.4 3 1 1 4 4 4 0 Fungal fucose-specific lectin Trypsin PF00089.24 182983.2_26225001_1 - 3.1e-67 226.5 0.1 4.5e-67 226.0 0.1 1.2 1 0 0 1 1 1 1 Trypsin Hepsin-SRCR PF09272.8 182983.2_26225001_1 - 2.3e-64 214.4 1.1 4.4e-64 213.5 1.1 1.5 1 0 0 1 1 1 1 Hepsin, SRCR SRCR_2 PF15494.4 182983.2_26225001_1 - 8.9e-08 32.4 0.1 1.5e-07 31.7 0.1 1.4 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain DUF1986 PF09342.9 182983.2_26225001_1 - 0.00037 20.7 0.1 0.0039 17.4 0.1 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 182983.2_26225001_1 - 0.0014 19.4 0.1 0.0033 18.2 0.1 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain Sep15_SelM PF08806.9 001199931.1_08022001_2 - 2.4e-21 75.6 0.0 3.3e-21 75.1 0.0 1.2 1 0 0 1 1 1 1 Sep15/SelM redox domain Troponin PF00992.18 001243071.1_08022001_1 - 1e-46 158.4 6.7 1.4e-46 158.0 6.7 1.2 1 0 0 1 1 1 1 Troponin BAF PF02961.12 001253760.1_08023001_3 - 1.5e-43 147.0 0.1 2.1e-43 146.5 0.1 1.2 1 0 0 1 1 1 1 Barrier to autointegration factor IMS_HHH PF11798.6 001253760.1_08023001_3 - 0.034 14.3 1.3 0.04 14.1 0.1 1.8 2 0 0 2 2 2 0 IMS family HHH motif UBA_4 PF14555.4 001253765.1_08023001_2 - 1.6e-09 37.3 0.1 3e-09 36.4 0.1 1.4 1 0 0 1 1 1 1 UBA-like domain Exo_endo_phos PF03372.21 001253765.1_08023001_2 - 1.4e-07 31.6 0.0 2e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Rieske PF00355.24 001205137.1_08024001_1 - 0.77 9.6 5.7 1.4 8.8 5.7 1.4 1 0 0 1 1 1 0 Rieske [2Fe-2S] domain DEAD PF00270.27 001205137.1_08024001_2 - 4.1e-44 150.3 0.3 6.4e-44 149.7 0.3 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001205137.1_08024001_2 - 5.1e-31 107.2 0.7 2.2e-30 105.1 0.1 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.13 001205137.1_08024001_2 - 8.8e-07 28.9 0.0 1.4e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.4 001205137.1_08024001_2 - 0.00095 19.4 0.4 0.0025 18.0 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.4 001205137.1_08024001_2 - 0.0046 16.6 0.0 0.0076 15.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.12 001205137.1_08024001_2 - 0.083 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Helicase Flavi_DEAD PF07652.12 001205137.1_08024001_2 - 0.1 12.4 0.0 0.57 10.0 0.0 2.0 2 0 0 2 2 2 0 Flavivirus DEAD domain RCC1 PF00415.16 001205208.1_08023001_1 - 6.3e-86 282.7 17.8 2e-14 53.8 0.0 7.4 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 001205208.1_08023001_1 - 1.4e-32 110.7 30.3 6.9e-09 35.2 0.3 7.8 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat Peptidase_C25_C PF03785.12 001205208.1_08023001_1 - 0.00071 19.2 0.0 0.67 9.7 0.0 3.4 4 0 0 4 4 4 2 Peptidase family C25, C terminal ig-like domain SUKH-3 PF14433.4 001205208.1_08023001_1 - 0.0042 17.4 1.8 47 4.3 0.0 5.0 5 0 0 5 5 5 0 SUKH-3 immunity protein p450 PF00067.20 001204443.1_08024001_1 - 5.7e-130 434.0 0.1 6.5e-130 433.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Coa1 PF08695.8 001204443.1_08024001_1 - 0.051 13.2 0.0 0.098 12.3 0.0 1.4 1 0 0 1 1 1 0 Cytochrome oxidase complex assembly protein 1 Lyase_1 PF00206.18 001243588.1_49824001_2 - 2.7e-123 411.2 0.1 3.6e-123 410.8 0.1 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.7 001243588.1_49824001_2 - 1.9e-26 92.1 0.4 5.7e-26 90.6 0.1 2.0 2 0 0 2 2 2 1 Fumarase C C-terminus DUF1899 PF08953.9 146744.2_32922001_1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1899) 7tm_4 PF13853.4 146744.2_32922001_2 - 1.1e-50 172.8 13.4 1.5e-50 172.4 13.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 146744.2_32922001_2 - 1.3e-23 83.4 18.4 3.4e-23 82.1 18.4 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 146744.2_32922001_2 - 0.068 12.4 15.0 0.057 12.7 13.2 1.6 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx DUF1634 PF07843.9 146744.2_32922001_2 - 3 7.8 8.8 0.18 11.8 1.4 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1634) CENP-S PF15630.4 001204928.1_08023001_3 - 4.6e-32 110.1 0.6 7.8e-32 109.4 0.6 1.4 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.4 001204928.1_08023001_3 - 2.5e-09 37.1 0.4 4.4e-09 36.3 0.4 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Bromo_TP PF07524.11 001204928.1_08023001_3 - 0.12 12.3 0.1 0.3 11.0 0.1 1.6 1 0 0 1 1 1 0 Bromodomain associated Histone PF00125.22 001204928.1_08023001_3 - 5.2 7.3 14.4 1.2 9.4 7.7 2.7 1 1 1 2 2 2 0 Core histone H2A/H2B/H3/H4 zf-A20 PF01754.14 001246634.1_39724001_2 - 8.5e-12 44.7 8.8 8.5e-12 44.7 8.8 2.0 2 0 0 2 2 2 1 A20-like zinc finger zf-AN1 PF01428.14 001246634.1_39724001_2 - 6.4e-09 35.7 7.7 6.4e-09 35.7 7.7 2.1 2 0 0 2 2 2 1 AN1-like Zinc finger PGK PF00162.17 001195658.1_29624001_3 - 1.4e-150 501.3 0.4 1.7e-150 501.1 0.4 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase DUF3172 PF11371.6 001195658.1_29624001_3 - 0.097 12.3 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3172) KH_1 PF00013.27 001172108.1_29622001_3 - 0.00036 20.1 0.7 0.00096 18.8 0.7 1.7 1 0 0 1 1 1 1 KH domain RPE65 PF03055.13 001159278.1_39524001_1 - 2.3e-115 386.0 0.0 2.6e-115 385.8 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Collagen PF01391.16 001243297.1_49829001_3 - 1.1e-159 518.2 767.6 4.4e-11 42.2 31.3 21.1 2 1 12 15 15 15 12 Collagen triple helix repeat (20 copies) COLFI PF01410.16 001243297.1_49829001_3 - 3.2e-107 357.0 0.0 4.1e-107 356.7 0.0 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain VWC PF00093.16 001243297.1_49829001_3 - 1.2e-11 44.6 13.4 1.2e-11 44.6 13.4 1.7 2 0 0 2 2 2 1 von Willebrand factor type C domain RRM_1 PF00076.20 001205240.1_08029001_1 - 2.8e-08 33.3 0.0 0.0025 17.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2_jaz PF12171.6 001205240.1_08029001_1 - 0.031 14.5 8.8 1.8 8.9 1.1 3.0 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding ASF1_hist_chap PF04729.11 001166188.1_39524001_2 - 1.9e-71 238.9 0.1 2.7e-71 238.4 0.1 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone Pkinase_Tyr PF07714.15 001270588.1_08028001_2 - 1.8e-108 361.6 0.0 3e-108 360.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001270588.1_08028001_2 - 3.4e-44 151.0 0.0 5.3e-29 101.2 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.4 001270588.1_08028001_2 - 5.2e-23 81.3 8.1 3.2e-07 30.7 0.0 5.4 5 0 0 5 5 5 4 Immunoglobulin domain I-set PF07679.14 001270588.1_08028001_2 - 1.7e-21 75.9 8.4 1.5e-08 34.4 0.1 5.2 5 0 0 5 5 5 3 Immunoglobulin I-set domain ig PF00047.23 001270588.1_08028001_2 - 1.7e-16 60.0 7.9 2.6e-05 24.2 0.1 5.5 5 0 0 5 5 5 3 Immunoglobulin domain Ig_2 PF13895.4 001270588.1_08028001_2 - 6.4e-13 48.7 4.2 8.2e-05 22.8 0.0 4.6 4 0 0 4 4 4 3 Immunoglobulin domain V-set PF07686.15 001270588.1_08028001_2 - 4.1e-05 23.6 3.1 0.5 10.4 0.1 4.6 3 2 0 3 3 3 2 Immunoglobulin V-set domain Herpes_gE PF02480.14 001270588.1_08028001_2 - 0.00016 20.4 0.9 0.011 14.4 0.5 3.0 2 1 0 2 2 2 1 Alphaherpesvirus glycoprotein E C2-set_2 PF08205.10 001270588.1_08028001_2 - 0.046 13.7 4.4 0.19 11.7 0.0 3.6 4 0 0 4 4 4 0 CD80-like C2-set immunoglobulin domain LAT PF15234.4 001270588.1_08028001_2 - 0.1 12.2 0.5 0.24 11.0 0.5 1.5 1 0 0 1 1 1 0 Linker for activation of T-cells TNF PF00229.16 001205140.1_08025001_3 - 1.4e-11 44.3 0.0 2.5e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family DUF1049 PF06305.9 001205140.1_08025001_3 - 0.0098 15.6 0.7 0.023 14.4 0.7 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1049) Somatostatin PF03002.13 001204927.1_08023001_3 - 2.3e-09 36.9 7.5 4.3e-09 36.0 7.5 1.5 1 0 0 1 1 1 1 Somatostatin/Cortistatin family NOG1 PF06858.12 001253779.1_08026001_3 - 1.9e-26 91.4 0.0 4.5e-26 90.3 0.0 1.7 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) NOGCT PF08155.9 001253779.1_08026001_3 - 2.2e-21 75.4 5.3 4.4e-21 74.5 3.0 2.6 2 0 0 2 2 2 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.21 001253779.1_08026001_3 - 1.2e-09 38.1 0.0 2.8e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 001253779.1_08026001_3 - 2.6e-07 30.1 0.0 4.8e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.25 001253779.1_08026001_3 - 0.024 14.0 0.0 0.044 13.2 0.0 1.6 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Ras PF00071.20 001253779.1_08026001_3 - 0.064 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Ras family Dynamin_N PF00350.21 001253779.1_08026001_3 - 0.24 11.3 0.0 0.24 11.3 0.0 2.0 2 0 0 2 2 2 0 Dynamin family DUF1690 PF07956.9 001253779.1_08026001_3 - 1.9 8.8 8.3 0.21 11.9 3.2 2.0 2 0 0 2 2 2 0 Protein of Unknown function (DUF1690) 7tm_1 PF00001.19 001270913.1_08023001_1 - 2.4e-22 79.3 2.0 2.4e-22 79.3 2.0 1.5 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) DUF1438 PF07270.9 153523.3_32922001_1 - 5.6e-92 305.6 2.0 7.1e-92 305.2 2.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1438) DnaJ PF00226.29 001204974.1_08025001_2 - 5.5e-19 67.9 0.0 1.3e-18 66.7 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain Sod_Cu PF00080.18 001185042.1_08022001_1 - 8.2e-41 139.3 0.3 1.3e-40 138.7 0.3 1.2 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) HMA PF00403.24 001185042.1_08022001_1 - 1.4e-10 41.4 0.1 2.1e-10 40.7 0.1 1.3 1 0 0 1 1 1 1 Heavy-metal-associated domain p450 PF00067.20 001177788.1_29624001_3 - 1.1e-157 525.4 0.2 1.2e-157 525.3 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 C2-set_2 PF08205.10 001257221.1_08022001_2 - 5.1e-21 74.4 0.0 1.1e-20 73.4 0.0 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 001257221.1_08022001_2 - 9.3e-10 38.9 0.2 0.00093 19.6 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 001257221.1_08022001_2 - 4.5e-09 36.3 0.1 8.5e-09 35.4 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 001257221.1_08022001_2 - 1.6e-07 31.3 0.5 4.1e-05 23.5 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001257221.1_08022001_2 - 3.9e-07 29.9 0.1 0.0041 17.0 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain C1-set PF07654.13 001257221.1_08022001_2 - 3.9e-06 27.1 0.1 1.8e-05 25.0 0.0 2.0 2 1 0 2 2 2 1 Immunoglobulin C1-set domain Ig_2 PF13895.4 001257221.1_08022001_2 - 1.2e-05 25.5 0.0 0.25 11.6 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Cadherin_C_2 PF16492.3 001257221.1_08022001_2 - 0.1 13.3 0.1 1.8 9.3 0.0 2.3 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal RnaseA PF00074.18 001270922.1_08023001_2 - 6.9e-32 110.4 0.4 1e-31 109.9 0.4 1.2 1 0 0 1 1 1 1 Pancreatic ribonuclease G-gamma PF00631.20 001204975.1_08023001_2 - 5.3e-15 55.0 0.0 9e-15 54.3 0.0 1.3 1 0 0 1 1 1 1 GGL domain MHC_II_alpha PF00993.18 001270911.1_08023001_1 - 1.3e-34 117.6 0.2 1.9e-34 117.1 0.2 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001270911.1_08023001_1 - 5.4e-29 99.2 0.6 9.1e-29 98.5 0.1 1.6 2 0 0 2 2 2 1 C1-set C-terminal domain C1-set PF07654.13 001270911.1_08023001_1 - 2.8e-21 75.7 0.0 4.8e-21 74.9 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Marek_A PF02124.13 001270911.1_08023001_1 - 0.00066 19.4 0.0 0.0015 18.3 0.0 1.5 1 0 0 1 1 1 1 Marek's disease glycoprotein A Ig_3 PF13927.4 001270911.1_08023001_1 - 0.00099 19.5 0.0 0.002 18.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Pkinase_Tyr PF07714.15 001204802.1_08027001_3 - 6.4e-58 195.9 0.0 2.4e-57 194.1 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Ank_2 PF12796.5 001204802.1_08027001_3 - 2.3e-55 185.0 8.5 3.1e-16 59.6 0.4 6.3 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001204802.1_08027001_3 - 1.3e-48 162.6 29.6 2.1e-11 44.0 0.3 7.9 3 3 6 9 9 9 9 Ankyrin repeats (many copies) Ank PF00023.28 001204802.1_08027001_3 - 1e-47 158.4 28.7 8.4e-07 29.1 0.0 11.1 12 0 0 12 12 11 8 Ankyrin repeat Pkinase PF00069.23 001204802.1_08027001_3 - 6.7e-46 156.6 0.0 1.5e-45 155.5 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Ank_3 PF13606.4 001204802.1_08027001_3 - 2.5e-41 134.8 13.9 0.00046 20.3 0.0 10.9 10 0 0 10 10 10 8 Ankyrin repeat Ank_5 PF13857.4 001204802.1_08027001_3 - 3.3e-37 125.8 10.0 7.6e-09 35.6 0.1 8.3 2 1 6 9 9 8 7 Ankyrin repeats (many copies) APH PF01636.21 001204802.1_08027001_3 - 0.054 13.3 0.0 0.087 12.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.12 001204802.1_08027001_3 - 0.065 12.5 0.1 0.11 11.7 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 001204802.1_08027001_3 - 0.078 12.4 1.5 0.16 11.4 0.1 2.0 2 0 0 2 2 2 0 RIO1 family Kinase-like PF14531.4 001204802.1_08027001_3 - 0.097 11.8 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Brix PF04427.16 001204432.1_08024001_2 - 6.7e-44 150.2 0.1 9.5e-44 149.7 0.1 1.2 1 0 0 1 1 1 1 Brix domain Dynein_light PF01221.16 001195114.2_49822001_3 - 3.3e-42 142.5 1.9 4.4e-42 142.1 1.9 1.2 1 0 0 1 1 1 1 Dynein light chain type 1 NDK PF00334.17 001204876.1_08022001_1 - 1.3e-54 183.7 0.0 1.6e-54 183.4 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase zf-H2C2_2 PF13465.4 001270921.1_08027001_3 - 1.8e-149 480.0 134.2 2.5e-08 33.9 0.2 23.7 23 0 0 23 23 23 21 Zinc-finger double domain zf-C2H2 PF00096.24 001270921.1_08027001_3 - 1.9e-126 405.8 143.1 4e-07 30.0 0.9 23.8 23 0 0 23 23 23 22 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001270921.1_08027001_3 - 1.6e-66 215.0 138.3 0.002 18.7 0.6 23.5 23 0 0 23 23 23 20 C2H2-type zinc finger KRAB PF01352.25 001270921.1_08027001_3 - 3.6e-24 84.0 0.0 6.8e-24 83.2 0.0 1.5 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 001270921.1_08027001_3 - 7.7e-24 83.4 87.2 0.00065 19.6 1.2 14.4 7 5 9 16 16 16 11 Zinc ribbon domain zf-C2H2_6 PF13912.4 001270921.1_08027001_3 - 7.2e-21 73.5 114.5 0.057 13.3 0.4 21.5 21 0 0 21 21 21 13 C2H2-type zinc finger DZR PF12773.5 001270921.1_08027001_3 - 7.1e-13 48.2 78.9 0.052 13.4 3.4 11.3 2 2 4 6 6 6 3 Double zinc ribbon zf-C2H2_jaz PF12171.6 001270921.1_08027001_3 - 9.1e-09 35.3 91.5 0.04 14.1 0.1 18.7 20 0 0 20 20 20 7 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 001270921.1_08027001_3 - 1.1e-08 35.3 71.9 0.24 11.6 1.0 12.2 7 2 6 14 14 14 11 zinc-finger-containing domain C1_4 PF07975.10 001270921.1_08027001_3 - 2e-08 34.3 90.5 0.22 11.7 7.6 13.7 6 4 8 15 15 15 8 TFIIH C1-like domain zinc_ribbon_15 PF17032.3 001270921.1_08027001_3 - 2.9e-07 31.0 87.4 0.35 11.5 1.2 11.7 2 2 9 13 13 12 7 zinc-ribbon family ADK_lid PF05191.12 001270921.1_08027001_3 - 6.7e-06 25.9 61.7 0.01 15.7 0.2 12.6 5 3 6 12 12 12 2 Adenylate kinase, active site lid XPA_N PF01286.16 001270921.1_08027001_3 - 1.1e-05 25.2 76.4 11 6.0 0.0 19.7 21 0 0 21 21 21 0 XPA protein N-terminal zf-trcl PF13451.4 001270921.1_08027001_3 - 0.00072 19.3 84.7 6.4 6.6 0.1 19.6 19 2 1 20 20 20 1 Probable zinc-ribbon domain zf-LYAR PF08790.9 001270921.1_08027001_3 - 0.014 15.1 91.2 2.8 7.8 0.1 19.2 20 0 0 20 20 20 0 LYAR-type C2HC zinc finger FYVE PF01363.19 001270921.1_08027001_3 - 0.42 10.6 92.3 0.013 15.5 5.3 10.1 1 1 6 7 7 5 0 FYVE zinc finger MBD PF01429.17 001270921.1_08027001_3 - 0.87 9.2 5.4 4.4 6.9 0.2 4.5 4 1 0 4 4 3 0 Methyl-CpG binding domain zinc_ribbon_9 PF14369.4 001270921.1_08027001_3 - 1.1 9.5 56.0 26 5.0 0.0 17.1 20 1 0 20 20 20 0 zinc-ribbon zf-C2H2_11 PF16622.3 001270921.1_08027001_3 - 1.6 8.5 108.0 0.81 9.4 1.0 19.7 21 0 0 21 21 21 0 zinc-finger C2H2-type CpXC PF14353.4 001270921.1_08027001_3 - 1.9 8.4 73.3 4.4 7.2 0.5 16.7 1 1 12 16 16 16 0 CpXC protein Zn_ribbon_recom PF13408.4 001270921.1_08027001_3 - 8.7 6.8 97.5 9.3 6.7 1.1 15.6 6 3 10 17 17 17 0 Recombinase zinc beta ribbon domain BDHCT_assoc PF16204.3 001270921.1_08027001_3 - 9.6 5.7 14.4 1.1 8.7 0.3 4.4 3 1 1 5 5 5 0 BDHCT-box associated domain on Bloom syndrome protein p450 PF00067.20 001204442.1_08024001_1 - 2.7e-131 438.4 0.0 3e-131 438.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Coa1 PF08695.8 001204442.1_08024001_1 - 0.074 12.7 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Cytochrome oxidase complex assembly protein 1 COX4 PF02936.12 001193548.1_29622001_3 - 7.5e-58 194.3 2.8 9e-58 194.1 2.8 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV COX2_TM PF02790.13 001190247.1_49822001_1 - 0.0074 16.3 0.4 0.015 15.3 0.4 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, transmembrane domain FAM176 PF14851.4 001190247.1_49822001_1 - 0.0091 15.6 0.2 0.96 9.0 0.2 2.3 2 0 0 2 2 2 2 FAM176 family DUF912 PF06024.10 001190247.1_49822001_1 - 0.028 14.6 1.3 0.15 12.2 0.3 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF2701 PF10857.6 001190247.1_49822001_1 - 0.069 13.0 1.8 0.15 12.0 1.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2701) OAD_gamma PF04277.11 001190247.1_49822001_1 - 1.9 9.0 3.9 2.1 8.9 0.0 2.3 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Acetyltransf_2 PF00797.15 001171149.1_37922001_1 - 1.5e-90 303.1 0.2 1.7e-90 302.9 0.2 1.0 1 0 0 1 1 1 1 N-acetyltransferase Leptin PF02024.13 001163069.1_37922001_1 - 3.9e-69 230.9 0.1 4.4e-69 230.7 0.1 1.0 1 0 0 1 1 1 1 Leptin Asparaginase_2 PF01112.16 001199093.1_29623001_3 - 4.8e-86 288.4 0.1 6.3e-86 288.0 0.1 1.0 1 0 0 1 1 1 1 Asparaginase PIP5K PF01504.16 001195781.1_49827001_3 - 3.1e-74 249.5 0.0 4.3e-74 249.1 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Rpr2 PF04032.14 001244694.1_49822001_2 - 2.6e-25 88.5 7.2 3.4e-25 88.1 7.2 1.2 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain FAM181 PF15238.4 001270909.1_08023001_1 - 4.6e-115 384.2 2.1 6.9e-115 383.7 2.1 1.3 1 0 0 1 1 1 1 FAM181 Ectoine_synth PF06339.10 001246475.1_39726001_1 - 0.093 12.8 0.1 0.54 10.3 0.0 2.2 1 1 0 2 2 2 0 Ectoine synthase zf-H2C2_2 PF13465.4 001246475.1_39726001_3 - 1.2e-81 265.6 110.3 6.7e-10 38.8 3.3 14.8 14 1 0 14 14 14 12 Zinc-finger double domain zf-C2H2 PF00096.24 001246475.1_39726001_3 - 1.6e-51 169.8 122.9 4.9e-06 26.6 1.4 14.4 15 0 0 15 15 14 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001246475.1_39726001_3 - 3.4e-30 102.0 111.6 0.00052 20.5 1.2 13.9 13 0 0 13 13 13 11 C2H2-type zinc finger KRAB PF01352.25 001246475.1_39726001_3 - 4.5e-21 74.1 0.1 8e-21 73.3 0.1 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 001246475.1_39726001_3 - 1.1e-13 50.9 73.0 0.011 15.9 0.4 12.2 11 1 1 12 12 11 8 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001246475.1_39726001_3 - 2.5e-11 43.1 98.1 0.0038 17.0 0.7 12.6 12 0 0 12 12 12 7 C2H2-type zinc finger GAGA PF09237.9 001246475.1_39726001_3 - 1.5e-05 24.6 22.8 0.41 10.4 0.1 7.9 2 2 7 9 9 9 3 GAGA factor Zn-ribbon_8 PF09723.8 001246475.1_39726001_3 - 0.00045 20.2 54.8 0.014 15.3 0.2 9.0 6 1 2 9 9 9 5 Zinc ribbon domain Ta0938 PF11494.6 001246475.1_39726001_3 - 0.01 15.9 25.7 2.1 8.5 0.5 6.8 2 1 5 7 7 7 0 Ta0938 BHD_1 PF10403.7 001246475.1_39726001_3 - 0.027 14.1 4.1 11 5.8 0.0 4.8 4 2 0 4 4 4 0 Rad4 beta-hairpin domain 1 zf-CCHC_2 PF13696.4 001246475.1_39726001_3 - 1.2 8.8 72.4 0.74 9.6 1.0 12.1 12 0 0 12 12 12 0 Zinc knuckle BolA PF01722.16 001246475.1_39726001_3 - 1.5 9.0 27.9 3.7 7.8 0.3 6.2 4 1 2 6 6 5 0 BolA-like protein FYVE PF01363.19 001246475.1_39726001_3 - 1.6 8.8 72.1 2.4 8.2 5.2 8.2 1 1 5 6 6 6 0 FYVE zinc finger zinc_ribbon_15 PF17032.3 001246475.1_39726001_3 - 8.4 7.1 41.9 1.3 9.7 1.3 6.4 3 1 3 6 6 6 0 zinc-ribbon family TMEM189_B_dmain PF10520.7 001205088.1_08025001_3 - 4.3e-76 254.9 1.2 6.4e-76 254.3 1.2 1.3 1 0 0 1 1 1 1 B domain of TMEM189, localisation domain RRM_1 PF00076.20 001195808.1_29625001_2 - 8.2e-13 47.8 0.0 1.4e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001195808.1_29625001_2 - 0.015 15.3 0.0 0.03 14.3 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif Proteasome PF00227.24 001195714.1_29622001_1 - 3.3e-46 157.0 0.2 3.9e-46 156.8 0.2 1.0 1 0 0 1 1 1 1 Proteasome subunit LAT PF15234.4 001195714.1_29622001_3 - 0.13 11.9 0.0 0.17 11.5 0.0 1.1 1 0 0 1 1 1 0 Linker for activation of T-cells Clusterin PF01093.15 001195474.1_29624001_3 - 1.6e-157 524.9 11.5 1.9e-157 524.6 11.5 1.1 1 0 0 1 1 1 1 Clusterin CREPT PF16566.3 001195474.1_29624001_3 - 0.075 13.1 10.1 0.51 10.4 3.7 2.5 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour SOAR PF16533.3 001195474.1_29624001_3 - 0.076 12.8 2.4 0.99 9.3 0.9 2.6 2 0 0 2 2 2 0 STIM1 Orai1-activating region RE_AlwI PF09491.8 001195474.1_29624001_3 - 0.11 11.1 6.4 0.016 13.9 1.9 1.7 2 0 0 2 2 2 0 AlwI restriction endonuclease T3SSipB PF16535.3 001195474.1_29624001_3 - 0.28 11.5 4.2 0.16 12.3 0.5 2.2 2 0 0 2 2 2 0 Type III cell invasion protein SipB RPW8 PF05659.9 001195474.1_29624001_3 - 0.46 10.0 5.6 1.4 8.5 0.1 3.0 3 0 0 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 TBPIP PF07106.11 001195474.1_29624001_3 - 1.1 8.9 13.3 0.1 12.2 5.6 2.4 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) zf-C4pol PF14260.4 001195474.1_29624001_3 - 3.4 8.1 9.9 1 9.8 1.1 2.9 2 0 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta Voldacs PF03517.11 001171027.1_37924001_2 - 1.3e-31 109.5 0.3 1.8e-31 109.0 0.3 1.2 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling Lipocalin PF00061.21 001164509.1_49822001_3 - 4.1e-23 82.0 0.5 4.8e-23 81.8 0.5 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 001164509.1_49822001_3 - 2.7e-06 27.2 0.1 3.3e-06 26.9 0.1 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family W_rich_C PF07483.9 001164509.1_49822001_3 - 0.12 12.4 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Tryptophan-rich Synechocystis species C-terminal domain His_Phos_1 PF00300.20 001253767.1_08024001_3 - 3.3e-34 118.2 0.1 2e-26 92.8 0.1 2.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Alk_phosphatase PF00245.18 001185034.1_08026001_1 - 2.3e-177 590.0 0.2 2.8e-177 589.7 0.2 1.1 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.16 001185034.1_08026001_1 - 0.0062 15.8 0.0 0.011 15.0 0.0 1.5 1 1 0 1 1 1 1 Metalloenzyme superfamily UQ_con PF00179.24 001205089.1_08022001_3 - 1.2e-17 63.7 0.0 1.6e-17 63.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.20 001205089.1_08022001_3 - 0.091 12.9 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 RWD domain F5_F8_type_C PF00754.23 001172550.1_39529001_1 - 7.9e-54 181.0 0.1 1.6e-27 96.0 0.1 2.6 2 0 0 2 2 2 2 F5/8 type C domain Cu-oxidase_3 PF07732.13 001172550.1_39529001_1 - 1.5e-15 57.2 0.0 6.6e-05 22.8 0.0 4.0 3 0 0 3 3 3 3 Multicopper oxidase Cu-oxidase_2 PF07731.12 001172550.1_39529001_1 - 5.7e-12 45.4 16.9 5.6e-08 32.5 0.2 5.6 5 1 0 5 5 5 3 Multicopper oxidase Cu-oxidase PF00394.20 001172550.1_39529001_1 - 1.5e-08 34.7 0.0 0.00048 20.1 0.0 2.6 2 0 0 2 2 2 2 Multicopper oxidase Wx5_PLAF3D7 PF09688.8 001172550.1_39529001_1 - 0.091 12.6 0.1 0.31 10.9 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (Wx5_PLAF3D7) Ribosomal_S17_N PF16205.3 001195754.1_29622001_2 - 6.5e-37 125.6 0.8 6.5e-37 125.6 0.8 1.8 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.18 001195754.1_29622001_2 - 1.8e-29 101.5 1.7 3e-29 100.8 1.7 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 PRF PF06875.9 001195754.1_29622001_2 - 0.14 11.4 0.1 0.23 10.8 0.1 1.2 1 0 0 1 1 1 0 Plethodontid receptivity factor PRF Ribosomal_L23eN PF03939.11 001193565.1_29622001_1 - 4.5e-28 97.1 17.1 4.5e-28 97.1 17.1 2.1 2 0 0 2 2 2 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.18 001193565.1_29622001_1 - 4e-16 59.0 3.2 4e-16 59.0 3.2 2.6 2 2 0 2 2 2 1 Ribosomal protein L23 Ribosomal_L6 PF00347.21 001193565.1_29622001_1 - 0.054 14.1 1.2 0.083 13.4 0.1 1.8 2 0 0 2 2 2 0 Ribosomal protein L6 TIR_2 PF13676.4 001204343.1_08022001_1 - 2.2e-08 34.2 0.0 3.7e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 TIR domain TIR PF01582.18 001204343.1_08022001_1 - 0.00066 19.4 0.0 0.0018 17.9 0.0 1.7 2 0 0 2 2 2 1 TIR domain ApoC-I PF04691.10 001160281.2_37921001_2 - 4.8e-30 103.1 4.9 5.9e-30 102.9 4.9 1.1 1 0 0 1 1 1 1 Apolipoprotein C-I (ApoC-1) Apo-CIII PF05778.10 001160281.2_37921001_2 - 0.017 14.6 0.0 0.021 14.3 0.0 1.2 1 0 0 1 1 1 0 Apolipoprotein CIII (Apo-CIII) p450 PF00067.20 001204437.1_08023001_1 - 7.6e-163 542.4 0.0 8.6e-163 542.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ribosomal_L9_N PF01281.17 001204437.1_08023001_1 - 0.1 12.0 0.0 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L9, N-terminal domain Fip1 PF05182.11 001270926.1_08025001_2 - 2.3e-25 87.7 2.1 6.9e-25 86.1 2.1 1.9 1 0 0 1 1 1 1 Fip1 motif NESP55 PF06390.10 001270926.1_08025001_3 - 0.021 14.3 1.8 0.032 13.7 1.8 1.2 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) NDK PF00334.17 001204877.1_08022001_1 - 2.5e-55 186.1 0.0 3.1e-55 185.8 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Cytochrom_B561 PF03188.14 001190736.1_29622001_1 - 7.4e-44 149.1 4.7 1.3e-43 148.3 4.7 1.4 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 Nitrate_red_gam PF02665.12 001190736.1_29622001_1 - 0.00061 19.3 1.2 0.001 18.6 1.2 1.5 1 1 0 1 1 1 1 Nitrate reductase gamma subunit DUF2243 PF10002.7 001190736.1_29622001_1 - 0.0024 17.8 0.1 0.0057 16.6 0.1 1.8 1 0 0 1 1 1 1 Predicted membrane protein (DUF2243) PIG-F PF06699.9 001190736.1_29622001_1 - 0.026 14.5 5.0 0.25 11.4 0.2 2.3 1 1 1 2 2 2 0 GPI biosynthesis protein family Pig-F DUF2214 PF09980.7 001190736.1_29622001_1 - 0.049 13.3 3.3 0.11 12.2 3.3 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2214) DUF4079 PF13301.4 001190736.1_29622001_1 - 0.078 13.0 8.7 0.31 11.0 8.4 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) DUF1129 PF06570.9 001190736.1_29622001_1 - 0.13 11.6 1.0 0.46 9.8 0.6 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1129) DUF2427 PF10348.7 001190736.1_29622001_1 - 0.8 9.4 4.6 0.31 10.7 0.7 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF2427) Ni_hydr_CYTB PF01292.18 001190736.1_29622001_1 - 1.5 8.3 12.6 0.41 10.1 7.7 2.4 1 1 1 3 3 3 0 Prokaryotic cytochrome b561 Ig_5 PF16681.3 001257220.1_08022001_2 - 3.7e-35 120.1 0.8 5.5e-35 119.5 0.8 1.3 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 001257220.1_08022001_2 - 4.6e-19 68.4 0.4 7.5e-19 67.7 0.4 1.3 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 delta chain ITAM PF02189.13 001257220.1_08022001_2 - 2.1e-05 24.6 0.4 3.7e-05 23.8 0.4 1.4 1 0 0 1 1 1 1 Immunoreceptor tyrosine-based activation motif Ig_3 PF13927.4 001257220.1_08022001_2 - 0.072 13.6 0.4 0.22 12.0 0.1 1.9 2 0 0 2 2 2 0 Immunoglobulin domain P5-ATPase PF12409.6 001257220.1_08022001_2 - 0.075 13.0 0.1 0.16 11.9 0.1 1.5 1 0 0 1 1 1 0 P5-type ATPase cation transporter Ribosomal_L22e PF01776.15 001193564.1_29624001_1 - 2.7e-52 175.6 1.0 4e-52 175.1 1.0 1.2 1 0 0 1 1 1 1 Ribosomal L22e protein family BCDHK_Adom3 PF10436.7 001159306.1_49828001_2 - 5.9e-50 169.1 0.3 9e-50 168.5 0.3 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.24 001159306.1_49828001_2 - 3.5e-14 53.2 0.0 5.7e-14 52.5 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase UPF0220 PF05255.9 001246571.1_39725001_3 - 3.5e-49 166.4 3.9 4.9e-49 165.9 3.9 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) 7tm_1 PF00001.19 001204766.1_49823001_2 - 6.3e-36 123.9 14.8 8.2e-36 123.5 14.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PMP22_Claudin PF00822.18 001265948.1_29622001_1 - 9.5e-54 181.6 16.1 1.1e-53 181.4 16.1 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001265948.1_29622001_1 - 3.9e-08 33.1 18.4 2.5e-07 30.5 15.8 2.5 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction 7TMR-DISM_7TM PF07695.9 001265948.1_29622001_1 - 0.0023 17.7 7.4 0.0023 17.7 7.4 2.0 2 1 0 2 2 2 1 7TM diverse intracellular signalling Amastin PF07344.9 001265948.1_29622001_1 - 0.007 16.1 9.6 0.007 16.1 9.6 1.8 1 1 0 2 2 2 1 Amastin surface glycoprotein Mem_trans PF03547.16 001265948.1_29622001_1 - 0.038 12.3 3.3 0.058 11.7 3.3 1.3 1 0 0 1 1 1 0 Membrane transport protein Clc-like PF07062.10 001265948.1_29622001_1 - 0.4 10.0 16.6 0.084 12.2 9.2 2.0 1 1 1 2 2 2 0 Clc-like Claudin_3 PF06653.9 001265948.1_29622001_1 - 1 9.1 19.3 4.6 7.0 19.3 1.7 1 1 0 1 1 1 0 Tight junction protein, Claudin-like DUF4131 PF13567.4 001265948.1_29622001_1 - 6.7 6.2 8.0 0.15 11.5 0.3 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Ribosomal_L32p PF01783.21 001265948.1_29622001_3 - 0.0079 16.3 14.4 0.042 14.0 6.4 2.5 2 0 0 2 2 2 2 Ribosomal L32p protein family Troponin-I_N PF11636.6 001265948.1_29622001_3 - 0.84 9.5 7.4 1.5 8.7 7.4 1.4 1 0 0 1 1 1 0 Troponin I residues 1-32 GFO_IDH_MocA PF01408.20 001260710.1_29624001_1 - 2.4e-12 47.6 0.0 6.6e-12 46.2 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold F420_oxidored PF03807.15 001260710.1_29624001_1 - 0.006 17.0 0.0 0.016 15.7 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.18 001260710.1_29624001_1 - 0.088 12.7 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase GFO_IDH_MocA_C PF02894.15 001260710.1_29624001_1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain Abhydrolase_1 PF00561.18 001266007.1_29625001_2 - 1.4e-24 87.0 0.1 4.6e-24 85.3 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001266007.1_29625001_2 - 5.7e-18 66.2 0.0 9.7e-18 65.4 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 001266007.1_29625001_2 - 1.1e-15 57.4 0.0 2.7e-15 56.2 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.12 001266007.1_29625001_2 - 8.5e-06 24.5 0.1 2.2e-05 23.2 0.1 1.6 1 1 0 1 1 1 1 Ndr family BAAT_C PF08840.9 001266007.1_29625001_2 - 0.006 16.4 0.1 0.026 14.3 0.0 1.8 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal DUF1057 PF06342.10 001266007.1_29625001_2 - 0.0075 15.2 0.0 0.011 14.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) FSH1 PF03959.11 001266007.1_29625001_2 - 0.0094 15.5 0.1 0.76 9.3 0.0 2.4 2 1 1 3 3 3 1 Serine hydrolase (FSH1) DLH PF01738.16 001266007.1_29625001_2 - 0.015 14.8 0.0 0.3 10.5 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Thioesterase PF00975.18 001266007.1_29625001_2 - 0.16 11.9 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain IRF-3 PF10401.7 001267018.1_29625001_3 - 3.3e-67 225.6 0.0 4.5e-67 225.2 0.0 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 IRF PF00605.15 001267018.1_29625001_3 - 3.7e-38 129.9 0.1 6.4e-38 129.1 0.1 1.4 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor Ras PF00071.20 001287233.1_09023001_1 - 1.6e-56 190.3 0.3 2e-56 189.9 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001287233.1_09023001_1 - 5.3e-20 71.7 0.0 7.8e-20 71.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001287233.1_09023001_1 - 2.7e-08 33.3 0.2 3.4e-08 33.0 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001287233.1_09023001_1 - 0.00045 19.7 0.2 0.0011 18.5 0.1 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001287233.1_09023001_1 - 0.0031 17.5 0.0 0.0046 16.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001287233.1_09023001_1 - 0.01 15.6 2.2 2.2 8.0 0.0 2.2 1 1 0 2 2 2 0 Protein of unknown function, DUF258 Shadoo PF14999.4 001287233.1_09023001_2 - 0.04 13.9 7.5 0.058 13.4 7.5 1.2 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective SRF-TF PF00319.16 001266447.1_29629001_2 - 1.7e-23 81.7 0.4 4e-23 80.5 0.4 1.7 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.6 001266447.1_29629001_2 - 1.5e-15 56.8 0.1 3.5e-15 55.6 0.1 1.6 1 0 0 1 1 1 1 Holliday junction regulator protein family C-terminal repeat NIF PF03031.16 001266058.1_29629001_1 - 2.1e-51 173.7 0.0 2.8e-51 173.2 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase TFIIF_beta PF02270.13 001266711.2_29623001_1 - 5.3e-59 200.5 1.1 2.3e-41 142.7 3.3 2.0 1 1 1 2 2 2 2 Transcription initiation factor IIF, beta subunit WW PF00397.24 001267881.2_39524001_1 - 1.3e-21 76.1 0.9 2.3e-10 40.1 0.1 2.4 2 0 0 2 2 2 2 WW domain FAM181 PF15238.4 001267881.2_39524001_1 - 0.0003 20.6 0.6 0.00057 19.7 0.6 1.5 1 0 0 1 1 1 1 FAM181 MbtH PF03621.11 001267881.2_39524001_1 - 0.02 14.2 0.0 0.98 8.8 0.0 2.3 2 0 0 2 2 2 0 MbtH-like protein Tmemb_185A PF10269.7 001257432.1_29626001_3 - 4.4e-61 206.6 29.0 7.1e-61 205.9 29.0 1.3 1 0 0 1 1 1 1 Transmembrane Fragile-X-F protein Aldolase_II PF00596.19 001261471.1_29628001_1 - 9.1e-44 149.5 0.1 1.7e-43 148.6 0.1 1.5 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain NMU PF02070.13 001267744.1_08022001_2 - 2.8e-14 52.6 4.3 5.1e-14 51.7 4.3 1.5 1 0 0 1 1 1 1 Neuromedin U VWA PF00092.26 001267739.1_08028001_2 - 2.1e-43 148.5 0.3 3.4e-43 147.8 0.3 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Integrin_alpha2 PF08441.10 001267739.1_08028001_2 - 1.3e-36 126.3 0.0 1.9e-36 125.8 0.0 1.2 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.21 001267739.1_08028001_2 - 2.5e-20 72.1 5.7 2.3e-07 30.7 0.6 4.1 4 0 0 4 4 4 3 FG-GAP repeat VWA_2 PF13519.4 001267739.1_08028001_2 - 3.9e-16 59.5 0.1 1e-15 58.2 0.1 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VCBS PF13517.4 001267739.1_08028001_2 - 2.5e-06 27.8 0.1 0.012 16.0 0.1 3.6 2 1 1 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.18 001267739.1_08028001_2 - 5.7e-06 25.8 0.9 1.5e-05 24.5 0.9 1.7 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region FG-GAP_2 PF14312.4 001267739.1_08028001_2 - 0.17 12.1 8.6 8.4 6.6 0.1 4.0 4 0 0 4 4 4 0 FG-GAP repeat DUF3652 PF12372.6 001267745.1_08029001_1 - 1.4e-21 75.9 0.7 5.2e-21 74.1 0.7 2.1 1 0 0 1 1 1 1 Huntingtin protein region HEAT PF02985.20 001267745.1_08029001_1 - 9.4e-09 34.6 7.5 0.04 14.0 0.0 7.6 7 0 0 7 7 7 2 HEAT repeat HEAT_2 PF13646.4 001267745.1_08029001_1 - 9.7e-06 25.8 1.0 0.35 11.1 0.3 5.4 3 2 3 6 6 6 2 HEAT repeats Vac14_Fab1_bd PF12755.5 001267745.1_08029001_1 - 0.0015 19.0 0.2 1.3 9.5 0.0 3.6 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.4 001267745.1_08029001_1 - 0.012 16.0 8.2 5.5 7.4 0.3 6.3 5 1 2 7 7 7 0 HEAT-like repeat Arm PF00514.21 001267745.1_08029001_1 - 0.044 13.7 1.7 59 3.8 0.1 5.0 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat PRANC PF09372.8 001267745.1_08029001_1 - 0.2 11.9 0.5 3.7 7.8 0.2 2.7 2 0 0 2 2 2 0 PRANC domain AhpC-TSA PF00578.19 001280704.1_39524001_1 - 8.1e-29 99.9 0.0 1.1e-28 99.5 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.7 001280704.1_39524001_1 - 2.1e-10 40.1 0.1 3.5e-10 39.4 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Redoxin PF08534.8 001280704.1_39524001_1 - 2.7e-10 40.0 0.0 3.9e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Redoxin Gmad1 PF10647.7 001280704.1_39524001_1 - 0.11 12.1 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 Lipoprotein LpqB beta-propeller domain Methyltransf_16 PF10294.7 001266262.1_29623001_3 - 1.2e-11 44.5 0.0 8.1e-05 22.3 0.0 2.2 2 0 0 2 2 2 2 Lysine methyltransferase PrmA PF06325.11 001266262.1_29623001_3 - 2.5e-07 30.2 0.0 4e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.4 001266262.1_29623001_3 - 4.5e-07 29.8 0.0 7.1e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 001266262.1_29623001_3 - 1e-05 25.3 0.1 0.11 12.2 0.1 2.3 2 0 0 2 2 2 2 Methyltransferase domain MTS PF05175.12 001266262.1_29623001_3 - 6.1e-05 22.5 0.0 0.0001 21.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.10 001266262.1_29623001_3 - 0.0013 19.3 0.0 0.0028 18.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.13 001266262.1_29623001_3 - 0.0019 17.8 0.0 0.0032 17.0 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_25 PF13649.4 001266262.1_29623001_3 - 0.044 14.4 0.1 0.19 12.4 0.1 2.2 1 1 0 1 1 1 0 Methyltransferase domain FRG1 PF06229.10 001261228.1_29622001_2 - 1e-78 263.3 0.2 1e-78 263.3 0.2 1.8 2 0 0 2 2 2 1 FRG1-like domain Fascin PF06268.11 001261228.1_29622001_2 - 6.9e-07 29.3 0.0 2e-06 27.9 0.0 1.8 1 1 0 1 1 1 1 Fascin domain DUF569 PF04601.11 001261228.1_29622001_2 - 0.0033 17.0 0.0 0.082 12.5 0.0 2.9 1 1 1 2 2 2 1 Domain of unknown function (DUF569) DUF2235 PF09994.7 001261228.1_29622001_2 - 0.012 14.8 0.0 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) EF-hand_1 PF00036.30 001266092.2_29622001_3 - 3.8e-25 85.4 17.3 1.6e-08 33.4 0.9 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 001266092.2_29622001_3 - 1.1e-24 86.5 12.5 6.4e-14 52.1 2.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 001266092.2_29622001_3 - 5.9e-22 75.6 12.6 2.8e-06 26.7 0.3 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.4 001266092.2_29622001_3 - 1.5e-15 56.6 14.1 1.1e-10 41.0 0.8 3.9 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.4 001266092.2_29622001_3 - 2.5e-13 48.8 13.9 0.00024 20.3 0.7 4.4 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.4 001266092.2_29622001_3 - 3.6e-08 33.5 1.3 0.00044 20.4 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 001266092.2_29622001_3 - 0.00011 22.0 5.4 0.011 15.6 0.5 2.5 1 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.11 001266092.2_29622001_3 - 0.014 15.2 1.4 1.6 8.5 0.0 3.5 1 1 3 4 4 4 0 Caleosin related protein HTH_40 PF14493.4 001266092.2_29622001_3 - 0.045 14.1 2.2 4.3 7.8 0.0 2.3 1 1 1 2 2 2 0 Helix-turn-helix domain SPARC_Ca_bdg PF10591.7 001266092.2_29622001_3 - 0.1 12.8 5.3 0.93 9.7 1.2 2.2 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Relaxase PF03432.12 001266092.2_29622001_3 - 0.29 10.6 3.1 0.35 10.3 2.2 1.4 1 1 0 1 1 1 0 Relaxase/Mobilisation nuclease domain MgtE_N PF03448.15 001266092.2_29622001_3 - 0.47 10.9 4.6 0.21 12.1 0.6 2.3 1 1 2 3 3 3 0 MgtE intracellular N domain 7tm_1 PF00001.19 001257216.1_08023001_1 - 2.1e-47 161.5 22.9 3.5e-47 160.8 22.9 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001257216.1_08023001_1 - 7.1e-08 32.0 23.1 9.6e-08 31.6 23.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001257216.1_08023001_1 - 1.4 8.5 19.4 7.6 6.0 19.4 2.3 1 1 0 1 1 1 0 Olfactory receptor zf-RING_2 PF13639.4 001260820.1_29628001_3 - 5.1e-07 29.7 9.9 1.4e-06 28.3 9.9 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.23 001260820.1_29628001_3 - 8.2e-07 28.7 8.9 2.3e-06 27.2 8.9 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001260820.1_29628001_3 - 3.8e-06 26.5 6.5 8.3e-06 25.4 6.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001260820.1_29628001_3 - 8e-06 25.6 9.8 1e-05 25.3 5.9 3.1 2 1 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.4 001260820.1_29628001_3 - 1.7e-05 24.6 6.8 1.7e-05 24.6 6.8 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.4 001260820.1_29628001_3 - 2.8e-05 23.7 9.0 8.3e-05 22.2 9.0 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 001260820.1_29628001_3 - 0.00035 20.2 7.0 0.0013 18.4 6.9 2.0 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.5 001260820.1_29628001_3 - 0.039 13.9 5.5 0.078 12.9 5.5 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger GCS2 PF04107.11 001260820.1_29628001_3 - 0.069 12.3 0.1 0.12 11.5 0.1 1.3 1 0 0 1 1 1 0 Glutamate-cysteine ligase family 2(GCS2) zf-RING_6 PF14835.4 001260820.1_29628001_3 - 0.075 12.8 4.4 0.29 10.9 4.4 2.0 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.4 001260820.1_29628001_3 - 0.22 11.6 14.6 0.025 14.6 9.4 2.3 2 0 0 2 2 1 0 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.5 001260820.1_29628001_3 - 0.31 11.2 10.3 0.66 10.2 10.3 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain LURAP PF14854.4 001266426.2_29622001_1 - 1.1e-51 173.6 0.2 1.4e-51 173.2 0.2 1.2 1 0 0 1 1 1 1 Leucine rich adaptor protein DUF4530 PF15039.4 001266426.2_29622001_1 - 0.001 19.1 0.2 0.0019 18.2 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4530) Spot_14 PF07084.10 001283482.1_29525001_1 - 1.2e-63 213.7 0.0 1.5e-63 213.4 0.0 1.1 1 0 0 1 1 1 1 Thyroid hormone-inducible hepatic protein Spot 14 CybS PF05328.10 001261763.1_29623001_2 - 1.9e-22 79.3 0.3 2.7e-22 78.7 0.3 1.2 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit Urm1 PF09138.9 001266132.1_29623001_1 - 2.8e-38 130.1 0.0 3.5e-38 129.7 0.0 1.1 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.18 001266132.1_29623001_1 - 0.032 14.7 0.0 0.047 14.2 0.0 1.2 1 0 0 1 1 1 0 ThiS family eIF-1a PF01176.17 001283992.1_29523001_3 - 3.4e-18 65.1 0.1 5.2e-18 64.5 0.1 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Pribosyltran_N PF13793.4 001260582.1_29625001_1 - 1.1e-47 160.7 0.6 2e-47 159.8 0.1 1.7 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.4 001260582.1_29625001_1 - 1.2e-42 146.0 2.6 2.7e-36 125.2 1.2 2.2 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.25 001260582.1_29625001_1 - 3.5e-13 49.2 0.3 1e-12 47.7 0.2 1.7 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.4 001260582.1_29625001_1 - 0.0016 17.8 0.1 0.0026 17.1 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase TMEM40 PF15817.3 001283345.1_29525001_3 - 0.024 14.2 0.1 0.056 13.0 0.1 1.5 1 0 0 1 1 1 0 Transmembrane protein 40 family Clathrin_bdg PF15045.4 001257727.1_29628001_3 - 8.4e-21 73.6 0.0 2.5e-20 72.1 0.0 1.9 1 0 0 1 1 1 1 Clathrin-binding box of Aftiphilin, vesicle trafficking ApoLp-III PF07464.9 001257727.1_29628001_3 - 0.081 12.9 0.2 0.25 11.3 0.2 1.8 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) Ras PF00071.20 001261511.1_29623001_2 - 1.6e-58 196.8 0.0 2e-58 196.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001261511.1_29623001_2 - 8.4e-31 106.6 0.0 1.5e-30 105.7 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001261511.1_29623001_2 - 2.4e-12 46.5 0.0 3.4e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001261511.1_29623001_2 - 7.6e-06 25.9 0.0 1.3e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001261511.1_29623001_2 - 0.00045 19.5 0.0 0.00065 19.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF258 PF03193.14 001261511.1_29623001_2 - 0.0031 17.3 0.0 1.7 8.4 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 CENP-M PF11111.6 001261511.1_29623001_2 - 0.11 11.5 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Centromere protein M (CENP-M) GTP_EFTU PF00009.25 001261511.1_29623001_2 - 0.15 11.5 0.0 0.63 9.4 0.0 1.8 1 1 0 2 2 2 0 Elongation factor Tu GTP binding domain Pkinase_Tyr PF07714.15 001266302.1_29628001_1 - 7.1e-63 212.2 0.0 9.4e-63 211.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001266302.1_29628001_1 - 1.7e-60 204.5 0.0 2.2e-60 204.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain RBD PF02196.13 001266302.1_29628001_1 - 1.8e-28 98.3 0.1 3.5e-28 97.4 0.1 1.5 1 0 0 1 1 1 1 Raf-like Ras-binding domain C1_1 PF00130.20 001266302.1_29628001_1 - 4.3e-12 45.6 8.5 1e-11 44.4 8.5 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.4 001266302.1_29628001_1 - 1.3e-06 27.9 0.0 1.8e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like zf-RING-like PF08746.9 001266302.1_29628001_1 - 0.00042 20.4 4.3 0.0013 18.9 4.3 1.9 1 0 0 1 1 1 1 RING-like domain zf-RING_2 PF13639.4 001266302.1_29628001_1 - 0.28 11.4 7.2 0.94 9.7 7.2 1.9 1 0 0 1 1 1 0 Ring finger domain C1_2 PF03107.14 001266302.1_29628001_1 - 0.69 10.1 8.3 0.12 12.5 4.0 2.0 2 0 0 2 2 2 0 C1 domain Zf_RING PF16744.3 001266302.1_29628001_1 - 1.2 9.1 3.6 3.8 7.6 3.6 1.8 1 0 0 1 1 1 0 KIAA1045 RING finger zf-C3HC4_2 PF13923.4 001266302.1_29628001_1 - 2.7 7.8 10.4 0.34 10.6 5.8 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) muHD PF10291.7 001257784.1_29629001_2 - 5.5e-67 225.8 0.0 8.1e-67 225.3 0.0 1.3 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.21 001257784.1_29629001_2 - 1.1e-18 67.1 0.0 1.1e-18 67.1 0.0 2.4 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain DUF1664 PF07889.10 001257784.1_29629001_2 - 2.3 8.1 10.8 1.9 8.4 2.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF747 PF05346.9 001266589.1_29626001_3 - 1.4e-107 359.8 19.2 1.8e-107 359.4 19.2 1.1 1 0 0 1 1 1 1 Eukaryotic membrane protein family DASH_Dad4 PF08650.8 001266589.1_29626001_3 - 0.19 11.6 3.9 0.58 10.0 2.2 2.3 2 0 0 2 2 2 0 DASH complex subunit Dad4 DUF4499 PF14934.4 001266368.1_29621001_1 - 2.9e-35 120.4 6.6 4.7e-35 119.7 6.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4499) Mito_carr PF00153.25 001257616.3_29624001_2 - 1.3e-65 217.2 0.9 1.5e-20 72.8 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein ABA_GPCR PF12430.6 001257436.2_29625001_2 - 1.1e-41 142.4 12.3 1.1e-41 142.4 12.3 2.0 2 0 0 2 2 2 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.6 001257436.2_29625001_2 - 1.5e-28 98.5 0.5 3.2e-28 97.5 0.1 1.8 2 0 0 2 2 2 1 The Golgi pH Regulator (GPHR) Family N-terminal NPCC PF08058.9 001257436.2_29625001_2 - 0.77 9.7 0.0 0.77 9.7 0.0 3.3 3 0 0 3 3 3 0 Nuclear pore complex component IL6Ra-bind PF09240.8 001267756.1_08023001_1 - 1.9e-18 66.5 0.3 4.2e-18 65.4 0.3 1.6 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding Ig_3 PF13927.4 001267756.1_08023001_1 - 1.1e-06 29.0 0.0 1.1e-05 25.8 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001267756.1_08023001_1 - 7.8e-06 25.8 0.0 2.2e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001267756.1_08023001_1 - 0.00022 21.4 0.0 0.0009 19.4 0.0 2.0 1 0 0 1 1 1 1 Immunoglobulin domain fn3 PF00041.19 001267756.1_08023001_1 - 0.0088 16.2 1.9 0.011 16.0 0.3 2.0 2 0 0 2 2 2 1 Fibronectin type III domain V-set PF07686.15 001267756.1_08023001_1 - 0.039 14.0 0.1 15 5.6 0.0 3.1 3 0 0 3 3 3 0 Immunoglobulin V-set domain BTB PF00651.29 001266403.1_29626001_3 - 3.7e-25 88.2 0.0 7.8e-25 87.1 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.13 001266403.1_29626001_3 - 1.3e-17 63.6 0.3 1.3e-17 63.6 0.3 1.6 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_1 PF01344.23 001266403.1_29626001_3 - 1.6e-13 49.9 8.4 6.8e-09 35.0 0.0 6.3 6 0 0 6 6 6 2 Kelch motif Kelch_6 PF13964.4 001266403.1_29626001_3 - 1.1e-10 41.3 1.1 2.1e-06 27.7 0.0 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.4 001266403.1_29626001_3 - 9.3e-09 35.2 0.2 0.0007 19.7 0.0 4.2 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_4 PF13418.4 001266403.1_29626001_3 - 2.2e-08 33.8 0.1 0.00024 20.8 0.0 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.13 001266403.1_29626001_3 - 4.4e-05 23.2 0.3 0.0049 16.7 0.0 4.0 4 0 0 4 4 4 1 Kelch motif DUF3342 PF11822.6 001266403.1_29626001_3 - 0.0068 16.5 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Forkhead PF00250.16 001267740.1_08026001_1 - 2.8e-26 91.5 0.2 5e-26 90.7 0.2 1.4 1 0 0 1 1 1 1 Forkhead domain FOXP-CC PF16159.3 001267740.1_08026001_1 - 4.3e-26 91.2 3.5 1.1e-25 89.9 3.5 1.8 1 0 0 1 1 1 1 FOXP coiled-coil domain bZIP_1 PF00170.19 001266010.1_29622001_3 - 2.2e-11 43.5 18.4 3.5e-11 42.9 18.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 001266010.1_29622001_3 - 1e-09 38.1 19.5 1.5e-09 37.7 19.5 1.2 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 001266010.1_29622001_3 - 2.5e-07 31.0 8.8 4.1e-07 30.3 8.8 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor Nnf1 PF03980.12 001266010.1_29622001_3 - 0.013 15.8 4.0 0.019 15.2 4.0 1.3 1 0 0 1 1 1 0 Nnf1 APG6 PF04111.10 001266010.1_29622001_3 - 0.25 10.6 7.0 0.32 10.2 7.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Afi1 PF07792.10 001266010.1_29622001_3 - 0.26 11.7 2.8 0.47 10.8 2.8 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Kinetocho_Slk19 PF12709.5 001266010.1_29622001_3 - 0.27 11.6 6.2 0.43 10.9 6.2 1.3 1 0 0 1 1 1 0 Central kinetochore-associated Ribosomal_L6e PF01159.17 001266010.1_29622001_3 - 0.48 10.8 4.3 0.22 11.9 2.1 1.5 2 0 0 2 2 2 0 Ribosomal protein L6e DivIC PF04977.13 001266010.1_29622001_3 - 0.67 9.6 6.2 1.2 8.9 6.2 1.4 1 0 0 1 1 1 0 Septum formation initiator Macoilin PF09726.7 001266010.1_29622001_3 - 0.83 8.0 7.8 1.1 7.6 7.8 1.1 1 0 0 1 1 1 0 Transmembrane protein DTW PF03942.13 001261379.1_29625001_2 - 3.2e-43 147.6 0.7 4.2e-43 147.2 0.7 1.1 1 0 0 1 1 1 1 DTW domain Myb_Cef PF11831.6 001261272.1_29626001_2 - 1.1e-82 277.1 6.6 1.1e-82 277.1 6.6 3.4 4 0 0 4 4 4 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.29 001261272.1_29626001_2 - 4.6e-21 74.6 7.2 6.5e-12 45.3 1.9 2.9 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 001261272.1_29626001_2 - 1.5e-18 66.6 9.2 1.1e-13 51.0 4.7 3.1 2 1 1 3 3 3 2 Myb-like DNA-binding domain Rap1_C PF11626.6 001261272.1_29626001_2 - 0.023 14.6 0.2 0.13 12.2 0.2 2.4 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Pox_A_type_inc PF04508.10 001261272.1_29626001_2 - 5.7 6.8 8.4 1.5 8.7 2.2 3.0 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Tmemb_cc2 PF10267.7 001261150.1_29629001_2 - 3.3e-166 553.2 13.7 6.1e-166 552.3 13.7 1.4 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein ATF7IP_BD PF16788.3 001261150.1_29629001_2 - 0.0057 16.8 2.4 0.0057 16.8 2.4 2.4 2 0 0 2 2 2 1 ATF-interacting protein binding domain UPF0565 PF10561.7 001261150.1_29629001_2 - 3.2 6.7 8.3 0.14 11.2 0.4 2.3 2 1 0 2 2 2 0 Uncharacterised protein family UPF0565 Exonuc_VII_L PF02601.13 001261150.1_29629001_2 - 8.6 5.7 25.0 1.7 8.0 1.6 2.6 3 0 0 3 3 3 0 Exonuclease VII, large subunit DNA_binding_1 PF01035.18 001257605.2_29622001_2 - 2.7e-28 97.7 0.0 4.3e-28 97.1 0.0 1.3 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N PF02870.13 001257605.2_29622001_2 - 3.5e-22 78.9 0.1 5.4e-22 78.3 0.1 1.3 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain PSS PF03034.13 001257822.1_29625001_2 - 1.1e-105 353.2 21.7 1.1e-105 353.2 21.7 1.8 2 0 0 2 2 2 1 Phosphatidyl serine synthase CART PF06373.9 001261725.2_29622001_2 - 2.3 8.3 4.6 12 6.0 0.7 2.2 2 0 0 2 2 2 0 Cocaine and amphetamine regulated transcript protein (CART) Rpp20 PF12328.6 001261725.2_29622001_3 - 1e-19 70.7 0.0 8.3e-18 64.5 0.0 2.2 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.19 001261725.2_29622001_3 - 4.1e-09 36.0 0.0 6e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Alba BCIP PF13862.4 001265671.1_29623001_1 - 7.1e-57 192.4 4.5 1.4e-56 191.5 4.5 1.5 1 0 0 1 1 1 1 p21-C-terminal region-binding protein DNA_pol_phi PF04931.11 001265671.1_29623001_1 - 0.018 13.0 17.3 0.03 12.3 17.3 1.4 1 0 0 1 1 1 0 DNA polymerase phi FAM176 PF14851.4 001265671.1_29623001_1 - 4.7 6.8 9.5 3 7.4 6.0 2.1 2 0 0 2 2 2 0 FAM176 family PB1 PF00564.22 001266564.2_29623001_1 - 9.7e-13 47.7 0.0 1.5e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 PB1 domain PDZ PF00595.22 001266564.2_29623001_1 - 3.6e-10 39.9 0.1 6.2e-10 39.2 0.1 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PMG PF05287.10 001285771.1_09022001_3 - 3.8e-21 75.8 29.4 3.1e-19 69.6 29.4 2.2 1 1 0 1 1 1 1 PMG protein Keratin_B2_2 PF13885.4 001285771.1_09022001_3 - 5.7 6.8 20.4 1.3 8.9 3.5 3.4 3 0 0 3 3 3 0 Keratin, high sulfur B2 protein Ras PF00071.20 001261123.1_29623001_3 - 1.6e-57 193.5 0.0 2.1e-57 193.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001261123.1_29623001_3 - 1.6e-36 125.0 0.0 3e-36 124.2 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001261123.1_29623001_3 - 2.3e-14 53.1 0.0 3.3e-14 52.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001261123.1_29623001_3 - 1e-08 34.7 0.0 1.4e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001261123.1_29623001_3 - 4.9e-05 23.3 0.0 7.5e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001261123.1_29623001_3 - 0.0001 22.1 0.3 0.16 11.7 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001261123.1_29623001_3 - 0.00015 21.3 0.0 0.00075 19.0 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.15 001261123.1_29623001_3 - 0.00045 19.9 0.6 0.046 13.4 0.1 2.3 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein FeoB_N PF02421.16 001261123.1_29623001_3 - 0.0044 16.4 0.2 0.018 14.4 0.2 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.8 001261123.1_29623001_3 - 0.0051 16.1 0.0 0.0075 15.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA PF00004.27 001261123.1_29623001_3 - 0.0053 17.1 0.0 0.017 15.4 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.4 001261123.1_29623001_3 - 0.015 15.4 0.0 0.023 14.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.12 001261123.1_29623001_3 - 0.017 15.0 0.1 0.037 13.9 0.1 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.10 001261123.1_29623001_3 - 0.032 14.0 0.1 0.063 13.1 0.1 1.4 1 0 0 1 1 1 0 NACHT domain PduV-EutP PF10662.7 001261123.1_29623001_3 - 0.032 13.8 0.2 0.14 11.7 0.2 1.9 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.15 001261123.1_29623001_3 - 0.036 13.9 0.2 0.25 11.2 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.4 001261123.1_29623001_3 - 0.042 14.0 0.1 0.1 12.8 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 001261123.1_29623001_3 - 0.049 13.9 0.1 0.081 13.2 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain DnaJ PF00226.29 001257911.1_29624001_3 - 1.9e-28 98.3 4.0 2.9e-28 97.6 4.0 1.3 1 0 0 1 1 1 1 DnaJ domain Pkinase PF00069.23 001260967.1_29625001_1 - 7.4e-72 241.7 0.0 1.1e-71 241.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001260967.1_29625001_1 - 2e-52 177.9 0.0 3.6e-52 177.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Mst1_SARAH PF11629.6 001260967.1_29625001_1 - 5e-25 87.2 5.1 5e-25 87.2 5.1 2.0 2 0 0 2 2 2 1 C terminal SARAH domain of Mst1 Abi_2 PF07751.9 001260967.1_29625001_1 - 0.026 14.7 0.0 0.077 13.1 0.0 1.8 1 0 0 1 1 1 0 Abi-like protein RRM_1 PF00076.20 001257505.1_29623001_3 - 8.3e-29 99.1 1.2 2.1e-14 52.9 0.1 2.5 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001257505.1_29623001_3 - 1.4e-07 31.1 0.0 0.00066 19.4 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_5 PF13893.4 001257505.1_29623001_3 - 1.7e-07 30.8 0.0 0.01 15.3 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4523 PF15023.4 001257505.1_29623001_3 - 0.0083 15.8 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4523) XRCC4 PF06632.10 001267765.1_08023001_1 - 2.3e-153 509.9 6.4 2.5e-153 509.7 6.4 1.0 1 0 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF2383 PF09537.8 001267765.1_08023001_1 - 0.026 14.8 0.0 0.9 9.8 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF2383) Phage_HK97_TLTM PF06120.9 001267765.1_08023001_1 - 0.054 12.5 0.2 0.076 12.0 0.2 1.3 1 0 0 1 1 1 0 Tail length tape measure protein EpoR_lig-bind PF09067.8 001285669.1_09024001_1 - 6e-23 80.9 0.0 1.8e-22 79.4 0.0 1.8 2 0 0 2 2 2 1 Erythropoietin receptor, ligand binding fn3 PF00041.19 001285669.1_09024001_1 - 5.5e-09 36.1 0.1 0.00064 19.9 0.1 3.3 3 1 0 3 3 3 2 Fibronectin type III domain IL6Ra-bind PF09240.8 001285669.1_09024001_1 - 1.3e-05 25.4 0.0 2.7e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding TNF PF00229.16 001205139.2_08022001_2 - 5.1e-16 58.6 0.0 7.6e-16 58.1 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1q PF00386.19 001205139.2_08022001_2 - 0.0049 16.9 0.0 0.0073 16.4 0.0 1.2 1 0 0 1 1 1 1 C1q domain Neurochondrin PF05536.9 001266697.1_29628001_2 - 2.7e-210 699.3 0.0 3.2e-210 699.0 0.0 1.0 1 0 0 1 1 1 1 Neurochondrin Rad1 PF02144.14 001261160.1_29625001_2 - 3.4e-83 278.7 1.2 4.3e-83 278.4 1.2 1.1 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Pro_3_hydrox_C PF05373.9 001261160.1_29625001_2 - 0.058 13.4 0.0 0.59 10.1 0.0 2.1 2 0 0 2 2 2 0 L-proline 3-hydroxylase, C-terminal Arfaptin PF06456.11 001265706.2_29625001_3 - 1.8e-91 305.7 10.3 2.6e-91 305.1 10.3 1.3 1 0 0 1 1 1 1 Arfaptin-like domain ICA69 PF04629.12 001265706.2_29625001_3 - 8.6e-61 206.3 15.4 1.9e-42 146.2 6.5 2.4 1 1 1 2 2 2 2 Islet cell autoantigen ICA69, C-terminal domain DAO PF01266.22 001261055.1_29629001_1 - 3.6e-47 161.5 0.0 4.5e-47 161.2 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.3 001261055.1_29629001_1 - 6.7e-40 135.7 0.0 1.1e-39 135.0 0.0 1.3 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase EF-hand_7 PF13499.4 001261055.1_29629001_1 - 2.6e-10 40.5 0.7 4.4e-10 39.8 0.7 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 001261055.1_29629001_1 - 2.9e-09 35.7 0.2 0.00023 20.3 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 001261055.1_29629001_1 - 3.6e-07 29.5 0.2 0.014 15.2 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain FAD_binding_2 PF00890.22 001261055.1_29629001_1 - 1.4e-06 27.5 0.4 0.00033 19.7 0.1 2.1 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.5 001261055.1_29629001_1 - 3.6e-05 23.1 0.4 7.8e-05 22.1 0.1 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase EF-hand_8 PF13833.4 001261055.1_29629001_1 - 4.9e-05 22.9 0.3 0.00011 21.7 0.2 1.8 1 1 0 1 1 1 1 EF-hand domain pair GIDA PF01134.20 001261055.1_29629001_1 - 5e-05 22.4 0.1 0.015 14.3 0.1 2.1 2 0 0 2 2 2 2 Glucose inhibited division protein A EF-hand_5 PF13202.4 001261055.1_29629001_1 - 0.0023 17.2 1.2 0.86 9.1 0.0 2.4 2 0 0 2 2 2 2 EF hand Pyr_redox_2 PF07992.12 001261055.1_29629001_1 - 0.0026 16.9 0.1 0.01 15.0 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase EF-hand_9 PF14658.4 001261055.1_29629001_1 - 0.0048 17.1 0.0 0.011 15.9 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_10 PF14788.4 001261055.1_29629001_1 - 0.062 13.0 0.3 0.14 11.9 0.3 1.6 1 0 0 1 1 1 0 EF hand HI0933_like PF03486.12 001261055.1_29629001_1 - 0.072 11.6 0.1 0.1 11.1 0.1 1.1 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_8 PF13450.4 001261055.1_29629001_1 - 0.099 12.8 0.1 0.25 11.5 0.1 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.17 001261055.1_29629001_1 - 0.26 10.4 0.8 2.1 7.4 0.9 1.9 1 1 0 1 1 1 0 FAD binding domain PCI PF01399.25 001265853.2_29624001_3 - 1.5e-23 83.2 2.9 2.1e-23 82.7 0.0 2.7 3 1 0 3 3 3 1 PCI domain PAS_11 PF14598.4 001257837.1_29626001_1 - 9.4e-26 90.0 0.2 4.9e-22 78.1 0.1 2.3 2 0 0 2 2 2 2 PAS domain PAS PF00989.23 001257837.1_29626001_1 - 1.5e-20 73.2 0.0 4e-09 36.3 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_3 PF08447.10 001257837.1_29626001_1 - 1.3e-19 70.1 0.0 1.1e-11 44.7 0.0 2.4 2 0 0 2 2 2 2 PAS fold HLH PF00010.24 001257837.1_29626001_1 - 2.8e-17 62.3 0.8 5e-17 61.5 0.8 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.5 001257837.1_29626001_1 - 2.7e-08 33.9 0.0 7.3e-05 22.9 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.8 001257837.1_29626001_1 - 5.8e-05 23.2 0.0 0.013 15.6 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS_2 PF08446.9 001257837.1_29626001_1 - 0.041 14.4 0.0 0.13 12.8 0.0 1.7 2 0 0 2 2 2 0 PAS fold ACBP PF00887.17 001258175.1_29622001_1 - 3.1e-27 94.5 0.1 4.3e-27 94.0 0.1 1.2 1 0 0 1 1 1 1 Acyl CoA binding protein SERTA PF06031.11 001261264.1_29623001_1 - 2.9e-14 52.3 1.7 4.5e-14 51.7 1.7 1.3 1 0 0 1 1 1 1 SERTA motif WIF PF02019.16 001260671.1_29625001_1 - 2e-33 114.8 0.0 3e-33 114.2 0.0 1.2 1 0 0 1 1 1 1 WIF domain EGF_2 PF07974.11 001260671.1_29625001_1 - 2.6e-14 53.1 93.0 0.0021 18.2 15.8 5.4 5 0 0 5 5 5 5 EGF-like domain hEGF PF12661.5 001260671.1_29625001_1 - 2.2e-11 43.9 66.1 0.0018 18.8 7.7 5.9 5 0 0 5 5 5 5 Human growth factor-like EGF EGF PF00008.25 001260671.1_29625001_1 - 5.2e-10 39.3 90.0 0.0011 19.0 10.0 5.5 5 0 0 5 5 5 5 EGF-like domain EpoR_lig-bind PF09067.8 001267737.1_08024001_2 - 7.9e-24 83.7 0.0 2.2e-23 82.3 0.0 1.8 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding fn3 PF00041.19 001267737.1_08024001_2 - 4e-08 33.3 2.0 0.00012 22.2 0.2 3.4 3 1 0 3 3 3 2 Fibronectin type III domain IL6Ra-bind PF09240.8 001267737.1_08024001_2 - 3.8e-07 30.3 0.0 1.1e-06 28.9 0.0 1.8 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding CRF-BP PF05428.9 001257453.1_29624001_3 - 5.3e-179 593.5 0.0 6.3e-179 593.2 0.0 1.1 1 0 0 1 1 1 1 Corticotropin-releasing factor binding protein (CRF-BP) V-SNARE_C PF12352.6 001266359.2_29623001_2 - 3.4e-20 72.0 8.0 3.4e-20 72.0 8.0 2.3 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.13 001266359.2_29623001_2 - 1.4e-18 66.9 0.4 1.4e-18 66.9 0.4 2.1 2 1 1 3 3 3 1 Vesicle transport v-SNARE protein N-terminus Sec20 PF03908.11 001266359.2_29623001_2 - 1.3e-05 24.9 1.6 3.3e-05 23.6 1.3 1.8 2 0 0 2 2 2 1 Sec20 Laminin_II PF06009.10 001266359.2_29623001_2 - 0.0021 17.9 3.3 0.22 11.4 0.8 2.8 2 1 0 3 3 3 1 Laminin Domain II YqjK PF13997.4 001266359.2_29623001_2 - 0.0096 16.0 1.3 5.2 7.3 0.4 2.4 2 0 0 2 2 2 2 YqjK-like protein Fusion_gly PF00523.16 001266359.2_29623001_2 - 0.012 13.8 0.4 0.02 13.0 0.4 1.3 1 0 0 1 1 1 0 Fusion glycoprotein F0 DUF3376 PF11856.6 001266359.2_29623001_2 - 0.014 14.2 1.0 0.025 13.4 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3376) DUF4407 PF14362.4 001266359.2_29623001_2 - 0.093 11.9 1.5 0.14 11.3 1.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF745 PF05335.11 001266359.2_29623001_2 - 0.53 9.9 5.6 3.1 7.4 2.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF745) OmpH PF03938.12 001266359.2_29623001_2 - 1.3 8.8 5.2 0.52 10.2 0.1 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF1759 PF03564.13 001266359.2_29623001_2 - 2.6 7.8 5.1 4.8 7.0 0.3 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1759) Exonuc_VII_L PF02601.13 001266359.2_29623001_2 - 4.4 6.7 10.1 13 5.0 10.1 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit KxDL PF10241.7 001266359.2_29623001_2 - 7.1 6.9 11.9 5.4 7.2 0.3 3.6 3 1 1 4 4 4 0 Uncharacterized conserved protein CorA PF01544.16 001266359.2_29623001_2 - 8.8 5.4 7.2 9.1 5.4 0.2 2.4 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein IF4E PF01652.16 001258071.1_29622001_1 - 3.9e-60 202.1 0.1 5.1e-60 201.7 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Glyoxalase PF00903.23 001265952.1_29623001_1 - 1.2e-08 35.1 0.0 0.0072 16.4 0.0 2.7 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.4 001265952.1_29623001_1 - 0.038 14.2 0.0 0.22 11.7 0.0 2.1 2 0 0 2 2 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CppA_N PF14506.4 001265952.1_29623001_1 - 0.044 13.7 0.0 0.29 11.1 0.0 2.1 2 0 0 2 2 2 0 CppA N-terminal TPR_12 PF13424.4 001261630.1_29626001_2 - 6.4e-65 215.3 29.0 6.1e-20 71.2 2.0 5.8 3 1 3 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.4 001261630.1_29626001_2 - 3.6e-55 182.3 17.9 3.1e-14 52.2 0.0 7.2 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.4 001261630.1_29626001_2 - 3.4e-24 82.9 18.2 9.3e-06 25.2 0.0 7.4 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_1 PF00515.26 001261630.1_29626001_2 - 2.3e-23 80.9 27.9 2.2e-07 30.3 0.5 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.15 001261630.1_29626001_2 - 2e-17 61.7 25.8 0.0011 18.8 0.4 6.6 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.4 001261630.1_29626001_2 - 2.6e-11 42.6 23.5 0.0024 17.8 0.1 6.9 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.4 001261630.1_29626001_2 - 9.8e-10 38.8 13.0 0.0018 18.8 0.1 5.1 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_19 PF14559.4 001261630.1_29626001_2 - 1.1e-09 38.5 14.1 0.00022 21.5 0.2 4.5 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.4 001261630.1_29626001_2 - 3.6e-07 30.0 8.9 0.022 15.0 0.2 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_4 PF07721.12 001261630.1_29626001_2 - 7.1e-07 29.1 1.4 35 5.3 0.0 7.1 7 0 0 7 7 7 0 Tetratricopeptide repeat ANAPC3 PF12895.5 001261630.1_29626001_2 - 7.2e-07 29.2 10.4 0.0049 16.9 0.6 3.3 2 1 2 4 4 3 2 Anaphase-promoting complex, cyclosome, subunit 3 SNAP PF14938.4 001261630.1_29626001_2 - 1.7e-06 27.5 1.0 3.6e-06 26.5 1.0 1.5 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_14 PF13428.4 001261630.1_29626001_2 - 4.1e-06 27.0 16.4 9.9 7.2 0.4 7.5 6 1 2 8 8 7 0 Tetratricopeptide repeat PPR PF01535.18 001261630.1_29626001_2 - 0.00021 21.2 0.1 0.11 12.7 0.0 3.6 4 0 0 4 4 2 1 PPR repeat JIP_LZII PF16471.3 001261630.1_29626001_2 - 0.0045 17.0 3.3 0.0098 15.9 3.3 1.5 1 0 0 1 1 1 1 JNK-interacting protein leucine zipper II TMF_TATA_bd PF12325.6 001261630.1_29626001_2 - 0.005 16.9 5.3 0.011 15.7 5.3 1.5 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding DUF627 PF04781.10 001261630.1_29626001_2 - 0.0085 16.0 0.3 0.53 10.2 0.1 2.8 1 1 1 2 2 2 1 Protein of unknown function (DUF627) Coatomer_E PF04733.12 001261630.1_29626001_2 - 0.01 15.1 1.0 1.5 8.1 0.1 2.6 1 1 1 2 2 2 0 Coatomer epsilon subunit DUF2225 PF09986.7 001261630.1_29626001_2 - 0.046 13.3 1.5 4.2 6.9 0.5 2.4 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) TMF_DNA_bd PF12329.6 001261630.1_29626001_2 - 0.053 13.4 5.5 0.14 12.1 5.5 1.7 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF972 PF06156.11 001261630.1_29626001_2 - 0.076 13.5 3.4 0.28 11.7 1.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF972) WbqC PF08889.9 001261630.1_29626001_2 - 0.087 12.6 0.1 5.5 6.7 0.0 2.9 1 1 2 3 3 3 0 WbqC-like protein family PPR_2 PF13041.4 001261630.1_29626001_2 - 0.091 12.8 0.8 5.1 7.2 0.0 3.3 4 0 0 4 4 2 0 PPR repeat family Clathrin PF00637.18 001261630.1_29626001_2 - 0.14 11.9 1.1 2.9 7.6 0.1 2.8 1 1 1 2 2 2 0 Region in Clathrin and VPS RPN7 PF10602.7 001261630.1_29626001_2 - 0.24 10.9 1.2 7.8 6.0 0.1 2.9 2 1 1 3 3 3 0 26S proteasome subunit RPN7 Spc7 PF08317.9 001261630.1_29626001_2 - 0.32 9.7 4.7 0.66 8.7 4.7 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein TPR_3 PF07720.10 001261630.1_29626001_2 - 0.46 10.4 10.6 4.3 7.3 0.7 4.1 4 0 0 4 4 3 0 Tetratricopeptide repeat COG2 PF06148.9 001261630.1_29626001_2 - 0.91 9.5 4.1 2.2 8.3 4.1 1.5 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 TPR_11 PF13414.4 001261630.1_29626001_2 - 1.3 8.7 14.6 0.8 9.3 0.4 5.4 5 0 0 5 5 5 0 TPR repeat SHNi-TPR PF10516.7 001261630.1_29626001_2 - 1.4 8.3 4.2 6.9 6.1 0.1 3.4 4 0 0 4 4 4 0 SHNi-TPR ATG16 PF08614.9 001261630.1_29626001_2 - 2.8 7.9 12.8 0.43 10.6 5.1 2.9 3 0 0 3 3 3 0 Autophagy protein 16 (ATG16) YlqD PF11068.6 001261630.1_29626001_2 - 3.3 8.0 8.8 6.1 7.1 8.8 1.4 1 0 0 1 1 1 0 YlqD protein NUDE_C PF04880.11 001261630.1_29626001_2 - 4.2 7.7 8.0 0.43 10.9 3.2 1.8 2 0 0 2 2 1 0 NUDE protein, C-terminal conserved region DUF4404 PF14357.4 001261630.1_29626001_2 - 9.4 6.9 8.2 11 6.7 0.2 3.2 3 1 0 3 3 2 0 Domain of unknown function (DUF4404) PMP22_Claudin PF00822.18 001257609.1_29623001_3 - 1.9e-51 174.1 13.5 3.1e-51 173.4 13.5 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001257609.1_29623001_3 - 3.4e-06 26.8 11.3 3.4e-06 26.8 11.3 2.2 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction L_HMGIC_fpl PF10242.7 001257609.1_29623001_3 - 0.00054 20.1 7.9 0.0011 19.0 7.9 1.5 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein DUF4064 PF13273.4 001257609.1_29623001_3 - 0.042 14.1 10.1 0.15 12.3 7.7 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) Connexin PF00029.17 001257609.1_29623001_3 - 0.064 12.9 7.0 0.14 11.8 1.7 2.3 2 0 0 2 2 2 0 Connexin DUF4834 PF16118.3 001257609.1_29623001_3 - 0.19 12.6 6.7 1.3 9.9 0.0 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4834) SPRY PF00622.26 001258151.1_29624001_2 - 8e-19 67.8 0.1 2.1e-18 66.4 0.1 1.7 2 0 0 2 2 2 1 SPRY domain SOCS_box PF07525.14 001258151.1_29624001_2 - 0.0022 18.1 1.4 0.0047 17.1 1.4 1.5 1 0 0 1 1 1 1 SOCS box 5_nucleotid PF05761.12 001261622.1_29624001_3 - 7.8e-60 202.9 0.0 1e-59 202.5 0.0 1.1 1 0 0 1 1 1 1 5' nucleotidase family Hydrolase_like PF13242.4 001261622.1_29624001_3 - 0.0036 17.2 0.0 0.0085 16.0 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like DUF4459 PF14673.4 001257541.1_29626001_2 - 0.082 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4459) Band_7 PF01145.23 001257541.1_29626001_3 - 5.3e-19 68.8 0.0 9.4e-19 68.0 0.0 1.4 1 0 0 1 1 1 1 SPFH domain / Band 7 family DUF4346 PF14251.4 001257541.1_29626001_3 - 0.29 11.1 1.8 0.5 10.3 1.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4346) Ig_3 PF13927.4 001267747.1_08022001_1 - 1e-12 48.3 0.1 4.8e-05 23.8 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001267747.1_08022001_1 - 5.7e-10 39.0 0.2 0.00088 19.2 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 001267747.1_08022001_1 - 6.2e-10 39.0 0.0 1.3e-05 25.1 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001267747.1_08022001_1 - 6.1e-09 35.7 0.1 1.4e-08 34.5 0.1 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain V-set PF07686.15 001267747.1_08022001_1 - 5.1e-08 32.9 0.2 3.4e-07 30.3 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.4 001267747.1_08022001_1 - 9.5e-08 32.2 0.0 0.012 15.8 0.1 2.5 2 1 0 2 2 2 2 Immunoglobulin domain C1-set PF07654.13 001267747.1_08022001_1 - 2.5e-05 24.5 0.3 0.0003 21.0 0.2 2.3 2 0 0 2 2 2 1 Immunoglobulin C1-set domain V-set_CD47 PF08204.9 001267747.1_08022001_1 - 0.021 14.7 0.3 0.045 13.6 0.0 1.7 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain Lep_receptor_Ig PF06328.9 001267747.1_08022001_1 - 0.06 13.2 0.3 8.8 6.3 0.0 2.4 2 0 0 2 2 2 0 Ig-like C2-type domain PP2C PF00481.19 001260605.1_29625001_3 - 1.9e-38 132.5 0.0 1.8e-36 126.0 0.0 2.3 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.4 001260605.1_29625001_3 - 0.11 12.0 0.0 0.22 11.0 0.0 1.6 1 1 0 1 1 1 0 Protein phosphatase 2C AstE_AspA PF04952.12 001285024.1_29523001_3 - 1e-70 238.0 0.0 1.2e-70 237.8 0.0 1.0 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family zf-H2C2_2 PF13465.4 001261793.2_29625001_3 - 8.3e-43 142.8 83.8 4.9e-10 39.2 2.4 10.6 11 0 0 11 11 11 7 Zinc-finger double domain zf-H2C2_5 PF13909.4 001261793.2_29625001_3 - 1.5e-35 120.4 60.1 3e-05 23.5 0.3 8.3 8 0 0 8 8 8 8 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 001261793.2_29625001_3 - 8.3e-20 69.9 94.4 0.0003 20.9 4.6 10.2 10 0 0 10 10 10 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001261793.2_29625001_3 - 0.0025 18.4 90.2 0.017 15.8 2.9 10.2 11 0 0 11 11 11 5 C2H2-type zinc finger zf-C2HE PF16278.3 001261793.2_29625001_3 - 0.052 13.9 41.2 1.1 9.6 1.2 7.1 2 2 5 7 7 7 0 C2HE / C2H2 / C2HC zinc-binding finger GAGA PF09237.9 001261793.2_29625001_3 - 0.63 9.8 26.4 0.11 12.2 0.8 5.7 2 2 2 5 5 5 0 GAGA factor DUF3505 PF12013.6 001261793.2_29625001_3 - 2.8 8.3 48.9 0.8 10.0 0.5 8.2 4 2 4 8 8 8 0 Protein of unknown function (DUF3505) FBA PF04300.11 001260876.1_29626001_1 - 1.1e-71 240.3 0.1 1.4e-71 239.9 0.1 1.1 1 0 0 1 1 1 1 F-box associated region F-box-like PF12937.5 001260876.1_29626001_1 - 3.4e-08 33.1 4.8 8.7e-08 31.8 4.8 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001260876.1_29626001_1 - 1.4e-07 31.0 4.1 3.4e-07 29.8 4.1 1.6 1 0 0 1 1 1 1 F-box domain Pkinase PF00069.23 001287417.1_49823001_2 - 5.8e-63 212.6 0.0 7e-63 212.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001287417.1_49823001_2 - 2.2e-38 131.9 0.0 4.8e-38 130.8 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001287417.1_49823001_2 - 7.3e-07 28.6 0.2 2.6e-05 23.6 0.0 2.7 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.12 001287417.1_49823001_2 - 1.5e-05 24.4 0.0 0.00027 20.2 0.0 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001287417.1_49823001_2 - 0.0029 17.4 0.0 0.005 16.7 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Opiods_neuropep PF01160.16 001261798.1_29622001_1 - 2.3e-17 62.7 5.9 4.6e-17 61.7 5.9 1.6 1 0 0 1 1 1 1 Vertebrate endogenous opioids neuropeptide Auxin_resp PF06507.11 001261798.1_29622001_2 - 0.44 10.7 1.8 0.9 9.7 0.3 2.0 2 0 0 2 2 2 0 Auxin response factor RNase_H PF00075.22 001285495.1_08023001_1 - 1.5e-44 151.5 0.0 2.2e-44 151.0 0.0 1.2 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.14 001285495.1_08023001_1 - 2.4e-19 69.2 1.2 4.4e-19 68.4 1.2 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin RVT_3 PF13456.4 001285495.1_08023001_1 - 0.0028 17.2 0.0 0.0058 16.2 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase-like Rdx PF10262.7 001278377.1_08022001_2 - 5.2e-08 32.8 0.1 1.6e-07 31.3 0.1 1.8 1 1 0 1 1 1 1 Rdx family Death PF00531.20 001267773.2_08023001_1 - 7.2e-19 67.6 0.1 1.7e-18 66.5 0.1 1.6 1 0 0 1 1 1 1 Death domain TNFR_c6 PF00020.16 001267773.2_08023001_1 - 2.7e-15 56.3 37.4 3.7e-09 36.7 8.6 3.4 3 0 0 3 3 3 3 TNFR/NGFR cysteine-rich region Ribosomal_L4 PF00573.20 001266200.1_29623001_3 - 2e-40 138.4 0.1 2e-40 138.4 0.1 1.9 2 0 0 2 2 2 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.4 001266200.1_29623001_3 - 9.9e-31 105.5 8.7 9.9e-31 105.5 8.7 2.1 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain NAD_binding_5 PF07994.10 001261319.1_29624001_1 - 2.5e-138 460.7 0.0 2.9e-138 460.5 0.0 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.15 001261319.1_29624001_1 - 5.2e-46 155.3 0.0 7.5e-46 154.7 0.0 1.3 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase CS PF04969.14 001283659.1_29524001_2 - 6.3e-09 36.6 0.0 9.5e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 CS domain Pkinase_C PF00433.22 001283659.1_29524001_2 - 1.5 9.4 5.3 4.3 8.0 5.3 1.8 1 0 0 1 1 1 0 Protein kinase C terminal domain WW PF00397.24 001261241.2_29623001_2 - 5.8e-15 54.8 17.3 6.2e-10 38.7 3.9 3.3 3 0 0 3 3 3 2 WW domain Insulin PF00049.16 001285579.1_09021001_1 - 4.9e-06 27.3 4.1 5.4e-05 24.0 4.1 2.0 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family Ins_beta PF03488.12 001285579.1_09021001_1 - 0.0049 16.7 2.1 0.35 10.8 0.2 2.2 2 0 0 2 2 2 2 Nematode insulin-related peptide beta type KRAB PF01352.25 001266019.1_29623001_2 - 8.1e-25 86.1 1.0 8.1e-25 86.1 1.0 1.7 2 0 0 2 2 2 1 KRAB box zf-C2H2 PF00096.24 001266019.1_29623001_2 - 0.0002 21.5 0.3 0.0002 21.5 0.3 2.2 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001266019.1_29623001_2 - 0.0067 17.0 0.3 0.0067 17.0 0.3 2.3 2 0 0 2 2 2 1 C2H2-type zinc finger zf-H2C2_2 PF13465.4 001266019.1_29623001_2 - 0.018 15.3 0.6 0.018 15.3 0.6 2.9 3 0 0 3 3 3 0 Zinc-finger double domain zf-met PF12874.5 001266019.1_29623001_2 - 0.019 15.2 0.3 0.067 13.5 0.3 2.0 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.4 001266019.1_29623001_3 - 3.7e-26 90.2 23.2 2.1e-09 37.2 0.3 5.2 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.24 001266019.1_29623001_3 - 1e-22 79.1 18.0 3.8e-07 30.1 0.3 4.8 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001266019.1_29623001_3 - 6.8e-13 48.1 22.1 0.0035 17.9 0.3 4.8 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001266019.1_29623001_3 - 8.1e-05 22.3 25.1 0.27 11.1 0.2 5.2 4 1 0 4 4 4 3 C2H2-type zinc finger C1_4 PF07975.10 001266019.1_29623001_3 - 0.0013 18.8 9.7 1.3 9.2 0.0 3.6 3 0 0 3 3 3 2 TFIIH C1-like domain Zn-ribbon_8 PF09723.8 001266019.1_29623001_3 - 0.0025 17.8 19.1 1.2 9.2 0.3 3.6 2 1 2 4 4 4 3 Zinc ribbon domain CpXC PF14353.4 001266019.1_29623001_3 - 0.034 14.0 8.8 10 6.1 0.1 3.8 3 1 0 3 3 3 0 CpXC protein zf-ribbon_3 PF13248.4 001266019.1_29623001_3 - 0.045 13.0 6.5 6.3 6.2 0.4 3.8 3 0 0 3 3 3 0 zinc-ribbon domain zf-C2H2_jaz PF12171.6 001266019.1_29623001_3 - 0.072 13.3 19.2 0.22 11.7 1.1 3.8 4 0 0 4 4 3 0 Zinc-finger double-stranded RNA-binding DZR PF12773.5 001266019.1_29623001_3 - 0.23 11.4 11.7 30 4.6 8.1 3.1 2 1 0 2 2 1 0 Double zinc ribbon zf-C2HC_2 PF13913.4 001266019.1_29623001_3 - 0.3 10.9 4.3 9 6.2 0.7 3.1 2 0 0 2 2 2 0 zinc-finger of a C2HC-type XPA_N PF01286.16 001266019.1_29623001_3 - 0.38 10.7 14.4 7.9 6.5 0.2 4.4 4 0 0 4 4 4 0 XPA protein N-terminal TFIIS_C PF01096.16 001266019.1_29623001_3 - 0.4 10.4 17.3 4.3 7.1 0.2 4.5 4 0 0 4 4 4 0 Transcription factor S-II (TFIIS) DNA_RNApol_7kD PF03604.11 001266019.1_29623001_3 - 0.63 9.6 15.1 4.3 7.0 0.6 4.3 4 0 0 4 4 4 0 DNA directed RNA polymerase, 7 kDa subunit zf-AN1 PF01428.14 001266019.1_29623001_3 - 0.67 10.0 14.0 9 6.4 0.2 4.4 4 0 0 4 4 4 0 AN1-like Zinc finger YhfH PF14149.4 001266019.1_29623001_3 - 0.81 9.6 15.0 2.8 7.9 0.2 4.2 4 0 0 4 4 4 0 YhfH-like protein Desulfoferrod_N PF06397.10 001266019.1_29623001_3 - 0.92 9.1 8.3 6.5 6.3 0.3 3.3 3 0 0 3 3 3 0 Desulfoferrodoxin, N-terminal domain zf-C2HE PF16278.3 001266019.1_29623001_3 - 1.5 9.2 18.5 2 8.8 0.5 4.3 1 1 1 2 2 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-LYAR PF08790.9 001266019.1_29623001_3 - 2.9 7.7 11.6 14 5.5 0.5 4.2 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger zinc_ribbon_4 PF13717.4 001266019.1_29623001_3 - 4.9 7.0 13.5 6.4 6.6 0.3 3.9 4 0 0 4 4 4 0 zinc-ribbon domain zf-C2H2_8 PF15909.3 001266019.1_29623001_3 - 5 7.3 15.3 0.33 11.2 1.6 3.0 3 1 1 4 4 2 0 C2H2-type zinc ribbon ADK_lid PF05191.12 001266019.1_29623001_3 - 8.5 6.4 9.6 23 5.0 1.1 3.6 2 1 1 3 3 3 0 Adenylate kinase, active site lid DBC1 PF14443.4 001270910.1_08028001_1 - 2.1e-40 137.4 0.0 4.2e-40 136.4 0.0 1.5 1 0 0 1 1 1 1 DBC1 S1-like PF14444.4 001270910.1_08028001_1 - 1.1e-26 92.5 0.2 2.5e-26 91.3 0.2 1.7 1 0 0 1 1 1 1 S1-like EKLF_TAD1 PF16832.3 001270910.1_08028001_1 - 0.0075 16.0 0.7 0.025 14.3 0.1 2.3 2 0 0 2 2 2 1 Erythroid krueppel-like transcription factor, transactivation 1 ADIP PF11559.6 001270910.1_08028001_1 - 0.046 13.7 7.3 0.095 12.6 7.3 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding KASH_CCD PF14662.4 001270910.1_08028001_1 - 0.08 12.6 11.9 0.14 11.8 11.9 1.3 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH TBPIP PF07106.11 001270910.1_08028001_1 - 0.3 10.7 2.8 0.55 9.9 2.8 1.3 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Snapin_Pallidin PF14712.4 001270910.1_08028001_1 - 0.3 11.4 8.6 0.69 10.3 8.6 1.5 1 0 0 1 1 1 0 Snapin/Pallidin DUF972 PF06156.11 001270910.1_08028001_1 - 0.57 10.7 5.3 1.5 9.4 5.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF972) BST2 PF16716.3 001270910.1_08028001_1 - 0.8 10.2 8.8 1.9 9.0 8.8 1.6 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 BLOC1_2 PF10046.7 001270910.1_08028001_1 - 0.82 9.9 4.5 1.5 9.1 4.5 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DASH_Hsk3 PF08227.9 001270910.1_08028001_1 - 0.91 9.8 6.7 5.2 7.4 1.4 2.7 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like MCU PF04678.11 001270910.1_08028001_1 - 1.1 9.3 4.1 2.7 8.0 4.1 1.6 1 0 0 1 1 1 0 Mitochondrial calcium uniporter APG6 PF04111.10 001270910.1_08028001_1 - 4 6.6 9.4 8 5.6 9.4 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 Spc7 PF08317.9 001270910.1_08028001_1 - 4.5 5.9 10.9 8.9 5.0 10.9 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein CybS PF05328.10 001285731.1_09023001_2 - 4.8e-23 81.2 0.3 6.7e-23 80.7 0.3 1.2 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit RWD PF05773.20 001266129.1_29623001_1 - 1.5e-15 57.4 0.0 2.7e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 RWD domain DUF1115 PF06544.10 001266129.1_29623001_1 - 0.00011 22.1 0.6 0.0075 16.2 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF1115) Mit_KHE1 PF10173.7 001260862.1_29625001_3 - 5.6 6.9 8.6 0.25 11.3 2.9 1.5 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related MITF_TFEB_C_3_N PF15951.3 001266320.1_29625001_2 - 1.5e-66 223.6 11.2 3e-66 222.6 11.2 1.5 1 0 0 1 1 1 1 MITF/TFEB/TFEC/TFE3 N-terminus DUF3371 PF11851.6 001266320.1_29625001_2 - 4.4e-35 121.3 6.4 4.4e-35 121.3 6.4 3.0 2 1 1 3 3 3 1 Domain of unknown function (DUF3371) HLH PF00010.24 001266320.1_29625001_2 - 2.9e-15 55.8 0.7 5.7e-15 54.9 0.7 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Ras PF00071.20 001261140.1_29624001_3 - 6.2e-38 129.8 0.0 7.9e-38 129.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001261140.1_29624001_3 - 9.6e-19 67.6 0.0 1.3e-18 67.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001261140.1_29624001_3 - 1.3e-06 27.8 0.0 1.9e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family ER_lumen_recept PF00810.16 001261069.1_29624001_3 - 8.7e-57 191.9 9.8 1.4e-56 191.3 9.8 1.3 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.12 001261069.1_29624001_3 - 4.7 6.9 13.9 1.1 9.0 0.3 3.3 4 0 0 4 4 4 0 PQ loop repeat Pou PF00157.15 001265584.1_08023001_1 - 2.6e-38 129.7 1.1 5.2e-38 128.8 1.1 1.5 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 001265584.1_08023001_1 - 4.9e-19 67.8 0.5 1.1e-18 66.7 0.5 1.6 1 0 0 1 1 1 1 Homeobox domain DUF521 PF04412.11 001265584.1_08023001_1 - 0.045 12.3 0.0 0.082 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF521) Homeobox_KN PF05920.9 001265584.1_08023001_1 - 0.22 11.3 0.5 0.47 10.3 0.0 1.8 2 0 0 2 2 2 0 Homeobox KN domain HIT PF01230.21 001266678.1_29622001_3 - 1.8e-27 95.8 0.0 2.7e-27 95.3 0.0 1.3 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.6 001266678.1_29622001_3 - 1.1e-21 77.3 0.0 1.4e-21 76.9 0.0 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Dickkopf_N PF04706.10 001260481.1_08024001_1 - 6.6e-16 58.4 16.3 6.6e-16 58.4 16.3 4.0 4 1 1 5 5 5 2 Dickkopf N-terminal cysteine-rich region LRR_9 PF14580.4 001260907.2_29623001_3 - 5e-95 315.8 1.6 7.5e-95 315.2 1.6 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.5 001260907.2_29623001_3 - 1.5e-06 28.2 9.1 0.0012 19.0 2.7 3.0 1 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001260907.2_29623001_3 - 1e-05 25.0 3.4 4.6e-05 23.0 2.4 2.3 1 1 1 2 2 2 2 Leucine rich repeat Histone_H2A_C PF16211.3 001261009.1_29623001_1 - 1.8e-12 46.6 0.5 2.9e-12 46.0 0.5 1.3 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.22 001261009.1_29623001_1 - 0.00019 21.7 0.0 0.00036 20.8 0.0 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Rad9 PF04139.11 001284976.1_29525001_2 - 7.7e-102 339.9 0.0 9.3e-102 339.6 0.0 1.1 1 0 0 1 1 1 1 Rad9 OLF PF02191.14 001265909.1_29624001_3 - 4.3e-86 288.4 1.2 5.5e-86 288.0 1.2 1.1 1 0 0 1 1 1 1 Olfactomedin-like domain Noelin-1 PF12308.6 001265909.1_29624001_3 - 3.5e-43 145.5 1.3 1.2e-41 140.6 0.2 2.7 3 0 0 3 3 3 1 Neurogenesis glycoprotein Helo_like_N PF17111.3 001265909.1_29624001_3 - 0.029 13.6 0.1 0.15 11.3 0.0 1.9 2 0 0 2 2 2 0 Fungal N-terminal domain of STAND proteins ABC_tran_CTD PF16326.3 001265909.1_29624001_3 - 0.13 12.4 2.5 3 8.0 0.1 2.7 1 1 2 3 3 3 0 ABC transporter C-terminal domain PCRF PF03462.16 001270912.1_08024001_3 - 2.6e-48 164.3 2.0 2.6e-48 164.3 2.0 1.6 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.18 001270912.1_08024001_3 - 9.6e-40 135.0 1.7 9.6e-40 135.0 1.7 2.9 2 1 1 3 3 2 1 RF-1 domain L27_1 PF09058.8 001270912.1_08024001_3 - 0.0059 16.5 4.3 0.0059 16.5 4.3 2.7 2 1 0 2 2 2 1 L27_1 Interferon PF00143.17 001270912.1_08024001_3 - 0.014 15.5 7.3 0.014 15.5 7.3 3.5 3 1 1 4 4 4 0 Interferon alpha/beta domain DUF2258 PF10015.7 001270912.1_08024001_3 - 0.051 13.6 1.3 1.2 9.2 0.2 2.7 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2258) DUF4635 PF15466.4 001270912.1_08024001_3 - 0.65 9.4 8.9 4.6 6.6 0.3 3.3 2 1 0 3 3 3 0 Domain of unknown function (DUF4635) DUF1910 PF08928.8 001270912.1_08024001_3 - 5.7 6.8 8.0 4.1 7.3 1.8 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF1910) SNN_linker PF09050.8 001270912.1_08024001_3 - 6.6 6.5 6.2 0.45 10.2 0.3 2.2 2 0 0 2 2 2 0 Stannin unstructured linker Fur_reg_FbpA PF13076.4 001270912.1_08024001_3 - 7.4 6.2 7.2 8.1 6.1 1.8 2.7 2 0 0 2 2 2 0 Fur-regulated basic protein A AAA_23 PF13476.4 001270912.1_08024001_3 - 8.1 6.8 14.5 0.75 10.1 7.3 2.4 3 0 0 3 3 3 0 AAA domain APG6 PF04111.10 001270912.1_08024001_3 - 9.2 5.4 21.6 0.2 10.9 14.8 1.6 2 0 0 2 2 2 0 Autophagy protein Apg6 Pkinase PF00069.23 001287413.1_49823001_1 - 7.6e-65 218.8 0.0 8.9e-65 218.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001287413.1_49823001_1 - 2.1e-37 128.7 0.0 2.9e-37 128.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001287413.1_49823001_1 - 2.9e-11 43.1 0.0 4.4e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 001287413.1_49823001_1 - 0.002 17.4 0.0 0.0033 16.7 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.7 001287413.1_49823001_1 - 0.0055 16.1 0.0 0.0079 15.6 0.0 1.2 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kelch_1 PF01344.23 001260743.1_29626001_2 - 3.9e-75 247.1 19.2 3.2e-14 52.1 0.1 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 001260743.1_29626001_2 - 6.1e-47 156.3 7.1 4.9e-09 36.0 0.0 6.3 1 1 5 6 6 6 6 Kelch motif BTB PF00651.29 001260743.1_29626001_2 - 6e-32 110.0 0.0 9.6e-32 109.4 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.13 001260743.1_29626001_2 - 2.1e-31 107.9 0.3 4.5e-31 106.9 0.3 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_3 PF13415.4 001260743.1_29626001_2 - 1.7e-25 88.5 4.3 4.3e-05 23.5 0.0 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.13 001260743.1_29626001_2 - 5.8e-25 86.1 8.1 6.1e-06 25.9 0.1 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.4 001260743.1_29626001_2 - 1.4e-24 85.7 1.5 4.4e-05 23.2 0.0 6.2 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.4 001260743.1_29626001_2 - 2.3e-08 33.7 10.0 0.00019 21.2 0.1 6.0 7 0 0 7 7 7 2 Kelch motif DUF3342 PF11822.6 001260743.1_29626001_2 - 0.0013 18.8 0.0 0.0033 17.4 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3342) Melittin PF01372.15 001260743.1_29626001_3 - 0.051 13.4 0.2 14 5.8 0.0 2.7 2 0 0 2 2 2 0 Melittin Mito_carr PF00153.25 001280682.1_39524001_2 - 7.6e-66 218.0 3.6 1.1e-24 86.1 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Pkinase_Tyr PF07714.15 001260870.1_29628001_3 - 3.4e-96 321.4 0.0 4.7e-96 320.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.17 001260870.1_29628001_3 - 3.9e-74 248.4 0.1 7.1e-74 247.6 0.1 1.5 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.23 001260870.1_29628001_3 - 2.5e-45 154.8 0.0 4.5e-45 153.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.19 001260870.1_29628001_3 - 8.6e-32 109.2 1.5 5.8e-15 55.3 0.2 3.0 3 0 0 3 3 2 2 Fibronectin type III domain EphA2_TM PF14575.4 001260870.1_29628001_3 - 1.8e-24 86.2 0.1 3.8e-24 85.2 0.1 1.6 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SAM_2 PF07647.15 001260870.1_29628001_3 - 2.2e-19 69.2 0.0 4.3e-19 68.2 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 001260870.1_29628001_3 - 2.2e-16 59.9 0.0 3.9e-16 59.1 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ephrin_rec_like PF07699.11 001260870.1_29628001_3 - 4.5e-05 23.0 5.7 4.5e-05 23.0 5.7 3.1 2 2 1 3 3 3 1 Putative ephrin-receptor like Pur_ac_phosph_N PF16656.3 001260870.1_29628001_3 - 0.00036 20.9 1.6 0.33 11.4 0.2 2.7 1 1 1 2 2 2 2 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.3 001260870.1_29628001_3 - 0.00055 19.9 0.3 0.64 10.1 0.0 3.1 3 0 0 3 3 3 1 Fibronectin type III domain SusE PF14292.4 001260870.1_29628001_3 - 0.0016 18.7 0.7 0.11 12.7 0.0 2.5 2 0 0 2 2 2 1 SusE outer membrane protein DUF2369 PF10179.7 001260870.1_29628001_3 - 0.069 13.5 0.2 0.33 11.3 0.2 2.0 1 1 0 1 1 1 0 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.8 001260870.1_29628001_3 - 0.082 13.1 0.2 4.7 7.4 0.0 3.5 4 0 0 4 4 4 0 Interferon-alpha/beta receptor, fibronectin type III Kdo PF06293.12 001260870.1_29628001_3 - 0.12 11.6 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2042 PF09743.7 001283489.1_29526001_1 - 2.2e-114 381.5 0.7 2.2e-114 381.5 0.7 1.9 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2042) IL31 PF15209.4 001283489.1_29526001_1 - 0.021 14.4 1.3 0.049 13.3 0.1 2.2 2 0 0 2 2 2 0 Interleukin 31 CBFD_NFYB_HMF PF00808.21 001283489.1_29526001_1 - 0.03 14.5 2.4 0.6 10.3 0.2 3.8 4 0 0 4 4 4 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Tn7_Tnp_TnsA_C PF08721.9 001283489.1_29526001_1 - 0.11 13.0 4.8 1 9.9 0.0 4.3 4 1 0 4 4 4 0 TnsA endonuclease C terminal Ras PF00071.20 001261682.1_29625001_1 - 4.9e-43 146.4 0.0 7.3e-43 145.8 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001261682.1_29625001_1 - 3.7e-19 69.0 0.0 6.1e-19 68.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001261682.1_29625001_1 - 2.8e-06 26.8 0.0 4.5e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SGIII PF15467.4 001260692.1_29627001_1 - 1.8e-217 722.8 33.3 2.2e-217 722.6 33.3 1.0 1 0 0 1 1 1 1 Secretogranin-3 DUF2680 PF10925.6 001260692.1_29627001_1 - 1.3e-05 24.9 5.5 0.99 9.3 0.1 4.0 4 0 0 4 4 4 3 Protein of unknown function (DUF2680) DUF1974 PF09317.9 001260692.1_29627001_1 - 0.0026 17.3 3.5 0.095 12.1 1.0 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF1974) HMG_box PF00505.17 001261489.2_29625001_1 - 1.4e-17 63.7 0.4 3.3e-17 62.5 0.4 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 001261489.2_29625001_1 - 1.5e-11 44.6 0.6 2.8e-11 43.7 0.6 1.4 1 0 0 1 1 1 1 HMG-box domain YABBY PF04690.11 001261489.2_29625001_1 - 0.034 14.6 0.1 0.074 13.5 0.1 1.6 1 0 0 1 1 1 0 YABBY protein Ras PF00071.20 001266164.1_29624001_2 - 2.4e-65 218.9 1.1 3e-65 218.6 1.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001266164.1_29624001_2 - 1.2e-35 122.2 0.1 2e-35 121.5 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001266164.1_29624001_2 - 5.8e-16 58.3 0.1 8.4e-16 57.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001266164.1_29624001_2 - 4.9e-05 22.7 0.1 7.5e-05 22.1 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit DUF258 PF03193.14 001266164.1_29624001_2 - 5.6e-05 23.0 0.4 0.33 10.7 0.1 2.2 1 1 1 2 2 2 2 Protein of unknown function, DUF258 Gtr1_RagA PF04670.10 001266164.1_29624001_2 - 6.8e-05 22.2 0.0 9.2e-05 21.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001266164.1_29624001_2 - 8.9e-05 22.4 0.0 0.00018 21.4 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001266164.1_29624001_2 - 0.00033 20.1 0.0 0.00058 19.3 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA PF00004.27 001266164.1_29624001_2 - 0.028 14.7 0.0 0.75 10.1 0.0 2.2 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) FeoB_N PF02421.16 001266164.1_29624001_2 - 0.085 12.2 0.1 0.27 10.6 0.1 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_16 PF13191.4 001266164.1_29624001_2 - 0.088 13.0 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain MHC_II_alpha PF00993.18 001284834.1_29523001_2 - 8e-32 108.7 0.0 1.1e-31 108.2 0.0 1.2 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001284834.1_29523001_2 - 2.2e-28 97.3 0.5 4.1e-28 96.4 0.5 1.5 1 0 0 1 1 1 1 C1-set C-terminal domain C1-set PF07654.13 001284834.1_29523001_2 - 8.3e-25 86.9 0.0 1.4e-24 86.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain C2-set_2 PF08205.10 001284834.1_29523001_2 - 9.9e-05 22.2 0.0 0.00017 21.4 0.0 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 001284834.1_29523001_2 - 0.00025 21.5 0.0 0.0004 20.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Marek_A PF02124.13 001284834.1_29523001_2 - 0.00039 20.2 0.0 0.00054 19.7 0.0 1.1 1 0 0 1 1 1 1 Marek's disease glycoprotein A SKG6 PF08693.8 001284834.1_29523001_2 - 0.23 10.8 1.7 0.46 9.8 1.7 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Myotub-related PF06602.12 001261718.1_29627001_3 - 8.9e-147 488.4 0.2 1.3e-146 487.8 0.2 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.18 001261718.1_29627001_3 - 7.8e-20 70.7 0.0 1.5e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 GRAM domain DSPc PF00782.18 001261718.1_29627001_3 - 0.0004 20.1 0.0 0.00093 18.9 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 001261718.1_29627001_3 - 0.00063 19.2 0.0 0.0013 18.2 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase 3-PAP PF12578.6 001261718.1_29627001_3 - 0.0008 19.0 0.2 0.0016 18.1 0.2 1.4 1 0 0 1 1 1 1 Myotubularin-associated protein Y_phosphatase3 PF13350.4 001261718.1_29627001_3 - 0.055 13.3 0.0 0.094 12.5 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Ribosomal_L24e PF01246.18 001265968.1_29622001_3 - 7e-34 115.7 0.7 7e-34 115.7 0.7 1.7 2 0 0 2 2 2 1 Ribosomal protein L24e SOAR PF16533.3 001261535.1_29629001_2 - 2.3e-43 146.1 2.5 2.3e-43 146.1 2.5 3.1 2 1 0 2 2 2 1 STIM1 Orai1-activating region SAM_2 PF07647.15 001261535.1_29629001_2 - 1.1e-06 28.5 0.3 2.6e-06 27.3 0.0 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 001261535.1_29629001_2 - 0.00026 21.2 0.1 0.00064 20.0 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) AAA_11 PF13086.4 001261535.1_29629001_2 - 0.067 12.8 3.7 0.12 11.9 3.7 1.5 1 0 0 1 1 1 0 AAA domain Prominin PF05478.9 001261535.1_29629001_2 - 0.37 8.6 8.0 0.54 8.0 8.0 1.1 1 0 0 1 1 1 0 Prominin AAA_23 PF13476.4 001261535.1_29629001_2 - 2.5 8.4 16.2 1.4 9.2 9.8 3.0 2 1 0 2 2 2 0 AAA domain APG6 PF04111.10 001261535.1_29629001_2 - 3 7.0 21.8 4.9 6.3 21.8 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4446 PF14584.4 001261535.1_29629001_2 - 4.2 7.2 6.6 0.41 10.5 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) TMPIT PF07851.11 001261535.1_29629001_2 - 6.4 5.8 11.7 11 5.0 11.7 1.4 1 0 0 1 1 1 0 TMPIT-like protein CREPT PF16566.3 001261686.1_29628001_3 - 8.6e-62 207.5 5.9 1.7e-61 206.6 5.9 1.5 1 0 0 1 1 1 1 Cell-cycle alteration and expression-elevated protein in tumour CTD_bind PF04818.11 001261686.1_29628001_3 - 1.8e-21 76.6 0.4 5e-21 75.2 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase II-binding domain. CTK3 PF12243.6 001261686.1_29628001_3 - 0.029 14.2 0.0 0.052 13.4 0.0 1.4 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 S_100 PF01023.17 001257530.1_29622001_1 - 5.2e-19 67.6 0.2 1e-18 66.6 0.2 1.5 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.30 001257530.1_29622001_1 - 5.1e-07 28.7 1.1 3.5e-06 26.0 0.2 2.2 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.4 001257530.1_29622001_1 - 4.1e-06 27.1 0.0 5.9e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 001257530.1_29622001_1 - 7e-05 22.3 0.8 0.016 15.0 0.2 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.4 001257530.1_29622001_1 - 0.00036 19.8 2.0 0.00083 18.6 0.4 2.2 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.4 001257530.1_29622001_1 - 0.0007 19.2 2.6 0.0047 16.5 1.3 2.6 2 1 0 2 2 2 1 EF-hand domain pair SPARC_Ca_bdg PF10591.7 001257530.1_29622001_1 - 0.097 12.9 0.1 0.44 10.7 0.0 1.8 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.9 001257530.1_29622001_1 - 0.098 13.4 0.0 0.15 12.8 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain MCM PF00493.21 001260615.1_29626001_1 - 3.7e-138 460.0 0.7 4.6e-138 459.7 0.1 1.4 2 0 0 2 2 2 1 MCM2/3/5 family MCM_OB PF17207.1 001260615.1_29626001_1 - 3.7e-34 117.2 0.4 6.9e-34 116.3 0.4 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_N PF14551.4 001260615.1_29626001_1 - 4.4e-16 59.2 2.1 1.3e-15 57.7 2.1 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.19 001260615.1_29626001_1 - 6.8e-08 32.0 0.0 1.8e-07 30.6 0.0 1.7 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.9 001260615.1_29626001_1 - 6.6e-05 22.6 0.0 0.00016 21.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.12 001260615.1_29626001_1 - 0.0014 18.5 0.0 0.0033 17.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.24 001260615.1_29626001_1 - 0.0042 16.7 0.0 0.015 14.9 0.0 1.8 2 0 0 2 2 2 1 Sigma-54 interaction domain Jnk-SapK_ap_N PF09744.7 001260615.1_29626001_1 - 1.3 9.0 7.5 0.84 9.7 0.3 2.4 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 7tm_1 PF00001.19 001261729.1_29624001_2 - 2.6e-45 154.6 31.0 9.5e-45 152.8 31.0 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) IL13 PF03487.11 001267754.1_08023001_3 - 3.3e-67 224.1 0.0 4.5e-67 223.7 0.0 1.2 1 0 0 1 1 1 1 Interleukin-13 Methyltransf_25 PF13649.4 001257521.1_29624001_2 - 4.1e-09 36.9 0.0 6.8e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.11 001257521.1_29624001_2 - 3.6e-08 33.0 0.0 5.2e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.10 001257521.1_29624001_2 - 1.3e-06 28.8 0.0 2.7e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.9 001257521.1_29624001_2 - 9e-06 24.7 0.0 1.5e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PRMT5 PF05185.14 001257521.1_29624001_2 - 9.8e-06 24.7 0.0 1.9e-05 23.8 0.0 1.3 1 1 0 1 1 1 1 PRMT5 arginine-N-methyltransferase MTS PF05175.12 001257521.1_29624001_2 - 0.00015 21.2 0.0 0.00026 20.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Met_10 PF02475.14 001257521.1_29624001_2 - 0.00023 20.8 0.0 0.00035 20.3 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_23 PF13489.4 001257521.1_29624001_2 - 0.00044 20.1 0.0 0.0008 19.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.5 001257521.1_29624001_2 - 0.0005 19.9 0.0 0.00085 19.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 001257521.1_29624001_2 - 0.0011 18.6 0.0 0.002 17.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.18 001257521.1_29624001_2 - 0.0012 18.1 0.0 0.0018 17.5 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.10 001257521.1_29624001_2 - 0.042 14.4 0.0 0.068 13.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.4 001257521.1_29624001_2 - 0.044 14.7 0.0 0.076 13.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.13 001257521.1_29624001_2 - 0.048 13.2 0.1 0.08 12.4 0.1 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Motile_Sperm PF00635.24 001261620.1_29624001_1 - 1.7e-17 63.1 0.1 3.1e-17 62.3 0.1 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain DUF3029 PF11230.6 001261620.1_29624001_1 - 0.071 11.3 0.0 0.098 10.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3029) DSPc PF00782.18 001266125.1_29624001_1 - 1.4e-05 24.8 0.0 3.2e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 001266125.1_29624001_1 - 5e-05 22.8 0.0 7.9e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PRIMA1 PF16101.3 001266125.1_29624001_3 - 2 8.3 6.6 3.9 7.4 6.6 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CAP_N PF01213.17 001266125.1_29624001_3 - 8.3 5.6 9.0 12 5.2 9.0 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Stathmin PF00836.17 001283307.1_29522001_2 - 7.3e-57 191.0 24.2 1.1e-56 190.4 24.2 1.3 1 0 0 1 1 1 1 Stathmin family CCDC84 PF14968.4 001283307.1_29522001_2 - 0.014 14.9 1.6 0.015 14.8 1.6 1.1 1 0 0 1 1 1 0 Coiled coil protein 84 Exonuc_VII_L PF02601.13 001283307.1_29522001_2 - 0.13 11.7 4.8 0.14 11.5 4.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit PAT1 PF09770.7 001283307.1_29522001_2 - 0.17 10.0 7.9 0.19 9.8 7.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SCNM1_acidic PF15805.3 001257712.2_29622001_1 - 1.1e-25 88.9 0.6 2.4e-25 87.8 0.6 1.5 1 0 0 1 1 1 1 Acidic C-terminal region of sodium channel modifier 1 SCNM1 zf-SCNM1 PF15803.3 001257712.2_29622001_1 - 1.8e-15 56.1 1.5 3.8e-15 55.1 1.5 1.6 1 0 0 1 1 1 1 Zinc-finger of sodium channel modifier 1 Synuclein PF01387.15 001266560.1_29622001_1 - 9.3e-55 184.3 22.5 1.1e-54 184.1 22.5 1.1 1 0 0 1 1 1 1 Synuclein Mononeg_mRNAcap PF14318.4 001266560.1_29622001_1 - 0.084 12.0 0.6 0.12 11.5 0.6 1.1 1 0 0 1 1 1 0 Mononegavirales mRNA-capping region V eIF-1a PF01176.17 001267764.1_08022001_1 - 1.9e-21 75.5 0.1 2.6e-21 75.0 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 DUF4604 PF15377.4 001266705.1_29622001_3 - 2.8e-27 96.1 10.5 4.2e-27 95.6 10.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) Opiods_neuropep PF01160.16 001280677.1_39522001_1 - 3.3e-17 62.1 7.7 5.3e-17 61.5 7.7 1.3 1 0 0 1 1 1 1 Vertebrate endogenous opioids neuropeptide DUF3649 PF12365.6 001280677.1_39522001_1 - 0.69 9.5 5.4 1.3 8.7 5.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3649) Pex14_N PF04695.11 001285002.1_29524001_1 - 4.4e-21 76.1 1.8 4.4e-21 76.1 1.8 3.6 3 2 0 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region HemX PF04375.12 001285002.1_29524001_1 - 0.002 17.4 2.7 0.0036 16.5 2.7 1.3 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase BUD22 PF09073.8 001285002.1_29524001_1 - 0.0024 17.1 0.1 0.0035 16.6 0.1 1.2 1 0 0 1 1 1 1 BUD22 DUF948 PF06103.9 001285002.1_29524001_1 - 0.014 15.5 0.2 0.028 14.5 0.2 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Spc7 PF08317.9 001285002.1_29524001_1 - 0.04 12.6 4.6 0.072 11.8 4.6 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein CENP-H PF05837.10 001285002.1_29524001_1 - 0.36 11.1 5.1 0.87 9.9 5.1 1.6 1 0 0 1 1 1 0 Centromere protein H (CENP-H) TolA_bind_tri PF16331.3 001285002.1_29524001_1 - 0.44 10.5 8.9 1.9 8.5 6.0 2.5 1 1 0 2 2 2 0 TolA binding protein trimerisation Fib_alpha PF08702.8 001285002.1_29524001_1 - 0.89 9.6 3.3 1.5 8.8 3.3 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Peptidase_M16 PF00675.18 001284531.1_29525001_3 - 1.5e-32 112.5 0.0 2.5e-32 111.8 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.19 001284531.1_29525001_3 - 1.1e-20 74.2 0.1 1.9e-20 73.5 0.1 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain DUF1471 PF07338.11 001284531.1_29525001_3 - 0.06 13.2 0.1 0.36 10.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1471) Abhydrolase_1 PF00561.18 001260942.1_29625001_1 - 3.2e-17 62.9 0.1 2.8e-15 56.5 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001260942.1_29625001_1 - 6.4e-10 39.9 0.1 6.4e-10 39.9 0.1 1.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF1057 PF06342.10 001260942.1_29625001_1 - 1.8e-05 23.8 0.0 2.7e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Hydrolase_4 PF12146.6 001260942.1_29625001_1 - 0.00026 20.2 0.0 0.0036 16.5 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 REV PF00424.16 001260942.1_29625001_1 - 0.016 15.0 0.0 0.28 11.1 0.0 2.2 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) IQ PF00612.25 001283765.1_29524001_3 - 1.4e-05 24.3 0.3 4.6e-05 22.7 0.3 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif BssS PF13991.4 001283765.1_29524001_3 - 0.089 12.7 0.0 0.28 11.2 0.0 1.8 1 0 0 1 1 1 0 BssS protein family RNase_H PF00075.22 001285492.1_08024001_1 - 7.3e-42 142.8 0.0 1.1e-41 142.3 0.0 1.2 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.14 001285492.1_08024001_1 - 2.4e-19 69.2 1.2 4.4e-19 68.4 1.2 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin RVT_3 PF13456.4 001285492.1_08024001_1 - 0.01 15.4 0.0 0.023 14.2 0.0 1.6 2 0 0 2 2 2 0 Reverse transcriptase-like TNF PF00229.16 001278383.1_08022001_2 - 5.1e-16 58.7 0.0 7.6e-16 58.1 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1q PF00386.19 001278383.1_08022001_2 - 0.0049 17.0 0.0 0.0073 16.4 0.0 1.2 1 0 0 1 1 1 1 C1q domain Integrin_beta PF00362.16 001265993.1_29629001_2 - 6.8e-104 346.8 0.0 1.2e-103 346.0 0.0 1.4 1 0 0 1 1 1 1 Integrin beta chain VWA domain PSI_integrin PF17205.1 001265993.1_29629001_2 - 2.3e-11 43.2 5.1 2.3e-11 43.2 5.1 4.8 5 0 0 5 5 5 1 Integrin plexin domain EGF_2 PF07974.11 001265993.1_29629001_2 - 7e-10 39.0 67.9 7.1e-05 23.0 13.4 5.5 4 0 0 4 4 4 3 EGF-like domain FGGY_N PF00370.19 001261112.1_29624001_3 - 3.4e-47 160.9 0.1 6.1e-46 156.8 0.1 2.1 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.14 001261112.1_29624001_3 - 3.5e-34 118.1 0.0 6.8e-34 117.2 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain 3D PF06725.9 001261112.1_29624001_3 - 0.12 12.5 0.0 1.3 9.1 0.0 2.4 2 0 0 2 2 2 0 3D domain COesterase PF00135.26 001278449.1_29629001_2 - 6.9e-191 635.5 0.0 8.2e-191 635.2 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 001278449.1_29629001_2 - 4.9e-06 26.4 0.2 2.4e-05 24.1 0.2 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 001278449.1_29629001_2 - 0.048 13.0 0.0 0.08 12.3 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family Ras PF00071.20 001266171.1_29624001_2 - 1.1e-61 207.0 0.3 1.4e-61 206.7 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001266171.1_29624001_2 - 7.1e-35 119.7 0.0 1.1e-34 119.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001266171.1_29624001_2 - 8e-12 44.8 0.0 1.1e-11 44.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001266171.1_29624001_2 - 0.00021 20.6 0.0 0.00028 20.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001266171.1_29624001_2 - 0.0005 20.0 0.0 0.00075 19.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001266171.1_29624001_2 - 0.0057 16.5 0.7 1.1 9.0 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001266171.1_29624001_2 - 0.01 15.2 0.0 0.018 14.5 0.0 1.4 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.4 001266171.1_29624001_2 - 0.09 13.0 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Ada3 PF10198.7 001266137.1_29624001_3 - 6e-27 94.2 11.2 1.3e-25 89.9 11.3 2.5 2 0 0 2 2 2 1 Histone acetyltransferases subunit 3 YkyA PF10368.7 001266137.1_29624001_3 - 2 8.0 7.9 8.3 6.0 6.0 2.3 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein HSP70 PF00012.18 001266596.1_29626001_2 - 1.4e-271 901.9 9.3 1.6e-271 901.7 9.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 001266596.1_29626001_2 - 1.2e-17 63.6 0.9 1.7e-16 59.9 0.3 2.3 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.4 001266596.1_29626001_2 - 0.00013 22.2 5.7 0.32 11.3 0.1 4.3 4 1 0 4 4 4 2 Cell division protein FtsA DUF4624 PF15417.4 001266596.1_29626001_2 - 0.0013 18.4 0.1 0.31 10.7 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4624) Hydantoinase_A PF01968.16 001266596.1_29626001_2 - 0.0056 15.9 1.9 0.018 14.2 0.1 2.6 2 1 1 3 3 3 1 Hydantoinase/oxoprolinase DDR PF08841.8 001266596.1_29626001_2 - 0.01 14.7 0.8 0.028 13.3 0.4 1.7 1 1 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain FGGY_C PF02782.14 001266596.1_29626001_2 - 0.047 13.3 0.0 0.099 12.2 0.0 1.5 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain DUF4795 PF16043.3 001266596.1_29626001_2 - 0.52 9.7 10.1 0.084 12.3 3.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) Radial_spoke_3 PF06098.9 001266596.1_29626001_2 - 9.6 5.3 13.4 0.19 10.8 6.3 1.6 2 0 0 2 2 2 0 Radial spoke protein 3 IIGP PF05049.11 001135115.1_32926001_2 - 3.5e-148 493.5 1.6 4.3e-148 493.2 1.6 1.1 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) MMR_HSR1 PF01926.21 001135115.1_32926001_2 - 1.1e-09 38.3 0.0 2e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.21 001135115.1_32926001_2 - 1.6e-07 31.4 0.0 0.019 14.9 0.1 2.4 1 1 1 2 2 2 2 Dynamin family DUF258 PF03193.14 001135115.1_32926001_2 - 0.00066 19.5 0.1 0.0013 18.5 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 ABC_tran PF00005.25 001135115.1_32926001_2 - 0.00085 19.7 0.0 0.0017 18.7 0.0 1.5 1 0 0 1 1 1 1 ABC transporter FtsK_SpoIIIE PF01580.16 001135115.1_32926001_2 - 0.0016 17.7 0.0 0.003 16.8 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_29 PF13555.4 001135115.1_32926001_2 - 0.0019 17.8 0.1 0.0038 16.8 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain FeoB_N PF02421.16 001135115.1_32926001_2 - 0.0029 17.0 0.0 0.0049 16.3 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B AIG1 PF04548.14 001135115.1_32926001_2 - 0.0029 16.8 0.0 0.0049 16.1 0.0 1.3 1 0 0 1 1 1 1 AIG1 family Zeta_toxin PF06414.10 001135115.1_32926001_2 - 0.012 14.8 0.0 0.025 13.7 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin T2SSE PF00437.18 001135115.1_32926001_2 - 0.016 14.2 0.0 0.029 13.3 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Roc PF08477.11 001135115.1_32926001_2 - 0.016 15.3 0.0 0.037 14.1 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase KAP_NTPase PF07693.12 001135115.1_32926001_2 - 0.024 13.8 0.0 0.045 12.9 0.0 1.4 1 1 0 1 1 1 0 KAP family P-loop domain AAA_22 PF13401.4 001135115.1_32926001_2 - 0.032 14.4 0.0 0.064 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Septin PF00735.16 001135115.1_32926001_2 - 0.044 12.9 0.0 0.071 12.2 0.0 1.3 1 0 0 1 1 1 0 Septin AAA_16 PF13191.4 001135115.1_32926001_2 - 0.051 13.8 0.1 0.19 11.9 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Sigma54_activat PF00158.24 001135115.1_32926001_2 - 0.082 12.5 0.1 0.16 11.5 0.1 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_23 PF13476.4 001135115.1_32926001_2 - 1.3 9.4 9.9 0.87 9.9 7.3 2.1 1 1 1 2 2 2 0 AAA domain HSP70 PF00012.18 001285703.1_09024001_1 - 1.4e-258 858.9 4.3 1.6e-258 858.7 4.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 001285703.1_09024001_1 - 2.1e-16 59.5 0.1 1.5e-15 56.7 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.14 001285703.1_09024001_1 - 0.01 15.4 0.0 0.021 14.4 0.0 1.5 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.8 001285703.1_09024001_1 - 0.066 12.1 0.5 0.21 10.4 0.3 1.8 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Pox_D5 PF03288.14 001285703.1_09024001_1 - 0.094 13.1 0.2 0.31 11.5 0.1 1.9 2 0 0 2 2 2 0 Poxvirus D5 protein-like Radial_spoke_3 PF06098.9 001285703.1_09024001_1 - 5.2 6.1 10.9 0.13 11.4 4.4 1.5 2 0 0 2 2 2 0 Radial spoke protein 3 RMI1_N PF08585.10 001258092.1_29625001_2 - 1e-53 182.2 0.1 2e-53 181.2 0.1 1.5 1 0 0 1 1 1 1 RecQ mediated genome instability protein RMI1_C PF16099.3 001258092.1_29625001_2 - 1.8e-44 150.9 0.1 3.3e-44 150.0 0.1 1.5 1 0 0 1 1 1 1 Recq-mediated genome instability protein 1, C-terminal OB-fold FKBP_C PF00254.26 001266094.1_29622001_1 - 3.8e-28 97.5 0.0 6.8e-28 96.7 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_7 PF13499.4 001266094.1_29622001_1 - 1.6e-08 34.8 3.1 2.9e-08 33.9 3.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 001266094.1_29622001_1 - 8e-07 28.4 3.7 0.013 15.3 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.30 001266094.1_29622001_1 - 2e-05 23.7 6.3 0.0055 16.0 1.8 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.4 001266094.1_29622001_1 - 4.7e-05 22.6 3.6 0.022 14.1 1.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.4 001266094.1_29622001_1 - 0.073 12.7 3.2 6.4 6.5 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain pair ODC_AZ PF02100.15 001289928.1_08024001_2 - 2e-19 69.6 0.0 3.8e-19 68.7 0.0 1.4 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Synaptobrevin PF00957.19 001261331.1_29626001_2 - 3.6e-32 109.9 2.4 5.4e-32 109.3 2.4 1.3 1 0 0 1 1 1 1 Synaptobrevin MCU PF04678.11 001261331.1_29626001_2 - 0.069 13.2 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DUF912 PF06024.10 001261331.1_29626001_2 - 0.11 12.7 0.1 0.18 12.0 0.1 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) MgtE PF01769.14 001261331.1_29626001_2 - 0.85 9.9 5.5 0.1 12.8 0.7 1.8 2 0 0 2 2 2 0 Divalent cation transporter SNARE PF05739.17 001261331.1_29626001_2 - 0.89 9.5 5.2 2.1 8.3 5.2 1.6 1 0 0 1 1 1 0 SNARE domain Rdx PF10262.7 001199908.2_08022001_2 - 4e-08 33.2 0.1 1.5e-07 31.4 0.1 1.9 1 1 0 1 1 1 1 Rdx family adh_short PF00106.23 001257943.1_29624001_2 - 1.3e-58 197.5 0.1 1.8e-58 197.1 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001257943.1_29624001_2 - 1.7e-29 102.9 0.0 2.4e-29 102.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001257943.1_29624001_2 - 5.7e-14 52.3 0.2 8.4e-14 51.7 0.2 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.4 001257943.1_29624001_2 - 0.0026 17.6 0.0 0.0049 16.7 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.13 001257943.1_29624001_2 - 0.0049 15.9 0.3 0.0071 15.4 0.3 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein THF_DHG_CYH_C PF02882.17 001257943.1_29624001_2 - 0.097 11.9 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain SERTA PF06031.11 001261684.1_29624001_3 - 6.4e-17 60.8 0.8 1.2e-16 59.9 0.8 1.5 1 0 0 1 1 1 1 SERTA motif S36_mt PF10937.6 001261684.1_29624001_3 - 5.3 8.5 5.8 32 6.0 5.8 2.3 1 1 0 1 1 1 0 Ribosomal protein S36, mitochondrial LSM PF01423.20 001257958.1_29622001_2 - 3e-11 42.7 0.2 4.2e-11 42.2 0.2 1.2 1 0 0 1 1 1 1 LSM domain APOBEC_N PF08210.9 001267742.1_08023001_1 - 5.5e-81 270.6 8.1 3.4e-44 150.8 0.3 2.0 2 0 0 2 2 2 2 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001267742.1_08023001_1 - 3.5e-60 199.8 0.2 3.1e-29 100.6 0.0 2.6 2 0 0 2 2 2 2 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 001267742.1_08023001_1 - 0.0024 17.6 0.0 2.9 7.7 0.0 2.3 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region Pox_E10 PF04805.10 001267742.1_08023001_1 - 0.017 14.9 0.6 2.5 7.9 0.0 2.6 2 0 0 2 2 2 0 E10-like protein conserved region Pox_A3L PF05288.9 001267742.1_08023001_1 - 0.089 12.7 0.1 2.2 8.2 0.0 2.5 2 0 0 2 2 2 0 Poxvirus A3L Protein DUF2162 PF09930.7 001267742.1_08023001_1 - 5.6 6.2 7.4 0.21 10.8 0.3 1.9 2 0 0 2 2 2 0 Predicted transporter (DUF2162) XRCC1_N PF01834.14 001260945.1_29623001_1 - 0.04 13.9 0.0 0.07 13.1 0.0 1.3 1 0 0 1 1 1 0 XRCC1 N terminal domain Cadherin PF00028.15 001258186.1_29629001_3 - 1.5e-100 329.7 11.4 3.2e-20 72.2 0.1 7.4 7 0 0 7 7 7 7 Cadherin domain Protocadherin PF08374.9 001258186.1_29629001_3 - 1.5e-82 276.7 1.0 1.5e-82 276.7 1.0 1.8 2 0 0 2 2 2 1 Protocadherin Cadherin_2 PF08266.10 001258186.1_29629001_3 - 2e-18 65.8 0.0 3.1e-08 33.2 0.0 5.8 6 0 0 6 6 6 4 Cadherin-like Cadherin_3 PF16184.3 001258186.1_29629001_3 - 5e-07 29.6 16.7 0.24 11.3 0.1 5.9 6 0 0 6 6 6 4 Cadherin-like He_PIG PF05345.10 001258186.1_29629001_3 - 0.0018 18.3 4.3 1.8 8.7 0.0 5.0 4 0 0 4 4 4 1 Putative Ig domain EphA2_TM PF14575.4 001258186.1_29629001_3 - 0.0088 16.7 0.3 0.026 15.2 0.3 1.8 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain DUF1510 PF07423.9 001258186.1_29629001_3 - 0.037 13.3 0.2 0.075 12.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) AP3D1 PF06375.9 001258186.1_29629001_3 - 0.51 10.5 8.3 0.12 12.5 0.4 2.6 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 DUF4834 PF16118.3 001258186.1_29629001_3 - 0.8 10.6 3.2 0.41 11.5 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) MOEP19 PF16005.3 001287467.1_39522001_2 - 2.4e-35 120.3 0.2 3.2e-35 119.9 0.2 1.2 1 0 0 1 1 1 1 KH-like RNA-binding domain Arm PF00514.21 001266516.1_29629001_3 - 3.5e-32 109.3 5.6 9.8e-08 31.6 0.0 7.2 7 0 0 7 7 7 5 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.4 001266516.1_29629001_3 - 2.2e-05 24.7 0.5 8.4 6.8 0.0 4.9 5 0 0 5 5 5 2 HEAT-like repeat HEAT_2 PF13646.4 001266516.1_29629001_3 - 0.0038 17.4 2.2 2.1 8.6 0.1 3.1 3 0 0 3 3 3 2 HEAT repeats Cnd1 PF12717.5 001266516.1_29629001_3 - 0.016 15.1 1.7 0.07 13.0 0.1 2.8 4 0 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.20 001266516.1_29629001_3 - 0.11 12.7 1.4 1e+02 3.4 0.0 4.1 4 0 0 4 4 4 0 HEAT repeat Ebp2 PF05890.10 001266516.1_29629001_3 - 0.11 11.8 2.0 0.25 10.7 2.0 1.5 1 0 0 1 1 1 0 Eukaryotic rRNA processing protein EBP2 Atx10homo_assoc PF09759.7 001266516.1_29629001_3 - 0.44 10.5 2.5 1.7 8.6 0.0 2.9 4 0 0 4 4 4 0 Spinocerebellar ataxia type 10 protein domain Ribosomal_S19 PF00203.19 001265922.1_29622001_1 - 2.1e-40 136.3 0.4 3e-40 135.8 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Prok_Ub PF14454.4 001265922.1_29622001_1 - 0.026 14.0 0.1 0.063 12.8 0.1 1.6 1 0 0 1 1 1 0 Prokaryotic Ubiquitin MAP65_ASE1 PF03999.10 001265922.1_29622001_1 - 0.04 12.5 1.0 0.049 12.2 1.0 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) HLH PF00010.24 001261369.2_29623001_2 - 7.8e-18 64.1 0.7 1.3e-17 63.3 0.7 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain IncA PF04156.12 001261369.2_29623001_2 - 0.0076 15.9 4.7 0.011 15.4 4.7 1.2 1 0 0 1 1 1 1 IncA protein bZIP_2 PF07716.13 001261369.2_29623001_2 - 0.019 14.9 2.6 0.054 13.5 2.6 1.8 1 0 0 1 1 1 0 Basic region leucine zipper SlyX PF04102.10 001261369.2_29623001_2 - 0.047 14.2 4.7 0.072 13.6 3.9 1.7 1 1 0 1 1 1 0 SlyX Filament PF00038.19 001261369.2_29623001_2 - 0.071 12.5 6.6 0.089 12.2 6.6 1.1 1 0 0 1 1 1 0 Intermediate filament protein DUF2452 PF10504.7 001266364.1_29622001_1 - 1e-73 245.8 0.0 1.4e-73 245.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2452) Ribosomal_S4e PF00900.18 001265745.1_29622001_3 - 9.6e-39 131.0 0.4 2.5e-38 129.7 0.5 1.7 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.3 001265745.1_29622001_3 - 1.2e-29 101.5 0.1 2.3e-29 100.7 0.1 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.10 001265745.1_29622001_3 - 7e-22 77.1 6.4 1.5e-21 76.1 6.4 1.6 1 0 0 1 1 1 1 RS4NT (NUC023) domain KOW PF00467.27 001265745.1_29622001_3 - 4.9e-06 26.2 1.3 2.2e-05 24.1 1.3 2.2 1 0 0 1 1 1 1 KOW motif S4 PF01479.23 001265745.1_29622001_3 - 0.00017 21.1 0.0 0.00031 20.3 0.0 1.5 1 0 0 1 1 1 1 S4 domain SQS_PSY PF00494.17 001260724.1_29625001_1 - 9.8e-42 143.1 0.0 1.3e-41 142.8 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase Octopine_DH PF02317.15 001260724.1_29625001_1 - 0.069 13.1 0.3 0.22 11.5 0.0 1.9 2 0 0 2 2 2 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain Glyco_hydro_18 PF00704.26 001265920.1_29624001_3 - 2.6e-94 316.3 0.0 3.1e-94 316.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 NTP_transferase PF00483.21 001265981.1_29623001_1 - 2.5e-49 168.0 0.0 3.9e-49 167.3 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.22 001265981.1_29623001_1 - 1.1e-10 40.6 6.1 1.6e-09 37.0 0.9 3.2 2 1 0 2 2 2 1 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.5 001265981.1_29623001_1 - 3e-10 40.5 0.0 4.3e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.4 001265981.1_29623001_1 - 0.006 16.2 5.4 0.0073 15.9 1.8 2.7 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase IspD PF01128.17 001265981.1_29623001_1 - 0.032 13.9 0.0 0.052 13.1 0.0 1.3 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase DnaJ PF00226.29 001266581.1_29624001_2 - 1.9e-26 91.8 4.8 2.7e-26 91.3 4.8 1.2 1 0 0 1 1 1 1 DnaJ domain UIM PF02809.18 001266581.1_29624001_2 - 0.0012 18.5 8.5 0.0015 18.2 4.0 2.5 2 0 0 2 2 2 1 Ubiquitin interaction motif MORN PF02493.18 001283792.1_29523001_2 - 1.1e-18 65.8 46.8 1.7e-05 24.3 0.3 7.2 7 0 0 7 7 7 6 MORN repeat UDPGP PF01704.16 001266909.2_29625001_2 - 2.8e-88 296.2 0.0 7.3e-88 294.8 0.0 1.6 1 1 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.5 001266909.2_29625001_2 - 0.09 13.0 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 MobA-like NTP transferase domain UCH PF00443.27 001266957.1_29629001_2 - 3.6e-86 288.7 0.3 5.1e-86 288.2 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_3 PF14836.4 001266957.1_29629001_2 - 4.4e-39 132.1 0.1 8.3e-39 131.2 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain DUSP PF06337.10 001266957.1_29629001_2 - 3.7e-22 78.6 1.3 1.2e-21 76.9 1.3 2.0 1 0 0 1 1 1 1 DUSP domain UCH_1 PF13423.4 001266957.1_29629001_2 - 5e-19 68.9 0.0 6.4e-11 42.3 0.0 2.5 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.4 001266957.1_29629001_2 - 2.8e-08 33.6 2.3 1.9e-07 30.9 0.0 2.6 3 0 0 3 3 3 1 Ubiquitin-specific protease C-terminal USP7_ICP0_bdg PF12436.6 001266957.1_29629001_2 - 0.00071 18.9 0.0 0.0016 17.8 0.0 1.5 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 CW_binding_1 PF01473.18 001266957.1_29629001_2 - 0.68 10.2 8.0 0.47 10.7 4.7 2.5 2 0 0 2 2 2 0 Putative cell wall binding repeat Branch PF02485.19 001280249.1_39724001_1 - 6.5e-60 202.5 0.2 8.2e-60 202.2 0.2 1.1 1 0 0 1 1 1 1 Core-2/I-Branching enzyme Hormone_recep PF00104.28 001267749.2_08026001_1 - 5.2e-30 104.4 6.8 8.8e-30 103.7 6.8 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001267749.2_08026001_1 - 6.9e-26 90.4 14.4 1.3e-25 89.5 14.4 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) CAP_N PF01213.17 001267749.2_08026001_1 - 4 6.7 6.2 8.5 5.6 6.2 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal CDC50 PF03381.13 001260817.1_29625001_1 - 1.5e-91 306.6 0.0 1.9e-91 306.3 0.0 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Ribosomal_L31e PF01198.17 001283093.1_29522001_1 - 4.6e-53 177.3 0.9 7.4e-53 176.6 0.9 1.3 1 0 0 1 1 1 1 Ribosomal protein L31e Vsr PF03852.13 001283093.1_29522001_1 - 0.023 14.4 0.0 0.049 13.4 0.0 1.5 1 0 0 1 1 1 0 DNA mismatch endonuclease Vsr Myelin_PLP PF01275.17 001265765.1_29627001_1 - 1.8e-90 302.9 24.2 1.8e-90 302.9 24.2 2.1 2 0 0 2 2 2 1 Myelin proteolipid protein (PLP or lipophilin) Ribosomal_L23 PF00276.18 001266484.1_29622001_3 - 1.5e-13 50.8 0.1 2.1e-13 50.3 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L23 MFS_1 PF07690.14 001260629.1_29629001_3 - 1.5e-34 119.4 30.0 4.7e-22 78.3 16.6 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 001260629.1_29629001_3 - 1e-28 100.3 23.1 9.7e-25 87.2 10.0 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter Pentapeptide_4 PF13599.4 001260629.1_29629001_3 - 3.4e-07 30.1 6.0 7e-07 29.2 6.0 1.4 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) MFS_4 PF06779.12 001260629.1_29629001_3 - 0.0036 16.5 7.9 0.0036 16.5 7.9 2.2 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Pentapeptide_3 PF13576.4 001260629.1_29629001_3 - 0.019 15.0 7.7 0.056 13.5 3.5 2.5 1 1 1 2 2 2 0 Pentapeptide repeats (9 copies) Ribosomal_L1 PF00687.19 001266226.1_29622001_2 - 1e-43 149.3 4.2 1.3e-43 149.0 4.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF3671 PF12420.6 001266226.1_29622001_2 - 0.067 13.1 2.5 0.11 12.4 2.5 1.4 1 1 0 1 1 1 0 Protein of unknown function Sema PF01403.17 001287480.1_08024001_1 - 4.5e-85 285.8 0.2 1.6e-84 284.0 0.0 1.7 2 0 0 2 2 2 1 Sema domain Ig_2 PF13895.4 001287480.1_08024001_1 - 2.1e-07 31.0 0.4 5.3e-07 29.8 0.4 1.6 1 0 0 1 1 1 1 Immunoglobulin domain PSI PF01437.23 001287480.1_08024001_1 - 1.4e-05 25.4 2.3 1.4e-05 25.4 2.3 2.4 3 0 0 3 3 3 1 Plexin repeat Ig_3 PF13927.4 001287480.1_08024001_1 - 0.00014 22.2 0.2 0.0004 20.8 0.2 1.7 1 0 0 1 1 1 1 Immunoglobulin domain FIIND PF13553.4 001287480.1_08024001_1 - 0.017 14.4 0.4 0.041 13.2 0.1 1.7 2 0 0 2 2 2 0 Function to find V-set PF07686.15 001287480.1_08024001_1 - 0.047 13.7 0.1 0.37 10.8 0.0 2.4 2 1 0 2 2 2 0 Immunoglobulin V-set domain DUF5050 PF16472.3 001287480.1_08024001_1 - 0.17 11.0 0.0 1.7 7.7 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5050) Arm PF00514.21 001266127.2_29627001_2 - 3.4e-41 137.9 18.7 2.6e-09 36.7 0.1 10.4 11 0 0 11 11 11 6 Armadillo/beta-catenin-like repeat HEAT PF02985.20 001266127.2_29627001_2 - 2.4e-07 30.3 3.8 0.23 11.7 0.0 5.9 6 0 0 6 6 5 1 HEAT repeat V-ATPase_H_N PF03224.12 001266127.2_29627001_2 - 1.8e-05 24.0 2.0 0.084 12.0 0.0 3.7 1 1 1 3 3 3 3 V-ATPase subunit H Cnd1 PF12717.5 001266127.2_29627001_2 - 2.4e-05 24.3 5.0 0.0074 16.2 0.2 4.2 4 2 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 Atx10homo_assoc PF09759.7 001266127.2_29627001_2 - 3.4e-05 23.7 2.6 0.0043 17.0 0.1 4.0 3 1 1 4 4 4 1 Spinocerebellar ataxia type 10 protein domain HEAT_2 PF13646.4 001266127.2_29627001_2 - 9.5e-05 22.6 14.8 0.00064 19.9 1.0 5.8 4 3 2 6 6 6 1 HEAT repeats Adaptin_N PF01602.18 001266127.2_29627001_2 - 0.00012 20.7 10.6 0.00014 20.5 1.4 2.8 2 1 0 2 2 2 1 Adaptin N terminal region HEAT_EZ PF13513.4 001266127.2_29627001_2 - 0.00038 20.7 11.4 4 7.9 0.1 7.3 6 2 2 8 8 8 1 HEAT-like repeat DUF3361 PF11841.6 001266127.2_29627001_2 - 0.0012 18.7 4.7 0.31 10.8 0.3 4.5 3 2 1 4 4 4 1 Domain of unknown function (DUF3361) KAP PF05804.10 001266127.2_29627001_2 - 0.011 13.7 1.7 1.5 6.7 0.1 3.2 2 1 1 4 4 4 0 Kinesin-associated protein (KAP) RasGEF_N_2 PF14663.4 001266127.2_29627001_2 - 0.012 15.8 3.1 44 4.3 0.0 4.4 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Arm_2 PF04826.11 001266127.2_29627001_2 - 0.032 13.6 6.1 0.88 8.8 0.3 4.6 3 2 3 6 6 6 0 Armadillo-like PUL PF08324.9 001266127.2_29627001_2 - 0.19 10.9 5.2 0.13 11.4 0.3 2.6 2 1 0 2 2 2 0 PUL domain OAF PF14941.4 001265793.1_29624001_1 - 6.8e-105 349.7 0.0 8.2e-105 349.5 0.0 1.1 1 0 0 1 1 1 1 Transcriptional regulator, Out at first UBX PF00789.18 001265793.1_29624001_1 - 0.15 12.1 0.1 2.6 8.2 0.0 2.2 1 1 1 2 2 2 0 UBX domain Med27 PF11571.6 001266508.1_29623001_3 - 4.8e-27 94.0 0.2 1.1e-26 92.9 0.2 1.6 1 0 0 1 1 1 1 Mediator complex subunit 27 AAA_2 PF07724.12 001261302.1_29626001_1 - 3.5e-45 154.0 0.2 6.2e-45 153.2 0.2 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Ank_2 PF12796.5 001261302.1_29626001_1 - 1e-18 67.6 0.5 8.2e-09 35.8 0.2 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 001261302.1_29626001_1 - 2e-16 59.4 2.1 7.8e-05 22.8 0.1 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.4 001261302.1_29626001_1 - 3.5e-15 55.7 2.5 8.5e-07 29.0 0.2 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 001261302.1_29626001_1 - 7.2e-14 50.4 0.5 0.00032 20.8 0.1 4.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.4 001261302.1_29626001_1 - 4.8e-10 39.6 0.2 7.2e-05 23.1 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) ClpB_D2-small PF10431.7 001261302.1_29626001_1 - 1.4e-09 37.7 0.0 4.4e-09 36.1 0.0 1.9 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.12 001261302.1_29626001_1 - 9.9e-09 35.2 0.0 2.9e-08 33.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.27 001261302.1_29626001_1 - 5.3e-08 33.2 0.0 3.1e-07 30.8 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.24 001261302.1_29626001_1 - 1.8e-05 24.4 0.4 6.7e-05 22.5 0.1 1.9 1 1 1 2 2 2 1 Sigma-54 interaction domain Zeta_toxin PF06414.10 001261302.1_29626001_1 - 4.2e-05 22.8 0.0 9e-05 21.7 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.4 001261302.1_29626001_1 - 0.0078 16.5 0.0 0.18 12.1 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain Torsin PF06309.9 001261302.1_29626001_1 - 0.0093 15.9 0.0 0.023 14.7 0.0 1.6 1 0 0 1 1 1 1 Torsin AAA_22 PF13401.4 001261302.1_29626001_1 - 0.035 14.2 0.0 0.091 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.4 001261302.1_29626001_1 - 0.037 13.6 0.0 0.064 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.9 001261302.1_29626001_1 - 0.04 13.7 0.1 0.34 10.6 0.0 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.4 001261302.1_29626001_1 - 0.054 13.5 1.5 1.4 8.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain YchF-GTPase_C PF06071.11 001261302.1_29626001_1 - 0.055 13.5 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF933) Xpo1 PF08389.10 001266942.1_29629001_1 - 4e-32 111.2 5.1 4e-32 111.2 5.1 2.2 2 0 0 2 2 2 1 Exportin 1-like protein IBN_N PF03810.17 001266942.1_29629001_1 - 0.00052 19.7 1.1 0.002 17.8 0.0 2.7 3 0 0 3 3 3 1 Importin-beta N-terminal domain DUF1548 PF07579.9 001266942.1_29629001_1 - 0.023 14.9 0.0 9.4 6.4 0.1 2.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1548) Acetyltransf_1 PF00583.23 001260699.1_29624001_2 - 1.2e-10 41.5 0.0 1.9e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.5 001260699.1_29624001_2 - 8.5e-08 32.4 0.0 1.4e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.5 001260699.1_29624001_2 - 3.5e-07 30.1 0.0 5.5e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.5 001260699.1_29624001_2 - 0.031 14.4 0.0 0.047 13.8 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain NTP_transferase PF00483.21 001260654.1_29624001_2 - 3e-16 59.6 0.0 5.8e-16 58.7 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.5 001260654.1_29624001_2 - 2.4e-15 57.1 0.0 3.7e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain DUF4954 PF16314.3 001260654.1_29624001_2 - 3.9e-05 21.9 1.1 5.6e-05 21.4 1.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Hexapep PF00132.22 001260654.1_29624001_2 - 5.9e-05 22.5 3.9 0.085 12.5 0.1 3.9 1 1 2 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.10 001260654.1_29624001_2 - 0.018 14.0 1.0 0.041 12.8 1.0 1.6 1 0 0 1 1 1 0 L-fucokinase CTP_transf_3 PF02348.17 001260654.1_29624001_2 - 0.025 14.4 0.1 0.097 12.4 0.0 1.8 2 0 0 2 2 2 0 Cytidylyltransferase Osteopontin PF00865.16 001261806.2_29623001_3 - 4.9e-156 518.5 49.5 5.7e-156 518.2 49.5 1.0 1 0 0 1 1 1 1 Osteopontin Cys_knot PF00007.20 001266896.1_29625001_2 - 6.7e-11 42.3 13.2 6.7e-11 42.3 13.2 4.2 4 0 0 4 4 4 1 Cystine-knot domain IGFBP PF00219.16 001266896.1_29625001_2 - 7.8e-11 42.3 22.7 7.8e-11 42.3 22.7 6.2 5 3 1 6 6 6 1 Insulin-like growth factor binding protein VWC PF00093.16 001266896.1_29625001_2 - 1.1e-09 38.3 11.7 1.1e-09 38.3 11.7 5.4 4 1 1 5 5 5 1 von Willebrand factor type C domain Ribosomal_S18 PF01084.18 001266126.1_29622001_3 - 4.4e-22 77.9 0.6 2.8e-21 75.3 0.1 2.3 2 0 0 2 2 2 1 Ribosomal protein S18 Churchill PF06573.9 001266126.1_29622001_3 - 0.012 15.8 0.0 0.018 15.2 0.0 1.3 1 0 0 1 1 1 0 Churchill protein Cript PF10235.7 001266126.1_29622001_3 - 0.034 14.6 1.7 0.092 13.2 1.7 1.7 1 1 0 1 1 1 0 Microtubule-associated protein CRIPT Med4 PF10018.7 001265782.1_29623001_2 - 2.5e-31 108.8 0.3 3.9e-31 108.1 0.3 1.2 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 HMMR_N PF15905.3 001265782.1_29623001_2 - 0.00098 18.6 9.7 0.0014 18.0 9.7 1.2 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal Mu-like_Pro PF10123.7 001265782.1_29623001_2 - 0.0044 16.5 5.8 0.0097 15.3 5.6 1.6 1 1 0 1 1 1 1 Mu-like prophage I protein ALIX_LYPXL_bnd PF13949.4 001265782.1_29623001_2 - 0.013 14.7 7.3 0.019 14.1 7.3 1.2 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV DUF724 PF05266.12 001265782.1_29623001_2 - 0.22 11.2 5.8 0.41 10.3 5.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) FAM76 PF16046.3 001265782.1_29623001_2 - 0.38 9.9 4.5 0.51 9.5 4.5 1.2 1 0 0 1 1 1 0 FAM76 protein Phage_GPO PF05929.9 001265782.1_29623001_2 - 0.46 9.9 4.8 0.66 9.4 4.8 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF4094 PF13334.4 001265782.1_29623001_2 - 0.76 10.1 4.6 0.24 11.7 1.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) Spc7 PF08317.9 001265782.1_29623001_2 - 1.2 7.8 11.5 1.7 7.3 11.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein vATP-synt_E PF01991.16 001285163.1_29524001_3 - 0.025 13.8 0.1 0.059 12.6 0.1 1.6 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit Kinetocho_Slk19 PF12709.5 001285163.1_29524001_3 - 0.15 12.3 3.8 0.24 11.8 0.2 2.5 2 0 0 2 2 2 0 Central kinetochore-associated zf-C4H2 PF10146.7 001285163.1_29524001_3 - 0.32 11.1 9.1 3.8 7.6 9.1 2.5 1 1 0 1 1 1 0 Zinc finger-containing protein CENP-F_leu_zip PF10473.7 001285163.1_29524001_3 - 0.34 10.8 6.7 3.3 7.6 1.5 2.4 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CC2-LZ PF16516.3 001285163.1_29524001_3 - 0.52 10.5 7.0 0.86 9.8 0.9 2.4 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Ribosomal_S11 PF00411.17 001261578.2_29622001_2 - 7.7e-27 93.7 2.4 7.7e-27 93.7 2.4 1.6 2 0 0 2 2 2 1 Ribosomal protein S11 SYCE1 PF15233.4 001283833.1_29523001_2 - 4.2e-61 205.3 28.2 4.2e-61 205.3 28.2 2.6 3 0 0 3 3 3 2 Synaptonemal complex central element protein 1 DUF745 PF05335.11 001283833.1_29523001_2 - 0.092 12.3 32.7 0.32 10.6 12.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Reo_sigmaC PF04582.10 001283833.1_29523001_2 - 1.5 8.1 2.8 1.1 8.4 0.5 1.8 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Golgin_A5 PF09787.7 001283833.1_29523001_2 - 1.5 8.1 35.4 0.089 12.1 7.6 2.4 2 1 0 2 2 2 0 Golgin subfamily A member 5 JmjC PF02373.20 001266448.2_29629001_3 - 7.4e-43 145.5 0.0 1.2e-42 144.8 0.0 1.4 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.4 001266448.2_29629001_3 - 3.6e-36 123.5 9.9 1.1e-35 122.0 9.9 1.9 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.4 001266448.2_29629001_3 - 2.2e-19 69.4 5.8 2.2e-19 69.4 5.8 3.0 3 0 0 3 3 3 1 PHD-like zinc-binding domain JmjN PF02375.15 001266448.2_29629001_3 - 1.3e-14 53.7 0.1 3.1e-14 52.5 0.1 1.7 1 0 0 1 1 1 1 jmjN domain PHD_2 PF13831.4 001266448.2_29629001_3 - 1.7e-13 49.7 5.2 1.7e-13 49.7 5.2 2.9 2 0 0 2 2 2 1 PHD-finger LBR_tudor PF09465.8 001266448.2_29629001_3 - 4.4e-07 29.5 0.2 0.00082 19.0 0.0 2.4 2 0 0 2 2 2 2 Lamin-B receptor of TUDOR domain PHD PF00628.27 001266448.2_29629001_3 - 7.7e-05 22.4 2.5 7.7e-05 22.4 2.5 3.1 3 0 0 3 3 3 2 PHD-finger DUF4537 PF15057.4 001266448.2_29629001_3 - 0.0067 16.3 0.1 0.71 9.7 0.1 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4537) 53-BP1_Tudor PF09038.8 001266448.2_29629001_3 - 0.046 13.6 0.0 4.1 7.2 0.0 2.4 2 0 0 2 2 2 0 Tumour suppressor p53-binding protein-1 Tudor AKAP95 PF04988.10 001260986.2_29625001_3 - 7.1e-74 247.4 7.6 1.1e-73 246.7 7.6 1.3 1 0 0 1 1 1 1 A-kinase anchoring protein 95 (AKAP95) Actin_micro PF17003.3 001260986.2_29625001_3 - 0.59 9.1 12.2 0.35 9.8 3.6 2.1 1 1 1 2 2 2 0 Putative actin-like family zf-C2H2_2 PF12756.5 001260986.2_29625001_3 - 2 8.7 8.9 3.8 7.8 1.4 2.3 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.5 001260986.2_29625001_3 - 3.6 8.0 5.8 0.32 11.3 0.8 1.9 2 0 0 2 2 2 0 Zinc-finger of C2H2 type COX17 PF05051.11 001267539.1_29621001_1 - 2.5e-21 75.6 6.8 3.4e-21 75.2 6.8 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) GSG-1 PF07803.9 001260871.1_29627001_1 - 2e-17 63.0 0.1 3.7e-17 62.2 0.1 1.3 1 0 0 1 1 1 1 GSG1-like protein Rubis-subs-bind PF09273.9 001260871.1_29627001_3 - 6e-33 114.1 0.1 1.1e-32 113.3 0.1 1.5 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.26 001260871.1_29627001_3 - 5.5e-15 56.0 0.1 1.3e-13 51.5 0.0 2.3 2 0 0 2 2 2 1 SET domain PA28_beta PF02252.16 001261290.1_29622001_1 - 4.5e-60 201.4 0.2 7.5e-60 200.7 0.2 1.4 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.16 001261290.1_29622001_1 - 3e-24 84.9 1.0 8.8e-24 83.3 1.0 1.9 1 0 0 1 1 1 1 Proteasome activator pa28 alpha subunit RNase_H2-Ydr279 PF09468.8 001261290.1_29622001_1 - 0.017 14.6 0.4 0.02 14.3 0.4 1.2 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Sas10_Utp3 PF04000.13 001266254.1_29623001_1 - 1.3e-14 54.4 1.0 1.9e-13 50.7 0.3 2.8 3 0 0 3 3 3 1 Sas10/Utp3/C1D family TMEM247 PF15444.4 001266254.1_29623001_1 - 0.21 11.5 3.7 0.49 10.3 3.7 1.6 1 0 0 1 1 1 0 Transmembrane protein 247 APG6 PF04111.10 001266254.1_29623001_1 - 3.8 6.7 7.3 1.5 8.0 4.5 1.6 2 0 0 2 2 2 0 Autophagy protein Apg6 DUF737 PF05300.9 001266250.1_29623001_3 - 1.4e-50 172.3 37.6 5.1e-37 128.1 31.2 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF737) CHCH PF06747.11 001266250.1_29623001_3 - 6.3e-05 22.9 2.3 0.00012 21.9 2.3 1.4 1 0 0 1 1 1 1 CHCH domain NDUF_B7 PF05676.11 001266250.1_29623001_3 - 0.035 13.7 3.5 0.08 12.5 3.5 1.6 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DUF1948 PF09185.8 001266250.1_29623001_3 - 0.13 11.8 1.5 0.23 11.1 1.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1948) DUF1690 PF07956.9 001266250.1_29623001_3 - 0.55 10.5 25.3 2.6 8.3 18.3 2.3 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) ECH_2 PF16113.3 001266250.1_29623001_3 - 1.1 8.5 6.5 1.7 8.0 6.5 1.2 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase SAM_1 PF00536.28 001267763.1_08029001_1 - 9.4e-21 73.9 0.1 1.7e-20 73.1 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ank_2 PF12796.5 001267763.1_08029001_1 - 1.5e-20 73.5 4.3 1.8e-09 37.9 0.6 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001267763.1_08029001_1 - 2.2e-15 56.7 7.9 4.5e-07 30.2 0.3 5.9 1 1 5 6 6 6 5 Ankyrin repeats (many copies) SAM_2 PF07647.15 001267763.1_08029001_1 - 7.1e-13 48.3 0.1 1.3e-12 47.5 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) FERM_f0 PF16511.3 001267763.1_08029001_1 - 9.8e-12 44.9 0.0 1.7e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 N-terminal or F0 domain of Talin-head FERM SH3_2 PF07653.15 001267763.1_08029001_1 - 2.1e-11 43.2 0.2 4.9e-11 42.0 0.2 1.7 1 0 0 1 1 1 1 Variant SH3 domain Ank_5 PF13857.4 001267763.1_08029001_1 - 1.5e-10 41.0 8.3 0.00066 19.9 0.5 4.6 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.28 001267763.1_08029001_1 - 8.4e-09 35.4 12.6 0.0011 19.2 0.0 5.7 6 0 0 6 6 5 3 Ankyrin repeat SH3_9 PF14604.4 001267763.1_08029001_1 - 2.1e-08 33.7 0.0 4.4e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Ank_3 PF13606.4 001267763.1_08029001_1 - 2.3e-08 33.5 5.6 0.58 10.8 0.0 6.8 7 0 0 7 7 6 2 Ankyrin repeat PDZ PF00595.22 001267763.1_08029001_1 - 1.3e-06 28.5 0.0 3.2e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) SH3_1 PF00018.26 001267763.1_08029001_1 - 2.2e-05 23.9 0.0 3.9e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain Pou PF00157.15 001285673.1_09022001_1 - 6.6e-36 122.0 0.9 3.3e-34 116.6 0.3 2.4 2 0 0 2 2 2 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 001285673.1_09022001_1 - 5.2e-17 61.3 2.8 1.4e-16 59.9 2.8 1.7 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001285673.1_09022001_1 - 0.021 14.6 0.1 0.073 12.8 0.1 2.0 1 0 0 1 1 1 0 Homeobox KN domain HTH_31 PF13560.4 001285673.1_09022001_1 - 0.066 13.4 0.0 2.9 8.2 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Lsr2 PF11774.6 001285673.1_09022001_1 - 0.075 13.0 0.8 0.15 12.1 0.8 1.5 1 1 0 1 1 1 0 Lsr2 ABC_membrane PF00664.21 001261296.1_29627001_3 - 2.6e-59 201.0 15.4 4.6e-59 200.2 15.4 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.25 001261296.1_29627001_3 - 9.9e-32 110.2 0.0 2.5e-31 108.9 0.0 1.7 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.17 001261296.1_29627001_3 - 5.6e-09 35.6 0.4 7.9e-06 25.3 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 001261296.1_29627001_3 - 0.00081 19.7 0.0 0.0019 18.4 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 001261296.1_29627001_3 - 0.0023 18.0 0.0 0.01 16.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.14 001261296.1_29627001_3 - 0.0029 17.4 0.0 0.0059 16.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 MCU PF04678.11 001261296.1_29627001_3 - 0.008 16.2 0.1 0.017 15.2 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial calcium uniporter DUF4191 PF13829.4 001261296.1_29627001_3 - 0.011 15.0 0.1 0.011 15.0 0.1 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4191) AAA_29 PF13555.4 001261296.1_29627001_3 - 0.012 15.2 0.0 0.028 14.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_membrane_3 PF13748.4 001261296.1_29627001_3 - 0.021 14.0 4.9 0.061 12.4 4.9 1.8 1 1 0 1 1 1 0 ABC transporter transmembrane region AAA_30 PF13604.4 001261296.1_29627001_3 - 0.079 12.5 0.1 0.37 10.3 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.4 001261296.1_29627001_3 - 0.12 11.9 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain ATP_bind_1 PF03029.15 001261296.1_29627001_3 - 0.18 11.4 0.7 7.9 6.0 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein SbcCD_C PF13558.4 001261296.1_29627001_3 - 0.23 11.6 0.9 2 8.6 0.9 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit UDPG_MGDP_dh_N PF03721.12 001261103.1_29624001_1 - 2.1e-60 203.4 0.0 3.2e-60 202.8 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.13 001261103.1_29624001_1 - 1.7e-36 124.7 0.0 8.9e-35 119.2 0.0 2.5 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.17 001261103.1_29624001_1 - 9.5e-33 112.2 0.1 2.1e-32 111.0 0.1 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain 3HCDH_N PF02737.16 001261103.1_29624001_1 - 0.025 14.3 0.0 0.8 9.4 0.0 2.4 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.16 001261103.1_29624001_1 - 0.036 14.2 0.0 0.079 13.1 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain AlaDh_PNT_C PF01262.19 001261103.1_29624001_1 - 0.1 11.7 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NUDIX PF00293.26 001261225.1_29622001_3 - 2.3e-15 56.7 0.0 3.3e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain UDPGP PF01704.16 001261518.1_29624001_3 - 3.5e-198 658.2 0.1 4.2e-198 658.0 0.1 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Glyco_hydro_56 PF01630.16 001260524.1_29624001_1 - 6.2e-138 459.2 0.0 7.6e-138 459.0 0.0 1.1 1 0 0 1 1 1 1 Hyaluronidase EGF PF00008.25 001260524.1_29624001_1 - 0.0044 17.2 4.8 0.37 11.0 0.1 2.6 2 0 0 2 2 2 2 EGF-like domain Laps PF10169.7 001266795.2_29622001_3 - 6.5e-42 143.0 23.3 8.8e-42 142.6 23.3 1.1 1 0 0 1 1 1 1 Learning-associated protein DUF2423 PF10338.7 001266795.2_29622001_3 - 0.0019 18.2 9.2 0.0019 18.2 9.2 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF2423) PRMT5 PF05185.14 001258067.1_29625001_2 - 2.5e-180 600.3 0.1 3e-180 600.0 0.1 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase SAMBD PF16950.3 001258067.1_29625001_2 - 1.9e-104 349.3 1.2 1e-78 264.8 0.2 2.1 1 1 1 2 2 2 2 SAM-binding_domain Met_10 PF02475.14 001258067.1_29625001_2 - 0.009 15.6 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.12 001258067.1_29625001_2 - 0.009 15.4 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain FA_hydroxylase PF04116.11 001260803.1_29623001_1 - 3.8e-28 98.3 14.8 7.3e-28 97.4 14.8 1.5 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily UPF0121 PF03661.11 001261135.1_29624001_2 - 3.1e-95 317.9 12.8 4.5e-95 317.4 12.8 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) DnaJ_C PF01556.16 001277937.1_29625001_3 - 1.9e-42 144.7 0.0 2.6e-42 144.3 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.29 001277937.1_29625001_3 - 7.1e-28 96.4 2.7 1.2e-27 95.6 2.7 1.4 1 0 0 1 1 1 1 DnaJ domain Ldl_recept_b PF00058.15 001257719.1_29629001_3 - 8e-154 499.8 42.1 2.2e-13 50.3 0.1 20.5 20 0 0 20 20 20 20 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 001257719.1_29629001_3 - 2.9e-37 126.5 67.3 5.8e-12 45.6 4.6 5.4 6 0 0 6 6 6 4 Coagulation Factor Xa inhibitory site Ldl_recept_a PF00057.16 001257719.1_29629001_3 - 1.1e-31 108.6 45.3 6.6e-11 42.1 6.9 3.8 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A DUF5050 PF16472.3 001257719.1_29629001_3 - 1.4e-19 70.3 0.0 1.3e-05 24.4 0.0 6.1 4 2 1 6 6 6 5 Domain of unknown function (DUF5050) SGL PF08450.10 001257719.1_29629001_3 - 9.7e-18 64.5 16.3 0.0071 15.8 0.0 11.3 6 4 3 10 10 10 5 SMP-30/Gluconolaconase/LRE-like region cEGF PF12662.5 001257719.1_29629001_3 - 1.6e-05 24.6 16.7 0.017 14.9 0.7 5.0 4 0 0 4 4 4 3 Complement Clr-like EGF-like NHL PF01436.19 001257719.1_29629001_3 - 0.0073 16.2 0.1 31 4.7 0.0 5.4 5 0 0 5 5 5 0 NHL repeat Lactonase PF10282.7 001257719.1_29629001_3 - 0.17 11.0 0.0 32 3.5 0.0 3.7 5 0 0 5 5 5 0 Lactonase, 7-bladed beta-propeller YoeB_toxin PF06769.12 001257719.1_29629001_3 - 0.68 9.9 3.8 49 3.9 0.1 4.2 5 0 0 5 5 5 0 YoeB-like toxin of bacterial type II toxin-antitoxin system ERM PF00769.17 001257696.1_29628001_3 - 4.6e-69 232.8 68.9 4.6e-69 232.8 68.9 2.1 1 1 1 2 2 2 1 Ezrin/radixin/moesin family FERM_C PF09380.8 001257696.1_29628001_3 - 3.9e-27 94.3 0.0 9.3e-27 93.1 0.0 1.7 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.16 001257696.1_29628001_3 - 2.9e-26 92.1 0.2 2.9e-26 92.1 0.2 3.3 2 1 0 3 3 3 1 FERM central domain FERM_N PF09379.8 001257696.1_29628001_3 - 2.8e-14 52.7 0.5 1.5e-13 50.3 0.1 2.2 2 0 0 2 2 2 1 FERM N-terminal domain DUF4750 PF15938.3 001261719.1_29624001_2 - 7.8e-19 67.0 8.0 7.8e-19 67.0 8.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4750) HTH_Tnp_Tc5 PF03221.14 001261719.1_29624001_3 - 5.8e-14 51.7 0.0 1e-13 51.0 0.0 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain BrkDBD PF09607.8 001261719.1_29624001_3 - 0.051 13.2 0.2 0.089 12.5 0.2 1.4 1 0 0 1 1 1 0 Brinker DNA-binding domain HTH_Tnp_IS630 PF01710.14 001261719.1_29624001_3 - 0.074 13.0 0.1 0.12 12.3 0.1 1.3 1 0 0 1 1 1 0 Transposase SNF2_N PF00176.21 001266324.1_29628001_1 - 3.9e-79 265.8 0.7 7.1e-79 264.9 0.2 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain SLIDE PF09111.8 001266324.1_29628001_1 - 1.6e-43 147.2 2.4 4.5e-43 145.8 2.4 1.9 1 0 0 1 1 1 1 SLIDE HAND PF09110.9 001266324.1_29628001_1 - 3.7e-30 104.8 2.1 3.7e-30 104.8 2.1 3.0 2 0 0 2 2 2 1 HAND Helicase_C PF00271.29 001266324.1_29628001_1 - 3.6e-20 72.3 0.0 1.7e-19 70.1 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 001266324.1_29628001_1 - 6.8e-11 42.3 0.0 3.9e-10 39.9 0.0 2.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.27 001266324.1_29628001_1 - 4.6e-06 26.4 0.0 1.9e-05 24.4 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase HDA2-3 PF11496.6 001266324.1_29628001_1 - 5.3e-06 25.7 0.0 9.9e-06 24.8 0.0 1.4 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Myb_DNA-binding PF00249.29 001266324.1_29628001_1 - 7.8e-05 22.6 0.3 0.36 10.9 0.0 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain DBINO PF13892.4 001266324.1_29628001_1 - 0.00012 22.3 0.3 0.00012 22.3 0.3 3.4 2 0 0 2 2 2 1 DNA-binding domain ERCC3_RAD25_C PF16203.3 001266324.1_29628001_1 - 0.0015 17.7 0.0 0.0032 16.6 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Pro_isomerase PF00160.19 001266124.1_29624001_3 - 1.1e-47 162.1 0.1 1.5e-47 161.7 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD EGF PF00008.25 001260662.1_29629001_2 - 9.6e-215 693.8 538.9 1.8e-09 37.6 9.5 37.2 36 0 0 36 36 36 35 EGF-like domain hEGF PF12661.5 001260662.1_29629001_2 - 7e-129 416.5 467.7 3.1e-06 27.5 6.6 37.9 36 0 0 36 36 36 33 Human growth factor-like EGF EGF_CA PF07645.13 001260662.1_29629001_2 - 1.7e-57 191.2 538.6 7.6e-09 35.5 6.1 37.6 20 9 17 37 37 32 23 Calcium-binding EGF domain DUF3454 PF11936.6 001260662.1_29629001_2 - 2.7e-27 94.8 23.3 9.8e-27 93.0 23.3 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3454) NOD PF06816.11 001260662.1_29629001_2 - 3.1e-25 87.4 0.0 5.2e-25 86.7 0.0 1.4 1 0 0 1 1 1 1 NOTCH protein Notch PF00066.15 001260662.1_29629001_2 - 5.4e-24 84.2 55.3 2.5e-11 43.7 16.6 14.8 17 1 0 17 17 5 3 LNR domain Ank_2 PF12796.5 001260662.1_29629001_2 - 3e-23 82.1 6.9 2.3e-12 47.2 1.9 4.0 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.28 001260662.1_29629001_2 - 2.1e-22 78.4 11.7 2.8e-05 24.2 0.0 7.0 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.4 001260662.1_29629001_2 - 1.2e-20 73.1 14.5 1.6e-06 28.2 1.1 5.6 3 2 2 5 5 5 4 Ankyrin repeats (many copies) EGF_2 PF07974.11 001260662.1_29629001_2 - 1.4e-18 66.8 616.5 0.0016 18.6 1.0 37.4 36 2 2 38 38 35 23 EGF-like domain NODP PF07684.10 001260662.1_29629001_2 - 3.4e-18 65.4 0.1 5.3e-17 61.6 0.1 3.4 1 0 0 1 1 1 1 NOTCH protein Ank_3 PF13606.4 001260662.1_29629001_2 - 9.3e-14 50.1 5.1 0.071 13.6 0.0 6.8 6 0 0 6 6 6 3 Ankyrin repeat Ank_4 PF13637.4 001260662.1_29629001_2 - 1.7e-13 50.7 3.9 1.3e-05 25.5 0.0 5.1 2 1 2 5 5 5 4 Ankyrin repeats (many copies) EGF_3 PF12947.5 001260662.1_29629001_2 - 0.0016 18.5 1.1 0.0016 18.5 1.1 36.8 32 5 4 36 36 34 15 EGF domain cEGF PF12662.5 001260662.1_29629001_2 - 0.016 15.0 0.3 0.016 15.0 0.3 34.8 34 1 0 34 34 32 0 Complement Clr-like EGF-like DUF92 PF01940.14 001261114.1_29625001_3 - 8.3e-76 254.4 3.0 1.3e-75 253.7 3.0 1.3 1 0 0 1 1 1 1 Integral membrane protein DUF92 LAGLIDADG_2 PF03161.11 001261114.1_29625001_3 - 0.083 12.8 0.1 0.15 12.0 0.1 1.3 1 0 0 1 1 1 0 LAGLIDADG DNA endonuclease family Cation_ATPase_C PF00689.19 001261114.1_29625001_3 - 1.2 8.7 10.0 0.085 12.4 2.3 2.6 3 0 0 3 3 3 0 Cation transporting ATPase, C-terminus TPR_2 PF07719.15 001261196.1_29628001_3 - 7.2e-08 31.9 0.0 0.00087 19.1 0.2 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.4 001261196.1_29628001_3 - 7.3e-06 25.4 0.0 0.00036 20.0 0.1 2.3 2 0 0 2 2 2 1 TPR repeat TPR_9 PF13371.4 001261196.1_29628001_3 - 0.0002 21.3 0.2 0.0074 16.3 0.0 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.26 001261196.1_29628001_3 - 0.0015 18.2 0.0 0.25 11.1 0.1 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.4 001261196.1_29628001_3 - 0.0024 18.4 0.3 0.47 11.3 0.1 2.7 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.4 001261196.1_29628001_3 - 0.0071 16.7 0.0 1.3 9.4 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.4 001261196.1_29628001_3 - 0.048 14.2 0.0 5.1 7.7 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.4 001261196.1_29628001_3 - 0.061 13.6 0.1 10 6.6 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat PP-binding PF00550.23 001257820.1_29622001_3 - 4e-13 49.4 0.1 6.2e-13 48.8 0.1 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.4 001257820.1_29622001_3 - 0.016 15.3 0.3 0.023 14.8 0.3 1.2 1 0 0 1 1 1 0 Acyl-carrier TGF_beta PF00019.18 001285588.1_09023001_1 - 3e-27 95.4 0.1 5.9e-27 94.5 0.1 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain AAA PF00004.27 001257770.2_29626001_3 - 1.7e-35 122.2 0.0 3.3e-35 121.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.10 001257770.2_29626001_3 - 0.0001 21.5 0.0 0.00025 20.3 0.0 1.5 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.4 001257770.2_29626001_3 - 0.00061 20.0 0.6 0.23 11.6 0.1 2.3 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.4 001257770.2_29626001_3 - 0.00063 20.0 0.1 0.0031 17.8 0.0 1.9 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.12 001257770.2_29626001_3 - 0.0012 18.7 0.0 0.0052 16.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.4 001257770.2_29626001_3 - 0.0013 18.6 0.0 0.0024 17.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain TniB PF05621.9 001257770.2_29626001_3 - 0.0062 15.6 0.1 1.9 7.5 0.0 3.0 1 1 1 3 3 3 1 Bacterial TniB protein AAA_25 PF13481.4 001257770.2_29626001_3 - 0.014 14.9 0.0 3.1 7.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.19 001257770.2_29626001_3 - 0.02 14.2 0.1 0.1 11.9 0.1 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.4 001257770.2_29626001_3 - 0.029 14.7 0.1 0.12 12.8 0.0 2.1 3 0 0 3 3 2 0 AAA domain Zeta_toxin PF06414.10 001257770.2_29626001_3 - 0.051 12.7 0.0 0.094 11.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_33 PF13671.4 001257770.2_29626001_3 - 0.059 13.4 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.15 001257770.2_29626001_3 - 0.061 13.0 0.1 0.14 11.8 0.0 1.5 2 0 0 2 2 2 0 IstB-like ATP binding protein RNA_helicase PF00910.20 001257770.2_29626001_3 - 0.069 13.4 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_2 PF07724.12 001257770.2_29626001_3 - 0.083 12.9 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) TIP49 PF06068.11 001257770.2_29626001_3 - 0.13 11.1 0.0 0.22 10.3 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus AAA_21 PF13304.4 001257770.2_29626001_3 - 0.16 11.6 0.3 0.38 10.4 0.1 1.6 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system DSPc PF00782.18 001261330.1_29623001_3 - 7.8e-33 113.0 0.1 1e-32 112.6 0.1 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 001261330.1_29623001_3 - 0.0044 16.5 0.0 0.0059 16.1 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase GATase PF00117.26 001261203.1_29625001_2 - 5e-40 137.2 0.0 1.4e-39 135.7 0.0 1.8 2 0 0 2 2 2 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.20 001261203.1_29625001_2 - 2.1e-17 62.8 0.0 3.5e-10 39.7 0.0 3.2 2 1 0 2 2 2 2 GMP synthase C terminal domain Peptidase_C26 PF07722.11 001261203.1_29625001_2 - 1.5e-12 47.6 0.0 3.9e-12 46.2 0.0 1.7 1 1 0 1 1 1 1 Peptidase C26 NAD_synthase PF02540.15 001261203.1_29625001_2 - 2.7e-12 46.2 0.1 1.3e-08 34.1 0.0 2.3 2 0 0 2 2 2 2 NAD synthase QueC PF06508.11 001261203.1_29625001_2 - 5.2e-08 32.5 0.1 3.3e-07 29.9 0.0 2.0 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.14 001261203.1_29625001_2 - 9.3e-06 24.5 0.0 2.5e-05 23.1 0.0 1.7 2 0 0 2 2 2 1 tRNA methyl transferase Asn_synthase PF00733.19 001261203.1_29625001_2 - 0.00043 19.9 0.0 0.00067 19.3 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase ATP_bind_3 PF01171.18 001261203.1_29625001_2 - 0.00045 19.9 0.0 0.00085 19.0 0.0 1.4 1 0 0 1 1 1 1 PP-loop family PAPS_reduct PF01507.17 001261203.1_29625001_2 - 0.0013 18.7 0.0 0.0021 18.0 0.0 1.3 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family ThiI PF02568.12 001261203.1_29625001_2 - 0.0016 17.9 0.1 0.004 16.6 0.1 1.6 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) Arginosuc_synth PF00764.17 001261203.1_29625001_2 - 0.0023 17.1 0.0 0.004 16.4 0.0 1.3 1 0 0 1 1 1 1 Arginosuccinate synthase rve PF00665.24 001261203.1_29625001_2 - 0.054 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain 7tm_1 PF00001.19 001266071.1_29624001_3 - 1.5e-23 83.2 11.3 2.7e-23 82.4 11.3 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TNRC6-PABC_bdg PF16608.3 001260746.1_29629001_1 - 1.1e-124 415.8 40.3 1.1e-124 415.8 40.3 6.0 6 1 0 6 6 6 1 TNRC6-PABC binding domain M_domain PF12938.5 001260746.1_29629001_1 - 1.1e-71 241.4 37.5 1.1e-71 241.4 37.5 4.0 3 1 3 6 6 6 1 M domain of GW182 Ago_hook PF10427.7 001260746.1_29629001_1 - 2e-21 77.1 25.0 2e-21 77.1 25.0 10.6 3 3 4 8 8 8 1 Argonaute hook UBA PF00627.29 001260746.1_29629001_1 - 9e-06 25.3 0.0 1.7e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain RRM_1 PF00076.20 001260746.1_29629001_1 - 0.00026 20.6 0.0 0.00044 19.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001260746.1_29629001_1 - 0.027 14.2 0.0 0.049 13.4 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif THOC7 PF05615.11 001260746.1_29629001_1 - 1.6 8.9 6.8 2.9 8.1 6.8 1.3 1 0 0 1 1 1 0 Tho complex subunit 7 RhoGEF67_u2 PF16614.3 001266573.1_29628001_1 - 9.2e-63 209.0 1.1 9.2e-63 209.0 1.1 2.1 2 0 0 2 2 2 1 Unstructured region two on RhoGEF 6 and 7 betaPIX_CC PF16523.3 001266573.1_29628001_1 - 5.8e-36 122.0 9.2 5.8e-36 122.0 9.2 2.6 2 0 0 2 2 2 1 betaPIX coiled coil RhoGEF PF00621.18 001266573.1_29628001_1 - 4e-31 108.5 2.3 4e-31 108.5 2.3 2.5 4 0 0 4 4 4 1 RhoGEF domain CH PF00307.29 001266573.1_29628001_1 - 7.6e-18 64.6 0.1 1.7e-17 63.4 0.1 1.7 1 0 0 1 1 1 1 Calponin homology (CH) domain SH3_9 PF14604.4 001266573.1_29628001_1 - 4e-17 61.7 0.1 8e-17 60.7 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001266573.1_29628001_1 - 1.7e-16 59.5 0.4 3.3e-16 58.6 0.4 1.5 1 0 0 1 1 1 1 Variant SH3 domain RhoGEF67_u1 PF16615.3 001266573.1_29628001_1 - 2.7e-15 56.6 8.0 2.7e-15 56.6 8.0 3.0 2 0 0 2 2 1 1 Unstructured region one on RhoGEF 6 and 7 SH3_1 PF00018.26 001266573.1_29628001_1 - 5.1e-14 51.5 0.1 9.1e-14 50.7 0.1 1.4 1 0 0 1 1 1 1 SH3 domain PH PF00169.27 001266573.1_29628001_1 - 5.3e-10 39.6 0.0 1.3e-09 38.3 0.0 1.7 1 0 0 1 1 1 1 PH domain CAMSAP_CH PF11971.6 001266573.1_29628001_1 - 0.00063 19.4 0.1 0.0016 18.1 0.1 1.6 1 0 0 1 1 1 1 CAMSAP CH domain Nsp1_C PF05064.11 001266573.1_29628001_1 - 0.38 10.4 2.7 1.2 8.8 2.7 1.8 1 0 0 1 1 1 0 Nsp1-like C-terminal region DUF2935 PF11155.6 001266573.1_29628001_1 - 0.4 10.9 3.8 2.6 8.3 0.8 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) ZapB PF06005.10 001266573.1_29628001_1 - 1.2 9.5 10.3 0.22 11.8 5.8 2.2 2 0 0 2 2 1 0 Cell division protein ZapB CENP-Q PF13094.4 001266573.1_29628001_1 - 1.9 8.5 12.9 0.5 10.4 8.2 2.4 2 1 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Ran_BP1 PF00638.16 001260864.2_29622001_3 - 1.2e-55 186.9 0.6 1.2e-55 186.9 0.6 1.8 2 0 0 2 2 2 1 RanBP1 domain VID27 PF08553.8 001260864.2_29622001_3 - 0.013 14.0 3.3 0.015 13.7 3.3 1.0 1 0 0 1 1 1 0 VID27 cytoplasmic protein RRM_1 PF00076.20 001266062.1_29623001_2 - 1.2e-12 47.3 0.0 1.8e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) eIF-4B PF06273.9 001266062.1_29623001_2 - 0.0011 18.0 2.5 0.0011 18.0 2.5 1.6 2 0 0 2 2 2 1 Plant specific eukaryotic initiation factor 4B S_100 PF01023.17 001260526.1_29622001_2 - 4.9e-21 74.0 0.9 8.4e-21 73.3 0.9 1.4 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.30 001260526.1_29622001_2 - 3.4e-06 26.1 0.6 9.8e-06 24.6 0.6 1.8 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.4 001260526.1_29622001_2 - 5.4e-06 26.7 1.3 1e-05 25.8 1.3 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 001260526.1_29622001_2 - 0.0054 16.4 0.2 0.072 12.9 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_4 PF12763.5 001260526.1_29622001_2 - 0.019 14.8 0.1 0.026 14.4 0.1 1.2 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand EF-hand_8 PF13833.4 001260526.1_29622001_2 - 0.026 14.2 1.3 0.044 13.4 1.3 1.4 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.4 001260526.1_29622001_2 - 0.028 13.8 1.6 0.034 13.6 0.3 1.9 2 0 0 2 2 2 0 EF hand DUF846 PF05832.10 001281867.1_08022001_3 - 5.7e-55 185.0 9.8 7.8e-55 184.6 9.8 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) Acyltransferase PF01553.19 001266771.1_29629001_2 - 3.8e-21 75.0 0.0 8.3e-21 73.9 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase Rep_fac_C PF08542.9 001266677.1_29623001_3 - 3.6e-21 75.2 0.1 6.8e-21 74.3 0.1 1.5 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.27 001266677.1_29623001_3 - 2.2e-17 63.6 0.0 5.7e-17 62.2 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.4 001266677.1_29623001_3 - 1.5e-12 47.4 0.0 4.9e-10 39.3 0.0 2.3 1 1 0 2 2 2 1 DNA polymerase III, delta subunit Rad17 PF03215.13 001266677.1_29623001_3 - 1.1e-09 37.7 0.0 1.2e-05 24.3 0.0 2.1 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_assoc_2 PF16193.3 001266677.1_29623001_3 - 4.2e-06 26.8 0.4 2.3e-05 24.4 0.0 2.3 3 0 0 3 3 3 1 AAA C-terminal domain AAA_16 PF13191.4 001266677.1_29623001_3 - 1.6e-05 25.2 0.1 0.0017 18.6 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain DUF815 PF05673.11 001266677.1_29623001_3 - 0.00012 21.2 0.0 0.00021 20.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_24 PF13479.4 001266677.1_29623001_3 - 0.00037 20.1 0.0 0.00099 18.8 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.4 001266677.1_29623001_3 - 0.00044 19.9 0.0 0.0051 16.4 0.0 2.1 1 1 1 2 2 2 1 AAA domain AAA_30 PF13604.4 001266677.1_29623001_3 - 0.00046 19.8 0.0 0.0016 18.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.4 001266677.1_29623001_3 - 0.0014 18.8 0.0 0.066 13.4 0.0 2.4 1 1 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.11 001266677.1_29623001_3 - 0.0019 17.9 0.4 0.0037 16.9 0.1 1.6 2 0 0 2 2 2 1 DNA polymerase III, delta subunit RuvB_N PF05496.10 001266677.1_29623001_3 - 0.0023 17.1 0.0 0.0051 16.0 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Mg_chelatase PF01078.19 001266677.1_29623001_3 - 0.0076 15.5 0.0 0.1 11.8 0.0 2.3 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.4 001266677.1_29623001_3 - 0.0093 16.2 0.0 0.095 12.9 0.0 2.2 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.7 001266677.1_29623001_3 - 0.03 13.4 0.0 0.28 10.3 0.0 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ResIII PF04851.13 001266677.1_29623001_3 - 0.037 13.9 0.0 0.11 12.4 0.0 1.9 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_5 PF07728.12 001266677.1_29623001_3 - 0.044 13.7 0.1 0.39 10.6 0.1 2.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) DEAD PF00270.27 001266677.1_29623001_3 - 0.074 12.7 0.3 1.7 8.2 0.0 2.7 2 1 0 3 3 3 0 DEAD/DEAH box helicase Viral_helicase1 PF01443.16 001266677.1_29623001_3 - 0.088 12.4 0.0 0.67 9.5 0.0 2.3 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.4 001266677.1_29623001_3 - 0.12 12.5 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain zf-H2C2_2 PF13465.4 001260644.1_29627001_1 - 0.02 15.2 0.4 0.053 13.9 0.4 1.8 1 0 0 1 1 1 0 Zinc-finger double domain zf-C2H2 PF00096.24 001260644.1_29627001_2 - 1.3e-68 223.7 100.2 1.1e-06 28.6 1.1 14.1 14 0 0 14 14 14 12 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001260644.1_29627001_2 - 6.2e-59 193.8 87.6 3.4e-06 27.1 0.4 14.7 13 1 1 14 14 14 12 Zinc-finger double domain zf-C2H2_4 PF13894.4 001260644.1_29627001_2 - 2.7e-45 148.9 97.8 0.00063 20.2 0.9 14.8 14 0 0 14 14 14 13 C2H2-type zinc finger KRAB PF01352.25 001260644.1_29627001_2 - 1.7e-21 75.4 0.1 3.2e-21 74.6 0.1 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 001260644.1_29627001_2 - 1.2e-13 50.8 37.5 0.71 10.1 0.1 11.8 12 0 0 12 12 11 5 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 001260644.1_29627001_2 - 3.8e-09 36.4 52.8 0.05 13.6 0.4 9.1 5 2 3 9 9 9 6 Zinc ribbon domain DZR PF12773.5 001260644.1_29627001_2 - 7.6e-06 25.7 47.1 6.6e+02 0.3 0.0 8.5 2 1 1 3 3 2 0 Double zinc ribbon zinc_ribbon_15 PF17032.3 001260644.1_29627001_2 - 0.0018 18.8 47.5 0.63 10.7 1.1 7.1 2 1 8 10 10 9 8 zinc-ribbon family ADK_lid PF05191.12 001260644.1_29627001_2 - 0.0018 18.1 47.6 0.13 12.1 0.4 9.7 3 2 9 12 12 12 3 Adenylate kinase, active site lid FYDLN_acid PF09538.8 001260644.1_29627001_2 - 0.074 13.6 16.9 21 5.7 0.0 8.2 2 2 6 8 8 8 0 Protein of unknown function (FYDLN_acid) zf-trcl PF13451.4 001260644.1_29627001_2 - 0.39 10.5 55.1 20 5.1 0.1 13.5 14 0 0 14 14 14 0 Probable zinc-ribbon domain zf-C2H2_11 PF16622.3 001260644.1_29627001_2 - 0.45 10.2 90.9 0.39 10.4 0.9 14.4 15 0 0 15 15 14 0 zinc-finger C2H2-type XPA_N PF01286.16 001260644.1_29627001_2 - 1.3 8.9 50.1 14 5.7 0.3 12.6 14 0 0 14 14 13 0 XPA protein N-terminal DUF3268 PF11672.6 001260644.1_29627001_2 - 3.2 8.0 41.0 6.1 7.1 1.0 7.7 1 1 8 10 10 10 0 zinc-finger-containing domain zf-C2H2_6 PF13912.4 001260644.1_29627001_2 - 9.8 6.1 82.8 0.31 10.9 0.1 13.2 13 0 0 13 13 13 0 C2H2-type zinc finger HS1_rep PF02218.13 001266284.1_29627001_3 - 1.9e-109 357.6 63.5 1.5e-21 76.5 2.4 6.6 6 0 0 6 6 6 6 Repeat in HS1/Cortactin SH3_9 PF14604.4 001266284.1_29627001_3 - 1.2e-16 60.2 0.2 2.2e-16 59.3 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001266284.1_29627001_3 - 5.9e-16 57.7 0.2 1.2e-15 56.7 0.2 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 001266284.1_29627001_3 - 5.9e-09 35.4 0.0 1.2e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain TMEM210 PF15195.4 001266284.1_29627001_3 - 3.3e-06 27.4 5.5 15 5.9 0.0 6.0 1 1 4 6 6 6 2 TMEM210 family FadA PF09403.8 001266284.1_29627001_3 - 0.13 12.6 9.6 0.29 11.5 9.6 1.5 1 0 0 1 1 1 0 Adhesion protein FadA MCU PF04678.11 001266284.1_29627001_3 - 1 9.4 3.8 1.9 8.5 3.8 1.3 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Hydin_ADK PF17213.1 001266284.1_29627001_3 - 7.1 6.7 7.5 16 5.5 7.5 1.5 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Casc1_N PF15927.3 001266284.1_29627001_3 - 8.5 5.8 17.0 15 5.1 17.0 1.3 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus Ras PF00071.20 001265995.1_29622001_1 - 8.1e-61 204.2 1.8 1.1e-60 203.8 1.8 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001265995.1_29622001_1 - 8.7e-33 113.0 1.1 1.3e-32 112.4 1.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001265995.1_29622001_1 - 4.8e-14 52.0 0.2 6.7e-14 51.6 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001265995.1_29622001_1 - 3e-05 23.4 0.8 0.00037 19.9 0.0 2.2 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.25 001265995.1_29622001_1 - 0.00044 19.7 0.2 0.0011 18.4 0.1 1.6 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001265995.1_29622001_1 - 0.00044 20.2 0.1 0.00072 19.5 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001265995.1_29622001_1 - 0.00088 18.6 0.1 0.0012 18.1 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF2757 PF10955.6 001265995.1_29622001_1 - 0.0049 17.0 0.1 0.0093 16.1 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2757) FeoB_N PF02421.16 001265995.1_29622001_1 - 0.008 15.6 0.0 4 6.8 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B DUF258 PF03193.14 001265995.1_29622001_1 - 0.047 13.5 0.0 3.3 7.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Septin PF00735.16 001265995.1_29622001_1 - 0.055 12.5 0.1 1.3 8.1 0.0 2.2 2 0 0 2 2 2 0 Septin AAA_16 PF13191.4 001265995.1_29622001_1 - 0.17 12.1 0.0 0.37 11.0 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain THAP PF05485.10 001261590.1_29623001_3 - 1.2e-14 54.9 0.1 2.6e-14 53.8 0.1 1.6 1 0 0 1 1 1 1 THAP domain Tho2 PF11262.6 001261590.1_29623001_3 - 0.41 9.7 4.0 0.55 9.2 4.0 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 RhoGEF PF00621.18 001266688.1_29626001_2 - 5.1e-44 150.5 1.3 5.4e-44 150.5 0.2 1.6 2 0 0 2 2 2 1 RhoGEF domain FYVE PF01363.19 001266688.1_29626001_2 - 1.5e-17 63.4 11.9 2.6e-17 62.6 11.9 1.4 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.27 001266688.1_29626001_2 - 2.9e-17 63.0 0.0 1.3e-08 35.1 0.0 2.5 2 0 0 2 2 2 2 PH domain FYVE_2 PF02318.14 001266688.1_29626001_2 - 2e-06 27.9 3.8 4.9e-06 26.6 3.8 1.6 1 0 0 1 1 1 1 FYVE-type zinc finger PH_13 PF16652.3 001266688.1_29626001_2 - 3.3e-05 23.7 0.3 0.44 10.3 0.0 2.9 2 1 0 2 2 2 2 Pleckstrin homology domain IQ_SEC7_PH PF16453.3 001266688.1_29626001_2 - 0.00099 19.0 0.1 0.0023 17.8 0.1 1.5 1 0 0 1 1 1 1 PH domain QueF PF14489.4 001266688.1_29626001_2 - 0.13 12.3 0.4 5.8 7.0 0.0 2.4 2 0 0 2 2 2 0 QueF-like protein C1_1 PF00130.20 001266688.1_29626001_2 - 0.34 10.7 11.1 0.12 12.1 7.2 2.1 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) 4F5 PF04419.12 001286962.1_09022001_3 - 8.3e-11 42.4 10.8 8.3e-11 42.4 10.8 2.4 2 0 0 2 2 2 1 4F5 protein family TFIID-18kDa PF02269.14 001266569.1_29624001_2 - 2.4e-36 123.5 1.0 3.9e-36 122.8 0.5 1.6 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit DUF4093 PF13331.4 001266569.1_29624001_2 - 0.098 13.0 0.5 0.99 9.8 0.5 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4093) DUF3446 PF11928.6 001266569.1_29624001_2 - 3.6 7.8 9.6 1.2 9.4 1.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3446) SAM_1 PF00536.28 001284901.1_29524001_1 - 1.1e-35 121.7 0.1 2.1e-16 60.0 0.1 2.3 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 001284901.1_29524001_1 - 5.7e-29 99.9 0.5 2.4e-15 56.3 0.1 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) PID PF00640.21 001284901.1_29524001_1 - 1.4e-20 73.6 0.7 2.3e-20 73.0 0.7 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 001284901.1_29524001_1 - 9e-05 22.5 0.1 0.00015 21.8 0.1 1.3 1 0 0 1 1 1 1 Phosphotyrosine-binding domain Coq4 PF05019.11 001284901.1_29524001_1 - 0.0008 18.7 0.0 0.0024 17.1 0.0 1.6 1 1 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 PID_2 PF14719.4 001284901.1_29524001_1 - 0.0017 18.1 0.0 0.0036 17.1 0.0 1.5 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) DUF4612 PF15389.4 001260863.1_29623001_2 - 3.4e-43 147.2 6.6 5.1e-43 146.6 6.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4612) DUF846 PF05832.10 001281866.1_08022001_3 - 4.2e-55 185.5 9.8 5.9e-55 185.0 9.8 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) HXXEE PF13787.4 001281866.1_08022001_3 - 1.7 9.3 7.5 3.3 8.4 0.9 2.2 1 1 1 2 2 2 0 Protein of unknown function with HXXEE motif LIM_bind PF01803.14 001265886.1_29625001_2 - 2.5e-54 184.2 9.3 2e-43 148.5 0.5 2.6 2 1 1 3 3 3 2 LIM-domain binding protein NUDIX PF00293.26 001261782.2_29623001_2 - 3.3e-08 33.5 0.2 7.6e-08 32.3 0.2 1.6 1 1 0 1 1 1 1 NUDIX domain MSC PF09402.8 001258094.1_29629001_3 - 5.3e-19 68.8 0.1 7.8e-19 68.2 0.1 1.2 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain LEM PF03020.13 001258094.1_29629001_3 - 9.4e-18 63.4 0.2 1.9e-17 62.4 0.2 1.6 1 0 0 1 1 1 1 LEM domain RBM39linker PF15519.4 001258094.1_29629001_3 - 0.014 16.2 1.5 0.035 15.0 0.0 2.3 2 0 0 2 2 2 0 linker between RRM2 and RRM3 domains in RBM39 protein PMG PF05287.10 001285767.1_09022001_2 - 4.9e-23 82.0 48.1 7.6e-23 81.3 48.1 1.2 1 0 0 1 1 1 1 PMG protein Keratin_B2_2 PF13885.4 001285767.1_09022001_2 - 1.1e-05 25.1 72.4 0.00055 19.7 20.3 4.4 2 1 2 4 4 4 2 Keratin, high sulfur B2 protein Keratin_B2 PF01500.15 001285767.1_09022001_2 - 0.019 14.8 48.9 0.077 12.9 26.7 2.5 1 1 1 2 2 2 0 Keratin, high sulfur B2 protein ER_lumen_recept PF00810.16 001260765.1_29626001_2 - 4e-55 186.5 8.7 9.2e-55 185.4 8.7 1.7 1 0 0 1 1 1 1 ER lumen protein retaining receptor SUI1 PF01253.20 001266770.1_29624001_3 - 1.6e-19 70.1 0.0 1.1e-18 67.4 0.0 2.3 2 0 0 2 2 2 1 Translation initiation factor SUI1 PUA PF01472.18 001266770.1_29624001_3 - 0.001 18.9 0.1 0.0027 17.5 0.1 1.7 2 0 0 2 2 2 1 PUA domain DUF2771 PF10969.6 001266770.1_29624001_3 - 0.0012 18.8 0.0 0.0027 17.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2771) SWIB PF02201.16 001266770.1_29624001_3 - 0.091 12.5 0.1 0.33 10.7 0.1 1.9 1 0 0 1 1 1 0 SWIB/MDM2 domain DUF4618 PF15397.4 001283700.1_29524001_2 - 0.042 13.2 24.0 0.073 12.4 24.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) TSC22 PF01166.16 001283700.1_29524001_2 - 1.9 8.7 14.1 0.89 9.8 1.8 3.3 3 0 0 3 3 3 0 TSC-22/dip/bun family bZIP_1 PF00170.19 001283700.1_29524001_2 - 3.3 7.7 10.4 4.5 7.3 0.4 3.2 3 0 0 3 3 3 0 bZIP transcription factor Ldl_recept_a PF00057.16 001266659.1_29629001_2 - 5.3e-07 29.6 9.4 1.5e-06 28.2 9.4 1.9 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A PAS_3 PF08447.10 001285728.1_09025001_2 - 1.8e-27 95.3 0.1 1e-20 73.7 0.1 2.5 2 0 0 2 2 2 2 PAS fold HIF-1a_CTAD PF08778.8 001285728.1_09025001_2 - 2.6e-22 78.0 0.5 5.7e-22 76.9 0.5 1.6 1 0 0 1 1 1 1 HIF-1 alpha C terminal transactivation domain PAS_11 PF14598.4 001285728.1_09025001_2 - 2.4e-21 75.8 1.1 1.6e-18 66.7 0.1 2.5 2 0 0 2 2 2 2 PAS domain HIF-1 PF11413.6 001285728.1_09025001_2 - 1.1e-15 56.6 6.3 2.7e-15 55.3 6.3 1.7 1 0 0 1 1 1 1 Hypoxia-inducible factor-1 PAS PF00989.23 001285728.1_09025001_2 - 1.7e-15 56.8 0.0 5.6e-07 29.4 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.5 001285728.1_09025001_2 - 8.2e-10 38.7 0.0 0.00087 19.4 0.0 2.7 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.8 001285728.1_09025001_2 - 4e-07 30.1 0.0 0.0081 16.3 0.0 2.4 2 0 0 2 2 2 2 PAS fold HLH PF00010.24 001285728.1_09025001_2 - 0.081 12.8 0.1 0.18 11.7 0.1 1.6 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain Rab5ip PF07019.10 001266545.1_29622001_1 - 6.7e-23 81.0 8.7 8.8e-23 80.6 8.7 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) SRTM1 PF15872.3 001266545.1_29622001_1 - 0.092 12.8 0.2 0.16 12.0 0.2 1.3 1 0 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 Proteasome PF00227.24 001260636.1_29622001_2 - 2e-39 134.9 0.0 2.6e-39 134.6 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Cytochrom_C1 PF02167.13 001260636.1_29622001_2 - 0.00071 19.2 0.1 0.00099 18.8 0.1 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Gram_pos_anchor PF00746.19 001260636.1_29622001_2 - 0.12 12.2 0.0 0.3 11.0 0.0 1.6 1 0 0 1 1 1 0 Gram positive anchor REV PF00424.16 001260927.1_29624001_1 - 0.77 9.7 6.8 0.74 9.7 1.3 2.4 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) TFIIE_beta PF02186.13 001260927.1_29624001_3 - 1.7e-24 85.7 0.5 4.4e-24 84.4 0.2 1.9 2 0 0 2 2 2 1 TFIIE beta subunit core domain Dickkopf_N PF04706.10 001265749.1_29626001_2 - 4.6e-16 58.9 17.5 4.6e-16 58.9 17.5 2.9 3 0 0 3 3 3 1 Dickkopf N-terminal cysteine-rich region UPF0506 PF11703.6 001265749.1_29626001_2 - 0.0024 18.1 16.0 0.0024 18.1 16.0 2.7 3 0 0 3 3 3 1 UPF0506 HSCB_C PF07743.11 001265749.1_29626001_2 - 0.54 10.7 5.8 11 6.5 2.0 2.3 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain VHS PF00790.17 001266163.1_29625001_1 - 1.4e-46 157.8 0.0 2.6e-46 156.9 0.0 1.5 1 0 0 1 1 1 1 VHS domain GAT PF03127.12 001266163.1_29625001_1 - 4.4e-25 87.7 2.4 7.8e-25 86.9 2.4 1.4 1 0 0 1 1 1 1 GAT domain Nicastrin PF05450.13 001260780.1_29626001_2 - 1.9e-84 282.7 0.0 2.5e-84 282.2 0.0 1.2 1 0 0 1 1 1 1 Nicastrin Peptidase_M28 PF04389.15 001260780.1_29626001_2 - 4.4e-06 26.4 0.0 7.1e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Xlink PF00193.15 001265852.1_29624001_1 - 1.7e-58 194.8 0.0 8.6e-32 109.3 0.0 2.4 2 0 0 2 2 2 2 Extracellular link domain V-set PF07686.15 001265852.1_29624001_1 - 4.6e-11 42.7 0.0 8.4e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001265852.1_29624001_1 - 2e-06 28.2 0.0 4.3e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001265852.1_29624001_1 - 0.0002 21.2 0.0 0.00037 20.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 001265852.1_29624001_1 - 0.00081 19.4 0.0 0.0019 18.2 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001265852.1_29624001_1 - 0.0071 16.5 0.0 0.032 14.4 0.0 1.9 1 1 0 1 1 1 1 Immunoglobulin domain Izumo-Ig PF16706.3 001265852.1_29624001_1 - 0.011 15.6 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain GLTP PF08718.9 001257474.2_29624001_3 - 3.5e-41 140.8 0.0 4.7e-41 140.4 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) GST_N PF02798.18 001261651.1_29623001_2 - 8.9e-23 80.3 0.0 1.8e-22 79.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 001261651.1_29623001_2 - 1.5e-16 60.2 0.0 2.5e-16 59.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 001261651.1_29623001_2 - 8.1e-16 57.9 0.0 1.7e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.2 001261651.1_29623001_2 - 2.8e-05 23.7 0.1 0.0001 21.9 0.1 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 001261651.1_29623001_2 - 0.00023 20.9 0.0 0.00062 19.5 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 001261651.1_29623001_2 - 0.0019 18.4 0.0 0.004 17.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 001261651.1_29623001_2 - 0.025 14.8 0.0 0.048 13.9 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain UNC45-central PF11701.6 001257939.1_29627001_3 - 4.3e-38 130.5 10.9 2e-36 125.1 0.1 5.2 5 1 0 5 5 5 1 Myosin-binding striated muscle assembly central TPR_2 PF07719.15 001257939.1_29627001_3 - 3.9e-13 48.3 11.1 0.00013 21.7 0.0 4.2 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_1 PF00515.26 001257939.1_29627001_3 - 8.6e-12 44.2 9.7 0.0019 17.8 0.0 4.0 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_16 PF13432.4 001257939.1_29627001_3 - 5e-10 39.8 2.8 8.3e-07 29.5 0.3 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 001257939.1_29627001_3 - 2.8e-07 30.1 7.7 0.0002 21.2 0.0 4.2 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_14 PF13428.4 001257939.1_29627001_3 - 3.9e-07 30.2 3.2 0.014 16.0 0.1 5.1 2 1 2 4 4 4 2 Tetratricopeptide repeat HEAT_2 PF13646.4 001257939.1_29627001_3 - 4e-06 27.0 12.8 0.24 11.7 0.0 6.5 4 2 2 7 7 7 2 HEAT repeats TPR_11 PF13414.4 001257939.1_29627001_3 - 9.2e-06 25.1 1.0 0.0014 18.1 0.3 3.0 1 1 2 3 3 3 1 TPR repeat TPR_19 PF14559.4 001257939.1_29627001_3 - 1.1e-05 25.6 5.4 0.0041 17.5 1.8 3.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.4 001257939.1_29627001_3 - 4.3e-05 23.5 0.4 0.077 13.3 0.0 3.4 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_12 PF13424.4 001257939.1_29627001_3 - 8e-05 22.7 3.4 0.0035 17.5 2.4 3.1 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_7 PF13176.4 001257939.1_29627001_3 - 0.00023 20.8 1.6 0.082 12.9 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat Arm PF00514.21 001257939.1_29627001_3 - 0.00026 20.8 8.0 2.9 7.9 0.0 7.1 7 1 0 7 7 7 1 Armadillo/beta-catenin-like repeat ANAPC3 PF12895.5 001257939.1_29627001_3 - 0.0012 18.9 1.0 0.0053 16.8 1.0 2.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.4 001257939.1_29627001_3 - 0.0014 18.6 2.0 0.051 13.6 0.2 3.1 1 1 2 3 3 3 1 Tetratricopeptide repeat RIX1 PF08167.10 001257939.1_29627001_3 - 0.025 14.2 3.6 0.12 12.0 0.3 2.9 2 0 0 2 2 2 0 rRNA processing/ribosome biogenesis Coatomer_E PF04733.12 001257939.1_29627001_3 - 0.031 13.6 0.1 0.065 12.5 0.1 1.5 1 0 0 1 1 1 0 Coatomer epsilon subunit VasI PF11319.6 001257939.1_29627001_3 - 0.06 12.9 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Type VI secretion system VasI, EvfG, VC_A0118 TPR_6 PF13174.4 001257939.1_29627001_3 - 0.12 12.9 0.1 0.12 12.9 0.1 4.5 5 0 0 5 5 3 0 Tetratricopeptide repeat HEAT PF02985.20 001257939.1_29627001_3 - 2.1 8.7 8.4 18 5.8 0.0 6.1 6 0 0 6 6 5 0 HEAT repeat GSH_synth_ATP PF03917.15 001267743.1_08024001_1 - 3e-129 430.9 0.0 3.8e-129 430.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.13 001267743.1_08024001_1 - 2.6e-31 108.0 0.0 4.6e-31 107.2 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic glutathione synthase zf-C2H2 PF00096.24 001261298.1_29624001_3 - 1.9e-27 94.0 51.7 2.6e-05 24.3 1.2 6.6 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001261298.1_29624001_3 - 3.9e-24 83.8 58.4 4.4e-07 29.9 1.0 7.6 7 1 0 7 7 7 4 Zinc-finger double domain zf-C2H2_4 PF13894.4 001261298.1_29624001_3 - 8.6e-17 60.3 55.1 0.0021 18.6 2.3 7.1 7 0 0 7 7 6 6 C2H2-type zinc finger zf-C2HC_2 PF13913.4 001261298.1_29624001_3 - 2.1e-06 27.3 5.1 0.0043 16.8 0.6 4.6 4 0 0 4 4 4 1 zinc-finger of a C2HC-type zf-Di19 PF05605.10 001261298.1_29624001_3 - 0.0019 18.3 39.0 0.0099 16.0 10.8 4.4 2 1 2 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.6 001261298.1_29624001_3 - 0.0033 17.6 32.9 0.0099 16.0 0.4 5.9 5 1 1 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001261298.1_29624001_3 - 0.004 16.9 52.4 0.017 15.0 3.3 7.0 8 0 0 8 8 8 3 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001261298.1_29624001_3 - 0.0077 15.8 17.1 0.058 13.0 1.9 4.4 4 0 0 4 4 4 2 zinc-finger C2H2-type zf-met PF12874.5 001261298.1_29624001_3 - 0.15 12.3 45.7 0.29 11.4 2.0 6.0 6 0 0 6 6 6 0 Zinc-finger of C2H2 type zf-C2HE PF16278.3 001261298.1_29624001_3 - 1 9.8 21.9 0.87 10.0 1.3 3.8 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger C1_1 PF00130.20 001261298.1_29624001_3 - 1.9 8.3 15.7 2.3 8.1 2.7 4.2 2 2 2 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) NMD3 PF04981.11 001261298.1_29624001_3 - 2.3 7.5 10.1 0.9 8.8 1.7 2.4 2 1 0 2 2 2 0 NMD3 family Zn-ribbon_8 PF09723.8 001261298.1_29624001_3 - 2.7 8.1 25.3 0.47 10.5 2.4 4.4 3 1 1 4 4 4 0 Zinc ribbon domain PRP21_like_P PF12230.6 001261298.1_29624001_3 - 5.6 6.6 5.0 73 3.0 4.8 2.2 1 1 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein FOXP-CC PF16159.3 001261298.1_29624001_3 - 9.1 6.8 16.5 1.2 9.7 0.9 4.7 2 2 2 4 4 4 0 FOXP coiled-coil domain VHS PF00790.17 001260762.1_29627001_2 - 2.5e-46 156.9 0.1 4.8e-46 156.0 0.0 1.5 2 0 0 2 2 2 1 VHS domain GAT PF03127.12 001260762.1_29627001_2 - 4.6e-27 94.0 2.5 8.5e-27 93.2 2.5 1.5 1 0 0 1 1 1 1 GAT domain ENTH PF01417.18 001260762.1_29627001_2 - 0.039 13.9 0.0 0.071 13.0 0.0 1.3 1 0 0 1 1 1 0 ENTH domain ERG2_Sigma1R PF04622.10 001257877.1_29624001_3 - 1.1e-63 214.2 0.1 1.5e-63 213.8 0.1 1.1 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein NADH_dehy_S2_C PF06444.9 001257877.1_29624001_3 - 0.039 14.3 0.2 0.19 12.1 0.2 2.2 1 1 0 1 1 1 0 NADH dehydrogenase subunit 2 C-terminus PTPLA PF04387.12 001261129.1_29623001_2 - 3.6e-59 199.0 10.9 6e-59 198.3 10.9 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA DHHA1 PF02272.17 001261129.1_29623001_2 - 8 6.4 8.3 15 5.6 8.3 1.3 1 0 0 1 1 1 0 DHHA1 domain Transthyretin PF00576.19 001267750.1_08021001_3 - 4.1e-19 69.2 0.1 5.4e-19 68.8 0.1 1.1 1 0 0 1 1 1 1 HIUase/Transthyretin family Med9 PF07544.11 001260740.1_29623001_3 - 7.9e-22 77.0 2.7 1.1e-21 76.5 2.7 1.2 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Med21 PF11221.6 001260740.1_29623001_3 - 0.0053 16.9 15.6 0.078 13.1 15.6 2.1 1 1 0 1 1 1 1 Subunit 21 of Mediator complex TBPIP PF07106.11 001260740.1_29623001_3 - 0.048 13.3 0.8 0.068 12.8 0.8 1.1 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DEC-1_N PF04625.11 001260740.1_29623001_3 - 0.057 12.3 6.9 0.082 11.8 6.9 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region DASH_Duo1 PF08651.8 001260740.1_29623001_3 - 0.12 12.0 0.2 0.18 11.4 0.2 1.2 1 0 0 1 1 1 0 DASH complex subunit Duo1 UvrD-helicase PF00580.19 001260740.1_29623001_3 - 0.13 11.6 0.2 0.17 11.2 0.2 1.1 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain TPR_1 PF00515.26 001266114.1_29623001_3 - 6.3e-20 70.0 1.4 1.4e-06 27.7 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.15 001266114.1_29623001_3 - 6.5e-15 53.8 0.7 0.0021 17.9 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.4 001266114.1_29623001_3 - 7.9e-08 31.8 4.4 0.27 11.4 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.4 001266114.1_29623001_3 - 2.5e-07 30.1 1.1 0.053 13.1 0.0 3.3 2 1 1 3 3 3 2 TPR repeat TPR_9 PF13371.4 001266114.1_29623001_3 - 3.5e-05 23.7 0.4 0.00014 21.9 0.3 2.0 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.4 001266114.1_29623001_3 - 0.00012 22.5 0.1 0.021 15.5 0.2 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.4 001266114.1_29623001_3 - 0.00014 22.2 0.2 0.00093 19.5 0.2 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.4 001266114.1_29623001_3 - 0.00023 21.2 1.5 0.64 10.2 0.4 2.7 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_15 PF13429.4 001266114.1_29623001_3 - 0.0028 16.8 1.3 0.048 12.7 0.1 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.4 001266114.1_29623001_3 - 0.012 16.1 0.3 0.057 13.9 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3856 PF12968.5 001266114.1_29623001_3 - 0.015 15.2 0.2 2.2 8.2 0.2 2.6 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) TPR_17 PF13431.4 001266114.1_29623001_3 - 0.02 15.1 0.4 0.13 12.6 0.1 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.4 001266114.1_29623001_3 - 0.08 12.9 0.4 15 5.7 0.1 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.4 001266114.1_29623001_3 - 0.11 13.1 0.0 9.1 6.9 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat RPN7 PF10602.7 001266114.1_29623001_3 - 0.33 10.5 5.0 1 8.9 0.1 2.3 2 0 0 2 2 2 0 26S proteasome subunit RPN7 Actin PF00022.17 001258072.1_29623001_1 - 1.2e-149 498.2 0.0 3.8e-149 496.6 0.0 1.6 1 1 0 1 1 1 1 Actin ArfGap PF01412.16 001266854.1_29629001_3 - 8.6e-39 132.1 0.0 1.7e-38 131.1 0.0 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Ras PF00071.20 001266854.1_29629001_3 - 4.6e-15 55.4 0.0 9e-15 54.5 0.0 1.5 1 0 0 1 1 1 1 Ras family PH PF00169.27 001266854.1_29629001_3 - 4.6e-09 36.6 5.7 9.3e-05 22.8 0.2 3.0 3 0 0 3 3 3 2 PH domain Ank_2 PF12796.5 001266854.1_29629001_3 - 4.5e-07 30.2 0.1 9.9e-07 29.1 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.28 001266854.1_29629001_3 - 6e-07 29.5 0.4 0.00031 20.9 0.2 2.9 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.4 001266854.1_29629001_3 - 6.2e-05 23.1 0.2 0.00014 21.9 0.2 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.4 001266854.1_29629001_3 - 0.00062 20.1 0.1 0.0021 18.5 0.1 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) PH_6 PF15406.4 001266854.1_29629001_3 - 0.0056 16.8 1.9 0.0064 16.6 0.1 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain Roc PF08477.11 001266854.1_29629001_3 - 0.014 15.5 0.3 0.036 14.2 0.0 1.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Ank_3 PF13606.4 001266854.1_29629001_3 - 0.055 13.9 0.2 0.84 10.3 0.1 2.7 2 0 0 2 2 2 0 Ankyrin repeat Spore_IV_A PF09547.8 001266854.1_29629001_3 - 0.065 12.0 0.0 0.096 11.5 0.0 1.1 1 0 0 1 1 1 0 Stage IV sporulation protein A (spore_IV_A) PH_11 PF15413.4 001266854.1_29629001_3 - 0.24 11.7 1.3 2.8 8.3 0.2 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain SPOC PF07744.11 001265669.1_29626001_1 - 3.3e-37 127.6 0.0 4.8e-37 127.1 0.0 1.2 1 0 0 1 1 1 1 SPOC domain RRM_1 PF00076.20 001265669.1_29626001_1 - 5.7e-30 102.8 0.0 3.9e-14 52.1 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 001265669.1_29626001_1 - 5.7e-05 23.0 0.0 0.001 19.0 0.0 2.5 2 0 0 2 2 2 1 RNA binding motif Nup35_RRM_2 PF14605.4 001265669.1_29626001_1 - 0.00047 19.9 0.1 0.3 10.9 0.0 3.3 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.3 001265669.1_29626001_1 - 0.01 15.8 0.0 4.5 7.3 0.0 3.4 3 0 0 3 3 3 0 RNA recognition motif GBP PF02263.17 001257493.1_29626001_3 - 4.1e-102 340.8 0.1 5.4e-102 340.4 0.1 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.12 001257493.1_29626001_3 - 4.1e-05 23.0 0.1 6.2e-05 22.4 0.1 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain RhoGAP PF00620.25 001266442.1_29627001_1 - 4.6e-44 149.8 0.1 7.7e-44 149.0 0.1 1.3 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.20 001266442.1_29627001_1 - 4.8e-07 29.4 2.4 8.5e-07 28.6 2.4 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Cep57_CLD PF14073.4 001266442.1_29627001_1 - 0.0011 18.9 3.2 0.0019 18.1 3.2 1.3 1 0 0 1 1 1 1 Centrosome localisation domain of Cep57 DUF2968 PF11180.6 001266442.1_29627001_1 - 4.7 6.7 7.4 7.7 6.0 7.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) NYD-SP28_assoc PF14775.4 001266442.1_29627001_1 - 7.4 6.6 5.8 16 5.6 0.0 3.3 3 0 0 3 3 3 0 Sperm tail C-terminal domain V-set PF07686.15 001260601.1_29624001_1 - 9.1e-09 35.3 0.2 1.4e-08 34.7 0.2 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.14 001260601.1_29624001_1 - 3.9e-07 29.9 0.2 4.2e-06 26.6 0.2 2.1 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001260601.1_29624001_1 - 1.9e-06 28.2 0.2 5e-06 26.9 0.2 1.7 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001260601.1_29624001_1 - 0.00012 22.1 0.2 0.00026 21.0 0.2 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001260601.1_29624001_1 - 0.0098 16.1 0.0 0.34 11.1 0.0 2.5 1 1 0 1 1 1 1 Immunoglobulin domain Ras PF00071.20 001260569.2_29628001_1 - 8.1e-52 174.9 0.0 1.1e-51 174.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001260569.2_29628001_1 - 3.5e-19 69.1 0.0 5.4e-19 68.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.25 001260569.2_29628001_1 - 1.5e-05 24.5 0.1 2.6e-05 23.7 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.19 001260569.2_29628001_1 - 3.2e-05 23.3 0.0 5e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 001260569.2_29628001_1 - 0.0026 17.5 0.7 0.27 11.0 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 001260569.2_29628001_1 - 0.058 13.4 0.0 0.085 12.8 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase ANKH PF07260.9 001261260.1_29628001_2 - 2.3e-219 727.3 6.1 3e-219 726.9 6.1 1.2 1 0 0 1 1 1 1 Progressive ankylosis protein (ANKH) PID PF00640.21 001266317.1_29626001_2 - 0.014 15.3 0.0 0.022 14.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) Cyclin_N PF00134.21 001265915.1_29628001_3 - 5.9e-27 93.9 1.3 5.9e-27 93.9 1.3 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 001265915.1_29628001_3 - 4.8e-19 68.4 0.2 9.6e-19 67.5 0.2 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain F-box PF00646.31 001265915.1_29628001_3 - 1.3e-07 31.2 0.3 3.5e-07 29.8 0.3 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.5 001265915.1_29628001_3 - 5e-06 26.2 0.5 1.4e-05 24.7 0.5 1.9 1 0 0 1 1 1 1 F-box-like Sel1 PF08238.10 001265915.1_29628001_3 - 0.011 16.2 0.3 68 4.2 0.0 3.6 3 0 0 3 3 3 0 Sel1 repeat Glyco_transf_8 PF01501.18 001266211.1_29624001_3 - 5e-65 219.4 0.0 6.1e-65 219.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 8 Band_7 PF01145.23 001266229.1_29623001_1 - 7.7e-35 120.4 0.5 9.7e-35 120.0 0.5 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.4 001266229.1_29623001_1 - 0.0012 18.5 0.1 0.0018 17.9 0.1 1.2 1 0 0 1 1 1 1 SPFH domain-Band 7 family SPATA6 PF14909.4 001265949.1_29626001_3 - 4.1e-52 175.9 0.0 6.5e-52 175.2 0.0 1.3 1 0 0 1 1 1 1 Spermatogenesis-assoc protein 6 CBF PF03914.15 001258179.1_29624001_2 - 2.7e-40 137.9 1.1 5.5e-40 136.9 0.7 1.7 2 0 0 2 2 2 1 CBF/Mak21 family MitoNEET_N PF10660.7 001257590.2_29625001_3 - 4e-09 36.2 0.1 9.2e-09 35.1 0.1 1.6 1 0 0 1 1 1 1 Iron-containing outer mitochondrial membrane protein N-terminus zf-CDGSH PF09360.8 001257590.2_29625001_3 - 4.1e-09 36.4 0.2 9.1e-09 35.3 0.2 1.6 1 0 0 1 1 1 1 Iron-binding zinc finger CDGSH type Pyr_redox_2 PF07992.12 001256419.1_08028001_2 - 9.7e-55 185.7 0.5 1.2e-54 185.4 0.5 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.20 001256419.1_08028001_2 - 3.3e-28 98.0 0.0 6.4e-28 97.1 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.25 001256419.1_08028001_2 - 2.8e-18 66.1 2.9 4.1e-15 56.0 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 001256419.1_08028001_2 - 9.5e-15 54.5 0.6 1.2e-10 41.0 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 001256419.1_08028001_2 - 4.3e-07 29.2 0.6 1.1e-06 27.8 0.3 1.7 2 0 0 2 2 2 1 FAD binding domain Glutaredoxin PF00462.22 001256419.1_08028001_2 - 1.6e-05 24.9 0.2 1.6e-05 24.9 0.2 2.0 2 0 0 2 2 1 1 Glutaredoxin FAD_oxidored PF12831.5 001256419.1_08028001_2 - 0.00016 21.1 0.0 0.00021 20.7 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.12 001256419.1_08028001_2 - 0.00023 19.9 0.5 0.00051 18.7 0.2 1.6 2 0 0 2 2 2 1 HI0933-like protein AlaDh_PNT_C PF01262.19 001256419.1_08028001_2 - 0.00059 19.1 0.2 0.025 13.7 0.1 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.20 001256419.1_08028001_2 - 0.0023 17.0 0.4 0.004 16.2 0.4 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.4 001256419.1_08028001_2 - 0.0046 17.0 0.3 0.0046 17.0 0.3 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.15 001256419.1_08028001_2 - 0.0055 15.8 0.6 0.013 14.6 0.0 1.8 2 0 0 2 2 2 1 Thi4 family DAO PF01266.22 001256419.1_08028001_2 - 0.012 15.2 1.0 0.017 14.6 0.2 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.17 001256419.1_08028001_2 - 0.027 13.6 3.3 0.038 13.1 0.1 2.1 2 0 0 2 2 2 0 FAD binding domain NAD_binding_7 PF13241.4 001256419.1_08028001_2 - 0.083 13.2 0.3 8.3 6.8 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding V-SNARE_C PF12352.6 001257778.1_29627001_1 - 8.8e-12 45.0 1.7 8.8e-12 45.0 1.7 1.8 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.11 001257778.1_29627001_1 - 0.00027 20.6 0.2 0.00062 19.5 0.2 1.6 1 0 0 1 1 1 1 Sec20 V-SNARE PF05008.13 001257778.1_29627001_1 - 0.053 13.8 4.6 0.086 13.1 4.6 1.3 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus IncA PF04156.12 001257778.1_29627001_1 - 6.4 6.4 9.5 11 5.7 9.5 1.2 1 0 0 1 1 1 0 IncA protein SET PF00856.26 001266274.1_29626001_3 - 2.7e-12 47.3 0.0 4.9e-12 46.4 0.0 1.5 1 0 0 1 1 1 1 SET domain Rubis-subs-bind PF09273.9 001266274.1_29626001_3 - 5.7e-10 39.9 0.1 1e-09 39.0 0.1 1.4 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding Sulfotransfer_2 PF03567.12 001260915.1_29626001_2 - 7.3e-41 140.6 0.7 1.1e-40 140.0 0.7 1.2 1 0 0 1 1 1 1 Sulfotransferase family Gal-3-0_sulfotr PF06990.9 001260915.1_29626001_2 - 0.0026 16.6 0.1 0.0037 16.1 0.1 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_1 PF00685.25 001260915.1_29626001_2 - 0.049 13.0 0.0 0.071 12.4 0.0 1.2 1 0 0 1 1 1 0 Sulfotransferase domain Zona_pellucida PF00100.21 001267734.2_08024001_2 - 2.3e-55 188.0 0.4 7.6e-55 186.3 0.3 1.7 2 0 0 2 2 2 1 Zona pellucida-like domain Trefoil PF00088.16 001267734.2_08024001_2 - 1.5e-10 40.6 6.5 4.4e-10 39.1 6.5 1.9 1 0 0 1 1 1 1 Trefoil (P-type) domain RRM_1 PF00076.20 001261256.1_29624001_2 - 6.7e-56 185.9 2.2 5.9e-19 67.5 0.0 4.0 5 0 0 5 5 5 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 001261256.1_29624001_2 - 1.6e-07 31.1 0.4 0.0075 16.2 0.0 3.4 3 0 0 3 3 3 2 RNA binding motif Limkain-b1 PF11608.6 001261256.1_29624001_2 - 7.9e-06 25.7 1.4 0.013 15.4 0.0 3.1 3 0 0 3 3 3 2 Limkain b1 RRM_5 PF13893.4 001261256.1_29624001_2 - 1e-05 25.0 0.0 0.094 12.2 0.0 3.2 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001261256.1_29624001_2 - 0.0024 17.6 0.0 0.55 10.0 0.0 2.4 2 0 0 2 2 2 2 Occluded RNA-recognition motif DbpA PF03880.13 001261256.1_29624001_2 - 0.093 12.6 0.0 11 5.9 0.0 2.5 2 0 0 2 2 2 0 DbpA RNA binding domain DTW PF03942.13 001260730.1_29623001_1 - 6.1e-46 156.5 0.0 8.7e-46 156.0 0.0 1.2 1 0 0 1 1 1 1 DTW domain Methyltransf_3 PF01596.15 001282060.1_08024001_1 - 2.5e-14 52.8 0.0 3.6e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.4 001282060.1_08024001_1 - 7.3e-10 39.7 0.0 1.4e-09 38.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.17 001282060.1_08024001_1 - 0.0027 17.3 0.0 0.004 16.8 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.4 001282060.1_08024001_1 - 0.014 15.1 0.0 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain 7tm_2 PF00002.22 001265773.1_29626001_1 - 1.8e-93 312.2 9.5 2.7e-93 311.7 9.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 001265773.1_29626001_1 - 6.9e-18 64.6 1.1 2.2e-17 63.0 1.1 1.9 1 0 0 1 1 1 1 Hormone receptor domain Dicty_CAR PF05462.9 001265773.1_29626001_1 - 0.021 13.8 12.2 0.032 13.2 12.2 1.2 1 0 0 1 1 1 0 Slime mold cyclic AMP receptor DUF2628 PF10947.6 001265773.1_29626001_1 - 1.3 9.3 5.7 4 7.7 2.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2628) Peptidase_M14 PF00246.22 001258081.1_29624001_3 - 1.5e-82 277.6 0.0 1.8e-82 277.3 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.4 001258081.1_29624001_3 - 1.4e-15 57.2 0.0 2.2e-15 56.6 0.0 1.3 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.4 001258081.1_29624001_3 - 1.6e-06 27.9 0.0 2.6e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 CarboxypepD_reg-like domain AstE_AspA PF04952.12 001258081.1_29624001_3 - 0.02 13.8 0.1 0.083 11.8 0.1 1.8 1 1 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family Tissue_fac PF01108.15 001278859.1_22424001_1 - 2.2e-19 69.1 1.6 3.1e-19 68.6 0.1 1.9 2 0 0 2 2 2 1 Tissue factor Interfer-bind PF09294.8 001278859.1_22424001_1 - 3.6e-13 49.6 0.0 7.2e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.19 001278859.1_22424001_1 - 0.1 12.9 0.0 1.1 9.6 0.0 2.4 2 0 0 2 2 2 0 Fibronectin type III domain LIAS_N PF16881.3 001261102.1_29623001_2 - 3.4e-51 172.1 0.0 7.7e-51 170.9 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.19 001261102.1_29623001_2 - 5.7e-16 59.2 0.0 8.5e-16 58.6 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily ROS_MUCR PF05443.9 001261102.1_29623001_2 - 0.065 13.2 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 ROS/MUCR transcriptional regulator protein RRM_1 PF00076.20 001261013.1_29622001_1 - 9.6e-14 50.8 0.0 1.5e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.4 001261013.1_29622001_1 - 3.9e-10 40.0 12.0 3.9e-10 40.0 12.0 3.9 3 1 1 4 4 4 1 C-terminal duplication domain of Friend of PRMT1 FYTT PF07078.9 001261013.1_29622001_1 - 0.00019 20.8 0.7 0.00019 20.8 0.7 2.0 2 1 0 2 2 2 1 Forty-two-three protein Ciart PF15673.3 001261475.1_29623001_3 - 5.5e-171 567.2 0.8 7.5e-171 566.7 0.8 1.2 1 0 0 1 1 1 1 Circadian-associated transcriptional repressor Tetraspannin PF00335.18 001266249.1_29623001_3 - 4.5e-46 157.2 13.8 4.5e-46 157.2 13.8 1.5 2 0 0 2 2 2 1 Tetraspanin family BTB_2 PF02214.20 001261187.1_29626001_1 - 1.5e-20 73.2 0.0 2.6e-20 72.4 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.29 001261187.1_29626001_1 - 0.00054 20.0 0.0 0.00092 19.3 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Sushi PF00084.18 001257218.1_08022001_1 - 1.2e-05 25.7 10.1 0.024 15.1 2.2 2.6 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) DUF846 PF05832.10 001281865.1_08023001_3 - 5.8e-55 185.0 9.8 8.1e-55 184.5 9.8 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) DUF3169 PF11368.6 001281865.1_08023001_3 - 0.026 14.0 1.7 0.38 10.1 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) HXXEE PF13787.4 001281865.1_08023001_3 - 2.8 8.6 7.7 4.1 8.1 0.9 2.2 1 1 1 2 2 2 0 Protein of unknown function with HXXEE motif UPF0240 PF06784.9 001260754.1_29625001_1 - 1.3e-62 210.8 0.8 1.8e-62 210.3 0.8 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0240) Ras PF00071.20 001266792.2_29622001_1 - 2.7e-60 202.5 0.3 3.2e-60 202.3 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001266792.2_29622001_1 - 1.6e-33 115.3 0.6 2.3e-33 114.9 0.6 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001266792.2_29622001_1 - 1.9e-13 50.1 0.1 2.4e-13 49.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001266792.2_29622001_1 - 0.00013 21.3 0.0 0.0005 19.4 0.0 1.8 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 001266792.2_29622001_1 - 0.00032 20.6 0.0 0.0006 19.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001266792.2_29622001_1 - 0.00069 18.9 0.0 0.00089 18.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001266792.2_29622001_1 - 0.0012 18.3 0.1 0.003 17.0 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain DUF2757 PF10955.6 001266792.2_29622001_1 - 0.01 16.0 0.0 0.019 15.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) FeoB_N PF02421.16 001266792.2_29622001_1 - 0.071 12.5 0.0 4.9 6.5 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_24 PF13479.4 001266792.2_29622001_1 - 0.088 12.4 0.2 0.19 11.3 0.2 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.4 001266792.2_29622001_1 - 0.095 12.9 0.0 0.23 11.7 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain DUF258 PF03193.14 001266792.2_29622001_1 - 0.15 11.8 0.0 13 5.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF258 PCI PF01399.25 001287325.1_29524001_3 - 7.3e-21 74.5 0.4 7.3e-21 74.5 0.4 2.3 3 0 0 3 3 3 1 PCI domain TPR_12 PF13424.4 001287325.1_29524001_3 - 0.0013 18.9 12.7 0.021 15.0 2.9 4.7 3 2 3 6 6 6 1 Tetratricopeptide repeat DDRGK PF09756.7 001287325.1_29524001_3 - 0.0048 16.4 0.5 0.014 14.9 0.1 1.9 2 0 0 2 2 2 1 DDRGK domain DUF2153 PF09921.7 001287325.1_29524001_3 - 0.036 13.8 0.6 0.098 12.3 0.1 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2153) TPR_21 PF09976.7 001287325.1_29524001_3 - 0.056 13.1 2.6 0.066 12.8 0.9 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain DUF247 PF03140.13 001287325.1_29524001_3 - 0.069 12.4 0.0 0.16 11.2 0.0 1.7 1 0 0 1 1 1 0 Plant protein of unknown function TPR_2 PF07719.15 001287325.1_29524001_3 - 0.18 11.9 6.1 24 5.3 0.1 5.1 3 1 1 4 4 4 0 Tetratricopeptide repeat AAA_16 PF13191.4 001287325.1_29524001_3 - 1.3 9.2 4.8 0.59 10.4 1.8 1.9 2 1 0 2 2 2 0 AAA ATPase domain TPR_7 PF13176.4 001287325.1_29524001_3 - 5.7 7.1 6.5 8.6 6.5 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat ETS_PEA3_N PF04621.11 001280329.1_39724001_3 - 8e-137 456.6 28.8 8.5e-97 325.0 18.4 2.1 2 0 0 2 2 2 2 PEA3 subfamily ETS-domain transcription factor N terminal domain Ets PF00178.20 001280329.1_39724001_3 - 1.7e-38 130.8 0.2 2.8e-38 130.1 0.2 1.4 1 0 0 1 1 1 1 Ets-domain 3Beta_HSD PF01073.17 001285716.1_09023001_1 - 1.8e-112 374.8 0.0 2.2e-112 374.5 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 001285716.1_09023001_1 - 2.9e-22 79.2 0.0 4.3e-22 78.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.10 001285716.1_09023001_1 - 3e-16 59.2 0.6 2.2e-15 56.4 0.6 2.0 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.3 001285716.1_09023001_1 - 1.9e-15 57.0 0.0 2.3e-14 53.4 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.13 001285716.1_09023001_1 - 1.4e-11 43.9 0.0 2.1e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.4 001285716.1_09023001_1 - 3.6e-08 33.4 0.0 5.4e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.15 001285716.1_09023001_1 - 4.7e-06 25.8 0.0 5.9e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.8 001285716.1_09023001_1 - 0.00068 19.5 0.0 0.0013 18.5 0.0 1.4 1 0 0 1 1 1 1 KR domain NmrA PF05368.11 001285716.1_09023001_1 - 0.012 15.1 0.0 0.017 14.5 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family Sacchrp_dh_NADP PF03435.16 001285716.1_09023001_1 - 0.12 12.5 0.0 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Ldh_1_N PF00056.21 001285716.1_09023001_1 - 0.15 12.0 0.0 0.24 11.3 0.0 1.2 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain SCAN PF02023.15 001257455.1_29626001_2 - 6.4e-39 131.6 2.2 1.1e-38 130.8 2.2 1.4 1 0 0 1 1 1 1 SCAN domain zf-H2C2_2 PF13465.4 001257455.1_29626001_2 - 8.9e-39 130.1 56.7 3.6e-09 36.5 0.8 9.2 9 0 0 9 9 9 7 Zinc-finger double domain zf-C2H2 PF00096.24 001257455.1_29626001_2 - 5.6e-36 120.9 51.6 5.9e-08 32.6 0.7 7.7 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001257455.1_29626001_2 - 1.8e-14 53.1 60.6 0.00017 22.0 0.5 8.5 9 0 0 9 9 8 6 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001257455.1_29626001_2 - 4.9e-06 26.2 43.9 0.018 14.8 0.4 7.8 7 0 0 7 7 7 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001257455.1_29626001_2 - 3.2e-05 24.0 24.1 0.11 12.7 0.0 7.4 7 0 0 7 7 7 1 Zinc-finger double-stranded RNA-binding KRAB PF01352.25 001257455.1_29626001_2 - 0.00035 20.1 0.0 0.00075 19.0 0.0 1.4 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 001257455.1_29626001_2 - 0.0027 17.7 1.3 0.0027 17.7 1.3 5.4 5 1 1 6 6 5 2 Zinc ribbon domain FYDLN_acid PF09538.8 001257455.1_29626001_2 - 0.0037 17.8 7.9 3.1 8.4 0.9 4.4 1 1 1 3 3 3 1 Protein of unknown function (FYDLN_acid) zf-C2HC_2 PF13913.4 001257455.1_29626001_2 - 0.014 15.2 18.2 0.13 12.0 0.5 5.0 5 0 0 5 5 5 0 zinc-finger of a C2HC-type zinc_ribbon_9 PF14369.4 001257455.1_29626001_2 - 0.14 12.3 7.3 21 5.4 0.3 4.9 4 0 0 4 4 4 0 zinc-ribbon zf-met PF12874.5 001257455.1_29626001_2 - 0.55 10.6 31.7 1.1 9.6 0.3 7.0 6 0 0 6 6 6 0 Zinc-finger of C2H2 type zf-Di19 PF05605.10 001257455.1_29626001_2 - 0.9 9.7 25.0 0.77 10.0 0.3 4.9 3 1 1 5 5 4 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_15 PF17032.3 001257455.1_29626001_2 - 1.9 9.2 17.0 5.8 7.6 0.3 3.9 1 1 3 4 4 4 0 zinc-ribbon family zf-C2H2_11 PF16622.3 001257455.1_29626001_2 - 2 8.1 26.7 1.3 8.7 0.2 5.9 6 0 0 6 6 6 0 zinc-finger C2H2-type zf-LYAR PF08790.9 001257455.1_29626001_2 - 4.7 7.1 18.3 13 5.6 0.0 6.6 7 0 0 7 7 7 0 LYAR-type C2HC zinc finger Ras PF00071.20 001261148.2_29625001_3 - 1.3e-61 206.8 0.3 1.6e-61 206.5 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001261148.2_29625001_3 - 4.7e-34 117.1 0.0 7.7e-34 116.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001261148.2_29625001_3 - 2e-11 43.5 0.0 2.8e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001261148.2_29625001_3 - 0.00052 19.3 0.0 0.00072 18.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001261148.2_29625001_3 - 0.00081 19.3 0.0 0.0013 18.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001261148.2_29625001_3 - 0.028 14.2 0.8 1.8 8.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 RAWUL PF16207.3 001258171.1_29627001_2 - 1.2e-15 57.8 0.4 2.7e-15 56.6 0.4 1.7 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_2 PF13923.4 001258171.1_29627001_2 - 1.2e-10 40.9 8.1 1.2e-10 40.9 8.1 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001258171.1_29627001_2 - 2.3e-08 33.6 9.0 2.3e-08 33.6 9.0 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001258171.1_29627001_2 - 9.4e-07 28.9 8.0 9.4e-07 28.9 8.0 3.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.4 001258171.1_29627001_2 - 3.5e-05 23.4 8.5 3.5e-05 23.4 8.5 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001258171.1_29627001_2 - 4.6e-05 23.2 8.4 4.6e-05 23.2 8.4 2.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 001258171.1_29627001_2 - 0.0001 22.1 4.8 0.0006 19.6 4.8 2.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.5 001258171.1_29627001_2 - 0.00045 20.3 5.0 0.00045 20.3 5.0 2.5 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.4 001258171.1_29627001_2 - 0.0017 18.3 8.8 0.0017 18.3 8.8 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.6 001258171.1_29627001_2 - 0.092 12.5 3.3 0.26 11.0 3.3 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DUF3337 PF11816.6 001258171.1_29627001_2 - 0.1 12.3 0.1 0.21 11.2 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3337) Prok-RING_4 PF14447.4 001258171.1_29627001_2 - 0.39 10.5 16.9 0.11 12.2 8.8 3.4 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.3 001258171.1_29627001_2 - 2.6 8.1 10.8 0.49 10.4 6.2 2.2 2 0 0 2 2 2 0 zinc RING finger of MSL2 CD34_antigen PF06365.10 001267735.1_08023001_1 - 1.1e-70 237.4 0.0 1.6e-70 236.8 0.0 1.3 1 0 0 1 1 1 1 CD34/Podocalyxin family DUF4064 PF13273.4 001267735.1_08023001_1 - 0.011 16.0 0.6 0.027 14.7 0.0 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) PAP1 PF08601.8 001267735.1_08023001_1 - 8.7 5.8 19.4 3.2 7.2 13.7 2.0 2 0 0 2 2 2 0 Transcription factor PAP1 AKAP95 PF04988.10 001267024.1_29625001_3 - 2e-75 252.4 14.1 3.5e-75 251.6 14.1 1.4 1 0 0 1 1 1 1 A-kinase anchoring protein 95 (AKAP95) DUF678 PF05077.10 001267024.1_29625001_3 - 0.054 13.5 0.3 4 7.5 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF678) zf-C2H2_2 PF12756.5 001267024.1_29625001_3 - 0.48 10.6 12.7 3.7 7.8 1.0 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.10 001267024.1_29625001_3 - 9.7 6.4 9.8 4.5 7.5 0.7 2.7 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Ank_2 PF12796.5 001266441.1_29629001_2 - 5.7e-107 350.4 37.0 2.9e-15 56.5 0.3 10.0 2 2 8 10 10 10 9 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001266441.1_29629001_2 - 9.2e-100 325.7 19.0 2.5e-11 43.7 0.1 14.1 4 4 11 15 15 15 14 Ankyrin repeats (many copies) Ank PF00023.28 001266441.1_29629001_2 - 1.7e-79 258.9 39.9 5.7e-06 26.4 0.1 19.4 19 0 0 19 19 19 16 Ankyrin repeat Ank_5 PF13857.4 001266441.1_29629001_2 - 1.8e-76 250.7 42.4 2.3e-09 37.2 0.3 13.4 6 4 8 14 14 14 13 Ankyrin repeats (many copies) Ank_3 PF13606.4 001266441.1_29629001_2 - 8.5e-67 213.0 18.0 0.0002 21.4 0.0 18.7 19 0 0 19 19 19 12 Ankyrin repeat AAA_16 PF13191.4 001266441.1_29629001_2 - 0.0011 19.3 0.1 0.019 15.2 0.0 3.0 3 0 0 3 3 3 1 AAA ATPase domain NACHT PF05729.10 001266441.1_29629001_2 - 0.07 12.9 1.8 0.14 11.9 0.4 2.3 2 1 0 2 2 2 0 NACHT domain Cupin_3 PF05899.10 001266441.1_29629001_2 - 0.16 11.5 0.0 0.4 10.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF861) IHABP4_N PF16174.3 001266441.1_29629001_2 - 8.4 6.8 8.2 20 5.6 8.2 1.5 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal RRM_5 PF13893.4 001266000.1_29625001_2 - 1.6e-60 202.1 0.0 3e-50 168.9 0.0 3.3 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.20 001266000.1_29625001_2 - 2.3e-22 78.4 0.4 3.1e-08 33.2 0.0 4.3 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001266000.1_29625001_2 - 2.8e-07 30.2 0.0 0.21 11.3 0.0 3.2 3 0 0 3 3 3 3 Occluded RNA-recognition motif DUF4523 PF15023.4 001266000.1_29625001_2 - 0.00012 21.8 0.1 0.00047 19.9 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF4523) Dscam_C PF12355.6 001266000.1_29625001_2 - 0.00025 21.8 0.3 0.00068 20.5 0.3 1.7 1 0 0 1 1 1 1 Down syndrome cell adhesion molecule C terminal Limkain-b1 PF11608.6 001266000.1_29625001_2 - 0.00026 20.8 0.0 0.53 10.3 0.0 2.6 2 0 0 2 2 2 2 Limkain b1 RRM_3 PF08777.9 001266000.1_29625001_2 - 0.071 13.0 0.0 0.81 9.6 0.0 2.4 2 0 0 2 2 2 0 RNA binding motif zf-CCCH_2 PF14608.4 001266592.1_29625001_3 - 1.4e-16 60.1 58.3 5.8e-05 23.3 6.2 5.4 5 0 0 5 5 5 5 RNA-binding, Nab2-type zinc finger PWI PF01480.15 001266592.1_29625001_3 - 0.029 14.5 0.0 0.06 13.5 0.0 1.5 1 0 0 1 1 1 0 PWI domain zf-TAZ PF02135.14 001266592.1_29625001_3 - 1.4 9.3 18.4 0.26 11.6 2.3 2.4 2 0 0 2 2 2 0 TAZ zinc finger Parathyroid PF01279.15 001285753.1_09022001_1 - 4.9e-34 117.0 1.0 1.1e-33 115.9 1.0 1.6 1 0 0 1 1 1 1 Parathyroid hormone family Metallophos PF00149.26 001283722.1_29525001_2 - 3.4e-12 47.2 0.0 6e-12 46.4 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.5 001283722.1_29525001_2 - 0.0001 22.5 0.0 0.0023 18.0 0.0 2.2 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain PRELI PF04707.12 001261219.1_29623001_2 - 1.1e-57 194.1 0.1 1.5e-57 193.7 0.1 1.1 1 0 0 1 1 1 1 PRELI-like family YtxH PF12732.5 001261219.1_29623001_2 - 0.56 10.6 5.1 0.98 9.9 5.1 1.3 1 0 0 1 1 1 0 YtxH-like protein Calponin PF00402.16 001266075.1_29626001_1 - 0.3 10.6 2.1 0.32 10.5 0.5 1.9 2 0 0 2 2 2 0 Calponin family repeat Amidohydro_1 PF01979.18 001266075.1_29626001_3 - 5.8e-32 111.2 0.0 7.2e-32 110.9 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.9 001266075.1_29626001_3 - 1.5e-09 37.7 0.1 5.9e-07 29.2 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family UCH PF00443.27 001265896.2_29626001_3 - 3.3e-73 246.2 0.1 4.3e-73 245.8 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 001265896.2_29626001_3 - 1e-17 64.6 0.0 1.4e-17 64.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Cyt-b5 PF00173.26 001266273.1_29622001_1 - 3.2e-23 81.5 0.1 4.7e-23 81.0 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain tRNA-synt_2 PF00152.18 001257593.1_29625001_3 - 7.8e-81 271.4 0.2 1.1e-80 270.9 0.2 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.23 001257593.1_29625001_3 - 2.9e-14 52.7 0.0 9.5e-14 51.0 0.0 2.0 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.18 001257593.1_29625001_3 - 9.1e-07 28.5 0.1 0.017 14.5 0.1 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) RabGAP-TBC PF00566.16 001257435.1_29629001_3 - 5.9e-54 182.9 5.5 8.8e-54 182.3 5.5 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain MMADHC PF10229.7 001285614.1_09022001_1 - 5.8e-132 439.3 0.0 6.6e-132 439.1 0.0 1.0 1 0 0 1 1 1 1 Methylmalonic aciduria and homocystinuria type D protein zf-H2C2_2 PF13465.4 001257470.2_29626001_1 - 4.4e-72 235.4 84.0 2.3e-08 34.0 0.8 15.2 15 0 0 15 15 15 11 Zinc-finger double domain zf-C2H2 PF00096.24 001257470.2_29626001_1 - 9.4e-58 189.5 87.4 6.9e-06 26.1 0.5 13.5 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001257470.2_29626001_1 - 4.3e-46 151.4 88.4 0.00043 20.7 0.5 13.9 14 0 0 14 14 13 13 C2H2-type zinc finger BTB PF00651.29 001257470.2_29626001_1 - 2.4e-28 98.4 0.9 4.8e-28 97.5 0.9 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_11 PF16622.3 001257470.2_29626001_1 - 1.8e-19 69.0 53.5 1.7e-05 24.3 0.3 12.1 13 0 0 13 13 13 6 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 001257470.2_29626001_1 - 1.4e-17 63.3 50.4 0.0027 17.8 0.0 13.2 14 0 0 14 14 14 6 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 001257470.2_29626001_1 - 2.4e-11 43.5 60.2 0.22 11.8 1.0 12.6 12 0 0 12 12 12 6 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 001257470.2_29626001_1 - 1e-07 31.6 75.8 0.0012 18.7 0.1 12.9 13 0 0 13 13 13 6 C2H2-type zinc finger zf-H2C2_5 PF13909.4 001257470.2_29626001_1 - 6.2e-06 25.7 68.4 0.012 15.2 0.5 13.0 12 2 0 12 12 11 5 C2H2-type zinc-finger domain zinc_ribbon_15 PF17032.3 001257470.2_29626001_1 - 7.6e-06 26.5 37.9 0.16 12.6 1.2 7.4 5 2 2 7 7 7 4 zinc-ribbon family Zn-ribbon_8 PF09723.8 001257470.2_29626001_1 - 2.4e-05 24.2 59.6 0.31 11.0 4.5 9.7 5 3 5 10 10 10 4 Zinc ribbon domain zf-C2HC_2 PF13913.4 001257470.2_29626001_1 - 0.00025 20.7 41.1 0.25 11.2 0.1 9.7 10 0 0 10 10 9 4 zinc-finger of a C2HC-type zinc_ribbon_9 PF14369.4 001257470.2_29626001_1 - 0.0023 18.0 28.8 2 8.6 0.1 9.8 10 0 0 10 10 10 1 zinc-ribbon zf-Di19 PF05605.10 001257470.2_29626001_1 - 0.0028 17.7 49.9 0.0066 16.6 3.7 7.9 5 2 5 10 10 9 4 Drought induced 19 protein (Di19), zinc-binding zf-C2HE PF16278.3 001257470.2_29626001_1 - 0.0054 17.0 58.8 0.034 14.5 0.3 11.5 2 1 8 11 11 10 2 C2HE / C2H2 / C2HC zinc-binding finger Packaging_FI PF14000.4 001257470.2_29626001_1 - 0.013 15.8 0.5 0.013 15.8 0.5 2.1 2 0 0 2 2 1 0 DNA packaging protein FI zf-BED PF02892.13 001257470.2_29626001_1 - 0.023 14.6 55.9 0.28 11.1 0.9 9.9 3 2 7 10 10 10 0 BED zinc finger XPA_N PF01286.16 001257470.2_29626001_1 - 0.027 14.4 56.5 1.1 9.3 0.1 12.5 13 0 0 13 13 13 0 XPA protein N-terminal C1_1 PF00130.20 001257470.2_29626001_1 - 0.1 12.4 43.1 6.6 6.6 1.2 9.3 3 2 8 11 11 11 0 Phorbol esters/diacylglycerol binding domain (C1 domain) HypA PF01155.17 001257470.2_29626001_1 - 0.29 11.0 42.4 2.2 8.2 0.9 7.7 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF3268 PF11672.6 001257470.2_29626001_1 - 0.37 11.0 34.3 1.3 9.2 0.5 6.8 5 2 2 7 7 7 0 zinc-finger-containing domain zf-C2H2_9 PF16293.3 001257470.2_29626001_1 - 0.85 9.4 19.4 2 8.2 0.2 6.1 7 1 1 8 8 6 0 C2H2 type zinc-finger (1 copy) tRNA-synt_1f PF01921.16 001257470.2_29626001_1 - 1.4 7.7 3.1 1.3 7.8 0.1 2.4 3 1 0 3 3 3 0 tRNA synthetases class I (K) zf-C2H2_2 PF12756.5 001257470.2_29626001_1 - 6.7 7.0 51.8 4 7.7 7.6 9.8 2 1 8 10 10 9 0 C2H2 type zinc-finger (2 copies) Stanniocalcin PF03298.11 001261309.1_29625001_1 - 6e-101 335.7 8.6 7.7e-101 335.4 8.6 1.1 1 0 0 1 1 1 1 Stanniocalcin family WD40 PF00400.30 001267020.1_29623001_2 - 1e-08 35.6 2.2 0.015 16.0 0.0 5.0 4 1 1 5 5 5 3 WD domain, G-beta repeat CNH PF00780.20 001267020.1_29623001_2 - 2.8e-05 23.7 0.0 0.0016 18.0 0.0 2.2 2 0 0 2 2 2 2 CNH domain ANAPC4_WD40 PF12894.5 001267020.1_29623001_2 - 3.9e-05 23.7 0.0 1.7 8.9 0.0 3.6 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain EF-hand_2 PF09068.9 001266215.2_29629001_2 - 8.8e-36 122.6 0.5 2.3e-35 121.3 0.5 1.7 1 0 0 1 1 1 1 EF hand EF-hand_3 PF09069.9 001266215.2_29629001_2 - 6.2e-35 119.4 0.0 1.6e-34 118.0 0.0 1.8 1 0 0 1 1 1 1 EF-hand Spectrin PF00435.19 001266215.2_29629001_2 - 1.9e-10 41.0 20.4 2.8e-07 30.8 2.0 3.6 3 0 0 3 3 3 2 Spectrin repeat ZZ PF00569.15 001266215.2_29629001_2 - 2.7e-10 39.8 2.5 1.8e-09 37.1 2.7 2.2 2 0 0 2 2 2 1 Zinc finger, ZZ type WW PF00397.24 001266215.2_29629001_2 - 1.2e-07 31.4 1.2 3e-07 30.1 1.2 1.7 1 0 0 1 1 1 1 WW domain SOGA PF11365.6 001266215.2_29629001_2 - 0.0015 19.4 4.4 0.12 13.4 2.7 2.7 1 1 1 2 2 2 2 Protein SOGA Miff PF05644.9 001266215.2_29629001_2 - 0.002 17.7 2.4 0.0056 16.2 2.4 1.7 1 0 0 1 1 1 1 Mitochondrial and peroxisomal fission factor Mff DUF4600 PF15372.4 001266215.2_29629001_2 - 0.023 15.0 4.2 0.48 10.7 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4600) HAP1_N PF04849.11 001266215.2_29629001_2 - 0.061 12.4 6.2 1.1 8.3 2.1 2.7 2 0 0 2 2 2 0 HAP1 N-terminal conserved region HALZ PF02183.16 001266215.2_29629001_2 - 0.34 11.0 9.5 0.54 10.4 4.0 2.7 2 0 0 2 2 2 0 Homeobox associated leucine zipper EGF_CA PF07645.13 001261759.1_29628001_3 - 4.7e-28 97.0 64.2 2.6e-11 43.4 6.9 10.0 9 1 1 10 10 6 5 Calcium-binding EGF domain VWC PF00093.16 001261759.1_29628001_3 - 2.4e-18 66.0 63.6 5e-10 39.4 15.1 9.9 6 1 0 6 6 5 5 von Willebrand factor type C domain EGF_3 PF12947.5 001261759.1_29628001_3 - 5.2e-13 48.8 40.1 1e-08 35.1 15.7 10.1 10 0 0 10 10 7 4 EGF domain cEGF PF12662.5 001261759.1_29628001_3 - 2.3e-09 36.9 12.3 1.5e-07 31.0 3.3 10.1 11 0 0 11 11 10 5 Complement Clr-like EGF-like Laminin_G_2 PF02210.22 001261759.1_29628001_3 - 9.4e-08 32.6 0.1 1.8e-07 31.7 0.1 1.4 1 0 0 1 1 1 1 Laminin G domain EGF PF00008.25 001261759.1_29628001_3 - 9.7e-06 25.6 21.0 9.4e-05 22.5 8.4 11.1 10 1 0 10 10 6 6 EGF-like domain EGF_MSP1_1 PF12946.5 001261759.1_29628001_3 - 3e-05 23.8 9.2 3e-05 23.8 9.2 7.7 8 0 0 8 8 8 3 MSP1 EGF domain 1 Laminin_G_3 PF13385.4 001261759.1_29628001_3 - 0.00012 22.2 0.0 0.0002 21.4 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_1 PF00054.21 001261759.1_29628001_3 - 0.00023 21.2 0.0 0.00049 20.2 0.0 1.5 1 0 0 1 1 1 1 Laminin G domain TILa PF12714.5 001261759.1_29628001_3 - 0.00025 20.8 25.7 0.0014 18.4 9.6 10.4 8 4 2 10 10 7 4 TILa domain hEGF PF12661.5 001261759.1_29628001_3 - 0.00032 21.1 16.7 0.0024 18.4 6.0 11.8 11 0 0 11 11 10 4 Human growth factor-like EGF EGF_2 PF07974.11 001261759.1_29628001_3 - 0.0085 16.3 11.1 0.0085 16.3 11.1 12.2 13 2 0 13 13 8 1 EGF-like domain CFC PF09443.8 001261759.1_29628001_3 - 3 7.6 54.3 0.026 14.2 4.5 7.0 6 0 0 6 6 6 0 Cripto_Frl-1_Cryptic (CFC) DUF1640 PF07798.9 001260811.1_29623001_1 - 6.7e-57 192.2 21.4 1.7e-56 190.9 21.4 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1640) JAKMIP_CC3 PF16034.3 001260811.1_29623001_1 - 0.0012 18.7 10.0 0.0018 18.1 10.0 1.2 1 0 0 1 1 1 1 JAKMIP CC3 domain IZUMO PF15005.4 001260811.1_29623001_1 - 3.5 8.0 9.3 6.5 7.2 8.4 1.8 1 1 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated DUF972 PF06156.11 001260811.1_29623001_1 - 6.4 7.3 15.5 4.6 7.8 5.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF972) PBD PF00786.26 001257601.1_29628001_3 - 0.00025 21.2 0.2 0.00046 20.4 0.2 1.4 1 0 0 1 1 1 1 P21-Rho-binding domain adh_short PF00106.23 001257229.1_08023001_1 - 1.6e-39 135.2 0.0 2.2e-39 134.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001257229.1_08023001_1 - 1e-26 93.8 0.0 1.4e-26 93.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001257229.1_08023001_1 - 1.1e-07 31.8 0.0 1.6e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.19 001257229.1_08023001_1 - 0.059 12.7 0.0 0.15 11.4 0.0 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.6 001257229.1_08023001_1 - 0.18 11.5 0.5 0.87 9.3 0.1 2.2 3 0 0 3 3 3 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase GDP_Man_Dehyd PF16363.3 001257229.1_08023001_1 - 0.23 10.7 0.0 0.98 8.6 0.0 1.8 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase Myf5 PF12232.6 001278775.1_49822001_2 - 6.7e-26 90.7 13.2 6.7e-26 90.7 13.2 2.6 3 0 0 3 3 3 1 Myogenic determination factor 5 Basic PF01586.14 001278775.1_49822001_2 - 1.5e-22 80.5 1.1 3.5e-22 79.2 0.5 2.1 2 0 0 2 2 2 1 Myogenic Basic domain HLH PF00010.24 001278775.1_49822001_2 - 2.1e-15 56.2 4.0 7.4e-15 54.5 4.5 1.6 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain MHC_II_beta PF00969.17 001280698.1_39522001_3 - 4.7e-35 119.4 0.7 7.5e-35 118.8 0.7 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001280698.1_39522001_3 - 2.5e-24 85.4 0.2 6.6e-24 84.1 0.1 1.8 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001280698.1_39522001_3 - 0.00066 20.1 0.0 0.0018 18.7 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain MHC_I PF00129.16 001280698.1_39522001_3 - 0.013 15.0 0.7 0.023 14.1 0.7 1.4 1 0 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 DUF202 PF02656.13 001280698.1_39522001_3 - 0.042 14.1 0.0 0.082 13.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) ig PF00047.23 001280698.1_39522001_3 - 0.063 13.3 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain EF-hand_1 PF00036.30 001260801.1_29627001_3 - 2.4e-16 57.9 22.9 0.004 16.5 0.4 7.1 7 0 0 7 7 7 6 EF hand EF-hand_7 PF13499.4 001260801.1_29627001_3 - 2e-14 53.7 23.8 3.3e-06 27.4 0.6 4.3 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.4 001260801.1_29627001_3 - 1.2e-12 46.6 26.4 0.0043 16.4 0.0 6.7 6 0 0 6 6 6 5 EF hand EF-hand_6 PF13405.4 001260801.1_29627001_3 - 7.3e-12 44.1 16.8 0.023 14.5 0.0 6.9 7 0 0 7 7 7 6 EF-hand domain EF-hand_8 PF13833.4 001260801.1_29627001_3 - 4e-07 29.6 12.7 0.0035 17.0 0.0 4.6 5 0 0 5 5 5 2 EF-hand domain pair SPARC_Ca_bdg PF10591.7 001260801.1_29627001_3 - 0.52 10.5 16.1 6.4 7.0 0.2 4.1 2 2 1 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region Synaptobrevin PF00957.19 001257789.1_29622001_2 - 1.2e-31 108.3 1.7 1.5e-31 107.9 1.7 1.1 1 0 0 1 1 1 1 Synaptobrevin Ferlin_C PF16165.3 001257789.1_29622001_2 - 0.0021 17.9 0.2 0.004 17.0 0.2 1.5 1 0 0 1 1 1 1 Ferlin C-terminus DUF912 PF06024.10 001257789.1_29622001_2 - 0.014 15.5 0.3 0.021 15.0 0.3 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) MCU PF04678.11 001257789.1_29622001_2 - 0.024 14.6 0.0 0.032 14.2 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter TMCO5 PF14992.4 001257789.1_29622001_2 - 0.043 13.3 0.2 0.058 12.8 0.2 1.1 1 0 0 1 1 1 0 TMCO5 family Baculo_F PF12259.6 001257789.1_29622001_2 - 0.056 11.8 0.9 0.074 11.4 0.9 1.1 1 0 0 1 1 1 0 Baculovirus F protein Sec20 PF03908.11 001257789.1_29622001_2 - 0.073 12.9 0.1 0.073 12.9 0.1 1.6 2 0 0 2 2 1 0 Sec20 Prominin PF05478.9 001257789.1_29622001_2 - 0.098 10.5 1.7 0.24 9.2 1.9 1.5 1 1 0 1 1 1 0 Prominin EVI2A PF05399.9 001257789.1_29622001_2 - 0.11 12.0 0.1 0.16 11.4 0.1 1.3 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) DUF2207 PF09972.7 001257789.1_29622001_2 - 0.14 10.8 0.0 0.14 10.8 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) ODV-E18 PF10717.7 001257789.1_29622001_2 - 0.17 11.6 0.3 0.31 10.8 0.3 1.4 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Baculo_11_kDa PF06143.9 001257789.1_29622001_2 - 0.21 11.0 1.7 0.37 10.3 1.7 1.4 1 0 0 1 1 1 0 Baculovirus 11 kDa family Sigma_reg_N PF13800.4 001257789.1_29622001_2 - 0.56 10.4 4.0 0.94 9.7 4.0 1.3 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Glucosamine_iso PF01182.18 001257944.2_29623001_1 - 5.2e-18 65.6 0.0 7.9e-18 65.0 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Ras PF00071.20 001257551.1_29626001_2 - 1.3e-57 193.8 0.2 1.7e-57 193.4 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001257551.1_29626001_2 - 1.3e-31 109.2 0.1 1.9e-31 108.7 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001257551.1_29626001_2 - 8.2e-13 48.1 0.1 1.2e-12 47.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001257551.1_29626001_2 - 0.00091 18.7 0.0 0.01 15.3 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001257551.1_29626001_2 - 0.0019 18.1 0.0 0.0029 17.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001257551.1_29626001_2 - 0.021 14.1 0.0 0.029 13.6 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.8 001257551.1_29626001_2 - 0.056 12.7 0.0 0.094 12.0 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.7 001257551.1_29626001_2 - 0.15 11.7 0.0 0.28 10.8 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DUF258 PF03193.14 001257551.1_29626001_2 - 0.15 11.8 0.0 14 5.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 SASA PF03629.16 001261504.1_29625001_2 - 3.6e-15 56.1 0.0 6.5e-15 55.3 0.0 1.4 1 0 0 1 1 1 1 Carbohydrate esterase, sialic acid-specific acetylesterase Solute_trans_a PF03619.14 001260921.1_29625001_1 - 1.4e-103 345.9 21.2 2.1e-103 345.3 21.2 1.3 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Kinesin PF00225.21 001266387.1_29629001_2 - 9.1e-122 406.0 0.3 9.1e-122 406.0 0.3 1.9 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.3 001266387.1_29629001_2 - 2.5e-28 98.8 0.0 6.1e-28 97.5 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding Kinesin_assoc PF16183.3 001266387.1_29629001_2 - 0.048 13.7 0.1 0.048 13.7 0.1 2.7 2 0 0 2 2 2 0 Kinesin-associated AAA_16 PF13191.4 001266387.1_29629001_2 - 0.097 12.9 0.0 0.3 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain DUF948 PF06103.9 001266387.1_29629001_2 - 1.2 9.3 7.0 0.97 9.6 3.5 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) TPR_1 PF00515.26 001261251.1_29624001_1 - 6.5e-41 136.4 30.5 2.2e-06 27.1 0.0 9.1 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.15 001261251.1_29624001_1 - 6.1e-39 128.9 23.6 5.3e-06 26.0 1.6 9.6 9 0 0 9 9 9 7 Tetratricopeptide repeat DnaJ PF00226.29 001261251.1_29624001_1 - 6.1e-24 83.8 2.2 6.1e-24 83.8 2.2 2.6 3 0 0 3 3 2 1 DnaJ domain TPR_8 PF13181.4 001261251.1_29624001_1 - 1.7e-22 77.6 20.4 0.00032 20.5 0.4 8.9 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_11 PF13414.4 001261251.1_29624001_1 - 1.3e-16 59.8 26.9 7.4e-07 28.6 4.0 8.1 6 1 2 8 8 8 5 TPR repeat TPR_16 PF13432.4 001261251.1_29624001_1 - 1.4e-16 60.8 4.9 0.00063 20.3 0.0 5.8 4 2 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.4 001261251.1_29624001_1 - 1.6e-16 60.4 13.2 0.0066 16.8 0.2 6.4 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_17 PF13431.4 001261251.1_29624001_1 - 3.2e-16 58.3 15.5 9e-05 22.5 0.1 8.6 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_12 PF13424.4 001261251.1_29624001_1 - 4.9e-16 58.7 19.7 1.5e-05 25.0 1.0 6.6 4 2 2 6 6 6 5 Tetratricopeptide repeat TPR_14 PF13428.4 001261251.1_29624001_1 - 9.2e-11 41.5 9.3 0.53 11.1 0.0 8.5 7 2 3 10 10 8 2 Tetratricopeptide repeat TPR_9 PF13371.4 001261251.1_29624001_1 - 1.1e-09 38.1 7.0 0.21 11.7 0.1 5.5 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.4 001261251.1_29624001_1 - 1.4e-08 34.0 11.6 0.079 12.9 0.4 7.4 7 0 0 7 7 7 2 Tetratricopeptide repeat ANAPC3 PF12895.5 001261251.1_29624001_1 - 7.4e-07 29.2 28.5 0.0047 17.0 0.3 5.9 1 1 5 7 7 7 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.4 001261251.1_29624001_1 - 3.4e-05 23.5 17.6 0.55 10.1 0.4 6.5 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_6 PF13174.4 001261251.1_29624001_1 - 0.00014 22.1 23.1 0.13 12.8 0.8 7.4 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_4 PF07721.12 001261251.1_29624001_1 - 0.0053 17.1 0.4 3.8 8.3 0.0 3.4 3 0 0 3 3 2 1 Tetratricopeptide repeat RPT PF13446.4 001261251.1_29624001_1 - 0.047 13.5 0.0 0.25 11.2 0.0 2.3 1 0 0 1 1 1 0 A repeated domain in UCH-protein Sel1 PF08238.10 001261251.1_29624001_1 - 0.3 11.7 5.5 3 8.5 0.5 4.1 3 0 0 3 3 3 0 Sel1 repeat Alkyl_sulf_dimr PF14863.4 001261251.1_29624001_1 - 0.45 10.9 11.4 15 5.9 0.1 4.6 4 1 1 5 5 5 0 Alkyl sulfatase dimerisation RPN7 PF10602.7 001261251.1_29624001_1 - 0.53 9.8 14.4 0.22 11.0 4.0 3.0 2 1 0 2 2 2 0 26S proteasome subunit RPN7 MIT PF04212.16 001261251.1_29624001_1 - 1.2 9.1 27.5 0.47 10.4 1.3 6.1 4 2 1 5 5 5 0 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.7 001261251.1_29624001_1 - 3 7.3 6.3 12 5.3 0.1 4.5 4 1 1 5 5 5 0 SHNi-TPR Pkinase_Tyr PF07714.15 001260812.1_29627001_3 - 2.8e-61 206.9 0.0 4.2e-61 206.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001260812.1_29627001_3 - 3.9e-58 196.7 0.0 6.5e-58 196.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.21 001260812.1_29627001_3 - 0.22 11.3 4.9 3.6 7.3 0.1 3.0 4 0 0 4 4 4 0 Phosphotransferase enzyme family DUF4195 PF13836.4 001261022.1_29624001_2 - 2e-69 233.3 14.5 3.9e-69 232.3 14.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4195) zf-C2H2_6 PF13912.4 001261022.1_29624001_2 - 0.0021 17.9 0.2 0.0021 17.9 0.2 5.3 6 0 0 6 6 6 2 C2H2-type zinc finger zf-H2C2_2 PF13465.4 001261022.1_29624001_2 - 0.0022 18.3 2.3 0.0022 18.3 2.3 6.3 6 0 0 6 6 6 3 Zinc-finger double domain zf-met PF12874.5 001261022.1_29624001_2 - 0.0037 17.5 21.5 0.53 10.6 0.2 5.1 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.4 001261022.1_29624001_2 - 0.0042 17.7 56.1 0.0055 17.3 0.9 7.2 6 1 1 7 7 7 3 C2H2-type zinc finger zf-Di19 PF05605.10 001261022.1_29624001_2 - 0.011 15.9 4.2 0.011 15.9 4.2 4.6 3 2 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.6 001261022.1_29624001_2 - 0.059 13.6 0.5 0.059 13.6 0.5 5.7 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding Pkinase_Tyr PF07714.15 001285575.1_09024001_1 - 1.9e-37 128.8 0.0 2.5e-37 128.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001285575.1_09024001_1 - 1.7e-36 125.8 0.0 2.8e-36 125.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain TGF_beta_GS PF08515.10 001285575.1_09024001_1 - 3.3e-14 51.9 0.7 7.8e-14 50.7 0.7 1.7 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Activin_recp PF01064.21 001285575.1_09024001_1 - 4.1e-13 50.1 11.3 1e-12 48.8 11.3 1.7 1 0 0 1 1 1 1 Activin types I and II receptor domain FTA2 PF13095.4 001285575.1_09024001_1 - 0.0091 15.5 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 NARP1 PF12569.6 001266616.2_29627001_2 - 4e-219 728.6 23.3 4e-219 728.6 23.3 1.8 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_2 PF07719.15 001266616.2_29627001_2 - 1.9e-17 61.7 20.9 5.4e-05 22.9 0.1 8.4 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_8 PF13181.4 001266616.2_29627001_2 - 1.9e-14 52.4 22.0 0.00033 20.5 0.2 8.5 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.4 001266616.2_29627001_2 - 1e-12 47.6 7.4 0.11 13.3 0.0 9.8 9 2 2 11 11 9 2 Tetratricopeptide repeat TPR_1 PF00515.26 001266616.2_29627001_2 - 1.5e-12 46.7 26.2 2.5e-05 23.8 0.6 8.9 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.4 001266616.2_29627001_2 - 6.1e-11 41.7 2.8 1e-05 25.0 0.1 5.3 4 0 0 4 4 4 1 TPR repeat TPR_19 PF14559.4 001266616.2_29627001_2 - 1.6e-08 34.8 11.4 0.03 14.7 0.3 6.0 5 1 1 6 6 5 2 Tetratricopeptide repeat ANAPC3 PF12895.5 001266616.2_29627001_2 - 1.7e-08 34.4 16.8 0.00043 20.3 0.5 5.6 5 1 1 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.4 001266616.2_29627001_2 - 1.3e-07 32.1 4.3 0.17 12.5 0.1 5.7 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_12 PF13424.4 001266616.2_29627001_2 - 1.3e-06 28.5 14.4 1.5 9.0 0.1 7.7 5 3 1 6 6 6 3 Tetratricopeptide repeat TPR_15 PF13429.4 001266616.2_29627001_2 - 5.5e-06 25.7 1.6 5.5e-06 25.7 1.6 2.7 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.4 001266616.2_29627001_2 - 3.4e-05 23.4 11.0 0.035 14.0 0.1 7.4 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_17 PF13431.4 001266616.2_29627001_2 - 9.1e-05 22.5 5.9 0.29 11.5 0.0 6.6 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_9 PF13371.4 001266616.2_29627001_2 - 0.00013 21.9 1.2 0.72 9.9 0.2 4.5 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_21 PF09976.7 001266616.2_29627001_2 - 0.0075 15.9 0.1 0.28 10.8 0.0 3.1 2 1 0 2 2 2 1 Tetratricopeptide repeat-like domain Fis1_TPR_C PF14853.4 001266616.2_29627001_2 - 0.026 14.5 20.2 9.7 6.2 0.0 7.0 7 0 0 7 7 6 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.4 001266616.2_29627001_2 - 0.036 13.8 5.0 35 4.3 0.2 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF4252 PF14060.4 001266616.2_29627001_2 - 0.058 13.1 0.6 0.17 11.6 0.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4252) TPR_6 PF13174.4 001266616.2_29627001_2 - 0.17 12.5 11.2 49 4.7 0.1 6.4 7 1 0 7 7 5 0 Tetratricopeptide repeat DUF4746 PF15928.3 001266616.2_29627001_2 - 0.23 10.7 7.2 0.5 9.6 7.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TPR_3 PF07720.10 001266616.2_29627001_2 - 0.23 11.3 11.1 0.82 9.6 0.1 3.5 3 0 0 3 3 2 0 Tetratricopeptide repeat DUF789 PF05623.10 001266616.2_29627001_2 - 0.33 10.5 3.1 0.6 9.6 3.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF789) PPR PF01535.18 001266616.2_29627001_2 - 0.5 10.6 8.2 22 5.5 0.0 5.9 6 0 0 6 6 6 0 PPR repeat MIT PF04212.16 001266616.2_29627001_2 - 1.1 9.2 13.9 1.3 9.1 0.1 5.2 4 1 1 5 5 4 0 MIT (microtubule interacting and transport) domain Peptidase_S49_N PF08496.8 001266616.2_29627001_2 - 3 7.8 10.2 6.4 6.7 10.2 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal IL6 PF00489.15 001267771.1_08022001_2 - 3.1e-94 313.6 0.8 3.7e-94 313.4 0.8 1.0 1 0 0 1 1 1 1 Interleukin-6/G-CSF/MGF family IL23 PF16649.3 001267771.1_08022001_2 - 0.0013 18.7 0.2 0.0026 17.7 0.2 1.4 1 1 0 1 1 1 1 Interleukin 23 subunit alpha GCSF PF16647.3 001267771.1_08022001_2 - 0.0076 16.0 0.2 0.0098 15.6 0.2 1.2 1 0 0 1 1 1 1 Granulocyte colony-stimulating factor Ribosomal_S14 PF00253.19 001267537.1_29621001_2 - 9.1e-15 54.0 2.8 1.2e-14 53.6 2.8 1.2 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e MFS_5 PF05631.12 001260639.1_29624001_2 - 3.7e-80 269.4 6.3 5e-80 268.9 6.3 1.1 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_1 PF07690.14 001260639.1_29624001_2 - 5.1e-11 42.0 31.3 4.9e-10 38.7 28.6 2.7 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.14 001260639.1_29624001_2 - 0.00067 19.3 0.8 0.00067 19.3 0.8 2.9 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 Ldr_toxin PF13940.4 001260639.1_29624001_2 - 0.18 11.7 5.9 1.5 8.8 0.0 2.8 2 0 0 2 2 2 0 Toxin Ldr, type I toxin-antitoxin system MFS_1_like PF12832.5 001260639.1_29624001_2 - 4.5 5.9 13.0 0.092 11.4 1.5 3.0 2 1 1 3 3 3 0 MFS_1 like family MHC_II_beta PF00969.17 001267731.1_08022001_1 - 1.5e-39 133.9 1.0 2.2e-39 133.3 1.0 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001267731.1_08022001_1 - 1.6e-24 86.1 0.2 2.9e-24 85.2 0.2 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain ig PF00047.23 001267731.1_08022001_1 - 0.00013 22.0 0.0 0.00022 21.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 001267731.1_08022001_1 - 0.00019 21.9 0.4 0.0004 20.8 0.1 1.7 2 0 0 2 2 2 1 Immunoglobulin domain DUF202 PF02656.13 001267731.1_08022001_1 - 0.074 13.4 0.1 0.14 12.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Lep_receptor_Ig PF06328.9 001267766.1_08026001_1 - 1e-30 105.5 0.6 1e-30 105.5 0.6 2.9 4 0 0 4 4 4 1 Ig-like C2-type domain fn3 PF00041.19 001267766.1_08026001_1 - 7.4e-30 103.0 11.1 5.8e-11 42.5 0.3 5.9 6 0 0 6 6 6 4 Fibronectin type III domain EpoR_lig-bind PF09067.8 001267766.1_08026001_1 - 3.7e-07 30.2 0.3 1.3e-06 28.4 0.1 2.1 2 0 0 2 2 2 1 Erythropoietin receptor, ligand binding IL6Ra-bind PF09240.8 001267766.1_08026001_1 - 2.6e-06 27.6 1.4 4.5e-06 26.9 0.2 2.1 2 0 0 2 2 2 1 Interleukin-6 receptor alpha chain, binding Pur_ac_phosph_N PF16656.3 001267766.1_08026001_1 - 1.4e-05 25.4 14.3 0.0041 17.5 0.2 4.5 3 1 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 001267766.1_08026001_1 - 0.0011 19.1 0.0 0.89 9.8 0.0 2.8 2 0 0 2 2 2 2 Interferon-alpha/beta receptor, fibronectin type III fn3_2 PF16893.3 001267766.1_08026001_1 - 0.0013 18.7 0.1 0.014 15.3 0.0 2.8 4 0 0 4 4 4 1 Fibronectin type III domain Tissue_fac PF01108.15 001267766.1_08026001_1 - 5.2 6.8 11.8 1.4 8.7 0.1 4.7 5 1 0 5 5 5 0 Tissue factor BTB PF00651.29 001261623.1_29629001_3 - 1.2e-28 99.4 1.1 2.3e-28 98.5 1.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 001261623.1_29629001_3 - 4.4e-07 29.9 13.3 7.7e-07 29.2 2.8 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.24 001261623.1_29629001_3 - 0.014 15.7 2.4 0.014 15.7 2.4 3.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF3342 PF11822.6 001261623.1_29629001_3 - 0.029 14.4 0.2 0.055 13.5 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) zf-C2H2_4 PF13894.4 001261623.1_29629001_3 - 0.055 14.2 20.0 0.28 12.0 4.5 3.8 3 0 0 3 3 3 0 C2H2-type zinc finger MH2 PF03166.12 001266160.1_29628001_3 - 7e-79 264.2 0.1 1e-78 263.7 0.1 1.3 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.14 001266160.1_29628001_3 - 1.8e-43 146.8 2.7 3.4e-43 145.9 2.7 1.5 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.7 001266160.1_29628001_3 - 0.025 14.3 0.0 0.04 13.6 0.0 1.2 1 0 0 1 1 1 0 Interferon-regulatory factor 3 zf-RING_UBOX PF13445.4 001257655.1_29623001_3 - 0.00081 19.2 9.6 0.00081 19.2 9.6 2.8 3 1 0 3 3 3 1 RING-type zinc-finger Prok-RING_4 PF14447.4 001257655.1_29623001_3 - 0.0032 17.2 11.6 0.018 14.8 11.7 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 001257655.1_29623001_3 - 0.005 16.6 12.7 0.005 16.6 12.7 2.6 2 1 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 001257655.1_29623001_3 - 0.01 15.9 11.9 0.01 15.9 11.9 2.1 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4 PF00097.23 001257655.1_29623001_3 - 0.016 14.9 12.7 0.016 14.9 12.7 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.19 001257655.1_29623001_3 - 0.12 12.4 6.3 0.32 11.0 6.3 1.7 1 0 0 1 1 1 0 FYVE zinc finger Zn_Tnp_IS1595 PF12760.5 001257655.1_29623001_3 - 0.84 9.5 9.6 3.3 7.6 2.8 2.7 1 1 1 2 2 2 0 Transposase zinc-ribbon domain GcpE PF04551.12 001257655.1_29623001_3 - 0.91 8.4 5.2 3.7 6.4 5.2 1.8 1 1 0 1 1 1 0 GcpE protein Myelin_PLP PF01275.17 001265708.1_29624001_3 - 1.2e-100 336.2 21.3 1.5e-100 335.8 21.3 1.1 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) DUF373 PF04123.11 001265708.1_29624001_3 - 6.8 5.9 6.1 10 5.4 6.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) PAX PF00292.16 001266257.1_29629001_3 - 5.4e-71 236.2 0.8 8.4e-71 235.6 0.8 1.3 1 0 0 1 1 1 1 'Paired box' domain Homeobox PF00046.27 001266257.1_29629001_3 - 3.4e-22 77.9 4.5 6.4e-22 77.0 4.5 1.5 1 0 0 1 1 1 1 Homeobox domain HTH_23 PF13384.4 001266257.1_29629001_3 - 0.019 14.6 0.0 0.051 13.3 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain HTH_Tnp_IS1 PF12759.5 001266257.1_29629001_3 - 0.032 13.7 0.0 0.077 12.5 0.0 1.6 1 0 0 1 1 1 0 InsA C-terminal domain Bax1-I PF01027.18 001266529.1_29625001_2 - 5.5e-33 114.4 35.1 7e-33 114.1 35.1 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF2371 PF10177.7 001266529.1_29625001_2 - 0.086 12.9 0.5 0.15 12.1 0.5 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) GWT1 PF06423.10 001266529.1_29625001_2 - 0.66 10.0 0.0 0.66 10.0 0.0 2.4 2 0 0 2 2 2 0 GWT1 Nbs1_C PF08599.8 001265739.1_29625001_1 - 1.9e-33 114.3 0.1 1.9e-33 114.3 0.1 2.6 3 0 0 3 3 3 1 DNA damage repair protein Nbs1 NIBRIN_BRCT_II PF16508.3 001265739.1_29625001_1 - 5.7e-31 107.1 0.0 1.7e-30 105.6 0.0 1.9 1 0 0 1 1 1 1 Second BRCT domain on Nijmegen syndrome breakage protein FHA PF00498.24 001265739.1_29625001_1 - 6.9e-14 51.8 0.1 2.7e-13 49.9 0.1 2.1 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.3 001265739.1_29625001_1 - 4.6e-06 26.7 0.0 5.2e-05 23.4 0.0 2.7 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain RTT107_BRCT_5 PF16770.3 001265739.1_29625001_1 - 5.1e-06 26.2 0.0 2e-05 24.3 0.0 2.0 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT PF00533.24 001265739.1_29625001_1 - 0.0011 19.2 0.2 0.0086 16.3 0.0 2.5 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.5 001265739.1_29625001_1 - 0.0069 16.2 0.1 0.013 15.3 0.1 1.5 1 0 0 1 1 1 1 twin BRCT domain Thioredoxin PF00085.18 001266976.1_29627001_2 - 6.9e-90 295.7 0.2 5.5e-24 84.0 0.4 5.8 6 0 0 6 6 6 4 Thioredoxin DnaJ PF00226.29 001266976.1_29627001_2 - 2.3e-23 82.0 0.5 2.3e-23 82.0 0.5 2.0 2 0 0 2 2 2 1 DnaJ domain Thioredoxin_2 PF13098.4 001266976.1_29627001_2 - 2.8e-14 53.4 3.0 0.00023 21.5 0.0 6.0 4 3 0 4 4 4 3 Thioredoxin-like domain OST3_OST6 PF04756.11 001266976.1_29627001_2 - 1.5e-13 50.6 1.1 0.0031 16.8 0.1 4.3 3 1 1 4 4 4 3 OST3 / OST6 family, transporter family Thioredoxin_6 PF13848.4 001266976.1_29627001_2 - 6.5e-13 48.9 0.2 4.4e-05 23.4 0.0 4.3 4 1 0 4 4 4 3 Thioredoxin-like domain Thioredoxin_8 PF13905.4 001266976.1_29627001_2 - 1.6e-12 47.5 1.9 0.16 12.2 0.0 6.3 4 2 2 6 6 6 4 Thioredoxin-like Thioredoxin_7 PF13899.4 001266976.1_29627001_2 - 2.2e-07 30.8 2.6 1.6 8.8 0.0 4.6 4 0 0 4 4 4 3 Thioredoxin-like AhpC-TSA PF00578.19 001266976.1_29627001_2 - 2.8e-06 27.1 1.6 0.5 10.2 0.0 4.7 5 0 0 5 5 5 2 AhpC/TSA family Redoxin PF08534.8 001266976.1_29627001_2 - 5e-06 26.1 0.5 0.046 13.3 0.0 3.1 3 0 0 3 3 3 2 Redoxin TraF PF13728.4 001266976.1_29627001_2 - 0.012 15.3 0.7 0.9 9.2 0.0 3.4 4 0 0 4 4 4 0 F plasmid transfer operon protein Calsequestrin PF01216.15 001266976.1_29627001_2 - 0.14 11.1 0.0 2.2 7.1 0.0 2.4 2 0 0 2 2 2 0 Calsequestrin RMMBL PF07521.10 001266976.1_29627001_2 - 0.16 11.8 0.1 0.97 9.3 0.1 2.1 2 0 0 2 2 2 0 Zn-dependent metallo-hydrolase RNA specificity domain TPR_2 PF07719.15 001260880.1_29624001_3 - 1.3e-30 102.9 8.1 0.00099 18.9 0.3 8.7 9 0 0 9 9 8 6 Tetratricopeptide repeat TPR_1 PF00515.26 001260880.1_29624001_3 - 2.7e-27 93.3 10.6 9.5e-05 21.9 0.1 8.1 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_12 PF13424.4 001260880.1_29624001_3 - 1.8e-19 69.7 10.7 2.2e-06 27.7 0.7 6.0 4 1 2 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.4 001260880.1_29624001_3 - 2.1e-19 67.9 5.6 0.0025 17.8 0.1 6.3 7 0 0 7 7 5 5 Tetratricopeptide repeat TPR_14 PF13428.4 001260880.1_29624001_3 - 3.6e-19 67.7 7.7 0.025 15.3 0.0 8.9 5 2 4 9 9 9 4 Tetratricopeptide repeat TPR_7 PF13176.4 001260880.1_29624001_3 - 1.8e-15 55.6 11.5 0.0014 18.4 0.1 7.6 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_19 PF14559.4 001260880.1_29624001_3 - 9.6e-13 48.3 11.2 0.0047 17.3 0.0 6.0 4 2 3 7 7 6 4 Tetratricopeptide repeat TPR_16 PF13432.4 001260880.1_29624001_3 - 3.6e-11 43.4 4.9 0.0022 18.5 0.2 5.7 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.4 001260880.1_29624001_3 - 4.6e-11 42.2 7.4 0.0024 18.0 0.4 8.5 8 1 1 9 9 9 2 Tetratricopeptide repeat TPR_6 PF13174.4 001260880.1_29624001_3 - 3.9e-08 33.3 10.6 0.88 10.2 0.4 7.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_15 PF13429.4 001260880.1_29624001_3 - 2e-07 30.4 5.9 4.5e-06 25.9 0.6 2.5 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.5 001260880.1_29624001_3 - 1.6e-05 24.9 16.4 0.063 13.3 0.9 5.1 3 2 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.4 001260880.1_29624001_3 - 5.7e-05 22.6 8.5 4.7 6.8 0.1 5.5 3 1 2 5 5 5 2 TPR repeat TPR_9 PF13371.4 001260880.1_29624001_3 - 9.6e-05 22.3 2.7 0.068 13.2 0.1 4.6 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.4 001260880.1_29624001_3 - 0.0003 20.4 9.2 0.071 12.9 0.8 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat Coatomer_E PF04733.12 001260880.1_29624001_3 - 0.00082 18.7 6.0 0.025 13.9 0.4 2.9 1 1 2 3 3 3 2 Coatomer epsilon subunit NARP1 PF12569.6 001260880.1_29624001_3 - 0.017 13.9 5.0 0.82 8.3 0.0 3.1 2 1 1 3 3 3 0 NMDA receptor-regulated protein 1 PknG_TPR PF16918.3 001260880.1_29624001_3 - 0.023 13.3 0.2 0.049 12.2 0.0 1.6 2 0 0 2 2 2 0 Protein kinase G tetratricopeptide repeat DUF5112 PF17139.2 001260880.1_29624001_3 - 0.029 13.7 0.3 0.029 13.7 0.3 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF5112) PPR PF01535.18 001260880.1_29624001_3 - 0.24 11.6 2.7 28 5.1 0.2 4.8 6 0 0 6 6 6 0 PPR repeat Syntaxin_2 PF14523.4 001257724.1_29629001_3 - 4.4e-27 94.3 17.1 1.7e-26 92.4 10.0 2.2 2 0 0 2 2 2 2 Syntaxin-like protein SNARE PF05739.17 001257724.1_29629001_3 - 3.2e-18 65.3 2.2 6.3e-18 64.4 2.2 1.5 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.23 001257724.1_29629001_3 - 5.3e-10 39.2 11.8 9.3e-10 38.4 11.8 1.3 1 0 0 1 1 1 1 Syntaxin CCDC-167 PF15188.4 001257724.1_29629001_3 - 2 8.7 4.6 2.1 8.6 0.4 2.5 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 Synaptobrevin PF00957.19 001257724.1_29629001_3 - 7 6.4 8.8 0.72 9.6 1.8 2.4 2 0 0 2 2 2 0 Synaptobrevin DUF737 PF05300.9 001266664.1_29622001_3 - 2.4e-44 152.0 11.3 4.3e-44 151.2 11.3 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF737) CHCH PF06747.11 001266664.1_29622001_3 - 0.00086 19.3 0.1 0.0018 18.2 0.1 1.6 1 0 0 1 1 1 1 CHCH domain DUF3584 PF12128.6 001266664.1_29622001_3 - 0.16 9.3 5.6 0.2 9.0 5.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Jnk-SapK_ap_N PF09744.7 001266664.1_29622001_3 - 6.9 6.7 11.1 23 5.0 11.3 1.7 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 RRM_1 PF00076.20 001266335.1_29623001_2 - 5.2e-19 67.7 0.0 7.8e-19 67.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001266335.1_29623001_2 - 0.062 13.0 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.4 001266335.1_29623001_2 - 0.076 12.9 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif PA28_beta PF02252.16 001257629.1_29622001_1 - 4.5e-54 181.9 0.0 5.9e-54 181.5 0.0 1.2 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.16 001257629.1_29622001_1 - 9.8e-25 86.4 2.6 1.2e-24 86.1 0.5 2.1 2 0 0 2 2 2 1 Proteasome activator pa28 alpha subunit Rep_fac-A_3 PF08661.9 001266105.1_29622001_2 - 1.6e-31 108.6 0.0 2e-31 108.3 0.0 1.1 1 0 0 1 1 1 1 Replication factor A protein 3 adh_short PF00106.23 001260537.2_29624001_1 - 6e-40 136.6 0.0 8e-40 136.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001260537.2_29624001_1 - 2.5e-29 102.4 0.0 5.5e-29 101.3 0.0 1.4 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001260537.2_29624001_1 - 1.8e-18 66.9 0.0 2.8e-18 66.3 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.13 001260537.2_29624001_1 - 4.4e-07 29.2 0.1 6.1e-07 28.7 0.1 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Shikimate_DH PF01488.18 001260537.2_29624001_1 - 0.013 15.4 0.1 0.021 14.8 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.19 001260537.2_29624001_1 - 0.016 14.5 0.1 0.023 14.0 0.1 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.16 001260537.2_29624001_1 - 0.055 13.6 0.1 0.078 13.1 0.1 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Guanylate_kin PF00625.19 001266750.1_29622001_2 - 6.6e-70 234.4 0.0 7.8e-70 234.1 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.4 001266750.1_29622001_2 - 7.7e-07 29.2 0.4 7.3e-06 26.1 0.3 2.2 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.4 001266750.1_29622001_2 - 4.7e-06 27.0 0.0 1e-05 26.0 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 001266750.1_29622001_2 - 1.5e-05 25.3 1.6 6e-05 23.3 1.6 1.9 1 1 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.14 001266750.1_29622001_2 - 0.00057 19.7 0.1 0.0013 18.6 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 001266750.1_29622001_2 - 0.00062 19.7 0.0 0.0012 18.8 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.25 001266750.1_29622001_2 - 0.00065 20.1 0.1 0.00093 19.6 0.1 1.5 1 1 0 1 1 1 1 ABC transporter AAA_22 PF13401.4 001266750.1_29622001_2 - 0.00074 19.7 0.1 0.002 18.3 0.0 1.6 2 0 0 2 2 2 1 AAA domain cobW PF02492.17 001266750.1_29622001_2 - 0.0042 16.6 0.1 0.012 15.0 0.1 1.7 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.10 001266750.1_29622001_2 - 0.0047 16.7 0.1 0.018 14.8 0.0 1.8 2 0 0 2 2 2 1 NACHT domain AAA_29 PF13555.4 001266750.1_29622001_2 - 0.0055 16.3 0.1 0.0097 15.5 0.1 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_28 PF13521.4 001266750.1_29622001_2 - 0.011 15.9 0.0 0.022 14.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.4 001266750.1_29622001_2 - 0.011 15.3 0.1 0.12 11.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.4 001266750.1_29622001_2 - 0.017 14.7 0.0 0.52 9.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.10 001266750.1_29622001_2 - 0.027 13.6 0.1 0.052 12.7 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_14 PF13173.4 001266750.1_29622001_2 - 0.033 14.1 0.0 0.057 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.20 001266750.1_29622001_2 - 0.034 14.4 0.0 0.054 13.8 0.0 1.3 1 0 0 1 1 1 0 RNA helicase dNK PF01712.17 001266750.1_29622001_2 - 0.042 13.6 0.1 0.85 9.3 0.0 2.1 2 0 0 2 2 2 0 Deoxynucleoside kinase NTPase_1 PF03266.13 001266750.1_29622001_2 - 0.063 13.1 0.0 0.093 12.5 0.0 1.3 1 0 0 1 1 1 0 NTPase AAA_17 PF13207.4 001266750.1_29622001_2 - 0.079 13.3 0.1 0.75 10.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.7 001266750.1_29622001_2 - 0.08 12.0 0.1 1.2 8.1 0.1 2.0 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA PF00004.27 001266750.1_29622001_2 - 0.092 13.0 0.1 0.17 12.1 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.12 001266750.1_29622001_2 - 0.098 12.5 1.1 0.46 10.3 0.1 2.4 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) TsaE PF02367.15 001266750.1_29622001_2 - 0.12 12.2 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.16 001266750.1_29622001_2 - 0.14 11.9 0.0 0.23 11.2 0.0 1.6 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Dynamin_N PF00350.21 001266750.1_29622001_2 - 0.15 12.0 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Dynamin family Rad17 PF03215.13 001266750.1_29622001_2 - 0.19 10.5 0.0 0.25 10.1 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_25 PF13481.4 001266750.1_29622001_2 - 0.21 11.0 0.5 5.1 6.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain Roc PF08477.11 001266750.1_29622001_2 - 0.22 11.6 0.0 0.41 10.7 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.4 001266750.1_29622001_2 - 0.74 10.2 2.6 2.1 8.6 2.6 1.9 1 1 0 1 1 1 0 AAA domain T3SS_needle_E PF08988.8 001266750.1_29622001_2 - 1 9.5 3.5 11 6.1 1.3 2.5 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle Hist_deacetyl PF00850.17 001265655.1_29624001_3 - 3.7e-48 164.4 0.0 4.8e-48 164.1 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Arf PF00025.19 001257760.1_29623001_3 - 4.2e-54 182.5 0.1 5.4e-54 182.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.18 001257760.1_29623001_3 - 2.3e-12 46.6 2.7 4.3e-07 29.3 0.4 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.11 001257760.1_29623001_3 - 5.1e-12 46.0 0.0 7.4e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001257760.1_29623001_3 - 2.3e-10 40.2 0.0 2.9e-10 39.8 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.8 001257760.1_29623001_3 - 5e-10 39.0 0.1 7e-10 38.5 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 001257760.1_29623001_3 - 5.6e-06 26.3 0.0 8e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001257760.1_29623001_3 - 7.1e-06 25.4 0.1 9.4e-06 25.0 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.4 001257760.1_29623001_3 - 0.0057 16.8 0.1 0.11 12.7 0.1 2.1 1 1 0 1 1 1 1 AAA domain FeoB_N PF02421.16 001257760.1_29623001_3 - 0.029 13.8 0.1 0.057 12.8 0.0 1.4 1 1 0 1 1 1 0 Ferrous iron transport protein B GTP_EFTU PF00009.25 001257760.1_29623001_3 - 0.054 12.9 0.0 0.23 10.8 0.0 1.8 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_18 PF13238.4 001257760.1_29623001_3 - 0.066 13.6 0.0 0.1 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain LIM PF00412.20 001261048.1_29629001_2 - 1.3e-30 105.3 43.8 5.7e-14 51.9 5.3 3.8 4 0 0 4 4 4 3 LIM domain zf-dskA_traR PF01258.15 001261048.1_29629001_2 - 0.00019 21.1 1.4 0.00019 21.1 1.4 5.5 5 1 1 6 6 6 1 Prokaryotic dksA/traR C4-type zinc finger zf-CCCH PF00642.22 001257618.1_29623001_1 - 7.7e-19 67.0 34.8 3.3e-07 29.9 0.5 5.7 6 0 0 6 6 6 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.3 001257618.1_29623001_1 - 1.5e-10 41.1 19.3 1.2e-09 38.3 7.9 2.9 1 1 2 3 3 3 2 Zinc-finger containing family Torus PF16131.3 001257618.1_29623001_1 - 2e-08 34.8 29.3 0.0004 20.9 0.4 5.3 1 1 4 5 5 5 4 Torus domain zf-CCHC PF00098.21 001257618.1_29623001_1 - 3.5e-06 26.7 3.6 3.5e-06 26.7 3.6 2.9 2 0 0 2 2 2 1 Zinc knuckle zf-CCCH_2 PF14608.4 001257618.1_29623001_1 - 0.028 14.8 41.7 0.75 10.2 1.0 6.3 6 1 0 6 6 6 0 RNA-binding, Nab2-type zinc finger zf-C3H1 PF10650.7 001257618.1_29623001_1 - 0.041 13.5 12.5 1.4 8.6 0.2 4.4 4 0 0 4 4 4 0 Putative zinc-finger domain Homeobox PF00046.27 001265777.1_29629001_3 - 7.3e-33 112.0 14.3 2.2e-08 33.6 0.1 5.4 5 0 0 5 5 5 5 Homeobox domain Homez PF11569.6 001265777.1_29629001_3 - 4.4e-24 83.6 9.3 8.2e-15 53.9 1.0 4.9 5 0 0 5 5 5 3 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.9 001265777.1_29629001_3 - 1.1e-18 66.7 9.0 0.0023 17.7 0.1 5.7 5 0 0 5 5 5 5 Homeobox KN domain Sec16 PF12932.5 001265777.1_29629001_3 - 0.9 10.0 4.8 0.67 10.4 0.7 2.7 2 1 0 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region zf-H2C2_5 PF13909.4 001265777.1_29629001_3 - 2 8.1 10.7 2.8 7.7 2.8 3.1 3 0 0 3 3 3 0 C2H2-type zinc-finger domain TerB_C PF15615.4 001265777.1_29629001_3 - 2.7 8.1 11.9 1.4e+02 2.5 10.5 3.3 2 1 0 2 2 2 0 TerB-C domain SAM_1 PF00536.28 001260924.1_29625001_2 - 9.1e-09 35.5 0.0 1.5e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-C3HC4_4 PF15227.4 001260924.1_29625001_2 - 2.5e-08 33.8 12.2 4.4e-08 33.0 12.2 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001260924.1_29625001_2 - 7e-08 32.1 13.7 1.2e-07 31.3 13.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001260924.1_29625001_2 - 1.2e-07 31.3 13.3 2.2e-07 30.5 13.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001260924.1_29625001_2 - 4.6e-06 26.2 8.1 7.5e-06 25.6 8.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001260924.1_29625001_2 - 3e-05 24.0 14.8 6.6e-05 22.9 14.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.4 001260924.1_29625001_2 - 4e-05 23.4 13.0 9.3e-05 22.2 13.0 1.7 1 0 0 1 1 1 1 RING-type zinc-finger SAM_2 PF07647.15 001260924.1_29625001_2 - 0.00013 21.9 0.0 0.00023 21.1 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 001260924.1_29625001_2 - 0.0088 15.9 0.2 0.019 14.8 0.2 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain zf-ANAPC11 PF12861.5 001260924.1_29625001_2 - 0.024 14.5 4.5 0.056 13.4 4.5 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.3 001260924.1_29625001_2 - 0.04 13.9 6.3 0.069 13.2 6.3 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_5 PF14634.4 001260924.1_29625001_2 - 0.05 13.5 11.9 0.099 12.5 11.9 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-rbx1 PF12678.5 001260924.1_29625001_2 - 0.08 13.1 10.8 0.18 12.0 10.8 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.4 001260924.1_29625001_2 - 0.23 11.2 10.3 0.45 10.3 10.3 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-H2C2_2 PF13465.4 001260628.1_29625001_1 - 1.5e-60 198.9 71.8 1e-08 35.1 0.4 12.9 13 1 0 13 13 12 10 Zinc-finger double domain zf-C2H2 PF00096.24 001260628.1_29625001_1 - 9.2e-50 164.3 79.0 3.3e-06 27.1 0.6 13.1 13 0 0 13 13 13 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001260628.1_29625001_1 - 5.6e-28 95.1 80.0 0.0025 18.4 1.1 13.3 13 0 0 13 13 13 9 C2H2-type zinc finger KRAB PF01352.25 001260628.1_29625001_1 - 1.9e-21 75.3 1.2 3.5e-21 74.5 1.2 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 001260628.1_29625001_1 - 1e-12 47.5 63.7 0.0034 17.2 0.1 12.2 12 0 0 12 12 12 8 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001260628.1_29625001_1 - 3.1e-05 23.8 61.4 0.019 14.9 3.8 8.8 4 4 7 11 11 10 5 Zinc ribbon domain DZR PF12773.5 001260628.1_29625001_1 - 0.0002 21.2 46.8 56 3.7 0.3 7.7 2 1 0 2 2 1 0 Double zinc ribbon zinc_ribbon_15 PF17032.3 001260628.1_29625001_1 - 0.0017 18.9 39.4 0.14 12.8 0.5 6.8 2 2 8 10 10 10 6 zinc-ribbon family C1_4 PF07975.10 001260628.1_29625001_1 - 0.02 15.0 1.2 0.02 15.0 1.2 7.0 2 1 7 9 9 9 0 TFIIH C1-like domain zf-C2H2_11 PF16622.3 001260628.1_29625001_1 - 0.056 13.1 50.5 0.17 11.5 0.3 9.8 10 0 0 10 10 9 0 zinc-finger C2H2-type MamL-1 PF09596.8 001260628.1_29625001_1 - 0.13 12.4 0.8 43 4.3 0.0 3.2 3 0 0 3 3 3 0 MamL-1 domain Zn_ribbon_recom PF13408.4 001260628.1_29625001_1 - 0.9 10.0 44.2 0.61 10.5 1.6 8.1 3 2 6 9 9 9 0 Recombinase zinc beta ribbon domain zf-C2H2_jaz PF12171.6 001260628.1_29625001_1 - 1.9 8.8 0.0 0.28 11.4 0.2 9.3 10 0 0 10 10 8 0 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 001260628.1_29625001_1 - 5.6 7.2 28.9 4.6 7.5 0.4 6.0 4 2 1 6 6 6 0 zinc-finger-containing domain DNA_RNApol_7kD PF03604.11 001260628.1_29625001_1 - 7.4 6.2 44.2 11 5.6 0.1 10.6 11 0 0 11 11 11 0 DNA directed RNA polymerase, 7 kDa subunit XPA_N PF01286.16 001260628.1_29625001_1 - 8.5 6.4 56.4 1.6 8.7 0.2 11.1 12 0 0 12 12 12 0 XPA protein N-terminal Prefoldin PF02996.15 001261627.1_29622001_1 - 1.1e-28 99.4 3.4 1.6e-28 98.9 3.4 1.2 1 0 0 1 1 1 1 Prefoldin subunit ING PF12998.5 001261627.1_29622001_1 - 0.02 15.3 0.8 0.02 15.3 0.8 1.7 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding DUF1795 PF08786.9 001261627.1_29622001_1 - 0.067 13.1 0.1 0.067 13.1 0.1 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF1795) HR1 PF02185.14 001261627.1_29622001_1 - 0.11 12.5 2.7 1.3 9.0 0.0 2.9 2 1 1 3 3 3 0 Hr1 repeat KASH_CCD PF14662.4 001261627.1_29622001_1 - 0.16 11.6 6.9 0.33 10.7 0.3 2.1 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH UPF0693 PF16088.3 001261627.1_29622001_1 - 0.22 11.7 5.3 0.11 12.6 1.2 2.1 2 0 0 2 2 2 0 UPF0693 family DUF1640 PF07798.9 001261627.1_29622001_1 - 0.43 10.5 5.9 1.1 9.1 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) E2F_CC-MB PF16421.3 001261627.1_29622001_1 - 1.2 9.5 5.2 1.2 9.5 0.4 2.1 2 0 0 2 2 2 0 E2F transcription factor CC-MB domain CD20 PF04103.13 001261346.1_29627001_2 - 1.5e-27 96.5 16.9 2.1e-27 96.0 16.9 1.2 1 0 0 1 1 1 1 CD20-like family Ras PF00071.20 001285131.1_29524001_1 - 8.6e-54 181.4 0.0 1.1e-53 181.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001285131.1_29524001_1 - 2e-34 118.3 0.1 2.6e-34 117.9 0.1 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001285131.1_29524001_1 - 1.7e-11 43.7 0.0 2.5e-11 43.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001285131.1_29524001_1 - 1.6e-06 28.1 0.1 2.2e-06 27.6 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.4 001285131.1_29524001_1 - 0.00041 20.5 0.0 0.0029 17.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.14 001285131.1_29524001_1 - 0.011 15.6 0.1 0.059 13.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001285131.1_29524001_1 - 0.012 15.1 0.0 0.029 13.8 0.0 1.5 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.4 001285131.1_29524001_1 - 0.058 13.6 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.25 001285131.1_29524001_1 - 0.077 13.4 0.0 0.12 12.8 0.0 1.3 1 0 0 1 1 1 0 ABC transporter Gtr1_RagA PF04670.10 001285131.1_29524001_1 - 0.11 11.7 0.0 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region PduV-EutP PF10662.7 001285131.1_29524001_1 - 0.13 11.9 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Ras PF00071.20 001285131.1_29524001_2 - 0.056 12.9 0.0 0.076 12.5 0.0 1.1 1 0 0 1 1 1 0 Ras family Pkinase PF00069.23 001265666.1_29627001_3 - 2.6e-72 243.2 0.0 3.3e-72 242.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001265666.1_29627001_3 - 1.5e-28 99.7 0.0 2.2e-28 99.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 001265666.1_29627001_3 - 0.00069 18.9 0.2 0.0011 18.3 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family HAT_KAT11 PF08214.9 001266486.1_29629001_1 - 1.1e-70 238.5 0.3 1.9e-70 237.8 0.3 1.4 1 0 0 1 1 1 1 Histone acetylation protein KIX PF02172.14 001266486.1_29629001_1 - 2.4e-40 136.5 1.1 4.7e-40 135.6 1.1 1.5 1 0 0 1 1 1 1 KIX domain Creb_binding PF09030.8 001266486.1_29629001_1 - 4.3e-33 114.1 15.7 4.3e-33 114.1 15.7 12.0 10 3 2 12 12 12 1 Creb binding zf-TAZ PF02135.14 001266486.1_29629001_1 - 1.5e-28 98.9 73.1 4.6e-19 68.5 21.3 3.9 3 0 0 3 3 3 2 TAZ zinc finger DUF902 PF06001.11 001266486.1_29629001_1 - 6.8e-22 77.5 7.7 6.8e-22 77.5 7.7 2.6 2 0 0 2 2 2 1 Domain of Unknown Function (DUF902) Bromodomain PF00439.23 001266486.1_29629001_1 - 1.8e-16 59.8 0.1 4e-16 58.7 0.1 1.6 1 0 0 1 1 1 1 Bromodomain ZZ PF00569.15 001266486.1_29629001_1 - 7.4e-15 54.4 14.7 7.4e-15 54.4 14.7 3.4 4 0 0 4 4 4 1 Zinc finger, ZZ type KIX_2 PF16987.3 001266486.1_29629001_1 - 8.3e-05 22.4 0.4 0.00028 20.7 0.4 2.0 1 0 0 1 1 1 1 KIX domain Npa1 PF11707.6 001266486.1_29629001_1 - 0.00058 19.2 0.0 0.00097 18.5 0.0 1.3 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal EPL1 PF10513.7 001266486.1_29629001_1 - 10 6.4 16.7 1.2 9.4 0.7 3.2 3 0 0 3 3 3 0 Enhancer of polycomb-like Ribosomal_S18 PF01084.18 001257635.1_29623001_2 - 7.4e-16 58.0 0.0 1.1e-15 57.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S18 Cathelicidins PF00666.15 001285577.1_09022001_1 - 1.6e-50 169.5 0.4 1.9e-50 169.2 0.4 1.1 1 0 0 1 1 1 1 Cathelicidin Spp-24 PF07448.9 001285577.1_09022001_1 - 7.6e-05 22.7 0.5 0.00012 22.0 0.5 1.3 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Cystatin PF00031.19 001285577.1_09022001_1 - 0.00061 19.9 0.0 0.00076 19.6 0.0 1.2 1 0 0 1 1 1 1 Cystatin domain Aldo_ket_red PF00248.19 001310556.1_31323001_1 - 1.2e-60 205.1 0.0 1.4e-60 204.8 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Cadherin PF00028.15 001314293.1_09028001_1 - 6.8e-58 193.0 1.5 7.9e-19 67.8 0.0 5.4 6 0 0 6 6 6 4 Cadherin domain Cadherin_C PF01049.15 001314293.1_09028001_1 - 2.9e-05 24.2 0.0 0.00022 21.4 0.0 2.3 2 0 0 2 2 2 1 Cadherin cytoplasmic region Cadherin_3 PF16184.3 001314293.1_09028001_1 - 0.0028 17.5 0.1 0.067 13.1 0.1 2.9 3 0 0 3 3 3 1 Cadherin-like EGF PF00008.25 001314212.1_09023001_1 - 1.7e-21 76.0 72.0 3.6e-06 27.0 6.6 7.0 6 1 0 6 6 6 6 EGF-like domain hEGF PF12661.5 001314212.1_09023001_1 - 1.5e-13 50.7 72.9 0.00035 21.0 5.1 8.5 7 1 1 8 8 8 6 Human growth factor-like EGF EGF_2 PF07974.11 001314212.1_09023001_1 - 2e-09 37.5 92.1 0.00036 20.7 8.0 7.3 7 0 0 7 7 7 5 EGF-like domain EGF_MSP1_1 PF12946.5 001314212.1_09023001_1 - 0.012 15.6 2.5 0.012 15.6 2.5 5.8 6 0 0 6 6 6 0 MSP1 EGF domain 1 Laminin_EGF PF00053.22 001314212.1_09023001_1 - 5 7.2 60.3 0.071 13.1 9.3 5.8 2 2 3 5 5 5 0 Laminin EGF domain Mak10 PF04112.11 001194389.1_29626001_3 - 3.2e-35 121.0 2.2 3.6e-26 91.5 0.0 2.7 2 1 1 3 3 3 2 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase Rer1 PF03248.11 001194389.1_29626001_3 - 0.0031 17.1 0.5 0.006 16.2 0.5 1.4 1 0 0 1 1 1 1 Rer1 family Orn_Arg_deC_N PF02784.14 001291456.1_08029001_3 - 5.1e-64 215.9 0.2 6.5e-64 215.6 0.2 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001291456.1_08029001_3 - 1.8e-24 85.8 0.0 3.2e-24 85.0 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain DUF4506 PF14958.4 001194291.2_29625001_1 - 6.6e-59 197.3 0.2 1.1e-58 196.6 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4506) DUF4541 PF15074.4 001193716.1_29621001_1 - 2.5e-39 133.7 1.1 4.1e-39 132.9 1.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4541) Ras PF00071.20 001193860.1_29625001_1 - 5e-62 208.1 0.1 6.7e-62 207.7 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001193860.1_29625001_1 - 3.5e-32 111.0 0.0 6.6e-32 110.1 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001193860.1_29625001_1 - 3.4e-12 46.0 0.0 5.2e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001193860.1_29625001_1 - 0.00047 20.1 0.0 0.00078 19.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001193860.1_29625001_1 - 0.0023 17.2 0.0 0.0033 16.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001193860.1_29625001_1 - 0.0055 16.1 0.1 0.016 14.6 0.1 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001193860.1_29625001_1 - 0.012 15.4 0.0 1.3 8.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 DUF1467 PF07330.10 001193860.1_29625001_2 - 0.59 10.0 3.6 0.99 9.2 3.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1467) IZUMO PF15005.4 001194062.1_29622001_1 - 1.2e-29 103.6 0.2 1.7e-29 103.1 0.2 1.2 1 0 0 1 1 1 1 Izumo sperm-egg fusion, Ig domain-associated CLAG PF03805.11 001194062.1_29622001_1 - 0.036 11.5 0.6 0.046 11.2 0.6 1.0 1 0 0 1 1 1 0 Cytoadherence-linked asexual protein Integrin_alpha2 PF08441.10 001314316.1_09028001_3 - 6.5e-39 134.0 0.0 9.4e-39 133.4 0.0 1.2 1 0 0 1 1 1 1 Integrin alpha VWA PF00092.26 001314316.1_09028001_3 - 1.9e-30 106.3 2.1 2.8e-30 105.7 2.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain FG-GAP PF01839.21 001314316.1_09028001_3 - 3.8e-20 71.6 4.6 1.9e-07 31.0 0.2 3.7 3 0 0 3 3 3 3 FG-GAP repeat VWA_2 PF13519.4 001314316.1_09028001_3 - 1.7e-10 41.4 0.6 8.3e-09 35.9 0.1 2.4 2 0 0 2 2 2 1 von Willebrand factor type A domain VCBS PF13517.4 001314316.1_09028001_3 - 5.2e-07 30.0 0.5 0.00028 21.3 0.1 3.4 3 0 0 3 3 3 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.18 001314316.1_09028001_3 - 0.00013 21.6 0.4 0.00029 20.5 0.4 1.6 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region FG-GAP_2 PF14312.4 001314316.1_09028001_3 - 0.0096 16.0 7.9 0.53 10.5 0.0 4.1 5 0 0 5 5 5 2 FG-GAP repeat TUDOR PF00567.22 001194629.1_29629001_2 - 6.8e-84 277.8 7.1 3.8e-32 110.8 0.4 3.6 3 0 0 3 3 3 3 Tudor domain OST-HTH PF12872.5 001194629.1_29629001_2 - 2e-18 65.9 0.1 3.9e-10 39.4 0.0 4.3 4 1 0 4 4 4 3 OST-HTH/LOTUS domain Agenet PF05641.10 001194629.1_29629001_2 - 0.00051 20.3 0.3 0.23 11.8 0.1 3.0 2 0 0 2 2 2 2 Agenet domain IL8 PF00048.18 001322432.1_37923001_1 - 9.8e-21 73.6 2.2 1.7e-20 72.8 2.2 1.4 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Tmemb_185A PF10269.7 001193703.1_29622001_3 - 5e-13 49.2 4.3 7.6e-13 48.6 4.3 1.2 1 0 0 1 1 1 1 Transmembrane Fragile-X-F protein Ninjurin PF04923.10 001194415.1_29623001_2 - 2.6e-36 123.5 4.7 3.4e-36 123.2 4.7 1.1 1 0 0 1 1 1 1 Ninjurin zf-RING_UBOX PF13445.4 001318072.1_39524001_1 - 1.7e-12 47.0 3.5 1.7e-12 47.0 3.5 2.8 2 1 1 3 3 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 001318072.1_39524001_1 - 1.1e-11 44.5 7.9 1.1e-11 44.5 7.9 2.6 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001318072.1_39524001_1 - 9.9e-10 38.0 8.1 3.2e-09 36.4 8.1 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001318072.1_39524001_1 - 2.7e-09 36.9 2.9 2.7e-09 36.9 2.9 3.0 2 1 0 2 2 2 1 B-box zinc finger zf-RING_2 PF13639.4 001318072.1_39524001_1 - 7.5e-08 32.4 7.2 7.5e-08 32.4 7.2 2.2 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 001318072.1_39524001_1 - 1.5e-07 31.0 9.4 9.9e-07 28.4 9.5 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001318072.1_39524001_1 - 4.3e-07 29.6 5.0 4.3e-07 29.6 5.0 2.5 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001318072.1_39524001_1 - 2e-06 27.5 6.4 2e-06 27.5 6.4 2.6 2 0 0 2 2 2 1 zinc-RING finger domain SPRY PF00622.26 001318072.1_39524001_1 - 2.3e-06 27.6 0.1 5.1e-06 26.5 0.1 1.6 1 0 0 1 1 1 1 SPRY domain U-box PF04564.13 001318072.1_39524001_1 - 0.00027 20.9 0.0 0.00078 19.4 0.0 1.8 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.6 001318072.1_39524001_1 - 0.0099 15.6 4.6 0.026 14.2 4.6 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit DUF3835 PF12927.5 001318072.1_39524001_1 - 0.031 15.0 1.8 0.13 13.0 0.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3835) Bacillus_HBL PF05791.9 001318072.1_39524001_1 - 0.14 11.8 2.0 0.22 11.1 2.0 1.3 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) Prok-RING_4 PF14447.4 001318072.1_39524001_1 - 0.3 10.8 15.9 0.12 12.1 10.3 3.1 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.4 001318072.1_39524001_1 - 0.3 10.7 6.5 4.1 7.1 6.9 2.8 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.4 001318072.1_39524001_1 - 0.46 10.3 8.8 0.28 11.0 4.6 2.7 3 1 0 3 3 2 0 zf-RING of BARD1-type protein zf-RING_11 PF17123.3 001318072.1_39524001_1 - 0.79 9.4 5.8 2.3 7.9 3.7 2.8 2 1 0 2 2 2 0 RING-like zinc finger OmpH PF03938.12 001318072.1_39524001_1 - 1.2 8.9 7.2 2.2 8.1 7.2 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Uso1_p115_C PF04871.11 001318072.1_39524001_1 - 1.4 9.2 10.5 1.2 9.4 8.9 1.6 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region zf-RING_10 PF16685.3 001318072.1_39524001_1 - 1.5 8.9 12.5 0.087 12.8 5.3 2.7 1 1 1 2 2 2 0 zinc RING finger of MSL2 FYVE PF01363.19 001318072.1_39524001_1 - 5.5 7.1 9.0 1.6 8.8 2.0 2.9 2 0 0 2 2 2 0 FYVE zinc finger zf-rbx1 PF12678.5 001318072.1_39524001_1 - 9.3 6.5 13.0 1 9.6 7.2 2.5 2 1 0 2 2 1 0 RING-H2 zinc finger domain Acetyltransf_1 PF00583.23 001193901.2_29622001_2 - 2.1e-15 56.8 0.0 3.1e-15 56.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.5 001193901.2_29622001_2 - 1.5e-10 41.0 0.1 3.1e-10 39.9 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.5 001193901.2_29622001_2 - 2.2e-08 34.3 0.0 3.6e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.8 001193901.2_29622001_2 - 1.5e-07 31.1 0.0 2.8e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.5 001193901.2_29622001_2 - 0.0017 18.3 0.1 0.0037 17.2 0.1 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.3 001193901.2_29622001_2 - 0.0027 17.0 0.0 0.0045 16.4 0.0 1.3 1 0 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_13 PF13880.4 001193901.2_29622001_2 - 0.0049 16.7 0.1 0.0093 15.8 0.1 1.4 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase Acetyltransf_3 PF13302.5 001193901.2_29622001_2 - 0.0058 17.2 0.0 0.013 16.0 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain V-set PF07686.15 001302667.1_08022001_1 - 5.1e-07 29.7 0.0 1.6e-06 28.1 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001302667.1_08022001_1 - 7.9e-07 29.5 0.3 0.01 16.3 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001302667.1_08022001_1 - 3.4e-05 24.0 0.4 0.29 11.4 0.2 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001302667.1_08022001_1 - 0.00019 21.4 0.4 0.85 9.7 0.0 2.9 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001302667.1_08022001_1 - 0.012 15.6 0.0 0.33 10.9 0.0 2.5 2 1 0 2 2 2 0 Immunoglobulin I-set domain DUF4320 PF14208.4 001302667.1_08022001_1 - 0.075 13.0 0.1 0.84 9.6 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4320) Macro PF01661.19 001194725.1_29623001_2 - 9.7e-06 25.5 0.0 1.5e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Macro domain TLV_coat PF00429.17 001305593.1_37924001_1 - 5e-131 438.0 0.6 7.4e-131 437.4 0.6 1.2 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) Trimer_CC PF08954.9 001305593.1_37924001_1 - 0.31 10.5 1.2 0.62 9.5 1.2 1.4 1 0 0 1 1 1 0 Trimerisation motif LPP PF04728.11 001305593.1_37924001_1 - 0.89 9.9 2.6 1.3 9.3 1.3 1.9 2 0 0 2 2 2 0 Lipoprotein leucine-zipper SPRY PF00622.26 001290251.1_22424001_1 - 7.5e-13 48.5 0.4 1.3e-12 47.8 0.4 1.4 1 0 0 1 1 1 1 SPRY domain PRY PF13765.4 001290251.1_22424001_1 - 1.9e-10 40.0 0.0 4.4e-10 38.9 0.0 1.7 1 0 0 1 1 1 1 SPRY-associated domain zf-C3HC4_4 PF15227.4 001290251.1_22424001_1 - 2.9e-09 36.8 11.6 2.9e-09 36.8 11.6 3.9 4 1 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 001290251.1_22424001_1 - 7.6e-09 35.3 10.0 7.6e-09 35.3 10.0 3.6 3 1 0 3 3 2 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001290251.1_22424001_1 - 9.4e-09 34.9 9.4 9.4e-09 34.9 9.4 4.5 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001290251.1_22424001_1 - 3.1e-08 33.2 10.3 3.1e-08 33.2 10.3 3.9 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001290251.1_22424001_1 - 7.4e-08 32.0 5.8 7.4e-08 32.0 5.8 4.0 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001290251.1_22424001_1 - 1e-07 31.9 10.1 1e-07 31.9 10.1 4.5 4 1 0 4 4 4 1 Ring finger domain zf-RING_5 PF14634.4 001290251.1_22424001_1 - 1.2e-07 31.4 7.6 1.2e-07 31.4 7.6 4.6 4 1 0 4 4 3 1 zinc-RING finger domain Prok-RING_4 PF14447.4 001290251.1_22424001_1 - 0.00045 19.9 8.0 0.00045 19.9 8.0 3.4 3 0 0 3 3 2 1 Prokaryotic RING finger family 4 zf-B_box PF00643.22 001290251.1_22424001_1 - 0.0052 16.8 7.5 0.0052 16.8 7.5 4.4 4 1 0 4 4 4 1 B-box zinc finger Fes1 PF08609.8 001290251.1_22424001_1 - 0.054 14.3 2.1 7.8 7.3 0.8 2.6 2 1 0 2 2 2 0 Nucleotide exchange factor Fes1 KAR9 PF08580.8 001290251.1_22424001_1 - 0.11 10.8 3.5 0.2 10.1 3.5 1.3 1 0 0 1 1 1 0 Yeast cortical protein KAR9 UPF0231 PF06062.9 001290251.1_22424001_1 - 0.42 10.8 3.2 1 9.5 0.4 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0231) Ald_Xan_dh_C2 PF02738.16 001308444.1_08029001_1 - 5.1e-181 602.7 0.1 6.3e-181 602.4 0.1 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 001308444.1_08029001_1 - 9.5e-44 149.0 0.0 2e-43 147.9 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.20 001308444.1_08029001_1 - 1.7e-32 111.9 0.1 3.4e-32 111.0 0.1 1.5 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.18 001308444.1_08029001_1 - 6e-31 106.1 0.8 1.8e-30 104.6 0.8 1.9 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.15 001308444.1_08029001_1 - 1.9e-26 92.1 0.0 5.4e-26 90.6 0.0 1.8 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.25 001308444.1_08029001_1 - 2.9e-09 36.6 3.8 6.5e-09 35.5 0.1 2.9 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain 7tm_1 PF00001.19 001302791.1_08025001_2 - 1.4e-44 152.2 23.2 2e-44 151.7 23.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001302791.1_08025001_2 - 3.1e-13 50.0 21.3 4.5e-13 49.4 21.3 1.1 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001302791.1_08025001_2 - 1.5e-11 44.1 25.5 2.3e-11 43.4 25.5 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF2340 PF10209.7 001193706.1_29622001_1 - 3.6e-42 143.5 0.1 4.4e-42 143.2 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) Orn_Arg_deC_N PF02784.14 001291506.1_39528001_1 - 2.3e-63 213.8 0.1 3e-63 213.4 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001291506.1_39528001_1 - 1e-23 83.4 0.0 1.7e-23 82.7 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain DUF4939 PF16297.3 001302557.1_08029001_1 - 3.7e-15 55.7 0.0 6.5e-15 54.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Retrotrans_gag PF03732.15 001302557.1_08029001_1 - 4.9e-15 55.5 1.9 1.8e-14 53.6 0.0 2.3 2 0 0 2 2 2 1 Retrotransposon gag protein Rootletin PF15035.4 001302557.1_08029001_1 - 0.00029 20.8 0.1 0.00056 19.9 0.1 1.4 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion KASH_CCD PF14662.4 001302557.1_08029001_1 - 0.002 17.9 4.6 0.0034 17.1 4.6 1.3 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH zf-CCHC_5 PF14787.4 001302557.1_08029001_1 - 0.0027 17.3 0.2 0.0064 16.1 0.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger Spc29 PF17082.3 001302557.1_08029001_1 - 0.0075 16.0 0.5 0.012 15.3 0.5 1.2 1 0 0 1 1 1 1 Spindle Pole Component 29 CCDC106 PF15794.3 001302557.1_08029001_1 - 0.26 10.8 4.2 0.81 9.2 2.3 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 SlyX PF04102.10 001302557.1_08029001_1 - 0.34 11.4 2.4 0.82 10.2 2.4 1.7 1 0 0 1 1 1 0 SlyX bZIP_1 PF00170.19 001302557.1_08029001_1 - 0.36 10.8 4.8 1.1 9.3 4.8 1.8 1 0 0 1 1 1 0 bZIP transcription factor CENP-H PF05837.10 001302557.1_08029001_1 - 0.39 11.0 4.7 0.84 9.9 4.7 1.5 1 0 0 1 1 1 0 Centromere protein H (CENP-H) ZapB PF06005.10 001302557.1_08029001_1 - 0.62 10.4 9.7 1.4 9.3 9.7 1.5 1 0 0 1 1 1 0 Cell division protein ZapB DUF972 PF06156.11 001302557.1_08029001_1 - 0.73 10.4 3.9 1.9 9.0 3.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF972) DivIC PF04977.13 001302557.1_08029001_1 - 3.6 7.3 7.1 8.6 6.1 7.1 1.6 1 0 0 1 1 1 0 Septum formation initiator GIT_CC PF16559.3 001302557.1_08029001_1 - 4.4 7.3 7.8 16 5.5 7.8 2.0 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor CAP_N PF01213.17 001302557.1_08029001_1 - 7.1 5.9 9.4 13 5.0 9.4 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal SHE3 PF17078.3 001302557.1_08029001_1 - 8 6.0 10.2 2.1 7.8 7.1 1.5 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 Asp_protease_2 PF13650.4 001302557.1_08029001_3 - 0.00078 20.0 0.0 0.0012 19.3 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001302557.1_08029001_3 - 0.016 15.1 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001302557.1_08029001_3 - 0.052 14.0 0.0 0.085 13.3 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease ODC_AZ PF02100.15 001289597.2_08023001_3 - 6.9e-20 71.0 0.0 1.1e-19 70.3 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme FGF PF00167.16 001291973.1_09022001_1 - 2.9e-43 146.8 0.1 3.9e-43 146.4 0.1 1.1 1 0 0 1 1 1 1 Fibroblast growth factor SR-25 PF10500.7 001291973.1_09022001_1 - 0.76 9.2 10.1 1.4 8.4 10.1 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RAP1 PF07218.9 001291973.1_09022001_1 - 7.7 4.5 6.1 9.9 4.2 6.1 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF1180 PF06679.10 001291973.1_09022001_1 - 7.9 6.7 5.9 0.55 10.5 1.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) PRIMA1 PF16101.3 001291973.1_09022001_2 - 0.52 10.2 3.3 1.1 9.2 3.3 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 NTR PF01759.19 001190961.1_29621001_1 - 0.024 14.3 0.0 0.026 14.2 0.0 1.3 1 1 0 1 1 1 0 UNC-6/NTR/C345C module Sugar_tr PF00083.22 001314215.1_09025001_2 - 2.3e-97 326.6 30.9 3.2e-71 240.4 19.4 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.14 001314215.1_09025001_2 - 4.9e-33 114.4 26.4 8.8e-27 93.8 21.4 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.11 001314215.1_09025001_2 - 0.0004 18.8 5.0 0.0004 18.8 5.0 2.5 3 0 0 3 3 3 1 Fungal trichothecene efflux pump (TRI12) Phage_holin_2_3 PF16080.3 001314215.1_09025001_2 - 0.017 14.7 1.3 0.44 10.2 0.0 3.1 2 0 0 2 2 2 0 Bacteriophage holin family HP1 SPRY PF00622.26 001194675.1_29625001_1 - 1.8e-06 28.0 0.0 3.2e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 SPRY domain PRY PF13765.4 001194675.1_29625001_1 - 7e-05 22.2 0.0 0.00015 21.2 0.0 1.6 1 0 0 1 1 1 1 SPRY-associated domain Aldo_ket_red PF00248.19 001310569.1_31323001_1 - 1.5e-57 194.9 0.0 1.7e-57 194.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Sacchrp_dh_NADP PF03435.16 001310569.1_31323001_1 - 0.1 12.7 0.0 5.9 7.0 0.0 2.2 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Sugar_tr PF00083.22 001314227.1_09024001_3 - 4.4e-152 506.9 16.3 5.2e-152 506.7 16.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001314227.1_09024001_3 - 1.9e-16 59.8 39.9 1.2e-15 57.1 30.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_2_3 PF16080.3 001314227.1_09024001_3 - 0.019 14.6 0.2 0.09 12.4 0.2 2.2 1 0 0 1 1 1 0 Bacteriophage holin family HP1 ODC_AZ PF02100.15 001290218.1_08022001_2 - 4.6e-15 55.5 0.0 7.1e-15 54.9 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme SIR2 PF02146.15 001314319.1_09025001_3 - 3.8e-62 209.2 0.0 6.4e-62 208.5 0.0 1.4 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.20 001314319.1_09025001_3 - 0.0065 16.1 0.0 4.1 7.0 0.0 2.4 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain DUF592 PF04574.11 001314319.1_09025001_3 - 0.0069 16.0 0.2 0.013 15.1 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF592) Peptidase_M28 PF04389.15 001301847.1_08025001_1 - 6.9e-13 48.6 0.0 1.1e-12 47.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.20 001301847.1_08025001_1 - 1.2e-10 41.2 0.0 3.2e-10 39.8 0.0 1.8 1 1 0 1 1 1 1 PA domain TFR_dimer PF04253.13 001301847.1_08025001_1 - 3.7e-09 36.6 0.8 1.1e-07 31.9 0.1 2.6 2 0 0 2 2 2 1 Transferrin receptor-like dimerisation domain DUF3855 PF12967.5 001301847.1_08025001_1 - 0.11 12.3 0.1 0.27 11.0 0.1 1.6 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3855) Kunitz_BPTI PF00014.21 001320165.1_39724001_1 - 1.8e-34 117.6 20.3 2.6e-18 65.9 4.0 2.4 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Hydrolase_4 PF12146.6 001190904.1_29623001_3 - 1.5e-15 57.0 0.0 1.6e-09 37.3 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.18 001190904.1_29623001_3 - 3.8e-14 52.8 0.0 1.6e-08 34.4 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold AXE1 PF05448.10 001190904.1_29623001_3 - 2.7e-08 32.7 0.0 0.00016 20.3 0.0 3.0 2 1 1 3 3 3 2 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.5 001190904.1_29623001_3 - 6.5e-06 26.8 0.1 4.4e-05 24.1 0.0 2.3 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.14 001190904.1_29623001_3 - 0.00012 21.9 0.0 0.0064 16.2 0.0 2.7 2 1 1 3 3 3 1 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.11 001190904.1_29623001_3 - 0.00087 19.1 0.0 0.0012 18.6 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold BAAT_C PF08840.9 001190904.1_29623001_3 - 0.0026 17.6 0.0 0.012 15.4 0.0 1.9 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.11 001190904.1_29623001_3 - 0.0032 17.0 0.0 0.0045 16.5 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.19 001190904.1_29623001_3 - 0.0057 16.0 0.0 0.0079 15.6 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.16 001190904.1_29623001_3 - 0.0059 16.1 0.0 0.1 12.0 0.0 2.3 3 0 0 3 3 3 1 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.16 001190904.1_29623001_3 - 0.028 13.8 0.0 0.14 11.6 0.0 1.9 1 1 0 1 1 1 0 Dienelactone hydrolase family Esterase PF00756.18 001190904.1_29623001_3 - 0.085 12.4 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Putative esterase Abhydrolase_5 PF12695.5 001190904.1_29623001_3 - 0.11 12.1 0.0 0.33 10.5 0.0 1.7 1 1 1 2 2 2 0 Alpha/beta hydrolase family DUF1100 PF06500.9 001190904.1_29623001_3 - 0.13 10.9 0.0 0.17 10.5 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1100) DUF818 PF05677.10 001190904.1_29623001_3 - 0.13 11.0 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) IL6Ra-bind PF09240.8 001301846.1_08023001_3 - 1.9e-12 47.3 3.0 2.9e-12 46.7 3.0 1.3 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding fn3 PF00041.19 001301846.1_08023001_3 - 2.8e-06 27.4 0.8 1.8e-05 24.9 0.1 2.3 2 0 0 2 2 2 1 Fibronectin type III domain EpoR_lig-bind PF09067.8 001301846.1_08023001_3 - 3.9e-06 26.9 1.3 7.2e-06 26.0 1.3 1.3 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding IL4Ra_N PF09238.8 001301846.1_08023001_3 - 0.072 13.3 1.0 0.13 12.4 1.0 1.4 1 0 0 1 1 1 0 Interleukin-4 receptor alpha chain, N-terminal Ras PF00071.20 001194766.1_29623001_1 - 5.3e-59 198.3 0.5 6.9e-59 197.9 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001194766.1_29623001_1 - 5.9e-35 120.0 0.2 5.9e-35 120.0 0.2 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001194766.1_29623001_1 - 5.6e-17 61.6 0.7 8.5e-17 61.0 0.7 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001194766.1_29623001_1 - 1.6e-05 24.8 0.1 2.8e-05 24.1 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001194766.1_29623001_1 - 2.1e-05 24.0 1.4 4.5e-05 22.9 0.6 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 001194766.1_29623001_1 - 0.00012 21.4 0.3 0.0002 20.7 0.1 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF258 PF03193.14 001194766.1_29623001_1 - 0.0007 19.4 1.0 0.077 12.8 0.1 2.3 1 1 1 2 2 2 1 Protein of unknown function, DUF258 PduV-EutP PF10662.7 001194766.1_29623001_1 - 0.0038 16.8 0.2 0.042 13.5 0.2 2.3 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.16 001194766.1_29623001_1 - 0.022 14.1 0.2 0.071 12.5 0.2 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_16 PF13191.4 001194766.1_29623001_1 - 0.025 14.8 0.0 0.046 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 001194766.1_29623001_1 - 0.037 14.2 0.0 0.077 13.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.4 001194766.1_29623001_1 - 0.047 13.3 0.0 0.096 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain SRPRB PF09439.8 001194766.1_29623001_1 - 0.061 12.6 0.0 0.061 12.6 0.0 1.7 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_24 PF13479.4 001194766.1_29623001_1 - 0.072 12.7 0.4 0.14 11.7 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA PF00004.27 001194766.1_29623001_1 - 0.091 13.1 0.2 0.91 9.8 0.0 2.2 1 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.25 001194766.1_29623001_1 - 0.6 10.5 1.9 1.1 9.6 1.9 1.6 1 1 0 1 1 1 0 ABC transporter MHC_I PF00129.16 001318348.1_29623001_1 - 1.5e-95 317.7 0.5 2.2e-95 317.2 0.5 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001318348.1_29623001_1 - 8.2e-17 61.3 0.0 1.6e-16 60.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001318348.1_29623001_1 - 8.3e-15 54.3 9.9 1.5e-14 53.5 9.9 1.4 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 001318348.1_29623001_1 - 3e-06 27.6 0.6 0.019 15.4 0.0 2.8 1 1 1 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001318348.1_29623001_1 - 0.00017 21.5 0.1 0.00038 20.3 0.1 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001318348.1_29623001_1 - 0.0061 16.6 0.1 0.021 14.8 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain DUF4448 PF14610.4 001318348.1_29623001_1 - 0.049 13.3 0.0 0.08 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Arf PF00025.19 001194262.1_29622001_3 - 4.2e-52 176.0 0.0 5.6e-52 175.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001194262.1_29622001_3 - 7e-11 41.8 0.0 1e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.11 001194262.1_29622001_3 - 5.1e-09 36.3 0.0 7.9e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001194262.1_29622001_3 - 4.7e-07 29.4 0.0 6.3e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Ras family G-alpha PF00503.18 001194262.1_29622001_3 - 2.3e-06 26.9 0.0 0.00043 19.4 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 001194262.1_29622001_3 - 1.2e-05 24.7 0.0 1.6e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001194262.1_29622001_3 - 0.00017 21.5 0.0 0.00025 21.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.16 001194262.1_29622001_3 - 0.12 11.5 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase DLIC PF05783.9 001194262.1_29622001_3 - 0.21 10.2 0.1 0.31 9.7 0.1 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) SMAP PF15477.4 001193864.1_29624001_2 - 3.4e-11 43.8 1.5 3.4e-11 43.8 1.5 1.6 2 0 0 2 2 2 1 Small acidic protein family DUF3408 PF11888.6 001193864.1_29624001_2 - 0.077 13.0 2.3 0.16 12.0 2.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) BUD22 PF09073.8 001193864.1_29624001_2 - 0.37 9.9 16.6 0.48 9.6 16.6 1.1 1 0 0 1 1 1 0 BUD22 NOA36 PF06524.10 001193864.1_29624001_2 - 9.4 5.4 13.0 15 4.8 13.0 1.2 1 0 0 1 1 1 0 NOA36 protein Ras PF00071.20 001194908.1_29624001_2 - 2.4e-56 189.7 0.0 3.1e-56 189.3 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001194908.1_29624001_2 - 4.3e-29 101.1 0.0 7.3e-29 100.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001194908.1_29624001_2 - 2.6e-11 43.1 0.0 3.7e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001194908.1_29624001_2 - 4.5e-05 23.4 0.0 0.00015 21.7 0.0 1.9 1 1 1 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.14 001194908.1_29624001_2 - 0.00031 20.5 0.1 0.036 13.8 0.2 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 Gtr1_RagA PF04670.10 001194908.1_29624001_2 - 0.0045 16.2 0.0 0.0064 15.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001194908.1_29624001_2 - 0.14 11.6 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Abhydrolase_1 PF00561.18 001319344.1_29525001_2 - 1.8e-23 83.4 0.1 1e-17 64.5 0.1 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 001319344.1_29525001_2 - 4.7e-16 58.6 1.4 8.7e-15 54.5 1.4 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.5 001319344.1_29525001_2 - 1.8e-14 54.7 0.1 1.8e-14 54.7 0.1 2.4 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.14 001319344.1_29525001_2 - 0.0031 17.2 0.1 1.7 8.2 0.0 2.8 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase DUF2920 PF11144.6 001319344.1_29525001_2 - 0.0065 15.5 0.0 1.4 7.9 0.0 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF2920) FSH1 PF03959.11 001319344.1_29525001_2 - 0.036 13.6 0.0 0.061 12.8 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Peptidase_S9 PF00326.19 001319344.1_29525001_2 - 0.039 13.3 0.0 0.2 11.0 0.0 2.0 2 0 0 2 2 2 0 Prolyl oligopeptidase family Abhydrolase_4 PF08386.8 001319344.1_29525001_2 - 0.054 13.5 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 TAP-like protein Peptidase_S15 PF02129.16 001319344.1_29525001_2 - 0.056 12.9 0.0 3.2 7.1 0.0 2.2 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_8 PF06259.10 001319344.1_29525001_2 - 0.12 11.9 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase DLH PF01738.16 001319344.1_29525001_2 - 0.16 11.3 0.0 17 4.7 0.0 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family Serglycin PF04360.10 001319344.1_29525001_2 - 1.5 8.6 6.5 2.7 7.8 6.5 1.3 1 0 0 1 1 1 0 Serglycin V-set PF07686.15 001302787.1_08023001_3 - 0.041 13.9 0.3 0.069 13.2 0.3 1.3 1 0 0 1 1 1 0 Immunoglobulin V-set domain DEAD PF00270.27 001276454.2_39526001_3 - 3.9e-46 156.9 0.0 9.5e-46 155.6 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase GUCT PF08152.10 001276454.2_39526001_3 - 1.1e-30 105.7 0.0 3.4e-30 104.0 0.0 1.9 1 0 0 1 1 1 1 GUCT (NUC152) domain Helicase_C PF00271.29 001276454.2_39526001_3 - 2.2e-29 101.9 0.1 5.3e-28 97.5 0.0 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.13 001276454.2_39526001_3 - 4.5e-08 33.1 0.0 4.5e-08 33.1 0.0 2.5 1 1 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.4 001276454.2_39526001_3 - 0.0001 21.6 0.0 0.0001 21.6 0.0 2.8 2 1 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit AAA_30 PF13604.4 001276454.2_39526001_3 - 0.00061 19.4 0.0 0.0052 16.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain ERCC3_RAD25_C PF16203.3 001276454.2_39526001_3 - 0.014 14.5 0.0 0.014 14.5 0.0 1.8 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase WD40 PF00400.30 001301706.1_29625001_3 - 3.5e-32 109.8 32.4 5.1e-05 23.8 0.5 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat NLE PF08154.10 001301706.1_29625001_3 - 1.4e-16 60.6 0.1 3.2e-16 59.5 0.1 1.6 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.6 001301706.1_29625001_3 - 0.095 11.2 8.4 0.12 10.9 0.3 3.0 1 1 1 3 3 3 0 Nucleoporin Nup120/160 RNase_T PF00929.22 001193813.1_29623001_3 - 7.5e-33 114.3 0.0 9.4e-33 113.9 0.0 1.1 1 0 0 1 1 1 1 Exonuclease V-set PF07686.15 001302788.1_08023001_3 - 0.037 14.0 0.3 0.063 13.3 0.3 1.3 1 0 0 1 1 1 0 Immunoglobulin V-set domain DUF1143 PF06608.9 001194787.1_29622001_2 - 4e-95 315.6 7.5 5.1e-95 315.3 7.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1143) U1snRNP70_N PF12220.6 001194787.1_29622001_3 - 0.051 14.1 0.0 0.11 13.0 0.0 1.5 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal TB2_DP1_HVA22 PF03134.17 001194035.1_29623001_2 - 1.1e-26 92.4 2.7 1.6e-26 91.9 2.7 1.2 1 0 0 1 1 1 1 TB2/DP1, HVA22 family adh_short PF00106.23 001193746.2_29622001_1 - 8.5e-36 123.1 0.0 3.4e-27 95.1 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.4 001193746.2_29622001_1 - 9.2e-28 97.2 0.0 8.5e-20 71.2 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001193746.2_29622001_1 - 3.3e-08 33.5 0.1 5.6e-08 32.8 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.19 001193746.2_29622001_1 - 8.5e-05 22.0 0.0 0.00044 19.6 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 001193746.2_29622001_1 - 0.066 12.4 0.1 15 4.7 0.0 2.6 2 1 1 3 3 3 0 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.16 001193746.2_29622001_1 - 0.081 13.1 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain adh_short_C2 PF13561.4 001193693.1_29623001_1 - 1.6e-60 204.4 1.1 2.1e-60 204.1 1.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.23 001193693.1_29623001_1 - 2.9e-55 186.6 1.8 3.5e-55 186.4 1.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.8 001193693.1_29623001_1 - 6.7e-15 55.3 1.8 9.9e-15 54.8 1.8 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.4 001193693.1_29623001_1 - 8.5e-05 22.4 0.4 0.00011 22.0 0.4 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Glyco_transf_5 PF08323.9 001193693.1_29623001_1 - 0.039 13.5 0.1 0.085 12.4 0.1 1.5 1 0 0 1 1 1 0 Starch synthase catalytic domain Hist_deacetyl PF00850.17 001194196.1_29629001_2 - 8.8e-173 573.7 0.0 4.4e-87 292.3 0.0 2.2 2 0 0 2 2 2 2 Histone deacetylase domain zf-UBP PF02148.17 001194196.1_29629001_2 - 1.9e-17 63.2 13.5 5.3e-17 61.8 13.5 1.8 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein FYVE PF01363.19 001193870.1_29626001_2 - 1.7e-17 63.1 7.4 1.7e-17 63.1 7.4 2.8 3 1 0 3 3 3 1 FYVE zinc finger PH PF00169.27 001193870.1_29626001_2 - 8.9e-10 38.9 0.1 1.9e-09 37.9 0.1 1.6 1 0 0 1 1 1 1 PH domain FYVE_2 PF02318.14 001193870.1_29626001_2 - 0.0033 17.5 4.3 0.0084 16.2 4.3 1.6 1 0 0 1 1 1 1 FYVE-type zinc finger zf-C2H2 PF00096.24 001194253.1_29625001_1 - 1.8e-14 53.1 87.5 0.00013 22.1 5.8 10.3 10 0 0 10 10 10 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001194253.1_29625001_1 - 1.1e-13 50.5 80.7 0.00012 22.5 2.3 10.5 10 0 0 10 10 10 7 C2H2-type zinc finger zf-H2C2_2 PF13465.4 001194253.1_29625001_1 - 2.7e-12 46.4 61.5 4.8e-05 23.5 0.1 8.5 9 0 0 9 9 9 6 Zinc-finger double domain zf-C2H2_6 PF13912.4 001194253.1_29625001_1 - 0.0022 17.7 3.2 0.0022 17.7 3.2 5.9 6 1 0 6 6 6 2 C2H2-type zinc finger zf-Dof PF02701.13 001194253.1_29625001_1 - 0.0056 16.7 8.7 0.45 10.6 0.4 3.2 3 0 0 3 3 3 2 Dof domain, zinc finger Actin_micro PF17003.3 001194253.1_29625001_1 - 0.015 14.4 0.1 0.015 14.4 0.1 4.2 3 1 0 3 3 3 0 Putative actin-like family SLIDE PF09111.8 001194253.1_29625001_1 - 0.018 14.9 0.0 0.11 12.4 0.0 2.0 2 0 0 2 2 2 0 SLIDE zf-met PF12874.5 001194253.1_29625001_1 - 0.04 14.2 45.9 0.093 13.0 0.2 6.9 7 0 0 7 7 7 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.4 001194253.1_29625001_1 - 0.071 12.9 0.4 0.071 12.9 0.4 3.8 4 0 0 4 4 4 0 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.6 001194253.1_29625001_1 - 0.16 12.2 44.9 0.044 14.0 1.4 6.8 7 0 0 7 7 7 0 Zinc-finger double-stranded RNA-binding ASF1_hist_chap PF04729.11 001194486.1_29626001_2 - 5.5e-71 237.4 0.1 7.6e-71 236.9 0.1 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone zf-C2H2 PF00096.24 001190952.1_29622001_1 - 0.00067 19.9 13.1 0.32 11.4 0.2 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_aberr PF17017.3 001190952.1_29622001_1 - 0.0019 18.2 1.8 0.25 11.3 0.2 2.2 1 1 0 2 2 2 2 Aberrant zinc-finger zf-C2H2_4 PF13894.4 001190952.1_29622001_1 - 0.0093 16.6 15.5 0.3 11.9 0.4 3.9 4 0 0 4 4 4 3 C2H2-type zinc finger V-set PF07686.15 001302789.1_08023001_3 - 0.034 14.2 0.3 0.06 13.4 0.3 1.4 1 0 0 1 1 1 0 Immunoglobulin V-set domain Linker_histone PF00538.17 001193819.1_29622001_1 - 3.1e-23 81.8 0.6 3.1e-23 81.8 0.6 2.3 2 0 0 2 2 2 1 linker histone H1 and H5 family fn3 PF00041.19 001317360.1_39525001_3 - 1.2e-17 63.9 2.2 4.5e-15 55.6 0.6 3.1 3 0 0 3 3 3 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 001317360.1_39525001_3 - 1.3e-05 25.5 0.5 8.7e-05 22.9 0.4 2.4 2 1 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 001317360.1_39525001_3 - 0.029 14.6 0.0 0.12 12.6 0.0 2.1 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III fn3_2 PF16893.3 001317360.1_39525001_3 - 0.036 14.1 0.0 0.088 12.8 0.0 1.6 1 0 0 1 1 1 0 Fibronectin type III domain DUF4201 PF13870.4 001319380.1_29523001_3 - 0.016 14.7 4.7 0.016 14.7 4.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) XhlA PF10779.7 001319380.1_29523001_3 - 0.033 14.2 4.1 0.11 12.6 4.1 2.0 1 0 0 1 1 1 0 Haemolysin XhlA NPV_P10 PF05531.10 001319380.1_29523001_3 - 0.39 11.1 4.8 6.9 7.1 0.1 2.8 1 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein TSC22 PF01166.16 001319380.1_29523001_3 - 0.41 10.9 3.2 0.48 10.6 0.3 2.6 3 0 0 3 3 3 0 TSC-22/dip/bun family ODC_AZ PF02100.15 001301337.1_08024001_2 - 1.9e-19 69.6 0.0 3.8e-19 68.7 0.0 1.4 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme V-set PF07686.15 001302790.1_08022001_1 - 0.031 14.3 0.3 0.053 13.6 0.3 1.4 1 0 0 1 1 1 0 Immunoglobulin V-set domain Keratin_matx PF04579.10 001308573.1_39521001_1 - 2.1e-48 162.5 29.5 2.3e-48 162.3 29.5 1.0 1 0 0 1 1 1 1 Keratin, high-sulphur matrix protein PAP2_C PF14360.4 001193740.1_29625001_1 - 6e-26 90.6 13.2 6e-26 90.6 13.2 2.3 2 0 0 2 2 2 1 PAP2 superfamily C-terminal PAP2 PF01569.19 001193740.1_29625001_1 - 2.5e-07 30.4 7.1 6.8e-07 29.0 7.1 1.9 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.4 001193740.1_29625001_1 - 0.076 12.6 11.2 0.041 13.4 7.0 2.3 2 0 0 2 2 2 0 PAP2 superfamily Tim17 PF02466.17 001190973.1_29623001_1 - 7.9e-18 64.6 6.5 7.9e-18 64.6 6.5 1.6 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family Orn_Arg_deC_N PF02784.14 001266222.3_29624001_1 - 4.7e-73 245.5 0.0 5.9e-73 245.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001266222.3_29624001_1 - 5.8e-21 74.5 0.0 1e-20 73.8 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.22 001266222.3_29624001_1 - 4.7e-06 26.1 0.0 9.2e-06 25.1 0.0 1.4 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel zf-C3HC4_4 PF15227.4 001318172.1_29622001_1 - 1.2e-14 54.1 1.4 1.2e-14 54.1 1.4 3.4 4 0 0 4 4 3 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 001318172.1_29622001_1 - 1.1e-10 41.1 1.0 1.1e-10 41.1 1.0 2.7 3 1 0 3 3 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 001318172.1_29622001_1 - 8.7e-10 38.2 1.4 8.7e-10 38.2 1.4 2.9 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001318172.1_29622001_1 - 1.4e-09 37.6 1.1 1.4e-09 37.6 1.1 3.4 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001318172.1_29622001_1 - 1.6e-09 37.7 2.2 1.6e-09 37.7 2.2 4.1 5 0 0 5 5 5 1 B-box zinc finger zf-RING_2 PF13639.4 001318172.1_29622001_1 - 4.1e-06 26.8 1.9 4.1e-06 26.8 1.9 3.5 2 1 1 3 3 2 1 Ring finger domain zf-C3HC4_3 PF13920.4 001318172.1_29622001_1 - 4.5e-06 26.3 1.0 4.5e-06 26.3 1.0 3.8 3 1 1 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001318172.1_29622001_1 - 0.00046 20.0 0.9 0.00046 20.0 0.9 3.9 3 1 0 3 3 2 1 zinc-RING finger domain zf-RING_10 PF16685.3 001318172.1_29622001_1 - 0.0069 16.4 0.2 0.0069 16.4 0.2 3.2 2 1 1 3 3 3 1 zinc RING finger of MSL2 zf-H2C2_2 PF13465.4 001318172.1_29622001_1 - 0.011 16.1 2.5 0.023 15.0 0.4 2.4 2 0 0 2 2 2 0 Zinc-finger double domain Prok-RING_4 PF14447.4 001318172.1_29622001_1 - 0.017 14.8 2.2 0.017 14.8 2.2 3.7 4 0 0 4 4 4 0 Prokaryotic RING finger family 4 zf-RING_6 PF14835.4 001318172.1_29622001_1 - 0.027 14.2 0.6 0.027 14.2 0.6 2.1 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-RING_11 PF17123.3 001318172.1_29622001_1 - 0.77 9.4 7.7 0.65 9.6 4.8 2.3 2 0 0 2 2 2 0 RING-like zinc finger zf-Di19 PF05605.10 001318172.1_29622001_1 - 2.8 8.2 15.4 0.58 10.3 2.6 3.4 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding RRM_1 PF00076.20 001190901.1_29623001_1 - 1.8e-10 40.4 0.0 4.2e-10 39.2 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 001190901.1_29623001_1 - 0.035 13.6 0.0 0.11 12.0 0.0 1.8 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TLV_coat PF00429.17 001308377.1_32325001_3 - 8.3e-91 305.2 0.0 1.1e-90 304.8 0.0 1.2 1 0 0 1 1 1 1 ENV polyprotein (coat polyprotein) PsbL PF02419.15 001308377.1_32325001_3 - 1.2 9.0 5.7 2.6 8.0 5.7 1.6 1 0 0 1 1 1 0 PsbL protein Orn_Arg_deC_N PF02784.14 001291507.1_39528001_1 - 2.3e-63 213.8 0.1 2.9e-63 213.4 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001291507.1_39528001_1 - 1e-23 83.4 0.0 1.7e-23 82.7 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain RhoGEF PF00621.18 001204918.1_29626001_1 - 1.4e-29 103.5 0.0 2.1e-29 102.9 0.0 1.2 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 001204918.1_29626001_1 - 0.00065 20.1 0.0 0.0011 19.3 0.0 1.4 1 0 0 1 1 1 1 PH domain Orn_Arg_deC_N PF02784.14 001291457.1_08029001_1 - 4.9e-64 216.0 0.2 6.2e-64 215.7 0.2 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001291457.1_08029001_1 - 1.8e-24 85.8 0.0 3e-24 85.1 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Fibin PF15819.3 001193892.2_29623001_3 - 7.3e-105 348.6 1.5 9.1e-105 348.3 1.5 1.1 1 0 0 1 1 1 1 Fin bud initiation factor homologue SRRM_C PF15230.4 001110199.2_26228001_2 - 6e-24 84.2 21.5 6e-24 84.2 21.5 8.9 4 3 3 7 7 7 1 Serine/arginine repetitive matrix protein C-terminus cwf21 PF08312.10 001110199.2_26228001_2 - 6.8e-15 54.8 7.3 6.8e-15 54.8 7.3 1.7 2 0 0 2 2 2 1 cwf21 domain GCR PF02155.13 001305031.1_22425001_1 - 1.3e-178 593.6 9.1 1.7e-178 593.2 9.1 1.1 1 0 0 1 1 1 1 Glucocorticoid receptor Hormone_recep PF00104.28 001305031.1_22425001_1 - 7.2e-31 107.3 7.3 2.5e-30 105.5 5.6 2.0 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001305031.1_22425001_1 - 2.9e-28 98.0 13.0 5.5e-28 97.1 13.0 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Peptidase_C1 PF00112.21 001314352.1_09023001_3 - 2.4e-69 233.7 0.1 3.2e-69 233.2 0.1 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 001314352.1_09023001_3 - 9e-09 35.5 0.5 1.5e-08 34.8 0.5 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 001314352.1_09023001_3 - 0.00051 18.8 0.7 0.01 14.5 0.0 2.2 2 0 0 2 2 2 2 Peptidase C1-like family Cyt-b5 PF00173.26 001193767.1_29625001_3 - 1.7e-24 85.6 0.0 3.6e-24 84.6 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FAD_binding_6 PF00970.22 001193767.1_29625001_3 - 6.3e-20 71.2 0.0 1.9e-19 69.7 0.0 1.9 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.19 001193767.1_29625001_3 - 9.4e-17 61.5 0.0 3.1e-16 59.8 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain CS PF04969.14 001193767.1_29625001_3 - 3.2e-11 43.9 1.5 7.9e-11 42.7 1.5 1.7 1 0 0 1 1 1 1 CS domain NAD_binding_6 PF08030.10 001193767.1_29625001_3 - 0.00066 19.7 0.1 0.0091 16.0 0.0 2.2 1 1 0 2 2 2 1 Ferric reductase NAD binding domain MHC_II_alpha PF00993.18 001314188.1_09022001_1 - 1.6e-36 123.7 0.2 2.2e-36 123.3 0.2 1.2 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001314188.1_09022001_1 - 3.8e-27 93.3 0.1 1.1e-26 91.9 0.1 1.8 1 0 0 1 1 1 1 C1-set C-terminal domain C1-set PF07654.13 001314188.1_09022001_1 - 2.3e-22 79.1 0.0 3.4e-22 78.6 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001314188.1_09022001_1 - 4.8e-05 23.8 0.0 8.1e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Marek_A PF02124.13 001314188.1_09022001_1 - 0.022 14.5 0.0 0.035 13.8 0.0 1.3 1 0 0 1 1 1 0 Marek's disease glycoprotein A DUF4201 PF13870.4 001319381.1_29525001_2 - 2.7e-51 173.6 23.0 2.7e-51 173.6 23.0 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4201) CCDC92 PF14916.4 001319381.1_29525001_2 - 2.4 7.9 12.1 0.6 9.8 3.9 3.3 2 0 0 2 2 2 0 Coiled-coil domain of unknown function zf-H2C2_2 PF13465.4 001194124.1_29629001_1 - 5.1e-42 140.4 44.0 1.3e-09 38.0 0.4 7.6 7 0 0 7 7 6 6 Zinc-finger double domain SCAN PF02023.15 001194124.1_29629001_1 - 3.2e-40 135.7 1.7 5.7e-40 134.9 1.7 1.4 1 0 0 1 1 1 1 SCAN domain zf-C2H2 PF00096.24 001194124.1_29629001_1 - 5.2e-34 114.7 49.3 8.6e-07 29.0 0.4 7.7 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001194124.1_29629001_1 - 3.4e-11 42.8 44.5 0.02 15.5 0.4 7.8 7 0 0 7 7 6 6 C2H2-type zinc finger KRAB PF01352.25 001194124.1_29629001_1 - 2.2e-08 33.5 0.0 3.9e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 001194124.1_29629001_1 - 3.2e-08 33.2 39.7 0.17 11.7 1.9 6.9 7 0 0 7 7 6 6 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001194124.1_29629001_1 - 1.3e-06 28.3 24.9 0.01 15.8 1.4 4.8 3 1 2 5 5 5 4 Zinc ribbon domain zf-C2H2_11 PF16622.3 001194124.1_29629001_1 - 1.2e-05 24.8 29.6 0.00057 19.5 4.4 6.4 6 0 0 6 6 6 3 zinc-finger C2H2-type C1_4 PF07975.10 001194124.1_29629001_1 - 0.2 11.8 20.4 0.76 10.0 1.6 4.9 1 1 3 5 5 5 0 TFIIH C1-like domain XPA_N PF01286.16 001194124.1_29629001_1 - 0.95 9.4 37.2 5.7 6.9 0.3 7.0 7 0 0 7 7 6 0 XPA protein N-terminal zinc_ribbon_15 PF17032.3 001194124.1_29629001_1 - 1.4 9.5 20.5 4.1 8.1 1.4 4.2 1 1 3 4 4 4 0 zinc-ribbon family DUF3268 PF11672.6 001194124.1_29629001_1 - 1.7 8.8 11.5 5 7.4 0.2 3.3 3 0 0 3 3 3 0 zinc-finger-containing domain C1q PF00386.19 001308565.1_39525001_3 - 1.1e-39 135.4 1.6 1.5e-39 135.0 1.6 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.16 001308565.1_39525001_3 - 3e-09 36.4 31.6 1.6e-07 30.9 31.6 2.3 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) 7tm_1 PF00001.19 001309044.1_22423001_1 - 3.8e-33 114.8 18.3 5.4e-33 114.2 18.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2678 PF10856.6 001309044.1_22423001_1 - 6.8 6.5 9.2 1.2 9.0 4.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2678) SRAP PF02586.12 001194040.1_29624001_1 - 4.7e-65 219.1 0.0 8.9e-65 218.2 0.0 1.5 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) DUF4939 PF16297.3 001302558.1_08029001_1 - 3.7e-15 55.7 0.0 6.5e-15 54.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Retrotrans_gag PF03732.15 001302558.1_08029001_1 - 4.9e-15 55.5 1.9 1.8e-14 53.6 0.0 2.3 2 0 0 2 2 2 1 Retrotransposon gag protein Rootletin PF15035.4 001302558.1_08029001_1 - 0.00029 20.8 0.1 0.00056 19.9 0.1 1.4 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion KASH_CCD PF14662.4 001302558.1_08029001_1 - 0.002 17.9 4.6 0.0034 17.1 4.6 1.3 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH zf-CCHC_5 PF14787.4 001302558.1_08029001_1 - 0.0027 17.3 0.2 0.0064 16.1 0.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger Spc29 PF17082.3 001302558.1_08029001_1 - 0.0075 16.0 0.5 0.012 15.3 0.5 1.2 1 0 0 1 1 1 1 Spindle Pole Component 29 CCDC106 PF15794.3 001302558.1_08029001_1 - 0.26 10.8 4.2 0.81 9.2 2.3 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 SlyX PF04102.10 001302558.1_08029001_1 - 0.34 11.4 2.4 0.82 10.2 2.4 1.7 1 0 0 1 1 1 0 SlyX bZIP_1 PF00170.19 001302558.1_08029001_1 - 0.36 10.8 4.8 1.1 9.3 4.8 1.8 1 0 0 1 1 1 0 bZIP transcription factor CENP-H PF05837.10 001302558.1_08029001_1 - 0.39 11.0 4.7 0.84 9.9 4.7 1.5 1 0 0 1 1 1 0 Centromere protein H (CENP-H) ZapB PF06005.10 001302558.1_08029001_1 - 0.62 10.4 9.7 1.4 9.3 9.7 1.5 1 0 0 1 1 1 0 Cell division protein ZapB DUF972 PF06156.11 001302558.1_08029001_1 - 0.73 10.4 3.9 1.9 9.0 3.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF972) DivIC PF04977.13 001302558.1_08029001_1 - 3.6 7.3 7.1 8.6 6.1 7.1 1.6 1 0 0 1 1 1 0 Septum formation initiator GIT_CC PF16559.3 001302558.1_08029001_1 - 4.4 7.3 7.8 16 5.5 7.8 2.0 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor CAP_N PF01213.17 001302558.1_08029001_1 - 7.1 5.9 9.4 13 5.0 9.4 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal SHE3 PF17078.3 001302558.1_08029001_1 - 8 6.0 10.2 2.1 7.8 7.1 1.5 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 Asp_protease_2 PF13650.4 001302558.1_08029001_3 - 0.00078 20.0 0.0 0.0012 19.3 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001302558.1_08029001_3 - 0.016 15.1 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001302558.1_08029001_3 - 0.052 14.0 0.0 0.085 13.3 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Acyltransferase PF01553.19 001194646.1_29625001_2 - 4.4e-33 113.6 0.0 6.3e-33 113.1 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase FGF PF00167.16 001194006.2_29626001_1 - 2e-39 134.4 0.1 2.9e-39 133.9 0.1 1.2 1 0 0 1 1 1 1 Fibroblast growth factor DUF1968 PF09291.8 001315811.1_49822001_1 - 5.5e-28 96.7 1.1 1.1e-27 95.8 1.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1968) V-set PF07686.15 001315811.1_49822001_1 - 1.5e-13 50.7 0.5 4.6e-13 49.1 0.1 1.9 2 1 1 3 3 3 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001315811.1_49822001_1 - 1e-05 25.9 0.6 4e-05 24.0 0.1 2.1 2 1 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 001315811.1_49822001_1 - 1.5e-05 24.8 0.0 3.5e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 001315811.1_49822001_1 - 0.00097 19.3 0.3 0.0045 17.2 0.2 2.2 2 1 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001315811.1_49822001_1 - 0.006 16.6 0.1 0.016 15.2 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain PTPLA PF04387.12 001194139.2_29625001_3 - 6.9e-34 116.8 13.5 1e-33 116.3 13.5 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA 7tm_1 PF00001.19 001302782.1_29624001_2 - 7.9e-45 153.0 26.9 1.1e-44 152.6 26.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001302782.1_29624001_2 - 7.1e-13 48.8 23.6 1.1e-12 48.2 23.6 1.1 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001302782.1_29624001_2 - 1.9e-10 40.4 28.3 2.8e-10 39.9 28.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx ATG27 PF09451.8 001302782.1_29624001_2 - 0.89 9.2 2.9 1.8 8.2 2.9 1.4 1 0 0 1 1 1 0 Autophagy-related protein 27 Orn_Arg_deC_N PF02784.14 001293699.1_08024001_1 - 3.6e-70 236.1 0.0 4.6e-70 235.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001293699.1_08024001_1 - 5.1e-21 74.7 0.0 8.7e-21 74.0 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.22 001293699.1_08024001_1 - 0.00032 20.1 0.0 0.00066 19.0 0.0 1.4 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel HECT PF00632.23 001319872.1_08029001_1 - 2.2e-99 332.7 0.3 3e-99 332.2 0.3 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.24 001319872.1_08029001_1 - 3.4e-39 132.3 23.8 2.2e-12 46.5 3.4 4.8 4 0 0 4 4 4 4 WW domain zf-H2C2_2 PF13465.4 001314273.1_09025001_1 - 5.8e-36 121.2 52.7 1.2e-07 31.7 1.4 9.7 10 0 0 10 10 10 7 Zinc-finger double domain zf-C2H2_4 PF13894.4 001314273.1_09025001_1 - 3.5e-28 95.7 59.9 0.00016 22.1 1.8 9.6 9 0 0 9 9 9 9 C2H2-type zinc finger zf-C2H2 PF00096.24 001314273.1_09025001_1 - 3.6e-27 93.1 61.1 0.00025 21.2 2.6 9.4 9 0 0 9 9 9 8 Zinc finger, C2H2 type BTB PF00651.29 001314273.1_09025001_1 - 3.6e-26 91.4 2.9 6.9e-26 90.5 2.9 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_jaz PF12171.6 001314273.1_09025001_1 - 4.6e-15 55.3 39.3 0.00018 21.6 0.4 9.7 10 0 0 10 10 10 5 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001314273.1_09025001_1 - 1.5e-13 50.2 51.4 5.5e-06 26.1 1.2 9.4 9 0 0 9 9 9 4 C2H2-type zinc finger zf-met PF12874.5 001314273.1_09025001_1 - 4.5e-13 49.0 53.0 5.2e-05 23.3 1.1 9.6 9 0 0 9 9 9 5 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.5 001314273.1_09025001_1 - 0.0027 17.9 44.3 0.35 11.1 0.4 8.3 1 1 8 9 9 9 3 C2H2 type zinc-finger (2 copies) Endonuclease_7 PF02945.13 001314273.1_09025001_1 - 0.02 14.7 1.3 0.02 14.7 1.3 4.1 2 2 2 4 4 4 0 Recombination endonuclease VII DZR PF12773.5 001314273.1_09025001_1 - 0.021 14.7 30.1 1.5e+02 2.4 1.6 5.3 2 1 0 2 2 1 0 Double zinc ribbon zinc_ribbon_15 PF17032.3 001314273.1_09025001_1 - 0.051 14.2 26.7 1 10.0 1.9 5.2 1 1 4 5 5 5 0 zinc-ribbon family DUF3268 PF11672.6 001314273.1_09025001_1 - 1.6 9.0 21.3 6.6 7.0 0.2 4.8 4 1 1 5 5 5 0 zinc-finger-containing domain zf-C2H2_11 PF16622.3 001314273.1_09025001_1 - 4 7.2 51.6 0.03 14.0 1.4 8.4 9 0 0 9 9 9 0 zinc-finger C2H2-type TMEM107 PF14995.4 001194554.1_29622001_3 - 1.7e-45 154.3 6.9 2.5e-45 153.8 6.9 1.2 1 0 0 1 1 1 1 Transmembrane protein MSA-2c PF12238.6 001301313.1_29621001_1 - 0.27 11.1 2.0 0.32 10.9 2.0 1.1 1 0 0 1 1 1 0 Merozoite surface antigen 2c Metallothio PF00131.18 001301313.1_29621001_3 - 6.2e-19 67.7 64.8 9e-19 67.2 64.8 1.2 1 0 0 1 1 1 1 Metallothionein Methyltransf_16 PF10294.7 001194202.1_29623001_1 - 1.6e-15 57.1 0.5 1.2e-13 51.0 0.5 2.1 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.4 001194202.1_29623001_1 - 0.014 16.0 0.1 0.041 14.5 0.1 1.8 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.12 001194202.1_29623001_1 - 0.027 13.9 0.1 0.072 12.5 0.1 1.6 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_11 PF08241.10 001194202.1_29623001_1 - 0.082 13.4 0.0 0.19 12.2 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.11 001194202.1_29623001_1 - 0.19 11.0 0.1 0.32 10.2 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Complex1_LYR PF05347.13 001194866.2_29622001_2 - 0.029 14.3 0.1 0.057 13.4 0.1 1.5 1 0 0 1 1 1 0 Complex 1 protein (LYR family) FAM219A PF15260.4 001193839.1_29628001_2 - 2e-52 176.7 3.0 3.4e-52 175.9 3.0 1.4 1 0 0 1 1 1 1 Protein family FAM219A UCH PF00443.27 001329902.1_45729001_3 - 1.5e-48 165.5 0.3 4.2e-48 164.0 0.3 1.8 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 001329902.1_45729001_3 - 9.5e-22 77.8 0.0 1.4e-20 74.0 0.0 2.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase EcoEI_R_C PF08463.8 001329902.1_45729001_3 - 0.0017 18.4 3.8 0.03 14.3 1.2 3.1 3 0 0 3 3 3 1 EcoEI R protein C-terminal DUF2407 PF10302.7 001329902.1_45729001_3 - 0.0031 17.9 0.1 0.018 15.5 0.1 2.3 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain Utp13 PF08625.9 001329902.1_45729001_3 - 0.052 13.3 4.3 2 8.1 0.4 3.2 3 0 0 3 3 3 0 Utp13 specific WD40 associated domain zf-H2C2_2 PF13465.4 001329902.1_45729001_3 - 1.6 9.2 6.3 6.2 7.3 1.5 3.2 2 0 0 2 2 2 0 Zinc-finger double domain SWIM PF04434.15 001252000.1_39725001_3 - 9.7e-08 31.4 3.9 9.7e-08 31.4 3.9 2.0 2 0 0 2 2 2 1 SWIM zinc finger Defensin_propep PF00879.16 001033905.2_39721001_1 - 1.5e-26 92.3 0.6 1.9e-26 92.0 0.6 1.1 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001033905.2_39721001_1 - 0.00016 22.0 8.4 0.0002 21.7 8.4 1.2 1 0 0 1 1 1 1 Mammalian defensin Tubulin PF00091.23 001163055.2_39523001_2 - 2.2e-67 227.0 0.0 2.9e-67 226.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 001163055.2_39523001_2 - 2.4e-51 173.1 0.0 3.7e-51 172.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 001163055.2_39523001_2 - 0.0086 15.6 0.0 0.016 14.7 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain MHC_II_beta PF00969.17 001267752.2_08023001_2 - 2.1e-39 133.4 1.0 3.9e-39 132.5 1.0 1.4 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001267752.2_08023001_2 - 5.9e-25 87.4 0.6 9.8e-25 86.7 0.2 1.6 2 0 0 2 2 2 1 Immunoglobulin C1-set domain ig PF00047.23 001267752.2_08023001_2 - 3.2e-05 23.9 0.2 5.2e-05 23.2 0.2 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 001267752.2_08023001_2 - 9.7e-05 22.8 0.2 0.0004 20.8 0.0 1.9 1 1 1 2 2 2 1 Immunoglobulin domain I-set PF07679.14 001267752.2_08023001_2 - 0.15 12.0 0.1 0.34 10.9 0.1 1.6 1 1 0 1 1 1 0 Immunoglobulin I-set domain V-set PF07686.15 001329065.1_37922001_1 - 1e-09 38.4 0.0 1.7e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain C2-set_2 PF08205.10 001329065.1_37922001_1 - 0.0029 17.5 3.0 0.0071 16.3 3.0 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Glycophorin_A PF01102.16 001329065.1_37922001_1 - 0.0041 17.2 0.0 0.013 15.6 0.0 1.8 2 0 0 2 2 2 1 Glycophorin A DUF3671 PF12420.6 001329065.1_37922001_1 - 0.03 14.3 0.2 0.062 13.3 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function I-set PF07679.14 001329065.1_37922001_1 - 0.054 13.4 0.1 6.5 6.8 0.0 2.5 2 0 0 2 2 2 0 Immunoglobulin I-set domain TMEM154 PF15102.4 001329065.1_37922001_1 - 0.064 13.0 0.0 0.14 11.9 0.0 1.6 2 0 0 2 2 2 0 TMEM154 protein family Ig_3 PF13927.4 001329065.1_37922001_1 - 0.58 10.7 5.4 2.5 8.6 0.2 2.7 2 1 0 2 2 2 0 Immunoglobulin domain ig PF00047.23 001329065.1_37922001_1 - 3.4 7.8 7.2 11 6.1 0.2 3.2 2 2 0 2 2 2 0 Immunoglobulin domain SH2 PF00017.22 001242373.2_39725001_1 - 7e-15 54.7 0.0 1.3e-14 53.9 0.0 1.5 1 0 0 1 1 1 1 SH2 domain Pkinase_Tyr PF07714.15 001278565.1_39529001_1 - 4.6e-101 337.3 0.0 6.4e-101 336.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.4 001278565.1_39529001_1 - 6.4e-58 193.2 13.4 1.1e-15 57.9 0.2 6.8 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.14 001278565.1_39529001_1 - 5.7e-50 167.2 7.2 8.5e-17 60.9 0.0 6.9 6 1 0 6 6 6 6 Immunoglobulin I-set domain Pkinase PF00069.23 001278565.1_39529001_1 - 1.3e-41 142.6 0.0 5.7e-30 104.4 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Ig_2 PF13895.4 001278565.1_39529001_1 - 1.7e-30 105.0 22.2 1.1e-10 41.6 0.1 8.5 7 2 0 7 7 7 4 Immunoglobulin domain ig PF00047.23 001278565.1_39529001_1 - 2.7e-29 101.0 13.2 1.3e-10 41.2 0.3 7.2 7 1 0 7 7 7 5 Immunoglobulin domain V-set PF07686.15 001278565.1_39529001_1 - 3.2e-17 62.5 15.8 0.0022 18.0 0.0 8.8 6 2 2 8 8 8 4 Immunoglobulin V-set domain C2-set_2 PF08205.10 001278565.1_39529001_1 - 7.8e-11 41.8 5.8 0.0012 18.7 0.1 4.7 4 0 0 4 4 4 3 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 001278565.1_39529001_1 - 2.4e-08 33.7 3.9 2.8 7.9 0.0 6.5 6 0 0 6 6 6 2 Izumo-like Immunoglobulin domain Ig_5 PF16681.3 001278565.1_39529001_1 - 8.6e-08 32.4 4.7 0.9 9.9 0.0 6.0 6 1 0 6 6 6 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 001278565.1_39529001_1 - 0.00014 22.0 8.6 1.3 9.3 0.0 6.1 6 0 0 6 6 6 2 T-cell surface glycoprotein CD3 delta chain Adeno_E3_CR1 PF02440.13 001278565.1_39529001_1 - 0.12 12.0 10.6 3.8 7.2 0.1 5.5 5 0 0 5 5 5 0 Adenovirus E3 region protein CR1 APOBEC_N PF08210.9 001346002.1_29624001_1 - 7.4e-110 364.6 11.9 3.7e-57 193.0 2.9 2.1 2 0 0 2 2 2 2 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001346002.1_29624001_1 - 1.1e-64 214.1 2.4 5.2e-33 112.7 0.1 2.5 2 0 0 2 2 2 2 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 001346002.1_29624001_1 - 1.1e-07 31.5 0.1 0.0029 17.3 0.1 2.2 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region Toxin-deaminase PF14424.4 001346002.1_29624001_1 - 0.00013 21.9 0.1 0.34 10.9 0.0 2.2 2 0 0 2 2 2 2 The BURPS668_1122 family of deaminases Hairy_orange PF07527.11 001346002.1_29624001_1 - 0.0031 17.5 0.1 0.9 9.7 0.0 2.4 2 0 0 2 2 2 2 Hairy Orange MafB19-deam PF14437.4 001346002.1_29624001_1 - 0.039 13.6 0.3 0.21 11.2 0.0 2.0 2 0 0 2 2 2 0 MafB19-like deaminase Synaphin PF05835.10 001285147.2_29522001_3 - 7.8e-42 142.8 17.7 9.4e-42 142.5 17.7 1.1 1 0 0 1 1 1 1 Synaphin protein DUF2570 PF10828.6 001285147.2_29522001_3 - 0.73 9.6 7.8 1.1 9.1 7.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) Spt5_N PF11942.6 001285147.2_29522001_3 - 1.4 9.9 18.8 0.22 12.4 11.6 2.1 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal RR_TM4-6 PF06459.10 001285147.2_29522001_3 - 1.4 8.5 10.6 2 8.1 10.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Arf PF00025.19 001126367.2_39526001_1 - 7.7e-76 253.3 0.0 1e-75 252.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 001126367.2_39526001_1 - 3.9e-13 49.5 0.0 5.7e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001126367.2_39526001_1 - 3.5e-12 46.1 0.0 4.6e-12 45.7 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.8 001126367.2_39526001_1 - 4.3e-09 35.9 0.0 6e-09 35.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 001126367.2_39526001_1 - 9.2e-09 34.8 0.4 1.5e-05 24.2 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 001126367.2_39526001_1 - 2.7e-08 33.3 0.0 3.7e-08 32.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001126367.2_39526001_1 - 0.00091 19.2 0.0 0.0014 18.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001126367.2_39526001_1 - 0.062 12.7 0.1 0.16 11.3 0.0 1.6 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain ArgK PF03308.14 001126367.2_39526001_1 - 0.23 10.3 0.2 1.2 7.9 0.0 1.9 2 0 0 2 2 2 0 ArgK protein SAC3 PF12209.6 001126367.2_39526001_2 - 0.036 14.1 0.0 0.66 10.1 0.0 2.2 2 0 0 2 2 2 0 Leucine permease transcriptional regulator helical domain ABC2_membrane PF01061.22 001329072.1_37925001_1 - 1.6e-39 135.3 25.5 2.9e-39 134.5 25.5 1.4 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.25 001329072.1_37925001_1 - 2.8e-21 76.4 0.0 4.8e-21 75.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.4 001329072.1_37925001_1 - 1.8e-05 24.6 3.4 0.087 12.5 0.1 2.8 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.17 001329072.1_37925001_1 - 5.5e-05 22.6 0.2 0.2 10.9 0.1 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.4 001329072.1_37925001_1 - 0.0015 18.9 0.8 0.0026 18.2 0.1 1.7 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.14 001329072.1_37925001_1 - 0.01 15.6 0.0 0.027 14.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ABC2_membrane_3 PF12698.5 001329072.1_37925001_1 - 0.041 12.9 29.6 0.17 10.8 29.6 2.0 1 1 0 1 1 1 0 ABC-2 family transporter protein AAA_29 PF13555.4 001329072.1_37925001_1 - 0.071 12.7 0.1 0.17 11.5 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Adeno_IVa2 PF02456.13 001329072.1_37925001_1 - 0.12 11.1 0.0 0.18 10.4 0.0 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein DUF1774 PF08611.8 001329072.1_37925001_1 - 4.7 7.5 10.0 11 6.2 10.0 1.6 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF1774) Sep15_SelM PF08806.9 001159399.3_29622001_1 - 2.6e-21 75.5 0.0 3.7e-21 75.0 0.0 1.2 1 0 0 1 1 1 1 Sep15/SelM redox domain DUF4148 PF13663.4 001159399.3_29622001_1 - 0.11 12.5 0.5 0.25 11.4 0.5 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) GSHPx PF00255.17 001115137.2_29623001_1 - 5.1e-40 135.3 0.1 6.9e-40 134.8 0.1 1.2 1 0 0 1 1 1 1 Glutathione peroxidase LysM PF01476.18 001115137.2_29623001_1 - 0.16 11.9 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 LysM domain CENP-S PF15630.4 001204892.1_39723001_3 - 2.2e-32 111.1 0.7 3.5e-32 110.5 0.7 1.3 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.4 001204892.1_39723001_3 - 4.1e-09 36.4 0.5 6.5e-09 35.7 0.5 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.22 001204892.1_39723001_3 - 0.01 16.1 1.2 0.01 16.1 1.2 1.8 1 1 1 2 2 2 0 Core histone H2A/H2B/H3/H4 COMMD1_N PF17221.1 001204892.1_39723001_3 - 0.016 15.3 0.6 0.027 14.6 0.6 1.3 1 0 0 1 1 1 0 COMMD1 N-terminal domain zf-H2C2_2 PF13465.4 001346672.1_32926001_2 - 3.8e-78 254.5 106.1 4.6e-10 39.4 0.3 13.5 14 0 0 14 14 14 12 Zinc-finger double domain zf-C2H2 PF00096.24 001346672.1_32926001_2 - 1.1e-31 107.4 120.8 4.4e-05 23.6 3.5 12.3 12 0 0 12 12 12 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001346672.1_32926001_2 - 2.8e-28 96.0 113.1 0.00054 20.4 3.7 12.5 12 0 0 12 12 12 10 C2H2-type zinc finger KRAB PF01352.25 001346672.1_32926001_2 - 2e-20 72.1 0.1 3.2e-20 71.4 0.1 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 001346672.1_32926001_2 - 0.001 18.8 113.2 0.43 10.5 1.1 13.2 12 3 0 12 12 12 8 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001346672.1_32926001_2 - 0.0016 18.4 59.6 0.11 12.6 5.1 7.4 3 2 6 9 9 9 6 Zinc ribbon domain GATA PF00320.25 001346672.1_32926001_2 - 0.0032 16.9 33.7 1 8.9 0.2 8.7 9 0 0 9 9 9 2 GATA zinc finger DUF3268 PF11672.6 001346672.1_32926001_2 - 0.6 10.3 43.3 0.68 10.1 3.4 5.9 4 1 1 6 6 6 0 zinc-finger-containing domain Csm1 PF12539.6 001346672.1_32926001_2 - 3.3 8.3 6.6 38 4.9 0.1 4.6 3 1 2 6 6 6 0 Chromosome segregation protein Csm1/Pcs1 zf-H2C2_2 PF13465.4 001346672.1_32926001_3 - 8.3e-05 22.7 12.6 0.052 13.9 5.3 3.1 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.24 001346672.1_32926001_3 - 0.0046 17.2 15.6 0.13 12.7 5.5 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type DnaB PF00772.19 001346672.1_32926001_3 - 0.087 12.8 1.4 14 5.7 0.0 4.6 3 1 4 7 7 7 0 DnaB-like helicase N terminal domain Trypsin PF00089.24 001198928.2_22423001_1 - 2.1e-53 181.2 0.0 2.7e-53 180.9 0.0 1.1 1 0 0 1 1 1 1 Trypsin Syntaxin PF00804.23 001243828.2_49824001_2 - 0.055 13.0 0.8 0.076 12.5 0.8 1.1 1 0 0 1 1 1 0 Syntaxin GSHPx PF00255.17 001159298.2_29622001_2 - 4.2e-37 125.9 0.0 5.5e-37 125.5 0.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase Agouti PF05039.10 001159298.2_29622001_2 - 0.056 14.0 3.1 0.095 13.3 3.1 1.3 1 0 0 1 1 1 0 Agouti protein Pro_isomerase PF00160.19 001163049.2_39523001_3 - 7.4e-51 172.4 0.0 9.6e-51 172.1 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD EF-hand_1 PF00036.30 001163594.2_39523001_1 - 2.3e-29 98.6 16.7 3.1e-08 32.5 0.8 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 001163594.2_39523001_1 - 1.2e-26 92.8 8.8 1.7e-13 50.7 0.2 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 001163594.2_39523001_1 - 1.7e-22 77.3 9.9 2.1e-08 33.3 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.4 001163594.2_39523001_1 - 3.2e-21 74.7 11.7 5.5e-12 45.1 0.6 3.6 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.4 001163594.2_39523001_1 - 1.7e-16 60.2 0.2 2.3e-07 30.9 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.4 001163594.2_39523001_1 - 1.6e-13 49.4 16.0 4.6e-05 22.6 0.2 4.5 4 1 0 4 4 4 3 EF hand EF-hand_4 PF12763.5 001163594.2_39523001_1 - 0.00013 21.8 4.9 0.29 11.0 1.1 3.0 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SurA_N_3 PF13624.4 001163594.2_39523001_1 - 0.026 14.2 4.3 1.6 8.4 0.6 2.2 1 1 1 2 2 2 0 SurA N-terminal domain Sigma54_CBD PF04963.11 001163594.2_39523001_1 - 0.03 14.0 0.3 0.051 13.3 0.3 1.3 1 0 0 1 1 1 0 Sigma-54 factor, core binding domain EF-hand_11 PF08976.9 001163594.2_39523001_1 - 0.058 14.1 0.3 9.2 7.1 0.0 2.2 1 1 1 2 2 2 0 EF-hand domain SurA_N_2 PF13623.4 001163594.2_39523001_1 - 0.08 12.7 4.3 2.5 7.8 0.5 2.7 1 1 1 2 2 2 0 SurA N-terminal domain SPARC_Ca_bdg PF10591.7 001163594.2_39523001_1 - 0.083 13.1 2.7 1.9 8.7 1.0 2.2 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF853 PF05872.10 001163594.2_39523001_1 - 0.097 11.1 0.4 2.8 6.3 0.0 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF853) LETM1 PF07766.11 001163594.2_39523001_1 - 0.21 10.8 4.2 0.29 10.3 2.6 2.0 1 1 1 2 2 2 0 LETM1-like protein RRM_1 PF00076.20 001246198.2_49824001_3 - 1.3e-09 37.6 0.0 2.6e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TUDOR PF00567.22 001246198.2_49824001_3 - 3.6e-09 36.6 0.0 8.5e-09 35.3 0.0 1.6 2 0 0 2 2 2 1 Tudor domain RRM_7 PF16367.3 001246198.2_49824001_3 - 0.05 13.6 0.0 0.095 12.7 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif Ank_5 PF13857.4 213735.2_49822001_1 - 9.6e-06 25.7 0.4 2.1e-05 24.6 0.4 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.4 213735.2_49822001_1 - 1.1e-05 25.8 0.0 0.0079 16.6 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.28 213735.2_49822001_1 - 0.0069 16.7 0.1 0.044 14.1 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.5 213735.2_49822001_1 - 0.009 16.4 0.0 0.019 15.4 0.0 1.5 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) P19Arf_N PF07392.10 213735.2_49822001_3 - 6.9e-24 83.9 11.1 6.9e-24 83.9 11.1 1.8 2 0 0 2 2 2 1 Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus A_deaminase PF00962.20 214016.2_49825001_1 - 1.8e-23 83.3 0.0 2.9e-23 82.6 0.0 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase A_deaminase_N PF08451.9 214016.2_49825001_1 - 1.7e-15 57.0 0.2 3.1e-15 56.1 0.2 1.4 1 0 0 1 1 1 1 Adenosine/AMP deaminase N-terminal LRR_8 PF13855.4 001082219.1_37926001_3 - 2.9e-80 263.8 136.1 1.6e-14 53.2 6.4 11.7 5 5 9 14 14 14 14 Leucine rich repeat LRR_4 PF12799.5 001082219.1_37926001_3 - 2.9e-31 106.7 106.5 5.5e-05 23.3 4.7 13.6 9 2 5 14 14 14 13 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001082219.1_37926001_3 - 4.8e-25 87.9 24.7 2.2e-06 27.5 5.5 5.8 2 1 2 5 5 5 5 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001082219.1_37926001_3 - 6.2e-12 45.2 41.9 3.1e-06 26.7 1.0 7.3 1 1 7 8 8 8 8 Leucine-rich repeat TIR PF01582.18 001082219.1_37926001_3 - 1.2e-10 41.3 0.2 2.5e-10 40.3 0.2 1.5 1 0 0 1 1 1 1 TIR domain LRR_1 PF00560.31 001082219.1_37926001_3 - 1.5e-06 27.7 87.3 0.92 10.1 0.3 19.7 18 3 0 18 18 18 5 Leucine Rich Repeat LRRNT PF01462.16 001082219.1_37926001_3 - 0.0036 16.8 1.0 0.016 14.7 0.2 2.7 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain TIR_2 PF13676.4 001082219.1_37926001_3 - 0.04 14.1 0.0 0.078 13.2 0.0 1.4 1 0 0 1 1 1 0 TIR domain LRRCT PF01463.22 001082219.1_37926001_3 - 0.062 13.7 0.2 0.28 11.7 0.1 2.3 2 0 0 2 2 2 0 Leucine rich repeat C-terminal domain Interferon PF00143.17 001003923.1_49822001_1 - 1.2e-56 191.1 1.0 1.4e-56 190.9 1.0 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain SesA PF17107.3 001003923.1_49822001_1 - 0.017 15.2 0.0 0.027 14.5 0.0 1.3 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Nudc_N PF14050.4 001003923.1_49822001_1 - 0.52 10.2 2.2 2.5 8.0 0.3 2.5 2 0 0 2 2 2 0 N-terminal conserved domain of Nudc. LRR_8 PF13855.4 001082732.2_37926001_2 - 2.4e-45 152.0 63.1 4.8e-12 45.3 3.7 10.1 4 3 6 10 10 10 9 Leucine rich repeat TIR PF01582.18 001082732.2_37926001_2 - 1.7e-32 112.5 0.2 3e-32 111.7 0.2 1.3 1 0 0 1 1 1 1 TIR domain LRR_4 PF12799.5 001082732.2_37926001_2 - 2.7e-27 94.1 59.2 1.6e-05 25.0 1.4 11.1 4 2 9 14 14 14 11 Leucine Rich repeats (2 copies) TIR_2 PF13676.4 001082732.2_37926001_2 - 3.1e-09 37.0 0.1 5.4e-09 36.2 0.1 1.4 1 0 0 1 1 1 1 TIR domain LRR_1 PF00560.31 001082732.2_37926001_2 - 2e-08 33.4 54.4 2 9.1 0.1 13.8 13 2 0 13 13 13 4 Leucine Rich Repeat LRR_9 PF14580.4 001082732.2_37926001_2 - 2.5e-08 33.5 17.5 0.00038 19.9 0.1 5.2 2 2 3 5 5 5 4 Leucine-rich repeat LRR_6 PF13516.4 001082732.2_37926001_2 - 4.7e-07 29.2 56.1 0.58 10.2 0.1 13.8 14 0 0 14 14 14 6 Leucine Rich repeat DUF1863 PF08937.9 001082732.2_37926001_2 - 0.00013 22.1 0.1 0.0007 19.8 0.1 1.9 2 0 0 2 2 2 1 MTH538 TIR-like domain (DUF1863) Curto_V2 PF07325.9 001082732.2_37926001_2 - 0.15 11.8 0.3 0.36 10.6 0.3 1.6 1 0 0 1 1 1 0 Curtovirus V2 protein L_HMGIC_fpl PF10242.7 001265846.1_29623001_1 - 2.6e-56 190.6 14.6 3.3e-56 190.2 14.6 1.1 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein UPF0016 PF01169.17 001265846.1_29623001_1 - 0.0013 18.9 8.1 0.048 13.9 1.4 2.9 3 0 0 3 3 3 2 Uncharacterized protein family UPF0016 DUF2733 PF10813.6 037576.1_26224120_1 - 3.3 7.4 4.2 8.2 6.2 4.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2733) DUF778 PF05608.10 037576.1_26224120_3 - 5e-42 144.2 1.8 2.4e-20 73.5 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF778) DUF1129 PF06570.9 036541.1_26225120_1 - 1.1 8.6 4.6 2 7.8 4.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) ABA_GPCR PF12430.6 036541.1_26225120_3 - 6.6e-42 143.2 12.3 1e-41 142.5 12.3 1.3 1 0 0 1 1 1 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.6 036541.1_26225120_3 - 1.3e-28 98.7 0.4 3e-28 97.6 0.1 1.8 2 0 0 2 2 2 1 The Golgi pH Regulator (GPHR) Family N-terminal NPCC PF08058.9 036541.1_26225120_3 - 0.72 9.8 0.0 0.72 9.8 0.0 2.4 2 0 0 2 2 2 0 Nuclear pore complex component Choline_kinase PF01633.18 037153.1_32924120_1 - 1.6e-13 50.6 0.0 2.2e-13 50.2 0.0 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase Choline_kinase PF01633.18 037153.1_32924120_2 - 2.1e-53 180.9 0.0 5e-53 179.7 0.0 1.6 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.21 037153.1_32924120_2 - 3.2e-11 43.5 0.0 5.4e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.18 037153.1_32924120_2 - 0.0017 17.6 0.1 0.0027 16.9 0.1 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase TRAP-delta PF05404.10 037927.1_26222120_1 - 6e-65 217.6 0.0 7.4e-65 217.3 0.0 1.1 1 0 0 1 1 1 1 Translocon-associated protein, delta subunit precursor (TRAP-delta) Ribosomal_S27e PF01667.15 033727.1_32922120_2 - 7.6e-30 102.3 5.1 1e-29 101.8 5.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S27 AIF-MLS PF14962.4 028121.1_32923120_1 - 2.1e-11 44.0 1.3 2.6e-11 43.7 1.3 1.1 1 0 0 1 1 1 1 Mitochondria Localisation Sequence AIF-MLS PF14962.4 028121.1_32923120_2 - 8e-62 208.5 15.4 8e-62 208.5 15.4 2.1 1 1 1 2 2 2 1 Mitochondria Localisation Sequence Borrelia_P83 PF05262.9 028121.1_32923120_2 - 1.4 7.2 7.4 0.46 8.8 5.0 1.3 1 1 0 1 1 1 0 Borrelia P83/100 protein 4F5 PF04419.12 037672.1_26225120_3 - 6e-10 39.7 10.8 6e-10 39.7 10.8 2.4 2 0 0 2 2 2 1 4F5 protein family Ig_3 PF13927.4 072999.1_26229120_1 - 1.3e-20 73.6 1.7 1.3e-12 48.0 0.5 2.6 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 072999.1_26229120_1 - 2.6e-16 59.3 0.5 1.5e-09 37.7 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 072999.1_26229120_1 - 3.7e-16 58.9 0.9 6.1e-09 35.8 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 072999.1_26229120_1 - 1e-11 44.9 1.8 2.6e-06 27.5 0.3 2.4 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 072999.1_26229120_1 - 2.4e-11 43.6 1.8 7.5e-08 32.4 0.2 2.6 2 0 0 2 2 2 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 072999.1_26229120_1 - 0.0024 17.8 0.2 0.0081 16.1 0.2 1.8 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 072999.1_26229120_1 - 0.0062 16.4 0.2 0.52 10.3 0.0 2.4 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain Cauli_VI PF01693.14 104352.1_08023120_1 - 2.2e-19 69.3 1.2 4.4e-19 68.4 1.2 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin RNase_H PF00075.22 104352.1_08023120_1 - 3.2e-09 37.0 0.0 5e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 RNase H RNase_H PF00075.22 104352.1_08023120_3 - 2.4e-26 92.5 0.1 3.5e-26 92.0 0.1 1.2 1 0 0 1 1 1 1 RNase H Med24_N PF11277.6 052017.1_26228120_2 - 9e-47 159.6 1.6 1.2e-46 159.2 1.6 1.1 1 0 0 1 1 1 1 Mediator complex subunit 24 N-terminal Med24_N PF11277.6 052017.1_26228120_3 - 0 1115.9 6.7 0 1115.2 6.7 1.2 1 0 0 1 1 1 1 Mediator complex subunit 24 N-terminal DUF4752 PF15944.3 052017.1_26228120_3 - 0.16 11.9 0.0 14 5.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4752) Asparaginase_2 PF01112.16 110352.1_32925120_1 - 8.9e-39 133.2 0.1 1.5e-38 132.5 0.1 1.3 1 0 0 1 1 1 1 Asparaginase Tmemb_9 PF05434.9 109920.1_26224120_1 - 2.6e-14 53.2 0.6 4.1e-14 52.5 0.6 1.3 1 0 0 1 1 1 1 TMEM9 Tmemb_9 PF05434.9 109920.1_26224120_3 - 9.5e-32 109.7 0.0 1.4e-31 109.2 0.0 1.2 1 0 0 1 1 1 1 TMEM9 DUF2061 PF09834.7 110408.1_32922120_2 - 0.11 12.9 0.4 0.16 12.3 0.4 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2061) p450 PF00067.20 110408.1_32922120_3 - 5e-73 246.3 0.4 6.2e-73 246.0 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 ODC_AZ PF02100.15 125743.1_08025120_1 - 2.1e-19 69.4 0.0 4.1e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Cornichon PF03311.12 136295.1_26225120_3 - 3.4e-26 91.8 4.9 1.1e-25 90.2 4.9 1.8 1 1 0 1 1 1 1 Cornichon protein PRK PF00485.16 134667.1_26225120_2 - 2.3e-31 108.9 0.2 3.1e-31 108.5 0.2 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family PRK PF00485.16 134667.1_26225120_3 - 5.9e-08 32.5 0.0 1e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family Zeta_toxin PF06414.10 134667.1_26225120_3 - 0.0042 16.3 0.0 0.0066 15.6 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.4 134667.1_26225120_3 - 0.023 15.1 0.0 0.035 14.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain CoaE PF01121.18 134667.1_26225120_3 - 0.024 14.2 0.0 0.035 13.6 0.0 1.2 1 0 0 1 1 1 0 Dephospho-CoA kinase T2SSE PF00437.18 134667.1_26225120_3 - 0.12 11.2 0.0 0.18 10.7 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein LTXXQ PF07813.10 134667.1_26225120_3 - 0.18 12.4 0.0 0.31 11.7 0.0 1.3 1 0 0 1 1 1 0 LTXXQ motif family protein CLCA PF08434.9 130895.1_32928120_1 - 1.5e-154 515.6 0.0 1.8e-154 515.3 0.0 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel VWA_2 PF13519.4 130895.1_32928120_1 - 1.3e-12 48.2 0.2 2.2e-12 47.5 0.2 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.26 130895.1_32928120_1 - 2.5e-11 44.0 0.1 4e-11 43.3 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.12 130895.1_32928120_1 - 8e-05 22.0 0.0 0.00014 21.2 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein CLCA PF08434.9 130895.1_32928120_2 - 7e-165 549.8 0.4 9.2e-165 549.4 0.4 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel A2M_N PF01835.17 130895.1_32928120_2 - 0.00056 20.2 0.1 0.0016 18.7 0.0 1.7 2 0 0 2 2 2 1 MG2 domain Ion_trans_2 PF07885.14 133661.1_26223120_2 - 2.3e-11 43.4 0.4 3.7e-11 42.7 0.4 1.2 1 0 0 1 1 1 1 Ion channel Ion_trans_2 PF07885.14 133661.1_26223120_3 - 1.9e-18 66.1 1.6 2.3e-18 65.8 0.6 1.6 2 0 0 2 2 2 1 Ion channel Ion_trans PF00520.29 133661.1_26223120_3 - 2e-05 23.8 0.0 2.7e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Ion transport protein ODC_AZ PF02100.15 125741.1_08025120_2 - 2.3e-19 69.4 0.0 4.4e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme TIR PF01582.18 120680.1_49824120_2 - 3.9e-31 108.1 0.2 5.7e-31 107.5 0.2 1.1 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.4 120680.1_49824120_2 - 3e-06 27.3 0.0 5.8e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 TIR domain DUF1863 PF08937.9 120680.1_49824120_2 - 0.00014 22.1 0.1 0.00027 21.1 0.1 1.4 1 0 0 1 1 1 1 MTH538 TIR-like domain (DUF1863) LRR_8 PF13855.4 120680.1_49824120_3 - 1.5e-06 27.7 0.3 2.7e-06 26.9 0.3 1.3 1 0 0 1 1 1 1 Leucine rich repeat LRR_1 PF00560.31 120680.1_49824120_3 - 0.0053 16.9 0.7 0.19 12.2 0.6 3.3 3 0 0 3 3 3 1 Leucine Rich Repeat LRR_4 PF12799.5 120680.1_49824120_3 - 0.016 15.4 0.4 0.029 14.6 0.4 1.4 1 0 0 1 1 1 0 Leucine Rich repeats (2 copies) ODC_AZ PF02100.15 125744.1_08024120_3 - 2.1e-19 69.5 0.0 3.3e-19 68.9 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ODC_AZ PF02100.15 125742.1_08025120_1 - 2.2e-19 69.4 0.0 4.2e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Pkinase PF00069.23 145487.1_32926120_1 - 6.3e-33 114.1 0.0 3.3e-23 82.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 145487.1_32926120_1 - 4.1e-06 26.1 0.1 0.00034 19.9 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Haemolytic PF01809.16 145487.1_32926120_1 - 0.025 14.3 0.0 0.053 13.3 0.0 1.4 1 0 0 1 1 1 0 Haemolytic domain Pkinase PF00069.23 145487.1_32926120_2 - 2.4e-26 92.6 0.1 3.7e-26 91.9 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 145487.1_32926120_2 - 7.2e-12 45.0 0.0 1.3e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 145487.1_32926120_2 - 8.9e-05 21.8 0.0 0.00013 21.2 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 145487.1_32926120_2 - 0.0012 18.1 0.1 0.0018 17.5 0.1 1.1 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 145487.1_32926120_2 - 0.029 13.8 0.0 0.044 13.2 0.0 1.1 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.18 145487.1_32926120_2 - 0.076 12.5 0.1 0.14 11.6 0.1 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.21 145487.1_32926120_2 - 0.094 12.5 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.4 145487.1_32926120_2 - 0.16 11.5 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Prenyltrans PF00432.19 145513.1_49824120_1 - 1.6e-66 219.5 12.1 1.4e-15 56.6 0.1 6.5 6 1 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.4 145513.1_49824120_1 - 0.18 10.8 0.0 13 4.6 0.0 2.2 2 0 0 2 2 2 0 Squalene-hopene cyclase C-terminal domain Syntaxin-18_N PF10496.7 144414.1_26225120_1 - 7.7e-21 74.0 0.9 2.7e-20 72.3 0.0 2.3 2 0 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus Phage_Integr_2 PF13009.4 144414.1_26225120_1 - 0.035 13.1 1.0 0.051 12.5 1.0 1.2 1 0 0 1 1 1 0 Putative phage integrase DUF913 PF06025.10 144414.1_26225120_1 - 3.5 6.4 5.9 0.98 8.2 1.9 1.9 2 1 1 3 3 3 0 Domain of Unknown Function (DUF913) Endonuclease_5 PF04493.12 148042.1_26226120_1 - 1.7e-28 99.6 0.0 2.3e-28 99.1 0.0 1.1 1 0 0 1 1 1 1 Endonuclease V TMIE PF16038.3 148042.1_26226120_1 - 0.17 11.6 2.4 0.33 10.7 2.4 1.3 1 0 0 1 1 1 0 TMIE protein Endonuclease_5 PF04493.12 148042.1_26226120_2 - 0.00026 20.6 0.0 0.00042 19.9 0.0 1.2 1 0 0 1 1 1 1 Endonuclease V Endonuclease_5 PF04493.12 148043.1_26226120_2 - 2.4e-40 138.2 0.0 2e-34 118.9 0.0 2.2 1 1 1 2 2 2 2 Endonuclease V MotA_ExbB PF01618.14 148043.1_26226120_2 - 0.099 12.3 0.0 0.7 9.6 0.0 2.0 2 0 0 2 2 2 0 MotA/TolQ/ExbB proton channel family TMIE PF16038.3 148043.1_26226120_2 - 0.23 11.2 1.8 0.55 10.0 1.8 1.6 1 0 0 1 1 1 0 TMIE protein DSPc PF00782.18 002834.1_26225120_3 - 1.9e-27 95.6 0.0 2.9e-27 95.0 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 002834.1_26225120_3 - 0.049 13.1 0.1 0.075 12.5 0.1 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.10 002834.1_26225120_3 - 0.12 12.6 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Rit1 DUSP-like domain EF-hand_7 PF13499.4 015504.1_32923120_2 - 5.2e-05 23.5 0.1 0.00035 20.9 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.30 015504.1_32923120_2 - 0.00051 19.3 0.1 0.00097 18.4 0.1 1.4 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.4 015504.1_32923120_2 - 0.0011 18.5 0.1 0.0019 17.8 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.4 015504.1_32923120_2 - 0.0087 15.4 0.2 0.014 14.7 0.2 1.3 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.4 015504.1_32923120_2 - 0.015 15.1 0.1 0.033 14.0 0.1 1.4 1 0 0 1 1 1 0 EF-hand domain DUF2892 PF11127.6 028512.1_32921120_2 - 0.05 13.5 0.0 0.064 13.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2892) Guanylate_cyc PF00211.18 024042.1_26226120_1 - 1.9e-38 131.8 0.0 6.2e-37 126.9 0.0 2.5 2 1 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.12 024042.1_26226120_1 - 7.6e-05 22.1 0.4 0.00013 21.3 0.4 1.3 1 0 0 1 1 1 1 Heme NO binding associated Pkinase_Tyr PF07714.15 024042.1_26226120_1 - 0.006 15.8 0.0 2.5 7.2 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.23 024042.1_26226120_1 - 0.1 11.8 0.0 0.23 10.7 0.0 1.5 1 1 0 1 1 1 0 Protein kinase domain Transposase_22 PF02994.12 027039.1_26225120_1 - 8.1e-37 126.8 1.0 1.2e-36 126.3 1.0 1.1 1 0 0 1 1 1 1 L1 transposable element Inhibitor_I29 PF08246.10 027917.1_26222120_1 - 2.6e-05 24.4 0.2 4.6e-05 23.6 0.2 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1 PF00112.21 027917.1_26222120_1 - 0.042 13.8 0.2 0.088 12.8 0.1 1.7 2 0 0 2 2 2 0 Papain family cysteine protease Peptidase_C1 PF00112.21 027917.1_26222120_3 - 3.2e-05 24.0 0.1 4.4e-05 23.6 0.1 1.1 1 0 0 1 1 1 1 Papain family cysteine protease SYS1 PF09801.7 003189.2_26223120_1 - 3.2e-16 59.7 0.0 4.6e-16 59.2 0.0 1.1 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network Dysbindin PF04440.14 003189.2_26223120_2 - 5e-30 104.4 1.8 7.5e-30 103.9 1.8 1.2 1 0 0 1 1 1 1 Dysbindin (Dystrobrevin binding protein 1) PRIMA1 PF16101.3 003189.2_26223120_3 - 4.1 7.3 10.5 8.3 6.3 9.8 1.8 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 HisKA_3 PF07730.11 033777.1_26223120_3 - 1.1 9.7 3.5 23 5.5 0.1 2.4 2 0 0 2 2 2 0 Histidine kinase PyrBI_leader PF08052.9 027978.1_32923120_1 - 0.046 13.6 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 PyrBI operon leader peptide SPW PF03779.12 040483.1_32922120_1 - 0.068 12.7 0.2 0.12 11.8 0.2 1.3 1 0 0 1 1 1 0 SPW repeat DUF1725 PF08333.9 045446.1_32924120_3 - 1.9e-06 27.2 0.2 4.3e-06 26.1 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Drf_FH1 PF06346.10 027846.1_32925120_1 - 0.0046 16.5 1.5 0.011 15.3 1.5 1.6 1 0 0 1 1 1 1 Formin Homology Region 1 Lamp PF01299.15 045305.1_32923120_1 - 0.24 10.7 20.5 0.36 10.2 20.5 1.2 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) CobT_C PF11775.6 045305.1_32923120_1 - 0.35 10.4 1.4 0.48 9.9 1.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT VWA domain Shisa PF13908.4 045305.1_32923120_1 - 0.5 10.5 4.5 0.73 9.9 4.5 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Dicty_REP PF05086.10 045305.1_32923120_1 - 3.7 5.3 9.4 5.1 4.8 9.4 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF305 PF03713.11 045735.1_32923120_2 - 0.074 13.1 0.0 0.1 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF305) Pou PF00157.15 034180.1_26223120_2 - 1.3e-37 127.5 0.8 2.4e-37 126.7 0.8 1.4 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 034180.1_26223120_2 - 2e-16 59.4 0.2 2e-16 59.4 0.2 1.6 2 0 0 2 2 2 1 Homeobox domain DIL PF01843.17 034180.1_26223120_2 - 0.092 12.9 0.6 0.17 12.1 0.6 1.4 1 0 0 1 1 1 0 DIL domain Pkinase PF00069.23 028062.1_26229120_3 - 8.5e-63 212.0 0.0 1.3e-62 211.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 028062.1_26229120_3 - 1.5e-32 112.8 0.0 2.3e-32 112.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 028062.1_26229120_3 - 1.2e-05 24.6 0.0 2e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Rhabdo_NV PF02484.13 027085.1_26226120_1 - 0.064 13.3 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Rhabdovirus Non-virion protein GOLGA2L5 PF15070.4 033936.3_26227120_1 - 1.2e-08 34.0 0.1 1.9e-08 33.4 0.1 1.2 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 GOLGA2L5 PF15070.4 033936.3_26227120_2 - 5e-07 28.6 0.0 7.1e-07 28.2 0.0 1.1 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 GOLGA2L5 PF15070.4 033936.3_26227120_3 - 0.064 11.8 0.0 0.09 11.3 0.0 1.0 1 0 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 JMY PF15871.3 026589.1_26229120_1 - 1.4e-135 452.0 3.3 5.6e-77 259.3 0.0 2.1 2 0 0 2 2 2 2 Junction-mediating and -regulatory protein WHAMM-JMY_N PF15920.3 026589.1_26229120_1 - 4.7e-23 80.6 0.0 1e-22 79.6 0.0 1.6 1 0 0 1 1 1 1 N-terminal of Junction-mediating and WASP homolog-associated Phospho_p8 PF10195.7 046037.1_32923120_2 - 0.082 13.2 0.4 0.15 12.4 0.4 1.3 1 0 0 1 1 1 0 DNA-binding nuclear phosphoprotein p8 POC1 PF10450.7 073453.1_26223120_3 - 0.01 14.7 0.0 0.014 14.3 0.0 1.1 1 0 0 1 1 1 0 POC1 chaperone Ribosomal_L10 PF00466.18 002775.2_26228120_3 - 7.8e-16 57.9 0.0 1.9e-15 56.6 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.17 002775.2_26228120_3 - 1.4e-11 44.6 4.4 1.4e-11 44.6 4.4 2.9 3 0 0 3 3 3 1 60s Acidic ribosomal protein Glyco_hydro_42C PF08533.8 125718.1_26228120_3 - 0.024 14.2 0.2 0.042 13.4 0.2 1.4 1 0 0 1 1 1 0 Beta-galactosidase C-terminal domain zf-H2C2_2 PF13465.4 026777.2_26229120_1 - 6.8e-13 48.3 34.3 8.1e-05 22.8 2.5 7.1 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2 PF00096.24 026777.2_26229120_1 - 4.4e-05 23.6 48.7 0.01 16.1 0.9 6.8 6 0 0 6 6 6 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 026777.2_26229120_1 - 0.00018 21.9 43.4 0.18 12.6 0.5 6.9 6 0 0 6 6 6 4 C2H2-type zinc finger PHD PF00628.27 026777.2_26229120_1 - 0.00018 21.2 15.4 0.015 15.0 2.2 3.4 2 1 0 2 2 2 2 PHD-finger zf-C2H2_6 PF13912.4 026777.2_26229120_1 - 0.11 12.4 36.8 0.82 9.6 0.4 7.2 6 0 0 6 6 6 0 C2H2-type zinc finger KRAB PF01352.25 026777.2_26229120_2 - 1.1e-15 56.9 1.3 9.4e-15 53.9 1.3 2.2 1 1 0 1 1 1 1 KRAB box zf-C2H2 PF00096.24 026777.2_26229120_2 - 2.4e-06 27.6 29.1 0.002 18.4 5.6 7.2 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 026777.2_26229120_2 - 1.5e-05 25.1 1.3 1.5e-05 25.1 1.3 9.4 10 0 0 10 10 10 2 Zinc-finger double domain zf-H2C2_2 PF13465.4 026777.2_26229120_3 - 2.9e-14 52.6 42.2 6.1e-08 32.6 0.2 7.7 9 0 0 9 9 9 4 Zinc-finger double domain zf-C2H2 PF00096.24 026777.2_26229120_3 - 2.8e-11 43.1 20.6 5e-06 26.6 1.3 5.2 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 026777.2_26229120_3 - 1.7e-07 31.3 11.6 0.0012 19.4 1.2 5.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.4 026777.2_26229120_3 - 0.0068 16.2 0.9 0.0068 16.2 0.9 3.6 3 0 0 3 3 3 1 C2H2-type zinc finger Cu_bind_like PF02298.15 026777.2_26229120_3 - 0.03 14.2 0.2 0.076 12.9 0.2 1.6 1 0 0 1 1 1 0 Plastocyanin-like domain Zn-ribbon_8 PF09723.8 026777.2_26229120_3 - 0.24 11.4 8.1 0.44 10.6 1.8 2.7 2 0 0 2 2 2 0 Zinc ribbon domain zf-H2C2_5 PF13909.4 026777.2_26229120_3 - 0.7 9.6 7.2 1 9.0 1.7 3.3 2 0 0 2 2 2 0 C2H2-type zinc-finger domain C1_4 PF07975.10 026777.2_26229120_3 - 0.86 9.8 4.6 4.4 7.5 1.2 2.9 2 0 0 2 2 2 0 TFIIH C1-like domain zf-C2H2_jaz PF12171.6 026777.2_26229120_3 - 1.4 9.2 7.1 0.21 11.8 0.3 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.3 026777.2_26229120_3 - 1.9 8.9 9.5 17 5.9 2.2 3.3 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger PRR20 PF15708.3 134977.1_32926120_1 - 7.4e-15 55.4 11.3 1.3e-14 54.6 11.3 1.4 1 0 0 1 1 1 1 Proline-rich protein family 20 Hormone_1 PF00103.18 110935.1_08022120_1 - 1.1e-27 97.1 0.4 1.5e-27 96.7 0.4 1.2 1 0 0 1 1 1 1 Somatotropin hormone family Hormone_1 PF00103.18 110935.1_08022120_3 - 1.1e-06 28.4 1.0 1.4e-06 28.1 1.0 1.1 1 0 0 1 1 1 1 Somatotropin hormone family PRR20 PF15708.3 134979.1_32926120_1 - 6.9e-15 55.5 11.3 1.2e-14 54.7 11.3 1.4 1 0 0 1 1 1 1 Proline-rich protein family 20 IFT57 PF10498.7 136921.1_32922120_2 - 0.16 10.8 0.0 0.2 10.4 0.0 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 KRAB PF01352.25 136920.1_32926120_2 - 5.8e-19 67.4 0.2 9.1e-19 66.7 0.2 1.3 1 0 0 1 1 1 1 KRAB box IMUP PF15761.3 145437.1_26222120_2 - 0.27 11.8 12.1 0.48 11.0 12.1 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein SR-25 PF10500.7 145437.1_26222120_2 - 0.65 9.4 13.7 0.93 8.9 13.7 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Calcyon PF06387.9 001260971.2_29623001_1 - 6.8e-84 280.2 0.1 8.6e-84 279.9 0.1 1.1 1 0 0 1 1 1 1 D1 dopamine receptor-interacting protein (calcyon) RNB PF00773.17 001194471.2_29628001_3 - 1.3e-89 300.6 0.0 2.2e-89 299.9 0.0 1.4 1 0 0 1 1 1 1 RNB domain Rrp44_S1 PF17215.1 001194471.2_29628001_3 - 5.1e-08 32.6 0.0 2e-07 30.7 0.0 2.0 2 0 0 2 2 2 1 S1 domain Rrp44_CSD1 PF17216.1 001194471.2_29628001_3 - 1.5e-06 27.9 0.0 2.9e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Rrp44-like cold shock domain EF-hand_1 PF00036.30 001195420.2_29623001_1 - 6.5e-26 87.8 13.2 9.5e-07 27.8 0.3 4.7 5 0 0 5 5 5 4 EF hand EF-hand_5 PF13202.4 001195420.2_29623001_1 - 9.4e-23 78.5 7.9 3.4e-06 26.2 0.3 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 001195420.2_29623001_1 - 2.9e-22 78.8 2.3 2.1e-11 44.0 0.2 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 001195420.2_29623001_1 - 6.1e-21 72.4 6.8 8e-05 22.1 0.1 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.4 001195420.2_29623001_1 - 8.2e-16 57.4 9.0 0.0046 16.6 0.4 4.3 4 0 0 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.7 001195420.2_29623001_1 - 1e-06 28.9 0.0 0.023 14.9 0.0 2.7 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 001195420.2_29623001_1 - 0.00062 19.6 4.3 0.88 9.4 0.6 3.5 1 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.4 001195420.2_29623001_1 - 0.0018 18.4 0.1 0.038 14.2 0.0 2.6 3 0 0 3 3 3 1 EF-hand domain YtfJ_HI0045 PF09695.8 001195420.2_29623001_1 - 0.089 12.3 0.5 2 7.9 0.5 2.1 1 1 0 1 1 1 0 Bacterial protein of unknown function (YtfJ_HI0045) REV PF00424.16 001195420.2_29623001_3 - 1.3 9.0 4.8 1.2 9.0 0.2 2.3 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) SLC12 PF03522.13 001110839.2_39729001_2 - 2.5e-151 504.3 0.2 3.4e-151 503.8 0.2 1.2 1 0 0 1 1 1 1 Solute carrier family 12 AA_permease PF00324.19 001110839.2_39729001_2 - 7.3e-151 502.9 37.3 8.9e-151 502.6 37.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_N PF08403.8 001110839.2_39729001_2 - 4.9e-34 115.5 0.0 1.8e-32 110.5 0.1 2.5 2 0 0 2 2 2 1 Amino acid permease N-terminal AA_permease_2 PF13520.4 001110839.2_39729001_2 - 1.7e-20 73.1 43.7 2.8e-20 72.4 43.7 1.3 1 0 0 1 1 1 1 Amino acid permease zf-RING_2 PF13639.4 001251909.2_39726001_2 - 3.3e-10 39.9 6.0 1.1e-09 38.3 6.0 2.0 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 001251909.2_39726001_2 - 3.6e-10 39.4 6.0 1.1e-09 37.8 6.0 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001251909.2_39726001_2 - 9.8e-10 38.2 3.7 3.1e-09 36.6 3.7 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001251909.2_39726001_2 - 4.1e-09 36.0 6.6 9.7e-09 34.8 6.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001251909.2_39726001_2 - 5.7e-09 35.7 6.7 1.5e-08 34.3 6.7 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 001251909.2_39726001_2 - 1.1e-08 34.7 7.1 3.2e-08 33.2 7.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 001251909.2_39726001_2 - 0.00012 22.2 6.0 0.00034 20.7 6.0 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_4 PF14570.4 001251909.2_39726001_2 - 0.00015 21.3 5.2 0.00034 20.1 5.2 1.7 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.4 001251909.2_39726001_2 - 0.00018 21.1 11.4 0.00018 21.1 11.4 3.1 3 1 1 4 4 4 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.4 001251909.2_39726001_2 - 0.00047 20.1 7.2 0.0034 17.4 7.2 2.5 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-UDP PF14569.4 001251909.2_39726001_2 - 0.002 18.1 2.8 0.011 15.7 2.8 2.1 2 0 0 2 2 2 1 Zinc-binding RING-finger Rtf2 PF04641.10 001251909.2_39726001_2 - 0.0028 16.9 0.2 0.0048 16.2 0.2 1.3 1 0 0 1 1 1 1 Rtf2 RING-finger Zn_ribbon_17 PF17120.3 001251909.2_39726001_2 - 0.023 14.2 3.2 0.084 12.4 3.2 1.9 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.3 001251909.2_39726001_2 - 0.081 12.5 2.7 0.26 10.9 2.7 2.0 1 0 0 1 1 1 0 RING-like zinc finger DZR PF12773.5 001251909.2_39726001_2 - 0.1 12.5 3.3 0.36 10.8 3.3 2.0 1 0 0 1 1 1 0 Double zinc ribbon zf-RING_10 PF16685.3 001251909.2_39726001_2 - 0.13 12.3 5.5 0.29 11.2 5.5 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_6 PF14835.4 001251909.2_39726001_2 - 0.18 11.6 4.0 0.59 9.9 4.0 1.9 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Longin PF13774.4 001194575.2_29625001_1 - 7.9e-19 67.4 0.2 1.4e-18 66.6 0.2 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Lebercilin PF15619.4 001243973.2_39726001_2 - 1e-65 220.9 42.5 1e-65 220.9 42.5 2.3 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease DUF4551 PF15087.4 001194760.2_29624001_1 - 4.6e-180 600.4 22.1 1.7e-125 420.1 14.8 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF4551) KH_1 PF00013.27 001193921.2_29629001_1 - 3.4e-54 180.4 11.9 8e-13 47.9 0.1 4.4 4 0 0 4 4 4 4 KH domain KH_2 PF07650.15 001193921.2_29629001_1 - 6.6e-17 61.0 3.2 0.0031 17.2 0.1 4.4 4 0 0 4 4 4 4 KH domain RRM_1 PF00076.20 001193921.2_29629001_1 - 5.8e-16 57.9 0.0 1.4e-07 31.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_4 PF13083.4 001193921.2_29629001_1 - 8.4e-14 51.1 0.2 0.015 15.1 0.0 4.8 4 0 0 4 4 4 4 KH domain KH_5 PF13184.4 001193921.2_29629001_1 - 1.3e-06 28.3 4.6 1.1 9.3 0.1 4.1 4 0 0 4 4 4 3 NusA-like KH domain MOEP19 PF16005.3 001193921.2_29629001_1 - 8.6e-06 25.6 0.2 0.081 12.8 0.0 3.9 4 0 0 4 4 4 2 KH-like RNA-binding domain RRM_5 PF13893.4 001193921.2_29629001_1 - 0.0047 16.4 0.0 0.19 11.2 0.1 2.3 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001193921.2_29629001_1 - 0.017 14.9 0.0 0.12 12.1 0.0 2.4 2 0 0 2 2 2 0 Occluded RNA-recognition motif DUF4041 PF13250.4 001193921.2_29629001_1 - 0.028 14.2 0.2 0.068 12.9 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4041) Cadherin PF00028.15 001082588.2_39729001_3 - 2.8e-77 255.1 0.0 1.1e-21 76.9 0.0 6.4 6 0 0 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 001082588.2_39729001_3 - 3e-63 211.9 4.7 4.8e-63 211.3 4.7 1.3 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 001082588.2_39729001_3 - 9.7e-31 105.3 1.8 2.5e-28 97.6 0.1 4.1 4 0 0 4 4 4 1 Cadherin-like Cadherin_3 PF16184.3 001082588.2_39729001_3 - 1.3e-07 31.5 1.9 0.12 12.2 0.1 4.5 4 0 0 4 4 4 2 Cadherin-like Cadherin_C_2 PF16492.3 001082588.2_39729001_3 - 0.00022 21.8 0.1 0.00071 20.2 0.1 1.9 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal PRIMA1 PF16101.3 001202505.2_39727001_1 - 7.5 6.5 6.9 4.5 7.2 2.6 2.4 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Trypsin PF00089.24 001202505.2_39727001_2 - 3.3e-65 219.9 0.0 5.5e-65 219.1 0.0 1.4 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 001202505.2_39727001_2 - 6.5e-35 119.7 0.0 8.6e-21 74.2 0.1 2.5 2 0 0 2 2 2 2 CUB domain Ldl_recept_a PF00057.16 001202505.2_39727001_2 - 4.5e-34 116.2 66.6 1.2e-09 38.1 8.4 4.6 4 0 0 4 4 4 4 Low-density lipoprotein receptor domain class A SEA PF01390.18 001202505.2_39727001_2 - 1.6e-14 53.9 0.1 3e-14 53.1 0.1 1.4 1 0 0 1 1 1 1 SEA domain CUB_2 PF02408.18 001202505.2_39727001_2 - 6.2e-05 22.6 0.4 0.0002 21.0 0.4 1.8 1 0 0 1 1 1 1 CUB-like domain DUF1986 PF09342.9 001202505.2_39727001_2 - 0.0017 18.6 0.0 0.0038 17.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) DDE_1 PF03184.17 001243890.2_39725001_3 - 6e-34 117.0 0.1 9e-34 116.4 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.14 001243890.2_39725001_3 - 1.6e-19 69.6 0.0 2.9e-19 68.7 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.11 001243890.2_39725001_3 - 8.7e-11 41.2 1.3 1.9e-10 40.1 1.3 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain CENP-B_dimeris PF09026.8 001243890.2_39725001_3 - 5.9e-05 23.2 0.3 0.00013 22.2 0.3 1.5 1 0 0 1 1 1 1 Centromere protein B dimerisation domain HTH_23 PF13384.4 001243890.2_39725001_3 - 0.0075 15.9 0.0 0.068 12.9 0.0 2.5 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_1 PF01527.18 001243890.2_39725001_3 - 0.019 15.1 0.0 0.053 13.7 0.0 1.8 1 0 0 1 1 1 0 Transposase UPF0122 PF04297.12 001243890.2_39725001_3 - 0.086 12.9 0.2 0.23 11.6 0.2 1.7 1 0 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like HTH_28 PF13518.4 001243890.2_39725001_3 - 0.1 12.6 0.0 1.2 9.2 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain Forkhead PF00250.16 001198708.2_29624001_2 - 1.3e-39 134.2 0.1 2.2e-39 133.5 0.1 1.3 1 0 0 1 1 1 1 Forkhead domain DUF4482 PF14818.4 001194871.2_29629001_2 - 3.3e-55 186.6 14.8 3.3e-55 186.6 14.8 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF4482) EMI PF07546.11 001193776.2_29628001_3 - 1.6e-16 60.7 6.7 3.9e-16 59.4 6.7 1.7 1 0 0 1 1 1 1 EMI domain IncA PF04156.12 001193776.2_29628001_3 - 0.00019 21.2 23.2 0.013 15.1 7.3 3.6 3 0 0 3 3 3 2 IncA protein DUF1664 PF07889.10 001193776.2_29628001_3 - 0.0019 18.1 9.7 0.34 10.8 0.3 5.5 3 1 2 6 6 6 2 Protein of unknown function (DUF1664) Reo_sigmaC PF04582.10 001193776.2_29628001_3 - 0.012 14.9 10.8 2.2 7.5 7.7 4.0 3 1 1 4 4 4 0 Reovirus sigma C capsid protein Spc7 PF08317.9 001193776.2_29628001_3 - 0.017 13.9 10.9 0.059 12.1 1.4 3.9 3 1 1 4 4 4 0 Spc7 kinetochore protein DUF2730 PF10805.6 001193776.2_29628001_3 - 0.042 13.8 1.4 0.37 10.8 0.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2730) Lebercilin PF15619.4 001193776.2_29628001_3 - 0.068 12.7 12.1 0.13 11.7 1.6 3.4 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Yuri_gagarin PF15934.3 001193776.2_29628001_3 - 0.079 12.7 2.9 0.053 13.2 0.3 2.1 2 0 0 2 2 1 0 Yuri gagarin CorA PF01544.16 001193776.2_29628001_3 - 0.098 11.8 2.4 0.38 9.9 0.2 2.6 1 1 2 3 3 3 0 CorA-like Mg2+ transporter protein Transcrip_act PF04949.11 001193776.2_29628001_3 - 0.1 12.4 0.1 3.5 7.4 0.2 2.4 1 1 1 2 2 2 0 Transcriptional activator CHDCT2 PF08074.9 001193776.2_29628001_3 - 0.12 12.4 2.6 0.17 11.9 0.5 2.4 2 1 0 2 2 1 0 CHDCT2 (NUC038) domain FPP PF05911.9 001193776.2_29628001_3 - 0.23 9.6 3.4 1.7 6.6 1.0 2.3 2 0 0 2 2 2 0 Filament-like plant protein, long coiled-coil EzrA PF06160.10 001193776.2_29628001_3 - 0.24 9.4 0.2 0.51 8.3 0.2 1.5 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA BLOC1_2 PF10046.7 001193776.2_29628001_3 - 0.25 11.6 0.4 13 6.0 0.0 3.8 2 1 2 4 4 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TACC PF05010.12 001193776.2_29628001_3 - 0.41 10.3 1.8 8.5 6.0 0.1 3.0 2 1 1 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC) DUF4795 PF16043.3 001193776.2_29628001_3 - 0.42 10.0 2.1 7.3 6.0 0.8 3.3 3 1 0 3 3 2 0 Domain of unknown function (DUF4795) IFT57 PF10498.7 001193776.2_29628001_3 - 0.48 9.2 1.5 1.1 8.0 0.5 2.0 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Filament PF00038.19 001193776.2_29628001_3 - 0.49 9.8 8.2 0.44 9.9 0.8 3.3 2 1 1 3 3 3 0 Intermediate filament protein Laminin_II PF06009.10 001193776.2_29628001_3 - 0.49 10.3 4.2 6.2 6.7 0.6 3.3 2 1 1 3 3 2 0 Laminin Domain II DUF16 PF01519.14 001193776.2_29628001_3 - 0.51 10.7 5.0 0.37 11.2 0.6 2.9 2 1 1 3 3 3 0 Protein of unknown function DUF16 Golgin_A5 PF09787.7 001193776.2_29628001_3 - 0.56 9.5 11.7 0.02 14.2 2.8 2.7 3 0 0 3 3 3 0 Golgin subfamily A member 5 ATG16 PF08614.9 001193776.2_29628001_3 - 0.65 10.0 22.4 0.12 12.4 0.3 3.9 2 1 2 4 4 4 0 Autophagy protein 16 (ATG16) HMMR_C PF15908.3 001193776.2_29628001_3 - 0.76 9.9 2.2 13 5.9 0.2 2.9 3 0 0 3 3 3 0 Hyaluronan mediated motility receptor C-terminal DUF3450 PF11932.6 001193776.2_29628001_3 - 0.81 8.8 11.5 0.93 8.6 1.3 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF3450) Fez1 PF06818.13 001193776.2_29628001_3 - 0.81 10.0 9.6 0.49 10.7 2.9 3.2 2 1 1 3 3 3 0 Fez1 Rootletin PF15035.4 001193776.2_29628001_3 - 0.89 9.5 14.1 0.021 14.7 2.9 3.3 2 1 1 3 3 3 0 Ciliary rootlet component, centrosome cohesion SlyX PF04102.10 001193776.2_29628001_3 - 0.92 10.0 26.0 0.15 12.5 0.4 7.3 7 2 2 9 9 7 0 SlyX CALCOCO1 PF07888.9 001193776.2_29628001_3 - 1 7.7 14.5 0.11 11.0 7.9 2.1 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like NPV_P10 PF05531.10 001193776.2_29628001_3 - 1.4 9.3 8.9 9 6.7 0.0 5.1 4 2 1 5 5 3 0 Nucleopolyhedrovirus P10 protein COG2 PF06148.9 001193776.2_29628001_3 - 3.2 7.7 13.0 0.6 10.1 0.9 4.2 5 1 1 6 6 4 0 COG (conserved oligomeric Golgi) complex component, COG2 APG6 PF04111.10 001193776.2_29628001_3 - 3.3 6.9 6.5 7.7 5.7 3.3 2.8 2 1 1 3 3 3 0 Autophagy protein Apg6 Uso1_p115_C PF04871.11 001193776.2_29628001_3 - 3.8 7.8 13.1 0.47 10.7 0.5 4.2 3 1 2 5 5 5 0 Uso1 / p115 like vesicle tethering protein, C terminal region Jnk-SapK_ap_N PF09744.7 001193776.2_29628001_3 - 7 6.7 9.5 34 4.5 0.1 3.4 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 GAS PF13851.4 001193776.2_29628001_3 - 9.7 5.4 9.6 0.7 9.1 0.6 3.1 3 1 0 3 3 3 0 Growth-arrest specific micro-tubule binding p450 PF00067.20 001194543.2_29624001_1 - 1.6e-134 449.1 0.0 2e-134 448.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DnaJ PF00226.29 001204969.2_39725001_3 - 3.2e-19 68.7 0.0 7.4e-19 67.5 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain Fructosamin_kin PF03881.12 001194815.2_29624001_1 - 4.4e-71 239.3 0.0 5.6e-71 239.0 0.0 1.1 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.21 001194815.2_29624001_1 - 3e-12 46.8 0.0 5e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.20 001194815.2_29624001_1 - 0.0021 17.6 0.0 0.0064 16.0 0.0 1.7 2 0 0 2 2 2 1 RIO1 family 7tm_4 PF13853.4 001193723.2_29623001_3 - 6e-60 203.2 24.5 7.2e-60 202.9 24.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001193723.2_29623001_3 - 6e-25 87.9 22.9 6e-25 87.9 22.9 1.8 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) FAM196 PF15265.4 001193931.2_29628001_1 - 3e-169 564.5 11.6 3.5e-169 564.2 11.6 1.0 1 0 0 1 1 1 1 FAM196 family 7tm_4 PF13853.4 001194036.2_29623001_1 - 4.6e-47 160.9 19.3 6e-47 160.6 19.3 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001194036.2_29623001_1 - 1.1e-24 87.0 22.2 3.4e-24 85.4 22.2 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001194036.2_29623001_1 - 1.6e-07 30.9 17.8 3.2e-07 29.8 17.8 1.6 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Nop PF01798.16 001244674.2_39724001_3 - 2.1e-87 292.3 0.0 2.1e-87 292.3 0.0 1.7 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.11 001244674.2_39724001_3 - 1.2e-18 67.1 0.2 6.8e-18 64.6 0.2 2.5 1 0 0 1 1 1 1 NOP5NT (NUC127) domain Cytochrom_NNT PF03264.12 001244674.2_39724001_3 - 1.1 8.8 3.3 2.1 7.9 3.3 1.4 1 0 0 1 1 1 0 NapC/NirT cytochrome c family, N-terminal region SURF2 PF05477.9 001194794.2_29623001_2 - 7.6e-99 329.8 1.4 9.1e-99 329.6 1.4 1.0 1 0 0 1 1 1 1 Surfeit locus protein 2 (SURF2) p450 PF00067.20 001193803.2_29626001_1 - 1e-99 334.3 0.2 1.2e-99 334.0 0.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 WAC_Acf1_DNA_bd PF10537.7 001244159.2_49829001_1 - 3.3e-33 114.1 0.2 3.3e-33 114.1 0.2 3.0 3 0 0 3 3 3 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.4 001244159.2_49829001_1 - 8.1e-28 96.7 0.0 8.1e-28 96.7 0.0 4.9 4 1 0 4 4 4 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif Bromodomain PF00439.23 001244159.2_49829001_1 - 5.6e-20 71.1 0.3 1.4e-19 69.8 0.3 1.7 1 0 0 1 1 1 1 Bromodomain DDT PF02791.15 001244159.2_49829001_1 - 7.9e-14 51.6 2.6 7.9e-14 51.6 2.6 2.5 3 0 0 3 3 3 1 DDT domain PHD PF00628.27 001244159.2_49829001_1 - 1.5e-13 50.3 7.2 3.6e-13 49.0 7.2 1.7 1 0 0 1 1 1 1 PHD-finger WHIM1 PF15612.4 001244159.2_49829001_1 - 4.8e-10 38.6 0.0 1.6e-09 36.9 0.0 2.0 2 0 0 2 2 2 1 WSTF, HB1, Itc1p, MBD9 motif 1 Prok-RING_1 PF14446.4 001244159.2_49829001_1 - 0.12 12.2 3.2 0.36 10.6 3.2 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-RING_2 PF13639.4 001244159.2_49829001_1 - 0.64 10.2 6.7 1.5 9.0 6.7 1.7 1 0 0 1 1 1 0 Ring finger domain 7tm_4 PF13853.4 001194295.2_29622001_1 - 3.7e-56 190.8 14.8 4.6e-56 190.4 14.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001194295.2_29622001_1 - 1.7e-21 76.6 17.0 3.1e-21 75.7 17.0 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001194295.2_29622001_1 - 0.0021 17.4 16.1 0.0069 15.7 16.1 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx FtsX PF02687.19 001194295.2_29622001_1 - 0.4 10.5 9.0 0.067 13.0 0.9 2.5 2 0 0 2 2 2 0 FtsX-like permease family Cadherin PF00028.15 001082585.2_39729001_2 - 7.3e-80 263.4 0.0 1.7e-18 66.7 0.0 6.4 5 1 1 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 001082585.2_39729001_2 - 2e-63 212.5 4.7 3.6e-63 211.7 4.7 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 001082585.2_39729001_2 - 9.8e-32 108.5 2.3 2.5e-28 97.6 0.1 4.5 5 0 0 5 5 5 2 Cadherin-like Cadherin_C_2 PF16492.3 001082585.2_39729001_2 - 3.2e-06 27.7 0.3 1e-05 26.1 0.3 1.9 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001082585.2_39729001_2 - 0.00021 21.1 1.0 11 5.9 0.0 4.4 4 0 0 4 4 4 1 Cadherin-like ANP PF00212.16 001194397.2_29622001_2 - 3.9e-15 55.6 5.5 8.6e-15 54.5 5.5 1.6 1 0 0 1 1 1 1 Atrial natriuretic peptide DUF4813 PF16072.3 001194397.2_29622001_2 - 1.6 8.2 15.5 2.3 7.7 15.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) Folate_rec PF03024.12 001194647.2_29623001_3 - 4.8e-66 221.7 25.8 6.2e-66 221.4 25.8 1.1 1 0 0 1 1 1 1 Folate receptor family Tubulin PF00091.23 001194791.2_29624001_1 - 1.1e-68 231.3 0.0 1.6e-68 230.6 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 001194791.2_29624001_1 - 1e-42 145.2 0.1 1.6e-42 144.6 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.7 001194791.2_29624001_1 - 1.5e-05 25.2 0.0 3.5e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.4 001194791.2_29624001_1 - 0.0086 15.6 0.0 0.016 14.7 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.4 001194791.2_29624001_1 - 0.019 14.1 0.0 0.039 13.0 0.0 1.5 1 0 0 1 1 1 0 Tubulin like GSHPx PF00255.17 001243871.2_39723001_3 - 4.5e-34 116.1 0.0 7.2e-34 115.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.19 001243871.2_39723001_3 - 3.8e-06 26.7 0.0 6.7e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.8 001243871.2_39723001_3 - 0.018 14.6 0.0 0.03 13.9 0.0 1.3 1 0 0 1 1 1 0 Redoxin DUF1669 PF07894.10 001243845.2_39726001_1 - 8.6e-118 392.7 0.0 1.1e-117 392.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1669) PLDc_2 PF13091.4 001243845.2_39726001_1 - 3.2e-09 36.6 0.0 9.3e-09 35.1 0.1 1.7 2 0 0 2 2 2 1 PLD-like domain 7tm_4 PF13853.4 001194292.2_29622001_1 - 9.7e-42 143.5 19.5 1.4e-41 143.0 19.5 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001194292.2_29622001_1 - 1.8e-25 89.6 21.5 3.8e-25 88.5 21.5 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001194292.2_29622001_1 - 2.9e-05 23.5 11.7 2.9e-05 23.5 11.7 2.5 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx PHO4 PF01384.18 001193854.2_29627001_1 - 1.5e-137 458.0 2.4 2e-137 457.6 2.4 1.2 1 0 0 1 1 1 1 Phosphate transporter family LBP_BPI_CETP PF01273.23 001243275.2_29622001_1 - 4.1e-29 101.2 4.9 4.1e-29 101.2 4.9 1.7 1 1 1 2 2 2 1 LBP / BPI / CETP family, N-terminal domain AI-2E_transport PF01594.14 001243275.2_29622001_1 - 0.19 10.7 2.2 3.2 6.7 0.2 2.1 2 0 0 2 2 2 0 AI-2E family transporter Cadherin PF00028.15 001194885.2_29626001_1 - 9.4e-70 231.0 0.4 2.8e-18 66.0 0.0 6.2 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001194885.2_29626001_1 - 6.7e-37 125.0 2.7 2.1e-34 117.0 0.2 3.1 4 0 0 4 4 4 2 Cadherin-like Cadherin_C_2 PF16492.3 001194885.2_29626001_1 - 8.1e-28 96.9 0.4 1.8e-27 95.8 0.4 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001194885.2_29626001_1 - 6.8e-09 35.6 2.5 0.0086 15.9 0.1 4.6 4 0 0 4 4 4 4 Cadherin-like STAT_bind PF02864.13 001278347.2_29629001_2 - 1.5e-100 336.0 3.2 1.5e-100 336.0 3.2 2.1 2 0 0 2 2 2 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 001278347.2_29629001_2 - 2.1e-54 184.0 19.3 3.7e-54 183.2 19.3 1.4 1 0 0 1 1 1 1 STAT protein, all-alpha domain STAT_int PF02865.15 001278347.2_29629001_2 - 1.2e-31 109.6 4.0 1.2e-31 109.6 4.0 2.4 3 0 0 3 3 3 1 STAT protein, protein interaction domain SH2 PF00017.22 001278347.2_29629001_2 - 3.5e-11 42.9 0.3 1.7e-10 40.6 0.0 2.3 3 0 0 3 3 3 1 SH2 domain DUF4477 PF14780.4 001251850.2_39729001_3 - 2.5e-65 219.5 5.5 4.4e-65 218.7 5.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4477) RNase_PH PF01138.19 001251892.2_39723001_3 - 2.7e-24 86.0 0.0 7.7e-24 84.5 0.0 1.7 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.13 001251892.2_39723001_3 - 1.2e-12 47.5 0.1 2.9e-12 46.3 0.1 1.7 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Amino_oxidase PF01593.22 001190970.2_29622001_1 - 2.2e-29 102.9 0.0 3e-29 102.5 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.4 001190970.2_29622001_1 - 1.5e-13 50.7 2.0 4.8e-13 49.0 1.4 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 001190970.2_29622001_1 - 0.0023 17.5 1.2 0.0029 17.2 1.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.12 001190970.2_29622001_1 - 0.028 13.6 0.2 0.14 11.3 0.7 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 001190970.2_29622001_1 - 0.094 11.6 1.9 0.13 11.2 1.9 1.2 1 0 0 1 1 1 0 FAD binding domain AlaDh_PNT_C PF01262.19 001190970.2_29622001_1 - 0.12 11.5 1.1 0.18 10.9 1.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain UDPGT PF00201.16 001194387.2_29625001_3 - 2.8e-225 748.7 0.3 3.3e-225 748.5 0.3 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001194387.2_29625001_3 - 1.9e-05 24.6 0.0 3.1e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Pro_3_hydrox_C PF05373.9 001194387.2_29625001_3 - 0.017 15.1 0.2 0.041 13.8 0.2 1.6 1 0 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal Glyco_trans_1_3 PF13528.4 001194387.2_29625001_3 - 0.051 12.7 0.0 7.9 5.5 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase family 1 Ribosomal_L50 PF10501.7 001194797.2_29622001_2 - 6.1e-09 35.9 0.0 8.6e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal subunit 39S ESPR PF13018.4 001194797.2_29622001_3 - 0.06 13.0 0.4 0.11 12.1 0.4 1.4 1 0 0 1 1 1 0 Extended Signal Peptide of Type V secretion system Ephrin_rec_like PF07699.11 001194030.2_29629001_1 - 1.3e-05 24.8 85.1 0.001 18.6 9.1 8.1 5 3 3 8 8 8 6 Putative ephrin-receptor like NCD3G PF07562.12 001194030.2_29629001_1 - 0.026 14.4 65.2 0.019 14.8 7.8 7.6 6 1 1 7 7 7 0 Nine Cysteines Domain of family 3 GPCR PDZ PF00595.22 001243124.2_39722001_2 - 6.1e-22 77.6 0.1 9e-22 77.1 0.1 1.2 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001243124.2_39722001_2 - 3.2e-08 33.7 0.1 4.2e-08 33.3 0.1 1.2 1 0 0 1 1 1 1 PDZ domain TRAPP PF04051.14 001194478.2_29622001_2 - 2e-35 121.5 0.0 2.9e-35 121.0 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component G-patch PF01585.21 001194478.2_29622001_2 - 0.12 12.1 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 G-patch domain Ferlin_C PF16165.3 001318033.2_24229001_3 - 1.6e-69 232.6 0.2 2.4e-69 232.0 0.2 1.3 1 0 0 1 1 1 1 Ferlin C-terminus C2 PF00168.28 001318033.2_24229001_3 - 9.7e-64 212.0 0.0 8.8e-18 64.4 0.0 8.1 7 1 0 7 7 7 5 C2 domain FerB PF08150.10 001318033.2_24229001_3 - 1.3e-24 86.5 0.0 4.1e-24 84.9 0.0 1.9 2 0 0 2 2 2 1 FerB (NUC096) domain FerI PF08151.10 001318033.2_24229001_3 - 8.1e-15 54.5 0.0 1.7e-14 53.5 0.0 1.6 1 0 0 1 1 1 1 FerI (NUC094) domain DUF2628 PF10947.6 001318033.2_24229001_3 - 0.025 14.8 0.0 0.049 13.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2628) LZ_Tnp_IS66 PF13007.5 001318033.2_24229001_3 - 0.59 10.8 4.7 0.82 10.4 0.4 3.3 2 0 0 2 2 2 0 Transposase C of IS166 homeodomain NYD-SP28 PF14772.4 001194281.2_29625001_2 - 8e-29 99.5 10.5 8e-29 99.5 10.5 4.8 3 2 2 5 5 5 2 Sperm tail 7tm_3 PF00003.20 001099459.2_45726001_1 - 5.8e-58 196.3 26.6 5.8e-58 196.3 26.6 1.8 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.26 001099459.2_45726001_1 - 2.1e-35 122.3 1.5 4e-35 121.4 1.5 1.4 1 1 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.12 001099459.2_45726001_1 - 2.2e-17 62.6 12.5 6.3e-17 61.2 12.5 1.9 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR NUDIX_2 PF13869.4 001194254.2_29622001_1 - 0.04 13.3 0.9 0.93 8.9 0.1 2.2 1 1 1 2 2 2 0 Nucleotide hydrolase VIR_N PF15912.3 001193848.2_29629001_2 - 5e-101 337.6 28.5 5e-101 337.6 28.5 1.8 1 1 1 2 2 2 1 Virilizer, N-terminal Mpp10 PF04006.10 001193848.2_29629001_2 - 0.15 10.4 18.1 0.26 9.5 18.1 1.3 1 0 0 1 1 1 0 Mpp10 protein DUF4431 PF14485.4 001193848.2_29629001_3 - 0.12 12.0 1.6 0.26 11.0 1.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4431) Mab-21 PF03281.12 001194095.2_29629001_2 - 4.1e-16 59.0 0.0 4.6e-15 55.6 0.0 2.0 1 1 0 1 1 1 1 Mab-21 protein Complex1_LYR PF05347.13 001194095.2_29629001_2 - 4.9e-12 45.6 3.4 9.1e-12 44.7 3.4 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.4 001194095.2_29629001_2 - 5.2e-05 23.8 1.7 9.5e-05 22.9 1.7 1.4 1 0 0 1 1 1 1 Complex1_LYR-like Forkhead PF00250.16 001194519.2_29624001_3 - 1.8e-36 124.1 0.2 2.7e-36 123.6 0.2 1.2 1 0 0 1 1 1 1 Forkhead domain Forkhead_N PF08430.10 001194519.2_29624001_3 - 9.2e-05 22.9 2.1 9.2e-05 22.9 2.1 2.5 2 1 0 2 2 2 1 Forkhead N-terminal region HNF_C PF09354.8 001194519.2_29624001_3 - 0.00033 21.5 0.0 0.0012 19.7 0.0 2.0 1 0 0 1 1 1 1 HNF3 C-terminal domain fn3 PF00041.19 001194600.2_29623001_1 - 0.0039 17.4 0.0 0.0071 16.5 0.0 1.3 1 0 0 1 1 1 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 001194600.2_29623001_1 - 0.043 14.2 0.0 0.081 13.4 0.0 1.4 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain 7tm_4 PF13853.4 001194029.2_29622001_3 - 2.1e-47 162.1 18.4 2.5e-47 161.8 18.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001194029.2_29622001_3 - 3.4e-21 75.5 19.3 7.6e-21 74.4 19.3 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001194029.2_29622001_3 - 0.052 12.8 18.3 0.28 10.4 18.3 1.9 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001194029.2_29622001_3 - 0.16 11.1 14.0 2 7.5 14.0 2.3 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx Chibby PF14645.4 001194744.2_29622001_3 - 1.7e-35 121.8 0.1 2.5e-35 121.2 0.1 1.2 1 0 0 1 1 1 1 Chibby family zf-H2C2_2 PF13465.4 001251860.2_39723001_1 - 1.3e-39 132.8 54.4 2.7e-07 30.6 0.5 8.8 9 0 0 9 9 9 7 Zinc-finger double domain zf-C2H2 PF00096.24 001251860.2_39723001_1 - 2.5e-30 103.1 67.4 7.1e-06 26.1 1.4 8.2 8 0 0 8 8 7 7 Zinc finger, C2H2 type KRAB PF01352.25 001251860.2_39723001_1 - 2.2e-24 84.7 0.1 5.3e-24 83.5 0.1 1.7 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 001251860.2_39723001_1 - 1.3e-15 56.5 62.5 0.00058 20.3 4.3 8.2 8 0 0 8 8 7 6 C2H2-type zinc finger FYVE PF01363.19 001251860.2_39723001_1 - 0.00046 20.1 27.8 0.02 14.9 0.1 4.4 1 1 2 3 3 3 2 FYVE zinc finger XPA_N PF01286.16 001251860.2_39723001_1 - 0.016 15.1 31.0 3 7.8 0.1 7.4 7 0 0 7 7 7 0 XPA protein N-terminal DUF3268 PF11672.6 001251860.2_39723001_1 - 0.034 14.3 18.1 0.12 12.6 0.4 3.7 2 1 0 3 3 3 0 zinc-finger-containing domain zf-C2H2_11 PF16622.3 001251860.2_39723001_1 - 0.05 13.2 35.3 0.056 13.1 1.9 6.8 7 0 0 7 7 7 0 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 001251860.2_39723001_1 - 0.15 11.9 0.3 0.15 11.9 0.3 8.2 8 0 0 8 8 7 0 C2H2-type zinc finger Chordopox_RPO7 PF05864.10 001251860.2_39723001_1 - 0.24 11.6 6.5 2.3 8.4 0.0 4.3 4 1 0 4 4 4 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Zn-ribbon_8 PF09723.8 001251860.2_39723001_1 - 1.6 8.8 42.4 0.38 10.8 5.9 6.4 4 2 4 8 8 8 0 Zinc ribbon domain BolA PF01722.16 001251860.2_39723001_1 - 2.8 8.1 6.8 51 4.1 0.1 3.4 2 1 1 3 3 3 0 BolA-like protein LIM PF00412.20 001251860.2_39723001_1 - 3.6 7.7 33.8 1.3 9.1 0.1 6.9 4 2 2 6 6 6 0 LIM domain DZR PF12773.5 001251860.2_39723001_1 - 4.8 7.2 35.7 7.5e+02 0.1 0.1 5.6 2 1 0 2 2 1 0 Double zinc ribbon CYTH PF01928.19 001194442.2_29625001_3 - 1.7e-38 132.2 0.0 2.5e-38 131.6 0.0 1.2 1 0 0 1 1 1 1 CYTH domain CHD5 PF04420.12 001251919.2_39724001_3 - 5.9e-33 113.8 1.0 8.2e-33 113.4 1.0 1.2 1 0 0 1 1 1 1 CHD5-like protein DUF1043 PF06295.10 001251919.2_39724001_3 - 0.0076 16.1 1.8 0.012 15.5 1.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1043) DUF2203 PF09969.7 001251919.2_39724001_3 - 0.012 16.3 0.4 0.35 11.5 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF2868 PF11067.6 001251919.2_39724001_3 - 0.064 12.6 0.1 0.43 9.9 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2868) eIF_4EBP PF05456.9 001204096.2_29622001_1 - 1.9e-37 127.6 0.5 2.6e-37 127.1 0.5 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) TRAF_BIRC3_bd PF16673.3 001194792.2_29625001_1 - 3e-31 106.9 4.5 6.8e-31 105.7 4.5 1.6 1 0 0 1 1 1 1 TNF receptor-associated factor BIRC3 binding domain zf-TRAF PF02176.16 001194792.2_29625001_1 - 1.4e-20 73.6 30.0 8e-19 68.0 11.5 2.9 2 0 0 2 2 2 2 TRAF-type zinc finger Reo_sigmaC PF04582.10 001194792.2_29625001_1 - 6.4e-05 22.4 0.2 9.1e-05 21.9 0.2 1.1 1 0 0 1 1 1 1 Reovirus sigma C capsid protein MATH PF00917.24 001194792.2_29625001_1 - 0.019 15.0 0.0 0.035 14.1 0.0 1.4 1 0 0 1 1 1 0 MATH domain DUF1664 PF07889.10 001194792.2_29625001_1 - 0.39 10.6 1.5 0.64 9.9 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) SlyX PF04102.10 001194792.2_29625001_1 - 1.1 9.8 7.8 0.38 11.3 1.2 2.9 2 1 1 3 3 3 0 SlyX ATP_bind_3 PF01171.18 001194705.2_29623001_3 - 3.7e-17 62.5 0.0 1e-16 61.1 0.0 1.6 1 1 0 1 1 1 1 PP-loop family zn-ribbon_14 PF16503.3 001194705.2_29623001_3 - 5.9e-13 47.9 4.5 5.9e-13 47.9 4.5 3.5 4 0 0 4 4 4 1 Zinc-ribbon tRNA_Me_trans PF03054.14 001194705.2_29623001_3 - 0.0018 17.0 0.0 0.0024 16.6 0.0 1.1 1 0 0 1 1 1 1 tRNA methyl transferase RecR PF02132.13 001194705.2_29623001_3 - 0.043 13.3 0.5 0.043 13.3 0.5 2.5 3 0 0 3 3 3 0 RecR protein DUF4821 PF16092.3 001193937.2_29629001_1 - 8.8e-99 330.3 6.1 8e-94 314.0 0.2 2.8 2 1 0 2 2 2 2 Domain of unknown function (DUF4821) Pyr_redox_2 PF07992.12 001193937.2_29629001_1 - 0.0038 16.4 0.0 0.031 13.4 0.0 2.2 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase PMP22_Claudin PF00822.18 001194741.2_29622001_1 - 1.3e-05 25.0 2.4 1.7e-05 24.6 2.4 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family FragX_IP PF05994.9 001194296.2_29629001_3 - 0 1318.9 0.1 0 1318.9 0.1 1.4 2 0 0 2 2 2 1 Cytoplasmic Fragile-X interacting family DUF1394 PF07159.10 001194296.2_29629001_3 - 1.5e-08 34.2 5.9 1.5e-08 34.2 5.9 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1394) Lipocalin PF00061.21 001193934.2_29622001_2 - 1.3e-15 57.7 0.0 1.6e-15 57.5 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_2 PF08212.10 001193934.2_29622001_2 - 0.19 11.5 0.0 0.39 10.5 0.0 1.6 1 1 0 1 1 1 0 Lipocalin-like domain CRAL_TRIO_2 PF13716.4 001243105.2_39726001_1 - 8.1e-07 29.1 0.1 1.7e-06 28.1 0.1 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Spectrin PF00435.19 001243105.2_39726001_1 - 4.4e-06 27.0 20.0 0.0014 19.0 0.4 5.0 4 1 1 5 5 5 2 Spectrin repeat H2O2_YaaD PF03883.12 001243105.2_39726001_1 - 0.071 12.5 0.9 0.47 9.8 0.6 2.3 1 1 1 2 2 2 0 Peroxide stress protein YaaA DUF781 PF05612.10 001194318.2_29623001_1 - 1.5e-79 267.5 0.2 1.9e-79 267.1 0.2 1.1 1 0 0 1 1 1 1 Mouse protein of unknown function (DUF781) F-box-like PF12937.5 001160298.2_29629001_1 - 6.7e-09 35.4 1.8 6.7e-09 35.4 1.8 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.31 001160298.2_29629001_1 - 2.5e-07 30.3 2.1 5.6e-07 29.2 2.1 1.6 1 0 0 1 1 1 1 F-box domain MIT PF04212.16 001160298.2_29629001_1 - 0.0012 18.7 0.1 0.0023 17.8 0.1 1.4 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain TPR_1 PF00515.26 001160298.2_29629001_1 - 0.16 11.8 0.1 0.33 10.7 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.15 001160298.2_29629001_1 - 0.16 12.0 0.7 0.71 10.0 0.4 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat PAP2 PF01569.19 001198707.2_29626001_1 - 6e-17 61.6 4.6 1.1e-16 60.7 4.6 1.4 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.4 001198707.2_29626001_1 - 0.00027 20.6 7.3 0.00027 20.6 7.3 1.9 2 1 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.4 001198707.2_29626001_1 - 0.0036 17.6 3.7 0.0098 16.3 1.7 2.6 2 0 0 2 2 2 1 PAP2 superfamily C-terminal GDE_N PF12439.6 001198707.2_29626001_3 - 0.069 12.4 0.0 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 Glycogen debranching enzyme N terminal FAM196 PF15265.4 001193840.2_29629001_3 - 9.7e-216 717.8 11.8 1.3e-215 717.4 11.8 1.2 1 0 0 1 1 1 1 FAM196 family CaM-KIIN PF15170.4 001193366.2_29621001_1 - 2.4e-46 155.7 0.0 2.7e-46 155.5 0.0 1.0 1 0 0 1 1 1 1 Calcium/calmodulin-dependent protein kinase II inhibitor 7tm_4 PF13853.4 001194208.2_29623001_2 - 2.6e-48 165.0 21.2 3.1e-48 164.8 21.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001194208.2_29623001_2 - 3.7e-20 72.1 21.8 8.9e-20 70.9 21.8 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001194208.2_29623001_2 - 0.01 15.1 21.0 0.034 13.4 21.0 1.8 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx Calsarcin PF05556.9 001194428.2_29623001_2 - 9.1e-34 116.9 0.0 1.8e-33 115.9 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-binding protein (Calsarcin) LSR PF05624.12 001194846.2_29624001_2 - 3.7e-24 84.3 35.8 6.4e-24 83.6 35.8 1.4 1 0 0 1 1 1 1 Lipolysis stimulated receptor (LSR) V-set PF07686.15 001194846.2_29624001_2 - 1.1e-06 28.6 0.1 0.00095 19.2 0.1 2.6 1 1 0 1 1 1 1 Immunoglobulin V-set domain p450 PF00067.20 001193738.2_29624001_1 - 1.8e-105 353.2 0.0 2.3e-105 352.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SWIM PF04434.15 001251838.2_39724001_3 - 8.9e-07 28.3 0.7 1.9e-06 27.3 0.7 1.5 1 0 0 1 1 1 1 SWIM zinc finger MULE PF10551.7 001251838.2_39724001_3 - 0.018 15.4 0.0 0.044 14.2 0.0 1.7 1 0 0 1 1 1 0 MULE transposase domain 7tm_4 PF13853.4 001194579.2_29622001_1 - 6.6e-47 160.4 23.9 8.1e-47 160.1 23.9 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001194579.2_29622001_1 - 1.9e-16 60.0 26.2 3.7e-16 59.0 26.2 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF872 PF05915.10 001194579.2_29622001_1 - 8.6 6.5 7.7 20 5.3 2.2 2.5 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) TLD PF07534.14 001194085.2_29622001_1 - 2.6e-36 124.8 0.1 3.1e-36 124.5 0.1 1.1 1 0 0 1 1 1 1 TLD Protamine_P2 PF00841.17 001009084.1_39722001_2 - 7.4e-35 119.2 40.2 7.4e-35 119.2 40.2 2.0 1 1 1 2 2 2 1 Sperm histone P2 TLV_coat PF00429.17 001304541.1_24224001_1 - 2.4e-69 234.4 8.0 9.5e-69 232.4 7.4 1.8 1 1 1 2 2 2 2 ENV polyprotein (coat polyprotein) TLV_coat PF00429.17 001304539.1_39726001_2 - 1.5e-68 231.8 6.9 3.4e-68 230.6 6.6 1.6 1 1 1 2 2 2 2 ENV polyprotein (coat polyprotein) Tim44 PF04280.13 001193896.2_29623001_2 - 0.012 15.6 0.1 0.027 14.5 0.1 1.5 1 0 0 1 1 1 0 Tim44-like domain MBA1 PF07961.9 001193896.2_29623001_2 - 0.049 12.5 0.1 0.077 11.9 0.1 1.2 1 0 0 1 1 1 0 MBA1-like protein AAA PF00004.27 001194119.2_29625001_3 - 2.1e-39 134.8 0.0 3.9e-39 134.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.8 001194119.2_29625001_3 - 3.1e-09 36.6 1.1 2.3e-08 33.8 0.0 2.9 4 0 0 4 4 3 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.10 001194119.2_29625001_3 - 2.8e-05 23.4 0.0 5e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.4 001194119.2_29625001_3 - 4.1e-05 23.6 0.0 7.3e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.12 001194119.2_29625001_3 - 5e-05 23.3 0.0 8.3e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.4 001194119.2_29625001_3 - 0.00016 21.9 0.2 0.067 13.4 0.1 2.6 2 1 0 2 2 2 1 AAA ATPase domain TIP49 PF06068.11 001194119.2_29625001_3 - 0.00044 19.2 0.0 0.00067 18.6 0.0 1.2 1 0 0 1 1 1 1 TIP49 C-terminus AAA_5 PF07728.12 001194119.2_29625001_3 - 0.00054 19.8 0.3 0.0025 17.7 0.3 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.19 001194119.2_29625001_3 - 0.0012 18.1 0.2 0.0022 17.3 0.2 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TsaE PF02367.15 001194119.2_29625001_3 - 0.0026 17.6 0.0 0.0046 16.8 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.15 001194119.2_29625001_3 - 0.0039 16.8 0.0 0.0079 15.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.4 001194119.2_29625001_3 - 0.0043 16.9 0.0 0.0099 15.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.4 001194119.2_29625001_3 - 0.01 16.0 0.6 0.073 13.2 0.3 2.5 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.4 001194119.2_29625001_3 - 0.019 15.3 0.4 0.068 13.6 0.4 2.0 1 1 0 1 1 1 0 AAA domain TPR_8 PF13181.4 001194119.2_29625001_3 - 0.035 14.2 0.3 3.2 8.1 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat AAA_24 PF13479.4 001194119.2_29625001_3 - 0.035 13.7 0.1 0.49 10.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain NACHT PF05729.10 001194119.2_29625001_3 - 0.068 12.9 0.1 0.16 11.7 0.1 1.6 1 0 0 1 1 1 0 NACHT domain ATPase PF06745.11 001194119.2_29625001_3 - 0.069 12.4 0.2 3.3 6.9 0.1 2.3 1 1 1 2 2 2 0 KaiC PhoH PF02562.14 001194119.2_29625001_3 - 0.083 12.2 0.1 0.14 11.5 0.1 1.2 1 0 0 1 1 1 0 PhoH-like protein AAA_28 PF13521.4 001194119.2_29625001_3 - 0.086 12.9 0.1 0.18 11.9 0.1 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.20 001194119.2_29625001_3 - 0.13 12.6 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_17 PF13207.4 001194119.2_29625001_3 - 0.13 12.6 0.1 0.39 11.0 0.1 1.8 1 0 0 1 1 1 0 AAA domain Glyco_transf_49 PF13896.4 001194482.2_29625001_3 - 5.2e-102 341.4 0.0 6.2e-102 341.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl-transferase for dystroglycan CD225 PF04505.10 001194828.2_29623001_3 - 6.2e-18 64.6 1.5 1.1e-17 63.7 1.5 1.4 1 0 0 1 1 1 1 Interferon-induced transmembrane protein AWPM-19 PF05512.9 001194828.2_29623001_3 - 0.2 11.7 3.1 0.34 11.0 3.1 1.3 1 0 0 1 1 1 0 AWPM-19-like family mTERF PF02536.12 001193943.2_29624001_2 - 5e-24 84.7 7.5 7.4e-24 84.2 7.5 1.3 1 0 0 1 1 1 1 mTERF PLDc_2 PF13091.4 001194399.2_29625001_1 - 1.9e-12 47.1 0.0 5.5e-05 22.9 0.0 2.6 2 1 0 2 2 2 2 PLD-like domain PLDc PF00614.20 001194399.2_29625001_1 - 0.012 15.6 0.1 0.85 9.8 0.1 2.7 2 0 0 2 2 2 0 Phospholipase D Active site motif Tuberin PF03542.14 001285553.1_09029001_1 - 2e-133 444.8 2.9 6.1e-133 443.2 2.9 1.9 1 1 0 1 1 1 1 Tuberin DUF3384 PF11864.6 001285553.1_09029001_1 - 1.2e-96 324.4 8.2 8.1e-96 321.7 8.2 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.13 001285553.1_09029001_1 - 4.3e-43 146.9 0.0 8.4e-43 146.0 0.0 1.4 1 0 0 1 1 1 1 Rap/ran-GAP Cnd1 PF12717.5 001285553.1_09029001_1 - 0.11 12.3 3.4 0.18 11.6 0.1 2.9 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Telomere_reg-2 PF10193.7 001285553.1_09029001_1 - 0.45 10.8 4.2 0.53 10.6 0.4 3.2 3 0 0 3 3 3 0 Telomere length regulation protein HEAT PF02985.20 001285553.1_09029001_1 - 0.61 10.4 2.1 8.2 6.8 0.0 3.9 4 0 0 4 4 4 0 HEAT repeat Reticulon PF02453.15 001100760.1_45726001_3 - 0.18 11.6 4.8 0.68 9.7 3.9 2.0 1 1 1 2 2 2 0 Reticulon Hamartin PF04388.10 001131085.1_43529001_1 - 1.3e-298 992.6 0.0 1.3e-298 992.6 0.0 2.2 2 0 0 2 2 2 1 Hamartin protein Hamartin PF04388.10 001314283.1_09027001_1 - 6.4e-291 967.2 0.0 6.4e-291 967.2 0.0 2.1 2 0 0 2 2 2 1 Hamartin protein DUF1664 PF07889.10 001314283.1_09027001_1 - 6.7 6.6 17.0 0.23 11.3 6.9 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Bacillus_HBL PF05791.9 001314283.1_09027001_1 - 9.4 5.8 21.3 0.016 14.8 8.0 2.3 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) FXMRP1_C_core PF12235.6 001290248.1_22422001_1 - 2.8 8.4 6.4 4.9 7.7 6.4 1.4 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal Ank_5 PF13857.4 001290248.1_22422001_2 - 6.3e-12 45.4 3.5 6e-05 23.2 0.6 3.6 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 001290248.1_22422001_2 - 1.2e-10 41.5 0.1 0.0098 16.3 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 001290248.1_22422001_2 - 2e-08 34.6 0.0 0.0037 17.7 0.0 2.1 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 001290248.1_22422001_2 - 4.2e-06 26.8 0.3 0.019 15.3 0.0 3.5 3 1 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.4 001290248.1_22422001_2 - 0.0034 17.6 0.2 5.5 7.8 0.0 3.5 4 0 0 4 4 4 1 Ankyrin repeat zf-H2C2_2 PF13465.4 001170577.1_45729001_3 - 7.8e-79 256.7 70.5 7.1e-09 35.6 0.1 13.8 13 0 0 13 13 13 12 Zinc-finger double domain zf-C2H2 PF00096.24 001170577.1_45729001_3 - 2.4e-48 159.8 90.9 2.6e-06 27.4 1.5 13.1 13 0 0 13 13 12 10 Zinc finger, C2H2 type SCAN PF02023.15 001170577.1_45729001_3 - 1.5e-39 133.6 5.6 2.8e-39 132.7 5.6 1.5 1 0 0 1 1 1 1 SCAN domain zf-C2H2_4 PF13894.4 001170577.1_45729001_3 - 2.3e-27 93.2 78.6 0.014 16.0 0.2 12.5 11 0 0 11 11 11 10 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001170577.1_45729001_3 - 5.7e-13 48.3 57.1 0.0047 16.7 0.5 10.9 10 0 0 10 10 10 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001170577.1_45729001_3 - 3.8e-05 23.6 54.8 0.011 15.7 1.5 7.1 3 1 5 9 9 9 7 Zinc ribbon domain zf-C2H2_jaz PF12171.6 001170577.1_45729001_3 - 0.0061 16.7 45.3 11 6.3 1.0 10.5 10 0 0 10 10 10 2 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 001170577.1_45729001_3 - 0.02 14.8 61.0 4 7.4 0.5 11.3 11 0 0 11 11 11 0 XPA protein N-terminal zinc_ribbon_15 PF17032.3 001170577.1_45729001_3 - 0.064 13.9 39.8 2.2 8.9 1.2 6.1 2 2 3 5 5 5 0 zinc-ribbon family C1_4 PF07975.10 001170577.1_45729001_3 - 1.1 9.5 53.2 1 9.5 0.4 8.3 5 1 3 9 9 8 0 TFIIH C1-like domain zf-C2H2_11 PF16622.3 001170577.1_45729001_3 - 4.5 7.0 46.8 5.9 6.6 0.8 9.2 9 0 0 9 9 9 0 zinc-finger C2H2-type GCV_H PF01597.17 001082720.1_37922001_1 - 5e-50 168.3 0.2 6e-50 168.1 0.2 1.0 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.20 001082720.1_37922001_1 - 0.1 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Biotin-requiring enzyme YqjK PF13997.4 001082720.1_37922001_3 - 0.11 12.6 1.1 0.17 12.0 1.1 1.3 1 0 0 1 1 1 0 YqjK-like protein TilS PF09179.9 001082720.1_37922001_3 - 0.14 12.5 2.7 9.6 6.7 0.5 2.2 2 0 0 2 2 2 0 TilS substrate binding domain Apolipoprotein PF01442.16 001082643.1_37923001_2 - 9.9e-51 172.3 16.7 1.8e-50 171.4 16.7 1.4 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain ApoLp-III PF07464.9 001082643.1_37923001_2 - 3.1e-07 30.5 4.1 0.0032 17.4 0.1 2.3 2 0 0 2 2 2 2 Apolipophorin-III precursor (apoLp-III) DUF883 PF05957.11 001082643.1_37923001_2 - 0.0075 16.7 25.0 0.17 12.3 2.3 4.4 1 1 3 4 4 4 1 Bacterial protein of unknown function (DUF883) Baculo_PEP_C PF04513.10 001082643.1_37923001_2 - 0.012 15.5 1.2 10 6.1 0.0 3.2 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus YtxH PF12732.5 001082643.1_37923001_2 - 0.016 15.6 5.5 0.37 11.2 0.1 3.8 3 2 0 3 3 3 0 YtxH-like protein DUF948 PF06103.9 001082643.1_37923001_2 - 0.17 12.1 0.6 6.9 6.9 0.2 2.8 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Fzo_mitofusin PF04799.11 001082643.1_37923001_2 - 0.18 11.2 8.3 0.37 10.2 3.3 2.8 2 1 1 3 3 3 0 fzo-like conserved region Exonuc_VII_L PF02601.13 001082643.1_37923001_2 - 0.22 10.9 12.6 52 3.1 12.6 2.1 1 1 0 1 1 1 0 Exonuclease VII, large subunit Phasin PF05597.9 001082643.1_37923001_2 - 0.81 9.6 11.8 0.42 10.5 0.8 3.4 1 1 3 4 4 4 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Phage_Mu_Gam PF07352.10 001082643.1_37923001_2 - 0.81 9.4 7.9 8.6 6.1 0.3 2.8 2 1 1 3 3 3 0 Bacteriophage Mu Gam like protein FAM184 PF15665.3 001082643.1_37923001_2 - 0.96 9.1 15.4 0.99 9.0 6.8 2.3 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B DUF1690 PF07956.9 001082643.1_37923001_2 - 1 9.6 12.4 2.3 8.5 5.7 2.5 2 1 1 3 3 3 0 Protein of Unknown function (DUF1690) TipAS PF07739.11 001082643.1_37923001_2 - 4.1 7.8 10.9 1.1 9.7 0.9 3.3 2 2 0 2 2 2 0 TipAS antibiotic-recognition domain DUF1640 PF07798.9 001082643.1_37923001_2 - 7.7 6.4 12.6 8.4 6.3 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1640) SPR1 PF15356.4 001045505.1_39721001_1 - 1.5e-52 176.8 57.8 1.7e-52 176.6 57.8 1.0 1 0 0 1 1 1 1 Psoriasis susceptibility locus 2 DUF1151 PF06625.9 001098574.1_39724001_2 - 3.7e-39 133.1 17.3 4.8e-39 132.7 17.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1151) KIAA1328 PF15369.4 001098574.1_39724001_2 - 0.67 9.6 10.6 1 9.0 10.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein KIAA1328 7tm_1 PF00001.19 001172737.1_09923001_1 - 6.1e-64 215.7 0.0 7.9e-64 215.3 0.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001172737.1_09923001_1 - 2.3e-05 23.8 10.2 0.0031 16.8 4.5 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001172737.1_09923001_1 - 0.00078 19.1 2.9 0.00094 18.9 1.4 1.7 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001172737.1_09923001_1 - 0.00091 18.5 7.2 0.00091 18.5 7.2 2.5 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF2238 PF09997.7 001172737.1_09923001_1 - 0.036 13.7 1.5 0.071 12.8 1.5 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2238) DUF621 PF04789.13 001172737.1_09923001_1 - 0.26 10.3 8.5 0.48 9.4 8.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF621) Ras PF00071.20 001161875.1_39522001_1 - 1.1e-58 197.3 0.0 1.3e-58 197.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001161875.1_39522001_1 - 1.5e-23 83.2 0.0 2e-23 82.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001161875.1_39522001_1 - 3.4e-10 39.5 0.0 6.3e-10 38.7 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001161875.1_39522001_1 - 0.00023 20.6 0.0 0.00044 19.7 0.0 1.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.8 001161875.1_39522001_1 - 0.033 13.5 0.0 0.055 12.8 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.10 001161875.1_39522001_1 - 0.036 13.3 0.0 0.049 12.8 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region GCV_H PF01597.17 026572.3_32923001_3 - 4.3e-49 165.3 0.4 5.6e-49 165.0 0.4 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein Nop25 PF09805.7 001193831.2_29623001_2 - 1.2e-15 58.1 13.8 1.2e-15 58.1 13.8 2.2 1 1 0 2 2 2 1 Nucleolar protein 12 (25kDa) DUF2357 PF09823.7 001193831.2_29623001_2 - 1.9 7.5 9.2 0.14 11.2 2.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF2357) Mnd1 PF03962.13 001193831.2_29623001_2 - 8.1 6.1 11.8 0.3 10.8 5.7 1.6 2 0 0 2 2 2 0 Mnd1 family Homeobox PF00046.27 152568.3_26224001_2 - 0.022 14.5 3.9 0.039 13.6 3.9 1.4 1 0 0 1 1 1 0 Homeobox domain Reticulon PF02453.15 001283174.1_29524001_3 - 0.0001 22.2 4.8 0.00017 21.4 4.8 1.3 1 0 0 1 1 1 1 Reticulon 7tm_1 PF00001.19 001277168.1_39524001_1 - 1.5e-49 168.5 15.1 1.5e-49 168.5 15.1 2.0 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) CXCR4_N PF12109.6 001277168.1_39524001_1 - 1.2e-15 57.3 3.1 1.8e-15 56.7 3.1 1.3 1 0 0 1 1 1 1 CXCR4 Chemokine receptor N terminal 7TM_GPCR_Srsx PF10320.7 001277168.1_39524001_1 - 3.2e-06 26.6 13.2 5.2e-06 25.9 13.2 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Pkinase_Tyr PF07714.15 001114280.1_49824001_1 - 5.1e-61 206.1 0.0 8.6e-61 205.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001114280.1_49824001_1 - 1e-55 188.8 0.2 2.8e-55 187.4 0.0 1.8 3 0 0 3 3 3 1 Protein kinase domain APH PF01636.21 001114280.1_49824001_1 - 0.0031 17.3 0.2 0.0076 16.1 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Mnd1 PF03962.13 001114280.1_49824001_1 - 0.31 10.8 13.1 0.53 10.0 7.8 2.3 2 0 0 2 2 2 0 Mnd1 family DUF4605 PF15378.4 001193924.1_29622001_1 - 3.3e-24 84.4 7.4 4.8e-24 83.9 7.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4605) Nucleoplasmin PF03066.13 001251976.1_39723001_1 - 4.2e-47 158.7 0.0 7.1e-47 158.0 0.0 1.4 1 0 0 1 1 1 1 Nucleoplasmin/nucleophosmin domain NPM1-C PF16276.3 001251976.1_39723001_1 - 6.6e-34 115.5 0.9 6.6e-34 115.5 0.9 1.9 2 0 0 2 2 2 1 Nucleophosmin C-terminal domain YL1 PF05764.11 001251976.1_39723001_1 - 8.7e-05 22.6 12.1 0.00012 22.2 12.1 1.3 1 0 0 1 1 1 1 YL1 nuclear protein SDA1 PF05285.10 001251976.1_39723001_1 - 0.0027 17.1 15.7 0.0038 16.6 15.7 1.1 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.10 001251976.1_39723001_1 - 0.015 13.4 19.2 0.021 12.9 19.2 1.1 1 0 0 1 1 1 0 Nop14-like family TFIIF_alpha PF05793.10 001251976.1_39723001_1 - 0.13 10.7 25.5 0.19 10.2 25.5 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CDC45 PF02724.12 001251976.1_39723001_1 - 0.73 7.9 16.3 1 7.5 16.3 1.1 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.10 001251976.1_39723001_1 - 1.1 8.4 20.1 0.34 10.1 17.1 1.6 2 0 0 2 2 2 0 NOA36 protein DNA_pol_phi PF04931.11 001251976.1_39723001_1 - 1.1 7.1 23.9 1.6 6.6 23.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi SAPS PF04499.13 001251976.1_39723001_1 - 1.8 7.1 7.5 2.2 6.8 7.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Hid1 PF12722.5 001251976.1_39723001_1 - 5.8 4.7 6.6 7.6 4.4 6.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GRASP55_65 PF04495.12 027343.1_32925120_3 - 5.7e-68 227.4 0.0 2.5e-53 180.0 0.0 2.2 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.4 027343.1_32925120_3 - 1.5e-05 25.0 0.0 0.11 12.7 0.0 2.5 2 0 0 2 2 2 2 PDZ domain DCAF17 PF15802.3 028482.1_26229120_1 - 1.1e-96 324.3 0.1 1.5e-96 323.9 0.1 1.1 1 0 0 1 1 1 1 DDB1- and CUL4-associated factor 17 DCAF17 PF15802.3 028482.1_26229120_3 - 4.8e-104 348.5 1.0 6.3e-104 348.2 1.0 1.1 1 0 0 1 1 1 1 DDB1- and CUL4-associated factor 17 dNK PF01712.17 136156.1_26229120_3 - 7.6e-27 94.4 0.1 1.8e-25 89.9 0.0 2.1 2 0 0 2 2 2 2 Deoxynucleoside kinase Transket_pyr PF02779.22 134945.1_26228120_1 - 4e-31 107.9 0.0 5.5e-31 107.5 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.18 134945.1_26228120_2 - 6.9e-35 119.5 0.0 9.6e-35 119.0 0.0 1.2 1 0 0 1 1 1 1 Transketolase, C-terminal domain Transket_pyr PF02779.22 134945.1_26228120_2 - 0.00078 19.0 0.0 0.0012 18.4 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain DUF4605 PF15378.4 001243959.1_39726001_2 - 6.8e-24 83.4 7.5 1.3e-23 82.5 7.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4605) ETC_C1_NDUFA4 PF04800.10 001279722.1_24222001_1 - 8.1e-39 131.6 1.9 8.1e-39 131.6 1.9 1.7 2 0 0 2 2 2 1 ETC complex I subunit conserved region DUF1775 PF07987.9 001279722.1_24222001_1 - 0.046 13.8 1.2 1.5 8.9 0.0 2.3 1 1 0 2 2 2 0 Domain of unkown function (DUF1775) Aldedh PF00171.20 001279612.1_24224001_1 - 4.5e-163 542.9 0.8 5.1e-163 542.7 0.8 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family SPATA6 PF14909.4 148448.1_26227120_2 - 2.7e-17 63.1 0.0 4.3e-17 62.4 0.0 1.3 1 0 0 1 1 1 1 Spermatogenesis-assoc protein 6 SPATA6 PF14909.4 148448.1_26227120_3 - 5.1e-14 52.5 0.0 7.8e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 Spermatogenesis-assoc protein 6 CLN5 PF15014.4 001082595.1_39523001_1 - 1.6e-174 579.6 6.7 1.8e-174 579.3 6.7 1.0 1 0 0 1 1 1 1 Ceroid-lipofuscinosis neuronal protein 5 Ca_hom_mod PF14798.4 001194517.1_29623001_1 - 1.5e-88 296.0 9.9 1.8e-88 295.8 9.9 1.1 1 0 0 1 1 1 1 Calcium homeostasis modulator DUF843 PF05814.9 001194517.1_29623001_1 - 0.15 11.9 0.3 0.44 10.4 0.0 1.8 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF843) PMT_4TMC PF16192.3 148397.1_26226120_2 - 2.1e-51 174.2 8.4 2.9e-51 173.8 8.4 1.2 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.17 148397.1_26226120_2 - 1.6e-09 37.7 0.0 2.6e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 MIR domain PMT PF02366.16 148397.1_26226120_3 - 2.9e-71 239.8 22.5 4.2e-71 239.3 22.5 1.1 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT PF02366.16 148392.1_26226120_2 - 5e-96 320.9 20.5 5e-96 320.9 20.5 1.6 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.3 148392.1_26226120_2 - 2.9e-51 173.8 8.4 2.9e-51 173.8 8.4 2.1 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.17 148392.1_26226120_2 - 5.3e-15 55.6 0.0 8.1e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 MIR domain PMT PF02366.16 148399.1_26227120_2 - 8e-97 323.5 23.6 1.1e-96 323.1 23.6 1.2 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.17 148399.1_26227120_2 - 3.7e-12 46.3 0.1 6.4e-12 45.6 0.1 1.2 1 0 0 1 1 1 1 MIR domain PMT_4TMC PF16192.3 148399.1_26227120_3 - 2.3e-51 174.1 8.4 3.4e-51 173.5 8.4 1.3 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase Cu_amine_oxidN2 PF02727.14 033180.1_45723120_1 - 2.3e-25 88.5 0.0 3.9e-25 87.8 0.0 1.4 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxid PF01179.18 033180.1_45723120_1 - 0.17 10.6 0.0 0.23 10.2 0.0 1.1 1 0 0 1 1 1 0 Copper amine oxidase, enzyme domain Cu_amine_oxid PF01179.18 033180.1_45723120_3 - 1.8e-08 33.6 0.0 8.7e-08 31.3 0.0 1.8 1 1 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.14 033180.1_45723120_3 - 0.048 13.9 0.0 0.077 13.3 0.0 1.3 1 0 0 1 1 1 0 Copper amine oxidase, N3 domain MBT PF02820.16 135092.1_26227120_1 - 4.3e-49 164.6 0.0 1.8e-25 88.9 0.0 2.4 2 0 0 2 2 2 2 mbt repeat SLED PF12140.6 135092.1_26227120_1 - 2.9e-36 124.2 0.1 5.3e-36 123.4 0.1 1.5 1 0 0 1 1 1 1 SLED domain SAM_1 PF00536.28 135092.1_26227120_1 - 1.1e-16 60.9 0.1 1.8e-16 60.2 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RBR PF17208.1 135092.1_26227120_1 - 4.9e-13 49.5 17.6 1.4e-12 48.0 17.6 1.9 1 0 0 1 1 1 1 RNA binding Region SAM_2 PF07647.15 135092.1_26227120_1 - 1.5e-07 31.3 0.0 2.8e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 135092.1_26227120_1 - 0.00089 19.1 0.0 0.0024 17.7 0.0 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Plectin PF00681.18 135092.1_26227120_3 - 0.078 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Plectin repeat MBT PF02820.16 001283580.1_29525001_3 - 7.2e-50 167.1 0.0 1.1e-25 89.6 0.0 2.4 2 0 0 2 2 2 2 mbt repeat SLED PF12140.6 001283580.1_29525001_3 - 1.8e-36 124.9 0.1 3e-36 124.2 0.1 1.4 1 0 0 1 1 1 1 SLED domain SAM_1 PF00536.28 001283580.1_29525001_3 - 1.7e-15 57.1 0.1 3.1e-15 56.2 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RBR PF17208.1 001283580.1_29525001_3 - 2.8e-13 50.3 17.6 8.8e-13 48.7 17.6 2.0 1 0 0 1 1 1 1 RNA binding Region SAM_2 PF07647.15 001283580.1_29525001_3 - 1.4e-06 28.2 0.0 2.9e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 001283580.1_29525001_3 - 0.00089 19.0 0.0 0.0018 18.1 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain MBT PF02820.16 001261359.1_29626001_2 - 3.3e-51 171.4 0.0 9.4e-26 89.8 0.0 2.4 2 0 0 2 2 2 2 mbt repeat SLED PF12140.6 001261359.1_29626001_2 - 2.4e-36 124.5 0.0 4.9e-36 123.5 0.0 1.6 1 0 0 1 1 1 1 SLED domain SAM_1 PF00536.28 001261359.1_29626001_2 - 3.1e-17 62.6 0.1 5.1e-17 61.9 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RBR PF17208.1 001261359.1_29626001_2 - 9.5e-11 42.1 11.0 9.5e-11 42.1 11.0 2.3 2 0 0 2 2 2 1 RNA binding Region SAM_PNT PF02198.14 001261359.1_29626001_2 - 0.00028 20.7 0.0 0.00057 19.7 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_2 PF07647.15 001261359.1_29626001_2 - 0.02 14.8 0.0 0.038 14.0 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Sof1 PF04158.12 015420.6_26226001_2 - 2e-33 114.3 12.0 3.3e-33 113.7 12.0 1.3 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.30 015420.6_26226001_2 - 3e-21 75.2 10.5 0.00074 20.2 0.0 6.3 7 0 0 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.9 015420.6_26226001_2 - 2.6e-06 27.3 0.5 0.00018 21.3 0.0 3.1 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.5 015420.6_26226001_2 - 2.1e-05 24.6 0.0 0.066 13.4 0.0 3.8 3 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Pkinase PF00069.23 214319.1_49825001_3 - 2.6e-55 187.5 0.1 5.3e-55 186.5 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 214319.1_49825001_3 - 1.5e-34 119.3 0.0 3.3e-34 118.2 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase dsrm PF00035.24 214319.1_49825001_3 - 2.8e-25 88.6 4.6 1.6e-12 47.8 0.5 2.9 2 0 0 2 2 2 2 Double-stranded RNA binding motif DND1_DSRM PF14709.5 214319.1_49825001_3 - 4.4e-05 23.5 1.0 0.04 14.1 0.0 3.0 2 1 0 2 2 2 2 double strand RNA binding domain from DEAD END PROTEIN 1 Kdo PF06293.12 214319.1_49825001_3 - 0.013 14.8 0.0 0.022 14.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.14 214319.1_49825001_3 - 0.035 14.1 0.0 0.074 13.1 0.0 1.4 1 0 0 1 1 1 0 ABC1 family Dicer_dimer PF03368.12 214319.1_49825001_3 - 0.12 12.5 1.3 0.65 10.1 0.0 2.7 2 1 0 2 2 2 0 Dicer dimerisation domain MOEP19 PF16005.3 001168936.1_40421001_1 - 3.4e-26 91.0 0.0 4.6e-26 90.5 0.0 1.1 1 0 0 1 1 1 1 KH-like RNA-binding domain MOEP19 PF16005.3 001257908.1_29622001_3 - 1.1e-25 89.3 0.0 1.6e-25 88.8 0.0 1.2 1 0 0 1 1 1 1 KH-like RNA-binding domain Selenoprotein_S PF06936.9 001348210.1_29623001_1 - 3.1e-95 317.4 2.4 4.1e-95 317.0 2.4 1.1 1 0 0 1 1 1 1 Selenoprotein S (SelS) LCD1 PF09798.7 001348210.1_29623001_1 - 7.3 4.8 7.2 9.6 4.4 7.2 1.0 1 0 0 1 1 1 0 DNA damage checkpoint protein Miga PF10265.7 001168982.1_40424001_1 - 1.9e-222 739.9 0.0 2.2e-222 739.7 0.0 1.0 1 0 0 1 1 1 1 Mitoguardin DUF3824 PF12868.5 001168982.1_40424001_1 - 0.18 12.3 0.4 0.36 11.4 0.4 1.4 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) APOBEC_N PF08210.9 001345936.1_40422001_3 - 1.6e-33 116.0 0.4 2e-33 115.7 0.4 1.1 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001345936.1_40422001_3 - 1.9e-27 94.9 0.0 3.7e-27 94.0 0.0 1.5 1 0 0 1 1 1 1 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 001345936.1_40422001_3 - 8.6e-05 22.2 0.1 0.00014 21.6 0.1 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.4 001345936.1_40422001_3 - 0.00034 20.2 0.0 0.00055 19.6 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase Toxin-deaminase PF14424.4 001345936.1_40422001_3 - 0.03 14.3 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 The BURPS668_1122 family of deaminases DUF4790 PF16037.3 001345936.1_40422001_3 - 0.043 14.1 0.4 7.4 7.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4790) XOO_2897-deam PF14440.4 001345936.1_40422001_3 - 0.1 12.6 0.1 0.7 9.9 0.1 2.0 2 0 0 2 2 2 0 Xanthomonas XOO_2897-like deaminase IML1 PF12257.6 001169037.1_40429001_1 - 7.5e-87 290.9 1.3 5.6e-49 166.6 0.0 2.3 1 1 1 2 2 2 2 Vacuolar membrane-associated protein Iml1 DEP PF00610.19 001169037.1_40429001_1 - 1.4e-10 41.0 0.1 3.4e-10 39.7 0.1 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FGGY_N PF00370.19 001169037.1_40429001_1 - 0.021 14.3 0.0 0.035 13.5 0.0 1.3 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain Serpin PF00079.18 001168914.1_40423001_1 - 1.8e-136 455.2 13.0 2e-136 455.0 13.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Rdx PF10262.7 001159414.1_29627001_3 - 8.8e-10 38.5 0.0 2.2e-09 37.3 0.0 1.7 1 0 0 1 1 1 1 Rdx family MHC_I PF00129.16 001279520.1_40423001_1 - 1.9e-92 307.6 2.0 3e-92 307.0 2.0 1.3 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001279520.1_40423001_1 - 6.3e-18 64.9 0.1 1.5e-17 63.7 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001279520.1_40423001_1 - 3.7e-16 58.6 9.6 6.7e-16 57.8 9.6 1.4 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 001279520.1_40423001_1 - 5.7e-06 26.7 1.0 0.016 15.7 0.1 2.9 1 1 1 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001279520.1_40423001_1 - 0.0002 21.2 0.1 0.00052 19.9 0.1 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001279520.1_40423001_1 - 0.0014 18.6 0.1 0.0045 17.0 0.1 1.8 1 0 0 1 1 1 1 Immunoglobulin domain DUF1049 PF06305.9 001279520.1_40423001_1 - 0.081 12.6 0.2 0.18 11.5 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Podoplanin PF05808.9 001279520.1_40423001_1 - 0.14 12.1 0.1 0.31 11.0 0.1 1.5 1 0 0 1 1 1 0 Podoplanin Troponin PF00992.18 001257353.2_49823001_1 - 1.5e-35 122.3 51.1 2.3e-31 108.7 37.4 3.1 2 1 1 3 3 3 2 Troponin Troponin PF00992.18 001353845.1_49823001_1 - 1.6e-35 122.2 51.1 2.4e-31 108.7 37.4 3.1 2 1 1 3 3 3 2 Troponin DUF4816 PF16086.3 001353845.1_49823001_2 - 2.3 8.1 5.2 5.6 6.9 5.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4816) Troponin PF00992.18 001353846.1_49823001_1 - 1.4e-35 122.4 50.9 2.2e-31 108.8 37.4 3.1 2 1 1 3 3 3 2 Troponin TFIIS_C PF01096.16 001168812.1_40421001_1 - 7.1e-21 73.7 6.7 7.1e-21 73.7 6.7 2.8 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.14 001168812.1_40421001_1 - 1.6e-08 34.2 1.3 1.6e-08 34.2 1.3 2.3 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit Lar_restr_allev PF14354.4 001168812.1_40421001_1 - 0.019 15.2 10.9 0.46 10.8 1.1 2.2 2 0 0 2 2 2 0 Restriction alleviation protein Lar Nudix_N_2 PF14803.4 001168812.1_40421001_1 - 0.02 14.6 5.6 0.02 14.6 5.6 3.1 3 0 0 3 3 3 0 Nudix N-terminal zf-SAP30 PF13866.4 001168812.1_40421001_1 - 0.021 14.8 0.1 0.061 13.2 0.1 1.7 2 0 0 2 2 2 0 SAP30 zinc-finger Baculo_LEF5_C PF11792.6 001168812.1_40421001_1 - 0.047 13.2 1.3 0.12 11.9 1.3 1.9 1 1 0 1 1 1 0 Baculoviridae late expression factor 5 C-terminal domain Zn_Tnp_IS1595 PF12760.5 001168812.1_40421001_1 - 1.4 8.8 15.9 0.79 9.6 5.1 2.6 2 1 0 2 2 2 0 Transposase zinc-ribbon domain zf-ribbon_3 PF13248.4 001168812.1_40421001_1 - 2.1 7.8 13.5 1.1 8.7 0.1 3.6 4 0 0 4 4 4 0 zinc-ribbon domain Zn_ribbon_recom PF13408.4 001168812.1_40421001_1 - 6.3 7.3 11.0 0.15 12.5 0.9 2.3 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf-H2C2_2 PF13465.4 001168811.1_40422001_1 - 6.3e-48 159.0 68.7 3.2e-09 36.7 1.9 9.4 9 1 0 9 9 9 9 Zinc-finger double domain zf-C2H2 PF00096.24 001168811.1_40422001_1 - 2e-25 87.7 76.5 2.7e-05 24.2 3.3 9.3 9 0 0 9 9 9 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001168811.1_40422001_1 - 8.2e-21 72.8 71.5 0.002 18.7 3.0 9.2 9 0 0 9 9 9 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001168811.1_40422001_1 - 3.9e-16 58.4 55.8 0.00019 21.1 2.7 9.4 9 0 0 9 9 9 8 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001168811.1_40422001_1 - 5.2e-08 32.7 49.9 0.025 14.6 5.3 8.0 4 2 5 9 9 9 7 Zinc ribbon domain zinc_ribbon_15 PF17032.3 001168811.1_40422001_1 - 0.054 14.1 37.0 0.46 11.1 2.1 5.0 1 1 4 5 5 5 0 zinc-ribbon family BolA PF01722.16 001168811.1_40422001_1 - 0.16 12.2 3.3 0.97 9.6 0.1 3.1 2 2 1 3 3 3 0 BolA-like protein FYVE PF01363.19 001168811.1_40422001_1 - 0.24 11.4 49.5 1.5 8.9 6.5 6.0 1 1 3 4 4 4 0 FYVE zinc finger Desulfoferrod_N PF06397.10 001168811.1_40422001_1 - 0.3 10.6 32.1 0.56 9.7 0.0 7.5 8 0 0 8 8 8 0 Desulfoferrodoxin, N-terminal domain DUF3268 PF11672.6 001168811.1_40422001_1 - 0.64 10.2 31.5 0.12 12.5 2.8 5.1 2 1 2 5 5 5 0 zinc-finger-containing domain zf-C2H2_jaz PF12171.6 001168811.1_40422001_1 - 0.76 10.0 0.1 0.76 10.0 0.1 8.5 10 0 0 10 10 8 0 Zinc-finger double-stranded RNA-binding zf-trcl PF13451.4 001168811.1_40422001_1 - 0.83 9.5 41.1 1.6 8.5 0.1 8.6 8 1 0 8 8 8 0 Probable zinc-ribbon domain zf-C2H2_11 PF16622.3 001168811.1_40422001_1 - 1.5 8.5 52.6 1.5 8.5 0.1 8.9 9 0 0 9 9 9 0 zinc-finger C2H2-type zinc-ribbons_6 PF07191.10 001168811.1_40422001_1 - 2.7 7.9 43.5 28 4.7 5.7 7.1 1 1 1 2 2 1 0 zinc-ribbons FerB PF08150.10 001168811.1_40422001_1 - 8.4 7.0 9.8 6.1 7.4 0.2 4.3 1 1 4 6 6 6 0 FerB (NUC096) domain ATP-gua_Ptrans PF00217.17 001169031.1_40423001_1 - 9.8e-96 319.9 0.0 1.2e-95 319.7 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.13 001169031.1_40423001_1 - 2e-31 108.1 0.0 3.2e-31 107.4 0.0 1.3 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain NPR3 PF03666.11 001169049.1_40424001_1 - 1.5e-48 165.7 3.8 3.4e-39 134.8 2.6 2.6 1 1 1 2 2 2 2 Nitrogen Permease regulator of amino acid transport activity 3 NPR2 PF06218.9 001169049.1_40424001_1 - 0.0018 17.0 0.0 0.83 8.3 0.0 2.3 2 0 0 2 2 2 2 Nitrogen permease regulator 2 Glyco_hydro_31 PF01055.24 001194089.2_29626001_3 - 8.3e-55 186.6 0.0 3.1e-53 181.4 0.0 2.2 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 Melibiase PF02065.16 001194089.2_29626001_3 - 0.16 10.8 0.0 0.24 10.2 0.0 1.1 1 0 0 1 1 1 0 Melibiase CARD_2 PF16739.3 001100194.1_49827001_1 - 6.9e-45 150.8 0.1 3.5e-21 74.9 0.0 2.7 2 0 0 2 2 2 2 Caspase recruitment domain RIG-I_C-RD PF11648.6 001100194.1_49827001_1 - 1.5e-38 131.5 2.3 1.5e-38 131.5 2.3 2.2 2 0 0 2 2 2 1 C-terminal domain of RIG-I Helicase_C PF00271.29 001100194.1_49827001_1 - 1.5e-21 76.7 1.3 7.4e-20 71.3 0.3 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 001100194.1_49827001_1 - 4.3e-20 72.3 0.0 4.3e-20 72.3 0.0 2.5 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.27 001100194.1_49827001_1 - 1.3e-18 67.3 0.0 4e-18 65.7 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase CARD PF00619.19 001100194.1_49827001_1 - 8.4e-14 51.2 0.2 4.6e-11 42.5 0.5 2.8 2 0 0 2 2 2 1 Caspase recruitment domain AAA_22 PF13401.4 001100194.1_49827001_1 - 0.012 15.8 1.0 0.3 11.2 0.1 3.5 3 1 0 3 3 2 0 AAA domain DUF3638 PF12340.6 001100194.1_49827001_1 - 0.035 13.3 0.0 0.084 12.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3638) AAA_19 PF13245.4 001100194.1_49827001_1 - 0.04 14.1 1.1 0.4 10.9 0.1 3.1 3 1 0 3 3 3 0 AAA domain AAA_11 PF13086.4 001100194.1_49827001_1 - 0.73 9.4 14.4 0.59 9.7 0.1 3.9 3 1 1 4 4 4 0 AAA domain Sigma70_ner PF04546.11 001100194.1_49827001_1 - 1.7 8.4 13.0 0.53 10.0 8.1 2.6 3 0 0 3 3 3 0 Sigma-70, non-essential region zf-B_box PF00643.22 001100194.1_49827001_1 - 2.3 8.3 5.7 0.73 9.9 0.6 2.6 3 0 0 3 3 3 0 B-box zinc finger APOBEC_N PF08210.9 001123036.1_22422001_1 - 3e-44 150.9 3.4 3.3e-44 150.8 3.4 1.0 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001123036.1_22422001_1 - 1.2e-29 102.0 0.3 2.3e-29 101.0 0.3 1.5 1 0 0 1 1 1 1 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 001123036.1_22422001_1 - 0.028 14.2 0.0 0.04 13.7 0.0 1.2 1 0 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region Glyco_hydro_79n PF03662.12 001146130.2_49827001_3 - 1.6e-27 96.2 0.1 5.8e-27 94.4 0.1 1.7 1 1 1 2 2 2 1 Glycosyl hydrolase family 79, N-terminal domain OAS1_C PF10421.7 001031790.1_49823001_1 - 5.4e-75 250.8 0.3 7.9e-75 250.3 0.3 1.2 1 0 0 1 1 1 1 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus Acyl-CoA_dh_N PF02771.14 001031790.1_49823001_3 - 0.089 13.3 0.0 0.17 12.4 0.0 1.4 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, N-terminal domain Trypsin PF00089.24 001168976.1_40423001_1 - 5.9e-70 235.4 0.0 8e-70 235.0 0.0 1.2 1 0 0 1 1 1 1 Trypsin Gla PF00594.18 001168976.1_40423001_1 - 8.9e-22 76.9 10.0 8.9e-22 76.9 10.0 2.1 2 0 0 2 2 2 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FXa_inhibition PF14670.4 001168976.1_40423001_1 - 5.7e-09 36.0 9.8 5.7e-09 36.0 9.8 2.9 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site EGF PF00008.25 001168976.1_40423001_1 - 4e-07 30.1 8.6 4e-07 30.1 8.6 3.4 3 0 0 3 3 3 2 EGF-like domain cEGF PF12662.5 001168976.1_40423001_1 - 1.2e-05 25.0 13.7 0.00036 20.3 0.2 3.3 3 0 0 3 3 3 2 Complement Clr-like EGF-like hEGF PF12661.5 001168976.1_40423001_1 - 8.2e-05 23.0 4.1 8.2e-05 23.0 4.1 4.0 4 1 0 4 4 3 2 Human growth factor-like EGF Trypsin_2 PF13365.4 001168976.1_40423001_1 - 0.00095 19.9 0.0 0.0019 19.0 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001168976.1_40423001_1 - 0.008 16.4 0.0 0.016 15.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) EGF_2 PF07974.11 001168976.1_40423001_1 - 0.025 14.8 11.6 0.025 14.8 11.6 3.4 3 0 0 3 3 3 0 EGF-like domain EGF_3 PF12947.5 001168976.1_40423001_1 - 0.06 13.4 27.3 0.53 10.4 9.1 2.8 2 0 0 2 2 2 0 EGF domain DUF3510 PF12022.6 001168976.1_40423001_1 - 0.5 10.6 2.4 1.9 8.7 0.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF3510) Plasmod_Pvs28 PF06247.9 001168976.1_40423001_1 - 0.73 10.1 18.0 0.13 12.5 5.2 2.8 1 1 1 2 2 2 0 Pvs28 EGF domain EGF_CA PF07645.13 001168976.1_40423001_1 - 4.2 7.5 29.7 0.17 12.0 10.4 3.1 2 1 1 3 3 3 0 Calcium-binding EGF domain Trypsin PF00089.24 001168977.1_40423001_1 - 8.7e-24 84.4 0.0 1.5e-23 83.6 0.0 1.4 1 0 0 1 1 1 1 Trypsin Gla PF00594.18 001168977.1_40423001_1 - 8.7e-18 64.1 13.8 1.6e-17 63.3 13.8 1.5 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FXa_inhibition PF14670.4 001168977.1_40423001_1 - 1.7e-11 44.0 22.9 1.9e-10 40.7 8.3 2.8 1 1 1 2 2 2 2 Coagulation Factor Xa inhibitory site cEGF PF12662.5 001168977.1_40423001_1 - 7.8e-07 28.8 18.3 3e-05 23.7 1.8 3.4 3 0 0 3 3 3 2 Complement Clr-like EGF-like EGF PF00008.25 001168977.1_40423001_1 - 1.3e-06 28.5 31.5 0.00028 21.0 8.0 3.0 3 0 0 3 3 3 2 EGF-like domain EGF_CA PF07645.13 001168977.1_40423001_1 - 0.00038 20.5 23.4 0.3 11.2 10.5 2.7 1 1 1 2 2 2 2 Calcium-binding EGF domain EGF_3 PF12947.5 001168977.1_40423001_1 - 0.046 13.8 1.5 0.046 13.8 1.5 3.1 2 1 0 2 2 2 0 EGF domain hEGF PF12661.5 001168977.1_40423001_1 - 0.51 11.0 29.2 0.057 14.0 7.4 3.3 3 0 0 3 3 3 0 Human growth factor-like EGF PCI PF01399.25 001168978.1_40423001_1 - 1.4e-18 67.1 1.9 4.3e-18 65.6 1.9 1.8 1 0 0 1 1 1 1 PCI domain UPF0489 PF12640.5 001168978.1_40423001_1 - 0.075 13.1 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 UPF0489 domain Laminin_G_2 PF02210.22 001168997.1_40429001_1 - 1e-139 459.0 6.7 1.5e-29 103.0 0.1 6.2 6 0 0 6 6 6 6 Laminin G domain Laminin_G_1 PF00054.21 001168997.1_40429001_1 - 9.4e-86 284.5 0.1 4.9e-21 75.2 0.0 7.3 6 1 0 6 6 6 6 Laminin G domain Laminin_G_3 PF13385.4 001168997.1_40429001_1 - 1.9e-19 70.2 1.1 0.00038 20.5 0.0 6.3 6 0 0 6 6 6 5 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.25 001168997.1_40429001_1 - 9.5e-07 28.9 32.0 0.0017 18.5 4.1 3.6 3 0 0 3 3 3 3 EGF-like domain Syndecan PF01034.18 001168997.1_40429001_1 - 1.1e-06 28.3 0.0 2.1e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Syndecan domain hEGF PF12661.5 001168997.1_40429001_1 - 0.049 14.2 27.6 0.13 12.9 5.1 4.2 3 0 0 3 3 3 0 Human growth factor-like EGF DUF202 PF02656.13 001168997.1_40429001_1 - 0.071 13.4 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Glyco_tranf_2_3 PF13641.4 001112611.1_40425001_3 - 6.4e-22 78.4 0.9 1.2e-19 71.1 0.1 2.2 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Chitin_synth_2 PF03142.13 001112611.1_40425001_3 - 1.9e-17 63.0 0.1 7.9e-14 51.0 0.1 3.0 2 1 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.4 001112611.1_40425001_3 - 3.7e-13 49.7 8.7 3.7e-13 49.7 8.7 2.8 2 1 1 3 3 3 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.24 001112611.1_40425001_3 - 2.4e-09 37.1 0.0 0.00015 21.5 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_transf_21 PF13506.4 001112611.1_40425001_3 - 3e-06 26.7 0.0 6.7e-06 25.6 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 21 B56 PF01603.18 001169004.1_40423001_1 - 6.3e-187 621.5 2.3 7.8e-187 621.2 2.3 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) FTCD_C PF04961.10 001169004.1_40423001_1 - 0.046 13.3 0.1 0.077 12.6 0.1 1.2 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase Pox_D5 PF03288.14 001169004.1_40423001_1 - 0.15 12.5 0.2 6.9 7.1 0.1 2.5 2 0 0 2 2 2 0 Poxvirus D5 protein-like Sec63 PF02889.14 001169014.1_40425001_1 - 1.3e-19 70.2 5.6 2.9e-09 36.3 0.1 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DnaJ PF00226.29 001169014.1_40425001_1 - 3.9e-17 62.0 0.0 8.8e-17 60.9 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain HAUS6_N PF14661.4 001169014.1_40425001_1 - 0.04 13.4 2.4 0.13 11.7 0.9 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Peptidase_M18 PF02127.13 001169016.1_40423001_1 - 1.2e-191 637.1 0.0 1.4e-191 636.9 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.12 001169016.1_40423001_1 - 5.7e-06 25.4 0.0 4e-05 22.6 0.0 2.1 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase His_Phos_2 PF00328.20 001169075.1_40429001_1 - 7.6e-136 453.3 2.2 3.4e-135 451.2 0.0 2.1 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 2) RimK PF08443.9 001169075.1_40429001_1 - 0.036 13.5 0.0 0.067 12.6 0.0 1.3 1 0 0 1 1 1 0 RimK-like ATP-grasp domain Bud13 PF09736.7 001168766.1_40424001_1 - 3.9e-50 169.9 11.4 3.9e-50 169.9 11.4 2.5 2 1 1 3 3 3 1 Pre-mRNA-splicing factor of RES complex CHGN PF05679.14 001169018.1_40424001_1 - 3e-146 488.2 0.0 3.4e-146 488.0 0.0 1.0 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Fringe PF02434.14 001169018.1_40424001_1 - 0.00046 19.6 0.0 0.00096 18.5 0.0 1.4 1 1 0 1 1 1 1 Fringe-like VWA PF00092.26 001169027.1_40425001_1 - 1.3e-95 318.5 0.0 2.3e-49 167.9 0.0 2.1 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.4 001169027.1_40425001_1 - 1.8e-34 118.5 0.0 7.2e-16 58.7 0.0 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain FXa_inhibition PF14670.4 001169027.1_40425001_1 - 3.4e-22 78.3 43.9 1.8e-09 37.6 7.7 3.6 3 0 0 3 3 3 3 Coagulation Factor Xa inhibitory site cEGF PF12662.5 001169027.1_40425001_1 - 7.1e-13 48.1 16.9 4.8e-05 23.1 0.5 3.8 3 0 0 3 3 3 3 Complement Clr-like EGF-like Matrilin_ccoil PF10393.7 001169027.1_40425001_1 - 9.8e-12 44.4 0.4 1.8e-11 43.5 0.4 1.4 1 0 0 1 1 1 1 Trimeric coiled-coil oligomerisation domain of matrilin EGF_CA PF07645.13 001169027.1_40425001_1 - 2.5e-10 40.2 33.0 1.2e-06 28.5 5.0 3.5 3 0 0 3 3 3 3 Calcium-binding EGF domain EGF PF00008.25 001169027.1_40425001_1 - 1.4e-06 28.3 41.0 0.00052 20.1 6.8 4.0 4 0 0 4 4 4 3 EGF-like domain VWA_3 PF13768.4 001169027.1_40425001_1 - 1.7e-06 27.9 0.1 0.0015 18.3 0.0 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain DUF1194 PF06707.9 001169027.1_40425001_1 - 0.0059 15.7 0.0 0.48 9.5 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1194) hEGF PF12661.5 001169027.1_40425001_1 - 0.2 12.3 30.8 0.19 12.3 5.4 4.7 4 0 0 4 4 4 0 Human growth factor-like EGF Tissue_fac PF01108.15 001169040.1_40424001_1 - 6e-24 83.8 0.2 1.1e-23 82.9 0.2 1.5 1 0 0 1 1 1 1 Tissue factor Interfer-bind PF09294.8 001169040.1_40424001_1 - 6.9e-17 61.5 0.1 1.4e-16 60.5 0.1 1.5 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III G6PD_C PF02781.14 001169047.1_40424001_1 - 5.9e-118 393.2 0.0 1.7e-117 391.6 0.0 1.6 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.20 001169047.1_40424001_1 - 3.4e-60 203.6 0.0 8.7e-60 202.2 0.0 1.7 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, NAD binding domain LUC7 PF03194.13 001169050.1_40423001_1 - 2.6e-82 276.0 17.4 5.8e-82 274.9 17.4 1.6 1 0 0 1 1 1 1 LUC7 N_terminus TSC22 PF01166.16 001169050.1_40423001_1 - 0.59 10.3 5.2 8.1 6.7 0.2 3.0 2 1 0 2 2 2 0 TSC-22/dip/bun family RGS PF00615.17 001169051.1_40423001_1 - 4.2e-32 110.8 0.0 7.1e-32 110.0 0.0 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain DEP PF00610.19 001169051.1_40423001_1 - 7.1e-16 57.9 0.0 1.2e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) G-gamma PF00631.20 001169051.1_40423001_1 - 1.6e-08 34.3 0.0 6.4e-08 32.4 0.0 1.9 2 0 0 2 2 2 1 GGL domain DIX PF00778.15 001169052.1_40426001_1 - 2.7e-30 103.9 0.4 4.5e-30 103.2 0.4 1.4 1 0 0 1 1 1 1 DIX domain RGS PF00615.17 001169052.1_40426001_1 - 3.3e-27 95.0 0.1 6.5e-27 94.0 0.1 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain AXIN1_TNKS_BD PF16646.3 001169052.1_40426001_1 - 3.2e-24 85.4 3.3 3.2e-24 85.4 3.3 2.8 2 0 0 2 2 2 1 Axin-1 tankyrase binding domain Axin_b-cat_bind PF08833.8 001169052.1_40426001_1 - 4.4e-10 39.4 0.2 2.3e-09 37.1 0.2 2.3 1 0 0 1 1 1 1 Axin beta-catenin binding domain NACHT PF05729.10 001169056.1_40427001_1 - 1.8e-55 187.2 0.1 1e-53 181.5 0.0 2.5 2 0 0 2 2 2 1 NACHT domain LRR_6 PF13516.4 001169056.1_40427001_1 - 2.9e-24 82.9 29.5 3.4e-05 23.4 0.4 8.4 8 0 0 8 8 8 6 Leucine Rich repeat PYRIN PF02758.14 001169056.1_40427001_1 - 1.9e-23 82.3 1.0 8.3e-23 80.3 0.3 2.4 2 0 0 2 2 2 1 PAAD/DAPIN/Pyrin domain FISNA PF14484.4 001169056.1_40427001_1 - 8.6e-13 48.2 0.4 2.2e-12 46.9 0.0 1.9 2 0 0 2 2 2 1 Fish-specific NACHT associated domain LRR_4 PF12799.5 001169056.1_40427001_1 - 6.6e-05 23.0 24.3 0.33 11.3 0.2 7.1 5 2 2 7 7 7 3 Leucine Rich repeats (2 copies) NB-ARC PF00931.20 001169056.1_40427001_1 - 0.046 12.6 0.0 0.096 11.6 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_16 PF13191.4 001169056.1_40427001_1 - 0.05 13.8 0.0 1.7 8.9 0.0 2.8 3 0 0 3 3 3 0 AAA ATPase domain LRR_8 PF13855.4 001169056.1_40427001_1 - 0.14 11.8 15.9 14 5.4 0.1 6.3 6 0 0 6 6 6 0 Leucine rich repeat GIT_CC PF16559.3 001168872.1_40422001_1 - 0.041 13.8 0.4 0.081 12.8 0.4 1.4 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor MAD PF05557.11 001168872.1_40422001_1 - 0.23 9.6 6.1 0.3 9.2 6.1 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein FAM176 PF14851.4 001168777.1_40423001_1 - 2.1e-54 183.0 0.0 3e-54 182.5 0.0 1.2 1 0 0 1 1 1 1 FAM176 family Gal_Lectin PF02140.16 001168777.1_40423001_1 - 2.6e-40 136.6 11.5 5e-20 71.6 1.9 2.3 2 0 0 2 2 2 2 Galactose binding lectin domain RFX5_DNA_bdg PF14621.4 001169073.1_40424001_1 - 1.4e-118 394.3 20.2 1.4e-118 394.3 20.2 1.7 2 0 0 2 2 2 1 RFX5 DNA-binding domain RFX_DNA_binding PF02257.13 001169073.1_40424001_1 - 6e-29 100.4 0.9 9e-29 99.8 0.9 1.3 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.14 001169073.1_40424001_1 - 0.00092 19.6 0.0 0.0019 18.5 0.0 1.4 1 0 0 1 1 1 1 Poxvirus D5 protein-like ig PF00047.23 001168890.1_40423001_1 - 9.5e-26 89.7 0.0 3.7e-11 42.9 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 001168890.1_40423001_1 - 1.3e-14 54.1 0.0 9.1e-07 29.0 0.0 3.5 3 1 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.4 001168890.1_40423001_1 - 1.7e-12 47.6 0.0 0.012 16.1 0.0 4.0 4 0 0 4 4 4 3 Immunoglobulin domain V-set PF07686.15 001168890.1_40423001_1 - 0.00025 21.0 0.0 14 5.7 0.0 4.5 5 0 0 5 5 5 2 Immunoglobulin V-set domain DUF2933 PF11666.6 001168890.1_40423001_1 - 0.07 13.0 0.3 0.27 11.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2933) Chlorophyllase2 PF12740.5 001168890.1_40423001_1 - 0.16 10.7 0.0 0.23 10.2 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Interfer-bind PF09294.8 001168782.1_40422001_1 - 4.1e-31 107.2 0.1 1.2e-30 105.7 0.1 1.8 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III Tissue_fac PF01108.15 001168782.1_40422001_1 - 1.2e-14 53.9 6.9 2.1e-14 53.1 0.0 2.9 2 1 0 2 2 2 1 Tissue factor fn3 PF00041.19 001168782.1_40422001_1 - 0.0067 16.6 3.0 0.038 14.2 0.8 2.9 2 2 0 2 2 2 1 Fibronectin type III domain DUF3844 PF12955.5 001168782.1_40422001_1 - 0.093 12.7 0.3 0.18 11.8 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3844) Homeobox PF00046.27 001168898.1_40422001_1 - 1.4e-21 75.9 8.1 2e-21 75.4 8.1 1.2 1 0 0 1 1 1 1 Homeobox domain Ribosomal_60s PF00428.17 001168898.1_40422001_1 - 0.02 15.3 11.6 0.039 14.4 11.6 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF2209 PF09974.7 001168898.1_40422001_1 - 0.21 11.8 0.1 0.28 11.4 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) Tissue_fac PF01108.15 001168784.1_40423001_1 - 3.1e-17 62.2 0.0 5.9e-17 61.3 0.0 1.4 1 0 0 1 1 1 1 Tissue factor fn3 PF00041.19 001168784.1_40423001_1 - 4.3e-08 33.3 0.1 2.3e-05 24.5 0.0 2.3 2 0 0 2 2 2 2 Fibronectin type III domain Interfer-bind PF09294.8 001168784.1_40423001_1 - 5.6e-08 32.9 0.0 9.5e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III MMR_HSR1 PF01926.21 001169083.1_40423001_1 - 1.5e-22 79.7 0.0 2.5e-22 79.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP1_OBG PF01018.20 001169083.1_40423001_1 - 2.8e-18 65.8 6.3 1.2e-17 63.8 6.3 1.9 1 1 0 1 1 1 1 GTP1/OBG FeoB_N PF02421.16 001169083.1_40423001_1 - 1.9e-09 37.1 0.0 9.1e-08 31.6 0.0 2.7 3 0 0 3 3 3 1 Ferrous iron transport protein B ArgK PF03308.14 001169083.1_40423001_1 - 6.7e-06 25.1 0.0 0.0013 17.6 0.0 2.2 2 0 0 2 2 2 2 ArgK protein Arf PF00025.19 001169083.1_40423001_1 - 0.00011 21.6 0.0 0.00026 20.4 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001169083.1_40423001_1 - 0.00018 21.0 0.0 0.0027 17.1 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 001169083.1_40423001_1 - 0.0093 15.2 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MnmE_helical PF12631.5 001169083.1_40423001_1 - 0.069 13.2 0.0 0.083 12.9 0.0 1.3 1 1 0 1 1 1 0 MnmE helical domain Tox-REase-7 PF15649.4 001169083.1_40423001_1 - 0.076 13.2 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 7 PduV-EutP PF10662.7 001169083.1_40423001_1 - 0.081 12.5 0.0 0.24 11.0 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation PX PF00787.22 001168902.1_40423001_1 - 6.5e-21 74.3 0.3 9.8e-20 70.5 0.3 2.4 2 0 0 2 2 2 1 PX domain Vps5 PF09325.8 001168902.1_40423001_1 - 8.4e-15 54.8 17.0 1e-13 51.3 11.7 2.5 2 1 0 2 2 2 1 Vps5 C terminal like BAR PF03114.16 001168902.1_40423001_1 - 4.7e-07 29.5 17.4 1.6e-05 24.6 9.5 2.7 3 0 0 3 3 3 2 BAR domain Asp PF00026.21 001168903.1_40423001_1 - 1.6e-119 398.8 0.0 3.3e-119 397.8 0.0 1.4 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001168903.1_40423001_1 - 2.7e-13 50.4 0.7 6.1e-11 42.8 0.7 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001168903.1_40423001_1 - 1.2e-09 37.7 0.0 2.1e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 A1 Propeptide TAXi_C PF14541.4 001168903.1_40423001_1 - 9.1e-07 28.6 0.0 2.1e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Bromodomain PF00439.23 001169085.1_40429001_1 - 2.9e-37 126.5 0.1 1.6e-17 63.2 0.1 2.5 2 0 0 2 2 2 2 Bromodomain WD40 PF00400.30 001169085.1_40429001_1 - 1.3e-35 120.6 13.3 1.9e-05 25.2 0.5 9.0 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001169085.1_40429001_1 - 9e-08 32.2 0.4 0.019 15.1 0.1 5.0 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain RhoGAP PF00620.25 001168792.1_40426001_1 - 2.9e-44 150.4 0.0 1e-43 148.7 0.0 1.9 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.21 001168792.1_40426001_1 - 4.1e-13 49.3 0.8 4.1e-13 49.3 0.8 2.6 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.26 001168792.1_40426001_1 - 3e-12 45.8 0.0 8.6e-12 44.3 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 001168792.1_40426001_1 - 6.6e-12 45.0 0.0 1.6e-11 43.7 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001168792.1_40426001_1 - 1.6e-10 40.4 0.0 3.8e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain DEAD PF00270.27 001168910.1_40425001_1 - 3.1e-45 153.9 0.1 6.8e-45 152.8 0.1 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001168910.1_40425001_1 - 1.4e-23 83.2 0.0 2e-22 79.5 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.4 001168910.1_40425001_1 - 2.7e-19 69.0 0.3 5e-19 68.1 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.13 001168910.1_40425001_1 - 1.5e-06 28.2 0.0 1.5e-06 28.2 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit NPR3 PF03666.11 001168910.1_40425001_1 - 2.2 6.8 7.4 3.8 6.1 7.4 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 GlcNAc_2-epim PF07221.9 001168794.1_40423001_1 - 1.1e-42 146.4 0.0 1.5e-42 146.0 0.0 1.1 1 0 0 1 1 1 1 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) PLN_propep PF16485.3 001168794.1_40423001_1 - 0.17 11.6 0.2 14 5.4 0.0 2.4 2 0 0 2 2 2 0 Protealysin propeptide Pkinase PF00069.23 001168919.1_40429001_1 - 2.4e-40 138.4 0.0 6.2e-40 137.1 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001168919.1_40429001_1 - 3.4e-39 134.6 0.0 6.9e-39 133.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Roc PF08477.11 001168919.1_40429001_1 - 5.3e-31 107.2 0.2 2.5e-30 105.0 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase LRR_8 PF13855.4 001168919.1_40429001_1 - 1.2e-28 98.5 30.2 1.5e-07 31.0 1.9 7.6 4 2 0 7 7 7 5 Leucine rich repeat COR PF16095.3 001168919.1_40429001_1 - 2.8e-27 95.6 3.0 6e-25 88.1 0.2 3.1 3 0 0 3 3 3 1 C-terminal of Roc, COR, domain LRR_4 PF12799.5 001168919.1_40429001_1 - 2e-26 91.4 41.8 1e-06 28.8 0.3 9.0 5 1 3 9 9 8 7 Leucine Rich repeats (2 copies) Ras PF00071.20 001168919.1_40429001_1 - 1.6e-16 60.2 0.0 4.2e-16 58.8 0.0 1.7 1 0 0 1 1 1 1 Ras family LRR_9 PF14580.4 001168919.1_40429001_1 - 1.2e-06 28.0 6.9 0.016 14.6 0.5 4.1 2 1 1 4 4 3 3 Leucine-rich repeat Arf PF00025.19 001168919.1_40429001_1 - 5.8e-05 22.5 1.0 0.00018 20.9 0.1 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family Ank_2 PF12796.5 001168919.1_40429001_1 - 0.00023 21.6 0.1 0.0013 19.1 0.1 2.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) T2SSE PF00437.18 001168919.1_40429001_1 - 0.0035 16.3 0.0 0.008 15.1 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein LRR_6 PF13516.4 001168919.1_40429001_1 - 0.0037 17.1 37.4 0.3 11.1 0.1 11.8 13 0 0 13 13 11 1 Leucine Rich repeat AAA_22 PF13401.4 001168919.1_40429001_1 - 0.0095 16.1 0.0 0.038 14.1 0.0 2.1 1 0 0 1 1 1 1 AAA domain Kdo PF06293.12 001168919.1_40429001_1 - 0.0096 15.2 0.1 0.045 13.0 0.1 2.0 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family ABC_tran PF00005.25 001168919.1_40429001_1 - 0.011 16.1 0.0 0.044 14.2 0.0 2.0 1 0 0 1 1 1 0 ABC transporter PduV-EutP PF10662.7 001168919.1_40429001_1 - 0.013 15.2 0.2 0.05 13.2 0.2 2.1 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.10 001168919.1_40429001_1 - 0.014 15.2 0.5 0.061 13.1 0.5 2.1 1 0 0 1 1 1 0 NACHT domain NB-ARC PF00931.20 001168919.1_40429001_1 - 0.016 14.1 0.2 0.046 12.6 0.2 1.8 1 0 0 1 1 1 0 NB-ARC domain G-alpha PF00503.18 001168919.1_40429001_1 - 0.018 14.1 3.1 0.066 12.2 0.2 2.7 2 0 0 2 2 2 0 G-protein alpha subunit AAA_16 PF13191.4 001168919.1_40429001_1 - 0.021 15.1 0.0 0.082 13.1 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain Septin PF00735.16 001168919.1_40429001_1 - 0.022 13.9 0.0 0.043 12.9 0.0 1.4 1 0 0 1 1 1 0 Septin Gtr1_RagA PF04670.10 001168919.1_40429001_1 - 0.029 13.6 0.0 0.074 12.3 0.0 1.7 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_33 PF13671.4 001168919.1_40429001_1 - 0.032 14.3 0.1 0.085 12.9 0.1 1.7 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.21 001168919.1_40429001_1 - 0.033 14.2 0.0 0.11 12.5 0.0 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase cobW PF02492.17 001168919.1_40429001_1 - 0.035 13.6 0.1 0.073 12.5 0.1 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain PQQ_2 PF13360.4 001168919.1_40429001_1 - 0.039 13.4 0.0 0.08 12.4 0.0 1.4 1 0 0 1 1 1 0 PQQ-like domain MobB PF03205.12 001168919.1_40429001_1 - 0.043 13.6 0.2 0.1 12.4 0.2 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B TsaE PF02367.15 001168919.1_40429001_1 - 0.044 13.7 0.1 0.16 11.9 0.1 1.9 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE FtsK_SpoIIIE PF01580.16 001168919.1_40429001_1 - 0.048 12.9 0.8 0.096 11.9 0.1 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family ATP-synt_ab PF00006.23 001168919.1_40429001_1 - 0.054 13.0 0.0 4.9 6.6 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain TniB PF05621.9 001168919.1_40429001_1 - 0.079 12.0 0.1 0.26 10.3 0.1 1.9 1 0 0 1 1 1 0 Bacterial TniB protein Arm PF00514.21 001168919.1_40429001_1 - 0.083 12.8 2.2 0.24 11.3 0.2 3.0 3 0 0 3 3 1 0 Armadillo/beta-catenin-like repeat Viral_helicase1 PF01443.16 001168919.1_40429001_1 - 0.097 12.3 0.0 0.25 10.9 0.0 1.7 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase TrwB_AAD_bind PF10412.7 001168919.1_40429001_1 - 0.11 11.3 0.0 0.21 10.3 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain HEAT_EZ PF13513.4 001168919.1_40429001_1 - 0.18 12.2 0.2 5.6 7.4 0.0 3.3 3 0 0 3 3 3 0 HEAT-like repeat DUF1043 PF06295.10 001168919.1_40429001_1 - 0.26 11.2 1.2 27 4.6 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) zf-C2H2_assoc2 PF16624.3 001168925.1_40424001_1 - 6.4e-38 129.5 16.0 6.4e-38 129.5 16.0 4.1 5 1 0 5 5 3 1 Unstructured region upstream of a zinc-finger zf-C2H2_4 PF13894.4 001168925.1_40424001_1 - 1.5e-16 59.5 55.9 0.0031 18.1 2.0 7.7 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2 PF00096.24 001168925.1_40424001_1 - 3e-15 55.6 58.3 0.0021 18.3 1.6 7.8 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_11 PF16622.3 001168925.1_40424001_1 - 3.6e-14 52.1 11.8 4.6e-14 51.7 5.3 6.6 7 0 0 7 7 7 4 zinc-finger C2H2-type zf-C2H2_2 PF12756.5 001168925.1_40424001_1 - 1.6e-05 25.0 34.6 0.029 14.5 1.4 7.1 6 1 1 7 7 7 3 C2H2 type zinc-finger (2 copies) zf-met PF12874.5 001168925.1_40424001_1 - 7.9e-05 22.8 42.2 0.0021 18.3 0.7 7.0 7 0 0 7 7 6 3 Zinc-finger of C2H2 type zf-Di19 PF05605.10 001168925.1_40424001_1 - 8.2e-05 22.7 26.4 0.0013 18.8 1.7 6.0 5 0 0 5 5 5 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.6 001168925.1_40424001_1 - 0.00051 20.2 1.4 0.00051 20.2 1.4 7.4 7 1 0 7 7 5 3 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 001168925.1_40424001_1 - 0.0008 19.0 0.8 0.0008 19.0 0.8 6.3 6 0 0 6 6 5 2 C2H2-type zinc-finger domain zf-C2H2_8 PF15909.3 001168925.1_40424001_1 - 0.00089 19.4 1.2 0.00089 19.4 1.2 4.3 5 1 0 5 5 5 1 C2H2-type zinc ribbon zf-C2H2_9 PF16293.3 001168925.1_40424001_1 - 0.0025 17.5 10.7 7.3 6.4 0.0 5.0 5 0 0 5 5 5 1 C2H2 type zinc-finger (1 copy) zf-H2C2_2 PF13465.4 001168925.1_40424001_1 - 0.0082 16.4 0.5 0.0082 16.4 0.5 10.3 11 1 0 11 11 10 4 Zinc-finger double domain zf-C2H2_6 PF13912.4 001168925.1_40424001_1 - 0.052 13.4 0.7 0.052 13.4 0.7 6.7 7 0 0 7 7 7 0 C2H2-type zinc finger FAM35_C PF15793.3 001168925.1_40424001_1 - 0.093 12.0 1.0 0.45 9.8 0.0 2.6 3 0 0 3 3 3 0 Protein family FAM35, C-terminal Acyltransferase PF01553.19 001168803.1_40422001_1 - 2.5e-42 143.6 0.0 3.4e-42 143.1 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase ILEI PF15711.3 001168807.1_40422001_1 - 4.8e-26 90.9 0.0 7.1e-26 90.4 0.0 1.3 1 0 0 1 1 1 1 Interleukin-like EMT inducer ELM2 PF01448.22 001168932.1_40424001_1 - 7.7e-09 36.1 0.1 2.1e-08 34.6 0.1 1.8 1 0 0 1 1 1 1 ELM2 domain Myb_DNA-binding PF00249.29 001168932.1_40424001_1 - 1.8e-06 27.9 0.0 5.7e-06 26.3 0.1 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.3 001168932.1_40424001_1 - 0.0024 17.6 0.0 0.007 16.1 0.0 1.7 1 0 0 1 1 1 1 Myb DNA-binding like GAT PF03127.12 001168932.1_40424001_1 - 0.024 14.8 0.1 0.092 12.9 0.1 2.0 1 0 0 1 1 1 0 GAT domain NEMO PF11577.6 001168932.1_40424001_1 - 0.1 12.5 0.5 0.21 11.5 0.5 1.6 1 0 0 1 1 1 0 NF-kappa-B essential modulator NEMO PKI PF02827.14 001168932.1_40424001_1 - 0.21 11.7 2.1 0.55 10.3 2.1 1.7 1 0 0 1 1 1 0 cAMP-dependent protein kinase inhibitor Lectin_C PF00059.19 001112626.1_40424001_1 - 2e-24 86.3 2.6 5.2e-24 84.9 2.6 1.8 1 0 0 1 1 1 1 Lectin C-type domain Sushi PF00084.18 001112626.1_40424001_1 - 3.8e-11 43.3 18.3 2.1e-06 28.1 4.0 3.4 2 1 1 3 3 3 2 Sushi repeat (SCR repeat) EGF PF00008.25 001112626.1_40424001_1 - 0.00042 20.4 10.5 0.00042 20.4 10.5 3.2 2 0 0 2 2 2 1 EGF-like domain hEGF PF12661.5 001112626.1_40424001_1 - 0.0026 18.2 6.6 0.021 15.4 6.6 2.8 1 0 0 1 1 1 1 Human growth factor-like EGF EGF_2 PF07974.11 001112626.1_40424001_1 - 0.0042 17.3 11.2 0.025 14.8 11.2 2.5 1 0 0 1 1 1 1 EGF-like domain EGF_3 PF12947.5 001112626.1_40424001_1 - 0.82 9.8 10.1 0.19 11.8 4.5 3.0 2 0 0 2 2 2 0 EGF domain ubiquitin PF00240.21 001168813.1_40421001_1 - 3e-06 26.7 0.4 0.057 13.0 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin family MOEP19 PF16005.3 001168937.1_40422001_1 - 2.4e-36 123.5 0.1 4.5e-36 122.6 0.1 1.4 1 0 0 1 1 1 1 KH-like RNA-binding domain UDPGT PF00201.16 001172142.1_40424001_3 - 1.6e-260 865.0 0.6 1.9e-260 864.7 0.6 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001172142.1_40424001_3 - 1.1e-06 28.6 0.0 2e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.4 001172142.1_40424001_3 - 0.00038 20.4 0.0 0.0074 16.2 0.0 2.4 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_2 PF13477.4 001172142.1_40424001_3 - 0.00064 19.6 0.0 0.91 9.4 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferase 4-like Glyco_trans_4_4 PF13579.4 001172142.1_40424001_3 - 0.0056 17.0 0.0 0.021 15.2 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_3 PF13528.4 001172142.1_40424001_3 - 0.12 11.4 0.0 7.4 5.6 0.0 2.3 2 0 0 2 2 2 0 Glycosyl transferase family 1 Pro_3_hydrox_C PF05373.9 001172142.1_40424001_3 - 0.15 12.0 0.1 0.98 9.4 0.0 2.1 2 0 0 2 2 2 0 L-proline 3-hydroxylase, C-terminal Globin PF00042.20 001168848.1_40421001_1 - 9.4e-15 55.0 0.5 5.5e-14 52.5 0.0 1.9 2 0 0 2 2 2 1 Globin Globin PF00042.20 001168849.1_40421001_1 - 3.2e-31 108.0 0.0 1.3e-30 106.1 0.0 1.7 2 0 0 2 2 2 1 Globin Sugar_tr PF00083.22 001173980.1_40423001_1 - 3.4e-153 510.6 20.1 4.2e-153 510.3 20.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001173980.1_40423001_1 - 1.5e-20 73.4 28.5 1.1e-18 67.1 23.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2127 PF09900.7 001173980.1_40423001_1 - 0.023 14.8 1.2 0.023 14.8 1.2 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2127) DUF523 PF04463.10 001173980.1_40423001_1 - 0.058 13.3 0.1 0.1 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF523) TRI12 PF06609.11 001173980.1_40423001_1 - 0.064 11.5 7.8 0.0094 14.3 3.3 1.7 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) Pox_EPC_I2-L1 PF12575.6 001173980.1_40423001_1 - 1.1 9.4 5.6 0.28 11.3 1.2 2.5 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 IL8 PF00048.18 001173537.1_40421001_1 - 4.8e-17 61.7 0.3 6e-17 61.4 0.3 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like zf-RING_UBOX PF13445.4 001168862.1_40423001_1 - 3.3e-12 46.1 7.7 3.6e-11 42.8 2.4 3.1 3 0 0 3 3 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 001168862.1_40423001_1 - 1.2e-11 44.4 8.2 1.2e-11 44.4 8.2 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001168862.1_40423001_1 - 5.2e-10 38.9 7.2 1.5e-09 37.4 7.2 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001168862.1_40423001_1 - 9.3e-09 35.2 3.9 9.3e-09 35.2 3.9 3.1 3 1 0 3 3 3 1 B-box zinc finger zf-C3HC4_2 PF13923.4 001168862.1_40423001_1 - 1.5e-08 34.2 7.2 2.9e-07 30.1 8.2 2.6 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SPRY PF00622.26 001168862.1_40423001_1 - 1.2e-07 31.8 1.8 1.6e-07 31.3 0.2 1.9 2 0 0 2 2 2 1 SPRY domain zf-RING_2 PF13639.4 001168862.1_40423001_1 - 2.4e-07 30.8 7.0 2.4e-07 30.8 7.0 2.4 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.4 001168862.1_40423001_1 - 2.2e-06 27.4 5.4 2.2e-06 27.4 5.4 3.2 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 001168862.1_40423001_1 - 4.7e-06 26.2 5.2 4.7e-06 26.2 5.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.6 001168862.1_40423001_1 - 0.0019 17.9 4.4 0.0066 16.1 4.4 1.9 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.13 001168862.1_40423001_1 - 0.0026 17.8 0.0 0.0056 16.7 0.0 1.6 1 0 0 1 1 1 1 U-box domain SF-assemblin PF06705.9 001168862.1_40423001_1 - 0.0036 16.6 11.7 0.76 8.9 0.0 2.3 1 1 1 2 2 2 2 SF-assemblin/beta giardin zf-RING_6 PF14835.4 001168862.1_40423001_1 - 0.007 16.1 5.2 0.025 14.3 5.2 2.0 1 1 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.3 001168862.1_40423001_1 - 0.0093 16.0 4.5 0.0093 16.0 4.5 2.6 1 1 1 2 2 2 1 zinc RING finger of MSL2 ABC1 PF03109.14 001168862.1_40423001_1 - 0.092 12.8 0.2 0.25 11.4 0.2 1.7 1 0 0 1 1 1 0 ABC1 family UBZ_FAAP20 PF15750.3 001168862.1_40423001_1 - 0.093 12.5 2.6 0.91 9.4 0.1 2.8 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger Prok-RING_4 PF14447.4 001168862.1_40423001_1 - 0.11 12.2 15.8 0.036 13.8 10.3 2.8 2 1 1 3 3 2 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.4 001168862.1_40423001_1 - 0.22 11.2 5.4 1.6 8.4 5.7 2.3 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Rad50_zn_hook PF04423.12 001168862.1_40423001_1 - 0.39 10.4 0.1 0.39 10.4 0.1 3.7 4 0 0 4 4 4 0 Rad50 zinc hook motif zf-RING_11 PF17123.3 001168862.1_40423001_1 - 1.2 8.8 5.7 10 5.8 3.8 3.0 2 1 0 2 2 2 0 RING-like zinc finger zf-rbx1 PF12678.5 001168862.1_40423001_1 - 1.9 8.7 14.8 0.065 13.4 5.2 2.9 2 1 0 2 2 2 0 RING-H2 zinc finger domain zf-Di19 PF05605.10 001168862.1_40423001_1 - 4.5 7.5 11.5 8.5 6.6 0.1 3.4 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding RRM_3 PF08777.9 001168862.1_40423001_1 - 6.6 6.7 8.0 2.7 8.0 4.5 2.0 1 1 1 2 2 2 0 RNA binding motif IL8 PF00048.18 001198596.1_40421001_1 - 1.4e-24 85.8 0.3 1.6e-24 85.7 0.3 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like ITAM PF02189.13 001112652.1_40422001_1 - 1.4e-21 75.4 5.5 2.7e-06 27.4 0.1 3.4 3 0 0 3 3 3 3 Immunoreceptor tyrosine-based activation motif TCR_zetazeta PF11628.6 001112652.1_40422001_1 - 5.6e-18 64.2 1.5 8.6e-18 63.6 1.5 1.3 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 zeta chain DRMBL PF07522.12 001252422.1_40425001_1 - 5.6e-19 68.4 0.2 1.3e-18 67.2 0.2 1.7 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.5 001252422.1_40425001_1 - 2.8e-07 30.1 0.0 8.4e-07 28.6 0.0 1.7 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.25 001252422.1_40425001_1 - 0.0054 16.6 0.1 0.048 13.5 0.1 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily FA_desaturase PF00487.22 001145086.1_40423001_1 - 3.7e-35 121.8 22.8 3.7e-35 121.8 22.8 2.0 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.26 001145086.1_40423001_1 - 3.4e-19 68.6 0.0 6.4e-19 67.7 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain 53-BP1_Tudor PF09038.8 001168963.1_40429001_1 - 2.3e-77 256.7 0.3 4e-77 255.9 0.3 1.4 1 0 0 1 1 1 1 Tumour suppressor p53-binding protein-1 Tudor BRCT PF00533.24 001168963.1_40429001_1 - 0.00027 21.1 0.0 0.16 12.3 0.0 2.7 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.3 001168963.1_40429001_1 - 0.0058 16.9 0.1 0.073 13.4 0.1 2.5 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.3 001168963.1_40429001_1 - 0.0068 16.1 0.0 0.053 13.3 0.0 2.6 4 0 0 4 4 4 1 Regulator of Ty1 transposition protein 107 BRCT domain DUF4537 PF15057.4 001168963.1_40429001_1 - 0.025 14.4 0.0 0.065 13.1 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) DZR PF12773.5 001168963.1_40429001_2 - 0.092 12.7 2.3 0.66 9.9 0.4 2.7 2 0 0 2 2 2 0 Double zinc ribbon MHC_I PF00129.16 001331057.1_40423001_1 - 1.9e-93 310.9 0.4 2.6e-93 310.4 0.4 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001331057.1_40423001_1 - 6.7e-17 61.6 0.0 1.3e-16 60.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001331057.1_40423001_1 - 5.2e-14 51.7 8.7 9.6e-14 50.9 8.7 1.5 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 001331057.1_40423001_1 - 2.9e-06 27.6 0.8 0.018 15.5 0.0 2.8 1 1 1 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001331057.1_40423001_1 - 0.00038 20.3 0.2 0.00083 19.3 0.2 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001331057.1_40423001_1 - 0.0041 17.1 0.1 0.014 15.4 0.1 1.9 2 0 0 2 2 2 1 Immunoglobulin domain DUF3944 PF13099.4 001168965.1_40426001_1 - 1.6 8.5 6.2 36 4.2 0.1 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3944) CSTF_C PF14304.4 001168965.1_40426001_1 - 5.2 6.6 11.7 3.7 7.1 0.1 4.6 5 0 0 5 5 5 0 Transcription termination and cleavage factor C-terminal PS_Dcarbxylase PF02666.13 001168731.1_40423001_1 - 4.1e-69 232.0 0.0 5e-69 231.7 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase MHC_II_beta PF00969.17 001331059.1_40422001_1 - 2.6e-35 120.2 0.7 4.3e-35 119.5 0.7 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001331059.1_40422001_1 - 5.7e-26 90.7 0.1 2.8e-25 88.5 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001331059.1_40422001_1 - 4.2e-05 23.9 0.0 0.00013 22.4 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001331059.1_40422001_1 - 0.0011 19.0 0.0 0.0022 18.0 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain MHC_I PF00129.16 001331059.1_40422001_1 - 0.0012 18.3 0.2 0.0019 17.6 0.2 1.3 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C2-set_2 PF08205.10 001331059.1_40422001_1 - 0.0073 16.2 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain WWE PF02825.18 001331059.1_40422001_1 - 0.015 15.7 0.1 5 7.6 0.0 2.4 2 0 0 2 2 2 0 WWE domain Ig_2 PF13895.4 001331059.1_40422001_1 - 0.018 15.3 0.0 0.032 14.5 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain IL3 PF02059.13 001168737.1_40421001_1 - 2.2e-41 140.5 0.9 2.6e-41 140.3 0.9 1.0 1 0 0 1 1 1 1 Interleukin-3 MHC_II_alpha PF00993.18 001331060.1_40422001_1 - 6.9e-34 115.3 0.3 9.6e-34 114.8 0.3 1.2 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001331060.1_40422001_1 - 6.5e-29 99.0 0.3 1.2e-28 98.2 0.3 1.4 1 0 0 1 1 1 1 C1-set C-terminal domain C1-set PF07654.13 001331060.1_40422001_1 - 8e-24 83.8 0.0 1.3e-23 83.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001331060.1_40422001_1 - 5.1e-05 23.7 0.0 8.7e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Marek_A PF02124.13 001331060.1_40422001_1 - 0.0025 17.5 0.0 0.0036 17.0 0.0 1.2 1 0 0 1 1 1 1 Marek's disease glycoprotein A BRCT_assoc PF12820.5 001302103.1_40429001_1 - 4.6e-78 260.6 1.9 4.6e-78 260.6 1.9 3.5 3 0 0 3 3 2 1 Serine-rich domain associated with BRCT BRCT PF00533.24 001302103.1_40429001_1 - 5.2e-17 61.9 0.0 1.1e-08 35.3 0.0 3.3 3 0 0 3 3 2 2 BRCA1 C Terminus (BRCT) domain zf-C3HC4 PF00097.23 001302103.1_40429001_1 - 8.1e-10 38.3 10.1 3.2e-09 36.4 10.1 2.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001302103.1_40429001_1 - 3.9e-09 36.1 10.7 1.2e-08 34.6 10.7 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001302103.1_40429001_1 - 4.6e-08 33.0 10.3 1.5e-07 31.3 10.3 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 001302103.1_40429001_1 - 6.3e-07 29.0 7.6 1.6e-06 27.8 7.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001302103.1_40429001_1 - 1.4e-06 28.1 8.8 1.4e-06 28.1 8.8 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.4 001302103.1_40429001_1 - 2.2e-06 27.7 8.7 2.2e-06 27.7 8.7 2.6 3 0 0 3 3 1 1 Ring finger domain zf-RING_5 PF14634.4 001302103.1_40429001_1 - 1.7e-05 24.5 8.4 5.7e-05 22.9 8.4 2.0 1 0 0 1 1 1 1 zinc-RING finger domain zf-Nse PF11789.6 001302103.1_40429001_1 - 0.00013 21.5 7.1 0.00041 20.0 7.1 1.8 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.4 001302103.1_40429001_1 - 0.00049 19.8 2.3 0.0011 18.7 2.3 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.3 001302103.1_40429001_1 - 0.00086 19.3 5.6 0.0038 17.2 5.6 2.2 1 0 0 1 1 1 1 zinc RING finger of MSL2 Prok-RING_4 PF14447.4 001302103.1_40429001_1 - 0.0011 18.6 7.6 0.0042 16.8 7.6 2.1 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 BRCT_2 PF16589.3 001302103.1_40429001_1 - 0.0014 18.9 0.0 0.85 9.9 0.0 2.9 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain zf-ANAPC11 PF12861.5 001302103.1_40429001_1 - 0.0025 17.7 1.5 0.006 16.5 1.5 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.5 001302103.1_40429001_1 - 0.012 15.8 4.5 0.057 13.6 4.5 2.3 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.4 001302103.1_40429001_1 - 0.23 11.1 7.0 0.63 9.7 7.0 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3H2C3 PF17122.3 001302103.1_40429001_1 - 1.6 8.7 4.7 5.6 7.0 4.7 2.1 1 1 0 1 1 1 0 Zinc-finger KOG2701 PF09762.7 001168740.1_40424001_1 - 9.1e-78 260.4 0.0 9.1e-78 260.4 0.0 4.1 3 2 0 3 3 3 1 Coiled-coil domain-containing protein (DUF2037) DUF5082 PF16888.3 001168740.1_40424001_1 - 0.015 15.5 10.1 0.015 15.5 10.1 4.0 3 1 1 4 4 4 0 Domain of unknown function (DUF5082) DUF4107 PF13389.4 001168740.1_40424001_1 - 0.56 10.2 4.3 1.8 8.6 0.1 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF4107) NPV_P10 PF05531.10 001168740.1_40424001_1 - 2.3 8.6 5.9 2.1 8.7 0.9 3.5 3 1 0 4 4 4 0 Nucleopolyhedrovirus P10 protein DivIC PF04977.13 001168740.1_40424001_1 - 8.3 6.1 30.0 2.5 7.8 0.5 6.1 3 2 2 5 5 5 0 Septum formation initiator DUF846 PF05832.10 001281856.1_40424001_2 - 3.2e-55 185.8 9.5 7.7e-55 184.6 9.5 1.7 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) MHC_I PF00129.16 001331061.1_40423001_1 - 8.7e-95 315.2 2.3 1.2e-94 314.7 2.3 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001331061.1_40423001_1 - 3.1e-16 59.5 0.0 6.3e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001331061.1_40423001_1 - 1e-14 54.0 5.8 2e-14 53.0 5.8 1.4 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 001331061.1_40423001_1 - 3.5e-05 24.2 0.4 0.031 14.7 0.1 2.6 1 1 1 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001331061.1_40423001_1 - 0.00023 21.0 0.2 0.00044 20.1 0.2 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001331061.1_40423001_1 - 0.0049 16.9 0.0 0.013 15.5 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain bZIP_2 PF07716.13 001331061.1_40423001_3 - 0.086 12.8 0.8 0.15 12.0 0.8 1.4 1 0 0 1 1 1 0 Basic region leucine zipper V-set PF07686.15 001168743.1_40422001_1 - 2.6e-10 40.3 0.1 5.4e-10 39.3 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain Izumo-Ig PF16706.3 001168743.1_40422001_1 - 0.096 12.6 0.0 0.47 10.4 0.0 2.0 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain MITF_TFEB_C_3_N PF15951.3 001168746.1_40423001_1 - 5.8e-67 225.0 11.2 1.4e-66 223.7 11.2 1.7 1 0 0 1 1 1 1 MITF/TFEB/TFEC/TFE3 N-terminus DUF3371 PF11851.6 001168746.1_40423001_1 - 2.9e-35 121.9 6.3 2.9e-35 121.9 6.3 3.2 2 1 0 2 2 2 1 Domain of unknown function (DUF3371) HLH PF00010.24 001168746.1_40423001_1 - 1.5e-15 56.7 0.7 3.3e-15 55.6 0.7 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain HECT_2 PF09814.7 146809.1_26224120_1 - 2e-44 151.8 5.0 2.7e-44 151.5 5.0 1.1 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding HECT_2 PF09814.7 146809.1_26224120_2 - 4.4e-16 58.6 0.6 6e-16 58.1 0.6 1.1 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding ig PF00047.23 001042661.1_29624001_3 - 4.1e-23 81.2 0.0 1.4e-12 47.5 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001042661.1_29624001_3 - 2.1e-16 59.9 0.0 2.2e-09 37.4 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001042661.1_29624001_3 - 2.2e-10 40.8 0.0 0.00023 21.6 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 001042661.1_29624001_3 - 5.1e-05 23.2 0.0 0.24 11.4 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin V-set domain Pannexin_like PF12534.6 001257576.1_29627001_2 - 1.8e-144 481.0 1.8 2.3e-144 480.7 1.8 1.1 1 0 0 1 1 1 1 Pannexin-like TM region of LRRC8 LRR_8 PF13855.4 001257576.1_29627001_2 - 2.4e-28 97.6 41.0 7.8e-10 38.2 1.9 6.9 5 2 2 7 7 7 5 Leucine rich repeat LRR_4 PF12799.5 001257576.1_29627001_2 - 2.7e-26 90.9 44.6 3.5e-05 23.9 1.6 9.6 7 3 2 9 9 9 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001257576.1_29627001_2 - 5.7e-09 35.9 1.0 4e-05 23.5 0.9 3.2 1 1 3 4 4 4 3 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001257576.1_29627001_2 - 3.1e-07 29.9 17.8 0.00028 20.3 1.6 3.4 1 1 2 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.4 001257576.1_29627001_2 - 0.071 13.1 0.3 0.071 13.1 0.3 8.3 10 0 0 10 10 10 0 Leucine Rich repeat Pannexin_like PF12534.6 001257603.1_29629001_3 - 4.2e-151 502.8 3.8 5.5e-151 502.5 3.8 1.1 1 0 0 1 1 1 1 Pannexin-like TM region of LRRC8 LRR_8 PF13855.4 001257603.1_29629001_3 - 4.6e-23 80.6 33.7 7.8e-10 38.3 1.6 7.3 5 2 3 8 8 8 4 Leucine rich repeat LRR_4 PF12799.5 001257603.1_29629001_3 - 2.2e-16 59.5 34.9 0.0001 22.4 0.1 9.2 5 2 4 9 9 9 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001257603.1_29629001_3 - 0.021 14.2 14.3 0.35 10.2 1.0 3.7 1 1 3 5 5 5 0 Leucine-rich repeat Pannexin_like PF12534.6 001266553.1_29627001_2 - 3.3e-157 522.9 7.4 5.9e-157 522.1 7.4 1.4 1 1 0 1 1 1 1 Pannexin-like TM region of LRRC8 LRR_8 PF13855.4 001266553.1_29627001_2 - 1.2e-29 101.7 30.4 2.7e-10 39.7 1.7 6.8 3 2 5 8 8 8 5 Leucine rich repeat LRR_4 PF12799.5 001266553.1_29627001_2 - 3.1e-25 87.6 38.2 3.3e-05 24.0 0.7 8.5 4 2 5 10 10 10 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001266553.1_29627001_2 - 1.4e-09 37.6 16.0 9.3e-06 25.1 1.5 3.6 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.31 001266553.1_29627001_2 - 0.0031 17.6 36.5 7.7 7.3 0.1 10.4 10 2 0 10 10 10 3 Leucine Rich Repeat LRR_6 PF13516.4 001266553.1_29627001_2 - 6.6 6.9 42.9 1.3 9.1 0.1 9.0 10 0 0 10 10 10 0 Leucine Rich repeat Pannexin_like PF12534.6 001168980.1_40425001_1 - 1.1e-144 481.8 1.8 1.4e-144 481.4 1.8 1.1 1 0 0 1 1 1 1 Pannexin-like TM region of LRRC8 LRR_8 PF13855.4 001168980.1_40425001_1 - 4e-29 100.0 41.2 5.7e-10 38.7 1.9 7.0 6 2 0 7 7 7 4 Leucine rich repeat LRR_4 PF12799.5 001168980.1_40425001_1 - 3.2e-27 93.9 45.4 2.6e-05 24.3 1.6 9.7 7 3 3 10 10 10 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001168980.1_40425001_1 - 2e-09 37.4 0.9 2.9e-05 23.9 1.0 3.4 1 1 3 4 4 4 3 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001168980.1_40425001_1 - 1.2e-07 31.3 17.9 0.00021 20.7 1.7 3.5 1 1 2 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.4 001168980.1_40425001_1 - 0.054 13.4 0.3 0.054 13.4 0.3 8.8 10 0 0 10 10 10 0 Leucine Rich repeat MR_MLE_C PF13378.4 001243617.1_49824001_1 - 9.2e-55 185.5 0.0 1.3e-54 185.0 0.0 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.14 001243617.1_49824001_1 - 2.5e-11 43.7 0.0 4.3e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MAAL_C PF07476.9 001243617.1_49824001_1 - 0.015 14.4 0.2 0.036 13.1 0.0 1.7 2 0 0 2 2 2 0 Methylaspartate ammonia-lyase C-terminus 7tm_4 PF13853.4 147093.3_32926001_1 - 2.8e-115 384.7 23.6 3.9e-115 384.2 23.6 1.2 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 147093.3_32926001_1 - 1.7e-18 66.7 19.6 4.9e-18 65.2 19.6 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 147093.3_32926001_1 - 4.1e-08 32.8 5.9 4.1e-08 32.8 5.9 2.1 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srsx VWA PF00092.26 001281594.1_31328001_3 - 5e-85 284.0 0.1 4.7e-28 98.5 0.0 3.1 3 0 0 3 3 3 3 von Willebrand factor type A domain Collagen PF01391.16 001281594.1_31328001_3 - 5.1e-51 170.1 191.9 4.7e-09 35.7 26.1 7.3 1 1 5 6 6 6 5 Collagen triple helix repeat (20 copies) VWA_2 PF13519.4 001281594.1_31328001_3 - 7.5e-38 129.4 0.1 5.3e-16 59.1 0.0 3.4 3 0 0 3 3 3 3 von Willebrand factor type A domain VWA_3 PF13768.4 001281594.1_31328001_3 - 3.4e-09 36.6 0.0 0.0011 18.7 0.1 3.5 3 1 0 3 3 3 2 von Willebrand factor type A domain VWA_CoxE PF05762.12 001281594.1_31328001_3 - 8.1e-06 25.2 0.0 0.15 11.3 0.0 3.4 3 0 0 3 3 3 2 VWA domain containing CoxE-like protein Toprim_3 PF13362.4 001281594.1_31328001_3 - 0.1 12.8 0.1 1.2 9.4 0.0 2.3 2 0 0 2 2 2 0 Toprim domain YcaO PF02624.14 001281594.1_31328001_3 - 0.17 11.0 0.0 0.34 10.0 0.0 1.4 1 0 0 1 1 1 0 YcaO cyclodehydratase, ATP-ad Mg2+-binding ETF PF01012.19 001281594.1_31328001_3 - 0.18 11.5 0.1 0.34 10.6 0.1 1.3 1 0 0 1 1 1 0 Electron transfer flavoprotein domain 7tm_1 PF00001.19 001281359.1_31324001_2 - 9.8e-69 231.4 13.4 1.3e-68 231.0 13.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001281359.1_31324001_2 - 2.7e-15 56.3 17.8 3.9e-15 55.8 17.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001281359.1_31324001_2 - 1.2e-07 31.6 7.2 1.2e-07 31.6 7.2 2.0 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001281359.1_31324001_2 - 9.5e-05 21.7 15.9 9.5e-05 21.7 15.9 2.8 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Lipase PF00151.17 001281564.1_31323001_1 - 2.7e-130 434.4 0.0 3.7e-130 434.0 0.0 1.1 1 0 0 1 1 1 1 Lipase PLAT PF01477.21 001281564.1_31323001_1 - 1e-25 90.4 0.5 2e-25 89.5 0.5 1.5 1 0 0 1 1 1 1 PLAT/LH2 domain Abhydrolase_1 PF00561.18 001281564.1_31323001_1 - 1.9e-05 24.3 0.0 3.1e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001281564.1_31323001_1 - 0.00028 21.4 0.3 0.00045 20.8 0.3 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ank_4 PF13637.4 001281385.1_31321001_1 - 2.8e-17 62.7 0.0 7.6e-07 29.4 0.0 3.1 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 001281385.1_31321001_1 - 2.3e-11 43.6 1.7 0.00021 21.4 0.3 3.6 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 001281385.1_31321001_1 - 1.4e-10 41.5 0.0 9.9e-07 29.1 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.4 001281385.1_31321001_1 - 2.3e-06 27.3 0.0 2.9 8.6 0.0 3.7 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.28 001281385.1_31321001_1 - 1.3e-05 25.3 0.1 0.059 13.7 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Pkinase PF00069.23 001281588.1_31323001_1 - 4.4e-27 95.0 0.0 5.5e-27 94.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001281588.1_31323001_1 - 6e-17 61.7 0.0 7.5e-17 61.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 001281588.1_31323001_1 - 0.00017 21.4 0.2 0.0014 18.5 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.9 001281588.1_31323001_1 - 0.042 12.7 0.1 0.07 12.0 0.1 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.12 001281588.1_31323001_1 - 0.097 11.9 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family BSP_II PF05432.9 001281623.1_31324001_1 - 4.5e-130 433.6 61.7 5.3e-130 433.3 61.7 1.0 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) Utp14 PF04615.11 001281623.1_31324001_1 - 0.037 12.6 14.0 0.049 12.1 14.0 1.0 1 0 0 1 1 1 0 Utp14 protein RNA_polI_A34 PF08208.9 001281623.1_31324001_1 - 0.42 10.6 16.3 0.67 9.9 16.3 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Pro_isomerase PF00160.19 001281623.1_31324001_1 - 0.98 9.5 5.1 2.5 8.2 5.0 1.8 1 1 0 1 1 1 0 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SAPS PF04499.13 001281623.1_31324001_1 - 2.7 6.5 8.7 3.7 6.1 8.7 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Hid1 PF12722.5 001281623.1_31324001_1 - 3.6 5.4 12.3 5.1 4.9 12.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.15 001281623.1_31324001_1 - 3.9 6.0 13.7 7.1 5.1 13.7 1.4 1 0 0 1 1 1 0 Presenilin FAM176 PF14851.4 001281623.1_31324001_1 - 6.3 6.3 20.7 0.5 9.9 5.2 2.5 2 0 0 2 2 2 0 FAM176 family Tubulin-binding PF00418.17 001281879.1_31323001_1 - 1.2e-61 204.2 27.0 2.9e-17 62.2 3.3 5.4 5 0 0 5 5 5 5 Tau and MAP protein, tubulin-binding repeat Tmemb_cc2 PF10267.7 001281879.1_31323001_1 - 0.019 14.0 2.6 0.23 10.5 0.3 2.3 1 1 1 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein DPPIV_N PF00930.19 001310571.1_31325001_1 - 1.1e-109 366.3 6.3 1.4e-109 366.0 6.3 1.1 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.19 001310571.1_31325001_1 - 1.8e-59 200.6 2.1 1.8e-59 200.6 2.1 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family DLH PF01738.16 001310571.1_31325001_1 - 2.5e-06 27.1 0.0 5.8e-06 25.9 0.0 1.4 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.5 001310571.1_31325001_1 - 0.001 19.6 0.0 0.0047 17.5 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family LIP PF03583.12 001310571.1_31325001_1 - 0.001 18.3 0.1 0.0028 16.9 0.1 1.7 2 0 0 2 2 2 1 Secretory lipase Hydrolase_4 PF12146.6 001310571.1_31325001_1 - 0.0054 15.9 0.2 0.47 9.5 0.1 2.3 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.11 001310571.1_31325001_1 - 0.0075 16.0 0.2 0.11 12.2 0.2 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.14 001310571.1_31325001_1 - 0.0082 15.8 1.5 1.5 8.4 0.4 2.3 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase AXE1 PF05448.10 001310571.1_31325001_1 - 0.029 12.9 0.0 0.25 9.9 0.0 2.1 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) Peptidase_S15 PF02129.16 001310571.1_31325001_1 - 0.23 10.9 8.0 0.16 11.4 0.8 2.6 2 1 1 3 3 3 0 X-Pro dipeptidyl-peptidase (S15 family) zf-C4 PF00105.16 001281356.1_31326001_1 - 4.2e-32 110.3 16.2 4.2e-32 110.3 16.2 2.3 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001281356.1_31326001_1 - 2.1e-24 86.1 0.5 3.9e-24 85.2 0.0 1.7 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor Connexin PF00029.17 001281616.1_31323001_2 - 4.2e-93 311.1 2.9 5.8e-93 310.7 2.9 1.2 1 0 0 1 1 1 1 Connexin Connexin43 PF03508.11 001281616.1_31323001_2 - 6.2e-11 41.5 15.4 1.2e-10 40.5 15.4 1.5 1 0 0 1 1 1 1 Gap junction alpha-1 protein (Cx43) Connexin40_C PF16791.3 001281616.1_31323001_2 - 2.1e-05 25.6 1.6 3.5e-05 24.9 1.6 1.3 1 0 0 1 1 1 1 Connexin 40 C-terminal domain Ammonium_transp PF00909.19 001281616.1_31323001_2 - 0.13 10.8 0.1 0.2 10.2 0.1 1.2 1 0 0 1 1 1 0 Ammonium Transporter Family TEX29 PF15839.3 001281616.1_31323001_2 - 8 7.0 6.5 1.9 9.0 0.2 2.5 2 1 0 2 2 2 0 Testis-expressed sequence 29 protein CD36 PF01130.19 001281557.1_31323001_1 - 8.1e-157 522.3 4.5 9.4e-157 522.1 4.5 1.0 1 0 0 1 1 1 1 CD36 family DNA_ligase_A_M PF01068.19 001281557.1_31323001_1 - 0.046 13.2 0.0 0.08 12.4 0.0 1.3 1 0 0 1 1 1 0 ATP dependent DNA ligase domain DUF3309 PF11752.6 001281557.1_31323001_2 - 0.2 11.6 0.0 0.38 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3309) DEAD PF00270.27 001281387.1_31324001_1 - 4.4e-51 173.0 0.0 1.6e-50 171.2 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001281387.1_31324001_1 - 1.7e-31 108.7 0.0 3.6e-31 107.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 001281387.1_31324001_1 - 0.00061 19.7 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.10 001281387.1_31324001_1 - 0.011 14.4 0.0 0.023 13.3 0.0 1.4 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 HpcH_HpaI PF03328.12 001281387.1_31324001_2 - 0.15 11.0 8.6 1.1 8.3 3.5 2.1 2 0 0 2 2 2 0 HpcH/HpaI aldolase/citrate lyase family Oxysterol_BP PF01237.16 001281672.1_31328001_3 - 2.3e-92 309.6 1.3 4.1e-90 302.2 1.3 2.2 1 1 0 1 1 1 1 Oxysterol-binding protein PH PF00169.27 001281672.1_31328001_3 - 3.7e-09 36.9 0.1 4.2e-08 33.5 0.0 2.5 2 0 0 2 2 2 1 PH domain zf-C2H2 PF00096.24 001281704.1_31329001_2 - 5.6e-42 139.8 72.0 7.1e-05 22.9 0.8 12.9 12 0 0 12 12 12 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001281704.1_31329001_2 - 1.6e-26 90.6 71.6 0.012 16.3 1.1 13.1 13 0 0 13 13 13 11 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001281704.1_31329001_2 - 1e-13 50.7 77.3 0.019 14.8 0.4 12.5 12 0 0 12 12 12 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001281704.1_31329001_2 - 0.00011 22.1 50.0 2.2 8.3 0.1 12.2 12 0 0 12 12 12 5 Zinc ribbon domain Zf_RING PF16744.3 001281704.1_31329001_2 - 0.0031 17.4 17.4 4.1 7.4 0.1 7.1 7 0 0 7 7 7 1 KIAA1045 RING finger zf-C2H2_jaz PF12171.6 001281704.1_31329001_2 - 0.018 15.2 46.6 0.71 10.1 0.0 9.7 10 0 0 10 10 10 0 Zinc-finger double-stranded RNA-binding DUF1970 PF09301.8 001281704.1_31329001_2 - 0.062 13.4 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1970) zf-H2C2_2 PF13465.4 001281704.1_31329001_2 - 0.063 13.6 93.4 0.11 12.9 0.4 16.9 18 1 0 18 18 17 0 Zinc-finger double domain Lar_restr_allev PF14354.4 001281704.1_31329001_2 - 0.12 12.7 0.1 0.12 12.7 0.1 7.7 8 2 1 9 9 9 0 Restriction alleviation protein Lar zf-C2H2_8 PF15909.3 001281704.1_31329001_2 - 0.32 11.2 28.0 17 5.6 0.0 9.0 7 2 2 9 9 9 0 C2H2-type zinc ribbon Yippee-Mis18 PF03226.12 001281704.1_31329001_2 - 1.8 8.7 18.6 7.4 6.7 0.2 6.6 6 1 1 7 7 7 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Baculo_IE-1 PF05290.9 001281704.1_31329001_2 - 2.2 8.1 15.1 13 5.6 0.1 6.4 8 0 0 8 8 8 0 Baculovirus immediate-early protein (IE-0) Ferrochelatase PF00762.17 001281395.1_31325001_2 - 4.2e-109 364.3 0.0 5.3e-109 364.0 0.0 1.1 1 0 0 1 1 1 1 Ferrochelatase Eapp_C PF10238.7 001281395.1_31325001_2 - 0.15 12.0 0.4 0.28 11.1 0.4 1.4 1 0 0 1 1 1 0 E2F-associated phosphoprotein 7tm_1 PF00001.19 001310563.1_31323001_1 - 1.3e-34 119.6 20.1 1.7e-34 119.2 20.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 001310563.1_31323001_1 - 0.0052 16.0 10.8 0.007 15.6 10.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_2 PF00002.22 001281408.1_31324001_1 - 2.4e-79 266.0 14.5 4.1e-79 265.2 14.5 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 001281408.1_31324001_1 - 3.4e-14 52.8 6.9 6.8e-14 51.8 6.9 1.5 1 0 0 1 1 1 1 Hormone receptor domain Cys_knot PF00007.20 001281370.1_31322001_2 - 1.1e-31 109.0 3.0 1.4e-31 108.8 3.0 1.1 1 0 0 1 1 1 1 Cystine-knot domain DUF3772 PF12607.6 001281370.1_31322001_3 - 0.018 14.7 2.5 0.042 13.5 2.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3772) VWA PF00092.26 001281549.1_31328001_1 - 9.1e-93 309.2 2.2 6.1e-31 107.9 0.1 3.1 3 0 0 3 3 3 3 von Willebrand factor type A domain Collagen PF01391.16 001281549.1_31328001_1 - 9.1e-50 166.1 215.1 1e-09 37.9 26.1 7.2 1 1 5 6 6 6 6 Collagen triple helix repeat (20 copies) VWA_2 PF13519.4 001281549.1_31328001_1 - 1.5e-38 131.6 0.4 4.2e-13 49.8 0.0 3.3 3 0 0 3 3 3 3 von Willebrand factor type A domain VWA_3 PF13768.4 001281549.1_31328001_1 - 0.00028 20.7 0.7 0.65 9.7 0.1 4.3 4 2 0 4 4 4 2 von Willebrand factor type A domain AA_permease_2 PF13520.4 001310565.1_31324001_1 - 3.7e-43 147.8 16.7 3.7e-43 147.8 16.7 2.1 2 0 0 2 2 2 1 Amino acid permease AA_permease PF00324.19 001310565.1_31324001_1 - 8.5e-37 126.7 18.9 8.5e-37 126.7 18.9 2.2 2 0 0 2 2 2 1 Amino acid permease AA_permease_C PF13906.4 001310565.1_31324001_1 - 3.5e-25 87.7 7.1 3.5e-25 87.7 7.1 3.1 4 0 0 4 4 4 1 C-terminus of AA_permease 7tm_1 PF00001.19 001281403.1_31323001_1 - 8.9e-62 208.6 12.6 1.2e-61 208.1 12.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001281403.1_31323001_1 - 8.2e-14 51.5 11.0 1e-13 51.1 11.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 001281403.1_31323001_1 - 1.9e-11 43.7 2.8 1.9e-11 43.7 2.8 1.7 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 001281403.1_31323001_1 - 9.4e-09 35.3 14.4 1.5e-07 31.3 14.4 2.0 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001281403.1_31323001_1 - 0.00019 20.7 10.4 0.00019 20.7 10.4 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx V1R PF03402.12 001281403.1_31323001_1 - 2.3 7.6 9.7 0.78 9.2 0.2 2.9 2 1 0 3 3 3 0 Vomeronasal organ pheromone receptor family, V1R EI24 PF07264.9 001281403.1_31323001_1 - 8 6.5 18.0 1.2e+03 -0.6 18.0 2.5 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) IL8 PF00048.18 001281699.1_31321001_3 - 1.4e-21 76.3 0.4 2.2e-21 75.6 0.4 1.3 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like zf-C4 PF00105.16 001281684.1_31326001_2 - 1.8e-32 111.4 16.0 1.8e-32 111.4 16.0 2.0 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001281684.1_31326001_2 - 2e-21 76.4 0.0 3.4e-21 75.7 0.0 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor FA_desaturase PF00487.22 001281586.1_31323001_1 - 3.6e-15 56.4 15.5 3.6e-15 56.4 15.5 1.5 1 1 1 2 2 2 1 Fatty acid desaturase VWA PF00092.26 001281875.1_31329001_1 - 4.9e-289 948.4 13.1 6.8e-41 140.3 0.1 9.1 9 0 0 9 9 9 9 von Willebrand factor type A domain VWA_2 PF13519.4 001281875.1_31329001_1 - 1.3e-83 276.5 4.5 3.2e-11 43.7 0.0 9.5 9 0 0 9 9 9 8 von Willebrand factor type A domain Collagen PF01391.16 001281875.1_31329001_1 - 4.5e-43 144.7 177.1 2.5e-08 33.4 23.3 6.6 2 1 4 6 6 6 6 Collagen triple helix repeat (20 copies) Kunitz_BPTI PF00014.21 001281875.1_31329001_1 - 3.6e-18 65.4 8.1 6.8e-18 64.5 8.1 1.5 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain VWA_3 PF13768.4 001281875.1_31329001_1 - 4.2e-18 65.6 6.5 5.9e-05 22.9 0.0 8.1 8 0 0 8 8 8 5 von Willebrand factor type A domain fn3 PF00041.19 001281875.1_31329001_1 - 7e-06 26.2 0.7 1.8e-05 24.8 0.7 1.6 1 0 0 1 1 1 1 Fibronectin type III domain Med25_VWA PF11265.6 001281875.1_31329001_1 - 0.0061 16.3 0.0 15 5.2 0.0 4.0 4 0 0 4 4 4 2 Mediator complex subunit 25 von Willebrand factor type A p450 PF00067.20 001281610.1_31324001_2 - 1.1e-150 502.3 0.3 1.3e-150 502.1 0.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 CARD_2 PF16739.3 001310575.1_31327001_1 - 1.5e-39 133.7 0.0 6.9e-19 67.5 0.0 2.7 2 0 0 2 2 2 2 Caspase recruitment domain RIG-I_C-RD PF11648.6 001310575.1_31327001_1 - 2.9e-38 130.6 4.0 2.9e-38 130.6 4.0 2.1 2 0 0 2 2 2 1 C-terminal domain of RIG-I Helicase_C PF00271.29 001310575.1_31327001_1 - 2.7e-21 75.9 2.4 4.5e-20 71.9 0.4 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.13 001310575.1_31327001_1 - 2.1e-19 70.0 0.0 2.1e-19 70.0 0.0 2.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.27 001310575.1_31327001_1 - 1.5e-17 63.8 0.0 5e-17 62.1 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase CARD PF00619.19 001310575.1_31327001_1 - 7.2e-17 61.1 0.0 1.3e-12 47.4 0.1 2.7 2 0 0 2 2 2 2 Caspase recruitment domain AAA_22 PF13401.4 001310575.1_31327001_1 - 0.0019 18.4 0.5 0.031 14.4 0.1 3.2 3 1 0 3 3 3 1 AAA domain DUF3638 PF12340.6 001310575.1_31327001_1 - 0.011 14.9 0.0 0.022 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3638) AAA_19 PF13245.4 001310575.1_31327001_1 - 0.014 15.6 0.0 0.068 13.4 0.0 2.2 1 1 0 1 1 1 0 AAA domain PAS_3 PF08447.10 001281658.1_31327001_2 - 4.7e-19 68.3 0.2 9.2e-13 48.2 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS PF00989.23 001281658.1_31327001_2 - 9.3e-15 54.5 0.1 1.1e-12 47.8 0.0 2.7 2 0 0 2 2 2 1 PAS fold PAS_11 PF14598.4 001281658.1_31327001_2 - 1.3e-10 41.2 4.8 1.4e-08 34.7 0.0 3.2 3 0 0 3 3 3 2 PAS domain HLH PF00010.24 001281658.1_31327001_2 - 1.3e-05 24.9 0.2 2.8e-05 23.9 0.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_4 PF08448.8 001281658.1_31327001_2 - 0.0012 19.0 0.1 0.099 12.8 0.0 2.8 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.5 001281658.1_31327001_2 - 0.09 12.9 0.0 0.38 10.9 0.0 2.0 2 0 0 2 2 2 0 PAS domain APOBEC_N PF08210.9 001281656.1_31322001_2 - 4.6e-30 104.8 0.2 6.5e-30 104.3 0.2 1.2 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001281656.1_31322001_2 - 3.9e-23 81.1 0.2 6.9e-23 80.3 0.2 1.4 1 0 0 1 1 1 1 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 001281656.1_31322001_2 - 0.014 15.1 0.0 0.022 14.5 0.0 1.3 1 0 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region Toxin-deaminase PF14424.4 001281656.1_31322001_2 - 0.21 11.5 0.3 0.34 10.9 0.0 1.5 2 0 0 2 2 2 0 The BURPS668_1122 family of deaminases Neuregulin PF02158.13 001281881.1_31325001_1 - 1.8e-106 356.8 6.8 1.8e-106 356.8 6.8 1.8 2 0 0 2 2 2 1 Neuregulin family I-set PF07679.14 001281881.1_31325001_1 - 4.2e-14 52.3 0.2 1.1e-13 51.0 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001281881.1_31325001_1 - 1.4e-10 41.5 2.4 1.5e-10 41.4 0.0 2.3 3 0 0 3 3 2 1 Immunoglobulin domain Ig_2 PF13895.4 001281881.1_31325001_1 - 2.5e-09 37.2 0.2 1.7e-08 34.6 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001281881.1_31325001_1 - 3.3e-09 36.7 0.0 8.3e-09 35.4 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 001281881.1_31325001_1 - 3e-05 24.0 0.1 0.00046 20.2 0.1 2.4 1 1 0 1 1 1 1 Immunoglobulin V-set domain EGF PF00008.25 001281881.1_31325001_1 - 0.00013 22.0 2.9 0.00013 22.0 2.9 2.2 2 0 0 2 2 2 1 EGF-like domain hEGF PF12661.5 001281881.1_31325001_1 - 0.0026 18.2 2.2 0.024 15.2 2.2 2.9 1 0 0 1 1 1 1 Human growth factor-like EGF C1-set PF07654.13 001281881.1_31325001_1 - 0.0064 16.8 0.0 0.022 15.1 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin C1-set domain EGF_2 PF07974.11 001281881.1_31325001_1 - 0.0083 16.3 2.2 0.028 14.7 2.2 2.0 1 1 0 1 1 1 1 EGF-like domain BiPBP_C PF06832.10 001281881.1_31325001_1 - 0.046 13.6 0.3 0.12 12.3 0.0 1.7 2 0 0 2 2 1 0 Penicillin-Binding Protein C-terminus Family C2-set_2 PF08205.10 001281881.1_31325001_1 - 0.11 12.4 0.0 0.11 12.4 0.0 2.6 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain Laminin_EGF PF00053.22 001281881.1_31325001_1 - 0.48 10.5 3.8 1.4 9.0 3.8 1.8 1 0 0 1 1 1 0 Laminin EGF domain EGF_3 PF12947.5 001281881.1_31325001_1 - 2.5 8.2 5.3 7.6 6.7 5.3 1.9 1 0 0 1 1 1 0 EGF domain Neuregulin PF02158.13 001281881.1_31325001_2 - 7.5e-69 232.9 9.5 1.1e-68 232.4 9.5 1.1 1 0 0 1 1 1 1 Neuregulin family Insulin PF00049.16 001281833.1_31322001_1 - 4.2e-15 56.4 4.2 1.6e-07 32.1 1.4 2.6 1 1 1 2 2 2 2 Insulin/IGF/Relaxin family Hormone_1 PF00103.18 001281652.1_31322001_2 - 1.4e-63 214.3 0.0 1.7e-63 214.1 0.0 1.0 1 0 0 1 1 1 1 Somatotropin hormone family PROCN PF08083.9 001281652.1_31322001_3 - 0.049 12.2 0.0 0.068 11.7 0.0 1.1 1 0 0 1 1 1 0 PROCN (NUC071) domain Lectin_C PF00059.19 001281579.1_31322001_3 - 1.9e-20 73.5 0.1 2.6e-20 73.0 0.1 1.2 1 0 0 1 1 1 1 Lectin C-type domain Trypsin_2 PF13365.4 001281566.1_31323001_1 - 2.6e-32 112.7 0.4 8.2e-32 111.0 0.1 1.9 2 0 0 2 2 2 1 Trypsin-like peptidase domain Trypsin PF00089.24 001281566.1_31323001_1 - 1.5e-15 57.4 0.0 3.4e-15 56.3 0.0 1.5 2 0 0 2 2 2 1 Trypsin IGFBP PF00219.16 001281566.1_31323001_1 - 9.6e-11 42.0 26.0 9.6e-11 42.0 26.0 1.9 2 0 0 2 2 2 1 Insulin-like growth factor binding protein PDZ PF00595.22 001281566.1_31323001_1 - 2.3e-10 40.5 0.6 5.8e-10 39.3 0.2 1.9 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) Kazal_2 PF07648.13 001281566.1_31323001_1 - 2.5e-09 37.0 0.5 6e-09 35.8 0.5 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain PDZ_2 PF13180.4 001281566.1_31323001_1 - 8.9e-09 35.4 0.3 2.3e-08 34.1 0.3 1.7 1 0 0 1 1 1 1 PDZ domain Kazal_1 PF00050.19 001281566.1_31323001_1 - 2.1e-06 27.5 0.2 6.7e-06 25.9 0.2 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Peptidase_S46 PF10459.7 001281566.1_31323001_1 - 2.9e-06 26.1 0.4 0.04 12.5 0.0 2.1 2 0 0 2 2 2 2 Peptidase S46 Peptidase_S32 PF05579.11 001281566.1_31323001_1 - 6.9e-05 22.1 0.3 0.17 10.9 0.0 2.2 1 1 0 2 2 2 2 Equine arteritis virus serine endopeptidase S32 LSM PF01423.20 001281566.1_31323001_1 - 0.032 13.8 1.0 0.057 13.0 0.1 1.8 2 0 0 2 2 2 0 LSM domain GRASP55_65 PF04495.12 001281566.1_31323001_1 - 0.081 13.1 0.1 0.17 12.0 0.1 1.5 1 0 0 1 1 1 0 GRASP55/65 PDZ-like domain Pkinase PF00069.23 001281592.1_31324001_2 - 2.1e-57 194.4 0.0 2.6e-57 194.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001281592.1_31324001_2 - 1.6e-34 119.2 0.0 2.3e-34 118.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001281592.1_31324001_2 - 5.8e-11 42.1 0.0 2.1e-10 40.3 0.0 1.7 1 1 1 2 2 2 1 Kinase-like APH PF01636.21 001281592.1_31324001_2 - 0.034 13.9 0.0 1.1 9.0 0.0 2.3 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.12 001281592.1_31324001_2 - 0.051 12.8 0.3 0.26 10.5 0.3 1.9 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Asn_synthase PF00733.19 001281614.1_31325001_2 - 1.2e-83 281.6 0.7 1.1e-45 156.7 0.1 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.4 001281614.1_31325001_2 - 2e-25 89.0 0.0 3.7e-25 88.1 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.4 001281614.1_31325001_2 - 9.3e-20 71.1 0.0 1.9e-19 70.0 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.6 001281614.1_31325001_2 - 1.1e-06 28.1 0.0 2.2e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Aluminium induced protein tRNA_Me_trans PF03054.14 001281614.1_31325001_2 - 0.0093 14.7 0.0 0.014 14.1 0.0 1.2 1 0 0 1 1 1 1 tRNA methyl transferase QueC PF06508.11 001281614.1_31325001_2 - 0.024 14.0 0.0 0.043 13.2 0.0 1.4 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC NAD_synthase PF02540.15 001281614.1_31325001_2 - 0.046 12.7 0.0 0.068 12.1 0.0 1.2 1 0 0 1 1 1 0 NAD synthase ThiI PF02568.12 001281614.1_31325001_2 - 0.16 11.4 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) Aldo_ket_red PF00248.19 001281598.1_31323001_2 - 1.6e-52 178.4 0.0 2e-52 178.1 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Biopterin_H PF00351.19 001310557.1_31324001_1 - 3e-169 562.2 0.0 3.7e-169 561.9 0.0 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.23 001310557.1_31324001_1 - 3.1e-05 23.5 0.0 6.1e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 ACT domain MIF4G PF02854.17 001281605.1_31329001_1 - 1.6e-68 230.4 10.3 3.1e-68 229.5 10.3 1.5 1 0 0 1 1 1 1 MIF4G domain MA3 PF02847.15 001281605.1_31329001_1 - 9.3e-30 102.8 0.4 8e-29 99.8 0.1 2.6 2 1 0 2 2 2 1 MA3 domain W2 PF02020.16 001281605.1_31329001_1 - 5.3e-19 68.0 2.0 2e-18 66.1 2.0 2.1 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Cep57_MT_bd PF06657.11 001281605.1_31329001_1 - 0.12 12.7 3.0 0.77 10.1 3.0 2.4 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 Pkinase_Tyr PF07714.15 001310568.1_31324001_1 - 1.9e-94 315.6 0.0 2.4e-94 315.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001310568.1_31324001_1 - 4.5e-47 160.5 0.0 6.2e-47 160.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 001310568.1_31324001_1 - 1.7e-24 85.5 0.0 3.4e-24 84.6 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 001310568.1_31324001_1 - 8.6e-14 50.7 0.3 2.4e-13 49.3 0.0 2.0 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 001310568.1_31324001_1 - 1e-08 34.6 0.0 2.7e-08 33.2 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 001310568.1_31324001_1 - 1.2e-08 34.5 0.2 4.6e-08 32.7 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain Kdo PF06293.12 001310568.1_31324001_1 - 0.11 11.7 0.0 0.23 10.6 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family 7tm_1 PF00001.19 001319637.1_31323001_1 - 7.4e-34 117.1 20.8 1.1e-33 116.6 20.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4870 PF09685.8 001319637.1_31323001_1 - 0.018 15.0 3.1 0.018 15.0 3.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4870) SpoIIM PF01944.15 001319637.1_31323001_1 - 0.074 12.9 7.7 0.057 13.3 5.8 1.9 1 1 0 1 1 1 0 Stage II sporulation protein M DUF2678 PF10856.6 001319637.1_31323001_1 - 2.2 8.1 10.9 0.28 11.0 4.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2678) Sec62 PF03839.14 001319637.1_31323001_1 - 4 6.8 5.6 0.51 9.7 0.9 1.9 2 0 0 2 2 2 0 Translocation protein Sec62 7tm_1 PF00001.19 001281405.1_31324001_1 - 3.1e-47 160.9 19.6 3.8e-47 160.6 19.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001281405.1_31324001_1 - 5.9e-05 22.4 20.5 8.7e-05 21.9 20.5 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx IL8 PF00048.18 001281338.1_31321001_3 - 1.8e-19 69.5 0.1 3.4e-19 68.6 0.1 1.5 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Cyt-b5 PF00173.26 001281399.1_31322001_3 - 2.7e-22 78.5 0.1 3.9e-22 78.0 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Far-17a_AIG1 PF04750.12 001310573.1_31324001_3 - 6.2e-58 195.3 12.1 8.6e-58 194.8 12.1 1.2 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein Rab5ip PF07019.10 001310573.1_31324001_3 - 0.16 12.4 5.2 0.26 11.8 1.5 2.7 3 0 0 3 3 3 0 Rab5-interacting protein (Rab5ip) SAA PF00277.16 001310558.1_31322001_3 - 1.4e-52 176.3 5.6 1.6e-52 176.1 5.6 1.1 1 0 0 1 1 1 1 Serum amyloid A protein CARD_2 PF16739.3 001310553.1_31326001_1 - 6.5e-54 179.8 0.7 4.3e-27 93.8 0.0 2.6 2 0 0 2 2 2 2 Caspase recruitment domain RIG-I_C-RD PF11648.6 001310553.1_31326001_1 - 4.2e-36 123.6 4.5 4.2e-36 123.6 4.5 2.8 3 0 0 3 3 3 1 C-terminal domain of RIG-I ResIII PF04851.13 001310553.1_31326001_1 - 1.2e-17 64.3 0.1 1.1e-15 57.9 0.0 3.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.29 001310553.1_31326001_1 - 1.5e-17 63.8 0.0 5.1e-16 58.9 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.27 001310553.1_31326001_1 - 2e-16 60.1 0.6 8.1e-16 58.1 0.0 2.4 3 1 0 3 3 3 1 DEAD/DEAH box helicase AAA_19 PF13245.4 001310553.1_31326001_1 - 0.014 15.6 0.0 4.5 7.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.4 001310553.1_31326001_1 - 0.023 14.9 2.1 1.1 9.4 0.0 3.5 2 1 1 3 3 3 0 AAA domain AAA_25 PF13481.4 001310553.1_31326001_1 - 0.04 13.4 0.0 0.088 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.23 001310553.1_31326001_1 - 0.18 11.3 0.0 0.33 10.4 0.0 1.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_23 PF13476.4 001310553.1_31326001_1 - 2.2 8.6 8.4 12 6.2 1.0 3.1 3 0 0 3 3 3 0 AAA domain Kelch_1 PF01344.23 001281636.1_31329001_1 - 2.5e-27 94.0 9.5 1.2e-05 24.7 0.1 7.3 7 0 0 7 7 7 6 Kelch motif Lectin_C PF00059.19 001281636.1_31329001_1 - 3e-21 76.1 0.3 3e-21 76.1 0.3 3.2 3 0 0 3 3 1 1 Lectin C-type domain Kelch_6 PF13964.4 001281636.1_31329001_1 - 4.3e-19 67.9 8.4 4e-06 26.8 0.0 6.7 6 0 0 6 6 6 5 Kelch motif PSI PF01437.23 001281636.1_31329001_1 - 5.8e-17 61.8 56.2 1.6e-12 47.6 11.7 8.7 8 1 0 8 8 5 5 Plexin repeat Kelch_5 PF13854.4 001281636.1_31329001_1 - 1.6e-16 59.7 20.6 7e-05 22.6 0.1 6.4 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.4 001281636.1_31329001_1 - 8.3e-16 57.5 5.9 0.16 11.8 0.1 7.4 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.13 001281636.1_31329001_1 - 1.5e-14 53.1 8.9 0.12 12.3 0.1 6.8 6 0 0 6 6 6 5 Kelch motif CUB PF00431.18 001281636.1_31329001_1 - 6.6e-14 52.0 0.0 2.2e-13 50.4 0.0 2.0 1 0 0 1 1 1 1 CUB domain Kelch_3 PF13415.4 001281636.1_31329001_1 - 7.5e-14 51.5 6.2 0.15 12.2 0.0 7.5 6 0 0 6 6 6 3 Galactose oxidase, central domain Laminin_EGF PF00053.22 001281636.1_31329001_1 - 0.0015 18.5 16.6 0.0015 18.5 16.6 9.5 8 2 2 10 10 5 3 Laminin EGF domain EGF_2 PF07974.11 001281636.1_31329001_1 - 0.0056 16.9 12.4 0.0056 16.9 12.4 10.2 8 1 0 8 8 6 3 EGF-like domain PSI_integrin PF17205.1 001281636.1_31329001_1 - 0.0068 16.1 9.2 0.0068 16.1 9.2 6.7 6 0 0 6 6 4 3 Integrin plexin domain TMEM100 PF16311.3 001281636.1_31329001_1 - 0.018 14.5 0.3 0.045 13.2 0.3 1.6 1 0 0 1 1 1 0 Transmembrane protein 100 7tm_3 PF00003.20 001281636.1_31329001_1 - 0.2 11.3 3.1 0.6 9.7 3.1 1.8 1 0 0 1 1 1 0 7 transmembrane sweet-taste receptor of 3 GCPR PAS_3 PF08447.10 001281417.1_31325001_1 - 2.8e-24 85.1 0.0 3.7e-18 65.4 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS PF00989.23 001281417.1_31325001_1 - 3.8e-23 81.5 0.1 6e-15 55.1 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 001281417.1_31325001_1 - 1.4e-22 79.8 0.3 5.5e-20 71.4 0.1 2.8 2 1 0 2 2 2 2 PAS domain HLH PF00010.24 001281417.1_31325001_1 - 4.1e-15 55.3 1.1 8.8e-15 54.3 1.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.5 001281417.1_31325001_1 - 3e-09 36.9 0.0 3.8e-06 27.0 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.8 001281417.1_31325001_1 - 0.00087 19.4 0.0 0.83 9.8 0.0 2.7 2 0 0 2 2 2 2 PAS fold LRR_9 PF14580.4 001282122.1_31322001_3 - 3.4e-12 46.1 0.0 2.2e-11 43.5 0.0 1.9 1 1 1 2 2 2 1 Leucine-rich repeat LRR_8 PF13855.4 001282122.1_31322001_3 - 2.3e-07 30.3 2.9 2.3e-07 30.3 2.9 2.4 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.5 001282122.1_31322001_3 - 6e-06 26.4 7.8 0.0087 16.3 0.4 3.6 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001282122.1_31322001_3 - 0.84 10.2 7.4 50 4.8 0.2 4.3 4 0 0 4 4 4 0 Leucine Rich Repeat Pkinase PF00069.23 001281946.1_31324001_3 - 3.6e-54 183.7 0.2 9.3e-54 182.4 0.2 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001281946.1_31324001_3 - 2.9e-33 115.1 1.4 5.2e-33 114.3 0.0 2.1 2 1 0 2 2 2 1 Protein tyrosine kinase dsrm PF00035.24 001281946.1_31324001_3 - 5.5e-26 90.9 8.9 1.1e-13 51.5 0.0 3.5 3 0 0 3 3 3 2 Double-stranded RNA binding motif DND1_DSRM PF14709.5 001281946.1_31324001_3 - 0.003 17.7 2.7 0.11 12.6 0.0 3.2 2 1 0 2 2 2 1 double strand RNA binding domain from DEAD END PROTEIN 1 Kdo PF06293.12 001281946.1_31324001_3 - 0.0038 16.5 0.0 0.0088 15.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 001281946.1_31324001_3 - 0.013 14.7 0.0 0.03 13.5 0.0 1.6 1 0 0 1 1 1 0 Kinase-like ABC1 PF03109.14 001281946.1_31324001_3 - 0.03 14.4 0.0 0.073 13.1 0.0 1.6 1 0 0 1 1 1 0 ABC1 family LPP20 PF02169.14 001281946.1_31324001_3 - 0.84 9.9 3.2 1.1 9.5 0.1 2.4 2 0 0 2 2 2 0 LPP20 lipoprotein Cys_knot PF00007.20 001281604.1_31324001_3 - 8.5e-34 115.9 15.6 1.3e-33 115.3 15.6 1.3 1 0 0 1 1 1 1 Cystine-knot domain 7tm_1 PF00001.19 001281647.1_31323001_1 - 1e-46 159.2 27.0 1.8e-46 158.4 27.0 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001281647.1_31323001_1 - 3e-08 33.2 26.8 4.2e-08 32.7 26.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Serpentine_r_xa PF03383.13 001281647.1_31323001_1 - 0.0066 16.3 1.7 0.0066 16.3 1.7 2.6 1 1 1 2 2 2 2 Caenorhabditis serpentine receptor-like protein, class xa 7TM_GPCR_Srx PF10328.7 001281647.1_31323001_1 - 0.12 11.5 29.8 0.35 10.0 29.8 1.8 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx IL12 PF03039.12 001281367.1_31323001_2 - 5.2e-96 320.1 5.3 7e-96 319.7 5.3 1.1 1 0 0 1 1 1 1 Interleukin-12 alpha subunit HisKA_3 PF07730.11 001281367.1_31323001_2 - 0.12 12.7 0.1 0.3 11.5 0.1 1.6 1 0 0 1 1 1 0 Histidine kinase Sod_Cu PF00080.18 001281601.1_31324001_3 - 2.4e-31 108.6 0.0 3.4e-31 108.2 0.0 1.2 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) ODC_AZ PF02100.15 001290055.1_31324001_1 - 1.1e-19 70.4 0.0 1.7e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Alk_phosphatase PF00245.18 001290262.1_31324001_1 - 1.5e-179 597.2 0.8 1.7e-179 597.0 0.8 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.16 001290262.1_31324001_1 - 0.00043 19.6 0.0 0.001 18.4 0.0 1.7 1 1 0 1 1 1 1 Metalloenzyme superfamily Ig_2 PF13895.4 001281335.1_31322001_2 - 5.4e-19 68.2 5.3 1.8e-08 34.5 0.2 3.0 3 0 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.4 001281335.1_31322001_2 - 1.3e-17 64.0 7.2 3.7e-09 36.9 0.4 3.1 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.23 001281335.1_31322001_2 - 3.1e-09 36.8 7.1 0.0012 18.8 0.4 3.6 3 1 0 3 3 3 2 Immunoglobulin domain Ig_4 PF16680.3 001281335.1_31322001_2 - 9.5e-09 35.4 0.6 0.0021 18.3 0.1 2.3 2 0 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain I-set PF07679.14 001281335.1_31322001_2 - 4.6e-08 32.9 4.2 0.00044 20.1 0.2 4.3 3 2 0 3 3 3 2 Immunoglobulin I-set domain V-set PF07686.15 001281335.1_31322001_2 - 5.3e-07 29.6 8.6 0.46 10.5 0.0 5.1 3 2 2 5 5 5 3 Immunoglobulin V-set domain Ig_5 PF16681.3 001281335.1_31322001_2 - 1.2e-05 25.5 1.8 0.016 15.5 0.1 2.8 3 0 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Gastrin PF00918.15 001281707.1_31322001_3 - 6.3e-39 133.7 0.0 9.2e-39 133.1 0.0 1.2 1 0 0 1 1 1 1 Gastrin/cholecystokinin family Methyltransf_3 PF01596.15 001282123.1_31323001_3 - 1.2e-13 50.6 0.0 1.8e-13 50.1 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.4 001282123.1_31323001_3 - 1e-10 42.5 0.0 2e-10 41.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.17 001282123.1_31323001_3 - 0.0078 15.9 0.0 0.011 15.3 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.4 001282123.1_31323001_3 - 0.02 14.5 0.0 0.031 13.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Hormone_6 PF00236.16 001281665.1_31322001_1 - 1.1e-51 172.6 10.4 1.6e-51 172.1 10.4 1.3 1 0 0 1 1 1 1 Glycoprotein hormone DUF1218 PF06749.10 001281665.1_31322001_1 - 0.23 11.8 4.2 0.3 11.5 2.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) C2-set_2 PF08205.10 001281419.1_31325001_2 - 1.2e-20 73.2 0.0 2.2e-20 72.4 0.0 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain V-set PF07686.15 001281419.1_31325001_2 - 1.2e-08 35.0 0.4 2.9e-08 33.7 0.1 1.7 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001281419.1_31325001_2 - 4.8e-08 33.4 0.4 0.037 14.5 0.0 3.3 2 1 1 3 3 3 2 Immunoglobulin domain I-set PF07679.14 001281419.1_31325001_2 - 1.9e-06 27.7 0.0 0.00069 19.5 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 001281419.1_31325001_2 - 1.8e-05 24.8 0.1 0.076 13.2 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001281419.1_31325001_2 - 0.00062 19.7 0.0 0.015 15.4 0.0 2.6 3 0 0 3 3 3 1 Immunoglobulin domain Dynamin_M PF01031.18 001281635.1_31325001_2 - 2.3e-87 292.7 9.1 2.3e-87 292.7 9.1 1.9 2 1 1 3 3 3 1 Dynamin central region Dynamin_N PF00350.21 001281635.1_31325001_2 - 1.8e-49 167.9 3.0 3e-49 167.2 0.1 2.4 2 0 0 2 2 2 1 Dynamin family GED PF02212.16 001281635.1_31325001_2 - 3.5e-24 84.7 3.6 3.9e-24 84.5 1.8 2.1 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.21 001281635.1_31325001_2 - 0.00016 21.6 0.3 0.00082 19.3 0.3 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_21 PF13304.4 001281635.1_31325001_2 - 0.0034 17.1 0.1 0.022 14.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 001281635.1_31325001_2 - 0.028 14.0 0.1 0.059 13.0 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.25 001281635.1_31325001_2 - 0.051 13.9 1.3 0.34 11.3 0.0 2.5 2 0 0 2 2 2 0 ABC transporter AAA_16 PF13191.4 001281635.1_31325001_2 - 0.058 13.6 1.1 0.61 10.3 0.0 2.9 3 0 0 3 3 3 0 AAA ATPase domain UDPG_MGDP_dh_N PF03721.12 001281635.1_31325001_2 - 0.065 12.7 3.7 2.5 7.5 0.1 2.4 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AAA_28 PF13521.4 001281635.1_31325001_2 - 0.17 12.0 1.6 3.2 7.8 0.1 2.5 2 0 0 2 2 2 0 AAA domain Asp_protease_2 PF13650.4 001291224.1_31329001_1 - 0.0016 18.9 0.0 0.0026 18.3 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001291224.1_31329001_1 - 0.02 14.7 0.0 0.043 13.7 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001291224.1_31329001_1 - 0.037 14.5 0.0 0.06 13.8 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Retrotrans_gag PF03732.15 001291224.1_31329001_2 - 3.4e-16 59.2 0.0 6e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon gag protein DUF4939 PF16297.3 001291224.1_31329001_2 - 8.4e-15 54.5 0.0 1.1e-13 50.9 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4939) zf-CCHC_5 PF14787.4 001291224.1_31329001_2 - 0.0039 16.7 0.3 0.01 15.4 0.3 1.7 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger CAP_N PF01213.17 001291224.1_31329001_2 - 0.79 9.0 9.0 1.6 8.0 9.0 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal zf-CCHC PF00098.21 001291224.1_31329001_2 - 4.3 7.5 8.4 0.15 12.1 1.8 2.2 2 0 0 2 2 2 0 Zinc knuckle C1q PF00386.19 001281554.1_31322001_2 - 1.1e-40 138.6 1.6 1.4e-40 138.3 1.6 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.16 001281554.1_31322001_2 - 1.7e-10 40.3 29.0 4.9e-09 35.7 29.0 2.1 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) PAGK PF15284.4 001281554.1_31322001_2 - 0.13 12.1 0.1 0.24 11.2 0.1 1.4 1 0 0 1 1 1 0 Phage-encoded virulence factor Telomerase_RBD PF12009.6 001281627.1_31329001_1 - 4e-42 143.4 1.1 4e-42 143.4 1.1 1.8 2 0 0 2 2 2 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.25 001281627.1_31329001_1 - 1.7e-13 50.5 0.0 3.3e-10 39.7 0.0 2.4 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Nuc_sug_transp PF04142.13 001281371.1_31325001_1 - 1.9e-133 444.4 8.2 2.4e-133 444.1 8.2 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.18 001281371.1_31325001_1 - 4.1e-05 23.6 29.9 0.00035 20.6 7.6 2.5 2 1 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.3 001281371.1_31325001_1 - 0.012 14.7 5.8 0.019 14.0 5.8 1.4 1 1 0 1 1 1 0 Purine nucleobase transmembrane transport TPT PF03151.14 001281371.1_31325001_1 - 0.52 9.5 8.4 0.93 8.6 1.9 2.3 2 0 0 2 2 2 0 Triose-phosphate Transporter family UAA PF08449.9 001281371.1_31325001_1 - 1.9 7.5 13.0 1.4 7.9 4.8 2.6 1 1 1 2 2 2 0 UAA transporter family RNase_H PF00075.22 001285915.1_31322001_1 - 5.2e-45 153.0 0.0 7e-45 152.6 0.0 1.2 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.14 001285915.1_31322001_1 - 1.8e-18 66.4 0.5 3.3e-18 65.6 0.5 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin RVT_3 PF13456.4 001285915.1_31322001_1 - 0.0018 17.8 0.0 0.005 16.4 0.0 1.7 2 0 0 2 2 2 1 Reverse transcriptase-like DnaJ PF00226.29 001310578.1_31322001_1 - 1.4e-26 92.3 3.5 2.7e-26 91.3 3.5 1.5 1 0 0 1 1 1 1 DnaJ domain MTS_N PF08468.9 001310578.1_31322001_2 - 0.0082 16.1 0.8 0.013 15.4 0.1 1.6 2 0 0 2 2 2 1 Methyltransferase small domain N-terminal RHD_DNA_bind PF00554.20 001114281.1_49824001_1 - 1.4e-69 233.2 0.0 2e-69 232.8 0.0 1.2 1 0 0 1 1 1 1 Rel homology DNA-binding domain RHD_dimer PF16179.3 001114281.1_49824001_1 - 2.5e-37 126.9 0.0 4.6e-37 126.1 0.0 1.4 1 0 0 1 1 1 1 Rel homology dimerisation domain AAA_18 PF13238.4 001286114.1_31322001_1 - 1.3e-30 106.5 0.2 2e-30 105.8 0.0 1.4 2 0 0 2 2 1 1 AAA domain AAA_17 PF13207.4 001286114.1_31322001_1 - 1.6e-07 31.7 0.2 4.5e-07 30.2 0.1 1.8 1 1 1 2 2 2 1 AAA domain AAA_28 PF13521.4 001286114.1_31322001_1 - 3.8e-05 23.8 0.0 6.8e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA PF00004.27 001286114.1_31322001_1 - 6.3e-05 23.3 0.2 0.00022 21.5 0.1 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SKI PF01202.20 001286114.1_31322001_1 - 0.00017 21.6 2.6 0.024 14.6 0.0 2.9 2 1 1 3 3 3 1 Shikimate kinase AAA_16 PF13191.4 001286114.1_31322001_1 - 0.00036 20.8 0.6 0.0013 19.0 0.6 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.4 001286114.1_31322001_1 - 0.0024 17.9 0.4 0.017 15.2 0.4 2.3 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.4 001286114.1_31322001_1 - 0.0026 17.9 0.1 0.011 15.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain ADK PF00406.20 001286114.1_31322001_1 - 0.0036 17.3 0.1 0.036 14.0 0.0 2.1 2 0 0 2 2 2 1 Adenylate kinase NTPase_1 PF03266.13 001286114.1_31322001_1 - 0.0049 16.7 0.1 0.012 15.4 0.1 1.7 1 0 0 1 1 1 1 NTPase RuvB_N PF05496.10 001286114.1_31322001_1 - 0.005 16.0 0.1 0.0078 15.4 0.1 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.12 001286114.1_31322001_1 - 0.0067 16.3 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.20 001286114.1_31322001_1 - 0.023 14.9 0.0 0.04 14.2 0.0 1.4 1 0 0 1 1 1 0 RNA helicase Cytidylate_kin PF02224.16 001286114.1_31322001_1 - 0.023 14.3 0.0 0.034 13.7 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA_24 PF13479.4 001286114.1_31322001_1 - 0.027 14.1 0.1 0.064 12.8 0.1 1.6 1 0 0 1 1 1 0 AAA domain ATPase PF06745.11 001286114.1_31322001_1 - 0.032 13.4 1.6 0.1 11.8 0.2 2.0 2 0 0 2 2 2 0 KaiC TsaE PF02367.15 001286114.1_31322001_1 - 0.041 13.8 0.3 0.064 13.1 0.3 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE KTI12 PF08433.8 001286114.1_31322001_1 - 0.049 12.9 0.0 0.14 11.5 0.0 1.7 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_29 PF13555.4 001286114.1_31322001_1 - 0.062 12.9 0.4 0.11 12.1 0.4 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_3 PF07726.9 001286114.1_31322001_1 - 0.08 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) dNK PF01712.17 001286114.1_31322001_1 - 0.083 12.6 1.8 3.3 7.4 0.1 2.1 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_14 PF13173.4 001286114.1_31322001_1 - 0.12 12.3 0.1 0.34 10.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain NACHT PF05729.10 001286114.1_31322001_1 - 0.17 11.7 0.1 0.37 10.5 0.1 1.5 1 0 0 1 1 1 0 NACHT domain NCD2 PF04905.11 001281607.1_31325001_2 - 9e-65 217.3 0.9 9e-65 217.3 0.9 1.7 2 0 0 2 2 2 1 NAB conserved region 2 (NCD2) Nab1 PF04902.10 001281607.1_31325001_2 - 6e-53 179.8 1.0 9.6e-53 179.1 1.0 1.3 1 0 0 1 1 1 1 Conserved region in Nab1 NCD1 PF04904.11 001281607.1_31325001_2 - 3.7e-40 135.7 0.0 5.8e-40 135.0 0.0 1.3 1 0 0 1 1 1 1 NAB conserved region 1 (NCD1) Osteopontin PF00865.16 001281641.1_31323001_3 - 2.3e-119 398.1 59.2 2.8e-119 397.8 59.2 1.0 1 0 0 1 1 1 1 Osteopontin 7tm_1 PF00001.19 001287613.2_31323001_2 - 1.7e-49 168.3 31.7 2.5e-49 167.8 31.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001287613.2_31323001_2 - 0.0037 16.5 23.2 0.0037 16.5 23.2 2.2 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx MscS_TM PF12794.5 001287613.2_31323001_2 - 0.091 11.5 4.2 0.48 9.1 0.1 2.2 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 RA PF00788.21 001281619.1_31323001_1 - 6.6e-19 68.2 0.1 1.7e-18 66.9 0.1 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Nore1-SARAH PF16517.3 001281619.1_31323001_1 - 2.1e-18 65.8 4.7 3.8e-18 65.0 4.7 1.4 1 0 0 1 1 1 1 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain C1_1 PF00130.20 001281619.1_31323001_1 - 7.9e-08 31.9 14.0 1.4e-07 31.1 14.0 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Mst1_SARAH PF11629.6 001281619.1_31323001_1 - 0.012 15.5 0.9 0.028 14.4 0.9 1.5 1 0 0 1 1 1 0 C terminal SARAH domain of Mst1 zf-C2H2_10 PF16588.3 001281619.1_31323001_2 - 0.032 13.8 2.8 0.11 12.2 2.8 1.8 1 0 0 1 1 1 0 C2H2 zinc-finger Pkinase PF00069.23 001281584.1_31323001_1 - 1.9e-27 96.2 0.0 2.3e-27 95.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001281584.1_31323001_1 - 3.2e-17 62.5 0.0 4.1e-17 62.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 001281584.1_31323001_1 - 0.0005 19.9 0.0 0.0015 18.3 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.9 001281584.1_31323001_1 - 0.05 12.4 0.1 0.078 11.8 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.12 001281584.1_31323001_1 - 0.11 11.7 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Asp_protease_2 PF13650.4 001291223.1_31329001_1 - 0.0016 18.9 0.0 0.0026 18.3 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001291223.1_31329001_1 - 0.02 14.7 0.0 0.043 13.7 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001291223.1_31329001_1 - 0.037 14.5 0.0 0.06 13.8 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Retrotrans_gag PF03732.15 001291223.1_31329001_2 - 3.4e-16 59.2 0.0 6e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon gag protein DUF4939 PF16297.3 001291223.1_31329001_2 - 8.4e-15 54.5 0.0 1.1e-13 50.9 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4939) zf-CCHC_5 PF14787.4 001291223.1_31329001_2 - 0.0039 16.7 0.3 0.01 15.4 0.3 1.7 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger CAP_N PF01213.17 001291223.1_31329001_2 - 0.79 9.0 9.0 1.6 8.0 9.0 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal zf-CCHC PF00098.21 001291223.1_31329001_2 - 4.3 7.5 8.4 0.15 12.1 1.8 2.2 2 0 0 2 2 2 0 Zinc knuckle 7tm_1 PF00001.19 001281667.1_31324001_1 - 2.5e-74 249.7 13.9 3.2e-74 249.4 13.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001281667.1_31324001_1 - 4.5e-08 32.6 11.7 7.5e-08 31.9 11.7 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001281667.1_31324001_1 - 9.9e-05 22.1 4.9 9.9e-05 22.1 4.9 1.6 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001281667.1_31324001_1 - 0.0083 15.3 12.9 0.022 13.9 12.9 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Peptidase_M10 PF00413.22 001314269.1_09025001_1 - 4.5e-64 214.9 0.0 1.8e-63 213.0 0.0 1.9 1 1 0 1 1 1 1 Matrixin fn2 PF00040.17 001314269.1_09025001_1 - 5.9e-56 186.4 35.1 1.6e-19 69.7 6.6 3.7 3 0 0 3 3 3 3 Fibronectin type II domain Hemopexin PF00045.17 001314269.1_09025001_1 - 1.8e-21 75.6 7.9 4e-05 23.4 0.1 4.5 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.16 001314269.1_09025001_1 - 9.2e-11 41.7 0.1 1.9e-10 40.6 0.1 1.6 1 0 0 1 1 1 1 Putative peptidoglycan binding domain PT PF04886.10 001314269.1_09025001_1 - 1.5e-08 33.9 23.8 1.5e-08 33.9 23.8 2.7 1 1 1 2 2 2 1 PT repeat Astacin PF01400.22 001314269.1_09025001_1 - 0.045 13.2 0.1 3.4 7.1 0.0 2.2 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Reprolysin_4 PF13583.4 001314269.1_09025001_1 - 0.054 13.0 0.0 0.088 12.3 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.4 001314269.1_09025001_1 - 0.068 13.6 0.1 0.13 12.7 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.3 001314269.1_09025001_1 - 0.079 12.0 0.1 0.13 11.3 0.1 1.2 1 0 0 1 1 1 0 Met-zincin Ank_4 PF13637.4 001281539.1_31322001_1 - 3.8e-11 43.2 0.0 0.00052 20.4 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 001281539.1_31322001_1 - 3.8e-10 39.7 0.6 0.00024 21.2 0.3 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 001281539.1_31322001_1 - 1.4e-07 31.8 0.0 4.8e-07 30.2 0.0 1.8 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.28 001281539.1_31322001_1 - 6.9e-05 23.0 0.0 0.29 11.5 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.4 001281539.1_31322001_1 - 0.0018 18.5 0.0 0.75 10.4 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat zf-C4 PF00105.16 001281621.1_31326001_3 - 3.1e-32 110.7 16.2 3.1e-32 110.7 16.2 2.0 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001281621.1_31326001_3 - 9.8e-23 80.7 0.0 1.6e-22 80.0 0.0 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Lipocalin PF00061.21 001281651.1_31321001_2 - 1.2e-23 83.8 0.2 1.3e-23 83.6 0.2 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 001281651.1_31321001_2 - 1.8e-06 27.7 0.0 2.4e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family zf-C4 PF00105.16 001281573.1_31324001_3 - 2.1e-28 98.5 14.3 2.1e-28 98.5 14.3 1.9 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001281573.1_31324001_3 - 5.9e-24 84.7 1.8 9.2e-24 84.0 0.8 1.9 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor Fz PF01392.20 001281558.1_31322001_1 - 1.3e-28 99.8 3.1 3e-28 98.6 3.1 1.6 1 0 0 1 1 1 1 Fz domain NTR PF01759.19 001281558.1_31322001_1 - 2.2e-14 53.0 1.2 3.6e-14 52.3 1.2 1.3 1 0 0 1 1 1 1 UNC-6/NTR/C345C module DUF3371 PF11851.6 001281839.1_31323001_1 - 1.6e-35 122.7 0.8 1.6e-35 122.7 0.8 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3371) MITF_TFEB_C_3_N PF15951.3 001281839.1_31323001_1 - 4.2e-24 85.8 6.7 4.2e-24 85.8 6.7 2.5 2 1 0 2 2 2 1 MITF/TFEB/TFEC/TFE3 N-terminus HLH PF00010.24 001281839.1_31323001_1 - 4.8e-17 61.5 0.5 1.1e-16 60.3 0.5 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain TGF_beta PF00019.18 001281820.1_31323001_3 - 1.1e-14 55.0 0.1 3.4e-14 53.5 0.1 1.8 1 1 0 1 1 1 1 Transforming growth factor beta like domain zf-C4 PF00105.16 001281543.1_31323001_1 - 2.3e-28 98.3 16.1 4.8e-28 97.3 16.1 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001281543.1_31323001_1 - 1.8e-13 50.4 0.1 4.9e-13 49.0 0.1 1.7 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Tautomerase PF01361.19 001281543.1_31323001_1 - 0.16 11.8 0.0 0.37 10.6 0.0 1.6 1 0 0 1 1 1 0 Tautomerase enzyme Prokineticin PF06607.9 001281692.1_31323001_2 - 2.1e-46 156.1 6.4 3.8e-46 155.2 6.4 1.5 1 0 0 1 1 1 1 Prokineticin IL8 PF00048.18 001281344.1_31322001_3 - 1.3e-11 44.3 1.1 2.3e-11 43.6 1.1 1.4 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like ATP1G1_PLM_MAT8 PF02038.14 001287217.1_32923001_3 - 1.2e-17 62.8 0.1 2.2e-17 62.0 0.1 1.4 1 0 0 1 1 1 1 ATP1G1/PLM/MAT8 family Peptidase_C1 PF00112.21 001281687.1_31323001_1 - 2.4e-85 286.0 2.0 3.3e-85 285.5 2.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 001281687.1_31323001_1 - 4.9e-13 49.2 3.6 8.5e-13 48.4 3.6 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 001281687.1_31323001_1 - 0.0065 15.2 5.8 0.25 9.9 1.1 2.3 2 0 0 2 2 2 2 Peptidase C1-like family Aldo_ket_red PF00248.19 001281679.1_31323001_3 - 1.9e-57 194.5 0.0 2.7e-57 194.0 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family IL8 PF00048.18 001281341.1_31322001_3 - 1.1e-13 51.0 0.8 1.6e-13 50.4 0.8 1.3 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like IL8 PF00048.18 001281664.1_31321001_3 - 8.6e-18 64.1 1.0 1.1e-17 63.8 1.0 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like FA_desaturase PF00487.22 001281585.1_31323001_1 - 4.8e-15 56.0 16.1 4.8e-15 56.0 16.1 1.7 1 1 1 2 2 2 2 Fatty acid desaturase Connexin PF00029.17 001281580.1_31323001_1 - 1.9e-82 276.3 7.3 2.8e-82 275.7 7.3 1.3 1 0 0 1 1 1 1 Connexin STAT_bind PF02864.13 001281685.1_31325001_1 - 3.7e-80 269.3 0.2 3.7e-80 269.3 0.2 1.9 2 1 0 2 2 2 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 001281685.1_31325001_1 - 5.5e-55 185.9 17.6 5.5e-55 185.9 17.6 2.1 2 0 0 2 2 2 1 STAT protein, all-alpha domain STAT_int PF02865.15 001281685.1_31325001_1 - 1.2e-40 138.6 8.3 1.2e-40 138.6 8.3 3.2 3 0 0 3 3 3 1 STAT protein, protein interaction domain SH2 PF00017.22 001281685.1_31325001_1 - 1.8e-09 37.4 0.0 7.1e-09 35.5 0.0 2.1 1 0 0 1 1 1 1 SH2 domain TRPM_tetra PF16519.3 001281685.1_31325001_1 - 0.14 12.1 6.1 0.48 10.4 0.3 2.9 2 0 0 2 2 2 0 Tetramerisation domain of TRPM NPV_P10 PF05531.10 001281685.1_31325001_1 - 1.9 8.9 6.3 14 6.1 1.5 2.9 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Steroid_dh PF02544.14 001281617.1_31322001_3 - 2.6e-66 222.1 2.7 4e-66 221.5 2.7 1.3 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.10 001281617.1_31322001_3 - 5e-08 32.6 0.2 8.5e-08 31.9 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.11 001281617.1_31322001_3 - 0.027 14.7 0.3 0.083 13.2 0.3 1.9 1 1 0 1 1 1 0 Phospholipid methyltransferase Trypsin PF00089.24 001310566.1_31322001_3 - 1e-58 198.6 0.0 1.2e-58 198.4 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001310566.1_31322001_3 - 8.1e-06 26.6 0.0 1.7e-05 25.6 0.0 1.4 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S29 PF02907.13 001310566.1_31322001_3 - 0.061 12.9 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Mlh1_C PF16413.3 001281613.1_31325001_1 - 1.3e-95 319.7 0.0 2.2e-95 319.0 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.17 001281613.1_31325001_1 - 3.9e-34 116.7 0.1 6.8e-34 116.0 0.1 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.4 001281613.1_31325001_1 - 2.2e-14 53.3 0.0 4.2e-14 52.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.24 001281613.1_31325001_1 - 4.5e-07 30.3 0.5 1.7e-06 28.4 0.2 2.1 1 1 1 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GST_C PF00043.23 001281637.1_31322001_3 - 1e-19 70.4 0.0 1.6e-19 69.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.18 001281637.1_31322001_3 - 9e-19 67.5 0.0 4.5e-18 65.2 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.4 001281637.1_31322001_3 - 3.3e-18 65.6 0.0 5.3e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 001281637.1_31322001_3 - 0.035 14.4 0.0 0.084 13.1 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Homeobox PF00046.27 001281625.1_31324001_3 - 3.5e-23 81.1 6.3 5.5e-23 80.4 6.3 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001281625.1_31324001_3 - 0.0028 17.4 0.2 0.0054 16.5 0.2 1.5 1 0 0 1 1 1 1 Homeobox KN domain STAT_bind PF02864.13 001281622.1_31326001_1 - 7.2e-63 212.6 0.0 1.3e-62 211.8 0.0 1.4 1 0 0 1 1 1 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 001281622.1_31326001_1 - 2.1e-44 151.4 11.4 2.1e-44 151.4 11.4 1.9 2 0 0 2 2 2 1 STAT protein, all-alpha domain STAT_int PF02865.15 001281622.1_31326001_1 - 3.2e-29 101.7 3.2 3.2e-29 101.7 3.2 2.6 3 0 0 3 3 3 1 STAT protein, protein interaction domain STAT2_C PF12188.6 001281622.1_31326001_1 - 2.6e-26 91.2 7.6 3.1e-26 91.0 4.7 2.4 2 0 0 2 2 2 1 Signal transducer and activator of transcription 2 C terminal SH2 PF00017.22 001281622.1_31326001_1 - 6e-11 42.1 0.1 1.4e-10 40.9 0.1 1.6 1 0 0 1 1 1 1 SH2 domain 7tm_1 PF00001.19 001281690.1_31323001_3 - 2e-37 128.7 21.4 3.6e-37 127.9 21.4 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001281690.1_31323001_3 - 1.7e-05 24.5 15.1 0.00053 19.7 15.1 2.2 1 1 0 1 1 1 1 Olfactory receptor Connexin PF00029.17 001281593.1_31324001_3 - 4.8e-79 265.2 7.0 7.6e-79 264.5 7.0 1.3 1 0 0 1 1 1 1 Connexin Orthopox_A36R PF05950.9 001281593.1_31324001_3 - 0.16 12.0 0.3 0.25 11.3 0.3 1.2 1 0 0 1 1 1 0 Orthopoxvirus A36R protein Arginase PF00491.19 001281645.1_31322001_1 - 1.1e-77 261.2 0.0 1.3e-77 261.0 0.0 1.0 1 0 0 1 1 1 1 Arginase family wnt PF00110.17 001281324.1_31323001_1 - 1.8e-106 356.0 15.2 2.1e-106 355.8 15.2 1.0 1 0 0 1 1 1 1 wnt family NO_synthase PF02898.13 001281644.1_31329001_3 - 1.7e-185 616.2 0.0 2.3e-185 615.7 0.0 1.2 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain FAD_binding_1 PF00667.18 001281644.1_31329001_3 - 1.6e-77 259.9 0.0 3.4e-77 258.8 0.0 1.5 2 0 0 2 2 2 1 FAD binding domain Flavodoxin_1 PF00258.23 001281644.1_31329001_3 - 2.5e-39 134.6 0.3 4.8e-39 133.7 0.3 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.19 001281644.1_31329001_3 - 4.1e-23 82.0 0.0 8e-23 81.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.10 001281644.1_31329001_3 - 0.013 15.5 0.0 0.032 14.2 0.0 1.6 1 0 0 1 1 1 0 Ferric reductase NAD binding domain SGL PF08450.10 001281705.1_31323001_1 - 1.2e-77 260.7 0.1 1.4e-77 260.5 0.1 1.0 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region Reg_prop PF07494.9 001281705.1_31323001_1 - 0.023 14.7 0.0 0.14 12.3 0.0 2.3 2 0 0 2 2 2 0 Two component regulator propeller NHL PF01436.19 001281705.1_31323001_1 - 0.04 13.8 0.0 0.11 12.5 0.0 1.8 1 0 0 1 1 1 0 NHL repeat Ldh_2 PF02615.12 001281705.1_31323001_1 - 0.17 10.9 0.0 0.27 10.2 0.0 1.2 1 0 0 1 1 1 0 Malate/L-lactate dehydrogenase 7tm_1 PF00001.19 001281562.1_31323001_1 - 2.4e-48 164.6 25.5 4.7e-48 163.6 25.5 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001281562.1_31323001_1 - 4.7e-10 39.2 22.5 6e-10 38.8 22.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Pkinase PF00069.23 001281945.1_31325001_3 - 4.7e-54 183.4 0.2 1.1e-53 182.1 0.2 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001281945.1_31325001_3 - 3.8e-33 114.7 1.3 6.3e-33 114.0 0.0 2.0 2 1 0 2 2 2 1 Protein tyrosine kinase dsrm PF00035.24 001281945.1_31325001_3 - 7.6e-26 90.5 8.9 1.2e-13 51.3 0.0 3.5 3 0 0 3 3 3 2 Double-stranded RNA binding motif Kdo PF06293.12 001281945.1_31325001_3 - 0.0045 16.2 0.0 0.0098 15.1 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DND1_DSRM PF14709.5 001281945.1_31325001_3 - 0.0051 16.9 3.1 0.13 12.4 0.0 3.1 2 1 0 2 2 2 1 double strand RNA binding domain from DEAD END PROTEIN 1 Kinase-like PF14531.4 001281945.1_31325001_3 - 0.015 14.5 0.0 0.034 13.3 0.0 1.5 1 0 0 1 1 1 0 Kinase-like ABC1 PF03109.14 001281945.1_31325001_3 - 0.034 14.2 0.0 0.083 12.9 0.0 1.6 1 0 0 1 1 1 0 ABC1 family pKID PF02173.15 001281571.1_31322001_1 - 1.4e-21 75.5 2.5 2.8e-21 74.6 2.5 1.5 1 0 0 1 1 1 1 pKID domain HNF-1A_C PF04813.10 001281571.1_31322001_1 - 0.24 12.0 9.7 0.74 10.5 0.1 2.5 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus bZIP_1 PF00170.19 001281571.1_31322001_2 - 5.4e-09 35.9 3.0 5.4e-09 35.9 3.0 1.8 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.13 001281571.1_31322001_2 - 0.0032 17.4 1.8 0.0032 17.4 1.8 1.9 2 0 0 2 2 2 1 Basic region leucine zipper EF-hand_1 PF00036.30 001281347.1_31323001_2 - 2.2e-26 89.2 10.4 3.6e-07 29.1 0.7 5.2 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.4 001281347.1_31323001_2 - 5.9e-24 81.8 11.3 2.8e-07 29.8 0.6 5.5 5 0 0 5 5 5 4 EF-hand domain EF-hand_7 PF13499.4 001281347.1_31323001_2 - 5.6e-21 74.7 10.5 3.2e-09 37.0 3.0 3.3 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 001281347.1_31323001_2 - 1.4e-14 52.7 9.1 0.0038 16.6 0.0 5.0 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.4 001281347.1_31323001_2 - 5.2e-07 29.2 8.2 0.0015 18.2 0.6 3.9 4 0 0 4 4 4 2 EF-hand domain pair GPHH PF16905.3 001281347.1_31323001_2 - 0.0014 18.2 0.0 0.73 9.6 0.0 3.1 3 0 0 3 3 3 1 Voltage-dependent L-type calcium channel, IQ-associated SPARC_Ca_bdg PF10591.7 001281347.1_31323001_2 - 0.18 12.0 4.1 14 5.9 0.1 3.6 2 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.11 001281347.1_31323001_2 - 0.18 11.5 2.8 31 4.3 0.0 3.5 2 1 2 4 4 4 0 Caleosin related protein EF-hand_10 PF14788.4 001281347.1_31323001_2 - 1.6 8.5 8.8 4.8 7.0 0.2 3.9 3 1 1 4 4 4 0 EF hand Lipocalin PF00061.21 001310570.1_31322001_1 - 4.1e-12 46.4 0.1 7.7e-08 32.5 0.0 2.1 1 1 1 2 2 2 2 Lipocalin / cytosolic fatty-acid binding protein family IRF PF00605.15 001281646.1_31324001_3 - 3.7e-40 136.3 0.6 5.7e-40 135.7 0.6 1.3 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor Ig_4 PF16680.3 001281420.1_31322001_1 - 1e-24 86.5 1.0 1.5e-24 86.0 1.0 1.3 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 delta chain ITAM PF02189.13 001281420.1_31322001_1 - 2.1e-08 34.0 2.0 4.7e-08 32.9 2.0 1.6 1 0 0 1 1 1 1 Immunoreceptor tyrosine-based activation motif Ig_5 PF16681.3 001281420.1_31322001_1 - 6.6e-07 29.5 0.3 1.2e-06 28.7 0.3 1.5 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Tropomyosin PF00261.18 001281668.1_31322001_2 - 2.3e-86 288.9 81.3 3.3e-86 288.4 65.2 2.0 1 1 1 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.5 001281668.1_31322001_2 - 1.8e-36 125.2 79.6 1.4e-33 115.9 43.2 3.3 1 1 2 3 3 3 3 Tropomyosin like CLZ PF16526.3 001281668.1_31322001_2 - 3.8e-08 33.4 53.9 0.0002 21.5 6.6 4.9 2 2 3 5 5 5 4 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Laminin_II PF06009.10 001281668.1_31322001_2 - 0.0041 17.0 40.0 0.033 14.1 7.9 3.9 1 1 4 5 5 5 3 Laminin Domain II TTKRSYEDQ PF10212.7 001281668.1_31322001_2 - 0.0053 15.7 14.6 0.0053 15.7 14.6 2.2 1 1 1 2 2 2 1 Predicted coiled-coil domain-containing protein DUF3450 PF11932.6 001281668.1_31322001_2 - 0.0064 15.7 12.8 0.0064 15.7 12.8 3.8 1 1 3 4 4 4 1 Protein of unknown function (DUF3450) TMF_DNA_bd PF12329.6 001281668.1_31322001_2 - 0.0094 15.8 16.2 0.0094 15.8 16.2 6.1 1 1 4 6 6 5 2 TATA element modulatory factor 1 DNA binding BST2 PF16716.3 001281668.1_31322001_2 - 0.023 15.1 8.1 0.023 15.1 8.1 4.7 2 1 4 6 6 6 0 Bone marrow stromal antigen 2 SNARE PF05739.17 001281668.1_31322001_2 - 0.038 13.9 4.7 1.8 8.5 0.1 3.9 3 0 0 3 3 3 0 SNARE domain Reo_sigmaC PF04582.10 001281668.1_31322001_2 - 0.13 11.5 10.0 0.66 9.2 2.0 2.1 2 0 0 2 2 2 0 Reovirus sigma C capsid protein ADIP PF11559.6 001281668.1_31322001_2 - 0.13 12.2 56.1 0.092 12.7 6.6 4.2 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding DASH_Duo1 PF08651.8 001281668.1_31322001_2 - 0.34 10.6 11.1 0.17 11.5 0.4 3.8 3 1 1 4 4 4 0 DASH complex subunit Duo1 ERM PF00769.17 001281668.1_31322001_2 - 0.87 9.2 80.9 2.2 7.9 14.2 3.1 1 1 3 4 4 4 0 Ezrin/radixin/moesin family XhlA PF10779.7 001281668.1_31322001_2 - 0.95 9.6 52.3 0.49 10.5 4.8 6.4 3 2 5 8 8 8 0 Haemolysin XhlA HrpB7 PF09486.8 001281668.1_31322001_2 - 0.98 9.7 56.2 2.8 8.2 9.4 4.2 2 2 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) AAA_13 PF13166.4 001281668.1_31322001_2 - 1 7.8 50.5 5.1 5.5 30.3 2.5 1 1 2 3 3 3 0 AAA domain ATG16 PF08614.9 001281668.1_31322001_2 - 1 9.4 66.6 2 8.4 22.3 3.7 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Fib_alpha PF08702.8 001281668.1_31322001_2 - 2.7 8.0 31.5 0.071 13.2 7.7 3.1 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family MscS_porin PF12795.5 001281668.1_31322001_2 - 3.5 7.0 56.1 11 5.3 7.6 3.1 1 1 2 3 3 3 0 Mechanosensitive ion channel porin domain Spc7 PF08317.9 001281668.1_31322001_2 - 3.9 6.1 68.0 0.55 8.9 31.8 3.0 1 1 2 3 3 3 0 Spc7 kinetochore protein IncA PF04156.12 001281668.1_31322001_2 - 4 7.0 66.6 1.7 8.3 18.9 3.2 1 1 2 3 3 3 0 IncA protein Exonuc_VII_L PF02601.13 001281668.1_31322001_2 - 4.6 6.6 38.8 19 4.5 22.5 2.2 1 1 1 2 2 2 0 Exonuclease VII, large subunit Uds1 PF15456.4 001281668.1_31322001_2 - 5.4 7.1 47.7 2.4 8.2 17.3 3.7 1 1 2 3 3 3 0 Up-regulated During Septation Fmp27_WPPW PF10359.7 001281668.1_31322001_2 - 6 5.5 43.4 0.055 12.2 11.6 2.8 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain DUF724 PF05266.12 001281668.1_31322001_2 - 7.3 6.2 60.5 0.064 12.9 7.5 4.0 1 1 3 4 4 4 0 Protein of unknown function (DUF724) GAS PF13851.4 001281668.1_31322001_2 - 7.6 5.7 64.5 0.42 9.8 7.2 3.4 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Alanine_zipper PF11839.6 001281668.1_31322001_2 - 8 6.7 51.5 1.4 9.1 17.8 4.9 1 1 3 4 4 4 0 Alanine-zipper, major outer membrane lipoprotein Snapin_Pallidin PF14712.4 001281668.1_31322001_2 - 9.5 6.6 48.0 0.18 12.1 9.3 5.7 1 1 5 6 6 6 0 Snapin/Pallidin COesterase PF00135.26 001281669.1_31324001_2 - 5.7e-163 543.4 0.0 6.5e-163 543.2 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 001281669.1_31324001_2 - 1.4e-09 38.0 2.4 8.4e-09 35.4 2.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 001281669.1_31324001_2 - 0.00075 18.9 0.1 0.0014 18.0 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.18 001281669.1_31324001_2 - 0.0019 17.8 0.6 0.0066 16.0 0.6 1.8 1 1 0 1 1 1 1 Putative esterase Say1_Mug180 PF10340.7 001281669.1_31324001_2 - 0.1 11.3 0.0 0.32 9.7 0.0 1.6 1 1 0 1 1 1 0 Steryl acetyl hydrolase Sarcoglycan_1 PF04790.11 001281674.1_31322001_1 - 6.2e-63 212.4 0.1 7.6e-63 212.2 0.1 1.1 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein MH2 PF03166.12 001281698.1_31324001_3 - 2e-78 262.8 0.0 3e-78 262.1 0.0 1.3 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.14 001281698.1_31324001_3 - 9.4e-40 134.9 0.5 9.4e-40 134.9 0.5 1.7 2 0 0 2 2 2 1 MH1 domain IRF-3 PF10401.7 001281698.1_31324001_3 - 0.039 13.6 0.0 0.07 12.8 0.0 1.3 1 0 0 1 1 1 0 Interferon-regulatory factor 3 V-set PF07686.15 001310555.1_31326001_3 - 4.3e-06 26.7 1.3 1.8e-05 24.7 0.2 2.1 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001310555.1_31326001_3 - 0.001 19.5 0.5 0.84 10.2 0.2 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001310555.1_31326001_3 - 0.027 14.4 0.0 0.09 12.7 0.0 1.8 2 0 0 2 2 2 0 Immunoglobulin I-set domain V-set_CD47 PF08204.9 001310555.1_31326001_3 - 0.039 13.8 0.3 0.19 11.6 0.1 2.0 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain Topoisom_bac PF01131.18 001266407.2_29626001_1 - 3.8e-118 394.9 0.0 4.6e-118 394.7 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.20 001266407.2_29626001_1 - 5.3e-19 68.2 0.0 1.1e-18 67.2 0.0 1.6 1 0 0 1 1 1 1 Toprim domain FAT PF02259.21 001145455.1_39529001_1 - 5.6e-131 436.7 13.2 5.6e-131 436.7 13.2 2.3 3 0 0 3 3 3 1 FAT domain PI3_PI4_kinase PF00454.25 001145455.1_39529001_1 - 1.8e-76 257.1 0.1 3.7e-76 256.1 0.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.6 001145455.1_39529001_1 - 4.3e-60 202.1 5.2 7.2e-58 194.9 0.1 5.0 5 0 0 5 5 5 1 Domain of unknown function (DUF3385) FRB_dom PF08771.9 001145455.1_39529001_1 - 2.3e-46 156.1 0.4 2.3e-46 156.1 0.4 4.0 5 0 0 5 5 3 1 FKBP12-rapamycin binding domain FATC PF02260.18 001145455.1_39529001_1 - 4.2e-17 61.5 0.5 1.1e-16 60.2 0.5 1.8 1 0 0 1 1 1 1 FATC domain HEAT_2 PF13646.4 001145455.1_39529001_1 - 5.7e-09 36.1 11.3 0.18 12.1 0.0 8.5 10 0 0 10 10 9 3 HEAT repeats IFRD PF05004.11 001145455.1_39529001_1 - 3.5e-05 22.9 3.3 1.1 8.2 0.0 4.8 4 1 1 5 5 5 3 Interferon-related developmental regulator (IFRD) HEAT PF02985.20 001145455.1_39529001_1 - 0.00016 21.5 21.3 9 6.7 0.1 13.0 16 0 0 16 16 14 1 HEAT repeat V-ATPase_H_N PF03224.12 001145455.1_39529001_1 - 0.00081 18.6 0.2 0.67 9.1 0.1 3.5 3 0 0 3 3 3 2 V-ATPase subunit H UME PF08064.11 001145455.1_39529001_1 - 0.0017 18.1 6.8 0.57 10.0 0.3 5.7 5 0 0 5 5 5 1 UME (NUC010) domain TMEM154 PF15102.4 001145455.1_39529001_1 - 0.0074 16.1 2.3 0.018 14.8 2.3 1.6 1 0 0 1 1 1 1 TMEM154 protein family TPR_19 PF14559.4 001145455.1_39529001_1 - 0.017 15.5 0.7 2.6 8.5 0.0 3.7 4 0 0 4 4 2 0 Tetratricopeptide repeat EPSP_synthase PF00275.18 001145455.1_39529001_1 - 0.039 12.5 0.0 0.072 11.6 0.0 1.3 1 0 0 1 1 1 0 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) HEAT_EZ PF13513.4 001145455.1_39529001_1 - 0.048 14.0 33.0 0.093 13.1 0.0 12.9 16 0 0 16 16 15 0 HEAT-like repeat DUF1104 PF06518.9 001145455.1_39529001_1 - 0.44 10.8 5.3 4.2 7.7 0.6 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1104) ParcG PF10274.7 001145455.1_39529001_1 - 1.1 9.3 4.5 26 4.8 0.1 4.5 3 1 1 4 4 4 0 Parkin co-regulated protein Peptidase_M19 PF01244.19 001043356.1_22424001_1 - 7.3e-118 393.2 0.0 8.7e-118 393.0 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) DNA_topoisoIV PF00521.18 001265701.1_29629001_1 - 1.1e-133 446.1 0.3 2.4e-133 445.0 0.0 1.7 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.3 001265701.1_29629001_1 - 2.4e-49 166.7 4.5 2.4e-49 166.7 4.5 2.8 2 0 0 2 2 2 1 C-terminal associated domain of TOPRIM DTHCT PF08070.9 001265701.1_29629001_1 - 7e-29 100.5 13.7 7e-29 100.5 13.7 6.5 5 1 1 7 7 7 1 DTHCT (NUC029) region DNA_gyraseB PF00204.23 001265701.1_29629001_1 - 4.7e-27 94.4 0.6 1.1e-26 93.2 0.6 1.7 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.24 001265701.1_29629001_1 - 1.6e-14 54.3 0.1 6.1e-14 52.4 0.0 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.20 001265701.1_29629001_1 - 1e-09 38.4 0.0 4.1e-09 36.5 0.0 2.1 1 0 0 1 1 1 1 Toprim domain ODAM PF15424.4 001079916.1_39722001_2 - 6.8e-144 478.1 26.1 7.7e-144 478.0 26.1 1.0 1 0 0 1 1 1 1 Odontogenic ameloblast-associated family FAT PF02259.21 001285748.1_09029001_1 - 2.6e-130 434.5 14.0 2.6e-130 434.5 14.0 2.2 3 0 0 3 3 3 1 FAT domain PI3_PI4_kinase PF00454.25 001285748.1_09029001_1 - 2.2e-76 256.8 0.1 4.2e-76 255.9 0.1 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.6 001285748.1_09029001_1 - 7.3e-60 201.3 4.9 9.4e-58 194.5 0.1 4.8 5 0 0 5 5 5 1 Domain of unknown function (DUF3385) FRB_dom PF08771.9 001285748.1_09029001_1 - 2.6e-46 155.9 0.4 2.6e-46 155.9 0.4 4.0 5 0 0 5 5 3 1 FKBP12-rapamycin binding domain FATC PF02260.18 001285748.1_09029001_1 - 4.9e-16 58.1 0.5 1.3e-15 56.7 0.5 1.8 1 0 0 1 1 1 1 FATC domain HEAT_2 PF13646.4 001285748.1_09029001_1 - 4.6e-08 33.2 9.0 0.2 11.9 0.0 7.7 10 0 0 10 10 9 3 HEAT repeats Adaptin_N PF01602.18 001285748.1_09029001_1 - 6.4e-07 28.2 1.7 0.88 7.9 0.0 5.5 4 2 1 5 5 5 3 Adaptin N terminal region IFRD PF05004.11 001285748.1_09029001_1 - 5.9e-05 22.2 1.8 1.3 8.0 0.0 4.6 4 1 1 5 5 5 3 Interferon-related developmental regulator (IFRD) V-ATPase_H_N PF03224.12 001285748.1_09029001_1 - 0.0003 20.1 0.1 0.76 8.9 0.1 3.1 2 0 0 2 2 2 2 V-ATPase subunit H UME PF08064.11 001285748.1_09029001_1 - 0.0021 17.8 6.8 0.42 10.4 0.4 5.4 5 0 0 5 5 5 1 UME (NUC010) domain HEAT_EZ PF13513.4 001285748.1_09029001_1 - 0.0022 18.3 26.6 0.11 12.9 0.0 12.3 15 0 0 15 15 14 1 HEAT-like repeat HEAT PF02985.20 001285748.1_09029001_1 - 0.0075 16.3 20.9 10 6.6 0.1 12.1 16 0 0 16 16 15 1 HEAT repeat TPR_19 PF14559.4 001285748.1_09029001_1 - 0.014 15.8 0.1 2.9 8.3 0.0 3.6 3 0 0 3 3 2 0 Tetratricopeptide repeat TMEM154 PF15102.4 001285748.1_09029001_1 - 0.079 12.7 1.8 0.19 11.5 1.8 1.5 1 0 0 1 1 1 0 TMEM154 protein family Nucleoside_tran PF01733.16 125343.1_26225120_1 - 7.2e-70 235.7 7.0 9.4e-70 235.3 7.0 1.1 1 0 0 1 1 1 1 Nucleoside transporter Nucleoside_tran PF01733.16 125343.1_26225120_2 - 1.5e-42 145.9 0.0 2.2e-42 145.4 0.0 1.2 1 0 0 1 1 1 1 Nucleoside transporter DUF2070 PF09843.7 125343.1_26225120_2 - 0.88 7.7 12.7 1.2 7.2 12.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) FSAP_sig_propep PF03032.13 125343.1_26225120_3 - 9.5 6.2 5.7 0.86 9.5 0.6 1.8 2 0 0 2 2 2 0 Frog skin active peptide family signal and propeptide RRM_1 PF00076.20 136725.1_26226120_2 - 8.3e-20 70.3 0.0 1.2e-19 69.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 136725.1_26226120_2 - 0.035 13.6 0.0 0.057 12.9 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KRAB PF01352.25 147997.1_26227120_3 - 1.5e-23 82.1 0.2 2.6e-23 81.3 0.2 1.4 1 0 0 1 1 1 1 KRAB box Popeye PF04831.11 001194472.2_29624001_3 - 3.2e-48 163.3 1.5 4.3e-48 162.9 1.5 1.2 1 0 0 1 1 1 1 Popeye protein conserved region cNMP_binding PF00027.27 001194472.2_29624001_3 - 0.063 13.2 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain 7tm_1 PF00001.19 001198697.2_29627001_2 - 3.6e-69 232.9 15.8 7.1e-69 231.9 15.8 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001198697.2_29627001_2 - 1e-08 34.8 13.5 1.6e-08 34.1 13.5 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001198697.2_29627001_2 - 0.00061 19.5 12.4 0.0011 18.6 12.4 1.4 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001198697.2_29627001_2 - 0.04 13.1 13.4 0.03 13.5 11.6 1.6 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx Erg28 PF03694.11 001194135.2_29624001_2 - 4.4e-38 129.9 1.4 6.9e-38 129.3 1.4 1.3 1 0 0 1 1 1 1 Erg28 like protein Spb1_C PF07780.10 001266131.1_29626001_2 - 7.7e-71 237.9 14.1 7.7e-71 237.9 14.1 2.5 2 0 0 2 2 2 1 Spb1 C-terminal domain FtsJ PF01728.17 001266131.1_29626001_2 - 2.7e-56 190.3 0.0 5.8e-56 189.3 0.0 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.6 001266131.1_29626001_2 - 2.1e-45 154.3 13.0 2.1e-45 154.3 13.0 4.4 5 0 0 5 5 5 1 Domain of unknown function (DUF3381) M16C_assoc PF08367.9 001266131.1_29626001_2 - 0.026 13.5 5.6 0.056 12.4 5.6 1.5 1 0 0 1 1 1 0 Peptidase M16C associated DNA_primase_lrg PF04104.12 001266600.1_29624001_3 - 1.3e-94 316.4 0.1 2.9e-94 315.3 0.0 1.6 2 0 0 2 2 2 1 Eukaryotic and archaeal DNA primase, large subunit Transket_pyr PF02779.22 001244398.1_49824001_2 - 2.4e-46 157.5 0.0 4.2e-46 156.7 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.18 001244398.1_49824001_2 - 2.3e-38 130.7 0.1 6.6e-38 129.3 0.0 1.8 2 0 0 2 2 2 1 Transketolase, C-terminal domain SNF2_N PF00176.21 001123183.1_49826001_3 - 4.2e-57 193.3 0.0 6.3e-57 192.7 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.29 001123183.1_49826001_3 - 2.4e-15 56.7 0.0 4.9e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 001123183.1_49826001_3 - 1.7e-08 34.5 0.0 2.9e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.6 001123183.1_49826001_3 - 4.2e-07 29.3 0.0 1.2e-06 27.8 0.0 1.7 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Rad54_N PF08658.8 001123183.1_49826001_3 - 2.3e-06 27.8 0.1 2.6e-05 24.3 0.1 2.2 2 0 0 2 2 2 1 Rad54 N terminal Ras PF00071.20 001161856.1_39522001_2 - 8.9e-55 184.6 0.0 1.1e-54 184.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001161856.1_39522001_2 - 1.5e-22 79.9 0.0 2.1e-22 79.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001161856.1_39522001_2 - 8.8e-08 31.7 0.0 1.2e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family CagD PF16567.3 001161856.1_39522001_2 - 0.067 12.8 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Pathogenicity island component CagD Ras PF00071.20 001285656.1_09022001_1 - 7.4e-45 152.3 0.3 8.7e-45 152.1 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001285656.1_09022001_1 - 5.6e-16 58.7 0.1 1e-15 57.9 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001285656.1_09022001_1 - 2.9e-08 33.2 0.1 3.2e-08 33.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001285656.1_09022001_1 - 3.5e-05 23.7 0.1 7.3e-05 22.7 0.1 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001285656.1_09022001_1 - 0.0001 21.8 0.3 0.00063 19.2 0.2 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001285656.1_09022001_1 - 0.00097 18.9 0.3 0.05 13.4 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF258 SRPRB PF09439.8 001285656.1_09022001_1 - 0.00099 18.4 0.1 0.0018 17.6 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_14 PF13173.4 001285656.1_09022001_1 - 0.078 12.9 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Pam16 PF03656.11 001347981.1_39722001_1 - 9.3e-62 206.5 2.3 1.1e-61 206.3 2.3 1.0 1 0 0 1 1 1 1 Pam16 Integrase_Zn PF02022.17 001347981.1_39722001_1 - 0.19 11.6 2.0 4 7.3 0.9 2.3 2 0 0 2 2 2 0 Integrase Zinc binding domain DNA_primase_S PF01896.17 001243669.1_49823001_3 - 4.8e-57 192.9 0.8 6.8e-57 192.4 0.8 1.2 1 0 0 1 1 1 1 DNA primase small subunit Ras PF00071.20 001161866.1_39522001_1 - 6.5e-47 159.0 0.5 7.6e-47 158.8 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001161866.1_39522001_1 - 5e-17 62.1 0.1 9.2e-17 61.3 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001161866.1_39522001_1 - 4.7e-08 32.6 0.1 4.9e-08 32.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001161866.1_39522001_1 - 2.8e-05 24.0 0.1 5.4e-05 23.1 0.1 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001161866.1_39522001_1 - 4.9e-05 22.8 0.2 0.0002 20.8 0.2 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001161866.1_39522001_1 - 0.00018 21.3 0.3 0.0081 15.9 0.2 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF258 SRPRB PF09439.8 001161866.1_39522001_1 - 0.00056 19.3 0.1 0.00095 18.5 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.20 001243585.1_49823001_3 - 1.2e-54 184.1 0.0 1.5e-54 183.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001243585.1_49823001_3 - 2e-22 79.5 0.0 2.7e-22 79.1 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001243585.1_49823001_3 - 1.2e-07 31.2 0.0 1.6e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family CagD PF16567.3 001243585.1_49823001_3 - 0.082 12.6 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 Pathogenicity island component CagD Ras PF00071.20 001261377.1_29624001_2 - 5.1e-53 178.8 0.0 6.6e-53 178.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001261377.1_29624001_2 - 2e-21 76.3 0.0 2.8e-21 75.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001261377.1_29624001_2 - 1.9e-06 27.3 0.0 3.2e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.20 001287846.1_49822001_1 - 6.5e-47 159.0 0.5 7.6e-47 158.8 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001287846.1_49822001_1 - 5e-17 62.1 0.1 9.2e-17 61.3 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001287846.1_49822001_1 - 4.7e-08 32.6 0.1 4.9e-08 32.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001287846.1_49822001_1 - 2.8e-05 24.0 0.1 5.4e-05 23.1 0.1 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001287846.1_49822001_1 - 4.9e-05 22.8 0.2 0.0002 20.8 0.2 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001287846.1_49822001_1 - 0.00018 21.3 0.3 0.0081 15.9 0.2 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF258 SRPRB PF09439.8 001287846.1_49822001_1 - 0.00056 19.3 0.1 0.00095 18.5 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RIIa PF02197.15 001194626.2_29625001_2 - 0.0015 18.0 0.1 0.0036 16.8 0.1 1.7 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit adh_short PF00106.23 001329081.1_37922001_1 - 3.5e-27 95.0 0.0 4.4e-27 94.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001329081.1_37922001_1 - 4e-16 59.2 0.0 5e-16 58.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001329081.1_37922001_1 - 0.0016 18.2 0.1 0.0088 15.8 0.0 2.2 2 1 0 2 2 2 1 KR domain MH2 PF03166.12 001256148.1_49823001_2 - 9.1e-80 267.1 0.1 1.3e-79 266.6 0.1 1.2 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.14 001256148.1_49823001_2 - 4.8e-45 151.9 4.4 9.1e-45 151.0 4.4 1.5 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.7 001256148.1_49823001_2 - 0.0039 16.9 0.0 0.0059 16.3 0.0 1.3 1 0 0 1 1 1 1 Interferon-regulatory factor 3 Homeobox PF00046.27 001129971.1_49823001_2 - 2.9e-18 65.3 5.7 6.8e-18 64.1 5.7 1.7 1 0 0 1 1 1 1 Homeobox domain PMP22_Claudin PF00822.18 001244539.1_49823001_3 - 7.4e-52 175.4 10.3 9.2e-52 175.1 10.3 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001244539.1_49823001_3 - 1.3e-10 41.3 9.5 1.4e-09 37.8 9.5 2.1 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction SUR7 PF06687.10 001244539.1_49823001_3 - 0.015 14.8 6.9 0.018 14.5 4.2 2.0 1 1 1 2 2 2 0 SUR7/PalI family CD20 PF04103.13 001244539.1_49823001_3 - 0.022 14.7 2.1 0.022 14.7 2.1 2.7 2 1 1 3 3 3 0 CD20-like family DUF4134 PF13572.4 001244539.1_49823001_3 - 0.081 13.1 2.4 0.19 11.9 2.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4134) DUF898 PF05987.11 001244539.1_49823001_3 - 0.37 9.7 5.5 0.084 11.8 1.6 1.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF898) LRR_8 PF13855.4 001130466.2_39723001_3 - 2.4e-08 33.5 0.3 0.00094 18.8 0.0 4.0 4 0 0 4 4 4 2 Leucine rich repeat LRR_4 PF12799.5 001130466.2_39723001_3 - 3.7e-08 33.4 3.1 0.01 16.1 0.0 4.4 4 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001130466.2_39723001_3 - 0.00012 21.9 5.0 6.5 7.5 0.0 5.0 5 1 0 5 5 5 2 Leucine Rich Repeat LRR_6 PF13516.4 001130466.2_39723001_3 - 0.00019 21.1 7.9 0.9 9.6 0.0 5.1 5 0 0 5 5 5 2 Leucine Rich repeat PMP22_Claudin PF00822.18 001161637.1_49823001_1 - 6.5e-34 117.1 11.1 8.1e-34 116.8 11.1 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001161637.1_49823001_1 - 1.8e-08 34.3 13.7 1.3e-07 31.4 13.7 2.0 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF4131 PF13567.4 001161637.1_49823001_1 - 0.029 13.9 0.2 0.029 13.9 0.2 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) TMEM37 PF15108.4 001161637.1_49823001_1 - 0.04 13.7 4.9 0.062 13.0 4.9 1.3 1 0 0 1 1 1 0 Voltage-dependent calcium channel gamma-like subunit protein family DUF4064 PF13273.4 001161637.1_49823001_1 - 0.36 11.1 10.4 0.46 10.7 7.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) eIF-6 PF01912.16 052024.1_26222120_2 - 6.5e-32 110.4 0.4 2.4e-31 108.5 0.1 1.8 2 0 0 2 2 2 1 eIF-6 family eIF-6 PF01912.16 052024.1_26222120_3 - 0.00051 19.3 0.0 0.00065 19.0 0.0 1.1 1 0 0 1 1 1 1 eIF-6 family AJAP1_PANP_C PF15298.4 001194405.2_29625001_2 - 1.1e-07 32.1 0.0 2.8e-07 30.8 0.0 1.5 2 0 0 2 2 2 1 AJAP1/PANP C-terminus RabGAP-TBC PF00566.16 001194740.2_29625001_3 - 4.6e-35 121.1 6.3 1.2e-32 113.2 3.8 2.4 2 1 0 2 2 2 2 Rab-GTPase-TBC domain TFIID_20kDa PF03847.11 001194740.2_29625001_3 - 0.082 13.3 0.3 0.19 12.1 0.1 1.7 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A Rhomboid PF01694.20 001194571.2_29623001_1 - 4.4e-34 117.5 10.8 4.4e-34 117.5 10.8 1.6 2 0 0 2 2 2 1 Rhomboid family EF-hand_7 PF13499.4 001194571.2_29623001_1 - 3.3e-05 24.2 0.0 5.5e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 001194571.2_29623001_1 - 0.0002 20.5 0.0 0.34 10.4 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 001194571.2_29623001_1 - 0.0003 20.4 0.0 0.12 12.3 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.4 001194571.2_29623001_1 - 0.04 13.6 0.0 0.079 12.6 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_11 PF08976.9 001194571.2_29623001_1 - 0.067 13.9 0.0 0.11 13.2 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain DUF3087 PF11286.6 001194571.2_29623001_1 - 0.092 12.1 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3087) DUF4203 PF13886.4 001194571.2_29623001_1 - 9.5 5.7 17.0 6.6 6.2 2.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4203) Humanin PF15040.4 001195073.2_29623001_1 - 3.9e-15 54.9 0.0 6.2e-15 54.3 0.0 1.3 1 0 0 1 1 1 1 Humanin family eIF-1a PF01176.17 001354576.1_32922001_3 - 6e-17 61.1 0.0 8.7e-17 60.6 0.0 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 PAP2 PF01569.19 148893.1_26225120_2 - 8.9e-25 86.9 1.1 1.7e-24 86.0 1.1 1.4 1 0 0 1 1 1 1 PAP2 superfamily Peptidase_C48 PF02902.17 001205128.2_39725001_2 - 3.9e-46 157.5 3.1 6e-46 156.9 3.1 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Nop53 PF07767.9 001205128.2_39725001_2 - 0.23 10.7 6.8 0.026 13.8 2.4 1.5 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) DUF3318 PF11780.6 001205128.2_39725001_3 - 0.11 12.3 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3318) Ysc84 PF04366.10 001251864.2_39724001_1 - 4.3e-40 136.3 0.0 6.3e-40 135.8 0.0 1.2 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.26 001251864.2_39724001_1 - 2.6e-15 55.6 0.0 5.1e-15 54.7 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 001251864.2_39724001_1 - 8.1e-15 54.3 0.0 1.4e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001251864.2_39724001_1 - 9.3e-11 41.1 0.0 1.7e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain MARVEL PF01284.21 001137663.2_39722001_2 - 1.2e-29 103.1 5.8 1.4e-29 102.8 5.8 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF805 PF05656.12 001137663.2_39722001_2 - 0.015 15.6 1.5 0.082 13.2 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF805) DUF4064 PF13273.4 001137663.2_39722001_2 - 0.016 15.4 0.0 3.6 7.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) Col_cuticle_N PF01484.15 001137663.2_39722001_2 - 4.6 7.3 7.8 11 6.1 0.1 3.2 3 0 0 3 3 3 0 Nematode cuticle collagen N-terminal domain MAGE PF01454.17 001024893.1_45724001_3 - 1.5e-13 50.8 0.0 3e-08 33.5 0.0 2.2 2 0 0 2 2 2 2 MAGE family MAGE_N PF12440.6 001024893.1_45724001_3 - 0.00034 21.1 1.5 0.00064 20.2 1.5 1.3 1 0 0 1 1 1 1 Melanoma associated antigen family N terminal Clat_adaptor_s PF01217.18 001252535.2_39725001_2 - 4.9e-59 198.2 1.9 4.9e-59 198.2 1.9 1.5 2 0 0 2 2 2 1 Clathrin adaptor complex small chain SRTM1 PF15872.3 001354500.1_49829001_1 - 1.4e-11 44.3 0.3 2.7e-11 43.4 0.3 1.4 1 0 0 1 1 1 1 Serine-rich and transmembrane domain-containing protein 1 TNF PF00229.16 001246420.1_39724001_3 - 4.6e-45 152.5 0.9 1.2e-44 151.2 0.9 1.7 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1q PF00386.19 001246420.1_39724001_3 - 0.04 14.0 3.3 1.5 8.9 0.0 2.6 1 1 1 2 2 2 0 C1q domain TNF PF00229.16 001205130.1_39725001_2 - 1.1e-11 44.7 0.0 1.8e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family DUF1049 PF06305.9 001205130.1_39725001_2 - 0.039 13.7 1.0 0.078 12.7 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) MFAP1 PF06991.9 001246371.1_39725001_1 - 7.2e-78 261.2 30.1 7.2e-78 261.2 30.1 2.2 2 0 0 2 2 2 1 Microfibril-associated/Pre-mRNA processing TNF PF00229.16 001205129.1_39723001_1 - 6.2e-16 58.4 0.0 8.7e-16 57.9 0.0 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1q PF00386.19 001205129.1_39723001_1 - 0.014 15.5 0.0 0.021 14.9 0.0 1.2 1 0 0 1 1 1 0 C1q domain RskA PF10099.7 001205129.1_39723001_1 - 1.1 9.4 9.5 2.3 8.3 9.5 1.6 1 1 0 1 1 1 0 Anti-sigma-K factor rskA CEP63 PF17045.3 001280232.1_39725001_2 - 4.5e-95 318.5 37.8 4.5e-95 318.5 37.8 3.5 4 0 0 4 4 4 2 Centrosomal protein of 63 kDa Tup_N PF08581.8 001280232.1_39725001_2 - 0.012 15.7 0.3 0.012 15.7 0.3 7.4 5 2 2 7 7 7 0 Tup N-terminal COX17 PF05051.11 001252540.1_39721001_2 - 4.1e-21 74.9 6.8 6e-21 74.4 6.8 1.2 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) Methyltransf_23 PF13489.4 001280301.1_39724001_1 - 2.8e-06 27.2 0.0 5.3e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 001280301.1_39724001_1 - 0.00092 18.9 0.0 0.0083 15.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001280301.1_39724001_1 - 0.0028 18.2 0.0 0.007 16.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.10 001280301.1_39724001_1 - 0.015 14.8 0.1 0.025 14.1 0.1 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_25 PF13649.4 001280301.1_39724001_1 - 0.017 15.7 0.0 0.048 14.3 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain RLL PF10036.7 001266427.1_29622001_2 - 1.5e-90 303.4 1.1 1.7e-90 303.3 1.1 1.0 1 0 0 1 1 1 1 Putative carnitine deficiency-associated protein Cactin_mid PF10312.7 001266427.1_29622001_2 - 0.0065 16.1 0.5 0.0098 15.5 0.5 1.2 1 0 0 1 1 1 1 Conserved mid region of cactin Histone PF00125.22 001280448.1_39724001_2 - 3e-53 179.6 1.7 3.8e-53 179.3 1.7 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.4 001280448.1_39724001_2 - 0.0007 19.5 0.0 0.0012 18.8 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.4 001280448.1_39724001_2 - 0.003 17.8 0.0 0.0049 17.1 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.3 001280448.1_39724001_2 - 0.12 12.9 2.9 0.19 12.2 2.9 1.3 1 0 0 1 1 1 0 PCNA-associated factor CWC25 PF12542.6 001246613.1_39725001_1 - 3.1e-20 72.7 0.0 3.1e-20 72.7 0.0 3.5 4 0 0 4 4 4 1 Pre-mRNA splicing factor Cir_N PF10197.7 001246613.1_39725001_1 - 2.8e-15 56.1 13.4 2.8e-15 56.1 13.4 5.6 5 1 0 5 5 5 1 N-terminal domain of CBF1 interacting co-repressor CIR TNF PF00229.16 001328319.1_39722001_1 - 2.4e-10 40.3 0.0 3.8e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family TNF PF00229.16 001328320.1_39722001_1 - 1.9e-30 105.3 0.0 2.6e-30 104.9 0.0 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family TNF PF00229.16 001328321.1_39722001_1 - 9.6e-40 135.3 0.0 1.7e-39 134.5 0.0 1.4 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family SH2 PF00017.22 111904.1_26224120_1 - 1.2e-09 37.9 0.0 2.1e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 SH2 domain Aha1_N PF09229.9 001107241.1_45728001_1 - 1.1e-31 109.8 0.6 1.5e-31 109.3 0.6 1.2 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.9 001107241.1_45728001_2 - 7.3e-19 68.1 0.1 1.1e-18 67.5 0.1 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein IF4E PF01652.16 001347083.1_32927001_3 - 4.3e-59 198.7 0.1 6.2e-59 198.2 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E GAIN PF16489.3 110533.1_26223120_2 - 2.8e-11 43.1 0.0 3.8e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain SLC3A2_N PF16028.3 001354865.1_29525001_1 - 4e-32 109.4 1.4 7.5e-32 108.6 1.4 1.4 1 0 0 1 1 1 1 Solute carrier family 3 member 2 N-terminus Alpha-amylase PF00128.22 001354865.1_29525001_1 - 8.9e-22 78.0 0.1 2.1e-14 53.7 0.0 3.1 1 1 1 2 2 2 2 Alpha amylase, catalytic domain DUF3459 PF11941.6 001354865.1_29525001_1 - 0.001 19.2 0.1 0.0029 17.8 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3459) TrkH PF02386.14 001354865.1_29525001_1 - 0.15 10.4 0.0 0.36 9.1 0.0 1.5 2 0 0 2 2 2 0 Cation transport protein Cellulase PF00150.16 001354865.1_29525001_1 - 0.28 10.4 0.5 0.52 9.6 0.0 1.6 2 0 0 2 2 2 0 Cellulase (glycosyl hydrolase family 5) SLC3A2_N PF16028.3 001285242.2_29524001_2 - 3.8e-32 109.5 1.4 7e-32 108.7 1.4 1.4 1 0 0 1 1 1 1 Solute carrier family 3 member 2 N-terminus Alpha-amylase PF00128.22 001285242.2_29524001_2 - 7.6e-22 78.2 0.1 2e-14 53.8 0.0 3.1 1 1 1 2 2 2 2 Alpha amylase, catalytic domain DUF3459 PF11941.6 001285242.2_29524001_2 - 0.0012 19.0 0.1 0.0027 17.8 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3459) TrkH PF02386.14 001285242.2_29524001_2 - 0.14 10.5 0.0 0.34 9.2 0.0 1.5 2 0 0 2 2 2 0 Cation transport protein Cellulase PF00150.16 001285242.2_29524001_2 - 0.26 10.6 0.5 0.48 9.7 0.0 1.6 2 0 0 2 2 2 0 Cellulase (glycosyl hydrolase family 5) AIRS_C PF02769.20 001159420.1_29625001_3 - 2.2e-27 95.9 0.1 3.5e-27 95.3 0.1 1.3 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.22 001159420.1_29625001_3 - 6.8e-10 39.3 0.3 2.7e-09 37.4 0.1 2.0 1 1 1 2 2 2 1 AIR synthase related protein, N-terminal domain 7tm_1 PF00001.19 214229.1_49823001_1 - 7.8e-36 123.6 9.7 1.5e-35 122.6 9.7 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 214229.1_49823001_1 - 0.00013 21.3 12.4 0.0035 16.6 0.2 3.0 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx DUF4149 PF13664.4 214229.1_49823001_1 - 2 8.6 6.0 2 8.6 0.7 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4149) Cathelicidins PF00666.15 001009301.1_39522001_1 - 2.7e-47 159.1 0.5 3.4e-47 158.8 0.5 1.1 1 0 0 1 1 1 1 Cathelicidin Spp-24 PF07448.9 001009301.1_39522001_1 - 3e-05 24.0 0.2 4.6e-05 23.4 0.2 1.2 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Trypan_PARP PF05887.9 001009301.1_39522001_1 - 0.26 11.2 3.6 0.076 12.9 0.6 1.7 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Acetyltransf_1 PF00583.23 001012440.1_39722001_1 - 2.2e-10 40.7 0.0 2.8e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.5 001012440.1_39722001_1 - 6.6e-06 25.9 0.0 8e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.5 001012440.1_39722001_1 - 0.0062 16.8 0.0 0.0098 16.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain 7tm_1 PF00001.19 001009433.1_39523001_1 - 8.8e-35 120.1 11.2 1.5e-34 119.4 11.2 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001009433.1_39523001_1 - 4.1e-05 23.0 11.9 0.0035 16.6 11.6 3.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF4149 PF13664.4 001009433.1_39523001_1 - 7.5 6.8 7.0 4 7.7 0.2 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4149) Glycogen_syn PF05693.11 001032886.1_29625001_1 - 0 1209.6 0.0 0 1209.3 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glyco_transf_4 PF13439.4 001032886.1_29625001_1 - 3.9e-07 30.1 0.1 7e-07 29.3 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_transf_5 PF08323.9 001032886.1_29625001_1 - 6.1e-06 26.0 0.4 1.6e-05 24.6 0.4 1.8 1 1 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.18 001032886.1_29625001_1 - 8e-06 25.4 0.1 0.00062 19.2 0.0 2.5 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.4 001032886.1_29625001_1 - 1.8e-05 25.1 0.2 4.5e-05 23.8 0.2 1.7 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.4 001032886.1_29625001_1 - 7.9e-05 23.0 0.0 0.011 16.0 0.0 2.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 Arm PF00514.21 214367.1_49827001_3 - 1.3e-41 139.2 19.2 1.2e-07 31.3 0.1 12.0 13 0 0 13 13 13 7 Armadillo/beta-catenin-like repeat Cnd1 PF12717.5 214367.1_49827001_3 - 1.1e-08 35.2 1.7 0.0049 16.7 0.3 4.4 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.4 214367.1_49827001_3 - 2.9e-06 27.5 6.4 1.5 9.2 0.0 6.2 5 1 1 6 6 6 2 HEAT-like repeat Adaptin_N PF01602.18 214367.1_49827001_3 - 6.3e-06 24.9 2.6 0.0013 17.3 1.1 3.1 3 0 0 3 3 3 2 Adaptin N terminal region HEAT PF02985.20 214367.1_49827001_3 - 6.4e-06 25.8 1.5 22 5.5 0.0 5.7 5 0 0 5 5 5 0 HEAT repeat HEAT_2 PF13646.4 214367.1_49827001_3 - 7.9e-06 26.0 6.3 0.042 14.1 0.4 4.9 4 1 1 5 5 5 1 HEAT repeats Atx10homo_assoc PF09759.7 214367.1_49827001_3 - 0.0014 18.5 1.0 0.016 15.2 0.2 3.1 3 1 1 4 4 4 1 Spinocerebellar ataxia type 10 protein domain DUF3361 PF11841.6 214367.1_49827001_3 - 0.0022 17.8 1.9 2.5 7.9 0.0 4.4 2 1 1 4 4 4 1 Domain of unknown function (DUF3361) RasGEF_N_2 PF14663.4 214367.1_49827001_3 - 0.0026 18.0 4.0 7.2 6.9 0.0 4.7 4 1 1 5 5 5 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain Queuosine_synth PF02547.13 214367.1_49827001_3 - 0.026 13.5 0.4 0.05 12.6 0.1 1.5 2 0 0 2 2 2 0 Queuosine biosynthesis protein Arm_2 PF04826.11 214367.1_49827001_3 - 0.04 13.3 3.7 0.92 8.8 0.0 3.4 2 1 1 3 3 3 0 Armadillo-like BIR PF00653.19 001009280.1_22422001_1 - 1.5e-23 83.1 2.3 1.5e-23 83.1 2.3 1.5 2 0 0 2 2 2 1 Inhibitor of Apoptosis domain Cathelicidins PF00666.15 001009406.1_39522001_1 - 7.4e-51 170.5 0.5 9.4e-51 170.2 0.5 1.1 1 0 0 1 1 1 1 Cathelicidin Cystatin PF00031.19 001009406.1_39522001_1 - 0.00024 21.2 0.4 0.00073 19.6 0.4 1.7 1 1 0 1 1 1 1 Cystatin domain Spp-24 PF07448.9 001009406.1_39522001_1 - 0.00037 20.5 0.1 0.00061 19.8 0.1 1.3 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain BIR PF00653.19 001009036.1_39722001_1 - 2.7e-18 66.3 0.3 2.7e-18 66.3 0.3 2.6 3 1 0 3 3 3 1 Inhibitor of Apoptosis domain zf-C3HC4_3 PF13920.4 001009036.1_39722001_1 - 2.8e-13 49.3 8.9 2.8e-13 49.3 8.9 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 001009036.1_39722001_1 - 3.5e-06 26.6 9.2 7.2e-06 25.6 9.2 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.4 001009036.1_39722001_1 - 0.0051 16.5 11.7 0.0051 16.5 11.7 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001009036.1_39722001_1 - 0.018 14.9 9.2 0.018 14.9 9.2 2.0 2 0 0 2 2 2 0 zinc-RING finger domain DUF2039 PF10217.7 001009036.1_39722001_1 - 1.4 9.2 7.7 0.34 11.1 4.3 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) DZR PF12773.5 001009036.1_39722001_1 - 4 7.4 10.6 29 4.7 7.2 3.0 2 1 0 2 2 2 0 Double zinc ribbon DNA_RNApol_7kD PF03604.11 001009036.1_39722001_1 - 5.3 6.7 10.4 3.6 7.2 0.0 3.5 3 1 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit 7tm_1 PF00001.19 001040286.1_39523001_1 - 3.2e-45 154.3 36.5 6.4e-45 153.3 36.5 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001040286.1_39523001_1 - 2.6e-07 30.2 24.2 2.6e-07 30.2 24.2 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF621 PF04789.13 001040286.1_39523001_1 - 0.0029 16.7 23.3 0.0039 16.3 23.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF621) 7tm_1 PF00001.19 001009826.1_22424001_1 - 1.5e-50 171.8 15.5 3.8e-50 170.5 15.5 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CXCR4_N PF12109.6 001009826.1_22424001_1 - 4.1e-15 55.6 2.4 6.2e-15 55.0 2.4 1.3 1 0 0 1 1 1 1 CXCR4 Chemokine receptor N terminal 7TM_GPCR_Srsx PF10320.7 001009826.1_22424001_1 - 0.0001 21.7 13.4 0.00016 21.0 13.4 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF4538 PF15061.4 001009826.1_22424001_1 - 0.17 11.5 0.1 0.49 10.0 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4538) EF-hand_7 PF13499.4 001114765.1_39522001_1 - 3.3e-11 43.3 6.0 3.4e-10 40.1 1.7 2.6 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.30 001114765.1_39522001_1 - 1.9e-10 39.4 5.1 8.8e-05 21.7 0.1 3.5 3 1 0 3 3 3 2 EF hand EF-hand_6 PF13405.4 001114765.1_39522001_1 - 1e-08 34.3 3.6 0.00052 19.6 0.2 3.9 4 1 1 5 5 5 2 EF-hand domain EF-hand_8 PF13833.4 001114765.1_39522001_1 - 9.1e-08 31.6 3.9 0.0022 17.6 0.6 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.4 001114765.1_39522001_1 - 1.1e-06 27.7 3.2 0.027 13.9 0.3 3.1 2 1 1 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.7 001114765.1_39522001_1 - 0.023 14.9 0.3 0.23 11.7 0.3 2.1 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 001114765.1_39522001_1 - 0.056 13.3 1.5 0.22 11.3 0.2 2.2 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Glyco_hydro_15 PF00723.19 001135681.1_37929001_3 - 1.7e-199 663.1 0.0 2e-199 662.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 LRS4 PF10422.7 001135681.1_37929001_3 - 0.25 10.7 1.3 0.61 9.5 1.3 1.5 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 TGFb_propeptide PF00688.16 001082650.1_37925001_1 - 1.6e-50 172.0 0.1 2.5e-50 171.4 0.1 1.3 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001082650.1_37925001_1 - 2.2e-34 118.3 0.7 4.4e-34 117.4 0.7 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain 7tm_1 PF00001.19 001112630.1_40423001_1 - 2.9e-51 174.1 16.6 6.5e-51 173.0 16.6 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CXCR4_N PF12109.6 001112630.1_40423001_1 - 2.6e-18 65.8 2.7 3.9e-18 65.2 2.7 1.3 1 0 0 1 1 1 1 CXCR4 Chemokine receptor N terminal 7TM_GPCR_Srsx PF10320.7 001112630.1_40423001_1 - 3.2e-06 26.6 15.6 4.4e-06 26.1 15.6 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TctB PF07331.9 001112630.1_40423001_1 - 3.4 7.8 11.0 0.85 9.8 2.9 2.5 1 1 2 3 3 3 0 Tripartite tricarboxylate transporter TctB family COX2_TM PF02790.13 001112630.1_40423001_1 - 3.8 7.6 7.5 0.48 10.5 0.1 2.8 3 0 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane domain zf-ZPR1 PF03367.11 001168767.1_40423001_1 - 5.2e-114 377.3 1.0 1.1e-57 194.3 0.0 2.1 2 0 0 2 2 2 2 ZPR1 zinc-finger domain Zn-ribbon_8 PF09723.8 001168767.1_40423001_1 - 0.011 15.7 2.6 12 6.0 0.1 3.7 3 0 0 3 3 3 0 Zinc ribbon domain zinc-ribbons_6 PF07191.10 001168767.1_40423001_1 - 0.037 13.9 0.3 0.037 13.9 0.3 2.3 2 1 0 2 2 2 0 zinc-ribbons zf-ribbon_3 PF13248.4 001168767.1_40423001_1 - 0.042 13.2 7.1 3.2 7.1 0.2 3.5 3 0 0 3 3 3 0 zinc-ribbon domain CpXC PF14353.4 001168767.1_40423001_1 - 0.054 13.4 1.9 2.4 8.1 1.7 2.8 2 1 0 2 2 2 0 CpXC protein HypA PF01155.17 001168767.1_40423001_1 - 0.088 12.7 6.3 0.27 11.1 0.5 2.7 3 0 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF983 PF06170.10 001168767.1_40423001_1 - 0.13 12.6 0.4 15 6.0 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF983) Elf1 PF05129.11 001168767.1_40423001_1 - 0.23 11.4 1.5 3.7 7.5 0.2 2.5 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like Ogr_Delta PF04606.10 001168767.1_40423001_1 - 2.3 8.2 9.2 0.051 13.4 1.4 2.2 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger DZR PF12773.5 001168767.1_40423001_1 - 3.4 7.6 9.6 2.1 8.3 2.8 3.3 3 1 0 3 3 3 0 Double zinc ribbon zf-RRPl_C4 PF17026.3 001168767.1_40423001_1 - 3.9 7.5 6.2 6.9 6.7 0.5 2.6 3 0 0 3 3 3 0 Putative ribonucleoprotein zinc-finger pf C4 type Cathelicidins PF00666.15 001129965.1_49822001_2 - 1e-49 166.9 0.1 1.3e-49 166.5 0.1 1.1 1 0 0 1 1 1 1 Cathelicidin Spp-24 PF07448.9 001129965.1_49822001_2 - 0.0014 18.6 0.1 0.0023 17.9 0.1 1.3 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain MARCKS PF02063.15 001082318.1_37924001_1 - 2.7e-18 66.8 46.9 8e-10 39.0 35.2 2.2 1 1 1 2 2 2 2 MARCKS family 7tm_1 PF00001.19 001082134.1_37923001_1 - 8.3e-48 162.8 16.5 2.2e-47 161.4 16.5 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001082134.1_37923001_1 - 0.00034 20.0 12.9 0.00049 19.4 12.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.19 001047140.1_29623001_1 - 2.6e-46 157.9 27.4 6.8e-46 156.5 27.4 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001047140.1_29623001_1 - 5.3e-05 22.6 23.0 6.7e-05 22.3 23.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Rad51 PF08423.9 001082024.1_37923001_1 - 5.8e-129 428.7 0.1 7.1e-129 428.4 0.1 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.4 001082024.1_37923001_1 - 2.7e-10 40.0 0.0 3.8e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.19 001082024.1_37923001_1 - 2e-09 37.2 0.1 3.1e-09 36.5 0.1 1.3 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.4 001082024.1_37923001_1 - 5.7e-07 29.9 0.5 2.5e-06 27.9 0.6 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain ATPase PF06745.11 001082024.1_37923001_1 - 1.6e-05 24.2 2.0 0.00023 20.4 2.0 2.2 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.13 001082024.1_37923001_1 - 0.085 12.0 0.1 2.2 7.4 0.0 2.2 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain HHH PF00633.21 001082024.1_37923001_1 - 0.089 12.6 0.1 0.21 11.4 0.1 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif PGI PF00342.17 001082069.2_37925001_2 - 4.1e-264 876.4 0.0 4.8e-264 876.2 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase G-alpha PF00503.18 001171985.2_49824001_1 - 3.8e-108 361.7 0.4 4.8e-108 361.3 0.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 001171985.2_49824001_1 - 7.8e-16 57.9 2.8 3.9e-13 49.1 0.5 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001171985.2_49824001_1 - 0.0001 21.6 2.3 0.0019 17.4 0.2 2.4 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Roc PF08477.11 001171985.2_49824001_1 - 0.00016 21.7 1.2 0.12 12.5 0.2 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Peptidase_S49_N PF08496.8 001171985.2_49824001_1 - 0.019 14.9 2.0 0.039 13.9 2.0 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal GTP_EFTU PF00009.25 001171985.2_49824001_1 - 0.077 12.4 0.0 1.1 8.6 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_29 PF13555.4 001171985.2_49824001_1 - 0.096 12.3 0.0 0.23 11.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain CTF_NFI PF00859.16 001281695.1_31326001_3 - 1.9e-109 366.0 25.0 4.3e-109 364.9 25.0 1.6 1 0 0 1 1 1 1 CTF/NF-I family transcription modulation region NfI_DNAbd_pre-N PF10524.7 001281695.1_31326001_3 - 1.4e-26 92.0 1.7 3.4e-26 90.8 1.7 1.7 1 0 0 1 1 1 1 Nuclear factor I protein pre-N-terminus MH1 PF03165.14 001281695.1_31326001_3 - 1.8e-11 44.0 0.7 3.4e-11 43.1 0.7 1.5 1 0 0 1 1 1 1 MH1 domain G-alpha PF00503.18 001130215.2_49826001_2 - 8.1e-98 327.7 0.0 1e-97 327.3 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 001130215.2_49826001_2 - 1.7e-13 50.3 0.4 6.4e-13 48.4 0.5 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.11 001130215.2_49826001_2 - 0.059 13.5 0.6 0.19 11.8 0.2 1.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NESP55 PF06390.10 001130215.2_49826001_3 - 1.7e-121 404.6 38.0 2.4e-121 404.0 38.0 1.3 1 0 0 1 1 1 1 Neuroendocrine-specific golgi protein P55 (NESP55) CDK2AP PF09806.7 001281691.1_31322001_1 - 4.5e-20 72.6 0.0 6.2e-20 72.1 0.0 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase 2-associated protein Ribosomal_S13 PF00416.20 001285639.1_09022001_1 - 5.7e-56 188.3 4.2 6.9e-56 188.0 4.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 PP28 PF10252.7 001285639.1_09022001_1 - 0.026 14.8 0.9 0.026 14.8 0.9 2.2 2 0 0 2 2 2 0 Casein kinase substrate phosphoprotein PP28 Securin PF04856.11 001135616.2_39722001_2 - 2.6e-44 151.8 0.9 3.2e-44 151.5 0.9 1.1 1 0 0 1 1 1 1 Securin sister-chromatid separation inhibitor Lyase_1 PF00206.18 001284137.1_29524001_1 - 1.7e-25 89.9 0.0 2.5e-25 89.4 0.0 1.2 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.7 001284137.1_29524001_1 - 6.8e-19 68.1 0.0 1.7e-18 66.8 0.0 1.8 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus DUF4089 PF13318.4 001284137.1_29524001_1 - 0.0091 16.3 0.0 0.02 15.2 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF4089) HTH_Tnp_Tc5 PF03221.14 001284137.1_29524001_1 - 0.037 13.9 0.6 0.13 12.2 0.1 2.1 2 0 0 2 2 2 0 Tc5 transposase DNA-binding domain DUF1331 PF07048.9 001284137.1_29524001_1 - 0.077 12.5 0.2 0.16 11.6 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1331) Acetyltransf_1 PF00583.23 001310562.1_31323001_3 - 3e-14 53.1 0.0 4.1e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.5 001310562.1_31323001_3 - 2.9e-08 33.6 0.0 4.2e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.5 001310562.1_31323001_3 - 5.8e-06 26.5 0.0 9.5e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PIR PF00399.17 001319396.1_29523001_1 - 0.13 11.7 0.4 0.26 10.8 0.4 1.5 1 0 0 1 1 1 0 Yeast PIR protein repeat 7tm_1 PF00001.19 001319396.1_29523001_2 - 6.4e-50 169.7 15.4 1.4e-49 168.6 15.4 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CXCR4_N PF12109.6 001319396.1_29523001_2 - 2.6e-18 65.8 2.7 4e-18 65.2 2.7 1.3 1 0 0 1 1 1 1 CXCR4 Chemokine receptor N terminal 7TM_GPCR_Srsx PF10320.7 001319396.1_29523001_2 - 1.7e-05 24.2 14.3 2.3e-05 23.8 14.3 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx COX2_TM PF02790.13 001319396.1_29523001_2 - 3.2 7.8 6.7 0.49 10.4 0.1 2.7 3 0 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane domain 7tm_1 PF00001.19 001082721.1_37923001_1 - 2e-35 122.2 10.3 2.9e-35 121.7 10.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001082721.1_37923001_1 - 1e-09 38.0 10.1 2.1e-09 37.0 10.1 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001082721.1_37923001_1 - 1.8e-05 24.1 7.6 5.5e-05 22.5 6.4 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001082721.1_37923001_1 - 0.0015 18.2 2.5 0.0027 17.4 2.4 1.7 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srw PF10324.7 001082721.1_37923001_1 - 0.063 12.4 13.6 0.26 10.4 13.6 1.9 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_1 PF00001.19 001038002.1_49824001_2 - 7.5e-38 130.2 10.2 1.1e-37 129.6 10.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001038002.1_49824001_2 - 4.2e-09 36.0 11.2 8.4e-09 35.0 11.2 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001038002.1_49824001_2 - 0.00013 21.2 7.6 0.00035 19.9 6.2 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001038002.1_49824001_2 - 0.0017 18.0 0.7 0.0032 17.1 0.4 1.6 1 1 0 1 1 1 1 Olfactory receptor zf-C2H2_jaz PF12171.6 131774.1_26228120_2 - 0.00064 19.8 2.2 0.0084 16.3 0.4 2.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 131774.1_26228120_2 - 0.005 17.1 0.3 0.019 15.2 0.3 2.1 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-met PF12874.5 131774.1_26228120_3 - 0.00012 22.2 3.9 0.00035 20.7 3.9 1.8 1 0 0 1 1 1 1 Zinc-finger of C2H2 type KRAB PF01352.25 138068.1_26229120_1 - 4e-23 80.7 0.0 8.3e-23 79.7 0.0 1.6 1 0 0 1 1 1 1 KRAB box GETHR PF05671.9 138068.1_26229120_2 - 0.18 11.0 10.8 30 4.0 0.1 5.8 6 0 0 6 6 6 0 GETHR pentapeptide repeat (5 copies) zf-H2C2_2 PF13465.4 138068.1_26229120_3 - 5.1e-77 251.0 126.1 4e-09 36.4 1.2 14.7 14 0 0 14 14 14 12 Zinc-finger double domain zf-C2H2 PF00096.24 138068.1_26229120_3 - 3e-60 197.3 127.8 1.3e-06 28.4 2.1 14.6 14 0 0 14 14 14 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 138068.1_26229120_3 - 2.1e-18 65.3 139.2 0.016 15.8 0.4 15.4 16 0 0 16 16 16 12 C2H2-type zinc finger zf-C2H2_6 PF13912.4 138068.1_26229120_3 - 3.1e-07 30.0 101.3 0.07 13.0 0.2 13.6 14 0 0 14 14 14 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 138068.1_26229120_3 - 0.0063 16.5 79.0 0.0076 16.2 4.3 8.6 3 2 6 10 10 10 6 Zinc ribbon domain zinc_ribbon_15 PF17032.3 138068.1_26229120_3 - 0.0078 16.8 59.9 1.6 9.4 2.3 6.8 4 2 2 6 6 6 5 zinc-ribbon family Arm PF00514.21 001244486.1_49829001_3 - 5.5e-07 29.3 1.2 2.9 7.9 0.0 6.0 7 0 0 7 7 7 2 Armadillo/beta-catenin-like repeat V-ATPase_H_N PF03224.12 001244486.1_49829001_3 - 0.0011 18.2 0.1 0.0025 17.0 0.1 1.5 1 0 0 1 1 1 1 V-ATPase subunit H DUF3361 PF11841.6 001244486.1_49829001_3 - 0.13 12.0 1.3 6.2 6.6 0.3 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3361) LRR_4 PF12799.5 001244486.1_49829001_3 - 0.28 11.5 3.4 16 5.9 0.1 3.8 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001244486.1_49829001_3 - 8.7 6.1 10.5 4 7.2 0.2 3.6 4 0 0 4 4 4 0 Leucine rich repeat Orn_Arg_deC_N PF02784.14 001198686.1_29625001_2 - 1.3e-88 296.4 0.0 1.7e-88 296.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001198686.1_29625001_2 - 2.4e-34 117.6 0.0 6.9e-34 116.1 0.0 1.8 2 0 0 2 2 2 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Orn_Arg_deC_N PF02784.14 001291698.1_09029001_2 - 2.5e-63 213.7 0.1 3.2e-63 213.3 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001291698.1_09029001_2 - 8.6e-24 83.6 0.0 1.5e-23 82.9 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain zf-H2C2_2 PF13465.4 001108995.2_45729001_3 - 1e-170 547.1 155.2 1.3e-08 34.7 0.4 24.5 24 0 0 24 24 24 22 Zinc-finger double domain zf-C2H2 PF00096.24 001108995.2_45729001_3 - 4.4e-110 354.3 155.2 3.7e-06 27.0 2.5 23.4 23 0 0 23 23 23 22 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001108995.2_45729001_3 - 9.4e-75 240.6 151.5 0.0022 18.5 1.3 23.4 22 0 0 22 22 22 21 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001108995.2_45729001_3 - 9.8e-38 127.3 136.0 0.0093 15.8 0.4 23.7 23 0 0 23 23 23 18 C2H2-type zinc finger KRAB PF01352.25 001108995.2_45729001_3 - 4.7e-29 99.7 0.9 9.4e-24 82.7 0.4 2.5 2 0 0 2 2 2 2 KRAB box zf-C2H2_jaz PF12171.6 001108995.2_45729001_3 - 2.5e-28 97.6 101.1 0.023 14.9 0.2 22.2 23 0 0 23 23 23 13 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 001108995.2_45729001_3 - 5.5e-07 29.5 99.3 0.2 11.7 1.4 14.7 10 3 4 15 15 15 7 Zinc ribbon domain zf-H2C2_5 PF13909.4 001108995.2_45729001_3 - 4e-06 26.3 84.8 0.13 11.9 1.3 19.2 20 0 0 20 20 20 3 C2H2-type zinc-finger domain zf-BED PF02892.13 001108995.2_45729001_3 - 5e-06 26.3 125.0 0.27 11.2 2.9 20.1 4 3 16 20 20 20 5 BED zinc finger zinc_ribbon_15 PF17032.3 001108995.2_45729001_3 - 0.0028 18.2 90.6 1.2 9.8 0.6 12.7 3 2 9 13 13 13 6 zinc-ribbon family DUF3268 PF11672.6 001108995.2_45729001_3 - 0.0039 17.4 62.6 0.0086 16.3 0.6 9.6 8 2 1 11 11 11 5 zinc-finger-containing domain zf-met PF12874.5 001108995.2_45729001_3 - 0.029 14.6 128.8 0.046 14.0 2.1 18.8 20 0 0 20 20 19 0 Zinc-finger of C2H2 type BolA PF01722.16 001108995.2_45729001_3 - 0.12 12.5 6.4 19 5.5 0.1 5.1 4 2 1 5 5 5 0 BolA-like protein GAGA PF09237.9 001108995.2_45729001_3 - 0.19 11.4 11.3 3 7.6 0.1 5.9 6 0 0 6 6 6 0 GAGA factor zf-C2H2_2 PF12756.5 001108995.2_45729001_3 - 0.2 11.9 86.6 2.1 8.6 3.0 15.2 1 1 7 12 12 12 0 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.3 001108995.2_45729001_3 - 1.8 8.3 102.6 0.2 11.3 0.2 20.2 23 0 0 23 23 23 0 zinc-finger C2H2-type zf-C2HC_2 PF13913.4 001108995.2_45729001_3 - 5.1 7.0 74.0 0.71 9.7 0.1 16.4 18 0 0 18 18 18 0 zinc-finger of a C2HC-type zf-C2HE PF16278.3 001108995.2_45729001_3 - 7.7 6.9 122.6 0.05 13.9 1.1 20.4 4 2 12 17 17 17 0 C2HE / C2H2 / C2HC zinc-binding finger AAA_18 PF13238.4 001285802.1_39522001_1 - 1.2e-30 106.6 0.0 1.6e-30 106.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.4 001285802.1_39522001_1 - 1.6e-07 31.7 0.1 3.5e-07 30.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.4 001285802.1_39522001_1 - 6.2e-05 23.2 0.0 9.7e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA PF00004.27 001285802.1_39522001_1 - 0.00019 21.7 0.1 0.00039 20.7 0.1 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 001285802.1_39522001_1 - 0.00028 21.2 0.1 0.0012 19.1 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain SKI PF01202.20 001285802.1_39522001_1 - 0.0016 18.5 1.6 0.038 14.0 0.0 2.7 2 1 1 3 3 3 1 Shikimate kinase AAA_33 PF13671.4 001285802.1_39522001_1 - 0.0031 17.6 0.1 0.037 14.1 0.1 2.1 1 1 0 2 2 2 1 AAA domain ADK PF00406.20 001285802.1_39522001_1 - 0.0059 16.6 0.1 0.068 13.1 0.0 2.1 2 0 0 2 2 2 1 Adenylate kinase RuvB_N PF05496.10 001285802.1_39522001_1 - 0.0059 15.8 0.0 0.0088 15.2 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.4 001285802.1_39522001_1 - 0.0067 16.6 0.0 0.022 14.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.13 001285802.1_39522001_1 - 0.0086 15.9 0.1 0.019 14.8 0.1 1.6 1 0 0 1 1 1 1 NTPase AAA_5 PF07728.12 001285802.1_39522001_1 - 0.014 15.3 0.0 0.024 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) dNK PF01712.17 001285802.1_39522001_1 - 0.016 14.9 1.6 2.7 7.6 0.2 2.1 2 0 0 2 2 2 0 Deoxynucleoside kinase TsaE PF02367.15 001285802.1_39522001_1 - 0.023 14.6 0.1 0.035 14.0 0.1 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.11 001285802.1_39522001_1 - 0.032 13.4 0.7 0.42 9.8 0.0 2.0 2 0 0 2 2 2 0 KaiC Cytidylate_kin PF02224.16 001285802.1_39522001_1 - 0.042 13.4 0.0 0.058 13.0 0.0 1.2 1 0 0 1 1 1 0 Cytidylate kinase AAA_24 PF13479.4 001285802.1_39522001_1 - 0.05 13.2 0.1 0.12 12.0 0.1 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.20 001285802.1_39522001_1 - 0.057 13.7 0.0 0.093 13.0 0.0 1.3 1 0 0 1 1 1 0 RNA helicase AAA_3 PF07726.9 001285802.1_39522001_1 - 0.13 12.0 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Exostosin PF03016.13 001355076.1_32928001_3 - 1.2e-56 192.0 0.0 1.6e-56 191.6 0.0 1.2 1 0 0 1 1 1 1 Exostosin family Glyco_transf_64 PF09258.8 001355076.1_32928001_3 - 1.8e-28 99.4 0.1 2.8e-28 98.8 0.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Methyltr_RsmB-F PF01189.15 001244246.1_49826001_3 - 8.8e-84 280.0 0.0 1.5e-83 279.3 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.3 001244246.1_49826001_3 - 2.6e-09 37.3 0.0 6e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.17 001244246.1_49826001_3 - 0.00092 19.2 0.0 0.0018 18.3 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase P120R PF08062.9 001244246.1_49826001_3 - 0.0016 18.5 25.5 0.0079 16.3 1.1 4.3 3 0 0 3 3 3 2 P120R (NUC006) repeat Methyltransf_25 PF13649.4 001244246.1_49826001_3 - 0.006 17.1 0.0 0.016 15.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.17 001244246.1_49826001_3 - 0.017 14.7 0.0 0.029 14.0 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF2431 PF10354.7 001244246.1_49826001_3 - 0.038 14.2 0.0 0.071 13.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) Methyltransf_31 PF13847.4 001244246.1_49826001_3 - 0.054 13.2 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain IIGP PF05049.11 001289890.1_24224001_1 - 8e-64 215.9 0.0 1e-63 215.6 0.0 1.0 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Retrotrans_gag PF03732.15 001291297.1_09029001_1 - 3.1e-15 56.1 2.5 4.6e-15 55.6 0.1 2.1 2 0 0 2 2 2 1 Retrotransposon gag protein DUF4939 PF16297.3 001291297.1_09029001_1 - 7.5e-15 54.6 0.0 1.3e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) zf-CCHC_5 PF14787.4 001291297.1_09029001_1 - 0.0021 17.6 0.2 0.0048 16.4 0.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger KASH_CCD PF14662.4 001291297.1_09029001_1 - 0.012 15.4 4.7 0.019 14.7 4.7 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Rootletin PF15035.4 001291297.1_09029001_1 - 0.054 13.4 6.3 0.098 12.6 6.3 1.3 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion zf-CCHC PF00098.21 001291297.1_09029001_1 - 0.087 12.8 2.2 0.34 10.9 2.2 2.2 1 0 0 1 1 1 0 Zinc knuckle TPR_MLP1_2 PF07926.10 001291297.1_09029001_1 - 0.23 11.4 4.6 0.42 10.5 4.6 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein SHE3 PF17078.3 001291297.1_09029001_1 - 0.24 10.9 5.0 0.41 10.2 5.0 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Mito_fiss_reg PF05308.9 001291297.1_09029001_1 - 0.53 10.2 5.0 1.2 9.0 5.0 1.6 1 0 0 1 1 1 0 Mitochondrial fission regulator Spc7 PF08317.9 001291297.1_09029001_1 - 0.63 8.7 4.3 1.1 8.0 4.3 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF972 PF06156.11 001291297.1_09029001_1 - 0.65 10.5 3.7 1.4 9.4 3.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) ZapB PF06005.10 001291297.1_09029001_1 - 1 9.7 9.0 2.2 8.6 9.0 1.5 1 0 0 1 1 1 0 Cell division protein ZapB DivIC PF04977.13 001291297.1_09029001_1 - 5.8 6.6 4.9 14 5.4 4.9 1.6 1 0 0 1 1 1 0 Septum formation initiator Asp_protease_2 PF13650.4 001291297.1_09029001_3 - 0.00063 20.2 0.0 0.0011 19.5 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001291297.1_09029001_3 - 0.013 15.3 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001291297.1_09029001_3 - 0.06 13.8 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Orn_Arg_deC_N PF02784.14 001293722.1_39524001_2 - 1.5e-70 237.3 0.0 1.9e-70 237.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001293722.1_39524001_2 - 6.2e-18 64.8 0.0 1.2e-17 63.9 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.22 001293722.1_39524001_2 - 0.00013 21.3 0.0 0.00029 20.2 0.0 1.6 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel ODC_AZ PF02100.15 001301483.1_09022001_3 - 5.2e-15 55.3 0.0 7.4e-15 54.8 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Retrotrans_gag PF03732.15 001291298.1_09029001_1 - 3.1e-15 56.1 2.5 4.6e-15 55.6 0.1 2.1 2 0 0 2 2 2 1 Retrotransposon gag protein DUF4939 PF16297.3 001291298.1_09029001_1 - 7.5e-15 54.6 0.0 1.3e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) zf-CCHC_5 PF14787.4 001291298.1_09029001_1 - 0.0021 17.6 0.2 0.0048 16.4 0.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger KASH_CCD PF14662.4 001291298.1_09029001_1 - 0.012 15.4 4.7 0.019 14.7 4.7 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Rootletin PF15035.4 001291298.1_09029001_1 - 0.054 13.4 6.3 0.098 12.6 6.3 1.3 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion zf-CCHC PF00098.21 001291298.1_09029001_1 - 0.087 12.8 2.2 0.34 10.9 2.2 2.2 1 0 0 1 1 1 0 Zinc knuckle TPR_MLP1_2 PF07926.10 001291298.1_09029001_1 - 0.23 11.4 4.6 0.42 10.5 4.6 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein SHE3 PF17078.3 001291298.1_09029001_1 - 0.24 10.9 5.0 0.41 10.2 5.0 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Mito_fiss_reg PF05308.9 001291298.1_09029001_1 - 0.53 10.2 5.0 1.2 9.0 5.0 1.6 1 0 0 1 1 1 0 Mitochondrial fission regulator Spc7 PF08317.9 001291298.1_09029001_1 - 0.63 8.7 4.3 1.1 8.0 4.3 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF972 PF06156.11 001291298.1_09029001_1 - 0.65 10.5 3.7 1.4 9.4 3.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) ZapB PF06005.10 001291298.1_09029001_1 - 1 9.7 9.0 2.2 8.6 9.0 1.5 1 0 0 1 1 1 0 Cell division protein ZapB DivIC PF04977.13 001291298.1_09029001_1 - 5.8 6.6 4.9 14 5.4 4.9 1.6 1 0 0 1 1 1 0 Septum formation initiator Asp_protease_2 PF13650.4 001291298.1_09029001_3 - 0.00063 20.2 0.0 0.0011 19.5 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001291298.1_09029001_3 - 0.013 15.3 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001291298.1_09029001_3 - 0.06 13.8 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Keratin_matx PF04579.10 033185.2_26222001_1 - 1.1e-42 144.2 38.6 1.4e-42 143.8 38.6 1.2 1 0 0 1 1 1 1 Keratin, high-sulphur matrix protein OAD_gamma PF04277.11 033185.2_26222001_3 - 4.1 7.9 6.0 7.9 7.0 6.0 1.5 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF4745 PF15923.3 001271233.1_45729001_2 - 2.8e-52 176.1 1.3 2.8e-52 176.1 1.3 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4745) DUF4617 PF15395.4 001243821.1_49829001_2 - 0 1545.6 90.4 0 1545.6 90.4 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4617) Asp_protease_2 PF13650.4 001291091.1_24229001_2 - 0.00077 20.0 0.0 0.0013 19.3 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001291091.1_24229001_2 - 0.016 15.1 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001291091.1_24229001_2 - 0.052 14.0 0.0 0.086 13.3 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DUF4939 PF16297.3 001291091.1_24229001_3 - 5.4e-15 55.1 0.0 9.9e-15 54.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Retrotrans_gag PF03732.15 001291091.1_24229001_3 - 1.3e-14 54.1 1.9 5e-14 52.2 0.0 2.2 2 0 0 2 2 2 1 Retrotransposon gag protein Rootletin PF15035.4 001291091.1_24229001_3 - 0.00034 20.6 0.1 0.00065 19.7 0.1 1.4 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion KASH_CCD PF14662.4 001291091.1_24229001_3 - 0.002 17.9 4.7 0.0033 17.2 4.7 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH zf-CCHC_5 PF14787.4 001291091.1_24229001_3 - 0.0028 17.2 0.2 0.0064 16.0 0.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger Spc29 PF17082.3 001291091.1_24229001_3 - 0.0068 16.1 0.4 0.011 15.5 0.4 1.2 1 0 0 1 1 1 1 Spindle Pole Component 29 CCDC106 PF15794.3 001291091.1_24229001_3 - 0.14 11.7 3.8 0.55 9.8 2.2 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 CENP-H PF05837.10 001291091.1_24229001_3 - 0.24 11.7 4.8 0.47 10.8 4.8 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) ZapB PF06005.10 001291091.1_24229001_3 - 0.32 11.3 9.2 0.68 10.3 9.2 1.5 1 0 0 1 1 1 0 Cell division protein ZapB DUF972 PF06156.11 001291091.1_24229001_3 - 0.34 11.4 3.8 0.79 10.2 3.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Spc7 PF08317.9 001291091.1_24229001_3 - 0.37 9.5 3.4 0.65 8.7 3.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF5082 PF16888.3 001291091.1_24229001_3 - 0.39 10.9 3.9 0.68 10.2 2.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) SHE3 PF17078.3 001291091.1_24229001_3 - 0.79 9.3 7.3 1.6 8.3 7.3 1.4 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 DivIC PF04977.13 001291091.1_24229001_3 - 1.2 8.8 5.9 2.3 7.9 5.9 1.4 1 0 0 1 1 1 0 Septum formation initiator bZIP_1 PF00170.19 001291091.1_24229001_3 - 1.5 8.8 8.4 3.3 7.7 8.4 1.5 1 0 0 1 1 1 0 bZIP transcription factor IncA PF04156.12 001291091.1_24229001_3 - 1.7 8.3 5.3 3.2 7.4 5.3 1.3 1 0 0 1 1 1 0 IncA protein GIT_CC PF16559.3 001291091.1_24229001_3 - 2.2 8.3 7.1 5.2 7.0 7.1 1.6 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor TSC22 PF01166.16 001291091.1_24229001_3 - 7 6.9 7.5 39 4.5 7.5 2.1 1 1 0 1 1 1 0 TSC-22/dip/bun family zf-H2C2_2 PF13465.4 001163062.1_45725001_1 - 2.6e-67 220.3 88.2 2.6e-07 30.6 2.9 14.0 15 0 0 15 15 14 11 Zinc-finger double domain zf-C2H2 PF00096.24 001163062.1_45725001_1 - 1.9e-48 160.1 88.1 3.1e-05 24.0 1.6 13.5 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001163062.1_45725001_1 - 8.7e-38 125.6 87.0 0.0011 19.4 0.6 13.6 13 0 0 13 13 13 12 C2H2-type zinc finger KRAB PF01352.25 001163062.1_45725001_1 - 4.3e-23 80.6 0.1 6.8e-23 79.9 0.1 1.3 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 001163062.1_45725001_1 - 5e-22 77.6 41.4 0.063 13.5 0.1 12.8 13 0 0 13 13 12 8 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001163062.1_45725001_1 - 3.3e-15 55.5 67.8 0.0092 15.8 0.5 11.7 11 0 0 11 11 11 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001163062.1_45725001_1 - 4.2e-14 52.3 45.0 0.0026 17.7 1.5 8.9 6 3 3 9 9 9 6 Zinc ribbon domain XPA_N PF01286.16 001163062.1_45725001_1 - 2.3e-12 46.6 31.5 0.02 14.8 0.0 11.5 11 0 0 11 11 11 2 XPA protein N-terminal zf-C2H2_11 PF16622.3 001163062.1_45725001_1 - 3.4e-08 33.0 70.3 0.00022 20.8 0.6 12.7 14 0 0 14 14 13 5 zinc-finger C2H2-type zf-trcl PF13451.4 001163062.1_45725001_1 - 1.6e-06 27.7 43.7 0.48 10.2 1.4 10.3 10 1 0 10 10 10 2 Probable zinc-ribbon domain ADK_lid PF05191.12 001163062.1_45725001_1 - 3.9e-05 23.4 42.1 0.051 13.5 1.8 8.3 4 2 5 9 9 9 3 Adenylate kinase, active site lid zinc_ribbon_15 PF17032.3 001163062.1_45725001_1 - 4.1e-05 24.1 39.8 0.053 14.2 1.1 6.5 2 1 5 7 7 7 5 zinc-ribbon family DUF3268 PF11672.6 001163062.1_45725001_1 - 0.14 12.4 42.4 0.23 11.7 2.0 7.1 3 2 4 9 9 9 0 zinc-finger-containing domain zf-met PF12874.5 001163062.1_45725001_1 - 0.15 12.3 66.6 0.66 10.3 0.1 12.5 13 0 0 13 13 13 0 Zinc-finger of C2H2 type FerB PF08150.10 001163062.1_45725001_1 - 0.22 12.0 8.6 2.5 8.6 0.1 4.0 2 2 3 5 5 5 0 FerB (NUC096) domain TFIIS_C PF01096.16 001163062.1_45725001_1 - 0.32 10.7 46.0 0.21 11.3 2.9 8.7 9 0 0 9 9 9 0 Transcription factor S-II (TFIIS) FYDLN_acid PF09538.8 001163062.1_45725001_1 - 0.9 10.1 19.9 26 5.4 1.0 7.5 2 1 4 7 7 7 0 Protein of unknown function (FYDLN_acid) zf-C2HC_2 PF13913.4 001163062.1_45725001_1 - 1.3 8.9 53.2 1.2 8.9 0.2 11.2 11 1 0 11 11 11 0 zinc-finger of a C2HC-type zf-LYAR PF08790.9 001163062.1_45725001_1 - 3.9 7.3 47.6 0.73 9.7 0.1 9.9 10 0 0 10 10 9 0 LYAR-type C2HC zinc finger FYVE PF01363.19 001163062.1_45725001_1 - 5.7 7.0 52.6 4.6 7.3 7.1 7.2 2 1 5 7 7 6 0 FYVE zinc finger zf-RRPl_C4 PF17026.3 001163062.1_45725001_1 - 9.1 6.3 28.3 1.3 9.0 5.2 4.3 1 1 3 4 4 4 0 Putative ribonucleoprotein zinc-finger pf C4 type SCAN PF02023.15 001169143.1_45724001_1 - 1.8e-33 114.1 0.1 3.5e-33 113.2 0.1 1.4 1 0 0 1 1 1 1 SCAN domain zf-H2C2_2 PF13465.4 001169143.1_45724001_1 - 1.9e-12 46.9 35.9 7.4e-07 29.2 2.5 5.3 5 1 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.24 001169143.1_45724001_1 - 1.4e-11 44.0 33.2 3.9e-05 23.7 3.1 4.7 4 1 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001169143.1_45724001_1 - 1.5e-06 28.4 29.6 0.0013 19.2 1.9 4.6 4 0 0 4 4 4 4 C2H2-type zinc finger DZR PF12773.5 001169143.1_45724001_1 - 0.009 15.9 0.5 0.009 15.9 0.5 2.6 2 1 0 2 2 2 1 Double zinc ribbon Zn-ribbon_8 PF09723.8 001169143.1_45724001_1 - 0.013 15.5 13.9 0.32 11.0 0.3 3.8 3 1 0 3 3 3 0 Zinc ribbon domain zinc_ribbon_9 PF14369.4 001169143.1_45724001_1 - 0.055 13.6 11.2 4.9 7.4 0.2 4.5 4 0 0 4 4 4 0 zinc-ribbon zf-LYAR PF08790.9 001169143.1_45724001_1 - 0.99 9.2 6.0 11 5.9 0.4 3.5 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger FYDLN_acid PF09538.8 001169143.1_45724001_1 - 1.1 9.8 6.0 10 6.7 0.1 3.6 2 2 1 3 3 3 0 Protein of unknown function (FYDLN_acid) CpXC PF14353.4 001169143.1_45724001_1 - 6.6 6.7 8.7 27 4.7 0.0 3.5 3 1 1 4 4 4 0 CpXC protein zf-Di19 PF05605.10 001169143.1_45724001_1 - 9.2 6.5 11.2 0.11 12.7 2.3 2.2 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding CAP PF00188.24 001131.2_26224001_2 - 2.6e-17 63.7 1.1 4e-17 63.1 1.1 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Crisp PF08562.8 001131.2_26224001_2 - 4.1e-17 62.4 16.5 9.8e-17 61.2 16.5 1.7 1 0 0 1 1 1 1 Crisp Asp_protease_2 PF13650.4 001290793.2_39525001_2 - 0.00018 22.0 0.0 0.00031 21.2 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001290793.2_39525001_2 - 0.0034 17.2 0.0 0.0059 16.5 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001290793.2_39525001_2 - 0.017 15.5 0.0 0.029 14.8 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Retrotrans_gag PF03732.15 001290793.2_39525001_3 - 3e-16 59.3 2.4 1.3e-15 57.3 0.1 2.3 2 0 0 2 2 2 1 Retrotransposon gag protein DUF4939 PF16297.3 001290793.2_39525001_3 - 2.2e-15 56.4 0.0 3.7e-15 55.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) zf-CCHC_5 PF14787.4 001290793.2_39525001_3 - 0.00066 19.2 0.2 0.0016 18.0 0.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger KASH_CCD PF14662.4 001290793.2_39525001_3 - 0.0042 16.8 5.3 0.0071 16.1 5.3 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH Spc7 PF08317.9 001290793.2_39525001_3 - 0.045 12.5 4.1 0.12 11.1 3.9 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein V_ATPase_I PF01496.17 001290793.2_39525001_3 - 0.046 11.5 0.3 0.063 11.0 0.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family eIF3g PF12353.6 001290793.2_39525001_3 - 0.058 13.6 0.2 0.17 12.1 0.2 1.8 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G ERM PF00769.17 001290793.2_39525001_3 - 0.095 12.4 6.7 0.2 11.3 6.7 1.5 1 0 0 1 1 1 0 Ezrin/radixin/moesin family CENP-H PF05837.10 001290793.2_39525001_3 - 0.098 12.9 2.5 0.28 11.5 2.5 1.7 1 0 0 1 1 1 0 Centromere protein H (CENP-H) YtxH PF12732.5 001290793.2_39525001_3 - 0.19 12.2 0.6 0.34 11.4 0.6 1.4 1 0 0 1 1 1 0 YtxH-like protein CAMP_factor PF07373.9 001290793.2_39525001_3 - 0.2 11.1 0.7 4.3 6.7 0.3 2.1 2 0 0 2 2 2 0 CAMP factor (Cfa) CAP_N PF01213.17 001290793.2_39525001_3 - 0.21 10.9 4.7 0.44 9.9 4.7 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal IncA PF04156.12 001290793.2_39525001_3 - 0.23 11.1 3.4 0.54 9.9 3.4 1.5 1 0 0 1 1 1 0 IncA protein bZIP_1 PF00170.19 001290793.2_39525001_3 - 0.23 11.5 7.0 0.95 9.5 6.8 2.1 1 1 0 1 1 1 0 bZIP transcription factor SHE3 PF17078.3 001290793.2_39525001_3 - 0.28 10.7 7.3 0.14 11.7 5.2 1.5 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 TPR_MLP1_2 PF07926.10 001290793.2_39525001_3 - 0.32 10.9 7.4 0.46 10.4 6.3 1.8 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Rootletin PF15035.4 001290793.2_39525001_3 - 0.69 9.8 12.4 0.083 12.8 8.0 1.6 2 0 0 2 2 1 0 Ciliary rootlet component, centrosome cohesion DUF972 PF06156.11 001290793.2_39525001_3 - 0.81 10.2 6.5 0.6 10.6 4.4 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF972) ZapB PF06005.10 001290793.2_39525001_3 - 0.96 9.8 10.9 2.5 8.5 10.9 1.6 1 0 0 1 1 1 0 Cell division protein ZapB zf-CCHC PF00098.21 001290793.2_39525001_3 - 1.6 8.8 8.0 0.11 12.4 2.2 2.3 2 0 0 2 2 2 0 Zinc knuckle TSC22 PF01166.16 001290793.2_39525001_3 - 2.1 8.6 7.7 33 4.8 7.7 2.2 1 1 0 1 1 1 0 TSC-22/dip/bun family DivIC PF04977.13 001290793.2_39525001_3 - 7.7 6.2 7.6 4.2 7.1 4.9 1.9 2 0 0 2 2 2 0 Septum formation initiator APG6 PF04111.10 001290793.2_39525001_3 - 8 5.6 7.9 1.6 7.9 4.1 1.6 2 0 0 2 2 2 0 Autophagy protein Apg6 Asp_protease_2 PF13650.4 001291092.1_24229001_2 - 0.00077 20.0 0.0 0.0013 19.3 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001291092.1_24229001_2 - 0.016 15.1 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001291092.1_24229001_2 - 0.052 14.0 0.0 0.086 13.3 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DUF4939 PF16297.3 001291092.1_24229001_3 - 5.4e-15 55.1 0.0 9.9e-15 54.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Retrotrans_gag PF03732.15 001291092.1_24229001_3 - 1.3e-14 54.1 1.9 5e-14 52.2 0.0 2.2 2 0 0 2 2 2 1 Retrotransposon gag protein Rootletin PF15035.4 001291092.1_24229001_3 - 0.00034 20.6 0.1 0.00065 19.7 0.1 1.4 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion KASH_CCD PF14662.4 001291092.1_24229001_3 - 0.002 17.9 4.7 0.0033 17.2 4.7 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH zf-CCHC_5 PF14787.4 001291092.1_24229001_3 - 0.0028 17.2 0.2 0.0064 16.0 0.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger Spc29 PF17082.3 001291092.1_24229001_3 - 0.0068 16.1 0.4 0.011 15.5 0.4 1.2 1 0 0 1 1 1 1 Spindle Pole Component 29 CCDC106 PF15794.3 001291092.1_24229001_3 - 0.14 11.7 3.8 0.55 9.8 2.2 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 CENP-H PF05837.10 001291092.1_24229001_3 - 0.24 11.7 4.8 0.47 10.8 4.8 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) ZapB PF06005.10 001291092.1_24229001_3 - 0.32 11.3 9.2 0.68 10.3 9.2 1.5 1 0 0 1 1 1 0 Cell division protein ZapB DUF972 PF06156.11 001291092.1_24229001_3 - 0.34 11.4 3.8 0.79 10.2 3.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Spc7 PF08317.9 001291092.1_24229001_3 - 0.37 9.5 3.4 0.65 8.7 3.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF5082 PF16888.3 001291092.1_24229001_3 - 0.39 10.9 3.9 0.68 10.2 2.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) SHE3 PF17078.3 001291092.1_24229001_3 - 0.79 9.3 7.3 1.6 8.3 7.3 1.4 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 DivIC PF04977.13 001291092.1_24229001_3 - 1.2 8.8 5.9 2.3 7.9 5.9 1.4 1 0 0 1 1 1 0 Septum formation initiator bZIP_1 PF00170.19 001291092.1_24229001_3 - 1.5 8.8 8.4 3.3 7.7 8.4 1.5 1 0 0 1 1 1 0 bZIP transcription factor IncA PF04156.12 001291092.1_24229001_3 - 1.7 8.3 5.3 3.2 7.4 5.3 1.3 1 0 0 1 1 1 0 IncA protein GIT_CC PF16559.3 001291092.1_24229001_3 - 2.2 8.3 7.1 5.2 7.0 7.1 1.6 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor TSC22 PF01166.16 001291092.1_24229001_3 - 7 6.9 7.5 39 4.5 7.5 2.1 1 1 0 1 1 1 0 TSC-22/dip/bun family Orn_Arg_deC_N PF02784.14 001293721.1_22424001_1 - 2.7e-64 216.9 0.0 3.3e-64 216.6 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001293721.1_22424001_1 - 5.9e-20 71.3 0.0 1e-19 70.5 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.22 001293721.1_22424001_1 - 0.0023 17.2 0.0 0.0052 16.1 0.0 1.5 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel zf-LITAF-like PF10601.7 001244099.1_49825001_3 - 4.3e-22 78.0 13.9 7.9e-22 77.2 13.9 1.5 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain TPR_19 PF14559.4 001204395.2_49825001_1 - 3.9e-16 59.2 5.1 0.0052 17.1 0.0 4.6 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.4 001204395.2_49825001_1 - 2e-15 55.8 12.7 0.015 15.5 0.1 7.8 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.15 001204395.2_49825001_1 - 2.7e-13 48.8 25.9 0.0076 16.2 0.0 7.8 9 0 0 9 9 7 4 Tetratricopeptide repeat TPR_8 PF13181.4 001204395.2_49825001_1 - 6.3e-12 44.6 25.6 0.067 13.3 0.9 8.0 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_1 PF00515.26 001204395.2_49825001_1 - 4.4e-11 42.0 23.1 0.031 14.0 0.1 7.3 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_12 PF13424.4 001204395.2_49825001_1 - 3.5e-10 39.9 13.8 4e-08 33.3 0.5 5.3 5 1 1 6 6 5 2 Tetratricopeptide repeat TPR_14 PF13428.4 001204395.2_49825001_1 - 7.1e-10 38.7 4.3 0.31 11.8 0.0 7.0 3 2 4 7 7 7 1 Tetratricopeptide repeat TPR_11 PF13414.4 001204395.2_49825001_1 - 2.8e-09 36.4 14.3 0.025 14.1 0.1 6.5 6 0 0 6 6 6 3 TPR repeat TPR_16 PF13432.4 001204395.2_49825001_1 - 1.7e-08 34.9 3.8 0.0063 17.0 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.4 001204395.2_49825001_1 - 0.00093 19.5 8.3 19 6.0 0.0 6.7 7 0 0 7 7 7 0 Tetratricopeptide repeat ChAPs PF09295.8 001204395.2_49825001_1 - 0.0012 17.8 0.1 0.0025 16.8 0.1 1.5 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_7 PF13176.4 001204395.2_49825001_1 - 0.003 17.3 3.4 1.6 8.8 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat NARP1 PF12569.6 001204395.2_49825001_1 - 0.0066 15.3 9.2 0.015 14.0 0.0 3.6 2 1 2 4 4 4 1 NMDA receptor-regulated protein 1 PUL PF08324.9 001204395.2_49825001_1 - 0.032 13.4 0.1 0.074 12.2 0.1 1.6 1 0 0 1 1 1 0 PUL domain TPR_10 PF13374.4 001204395.2_49825001_1 - 0.035 13.9 13.1 6.7 6.6 0.0 5.8 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_15 PF13429.4 001204395.2_49825001_1 - 0.076 12.1 7.1 0.68 9.0 0.2 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_20 PF14561.4 001204395.2_49825001_1 - 2.3 8.5 8.6 6.1 7.1 0.5 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat Orn_Arg_deC_N PF02784.14 001291697.1_09029001_1 - 2.7e-63 213.6 0.1 3.3e-63 213.3 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001291697.1_09029001_1 - 9e-24 83.6 0.0 1.6e-23 82.8 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Orn_Arg_deC_N PF02784.14 001293756.1_09024001_2 - 1.5e-70 237.3 0.0 1.9e-70 237.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001293756.1_09024001_2 - 1.1e-17 64.0 0.0 2.1e-17 63.1 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.22 001293756.1_09024001_2 - 0.00013 21.4 0.0 0.00029 20.2 0.0 1.6 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Asp_protease_2 PF13650.4 001291300.1_09029001_1 - 0.00063 20.3 0.0 0.0011 19.5 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001291300.1_09029001_1 - 0.013 15.3 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001291300.1_09029001_1 - 0.06 13.8 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Retrotrans_gag PF03732.15 001291300.1_09029001_2 - 3.1e-15 56.1 2.5 4.6e-15 55.6 0.1 2.1 2 0 0 2 2 2 1 Retrotransposon gag protein DUF4939 PF16297.3 001291300.1_09029001_2 - 7.6e-15 54.6 0.0 1.3e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) zf-CCHC_5 PF14787.4 001291300.1_09029001_2 - 0.002 17.7 0.2 0.0048 16.4 0.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger KASH_CCD PF14662.4 001291300.1_09029001_2 - 0.012 15.3 4.7 0.019 14.7 4.7 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Rootletin PF15035.4 001291300.1_09029001_2 - 0.055 13.4 6.3 0.098 12.6 6.3 1.3 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion zf-CCHC PF00098.21 001291300.1_09029001_2 - 0.079 12.9 2.2 0.34 10.9 2.2 2.2 1 0 0 1 1 1 0 Zinc knuckle TPR_MLP1_2 PF07926.10 001291300.1_09029001_2 - 0.23 11.4 4.6 0.42 10.5 4.6 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein SHE3 PF17078.3 001291300.1_09029001_2 - 0.24 10.9 5.0 0.41 10.2 5.0 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Spc7 PF08317.9 001291300.1_09029001_2 - 0.63 8.7 4.3 1.1 8.0 4.3 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF972 PF06156.11 001291300.1_09029001_2 - 0.65 10.5 3.7 1.4 9.4 3.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Mito_fiss_reg PF05308.9 001291300.1_09029001_2 - 0.76 9.7 5.3 1.7 8.5 5.3 1.6 1 0 0 1 1 1 0 Mitochondrial fission regulator ZapB PF06005.10 001291300.1_09029001_2 - 1 9.7 9.0 2.2 8.6 9.0 1.5 1 0 0 1 1 1 0 Cell division protein ZapB DivIC PF04977.13 001291300.1_09029001_2 - 5.9 6.6 4.9 14 5.4 4.9 1.5 1 0 0 1 1 1 0 Septum formation initiator LRR_9 PF14580.4 001282069.1_22422001_1 - 6.2e-13 48.5 0.0 4.2e-12 45.8 0.0 2.0 1 1 1 2 2 2 1 Leucine-rich repeat LRR_8 PF13855.4 001282069.1_22422001_1 - 8.7e-07 28.5 1.8 8.7e-07 28.5 1.8 2.4 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.5 001282069.1_22422001_1 - 2.5e-05 24.4 10.2 0.00033 20.8 0.2 3.4 1 1 3 4 4 4 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001282069.1_22422001_1 - 3.2 8.4 7.5 1.1e+02 3.8 0.0 4.3 4 0 0 4 4 4 0 Leucine Rich Repeat CD225 PF04505.10 001304278.1_39522001_3 - 8.3e-11 41.7 2.8 1.5e-10 40.9 2.8 1.4 1 0 0 1 1 1 1 Interferon-induced transmembrane protein RRM_1 PF00076.20 001243829.1_49824001_1 - 2.7e-09 36.6 0.0 4.8e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPOB_a PF14689.4 001243829.1_49824001_2 - 0.051 13.2 0.2 0.097 12.3 0.2 1.4 1 0 0 1 1 1 0 Sensor_kinase_SpoOB-type, alpha-helical domain PetM PF08041.9 001190873.1_29622001_2 - 0.13 11.7 0.1 0.21 11.1 0.1 1.3 1 0 0 1 1 1 0 PetM family of cytochrome b6f complex subunit 7 DUF4508 PF14969.4 001190873.1_29622001_3 - 2.1e-35 120.7 0.8 2.6e-35 120.4 0.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4508) DUF4507 PF14964.4 001190873.1_29622001_3 - 0.061 12.1 0.0 0.076 11.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4507) Beta-TrCP_D PF12125.6 001190873.1_29622001_3 - 0.96 9.3 3.9 4 7.3 0.8 2.5 2 1 0 2 2 2 0 D domain of beta-TrCP PLAC9 PF15205.4 001190209.1_49823001_2 - 4.1e-45 151.9 0.1 8e-45 151.0 0.1 1.5 1 0 0 1 1 1 1 Placenta-specific protein 9 zf-H2C2_2 PF13465.4 001271280.1_45728001_2 - 1.7e-94 306.3 90.2 1.2e-08 34.9 0.5 13.5 13 0 0 13 13 13 12 Zinc-finger double domain zf-C2H2 PF00096.24 001271280.1_45728001_2 - 1.2e-67 220.7 105.0 1e-06 28.7 2.6 13.4 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001271280.1_45728001_2 - 1.8e-38 127.7 96.7 0.0011 19.5 2.5 13.4 12 0 0 12 12 12 12 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001271280.1_45728001_2 - 1.9e-23 81.7 82.2 0.0022 17.8 0.7 13.1 13 0 0 13 13 13 11 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001271280.1_45728001_2 - 1.3e-14 53.8 48.4 0.0064 16.5 1.1 8.3 4 4 3 8 8 8 7 Zinc ribbon domain DUF3268 PF11672.6 001271280.1_45728001_2 - 3.8e-07 30.3 39.7 0.034 14.3 0.5 6.5 6 0 0 6 6 6 4 zinc-finger-containing domain CpXC PF14353.4 001271280.1_45728001_2 - 1e-06 28.6 42.0 0.95 9.4 0.1 10.8 10 2 1 11 11 11 5 CpXC protein zf-C2H2_jaz PF12171.6 001271280.1_45728001_2 - 1.5e-05 25.1 72.4 0.61 10.3 0.6 12.6 12 0 0 12 12 12 5 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 001271280.1_45728001_2 - 0.0013 18.6 55.7 1.6 8.7 0.1 12.2 12 0 0 12 12 12 4 XPA protein N-terminal zinc_ribbon_15 PF17032.3 001271280.1_45728001_2 - 0.0069 17.0 52.2 0.53 10.9 2.6 7.2 1 1 9 10 10 10 7 zinc-ribbon family Csm1 PF12539.6 001271280.1_45728001_2 - 0.013 16.0 8.8 21 5.7 0.3 5.5 4 1 1 5 5 5 0 Chromosome segregation protein Csm1/Pcs1 zf-AN1 PF01428.14 001271280.1_45728001_2 - 0.021 14.8 57.7 8.8 6.5 0.4 12.4 11 1 1 12 12 12 0 AN1-like Zinc finger zf-trcl PF13451.4 001271280.1_45728001_2 - 0.13 12.0 42.5 8.5 6.2 0.1 11.2 11 1 1 12 12 12 0 Probable zinc-ribbon domain zf-C2HE PF16278.3 001271280.1_45728001_2 - 3.3 8.1 69.1 6.4 7.2 0.7 12.6 4 3 7 11 11 11 0 C2HE / C2H2 / C2HC zinc-binding finger Asp_protease_2 PF13650.4 001291299.1_09029001_1 - 0.00063 20.3 0.0 0.0011 19.5 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001291299.1_09029001_1 - 0.013 15.3 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001291299.1_09029001_1 - 0.06 13.8 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Retrotrans_gag PF03732.15 001291299.1_09029001_2 - 3.1e-15 56.1 2.5 4.6e-15 55.6 0.1 2.1 2 0 0 2 2 2 1 Retrotransposon gag protein DUF4939 PF16297.3 001291299.1_09029001_2 - 7.6e-15 54.6 0.0 1.3e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) zf-CCHC_5 PF14787.4 001291299.1_09029001_2 - 0.002 17.7 0.2 0.0048 16.4 0.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger KASH_CCD PF14662.4 001291299.1_09029001_2 - 0.012 15.3 4.7 0.019 14.7 4.7 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Rootletin PF15035.4 001291299.1_09029001_2 - 0.055 13.4 6.3 0.098 12.6 6.3 1.3 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion zf-CCHC PF00098.21 001291299.1_09029001_2 - 0.079 12.9 2.2 0.34 10.9 2.2 2.2 1 0 0 1 1 1 0 Zinc knuckle TPR_MLP1_2 PF07926.10 001291299.1_09029001_2 - 0.23 11.4 4.6 0.42 10.5 4.6 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein SHE3 PF17078.3 001291299.1_09029001_2 - 0.24 10.9 5.0 0.41 10.2 5.0 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Spc7 PF08317.9 001291299.1_09029001_2 - 0.63 8.7 4.3 1.1 8.0 4.3 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF972 PF06156.11 001291299.1_09029001_2 - 0.65 10.5 3.7 1.4 9.4 3.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Mito_fiss_reg PF05308.9 001291299.1_09029001_2 - 0.76 9.7 5.3 1.7 8.5 5.3 1.6 1 0 0 1 1 1 0 Mitochondrial fission regulator ZapB PF06005.10 001291299.1_09029001_2 - 1 9.7 9.0 2.2 8.6 9.0 1.5 1 0 0 1 1 1 0 Cell division protein ZapB DivIC PF04977.13 001291299.1_09029001_2 - 5.9 6.6 4.9 14 5.4 4.9 1.5 1 0 0 1 1 1 0 Septum formation initiator Cadherin PF00028.15 001198669.1_29626001_1 - 3.2e-82 271.0 0.0 1.2e-18 67.2 0.0 6.4 5 1 1 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001198669.1_29626001_1 - 9e-35 118.2 2.5 2.6e-29 100.7 0.1 5.0 5 0 0 5 5 5 3 Cadherin-like Cadherin_C_2 PF16492.3 001198669.1_29626001_1 - 9.2e-06 26.2 0.2 3.4e-05 24.4 0.2 2.0 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001198669.1_29626001_1 - 0.00032 20.5 1.6 10 6.1 0.0 4.6 5 0 0 5 5 5 2 Cadherin-like Orn_Arg_deC_N PF02784.14 001291699.1_09029001_2 - 2.5e-63 213.7 0.1 3.2e-63 213.3 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001291699.1_09029001_2 - 8.5e-24 83.7 0.0 1.5e-23 82.9 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain RIIa PF02197.15 001256771.3_49824001_3 - 9.5e-12 44.3 0.4 1.3e-09 37.4 0.0 2.4 2 0 0 2 2 2 2 Regulatory subunit of type II PKA R-subunit SMN PF06003.10 001256771.3_49824001_3 - 1 8.4 8.6 0.87 8.7 6.9 1.6 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) zf-H2C2_2 PF13465.4 037801.1_26224120_2 - 1.4e-55 183.2 73.9 4.9e-09 36.1 1.7 10.0 9 1 0 9 9 9 9 Zinc-finger double domain zf-C2H2 PF00096.24 037801.1_26224120_2 - 7e-23 79.6 80.2 1.3e-05 25.3 2.1 10.1 10 0 0 10 10 10 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 037801.1_26224120_2 - 5.7e-21 73.3 76.1 0.0027 18.3 1.0 10.0 10 0 0 10 10 10 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 037801.1_26224120_2 - 7.5e-15 54.3 63.8 0.0013 18.5 1.9 9.6 10 0 0 10 10 10 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 037801.1_26224120_2 - 0.0012 18.9 49.1 0.38 11.0 0.1 8.0 9 0 0 9 9 7 4 Zinc-finger double-stranded RNA-binding zf-trcl PF13451.4 037801.1_26224120_2 - 0.07 12.9 29.8 6.9 6.5 4.4 7.6 7 1 0 7 7 7 0 Probable zinc-ribbon domain XPA_N PF01286.16 037801.1_26224120_2 - 0.077 12.9 38.0 2.6 8.0 1.3 8.1 8 0 0 8 8 8 0 XPA protein N-terminal Zn-ribbon_8 PF09723.8 037801.1_26224120_2 - 0.49 10.4 55.9 0.55 10.3 5.8 7.2 3 2 5 8 8 7 0 Zinc ribbon domain zf-C2H2_11 PF16622.3 037801.1_26224120_2 - 1.1 9.0 49.7 0.056 13.1 1.3 8.5 9 0 0 9 9 9 0 zinc-finger C2H2-type DUF3268 PF11672.6 037801.1_26224120_2 - 1.4 9.2 33.6 0.087 13.0 1.9 4.7 2 2 5 7 7 7 0 zinc-finger-containing domain C1_4 PF07975.10 037801.1_26224120_2 - 2.8 8.1 38.0 0.38 10.9 3.3 6.0 1 1 7 8 8 8 0 TFIIH C1-like domain KRAB PF01352.25 037801.1_26224120_3 - 3e-22 77.9 1.3 6.2e-22 76.9 1.3 1.5 1 0 0 1 1 1 1 KRAB box 4_1_CTD PF05902.11 146620.1_26226120_1 - 8.1e-31 106.2 1.5 1.3e-30 105.6 1.5 1.2 1 0 0 1 1 1 1 4.1 protein C-terminal domain (CTD) FERM_C PF09380.8 146620.1_26226120_1 - 6.8e-24 83.9 0.0 1.3e-23 83.1 0.0 1.4 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FA PF08736.9 146620.1_26226120_1 - 5.7e-19 67.8 5.0 1.5e-18 66.5 5.0 1.8 1 0 0 1 1 1 1 FERM adjacent (FA) FERM_M PF00373.16 146620.1_26226120_1 - 8.7e-19 67.9 0.0 1.6e-18 67.1 0.0 1.4 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.8 146620.1_26226120_1 - 2.5e-15 56.0 0.0 6.9e-15 54.6 0.0 1.8 1 0 0 1 1 1 1 FERM N-terminal domain C2 PF00168.28 145711.1_26229120_2 - 5.6e-15 55.4 0.0 8.8e-15 54.7 0.0 1.3 1 0 0 1 1 1 1 C2 domain C2 PF00168.28 145711.1_26229120_3 - 2.1e-19 69.6 0.0 3.9e-19 68.7 0.0 1.5 1 0 0 1 1 1 1 C2 domain PDZ PF00595.22 145711.1_26229120_3 - 1.1e-05 25.5 0.0 2e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Sec1 PF00995.21 073560.1_26224120_1 - 3.4e-19 69.3 0.0 4.2e-19 69.1 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Sec1 PF00995.21 073560.1_26224120_2 - 8.9e-84 282.6 0.5 2.6e-81 274.4 0.2 2.0 1 1 1 2 2 2 2 Sec1 family HBM PF16591.3 073560.1_26224120_2 - 0.11 11.7 0.2 0.27 10.5 0.2 1.6 1 0 0 1 1 1 0 Helical bimodular sensor domain DASH_Hsk3 PF08227.9 073560.1_26224120_2 - 0.2 11.9 0.5 0.64 10.3 0.1 2.0 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like TMEM51 PF15345.4 104250.1_26224120_2 - 0.0014 18.4 6.7 0.0027 17.5 6.7 1.4 1 1 0 1 1 1 1 Transmembrane protein 51 CI-B14_5a PF07347.10 103515.1_32922120_2 - 0.00076 19.2 0.1 0.0011 18.7 0.1 1.2 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) Lustrin_cystein PF14625.4 103515.1_32922120_3 - 0.094 13.0 1.3 2.5 8.4 0.1 2.3 2 0 0 2 2 2 0 Lustrin, cysteine-rich repeated domain zf-DHHC PF01529.18 148714.1_26229120_2 - 3.2e-27 95.1 15.7 3.2e-27 95.1 15.7 5.3 7 1 0 7 7 7 1 DHHC palmitoyltransferase Kelch_3 PF13415.4 033386.1_26223120_2 - 2.4e-08 33.9 11.4 0.00061 19.9 1.4 4.3 4 1 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.23 033386.1_26223120_2 - 0.00069 19.0 0.0 0.016 14.7 0.1 2.9 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.4 033386.1_26223120_2 - 0.027 14.6 0.1 0.22 11.7 0.1 2.4 2 0 0 2 2 2 0 Kelch motif Nbas_N PF15492.4 033386.1_26223120_2 - 0.031 13.5 0.1 0.047 12.9 0.1 1.2 1 0 0 1 1 1 0 Neuroblastoma-amplified sequence, N terminal Kelch_5 PF13854.4 033386.1_26223120_3 - 1e-07 31.6 0.1 0.00071 19.4 0.0 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.4 033386.1_26223120_3 - 1.3e-07 31.4 0.2 0.0057 16.4 0.0 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_3 PF13415.4 033386.1_26223120_3 - 1.6e-06 28.1 2.3 0.0042 17.2 0.1 3.2 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.4 033386.1_26223120_3 - 2.1e-05 24.5 0.1 0.023 14.8 0.0 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.13 033386.1_26223120_3 - 0.00088 19.0 0.3 0.022 14.6 0.0 2.6 2 1 0 2 2 2 1 Kelch motif Kelch_1 PF01344.23 033386.1_26223120_3 - 0.052 13.0 0.0 4.1 6.9 0.0 2.5 2 0 0 2 2 2 0 Kelch motif Cep57_CLD PF14073.4 146889.1_26225120_3 - 1.2e-63 214.3 38.6 1.7e-63 213.7 38.6 1.3 1 0 0 1 1 1 1 Centrosome localisation domain of Cep57 Cu-oxidase_3 PF07732.13 046371.1_26228120_2 - 2.1e-23 82.5 4.2 2.9e-08 33.6 0.0 5.2 4 2 0 4 4 4 3 Multicopper oxidase Cu-oxidase_2 PF07731.12 046371.1_26228120_2 - 1.5e-16 60.3 5.6 3.5e-05 23.4 0.0 5.0 5 0 0 5 5 5 4 Multicopper oxidase Cu-oxidase PF00394.20 046371.1_26228120_2 - 6.8e-16 58.7 0.8 2.6e-11 43.7 0.0 2.9 3 0 0 3 3 3 2 Multicopper oxidase Rep_fac-A_C PF08646.8 001080995.2_32927001_1 - 8.7e-11 41.6 0.0 2.3e-10 40.3 0.0 1.7 1 0 0 1 1 1 1 Replication factor-A C terminal domain HypA PF01155.17 001080995.2_32927001_1 - 0.52 10.2 2.4 0.5 10.3 0.1 2.1 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.5 001080995.2_32927001_1 - 3.1 7.8 7.0 1.6 8.7 0.7 3.3 3 0 0 3 3 3 0 Double zinc ribbon Zn_Tnp_IS1595 PF12760.5 001080995.2_32927001_1 - 3.6 7.5 9.3 0.47 10.3 0.3 3.6 4 0 0 4 4 4 0 Transposase zinc-ribbon domain ICAM_N PF03921.12 001194939.1_39722001_1 - 5.7e-16 57.8 0.0 8.6e-16 57.3 0.0 1.2 1 0 0 1 1 1 1 Intercellular adhesion molecule (ICAM), N-terminal domain Hepcidin PF06446.10 183257.4_32921001_2 - 6.6e-18 64.7 10.9 1.2e-17 63.8 10.9 1.5 1 0 0 1 1 1 1 Hepcidin Ribosomal_L7Ae PF01248.24 001287722.1_29521001_3 - 6.9e-26 89.7 0.1 8.7e-26 89.4 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Hydrolase_6 PF13344.4 001287722.1_29521001_3 - 0.06 13.3 0.0 0.088 12.8 0.0 1.2 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Apo-CIII PF05778.10 001172915.1_09922001_1 - 1.1e-33 114.5 1.1 1.5e-33 114.1 1.1 1.1 1 0 0 1 1 1 1 Apolipoprotein CIII (Apo-CIII) ApoC-I PF04691.10 001172915.1_09922001_1 - 0.007 16.1 0.4 0.014 15.2 0.3 1.5 1 1 1 2 2 2 1 Apolipoprotein C-I (ApoC-1) Pkinase PF00069.23 213919.2_49823001_2 - 5.5e-70 235.6 0.0 6.6e-70 235.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 213919.2_49823001_2 - 1.6e-41 142.2 0.0 2e-41 141.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 213919.2_49823001_2 - 0.0009 18.5 0.0 0.0028 16.9 0.0 1.8 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.12 213919.2_49823001_2 - 0.065 12.5 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family 7tm_1 PF00001.19 001102661.2_39726001_1 - 2.5e-52 177.6 15.6 4.8e-52 176.7 15.6 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TrbC PF04956.11 001102661.2_39726001_1 - 0.19 11.9 1.9 5.8 7.1 0.2 2.4 2 0 0 2 2 2 0 TrbC/VIRB2 family Amelogenin PF02948.13 001102459.1_39722001_3 - 1.7e-68 230.5 48.2 2.1e-68 230.2 48.2 1.1 1 0 0 1 1 1 1 Amelogenin TFIIA PF03153.11 001102459.1_39722001_3 - 2.1 8.1 5.4 2.3 8.0 5.4 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit p450 PF00067.20 001310560.1_31324001_2 - 9.8e-139 462.9 0.0 1.1e-138 462.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Hormone_5 PF00184.15 001009801.2_39522001_1 - 1.7e-31 108.8 22.6 1.7e-31 108.8 22.6 1.7 2 0 0 2 2 2 1 Neurohypophysial hormones, C-terminal Domain Hormone_4 PF00220.15 001009801.2_39522001_1 - 0.0003 20.3 3.9 0.0011 18.6 3.9 2.1 1 0 0 1 1 1 1 Neurohypophysial hormones, N-terminal Domain V1R PF03402.12 001167544.1_39722001_1 - 4e-23 82.2 10.9 6.9e-23 81.5 10.9 1.3 1 1 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R AbLIM_anchor PF16182.3 001323388.1_26225001_2 - 5.8e-80 269.8 9.0 1.7e-59 202.4 4.8 2.1 1 1 1 2 2 2 2 Putative adherens-junction anchoring region of AbLIM VHP PF02209.17 001323388.1_26225001_2 - 1.1e-14 54.1 0.8 2.1e-14 53.1 0.8 1.5 1 0 0 1 1 1 1 Villin headpiece domain STAT1_TAZ2bind PF12162.6 001323388.1_26225001_2 - 0.047 13.1 0.8 6.1 6.4 0.0 2.6 2 0 0 2 2 2 0 STAT1 TAZ2 binding domain Globin PF00042.20 001135832.1_39721001_1 - 8.2e-31 106.7 0.1 3.3e-30 104.8 0.0 1.8 2 0 0 2 2 2 1 Globin 7tm_1 PF00001.19 022983.4_32925001_2 - 1.5e-35 122.6 22.4 2.2e-35 122.0 22.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 022983.4_32925001_2 - 4.3e-05 23.3 16.2 0.00012 21.8 16.2 1.7 1 1 0 1 1 1 1 Olfactory receptor Globin PF00042.20 001168816.2_40422001_3 - 5e-28 97.7 0.5 7.1e-28 97.2 0.5 1.2 1 0 0 1 1 1 1 Globin Pou PF00157.15 001252041.1_39723001_2 - 4.1e-38 129.1 1.1 7.7e-38 128.2 1.1 1.5 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 001252041.1_39723001_2 - 1e-18 66.8 0.6 2e-18 65.8 0.6 1.5 1 0 0 1 1 1 1 Homeobox domain DUF521 PF04412.11 001252041.1_39723001_2 - 0.052 12.1 0.3 0.13 10.8 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF521) MFS_1 PF07690.14 176080.2_45725001_3 - 3.3e-15 55.7 58.5 4.7e-11 42.1 31.8 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily TrkH PF02386.14 176080.2_45725001_3 - 0.00014 20.3 0.1 0.00023 19.6 0.1 1.3 1 0 0 1 1 1 1 Cation transport protein MFS_4 PF06779.12 176080.2_45725001_3 - 0.64 9.1 26.7 1.9 7.5 6.8 2.5 2 1 0 2 2 2 0 Uncharacterised MFS-type transporter YbfB HCO3_cotransp PF00955.19 001030533.1_49827001_3 - 7.5e-231 767.3 9.2 9.6e-231 766.9 9.2 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 001030533.1_49827001_3 - 4e-100 334.9 0.1 7.6e-100 334.0 0.1 1.5 1 0 0 1 1 1 1 Band 3 cytoplasmic domain PTS_EIIA_2 PF00359.20 001030533.1_49827001_3 - 0.00045 20.0 0.0 0.0033 17.2 0.0 2.1 2 0 0 2 2 2 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 Fmp27_WPPW PF10359.7 001030533.1_49827001_3 - 0.026 13.3 0.4 0.061 12.0 0.0 1.7 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain VWA_N PF08399.9 001030533.1_49827001_3 - 0.059 13.7 0.6 0.48 10.8 0.1 2.2 2 0 0 2 2 2 0 VWA N-terminal COX17 PF05051.11 001348525.1_49821001_2 - 5.3e-21 74.6 6.8 8.4e-21 73.9 6.8 1.3 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) 7tm_1 PF00001.19 001195269.2_39727001_3 - 6.3e-71 238.6 8.4 9.4e-71 238.0 8.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TFIIS_M PF07500.12 198723.2_26224001_2 - 2.7e-41 140.3 1.2 4.9e-41 139.5 1.2 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.16 198723.2_26224001_2 - 9.1e-18 63.7 8.1 1.9e-17 62.7 8.1 1.6 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.9 198723.2_26224001_2 - 7.1e-14 51.4 1.1 1.5e-13 50.4 1.1 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Gp_dh_C PF02800.18 001190390.1_39523001_1 - 5.9e-70 233.8 0.0 9.6e-70 233.1 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.22 001190390.1_39523001_1 - 2.2e-39 133.7 0.4 4.8e-39 132.7 0.3 1.6 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.18 001190390.1_39523001_1 - 0.065 13.2 0.1 0.18 11.8 0.1 1.8 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Uteroglobin PF01099.15 001082237.1_37921001_3 - 9.3e-22 76.9 0.1 1.2e-21 76.5 0.1 1.2 1 0 0 1 1 1 1 Uteroglobin family I-set PF07679.14 016081.3_26229001_2 - 2.1e-111 364.1 0.0 8.6e-24 83.3 0.0 5.3 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.4 016081.3_26229001_2 - 4.3e-76 251.4 0.0 5.4e-14 52.4 0.0 5.6 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.4 016081.3_26229001_2 - 1.6e-52 175.6 0.2 4.2e-10 39.7 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.23 016081.3_26229001_2 - 1.1e-50 169.6 0.9 4.6e-10 39.4 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain V-set PF07686.15 016081.3_26229001_2 - 4e-22 78.3 1.8 0.00083 19.4 0.0 7.9 5 2 0 5 5 5 5 Immunoglobulin V-set domain C2-set_2 PF08205.10 016081.3_26229001_2 - 1.5e-17 63.3 0.1 0.046 13.7 0.0 5.8 5 0 0 5 5 5 5 CD80-like C2-set immunoglobulin domain C1-set PF07654.13 016081.3_26229001_2 - 1.1e-07 32.1 0.2 4.8 7.6 0.0 5.3 5 0 0 5 5 5 3 Immunoglobulin C1-set domain Receptor_2B4 PF11465.6 016081.3_26229001_2 - 0.00097 19.2 0.0 0.2 11.8 0.0 3.8 4 0 0 4 4 4 1 Natural killer cell receptor 2B4 Phospholamban PF04272.12 001082621.2_37922001_2 - 4.9e-35 118.7 10.4 7.9e-35 118.0 10.4 1.4 1 0 0 1 1 1 1 Phospholamban Insulin PF00049.16 001172891.1_09921001_1 - 2.8e-23 82.6 1.1 3.5e-23 82.3 1.1 1.1 1 0 0 1 1 1 1 Insulin/IGF/Relaxin family Ins_beta PF03488.12 001172891.1_09921001_1 - 0.0039 17.0 3.7 0.51 10.3 1.4 2.2 2 0 0 2 2 2 2 Nematode insulin-related peptide beta type HCO3_cotransp PF00955.19 001082060.1_37928001_1 - 6.9e-231 767.4 7.9 9.1e-231 767.0 7.9 1.2 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 001082060.1_37928001_1 - 3.9e-100 334.9 1.2 9.2e-100 333.7 0.1 2.1 2 0 0 2 2 2 1 Band 3 cytoplasmic domain PTS_EIIA_2 PF00359.20 001082060.1_37928001_1 - 0.00056 19.7 0.0 0.0048 16.7 0.0 2.2 2 0 0 2 2 2 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 Fmp27_WPPW PF10359.7 001082060.1_37928001_1 - 0.023 13.5 0.6 0.056 12.2 0.1 1.9 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain NO_synthase PF02898.13 001082733.1_37928001_1 - 9.7e-181 600.5 0.0 1.3e-180 600.1 0.0 1.1 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain FAD_binding_1 PF00667.18 001082733.1_37928001_1 - 1.6e-80 269.7 0.0 2.4e-80 269.2 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.23 001082733.1_37928001_1 - 3.4e-52 176.3 0.0 5.6e-52 175.6 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.19 001082733.1_37928001_1 - 1.7e-19 70.3 0.0 9.2e-19 68.0 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain HTH_15 PF12324.6 001082733.1_37928001_1 - 0.042 13.6 0.2 0.12 12.2 0.2 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain of alkylmercury lyase CaKB PF03185.13 001082225.1_37923001_1 - 6.2e-62 208.6 0.9 7.9e-62 208.3 0.9 1.1 1 0 0 1 1 1 1 Calcium-activated potassium channel, beta subunit EF-hand_1 PF00036.30 001009759.1_39522001_3 - 6.1e-43 141.1 9.6 6.7e-10 37.7 0.4 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 001009759.1_39522001_3 - 2.6e-36 123.8 2.7 9.7e-19 67.5 0.7 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 001009759.1_39522001_3 - 2e-34 117.0 9.8 2e-15 56.1 0.3 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.4 001009759.1_39522001_3 - 4.7e-31 103.9 4.8 1.7e-09 36.7 0.1 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.4 001009759.1_39522001_3 - 2.7e-27 92.9 6.9 1.4e-06 27.4 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.4 001009759.1_39522001_3 - 2.5e-15 56.4 0.2 4.2e-09 36.5 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 001009759.1_39522001_3 - 7.2e-10 38.6 0.3 9.6e-05 22.2 0.1 2.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 001009759.1_39522001_3 - 8.2e-08 32.4 0.0 0.0072 16.5 0.0 2.2 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.9 001009759.1_39522001_3 - 6.2e-06 26.9 0.0 0.0016 19.1 0.0 2.1 1 1 1 2 2 2 1 EF-hand domain UPF0154 PF03672.11 001009759.1_39522001_3 - 3.7e-05 23.5 0.0 0.065 13.1 0.0 3.0 2 1 1 3 3 3 1 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.8 001009759.1_39522001_3 - 4.7e-05 23.3 1.1 0.00015 21.6 0.1 2.2 2 1 0 2 2 2 1 Ca2+ insensitive EF hand DUF4497 PF14924.4 001009759.1_39522001_3 - 0.00098 19.4 0.0 1.4 9.2 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF4497) DUF3349 PF11829.6 001009759.1_39522001_3 - 0.0024 18.5 0.4 1.9 9.2 0.0 2.8 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) Caleosin PF05042.11 001009759.1_39522001_3 - 0.0029 17.4 0.7 0.5 10.1 0.3 3.4 1 1 1 2 2 2 1 Caleosin related protein DUF1103 PF06513.9 001009759.1_39522001_3 - 0.0032 17.0 2.5 0.0039 16.7 2.5 1.2 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) TerB PF05099.11 001009759.1_39522001_3 - 0.0071 16.2 0.8 1.1 9.0 0.0 2.3 1 1 1 2 2 2 1 Tellurite resistance protein TerB RNA_pol_Rpb4 PF03874.14 001009759.1_39522001_3 - 0.0072 16.5 0.6 2.5 8.3 0.1 2.6 3 0 0 3 3 2 1 RNA polymerase Rpb4 GPHH PF16905.3 001009759.1_39522001_3 - 0.017 14.8 0.0 0.25 11.0 0.0 2.7 3 1 1 4 4 4 0 Voltage-dependent L-type calcium channel, IQ-associated DUF2267 PF10025.7 001009759.1_39522001_3 - 0.021 15.0 0.0 0.08 13.1 0.0 1.8 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2267) SurA_N_2 PF13623.4 001009759.1_39522001_3 - 0.022 14.5 0.9 0.76 9.5 0.2 2.2 1 1 1 2 2 2 0 SurA N-terminal domain Poly_export PF02563.14 001009759.1_39522001_3 - 0.039 14.0 0.1 1.5 9.0 0.0 2.8 1 1 2 3 3 3 0 Polysaccharide biosynthesis/export protein MotA_activ PF09114.8 001009759.1_39522001_3 - 0.1 12.6 0.0 1.5 8.9 0.0 2.3 2 0 0 2 2 2 0 Transcription factor MotA, activation domain SurA_N_3 PF13624.4 001009759.1_39522001_3 - 0.14 11.8 0.6 1.1 8.8 0.2 2.0 1 1 1 2 2 2 0 SurA N-terminal domain PDZ PF00595.22 001082107.1_37924001_2 - 3.4e-34 116.9 0.0 8.6e-16 57.9 0.0 2.2 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) EBP50_C PF09007.9 001082107.1_37924001_2 - 5.7e-28 98.4 4.9 2.4e-17 64.0 1.3 2.9 1 1 1 2 2 2 2 EBP50, C-terminal PDZ_2 PF13180.4 001082107.1_37924001_2 - 5.4e-14 52.1 0.0 1e-05 25.6 0.0 2.3 2 0 0 2 2 2 2 PDZ domain GRASP55_65 PF04495.12 001082107.1_37924001_2 - 0.00052 20.2 0.0 0.75 10.0 0.0 2.2 2 0 0 2 2 2 2 GRASP55/65 PDZ-like domain DUF1450 PF07293.9 001082107.1_37924001_2 - 0.014 15.0 1.1 1.1 9.0 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1450) DUF3915 PF13054.4 001082107.1_37924001_2 - 1.6 8.6 3.3 3.1 7.7 3.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) 7tm_1 PF00001.19 001287319.1_29523001_1 - 2.3e-37 128.6 15.9 2.9e-37 128.2 15.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) APOBEC_N PF08210.9 001009001.2_39724001_2 - 2.1e-84 281.7 10.6 3.6e-44 150.7 3.2 2.1 2 0 0 2 2 2 2 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001009001.2_39724001_2 - 3e-64 212.8 0.3 1.1e-31 108.4 0.0 2.6 2 0 0 2 2 2 2 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 001009001.2_39724001_2 - 0.018 14.8 0.1 8.2 6.2 0.0 2.3 2 0 0 2 2 2 0 Cytidine and deoxycytidylate deaminase zinc-binding region Pox_A3L PF05288.9 001009001.2_39724001_2 - 0.058 13.3 0.6 0.98 9.3 0.0 2.5 2 0 0 2 2 2 0 Poxvirus A3L Protein Toxin-deaminase PF14424.4 001009001.2_39724001_2 - 0.08 12.9 0.5 1.7 8.6 0.3 2.2 2 0 0 2 2 2 0 The BURPS668_1122 family of deaminases NODP PF07684.10 001009001.2_39724001_2 - 0.44 10.6 3.0 0.58 10.2 0.9 2.1 2 0 0 2 2 2 0 NOTCH protein 14-3-3 PF00244.18 001267887.1_39522001_1 - 3.1e-109 363.5 7.7 3.5e-109 363.4 7.7 1.0 1 0 0 1 1 1 1 14-3-3 protein Peptidase_C98 PF15499.4 001267887.1_39522001_1 - 0.061 12.6 0.2 0.1 11.9 0.2 1.4 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase FliM PF02154.13 001267887.1_39522001_1 - 0.066 12.9 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 Flagellar motor switch protein FliM Kringle PF00051.16 001044590.2_49826001_2 - 1.2e-150 490.0 66.1 4.6e-31 106.8 9.8 5.4 5 0 0 5 5 5 5 Kringle domain Trypsin PF00089.24 001044590.2_49826001_2 - 3.4e-64 216.6 0.0 6.2e-64 215.7 0.0 1.5 1 0 0 1 1 1 1 Trypsin PAN_1 PF00024.24 001044590.2_49826001_2 - 5.8e-14 51.7 0.9 2.4e-13 49.7 0.9 2.1 1 0 0 1 1 1 1 PAN domain DUF1986 PF09342.9 001044590.2_49826001_2 - 1.2e-07 32.0 0.0 2.7e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 001044590.2_49826001_2 - 6.7e-06 26.9 0.0 1.4e-05 25.9 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain PAN_2 PF08276.9 001044590.2_49826001_2 - 0.099 12.6 9.2 0.059 13.3 1.0 2.9 2 0 0 2 2 2 0 PAN-like domain DUF3719 PF12516.6 001044590.2_49826001_2 - 0.21 11.2 0.1 0.21 11.2 0.1 4.5 5 0 0 5 5 5 0 Protein of unknown function (DUF3719) 7tm_1 PF00001.19 001071793.2_39725001_1 - 1.8e-50 171.5 22.7 3.3e-50 170.7 22.7 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001071793.2_39725001_1 - 3.9e-07 29.6 22.0 3.9e-07 29.6 22.0 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx Pkinase PF00069.23 008778.3_32929001_2 - 1.4e-71 240.9 0.0 1.8e-71 240.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 008778.3_32929001_2 - 1.2e-44 152.5 0.0 1.8e-44 151.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 008778.3_32929001_2 - 1.1e-22 80.0 0.0 2e-22 79.2 0.0 1.5 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 008778.3_32929001_2 - 1e-05 24.9 0.0 0.0022 17.2 0.0 2.3 1 1 1 2 2 2 2 Kinase-like Spt5_N PF11942.6 008778.3_32929001_2 - 0.036 14.9 2.6 0.076 13.9 2.6 1.4 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal APH PF01636.21 008778.3_32929001_2 - 0.13 12.0 0.1 0.4 10.4 0.1 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family DSHCT PF08148.10 008778.3_32929001_2 - 0.13 11.7 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 DSHCT (NUC185) domain Ribosomal_60s PF00428.17 008778.3_32929001_2 - 0.27 11.7 2.2 0.64 10.5 2.2 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein ASCH PF04266.12 001324274.1_26225001_3 - 0.014 15.9 0.0 0.02 15.3 0.0 1.2 1 0 0 1 1 1 0 ASCH domain zf-H2C2_2 PF13465.4 001195266.2_39729001_3 - 5.3e-67 219.3 50.1 4.3e-08 33.1 0.1 10.9 11 0 0 11 11 10 9 Zinc-finger double domain zf-C2H2 PF00096.24 001195266.2_39729001_3 - 3.8e-54 178.1 49.5 4.3e-06 26.7 0.3 9.9 9 0 0 9 9 9 9 Zinc finger, C2H2 type SCAN PF02023.15 001195266.2_39729001_3 - 4.4e-37 125.6 5.8 8.7e-37 124.7 5.8 1.4 1 0 0 1 1 1 1 SCAN domain zf-C2H2_4 PF13894.4 001195266.2_39729001_3 - 3.5e-29 98.8 48.7 0.0032 18.0 0.7 10.2 9 0 0 9 9 9 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001195266.2_39729001_3 - 6.7e-19 67.3 44.3 0.00016 21.4 1.0 9.6 9 0 0 9 9 9 8 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001195266.2_39729001_3 - 3.3e-11 43.0 33.0 0.0068 16.4 1.4 6.0 4 2 2 6 6 6 5 Zinc ribbon domain KRAB PF01352.25 001195266.2_39729001_3 - 1.2e-08 34.3 0.0 2.4e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 KRAB box C1_1 PF00130.20 001195266.2_39729001_3 - 7.8e-06 25.6 22.0 0.6 9.9 0.7 6.3 2 2 3 6 6 6 4 Phorbol esters/diacylglycerol binding domain (C1 domain) XPA_N PF01286.16 001195266.2_39729001_3 - 1.3e-05 25.0 33.7 0.78 9.7 0.3 9.0 9 0 0 9 9 9 2 XPA protein N-terminal zinc_ribbon_15 PF17032.3 001195266.2_39729001_3 - 7.1e-05 23.3 27.0 1.5 9.5 4.8 5.2 2 2 3 5 5 5 4 zinc-ribbon family DZR PF12773.5 001195266.2_39729001_3 - 0.00012 21.8 31.9 2.8 7.9 6.6 5.1 1 1 2 3 3 3 2 Double zinc ribbon FYVE PF01363.19 001195266.2_39729001_3 - 0.00026 20.9 33.2 0.018 15.1 2.2 5.4 1 1 3 4 4 4 2 FYVE zinc finger zf-C2H2_11 PF16622.3 001195266.2_39729001_3 - 0.00028 20.4 41.2 0.31 10.7 0.4 8.9 9 0 0 9 9 9 4 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 001195266.2_39729001_3 - 0.00045 20.3 21.4 0.14 12.3 0.1 7.5 8 0 0 8 8 8 2 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.3 001195266.2_39729001_3 - 0.0012 18.9 20.1 0.1 12.8 0.3 5.2 1 1 5 6 6 6 3 C2H2-type zinc ribbon SPX PF03105.17 001195266.2_39729001_3 - 0.0013 18.6 1.2 0.0019 18.1 1.2 1.1 1 0 0 1 1 1 1 SPX domain zf-met PF12874.5 001195266.2_39729001_3 - 0.1 12.9 43.2 0.1 12.9 0.9 8.0 8 0 0 8 8 8 0 Zinc-finger of C2H2 type ADK_lid PF05191.12 001195266.2_39729001_3 - 0.74 9.8 24.7 0.37 10.7 0.7 5.8 4 2 2 6 6 6 0 Adenylate kinase, active site lid Prion PF00377.16 001009093.4_39726001_1 - 9.2e-35 118.9 2.2 1.4e-34 118.3 2.2 1.3 1 0 0 1 1 1 1 Prion/Doppel alpha-helical domain Prion_bPrPp PF11587.6 001009093.4_39726001_1 - 7e-17 60.8 4.0 1.5e-16 59.8 4.0 1.6 1 0 0 1 1 1 1 Major prion protein bPrPp - N terminal PRIMA1 PF16101.3 001009093.4_39726001_1 - 1.7 8.6 5.2 3.6 7.5 5.2 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Metal_CEHH PF14455.4 001009093.4_39726001_3 - 1.8 8.0 4.1 2.9 7.3 0.3 2.1 2 0 0 2 2 2 0 Predicted metal binding domain Transferrin PF00405.15 001101694.1_37925001_1 - 1.4e-247 819.7 8.3 1.2e-166 553.7 0.1 2.1 2 0 0 2 2 2 2 Transferrin Phosphonate-bd PF12974.5 001101694.1_37925001_1 - 3.7e-10 39.7 0.0 0.00039 20.0 0.0 3.0 3 1 0 3 3 3 2 ABC transporter, phosphonate, periplasmic substrate-binding protein Trypsin PF00089.24 001009377.3_22423001_1 - 6e-69 232.1 0.4 8.3e-69 231.6 0.4 1.2 1 0 0 1 1 1 1 Trypsin Gla PF00594.18 001009377.3_22423001_1 - 3.5e-21 75.0 12.1 6.9e-21 74.0 12.1 1.5 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FXa_inhibition PF14670.4 001009377.3_22423001_1 - 7.9e-09 35.5 7.9 7.9e-09 35.5 7.9 3.2 4 0 0 4 4 4 2 Coagulation Factor Xa inhibitory site EGF PF00008.25 001009377.3_22423001_1 - 6.5e-08 32.6 18.0 1.9e-07 31.1 7.2 2.9 2 0 0 2 2 2 2 EGF-like domain Trypsin_2 PF13365.4 001009377.3_22423001_1 - 1.1e-05 26.2 0.1 2.1e-05 25.3 0.1 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001009377.3_22423001_1 - 1.4e-05 25.3 0.1 3.1e-05 24.2 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) cEGF PF12662.5 001009377.3_22423001_1 - 0.00081 19.1 12.1 0.0015 18.3 0.7 3.2 3 0 0 3 3 3 2 Complement Clr-like EGF-like hEGF PF12661.5 001009377.3_22423001_1 - 0.0079 16.7 13.2 0.0085 16.6 4.7 3.7 2 1 0 2 2 2 1 Human growth factor-like EGF EGF_3 PF12947.5 001009377.3_22423001_1 - 0.55 10.3 17.6 2.2 8.4 4.2 3.0 1 1 1 2 2 2 0 EGF domain EGF_2 PF07974.11 001009377.3_22423001_1 - 2.4 8.5 24.9 0.97 9.7 11.7 3.2 2 0 0 2 2 2 0 EGF-like domain EGF_CA PF07645.13 001009377.3_22423001_1 - 4.4 7.5 23.0 19 5.4 15.0 3.3 2 1 0 2 2 2 0 Calcium-binding EGF domain Na_sulph_symp PF00939.17 001177592.1_37925001_2 - 1.3e-156 522.2 20.7 1.5e-156 522.0 20.7 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.14 001177592.1_37925001_2 - 6e-36 124.1 24.1 8e-21 74.4 0.0 3.1 2 1 1 3 3 3 2 Citrate transporter Ribosomal_L1 PF00687.19 001097477.2_49822001_2 - 1.4e-43 148.9 4.3 1.8e-43 148.5 4.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Homeobox PF00046.27 001195262.2_39724001_2 - 9.3e-21 73.3 4.6 1.5e-20 72.6 4.6 1.4 1 0 0 1 1 1 1 Homeobox domain Cadherin PF00028.15 001082584.2_39729001_1 - 1.5e-73 243.2 0.0 7.1e-18 64.7 0.0 6.4 6 0 0 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 001082584.2_39729001_1 - 2.1e-63 212.4 4.7 3.6e-63 211.7 4.7 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 001082584.2_39729001_1 - 9.9e-31 105.3 0.1 7.8e-28 96.0 0.1 3.9 4 0 0 4 4 4 1 Cadherin-like Cadherin_C_2 PF16492.3 001082584.2_39729001_1 - 1.8e-05 25.3 0.2 9.8e-05 22.9 0.2 2.3 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001082584.2_39729001_1 - 1.8e-05 24.6 2.5 1.8 8.5 0.0 4.5 4 0 0 4 4 4 2 Cadherin-like DUF4958 PF16319.3 001082584.2_39729001_1 - 0.0074 14.3 0.0 0.012 13.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4958) COX6C PF02937.13 001097473.2_49821001_3 - 2.4e-39 133.1 0.9 3.9e-39 132.5 0.9 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIc Pkinase PF00069.23 001082042.2_37925001_1 - 5.9e-71 238.8 0.0 1.2e-70 237.8 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain cNMP_binding PF00027.27 001082042.2_37925001_1 - 1.4e-36 124.2 0.0 6e-17 61.3 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.15 001082042.2_37925001_1 - 1.2e-35 122.9 0.0 2.5e-35 121.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase PKcGMP_CC PF16808.3 001082042.2_37925001_1 - 6.2e-15 54.6 16.9 1.2e-14 53.7 16.9 1.5 1 0 0 1 1 1 1 Coiled-coil N-terminus of cGMP-dependent protein kinase Kinase-like PF14531.4 001082042.2_37925001_1 - 6.5e-05 22.2 0.0 0.00011 21.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Wtap PF17098.3 001082042.2_37925001_1 - 0.0067 16.3 0.4 0.013 15.3 0.4 1.5 1 0 0 1 1 1 1 WTAP/Mum2p family Pkinase_C PF00433.22 001082042.2_37925001_1 - 0.02 15.4 1.6 0.05 14.2 1.6 1.7 1 0 0 1 1 1 0 Protein kinase C terminal domain APH PF01636.21 001082042.2_37925001_1 - 0.027 14.3 0.0 0.23 11.2 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Atg14 PF10186.7 001082042.2_37925001_1 - 0.041 12.8 0.7 0.072 12.0 0.7 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Med4 PF10018.7 001082042.2_37925001_1 - 0.087 12.4 0.5 0.21 11.1 0.5 1.6 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 IncA PF04156.12 001082042.2_37925001_1 - 0.19 11.4 1.8 0.41 10.3 1.8 1.6 1 0 0 1 1 1 0 IncA protein DUF641 PF04859.10 001082042.2_37925001_1 - 0.97 9.6 6.4 0.4 10.9 3.4 1.9 2 0 0 2 2 1 0 Plant protein of unknown function (DUF641) TPD52 PF04201.13 001082042.2_37925001_1 - 2.1 7.8 4.6 18 4.8 5.6 2.1 2 0 0 2 2 2 0 Tumour protein D52 family SlyX PF04102.10 001082042.2_37925001_1 - 2.4 8.7 4.6 0.38 11.3 0.2 1.9 2 0 0 2 2 1 0 SlyX Pox_A_type_inc PF04508.10 001082042.2_37925001_1 - 8.2 6.3 10.5 8.7 6.2 0.9 2.6 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat FAM72 PF14976.4 001346068.1_26223001_2 - 6e-61 204.7 11.9 8.9e-61 204.1 11.9 1.2 1 0 0 1 1 1 1 FAM72 protein V-set PF07686.15 011197.3_32929001_3 - 1.6e-35 121.4 3.8 4.4e-08 33.1 0.0 6.4 6 0 0 6 6 6 6 Immunoglobulin V-set domain Ig_3 PF13927.4 011197.3_32929001_3 - 3.8e-30 104.2 1.8 3e-05 24.4 0.0 7.3 6 1 0 6 6 6 5 Immunoglobulin domain I-set PF07679.14 011197.3_32929001_3 - 4.3e-20 71.4 0.0 0.00023 21.0 0.0 6.8 6 0 0 6 6 6 5 Immunoglobulin I-set domain ig PF00047.23 011197.3_32929001_3 - 1.9e-18 66.3 9.6 0.0001 22.3 0.0 8.3 7 3 0 7 7 7 4 Immunoglobulin domain Ig_2 PF13895.4 011197.3_32929001_3 - 1.4e-14 54.1 4.0 0.13 12.5 0.0 7.9 6 3 0 6 6 6 4 Immunoglobulin domain Izumo-Ig PF16706.3 011197.3_32929001_3 - 0.00018 21.4 0.8 2.6 8.0 0.0 5.2 6 0 0 6 6 6 1 Izumo-like Immunoglobulin domain dCMP_cyt_deam_1 PF00383.21 138422.3_26224001_1 - 3.3e-14 52.5 0.2 8e-14 51.2 0.2 1.6 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.4 138422.3_26224001_1 - 4.1e-09 36.2 0.0 1.4e-07 31.2 0.0 2.1 2 0 0 2 2 2 1 MafB19-like deaminase Bd3614-deam PF14439.4 138422.3_26224001_1 - 0.00031 20.7 0.2 0.013 15.5 0.0 2.2 2 0 0 2 2 2 1 Bd3614-like deaminase Bombesin PF02044.15 001123145.1_49822001_2 - 8.9e-09 34.7 3.1 1.9e-08 33.7 3.1 1.6 1 0 0 1 1 1 1 Bombesin-like peptide Actin PF00022.17 001009784.2_39524001_3 - 8.2e-151 502.1 0.0 2.1e-150 500.8 0.0 1.6 1 1 0 1 1 1 1 Actin TMEM164 PF14808.4 001353850.1_26226001_2 - 1e-101 339.5 5.0 1.4e-101 339.0 5.0 1.1 1 0 0 1 1 1 1 TMEM164 family SelP_N PF04592.12 001353850.1_26226001_3 - 3.9 6.7 12.3 6 6.1 12.3 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region CHD5 PF04420.12 001350294.1_26223001_1 - 5.6e-32 110.7 1.3 7.4e-32 110.3 1.3 1.1 1 0 0 1 1 1 1 CHD5-like protein DUF1043 PF06295.10 001350294.1_26223001_1 - 0.037 13.9 2.2 0.053 13.4 2.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) DUF2203 PF09969.7 001350294.1_26223001_1 - 0.054 14.1 1.5 1.2 9.8 0.6 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) p450 PF00067.20 001167835.1_49824001_1 - 3.8e-161 536.8 0.0 4.4e-161 536.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Colicin_Pyocin PF01320.16 001167835.1_49824001_1 - 0.14 12.2 0.1 3.7 7.6 0.0 2.5 2 0 0 2 2 2 0 Colicin immunity protein / pyocin immunity protein CLCA PF08434.9 214148.3_49826001_3 - 0 1205.4 0.0 0 1205.2 0.0 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel VWA_2 PF13519.4 214148.3_49826001_3 - 6.1e-11 42.8 0.0 1.6e-10 41.5 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.26 214148.3_49826001_3 - 2.5e-09 37.5 0.0 5.2e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.12 214148.3_49826001_3 - 0.0015 17.8 0.0 0.003 16.9 0.0 1.4 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein SERTA PF06031.11 019605.4_26229001_3 - 3.4e-14 52.1 0.1 3.4e-14 52.1 0.1 1.8 2 0 0 2 2 2 1 SERTA motif Rootletin PF15035.4 001351305.1_26229001_1 - 1.2e-17 64.5 10.8 1.2e-17 64.5 10.8 13.0 3 3 9 12 12 12 1 Ciliary rootlet component, centrosome cohesion DUF3450 PF11932.6 001351305.1_26229001_1 - 0.00079 18.7 3.0 0.00079 18.7 3.0 17.2 4 3 14 19 19 19 3 Protein of unknown function (DUF3450) CheY-binding PF09078.9 001351305.1_26229001_1 - 2.4 8.2 10.5 4.4 7.4 0.5 4.7 3 0 0 3 3 3 0 CheY binding RRM_5 PF13893.4 214231.3_49827001_2 - 1.2e-62 208.9 0.5 1.8e-43 147.0 0.0 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.20 214231.3_49827001_2 - 5.3e-37 125.4 0.8 2.3e-10 40.0 0.0 4.8 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 214231.3_49827001_2 - 7.5e-10 38.4 0.3 0.083 12.6 0.0 4.4 4 0 0 4 4 4 4 Occluded RNA-recognition motif Globin PF00042.20 001032986.2_32322001_1 - 3.9e-23 82.0 0.1 6.2e-23 81.3 0.1 1.3 1 0 0 1 1 1 1 Globin GST_N PF02798.18 214389.2_49823001_2 - 1.9e-20 72.8 0.0 4.3e-20 71.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.4 214389.2_49823001_2 - 1.3e-19 70.1 0.0 2e-19 69.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 214389.2_49823001_2 - 1.6e-19 69.7 0.0 3.2e-19 68.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 214389.2_49823001_2 - 0.052 13.8 0.0 0.2 12.0 0.0 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain UPF0020 PF01170.16 001350597.1_26226001_3 - 1.1e-05 25.1 0.0 0.018 14.6 0.0 2.2 2 0 0 2 2 2 2 Putative RNA methylase family UPF0020 Peptidase_C2 PF00648.19 001348784.2_49827001_1 - 8.3e-129 428.7 0.0 1.5e-128 427.9 0.0 1.4 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 001348784.2_49827001_1 - 2.2e-53 180.2 0.0 6.2e-53 178.7 0.0 1.7 2 0 0 2 2 2 1 Calpain large subunit, domain III EF-hand_8 PF13833.4 001348784.2_49827001_1 - 1.1e-12 47.4 7.1 1.5e-09 37.4 0.1 4.2 4 1 0 4 4 4 2 EF-hand domain pair EF-hand_1 PF00036.30 001348784.2_49827001_1 - 9.3e-10 37.2 4.4 0.0082 15.5 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 001348784.2_49827001_1 - 1.5e-09 36.9 5.4 0.0058 16.3 0.0 4.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.4 001348784.2_49827001_1 - 1.2e-07 31.9 5.5 0.031 14.6 0.0 3.8 3 2 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 001348784.2_49827001_1 - 0.67 9.5 7.7 3 7.4 0.0 3.9 4 0 0 4 4 4 0 EF hand RabGAP-TBC PF00566.16 001350045.1_26226001_3 - 1.2e-51 175.3 0.3 1.6e-51 174.9 0.3 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain RUN PF02759.17 001350045.1_26226001_3 - 7.8e-33 113.2 0.3 1.6e-32 112.1 0.1 1.7 2 0 0 2 2 2 1 RUN domain SH3_1 PF00018.26 001350045.1_26226001_3 - 1.8e-11 43.3 0.1 3.2e-11 42.5 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 001350045.1_26226001_3 - 3.4e-09 36.1 0.0 7.4e-09 35.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 001350045.1_26226001_3 - 4.6e-09 35.9 0.0 9.1e-09 34.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DnaJ PF00226.29 001206401.1_49823001_1 - 5.7e-27 93.5 0.5 9.2e-27 92.8 0.5 1.3 1 0 0 1 1 1 1 DnaJ domain PMG PF05287.10 181622.2_26222001_3 - 1.6e-48 165.0 55.5 1.7e-48 164.9 55.5 1.0 1 0 0 1 1 1 1 PMG protein Keratin_B2 PF01500.15 181622.2_26222001_3 - 0.44 10.4 43.7 1.7 8.4 10.2 2.2 1 1 1 2 2 2 0 Keratin, high sulfur B2 protein SRCR PF00530.16 001281681.1_31324001_3 - 1.3e-29 102.5 0.9 3.1e-29 101.3 0.9 1.7 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain BACK PF07707.13 001281681.1_31324001_3 - 7.5e-15 54.8 1.5 7.5e-15 54.8 1.5 1.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch SRCR_2 PF15494.4 001281681.1_31324001_3 - 0.00045 20.5 0.5 0.0016 18.8 0.1 2.1 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain BTB PF00651.29 001281681.1_31324001_3 - 0.0025 17.9 0.0 0.018 15.1 0.0 2.1 1 1 0 1 1 1 1 BTB/POZ domain VRP1 PF03538.12 001281681.1_31324001_3 - 0.099 11.9 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Salmonella virulence plasmid 28.1kDa A protein Hemopexin PF00045.17 001082760.1_37923001_3 - 8e-44 147.2 9.8 9.6e-11 41.3 0.0 7.0 7 0 0 7 7 7 5 Hemopexin Esterase PF00756.18 214060.1_49823001_3 - 2.8e-72 243.3 0.0 3.2e-72 243.0 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.19 214060.1_49823001_3 - 8.6e-05 22.0 0.0 0.00012 21.5 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Chlorophyllase2 PF12740.5 214060.1_49823001_3 - 9.1e-05 21.4 0.0 0.00013 20.8 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Esterase_phd PF10503.7 214060.1_49823001_3 - 0.00016 21.1 0.0 0.00088 18.7 0.0 1.9 1 1 0 1 1 1 1 Esterase PHB depolymerase Hydrolase_4 PF12146.6 214060.1_49823001_3 - 0.00068 18.8 0.0 0.001 18.3 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 AXE1 PF05448.10 214060.1_49823001_3 - 0.0014 17.3 0.0 0.002 16.7 0.0 1.1 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) Abhydrolase_2 PF02230.14 214060.1_49823001_3 - 0.099 12.3 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Chlorophyllase PF07224.9 214060.1_49823001_3 - 0.1 11.4 0.0 0.58 9.0 0.0 1.9 1 1 0 1 1 1 0 Chlorophyllase Abhydrolase_3 PF07859.11 214060.1_49823001_3 - 0.13 12.0 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.23 214060.1_49823001_3 - 0.17 11.6 0.0 0.26 11.0 0.0 1.2 1 0 0 1 1 1 0 Lipase (class 3) LIM PF00412.20 017556.3_26227001_3 - 1.5e-28 98.6 46.1 2.2e-15 56.5 7.0 3.8 4 0 0 4 4 4 3 LIM domain Pkinase PF00069.23 001161857.1_39523001_1 - 3.1e-78 262.6 0.0 4e-78 262.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001161857.1_39523001_1 - 1.6e-35 122.5 0.0 2.4e-35 121.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.27 001161857.1_39523001_1 - 4.5e-17 62.3 0.2 1e-16 61.2 0.2 1.7 1 0 0 1 1 1 1 PH domain Pkinase_C PF00433.22 001161857.1_39523001_1 - 8.4e-10 39.1 3.4 1.7e-09 38.1 3.4 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 001161857.1_39523001_1 - 1.1e-08 34.6 0.0 9.4e-08 31.6 0.0 2.0 2 0 0 2 2 2 1 Kinase-like PH_11 PF15413.4 001161857.1_39523001_1 - 0.012 15.9 0.4 0.055 13.8 0.0 2.3 3 0 0 3 3 3 0 Pleckstrin homology domain Seadorna_VP7 PF07387.9 001161857.1_39523001_1 - 0.044 12.7 0.0 0.069 12.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.21 001161857.1_39523001_1 - 0.083 12.7 0.0 0.23 11.2 0.0 1.9 1 1 0 1 1 1 0 Phosphotransferase enzyme family An_peroxidase PF03098.13 001285617.1_09025001_1 - 1.6e-175 584.6 0.0 2e-175 584.3 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase Sema PF01403.17 004186.4_26228001_2 - 3.6e-145 483.8 0.0 5.6e-145 483.2 0.0 1.3 1 0 0 1 1 1 1 Sema domain Ig_3 PF13927.4 004186.4_26228001_2 - 4.1e-05 24.0 0.0 0.0001 22.7 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 004186.4_26228001_2 - 0.00016 21.5 0.0 0.00033 20.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 004186.4_26228001_2 - 0.0013 18.7 0.0 0.003 17.6 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain PSI PF01437.23 004186.4_26228001_2 - 0.0048 17.3 9.0 0.011 16.1 9.0 1.6 1 0 0 1 1 1 1 Plexin repeat V-set PF07686.15 004186.4_26228001_2 - 0.014 15.4 0.1 0.17 11.9 0.1 2.3 1 1 0 1 1 1 0 Immunoglobulin V-set domain Ig_2 PF13895.4 004186.4_26228001_2 - 0.041 14.1 0.1 0.16 12.2 0.0 2.1 2 0 0 2 2 2 0 Immunoglobulin domain ATAD4 PF15321.4 001329996.1_26224001_3 - 9.4e-23 81.3 0.0 1.4e-22 80.7 0.0 1.3 1 0 0 1 1 1 1 ATPase family AAA domain containing 4 WD40 PF00400.30 001243898.1_49825001_2 - 1.3e-40 136.5 7.0 5.3e-08 33.3 0.1 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001243898.1_49825001_2 - 2.1e-17 63.0 0.1 1.5e-05 25.0 0.0 5.3 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 001243898.1_49825001_2 - 8.6e-13 47.8 0.5 0.0082 15.0 0.1 3.7 2 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.6 001243898.1_49825001_2 - 5.8e-08 31.7 0.2 0.0066 15.0 0.1 3.8 2 1 2 4 4 4 2 Nucleoporin Nup120/160 LisH PF08513.9 001243898.1_49825001_2 - 0.025 14.4 0.0 0.055 13.3 0.0 1.6 1 0 0 1 1 1 0 LisH PD40 PF07676.10 001243898.1_49825001_2 - 0.038 13.8 0.0 0.88 9.5 0.0 3.0 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Hira PF07569.9 001243898.1_49825001_2 - 0.14 11.8 3.4 18 4.8 0.0 4.3 5 0 0 5 5 5 0 TUP1-like enhancer of split zf-rbx1 PF12678.5 037702.1_26225120_2 - 1.9e-15 56.8 21.0 2.5e-14 53.2 14.2 3.1 3 0 0 3 3 3 2 RING-H2 zinc finger domain zf-ANAPC11 PF12861.5 037702.1_26225120_2 - 1.2e-09 38.0 22.2 6.9e-07 29.1 9.1 2.8 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.4 037702.1_26225120_2 - 4e-06 26.9 13.0 4e-06 26.9 13.0 2.9 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.4 037702.1_26225120_2 - 0.14 11.9 18.6 0.02 14.6 13.5 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 037702.1_26225120_2 - 0.99 9.2 17.8 0.11 12.3 12.4 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 037702.1_26225120_2 - 2.8 7.7 19.7 0.44 10.3 11.3 3.0 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Glyco_hydro_47 PF01532.18 001355008.1_26225001_2 - 2e-113 379.6 0.0 2.5e-113 379.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Sec7 PF01369.18 001355231.1_32929001_1 - 2.5e-33 115.2 0.0 3.6e-33 114.7 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.4 001355231.1_32929001_1 - 4.3e-32 110.8 0.0 7.4e-32 110.1 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.27 001355231.1_32929001_1 - 9.1e-08 32.4 0.0 1.9e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 PH domain SelK_SelG PF10961.6 037671.1_45724120_1 - 1.6e-13 50.9 0.8 1.4e-08 35.1 0.1 2.5 2 0 0 2 2 2 2 Selenoprotein SelK_SelG THAP PF05485.10 001130475.2_26227001_2 - 4.1e-15 56.4 3.2 5e-15 56.1 1.0 2.2 2 0 0 2 2 2 1 THAP domain ADIP PF11559.6 001130475.2_26227001_2 - 0.0024 17.8 1.5 0.0073 16.3 1.5 1.8 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding GHMP_kinases_N PF00288.24 138656.2_32924001_3 - 7.6e-06 25.9 3.7 1.5e-05 25.0 3.7 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain Casc1_N PF15927.3 001352061.1_26226001_3 - 9.9e-63 211.3 12.1 9.9e-63 211.3 12.1 2.6 3 0 0 3 3 3 1 Cancer susceptibility candidate 1 N-terminus Ras PF00071.20 021033.6_26229001_2 - 2.9e-55 186.1 0.0 4.1e-55 185.7 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 021033.6_26229001_2 - 4.6e-19 68.7 0.1 1e-18 67.6 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 021033.6_26229001_2 - 1.2e-08 34.5 0.0 1.9e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 021033.6_26229001_2 - 7.2e-05 22.6 0.5 0.014 15.1 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 021033.6_26229001_2 - 0.0016 17.9 0.0 0.0033 16.8 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 021033.6_26229001_2 - 0.0058 16.6 0.0 0.01 15.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase TPP_enzyme_M PF00205.20 021033.6_26229001_2 - 0.095 12.3 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain MMR_HSR1_Xtn PF16897.3 021033.6_26229001_2 - 0.1 12.5 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain zf-C2H2_11 PF16622.3 001353530.1_26229001_3 - 4.3e-18 64.6 59.6 3.4e-16 58.6 3.8 9.4 10 0 0 10 10 10 5 zinc-finger C2H2-type zf-C2H2 PF00096.24 001353530.1_26229001_3 - 2e-13 49.8 119.8 0.0034 17.6 0.5 16.1 15 0 0 15 15 15 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001353530.1_26229001_3 - 1.5e-07 31.5 121.0 0.003 18.1 0.3 16.1 17 0 0 17 17 17 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001353530.1_26229001_3 - 5.7e-06 26.0 0.2 5.7e-06 26.0 0.2 10.8 12 0 0 12 12 12 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001353530.1_26229001_3 - 8.7e-06 25.8 1.8 0.0006 19.9 0.2 9.8 12 0 0 12 12 12 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 001353530.1_26229001_3 - 0.014 15.6 0.2 0.014 15.6 0.2 10.6 10 0 0 10 10 10 0 Zinc-finger of C2H2 type CG-1 PF03859.14 001349609.1_26229001_1 - 3.4e-42 142.8 2.8 6.7e-42 141.8 2.8 1.5 1 0 0 1 1 1 1 CG-1 domain TIG PF01833.22 001349609.1_26229001_1 - 1.7e-10 40.7 0.1 5e-10 39.2 0.1 1.9 1 0 0 1 1 1 1 IPT/TIG domain Ank_2 PF12796.5 001349609.1_26229001_1 - 1.9e-09 37.9 0.2 4.6e-05 23.8 0.0 1.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001349609.1_26229001_1 - 4.1e-05 23.7 0.1 0.52 10.6 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) IQ PF00612.25 001349609.1_26229001_1 - 0.00011 21.6 13.5 0.22 11.3 0.5 4.8 4 0 0 4 4 4 3 IQ calmodulin-binding motif Ank_3 PF13606.4 001349609.1_26229001_1 - 0.0008 19.6 0.6 1.8 9.2 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.4 001349609.1_26229001_1 - 0.0012 19.3 0.5 0.075 13.5 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.28 001349609.1_26229001_1 - 0.032 14.6 0.3 6.1 7.3 0.1 2.7 2 0 0 2 2 2 0 Ankyrin repeat Claudin_2 PF13903.4 001040199.1_26225001_1 - 1.2e-21 77.2 1.5 1.8e-21 76.7 1.5 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.18 001040199.1_26225001_1 - 1.4e-10 41.1 4.2 2.6e-08 33.8 4.2 2.6 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family zf-C2H2 PF00096.24 001355445.1_26225001_1 - 7.5e-08 32.3 17.1 8.5e-05 22.7 1.9 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001355445.1_26225001_1 - 9.9e-08 32.0 23.0 1.3e-05 25.2 0.7 5.0 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_6 PF13912.4 001355445.1_26225001_1 - 6e-05 22.8 6.6 0.088 12.7 1.0 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_4 PF13894.4 001355445.1_26225001_1 - 0.0073 16.9 15.4 0.039 14.7 1.6 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001355445.1_26225001_1 - 0.0085 16.1 4.5 0.027 14.4 4.5 1.9 1 1 0 1 1 1 1 Zinc ribbon domain XPA_N PF01286.16 001355445.1_26225001_1 - 0.16 11.9 2.5 15 5.6 0.3 2.7 2 0 0 2 2 2 0 XPA protein N-terminal zf-H2C2_2 PF13465.4 001355445.1_26225001_2 - 1.2e-40 136.1 51.7 3.3e-09 36.7 0.5 8.5 8 0 0 8 8 8 7 Zinc-finger double domain zf-C2H2 PF00096.24 001355445.1_26225001_2 - 1.2e-31 107.2 51.5 5.7e-06 26.4 1.8 8.3 8 0 0 8 8 8 6 Zinc finger, C2H2 type KRAB PF01352.25 001355445.1_26225001_2 - 1.7e-21 75.5 0.1 3.3e-21 74.5 0.1 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 001355445.1_26225001_2 - 2.4e-15 55.8 49.1 0.0084 16.7 1.3 7.8 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001355445.1_26225001_2 - 1.5e-05 24.7 42.8 0.054 13.3 1.5 7.3 7 0 0 7 7 7 4 C2H2-type zinc finger C1_4 PF07975.10 001355445.1_26225001_2 - 0.00061 19.9 28.1 0.093 12.9 3.8 4.9 2 2 2 4 4 4 3 TFIIH C1-like domain DUF4934 PF16288.3 001355445.1_26225001_2 - 0.87 9.4 3.4 6.6 6.6 0.5 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4934) zf-AN1 PF01428.14 001355445.1_26225001_2 - 1.6 8.8 36.5 0.84 9.7 5.7 6.6 4 2 2 6 6 6 0 AN1-like Zinc finger Zn_Tnp_IS1595 PF12760.5 001355445.1_26225001_2 - 3.3 7.6 30.5 2.4 8.1 4.5 5.9 5 1 1 6 6 6 0 Transposase zinc-ribbon domain XPA_N PF01286.16 001355445.1_26225001_2 - 3.5 7.6 37.0 8.4 6.4 0.4 7.0 7 0 0 7 7 7 0 XPA protein N-terminal zf-C2H2_jaz PF12171.6 001355445.1_26225001_2 - 4.4 7.6 49.8 0.99 9.7 1.9 7.5 8 0 0 8 8 8 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 001355445.1_26225001_2 - 7.8 6.6 44.5 0.79 9.8 5.1 5.3 3 2 3 6 6 6 0 Zinc ribbon domain BIR PF00653.19 001199717.1_09921001_1 - 5.6e-24 84.5 2.7 9.1e-24 83.8 2.7 1.3 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain Transketolase_N PF00456.19 001064.3_26225001_2 - 1e-43 149.5 0.0 1.9e-43 148.6 0.0 1.4 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.22 001064.3_26225001_2 - 1.1e-41 142.3 0.0 2.3e-41 141.3 0.0 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.18 001064.3_26225001_2 - 3.1e-31 107.7 0.2 5.7e-31 106.8 0.2 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain E1_dh PF00676.18 001064.3_26225001_2 - 1.4e-08 33.9 0.0 2.4e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.4 001064.3_26225001_2 - 5.8e-06 25.6 0.0 0.0002 20.5 0.0 2.6 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.19 001064.3_26225001_2 - 8.2e-05 22.3 0.1 0.0011 18.6 0.1 2.6 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain XFP_N PF09364.8 001064.3_26225001_2 - 0.0015 17.2 0.0 0.0025 16.5 0.0 1.3 1 0 0 1 1 1 1 XFP N-terminal domain Alba PF01918.19 001064.3_26225001_2 - 0.092 12.5 0.6 0.22 11.2 0.1 2.0 2 0 0 2 2 2 0 Alba stn_TNFRSF12A PF12191.6 009259.5_32928001_1 - 0.048 13.8 0.2 0.13 12.4 0.2 1.7 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain Gpi16 PF04113.12 047692.1_26225120_1 - 4.2e-23 81.5 0.0 5.5e-23 81.1 0.0 1.1 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component Gpi16 PF04113.12 047692.1_26225120_2 - 7.9e-14 50.9 0.3 1.1e-13 50.4 0.3 1.1 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component Gpi16 PF04113.12 047692.1_26225120_3 - 8.9e-82 275.2 0.2 2.7e-80 270.3 0.2 2.0 1 1 0 1 1 1 1 Gpi16 subunit, GPI transamidase component TMEM154 PF15102.4 110337.1_32925120_1 - 0.027 14.3 0.6 0.027 14.3 0.6 3.0 2 2 1 3 3 3 0 TMEM154 protein family stn_TNFRSF12A PF12191.6 110337.1_32925120_1 - 0.062 13.4 0.2 0.062 13.4 0.2 1.7 2 0 0 2 2 2 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain SKG6 PF08693.8 110337.1_32925120_1 - 0.27 10.5 1.8 0.65 9.3 1.8 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Ric8 PF10165.7 147139.1_26229120_1 - 3.5e-11 42.7 0.1 4.8e-11 42.2 0.1 1.1 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn Ric8 PF10165.7 147139.1_26229120_2 - 9.4e-57 192.9 9.4 1.2e-56 192.5 9.4 1.1 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn Zip PF02535.20 110981.1_32924120_1 - 6e-38 130.8 1.9 6e-38 130.8 1.9 1.9 1 1 1 2 2 2 1 ZIP Zinc transporter Zip PF02535.20 110981.1_32924120_2 - 0.0004 19.6 0.2 0.00059 19.0 0.2 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter WD40 PF00400.30 001355523.1_32925001_1 - 8.1e-18 64.3 5.8 6.2e-06 26.7 0.1 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001355523.1_32925001_1 - 6.2e-06 26.3 0.0 0.094 12.9 0.0 3.0 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 001355523.1_32925001_1 - 0.0024 16.4 0.5 0.1 11.1 0.1 2.7 1 1 2 3 3 3 1 Nucleoporin Nup120/160 Thiolase_N PF00108.21 001034119.1_39725001_2 - 9.8e-86 287.2 0.2 1.4e-85 286.7 0.2 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.16 001034119.1_39725001_2 - 3.5e-49 165.4 0.0 6.2e-49 164.6 0.0 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.24 001034119.1_39725001_2 - 3.1e-07 30.1 0.8 1e-06 28.4 0.2 2.2 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.8 001034119.1_39725001_2 - 0.17 11.6 1.0 3.8 7.3 0.2 2.5 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Peptidase_M16 PF00675.18 001280125.1_39724001_1 - 4.5e-50 169.4 0.0 6.4e-50 168.9 0.0 1.2 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.19 001280125.1_39724001_1 - 6.2e-32 110.9 0.0 1.3e-31 110.0 0.0 1.5 2 0 0 2 2 2 1 Peptidase M16 inactive domain TMCO5 PF14992.4 001355572.1_32923001_3 - 7.8e-88 294.5 32.3 6.3e-45 153.8 1.2 2.1 1 1 1 2 2 2 2 TMCO5 family VGPC1_C PF16799.3 001355572.1_32923001_3 - 0.064 13.1 8.6 0.28 11.1 0.7 3.3 3 0 0 3 3 3 0 C-terminal membrane-localisation domain of ion-channel, VCN1 TMEM191C PF15194.4 001355572.1_32923001_3 - 0.081 12.9 0.3 0.17 11.9 0.3 1.5 1 0 0 1 1 1 0 TMEM191C family V_ATPase_I PF01496.17 001355572.1_32923001_3 - 0.089 10.5 13.3 0.11 10.2 13.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Synaptobrevin PF00957.19 001355572.1_32923001_3 - 0.11 12.2 1.9 0.23 11.1 1.9 1.6 1 0 0 1 1 1 0 Synaptobrevin Vac_Fusion PF02346.14 001355572.1_32923001_3 - 0.13 11.7 11.6 1.4 8.5 1.1 3.4 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 CENP-F_leu_zip PF10473.7 001355572.1_32923001_3 - 0.14 12.1 43.3 4 7.3 24.2 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Syntaxin_2 PF14523.4 001355572.1_32923001_3 - 0.85 9.9 12.0 0.78 10.0 9.9 2.0 1 1 1 2 2 2 0 Syntaxin-like protein MMR_HSR1_C PF08438.8 001355572.1_32923001_3 - 1.1 9.8 7.4 0.2 12.1 2.5 2.1 1 1 1 2 2 2 0 GTPase of unknown function C-terminal DUF3037 PF11236.6 001355572.1_32923001_3 - 1.8 8.9 6.9 20 5.5 3.7 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3037) DUF4407 PF14362.4 001355572.1_32923001_3 - 3 7.0 16.7 84 2.2 16.7 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2852 PF11014.6 001355572.1_32923001_3 - 3.4 7.7 6.8 0.44 10.6 2.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2852) CENP-H PF05837.10 001355572.1_32923001_3 - 7.5 6.9 29.7 7.3 6.9 6.1 3.1 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Ammonium_transp PF00909.19 001009033.1_39723001_1 - 9.1e-91 304.4 25.9 1.2e-90 304.0 25.9 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family AzlD PF05437.10 001009033.1_39723001_1 - 0.17 11.9 12.0 0.047 13.7 3.1 3.9 2 1 3 5 5 5 0 Branched-chain amino acid transport protein (AzlD) PK PF00224.19 001195644.1_37924001_1 - 2.3e-171 569.2 1.6 2.8e-171 569.0 1.6 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.14 001195644.1_37924001_1 - 4.7e-34 117.0 0.1 1.7e-33 115.2 0.0 2.0 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.12 001195644.1_37924001_1 - 0.00032 19.8 0.3 0.00074 18.6 0.2 1.6 1 1 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family IMPDH PF00478.23 001195644.1_37924001_1 - 0.054 12.4 0.1 0.28 10.0 0.0 2.0 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain PNMA PF14893.4 001348450.1_29524001_2 - 1e-126 422.7 2.7 1.2e-126 422.4 2.7 1.1 1 0 0 1 1 1 1 PNMA Retrotrans_gag PF03732.15 001348450.1_29524001_2 - 7.7e-05 22.8 0.0 0.00014 21.9 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon gag protein PK PF00224.19 001159690.2_21025001_3 - 4.4e-171 568.3 1.5 5.4e-171 568.0 1.5 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.14 001159690.2_21025001_3 - 1.2e-33 115.7 0.0 2.9e-33 114.4 0.0 1.7 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.12 001159690.2_21025001_3 - 0.0048 15.9 0.5 0.019 13.9 0.1 2.0 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family Fox-1_C PF12414.6 001284993.1_29524001_2 - 5.8e-36 122.6 22.8 5.6e-20 71.3 4.6 2.8 2 0 0 2 2 2 2 Calcitonin gene-related peptide regulator C terminal RRM_1 PF00076.20 001284993.1_29524001_2 - 1.2e-18 66.5 1.2 1.4e-18 66.3 0.1 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1777 PF08648.10 001284993.1_29524001_2 - 0.0008 19.6 17.3 0.0017 18.5 17.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) RRM_5 PF13893.4 001284993.1_29524001_2 - 0.036 13.5 0.0 0.061 12.8 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 PF10243.7 001284993.1_29524001_2 - 3.1 6.3 16.7 4.9 5.6 16.7 1.3 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 RED_N PF07808.11 001280036.1_39724001_3 - 9.3e-102 339.5 16.1 9.3e-102 339.5 16.1 2.8 2 0 0 2 2 2 1 RED-like protein N-terminal region RED_C PF07807.9 001280036.1_39724001_3 - 4.6e-49 165.4 8.0 4.6e-49 165.4 8.0 3.6 4 1 0 4 4 4 1 RED-like protein C-terminal region PRP38_assoc PF12871.5 001280036.1_39724001_3 - 0.00035 20.9 30.2 0.00035 20.9 30.2 3.5 3 0 0 3 3 3 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Lsm_interact PF05391.9 001280036.1_39724001_3 - 0.0075 15.6 0.1 0.048 13.0 0.1 2.5 1 0 0 1 1 1 1 Lsm interaction motif MCR_C PF04609.10 001280036.1_39724001_3 - 0.048 12.6 0.2 0.12 11.3 0.2 1.6 1 0 0 1 1 1 0 Methyl-coenzyme M reductase operon protein C Mab-21 PF03281.12 001193712.2_29625001_1 - 2.7e-14 53.1 0.0 1.8e-12 47.1 0.0 2.2 1 1 0 1 1 1 1 Mab-21 protein CbtA PF09490.8 001193712.2_29625001_1 - 0.67 9.5 5.8 0.079 12.6 1.1 1.7 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) PNMA PF14893.4 001256914.1_21023001_1 - 2.8e-135 450.9 0.0 3.3e-135 450.6 0.0 1.1 1 0 0 1 1 1 1 PNMA HTH_23 PF13384.4 001256914.1_21023001_1 - 0.066 12.9 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain AmpE PF17113.3 001256914.1_21023001_1 - 0.13 11.4 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Regulatory signalling modulator protein AmpE DUF766 PF05571.10 001260993.1_29625001_3 - 8e-114 380.1 18.6 1.2e-113 379.5 18.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF766) RED_N PF07808.11 001319450.1_29524001_2 - 8.8e-102 339.5 16.1 8.8e-102 339.5 16.1 2.6 2 0 0 2 2 2 1 RED-like protein N-terminal region RED_C PF07807.9 001319450.1_29524001_2 - 4.5e-49 165.5 8.0 4.5e-49 165.5 8.0 3.3 3 1 0 3 3 3 1 RED-like protein C-terminal region PRP38_assoc PF12871.5 001319450.1_29524001_2 - 0.00034 21.0 30.2 0.00034 21.0 30.2 3.5 3 0 0 3 3 3 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Lsm_interact PF05391.9 001319450.1_29524001_2 - 0.0083 15.5 0.1 0.047 13.1 0.1 2.4 1 0 0 1 1 1 1 Lsm interaction motif MCR_C PF04609.10 001319450.1_29524001_2 - 0.046 12.6 0.2 0.12 11.3 0.2 1.6 1 0 0 1 1 1 0 Methyl-coenzyme M reductase operon protein C Phosphodiest PF01663.20 001266236.1_29628001_2 - 4e-84 283.1 1.9 4.7e-84 282.9 1.9 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.21 001266236.1_29628001_2 - 2.9e-07 30.1 0.0 2.5e-05 23.7 0.0 2.2 2 0 0 2 2 2 2 Sulfatase PglZ PF08665.10 001266236.1_29628001_2 - 0.15 12.0 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 PglZ domain PNMA PF14893.4 001261481.2_29628001_3 - 2.1e-132 441.4 0.8 3.4e-132 440.7 0.8 1.3 1 0 0 1 1 1 1 PNMA zf-CCHC PF00098.21 001261481.2_29628001_3 - 0.35 10.9 7.9 0.039 13.9 2.8 2.1 2 0 0 2 2 2 0 Zinc knuckle Fox-1_C PF12414.6 001244837.1_49824001_3 - 3.9e-44 148.8 22.7 3.9e-44 148.8 22.7 2.1 2 0 0 2 2 2 1 Calcitonin gene-related peptide regulator C terminal RRM_1 PF00076.20 001244837.1_49824001_3 - 4.7e-18 64.6 0.1 4.7e-18 64.6 0.1 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 001244837.1_49824001_3 - 0.038 13.5 0.0 0.074 12.5 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 001244837.1_49824001_3 - 0.051 13.4 0.1 0.77 9.6 0.0 2.5 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif PK PF00224.19 001143794.2_21025001_3 - 3.6e-171 568.6 1.3 4.3e-171 568.3 1.3 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.14 001143794.2_21025001_3 - 7.2e-34 116.4 0.1 1.8e-33 115.1 0.1 1.7 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.12 001143794.2_21025001_3 - 0.0097 14.9 0.1 0.019 14.0 0.1 1.5 1 1 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family Ammonium_transp PF00909.19 001279570.1_24223001_1 - 2.1e-91 306.5 25.3 2.7e-91 306.1 25.3 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family AzlD PF05437.10 001279570.1_24223001_1 - 0.02 14.9 1.1 0.02 14.9 1.1 3.8 3 2 2 5 5 5 0 Branched-chain amino acid transport protein (AzlD) 3HCDH_N PF02737.16 001265890.1_29626001_3 - 8.8e-54 182.0 0.4 1.6e-53 181.2 0.4 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.18 001265890.1_29626001_3 - 4.1e-39 134.3 0.0 6.4e-39 133.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase 3HCDH PF00725.20 001265890.1_29626001_3 - 5.5e-36 122.9 0.0 2.8e-27 95.0 0.0 2.7 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_2 PF16113.3 001265890.1_29626001_3 - 4.5e-25 88.7 0.0 1.3e-24 87.3 0.0 1.7 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase FeThRed_B PF02943.13 001265890.1_29626001_3 - 0.12 12.2 0.0 0.3 11.0 0.0 1.6 1 0 0 1 1 1 0 Ferredoxin thioredoxin reductase catalytic beta chain Peptidase_M16 PF00675.18 001246530.1_39724001_3 - 1.8e-32 112.2 0.0 2.9e-32 111.6 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.19 001246530.1_39724001_3 - 1.8e-20 73.6 0.1 2.8e-20 73.0 0.1 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain DUF1471 PF07338.11 001246530.1_39724001_3 - 0.041 13.7 0.2 0.2 11.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1471) PK PF00224.19 001195645.1_37924001_1 - 1.8e-171 569.6 1.4 2.2e-171 569.3 1.4 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.14 001195645.1_37924001_1 - 2.6e-34 117.8 0.1 9.2e-34 116.0 0.1 2.0 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.12 001195645.1_37924001_1 - 0.00034 19.7 0.2 0.00073 18.6 0.2 1.6 1 1 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family IMPDH PF00478.23 001195645.1_37924001_1 - 0.059 12.2 0.1 0.28 10.0 0.0 2.0 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain HLH PF00010.24 001281578.1_31322001_3 - 1.6e-12 47.0 0.4 2.8e-12 46.3 0.4 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Thiolase_N PF00108.21 001348972.1_49825001_3 - 4.9e-84 281.6 0.2 7e-84 281.1 0.2 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.16 001348972.1_49825001_3 - 2.1e-49 166.1 0.0 3.6e-49 165.4 0.0 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.24 001348972.1_49825001_3 - 4.3e-07 29.6 0.3 1.7e-06 27.7 0.1 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.8 001348972.1_49825001_3 - 0.22 11.3 1.8 3.3 7.5 0.1 2.6 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 3HCDH_N PF02737.16 001136490.1_39526001_1 - 4e-52 176.6 0.3 7.6e-52 175.7 0.3 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.18 001136490.1_39526001_1 - 1.7e-39 135.5 0.0 2.8e-39 134.8 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase 3HCDH PF00725.20 001136490.1_39526001_1 - 7.6e-33 112.9 0.0 1.3e-25 89.7 0.0 2.8 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_2 PF16113.3 001136490.1_39526001_1 - 4.8e-24 85.3 0.0 8.2e-24 84.6 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase RRM_1 PF00076.20 027515.1_32926120_3 - 0.0021 17.7 0.0 0.0036 16.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPR_2 PF07719.15 001355690.1_32929001_1 - 6.5e-23 78.8 2.0 0.00062 19.6 0.0 7.4 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_1 PF00515.26 001355690.1_32929001_1 - 1.1e-22 78.7 4.9 0.00033 20.2 0.0 7.5 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.4 001355690.1_32929001_1 - 3.1e-13 48.7 0.4 0.017 15.2 0.0 6.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.4 001355690.1_32929001_1 - 1e-12 47.4 0.7 0.055 13.0 0.0 6.6 5 2 2 7 7 7 5 TPR repeat TPR_12 PF13424.4 001355690.1_32929001_1 - 1.9e-11 44.0 13.8 0.12 12.5 0.9 7.2 4 2 2 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.4 001355690.1_32929001_1 - 1.4e-10 40.3 4.9 0.08 12.9 0.0 6.6 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_14 PF13428.4 001355690.1_32929001_1 - 6.5e-06 26.4 5.8 0.68 10.8 0.0 6.6 7 2 2 9 9 8 1 Tetratricopeptide repeat TPR_9 PF13371.4 001355690.1_32929001_1 - 6e-05 23.0 0.5 0.3 11.1 0.0 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.4 001355690.1_32929001_1 - 0.00049 19.8 13.1 0.94 9.3 0.0 6.4 8 0 0 8 8 8 3 Tetratricopeptide repeat ChAPs PF09295.8 001355690.1_32929001_1 - 0.00053 19.0 2.5 0.0037 16.2 0.3 2.9 3 0 0 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_19 PF14559.4 001355690.1_32929001_1 - 0.0015 18.9 2.8 1.7 9.1 0.1 4.7 3 2 1 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.4 001355690.1_32929001_1 - 0.0029 18.1 2.7 0.23 12.0 0.5 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.4 001355690.1_32929001_1 - 0.13 12.9 0.3 14 6.4 0.1 3.5 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.5 001355690.1_32929001_1 - 0.15 12.1 2.8 1.8 8.7 0.0 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.4 001355690.1_32929001_1 - 0.27 11.6 8.8 5.9 7.4 0.1 5.6 6 0 0 6 6 5 0 Tetratricopeptide repeat Glyco_transf_43 PF03360.14 001242626.1_39723001_1 - 6.1e-69 231.8 0.0 7.6e-69 231.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 43 JUPITER PF17054.3 001048048.1_39722001_3 - 7.2e-08 32.2 0.1 7.2e-08 32.2 0.1 1.5 2 0 0 2 2 2 1 Microtubule-Associated protein Jupiter Transket_pyr PF02779.22 001246418.1_39724001_1 - 7.4e-47 159.2 0.0 1.4e-46 158.3 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.18 001246418.1_39724001_1 - 5.3e-38 129.5 0.1 1.2e-37 128.5 0.1 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain zf-HC5HC2H PF13771.4 001280228.1_39725001_2 - 3.3e-18 65.6 4.8 3.3e-18 65.6 4.8 4.6 4 1 1 5 5 5 1 PHD-like zinc-binding domain HECT PF00632.23 001280228.1_39725001_2 - 1.6e-10 40.9 0.1 4.2e-10 39.5 0.1 1.6 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) zf-HC5HC2H_2 PF13832.4 001280228.1_39725001_2 - 2.8e-07 30.5 9.5 2.8e-07 30.5 9.5 3.6 2 1 2 4 4 4 1 PHD-zinc-finger like domain Glyco_transf_43 PF03360.14 001031619.1_39722001_1 - 1.8e-69 233.5 0.0 2.3e-69 233.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 43 NnrU PF07298.9 001040116.1_39722001_1 - 4.7e-05 22.8 7.6 9.3e-05 21.9 7.2 1.8 1 1 0 1 1 1 1 NnrU protein 7tm_1 PF00001.19 001048014.1_22425001_2 - 3.8e-31 108.2 26.8 6.2e-31 107.5 26.8 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GnHR_trans PF12369.6 001048014.1_22425001_2 - 2.4e-28 98.6 0.6 4.4e-28 97.8 0.6 1.5 1 0 0 1 1 1 1 Gonadotropin hormone receptor transmembrane region LRR_8 PF13855.4 001048014.1_22425001_2 - 1.3e-18 66.4 13.4 5.8e-06 25.9 0.1 5.2 1 1 4 5 5 5 5 Leucine rich repeat LRR_5 PF13306.4 001048014.1_22425001_2 - 7.3e-14 51.7 1.0 2.1e-07 30.8 0.1 2.4 1 1 0 2 2 2 2 Leucine rich repeats (6 copies) LRRNT PF01462.16 001048014.1_22425001_2 - 9.7e-09 34.6 2.7 9.7e-09 34.6 2.7 2.1 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_4 PF12799.5 001048014.1_22425001_2 - 0.0023 18.1 20.3 1.3 9.4 3.8 4.7 3 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001048014.1_22425001_2 - 0.41 10.0 5.1 0.33 10.3 1.5 2.4 1 1 0 2 2 2 0 Leucine-rich repeat LRR_1 PF00560.31 001048014.1_22425001_2 - 3.5 8.3 7.4 47 4.9 0.2 5.3 4 1 0 4 4 4 0 Leucine Rich Repeat Alpha-amylase_C PF02806.16 214195.1_49824001_1 - 4.2e-15 55.8 0.1 9.9e-15 54.7 0.1 1.6 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.22 214195.1_49824001_1 - 7.5e-12 45.3 0.0 1.2e-11 44.6 0.0 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain 7tm_1 PF00001.19 017255.1_45725001_1 - 1.2e-36 126.3 24.3 2e-36 125.5 24.3 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) tRNA_bind PF01588.18 007926.2_32923001_2 - 2.1e-31 107.8 0.8 4e-31 106.9 0.2 1.8 2 0 0 2 2 2 1 Putative tRNA binding domain APCDDC PF14921.4 007926.2_32923001_2 - 0.0019 17.6 0.4 0.0028 17.0 0.4 1.3 1 0 0 1 1 1 1 Adenomatosis polyposis coli down-regulated 1 NUDE_C PF04880.11 007926.2_32923001_2 - 0.0022 18.4 10.1 0.011 16.1 10.5 1.7 1 1 1 2 2 2 1 NUDE protein, C-terminal conserved region ALMT PF11744.6 007926.2_32923001_2 - 0.2 10.3 5.1 0.26 9.9 5.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Ribosomal_60s PF00428.17 007926.2_32923001_2 - 0.68 10.4 8.4 1.7 9.1 8.4 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein V_ATPase_I PF01496.17 007926.2_32923001_2 - 0.73 7.5 6.2 0.9 7.2 6.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PRP1_N PF06424.10 007926.2_32923001_2 - 5.1 7.4 10.6 3.2 8.0 3.5 2.4 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal PEPCK PF00821.16 001123158.1_49826001_3 - 1.8e-274 911.4 0.0 2e-274 911.2 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase Filament PF00038.19 001280716.1_39525001_1 - 7.9e-101 337.6 38.5 9.4e-101 337.3 38.5 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001280716.1_39525001_1 - 6.2e-20 71.8 42.6 3.7e-19 69.3 28.2 3.2 2 1 0 2 2 2 1 Keratin type II head CENP-F_leu_zip PF10473.7 001280716.1_39525001_1 - 4.6e-05 23.3 31.2 0.0036 17.2 8.6 3.5 1 1 3 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Alanine_zipper PF11839.6 001280716.1_39525001_1 - 0.0029 17.7 4.2 0.0029 17.7 4.2 2.2 2 0 0 2 2 2 1 Alanine-zipper, major outer membrane lipoprotein TPR_MLP1_2 PF07926.10 001280716.1_39525001_1 - 0.0085 16.0 2.6 0.0085 16.0 2.6 3.9 2 2 2 4 4 4 2 TPR/MLP1/MLP2-like protein Spc7 PF08317.9 001280716.1_39525001_1 - 0.033 12.9 36.0 0.025 13.3 11.7 3.2 1 1 3 4 4 4 0 Spc7 kinetochore protein Reo_sigmaC PF04582.10 001280716.1_39525001_1 - 0.044 13.1 8.9 0.056 12.7 1.4 2.6 1 1 2 3 3 3 0 Reovirus sigma C capsid protein DUF1664 PF07889.10 001280716.1_39525001_1 - 0.21 11.4 20.2 0.2 11.5 1.9 4.4 1 1 5 6 6 6 0 Protein of unknown function (DUF1664) DUF1732 PF08340.9 001280716.1_39525001_1 - 0.32 10.9 7.6 2.7 7.9 0.1 3.3 3 0 0 3 3 2 0 Domain of unknown function (DUF1732) Baculo_PEP_C PF04513.10 001280716.1_39525001_1 - 0.37 10.7 15.4 0.062 13.2 2.5 3.2 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus IncA PF04156.12 001280716.1_39525001_1 - 0.51 10.0 33.5 0.6 9.7 13.8 3.2 1 1 0 2 2 2 0 IncA protein JIP_LZII PF16471.3 001280716.1_39525001_1 - 0.53 10.4 19.0 11 6.1 0.5 5.1 3 1 2 5 5 5 0 JNK-interacting protein leucine zipper II NPV_P10 PF05531.10 001280716.1_39525001_1 - 0.91 9.9 14.6 0.27 11.6 0.9 4.2 3 2 1 4 4 4 0 Nucleopolyhedrovirus P10 protein Phage_GP20 PF06810.9 001280716.1_39525001_1 - 0.98 9.1 22.7 4.2 7.0 0.3 4.0 1 1 2 4 4 4 0 Phage minor structural protein GP20 Jnk-SapK_ap_N PF09744.7 001280716.1_39525001_1 - 1 9.4 29.1 0.063 13.4 2.0 3.3 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 DUF948 PF06103.9 001280716.1_39525001_1 - 1.2 9.3 2.9 13 6.0 2.4 2.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF5082 PF16888.3 001280716.1_39525001_1 - 1.3 9.3 25.9 0.28 11.4 4.6 4.1 1 1 1 4 4 4 0 Domain of unknown function (DUF5082) DUF4407 PF14362.4 001280716.1_39525001_1 - 1.6 7.9 20.7 0.77 8.9 1.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF883 PF05957.11 001280716.1_39525001_1 - 2.9 8.4 16.0 1 9.8 5.9 3.7 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF883) AAA_13 PF13166.4 001280716.1_39525001_1 - 3.8 5.9 27.6 0.38 9.2 5.9 2.1 1 1 1 2 2 2 0 AAA domain V_ATPase_I PF01496.17 001280716.1_39525001_1 - 4.1 5.0 20.0 0.18 9.5 5.7 2.2 1 1 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF4337 PF14235.4 001280716.1_39525001_1 - 8.7 6.3 14.6 0.1 12.6 4.0 2.7 2 2 0 2 2 2 0 Domain of unknown function (DUF4337) Casein_kappa PF00997.16 001009378.1_39522001_1 - 3.1e-76 254.8 13.8 4e-76 254.4 13.8 1.1 1 0 0 1 1 1 1 Kappa casein Neogenin_C PF06583.10 001009378.1_39522001_1 - 0.014 15.1 2.8 0.017 14.8 2.8 1.1 1 0 0 1 1 1 0 Neogenin C-terminus fn3 PF00041.19 178790.4_32929001_3 - 1.9e-16 60.0 4.3 4.7e-10 39.5 0.4 3.4 4 0 0 4 4 4 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 178790.4_32929001_3 - 5.5e-06 26.7 1.0 0.082 13.3 0.0 3.0 3 0 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 178790.4_32929001_3 - 0.00069 19.8 0.0 0.39 10.9 0.0 2.9 2 0 0 2 2 2 2 Interferon-alpha/beta receptor, fibronectin type III SAM_1 PF00536.28 026221.2_32929001_1 - 3.2e-39 133.0 7.2 3.8e-17 62.4 0.2 3.7 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 026221.2_32929001_1 - 7.7e-34 115.5 5.3 3.1e-14 52.7 0.0 3.7 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) DUF16 PF01519.14 026221.2_32929001_1 - 0.0014 18.9 1.6 0.0014 18.9 1.6 2.7 2 0 0 2 2 2 1 Protein of unknown function DUF16 SAM_PNT PF02198.14 026221.2_32929001_1 - 0.0019 18.0 3.7 0.37 10.7 0.2 3.4 4 0 0 4 4 4 2 Sterile alpha motif (SAM)/Pointed domain Reo_sigmaC PF04582.10 026221.2_32929001_1 - 0.99 8.6 3.9 12 5.0 1.4 2.2 1 1 0 2 2 2 0 Reovirus sigma C capsid protein DUF1640 PF07798.9 026221.2_32929001_1 - 2.2 8.1 16.8 4.6 7.1 16.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) CD20 PF04103.13 001355765.1_32927001_3 - 6.4e-33 113.9 13.8 1.3e-32 112.9 13.8 1.6 1 0 0 1 1 1 1 CD20-like family APOBEC_N PF08210.9 001346000.2_40422001_1 - 3e-57 193.3 3.1 3.6e-57 193.0 3.1 1.1 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001346000.2_40422001_1 - 1.8e-32 111.0 0.9 2.6e-32 110.5 0.1 1.8 2 0 0 2 2 2 1 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 001346000.2_40422001_1 - 0.0069 16.1 0.1 0.01 15.6 0.1 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Toxin-deaminase PF14424.4 001346000.2_40422001_1 - 0.086 12.8 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 The BURPS668_1122 family of deaminases Acyl-CoA_dh_1 PF00441.22 213898.1_49824001_2 - 3.2e-48 163.6 3.2 5.6e-48 162.8 3.2 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.14 213898.1_49824001_2 - 5.5e-36 123.5 0.0 1.3e-35 122.4 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.17 213898.1_49824001_2 - 1.8e-24 85.6 0.0 3.2e-24 84.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.9 213898.1_49824001_2 - 2e-21 76.5 0.6 3.3e-21 75.8 0.6 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain LIM PF00412.20 207222.3_32928001_2 - 3.7e-28 97.4 22.1 8.9e-14 51.3 8.1 2.8 2 0 0 2 2 2 2 LIM domain Acyl-CoA_dh_1 PF00441.22 001110816.1_39725001_1 - 1.2e-48 164.9 4.0 1.9e-48 164.4 4.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.14 001110816.1_39725001_1 - 5.3e-28 97.8 0.1 9.3e-28 97.0 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.17 001110816.1_39725001_1 - 3.6e-27 94.3 0.0 6.8e-27 93.4 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.9 001110816.1_39725001_1 - 3e-20 72.7 1.0 5e-20 72.0 1.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.6 001110816.1_39725001_1 - 0.00014 21.4 0.0 0.00044 19.9 0.0 1.9 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal Misat_Tub_SegII PF10644.7 001350789.1_26226001_2 - 1.3e-31 109.2 0.0 2.1e-31 108.5 0.0 1.3 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.4 001350789.1_26226001_2 - 6.8e-16 58.3 0.0 9.7e-16 57.8 0.0 1.2 1 0 0 1 1 1 1 Tubulin domain Tubulin PF00091.23 001350789.1_26226001_2 - 1.1e-09 38.7 0.0 4.7e-07 30.1 0.0 2.2 2 0 0 2 2 2 2 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.4 001350789.1_26226001_3 - 0.00013 21.6 0.0 0.00022 20.8 0.0 1.2 1 0 0 1 1 1 1 Tubulin domain Acyl-CoA_dh_1 PF00441.22 213897.1_49824001_1 - 2e-41 141.5 0.4 2.8e-41 141.1 0.4 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.14 213897.1_49824001_1 - 2.3e-31 108.6 0.2 5.6e-31 107.4 0.1 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.17 213897.1_49824001_1 - 1.3e-25 89.3 0.0 2.5e-25 88.3 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.9 213897.1_49824001_1 - 1.3e-09 38.3 0.1 1.9e-09 37.8 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.4 213897.1_49824001_1 - 0.042 14.3 0.1 0.099 13.1 0.0 1.7 2 0 0 2 2 2 0 Acyl-coenzyme A oxidase N-terminal DUF4660 PF15559.4 001356284.1_32924001_1 - 5.6e-38 129.4 6.2 5.6e-38 129.4 6.2 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4660) CAF1 PF04857.18 001132198.1_43524001_2 - 1.6e-86 290.3 0.0 9.4e-45 153.0 0.1 2.1 1 1 1 2 2 2 2 CAF1 family ribonuclease zf-CCCH PF00642.22 001132198.1_43524001_2 - 4.1e-06 26.4 0.0 1e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) TFIIS_M PF07500.12 001356343.1_32923001_2 - 2.1e-39 134.2 0.5 3.3e-39 133.6 0.5 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.16 001356343.1_32923001_2 - 5.1e-17 61.3 8.7 1.3e-16 60.0 8.7 1.7 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.9 001356343.1_32923001_2 - 7.9e-14 51.3 1.4 1.8e-13 50.2 1.4 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Baculo_LEF5_C PF11792.6 001356343.1_32923001_2 - 9.9 5.8 7.2 0.84 9.2 2.0 1.9 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain RRM_1 PF00076.20 001257706.1_29623001_2 - 7.2e-24 83.3 0.0 1.1e-23 82.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001257706.1_29623001_2 - 0.0018 18.3 0.0 0.0034 17.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif 7tm_1 PF00001.19 001243677.1_49824001_3 - 5.4e-33 114.2 27.0 9.2e-33 113.5 27.0 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2516 PF10724.7 001243677.1_49824001_3 - 0.091 12.9 1.7 0.16 12.2 0.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2516) ATP-synt_I PF03899.13 001243677.1_49824001_3 - 1.4 9.2 7.3 2.8 8.2 1.9 2.7 2 0 0 2 2 2 0 ATP synthase I chain RRM_1 PF00076.20 001243419.1_49823001_1 - 2.2e-24 84.9 0.0 4.1e-24 84.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001243419.1_49823001_1 - 0.002 18.1 0.0 0.0041 17.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif DUF4660 PF15559.4 151445.1_32924120_1 - 1.9e-21 76.2 0.4 3.2e-21 75.5 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4660) DUF4660 PF15559.4 151445.1_32924120_2 - 6.4e-10 39.2 1.9 1.2e-09 38.2 1.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4660) Ribosomal_L36e PF01158.16 022504.1_45721001_1 - 2.9e-50 168.3 8.8 3.4e-50 168.1 8.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e Cadherin PF00028.15 001007092.1_45729001_3 - 4.3e-17 62.2 0.0 2.8e-09 37.1 0.0 2.7 2 0 0 2 2 2 2 Cadherin domain Laminin_G_3 PF13385.4 001007092.1_45729001_3 - 9.1e-10 38.8 0.0 2.1e-09 37.6 0.0 1.6 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily CDC45 PF02724.12 001007092.1_45729001_3 - 0.00071 17.9 1.2 0.001 17.3 1.2 1.1 1 0 0 1 1 1 1 CDC45-like protein Laminin_G_2 PF02210.22 001007092.1_45729001_3 - 0.0011 19.4 0.0 0.0035 17.8 0.0 1.9 1 0 0 1 1 1 1 Laminin G domain DUF1510 PF07423.9 001007092.1_45729001_3 - 0.0067 15.8 6.5 0.012 15.0 6.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) SpoIIIAH PF12685.5 001007092.1_45729001_3 - 0.013 15.2 1.5 0.025 14.3 1.5 1.4 1 0 0 1 1 1 0 SpoIIIAH-like protein V_ATPase_I PF01496.17 001007092.1_45729001_3 - 0.065 11.0 0.1 0.095 10.5 0.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family UQ_con PF00179.24 001007092.1_45729001_3 - 0.08 12.4 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme Zip PF02535.20 001007092.1_45729001_3 - 0.12 11.4 0.1 0.19 10.8 0.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter EphA2_TM PF14575.4 001007092.1_45729001_3 - 0.15 12.8 0.0 0.44 11.3 0.0 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TRAP_alpha PF03896.14 001007092.1_45729001_3 - 2.6 7.1 5.4 5.8 5.9 5.4 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit FAM176 PF14851.4 001007092.1_45729001_3 - 6.9 6.2 9.0 19 4.8 9.0 1.7 1 1 0 1 1 1 0 FAM176 family 7tm_1 PF00001.19 001001506.1_45722001_1 - 1.3e-12 47.4 22.3 1.3e-12 47.4 22.3 2.0 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001001506.1_45722001_1 - 1.2e-06 27.9 13.7 2.1e-06 27.1 13.7 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx V-set PF07686.15 001009843.2_22422001_1 - 4.4e-13 49.2 0.0 7.4e-13 48.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001009843.2_22422001_1 - 6.2e-05 23.4 0.0 0.00021 21.7 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001009843.2_22422001_1 - 0.00026 21.0 0.1 0.0011 18.9 0.1 1.9 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001009843.2_22422001_1 - 0.012 15.5 0.0 0.038 13.9 0.0 1.7 1 1 0 1 1 1 0 Immunoglobulin I-set domain Ferric_reduct PF01794.17 214305.1_49824001_1 - 3.7e-13 49.6 5.4 3.7e-13 49.6 5.4 2.6 2 1 1 3 3 3 2 Ferric reductase like transmembrane component C1-set PF07654.13 001009284.2_39521001_1 - 2e-23 82.5 0.1 2.4e-23 82.3 0.1 1.1 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001009284.2_39521001_1 - 0.001 19.5 0.0 0.0016 18.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001009284.2_39521001_1 - 0.0019 18.4 0.1 0.0025 18.0 0.1 1.1 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001009284.2_39521001_1 - 0.0072 16.2 0.0 0.0093 15.9 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ank_2 PF12796.5 213922.1_49824001_1 - 7.8e-29 100.0 2.7 5.9e-14 52.3 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 213922.1_49824001_1 - 1.6e-26 91.8 5.5 6.5e-11 42.1 0.2 5.0 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.28 213922.1_49824001_1 - 3.1e-25 87.3 5.7 5.4e-06 26.5 0.0 5.0 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.4 213922.1_49824001_1 - 4.9e-25 87.4 4.8 9.1e-10 38.8 0.1 4.2 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 213922.1_49824001_1 - 8.9e-23 77.8 1.5 0.00018 21.5 0.0 5.6 6 0 0 6 6 6 4 Ankyrin repeat Lipase_3 PF01764.23 001005886.1_45729001_1 - 5.1e-10 39.2 0.0 9.3e-10 38.4 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) EFG_IV PF03764.16 053625.1_45726001_1 - 0.014 15.0 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Elongation factor G, domain IV GTP_EFTU PF00009.25 053625.1_45726001_2 - 4.1e-62 209.0 0.0 5.7e-62 208.6 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.22 053625.1_45726001_2 - 2e-24 85.3 0.0 6.1e-24 83.8 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G C-terminus EFG_IV PF03764.16 053625.1_45726001_2 - 7e-22 77.3 0.0 2.2e-21 75.7 0.0 1.8 2 0 0 2 2 2 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.23 053625.1_45726001_2 - 3.6e-17 62.4 0.1 8.2e-17 61.2 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.4 053625.1_45726001_2 - 2e-15 56.5 0.0 3.8e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.21 053625.1_45726001_2 - 0.0093 15.9 0.1 0.019 14.9 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.14 053625.1_45726001_2 - 0.042 13.0 0.0 0.077 12.2 0.0 1.3 1 0 0 1 1 1 0 AIG1 family CpeT PF06206.9 053625.1_45726001_2 - 0.095 12.5 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 CpeT/CpcT family (DUF1001) EFG_II PF14492.4 053625.1_45726001_3 - 0.001 19.0 0.1 0.002 18.0 0.1 1.4 1 0 0 1 1 1 1 Elongation Factor G, domain II 7tm_1 PF00001.19 214261.1_49824001_1 - 7.8e-73 244.9 6.7 1.2e-72 244.2 6.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 214261.1_49824001_1 - 4.8e-06 26.4 5.4 4.8e-06 26.4 5.4 2.4 2 1 0 3 3 3 1 Olfactory receptor PgaD PF13994.4 214261.1_49824001_1 - 0.054 13.3 0.9 0.2 11.5 0.6 2.0 2 0 0 2 2 2 0 PgaD-like protein ISK_Channel PF02060.13 214261.1_49824001_1 - 0.093 12.3 0.3 0.31 10.6 0.3 1.9 1 0 0 1 1 1 0 Slow voltage-gated potassium channel 7tm_1 PF00001.19 001002280.1_45722001_1 - 1.4e-13 50.5 29.1 2.2e-08 33.6 15.6 2.2 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001002280.1_45722001_1 - 1.8e-10 40.4 14.9 1.8e-10 40.4 14.9 2.4 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srbc PF10316.7 001002280.1_45722001_1 - 0.0015 18.0 10.7 0.0015 18.0 10.7 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc Abhydrolase_9_N PF15420.4 001002280.1_45722001_1 - 0.0025 17.7 4.5 0.0025 17.7 4.5 1.6 2 0 0 2 2 2 1 Alpha/beta-hydrolase family N-terminus TFIIA PF03153.11 001012136.1_45724001_1 - 3.8e-121 405.8 0.0 4.5e-121 405.6 0.0 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit V-set PF07686.15 213756.1_49823001_3 - 1.6e-09 37.8 0.0 2.4e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 213756.1_49823001_3 - 0.00032 21.1 0.7 0.0007 20.0 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 213756.1_49823001_3 - 0.006 16.8 0.0 0.024 14.9 0.0 1.9 1 1 0 1 1 1 1 Immunoglobulin domain Agouti PF05039.10 001011646.1_49822001_1 - 2.1e-28 98.7 15.2 3.5e-28 98.0 15.2 1.3 1 0 0 1 1 1 1 Agouti protein Toxin_9 PF02819.13 001011646.1_49822001_1 - 0.041 14.0 12.9 0.076 13.2 12.9 1.4 1 0 0 1 1 1 0 Spider toxin ETRAMP PF09716.8 001011646.1_49822001_1 - 0.051 13.5 1.2 0.086 12.8 1.2 1.3 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Trypsin PF00089.24 001009169.1_39725001_2 - 1.3e-47 162.4 0.1 2e-47 161.7 0.1 1.3 1 0 0 1 1 1 1 Trypsin VWA PF00092.26 001009169.1_39725001_2 - 3.1e-40 138.1 0.0 5.1e-40 137.5 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Sushi PF00084.18 001009169.1_39725001_2 - 3.6e-26 91.4 18.0 8e-11 42.3 2.7 4.4 4 0 0 4 4 4 3 Sushi repeat (SCR repeat) VWA_2 PF13519.4 001009169.1_39725001_2 - 1.5e-11 44.8 0.0 6.1e-11 42.8 0.0 1.9 1 1 0 1 1 1 1 von Willebrand factor type A domain DUF1986 PF09342.9 001009169.1_39725001_2 - 5.8e-05 23.3 0.0 0.00013 22.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) HRM PF02793.20 001009169.1_39725001_2 - 0.00021 21.4 9.8 1.1 9.4 0.6 3.5 2 1 1 3 3 3 3 Hormone receptor domain Trypsin_2 PF13365.4 001009169.1_39725001_2 - 0.0047 17.7 0.0 0.017 15.8 0.0 1.9 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF758 PF05527.9 001014039.1_45723001_2 - 7.8e-73 244.2 0.0 1.2e-72 243.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF758) MoaE PF02391.15 001014039.1_45723001_2 - 0.038 14.1 0.1 0.076 13.1 0.1 1.4 1 0 0 1 1 1 0 MoaE protein Ribosomal_L13e PF01294.16 031101.1_45722001_1 - 1.8e-82 275.4 5.8 2.4e-82 275.0 5.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e Vinculin PF01044.17 213934.1_49829001_1 - 0 1642.2 38.6 1.5e-298 993.1 16.9 2.0 1 1 1 2 2 2 2 Vinculin family TipAS PF07739.11 213934.1_49829001_1 - 1.1 9.7 11.0 4.7 7.6 0.1 4.7 4 1 0 4 4 4 0 TipAS antibiotic-recognition domain Dynactin_p22 PF07426.9 213934.1_49829001_1 - 7.3 6.3 12.6 3.9 7.2 0.0 4.6 5 0 0 5 5 5 0 Dynactin subunit p22 OCIA PF07051.9 001013874.1_45723001_3 - 3.1e-35 119.9 0.1 5.7e-35 119.1 0.1 1.5 1 0 0 1 1 1 1 Ovarian carcinoma immunoreactive antigen (OCIA) Peptidase_M24 PF00557.22 001004206.1_45724001_1 - 2.5e-25 89.3 0.2 3.5e-25 88.8 0.2 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 TraC PF07820.10 001004206.1_45724001_1 - 0.018 15.2 2.5 0.057 13.6 1.3 2.4 2 0 0 2 2 2 0 TraC-like protein TFIIA_gamma_C PF02751.12 053345.1_45721001_1 - 3.2e-24 84.6 2.5 4.4e-24 84.1 2.5 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.14 053345.1_45721001_1 - 5.4e-24 83.8 0.4 7.6e-24 83.3 0.4 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain Glyco_hydro_18 PF00704.26 207586.2_45724001_3 - 2.3e-98 329.6 1.0 2.7e-98 329.4 1.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_14 PF01607.22 207586.2_45724001_3 - 2.5e-09 37.0 5.7 4.5e-09 36.2 5.7 1.4 1 0 0 1 1 1 1 Chitin binding Peritrophin-A domain Serglycin PF04360.10 207586.2_45724001_3 - 0.1 12.4 0.3 0.19 11.5 0.3 1.4 1 0 0 1 1 1 0 Serglycin Leptin PF02024.13 213840.1_49827001_2 - 2.4e-69 231.6 0.7 3.4e-69 231.1 0.7 1.2 1 0 0 1 1 1 1 Leptin Collagen PF01391.16 214110.1_49823001_2 - 6.9e-28 96.1 110.3 1.5e-09 37.4 23.9 4.6 2 1 2 4 4 4 3 Collagen triple helix repeat (20 copies) Surfac_D-trimer PF09006.9 214110.1_49823001_2 - 8.4e-26 89.5 1.6 4.6e-25 87.1 1.7 2.1 2 0 0 2 2 2 1 Lung surfactant protein D coiled-coil trimerisation Lectin_C PF00059.19 214110.1_49823001_2 - 5.1e-21 75.3 0.1 7.3e-21 74.8 0.1 1.2 1 0 0 1 1 1 1 Lectin C-type domain DUF4982 PF16355.3 214110.1_49823001_2 - 0.015 15.1 0.0 0.051 13.4 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4982) DUF1659 PF07872.9 214110.1_49823001_2 - 0.06 12.9 0.2 0.12 11.9 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1659) Ank_2 PF12796.5 053925.1_45722001_1 - 8.3e-51 170.4 13.6 1.6e-17 63.7 0.1 3.3 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.4 053925.1_45722001_1 - 3.3e-47 158.1 8.1 2.8e-14 53.2 0.0 4.5 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.28 053925.1_45722001_1 - 7.2e-37 124.1 2.3 6.9e-07 29.3 0.3 5.7 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.4 053925.1_45722001_1 - 5.3e-36 118.4 1.5 2.9e-07 30.1 0.0 5.3 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.4 053925.1_45722001_1 - 1.7e-33 114.0 6.8 1e-11 44.7 0.0 5.1 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Cation_ATPase_C PF00689.19 214352.3_49829001_1 - 5.6e-45 153.2 3.7 5.6e-45 153.2 3.7 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.18 214352.3_49829001_1 - 1.8e-37 128.7 13.1 9e-27 93.7 0.9 2.6 3 0 0 3 3 3 2 E1-E2 ATPase ATP_Ca_trans_C PF12424.6 214352.3_49829001_1 - 3.9e-27 94.3 0.2 9.8e-27 93.1 0.2 1.8 1 0 0 1 1 1 1 Plasma membrane calcium transporter ATPase C terminal Cation_ATPase PF13246.4 214352.3_49829001_1 - 7.4e-18 64.3 0.0 1.6e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.24 214352.3_49829001_1 - 7.9e-15 54.2 0.0 2.3e-14 52.6 0.0 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.24 214352.3_49829001_1 - 6e-14 52.7 0.1 1.9e-10 41.2 0.1 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.10 214352.3_49829001_1 - 2.4e-05 24.1 7.0 0.00014 21.5 0.7 2.9 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase DUF2201_N PF13203.4 214352.3_49829001_1 - 0.045 13.2 0.6 0.083 12.3 0.6 1.4 1 0 0 1 1 1 0 Putative metallopeptidase domain Sushi PF00084.18 019301.2_45725001_1 - 6.9e-66 218.6 35.2 1.6e-09 38.1 0.9 7.6 7 1 0 7 7 7 7 Sushi repeat (SCR repeat) PsaN PF05479.9 019301.2_45725001_1 - 4.9e-06 26.6 3.4 0.042 13.9 0.3 2.3 2 0 0 2 2 2 2 Photosystem I reaction centre subunit N (PSAN or PSI-N) cEGF PF12662.5 019301.2_45725001_1 - 2.4 8.0 22.9 10 6.0 0.2 6.5 6 0 0 6 6 6 0 Complement Clr-like EGF-like LRR_4 PF12799.5 001013857.1_45724001_3 - 5.9e-17 61.3 20.3 5.2e-07 29.7 3.7 4.4 3 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001013857.1_45724001_3 - 1.5e-16 60.3 12.4 1.9e-16 59.9 1.2 2.9 2 1 1 3 3 3 2 Leucine-rich repeat LRR_8 PF13855.4 001013857.1_45724001_3 - 1.4e-10 40.6 23.3 1.3e-05 24.7 3.2 3.6 3 0 0 3 3 3 2 Leucine rich repeat LRR_6 PF13516.4 001013857.1_45724001_3 - 0.5 10.4 17.7 7.6 6.7 0.3 5.2 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.31 001013857.1_45724001_3 - 0.6 10.7 16.8 85 4.1 0.9 5.9 4 1 1 5 5 5 0 Leucine Rich Repeat BRCT_assoc PF12820.5 001045493.1_39729001_1 - 5.3e-81 270.1 1.2 5.3e-81 270.1 1.2 3.3 3 0 0 3 3 3 1 Serine-rich domain associated with BRCT BRCT PF00533.24 001045493.1_39729001_1 - 7e-19 67.9 0.0 6.1e-09 36.0 0.0 3.1 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain zf-C3HC4 PF00097.23 001045493.1_39729001_1 - 1.3e-09 37.7 10.7 4.6e-09 35.9 10.7 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001045493.1_39729001_1 - 4.8e-09 35.8 11.1 1.3e-08 34.4 11.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001045493.1_39729001_1 - 9.9e-08 31.9 10.7 3.3e-07 30.2 10.7 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 001045493.1_39729001_1 - 3.5e-07 29.8 7.6 8.7e-07 28.6 7.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001045493.1_39729001_1 - 7.1e-07 29.0 9.0 2.4e-06 27.3 9.0 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 001045493.1_39729001_1 - 2.8e-06 27.4 8.6 2.8e-06 27.4 8.6 2.5 3 0 0 3 3 1 1 Ring finger domain zf-RING_5 PF14634.4 001045493.1_39729001_1 - 1e-05 25.2 8.7 3.5e-05 23.5 8.7 2.0 1 0 0 1 1 1 1 zinc-RING finger domain zf-Nse PF11789.6 001045493.1_39729001_1 - 0.00021 20.9 7.4 0.00056 19.5 7.4 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.4 001045493.1_39729001_1 - 0.00033 20.3 2.1 0.00077 19.2 2.1 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein BRCT_2 PF16589.3 001045493.1_39729001_1 - 0.00048 20.4 0.0 0.32 11.3 0.0 2.8 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain zf-ANAPC11 PF12861.5 001045493.1_39729001_1 - 0.0019 18.1 1.6 0.0046 16.8 1.6 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.4 001045493.1_39729001_1 - 0.0021 17.7 9.2 0.0048 16.6 7.7 2.4 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.3 001045493.1_39729001_1 - 0.0034 17.4 7.0 0.012 15.6 7.0 2.0 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-rbx1 PF12678.5 001045493.1_39729001_1 - 0.012 15.8 5.0 0.051 13.7 5.0 2.2 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.4 001045493.1_39729001_1 - 0.65 9.6 7.1 1.9 8.2 7.1 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Homeobox PF00046.27 023951.1_45722001_1 - 4.2e-21 74.4 0.8 6.2e-21 73.8 0.8 1.2 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 023951.1_45722001_1 - 5.8e-05 22.8 0.2 0.00014 21.5 0.2 1.6 1 0 0 1 1 1 1 Homeobox KN domain His_binding PF02098.14 214064.1_49825001_2 - 0.062 13.2 0.2 0.093 12.6 0.2 1.2 1 0 0 1 1 1 0 Tick histamine binding protein FMO-like PF00743.17 214064.1_49825001_3 - 3e-287 953.1 0.0 3.4e-287 952.9 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.4 214064.1_49825001_3 - 2.3e-16 59.8 0.0 2.9e-12 46.3 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.12 214064.1_49825001_3 - 5.2e-12 45.5 0.0 7.8e-10 38.3 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.4 214064.1_49825001_3 - 9.7e-12 44.5 0.0 8.3e-10 38.2 0.0 2.8 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.4 214064.1_49825001_3 - 4.1e-05 23.6 0.0 8.6e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.25 214064.1_49825001_3 - 7.3e-05 23.1 0.5 0.24 11.9 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 214064.1_49825001_3 - 0.00029 20.5 0.0 0.75 9.2 0.0 2.6 3 0 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.4 214064.1_49825001_3 - 0.0029 17.5 0.0 5.8 6.8 0.0 3.3 3 1 1 4 4 4 2 FAD-NAD(P)-binding Antimicrobial_2 PF08023.10 214064.1_49825001_3 - 0.025 15.0 2.7 0.064 13.7 2.7 1.8 1 0 0 1 1 1 0 Frog antimicrobial peptide AlaDh_PNT_C PF01262.19 214064.1_49825001_3 - 0.027 13.6 0.0 0.44 9.7 0.0 2.1 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.15 214064.1_49825001_3 - 0.11 11.5 0.0 1.5 7.9 0.0 2.1 2 0 0 2 2 2 0 Thi4 family 2-Hacid_dh_C PF02826.17 214064.1_49825001_3 - 0.2 10.9 0.0 2.2 7.4 0.0 2.1 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Kinesin PF00225.21 213626.1_45729001_1 - 6.8e-118 393.3 0.0 4.1e-117 390.7 0.1 2.2 2 0 0 2 2 2 1 Kinesin motor domain DUF3694 PF12473.6 213626.1_45729001_1 - 2e-32 112.8 0.0 2.2e-31 109.4 0.0 2.5 1 1 0 1 1 1 1 Kinesin protein Microtub_bd PF16796.3 213626.1_45729001_1 - 9.7e-28 96.9 0.0 2.5e-27 95.5 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding Kinesin_assoc PF16183.3 213626.1_45729001_1 - 2e-25 89.8 14.4 7.4e-19 68.4 1.1 4.0 2 1 1 3 3 3 2 Kinesin-associated CAP_GLY PF01302.23 213626.1_45729001_1 - 3.9e-23 81.1 1.1 7.9e-23 80.1 1.1 1.5 1 0 0 1 1 1 1 CAP-Gly domain KIF1B PF12423.6 213626.1_45729001_1 - 5.4e-17 61.9 0.4 2.4e-16 59.9 0.4 2.3 1 0 0 1 1 1 1 Kinesin protein 1B FHA PF00498.24 213626.1_45729001_1 - 5.6e-08 32.9 0.1 6.2e-07 29.5 0.0 2.5 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.3 213626.1_45729001_1 - 0.0003 20.9 0.0 0.00096 19.3 0.0 1.8 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain C2-C2_1 PF11618.6 213626.1_45729001_1 - 0.0059 16.6 0.4 0.15 12.0 0.2 3.0 2 1 0 2 2 2 1 First C2 domain of RPGR-interacting protein 1 KMP11 PF03037.14 213626.1_45729001_1 - 0.018 15.7 0.7 0.084 13.5 0.7 2.2 1 0 0 1 1 1 0 Kinetoplastid membrane protein 11 ExsD PF16806.3 213626.1_45729001_1 - 2.9 7.6 9.1 0.14 12.0 2.5 2.1 2 0 0 2 2 2 0 Antiactivator protein ExsD DUF2039 PF10217.7 182505.3_26223001_1 - 3.8e-31 107.2 19.2 8e-31 106.1 19.2 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2039) Cript PF10235.7 182505.3_26223001_1 - 0.21 12.0 17.8 0.91 10.0 17.6 2.2 1 1 0 1 1 1 0 Microtubule-associated protein CRIPT zinc-ribbons_6 PF07191.10 182505.3_26223001_1 - 0.4 10.6 12.5 0.93 9.4 12.5 1.6 1 0 0 1 1 1 0 zinc-ribbons HbrB PF08539.9 001012121.1_45724001_2 - 7.5e-15 55.2 0.4 1.6e-13 50.8 0.2 2.3 1 1 1 2 2 2 2 HbrB-like DUF3720 PF12517.6 001012121.1_45724001_3 - 0.022 15.5 1.6 0.048 14.5 1.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3720) MACPF PF01823.17 080482.2_45725001_3 - 1.1e-06 28.7 0.0 3.5e-06 27.2 0.0 1.9 2 0 0 2 2 2 1 MAC/Perforin domain Homeobox_KN PF05920.9 001009815.1_39723001_1 - 2.3e-17 62.5 0.9 4.3e-17 61.6 0.9 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 001009815.1_39723001_1 - 1.8e-07 30.7 1.2 3.4e-07 29.9 1.2 1.4 1 0 0 1 1 1 1 Homeobox domain Homez PF11569.6 001009815.1_39723001_1 - 0.11 11.9 0.7 0.21 10.9 0.2 1.7 1 1 1 2 2 2 0 Homeodomain leucine-zipper encoding, Homez LRS4 PF10422.7 001009815.1_39723001_1 - 0.55 9.6 2.0 4.9 6.5 0.2 2.2 2 0 0 2 2 2 0 Monopolin complex subunit LRS4 SRP54 PF00448.20 053871.1_45725001_1 - 1.3e-77 259.8 0.8 6.6e-77 257.5 0.1 2.1 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.17 053871.1_45725001_1 - 4.1e-30 104.2 2.8 4.1e-30 104.2 2.8 3.1 2 1 2 4 4 2 1 Signal peptide binding domain SRP54_N PF02881.17 053871.1_45725001_1 - 6e-21 74.3 3.1 1.5e-20 73.1 3.1 1.7 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.17 053871.1_45725001_1 - 1.1e-06 28.3 0.7 1.1e-05 25.0 0.7 2.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.4 053871.1_45725001_1 - 2.1e-05 24.6 0.0 3.9e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain CbiA PF01656.21 053871.1_45725001_1 - 9.8e-05 22.3 0.0 0.00034 20.5 0.0 1.9 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain DUF2209 PF09974.7 053871.1_45725001_1 - 0.0002 21.5 0.3 0.00049 20.3 0.3 1.6 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2209) AAA_17 PF13207.4 053871.1_45725001_1 - 0.00064 20.0 0.7 0.0024 18.2 0.1 2.4 2 1 0 2 2 1 1 AAA domain SRPRB PF09439.8 053871.1_45725001_1 - 0.00066 19.0 0.6 0.7 9.2 0.0 2.5 1 1 0 2 2 2 2 Signal recognition particle receptor beta subunit ArgK PF03308.14 053871.1_45725001_1 - 0.0012 17.8 0.1 0.022 13.6 0.0 2.3 2 0 0 2 2 2 1 ArgK protein AAA_22 PF13401.4 053871.1_45725001_1 - 0.0025 18.0 0.1 0.019 15.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.4 053871.1_45725001_1 - 0.011 15.3 0.0 0.031 13.9 0.0 1.7 2 0 0 2 2 1 0 AAA domain AAA_31 PF13614.4 053871.1_45725001_1 - 0.014 15.2 0.6 0.043 13.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.21 053871.1_45725001_1 - 0.019 14.9 1.6 0.054 13.5 0.2 2.4 2 1 0 2 2 2 0 50S ribosome-binding GTPase APS_kinase PF01583.18 053871.1_45725001_1 - 0.02 14.7 0.0 0.038 13.8 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase ResIII PF04851.13 053871.1_45725001_1 - 0.024 14.5 0.1 0.056 13.3 0.1 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit MobB PF03205.12 053871.1_45725001_1 - 0.054 13.3 0.1 0.17 11.7 0.0 1.9 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.4 053871.1_45725001_1 - 0.056 13.7 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.4 053871.1_45725001_1 - 0.067 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.4 053871.1_45725001_1 - 0.079 13.3 0.1 0.2 12.1 0.1 1.8 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.15 053871.1_45725001_1 - 0.14 11.8 2.7 0.28 10.8 0.1 2.6 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA PF00004.27 053871.1_45725001_1 - 0.18 12.1 1.7 1.5 9.1 0.1 3.1 2 2 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) EMP24_GP25L PF01105.22 053467.1_45723001_1 - 5.7e-47 159.9 0.0 7.2e-47 159.5 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Myelin_MBP PF01669.15 001025101.1_26226001_1 - 2.5e-69 232.6 8.4 2.5e-69 232.6 8.4 2.0 2 0 0 2 2 2 1 Myelin basic protein DNA_topoisoIV PF00521.18 213884.1_49829001_2 - 1.8e-133 445.4 0.1 5.4e-133 443.8 0.0 1.8 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.3 213884.1_49829001_2 - 2e-50 170.2 5.4 6e-50 168.7 5.4 1.9 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.23 213884.1_49829001_2 - 1.8e-27 95.8 1.5 3.9e-27 94.7 1.5 1.6 1 0 0 1 1 1 1 DNA gyrase B DTHCT PF08070.9 213884.1_49829001_2 - 3.9e-20 72.4 15.1 3.9e-20 72.4 15.1 5.8 2 1 3 5 5 5 1 DTHCT (NUC029) region HATPase_c PF02518.24 213884.1_49829001_2 - 6.8e-16 58.7 0.1 2.8e-15 56.7 0.0 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.20 213884.1_49829001_2 - 2e-09 37.5 0.0 4.9e-09 36.2 0.0 1.7 1 0 0 1 1 1 1 Toprim domain DUF2693 PF10902.6 213884.1_49829001_2 - 0.071 13.0 1.4 2.4 8.1 1.3 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2693) Glutaredoxin PF00462.22 001013034.1_45723001_2 - 1.2e-17 63.7 0.2 1.8e-17 63.2 0.2 1.3 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.4 001013034.1_45723001_2 - 0.012 15.6 0.1 0.02 14.8 0.1 1.3 1 0 0 1 1 1 0 Thioredoxin domain Thioredoxin_2 PF13098.4 001013034.1_45723001_2 - 0.12 12.8 0.1 0.19 12.1 0.1 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain Pkinase_Tyr PF07714.15 001007798.1_45724001_1 - 1.1e-93 313.2 0.1 1.4e-93 312.8 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001007798.1_45724001_1 - 5.2e-46 157.0 0.0 7.8e-46 156.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 001007798.1_45724001_1 - 1.4e-21 76.1 0.1 3.4e-21 75.0 0.1 1.7 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 001007798.1_45724001_1 - 1.7e-16 59.4 0.1 3.9e-16 58.3 0.1 1.6 1 0 0 1 1 1 1 SH3 domain PH PF00169.27 001007798.1_45724001_1 - 2.6e-13 50.2 1.1 6.4e-12 45.8 0.1 3.4 3 2 0 3 3 3 1 PH domain BTK PF00779.17 001007798.1_45724001_1 - 4.9e-13 48.5 1.8 1e-12 47.5 1.8 1.6 1 0 0 1 1 1 1 BTK motif SH3_9 PF14604.4 001007798.1_45724001_1 - 1.3e-08 34.4 0.1 2.7e-08 33.4 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001007798.1_45724001_1 - 1.3e-05 24.6 0.0 3.6e-05 23.2 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Kinase-like PF14531.4 001007798.1_45724001_1 - 0.00027 20.2 0.0 0.00072 18.8 0.0 1.7 2 0 0 2 2 2 1 Kinase-like SH3_3 PF08239.9 001007798.1_45724001_1 - 0.00032 20.8 0.1 0.0007 19.7 0.1 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain Kdo PF06293.12 001007798.1_45724001_1 - 0.02 14.1 0.1 0.037 13.2 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001007798.1_45724001_1 - 0.021 14.6 0.0 0.037 13.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family hSH3 PF14603.4 001007798.1_45724001_1 - 0.037 14.4 0.0 0.12 12.8 0.0 1.8 1 0 0 1 1 1 0 Helically-extended SH3 domain SH3_4 PF06347.11 001007798.1_45724001_1 - 0.073 12.8 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain CN_hydrolase PF00795.20 214133.1_49824001_3 - 1.4e-15 57.2 0.0 2.2e-15 56.6 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase RRM_1 PF00076.20 001014015.1_45726001_3 - 1.5e-28 98.3 1.3 2.3e-16 59.3 0.0 3.4 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001014015.1_45726001_3 - 4e-08 33.1 0.0 0.004 17.1 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif RRM_occluded PF16842.3 001014015.1_45726001_3 - 0.00019 21.1 0.1 0.85 9.4 0.0 3.3 2 1 0 2 2 2 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.4 001014015.1_45726001_3 - 0.018 14.8 0.0 3.2 7.7 0.0 2.5 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Thymidylat_synt PF00303.17 019179.1_45724001_1 - 2.7e-117 390.6 0.0 3.2e-117 390.3 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase Topoisom_I PF01028.18 022615.1_45725001_1 - 1.1e-101 338.8 2.0 1.1e-101 338.8 2.0 2.4 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.13 022615.1_45725001_1 - 2.3e-101 337.6 6.8 2.3e-101 337.6 6.8 4.9 4 1 0 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.4 022615.1_45725001_1 - 1.3e-35 120.9 0.6 1.3e-34 117.8 0.6 2.9 1 0 0 1 1 1 1 C-terminal topoisomerase domain TGFb_propeptide PF00688.16 013107.1_45724001_1 - 1.2e-100 336.2 0.1 1.7e-100 335.7 0.1 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 013107.1_45724001_1 - 2.1e-37 128.0 1.3 4.2e-37 127.1 1.3 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain MARVEL PF01284.21 001014263.1_45722001_3 - 6.9e-43 146.0 7.5 8.8e-43 145.7 7.5 1.1 1 0 0 1 1 1 1 Membrane-associating domain PDZ PF00595.22 001012086.1_45724001_3 - 1.1e-12 48.0 0.0 2.3e-12 46.9 0.0 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001012086.1_45724001_3 - 0.00034 20.7 0.0 0.0044 17.2 0.0 2.2 2 0 0 2 2 2 1 PDZ domain GRASP55_65 PF04495.12 001012086.1_45724001_3 - 0.057 13.6 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 GRASP55/65 PDZ-like domain G6B PF15096.4 001012086.1_45724001_3 - 0.13 11.9 0.1 0.2 11.2 0.1 1.3 1 0 0 1 1 1 0 G6B family Glyco_transf_64 PF09258.8 020097.1_45727001_2 - 2e-100 335.0 0.3 3.5e-100 334.3 0.1 1.5 2 0 0 2 2 2 1 Glycosyl transferase family 64 domain Exostosin PF03016.13 020097.1_45727001_2 - 5.8e-59 199.6 0.0 9.7e-59 198.9 0.0 1.3 1 0 0 1 1 1 1 Exostosin family TPR_MLP1_2 PF07926.10 020097.1_45727001_2 - 0.0067 16.4 5.9 0.0067 16.4 5.9 1.5 2 0 0 2 2 1 1 TPR/MLP1/MLP2-like protein ADIP PF11559.6 020097.1_45727001_2 - 0.021 14.8 7.2 0.048 13.6 7.2 1.5 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF1664 PF07889.10 020097.1_45727001_2 - 0.028 14.3 1.8 0.059 13.2 1.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Seryl_tRNA_N PF02403.20 020097.1_45727001_2 - 0.05 13.7 4.6 0.092 12.9 4.6 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Bap31 PF05529.10 020097.1_45727001_2 - 0.051 13.1 0.1 0.088 12.3 0.1 1.4 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like THOC7 PF05615.11 020097.1_45727001_2 - 0.057 13.6 5.2 0.03 14.5 1.9 2.0 2 0 0 2 2 2 0 Tho complex subunit 7 DUF812 PF05667.9 020097.1_45727001_2 - 0.1 11.3 2.3 0.16 10.7 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) EzrA PF06160.10 020097.1_45727001_2 - 0.14 10.2 3.3 0.21 9.6 3.3 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Tropomyosin_1 PF12718.5 020097.1_45727001_2 - 0.14 12.1 4.1 0.27 11.2 4.1 1.3 1 0 0 1 1 1 0 Tropomyosin like Jnk-SapK_ap_N PF09744.7 020097.1_45727001_2 - 0.17 12.0 4.6 0.17 12.0 3.1 1.7 2 0 0 2 2 1 0 JNK_SAPK-associated protein-1 Atg14 PF10186.7 020097.1_45727001_2 - 0.34 9.8 4.5 0.57 9.1 4.5 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMPIT PF07851.11 020097.1_45727001_2 - 0.49 9.4 3.6 1 8.4 3.6 1.4 1 0 0 1 1 1 0 TMPIT-like protein Med9 PF07544.11 020097.1_45727001_2 - 0.56 10.2 4.9 14 5.7 3.4 2.5 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 BRE1 PF08647.9 020097.1_45727001_2 - 0.77 9.7 7.4 1.4 8.9 7.4 1.3 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase DUF724 PF05266.12 020097.1_45727001_2 - 0.93 9.2 3.5 1.7 8.3 3.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF342 PF03961.11 020097.1_45727001_2 - 1 7.8 2.5 1.5 7.2 2.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Spc7 PF08317.9 020097.1_45727001_2 - 1.1 8.0 6.1 1.8 7.2 6.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein IncA PF04156.12 020097.1_45727001_2 - 2.1 8.0 6.7 4.1 7.0 6.7 1.4 1 0 0 1 1 1 0 IncA protein YlqD PF11068.6 020097.1_45727001_2 - 4.1 7.7 6.4 7.7 6.8 6.4 1.3 1 0 0 1 1 1 0 YlqD protein UBA_4 PF14555.4 001017445.1_45724001_1 - 1.7e-06 27.6 1.4 1.8e-06 27.5 0.2 1.7 2 0 0 2 2 2 1 UBA-like domain UBX PF00789.18 001017445.1_45724001_1 - 2.2e-05 24.4 0.2 8.3e-05 22.6 0.2 2.0 1 1 0 1 1 1 1 UBX domain DUF1682 PF07946.12 001017445.1_45724001_1 - 0.0013 17.9 10.3 0.0024 17.0 10.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) Thioredoxin_7 PF13899.4 001017445.1_45724001_1 - 0.045 13.8 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like PEHE PF15275.4 001017445.1_45724001_1 - 1.6 9.3 11.7 0.32 11.5 7.8 1.8 1 1 0 1 1 1 0 PEHE domain AAA_23 PF13476.4 001017445.1_45724001_1 - 3.9 7.8 13.0 11 6.3 13.0 1.8 1 0 0 1 1 1 0 AAA domain TPR_1 PF00515.26 138911.3_45725001_3 - 1.4e-55 182.9 45.1 8.4e-08 31.6 0.3 9.6 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_2 PF07719.15 138911.3_45725001_3 - 1.5e-45 149.6 36.6 1.4e-06 27.8 0.4 9.6 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_11 PF13414.4 138911.3_45725001_3 - 3.2e-28 97.0 23.6 1.3e-08 34.2 0.1 7.2 5 2 2 7 7 7 5 TPR repeat TPR_8 PF13181.4 138911.3_45725001_3 - 9.8e-25 84.5 39.5 0.0012 18.8 0.4 10.2 10 0 0 10 10 9 8 Tetratricopeptide repeat TPR_12 PF13424.4 138911.3_45725001_3 - 1.5e-22 79.5 22.5 8.8e-11 41.8 0.1 8.0 5 2 1 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.4 138911.3_45725001_3 - 1.1e-17 63.1 5.9 0.14 12.9 0.0 8.3 4 3 4 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.4 138911.3_45725001_3 - 1.5e-17 63.9 11.0 0.00076 20.0 0.0 6.3 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_19 PF14559.4 138911.3_45725001_3 - 1.2e-14 54.5 18.1 0.012 16.0 0.1 6.7 5 1 0 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.4 138911.3_45725001_3 - 2e-14 52.7 16.4 0.00017 21.6 0.5 7.6 8 0 0 8 8 6 3 Tetratricopeptide repeat TPR_7 PF13176.4 138911.3_45725001_3 - 2.4e-12 45.8 22.7 0.018 14.9 0.0 9.3 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_9 PF13371.4 138911.3_45725001_3 - 1e-11 44.7 0.2 0.0068 16.4 0.0 4.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.4 138911.3_45725001_3 - 6.5e-08 32.1 18.7 0.99 9.2 0.0 8.8 9 0 0 9 9 9 2 Tetratricopeptide repeat NARP1 PF12569.6 138911.3_45725001_3 - 5.5e-07 28.7 24.2 0.0014 17.5 0.2 5.0 2 2 3 5 5 5 4 NMDA receptor-regulated protein 1 TPR_6 PF13174.4 138911.3_45725001_3 - 3.5e-05 24.0 24.0 2.9 8.6 0.0 8.7 9 0 0 9 9 8 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 138911.3_45725001_3 - 0.0013 18.6 24.8 1 9.3 0.4 7.8 7 1 1 8 8 7 2 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.5 138911.3_45725001_3 - 0.0014 18.7 25.3 0.018 15.1 2.4 5.3 3 3 2 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 DnaI_N PF07319.9 138911.3_45725001_3 - 0.0024 18.3 1.2 1.6 9.3 0.2 3.6 1 1 2 3 3 3 1 Primosomal protein DnaI N-terminus TPR_20 PF14561.4 138911.3_45725001_3 - 0.0067 16.6 5.4 0.56 10.5 0.1 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_3 PF07720.10 138911.3_45725001_3 - 0.0086 15.9 27.6 0.55 10.2 0.1 7.6 7 0 0 7 7 7 1 Tetratricopeptide repeat DREPP PF05558.10 138911.3_45725001_3 - 0.13 12.0 6.9 1.8 8.3 0.1 3.4 3 0 0 3 3 3 0 DREPP plasma membrane polypeptide Alkyl_sulf_dimr PF14863.4 138911.3_45725001_3 - 0.17 12.2 4.8 1.7 9.0 0.0 3.8 3 2 0 3 3 3 0 Alkyl sulfatase dimerisation MIT PF04212.16 138911.3_45725001_3 - 0.2 11.6 37.8 0.4 10.7 1.1 8.3 7 1 1 8 8 8 0 MIT (microtubule interacting and transport) domain Wtap PF17098.3 138911.3_45725001_3 - 0.54 10.1 6.4 0.33 10.8 0.2 2.9 3 0 0 3 3 3 0 WTAP/Mum2p family Sel1 PF08238.10 138911.3_45725001_3 - 0.78 10.4 6.2 31 5.3 0.2 5.2 6 0 0 6 6 4 0 Sel1 repeat DUF5113 PF17140.2 138911.3_45725001_3 - 0.92 9.2 14.0 1.9 8.2 0.2 4.8 5 1 0 5 5 5 0 Domain of unknown function (DUF5113) TOM20_plant PF06552.10 138911.3_45725001_3 - 1 8.9 5.1 7.7 6.1 0.3 3.6 3 1 0 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 MAS20 PF02064.13 138911.3_45725001_3 - 1.4 8.9 9.3 9.9 6.1 0.5 4.3 3 1 0 4 4 3 0 MAS20 protein import receptor Mtc PF03820.15 001012213.1_45725001_3 - 2.9e-150 499.4 1.3 4.5e-150 498.8 1.3 1.3 1 0 0 1 1 1 1 Tricarboxylate carrier BSD PF03909.15 001012213.1_45725001_3 - 0.028 14.3 0.1 0.23 11.3 0.0 2.2 2 0 0 2 2 2 0 BSD domain MBOAT PF03062.17 031118.1_45724001_2 - 1.7e-65 221.5 38.4 2.2e-65 221.1 38.4 1.1 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Na_K-ATPase PF00287.16 001009796.1_39526001_1 - 2.3e-99 332.0 0.5 3.4e-99 331.5 0.5 1.1 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain zf-piccolo PF05715.11 001110797.1_45729001_2 - 1.9e-56 187.9 32.4 1.9e-29 101.4 12.9 2.5 2 0 0 2 2 2 2 Piccolo Zn-finger C2 PF00168.28 001110797.1_45729001_2 - 1.2e-23 83.2 0.1 3.1e-23 81.9 0.1 1.7 1 0 0 1 1 1 1 C2 domain PDZ PF00595.22 001110797.1_45729001_2 - 8.7e-08 32.3 0.1 3.1e-07 30.5 0.1 2.0 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) FYVE_2 PF02318.14 001110797.1_45729001_2 - 1.7e-05 24.9 13.7 0.00019 21.5 3.2 4.6 5 0 0 5 5 5 2 FYVE-type zinc finger Pyridoxal_deC PF00282.17 213894.1_49827001_3 - 5.5e-152 505.7 0.0 6.8e-152 505.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.17 213894.1_49827001_3 - 1.9e-05 23.7 0.0 0.00015 20.7 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.19 213894.1_49827001_3 - 3.5e-05 23.1 0.0 5.5e-05 22.5 0.0 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.15 213894.1_49827001_3 - 0.032 13.4 0.0 0.046 12.9 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family SepSecS PF05889.11 213894.1_49827001_3 - 0.037 12.6 0.0 0.056 12.0 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS OKR_DC_1 PF01276.18 213894.1_49827001_3 - 0.066 11.8 0.0 0.099 11.2 0.0 1.1 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain TAS2R PF05296.11 023997.1_45722001_1 - 2.6e-107 358.3 40.1 3e-107 358.1 40.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) SHNi-TPR PF10516.7 001005543.1_45726001_1 - 3.2e-14 52.0 4.3 1.4e-13 49.9 2.0 2.7 2 0 0 2 2 2 1 SHNi-TPR TPR_2 PF07719.15 001005543.1_45726001_1 - 1.2e-09 37.4 2.8 0.014 15.4 0.1 4.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.4 001005543.1_45726001_1 - 4.9e-09 36.2 10.1 1.7e-08 34.5 4.0 3.4 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.26 001005543.1_45726001_1 - 2.7e-08 33.1 2.5 0.00092 18.8 0.1 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 001005543.1_45726001_1 - 4.6e-05 23.2 4.8 0.24 11.6 0.1 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.4 001005543.1_45726001_1 - 0.0093 16.6 3.4 0.19 12.5 0.1 4.1 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.4 001005543.1_45726001_1 - 0.039 13.7 2.7 5.8 6.8 0.0 4.1 4 2 1 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.4 001005543.1_45726001_1 - 0.04 14.4 1.8 20 6.0 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.4 001005543.1_45726001_1 - 0.049 14.2 2.4 19 5.9 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.4 001005543.1_45726001_1 - 0.071 12.7 4.4 36 4.0 1.9 4.6 2 1 2 4 4 4 0 TPR repeat TGFb_propeptide PF00688.16 001009400.1_39523001_1 - 8.5e-37 127.1 0.0 1.1e-36 126.7 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001009400.1_39523001_1 - 1.6e-22 80.2 1.6 3.3e-22 79.2 1.6 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain Sterile PF03015.17 001009400.1_39523001_1 - 0.15 12.2 0.1 0.56 10.3 0.0 1.9 2 0 0 2 2 2 0 Male sterility protein MARVEL PF01284.21 012798.1_45725001_1 - 5.6e-14 52.3 19.9 9.3e-14 51.5 19.9 1.4 1 0 0 1 1 1 1 Membrane-associating domain Ig_3 PF13927.4 020081.1_45722001_1 - 5.3e-06 26.8 0.2 0.17 12.4 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 020081.1_45722001_1 - 9.7e-06 25.6 0.7 6.3e-05 23.0 0.1 2.4 3 0 0 3 3 3 1 Immunoglobulin V-set domain C2-set_2 PF08205.10 020081.1_45722001_1 - 0.00015 21.6 0.0 0.00038 20.3 0.0 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain V-set_CD47 PF08204.9 020081.1_45722001_1 - 0.014 15.2 0.2 0.17 11.7 0.0 2.6 2 1 1 3 3 3 0 CD47 immunoglobulin-like domain I-set PF07679.14 020081.1_45722001_1 - 0.028 14.4 0.0 0.069 13.1 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin I-set domain PCYCGC PF13798.4 020081.1_45722001_1 - 0.056 13.2 0.0 0.093 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function with PCYCGC motif CoA_trans PF01144.21 001012221.1_45724001_3 - 1.1e-114 381.2 0.5 1.2e-68 230.6 0.0 2.0 2 0 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.4 001012221.1_45724001_3 - 0.022 14.6 0.0 0.038 13.8 0.0 1.3 1 0 0 1 1 1 0 Acetyl-CoA hydrolase/transferase C-terminal domain Asp PF00026.21 021753.1_45723001_3 - 1.2e-110 369.7 0.0 1.4e-110 369.5 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 021753.1_45723001_3 - 1.1e-14 55.0 0.3 1.3e-08 35.2 0.1 2.4 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 021753.1_45723001_3 - 9.3e-10 38.0 1.1 1.6e-09 37.3 1.1 1.4 1 0 0 1 1 1 1 A1 Propeptide Nbs1_C PF08599.8 138873.2_45726001_3 - 5e-32 109.8 0.2 1.9e-31 107.9 0.2 2.1 1 0 0 1 1 1 1 DNA damage repair protein Nbs1 NIBRIN_BRCT_II PF16508.3 138873.2_45726001_3 - 2.7e-30 105.0 0.0 5.9e-30 103.9 0.0 1.6 1 0 0 1 1 1 1 Second BRCT domain on Nijmegen syndrome breakage protein FHA PF00498.24 138873.2_45726001_3 - 2.6e-14 53.2 0.1 6.1e-14 52.0 0.1 1.7 1 0 0 1 1 1 1 FHA domain RTT107_BRCT_5 PF16770.3 138873.2_45726001_3 - 2.1e-05 24.2 0.0 7.1e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain Yop-YscD_cpl PF16697.3 138873.2_45726001_3 - 2.3e-05 24.5 0.0 0.00017 21.7 0.0 2.3 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain BRCT PF00533.24 138873.2_45726001_3 - 0.00064 20.0 0.0 0.012 15.9 0.0 2.6 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain IspD PF01128.17 001008386.1_45726001_3 - 9.3e-40 136.6 0.0 1.4e-39 136.0 0.0 1.3 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NTP_transf_3 PF12804.5 001008386.1_45726001_3 - 1.5e-09 38.2 0.1 3e-09 37.3 0.1 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain WD40 PF00400.30 001009686.2_45726001_3 - 1.4e-21 76.2 16.4 5.2e-05 23.8 0.7 7.5 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001009686.2_45726001_3 - 2.7e-07 30.6 0.1 0.35 11.1 0.0 5.4 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain SIT PF15330.4 001024344.1_45723001_1 - 0.00011 22.4 0.0 0.0004 20.7 0.0 1.9 1 1 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT fn3 PF00041.19 031048.1_45727001_2 - 1.2e-21 76.7 8.9 4.7e-06 26.7 0.4 6.4 7 0 0 7 7 7 4 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 031048.1_45727001_2 - 5e-05 23.7 0.4 5e-05 23.7 0.4 3.5 4 0 0 4 4 4 1 Purple acid Phosphatase, N-terminal domain IL6Ra-bind PF09240.8 031048.1_45727001_2 - 0.0012 19.1 1.8 0.15 12.4 0.0 3.2 3 0 0 3 3 3 1 Interleukin-6 receptor alpha chain, binding PhoD_N PF16655.3 031048.1_45727001_2 - 0.09 13.2 0.0 0.27 11.7 0.0 1.7 1 0 0 1 1 1 0 PhoD-like phosphatase, N-terminal domain DUF3827 PF12877.5 031048.1_45727001_2 - 0.15 10.3 0.7 0.3 9.3 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) PI-PLC-X PF00388.17 053758.2_45729001_3 - 7e-59 197.4 0.0 1.5e-58 196.4 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.17 053758.2_45729001_3 - 2.5e-34 118.0 0.0 1.9e-32 111.9 0.0 2.7 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain RasGEF PF00617.17 053758.2_45729001_3 - 3.2e-22 79.4 0.1 7.9e-22 78.1 0.1 1.7 1 0 0 1 1 1 1 RasGEF domain RA PF00788.21 053758.2_45729001_3 - 1.2e-20 73.8 0.3 5.3e-20 71.7 0.1 2.2 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain C2 PF00168.28 053758.2_45729001_3 - 9.6e-09 35.3 0.0 1.9e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 C2 domain EF-hand_like PF09279.9 053758.2_45729001_3 - 0.00025 21.3 0.0 0.0014 19.0 0.0 2.3 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like Calx-beta PF03160.12 001009848.1_22427001_3 - 7.7e-65 215.2 11.0 1.2e-35 121.5 1.5 2.7 3 0 0 3 3 3 2 Calx-beta domain Na_Ca_ex PF01699.22 001009848.1_22427001_3 - 8.9e-63 210.7 30.3 1.6e-35 122.2 11.3 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Na_Ca_ex_C PF16494.3 001009848.1_22427001_3 - 4.8e-51 172.4 5.8 9.1e-51 171.5 5.8 1.5 1 0 0 1 1 1 1 C-terminal extension of sodium/calcium exchanger domain DnaG_DnaB_bind PF08278.9 001009848.1_22427001_3 - 0.037 14.5 1.8 0.084 13.3 1.8 1.5 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding Ribosomal_S10 PF00338.20 001008859.1_45722001_2 - 7.8e-24 83.6 0.1 1.1e-23 83.1 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e CRISPR_Cse2 PF09485.8 001008859.1_45722001_2 - 0.058 13.8 0.0 0.098 13.0 0.0 1.4 1 0 0 1 1 1 0 CRISPR-associated protein Cse2 (CRISPR_cse2) F-box-like PF12937.5 001008859.1_45722001_2 - 0.14 11.9 0.1 0.53 10.1 0.1 2.0 2 0 0 2 2 2 0 F-box-like Img2 PF05046.12 001047883.1_45722001_2 - 1.5e-27 95.5 0.0 2e-27 95.1 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) Reticulon PF02453.15 201562.3_45724001_1 - 1.8e-42 144.8 3.9 2.3e-42 144.5 3.9 1.1 1 0 0 1 1 1 1 Reticulon STAT_bind PF02864.13 001009402.1_39526001_1 - 3.2e-101 338.2 3.4 3.2e-101 338.2 3.4 2.2 2 0 0 2 2 2 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 001009402.1_39526001_1 - 5.3e-44 150.1 24.0 5.3e-44 150.1 24.0 1.7 2 0 0 2 2 2 1 STAT protein, all-alpha domain STAT_int PF02865.15 001009402.1_39526001_1 - 3.3e-37 127.5 0.9 3.3e-37 127.5 0.9 3.1 4 1 0 4 4 4 1 STAT protein, protein interaction domain SH2 PF00017.22 001009402.1_39526001_1 - 7e-13 48.3 0.2 1.3e-11 44.2 0.0 2.9 3 0 0 3 3 3 1 SH2 domain Ras PF00071.20 001010953.1_45723001_1 - 4.4e-38 130.3 0.0 5.6e-38 130.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001010953.1_45723001_1 - 7e-19 68.1 0.0 1e-18 67.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001010953.1_45723001_1 - 9.1e-07 28.4 0.0 1.4e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MARVEL PF01284.21 144673.2_26223001_2 - 3.7e-09 36.6 3.9 3.7e-09 36.6 3.9 1.5 2 0 0 2 2 2 1 Membrane-associating domain GWT1 PF06423.10 144673.2_26223001_2 - 0.0063 16.5 0.5 0.012 15.6 0.5 1.4 1 0 0 1 1 1 1 GWT1 Bap31 PF05529.10 001004224.1_45723001_2 - 8.5e-78 260.4 5.0 1.1e-77 260.0 5.0 1.2 1 0 0 1 1 1 1 B-cell receptor-associated protein 31-like DUF996 PF06195.11 001004224.1_45723001_2 - 0.03 14.5 1.1 0.058 13.5 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF996) Imm3 PF14425.4 001004224.1_45723001_2 - 0.063 13.2 1.5 0.1 12.5 1.5 1.3 1 0 0 1 1 1 0 Immunity protein Imm3 DUF4407 PF14362.4 001004224.1_45723001_2 - 0.074 12.3 5.2 0.11 11.6 5.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NicO PF03824.14 001004224.1_45723001_2 - 0.17 11.1 2.0 0.7 9.0 0.1 2.2 1 1 1 2 2 2 0 High-affinity nickel-transport protein APG6 PF04111.10 001004224.1_45723001_2 - 0.2 10.9 12.9 0.31 10.2 12.9 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Rootletin PF15035.4 001004224.1_45723001_2 - 0.28 11.1 9.1 1.4 8.8 3.4 2.3 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion CENP-H PF05837.10 001004224.1_45723001_2 - 0.31 11.3 13.0 0.055 13.8 6.7 2.1 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Spc7 PF08317.9 001004224.1_45723001_2 - 0.42 9.3 13.2 0.55 8.9 13.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Cpta_toxin PF07254.10 001004224.1_45723001_2 - 0.44 10.4 2.9 4.3 7.2 2.9 2.2 1 1 0 1 1 1 0 Membrane-bound toxin component of toxin-antitoxin system IncA PF04156.12 001004224.1_45723001_2 - 0.47 10.1 11.9 0.99 9.0 11.9 1.6 1 1 0 1 1 1 0 IncA protein DUF3498 PF12004.6 001004224.1_45723001_2 - 0.61 9.1 7.6 0.82 8.6 7.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3498) Atg14 PF10186.7 001004224.1_45723001_2 - 0.74 8.7 7.2 1.1 8.1 7.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF730 PF05325.9 001004224.1_45723001_2 - 1.3 8.9 4.8 1.6 8.6 3.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF730) Lebercilin PF15619.4 001004224.1_45723001_2 - 1.5 8.3 18.1 0.19 11.2 11.7 2.0 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Sec34 PF04136.13 001004224.1_45723001_2 - 2 8.2 10.7 0.19 11.4 4.2 2.0 2 0 0 2 2 2 0 Sec34-like family JIP_LZII PF16471.3 001004224.1_45723001_2 - 4.8 7.3 13.2 6.7 6.8 0.1 3.2 3 1 0 3 3 3 0 JNK-interacting protein leucine zipper II DUF972 PF06156.11 001004224.1_45723001_2 - 7.1 7.2 12.3 28 5.3 3.5 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF972) MBD PF01429.17 001011924.1_45725001_2 - 6.4e-17 60.9 0.0 1.3e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 Methyl-CpG binding domain zf-CXXC PF02008.18 001011924.1_45725001_2 - 6.2e-09 35.6 17.7 6.2e-09 35.6 17.7 2.6 2 0 0 2 2 2 1 CXXC zinc finger domain Stathmin PF00836.17 053440.2_45724001_3 - 3e-55 185.8 22.5 4.7e-55 185.1 22.5 1.3 1 0 0 1 1 1 1 Stathmin family Ribosomal_S8e PF01201.20 009098.2_32922001_3 - 4.4e-63 211.4 1.0 5.3e-63 211.1 1.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e ubiquitin PF00240.21 001009286.1_39521001_1 - 1.1e-34 117.8 0.3 1.5e-34 117.4 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.15 001009286.1_39521001_1 - 7.9e-33 111.9 12.3 1.2e-32 111.3 12.3 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.6 001009286.1_39521001_1 - 7.4e-17 60.8 0.4 1.2e-16 60.1 0.4 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 001009286.1_39521001_1 - 9.8e-06 25.8 0.1 3.2e-05 24.1 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 001009286.1_39521001_1 - 0.0078 16.2 0.0 0.016 15.1 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 001009286.1_39521001_1 - 0.071 13.5 0.1 0.085 13.3 0.1 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain F-box-like PF12937.5 022272.1_45722001_1 - 1.5e-13 50.3 0.6 5.5e-13 48.4 0.6 1.9 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.4 022272.1_45722001_1 - 1.4e-10 40.2 15.3 0.043 13.7 0.0 6.8 7 0 0 7 7 7 3 Leucine Rich repeat LRR_4 PF12799.5 022272.1_45722001_1 - 6.3e-10 39.0 6.2 0.021 15.1 0.1 4.5 3 1 0 4 4 4 3 Leucine Rich repeats (2 copies) F-box PF00646.31 022272.1_45722001_1 - 1.1e-07 31.4 0.7 1.1e-07 31.4 0.7 2.1 2 0 0 2 2 2 1 F-box domain LRR_1 PF00560.31 022272.1_45722001_1 - 0.003 17.7 9.6 4.6 8.0 0.3 6.1 5 1 0 5 5 5 1 Leucine Rich Repeat F-box_4 PF15966.3 022272.1_45722001_1 - 0.0054 16.5 0.0 0.0054 16.5 0.0 2.3 3 0 0 3 3 3 1 F-box LRR_8 PF13855.4 022272.1_45722001_1 - 0.011 15.3 1.3 0.14 11.8 0.3 3.3 3 2 1 4 4 4 0 Leucine rich repeat PAP2_C PF14360.4 001012040.1_45724001_3 - 1.3e-26 92.7 10.1 1.3e-26 92.7 10.1 2.9 3 0 0 3 3 3 1 PAP2 superfamily C-terminal SAM_1 PF00536.28 001012040.1_45724001_3 - 1.9e-09 37.7 0.0 3.2e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PAP2 PF01569.19 001012040.1_45724001_3 - 0.0017 18.0 10.2 0.0017 18.0 10.2 1.9 2 1 0 2 2 2 1 PAP2 superfamily SAM_PNT PF02198.14 001012040.1_45724001_3 - 0.0029 17.4 0.0 0.027 14.3 0.0 2.5 3 0 0 3 3 3 1 Sterile alpha motif (SAM)/Pointed domain SAM_2 PF07647.15 001012040.1_45724001_3 - 0.007 16.3 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PAP2_3 PF14378.4 001012040.1_45724001_3 - 0.19 11.3 15.7 0.077 12.5 13.2 1.7 1 1 1 2 2 2 0 PAP2 superfamily Adaptin_N PF01602.18 080781.2_45727001_2 - 9.8e-124 413.6 9.7 1.5e-123 413.1 9.7 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.4 080781.2_45727001_2 - 1.1e-62 209.5 0.1 6.8e-62 207.0 0.0 2.2 2 0 0 2 2 2 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.10 080781.2_45727001_2 - 1.6e-60 203.0 0.3 3.3e-60 201.9 0.3 1.6 1 0 0 1 1 1 1 Coatomer beta C-terminal region Cnd1 PF12717.5 080781.2_45727001_2 - 1.2e-07 31.7 13.7 1.2e-05 25.2 0.2 4.2 2 1 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.20 080781.2_45727001_2 - 1.3e-07 31.1 0.1 0.023 14.8 0.0 5.0 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.4 080781.2_45727001_2 - 1.5e-07 31.6 4.5 0.029 14.6 0.0 5.9 4 2 3 7 7 7 2 HEAT repeats HEAT_EZ PF13513.4 080781.2_45727001_2 - 2.2e-06 27.8 0.8 0.53 10.7 0.0 5.2 5 0 0 5 5 5 2 HEAT-like repeat MMS19_N PF14500.4 080781.2_45727001_2 - 0.0004 19.9 5.0 0.00085 18.8 0.0 3.4 3 1 2 5 5 5 1 Dos2-interacting transcription regulator of RNA-Pol-II Arm PF00514.21 080781.2_45727001_2 - 0.00067 19.5 0.1 2 8.4 0.0 3.9 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat GDA1_CD39 PF01150.15 199394.1_45724001_3 - 3.2e-76 256.6 0.0 1.2e-75 254.7 0.0 1.8 1 1 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family KH_1 PF00013.27 001013223.1_45724001_2 - 3.2e-49 164.5 15.8 6.7e-18 64.2 0.8 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.15 001013223.1_45724001_2 - 2.7e-14 52.6 6.4 8.9e-05 22.1 0.0 3.4 3 1 0 3 3 3 3 KH domain KH_4 PF13083.4 001013223.1_45724001_2 - 2.9e-06 26.9 4.2 0.2 11.4 0.5 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.4 001013223.1_45724001_2 - 0.00016 21.5 6.8 0.59 10.1 0.1 3.3 3 0 0 3 3 3 3 NusA-like KH domain MOEP19 PF16005.3 001013223.1_45724001_2 - 0.094 12.6 0.0 0.69 9.8 0.0 2.3 3 0 0 3 3 3 0 KH-like RNA-binding domain Lamp PF01299.15 001014183.1_45724001_2 - 3.3e-22 79.3 0.2 5e-22 78.7 0.2 1.2 1 0 0 1 1 1 1 Lysosome-associated membrane glycoprotein (Lamp) ATP-synt_S1 PF05827.10 001014183.1_45724001_2 - 5.4e-06 26.1 0.1 1.2e-05 25.0 0.1 1.6 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) Chordopox_A13L PF05961.9 001014183.1_45724001_2 - 0.03 14.4 0.1 0.065 13.4 0.1 1.5 1 0 0 1 1 1 0 Chordopoxvirus A13L protein 7tm_1 PF00001.19 053303.1_45723001_1 - 1.2e-50 172.1 14.2 2.2e-50 171.3 14.2 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 053303.1_45723001_1 - 0.00048 19.8 14.1 0.0011 18.7 14.1 1.5 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 053303.1_45723001_1 - 0.0014 17.9 12.3 0.0022 17.3 12.3 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF4059 PF13268.4 053303.1_45723001_1 - 0.11 12.8 7.4 0.67 10.3 0.7 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF4059) 7TM_GPCR_Srx PF10328.7 053303.1_45723001_1 - 0.62 9.2 10.6 0.038 13.2 4.6 1.8 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx TctB PF07331.9 053303.1_45723001_1 - 0.76 9.9 16.3 1.7 8.8 10.5 2.7 1 1 1 2 2 2 0 Tripartite tricarboxylate transporter TctB family zf-H2C2_2 PF13465.4 001012471.1_45728001_3 - 7.9e-28 95.5 75.8 1.6e-06 28.2 3.8 12.4 12 0 0 12 12 12 7 Zinc-finger double domain BTB PF00651.29 001012471.1_45728001_3 - 1.5e-21 76.5 0.1 3e-21 75.6 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 001012471.1_45728001_3 - 1.4e-18 66.0 79.1 4e-05 23.7 0.8 10.8 10 0 0 10 10 10 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001012471.1_45728001_3 - 6.3e-18 63.8 82.2 0.019 15.6 0.5 11.2 11 0 0 11 11 11 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001012471.1_45728001_3 - 1.8e-12 46.7 52.6 0.026 14.3 1.4 9.4 9 0 0 9 9 9 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001012471.1_45728001_3 - 1.3e-11 44.4 47.7 0.00018 21.6 0.1 9.6 10 0 0 10 10 10 4 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.3 001012471.1_45728001_3 - 0.0001 22.4 1.5 0.0001 22.4 1.5 5.4 3 2 2 5 5 5 2 C2H2-type zinc ribbon zf-C2H2_11 PF16622.3 001012471.1_45728001_3 - 0.00074 19.1 0.2 0.00074 19.1 0.2 6.2 7 0 0 7 7 7 2 zinc-finger C2H2-type zf-C2HC_2 PF13913.4 001012471.1_45728001_3 - 0.0015 18.2 28.8 0.037 13.8 0.3 7.7 7 0 0 7 7 7 2 zinc-finger of a C2HC-type zf-met PF12874.5 001012471.1_45728001_3 - 0.0016 18.7 0.7 0.0016 18.7 0.7 8.7 8 0 0 8 8 8 3 Zinc-finger of C2H2 type RNA_pol_Rpb6 PF01192.20 031335.3_45721001_1 - 1.2e-15 57.0 0.2 1.2e-15 57.0 0.2 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb6 BDHCT_assoc PF16204.3 031335.3_45721001_1 - 2.3 7.7 3.6 3 7.3 3.6 1.2 1 0 0 1 1 1 0 BDHCT-box associated domain on Bloom syndrome protein DIE2_ALG10 PF04922.10 139101.2_45725001_2 - 1e-131 439.6 26.2 1.3e-131 439.3 26.2 1.1 1 0 0 1 1 1 1 DIE2/ALG10 family Cpn60_TCP1 PF00118.22 001004078.1_45724001_3 - 9.3e-158 525.7 5.6 1.1e-157 525.5 5.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FancD2 PF14631.4 001001719.1_45729001_1 - 0 2473.7 34.1 0 2473.5 34.1 1.0 1 0 0 1 1 1 1 Fanconi anaemia protein FancD2 nuclease FANCI_S2 PF14676.4 001001719.1_45729001_1 - 9.5e-06 25.8 4.1 2.6e-05 24.4 1.4 3.5 2 1 0 2 2 2 1 FANCI solenoid 2 Cadherin PF00028.15 001037137.1_45729001_1 - 6.7e-81 266.7 0.1 6.5e-16 58.4 0.1 6.4 5 1 1 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001037137.1_45729001_1 - 1.7e-34 117.3 0.1 2.8e-32 110.2 0.0 4.1 5 0 0 5 5 5 1 Cadherin-like Cadherin_tail PF15974.3 001037137.1_45729001_1 - 8.7e-26 90.7 2.8 1.6e-25 89.8 2.8 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 001037137.1_45729001_1 - 5.3e-24 84.7 0.6 1.4e-23 83.4 0.6 1.8 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001037137.1_45729001_1 - 8.1e-06 25.7 3.3 1.4 8.8 0.2 4.7 4 0 0 4 4 4 2 Cadherin-like IL12p40_C PF10420.7 214013.1_49825001_3 - 4.4e-22 78.2 1.4 9.9e-22 77.1 0.3 2.1 2 0 0 2 2 2 1 Cytokine interleukin-12p40 C-terminus Ig_3 PF13927.4 214013.1_49825001_3 - 9.4e-06 26.0 1.0 0.00018 21.9 0.1 2.7 2 0 0 2 2 2 1 Immunoglobulin domain Ig_5 PF16681.3 214013.1_49825001_3 - 3.9e-05 23.9 0.2 0.00017 21.8 0.0 2.1 1 1 1 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 214013.1_49825001_3 - 0.00015 21.9 0.4 0.0006 20.0 0.0 2.2 2 0 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain Ig_2 PF13895.4 214013.1_49825001_3 - 0.00037 20.6 0.4 0.0044 17.2 0.0 2.6 2 1 1 3 3 3 1 Immunoglobulin domain fn3 PF00041.19 214013.1_49825001_3 - 0.027 14.7 0.2 0.21 11.8 0.2 2.4 2 0 0 2 2 2 0 Fibronectin type III domain Zona_pellucida PF00100.21 001009330.2_22423001_1 - 3.6e-41 141.5 0.0 4.4e-41 141.2 0.0 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain zf-DHHC PF01529.18 133394.1_45726001_2 - 2.1e-35 121.6 14.2 2.1e-35 121.6 14.2 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase Stathmin PF00836.17 001009582.1_49822001_3 - 6.8e-60 200.8 28.5 8e-60 200.6 28.5 1.0 1 0 0 1 1 1 1 Stathmin family CCDC84 PF14968.4 001009582.1_49822001_3 - 0.13 11.8 7.2 0.15 11.6 7.2 1.1 1 0 0 1 1 1 0 Coiled coil protein 84 Ribonuc_2-5A PF06479.10 001009582.1_49822001_3 - 0.21 11.6 7.2 0.34 10.9 7.2 1.3 1 0 0 1 1 1 0 Ribonuclease 2-5A Exonuc_VII_L PF02601.13 001009582.1_49822001_3 - 2.8 7.3 11.2 3.7 6.9 11.2 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Mitofilin PF09731.7 001009582.1_49822001_3 - 3.8 6.1 22.6 4.3 5.9 22.6 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein WTX PF09422.8 001009582.1_49822001_3 - 4.5 6.1 13.7 5.7 5.8 13.7 1.0 1 0 0 1 1 1 0 WTX protein DUF3584 PF12128.6 001009582.1_49822001_3 - 5.4 4.3 18.4 7 3.9 18.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) MerR-DNA-bind PF09278.9 001009582.1_49822001_3 - 9.4 6.7 9.1 0.85 10.1 1.2 2.2 2 0 0 2 2 2 0 MerR, DNA binding 7tm_1 PF00001.19 001009288.1_22425001_1 - 3.3e-29 101.8 23.1 6.3e-29 100.9 23.1 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.4 001009288.1_22425001_1 - 2.7e-19 68.5 1.2 7.5e-06 25.5 0.1 4.5 2 2 2 4 4 4 4 Leucine rich repeat LRR_5 PF13306.4 001009288.1_22425001_1 - 1.7e-12 47.3 1.8 3.5e-06 26.9 0.2 2.6 2 1 0 2 2 2 2 Leucine rich repeats (6 copies) Peptidase_M9_N PF08453.8 001009288.1_22425001_1 - 0.042 13.4 0.2 0.08 12.5 0.2 1.4 1 0 0 1 1 1 0 Peptidase family M9 N-terminal Asp PF00026.21 001002802.1_45724001_1 - 4.9e-45 154.2 0.0 7.7e-45 153.5 0.0 1.3 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.4 001002802.1_45724001_1 - 1.6e-12 47.3 0.0 2.5e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal TAXi_N PF14543.4 001002802.1_45724001_1 - 4.3e-07 30.2 0.2 0.0011 19.2 0.0 2.3 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal FHA PF00498.24 001014044.1_45724001_2 - 8e-06 26.0 0.0 1.2e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 FHA domain Carboxyl_trans PF01039.20 001012177.1_45725001_1 - 1.6e-151 505.2 0.0 1.6e-151 505.2 0.0 1.7 2 0 0 2 2 2 1 Carboxyl transferase domain Reprolysin PF01421.17 001014772.1_45727001_1 - 1.1e-71 240.7 0.0 1.1e-71 240.7 0.0 1.7 2 0 0 2 2 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 001014772.1_45727001_1 - 2.9e-32 111.3 4.1 2.9e-32 111.3 4.1 3.2 3 0 0 3 3 1 1 ADAM cysteine-rich Pep_M12B_propep PF01562.17 001014772.1_45727001_1 - 8.6e-31 106.9 0.5 1.5e-30 106.2 0.5 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide Disintegrin PF00200.21 001014772.1_45727001_1 - 2.7e-20 72.8 27.0 2.7e-20 72.8 27.0 4.4 4 1 0 4 4 3 1 Disintegrin Reprolysin_5 PF13688.4 001014772.1_45727001_1 - 4.7e-20 72.4 0.1 1.1e-19 71.2 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 001014772.1_45727001_1 - 4.1e-15 56.3 0.0 7.1e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 001014772.1_45727001_1 - 1.6e-11 44.1 0.0 2.5e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 001014772.1_45727001_1 - 6.4e-10 39.1 0.1 1.1e-09 38.3 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.11 001014772.1_45727001_1 - 0.0051 17.0 13.1 0.0051 17.0 13.1 5.2 5 1 1 6 6 3 1 EGF-like domain Peptidase_M57 PF12388.6 001014772.1_45727001_1 - 0.023 14.2 0.3 0.04 13.4 0.3 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Peptidase_M66 PF10462.7 001014772.1_45727001_1 - 0.024 13.4 0.2 0.041 12.7 0.2 1.3 1 0 0 1 1 1 0 Peptidase M66 Peptidase_M10 PF00413.22 001014772.1_45727001_1 - 0.031 14.0 0.0 0.049 13.3 0.0 1.2 1 0 0 1 1 1 0 Matrixin Tropomyosin PF00261.18 214335.1_49822001_1 - 1e-93 312.9 59.2 1.2e-93 312.7 59.2 1.0 1 0 0 1 1 1 1 Tropomyosin Tropomyosin_1 PF12718.5 214335.1_49822001_1 - 3.5e-24 85.4 58.1 4.3e-20 72.2 25.6 3.3 1 1 0 2 2 2 2 Tropomyosin like Laminin_II PF06009.10 214335.1_49822001_1 - 1.5e-05 24.9 29.4 6.1e-05 22.9 8.3 3.4 1 1 3 4 4 4 2 Laminin Domain II DUF3450 PF11932.6 214335.1_49822001_1 - 0.00081 18.6 9.5 0.00081 18.6 9.5 3.0 1 1 3 4 4 4 1 Protein of unknown function (DUF3450) TMF_DNA_bd PF12329.6 214335.1_49822001_1 - 0.0048 16.7 15.3 0.0048 16.7 15.3 5.5 2 1 2 5 5 5 2 TATA element modulatory factor 1 DNA binding XhlA PF10779.7 214335.1_49822001_1 - 0.0051 16.9 36.9 0.038 14.1 1.4 5.7 3 2 3 6 6 6 3 Haemolysin XhlA CCDC144C PF14915.4 214335.1_49822001_1 - 0.0052 15.8 40.5 0.041 12.9 4.7 3.1 1 1 1 2 2 2 1 CCDC144C protein coiled-coil region CENP-F_leu_zip PF10473.7 214335.1_49822001_1 - 0.0066 16.3 52.6 0.019 14.8 31.7 2.6 2 1 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PspA_IM30 PF04012.10 214335.1_49822001_1 - 0.019 14.4 5.3 0.019 14.4 5.3 3.2 1 1 2 3 3 2 0 PspA/IM30 family CLZ PF16526.3 214335.1_49822001_1 - 0.023 14.9 5.1 0.023 14.9 5.1 4.9 1 1 4 5 5 5 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels FPP PF05911.9 214335.1_49822001_1 - 0.024 12.8 42.5 0.19 9.8 34.1 2.3 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil BST2 PF16716.3 214335.1_49822001_1 - 0.027 14.9 10.2 0.027 14.9 10.2 4.4 1 1 4 5 5 4 0 Bone marrow stromal antigen 2 HrpB7 PF09486.8 214335.1_49822001_1 - 0.032 14.5 44.7 0.082 13.2 5.2 3.3 1 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) CALCOCO1 PF07888.9 214335.1_49822001_1 - 0.034 12.6 43.5 0.048 12.1 43.5 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Uds1 PF15456.4 214335.1_49822001_1 - 0.04 14.0 38.9 2.6 8.1 0.9 5.1 1 1 2 4 4 4 0 Up-regulated During Septation DUF1664 PF07889.10 214335.1_49822001_1 - 0.056 13.3 23.6 0.079 12.8 2.7 3.5 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) TSC22 PF01166.16 214335.1_49822001_1 - 0.072 13.3 1.0 0.072 13.3 1.0 3.4 3 1 1 4 4 2 0 TSC-22/dip/bun family MscS_porin PF12795.5 214335.1_49822001_1 - 0.08 12.3 41.3 1.1 8.6 20.8 3.1 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Reo_sigmaC PF04582.10 214335.1_49822001_1 - 0.11 11.7 4.1 0.13 11.5 1.0 2.0 1 1 2 3 3 3 0 Reovirus sigma C capsid protein DUF724 PF05266.12 214335.1_49822001_1 - 0.12 12.1 41.3 0.25 11.0 6.6 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF724) Jnk-SapK_ap_N PF09744.7 214335.1_49822001_1 - 0.12 12.4 52.9 4.7 7.3 23.9 2.8 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Fib_alpha PF08702.8 214335.1_49822001_1 - 0.25 11.4 23.8 0.39 10.7 6.5 2.9 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Golgin_A5 PF09787.7 214335.1_49822001_1 - 0.27 10.5 45.0 0.34 10.2 14.8 2.8 1 1 2 3 3 3 0 Golgin subfamily A member 5 DUF745 PF05335.11 214335.1_49822001_1 - 0.27 10.8 39.1 0.67 9.5 8.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Alanine_zipper PF11839.6 214335.1_49822001_1 - 0.28 11.3 37.3 0.76 10.0 2.3 4.5 1 1 2 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein EzrA PF06160.10 214335.1_49822001_1 - 0.39 8.7 37.2 0.59 8.1 6.1 2.1 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA ADIP PF11559.6 214335.1_49822001_1 - 0.59 10.1 41.3 0.061 13.3 11.3 3.8 1 1 4 5 5 5 0 Afadin- and alpha -actinin-Binding TPR_MLP1_2 PF07926.10 214335.1_49822001_1 - 0.93 9.4 56.3 1.3 9.0 19.5 4.2 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein GAS PF13851.4 214335.1_49822001_1 - 0.99 8.6 47.5 0.091 12.0 5.8 3.1 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding IncA PF04156.12 214335.1_49822001_1 - 1 9.0 50.6 1.3e+02 2.1 25.1 3.0 1 1 1 2 2 2 0 IncA protein ATG16 PF08614.9 214335.1_49822001_1 - 1.2 9.1 50.3 1.6 8.7 8.9 3.5 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Lebercilin PF15619.4 214335.1_49822001_1 - 1.4 8.4 52.1 0.51 9.8 13.3 3.2 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DUF948 PF06103.9 214335.1_49822001_1 - 1.5 9.0 15.1 0.75 10.0 0.4 4.2 2 1 3 5 5 5 0 Bacterial protein of unknown function (DUF948) SNARE PF05739.17 214335.1_49822001_1 - 1.7 8.6 5.3 1.5 8.7 0.1 3.1 3 1 0 3 3 2 0 SNARE domain Exonuc_VII_L PF02601.13 214335.1_49822001_1 - 2 7.8 30.4 2.9 7.3 14.9 2.1 1 1 1 2 2 2 0 Exonuclease VII, large subunit NPV_P10 PF05531.10 214335.1_49822001_1 - 2.3 8.6 17.8 3 8.3 0.5 4.5 2 2 2 4 4 4 0 Nucleopolyhedrovirus P10 protein Hormone_1 PF00103.18 214335.1_49822001_1 - 2.5 7.6 10.3 0.086 12.4 2.3 2.2 2 0 0 2 2 2 0 Somatotropin hormone family Snapin_Pallidin PF14712.4 214335.1_49822001_1 - 2.8 8.3 32.1 2 8.8 1.3 4.9 1 1 3 5 5 5 0 Snapin/Pallidin TraF_2 PF13729.4 214335.1_49822001_1 - 2.9 7.1 8.3 4.9 6.3 0.7 2.3 2 1 0 2 2 2 0 F plasmid transfer operon, TraF, protein AAA_13 PF13166.4 214335.1_49822001_1 - 3.6 6.0 36.8 1.8 7.0 2.7 2.1 1 1 1 2 2 2 0 AAA domain DUF16 PF01519.14 214335.1_49822001_1 - 4.3 7.7 35.1 0.41 11.0 2.0 4.0 1 1 3 4 4 4 0 Protein of unknown function DUF16 FliJ PF02050.14 214335.1_49822001_1 - 5 7.2 43.5 11 6.1 10.6 3.0 1 1 2 3 3 3 0 Flagellar FliJ protein HMMR_N PF15905.3 214335.1_49822001_1 - 5.5 6.2 46.9 1.8 7.8 10.3 2.3 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal FH2 PF02181.21 214335.1_49822001_1 - 5.7 5.8 29.2 0.9 8.5 9.3 2.9 1 1 2 3 3 3 0 Formin Homology 2 Domain Flagellin_N PF00669.18 214335.1_49822001_1 - 6.5 6.7 16.7 3.7 7.5 1.2 3.6 1 1 2 4 4 4 0 Bacterial flagellin N-terminal helical region APG6 PF04111.10 214335.1_49822001_1 - 6.5 5.9 48.4 1.6 7.9 23.7 2.5 1 1 2 3 3 3 0 Autophagy protein Apg6 Fez1 PF06818.13 214335.1_49822001_1 - 6.8 7.0 43.6 22 5.3 26.9 2.8 1 1 1 2 2 2 0 Fez1 Noelin-1 PF12308.6 214335.1_49822001_1 - 8.8 6.2 15.5 6.2 6.7 0.4 3.9 1 1 5 6 6 6 0 Neurogenesis glycoprotein Myosin_head PF00063.19 214021.1_49829001_1 - 1.1e-236 787.2 4.8 1.1e-236 787.2 4.8 1.7 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin-VI_CBD PF16521.3 214021.1_49829001_1 - 7.1e-44 147.7 0.3 5.4e-43 144.9 0.0 2.7 3 0 0 3 3 3 1 Myosin VI cargo binding domain Myosin_N PF02736.17 214021.1_49829001_1 - 0.0007 19.2 0.0 0.0014 18.3 0.0 1.5 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain IQ PF00612.25 214021.1_49829001_1 - 0.0071 15.9 1.2 0.021 14.4 1.2 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif BUD22 PF09073.8 214021.1_49829001_1 - 0.011 15.0 27.7 0.018 14.3 27.7 1.3 1 0 0 1 1 1 0 BUD22 PseudoU_synth_2 PF00849.20 214021.1_49829001_1 - 0.64 10.0 5.3 2.2 8.2 5.3 1.9 1 0 0 1 1 1 0 RNA pseudouridylate synthase AAA_16 PF13191.4 214021.1_49829001_1 - 0.68 10.1 0.0 0.68 10.1 0.0 2.9 3 1 0 3 3 3 0 AAA ATPase domain Sec20 PF03908.11 214021.1_49829001_1 - 0.71 9.7 4.6 2.5 8.0 4.6 2.0 1 0 0 1 1 1 0 Sec20 MFS_1 PF07690.14 033055.2_26226001_1 - 3.9e-32 111.4 36.8 2.1e-31 109.0 36.3 2.2 2 1 0 2 2 2 1 Major Facilitator Superfamily Ras PF00071.20 001013430.1_45724001_1 - 1.7e-43 147.9 0.0 2.2e-43 147.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001013430.1_45724001_1 - 2.5e-22 79.2 0.0 4.2e-22 78.5 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001013430.1_45724001_1 - 3.8e-07 29.6 0.0 5.6e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001013430.1_45724001_1 - 0.021 14.8 0.0 0.039 13.9 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase Trypsin PF00089.24 001005349.1_49825001_3 - 1.9e-57 194.5 0.2 3.6e-57 193.6 0.0 1.5 2 0 0 2 2 2 1 Trypsin CUB PF00431.18 001005349.1_49825001_3 - 2.1e-43 147.0 0.4 1.5e-22 79.9 0.0 2.4 2 0 0 2 2 2 2 CUB domain Sushi PF00084.18 001005349.1_49825001_3 - 1.2e-14 54.5 8.6 5.1e-07 30.1 1.3 2.9 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) FXa_inhibition PF14670.4 001005349.1_49825001_3 - 9e-10 38.5 7.1 3.6e-09 36.6 7.1 2.1 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site Trypsin_2 PF13365.4 001005349.1_49825001_3 - 3.9e-06 27.7 0.0 9.2e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Trypsin-like peptidase domain EGF_CA PF07645.13 001005349.1_49825001_3 - 6.2e-06 26.2 9.8 3.2e-05 23.9 9.8 2.3 1 0 0 1 1 1 1 Calcium-binding EGF domain CUB_2 PF02408.18 001005349.1_49825001_3 - 0.00045 19.8 0.3 0.25 11.0 0.1 2.5 2 0 0 2 2 2 2 CUB-like domain EGF PF00008.25 001005349.1_49825001_3 - 0.013 15.7 8.4 0.083 13.1 8.4 2.5 1 0 0 1 1 1 0 EGF-like domain HRM PF02793.20 001005349.1_49825001_3 - 0.17 12.1 12.2 0.17 12.1 1.3 3.3 3 0 0 3 3 3 0 Hormone receptor domain hEGF PF12661.5 001005349.1_49825001_3 - 0.3 11.7 7.9 0.17 12.5 3.5 3.1 2 0 0 2 2 2 0 Human growth factor-like EGF Trypsin PF00089.24 001003956.1_45722001_1 - 2.2e-43 148.5 0.0 2.7e-43 148.2 0.0 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 001003956.1_45722001_1 - 0.00053 20.2 0.0 0.00081 19.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) EF-hand_6 PF13405.4 214318.2_49823001_1 - 2e-12 45.8 0.0 0.0085 15.8 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.30 214318.2_49823001_1 - 3.7e-12 44.7 0.4 0.0099 15.2 0.0 4.5 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.4 214318.2_49823001_1 - 5e-08 32.5 1.0 7.6e-06 25.5 0.2 3.4 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_7 PF13499.4 214318.2_49823001_1 - 4.2e-07 30.2 0.6 0.71 10.3 0.0 3.4 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 214318.2_49823001_1 - 3.9e-06 26.0 0.1 0.41 10.1 0.0 3.8 3 0 0 3 3 3 2 EF hand eIF-1a PF01176.17 001008773.2_45724001_3 - 4.3e-20 71.1 0.1 6.9e-20 70.5 0.1 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Ribosomal_L35Ae PF01247.16 021264.3_45721001_2 - 6.4e-48 160.8 0.3 7.2e-48 160.6 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.16 021264.3_45721001_2 - 0.011 15.8 0.0 0.91 9.7 0.0 2.1 2 0 0 2 2 2 0 RimM N-terminal domain DUF2080 PF09853.7 021264.3_45721001_2 - 0.047 13.3 0.2 0.21 11.2 0.0 2.2 2 1 1 3 3 3 0 Putative transposon-encoded protein (DUF2080) fn3 PF00041.19 001003929.1_45723001_3 - 9.3e-08 32.2 0.4 2.5e-07 30.8 0.4 1.8 1 0 0 1 1 1 1 Fibronectin type III domain Ig_3 PF13927.4 001003929.1_45723001_3 - 0.0003 21.2 2.1 0.00084 19.8 0.0 2.6 3 0 0 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.4 001003929.1_45723001_3 - 0.00067 19.8 0.1 0.002 18.3 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001003929.1_45723001_3 - 0.00086 19.3 0.1 0.12 12.4 0.0 2.7 3 0 0 3 3 3 1 Immunoglobulin domain Ig_5 PF16681.3 001003929.1_45723001_3 - 0.0017 18.6 0.0 0.0037 17.5 0.0 1.5 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Mucin PF01456.15 001003929.1_45723001_3 - 5.5 6.8 16.6 6.7 6.6 9.9 2.4 2 0 0 2 2 2 0 Mucin-like glycoprotein Pkinase PF00069.23 031617.1_45723001_1 - 4.4e-27 95.0 0.0 5.5e-27 94.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 031617.1_45723001_1 - 6e-17 61.7 0.0 7.5e-17 61.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 031617.1_45723001_1 - 0.00017 21.5 0.2 0.0014 18.5 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.9 031617.1_45723001_1 - 0.042 12.7 0.1 0.07 12.0 0.1 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.12 031617.1_45723001_1 - 0.096 11.9 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Cyt-b5 PF00173.26 001007671.1_45723001_2 - 1.7e-10 40.7 0.1 3.3e-10 39.8 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glyco_transf_43 PF03360.14 054003.1_45725001_3 - 1.6e-74 250.1 0.0 2.1e-74 249.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 43 NHL PF01436.19 031786.1_45726001_2 - 2.6e-49 162.7 21.6 1.1e-09 37.7 0.2 6.7 6 0 0 6 6 6 6 NHL repeat Filamin PF00630.17 031786.1_45726001_2 - 1.4e-17 64.3 0.0 3.6e-17 63.0 0.0 1.7 1 0 0 1 1 1 1 Filamin/ABP280 repeat DUF5128 PF17170.2 031786.1_45726001_2 - 7.4e-16 58.1 2.2 5.2e-07 29.0 0.1 3.6 1 1 3 4 4 4 4 6-bladed beta-propeller SGL PF08450.10 031786.1_45726001_2 - 7.4e-14 51.8 4.0 5.4e-05 22.8 0.0 4.9 1 1 3 4 4 4 3 SMP-30/Gluconolaconase/LRE-like region zf-B_box PF00643.22 031786.1_45726001_2 - 1.3e-10 41.1 2.5 1.3e-10 41.1 2.5 2.7 2 1 0 2 2 1 1 B-box zinc finger zf-RING_UBOX PF13445.4 031786.1_45726001_2 - 1.1e-07 31.6 9.7 1.1e-07 31.6 9.7 2.2 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 031786.1_45726001_2 - 2.7e-06 27.0 12.6 2.7e-06 27.0 12.6 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 031786.1_45726001_2 - 3.3e-06 26.7 10.6 3.3e-06 26.7 10.6 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 031786.1_45726001_2 - 4.9e-06 26.3 10.9 4.9e-06 26.3 10.9 2.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 031786.1_45726001_2 - 7.2e-06 26.0 12.7 7.2e-06 26.0 12.7 2.2 2 0 0 2 2 1 1 Ring finger domain DUF4934 PF16288.3 031786.1_45726001_2 - 1.3e-05 24.9 1.1 0.14 12.0 0.3 3.3 2 1 1 3 3 3 3 Domain of unknown function (DUF4934) zf-C3HC4_2 PF13923.4 031786.1_45726001_2 - 2.1e-05 24.1 12.7 2.1e-05 24.1 12.7 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) SBBP PF06739.9 031786.1_45726001_2 - 6.5e-05 22.7 1.8 0.69 9.8 0.4 3.4 3 0 0 3 3 3 1 Beta-propeller repeat Prok-RING_4 PF14447.4 031786.1_45726001_2 - 0.0026 17.5 11.3 0.0026 17.5 11.3 2.2 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.3 031786.1_45726001_2 - 0.12 12.0 4.5 0.42 10.3 4.5 2.0 1 0 0 1 1 1 0 RING-like zinc finger Apolipoprotein PF01442.16 031786.1_45726001_2 - 0.13 12.1 7.5 0.23 11.2 7.5 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain CENP-F_leu_zip PF10473.7 031786.1_45726001_2 - 0.13 12.1 2.4 0.23 11.3 2.4 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Invasin_D3 PF09134.8 031786.1_45726001_2 - 0.14 11.7 0.0 0.4 10.3 0.0 1.7 1 0 0 1 1 1 0 Invasin, domain 3 YojJ PF10372.7 031786.1_45726001_2 - 0.27 11.2 1.6 1.3 9.1 0.7 2.2 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus VCBS PF13517.4 031786.1_45726001_2 - 0.29 11.6 6.5 10 6.6 0.2 4.3 3 2 2 5 5 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Baculo_PEP_C PF04513.10 031786.1_45726001_2 - 0.41 10.5 2.2 1 9.3 2.2 1.6 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus zf-ANAPC11 PF12861.5 031786.1_45726001_2 - 0.67 9.9 9.3 0.024 14.6 3.2 1.8 2 0 0 2 2 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.4 031786.1_45726001_2 - 8.6 6.5 25.2 0.026 14.6 14.9 2.2 2 0 0 2 2 1 0 zinc finger of C3HC4-type, RING IRK PF01007.18 214151.1_49823001_1 - 3.2e-156 519.2 1.7 3.9e-156 518.9 1.7 1.0 1 0 0 1 1 1 1 Inward rectifier potassium channel IRK_N PF08466.8 214151.1_49823001_1 - 3e-26 91.2 0.7 6.4e-26 90.1 0.7 1.6 1 0 0 1 1 1 1 Inward rectifier potassium channel N-terminal Ion_trans_2 PF07885.14 214151.1_49823001_1 - 8e-05 22.4 5.5 0.00017 21.3 5.5 1.6 1 0 0 1 1 1 1 Ion channel Ion_trans PF00520.29 214151.1_49823001_1 - 0.019 14.1 4.8 0.027 13.6 4.8 1.2 1 0 0 1 1 1 0 Ion transport protein Methyltransf_12 PF08242.10 001007623.1_45724001_2 - 1.6e-15 57.5 0.0 4.8e-15 55.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.4 001007623.1_45724001_2 - 1e-11 45.2 0.0 1.8e-11 44.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 001007623.1_45724001_2 - 3.6e-11 43.1 0.1 6.3e-11 42.3 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001007623.1_45724001_2 - 3.5e-08 33.8 0.0 6e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 001007623.1_45724001_2 - 5.6e-06 26.1 0.0 8.7e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.12 001007623.1_45724001_2 - 0.048 13.1 0.0 0.085 12.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain LRR_8 PF13855.4 001014053.1_45723001_2 - 1.4e-27 95.1 13.6 2.4e-15 55.9 0.1 4.3 3 1 2 5 5 5 3 Leucine rich repeat LRR_4 PF12799.5 001014053.1_45723001_2 - 1e-09 38.3 12.2 0.00034 20.8 0.4 4.5 4 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001014053.1_45723001_2 - 8.1e-05 22.1 0.2 0.0012 18.3 0.1 2.1 1 1 0 2 2 2 1 Leucine-rich repeat LRR_1 PF00560.31 001014053.1_45723001_2 - 0.018 15.3 12.0 0.69 10.5 0.1 6.3 7 1 0 7 7 7 0 Leucine Rich Repeat LRR_5 PF13306.4 001014053.1_45723001_2 - 0.11 12.3 0.0 2.5 7.9 0.0 2.2 2 0 0 2 2 2 0 Leucine rich repeats (6 copies) Fe_hyd_lg_C PF02906.12 001013183.1_45725001_1 - 2.1e-78 263.2 0.0 3.2e-78 262.6 0.0 1.3 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Fe_hyd_SSU PF02256.15 001013183.1_45725001_1 - 2.9e-08 33.5 0.2 7.6e-08 32.2 0.2 1.8 1 0 0 1 1 1 1 Iron hydrogenase small subunit NRho PF16733.3 001013183.1_45725001_1 - 0.087 12.8 0.2 0.4 10.6 0.0 2.2 2 0 0 2 2 2 0 Rhomboid N-terminal domain AP3D1 PF06375.9 001013183.1_45725001_1 - 1.3 9.2 12.1 2.1 8.5 12.1 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 NUDIX PF00293.26 053598.1_45726001_3 - 3.8e-18 65.6 0.7 6e-18 65.0 0.7 1.2 1 0 0 1 1 1 1 NUDIX domain Ldh_1_N PF00056.21 017266.2_45723001_2 - 6.6e-44 149.3 0.7 1e-43 148.6 0.7 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 017266.2_45723001_2 - 5.6e-26 91.3 0.0 9.1e-26 90.6 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain UDPG_MGDP_dh_N PF03721.12 017266.2_45723001_2 - 0.036 13.5 0.1 0.066 12.7 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ThiF PF00899.19 017266.2_45723001_2 - 0.061 12.5 0.1 0.11 11.7 0.1 1.3 1 0 0 1 1 1 0 ThiF family Glyco_hydro_4 PF02056.14 017266.2_45723001_2 - 0.13 11.6 0.5 1.8 7.9 0.1 2.2 2 0 0 2 2 2 0 Family 4 glycosyl hydrolase Glyco_hydro_38C PF07748.11 199404.1_45727001_2 - 5.3e-100 335.5 0.0 6.6e-100 335.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Glyco_hydro_38 PF01074.20 199404.1_45727001_2 - 3.4e-94 315.3 2.7 4.9e-94 314.8 2.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Alpha-mann_mid PF09261.9 199404.1_45727001_2 - 5.4e-20 71.4 0.0 1.4e-19 70.1 0.0 1.7 1 0 0 1 1 1 1 Alpha mannosidase middle domain TPR_1 PF00515.26 213625.1_45723001_1 - 7.8e-41 136.1 29.5 6.2e-07 28.8 0.1 8.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.15 213625.1_45723001_1 - 2.5e-39 130.1 22.6 5.1e-06 26.1 1.8 9.6 9 0 0 9 9 9 7 Tetratricopeptide repeat DnaJ PF00226.29 213625.1_45723001_1 - 4.9e-24 84.1 2.2 4.9e-24 84.1 2.2 2.8 3 0 0 3 3 2 1 DnaJ domain TPR_8 PF13181.4 213625.1_45723001_1 - 9.9e-24 81.4 19.0 0.00084 19.2 0.1 8.8 8 1 0 8 8 8 6 Tetratricopeptide repeat TPR_11 PF13414.4 213625.1_45723001_1 - 2.4e-18 65.4 22.2 6.1e-07 28.9 4.0 7.7 5 1 2 7 7 7 4 TPR repeat TPR_17 PF13431.4 213625.1_45723001_1 - 6.8e-17 60.5 11.2 7.5e-05 22.7 0.1 7.2 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_16 PF13432.4 213625.1_45723001_1 - 4.3e-16 59.2 4.6 0.0022 18.5 0.4 5.4 4 1 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.4 213625.1_45723001_1 - 1.3e-15 57.5 12.2 0.0061 16.9 0.1 6.4 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_12 PF13424.4 213625.1_45723001_1 - 9.9e-15 54.5 19.2 1.9e-05 24.7 1.1 6.8 5 3 1 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.4 213625.1_45723001_1 - 2.7e-11 43.1 10.4 0.58 11.0 0.0 8.4 7 2 3 10 10 8 2 Tetratricopeptide repeat TPR_9 PF13371.4 213625.1_45723001_1 - 9.8e-10 38.3 6.3 0.3 11.2 0.5 5.4 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.4 213625.1_45723001_1 - 2.8e-08 33.1 10.7 0.15 12.0 0.2 7.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.4 213625.1_45723001_1 - 9.4e-07 29.0 14.4 0.31 11.6 0.5 6.9 6 0 0 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.5 213625.1_45723001_1 - 9.9e-07 28.8 28.0 0.024 14.7 0.3 5.9 1 1 4 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.4 213625.1_45723001_1 - 8.2e-05 22.2 18.6 0.55 10.1 0.4 6.5 8 0 0 8 8 7 3 Tetratricopeptide repeat RPT PF13446.4 213625.1_45723001_1 - 0.045 13.5 0.2 0.21 11.4 0.0 2.3 2 0 0 2 2 1 0 A repeated domain in UCH-protein Rapsyn_N PF10579.7 213625.1_45723001_1 - 0.086 12.8 0.5 15 5.7 0.0 3.7 3 0 0 3 3 3 0 Rapsyn N-terminal myristoylation and linker region Sel1 PF08238.10 213625.1_45723001_1 - 0.17 12.5 4.9 2.9 8.5 0.4 4.0 3 0 0 3 3 3 0 Sel1 repeat RPN7 PF10602.7 213625.1_45723001_1 - 0.18 11.3 13.9 0.14 11.7 3.7 3.0 2 1 0 2 2 2 0 26S proteasome subunit RPN7 TPR_3 PF07720.10 213625.1_45723001_1 - 0.28 11.1 10.9 0.49 10.3 4.5 4.1 5 0 0 5 5 4 0 Tetratricopeptide repeat BTAD PF03704.15 213625.1_45723001_1 - 0.29 11.5 10.1 21 5.4 0.2 4.2 2 2 2 4 4 4 0 Bacterial transcriptional activator domain MIT PF04212.16 213625.1_45723001_1 - 0.34 10.9 23.8 0.38 10.7 1.3 5.9 4 2 1 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_4 PF07721.12 213625.1_45723001_1 - 0.48 11.1 1.8 36 5.3 0.2 3.4 3 0 0 3 3 2 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.4 213625.1_45723001_1 - 1.1 9.6 11.3 52 4.1 2.9 4.5 3 2 1 4 4 4 0 Alkyl sulfatase dimerisation SHNi-TPR PF10516.7 213625.1_45723001_1 - 1.2 8.5 8.3 4.2 6.8 0.1 5.1 6 1 1 7 7 7 0 SHNi-TPR zf-H2C2_2 PF13465.4 052798.2_45726001_1 - 5.2e-89 288.9 84.9 9.9e-09 35.1 0.4 14.7 15 0 0 15 15 15 13 Zinc-finger double domain zf-C2H2 PF00096.24 052798.2_45726001_1 - 3.5e-64 209.7 92.6 3.7e-05 23.8 2.0 13.6 13 0 0 13 13 13 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 052798.2_45726001_1 - 5.8e-42 138.6 86.0 0.0021 18.6 2.6 13.7 13 0 0 13 13 13 13 C2H2-type zinc finger zf-C2H2_6 PF13912.4 052798.2_45726001_1 - 4.7e-27 93.3 74.4 0.018 14.8 0.9 13.8 13 0 0 13 13 13 13 C2H2-type zinc finger KRAB PF01352.25 052798.2_45726001_1 - 1.3e-21 75.8 1.0 2.5e-21 74.9 1.0 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 052798.2_45726001_1 - 1.7e-13 50.3 52.5 0.008 16.3 2.4 13.4 13 0 0 13 13 13 3 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 052798.2_45726001_1 - 2.1e-12 46.8 56.8 0.032 14.2 1.2 9.9 7 3 3 10 10 10 7 Zinc ribbon domain zf-C2H2_11 PF16622.3 052798.2_45726001_1 - 2e-11 43.3 79.7 0.00014 21.4 0.2 13.0 13 0 0 13 13 13 6 zinc-finger C2H2-type C1_4 PF07975.10 052798.2_45726001_1 - 6.8e-05 22.9 53.8 0.016 15.3 0.6 9.1 3 3 8 11 11 11 5 TFIIH C1-like domain XPA_N PF01286.16 052798.2_45726001_1 - 0.00088 19.1 59.6 4.7 7.2 0.1 13.3 13 0 0 13 13 13 1 XPA protein N-terminal zinc_ribbon_15 PF17032.3 052798.2_45726001_1 - 0.0013 19.3 58.4 0.064 13.9 1.5 7.4 3 2 6 9 9 8 5 zinc-ribbon family DUF3656 PF12392.6 052798.2_45726001_1 - 0.14 12.7 1.2 18 5.9 0.6 4.3 4 2 1 5 5 5 0 Collagenase BolA PF01722.16 052798.2_45726001_1 - 0.18 11.9 13.8 0.8 9.9 0.5 4.9 3 2 0 4 4 4 0 BolA-like protein HypA PF01155.17 052798.2_45726001_1 - 0.33 10.8 48.9 1.6 8.6 0.9 7.2 1 1 3 4 4 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-met PF12874.5 052798.2_45726001_1 - 0.34 11.2 82.5 0.64 10.4 1.0 13.2 13 0 0 13 13 13 0 Zinc-finger of C2H2 type DUF3268 PF11672.6 052798.2_45726001_1 - 0.4 10.9 41.0 3.3 7.9 0.5 7.0 5 2 3 8 8 8 0 zinc-finger-containing domain Zn_Tnp_IS1595 PF12760.5 052798.2_45726001_1 - 5.8 6.8 72.4 0.36 10.7 2.2 9.2 6 2 2 9 9 9 0 Transposase zinc-ribbon domain PX PF00787.22 001024999.1_45723001_2 - 2e-14 53.4 0.3 4.3e-14 52.3 0.3 1.5 1 0 0 1 1 1 1 PX domain TPR_12 PF13424.4 001024999.1_45723001_2 - 0.017 15.3 1.2 0.13 12.4 0.1 2.7 1 1 1 2 2 2 0 Tetratricopeptide repeat Flp_N PF03930.12 001024999.1_45723001_2 - 0.057 13.3 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Recombinase Flp protein N-terminus I-set PF07679.14 017242.1_45723001_2 - 3.2e-45 152.0 4.9 1.1e-17 63.7 0.0 3.7 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 017242.1_45723001_2 - 5.2e-44 148.6 5.0 1e-18 67.6 0.9 3.3 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 017242.1_45723001_2 - 2.1e-31 108.0 3.6 2.4e-13 50.1 0.2 3.5 3 1 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 017242.1_45723001_2 - 1e-30 105.6 5.0 1.6e-13 50.5 0.2 4.4 4 1 0 4 4 4 4 Immunoglobulin domain V-set PF07686.15 017242.1_45723001_2 - 4e-18 65.4 5.6 7.9e-07 29.1 0.1 5.5 3 3 2 5 5 5 5 Immunoglobulin V-set domain Ig_5 PF16681.3 017242.1_45723001_2 - 2e-10 40.8 1.1 0.065 13.5 0.0 3.8 3 2 0 3 3 3 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 017242.1_45723001_2 - 1.4e-08 34.6 1.5 0.0056 16.6 0.1 4.0 4 0 0 4 4 4 3 Izumo-like Immunoglobulin domain C2-set_2 PF08205.10 017242.1_45723001_2 - 3e-06 27.1 1.7 0.094 12.7 0.0 3.4 4 0 0 4 4 3 2 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.3 017242.1_45723001_2 - 1.1e-05 25.6 5.0 0.16 12.2 0.0 4.4 3 2 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain C1-set PF07654.13 017242.1_45723001_2 - 7.3e-05 23.0 2.8 1 9.7 0.0 3.8 4 0 0 4 4 4 2 Immunoglobulin C1-set domain V-set_CD47 PF08204.9 017242.1_45723001_2 - 9.2e-05 22.3 2.7 0.14 12.0 0.3 3.1 2 1 1 3 3 3 2 CD47 immunoglobulin-like domain Adeno_E3_CR1 PF02440.13 017242.1_45723001_2 - 0.00018 21.1 5.6 0.94 9.2 0.1 4.6 3 2 0 3 3 3 2 Adenovirus E3 region protein CR1 C2-set PF05790.13 017242.1_45723001_2 - 0.05 13.6 1.4 22 5.2 0.0 4.3 6 0 0 6 6 6 0 Immunoglobulin C2-set domain ubiquitin PF00240.21 031129.3_45721001_2 - 2.4e-07 30.3 0.0 4e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 031129.3_45721001_2 - 0.0099 15.6 0.1 0.02 14.6 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like MCLC PF05934.9 133414.1_45728001_1 - 0 1145.3 0.0 0 1145.1 0.0 1.0 1 0 0 1 1 1 1 Mid-1-related chloride channel (MCLC) ADH_zinc_N PF00107.24 001012183.2_45724001_3 - 5.6e-27 94.1 0.6 2.2e-26 92.1 0.2 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.4 001012183.2_45724001_3 - 3.8e-18 66.7 0.0 5.9e-18 66.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 001012183.2_45724001_3 - 1.6e-11 43.9 0.0 3.2e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.23 001012183.2_45724001_3 - 0.064 12.6 0.3 0.1 11.9 0.3 1.3 1 0 0 1 1 1 0 short chain dehydrogenase DapB_N PF01113.18 001012183.2_45724001_3 - 1.2 9.1 3.3 0.46 10.5 0.6 1.7 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Phosphorylase PF00343.18 001024863.1_39528001_2 - 0 1146.1 0.0 0 1145.9 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase Ion_trans PF00520.29 139216.1_45727001_2 - 6.4e-44 149.9 14.2 9.4e-44 149.3 14.2 1.3 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 139216.1_45727001_2 - 7.9e-23 80.5 0.0 1.7e-21 76.2 0.0 2.4 1 1 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 139216.1_45727001_2 - 1e-10 41.3 2.8 1e-10 41.3 2.8 2.5 2 0 0 2 2 2 1 Ion channel BTB_3 PF16017.3 139216.1_45727001_2 - 0.07 13.1 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 BTB/POZ domain Lipocalin PF00061.21 013068.1_45722001_1 - 1.1e-15 58.0 3.3 1.2e-15 57.8 3.3 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 013068.1_45722001_1 - 5.5e-08 32.7 2.7 6.8e-08 32.4 2.7 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_4 PF13648.4 013068.1_45722001_1 - 0.0026 18.5 2.7 0.007 17.2 2.7 1.7 1 1 0 1 1 1 1 Lipocalin-like domain AA_permease_2 PF13520.4 031341.1_45725001_1 - 2.4e-60 204.4 40.1 3.1e-60 204.1 40.1 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.19 031341.1_45725001_1 - 7.4e-26 90.6 33.0 1e-25 90.2 33.0 1.2 1 0 0 1 1 1 1 Amino acid permease Pkinase_Tyr PF07714.15 031794.1_45726001_1 - 9.3e-90 300.3 0.0 1.2e-89 299.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 031794.1_45726001_1 - 6.5e-37 127.2 0.0 8.8e-37 126.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.19 031794.1_45726001_1 - 1.3e-20 73.3 0.5 2.2e-10 40.6 0.0 2.7 2 0 0 2 2 2 2 Fibronectin type III domain Ig_3 PF13927.4 031794.1_45726001_1 - 1.1e-16 61.1 0.3 6.2e-08 33.0 0.0 3.7 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.4 031794.1_45726001_1 - 3.1e-13 49.7 0.0 6.3e-06 26.3 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 031794.1_45726001_1 - 1.3e-11 44.4 0.0 7e-07 29.2 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 031794.1_45726001_1 - 9.6e-10 38.3 0.0 1e-05 25.4 0.0 2.9 2 1 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.15 031794.1_45726001_1 - 3.9e-05 23.6 0.0 0.00014 21.8 0.0 2.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain C1-set PF07654.13 031794.1_45726001_1 - 0.0014 18.9 0.0 0.019 15.3 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin C1-set domain DUF4381 PF14316.4 031794.1_45726001_1 - 0.0068 16.5 0.0 0.014 15.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) C2-set_2 PF08205.10 031794.1_45726001_1 - 0.008 16.1 0.2 1.5 8.8 0.0 2.6 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain TPP_enzyme_N PF02776.16 053493.1_45725001_3 - 3.9e-46 156.6 0.2 5.7e-44 149.6 0.2 2.7 2 1 0 2 2 2 2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.20 053493.1_45725001_3 - 2.4e-33 114.7 0.0 6.7e-33 113.2 0.0 1.7 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.19 053493.1_45725001_3 - 9.2e-27 93.6 0.0 2.8e-26 92.0 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain CO_dh PF02552.14 053493.1_45725001_3 - 0.0079 15.8 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit NMT1_3 PF16868.3 053493.1_45725001_3 - 0.083 12.2 0.1 0.13 11.5 0.1 1.2 1 0 0 1 1 1 0 NMT1-like family LLGL PF08366.11 178345.1_45727001_1 - 8.7e-34 115.9 0.0 2.2e-33 114.6 0.0 1.7 1 0 0 1 1 1 1 LLGL2 ANAPC4_WD40 PF12894.5 178345.1_45727001_1 - 1.2e-11 44.6 0.7 0.045 13.9 0.0 6.9 3 2 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 178345.1_45727001_1 - 3.8e-08 33.7 9.7 0.019 15.7 0.3 6.5 7 1 0 7 7 7 2 WD domain, G-beta repeat Lgl_C PF08596.8 178345.1_45727001_1 - 2.3e-06 26.5 0.0 4.5e-05 22.2 0.0 3.0 4 0 0 4 4 4 1 Lethal giant larvae(Lgl) like, C-terminal Synaptobrevin PF00957.19 178345.1_45727001_1 - 0.00014 21.5 0.1 0.00037 20.1 0.1 1.7 1 0 0 1 1 1 1 Synaptobrevin Frtz PF11768.6 178345.1_45727001_1 - 0.0019 16.4 0.0 0.016 13.4 0.0 2.4 3 0 0 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.3 178345.1_45727001_1 - 0.0099 15.1 0.0 0.043 13.0 0.0 2.1 2 1 0 2 2 2 1 WD40-like domain RAB3GAP2_N PF14655.4 178345.1_45727001_1 - 0.019 14.1 0.1 1.4 7.9 0.1 3.2 3 1 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus ELYS-bb PF16687.3 178345.1_45727001_1 - 0.037 12.5 0.0 12 4.3 0.0 3.1 2 1 1 3 3 3 0 beta-propeller of ELYS nucleoporin Hira PF07569.9 178345.1_45727001_1 - 0.057 13.0 0.0 4.7 6.7 0.0 3.7 2 1 2 4 4 4 0 TUP1-like enhancer of split RHD_DNA_bind PF00554.20 001008349.1_45727001_1 - 3.2e-65 219.1 0.0 4.5e-65 218.6 0.0 1.2 1 0 0 1 1 1 1 Rel homology DNA-binding domain RHD_dimer PF16179.3 001008349.1_45727001_1 - 3.9e-39 132.7 0.0 7.1e-39 131.9 0.0 1.4 1 0 0 1 1 1 1 Rel homology dimerisation domain Ank_2 PF12796.5 001008349.1_45727001_1 - 3.3e-29 101.2 11.6 7.8e-11 42.3 0.3 4.0 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001008349.1_45727001_1 - 5.6e-23 80.5 7.1 2e-06 27.8 0.2 5.4 5 0 0 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.28 001008349.1_45727001_1 - 1.6e-22 78.7 19.3 3.5e-05 23.9 0.0 6.8 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.4 001008349.1_45727001_1 - 6.5e-20 69.0 6.9 0.00016 21.7 0.1 6.7 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.4 001008349.1_45727001_1 - 7.5e-16 58.2 2.6 0.00033 21.0 0.0 5.0 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Death PF00531.20 001008349.1_45727001_1 - 5.2e-07 29.6 0.0 9.4e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 Death domain DUF2384 PF09722.8 001008349.1_45727001_1 - 0.12 12.3 0.9 34 4.4 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2384) Tom5 PF10642.7 001008349.1_45727001_1 - 2.5 8.0 4.1 28 4.7 1.5 2.5 2 0 0 2 2 2 0 Mitochondrial import receptor subunit or translocase Fzo_mitofusin PF04799.11 138976.1_45725001_1 - 4.5e-75 250.4 8.7 4.5e-75 250.4 8.7 2.5 2 0 0 2 2 2 1 fzo-like conserved region Dynamin_N PF00350.21 138976.1_45725001_1 - 3.1e-23 82.6 5.4 9.3e-23 81.0 0.0 3.3 3 1 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.21 138976.1_45725001_1 - 6.6e-08 32.5 0.0 7.1e-07 29.2 0.0 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_23 PF13476.4 138976.1_45725001_1 - 0.91 9.9 13.3 7.2 6.9 0.0 3.4 3 0 0 3 3 3 0 AAA domain Cep57_MT_bd PF06657.11 138976.1_45725001_1 - 1.7 9.0 7.8 16 5.9 3.7 3.3 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 DUF5082 PF16888.3 138976.1_45725001_1 - 1.7 8.9 8.0 0.32 11.2 1.6 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) Paralemmin PF03285.13 138976.1_45725001_1 - 2 7.8 11.4 0.017 14.6 2.8 1.8 2 0 0 2 2 2 0 Paralemmin Synaptobrevin PF00957.19 138976.1_45725001_1 - 3 7.6 11.1 0.05 13.3 2.3 2.5 2 1 1 3 3 3 0 Synaptobrevin Exonuc_VII_L PF02601.13 138976.1_45725001_1 - 3.1 7.1 10.9 0.57 9.6 0.5 2.7 2 1 0 2 2 2 0 Exonuclease VII, large subunit CLZ PF16526.3 138976.1_45725001_1 - 4.1 7.7 10.6 1.9 8.7 0.2 3.7 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels MYO10_CC PF16735.3 138976.1_45725001_1 - 8.2 6.5 9.7 22 5.1 5.9 3.1 2 1 1 3 3 3 0 Unconventional myosin-X coiled coil domain LIM PF00412.20 053326.1_45724001_2 - 2.7e-39 133.1 27.3 8.6e-15 54.6 2.2 3.4 3 0 0 3 3 3 3 LIM domain PDZ PF00595.22 053326.1_45724001_2 - 4e-13 49.4 0.0 7.9e-13 48.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) DUF4749 PF15936.3 053326.1_45724001_2 - 1.7e-07 32.2 0.4 5e-07 30.7 0.4 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) PDZ_2 PF13180.4 053326.1_45724001_2 - 0.0058 16.8 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 PDZ domain FAA_hydrolase_N PF09298.9 053326.1_45724001_2 - 0.091 12.9 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal Sugar_tr PF00083.22 214455.1_49824001_1 - 3.4e-34 118.3 10.4 4.7e-34 117.9 10.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 214455.1_49824001_1 - 5.6e-28 97.8 23.8 7.7e-28 97.3 23.2 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.11 214455.1_49824001_1 - 0.04 12.2 3.3 0.063 11.5 3.3 1.2 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) Glyco_hydro_31 PF01055.24 013061.1_45729001_3 - 7.6e-271 898.5 19.2 1.1e-141 472.9 7.6 2.1 2 0 0 2 2 2 2 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.3 013061.1_45729001_3 - 1.2e-64 215.6 0.1 3e-33 114.3 0.1 2.5 2 0 0 2 2 2 2 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Trefoil PF00088.16 013061.1_45729001_3 - 2.4e-14 52.8 14.7 8.1e-09 35.1 3.1 2.7 3 0 0 3 3 3 2 Trefoil (P-type) domain DUF5110 PF17137.2 013061.1_45729001_3 - 7.1e-10 38.9 1.0 0.00027 21.0 0.2 3.1 3 0 0 3 3 3 2 Domain of unknown function (DUF5110) Gal_mutarotas_2 PF13802.4 013061.1_45729001_3 - 1.8e-09 37.6 10.0 0.00015 21.9 1.6 3.0 2 0 0 2 2 2 2 Galactose mutarotase-like Glyco_transf_29 PF00777.16 001009037.1_39723001_1 - 1.7e-79 266.9 0.0 2.1e-79 266.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) IL2 PF00715.15 213861.1_49822001_1 - 2.1e-76 254.6 5.9 2.6e-76 254.4 5.9 1.1 1 0 0 1 1 1 1 Interleukin 2 Gal-bind_lectin PF00337.20 001009287.1_39521001_3 - 4.1e-29 100.7 0.0 5e-29 100.4 0.0 1.0 1 0 0 1 1 1 1 Galactoside-binding lectin DUF1344 PF07076.9 001009287.1_39521001_3 - 0.021 14.6 0.0 0.074 12.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1344) DNA_ligase_aden PF01653.16 001009287.1_39521001_3 - 0.18 10.7 0.0 0.24 10.3 0.0 1.1 1 0 0 1 1 1 0 NAD-dependent DNA ligase adenylation domain AMP-binding PF00501.26 031736.1_45726001_3 - 4.1e-67 226.5 0.0 5e-67 226.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 031736.1_45726001_3 - 1.2e-06 29.3 0.0 4e-06 27.6 0.0 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain P33MONOX PF15302.4 001014007.1_45725001_1 - 1.5e-129 431.7 7.8 1.9e-129 431.4 7.8 1.1 1 0 0 1 1 1 1 P33 mono-oxygenase Cadherin PF00028.15 053940.1_45729001_1 - 4.5e-78 257.7 0.1 2.6e-20 72.5 0.0 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 053940.1_45729001_1 - 9.7e-63 210.3 4.7 1.6e-62 209.6 4.7 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 053940.1_45729001_1 - 5.1e-32 109.4 5.7 1.1e-28 98.8 0.1 4.5 5 0 0 5 5 5 2 Cadherin-like Cadherin_3 PF16184.3 053940.1_45729001_1 - 5e-06 26.4 4.2 0.68 9.8 0.1 4.5 4 0 0 4 4 4 3 Cadherin-like Cadherin_C_2 PF16492.3 053940.1_45729001_1 - 5.9e-05 23.6 0.0 0.00019 22.0 0.0 1.9 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal DUF4958 PF16319.3 053940.1_45729001_1 - 0.011 13.7 0.0 0.019 12.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4958) PH PF00169.27 001025115.1_45723001_1 - 2.7e-07 30.9 0.6 8e-07 29.4 0.2 2.0 2 0 0 2 2 2 1 PH domain SH2 PF00017.22 001025115.1_45723001_1 - 0.0013 18.6 0.0 0.0028 17.6 0.0 1.5 1 0 0 1 1 1 1 SH2 domain DUF4174 PF13778.4 001025115.1_45723001_1 - 0.03 14.7 0.0 0.056 13.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) PH_11 PF15413.4 001025115.1_45723001_1 - 0.034 14.4 1.2 0.25 11.7 1.2 2.2 1 1 0 1 1 1 0 Pleckstrin homology domain SR-25 PF10500.7 001009685.1_45724001_1 - 0.11 12.0 30.9 0.18 11.3 30.9 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MMR_HSR1_Xtn PF16897.3 001009685.1_45724001_2 - 3.8e-45 152.2 0.3 6.2e-45 151.5 0.3 1.3 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.19 001009685.1_45724001_2 - 8.7e-25 86.4 0.0 1.7e-24 85.5 0.0 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.21 001009685.1_45724001_2 - 4.3e-19 68.5 0.0 4.3e-19 68.5 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.16 001009685.1_45724001_2 - 2.8e-10 39.8 0.1 2.2e-09 36.9 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B ArgK PF03308.14 001009685.1_45724001_2 - 0.037 12.9 0.0 0.037 12.9 0.0 2.2 3 0 0 3 3 3 0 ArgK protein Connexin PF00029.17 001009685.1_45724001_2 - 1.7 8.2 5.4 2.6 7.6 5.4 1.2 1 0 0 1 1 1 0 Connexin GTP_EFTU PF00009.25 001009685.1_45724001_2 - 3.8 6.9 7.3 7.1 6.0 0.0 3.7 3 2 1 4 4 4 0 Elongation factor Tu GTP binding domain Dynamin_N PF00350.21 001009685.1_45724001_2 - 7.8 6.4 12.1 4.1 7.3 0.2 3.1 2 1 1 3 3 3 0 Dynamin family DUF4770 PF15994.3 001009685.1_45724001_3 - 0.43 10.7 10.3 0.62 10.1 10.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) HIN PF02760.13 001012029.1_45724001_3 - 9.5e-68 227.0 2.8 1.6e-67 226.2 2.8 1.4 1 0 0 1 1 1 1 HIN-200/IF120x domain PYRIN PF02758.14 001012029.1_45724001_3 - 8.1e-09 35.4 1.0 2.9e-08 33.7 0.2 2.2 2 0 0 2 2 2 1 PAAD/DAPIN/Pyrin domain Ribosomal_L28e PF01778.15 022697.2_45724001_1 - 6.8e-35 120.1 1.8 1.1e-34 119.4 1.8 1.3 1 0 0 1 1 1 1 Ribosomal L28e protein family Glyco_hydro_59 PF02057.13 001005888.1_45725001_2 - 0 1353.5 10.0 0 1353.3 10.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 Glyco_hydro_30 PF02055.14 001005888.1_45725001_2 - 0.059 12.2 0.3 0.11 11.3 0.0 1.5 2 0 0 2 2 2 0 Glycosyl hydrolase family 30 TIM-barrel domain RRM_1 PF00076.20 001014127.1_45723001_2 - 1.8e-17 62.8 0.0 3.1e-17 62.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ELO PF01151.16 134382.1_45722001_1 - 3.4e-66 223.2 23.9 4.2e-66 222.9 23.9 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family MFS_1 PF07690.14 001047910.1_45724001_2 - 1.4e-23 83.2 34.8 1.1e-16 60.6 17.0 2.7 2 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 001047910.1_45724001_2 - 2.4e-11 43.0 0.4 2.4e-11 43.0 0.4 2.7 3 0 0 3 3 3 2 Sugar (and other) transporter Trypsin PF00089.24 019175.1_45723001_2 - 2.2e-73 246.6 0.5 2.7e-73 246.3 0.5 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 019175.1_45723001_2 - 9.6e-09 35.5 0.0 1.9e-08 34.5 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 019175.1_45723001_2 - 2.3e-06 28.4 0.0 3.5e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain Hydrolase_4 PF12146.6 181533.3_26224001_2 - 4.7e-21 75.0 0.0 1.8e-16 60.0 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.18 181533.3_26224001_2 - 1.7e-14 53.9 0.0 1.8e-12 47.3 0.0 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 181533.3_26224001_2 - 4.5e-12 46.9 0.4 8.9e-11 42.7 0.0 2.4 2 1 1 3 3 3 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.19 181533.3_26224001_2 - 2.1e-05 24.0 0.0 5.3e-05 22.6 0.0 1.6 1 1 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.16 181533.3_26224001_2 - 0.00035 20.1 0.0 0.00055 19.5 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Thioesterase PF00975.18 181533.3_26224001_2 - 0.0043 17.1 0.0 0.0094 16.0 0.0 1.4 1 1 0 1 1 1 1 Thioesterase domain Abhydrolase_3 PF07859.11 181533.3_26224001_2 - 0.0054 16.5 0.0 0.0096 15.6 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold LIP PF03583.12 181533.3_26224001_2 - 0.006 15.8 0.0 0.037 13.2 0.0 1.8 2 0 0 2 2 2 1 Secretory lipase Abhydrolase_2 PF02230.14 181533.3_26224001_2 - 0.055 13.1 0.0 0.12 12.0 0.0 1.5 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase PGAP1 PF07819.11 181533.3_26224001_2 - 0.11 12.1 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein HMA PF00403.24 001009732.1_39529001_2 - 6.1e-83 273.1 0.5 2.4e-12 47.0 0.0 6.5 6 0 0 6 6 6 6 Heavy-metal-associated domain Hydrolase PF00702.24 001009732.1_39529001_2 - 3.8e-64 216.7 0.7 6.2e-64 216.0 0.7 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.18 001009732.1_39529001_2 - 2.3e-59 200.2 3.8 5.9e-59 198.9 3.8 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.10 001009732.1_39529001_2 - 1.4e-06 28.2 2.3 5.6e-05 22.9 0.5 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.4 001009732.1_39529001_2 - 0.0072 16.3 0.4 0.023 14.6 0.2 2.1 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase HAD PF12710.5 001009732.1_39529001_2 - 0.016 15.5 0.0 0.029 14.6 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase HAD_2 PF13419.4 001009732.1_39529001_2 - 0.03 14.3 0.1 0.058 13.3 0.1 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Fer2_BFD PF04324.13 001009732.1_39529001_2 - 5.2 7.4 13.9 49 4.3 0.2 6.2 6 0 0 6 6 6 0 BFD-like [2Fe-2S] binding domain Galactosyl_T PF01762.19 001009096.1_39722001_1 - 9.4e-61 204.9 0.0 1.2e-60 204.6 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Insulin PF00049.16 213872.1_49822001_1 - 4.1e-20 72.4 2.0 1.1e-19 71.1 2.0 1.7 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family Ins_beta PF03488.12 213872.1_49822001_1 - 0.0072 16.2 4.9 1 9.3 0.1 2.3 2 0 0 2 2 2 2 Nematode insulin-related peptide beta type GTP1_OBG PF01018.20 001013924.1_45724001_1 - 1e-44 151.7 4.5 1.4e-44 151.3 4.5 1.2 1 0 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.21 001013924.1_45724001_1 - 6.4e-24 84.1 0.0 1e-23 83.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 001013924.1_45724001_1 - 1.8e-11 43.7 0.0 1.8e-10 40.4 0.0 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.19 001013924.1_45724001_1 - 0.0071 15.7 0.0 0.015 14.6 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family Dynamin_N PF00350.21 001013924.1_45724001_1 - 0.0078 16.2 0.0 1.3 8.9 0.0 2.2 1 1 1 2 2 2 2 Dynamin family DUF258 PF03193.14 001013924.1_45724001_1 - 0.065 13.0 0.0 1.7 8.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Ras PF00071.20 001013924.1_45724001_1 - 0.19 11.2 0.0 0.36 10.3 0.0 1.5 1 1 0 1 1 1 0 Ras family ABC_membrane_2 PF06472.13 012804.1_45727001_3 - 2.6e-102 341.8 6.9 3.5e-102 341.4 6.9 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.25 012804.1_45727001_3 - 1.6e-17 64.2 0.0 2.8e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.4 012804.1_45727001_3 - 0.0023 18.4 0.0 0.0041 17.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.17 012804.1_45727001_3 - 0.0057 16.0 0.0 0.52 9.6 0.0 2.3 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.4 012804.1_45727001_3 - 0.025 14.2 0.0 0.045 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 012804.1_45727001_3 - 0.031 13.9 0.0 0.061 12.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain PNK3P PF08645.9 001004259.1_45724001_3 - 2.1e-53 180.2 0.0 3e-53 179.6 0.0 1.2 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.4 001004259.1_45724001_3 - 5.2e-19 68.7 0.7 3.3e-16 59.6 0.7 2.4 1 1 0 1 1 1 1 AAA domain HAD PF12710.5 001004259.1_45724001_3 - 0.00031 21.1 0.3 0.62 10.3 0.0 2.8 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase Zeta_toxin PF06414.10 001004259.1_45724001_3 - 0.00063 19.0 0.0 0.0053 16.0 0.0 2.2 1 1 1 2 2 2 1 Zeta toxin Hydrolase_6 PF13344.4 001004259.1_45724001_3 - 0.001 19.0 0.0 0.0048 16.9 0.0 2.1 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.24 001004259.1_45724001_3 - 0.0054 16.9 0.7 2.3 8.3 0.0 2.5 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.4 001004259.1_45724001_3 - 0.025 14.5 0.0 1.9 8.4 0.0 2.5 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase AAA_17 PF13207.4 001004259.1_45724001_3 - 0.067 13.5 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.16 001004259.1_45724001_3 - 0.073 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase FHA PF00498.24 001004259.1_45724001_3 - 0.095 12.9 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 FHA domain Peptidase_C69 PF03577.13 001012142.1_45723001_3 - 2.2e-06 27.0 0.0 3.1e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C69 AAT PF03417.14 001012142.1_45723001_3 - 0.015 14.9 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase E_Pc_C PF06752.10 001012142.1_45723001_3 - 2.3 8.1 4.3 4.1 7.3 4.3 1.3 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus FGF PF00167.16 012846.1_45723001_3 - 8.5e-42 142.1 0.0 1.2e-41 141.6 0.0 1.2 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.11 012846.1_45723001_3 - 0.011 15.8 0.0 0.025 14.7 0.0 1.6 1 0 0 1 1 1 0 Fascin domain FMO-like PF00743.17 001009092.1_39724001_1 - 1.6e-300 996.9 0.0 1.8e-300 996.7 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.4 001009092.1_39724001_1 - 6.4e-16 58.3 0.0 9.3e-12 44.7 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.12 001009092.1_39724001_1 - 5e-11 42.3 0.0 4.3e-10 39.2 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.4 001009092.1_39724001_1 - 2.5e-09 36.6 0.1 2e-07 30.4 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.4 001009092.1_39724001_1 - 4.9e-06 26.6 0.1 2.3e-05 24.4 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.25 001009092.1_39724001_1 - 3.9e-05 24.0 0.0 0.019 15.4 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 001009092.1_39724001_1 - 7.5e-05 22.4 0.0 0.14 11.6 0.0 3.6 4 0 0 4 4 4 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.4 001009092.1_39724001_1 - 0.0029 17.5 0.0 0.99 9.3 0.0 3.3 2 1 1 3 3 3 1 FAD-NAD(P)-binding IlvN PF07991.10 001009092.1_39724001_1 - 0.0078 15.7 0.0 1.3 8.4 0.0 2.7 3 0 0 3 3 3 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.18 001009092.1_39724001_1 - 0.012 15.6 0.1 0.16 11.9 0.0 2.2 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.4 001009092.1_39724001_1 - 0.021 15.1 0.0 3.1 8.1 0.0 2.5 2 1 0 2 2 2 0 Putative NAD(P)-binding Thi4 PF01946.15 001009092.1_39724001_1 - 0.093 11.8 0.1 2.1 7.4 0.1 2.2 2 0 0 2 2 2 0 Thi4 family AlaDh_PNT_C PF01262.19 001009092.1_39724001_1 - 0.093 11.9 0.0 0.4 9.8 0.0 1.9 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.17 001009092.1_39724001_1 - 0.29 10.2 0.3 20 4.1 0.1 2.3 2 0 0 2 2 2 0 FAD binding domain FYVE_2 PF02318.14 133591.2_45725001_2 - 6.7e-37 126.2 3.5 1.4e-36 125.1 3.5 1.6 1 0 0 1 1 1 1 FYVE-type zinc finger zf-piccolo PF05715.11 133591.2_45725001_2 - 3.3e-05 23.8 7.5 7e-05 22.8 7.5 1.6 1 0 0 1 1 1 1 Piccolo Zn-finger zf-B_box PF00643.22 133591.2_45725001_2 - 0.088 12.8 3.6 0.094 12.8 1.1 2.3 2 0 0 2 2 2 0 B-box zinc finger 7TM_GPCR_Srx PF10328.7 133591.2_45725001_2 - 7.4 5.7 7.5 10 5.2 7.5 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx AMP-binding PF00501.26 130739.1_45726001_2 - 4.6e-109 364.7 0.0 6.7e-109 364.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 130739.1_45726001_2 - 0.00013 22.8 0.0 0.00033 21.4 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain RhoGAP-FF1 PF16512.3 001047869.1_45728001_1 - 1.8e-28 98.9 14.8 2.8e-28 98.3 5.9 3.7 4 0 0 4 4 4 1 p190-A and -B Rho GAPs FF domain Ras PF00071.20 001047869.1_45728001_1 - 1.8e-14 53.5 3.2 4.6e-05 22.9 0.3 4.5 4 0 0 4 4 4 4 Ras family FF PF01846.17 001047869.1_45728001_1 - 8e-14 51.4 9.4 1.2e-09 38.0 1.2 3.7 3 0 0 3 3 3 3 FF domain GTP_EFTU PF00009.25 001047869.1_45728001_1 - 0.0056 16.1 0.2 0.02 14.3 0.2 1.9 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain NOG1 PF06858.12 001047869.1_45728001_1 - 0.0086 15.7 0.1 0.025 14.2 0.1 1.8 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) Roc PF08477.11 001047869.1_45728001_1 - 0.012 15.7 0.0 0.54 10.4 0.0 3.1 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase U5_2-snRNA_bdg PF10597.7 001047869.1_45728001_1 - 0.026 14.5 0.3 0.097 12.7 0.1 2.0 2 0 0 2 2 2 0 U5-snRNA binding site 2 of PrP8 MMR_HSR1 PF01926.21 001047869.1_45728001_1 - 0.092 12.7 0.0 0.71 9.8 0.0 2.6 2 1 0 2 2 2 0 50S ribosome-binding GTPase C2 PF00168.28 053325.1_45723001_1 - 4.1e-32 110.4 0.0 5e-18 65.2 0.0 2.3 2 0 0 2 2 2 2 C2 domain UPF0560 PF10577.7 053325.1_45723001_1 - 0.0086 14.5 0.2 0.012 14.1 0.2 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0560 Adeno_E3_CR2 PF02439.13 053325.1_45723001_1 - 0.011 15.3 2.4 0.02 14.5 2.4 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 EphA2_TM PF14575.4 053325.1_45723001_1 - 0.016 15.9 0.0 0.042 14.5 0.0 1.8 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain SCIMP PF15050.4 053325.1_45723001_1 - 0.028 14.8 0.1 0.058 13.7 0.1 1.4 1 0 0 1 1 1 0 SCIMP protein TMEM100 PF16311.3 053325.1_45723001_1 - 0.074 12.5 0.3 0.14 11.6 0.3 1.4 1 0 0 1 1 1 0 Transmembrane protein 100 LRR_8 PF13855.4 182816.2_45727001_1 - 1e-31 108.4 22.1 8.6e-15 54.1 3.0 3.9 2 1 3 5 5 5 4 Leucine rich repeat LRR_4 PF12799.5 182816.2_45727001_1 - 1.7e-16 59.9 7.5 1.9e-06 27.9 0.1 4.5 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) ig PF00047.23 182816.2_45727001_1 - 2.3e-06 27.5 0.0 6.6e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain LRR_5 PF13306.4 182816.2_45727001_1 - 6e-06 26.1 0.2 1.1e-05 25.3 0.2 1.4 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) Ig_3 PF13927.4 182816.2_45727001_1 - 2.5e-05 24.7 0.0 6.6e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.31 182816.2_45727001_1 - 0.00015 21.7 7.4 12 6.7 0.1 6.7 5 1 1 6 6 6 1 Leucine Rich Repeat LRR_9 PF14580.4 182816.2_45727001_1 - 0.00031 20.1 0.6 0.0016 17.8 0.6 1.8 1 1 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.4 182816.2_45727001_1 - 0.00039 20.1 10.3 5 7.3 0.2 5.6 5 0 0 5 5 5 1 Leucine Rich repeat Ig_2 PF13895.4 182816.2_45727001_1 - 0.00093 19.4 0.0 0.0065 16.7 0.0 2.4 3 0 0 3 3 2 1 Immunoglobulin domain I-set PF07679.14 182816.2_45727001_1 - 0.0017 18.3 0.0 0.0036 17.2 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.15 182816.2_45727001_1 - 0.13 12.3 0.0 0.54 10.3 0.0 2.1 1 1 0 1 1 1 0 Immunoglobulin V-set domain Homeobox PF00046.27 133621.2_45723001_3 - 2.4e-09 36.7 0.1 4.2e-09 36.0 0.1 1.4 1 0 0 1 1 1 1 Homeobox domain DUF2205 PF10224.7 001013235.1_45724001_2 - 1.6e-26 91.9 3.6 2.5e-26 91.3 3.6 1.3 1 0 0 1 1 1 1 Predicted coiled-coil protein (DUF2205) IncA PF04156.12 001013235.1_45724001_2 - 0.029 14.0 2.0 0.042 13.5 2.0 1.2 1 0 0 1 1 1 0 IncA protein HALZ PF02183.16 001013235.1_45724001_2 - 0.13 12.4 7.3 0.56 10.3 2.3 2.7 1 1 1 2 2 2 0 Homeobox associated leucine zipper DUF972 PF06156.11 001013235.1_45724001_2 - 0.14 12.7 3.4 0.23 12.0 3.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF972) CENP-H PF05837.10 001013235.1_45724001_2 - 0.19 12.0 2.8 0.3 11.4 2.8 1.2 1 0 0 1 1 1 0 Centromere protein H (CENP-H) ZapB PF06005.10 001013235.1_45724001_2 - 0.78 10.1 6.4 1.4 9.3 6.4 1.3 1 0 0 1 1 1 0 Cell division protein ZapB Serum_albumin PF00273.18 214317.1_49825001_1 - 1.4e-150 497.1 30.8 4.1e-51 173.1 5.9 3.1 3 0 0 3 3 3 3 Serum albumin family VitD-bind_III PF09164.8 214317.1_49825001_1 - 0.01 15.7 18.0 0.23 11.3 0.2 4.8 5 0 0 5 5 5 0 Vitamin D binding protein, domain III DUF4144 PF13642.4 214317.1_49825001_1 - 0.031 14.7 3.6 7.2 7.1 0.3 3.5 3 0 0 3 3 3 0 protein structure with unknown function Topoisom_I PF01028.18 214317.1_49825001_1 - 0.052 12.6 0.3 0.093 11.8 0.3 1.3 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, catalytic core AAA PF00004.27 213983.1_49823001_2 - 6.1e-43 146.3 0.0 1.4e-42 145.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.12 213983.1_49823001_2 - 2.5e-07 30.8 0.0 6.2e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.12 213983.1_49823001_2 - 3.4e-06 27.0 0.0 1.7e-05 24.7 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.4 213983.1_49823001_2 - 4.8e-06 26.9 0.2 8.2e-05 22.9 0.0 2.6 3 1 0 4 4 2 1 AAA ATPase domain AAA_22 PF13401.4 213983.1_49823001_2 - 2.7e-05 24.3 1.4 0.0059 16.8 0.2 2.9 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.10 213983.1_49823001_2 - 0.00011 21.5 0.0 0.0002 20.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus TIP49 PF06068.11 213983.1_49823001_2 - 0.0017 17.2 0.0 0.0035 16.2 0.0 1.5 1 0 0 1 1 1 1 TIP49 C-terminus IstB_IS21 PF01695.15 213983.1_49823001_2 - 0.0019 17.9 0.0 0.0041 16.8 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.4 213983.1_49823001_2 - 0.002 18.2 0.0 0.0041 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 213983.1_49823001_2 - 0.0029 18.0 0.2 0.022 15.2 0.0 2.5 3 0 0 3 3 3 1 AAA domain Mg_chelatase PF01078.19 213983.1_49823001_2 - 0.0069 15.6 0.1 0.017 14.3 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.9 213983.1_49823001_2 - 0.007 16.1 0.0 0.019 14.7 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PhoH PF02562.14 213983.1_49823001_2 - 0.0084 15.5 0.1 0.14 11.4 0.0 2.5 3 0 0 3 3 3 1 PhoH-like protein ATPase PF06745.11 213983.1_49823001_2 - 0.0091 15.2 0.0 0.026 13.7 0.0 1.7 1 0 0 1 1 1 1 KaiC AAA_28 PF13521.4 213983.1_49823001_2 - 0.021 14.9 0.0 0.043 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain RILP PF11461.6 213983.1_49823001_2 - 0.025 14.7 3.4 0.056 13.5 3.4 1.6 1 0 0 1 1 1 0 Rab interacting lysosomal protein Sigma54_activat PF00158.24 213983.1_49823001_2 - 0.026 14.1 0.1 0.11 12.1 0.0 2.1 2 1 0 2 2 1 0 Sigma-54 interaction domain AAA_24 PF13479.4 213983.1_49823001_2 - 0.03 13.9 0.0 0.082 12.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain TsaE PF02367.15 213983.1_49823001_2 - 0.048 13.5 0.0 0.087 12.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.15 213983.1_49823001_2 - 0.052 12.5 0.0 0.088 11.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_14 PF13173.4 213983.1_49823001_2 - 0.055 13.4 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.4 213983.1_49823001_2 - 0.057 12.9 0.0 0.18 11.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.11 213983.1_49823001_2 - 0.058 12.4 0.0 0.12 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RNA_helicase PF00910.20 213983.1_49823001_2 - 0.07 13.4 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_11 PF13086.4 213983.1_49823001_2 - 0.075 12.6 0.4 0.44 10.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.4 213983.1_49823001_2 - 0.098 13.0 0.6 0.52 10.6 0.0 2.4 3 0 0 3 3 2 0 AAA domain AAA_19 PF13245.4 213983.1_49823001_2 - 0.12 12.5 0.0 0.37 11.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain Laminin_II PF06009.10 213983.1_49823001_2 - 0.24 11.3 3.5 1.3 8.8 0.9 2.7 3 0 0 3 3 3 0 Laminin Domain II MscS_porin PF12795.5 213983.1_49823001_2 - 4.4 6.6 11.6 6.9 6.0 11.6 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain Fip1 PF05182.11 001008295.1_45724001_2 - 5.2e-25 86.5 2.1 5.2e-25 86.5 2.1 1.9 2 0 0 2 2 2 1 Fip1 motif EGF PF00008.25 021689.1_45722001_1 - 0.004 17.3 3.5 0.012 15.8 3.5 1.9 1 0 0 1 1 1 1 EGF-like domain Sec66 PF09802.7 021689.1_45722001_1 - 0.099 12.1 0.1 0.15 11.5 0.1 1.2 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 DUF4366 PF14283.4 021689.1_45722001_1 - 0.15 11.4 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) EGF_2 PF07974.11 021689.1_45722001_1 - 4.9 7.5 9.3 0.096 12.9 1.7 2.2 2 1 0 2 2 2 0 EGF-like domain Ribosomal_S11 PF00411.17 022672.1_45721001_1 - 3.7e-47 159.1 0.4 4.9e-47 158.8 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 CBM_25 PF03423.11 022672.1_45721001_1 - 0.078 13.1 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) SR-25 PF10500.7 019158.2_45724001_2 - 0.07 12.6 31.0 0.092 12.2 31.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4604 PF15377.4 019158.2_45724001_2 - 9.5 6.5 25.7 17 5.7 25.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) MIP PF00230.18 019158.2_45724001_3 - 1e-48 165.9 12.3 1.4e-48 165.4 12.3 1.1 1 0 0 1 1 1 1 Major intrinsic protein 7tm_1 PF00001.19 001011694.1_49823001_1 - 1.8e-63 214.1 18.8 3e-63 213.4 18.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001011694.1_49823001_1 - 9.2e-18 64.4 18.9 1.3e-17 64.0 18.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 001011694.1_49823001_1 - 1.4e-10 40.8 7.5 1.4e-10 40.8 7.5 2.2 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.7 001011694.1_49823001_1 - 5.6e-08 32.3 17.7 5.6e-08 32.3 17.7 2.1 1 1 2 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx FtsK_4TM PF13491.4 001011694.1_49823001_1 - 0.0053 16.3 1.9 0.0053 16.3 1.9 2.3 1 1 2 3 3 3 1 4TM region of DNA translocase FtsK/SpoIIIE WAP PF00095.19 213947.1_49822001_1 - 5.8e-21 74.5 33.6 1.4e-11 44.5 12.8 2.2 2 0 0 2 2 2 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' Parathyroid PF01279.15 017044.1_45722001_2 - 1e-06 29.2 0.1 1.4e-06 28.7 0.1 1.2 1 0 0 1 1 1 1 Parathyroid hormone family Flu_M1_C PF08289.9 017044.1_45722001_2 - 0.13 12.3 0.9 0.24 11.5 0.9 1.4 1 0 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain ORC2 PF04084.12 001012003.1_45724001_2 - 1.1e-106 356.4 0.8 1.8e-106 355.6 0.8 1.4 1 0 0 1 1 1 1 Origin recognition complex subunit 2 HSP20 PF00011.19 130431.1_45722001_1 - 3.8e-17 62.2 0.0 4.9e-17 61.8 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Crystallin PF00525.16 130431.1_45722001_1 - 2.3e-05 24.4 0.1 4.3e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 Alpha crystallin A chain, N terminal 7tm_1 PF00001.19 001009247.1_22423001_1 - 9.9e-72 241.2 14.6 1.3e-71 240.9 14.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001009247.1_22423001_1 - 2.6e-14 53.1 16.6 3.6e-14 52.6 16.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001009247.1_22423001_1 - 2.5e-08 33.8 9.5 2.5e-08 33.8 9.5 2.1 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001009247.1_22423001_1 - 3.4e-06 26.5 16.9 6.6e-06 25.5 16.9 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Homeobox PF00046.27 001009335.1_39523001_1 - 1.2e-20 72.9 7.9 2.2e-20 72.1 7.9 1.4 1 0 0 1 1 1 1 Homeobox domain LEM PF03020.13 001047901.1_45726001_2 - 3.8e-09 35.8 0.0 1.3e-08 34.1 0.0 1.9 1 0 0 1 1 1 1 LEM domain Ank_5 PF13857.4 001047901.1_45726001_2 - 5.8e-08 32.8 0.0 0.022 15.0 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 001047901.1_45726001_2 - 3.7e-05 24.1 0.0 0.00096 19.6 0.0 2.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Cauli_VI PF01693.14 001047901.1_45726001_2 - 0.00011 22.2 0.0 0.00027 21.1 0.0 1.6 1 0 0 1 1 1 1 Caulimovirus viroplasmin Ank_4 PF13637.4 001047901.1_45726001_2 - 0.00058 20.2 0.1 0.0022 18.4 0.1 2.1 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 001047901.1_45726001_2 - 0.0058 16.9 0.1 0.072 13.5 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.28 001047901.1_45726001_2 - 0.027 14.8 0.1 0.25 11.8 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeat Telomere_Sde2_2 PF13297.4 001047901.1_45726001_2 - 0.1 12.1 0.3 0.52 9.9 0.1 2.2 2 0 0 2 2 2 0 Telomere stability C-terminal Anti-TRAP PF15777.3 031834.1_45723001_2 - 0.17 11.7 2.7 0.36 10.7 2.7 1.5 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein Sulfotransfer_1 PF00685.25 031834.1_45723001_3 - 2.1e-87 292.8 0.0 2.6e-87 292.6 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 031834.1_45723001_3 - 2.9e-09 37.5 0.0 3e-06 27.7 0.0 2.2 1 1 1 2 2 2 2 Sulfotransferase family CEP19 PF14933.4 031834.1_45723001_3 - 0.089 13.0 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 CEP19-like protein Cadherin PF00028.15 001037159.1_45729001_2 - 1.6e-77 255.9 0.0 2.1e-18 66.4 0.0 6.4 6 0 0 6 6 6 5 Cadherin domain Cadherin_2 PF08266.10 001037159.1_45729001_2 - 1.4e-29 101.6 0.0 3.1e-27 94.1 0.0 4.2 5 0 0 5 5 5 1 Cadherin-like Cadherin_tail PF15974.3 001037159.1_45729001_2 - 8.8e-26 90.7 2.8 1.6e-25 89.8 2.8 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 001037159.1_45729001_2 - 3e-16 59.8 1.9 8.3e-16 58.4 1.9 1.8 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001037159.1_45729001_2 - 1e-06 28.6 1.8 0.83 9.6 0.0 5.3 5 0 0 5 5 5 2 Cadherin-like Ubiquitin_3 PF14836.4 001009972.1_45723001_2 - 1.9e-43 146.1 0.0 4.4e-43 144.9 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin-like domain AMP-binding PF00501.26 053580.2_45727001_1 - 1.3e-68 231.4 0.0 1.6e-68 231.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 053580.2_45727001_1 - 2.2e-06 28.4 0.0 4.4e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain SNF PF00209.16 203334.1_45729001_2 - 8.8e-215 714.2 42.0 1.6e-214 713.4 42.0 1.4 1 1 0 1 1 1 1 Sodium:neurotransmitter symporter family OST3_OST6 PF04756.11 001004212.1_45724001_3 - 7.6e-109 363.4 0.2 9.3e-109 363.2 0.2 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin PF00085.18 001004212.1_45724001_3 - 3.3e-05 23.6 0.0 4.9e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin MPC PF03650.11 133561.1_45722001_1 - 2.6e-33 114.3 0.0 4.2e-33 113.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) IL1 PF00340.17 213997.1_49822001_1 - 8.9e-34 115.6 0.7 1.6e-33 114.8 0.7 1.4 1 0 0 1 1 1 1 Interleukin-1 / 18 SVS_QK PF10578.7 012710.2_45724001_1 - 1.8e-28 95.8 208.6 0.0023 18.2 2.2 23.2 23 2 1 24 24 24 17 Seminal vesicle protein repeat SR-25 PF10500.7 012710.2_45724001_3 - 0.017 14.6 16.9 0.022 14.3 16.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Glyco_hydro_63 PF03200.14 031749.2_45726001_1 - 3.7e-195 649.2 0.0 4.4e-195 649.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.3 031749.2_45726001_1 - 4.1e-48 164.3 0.2 7.2e-48 163.5 0.0 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 63 N-terminal domain GDE_C PF06202.12 031749.2_45726001_1 - 0.0033 16.3 0.1 0.006 15.4 0.1 1.3 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase PPTA PF01239.20 012847.1_45724001_3 - 1.9e-46 154.4 20.0 1.1e-11 43.9 0.5 5.8 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat CAP_N PF01213.17 012847.1_45724001_3 - 0.16 11.3 9.4 0.33 10.2 9.4 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DAP10 PF07213.9 212525.1_45722001_1 - 0.00052 19.8 0.6 0.00085 19.1 0.6 1.3 1 0 0 1 1 1 1 DAP10 membrane protein ASC PF00858.22 031548.2_45727001_3 - 2.4e-100 336.2 11.1 2.9e-100 335.9 11.1 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Ion_trans PF00520.29 173095.3_45724001_2 - 8.3e-51 172.4 13.4 1.1e-50 172.0 13.4 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 173095.3_45724001_2 - 9.3e-29 99.5 0.3 2.2e-28 98.3 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain Ion_trans_2 PF07885.14 173095.3_45724001_2 - 6.7e-14 51.5 5.3 6.7e-14 51.5 5.3 2.7 3 0 0 3 3 3 1 Ion channel PKD_channel PF08016.10 173095.3_45724001_2 - 0.0034 16.0 0.8 0.0034 16.0 0.8 1.5 1 1 0 1 1 1 1 Polycystin cation channel Sigma_reg_N PF13800.4 173095.3_45724001_2 - 0.54 10.4 8.0 3 8.1 0.1 3.7 4 0 0 4 4 4 0 Sigma factor regulator N-terminal CSD PF00313.20 152790.2_45727001_1 - 4e-11 42.5 0.0 6.2e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.9 152790.2_45727001_1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Ribonuclease B OB domain zf-RING_UBOX PF13445.4 001012218.1_45726001_3 - 1.2e-09 37.9 3.9 3.1e-09 36.6 3.9 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 001012218.1_45726001_3 - 4.9e-08 32.5 2.3 4.9e-08 32.5 2.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001012218.1_45726001_3 - 1.3e-07 31.2 3.7 1.3e-07 31.2 3.7 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001012218.1_45726001_3 - 1e-06 28.8 4.6 1e-06 28.8 4.6 2.6 2 0 0 2 2 1 1 Ring finger domain zf-B_box PF00643.22 001012218.1_45726001_3 - 1e-06 28.6 6.4 1e-06 28.6 6.4 3.5 5 0 0 5 5 3 1 B-box zinc finger zf-RING_5 PF14634.4 001012218.1_45726001_3 - 2.6e-06 27.2 4.7 2.6e-06 27.2 4.7 2.2 2 0 0 2 2 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 001012218.1_45726001_3 - 1.7e-05 24.5 6.7 1.7e-05 24.5 6.7 3.0 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001012218.1_45726001_3 - 4.3e-05 23.5 6.7 4.3e-05 23.5 6.7 2.8 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.4 001012218.1_45726001_3 - 5.4e-05 22.8 0.4 5.4e-05 22.8 0.4 2.0 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_11 PF17123.3 001012218.1_45726001_3 - 5.7 6.6 9.8 3.2 7.4 6.2 2.5 2 0 0 2 2 2 0 RING-like zinc finger DNA_topoisoIV PF00521.18 001012218.1_45726001_3 - 8.2 5.0 9.8 2.5 6.7 5.3 1.9 1 1 1 2 2 2 0 DNA gyrase/topoisomerase IV, subunit A 7tm_4 PF13853.4 001000465.1_45722001_1 - 1.3e-47 162.8 16.6 1.5e-47 162.5 16.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001000465.1_45722001_1 - 3.6e-21 75.5 20.4 6.7e-21 74.6 20.4 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) MIF4G_like_2 PF09090.9 001014785.1_45726001_1 - 1.2e-84 283.8 5.5 2.5e-84 282.7 5.5 1.6 1 0 0 1 1 1 1 MIF4G like MIF4G_like PF09088.9 001014785.1_45726001_1 - 8.4e-36 123.3 0.5 1.1e-34 119.7 0.4 2.4 2 0 0 2 2 2 1 MIF4G like MIF4G PF02854.17 001014785.1_45726001_1 - 3.3e-31 108.5 3.1 1.7e-30 106.2 0.0 3.1 3 1 0 3 3 3 1 MIF4G domain Mnd1 PF03962.13 001014785.1_45726001_1 - 0.0068 16.2 0.7 0.018 14.8 0.7 1.7 1 0 0 1 1 1 1 Mnd1 family DUF1690 PF07956.9 001014785.1_45726001_1 - 0.035 14.4 2.0 0.091 13.0 2.0 1.7 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) IDO PF01231.16 001014785.1_45726001_1 - 0.12 11.0 1.0 0.21 10.2 1.0 1.3 1 0 0 1 1 1 0 Indoleamine 2,3-dioxygenase DUF2524 PF10732.7 001014785.1_45726001_1 - 0.79 9.9 5.1 1.2 9.4 2.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) FlxA PF14282.4 001014785.1_45726001_1 - 4.1 7.3 11.4 0.82 9.6 7.2 1.9 2 0 0 2 2 2 0 FlxA-like protein Agouti PF05039.10 001011648.1_49822001_3 - 1.6e-28 99.1 15.2 3.3e-28 98.1 15.2 1.5 1 0 0 1 1 1 1 Agouti protein Toxin_9 PF02819.13 001011648.1_49822001_3 - 0.033 14.3 12.9 0.073 13.2 12.9 1.5 1 0 0 1 1 1 0 Spider toxin ETRAMP PF09716.8 001011648.1_49822001_3 - 0.045 13.7 1.2 0.081 12.9 1.2 1.4 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) RRF PF01765.17 001008354.1_45728001_2 - 1.1e-40 139.1 7.7 1.6e-40 138.6 7.7 1.2 1 0 0 1 1 1 1 Ribosome recycling factor DUF883 PF05957.11 001008354.1_45728001_2 - 0.14 12.6 4.3 0.39 11.2 4.3 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) 14-3-3 PF00244.18 001008354.1_45728001_2 - 0.5 9.7 5.8 0.16 11.3 2.4 1.7 2 0 0 2 2 2 0 14-3-3 protein Syntaxin-6_N PF09177.9 001004264.1_45723001_1 - 6.3 7.3 10.6 0.58 10.6 2.0 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal CH_2 PF06294.9 001002852.1_45723001_2 - 4.5e-35 119.5 0.0 1.2e-34 118.2 0.0 1.7 1 0 0 1 1 1 1 CH-like domain in sperm protein CAMSAP_CH PF11971.6 001002852.1_45723001_2 - 1.8e-09 37.1 0.0 4.4e-09 35.9 0.0 1.7 1 0 0 1 1 1 1 CAMSAP CH domain Proteasome PF00227.24 001008217.1_45722001_1 - 1.8e-63 213.4 0.2 2.3e-63 213.0 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.7 001008217.1_45722001_1 - 1.6e-14 53.1 0.5 3.8e-14 51.9 0.2 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature DUF1192 PF06698.9 001008217.1_45722001_1 - 0.11 12.4 2.1 0.4 10.6 2.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Hormone_3 PF00159.16 001008217.1_45722001_1 - 0.22 11.5 0.5 6.5 6.8 0.1 2.3 2 0 0 2 2 2 0 Pancreatic hormone peptide Yae1_N PF09811.7 153728.2_45725001_1 - 0.17 11.4 2.5 0.32 10.6 2.5 1.4 1 0 0 1 1 1 0 Essential protein Yae1, N terminal MBOAT PF03062.17 153728.2_45725001_2 - 2e-55 188.4 23.6 2.6e-55 188.0 23.6 1.1 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Yae1_N PF09811.7 153728.2_45725001_2 - 0.04 13.5 2.5 0.084 12.5 2.5 1.6 1 0 0 1 1 1 0 Essential protein Yae1, N terminal MBOAT_2 PF13813.4 153728.2_45725001_2 - 0.052 13.7 4.4 0.14 12.3 4.4 1.7 1 0 0 1 1 1 0 Membrane bound O-acyl transferase family BBS2_C PF14782.4 001012180.1_45726001_1 - 2.5e-05 23.1 0.4 6.2e-05 21.8 0.1 1.8 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, C-terminal BBS2_Mid PF14783.4 001012180.1_45726001_1 - 0.00086 19.2 0.0 0.0031 17.4 0.0 2.0 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, middle region FlxA PF14282.4 001012180.1_45726001_1 - 0.019 14.8 2.0 0.042 13.7 2.0 1.5 1 0 0 1 1 1 0 FlxA-like protein ANAPC4_WD40 PF12894.5 001012180.1_45726001_1 - 0.058 13.6 0.0 10 6.4 0.0 3.4 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain VCBS PF13517.4 001012180.1_45726001_1 - 0.24 11.9 1.4 4.2 7.9 0.2 2.9 2 1 1 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DUF1977 PF09320.9 001013907.1_45727001_3 - 4e-27 94.4 0.1 4e-27 94.4 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1977) DnaJ PF00226.29 001013907.1_45727001_3 - 1.3e-26 92.3 0.5 2.4e-26 91.5 0.5 1.5 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.15 001013907.1_45727001_3 - 0.061 13.3 0.0 0.18 11.9 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat Galanin PF01296.16 022633.1_45722001_3 - 6.7e-07 29.0 1.9 1.3e-06 28.1 1.9 1.5 1 0 0 1 1 1 1 Galanin CTD_bind PF04818.11 139094.1_45729001_2 - 1.3e-16 61.0 0.1 3.7e-16 59.5 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_1 PF00076.20 139094.1_45729001_2 - 1.3e-08 34.4 0.0 2.2e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3525 PF12039.6 139094.1_45729001_2 - 0.065 11.8 0.1 0.1 11.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3525) SVA PF05326.9 001009170.1_39721001_1 - 1.9e-53 179.6 0.5 2.2e-53 179.4 0.5 1.0 1 0 0 1 1 1 1 Seminal vesicle autoantigen (SVA) Pkinase PF00069.23 021699.1_45726001_3 - 1.7e-76 256.9 0.0 2.4e-76 256.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 021699.1_45726001_3 - 4.4e-45 153.9 0.0 7.9e-45 153.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.17 021699.1_45726001_3 - 5.3e-21 74.0 0.0 1.4e-20 72.7 0.0 1.8 2 0 0 2 2 2 1 Kinase associated domain 1 Kinase-like PF14531.4 021699.1_45726001_3 - 5.8e-07 29.0 0.0 1.3e-06 27.8 0.0 1.6 2 0 0 2 2 2 1 Kinase-like UBA PF00627.29 021699.1_45726001_3 - 1.7e-05 24.4 0.0 3e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain UBA_2 PF08587.9 021699.1_45726001_3 - 0.0008 19.4 0.1 0.002 18.1 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) RIO1 PF01163.20 021699.1_45726001_3 - 0.00084 18.9 0.3 0.0017 17.8 0.3 1.5 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.12 021699.1_45726001_3 - 0.0096 15.2 0.1 0.019 14.2 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_S8 PF00082.20 001004044.1_49825001_1 - 3.8e-42 144.4 1.9 5e-42 144.0 1.9 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.18 001004044.1_49825001_1 - 1.8e-25 88.7 0.1 3.4e-25 87.8 0.1 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.3 001004044.1_49825001_1 - 5.4e-19 68.7 3.9 1.3e-18 67.5 3.9 1.7 1 0 0 1 1 1 1 Peptidase S8 pro-domain Peptidase_S8_N PF16361.3 001004044.1_49825001_1 - 0.032 14.6 0.0 0.064 13.6 0.0 1.5 1 0 0 1 1 1 0 N-terminal of Subtilase family Xlink PF00193.15 022285.1_45723001_2 - 5e-58 193.4 0.0 1.8e-31 108.3 0.0 2.2 2 0 0 2 2 2 2 Extracellular link domain V-set PF07686.15 022285.1_45723001_2 - 3.3e-13 49.6 0.0 5.1e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 022285.1_45723001_2 - 6.5e-08 32.9 0.0 1.4e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 022285.1_45723001_2 - 2.5e-05 24.2 0.0 5.3e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 022285.1_45723001_2 - 3.7e-05 23.6 0.0 7.9e-05 22.5 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 022285.1_45723001_2 - 0.00013 22.1 0.0 0.00065 19.9 0.0 2.0 1 1 0 1 1 1 1 Immunoglobulin domain Izumo-Ig PF16706.3 022285.1_45723001_2 - 0.0035 17.2 0.0 0.0063 16.4 0.0 1.3 1 0 0 1 1 1 1 Izumo-like Immunoglobulin domain S_100 PF01023.17 001008536.1_26228001_3 - 2e-14 52.9 0.1 1e-13 50.6 0.0 2.2 2 0 0 2 2 2 1 S-100/ICaBP type calcium binding domain Kunitz_BPTI PF00014.21 001004265.2_45725001_3 - 1.2e-32 111.8 26.9 3.4e-16 59.1 12.0 2.9 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain MANEC PF07502.12 001004265.2_45725001_3 - 1.1e-26 92.7 0.9 1.1e-26 92.7 0.9 3.5 3 1 1 4 4 4 1 MANEC domain Ldl_recept_a PF00057.16 001004265.2_45725001_3 - 2.8e-09 36.9 15.1 8.6e-09 35.3 15.1 1.9 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Chordopox_A13L PF05961.9 001004265.2_45725001_3 - 0.16 12.1 0.1 0.66 10.1 0.0 2.0 2 0 0 2 2 2 0 Chordopoxvirus A13L protein Cofilin_ADF PF00241.18 181091.2_45722001_3 - 4.2e-30 104.4 0.2 4.9e-30 104.2 0.2 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein MHC_I PF00129.16 033351.2_45724001_2 - 1.1e-58 197.6 0.0 1.4e-58 197.3 0.0 1.1 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 033351.2_45724001_2 - 1.3e-10 41.5 0.0 2.5e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.3 033351.2_45724001_2 - 3.8e-05 23.1 0.1 5.3e-05 22.6 0.1 1.2 1 0 0 1 1 1 1 MHC-I family domain Ig_3 PF13927.4 033351.2_45724001_2 - 0.00061 20.2 0.1 0.0055 17.2 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain Cytochrome_B PF00033.17 033351.2_45724001_2 - 0.081 12.6 0.1 0.13 11.9 0.1 1.2 1 0 0 1 1 1 0 Cytochrome b/b6/petB SIR2 PF02146.15 001004256.1_45723001_3 - 6.2e-47 159.6 0.0 1.3e-46 158.6 0.0 1.5 1 1 0 1 1 1 1 Sir2 family PNTB PF02233.14 001004256.1_45723001_3 - 0.00012 21.0 0.0 0.0018 17.1 0.0 2.0 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit TPP_enzyme_M PF00205.20 001004256.1_45723001_3 - 0.027 14.1 0.0 1.5 8.4 0.0 2.4 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain RseA_N PF03872.11 001004256.1_45723001_3 - 0.18 12.2 0.0 0.32 11.4 0.0 1.3 1 0 0 1 1 1 0 Anti sigma-E protein RseA, N-terminal domain Defensin_propep PF00879.16 173299.2_45721001_2 - 3e-19 69.0 0.2 4.2e-19 68.5 0.2 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 173299.2_45721001_2 - 1.4e-09 38.2 14.1 1.4e-09 38.2 14.1 2.0 2 0 0 2 2 2 1 Mammalian defensin DUF4131 PF13567.4 173299.2_45721001_2 - 0.092 12.2 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) XLF PF09302.9 001014217.1_45723001_1 - 5.9e-37 127.4 0.1 9.4e-37 126.8 0.1 1.3 1 0 0 1 1 1 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component Tropomyosin PF00261.18 173111.1_45724001_1 - 6.5e-86 287.4 60.9 7.8e-86 287.2 60.9 1.0 1 0 0 1 1 1 1 Tropomyosin Tropomyosin_1 PF12718.5 173111.1_45724001_1 - 8.1e-23 81.0 56.8 8.6e-19 68.0 28.0 3.1 1 1 2 3 3 3 3 Tropomyosin like Laminin_II PF06009.10 173111.1_45724001_1 - 1.6e-05 24.8 24.5 7.2e-05 22.7 3.7 3.3 1 1 1 3 3 3 2 Laminin Domain II TMF_DNA_bd PF12329.6 173111.1_45724001_1 - 0.0023 17.7 11.4 0.0023 17.7 11.4 4.5 2 1 1 4 4 4 2 TATA element modulatory factor 1 DNA binding WES_acyltransf PF03007.14 173111.1_45724001_1 - 0.19 11.3 3.2 0.3 10.7 3.2 1.3 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain CENP-F_leu_zip PF10473.7 173111.1_45724001_1 - 0.39 10.6 53.8 0.089 12.7 30.2 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF745 PF05335.11 173111.1_45724001_1 - 0.76 9.4 34.0 0.37 10.4 23.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Fib_alpha PF08702.8 173111.1_45724001_1 - 1.6 8.8 22.9 1.4 8.9 7.4 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family CALCOCO1 PF07888.9 173111.1_45724001_1 - 1.8 6.9 42.2 2.3 6.5 42.2 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF1664 PF07889.10 173111.1_45724001_1 - 1.9 8.4 22.4 1.6 8.6 4.5 3.3 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) Golgin_A5 PF09787.7 173111.1_45724001_1 - 3.2 7.0 46.2 0.044 13.1 14.3 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 MAD PF05557.11 173111.1_45724001_1 - 3.8 5.6 45.8 0.99 7.5 24.7 2.0 1 1 1 2 2 2 0 Mitotic checkpoint protein CLZ PF16526.3 173111.1_45724001_1 - 4.2 7.7 36.1 0.064 13.5 3.7 4.7 2 2 3 5 5 5 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Alanine_zipper PF11839.6 173111.1_45724001_1 - 7.7 6.7 30.0 2.2 8.4 12.5 4.2 1 1 2 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein FEZ PF07763.11 031066.1_45724001_2 - 5.8e-81 271.6 21.5 7.7e-81 271.2 21.5 1.1 1 0 0 1 1 1 1 FEZ-like protein EURL PF06937.9 031066.1_45724001_2 - 0.0026 17.1 1.4 0.0047 16.2 1.4 1.5 1 1 0 1 1 1 1 EURL protein DUF5102 PF17104.3 031066.1_45724001_2 - 0.026 14.4 9.8 0.024 14.6 2.3 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF5102) RPEL PF02755.13 213745.1_49826001_1 - 3e-10 39.3 5.9 6.2e-07 28.8 0.3 3.5 3 0 0 3 3 3 2 RPEL repeat SAP PF02037.25 213745.1_49826001_1 - 5.5e-10 38.6 0.1 5.5e-10 38.6 0.1 1.9 2 0 0 2 2 2 1 SAP domain TMEM52 PF14979.4 213745.1_49826001_1 - 0.22 11.3 0.9 0.63 9.8 0.9 1.7 1 0 0 1 1 1 0 Transmembrane 52 DUF2570 PF10828.6 213745.1_49826001_1 - 7.1 6.4 10.0 0.11 12.3 0.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) Radical_SAM PF04055.19 213817.1_49826001_2 - 5.8e-14 52.7 0.1 2.1e-13 50.9 0.1 1.8 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.4 213817.1_49826001_2 - 2.8e-07 30.6 0.6 4e-06 26.8 0.0 2.4 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_12 PF13353.4 213817.1_49826001_2 - 1.1e-06 28.9 0.2 2.6e-06 27.6 0.2 1.6 2 0 0 2 2 2 1 4Fe-4S single cluster domain PP2C PF00481.19 147209.2_45725001_2 - 2.4e-74 250.1 0.4 5.1e-57 193.3 0.6 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.4 147209.2_45725001_2 - 0.024 14.1 0.0 0.064 12.8 0.0 1.7 1 1 0 1 1 1 0 Protein phosphatase 2C Cwf_Cwc_15 PF04889.10 147209.2_45725001_2 - 0.49 9.9 24.6 0.41 10.2 2.2 2.5 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein FPP PF05911.9 033485.2_45725001_1 - 0.0012 17.1 10.1 0.0018 16.5 10.1 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil ATG16 PF08614.9 033485.2_45725001_1 - 0.0041 17.2 13.9 0.0041 17.2 13.9 1.7 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) IncA PF04156.12 033485.2_45725001_1 - 0.038 13.6 5.3 0.063 12.9 5.3 1.3 1 0 0 1 1 1 0 IncA protein Fib_alpha PF08702.8 033485.2_45725001_1 - 0.15 12.1 3.4 0.15 12.1 2.1 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF724 PF05266.12 033485.2_45725001_1 - 0.16 11.6 3.6 0.27 10.9 3.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) PRKG1_interact PF15898.3 033485.2_45725001_1 - 0.51 11.1 17.3 0.032 15.0 9.4 2.8 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF972 PF06156.11 033485.2_45725001_1 - 0.52 10.8 5.6 0.9 10.1 4.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF972) DUF1192 PF06698.9 033485.2_45725001_1 - 1.1 9.2 4.3 3.5 7.6 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) FAM76 PF16046.3 033485.2_45725001_1 - 2.4 7.3 5.2 3.4 6.8 5.2 1.1 1 0 0 1 1 1 0 FAM76 protein Pro_isomerase PF00160.19 001004279.1_45723001_1 - 3e-47 160.7 0.1 4e-47 160.3 0.1 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.26 001004279.1_45723001_1 - 7.2e-17 60.3 2.0 6.3e-05 22.5 0.4 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.15 001004279.1_45723001_1 - 7.5e-14 50.5 0.3 0.00087 19.1 0.5 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.4 001004279.1_45723001_1 - 4.4e-08 32.5 0.1 0.0031 17.3 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.4 001004279.1_45723001_1 - 2.5e-06 27.6 0.4 0.96 9.6 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.4 001004279.1_45723001_1 - 1.3e-05 24.6 1.6 0.72 9.5 0.0 3.6 3 0 0 3 3 3 2 TPR repeat TPR_14 PF13428.4 001004279.1_45723001_1 - 0.0022 18.5 0.3 3.1 8.7 1.1 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 001004279.1_45723001_1 - 0.018 15.1 6.0 0.35 11.1 0.2 3.8 4 1 1 5 5 4 0 Tetratricopeptide repeat TPR_9 PF13371.4 001004279.1_45723001_1 - 0.035 14.1 0.0 0.072 13.1 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.4 001004279.1_45723001_1 - 0.045 14.3 0.0 0.35 11.5 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.4 001004279.1_45723001_1 - 0.06 13.7 2.1 0.29 11.5 2.0 2.1 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_17 PF13431.4 001004279.1_45723001_1 - 0.098 13.0 0.1 0.39 11.1 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.5 001004279.1_45723001_1 - 0.11 12.6 0.9 3.2 7.9 0.2 2.4 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.4 001004279.1_45723001_1 - 0.27 11.8 4.3 22 5.8 0.5 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Cullin PF00888.20 022683.1_45726001_3 - 4.8e-186 619.9 18.4 6.7e-186 619.4 18.4 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.7 022683.1_45726001_3 - 3.1e-18 65.4 7.0 9.5e-18 63.9 7.0 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain Stork_head PF10264.7 022683.1_45726001_3 - 0.036 14.1 1.5 0.077 13.0 0.6 2.0 2 0 0 2 2 2 0 Winged helix Storkhead-box1 domain Uteroglobin PF01099.15 001024283.1_45721001_3 - 8.8e-08 32.1 0.1 1.2e-07 31.7 0.1 1.2 1 0 0 1 1 1 1 Uteroglobin family IL8 PF00048.18 214214.1_49822001_2 - 4.4e-22 77.9 2.8 6.8e-22 77.3 2.8 1.3 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Cyclin_N PF00134.21 001009054.1_39725001_1 - 3.3e-22 78.5 0.5 5.2e-19 68.2 0.0 2.7 2 0 0 2 2 2 2 Cyclin, N-terminal domain NUFIP1 PF10453.7 001007758.1_45724001_1 - 6.9e-21 73.7 4.0 6.9e-21 73.7 4.0 3.0 4 0 0 4 4 4 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-C2H2_jaz PF12171.6 001007758.1_45724001_1 - 0.00033 20.8 4.0 0.00033 20.8 4.0 2.5 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.24 001007758.1_45724001_1 - 0.012 15.9 0.8 0.012 15.9 0.8 2.5 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001007758.1_45724001_1 - 0.037 14.7 9.7 0.6 11.0 0.3 3.8 2 1 1 3 3 3 0 C2H2-type zinc finger zf-met PF12874.5 001007758.1_45724001_1 - 0.26 11.6 3.5 0.29 11.5 0.2 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Sclerostin PF05463.9 153737.1_45724001_1 - 5.7e-106 352.4 6.2 5.7e-106 352.4 6.2 2.1 2 0 0 2 2 2 1 Sclerostin (SOST) DAN PF03045.13 153737.1_45724001_1 - 4e-13 49.2 2.0 4e-13 49.2 2.0 1.6 2 0 0 2 2 2 1 DAN domain Cys_knot PF00007.20 153737.1_45724001_1 - 6.3e-05 23.1 6.8 0.00026 21.1 6.8 2.0 1 1 0 1 1 1 1 Cystine-knot domain Kinesin PF00225.21 145877.1_45729001_2 - 2.4e-107 358.6 0.2 3.1e-107 358.2 0.2 1.1 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.3 145877.1_45729001_2 - 3.9e-60 203.0 0.3 1.8e-59 200.8 0.3 2.2 1 1 0 1 1 1 1 Kinesin-associated Microtub_bd PF16796.3 145877.1_45729001_2 - 6e-21 74.8 0.1 1.1e-20 74.0 0.1 1.4 1 0 0 1 1 1 1 Microtubule binding FHA PF00498.24 145877.1_45729001_2 - 2.2e-05 24.6 0.0 6.9e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 FHA domain Sigma70_ner PF04546.11 145877.1_45729001_2 - 0.18 11.6 2.4 0.55 9.9 0.0 2.6 3 0 0 3 3 3 0 Sigma-70, non-essential region Cupin_4 PF08007.10 153309.2_45725001_2 - 1.3e-97 327.0 0.0 1.6e-97 326.7 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.4 153309.2_45725001_2 - 5e-06 26.4 0.0 0.015 15.0 0.0 2.3 1 1 0 2 2 2 2 Cupin-like domain Cupin_2 PF07883.9 153309.2_45725001_2 - 0.00089 18.8 0.0 0.038 13.6 0.0 2.4 1 1 0 1 1 1 1 Cupin domain AraC_binding PF02311.17 153309.2_45725001_2 - 0.044 13.6 0.1 0.12 12.1 0.1 1.8 1 1 0 1 1 1 0 AraC-like ligand binding domain Pkinase PF00069.23 053677.1_45724001_3 - 1.3e-74 250.8 0.0 1.7e-74 250.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 053677.1_45724001_3 - 3.7e-32 111.5 0.0 5.5e-32 110.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.24 053677.1_45724001_3 - 2.4e-12 46.9 0.0 5.9e-12 45.6 0.0 1.7 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.4 053677.1_45724001_3 - 1.1e-06 28.0 0.0 1.6e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 053677.1_45724001_3 - 0.00058 19.4 0.1 0.00099 18.6 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.12 053677.1_45724001_3 - 0.0047 16.2 0.0 0.0077 15.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 053677.1_45724001_3 - 0.023 14.5 0.0 0.27 11.0 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.7 053677.1_45724001_3 - 0.096 12.1 0.0 0.22 10.9 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Apt1 PF10351.7 053677.1_45724001_3 - 9.5 4.8 7.3 13 4.3 7.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain CSF-1 PF05337.9 023981.4_45728001_2 - 2.1e-78 261.1 7.5 3.1e-78 260.5 7.5 1.2 1 0 0 1 1 1 1 Macrophage colony stimulating factor-1 (CSF-1) FMO-like PF00743.17 144561.2_45725001_1 - 1.7e-269 894.5 0.0 2e-269 894.3 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.4 144561.2_45725001_1 - 6.1e-15 55.1 0.0 9.4e-12 44.6 0.0 2.6 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.4 144561.2_45725001_1 - 1.9e-12 46.9 0.0 3.3e-10 39.5 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.12 144561.2_45725001_1 - 1.7e-10 40.5 0.0 1.3e-09 37.6 0.0 2.2 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 144561.2_45725001_1 - 0.00011 21.8 0.0 0.04 13.4 0.0 2.5 3 0 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.4 144561.2_45725001_1 - 0.00065 19.8 0.0 0.0018 18.3 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.25 144561.2_45725001_1 - 0.0025 18.2 0.5 1.4 9.4 0.4 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.4 144561.2_45725001_1 - 0.0047 16.8 0.0 0.035 14.0 0.0 2.5 2 1 0 2 2 2 1 FAD-NAD(P)-binding 2-Hacid_dh_C PF02826.17 144561.2_45725001_1 - 0.021 14.1 0.0 0.11 11.7 0.1 2.0 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.19 144561.2_45725001_1 - 0.065 12.4 0.0 0.37 9.9 0.0 1.9 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Bax1-I PF01027.18 199116.2_45722001_1 - 2.8e-48 164.3 27.8 3.3e-48 164.1 27.8 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 7TMR-DISM_7TM PF07695.9 199116.2_45722001_1 - 1.7 8.3 28.2 4.4 7.0 11.7 2.1 1 1 1 2 2 2 0 7TM diverse intracellular signalling UPAR_LY6 PF00021.19 001001972.1_45722001_3 - 0.0014 19.1 11.1 0.0021 18.6 11.1 1.3 1 0 0 1 1 1 1 u-PAR/Ly-6 domain Activin_recp PF01064.21 001001972.1_45722001_3 - 0.0073 17.2 10.3 0.012 16.6 10.3 1.3 1 0 0 1 1 1 1 Activin types I and II receptor domain UPAR_LY6_2 PF16975.3 001001972.1_45722001_3 - 0.15 12.1 7.9 0.42 10.7 7.9 1.7 1 1 0 1 1 1 0 Ly6/PLAUR domain-containing protein 6, Lypd6 Toxin_1 PF00087.19 001001972.1_45722001_3 - 1.3 9.2 10.5 2 8.6 10.5 1.3 1 0 0 1 1 1 0 Snake toxin LIM PF00412.20 031677.1_45722001_1 - 4.4e-47 158.0 66.2 5e-13 48.9 8.1 5.1 5 0 0 5 5 5 5 LIM domain zf-ribbon_3 PF13248.4 031677.1_45722001_1 - 0.049 12.9 0.2 0.049 12.9 0.2 8.9 12 0 0 12 12 12 0 zinc-ribbon domain zf-RING_2 PF13639.4 001011904.1_45727001_2 - 4.4e-07 29.9 9.9 9.6e-07 28.8 9.9 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.23 001011904.1_45727001_2 - 5.1e-07 29.3 8.4 1.2e-06 28.1 8.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001011904.1_45727001_2 - 4e-06 26.5 6.5 7.3e-06 25.6 6.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001011904.1_45727001_2 - 7.2e-06 25.8 5.7 7.2e-06 25.8 5.7 2.8 2 1 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.4 001011904.1_45727001_2 - 1e-05 25.3 6.5 2.4e-05 24.1 6.5 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.4 001011904.1_45727001_2 - 3.2e-05 23.5 8.6 8.6e-05 22.2 8.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 001011904.1_45727001_2 - 0.00045 19.9 6.8 0.0012 18.5 6.7 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.4 001011904.1_45727001_2 - 0.02 14.6 3.3 0.27 11.0 4.3 2.2 2 1 0 2 2 2 0 zf-RING of BARD1-type protein GCS2 PF04107.11 001011904.1_45727001_2 - 0.026 13.8 0.1 0.042 13.1 0.1 1.2 1 0 0 1 1 1 0 Glutamate-cysteine ligase family 2(GCS2) zf-ANAPC11 PF12861.5 001011904.1_45727001_2 - 0.042 13.8 5.4 0.078 12.9 5.4 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.4 001011904.1_45727001_2 - 0.22 11.6 13.8 0.025 14.6 9.0 2.1 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.5 001011904.1_45727001_2 - 0.25 11.5 10.0 0.5 10.6 10.0 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain TBP PF00352.19 001004198.1_45724001_2 - 3.4e-65 215.9 0.3 1.2e-31 108.4 0.1 2.3 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3365 PF11845.6 001004198.1_45724001_2 - 0.049 13.8 1.3 0.076 13.2 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3365) L27 PF02828.14 021851.1_45722001_1 - 3.4e-23 81.0 0.4 7e-23 80.0 0.2 1.7 2 0 0 2 2 2 1 L27 domain PDZ PF00595.22 021851.1_45722001_1 - 5e-21 74.7 0.6 7.4e-21 74.2 0.6 1.2 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 021851.1_45722001_1 - 0.0032 17.6 0.0 0.0055 16.9 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Complex1_LYR_2 PF13233.4 021851.1_45722001_1 - 0.065 13.8 0.0 0.17 12.5 0.0 1.7 1 1 0 1 1 1 0 Complex1_LYR-like His_Phos_2 PF00328.20 021851.1_45722001_1 - 0.088 12.0 0.0 0.092 11.9 0.0 1.3 1 1 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) PMP22_Claudin PF00822.18 030847.1_45722001_1 - 6.4e-44 149.6 14.9 7.5e-44 149.4 14.9 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 030847.1_45722001_1 - 2.7e-07 30.4 12.4 2.7e-07 30.4 12.4 2.0 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction Claudin_3 PF06653.9 030847.1_45722001_1 - 0.015 15.1 14.5 0.061 13.1 14.6 1.9 1 1 0 1 1 1 0 Tight junction protein, Claudin-like DUF2569 PF10754.7 030847.1_45722001_1 - 0.42 10.9 10.7 0.095 13.0 3.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) Comm PF15957.3 030847.1_45722001_1 - 5.7 7.2 7.4 1.7 8.9 2.6 2.1 2 0 0 2 2 2 0 Commissureless Tetraspannin PF00335.18 013021.1_45724001_3 - 1.6e-24 86.8 4.6 2.1e-24 86.4 4.6 1.1 1 0 0 1 1 1 1 Tetraspanin family UCH PF00443.27 001008301.1_45725001_3 - 9.9e-51 172.6 1.1 1.2e-50 172.3 1.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 001008301.1_45725001_3 - 2.5e-14 53.5 7.0 5.4e-14 52.4 7.0 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.21 001008301.1_45725001_3 - 0.0011 18.6 0.0 0.002 17.7 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Peptidase_C98 PF15499.4 001008301.1_45725001_3 - 0.026 13.9 2.5 0.037 13.4 0.1 2.0 2 0 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase LIM PF00412.20 001009708.1_45724001_1 - 1.2e-30 105.4 14.1 7.9e-16 57.9 1.2 2.7 2 0 0 2 2 2 2 LIM domain DUF678 PF05077.10 001009708.1_45724001_1 - 2.7 8.0 13.7 3.2 7.8 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF678) 7tm_1 PF00001.19 214034.1_49826001_3 - 2.8e-81 272.6 0.0 3.7e-81 272.2 0.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 214034.1_49826001_3 - 1.4e-05 24.5 9.5 2.3e-05 23.8 3.3 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 214034.1_49826001_3 - 0.00026 20.7 7.5 0.0013 18.4 3.4 2.1 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.7 214034.1_49826001_3 - 0.00048 19.4 6.5 0.00048 19.4 6.5 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srbc PF10316.7 214034.1_49826001_3 - 0.0015 18.0 3.6 0.0027 17.1 3.6 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc Neur_chan_LBD PF02931.21 024370.3_45724001_1 - 1.5e-49 168.2 1.4 2.2e-49 167.7 1.4 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 024370.3_45724001_1 - 1.8e-38 132.8 9.7 1.4e-37 129.9 9.7 2.1 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region CTP_transf_3 PF02348.17 001009419.1_45724001_3 - 4.6e-65 219.5 0.0 6.3e-65 219.1 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase NTP_transf_3 PF12804.5 001009419.1_45724001_3 - 1.2e-07 32.0 0.0 2e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hydrolase_3 PF08282.10 001009419.1_45724001_3 - 0.099 12.2 0.0 0.85 9.2 0.0 2.3 2 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase DUF1593 PF07632.9 001009419.1_45724001_3 - 0.13 11.5 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1593) PHO4 PF01384.18 001009840.1_22425001_2 - 2.9e-138 460.3 3.6 4.5e-138 459.7 3.6 1.3 1 0 0 1 1 1 1 Phosphate transporter family Abhydrolase_1 PF00561.18 001009617.1_45723001_2 - 1.2e-16 61.0 0.1 1.7e-14 54.0 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001009617.1_45723001_2 - 1.2e-09 39.0 0.0 1.2e-09 39.0 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF1057 PF06342.10 001009617.1_45723001_2 - 2.6e-05 23.3 0.0 3.6e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Hydrolase_4 PF12146.6 001009617.1_45723001_2 - 0.00014 21.1 0.0 0.0022 17.2 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 REV PF00424.16 001009617.1_45723001_2 - 0.0055 16.6 0.0 0.15 12.0 0.0 2.4 2 0 0 2 2 2 1 REV protein (anti-repression trans-activator protein) Phosphodiest PF01663.20 001012466.1_45723001_1 - 2.2e-75 254.4 3.6 2.5e-75 254.2 3.6 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.21 001012466.1_45723001_1 - 1.6e-09 37.5 0.3 7.2e-05 22.2 0.0 2.3 2 0 0 2 2 2 2 Sulfatase Metalloenzyme PF01676.16 001012466.1_45723001_1 - 2.7e-07 30.1 0.0 5.1e-07 29.2 0.0 1.4 1 1 0 1 1 1 1 Metalloenzyme superfamily PglZ PF08665.10 001012466.1_45723001_1 - 0.08 12.9 0.2 0.13 12.2 0.2 1.3 1 0 0 1 1 1 0 PglZ domain RabGAP-TBC PF00566.16 001015022.3_45724001_1 - 3.4e-53 180.4 0.0 5.6e-53 179.6 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain LRRCT PF01463.22 001015022.3_45724001_1 - 0.073 13.5 0.3 14 6.4 0.1 3.2 2 0 0 2 2 2 0 Leucine rich repeat C-terminal domain PAN_4 PF14295.4 001015022.3_45724001_3 - 3.7 7.4 6.8 15 5.5 1.6 2.5 2 0 0 2 2 2 0 PAN domain V-set PF07686.15 031674.1_45722001_1 - 2.2e-15 56.6 0.0 2.9e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain V-set_2 PF15910.3 031674.1_45722001_1 - 0.0003 20.7 0.0 0.00038 20.4 0.0 1.2 1 0 0 1 1 1 1 ICOS V-set domain Ig_3 PF13927.4 031674.1_45722001_1 - 0.0073 16.8 0.1 0.013 16.0 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 031674.1_45722001_1 - 0.045 13.7 0.0 0.068 13.1 0.0 1.4 1 1 0 1 1 1 0 Immunoglobulin I-set domain 3HCDH_N PF02737.16 214331.1_49824001_2 - 3.6e-63 212.6 3.4 5e-63 212.1 3.4 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.20 214331.1_49824001_2 - 2.7e-34 117.5 0.0 5.1e-34 116.6 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Pyr_redox_2 PF07992.12 214331.1_49824001_2 - 6.2e-06 25.5 0.3 9.4e-06 24.9 0.3 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.25 214331.1_49824001_2 - 9.6e-05 22.7 0.3 0.00019 21.8 0.3 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.19 214331.1_49824001_2 - 0.00019 20.7 2.7 0.00027 20.1 2.7 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.12 214331.1_49824001_2 - 0.00095 18.6 0.3 0.0016 17.9 0.3 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.13 214331.1_49824001_2 - 0.00096 19.2 4.2 0.008 16.2 4.2 2.1 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase DAO PF01266.22 214331.1_49824001_2 - 0.0011 18.6 0.1 0.0017 17.9 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_Gly3P_dh_N PF01210.21 214331.1_49824001_2 - 0.0014 18.5 0.9 0.003 17.4 0.9 1.5 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.15 214331.1_49824001_2 - 0.0027 18.1 1.7 0.0081 16.6 1.7 1.9 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_7 PF13241.4 214331.1_49824001_2 - 0.012 15.9 0.7 0.02 15.2 0.7 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.17 214331.1_49824001_2 - 0.029 13.6 0.2 0.051 12.8 0.2 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.16 214331.1_49824001_2 - 0.043 14.0 0.3 0.082 13.0 0.3 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_8 PF13450.4 214331.1_49824001_2 - 0.06 13.5 0.8 0.15 12.2 0.8 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain GIDA PF01134.20 214331.1_49824001_2 - 0.08 11.9 0.6 0.12 11.4 0.6 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.5 214331.1_49824001_2 - 0.68 9.1 3.2 1 8.5 3.2 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Nrap PF03813.12 022917.4_26229001_3 - 5.8e-294 977.5 0.0 6.7e-294 977.3 0.0 1.0 1 0 0 1 1 1 1 Nrap protein Alpha-amylase_C PF02806.16 001009872.1_22426001_3 - 1.9e-23 82.6 0.0 4.4e-23 81.4 0.0 1.7 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.16 001009872.1_22426001_3 - 9.9e-18 64.2 0.0 2e-17 63.1 0.0 1.6 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.22 001009872.1_22426001_3 - 5.1e-14 52.4 0.8 2.4e-12 47.0 0.1 2.3 1 1 1 2 2 2 2 Alpha amylase, catalytic domain hDGE_amylase PF14701.4 001009872.1_22426001_3 - 0.022 13.7 0.3 0.058 12.3 0.1 1.7 2 0 0 2 2 2 0 Glycogen debranching enzyme, glucanotransferase domain adh_short PF00106.23 001236.3_26223001_1 - 1.1e-35 122.8 0.0 4.6e-27 94.6 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.4 001236.3_26223001_1 - 1.2e-27 96.9 0.0 1.2e-19 70.7 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001236.3_26223001_1 - 4.2e-08 33.2 0.1 7.1e-08 32.4 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.19 001236.3_26223001_1 - 0.00012 21.5 0.0 0.00052 19.4 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.16 001236.3_26223001_1 - 0.095 12.8 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain GDP_Man_Dehyd PF16363.3 001236.3_26223001_1 - 0.11 11.7 0.0 13 4.9 0.0 2.5 2 1 1 3 3 3 0 GDP-mannose 4,6 dehydratase Syndecan PF01034.18 001013233.1_45725001_3 - 0.051 13.4 0.6 0.087 12.6 0.6 1.2 1 0 0 1 1 1 0 Syndecan domain Adeno_E3_CR2 PF02439.13 001013233.1_45725001_3 - 0.42 10.3 2.9 0.79 9.4 2.9 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 GLTP PF08718.9 001007703.1_45724001_3 - 5.1e-41 140.3 0.1 7.1e-41 139.8 0.1 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) DUF2833 PF11090.6 001007703.1_45724001_3 - 0.077 13.2 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2833) Cluap1 PF10234.7 001014225.1_45724001_2 - 3.1e-117 390.6 13.3 4.5e-117 390.1 13.3 1.2 1 0 0 1 1 1 1 Clusterin-associated protein-1 ubiquitin PF00240.21 001014225.1_45724001_2 - 0.097 12.3 4.4 0.31 10.7 0.3 2.9 3 0 0 3 3 3 0 Ubiquitin family SseC PF04888.10 001014225.1_45724001_2 - 0.1 11.9 3.7 0.15 11.4 3.7 1.3 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Tweety PF04906.11 001014225.1_45724001_2 - 2.7 6.4 3.8 2.1 6.8 2.1 1.6 1 1 0 1 1 1 0 Tweety Sdh5 PF03937.14 001008371.1_45724001_3 - 1.8e-23 82.1 0.5 2.8e-23 81.5 0.5 1.3 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase PGC7_Stella PF15549.4 001047864.1_45722001_1 - 1.1e-35 122.8 7.4 1.5e-35 122.5 7.4 1.1 1 0 0 1 1 1 1 PGC7/Stella/Dppa3 domain SNF PF00209.16 031343.1_45725001_1 - 1.1e-237 789.7 35.5 1.3e-237 789.5 35.5 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Ku_N PF03731.13 177419.2_45726001_3 - 1.4e-67 227.6 0.5 1.4e-67 227.6 0.5 2.0 3 0 0 3 3 3 1 Ku70/Ku80 N-terminal alpha/beta domain Ku PF02735.14 177419.2_45726001_3 - 1.5e-45 155.2 0.8 3.3e-45 154.1 0.8 1.6 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_PK_bind PF08785.9 177419.2_45726001_3 - 4.3e-27 94.5 1.3 4.3e-27 94.5 1.3 2.0 2 0 0 2 2 2 1 Ku C terminal domain like Ku_C PF03730.12 177419.2_45726001_3 - 3e-18 66.1 0.5 1.1e-17 64.4 0.5 2.0 1 0 0 1 1 1 1 Ku70/Ku80 C-terminal arm DUF2682 PF10909.6 177419.2_45726001_3 - 0.16 12.3 2.5 0.22 11.9 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2682) Globin PF00042.20 021588.2_45723001_1 - 7e-21 74.7 0.3 1.1e-20 74.1 0.3 1.3 1 0 0 1 1 1 1 Globin SR-25 PF10500.7 021588.2_45723001_1 - 0.4 10.1 17.6 0.74 9.3 17.6 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Peptidase_S49_N PF08496.8 021588.2_45723001_1 - 3.1 7.8 9.7 6.8 6.6 9.7 1.6 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Lipase PF00151.17 138882.1_45724001_2 - 4.4e-114 381.2 0.0 5.5e-114 380.8 0.0 1.1 1 0 0 1 1 1 1 Lipase Abhydrolase_2 PF02230.14 138882.1_45724001_2 - 0.027 14.1 0.0 0.045 13.4 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Exo_endo_phos PF03372.21 031360.2_45724001_1 - 2.1e-09 37.5 0.0 3.9e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Zip PF02535.20 031360.2_45724001_1 - 0.13 11.3 0.5 0.21 10.7 0.5 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter EOS1 PF12326.6 031360.2_45724001_1 - 0.17 11.6 0.5 0.22 11.3 0.5 1.2 1 0 0 1 1 1 0 N-glycosylation protein Phage_holin_3_6 PF07332.9 031360.2_45724001_1 - 0.28 11.1 5.7 0.62 10.0 5.7 1.5 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III O-antigen_lig PF13425.4 031360.2_45724001_1 - 2 7.0 4.8 0.82 8.2 2.5 1.5 2 0 0 2 2 2 0 O-antigen ligase like membrane protein NPR3 PF03666.11 031360.2_45724001_2 - 2 7.0 15.1 2.4 6.7 15.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 EOS1 PF12326.6 031360.2_45724001_3 - 0.21 11.4 0.2 0.25 11.1 0.2 1.2 1 0 0 1 1 1 0 N-glycosylation protein IL8 PF00048.18 001025214.1_49821001_1 - 9.7e-19 67.2 0.1 1.3e-18 66.7 0.1 1.2 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like LNS2 PF08235.11 001014184.1_45727001_2 - 3.1e-104 347.2 0.0 4.7e-104 346.6 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.12 001014184.1_45727001_2 - 1.6e-44 149.9 0.0 3.9e-44 148.7 0.0 1.7 2 0 0 2 2 2 1 lipin, N-terminal conserved region Lipin_mid PF16876.3 001014184.1_45727001_2 - 6.3e-34 116.1 0.0 1.4e-33 115.0 0.0 1.6 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain Glyco_transf_8 PF01501.18 031043.2_45724001_2 - 2.8e-19 69.5 0.1 4.3e-17 62.4 0.1 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.6 031043.2_45724001_2 - 0.015 14.5 0.0 0.025 13.8 0.0 1.3 1 0 0 1 1 1 0 Mannosyltransferase putative RRM_1 PF00076.20 001012184.1_45724001_2 - 9.1e-33 111.8 0.0 9.7e-17 60.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001012184.1_45724001_2 - 0.028 14.4 0.0 4.5 7.3 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif PA28_beta PF02252.16 214348.1_49822001_2 - 1.8e-65 218.9 3.4 2.5e-65 218.4 3.4 1.2 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.16 214348.1_49822001_2 - 6.8e-25 86.9 2.0 1.7e-24 85.6 2.0 1.7 1 0 0 1 1 1 1 Proteasome activator pa28 alpha subunit TMF_TATA_bd PF12325.6 214348.1_49822001_2 - 0.17 12.0 1.7 0.24 11.5 0.3 1.9 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding IP_trans PF02121.16 053742.1_45726001_1 - 2.3e-117 390.8 1.4 3.1e-117 390.4 1.4 1.1 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein Pkinase PF00069.23 138833.1_45727001_3 - 2.9e-73 246.3 0.0 4.3e-73 245.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 138833.1_45727001_3 - 3.9e-40 137.6 0.0 5.5e-40 137.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 138833.1_45727001_3 - 2.8e-09 36.6 0.0 1.4e-08 34.3 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.12 138833.1_45727001_3 - 0.02 14.1 0.0 0.033 13.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Myc_N PF01056.16 001009426.1_39525001_2 - 1.6e-116 389.7 7.6 2.4e-116 389.1 7.6 1.3 1 0 0 1 1 1 1 Myc amino-terminal region Myc-LZ PF02344.13 001009426.1_39525001_2 - 8e-17 60.9 9.6 2.3e-16 59.4 9.6 1.9 1 0 0 1 1 1 1 Myc leucine zipper domain HLH PF00010.24 001009426.1_39525001_2 - 4.2e-14 52.1 1.5 4.2e-14 52.1 1.5 2.5 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain SRP-alpha_N PF04086.11 001009426.1_39525001_2 - 7.4 6.3 10.1 12 5.6 10.1 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SH3_9 PF14604.4 001005762.1_45726001_3 - 4e-43 144.9 0.6 3.2e-14 52.4 0.1 3.3 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.26 001005762.1_45726001_3 - 5.4e-38 128.2 0.1 1.4e-12 46.9 0.0 3.4 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.15 001005762.1_45726001_3 - 1.8e-28 97.8 0.6 2.9e-11 42.7 0.0 3.4 3 0 0 3 3 3 3 Variant SH3 domain Sorb PF02208.14 001005762.1_45726001_3 - 2.2e-15 55.9 0.2 5.6e-15 54.6 0.2 1.7 1 0 0 1 1 1 1 Sorbin homologous domain End3 PF12761.5 001005762.1_45726001_3 - 0.038 14.0 0.1 0.079 13.0 0.1 1.5 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 Bul1_N PF04425.10 001005762.1_45726001_3 - 0.19 10.3 0.3 0.3 9.6 0.3 1.2 1 0 0 1 1 1 0 Bul1 N terminus Peptidase_C2 PF00648.19 006615.2_26225001_3 - 1.7e-130 434.3 0.0 2.3e-130 433.8 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 006615.2_26225001_3 - 7.2e-52 175.3 0.0 1.3e-51 174.5 0.0 1.4 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_1 PF00036.30 006615.2_26225001_3 - 1.5e-11 42.8 0.7 9.3e-05 21.6 0.2 4.0 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.4 006615.2_26225001_3 - 2.8e-08 32.9 2.5 0.0018 17.9 0.0 4.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.4 006615.2_26225001_3 - 2.3e-07 30.3 4.6 4.6e-06 26.2 0.4 3.3 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.4 006615.2_26225001_3 - 0.0003 21.0 4.3 0.2 12.0 0.6 3.5 2 1 0 2 2 2 2 EF-hand domain pair Ndufs5 PF10200.7 006615.2_26225001_3 - 0.0025 17.9 0.1 0.22 11.7 0.0 3.2 3 0 0 3 3 3 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa EF-hand_5 PF13202.4 006615.2_26225001_3 - 0.018 14.4 4.4 0.74 9.3 0.1 3.2 3 0 0 3 3 3 0 EF hand CotJA PF11007.6 006615.2_26225001_3 - 0.023 14.4 0.1 13 5.6 0.0 3.2 3 0 0 3 3 3 0 Spore coat associated protein JA (CotJA) BPS PF08947.8 031623.1_45724001_1 - 1.3e-28 98.4 0.1 2.8e-28 97.3 0.1 1.6 1 0 0 1 1 1 1 BPS (Between PH and SH2) SH2 PF00017.22 031623.1_45724001_1 - 1.2e-15 57.2 0.0 2.3e-15 56.3 0.0 1.5 1 0 0 1 1 1 1 SH2 domain RA PF00788.21 031623.1_45724001_1 - 4.3e-15 56.0 0.6 1.6e-14 54.2 0.7 1.9 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain PH PF00169.27 031623.1_45724001_1 - 4.4e-12 46.3 0.1 7.1e-11 42.4 0.0 2.5 2 0 0 2 2 2 1 PH domain DUF3915 PF13054.4 031623.1_45724001_1 - 0.51 10.2 7.1 1.1 9.2 7.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF3915 PF13054.4 031623.1_45724001_2 - 0.54 10.1 6.9 1.1 9.2 6.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 031623.1_45724001_2 - 4.3 5.4 13.3 6.2 4.8 13.3 1.1 1 0 0 1 1 1 0 Atrophin-1 family Abhydrolase_1 PF00561.18 001007680.1_45725001_3 - 5.8e-24 85.0 0.2 1.2e-22 80.7 0.2 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001007680.1_45725001_3 - 4.2e-17 63.3 0.0 7e-17 62.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 001007680.1_45725001_3 - 5.8e-14 51.8 0.0 1.2e-13 50.7 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.12 001007680.1_45725001_3 - 1.9e-05 23.4 0.0 4.1e-05 22.3 0.0 1.4 1 1 0 1 1 1 1 Ndr family DUF1057 PF06342.10 001007680.1_45725001_3 - 0.0016 17.4 0.0 0.0025 16.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) FSH1 PF03959.11 001007680.1_45725001_3 - 0.0078 15.8 0.1 0.41 10.2 0.0 2.4 2 1 0 2 2 2 1 Serine hydrolase (FSH1) Lipase PF00151.17 001007680.1_45725001_3 - 0.067 12.3 0.0 0.099 11.8 0.0 1.1 1 0 0 1 1 1 0 Lipase DLH PF01738.16 001007680.1_45725001_3 - 0.1 12.0 0.0 1 8.7 0.0 2.0 2 0 0 2 2 2 0 Dienelactone hydrolase family Cyclin_N PF00134.21 012766.1_45724001_2 - 5.2e-34 116.6 0.6 7.3e-34 116.2 0.6 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 012766.1_45724001_2 - 4.7e-16 58.8 0.2 1.2e-15 57.5 0.0 1.7 2 0 0 2 2 2 1 Cyclin, C-terminal domain TNFR_c6 PF00020.16 130426.4_45726001_1 - 2.5e-21 75.7 43.0 1.2e-08 35.1 8.7 4.9 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region Mito_carr PF00153.25 145677.1_45727001_2 - 1e-71 236.8 3.0 3.7e-24 84.4 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.4 145677.1_45727001_2 - 5.2e-14 52.3 1.4 1.9e-10 40.9 0.4 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 145677.1_45727001_2 - 3.2e-12 44.9 3.2 0.004 16.5 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.4 145677.1_45727001_2 - 2.8e-10 39.2 3.4 0.00075 19.1 0.2 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.4 145677.1_45727001_2 - 1.2e-06 28.1 1.6 0.02 14.5 0.1 2.8 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 145677.1_45727001_2 - 2.4e-06 26.7 1.6 0.0049 16.2 0.1 3.2 3 0 0 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.7 145677.1_45727001_2 - 0.0055 16.9 1.4 0.011 15.9 1.4 1.4 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.4 145677.1_45727001_2 - 0.011 15.5 0.6 2.3 8.0 0.0 3.2 2 1 1 3 3 3 0 EF hand DUF2624 PF11116.6 145677.1_45727001_2 - 0.16 12.8 0.0 0.3 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2624) EF-hand_4 PF12763.5 145677.1_45727001_2 - 0.23 11.3 2.2 1 9.2 0.2 2.3 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand DEAD PF00270.27 001006996.1_45725001_1 - 3.6e-46 157.0 0.1 7.9e-46 155.9 0.1 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001006996.1_45725001_1 - 1.4e-24 86.5 0.0 1.3e-23 83.4 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.4 001006996.1_45725001_1 - 2.8e-19 68.9 0.3 5.6e-19 68.0 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.13 001006996.1_45725001_1 - 1.7e-06 28.0 0.0 3.4e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit WD40 PF00400.30 031037.2_45724001_1 - 6.9e-41 137.3 20.7 2.8e-06 27.8 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 031037.2_45724001_1 - 5.4e-16 58.5 0.0 0.00077 19.6 0.0 5.4 1 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 031037.2_45724001_1 - 4.1e-05 22.9 0.0 0.00014 21.2 0.0 1.8 1 1 1 2 2 2 1 WD40-like domain CALM_bind PF16025.3 031037.2_45724001_1 - 0.16 12.3 0.1 0.16 12.3 0.1 1.6 2 0 0 2 2 2 0 Calcium-dependent calmodulin binding 7tm_1 PF00001.19 001009410.1_39527001_2 - 8.1e-28 97.3 23.4 1.5e-27 96.4 23.4 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.4 001009410.1_39527001_2 - 9.5e-18 63.6 2.8 9.6e-05 21.9 0.3 4.6 2 2 2 4 4 4 4 Leucine rich repeat LRR_5 PF13306.4 001009410.1_39527001_2 - 1.3e-12 47.7 0.8 1.5e-06 28.0 0.2 2.4 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) PAM2 PF07145.13 001014148.1_45724001_1 - 9.8e-07 27.9 0.7 2.5e-06 26.6 0.7 1.7 1 0 0 1 1 1 1 Ataxin-2 C-terminal region Neuromodulin PF06614.9 001009816.1_39722001_1 - 2.7e-79 265.2 64.7 2.7e-79 265.2 64.7 1.7 2 0 0 2 2 2 1 Neuromodulin Neuromodulin_N PF10580.7 001009816.1_39722001_1 - 1.7e-18 65.8 6.1 1.7e-18 65.8 6.1 3.6 5 0 0 5 5 5 1 Gap junction protein N-terminal region IQ PF00612.25 001009816.1_39722001_1 - 1.1e-06 27.7 0.4 2.1e-06 26.9 0.4 1.5 1 0 0 1 1 1 1 IQ calmodulin-binding motif EMP70 PF02990.14 001005554.1_45726001_1 - 2.4e-212 706.0 13.6 2.4e-212 706.0 13.6 1.5 2 0 0 2 2 2 1 Endomembrane protein 70 3Beta_HSD PF01073.17 001009399.1_45724001_3 - 1e-61 208.2 0.0 1.4e-61 207.8 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 001009399.1_45724001_3 - 3.5e-34 118.2 0.0 4.7e-34 117.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 001009399.1_45724001_3 - 4.4e-17 62.3 0.0 2e-15 56.9 0.0 2.4 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.4 001009399.1_45724001_3 - 1.4e-15 57.6 0.0 2e-15 57.1 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.15 001009399.1_45724001_3 - 3.1e-11 42.8 0.0 4.4e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.10 001009399.1_45724001_3 - 4.1e-09 35.9 0.0 0.00014 21.0 0.0 2.4 1 1 1 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.13 001009399.1_45724001_3 - 2.6e-07 29.9 0.0 2.1e-06 27.0 0.0 2.3 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein NmrA PF05368.11 001009399.1_45724001_3 - 7.1e-05 22.3 0.0 0.00012 21.6 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_2 PF03446.13 001009399.1_45724001_3 - 0.032 14.3 0.0 0.14 12.2 0.0 1.9 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Serinc PF03348.13 182951.1_45726001_1 - 8.5e-174 578.3 16.0 1.1e-173 578.0 16.0 1.1 1 0 0 1 1 1 1 Serine incorporator (Serinc) Porin_3 PF01459.20 213960.1_49822001_1 - 2.3e-83 279.6 4.1 2.7e-83 279.4 4.1 1.0 1 0 0 1 1 1 1 Eukaryotic porin ABC_tran PF00005.25 053924.1_45729001_2 - 3.6e-52 176.4 0.1 3.3e-30 105.2 0.0 3.1 3 0 0 3 3 3 2 ABC transporter ABC_membrane PF00664.21 053924.1_45729001_2 - 5.1e-50 170.5 33.8 1.8e-33 116.2 11.3 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.17 053924.1_45729001_2 - 5.6e-10 38.9 7.3 0.016 14.5 0.0 4.3 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.4 053924.1_45729001_2 - 0.0005 19.6 2.2 0.51 10.0 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.4 053924.1_45729001_2 - 0.00075 19.9 0.7 0.32 11.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.21 053924.1_45729001_2 - 0.0022 17.9 2.1 0.98 9.4 0.2 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_21 PF13304.4 053924.1_45729001_2 - 0.0048 16.6 9.4 3.6 7.2 0.1 3.9 3 1 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system Dynamin_N PF00350.21 053924.1_45729001_2 - 0.0054 16.7 1.4 0.061 13.2 0.0 2.5 2 0 0 2 2 2 1 Dynamin family DUF258 PF03193.14 053924.1_45729001_2 - 0.0064 16.3 0.9 0.2 11.4 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_24 PF13479.4 053924.1_45729001_2 - 0.02 14.5 0.2 0.26 10.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.15 053924.1_45729001_2 - 0.062 12.9 0.0 2.7 7.6 0.0 2.7 2 0 0 2 2 2 0 IstB-like ATP binding protein Zeta_toxin PF06414.10 053924.1_45729001_2 - 0.066 12.4 0.6 2.8 7.0 0.1 2.6 3 0 0 3 3 3 0 Zeta toxin NB-ARC PF00931.20 053924.1_45729001_2 - 0.075 11.9 0.2 2.4 7.0 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain AAA_18 PF13238.4 053924.1_45729001_2 - 0.086 13.2 0.1 11 6.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain TsaE PF02367.15 053924.1_45729001_2 - 0.17 11.7 0.5 0.43 10.5 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE LVIVD PF08309.9 053924.1_45729001_2 - 0.18 11.0 0.1 0.51 9.6 0.1 1.7 1 0 0 1 1 1 0 LVIVD repeat DUF87 PF01935.15 053924.1_45729001_2 - 0.27 11.1 2.7 2.6 7.9 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF87 cobW PF02492.17 053924.1_45729001_2 - 0.31 10.5 3.2 0.21 11.0 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.4 053924.1_45729001_2 - 2.6 8.2 4.8 23 5.1 0.3 3.1 2 1 0 2 2 2 0 AAA domain Thiolase_N PF00108.21 130433.1_45724001_3 - 2.7e-92 308.7 0.1 4.6e-92 307.9 0.1 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.16 130433.1_45724001_3 - 4.4e-49 165.1 0.1 8.3e-49 164.2 0.1 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.24 130433.1_45724001_3 - 0.0048 16.4 4.3 0.016 14.7 0.3 2.8 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain Ribosomal_L21e PF01157.16 053330.1_45722001_1 - 3.5e-52 174.2 8.6 3.5e-52 174.2 8.6 1.5 2 0 0 2 2 2 1 Ribosomal protein L21e LYRIC PF15686.3 053330.1_45722001_1 - 0.022 14.2 1.3 0.027 13.9 1.3 1.1 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family CLP_protease PF00574.21 053330.1_45722001_1 - 0.099 12.4 0.1 0.15 11.7 0.1 1.2 1 0 0 1 1 1 0 Clp protease zf-CCCH PF00642.22 001004233.1_45723001_1 - 3e-16 58.8 18.9 1.4e-05 24.7 4.5 3.9 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.3 001004233.1_45723001_1 - 3.7e-15 56.4 11.0 2.5e-05 24.8 0.5 3.5 2 1 1 3 3 3 3 Torus domain zf-RING_UBOX PF13445.4 001004233.1_45723001_1 - 1.5e-06 28.0 0.1 6e-06 26.0 0.1 2.2 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001004233.1_45723001_1 - 1.7e-06 27.7 1.9 1.7e-06 27.7 1.9 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH_3 PF15663.3 001004233.1_45723001_1 - 2.6e-06 27.5 3.0 2.6e-06 27.5 3.0 2.3 2 0 0 2 2 2 1 Zinc-finger containing family zf-RING_5 PF14634.4 001004233.1_45723001_1 - 0.00032 20.5 2.0 0.00032 20.5 2.0 2.2 2 0 0 2 2 1 1 zinc-RING finger domain zf-RING_2 PF13639.4 001004233.1_45723001_1 - 0.00058 19.9 1.4 0.00058 19.9 1.4 3.5 3 1 1 4 4 3 1 Ring finger domain zf-rbx1 PF12678.5 001004233.1_45723001_1 - 0.0013 18.9 1.5 0.0013 18.9 1.5 2.9 2 1 1 3 3 3 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.4 001004233.1_45723001_1 - 0.0021 17.7 6.5 0.0048 16.6 3.0 3.2 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.5 001004233.1_45723001_1 - 0.0067 16.3 0.7 0.0067 16.3 0.7 2.8 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.4 001004233.1_45723001_1 - 0.011 15.7 0.5 0.011 15.7 0.5 3.5 4 0 0 4 4 4 0 zinc finger of C3HC4-type, RING zf-CCCH_2 PF14608.4 001004233.1_45723001_1 - 0.02 15.2 30.3 0.1 13.0 3.9 5.0 5 0 0 5 5 4 0 RNA-binding, Nab2-type zinc finger zf-RING_11 PF17123.3 001004233.1_45723001_1 - 0.026 14.1 2.1 0.11 12.1 2.1 2.2 1 0 0 1 1 1 0 RING-like zinc finger zf-H2C2_2 PF13465.4 001012030.1_45727001_2 - 9.1e-18 63.7 20.5 1.7e-06 28.1 0.2 4.9 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.24 001012030.1_45727001_2 - 4.1e-11 42.6 33.5 0.003 17.8 0.8 4.9 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001012030.1_45727001_2 - 0.0037 17.8 11.1 0.0081 16.8 3.6 5.5 5 0 0 5 5 5 4 C2H2-type zinc finger FYVE PF01363.19 001012030.1_45727001_2 - 0.059 13.4 10.8 0.3 11.1 0.0 3.0 1 1 1 2 2 2 0 FYVE zinc finger GAGA PF09237.9 001012030.1_45727001_2 - 0.88 9.3 7.7 0.23 11.1 1.6 2.8 2 1 0 2 2 2 0 GAGA factor DZR PF12773.5 001012030.1_45727001_2 - 1.3 8.9 7.2 8 6.4 2.0 2.6 2 0 0 2 2 2 0 Double zinc ribbon zf-C2H2_6 PF13912.4 001012030.1_45727001_2 - 1.4 8.9 23.0 0.15 11.9 1.3 4.7 4 1 0 4 4 4 0 C2H2-type zinc finger XPA_N PF01286.16 001012030.1_45727001_2 - 5.6 6.9 9.0 9.2 6.3 0.0 4.1 4 0 0 4 4 4 0 XPA protein N-terminal FCP1_C PF09309.8 026295.2_32928001_2 - 4.8e-125 416.6 12.7 4.8e-125 416.6 12.7 2.2 2 1 0 2 2 2 1 FCP1, C-terminal NIF PF03031.16 026295.2_32928001_2 - 1.7e-23 83.0 0.0 3.4e-23 82.0 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase PTCB-BRCT PF12738.5 026295.2_32928001_2 - 0.00012 21.8 0.0 0.00024 20.9 0.0 1.4 1 0 0 1 1 1 1 twin BRCT domain Biotin_lipoyl PF00364.20 026295.2_32928001_2 - 0.0036 17.0 0.0 0.46 10.2 0.0 2.4 2 0 0 2 2 2 1 Biotin-requiring enzyme LIG3_BRCT PF16759.3 026295.2_32928001_2 - 0.0072 16.5 0.2 0.014 15.5 0.2 1.5 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain BRCT PF00533.24 026295.2_32928001_2 - 0.013 15.8 0.0 0.027 14.7 0.0 1.5 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.3 026295.2_32928001_2 - 0.11 12.2 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain Ras PF00071.20 001013060.1_45724001_1 - 1.8e-50 170.6 0.0 2.5e-50 170.1 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001013060.1_45724001_1 - 3.3e-17 62.7 0.0 5.3e-17 62.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001013060.1_45724001_1 - 7.6e-11 41.6 0.0 1.2e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family ATP_bind_1 PF03029.15 001013060.1_45724001_1 - 0.0026 17.4 0.2 0.0077 15.9 0.1 1.6 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.25 001013060.1_45724001_1 - 0.0031 17.0 0.0 0.0044 16.4 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001013060.1_45724001_1 - 0.092 12.5 0.0 15 5.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Torsin PF06309.9 001009683.1_45724001_1 - 2.4e-57 192.4 0.2 3.6e-57 191.8 0.2 1.3 1 0 0 1 1 1 1 Torsin AAA_22 PF13401.4 001009683.1_45724001_1 - 0.00022 21.4 0.1 0.021 15.0 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA PF00004.27 001009683.1_45724001_1 - 0.02 15.2 0.0 0.034 14.4 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.10 001009683.1_45724001_1 - 0.14 11.3 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin Calcipressin PF04847.10 175578.3_45727001_1 - 3.6e-62 209.3 0.4 5.1e-62 208.8 0.4 1.2 1 0 0 1 1 1 1 Calcipressin Aa_trans PF01490.16 138832.1_45725001_3 - 1e-79 268.0 40.1 1.2e-79 267.8 40.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Cation_ATPase_C PF00689.19 138832.1_45725001_3 - 0.0026 17.4 12.9 0.0026 17.4 12.9 2.8 1 1 1 3 3 3 1 Cation transporting ATPase, C-terminus AKAP_110 PF05716.11 139289.1_26226001_2 - 1.4e-117 393.7 34.6 1.8e-65 221.4 10.9 3.3 1 1 2 3 3 3 3 A-kinase anchor protein 110 kDa (AKAP 110) RII_binding_1 PF10522.7 139289.1_26226001_2 - 2.2e-05 24.0 0.0 7.6e-05 22.4 0.0 2.0 1 0 0 1 1 1 1 RII binding domain TGFb_propeptide PF00688.16 214435.2_49823001_1 - 1.3e-31 110.1 0.0 1.8e-31 109.6 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 214435.2_49823001_1 - 1.5e-27 96.4 2.3 1.7e-27 96.2 1.0 1.8 2 0 0 2 2 2 1 Transforming growth factor beta like domain FBA PF04300.11 138917.3_45722001_1 - 6.8e-76 254.0 0.0 8.9e-76 253.6 0.0 1.1 1 0 0 1 1 1 1 F-box associated region F-box-like PF12937.5 138917.3_45722001_1 - 4.2e-09 36.0 2.2 8.8e-09 35.0 2.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 138917.3_45722001_1 - 1.1e-06 28.2 2.0 2.7e-06 27.0 2.0 1.7 1 0 0 1 1 1 1 F-box domain Lys PF00062.18 001009073.1_39721001_1 - 4.8e-57 191.4 2.3 5.4e-57 191.3 2.3 1.0 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family SLT PF01464.18 001009073.1_39721001_1 - 0.00065 19.2 0.0 0.00092 18.7 0.0 1.2 1 0 0 1 1 1 1 Transglycosylase SLT domain Destabilase PF05497.10 001009073.1_39721001_1 - 0.086 13.0 2.7 0.14 12.3 1.9 1.8 1 1 1 2 2 2 0 Destabilase Ras PF00071.20 001015023.1_45724001_1 - 5e-39 133.4 0.2 1.8e-36 125.0 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.11 001015023.1_45724001_1 - 2.5e-27 95.4 0.0 3.8e-27 94.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001015023.1_45724001_1 - 3.4e-09 36.3 0.0 1.7e-08 34.0 0.0 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001015023.1_45724001_1 - 0.059 13.3 0.0 0.092 12.7 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase MCRS_N PF13325.4 001013106.1_45724001_1 - 3.9e-94 314.1 6.3 5.3e-94 313.7 6.3 1.2 1 0 0 1 1 1 1 N-terminal region of micro-spherule protein FHA PF00498.24 001013106.1_45724001_1 - 3.2e-05 24.0 0.0 6.1e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 FHA domain zf-RING_2 PF13639.4 001011960.1_45725001_3 - 9e-09 35.3 23.6 5.1e-08 32.9 10.3 3.8 3 0 0 3 3 3 2 Ring finger domain SWIM PF04434.15 001011960.1_45725001_3 - 1e-07 31.3 0.8 2.6e-07 30.0 0.8 1.7 1 0 0 1 1 1 1 SWIM zinc finger zf-RING_11 PF17123.3 001011960.1_45725001_3 - 2.8e-06 26.8 3.9 2.8e-06 26.8 3.9 3.5 4 0 0 4 4 4 1 RING-like zinc finger ZZ PF00569.15 001011960.1_45725001_3 - 2e-05 24.2 12.8 2e-05 24.2 12.8 2.7 2 0 0 2 2 2 1 Zinc finger, ZZ type zf-C3HC4_2 PF13923.4 001011960.1_45725001_3 - 0.00015 21.4 10.6 0.00015 21.4 10.6 4.6 3 2 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001011960.1_45725001_3 - 0.00041 20.0 10.4 0.00041 20.0 10.4 3.9 3 1 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 001011960.1_45725001_3 - 0.0014 18.8 9.5 0.0014 18.8 9.5 3.9 3 1 0 3 3 3 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.5 001011960.1_45725001_3 - 0.0073 16.2 2.6 0.0073 16.2 2.6 3.7 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.4 001011960.1_45725001_3 - 3.8 7.4 42.6 0.28 11.0 3.8 4.0 3 0 0 3 3 3 0 zinc-RING finger domain Prok-RING_4 PF14447.4 001011960.1_45725001_3 - 6.9 6.5 31.3 0.66 9.7 7.9 4.9 4 1 0 4 4 4 0 Prokaryotic RING finger family 4 Osteopontin PF00865.16 214023.1_49823001_2 - 4.4e-134 446.4 52.6 5.2e-134 446.2 52.6 1.0 1 0 0 1 1 1 1 Osteopontin MRP-L28 PF09812.7 001024865.1_45725001_1 - 9.4e-62 207.8 11.0 1.3e-61 207.3 11.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 zf-HC5HC2H_2 PF13832.4 001012162.1_45729001_3 - 7.4e-30 103.2 11.6 7.4e-30 103.2 11.6 2.7 3 0 0 3 3 3 2 PHD-zinc-finger like domain zf-HC5HC2H PF13771.4 001012162.1_45729001_3 - 1.8e-21 76.0 10.6 1.8e-21 76.0 10.6 3.4 4 0 0 4 4 4 2 PHD-like zinc-binding domain PHD_2 PF13831.4 001012162.1_45729001_3 - 5.3e-13 48.1 4.2 5.3e-13 48.1 4.2 2.7 2 0 0 2 2 2 1 PHD-finger PHD PF00628.27 001012162.1_45729001_3 - 4.5e-08 32.7 9.6 4.5e-08 32.7 9.6 3.6 3 0 0 3 3 3 1 PHD-finger 7tm_1 PF00001.19 019310.1_45723001_1 - 1.8e-51 174.9 14.2 4e-51 173.7 14.2 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) JTB PF05439.10 019310.1_45723001_1 - 0.052 13.5 1.1 6.3 6.8 0.1 2.8 3 0 0 3 3 3 0 Jumping translocation breakpoint protein (JTB) DUF2542 PF10808.6 019310.1_45723001_1 - 2.5 8.5 0.0 2.5 8.5 0.0 4.3 4 1 2 6 6 6 0 Protein of unknown function (DUF2542) TrbC PF04956.11 019310.1_45723001_1 - 4.8 7.3 9.1 4.6 7.4 0.9 2.7 3 0 0 3 3 3 0 TrbC/VIRB2 family GCS PF03074.14 012815.2_45727001_1 - 1.5e-181 603.5 0.0 2e-181 603.1 0.0 1.2 1 0 0 1 1 1 1 Glutamate-cysteine ligase GCS2 PF04107.11 012815.2_45727001_1 - 0.058 12.6 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Glutamate-cysteine ligase family 2(GCS2) SRF-TF PF00319.16 001014035.1_45727001_2 - 1.3e-23 82.0 0.4 2.3e-23 81.2 0.4 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.6 001014035.1_45727001_2 - 1.4e-20 72.9 0.3 1.4e-20 72.9 0.3 2.6 2 0 0 2 2 2 1 Holliday junction regulator protein family C-terminal repeat TFIIA PF03153.11 001014035.1_45727001_2 - 0.17 11.7 8.5 0.23 11.3 8.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TPR_1 PF00515.26 001004243.1_45725001_2 - 7.6e-38 126.7 14.7 6.1e-08 32.0 0.5 6.6 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.15 001004243.1_45725001_2 - 1.1e-28 96.8 15.7 7.6e-06 25.5 0.1 6.6 6 0 0 6 6 6 6 Tetratricopeptide repeat RPAP3_C PF13877.4 001004243.1_45725001_2 - 6.7e-24 84.1 0.3 1.9e-23 82.7 0.3 1.8 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 TPR_11 PF13414.4 001004243.1_45725001_2 - 7.3e-21 73.5 7.4 4.3e-07 29.4 0.1 4.7 4 1 1 5 5 5 3 TPR repeat TPR_8 PF13181.4 001004243.1_45725001_2 - 8.3e-20 69.2 12.0 0.0042 17.1 0.3 6.9 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.4 001004243.1_45725001_2 - 4.7e-13 48.0 6.8 0.00027 20.6 0.0 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.4 001004243.1_45725001_2 - 8.2e-11 42.3 2.4 0.044 14.3 0.0 4.8 2 2 2 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.4 001004243.1_45725001_2 - 8.5e-11 41.9 7.6 0.33 11.1 0.0 5.4 3 2 1 4 4 4 4 Tetratricopeptide repeat TPR_19 PF14559.4 001004243.1_45725001_2 - 1.5e-09 38.1 2.6 0.014 15.7 0.4 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.4 001004243.1_45725001_2 - 2.2e-09 37.2 2.0 0.28 12.0 0.5 5.5 5 2 1 6 6 4 2 Tetratricopeptide repeat TPR_9 PF13371.4 001004243.1_45725001_2 - 2.5e-06 27.4 0.6 0.5 10.4 0.0 4.3 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.4 001004243.1_45725001_2 - 7e-06 25.9 9.9 0.52 10.7 0.4 6.4 6 1 0 6 6 6 1 Tetratricopeptide repeat RPN7 PF10602.7 001004243.1_45725001_2 - 0.00063 19.3 1.1 1 8.8 0.1 3.1 2 1 0 2 2 2 2 26S proteasome subunit RPN7 Fis1_TPR_C PF14853.4 001004243.1_45725001_2 - 0.00065 19.6 9.9 0.54 10.2 0.0 5.0 6 0 0 6 6 6 1 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.16 001004243.1_45725001_2 - 0.0015 18.5 7.6 0.22 11.5 0.3 3.8 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain TPR_10 PF13374.4 001004243.1_45725001_2 - 0.0029 17.3 9.1 0.81 9.5 0.4 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.4 001004243.1_45725001_2 - 0.0056 17.1 9.7 25 5.7 0.1 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat NRBF2_MIT PF17169.2 001004243.1_45725001_2 - 0.017 15.2 4.3 2.9 8.0 0.0 3.4 3 1 0 3 3 3 0 MIT domain of nuclear receptor-binding factor 2 ANAPC3 PF12895.5 001004243.1_45725001_2 - 0.033 14.3 6.3 0.79 9.8 0.3 3.0 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Stn1 PF10451.7 001004243.1_45725001_2 - 0.034 13.0 1.8 0.068 12.0 1.8 1.5 1 0 0 1 1 1 0 Telomere regulation protein Stn1 TPR_3 PF07720.10 001004243.1_45725001_2 - 0.092 12.6 2.7 5.4 7.0 0.4 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat PPR PF01535.18 001004243.1_45725001_2 - 0.099 12.8 2.2 21 5.5 0.1 3.5 3 0 0 3 3 2 0 PPR repeat TPM_phosphatase PF04536.12 001004243.1_45725001_2 - 0.11 12.6 1.0 6.6 6.8 0.1 3.2 2 1 1 3 3 3 0 TPM domain TPR_21 PF09976.7 001004243.1_45725001_2 - 1.2 8.7 10.2 0.62 9.7 0.1 3.6 1 1 2 4 4 4 0 Tetratricopeptide repeat-like domain MCM PF00493.21 001004203.3_45725001_3 - 6.5e-135 449.3 0.0 1.2e-134 448.5 0.0 1.4 1 0 0 1 1 1 1 MCM2/3/5 family MCM_OB PF17207.1 001004203.3_45725001_3 - 8.9e-36 122.4 0.9 1.7e-35 121.5 0.9 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_N PF14551.4 001004203.3_45725001_3 - 2.6e-20 72.8 2.8 6.9e-20 71.4 2.8 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.19 001004203.3_45725001_3 - 5.1e-08 32.4 0.2 1.1e-05 24.8 0.0 2.8 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.12 001004203.3_45725001_3 - 6e-07 29.4 0.0 1.4e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) MCM_bind PF09739.7 001004203.3_45725001_3 - 0.00091 17.7 0.2 0.0018 16.7 0.2 1.4 1 0 0 1 1 1 1 Mini-chromosome maintenance replisome factor AAA_3 PF07726.9 001004203.3_45725001_3 - 0.0066 16.2 0.0 0.016 15.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase_C PF13335.4 001004203.3_45725001_3 - 0.16 12.5 1.3 0.75 10.3 1.3 2.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI C-terminal Zona_pellucida PF00100.21 001009875.1_22425001_3 - 1e-50 172.8 1.5 1.6e-50 172.1 0.1 2.0 2 0 0 2 2 2 1 Zona pellucida-like domain Peptidase_M2 PF01401.16 001039456.1_22426001_2 - 1.4e-239 796.4 7.5 1.7e-239 796.1 7.5 1.0 1 0 0 1 1 1 1 Angiotensin-converting enzyme Collectrin PF16959.3 001039456.1_22426001_2 - 3.1e-76 254.2 0.2 5.3e-76 253.4 0.2 1.4 1 0 0 1 1 1 1 Renal amino acid transporter Glycophorin_A PF01102.16 001039456.1_22426001_2 - 0.0058 16.7 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 Glycophorin A FANCF PF11107.6 001039456.1_22426001_2 - 0.037 13.1 1.8 0.073 12.2 1.8 1.4 1 0 0 1 1 1 0 Fanconi anemia group F protein (FANCF) DUF1049 PF06305.9 001039456.1_22426001_2 - 0.076 12.7 0.0 0.28 10.9 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) EphA2_TM PF14575.4 001039456.1_22426001_2 - 0.11 13.2 0.0 0.25 12.0 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4407 PF14362.4 001039456.1_22426001_2 - 0.18 11.0 0.1 0.18 11.0 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) RnaseA PF00074.18 020082.2_45723001_3 - 2.7e-39 134.3 5.3 2.7e-39 134.3 5.3 1.7 2 0 0 2 2 2 1 Pancreatic ribonuclease 7tm_1 PF00001.19 024483.1_45726001_3 - 1.5e-76 257.0 6.2 2e-76 256.7 6.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 024483.1_45726001_3 - 6.3e-12 45.3 3.4 9.3e-12 44.7 3.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 024483.1_45726001_3 - 0.00034 19.9 4.0 0.0006 19.1 4.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 024483.1_45726001_3 - 0.00044 20.0 3.5 0.00044 20.0 3.5 2.4 3 0 0 3 3 3 1 Olfactory receptor RRM_1 PF00076.20 001008303.1_45723001_2 - 6.3e-29 99.5 1.2 1.9e-14 53.1 0.1 2.6 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001008303.1_45723001_2 - 1.1e-07 31.5 0.0 0.00059 19.5 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_5 PF13893.4 001008303.1_45723001_2 - 1.6e-07 30.9 0.0 0.009 15.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4523 PF15023.4 001008303.1_45723001_2 - 0.0074 16.0 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4523) p450 PF00067.20 153313.1_45724001_1 - 3.2e-146 487.6 0.0 3.7e-146 487.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Thyroglobulin_1 PF00086.16 214003.1_49823001_3 - 3.5e-17 61.7 0.9 3.5e-17 61.7 0.9 2.1 2 0 0 2 2 2 1 Thyroglobulin type-1 repeat IGFBP PF00219.16 214003.1_49823001_3 - 9.1e-11 42.1 19.1 9.1e-11 42.1 19.1 2.5 2 1 0 2 2 2 1 Insulin-like growth factor binding protein Nucleoporin_N PF08801.9 053952.1_45729001_1 - 6.3e-97 324.9 0.0 8.7e-97 324.5 0.0 1.2 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.12 053952.1_45729001_1 - 4.5e-20 71.8 10.8 7e-20 71.2 10.8 1.2 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal T2SSF PF00482.21 053952.1_45729001_1 - 2 8.2 5.8 15 5.4 1.3 3.0 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F LRR_8 PF13855.4 178144.1_45724001_1 - 1.9e-25 88.2 29.5 3.9e-13 48.8 4.9 4.1 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 178144.1_45724001_1 - 1.6e-09 37.7 21.6 0.00034 20.8 2.1 4.6 2 1 2 5 5 5 4 Leucine Rich repeats (2 copies) Ig_3 PF13927.4 178144.1_45724001_1 - 8.3e-05 23.0 0.0 0.00026 21.4 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin domain LRR_1 PF00560.31 178144.1_45724001_1 - 0.00046 20.1 24.4 5.5 7.7 0.0 7.9 7 0 0 7 7 7 2 Leucine Rich Repeat LRR_9 PF14580.4 178144.1_45724001_1 - 0.0013 18.1 0.6 0.031 13.7 0.2 2.3 1 1 2 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.4 178144.1_45724001_1 - 0.0098 15.8 16.1 0.55 10.3 0.1 6.3 6 0 0 6 6 6 1 Leucine Rich repeat Prominin PF05478.9 178144.1_45724001_1 - 0.022 12.6 3.1 0.031 12.1 3.1 1.1 1 0 0 1 1 1 0 Prominin ig PF00047.23 178144.1_45724001_1 - 0.03 14.3 0.0 0.071 13.1 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain LRR_5 PF13306.4 178144.1_45724001_1 - 0.16 11.8 0.0 0.34 10.7 0.0 1.4 2 0 0 2 2 2 0 Leucine rich repeats (6 copies) HTH_28 PF13518.4 178144.1_45724001_1 - 0.17 11.9 0.1 1.5 8.9 0.0 2.6 4 0 0 4 4 4 0 Helix-turn-helix domain 7tm_2 PF00002.22 001012164.1_45727001_3 - 1.8e-65 220.5 19.1 2.7e-65 220.0 19.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) EGF_CA PF07645.13 001012164.1_45727001_3 - 6.2e-35 119.0 43.3 5.9e-14 51.9 6.1 4.6 4 0 0 4 4 4 3 Calcium-binding EGF domain cEGF PF12662.5 001012164.1_45727001_3 - 1.7e-13 50.1 19.1 0.00034 20.3 0.7 5.2 4 0 0 4 4 4 4 Complement Clr-like EGF-like GPS PF01825.19 001012164.1_45727001_3 - 4.4e-11 43.1 6.3 4.4e-11 43.1 6.3 3.4 4 1 0 4 4 1 1 GPCR proteolysis site, GPS, motif EGF_3 PF12947.5 001012164.1_45727001_3 - 5.2e-11 42.4 45.6 9.5e-07 28.8 1.9 5.2 5 0 0 5 5 5 3 EGF domain hEGF PF12661.5 001012164.1_45727001_3 - 0.0001 22.7 3.2 0.0001 22.7 3.2 6.6 7 0 0 7 7 5 3 Human growth factor-like EGF EGF PF00008.25 001012164.1_45727001_3 - 0.00027 21.0 6.3 0.00027 21.0 6.3 5.5 5 0 0 5 5 4 3 EGF-like domain Dicty_CAR PF05462.9 001012164.1_45727001_3 - 0.00048 19.2 16.3 0.00079 18.5 16.3 1.2 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor FXa_inhibition PF14670.4 001012164.1_45727001_3 - 0.0016 18.5 3.4 0.0016 18.5 3.4 5.2 4 1 1 5 5 4 3 Coagulation Factor Xa inhibitory site EGF_MSP1_1 PF12946.5 001012164.1_45727001_3 - 0.0026 17.6 2.4 0.0026 17.6 2.4 5.3 5 0 0 5 5 5 3 MSP1 EGF domain 1 GAIN PF16489.3 001012164.1_45727001_3 - 0.0036 16.6 2.1 0.0064 15.8 2.1 1.3 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Plasmod_Pvs28 PF06247.9 001012164.1_45727001_3 - 0.62 10.3 36.4 0.57 10.4 6.7 4.9 4 0 0 4 4 4 0 Pvs28 EGF domain Rpr2 PF04032.14 001002831.1_45721001_2 - 1.2e-25 89.6 7.2 1.6e-25 89.1 7.2 1.2 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain CNDH2_C PF16858.3 001024877.1_45725001_1 - 9e-90 301.2 0.5 9e-90 301.2 0.5 1.8 2 0 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term CNDH2_N PF06278.9 001024877.1_45725001_1 - 5.9e-29 100.4 0.0 5.9e-29 100.4 0.0 2.2 2 0 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal CNDH2_M PF16869.3 001024877.1_45725001_1 - 9.3e-20 71.7 0.9 2.2e-19 70.5 0.9 1.7 1 0 0 1 1 1 1 PF16858 CNDH2_N PF06278.9 001024877.1_45725001_2 - 1.4e-08 34.7 0.0 1.4e-08 34.7 0.0 2.0 2 0 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal SH2 PF00017.22 013135.1_45727001_1 - 1.5e-43 146.6 0.1 9.2e-21 73.6 0.0 2.6 2 0 0 2 2 2 2 SH2 domain RasGAP PF00616.17 013135.1_45727001_1 - 2.2e-26 92.7 2.0 1.6e-18 67.0 0.3 2.4 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase PH PF00169.27 013135.1_45727001_1 - 2.1e-17 63.4 0.4 1.1e-16 61.1 0.0 2.5 3 0 0 3 3 3 1 PH domain C2 PF00168.28 013135.1_45727001_1 - 4e-12 46.2 0.0 7.7e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 C2 domain SH3_1 PF00018.26 013135.1_45727001_1 - 3.3e-10 39.3 0.0 9.5e-10 37.8 0.0 1.9 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 013135.1_45727001_1 - 3.4e-05 23.5 0.1 9e-05 22.1 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH2_2 PF14633.4 013135.1_45727001_1 - 4.2e-05 22.9 0.0 0.0022 17.3 0.0 2.4 2 0 0 2 2 2 1 SH2 domain SH3_2 PF07653.15 013135.1_45727001_1 - 0.0017 17.8 0.0 0.0039 16.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.4 013135.1_45727001_1 - 0.0036 17.6 0.2 0.044 14.1 0.2 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain zf-U1 PF06220.10 013135.1_45727001_1 - 0.038 13.6 0.1 7.1 6.4 0.0 2.5 2 0 0 2 2 2 0 U1 zinc finger ABC1 PF03109.14 001012065.1_45725001_2 - 2.1e-32 111.6 0.0 3.3e-32 111.0 0.0 1.3 1 0 0 1 1 1 1 ABC1 family 7tm_1 PF00001.19 017254.1_45724001_3 - 1e-68 231.3 14.0 1.4e-68 230.9 14.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 017254.1_45724001_3 - 3e-15 56.2 18.3 4.5e-15 55.6 18.3 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 017254.1_45724001_3 - 2e-07 30.9 7.8 2e-07 30.9 7.8 2.0 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 017254.1_45724001_3 - 0.00017 20.8 16.6 0.00017 20.8 16.6 2.8 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx ATP-synt PF00231.17 053825.2_45723001_3 - 5.3e-80 269.0 5.9 6.5e-80 268.7 5.9 1.1 1 0 0 1 1 1 1 ATP synthase Syndecan PF01034.18 214284.1_49822001_2 - 1.4e-24 85.7 0.3 2.2e-24 85.0 0.3 1.3 1 0 0 1 1 1 1 Syndecan domain Abhydrolase_1 PF00561.18 212524.1_45723001_2 - 3.3e-20 72.7 0.0 6.8e-20 71.7 0.0 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 212524.1_45723001_2 - 4.4e-18 66.6 0.2 6.1e-18 66.1 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 212524.1_45723001_2 - 6.6e-11 41.8 0.0 9.5e-11 41.3 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.12 212524.1_45723001_2 - 0.0009 17.9 0.0 0.0033 16.0 0.0 1.7 2 0 0 2 2 2 1 Ndr family DUF1071 PF06378.9 212524.1_45723001_2 - 0.076 12.4 0.0 0.19 11.1 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1071) DUF2251 PF10008.7 212524.1_45723001_2 - 0.11 12.4 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2251) Polysacc_deac_1 PF01522.19 057124.2_45726001_1 - 0.082 12.7 0.3 0.2 11.4 0.3 1.6 1 0 0 1 1 1 0 Polysaccharide deacetylase OAD_gamma PF04277.11 057124.2_45726001_1 - 4.4 7.8 5.5 7.2 7.1 5.5 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain 7tm_1 PF00001.19 057124.2_45726001_3 - 1.3e-42 145.7 8.6 5.8e-42 143.6 7.1 2.2 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 057124.2_45726001_3 - 0.0046 16.2 0.0 0.0046 16.2 0.0 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv PUCC PF03209.13 057124.2_45726001_3 - 0.064 12.1 0.6 0.31 9.8 0.1 1.9 2 0 0 2 2 2 0 PUCC protein Abhydrolase_9_N PF15420.4 057124.2_45726001_3 - 0.2 11.5 3.4 0.36 10.6 3.4 1.3 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus 7tm_1 PF00001.19 013148.1_45724001_1 - 7.6e-69 231.8 10.9 1.2e-68 231.1 10.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 013148.1_45724001_1 - 0.002 17.4 2.1 0.0061 15.8 2.1 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.7 013148.1_45724001_1 - 0.014 14.6 2.8 0.033 13.4 2.8 1.5 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx DUF2208 PF09973.7 013148.1_45724001_1 - 0.064 12.7 0.2 0.064 12.7 0.2 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) Trypsin PF00089.24 213918.1_49824001_1 - 1e-68 231.4 0.0 1.3e-68 231.0 0.0 1.1 1 0 0 1 1 1 1 Trypsin Gla PF00594.18 213918.1_49824001_1 - 2e-19 69.4 6.7 4.4e-19 68.3 6.7 1.6 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FXa_inhibition PF14670.4 213918.1_49824001_1 - 1e-11 44.8 24.7 1.1e-10 41.4 10.5 3.0 2 0 0 2 2 2 2 Coagulation Factor Xa inhibitory site EGF PF00008.25 213918.1_49824001_1 - 2.6e-07 30.7 24.0 4.8e-05 23.4 10.8 2.7 2 0 0 2 2 2 2 EGF-like domain Trypsin_2 PF13365.4 213918.1_49824001_1 - 4.1e-06 27.6 0.0 6.6e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 213918.1_49824001_1 - 2.4e-05 24.5 0.0 7.6e-05 22.9 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) hEGF PF12661.5 213918.1_49824001_1 - 2.7e-05 24.5 19.6 0.00016 22.1 7.3 3.3 2 0 0 2 2 2 2 Human growth factor-like EGF EGF_2 PF07974.11 213918.1_49824001_1 - 0.032 14.5 13.7 0.032 14.5 13.7 3.1 2 0 0 2 2 2 0 EGF-like domain cEGF PF12662.5 213918.1_49824001_1 - 0.037 13.8 1.2 0.037 13.8 1.2 2.8 2 0 0 2 2 2 0 Complement Clr-like EGF-like EGF_CA PF07645.13 213918.1_49824001_1 - 0.25 11.5 30.7 1.4 9.0 12.0 3.6 2 1 1 3 3 3 0 Calcium-binding EGF domain zf-RING_2 PF13639.4 194463.1_26226001_2 - 7.3e-12 45.2 7.5 2.4e-11 43.6 7.5 2.0 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.3 194463.1_26226001_2 - 1.4e-07 30.9 3.1 4.1e-07 29.5 3.1 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.4 194463.1_26226001_2 - 2e-07 30.6 7.6 5.1e-07 29.3 7.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 194463.1_26226001_2 - 7.3e-07 29.3 6.5 7.3e-07 29.3 6.5 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.23 194463.1_26226001_2 - 1.2e-06 28.1 7.3 2.7e-06 27.0 7.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 194463.1_26226001_2 - 8.9e-06 25.5 8.2 2.6e-05 23.9 8.2 1.9 1 0 0 1 1 1 1 zinc-RING finger domain PA PF02225.20 194463.1_26226001_2 - 3.3e-05 23.8 0.0 5.9e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 PA domain zf-RING_UBOX PF13445.4 194463.1_26226001_2 - 8e-05 22.4 4.7 0.00018 21.3 4.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 194463.1_26226001_2 - 0.0033 17.1 6.5 0.0079 15.9 6.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 194463.1_26226001_2 - 0.0089 15.7 8.0 0.025 14.3 8.0 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.5 194463.1_26226001_2 - 0.024 14.5 3.8 0.058 13.3 3.8 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger PHD PF00628.27 194463.1_26226001_2 - 0.32 10.8 8.0 0.71 9.7 8.0 1.6 1 0 0 1 1 1 0 PHD-finger zf-C3H2C3 PF17122.3 194463.1_26226001_2 - 0.79 9.7 8.3 0.073 13.0 3.3 2.0 2 0 0 2 2 2 0 Zinc-finger CcmD PF04995.12 194463.1_26226001_2 - 1 9.4 3.4 0.54 10.3 0.3 2.2 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) EF-hand_7 PF13499.4 024139.2_45726001_1 - 1.9e-15 57.0 3.0 5e-11 42.8 0.9 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 024139.2_45726001_1 - 9.2e-14 50.0 1.8 4.8e-06 25.9 0.3 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.30 024139.2_45726001_1 - 1.1e-13 49.5 2.8 1.4e-05 24.1 0.4 3.4 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.4 024139.2_45726001_1 - 3.8e-06 26.4 1.8 0.00012 21.6 0.4 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.4 024139.2_45726001_1 - 5.2e-05 22.4 4.2 0.074 12.5 0.2 3.4 3 0 0 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.7 024139.2_45726001_1 - 0.0014 18.8 0.0 0.054 13.7 0.0 2.3 1 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region RST PF12174.6 024139.2_45726001_1 - 0.0088 15.9 1.1 0.054 13.3 0.0 2.6 3 0 0 3 3 3 1 RCD1-SRO-TAF4 (RST) plant domain Thioredoxin PF00085.18 001004092.2_45721001_3 - 1.8e-23 82.3 0.2 3.1e-23 81.6 0.1 1.4 2 0 0 2 2 2 1 Thioredoxin OST3_OST6 PF04756.11 001004092.2_45721001_3 - 8.9e-06 25.1 0.1 1e-05 25.0 0.1 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_9 PF14595.4 001004092.2_45721001_3 - 9.1e-05 22.1 0.1 0.00016 21.4 0.1 1.4 1 1 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.19 001004092.2_45721001_3 - 0.00057 19.7 0.1 0.00077 19.2 0.1 1.3 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.4 001004092.2_45721001_3 - 0.00086 19.5 0.1 0.0016 18.6 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_7 PF13899.4 001004092.2_45721001_3 - 0.0038 17.2 1.4 0.0054 16.7 0.4 1.7 2 1 0 2 2 2 1 Thioredoxin-like Glutaredoxin PF00462.22 001004092.2_45721001_3 - 0.029 14.4 0.1 0.11 12.6 0.1 1.9 2 0 0 2 2 2 0 Glutaredoxin Thioredoxin_2 PF13098.4 001004092.2_45721001_3 - 0.066 13.5 0.1 0.34 11.2 0.1 2.0 1 1 0 1 1 1 0 Thioredoxin-like domain Abi_HHR PF07815.12 001013118.1_45724001_3 - 9.9e-28 96.0 0.0 1.8e-27 95.1 0.0 1.4 1 0 0 1 1 1 1 Abl-interactor HHR SH3_9 PF14604.4 001013118.1_45724001_3 - 1.8e-12 46.8 0.4 4.2e-12 45.6 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 001013118.1_45724001_3 - 1.2e-09 37.5 0.0 2e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 001013118.1_45724001_3 - 2.1e-08 33.6 0.1 3.8e-08 32.8 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain E1-E2_ATPase PF00122.18 001009216.1_22428001_1 - 2.8e-64 216.3 1.3 2.8e-64 216.3 1.3 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 001009216.1_22428001_1 - 2.5e-46 157.6 2.1 5.7e-46 156.4 2.1 1.7 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 001009216.1_22428001_1 - 4.8e-21 74.5 0.5 8.7e-21 73.7 0.5 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 001009216.1_22428001_1 - 1.3e-17 64.6 0.0 1.6e-16 61.1 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 001009216.1_22428001_1 - 1.8e-16 59.4 0.8 1e-15 57.0 0.1 2.5 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 001009216.1_22428001_1 - 2e-05 24.3 0.5 4.2e-05 23.3 0.5 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 001009216.1_22428001_1 - 0.00035 20.9 0.0 0.0014 18.9 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase 7tm_4 PF13853.4 001005329.1_26222001_1 - 1.7e-116 388.7 23.5 2.1e-116 388.4 23.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001005329.1_26222001_1 - 7.4e-22 77.7 18.5 1.4e-21 76.8 18.5 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001005329.1_26222001_1 - 9.4e-09 34.9 18.9 1.4e-08 34.3 18.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx FIBP PF05427.9 172334.2_45723001_2 - 3.7e-168 559.3 0.9 4.3e-168 559.1 0.9 1.0 1 0 0 1 1 1 1 Acidic fibroblast growth factor binding (FIBP) Calponin PF00402.16 213878.1_49823001_3 - 8.7e-43 143.4 21.2 1.8e-15 56.1 2.4 3.4 3 0 0 3 3 3 3 Calponin family repeat CH PF00307.29 213878.1_49823001_3 - 3.6e-24 84.9 0.1 5.4e-24 84.4 0.1 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain CDC24 PF06395.9 213878.1_49823001_3 - 0.081 13.1 0.1 0.14 12.3 0.1 1.3 1 0 0 1 1 1 0 CDC24 Calponin CAMSAP_CH PF11971.6 213878.1_49823001_3 - 0.11 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 CAMSAP CH domain HSP20 PF00011.19 214255.2_49822001_1 - 2.1e-05 24.5 0.0 3.3e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family DUF2654 PF10849.6 214255.2_49822001_1 - 0.37 10.9 2.2 2 8.5 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2654) Ank_2 PF12796.5 001008347.1_45723001_3 - 2.6e-35 120.7 0.0 9.5e-18 64.4 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001008347.1_45723001_3 - 1.7e-34 117.6 3.8 1.6e-09 38.0 0.0 5.2 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.28 001008347.1_45723001_3 - 7.2e-34 114.6 0.1 2.4e-06 27.6 0.0 5.4 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.4 001008347.1_45723001_3 - 4.7e-33 112.6 1.5 1.9e-10 40.7 0.0 4.4 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 001008347.1_45723001_3 - 9.2e-27 90.0 0.1 0.00017 21.6 0.0 5.9 6 0 0 6 6 6 5 Ankyrin repeat Pur_ac_phosph_N PF16656.3 001008347.1_45723001_3 - 0.036 14.5 0.2 0.063 13.7 0.2 1.4 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain fn3 PF00041.19 001008347.1_45723001_3 - 0.073 13.3 0.2 0.17 12.1 0.2 1.7 1 1 0 1 1 1 0 Fibronectin type III domain Ras PF00071.20 001008320.1_45724001_1 - 2e-47 160.6 0.0 2.6e-47 160.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001008320.1_45724001_1 - 3.3e-18 65.9 0.0 4.8e-18 65.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001008320.1_45724001_1 - 0.00034 20.0 0.0 0.00053 19.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family 7tm_1 PF00001.19 053313.1_45724001_3 - 1.3e-35 122.8 30.3 5.5e-35 120.8 29.1 2.2 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 053313.1_45724001_3 - 0.054 12.7 24.7 0.098 11.9 24.7 1.4 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx Baculo_11_kDa PF06143.9 053313.1_45724001_3 - 0.46 10.0 2.3 0.64 9.5 0.1 2.3 2 0 0 2 2 2 0 Baculovirus 11 kDa family IRK PF01007.18 017296.1_45723001_1 - 4.2e-156 518.8 1.8 5.2e-156 518.5 1.8 1.0 1 0 0 1 1 1 1 Inward rectifier potassium channel IRK_N PF08466.8 017296.1_45723001_1 - 1.6e-26 92.1 1.3 3.2e-26 91.1 1.3 1.6 1 0 0 1 1 1 1 Inward rectifier potassium channel N-terminal Ion_trans_2 PF07885.14 017296.1_45723001_1 - 7.9e-05 22.4 5.5 0.00017 21.3 5.5 1.6 1 0 0 1 1 1 1 Ion channel Ion_trans PF00520.29 017296.1_45723001_1 - 0.019 14.1 4.8 0.027 13.6 4.8 1.2 1 0 0 1 1 1 0 Ion transport protein HLH PF00010.24 021700.1_45723001_3 - 1.6e-15 56.6 0.1 2.8e-15 55.9 0.1 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Skp1 PF01466.17 001007608.2_45723001_3 - 3.5e-30 103.7 1.9 6e-30 103.0 1.9 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.13 001007608.2_45723001_3 - 2.3e-29 101.2 0.2 4.8e-29 100.2 0.2 1.5 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain 7tm_1 PF00001.19 214273.1_49823001_1 - 1.6e-40 138.9 11.4 1.6e-40 138.9 11.4 1.5 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) PgaD PF13994.4 214273.1_49823001_1 - 1 9.2 4.8 11 5.8 0.1 2.6 3 0 0 3 3 3 0 PgaD-like protein Pkinase_Tyr PF07714.15 012874.1_45729001_3 - 1.3e-94 316.2 0.0 2e-94 315.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase fn3 PF00041.19 012874.1_45729001_3 - 1.8e-46 156.3 32.0 3.7e-09 36.7 0.1 9.7 9 0 0 9 9 9 8 Fibronectin type III domain Pkinase PF00069.23 012874.1_45729001_3 - 2.1e-38 132.1 0.0 3.7e-38 131.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pur_ac_phosph_N PF16656.3 012874.1_45729001_3 - 7.3e-05 23.1 5.4 2.9 8.4 0.2 6.3 6 0 0 6 6 6 2 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 012874.1_45729001_3 - 0.0078 16.4 2.9 2.7 8.2 0.1 3.9 4 0 0 4 4 4 2 Interferon-alpha/beta receptor, fibronectin type III Alpha-amylase_C PF02806.16 001010970.1_45724001_2 - 1.9e-16 60.1 0.2 5e-16 58.8 0.2 1.8 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.22 001010970.1_45724001_2 - 1.2e-13 51.2 0.0 2e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain LSR PF05624.12 001010970.1_45724001_2 - 0.024 14.5 0.0 0.045 13.6 0.0 1.4 1 0 0 1 1 1 0 Lipolysis stimulated receptor (LSR) Lectin_C PF00059.19 001007194.3_49822001_1 - 1e-17 64.7 0.4 2.1e-17 63.7 0.0 1.7 2 0 0 2 2 2 1 Lectin C-type domain Collagen PF01391.16 001007194.3_49822001_1 - 8.8e-08 31.7 29.1 1.6e-07 30.9 29.1 1.4 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) DUF2271 PF10029.7 001007194.3_49822001_3 - 2.3 7.7 6.2 3.4 7.2 6.2 1.1 1 0 0 1 1 1 0 Predicted periplasmic protein (DUF2271) Ras PF00071.20 153317.1_45722001_1 - 2.3e-67 225.5 0.5 2.9e-67 225.2 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 153317.1_45722001_1 - 4.5e-35 120.3 0.1 7.5e-35 119.6 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 153317.1_45722001_1 - 3e-17 62.5 0.2 4e-17 62.1 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 153317.1_45722001_1 - 5.6e-06 25.7 0.3 7e-06 25.4 0.3 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 153317.1_45722001_1 - 9.4e-05 21.8 0.1 0.00013 21.4 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit DUF258 PF03193.14 153317.1_45722001_1 - 0.00011 22.0 0.0 0.48 10.2 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 153317.1_45722001_1 - 0.00027 20.4 0.3 0.00059 19.3 0.1 1.6 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 153317.1_45722001_1 - 0.0003 20.7 0.0 0.00047 20.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF3963 PF13124.4 153317.1_45722001_1 - 0.026 14.4 0.8 0.052 13.4 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3963) Septin PF00735.16 153317.1_45722001_1 - 0.039 13.0 0.0 0.11 11.6 0.0 1.7 1 0 0 1 1 1 0 Septin NACHT PF05729.10 153317.1_45722001_1 - 0.043 13.6 0.0 0.58 9.9 0.0 2.2 2 0 0 2 2 2 0 NACHT domain PduV-EutP PF10662.7 153317.1_45722001_1 - 0.11 12.1 0.0 0.25 11.0 0.0 1.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.4 153317.1_45722001_1 - 0.12 12.6 0.0 0.15 12.3 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain SSF PF00474.15 001009404.1_39525001_3 - 4.3e-171 569.1 24.9 4.3e-171 569.1 24.9 2.1 2 0 0 2 2 2 1 Sodium:solute symporter family TadF PF16964.3 001009404.1_39525001_3 - 0.0041 16.8 0.0 0.0041 16.8 0.0 1.6 2 0 0 2 2 2 1 Putative tight adherence pilin protein F CUB PF00431.18 001009404.1_39525001_3 - 0.13 12.5 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 CUB domain PDZ PF00595.22 053514.1_45722001_1 - 8e-21 74.1 0.4 1.4e-20 73.3 0.4 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) L27 PF02828.14 053514.1_45722001_1 - 4.2e-12 45.5 0.1 1e-11 44.3 0.0 1.7 2 0 0 2 2 2 1 L27 domain PDZ_2 PF13180.4 053514.1_45722001_1 - 0.00056 20.0 0.0 0.0012 19.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Biopterin_H PF00351.19 173839.2_45726001_1 - 4.3e-174 578.1 0.1 5.2e-174 577.8 0.1 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.23 173839.2_45726001_1 - 7.8e-06 25.4 0.1 2.1e-05 24.1 0.0 1.7 2 0 0 2 2 2 1 ACT domain Carb_anhydrase PF00194.19 019291.1_45723001_3 - 1.1e-95 319.9 0.0 1.3e-95 319.7 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase SGL PF08450.10 031546.1_45724001_3 - 1.3e-75 254.0 0.1 1.7e-75 253.7 0.1 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region NHL PF01436.19 031546.1_45724001_3 - 0.1 12.5 0.0 0.26 11.3 0.0 1.8 1 0 0 1 1 1 0 NHL repeat E1-E2_ATPase PF00122.18 001009360.1_39528001_1 - 9.9e-58 194.9 1.9 9.9e-58 194.9 1.9 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 001009360.1_39528001_1 - 5.8e-44 149.8 0.5 5.8e-44 149.8 0.5 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 001009360.1_39528001_1 - 4e-23 81.2 0.0 8.5e-23 80.1 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 001009360.1_39528001_1 - 2.9e-19 70.1 0.0 2.5e-10 40.8 0.0 2.7 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 001009360.1_39528001_1 - 9.2e-18 63.6 0.0 1.7e-17 62.7 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 001009360.1_39528001_1 - 1e-05 25.3 1.2 0.00094 18.9 0.5 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF4455 PF14643.4 001009360.1_39528001_1 - 0.41 9.2 1.4 1.3 7.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4455) YuiB PF14068.4 001009360.1_39528001_1 - 2.6 8.6 7.6 1.2 9.6 1.2 2.9 3 0 0 3 3 3 0 Putative membrane protein BTG PF07742.10 001013176.1_45723001_1 - 1.6e-40 137.5 0.1 2.2e-40 137.0 0.1 1.2 1 0 0 1 1 1 1 BTG family Gon7 PF08738.8 001013176.1_45723001_2 - 1.7 8.6 5.8 3 7.9 5.8 1.3 1 0 0 1 1 1 0 Gon7 family JAB PF01398.19 198751.2_45723001_2 - 1e-23 83.4 0.6 1e-23 83.4 0.6 2.1 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Pou PF00157.15 214163.1_49824001_1 - 2.5e-35 120.2 0.8 8e-34 115.4 0.3 2.3 2 0 0 2 2 2 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 214163.1_49824001_1 - 2.1e-17 62.6 3.0 4.1e-17 61.6 3.0 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 214163.1_49824001_1 - 0.059 13.2 0.1 0.15 11.9 0.1 1.7 1 0 0 1 1 1 0 Homeobox KN domain Lsr2 PF11774.6 214163.1_49824001_1 - 0.16 12.0 0.4 0.29 11.1 0.4 1.4 1 0 0 1 1 1 0 Lsr2 PDZ PF00595.22 053621.1_45729001_1 - 2e-68 226.6 9.7 4e-15 55.8 0.0 6.5 6 0 0 6 6 6 6 PDZ domain (Also known as DHR or GLGF) MAGI_u1 PF16663.3 053621.1_45729001_1 - 4e-27 93.8 2.9 4e-27 93.8 2.9 2.0 2 0 0 2 2 2 1 Unstructured region on MAGI PDZ_2 PF13180.4 053621.1_45729001_1 - 7e-26 90.2 0.2 4.8e-05 23.4 0.0 5.6 6 0 0 6 6 6 5 PDZ domain WW PF00397.24 053621.1_45729001_1 - 2.7e-15 55.9 10.0 9.8e-10 38.1 0.3 3.6 4 0 0 4 4 4 2 WW domain MAGI_u5 PF16666.3 053621.1_45729001_1 - 3.8e-13 49.7 6.2 3.8e-13 49.7 6.2 6.2 6 1 0 6 6 6 1 Unstructured region on MAGI Guanylate_kin PF00625.19 053621.1_45729001_1 - 4e-10 39.5 0.0 7.2e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase Tricorn_PDZ PF14685.4 053621.1_45729001_1 - 1.6e-05 24.7 3.3 2.2 8.2 0.0 4.9 5 0 0 5 5 5 2 Tricorn protease PDZ domain Pkinase PF00069.23 001004132.1_45724001_2 - 4.9e-71 239.0 0.0 9e-71 238.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001004132.1_45724001_2 - 1.8e-34 119.1 0.0 2.6e-34 118.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001004132.1_45724001_2 - 4.4e-06 26.1 0.0 6.3e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 001004132.1_45724001_2 - 0.0018 17.5 0.3 0.0038 16.5 0.3 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.9 001004132.1_45724001_2 - 0.049 12.5 0.1 0.15 11.0 0.0 1.7 2 0 0 2 2 2 0 Seadornavirus VP7 APH PF01636.21 001004132.1_45724001_2 - 0.076 12.8 0.1 0.13 12.0 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family CPCFC PF17223.1 001004132.1_45724001_2 - 0.086 12.5 2.8 0.22 11.2 2.8 1.7 1 0 0 1 1 1 0 Cuticle protein CPCFC ATP1G1_PLM_MAT8 PF02038.14 001004132.1_45724001_3 - 0.23 10.7 1.7 15 4.9 0.1 2.4 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family Fibrinogen_C PF00147.16 001025065.1_45724001_2 - 2.8e-17 63.2 0.0 4.1e-17 62.6 0.0 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain HrpB2 PF09487.8 001025065.1_45724001_2 - 0.13 12.6 5.3 0.53 10.6 0.6 2.2 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB2) Reo_sigmaC PF04582.10 001025065.1_45724001_2 - 0.16 11.2 2.1 0.16 11.2 0.7 1.6 2 0 0 2 2 2 0 Reovirus sigma C capsid protein DUF1465 PF07323.10 001025065.1_45724001_2 - 0.17 11.6 6.1 0.19 11.4 5.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1465) DUF1664 PF07889.10 001025065.1_45724001_2 - 0.41 10.5 9.9 0.13 12.1 1.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Spc7 PF08317.9 001025065.1_45724001_2 - 0.6 8.8 18.1 1.3 7.7 17.7 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF3450 PF11932.6 001025065.1_45724001_2 - 1 8.5 14.4 0.084 12.0 2.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Sec34 PF04136.13 001025065.1_45724001_2 - 1.4 8.6 15.5 3.6 7.3 7.1 2.7 2 1 0 2 2 2 0 Sec34-like family CALCOCO1 PF07888.9 001025065.1_45724001_2 - 1.9 6.8 17.1 5 5.4 17.1 1.4 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like IncA PF04156.12 001025065.1_45724001_2 - 3.3 7.3 24.7 11 5.6 23.8 2.0 1 1 1 2 2 2 0 IncA protein SlyX PF04102.10 001025065.1_45724001_2 - 5.5 7.6 16.8 0.94 10.0 5.0 3.1 1 1 2 3 3 3 0 SlyX USP8_interact PF08941.8 001025065.1_45724001_2 - 6 6.5 10.2 1.3 8.6 1.3 2.2 2 0 0 2 2 2 0 USP8 interacting Jnk-SapK_ap_N PF09744.7 001025065.1_45724001_2 - 8.4 6.5 23.3 5.5 7.1 10.6 2.4 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Sec3_C_2 PF15278.4 001025065.1_45724001_2 - 9.1 6.6 7.6 1.6 9.0 0.8 2.5 2 0 0 2 2 2 0 Sec3 exocyst complex subunit DUF2203 PF09969.7 001025065.1_45724001_2 - 9.9 6.8 8.7 1.5e+02 3.0 8.7 2.2 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Shisa PF13908.4 001007538.1_26226001_2 - 7.5e-57 192.5 5.2 1.2e-56 191.9 5.2 1.3 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator IncA PF04156.12 001007538.1_26226001_2 - 0.2 11.3 0.2 0.33 10.6 0.2 1.3 1 0 0 1 1 1 0 IncA protein IL8 PF00048.18 030845.1_45722001_1 - 8.8e-15 54.5 0.4 1.5e-14 53.7 0.4 1.4 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like CTNNBL PF08216.9 001024870.1_45724001_2 - 9.2e-41 138.1 0.8 9.2e-41 138.1 0.8 2.0 2 0 0 2 2 2 1 Catenin-beta-like, Arm-motif containing nuclear Arm PF00514.21 001024870.1_45724001_2 - 0.014 15.3 6.4 6.5 6.8 0.1 4.0 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat DUF4604 PF15377.4 001024870.1_45724001_2 - 0.25 11.6 20.6 0.056 13.8 8.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) SAGA-Tad1 PF12767.5 001024870.1_45724001_2 - 0.38 10.3 6.7 0.11 12.1 0.4 2.5 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit AA_permease_2 PF13520.4 053929.1_45724001_2 - 1.4e-62 211.8 49.0 1.9e-62 211.4 49.0 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.19 053929.1_45724001_2 - 4.5e-24 84.7 45.6 6.4e-24 84.3 45.6 1.1 1 0 0 1 1 1 1 Amino acid permease Neur_chan_LBD PF02931.21 017194.1_45724001_3 - 2.6e-65 219.8 0.0 3.7e-65 219.3 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 017194.1_45724001_3 - 6.7e-56 189.9 0.0 1.3e-55 189.0 0.0 1.5 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF3377 PF11857.6 017194.1_45724001_3 - 2.7 7.9 6.4 6 6.7 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3377) Calc_CGRP_IAPP PF00214.17 012715.1_45723001_1 - 1.7e-29 102.5 0.7 3.5e-29 101.5 0.7 1.5 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family IGF2_C PF08365.9 012715.1_45723001_1 - 0.071 13.0 0.6 0.071 13.0 0.6 2.9 3 0 0 3 3 3 0 Insulin-like growth factor II E-peptide RhoGAP PF00620.25 001012032.1_45726001_3 - 6.1e-49 165.6 0.0 1.2e-48 164.6 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain FPP PF05911.9 001012032.1_45726001_3 - 0.0015 16.8 4.5 0.0025 16.0 4.5 1.3 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil DUF3435 PF11917.6 001012032.1_45726001_3 - 0.072 11.9 4.0 0.11 11.2 4.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) CALCOCO1 PF07888.9 001012032.1_45726001_3 - 0.12 10.8 7.2 0.18 10.2 7.2 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like ATG16 PF08614.9 001012032.1_45726001_3 - 0.6 10.1 13.1 0.017 15.2 6.4 1.8 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DMPK_coil PF08826.8 001012032.1_45726001_3 - 1.5 8.9 15.3 2.2 8.3 4.6 2.9 1 1 1 2 2 2 0 DMPK coiled coil domain like IncA PF04156.12 001012032.1_45726001_3 - 9.3 5.9 12.2 13 5.4 9.8 2.2 2 1 0 2 2 2 0 IncA protein NUDE_C PF04880.11 053347.1_45725001_1 - 1.9e-46 158.6 0.5 1.9e-46 158.6 0.5 2.3 2 0 0 2 2 2 1 NUDE protein, C-terminal conserved region TPR_MLP1_2 PF07926.10 053347.1_45725001_1 - 0.019 14.9 30.9 0.029 14.3 8.3 3.1 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein PRKG1_interact PF15898.3 053347.1_45725001_1 - 0.023 15.5 9.7 0.023 15.5 9.7 2.8 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Pepsin-I3 PF06394.11 053347.1_45725001_1 - 0.19 11.8 2.7 0.45 10.6 2.7 1.6 1 0 0 1 1 1 0 Pepsin inhibitor-3-like repeated domain HIGH_NTase1 PF05636.9 053347.1_45725001_1 - 0.81 8.7 7.6 1.9 7.5 7.6 1.5 1 1 0 1 1 1 0 HIGH Nucleotidyl Transferase ATG16 PF08614.9 053347.1_45725001_1 - 0.85 9.6 37.4 0.97 9.4 19.4 2.5 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Lectin_N PF03954.12 053347.1_45725001_1 - 1 9.0 6.9 0.23 11.1 2.6 2.2 1 1 2 3 3 3 0 Hepatic lectin, N-terminal domain DUF972 PF06156.11 053347.1_45725001_1 - 1.1 9.8 21.3 4.3 7.9 5.6 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF972) HIP1_clath_bdg PF16515.3 053347.1_45725001_1 - 2.1 8.9 23.2 0.041 14.4 10.4 2.6 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 FPP PF05911.9 053347.1_45725001_1 - 2.4 6.2 25.5 0.97 7.5 14.6 2.0 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil DUF1635 PF07795.9 053347.1_45725001_1 - 5.4 6.8 10.1 0.5 10.2 4.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1635) PspA_IM30 PF04012.10 053347.1_45725001_1 - 9.9 5.5 27.2 1.1 8.6 6.8 2.7 1 1 1 2 2 2 0 PspA/IM30 family Nucleos_tra2_C PF07662.11 080908.1_45725001_1 - 5.7e-80 268.0 7.2 5.7e-80 268.0 7.2 2.3 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.18 080908.1_45725001_1 - 1.4e-24 86.4 2.3 1.4e-24 86.4 2.3 3.7 4 0 0 4 4 4 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.12 080908.1_45725001_1 - 1.8e-08 34.5 7.0 1.8e-08 34.5 7.0 3.6 4 0 0 4 4 4 1 Nucleoside recognition ORC6 PF05460.11 080908.1_45725001_1 - 1 8.4 3.2 1.7 7.7 3.2 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) SRP-alpha_N PF04086.11 199383.2_45723001_2 - 0.067 13.0 24.3 0.082 12.7 24.3 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF3807 PF12720.5 199383.2_45723001_2 - 0.22 11.7 23.2 0.32 11.1 23.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Connexin PF00029.17 199383.2_45723001_2 - 1.1 8.9 15.9 1.7 8.3 15.9 1.3 1 0 0 1 1 1 0 Connexin AAA_11 PF13086.4 199383.2_45723001_2 - 4.3 6.9 17.2 5.6 6.5 17.2 1.1 1 0 0 1 1 1 0 AAA domain Yip1 PF04893.15 199383.2_45723001_3 - 2.2e-22 79.4 14.5 3.5e-22 78.8 14.5 1.3 1 0 0 1 1 1 1 Yip1 domain DDHD PF02862.15 199383.2_45723001_3 - 0.18 11.8 6.0 0.22 11.5 6.0 1.1 1 0 0 1 1 1 0 DDHD domain RNA_pol_Rpc4 PF05132.12 199383.2_45723001_3 - 0.84 9.9 18.3 1.3 9.3 18.3 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 EOS1 PF12326.6 199383.2_45723001_3 - 3.8 7.3 8.9 7.1 6.4 8.9 1.5 1 0 0 1 1 1 0 N-glycosylation protein Zfx_Zfy_act PF04704.11 177490.1_06529001_2 - 1.4e-153 510.7 15.9 2.3e-153 510.0 15.9 1.4 1 0 0 1 1 1 1 Zfx / Zfy transcription activation region zf-C2H2 PF00096.24 177490.1_06529001_2 - 5.9e-37 123.9 113.3 2.2e-05 24.5 2.1 13.6 13 0 0 13 13 13 13 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 177490.1_06529001_2 - 1.8e-31 107.0 123.6 7.8e-08 32.3 1.2 14.1 14 0 0 14 14 14 11 Zinc-finger double domain zf-C2H2_4 PF13894.4 177490.1_06529001_2 - 1.4e-26 90.7 108.4 0.00031 21.2 0.9 13.9 13 0 0 13 13 13 13 C2H2-type zinc finger zf-H2C2_5 PF13909.4 177490.1_06529001_2 - 5.5e-24 83.4 97.0 9.7e-07 28.3 5.8 11.6 11 0 0 11 11 11 8 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.6 177490.1_06529001_2 - 2.6e-09 37.0 73.4 0.074 13.3 0.1 12.2 13 0 0 13 13 13 7 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 177490.1_06529001_2 - 9.3e-06 26.2 47.4 0.07 13.8 2.4 7.5 5 1 2 7 7 7 4 zinc-ribbon family zf-C2H2_11 PF16622.3 177490.1_06529001_2 - 0.0013 18.3 59.4 0.046 13.4 0.3 9.2 10 0 0 10 10 10 6 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 177490.1_06529001_2 - 0.0048 16.7 2.5 0.0048 16.7 2.5 9.4 9 0 0 9 9 9 5 C2H2-type zinc finger zf-met PF12874.5 177490.1_06529001_2 - 0.54 10.6 68.0 0.8 10.0 0.0 11.3 11 1 0 11 11 11 0 Zinc-finger of C2H2 type NAD_binding_2 PF03446.13 001007800.1_45724001_1 - 7.2e-39 133.4 0.0 1.5e-38 132.4 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.4 001007800.1_45724001_1 - 5.7e-23 81.3 1.5 1.2e-22 80.4 1.5 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase PWWP PF00855.15 001007800.1_45724001_1 - 2.7e-19 69.3 0.3 6.3e-19 68.1 0.3 1.6 1 0 0 1 1 1 1 PWWP domain F420_oxidored PF03807.15 001007800.1_45724001_1 - 9.8e-08 32.4 0.0 2.4e-07 31.1 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.17 001007800.1_45724001_1 - 3.4e-05 23.1 0.0 0.00027 20.2 0.0 2.1 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.18 001007800.1_45724001_1 - 0.00024 21.0 0.0 0.00047 20.1 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.14 001007800.1_45724001_1 - 0.00036 20.1 0.0 0.00067 19.2 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.16 001007800.1_45724001_1 - 0.003 17.3 0.0 0.007 16.1 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.16 001007800.1_45724001_1 - 0.03 14.4 0.0 0.066 13.3 0.0 1.7 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_Gly3P_dh_N PF01210.21 001007800.1_45724001_1 - 0.14 12.0 0.3 0.41 10.5 0.0 1.9 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus AT_hook PF02178.17 001007800.1_45724001_1 - 3.7 7.6 11.9 0.092 12.5 4.1 2.7 2 0 0 2 2 2 0 AT hook motif PKD_channel PF08016.10 001012059.1_45724001_2 - 8.3e-13 47.7 10.9 8.3e-13 47.7 10.9 1.5 1 1 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.29 001012059.1_45724001_2 - 0.0022 17.1 22.1 0.0062 15.7 22.2 1.7 1 1 0 1 1 1 1 Ion transport protein FGGY_N PF00370.19 001004077.1_45724001_3 - 1.2e-84 283.6 0.0 1.6e-84 283.1 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.14 001004077.1_45724001_3 - 2.8e-63 213.1 0.3 4.7e-63 212.4 0.3 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Cadherin PF00028.15 031320.1_45729001_2 - 2.8e-172 559.6 9.7 2.1e-22 79.2 0.0 9.4 9 0 0 9 9 9 9 Cadherin domain GAIN PF16489.3 031320.1_45729001_2 - 1.7e-56 190.8 0.0 3e-56 190.0 0.0 1.4 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain 7tm_2 PF00002.22 031320.1_45729001_2 - 7.7e-55 185.7 10.6 1.1e-54 185.3 10.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Laminin_G_2 PF02210.22 031320.1_45729001_2 - 7.1e-44 149.3 0.1 4.8e-29 101.4 0.0 2.8 3 0 0 3 3 3 2 Laminin G domain Laminin_G_1 PF00054.21 031320.1_45729001_2 - 2e-27 95.9 0.0 7.2e-20 71.4 0.0 3.0 2 1 0 2 2 2 2 Laminin G domain Cadherin_3 PF16184.3 031320.1_45729001_2 - 1.7e-17 63.3 11.9 0.039 13.8 0.1 7.8 8 0 0 8 8 8 5 Cadherin-like EGF PF00008.25 031320.1_45729001_2 - 9.7e-16 57.6 113.0 1e-06 28.8 8.1 8.6 10 0 0 10 10 8 6 EGF-like domain HRM PF02793.20 031320.1_45729001_2 - 3.6e-11 43.1 0.4 3.6e-11 43.1 0.4 2.6 2 0 0 2 2 1 1 Hormone receptor domain GPS PF01825.19 031320.1_45729001_2 - 6.7e-08 32.9 0.3 2.4e-07 31.2 0.3 2.1 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Cadherin_2 PF08266.10 031320.1_45729001_2 - 1e-06 28.3 0.0 17 5.1 0.0 7.1 7 0 0 7 7 7 0 Cadherin-like Laminin_EGF PF00053.22 031320.1_45729001_2 - 1.1e-06 28.5 12.7 1.1e-06 28.5 12.7 8.6 5 2 3 8 8 7 3 Laminin EGF domain Dicty_CAR PF05462.9 031320.1_45729001_2 - 0.00016 20.8 2.4 0.00032 19.8 2.4 1.4 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor hEGF PF12661.5 031320.1_45729001_2 - 0.11 13.1 102.8 0.0074 16.8 6.8 8.9 10 0 0 10 10 7 0 Human growth factor-like EGF Frizzled PF01534.15 031320.1_45729001_2 - 0.22 10.4 11.8 0.0033 16.4 3.9 1.7 2 0 0 2 2 2 0 Frizzled/Smoothened family membrane region 5-nucleotidase PF06189.10 001011982.1_45724001_1 - 1.6e-102 341.9 0.0 2.4e-102 341.3 0.0 1.2 1 0 0 1 1 1 1 5'-nucleotidase ANAPC3 PF12895.5 001024744.1_45725001_2 - 1.2e-28 99.0 15.2 4.2e-22 78.0 10.4 5.5 3 1 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.15 001024744.1_45725001_2 - 3e-21 73.6 23.8 0.00086 19.1 0.1 10.7 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_1 PF00515.26 001024744.1_45725001_2 - 1.6e-18 65.5 24.4 4.7e-07 29.2 0.2 9.0 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_12 PF13424.4 001024744.1_45725001_2 - 1.5e-14 53.9 16.6 1.2e-08 35.0 0.3 6.4 5 2 1 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.4 001024744.1_45725001_2 - 6.2e-13 47.6 4.7 0.0003 20.5 0.1 5.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.4 001024744.1_45725001_2 - 2e-11 43.0 16.4 0.0024 17.8 0.0 7.3 10 0 0 10 10 6 4 Tetratricopeptide repeat TPR_10 PF13374.4 001024744.1_45725001_2 - 2.3e-11 43.1 3.9 0.0024 17.6 0.3 5.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.4 001024744.1_45725001_2 - 4e-09 36.7 6.5 0.092 13.1 3.2 4.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_9 PF13371.4 001024744.1_45725001_2 - 4.8e-05 23.3 5.7 0.24 11.5 0.0 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_11 PF13414.4 001024744.1_45725001_2 - 4.9e-05 22.8 12.1 0.00013 21.4 0.1 5.5 6 0 0 6 6 6 1 TPR repeat TPR_17 PF13431.4 001024744.1_45725001_2 - 7.9e-05 22.7 4.5 7.8 7.0 0.0 6.5 7 0 0 7 7 6 1 Tetratricopeptide repeat SRP_TPR_like PF17004.3 001024744.1_45725001_2 - 0.0005 20.0 8.7 0.0032 17.3 2.6 3.4 3 0 0 3 3 3 1 Putative TPR-like repeat TPR_14 PF13428.4 001024744.1_45725001_2 - 0.0016 18.9 17.0 12 6.9 0.0 8.0 5 3 2 8 8 7 0 Tetratricopeptide repeat TPR_16 PF13432.4 001024744.1_45725001_2 - 0.0018 18.8 16.6 1.6 9.4 3.3 5.9 5 1 0 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.4 001024744.1_45725001_2 - 0.055 14.0 11.7 1.1 10.0 1.1 5.3 6 0 0 6 6 5 0 Tetratricopeptide repeat ANAPC8 PF04049.11 001024744.1_45725001_2 - 0.096 12.6 2.2 8.2 6.3 2.2 2.4 1 1 0 1 1 1 0 Anaphase promoting complex subunit 8 / Cdc23 Fis1_TPR_C PF14853.4 001024744.1_45725001_2 - 0.29 11.1 10.1 3.9 7.5 0.2 4.5 4 1 1 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat DUF5113 PF17140.2 001024744.1_45725001_2 - 2.8 7.6 8.7 4.5 6.9 0.1 4.2 4 1 1 5 5 5 0 Domain of unknown function (DUF5113) TIR PF01582.18 001009038.1_39725001_1 - 1.6e-27 96.3 0.0 2.9e-27 95.4 0.0 1.4 1 0 0 1 1 1 1 TIR domain Ig_2 PF13895.4 001009038.1_39725001_1 - 1.5e-17 63.6 0.0 1.1e-05 25.5 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Ig_3 PF13927.4 001009038.1_39725001_1 - 3.6e-17 62.6 0.0 3.5e-07 30.6 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 001009038.1_39725001_1 - 1.2e-16 60.4 0.0 3.5e-07 30.1 0.0 3.8 4 0 0 4 4 4 3 Immunoglobulin I-set domain ig PF00047.23 001009038.1_39725001_1 - 9.4e-16 57.6 0.0 3.2e-07 30.3 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 001009038.1_39725001_1 - 6.6e-09 35.8 0.7 0.039 14.0 0.1 5.1 3 3 1 4 4 4 3 Immunoglobulin V-set domain TIR_2 PF13676.4 001009038.1_39725001_1 - 0.00012 22.2 0.0 0.00026 21.1 0.0 1.5 1 0 0 1 1 1 1 TIR domain V-set_CD47 PF08204.9 001009038.1_39725001_1 - 0.0091 15.8 0.1 8.3 6.3 0.0 3.0 3 0 0 3 3 3 2 CD47 immunoglobulin-like domain Izumo-Ig PF16706.3 001009038.1_39725001_1 - 0.01 15.7 0.1 3.4 7.6 0.0 3.3 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Galactosyl_T PF01762.19 214351.1_49824001_2 - 2e-64 216.9 0.1 2.7e-64 216.5 0.1 1.2 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.14 214351.1_49824001_2 - 0.00011 21.7 0.0 0.00016 21.1 0.0 1.1 1 0 0 1 1 1 1 Fringe-like Abhydrolase_1 PF00561.18 001009670.1_45723001_1 - 5.4e-12 45.8 0.1 2e-05 24.2 0.0 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001009670.1_45723001_1 - 5.4e-09 36.9 0.8 8.9e-06 26.4 0.0 2.3 1 1 1 2 2 2 2 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 001009670.1_45723001_1 - 1.4e-08 34.2 0.0 3.9e-05 22.9 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 FSH1 PF03959.11 001009670.1_45723001_1 - 0.0025 17.4 0.2 0.0064 16.0 0.1 1.6 2 0 0 2 2 2 1 Serine hydrolase (FSH1) Abhydrolase_4 PF08386.8 001009670.1_45723001_1 - 0.041 13.9 0.0 0.088 12.8 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein DLH PF01738.16 001009670.1_45723001_1 - 0.083 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family Peptidase_S15 PF02129.16 001009670.1_45723001_1 - 0.096 12.1 0.1 6 6.2 0.0 2.2 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Insulin PF00049.16 001009272.1_22421001_1 - 6.3e-23 81.5 1.2 8e-23 81.1 1.2 1.1 1 0 0 1 1 1 1 Insulin/IGF/Relaxin family Ins_beta PF03488.12 001009272.1_22421001_1 - 0.078 12.9 4.1 0.61 10.0 0.2 2.2 2 0 0 2 2 2 0 Nematode insulin-related peptide beta type Pyridox_oxidase PF01243.18 022601.2_45725001_1 - 2.2e-25 88.5 0.0 4.1e-25 87.7 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase PNPOx_C PF10590.7 022601.2_45725001_1 - 1.4e-17 63.3 0.6 2.9e-17 62.4 0.6 1.5 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Pyridox_oxase_2 PF12766.5 022601.2_45725001_1 - 2e-06 28.2 0.0 3.4e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase WD40 PF00400.30 001013909.1_45725001_1 - 2.5e-19 69.1 11.3 0.0021 18.7 0.1 7.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001013909.1_45725001_1 - 2.1e-08 34.2 0.1 1.1 9.4 0.0 5.4 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 001013909.1_45725001_1 - 0.0033 16.3 0.5 1.3 7.7 0.0 3.4 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein zf-CCCH PF00642.22 001012351.2_45724001_1 - 7.8e-17 60.6 37.9 5.6e-07 29.2 0.5 5.9 6 0 0 6 6 6 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.3 001012351.2_45724001_1 - 7e-10 39.0 19.3 2.1e-09 37.5 8.0 2.8 1 1 1 2 2 2 2 Zinc-finger containing family Torus PF16131.3 001012351.2_45724001_1 - 2.8e-07 31.0 29.3 0.00068 20.2 0.4 5.2 1 1 4 5 5 5 4 Torus domain zf-CCHC PF00098.21 001012351.2_45724001_1 - 5.7e-06 26.0 3.6 5.7e-06 26.0 3.6 3.0 2 0 0 2 2 2 1 Zinc knuckle zf-CCCH_2 PF14608.4 001012351.2_45724001_1 - 0.079 13.3 40.5 0.93 9.9 3.0 6.7 6 1 0 6 6 6 0 RNA-binding, Nab2-type zinc finger zf-C3H1 PF10650.7 001012351.2_45724001_1 - 0.46 10.2 13.4 2.2 7.9 0.2 4.2 4 0 0 4 4 4 0 Putative zinc-finger domain FBA PF04300.11 001001414.1_26224001_2 - 8.2e-43 146.2 0.0 1.8e-42 145.1 0.0 1.5 2 0 0 2 2 2 1 F-box associated region LAT PF15234.4 030853.1_45723001_2 - 1.4e-121 404.6 17.2 1.7e-121 404.4 17.2 1.1 1 0 0 1 1 1 1 Linker for activation of T-cells Histone PF00125.22 001009270.1_39522001_3 - 1.6e-18 67.3 0.0 2.2e-18 66.8 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.3 001009270.1_39522001_3 - 1.6e-12 46.8 0.5 2.9e-12 46.0 0.5 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.21 001009270.1_39522001_3 - 0.024 14.8 0.0 0.037 14.2 0.0 1.3 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF106 PF01956.14 001009631.1_45723001_2 - 5.3e-43 146.6 1.0 9.5e-43 145.7 1.0 1.4 1 0 0 1 1 1 1 Integral membrane protein DUF106 Vpu PF00558.17 001009631.1_45723001_2 - 0.013 15.1 0.4 0.026 14.2 0.4 1.5 1 0 0 1 1 1 0 Vpu protein DivIC PF04977.13 001009631.1_45723001_2 - 2.4 7.8 11.0 0.31 10.7 0.5 2.4 1 1 1 2 2 2 0 Septum formation initiator RWD PF05773.20 147146.2_45723001_3 - 9.6e-27 93.4 1.8 2.1e-26 92.4 1.8 1.6 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.3 147146.2_45723001_3 - 6.7e-07 29.6 4.7 6.7e-07 29.6 4.7 2.8 2 1 1 3 3 3 1 DRG Family Regulatory Proteins, Tma46 Folliculin PF11704.6 147146.2_45723001_3 - 0.13 11.9 0.9 0.2 11.4 0.9 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport BUD22 PF09073.8 147146.2_45723001_3 - 0.16 11.1 8.4 0.24 10.5 8.4 1.2 1 0 0 1 1 1 0 BUD22 RRM_1 PF00076.20 026025.2_32922001_2 - 7.9e-21 73.5 0.2 1.3e-20 72.8 0.2 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 026025.2_32922001_2 - 1.1e-07 31.3 0.0 1.8e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.21 026025.2_32922001_2 - 2.8e-05 23.9 2.2 5e-05 23.0 2.2 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.4 026025.2_32922001_2 - 0.019 14.8 1.1 0.034 14.0 1.1 1.4 1 0 0 1 1 1 0 Zinc knuckle RRM_7 PF16367.3 026025.2_32922001_2 - 0.033 14.2 0.0 0.073 13.1 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif T2SSS_2 PF16549.3 026025.2_32922001_2 - 0.092 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Type II secretion system (T2SS) pilotin, S protein BRAP2 PF07576.10 026025.2_32922001_2 - 0.11 12.6 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 BRCA1-associated protein 2 Kelch_1 PF01344.23 006469.4_26229001_3 - 7.3e-82 268.6 23.5 9.9e-16 56.9 0.1 7.2 7 0 0 7 7 7 6 Kelch motif Kelch_6 PF13964.4 006469.4_26229001_3 - 1.9e-41 138.9 6.2 1e-09 38.2 0.0 6.6 1 1 5 6 6 6 6 Kelch motif Kelch_2 PF07646.13 006469.4_26229001_3 - 3.6e-33 112.2 3.9 4e-05 23.3 0.0 6.9 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.4 006469.4_26229001_3 - 4.4e-32 109.6 9.9 6e-08 32.6 0.1 6.6 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.4 006469.4_26229001_3 - 5.9e-29 99.6 1.4 4.7e-06 26.3 0.1 6.0 5 1 1 6 6 6 5 Galactose oxidase, central domain BTB PF00651.29 006469.4_26229001_3 - 4.1e-26 91.3 0.2 7e-26 90.5 0.2 1.3 1 0 0 1 1 1 1 BTB/POZ domain Kelch_5 PF13854.4 006469.4_26229001_3 - 8.1e-15 54.3 9.2 0.00019 21.2 0.1 5.8 6 0 0 6 6 6 4 Kelch motif BACK PF07707.13 006469.4_26229001_3 - 2.8e-12 46.5 0.5 5.6e-12 45.5 0.2 1.6 2 0 0 2 2 2 1 BTB And C-terminal Kelch XPA_C PF05181.10 006469.4_26229001_3 - 0.16 11.8 0.4 22 5.0 0.0 3.1 2 0 0 2 2 2 0 XPA protein C-terminus PQQ_3 PF13570.4 006469.4_26229001_3 - 0.45 10.9 2.3 13 6.3 0.1 3.8 4 0 0 4 4 4 0 PQQ-like domain CENP-I PF07778.9 012955.1_45727001_2 - 3.3e-287 953.1 17.5 4.1e-287 952.8 17.5 1.1 1 0 0 1 1 1 1 Mis6 CUB PF00431.18 213836.1_49822001_3 - 4.3e-11 43.0 0.0 5.8e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 CUB domain Pou PF00157.15 001009350.1_39522001_1 - 2.1e-35 120.4 0.9 1.4e-33 114.5 0.3 2.4 2 0 0 2 2 2 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 001009350.1_39522001_1 - 7.4e-18 64.0 3.0 1.8e-17 62.7 3.0 1.7 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001009350.1_39522001_1 - 0.022 14.5 0.1 0.073 12.8 0.1 1.9 1 0 0 1 1 1 0 Homeobox KN domain HTH_31 PF13560.4 001009350.1_39522001_1 - 0.046 13.9 0.0 2.9 8.2 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Carb_anhydrase PF00194.19 001008688.1_49824001_3 - 1e-89 300.3 0.0 1.2e-89 300.0 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase bZIP_1 PF00170.19 172336.3_45723001_3 - 2.5e-12 46.6 9.9 2.5e-12 46.6 9.9 1.8 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.13 172336.3_45723001_3 - 1.2e-06 28.4 12.8 1.2e-06 28.4 12.8 1.7 2 0 0 2 2 2 1 Basic region leucine zipper PI-PLC-X PF00388.17 080688.1_45726001_2 - 1.9e-61 205.8 0.0 4e-61 204.7 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.17 080688.1_45726001_2 - 6.9e-42 142.3 1.5 1.2e-41 141.5 0.1 2.1 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.9 080688.1_45726001_2 - 6e-36 122.7 0.3 2e-35 121.0 0.3 2.0 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_10 PF14788.4 080688.1_45726001_2 - 3.6e-18 65.0 1.9 3.6e-18 65.0 1.9 2.3 2 0 0 2 2 2 1 EF hand C2 PF00168.28 080688.1_45726001_2 - 1.2e-17 63.9 0.1 2.4e-17 63.0 0.1 1.5 1 0 0 1 1 1 1 C2 domain PH PF00169.27 080688.1_45726001_2 - 1.4e-08 35.1 0.2 9.6e-08 32.4 0.0 2.4 2 0 0 2 2 2 1 PH domain EF-hand_7 PF13499.4 080688.1_45726001_2 - 2.4e-07 31.0 5.1 0.0022 18.3 3.2 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 080688.1_45726001_2 - 3.1e-07 29.7 2.9 0.075 12.9 0.0 3.9 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.30 080688.1_45726001_2 - 3.3e-06 26.1 0.5 0.047 13.1 0.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.4 080688.1_45726001_2 - 0.00059 19.1 0.2 1.1 8.8 0.0 2.8 2 0 0 2 2 2 2 EF hand PH_12 PF16457.3 080688.1_45726001_2 - 0.00069 20.0 1.6 0.0019 18.6 0.1 2.6 2 1 0 2 2 2 1 Pleckstrin homology domain GDPD PF03009.15 080688.1_45726001_2 - 0.0044 16.7 0.0 0.0088 15.7 0.0 1.5 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family EF-hand_8 PF13833.4 080688.1_45726001_2 - 0.03 14.0 0.2 0.1 12.3 0.2 2.0 1 0 0 1 1 1 0 EF-hand domain pair IGFBP PF00219.16 031590.1_45724001_1 - 1.4e-08 35.1 23.6 1.4e-08 35.1 23.6 3.0 2 1 0 2 2 2 1 Insulin-like growth factor binding protein VWC PF00093.16 031590.1_45724001_1 - 3.1e-07 30.5 10.4 3.1e-07 30.5 10.4 2.9 2 0 0 2 2 2 1 von Willebrand factor type C domain SH3_9 PF14604.4 001002289.1_45724001_1 - 4.5e-10 39.1 0.0 1e-09 37.9 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain O-FucT PF10250.7 001002289.1_45724001_1 - 9.2e-05 22.1 0.0 0.00024 20.8 0.0 1.6 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase SH3_1 PF00018.26 001002289.1_45724001_1 - 9.9e-05 21.7 0.0 0.00021 20.7 0.0 1.6 1 0 0 1 1 1 1 SH3 domain IncA PF04156.12 001002289.1_45724001_1 - 0.13 11.9 1.2 0.27 10.9 1.2 1.5 1 0 0 1 1 1 0 IncA protein DivIC PF04977.13 001002289.1_45724001_1 - 0.24 11.1 2.7 9.4 5.9 0.0 3.6 3 0 0 3 3 3 0 Septum formation initiator Wtap PF17098.3 001002289.1_45724001_1 - 1.2 9.0 6.2 31 4.3 6.2 2.4 1 1 0 1 1 1 0 WTAP/Mum2p family DUF1043 PF06295.10 001002289.1_45724001_1 - 4 7.3 6.2 2.2 8.2 0.6 2.9 3 1 1 4 4 4 0 Protein of unknown function (DUF1043) Homeobox_KN PF05920.9 001009067.1_39722001_3 - 1e-17 63.6 0.6 2e-17 62.7 0.6 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 001009067.1_39722001_3 - 1.4e-06 27.9 0.4 3.1e-06 26.8 0.4 1.6 1 0 0 1 1 1 1 Homeobox domain AICARFT_IMPCHas PF01808.16 001009067.1_39722001_3 - 0.14 11.5 0.0 0.2 10.9 0.0 1.1 1 0 0 1 1 1 0 AICARFT/IMPCHase bienzyme NPBW PF15180.4 213786.1_49822001_3 - 2.7e-27 94.8 0.0 4.9e-27 93.9 0.0 1.5 1 1 0 1 1 1 1 Neuropeptides B and W Lectin_C PF00059.19 213990.1_49822001_3 - 5.6e-16 59.1 1.5 8.5e-16 58.5 1.5 1.3 1 0 0 1 1 1 1 Lectin C-type domain Serpin PF00079.18 001009304.1_39523001_1 - 1e-93 314.5 13.6 1.4e-93 314.1 13.6 1.2 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) N1221 PF07923.11 001009304.1_39523001_1 - 0.0055 15.8 2.7 0.0095 15.0 2.3 1.6 1 1 0 1 1 1 1 N1221-like protein Lipase_GDSL PF00657.20 138898.1_45729001_3 - 3.1e-71 239.3 0.0 3.9e-25 88.9 0.0 4.1 4 0 0 4 4 4 3 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.4 138898.1_45729001_3 - 5.1e-17 62.7 1.0 1.6e-06 28.6 0.0 4.8 3 3 0 3 3 3 3 GDSL-like Lipase/Acylhydrolase family TNF PF00229.16 213806.1_49822001_1 - 1.3e-33 115.5 2.2 1.8e-33 115.1 2.2 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family Ni_hydr_CYTB PF01292.18 213806.1_49822001_1 - 0.081 12.4 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 POM121 PF15229.4 053622.1_45729001_3 - 1.3e-108 362.0 23.0 1.3e-108 362.0 23.0 3.0 2 1 0 2 2 2 1 POM121 family LANC_like PF05147.11 001014187.1_45724001_1 - 2.2e-104 348.7 0.1 2.7e-104 348.4 0.1 1.1 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein C5-epim_C PF06662.11 001014187.1_45724001_1 - 2.8e-05 23.6 0.1 0.062 12.7 0.0 3.1 3 0 0 3 3 3 2 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_127 PF07944.10 001014187.1_45724001_1 - 0.00013 20.5 0.1 0.087 11.2 0.0 2.2 2 0 0 2 2 2 2 Beta-L-arabinofuranosidase, GH127 Glyco_hydro_88 PF07470.11 001014187.1_45724001_1 - 0.011 14.7 0.6 0.14 11.1 0.1 2.5 2 1 1 3 3 3 0 Glycosyl Hydrolase Family 88 Glyco_hydro_76 PF03663.12 001014187.1_45724001_1 - 0.5 9.7 1.3 15 4.8 0.4 2.9 2 1 0 2 2 2 0 Glycosyl hydrolase family 76 IL8 PF00048.18 001013045.1_45723001_3 - 6.4e-20 70.9 1.6 1.5e-19 69.8 1.6 1.7 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like EOS1 PF12326.6 001007005.1_45724001_1 - 5.6 6.7 7.2 7.9 6.2 7.2 1.2 1 0 0 1 1 1 0 N-glycosylation protein Rho_GDI PF02115.15 001007005.1_45724001_2 - 1.6e-80 269.2 0.3 1.6e-80 269.2 0.3 1.8 2 0 0 2 2 2 1 RHO protein GDP dissociation inhibitor EOS1 PF12326.6 001007005.1_45724001_2 - 4.9 6.9 6.5 7.8 6.3 6.5 1.3 1 0 0 1 1 1 0 N-glycosylation protein RNA_pol_Rpc4 PF05132.12 001007005.1_45724001_3 - 0.38 11.1 15.4 0.04 14.2 11.2 1.5 2 0 0 2 2 2 0 RNA polymerase III RPC4 Pkinase PF00069.23 022184.1_45728001_1 - 4e-68 229.5 0.0 6.9e-68 228.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Guanylate_kin PF00625.19 022184.1_45728001_1 - 6e-61 205.2 0.1 1.1e-60 204.3 0.1 1.4 1 0 0 1 1 1 1 Guanylate kinase Pkinase_Tyr PF07714.15 022184.1_45728001_1 - 6.5e-30 104.1 0.0 1.1e-29 103.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase L27 PF02828.14 022184.1_45728001_1 - 2.5e-23 81.4 13.6 1.6e-13 50.1 0.6 4.0 4 0 0 4 4 4 2 L27 domain PDZ PF00595.22 022184.1_45728001_1 - 1.2e-16 60.7 0.5 2.4e-16 59.7 0.5 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) SH3_2 PF07653.15 022184.1_45728001_1 - 1.5e-12 46.9 0.0 3.4e-12 45.7 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 022184.1_45728001_1 - 4.8e-08 32.3 0.1 1.2e-07 31.1 0.1 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 022184.1_45728001_1 - 7.3e-05 22.4 0.0 0.00017 21.2 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Kinase-like PF14531.4 022184.1_45728001_1 - 0.00071 18.8 0.0 0.016 14.4 0.0 2.2 2 0 0 2 2 2 1 Kinase-like PDZ_2 PF13180.4 022184.1_45728001_1 - 0.0044 17.2 0.0 0.011 15.9 0.0 1.6 1 0 0 1 1 1 1 PDZ domain AMH_N PF04709.10 012902.1_45724001_1 - 1.8e-133 445.1 7.6 2.3e-133 444.7 7.6 1.1 1 0 0 1 1 1 1 Anti-Mullerian hormone, N terminal region TGF_beta PF00019.18 012902.1_45724001_1 - 2.6e-15 57.0 0.3 3.9e-15 56.5 0.3 1.3 1 0 0 1 1 1 1 Transforming growth factor beta like domain TAS2R PF05296.11 001024686.1_45722001_1 - 8.1e-86 287.7 33.4 9.1e-86 287.6 33.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Filament PF00038.19 001008820.1_45723001_1 - 1.8e-109 366.0 30.0 2.1e-109 365.8 30.0 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 001008820.1_45723001_1 - 0.011 15.7 32.2 0.064 13.2 2.3 3.8 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein DUF5082 PF16888.3 001008820.1_45723001_1 - 0.011 16.0 5.8 0.011 16.0 5.8 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) Lzipper-MIP1 PF14389.4 001008820.1_45723001_1 - 0.014 15.5 1.9 0.014 15.5 1.9 4.4 3 2 1 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 DivIC PF04977.13 001008820.1_45723001_1 - 0.034 13.8 20.6 0.34 10.6 0.5 5.1 5 0 0 5 5 5 0 Septum formation initiator POX PF07526.9 001008820.1_45723001_1 - 0.045 14.2 3.1 0.26 11.7 2.8 2.1 2 0 0 2 2 2 0 Associated with HOX DUF2551 PF10826.6 001008820.1_45723001_1 - 0.12 12.4 0.3 1.3 9.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2551) Fib_alpha PF08702.8 001008820.1_45723001_1 - 0.13 12.3 16.4 3 7.9 6.3 3.6 2 1 4 6 6 6 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.10 001008820.1_45723001_1 - 0.14 12.0 12.2 5.5 6.9 1.8 4.0 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) Uso1_p115_C PF04871.11 001008820.1_45723001_1 - 0.39 11.0 21.2 1.2 9.4 2.4 3.2 2 2 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region G6PD_N PF00479.20 001008820.1_45723001_1 - 0.53 10.8 7.2 0.6 10.6 0.2 2.9 2 1 1 3 3 3 0 Glucose-6-phosphate dehydrogenase, NAD binding domain Reo_sigmaC PF04582.10 001008820.1_45723001_1 - 0.78 8.9 5.5 1 8.5 0.8 2.6 2 1 1 3 3 3 0 Reovirus sigma C capsid protein UPF0184 PF03670.11 001008820.1_45723001_1 - 0.88 9.9 16.3 1.8 8.8 0.1 4.1 2 1 1 4 4 4 0 Uncharacterised protein family (UPF0184) Atg14 PF10186.7 001008820.1_45723001_1 - 1.2 8.0 22.9 9.9 5.0 8.1 2.9 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF724 PF05266.12 001008820.1_45723001_1 - 1.6 8.4 13.4 0.62 9.7 3.3 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF724) DUF972 PF06156.11 001008820.1_45723001_1 - 1.8 9.1 25.0 11 6.6 0.8 5.2 2 2 3 5 5 5 0 Protein of unknown function (DUF972) Bacillus_HBL PF05791.9 001008820.1_45723001_1 - 2 8.0 10.0 0.14 11.7 1.3 3.0 3 1 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) SKA1 PF07160.10 001008820.1_45723001_1 - 2.8 7.6 16.3 0.58 9.8 4.4 3.1 1 1 2 3 3 3 0 Spindle and kinetochore-associated protein 1 Prefoldin_2 PF01920.18 001008820.1_45723001_1 - 3.1 7.7 18.7 9.3 6.1 0.5 4.5 3 1 1 4 4 4 0 Prefoldin subunit SlyX PF04102.10 001008820.1_45723001_1 - 3.2 8.3 24.8 2.1 8.9 0.3 4.7 4 1 1 5 5 4 0 SlyX Jnk-SapK_ap_N PF09744.7 001008820.1_45723001_1 - 3.8 7.6 28.4 0.74 9.9 4.1 3.7 2 2 2 4 4 4 0 JNK_SAPK-associated protein-1 CENP-F_leu_zip PF10473.7 001008820.1_45723001_1 - 5 7.0 33.8 2.3 8.1 9.1 4.1 2 2 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 zf-Di19 PF05605.10 001001517.1_45725001_2 - 3.5e-16 59.1 2.3 3.5e-16 59.1 2.3 3.7 4 1 0 4 4 3 1 Drought induced 19 protein (Di19), zinc-binding zf-RING_UBOX PF13445.4 001001517.1_45725001_2 - 1.3e-08 34.6 10.4 1.3e-08 34.6 10.4 2.9 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001001517.1_45725001_2 - 1.5e-07 31.0 11.4 1.5e-07 31.0 11.4 4.1 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001001517.1_45725001_2 - 2.6e-07 30.3 9.9 2.6e-07 30.3 9.9 4.4 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001001517.1_45725001_2 - 5.4e-07 29.5 14.0 5.4e-07 29.5 14.0 3.8 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 001001517.1_45725001_2 - 8.1e-07 28.6 13.1 8.1e-07 28.6 13.1 3.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001001517.1_45725001_2 - 1.2e-06 28.5 11.5 1.2e-06 28.5 11.5 3.9 3 1 1 4 4 4 1 Ring finger domain zf-RING_5 PF14634.4 001001517.1_45725001_2 - 5e-06 26.2 11.2 5e-06 26.2 11.2 4.1 4 0 0 4 4 3 1 zinc-RING finger domain zf-RING_6 PF14835.4 001001517.1_45725001_2 - 0.0011 18.7 4.0 0.0011 18.7 4.0 2.2 2 0 0 2 2 2 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.4 001001517.1_45725001_2 - 0.0076 15.9 11.1 0.0076 15.9 11.1 3.4 4 0 0 4 4 4 1 Prokaryotic RING finger family 4 U-box PF04564.13 001001517.1_45725001_2 - 0.0086 16.1 0.0 0.019 15.0 0.0 1.5 1 0 0 1 1 1 1 U-box domain Methyltransf_15 PF09445.8 001001517.1_45725001_2 - 0.17 11.5 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Rtf2 PF04641.10 001001517.1_45725001_2 - 1.7 7.8 8.1 0.98 8.6 5.6 1.8 1 1 0 1 1 1 0 Rtf2 RING-finger Cadherin PF00028.15 001037158.1_45729001_2 - 2.8e-83 274.4 0.9 1.2e-17 64.0 0.0 6.4 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001037158.1_45729001_2 - 2.6e-36 123.1 0.3 5e-32 109.4 0.0 4.1 5 0 0 5 5 5 2 Cadherin-like Cadherin_tail PF15974.3 001037158.1_45729001_2 - 8.2e-26 90.8 2.8 1.6e-25 89.8 2.8 1.5 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 001037158.1_45729001_2 - 9.5e-23 80.7 0.2 3.8e-22 78.7 0.2 2.1 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001037158.1_45729001_2 - 0.0047 16.8 5.7 2.5 8.0 0.1 4.6 4 1 0 4 4 4 2 Cadherin-like TMEM154 PF15102.4 001037158.1_45729001_2 - 0.18 11.6 0.1 0.38 10.5 0.1 1.4 1 0 0 1 1 1 0 TMEM154 protein family MFS_1 PF07690.14 013031.1_45726001_2 - 1.7e-44 152.0 39.9 4.9e-38 130.8 28.9 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily 7tm_1 PF00001.19 001001267.1_49823001_1 - 2.3e-67 227.0 10.6 3e-67 226.6 10.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001001267.1_49823001_1 - 0.00041 20.0 9.1 0.00041 20.0 9.1 1.6 2 1 0 2 2 2 1 Olfactory receptor DUF621 PF04789.13 001001267.1_49823001_1 - 1.1 8.2 11.2 2 7.4 11.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF621) Mtc PF03820.15 001013072.1_45725001_2 - 1e-58 198.8 0.2 1.4e-58 198.3 0.2 1.2 1 0 0 1 1 1 1 Tricarboxylate carrier V-set PF07686.15 019243.1_45729001_2 - 4.7e-37 126.3 4.5 3.6e-08 33.4 0.1 6.4 6 0 0 6 6 6 6 Immunoglobulin V-set domain Ig_3 PF13927.4 019243.1_45729001_2 - 2.5e-30 104.8 2.2 3e-05 24.4 0.0 7.2 6 1 0 6 6 6 5 Immunoglobulin domain I-set PF07679.14 019243.1_45729001_2 - 1.8e-20 72.6 0.0 0.00024 21.0 0.0 6.9 6 0 0 6 6 6 5 Immunoglobulin I-set domain ig PF00047.23 019243.1_45729001_2 - 6.9e-20 70.9 6.4 0.0001 22.3 0.0 8.1 6 3 0 6 6 6 4 Immunoglobulin domain Ig_2 PF13895.4 019243.1_45729001_2 - 1.1e-14 54.4 3.6 0.14 12.4 0.0 8.0 6 3 0 6 6 6 4 Immunoglobulin domain Izumo-Ig PF16706.3 019243.1_45729001_2 - 0.00016 21.5 0.5 3.5 7.6 0.0 5.3 7 0 0 7 7 7 1 Izumo-like Immunoglobulin domain P2X_receptor PF00864.17 080780.2_45725001_2 - 8.6e-158 525.1 0.1 1.1e-157 524.8 0.1 1.1 1 0 0 1 1 1 1 ATP P2X receptor DUF2870 PF11069.6 080780.2_45725001_2 - 0.14 12.4 0.8 0.26 11.5 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2870) Lipase PF00151.17 032081.1_45724001_1 - 1.5e-152 507.6 0.0 1.8e-152 507.3 0.0 1.1 1 0 0 1 1 1 1 Lipase PLAT PF01477.21 032081.1_45724001_1 - 5.6e-15 55.8 0.0 1.4e-14 54.5 0.0 1.6 1 0 0 1 1 1 1 PLAT/LH2 domain Abhydrolase_6 PF12697.5 032081.1_45724001_1 - 0.00029 21.4 0.0 0.00054 20.5 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.12 032081.1_45724001_1 - 0.0039 16.6 0.1 0.0064 15.9 0.1 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_3 PF07859.11 032081.1_45724001_1 - 0.013 15.2 0.0 0.021 14.6 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_2 PF01674.16 032081.1_45724001_1 - 0.022 14.1 0.2 0.039 13.3 0.2 1.3 1 0 0 1 1 1 0 Lipase (class 2) LIDHydrolase PF10230.7 032081.1_45724001_1 - 0.024 14.1 0.0 0.034 13.6 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Lipase_3 PF01764.23 032081.1_45724001_1 - 0.042 13.6 0.0 0.079 12.7 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) DUF900 PF05990.10 032081.1_45724001_1 - 0.048 13.0 0.0 0.073 12.4 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Hydrolase_4 PF12146.6 032081.1_45724001_1 - 0.07 12.2 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Brr6_like_C_C PF10104.7 032081.1_45724001_1 - 0.09 12.4 1.5 0.09 12.4 0.1 1.6 2 0 0 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain PPTA PF01239.20 032081.1_45724001_3 - 7.2 6.4 6.1 31 4.4 0.4 2.5 2 0 0 2 2 2 0 Protein prenyltransferase alpha subunit repeat DLIC PF05783.9 001013940.1_45724001_2 - 4.1e-08 32.4 0.1 5e-07 28.8 0.0 2.0 1 1 1 2 2 2 2 Dynein light intermediate chain (DLIC) Roc PF08477.11 001013940.1_45724001_2 - 0.058 13.5 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Atg8 PF02991.14 022706.2_45724001_3 - 9.8e-49 163.7 0.1 1.5e-48 163.1 0.1 1.3 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.11 022706.2_45724001_3 - 7.7e-05 22.9 0.0 0.00011 22.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Lipoxygenase PF00305.17 213931.1_49826001_2 - 1.9e-58 198.4 0.0 9e-57 192.8 0.0 2.7 1 1 0 1 1 1 1 Lipoxygenase PLAT PF01477.21 213931.1_49826001_2 - 1.9e-21 76.7 0.0 3.2e-21 75.9 0.0 1.3 1 0 0 1 1 1 1 PLAT/LH2 domain UL11 PF11094.6 213931.1_49826001_3 - 0.56 10.0 2.1 2.3 8.1 2.1 2.1 1 0 0 1 1 1 0 Membrane-associated tegument protein CIAPIN1 PF05093.11 001007689.1_45724001_1 - 6.4e-23 81.0 18.5 9.9e-17 61.2 3.5 3.3 2 1 1 3 3 3 2 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Methyltransf_11 PF08241.10 001007689.1_45724001_1 - 0.0019 18.6 0.0 0.0048 17.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 001007689.1_45724001_1 - 0.013 16.0 0.0 0.034 14.7 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Tat PF00539.16 001007689.1_45724001_1 - 0.041 13.9 0.7 0.041 13.9 0.7 2.5 2 0 0 2 2 2 0 Transactivating regulatory protein (Tat) Methyltransf_23 PF13489.4 001007689.1_45724001_1 - 0.058 13.2 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Ras PF00071.20 001015012.1_45723001_2 - 1.1e-42 145.2 2.6 1.3e-37 128.7 0.3 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.11 001015012.1_45723001_2 - 6.3e-26 90.8 0.5 1.8e-19 70.0 0.0 2.5 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001015012.1_45723001_2 - 7e-09 35.3 0.5 3.1e-08 33.2 0.1 1.8 1 1 1 2 2 2 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001015012.1_45723001_2 - 2.1e-05 23.9 0.1 0.0002 20.6 0.0 1.9 1 1 1 2 2 2 1 Gtr1/RagA G protein conserved region DUF258 PF03193.14 001015012.1_45723001_2 - 8.6e-05 22.4 0.1 0.17 11.6 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_22 PF13401.4 001015012.1_45723001_2 - 0.0053 16.9 0.0 0.015 15.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain PduV-EutP PF10662.7 001015012.1_45723001_2 - 0.013 15.1 0.2 0.29 10.7 0.1 2.1 1 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.25 001015012.1_45723001_2 - 0.014 14.8 0.0 0.047 13.1 0.0 1.7 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain FeoB_N PF02421.16 001015012.1_45723001_2 - 0.025 14.0 0.1 3.6 7.0 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B ATP_bind_1 PF03029.15 001015012.1_45723001_2 - 0.026 14.2 0.5 2.5 7.7 0.1 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_16 PF13191.4 001015012.1_45723001_2 - 0.032 14.5 0.1 0.05 13.8 0.1 1.3 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.12 001015012.1_45723001_2 - 0.032 14.1 0.2 0.27 11.1 0.0 2.0 1 1 1 2 2 2 0 AAA domain (dynein-related subfamily) NACHT PF05729.10 001015012.1_45723001_2 - 0.037 13.8 0.0 0.072 12.9 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_28 PF13521.4 001015012.1_45723001_2 - 0.044 13.9 0.2 0.14 12.3 0.2 1.7 1 1 0 1 1 1 0 AAA domain TsaE PF02367.15 001015012.1_45723001_2 - 0.1 12.4 0.3 0.59 10.0 0.3 2.1 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PurA PF04845.11 001017503.1_45725001_1 - 1.1e-97 325.5 0.0 2.3e-97 324.5 0.0 1.5 2 0 0 2 2 2 1 PurA ssDNA and RNA-binding protein DUF3276 PF11680.6 001017503.1_45725001_1 - 0.23 11.5 1.4 13 5.8 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3276) IATP PF04568.10 001017503.1_45725001_1 - 2.4 8.5 4.9 2.5 8.4 1.6 2.6 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP GIT_CC PF16559.3 138870.1_45722001_1 - 0.046 13.6 0.4 0.08 12.9 0.4 1.3 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor MAD PF05557.11 138870.1_45722001_1 - 0.13 10.5 5.2 0.17 10.1 5.2 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein RFX1_trans_act PF04589.11 001012172.1_45725001_1 - 4.2e-35 121.1 33.4 1.5e-34 119.3 33.4 1.9 1 1 0 1 1 1 1 RFX1 transcription activation region RFX_DNA_binding PF02257.13 001012172.1_45725001_1 - 1.8e-19 70.0 0.7 2.4e-17 63.2 0.7 2.5 1 1 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.14 001012172.1_45725001_1 - 0.42 11.0 0.0 0.42 11.0 0.0 2.1 2 0 0 2 2 2 0 Poxvirus D5 protein-like HisKA PF00512.23 001012172.1_45725001_2 - 0.097 12.6 0.2 0.19 11.6 0.2 1.5 1 0 0 1 1 1 0 His Kinase A (phospho-acceptor) domain eIF-1a PF01176.17 001008977.1_39722001_2 - 4e-21 74.5 0.1 5.9e-21 73.9 0.1 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 TAS2R PF05296.11 023994.1_45722001_1 - 2.1e-87 293.0 41.8 2.3e-87 292.8 41.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF4811 PF16069.3 023994.1_45722001_1 - 0.25 11.1 2.4 0.57 9.9 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4811) Calponin PF00402.16 001009456.1_39523001_2 - 9.4e-43 143.3 21.2 1.8e-15 56.1 2.4 3.4 3 0 0 3 3 3 3 Calponin family repeat CH PF00307.29 001009456.1_39523001_2 - 6.6e-24 84.1 0.1 1e-23 83.5 0.1 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain CDC24 PF06395.9 001009456.1_39523001_2 - 0.089 13.0 0.1 0.15 12.3 0.1 1.3 1 0 0 1 1 1 0 CDC24 Calponin CAMSAP_CH PF11971.6 001009456.1_39523001_2 - 0.13 12.0 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 CAMSAP CH domain Tropomyosin PF00261.18 001001632.1_49822001_3 - 3.6e-87 291.5 61.3 4.1e-87 291.3 61.3 1.0 1 0 0 1 1 1 1 Tropomyosin Tropomyosin_1 PF12718.5 001001632.1_49822001_3 - 1.4e-24 86.7 57.5 1.1e-19 70.8 28.5 3.1 1 1 2 3 3 3 3 Tropomyosin like Laminin_II PF06009.10 001001632.1_49822001_3 - 9.5e-07 28.8 24.9 2.2e-05 24.4 3.9 3.4 1 1 1 3 3 3 2 Laminin Domain II TMF_DNA_bd PF12329.6 001001632.1_49822001_3 - 0.00071 19.4 11.5 0.00071 19.4 11.5 4.8 3 1 2 5 5 4 2 TATA element modulatory factor 1 DNA binding YscO PF07321.10 001001632.1_49822001_3 - 0.0086 15.9 20.4 0.0086 15.9 20.4 4.3 1 1 3 4 4 3 1 Type III secretion protein YscO CENP-F_leu_zip PF10473.7 001001632.1_49822001_3 - 0.025 14.4 54.3 0.016 15.1 30.2 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CLZ PF16526.3 001001632.1_49822001_3 - 0.029 14.6 4.2 0.029 14.6 4.2 4.9 2 2 3 5 5 5 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels WES_acyltransf PF03007.14 001001632.1_49822001_3 - 0.038 13.6 2.8 0.067 12.8 2.8 1.4 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain Reo_sigmaC PF04582.10 001001632.1_49822001_3 - 0.046 13.0 1.6 0.95 8.7 0.1 2.1 2 0 0 2 2 2 0 Reovirus sigma C capsid protein DUF745 PF05335.11 001001632.1_49822001_3 - 0.079 12.6 35.5 0.13 11.9 25.2 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF745) DUF1664 PF07889.10 001001632.1_49822001_3 - 0.13 12.1 23.5 0.38 10.6 3.6 3.5 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) MAD PF05557.11 001001632.1_49822001_3 - 0.16 10.1 46.0 0.13 10.5 24.2 2.0 1 1 1 2 2 2 0 Mitotic checkpoint protein UPF0693 PF16088.3 001001632.1_49822001_3 - 0.21 11.7 8.2 0.64 10.2 0.1 3.6 2 2 2 4 4 4 0 UPF0693 family DUF1794 PF08768.9 001001632.1_49822001_3 - 0.29 11.0 3.5 7.8 6.3 0.1 2.8 2 1 0 3 3 3 0 Domain of unknown function (DUF1794) Golgin_A5 PF09787.7 001001632.1_49822001_3 - 0.32 10.3 46.7 0.019 14.3 14.7 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 CPG4 PF15481.4 001001632.1_49822001_3 - 0.44 11.1 7.5 1.4 9.5 0.6 3.0 2 1 2 4 4 2 0 Chondroitin proteoglycan 4 CALCOCO1 PF07888.9 001001632.1_49822001_3 - 0.66 8.3 44.3 0.89 7.9 44.3 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Lebercilin PF15619.4 001001632.1_49822001_3 - 0.92 9.0 52.5 0.39 10.2 16.1 3.5 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease MscS_porin PF12795.5 001001632.1_49822001_3 - 1.1 8.6 38.9 3.9 6.8 28.8 3.0 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Fib_alpha PF08702.8 001001632.1_49822001_3 - 1.1 9.3 24.7 0.53 10.3 8.1 2.5 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Alanine_zipper PF11839.6 001001632.1_49822001_3 - 1.1 9.4 33.6 2 8.6 5.3 4.4 1 1 2 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein SNARE PF05739.17 001001632.1_49822001_3 - 1.2 9.0 7.2 1.4 8.8 0.1 3.5 4 0 0 4 4 3 0 SNARE domain Snapin_Pallidin PF14712.4 001001632.1_49822001_3 - 2.1 8.7 27.9 1.4 9.2 3.2 4.7 2 1 3 5 5 5 0 Snapin/Pallidin APG6 PF04111.10 001001632.1_49822001_3 - 2.4 7.4 44.3 2.5 7.3 21.8 2.2 1 1 1 2 2 2 0 Autophagy protein Apg6 XhlA PF10779.7 001001632.1_49822001_3 - 2.5 8.2 36.9 2.3 8.3 1.0 5.1 3 1 2 5 5 5 0 Haemolysin XhlA ADIP PF11559.6 001001632.1_49822001_3 - 4 7.4 41.4 0.077 12.9 8.5 3.5 1 1 4 5 5 3 0 Afadin- and alpha -actinin-Binding HR1 PF02185.14 001001632.1_49822001_3 - 5.8 7.0 34.8 0.22 11.5 12.3 4.9 1 1 1 3 3 3 0 Hr1 repeat V_ATPase_I PF01496.17 001001632.1_49822001_3 - 5.8 4.5 32.7 1.3 6.7 8.0 2.0 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Exonuc_VII_L PF02601.13 001001632.1_49822001_3 - 6.8 6.0 30.0 4.8 6.5 15.8 2.1 1 1 1 2 2 2 0 Exonuclease VII, large subunit Fmp27_WPPW PF10359.7 001001632.1_49822001_3 - 7.2 5.2 32.4 0.97 8.1 12.8 2.3 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain NPV_P10 PF05531.10 001001632.1_49822001_3 - 7.5 7.0 13.2 2.5 8.5 0.7 3.9 2 2 0 3 3 3 0 Nucleopolyhedrovirus P10 protein HrpB7 PF09486.8 001001632.1_49822001_3 - 7.9 6.7 50.3 3.8 7.7 0.9 4.5 1 1 1 4 4 4 0 Bacterial type III secretion protein (HrpB7) DUF3450 PF11932.6 001001632.1_49822001_3 - 8.7 5.4 39.6 0.28 10.3 10.0 3.1 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) IncA PF04156.12 001001632.1_49822001_3 - 9.8 5.8 53.6 1.6e+04 -21.3 53.7 3.4 1 1 0 1 1 0 0 IncA protein DUF2464 PF10240.7 199375.1_45723001_2 - 4.9e-62 209.5 0.0 5.9e-62 209.3 0.0 1.1 1 0 0 1 1 1 1 Multivesicular body subunit 12 DNA_mis_repair PF01119.17 001009535.1_45727001_1 - 1.8e-26 92.0 0.8 6.3e-26 90.3 0.0 2.2 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HMG_box PF00505.17 001009535.1_45727001_1 - 5.4e-15 55.4 2.8 1.2e-14 54.3 2.8 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 001009535.1_45727001_1 - 3.8e-12 46.5 3.3 8.4e-12 45.4 3.3 1.5 1 0 0 1 1 1 1 HMG-box domain HATPase_c_3 PF13589.4 001009535.1_45727001_1 - 2.6e-10 40.1 0.1 2.6e-10 40.1 0.1 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.24 001009535.1_45727001_1 - 5.4e-07 30.0 0.1 1.2e-06 28.9 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase NIPSNAP PF07978.11 001009422.1_45723001_2 - 1.6e-57 191.9 2.1 2.3e-29 101.5 0.5 2.1 2 0 0 2 2 2 2 NIPSNAP 7tm_1 PF00001.19 001013017.1_39723001_1 - 1.5e-44 152.1 15.5 2.2e-44 151.6 15.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001013017.1_39723001_1 - 3.6e-13 49.4 16.3 5.1e-13 48.9 16.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001013017.1_39723001_1 - 1.4e-09 38.0 15.6 3.4e-05 23.6 8.1 2.7 2 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srv PF10323.7 001013017.1_39723001_1 - 8e-07 28.6 11.0 1.5e-06 27.6 11.0 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.7 001013017.1_39723001_1 - 7.2e-05 22.1 9.7 7.2e-05 22.1 9.7 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx YlaC PF10777.7 001013017.1_39723001_1 - 0.018 14.8 1.2 0.15 11.8 0.2 2.5 2 0 0 2 2 2 0 Inner membrane protein YlaC DUF1211 PF06736.9 001013017.1_39723001_1 - 6.7 7.1 8.7 0.45 10.9 2.1 2.5 3 1 0 3 3 3 0 Protein of unknown function (DUF1211) Kelch_1 PF01344.23 057191.1_45725001_1 - 7.2e-44 147.0 0.0 9e-10 37.9 0.0 5.6 6 0 0 6 6 6 5 Kelch motif BACK PF07707.13 057191.1_45725001_1 - 4.6e-32 110.1 1.7 9.3e-32 109.1 1.7 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_6 PF13964.4 057191.1_45725001_1 - 3.1e-31 106.5 0.1 2.1e-09 37.2 0.0 5.4 2 1 3 5 5 5 5 Kelch motif BTB PF00651.29 057191.1_45725001_1 - 7.6e-29 100.0 0.3 2.7e-28 98.3 0.3 1.9 2 0 0 2 2 2 1 BTB/POZ domain Kelch_4 PF13418.4 057191.1_45725001_1 - 3.7e-23 81.1 0.0 1.6e-05 24.6 0.0 5.4 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.4 057191.1_45725001_1 - 7.2e-19 67.4 0.0 0.0071 16.5 0.0 5.4 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_2 PF07646.13 057191.1_45725001_1 - 2e-17 62.2 1.1 0.037 13.9 0.0 5.6 4 1 1 5 5 5 5 Kelch motif Kelch_5 PF13854.4 057191.1_45725001_1 - 3.1e-13 49.2 0.0 0.11 12.4 0.0 5.4 5 0 0 5 5 5 3 Kelch motif DUF3342 PF11822.6 057191.1_45725001_1 - 0.00029 20.8 2.3 0.0079 16.2 0.0 3.1 2 1 1 3 3 3 1 Domain of unknown function (DUF3342) Neurexophilin PF06312.10 001025055.1_45726001_3 - 1.1e-22 80.5 0.0 2e-22 79.6 0.0 1.3 1 0 0 1 1 1 1 Neurexophilin Filamin PF00630.17 001025055.1_45726001_3 - 0.002 18.8 0.0 0.0041 17.8 0.0 1.4 1 0 0 1 1 1 1 Filamin/ABP280 repeat Nuc_deoxyrib_tr PF05014.13 133525.1_45722001_3 - 2.7e-18 66.1 0.0 3.3e-18 65.8 0.0 1.1 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase Nuc_deoxyri_tr2 PF15891.3 133525.1_45722001_3 - 0.095 12.9 0.0 0.19 11.9 0.0 1.6 1 1 0 1 1 1 0 Nucleoside 2-deoxyribosyltransferase like Glyco_trans_1_4 PF13692.4 133525.1_45722001_3 - 0.13 12.5 0.0 0.2 11.9 0.0 1.4 1 1 0 1 1 1 0 Glycosyl transferases group 1 DSPc PF00782.18 001012352.1_45724001_1 - 2.4e-30 104.9 0.0 4e-30 104.2 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 001012352.1_45724001_1 - 0.0028 17.1 0.0 0.0044 16.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.10 001012352.1_45724001_1 - 0.027 14.6 0.0 0.055 13.6 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain PTR2 PF00854.19 139341.1_45724001_3 - 1.6e-76 257.6 1.5 1.1e-75 254.8 2.6 1.8 2 0 0 2 2 2 1 POT family MFS_1 PF07690.14 139341.1_45724001_3 - 5.1e-06 25.5 31.7 3.4e-05 22.8 30.9 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Uteroglobin PF01099.15 013051.1_45721001_1 - 2.3e-20 72.4 0.0 3.9e-20 71.7 0.0 1.4 1 0 0 1 1 1 1 Uteroglobin family TMEM132 PF16070.3 198727.1_45727001_2 - 2e-147 490.9 1.7 2.6e-147 490.5 1.7 1.2 1 0 0 1 1 1 1 Transmembrane protein family 132 TMEM132D_N PF15705.3 198727.1_45727001_2 - 1.9e-57 192.6 0.1 4.8e-57 191.3 0.1 1.8 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, N-term TMEM132D_C PF15706.3 198727.1_45727001_2 - 1.6e-33 114.2 0.0 3.4e-33 113.1 0.0 1.6 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term ABC_tran PF00005.25 001042379.1_39725001_1 - 2.3e-43 147.8 13.6 1.7e-22 80.3 0.0 4.4 5 0 0 5 5 4 2 ABC transporter AAA_21 PF13304.4 001042379.1_39725001_1 - 1.3e-14 54.6 3.9 0.0016 18.2 0.0 4.7 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.17 001042379.1_39725001_1 - 2.8e-09 36.6 8.3 0.00033 20.0 0.0 4.6 3 2 1 4 4 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.4 001042379.1_39725001_1 - 1e-06 28.2 0.0 0.0032 17.0 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_18 PF13238.4 001042379.1_39725001_1 - 1.4e-06 28.8 6.3 0.0022 18.3 0.0 4.9 3 2 0 4 4 4 1 AAA domain AAA_16 PF13191.4 001042379.1_39725001_1 - 4.3e-06 27.1 0.1 0.12 12.6 0.1 2.9 2 0 0 2 2 2 2 AAA ATPase domain NACHT PF05729.10 001042379.1_39725001_1 - 7.1e-06 25.9 0.0 0.05 13.4 0.0 2.6 2 0 0 2 2 2 2 NACHT domain DUF258 PF03193.14 001042379.1_39725001_1 - 1.5e-05 24.8 3.0 0.016 14.9 0.0 3.0 3 0 0 3 3 2 2 Protein of unknown function, DUF258 AAA_24 PF13479.4 001042379.1_39725001_1 - 1.6e-05 24.6 0.0 0.22 11.1 0.0 3.1 2 0 0 2 2 2 2 AAA domain ABC_tran_Xtn PF12848.5 001042379.1_39725001_1 - 1.9e-05 24.4 16.4 1.9e-05 24.4 16.4 5.2 4 1 0 4 4 2 1 ABC transporter AAA_14 PF13173.4 001042379.1_39725001_1 - 2.8e-05 24.0 0.1 0.14 12.0 0.0 3.3 3 0 0 3 3 2 2 AAA domain AAA PF00004.27 001042379.1_39725001_1 - 2.8e-05 24.4 0.5 0.12 12.6 0.0 3.4 3 1 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.4 001042379.1_39725001_1 - 7.9e-05 23.1 0.1 0.0011 19.4 0.0 5.7 5 1 0 5 5 3 2 AAA domain AAA_28 PF13521.4 001042379.1_39725001_1 - 0.00013 22.1 6.2 0.097 12.8 0.1 3.3 3 0 0 3 3 2 2 AAA domain RNA_helicase PF00910.20 001042379.1_39725001_1 - 0.00016 21.9 0.0 0.83 9.9 0.0 2.9 2 0 0 2 2 2 2 RNA helicase MMR_HSR1 PF01926.21 001042379.1_39725001_1 - 0.00018 21.4 1.1 0.052 13.5 0.3 3.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_5 PF07728.12 001042379.1_39725001_1 - 0.0002 21.2 0.4 1.2 8.9 0.1 3.3 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.4 001042379.1_39725001_1 - 0.0005 20.2 5.0 0.21 11.7 0.2 3.7 3 1 0 3 3 3 2 AAA domain Roc PF08477.11 001042379.1_39725001_1 - 0.0014 18.7 0.0 2.1 8.5 0.0 3.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase NTPase_1 PF03266.13 001042379.1_39725001_1 - 0.0016 18.2 0.8 1.9 8.3 0.1 3.1 3 0 0 3 3 3 2 NTPase cobW PF02492.17 001042379.1_39725001_1 - 0.0024 17.4 0.1 0.31 10.5 0.0 2.7 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.4 001042379.1_39725001_1 - 0.0037 16.7 0.8 0.54 9.7 0.0 3.1 2 2 0 2 2 2 1 AAA domain SRP54 PF00448.20 001042379.1_39725001_1 - 0.009 15.5 0.0 1.5 8.3 0.0 2.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain NB-ARC PF00931.20 001042379.1_39725001_1 - 0.014 14.4 1.3 1.2 8.0 0.0 3.1 3 0 0 3 3 3 0 NB-ARC domain IstB_IS21 PF01695.15 001042379.1_39725001_1 - 0.019 14.6 0.0 3.9 7.1 0.0 2.8 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_33 PF13671.4 001042379.1_39725001_1 - 0.045 13.8 7.3 1.1 9.3 0.0 3.4 4 0 0 4 4 2 0 AAA domain PduV-EutP PF10662.7 001042379.1_39725001_1 - 0.06 13.0 0.1 7.5 6.2 0.0 3.2 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_19 PF13245.4 001042379.1_39725001_1 - 0.087 13.0 0.2 3.9 7.7 0.1 2.9 2 1 0 2 2 2 0 AAA domain DUF4845 PF16137.3 001042379.1_39725001_1 - 0.88 10.4 4.7 41 5.0 0.0 3.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4845) ATPase_2 PF01637.16 001042379.1_39725001_1 - 1.2 8.9 0.0 1.2 8.9 0.0 4.1 5 0 0 5 5 3 0 ATPase domain predominantly from Archaea Pkinase PF00069.23 053887.1_45729001_3 - 1.7e-65 220.9 0.0 2.4e-65 220.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 053887.1_45729001_3 - 1.7e-38 132.3 0.0 3.5e-38 131.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 053887.1_45729001_3 - 4.9e-08 32.5 0.0 0.00011 21.4 0.0 2.3 2 0 0 2 2 2 2 Kinase-like zf-RING_2 PF13639.4 053887.1_45729001_3 - 7.7e-06 25.9 11.9 2.2e-05 24.5 11.9 1.9 1 0 0 1 1 1 1 Ring finger domain APH PF01636.21 053887.1_45729001_3 - 0.018 14.9 0.0 0.044 13.6 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family PHD PF00628.27 053887.1_45729001_3 - 0.026 14.3 8.8 0.061 13.1 8.8 1.7 1 0 0 1 1 1 0 PHD-finger Phostensin_N PF13916.4 053887.1_45729001_3 - 0.073 13.3 0.3 0.23 11.7 0.3 1.9 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal FANCL_C PF11793.6 053887.1_45729001_3 - 0.16 12.1 7.7 0.41 10.7 7.7 1.7 1 0 0 1 1 1 0 FANCL C-terminal domain zf-ANAPC11 PF12861.5 053887.1_45729001_3 - 0.2 11.6 4.3 0.45 10.5 4.3 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Di19 PF05605.10 053887.1_45729001_3 - 1.7 8.9 6.2 6.9 6.9 2.3 2.5 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-rbx1 PF12678.5 053887.1_45729001_3 - 2 8.6 10.1 7.8 6.7 10.1 2.1 1 1 0 1 1 1 0 RING-H2 zinc finger domain GlcNAc_2-epim PF07221.9 031095.1_45723001_3 - 2.3e-45 155.2 0.1 2.9e-45 154.9 0.1 1.1 1 0 0 1 1 1 1 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Calc_CGRP_IAPP PF00214.17 213746.1_49822001_1 - 8.6e-43 145.4 0.1 1.2e-42 144.9 0.1 1.2 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family Trefoil PF00088.16 213746.1_49822001_1 - 0.021 14.6 0.6 0.051 13.3 0.6 1.7 1 0 0 1 1 1 0 Trefoil (P-type) domain Exo_endo_phos PF03372.21 001081485.1_39722001_1 - 4.5e-13 49.3 0.0 6e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 001081485.1_39722001_1 - 0.003 17.3 0.0 0.021 14.6 0.0 2.1 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase NDUF_B12 PF08122.10 001076783.1_39721001_1 - 2.1e-23 82.0 2.0 3.9e-23 81.1 2.0 1.5 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family Afaf PF15339.4 001039345.1_45723001_1 - 3.9e-89 297.5 3.2 5.8e-89 297.0 3.2 1.2 1 0 0 1 1 1 1 Acrosome formation-associated factor DUF4576 PF15144.4 001039345.1_45723001_1 - 0.071 12.9 0.4 0.27 11.0 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4576) PWI PF01480.15 005839.3_26228001_3 - 7e-30 103.0 0.2 1.2e-29 102.3 0.2 1.4 1 0 0 1 1 1 1 PWI domain ETRAMP PF09716.8 005839.3_26228001_3 - 0.4 10.6 9.0 0.022 14.7 2.4 2.3 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) MSC PF09402.8 001039032.1_45724001_3 - 8.5e-18 64.8 0.1 1.2e-17 64.4 0.1 1.1 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain Post_transc_reg PF13797.4 001039032.1_45724001_3 - 0.026 14.2 0.8 0.059 13.1 0.8 1.5 1 0 0 1 1 1 0 Post-transcriptional regulator VirB3 PF05101.11 001039032.1_45724001_3 - 0.24 11.5 3.4 0.22 11.7 0.3 2.1 2 0 0 2 2 2 0 Type IV secretory pathway, VirB3-like protein RNase_PH PF01138.19 001025406.1_45724001_1 - 1.3e-22 80.6 0.0 2.1e-22 79.9 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.13 001025406.1_45724001_1 - 1.4e-12 47.3 0.0 5.2e-12 45.5 0.0 2.0 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 LIM PF00412.20 001033916.1_39723001_1 - 2e-32 111.0 24.7 8.4e-18 64.2 1.9 2.2 2 0 0 2 2 2 2 LIM domain Homeobox PF00046.27 001033916.1_39723001_1 - 7e-20 70.5 1.9 1.2e-19 69.7 1.9 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001033916.1_39723001_1 - 1.6e-05 24.5 0.1 4.5e-05 23.1 0.1 1.7 1 0 0 1 1 1 1 Homeobox KN domain Sec23_trunk PF04811.13 001109456.1_45729001_3 - 5e-91 304.5 0.0 6.7e-91 304.0 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.13 001109456.1_45729001_3 - 5.6e-27 93.4 0.1 1e-26 92.6 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.10 001109456.1_45729001_3 - 8.2e-18 64.8 0.0 8.3e-17 61.6 0.0 2.3 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.13 001109456.1_45729001_3 - 1.2e-13 50.7 7.9 2.9e-13 49.5 7.9 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.20 001109456.1_45729001_3 - 6.7e-12 45.0 0.0 1.6e-11 43.8 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat Prefoldin PF02996.15 002624.3_26222001_1 - 1.6e-28 98.9 3.4 3.1e-28 98.0 3.4 1.4 1 0 0 1 1 1 1 Prefoldin subunit DUF1795 PF08786.9 002624.3_26222001_1 - 0.014 15.3 2.7 0.11 12.4 0.1 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF1795) ING PF12998.5 002624.3_26222001_1 - 0.042 14.3 1.2 0.042 14.3 1.2 2.3 3 0 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding eRF1_2 PF03464.13 001082767.1_37925001_1 - 3.3e-46 156.8 0.1 6.5e-46 155.8 0.1 1.5 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.13 001082767.1_37925001_1 - 1.4e-38 131.8 0.3 2.5e-38 130.9 0.3 1.5 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.13 001082767.1_37925001_1 - 1.7e-19 69.9 0.0 2.9e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 Ribosomal_L7Ae PF01248.24 001082767.1_37925001_1 - 0.023 14.3 0.0 0.044 13.4 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PTCB-BRCT PF12738.5 001107844.1_45728001_1 - 5.1e-59 196.0 2.7 3e-21 75.0 0.0 5.0 5 0 0 5 5 5 4 twin BRCT domain BRCT PF00533.24 001107844.1_45728001_1 - 1.6e-52 175.7 1.8 4.3e-12 46.1 0.0 5.8 6 0 0 6 6 6 5 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.3 001107844.1_45728001_1 - 4.5e-32 110.2 0.7 6.9e-08 32.7 0.0 5.9 6 0 0 6 6 6 5 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.3 001107844.1_45728001_1 - 1.5e-27 95.2 0.2 2.3e-20 72.2 0.1 3.9 3 0 0 3 3 3 2 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.3 001107844.1_45728001_1 - 6.1e-16 58.3 2.0 0.00015 21.8 0.0 5.7 5 0 0 5 5 5 3 DNA ligase 3 BRCT domain Bcl-2 PF00452.17 001106459.1_45722001_2 - 0.0009 19.7 0.0 0.0015 18.9 0.0 1.4 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family Lipocalin PF00061.21 001109514.1_45723001_1 - 7.1e-23 81.3 1.0 9.3e-23 80.9 1.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 001109514.1_45723001_1 - 0.024 14.4 0.8 0.035 13.9 0.8 1.2 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family MRP-S24 PF14955.4 001077659.1_45722001_3 - 8.3e-58 194.0 0.0 1.1e-57 193.6 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosome subunit S24 Ras PF00071.20 001082034.1_37922001_1 - 1.6e-57 193.5 0.1 1.9e-57 193.2 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001082034.1_37922001_1 - 3.1e-32 111.2 0.0 5.3e-32 110.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001082034.1_37922001_1 - 7.8e-14 51.4 0.1 9.2e-14 51.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001082034.1_37922001_1 - 2.9e-07 30.4 0.0 5e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001082034.1_37922001_1 - 8.9e-07 28.4 0.0 1.1e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF258 PF03193.14 001082034.1_37922001_1 - 2e-06 27.7 0.3 0.0031 17.3 0.1 2.2 1 1 1 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001082034.1_37922001_1 - 2.5e-06 27.0 0.0 0.00014 21.3 0.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Septin PF00735.16 001082034.1_37922001_1 - 0.0012 18.0 0.2 0.018 14.1 0.1 2.1 2 0 0 2 2 2 1 Septin cobW PF02492.17 001082034.1_37922001_1 - 0.0012 18.3 0.0 0.0051 16.3 0.0 1.8 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.15 001082034.1_37922001_1 - 0.0014 18.3 0.4 0.063 12.9 0.1 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.4 001082034.1_37922001_1 - 0.0026 17.9 0.0 0.0052 16.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.8 001082034.1_37922001_1 - 0.0069 15.7 0.0 0.011 15.1 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.7 001082034.1_37922001_1 - 0.0089 15.6 0.2 0.11 12.1 0.1 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.13 001082034.1_37922001_1 - 0.014 15.2 0.0 0.024 14.4 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_24 PF13479.4 001082034.1_37922001_1 - 0.014 15.0 0.0 0.024 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.12 001082034.1_37922001_1 - 0.018 14.9 0.0 0.031 14.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.4 001082034.1_37922001_1 - 0.018 15.3 0.0 0.055 13.7 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain ATPase_2 PF01637.16 001082034.1_37922001_1 - 0.059 13.1 0.6 0.099 12.4 0.1 1.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea G-alpha PF00503.18 001082034.1_37922001_1 - 0.068 12.2 2.4 0.31 10.0 0.2 2.3 1 1 1 2 2 2 0 G-protein alpha subunit NACHT PF05729.10 001082034.1_37922001_1 - 0.077 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 NACHT domain TniB PF05621.9 001082034.1_37922001_1 - 0.083 11.9 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein RNA_helicase PF00910.20 001082034.1_37922001_1 - 0.098 12.9 0.0 0.3 11.3 0.0 1.9 2 0 0 2 2 2 0 RNA helicase ABC_tran PF00005.25 001082034.1_37922001_1 - 0.15 12.4 0.1 0.44 10.9 0.0 1.8 2 0 0 2 2 2 0 ABC transporter NOA36 PF06524.10 001002855.2_45722001_1 - 8.9e-05 21.9 4.2 0.00014 21.3 4.2 1.2 1 0 0 1 1 1 1 NOA36 protein PBP1_TM PF14812.4 001002855.2_45722001_1 - 0.013 15.8 5.7 0.021 15.1 5.7 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RNA_pol_3_Rpc31 PF11705.6 001002855.2_45722001_1 - 0.025 14.7 9.2 0.034 14.2 9.2 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 CENP-B_dimeris PF09026.8 001002855.2_45722001_1 - 0.03 14.6 15.4 0.056 13.7 15.4 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.10 001002855.2_45722001_1 - 0.039 13.6 7.0 0.043 13.4 7.0 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Nop14 PF04147.10 001002855.2_45722001_1 - 0.063 11.4 9.4 0.06 11.4 9.4 1.0 1 0 0 1 1 1 0 Nop14-like family PTPRCAP PF15713.3 001002855.2_45722001_1 - 0.085 13.0 9.2 0.11 12.7 9.2 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated SDA1 PF05285.10 001002855.2_45722001_1 - 0.1 11.9 8.6 0.11 11.8 8.6 1.1 1 0 0 1 1 1 0 SDA1 RXT2_N PF08595.9 001002855.2_45722001_1 - 0.17 11.8 4.6 0.21 11.5 4.6 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF4724 PF15852.3 001002855.2_45722001_1 - 0.17 12.1 2.8 0.39 11.0 2.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4724) TLP-20 PF06088.9 001002855.2_45722001_1 - 0.19 11.4 1.6 0.23 11.2 1.6 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Pox_Ag35 PF03286.12 001002855.2_45722001_1 - 0.22 11.2 4.9 0.27 10.9 4.9 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FAM176 PF14851.4 001002855.2_45722001_1 - 0.27 10.8 6.0 0.38 10.3 6.0 1.3 1 0 0 1 1 1 0 FAM176 family DUF913 PF06025.10 001002855.2_45722001_1 - 0.74 8.6 2.6 0.8 8.5 2.6 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CDC45 PF02724.12 001002855.2_45722001_1 - 0.76 7.9 7.8 0.81 7.8 7.8 1.0 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.11 001002855.2_45722001_1 - 0.88 7.5 11.8 0.99 7.3 11.8 1.0 1 0 0 1 1 1 0 DNA polymerase phi Radial_spoke PF04712.10 001002855.2_45722001_1 - 1.4 7.7 9.5 1.6 7.4 9.5 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein TRAP_alpha PF03896.14 001002855.2_45722001_1 - 3.4 6.6 5.7 4 6.4 5.7 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Astro_capsid_p PF12226.6 001002855.2_45722001_1 - 5.6 5.9 7.2 7.3 5.5 7.2 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Cytomega_UL84 PF06284.9 001002855.2_45722001_1 - 8.3 4.6 6.6 9.9 4.3 6.6 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein GRIM-19 PF06212.10 001071788.1_39721001_1 - 5.6e-51 171.8 0.0 6.5e-51 171.6 0.0 1.0 1 0 0 1 1 1 1 GRIM-19 protein COX14 PF14880.4 001071788.1_39721001_1 - 0.036 13.8 0.0 0.06 13.1 0.0 1.4 1 0 0 1 1 1 0 Cytochrome oxidase c assembly E1-E2_ATPase PF00122.18 001082027.1_37929001_1 - 2e-55 187.4 7.0 5.6e-55 185.9 7.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 001082027.1_37929001_1 - 1.4e-40 138.8 1.6 1.4e-40 138.8 1.6 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 001082027.1_37929001_1 - 4.9e-25 87.3 0.0 8.8e-25 86.5 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 001082027.1_37929001_1 - 8.8e-19 68.5 0.0 2.8e-16 60.3 0.0 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 001082027.1_37929001_1 - 1.8e-15 56.2 0.0 3.6e-15 55.2 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 001082027.1_37929001_1 - 3e-07 30.3 3.1 0.00021 21.0 1.0 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.5 001082027.1_37929001_1 - 0.097 12.9 0.2 0.5 10.6 0.2 2.0 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase ETC_C1_NDUFA5 PF04716.12 001071797.1_39721001_1 - 2.3e-27 94.5 0.5 3.1e-27 94.0 0.5 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region NACHT PF05729.10 001107474.1_45726001_1 - 6.6e-43 146.4 0.0 2e-42 144.8 0.0 1.9 1 0 0 1 1 1 1 NACHT domain LRR_6 PF13516.4 001107474.1_45726001_1 - 1e-13 50.0 35.5 0.00088 19.0 0.5 10.1 10 0 0 10 10 10 5 Leucine Rich repeat AAA_16 PF13191.4 001107474.1_45726001_1 - 8e-05 22.9 0.3 0.0052 17.1 0.3 2.7 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.27 001107474.1_45726001_1 - 0.0099 16.2 0.0 0.023 15.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 001107474.1_45726001_1 - 0.014 15.5 0.1 0.24 11.6 0.1 3.0 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.4 001107474.1_45726001_1 - 0.015 14.7 0.0 0.031 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain LRR_9 PF14580.4 001107474.1_45726001_1 - 0.1 11.9 0.5 0.34 10.2 0.4 2.0 1 1 0 1 1 1 0 Leucine-rich repeat LRR_4 PF12799.5 001107474.1_45726001_1 - 0.59 10.5 31.4 3.1 8.2 0.9 6.7 4 2 2 7 7 7 0 Leucine Rich repeats (2 copies) zf-CpG_bind_C PF12269.6 001079698.1_45725001_3 - 1.6e-104 348.7 7.9 1.6e-104 348.7 7.9 2.8 4 0 0 4 4 4 1 CpG binding protein zinc finger C terminal domain zf-CXXC PF02008.18 001079698.1_45725001_3 - 1.7e-16 59.8 20.4 1.7e-16 59.8 20.4 3.4 3 0 0 3 3 3 1 CXXC zinc finger domain PHD PF00628.27 001079698.1_45725001_3 - 8.9e-11 41.4 11.9 8.9e-11 41.4 11.9 4.1 4 1 0 4 4 4 1 PHD-finger PHD_2 PF13831.4 001079698.1_45725001_3 - 0.042 13.3 9.9 0.019 14.4 5.4 2.8 2 0 0 2 2 2 0 PHD-finger NARP1 PF12569.6 001079698.1_45725001_3 - 9.1 4.9 13.5 5.8 5.6 6.5 2.3 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 LRR_8 PF13855.4 020862.1_26227001_1 - 4.6e-33 112.7 5.1 4.4e-13 48.6 1.1 3.4 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.5 020862.1_26227001_1 - 1.6e-13 50.4 2.1 0.0016 18.6 0.4 4.5 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) I-set PF07679.14 020862.1_26227001_1 - 1.5e-12 47.3 0.0 2.4e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 020862.1_26227001_1 - 1.6e-12 47.8 0.0 3.3e-12 46.7 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 020862.1_26227001_1 - 2.7e-09 37.0 0.0 6.1e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 020862.1_26227001_1 - 5.2e-08 33.0 0.0 1.4e-07 31.7 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain fn3 PF00041.19 020862.1_26227001_1 - 1.3e-07 31.8 0.0 3.6e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III domain LRR_1 PF00560.31 020862.1_26227001_1 - 0.00036 20.5 3.1 5.4 7.8 0.0 5.8 6 0 0 6 6 5 1 Leucine Rich Repeat LRR_9 PF14580.4 020862.1_26227001_1 - 0.025 14.0 0.1 0.025 14.0 0.1 2.7 2 1 1 3 3 2 0 Leucine-rich repeat CbiM PF01891.14 020862.1_26227001_1 - 0.052 13.2 0.3 0.094 12.4 0.3 1.3 1 0 0 1 1 1 0 Cobalt uptake substrate-specific transmembrane region V-set PF07686.15 020862.1_26227001_1 - 0.092 12.8 0.1 8.7 6.4 0.0 2.6 1 1 1 2 2 2 0 Immunoglobulin V-set domain AP3D1 PF06375.9 020862.1_26227001_1 - 2.1 8.5 18.4 3.2 7.9 18.4 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF4604 PF15377.4 020862.1_26227001_1 - 2.5 8.4 17.7 4.3 7.6 17.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Peptidase_S49_N PF08496.8 020862.1_26227001_1 - 3.7 7.5 12.9 6.3 6.7 12.9 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Cytochrom_C PF00034.19 001071821.1_39721001_1 - 5e-13 49.9 0.0 6.3e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.4 001071821.1_39721001_1 - 6.9e-06 26.2 1.7 1.8e-05 24.8 1.7 1.7 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.4 001071821.1_39721001_1 - 0.00025 20.6 2.7 0.0033 17.0 2.7 2.2 1 1 0 1 1 1 1 Cytochrome c-550 domain Hemopexin PF00045.17 001082292.1_37924001_1 - 1.3e-51 172.1 16.9 8e-15 54.4 0.1 5.2 6 0 0 6 6 6 4 Hemopexin Somatomedin_B PF01033.15 001082292.1_37924001_1 - 2.7e-09 37.1 20.4 5e-09 36.3 20.4 1.5 1 0 0 1 1 1 1 Somatomedin B domain RNA_capsid PF03035.12 001082292.1_37924001_1 - 0.015 15.2 0.5 0.024 14.5 0.5 1.2 1 0 0 1 1 1 0 Calicivirus putative RNA polymerase/capsid protein Peptidase_A22B PF04258.11 001107789.1_45723001_2 - 1.5e-103 346.1 8.0 1.9e-103 345.8 8.0 1.1 1 0 0 1 1 1 1 Signal peptide peptidase SPP PF06550.9 001107789.1_45723001_2 - 1.1e-05 24.9 6.4 2.2e-05 23.9 6.4 1.4 1 0 0 1 1 1 1 Signal-peptide peptidase, presenilin aspartyl protease DUF4345 PF14248.4 001107789.1_45723001_2 - 0.0023 17.7 0.6 0.0023 17.7 0.6 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF4345) Presenilin PF01080.15 001107789.1_45723001_2 - 0.015 14.0 6.7 0.0094 14.6 4.9 1.5 1 1 1 2 2 2 0 Presenilin Ribosomal_L2 PF00181.21 001034136.1_45723001_1 - 3.4e-29 100.5 0.1 1.3e-28 98.6 0.1 2.0 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain Ribosomal_L2_C PF03947.16 001034136.1_45723001_1 - 1.1e-28 99.8 0.3 3.4e-28 98.2 0.3 1.8 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain HAUS-augmin3 PF14932.4 001100869.1_45724001_2 - 0.0029 17.1 7.0 0.0029 17.1 7.0 3.8 1 1 3 4 4 4 1 HAUS augmin-like complex subunit 3 DUF1136 PF06582.10 001100869.1_45724001_2 - 0.13 12.1 2.5 0.66 9.8 2.5 2.3 1 0 0 1 1 1 0 Repeat of unknown function (DUF1136) Kinesin PF00225.21 001106529.1_45729001_1 - 2.1e-121 404.8 0.3 2.1e-121 404.8 0.3 1.7 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.3 001106529.1_45729001_1 - 3.9e-28 98.2 0.0 8.1e-28 97.1 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding Kinesin_assoc PF16183.3 001106529.1_45729001_1 - 0.062 13.3 0.1 0.062 13.3 0.1 2.5 2 0 0 2 2 2 0 Kinesin-associated DUF948 PF06103.9 001106529.1_45729001_1 - 1.6 8.9 6.5 1.1 9.4 3.3 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) AF-4 PF05110.11 001107001.1_45729001_2 - 0 1352.6 137.7 0 1352.4 137.7 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein FMO-like PF00743.17 001082246.1_37926001_3 - 2.4e-284 943.5 0.0 2.8e-284 943.3 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.4 001082246.1_37926001_3 - 6.3e-15 55.1 0.0 1.3e-10 40.9 0.0 2.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.12 001082246.1_37926001_3 - 2.2e-11 43.4 0.0 2.1e-10 40.2 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.4 001082246.1_37926001_3 - 5e-08 32.3 0.2 6.5e-06 25.4 0.0 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.4 001082246.1_37926001_3 - 9.4e-06 25.7 0.0 3.2e-05 23.9 0.0 1.9 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.25 001082246.1_37926001_3 - 3.8e-05 24.0 0.1 0.047 14.1 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 001082246.1_37926001_3 - 0.00015 21.4 0.0 0.3 10.5 0.0 3.4 4 0 0 4 4 4 1 FAD dependent oxidoreductase IlvN PF07991.10 001082246.1_37926001_3 - 0.0051 16.3 0.0 0.29 10.6 0.0 2.2 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.18 001082246.1_37926001_3 - 0.0081 16.1 0.1 0.15 12.0 0.0 2.2 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_9 PF13454.4 001082246.1_37926001_3 - 0.037 13.9 0.0 4.9 7.0 0.0 3.4 3 1 0 3 3 3 0 FAD-NAD(P)-binding NAD_binding_7 PF13241.4 001082246.1_37926001_3 - 0.067 13.5 0.0 3.2 8.1 0.0 2.3 2 0 0 2 2 2 0 Putative NAD(P)-binding USP8_dimer PF08969.9 001082246.1_37926001_3 - 0.18 11.8 0.1 0.33 11.0 0.1 1.3 1 0 0 1 1 1 0 USP8 dimerisation domain Molybdopterin PF00384.20 001079915.1_39725001_1 - 1.2e-75 254.9 0.0 5.2e-75 252.9 0.0 1.8 1 1 0 1 1 1 1 Molybdopterin oxidoreductase Fer2_4 PF13510.4 001079915.1_39725001_1 - 1e-17 63.8 0.3 2.6e-17 62.5 0.3 1.8 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH-G_4Fe-4S_3 PF10588.7 001079915.1_39725001_1 - 3.7e-17 61.5 0.2 9e-17 60.2 0.2 1.7 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region NADH_dhqG_C PF09326.9 001079915.1_39725001_1 - 1.2e-16 61.0 0.0 2.7e-16 59.9 0.0 1.6 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal Fer2 PF00111.25 001079915.1_39725001_1 - 1.7e-09 37.3 1.1 1.7e-09 37.3 1.1 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain TPP_enzyme_M PF00205.20 001079915.1_39725001_1 - 0.028 14.0 0.3 6 6.5 0.1 2.6 2 1 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Fer4 PF00037.25 001079915.1_39725001_1 - 0.36 10.6 2.4 15 5.5 0.4 2.7 2 0 0 2 2 2 0 4Fe-4S binding domain EST1_DNA_bind PF10373.7 001105808.1_45729001_3 - 5.4e-64 216.3 0.1 1e-63 215.4 0.1 1.5 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain PIN_4 PF13638.4 001105808.1_45729001_3 - 2.2e-23 82.9 1.3 7.3e-22 77.9 0.0 2.8 2 0 0 2 2 2 1 PIN domain EST1 PF10374.7 001105808.1_45729001_3 - 1.1e-13 51.9 0.3 3.3e-13 50.3 0.3 1.9 1 0 0 1 1 1 1 Telomerase activating protein Est1 DUF1899 PF08953.9 001109327.2_45723001_1 - 4.4e-32 109.6 0.0 8.2e-32 108.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.3 001109327.2_45723001_1 - 4.8e-22 77.4 0.1 8.6e-22 76.6 0.1 1.4 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.30 001109327.2_45723001_1 - 4.6e-15 55.6 8.5 3.1e-05 24.5 0.6 4.5 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001109327.2_45723001_1 - 2.4e-06 27.6 0.7 0.036 14.2 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 001109327.2_45723001_1 - 0.0033 17.2 0.0 0.0086 15.8 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A PALB2_WD40 PF16756.3 001109327.2_45723001_1 - 0.067 12.0 0.0 0.11 11.3 0.0 1.4 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain Resistin PF06954.9 001109327.2_45723001_2 - 0.045 14.2 1.5 0.045 14.2 1.5 2.3 2 0 0 2 2 2 0 Resistin Kinesin PF00225.21 001039019.1_45727001_3 - 4.9e-110 367.4 0.0 6.2e-110 367.1 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 001039019.1_45727001_3 - 5.7e-27 94.4 0.0 1.1e-26 93.4 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding SlyX PF04102.10 001039019.1_45727001_3 - 0.15 12.6 3.2 0.16 12.5 0.9 2.3 2 0 0 2 2 2 0 SlyX MIF4G PF02854.17 001017374.2_45729001_2 - 1.4e-57 194.7 2.3 2.9e-57 193.6 2.3 1.6 1 0 0 1 1 1 1 MIF4G domain W2 PF02020.16 001017374.2_45729001_2 - 6.2e-20 71.0 1.2 1.9e-19 69.4 1.2 1.9 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon MA3 PF02847.15 001017374.2_45729001_2 - 6.8e-17 61.4 0.2 6.8e-17 61.4 0.2 2.6 3 0 0 3 3 3 1 MA3 domain Ras PF00071.20 001098545.1_39724001_3 - 4e-56 188.9 0.3 5.7e-56 188.5 0.3 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001098545.1_39724001_3 - 1.1e-19 70.6 0.0 1.9e-19 69.9 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001098545.1_39724001_3 - 9.3e-08 31.6 0.1 1.3e-07 31.1 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001098545.1_39724001_3 - 0.0011 18.4 0.1 0.0019 17.6 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001098545.1_39724001_3 - 0.0074 16.2 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001098545.1_39724001_3 - 0.047 13.5 2.1 5.2 6.8 0.0 2.2 1 1 0 2 2 2 0 Protein of unknown function, DUF258 Trypsin PF00089.24 001082016.1_37923001_2 - 2.2e-70 236.8 0.1 2.9e-70 236.4 0.1 1.2 1 0 0 1 1 1 1 Trypsin Gla PF00594.18 001082016.1_37923001_2 - 5.6e-21 74.3 11.6 1.2e-20 73.2 11.6 1.6 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FXa_inhibition PF14670.4 001082016.1_37923001_2 - 4.2e-11 42.8 30.7 2.6e-09 37.0 11.2 2.7 2 0 0 2 2 2 2 Coagulation Factor Xa inhibitory site EGF PF00008.25 001082016.1_37923001_2 - 1.1e-10 41.4 21.3 5.7e-09 36.0 9.2 3.1 2 0 0 2 2 2 2 EGF-like domain Trypsin_2 PF13365.4 001082016.1_37923001_2 - 1.1e-06 29.4 0.0 2.4e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain cEGF PF12662.5 001082016.1_37923001_2 - 0.00014 21.5 1.3 0.00014 21.5 1.3 3.5 4 0 0 4 4 4 2 Complement Clr-like EGF-like DUF1986 PF09342.9 001082016.1_37923001_2 - 0.00077 19.7 0.0 0.0014 18.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) hEGF PF12661.5 001082016.1_37923001_2 - 0.0022 18.4 17.6 0.0031 18.0 6.1 3.7 3 0 0 3 3 2 2 Human growth factor-like EGF EGF_2 PF07974.11 001082016.1_37923001_2 - 0.017 15.3 13.2 0.017 15.3 13.2 3.4 3 0 0 3 3 2 0 EGF-like domain EGF_3 PF12947.5 001082016.1_37923001_2 - 0.029 14.4 28.5 0.14 12.2 10.1 2.6 2 0 0 2 2 2 0 EGF domain Plasmod_Pvs28 PF06247.9 001082016.1_37923001_2 - 0.083 13.1 22.8 0.46 10.7 8.1 2.6 2 0 0 2 2 2 0 Pvs28 EGF domain EGF_CA PF07645.13 001082016.1_37923001_2 - 0.84 9.8 28.4 0.067 13.3 11.7 3.1 2 1 1 3 3 3 0 Calcium-binding EGF domain Peptidase_C1 PF00112.21 001034110.1_45724001_2 - 1.4e-69 234.4 0.9 2.2e-69 233.8 0.9 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 001034110.1_45724001_2 - 3.5e-11 43.2 0.3 7.9e-11 42.1 0.3 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 001034110.1_45724001_2 - 0.00012 20.9 0.7 0.0027 16.4 0.1 2.2 2 0 0 2 2 2 2 Peptidase C1-like family Kunitz_BPTI PF00014.21 001101714.1_37923001_1 - 1.6e-53 178.6 39.0 1.1e-18 67.1 6.5 3.2 3 0 0 3 3 3 3 Kunitz/Bovine pancreatic trypsin inhibitor domain Sushi PF00084.18 001105982.1_45725001_3 - 4e-33 113.7 17.8 1.8e-09 37.9 0.2 4.3 4 0 0 4 4 4 4 Sushi repeat (SCR repeat) MoeA_C PF03454.13 001105982.1_45725001_3 - 0.045 13.8 0.0 0.31 11.1 0.0 2.4 3 0 0 3 3 3 0 MoeA C-terminal region (domain IV) HRM PF02793.20 001105982.1_45725001_3 - 0.23 11.6 3.6 10 6.4 0.1 3.1 3 0 0 3 3 3 0 Hormone receptor domain cEGF PF12662.5 001105982.1_45725001_3 - 1.7 8.5 10.1 15 5.5 0.1 4.6 4 0 0 4 4 4 0 Complement Clr-like EGF-like SSB PF00436.23 001082131.1_37922001_1 - 2.8e-32 110.7 0.3 4e-32 110.2 0.3 1.2 1 0 0 1 1 1 1 Single-strand binding protein family zf-H2C2_2 PF13465.4 001109224.1_45725001_1 - 2.2e-27 94.1 51.9 6.7e-06 26.2 0.2 7.6 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.24 001109224.1_45725001_1 - 5.2e-26 89.5 53.9 5e-05 23.4 0.9 6.7 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001109224.1_45725001_1 - 7.4e-16 57.4 54.3 0.0091 16.6 2.8 7.2 7 0 0 7 7 6 6 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001109224.1_45725001_1 - 1.4e-05 24.8 39.9 0.032 14.1 2.3 6.2 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001109224.1_45725001_1 - 0.00022 21.3 37.6 0.59 10.4 1.4 6.6 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 001109224.1_45725001_1 - 0.021 14.8 24.0 0.38 10.8 3.1 4.6 3 1 1 4 4 4 0 Zinc ribbon domain zinc_ribbon_15 PF17032.3 001109224.1_45725001_1 - 0.026 15.1 15.9 2.4 8.8 0.5 3.8 2 1 1 3 3 3 0 zinc-ribbon family zf-met PF12874.5 001109224.1_45725001_1 - 0.083 13.2 30.8 1.7 9.0 0.2 6.6 6 0 0 6 6 6 0 Zinc-finger of C2H2 type zf-Di19 PF05605.10 001109224.1_45725001_1 - 0.093 12.9 30.7 0.31 11.2 0.3 4.3 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding HypA PF01155.17 001109224.1_45725001_1 - 0.36 10.7 15.4 16 5.4 3.8 3.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-Sec23_Sec24 PF04810.13 001109224.1_45725001_1 - 1.7 8.6 28.5 0.65 10.0 2.1 5.8 4 3 2 6 6 6 0 Sec23/Sec24 zinc finger GAGA PF09237.9 001109224.1_45725001_1 - 4.4 7.1 10.8 28 4.5 0.0 4.3 2 2 2 4 4 4 0 GAGA factor Rep_fac-A_C PF08646.8 001109224.1_45725001_1 - 4.5 6.9 11.1 2.8 7.5 0.6 2.7 2 1 0 3 3 3 0 Replication factor-A C terminal domain zf-C2H2_11 PF16622.3 001109224.1_45725001_1 - 4.8 6.9 16.7 2.2 8.0 0.2 4.5 4 0 0 4 4 4 0 zinc-finger C2H2-type TMIE PF16038.3 001109299.1_45726001_1 - 2.4e-33 113.7 0.7 4.4e-33 112.9 0.7 1.4 1 0 0 1 1 1 1 TMIE protein MACPF PF01823.17 001082346.1_37925001_1 - 2.4e-33 115.9 0.6 2.4e-33 115.9 0.6 1.5 2 0 0 2 2 2 1 MAC/Perforin domain Ldl_recept_a PF00057.16 001082346.1_37925001_1 - 1.5e-11 44.2 14.3 1.5e-11 44.2 14.3 2.3 1 1 1 2 2 2 1 Low-density lipoprotein receptor domain class A TSP_1 PF00090.17 001082346.1_37925001_1 - 9.1e-05 22.5 2.3 9.1e-05 22.5 2.3 2.8 3 0 0 3 3 3 1 Thrombospondin type 1 domain P21-Arc PF04062.12 001034271.2_06522001_2 - 1.4e-81 272.6 0.2 1.6e-81 272.3 0.2 1.1 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit UNC45-central PF11701.6 001037647.1_45727001_2 - 7.4e-39 133.0 4.1 3.3e-35 121.1 0.0 4.7 4 0 0 4 4 4 1 Myosin-binding striated muscle assembly central TPR_2 PF07719.15 001037647.1_45727001_2 - 6.1e-13 47.7 13.3 0.00026 20.7 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.26 001037647.1_45727001_2 - 4.5e-11 42.0 10.9 0.0029 17.2 0.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.4 001037647.1_45727001_2 - 1.9e-08 34.7 5.0 2.9e-06 27.7 0.1 3.7 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 001037647.1_45727001_2 - 2.9e-07 30.1 10.3 0.00014 21.7 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.4 001037647.1_45727001_2 - 8e-07 29.2 1.2 0.039 14.7 0.0 4.8 2 1 2 4 4 4 2 Tetratricopeptide repeat HEAT_2 PF13646.4 001037647.1_45727001_2 - 3.8e-06 27.1 9.7 0.22 11.8 0.1 6.3 5 1 1 6 6 6 2 HEAT repeats TPR_11 PF13414.4 001037647.1_45727001_2 - 1.5e-05 24.5 3.8 0.00019 20.9 0.1 3.0 3 0 0 3 3 3 1 TPR repeat TPR_19 PF14559.4 001037647.1_45727001_2 - 6e-05 23.3 3.3 0.021 15.2 0.3 2.9 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.4 001037647.1_45727001_2 - 0.00012 22.1 4.3 0.0022 18.1 1.4 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.4 001037647.1_45727001_2 - 0.00021 21.3 0.4 1 9.4 0.1 3.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.4 001037647.1_45727001_2 - 0.00038 20.5 0.6 0.08 13.2 0.0 3.2 3 0 0 3 3 2 1 Tetratricopeptide repeat ANAPC3 PF12895.5 001037647.1_45727001_2 - 0.0015 18.6 1.4 0.0057 16.7 1.4 2.1 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 Arm PF00514.21 001037647.1_45727001_2 - 0.0057 16.5 12.1 3.1 7.9 0.0 7.3 9 0 0 9 9 9 1 Armadillo/beta-catenin-like repeat TPR_7 PF13176.4 001037647.1_45727001_2 - 0.024 14.5 5.5 0.17 11.9 0.0 4.0 4 0 0 4 4 3 0 Tetratricopeptide repeat RIX1 PF08167.10 001037647.1_45727001_2 - 0.034 13.8 2.2 0.49 10.0 0.1 2.8 2 0 0 2 2 2 0 rRNA processing/ribosome biogenesis Fis1_TPR_C PF14853.4 001037647.1_45727001_2 - 0.15 12.0 0.7 8.4 6.4 0.0 3.0 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.4 001037647.1_45727001_2 - 0.48 11.0 8.2 0.54 10.9 0.1 4.4 5 0 0 5 5 3 0 Tetratricopeptide repeat BRICHOS PF04089.12 001098547.1_39724001_1 - 4.2e-20 71.5 0.0 7e-20 70.8 0.0 1.4 1 0 0 1 1 1 1 BRICHOS domain SWIB PF02201.16 001108752.1_45727001_3 - 3e-24 84.5 0.2 5.6e-24 83.7 0.2 1.5 1 0 0 1 1 1 1 SWIB/MDM2 domain BRO1 PF03097.16 001025669.1_45727001_2 - 5.3e-41 140.6 0.2 9.6e-41 139.7 0.2 1.3 1 0 0 1 1 1 1 BRO1-like domain Branch PF02485.19 001001511.2_45729001_1 - 5.2e-58 196.3 0.0 7.3e-58 195.8 0.0 1.2 1 0 0 1 1 1 1 Core-2/I-Branching enzyme ARL6IP6 PF15062.4 001001511.2_45729001_1 - 0.069 13.2 0.1 12 6.0 0.0 2.7 2 0 0 2 2 2 0 Haemopoietic lineage transmembrane helix SSF PF00474.15 001082669.1_37925001_1 - 4.7e-163 542.7 19.3 6.1e-163 542.3 19.3 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family 7tm_1 PF00001.19 001106640.1_45725001_1 - 9.8e-47 159.3 22.2 9.8e-47 159.3 22.2 2.3 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001106640.1_45725001_1 - 1.7e-06 27.5 24.4 1.7e-06 27.5 24.4 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx FMO-like PF00743.17 001082245.1_37925001_3 - 6e-279 925.7 0.0 7e-279 925.5 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.4 001082245.1_37925001_3 - 5.8e-19 68.3 0.0 3.1e-14 52.8 0.0 2.4 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.4 001082245.1_37925001_3 - 2.4e-10 40.0 0.0 9.2e-06 24.9 0.0 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.12 001082245.1_37925001_3 - 7.4e-10 38.4 0.0 1.2e-08 34.5 0.0 2.4 1 1 2 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.4 001082245.1_37925001_3 - 3.2e-06 27.1 0.0 8.8e-06 25.8 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 001082245.1_37925001_3 - 4.6e-05 23.1 0.1 0.083 12.4 0.0 3.1 3 0 0 3 3 3 2 FAD dependent oxidoreductase Pyr_redox PF00070.25 001082245.1_37925001_3 - 0.0093 16.4 0.7 2.4 8.7 0.1 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.17 001082245.1_37925001_3 - 0.016 14.4 0.2 1.3 8.2 0.0 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain HI0933_like PF03486.12 001082245.1_37925001_3 - 0.042 12.4 0.1 0.23 10.0 0.1 2.0 2 0 0 2 2 2 0 HI0933-like protein IlvN PF07991.10 001082245.1_37925001_3 - 0.057 12.8 0.0 14 5.0 0.0 2.7 3 0 0 3 3 3 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Thi4 PF01946.15 001082245.1_37925001_3 - 0.061 12.4 0.0 0.68 9.0 0.0 2.1 2 0 0 2 2 2 0 Thi4 family NAD_binding_9 PF13454.4 001082245.1_37925001_3 - 0.063 13.2 0.0 5.1 6.9 0.0 3.3 2 1 0 2 2 2 0 FAD-NAD(P)-binding ELFV_dehydrog PF00208.19 001082245.1_37925001_3 - 0.12 11.9 0.3 15 5.0 0.0 2.7 3 0 0 3 3 3 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase LIM PF00412.20 001106571.1_45724001_3 - 4.8e-31 106.6 21.3 2e-15 56.6 10.1 2.3 2 0 0 2 2 2 2 LIM domain Homeobox PF00046.27 001106571.1_45724001_3 - 7e-19 67.3 3.4 1.4e-18 66.3 3.4 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001106571.1_45724001_3 - 2.5e-05 23.9 5.0 0.00022 20.9 5.0 2.2 1 1 0 1 1 1 1 Homeobox KN domain DUF1314 PF07013.9 001106571.1_45724001_3 - 0.0018 18.0 0.1 0.0034 17.1 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1314) Homez PF11569.6 001106571.1_45724001_3 - 0.012 14.9 0.0 0.027 13.8 0.0 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez TNFR_c6 PF00020.16 001106571.1_45724001_3 - 3.8 7.9 14.4 17 5.8 0.2 3.6 3 0 0 3 3 3 0 TNFR/NGFR cysteine-rich region Fer4_6 PF12837.5 001079887.1_45724001_1 - 0.063 13.3 1.2 0.2 11.7 1.2 1.9 1 0 0 1 1 1 0 4Fe-4S binding domain ING PF12998.5 001079887.1_45724001_2 - 5.1e-32 110.4 3.4 5.1e-32 110.4 3.4 1.6 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.27 001079887.1_45724001_2 - 5.7e-06 26.0 7.6 1.1e-05 25.1 7.6 1.5 1 0 0 1 1 1 1 PHD-finger Spc7 PF08317.9 001079887.1_45724001_2 - 0.016 14.0 9.4 0.021 13.6 9.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein zf-HC5HC2H PF13771.4 001079887.1_45724001_2 - 0.022 14.8 0.0 0.045 13.9 0.0 1.4 1 0 0 1 1 1 0 PHD-like zinc-binding domain PHD_2 PF13831.4 001079887.1_45724001_2 - 0.027 13.9 1.1 0.047 13.1 1.1 1.4 1 0 0 1 1 1 0 PHD-finger FlxA PF14282.4 001079887.1_45724001_2 - 0.14 12.0 3.3 0.18 11.7 2.3 1.7 1 1 0 1 1 1 0 FlxA-like protein LMBR1 PF04791.14 001079887.1_45724001_2 - 4 6.1 4.2 6.1 5.5 4.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein HLH PF00010.24 001108267.1_45725001_1 - 5.3e-17 61.4 0.2 2.3e-16 59.4 0.2 2.1 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain COE1_HLH PF16423.3 001108267.1_45725001_1 - 0.0049 16.4 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 Transcription factor COE1 helix-loop-helix domain IL6Ra-bind PF09240.8 001037660.1_45723001_1 - 7.3e-18 64.7 0.0 1.8e-17 63.4 0.0 1.7 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding SH2 PF00017.22 001032837.1_29621001_1 - 1.3e-14 53.9 0.0 1.7e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 SH2 domain MarR_2 PF12802.5 001109441.1_45722001_1 - 0.11 12.3 0.2 0.18 11.6 0.2 1.3 1 0 0 1 1 1 0 MarR family LRR_9 PF14580.4 001109441.1_45722001_3 - 5.5e-14 51.9 1.8 1.4e-13 50.6 1.8 1.5 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.5 001109441.1_45722001_3 - 1.9e-06 28.0 17.5 0.00016 21.8 6.5 3.9 1 1 3 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001109441.1_45722001_3 - 0.0024 17.5 16.9 0.05 13.2 3.9 3.2 3 1 0 3 3 3 2 Leucine rich repeat LRR_6 PF13516.4 001109441.1_45722001_3 - 5.6 7.2 9.6 29 4.9 0.8 3.6 3 0 0 3 3 3 0 Leucine Rich repeat Presenilin PF01080.15 001078666.1_49823001_1 - 2.3e-153 510.6 28.0 4.3e-107 358.2 19.9 2.3 1 1 1 2 2 2 2 Presenilin SET PF00856.26 001107475.1_45725001_1 - 7e-11 42.7 0.0 1e-10 42.1 0.0 1.3 1 0 0 1 1 1 1 SET domain TSNAXIP1_N PF15739.3 001109130.1_45726001_1 - 2.1e-29 102.0 5.4 2.1e-29 102.0 5.4 3.3 3 1 0 3 3 3 1 Translin-associated factor X-interacting N-terminus SUI1 PF01253.20 001106867.1_45722001_2 - 2.7e-28 98.2 1.0 4.8e-28 97.4 1.0 1.4 1 0 0 1 1 1 1 Translation initiation factor SUI1 EpoR_lig-bind PF09067.8 001082231.1_37926001_3 - 2.4e-21 75.7 0.0 2.4e-21 75.7 0.0 2.1 2 0 0 2 2 2 1 Erythropoietin receptor, ligand binding IL6Ra-bind PF09240.8 001082231.1_37926001_3 - 1.2e-07 31.9 0.1 3.1e-07 30.6 0.1 1.7 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding fn3 PF00041.19 001082231.1_37926001_3 - 4.7e-07 29.9 1.0 0.00066 19.8 0.1 2.7 2 1 0 2 2 2 2 Fibronectin type III domain Sigma54_AID PF00309.18 001108236.1_45729001_1 - 0.54 10.0 1.6 0.96 9.2 1.6 1.3 1 0 0 1 1 1 0 Sigma-54 factor, Activator interacting domain (AID) LNS2 PF08235.11 001108236.1_45729001_2 - 9.4e-103 342.4 0.0 1.4e-102 341.9 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.12 001108236.1_45729001_2 - 1.3e-44 150.2 0.0 2.2e-44 149.5 0.0 1.4 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.3 001108236.1_45729001_2 - 6.2e-35 119.3 0.1 1.9e-34 117.8 0.1 1.8 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain WRNPLPNID PF15017.4 001108236.1_45729001_2 - 3e-05 24.7 0.4 9.6e-05 23.1 0.4 1.9 1 0 0 1 1 1 1 Putative WW-binding domain and destruction box Integrin_alpha2 PF08441.10 001108156.1_45729001_2 - 2.2e-43 148.7 0.0 3.1e-43 148.2 0.0 1.2 1 0 0 1 1 1 1 Integrin alpha VWA PF00092.26 001108156.1_45729001_2 - 6.7e-40 137.1 0.1 1.2e-39 136.2 0.1 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain FG-GAP PF01839.21 001108156.1_45729001_2 - 2.4e-14 53.0 9.7 3.4e-05 23.7 0.0 4.7 5 0 0 5 5 5 3 FG-GAP repeat VWA_2 PF13519.4 001108156.1_45729001_2 - 5.8e-14 52.5 0.0 1.7e-13 51.0 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain VCBS PF13517.4 001108156.1_45729001_2 - 1.2e-06 28.8 0.4 0.0038 17.6 0.0 3.2 1 1 2 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.4 001108156.1_45729001_2 - 1.7e-06 28.0 8.3 0.22 11.7 0.1 4.3 4 0 0 4 4 4 3 FG-GAP repeat Ku_N PF03731.13 001108156.1_45729001_2 - 0.0042 16.7 0.0 0.0077 15.9 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain MOEP19 PF16005.3 001106837.1_45724001_1 - 6.6e-33 112.5 0.2 1e-32 111.8 0.2 1.3 1 0 0 1 1 1 1 KH-like RNA-binding domain DUF824 PF05688.9 001106837.1_45724001_1 - 5.7e-05 22.7 37.0 12 5.7 0.3 12.7 1 1 13 14 14 14 7 Salmonella repeat of unknown function (DUF824) DUF1652 PF07865.9 001106837.1_45724001_1 - 0.49 10.1 5.0 12 5.6 0.2 3.9 1 1 2 4 4 4 0 Protein of unknown function (DUF1652) Drf_FH1 PF06346.10 001106837.1_45724001_2 - 4.4 6.8 52.9 6.4 6.3 41.4 2.6 2 1 1 3 3 3 0 Formin Homology Region 1 SSF PF00474.15 001082193.2_37925001_3 - 4.2e-142 473.6 18.4 5.6e-142 473.2 18.4 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family DUF1426 PF07234.9 001082193.2_37925001_3 - 0.056 13.5 1.8 1.1 9.4 0.0 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF1426) T2SSM PF04612.10 001082193.2_37925001_3 - 0.32 10.9 2.0 1.6 8.7 0.3 2.4 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M IBV_3C PF03620.11 001082193.2_37925001_3 - 0.53 10.7 3.9 0.39 11.1 0.5 2.5 2 0 0 2 2 2 0 IBV 3C protein DUF2569 PF10754.7 001082193.2_37925001_3 - 3.4 8.0 21.4 0.25 11.6 2.3 4.0 3 1 0 3 3 3 0 Protein of unknown function (DUF2569) ubiquitin PF00240.21 001108251.1_45727001_1 - 6.3e-18 64.1 1.9 1.1e-17 63.4 1.9 1.4 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.29 001108251.1_45727001_1 - 2.5e-07 30.3 1.0 6e-07 29.1 1.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.6 001108251.1_45727001_1 - 9e-07 28.5 1.0 1.8e-06 27.6 1.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.8 001108251.1_45727001_1 - 0.0011 19.5 0.0 0.0024 18.4 0.0 1.6 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD Rad60-SLD_2 PF13881.4 001108251.1_45727001_1 - 0.0029 17.5 0.4 0.0061 16.5 0.4 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 001108251.1_45727001_1 - 0.011 16.2 0.1 0.026 15.0 0.1 1.6 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Atg8 PF02991.14 001108251.1_45727001_1 - 0.024 14.7 0.1 0.047 13.8 0.1 1.4 1 0 0 1 1 1 0 Autophagy protein Atg8 ubiquitin like HOIP-UBA PF16678.3 001108251.1_45727001_1 - 0.14 12.0 0.1 0.36 10.7 0.1 1.6 1 0 0 1 1 1 0 UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase WD40 PF00400.30 001081634.1_45724001_2 - 1.3e-11 44.7 17.5 0.041 14.6 2.7 5.9 6 0 0 6 6 6 5 WD domain, G-beta repeat WD40_like PF17005.3 001081634.1_45724001_2 - 2.6e-07 30.1 0.0 3.6e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 WD40-like domain F-box-like PF12937.5 001081634.1_45724001_2 - 0.00036 20.2 4.2 0.00086 19.0 4.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001081634.1_45724001_2 - 0.0064 16.2 1.0 0.0064 16.2 1.0 2.1 2 0 0 2 2 2 1 F-box domain PQQ_3 PF13570.4 001081634.1_45724001_2 - 0.083 13.3 4.5 4 7.9 0.0 4.2 6 0 0 6 6 6 0 PQQ-like domain TM2 PF05154.14 001108670.1_45723001_2 - 2.6e-16 59.5 5.2 5.1e-16 58.6 5.2 1.5 1 0 0 1 1 1 1 TM2 domain Sybindin PF04099.10 001039378.1_45722001_1 - 1.6e-45 154.4 0.0 1.9e-45 154.2 0.0 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.11 001039378.1_45722001_1 - 0.011 15.7 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 0 Sedlin, N-terminal conserved region Kunitz_BPTI PF00014.21 001082549.1_45723001_1 - 5.6e-35 119.2 18.0 5.7e-18 64.8 4.0 2.5 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Synuclein PF01387.15 001037145.1_49822001_2 - 9e-52 174.7 17.5 1.1e-51 174.4 17.5 1.1 1 0 0 1 1 1 1 Synuclein Lectin_C PF00059.19 001085404.1_45722001_1 - 1.4e-10 41.7 1.3 1.4e-10 41.7 1.3 2.1 2 1 0 2 2 2 1 Lectin C-type domain UL45 PF05473.10 001085404.1_45722001_1 - 2e-05 24.2 0.2 2.6e-05 23.8 0.2 1.2 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like dsDNA_bind PF01984.18 001106247.1_45722001_2 - 4.2e-33 113.8 9.5 5.5e-33 113.4 9.5 1.1 1 0 0 1 1 1 1 Double-stranded DNA-binding domain EF-1_beta_acid PF10587.7 001106247.1_45722001_2 - 0.053 13.8 3.5 0.053 13.8 3.5 2.6 3 0 0 3 3 3 0 Eukaryotic elongation factor 1 beta central acidic region fn3 PF00041.19 001107278.2_45728001_1 - 6.3e-77 253.9 0.0 5.5e-11 42.5 0.0 10.4 10 0 0 10 10 10 9 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 001107278.2_45728001_1 - 3.4e-16 59.5 3.5 0.13 12.7 0.0 7.4 8 1 0 8 8 8 5 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.7 001107278.2_45728001_1 - 3.5e-09 36.9 0.0 0.13 12.6 0.0 6.6 7 1 0 7 7 7 2 Uncharacterised conserved protein (DUF2369) fn3_4 PF16794.3 001107278.2_45728001_1 - 0.015 15.0 0.0 1.3e+02 2.4 0.0 5.4 6 0 0 6 6 6 0 Fibronectin-III type domain IL6Ra-bind PF09240.8 001107278.2_45728001_1 - 0.067 13.5 1.6 2.1 8.7 0.2 2.7 2 0 0 2 2 2 0 Interleukin-6 receptor alpha chain, binding Na_K-ATPase PF00287.16 001082780.1_37922001_1 - 5e-112 373.6 2.0 5.7e-112 373.4 2.0 1.0 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain Trypsin PF00089.24 001107619.1_45726001_2 - 1.2e-70 237.6 0.1 1.7e-70 237.2 0.1 1.2 1 0 0 1 1 1 1 Trypsin SRCR_2 PF15494.4 001107619.1_45726001_2 - 5.6e-24 84.4 0.3 1.1e-23 83.5 0.3 1.5 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR PF00530.16 001107619.1_45726001_2 - 3e-06 27.5 0.1 6.9e-06 26.4 0.1 1.6 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Ldl_recept_a PF00057.16 001107619.1_45726001_2 - 4.1e-06 26.8 8.7 9.8e-06 25.6 8.7 1.6 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A DUF1986 PF09342.9 001107619.1_45726001_2 - 9.4e-05 22.6 0.1 0.00022 21.4 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 001107619.1_45726001_2 - 0.0043 17.8 0.0 0.01 16.6 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain CHGN PF05679.14 001106268.1_45728001_3 - 1.6e-201 670.5 0.2 1.9e-201 670.3 0.2 1.1 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Fringe PF02434.14 001106268.1_45728001_3 - 1.9e-18 66.7 0.0 3.5e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 Fringe-like Glyco_transf_7C PF02709.12 001106268.1_45728001_3 - 6.3e-10 38.4 0.2 1.4e-09 37.3 0.2 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.7 001106268.1_45728001_3 - 3.2e-06 26.7 0.1 0.00012 21.6 0.1 2.7 2 1 0 2 2 2 1 Glycosyltransferase like family 2 Galactosyl_T PF01762.19 001106268.1_45728001_3 - 0.0019 17.9 0.0 0.012 15.4 0.0 2.3 2 1 0 2 2 2 1 Galactosyltransferase Glyco_transf_21 PF13506.4 001106268.1_45728001_3 - 0.14 11.5 0.0 0.7 9.2 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase family 21 Sulfotransfer_1 PF00685.25 001107427.1_45725001_3 - 1.4e-20 73.8 0.0 1.9e-20 73.3 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 001107427.1_45725001_3 - 9.1e-14 52.2 0.4 1.5e-12 48.2 0.4 2.3 1 1 0 1 1 1 1 Sulfotransferase family DUF3689 PF12463.6 001100748.1_45727001_1 - 1.8e-131 437.8 14.7 2.8e-131 437.2 14.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3689) Put_DNA-bind_N PF06971.11 001100748.1_45727001_1 - 0.44 10.5 1.5 1.2 9.1 1.5 1.7 1 0 0 1 1 1 0 Putative DNA-binding protein N-terminus Peptidase_M10 PF00413.22 001082771.1_37924001_1 - 7.5e-61 204.5 0.1 1.1e-60 204.0 0.1 1.2 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 001082771.1_37924001_1 - 1.5e-43 146.3 15.1 9.7e-15 54.1 0.2 4.4 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.16 001082771.1_37924001_1 - 3.6e-15 55.8 1.6 8.2e-15 54.6 0.1 2.1 2 0 0 2 2 2 1 Putative peptidoglycan binding domain Astacin PF01400.22 001082771.1_37924001_1 - 4.8e-05 22.9 0.0 0.38 10.2 0.0 2.4 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.4 001082771.1_37924001_1 - 0.0033 17.8 0.0 0.0059 17.0 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Metallopep PF12044.6 001082771.1_37924001_1 - 0.022 13.3 0.1 0.034 12.6 0.1 1.2 1 0 0 1 1 1 0 Putative peptidase family Peptidase_M66 PF10462.7 001082771.1_37924001_1 - 0.074 11.8 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Peptidase M66 DUF4953 PF16313.3 001082771.1_37924001_1 - 0.096 11.7 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Met-zincin Mito_carr PF00153.25 001030032.1_45724001_1 - 3.8e-57 190.1 6.4 3.6e-21 74.8 0.0 3.2 2 1 1 3 3 3 3 Mitochondrial carrier protein NDUF_C2 PF06374.9 001071781.1_39721001_1 - 2e-47 159.8 0.0 2.3e-47 159.6 0.0 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) Defensin_beta_2 PF13841.4 001037512.1_45721001_1 - 2.4e-07 31.0 11.7 3e-07 30.7 11.7 1.1 1 0 0 1 1 1 1 Beta defensin Fcf2 PF08698.9 001037512.1_45721001_1 - 0.036 14.3 0.0 0.037 14.3 0.0 1.1 1 0 0 1 1 1 0 Fcf2 pre-rRNA processing Headcase PF16002.3 001107514.1_45729001_3 - 2.6e-82 274.9 4.0 5.8e-82 273.8 4.0 1.5 1 0 0 1 1 1 1 Headcase protein HECA PF15353.4 001107514.1_45729001_3 - 4.4e-39 132.7 9.8 1.1e-38 131.5 9.8 1.7 1 0 0 1 1 1 1 Headcase protein family homologue MHC_I_3 PF16497.3 001025733.2_45723001_2 - 8.5e-21 74.2 0.2 1.2e-20 73.8 0.2 1.1 1 0 0 1 1 1 1 MHC-I family domain MHC_I PF00129.16 001025733.2_45723001_2 - 7.8e-05 22.2 0.0 0.00013 21.5 0.0 1.3 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Ets PF00178.20 001108080.1_45723001_2 - 2.3e-22 79.1 1.5 3.9e-22 78.4 1.5 1.4 1 0 0 1 1 1 1 Ets-domain zf-met PF12874.5 001107338.1_45727001_1 - 6.6e-22 77.1 26.9 3.7e-07 30.2 1.6 4.7 4 0 0 4 4 4 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 001107338.1_45727001_1 - 2.2e-12 46.8 22.9 0.0068 16.6 0.4 4.7 4 0 0 4 4 4 4 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 001107338.1_45727001_1 - 0.0024 18.0 21.9 0.0043 17.2 2.8 4.2 2 1 2 4 4 4 2 C2H2 type zinc-finger (2 copies) zf-U1 PF06220.10 001107338.1_45727001_1 - 0.0063 16.1 16.0 0.4 10.4 1.4 4.5 4 0 0 4 4 4 4 U1 zinc finger zf-C2H2 PF00096.24 001107338.1_45727001_1 - 1.7 9.1 14.0 11 6.5 1.7 4.5 3 0 0 3 3 3 0 Zinc finger, C2H2 type Vps16_C PF04840.10 001101004.1_45725001_1 - 5.2e-08 32.2 2.5 0.00079 18.4 0.1 2.2 2 0 0 2 2 2 2 Vps16, C-terminal region BTB PF00651.29 001108279.1_45727001_1 - 1.3e-24 86.4 0.0 1.9e-24 85.9 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 001108279.1_45727001_1 - 1.2e-22 79.1 50.5 1.5e-06 28.3 0.6 6.7 7 0 0 7 7 5 5 Zinc-finger double domain zf-C2H2 PF00096.24 001108279.1_45727001_1 - 1.8e-15 56.3 37.3 0.00024 21.3 0.4 6.2 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001108279.1_45727001_1 - 3.5e-08 33.5 38.9 0.01 16.4 0.3 6.8 6 0 0 6 6 6 4 C2H2-type zinc finger zf-met PF12874.5 001108279.1_45727001_1 - 1.8e-06 28.0 25.0 0.00079 19.6 0.2 6.2 6 0 0 6 6 6 3 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.8 001108279.1_45727001_1 - 0.0051 16.8 1.3 0.0051 16.8 1.3 4.6 1 1 5 6 6 6 3 Zinc ribbon domain zf-C2H2_6 PF13912.4 001108279.1_45727001_1 - 0.011 15.5 0.1 0.011 15.5 0.1 6.2 6 0 0 6 6 5 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001108279.1_45727001_1 - 0.062 13.5 7.4 17 5.7 0.3 4.9 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_9 PF14369.4 001108279.1_45727001_1 - 0.3 11.3 5.1 40 4.4 0.1 4.4 3 0 0 3 3 3 0 zinc-ribbon zf-Sec23_Sec24 PF04810.13 001108279.1_45727001_1 - 0.59 10.1 8.0 5.9 6.9 0.3 3.9 3 1 1 4 4 4 0 Sec23/Sec24 zinc finger ADK_lid PF05191.12 001108279.1_45727001_1 - 3 7.8 9.0 1.7 8.6 0.7 3.0 2 0 0 2 2 2 0 Adenylate kinase, active site lid zf-C2H2_9 PF16293.3 001108279.1_45727001_1 - 4.7 7.0 5.6 5.3 6.8 0.3 3.3 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) DUF4668 PF15701.3 001108279.1_45727001_1 - 4.8 6.8 6.3 2.7 7.7 0.9 2.7 3 0 0 3 3 2 0 Domain of unknown function (DUF4668) Forkhead PF00250.16 001105935.1_45726001_3 - 8.3e-31 106.0 0.0 1.4e-30 105.3 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain Ferric_reduct PF01794.17 001106629.1_45723001_3 - 9.8e-15 54.7 2.3 9.8e-15 54.7 2.3 2.3 1 1 1 2 2 2 2 Ferric reductase like transmembrane component PGM_PMM_II PF02879.14 001106007.1_45725001_3 - 4e-24 85.1 0.1 9.6e-24 83.8 0.1 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.14 001106007.1_45725001_3 - 7.7e-12 45.3 0.0 1.7e-11 44.2 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.18 001106007.1_45725001_3 - 4.8e-06 26.5 0.0 9.5e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_I PF02878.14 001106007.1_45725001_3 - 0.006 16.2 0.1 0.14 11.8 0.0 2.3 1 1 1 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I Rotavirus_VP3 PF06929.9 001106007.1_45725001_3 - 0.08 11.0 0.2 0.35 8.9 0.1 1.8 2 0 0 2 2 2 0 Rotavirus VP3 protein C1q PF00386.19 001107221.1_45723001_1 - 6e-38 129.8 0.0 8.3e-38 129.3 0.0 1.2 1 0 0 1 1 1 1 C1q domain Collagen PF01391.16 001107221.1_45723001_1 - 8.2e-17 60.6 54.5 4.6e-09 35.8 24.8 2.3 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) COX6B PF02297.15 144613.4_26224001_1 - 1.4e-16 60.4 2.1 2.2e-16 59.7 2.1 1.3 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CX9C PF16860.3 144613.4_26224001_1 - 0.14 12.0 0.5 0.47 10.4 0.5 1.9 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, QIL1 PF15884.3 001097463.2_49822001_1 - 2.4e-26 92.0 0.0 3.1e-26 91.7 0.0 1.2 1 0 0 1 1 1 1 Protein QIL1 BEX PF04538.10 001109401.1_45722001_2 - 1.3e-20 74.1 10.9 3.5e-20 72.8 10.9 1.5 1 1 0 1 1 1 1 Brain expressed X-linked like family Rho_GDI PF02115.15 001108269.1_45723001_1 - 2.4e-58 196.9 0.0 3e-58 196.6 0.0 1.1 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor 7tm_1 PF00001.19 001037359.1_45722001_1 - 5.6e-35 120.7 19.4 8.5e-35 120.2 19.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001037359.1_45722001_1 - 2.1e-05 23.9 13.8 2.9e-05 23.4 13.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx PRRSV_2b PF07069.9 001037359.1_45722001_1 - 1.1 9.6 0.1 1.1 9.6 0.1 3.1 4 0 0 4 4 4 0 Porcine reproductive and respiratory syndrome virus 2b SieB PF14163.4 001037359.1_45722001_1 - 3.4 7.0 6.1 0.64 9.4 0.2 2.6 3 0 0 3 3 3 0 Super-infection exclusion protein B CHZ PF09649.8 001025725.1_45725001_3 - 4.4e-10 38.7 0.5 1.1e-09 37.4 0.5 1.7 1 0 0 1 1 1 1 Histone chaperone domain CHZ Trypsin PF00089.24 001034120.1_39725001_1 - 4.2e-49 167.2 0.0 6.6e-49 166.6 0.0 1.3 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 001034120.1_39725001_1 - 4.6e-49 165.2 0.0 2.4e-28 98.5 0.0 2.4 2 0 0 2 2 2 2 CUB domain Sushi PF00084.18 001034120.1_39725001_1 - 2.1e-20 73.0 17.4 7.1e-13 48.8 0.5 3.7 3 0 0 3 3 3 2 Sushi repeat (SCR repeat) FXa_inhibition PF14670.4 001034120.1_39725001_1 - 2.2e-10 40.5 8.9 3.8e-10 39.8 6.5 2.6 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site cEGF PF12662.5 001034120.1_39725001_1 - 7.8e-07 28.8 6.3 0.00011 21.9 3.7 3.0 2 0 0 2 2 2 2 Complement Clr-like EGF-like EGF_CA PF07645.13 001034120.1_39725001_1 - 4.8e-06 26.5 6.3 4.8e-06 26.5 6.3 3.4 3 1 0 3 3 3 1 Calcium-binding EGF domain EGF PF00008.25 001034120.1_39725001_1 - 0.0044 17.2 6.4 0.0044 17.2 6.4 2.6 2 0 0 2 2 2 1 EGF-like domain hEGF PF12661.5 001034120.1_39725001_1 - 0.0048 17.4 7.1 0.0054 17.2 4.1 2.8 2 0 0 2 2 2 1 Human growth factor-like EGF Trypsin_2 PF13365.4 001034120.1_39725001_1 - 0.0064 17.3 0.0 0.025 15.3 0.0 2.0 1 1 0 1 1 1 1 Trypsin-like peptidase domain CUB_2 PF02408.18 001034120.1_39725001_1 - 0.019 14.6 0.0 1.9 8.1 0.0 2.5 2 0 0 2 2 2 0 CUB-like domain RhoGAP PF00620.25 001108112.1_45725001_2 - 1.4e-42 145.0 0.1 2.4e-42 144.2 0.1 1.4 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.20 001108112.1_45725001_2 - 2.1e-07 30.6 2.2 4.6e-07 29.5 2.2 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) FEZ PF07763.11 053600.2_45723001_1 - 1.1e-91 306.7 11.6 1.4e-91 306.4 11.6 1.1 1 0 0 1 1 1 1 FEZ-like protein DUF5102 PF17104.3 053600.2_45723001_1 - 1.1e-05 25.5 7.6 0.00013 22.0 6.6 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF5102) MRP-L46 PF11788.6 053600.2_45723001_1 - 0.15 12.7 6.7 0.11 13.2 4.1 1.9 1 1 1 2 2 2 0 39S mitochondrial ribosomal protein L46 NPV_P10 PF05531.10 053600.2_45723001_1 - 0.49 10.7 4.5 58 4.1 0.0 3.5 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein CorA PF01544.16 053600.2_45723001_1 - 1.4 8.0 6.9 2.6 7.2 6.9 1.5 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein V_ATPase_I PF01496.17 053600.2_45723001_1 - 3.1 5.4 8.7 4 5.1 8.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DivIVA PF05103.11 053600.2_45723001_1 - 3.9 7.4 17.0 4.4 7.3 10.0 2.2 1 1 1 2 2 2 0 DivIVA protein Acyltransferase PF01553.19 001012727.1_26223001_1 - 3.1e-15 55.9 0.1 1.4e-14 53.7 0.0 2.0 1 1 1 2 2 2 1 Acyltransferase PIP5K PF01504.16 001033970.1_45729001_2 - 4.5e-93 311.3 0.0 6.3e-93 310.8 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Homeobox PF00046.27 001071827.1_39723001_1 - 1.3e-18 66.4 5.8 2.4e-18 65.6 5.8 1.4 1 0 0 1 1 1 1 Homeobox domain Nodulin_late PF07127.9 001071827.1_39723001_1 - 0.03 14.5 0.6 0.064 13.5 0.6 1.4 1 0 0 1 1 1 0 Late nodulin protein Homez PF11569.6 001071827.1_39723001_1 - 0.73 9.2 5.1 0.091 12.1 0.6 1.8 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez IL8 PF00048.18 001108661.1_45722001_3 - 7.2e-18 64.4 0.0 1.1e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like RRM_1 PF00076.20 001033901.1_45726001_1 - 1.7e-06 27.6 0.0 3.4e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-met PF12874.5 001033901.1_45726001_1 - 6e-06 26.3 0.3 1.4e-05 25.2 0.3 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type PAP_assoc PF03828.17 001033901.1_45726001_1 - 2.1e-05 24.5 0.0 5.3e-05 23.2 0.0 1.8 1 0 0 1 1 1 1 Cid1 family poly A polymerase zf-C2H2_jaz PF12171.6 001033901.1_45726001_1 - 0.00069 19.7 0.0 0.0015 18.7 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding RRM_7 PF16367.3 001033901.1_45726001_1 - 0.039 13.9 0.0 0.095 12.7 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif zf-C2H2_2 PF12756.5 001033901.1_45726001_1 - 0.086 13.1 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Arfaptin PF06456.11 030844.2_45724001_3 - 1.4e-91 306.0 10.3 2.1e-91 305.5 10.3 1.2 1 0 0 1 1 1 1 Arfaptin-like domain ICA69 PF04629.12 030844.2_45724001_3 - 1.8e-61 208.6 14.8 7e-43 147.6 5.8 2.5 1 1 1 2 2 2 2 Islet cell autoantigen ICA69, C-terminal domain CHCH PF06747.11 001071800.1_39722001_1 - 5.2e-10 39.1 2.8 5.2e-10 39.1 2.8 2.4 2 1 0 2 2 2 1 CHCH domain CX9C PF16860.3 001071800.1_39722001_1 - 0.00074 19.3 10.7 0.0011 18.8 2.5 2.6 2 1 0 2 2 2 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.8 001071800.1_39722001_1 - 0.015 15.2 1.2 0.015 15.2 1.2 2.5 1 1 2 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like Cdd1 PF11731.6 001071800.1_39722001_1 - 0.029 14.5 2.2 4 7.6 0.2 2.3 1 1 1 2 2 2 0 Pathogenicity locus UCR_hinge PF02320.14 001071800.1_39722001_1 - 6.1 7.0 11.9 9.4 6.4 4.7 3.0 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein DUF3716 PF12511.6 001071800.1_39722001_1 - 7.1 6.6 7.6 4.1 7.4 0.6 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF3716) COX6B PF02297.15 001071800.1_39722001_1 - 8.7 6.5 12.3 0.33 11.1 4.0 2.1 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb Pet191_N PF10203.7 001071800.1_39722001_1 - 9.2 6.5 10.6 22 5.3 0.4 3.0 1 1 2 3 3 3 0 Cytochrome c oxidase assembly protein PET191 Spc97_Spc98 PF04130.11 001107323.1_45728001_2 - 6.8e-38 130.6 0.0 1.1e-37 130.0 0.0 1.4 2 0 0 2 2 2 1 Spc97 / Spc98 family Spc97_Spc98 PF04130.11 001107323.1_45728001_3 - 9.6e-73 245.6 0.7 1.4e-72 245.1 0.7 1.2 1 0 0 1 1 1 1 Spc97 / Spc98 family ERCC4 PF02732.13 001025645.1_45724001_1 - 4.8e-25 88.4 0.0 8.2e-25 87.7 0.0 1.4 1 0 0 1 1 1 1 ERCC4 domain MutL PF13941.4 001025645.1_45724001_1 - 0.014 13.9 0.0 0.023 13.2 0.0 1.2 1 0 0 1 1 1 0 MutL protein CSRNP_N PF16019.3 001108113.1_45729001_3 - 7.6e-102 339.7 6.5 7.6e-102 339.7 6.5 2.0 2 0 0 2 2 2 1 Cysteine/serine-rich nuclear protein N-terminus Homeobox PF00046.27 001081484.1_39726001_1 - 3.9e-35 119.3 14.9 1.8e-07 30.8 0.0 5.4 5 0 0 5 5 5 5 Homeobox domain Homez PF11569.6 001081484.1_39726001_1 - 5.3e-21 73.7 6.7 8.8e-12 44.2 0.3 5.4 5 0 0 5 5 5 5 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.9 001081484.1_39726001_1 - 1.7e-18 66.1 9.1 0.00049 19.8 0.1 5.8 5 0 0 5 5 5 5 Homeobox KN domain Cpn60_TCP1 PF00118.22 001081484.1_39726001_1 - 0.024 13.1 0.9 0.039 12.5 0.9 1.2 1 0 0 1 1 1 0 TCP-1/cpn60 chaperonin family Lectin_N PF03954.12 001081484.1_39726001_1 - 2 8.1 3.9 5.9 6.5 2.1 2.5 3 0 0 3 3 3 0 Hepatic lectin, N-terminal domain zf-C2H2 PF00096.24 001081484.1_39726001_1 - 7.9 7.0 7.1 17 6.0 0.6 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type EGF_2 PF07974.11 001108795.1_45727001_1 - 0.69 10.2 11.2 0.88 9.9 4.3 2.9 2 0 0 2 2 2 0 EGF-like domain Kazal_2 PF07648.13 001108795.1_45727001_2 - 5.3e-15 55.2 21.4 4.4e-08 33.1 3.4 3.4 3 0 0 3 3 3 2 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 001108795.1_45727001_2 - 5.2e-11 42.2 29.0 5.8e-07 29.3 6.6 3.3 2 1 1 3 3 3 2 Kazal-type serine protease inhibitor domain PTS_2-RNA PF01885.14 001106331.1_45726001_2 - 8.6e-62 208.3 0.0 1.2e-61 207.8 0.0 1.2 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family DND1_DSRM PF14709.5 001109379.1_45724001_3 - 1.2e-26 92.6 0.0 2.1e-26 91.8 0.0 1.4 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 RRM_1 PF00076.20 001109379.1_45724001_3 - 3.2e-15 55.6 0.0 6.9e-11 41.7 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001109379.1_45724001_3 - 0.18 11.8 0.0 0.66 10.0 0.0 1.9 2 0 0 2 2 2 0 RNA recognition motif Lectin_C PF00059.19 173292.2_45722001_1 - 1.1e-20 74.2 1.7 1.1e-20 74.2 1.7 1.6 1 1 1 2 2 2 1 Lectin C-type domain UL45 PF05473.10 173292.2_45722001_1 - 4.6e-07 29.5 2.4 1.6e-06 27.8 2.4 1.8 1 1 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like DUF1079 PF06435.9 001044286.1_45722001_1 - 0.13 12.4 0.5 0.24 11.5 0.5 1.4 1 0 0 1 1 1 0 Repeat of unknown function (DUF1079) MEA1 PF06910.9 001044286.1_45722001_3 - 7.8e-109 360.8 10.0 9.3e-109 360.6 10.0 1.1 1 0 0 1 1 1 1 Male enhanced antigen 1 (MEA1) Porin_3 PF01459.20 001082075.1_37922001_1 - 1.7e-83 280.1 3.8 1.9e-83 279.9 3.8 1.0 1 0 0 1 1 1 1 Eukaryotic porin Peptidase_M10 PF00413.22 001082037.1_37927001_1 - 1.5e-66 223.0 0.1 2.2e-66 222.4 0.1 1.3 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 001082037.1_37927001_1 - 2e-40 136.3 4.7 5e-12 45.4 0.0 4.4 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.16 001082037.1_37927001_1 - 4e-11 42.8 0.0 6.9e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Reprolysin_3 PF13582.4 001082037.1_37927001_1 - 0.0039 17.6 0.0 0.0067 16.8 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 001082037.1_37927001_1 - 0.016 14.7 0.0 0.026 14.0 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.22 001082037.1_37927001_1 - 0.049 13.1 0.1 7.2 6.0 0.0 2.2 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Complex1_LYR PF05347.13 001071791.1_39721001_1 - 2.4e-09 36.9 0.0 4.1e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.4 001071791.1_39721001_1 - 0.00024 21.6 0.0 0.00034 21.2 0.0 1.3 1 0 0 1 1 1 1 Complex1_LYR-like DUF4252 PF14060.4 001071791.1_39721001_1 - 0.07 12.9 0.2 0.1 12.4 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4252) CcmD PF04995.12 001071791.1_39721001_2 - 0.18 11.7 0.1 0.36 10.8 0.1 1.4 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) CALM_bind PF16025.3 001108501.1_45729001_3 - 1.2e-19 70.4 10.5 4.2e-18 65.4 1.0 3.3 3 0 0 3 3 3 2 Calcium-dependent calmodulin binding Porphobil_deam PF01379.18 013168.2_45724001_2 - 8.3e-78 260.5 0.0 1.1e-77 260.1 0.0 1.2 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.13 013168.2_45724001_2 - 8.7e-23 80.4 0.0 5.3e-22 77.8 0.0 2.2 1 1 1 2 2 2 1 Porphobilinogen deaminase, C-terminal domain YAF2_RYBP PF17219.1 001107879.1_45729001_3 - 1.4e-19 69.1 1.2 2.4e-19 68.4 1.2 1.4 1 0 0 1 1 1 1 Yaf2/RYBP C-terminal binding motif zf-RanBP PF00641.16 001107879.1_45729001_3 - 3e-07 29.5 2.4 3e-07 29.5 2.4 2.6 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others Geminin PF07412.10 001106112.1_45723001_1 - 1.8e-76 256.2 10.1 2.2e-76 255.9 10.1 1.1 1 0 0 1 1 1 1 Geminin YscO PF07321.10 001106112.1_45723001_1 - 0.0027 17.5 4.4 0.0047 16.8 4.4 1.3 1 0 0 1 1 1 1 Type III secretion protein YscO Fmp27_WPPW PF10359.7 001106112.1_45723001_1 - 0.0062 15.3 5.6 0.0084 14.9 5.6 1.1 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF641 PF04859.10 001106112.1_45723001_1 - 0.02 15.1 2.2 0.032 14.4 2.2 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Phage_GP20 PF06810.9 001106112.1_45723001_1 - 0.023 14.4 2.2 0.038 13.7 2.2 1.3 1 0 0 1 1 1 0 Phage minor structural protein GP20 CCDC-167 PF15188.4 001106112.1_45723001_1 - 0.031 14.5 2.7 0.065 13.4 2.7 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 DivIC PF04977.13 001106112.1_45723001_1 - 0.042 13.5 3.1 0.087 12.5 3.1 1.5 1 0 0 1 1 1 0 Septum formation initiator APC_N_CC PF16689.3 001106112.1_45723001_1 - 0.05 13.5 1.3 0.11 12.5 1.3 1.5 1 0 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain PRKG1_interact PF15898.3 001106112.1_45723001_1 - 0.13 13.0 5.1 0.27 12.0 5.1 1.5 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain IncA PF04156.12 001106112.1_45723001_1 - 0.2 11.3 3.7 0.27 10.9 3.7 1.2 1 0 0 1 1 1 0 IncA protein CCDC92 PF14916.4 001106112.1_45723001_1 - 0.33 10.6 3.3 1.2 8.8 0.1 2.4 2 0 0 2 2 2 0 Coiled-coil domain of unknown function MCC-bdg_PDZ PF10506.7 001033687.1_45725001_2 - 1.5e-28 98.4 33.9 2.2e-26 91.5 3.4 5.0 6 0 0 6 6 5 2 PDZ domain of MCC-2 bdg protein for Usher syndrome Fez1 PF06818.13 001033687.1_45725001_2 - 0.0094 16.3 12.9 0.19 12.0 3.4 2.9 2 1 0 2 2 2 2 Fez1 End3 PF12761.5 001033687.1_45725001_2 - 0.16 12.0 10.1 1.2 9.2 0.6 2.4 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 FPP PF05911.9 001033687.1_45725001_2 - 0.34 9.0 14.5 1.1 7.4 1.2 2.9 3 0 0 3 3 3 0 Filament-like plant protein, long coiled-coil FAM76 PF16046.3 001033687.1_45725001_2 - 0.53 9.5 5.3 0.061 12.5 0.7 1.6 2 0 0 2 2 2 0 FAM76 protein FlaC_arch PF05377.9 001033687.1_45725001_2 - 0.6 10.4 10.3 0.12 12.7 0.8 3.4 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) HALZ PF02183.16 001033687.1_45725001_2 - 1.2 9.3 6.0 1.4 9.1 1.1 3.0 2 0 0 2 2 2 0 Homeobox associated leucine zipper RasGAP_C PF03836.13 001033687.1_45725001_2 - 1.3 9.1 6.2 4.5 7.3 0.0 2.5 2 0 0 2 2 2 0 RasGAP C-terminus PI3K_P85_iSH2 PF16454.3 001033687.1_45725001_2 - 2.1 7.7 15.8 0.61 9.5 0.1 3.5 2 1 1 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain TBPIP PF07106.11 001033687.1_45725001_2 - 2.7 7.6 9.3 3.9 7.1 0.3 2.7 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF1664 PF07889.10 001033687.1_45725001_2 - 3 7.7 8.4 18 5.2 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Spc7 PF08317.9 001033687.1_45725001_2 - 3.8 6.2 14.9 2.4 6.8 0.9 2.5 2 0 0 2 2 2 0 Spc7 kinetochore protein Mei5 PF10376.7 001033687.1_45725001_2 - 4.3 7.0 10.1 7.3 6.3 0.4 3.3 3 0 0 3 3 3 0 Double-strand recombination repair protein Spc24 PF08286.9 001033687.1_45725001_2 - 5.7 7.1 15.1 2 8.5 0.8 3.7 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 YlqD PF11068.6 001033687.1_45725001_2 - 6.2 7.1 17.2 4.9 7.4 10.3 3.0 3 0 0 3 3 3 0 YlqD protein zf-B_box PF00643.22 001108288.1_45727001_2 - 7.7e-09 35.4 8.7 7.7e-09 35.4 8.7 3.4 3 1 0 3 3 3 1 B-box zinc finger MATH PF00917.24 001108288.1_45727001_2 - 1.3e-07 31.6 0.0 3.5e-07 30.2 0.0 1.8 1 0 0 1 1 1 1 MATH domain zf-C3HC4_3 PF13920.4 001108288.1_45727001_2 - 2.7e-05 23.8 15.2 2.7e-05 23.8 15.2 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001108288.1_45727001_2 - 0.0039 16.9 17.1 0.0039 16.9 17.1 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Dynein_heavy PF03028.13 001108288.1_45727001_2 - 0.034 12.3 2.5 0.052 11.7 2.5 1.2 1 0 0 1 1 1 0 Dynein heavy chain and region D6 of dynein motor MRFAP1 PF15155.4 001108288.1_45727001_2 - 0.059 13.8 1.5 0.19 12.1 1.5 1.9 1 0 0 1 1 1 0 MORF4 family-associated protein1 FUSC PF04632.10 001108288.1_45727001_2 - 0.14 10.5 2.6 0.24 9.8 2.6 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF148 PF02520.15 001108288.1_45727001_2 - 0.25 11.3 2.6 0.78 9.7 2.6 1.9 1 0 0 1 1 1 0 Domain of unknown function DUF148 DUF5071 PF16804.3 001108288.1_45727001_2 - 2.4 8.3 4.6 9.3 6.4 3.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF5071) Baculo_PEP_C PF04513.10 001108288.1_45727001_2 - 6.2 6.7 10.1 1.5 8.7 2.5 3.0 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Oxysterol_BP PF01237.16 001107232.1_45728001_1 - 4.7e-143 476.3 0.1 6.4e-143 475.9 0.1 1.2 1 0 0 1 1 1 1 Oxysterol-binding protein PH PF00169.27 001107232.1_45728001_1 - 1e-12 48.3 0.1 2.2e-12 47.3 0.1 1.6 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 001107232.1_45728001_1 - 9.3e-10 38.5 0.1 1.8e-09 37.6 0.1 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.4 001107232.1_45728001_1 - 7.6e-06 26.2 3.9 0.00051 20.3 3.9 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.4 001107232.1_45728001_1 - 0.011 15.9 0.0 0.022 14.9 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain Flu_B_NS1 PF02942.12 001107232.1_45728001_1 - 0.17 10.8 0.1 0.28 10.1 0.1 1.2 1 0 0 1 1 1 0 Influenza B non-structural protein (NS1) betaPIX_CC PF16523.3 001107232.1_45728001_1 - 4.3 7.1 5.4 0.44 10.3 0.3 1.8 2 0 0 2 2 2 0 betaPIX coiled coil Ribosomal_L5e PF17144.2 001035306.2_06523001_3 - 1.1e-93 311.5 0.7 1.1e-93 311.5 0.7 2.0 2 0 0 2 2 2 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.4 001035306.2_06523001_3 - 1.5e-39 134.6 12.4 1.5e-39 134.6 12.4 1.7 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region ANAPC4_WD40 PF12894.5 001099340.1_45729001_3 - 5.5e-12 45.7 8.6 6.3e-06 26.3 0.3 6.0 3 3 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.12 001099340.1_45729001_3 - 3.3e-05 23.0 4.6 0.0022 17.0 0.0 3.1 3 0 0 3 3 3 2 Coatomer WD associated region WD40 PF00400.30 001099340.1_45729001_3 - 0.00013 22.5 3.0 1.5 9.7 0.0 5.4 4 1 1 5 5 5 1 WD domain, G-beta repeat Clathrin PF00637.18 001099340.1_45729001_3 - 0.00038 20.2 1.9 0.00087 19.1 0.6 2.3 1 1 1 2 2 2 1 Region in Clathrin and VPS A2L_zn_ribbon PF08792.8 001099340.1_45729001_3 - 0.023 14.3 2.2 0.084 12.5 2.2 2.0 1 0 0 1 1 1 0 A2L zinc ribbon domain eIF2A PF08662.9 001099340.1_45729001_3 - 0.044 13.5 2.9 0.06 13.1 1.1 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A ArdA PF07275.9 001099340.1_45729001_3 - 0.069 13.6 1.0 0.21 12.0 1.0 1.8 1 0 0 1 1 1 0 Antirestriction protein (ArdA) Cys_rich_CPCC PF14206.4 001099340.1_45729001_3 - 0.25 11.0 3.2 0.98 9.2 2.1 2.5 2 0 0 2 2 2 0 Cysteine-rich CPCC Cmc1 PF08583.8 001099340.1_45729001_3 - 0.75 9.7 5.5 0.2 11.5 0.9 2.4 2 0 0 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Plectin PF00681.18 001107066.1_45729001_1 - 7.9e-44 147.1 0.9 3.1e-12 46.0 0.2 7.3 5 1 2 7 7 7 6 Plectin repeat Spectrin PF00435.19 001107066.1_45729001_1 - 0.011 16.1 1.1 0.011 16.1 1.1 15.8 11 6 3 15 15 15 0 Spectrin repeat Ceramidase PF05875.10 001106875.1_45725001_3 - 1.2e-53 182.2 18.7 1.2e-53 182.2 18.7 1.4 2 0 0 2 2 2 1 Ceramidase Pkinase_Tyr PF07714.15 001105868.1_45729001_2 - 2.5e-93 312.0 0.0 3.4e-93 311.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.17 001105868.1_45729001_2 - 8.2e-72 240.8 0.2 1.2e-71 240.3 0.2 1.3 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.23 001105868.1_45729001_2 - 7.4e-45 153.2 0.0 1e-44 152.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.19 001105868.1_45729001_2 - 8.3e-32 109.3 4.0 1.1e-14 54.4 0.0 3.4 4 0 0 4 4 4 2 Fibronectin type III domain SAM_1 PF00536.28 001105868.1_45729001_2 - 1.5e-21 76.4 0.0 2.6e-21 75.7 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) EphA2_TM PF14575.4 001105868.1_45729001_2 - 2.1e-21 76.4 0.4 4.9e-21 75.2 0.4 1.6 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SAM_2 PF07647.15 001105868.1_45729001_2 - 6.4e-21 74.1 0.0 1.1e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ephrin_rec_like PF07699.11 001105868.1_45729001_2 - 6.7e-06 25.6 9.7 6.7e-06 25.6 9.7 2.7 2 1 1 3 3 3 1 Putative ephrin-receptor like Pur_ac_phosph_N PF16656.3 001105868.1_45729001_2 - 1.9e-05 25.0 0.0 0.0011 19.4 0.1 2.5 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.3 001105868.1_45729001_2 - 0.00055 19.9 0.0 0.31 11.1 0.0 2.7 3 0 0 3 3 3 1 Fibronectin type III domain Interfer-bind PF09294.8 001105868.1_45729001_2 - 0.0057 16.8 0.0 0.3 11.3 0.0 2.7 3 0 0 3 3 3 1 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.7 001105868.1_45729001_2 - 0.018 15.4 0.0 9.5 6.6 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2369) Cadherin_C_2 PF16492.3 001105868.1_45729001_2 - 0.07 13.8 0.1 0.43 11.3 0.0 2.3 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal Ank_2 PF12796.5 001015028.2_45729001_2 - 4e-48 161.8 2.3 6.4e-16 58.6 0.1 5.2 3 1 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_3 PF13606.4 001015028.2_45729001_2 - 5.9e-42 136.7 6.4 1.6e-05 24.8 0.1 10.2 10 0 0 10 10 10 8 Ankyrin repeat Ank PF00023.28 001015028.2_45729001_2 - 1.6e-40 135.7 13.1 2.5e-07 30.7 0.2 7.7 7 0 0 7 7 7 7 Ankyrin repeat Ank_4 PF13637.4 001015028.2_45729001_2 - 7e-39 131.6 5.8 6.8e-09 36.0 0.0 7.6 3 2 5 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.4 001015028.2_45729001_2 - 2.2e-34 116.8 18.1 1.3e-07 31.6 3.0 8.0 4 3 4 8 8 8 7 Ankyrin repeats (many copies) SAM_1 PF00536.28 001015028.2_45729001_2 - 3.7e-09 36.8 0.1 6.6e-09 35.9 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 001015028.2_45729001_2 - 1.7e-06 27.9 0.1 3.1e-06 27.1 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Tmemb_cc2 PF10267.7 001015028.2_45729001_2 - 0.16 11.0 0.4 0.23 10.4 0.4 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Acyltransferase PF01553.19 001047849.1_45727001_1 - 1.1e-18 67.0 0.1 2.1e-18 66.1 0.1 1.5 1 0 0 1 1 1 1 Acyltransferase DBC1 PF14443.4 001108535.1_45729001_3 - 5.2e-51 171.7 0.0 2e-50 169.8 0.0 2.1 1 0 0 1 1 1 1 DBC1 S1-like PF14444.4 001108535.1_45729001_3 - 2.1e-31 107.6 0.9 3.9e-31 106.7 0.9 1.5 1 0 0 1 1 1 1 S1-like SAP PF02037.25 001108535.1_45729001_3 - 6.1e-09 35.3 1.5 6.1e-09 35.3 1.5 2.4 2 0 0 2 2 2 1 SAP domain Tautomerase_2 PF14552.4 001108535.1_45729001_3 - 0.096 12.7 0.0 0.3 11.1 0.0 1.8 1 0 0 1 1 1 0 Tautomerase enzyme FMO-like PF00743.17 001082285.2_37925001_1 - 9.4e-281 931.7 0.0 1.1e-280 931.5 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.4 001082285.2_37925001_1 - 5.4e-16 58.6 0.0 2.2e-11 43.4 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.4 001082285.2_37925001_1 - 2.7e-12 46.4 0.0 5.6e-10 38.7 0.0 2.9 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.12 001082285.2_37925001_1 - 3.9e-11 42.6 0.0 1.4e-09 37.5 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.4 001082285.2_37925001_1 - 3.6e-05 23.8 0.0 8.4e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 001082285.2_37925001_1 - 0.00015 21.4 0.0 0.77 9.2 0.0 2.9 3 0 0 3 3 3 2 FAD dependent oxidoreductase Pyr_redox PF00070.25 001082285.2_37925001_1 - 0.00027 21.3 0.6 0.8 10.2 0.2 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.4 001082285.2_37925001_1 - 0.0037 17.2 0.0 3.5 7.5 0.0 2.9 3 0 0 3 3 3 2 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.19 001082285.2_37925001_1 - 0.058 12.5 0.0 0.61 9.2 0.0 2.1 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.17 001082285.2_37925001_1 - 0.1 11.8 0.0 2 7.6 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Thi4 PF01946.15 001082285.2_37925001_1 - 0.16 11.0 0.0 1.7 7.7 0.0 2.1 2 0 0 2 2 2 0 Thi4 family NDUF_B4 PF07225.10 001071792.1_39721001_1 - 4.6e-62 207.3 0.1 5.1e-62 207.2 0.1 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) BTB_2 PF02214.20 001107253.1_45723001_1 - 1.6e-20 73.1 0.0 3.9e-20 71.9 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.3 001107253.1_45723001_1 - 0.00071 19.5 0.0 0.0018 18.3 0.0 1.7 2 0 0 2 2 2 1 BTB/POZ domain Sas10_Utp3 PF04000.13 001107263.1_45723001_1 - 5.1e-15 55.7 0.9 5.1e-15 55.7 0.9 2.7 2 1 0 3 3 3 1 Sas10/Utp3/C1D family RBR PF17208.1 001107263.1_45723001_1 - 0.011 16.4 2.7 0.033 14.8 2.7 1.8 1 0 0 1 1 1 0 RNA binding Region TRAF_BIRC3_bd PF16673.3 001107263.1_45723001_1 - 0.29 10.8 8.4 0.39 10.4 0.1 3.3 3 0 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain APG6 PF04111.10 001107263.1_45723001_1 - 4.2 6.5 12.1 0.77 9.0 6.7 2.0 2 0 0 2 2 2 0 Autophagy protein Apg6 IncA PF04156.12 001107263.1_45723001_1 - 5.7 6.5 12.9 1.6 8.4 2.6 2.7 3 0 0 3 3 3 0 IncA protein FAM176 PF14851.4 001107263.1_45723001_1 - 7 6.2 7.6 2.2 7.8 4.4 1.7 1 1 1 2 2 2 0 FAM176 family CH PF00307.29 001039963.1_39729001_2 - 4e-21 75.1 0.0 1.6e-20 73.2 0.0 2.1 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 001039963.1_39729001_2 - 9.5e-05 22.0 0.0 0.00021 20.9 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain Prefoldin_2 PF01920.18 001039963.1_39729001_2 - 0.0033 17.2 14.1 0.0033 17.2 14.1 7.1 5 1 2 7 7 7 2 Prefoldin subunit TPR_MLP1_2 PF07926.10 001039963.1_39729001_2 - 2.2 8.2 87.9 0.023 14.6 14.0 6.0 5 1 0 5 5 5 0 TPR/MLP1/MLP2-like protein Baculo_PEP_C PF04513.10 001039963.1_39729001_2 - 7 6.6 29.9 0.19 11.6 1.2 5.5 4 1 0 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus FEZ PF07763.11 005102.2_26225001_3 - 4.1e-93 311.4 9.3 7.3e-93 310.6 9.3 1.3 1 0 0 1 1 1 1 FEZ-like protein DUF5102 PF17104.3 005102.2_26225001_3 - 0.00021 21.3 2.3 0.45 10.4 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF5102) Gluconate_2-dh3 PF13618.4 005102.2_26225001_3 - 0.13 12.4 0.1 0.29 11.3 0.1 1.5 1 0 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 RNA_pol PF00940.17 001106766.1_45728001_3 - 7.2e-166 551.9 0.0 1.1e-165 551.4 0.0 1.3 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.4 001106766.1_45728001_3 - 6.2e-51 173.6 1.2 6.2e-51 173.6 1.2 2.3 2 0 0 2 2 2 1 DNA-directed RNA polymerase N-terminal NETI PF14044.4 001106766.1_45728001_3 - 0.0061 16.1 0.0 0.018 14.7 0.0 1.7 1 0 0 1 1 1 1 NETI protein HEAT PF02985.20 001083624.1_45729001_1 - 0.013 15.6 5.7 13 6.2 0.0 6.2 7 0 0 7 7 7 0 HEAT repeat Cnd1 PF12717.5 001083624.1_45729001_1 - 0.018 14.9 13.5 1.2 9.0 0.1 5.8 5 3 1 6 6 6 0 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.4 001083624.1_45729001_1 - 0.25 11.7 2.1 25 5.3 0.1 4.7 5 0 0 5 5 5 0 HEAT-like repeat EGF_CA PF07645.13 001108254.1_45726001_3 - 1e-22 79.9 37.0 1.6e-10 40.9 5.2 5.9 4 2 1 5 5 5 3 Calcium-binding EGF domain MAM PF00629.21 001108254.1_45726001_3 - 1.3e-16 60.7 0.0 2.3e-16 59.9 0.0 1.3 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu cEGF PF12662.5 001108254.1_45726001_3 - 8.7e-14 51.0 42.7 0.00016 21.4 0.3 6.6 6 0 0 6 6 6 5 Complement Clr-like EGF-like EGF_3 PF12947.5 001108254.1_45726001_3 - 4.2e-10 39.5 22.0 5.8e-10 39.1 11.3 6.2 5 1 0 5 5 5 3 EGF domain FXa_inhibition PF14670.4 001108254.1_45726001_3 - 9.6e-09 35.3 68.5 0.00087 19.4 9.7 6.1 3 1 2 5 5 5 4 Coagulation Factor Xa inhibitory site EGF PF00008.25 001108254.1_45726001_3 - 3.1e-06 27.2 77.9 0.0011 19.1 8.7 7.3 6 1 0 6 6 6 3 EGF-like domain hEGF PF12661.5 001108254.1_45726001_3 - 0.0057 17.1 3.3 0.0057 17.1 3.3 8.0 7 0 0 7 7 7 4 Human growth factor-like EGF EGF_2 PF07974.11 001108254.1_45726001_3 - 0.021 15.0 12.4 0.021 15.0 12.4 6.4 5 1 1 6 6 6 0 EGF-like domain C_tripleX PF02363.17 001108254.1_45726001_3 - 0.69 10.2 5.7 0.45 10.8 0.3 3.9 2 0 0 2 2 2 0 Cysteine rich repeat Homeobox PF00046.27 001081487.1_39722001_1 - 4.4e-24 83.9 3.8 6.1e-24 83.5 3.8 1.2 1 0 0 1 1 1 1 Homeobox domain 7tm_1 PF00001.19 001082331.1_37924001_2 - 2.1e-57 194.3 19.8 2.6e-57 193.9 19.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001082331.1_37924001_2 - 1.5e-10 40.8 19.1 1.9e-10 40.5 19.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001082331.1_37924001_2 - 0.0086 15.7 18.0 0.031 13.9 18.0 1.8 1 1 0 1 1 1 1 Olfactory receptor RUN PF02759.17 001083808.1_32924001_1 - 3e-19 69.2 0.1 5.5e-19 68.3 0.1 1.5 1 0 0 1 1 1 1 RUN domain SH3_9 PF14604.4 001083808.1_32924001_1 - 2e-10 40.2 0.0 3.8e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001083808.1_32924001_1 - 8.8e-09 34.7 0.0 1.8e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 001083808.1_32924001_1 - 1.1e-07 31.3 0.0 2.5e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Sec6 PF06046.11 001106178.1_45726001_3 - 1.2e-112 377.0 0.0 6.6e-112 374.6 0.0 1.9 1 1 0 1 1 1 1 Exocyst complex component Sec6 bZIP_Maf PF03131.15 001106178.1_45726001_3 - 7.4 7.0 6.5 14 6.1 1.3 3.0 3 0 0 3 3 3 0 bZIP Maf transcription factor NDUFV3 PF15880.3 001071813.1_39721001_1 - 1.5e-16 60.0 0.6 2.3e-16 59.4 0.6 1.3 1 0 0 1 1 1 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial Aldo_ket_red PF00248.19 001033697.1_45723001_1 - 1e-56 192.1 0.0 1.3e-56 191.8 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family SET PF00856.26 001025762.1_45724001_1 - 7.8e-16 58.8 0.4 2e-15 57.4 0.4 1.8 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.16 001025762.1_45724001_1 - 1.1e-09 38.1 13.2 1.1e-09 38.1 13.2 2.4 2 0 0 2 2 2 1 MYND finger Homeobox PF00046.27 001081569.1_39722001_1 - 5.9e-22 77.1 8.8 8.2e-22 76.7 8.8 1.2 1 0 0 1 1 1 1 Homeobox domain SR-25 PF10500.7 001081569.1_39722001_1 - 0.013 15.0 3.2 0.017 14.6 3.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DGF-1_C PF11040.6 001081569.1_39722001_1 - 0.065 13.1 0.7 0.065 13.1 0.7 1.8 2 0 0 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF2209 PF09974.7 001081569.1_39722001_1 - 0.081 13.1 0.1 0.11 12.6 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) Homeobox_KN PF05920.9 001081569.1_39722001_1 - 0.089 12.6 0.9 0.17 11.7 0.9 1.4 1 0 0 1 1 1 0 Homeobox KN domain HHH_2 PF12826.5 001109335.1_45724001_3 - 3.5e-12 46.1 0.0 6.1e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.4 001109335.1_45724001_3 - 0.0012 19.2 0.0 0.0022 18.5 0.0 1.3 1 0 0 1 1 1 1 Helix-hairpin-helix domain Rad10 PF03834.12 001109335.1_45724001_3 - 0.048 13.5 0.0 0.075 12.9 0.0 1.3 1 0 0 1 1 1 0 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH PF00633.21 001109335.1_45724001_3 - 0.087 12.6 0.2 15 5.6 0.1 2.6 2 1 0 2 2 2 0 Helix-hairpin-helix motif CIA30 PF08547.10 001106500.1_45723001_2 - 5.3e-48 162.9 0.2 7.2e-48 162.5 0.2 1.2 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) CBM_11 PF03425.11 001106500.1_45723001_2 - 0.00015 21.5 0.0 0.00026 20.8 0.0 1.3 1 0 0 1 1 1 1 Carbohydrate binding domain (family 11) FUN14 PF04930.13 001032900.1_29622001_1 - 4.6e-27 94.1 3.1 6.7e-27 93.6 3.1 1.3 1 0 0 1 1 1 1 FUN14 family Romo1 PF10247.7 001032900.1_29622001_1 - 0.083 13.1 3.9 3.8 7.8 0.1 2.4 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 PurA PF04845.11 152821.2_32923001_3 - 5.7e-109 362.4 0.1 7e-109 362.1 0.1 1.1 1 0 0 1 1 1 1 PurA ssDNA and RNA-binding protein PB1 PF00564.22 001108609.1_45727001_3 - 1.7e-15 56.6 0.0 3.1e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 PB1 domain PDZ PF00595.22 001108609.1_45727001_3 - 1.7e-10 41.0 0.0 2.8e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001108609.1_45727001_3 - 0.18 12.0 0.0 0.34 11.1 0.0 1.3 1 0 0 1 1 1 0 PDZ domain Pkinase PF00069.23 001082756.1_37929001_2 - 4.2e-72 242.5 0.0 6.3e-72 242.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001082756.1_37929001_2 - 2e-46 158.3 0.0 3.1e-46 157.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 001082756.1_37929001_2 - 3.9e-24 84.7 0.0 6.9e-24 83.9 0.0 1.4 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 001082756.1_37929001_2 - 6.9e-07 28.7 0.1 0.0015 17.8 0.0 2.2 1 1 1 2 2 2 2 Kinase-like APH PF01636.21 001082756.1_37929001_2 - 0.035 13.9 0.0 0.2 11.4 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.12 001082756.1_37929001_2 - 0.079 12.2 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HLH PF00010.24 001105970.1_45725001_1 - 5.9e-17 61.3 0.3 5.9e-17 61.3 0.3 2.1 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain UBA PF00627.29 001107620.1_45727001_1 - 0.0012 18.5 0.0 0.0023 17.7 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain His_Phos_1 PF00300.20 001107620.1_45727001_3 - 1.3e-18 67.2 0.0 4.6e-18 65.5 0.0 1.7 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) SH3_9 PF14604.4 001107620.1_45727001_3 - 3.4e-14 52.3 0.0 6.1e-14 51.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001107620.1_45727001_3 - 6.3e-05 22.4 0.0 0.00011 21.6 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 001107620.1_45727001_3 - 0.054 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain LAMTOR5 PF16672.3 001106462.1_45722001_1 - 3.1e-33 113.4 0.9 4.3e-33 113.0 0.9 1.2 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 WD40 PF00400.30 001106659.1_45726001_1 - 6.5e-40 134.3 19.2 1.1e-08 35.4 0.1 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat PRP4 PF08799.9 001106659.1_45726001_1 - 4.7e-14 51.5 0.7 4.7e-14 51.5 0.7 1.9 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like ANAPC4_WD40 PF12894.5 001106659.1_45726001_1 - 1.2e-13 51.0 0.0 0.011 15.9 0.0 4.9 4 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 001106659.1_45726001_1 - 0.00092 18.5 0.0 0.0026 17.0 0.0 1.7 2 0 0 2 2 2 1 WD40-like domain Ge1_WD40 PF16529.3 001106659.1_45726001_1 - 0.0015 17.5 1.6 1.3 7.8 0.2 3.8 2 2 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.6 001106659.1_45726001_1 - 0.2 10.1 1.7 5.6 5.3 0.0 3.4 2 2 2 4 4 4 0 Nucleoporin Nup120/160 DAGAT PF03982.11 001109370.1_45723001_3 - 2.5e-109 364.7 0.1 2.9e-109 364.4 0.1 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase HSR PF03172.11 001034137.1_45724001_2 - 4.7e-39 132.4 0.4 7.6e-39 131.7 0.4 1.3 1 0 0 1 1 1 1 HSR domain SAND PF01342.19 001034137.1_45724001_2 - 2.7e-28 97.4 1.6 5.1e-28 96.5 1.6 1.5 1 0 0 1 1 1 1 SAND domain Amnionless PF14828.4 001108061.1_45724001_1 - 8.1e-141 469.8 0.0 9.2e-141 469.6 0.0 1.0 1 0 0 1 1 1 1 Amnionless VWC PF00093.16 001108061.1_45724001_1 - 1 9.6 8.8 2.2 8.5 8.8 1.5 1 0 0 1 1 1 0 von Willebrand factor type C domain zf-C2H2 PF00096.24 001107813.1_45727001_1 - 2.7e-20 71.5 53.5 8.9e-05 22.6 1.1 9.4 9 0 0 9 9 9 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001107813.1_45727001_1 - 8.7e-17 60.2 53.4 0.0033 18.0 0.7 8.8 8 0 0 8 8 8 8 C2H2-type zinc finger zf-H2C2_2 PF13465.4 001107813.1_45727001_1 - 1.2e-07 31.7 0.3 1.2e-07 31.7 0.3 11.2 12 0 0 12 12 11 3 Zinc-finger double domain zf-H2C2_5 PF13909.4 001107813.1_45727001_1 - 4.4e-05 23.0 3.1 4.4e-05 23.0 3.1 8.7 11 1 0 11 11 10 2 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.4 001107813.1_45727001_1 - 0.0031 17.3 41.1 0.034 14.0 1.0 7.6 7 2 0 7 7 7 3 C2H2-type zinc finger zf-C2H2_2 PF12756.5 001107813.1_45727001_1 - 0.006 16.8 1.4 0.006 16.8 1.4 6.8 4 2 2 6 6 6 2 C2H2 type zinc-finger (2 copies) DUF629 PF04780.10 001107813.1_45727001_1 - 0.088 11.2 6.1 0.42 9.0 0.2 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF629) GAGA PF09237.9 001107813.1_45727001_1 - 0.11 12.2 1.6 1.2 8.8 0.2 3.3 3 0 0 3 3 3 0 GAGA factor Actin_micro PF17003.3 001107813.1_45727001_1 - 0.24 10.4 8.3 3.7 6.5 1.0 3.8 3 1 0 3 3 3 0 Putative actin-like family zinc_ribbon_15 PF17032.3 001107813.1_45727001_1 - 0.7 10.6 13.8 1.5 9.5 0.5 4.8 5 0 0 5 5 4 0 zinc-ribbon family zf-C2H2_8 PF15909.3 001107813.1_45727001_1 - 1.1 9.4 24.4 1.4 9.1 0.7 6.1 6 1 1 7 7 7 0 C2H2-type zinc ribbon C1_1 PF00130.20 001107813.1_45727001_1 - 2.5 7.9 19.4 0.28 11.0 0.8 4.3 5 0 0 5 5 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF3268 PF11672.6 001107813.1_45727001_1 - 3.4 7.9 6.9 13 6.0 1.8 2.7 2 0 0 2 2 2 0 zinc-finger-containing domain XPA_N PF01286.16 001107813.1_45727001_1 - 7 6.6 10.8 29 4.7 0.2 4.6 4 0 0 4 4 4 0 XPA protein N-terminal RNA_pol_Rpc4 PF05132.12 134349.3_45723001_1 - 0.016 15.5 21.0 0.022 15.1 21.0 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 Neur_chan_memb PF02932.14 134349.3_45723001_1 - 0.28 11.1 6.7 0.31 10.9 6.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RNA_pol_Rpc4 PF05132.12 134349.3_45723001_2 - 2.9e-05 24.4 10.3 3.7e-05 24.1 10.3 1.2 1 0 0 1 1 1 1 RNA polymerase III RPC4 DDHD PF02862.15 134349.3_45723001_2 - 0.66 9.9 13.4 0.85 9.6 13.4 1.1 1 0 0 1 1 1 0 DDHD domain Zip PF02535.20 134349.3_45723001_2 - 2.4 7.2 12.5 2.9 6.9 12.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4834 PF16118.3 134349.3_45723001_2 - 2.4 9.0 16.7 3.6 8.5 16.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Serinc PF03348.13 134349.3_45723001_2 - 6.8 5.4 7.3 8.2 5.1 7.3 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4569 PF15133.4 134349.3_45723001_2 - 8.8 5.8 16.0 11 5.5 16.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) MAPEG PF01124.16 134349.3_45723001_3 - 9.5e-26 90.1 0.1 9.5e-26 90.1 0.1 2.1 2 1 0 2 2 2 1 MAPEG family Vfa1 PF08432.8 134349.3_45723001_3 - 1.6 8.9 43.9 2.6 8.2 43.9 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 EOS1 PF12326.6 134349.3_45723001_3 - 2.7 7.7 13.4 6 6.6 13.4 1.6 1 0 0 1 1 1 0 N-glycosylation protein CobT PF06213.10 134349.3_45723001_3 - 6.5 5.9 12.6 9.6 5.4 12.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Mod_r PF07200.11 001105928.1_45726001_3 - 7.6e-37 126.5 9.2 9.7e-37 126.2 9.2 1.1 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein Ald_Xan_dh_C2 PF02738.16 001081990.1_37929001_2 - 5.6e-190 632.3 0.0 7.7e-190 631.8 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 001081990.1_37929001_2 - 1.3e-42 145.3 0.0 3.5e-42 143.9 0.0 1.7 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Fer2_2 PF01799.18 001081990.1_37929001_2 - 1.7e-31 107.8 0.1 4.3e-31 106.5 0.1 1.7 1 0 0 1 1 1 1 [2Fe-2S] binding domain Ald_Xan_dh_C PF01315.20 001081990.1_37929001_2 - 1.6e-30 105.6 0.5 3.3e-30 104.5 0.5 1.6 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.15 001081990.1_37929001_2 - 8e-28 96.5 0.0 2.6e-27 94.8 0.0 2.0 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.25 001081990.1_37929001_2 - 1.1e-09 37.9 0.3 4.6e-09 36.0 0.1 2.3 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Heme_oxygenase PF01126.18 001082747.1_37923001_3 - 2.5e-82 275.5 8.0 3.2e-82 275.2 8.0 1.1 1 0 0 1 1 1 1 Heme oxygenase WWE PF02825.18 001076980.1_06524001_1 - 2.7e-16 59.8 2.4 4.4e-16 59.0 2.4 1.4 1 0 0 1 1 1 1 WWE domain zf-C3HC4_3 PF13920.4 001076980.1_06524001_1 - 7.6e-07 28.8 10.7 1.7e-06 27.7 10.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001076980.1_06524001_1 - 0.00011 21.8 11.2 0.00028 20.6 11.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001076980.1_06524001_1 - 0.00012 22.1 12.6 0.00025 21.1 12.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.4 001076980.1_06524001_1 - 0.00014 21.6 9.1 0.00035 20.4 9.1 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 001076980.1_06524001_1 - 0.00082 19.0 12.0 0.0016 18.1 12.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 001076980.1_06524001_1 - 0.006 16.3 9.9 0.012 15.3 9.9 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 001076980.1_06524001_1 - 0.03 14.1 11.4 0.058 13.2 11.4 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_4 PF15227.4 001076980.1_06524001_1 - 0.05 13.6 12.8 0.029 14.4 10.6 1.8 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.3 001076980.1_06524001_1 - 0.058 13.4 7.5 0.12 12.3 7.5 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_11 PF17123.3 001076980.1_06524001_1 - 1.9 8.2 10.8 6.6 6.4 10.8 2.0 1 0 0 1 1 1 0 RING-like zinc finger fn3 PF00041.19 014759.3_26227001_3 - 0.0026 18.0 0.1 0.0053 16.9 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III domain Ribosomal_L50 PF10501.7 001108665.1_45724001_3 - 7.2e-12 45.3 0.0 1.2e-11 44.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal subunit 39S T-box PF00907.20 001108173.1_45729001_2 - 2.2e-79 265.8 0.0 4.4e-79 264.9 0.0 1.5 2 0 0 2 2 2 1 T-box Serpin PF00079.18 001107168.1_45724001_3 - 1.6e-116 389.6 0.4 1.8e-116 389.4 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Glyco_trans_4_3 PF12000.6 001107168.1_45724001_3 - 0.11 12.1 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Gkycosyl transferase family 4 group Snf7 PF03357.19 001108906.1_45722001_1 - 1.8e-46 157.8 23.5 2.5e-46 157.3 23.5 1.2 1 0 0 1 1 1 1 Snf7 DUF2570 PF10828.6 001108906.1_45722001_1 - 0.08 12.7 12.2 0.18 11.6 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) YlqD PF11068.6 001108906.1_45722001_1 - 1.5 9.1 16.6 0.12 12.6 5.4 2.2 1 1 1 2 2 2 0 YlqD protein dNK PF01712.17 001071805.1_39723001_1 - 3.7e-34 118.2 0.0 5e-34 117.8 0.0 1.1 1 0 0 1 1 1 1 Deoxynucleoside kinase Thymidylate_kin PF02223.15 001071805.1_39723001_1 - 0.0011 18.5 0.1 0.0026 17.3 0.1 1.6 1 1 0 1 1 1 1 Thymidylate kinase AAA_17 PF13207.4 001071805.1_39723001_1 - 0.0034 17.7 0.2 1.1 9.5 0.1 2.4 2 0 0 2 2 2 2 AAA domain Cytidylate_kin PF02224.16 001071805.1_39723001_1 - 0.022 14.4 0.0 0.045 13.4 0.0 1.5 1 0 0 1 1 1 0 Cytidylate kinase AAA_18 PF13238.4 001071805.1_39723001_1 - 0.05 14.0 0.0 0.32 11.4 0.0 2.2 1 1 0 1 1 1 0 AAA domain SKI PF01202.20 001071805.1_39723001_1 - 0.13 12.3 0.3 1.8 8.6 0.0 2.5 3 0 0 3 3 3 0 Shikimate kinase SBF PF01758.14 001082764.1_37923001_1 - 2e-47 161.3 17.2 2e-47 161.3 17.2 2.0 2 1 0 2 2 2 1 Sodium Bile acid symporter family Toxin_16 PF07945.9 001082764.1_37923001_1 - 3.2 7.6 8.4 0.69 9.7 1.9 2.3 2 0 0 2 2 2 0 Janus-atracotoxin AMP-binding PF00501.26 001107793.1_45726001_2 - 1.4e-97 326.8 0.0 1.7e-97 326.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 001107793.1_45726001_2 - 8e-25 87.5 0.1 1.5e-24 86.6 0.1 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.3 001107793.1_45726001_2 - 4.5e-19 68.0 0.5 1.3e-18 66.5 0.5 1.9 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus FGF-BP1 PF06473.10 001109165.1_45724001_3 - 1.1e-52 179.0 0.0 1.6e-52 178.5 0.0 1.2 1 0 0 1 1 1 1 FGF binding protein 1 (FGF-BP1) Ribosomal_L10 PF00466.18 001109620.1_45724001_1 - 0.0003 20.7 0.1 0.00049 20.0 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 PDZ PF00595.22 001105749.1_45729001_3 - 1.9e-49 165.8 2.5 5.5e-18 65.0 0.2 4.4 4 0 0 4 4 4 4 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001105749.1_45729001_3 - 5.6e-15 55.3 0.2 0.0065 16.6 0.0 4.5 4 0 0 4 4 4 4 PDZ domain Actin PF00022.17 001101683.1_37924001_1 - 6.6e-150 499.1 0.0 1.7e-149 497.8 0.0 1.6 1 1 0 1 1 1 1 Actin Ni_hydr_CYTB PF01292.18 001101683.1_37924001_3 - 0.014 14.8 0.1 0.026 14.0 0.1 1.3 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 DctQ PF04290.10 001101683.1_37924001_3 - 0.1 12.4 0.1 0.16 11.8 0.1 1.2 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporters, DctQ component Lectin_C PF00059.19 001085405.1_45722001_1 - 6.7e-15 55.6 0.2 9.6e-15 55.1 0.2 1.2 1 0 0 1 1 1 1 Lectin C-type domain Neurensin PF14927.4 001085405.1_45722001_1 - 0.046 13.3 0.2 0.087 12.4 0.2 1.5 1 1 0 1 1 1 0 Neurensin Proteasome PF00227.24 001025637.1_45723001_1 - 1.2e-47 161.8 0.0 1.4e-47 161.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.6 001025637.1_45723001_1 - 4.4e-12 45.1 0.1 9.4e-12 44.0 0.1 1.6 1 0 0 1 1 1 1 Proteasome beta subunits C terminal Ldl_recept_a PF00057.16 001082188.1_37927001_3 - 8e-105 342.6 158.1 1.1e-14 54.2 12.7 8.8 8 0 0 8 8 8 8 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.15 001082188.1_37927001_3 - 7.8e-67 221.4 8.5 3.5e-16 59.2 0.1 5.4 5 0 0 5 5 5 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 001082188.1_37927001_3 - 4.3e-18 65.2 36.5 3.3e-09 36.8 8.0 5.9 6 1 0 6 6 6 3 Coagulation Factor Xa inhibitory site cEGF PF12662.5 001082188.1_37927001_3 - 4.8e-08 32.7 35.0 2.8e-05 23.8 2.4 5.9 5 0 0 5 5 5 3 Complement Clr-like EGF-like EGF_CA PF07645.13 001082188.1_37927001_3 - 1e-07 31.9 6.0 1e-07 31.9 6.0 10.8 7 3 3 10 10 10 3 Calcium-binding EGF domain SGL PF08450.10 001082188.1_37927001_3 - 6.6e-05 22.5 0.6 0.18 11.2 0.3 2.8 1 1 1 2 2 2 2 SMP-30/Gluconolaconase/LRE-like region EGF PF00008.25 001082188.1_37927001_3 - 0.0026 17.9 3.1 0.0026 17.9 3.1 9.1 8 2 1 9 9 9 3 EGF-like domain DUF4859 PF16151.3 001082188.1_37927001_3 - 0.13 12.0 0.1 21 4.9 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4859) Tyrosinase PF00264.18 001107535.1_45727001_2 - 1.2e-41 143.3 0.6 1.7e-41 142.8 0.6 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase Laminin_EGF PF00053.22 001107535.1_45727001_2 - 0.043 13.8 9.6 0.11 12.5 4.6 2.9 2 0 0 2 2 2 0 Laminin EGF domain Peptidase_C1_2 PF03051.13 001034163.1_45725001_2 - 1.4e-207 689.6 1.3 1.6e-207 689.4 1.3 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.21 001034163.1_45725001_2 - 2.6e-05 24.3 0.2 0.048 13.6 0.2 2.3 2 0 0 2 2 2 2 Papain family cysteine protease Peptidase_S49_N PF08496.8 001108176.1_45724001_1 - 0.11 12.5 2.7 0.44 10.5 1.8 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal zf-C2H2 PF00096.24 001108176.1_45724001_2 - 1e-05 25.6 15.2 0.00031 20.9 5.2 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001108176.1_45724001_2 - 0.12 12.7 18.3 4.5 7.8 7.3 3.8 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_11 PF16622.3 001108176.1_45724001_2 - 0.96 9.1 5.5 0.49 10.1 2.4 2.2 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_4 PF13894.4 001108176.1_45724001_2 - 0.99 10.3 12.5 1.4 9.8 3.2 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger BCMA-Tall_bind PF09257.8 001105761.1_45722001_3 - 3.6e-17 62.0 13.6 3.6e-17 62.0 13.6 2.1 2 0 0 2 2 2 1 BCMA, TALL-1 binding TACI-CRD2 PF09305.8 001105761.1_45722001_3 - 0.006 16.4 7.5 0.015 15.2 7.5 1.7 1 0 0 1 1 1 1 TACI, cysteine-rich domain FMO-like PF00743.17 001082784.1_37925001_3 - 1.1e-275 914.9 0.0 1.3e-275 914.7 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.4 001082784.1_37925001_3 - 1.6e-15 57.0 0.0 1.4e-12 47.4 0.0 2.4 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.4 001082784.1_37925001_3 - 4.4e-11 42.4 0.0 2.1e-09 36.8 0.0 2.6 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.12 001082784.1_37925001_3 - 9.3e-08 31.5 0.0 1.2e-06 27.9 0.0 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.4 001082784.1_37925001_3 - 0.00015 21.8 0.0 0.00033 20.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 001082784.1_37925001_3 - 0.005 16.4 0.0 0.95 8.9 0.0 2.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.4 001082784.1_37925001_3 - 0.0077 16.1 0.0 0.053 13.4 0.0 2.4 2 1 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.25 001082784.1_37925001_3 - 0.016 15.6 0.3 4.7 7.7 0.3 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.19 001082784.1_37925001_3 - 0.1 11.7 0.0 0.5 9.5 0.0 1.9 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.15 001082784.1_37925001_3 - 0.12 11.5 0.1 0.54 9.3 0.0 1.9 2 0 0 2 2 2 0 Thi4 family 2-Hacid_dh_C PF02826.17 001082784.1_37925001_3 - 0.14 11.3 0.0 0.54 9.4 0.1 1.8 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF4205 PF13898.4 032222.2_26226001_3 - 1.8e-138 461.1 0.0 2.3e-138 460.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4205) Metallophos PF00149.26 001101707.1_37924001_1 - 1.3e-34 120.3 0.5 2.3e-34 119.6 0.5 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.3 001101707.1_37924001_1 - 0.014 15.7 1.2 0.023 15.0 0.3 1.8 2 0 0 2 2 2 0 Serine-threonine protein phosphatase N-terminal domain RAD51_interact PF15696.3 001079711.1_45725001_3 - 9.3e-14 51.1 6.9 9.3e-14 51.1 6.9 2.1 2 0 0 2 2 2 1 RAD51 interacting motif HSCB_C PF07743.11 001108340.1_45722001_2 - 3.8e-18 65.6 6.7 3.8e-18 65.6 6.7 1.9 2 1 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.29 001108340.1_45722001_2 - 5.2e-06 26.4 0.2 1.4e-05 25.0 0.2 1.7 1 0 0 1 1 1 1 DnaJ domain Peptidase_M48 PF01435.16 001107974.1_45725001_1 - 3.5e-71 238.9 0.0 4.9e-71 238.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M48 Peptidase_M48_N PF16491.3 001107974.1_45725001_1 - 1.5e-66 223.6 5.0 2.9e-66 222.7 5.0 1.5 1 0 0 1 1 1 1 CAAX prenyl protease N-terminal, five membrane helices Ion_trans PF00520.29 001101716.1_37929001_2 - 1.2e-244 807.2 79.0 5.7e-65 218.8 21.3 4.1 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.3 001101716.1_37929001_2 - 1e-35 121.2 0.0 2.8e-35 119.8 0.0 1.8 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 001101716.1_37929001_2 - 4.1e-28 97.3 0.2 9.2e-28 96.2 0.2 1.6 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 001101716.1_37929001_2 - 1.3e-09 37.1 21.0 4.3e-08 32.1 2.8 8.9 6 4 4 10 10 10 5 Polycystin cation channel Laminin_G_2 PF02210.22 001107432.1_45729001_3 - 2.4e-88 293.0 0.5 3.9e-24 85.5 0.1 4.4 4 0 0 4 4 4 4 Laminin G domain Laminin_G_1 PF00054.21 001107432.1_45729001_3 - 2.2e-59 199.2 0.0 2.4e-16 60.0 0.0 4.3 4 0 0 4 4 4 4 Laminin G domain F5_F8_type_C PF00754.23 001107432.1_45729001_3 - 5.2e-29 100.8 0.6 3.8e-28 98.0 0.1 2.5 2 0 0 2 2 2 1 F5/8 type C domain Laminin_G_3 PF13385.4 001107432.1_45729001_3 - 2.7e-11 43.7 0.0 9.7e-05 22.4 0.0 3.7 5 0 0 5 5 5 2 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.25 001107432.1_45729001_3 - 2.7e-05 24.3 35.9 0.00054 20.1 9.4 3.6 3 0 0 3 3 3 2 EGF-like domain COLFI PF01410.16 001107432.1_45729001_3 - 0.0065 15.7 0.1 0.63 9.2 0.1 2.4 2 0 0 2 2 2 1 Fibrillar collagen C-terminal domain MAP17 PF15807.3 001107432.1_45729001_3 - 0.18 11.9 0.1 0.32 11.1 0.1 1.3 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 GrpE PF01025.17 001109513.1_45725001_3 - 5.3e-37 126.9 0.0 7.3e-37 126.4 0.0 1.1 1 0 0 1 1 1 1 GrpE GOLGA2L5 PF15070.4 001109513.1_45725001_3 - 0.0023 16.5 0.0 0.0032 16.1 0.0 1.1 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 UPAR_LY6 PF00021.19 001109632.1_45723001_3 - 1.1e-05 25.9 34.9 0.0039 17.7 9.2 2.3 2 0 0 2 2 2 2 u-PAR/Ly-6 domain RabGAP-TBC PF00566.16 001105769.1_45728001_3 - 6.4e-29 101.0 0.0 9.4e-29 100.5 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain TLD PF07534.14 001105769.1_45728001_3 - 1.2e-25 90.2 0.3 2.7e-24 85.8 0.3 2.3 1 1 0 1 1 1 1 TLD zf-C2H2 PF00096.24 001034190.1_39729001_1 - 1.7e-19 69.0 29.7 0.00032 20.8 0.5 5.7 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001034190.1_39729001_1 - 2e-12 46.8 30.9 7.4e-07 29.2 1.4 5.3 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 001034190.1_39729001_1 - 1.7e-06 28.2 28.3 0.0045 17.6 0.3 5.8 5 0 0 5 5 5 3 C2H2-type zinc finger FOXP-CC PF16159.3 001034190.1_39729001_1 - 5e-06 26.9 20.6 0.022 15.2 4.8 5.0 1 1 2 4 4 4 2 FOXP coiled-coil domain zf-C2H2_aberr PF17017.3 001034190.1_39729001_1 - 1.4 8.9 15.6 10 6.1 2.3 3.4 2 1 1 3 3 3 0 Aberrant zinc-finger IL17 PF06083.9 001034190.1_39729001_1 - 3.8 7.9 6.6 0.49 10.8 0.2 2.9 3 0 0 3 3 3 0 Interleukin-17 V-ATPase_G PF03179.13 001105991.1_45724001_2 - 2.7e-33 114.5 11.4 3.5e-33 114.1 11.4 1.1 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit OmpH PF03938.12 001105991.1_45724001_2 - 2.2 8.1 13.8 3.3 7.6 13.8 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF883 PF05957.11 001105991.1_45724001_2 - 2.8 8.5 7.7 5.6 7.5 7.0 1.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Pro_isomerase PF00160.19 001032809.1_29621001_1 - 3.1e-47 160.6 0.2 3.5e-47 160.5 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PXA PF02194.13 001108708.1_45727001_1 - 1.6e-46 158.1 0.8 2.3e-45 154.3 0.3 2.5 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.10 001108708.1_45727001_1 - 1.2e-27 96.5 2.0 5e-27 94.6 0.1 3.1 3 0 0 3 3 3 1 Sorting nexin C terminal PX PF00787.22 001108708.1_45727001_1 - 5.7e-22 77.7 0.5 5.7e-22 77.7 0.5 2.0 2 0 0 2 2 2 1 PX domain RGS PF00615.17 001108708.1_45727001_1 - 8.4e-16 58.2 0.4 5.2e-14 52.4 0.0 3.2 3 0 0 3 3 3 1 Regulator of G protein signaling domain Swi3 PF07962.10 001108708.1_45727001_1 - 0.043 13.6 0.3 0.13 12.1 0.3 1.8 1 0 0 1 1 1 0 Replication Fork Protection Component Swi3 TetR_C_8 PF14278.4 001108708.1_45727001_1 - 0.18 12.0 1.0 1.9 8.8 0.0 3.2 3 0 0 3 3 3 0 Transcriptional regulator C-terminal region CD20 PF04103.13 001082050.1_37925001_3 - 3.1e-26 92.2 18.1 5.6e-26 91.3 18.1 1.5 1 0 0 1 1 1 1 CD20-like family Sensor PF13796.4 001082050.1_37925001_3 - 4.1 7.3 18.1 1.1 9.1 0.1 2.5 1 1 1 2 2 2 0 Putative sensor ABC_membrane_2 PF06472.13 001108821.1_45727001_3 - 2e-99 332.4 3.0 2.6e-99 332.0 3.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.25 001108821.1_45727001_3 - 4.1e-15 56.4 0.0 7.1e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.4 001108821.1_45727001_3 - 0.00099 18.9 0.0 0.0019 17.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.4 001108821.1_45727001_3 - 0.02 15.3 0.1 0.02 15.3 0.1 1.6 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.4 001108821.1_45727001_3 - 0.028 14.0 0.0 0.06 12.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Adeno_IVa2 PF02456.13 001108821.1_45727001_3 - 0.078 11.6 0.7 0.18 10.5 0.2 1.7 2 0 0 2 2 2 0 Adenovirus IVa2 protein SMC_N PF02463.17 001108821.1_45727001_3 - 0.12 11.7 0.0 0.5 9.6 0.0 1.8 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Rad17 PF03215.13 001108821.1_45727001_3 - 0.22 10.3 0.0 0.33 9.7 0.0 1.1 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein Kelch_1 PF01344.23 001109257.1_45727001_1 - 7.4e-29 99.0 0.3 1e-08 34.5 0.0 4.8 4 0 0 4 4 4 4 Kelch motif Kelch_6 PF13964.4 001109257.1_45727001_1 - 1.5e-23 82.0 0.4 5.7e-07 29.5 0.0 5.8 4 1 1 5 5 5 4 Kelch motif Kelch_3 PF13415.4 001109257.1_45727001_1 - 2.1e-12 46.9 0.4 3.4e-06 27.1 0.0 4.8 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.13 001109257.1_45727001_1 - 9.4e-12 44.3 1.6 0.024 14.5 0.0 6.0 6 1 0 6 6 6 4 Kelch motif Kelch_5 PF13854.4 001109257.1_45727001_1 - 1e-09 38.0 0.1 9.1e-05 22.2 0.0 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.4 001109257.1_45727001_1 - 5e-06 26.2 1.3 0.29 11.0 0.0 4.6 5 0 0 5 5 5 2 Galactose oxidase, central domain BTB PF00651.29 001109257.1_45727001_1 - 0.00041 20.4 0.0 0.022 14.8 0.0 2.4 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.13 001109257.1_45727001_1 - 0.0026 17.7 0.0 0.0058 16.6 0.0 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch KH_1 PF00013.27 001039337.1_45724001_1 - 9.9e-70 230.2 16.6 7.2e-19 67.2 0.6 4.2 4 0 0 4 4 4 4 KH domain KH_2 PF07650.15 001039337.1_45724001_1 - 4.5e-20 71.1 9.9 1.9e-05 24.3 0.0 4.3 4 0 0 4 4 4 4 KH domain KH_4 PF13083.4 001039337.1_45724001_1 - 1.6e-11 43.8 9.2 0.032 14.0 0.1 4.4 4 0 0 4 4 4 4 KH domain DUF1897 PF09005.8 001039337.1_45724001_1 - 2.6e-10 39.5 13.3 3e-06 26.5 2.3 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF1897) KH_5 PF13184.4 001039337.1_45724001_1 - 0.019 14.9 11.9 2.8 8.0 0.2 4.4 4 0 0 4 4 4 0 NusA-like KH domain 3HCDH_N PF02737.16 001082278.1_37923001_1 - 1.9e-50 171.1 0.0 2.5e-50 170.7 0.0 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.20 001082278.1_37923001_1 - 2.8e-16 59.8 0.0 5.9e-16 58.7 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_8 PF13450.4 001082278.1_37923001_1 - 0.06 13.5 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_Gly3P_dh_N PF01210.21 001082278.1_37923001_1 - 0.061 13.2 0.0 0.096 12.5 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.17 001082278.1_37923001_1 - 0.086 12.0 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.12 001082278.1_37923001_1 - 0.096 12.1 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.13 001082278.1_37923001_1 - 0.15 12.1 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase E1-E2_ATPase PF00122.18 001089321.1_37929001_1 - 3e-64 216.2 1.3 3e-64 216.2 1.3 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 001089321.1_37929001_1 - 3.8e-46 157.0 2.1 9.3e-46 155.7 2.1 1.7 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 001089321.1_37929001_1 - 4e-21 74.8 0.5 7.5e-21 73.9 0.5 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 001089321.1_37929001_1 - 3.2e-18 66.7 0.1 2.7e-17 63.6 0.1 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 001089321.1_37929001_1 - 9.5e-17 60.3 0.9 4.8e-16 58.0 0.1 2.4 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 001089321.1_37929001_1 - 1.2e-05 25.1 0.6 2.3e-05 24.2 0.6 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 001089321.1_37929001_1 - 0.00026 21.3 0.0 0.001 19.3 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HSP20 PF00011.19 001108835.1_45722001_1 - 6.5e-11 42.2 0.0 1.2e-10 41.3 0.0 1.4 1 1 0 1 1 1 1 Hsp20/alpha crystallin family Cementoin PF10511.7 001108835.1_45722001_1 - 0.039 13.8 0.1 0.75 9.7 0.0 2.7 2 0 0 2 2 2 0 Trappin protein transglutaminase binding domain RFX5_DNA_bdg PF14621.4 001107694.1_45729001_2 - 1.8e-108 361.2 19.9 3.5e-108 360.3 19.9 1.5 1 0 0 1 1 1 1 RFX5 DNA-binding domain RFX_DNA_binding PF02257.13 001107694.1_45729001_2 - 3.3e-28 98.0 0.9 6.1e-28 97.1 0.9 1.4 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.14 001107694.1_45729001_2 - 0.0047 17.3 0.0 0.01 16.2 0.0 1.4 1 0 0 1 1 1 1 Poxvirus D5 protein-like AT_hook PF02178.17 001107694.1_45729001_2 - 3.6 7.7 9.7 13 5.9 9.7 2.1 1 0 0 1 1 1 0 AT hook motif KRTAP PF11759.6 001107694.1_45729001_3 - 7 7.1 32.2 1.6e+04 -5.8 32.2 2.6 1 1 0 1 1 1 0 Keratin-associated matrix Aph-1 PF06105.10 001047090.1_45723001_3 - 1.4e-86 289.6 16.2 1.7e-86 289.2 16.2 1.1 1 0 0 1 1 1 1 Aph-1 protein Pou PF00157.15 017252.2_45723001_3 - 1.4e-38 130.6 0.3 2.3e-38 129.9 0.3 1.4 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 017252.2_45723001_3 - 3.5e-18 65.0 1.5 9.5e-18 63.6 0.3 2.1 2 0 0 2 2 2 1 Homeobox domain HTH_31 PF13560.4 017252.2_45723001_3 - 0.021 15.0 0.0 0.082 13.1 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain Homeobox_KN PF05920.9 017252.2_45723001_3 - 0.064 13.0 0.2 0.19 11.5 0.0 1.9 2 0 0 2 2 2 0 Homeobox KN domain Lys PF00062.18 001077829.1_06523001_2 - 4.8e-56 188.2 4.1 7.4e-56 187.6 4.1 1.3 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family SLT PF01464.18 001077829.1_06523001_2 - 0.0019 17.7 0.0 0.0034 16.9 0.0 1.3 1 0 0 1 1 1 1 Transglycosylase SLT domain Acetyltransf_2 PF00797.15 001037316.1_45724001_2 - 3.1e-90 302.0 0.3 4.2e-90 301.6 0.3 1.2 1 0 0 1 1 1 1 N-acetyltransferase AIG1 PF04548.14 001011968.3_45723001_1 - 2e-71 239.5 0.0 2.7e-71 239.1 0.0 1.1 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.21 001011968.3_45723001_1 - 6.1e-08 32.6 0.0 9.9e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.21 001011968.3_45723001_1 - 0.042 13.8 1.2 0.18 11.8 0.4 2.1 1 1 1 2 2 2 0 Dynamin family Septin PF00735.16 001011968.3_45723001_1 - 0.099 11.7 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Septin ABC_tran PF00005.25 001011968.3_45723001_1 - 0.1 13.0 0.0 0.17 12.3 0.0 1.4 1 1 0 1 1 1 0 ABC transporter FeoB_N PF02421.16 001011968.3_45723001_1 - 0.1 12.0 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_29 PF13555.4 001011968.3_45723001_1 - 0.11 12.2 0.3 0.21 11.2 0.3 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSE PF00437.18 001011968.3_45723001_1 - 0.14 11.0 0.0 0.22 10.4 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein G-alpha PF00503.18 001011968.3_45723001_1 - 0.26 10.3 0.6 0.52 9.3 0.1 1.6 2 0 0 2 2 2 0 G-protein alpha subunit Ion_trans PF00520.29 001106101.1_45723001_3 - 2.6e-28 98.8 22.0 3.9e-28 98.2 22.0 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.10 001106101.1_45723001_3 - 1.3e-05 24.0 8.3 1.3e-05 24.0 8.3 2.1 2 0 0 2 2 2 2 Polycystin cation channel Xylo_C PF12529.6 001106101.1_45723001_3 - 0.028 13.9 0.6 6.8 6.1 0.0 2.2 2 0 0 2 2 2 0 Xylosyltransferase C terminal EphA2_TM PF14575.4 001106101.1_45723001_3 - 1.1 10.0 3.6 6.5 7.5 0.0 3.5 4 0 0 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain BEX PF04538.10 001006938.2_26224001_3 - 2.6e-43 147.4 35.7 6.8e-40 136.4 17.1 2.1 1 1 1 2 2 2 2 Brain expressed X-linked like family PMP22_Claudin PF00822.18 001102364.1_45724001_3 - 6.1e-32 110.7 10.8 9.9e-32 110.0 10.8 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001102364.1_45724001_3 - 4.5e-07 29.7 12.4 4.5e-07 29.7 12.4 2.9 2 1 0 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction DUF202 PF02656.13 001102364.1_45724001_3 - 3.1 8.2 9.8 8.2 6.8 1.8 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF202) Borrelia_P13 PF05628.10 001102364.1_45724001_3 - 5.5 6.8 8.6 0.52 10.1 0.5 2.8 2 1 1 3 3 3 0 Borrelia membrane protein P13 V-set PF07686.15 001105972.1_45724001_2 - 3.2e-22 78.6 0.6 1.3e-13 50.9 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.4 001105972.1_45724001_2 - 1e-14 54.8 0.1 4e-09 36.8 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001105972.1_45724001_2 - 7.4e-11 41.8 0.2 1.6e-05 24.7 0.0 2.7 2 2 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 001105972.1_45724001_2 - 3.7e-08 33.4 2.1 0.00013 22.1 0.2 3.8 2 2 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001105972.1_45724001_2 - 7.5e-06 25.9 0.0 0.2 11.7 0.1 2.9 2 2 0 2 2 2 2 Immunoglobulin domain Izumo-Ig PF16706.3 001105972.1_45724001_2 - 0.11 12.5 0.2 3.6 7.6 0.0 2.4 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain Tom22 PF04281.11 212514.2_45723001_2 - 2.2e-12 46.8 0.2 3.1e-12 46.3 0.2 1.1 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 fn3 PF00041.19 001107030.1_45725001_3 - 1.3e-07 31.8 0.0 2.4e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain CH_2 PF06294.9 001044561.1_49829001_1 - 1.1e-23 83.0 1.5 1.9e-22 79.1 0.0 2.9 2 0 0 2 2 2 1 CH-like domain in sperm protein ADK PF00406.20 001044561.1_49829001_1 - 1.6e-09 37.9 5.8 2.4e-09 37.3 0.0 3.9 4 1 0 4 4 4 1 Adenylate kinase Hydin_ADK PF17213.1 001044561.1_49829001_1 - 0.00019 21.6 0.6 0.00019 21.6 0.6 4.6 5 1 1 6 6 6 1 Hydin Adenylate kinase-like domain AAA_17 PF13207.4 001044561.1_49829001_1 - 0.13 12.5 0.0 0.13 12.5 0.0 4.8 4 1 1 5 5 5 0 AAA domain NDUFA12 PF05071.14 001071784.1_39721001_1 - 1.9e-30 105.4 5.7 2.3e-30 105.1 5.7 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 SPRY PF00622.26 001037765.1_45724001_1 - 2.1e-08 34.2 0.0 3.3e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 SPRY domain PRY PF13765.4 001037765.1_45724001_1 - 4.7e-05 22.8 0.0 8.2e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 SPRY-associated domain Oxysterol_BP PF01237.16 001108927.1_45729001_2 - 2.1e-146 487.4 0.5 3.8e-146 486.5 0.5 1.4 1 0 0 1 1 1 1 Oxysterol-binding protein PH PF00169.27 001108927.1_45729001_2 - 1.4e-15 57.6 0.1 3.4e-15 56.3 0.1 1.7 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 001108927.1_45729001_2 - 1.9e-11 43.9 0.3 3.7e-11 43.0 0.3 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.4 001108927.1_45729001_2 - 3.6e-05 23.9 0.0 0.00012 22.2 0.0 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.4 001108927.1_45729001_2 - 7.6e-05 23.0 4.0 0.0049 17.1 4.0 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain betaPIX_CC PF16523.3 001108927.1_45729001_2 - 0.055 13.2 0.4 0.16 11.7 0.4 1.7 1 0 0 1 1 1 0 betaPIX coiled coil Syntaxin-6_N PF09177.9 001108927.1_45729001_2 - 0.36 11.3 5.2 0.55 10.7 2.4 2.4 2 0 0 2 2 2 0 Syntaxin 6, N-terminal EF-hand_7 PF13499.4 001082645.1_37922001_2 - 7.8e-31 106.2 8.4 1.1e-17 64.1 3.6 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 001082645.1_37922001_2 - 8.6e-30 99.9 20.5 3.3e-08 32.4 0.7 4.2 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.4 001082645.1_37922001_2 - 4.7e-25 87.0 16.8 2.4e-13 49.5 0.5 3.6 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.4 001082645.1_37922001_2 - 3.4e-24 82.5 11.9 7.6e-07 28.4 0.0 4.4 4 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.4 001082645.1_37922001_2 - 7.1e-21 72.6 17.5 1.5e-05 24.1 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.4 001082645.1_37922001_2 - 7.5e-16 58.1 0.5 1.8e-07 31.3 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 001082645.1_37922001_2 - 3e-07 30.2 5.6 0.0036 17.1 0.3 3.0 1 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 001082645.1_37922001_2 - 1.2e-06 28.7 0.3 0.00043 20.4 0.3 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.9 001082645.1_37922001_2 - 0.0013 19.4 0.0 1.4 9.7 0.0 2.1 1 1 1 2 2 2 2 EF-hand domain DUF1456 PF07308.11 001082645.1_37922001_2 - 0.0015 18.8 0.8 0.13 12.5 0.1 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF1456) TerB PF05099.11 001082645.1_37922001_2 - 0.0016 18.3 1.9 0.3 10.9 0.8 2.2 1 1 1 2 2 2 2 Tellurite resistance protein TerB p25-alpha PF05517.10 001082645.1_37922001_2 - 0.022 14.8 0.4 0.23 11.5 0.1 2.1 1 1 1 2 2 2 0 p25-alpha SurA_N_2 PF13623.4 001082645.1_37922001_2 - 0.055 13.2 0.2 0.11 12.2 0.2 1.6 1 1 0 1 1 1 0 SurA N-terminal domain Caleosin PF05042.11 001082645.1_37922001_2 - 0.055 13.2 1.7 13 5.6 0.1 3.6 1 1 2 3 3 3 0 Caleosin related protein DUF533 PF04391.10 001082645.1_37922001_2 - 0.12 11.8 2.6 0.12 11.8 0.3 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF533) EBP50_C PF09007.9 001082345.1_37924001_1 - 1e-40 139.6 8.5 1e-40 139.6 8.5 1.8 2 0 0 2 2 2 1 EBP50, C-terminal PDZ PF00595.22 001082345.1_37924001_1 - 2e-29 101.6 0.1 1.6e-13 50.6 0.0 2.3 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001082345.1_37924001_1 - 5.6e-15 55.3 0.1 1.2e-06 28.6 0.0 2.3 2 0 0 2 2 2 2 PDZ domain GRASP55_65 PF04495.12 001082345.1_37924001_1 - 0.00068 19.8 0.0 1.2 9.4 0.0 2.2 2 0 0 2 2 2 2 GRASP55/65 PDZ-like domain Tricorn_PDZ PF14685.4 001082345.1_37924001_1 - 0.021 14.7 0.2 2.5 8.1 0.0 2.6 2 0 0 2 2 2 0 Tricorn protease PDZ domain Peptidase_M10 PF00413.22 001082495.2_21024001_3 - 1e-61 207.2 0.0 1.9e-61 206.4 0.0 1.4 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 001082495.2_21024001_3 - 6.5e-49 163.5 17.4 6.7e-16 57.8 0.7 4.4 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.16 001082495.2_21024001_3 - 3.9e-10 39.7 0.1 7.5e-10 38.7 0.1 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.22 001082495.2_21024001_3 - 0.0012 18.4 0.2 0.25 10.8 0.1 2.5 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.4 001082495.2_21024001_3 - 0.016 15.6 0.0 0.026 14.9 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 001082495.2_21024001_3 - 0.055 13.0 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.4 001082495.2_21024001_3 - 0.12 12.4 0.1 0.19 11.7 0.1 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12 DUF4953 PF16313.3 001082495.2_21024001_3 - 0.16 11.0 0.2 0.3 10.1 0.2 1.3 1 0 0 1 1 1 0 Met-zincin ANAPC10 PF03256.14 001108445.1_45723001_2 - 5.3e-81 270.6 0.1 7.1e-81 270.1 0.1 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.23 001108445.1_45723001_2 - 0.00035 20.6 0.1 0.00056 19.9 0.1 1.2 1 0 0 1 1 1 1 F5/8 type C domain PITH PF06201.11 001108445.1_45723001_2 - 0.013 15.6 0.1 0.04 14.0 0.1 1.6 1 1 1 2 2 2 0 PITH domain Homeobox PF00046.27 001081481.1_39722001_1 - 4.2e-20 71.2 7.0 8.4e-20 70.2 7.0 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001081481.1_39722001_1 - 0.035 13.9 0.2 0.075 12.8 0.2 1.6 1 0 0 1 1 1 0 Homeobox KN domain PHD PF00628.27 001106447.1_45726001_1 - 3.7e-07 29.8 5.4 7.8e-07 28.8 5.4 1.6 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.4 001106447.1_45726001_1 - 0.0012 18.6 0.8 0.0025 17.6 0.8 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 zf-RING_2 PF13639.4 001106447.1_45726001_1 - 0.036 14.2 3.9 0.13 12.5 3.9 2.0 1 0 0 1 1 1 0 Ring finger domain hDGE_amylase PF14701.4 001082247.1_37929001_2 - 1.7e-163 544.7 0.0 2.3e-163 544.2 0.0 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.12 001082247.1_37929001_2 - 1e-141 472.2 0.0 1.5e-141 471.6 0.0 1.3 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.4 001082247.1_37929001_2 - 3.8e-86 288.9 0.0 6.5e-86 288.1 0.0 1.4 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.4 001082247.1_37929001_2 - 2.2e-19 69.2 0.0 4e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.22 001082247.1_37929001_2 - 0.012 15.0 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Alpha amylase, catalytic domain Complex1_LYR PF05347.13 001071799.1_39722001_1 - 9.5e-12 44.7 3.3 9.5e-12 44.7 3.3 1.8 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.4 001071799.1_39722001_1 - 0.00011 22.7 1.5 0.00011 22.7 1.5 1.5 2 0 0 2 2 2 1 Complex1_LYR-like ImpA_N PF06812.10 001071799.1_39722001_1 - 0.017 15.1 0.4 0.049 13.6 0.0 1.9 1 1 1 2 2 2 0 ImpA, N-terminal, type VI secretion system TIR PF01582.18 001032960.1_29624001_2 - 5.2e-40 137.0 0.1 7.5e-40 136.4 0.1 1.2 1 0 0 1 1 1 1 TIR domain Ig_3 PF13927.4 001032960.1_29624001_2 - 5.1e-15 55.7 1.8 2.1e-07 31.3 0.1 3.7 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 001032960.1_29624001_2 - 4.6e-11 42.8 1.0 5.8e-05 23.2 0.2 3.5 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 001032960.1_29624001_2 - 2.8e-08 33.6 0.1 0.34 10.9 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.23 001032960.1_29624001_2 - 3.1e-08 33.5 4.6 0.058 13.4 0.0 4.5 4 1 0 4 4 4 2 Immunoglobulin domain TIR_2 PF13676.4 001032960.1_29624001_2 - 0.0049 17.1 0.0 0.0094 16.1 0.0 1.5 1 0 0 1 1 1 1 TIR domain V-set PF07686.15 001032960.1_29624001_2 - 0.011 15.8 1.5 15 5.7 0.0 3.9 3 2 0 3 3 3 0 Immunoglobulin V-set domain DEAD PF00270.27 001047143.1_29623001_1 - 2.4e-39 134.8 0.1 4e-39 134.0 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001047143.1_29623001_1 - 3.1e-25 88.6 0.5 9.2e-23 80.6 0.1 2.5 2 1 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.13 001047143.1_29623001_1 - 7.3e-08 32.5 0.0 1.2e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.4 001047143.1_29623001_1 - 1.2e-06 27.9 0.1 2.5e-06 26.9 0.1 1.5 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit zf-C2H2 PF00096.24 001106666.1_45729001_1 - 5.9e-10 38.9 32.8 0.0052 17.0 1.8 7.5 6 0 0 6 6 6 4 Zinc finger, C2H2 type zf-met PF12874.5 001106666.1_45729001_1 - 1.5e-06 28.3 20.9 0.0081 16.4 0.1 5.4 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 001106666.1_45729001_1 - 0.0011 19.0 19.1 0.49 10.6 1.5 5.1 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.4 001106666.1_45729001_1 - 0.0094 16.6 1.1 0.0094 16.6 1.1 8.4 9 0 0 9 9 9 3 C2H2-type zinc finger PID PF00640.21 001108065.1_45728001_1 - 9e-46 155.2 0.0 1.2e-45 154.8 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH2 PF00017.22 001108065.1_45728001_1 - 3.9e-16 58.7 0.0 6e-16 58.1 0.0 1.3 1 0 0 1 1 1 1 SH2 domain FCH PF00611.21 001009966.2_45724001_1 - 2.7e-16 59.4 1.7 2.8e-16 59.4 0.1 1.8 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.4 001009966.2_45724001_1 - 1.1e-14 53.9 0.1 2.2e-14 52.9 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001009966.2_45724001_1 - 2.9e-12 45.9 1.8 3.2e-12 45.7 0.0 2.1 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.15 001009966.2_45724001_1 - 1.3e-06 27.8 0.0 3.4e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SHE3 PF17078.3 001009966.2_45724001_1 - 0.1 12.2 6.7 0.16 11.6 6.7 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 GrpE PF01025.17 001009966.2_45724001_1 - 0.17 11.4 8.6 0.049 13.2 4.7 1.9 1 1 1 2 2 2 0 GrpE Tho2 PF11262.6 001009966.2_45724001_1 - 0.21 10.6 5.4 0.31 10.1 5.4 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF3450 PF11932.6 001009966.2_45724001_1 - 0.54 9.4 8.6 0.84 8.7 8.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) IncA PF04156.12 001009966.2_45724001_1 - 1.9 8.1 9.0 4.7 6.8 9.0 1.7 1 0 0 1 1 1 0 IncA protein Mnd1 PF03962.13 001009966.2_45724001_1 - 3.4 7.4 10.6 5.9 6.6 10.6 1.3 1 0 0 1 1 1 0 Mnd1 family APG6 PF04111.10 001009966.2_45724001_1 - 4.8 6.4 11.1 7.2 5.8 11.1 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Neurexophilin PF06312.10 012994.2_45725001_3 - 2.8e-111 369.9 2.4 4e-111 369.4 2.4 1.2 1 0 0 1 1 1 1 Neurexophilin Ribosomal_L22 PF00237.17 001105781.1_45722001_3 - 7.6e-28 96.8 0.5 1.2e-27 96.1 0.1 1.5 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e Trypsin PF00089.24 001082679.1_37924001_1 - 9.9e-61 205.2 0.0 1.4e-60 204.7 0.0 1.2 1 0 0 1 1 1 1 Trypsin Gla PF00594.18 001082679.1_37924001_1 - 5.3e-19 68.0 5.7 5.3e-19 68.0 5.7 2.0 2 0 0 2 2 2 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain DUF1986 PF09342.9 001082679.1_37924001_1 - 1.3e-08 35.1 0.0 2.8e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) FXa_inhibition PF14670.4 001082679.1_37924001_1 - 4.3e-08 33.2 10.8 4.3e-08 33.2 10.8 2.9 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site EGF PF00008.25 001082679.1_37924001_1 - 3.3e-06 27.2 18.0 5.5e-06 26.4 5.7 2.9 2 0 0 2 2 2 2 EGF-like domain cEGF PF12662.5 001082679.1_37924001_1 - 0.00012 21.8 1.5 0.00012 21.8 1.5 3.4 3 1 0 3 3 3 1 Complement Clr-like EGF-like hEGF PF12661.5 001082679.1_37924001_1 - 0.00018 22.0 14.8 0.001 19.5 2.5 3.4 2 0 0 2 2 2 2 Human growth factor-like EGF EamA PF00892.18 001107522.1_45726001_2 - 0.0062 16.6 15.0 0.0062 16.6 15.0 2.6 3 0 0 3 3 3 2 EamA-like transporter family Globin PF00042.20 001035508.1_39721001_1 - 4.9e-15 55.9 0.0 6.4e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 Globin F-box-like PF12937.5 001107672.1_45724001_1 - 1.4e-05 24.8 1.2 1.4e-05 24.8 1.2 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.31 001107672.1_45724001_1 - 0.00065 19.4 0.1 0.0018 18.0 0.1 1.8 1 0 0 1 1 1 1 F-box domain PRANC PF09372.8 001107672.1_45724001_1 - 0.036 14.3 0.0 0.097 12.9 0.0 1.7 1 0 0 1 1 1 0 PRANC domain Arf PF00025.19 001107672.1_45724001_1 - 0.096 12.0 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family Forkhead PF00250.16 012560.2_45726001_1 - 1.3e-38 131.0 1.2 1.7e-38 130.6 0.1 1.8 2 0 0 2 2 2 1 Forkhead domain SelP_N PF04592.12 012560.2_45726001_1 - 2.5 7.3 19.6 3.4 6.9 18.1 1.7 2 0 0 2 2 2 0 Selenoprotein P, N terminal region CH PF00307.29 001048155.1_22424001_2 - 3.4e-11 43.2 0.0 5.3e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 001048155.1_22424001_2 - 0.0018 17.9 0.0 0.0039 16.9 0.0 1.5 1 0 0 1 1 1 1 CAMSAP CH domain CDC24 PF06395.9 001048155.1_22424001_2 - 0.0023 18.1 0.0 0.0043 17.2 0.0 1.5 1 0 0 1 1 1 1 CDC24 Calponin Tropomyosin PF00261.18 001097483.2_49823001_2 - 6.1e-100 333.3 83.5 5.6e-97 323.6 60.0 2.0 1 1 1 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.5 001097483.2_49823001_2 - 1.1e-39 135.7 69.7 1.4e-35 122.4 39.3 3.0 2 1 0 2 2 2 2 Tropomyosin like CLZ PF16526.3 001097483.2_49823001_2 - 1.3e-05 25.3 46.3 0.00068 19.8 9.6 4.8 2 2 2 5 5 5 3 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Laminin_II PF06009.10 001097483.2_49823001_2 - 3.9e-05 23.6 37.1 9.8e-05 22.3 6.4 4.1 1 1 3 4 4 4 2 Laminin Domain II IncA PF04156.12 001097483.2_49823001_2 - 0.001 18.8 22.2 0.001 18.8 22.2 2.9 1 1 2 3 3 3 1 IncA protein TMF_DNA_bd PF12329.6 001097483.2_49823001_2 - 0.0015 18.4 9.8 0.0015 18.4 9.8 6.2 1 1 4 6 6 6 2 TATA element modulatory factor 1 DNA binding DUF1664 PF07889.10 001097483.2_49823001_2 - 0.011 15.5 26.5 0.06 13.2 3.3 3.7 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.7 001097483.2_49823001_2 - 0.015 15.2 61.7 0.013 15.4 28.9 2.3 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 XhlA PF10779.7 001097483.2_49823001_2 - 0.026 14.6 2.4 0.026 14.6 2.4 6.5 2 2 6 8 8 8 0 Haemolysin XhlA DUF745 PF05335.11 001097483.2_49823001_2 - 0.03 13.9 46.2 0.24 11.0 8.3 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF745) AAA_13 PF13166.4 001097483.2_49823001_2 - 0.032 12.8 46.7 0.6 8.6 14.6 2.1 1 1 1 2 2 2 0 AAA domain MscS_porin PF12795.5 001097483.2_49823001_2 - 0.19 11.1 48.0 3.8 6.9 28.3 3.0 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Alanine_zipper PF11839.6 001097483.2_49823001_2 - 0.31 11.2 49.0 0.088 13.0 2.4 4.8 1 1 2 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein DUF16 PF01519.14 001097483.2_49823001_2 - 0.44 10.9 35.8 0.68 10.3 0.4 4.4 1 1 3 4 4 4 0 Protein of unknown function DUF16 ERM PF00769.17 001097483.2_49823001_2 - 0.49 10.0 70.0 0.44 10.2 23.2 3.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Laminin_I PF06008.12 001097483.2_49823001_2 - 0.72 9.4 51.8 1.8 8.1 15.6 3.2 1 1 2 3 3 3 0 Laminin Domain I Golgin_A5 PF09787.7 001097483.2_49823001_2 - 1.1 8.6 52.8 0.58 9.4 19.0 2.7 1 1 2 3 3 3 0 Golgin subfamily A member 5 DUF1794 PF08768.9 001097483.2_49823001_2 - 1.2 8.9 3.4 20 5.0 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1794) ATG16 PF08614.9 001097483.2_49823001_2 - 1.6 8.7 59.9 2.5 8.1 21.1 3.2 1 1 1 2 2 1 0 Autophagy protein 16 (ATG16) ADIP PF11559.6 001097483.2_49823001_2 - 2 8.3 48.4 2.5 8.0 6.5 4.1 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding DUF3584 PF12128.6 001097483.2_49823001_2 - 2.9 5.1 56.2 2.3 5.5 25.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Reo_sigmaC PF04582.10 001097483.2_49823001_2 - 4.4 6.5 8.3 1.5 8.0 0.9 2.2 2 0 0 2 2 2 0 Reovirus sigma C capsid protein MAD PF05557.11 001097483.2_49823001_2 - 4.9 5.2 57.7 3.3 5.8 27.1 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein Fmp27_WPPW PF10359.7 001097483.2_49823001_2 - 5 5.7 36.1 0.65 8.7 9.5 2.6 1 1 2 3 3 3 0 RNA pol II promoter Fmp27 protein domain Lebercilin PF15619.4 001097483.2_49823001_2 - 5.1 6.6 60.9 2.6 7.5 22.7 3.2 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DASH_Hsk3 PF08227.9 001097483.2_49823001_2 - 5.3 7.4 5.7 9.1 6.6 0.0 3.3 3 1 0 3 3 3 0 DASH complex subunit Hsk3 like Fib_alpha PF08702.8 001097483.2_49823001_2 - 5.5 7.0 29.9 0.17 11.9 6.7 3.3 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family Snapin_Pallidin PF14712.4 001097483.2_49823001_2 - 5.6 7.4 35.1 0.4 11.0 4.0 5.4 2 1 4 6 6 6 0 Snapin/Pallidin HrpB7 PF09486.8 001097483.2_49823001_2 - 6.5 7.0 50.6 0.16 12.2 12.9 4.3 1 1 5 6 6 6 0 Bacterial type III secretion protein (HrpB7) EzrA PF06160.10 001097483.2_49823001_2 - 6.7 4.6 54.2 0.35 8.9 8.5 3.0 1 1 2 3 3 3 0 Septation ring formation regulator, EzrA Exonuc_VII_L PF02601.13 001097483.2_49823001_2 - 7.2 5.9 34.4 1.6e+04 -9.8 34.4 2.3 1 1 0 1 1 0 0 Exonuclease VII, large subunit GAS PF13851.4 001097483.2_49823001_2 - 7.3 5.8 58.7 2 7.6 16.0 2.9 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding APG6 PF04111.10 001097483.2_49823001_2 - 8.1 5.6 61.7 7.5 5.7 27.1 3.1 1 1 2 3 3 3 0 Autophagy protein Apg6 FH2 PF02181.21 001097483.2_49823001_2 - 8.7 5.2 35.5 0.8 8.6 9.0 3.2 1 1 2 3 3 3 0 Formin Homology 2 Domain DUF4472 PF14739.4 001097483.2_49823001_2 - 9.8 6.8 50.4 0.92 10.1 8.9 4.5 1 1 5 6 6 5 0 Domain of unknown function (DUF4472) SNF2_N PF00176.21 001082376.1_37927001_3 - 9.9e-80 267.7 0.3 1.5e-79 267.2 0.3 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.9 001082376.1_37927001_3 - 4.8e-21 74.4 0.0 9.2e-21 73.5 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.29 001082376.1_37927001_3 - 5.4e-13 49.2 0.0 1.6e-12 47.6 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.4 001082376.1_37927001_3 - 1.6e-06 27.8 15.9 3e-06 26.8 15.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001082376.1_37927001_3 - 4.3e-06 26.3 19.3 9.6e-06 25.2 19.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001082376.1_37927001_3 - 1.5e-05 24.7 19.9 3.1e-05 23.6 19.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001082376.1_37927001_3 - 2.2e-05 24.3 16.0 5.3e-05 23.0 16.0 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 001082376.1_37927001_3 - 6.1e-05 23.1 18.1 0.00016 21.8 18.1 1.8 1 0 0 1 1 1 1 Ring finger domain ResIII PF04851.13 001082376.1_37927001_3 - 0.0004 20.3 0.0 1.3 8.9 0.0 2.9 2 1 0 2 2 2 2 Type III restriction enzyme, res subunit zf-RING_5 PF14634.4 001082376.1_37927001_3 - 0.0013 18.5 17.6 0.0013 18.5 17.6 1.8 2 0 0 2 2 1 1 zinc-RING finger domain Prok-RING_4 PF14447.4 001082376.1_37927001_3 - 0.0029 17.3 16.7 0.0062 16.2 16.7 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.5 001082376.1_37927001_3 - 0.0066 16.3 6.6 0.017 15.1 6.6 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.4 001082376.1_37927001_3 - 0.013 15.5 18.3 0.013 15.5 18.3 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.4 001082376.1_37927001_3 - 0.058 13.1 7.5 0.14 12.0 7.5 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Abhydrolase_1 PF00561.18 024527.4_26225001_1 - 1.8e-23 83.3 0.1 1e-17 64.5 0.1 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 024527.4_26225001_1 - 4.9e-16 58.6 1.4 8.8e-15 54.5 1.4 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.5 024527.4_26225001_1 - 1.9e-14 54.7 0.1 1.9e-14 54.7 0.1 2.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.14 024527.4_26225001_1 - 0.0032 17.2 0.1 1.8 8.2 0.0 2.8 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase DUF2920 PF11144.6 024527.4_26225001_1 - 0.0068 15.5 0.0 1.6 7.7 0.0 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF2920) FSH1 PF03959.11 024527.4_26225001_1 - 0.037 13.5 0.0 0.062 12.8 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Peptidase_S9 PF00326.19 024527.4_26225001_1 - 0.038 13.3 0.0 0.2 11.0 0.0 2.0 2 0 0 2 2 2 0 Prolyl oligopeptidase family Abhydrolase_4 PF08386.8 024527.4_26225001_1 - 0.054 13.5 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 TAP-like protein Peptidase_S15 PF02129.16 024527.4_26225001_1 - 0.058 12.9 0.0 3.3 7.1 0.0 2.2 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_8 PF06259.10 024527.4_26225001_1 - 0.12 11.9 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase DLH PF01738.16 024527.4_26225001_1 - 0.17 11.3 0.0 17 4.7 0.0 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family Metallophos PF00149.26 001101722.1_37922001_2 - 2.4e-39 135.8 0.1 3e-39 135.5 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.3 001101722.1_37922001_2 - 1.4e-20 73.3 0.5 3.1e-20 72.2 0.5 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain IL8 PF00048.18 001032821.1_29621001_1 - 5.6e-23 80.7 2.9 6.9e-23 80.4 2.9 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like DUF4725 PF15854.3 001032821.1_29621001_1 - 0.0078 16.3 0.2 0.0096 16.0 0.1 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4725) Glyco_transf_29 PF00777.16 001037299.1_39723001_1 - 2e-69 233.9 0.0 2.4e-69 233.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) SNF2_N PF00176.21 001114728.1_37927001_3 - 9.4e-80 267.8 0.3 1.4e-79 267.2 0.3 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.9 001114728.1_37927001_3 - 4.6e-21 74.4 0.0 9e-21 73.5 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.29 001114728.1_37927001_3 - 3e-13 50.0 0.0 8.5e-13 48.5 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.4 001114728.1_37927001_3 - 1.6e-06 27.7 15.9 3e-06 26.9 15.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001114728.1_37927001_3 - 4.4e-06 26.3 19.3 9.4e-06 25.2 19.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001114728.1_37927001_3 - 1.5e-05 24.7 19.9 3.1e-05 23.6 19.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001114728.1_37927001_3 - 2.2e-05 24.2 16.0 5.2e-05 23.0 16.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.4 001114728.1_37927001_3 - 6.3e-05 23.0 18.1 0.00015 21.8 18.1 1.7 1 0 0 1 1 1 1 Ring finger domain ResIII PF04851.13 001114728.1_37927001_3 - 0.00037 20.4 0.0 1.3 8.9 0.0 2.9 2 1 0 2 2 2 2 Type III restriction enzyme, res subunit zf-RING_5 PF14634.4 001114728.1_37927001_3 - 0.0013 18.6 17.6 0.0013 18.6 17.6 1.8 2 0 0 2 2 1 1 zinc-RING finger domain Prok-RING_4 PF14447.4 001114728.1_37927001_3 - 0.0029 17.3 16.7 0.0061 16.3 16.7 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.4 001114728.1_37927001_3 - 0.0064 16.5 18.3 0.013 15.5 18.3 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.5 001114728.1_37927001_3 - 0.0065 16.4 6.6 0.016 15.1 6.6 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.4 001114728.1_37927001_3 - 0.055 13.2 7.5 0.13 12.0 7.5 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Ig_3 PF13927.4 001047103.1_45723001_1 - 4.4e-30 104.0 3.2 2.1e-09 37.7 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 001047103.1_45723001_1 - 8.8e-27 93.1 0.9 4.6e-09 36.4 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 001047103.1_45723001_1 - 4.9e-25 87.3 0.0 3.2e-08 33.4 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.23 001047103.1_45723001_1 - 5.6e-24 84.0 3.3 6.5e-09 35.7 0.4 3.4 3 1 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.10 001047103.1_45723001_1 - 5e-18 64.8 2.2 2.2e-17 62.8 0.1 2.6 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain V-set PF07686.15 001047103.1_45723001_1 - 3e-13 49.8 6.7 6.4e-08 32.6 0.0 4.1 3 1 1 4 4 4 3 Immunoglobulin V-set domain C1-set PF07654.13 001047103.1_45723001_1 - 3.4e-09 36.9 0.9 8.4e-08 32.5 0.0 2.8 3 0 0 3 3 3 1 Immunoglobulin C1-set domain Izumo-Ig PF16706.3 001047103.1_45723001_1 - 2.5e-06 27.3 0.0 0.1 12.6 0.0 2.9 3 0 0 3 3 2 2 Izumo-like Immunoglobulin domain Ig_4 PF16680.3 001047103.1_45723001_1 - 0.0015 18.7 0.7 1.5 9.1 0.0 3.6 3 1 1 4 4 4 1 T-cell surface glycoprotein CD3 delta chain Syndecan PF01034.18 001047103.1_45723001_1 - 0.029 14.1 0.0 0.11 12.3 0.0 2.0 2 0 0 2 2 2 0 Syndecan domain DUF4307 PF14155.4 001047103.1_45723001_1 - 0.059 13.1 0.2 0.66 9.7 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4307) Mlf1IP PF10248.7 001047103.1_45723001_1 - 0.071 12.9 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 Myelodysplasia-myeloid leukemia factor 1-interacting protein EVC2_like PF12297.6 001047103.1_45723001_1 - 0.21 10.1 0.0 0.33 9.5 0.0 1.2 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein S_100 PF01023.17 001082163.1_37921001_1 - 7.5e-17 60.6 0.9 1e-16 60.2 0.9 1.2 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 001082163.1_37921001_1 - 1.4e-06 28.5 0.2 1.7e-06 28.3 0.2 1.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 001082163.1_37921001_1 - 1.9e-05 23.8 0.7 0.005 16.2 0.1 2.4 2 0 0 2 2 2 2 EF hand EFhand_Ca_insen PF08726.8 001082163.1_37921001_1 - 0.00056 19.8 0.2 0.00099 19.0 0.1 1.7 2 0 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_8 PF13833.4 001082163.1_37921001_1 - 0.00098 18.7 0.5 0.0043 16.6 0.5 2.0 1 1 0 1 1 1 1 EF-hand domain pair CpcD PF01383.19 020178.4_26227001_1 - 0.081 13.1 0.2 0.17 12.1 0.2 1.5 1 0 0 1 1 1 0 CpcD/allophycocyanin linker domain Ribosomal_60s PF00428.17 020178.4_26227001_1 - 0.24 11.9 3.2 0.42 11.1 3.2 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein Carb_anhydrase PF00194.19 020178.4_26227001_3 - 1.3e-65 221.3 0.1 2e-65 220.7 0.1 1.3 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Asp-B-Hydro_N PF05279.9 001082743.1_37929001_3 - 0.00098 19.1 49.9 0.00098 19.1 49.9 4.0 2 2 1 3 3 3 1 Aspartyl beta-hydroxylase N-terminal region PX PF00787.22 001034464.2_06525001_2 - 6e-20 71.2 1.2 1.3e-19 70.1 0.2 2.1 2 0 0 2 2 2 1 PX domain Vps5 PF09325.8 001034464.2_06525001_2 - 4.2e-18 65.6 11.7 7.2e-16 58.3 11.7 2.3 1 1 0 1 1 1 1 Vps5 C terminal like BAR PF03114.16 001034464.2_06525001_2 - 0.00085 18.9 13.4 0.0073 15.8 10.2 2.2 2 0 0 2 2 2 2 BAR domain PH PF00169.27 001107933.1_45728001_1 - 1.1e-06 28.9 0.2 1.9e-06 28.2 0.2 1.3 1 0 0 1 1 1 1 PH domain RabGAP-TBC PF00566.16 001107933.1_45728001_2 - 1.2e-51 175.3 0.1 2e-51 174.6 0.1 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain AIF-MLS PF14962.4 001109556.1_45723001_3 - 8.1e-88 293.3 10.8 8.1e-88 293.3 10.8 2.0 1 1 1 2 2 2 1 Mitochondria Localisation Sequence NDUF_B7 PF05676.11 001108442.1_45722001_3 - 3.7e-29 100.1 7.5 5.1e-29 99.7 7.5 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.8 001108442.1_45722001_3 - 0.028 14.3 7.3 0.042 13.7 7.3 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like Tyrosinase PF00264.18 001106664.1_45726001_3 - 1.6e-34 120.0 0.0 2.4e-34 119.4 0.0 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase Rpp20 PF12328.6 001105918.1_45722001_3 - 2e-19 69.7 0.0 1.1e-17 64.1 0.0 2.1 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.19 001105918.1_45722001_3 - 1e-08 34.7 0.0 1.6e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Alba Glyco_transf_29 PF00777.16 001105859.1_45725001_3 - 1.2e-76 257.5 0.0 1.7e-76 257.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) CCSAP PF15748.3 001107441.1_45723001_2 - 3.5e-95 318.8 15.1 4.2e-95 318.6 15.1 1.1 1 0 0 1 1 1 1 Centriole, cilia and spindle-associated DSPn PF14671.4 001108404.1_45727001_1 - 8.6e-55 184.9 2.6 9.7e-54 181.5 2.0 2.2 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.18 001108404.1_45727001_1 - 9.6e-14 51.2 0.0 2.1e-13 50.1 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 001108404.1_45727001_1 - 5.5e-06 26.5 0.0 9.1e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.25 001108404.1_45727001_1 - 0.00027 20.5 0.0 0.00042 19.8 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.4 001108404.1_45727001_1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family Peptidase_M10 PF00413.22 001082203.1_37925001_3 - 9.8e-62 207.3 0.0 3e-61 205.7 0.0 1.7 1 1 0 1 1 1 1 Matrixin fn2 PF00040.17 001082203.1_37925001_3 - 4.6e-56 186.7 33.1 1e-19 70.3 4.7 3.8 3 0 0 3 3 3 3 Fibronectin type II domain Hemopexin PF00045.17 001082203.1_37925001_3 - 2.1e-27 94.7 5.1 4.5e-09 36.0 0.1 4.6 4 0 0 4 4 4 4 Hemopexin PT PF04886.10 001082203.1_37925001_3 - 7.3e-09 34.9 21.2 7.3e-09 34.9 21.2 2.6 2 0 0 2 2 2 1 PT repeat PG_binding_1 PF01471.16 001082203.1_37925001_3 - 9.6e-06 25.6 0.0 2.2e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Peptidase_M66 PF10462.7 001082203.1_37925001_3 - 0.031 13.1 0.3 0.047 12.5 0.3 1.2 1 0 0 1 1 1 0 Peptidase M66 Astacin PF01400.22 001082203.1_37925001_3 - 0.033 13.7 0.1 3.2 7.2 0.0 2.2 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Reprolysin_4 PF13583.4 001082203.1_37925001_3 - 0.047 13.2 0.0 0.084 12.4 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.4 001082203.1_37925001_3 - 0.071 13.5 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.3 001082203.1_37925001_3 - 0.11 11.5 0.3 0.18 10.9 0.3 1.2 1 0 0 1 1 1 0 Met-zincin NADH_B2 PF14813.4 001071798.1_39721001_1 - 2.3e-37 126.5 2.8 2.8e-37 126.2 2.8 1.1 1 0 0 1 1 1 1 NADH dehydrogenase 1 beta subcomplex subunit 2 Kv2channel PF03521.12 001082087.1_37926001_1 - 1.2e-54 185.5 12.7 1.7e-46 158.8 9.9 2.3 2 0 0 2 2 2 2 Kv2 voltage-gated K+ channel Ion_trans PF00520.29 001082087.1_37926001_1 - 1.4e-48 165.1 7.7 1.8e-48 164.8 7.7 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 001082087.1_37926001_1 - 2.4e-32 111.0 0.0 5.8e-32 109.8 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 001082087.1_37926001_1 - 5.6e-12 45.3 2.8 5.6e-12 45.3 2.8 2.2 2 0 0 2 2 2 1 Ion channel DUF4790 PF16037.3 001082087.1_37926001_1 - 0.13 12.6 1.9 0.41 11.0 1.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4790) Perilipin PF03036.14 001013706.2_26225001_3 - 5e-124 414.2 5.1 2.6e-123 411.8 5.1 1.8 1 1 0 1 1 1 1 Perilipin family Fzo_mitofusin PF04799.11 001013706.2_26225001_3 - 0.065 12.6 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 fzo-like conserved region DASH_Dad2 PF08654.8 001013706.2_26225001_3 - 0.25 11.6 0.9 0.8 10.0 0.2 2.1 2 0 0 2 2 2 0 DASH complex subunit Dad2 FUSC PF04632.10 001013706.2_26225001_3 - 1.5 7.2 9.3 8.6 4.6 9.3 1.9 1 1 0 1 1 1 0 Fusaric acid resistance protein family UCH PF00443.27 001108144.1_45729001_1 - 2.1e-46 158.4 0.1 3.1e-46 157.8 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA_4 PF14555.4 001108144.1_45729001_1 - 0.017 14.8 0.0 0.054 13.2 0.0 1.9 1 0 0 1 1 1 0 UBA-like domain UIM PF02809.18 001108144.1_45729001_1 - 0.11 12.3 0.4 0.45 10.4 0.4 2.2 1 0 0 1 1 1 0 Ubiquitin interaction motif MerR-DNA-bind PF09278.9 001108144.1_45729001_1 - 0.39 11.1 1.6 36 4.8 0.0 2.7 2 0 0 2 2 2 0 MerR, DNA binding TPR_3 PF07720.10 001108144.1_45729001_1 - 0.91 9.4 3.3 0.83 9.6 0.9 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat RITA PF17066.3 001044226.1_45724001_1 - 9.5e-111 369.5 24.2 1.7e-110 368.7 24.2 1.3 1 0 0 1 1 1 1 RBPJ-interacting and tubulin associated protein DEAD PF00270.27 001005381.2_45726001_2 - 4.6e-29 101.3 0.0 9.1e-29 100.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001005381.2_45726001_2 - 2.5e-26 92.1 0.0 5.6e-26 91.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain CI-B14_5a PF07347.10 001079926.1_39721001_1 - 2.1e-36 123.6 0.6 2.4e-36 123.4 0.6 1.0 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) Homeobox PF00046.27 001081478.1_39722001_1 - 1.3e-21 76.0 6.1 1.9e-21 75.5 6.1 1.2 1 0 0 1 1 1 1 Homeobox domain Ion_trans_2 PF07885.14 001082180.1_37923001_3 - 9.8e-33 111.9 17.7 2.3e-17 62.6 2.1 3.0 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.29 001082180.1_37923001_3 - 5.2e-05 22.5 7.7 0.0048 16.0 0.1 2.2 2 0 0 2 2 2 2 Ion transport protein RCC1 PF00415.16 001079920.1_39729001_1 - 4.5e-39 132.7 14.2 4.2e-10 40.0 0.1 6.9 6 1 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat MORN PF02493.18 001079920.1_39729001_1 - 5.4e-30 101.4 30.3 6.9e-06 25.5 0.5 9.1 8 1 0 8 8 8 8 MORN repeat RCC1_2 PF13540.4 001079920.1_39729001_1 - 3.6e-28 96.6 20.6 4e-09 35.9 0.2 7.7 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat VPS9 PF02204.16 001079920.1_39729001_1 - 3.9e-24 84.7 0.1 3.8e-23 81.5 0.2 2.4 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain RhoGEF PF00621.18 001079920.1_39729001_1 - 1.1e-07 32.2 2.9 2.3e-07 31.1 2.9 1.6 1 0 0 1 1 1 1 RhoGEF domain DUF3915 PF13054.4 001106553.1_45724001_1 - 2.5 8.0 6.3 3.7 7.4 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Homeobox PF00046.27 001106553.1_45724001_2 - 6.4e-25 86.6 5.9 1.1e-24 85.9 5.9 1.4 1 0 0 1 1 1 1 Homeobox domain OAR PF03826.15 001106553.1_45724001_2 - 9.7e-10 37.8 3.3 1.7e-09 37.0 3.3 1.4 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.9 001106553.1_45724001_2 - 0.0012 18.6 0.2 0.0022 17.7 0.2 1.4 1 0 0 1 1 1 1 Homeobox KN domain DUF3915 PF13054.4 001106553.1_45724001_2 - 0.75 9.7 6.1 1.2 9.0 4.8 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3915) DOT1 PF08123.11 001108733.1_45729001_3 - 8.4e-83 276.8 0.0 1.6e-82 275.9 0.0 1.5 1 0 0 1 1 1 1 Histone methylation protein DOT1 HALZ PF02183.16 001108733.1_45729001_3 - 0.98 9.5 9.7 0.23 11.6 0.8 2.8 1 1 1 2 2 2 0 Homeobox associated leucine zipper AT_hook PF02178.17 001108733.1_45729001_3 - 5.9 7.0 9.2 0.72 9.8 3.1 3.0 2 0 0 2 2 2 0 AT hook motif SIR2 PF02146.15 001107073.1_45724001_3 - 2.5e-26 92.5 0.9 3.5e-20 72.5 0.3 2.2 1 1 1 2 2 2 2 Sir2 family TPP_enzyme_M PF00205.20 001107073.1_45724001_3 - 0.029 14.0 0.2 2.6 7.7 0.0 2.8 3 0 0 3 3 3 0 Thiamine pyrophosphate enzyme, central domain TOM_sub5 PF15178.4 001107073.1_45724001_3 - 0.15 11.9 0.0 0.34 10.8 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial import receptor subunit TOM5 homolog MNR PF15718.3 001107073.1_45724001_3 - 0.93 7.4 7.3 1.3 7.0 7.3 1.1 1 0 0 1 1 1 0 Protein moonraker CC2-LZ PF16516.3 001032897.1_29625001_1 - 8.5e-32 109.4 16.1 8.5e-32 109.4 16.1 5.6 2 2 2 4 4 4 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator NEMO PF11577.6 001032897.1_29625001_1 - 5.1e-28 96.8 16.4 5.1e-28 96.8 16.4 5.7 5 2 0 5 5 5 1 NF-kappa-B essential modulator NEMO IncA PF04156.12 001032897.1_29625001_1 - 0.0035 17.0 11.3 0.0035 17.0 11.3 4.4 2 1 2 4 4 4 1 IncA protein THOC7 PF05615.11 001032897.1_29625001_1 - 0.0094 16.1 2.9 0.0094 16.1 2.9 4.9 3 1 1 4 4 4 1 Tho complex subunit 7 TGFb_propeptide PF00688.16 001079919.1_39723001_1 - 1.9e-31 109.6 0.0 2.6e-31 109.1 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001079919.1_39723001_1 - 2.3e-28 99.0 1.1 6e-28 97.7 1.1 1.8 1 0 0 1 1 1 1 Transforming growth factor beta like domain Rap_GAP PF02145.13 001107019.1_45728001_1 - 2.5e-61 206.4 0.0 3.6e-61 205.9 0.0 1.2 1 0 0 1 1 1 1 Rap/ran-GAP Sox_N PF12444.6 001099933.1_49824001_3 - 8.5e-29 100.4 0.0 4e-28 98.2 0.0 2.2 1 0 0 1 1 1 1 Sox developmental protein N terminal HMG_box PF00505.17 001099933.1_49824001_3 - 6.3e-25 87.3 1.5 1.1e-24 86.5 1.5 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 001099933.1_49824001_3 - 5.4e-10 39.6 0.9 9.8e-10 38.8 0.9 1.4 1 0 0 1 1 1 1 HMG-box domain zf-C2H2_jaz PF12171.6 001106568.1_45727001_2 - 3.6e-07 30.2 12.6 2.9e-06 27.3 0.4 4.3 4 1 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 001106568.1_45727001_2 - 0.00058 20.0 17.5 0.013 15.7 2.1 3.9 3 1 1 4 4 4 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.4 001106568.1_45727001_2 - 0.02 15.6 23.2 0.11 13.3 0.4 4.2 4 0 0 4 4 4 0 C2H2-type zinc finger zf-met PF12874.5 001106568.1_45727001_2 - 0.087 13.1 20.5 0.053 13.8 3.5 4.5 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.24 001106568.1_45727001_2 - 0.16 12.3 21.5 0.56 10.6 0.9 4.1 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-U1 PF06220.10 001106568.1_45727001_2 - 2.6 7.8 12.7 17 5.1 0.1 3.5 3 0 0 3 3 3 0 U1 zinc finger EF-hand_4 PF12763.5 001029921.1_45727001_1 - 5.2e-41 138.7 0.0 9.8e-23 80.0 0.0 4.1 4 0 0 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.30 001029921.1_45727001_1 - 1.4e-14 52.3 0.5 0.0032 16.8 0.1 4.5 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 001029921.1_45727001_1 - 5.8e-09 35.1 1.4 0.42 10.6 0.2 4.8 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.4 001029921.1_45727001_1 - 1.6e-07 31.5 1.2 0.047 14.0 0.1 4.1 2 2 1 3 3 3 2 EF-hand domain pair EzrA PF06160.10 001029921.1_45727001_1 - 4.9e-05 21.6 33.9 0.00013 20.2 33.9 1.5 1 1 0 1 1 1 1 Septation ring formation regulator, EzrA Macoilin PF09726.7 001029921.1_45727001_1 - 5.5e-05 21.8 12.0 8.4e-05 21.2 12.0 1.3 1 0 0 1 1 1 1 Transmembrane protein EF-hand_8 PF13833.4 001029921.1_45727001_1 - 0.0011 18.6 0.8 0.28 10.9 0.2 3.6 4 0 0 4 4 4 1 EF-hand domain pair Reo_sigmaC PF04582.10 001029921.1_45727001_1 - 0.0092 15.3 14.0 0.011 15.0 10.4 2.0 1 1 1 2 2 2 2 Reovirus sigma C capsid protein IFT57 PF10498.7 001029921.1_45727001_1 - 0.012 14.5 25.9 0.023 13.6 25.9 1.5 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 EF-hand_5 PF13202.4 001029921.1_45727001_1 - 0.025 14.0 2.2 0.4 10.2 0.1 2.8 2 0 0 2 2 2 0 EF hand DUF4201 PF13870.4 001029921.1_45727001_1 - 0.052 13.1 33.9 0.034 13.7 18.0 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) EF-hand_9 PF14658.4 001029921.1_45727001_1 - 0.058 13.6 0.0 0.28 11.4 0.0 2.3 1 0 0 1 1 1 0 EF-hand domain Spc7 PF08317.9 001029921.1_45727001_1 - 0.062 12.0 41.4 0.3 9.8 15.5 2.4 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF16 PF01519.14 001029921.1_45727001_1 - 0.069 13.5 25.9 0.39 11.1 9.9 2.6 2 0 0 2 2 2 0 Protein of unknown function DUF16 ATG16 PF08614.9 001029921.1_45727001_1 - 0.11 12.5 50.7 0.17 11.9 30.0 3.1 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) Med30 PF11315.6 001029921.1_45727001_1 - 0.11 12.6 19.6 0.11 12.7 17.7 1.8 1 1 1 2 2 2 0 Mediator complex subunit 30 HMMR_N PF15905.3 001029921.1_45727001_1 - 0.14 11.5 39.3 0.33 10.2 21.6 2.3 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal CALCOCO1 PF07888.9 001029921.1_45727001_1 - 0.21 10.0 35.4 0.36 9.2 35.4 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF4763 PF15960.3 001029921.1_45727001_1 - 0.25 10.5 38.3 0.15 11.2 7.9 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) MPS2 PF17060.3 001029921.1_45727001_1 - 0.29 10.2 17.7 0.46 9.5 17.7 1.3 1 0 0 1 1 1 0 Monopolar spindle protein 2 LMBR1 PF04791.14 001029921.1_45727001_1 - 0.29 9.8 13.0 0.49 9.1 13.0 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Atg14 PF10186.7 001029921.1_45727001_1 - 0.96 8.3 40.6 8.5 5.2 24.8 2.5 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Leu_zip PF15294.4 001029921.1_45727001_1 - 2 7.7 34.0 0.33 10.3 26.3 2.2 1 1 1 2 2 2 0 Leucine zipper IncA PF04156.12 001029921.1_45727001_1 - 2.2 7.9 57.2 0.056 13.1 28.0 2.9 2 1 1 3 3 3 0 IncA protein MAD PF05557.11 001029921.1_45727001_1 - 4.3 5.4 39.6 11 4.0 39.6 1.6 1 1 0 1 1 1 0 Mitotic checkpoint protein DUF745 PF05335.11 001029921.1_45727001_1 - 4.4 6.9 30.4 3.1 7.4 17.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF745) AAA_13 PF13166.4 001029921.1_45727001_1 - 4.6 5.7 26.3 28 3.1 26.0 2.0 1 1 0 1 1 1 0 AAA domain Fez1 PF06818.13 001029921.1_45727001_1 - 5.8 7.2 43.1 0.92 9.8 22.1 2.6 2 1 1 3 3 2 0 Fez1 Prominin PF05478.9 001029921.1_45727001_1 - 6.3 4.5 25.5 0.17 9.7 7.7 1.8 1 1 0 1 1 1 0 Prominin FUSC PF04632.10 001029921.1_45727001_1 - 6.8 5.0 12.4 12 4.2 12.4 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family TMPIT PF07851.11 001029921.1_45727001_1 - 7 5.7 30.4 1.3 8.1 13.3 2.2 1 1 0 2 2 2 0 TMPIT-like protein ERM PF00769.17 001029921.1_45727001_1 - 7.1 6.3 44.4 0.021 14.5 33.0 2.2 2 0 0 2 2 1 0 Ezrin/radixin/moesin family DUF948 PF06103.9 001029921.1_45727001_1 - 8.1 6.6 14.3 15 5.8 0.3 3.3 1 1 3 4 4 4 0 Bacterial protein of unknown function (DUF948) TRPM_tetra PF16519.3 206946.3_26229001_2 - 5.6e-24 83.9 5.4 1.1e-23 82.9 5.4 1.6 1 0 0 1 1 1 1 Tetramerisation domain of TRPM Ion_trans PF00520.29 206946.3_26229001_2 - 5.1e-18 65.1 17.7 7.8e-18 64.5 17.7 1.3 1 0 0 1 1 1 1 Ion transport protein DUF3552 PF12072.6 206946.3_26229001_2 - 0.028 13.7 4.3 0.071 12.4 4.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Reo_sigmaC PF04582.10 206946.3_26229001_2 - 0.08 12.2 0.4 0.15 11.3 0.4 1.3 1 0 0 1 1 1 0 Reovirus sigma C capsid protein RWD PF05773.20 001012004.2_45723001_3 - 1.6e-18 67.0 0.0 3.5e-18 65.8 0.0 1.6 1 0 0 1 1 1 1 RWD domain zf-RING_2 PF13639.4 001012004.2_45723001_3 - 1.7e-06 28.0 10.3 8.4e-06 25.8 10.3 2.1 1 1 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.3 001012004.2_45723001_3 - 6.3e-06 25.7 8.6 6.3e-06 25.7 8.6 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.23 001012004.2_45723001_3 - 0.0098 15.6 8.9 0.074 12.8 9.1 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001012004.2_45723001_3 - 0.02 14.7 13.1 0.062 13.1 13.1 1.9 1 1 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.4 001012004.2_45723001_3 - 0.046 13.6 8.7 0.26 11.2 4.3 2.7 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_2 PF13923.4 001012004.2_45723001_3 - 0.092 12.5 11.5 0.035 13.8 6.4 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001012004.2_45723001_3 - 0.54 10.0 8.8 12 5.8 4.8 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zf_RING PF16744.3 001012004.2_45723001_3 - 0.92 9.5 4.7 1.9 8.5 4.7 1.4 1 0 0 1 1 1 0 KIAA1045 RING finger zf-ANAPC11 PF12861.5 001012004.2_45723001_3 - 1.5 8.8 7.8 1.1 9.2 4.5 2.1 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.5 001012004.2_45723001_3 - 3.7 7.8 12.9 37 4.6 13.3 2.3 1 1 0 1 1 1 0 RING-H2 zinc finger domain SAGA-Tad1 PF12767.5 001037199.3_45724001_1 - 0.007 16.0 0.8 0.0095 15.6 0.8 1.1 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit adh_short PF00106.23 001037199.3_45724001_3 - 9.7e-40 136.0 0.0 1.3e-39 135.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001037199.3_45724001_3 - 2.6e-29 102.3 0.0 5.6e-29 101.2 0.0 1.4 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001037199.3_45724001_3 - 2.7e-19 69.7 0.0 4.3e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.13 001037199.3_45724001_3 - 5.3e-07 28.9 0.1 7.6e-07 28.4 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.19 001037199.3_45724001_3 - 0.0028 17.0 0.1 0.0041 16.5 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.18 001037199.3_45724001_3 - 0.045 13.7 0.0 0.079 12.9 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ETRAMP PF09716.8 001037199.3_45724001_3 - 0.66 9.9 5.2 1.7 8.6 0.0 2.5 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Cation_ATPase_C PF00689.19 001101719.1_37929001_1 - 1.5e-42 145.2 4.2 1.5e-42 145.2 4.2 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.18 001101719.1_37929001_1 - 3.6e-36 124.4 11.4 1.4e-26 93.0 1.0 2.6 3 0 0 3 3 3 2 E1-E2 ATPase ATP_Ca_trans_C PF12424.6 001101719.1_37929001_1 - 4e-26 91.1 0.2 1.1e-25 89.7 0.2 1.8 1 0 0 1 1 1 1 Plasma membrane calcium transporter ATPase C terminal Cation_ATPase PF13246.4 001101719.1_37929001_1 - 1.7e-16 59.9 0.0 3.5e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.24 001101719.1_37929001_1 - 4.8e-14 51.6 0.0 1.2e-13 50.4 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.24 001101719.1_37929001_1 - 2.1e-13 50.9 0.1 6.3e-10 39.6 0.2 2.7 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.10 001101719.1_37929001_1 - 0.00034 20.3 8.9 0.00098 18.8 0.5 2.8 2 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase DUF2201_N PF13203.4 001101719.1_37929001_1 - 0.22 11.0 0.5 0.33 10.4 0.5 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain Furin-like_2 PF15913.3 001107980.1_45724001_3 - 1.5e-46 156.8 20.8 1.5e-46 156.8 20.8 2.1 3 0 0 3 3 3 1 Furin-like repeat, cysteine-rich TSP_1 PF00090.17 001107980.1_45724001_3 - 1.6e-05 24.9 7.9 1.6e-05 24.9 7.9 3.6 3 1 0 3 3 3 1 Thrombospondin type 1 domain ILEI PF15711.3 001109324.1_45724001_1 - 1.9e-25 89.0 0.0 2.8e-25 88.5 0.0 1.2 1 0 0 1 1 1 1 Interleukin-like EMT inducer Na_K-ATPase PF00287.16 013113.2_45725001_2 - 7.8e-98 327.0 0.1 1.1e-97 326.5 0.1 1.1 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain JAKMIP_CC3 PF16034.3 001099433.1_26227001_1 - 6.4e-83 277.5 18.9 6.4e-83 277.5 18.9 6.6 3 2 3 6 6 6 1 JAKMIP CC3 domain SAB PF04382.11 001099433.1_26227001_1 - 6.3 6.8 10.8 3.6 7.6 1.9 3.9 3 0 0 3 3 3 0 SAB domain PUF PF00806.17 001108684.1_45729001_1 - 2.1e-67 219.0 13.1 8.6e-09 34.5 0.1 8.9 9 0 0 9 9 9 8 Pumilio-family RNA binding repeat CPL PF08144.9 001108684.1_45729001_1 - 0.067 13.4 0.8 14 5.9 0.0 3.6 2 1 2 4 4 4 0 CPL (NUC119) domain Skp1 PF01466.17 001034781.2_06522001_1 - 2.5e-30 104.2 1.9 4.3e-30 103.4 1.9 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.13 001034781.2_06522001_1 - 7.9e-30 102.7 0.2 1.7e-29 101.6 0.2 1.6 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain SET PF00856.26 001108883.1_45729001_2 - 6.8e-20 72.0 0.1 2e-19 70.5 0.0 1.8 2 0 0 2 2 2 1 SET domain Pre-SET PF05033.14 001108883.1_45729001_2 - 4.9e-16 59.2 6.0 4.9e-16 59.2 6.0 2.9 3 0 0 3 3 3 1 Pre-SET motif Chromo PF00385.22 001108883.1_45729001_2 - 1.2e-12 47.3 2.0 2.6e-12 46.3 2.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain MF_alpha PF04648.10 001082286.1_37925001_1 - 0.17 12.1 4.5 0.73 10.1 4.5 2.2 1 0 0 1 1 1 0 Yeast mating factor alpha hormone A2M_comp PF07678.12 001082286.1_37925001_2 - 5.7e-57 192.9 2.5 6.9e-56 189.3 2.5 2.2 1 1 0 1 1 1 1 A-macroglobulin complement component A2M_recep PF07677.12 001082286.1_37925001_2 - 7.3e-31 106.7 0.6 1.1e-29 102.9 0.2 2.5 2 0 0 2 2 2 1 A-macroglobulin receptor NTR PF01759.19 001082286.1_37925001_2 - 8.3e-27 93.0 0.0 2.1e-26 91.7 0.0 1.7 1 0 0 1 1 1 1 UNC-6/NTR/C345C module Thiol-ester_cl PF10569.7 001082286.1_37925001_2 - 2.1e-09 36.8 0.0 5.2e-09 35.5 0.0 1.7 1 0 0 1 1 1 1 Alpha-macro-globulin thiol-ester bond-forming region RasGAP_C PF03836.13 001082286.1_37925001_2 - 0.067 13.2 0.1 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 RasGAP C-terminus Sulfatase PF00884.21 001047885.1_45724001_1 - 1.8e-83 280.3 0.0 2.5e-83 279.9 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.4 001047885.1_45724001_1 - 6.2e-39 133.4 0.0 1.2e-38 132.5 0.0 1.5 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.20 001047885.1_45724001_1 - 5.4e-06 26.1 0.0 0.081 12.4 0.0 2.1 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4576 PF15144.4 001106149.1_45722001_2 - 1.6e-40 136.7 0.0 2.3e-40 136.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4576) SNN_transmemb PF09049.8 001106149.1_45722001_2 - 0.091 12.6 1.3 0.15 11.9 1.3 1.3 1 0 0 1 1 1 0 Stannin transmembrane Na_K-ATPase PF00287.16 001082091.1_37923001_1 - 1.9e-96 322.4 0.0 2.4e-96 322.1 0.0 1.1 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain Ank_2 PF12796.5 001082054.1_37924001_3 - 1.9e-36 124.4 11.4 9.8e-14 51.6 0.4 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001082054.1_37924001_3 - 1.3e-26 92.1 5.4 3.9e-11 42.8 0.1 4.5 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.28 001082054.1_37924001_3 - 8.6e-25 85.9 3.0 2.5e-05 24.4 0.0 4.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.4 001082054.1_37924001_3 - 1.1e-24 86.3 2.2 1.5e-10 41.2 0.2 3.8 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 001082054.1_37924001_3 - 1.2e-21 74.3 2.8 0.00068 19.8 0.0 5.2 6 0 0 6 6 6 4 Ankyrin repeat DUF1843 PF08898.8 001082054.1_37924001_3 - 7 7.1 6.3 28 5.2 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1843) Ion_trans PF00520.29 001082384.1_37928001_1 - 5.3e-35 120.7 1.6 7.2e-35 120.2 1.6 1.2 1 0 0 1 1 1 1 Ion transport protein PAS_9 PF13426.5 001082384.1_37928001_1 - 2.7e-13 49.9 0.1 6e-13 48.8 0.1 1.5 1 0 0 1 1 1 1 PAS domain cNMP_binding PF00027.27 001082384.1_37928001_1 - 9.3e-12 44.7 0.0 2.2e-11 43.5 0.0 1.7 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.14 001082384.1_37928001_1 - 3.1e-11 43.0 0.5 1.1e-10 41.2 0.5 2.0 1 0 0 1 1 1 1 Ion channel PAS PF00989.23 001082384.1_37928001_1 - 4.9e-05 23.2 0.0 0.024 14.5 0.0 2.8 1 1 0 1 1 1 1 PAS fold PAS_8 PF13188.5 001082384.1_37928001_1 - 0.016 15.0 0.0 0.049 13.5 0.0 1.8 1 0 0 1 1 1 0 PAS domain PAS_3 PF08447.10 001082384.1_37928001_1 - 0.031 14.4 0.0 2.1 8.6 0.0 2.4 1 1 1 2 2 2 0 PAS fold Tsg PF04668.10 001108811.2_45722001_1 - 5.6e-46 156.4 5.5 5.6e-46 156.4 5.5 2.2 2 1 0 2 2 2 1 Twisted gastrulation (Tsg) protein conserved region FKBP_C PF00254.26 001105922.1_45723001_2 - 3.7e-17 62.3 0.0 5.8e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.15 001105922.1_45723001_2 - 2.3e-07 30.3 6.5 0.014 15.3 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.4 001105922.1_45723001_2 - 1.6e-05 25.0 8.0 0.00075 19.6 1.1 2.8 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.4 001105922.1_45723001_2 - 0.005 17.2 4.1 0.0068 16.8 1.6 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.26 001105922.1_45723001_2 - 0.024 14.3 3.6 0.67 9.7 0.2 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.4 001105922.1_45723001_2 - 0.036 14.1 0.2 8.2 6.8 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 001105922.1_45723001_2 - 0.16 11.9 1.8 2.4 8.2 0.2 2.4 1 1 1 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.5 001105922.1_45723001_2 - 0.24 11.5 2.8 0.54 10.4 2.8 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.4 001105922.1_45723001_2 - 0.32 11.6 3.4 2.3 8.8 0.6 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.4 001105922.1_45723001_2 - 0.34 10.7 1.4 1.7 8.5 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat ETS_PEA3_N PF04621.11 001108299.1_45725001_2 - 2.6e-116 389.2 9.2 4.8e-116 388.3 9.2 1.5 1 0 0 1 1 1 1 PEA3 subfamily ETS-domain transcription factor N terminal domain Ets PF00178.20 001108299.1_45725001_2 - 2.8e-38 130.1 0.1 4.3e-38 129.5 0.1 1.3 1 0 0 1 1 1 1 Ets-domain PKD_channel PF08016.10 001039005.1_45726001_2 - 3e-10 39.2 10.4 6.5e-10 38.1 10.4 1.5 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.29 001039005.1_45726001_2 - 0.016 14.3 18.0 0.031 13.4 18.0 1.4 1 1 0 1 1 1 0 Ion transport protein Nop16 PF09420.8 001047095.1_45723001_3 - 1.5e-22 80.5 5.8 2.6e-15 56.9 1.2 2.1 1 1 1 2 2 2 2 Ribosome biogenesis protein Nop16 Baculo_p33 PF05214.10 001047095.1_45723001_3 - 0.071 12.7 0.4 0.11 12.1 0.2 1.4 2 0 0 2 2 2 0 Baculovirus P33 DUF4572 PF15139.4 001109164.1_45722001_3 - 3.8e-84 281.3 1.1 4.6e-84 281.1 1.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4572) Cofilin_ADF PF00241.18 001033666.1_45724001_2 - 9.2e-29 100.0 0.2 1.4e-28 99.5 0.2 1.2 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Lys PF00062.18 001097647.1_39521001_1 - 7.3e-58 194.1 2.9 8.3e-58 193.9 2.9 1.0 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family SLT PF01464.18 001097647.1_39521001_1 - 0.00038 20.0 0.0 0.00053 19.5 0.0 1.2 1 0 0 1 1 1 1 Transglycosylase SLT domain COG7 PF10191.7 001033889.1_45726001_2 - 0 1111.0 8.5 0 1110.8 8.5 1.0 1 0 0 1 1 1 1 Golgi complex component 7 (COG7) COG5 PF10392.7 001033889.1_45726001_2 - 0.00021 21.3 0.7 0.00021 21.3 0.7 2.4 3 0 0 3 3 3 1 Golgi transport complex subunit 5 APC_N_CC PF16689.3 001033889.1_45726001_2 - 0.066 13.2 0.3 0.15 12.0 0.3 1.5 1 0 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain Ribosomal_L27 PF01016.17 001105831.1_45722001_3 - 8.7e-25 86.4 0.6 1.3e-24 85.9 0.6 1.3 1 0 0 1 1 1 1 Ribosomal L27 protein zf-met PF12874.5 001108916.1_45729001_1 - 6.5e-09 35.8 25.7 0.0017 18.6 0.1 5.1 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 001108916.1_45729001_1 - 7.7e-07 29.1 19.3 0.039 14.1 1.1 4.1 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.4 001108916.1_45729001_1 - 1.4e-05 25.3 39.5 0.037 14.7 3.5 7.4 7 0 0 7 7 7 3 C2H2-type zinc finger zf-C2H2 PF00096.24 001108916.1_45729001_1 - 3.5e-05 23.9 39.8 0.048 14.0 2.0 6.8 6 0 0 6 6 6 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001108916.1_45729001_1 - 0.023 15.0 0.7 0.023 15.0 0.7 5.4 7 0 0 7 7 7 0 Zinc-finger double domain zf-DNA_Pol PF08996.8 001108916.1_45729001_1 - 0.66 9.6 14.6 1.4 8.5 0.3 3.3 3 0 0 3 3 3 0 DNA Polymerase alpha zinc finger zf-C2H2_aberr PF17017.3 001108916.1_45729001_1 - 0.7 9.9 8.5 2.4 8.2 0.3 3.4 3 0 0 3 3 3 0 Aberrant zinc-finger G-alpha PF00503.18 001038623.1_49823001_2 - 4.6e-119 397.6 1.1 5.6e-119 397.3 1.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 001038623.1_49823001_2 - 3.6e-14 52.5 1.4 1e-10 41.2 0.3 2.8 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001038623.1_49823001_2 - 0.0023 17.2 2.8 0.089 12.0 0.1 2.6 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.11 001038623.1_49823001_2 - 0.013 15.6 0.1 4 7.6 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.21 001038623.1_49823001_2 - 0.075 13.0 0.0 1.9 8.4 0.0 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase DUF3142 PF11340.6 001038623.1_49823001_2 - 0.13 11.9 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3142) AAA_29 PF13555.4 001038623.1_49823001_2 - 0.18 11.4 0.0 0.42 10.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Lipase PF00151.17 001105899.1_45725001_3 - 3.4e-82 276.3 0.0 4.5e-82 275.9 0.0 1.1 1 0 0 1 1 1 1 Lipase Kelch_1 PF01344.23 001105867.1_45725001_1 - 1.1e-36 124.0 4.7 2.2e-11 43.0 0.0 6.7 6 1 0 6 6 6 5 Kelch motif BACK PF07707.13 001105867.1_45725001_1 - 7.6e-34 115.8 1.1 1.9e-33 114.5 1.1 1.7 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.29 001105867.1_45725001_1 - 1.3e-27 96.1 4.3 3.9e-27 94.5 2.5 2.2 1 1 1 2 2 2 1 BTB/POZ domain Kelch_6 PF13964.4 001105867.1_45725001_1 - 1.8e-27 94.5 0.6 0.00014 21.9 0.0 5.9 3 2 3 6 6 6 5 Kelch motif Kelch_2 PF07646.13 001105867.1_45725001_1 - 5.4e-27 92.6 2.0 3.9e-06 26.5 0.1 5.5 5 0 0 5 5 5 5 Kelch motif Kelch_5 PF13854.4 001105867.1_45725001_1 - 3.5e-12 45.9 1.7 0.00013 21.7 0.1 5.3 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.4 001105867.1_45725001_1 - 1.9e-11 43.8 2.7 0.062 13.5 0.0 5.4 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.4 001105867.1_45725001_1 - 6.1e-11 42.0 0.0 0.28 11.1 0.0 5.9 6 0 0 6 6 6 3 Galactose oxidase, central domain DUF3342 PF11822.6 001105867.1_45725001_1 - 8.3e-05 22.6 4.1 0.0004 20.4 0.5 2.8 2 1 1 3 3 3 1 Domain of unknown function (DUF3342) ABC2_membrane PF01061.22 001032919.1_29625001_3 - 7.9e-40 136.4 25.4 7.9e-40 136.4 25.4 1.4 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.25 001032919.1_29625001_3 - 4.7e-23 82.1 0.0 9.7e-21 74.6 0.0 2.2 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.4 001032919.1_29625001_3 - 2.4e-05 24.2 1.8 0.15 11.7 0.1 2.3 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.17 001032919.1_29625001_3 - 3.4e-05 23.3 0.5 0.2 11.0 0.1 2.8 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain ABC2_membrane_3 PF12698.5 001032919.1_29625001_3 - 6.8e-05 22.0 20.2 6.8e-05 22.0 20.2 2.0 1 1 1 2 2 2 1 ABC-2 family transporter protein AAA_23 PF13476.4 001032919.1_29625001_3 - 0.0034 17.8 0.3 0.0034 17.8 0.3 1.6 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.4 001032919.1_29625001_3 - 0.026 14.6 0.1 7.8 6.7 0.0 2.8 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF258 PF03193.14 001032919.1_29625001_3 - 0.037 13.8 0.1 0.11 12.2 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_29 PF13555.4 001032919.1_29625001_3 - 0.075 12.6 0.1 0.18 11.4 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF1774 PF08611.8 001032919.1_29625001_3 - 7.2 6.9 10.3 18 5.6 10.3 1.6 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF1774) An_peroxidase PF03098.13 001105829.1_45726001_1 - 2.8e-06 26.0 0.0 3.7e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase An_peroxidase PF03098.13 001105829.1_45726001_3 - 2e-162 541.3 0.0 2.7e-162 540.9 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase DAG1 PF05454.9 001101700.1_37929001_2 - 3.2e-155 515.6 8.1 4.9e-155 515.0 8.1 1.3 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) TMEM154 PF15102.4 001101700.1_37929001_2 - 0.0074 16.1 0.0 0.0074 16.1 0.0 1.7 2 0 0 2 2 2 1 TMEM154 protein family ATP1G1_PLM_MAT8 PF02038.14 001101700.1_37929001_2 - 0.23 10.7 0.9 0.7 9.2 0.9 1.8 1 0 0 1 1 1 0 ATP1G1/PLM/MAT8 family Ndufs5 PF10200.7 001071789.1_39721001_1 - 3.5e-58 193.7 0.5 4e-58 193.5 0.5 1.0 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa Cmc1 PF08583.8 001071789.1_39721001_1 - 0.00028 20.7 2.2 0.00036 20.3 2.2 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like NDUFB10 PF10249.7 001071824.1_39722001_1 - 8.7e-48 161.8 17.3 1e-47 161.6 17.3 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 Homeobox PF00046.27 001081570.1_39722001_1 - 1.7e-23 82.1 1.3 1.7e-23 82.1 1.3 1.6 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.9 001081570.1_39722001_1 - 0.0019 17.9 0.1 0.0058 16.4 0.1 1.8 1 0 0 1 1 1 1 Homeobox KN domain Calreticulin PF00262.16 001082235.1_37924001_1 - 2.6e-80 269.9 14.1 2.3e-61 207.6 4.1 2.9 2 1 1 3 3 3 2 Calreticulin family DDHD PF02862.15 001082235.1_37924001_1 - 0.12 12.4 3.0 0.17 11.8 3.0 1.2 1 0 0 1 1 1 0 DDHD domain Astro_capsid_p PF12226.6 001082235.1_37924001_1 - 1.1 8.3 18.9 1.9 7.5 18.9 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Nop14 PF04147.10 001082235.1_37924001_1 - 1.5 6.8 28.9 2.5 6.1 28.9 1.3 1 0 0 1 1 1 0 Nop14-like family Nucleo_P87 PF07267.9 001082235.1_37924001_1 - 3 6.5 14.2 4.7 5.8 14.2 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 SAPS PF04499.13 001082235.1_37924001_1 - 4 6.0 11.7 5.7 5.5 11.7 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Presenilin PF01080.15 001082235.1_37924001_1 - 5 5.6 10.9 7.4 5.1 10.9 1.1 1 0 0 1 1 1 0 Presenilin Afi1 PF07792.10 001082235.1_37924001_1 - 6.2 7.2 17.7 18 5.7 17.7 1.7 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking VID27 PF08553.8 001082235.1_37924001_1 - 9.4 4.5 23.3 13 4.1 23.3 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein Rib_hydrolayse PF02267.15 001082683.1_37926001_2 - 1.8e-96 322.1 3.7 2.3e-96 321.8 3.7 1.1 1 0 0 1 1 1 1 ADP-ribosyl cyclase 14-3-3 PF00244.18 001082168.1_37922001_1 - 2.5e-109 363.8 4.9 2.8e-109 363.7 4.9 1.0 1 0 0 1 1 1 1 14-3-3 protein FliM PF02154.13 001082168.1_37922001_1 - 0.12 12.1 0.1 0.19 11.4 0.1 1.3 1 0 0 1 1 1 0 Flagellar motor switch protein FliM DUF3915 PF13054.4 001108321.1_45724001_1 - 0.12 12.2 9.2 0.2 11.5 9.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) FAM27 PF15832.3 001108321.1_45724001_1 - 0.13 12.7 10.5 0.28 11.6 10.5 1.5 1 0 0 1 1 1 0 FAM27 D and E protein family DUF3915 PF13054.4 001108321.1_45724001_2 - 0.28 11.0 11.8 0.52 10.2 11.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.13 001108321.1_45724001_2 - 0.75 7.9 19.7 1 7.4 19.7 1.1 1 0 0 1 1 1 0 Atrophin-1 family zf-3CxxC PF13695.4 001108321.1_45724001_3 - 2.7e-27 95.0 1.1 4.4e-27 94.3 1.1 1.3 1 0 0 1 1 1 1 Zinc-binding domain DUF3915 PF13054.4 001108321.1_45724001_3 - 0.0015 18.3 8.7 0.0027 17.6 8.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3915) zf-3CxxC_2 PF17180.2 001108321.1_45724001_3 - 0.043 14.4 5.0 0.045 14.3 0.4 3.0 3 0 0 3 3 3 0 Zinc-binding domain FAM27 PF15832.3 001108321.1_45724001_3 - 0.4 11.1 9.8 0.71 10.3 9.8 1.4 1 0 0 1 1 1 0 FAM27 D and E protein family Trypan_PARP PF05887.9 001108321.1_45724001_3 - 7.9 6.4 5.6 1.9 8.4 1.1 1.9 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Tub PF01167.16 001109137.1_45729001_1 - 1.7e-32 112.7 0.0 6.2e-25 88.0 0.1 3.2 3 0 0 3 3 3 2 Tub family ANAPC4_WD40 PF12894.5 001109137.1_45729001_1 - 2.3e-08 34.1 1.1 0.00051 20.2 0.0 3.9 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain SOCS_box PF07525.14 001109137.1_45729001_1 - 0.00031 20.9 0.6 0.00031 20.9 0.6 2.6 2 0 0 2 2 2 1 SOCS box DUF3527 PF12043.6 001109137.1_45729001_1 - 0.056 12.9 0.1 0.056 12.9 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3527) BTB PF00651.29 001106657.1_45729001_1 - 1.1e-28 99.5 1.1 2.2e-28 98.6 1.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 001106657.1_45729001_1 - 7.4e-07 29.2 2.8 7.4e-07 29.2 2.8 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.24 001106657.1_45729001_1 - 0.014 15.7 2.4 0.014 15.7 2.4 3.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF3342 PF11822.6 001106657.1_45729001_1 - 0.029 14.4 0.2 0.052 13.6 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) zf-C2H2_4 PF13894.4 001106657.1_45729001_1 - 0.047 14.4 20.0 0.27 12.0 4.5 3.8 3 0 0 3 3 3 0 C2H2-type zinc finger Choline_kinase PF01633.18 001039481.1_26222001_2 - 8.9e-17 61.3 0.0 1.3e-16 60.8 0.0 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase RskA PF10099.7 001039481.1_26222001_2 - 0.00014 22.1 1.6 0.00018 21.7 1.6 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA DUF2771 PF10969.6 001039481.1_26222001_2 - 0.98 9.3 4.3 0.85 9.5 2.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2771) Gal-bind_lectin PF00337.20 001082338.1_37922001_1 - 8.2e-38 128.8 0.0 1e-37 128.6 0.0 1.1 1 0 0 1 1 1 1 Galactoside-binding lectin SH3_1 PF00018.26 001107606.1_45727001_1 - 6.3e-43 144.0 17.9 1.3e-11 43.8 0.2 5.5 5 0 0 5 5 5 5 SH3 domain SH3_9 PF14604.4 001107606.1_45727001_1 - 2.3e-37 126.4 13.6 4.4e-11 42.3 0.1 5.4 5 0 0 5 5 5 5 Variant SH3 domain SH3_2 PF07653.15 001107606.1_45727001_1 - 1.8e-36 123.5 9.0 8.8e-11 41.2 0.1 5.4 5 0 0 5 5 5 5 Variant SH3 domain PX PF00787.22 001107606.1_45727001_1 - 3.7e-17 62.2 0.5 1.5e-16 60.2 0.1 2.3 2 0 0 2 2 2 1 PX domain SH3_3 PF08239.9 001107606.1_45727001_1 - 1.5e-15 57.1 24.8 0.0031 17.6 0.3 5.6 5 0 0 5 5 5 5 Bacterial SH3 domain hSH3 PF14603.4 001107606.1_45727001_1 - 0.00087 19.6 0.0 0.067 13.6 0.0 2.9 3 0 0 3 3 3 1 Helically-extended SH3 domain DUF1604 PF07713.11 001107606.1_45727001_1 - 0.2 11.3 9.3 1.2 8.9 0.1 4.6 5 0 0 5 5 5 0 Protein of unknown function (DUF1604) SH3_6 PF12913.5 001107606.1_45727001_1 - 6.2 6.3 9.5 0.7 9.3 0.1 3.2 3 0 0 3 3 3 0 SH3 domain (SH3b1 type) DUF3094 PF11293.6 001029864.1_26229001_3 - 0.12 11.9 0.5 1.3 8.7 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) V-set PF07686.15 001107074.1_45722001_3 - 2.1e-07 30.9 0.0 4.3e-07 29.9 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.14 001107074.1_45722001_3 - 1.3e-05 25.0 0.0 8.3e-05 22.4 0.0 1.9 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001107074.1_45722001_3 - 0.00025 21.4 0.0 0.0008 19.8 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001107074.1_45722001_3 - 0.00041 20.3 0.0 0.0017 18.3 0.0 2.0 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001107074.1_45722001_3 - 0.029 14.6 0.0 0.077 13.2 0.0 1.7 1 1 0 1 1 1 0 Immunoglobulin domain CENP-M PF11111.6 178269.3_32923001_1 - 5.3e-11 41.9 0.0 7.7e-11 41.3 0.0 1.2 1 0 0 1 1 1 1 Centromere protein M (CENP-M) CENP-M PF11111.6 178269.3_32923001_3 - 2.3e-48 163.5 0.1 3.2e-48 163.1 0.1 1.1 1 0 0 1 1 1 1 Centromere protein M (CENP-M) Myc_N PF01056.16 001005154.1_49825001_1 - 4.4e-117 391.5 6.8 6.8e-117 390.9 6.8 1.3 1 0 0 1 1 1 1 Myc amino-terminal region Myc-LZ PF02344.13 001005154.1_49825001_1 - 1.6e-16 59.9 11.2 4.4e-16 58.5 11.2 1.8 1 0 0 1 1 1 1 Myc leucine zipper domain HLH PF00010.24 001005154.1_49825001_1 - 1.7e-12 47.0 5.3 3.4e-11 42.8 2.0 2.8 3 0 0 3 3 3 2 Helix-loop-helix DNA-binding domain LIM PF00412.20 001080114.1_26229001_3 - 1.6e-36 124.2 31.9 6.4e-14 51.8 4.8 3.6 3 0 0 3 3 3 3 LIM domain DUF4749 PF15936.3 001080114.1_26229001_3 - 1.5e-24 86.8 0.2 3.1e-24 85.8 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) PDZ PF00595.22 001080114.1_26229001_3 - 1.7e-15 57.0 0.0 3e-15 56.2 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001080114.1_26229001_3 - 0.00034 20.8 0.0 0.00066 19.8 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDCD2_C PF04194.11 001109544.1_45723001_2 - 1.7e-39 135.5 0.5 1.7e-39 135.5 0.5 2.2 2 1 0 2 2 2 1 Programmed cell death protein 2, C-terminal putative domain zf-CSL PF05207.11 001109544.1_45723001_3 - 0.43 10.2 3.9 0.26 10.9 0.3 2.3 2 0 0 2 2 2 0 CSL zinc finger Epimerase PF01370.19 001079914.1_39723001_1 - 1.2e-10 41.1 0.0 2.2e-09 37.0 0.0 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.17 001079914.1_39723001_1 - 1.4e-10 40.5 0.0 1.8e-07 30.3 0.0 2.2 1 1 1 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.11 001079914.1_39723001_1 - 2.7e-09 36.8 0.0 5.7e-09 35.7 0.0 1.4 2 0 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.4 001079914.1_39723001_1 - 2e-08 34.3 0.0 3.9e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.15 001079914.1_39723001_1 - 6.8e-05 22.0 0.0 0.17 10.8 0.0 2.2 2 0 0 2 2 2 2 RmlD substrate binding domain NAD_binding_4 PF07993.10 001079914.1_39723001_1 - 0.00011 21.3 0.1 0.32 10.0 0.0 2.9 2 1 1 3 3 3 2 Male sterility protein GDP_Man_Dehyd PF16363.3 001079914.1_39723001_1 - 0.0017 17.6 0.0 0.0029 16.9 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase adh_short PF00106.23 001079914.1_39723001_1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase Peptidase_M13_N PF05649.11 001002815.2_45727001_1 - 1.1e-120 403.7 0.0 1.5e-120 403.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.19 001002815.2_45727001_1 - 6.5e-72 241.3 0.0 9.9e-72 240.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M48 PF01435.16 001002815.2_45727001_1 - 0.16 11.6 0.0 0.37 10.4 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M48 zf-LYAR PF08790.9 001002815.2_45727001_1 - 0.68 9.7 2.4 23 4.9 0.5 2.6 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger Na_K-ATPase PF00287.16 001098555.1_39725001_2 - 2.4e-98 328.7 0.1 4e-98 327.9 0.1 1.3 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain Ion_trans PF00520.29 133426.2_45724001_1 - 9.1e-40 136.3 6.6 1.1e-39 136.0 6.6 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 133426.2_45724001_1 - 1.1e-20 73.7 0.0 1.8e-20 72.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 133426.2_45724001_1 - 2.5e-11 43.3 4.5 2.5e-11 43.3 4.5 2.0 2 0 0 2 2 2 1 Ion channel Lig_chan PF00060.24 133426.2_45724001_1 - 1 9.1 2.9 1.7 8.4 0.3 2.3 2 1 0 2 2 2 0 Ligand-gated ion channel PKD_channel PF08016.10 133426.2_45724001_1 - 4.3 5.8 9.0 0.48 8.9 4.7 1.6 2 0 0 2 2 2 0 Polycystin cation channel BRICHOS PF04089.12 001039686.1_45722001_2 - 2.6e-25 88.2 0.1 4e-25 87.6 0.1 1.3 1 0 0 1 1 1 1 BRICHOS domain T-box PF00907.20 001106451.1_45723001_1 - 1.5e-78 263.1 0.0 1.9e-78 262.8 0.0 1.1 1 0 0 1 1 1 1 T-box SNF2_N PF00176.21 001107419.1_45729001_1 - 4.3e-79 265.6 0.7 8.1e-79 264.7 0.2 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain SLIDE PF09111.8 001107419.1_45729001_1 - 1.8e-43 147.0 2.4 5e-43 145.6 2.4 1.8 1 0 0 1 1 1 1 SLIDE HAND PF09110.9 001107419.1_45729001_1 - 4.9e-31 107.6 1.0 4.9e-31 107.6 1.0 2.9 2 0 0 2 2 2 1 HAND Helicase_C PF00271.29 001107419.1_45729001_1 - 3.6e-20 72.2 0.0 1.9e-19 70.0 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 001107419.1_45729001_1 - 1e-10 41.8 0.0 4.4e-10 39.7 0.0 2.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.27 001107419.1_45729001_1 - 5.8e-06 26.1 0.0 2.1e-05 24.2 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase HDA2-3 PF11496.6 001107419.1_45729001_1 - 6e-06 25.5 0.0 1.1e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Myb_DNA-binding PF00249.29 001107419.1_45729001_1 - 7.5e-05 22.7 0.3 0.39 10.8 0.0 3.0 2 0 0 2 2 2 2 Myb-like DNA-binding domain DBINO PF13892.4 001107419.1_45729001_1 - 0.00014 22.1 0.1 0.00014 22.1 0.1 3.2 2 0 0 2 2 2 1 DNA-binding domain Ripply PF14998.4 001105892.1_45723001_1 - 2.7e-30 104.7 0.5 4.9e-30 103.9 0.5 1.4 1 0 0 1 1 1 1 Transcription Regulator FAM176 PF14851.4 001071812.2_39723001_1 - 1.6e-55 186.6 0.0 2.4e-55 186.1 0.0 1.3 1 0 0 1 1 1 1 FAM176 family Gal_Lectin PF02140.16 001071812.2_39723001_1 - 1.4e-40 137.4 11.6 1.6e-20 73.2 1.5 2.3 2 0 0 2 2 2 2 Galactose binding lectin domain FMO-like PF00743.17 001082284.1_37926001_2 - 9.4e-294 974.6 0.1 1.1e-293 974.3 0.1 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.4 001082284.1_37926001_2 - 1.8e-18 66.7 0.0 1.4e-12 47.4 0.0 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.4 001082284.1_37926001_2 - 4.3e-11 42.4 0.1 1.2e-08 34.4 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.12 001082284.1_37926001_2 - 6.6e-10 38.6 0.0 6.6e-08 32.0 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.4 001082284.1_37926001_2 - 0.00052 20.1 0.0 0.0012 18.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 001082284.1_37926001_2 - 0.00091 18.8 0.0 0.12 11.9 0.0 2.7 3 0 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.4 001082284.1_37926001_2 - 0.0042 17.0 0.1 7.5 6.4 0.0 3.6 2 2 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.25 001082284.1_37926001_2 - 0.0056 17.1 0.9 0.7 10.4 0.0 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase IlvN PF07991.10 001082284.1_37926001_2 - 0.0076 15.7 0.0 0.1 12.1 0.0 2.2 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.18 001082284.1_37926001_2 - 0.023 14.6 0.0 0.46 10.4 0.0 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Prenylcys_lyase PF07156.12 001082284.1_37926001_2 - 0.045 12.7 0.0 0.098 11.6 0.0 1.4 1 0 0 1 1 1 0 Prenylcysteine lyase Sarcoglycan_1 PF04790.11 001134826.1_45724001_2 - 1.6e-78 263.6 0.0 2.7e-78 262.8 0.0 1.4 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein DUF2345 PF10106.7 001134826.1_45724001_2 - 0.0024 17.7 0.0 0.0058 16.4 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2345) AFP PF02420.13 001081980.1_45724001_1 - 0.017 15.3 2.8 0.2 11.9 2.8 3.1 1 0 0 1 1 1 0 Insect antifreeze protein repeat RabGAP-TBC PF00566.16 001081980.1_45724001_3 - 4.6e-52 176.7 0.0 6.2e-52 176.2 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Pkinase PF00069.23 001108854.1_45727001_1 - 8e-46 156.4 0.0 2e-45 155.1 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 001108854.1_45727001_1 - 1.2e-28 100.0 0.0 2.9e-28 98.7 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.4 001108854.1_45727001_1 - 0.00027 20.2 0.0 0.018 14.3 0.0 2.2 2 0 0 2 2 2 1 Kinase-like APH PF01636.21 001108854.1_45727001_1 - 0.0048 16.7 0.1 3.4 7.4 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.20 001108854.1_45727001_1 - 0.0051 16.3 0.2 0.049 13.1 0.1 2.5 1 1 1 2 2 2 1 RIO1 family TPR_MLP1_2 PF07926.10 001108854.1_45727001_1 - 0.87 9.5 6.2 1.1 9.2 0.3 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein SSF PF00474.15 001101692.1_37925001_1 - 7.8e-171 568.3 25.7 7.8e-171 568.3 25.7 1.9 3 0 0 3 3 3 1 Sodium:solute symporter family TadF PF16964.3 001101692.1_37925001_1 - 0.055 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Putative tight adherence pilin protein F Endomucin PF07010.10 001101692.1_37925001_1 - 6.2 6.6 4.9 28 4.4 1.8 2.2 2 0 0 2 2 2 0 Endomucin TCTP PF00838.15 001098546.2_39722001_3 - 1.7e-83 278.8 0.6 1.9e-83 278.6 0.6 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein AAA_25 PF13481.4 001107599.1_45728001_2 - 2.1e-24 86.0 0.0 3.8e-24 85.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.13 001107599.1_45728001_2 - 6e-14 51.8 0.0 8.3e-14 51.4 0.0 1.2 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain ATPase PF06745.11 001107599.1_45728001_2 - 3e-08 33.2 0.0 5e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 KaiC AAA_22 PF13401.4 001107599.1_45728001_2 - 3.4e-06 27.3 0.0 6.6e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 001107599.1_45728001_2 - 9.3e-06 26.0 0.0 1.9e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain T2SSE PF00437.18 001107599.1_45728001_2 - 0.0014 17.6 0.0 0.0023 16.9 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_29 PF13555.4 001107599.1_45728001_2 - 0.0019 17.7 0.0 0.0044 16.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.4 001107599.1_45728001_2 - 0.0074 16.7 0.0 0.0074 16.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.4 001107599.1_45728001_2 - 0.029 14.6 0.0 0.05 13.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain cobW PF02492.17 001107599.1_45728001_2 - 0.22 11.0 0.1 0.44 10.0 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ARL6IP6 PF15062.4 001107599.1_45728001_3 - 0.072 13.1 1.5 2.1 8.4 0.2 2.3 2 0 0 2 2 2 0 Haemopoietic lineage transmembrane helix E1-E2_ATPase PF00122.18 001101701.1_37927001_3 - 2.2e-55 187.3 1.0 2.2e-55 187.3 1.0 1.9 1 1 1 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 001101701.1_37927001_3 - 2.5e-40 138.0 0.6 2.5e-40 138.0 0.6 2.4 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 001101701.1_37927001_3 - 8.6e-23 80.1 0.0 1.6e-22 79.3 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) H-K_ATPase_N PF09040.9 001101701.1_37927001_3 - 3.2e-22 78.5 11.7 5.4e-22 77.8 11.7 1.4 1 0 0 1 1 1 1 Gastric H+/K+-ATPase, N terminal domain Hydrolase PF00702.24 001101701.1_37927001_3 - 4.3e-16 59.7 0.2 3.9e-07 30.4 0.0 3.1 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 001101701.1_37927001_3 - 6.5e-15 54.4 0.0 1.3e-14 53.5 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 001101701.1_37927001_3 - 7.8e-05 22.4 2.6 0.00035 20.3 1.0 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 001101701.1_37927001_3 - 0.1 12.9 0.2 0.62 10.3 0.2 2.2 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Nucleos_tra2_N PF01773.18 001101701.1_37927001_3 - 10 6.7 11.4 0.71 10.4 0.5 2.9 3 0 0 3 3 3 0 Na+ dependent nucleoside transporter N-terminus Pkinase PF00069.23 001107800.1_45729001_3 - 6.3e-72 242.0 0.0 1e-71 241.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001107800.1_45729001_3 - 6.1e-53 179.6 0.0 8.8e-53 179.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Mst1_SARAH PF11629.6 001107800.1_45729001_3 - 4e-24 84.3 3.1 9.1e-24 83.2 3.1 1.7 1 0 0 1 1 1 1 C terminal SARAH domain of Mst1 Abi_2 PF07751.9 001107800.1_45729001_3 - 0.13 12.4 1.0 0.39 10.8 0.0 1.9 2 0 0 2 2 2 0 Abi-like protein DUF4611 PF15387.4 001107800.1_45729001_3 - 5.5 7.2 7.4 0.29 11.3 1.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) CCDC92 PF14916.4 001083898.1_45724001_1 - 4.6e-22 77.4 2.9 4.6e-22 77.4 2.9 2.5 2 0 0 2 2 2 1 Coiled-coil domain of unknown function Exonuc_VII_L PF02601.13 001083898.1_45724001_1 - 0.044 13.2 6.0 0.073 12.5 6.0 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit IncA PF04156.12 001083898.1_45724001_1 - 0.048 13.3 16.5 0.23 11.1 11.6 2.3 2 0 0 2 2 2 0 IncA protein Sigma54_DBD PF04552.11 001083898.1_45724001_1 - 0.11 12.0 2.1 0.18 11.4 2.1 1.3 1 0 0 1 1 1 0 Sigma-54, DNA binding domain HMMR_N PF15905.3 001083898.1_45724001_1 - 0.3 10.4 18.0 0.44 9.8 18.0 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal CENP-Q PF13094.4 001083898.1_45724001_1 - 0.41 10.7 13.6 2.3 8.2 8.9 2.3 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit ATG16 PF08614.9 001083898.1_45724001_1 - 0.42 10.6 23.3 2.8 7.9 16.2 3.1 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) APG6 PF04111.10 001083898.1_45724001_1 - 0.52 9.5 15.3 0.85 8.8 15.3 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Fez1 PF06818.13 001083898.1_45724001_1 - 1.4 9.1 15.8 1.8 8.8 14.0 1.8 1 1 1 2 2 2 0 Fez1 ADIP PF11559.6 001083898.1_45724001_1 - 1.8 8.5 16.6 4.1 7.3 14.6 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4407 PF14362.4 001083898.1_45724001_1 - 2.5 7.3 6.4 4.3 6.5 6.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) OmpH PF03938.12 001083898.1_45724001_1 - 2.6 7.9 10.6 0.8 9.6 7.1 1.8 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Reo_sigmaC PF04582.10 001083898.1_45724001_1 - 2.7 7.2 6.3 3.6 6.7 2.5 2.5 2 1 1 3 3 3 0 Reovirus sigma C capsid protein Atg14 PF10186.7 001083898.1_45724001_1 - 2.8 6.8 15.6 4.4 6.2 14.9 1.6 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 V_ATPase_I PF01496.17 001083898.1_45724001_1 - 4.6 4.9 4.9 6.3 4.4 4.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF342 PF03961.11 001083898.1_45724001_1 - 8.6 4.7 6.5 13 4.1 6.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Scs3p PF10261.7 001107799.1_45729001_1 - 4.7e-25 88.4 18.9 3e-22 79.2 18.9 2.3 1 1 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM Zip PF02535.20 001108728.1_45726001_2 - 1.6e-67 227.9 0.1 2.9e-67 227.1 0.1 1.4 1 0 0 1 1 1 1 ZIP Zinc transporter PDZ PF00595.22 001082333.1_37925001_1 - 2.1e-18 66.3 0.5 3.5e-18 65.6 0.5 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PH PF00169.27 001082333.1_37925001_1 - 2.6e-10 40.6 0.0 2e-05 24.9 0.0 2.4 2 0 0 2 2 2 2 PH domain PDZ_2 PF13180.4 001082333.1_37925001_1 - 0.0021 18.2 0.1 0.004 17.3 0.1 1.4 1 0 0 1 1 1 1 PDZ domain TP_methylase PF00590.18 001077395.1_26224001_1 - 3.4e-23 82.5 0.0 6e-23 81.8 0.0 1.4 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases ApoM PF11032.6 001040640.1_49822001_1 - 4.1e-112 372.1 0.0 4.7e-112 371.9 0.0 1.0 1 0 0 1 1 1 1 ApoM domain Lipocalin PF00061.21 001040640.1_49822001_1 - 0.067 13.3 0.0 0.12 12.5 0.0 1.3 1 1 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family Stealth_CR4 PF17103.3 001040640.1_49822001_2 - 0.028 14.3 0.0 0.047 13.5 0.0 1.3 1 0 0 1 1 1 0 Stealth protein CR4, conserved region 4 Death PF00531.20 001099923.1_49822001_2 - 7e-15 54.8 0.0 4.9e-14 52.1 0.0 2.2 2 0 0 2 2 2 1 Death domain TIR PF01582.18 001099923.1_49822001_2 - 2.8e-14 53.2 0.1 7.9e-14 51.7 0.1 1.7 1 1 0 1 1 1 1 TIR domain TIR_2 PF13676.4 001099923.1_49822001_2 - 8.9e-13 48.3 0.0 1.6e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 TIR domain Acetyltransf_1 PF00583.23 001108595.1_45723001_1 - 4.2e-12 46.2 0.0 7.2e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.5 001108595.1_45723001_1 - 1.1e-08 34.9 0.0 1.7e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.5 001108595.1_45723001_1 - 6.4e-08 32.8 0.0 1.2e-07 31.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.8 001108595.1_45723001_1 - 7e-08 32.2 0.1 1.2e-07 31.4 0.1 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.5 001108595.1_45723001_1 - 0.021 14.8 0.0 0.035 14.0 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Pkinase PF00069.23 001108101.1_45726001_2 - 2.2e-34 118.9 0.0 3.1e-34 118.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001108101.1_45726001_2 - 8.1e-33 113.7 0.0 1.2e-32 113.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Death PF00531.20 001108101.1_45726001_2 - 2.2e-13 50.0 0.6 6.1e-13 48.6 0.1 1.9 2 0 0 2 2 2 1 Death domain FTA2 PF13095.4 001108101.1_45726001_2 - 0.00072 19.1 0.2 0.0012 18.4 0.2 1.2 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 Cadherin PF00028.15 199508.1_45729001_1 - 1.2e-73 243.4 0.0 3e-16 59.5 0.0 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 199508.1_45729001_1 - 9.9e-63 210.3 4.7 1.6e-62 209.6 4.7 1.3 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 199508.1_45729001_1 - 6.7e-27 93.0 0.3 1.3e-24 85.6 0.0 3.7 4 0 0 4 4 4 1 Cadherin-like Cadherin_C_2 PF16492.3 199508.1_45729001_1 - 5.8e-06 26.9 0.2 1.7e-05 25.4 0.2 1.9 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal CBF PF03914.15 001108523.1_45726001_1 - 2.9e-30 105.3 0.9 7.5e-30 104.0 0.3 2.1 2 0 0 2 2 2 1 CBF/Mak21 family NOC3p PF07540.9 001108523.1_45726001_1 - 1.6e-29 102.0 1.4 1.6e-29 102.0 1.4 2.7 2 0 0 2 2 2 1 Nucleolar complex-associated protein DEAD PF00270.27 001077647.1_45727001_2 - 4.9e-49 166.3 0.0 9.5e-49 165.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001077647.1_45727001_2 - 1.8e-28 99.0 0.2 6.5e-28 97.2 0.1 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 001077647.1_45727001_2 - 0.012 15.5 0.0 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Mob1_phocein PF03637.15 201403.2_26226001_1 - 6.5e-74 247.4 0.0 8.4e-74 247.0 0.0 1.1 1 0 0 1 1 1 1 Mob1/phocein family DUF2475 PF10629.7 001109275.1_45722001_3 - 2e-25 88.6 0.5 4.4e-25 87.5 0.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2475) Glyco_transf_22 PF03901.15 001109000.1_45726001_2 - 7.3e-05 22.0 0.0 9.9e-05 21.6 0.0 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Glyco_transf_22 PF03901.15 001109000.1_45726001_3 - 1.6e-108 363.5 32.6 2.6e-108 362.8 32.6 1.3 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family ASC PF00858.22 001082126.1_37925001_3 - 5.3e-99 331.8 13.2 6.3e-99 331.6 13.2 1.0 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Presenilin PF01080.15 031087.2_45724001_2 - 1e-151 505.1 33.3 1.8e-107 359.4 19.8 2.4 2 1 1 3 3 3 2 Presenilin HGWP PF03578.13 031087.2_45724001_2 - 0.34 10.5 3.3 0.57 9.8 1.7 2.1 2 0 0 2 2 2 0 HGWP repeat DUF4604 PF15377.4 001034148.1_45723001_2 - 0.025 14.9 13.0 0.033 14.5 13.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) NID PF07292.11 001034148.1_45723001_3 - 2.8e-62 207.2 3.4 2.6e-30 104.8 0.5 3.0 3 0 0 3 3 3 2 Nmi/IFP 35 domain (NID) IFP_35_N PF07334.11 001034148.1_45723001_3 - 2.1e-37 126.9 2.8 1.5e-36 124.2 1.7 2.5 2 0 0 2 2 2 1 Interferon-induced 35 kDa protein (IFP 35) N-terminus AA_permease PF00324.19 001109630.1_45729001_1 - 1.6e-62 211.5 33.1 2.6e-40 138.3 5.0 2.2 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.13 001109630.1_45729001_1 - 4.1e-49 167.6 7.0 4e-29 101.7 3.8 3.2 1 1 1 2 2 2 2 Solute carrier family 12 Perilipin PF03036.14 001031778.1_49823001_1 - 7.7e-171 568.3 26.8 1.6e-170 567.2 26.8 1.5 1 1 0 1 1 1 1 Perilipin family SseC PF04888.10 001031778.1_49823001_1 - 0.011 15.1 5.8 0.024 14.0 5.8 1.6 1 1 0 1 1 1 0 Secretion system effector C (SseC) like family DUF1664 PF07889.10 001031778.1_49823001_1 - 0.092 12.6 8.3 0.46 10.4 0.3 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) DUF883 PF05957.11 001031778.1_49823001_1 - 0.57 10.7 19.3 1 9.9 1.3 4.7 3 2 1 4 4 4 0 Bacterial protein of unknown function (DUF883) EzrA PF06160.10 001031778.1_49823001_1 - 2.1 6.3 5.0 2.6 6.0 0.0 2.7 3 0 0 3 3 3 0 Septation ring formation regulator, EzrA KxDL PF10241.7 001031778.1_49823001_1 - 4.4 7.5 6.9 1.1 9.4 0.2 3.0 3 1 0 3 3 3 0 Uncharacterized conserved protein ApoLp-III PF07464.9 001031778.1_49823001_1 - 4.9 7.1 13.6 5.6 6.9 2.1 3.7 2 2 2 4 4 4 0 Apolipophorin-III precursor (apoLp-III) SPARC_Ca_bdg PF10591.7 001108533.2_45723001_1 - 4.1e-32 110.7 0.1 8.9e-32 109.6 0.1 1.6 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Thyroglobulin_1 PF00086.16 001108533.2_45723001_1 - 1.3e-17 63.1 2.5 5.3e-17 61.1 2.5 2.1 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat Kazal_2 PF07648.13 001108533.2_45723001_1 - 7.2e-10 38.8 5.6 2.3e-09 37.1 5.6 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain EF-hand_7 PF13499.4 001108533.2_45723001_1 - 3.9e-05 23.9 0.4 0.00013 22.2 0.1 2.1 2 1 0 2 2 2 1 EF-hand domain pair Kazal_1 PF00050.19 001108533.2_45723001_1 - 0.00034 20.4 4.7 0.00034 20.4 4.7 2.4 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain EF-hand_6 PF13405.4 001108533.2_45723001_1 - 0.012 15.4 0.1 8.1 6.6 0.1 2.7 2 0 0 2 2 2 0 EF-hand domain EF-hand_1 PF00036.30 001108533.2_45723001_1 - 0.13 11.7 0.0 21 4.8 0.0 2.5 2 0 0 2 2 2 0 EF hand V-ATPase_G PF03179.13 001047145.1_29621001_1 - 7.9e-37 125.9 16.8 8.9e-37 125.7 16.8 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit Zein-binding PF04576.13 001047145.1_29621001_1 - 0.24 11.5 18.0 0.13 12.4 16.1 1.6 1 1 1 2 2 2 0 Zein-binding Borrelia_P83 PF05262.9 001047145.1_29621001_1 - 0.94 7.8 11.9 0.96 7.7 11.9 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF3552 PF12072.6 001047145.1_29621001_1 - 1.9 7.8 20.3 2.7 7.2 20.3 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) ATP-synt_B PF00430.16 001047145.1_29621001_1 - 3.4 7.6 26.5 1.1 9.3 18.2 2.0 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) DUF4554 PF15091.4 001047145.1_29621001_1 - 8.5 5.1 8.8 9.4 4.9 8.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) DUF2756 PF10956.6 001047145.1_29621001_1 - 8.5 6.8 20.1 0.21 12.0 10.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2756) Peptidase_M10 PF00413.22 001082209.1_37926001_1 - 2.7e-68 228.7 0.0 6.7e-68 227.4 0.0 1.7 1 1 0 1 1 1 1 Matrixin fn2 PF00040.17 001082209.1_37926001_1 - 1.7e-51 172.0 39.9 1.2e-17 63.8 6.5 3.9 3 0 0 3 3 3 3 Fibronectin type II domain Hemopexin PF00045.17 001082209.1_37926001_1 - 1.4e-44 149.6 6.9 6.2e-15 54.7 0.7 4.6 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.16 001082209.1_37926001_1 - 2e-08 34.2 0.0 4.5e-08 33.1 0.0 1.7 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.22 001082209.1_37926001_1 - 0.0058 16.1 0.1 2.1 7.8 0.1 2.3 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.4 001082209.1_37926001_1 - 0.051 14.0 0.0 0.09 13.2 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.4 001082209.1_37926001_1 - 0.072 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M66 PF10462.7 001082209.1_37926001_1 - 0.13 11.1 0.1 0.2 10.4 0.1 1.2 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_4 PF13583.4 001082209.1_37926001_1 - 0.14 11.6 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like SET PF00856.26 001106167.1_45724001_1 - 2.7e-20 73.3 0.0 5.5e-20 72.3 0.0 1.5 2 0 0 2 2 2 1 SET domain Rubis-subs-bind PF09273.9 001106167.1_45724001_1 - 2.3e-13 50.9 1.2 4.7e-13 49.8 1.2 1.5 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding Ion_trans PF00520.29 001082652.1_37924001_1 - 1.9e-46 158.1 0.5 2.7e-46 157.6 0.5 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 001082652.1_37924001_1 - 1.5e-32 111.7 0.5 9.8e-32 109.1 0.2 2.4 3 0 0 3 3 3 1 BTB/POZ domain Ion_trans_2 PF07885.14 001082652.1_37924001_1 - 4.1e-11 42.6 4.9 1.1e-10 41.2 4.9 1.8 1 0 0 1 1 1 1 Ion channel BTB_3 PF16017.3 001082652.1_37924001_1 - 0.0049 16.8 0.1 0.012 15.5 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain Peptidase_M10 PF00413.22 001082280.1_37924001_1 - 2.8e-63 212.4 0.0 4.6e-63 211.6 0.0 1.4 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 001082280.1_37924001_1 - 3.7e-47 157.9 12.6 5.9e-15 54.8 0.3 4.4 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.16 001082280.1_37924001_1 - 1.4e-11 44.3 0.1 3.7e-11 42.9 0.1 1.7 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.22 001082280.1_37924001_1 - 0.00044 19.8 0.0 0.14 11.7 0.0 2.4 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.4 001082280.1_37924001_1 - 0.055 13.9 0.0 0.095 13.1 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.3 001082280.1_37924001_1 - 0.07 12.2 0.1 0.14 11.2 0.1 1.4 1 0 0 1 1 1 0 Met-zincin Reprolysin_4 PF13583.4 001082280.1_37924001_1 - 0.11 12.0 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like CUB PF00431.18 001106081.1_45729001_2 - 1.3e-181 591.9 3.6 3.3e-40 136.7 0.1 5.2 5 0 0 5 5 5 5 CUB domain Astacin PF01400.22 001106081.1_45729001_2 - 7.3e-73 244.1 1.1 8.8e-73 243.9 0.0 1.7 2 0 0 2 2 2 1 Astacin (Peptidase family M12A) FXa_inhibition PF14670.4 001106081.1_45729001_2 - 1e-16 60.7 42.1 4.9e-09 36.2 8.8 4.0 3 0 0 3 3 3 2 Coagulation Factor Xa inhibitory site EGF_CA PF07645.13 001106081.1_45729001_2 - 3e-08 33.6 29.4 1.2e-06 28.5 6.5 3.3 3 0 0 3 3 3 2 Calcium-binding EGF domain cEGF PF12662.5 001106081.1_45729001_2 - 3.2e-06 26.8 9.1 4.3e-05 23.2 2.0 3.5 3 0 0 3 3 3 2 Complement Clr-like EGF-like CUB_2 PF02408.18 001106081.1_45729001_2 - 0.00028 20.5 3.3 0.31 10.7 0.2 3.7 4 0 0 4 4 4 2 CUB-like domain EGF_3 PF12947.5 001106081.1_45729001_2 - 0.00085 19.3 24.6 0.0043 17.1 6.3 3.8 2 1 1 3 3 3 2 EGF domain Peptidase_M10 PF00413.22 001106081.1_45729001_2 - 0.0018 18.0 0.2 1.1 8.9 0.1 2.5 2 0 0 2 2 2 2 Matrixin hEGF PF12661.5 001106081.1_45729001_2 - 0.033 14.7 0.8 0.033 14.7 0.8 4.8 3 1 0 3 3 3 0 Human growth factor-like EGF Reprolysin_4 PF13583.4 001106081.1_45729001_2 - 0.05 13.1 0.1 0.083 12.4 0.1 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Uroplakin_II PF07353.10 001109523.1_45722001_1 - 2.6e-103 343.0 5.0 2.6e-103 343.0 5.0 1.4 2 0 0 2 2 2 1 Uroplakin II Pur_ac_phosph_N PF16656.3 001109523.1_45722001_1 - 0.036 14.5 0.1 0.051 14.0 0.1 1.3 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain fn3 PF00041.19 001109523.1_45722001_1 - 0.096 12.9 0.1 0.16 12.2 0.1 1.3 1 0 0 1 1 1 0 Fibronectin type III domain LRAT PF04970.11 017060.2_45722001_1 - 3.4e-40 137.1 0.0 4.2e-40 136.8 0.0 1.1 1 0 0 1 1 1 1 Lecithin retinol acyltransferase NLPC_P60 PF00877.17 017060.2_45722001_1 - 0.011 15.6 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 NlpC/P60 family Calici_PP_N PF08405.9 017060.2_45722001_1 - 0.013 14.2 0.0 0.016 13.9 0.0 1.2 1 0 0 1 1 1 0 Viral polyprotein N-terminal Peptidase_C97 PF05903.12 017060.2_45722001_1 - 0.13 12.0 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 PPPDE putative peptidase domain HECT PF00632.23 001106744.1_45729001_1 - 6.9e-79 265.4 0.3 1e-78 264.8 0.3 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Filamin PF00630.17 001106744.1_45729001_1 - 2.5e-10 41.0 0.5 1.6e-07 31.9 0.0 3.2 3 0 0 3 3 3 2 Filamin/ABP280 repeat PH PF00169.27 001107216.1_45729001_2 - 4.3e-40 136.3 14.1 4.2e-12 46.4 0.2 5.6 5 0 0 5 5 5 5 PH domain RhoGAP PF00620.25 001107216.1_45729001_2 - 6.7e-40 136.3 0.0 1.6e-39 135.0 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain ArfGap PF01412.16 001107216.1_45729001_2 - 5.2e-33 113.4 1.0 5.2e-33 113.4 1.0 2.5 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf SAM_1 PF00536.28 001107216.1_45729001_2 - 7.8e-10 38.9 0.1 2.5e-09 37.3 0.1 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_6 PF15406.4 001107216.1_45729001_2 - 2.2e-09 37.4 0.2 5.4e-05 23.3 0.0 3.8 3 0 0 3 3 3 2 Pleckstrin homology domain SAM_2 PF07647.15 001107216.1_45729001_2 - 1.1e-07 31.8 0.1 2.6e-07 30.5 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_3 PF14593.4 001107216.1_45729001_2 - 5.4e-07 29.5 5.1 0.01 15.8 0.0 4.3 4 0 0 4 4 4 2 PH domain PH_8 PF15409.4 001107216.1_45729001_2 - 3.9e-06 26.9 2.0 0.31 11.2 0.1 4.8 4 0 0 4 4 4 1 Pleckstrin homology domain RA PF00788.21 001107216.1_45729001_2 - 6.8e-06 26.5 0.0 2.3e-05 24.8 0.0 2.0 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PH_11 PF15413.4 001107216.1_45729001_2 - 2.3e-05 24.6 9.8 0.87 9.9 1.4 6.1 5 1 0 5 5 5 2 Pleckstrin homology domain PH_2 PF08458.8 001107216.1_45729001_2 - 0.0041 17.3 0.1 1 9.6 0.0 3.0 2 0 0 2 2 2 1 Plant pleckstrin homology-like region Mcp5_PH PF12814.5 001107216.1_45729001_2 - 0.014 15.4 1.3 2.9 7.9 0.0 4.2 4 0 0 4 4 4 0 Meiotic cell cortex C-terminal pleckstrin homology PH_9 PF15410.4 001107216.1_45729001_2 - 0.039 14.2 3.5 26 5.1 0.1 4.8 4 1 0 4 4 4 0 Pleckstrin homology domain PMP22_Claudin PF00822.18 001037774.1_45725001_3 - 2e-30 105.7 6.2 4.2e-30 104.7 6.2 1.6 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001037774.1_45725001_3 - 1.4e-06 28.1 4.9 3.4e-06 26.8 4.9 1.7 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Plexin_cytopl PF08337.10 001108106.1_45729001_2 - 4.8e-223 741.7 6.9 8.6e-223 740.9 6.9 1.4 1 1 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Sema PF01403.17 001108106.1_45729001_2 - 1.1e-61 208.8 0.0 1.8e-61 208.1 0.0 1.3 1 0 0 1 1 1 1 Sema domain TIG PF01833.22 001108106.1_45729001_2 - 3.5e-38 129.4 4.1 1.4e-09 37.7 0.3 6.4 6 0 0 6 6 6 4 IPT/TIG domain PSI PF01437.23 001108106.1_45729001_2 - 1.4e-13 51.0 44.9 5e-08 33.2 16.3 3.8 3 0 0 3 3 3 2 Plexin repeat Peptidase_S64 PF08192.9 001108106.1_45729001_2 - 0.0021 16.5 0.4 0.0034 15.8 0.4 1.2 1 0 0 1 1 1 1 Peptidase family S64 RasGAP PF00616.17 001108106.1_45729001_2 - 0.0072 15.9 0.5 0.027 14.0 0.0 2.0 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase DUF3060 PF11259.6 001108106.1_45729001_2 - 0.1 12.2 0.3 0.45 10.1 0.3 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3060) ARL2_Bind_BART PF11527.6 001108106.1_45729001_2 - 0.16 11.9 0.6 0.46 10.5 0.6 1.7 1 0 0 1 1 1 0 The ARF-like 2 binding protein BART CHD5 PF04420.12 001108106.1_45729001_2 - 4 7.1 4.4 1.9 8.2 0.5 2.3 3 0 0 3 3 3 0 CHD5-like protein Sulfatase PF00884.21 001034927.1_45729001_3 - 1.4e-48 165.7 1.4 2e-48 165.3 1.4 1.2 1 0 0 1 1 1 1 Sulfatase DUF3740 PF12548.6 001034927.1_45729001_3 - 1.5e-48 164.8 0.0 1.5e-48 164.8 0.0 1.9 2 0 0 2 2 2 1 Sulfatase protein DUF4976 PF16347.3 001034927.1_45729001_3 - 0.083 13.0 0.0 9.8 6.4 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4976) Phosphodiest PF01663.20 001034927.1_45729001_3 - 0.17 11.3 2.8 3.7 6.9 2.8 2.3 1 1 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase CCDC73 PF15818.3 001034927.1_45729001_3 - 0.18 9.6 2.3 0.26 9.0 2.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 73 family Cation_efflux PF01545.19 001106404.1_45727001_3 - 3e-48 164.0 12.2 3e-48 164.0 12.2 3.0 4 1 1 5 5 5 1 Cation efflux family tRNA_bind PF01588.18 053757.1_45723001_1 - 1.7e-31 108.0 0.2 3.7e-31 106.9 0.2 1.6 1 0 0 1 1 1 1 Putative tRNA binding domain DUF4094 PF13334.4 053757.1_45723001_1 - 0.99 9.7 5.0 0.53 10.6 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) NUDE_C PF04880.11 053757.1_45723001_1 - 1.1 9.6 9.6 7.1 6.9 9.7 1.9 1 1 1 2 2 2 0 NUDE protein, C-terminal conserved region UCH PF00443.27 001107114.1_45729001_2 - 3.6e-53 180.6 0.3 8.7e-53 179.3 0.1 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 001107114.1_45729001_2 - 8.4e-15 55.0 6.4 6.6e-13 48.8 0.7 3.8 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase UIM PF02809.18 001107114.1_45729001_2 - 0.00017 21.2 9.9 0.0018 17.9 1.3 3.5 3 0 0 3 3 3 2 Ubiquitin interaction motif UBA_4 PF14555.4 001107114.1_45729001_2 - 0.0027 17.3 1.1 0.0071 16.0 0.4 2.1 2 0 0 2 2 2 1 UBA-like domain NDUF_B6 PF09782.7 001044554.2_49822001_3 - 6.3e-51 172.5 2.5 7.7e-51 172.2 2.5 1.1 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit BTB PF00651.29 001105880.1_45729001_3 - 4e-23 81.6 0.0 8.6e-23 80.5 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 001105880.1_45729001_3 - 1.4e-21 75.5 35.3 2.9e-06 27.3 1.9 6.2 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001105880.1_45729001_3 - 1.9e-19 69.0 34.9 4.2e-06 26.8 2.7 6.6 6 1 0 6 6 6 4 Zinc-finger double domain zf-C2H2_4 PF13894.4 001105880.1_45729001_3 - 3.6e-12 45.9 39.8 0.00063 20.2 1.5 6.8 6 0 0 6 6 5 5 C2H2-type zinc finger zf-met PF12874.5 001105880.1_45729001_3 - 6e-06 26.3 26.9 0.028 14.7 1.3 5.6 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.4 001105880.1_45729001_3 - 0.00017 21.3 25.2 0.0025 17.6 0.6 5.6 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2HC_2 PF13913.4 001105880.1_45729001_3 - 0.00045 19.9 6.9 1.1 9.1 0.0 4.9 4 0 0 4 4 4 1 zinc-finger of a C2HC-type zf-C2H2_2 PF12756.5 001105880.1_45729001_3 - 0.013 15.7 22.3 0.039 14.1 8.3 3.8 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.3 001105880.1_45729001_3 - 0.019 14.6 14.5 2.2 8.0 2.0 4.8 4 0 0 4 4 4 0 zinc-finger C2H2-type BolA PF01722.16 001105880.1_45729001_3 - 0.045 13.9 2.4 1.4 9.1 0.2 3.4 2 1 1 3 3 3 0 BolA-like protein Endonuclease_7 PF02945.13 001105880.1_45729001_3 - 3.9 7.3 8.5 2.7 7.8 3.8 3.0 1 1 1 2 2 2 0 Recombination endonuclease VII HNH_5 PF14279.4 001105880.1_45729001_3 - 5.4 6.8 8.3 5.8 6.7 0.1 3.7 3 0 0 3 3 3 0 HNH endonuclease Homeobox PF00046.27 001081572.1_39722001_1 - 4.1e-22 77.6 5.3 6.9e-22 76.9 5.3 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001081572.1_39722001_1 - 0.29 10.9 4.6 0.23 11.2 0.5 2.8 3 0 0 3 3 3 0 Homeobox KN domain Tom37 PF10568.7 001044541.1_49823001_2 - 8.2e-30 103.6 0.0 1.5e-29 102.7 0.0 1.4 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.2 001044541.1_49823001_2 - 2.5e-24 85.7 0.0 4.9e-24 84.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.2 001044541.1_49823001_2 - 9.3e-24 82.9 0.2 1.9e-23 81.9 0.2 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 001044541.1_49823001_2 - 1.4e-05 24.8 0.0 3e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain TRADD_N PF09034.8 001044541.1_49823001_2 - 0.04 13.8 0.0 0.099 12.6 0.0 1.6 1 0 0 1 1 1 0 TRADD, N-terminal domain CutC PF03932.12 001108525.1_45723001_1 - 1.3e-70 236.9 0.0 3.8e-70 235.4 0.0 1.7 2 0 0 2 2 2 1 CutC family C2-set_2 PF08205.10 017076.2_45724001_2 - 5.1e-20 71.2 2.1 2.6e-17 62.5 0.2 2.8 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain ig PF00047.23 017076.2_45724001_2 - 8.1e-18 64.3 2.1 4.2e-06 26.7 0.0 3.7 4 0 0 4 4 4 3 Immunoglobulin domain Ig_3 PF13927.4 017076.2_45724001_2 - 2.6e-17 63.1 3.4 1.4e-06 28.7 0.4 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 017076.2_45724001_2 - 5.2e-16 58.6 0.0 3.7e-15 55.9 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.14 017076.2_45724001_2 - 1.2e-11 44.3 0.0 5.9e-05 22.9 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_2 PF13895.4 017076.2_45724001_2 - 1.3e-09 38.1 1.2 0.00016 21.8 0.1 3.8 3 1 0 3 3 3 2 Immunoglobulin domain C1-set PF07654.13 017076.2_45724001_2 - 0.00087 19.6 0.0 0.0037 17.6 0.0 2.1 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Arf PF00025.19 001031786.1_49822001_1 - 1.9e-63 213.0 0.0 2.2e-63 212.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001031786.1_49822001_1 - 1.8e-10 40.4 0.0 2.3e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 001031786.1_49822001_1 - 1.1e-08 34.6 0.1 2.5e-06 26.8 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.11 001031786.1_49822001_1 - 2.8e-08 33.9 0.0 5.8e-08 32.9 0.0 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001031786.1_49822001_1 - 2.7e-07 30.2 0.0 3.2e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.21 001031786.1_49822001_1 - 6.6e-06 26.1 0.0 1e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001031786.1_49822001_1 - 7.8e-05 22.2 0.1 0.00081 18.8 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 001031786.1_49822001_1 - 0.0042 16.3 0.0 0.0061 15.8 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DNA_Packaging PF11053.6 001031786.1_49822001_1 - 0.035 13.8 0.0 0.051 13.3 0.0 1.2 1 0 0 1 1 1 0 Terminase DNA packaging enzyme Metalloenzyme PF01676.16 001031786.1_49822001_1 - 0.067 12.4 0.0 0.53 9.5 0.0 1.9 1 1 1 2 2 2 0 Metalloenzyme superfamily LIM PF00412.20 001082048.1_37924001_1 - 9e-60 198.6 34.9 8.8e-16 57.8 2.6 4.5 4 0 0 4 4 4 4 LIM domain RE_BstXI PF09552.8 001082048.1_37924001_1 - 0.24 10.4 1.0 9.9 5.1 0.0 2.9 3 0 0 3 3 3 0 BstXI restriction endonuclease Laminin_N PF00055.15 001082048.1_37924001_1 - 3.2 7.2 6.6 0.28 10.6 0.6 2.2 2 1 0 3 3 3 0 Laminin N-terminal (Domain VI) Mab-21 PF03281.12 001109391.1_45727001_1 - 9e-100 333.7 0.0 1.1e-99 333.3 0.0 1.1 1 0 0 1 1 1 1 Mab-21 protein Transglut_core PF01841.17 001108180.1_45729001_2 - 1.9e-14 53.9 0.2 3.4e-14 53.1 0.2 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily Qua1 PF16274.3 133318.1_45724001_1 - 1.5e-28 98.4 1.3 3.7e-28 97.1 1.3 1.7 1 0 0 1 1 1 1 Qua1 domain Sam68-YY PF16568.3 133318.1_45724001_1 - 2.8e-19 69.4 28.7 4.7e-19 68.7 28.7 1.4 1 0 0 1 1 1 1 Tyrosine-rich domain of Sam68 KH_1 PF00013.27 133318.1_45724001_1 - 8.7e-09 35.0 0.0 1.5e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 KH domain STAR_dimer PF16544.3 133318.1_45724001_1 - 0.023 14.2 0.0 0.051 13.0 0.0 1.6 1 0 0 1 1 1 0 Homodimerisation region of STAR domain protein OST3_OST6 PF04756.11 001108566.1_45723001_3 - 7.7e-09 35.2 0.7 1e-08 34.8 0.7 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family BTB PF00651.29 001108720.1_45729001_1 - 2.6e-25 88.7 0.1 5.2e-14 52.3 0.0 2.9 2 1 0 2 2 2 2 BTB/POZ domain BACK PF07707.13 001108720.1_45729001_1 - 2.6e-09 37.0 1.1 4.1e-09 36.3 0.2 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch MFS_1 PF07690.14 031663.2_45726001_1 - 4.2e-35 121.2 28.6 3.1e-30 105.2 22.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 031663.2_45726001_1 - 8.1e-06 24.8 0.2 8.1e-06 24.8 0.2 1.6 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.12 031663.2_45726001_1 - 6e-05 22.4 20.5 0.00021 20.6 20.5 2.1 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Globin PF00042.20 001082133.2_37923001_1 - 1.6e-13 51.0 0.0 2.2e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Globin HELP PF03451.12 001025741.1_45726001_1 - 4e-33 113.0 0.2 7.5e-33 112.1 0.2 1.5 1 0 0 1 1 1 1 HELP motif WD40 PF00400.30 001025741.1_45726001_1 - 7.7e-26 89.7 41.5 0.00017 22.2 0.7 10.9 11 1 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001025741.1_45726001_1 - 9.8e-07 28.9 0.1 0.0013 18.8 0.0 5.1 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain DPPIV_N PF00930.19 001025741.1_45726001_1 - 0.04 12.5 0.0 0.13 10.8 0.0 1.8 2 0 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region SlyX PF04102.10 001025741.1_45726001_1 - 0.2 12.1 1.9 0.25 11.8 0.9 1.6 2 0 0 2 2 2 0 SlyX LRR_8 PF13855.4 001107710.1_45729001_2 - 7.4e-76 249.7 60.5 2.1e-15 56.1 0.9 7.6 1 1 9 10 10 10 9 Leucine rich repeat I-set PF07679.14 001107710.1_45729001_2 - 1.4e-46 156.3 0.0 5.4e-20 71.1 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 001107710.1_45729001_2 - 1.3e-41 140.9 0.0 2.7e-12 47.0 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain LRR_4 PF12799.5 001107710.1_45729001_2 - 3.5e-31 106.5 42.4 4.2e-05 23.7 0.2 9.3 4 1 6 11 11 11 11 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001107710.1_45729001_2 - 1.2e-29 102.7 0.7 3.2e-11 43.2 0.1 3.5 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) Ig_2 PF13895.4 001107710.1_45729001_2 - 7.1e-27 93.4 0.0 1e-07 32.0 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 001107710.1_45729001_2 - 2.5e-24 85.1 0.0 9.2e-07 28.8 0.1 3.6 3 0 0 3 3 3 3 Immunoglobulin domain LRR_9 PF14580.4 001107710.1_45729001_2 - 1.1e-11 44.4 13.4 1.7e-05 24.3 0.3 4.9 1 1 7 8 8 8 7 Leucine-rich repeat V-set PF07686.15 001107710.1_45729001_2 - 2.2e-09 37.3 0.9 0.065 13.3 0.3 5.4 3 2 0 3 3 3 2 Immunoglobulin V-set domain LRR_1 PF00560.31 001107710.1_45729001_2 - 3.5e-08 32.7 27.5 0.11 12.9 0.4 11.2 10 3 0 10 10 10 1 Leucine Rich Repeat C2-set_2 PF08205.10 001107710.1_45729001_2 - 9.1e-08 31.9 0.0 0.0039 17.1 0.0 2.7 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 001107710.1_45729001_2 - 6.8e-06 26.3 0.0 0.18 12.1 0.0 3.8 3 1 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain LRRCT PF01463.22 001107710.1_45729001_2 - 0.00057 20.1 0.0 0.0023 18.2 0.0 2.2 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain Izumo-Ig PF16706.3 001107710.1_45729001_2 - 0.0024 17.7 0.5 16 5.5 0.0 4.0 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain Syndecan PF01034.18 001107710.1_45729001_2 - 0.046 13.5 0.1 0.12 12.2 0.1 1.7 1 0 0 1 1 1 0 Syndecan domain FNIP PF05725.10 001107710.1_45729001_2 - 0.13 12.4 0.3 12 6.0 2.2 3.4 3 1 0 3 3 2 0 FNIP Repeat DUF4781 PF16013.3 001107710.1_45729001_2 - 0.15 10.7 0.1 0.25 10.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) LRR_6 PF13516.4 001107710.1_45729001_2 - 0.41 10.7 46.9 3.3 7.9 0.2 12.3 14 0 0 14 14 13 0 Leucine Rich repeat hSH3 PF14603.4 001109176.1_45726001_1 - 7.9e-52 173.6 25.5 1.2e-42 144.2 1.1 5.6 6 0 0 6 6 6 2 Helically-extended SH3 domain SH3_2 PF07653.15 001109176.1_45726001_1 - 3.8e-13 48.8 0.1 8.9e-10 38.0 0.1 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.26 001109176.1_45726001_1 - 0.00014 21.2 0.3 0.14 11.7 0.0 2.6 2 0 0 2 2 2 2 SH3 domain DUF4651 PF15513.4 001109176.1_45726001_1 - 0.00029 20.4 0.1 0.067 12.9 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4651) SH3_9 PF14604.4 001109176.1_45726001_1 - 0.038 13.7 0.2 5.3 6.9 0.0 2.5 2 0 0 2 2 2 0 Variant SH3 domain SH3_3 PF08239.9 001109176.1_45726001_1 - 0.1 12.8 0.6 0.35 11.0 0.1 2.1 2 0 0 2 2 2 0 Bacterial SH3 domain ATX_III PF08098.9 001109176.1_45726001_1 - 0.13 12.2 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 Anemonia sulcata toxin III family UBN_AB PF14075.4 001109176.1_45726001_1 - 0.68 9.5 12.8 2.1 7.9 0.5 2.5 2 0 0 2 2 2 0 Ubinuclein conserved middle domain Spot_14 PF07084.10 001109176.1_45726001_1 - 1.4 8.9 5.6 28 4.7 3.3 2.6 2 0 0 2 2 2 0 Thyroid hormone-inducible hepatic protein Spot 14 zf-H2C2_2 PF13465.4 001107553.1_45727001_1 - 2e-81 264.9 119.4 9.3e-08 32.1 0.4 18.6 19 0 0 19 19 18 14 Zinc-finger double domain zf-C2H2 PF00096.24 001107553.1_45727001_1 - 4.9e-70 228.2 109.0 2.6e-05 24.3 0.8 16.5 16 0 0 16 16 16 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001107553.1_45727001_1 - 1.8e-54 177.5 106.2 0.00011 22.6 0.8 16.6 16 0 0 16 16 16 16 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001107553.1_45727001_1 - 5.5e-23 80.6 41.3 0.1 12.8 0.0 15.4 16 0 0 16 16 16 6 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001107553.1_45727001_1 - 1.1e-22 79.4 90.0 0.0013 18.5 1.4 16.1 16 0 0 16 16 16 10 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001107553.1_45727001_1 - 4.9e-05 22.9 69.8 0.012 15.2 0.1 13.4 14 0 0 14 14 14 5 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 001107553.1_45727001_1 - 0.0021 18.0 77.7 0.023 14.7 1.9 12.1 5 3 9 14 14 14 6 Zinc ribbon domain zf-C2HC_2 PF13913.4 001107553.1_45727001_1 - 0.021 14.6 1.1 0.021 14.6 1.1 11.9 13 0 0 13 13 12 0 zinc-finger of a C2HC-type BDHCT_assoc PF16204.3 001107553.1_45727001_1 - 0.057 13.0 4.2 13 5.2 0.2 3.3 3 0 0 3 3 3 0 BDHCT-box associated domain on Bloom syndrome protein zf-LYAR PF08790.9 001107553.1_45727001_1 - 0.075 12.8 44.5 0.84 9.5 0.1 11.9 14 0 0 14 14 13 0 LYAR-type C2HC zinc finger DUF3268 PF11672.6 001107553.1_45727001_1 - 0.077 13.2 22.5 3.1 8.0 0.1 6.8 7 0 0 7 7 7 0 zinc-finger-containing domain zinc_ribbon_15 PF17032.3 001107553.1_45727001_1 - 0.18 12.4 44.3 0.58 10.8 0.1 8.1 6 2 0 7 7 7 0 zinc-ribbon family ADK_lid PF05191.12 001107553.1_45727001_1 - 0.25 11.3 30.1 1 9.3 0.8 8.4 6 3 2 8 8 8 0 Adenylate kinase, active site lid YhfH PF14149.4 001107553.1_45727001_1 - 1 9.3 24.8 92 3.0 0.0 9.7 10 0 0 10 10 10 0 YhfH-like protein C1_4 PF07975.10 001107553.1_45727001_1 - 1.3 9.2 50.9 0.93 9.7 0.2 10.2 5 2 9 14 14 14 0 TFIIH C1-like domain zf-met PF12874.5 001107553.1_45727001_1 - 2.5 8.5 79.5 0.29 11.5 0.4 14.0 15 0 0 15 15 15 0 Zinc-finger of C2H2 type HypA PF01155.17 001107553.1_45727001_1 - 5.1 7.0 46.4 4.6 7.2 2.0 7.9 2 2 5 8 8 8 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-AN1 PF01428.14 001107553.1_45727001_1 - 5.7 7.1 72.2 5.3 7.2 0.3 15.4 15 1 0 16 16 16 0 AN1-like Zinc finger Bax1-I PF01027.18 019381.2_45722001_2 - 1.4e-41 142.5 19.8 1.7e-41 142.2 19.8 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 7TMR-DISM_7TM PF07695.9 019381.2_45722001_2 - 0.28 10.9 22.5 0.12 12.1 5.8 2.1 1 1 1 2 2 2 0 7TM diverse intracellular signalling NAD_binding_10 PF13460.4 001106236.1_45722001_3 - 9.6e-37 126.5 0.1 1.2e-36 126.3 0.1 1.1 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.11 001106236.1_45722001_3 - 2.3e-09 37.0 0.1 4.9e-09 36.0 0.1 1.6 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.19 001106236.1_45722001_3 - 2.3e-08 33.7 0.1 4.1e-08 32.8 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.17 001106236.1_45722001_3 - 0.00033 19.6 0.7 0.001 18.0 0.6 1.7 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.22 001106236.1_45722001_3 - 0.052 13.8 0.2 0.12 12.6 0.2 1.7 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain TrkA_N PF02254.16 001106236.1_45722001_3 - 0.13 12.4 0.2 0.24 11.6 0.2 1.4 1 1 0 1 1 1 0 TrkA-N domain Sarcoglycan_2 PF05510.11 001082332.2_37923001_3 - 2.2e-58 197.8 0.0 6.1e-58 196.3 0.0 1.5 1 1 0 1 1 1 1 Sarcoglycan alpha/epsilon LRR_6 PF13516.4 001044696.1_45724001_3 - 6.9e-38 125.3 4.4 9.5e-05 22.0 0.0 7.6 7 0 0 7 7 7 7 Leucine Rich repeat LRR_4 PF12799.5 001044696.1_45724001_3 - 4.6e-06 26.7 11.5 0.035 14.4 0.1 5.6 2 2 5 7 7 7 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001044696.1_45724001_3 - 8.2e-05 22.4 2.9 17 6.2 0.0 6.1 7 1 0 7 7 7 2 Leucine Rich Repeat LRR_8 PF13855.4 001044696.1_45724001_3 - 0.00051 19.6 10.7 0.015 14.9 1.2 4.8 2 2 2 4 4 4 3 Leucine rich repeat Nucleic_acid_bd PF13820.4 001044696.1_45724001_3 - 0.003 17.3 0.0 1.9 8.2 0.0 2.5 1 1 1 2 2 2 2 Putative nucleic acid-binding region Hyphal_reg_CWP PF11765.6 001044696.1_45724001_3 - 0.0074 15.1 6.3 0.081 11.7 3.1 2.3 2 0 0 2 2 2 2 Hyphally regulated cell wall protein N-terminal IL7 PF01415.14 001105747.1_45722001_2 - 3.5e-46 156.4 8.7 4.6e-46 156.1 8.7 1.1 1 0 0 1 1 1 1 Interleukin 7/9 family Trypsin_2 PF13365.4 001109163.1_45727001_2 - 3.4e-17 63.6 0.0 6.1e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S7 PF00949.19 001109163.1_45727001_2 - 0.002 17.8 0.0 0.005 16.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase S7, Flavivirus NS3 serine protease Trypsin PF00089.24 001109163.1_45727001_2 - 0.016 14.9 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 Trypsin Peptidase_S46 PF10459.7 001109163.1_45727001_2 - 0.071 11.6 0.0 0.13 10.7 0.0 1.4 1 0 0 1 1 1 0 Peptidase S46 Frag1 PF10277.7 001107476.1_45724001_2 - 3.2e-49 167.3 19.9 3.8e-49 167.1 19.9 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family DUF4604 PF15377.4 001033894.1_45725001_1 - 0.25 11.6 17.0 0.46 10.8 17.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) JAKMIP_CC3 PF16034.3 001033894.1_45725001_3 - 1.9e-76 256.4 17.1 1.9e-76 256.4 17.1 5.8 3 1 2 5 5 5 1 JAKMIP CC3 domain Synaptonemal_3 PF15191.4 001033894.1_45725001_3 - 1.7 8.4 9.6 0.16 11.6 2.5 2.8 2 0 0 2 2 2 0 Synaptonemal complex central element protein 3 zf-C2H2_4 PF13894.4 001108064.1_45728001_1 - 4.8e-16 57.9 26.8 0.025 15.3 1.0 6.8 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2 PF00096.24 001108064.1_45728001_1 - 5.5e-11 42.2 27.3 0.047 14.0 1.0 6.4 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-FCS PF06467.12 001108064.1_45728001_1 - 2.7e-06 27.1 4.7 1.2 9.0 0.0 5.1 5 0 0 5 5 5 3 MYM-type Zinc finger with FCS sequence motif zf-C2H2_2 PF12756.5 001108064.1_45728001_1 - 0.0063 16.7 5.1 78 3.6 0.0 5.7 6 0 0 6 6 6 0 C2H2 type zinc-finger (2 copies) AnfO_nitrog PF09582.8 001108064.1_45728001_1 - 0.033 13.4 0.0 3.4 6.8 0.0 2.8 3 0 0 3 3 3 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) DUF2256 PF10013.7 001108064.1_45728001_1 - 0.33 11.0 4.3 83 3.3 0.0 4.4 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) Zn-ribbon_8 PF09723.8 001108064.1_45728001_1 - 4.2 7.4 19.4 33 4.6 0.1 6.1 6 0 0 6 6 6 0 Zinc ribbon domain Peptidase_M23 PF01551.20 001108405.1_45722001_3 - 2e-05 24.5 0.0 3e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M23 Homeobox PF00046.27 001080760.1_29622001_1 - 4.2e-22 77.6 5.3 7e-22 76.9 5.3 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001080760.1_29622001_1 - 0.24 11.2 3.5 0.24 11.2 0.5 2.5 3 0 0 3 3 3 0 Homeobox KN domain PAP2 PF01569.19 001107720.1_45726001_1 - 6.2e-21 74.5 1.0 6.2e-21 74.5 1.0 1.7 2 0 0 2 2 2 1 PAP2 superfamily AIMP2_LysRS_bd PF16780.3 001037348.1_45723001_2 - 4.6e-23 80.5 2.1 1.2e-22 79.2 2.1 1.7 1 0 0 1 1 1 1 AIMP2 lysyl-tRNA synthetase binding domain GST_C PF00043.23 001037348.1_45723001_2 - 3.6e-06 27.0 0.0 1e-05 25.5 0.0 1.7 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 001037348.1_45723001_2 - 1.2e-05 25.3 0.0 0.00011 22.2 0.0 2.3 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 001037348.1_45723001_2 - 4.2e-05 23.3 0.0 0.0001 22.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.2 001037348.1_45723001_2 - 0.00015 21.3 0.0 0.0004 20.0 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GTP-bdg_M PF16360.3 001037348.1_45723001_2 - 0.1 13.1 0.0 0.22 12.0 0.0 1.5 1 0 0 1 1 1 0 GTP-binding GTPase Middle Region LRR_8 PF13855.4 001109469.1_45729001_2 - 3.6e-46 154.6 38.5 9.9e-16 57.1 6.2 4.4 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 001109469.1_45729001_2 - 3.8e-23 80.9 37.1 3.9e-05 23.8 0.3 6.4 5 1 1 6 6 6 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001109469.1_45729001_2 - 2.2e-21 76.0 1.6 1.1e-10 41.4 0.1 3.1 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001109469.1_45729001_2 - 2.4e-09 36.8 11.8 0.0005 19.5 0.5 3.4 1 1 0 3 3 3 3 Leucine-rich repeat LRRNT PF01462.16 001109469.1_45729001_2 - 0.021 14.3 2.2 0.075 12.6 2.2 2.0 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain LRR_1 PF00560.31 001109469.1_45729001_2 - 0.84 10.2 37.3 5.6 7.7 1.4 9.7 9 2 1 10 10 10 0 Leucine Rich Repeat LRR_6 PF13516.4 001109469.1_45729001_2 - 1.5 9.0 36.3 5.2 7.2 0.1 9.8 10 0 0 10 10 10 0 Leucine Rich repeat Ig_2 PF13895.4 001107777.1_45729001_2 - 2.5e-115 376.9 22.1 4.4e-11 42.8 0.0 16.0 16 1 1 17 17 16 15 Immunoglobulin domain Ig_3 PF13927.4 001107777.1_45729001_2 - 8.7e-112 365.8 19.6 9.6e-10 38.8 0.4 16.2 16 0 0 16 16 16 14 Immunoglobulin domain I-set PF07679.14 001107777.1_45729001_2 - 6.7e-83 272.8 0.0 2e-08 34.0 0.0 16.7 16 3 0 16 16 16 12 Immunoglobulin I-set domain ig PF00047.23 001107777.1_45729001_2 - 1.5e-73 242.9 20.5 0.00022 21.2 0.3 18.0 17 3 0 17 17 17 13 Immunoglobulin domain V-set PF07686.15 001107777.1_45729001_2 - 4.6e-57 190.7 30.4 1e-08 35.2 0.0 22.6 14 7 8 22 22 22 12 Immunoglobulin V-set domain Ig_4 PF16680.3 001107777.1_45729001_2 - 1.4e-19 70.1 0.0 0.0029 17.8 0.0 11.2 13 0 0 13 13 12 3 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.10 001107777.1_45729001_2 - 1.7e-19 69.5 21.9 1e-12 47.8 2.5 9.7 10 0 0 10 10 10 3 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 001107777.1_45729001_2 - 1.9e-19 69.7 0.0 0.033 14.5 0.0 11.5 13 0 0 13 13 13 4 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 001107777.1_45729001_2 - 2.6e-17 62.5 0.0 0.13 12.2 0.0 12.5 15 0 0 15 15 15 2 Izumo-like Immunoglobulin domain C1-set PF07654.13 001107777.1_45729001_2 - 1e-13 51.4 12.0 0.032 14.6 0.2 9.1 9 1 0 9 9 9 5 Immunoglobulin C1-set domain Receptor_2B4 PF11465.6 001107777.1_45729001_2 - 9.8e-09 35.3 0.3 6.9 6.8 0.0 7.6 8 0 0 8 8 8 2 Natural killer cell receptor 2B4 C2-set PF05790.13 001107777.1_45729001_2 - 5.6e-05 23.1 3.9 4 7.6 0.0 7.6 9 0 0 9 9 9 1 Immunoglobulin C2-set domain BiPBP_C PF06832.10 001107777.1_45729001_2 - 0.0021 18.0 0.4 5.6 7.0 0.0 5.0 7 0 0 7 7 7 1 Penicillin-Binding Protein C-terminus Family SSF PF00474.15 001082699.1_37924001_1 - 3.1e-135 451.0 22.8 4e-135 450.7 22.8 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family HIT PF01230.21 001109607.1_45722001_2 - 1.3e-30 105.8 0.0 1.7e-30 105.5 0.0 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.6 001109607.1_45722001_2 - 2.5e-22 79.4 0.0 3.1e-22 79.1 0.0 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding YEATS PF03366.14 001109057.1_45729001_2 - 5.3e-25 87.1 0.7 1.2e-24 86.0 0.7 1.5 1 0 0 1 1 1 1 YEATS family MRP-S28 PF10213.7 001106628.1_45725001_2 - 3.1e-19 69.5 0.5 5.5e-19 68.7 0.5 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein Na_K-ATPase PF00287.16 001082073.1_37923001_1 - 4.9e-99 330.9 0.2 6.4e-99 330.5 0.2 1.0 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain Ribosomal_L30 PF00327.18 001106903.1_45723001_3 - 6.3e-13 48.3 1.1 1.2e-12 47.4 1.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e DUF829 PF05705.12 001107964.1_45723001_2 - 8.6e-55 186.1 0.0 1e-54 185.9 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) DUF1168 PF06658.10 001098793.1_45723001_2 - 6.1e-47 158.7 16.6 9.9e-47 158.0 16.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) Vfa1 PF08432.8 001098793.1_45723001_2 - 1.8 8.7 18.8 3.2 7.9 18.8 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 FLO_LFY PF01698.14 001098793.1_45723001_2 - 3.6 6.6 10.0 6.4 5.7 10.0 1.3 1 0 0 1 1 1 0 Floricaula / Leafy protein Neur_chan_memb PF02932.14 001098793.1_45723001_2 - 4.6 7.1 5.3 8 6.3 5.3 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Peptidase_C58 PF03543.12 001098793.1_45723001_2 - 6.1 6.4 9.7 9.6 5.7 9.7 1.2 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen Pkinase PF00069.23 001082373.1_37925001_3 - 8.9e-27 94.0 0.0 1.2e-26 93.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001082373.1_37925001_3 - 8.4e-14 51.3 0.0 1e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Defensin_beta PF00711.17 022544.2_45721001_1 - 1.6e-12 47.1 11.3 2.6e-12 46.4 11.3 1.3 1 0 0 1 1 1 1 Beta defensin ESSS PF10183.7 001071810.1_39721001_1 - 2.3e-49 165.8 0.0 2.7e-49 165.6 0.0 1.1 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) PsbL PF02419.15 001107095.1_45726001_1 - 0.52 10.2 2.3 1.1 9.2 2.3 1.5 1 0 0 1 1 1 0 PsbL protein Ank_2 PF12796.5 001107095.1_45726001_2 - 1.6e-22 79.8 2.4 2.6e-12 47.0 0.3 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001107095.1_45726001_2 - 2e-18 66.3 3.3 7.3e-05 23.1 0.0 4.8 3 1 2 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.28 001107095.1_45726001_2 - 3.8e-17 61.8 8.0 0.0059 16.9 0.0 6.3 5 2 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.4 001107095.1_45726001_2 - 7.4e-15 53.4 1.8 0.06 13.8 0.1 6.4 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.4 001107095.1_45726001_2 - 3.9e-11 42.8 6.9 0.0013 19.0 0.1 4.8 3 2 2 5 5 5 4 Ankyrin repeats (many copies) PD-C2-AF1 PF09310.8 001107095.1_45726001_2 - 0.0099 15.2 0.0 0.016 14.5 0.0 1.2 1 0 0 1 1 1 1 POU domain, class 2, associating factor 1 PDEase_I PF00233.17 001106024.1_45726001_1 - 9e-79 264.4 6.0 1.1e-78 264.1 4.2 2.0 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.24 001106024.1_45726001_1 - 3.7e-26 92.1 0.0 1e-12 48.6 0.0 2.4 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.4 001106024.1_45726001_1 - 1.2e-11 44.9 0.0 1.9e-05 24.8 0.0 2.3 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.4 001106024.1_45726001_1 - 9.5e-09 35.5 0.0 0.00063 19.9 0.0 3.2 2 1 0 2 2 2 2 GAF domain OB_NTP_bind PF07717.14 001106024.1_45726001_1 - 0.01 15.8 0.1 0.11 12.5 0.1 2.3 1 1 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DENN PF02141.19 001107547.1_45729001_2 - 1.4e-57 194.5 0.5 1.4e-57 194.5 0.5 1.8 2 0 0 2 2 2 1 DENN (AEX-3) domain uDENN PF03456.16 001107547.1_45729001_2 - 2.9e-17 63.1 0.1 7.9e-17 61.7 0.1 1.8 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.17 001107547.1_45729001_2 - 1.6e-12 47.1 3.2 3.9e-12 45.8 3.2 1.8 1 0 0 1 1 1 1 dDENN domain SEEEED PF14797.4 001107547.1_45729001_2 - 1.5 8.8 10.7 0.2 11.7 4.6 2.5 2 0 0 2 2 2 0 Serine-rich region of AP3B1, clathrin-adaptor complex Pkinase_Tyr PF07714.15 001034997.1_45725001_1 - 1e-24 87.1 0.8 1.8e-24 86.3 0.8 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001034997.1_45725001_1 - 1.3e-24 86.8 1.5 2.9e-24 85.7 1.5 1.5 1 1 0 1 1 1 1 Protein kinase domain PRESAN PF09687.8 001034997.1_45725001_1 - 0.2 12.0 6.7 0.66 10.4 6.8 1.8 2 0 0 2 2 2 0 Plasmodium RESA N-terminal DnaJ PF00226.29 001038595.1_45723001_1 - 1.4e-27 95.4 6.9 2.3e-27 94.7 6.9 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.16 001038595.1_45723001_1 - 3.7e-27 95.1 0.1 4.9e-27 94.7 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.17 001038595.1_45723001_1 - 3.2e-11 43.3 15.1 6.3e-11 42.4 15.1 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.3 001038595.1_45723001_1 - 0.18 11.7 12.7 1.7 8.6 3.8 3.3 1 1 2 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein Cadherin PF00028.15 001037156.1_45729001_1 - 1.3e-76 253.0 0.0 1.3e-15 57.5 0.0 6.4 5 1 1 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001037156.1_45729001_1 - 2.6e-36 123.1 1.2 3.9e-32 109.8 0.0 4.4 5 1 0 5 5 5 2 Cadherin-like Cadherin_tail PF15974.3 001037156.1_45729001_1 - 9e-26 90.6 2.8 1.6e-25 89.8 2.8 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 001037156.1_45729001_1 - 4.8e-24 84.8 0.1 1.4e-23 83.3 0.1 1.9 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001037156.1_45729001_1 - 0.00096 19.0 3.4 1.8 8.5 0.0 4.5 4 0 0 4 4 4 1 Cadherin-like Spem1 PF15670.3 199339.2_26223001_2 - 2.8e-16 59.7 0.0 5.6e-16 58.7 0.0 1.5 1 0 0 1 1 1 1 Spermatid maturation protein 1 Mito_carr PF00153.25 001109515.1_45724001_2 - 4.1e-62 206.0 1.5 3.5e-20 71.6 0.4 3.2 2 1 1 3 3 3 3 Mitochondrial carrier protein SAT PF16073.3 001109515.1_45724001_2 - 0.077 12.4 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Starter unit:ACP transacylase in aflatoxin biosynthesis NDUF_B5 PF09781.7 001071806.1_39722001_1 - 4.3e-88 293.7 0.0 4.8e-88 293.5 0.0 1.0 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit DUF3749 PF12568.6 001071806.1_39722001_1 - 0.12 12.0 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Calreticulin PF00262.16 001109472.1_45725001_3 - 1.4e-158 527.5 9.5 1.4e-158 527.5 9.5 1.5 2 0 0 2 2 2 1 Calreticulin family DUF844 PF05815.9 001109472.1_45725001_3 - 0.21 10.6 0.0 0.32 10.0 0.0 1.1 1 0 0 1 1 1 0 Baculovirus protein of unknown function (DUF844) MFS_2 PF13347.4 001108730.1_45724001_2 - 1.5e-31 109.3 14.0 2.1e-31 108.8 14.0 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1 PF07690.14 001108730.1_45724001_2 - 1.7e-13 50.1 36.0 5.8e-11 41.8 13.1 2.5 2 1 1 3 3 3 2 Major Facilitator Superfamily SEP PF08059.11 001109482.1_45729001_1 - 1.3e-22 80.0 0.2 3.1e-22 78.8 0.2 1.7 1 0 0 1 1 1 1 SEP domain UBX PF00789.18 001109482.1_45729001_1 - 8.4e-11 41.8 0.1 1.5e-10 41.0 0.1 1.5 1 0 0 1 1 1 1 UBX domain Ig_3 PF13927.4 199082.2_45723001_3 - 0.0025 18.2 0.0 0.007 16.8 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain COMM_domain PF07258.12 001109105.1_45722001_3 - 3.9e-16 58.8 0.0 5.7e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 COMM domain SF3a60_bindingd PF12108.6 001109105.1_45722001_3 - 0.48 10.2 2.0 0.96 9.2 2.0 1.5 1 0 0 1 1 1 0 Splicing factor SF3a60 binding domain NTF2 PF02136.18 001108120.1_45725001_3 - 3.2e-28 98.5 0.5 4.5e-28 98.1 0.5 1.2 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain CARM1 PF11531.6 001034088.2_45727001_1 - 4.8e-59 197.3 0.1 7.8e-59 196.6 0.1 1.3 1 0 0 1 1 1 1 Coactivator-associated arginine methyltransferase 1 N terminal PRMT5 PF05185.14 001034088.2_45727001_1 - 2.1e-12 46.7 0.0 3e-12 46.2 0.0 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PrmA PF06325.11 001034088.2_45727001_1 - 6.6e-10 38.7 0.0 1e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.4 001034088.2_45727001_1 - 1.7e-08 34.9 0.0 3.8e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.12 001034088.2_45727001_1 - 1.3e-07 31.2 0.0 2.9e-07 30.1 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_9 PF08003.9 001034088.2_45727001_1 - 3.3e-06 26.1 0.0 4.9e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_11 PF08241.10 001034088.2_45727001_1 - 1.7e-05 25.2 0.0 3.4e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 001034088.2_45727001_1 - 5.2e-05 23.1 0.0 9.4e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 001034088.2_45727001_1 - 6.2e-05 22.7 0.0 0.0001 22.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.5 001034088.2_45727001_1 - 8.1e-05 22.5 0.0 0.00014 21.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001034088.2_45727001_1 - 0.013 16.1 0.0 0.031 14.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain TehB PF03848.12 001034088.2_45727001_1 - 0.028 13.7 0.0 0.044 13.1 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB CMAS PF02353.18 001034088.2_45727001_1 - 0.034 13.3 0.0 0.09 11.9 0.0 1.6 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase Met_10 PF02475.14 001034088.2_45727001_1 - 0.041 13.5 0.0 0.069 12.7 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Cons_hypoth95 PF03602.13 001034088.2_45727001_1 - 0.066 12.7 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_32 PF13679.4 001034088.2_45727001_1 - 0.071 13.0 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain CBP_GIL PF10995.6 001034088.2_45727001_1 - 0.083 11.7 0.1 0.17 10.7 0.1 1.4 2 0 0 2 2 2 0 GGDEF I-site like or GIL domain OAD_gamma PF04277.11 001025686.1_45723001_1 - 1.1 9.7 3.9 1.9 9.0 3.9 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Longin PF13774.4 001025686.1_45723001_2 - 6.4e-26 90.1 0.2 1e-25 89.4 0.2 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.19 001025686.1_45723001_2 - 4.9e-15 55.0 0.5 4.9e-15 55.0 0.5 1.9 2 0 0 2 2 2 1 Synaptobrevin Sec20 PF03908.11 001025686.1_45723001_2 - 1.2 9.0 8.6 0.26 11.1 3.5 2.6 2 1 1 3 3 3 0 Sec20 Arf PF00025.19 053979.2_45723001_3 - 1.6e-64 216.4 0.7 2.1e-64 216.0 0.7 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 053979.2_45723001_3 - 2.7e-14 53.3 0.2 3.9e-14 52.8 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 053979.2_45723001_3 - 5.8e-13 48.6 0.2 7.2e-13 48.3 0.2 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.8 053979.2_45723001_3 - 2e-11 43.5 0.1 2.7e-11 43.1 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 053979.2_45723001_3 - 4.2e-08 32.6 0.5 1.3e-05 24.4 0.2 2.2 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.21 053979.2_45723001_3 - 3.7e-06 26.9 0.1 5.6e-06 26.3 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 053979.2_45723001_3 - 4.1e-06 26.2 0.3 5.3e-06 25.8 0.3 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 053979.2_45723001_3 - 0.055 12.9 0.2 0.22 10.9 0.0 1.8 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain STAT6_C PF14596.4 001044250.1_45726001_3 - 1.1e-96 322.3 19.8 1.7e-96 321.7 19.8 1.3 1 0 0 1 1 1 1 STAT6 C-terminal STAT_bind PF02864.13 001044250.1_45726001_3 - 1e-82 277.7 0.1 1.9e-82 276.8 0.1 1.4 1 0 0 1 1 1 1 STAT protein, DNA binding domain STAT_int PF02865.15 001044250.1_45726001_3 - 4.5e-21 75.4 0.2 1.5e-20 73.8 0.2 2.0 1 0 0 1 1 1 1 STAT protein, protein interaction domain STAT_alpha PF01017.18 001044250.1_45726001_3 - 2.5e-14 53.4 1.6 5e-14 52.4 1.5 1.6 1 1 0 1 1 1 1 STAT protein, all-alpha domain SH2 PF00017.22 001044250.1_45726001_3 - 7.7e-11 41.8 0.0 2.1e-10 40.4 0.0 1.8 2 0 0 2 2 2 1 SH2 domain RRM_1 PF00076.20 001108408.1_45729001_3 - 8.8e-06 25.3 0.0 2.4e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001108408.1_45729001_3 - 0.09 12.8 0.0 0.25 11.4 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif SSF PF00474.15 001082637.1_37927001_3 - 1.3e-38 132.8 21.4 1.7e-38 132.4 21.4 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family C2 PF00168.28 030839.3_45723001_1 - 5.3e-22 77.9 0.0 2.2e-12 47.0 0.0 2.3 2 0 0 2 2 2 2 C2 domain PI3K_C2 PF00792.22 030839.3_45723001_1 - 0.0001 22.2 0.0 0.42 10.5 0.0 2.7 3 0 0 3 3 3 2 Phosphoinositide 3-kinase C2 zf-H2C2_2 PF13465.4 030824.2_26226001_3 - 2.2e-105 340.7 157.5 1.2e-08 34.9 1.1 17.8 17 1 1 18 18 17 16 Zinc-finger double domain zf-C2H2 PF00096.24 030824.2_26226001_3 - 2.6e-51 169.2 148.0 2.5e-05 24.3 0.1 17.4 17 0 0 17 17 17 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 030824.2_26226001_3 - 6.9e-41 135.2 142.3 0.0014 19.2 3.0 17.2 17 0 0 17 17 17 16 C2H2-type zinc finger zf-C2H2_6 PF13912.4 030824.2_26226001_3 - 2.7e-25 87.7 116.1 0.00015 21.5 4.8 16.6 15 0 0 15 15 15 13 C2H2-type zinc finger KRAB PF01352.25 030824.2_26226001_3 - 7.5e-22 76.6 0.0 1.3e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 030824.2_26226001_3 - 3.3e-15 55.8 87.9 0.06 13.5 0.0 15.9 16 0 0 16 16 16 11 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 030824.2_26226001_3 - 6.5e-05 22.5 1.8 0.0009 18.8 0.1 13.2 15 0 0 15 15 15 7 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 030824.2_26226001_3 - 0.00014 21.7 91.8 0.031 14.3 2.1 12.2 4 3 11 15 15 15 6 Zinc ribbon domain Soc PF16855.3 030824.2_26226001_3 - 0.0021 18.3 0.1 54 4.3 0.0 5.5 5 1 1 6 6 6 0 Small outer capsid protein C1_4 PF07975.10 030824.2_26226001_3 - 0.013 15.6 1.1 0.013 15.6 1.1 10.4 6 2 4 10 10 9 0 TFIIH C1-like domain zinc_ribbon_15 PF17032.3 030824.2_26226001_3 - 0.18 12.4 71.0 0.64 10.7 1.4 8.3 3 2 5 9 9 9 0 zinc-ribbon family PLAC8 PF04749.15 001108909.1_45722001_1 - 7.2e-16 58.9 10.3 1.5e-15 57.8 10.3 1.6 1 0 0 1 1 1 1 PLAC8 family Fam20C PF06702.10 001107187.1_45729001_3 - 9.9e-85 283.6 0.0 1.4e-84 283.1 0.0 1.2 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.4 001107187.1_45729001_3 - 0.0087 14.9 0.0 0.013 14.3 0.0 1.2 1 0 0 1 1 1 1 FAM198 protein Synaphin PF05835.10 001109295.1_45727001_2 - 1.2e-44 151.9 7.1 1.7e-44 151.5 7.1 1.2 1 0 0 1 1 1 1 Synaphin protein Homeobox PF00046.27 001081486.1_39722001_1 - 6.9e-23 80.1 5.3 1.1e-22 79.4 5.3 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001081486.1_39722001_1 - 0.0028 17.4 0.1 0.0056 16.4 0.1 1.5 1 0 0 1 1 1 1 Homeobox KN domain DUF3437 PF11919.6 001081486.1_39722001_1 - 0.96 9.3 3.2 2.7 7.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) Homeobox PF00046.27 001106302.1_45723001_1 - 6.7e-21 73.7 3.3 1.1e-20 73.1 3.3 1.3 1 0 0 1 1 1 1 Homeobox domain MFS_1 PF07690.14 001107653.1_45725001_2 - 1.6e-16 60.1 10.7 9.7e-11 41.0 1.4 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.4 001107653.1_45725001_2 - 3.4e-13 48.8 1.0 3.4e-13 48.8 1.0 2.9 3 0 0 3 3 3 2 MFS/sugar transport protein Abhydrolase_1 PF00561.18 001106162.1_45724001_2 - 1.4e-11 44.4 0.0 2e-09 37.4 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001106162.1_45724001_2 - 4e-07 30.7 0.0 6.9e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 001106162.1_45724001_2 - 9.1e-05 21.7 0.0 0.00015 21.0 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF915 PF06028.9 001106162.1_45724001_2 - 0.14 11.3 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Glyco_transf_8 PF01501.18 001082241.1_37924001_3 - 3.8e-18 65.8 0.1 5.4e-16 58.8 0.1 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.6 001082241.1_37924001_3 - 0.018 14.3 0.0 0.027 13.7 0.0 1.2 1 0 0 1 1 1 0 Mannosyltransferase putative Trypsin PF00089.24 001033652.1_45724001_1 - 1.5e-67 227.6 1.8 2.2e-67 227.0 1.8 1.3 1 0 0 1 1 1 1 Trypsin SEA PF01390.18 001033652.1_45724001_1 - 2.9e-24 85.2 1.5 2.9e-24 85.2 1.5 1.6 2 0 0 2 2 2 1 SEA domain Trypsin_2 PF13365.4 001033652.1_45724001_1 - 4e-07 30.9 0.3 7.2e-07 30.1 0.3 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001033652.1_45724001_1 - 2.6e-06 27.7 0.1 5.1e-06 26.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) SOCS PF12610.6 001109274.1_45729001_1 - 2.1e-15 56.7 3.2 2.1e-15 56.7 3.2 2.6 3 0 0 3 3 3 1 Suppressor of cytokine signalling SOCS_box PF07525.14 001109274.1_45729001_1 - 3.8e-09 36.6 0.2 1.2e-08 35.0 0.0 2.0 2 0 0 2 2 2 1 SOCS box SH2 PF00017.22 001109274.1_45729001_1 - 2.5e-08 33.7 0.0 5.2e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 SH2 domain Pkinase PF00069.23 001106774.1_45726001_1 - 4.5e-76 255.6 0.0 6e-76 255.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001106774.1_45726001_1 - 1.4e-43 148.9 0.0 1.8e-43 148.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 001106774.1_45726001_1 - 2.9e-05 23.4 0.2 4.9e-05 22.7 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 001106774.1_45726001_1 - 4.6e-05 22.7 0.0 6.7e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 001106774.1_45726001_1 - 5.2e-05 22.8 0.8 8.5e-05 22.1 0.8 1.2 1 0 0 1 1 1 1 RIO1 family Troponin PF00992.18 001082783.1_37922001_2 - 3.1e-47 160.1 8.7 5e-47 159.4 8.7 1.3 1 0 0 1 1 1 1 Troponin Tup_N PF08581.8 001082783.1_37922001_2 - 0.0022 18.1 1.0 0.0022 18.1 1.0 1.9 2 0 0 2 2 2 1 Tup N-terminal DUF2408 PF10303.7 001082783.1_37922001_2 - 0.0069 16.8 5.2 0.016 15.7 5.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF2408) Transposase_22 PF02994.12 001082783.1_37922001_2 - 0.008 14.9 0.7 0.008 14.9 0.7 1.7 1 1 1 2 2 2 1 L1 transposable element DUF919 PF06034.9 001082783.1_37922001_2 - 0.019 14.7 0.8 0.019 14.7 0.8 2.3 2 1 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) BST2 PF16716.3 001082783.1_37922001_2 - 9.9 6.7 9.9 2.5 8.6 1.7 2.5 3 0 0 3 3 3 0 Bone marrow stromal antigen 2 Metallophos PF00149.26 001101706.1_37923001_1 - 6.3e-40 137.7 0.1 8.5e-40 137.3 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.3 001101706.1_37923001_1 - 5.8e-11 42.5 0.3 1.4e-10 41.3 0.1 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain SH2 PF00017.22 001078675.1_49821001_1 - 2.3e-14 53.1 0.0 3e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 SH2 domain ASC PF00858.22 001082728.1_37926001_2 - 8e-100 334.5 9.0 9.6e-100 334.3 9.0 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Pkinase PF00069.23 031622.2_45729001_3 - 5.9e-69 232.2 0.0 8.1e-69 231.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 031622.2_45729001_3 - 3.6e-25 88.6 0.0 6.6e-25 87.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 031622.2_45729001_3 - 0.016 15.0 0.0 0.028 14.2 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family PRT_C PF08372.8 001105862.1_45729001_2 - 0.76 9.4 2.7 1.4 8.5 2.7 1.3 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal BTB PF00651.29 001105862.1_45729001_3 - 2e-24 85.8 0.1 3e-24 85.2 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 001105862.1_45729001_3 - 1.2e-22 78.9 24.7 2e-05 24.6 1.3 6.2 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001105862.1_45729001_3 - 1.4e-17 63.1 29.0 1.4e-07 31.5 0.3 7.3 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2_4 PF13894.4 001105862.1_45729001_3 - 2.7e-14 52.5 42.0 0.0008 19.9 0.5 6.8 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001105862.1_45729001_3 - 1.6e-13 50.5 4.0 0.00041 20.4 0.2 5.6 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001105862.1_45729001_3 - 3.3e-09 36.4 14.5 0.0024 17.6 0.1 5.7 5 0 0 5 5 5 4 C2H2-type zinc finger zf-met PF12874.5 001105862.1_45729001_3 - 1.1e-07 31.8 16.3 0.0026 17.9 0.5 5.9 5 0 0 5 5 5 2 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 001105862.1_45729001_3 - 0.00038 20.0 10.9 0.86 9.3 0.3 4.5 3 0 0 3 3 3 3 zinc-finger C2H2-type zf-C2HE PF16278.3 001105862.1_45729001_3 - 1.2 9.5 13.4 9.3 6.7 2.2 5.1 2 1 2 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger ASC PF00858.22 001082775.1_37925001_1 - 8e-103 344.4 3.6 1e-102 344.0 3.6 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Sarcoglycan_1 PF04790.11 001082356.1_37924001_3 - 9.4e-63 211.9 0.3 1.2e-62 211.5 0.3 1.1 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein DUF1115 PF06544.10 001108559.1_45725001_1 - 2.9e-09 37.0 0.3 5.2e-09 36.2 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) PRP3 PF08572.8 001108559.1_45725001_3 - 4e-79 265.3 7.3 4e-79 265.3 7.3 2.4 2 1 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.10 001108559.1_45725001_3 - 3.6e-27 95.1 0.1 1.2e-26 93.4 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) PWI PF01480.15 001108559.1_45725001_3 - 1.6e-13 50.6 0.0 3.9e-13 49.4 0.0 1.7 1 0 0 1 1 1 1 PWI domain zf-GRF PF06839.10 001079892.1_45724001_1 - 4.1e-13 49.1 0.9 1.2e-12 47.6 0.9 1.8 1 0 0 1 1 1 1 GRF zinc finger Exo_endo_phos PF03372.21 001079892.1_45724001_1 - 3.7e-12 46.4 0.0 5.6e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.4 001079892.1_45724001_1 - 0.011 15.4 0.0 0.057 13.1 0.0 2.0 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase G-patch PF01585.21 001083337.1_45722001_1 - 6.5e-16 57.8 2.7 1.3e-15 56.8 2.7 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.5 001083337.1_45722001_1 - 4.7e-08 32.9 2.1 4.7e-08 32.9 2.1 3.1 3 0 0 3 3 3 1 G-patch domain PRF PF06875.9 207615.2_45724001_2 - 1.8e-06 27.4 0.0 2.6e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Plethodontid receptivity factor PRF CNTF PF01110.15 207615.2_45724001_2 - 0.00066 19.0 0.0 0.001 18.3 0.0 1.2 1 0 0 1 1 1 1 Ciliary neurotrophic factor Fucokinase PF07959.10 001107429.1_45728001_2 - 2.2e-99 333.1 0.0 3.3e-99 332.5 0.0 1.2 1 0 0 1 1 1 1 L-fucokinase GHMP_kinases_N PF00288.24 001107429.1_45728001_2 - 1.9e-06 27.9 0.6 1.9e-06 27.9 0.6 2.7 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.11 001107429.1_45728001_2 - 0.0042 17.3 0.1 0.018 15.3 0.0 2.1 2 0 0 2 2 2 1 GHMP kinases C terminal WD40 PF00400.30 001134341.1_45729001_3 - 6e-06 26.8 7.2 0.00031 21.3 1.0 4.6 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001134341.1_45729001_3 - 1.4e-05 25.2 0.0 0.044 13.9 0.0 3.9 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 001134341.1_45729001_3 - 0.045 13.5 0.0 0.09 12.5 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Spt20 PF12090.6 001134341.1_45729001_3 - 0.08 12.4 1.2 0.23 10.9 0.9 1.9 2 0 0 2 2 2 0 Spt20 family Ribosomal_S18 PF01084.18 001123140.1_49822001_1 - 3.3e-16 59.1 1.7 4e-16 58.8 0.1 1.9 2 0 0 2 2 2 1 Ribosomal protein S18 RecR PF02132.13 001123140.1_49822001_1 - 0.56 9.7 2.6 2.8 7.5 0.6 2.2 2 0 0 2 2 2 0 RecR protein WD40 PF00400.30 001127297.1_45724001_1 - 0.00043 20.9 0.3 11 6.9 0.0 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001127297.1_45724001_1 - 0.0013 18.9 0.0 1.2 9.3 0.0 3.9 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain BCAS3 PF12490.6 001127297.1_45724001_1 - 0.045 13.1 0.0 0.079 12.3 0.0 1.3 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 3 Big_2 PF02368.16 001127297.1_45724001_1 - 0.16 11.7 0.0 0.37 10.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 2) Radial_spoke PF04712.10 001108205.1_45722001_1 - 3.2e-05 23.0 0.0 5.5e-05 22.2 0.0 1.5 2 1 0 2 2 2 1 Radial spokehead-like protein WD40 PF00400.30 001107525.2_45723001_3 - 0.0026 18.4 1.5 7.6 7.5 0.1 3.8 4 0 0 4 4 4 2 WD domain, G-beta repeat Methyltr_RsmB-F PF01189.15 001107367.2_45725001_2 - 3.1e-46 157.4 0.0 5e-46 156.7 0.0 1.4 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.4 001107367.2_45725001_2 - 4.4e-10 39.4 0.0 8.5e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.17 001107367.2_45725001_2 - 6.6e-07 29.5 0.0 1.5e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase PUA PF01472.18 001107367.2_45725001_2 - 2.1e-05 24.2 0.3 4.3e-05 23.2 0.3 1.5 1 0 0 1 1 1 1 PUA domain PCMT PF01135.17 001107367.2_45725001_2 - 0.005 16.5 0.0 0.0093 15.6 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.16 001107367.2_45725001_2 - 0.0056 15.9 0.0 0.34 10.1 0.0 2.2 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.4 001107367.2_45725001_2 - 0.012 16.2 0.1 0.23 12.1 0.1 2.7 1 1 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.13 001107367.2_45725001_2 - 0.017 14.6 0.0 0.034 13.7 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_11 PF08241.10 001107367.2_45725001_2 - 0.049 14.1 0.0 0.36 11.4 0.0 2.4 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.12 001107367.2_45725001_2 - 0.051 13.0 0.0 0.37 10.2 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_15 PF09445.8 001107367.2_45725001_2 - 0.071 12.8 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_4 PF02390.15 001107367.2_45725001_2 - 0.1 11.9 0.0 3.4 7.0 0.0 2.3 2 0 0 2 2 2 0 Putative methyltransferase zf-RING_2 PF13639.4 001108628.1_45729001_2 - 2.1e-08 34.1 3.8 2.1e-08 34.1 3.8 4.8 5 0 0 5 5 5 1 Ring finger domain zf-RING_11 PF17123.3 001108628.1_45729001_2 - 4e-06 26.3 3.5 1.5e-05 24.5 3.5 2.1 1 0 0 1 1 1 1 RING-like zinc finger PRP21_like_P PF12230.6 001108628.1_45729001_2 - 0.047 13.4 0.0 0.072 12.8 0.0 1.1 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein UPF0172 PF03665.11 001142288.1_26224001_2 - 2.9e-42 144.8 0.1 3.9e-42 144.3 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) UPF0172 PF03665.11 001142288.1_26224001_3 - 1.1e-09 38.5 0.0 1.5e-09 38.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) DUF1011 PF06237.10 001109670.1_45726001_1 - 8.5e-35 118.9 8.3 8.5e-35 118.9 8.3 2.4 3 0 0 3 3 3 1 Protein of unknown function (DUF1011) Urotensin_II PF02083.13 001132940.1_43525001_2 - 2.7 7.7 5.8 0.89 9.2 1.6 2.6 2 0 0 2 2 2 0 Urotensin II Cyclin_N PF00134.21 001132940.1_43525001_3 - 9.3e-19 67.3 0.1 1.5e-18 66.6 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Aida_C2 PF14186.4 001127600.1_45726001_1 - 1.3e-64 216.1 0.2 1.8e-64 215.6 0.2 1.2 1 0 0 1 1 1 1 Cytoskeletal adhesion Aida_N PF08910.8 001127600.1_45726001_1 - 1.4e-39 134.5 0.5 2.3e-39 133.8 0.5 1.3 1 0 0 1 1 1 1 Aida N-terminus Kazal_2 PF07648.13 001107954.1_45728001_1 - 4e-11 42.8 27.5 0.00017 21.5 0.5 5.5 5 0 0 5 5 5 3 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 001107954.1_45728001_1 - 8.5e-10 38.4 21.3 0.0065 16.3 2.9 4.8 2 1 1 3 3 3 3 Kazal-type serine protease inhibitor domain Pacifastin_I PF05375.11 001107954.1_45728001_1 - 1e-05 25.0 1.8 1e-05 25.0 1.8 4.2 2 0 0 2 2 2 1 Pacifastin inhibitor (LCMII) DNA_pol_E_B PF04042.14 001107954.1_45728001_1 - 0.074 12.3 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B Guanylate_cyc PF00211.18 053396.1_45729001_1 - 6e-120 397.4 0.1 3.2e-62 209.3 0.0 2.2 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain DUF1053 PF06327.12 053396.1_45729001_1 - 1.2e-32 112.4 0.0 2.1e-32 111.6 0.0 1.4 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1053) AC_N PF16214.3 053396.1_45729001_1 - 2.1e-17 63.3 8.8 2.1e-17 63.3 8.8 1.9 3 0 0 3 3 3 1 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF2663 PF10864.6 053396.1_45729001_1 - 8.4 6.7 10.2 6.3 7.1 0.2 3.9 2 1 2 4 4 4 0 Protein of unknown function (DUF2663) Med26 PF08711.9 173441.3_32929001_3 - 3.5e-14 52.4 0.0 6.8e-14 51.5 0.0 1.5 1 0 0 1 1 1 1 TFIIS helical bundle-like domain IL10 PF00726.15 001143881.1_45723001_1 - 1.5e-08 34.2 0.8 2.1e-08 33.8 0.8 1.1 1 0 0 1 1 1 1 Interleukin 10 LRR_2 PF07723.11 001143881.1_45723001_1 - 0.34 11.5 2.7 0.91 10.2 0.0 3.1 4 0 0 4 4 4 0 Leucine Rich Repeat adh_short_C2 PF13561.4 001106473.1_45723001_3 - 4.2e-62 209.6 0.3 5.2e-62 209.3 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.23 001106473.1_45723001_3 - 3.5e-49 166.8 0.6 4.5e-49 166.4 0.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.8 001106473.1_45723001_3 - 2.7e-06 27.3 0.5 4.5e-06 26.6 0.5 1.3 1 0 0 1 1 1 1 KR domain AlaDh_PNT_C PF01262.19 001106473.1_45723001_3 - 0.0008 18.6 0.5 0.0013 17.9 0.5 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DUF1776 PF08643.8 001106473.1_45723001_3 - 0.023 13.9 0.1 0.19 10.9 0.1 2.0 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) ADH_zinc_N PF00107.24 001106473.1_45723001_3 - 0.027 14.3 0.0 0.048 13.4 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase 3HCDH_N PF02737.16 001106473.1_45723001_3 - 0.053 13.3 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.12 001106473.1_45723001_3 - 0.061 12.8 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain RRM_5 PF13893.4 138394.3_26227001_3 - 8.1e-61 203.0 1.1 3.8e-54 181.5 0.1 3.2 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.20 138394.3_26227001_3 - 5.8e-21 74.0 0.3 6.7e-06 25.7 0.0 4.2 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 138394.3_26227001_3 - 0.00041 20.0 0.1 2.5 7.9 0.0 3.3 3 0 0 3 3 3 1 Occluded RNA-recognition motif Limkain-b1 PF11608.6 138394.3_26227001_3 - 0.0038 17.1 0.0 2.9 7.9 0.0 3.0 3 0 0 3 3 3 2 Limkain b1 RRM_3 PF08777.9 138394.3_26227001_3 - 0.023 14.6 0.0 0.094 12.6 0.0 2.0 2 0 0 2 2 2 0 RNA binding motif Urb2 PF10441.7 001135708.1_45729001_1 - 5.6e-24 85.1 0.5 5.6e-24 85.1 0.5 4.9 5 1 0 5 5 5 1 Urb2/Npa2 family MRG PF05712.11 012286.2_26224001_3 - 1.5e-52 177.6 0.4 2.1e-52 177.2 0.4 1.2 1 0 0 1 1 1 1 MRG Aph-1 PF06105.10 001131558.1_43529001_3 - 1.7e-83 279.5 19.9 2.5e-83 278.9 19.9 1.3 1 0 0 1 1 1 1 Aph-1 protein DUF544 PF04424.11 001134062.2_43526001_2 - 2.1e-37 127.6 0.0 3.4e-37 126.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF544) RRM_1 PF00076.20 001113370.1_45723001_1 - 7.1e-20 70.5 1.1 1e-19 70.0 1.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001113370.1_45723001_1 - 0.00011 22.1 0.1 0.00033 20.6 0.1 1.8 1 1 0 1 1 1 1 RNA recognition motif RRM_3 PF08777.9 001113370.1_45723001_1 - 0.00022 21.1 0.2 0.00035 20.4 0.2 1.2 1 0 0 1 1 1 1 RNA binding motif PHM7_cyt PF14703.4 001113370.1_45723001_1 - 0.051 13.7 0.0 0.41 10.7 0.0 2.1 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter RRM_occluded PF16842.3 001113370.1_45723001_1 - 0.069 12.9 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif RRM_5 PF13893.4 001113370.1_45723001_1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase_Tyr PF07714.15 001135709.1_45728001_1 - 2.3e-77 259.7 0.0 3.2e-77 259.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.17 001135709.1_45728001_1 - 2.3e-65 219.9 0.0 3.1e-65 219.4 0.0 1.2 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.23 001135709.1_45728001_1 - 5.1e-29 101.3 0.0 6.9e-29 100.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SAM_2 PF07647.15 001135709.1_45728001_1 - 4.2e-15 55.5 0.0 8.5e-15 54.5 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 001135709.1_45728001_1 - 9.1e-15 54.7 0.0 1.6e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) fn3 PF00041.19 001135709.1_45728001_1 - 2.5e-13 50.1 0.0 6.9e-09 35.8 0.0 3.4 3 0 0 3 3 3 2 Fibronectin type III domain EphA2_TM PF14575.4 001135709.1_45728001_1 - 2.9e-11 43.9 0.0 5.1e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Ephrin_rec_like PF07699.11 001135709.1_45728001_1 - 0.0041 16.7 1.1 0.0041 16.7 1.1 2.4 2 0 0 2 2 2 1 Putative ephrin-receptor like zf-HIT PF04438.14 001106203.2_45724001_1 - 5.5e-07 29.2 10.8 5.5e-07 29.2 10.8 1.7 2 0 0 2 2 2 1 HIT zinc finger zf-B_box PF00643.22 001106203.2_45724001_1 - 2 8.5 7.8 3.7 7.6 7.8 1.4 1 0 0 1 1 1 0 B-box zinc finger zf-MYND PF01753.16 001106203.2_45724001_1 - 2 8.4 9.9 4.7 7.2 9.9 1.6 1 0 0 1 1 1 0 MYND finger Calreticulin PF00262.16 001130675.1_26226001_3 - 6.2e-158 525.3 7.2 6.2e-158 525.3 7.2 1.9 2 0 0 2 2 2 1 Calreticulin family CDC45 PF02724.12 001130675.1_26226001_3 - 0.0072 14.6 1.1 0.01 14.1 1.1 1.1 1 0 0 1 1 1 1 CDC45-like protein S-antigen PF05756.9 001130675.1_26226001_3 - 2.1 8.5 9.7 7.1 6.8 6.1 2.6 2 0 0 2 2 2 0 S-antigen protein Paf1 PF03985.11 001130675.1_26226001_3 - 5.5 5.7 20.1 10 4.9 20.1 1.3 1 0 0 1 1 1 0 Paf1 RRM_1 PF00076.20 001111294.1_45729001_3 - 1.9e-33 113.9 0.2 1.3e-15 56.8 0.3 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001111294.1_45729001_3 - 4.4e-10 39.4 0.8 9.4e-05 22.3 0.1 3.3 3 0 0 3 3 3 2 RNA recognition motif Nup35_RRM_2 PF14605.4 001111294.1_45729001_3 - 0.0026 17.5 0.2 0.42 10.5 0.1 2.5 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif CNH PF00780.20 001106329.1_45729001_1 - 2.5e-61 207.6 0.0 3.2e-61 207.2 0.0 1.1 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.23 001106329.1_45729001_1 - 2.7e-42 144.8 0.0 4.1e-42 144.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001106329.1_45729001_1 - 8.7e-26 90.6 0.0 1.4e-25 90.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001106329.1_45729001_1 - 0.13 11.4 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Pkinase PF00069.23 001106329.1_45729001_2 - 1.2e-10 41.1 0.0 1.6e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001106329.1_45729001_2 - 1.9e-05 23.9 0.0 2.7e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase zf-TRAF PF02176.16 001135796.1_29624001_3 - 1.7e-20 73.3 36.0 2.4e-19 69.6 5.7 4.4 3 1 1 4 4 3 3 TRAF-type zinc finger zf-C3HC4_2 PF13923.4 001135796.1_29624001_3 - 7.7e-10 38.3 5.8 7.7e-10 38.3 5.8 3.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001135796.1_29624001_3 - 1.8e-08 34.0 5.6 1.8e-08 34.0 5.6 3.7 3 1 1 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001135796.1_29624001_3 - 2.2e-07 30.5 4.7 2.2e-07 30.5 4.7 4.4 2 1 2 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001135796.1_29624001_3 - 2.6e-07 30.6 4.7 2.6e-07 30.6 4.7 3.8 3 1 0 3 3 2 1 Ring finger domain zf-RING_UBOX PF13445.4 001135796.1_29624001_3 - 7.1e-07 29.0 6.2 7.1e-07 29.0 6.2 2.8 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 001135796.1_29624001_3 - 5e-06 26.4 4.2 5e-06 26.4 4.2 3.4 4 0 0 4 4 1 1 zinc finger of C3HC4-type, RING zf-TRAF_2 PF15965.3 001135796.1_29624001_3 - 2.2e-05 24.7 7.6 2.2e-05 24.7 7.6 4.1 3 1 1 4 4 3 1 TRAF-like zinc-finger zf-RING_5 PF14634.4 001135796.1_29624001_3 - 4.1e-05 23.3 3.9 4.1e-05 23.3 3.9 4.2 3 1 1 4 4 2 1 zinc-RING finger domain SlyX PF04102.10 001135796.1_29624001_3 - 0.00039 20.9 2.9 0.00039 20.9 2.9 2.1 2 0 0 2 2 1 1 SlyX Spc29 PF17082.3 001135796.1_29624001_3 - 0.0023 17.7 1.1 0.004 16.9 1.1 1.3 1 0 0 1 1 1 1 Spindle Pole Component 29 U-box PF04564.13 001135796.1_29624001_3 - 0.0064 16.5 0.1 0.084 12.9 0.0 2.3 2 0 0 2 2 2 1 U-box domain Tropomyosin_1 PF12718.5 001135796.1_29624001_3 - 0.011 15.7 1.1 0.019 15.0 1.1 1.3 1 0 0 1 1 1 0 Tropomyosin like zf-RING_11 PF17123.3 001135796.1_29624001_3 - 0.014 14.9 3.6 0.067 12.8 3.6 2.3 1 0 0 1 1 1 0 RING-like zinc finger DUF16 PF01519.14 001135796.1_29624001_3 - 0.041 14.2 0.9 0.089 13.1 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF16 PspA_IM30 PF04012.10 001135796.1_29624001_3 - 0.044 13.2 1.9 0.079 12.4 1.9 1.4 1 0 0 1 1 1 0 PspA/IM30 family EzrA PF06160.10 001135796.1_29624001_3 - 0.052 11.6 0.7 0.072 11.1 0.7 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA KASH_CCD PF14662.4 001135796.1_29624001_3 - 0.052 13.2 2.2 0.081 12.6 2.2 1.3 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH ADIP PF11559.6 001135796.1_29624001_3 - 0.074 13.0 2.2 0.14 12.1 2.2 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding FliJ PF02050.14 001135796.1_29624001_3 - 0.087 12.9 6.5 0.16 12.0 6.5 1.4 1 0 0 1 1 1 0 Flagellar FliJ protein AAA_13 PF13166.4 001135796.1_29624001_3 - 0.093 11.3 0.3 0.13 10.8 0.3 1.1 1 0 0 1 1 1 0 AAA domain DUF3450 PF11932.6 001135796.1_29624001_3 - 0.098 11.8 0.5 0.16 11.1 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) PI3K_P85_iSH2 PF16454.3 001135796.1_29624001_3 - 0.12 11.8 2.6 0.099 12.1 0.9 1.6 2 0 0 2 2 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Myosin_tail_1 PF01576.17 001135796.1_29624001_3 - 0.13 9.9 2.3 0.17 9.5 2.3 1.1 1 0 0 1 1 1 0 Myosin tail Tropomyosin PF00261.18 001135796.1_29624001_3 - 0.13 11.5 1.9 0.2 10.9 1.9 1.2 1 0 0 1 1 1 0 Tropomyosin HMMR_N PF15905.3 001135796.1_29624001_3 - 0.15 11.4 1.9 0.21 10.9 1.9 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Spc7 PF08317.9 001135796.1_29624001_3 - 0.15 10.8 2.4 0.24 10.1 2.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1664 PF07889.10 001135796.1_29624001_3 - 0.15 11.9 2.4 0.41 10.5 2.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) IncA PF04156.12 001135796.1_29624001_3 - 0.16 11.6 1.4 0.35 10.5 1.4 1.5 1 0 0 1 1 1 0 IncA protein TMF_DNA_bd PF12329.6 001135796.1_29624001_3 - 0.16 11.8 0.5 0.31 10.9 0.5 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding CENP-F_leu_zip PF10473.7 001135796.1_29624001_3 - 0.17 11.7 2.8 0.35 10.8 2.8 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Filament PF00038.19 001135796.1_29624001_3 - 0.22 10.9 3.6 0.38 10.1 3.6 1.3 1 0 0 1 1 1 0 Intermediate filament protein DivIC PF04977.13 001135796.1_29624001_3 - 0.3 10.8 1.3 0.61 9.8 1.3 1.5 1 0 0 1 1 1 0 Septum formation initiator DM PF00751.16 001135796.1_29624001_3 - 0.31 10.9 14.9 0.67 9.8 0.7 3.4 2 1 1 3 3 3 0 DM DNA binding domain Sina PF03145.14 001135796.1_29624001_3 - 0.41 10.5 22.0 0.23 11.3 3.3 3.7 2 1 1 4 4 3 0 Seven in absentia protein family ABC_tran_CTD PF16326.3 001135796.1_29624001_3 - 0.49 10.6 2.0 3.1 8.0 2.1 2.1 1 1 0 1 1 1 0 ABC transporter C-terminal domain PKcGMP_CC PF16808.3 001135796.1_29624001_3 - 2.9 7.7 4.8 3.1 7.6 0.2 2.8 2 1 2 4 4 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Mtf2_C PF14061.4 001100898.1_45726001_3 - 4.7e-27 93.8 0.1 9e-27 92.9 0.1 1.5 1 0 0 1 1 1 1 Polycomb-like MTF2 factor 2 PHD PF00628.27 001100898.1_45726001_3 - 3.4e-16 58.7 28.6 7.3e-12 44.9 8.8 2.6 2 0 0 2 2 2 2 PHD-finger Prok-RING_1 PF14446.4 001100898.1_45726001_3 - 0.00043 20.0 4.1 0.00043 20.0 4.1 3.4 3 0 0 3 3 3 1 Prokaryotic RING finger family 1 DUF4537 PF15057.4 001100898.1_45726001_3 - 0.0021 17.9 0.0 0.0042 16.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) DUF1325 PF07039.9 001100898.1_45726001_3 - 0.027 14.4 0.0 0.073 13.0 0.0 1.7 1 0 0 1 1 1 0 SGF29 tudor-like domain BRCT_assoc PF12820.5 001114949.1_29629001_1 - 4.8e-79 263.7 2.1 4.8e-79 263.7 2.1 3.4 3 0 0 3 3 2 1 Serine-rich domain associated with BRCT BRCT PF00533.24 001114949.1_29629001_1 - 5e-17 62.0 0.0 1.1e-08 35.3 0.0 3.3 3 0 0 3 3 2 2 BRCA1 C Terminus (BRCT) domain zf-C3HC4 PF00097.23 001114949.1_29629001_1 - 8.2e-10 38.3 10.1 3.2e-09 36.4 10.1 2.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001114949.1_29629001_1 - 3.8e-09 36.1 10.7 1.2e-08 34.6 10.7 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001114949.1_29629001_1 - 4.6e-08 33.0 10.3 1.5e-07 31.3 10.3 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 001114949.1_29629001_1 - 6.1e-07 29.1 7.6 1.6e-06 27.8 7.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001114949.1_29629001_1 - 1.4e-06 28.1 8.8 1.4e-06 28.1 8.8 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.4 001114949.1_29629001_1 - 2.2e-06 27.7 8.7 2.2e-06 27.7 8.7 2.5 2 0 0 2 2 1 1 Ring finger domain zf-RING_5 PF14634.4 001114949.1_29629001_1 - 1.7e-05 24.5 8.4 5.7e-05 22.9 8.4 2.0 1 0 0 1 1 1 1 zinc-RING finger domain zf-Nse PF11789.6 001114949.1_29629001_1 - 0.00013 21.6 7.1 0.00041 20.0 7.1 1.8 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.4 001114949.1_29629001_1 - 0.00048 19.8 2.3 0.0011 18.7 2.3 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.3 001114949.1_29629001_1 - 0.00091 19.2 5.6 0.0038 17.2 5.6 2.1 1 0 0 1 1 1 1 zinc RING finger of MSL2 Prok-RING_4 PF14447.4 001114949.1_29629001_1 - 0.0011 18.6 7.6 0.0042 16.8 7.6 2.1 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 BRCT_2 PF16589.3 001114949.1_29629001_1 - 0.0013 18.9 0.0 0.85 9.9 0.0 2.9 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain zf-ANAPC11 PF12861.5 001114949.1_29629001_1 - 0.0025 17.7 1.5 0.006 16.5 1.5 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.5 001114949.1_29629001_1 - 0.011 15.8 4.5 0.057 13.6 4.5 2.3 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.4 001114949.1_29629001_1 - 0.23 11.1 7.0 0.63 9.7 7.0 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3H2C3 PF17122.3 001114949.1_29629001_1 - 1.6 8.7 4.7 5.6 7.0 4.7 2.1 1 1 0 1 1 1 0 Zinc-finger His_Phos_2 PF00328.20 001134901.1_45723001_1 - 8.4e-35 120.7 0.0 9.9e-33 113.9 0.0 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Ank_4 PF13637.4 001108400.2_45722001_2 - 2.4e-15 56.5 0.0 3.7e-06 27.3 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 001108400.2_45722001_2 - 2.6e-11 43.8 0.0 2.3e-10 40.8 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001108400.2_45722001_2 - 2.2e-09 37.3 0.1 1.2e-07 31.7 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.28 001108400.2_45722001_2 - 1.1e-08 35.0 0.7 0.01 16.1 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.4 001108400.2_45722001_2 - 0.00038 20.6 0.1 0.18 12.3 0.0 3.5 3 0 0 3 3 3 1 Ankyrin repeat HTH_18 PF12833.5 001108400.2_45722001_2 - 0.015 15.4 0.0 0.71 10.0 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain LSM14 PF12701.5 001127552.1_45726001_2 - 2e-33 114.2 0.0 3.7e-33 113.3 0.0 1.5 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.8 001127552.1_45726001_2 - 2.3e-31 108.6 8.9 4e-31 107.9 8.9 1.4 1 0 0 1 1 1 1 FDF domain SM-ATX PF14438.4 001127552.1_45726001_2 - 4.3e-08 33.1 0.0 7.3e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain Vinculin PF01044.17 001107248.1_45729001_2 - 0 1645.0 37.4 3.3e-297 988.7 15.7 2.0 1 1 1 2 2 2 2 Vinculin family TipAS PF07739.11 001107248.1_45729001_2 - 5 7.6 13.9 1.5 9.2 0.1 4.5 5 0 0 5 5 5 0 TipAS antibiotic-recognition domain DUF2935 PF11155.6 001107248.1_45729001_2 - 7.9 6.7 6.1 7 6.9 0.5 3.7 4 2 0 4 4 4 0 Domain of unknown function (DUF2935) Calponin PF00402.16 001131129.1_43525001_3 - 3.7e-40 135.1 26.6 1.5e-16 59.6 0.8 4.3 4 0 0 4 4 4 3 Calponin family repeat CH PF00307.29 001131129.1_43525001_3 - 3.5e-20 72.1 0.0 5.1e-20 71.6 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 001131129.1_43525001_3 - 0.013 15.2 0.0 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 CAMSAP CH domain Pur_DNA_glyco PF02245.14 012601.2_45723001_1 - 1.5e-60 203.5 0.0 2.1e-60 203.0 0.0 1.2 1 0 0 1 1 1 1 Methylpurine-DNA glycosylase (MPG) Ras PF00071.20 001123185.1_49822001_1 - 2.4e-56 189.7 0.0 2.7e-56 189.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001123185.1_49822001_1 - 7.4e-20 71.2 0.0 9.8e-20 70.8 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001123185.1_49822001_1 - 8.8e-10 38.2 0.0 9.5e-10 38.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 001123185.1_49822001_1 - 2.1e-06 27.6 0.1 0.0035 17.1 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001123185.1_49822001_1 - 5.7e-06 25.9 0.1 4.4e-05 23.0 0.1 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001123185.1_49822001_1 - 0.0002 21.3 0.0 0.00028 20.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.3 001123185.1_49822001_1 - 0.0078 16.1 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain FeoB_N PF02421.16 001123185.1_49822001_1 - 0.013 14.9 0.1 0.054 12.9 0.1 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B ArgK PF03308.14 001123185.1_49822001_1 - 0.036 12.9 0.1 0.51 9.1 0.0 2.1 2 0 0 2 2 2 0 ArgK protein Glyco_transf_54 PF04666.11 001127533.1_45725001_1 - 9.7e-135 447.9 0.1 1.4e-134 447.4 0.1 1.1 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region STAR_dimer PF16544.3 001127533.1_45725001_1 - 0.3 10.6 1.8 0.29 10.6 0.2 1.8 2 0 0 2 2 2 0 Homodimerisation region of STAR domain protein ST7 PF04184.10 001168716.1_40424001_1 - 0 1073.1 1.9 0 1072.9 1.9 1.0 1 0 0 1 1 1 1 ST7 protein TPR_6 PF13174.4 001168716.1_40424001_1 - 0.00061 20.1 0.0 0.0033 17.8 0.0 2.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.15 001168716.1_40424001_1 - 0.0051 16.7 0.2 4.8 7.4 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat Clathrin PF00637.18 001168716.1_40424001_1 - 0.06 13.1 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Region in Clathrin and VPS TPR_19 PF14559.4 001168716.1_40424001_1 - 0.14 12.5 4.9 0.41 11.0 0.5 3.3 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.26 001168716.1_40424001_1 - 1.4 8.7 3.4 1.1e+02 2.8 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.4 001168716.1_40424001_1 - 2.3 9.1 8.2 14 6.6 0.0 4.6 3 2 2 5 5 5 0 Tetratricopeptide repeat Pkinase PF00069.23 022187.1_45725001_3 - 9e-71 238.2 0.0 1.1e-70 237.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 022187.1_45725001_3 - 3.5e-37 127.9 0.0 5.5e-37 127.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.16 022187.1_45725001_3 - 9.1e-29 99.3 0.0 5.9e-13 48.7 0.0 2.5 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.4 022187.1_45725001_3 - 6.3e-09 35.4 0.0 0.00014 21.2 0.0 2.5 1 1 1 2 2 2 2 Kinase-like APH PF01636.21 022187.1_45725001_3 - 0.098 12.4 0.2 0.31 10.8 0.1 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Trypsin PF00089.24 001133375.1_43525001_3 - 7.2e-49 166.4 0.0 1.1e-48 165.8 0.0 1.3 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 001133375.1_43525001_3 - 8.4e-49 164.4 0.0 4.3e-28 97.7 0.0 2.4 2 0 0 2 2 2 2 CUB domain Sushi PF00084.18 001133375.1_43525001_3 - 9.6e-20 70.8 17.0 2.4e-13 50.3 0.5 3.6 3 0 0 3 3 3 2 Sushi repeat (SCR repeat) FXa_inhibition PF14670.4 001133375.1_43525001_3 - 5.4e-10 39.3 8.6 9.5e-10 38.5 6.2 2.6 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site cEGF PF12662.5 001133375.1_43525001_3 - 1.5e-06 27.9 5.5 0.00017 21.3 2.9 3.0 2 0 0 2 2 2 2 Complement Clr-like EGF-like EGF_CA PF07645.13 001133375.1_43525001_3 - 1.1e-05 25.4 6.0 1.1e-05 25.4 6.0 3.4 3 1 0 3 3 3 1 Calcium-binding EGF domain hEGF PF12661.5 001133375.1_43525001_3 - 0.0011 19.5 6.6 0.0013 19.2 3.6 2.8 2 0 0 2 2 2 1 Human growth factor-like EGF Trypsin_2 PF13365.4 001133375.1_43525001_3 - 0.0049 17.6 0.0 0.028 15.1 0.0 2.1 1 1 0 1 1 1 1 Trypsin-like peptidase domain EGF PF00008.25 001133375.1_43525001_3 - 0.0056 16.8 6.0 0.0056 16.8 6.0 2.5 2 0 0 2 2 2 1 EGF-like domain CUB_2 PF02408.18 001133375.1_43525001_3 - 0.035 13.7 0.0 3.5 7.3 0.0 2.5 2 0 0 2 2 2 0 CUB-like domain eIF-3c_N PF05470.10 001100662.1_45727001_2 - 1.3e-267 888.9 39.8 1.6e-198 660.7 21.4 2.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.25 001100662.1_45727001_2 - 5.4e-17 62.1 0.7 1.6e-16 60.6 0.1 2.2 2 0 0 2 2 2 1 PCI domain Ndc1_Nup PF09531.8 001100662.1_45727001_2 - 0.64 8.5 5.6 2.8 6.4 5.2 2.1 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Band_7 PF01145.23 001106088.2_45727001_2 - 1.5e-18 67.3 0.0 2.5e-18 66.6 0.0 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family ETRAMP PF09716.8 001106088.2_45727001_2 - 0.0023 17.8 1.0 0.1 12.6 0.8 2.5 2 1 0 2 2 2 1 Malarial early transcribed membrane protein (ETRAMP) V-ATPase_G PF03179.13 001145380.1_49821001_1 - 7.9e-37 125.9 16.8 8.9e-37 125.7 16.8 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit Zein-binding PF04576.13 001145380.1_49821001_1 - 0.24 11.6 18.0 0.13 12.4 16.1 1.6 1 1 1 2 2 2 0 Zein-binding Borrelia_P83 PF05262.9 001145380.1_49821001_1 - 0.94 7.8 11.9 0.96 7.7 11.9 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF3552 PF12072.6 001145380.1_49821001_1 - 1.9 7.8 20.3 2.7 7.2 20.3 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) ATP-synt_B PF00430.16 001145380.1_49821001_1 - 3.4 7.6 26.5 1.1 9.3 18.2 2.0 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) DUF2756 PF10956.6 001145380.1_49821001_1 - 8.5 6.8 20.1 0.21 12.0 10.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2756) DUF4554 PF15091.4 001145380.1_49821001_1 - 8.5 5.1 8.8 9.4 4.9 8.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) EB1 PF03271.15 001132764.1_43526001_2 - 2.1e-17 63.0 0.7 6e-17 61.5 0.5 1.9 2 0 0 2 2 2 1 EB1-like C-terminal motif CH PF00307.29 001132764.1_43526001_2 - 6.4e-13 48.7 0.3 1.2e-12 47.9 0.3 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 001132764.1_43526001_2 - 0.03 14.0 0.6 0.083 12.6 0.0 2.0 2 0 0 2 2 2 0 CAMSAP CH domain TH1 PF04858.11 001113698.1_49825001_3 - 2.3e-282 937.7 0.2 2.7e-282 937.5 0.2 1.0 1 0 0 1 1 1 1 TH1 protein FGGY_C PF02782.14 001013932.2_45724001_1 - 4.4e-49 166.8 0.1 6.8e-49 166.2 0.1 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.19 001013932.2_45724001_1 - 1.4e-26 93.4 0.0 2e-26 92.9 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.18 001013932.2_45724001_1 - 0.011 15.1 0.0 0.4 10.0 0.0 2.5 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family AnmK PF03702.12 001013932.2_45724001_1 - 0.14 11.1 0.1 4.4 6.2 0.0 2.2 2 0 0 2 2 2 0 Anhydro-N-acetylmuramic acid kinase ECH_2 PF16113.3 001013932.2_45724001_1 - 0.17 11.3 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase NeuB PF03102.12 001106655.2_45725001_3 - 5.3e-77 258.4 0.0 8.1e-77 257.8 0.0 1.3 1 0 0 1 1 1 1 NeuB family SAF PF08666.10 001106655.2_45725001_3 - 2.2e-06 28.1 0.1 3.9e-06 27.3 0.1 1.5 1 0 0 1 1 1 1 SAF domain S_100 PF01023.17 001108557.2_45723001_1 - 1.1e-09 37.7 1.0 1.7e-09 37.1 1.0 1.3 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_5 PF13202.4 001108557.2_45723001_1 - 0.00041 19.6 0.0 0.00087 18.6 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.4 001108557.2_45723001_1 - 0.00057 20.2 0.0 0.001 19.3 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.4 001108557.2_45723001_1 - 0.0027 17.3 0.1 0.0048 16.5 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 001108557.2_45723001_1 - 0.0033 16.7 0.1 0.021 14.2 0.0 2.1 2 0 0 2 2 2 1 EF hand PAXNEB PF05625.9 001115047.2_45724001_2 - 6.4e-109 364.3 0.0 7.2e-109 364.1 0.0 1.0 1 0 0 1 1 1 1 PAXNEB protein MEA1 PF06910.9 001110429.1_49823001_1 - 9.7e-112 370.3 9.3 1.6e-111 369.6 9.3 1.3 1 0 0 1 1 1 1 Male enhanced antigen 1 (MEA1) Peptidase_C54 PF03416.17 001123079.1_49824001_1 - 7.6e-105 349.9 0.0 9.6e-105 349.6 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 LRR_8 PF13855.4 001100722.1_45726001_3 - 2.2e-66 219.4 61.3 8.5e-13 47.7 2.8 6.8 1 1 7 8 8 8 8 Leucine rich repeat LRR_5 PF13306.4 001100722.1_45726001_3 - 3.9e-24 84.9 0.0 1.5e-10 41.0 0.0 3.1 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_4 PF12799.5 001100722.1_45726001_3 - 3.1e-22 78.1 25.2 0.00022 21.4 2.7 6.7 5 1 0 6 6 6 5 Leucine Rich repeats (2 copies) I-set PF07679.14 001100722.1_45726001_3 - 4.1e-13 49.1 0.0 6.8e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001100722.1_45726001_3 - 1.3e-10 41.6 0.0 2.5e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001100722.1_45726001_3 - 4.8e-07 29.9 0.0 8.9e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain LRR_9 PF14580.4 001100722.1_45726001_3 - 1.4e-06 27.8 10.1 0.00066 19.1 1.9 3.4 2 2 1 3 3 3 3 Leucine-rich repeat ig PF00047.23 001100722.1_45726001_3 - 1.5e-06 28.1 0.0 3e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.31 001100722.1_45726001_3 - 0.00013 21.8 27.9 7.5 7.3 0.0 11.0 11 1 1 12 12 12 1 Leucine Rich Repeat LRRNT PF01462.16 001100722.1_45726001_3 - 0.0034 16.9 7.1 0.0076 15.8 3.4 3.0 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain V-set PF07686.15 001100722.1_45726001_3 - 0.15 12.1 0.0 0.45 10.6 0.0 1.9 1 1 0 1 1 1 0 Immunoglobulin V-set domain LRR_6 PF13516.4 001100722.1_45726001_3 - 0.95 9.6 37.9 3.6 7.8 0.1 9.0 12 0 0 12 12 11 0 Leucine Rich repeat Pex19 PF04614.10 001107375.2_45725001_3 - 1.1e-56 192.2 8.0 1.7e-56 191.6 8.0 1.2 1 0 0 1 1 1 1 Pex19 protein family Rod-binding PF10135.7 001107375.2_45725001_3 - 0.075 13.5 0.2 0.21 12.1 0.2 1.7 1 0 0 1 1 1 0 Rod binding protein GAS PF13851.4 001107375.2_45725001_3 - 0.53 9.5 2.9 0.34 10.1 0.9 1.6 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Jiv90 PF14901.4 053690.2_45726001_2 - 8.9e-37 125.1 0.3 2.2e-36 123.8 0.3 1.7 1 0 0 1 1 1 1 Cleavage inducing molecular chaperone DnaJ PF00226.29 053690.2_45726001_2 - 1.8e-19 69.5 0.1 3.1e-19 68.7 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain Pkinase PF00069.23 001109307.2_45725001_3 - 7.6e-35 120.4 0.0 1.2e-34 119.7 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001109307.2_45725001_3 - 8.5e-27 93.9 0.0 5.4e-24 84.7 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.4 001109307.2_45725001_3 - 0.00029 20.1 0.0 0.00045 19.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like ASXH PF13919.4 001109307.2_45725001_3 - 0.061 13.2 0.1 0.12 12.3 0.1 1.3 1 0 0 1 1 1 0 Asx homology domain Glyco_transf_29 PF00777.16 031695.2_45727001_3 - 8.9e-84 280.9 0.1 1.2e-83 280.5 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) G_glu_transpept PF01019.19 031695.2_45727001_3 - 0.0099 14.5 0.0 0.013 14.1 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase HAD_2 PF13419.4 012080.4_26225001_3 - 2.2e-22 79.9 0.0 2.8e-22 79.5 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.24 012080.4_26225001_3 - 4.1e-13 50.0 0.0 1.4e-12 48.2 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.4 012080.4_26225001_3 - 0.00013 21.8 0.0 0.00022 21.1 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.4 012080.4_26225001_3 - 0.027 14.5 0.0 0.72 9.9 0.0 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase HMG_box PF00505.17 001107902.1_45725001_3 - 2e-25 88.8 1.4 3.3e-25 88.2 1.4 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box Sox17_18_mid PF12067.6 001107902.1_45725001_3 - 2.1e-19 69.2 1.7 2.1e-19 69.2 1.7 2.3 2 0 0 2 2 2 1 Sox 17/18 central domain HMG_box_2 PF09011.8 001107902.1_45725001_3 - 9.1e-11 42.1 1.1 1.7e-10 41.2 1.1 1.5 1 0 0 1 1 1 1 HMG-box domain TNRC6-PABC_bdg PF16608.3 018996.3_26229001_1 - 1.7e-100 336.4 38.2 3.4e-73 246.8 7.7 7.6 6 2 2 8 8 8 2 TNRC6-PABC binding domain M_domain PF12938.5 018996.3_26229001_1 - 1.1e-71 241.4 37.5 1.1e-71 241.4 37.5 3.9 3 1 1 5 5 5 1 M domain of GW182 Ago_hook PF10427.7 018996.3_26229001_1 - 2.8e-21 76.6 27.5 2.8e-21 76.6 27.5 10.5 4 2 3 8 8 8 1 Argonaute hook UBA PF00627.29 018996.3_26229001_1 - 8.6e-06 25.4 0.0 1.7e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain RRM_1 PF00076.20 018996.3_26229001_1 - 0.00024 20.7 0.0 0.00044 19.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 018996.3_26229001_1 - 0.027 14.2 0.0 0.049 13.4 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif THOC7 PF05615.11 018996.3_26229001_1 - 1.4 9.1 6.8 2.8 8.1 6.8 1.4 1 0 0 1 1 1 0 Tho complex subunit 7 Biopterin_H PF00351.19 012619.2_45725001_3 - 7.1e-174 577.4 0.0 9.5e-174 577.0 0.0 1.2 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.23 012619.2_45725001_3 - 2.9e-08 33.2 0.0 5.8e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 ACT domain Arf PF00025.19 001131824.1_43524001_1 - 4.2e-74 247.6 0.3 5.3e-74 247.3 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001131824.1_43524001_1 - 9.6e-14 51.1 0.0 1.3e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.20 001131824.1_43524001_1 - 3.8e-13 49.2 0.0 5.1e-13 48.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001131824.1_43524001_1 - 5.1e-13 49.2 0.0 7.2e-13 48.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.18 001131824.1_43524001_1 - 6.3e-10 38.6 1.6 7.7e-07 28.5 0.2 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 001131824.1_43524001_1 - 1.6e-09 37.4 0.0 2.1e-09 37.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001131824.1_43524001_1 - 0.0013 18.6 0.0 0.0023 17.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.16 001131824.1_43524001_1 - 0.023 13.9 0.1 0.071 12.3 0.1 1.7 2 0 0 2 2 2 0 6-phosphofructo-2-kinase BTB PF00651.29 001126302.1_45724001_3 - 5.4e-25 87.6 0.0 7.7e-25 87.2 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_4 PF13894.4 001126302.1_45724001_3 - 1.6e-11 43.8 39.0 0.00026 21.4 3.4 5.6 5 0 0 5 5 5 4 C2H2-type zinc finger zf-H2C2_2 PF13465.4 001126302.1_45724001_3 - 2.9e-09 36.8 35.2 3.3e-07 30.3 1.5 6.1 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2 PF00096.24 001126302.1_45724001_3 - 4.9e-06 26.6 39.8 0.0014 18.8 1.7 5.2 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.6 001126302.1_45724001_3 - 0.0096 16.1 10.6 0.068 13.4 0.3 4.2 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.9 001126302.1_45724001_3 - 0.095 12.5 0.3 0.095 12.5 0.3 3.1 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zf-C2H2_6 PF13912.4 001126302.1_45724001_3 - 1.5 8.7 22.5 1.9 8.4 0.8 4.3 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001126302.1_45724001_3 - 5.7 6.7 23.9 0.91 9.2 0.5 4.4 4 0 0 4 4 4 0 zinc-finger C2H2-type Pkinase PF00069.23 001168732.1_40429001_3 - 1.1e-71 241.2 0.0 1.5e-71 240.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001168732.1_40429001_3 - 8.1e-53 179.2 0.0 1.1e-52 178.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Mst1_SARAH PF11629.6 001168732.1_40429001_3 - 3.4e-24 84.5 3.4 6e-24 83.7 3.4 1.4 1 0 0 1 1 1 1 C terminal SARAH domain of Mst1 EMI PF07546.11 001109901.2_45725001_2 - 2.2e-15 57.0 3.9 5.2e-15 55.8 3.9 1.7 1 0 0 1 1 1 1 EMI domain Reo_sigmaC PF04582.10 001109901.2_45725001_2 - 2.9e-05 23.5 12.3 0.29 10.3 6.9 4.3 3 1 1 4 4 4 2 Reovirus sigma C capsid protein FlaC_arch PF05377.9 001109901.2_45725001_2 - 0.00032 20.9 0.7 13 6.1 0.0 6.3 5 2 2 7 7 6 0 Flagella accessory protein C (FlaC) HMMR_N PF15905.3 001109901.2_45725001_2 - 0.00051 19.5 3.8 0.023 14.0 0.0 3.2 2 1 0 3 3 3 1 Hyaluronan mediated motility receptor N-terminal DUF2408 PF10303.7 001109901.2_45725001_2 - 0.0018 18.7 2.6 0.11 13.0 0.3 3.6 2 1 0 2 2 2 1 Protein of unknown function (DUF2408) DUF1664 PF07889.10 001109901.2_45725001_2 - 0.0022 17.8 13.5 0.25 11.2 0.2 6.2 4 2 2 8 8 7 2 Protein of unknown function (DUF1664) Spc7 PF08317.9 001109901.2_45725001_2 - 0.0038 16.0 12.4 0.045 12.5 0.4 4.2 2 1 2 4 4 4 1 Spc7 kinetochore protein Golgin_A5 PF09787.7 001109901.2_45725001_2 - 0.0051 16.2 0.6 0.0051 16.2 0.6 3.3 3 1 1 4 4 3 1 Golgin subfamily A member 5 Rootletin PF15035.4 001109901.2_45725001_2 - 0.0058 16.6 2.2 0.0058 16.6 2.2 3.5 2 1 0 3 3 3 1 Ciliary rootlet component, centrosome cohesion NPV_P10 PF05531.10 001109901.2_45725001_2 - 0.0062 16.8 10.9 24 5.3 0.0 7.2 6 2 3 9 9 7 0 Nucleopolyhedrovirus P10 protein CorA PF01544.16 001109901.2_45725001_2 - 0.015 14.5 2.7 0.27 10.4 0.4 3.0 1 1 2 3 3 3 0 CorA-like Mg2+ transporter protein Laminin_II PF06009.10 001109901.2_45725001_2 - 0.018 14.9 5.6 6 6.7 0.6 5.1 4 2 3 7 7 7 0 Laminin Domain II Yuri_gagarin PF15934.3 001109901.2_45725001_2 - 0.025 14.3 0.3 0.025 14.3 0.3 2.5 3 1 0 3 3 1 0 Yuri gagarin TACC PF05010.12 001109901.2_45725001_2 - 0.031 13.9 1.1 5.9 6.5 0.1 3.4 2 1 1 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC) SlyX PF04102.10 001109901.2_45725001_2 - 0.053 14.0 0.1 0.053 14.0 0.1 7.9 8 3 2 10 10 6 0 SlyX DUF3450 PF11932.6 001109901.2_45725001_2 - 0.055 12.6 9.9 0.96 8.6 0.9 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF3450) DUF2730 PF10805.6 001109901.2_45725001_2 - 0.063 13.2 0.1 0.063 13.2 0.1 4.5 4 2 2 6 6 4 0 Protein of unknown function (DUF2730) HSBP1 PF06825.10 001109901.2_45725001_2 - 0.067 13.0 0.2 0.96 9.3 0.0 3.1 4 0 0 4 4 2 0 Heat shock factor binding protein 1 EzrA PF06160.10 001109901.2_45725001_2 - 0.077 11.0 0.0 0.68 7.9 0.0 2.0 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA GSH_synth_ATP PF03917.15 001109901.2_45725001_2 - 0.092 11.4 0.5 0.25 9.9 0.4 1.6 1 1 1 2 2 2 0 Eukaryotic glutathione synthase, ATP binding domain Lebercilin PF15619.4 001109901.2_45725001_2 - 0.093 12.2 15.3 1.1 8.8 2.8 4.0 3 1 1 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease DUF16 PF01519.14 001109901.2_45725001_2 - 0.14 12.6 6.5 1 9.7 0.2 4.3 3 1 1 4 4 4 0 Protein of unknown function DUF16 Fez1 PF06818.13 001109901.2_45725001_2 - 0.15 12.3 9.5 0.2 12.0 1.5 3.3 2 1 1 3 3 3 0 Fez1 Scm3 PF10384.7 001109901.2_45725001_2 - 0.16 11.6 0.0 0.36 10.5 0.0 1.6 1 0 0 1 1 1 0 Centromere protein Scm3 IFT57 PF10498.7 001109901.2_45725001_2 - 0.17 10.7 4.7 2 7.2 0.6 2.8 2 1 1 3 3 3 0 Intra-flagellar transport protein 57 KxDL PF10241.7 001109901.2_45725001_2 - 0.23 11.6 12.1 35 4.6 0.5 6.1 5 1 1 7 7 6 0 Uncharacterized conserved protein DUF4795 PF16043.3 001109901.2_45725001_2 - 0.27 10.7 3.1 11 5.4 0.0 3.7 2 1 0 3 3 3 0 Domain of unknown function (DUF4795) DUF5082 PF16888.3 001109901.2_45725001_2 - 0.32 11.2 5.7 24 5.2 0.1 5.2 4 2 2 6 6 6 0 Domain of unknown function (DUF5082) AAA_13 PF13166.4 001109901.2_45725001_2 - 0.32 9.5 2.3 0.26 9.7 0.4 1.8 2 1 0 2 2 2 0 AAA domain COG2 PF06148.9 001109901.2_45725001_2 - 0.39 10.7 13.2 1 9.3 0.9 4.8 5 1 1 6 6 4 0 COG (conserved oligomeric Golgi) complex component, COG2 Lant_dehydr_C PF14028.4 001109901.2_45725001_2 - 0.4 10.0 6.0 1.2 8.5 0.0 3.1 2 1 1 3 3 3 0 Lantibiotic biosynthesis dehydratase C-term Uso1_p115_C PF04871.11 001109901.2_45725001_2 - 0.44 10.8 11.9 0.3 11.3 0.3 4.5 3 1 3 6 6 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region FPP PF05911.9 001109901.2_45725001_2 - 0.59 8.2 6.9 1.1 7.3 1.1 2.6 2 1 0 2 2 2 0 Filament-like plant protein, long coiled-coil Filament PF00038.19 001109901.2_45725001_2 - 0.74 9.2 12.3 0.22 10.9 0.5 4.1 2 1 3 5 5 5 0 Intermediate filament protein Tmemb_cc2 PF10267.7 001109901.2_45725001_2 - 1 8.3 6.6 0.33 9.9 2.0 2.0 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein OmpH PF03938.12 001109901.2_45725001_2 - 1.3 8.9 3.2 7.9 6.3 0.2 2.8 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) Dynactin_p22 PF07426.9 001109901.2_45725001_2 - 1.6 8.4 5.6 19 4.9 0.1 4.0 4 1 0 4 4 4 0 Dynactin subunit p22 GAS PF13851.4 001109901.2_45725001_2 - 1.7 7.9 12.1 0.17 11.1 0.1 3.9 3 2 0 4 4 4 0 Growth-arrest specific micro-tubule binding Myosin_tail_1 PF01576.17 001109901.2_45725001_2 - 2.2 5.8 8.1 0.28 8.8 2.0 2.1 2 0 0 2 2 2 0 Myosin tail CALCOCO1 PF07888.9 001109901.2_45725001_2 - 2.3 6.6 17.5 0.61 8.5 9.0 3.0 2 1 1 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like Lectin_N PF03954.12 001109901.2_45725001_2 - 2.3 7.8 9.1 2.6 7.6 0.9 4.3 2 2 2 5 5 5 0 Hepatic lectin, N-terminal domain APG6 PF04111.10 001109901.2_45725001_2 - 2.7 7.2 7.0 2.5 7.3 1.3 3.0 2 1 1 3 3 3 0 Autophagy protein Apg6 Fib_alpha PF08702.8 001109901.2_45725001_2 - 5.4 7.1 9.8 6.8 6.7 0.2 5.0 3 2 2 6 6 6 0 Fibrinogen alpha/beta chain family SKA1 PF07160.10 001109901.2_45725001_2 - 5.8 6.6 5.1 6.6 6.4 0.1 3.1 2 1 0 4 4 3 0 Spindle and kinetochore-associated protein 1 DUF4094 PF13334.4 001109901.2_45725001_2 - 6.1 7.2 7.2 24 5.3 0.1 3.8 4 1 0 4 4 3 0 Domain of unknown function (DUF4094) WXG100 PF06013.10 001109901.2_45725001_2 - 6.3 7.0 18.1 0.25 11.5 1.1 5.6 6 2 1 7 7 4 0 Proteins of 100 residues with WXG TPR_MLP1_2 PF07926.10 001109901.2_45725001_2 - 8.5 6.3 21.9 3.5 7.6 4.3 5.3 3 1 1 5 5 5 0 TPR/MLP1/MLP2-like protein Homeobox PF00046.27 001168895.1_40423001_1 - 6.4e-22 77.0 4.7 1.1e-21 76.2 4.7 1.4 1 0 0 1 1 1 1 Homeobox domain PRIMA1 PF16101.3 001168895.1_40423001_2 - 2 8.4 13.3 4.7 7.1 13.3 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 S1 PF00575.21 001107604.2_45729001_3 - 8.9e-67 221.3 8.9 8.4e-12 45.1 0.0 13.3 13 0 0 13 13 13 10 S1 RNA binding domain Suf PF05843.12 001107604.2_45729001_3 - 1.8e-09 37.9 1.3 1.8e-09 37.9 1.3 3.8 2 1 0 3 3 3 2 Suppressor of forked protein (Suf) TPR_14 PF13428.4 001107604.2_45729001_3 - 5.3e-07 29.8 0.9 0.26 12.1 0.0 4.3 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.4 001107604.2_45729001_3 - 1.4e-06 28.6 0.0 0.72 10.3 0.0 3.7 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_15 PF13429.4 001107604.2_45729001_3 - 0.0011 18.2 3.7 0.5 9.4 0.0 3.2 1 1 1 3 3 3 2 Tetratricopeptide repeat NRDE-2 PF08424.8 001107604.2_45729001_3 - 0.003 16.6 8.6 0.53 9.2 0.6 3.9 2 1 2 4 4 4 2 NRDE-2, necessary for RNA interference TPR_12 PF13424.4 001107604.2_45729001_3 - 0.0076 16.4 1.2 1.8 8.8 0.1 4.1 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.4 001107604.2_45729001_3 - 0.0083 16.1 0.4 11 6.5 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.4 001107604.2_45729001_3 - 0.014 15.3 0.0 0.49 10.4 0.0 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.4 001107604.2_45729001_3 - 0.023 15.3 0.1 30 5.3 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.4 001107604.2_45729001_3 - 0.031 14.8 2.2 0.52 10.9 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1344 PF07076.9 001107604.2_45729001_3 - 0.047 13.5 0.2 0.14 11.9 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1344) TPR_2 PF07719.15 001107604.2_45729001_3 - 0.047 13.7 2.8 5.6 7.2 0.1 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2110 PF09883.7 001107604.2_45729001_3 - 0.1 12.1 0.0 0.66 9.4 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2110) La PF05383.15 001107361.1_45729001_2 - 4.6e-14 52.1 0.1 1e-13 51.0 0.1 1.6 1 0 0 1 1 1 1 La domain NDUF_B8 PF05821.9 001144864.1_39722001_1 - 3.3e-77 258.2 6.4 3.7e-77 258.1 6.4 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) RINGv PF12906.5 001106372.2_45723001_2 - 2.1e-14 53.2 10.6 3.8e-14 52.4 10.6 1.4 1 0 0 1 1 1 1 RING-variant domain DUF2517 PF10725.7 001106372.2_45723001_2 - 0.0032 17.1 0.1 0.0076 15.9 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2517) zf-RING_2 PF13639.4 001106372.2_45723001_2 - 0.0061 16.7 6.4 0.014 15.5 6.4 1.6 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.6 001106372.2_45723001_2 - 0.033 14.2 5.0 0.069 13.2 5.0 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.4 001106372.2_45723001_2 - 0.62 9.7 5.9 1.3 8.6 5.9 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain PHD PF00628.27 001106372.2_45723001_2 - 1.6 8.6 8.4 3.6 7.4 8.4 1.7 1 0 0 1 1 1 0 PHD-finger EF-hand_8 PF13833.4 001130243.1_49821001_1 - 8.2e-28 95.8 16.6 3.8e-15 55.3 0.4 3.5 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_7 PF13499.4 001130243.1_49821001_1 - 4.1e-27 94.3 10.0 6.4e-16 58.5 6.4 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 001130243.1_49821001_1 - 9.8e-26 87.2 24.4 3.2e-08 32.4 1.0 4.8 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.4 001130243.1_49821001_1 - 7.5e-21 72.1 15.5 1.1e-07 31.1 0.4 5.1 3 1 2 5 5 5 4 EF-hand domain EF-hand_5 PF13202.4 001130243.1_49821001_1 - 3e-15 54.8 20.4 1.6e-06 27.2 0.3 5.0 4 1 1 5 5 5 3 EF hand EF-hand_9 PF14658.4 001130243.1_49821001_1 - 6.4e-13 48.7 1.1 3.7e-06 27.0 0.3 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 001130243.1_49821001_1 - 1.3e-06 28.2 7.4 0.013 15.3 0.0 3.1 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 001130243.1_49821001_1 - 3.3e-05 24.0 1.7 0.0014 18.8 0.5 2.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.11 001130243.1_49821001_1 - 0.0021 17.9 0.1 1.3 8.8 0.0 2.3 1 1 0 2 2 2 2 Tellurite resistance protein TerB DUF1707 PF08044.9 001130243.1_49821001_1 - 0.0057 16.6 0.3 1.7 8.6 0.1 3.1 3 1 0 3 3 3 1 Domain of unknown function (DUF1707) UPF0154 PF03672.11 001130243.1_49821001_1 - 0.0073 16.2 0.0 2.1 8.3 0.0 2.3 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0154) EF-hand_10 PF14788.4 001130243.1_49821001_1 - 0.029 14.1 4.2 0.099 12.4 0.9 2.9 2 1 1 3 3 3 0 EF hand Dak2 PF02734.15 001130243.1_49821001_1 - 0.049 13.4 0.0 0.6 9.9 0.0 2.0 2 0 0 2 2 2 0 DAK2 domain EMG1 PF03587.12 001130243.1_49821001_1 - 0.091 12.3 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 EMG1/NEP1 methyltransferase DUF1456 PF07308.11 001130243.1_49821001_1 - 0.19 12.0 4.4 2.7 8.3 0.2 3.2 2 1 2 4 4 4 0 Protein of unknown function (DUF1456) RNA_pol_Rpb4 PF03874.14 001130243.1_49821001_1 - 0.7 10.1 3.5 18 5.5 0.1 2.5 3 0 0 3 3 2 0 RNA polymerase Rpb4 Vps5 PF09325.8 001106518.1_45725001_2 - 9e-18 64.5 12.3 1.2e-15 57.6 12.3 2.1 1 1 0 1 1 1 1 Vps5 C terminal like BAR PF03114.16 001106518.1_45725001_2 - 0.0026 17.3 9.8 0.0036 16.9 9.8 1.2 1 0 0 1 1 1 1 BAR domain PX PF00787.22 001106518.1_45725001_3 - 1.8e-11 43.9 0.0 3.5e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 PX domain ABC_tran PF00005.25 001123069.1_49825001_1 - 4.8e-44 150.1 12.0 1.6e-22 80.4 0.0 4.1 5 0 0 5 5 3 2 ABC transporter AAA_21 PF13304.4 001123069.1_49825001_1 - 1.5e-14 54.4 4.0 0.0017 18.1 0.0 4.7 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 001123069.1_49825001_1 - 1.2e-06 28.0 0.0 0.0039 16.7 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain NACHT PF05729.10 001123069.1_49825001_1 - 9.2e-06 25.5 0.0 0.05 13.4 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_18 PF13238.4 001123069.1_49825001_1 - 1.4e-05 25.5 7.6 0.0087 16.4 0.0 4.8 3 2 1 5 5 3 1 AAA domain AAA_24 PF13479.4 001123069.1_49825001_1 - 1.4e-05 24.7 0.0 0.22 11.1 0.0 3.1 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.14 001123069.1_49825001_1 - 1.5e-05 24.8 2.9 0.02 14.6 0.0 3.0 3 0 0 3 3 2 2 Protein of unknown function, DUF258 ABC_tran_Xtn PF12848.5 001123069.1_49825001_1 - 1.9e-05 24.4 16.4 1.9e-05 24.4 16.4 5.2 4 1 0 4 4 3 1 ABC transporter AAA_16 PF13191.4 001123069.1_49825001_1 - 2.5e-05 24.6 2.7 0.14 12.4 0.1 3.0 3 0 0 3 3 2 2 AAA ATPase domain AAA_14 PF13173.4 001123069.1_49825001_1 - 2.9e-05 24.0 0.1 0.14 12.0 0.0 3.3 3 0 0 3 3 2 2 AAA domain AAA PF00004.27 001123069.1_49825001_1 - 3.4e-05 24.2 0.6 0.12 12.6 0.0 3.3 3 1 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.21 001123069.1_49825001_1 - 0.00013 21.9 0.2 0.059 13.3 0.0 3.1 3 0 0 3 3 3 1 50S ribosome-binding GTPase AAA_5 PF07728.12 001123069.1_49825001_1 - 0.00019 21.3 0.5 0.92 9.4 0.1 3.1 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) SMC_N PF02463.17 001123069.1_49825001_1 - 0.00021 20.7 26.3 0.00029 20.2 0.0 4.3 2 2 1 3 3 2 2 RecF/RecN/SMC N terminal domain RNA_helicase PF00910.20 001123069.1_49825001_1 - 0.00024 21.3 0.0 1.2 9.4 0.0 2.9 2 0 0 2 2 2 2 RNA helicase AAA_28 PF13521.4 001123069.1_49825001_1 - 0.00072 19.7 7.2 0.095 12.8 0.1 3.3 3 0 0 3 3 2 2 AAA domain AAA_23 PF13476.4 001123069.1_49825001_1 - 0.00075 19.9 0.0 0.00075 19.9 0.0 5.5 5 1 1 6 6 3 2 AAA domain AAA_22 PF13401.4 001123069.1_49825001_1 - 0.00096 19.3 5.7 0.31 11.2 0.2 3.6 3 1 0 3 3 3 2 AAA domain AAA_25 PF13481.4 001123069.1_49825001_1 - 0.0016 17.9 0.8 0.46 9.9 0.0 3.1 2 2 0 2 2 2 1 AAA domain Roc PF08477.11 001123069.1_49825001_1 - 0.0016 18.5 0.0 2.3 8.4 0.0 3.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase NTPase_1 PF03266.13 001123069.1_49825001_1 - 0.0018 18.1 0.7 1.8 8.3 0.1 3.1 3 0 0 3 3 3 2 NTPase cobW PF02492.17 001123069.1_49825001_1 - 0.0024 17.4 0.1 0.31 10.5 0.0 2.7 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.20 001123069.1_49825001_1 - 0.011 15.2 0.0 1.5 8.3 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain NB-ARC PF00931.20 001123069.1_49825001_1 - 0.021 13.7 1.5 1.3 7.8 0.0 3.0 3 0 0 3 3 3 0 NB-ARC domain IstB_IS21 PF01695.15 001123069.1_49825001_1 - 0.025 14.2 0.0 3.9 7.1 0.0 2.8 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_33 PF13671.4 001123069.1_49825001_1 - 0.043 13.8 7.1 1.3 9.0 0.0 3.5 4 0 0 4 4 2 0 AAA domain PduV-EutP PF10662.7 001123069.1_49825001_1 - 0.069 12.8 0.1 8.7 5.9 0.0 3.2 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation ATP-synt_ab PF00006.23 001123069.1_49825001_1 - 0.11 11.9 0.0 3.7 7.0 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain ATPase_2 PF01637.16 001123069.1_49825001_1 - 1.4 8.7 0.0 1.4 8.7 0.0 3.9 4 0 0 4 4 3 0 ATPase domain predominantly from Archaea LSM PF01423.20 001130710.1_26225001_2 - 6.4e-19 67.3 0.6 1e-18 66.7 0.6 1.3 1 0 0 1 1 1 1 LSM domain DDA1 PF10172.7 001131649.1_43529001_1 - 1e-28 99.3 0.1 1.6e-28 98.6 0.1 1.3 1 0 0 1 1 1 1 Det1 complexing ubiquitin ligase zf-C3HC4_4 PF15227.4 001108276.1_45725001_2 - 1.3e-12 47.6 10.8 1.3e-12 47.6 10.8 2.6 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001108276.1_45725001_2 - 6.7e-11 41.7 8.5 6.7e-11 41.7 8.5 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001108276.1_45725001_2 - 3.3e-10 39.7 8.2 1.5e-09 37.6 8.2 2.2 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 001108276.1_45725001_2 - 6.3e-09 35.4 10.2 6.3e-09 35.4 10.2 2.6 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001108276.1_45725001_2 - 6.7e-08 32.4 0.1 6.7e-08 32.4 0.1 3.2 3 0 0 3 3 3 1 B-box zinc finger zf-C3HC4_3 PF13920.4 001108276.1_45725001_2 - 1.3e-06 28.0 7.8 1.3e-06 28.0 7.8 3.0 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001108276.1_45725001_2 - 1.4e-06 28.3 10.4 1.4e-06 28.3 10.4 3.3 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.4 001108276.1_45725001_2 - 8e-05 22.4 9.0 8e-05 22.4 9.0 2.8 3 0 0 3 3 2 1 zinc-RING finger domain zf-RING_6 PF14835.4 001108276.1_45725001_2 - 0.0011 18.7 2.4 0.0011 18.7 2.4 2.2 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.3 001108276.1_45725001_2 - 0.016 15.2 4.4 0.056 13.5 4.4 1.9 1 0 0 1 1 1 0 zinc RING finger of MSL2 U-box PF04564.13 001108276.1_45725001_2 - 0.079 13.0 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 U-box domain PRY PF13765.4 001108276.1_45725001_3 - 4.4e-23 80.5 0.1 9e-23 79.5 0.1 1.6 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 001108276.1_45725001_3 - 3.2e-13 49.7 0.2 7.6e-13 48.5 0.0 1.7 2 0 0 2 2 2 1 SPRY domain EF-hand_7 PF13499.4 001123125.1_49822001_1 - 2.3e-27 95.1 4.3 3e-18 65.9 0.1 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.30 001123125.1_49822001_1 - 7.1e-26 87.7 5.1 2.8e-07 29.5 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 001123125.1_49822001_1 - 5.6e-22 75.6 3.0 5.8e-06 25.7 0.1 4.4 4 1 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.4 001123125.1_49822001_1 - 4.2e-21 73.3 6.0 1.9e-07 30.2 0.1 4.4 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.4 001123125.1_49822001_1 - 1.1e-16 60.2 7.9 1.5e-08 34.1 0.1 3.6 3 2 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 001123125.1_49822001_1 - 2.3e-07 31.0 0.3 0.0029 17.8 0.1 3.3 2 2 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 001123125.1_49822001_1 - 4.8e-07 29.6 1.0 0.096 12.5 0.1 3.3 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.4 001123125.1_49822001_1 - 0.00094 18.9 0.2 1.8 8.3 0.0 3.0 3 0 0 3 3 3 2 EF hand EF-hand_9 PF14658.4 001123125.1_49822001_1 - 0.0021 18.2 0.1 3 8.1 0.0 3.2 2 1 1 3 3 3 1 EF-hand domain Cortexin PF11057.6 001048252.2_26224001_2 - 1.8e-39 133.3 0.1 3.5e-39 132.4 0.1 1.5 1 0 0 1 1 1 1 Cortexin of kidney TGF_beta PF00019.18 001109671.1_45723001_2 - 9.1e-33 113.2 0.5 1.9e-32 112.1 0.5 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.16 001109671.1_45723001_2 - 8.5e-07 28.8 0.0 9.8e-05 22.1 0.0 2.1 2 0 0 2 2 2 2 TGF-beta propeptide NACHT PF05729.10 001114351.1_29628001_2 - 1.1e-49 168.4 0.2 3.3e-49 166.8 0.0 1.9 2 0 0 2 2 2 1 NACHT domain PYRIN PF02758.14 001114351.1_29628001_2 - 4e-21 74.9 0.1 1.1e-20 73.5 0.1 1.8 1 0 0 1 1 1 1 PAAD/DAPIN/Pyrin domain LRR_6 PF13516.4 001114351.1_29628001_2 - 1.3e-19 68.4 25.2 0.00015 21.4 0.1 7.4 7 0 0 7 7 7 5 Leucine Rich repeat FISNA PF14484.4 001114351.1_29628001_2 - 1.9e-16 59.9 0.1 3.7e-16 59.0 0.1 1.5 1 0 0 1 1 1 1 Fish-specific NACHT associated domain LRR_4 PF12799.5 001114351.1_29628001_2 - 7.1e-06 26.1 26.0 0.078 13.3 1.0 6.5 2 1 6 8 8 8 6 Leucine Rich repeats (2 copies) NB-ARC PF00931.20 001114351.1_29628001_2 - 0.041 12.8 0.0 0.085 11.7 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain LRR_1 PF00560.31 001114351.1_29628001_2 - 0.18 12.3 28.9 19 6.1 0.0 9.0 8 0 0 8 8 8 0 Leucine Rich Repeat LRR_8 PF13855.4 001114351.1_29628001_2 - 0.42 10.3 19.2 2.4 7.9 0.7 5.6 5 1 0 5 5 5 0 Leucine rich repeat PET PF06297.12 199396.1_45729001_2 - 8.2e-38 128.5 0.7 1.6e-37 127.5 0.7 1.5 1 0 0 1 1 1 1 PET Domain LIM PF00412.20 199396.1_45729001_2 - 2.3e-23 82.0 39.0 6.8e-09 35.7 11.6 3.8 3 1 0 3 3 3 3 LIM domain Vasculin PF15337.4 199396.1_45729001_2 - 0.033 14.9 1.6 0.048 14.4 0.0 2.0 2 0 0 2 2 2 0 Vascular protein family Vasculin-like 1 Cpn60_TCP1 PF00118.22 001133614.1_43525001_3 - 1.4e-84 284.3 18.4 3.4e-84 283.1 18.4 1.5 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family 4HB_MCP_1 PF12729.5 001133614.1_43525001_3 - 1.2 8.5 4.5 2.9 7.3 1.3 2.2 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction Peptidase_M14 PF00246.22 053617.2_45723001_3 - 4.8e-90 302.1 0.3 6.3e-90 301.7 0.3 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.14 053617.2_45723001_3 - 3.8e-15 55.9 0.8 8.7e-15 54.7 0.8 1.7 1 0 0 1 1 1 1 Carboxypeptidase activation peptide Tropomyosin PF00261.18 001105688.1_37923001_1 - 2e-101 338.2 83.2 2.9e-97 324.6 59.8 2.0 1 1 1 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.5 001105688.1_37923001_1 - 3.5e-41 140.6 70.2 4.3e-37 127.3 39.8 3.0 2 1 0 2 2 2 2 Tropomyosin like CLZ PF16526.3 001105688.1_37923001_1 - 5e-06 26.6 47.1 5.6e-05 23.3 10.5 4.8 1 1 1 4 4 4 3 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Laminin_II PF06009.10 001105688.1_37923001_1 - 9.9e-06 25.5 36.8 0.0001 22.2 6.5 4.0 1 1 3 4 4 4 4 Laminin Domain II TMF_DNA_bd PF12329.6 001105688.1_37923001_1 - 0.0013 18.5 9.6 0.0013 18.5 9.6 6.3 1 1 6 7 7 7 3 TATA element modulatory factor 1 DNA binding IncA PF04156.12 001105688.1_37923001_1 - 0.0021 17.8 59.9 0.0023 17.6 24.0 2.9 1 1 2 3 3 3 1 IncA protein CENP-F_leu_zip PF10473.7 001105688.1_37923001_1 - 0.013 15.4 28.9 0.013 15.4 28.9 2.3 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.4 001105688.1_37923001_1 - 0.015 13.9 46.9 0.05 12.1 29.3 2.1 1 1 1 2 2 2 0 AAA domain Laminin_I PF06008.12 001105688.1_37923001_1 - 0.024 14.2 51.9 0.059 12.9 15.6 3.2 1 1 2 3 3 3 0 Laminin Domain I XhlA PF10779.7 001105688.1_37923001_1 - 0.026 14.6 2.4 0.026 14.6 2.4 6.5 2 2 5 7 7 7 0 Haemolysin XhlA DUF1664 PF07889.10 001105688.1_37923001_1 - 0.026 14.4 29.0 0.093 12.6 4.5 3.9 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) ERM PF00769.17 001105688.1_37923001_1 - 0.043 13.5 69.4 0.41 10.3 23.1 3.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF745 PF05335.11 001105688.1_37923001_1 - 0.044 13.4 48.9 0.31 10.6 8.8 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF745) ATG16 PF08614.9 001105688.1_37923001_1 - 0.09 12.8 60.2 0.14 12.2 21.3 3.2 1 1 1 2 2 1 0 Autophagy protein 16 (ATG16) Golgin_A5 PF09787.7 001105688.1_37923001_1 - 0.14 11.4 52.8 1.2 8.4 20.3 2.7 1 1 2 3 3 3 0 Golgin subfamily A member 5 MscS_porin PF12795.5 001105688.1_37923001_1 - 0.15 11.4 48.1 5.1 6.4 28.8 3.2 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Alanine_zipper PF11839.6 001105688.1_37923001_1 - 0.17 12.0 47.9 0.072 13.2 2.1 4.6 1 1 3 4 4 4 0 Alanine-zipper, major outer membrane lipoprotein ADIP PF11559.6 001105688.1_37923001_1 - 0.24 11.4 48.5 2.2 8.2 5.9 4.1 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding DUF16 PF01519.14 001105688.1_37923001_1 - 0.72 10.2 37.9 0.61 10.5 0.3 4.3 1 1 3 4 4 4 0 Protein of unknown function DUF16 Reo_sigmaC PF04582.10 001105688.1_37923001_1 - 0.94 8.7 9.3 1.5 8.0 0.9 2.2 2 0 0 2 2 2 0 Reovirus sigma C capsid protein DUF3584 PF12128.6 001105688.1_37923001_1 - 1.6 6.0 56.7 1.2 6.5 24.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) MAD PF05557.11 001105688.1_37923001_1 - 1.9 6.6 57.7 4.7 5.3 27.8 2.0 1 1 1 2 2 2 0 Mitotic checkpoint protein GAS PF13851.4 001105688.1_37923001_1 - 2.2 7.4 59.8 1.2 8.4 15.4 2.9 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Fmp27_WPPW PF10359.7 001105688.1_37923001_1 - 2.6 6.7 36.8 0.57 8.8 9.3 2.7 1 1 2 3 3 3 0 RNA pol II promoter Fmp27 protein domain NPV_P10 PF05531.10 001105688.1_37923001_1 - 2.8 8.4 18.2 22 5.5 0.5 4.5 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein SlyX PF04102.10 001105688.1_37923001_1 - 3.5 8.2 43.8 0.85 10.1 0.4 5.5 1 1 5 6 6 6 0 SlyX APG6 PF04111.10 001105688.1_37923001_1 - 3.5 6.8 63.2 7.8 5.7 24.5 3.1 1 1 2 3 3 3 0 Autophagy protein Apg6 EzrA PF06160.10 001105688.1_37923001_1 - 3.9 5.4 53.6 0.26 9.3 7.1 3.1 1 1 2 3 3 3 0 Septation ring formation regulator, EzrA Exonuc_VII_L PF02601.13 001105688.1_37923001_1 - 4 6.8 35.3 19 4.5 12.9 2.3 1 1 1 2 2 2 0 Exonuclease VII, large subunit Fib_alpha PF08702.8 001105688.1_37923001_1 - 4.8 7.2 32.5 0.19 11.8 6.8 3.4 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family SNARE PF05739.17 001105688.1_37923001_1 - 5.1 7.0 11.2 2.3 8.2 0.1 4.4 5 0 0 5 5 4 0 SNARE domain Lebercilin PF15619.4 001105688.1_37923001_1 - 6.4 6.2 61.8 18 4.8 25.6 3.2 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DUF4472 PF14739.4 001105688.1_37923001_1 - 7 7.3 49.7 0.84 10.3 6.1 4.6 1 1 3 4 4 3 0 Domain of unknown function (DUF4472) HOOK PF05622.10 001105688.1_37923001_1 - 7.5 4.4 56.8 0.11 10.5 16.0 2.1 1 1 1 2 2 2 0 HOOK protein COG2 PF06148.9 001105688.1_37923001_1 - 7.5 6.5 29.6 0.14 12.1 2.5 4.1 1 1 4 5 5 5 0 COG (conserved oligomeric Golgi) complex component, COG2 tRNA-synt_1e PF01406.17 001106319.1_45726001_3 - 2.6e-127 424.2 0.0 2.6e-127 424.2 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.9 001106319.1_45726001_3 - 4.7e-07 28.8 0.5 0.00061 18.6 0.1 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.20 001106319.1_45726001_3 - 0.0029 15.8 0.9 0.0058 14.8 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) DUF2175 PF09943.7 001106319.1_45726001_3 - 0.1 12.8 1.4 1 9.5 2.4 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) tRNA-synt_1c PF00749.19 001106319.1_45726001_3 - 0.14 10.8 2.6 1.9 7.2 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain POX PF07526.9 001106319.1_45726001_3 - 0.74 10.3 5.8 2.6 8.5 5.8 1.8 1 0 0 1 1 1 0 Associated with HOX AAA_15 PF13175.4 001106319.1_45726001_3 - 2.9 7.3 12.6 0.43 10.0 4.2 2.4 3 0 0 3 3 3 0 AAA ATPase domain Ras PF00071.20 001106950.2_45727001_3 - 2.1e-54 183.3 0.0 3.1e-54 182.8 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001106950.2_45727001_3 - 7.3e-19 68.0 0.0 1.1e-18 67.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001106950.2_45727001_3 - 1.9e-08 33.8 0.0 3.1e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 001106950.2_45727001_3 - 8.8e-05 22.3 0.3 0.049 13.4 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001106950.2_45727001_3 - 0.0021 17.5 0.0 0.0052 16.2 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001106950.2_45727001_3 - 0.0089 16.0 0.0 0.013 15.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase IFT20 PF14931.4 001105815.1_45723001_2 - 1.6e-49 166.9 9.7 1.6e-49 166.9 9.7 1.6 2 0 0 2 2 2 1 Intraflagellar transport complex B, subunit 20 OAD_gamma PF04277.11 001105815.1_45723001_2 - 0.37 11.3 4.5 0.12 12.9 0.8 1.9 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF3135 PF11333.6 001105815.1_45723001_2 - 1.4 9.1 7.3 4 7.6 3.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3135) Hydin_ADK PF17213.1 001105815.1_45723001_2 - 4.2 7.5 8.5 1.4 9.0 5.0 1.8 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain ETC_C1_NDUFA5 PF04716.12 001131860.1_43525001_1 - 4.7e-26 90.3 0.5 8.3e-26 89.5 0.5 1.4 1 0 0 1 1 1 1 ETC complex I subunit conserved region Clat_adaptor_s PF01217.18 001115039.1_45723001_2 - 1.6e-51 173.8 2.9 2.1e-51 173.5 2.9 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain IL4Ra_N PF09238.8 133380.2_45728001_1 - 1.6e-36 124.4 1.4 3.8e-36 123.2 1.4 1.7 1 0 0 1 1 1 1 Interleukin-4 receptor alpha chain, N-terminal fn3 PF00041.19 133380.2_45728001_1 - 0.0035 17.5 0.1 0.0094 16.1 0.1 1.7 1 0 0 1 1 1 1 Fibronectin type III domain F5_F8_type_C PF00754.23 001131002.1_45722001_2 - 3.9e-05 23.6 0.0 6e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain ANAPC10 PF03256.14 001131002.1_45722001_2 - 0.0058 16.2 0.0 0.0074 15.8 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) XRCC1_N PF01834.14 001131002.1_45722001_2 - 0.0063 16.5 0.0 0.0095 15.9 0.0 1.2 1 0 0 1 1 1 1 XRCC1 N terminal domain GTP_EFTU PF00009.25 001132075.1_43527001_3 - 7.6e-65 218.0 0.0 1e-64 217.5 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.16 001132075.1_43527001_3 - 3.1e-34 117.2 0.1 9.3e-34 115.7 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.22 001132075.1_43527001_3 - 9.4e-23 79.9 0.0 2.1e-22 78.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.4 001132075.1_43527001_3 - 2.5e-13 49.8 0.0 5.2e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.23 001132075.1_43527001_3 - 3.3e-13 49.7 0.2 1.6e-12 47.5 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 001132075.1_43527001_3 - 1.4e-05 25.1 0.1 3.3e-05 23.8 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Tim17 PF02466.17 001160374.1_39721001_1 - 7.4e-07 29.3 2.4 1.1e-06 28.7 2.4 1.4 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family 2OG-FeII_Oxy_2 PF13532.4 001127450.1_45722001_3 - 1.9e-12 47.7 0.0 4.6e-11 43.2 0.0 2.0 1 1 1 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.18 001127450.1_45722001_3 - 0.00048 20.4 0.0 0.00093 19.5 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily GKAP PF03359.11 001135802.1_45726001_2 - 8.2e-32 111.0 8.0 8.2e-32 111.0 8.0 2.0 1 1 0 1 1 1 1 Guanylate-kinase-associated protein (GKAP) protein Cyclin_N PF00134.21 001100472.1_45727001_1 - 1.9e-12 46.9 4.5 7.8e-12 45.0 0.8 2.4 3 0 0 3 3 3 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.3 001100472.1_45727001_1 - 3.6e-06 27.2 0.1 8.7e-06 26.0 0.1 1.7 1 0 0 1 1 1 1 Cyclin C-terminal domain TFIIB PF00382.17 001100472.1_45727001_1 - 0.41 10.6 1.9 0.68 9.9 0.0 2.2 3 0 0 3 3 3 0 Transcription factor TFIIB repeat Pribosyltran PF00156.25 001106127.1_45723001_2 - 3.4e-24 85.0 0.1 4.9e-24 84.5 0.1 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.4 001106127.1_45723001_2 - 0.16 11.3 0.0 0.31 10.3 0.0 1.5 2 0 0 2 2 2 0 Uracil phosphoribosyltransferase HSP70 PF00012.18 001123128.1_49826001_3 - 2.1e-260 865.0 4.7 2.4e-260 864.8 4.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 001123128.1_49826001_3 - 1.1e-16 60.5 0.2 5.4e-15 54.9 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.4 001123128.1_49826001_3 - 0.0046 17.2 0.3 8.1 6.8 0.0 3.3 3 0 0 3 3 3 2 Cell division protein FtsA FGGY_C PF02782.14 001123128.1_49826001_3 - 0.0062 16.2 0.0 0.013 15.1 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Radial_spoke_3 PF06098.9 001123128.1_49826001_3 - 0.67 9.1 7.5 0.088 11.9 3.0 1.7 2 0 0 2 2 2 0 Radial spoke protein 3 SdpI PF13630.4 001025122.2_45723001_3 - 0.13 12.3 0.4 0.13 12.3 0.4 2.2 2 0 0 2 2 2 0 SdpI/YhfL protein family DUF3961 PF13106.4 001025122.2_45723001_3 - 1.5 8.4 3.2 3.3 7.4 1.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3961) Aldedh PF00171.20 031731.2_45726001_1 - 9.4e-89 297.9 0.0 1.3e-88 297.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Pam17 PF08566.8 031731.2_45726001_1 - 0.12 12.1 0.1 2.2 8.0 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial import protein Pam17 NADH_oxidored PF08040.9 001076782.2_39721001_3 - 6.6e-37 124.9 0.2 9.8e-37 124.3 0.2 1.3 1 0 0 1 1 1 1 MNLL subunit Tropomodulin PF03250.12 001133199.1_43529001_2 - 5.8e-10 39.2 0.3 8.1e-10 38.8 0.3 1.1 1 0 0 1 1 1 1 Tropomodulin YL1 PF05764.11 001133199.1_43529001_3 - 1.3e-52 179.3 14.6 1.9e-52 178.7 14.6 1.3 1 0 0 1 1 1 1 YL1 nuclear protein Tropomodulin PF03250.12 001133199.1_43529001_3 - 3.7e-41 140.4 0.4 7.8e-41 139.3 0.4 1.5 1 0 0 1 1 1 1 Tropomodulin YL1_C PF08265.9 001133199.1_43529001_3 - 7.7e-12 44.6 0.6 1.5e-11 43.7 0.6 1.5 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain GTSE1_N PF15259.4 001130500.1_45726001_1 - 4.2e-61 205.2 0.6 8.2e-61 204.3 0.6 1.5 1 0 0 1 1 1 1 G-2 and S-phase expressed 1 zf-C2H2 PF00096.24 001142578.1_26228001_1 - 0.069 13.5 4.6 1.8 9.1 0.3 3.3 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001142578.1_26228001_2 - 7.1e-152 487.6 158.7 1.5e-08 34.5 0.8 23.7 23 0 0 23 23 23 23 Zinc-finger double domain zf-C2H2 PF00096.24 001142578.1_26228001_2 - 1e-85 277.6 148.5 1.6e-06 28.1 0.6 21.8 21 0 0 21 21 21 21 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001142578.1_26228001_2 - 1.2e-42 140.7 164.9 0.0092 16.6 0.4 22.1 22 0 0 22 22 22 18 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001142578.1_26228001_2 - 9.1e-41 137.0 127.9 0.002 17.9 0.7 21.7 21 0 0 21 21 21 19 C2H2-type zinc finger KRAB PF01352.25 001142578.1_26228001_2 - 6.5e-26 89.6 0.1 1.1e-25 88.9 0.1 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_jaz PF12171.6 001142578.1_26228001_2 - 1.4e-22 79.3 95.5 0.014 15.6 0.2 20.9 21 0 0 21 21 21 11 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 001142578.1_26228001_2 - 2.9e-20 72.0 103.1 0.0096 15.9 3.1 14.3 7 4 11 18 18 18 18 Zinc ribbon domain zinc_ribbon_15 PF17032.3 001142578.1_26228001_2 - 0.0014 19.2 83.3 0.45 11.1 1.4 10.9 2 2 12 14 14 14 8 zinc-ribbon family DUF3268 PF11672.6 001142578.1_26228001_2 - 5.5 7.2 48.4 27 5.0 0.5 10.0 5 3 1 10 10 10 0 zinc-finger-containing domain zf-C2H2 PF00096.24 001142578.1_26228001_3 - 0.0034 17.6 6.7 0.14 12.6 0.3 3.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001142578.1_26228001_3 - 0.019 15.3 10.6 1.4 9.4 0.2 3.7 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_8 PF15909.3 001142578.1_26228001_3 - 0.59 10.3 3.1 1.4 9.1 3.1 1.6 1 0 0 1 1 1 0 C2H2-type zinc ribbon Zn-ribbon_8 PF09723.8 001142578.1_26228001_3 - 0.8 9.7 4.1 1.9 8.6 4.1 1.6 1 0 0 1 1 1 0 Zinc ribbon domain RNA_pol_Rpb1_2 PF00623.18 001142578.1_26228001_3 - 0.98 9.5 8.9 33 4.5 0.0 5.7 6 1 0 7 7 7 0 RNA polymerase Rpb1, domain 2 zf-C2H2_4 PF13894.4 001142578.1_26228001_3 - 4.6 8.2 13.8 4.2 8.3 0.3 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001142578.1_26228001_3 - 4.7 7.1 5.9 1.3 9.0 0.9 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger Pkinase PF00069.23 001168677.1_29629001_3 - 9.3e-72 241.4 0.0 1.3e-71 240.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001168677.1_29629001_3 - 8e-53 179.2 0.0 1.1e-52 178.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Mst1_SARAH PF11629.6 001168677.1_29629001_3 - 3.1e-24 84.7 3.4 6e-24 83.7 3.4 1.5 1 0 0 1 1 1 1 C terminal SARAH domain of Mst1 PRY PF13765.4 001134974.1_45725001_1 - 2.1e-22 78.3 0.3 1.4e-21 75.7 0.3 2.2 2 0 0 2 2 2 1 SPRY-associated domain SPRY PF00622.26 001134974.1_45725001_1 - 2.9e-21 75.7 0.1 5.6e-21 74.8 0.1 1.5 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.22 001134974.1_45725001_1 - 1.4e-11 44.2 0.6 1.4e-11 44.2 0.6 3.3 3 0 0 3 3 2 1 B-box zinc finger zf-C3HC4_4 PF15227.4 001134974.1_45725001_1 - 8.6e-10 38.5 15.1 8.6e-10 38.5 15.1 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001134974.1_45725001_1 - 2.5e-08 33.5 13.4 7.8e-08 31.9 13.4 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001134974.1_45725001_1 - 6.1e-07 29.2 7.6 6.1e-07 29.2 7.6 3.4 3 1 1 4 4 4 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 001134974.1_45725001_1 - 2.2e-05 24.1 12.5 2.2e-05 24.1 12.5 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001134974.1_45725001_1 - 9.5e-05 22.0 15.9 0.00027 20.6 14.6 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001134974.1_45725001_1 - 0.00026 21.0 14.1 0.00026 21.0 14.1 2.7 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.4 001134974.1_45725001_1 - 0.0036 17.1 12.4 0.0036 17.1 12.4 3.1 2 1 0 2 2 2 1 zinc-RING finger domain zf-RING_4 PF14570.4 001134974.1_45725001_1 - 0.016 14.8 10.4 0.019 14.5 7.6 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Baculo_IE-1 PF05290.9 001134974.1_45725001_1 - 0.67 9.8 11.8 0.04 13.7 5.6 2.2 3 0 0 3 3 3 0 Baculovirus immediate-early protein (IE-0) AP3D1 PF06375.9 001134974.1_45725001_3 - 0.22 11.7 8.5 0.33 11.1 8.5 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 zf-CHCC PF10276.7 001130134.1_39721001_1 - 5.1e-18 64.7 0.7 8.2e-18 64.1 0.7 1.4 1 0 0 1 1 1 1 Zinc-finger domain Thiolase_C PF02803.16 001130134.1_39721001_1 - 0.022 14.3 0.0 0.041 13.4 0.0 1.3 1 0 0 1 1 1 0 Thiolase, C-terminal domain KH_1 PF00013.27 001133294.1_43526001_2 - 1.8e-42 142.8 13.9 1.1e-19 69.9 1.9 3.3 3 0 0 3 3 3 3 KH domain ROKNT PF08067.9 001133294.1_43526001_2 - 3.1e-26 91.2 9.8 5e-26 90.6 9.8 1.3 1 0 0 1 1 1 1 ROKNT (NUC014) domain KH_2 PF07650.15 001133294.1_43526001_2 - 5.2e-13 48.5 6.9 0.0015 18.2 0.5 3.8 3 1 1 4 4 4 3 KH domain KH_4 PF13083.4 001133294.1_43526001_2 - 9.8e-08 31.6 5.2 1.2e-05 24.9 0.0 3.1 3 0 0 3 3 3 2 KH domain KH_5 PF13184.4 001133294.1_43526001_2 - 0.00021 21.2 3.0 0.58 10.2 0.1 3.4 3 0 0 3 3 3 2 NusA-like KH domain MOEP19 PF16005.3 001133294.1_43526001_2 - 0.11 12.4 0.0 3 7.8 0.0 2.2 2 0 0 2 2 2 0 KH-like RNA-binding domain DJ-1_PfpI PF01965.22 001133294.1_43526001_2 - 0.16 11.6 0.0 0.34 10.6 0.0 1.4 1 0 0 1 1 1 0 DJ-1/PfpI family CATSPERD PF15020.4 001134984.1_45725001_3 - 0 1055.7 7.5 0 1055.5 7.5 1.0 1 0 0 1 1 1 1 Cation channel sperm-associated protein subunit delta CPSase_L_D2 PF02786.15 001134984.1_45725001_3 - 0.043 13.2 0.0 2.8 7.2 0.0 2.9 3 0 0 3 3 3 0 Carbamoyl-phosphate synthase L chain, ATP binding domain CC2-LZ PF16516.3 001108826.1_45726001_3 - 3.5e-07 30.4 21.3 3.5e-07 30.4 21.3 5.0 3 1 1 4 4 4 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator FlxA PF14282.4 001108826.1_45726001_3 - 0.0043 16.9 14.2 0.0043 16.9 14.2 4.6 3 1 1 4 4 4 1 FlxA-like protein Mucin PF01456.15 001108826.1_45726001_3 - 0.088 12.7 10.5 0.21 11.4 10.5 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF4407 PF14362.4 001108826.1_45726001_3 - 0.65 9.2 46.8 0.0093 15.2 16.2 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) DUF3439 PF11921.6 001108826.1_45726001_3 - 8.4 6.3 9.5 23 4.9 9.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) UQ_con PF00179.24 001108344.2_45722001_3 - 6.4e-41 139.1 0.0 1e-40 138.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.4 001108344.2_45722001_3 - 0.0056 16.2 0.0 0.0095 15.5 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.20 001108344.2_45722001_3 - 0.02 15.0 0.0 0.033 14.3 0.0 1.4 1 0 0 1 1 1 0 RWD domain UEV PF05743.11 001108344.2_45722001_3 - 0.066 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 UEV domain HOOK PF05622.10 001136098.1_45726001_2 - 0 1053.7 77.2 0 1053.5 77.2 1.0 1 0 0 1 1 1 1 HOOK protein HALZ PF02183.16 001136098.1_45726001_2 - 0.0015 18.5 2.4 0.0015 18.5 2.4 7.2 9 0 0 9 9 9 2 Homeobox associated leucine zipper Shugoshin_N PF07558.9 001136098.1_45726001_2 - 0.0022 17.7 1.9 0.0022 17.7 1.9 3.7 3 0 0 3 3 3 1 Shugoshin N-terminal coiled-coil region Spc7 PF08317.9 001136098.1_45726001_2 - 0.0048 15.7 21.1 0.0048 15.7 21.1 5.1 1 1 4 5 5 5 3 Spc7 kinetochore protein Reo_sigmaC PF04582.10 001136098.1_45726001_2 - 0.041 13.2 22.8 0.18 11.1 1.8 4.1 3 1 2 5 5 5 0 Reovirus sigma C capsid protein CH_2 PF06294.9 001136098.1_45726001_2 - 0.049 13.6 0.9 0.17 11.9 0.1 2.4 2 0 0 2 2 2 0 CH-like domain in sperm protein TPR_MLP1_2 PF07926.10 001136098.1_45726001_2 - 0.059 13.3 92.8 0.016 15.1 15.7 6.8 3 2 2 6 6 6 0 TPR/MLP1/MLP2-like protein Mod_r PF07200.11 001136098.1_45726001_2 - 0.65 9.9 87.7 0.059 13.3 23.4 6.5 1 1 4 5 5 5 0 Modifier of rudimentary (Mod(r)) protein Fez1 PF06818.13 001136098.1_45726001_2 - 5 7.4 83.5 1.4 9.2 11.2 4.7 1 1 3 4 4 4 0 Fez1 NPV_P10 PF05531.10 001136098.1_45726001_2 - 5.2 7.5 36.2 0.77 10.1 3.2 7.9 4 3 3 7 7 7 0 Nucleopolyhedrovirus P10 protein TIR PF01582.18 001130463.1_39722001_1 - 4.4e-14 52.5 0.2 2e-13 50.4 0.2 2.0 1 1 0 1 1 1 1 TIR domain Death PF00531.20 001130463.1_39722001_1 - 4.7e-14 52.2 0.8 1.1e-13 51.0 0.1 2.0 3 0 0 3 3 3 1 Death domain TIR_2 PF13676.4 001130463.1_39722001_1 - 2.9e-12 46.7 0.0 5.7e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 TIR domain Sugar_tr PF00083.22 053494.2_45725001_3 - 4.1e-97 325.8 22.8 6.4e-97 325.1 22.8 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 053494.2_45725001_3 - 1.8e-21 76.4 45.3 7.7e-21 74.3 41.2 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.5 053494.2_45725001_3 - 8.5 5.0 12.9 0.21 10.3 0.8 3.0 1 1 3 4 4 4 0 MFS_1 like family Iso_dh PF00180.18 001131309.1_43525001_2 - 6.2e-75 252.4 0.0 8e-75 252.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase zf-UBP PF02148.17 001131309.1_43525001_3 - 0.018 15.3 1.8 0.018 15.3 1.8 1.8 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein Syja_N PF02383.16 001113371.1_45729001_1 - 2.2e-65 220.9 0.0 3.2e-65 220.3 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain DUF1866 PF08952.9 001113371.1_45729001_1 - 1.1e-59 200.3 0.1 1.8e-59 199.6 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1866) Exo_endo_phos PF03372.21 001113371.1_45729001_1 - 4.3e-07 30.0 0.0 1.1e-06 28.7 0.0 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Serinc PF03348.13 001135261.1_43525001_2 - 4.4e-172 572.7 14.1 5.6e-172 572.4 14.1 1.1 1 0 0 1 1 1 1 Serine incorporator (Serinc) Annexin PF00191.18 001133344.1_43523001_1 - 8.6e-93 304.3 11.1 5e-27 93.6 0.7 4.3 4 0 0 4 4 4 4 Annexin MARVEL PF01284.21 001132976.1_43529001_1 - 1.3e-29 102.9 5.2 2.3e-29 102.1 5.2 1.4 1 0 0 1 1 1 1 Membrane-associating domain MOZART2 PF12926.5 001105860.1_45723001_3 - 7.8e-40 134.3 0.3 1.1e-39 133.8 0.3 1.2 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated zf-DHHC PF01529.18 001133280.1_43526001_3 - 1.3e-36 125.5 7.8 1.3e-36 125.5 7.8 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF4714 PF15833.3 001133280.1_43526001_3 - 0.12 12.2 4.4 0.42 10.5 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4714) UPF0182 PF03699.11 001133280.1_43526001_3 - 1.5 6.7 4.3 0.16 9.9 0.1 1.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0182) CD225 PF04505.10 001106314.1_45722001_1 - 2.6e-28 97.8 1.0 4.9e-28 96.9 1.0 1.4 1 0 0 1 1 1 1 Interferon-induced transmembrane protein Keratin_assoc PF09775.7 001106444.1_45723001_3 - 5.3e-54 181.2 5.6 7.3e-54 180.7 5.6 1.1 1 0 0 1 1 1 1 Keratinocyte-associated protein 2 Reprolysin PF01421.17 001160228.1_45729001_2 - 7.8e-67 224.9 0.0 1.3e-66 224.2 0.0 1.4 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 001160228.1_45729001_2 - 6e-31 107.1 5.5 6e-31 107.1 5.5 3.5 3 0 0 3 3 3 1 ADAM cysteine-rich Pep_M12B_propep PF01562.17 001160228.1_45729001_2 - 1.1e-24 87.2 0.0 2.1e-24 86.2 0.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 001160228.1_45729001_2 - 7.5e-22 78.3 1.7 1.3e-21 77.5 1.7 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Disintegrin PF00200.21 001160228.1_45729001_2 - 7e-19 68.3 32.3 7e-19 68.3 32.3 4.3 3 1 0 3 3 3 1 Disintegrin Reprolysin_3 PF13582.4 001160228.1_45729001_2 - 3.4e-15 56.5 0.1 6.4e-15 55.6 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 001160228.1_45729001_2 - 2.1e-13 50.5 0.4 3.2e-13 49.9 0.4 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 001160228.1_45729001_2 - 4.1e-10 39.5 0.3 7.2e-10 38.7 0.3 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Zincin_1 PF06262.9 001160228.1_45729001_2 - 0.082 12.9 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Zinicin-like metallopeptidase Peptidase_M10 PF00413.22 001160228.1_45729001_2 - 0.11 12.2 0.1 0.19 11.4 0.1 1.3 1 0 0 1 1 1 0 Matrixin Perilipin PF03036.14 001113774.1_39523001_1 - 2.9e-124 415.0 7.3 2.4e-123 412.0 7.3 1.9 1 1 0 1 1 1 1 Perilipin family V-SNARE PF05008.13 001113774.1_39523001_1 - 0.01 16.1 0.1 2.4 8.5 0.0 3.0 3 0 0 3 3 3 0 Vesicle transport v-SNARE protein N-terminus ApoO PF09769.7 001113774.1_39523001_1 - 0.029 14.2 0.1 5.1 7.0 0.0 3.0 3 0 0 3 3 3 0 Apolipoprotein O NPV_P10 PF05531.10 001113774.1_39523001_1 - 0.16 12.4 0.1 7.6 6.9 0.0 3.2 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein BACK PF07707.13 001109250.3_45728001_1 - 9.5e-31 105.8 1.0 4.7e-30 103.6 0.3 2.1 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.29 001109250.3_45728001_1 - 1.3e-27 96.0 0.1 2.2e-27 95.4 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain Kelch_1 PF01344.23 001109250.3_45728001_1 - 2.1e-25 87.9 8.1 1.2e-09 37.4 1.4 4.7 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.4 001109250.3_45728001_1 - 3e-14 52.6 4.5 4.6e-06 26.6 0.1 5.3 3 2 2 5 5 5 3 Kelch motif Kelch_2 PF07646.13 001109250.3_45728001_1 - 1.7e-10 40.3 2.2 1e-05 25.1 0.3 3.9 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.4 001109250.3_45728001_1 - 1.8e-09 37.5 0.2 0.00017 21.7 0.0 4.2 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_4 PF13418.4 001109250.3_45728001_1 - 1.9e-08 34.0 0.1 0.0078 16.0 0.0 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain DUF3342 PF11822.6 001109250.3_45728001_1 - 0.088 12.9 0.1 0.41 10.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) HMG_box PF00505.17 001168909.1_40422001_1 - 3.6e-42 142.5 13.1 2.7e-27 94.9 0.7 2.9 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.8 001168909.1_40422001_1 - 1.3e-41 140.9 21.1 3.1e-27 94.8 8.3 2.8 2 1 1 3 3 3 2 HMG-box domain HMG_box_5 PF14887.4 001168909.1_40422001_1 - 0.0075 16.1 16.1 0.18 11.6 3.2 2.5 2 1 0 2 2 2 2 HMG (high mobility group) box 5 Nop14 PF04147.10 001168909.1_40422001_1 - 0.13 10.3 24.1 0.15 10.1 24.1 1.1 1 0 0 1 1 1 0 Nop14-like family Ets PF00178.20 001168909.1_40422001_1 - 2.1 8.7 5.0 11 6.5 0.4 2.4 2 0 0 2 2 2 0 Ets-domain NOA36 PF06524.10 001168909.1_40422001_1 - 6.4 5.9 25.8 0.3 10.3 20.4 1.5 2 0 0 2 2 2 0 NOA36 protein Nucleo_P87 PF07267.9 001168909.1_40422001_1 - 7.6 5.1 17.3 7 5.2 16.8 1.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 zf-RanBP PF00641.16 001025632.2_45725001_1 - 7.4e-13 47.4 7.4 1.1e-12 46.9 7.4 1.3 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RRM_1 PF00076.20 001025632.2_45725001_1 - 2.8e-10 39.7 0.0 1.1e-09 37.8 0.0 1.9 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ST7 PF04184.10 001110369.1_37924001_1 - 0 1073.7 1.9 0 1073.5 1.9 1.0 1 0 0 1 1 1 1 ST7 protein TPR_6 PF13174.4 001110369.1_37924001_1 - 0.00061 20.1 0.0 0.0033 17.8 0.0 2.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.15 001110369.1_37924001_1 - 0.0052 16.7 0.2 4.8 7.4 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat Clathrin PF00637.18 001110369.1_37924001_1 - 0.06 13.1 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Region in Clathrin and VPS TPR_19 PF14559.4 001110369.1_37924001_1 - 0.14 12.5 4.9 0.41 11.1 0.5 3.3 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.26 001110369.1_37924001_1 - 1.4 8.7 3.4 1.1e+02 2.8 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.4 001110369.1_37924001_1 - 2.3 9.1 8.2 15 6.6 0.0 4.6 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.4 001113785.1_45723001_1 - 1.2e-12 48.0 6.5 3.2e-07 30.6 0.7 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.4 001113785.1_45723001_1 - 3.9e-12 45.8 7.7 0.0021 18.6 0.2 5.4 1 1 4 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.15 001113785.1_45723001_1 - 1.8e-11 43.1 11.1 0.00026 20.8 0.5 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.4 001113785.1_45723001_1 - 6.8e-07 29.7 3.6 0.17 12.5 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 001113785.1_45723001_1 - 1.9e-06 27.5 4.7 0.088 12.9 0.1 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.26 001113785.1_45723001_1 - 1.9e-05 24.2 12.6 0.005 16.5 0.1 4.1 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_6 PF13174.4 001113785.1_45723001_1 - 2.3e-05 24.6 2.9 0.86 10.2 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat Wzy_C_2 PF11846.6 001113785.1_45723001_1 - 0.00026 20.9 1.1 0.24 11.2 0.3 2.5 1 1 1 2 2 2 2 Virulence factor membrane-bound polymerase, C-terminal NARP1 PF12569.6 001113785.1_45723001_1 - 0.00029 19.7 5.4 0.0023 16.7 3.6 2.3 1 1 1 2 2 2 1 NMDA receptor-regulated protein 1 Alkyl_sulf_dimr PF14863.4 001113785.1_45723001_1 - 0.0028 18.0 6.0 0.48 10.7 0.4 3.0 1 1 2 3 3 3 2 Alkyl sulfatase dimerisation TPR_17 PF13431.4 001113785.1_45723001_1 - 0.004 17.3 2.0 2.8 8.4 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.4 001113785.1_45723001_1 - 0.0084 16.1 2.1 1.4 9.0 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.4 001113785.1_45723001_1 - 0.015 15.2 1.0 10 6.3 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 001113785.1_45723001_1 - 0.021 14.8 3.8 0.79 9.7 0.1 3.4 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.5 001113785.1_45723001_1 - 0.047 13.8 8.5 0.76 9.9 3.3 3.6 2 1 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 PknG_TPR PF16918.3 001113785.1_45723001_1 - 0.067 11.8 0.1 0.12 10.9 0.1 1.5 1 1 0 1 1 1 0 Protein kinase G tetratricopeptide repeat TPR_20 PF14561.4 001113785.1_45723001_1 - 0.085 13.1 0.8 1.1 9.5 0.1 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.4 001113785.1_45723001_1 - 0.18 11.4 2.9 10 5.8 0.1 3.3 3 0 0 3 3 3 0 TPR repeat TPR_12 PF13424.4 001113785.1_45723001_1 - 1.4 9.1 8.8 5.5 7.2 0.6 3.8 2 1 0 3 3 3 0 Tetratricopeptide repeat Glyco_transf_29 PF00777.16 001037307.1_39723001_1 - 2.8e-83 279.3 0.0 3.4e-83 279.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) G_glu_transpept PF01019.19 001037307.1_39723001_1 - 0.0045 15.7 0.0 0.0061 15.3 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Trypsin PF00089.24 001135591.1_39724001_1 - 9.8e-70 234.7 0.4 1.3e-69 234.3 0.4 1.2 1 0 0 1 1 1 1 Trypsin Gla PF00594.18 001135591.1_39724001_1 - 7e-21 74.0 12.1 1.5e-20 73.0 12.1 1.6 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FXa_inhibition PF14670.4 001135591.1_39724001_1 - 2e-09 37.5 8.6 2e-09 37.5 8.6 2.9 3 0 0 3 3 3 2 Coagulation Factor Xa inhibitory site EGF PF00008.25 001135591.1_39724001_1 - 4.6e-06 26.7 21.6 7.4e-06 26.0 7.7 3.0 3 0 0 3 3 3 2 EGF-like domain Trypsin_2 PF13365.4 001135591.1_39724001_1 - 0.00019 22.2 0.3 0.00042 21.1 0.3 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001135591.1_39724001_1 - 0.00023 21.4 0.1 0.00047 20.4 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) cEGF PF12662.5 001135591.1_39724001_1 - 0.00047 19.9 11.6 0.0026 17.5 0.3 3.9 3 0 0 3 3 3 2 Complement Clr-like EGF-like hEGF PF12661.5 001135591.1_39724001_1 - 0.031 14.8 4.3 0.031 14.8 4.3 3.7 2 1 0 2 2 2 0 Human growth factor-like EGF EGF_2 PF07974.11 001135591.1_39724001_1 - 4.6 7.6 25.1 0.52 10.6 11.1 3.1 2 0 0 2 2 2 0 EGF-like domain FLYWCH_N PF15423.4 001142500.1_26223001_2 - 1e-46 157.3 4.2 1.5e-46 156.8 4.2 1.2 1 0 0 1 1 1 1 FLYWCH-type zinc finger-containing protein Myb_DNA-binding PF00249.29 001134985.1_45724001_3 - 6.7e-19 67.6 0.0 1.8e-10 40.6 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain ELM2 PF01448.22 001134985.1_45724001_3 - 1.5e-12 48.0 0.0 6.4e-12 45.9 0.0 2.2 1 0 0 1 1 1 1 ELM2 domain Myb_DNA-bind_7 PF15963.3 001134985.1_45724001_3 - 3.1e-08 33.3 4.5 0.00038 20.2 0.2 3.2 2 1 1 3 3 3 2 Myb DNA-binding like Myb_DNA-bind_6 PF13921.4 001134985.1_45724001_3 - 5.6e-06 26.4 3.3 0.0029 17.7 0.1 2.9 3 0 0 3 3 3 2 Myb-like DNA-binding domain AAA PF00004.27 001169068.1_40423001_1 - 8.9e-40 136.0 0.0 1.8e-39 135.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.8 001169068.1_40423001_1 - 8.6e-10 38.3 0.7 1.5e-08 34.4 0.0 3.2 4 0 0 4 4 4 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.10 001169068.1_40423001_1 - 1.7e-05 24.1 0.0 3.1e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.4 001169068.1_40423001_1 - 2.5e-05 24.3 0.0 4.7e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.12 001169068.1_40423001_1 - 2.7e-05 24.2 0.0 4.7e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.4 001169068.1_40423001_1 - 6.2e-05 23.3 0.3 0.028 14.7 0.1 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.12 001169068.1_40423001_1 - 0.00021 21.2 0.4 0.0016 18.3 0.3 2.5 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.11 001169068.1_40423001_1 - 0.00027 19.9 0.0 0.00043 19.2 0.0 1.2 1 0 0 1 1 1 1 TIP49 C-terminus Mg_chelatase PF01078.19 001169068.1_40423001_1 - 0.00074 18.8 0.2 0.0015 17.8 0.2 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TsaE PF02367.15 001169068.1_40423001_1 - 0.0016 18.3 0.0 0.0029 17.5 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.15 001169068.1_40423001_1 - 0.0023 17.6 0.0 0.0051 16.5 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.4 001169068.1_40423001_1 - 0.0024 17.8 0.0 0.0061 16.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.4 001169068.1_40423001_1 - 0.0039 17.3 0.5 0.045 13.9 0.3 2.7 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.4 001169068.1_40423001_1 - 0.007 16.8 0.4 0.03 14.7 0.4 2.1 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.4 001169068.1_40423001_1 - 0.015 14.9 0.1 0.31 10.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain ATPase PF06745.11 001169068.1_40423001_1 - 0.028 13.6 0.2 2.3 7.4 0.1 2.4 1 1 1 2 2 2 0 KaiC TPR_8 PF13181.4 001169068.1_40423001_1 - 0.033 14.3 1.6 2.1 8.7 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat NACHT PF05729.10 001169068.1_40423001_1 - 0.045 13.5 0.1 0.11 12.3 0.1 1.6 1 1 0 1 1 1 0 NACHT domain AAA_28 PF13521.4 001169068.1_40423001_1 - 0.049 13.7 0.1 0.11 12.6 0.1 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.14 001169068.1_40423001_1 - 0.054 12.8 0.1 0.094 12.0 0.1 1.3 1 0 0 1 1 1 0 PhoH-like protein RNA_helicase PF00910.20 001169068.1_40423001_1 - 0.071 13.4 0.0 0.16 12.2 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Guanylate_kin PF00625.19 001169068.1_40423001_1 - 0.11 12.0 0.0 0.45 10.1 0.0 2.0 2 0 0 2 2 2 0 Guanylate kinase AAA_30 PF13604.4 001169068.1_40423001_1 - 0.14 11.7 0.0 0.27 10.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.4 001169068.1_40423001_1 - 0.16 11.4 0.3 0.47 9.9 0.3 1.9 1 1 1 2 2 2 0 AAA domain AAA_17 PF13207.4 001169068.1_40423001_1 - 0.25 11.6 0.0 0.25 11.6 0.0 2.1 2 0 0 2 2 1 0 AAA domain TPR_2 PF07719.15 001169068.1_40423001_1 - 1.3 9.1 3.1 32 4.8 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Spectrin PF00435.19 001133814.1_43528001_3 - 2.2e-70 233.7 30.1 4.5e-23 81.6 5.3 4.4 4 0 0 4 4 4 4 Spectrin repeat CH PF00307.29 001133814.1_43528001_3 - 1.2e-53 179.8 1.2 3.3e-26 91.5 0.0 3.1 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.8 001133814.1_43528001_3 - 5.6e-27 93.5 0.0 1.7e-26 92.0 0.0 1.9 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_1 PF00036.30 001133814.1_43528001_3 - 5e-10 38.1 0.1 0.0013 18.0 0.0 3.0 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.4 001133814.1_43528001_3 - 6.5e-07 28.7 0.4 0.0033 17.1 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain CAMSAP_CH PF11971.6 001133814.1_43528001_3 - 3.6e-06 26.6 0.0 0.00011 21.9 0.0 2.5 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_7 PF13499.4 001133814.1_43528001_3 - 7.2e-06 26.2 0.1 2.4e-05 24.6 0.1 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.4 001133814.1_43528001_3 - 0.0023 17.5 0.1 0.038 13.6 0.0 2.8 2 1 1 3 3 3 2 EF-hand domain pair CH_2 PF06294.9 001133814.1_43528001_3 - 0.076 13.0 0.1 2.9 8.0 0.0 3.0 2 0 0 2 2 2 0 CH-like domain in sperm protein ubiquitin PF00240.21 001123354.1_22421001_1 - 1.1e-34 117.8 0.3 1.6e-34 117.3 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.15 001123354.1_22421001_1 - 1.3e-32 111.3 12.3 1.3e-32 111.3 12.3 1.6 2 0 0 2 2 2 1 Ribosomal L40e family Rad60-SLD PF11976.6 001123354.1_22421001_1 - 7.2e-17 60.9 0.4 1.3e-16 60.0 0.4 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 001123354.1_22421001_1 - 1e-05 25.8 0.1 3.4e-05 24.1 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 001123354.1_22421001_1 - 0.0079 16.2 0.0 0.017 15.1 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 001123354.1_22421001_1 - 0.071 13.5 0.1 0.087 13.3 0.1 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Myosin_head PF00063.19 001135158.1_45729001_3 - 1.8e-287 955.0 5.3 1.8e-287 955.0 5.3 3.4 3 1 0 3 3 3 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 001135158.1_45729001_3 - 4.2e-163 544.6 269.0 5.2e-163 544.3 269.0 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.17 001135158.1_45729001_3 - 1.2e-12 47.3 3.0 3.5e-12 45.8 3.0 1.9 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Reo_sigmaC PF04582.10 001135158.1_45729001_3 - 1.4e-05 24.5 72.7 0.0064 15.8 2.8 9.3 1 1 7 9 9 9 7 Reovirus sigma C capsid protein IQ PF00612.25 001135158.1_45729001_3 - 0.0015 18.0 1.8 0.0071 15.9 0.4 2.7 2 0 0 2 2 2 1 IQ calmodulin-binding motif BBP1_C PF15272.4 001135158.1_45729001_3 - 0.003 17.3 16.2 0.003 17.3 16.2 10.5 1 1 8 9 9 9 1 Spindle pole body component BBP1, C-terminal Big_2 PF02368.16 001135158.1_45729001_3 - 0.034 13.9 0.4 0.097 12.4 0.4 1.7 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 2) AAA_22 PF13401.4 001135158.1_45729001_3 - 0.1 12.7 0.0 0.1 12.7 0.0 5.7 3 2 1 4 4 4 0 AAA domain AAA_16 PF13191.4 001135158.1_45729001_3 - 0.48 10.7 0.0 0.48 10.7 0.0 6.1 3 2 1 4 4 4 0 AAA ATPase domain Filament PF00038.19 001135158.1_45729001_3 - 2.2 7.6 230.7 0.022 14.2 10.9 8.5 1 1 8 9 9 9 0 Intermediate filament protein BPS PF08947.8 001134965.1_49826001_3 - 9.2e-29 98.9 0.7 1.8e-28 98.0 0.7 1.5 1 0 0 1 1 1 1 BPS (Between PH and SH2) SH2 PF00017.22 001134965.1_49826001_3 - 8.8e-14 51.2 0.0 1.7e-13 50.3 0.0 1.5 1 0 0 1 1 1 1 SH2 domain RA PF00788.21 001134965.1_49826001_3 - 4.5e-12 46.3 0.2 1.2e-11 44.9 0.2 1.8 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain PH PF00169.27 001134965.1_49826001_3 - 1.7e-09 38.0 0.0 3.4e-09 37.0 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_9 PF15410.4 001134965.1_49826001_3 - 0.1 12.8 0.0 0.34 11.2 0.0 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain Peptidase_S8 PF00082.20 001111122.1_39725001_1 - 4.5e-24 85.1 0.0 9.5e-24 84.0 0.0 1.5 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.14 001111122.1_39725001_1 - 3.1e-06 27.6 0.0 5.3e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 YEATS PF03366.14 001127527.2_45723001_3 - 4.9e-34 116.0 0.4 7.6e-34 115.4 0.4 1.3 1 0 0 1 1 1 1 YEATS family SOGA PF11365.6 001127527.2_45723001_3 - 0.037 15.0 3.7 0.064 14.3 3.7 1.3 1 0 0 1 1 1 0 Protein SOGA DUF342 PF03961.11 001127527.2_45723001_3 - 0.31 9.4 2.9 0.41 9.1 2.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) MMgT PF10270.7 001133933.1_43528001_2 - 2.3e-12 47.0 0.0 4e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 Membrane magnesium transporter FERM_C PF09380.8 001127565.1_45725001_1 - 5e-22 78.0 0.0 1.1e-21 76.9 0.0 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.16 001127565.1_45725001_1 - 3.8e-19 69.1 0.1 6.3e-19 68.4 0.1 1.4 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.8 001127565.1_45725001_1 - 2.9e-18 65.4 0.2 7e-18 64.2 0.2 1.7 1 0 0 1 1 1 1 FERM N-terminal domain FA PF08736.9 001127565.1_45725001_1 - 5e-13 48.8 10.4 5e-13 48.8 10.4 2.5 2 0 0 2 2 2 1 FERM adjacent (FA) ACBP PF00887.17 001127565.1_45725001_1 - 0.012 15.7 0.0 0.027 14.5 0.0 1.6 1 0 0 1 1 1 0 Acyl CoA binding protein CSN8_PSD8_EIF3K PF10075.7 001100831.1_45724001_2 - 1.1e-35 122.6 0.1 1.5e-35 122.2 0.1 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family S-methyl_trans PF02574.14 001014256.2_45724001_3 - 2.9e-45 155.0 0.0 3.6e-45 154.7 0.0 1.1 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Ion_trans PF00520.29 001136522.1_37929001_3 - 4.8e-261 860.9 82.7 3.4e-74 249.0 18.3 4.1 4 0 0 4 4 4 4 Ion transport protein CAC1F_C PF16885.3 001136522.1_37929001_3 - 1.4e-37 130.1 9.7 1.8e-27 96.9 0.0 3.1 3 0 0 3 3 3 2 Voltage-gated calcium channel subunit alpha, C-term GPHH PF16905.3 001136522.1_37929001_3 - 2.8e-36 123.0 0.0 6e-36 122.0 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 001136522.1_37929001_3 - 2.4e-30 104.5 0.1 5.5e-30 103.3 0.1 1.6 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 001136522.1_37929001_3 - 4.4e-10 38.7 30.1 3.8e-08 32.3 7.3 8.3 7 2 1 8 8 8 4 Polycystin cation channel Etmic-2 PF06670.9 001136522.1_37929001_3 - 0.012 14.4 0.4 0.021 13.6 0.4 1.3 1 0 0 1 1 1 0 Microneme protein Etmic-2 Rer1 PF03248.11 001136522.1_37929001_3 - 0.9 9.1 11.6 2.5 7.7 3.0 4.7 4 0 0 4 4 4 0 Rer1 family bZIP_Maf PF03131.15 001105637.2_06524001_2 - 2.1e-34 117.8 11.9 3.3e-34 117.2 11.9 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor Maf_N PF08383.9 001105637.2_06524001_2 - 3.8e-20 71.2 0.5 8.2e-20 70.2 0.5 1.6 1 0 0 1 1 1 1 Maf N-terminal region ZapB PF06005.10 001105637.2_06524001_2 - 0.0063 16.8 0.9 0.0063 16.8 0.9 2.2 2 0 0 2 2 2 1 Cell division protein ZapB bZIP_1 PF00170.19 001105637.2_06524001_2 - 0.016 15.2 9.5 0.029 14.3 9.5 1.4 1 0 0 1 1 1 0 bZIP transcription factor DUF1192 PF06698.9 001105637.2_06524001_2 - 0.018 14.9 0.5 8 6.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) bZIP_2 PF07716.13 001105637.2_06524001_2 - 0.037 14.0 6.7 0.031 14.2 5.2 1.6 1 1 0 1 1 1 0 Basic region leucine zipper HOOK PF05622.10 001105637.2_06524001_2 - 0.082 10.9 5.2 0.11 10.5 5.2 1.1 1 0 0 1 1 1 0 HOOK protein vATP-synt_E PF01991.16 001105637.2_06524001_2 - 0.27 10.5 4.2 0.42 9.9 4.2 1.3 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit JIP_LZII PF16471.3 001105637.2_06524001_2 - 0.39 10.8 6.1 0.1 12.7 1.5 2.1 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II Sporozoite_P67 PF05642.9 001105637.2_06524001_2 - 0.71 7.7 7.1 1 7.2 7.1 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TraT PF05818.10 001105637.2_06524001_2 - 2.6 7.5 14.9 0.08 12.5 0.8 2.2 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein DivIC PF04977.13 001105637.2_06524001_2 - 8.5 6.1 6.2 1.7 8.3 1.9 1.9 2 0 0 2 2 2 0 Septum formation initiator Serpin PF00079.18 172852.3_32924001_1 - 1.8e-114 382.8 0.5 2.1e-114 382.6 0.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Ph1570 PF09638.8 172852.3_32924001_1 - 0.021 14.6 0.2 0.056 13.2 0.1 1.7 1 1 1 2 2 2 0 Ph1570 protein Glyco_trans_4_3 PF12000.6 172852.3_32924001_1 - 0.025 14.1 0.0 0.042 13.4 0.0 1.3 1 0 0 1 1 1 0 Gkycosyl transferase family 4 group Lip_prot_lig_C PF10437.7 172852.3_32924001_1 - 0.064 13.1 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial lipoate protein ligase C-terminus RGS PF00615.17 019337.1_45722001_1 - 9e-33 112.9 6.9 1.4e-32 112.3 6.9 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.9 019337.1_45722001_1 - 0.0015 18.1 0.2 0.0022 17.6 0.2 1.2 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain Ribosomal_L35Ae PF01247.16 001132630.1_43522001_3 - 2.4e-47 158.9 0.4 2.4e-47 158.9 0.4 1.7 2 0 0 2 2 2 1 Ribosomal protein L35Ae RimM PF01782.16 001132630.1_43522001_3 - 0.021 14.9 0.0 0.99 9.5 0.0 2.3 2 0 0 2 2 2 0 RimM N-terminal domain DUF4604 PF15377.4 001132630.1_43522001_3 - 0.49 10.7 16.0 0.71 10.2 16.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4604) Ion_trans PF00520.29 001168733.1_40429001_2 - 3.9e-41 140.8 0.0 5.2e-41 140.4 0.0 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 001168733.1_40429001_2 - 7.9e-25 86.9 0.0 1.5e-24 86.0 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 001168733.1_40429001_2 - 3.5e-10 39.6 4.7 7.1e-10 38.6 4.7 1.5 1 0 0 1 1 1 1 Ion channel Reticulon PF02453.15 001135804.1_45727001_2 - 0.00025 20.9 5.6 0.00025 20.9 5.6 1.7 2 0 0 2 2 2 1 Reticulon CHGN PF05679.14 178537.4_26227001_1 - 3e-25 88.9 0.0 1e-24 87.2 0.0 1.7 1 1 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase PA14 PF07691.10 178537.4_26227001_1 - 1.2e-16 60.6 0.0 2.2e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 PA14 domain Glyco_transf_7C PF02709.12 178537.4_26227001_1 - 1.1e-13 50.5 0.6 2e-13 49.7 0.6 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Adaptin_N PF01602.18 001107646.1_45728001_2 - 1.1e-79 268.2 5.6 1.4e-79 268.0 5.6 1.1 1 0 0 1 1 1 1 Adaptin N terminal region AP3B1_C PF14796.4 001107646.1_45728001_2 - 1.4e-57 194.0 0.0 2.8e-57 193.0 0.0 1.5 1 0 0 1 1 1 1 Clathrin-adaptor complex-3 beta-1 subunit C-terminal SEEEED PF14797.4 001107646.1_45728001_2 - 5.9e-22 78.0 88.8 4.5e-21 75.2 88.8 2.0 1 1 0 1 1 1 1 Serine-rich region of AP3B1, clathrin-adaptor complex Cnd1 PF12717.5 001107646.1_45728001_2 - 0.0052 16.7 1.3 1.1 9.2 0.4 2.4 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 BUD22 PF09073.8 001107646.1_45728001_2 - 0.078 12.2 50.7 0.11 11.7 50.7 1.1 1 0 0 1 1 1 0 BUD22 Macoilin PF09726.7 001107646.1_45728001_2 - 3.8 5.8 21.3 6.4 5.1 21.3 1.2 1 0 0 1 1 1 0 Transmembrane protein MIP-T3 PF10243.7 001107646.1_45728001_2 - 4.1 5.9 41.5 6.5 5.2 41.5 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 GREB1 PF15782.3 001107646.1_45728001_2 - 7.2 3.4 17.6 9.8 3.0 17.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Adaptin_N PF01602.18 001107646.1_45728001_3 - 5.9e-60 203.2 0.1 8.2e-60 202.7 0.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.5 001107646.1_45728001_3 - 3.4e-18 66.1 1.1 5.7e-18 65.3 1.1 1.3 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.4 001107646.1_45728001_3 - 2.8e-07 30.7 1.2 2.9e-05 24.2 0.2 2.6 2 1 1 3 3 3 2 HEAT repeats HEAT PF02985.20 001107646.1_45728001_3 - 4.3e-05 23.2 0.4 1.8 8.9 0.0 3.6 3 0 0 3 3 3 2 HEAT repeat HEAT_EZ PF13513.4 001107646.1_45728001_3 - 0.03 14.6 0.0 10 6.5 0.1 2.7 2 0 0 2 2 2 0 HEAT-like repeat Pkinase PF00069.23 031657.3_45726001_3 - 1.3e-68 231.1 0.0 1.7e-68 230.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 031657.3_45726001_3 - 1.9e-35 122.2 0.0 2.6e-35 121.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.17 031657.3_45726001_3 - 4.4e-18 65.5 0.1 1.3e-17 64.0 0.0 1.8 2 0 0 2 2 2 1 Regulator of G protein signaling domain Kinase-like PF14531.4 031657.3_45726001_3 - 0.00015 21.0 0.0 0.00025 20.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Trypsin PF00089.24 001134555.1_45726001_2 - 2e-49 168.3 0.0 2.8e-49 167.8 0.0 1.2 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 001134555.1_45726001_2 - 1.3e-48 163.8 0.0 2.3e-28 98.6 0.0 2.4 2 0 0 2 2 2 2 CUB domain Sushi PF00084.18 001134555.1_45726001_2 - 3e-18 66.1 16.3 7.9e-13 48.7 0.4 3.8 3 0 0 3 3 3 2 Sushi repeat (SCR repeat) FXa_inhibition PF14670.4 001134555.1_45726001_2 - 1.6e-09 37.8 10.8 2.2e-09 37.3 7.5 2.7 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site EGF_CA PF07645.13 001134555.1_45726001_2 - 5.3e-06 26.4 5.3 5.3e-06 26.4 5.3 2.7 3 0 0 3 3 3 1 Calcium-binding EGF domain cEGF PF12662.5 001134555.1_45726001_2 - 6.7e-06 25.8 6.9 0.00021 21.0 3.7 2.9 2 0 0 2 2 2 1 Complement Clr-like EGF-like hEGF PF12661.5 001134555.1_45726001_2 - 0.0067 16.9 4.1 0.0067 16.9 4.1 2.6 2 0 0 2 2 2 1 Human growth factor-like EGF EGF PF00008.25 001134555.1_45726001_2 - 0.0076 16.4 5.2 0.0076 16.4 5.2 2.8 3 0 0 3 3 3 1 EGF-like domain Trypsin_2 PF13365.4 001134555.1_45726001_2 - 0.029 15.1 0.0 0.057 14.2 0.0 1.5 1 0 0 1 1 1 0 Trypsin-like peptidase domain VHS PF00790.17 001100519.1_45726001_1 - 3.6e-45 153.1 0.6 8.4e-45 152.0 0.0 1.9 3 0 0 3 3 3 1 VHS domain Alpha_adaptinC2 PF02883.18 001100519.1_45726001_1 - 2e-26 92.3 0.0 3.1e-26 91.7 0.0 1.3 1 0 0 1 1 1 1 Adaptin C-terminal domain GAT PF03127.12 001100519.1_45726001_1 - 7.1e-18 64.6 2.5 1.3e-16 60.5 0.0 2.4 2 0 0 2 2 2 1 GAT domain Phospholip_B PF04916.11 139255.3_45725001_3 - 2.2e-173 577.5 0.0 2.7e-173 577.2 0.0 1.0 1 0 0 1 1 1 1 Phospholipase B Pkinase_Tyr PF07714.15 001104952.1_49826001_3 - 1.1e-88 296.8 0.3 1.6e-88 296.2 0.3 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001104952.1_49826001_3 - 1.2e-47 162.4 0.0 2.1e-47 161.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 001104952.1_49826001_3 - 3.8e-40 135.7 0.4 1.7e-19 69.5 0.1 2.4 2 0 0 2 2 2 2 SH2 domain Kdo PF06293.12 001104952.1_49826001_3 - 0.00062 19.0 0.1 0.0011 18.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 001104952.1_49826001_3 - 0.15 11.5 0.5 0.27 10.7 0.5 1.3 1 0 0 1 1 1 0 RIO1 family 2-oxoacid_dh PF00198.21 001006981.2_45726001_2 - 1.6e-79 266.5 0.2 2.2e-79 266.1 0.2 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.20 001006981.2_45726001_2 - 4.6e-21 74.3 0.3 7.6e-21 73.6 0.3 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.4 001006981.2_45726001_2 - 0.0027 17.4 0.0 0.0055 16.4 0.0 1.4 1 0 0 1 1 1 1 Biotin-lipoyl like GCV_H PF01597.17 001006981.2_45726001_2 - 0.062 13.1 0.3 0.11 12.3 0.3 1.3 1 0 0 1 1 1 0 Glycine cleavage H-protein DUF3915 PF13054.4 001006981.2_45726001_2 - 2.7 7.8 4.3 0.65 9.9 0.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) DUF3528 PF12045.6 001129878.1_45725001_1 - 1.7e-63 213.3 0.2 2.4e-63 212.8 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3528) Homeobox PF00046.27 001129878.1_45725001_1 - 1.4e-19 69.5 7.4 2.3e-19 68.8 7.4 1.3 1 0 0 1 1 1 1 Homeobox domain Dehydrin PF00257.17 001129878.1_45725001_1 - 0.0099 16.3 4.0 0.014 15.8 4.0 1.1 1 0 0 1 1 1 1 Dehydrin Homeobox_KN PF05920.9 001129878.1_45725001_1 - 0.15 11.9 0.8 0.28 11.0 0.8 1.4 1 0 0 1 1 1 0 Homeobox KN domain Guanylin PF02058.13 001160275.1_49821001_2 - 2e-33 114.6 0.9 2.5e-33 114.3 0.9 1.1 1 0 0 1 1 1 1 Guanylin precursor Enterotoxin_ST PF02048.14 001160275.1_49821001_2 - 0.12 12.7 4.5 0.23 11.8 4.5 1.4 1 0 0 1 1 1 0 Heat-stable enterotoxin ST Scs3p PF10261.7 001128460.1_49822001_1 - 1.3e-27 96.8 19.3 1.1e-19 70.8 5.1 2.4 1 1 1 2 2 2 2 Inositol phospholipid synthesis and fat-storage-inducing TM ARL6IP6 PF15062.4 001128460.1_49822001_1 - 0.0032 17.4 0.2 0.0032 17.4 0.2 2.2 2 1 1 3 3 3 1 Haemopoietic lineage transmembrane helix PAP2 PF01569.19 001128460.1_49822001_1 - 0.0068 16.1 11.3 0.0068 16.1 11.3 2.3 1 1 1 2 2 2 1 PAP2 superfamily BAR_3_WASP_bdg PF10456.7 001127488.1_45728001_3 - 6.5e-109 362.8 3.3 8.3e-109 362.4 3.3 1.1 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein PX PF00787.22 001127488.1_45728001_3 - 4.1e-20 71.7 0.9 9.3e-20 70.6 0.9 1.6 1 0 0 1 1 1 1 PX domain SH3_9 PF14604.4 001127488.1_45728001_3 - 6.9e-12 44.9 0.0 1.5e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001127488.1_45728001_3 - 7.9e-09 34.9 0.0 1.7e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 001127488.1_45728001_3 - 1.8e-08 33.8 0.0 4.3e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Vps5 PF09325.8 001127488.1_45728001_3 - 0.018 14.4 1.6 0.097 12.1 0.7 2.4 1 1 1 2 2 2 0 Vps5 C terminal like HBM PF16591.3 001127488.1_45728001_3 - 0.074 12.3 0.0 0.35 10.1 0.0 1.8 1 1 0 1 1 1 0 Helical bimodular sensor domain INSIG PF07281.10 001168911.1_40422001_1 - 6e-48 163.2 6.5 4e-47 160.5 6.5 2.0 1 1 0 1 1 1 1 Insulin-induced protein (INSIG) SLAC1 PF03595.15 001168911.1_40422001_1 - 0.0035 16.6 8.7 0.012 14.8 8.7 1.7 1 1 0 1 1 1 1 Voltage-dependent anion channel DUF202 PF02656.13 001168911.1_40422001_1 - 6.8 7.1 11.0 0.87 9.9 1.7 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF202) DUF1049 PF06305.9 001168911.1_40422001_1 - 7.1 6.4 7.8 3.9 7.2 1.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) SSF PF00474.15 001110422.1_49825001_3 - 4.3e-140 467.0 21.1 5.7e-140 466.6 21.1 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family Yeast_MT PF11403.6 001110422.1_49825001_3 - 0.23 11.9 2.1 0.47 10.9 2.1 1.4 1 0 0 1 1 1 0 Yeast metallothionein IBV_3C PF03620.11 001110422.1_49825001_3 - 0.85 10.0 5.3 0.23 11.8 1.0 2.3 2 0 0 2 2 2 0 IBV 3C protein zf-H2C2_2 PF13465.4 001107237.1_45725001_3 - 2.2e-14 53.0 29.4 3.4e-06 27.1 3.9 5.7 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.24 001107237.1_45725001_3 - 1.2e-13 50.5 40.3 1.3e-05 25.3 0.4 5.8 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001107237.1_45725001_3 - 2.3e-08 34.0 37.1 0.00028 21.3 0.4 5.7 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001107237.1_45725001_3 - 0.0071 15.9 0.2 0.0071 15.9 0.2 4.0 5 0 0 5 5 5 1 zinc-finger C2H2-type zf-H2C2_5 PF13909.4 001107237.1_45725001_3 - 0.0077 15.8 0.1 0.0077 15.8 0.1 5.2 6 0 0 6 6 6 2 C2H2-type zinc-finger domain GAGA PF09237.9 001107237.1_45725001_3 - 0.1 12.3 1.5 0.21 11.3 0.0 2.2 1 1 1 2 2 2 0 GAGA factor zf-C2HE PF16278.3 001107237.1_45725001_3 - 0.12 12.7 0.1 0.12 12.7 0.1 4.3 3 1 1 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_6 PF13912.4 001107237.1_45725001_3 - 0.26 11.2 32.3 0.96 9.3 5.7 5.0 5 0 0 5 5 5 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001107237.1_45725001_3 - 1.2 9.4 17.6 0.89 9.8 1.2 4.7 3 1 1 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.3 001107237.1_45725001_3 - 1.4 9.2 9.0 0.13 12.4 1.3 2.7 2 1 1 3 3 3 0 C2H2-type zinc ribbon Ribosomal_L30_N PF08079.10 001123192.1_49825001_1 - 4.8e-20 71.5 4.2 1e-19 70.4 4.2 1.6 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.18 001123192.1_49825001_1 - 1.1e-13 50.8 0.7 2.7e-13 49.5 0.7 1.7 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e ThiF PF00899.19 057205.2_45725001_2 - 6.7e-67 225.3 0.0 1e-66 224.7 0.0 1.1 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.8 057205.2_45725001_2 - 4.4e-24 84.3 0.7 6.5e-24 83.8 0.7 1.3 1 0 0 1 1 1 1 E2 binding domain UAE_UbL PF14732.4 057205.2_45725001_2 - 0.0012 19.3 0.1 0.0025 18.3 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Shikimate_DH PF01488.18 057205.2_45725001_2 - 0.0024 17.8 0.0 0.0048 16.8 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.25 057205.2_45725001_2 - 0.17 12.4 0.0 0.33 11.4 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Mob_synth_C PF06463.11 001106881.1_45724001_2 - 3.7e-41 139.9 0.0 6.3e-41 139.2 0.0 1.4 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.19 001106881.1_45724001_2 - 1.1e-31 110.3 0.1 1.7e-31 109.7 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.4 001106881.1_45724001_2 - 5.4e-09 36.3 0.0 1e-08 35.4 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.4 001106881.1_45724001_2 - 2.9e-05 24.0 0.0 6.9e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain 2-Hacid_dh_C PF02826.17 001113754.1_45723001_2 - 5.2e-59 198.4 0.0 9e-59 197.7 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.28 001113754.1_45723001_2 - 1.5e-25 89.3 0.0 1.8e-25 89.0 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.13 001113754.1_45723001_2 - 9.1e-07 29.0 0.0 1.4e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.15 001113754.1_45723001_2 - 4e-05 24.0 0.0 8.3e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent KR PF08659.8 001113754.1_45723001_2 - 0.0025 17.6 0.1 0.16 11.8 0.0 2.8 2 1 0 2 2 2 1 KR domain Shikimate_DH PF01488.18 001113754.1_45723001_2 - 0.011 15.6 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase IlvN PF07991.10 001113754.1_45723001_2 - 0.061 12.8 0.0 0.088 12.2 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.16 001113754.1_45723001_2 - 0.12 12.5 0.0 0.31 11.2 0.0 1.7 2 0 0 2 2 2 0 TrkA-N domain Glyco_hydro_2_C PF02836.15 017015.2_45725001_1 - 1.7e-110 368.8 0.0 2.2e-110 368.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.16 017015.2_45725001_1 - 2.6e-20 72.9 0.1 4.6e-20 72.1 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.19 017015.2_45725001_1 - 1.3e-08 35.3 0.0 2.2e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 PI3_PI4_kinase PF00454.25 001168952.1_40425001_1 - 4.1e-34 118.4 0.2 3.6e-31 108.7 0.2 2.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF4135 PF13575.4 001168952.1_40425001_1 - 0.021 14.0 0.0 0.034 13.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) JAB PF01398.19 001110812.1_39723001_3 - 6.9e-27 93.6 0.0 1e-26 93.1 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.4 001110812.1_39723001_3 - 1.8e-24 86.2 0.1 3.2e-24 85.4 0.1 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function zf-FCS PF06467.12 001108681.2_45729001_1 - 1.8e-21 75.7 79.6 5e-07 29.5 4.3 9.4 8 1 0 8 8 8 8 MYM-type Zinc finger with FCS sequence motif DUF4371 PF14291.4 001108681.2_45729001_1 - 0.004 16.8 0.0 0.0073 15.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) Dimer_Tnp_hAT PF05699.12 001108681.2_45729001_1 - 0.0096 15.6 0.3 0.026 14.2 0.3 1.7 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region YHS PF04945.11 001108681.2_45729001_1 - 0.025 14.6 29.5 0.25 11.3 0.6 7.0 7 0 0 7 7 7 0 YHS domain MBT PF02820.16 001109669.1_45726001_1 - 3.5e-49 164.9 0.0 1.5e-25 89.2 0.0 2.3 2 0 0 2 2 2 2 mbt repeat SLED PF12140.6 001109669.1_45726001_1 - 3e-36 124.2 0.1 5e-36 123.5 0.1 1.4 1 0 0 1 1 1 1 SLED domain SAM_1 PF00536.28 001109669.1_45726001_1 - 1.2e-15 57.5 0.2 2.2e-15 56.7 0.2 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RBR PF17208.1 001109669.1_45726001_1 - 1.6e-10 41.4 18.7 1.6e-10 41.4 18.7 2.2 2 0 0 2 2 2 1 RNA binding Region SAM_2 PF07647.15 001109669.1_45726001_1 - 9.6e-08 31.9 0.0 1.9e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 001109669.1_45726001_1 - 0.00051 19.8 0.0 0.0009 19.0 0.0 1.3 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain TMEM174 PF15029.4 153217.2_26224001_1 - 2.7e-118 393.7 0.5 3.4e-118 393.3 0.5 1.1 1 0 0 1 1 1 1 Transmembrane protein 174 Spc97_Spc98 PF04130.11 001107560.2_45726001_3 - 4.3e-122 408.5 11.1 1.3e-121 406.9 11.1 1.8 1 1 0 1 1 1 1 Spc97 / Spc98 family zf-Tim10_DDP PF02953.13 001107560.2_45726001_3 - 0.016 14.7 2.7 0.038 13.5 2.7 1.6 1 0 0 1 1 1 0 Tim10/DDP family zinc finger DUF2894 PF11445.6 001107560.2_45726001_3 - 0.12 12.7 1.7 0.36 11.1 1.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2894) AIRS_C PF02769.20 001131218.1_43527001_1 - 3.4e-30 105.1 0.1 4.7e-30 104.6 0.1 1.2 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.22 001131218.1_43527001_1 - 4.6e-10 39.9 0.3 9.7e-10 38.8 0.3 1.5 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain MFS_1 PF07690.14 001144991.1_45728001_2 - 3e-35 121.7 27.8 3e-35 121.7 27.8 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.22 001144991.1_45728001_2 - 1.9e-13 50.0 6.6 1.9e-13 50.0 6.6 2.9 2 1 0 3 3 3 1 Sugar (and other) transporter OATP PF03137.18 001144991.1_45728001_2 - 7.3e-11 40.9 19.0 1e-05 24.0 1.3 4.2 2 2 2 4 4 4 3 Organic Anion Transporter Polypeptide (OATP) family zf-RING_2 PF13639.4 001024235.2_45729001_1 - 7.3e-07 29.2 8.3 2.9e-06 27.3 8.3 2.2 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.6 001024235.2_45729001_1 - 6.3e-05 22.9 8.5 0.00027 20.9 8.5 2.1 1 0 0 1 1 1 1 FANCL C-terminal domain zf-ANAPC11 PF12861.5 001024235.2_45729001_1 - 0.00035 20.4 1.9 0.00035 20.4 1.9 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.5 001024235.2_45729001_1 - 0.00088 19.4 7.3 0.0038 17.4 7.3 2.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain RINGv PF12906.5 001024235.2_45729001_1 - 0.0071 16.3 6.7 0.034 14.1 6.7 2.4 1 0 0 1 1 1 1 RING-variant domain zf-C3HC4 PF00097.23 001024235.2_45729001_1 - 0.015 15.1 9.7 0.045 13.5 9.7 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.3 001024235.2_45729001_1 - 0.076 12.5 5.6 0.37 10.3 5.6 2.2 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.4 001024235.2_45729001_1 - 0.18 11.5 8.6 0.77 9.5 8.6 2.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.9 001024235.2_45729001_1 - 0.23 11.6 6.6 0.87 9.8 6.6 2.0 1 0 0 1 1 1 0 RING-like domain Zf_RING PF16744.3 001024235.2_45729001_1 - 0.39 10.7 3.3 1.3 9.1 3.3 1.9 1 0 0 1 1 1 0 KIAA1045 RING finger TPP_enzyme_N PF02776.16 001108738.1_45726001_1 - 1.3e-51 174.5 3.6 3.4e-51 173.1 3.6 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.19 001108738.1_45726001_1 - 9.4e-27 93.5 0.4 4.3e-26 91.4 0.0 2.3 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.20 001108738.1_45726001_1 - 9.4e-15 54.4 0.0 4e-14 52.4 0.0 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain CO_dh PF02552.14 001108738.1_45726001_1 - 0.14 11.8 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit eIF2_C PF09173.9 001100542.1_45728001_3 - 1.1e-36 124.8 0.5 2.5e-36 123.7 0.5 1.6 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.25 001100542.1_45728001_3 - 3.8e-22 78.7 0.3 1.6e-21 76.7 0.3 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.23 001100542.1_45728001_3 - 3.8e-12 46.3 0.3 7.5e-12 45.3 0.3 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 001100542.1_45728001_3 - 0.022 14.7 0.0 0.039 13.9 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF258 PF03193.14 001100542.1_45728001_3 - 0.027 14.2 0.5 0.098 12.4 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF258 MMR_HSR1_Xtn PF16897.3 001100542.1_45728001_3 - 0.05 13.5 0.1 0.096 12.6 0.1 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Tetraspannin PF00335.18 001115032.1_45724001_2 - 3.8e-48 163.9 9.2 5e-48 163.6 9.2 1.2 1 0 0 1 1 1 1 Tetraspanin family CD20 PF04103.13 001115032.1_45724001_2 - 0.042 13.8 5.6 0.066 13.2 4.7 1.8 1 1 0 1 1 1 0 CD20-like family DUF2157 PF09925.7 001115032.1_45724001_2 - 0.18 11.5 3.3 0.29 10.8 2.1 1.9 1 1 0 1 1 1 0 Predicted membrane protein (DUF2157) WD40 PF00400.30 001115035.1_45723001_3 - 9.6e-26 89.4 1.0 4.9e-06 27.0 1.6 6.2 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001115035.1_45723001_3 - 1.5e-13 50.7 0.0 0.0019 18.3 0.0 5.1 2 2 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 001115035.1_45723001_3 - 3.4e-05 22.9 0.6 0.011 14.6 0.0 3.0 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein ISN1 PF06437.9 001115035.1_45723001_3 - 0.098 11.5 0.1 2.1 7.1 0.0 2.0 2 0 0 2 2 2 0 IMP-specific 5'-nucleotidase Lys PF00062.18 001112642.1_40421001_1 - 1.2e-57 193.4 3.9 1.3e-57 193.3 3.9 1.0 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family SLT PF01464.18 001112642.1_40421001_1 - 0.0059 16.1 0.0 0.0084 15.6 0.0 1.2 1 0 0 1 1 1 1 Transglycosylase SLT domain DUF3395 PF11875.6 001108694.2_45725001_1 - 7.3e-47 159.0 0.3 7.3e-47 159.0 0.3 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3395) DnaJ PF00226.29 001108694.2_45725001_1 - 9.9e-22 76.7 1.2 9.9e-22 76.7 1.2 2.0 2 0 0 2 2 2 1 DnaJ domain Selenoprotein_S PF06936.9 001108694.2_45725001_1 - 0.036 13.7 0.1 0.081 12.6 0.1 1.5 1 0 0 1 1 1 0 Selenoprotein S (SelS) DUF4736 PF15883.3 001108694.2_45725001_1 - 0.08 12.5 0.8 0.15 11.7 0.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4736) DUF1681 PF07933.12 001029919.2_45725001_2 - 2.6e-55 186.0 0.0 3.5e-55 185.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) Ion_trans PF00520.29 001135850.1_39729001_2 - 2.9e-41 141.2 0.0 4e-41 140.7 0.0 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 001135850.1_39729001_2 - 5.1e-26 90.7 0.0 8.7e-26 90.0 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 001135850.1_39729001_2 - 3e-10 39.8 4.7 7e-10 38.6 4.7 1.6 1 0 0 1 1 1 1 Ion channel Myosin_head PF00063.19 001107794.2_45729001_1 - 3.4e-285 947.4 0.0 7.2e-285 946.4 0.0 1.6 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_tail_1 PF01576.17 001107794.2_45729001_1 - 5.1e-146 488.0 269.6 6.9e-146 487.6 269.6 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.17 001107794.2_45729001_1 - 1.1e-12 47.3 6.0 2.6e-12 46.2 6.0 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Reo_sigmaC PF04582.10 001107794.2_45729001_1 - 1.8e-05 24.2 64.0 0.00094 18.5 2.4 8.4 3 3 6 9 9 9 7 Reovirus sigma C capsid protein Filament PF00038.19 001107794.2_45729001_1 - 8.6e-05 22.1 41.3 8.6e-05 22.1 41.3 8.4 1 1 7 8 8 8 3 Intermediate filament protein AAA_22 PF13401.4 001107794.2_45729001_1 - 0.09 12.9 0.0 0.09 12.9 0.0 6.3 5 2 1 6 6 6 0 AAA domain Hydantoinase_A PF01968.16 001107794.2_45729001_1 - 1.3 8.0 4.2 5.5 6.0 4.2 2.1 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase RhoGEF PF00621.18 001108409.1_45726001_3 - 4.9e-44 150.6 0.0 8.1e-44 149.9 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.27 001108409.1_45726001_3 - 2e-17 63.5 0.0 3.7e-11 43.3 0.0 2.4 2 0 0 2 2 2 2 PH domain FYVE PF01363.19 001108409.1_45726001_3 - 1.3e-10 41.1 13.4 2.7e-10 40.1 13.4 1.5 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.14 001108409.1_45726001_3 - 0.00066 19.7 7.5 0.0014 18.7 7.5 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger C1_2 PF03107.14 001108409.1_45726001_3 - 0.078 13.2 3.6 0.2 11.9 3.6 1.7 1 0 0 1 1 1 0 C1 domain PH_13 PF16652.3 001108409.1_45726001_3 - 0.16 11.7 0.5 5.4 6.7 0.8 2.8 3 1 0 3 3 3 0 Pleckstrin homology domain PH_10 PF15411.4 001108409.1_45726001_3 - 0.52 10.5 2.7 19 5.4 2.7 2.5 1 1 0 1 1 1 0 Pleckstrin homology domain C1_1 PF00130.20 001108409.1_45726001_3 - 0.74 9.6 10.7 0.13 12.1 6.6 1.8 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DZR PF12773.5 001108409.1_45726001_3 - 6.3 6.8 11.1 18 5.3 11.1 1.8 1 1 0 1 1 1 0 Double zinc ribbon ADK_lid PF05191.12 001108409.1_45726001_3 - 7.6 6.5 7.1 34 4.5 7.1 2.1 1 1 0 1 1 1 0 Adenylate kinase, active site lid 2OG-FeII_Oxy_2 PF13532.4 001126273.1_45723001_3 - 5.3e-27 95.2 0.0 7.2e-27 94.8 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Cytochrom_B561 PF03188.14 001107056.2_45726001_1 - 2.7e-44 150.5 9.0 2.7e-44 150.5 9.0 1.7 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 HPS3_Mid PF14762.4 001146324.1_32925001_1 - 1.3e-130 435.6 1.4 1.7e-130 435.2 1.4 1.1 1 0 0 1 1 1 1 Hermansky-Pudlak syndrome 3, middle region HPS3_N PF14761.4 001146324.1_32925001_1 - 2.3e-71 239.6 0.4 3.8e-71 238.9 0.4 1.4 1 0 0 1 1 1 1 Hermansky-Pudlak syndrome 3 Metallothio PF00131.18 001133593.2_43521001_1 - 1.5e-19 69.7 64.7 2.1e-19 69.2 64.7 1.2 1 0 0 1 1 1 1 Metallothionein ST7 PF04184.10 001110368.1_37926001_1 - 0 1022.7 2.3 0 1021.9 2.3 1.3 1 1 0 1 1 1 1 ST7 protein TPR_6 PF13174.4 001110368.1_37926001_1 - 0.0012 19.2 0.0 0.0047 17.3 0.0 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.15 001110368.1_37926001_1 - 0.016 15.1 0.2 7 6.9 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Clathrin PF00637.18 001110368.1_37926001_1 - 0.099 12.4 0.1 0.19 11.4 0.1 1.4 1 0 0 1 1 1 0 Region in Clathrin and VPS TPR_14 PF13428.4 001110368.1_37926001_1 - 0.28 12.0 3.2 19 6.3 0.1 4.3 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.4 001110368.1_37926001_1 - 0.3 11.5 4.5 0.56 10.6 0.3 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat Kinesin PF00225.21 001137642.1_45727001_3 - 4.7e-98 328.1 1.5 9.2e-98 327.1 1.5 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 001137642.1_45727001_3 - 8.7e-14 51.6 0.0 2.5e-13 50.1 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding DUF4005 PF13178.4 001137642.1_45727001_3 - 0.068 13.7 1.8 0.22 12.1 1.8 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF4005) DUF2443 PF10398.7 001137642.1_45727001_3 - 0.25 11.3 4.4 0.52 10.3 0.0 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2443) 2OG-FeII_Oxy PF03171.18 001142915.1_45728001_3 - 9.6e-06 25.9 0.0 2.4e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Anp1 PF03452.12 001142915.1_45728001_3 - 4.2e-05 23.0 0.5 0.026 13.8 0.0 2.8 2 1 0 3 3 3 2 Anp1 2OG-FeII_Oxy_3 PF13640.4 001142915.1_45728001_3 - 0.00022 21.9 0.0 0.00049 20.8 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Glycos_transf_2 PF00535.24 001142915.1_45728001_3 - 0.0052 16.5 0.1 0.021 14.5 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase family 2 zf-H2C2_2 PF13465.4 001133263.1_43529001_1 - 7.8e-25 86.0 52.6 2.7e-07 30.6 0.8 7.6 8 1 0 8 8 8 6 Zinc-finger double domain zf-C2H2 PF00096.24 001133263.1_43529001_1 - 2.5e-17 62.2 64.5 2.2e-05 24.5 1.8 8.3 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001133263.1_43529001_1 - 1.4e-14 53.4 61.7 0.0016 18.9 1.6 8.6 8 0 0 8 8 8 6 C2H2-type zinc finger zf-met PF12874.5 001133263.1_43529001_1 - 5e-09 36.1 40.9 0.00033 20.8 1.3 7.3 7 0 0 7 7 7 5 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.4 001133263.1_43529001_1 - 0.0055 16.3 1.2 0.0055 16.3 1.2 5.6 6 0 0 6 6 6 3 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.6 001133263.1_43529001_1 - 0.021 15.0 49.2 0.07 13.3 0.1 7.7 8 0 0 8 8 8 0 Zinc-finger double-stranded RNA-binding Mu-like_Com PF10122.7 001133263.1_43529001_1 - 0.33 10.3 5.6 0.16 11.3 2.9 2.0 2 1 0 2 2 2 0 Mu-like prophage protein Com HypA PF01155.17 001133263.1_43529001_1 - 0.91 9.4 12.7 2.7 7.9 4.8 3.0 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Syja_N PF02383.16 001107554.1_45729001_3 - 1e-93 314.0 0.1 1.7e-93 313.2 0.1 1.4 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.6 001107554.1_45729001_3 - 2.6e-21 75.3 0.0 6.1e-21 74.1 0.0 1.6 1 0 0 1 1 1 1 Inositol phosphatase EST1 PF10374.7 001107554.1_45729001_3 - 0.34 11.4 2.4 1.3 9.5 0.0 2.9 3 0 0 3 3 3 0 Telomerase activating protein Est1 SMK-1 PF04802.13 001108367.1_45729001_3 - 6.5e-81 270.6 6.1 1.5e-80 269.4 6.1 1.7 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 WH1 PF00568.21 001108367.1_45729001_3 - 0.00084 19.1 0.0 0.0016 18.2 0.0 1.4 1 0 0 1 1 1 1 WH1 domain Ran_BP1 PF00638.16 001108367.1_45729001_3 - 0.013 15.6 0.7 0.027 14.6 0.0 1.9 2 0 0 2 2 2 0 RanBP1 domain IGF2_C PF08365.9 001108367.1_45729001_3 - 0.015 15.2 0.1 0.032 14.1 0.1 1.5 1 0 0 1 1 1 0 Insulin-like growth factor II E-peptide Diphtheria_T PF02764.12 001108367.1_45729001_3 - 0.052 13.4 0.0 0.25 11.2 0.0 2.0 2 0 0 2 2 2 0 Diphtheria toxin, T domain Y_phosphatase PF00102.25 053767.1_45725001_2 - 1.1e-164 545.4 6.2 4.9e-83 278.1 0.4 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.18 053767.1_45725001_2 - 1e-10 41.4 0.2 0.00013 21.6 0.0 2.9 3 0 0 3 3 3 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 053767.1_45725001_2 - 4.6e-08 33.2 0.2 0.0054 16.6 0.0 2.8 3 0 0 3 3 3 2 Tyrosine phosphatase family PTPlike_phytase PF14566.4 053767.1_45725001_2 - 3.7e-07 30.3 0.1 0.0078 16.2 0.0 3.1 4 0 0 4 4 4 2 Inositol hexakisphosphate Y_phosphatase2 PF03162.11 053767.1_45725001_2 - 0.0046 16.4 0.1 0.81 9.1 0.0 2.6 2 0 0 2 2 2 1 Tyrosine phosphatase family CcmH PF03918.12 053767.1_45725001_2 - 0.1 11.7 0.0 0.2 10.8 0.0 1.4 1 0 0 1 1 1 0 Cytochrome C biogenesis protein BatD PF13584.4 053767.1_45725001_2 - 0.16 10.7 0.0 0.25 10.0 0.0 1.2 1 0 0 1 1 1 0 Oxygen tolerance Rad60-SLD PF11976.6 133594.2_45723001_2 - 7.7e-25 86.4 0.1 1.2e-24 85.8 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.21 133594.2_45723001_2 - 6.9e-11 41.6 0.1 1e-10 41.1 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family Homeobox_KN PF05920.9 001133033.1_43528001_3 - 2.7e-13 49.4 0.5 5.3e-13 48.5 0.5 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 001133033.1_43528001_3 - 0.00031 20.4 0.2 0.00079 19.1 0.2 1.7 1 0 0 1 1 1 1 Homeobox domain bZIP_Maf PF03131.15 001130573.1_45724001_3 - 2.7e-32 111.0 10.2 4.2e-32 110.4 10.2 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.19 001130573.1_45724001_3 - 0.0032 17.4 14.4 0.0097 15.9 14.4 1.7 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 001130573.1_45724001_3 - 0.075 13.0 12.3 0.19 11.7 12.3 1.7 1 0 0 1 1 1 0 Basic region leucine zipper DivIC PF04977.13 001130573.1_45724001_3 - 0.081 12.6 4.8 0.043 13.4 2.0 1.9 1 1 1 2 2 2 0 Septum formation initiator DUF1192 PF06698.9 001130573.1_45724001_3 - 4.6 7.2 7.2 0.46 10.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) UPF0183 PF03676.12 145604.2_32926001_2 - 3e-160 533.7 0.1 3.5e-160 533.4 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0183) Glyco_hydro_20 PF00728.20 001009333.2_22424001_2 - 6e-94 315.2 0.0 8.1e-94 314.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.4 001009333.2_22424001_2 - 1e-18 68.1 0.0 1.8e-18 67.4 0.0 1.4 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.13 001009333.2_22424001_2 - 0.00041 21.0 0.0 0.0007 20.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Ribosomal_S14 PF00253.19 001105963.2_45723001_3 - 1.5e-23 82.2 3.6 4.2e-22 77.5 0.8 2.3 2 0 0 2 2 2 2 Ribosomal protein S14p/S29e 14-3-3 PF00244.18 001131572.1_43525001_1 - 2.4e-107 357.3 3.5 3e-107 357.0 3.5 1.1 1 0 0 1 1 1 1 14-3-3 protein TIR PF01582.18 001130681.1_29622001_1 - 4.4e-14 52.5 0.2 2e-13 50.4 0.2 2.0 1 1 0 1 1 1 1 TIR domain Death PF00531.20 001130681.1_29622001_1 - 4.7e-14 52.2 0.8 1.1e-13 51.0 0.1 2.0 3 0 0 3 3 3 1 Death domain TIR_2 PF13676.4 001130681.1_29622001_1 - 2.9e-12 46.7 0.0 5.7e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 TIR domain Tropomyosin PF00261.18 001105686.1_37923001_1 - 2.2e-85 285.7 85.0 2.7e-82 275.6 58.9 2.0 1 1 1 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.5 001105686.1_37923001_1 - 1.2e-37 129.0 71.4 4.8e-33 114.2 41.2 2.4 2 0 0 2 2 2 2 Tropomyosin like CLZ PF16526.3 001105686.1_37923001_1 - 4.2e-07 30.1 51.0 1.2e-05 25.5 9.4 5.2 2 2 3 5 5 5 4 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Laminin_II PF06009.10 001105686.1_37923001_1 - 0.00028 20.8 34.9 0.0041 17.0 8.8 3.7 1 1 4 5 5 5 3 Laminin Domain II TMF_DNA_bd PF12329.6 001105686.1_37923001_1 - 0.0024 17.7 16.3 0.0024 17.7 16.3 5.7 2 1 4 6 6 6 3 TATA element modulatory factor 1 DNA binding DUF3450 PF11932.6 001105686.1_37923001_1 - 0.0029 16.8 50.7 0.014 14.6 10.9 2.9 1 1 2 3 3 3 2 Protein of unknown function (DUF3450) NBP1 PF08537.8 001105686.1_37923001_1 - 0.0097 15.2 15.1 0.0097 15.2 15.1 3.4 1 1 2 3 3 3 1 Fungal Nap binding protein NBP1 BST2 PF16716.3 001105686.1_37923001_1 - 0.01 16.3 7.1 0.01 16.3 7.1 4.8 1 1 5 6 6 6 0 Bone marrow stromal antigen 2 ERM PF00769.17 001105686.1_37923001_1 - 0.015 15.0 71.7 0.092 12.4 20.2 3.2 1 1 2 3 3 3 0 Ezrin/radixin/moesin family ATG16 PF08614.9 001105686.1_37923001_1 - 0.094 12.7 66.3 0.023 14.8 20.0 3.4 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) gpW PF02831.13 001105686.1_37923001_1 - 0.19 11.4 4.3 2.5 7.8 0.1 3.3 2 2 0 2 2 2 0 gpW HrpB7 PF09486.8 001105686.1_37923001_1 - 0.48 10.7 47.9 0.14 12.4 4.2 4.1 1 1 3 4 4 4 0 Bacterial type III secretion protein (HrpB7) ADIP PF11559.6 001105686.1_37923001_1 - 0.52 10.3 53.7 0.13 12.2 7.6 4.2 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding Reo_sigmaC PF04582.10 001105686.1_37923001_1 - 0.78 9.0 11.2 2 7.6 2.7 2.3 2 0 0 2 2 2 0 Reovirus sigma C capsid protein DASH_Duo1 PF08651.8 001105686.1_37923001_1 - 1.3 8.7 11.0 0.15 11.7 0.5 3.6 3 1 1 4 4 4 0 DASH complex subunit Duo1 Baculo_PEP_C PF04513.10 001105686.1_37923001_1 - 2 8.3 12.1 1.6 8.6 1.6 3.0 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus AAA_13 PF13166.4 001105686.1_37923001_1 - 2.4 6.6 47.0 4.5 5.7 29.7 2.2 1 1 1 2 2 2 0 AAA domain DUF1664 PF07889.10 001105686.1_37923001_1 - 2.6 7.9 32.5 0.24 11.3 7.1 3.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.7 001105686.1_37923001_1 - 4.9 7.0 68.1 2.5 8.0 27.0 2.6 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IncA PF04156.12 001105686.1_37923001_1 - 5 6.7 62.3 0.38 10.4 24.5 3.0 1 1 1 2 2 1 0 IncA protein Exonuc_VII_L PF02601.13 001105686.1_37923001_1 - 5.4 6.3 38.3 9.7 5.5 20.6 2.2 1 1 1 2 2 2 0 Exonuclease VII, large subunit APG6 PF04111.10 001105686.1_37923001_1 - 5.8 6.1 64.4 1.2 8.3 20.1 3.2 1 1 3 4 4 4 0 Autophagy protein Apg6 Sulfotransfer_2 PF03567.12 001107504.2_45725001_2 - 7.5e-59 199.5 1.2 1e-58 199.1 1.2 1.2 1 0 0 1 1 1 1 Sulfotransferase family Ion_trans_2 PF07885.14 001131696.1_43524001_3 - 4.6e-32 109.7 18.0 7.6e-17 60.9 3.7 3.0 3 0 0 3 3 3 2 Ion channel Na_K-ATPase PF00287.16 001132587.1_43525001_1 - 2.2e-98 328.8 0.1 3.7e-98 328.0 0.1 1.3 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain RRM_1 PF00076.20 001130506.1_45727001_3 - 8e-10 38.3 0.0 1.6e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Arm PF00514.21 001107728.1_45727001_3 - 1.2e-32 110.8 16.4 9.3e-08 31.7 0.1 7.8 7 1 1 8 8 8 4 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.4 001107728.1_45727001_3 - 1.2e-05 25.5 5.7 0.013 15.9 0.1 4.5 4 0 0 4 4 4 2 HEAT-like repeat V-ATPase_H_N PF03224.12 001107728.1_45727001_3 - 4e-05 22.9 6.3 0.0014 17.8 1.0 3.6 1 1 1 2 2 2 1 V-ATPase subunit H HEAT PF02985.20 001107728.1_45727001_3 - 0.00091 19.1 0.7 1.4 9.3 0.0 3.8 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.4 001107728.1_45727001_3 - 0.0018 18.5 5.9 1.8 8.8 0.0 4.4 2 2 3 5 5 4 2 HEAT repeats Atx10homo_assoc PF09759.7 001107728.1_45727001_3 - 0.0042 17.0 0.6 0.037 14.0 0.1 2.6 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain Cnd1 PF12717.5 001107728.1_45727001_3 - 0.012 15.5 9.9 1.1 9.1 0.1 3.8 3 1 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Nitr_red_bet_C PF14711.4 001107728.1_45727001_3 - 0.045 13.3 0.0 0.13 11.8 0.0 1.7 1 0 0 1 1 1 0 Respiratory nitrate reductase beta C-terminal RICTOR_V PF14668.4 001107728.1_45727001_3 - 0.045 13.8 0.8 9.5 6.4 0.1 4.0 3 1 1 4 4 4 0 Rapamycin-insensitive companion of mTOR, domain 5 SNase PF00565.15 001107728.1_45727001_3 - 0.05 13.9 0.1 6.1 7.2 0.1 2.5 2 0 0 2 2 2 0 Staphylococcal nuclease homologue Pkinase PF00069.23 001106422.1_45729001_2 - 2.4e-64 217.1 0.4 5.3e-64 216.0 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain CNH PF00780.20 001106422.1_45729001_2 - 1.9e-60 204.7 0.0 2.9e-60 204.1 0.0 1.3 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.15 001106422.1_45729001_2 - 9.6e-48 162.6 0.0 1.7e-47 161.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ist1 PF03398.12 001133078.1_43525001_2 - 5.6e-61 205.1 2.7 7.4e-61 204.7 2.7 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Rep_fac-A_C PF08646.8 001132818.1_43526001_2 - 8.1e-58 194.2 10.2 8.5e-56 187.6 6.8 2.3 2 0 0 2 2 2 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.3 001132818.1_43526001_2 - 1.1e-35 121.3 2.7 2.1e-34 117.2 0.3 2.8 3 0 0 3 3 3 1 Replication protein A OB domain Rep-A_N PF04057.10 001132818.1_43526001_2 - 3.4e-34 116.8 0.1 6e-34 116.0 0.1 1.4 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.23 001132818.1_43526001_2 - 6.5e-11 42.0 0.8 5.8e-10 38.9 0.0 2.8 3 0 0 3 3 3 1 OB-fold nucleic acid binding domain IBR PF01485.19 001132818.1_43526001_2 - 5.7 7.1 11.2 0.11 12.6 3.3 2.2 3 0 0 3 3 3 0 IBR domain, a half RING-finger domain Tim17 PF02466.17 001108249.1_45722001_2 - 2e-28 98.6 4.3 2.6e-28 98.3 4.3 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Ras PF00071.20 001133077.1_43525001_3 - 8.5e-49 165.1 0.0 1.2e-48 164.6 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001133077.1_43525001_3 - 7e-30 103.6 0.1 1.4e-29 102.6 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001133077.1_43525001_3 - 4.5e-10 39.1 0.0 7.1e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001133077.1_43525001_3 - 0.0013 18.7 0.0 0.0019 18.1 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.20 001133077.1_43525001_3 - 0.0049 17.1 0.0 0.011 15.9 0.0 1.6 1 1 0 1 1 1 1 RNA helicase Gtr1_RagA PF04670.10 001133077.1_43525001_3 - 0.015 14.5 0.0 0.021 14.0 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001133077.1_43525001_3 - 0.016 14.7 0.1 0.042 13.3 0.1 1.6 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_24 PF13479.4 001133077.1_43525001_3 - 0.041 13.5 0.0 0.056 13.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.8 001133077.1_43525001_3 - 0.17 11.2 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PDZ PF00595.22 138535.2_45729001_1 - 7.2e-85 279.3 0.2 3.7e-12 46.3 0.1 7.2 7 0 0 7 7 7 7 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 138535.2_45729001_1 - 1.2e-33 115.1 0.3 0.00067 19.8 0.0 7.3 7 0 0 7 7 7 7 PDZ domain GRASP55_65 PF04495.12 138535.2_45729001_1 - 0.02 15.1 0.0 6.9 6.9 0.0 4.1 4 2 1 6 6 6 0 GRASP55/65 PDZ-like domain PDCD2_C PF04194.11 031638.1_45723001_3 - 2.6e-44 151.1 0.1 2.3e-42 144.8 0.0 2.4 2 0 0 2 2 2 2 Programmed cell death protein 2, C-terminal putative domain zf-MYND PF01753.16 031638.1_45723001_3 - 6e-08 32.5 14.8 6e-08 32.5 14.8 2.5 2 0 0 2 2 2 1 MYND finger Clat_adaptor_s PF01217.18 001127531.2_45724001_3 - 2.3e-59 199.2 1.9 3.3e-59 198.7 1.9 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DnaJ PF00226.29 001159884.1_32924001_1 - 1.9e-26 91.8 5.0 2.9e-26 91.3 5.0 1.3 1 0 0 1 1 1 1 DnaJ domain UIM PF02809.18 001159884.1_32924001_1 - 0.0011 18.6 8.5 0.0015 18.2 4.0 2.6 2 0 0 2 2 2 1 Ubiquitin interaction motif Citrate_bind PF16114.3 016987.2_45729001_2 - 3.7e-92 306.6 0.1 6.3e-92 305.8 0.1 1.4 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding Citrate_synt PF00285.19 016987.2_45729001_2 - 2.9e-22 79.1 0.0 2.1e-19 69.7 0.0 2.9 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain Ligase_CoA PF00549.17 016987.2_45729001_2 - 1e-13 51.2 0.0 1.9e-13 50.3 0.0 1.5 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.17 016987.2_45729001_2 - 2.3e-12 47.3 0.0 4.7e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 CoA binding domain ATP-grasp_2 PF08442.8 016987.2_45729001_2 - 5.5e-05 22.7 0.0 0.0001 21.8 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.4 016987.2_45729001_2 - 0.00092 18.9 0.0 0.0027 17.4 0.0 1.8 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain FKBP_C PF00254.26 001106736.2_45723001_3 - 7.6e-31 106.2 0.0 1.3e-30 105.4 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Sec23_trunk PF04811.13 001135345.1_43528001_3 - 1.9e-79 266.6 0.0 2.6e-79 266.1 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.10 001135345.1_43528001_3 - 3.5e-33 114.1 0.0 7e-33 113.1 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.13 001135345.1_43528001_3 - 6.2e-27 93.3 0.1 1.5e-26 92.1 0.1 1.7 2 0 0 2 2 2 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.13 001135345.1_43528001_3 - 2.3e-15 56.2 6.5 4.6e-15 55.3 6.5 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.20 001135345.1_43528001_3 - 1.5e-14 53.5 0.0 3.3e-14 52.4 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat APP_E2 PF12925.5 001135345.1_43528001_3 - 0.044 13.4 0.0 0.084 12.4 0.0 1.4 1 0 0 1 1 1 0 E2 domain of amyloid precursor protein UPF0544 PF15749.3 001109030.2_45723001_2 - 1.2e-29 103.0 4.1 1.2e-29 103.0 4.1 1.9 3 0 0 3 3 3 1 Uncharacterised protein family UPF0544 Smoothelin PF12510.6 001013049.2_45727001_2 - 2.9e-48 161.6 27.8 8.4e-21 73.6 1.9 3.7 3 0 0 3 3 3 3 Smoothelin cytoskeleton protein CH PF00307.29 001013049.2_45727001_2 - 3.4e-24 85.0 0.0 3.2e-22 78.6 0.0 2.5 2 0 0 2 2 2 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 001013049.2_45727001_2 - 1.5e-05 24.6 0.0 2.9e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 CAMSAP CH domain Peptidase_M3_N PF08439.8 001013049.2_45727001_2 - 4.3 7.6 8.8 3.8 7.7 0.8 3.4 3 0 0 3 3 3 0 Oligopeptidase F Pannexin_like PF12534.6 015350.2_26229001_1 - 9.9e-127 422.7 8.7 1.5e-126 422.1 8.7 1.3 1 0 0 1 1 1 1 Pannexin-like TM region of LRRC8 LRR_8 PF13855.4 015350.2_26229001_1 - 3.1e-27 94.0 42.2 1.7e-08 34.0 6.6 6.5 4 1 2 6 6 6 6 Leucine rich repeat LRR_4 PF12799.5 015350.2_26229001_1 - 5.7e-17 61.4 52.1 0.0012 19.1 0.3 8.5 5 1 4 10 10 10 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 015350.2_26229001_1 - 1e-06 28.2 17.4 0.0081 15.5 2.2 3.4 1 1 2 3 3 3 3 Leucine-rich repeat RIIa PF02197.15 001143893.1_45725001_3 - 5.9e-11 41.7 1.0 7.4e-09 35.0 0.0 2.9 4 0 0 4 4 4 2 Regulatory subunit of type II PKA R-subunit G-patch PF01585.21 032460.2_32923001_2 - 2.8e-13 49.4 0.5 6.1e-13 48.3 0.5 1.6 1 0 0 1 1 1 1 G-patch domain Ank_2 PF12796.5 032460.2_32923001_2 - 4.8e-06 26.9 0.0 8.2e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 032460.2_32923001_2 - 5.3e-05 23.3 0.8 0.0026 17.9 0.7 2.6 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.4 032460.2_32923001_2 - 8.4e-05 22.9 0.0 0.00021 21.7 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 032460.2_32923001_2 - 0.00021 21.4 0.0 0.0055 17.0 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat SPT6_acidic PF14632.4 032460.2_32923001_2 - 0.15 12.5 1.6 0.18 12.2 0.1 1.8 2 0 0 2 2 2 0 Acidic N-terminal SPT6 Ank PF00023.28 032460.2_32923001_2 - 0.16 12.3 0.1 1.1 9.7 0.0 2.2 2 0 0 2 2 2 0 Ankyrin repeat G-patch_2 PF12656.5 032460.2_32923001_2 - 0.2 11.6 0.2 0.2 11.6 0.2 1.9 2 0 0 2 2 2 0 G-patch domain zf-DBF PF07535.10 032460.2_32923001_2 - 0.23 11.4 1.1 0.38 10.8 1.1 1.2 1 0 0 1 1 1 0 DBF zinc finger DUF2363 PF10155.7 001108794.2_45724001_1 - 5.4e-55 184.8 6.3 7.9e-55 184.2 6.3 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2363) BTB PF00651.29 001134447.1_45724001_3 - 2.9e-32 111.0 0.9 7.6e-32 109.7 0.2 1.9 1 1 1 2 2 2 1 BTB/POZ domain MATH PF00917.24 001134447.1_45724001_3 - 6.4e-06 26.1 0.0 1.3e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 MATH domain Sushi PF00084.18 001134538.1_45728001_3 - 2.9e-45 152.5 23.4 3.8e-11 43.3 0.9 5.5 5 0 0 5 5 5 5 Sushi repeat (SCR repeat) CUB PF00431.18 001134538.1_45728001_3 - 4e-38 130.0 0.0 3.8e-16 59.3 0.0 3.5 3 0 0 3 3 3 3 CUB domain CUB_2 PF02408.18 001134538.1_45728001_3 - 6.3e-07 29.1 0.0 0.69 9.6 0.0 3.4 3 0 0 3 3 3 3 CUB-like domain BEX PF04538.10 001012978.2_26222001_3 - 4.2e-23 82.2 0.8 5.5e-23 81.8 0.8 1.2 1 0 0 1 1 1 1 Brain expressed X-linked like family Pox_A_type_inc PF04508.10 001012978.2_26222001_3 - 0.82 9.5 4.7 1.6 8.6 4.7 1.4 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat E1-E2_ATPase PF00122.18 001133855.1_43528001_2 - 9.5e-58 195.0 1.9 9.5e-58 195.0 1.9 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 001133855.1_43528001_2 - 6.2e-44 149.7 0.2 6.2e-44 149.7 0.2 2.1 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 001133855.1_43528001_2 - 3.6e-23 81.3 0.0 9.4e-23 80.0 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 001133855.1_43528001_2 - 6.7e-19 68.9 0.0 1.3e-09 38.5 0.0 3.1 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 001133855.1_43528001_2 - 6.9e-18 63.9 0.0 1.3e-17 63.1 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 001133855.1_43528001_2 - 0.00091 18.9 0.5 0.00091 18.9 0.5 3.4 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Tetraspannin PF00335.18 001133855.1_43528001_2 - 0.17 11.6 4.1 1.4 8.6 0.4 2.8 3 0 0 3 3 3 0 Tetraspanin family Cnd1_N PF12922.5 001133855.1_43528001_2 - 5.8 6.6 12.3 13 5.4 12.3 1.5 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term EF-hand_7 PF13499.4 001012202.2_45729001_3 - 4.4e-23 81.4 2.9 1.8e-21 76.3 0.3 3.4 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.30 001012202.2_45729001_3 - 5e-05 22.4 0.3 0.07 12.6 0.1 4.1 4 0 0 4 4 4 1 EF hand EF-hand_5 PF13202.4 001012202.2_45729001_3 - 0.00017 20.9 0.0 0.0037 16.6 0.0 3.0 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.4 001012202.2_45729001_3 - 0.00025 20.6 0.6 0.024 14.4 0.0 4.1 5 0 0 5 5 5 1 EF-hand domain ADP_PFK_GK PF04587.13 001100723.1_45726001_3 - 2.1e-136 454.7 0.0 2.5e-136 454.5 0.0 1.0 1 0 0 1 1 1 1 ADP-specific Phosphofructokinase/Glucokinase conserved region F-box PF00646.31 001008777.2_26225001_3 - 0.00018 21.2 0.0 0.00071 19.3 0.0 2.1 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.5 001008777.2_26225001_3 - 0.036 13.8 0.6 0.098 12.4 0.0 2.1 2 0 0 2 2 2 0 F-box-like Ribosomal_S9 PF00380.17 001100549.1_45723001_1 - 2.2e-37 128.1 0.0 4.1e-37 127.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S9/S16 PID PF00640.21 001013171.2_45726001_1 - 2.4e-31 108.5 0.5 3.5e-31 108.0 0.5 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 001013171.2_45726001_1 - 2.5e-11 43.7 0.1 4.1e-11 43.0 0.1 1.3 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID_2 PF14719.4 001013171.2_45726001_1 - 1.4e-05 24.9 0.0 2e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Ax_dynein_light PF10211.7 001013171.2_45726001_1 - 0.004 17.0 0.2 0.0063 16.3 0.2 1.2 1 0 0 1 1 1 1 Axonemal dynein light chain bZIP_2 PF07716.13 001013171.2_45726001_1 - 0.0071 16.3 3.1 0.013 15.4 3.1 1.4 1 0 0 1 1 1 1 Basic region leucine zipper DivIC PF04977.13 001013171.2_45726001_1 - 0.049 13.3 2.1 0.092 12.4 2.1 1.3 1 0 0 1 1 1 0 Septum formation initiator Cnn_1N PF07989.9 001013171.2_45726001_1 - 0.052 13.5 0.2 0.098 12.7 0.2 1.3 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 DEAD PF00270.27 001144834.1_39725001_3 - 1.3e-45 155.2 0.0 2.9e-45 154.0 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase P68HR PF08061.9 001144834.1_39725001_3 - 1.3e-33 114.7 24.1 8.6e-18 64.1 2.4 3.2 3 0 0 3 3 3 2 P68HR (NUC004) repeat Helicase_C PF00271.29 001144834.1_39725001_3 - 5.2e-31 107.2 0.0 1.2e-30 105.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 001144834.1_39725001_3 - 0.0042 17.0 0.0 0.049 13.5 0.0 2.5 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.3 001144834.1_39725001_3 - 0.0059 15.7 0.0 0.01 15.0 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Ras PF00071.20 001106461.1_45723001_1 - 5.2e-57 191.8 0.0 6.4e-57 191.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001106461.1_45723001_1 - 8.4e-23 80.7 0.0 1.2e-22 80.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001106461.1_45723001_1 - 2.3e-09 36.8 0.0 3.8e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001106461.1_45723001_1 - 0.00072 19.0 0.0 0.0012 18.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 001106461.1_45723001_1 - 0.061 12.5 0.0 0.089 12.0 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.8 001106461.1_45723001_1 - 0.18 11.1 0.0 0.27 10.5 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit GLTP PF08718.9 001114758.1_39722001_3 - 8.1e-44 149.4 0.0 1e-43 149.0 0.0 1.1 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) RtcB PF01139.15 001168775.1_40424001_1 - 3.7e-146 487.4 0.4 4.3e-146 487.2 0.4 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB Mito_fiss_reg PF05308.9 001134850.1_45727001_1 - 0.87 9.5 3.7 1.5 8.7 3.7 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator zf-CSL PF05207.11 001134850.1_45727001_3 - 2.6e-23 81.4 1.8 5.1e-23 80.4 1.8 1.5 1 0 0 1 1 1 1 CSL zinc finger HSP20 PF00011.19 031607.1_45724001_1 - 7e-14 51.7 0.0 2.2e-13 50.1 0.0 1.7 2 0 0 2 2 2 1 Hsp20/alpha crystallin family Fez1 PF06818.13 001111115.1_45726001_2 - 0.0023 18.3 3.5 0.0023 18.3 3.5 2.2 2 0 0 2 2 2 1 Fez1 IFT57 PF10498.7 001111115.1_45726001_2 - 0.005 15.7 11.7 0.0076 15.1 11.7 1.1 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Rab5-bind PF09311.9 001111115.1_45726001_2 - 0.016 14.5 9.6 0.025 13.8 9.6 1.2 1 0 0 1 1 1 0 Rabaptin-like protein Spc7 PF08317.9 001111115.1_45726001_2 - 0.031 13.0 11.4 0.046 12.5 11.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3584 PF12128.6 001111115.1_45726001_2 - 0.035 11.5 12.7 0.048 11.1 12.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) FlgN PF05130.10 001111115.1_45726001_2 - 0.06 13.7 6.6 0.13 12.6 6.6 1.5 1 0 0 1 1 1 0 FlgN protein Leu_zip PF15294.4 001111115.1_45726001_2 - 0.066 12.6 9.6 0.1 11.9 9.6 1.2 1 0 0 1 1 1 0 Leucine zipper DUF812 PF05667.9 001111115.1_45726001_2 - 0.2 10.4 8.7 0.34 9.6 8.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) TBPIP PF07106.11 001111115.1_45726001_2 - 0.29 10.8 8.7 1.1 8.9 8.6 1.9 2 1 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) CorA PF01544.16 001111115.1_45726001_2 - 0.34 10.1 4.0 0.59 9.3 4.0 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein ADIP PF11559.6 001111115.1_45726001_2 - 0.42 10.5 11.1 0.73 9.8 10.5 1.7 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding IncA PF04156.12 001111115.1_45726001_2 - 0.6 9.7 17.3 0.54 9.9 15.5 1.7 1 1 0 1 1 1 0 IncA protein V_ATPase_I PF01496.17 001111115.1_45726001_2 - 0.69 7.6 3.5 0.97 7.1 3.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HAUS-augmin3 PF14932.4 001111115.1_45726001_2 - 0.92 8.8 13.1 1.8 7.9 13.1 1.5 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF1664 PF07889.10 001111115.1_45726001_2 - 0.96 9.3 5.3 0.72 9.7 2.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.7 001111115.1_45726001_2 - 1.2 9.3 7.3 0.37 11.0 3.5 1.9 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF342 PF03961.11 001111115.1_45726001_2 - 2.4 6.5 7.1 3.9 5.8 7.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Mnd1 PF03962.13 001111115.1_45726001_2 - 3.3 7.4 11.3 6 6.6 11.3 1.4 1 0 0 1 1 1 0 Mnd1 family DUF2730 PF10805.6 001111115.1_45726001_2 - 3.8 7.5 5.3 1.1 9.2 2.3 1.6 2 0 0 2 2 1 0 Protein of unknown function (DUF2730) Exonuc_VII_L PF02601.13 001111115.1_45726001_2 - 6.6 6.1 8.0 11 5.4 8.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF724 PF05266.12 001111115.1_45726001_2 - 8.5 6.0 8.6 18 5.0 8.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF724) PseudoU_synth_1 PF01416.18 001108134.2_45724001_3 - 7.9e-34 116.2 0.0 6.4e-32 110.1 0.0 2.5 2 0 0 2 2 2 1 tRNA pseudouridine synthase Shugoshin_N PF07558.9 001108134.2_45724001_3 - 0.068 12.9 1.6 0.22 11.3 1.5 1.9 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region WD40_alt PF14077.4 001108134.2_45724001_3 - 0.35 10.6 6.2 0.081 12.7 2.5 1.8 2 0 0 2 2 2 0 Alternative WD40 repeat motif Brix PF04427.16 001100794.1_45723001_3 - 1.7e-26 93.4 0.2 2.5e-26 92.8 0.2 1.3 1 0 0 1 1 1 1 Brix domain Peptidase_S30 PF01577.14 001100794.1_45723001_3 - 0.025 14.1 0.6 0.044 13.3 0.6 1.3 1 0 0 1 1 1 0 Potyvirus P1 protease Amino_oxidase PF01593.22 001130098.1_45727001_1 - 3.1e-135 451.8 0.0 1.7e-134 449.3 0.0 1.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase SWIRM PF04433.15 001130098.1_45727001_1 - 4.8e-17 61.9 0.3 2e-16 60.0 0.0 2.2 3 0 0 3 3 1 1 SWIRM domain NAD_binding_8 PF13450.4 001130098.1_45727001_1 - 5.7e-14 52.0 0.7 1.5e-13 50.6 0.7 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 001130098.1_45727001_1 - 1.1e-07 31.7 0.0 3.7e-07 30.0 0.0 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.12 001130098.1_45727001_1 - 3.7e-06 26.3 0.1 1.6e-05 24.2 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.25 001130098.1_45727001_1 - 1.2e-05 25.7 0.3 0.00012 22.4 0.1 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.19 001130098.1_45727001_1 - 2.5e-05 23.6 0.3 6.6e-05 22.2 0.3 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.22 001130098.1_45727001_1 - 0.00016 20.7 1.3 0.00021 20.4 0.4 1.6 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.12 001130098.1_45727001_1 - 0.00096 17.8 0.2 0.00096 17.8 0.2 2.0 1 1 1 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.17 001130098.1_45727001_1 - 0.0012 18.1 0.4 0.0021 17.3 0.4 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.5 001130098.1_45727001_1 - 0.0013 18.0 1.6 0.0013 18.0 1.6 2.1 2 1 0 3 3 2 1 FAD dependent oxidoreductase Thi4 PF01946.15 001130098.1_45727001_1 - 0.0056 15.8 0.2 0.01 15.0 0.2 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.4 001130098.1_45727001_1 - 0.014 14.5 0.1 0.096 11.8 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.20 001130098.1_45727001_1 - 0.017 14.1 5.1 0.025 13.6 0.2 2.2 1 1 0 2 2 2 0 Glucose inhibited division protein A DUF1917 PF08939.8 001130098.1_45727001_1 - 0.018 14.8 0.2 0.037 13.7 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1917) 2-Hacid_dh_C PF02826.17 001130098.1_45727001_1 - 0.065 12.4 0.2 0.19 10.9 0.1 1.8 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain MutS_IV PF05190.16 001130098.1_45727001_1 - 0.069 13.4 3.2 0.48 10.6 0.6 2.5 2 0 0 2 2 2 0 MutS family domain IV Lycopene_cycl PF05834.10 001130098.1_45727001_1 - 0.073 12.0 0.1 0.13 11.1 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Snapin_Pallidin PF14712.4 001130098.1_45727001_1 - 1.1 9.6 7.7 11 6.4 7.7 2.3 1 1 0 1 1 1 0 Snapin/Pallidin DUF4298 PF14131.4 001130098.1_45727001_1 - 1.3 8.9 7.2 1.3 8.9 0.9 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4298) DASH_Dad3 PF08656.8 001130098.1_45727001_1 - 1.4 9.0 4.0 10 6.2 0.1 2.8 3 0 0 3 3 2 0 DASH complex subunit Dad3 DivIC PF04977.13 001130098.1_45727001_1 - 1.4 8.6 7.4 22 4.8 0.1 2.7 2 0 0 2 2 2 0 Septum formation initiator IncA PF04156.12 001130098.1_45727001_1 - 7.9 6.1 14.9 0.95 9.1 9.6 2.1 2 0 0 2 2 2 0 IncA protein Arfaptin PF06456.11 001131379.1_43524001_2 - 8.3e-85 283.9 2.1 1.3e-84 283.2 2.1 1.3 1 0 0 1 1 1 1 Arfaptin-like domain PDZ PF00595.22 001131379.1_43524001_2 - 1.9e-10 40.8 0.2 3.3e-10 40.1 0.2 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001131379.1_43524001_2 - 1e-05 25.6 0.1 3.8e-05 23.8 0.0 2.0 2 0 0 2 2 2 1 PDZ domain BAR PF03114.16 001131379.1_43524001_2 - 1.2e-05 24.9 1.8 9.8e-05 22.0 1.8 2.0 1 1 0 1 1 1 1 BAR domain BAR_3 PF16746.3 001131379.1_43524001_2 - 0.00069 19.2 1.6 0.48 9.9 0.4 2.2 2 0 0 2 2 2 2 BAR domain of APPL family DALR_1 PF05746.13 001131379.1_43524001_2 - 0.026 14.6 0.1 0.29 11.2 0.1 2.2 2 0 0 2 2 2 0 DALR anticodon binding domain GRASP55_65 PF04495.12 001131379.1_43524001_2 - 0.16 12.1 0.0 1.4 9.1 0.0 2.1 2 0 0 2 2 2 0 GRASP55/65 PDZ-like domain DHFR_1 PF00186.17 176815.4_26228001_2 - 1.5e-28 99.4 0.0 2.1e-28 98.9 0.0 1.2 1 0 0 1 1 1 1 Dihydrofolate reductase Calx-beta PF03160.12 001173019.1_09927001_3 - 5.1e-65 215.8 11.4 7.3e-36 122.2 1.7 2.7 3 0 0 3 3 3 2 Calx-beta domain Na_Ca_ex PF01699.22 001173019.1_09927001_3 - 7.7e-63 210.9 30.2 1.7e-35 122.1 11.3 2.4 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Na_Ca_ex_C PF16494.3 001173019.1_09927001_3 - 5.9e-51 172.1 6.0 1.1e-50 171.3 6.0 1.4 1 0 0 1 1 1 1 C-terminal extension of sodium/calcium exchanger domain DnaG_DnaB_bind PF08278.9 001173019.1_09927001_3 - 0.042 14.3 2.3 0.1 13.0 2.3 1.6 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding Plectin PF00681.18 001164305.1_45729001_1 - 1.6e-296 955.9 38.0 8.4e-21 73.4 0.0 29.6 26 5 5 31 31 31 25 Plectin repeat CH PF00307.29 001164305.1_45729001_1 - 2.4e-47 159.5 0.2 1.6e-22 79.6 0.2 3.2 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.6 001164305.1_45729001_1 - 2.9e-05 23.7 0.1 0.016 14.9 0.0 2.7 2 0 0 2 2 2 2 CAMSAP CH domain PhoQ_Sensor PF08918.8 001164305.1_45729001_1 - 0.22 11.2 0.8 1.1 9.0 0.3 2.5 1 1 0 1 1 1 0 PhoQ Sensor Imm70 PF15601.4 001164305.1_45729001_1 - 0.84 9.0 3.9 0.88 9.0 0.0 3.2 3 0 0 3 3 3 0 Immunity protein 70 Glyco_hydro_56 PF01630.16 001173021.2_09925001_3 - 1.6e-132 441.4 0.0 2.1e-132 441.1 0.0 1.1 1 0 0 1 1 1 1 Hyaluronidase Exo_endo_phos PF03372.21 001108923.2_45726001_1 - 0.00043 20.4 0.0 0.00077 19.6 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Glyco_hydro_cc PF11790.6 001108923.2_45726001_1 - 0.0047 16.4 0.8 0.96 8.8 0.1 2.2 2 0 0 2 2 2 2 Glycosyl hydrolase catalytic core OLF PF02191.14 001108923.2_45726001_1 - 0.031 13.7 0.9 0.053 13.0 0.9 1.3 1 0 0 1 1 1 0 Olfactomedin-like domain Sortilin-Vps10 PF15902.3 053519.1_45729001_1 - 1.7e-113 379.7 0.1 2.4e-113 379.1 0.1 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Ldl_recept_a PF00057.16 053519.1_45729001_1 - 4.7e-113 369.0 202.7 1.6e-13 50.4 15.8 12.4 11 1 1 12 12 12 11 Low-density lipoprotein receptor domain class A Sortilin_C PF15901.3 053519.1_45729001_1 - 1e-40 139.7 0.1 1e-40 139.7 0.1 4.9 3 1 1 4 4 1 1 Sortilin, neurotensin receptor 3, C-terminal fn3 PF00041.19 053519.1_45729001_1 - 3.5e-37 126.5 8.5 4.8e-09 36.3 0.1 6.1 6 0 0 6 6 6 5 Fibronectin type III domain Ldl_recept_b PF00058.15 053519.1_45729001_1 - 3.7e-23 81.6 10.7 4e-06 27.1 0.2 5.9 6 0 0 6 6 6 4 Low-density lipoprotein receptor repeat class B Pur_ac_phosph_N PF16656.3 053519.1_45729001_1 - 9.6e-06 26.0 11.6 0.41 11.1 0.0 5.6 6 0 0 6 6 6 2 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 053519.1_45729001_1 - 0.0028 17.8 13.0 0.22 11.7 1.1 5.7 6 0 0 6 6 6 1 Interferon-alpha/beta receptor, fibronectin type III DUF4945 PF16303.3 053519.1_45729001_1 - 0.015 15.1 1.0 0.28 11.0 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4945) Tissue_fac PF01108.15 053519.1_45729001_1 - 0.037 13.7 5.5 6.2 6.6 2.1 4.5 3 1 1 4 4 4 0 Tissue factor BNR_6 PF15899.3 053519.1_45729001_1 - 0.088 12.8 7.9 1.8 8.7 0.1 3.6 3 0 0 3 3 3 0 BNR-Asp box repeat BNR PF02012.18 053519.1_45729001_1 - 2.8 8.2 23.7 3 8.1 0.2 6.1 6 0 0 6 6 6 0 BNR/Asp-box repeat KRTDAP PF15200.4 001173357.1_45725001_3 - 0.021 14.4 6.9 0.1 12.3 0.6 2.4 1 1 1 2 2 2 0 Keratinocyte differentiation-associated EF-hand_1 PF00036.30 001195640.1_37923001_1 - 3.1e-41 135.7 9.6 1.8e-09 36.3 0.4 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 001195640.1_37923001_1 - 2.5e-35 120.6 2.7 3.5e-18 65.7 0.7 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 001195640.1_37923001_1 - 7.3e-33 112.0 9.4 6.5e-15 54.5 0.3 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.4 001195640.1_37923001_1 - 4.6e-29 97.7 5.5 4.7e-09 35.3 0.1 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.4 001195640.1_37923001_1 - 1.2e-25 87.7 6.9 3.7e-06 26.1 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.4 001195640.1_37923001_1 - 2.7e-14 53.1 0.2 1.5e-08 34.7 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 001195640.1_37923001_1 - 8.1e-09 35.2 0.2 0.00035 20.4 0.1 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 001195640.1_37923001_1 - 9.5e-07 29.0 0.0 0.025 14.8 0.0 2.3 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.9 001195640.1_37923001_1 - 6.8e-05 23.6 0.0 0.007 17.1 0.0 2.2 1 1 1 2 2 2 1 EF-hand domain EFhand_Ca_insen PF08726.8 001195640.1_37923001_1 - 0.00023 21.0 0.7 0.00052 19.9 0.1 1.9 2 0 0 2 2 2 1 Ca2+ insensitive EF hand UPF0154 PF03672.11 001195640.1_37923001_1 - 0.00045 20.0 0.0 0.18 11.7 0.0 2.8 2 1 1 3 3 3 1 Uncharacterised protein family (UPF0154) DUF1103 PF06513.9 001195640.1_37923001_1 - 0.0068 15.9 1.2 0.0091 15.5 1.2 1.1 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) DUF4497 PF14924.4 001195640.1_37923001_1 - 0.012 16.0 0.0 5.1 7.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4497) Caleosin PF05042.11 001195640.1_37923001_1 - 0.039 13.7 0.3 2.4 7.9 0.0 2.9 1 1 3 4 4 4 0 Caleosin related protein DUF3349 PF11829.6 001195640.1_37923001_1 - 0.041 14.5 0.3 7.2 7.3 0.0 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) RNA_pol_Rpb4 PF03874.14 001195640.1_37923001_1 - 0.054 13.7 0.2 6.8 6.9 0.1 2.4 2 0 0 2 2 2 0 RNA polymerase Rpb4 TerB PF05099.11 001195640.1_37923001_1 - 0.067 13.0 0.4 4.1 7.2 0.0 2.2 1 1 1 2 2 2 0 Tellurite resistance protein TerB GPHH PF16905.3 001195640.1_37923001_1 - 0.13 11.9 0.0 0.74 9.5 0.0 2.2 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated DUF2267 PF10025.7 001195640.1_37923001_1 - 0.17 12.1 0.0 0.41 10.8 0.0 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) SurA_N_2 PF13623.4 001195640.1_37923001_1 - 0.19 11.5 0.7 2.6 7.7 0.1 2.1 1 1 1 2 2 2 0 SurA N-terminal domain Med25_VWA PF11265.6 001170426.1_45725001_1 - 1.1e-87 293.2 0.0 1.5e-87 292.8 0.0 1.2 1 0 0 1 1 1 1 Mediator complex subunit 25 von Willebrand factor type A Med25 PF11232.6 001170426.1_45725001_1 - 3.3e-61 205.6 0.1 5.3e-61 204.9 0.1 1.3 1 0 0 1 1 1 1 Mediator complex subunit 25 PTOV activation and synapsin 2 Med25_SD1 PF11235.6 001170426.1_45725001_1 - 7.2e-57 192.2 48.9 7.2e-57 192.2 48.9 3.7 2 1 1 3 3 3 1 Mediator complex subunit 25 synapsin 1 Med25_NR-box PF11244.6 001170426.1_45725001_1 - 4.1e-39 132.8 19.1 4.1e-39 132.8 19.1 5.1 3 2 2 5 5 5 1 Mediator complex subunit 25 C-terminal NR box-containing VWC PF00093.16 001169103.1_45729001_3 - 8.2e-37 125.2 129.3 1.1e-10 41.5 14.5 15.7 9 2 6 15 15 15 6 von Willebrand factor type C domain Antistasin PF02822.12 001169103.1_45729001_3 - 7e-17 61.6 58.8 1.2e-06 28.9 9.2 14.8 17 1 0 17 17 17 4 Antistasin family IGFBP PF00219.16 001169103.1_45729001_3 - 4e-07 30.4 21.6 4e-07 30.4 21.6 15.5 9 5 3 12 12 12 1 Insulin-like growth factor binding protein Amnionless PF14828.4 001169103.1_45729001_3 - 0.001 17.9 11.8 0.001 17.9 11.8 9.0 10 1 0 10 10 10 5 Amnionless Iso_dh PF00180.18 001145872.1_06524001_2 - 2e-75 254.0 0.2 2.5e-75 253.7 0.2 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase AAA_3 PF07726.9 001145872.1_06524001_2 - 0.027 14.2 0.0 0.045 13.5 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RIO1 PF01163.20 001100511.1_45725001_2 - 3.2e-76 255.0 0.2 1e-75 253.4 0.2 1.9 1 0 0 1 1 1 1 RIO1 family APH PF01636.21 001100511.1_45725001_2 - 0.00034 20.5 0.0 0.069 12.9 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Y_phosphatase PF00102.25 017269.2_45729001_1 - 2e-82 276.2 0.5 3.3e-82 275.5 0.5 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.19 017269.2_45729001_1 - 2.4e-38 130.2 27.6 3.5e-06 27.1 1.4 9.6 9 1 1 10 10 10 7 Fibronectin type III domain DUF2369 PF10179.7 017269.2_45729001_1 - 1.2e-08 35.1 1.5 0.13 12.7 0.0 5.6 6 0 0 6 6 6 3 Uncharacterised conserved protein (DUF2369) Pur_ac_phosph_N PF16656.3 017269.2_45729001_1 - 2.1e-07 31.3 17.3 1 9.8 0.1 6.9 3 1 2 5 5 5 4 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.3 017269.2_45729001_1 - 1.4e-05 25.0 4.2 0.03 14.3 0.2 4.5 4 0 0 4 4 4 1 Fibronectin type III domain Interfer-bind PF09294.8 017269.2_45729001_1 - 3.9e-05 23.8 0.4 17 5.7 0.0 5.8 4 1 2 6 6 6 1 Interferon-alpha/beta receptor, fibronectin type III DSPc PF00782.18 017269.2_45729001_1 - 0.0028 17.3 0.0 0.0063 16.2 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 017269.2_45729001_1 - 0.0047 16.8 0.0 0.0086 15.9 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.4 017269.2_45729001_1 - 0.011 15.7 0.0 0.022 14.8 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate E1-E2_ATPase PF00122.18 001163074.1_37927001_1 - 1.1e-57 194.8 1.8 1.1e-57 194.8 1.8 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 001163074.1_37927001_1 - 1.3e-44 152.0 0.3 1.3e-44 152.0 0.3 2.1 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 001163074.1_37927001_1 - 1.1e-23 83.0 0.0 2.4e-23 81.9 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 001163074.1_37927001_1 - 1.1e-18 68.2 0.2 1.7e-09 38.2 0.0 2.9 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 001163074.1_37927001_1 - 3e-18 65.1 0.0 5.5e-18 64.3 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 001163074.1_37927001_1 - 7e-06 25.8 0.9 0.00086 19.0 0.5 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase DUF1290 PF06947.10 001163074.1_37927001_1 - 0.053 13.5 0.8 0.36 10.8 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1290) HMG14_17 PF01101.16 001201353.1_45722001_3 - 5.1e-23 81.7 25.9 5.1e-23 81.7 25.9 1.5 2 0 0 2 2 2 1 HMG14 and HMG17 TT_ORF2 PF02957.13 001201353.1_45722001_3 - 0.94 10.3 8.8 1.6 9.5 8.8 1.4 1 0 0 1 1 1 0 TT viral ORF2 CAF1C_H4-bd PF12265.6 001131214.1_43524001_3 - 6.2e-28 96.7 0.4 3e-27 94.5 0.1 2.2 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.30 001131214.1_43524001_3 - 1.1e-25 89.3 14.7 4.8e-07 30.3 0.0 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001131214.1_43524001_3 - 0.0002 21.4 0.8 0.022 14.9 0.0 3.3 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 001131214.1_43524001_3 - 0.00049 19.9 0.5 0.033 13.9 0.0 2.9 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Capsid_NCLDV PF04451.10 001131214.1_43524001_3 - 0.12 12.0 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Large eukaryotic DNA virus major capsid protein SCO1-SenC PF02630.12 001173374.1_45724001_2 - 1.6e-45 154.9 0.0 2.2e-45 154.4 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.19 001173374.1_45724001_2 - 7.1e-06 25.8 0.0 1.2e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.4 001173374.1_45724001_2 - 0.025 14.8 0.0 0.044 14.0 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like C1-set PF07654.13 001009066.2_39722001_2 - 2.8e-22 78.9 0.1 3.9e-22 78.4 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001009066.2_39722001_2 - 0.0019 18.6 0.0 0.0031 18.0 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001009066.2_39722001_2 - 0.024 14.6 0.0 0.036 14.0 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin I-set domain zf-FCS PF06467.12 201599.2_26229001_3 - 1.3e-65 216.9 127.2 1e-09 38.0 3.0 11.0 11 0 0 11 11 11 10 MYM-type Zinc finger with FCS sequence motif DUF3504 PF12012.6 201599.2_26229001_3 - 2.1e-65 219.4 0.3 5.1e-65 218.2 0.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3504) YHS PF04945.11 201599.2_26229001_3 - 0.00047 20.1 41.9 0.22 11.5 0.1 9.5 9 0 0 9 9 9 3 YHS domain NosL PF05573.10 201599.2_26229001_3 - 0.0039 17.2 2.5 4.8 7.2 0.1 3.6 3 0 0 3 3 3 2 NosL Arc_trans_TRASH PF08394.8 201599.2_26229001_3 - 0.0063 16.7 3.9 0.0063 16.7 3.9 7.3 5 2 0 5 5 5 2 Archaeal TRASH domain Na_K-ATPase PF00287.16 001172917.1_09923001_2 - 5.5e-98 327.5 0.2 7.2e-98 327.1 0.2 1.0 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain RRM_1 PF00076.20 001009720.2_45724001_2 - 1.4e-21 75.9 0.0 2.1e-21 75.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 001009720.2_45724001_2 - 0.0076 16.1 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Ste5 PF11610.6 001009720.2_45724001_3 - 1.8 8.4 5.1 0.86 9.4 0.3 2.3 2 0 0 2 2 2 0 Scaffold protein Ste5, Fus3-binding region HLH PF00010.24 152414.4_26227001_2 - 2.8e-13 49.5 1.1 2.8e-13 49.5 1.1 2.2 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain E1-E2_ATPase PF00122.18 001172916.1_09929001_1 - 5.4e-55 186.0 5.0 5.4e-55 186.0 5.0 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 001172916.1_09929001_1 - 3.8e-39 134.1 2.5 3.8e-39 134.1 2.5 2.7 3 0 0 3 3 3 2 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 001172916.1_09929001_1 - 3.5e-25 87.8 0.0 6.6e-25 86.9 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 001172916.1_09929001_1 - 2.9e-19 70.1 0.0 9e-11 42.3 0.0 2.6 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 001172916.1_09929001_1 - 2.1e-16 59.2 0.0 3.7e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 001172916.1_09929001_1 - 1e-06 28.6 4.0 0.00047 19.8 1.4 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.5 001172916.1_09929001_1 - 0.12 12.7 0.1 0.58 10.4 0.1 2.0 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase PAX PF00292.16 053710.1_45725001_1 - 5.7e-75 249.1 0.9 8.6e-75 248.5 0.9 1.3 1 0 0 1 1 1 1 'Paired box' domain Pax7 PF12360.6 053710.1_45725001_1 - 1.8e-25 88.7 7.6 3.4e-25 87.8 7.6 1.5 1 0 0 1 1 1 1 Paired box protein 7 Homeobox PF00046.27 053710.1_45725001_1 - 1.4e-22 79.1 6.7 2.4e-22 78.3 6.7 1.4 1 0 0 1 1 1 1 Homeobox domain HTH_32 PF13565.4 053710.1_45725001_1 - 0.00037 20.9 8.9 0.0017 18.8 0.0 3.6 3 1 1 4 4 4 1 Homeodomain-like domain Homeobox_KN PF05920.9 053710.1_45725001_1 - 0.00038 20.2 0.6 0.00096 18.9 0.6 1.7 1 0 0 1 1 1 1 Homeobox KN domain HTH_23 PF13384.4 053710.1_45725001_1 - 0.00049 19.7 2.0 0.0041 16.8 0.1 2.5 2 0 0 2 2 2 1 Homeodomain-like domain GIY-YIG PF01541.22 178044.2_26222001_3 - 7.3e-09 35.7 0.0 2.1e-08 34.2 0.0 1.7 2 0 0 2 2 2 1 GIY-YIG catalytic domain FANCL_C PF11793.6 178044.2_26222001_3 - 0.052 13.6 2.0 0.1 12.7 2.0 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain Acetyltransf_13 PF13880.4 001126299.2_45728001_3 - 1.1e-29 102.1 0.0 2.2e-29 101.1 0.0 1.5 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.4 001126299.2_45728001_3 - 3e-14 52.4 0.1 7.8e-14 51.1 0.1 1.8 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO RNB PF00773.17 001177784.1_32928001_1 - 5.3e-90 301.9 0.1 9.5e-90 301.1 0.1 1.4 1 0 0 1 1 1 1 RNB domain Rrp44_S1 PF17215.1 001177784.1_32928001_1 - 1.1e-07 31.5 0.0 3.2e-07 30.1 0.0 1.8 1 0 0 1 1 1 1 S1 domain Rrp44_CSD1 PF17216.1 001177784.1_32928001_1 - 7.2e-07 28.9 0.0 1.5e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Rrp44-like cold shock domain PDDEXK_10 PF07788.9 178549.3_26229001_1 - 0.27 11.1 3.6 49 3.8 0.0 5.7 6 2 2 8 8 8 0 PD-(D/E)XK nuclease superfamily zf-H2C2_2 PF13465.4 178549.3_26229001_3 - 3.7e-115 371.5 129.7 2.5e-09 37.0 1.2 16.9 16 0 0 16 16 16 14 Zinc-finger double domain zf-C2H2 PF00096.24 178549.3_26229001_3 - 2.9e-57 187.9 147.1 1.1e-05 25.5 3.3 17.5 17 0 0 17 17 17 14 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 178549.3_26229001_3 - 1.1e-29 101.7 104.1 0.0015 18.3 1.1 15.9 15 0 0 15 15 15 13 C2H2-type zinc finger KRAB PF01352.25 178549.3_26229001_3 - 5.7e-22 77.0 0.2 1.2e-21 75.9 0.2 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 178549.3_26229001_3 - 2.8e-16 58.7 167.1 0.025 15.2 2.6 18.1 18 0 0 18 18 18 14 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 178549.3_26229001_3 - 7.9e-10 38.6 100.9 0.087 12.8 1.5 12.9 5 3 9 15 15 15 13 Zinc ribbon domain zf-C2H2_11 PF16622.3 178549.3_26229001_3 - 2.1e-06 27.3 65.5 0.036 13.7 0.1 13.8 14 0 0 14 14 14 7 zinc-finger C2H2-type MRP-S23 PF10484.7 178549.3_26229001_3 - 0.068 13.3 0.0 17 5.6 0.0 4.5 4 2 3 7 7 7 0 Mitochondrial ribosomal protein S23 DUF4548 PF15081.4 139240.3_26222001_1 - 1e-99 331.1 3.1 1.3e-99 330.8 3.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4548) NDUF_B6 PF09782.7 001246208.1_39721001_1 - 2.1e-51 174.0 1.8 2.4e-51 173.8 1.8 1.0 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit Sensor PF13796.4 001246208.1_39721001_1 - 0.17 11.8 0.1 0.21 11.5 0.1 1.1 1 0 0 1 1 1 0 Putative sensor PspB PF06667.10 001246208.1_39721001_1 - 1.4 8.9 4.2 0.67 9.9 1.3 1.9 2 0 0 2 2 2 0 Phage shock protein B Ion_trans PF00520.29 001172923.1_09929001_1 - 1.6e-257 849.4 82.2 5.6e-71 238.5 18.2 4.1 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.3 001172923.1_09929001_1 - 2.5e-35 119.9 0.0 6.3e-35 118.7 0.0 1.7 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated CAC1F_C PF16885.3 001172923.1_09929001_1 - 5.2e-35 121.7 11.3 1.2e-25 90.8 0.0 3.2 3 0 0 3 3 3 2 Voltage-gated calcium channel subunit alpha, C-term Ca_chan_IQ PF08763.9 001172923.1_09929001_1 - 2e-30 104.7 0.1 5.1e-30 103.4 0.1 1.7 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 001172923.1_09929001_1 - 5.4e-10 38.4 84.1 3.6e-08 32.4 9.6 8.6 7 3 1 8 8 8 5 Polycystin cation channel DUF4834 PF16118.3 001172923.1_09929001_1 - 0.66 10.8 0.0 0.66 10.8 0.0 7.3 9 0 0 9 9 9 0 Domain of unknown function (DUF4834) Rer1 PF03248.11 001172923.1_09929001_1 - 0.81 9.3 12.2 2.4 7.7 3.1 4.7 4 0 0 4 4 4 0 Rer1 family Med12-LCEWAV PF12145.6 001193292.1_45729001_1 - 5.7e-183 608.9 0.0 5.7e-183 608.9 0.0 2.4 2 0 0 2 2 2 1 Eukaryotic Mediator 12 subunit domain Med12-PQL PF12144.6 001193292.1_45729001_1 - 4.7e-80 268.2 35.7 4.7e-80 268.2 35.7 3.9 3 1 1 4 4 4 1 Eukaryotic Mediator 12 catenin-binding domain Med12 PF09497.8 001193292.1_45729001_1 - 2.4e-14 53.2 0.1 5.6e-14 52.0 0.1 1.6 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 PA26 PF04636.11 001193292.1_45729001_1 - 4.5 6.0 23.1 8 5.1 23.1 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) PIH1 PF08190.10 001169154.1_26224001_2 - 0.002 17.9 0.0 0.0026 17.5 0.0 1.2 1 0 0 1 1 1 1 pre-RNA processing PIH1/Nop17 DUF2053 PF09767.7 001242597.1_26222001_2 - 1.9e-51 174.3 2.7 1.9e-51 174.3 2.7 1.7 2 0 0 2 2 2 1 Predicted membrane protein (DUF2053) DUF2053 PF09767.7 001242597.1_26222001_3 - 1.1e-06 28.8 2.8 1.5e-06 28.3 2.8 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2053) Calreticulin PF00262.16 001174133.1_49824001_1 - 2.4e-79 266.7 14.8 1.6e-60 204.8 3.5 2.8 2 1 1 3 3 3 2 Calreticulin family Zip PF02535.20 001174133.1_49824001_1 - 0.079 12.0 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DDHD PF02862.15 001174133.1_49824001_1 - 0.082 12.9 1.3 0.12 12.3 1.3 1.2 1 0 0 1 1 1 0 DDHD domain CDC45 PF02724.12 001174133.1_49824001_1 - 0.94 7.6 18.8 1.6 6.8 18.8 1.3 1 0 0 1 1 1 0 CDC45-like protein Nucleo_P87 PF07267.9 001174133.1_49824001_1 - 8.9 4.9 14.4 14 4.3 14.4 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 zf-C2H2 PF00096.24 007156.4_26229001_1 - 2.2e-26 90.7 72.8 6.5e-05 23.0 0.6 11.1 11 0 0 11 11 11 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 007156.4_26229001_1 - 1.8e-19 68.6 72.5 0.0018 18.8 0.4 11.4 11 0 0 11 11 11 9 C2H2-type zinc finger zf-H2C2_2 PF13465.4 007156.4_26229001_1 - 5e-16 58.2 62.6 0.00021 21.5 0.4 10.8 11 1 1 12 12 12 7 Zinc-finger double domain zf-C2H2_8 PF15909.3 007156.4_26229001_1 - 2e-09 37.5 27.5 0.0012 19.0 5.2 6.2 1 1 4 6 6 6 5 C2H2-type zinc ribbon zf-C2H2_6 PF13912.4 007156.4_26229001_1 - 1.4e-08 34.3 26.1 0.00055 19.7 0.3 6.4 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_aberr PF17017.3 007156.4_26229001_1 - 2.5e-05 24.4 25.3 0.58 10.2 0.4 6.8 2 2 3 6 6 6 4 Aberrant zinc-finger Ig_3 PF13927.4 001177887.1_32924001_1 - 1.4e-11 44.7 1.1 1.6e-05 25.3 0.2 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001177887.1_32924001_1 - 3e-09 36.7 0.0 1.5e-05 24.8 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 001177887.1_32924001_1 - 5.7e-08 32.9 0.7 0.0049 17.1 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001177887.1_32924001_1 - 1.8e-07 31.1 1.1 0.00024 21.0 0.3 2.7 2 1 0 2 2 2 2 Immunoglobulin domain Shisa PF13908.4 001177887.1_32924001_1 - 2.6e-05 24.4 0.1 2.6e-05 24.4 0.1 1.7 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator WBP-1 PF11669.6 001177887.1_32924001_1 - 0.00063 20.2 0.0 0.0017 18.8 0.0 1.7 1 0 0 1 1 1 1 WW domain-binding protein 1 MAP17 PF15807.3 001177887.1_32924001_1 - 0.0011 19.1 0.0 0.0028 17.8 0.0 1.6 2 0 0 2 2 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 LYRIC PF15686.3 001177887.1_32924001_1 - 0.0095 15.4 0.0 0.0095 15.4 0.0 1.4 2 0 0 2 2 1 1 Lysine-rich CEACAM1 co-isolated protein family Orthoreo_P10 PF07204.9 001177887.1_32924001_1 - 0.01 15.6 0.3 0.025 14.4 0.3 1.6 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 EphA2_TM PF14575.4 001177887.1_32924001_1 - 0.011 16.4 0.0 0.03 15.0 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain V-set PF07686.15 001177887.1_32924001_1 - 0.018 15.1 0.1 0.14 12.2 0.1 2.5 2 0 0 2 2 2 0 Immunoglobulin V-set domain TMEM154 PF15102.4 001177887.1_32924001_1 - 0.025 14.4 1.8 0.048 13.4 0.6 2.0 1 1 1 2 2 2 0 TMEM154 protein family TMEM52 PF14979.4 001177887.1_32924001_1 - 0.033 14.0 0.0 0.12 12.2 0.0 2.0 2 0 0 2 2 1 0 Transmembrane 52 TMIE PF16038.3 001177887.1_32924001_1 - 0.035 13.8 0.3 0.087 12.6 0.3 1.6 1 0 0 1 1 1 0 TMIE protein Rax2 PF12768.5 001177887.1_32924001_1 - 0.037 13.5 0.0 0.068 12.6 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity tRNA_anti-like PF12869.5 001177887.1_32924001_1 - 0.039 13.6 0.0 0.084 12.5 0.0 1.5 1 0 0 1 1 1 0 tRNA_anti-like IncA PF04156.12 001177887.1_32924001_1 - 0.059 13.0 0.0 0.093 12.4 0.0 1.3 1 0 0 1 1 1 0 IncA protein Sigma_reg_N PF13800.4 001177887.1_32924001_1 - 0.084 13.0 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 Sigma factor regulator N-terminal ETRAMP PF09716.8 001177887.1_32924001_1 - 0.095 12.6 0.1 0.095 12.6 0.1 2.4 2 1 0 2 2 1 0 Malarial early transcribed membrane protein (ETRAMP) FAM176 PF14851.4 001177887.1_32924001_1 - 0.14 11.7 0.4 0.3 10.6 0.0 1.7 2 0 0 2 2 2 0 FAM176 family DUF4834 PF16118.3 001177887.1_32924001_1 - 0.14 13.0 0.0 0.33 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) SIT PF15330.4 001177887.1_32924001_1 - 0.15 12.4 0.6 0.9 9.8 0.4 2.1 1 1 1 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT DUF843 PF05814.9 001177887.1_32924001_1 - 0.35 10.8 3.3 0.36 10.7 0.0 2.4 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF843) Globin PF00042.20 001171503.1_37921001_1 - 2.2e-31 108.5 0.2 5.1e-31 107.3 0.0 1.6 2 0 0 2 2 2 1 Globin UQ_con PF00179.24 182697.2_26229001_1 - 1.6e-15 56.8 0.2 3.1e-09 36.5 0.1 2.2 1 1 1 2 2 2 2 Ubiquitin-conjugating enzyme MHC_I PF00129.16 001008843.2_45724001_1 - 9.7e-88 292.3 0.8 1.3e-87 291.9 0.8 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001008843.2_45724001_1 - 9.2e-15 54.8 0.0 2e-14 53.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001008843.2_45724001_1 - 7.9e-09 35.2 1.2 7.9e-09 35.2 1.2 1.9 2 0 0 2 2 2 1 MHC_I C-terminus Ig_3 PF13927.4 001008843.2_45724001_1 - 5e-05 23.7 0.5 0.11 13.0 0.0 2.7 2 1 1 3 3 3 2 Immunoglobulin domain ig PF00047.23 001008843.2_45724001_1 - 0.00023 21.1 0.0 0.00044 20.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 001008843.2_45724001_1 - 0.041 13.8 0.0 0.094 12.7 0.0 1.6 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.4 001008843.2_45724001_1 - 0.13 12.5 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain Ion_trans_2 PF07885.14 001172976.1_09923001_1 - 1.4e-32 111.4 18.6 3.9e-17 61.9 3.7 3.0 3 0 0 3 3 3 2 Ion channel Adeno_E3_CR2 PF02439.13 001172976.1_09923001_1 - 0.042 13.5 0.4 0.12 12.0 0.4 1.8 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Kelch_6 PF13964.4 001163729.2_32924001_1 - 1.2e-42 142.7 7.1 1.2e-07 31.6 0.0 6.4 4 1 2 6 6 6 6 Kelch motif Kelch_2 PF07646.13 001163729.2_32924001_1 - 4.5e-41 137.2 13.9 1.6e-10 40.4 0.1 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.23 001163729.2_32924001_1 - 9.6e-39 130.6 8.0 2.8e-06 26.7 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.4 001163729.2_32924001_1 - 3.6e-30 103.6 12.9 6.8e-08 32.2 0.3 7.1 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.4 001163729.2_32924001_1 - 7.7e-30 102.4 12.4 3.3e-06 27.1 0.5 7.5 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.4 001163729.2_32924001_1 - 8.9e-30 102.0 14.1 3.6e-06 26.7 0.1 6.7 7 0 0 7 7 7 6 Kelch motif VWA PF00092.26 001173043.1_09924001_3 - 8.1e-79 263.8 0.1 3.1e-40 138.2 0.1 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.4 001173043.1_09924001_3 - 1.2e-25 90.2 0.0 7.1e-12 45.8 0.0 2.8 3 0 0 3 3 3 2 von Willebrand factor type A domain LCCL PF03815.17 001173043.1_09924001_3 - 7.3e-21 74.0 0.0 1.7e-20 72.8 0.0 1.6 1 0 0 1 1 1 1 LCCL domain VWA_3 PF13768.4 001173043.1_09924001_3 - 0.00039 20.2 0.0 0.61 9.8 0.0 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain CEP76-C2 PF15627.4 001100514.1_45726001_3 - 1.2e-60 203.5 0.0 2.3e-60 202.6 0.0 1.5 1 0 0 1 1 1 1 CEP76 C2 domain Transglut_core3 PF13471.4 001100514.1_45726001_3 - 0.0039 16.9 0.3 0.0083 15.9 0.3 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily Transglut_core PF01841.17 001100514.1_45726001_3 - 0.0043 17.3 0.1 0.0087 16.4 0.1 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF2367 PF10164.7 001172827.1_09922001_1 - 1.5e-33 115.3 4.6 2.3e-33 114.7 4.6 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2367) TRAF_BIRC3_bd PF16673.3 005658.4_26229001_3 - 1.7e-15 56.4 3.2 2.8e-15 55.7 3.2 1.3 1 0 0 1 1 1 1 TNF receptor-associated factor BIRC3 binding domain ERG2_Sigma1R PF04622.10 001172992.1_09924001_3 - 2.3e-62 209.9 0.2 3.4e-62 209.4 0.2 1.1 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein DUF4337 PF14235.4 001172992.1_09924001_3 - 0.13 12.2 0.5 0.22 11.5 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) G6B PF15096.4 138275.2_26225001_2 - 1.2e-96 322.6 6.5 8.5e-73 244.7 2.3 2.2 1 1 1 2 2 2 2 G6B family FbpA PF05833.9 001170586.1_45729001_3 - 9.4e-39 133.3 13.4 2.2e-38 132.1 13.4 1.6 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) DUF3441 PF11923.6 001170586.1_45729001_3 - 3.8e-29 100.8 0.0 3.8e-29 100.8 0.0 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF3441) DUF814 PF05670.11 001170586.1_45729001_3 - 1.2e-23 82.8 0.0 3.9e-23 81.2 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF814) LBP_BPI_CETP_C PF02886.15 001195804.1_37924001_1 - 1e-82 277.1 0.3 1.9e-82 276.2 0.3 1.5 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.23 001195804.1_37924001_1 - 1.6e-50 170.8 0.0 3.5e-50 169.7 0.0 1.6 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain PHA_gran_rgn PF09650.8 001195804.1_37924001_1 - 0.13 12.4 0.0 0.58 10.4 0.0 2.1 1 1 0 1 1 1 0 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) DUF2315 PF10231.7 001037769.2_45722001_2 - 6.6e-52 174.8 5.4 9.4e-52 174.3 5.4 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2315) Homeobox PF00046.27 001135624.2_39722001_1 - 7.5e-23 80.0 7.4 1.2e-22 79.4 7.4 1.3 1 0 0 1 1 1 1 Homeobox domain Kunitz_BPTI PF00014.21 001177321.1_45727001_2 - 3.8e-35 119.8 29.4 5e-18 65.0 7.9 2.5 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain WD40 PF00400.30 001168653.1_45727001_2 - 8.2e-31 105.5 27.7 3.2e-08 34.0 0.1 11.8 12 0 0 12 12 12 4 WD domain, G-beta repeat Utp12 PF04003.10 001168653.1_45727001_2 - 1.7e-22 79.6 0.4 2.6e-22 79.0 0.4 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.5 001168653.1_45727001_2 - 3.9e-18 65.4 0.0 0.52 10.5 0.0 9.3 5 3 4 10 10 10 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 001168653.1_45727001_2 - 3.2e-07 30.3 0.5 0.006 16.4 0.0 4.7 2 1 2 5 5 5 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.3 001168653.1_45727001_2 - 2.1e-05 23.5 0.3 0.55 9.0 0.1 4.1 2 2 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.10 001168653.1_45727001_2 - 3.7e-05 23.4 0.0 1 9.2 0.0 4.1 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat WD40_like PF17005.3 001168653.1_45727001_2 - 0.00065 19.0 0.1 0.0085 15.3 0.0 2.5 3 0 0 3 3 3 1 WD40-like domain DUF1513 PF07433.9 001168653.1_45727001_2 - 0.012 14.6 0.0 0.82 8.5 0.0 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1513) TFIIIC_delta PF12657.5 001168653.1_45727001_2 - 0.15 11.8 0.0 1.1e+02 2.6 0.0 4.2 5 0 0 5 5 5 0 Transcription factor IIIC subunit delta N-term PQQ_3 PF13570.4 001168653.1_45727001_2 - 0.98 9.9 5.6 1.2 9.5 1.3 3.2 1 1 1 2 2 2 0 PQQ-like domain Pyr_redox_2 PF07992.12 001185045.1_08024001_2 - 1.6e-62 211.3 0.2 2.4e-62 210.7 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.20 001185045.1_08024001_2 - 1e-35 122.2 2.1 1.4e-35 121.7 0.7 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.25 001185045.1_08024001_2 - 3.5e-22 78.6 6.1 4.6e-20 71.8 0.4 3.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 001185045.1_08024001_2 - 8.5e-19 67.8 0.1 1.7e-18 66.8 0.1 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.5 001185045.1_08024001_2 - 2.8e-07 30.1 0.1 1e-06 28.3 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.22 001185045.1_08024001_2 - 2.9e-06 26.5 5.0 0.0021 17.1 2.5 2.8 3 0 0 3 3 3 2 FAD binding domain AlaDh_PNT_C PF01262.19 001185045.1_08024001_2 - 0.0016 17.7 3.0 0.2 10.8 0.8 2.4 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.20 001185045.1_08024001_2 - 0.0022 17.0 5.1 0.01 14.8 1.3 3.0 3 0 0 3 3 3 1 Glucose inhibited division protein A HI0933_like PF03486.12 001185045.1_08024001_2 - 0.0027 16.3 2.5 0.083 11.4 0.5 2.7 3 0 0 3 3 3 1 HI0933-like protein NAD_binding_8 PF13450.4 001185045.1_08024001_2 - 0.0058 16.7 0.4 0.0058 16.7 0.4 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.4 001185045.1_08024001_2 - 0.024 13.7 0.0 0.036 13.1 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.15 001185045.1_08024001_2 - 0.066 12.3 0.1 0.15 11.1 0.1 1.6 1 0 0 1 1 1 0 Thi4 family FAD_binding_3 PF01494.17 001185045.1_08024001_2 - 0.14 11.3 2.4 0.97 8.5 0.4 2.2 2 0 0 2 2 2 0 FAD binding domain 2-Hacid_dh_C PF02826.17 001185045.1_08024001_2 - 0.16 11.1 0.2 2.8 7.1 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DAO PF01266.22 001185045.1_08024001_2 - 0.2 11.1 8.4 0.06 12.8 2.8 2.6 3 1 0 3 3 3 0 FAD dependent oxidoreductase ELM2 PF01448.22 001168000.1_45729001_3 - 5.6e-09 36.5 0.1 1.1e-08 35.6 0.1 1.5 1 0 0 1 1 1 1 ELM2 domain Myb_DNA-binding PF00249.29 001168000.1_45729001_3 - 1.1e-05 25.3 0.1 2.1e-05 24.4 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.3 001168000.1_45729001_3 - 0.021 14.6 0.1 0.041 13.6 0.1 1.4 1 0 0 1 1 1 0 Myb DNA-binding like DUF3538 PF12057.6 001242746.1_37627001_1 - 2.6e-43 146.3 0.1 6.1e-43 145.1 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3538) ubiquitin PF00240.21 001242746.1_37627001_1 - 6.3e-19 67.3 0.1 1e-18 66.7 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 001242746.1_37627001_1 - 6.3e-07 29.0 0.1 1.1e-06 28.2 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 001242746.1_37627001_1 - 0.0012 19.2 0.0 0.13 12.7 0.0 2.5 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.4 001242746.1_37627001_1 - 0.0043 17.0 0.0 0.012 15.6 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 001242746.1_37627001_1 - 0.051 13.9 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain PilJ PF13675.4 001242746.1_37627001_1 - 0.061 13.3 0.1 0.22 11.5 0.1 2.0 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term RAG1 PF12940.5 001171140.1_37927001_1 - 0 1268.5 0.6 0 1268.0 0.6 1.2 1 0 0 1 1 1 1 Recombination-activation protein 1 (RAG1), recombinase RAG1_imp_bd PF12560.6 001171140.1_37927001_1 - 1.9e-121 404.9 14.8 3.8e-121 403.9 14.8 1.5 1 0 0 1 1 1 1 RAG1 importin binding zf-RAG1 PF10426.7 001171140.1_37927001_1 - 3.7e-14 52.4 10.6 7.6e-13 48.2 3.8 2.6 2 0 0 2 2 2 2 Recombination-activating protein 1 zinc-finger domain zf-C3HC4_2 PF13923.4 001171140.1_37927001_1 - 1.2e-06 28.1 13.0 1.2e-06 28.1 13.0 3.6 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001171140.1_37927001_1 - 5.9e-06 25.9 13.9 5.9e-06 25.9 13.9 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 001171140.1_37927001_1 - 0.00035 20.3 8.3 0.00035 20.3 8.3 2.6 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.4 001171140.1_37927001_1 - 0.0096 15.9 13.6 0.0096 15.9 13.6 3.1 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.3 001171140.1_37927001_1 - 0.011 15.8 10.8 0.011 15.8 10.8 3.4 4 0 0 4 4 4 0 zinc RING finger of MSL2 zf-RING_2 PF13639.4 001171140.1_37927001_1 - 0.011 15.8 13.6 0.011 15.8 13.6 3.8 3 0 0 3 3 3 0 Ring finger domain zf-RING_UBOX PF13445.4 001171140.1_37927001_1 - 0.4 10.6 18.4 0.049 13.5 12.9 2.5 2 0 0 2 2 2 0 RING-type zinc-finger Galactosyl_T PF01762.19 133553.2_45724001_2 - 2.2e-66 223.3 0.0 2.7e-66 223.0 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.14 133553.2_45724001_2 - 0.041 13.2 0.0 0.055 12.8 0.0 1.2 1 0 0 1 1 1 0 Fringe-like INPP5B_PH PF16776.3 001100755.1_45728001_2 - 1.1e-56 190.6 0.0 1.9e-56 189.7 0.0 1.4 1 0 0 1 1 1 1 Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain RhoGAP PF00620.25 001100755.1_45728001_2 - 2.6e-26 92.1 0.1 4.9e-26 91.2 0.1 1.4 1 0 0 1 1 1 1 RhoGAP domain Exo_endo_phos PF03372.21 001100755.1_45728001_2 - 7.3e-10 39.0 0.1 3.7e-09 36.7 0.0 2.3 3 0 0 3 3 3 1 Endonuclease/Exonuclease/phosphatase family CMS1 PF14617.4 032359.3_26223001_3 - 4.7e-31 107.9 1.9 9.7e-31 106.9 1.9 1.4 1 1 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.27 032359.3_26223001_3 - 4.5e-06 26.4 0.0 9e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Glyco_transf_64 PF09258.8 001130540.1_45727001_1 - 6.4e-105 349.8 0.6 9e-105 349.3 0.6 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Exostosin PF03016.13 001130540.1_45727001_1 - 2.4e-62 210.7 0.0 4.1e-62 210.0 0.0 1.4 1 0 0 1 1 1 1 Exostosin family A2M_comp PF07678.12 001172903.1_09929001_1 - 3.8e-56 190.2 1.3 2.1e-55 187.7 1.3 2.0 1 1 0 1 1 1 1 A-macroglobulin complement component A2M_recep PF07677.12 001172903.1_09929001_1 - 8.5e-31 106.5 0.4 3.7e-30 104.4 0.2 2.4 2 0 0 2 2 2 1 A-macroglobulin receptor A2M PF00207.20 001172903.1_09929001_1 - 9.8e-31 105.3 0.8 2.1e-29 101.1 0.1 3.6 4 0 0 4 4 4 1 Alpha-2-macroglobulin family NTR PF01759.19 001172903.1_09929001_1 - 3.5e-29 100.6 0.1 8.7e-29 99.3 0.1 1.7 1 0 0 1 1 1 1 UNC-6/NTR/C345C module A2M_N_2 PF07703.12 001172903.1_09929001_1 - 1.3e-28 100.0 0.0 5.8e-25 88.1 0.0 4.2 4 1 0 4 4 4 1 Alpha-2-macroglobulin family N-terminal region A2M_N PF01835.17 001172903.1_09929001_1 - 7.6e-19 67.8 0.1 4.7e-16 58.9 0.0 3.4 3 0 0 3 3 3 1 MG2 domain Thiol-ester_cl PF10569.7 001172903.1_09929001_1 - 2.7e-13 49.2 0.1 6e-13 48.1 0.1 1.6 1 0 0 1 1 1 1 Alpha-macro-globulin thiol-ester bond-forming region ANATO PF01821.16 001172903.1_09929001_1 - 1e-12 48.5 8.7 2.8e-12 47.2 8.7 1.8 1 0 0 1 1 1 1 Anaphylotoxin-like domain Rib PF08428.8 001172903.1_09929001_1 - 0.0092 15.8 0.3 0.7 9.8 0.0 2.9 2 0 0 2 2 2 1 Rib/alpha-like repeat MAP7 PF05672.9 001168466.1_26228001_1 - 3.1e-46 156.9 83.2 3.1e-46 156.9 83.2 4.1 2 2 1 3 3 3 1 MAP7 (E-MAP-115) family YbgT_YccB PF08173.9 001168466.1_26228001_1 - 4.1 7.5 5.6 8 6.6 5.6 1.5 1 0 0 1 1 1 0 Membrane bound YbgT-like protein Proton_antipo_N PF00662.18 001168466.1_26228001_2 - 1.9 8.5 3.9 0.53 10.3 0.1 2.0 2 0 0 2 2 2 0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus C1-set PF07654.13 001173435.1_45723001_3 - 5.4e-12 45.9 0.0 8.8e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001173435.1_45723001_3 - 0.0013 19.2 0.1 0.91 10.0 0.0 2.2 1 1 1 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001173435.1_45723001_3 - 0.009 16.2 0.0 0.015 15.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 001173435.1_45723001_3 - 0.14 12.1 0.0 0.52 10.3 0.0 1.8 1 1 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Ferric_reduct PF01794.17 001164460.1_26223001_3 - 3.6e-13 49.6 5.3 6.7e-13 48.8 5.3 1.5 1 0 0 1 1 1 1 Ferric reductase like transmembrane component Neugrin PF06413.9 001033900.2_45723001_1 - 2.6e-88 295.7 0.6 3.3e-88 295.4 0.6 1.1 1 0 0 1 1 1 1 Neugrin MRP-L20 PF12824.5 001033900.2_45723001_1 - 0.0021 18.1 0.4 0.0021 18.1 0.4 2.2 2 1 0 2 2 2 1 Mitochondrial ribosomal protein subunit L20 ABC_transp_aux PF09822.7 001177685.1_45725001_3 - 1.9e-09 37.2 0.1 2.9e-09 36.6 0.1 1.2 1 0 0 1 1 1 1 ABC-type uncharacterized transport system DDOST_48kD PF03345.12 001177685.1_45725001_3 - 0.044 12.5 0.0 6 5.5 0.0 2.1 2 0 0 2 2 2 0 Oligosaccharyltransferase 48 kDa subunit beta C1-set PF07654.13 001173535.1_40422001_3 - 2.2e-22 79.2 0.0 3.1e-22 78.7 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Cadherin PF00028.15 001013011.2_39726001_1 - 2.8e-81 267.9 0.0 2.2e-18 66.3 0.0 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001013011.2_39726001_1 - 5.9e-39 131.6 0.5 1.6e-35 120.7 0.1 3.9 5 0 0 5 5 5 2 Cadherin-like Cadherin_C_2 PF16492.3 001013011.2_39726001_1 - 8.9e-29 100.0 0.3 2.1e-28 98.8 0.3 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001013011.2_39726001_1 - 4.9e-05 23.2 0.8 0.013 15.3 0.1 3.7 4 0 0 4 4 4 1 Cadherin-like Carn_acyltransf PF00755.18 001170593.1_45728001_2 - 2.6e-195 650.3 0.0 3.1e-195 650.1 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase MCM PF00493.21 033651.1_45727001_2 - 2.9e-134 447.2 0.1 4e-134 446.7 0.1 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_OB PF17207.1 033651.1_45727001_2 - 1.3e-39 134.8 0.9 2.2e-39 134.0 0.9 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_N PF14551.4 033651.1_45727001_2 - 7.7e-17 61.7 1.0 3.2e-16 59.6 0.1 2.4 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.19 033651.1_45727001_2 - 6.3e-08 32.1 0.1 1.8e-05 24.1 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.12 033651.1_45727001_2 - 8.2e-08 32.2 0.0 4.6e-07 29.8 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.9 033651.1_45727001_2 - 2.3e-05 24.1 0.0 4.5e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.27 033651.1_45727001_2 - 0.016 15.5 0.0 0.061 13.6 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.24 033651.1_45727001_2 - 0.036 13.6 0.0 4.6 6.8 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain NTPase_1 PF03266.13 033651.1_45727001_2 - 0.12 12.1 0.0 6.2 6.6 0.0 2.6 1 1 1 2 2 2 0 NTPase Elf1 PF05129.11 033651.1_45727001_2 - 0.26 11.2 2.2 0.86 9.6 2.2 1.8 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like MHC_I PF00129.16 001008886.2_45726001_1 - 1.1e-86 288.8 0.8 1.5e-86 288.4 0.8 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001008886.2_45726001_1 - 9.8e-15 54.7 0.0 1.8e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001008886.2_45726001_1 - 0.00072 20.0 0.1 0.04 14.4 0.0 2.4 1 1 1 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001008886.2_45726001_1 - 0.046 13.7 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain DUF1049 PF06305.9 001008886.2_45726001_1 - 0.048 13.3 0.0 0.095 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Pkinase PF00069.23 053343.3_45729001_3 - 5.9e-74 248.6 0.0 7.6e-74 248.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 053343.3_45729001_3 - 4e-33 114.7 0.0 5.2e-33 114.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 053343.3_45729001_3 - 0.00069 18.9 0.0 0.0011 18.3 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 053343.3_45729001_3 - 0.014 14.6 0.0 0.022 14.0 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Ank_2 PF12796.5 001106084.2_45729001_2 - 4.6e-108 353.9 46.1 2.2e-15 56.9 0.2 11.2 4 4 7 12 12 12 12 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001106084.2_45729001_2 - 1.2e-107 349.9 43.8 1.4e-12 47.5 0.4 14.8 5 5 10 15 15 15 14 Ankyrin repeats (many copies) Ank PF00023.28 001106084.2_45729001_2 - 1.8e-107 347.4 50.3 1.6e-07 31.3 0.1 18.5 18 0 0 18 18 18 16 Ankyrin repeat Ank_4 PF13637.4 001106084.2_45729001_2 - 4.6e-101 329.9 27.4 1.7e-12 47.4 0.1 14.5 7 4 8 16 16 16 15 Ankyrin repeats (many copies) Ank_3 PF13606.4 001106084.2_45729001_2 - 1.2e-92 292.5 31.9 2.9e-06 27.0 0.0 18.8 20 0 0 20 20 20 16 Ankyrin repeat PARP PF00644.18 001106084.2_45729001_2 - 3.3e-27 95.4 3.8 5.2e-25 88.2 3.8 2.3 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain SAM_2 PF07647.15 001106084.2_45729001_2 - 1.7e-14 53.5 0.4 3.6e-14 52.5 0.4 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 001106084.2_45729001_2 - 3.1e-12 46.6 0.6 6.8e-12 45.5 0.6 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Vps39_1 PF10366.7 001106084.2_45729001_2 - 0.094 12.9 1.0 20 5.4 0.0 3.4 4 0 0 4 4 4 0 Vacuolar sorting protein 39 domain 1 GLTP PF08718.9 001109235.2_45729001_3 - 5e-42 143.5 0.0 8.6e-42 142.8 0.0 1.3 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) PH PF00169.27 001109235.2_45729001_3 - 6.2e-11 42.6 0.0 1.2e-10 41.7 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 001109235.2_45729001_3 - 0.00059 19.9 0.0 0.0011 19.0 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.4 001109235.2_45729001_3 - 0.0016 18.7 0.1 0.0049 17.2 0.1 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain IL8 PF00048.18 001034220.2_06522001_3 - 5.4e-21 74.4 0.5 1.1e-20 73.3 0.5 1.6 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like DNA_pol_E_B PF04042.14 001169108.1_45724001_2 - 3e-52 176.9 1.0 4.7e-52 176.3 1.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Dpoe2NT PF12213.6 001169108.1_45724001_2 - 5.3e-32 109.8 0.9 1.4e-31 108.5 0.9 1.7 1 0 0 1 1 1 1 DNA polymerases epsilon N terminal Tsc35 PF15079.4 001169108.1_45724001_2 - 0.18 11.2 0.0 0.35 10.3 0.0 1.3 1 0 0 1 1 1 0 Testis-specific protein 35 Galactosyl_T PF01762.19 053932.1_45729001_3 - 4.9e-47 160.2 0.0 8.1e-47 159.4 0.0 1.4 1 0 0 1 1 1 1 Galactosyltransferase DUF543 PF04418.10 001173556.1_45722001_2 - 2.3e-22 78.6 0.1 3.2e-22 78.2 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF543) Pkinase PF00069.23 000294.2_26229001_1 - 9.2e-78 261.1 0.0 1.2e-77 260.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 000294.2_26229001_1 - 1.7e-30 106.0 0.0 2.5e-30 105.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 000294.2_26229001_1 - 1e-05 24.9 0.0 0.00092 18.5 0.0 2.1 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.12 000294.2_26229001_1 - 0.0025 17.1 0.0 0.0041 16.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 000294.2_26229001_1 - 0.07 12.6 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 RIO1 family APH PF01636.21 000294.2_26229001_1 - 0.12 12.2 5.7 0.2 11.4 0.2 2.9 2 1 1 3 3 3 0 Phosphotransferase enzyme family FAD-oxidase_C PF02913.17 053350.2_45725001_3 - 1.6e-59 201.4 0.0 3.6e-59 200.3 0.0 1.5 2 0 0 2 2 2 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.21 053350.2_45725001_3 - 1.1e-39 135.3 0.0 1.9e-39 134.5 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain MRVI1 PF05781.10 001100163.2_26229001_1 - 6.1e-212 704.9 5.6 8.2e-212 704.5 5.6 1.1 1 0 0 1 1 1 1 MRVI1 protein Guanylin PF02058.13 001172902.1_09922001_1 - 8.4e-34 115.8 0.9 1.2e-33 115.3 0.9 1.2 1 0 0 1 1 1 1 Guanylin precursor Plexin_cytopl PF08337.10 001105988.2_45729001_1 - 7.3e-259 859.9 0.6 9e-259 859.6 0.6 1.1 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Sema PF01403.17 001105988.2_45729001_1 - 7.5e-73 245.6 0.0 1.1e-72 245.1 0.0 1.2 1 0 0 1 1 1 1 Sema domain TIG PF01833.22 001105988.2_45729001_1 - 5.5e-41 138.4 21.9 3.4e-13 49.4 0.7 5.4 6 0 0 6 6 6 4 IPT/TIG domain PSI PF01437.23 001105988.2_45729001_1 - 3.5e-19 69.0 62.4 9.1e-10 38.8 16.1 3.8 3 0 0 3 3 3 3 Plexin repeat IncA PF04156.12 001105988.2_45729001_1 - 1.8 8.2 6.1 0.13 11.9 0.9 1.6 2 0 0 2 2 2 0 IncA protein Kelch_3 PF13415.4 001174153.1_26223001_2 - 5.2e-33 112.5 4.9 7.4e-10 38.7 0.1 5.4 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_4 PF13418.4 001174153.1_26223001_2 - 1.5e-32 111.1 2.3 3e-07 30.1 0.0 5.6 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.13 001174153.1_26223001_2 - 5.7e-29 98.8 1.0 2.6e-14 52.4 0.0 5.1 4 1 0 4 4 4 4 Kelch motif Kelch_1 PF01344.23 001174153.1_26223001_2 - 7.3e-26 89.4 0.1 2.3e-06 27.0 0.0 4.8 5 0 0 5 5 5 4 Kelch motif Kelch_6 PF13964.4 001174153.1_26223001_2 - 5.4e-24 83.5 0.9 7.3e-05 22.8 0.0 4.6 2 1 2 4 4 4 4 Kelch motif Kelch_5 PF13854.4 001174153.1_26223001_2 - 6.1e-23 80.2 8.0 3.9e-05 23.4 0.0 6.4 7 0 0 7 7 7 5 Kelch motif V_ATPase_I PF01496.17 001174153.1_26223001_2 - 0.2 9.4 5.7 0.28 8.9 5.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Connexin PF00029.17 001174153.1_26223001_2 - 4.4 6.9 7.4 8.2 6.0 7.4 1.4 1 0 0 1 1 1 0 Connexin Homeobox PF00046.27 053712.1_45725001_2 - 5.4e-21 74.0 3.7 8.6e-21 73.4 3.7 1.3 1 0 0 1 1 1 1 Homeobox domain DUF2457 PF10446.7 053712.1_45725001_2 - 0.62 9.0 4.3 0.86 8.6 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) zf-H2C2_2 PF13465.4 001170404.1_45727001_3 - 2.9e-69 226.5 132.8 1.2e-08 34.9 1.8 13.5 14 0 0 14 14 14 11 Zinc-finger double domain zf-C2H2 PF00096.24 001170404.1_45727001_3 - 3.4e-51 168.8 119.3 2.5e-05 24.4 4.1 12.6 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001170404.1_45727001_3 - 1.1e-25 87.9 111.7 0.0081 16.8 1.8 12.8 12 0 0 12 12 12 11 C2H2-type zinc finger KRAB PF01352.25 001170404.1_45727001_3 - 9e-24 82.8 1.4 2.1e-23 81.5 1.4 1.7 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 001170404.1_45727001_3 - 0.00092 19.0 96.7 0.07 13.0 1.6 12.1 12 0 0 12 12 12 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001170404.1_45727001_3 - 0.057 13.6 0.5 0.057 13.6 0.5 11.1 11 0 0 11 11 11 0 Zinc-finger double-stranded RNA-binding Pkinase_Tyr PF07714.15 001185038.1_08026001_1 - 2.8e-103 344.6 0.0 4e-103 344.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001185038.1_08026001_1 - 6.9e-44 150.1 0.0 1.2e-30 106.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.4 001185038.1_08026001_1 - 1.7e-26 92.5 5.1 1.8e-10 41.1 0.7 4.6 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.14 001185038.1_08026001_1 - 1.5e-18 66.5 8.0 1.6e-10 40.8 0.4 5.4 5 2 0 5 5 5 4 Immunoglobulin I-set domain ig PF00047.23 001185038.1_08026001_1 - 1.6e-18 66.5 7.7 9.4e-15 54.4 1.7 3.9 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.4 001185038.1_08026001_1 - 3.7e-15 55.9 8.3 2e-06 27.9 0.9 5.0 5 0 0 5 5 5 4 Immunoglobulin domain V-set PF07686.15 001185038.1_08026001_1 - 0.00054 20.0 9.8 0.0048 16.9 2.0 5.2 4 3 1 5 5 5 1 Immunoglobulin V-set domain Ig_4 PF16680.3 001185038.1_08026001_1 - 0.001 19.2 3.5 0.13 12.5 0.1 3.7 3 1 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.3 001185038.1_08026001_1 - 0.003 17.8 3.5 1 9.7 0.0 3.4 3 1 0 3 3 2 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain APH PF01636.21 001185038.1_08026001_1 - 0.074 12.8 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family C2-set_2 PF08205.10 001185038.1_08026001_1 - 0.28 11.1 4.3 1.7 8.6 0.0 3.3 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain SAA PF00277.16 001127380.2_26225001_2 - 1.6e-27 95.9 0.7 2.6e-27 95.2 0.7 1.3 1 0 0 1 1 1 1 Serum amyloid A protein DUF1725 PF08333.9 001127380.2_26225001_3 - 0.018 14.6 0.4 0.018 14.6 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1725) SVA PF05326.9 001173400.1_09921001_1 - 1.2e-51 173.7 0.1 1.4e-51 173.5 0.1 1.0 1 0 0 1 1 1 1 Seminal vesicle autoantigen (SVA) Peptidase_M14 PF00246.22 016998.3_45724001_3 - 8.3e-95 317.8 0.0 1.1e-94 317.4 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.14 016998.3_45724001_3 - 1.8e-20 72.9 0.1 4.8e-20 71.6 0.1 1.8 1 0 0 1 1 1 1 Carboxypeptidase activation peptide DEAD PF00270.27 001005895.2_45729001_3 - 4.9e-29 101.2 0.0 7.2e-29 100.7 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001005895.2_45729001_3 - 1e-25 90.1 0.0 1.9e-25 89.3 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Trypsin PF00089.24 001195801.1_37924001_1 - 2.6e-67 226.7 0.0 3.9e-67 226.2 0.0 1.3 1 0 0 1 1 1 1 Trypsin Gla PF00594.18 001195801.1_37924001_1 - 1.1e-17 63.8 1.7 1.1e-17 63.8 1.7 2.0 2 0 0 2 2 2 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FXa_inhibition PF14670.4 001195801.1_37924001_1 - 1.2e-10 41.3 9.0 1.2e-10 41.3 9.0 2.8 2 1 0 2 2 2 2 Coagulation Factor Xa inhibitory site Trypsin_2 PF13365.4 001195801.1_37924001_1 - 0.00014 22.7 0.0 0.00024 21.9 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001195801.1_37924001_1 - 0.0025 18.0 0.5 0.0088 16.3 0.1 2.1 2 1 0 2 2 2 1 Domain of unknown function (DUF1986) cEGF PF12662.5 001195801.1_37924001_1 - 0.0087 15.8 0.8 0.0087 15.8 0.8 2.6 2 0 0 2 2 2 1 Complement Clr-like EGF-like hEGF PF12661.5 001195801.1_37924001_1 - 0.11 13.1 19.2 0.5 11.0 8.1 3.1 2 0 0 2 2 2 0 Human growth factor-like EGF EGF_2 PF07974.11 001195801.1_37924001_1 - 7.8 6.8 31.5 0.57 10.5 19.1 2.8 2 0 0 2 2 2 0 EGF-like domain SPRY PF00622.26 001170461.1_45725001_1 - 2.8e-11 43.5 0.1 5.7e-11 42.5 0.1 1.5 1 0 0 1 1 1 1 SPRY domain zf-RING_UBOX PF13445.4 001170461.1_45725001_1 - 7.2e-11 41.8 6.3 8.4e-11 41.6 3.9 2.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 001170461.1_45725001_1 - 1.9e-10 40.6 8.6 1.9e-10 40.6 8.6 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.22 001170461.1_45725001_1 - 7.3e-09 35.5 1.2 7.3e-09 35.5 1.2 2.9 3 0 0 3 3 2 1 B-box zinc finger zf-C3HC4 PF00097.23 001170461.1_45725001_1 - 8.5e-09 35.0 6.5 2.2e-08 33.7 6.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001170461.1_45725001_1 - 7.9e-08 32.3 6.0 2.6e-07 30.7 6.0 2.0 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 001170461.1_45725001_1 - 9.3e-08 31.7 7.5 5.2e-07 29.3 7.7 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PRY PF13765.4 001170461.1_45725001_1 - 9.1e-07 28.3 0.1 2.1e-06 27.1 0.1 1.7 1 0 0 1 1 1 1 SPRY-associated domain zf-C3HC4_3 PF13920.4 001170461.1_45725001_1 - 2.5e-06 27.1 3.9 2.5e-06 27.1 3.9 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001170461.1_45725001_1 - 2.6e-06 27.1 4.8 2.6e-06 27.1 4.8 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_10 PF16685.3 001170461.1_45725001_1 - 0.0015 18.5 2.6 0.0042 17.1 2.6 1.8 1 0 0 1 1 1 1 zinc RING finger of MSL2 FAM76 PF16046.3 001170461.1_45725001_1 - 0.006 15.8 6.2 0.0093 15.2 6.2 1.2 1 0 0 1 1 1 1 FAM76 protein U-box PF04564.13 001170461.1_45725001_1 - 0.029 14.4 0.0 0.054 13.5 0.0 1.4 1 0 0 1 1 1 0 U-box domain zf-RING_6 PF14835.4 001170461.1_45725001_1 - 0.068 12.9 5.0 0.087 12.6 2.9 2.3 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-Nse PF11789.6 001170461.1_45725001_1 - 0.071 12.8 2.9 0.15 11.7 2.9 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Fib_alpha PF08702.8 001170461.1_45725001_1 - 0.27 11.3 6.9 0.43 10.6 6.9 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family zf-rbx1 PF12678.5 001170461.1_45725001_1 - 0.54 10.4 4.0 2 8.6 4.0 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain OmpH PF03938.12 001170461.1_45725001_1 - 0.58 10.0 13.5 0.92 9.4 13.5 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Phasin PF05597.9 001170461.1_45725001_1 - 0.75 9.7 7.9 1.2 9.0 7.9 1.3 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Prok-RING_4 PF14447.4 001170461.1_45725001_1 - 2.2 8.1 15.0 0.44 10.3 9.9 2.5 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.4 001170461.1_45725001_1 - 4.7 6.9 9.4 0.45 10.2 3.4 2.5 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain IBR PF01485.19 001170461.1_45725001_1 - 5.8 7.1 7.8 3.4e+02 1.4 7.8 2.8 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain TTL PF03133.13 001170533.1_45725001_3 - 8.8e-46 156.2 0.2 1.3e-45 155.6 0.2 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.4 001170533.1_45725001_3 - 1.9e-13 50.1 0.0 3.9e-07 29.4 0.0 2.4 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.4 001170533.1_45725001_3 - 6.8e-06 25.4 0.0 0.023 13.8 0.0 2.2 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp WD40 PF00400.30 001100718.1_45729001_1 - 9.8e-18 64.1 9.6 0.0016 19.1 0.1 6.5 5 0 0 5 5 5 5 WD domain, G-beta repeat Frtz PF11768.6 001100718.1_45729001_1 - 0.083 11.0 0.0 0.13 10.4 0.0 1.1 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Herpes_pp85 PF04637.10 001100718.1_45729001_1 - 0.5 8.6 6.5 0.89 7.8 6.5 1.3 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) IL12p40_C PF10420.7 001172967.1_09922001_1 - 1.3e-21 76.7 0.5 1.3e-21 76.7 0.5 2.6 3 0 0 3 3 3 1 Cytokine interleukin-12p40 C-terminus Ig_5 PF16681.3 001172967.1_09922001_1 - 4.1e-07 30.2 0.4 2.1e-06 28.0 0.1 2.3 1 1 1 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_3 PF13927.4 001172967.1_09922001_1 - 8.1e-06 26.2 6.5 2.9e-05 24.4 0.1 3.3 2 1 1 3 3 3 1 Immunoglobulin domain Ig_4 PF16680.3 001172967.1_09922001_1 - 3.1e-05 24.1 1.2 7.9e-05 22.8 0.1 2.3 2 1 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain fn3 PF00041.19 001172967.1_09922001_1 - 0.00026 21.1 1.5 0.00084 19.5 0.7 2.2 2 0 0 2 2 2 1 Fibronectin type III domain ig PF00047.23 001172967.1_09922001_1 - 0.0014 18.7 0.2 0.0014 18.7 0.2 2.9 2 1 1 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.4 001172967.1_09922001_1 - 0.014 15.6 2.4 0.065 13.5 0.0 2.9 2 1 1 3 3 3 0 Immunoglobulin domain V-set PF07686.15 001172967.1_09922001_1 - 0.034 14.2 5.8 6.3 6.9 0.0 3.8 3 1 1 4 4 4 0 Immunoglobulin V-set domain I-set PF07679.14 001172967.1_09922001_1 - 0.058 13.3 4.3 0.3 11.0 0.3 3.7 2 2 1 3 3 3 0 Immunoglobulin I-set domain FMO-like PF00743.17 001172947.1_09926001_1 - 3.3e-298 989.3 0.1 3.9e-298 989.0 0.1 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.4 001172947.1_09926001_1 - 2.2e-16 59.9 0.0 9.7e-12 44.6 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.4 001172947.1_09926001_1 - 2.2e-10 40.1 0.1 1.7e-07 30.6 0.0 3.0 2 1 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.12 001172947.1_09926001_1 - 3.8e-09 36.1 0.0 2.5e-08 33.4 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 001172947.1_09926001_1 - 1.1e-06 28.4 0.3 0.0056 16.2 0.0 3.0 3 0 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.4 001172947.1_09926001_1 - 0.0001 22.4 0.0 0.001 19.1 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.25 001172947.1_09926001_1 - 0.0088 16.4 1.3 1.3 9.5 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.4 001172947.1_09926001_1 - 0.1 12.5 2.1 3.1 7.7 0.1 3.2 3 1 0 3 3 3 0 FAD-NAD(P)-binding RNB PF00773.17 001172159.1_45727001_3 - 1.5e-101 339.8 0.0 2.2e-101 339.3 0.0 1.2 1 0 0 1 1 1 1 RNB domain Rrp44_CSD1 PF17216.1 001172159.1_45727001_3 - 2.6e-11 43.3 0.3 2.5e-10 40.1 0.0 2.4 2 1 0 2 2 2 1 Rrp44-like cold shock domain OB_RNB PF08206.9 001172159.1_45727001_3 - 0.022 14.3 0.0 0.045 13.3 0.0 1.5 1 0 0 1 1 1 0 Ribonuclease B OB domain Rrp44_S1 PF17215.1 001172159.1_45727001_3 - 0.096 12.5 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 S1 domain Adeno_Penton_B PF01686.15 001172159.1_45727001_3 - 0.16 10.2 0.0 0.31 9.3 0.0 1.3 1 0 0 1 1 1 0 Adenovirus penton base protein C2 PF00168.28 014677.4_26229001_3 - 7.3e-37 125.7 0.0 4e-19 68.7 0.0 2.4 2 0 0 2 2 2 2 C2 domain PDZ PF00595.22 014677.4_26229001_3 - 1.1e-05 25.6 0.0 2e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Asp PF00026.21 001172919.1_09928001_2 - 5.7e-39 134.2 0.0 6.7e-37 127.5 0.0 2.1 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.4 001172919.1_09928001_2 - 1.7e-10 40.7 0.0 2.5e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal TAXi_N PF14543.4 001172919.1_09928001_2 - 1.7e-05 25.1 0.0 0.0025 18.0 0.0 2.6 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal PAF-AH_p_II PF03403.11 001172886.1_09924001_3 - 3.3e-172 572.1 0.0 3.9e-172 571.8 0.0 1.0 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.5 001172886.1_09924001_3 - 2e-12 46.4 0.0 2.6e-10 39.5 0.0 2.5 1 1 1 2 2 2 2 Chlorophyllase enzyme Peptidase_S9 PF00326.19 001172886.1_09924001_3 - 9.3e-06 25.1 0.0 2.1e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Prolyl oligopeptidase family Chlorophyllase PF07224.9 001172886.1_09924001_3 - 1.3e-05 24.2 0.0 0.0019 17.2 0.0 2.2 2 0 0 2 2 2 2 Chlorophyllase Hydrolase_4 PF12146.6 001172886.1_09924001_3 - 2e-05 23.8 0.0 0.046 12.9 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.18 001172886.1_09924001_3 - 7.1e-05 22.4 0.0 0.00021 20.9 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001172886.1_09924001_3 - 0.00062 20.3 0.0 0.0024 18.4 0.0 1.9 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.5 001172886.1_09924001_3 - 0.0015 18.1 0.0 0.0032 17.1 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.16 001172886.1_09924001_3 - 0.0017 17.8 0.0 0.0038 16.7 0.0 1.5 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.14 001172886.1_09924001_3 - 0.018 14.7 0.0 0.83 9.3 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.11 001172886.1_09924001_3 - 0.18 11.5 0.0 0.31 10.7 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Zona_pellucida PF00100.21 001195720.1_37923001_1 - 1e-43 149.8 0.0 1.2e-43 149.6 0.0 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain LSM PF01423.20 001173384.1_45723001_2 - 1.5e-09 37.3 0.1 9.2e-05 21.9 0.0 2.5 2 0 0 2 2 2 2 LSM domain AAA PF00004.27 001171490.1_37923001_1 - 7.3e-40 136.3 0.0 1.5e-39 135.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.8 001171490.1_37923001_1 - 6.2e-10 38.8 0.3 1.1e-08 34.8 0.0 3.1 4 0 0 4 4 4 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.10 001171490.1_37923001_1 - 1.7e-05 24.1 0.0 3.1e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.12 001171490.1_37923001_1 - 2.4e-05 24.4 0.0 4.3e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.4 001171490.1_37923001_1 - 2.5e-05 24.3 0.0 4.7e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 001171490.1_37923001_1 - 3.1e-05 24.3 0.2 0.021 15.0 0.1 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.12 001171490.1_37923001_1 - 0.00019 21.3 0.2 0.0015 18.4 0.2 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.11 001171490.1_37923001_1 - 0.00027 19.9 0.0 0.00043 19.2 0.0 1.2 1 0 0 1 1 1 1 TIP49 C-terminus Mg_chelatase PF01078.19 001171490.1_37923001_1 - 0.00073 18.8 0.2 0.0015 17.8 0.2 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TsaE PF02367.15 001171490.1_37923001_1 - 0.0016 18.3 0.0 0.0029 17.5 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.15 001171490.1_37923001_1 - 0.0023 17.6 0.0 0.0051 16.5 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.4 001171490.1_37923001_1 - 0.0024 17.8 0.0 0.0061 16.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.4 001171490.1_37923001_1 - 0.0024 18.0 0.6 0.074 13.2 0.2 2.9 2 1 1 3 3 3 1 AAA domain AAA_18 PF13238.4 001171490.1_37923001_1 - 0.0089 16.4 0.6 0.039 14.3 0.6 2.1 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.4 001171490.1_37923001_1 - 0.0093 15.6 0.1 0.31 10.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain TPR_8 PF13181.4 001171490.1_37923001_1 - 0.016 15.3 0.3 2.1 8.7 0.1 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat ATPase PF06745.11 001171490.1_37923001_1 - 0.029 13.6 0.2 2.3 7.4 0.1 2.3 1 1 1 2 2 2 0 KaiC NACHT PF05729.10 001171490.1_37923001_1 - 0.044 13.6 0.1 0.11 12.3 0.1 1.7 1 0 0 1 1 1 0 NACHT domain AAA_28 PF13521.4 001171490.1_37923001_1 - 0.049 13.7 0.1 0.11 12.6 0.1 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.14 001171490.1_37923001_1 - 0.053 12.8 0.1 0.094 12.0 0.1 1.3 1 0 0 1 1 1 0 PhoH-like protein RNA_helicase PF00910.20 001171490.1_37923001_1 - 0.065 13.5 0.0 0.16 12.3 0.0 1.8 1 0 0 1 1 1 0 RNA helicase Guanylate_kin PF00625.19 001171490.1_37923001_1 - 0.12 11.9 0.0 0.45 10.1 0.0 1.9 2 0 0 2 2 2 0 Guanylate kinase AAA_30 PF13604.4 001171490.1_37923001_1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.4 001171490.1_37923001_1 - 0.15 11.5 0.3 0.49 9.8 0.3 2.0 1 1 1 2 2 2 0 AAA domain AAA_17 PF13207.4 001171490.1_37923001_1 - 0.25 11.7 1.9 0.25 11.6 0.0 2.1 2 0 0 2 2 1 0 AAA domain TPR_2 PF07719.15 001171490.1_37923001_1 - 1.9 8.7 3.5 32 4.8 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat B9-C2 PF07162.9 001034917.2_45725001_1 - 5.2e-46 156.8 0.0 1e-45 155.8 0.0 1.5 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein FUSC PF04632.10 001034917.2_45725001_1 - 0.016 13.7 0.1 0.024 13.1 0.1 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family LANC_like PF05147.11 001170331.1_26227001_3 - 6.4e-70 235.3 0.0 8.9e-70 234.9 0.0 1.1 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein Cyclin_N PF00134.21 024877.3_26224001_2 - 6.1e-27 93.8 0.0 1.2e-26 92.9 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 024877.3_26224001_2 - 0.0011 19.0 0.0 0.0024 17.8 0.0 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain OTOS PF15182.4 001172993.1_09922001_1 - 7.1e-36 121.8 3.6 9.2e-36 121.5 3.6 1.1 1 0 0 1 1 1 1 Otospiralin MEF2_binding PF09047.8 001201429.1_26229001_2 - 2.3e-23 81.6 6.3 1.1e-22 79.4 5.4 2.4 2 0 0 2 2 2 1 MEF2 binding TPR_2 PF07719.15 001201429.1_26229001_2 - 3.1e-09 36.1 17.5 0.35 11.0 0.1 7.9 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.4 001201429.1_26229001_2 - 4.4e-06 26.4 11.1 0.39 10.9 0.2 6.9 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.4 001201429.1_26229001_2 - 1.4e-05 25.5 4.1 7.3 7.3 0.0 6.2 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_11 PF13414.4 001201429.1_26229001_2 - 1.7e-05 24.2 3.0 0.0027 17.2 0.0 4.5 5 0 0 5 5 5 1 TPR repeat TPR_1 PF00515.26 001201429.1_26229001_2 - 2.6e-05 23.7 22.5 0.038 13.7 0.1 7.4 7 0 0 7 7 7 1 Tetratricopeptide repeat FAT PF02259.21 001201429.1_26229001_2 - 0.0053 15.9 1.2 0.011 14.8 0.0 2.0 2 0 0 2 2 2 1 FAT domain TPR_17 PF13431.4 001201429.1_26229001_2 - 0.017 15.3 12.9 7.5 7.1 0.0 6.7 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_7 PF13176.4 001201429.1_26229001_2 - 0.1 12.5 3.7 1.6 8.8 0.1 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.4 001201429.1_26229001_2 - 0.21 11.6 1.6 1 9.4 0.6 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.4 001201429.1_26229001_2 - 1.1 9.5 13.7 6.8 6.9 0.7 4.9 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.4 001201429.1_26229001_2 - 3.3 8.6 13.5 47 5.0 0.2 7.3 7 1 1 8 8 7 0 Tetratricopeptide repeat ABC_tran PF00005.25 001109883.2_45727001_1 - 2.2e-44 151.2 12.2 1.2e-22 80.8 0.0 4.0 5 0 0 5 5 3 2 ABC transporter SMC_N PF02463.17 001109883.2_45727001_1 - 8.3e-11 41.6 0.6 0.00049 19.5 0.0 4.3 2 2 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.4 001109883.2_45727001_1 - 1e-10 41.8 16.7 0.0023 17.7 0.0 5.2 5 1 0 6 6 6 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 001109883.2_45727001_1 - 1.7e-06 27.5 0.1 0.0042 16.6 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_tran_Xtn PF12848.5 001109883.2_45727001_1 - 1e-05 25.3 13.0 1e-05 25.3 13.0 5.1 5 0 0 5 5 3 1 ABC transporter DUF258 PF03193.14 001109883.2_45727001_1 - 1.5e-05 24.8 1.4 0.024 14.4 0.0 2.7 3 0 0 3 3 2 2 Protein of unknown function, DUF258 NACHT PF05729.10 001109883.2_45727001_1 - 2e-05 24.4 0.0 0.065 13.0 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_16 PF13191.4 001109883.2_45727001_1 - 3.7e-05 24.0 3.0 0.12 12.6 0.1 2.9 3 0 0 3 3 2 2 AAA ATPase domain AAA_18 PF13238.4 001109883.2_45727001_1 - 3.8e-05 24.1 5.1 0.038 14.4 0.0 4.2 3 1 0 4 4 3 1 AAA domain AAA PF00004.27 001109883.2_45727001_1 - 4.7e-05 23.7 0.1 0.13 12.5 0.0 3.1 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.4 001109883.2_45727001_1 - 6.5e-05 22.8 0.0 0.2 11.6 0.0 3.1 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.4 001109883.2_45727001_1 - 6.7e-05 22.6 2.1 0.28 10.7 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.4 001109883.2_45727001_1 - 0.00015 21.4 0.0 0.75 9.3 0.0 3.4 2 2 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.21 001109883.2_45727001_1 - 0.00025 21.0 0.2 0.077 13.0 0.0 3.0 3 0 0 3 3 3 1 50S ribosome-binding GTPase AAA_5 PF07728.12 001109883.2_45727001_1 - 0.00034 20.5 0.5 0.94 9.3 0.1 2.9 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) RNA_helicase PF00910.20 001109883.2_45727001_1 - 0.00041 20.6 0.0 1.4 9.2 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_28 PF13521.4 001109883.2_45727001_1 - 0.00081 19.5 6.6 0.12 12.4 0.1 3.2 3 0 0 3 3 2 2 AAA domain AAA_22 PF13401.4 001109883.2_45727001_1 - 0.0009 19.4 4.5 0.33 11.1 0.1 3.6 3 1 0 3 3 3 2 AAA domain AAA_23 PF13476.4 001109883.2_45727001_1 - 0.001 19.5 0.0 0.001 19.5 0.0 5.8 5 1 0 5 5 3 2 AAA domain AAA_33 PF13671.4 001109883.2_45727001_1 - 0.0018 18.3 0.0 2.7 8.0 0.0 3.1 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.4 001109883.2_45727001_1 - 0.0021 17.5 0.2 1.1 8.7 0.0 3.0 3 0 0 3 3 3 1 AAA domain NTPase_1 PF03266.13 001109883.2_45727001_1 - 0.003 17.4 0.9 1.9 8.3 0.1 2.9 3 0 0 3 3 3 1 NTPase Roc PF08477.11 001109883.2_45727001_1 - 0.0032 17.6 0.0 2.8 8.1 0.0 2.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.17 001109883.2_45727001_1 - 0.0051 16.3 0.2 0.41 10.1 0.0 2.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.20 001109883.2_45727001_1 - 0.021 14.3 0.1 2 7.9 0.0 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain NB-ARC PF00931.20 001109883.2_45727001_1 - 0.047 12.6 1.6 1.8 7.4 0.0 2.8 3 0 0 3 3 3 0 NB-ARC domain IstB_IS21 PF01695.15 001109883.2_45727001_1 - 0.054 13.1 0.0 4.8 6.8 0.0 2.6 2 0 0 2 2 2 0 IstB-like ATP binding protein ATPase_2 PF01637.16 001109883.2_45727001_1 - 1.5 8.5 0.0 1.5 8.5 0.0 4.0 5 0 0 5 5 3 0 ATPase domain predominantly from Archaea Glyco_hydro_20 PF00728.20 001142562.2_45724001_3 - 4.2e-10 39.4 0.0 6.9e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Ion_trans PF00520.29 001172821.1_09925001_1 - 1.5e-25 89.7 12.2 2.1e-25 89.2 12.2 1.1 1 0 0 1 1 1 1 Ion transport protein KCNQ_channel PF03520.12 001172821.1_09925001_1 - 7.3e-25 87.8 1.3 1.6e-24 86.7 1.3 1.5 1 0 0 1 1 1 1 KCNQ voltage-gated potassium channel Ion_trans_2 PF07885.14 001172821.1_09925001_1 - 1.5e-11 43.9 6.7 1.5e-11 43.9 6.7 2.4 2 0 0 2 2 2 1 Ion channel DUF4613 PF15390.4 001172821.1_09925001_1 - 0.003 15.9 0.0 0.0041 15.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4613) RRM_1 PF00076.20 001171080.1_26229001_1 - 3.4e-09 36.3 0.0 6.9e-09 35.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cystatin PF00031.19 003650.3_26222001_1 - 1.7e-16 60.1 0.1 2.5e-16 59.6 0.1 1.2 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.3 003650.3_26222001_1 - 0.0036 17.5 0.0 0.0056 16.9 0.0 1.2 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor Spp-24 PF07448.9 003650.3_26222001_1 - 0.004 17.2 0.0 0.008 16.2 0.0 1.5 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain G6B PF15096.4 138273.2_26225001_2 - 3.4e-99 331.0 7.6 9.7e-74 247.8 2.8 2.2 1 1 1 2 2 2 2 G6B family Trypsin PF00089.24 001164003.1_49826001_2 - 3.5e-68 229.6 0.2 4.6e-68 229.2 0.2 1.2 1 0 0 1 1 1 1 Trypsin Gla PF00594.18 001164003.1_49826001_2 - 2e-20 72.6 12.0 3.7e-20 71.7 12.0 1.5 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FXa_inhibition PF14670.4 001164003.1_49826001_2 - 2.5e-08 33.9 22.0 2.6e-08 33.9 7.8 3.0 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site EGF PF00008.25 001164003.1_49826001_2 - 4.7e-07 29.9 6.4 4.7e-07 29.9 6.4 3.4 3 0 0 3 3 3 1 EGF-like domain Trypsin_2 PF13365.4 001164003.1_49826001_2 - 0.00038 21.2 0.1 0.00074 20.3 0.1 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain cEGF PF12662.5 001164003.1_49826001_2 - 0.00058 19.6 7.5 0.0032 17.2 1.6 3.1 2 0 0 2 2 2 1 Complement Clr-like EGF-like DUF1986 PF09342.9 001164003.1_49826001_2 - 0.00096 19.4 0.0 0.002 18.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) hEGF PF12661.5 001164003.1_49826001_2 - 0.013 16.0 3.9 0.013 16.0 3.9 3.7 3 1 0 3 3 3 0 Human growth factor-like EGF Calsarcin PF05556.9 001166208.1_26229001_3 - 3.1e-07 30.0 0.0 0.0017 17.7 0.0 2.5 2 0 0 2 2 2 2 Calcineurin-binding protein (Calsarcin) UVR PF02151.17 145082.2_45729001_1 - 0.0022 17.6 19.1 0.055 13.1 4.5 2.6 2 0 0 2 2 2 2 UvrB/uvrC motif CLASP_N PF12348.6 145082.2_45729001_1 - 0.037 13.5 0.1 0.079 12.4 0.1 1.5 1 0 0 1 1 1 0 CLASP N terminal PRP21_like_P PF12230.6 145082.2_45729001_1 - 0.082 12.6 6.6 3.4 7.3 0.1 2.9 1 1 1 2 2 2 0 Pre-mRNA splicing factor PRP21 like protein zf-Di19 PF05605.10 145082.2_45729001_1 - 0.17 12.1 9.6 0.1 12.8 4.2 2.7 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding TACC PF05010.12 001004415.2_45729001_1 - 6.7e-84 280.5 33.5 1.1e-83 279.9 33.5 1.3 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC) Skp1_POZ PF03931.13 001004415.2_45729001_1 - 0.042 13.9 0.5 0.095 12.7 0.5 1.6 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain Pkinase PF00069.23 001108517.2_45727001_1 - 3.2e-132 439.6 0.0 2.2e-66 223.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 001108517.2_45727001_1 - 1.7e-60 204.4 0.0 1.2e-29 103.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.4 001108517.2_45727001_1 - 3.6e-11 42.8 0.0 0.00023 20.4 0.0 2.9 2 1 1 3 3 3 2 Kinase-like APH PF01636.21 001108517.2_45727001_1 - 1.3e-09 38.2 7.1 0.00022 21.1 0.0 4.2 2 2 2 4 4 4 4 Phosphotransferase enzyme family Kdo PF06293.12 001108517.2_45727001_1 - 2.3e-07 30.3 0.1 0.00098 18.4 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 001108517.2_45727001_1 - 5.9e-06 25.9 0.1 0.00055 19.4 0.0 2.2 2 0 0 2 2 2 1 RIO1 family Pkinase_C PF00433.22 001108517.2_45727001_1 - 2.2e-05 24.9 0.0 5.2e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain FTA2 PF13095.4 001108517.2_45727001_1 - 0.0028 17.2 0.1 4.8 6.6 0.0 3.0 3 0 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.18 001108517.2_45727001_1 - 0.027 13.9 0.0 0.12 11.9 0.0 1.9 2 0 0 2 2 2 0 Choline/ethanolamine kinase Sushi PF00084.18 001105754.2_45728001_3 - 6.6e-46 154.6 25.0 6.3e-11 42.6 2.0 5.4 5 0 0 5 5 5 5 Sushi repeat (SCR repeat) CUB PF00431.18 001105754.2_45728001_3 - 3.9e-34 117.2 0.0 2e-15 56.9 0.0 3.4 3 0 0 3 3 3 3 CUB domain cEGF PF12662.5 001105754.2_45728001_3 - 2.1 8.2 11.1 14 5.6 0.1 5.1 5 0 0 5 5 5 0 Complement Clr-like EGF-like DAO PF01266.22 001173047.1_09923001_2 - 4.3e-38 131.6 0.1 5.2e-38 131.4 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.25 001173047.1_09923001_2 - 0.014 15.8 0.0 1.2 9.6 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.12 001173047.1_09923001_2 - 0.033 13.6 0.2 0.061 12.8 0.2 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Dpy-30 PF05186.11 173117.2_45722001_1 - 5.6e-21 73.8 0.4 8.3e-21 73.3 0.4 1.3 1 0 0 1 1 1 1 Dpy-30 motif RIIa PF02197.15 173117.2_45722001_1 - 0.0093 15.5 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Sulfotransfer_1 PF00685.25 001173022.1_09923001_2 - 2.4e-92 309.1 0.4 2.4e-92 309.1 0.4 1.4 2 0 0 2 2 2 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 001173022.1_09923001_2 - 0.0034 17.7 0.0 0.15 12.3 0.0 2.3 2 0 0 2 2 2 1 Sulfotransferase family PH PF00169.27 001170799.1_45724001_3 - 1.3e-16 60.9 2.9 6.3e-16 58.7 1.4 2.6 2 0 0 2 2 2 1 PH domain PH_9 PF15410.4 001170799.1_45724001_3 - 8.9e-06 25.9 4.2 0.042 14.1 3.5 4.0 3 1 0 3 3 3 1 Pleckstrin homology domain SPX PF03105.17 001170799.1_45724001_3 - 8 6.2 15.7 12 5.6 15.7 1.3 1 0 0 1 1 1 0 SPX domain 7tm_4 PF13853.4 001005519.2_26222001_1 - 2.9e-43 148.5 22.8 3.7e-43 148.1 22.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001005519.2_26222001_1 - 5.6e-25 88.0 16.1 8.4e-25 87.4 16.1 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) ECSCR PF15820.3 001005519.2_26222001_1 - 0.61 9.8 5.4 1 9.1 4.7 1.7 1 1 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator zf-UBR PF02207.18 001178072.1_45729001_1 - 1.2e-21 76.5 12.3 1.2e-21 76.5 12.3 3.9 5 0 0 5 5 5 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.15 001178072.1_45729001_1 - 3.6e-21 74.6 0.6 8.4e-21 73.4 0.6 1.7 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS Skp1 PF01466.17 001173015.1_09923001_3 - 3.8e-30 103.6 1.9 6.2e-30 102.9 1.9 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.13 001173015.1_09923001_3 - 1.3e-29 102.0 0.2 2.6e-29 101.1 0.2 1.5 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain VPS13_mid_rpt PF16910.3 018080.3_26229001_2 - 4.1e-93 311.0 32.6 2.3e-68 230.0 3.2 7.6 5 2 0 5 5 5 4 Repeating coiled region of VPS13 VPS13 PF16908.3 018080.3_26229001_2 - 4e-66 223.0 18.5 1.9e-65 220.8 4.6 4.9 6 0 0 6 6 6 2 Vacuolar sorting-associated protein 13, N-terminal VPS13_C PF16909.3 018080.3_26229001_2 - 1.4e-64 217.0 4.2 6.9e-62 208.2 0.1 3.0 2 1 1 3 3 3 3 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.5 018080.3_26229001_2 - 3.6e-36 123.7 4.1 5.6e-36 123.0 0.9 3.2 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 SHR-BD PF06650.10 018080.3_26229001_2 - 3.9e-31 108.3 0.0 1.3e-29 103.3 0.0 2.8 3 0 0 3 3 3 1 SHR-binding domain of vacuolar-sorting associated protein 13 ATG_C PF09333.9 018080.3_26229001_2 - 5.3e-10 39.4 0.1 2.9e-09 37.0 0.0 2.4 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain WWE PF02825.18 018080.3_26229001_2 - 0.0011 19.3 0.1 0.0048 17.3 0.1 2.2 1 0 0 1 1 1 1 WWE domain 7tm_1 PF00001.19 001164589.1_40422001_1 - 4.2e-31 108.0 23.2 4.9e-29 101.2 23.2 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001164589.1_40422001_1 - 5.6e-13 49.1 7.0 5.6e-13 49.1 7.0 2.9 1 1 0 3 3 3 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001164589.1_40422001_1 - 3.7e-08 32.9 17.6 3e-07 29.9 17.6 2.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Pox_A14 PF05767.10 001164589.1_40422001_1 - 0.013 15.5 1.4 0.028 14.4 0.6 2.0 1 1 0 1 1 1 0 Poxvirus virion envelope protein A14 7TM_GPCR_Srx PF10328.7 001164589.1_40422001_1 - 0.16 11.1 19.6 0.0086 15.3 10.6 2.5 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx UBA PF00627.29 001034937.2_45725001_3 - 8.3e-12 44.6 0.6 1.7e-11 43.6 0.6 1.6 1 0 0 1 1 1 1 UBA/TS-N domain DER1 PF04511.13 001034937.2_45725001_3 - 0.04 13.5 2.6 0.068 12.7 2.6 1.4 1 0 0 1 1 1 0 Der1-like family Rhomboid PF01694.20 001034937.2_45725001_3 - 0.056 13.3 2.6 0.13 12.1 2.6 1.6 1 0 0 1 1 1 0 Rhomboid family EF-hand_1 PF00036.30 019855.4_26224001_1 - 1.2e-26 90.1 10.5 8.7e-08 31.1 0.2 4.3 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.4 019855.4_26224001_1 - 4.8e-25 85.2 1.6 2.9e-08 32.9 0.1 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.4 019855.4_26224001_1 - 4.1e-23 81.5 4.3 6.6e-14 52.0 0.2 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 019855.4_26224001_1 - 1.2e-19 69.7 6.7 1.9e-11 43.4 0.1 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 019855.4_26224001_1 - 8.7e-16 56.5 9.1 3e-05 23.2 0.2 3.8 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.4 019855.4_26224001_1 - 5.8e-06 26.4 0.2 0.1 12.8 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 019855.4_26224001_1 - 0.0031 17.3 0.2 0.0085 15.9 0.0 1.8 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 019855.4_26224001_1 - 0.055 13.6 0.0 0.76 10.0 0.0 2.1 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.11 019855.4_26224001_1 - 0.063 13.1 0.0 0.19 11.5 0.0 1.7 2 0 0 2 2 2 0 Tellurite resistance protein TerB Dockerin_1 PF00404.16 019855.4_26224001_1 - 7.2 6.6 9.3 20 5.2 4.1 2.5 2 0 0 2 2 2 0 Dockerin type I repeat AMP-binding PF00501.26 001172908.1_09928001_3 - 4.8e-110 367.9 0.0 6e-110 367.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 001172908.1_09928001_3 - 9e-06 26.5 0.0 1.9e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Mito_carr PF00153.25 001173334.1_45725001_1 - 1.1e-68 227.1 1.8 5.6e-22 77.3 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein P53 PF00870.16 001172740.1_09925001_3 - 2.2e-112 373.2 1.1 3.1e-112 372.7 1.1 1.2 1 0 0 1 1 1 1 P53 DNA-binding domain P53_tetramer PF07710.9 001172740.1_09925001_3 - 1.8e-16 59.0 2.0 4e-16 57.9 2.0 1.6 1 0 0 1 1 1 1 P53 tetramerisation motif P53_TAD PF08563.9 001172740.1_09925001_3 - 3.9e-13 48.3 3.2 9.9e-13 47.0 3.2 1.8 1 0 0 1 1 1 1 P53 transactivation motif GTP_EFTU PF00009.25 001185044.1_08027001_3 - 7e-65 218.1 0.0 9.7e-65 217.6 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.16 001185044.1_08027001_3 - 3.1e-34 117.2 0.1 9.5e-34 115.6 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.22 001185044.1_08027001_3 - 8.8e-23 80.0 0.0 2e-22 78.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.4 001185044.1_08027001_3 - 2.4e-13 49.8 0.0 5.3e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.23 001185044.1_08027001_3 - 3.3e-13 49.7 0.2 1.6e-12 47.5 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 001185044.1_08027001_3 - 1.4e-05 25.0 0.1 3.3e-05 23.8 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RAI1 PF08652.9 212497.2_45723001_3 - 6.2e-22 77.4 0.0 1.6e-21 76.1 0.0 1.7 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease ASC PF00858.22 001173012.1_09924001_1 - 1.7e-102 343.3 9.6 1.9e-102 343.1 9.6 1.0 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Laminin_EGF PF00053.22 001100640.1_45729001_2 - 1.6e-37 127.3 163.1 3e-09 36.7 15.5 9.2 10 0 0 10 10 10 8 Laminin EGF domain Laminin_B PF00052.16 001100640.1_45729001_2 - 3.3e-30 104.6 0.8 4.7e-28 97.6 0.0 3.4 3 0 0 3 3 3 1 Laminin B (Domain IV) EzrA PF06160.10 001100640.1_45729001_2 - 0.008 14.3 27.3 0.043 11.9 14.3 2.4 2 0 0 2 2 2 2 Septation ring formation regulator, EzrA TGFb_propeptide PF00688.16 001173023.1_09924001_2 - 1.8e-36 126.0 0.0 2.3e-36 125.6 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 001173023.1_09924001_2 - 1.5e-22 80.3 1.7 3.1e-22 79.3 1.7 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain zf-H2C2_2 PF13465.4 001167583.2_26229001_2 - 3.2e-36 122.0 136.4 9.8e-08 32.0 0.2 20.9 21 1 0 21 21 21 12 Zinc-finger double domain zf-C2H2 PF00096.24 001167583.2_26229001_2 - 1.1e-34 116.8 160.0 7.9e-05 22.8 3.3 19.5 19 0 0 19 19 19 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001167583.2_26229001_2 - 5.8e-31 104.4 153.6 0.0055 17.3 2.9 19.5 19 0 0 19 19 19 16 C2H2-type zinc finger zf-H2C2_5 PF13909.4 001167583.2_26229001_2 - 4.5e-29 99.7 115.7 3.9e-09 36.0 0.2 14.9 16 1 0 16 16 16 9 C2H2-type zinc-finger domain zf-Di19 PF05605.10 001167583.2_26229001_2 - 2.8e-14 53.0 90.3 0.0032 17.6 0.7 12.3 11 1 1 12 12 12 8 Drought induced 19 protein (Di19), zinc-binding Rad50_zn_hook PF04423.12 001167583.2_26229001_2 - 0.0081 15.9 5.7 0.2 11.4 0.1 4.1 3 0 0 3 3 3 1 Rad50 zinc hook motif zf-met PF12874.5 001167583.2_26229001_2 - 0.022 15.0 0.4 0.022 15.0 0.4 14.6 16 0 0 16 16 16 0 Zinc-finger of C2H2 type eIF_4EBP PF05456.9 001202552.1_45722001_3 - 7.8e-37 125.6 0.8 1.4e-36 124.8 0.8 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Cpn60_TCP1 PF00118.22 001166284.1_26224001_3 - 1e-130 436.5 1.9 1.2e-130 436.3 1.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family G-alpha PF00503.18 001172954.1_09923001_1 - 1.3e-125 419.1 2.4 1.5e-125 418.9 2.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 001172954.1_09923001_1 - 4e-17 62.1 2.2 8.9e-13 47.9 0.1 2.8 3 1 0 3 3 3 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001172954.1_09923001_1 - 1.5e-05 24.3 1.7 0.031 13.5 0.7 2.4 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.11 001172954.1_09923001_1 - 0.00011 22.3 0.2 0.7 10.0 0.1 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 001172954.1_09923001_1 - 0.017 15.4 0.0 0.029 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain DUF261 PF03196.11 001172954.1_09923001_1 - 0.028 14.4 0.4 2.8 7.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF261 Ras PF00071.20 001172954.1_09923001_1 - 0.054 13.0 1.6 4.3 6.8 0.9 2.5 2 1 0 2 2 2 0 Ras family TniB PF05621.9 001172954.1_09923001_1 - 0.089 11.8 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA_29 PF13555.4 001172954.1_09923001_1 - 0.11 12.1 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Chon_Sulph_att PF06566.9 001206945.1_26225001_3 - 3.3e-120 400.5 24.8 4.9e-120 399.9 24.8 1.2 1 0 0 1 1 1 1 Chondroitin sulphate attachment domain Neural_ProG_Cyt PF06567.9 001206945.1_26225001_3 - 8.6e-69 229.1 1.4 1.6e-68 228.3 1.4 1.4 1 0 0 1 1 1 1 Neural chondroitin sulphate proteoglycan cytoplasmic domain Pkinase_Tyr PF07714.15 001162411.1_45729001_3 - 7.8e-96 320.2 0.0 1.1e-95 319.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.17 001162411.1_45729001_3 - 5.4e-73 244.7 0.1 8.7e-73 244.0 0.1 1.3 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.23 001162411.1_45729001_3 - 6.4e-45 153.4 0.0 1e-44 152.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.19 001162411.1_45729001_3 - 1.4e-31 108.5 1.0 5.4e-15 55.4 0.2 2.7 2 0 0 2 2 2 2 Fibronectin type III domain EphA2_TM PF14575.4 001162411.1_45729001_3 - 9e-24 84.0 0.1 9e-24 84.0 0.1 1.9 2 0 0 2 2 1 1 Ephrin type-A receptor 2 transmembrane domain SAM_2 PF07647.15 001162411.1_45729001_3 - 1.4e-19 69.8 0.0 2.6e-19 68.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 001162411.1_45729001_3 - 2e-17 63.2 0.0 3.6e-17 62.4 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ephrin_rec_like PF07699.11 001162411.1_45729001_3 - 7.2e-05 22.3 5.8 7.2e-05 22.3 5.8 2.9 2 2 1 3 3 3 1 Putative ephrin-receptor like Pur_ac_phosph_N PF16656.3 001162411.1_45729001_3 - 0.0015 18.9 1.1 0.63 10.5 0.2 2.5 1 1 1 2 2 2 2 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.3 001162411.1_45729001_3 - 0.0035 17.3 0.3 1.2 9.2 0.0 2.7 3 0 0 3 3 3 1 Fibronectin type III domain SusE PF14292.4 001162411.1_45729001_3 - 0.0069 16.6 0.5 0.25 11.6 0.0 2.3 2 0 0 2 2 2 1 SusE outer membrane protein Na_K-ATPase PF00287.16 001172918.2_09923001_1 - 6e-97 324.1 0.0 7.5e-97 323.8 0.0 1.1 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain XPG_I_2 PF12813.5 001107466.3_45729001_3 - 0.0014 18.1 0.0 0.0028 17.0 0.0 1.4 1 0 0 1 1 1 1 XPG domain containing An_peroxidase PF03098.13 001281401.1_31326001_1 - 1.7e-179 597.7 0.0 2.1e-179 597.3 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase RimK PF08443.9 001246515.1_39725001_1 - 3.7e-42 143.9 0.0 5.9e-42 143.3 0.0 1.3 1 0 0 1 1 1 1 RimK-like ATP-grasp domain GSH-S_ATP PF02955.14 001246515.1_39725001_1 - 3e-11 42.9 0.0 5e-11 42.2 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATP-grasp_3 PF02655.12 001246515.1_39725001_1 - 7.8e-07 29.1 0.0 1.2e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.4 001246515.1_39725001_1 - 2.7e-06 26.7 2.3 0.039 13.1 0.3 3.1 1 1 1 2 2 2 2 Sugar-transfer associated ATP-grasp ATPgrasp_Ter PF15632.4 001246515.1_39725001_1 - 0.0018 16.9 0.0 0.0027 16.3 0.0 1.1 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.20 001246515.1_39725001_1 - 0.0058 16.1 0.0 0.0092 15.4 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.11 001246515.1_39725001_1 - 0.068 12.6 0.0 0.19 11.1 0.0 1.6 2 0 0 2 2 2 0 D-ala D-ala ligase C-terminus CPSase_L_D2 PF02786.15 001246515.1_39725001_1 - 0.082 12.3 0.0 0.23 10.8 0.0 1.7 1 1 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Ldl_recept_a PF00057.16 001278865.1_37927001_1 - 1.3e-90 297.1 142.8 1.7e-14 53.6 13.9 8.6 8 0 0 8 8 8 7 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.15 001278865.1_37927001_1 - 9.1e-68 224.4 10.8 4.9e-14 52.4 0.7 5.9 6 0 0 6 6 6 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 001278865.1_37927001_1 - 1.7e-20 72.8 41.0 5.4e-09 36.0 1.9 5.6 3 2 1 4 4 4 3 Coagulation Factor Xa inhibitory site cEGF PF12662.5 001278865.1_37927001_1 - 9.6e-12 44.5 20.9 6.5e-06 25.8 1.2 5.3 4 0 0 4 4 4 3 Complement Clr-like EGF-like EGF_CA PF07645.13 001278865.1_37927001_1 - 3.8e-08 33.3 5.1 3.8e-08 33.3 5.1 9.2 6 2 2 8 8 8 2 Calcium-binding EGF domain SGL PF08450.10 001278865.1_37927001_1 - 1.9e-07 30.8 0.4 0.021 14.3 0.1 2.9 2 1 1 3 3 3 2 SMP-30/Gluconolaconase/LRE-like region hEGF PF12661.5 001278865.1_37927001_1 - 0.036 14.6 0.2 0.036 14.6 0.2 9.5 8 2 0 8 8 8 0 Human growth factor-like EGF DUF5050 PF16472.3 001278865.1_37927001_1 - 0.046 12.8 0.0 6.1 5.8 0.1 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF5050) EMP24_GP25L PF01105.22 001281688.1_31322001_1 - 9e-48 162.5 0.0 1e-47 162.3 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD NDUFA12 PF05071.14 001279616.1_24221001_1 - 1.2e-30 106.0 5.8 1.5e-30 105.7 5.8 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 PT-VENN PF04829.11 001281701.1_31325001_1 - 4.6 7.3 8.7 8.7 6.4 8.7 1.4 1 0 0 1 1 1 0 Pre-toxin domain with VENN motif Caudal_act PF04731.10 001281701.1_31325001_2 - 6.1e-35 120.4 13.6 1.3e-34 119.3 13.6 1.6 1 0 0 1 1 1 1 Caudal like protein activation region Homeobox PF00046.27 001281701.1_31325001_2 - 2.5e-20 71.9 2.2 4.3e-20 71.1 2.2 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001281701.1_31325001_2 - 0.0043 16.8 0.6 0.011 15.5 0.6 1.7 1 0 0 1 1 1 1 Homeobox KN domain SBF_like PF13593.4 001282109.1_32928001_1 - 1e-44 153.0 12.1 1.6e-44 152.3 12.1 1.2 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) SBF PF01758.14 001282109.1_32928001_1 - 1.6e-07 31.1 2.4 1.6e-07 31.1 2.4 1.8 2 0 0 2 2 2 1 Sodium Bile acid symporter family SBF_like PF13593.4 001282109.1_32928001_2 - 6.1e-17 61.8 2.8 8.5e-17 61.3 2.8 1.1 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) Trypsin PF00089.24 001270780.1_26222001_3 - 1.2e-46 159.2 0.2 3.1e-32 112.1 0.0 2.1 1 1 1 2 2 2 2 Trypsin Trypsin_2 PF13365.4 001270780.1_26222001_3 - 0.0007 20.4 0.0 0.013 16.2 0.0 2.0 1 1 1 2 2 2 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001270780.1_26222001_3 - 0.002 18.4 0.0 0.0052 17.0 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Steroid_dh PF02544.14 001281706.1_31323001_3 - 3.6e-19 69.1 12.3 3.6e-19 69.1 12.3 1.8 1 1 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase Troponin PF00992.18 001270665.1_45723001_3 - 5.3e-33 114.0 34.3 5.3e-33 114.0 34.3 3.1 2 1 1 3 3 3 2 Troponin DUF4381 PF14316.4 001271086.1_45728001_1 - 0.018 15.2 0.1 0.035 14.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) ubiquitin PF00240.21 001281950.1_31321001_3 - 2.9e-06 26.8 0.1 6.8e-06 25.6 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.4 001281950.1_31321001_3 - 0.00023 21.4 0.1 0.0015 18.8 0.1 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain CHORD PF04968.10 001108245.2_45723001_2 - 2.5e-52 175.3 12.3 1.3e-27 96.1 1.8 3.0 3 0 0 3 3 3 2 CHORD CS PF04969.14 001108245.2_45723001_2 - 5.4e-12 46.4 0.1 8.7e-12 45.8 0.1 1.3 1 0 0 1 1 1 1 CS domain zf-tcix PF14952.4 001108245.2_45723001_2 - 0.017 14.6 0.6 7.5 6.1 0.1 2.6 2 0 0 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding BTK PF00779.17 001108245.2_45723001_2 - 8.1 6.2 20.1 0.27 11.0 0.8 3.9 5 1 0 5 5 5 0 BTK motif adh_short_C2 PF13561.4 001281411.1_31322001_2 - 6.5e-55 186.1 1.1 7.7e-55 185.9 1.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.23 001281411.1_31322001_2 - 3e-50 170.3 1.5 3.6e-50 170.0 1.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.8 001281411.1_31322001_2 - 1.5e-07 31.3 1.8 2.3e-07 30.8 1.8 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.19 001281411.1_31322001_2 - 3.3e-06 26.6 0.2 4.9e-05 22.8 0.2 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.4 001281411.1_31322001_2 - 8.6e-05 22.4 1.2 0.00013 21.8 1.2 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Shikimate_DH PF01488.18 001281411.1_31322001_2 - 0.00086 19.3 0.0 0.0015 18.4 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase RmlD_sub_bind PF04321.15 001281411.1_31322001_2 - 0.0082 15.1 0.3 0.013 14.5 0.3 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.11 001281411.1_31322001_2 - 0.012 15.0 0.2 0.02 14.4 0.2 1.3 1 0 0 1 1 1 0 NmrA-like family Sacchrp_dh_NADP PF03435.16 001281411.1_31322001_2 - 0.043 13.9 0.1 0.079 13.1 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DUF1776 PF08643.8 001281411.1_31322001_2 - 0.082 12.1 0.1 0.12 11.6 0.1 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) 2-Hacid_dh_C PF02826.17 001281411.1_31322001_2 - 0.098 11.9 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NDUFB10 PF10249.7 001279654.1_24222001_1 - 3.2e-47 160.0 17.9 3.8e-47 159.8 17.9 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 NDUF_B12 PF08122.10 001279717.1_24221001_1 - 2.1e-23 82.0 2.0 3.9e-23 81.1 2.0 1.5 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family FOP_dimer PF09398.8 001283512.1_29524001_3 - 3.1e-28 97.7 0.0 8e-28 96.4 0.0 1.7 1 0 0 1 1 1 1 FOP N terminal dimerisation domain LisH_2 PF16045.3 001283512.1_29524001_3 - 2.4e-07 29.5 1.4 4.1e-07 28.8 0.1 1.9 2 0 0 2 2 2 1 LisH adh_short PF00106.23 017235.3_45724001_1 - 1.6e-26 92.8 0.0 1.2e-24 86.8 0.0 2.3 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 017235.3_45724001_1 - 5.5e-13 48.9 0.0 3.7e-07 29.8 0.0 2.3 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 017235.3_45724001_1 - 4.8e-06 26.5 0.0 7.8e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.19 017235.3_45724001_1 - 0.019 14.3 0.0 1.1 8.6 0.0 2.1 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 017235.3_45724001_1 - 0.15 11.3 0.0 0.96 8.6 0.0 1.9 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Eno-Rase_NADH_b PF12242.6 017235.3_45724001_1 - 0.15 11.7 0.1 0.31 10.7 0.1 1.4 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Pep_M12B_propep PF01562.17 001271445.1_45729001_1 - 1.4e-32 112.7 0.0 2.3e-32 112.0 0.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_spacer1 PF05986.12 001271445.1_45729001_1 - 1.3e-25 89.5 0.0 2e-25 88.9 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Reprolysin PF01421.17 001271445.1_45729001_1 - 6.5e-24 84.8 0.1 1.9e-23 83.3 0.1 1.8 1 1 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.4 001271445.1_45729001_1 - 2.9e-13 50.3 0.1 5.4e-13 49.4 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 TSP_1 PF00090.17 001271445.1_45729001_1 - 5.6e-12 45.6 91.6 2.8e-06 27.3 10.0 7.6 8 0 0 8 8 8 5 Thrombospondin type 1 domain Reprolysin_3 PF13582.4 001271445.1_45729001_1 - 2.4e-11 44.1 0.1 3.7e-11 43.5 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like PLAC PF08686.9 001271445.1_45729001_1 - 2e-09 37.9 11.4 8.3e-09 35.9 11.4 2.2 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain Reprolysin_2 PF13574.4 001271445.1_45729001_1 - 2.9e-09 37.0 0.1 5.2e-09 36.1 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 001271445.1_45729001_1 - 9.6e-07 28.5 0.3 2.2e-06 27.3 0.3 1.5 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.3 001271445.1_45729001_1 - 0.19 10.7 0.2 0.29 10.1 0.2 1.1 1 0 0 1 1 1 0 Met-zincin bZIP_1 PF00170.19 017334.2_45727001_1 - 7.1e-20 70.8 10.5 1.1e-19 70.1 10.5 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 017334.2_45727001_1 - 1.7e-06 27.9 11.2 2.6e-06 27.3 11.2 1.2 1 0 0 1 1 1 1 Basic region leucine zipper DUF3072 PF11272.6 017334.2_45727001_1 - 0.0068 16.2 0.1 5.2 6.9 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF3072) bZIP_Maf PF03131.15 017334.2_45727001_1 - 0.027 14.9 6.4 0.047 14.1 6.4 1.2 1 0 0 1 1 1 0 bZIP Maf transcription factor Meckelin PF09773.7 001107916.2_45729001_3 - 0 1157.6 6.1 0 1157.6 6.1 2.0 2 0 0 2 2 2 2 Meckelin (Transmembrane protein 67) IQ PF00612.25 001279606.1_24229001_1 - 1.5e-135 428.4 512.8 0.00027 20.3 0.4 70.3 71 1 2 73 73 73 59 IQ calmodulin-binding motif ASH PF15780.3 001279606.1_24229001_1 - 5e-33 113.1 1.4 9.1e-33 112.2 0.0 2.2 2 0 0 2 2 2 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin CH PF00307.29 001279606.1_24229001_1 - 4.2e-13 49.3 11.8 2.2e-08 34.1 0.0 6.5 6 1 0 6 6 6 2 Calponin homology (CH) domain CAMSAP_CH PF11971.6 001279606.1_24229001_1 - 1.9e-06 27.5 0.0 7.4e-06 25.6 0.0 2.0 1 0 0 1 1 1 1 CAMSAP CH domain DUF5036 PF16439.3 001279606.1_24229001_1 - 0.031 13.9 2.0 7.9 6.0 0.1 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5036) CH_2 PF06294.9 001279606.1_24229001_1 - 0.32 11.0 0.0 0.32 11.0 0.0 5.5 5 0 0 5 5 5 0 CH-like domain in sperm protein AAA PF00004.27 024726.4_26227001_2 - 9.4e-14 51.8 0.0 2.2e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IQ PF00612.25 024726.4_26227001_2 - 0.0047 16.5 4.9 0.0054 16.3 0.6 3.1 3 0 0 3 3 3 1 IQ calmodulin-binding motif DUF258 PF03193.14 024726.4_26227001_2 - 0.085 12.6 0.1 0.2 11.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 DUF1764 PF08576.8 024726.4_26227001_2 - 0.39 11.5 27.8 0.94 10.2 12.3 3.1 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Presenilin PF01080.15 024726.4_26227001_2 - 1.1 7.8 8.8 1.8 7.1 8.8 1.2 1 0 0 1 1 1 0 Presenilin LRR_4 PF12799.5 001100645.2_45728001_2 - 9.3e-12 44.8 23.3 2.2e-06 27.7 4.1 5.8 3 1 2 6 6 6 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001100645.2_45728001_2 - 4e-09 36.0 20.8 0.00034 20.2 3.2 4.3 3 0 0 3 3 3 3 Leucine rich repeat LRR_6 PF13516.4 001100645.2_45728001_2 - 0.16 12.0 18.1 0.81 9.8 0.2 5.2 3 1 1 4 4 4 0 Leucine Rich repeat Pkinase_Tyr PF07714.15 001257347.1_45729001_1 - 3.9e-133 442.5 0.0 8.7e-82 274.2 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.23 001257347.1_45729001_1 - 2.3e-70 236.8 0.0 3.3e-48 164.2 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Kdo PF06293.12 001257347.1_45729001_1 - 0.011 14.9 0.0 0.084 12.1 0.1 2.0 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 001257347.1_45729001_1 - 0.023 13.9 0.0 0.47 9.6 0.0 2.6 2 1 0 2 2 2 0 Kinase-like RIO1 PF01163.20 001257347.1_45729001_1 - 0.039 13.4 0.0 1.6 8.1 0.0 2.2 2 0 0 2 2 2 0 RIO1 family APH PF01636.21 001257347.1_45729001_1 - 0.2 11.4 1.7 0.4 10.4 0.2 2.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family TIR PF01582.18 001279600.1_24222001_1 - 4.4e-14 52.5 0.2 2e-13 50.4 0.2 2.0 1 1 0 1 1 1 1 TIR domain Death PF00531.20 001279600.1_24222001_1 - 4.7e-14 52.2 0.8 1.1e-13 51.0 0.1 2.0 3 0 0 3 3 3 1 Death domain TIR_2 PF13676.4 001279600.1_24222001_1 - 2.9e-12 46.7 0.0 5.7e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 TIR domain CHCH PF06747.11 001279540.1_24222001_1 - 5.2e-10 39.1 2.8 5.2e-10 39.1 2.8 2.4 2 1 0 2 2 2 1 CHCH domain CX9C PF16860.3 001279540.1_24222001_1 - 0.00074 19.3 10.7 0.0011 18.8 2.5 2.6 2 1 0 2 2 2 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.8 001279540.1_24222001_1 - 0.015 15.2 1.2 0.015 15.2 1.2 2.5 1 1 2 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like Cdd1 PF11731.6 001279540.1_24222001_1 - 0.029 14.5 2.2 4 7.6 0.2 2.3 1 1 1 2 2 2 0 Pathogenicity locus UCR_hinge PF02320.14 001279540.1_24222001_1 - 6.1 7.0 11.9 9.4 6.4 4.7 3.0 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein DUF3716 PF12511.6 001279540.1_24222001_1 - 7.1 6.6 7.6 4.1 7.4 0.6 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF3716) COX6B PF02297.15 001279540.1_24222001_1 - 8.7 6.5 12.3 0.33 11.1 4.0 2.1 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb Pet191_N PF10203.7 001279540.1_24222001_1 - 9.2 6.5 10.6 22 5.3 0.4 3.0 1 1 2 3 3 3 0 Cytochrome c oxidase assembly protein PET191 Ald_Xan_dh_C2 PF02738.16 001278764.1_09929001_1 - 2.5e-189 630.1 0.0 3.3e-189 629.7 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 001278764.1_09929001_1 - 2.6e-42 144.3 0.1 5.7e-42 143.2 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.20 001278764.1_09929001_1 - 1.7e-30 105.5 0.1 3e-30 104.7 0.1 1.4 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.18 001278764.1_09929001_1 - 5.7e-29 99.8 0.1 1.5e-28 98.4 0.1 1.8 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.15 001278764.1_09929001_1 - 1.4e-28 99.0 0.0 3.6e-26 91.2 0.0 2.6 2 0 0 2 2 2 2 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.25 001278764.1_09929001_1 - 8e-09 35.2 0.2 3.9e-08 33.0 0.2 2.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain LIM PF00412.20 001281678.1_31323001_2 - 1.3e-30 105.2 26.3 7.2e-16 58.0 7.9 2.5 2 0 0 2 2 2 2 LIM domain Homeobox PF00046.27 001281678.1_31323001_2 - 6.5e-18 64.2 2.3 1.6e-17 62.9 2.3 1.7 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001281678.1_31323001_2 - 0.00012 21.8 0.0 0.00029 20.5 0.0 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.6 152849.2_45724001_2 - 8e-31 105.2 5.1 1e-27 95.2 0.8 3.5 3 0 0 3 3 3 2 Homeodomain leucine-zipper encoding, Homez Homeobox PF00046.27 152849.2_45724001_2 - 1.4e-13 50.3 2.2 0.0021 17.7 1.0 3.4 3 0 0 3 3 3 3 Homeobox domain Homeobox_KN PF05920.9 152849.2_45724001_2 - 3.1e-07 30.0 0.1 0.0015 18.3 0.0 3.5 3 0 0 3 3 3 1 Homeobox KN domain RNA_pol_3_Rpc31 PF11705.6 152849.2_45724001_2 - 0.02 15.0 2.8 0.041 14.0 2.8 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 4HBT_3 PF13622.4 152849.2_45724001_2 - 0.56 10.3 3.3 13 5.9 0.5 2.7 2 0 0 2 2 2 0 Thioesterase-like superfamily SH3_2 PF07653.15 022693.4_45729001_2 - 4.4e-22 77.4 0.1 9.5e-11 41.1 0.2 3.4 4 0 0 4 4 4 2 Variant SH3 domain SH3_9 PF14604.4 022693.4_45729001_2 - 1e-10 41.2 0.7 1.9e-09 37.1 0.0 2.3 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.26 022693.4_45729001_2 - 1.2e-09 37.5 0.7 3.4e-09 36.0 0.0 2.1 2 1 0 2 2 2 1 SH3 domain ZU5 PF00791.18 022693.4_45729001_2 - 6.1e-09 36.0 0.1 1.3e-08 35.0 0.1 1.5 1 0 0 1 1 1 1 ZU5 domain Crystall PF00030.17 001281377.1_31322001_1 - 6.3e-60 199.2 0.3 2e-30 104.7 0.0 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 001281377.1_31322001_1 - 7.7e-07 28.8 0.0 0.0063 16.3 0.0 2.3 2 0 0 2 2 2 2 Peptidase inhibitor family I36 Crystall_3 PF08964.8 001281377.1_31322001_1 - 1.3e-05 25.2 0.2 0.092 12.8 0.1 3.2 3 0 0 3 3 3 2 Beta/Gamma crystallin Cor1 PF04803.10 001281597.1_31323001_1 - 7.1e-56 187.9 30.4 1.5e-55 186.9 30.4 1.5 1 0 0 1 1 1 1 Cor1/Xlr/Xmr conserved region Focal_AT PF03623.11 001281597.1_31323001_1 - 0.015 15.1 0.5 0.015 15.1 0.5 2.2 1 1 1 2 2 2 0 Focal adhesion targeting region Nucleoporin_FG2 PF15967.3 001281597.1_31323001_1 - 4.6 5.5 7.1 6.1 5.1 7.1 1.2 1 0 0 1 1 1 0 Nucleoporin FG repeated region Cyclin_N PF00134.21 001281634.1_31326001_1 - 5.1e-48 161.9 0.2 8.2e-48 161.3 0.2 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_N2 PF16500.3 001281634.1_31326001_1 - 8.9e-42 143.0 1.7 1.4e-41 142.4 1.7 1.3 1 0 0 1 1 1 1 N-terminal region of cyclin_N Cyclin_C PF02984.17 001281634.1_31326001_1 - 4.1e-27 94.5 0.3 9.7e-27 93.3 0.2 1.7 2 0 0 2 2 2 1 Cyclin, C-terminal domain Prefoldin_2 PF01920.18 001265595.1_26222001_1 - 4.3e-26 90.8 10.2 5.6e-26 90.5 10.2 1.1 1 0 0 1 1 1 1 Prefoldin subunit IncA PF04156.12 001265595.1_26222001_1 - 1e-05 25.3 9.6 1.2e-05 25.1 9.6 1.1 1 0 0 1 1 1 1 IncA protein Prefoldin PF02996.15 001265595.1_26222001_1 - 0.00042 20.1 7.1 0.00068 19.4 7.1 1.3 1 0 0 1 1 1 1 Prefoldin subunit YgaB PF14182.4 001265595.1_26222001_1 - 0.011 16.1 10.8 0.27 11.6 1.5 2.5 2 1 0 2 2 2 0 YgaB-like protein ALIX_LYPXL_bnd PF13949.4 001265595.1_26222001_1 - 0.018 14.2 6.9 0.48 9.5 1.2 2.0 2 0 0 2 2 2 0 ALIX V-shaped domain binding to HIV ADIP PF11559.6 001265595.1_26222001_1 - 0.029 14.3 1.0 0.029 14.3 1.0 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Occludin_ELL PF07303.11 001265595.1_26222001_1 - 0.037 14.6 5.9 0.32 11.6 0.7 2.1 2 0 0 2 2 2 0 Occludin homology domain BRE1 PF08647.9 001265595.1_26222001_1 - 0.084 12.8 9.9 0.2 11.6 1.5 2.2 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase OmpH PF03938.12 001265595.1_26222001_1 - 0.091 12.6 17.8 0.31 10.9 6.8 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Prefoldin_3 PF13758.4 001265595.1_26222001_1 - 0.12 12.3 3.4 0.21 11.5 2.2 2.0 1 1 0 1 1 1 0 Prefoldin subunit Spc24 PF08286.9 001265595.1_26222001_1 - 0.19 11.8 4.4 0.61 10.2 0.3 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 YscO PF07321.10 001265595.1_26222001_1 - 0.28 11.0 13.3 0.041 13.7 4.0 2.1 2 0 0 2 2 2 0 Type III secretion protein YscO GAS PF13851.4 001265595.1_26222001_1 - 0.3 10.3 12.8 0.11 11.7 3.0 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF3450 PF11932.6 001265595.1_26222001_1 - 0.31 10.1 12.3 0.047 12.8 4.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) THOC7 PF05615.11 001265595.1_26222001_1 - 0.33 11.1 14.6 0.095 12.8 5.3 2.3 2 0 0 2 2 2 0 Tho complex subunit 7 DUF1664 PF07889.10 001265595.1_26222001_1 - 0.4 10.6 4.3 0.3 11.0 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF641 PF04859.10 001265595.1_26222001_1 - 0.48 10.6 6.9 0.19 11.9 0.8 2.1 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) FlaC_arch PF05377.9 001265595.1_26222001_1 - 0.51 10.6 0.2 0.51 10.6 0.2 2.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) FliJ PF02050.14 001265595.1_26222001_1 - 0.6 10.2 16.6 0.053 13.6 7.4 2.2 2 0 0 2 2 2 0 Flagellar FliJ protein APG6 PF04111.10 001265595.1_26222001_1 - 0.82 8.9 11.9 3.6 6.8 11.9 1.8 1 1 0 1 1 1 0 Autophagy protein Apg6 Taxilin PF09728.7 001265595.1_26222001_1 - 1.1 8.3 14.1 0.88 8.6 4.6 2.1 2 0 0 2 2 2 0 Myosin-like coiled-coil protein Fib_alpha PF08702.8 001265595.1_26222001_1 - 1.3 9.1 6.6 0.71 9.9 1.2 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4407 PF14362.4 001265595.1_26222001_1 - 1.6 7.9 8.5 2.7 7.1 8.5 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TBPIP PF07106.11 001265595.1_26222001_1 - 1.6 8.3 9.0 0.74 9.4 0.9 2.1 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) HIP1_clath_bdg PF16515.3 001265595.1_26222001_1 - 1.7 9.2 12.7 4.1 7.9 2.2 2.2 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DMPK_coil PF08826.8 001265595.1_26222001_1 - 1.9 8.5 17.0 0.73 9.9 4.7 2.2 2 0 0 2 2 2 0 DMPK coiled coil domain like EzrA PF06160.10 001265595.1_26222001_1 - 2 6.4 10.3 0.14 10.2 2.7 1.9 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA DUF106 PF01956.14 001265595.1_26222001_1 - 2 8.0 4.7 2.1 7.9 0.2 2.0 2 0 0 2 2 2 0 Integral membrane protein DUF106 Phage_GP20 PF06810.9 001265595.1_26222001_1 - 3.9 7.1 10.7 0.75 9.4 1.7 2.1 1 1 1 2 2 2 0 Phage minor structural protein GP20 DUF4404 PF14357.4 001265595.1_26222001_1 - 4.5 7.9 8.9 0.98 10.0 1.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) IFT57 PF10498.7 001265595.1_26222001_1 - 4.6 6.0 9.9 5.9 5.6 2.7 2.0 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Spc7 PF08317.9 001265595.1_26222001_1 - 6 5.5 13.1 11 4.7 13.1 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF724 PF05266.12 001265595.1_26222001_1 - 6.4 6.4 9.4 28 4.3 9.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF724) BRE PF06113.10 001281577.1_31323001_1 - 6.4e-143 475.2 0.0 7.4e-143 475.0 0.0 1.0 1 0 0 1 1 1 1 Brain and reproductive organ-expressed protein (BRE) UQ_con PF00179.24 001281577.1_31323001_1 - 0.069 12.7 2.9 3.3 7.2 0.1 2.7 3 0 0 3 3 3 0 Ubiquitin-conjugating enzyme Glyco_hydro_18 PF00704.26 001079689.2_45725001_2 - 6.8e-96 321.5 0.0 8.1e-96 321.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_14 PF01607.22 001079689.2_45725001_2 - 1.9e-08 34.2 4.5 3.7e-08 33.3 4.5 1.5 1 0 0 1 1 1 1 Chitin binding Peritrophin-A domain 7tm_1 PF00001.19 012719.2_45728001_1 - 1.7e-62 210.9 22.7 3.2e-62 210.1 22.7 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 012719.2_45728001_1 - 3.7e-11 42.7 18.5 6.8e-11 41.9 18.5 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 012719.2_45728001_1 - 4.2e-05 22.9 14.1 4.2e-05 22.9 14.1 2.1 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 012719.2_45728001_1 - 0.00048 19.8 19.4 0.0007 19.3 19.4 1.2 1 0 0 1 1 1 1 Olfactory receptor T2SSM PF04612.10 012719.2_45728001_1 - 0.17 11.8 0.2 0.32 10.9 0.2 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M NdhL PF10716.7 012719.2_45728001_1 - 2.4 8.0 11.3 0.5 10.2 6.6 2.3 2 0 0 2 2 2 0 NADH dehydrogenase transmembrane subunit eRF1_2 PF03464.13 001281670.1_31325001_2 - 3.8e-46 156.6 0.1 6.7e-46 155.8 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.13 001281670.1_31325001_2 - 1.4e-38 131.7 0.3 2.6e-38 130.8 0.3 1.5 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.13 001281670.1_31325001_2 - 1.8e-19 69.9 0.0 3e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 Ribosomal_L7Ae PF01248.24 001281670.1_31325001_2 - 0.021 14.4 0.0 0.045 13.4 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family SET PF00856.26 001271175.1_45729001_1 - 1e-39 136.5 4.1 4.2e-39 134.5 0.7 2.8 2 1 0 2 2 2 1 SET domain Pre-SET PF05033.14 001271175.1_45729001_1 - 1e-15 58.2 9.9 2.6e-15 56.9 9.9 1.8 1 0 0 1 1 1 1 Pre-SET motif MBD PF01429.17 001271175.1_45729001_1 - 2.3e-12 46.3 0.0 4.7e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 Methyl-CpG binding domain DUF4537 PF15057.4 001271175.1_45729001_1 - 0.0049 16.7 0.0 0.013 15.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) Agenet PF05641.10 001271175.1_45729001_1 - 0.36 11.2 2.0 13 6.2 0.0 3.3 3 0 0 3 3 3 0 Agenet domain Cyclin_N PF00134.21 001281383.1_31323001_1 - 1.4e-43 147.6 0.3 3.2e-43 146.4 0.3 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 001281383.1_31323001_1 - 1.3e-33 115.5 0.4 3e-33 114.3 0.4 1.7 1 0 0 1 1 1 1 Cyclin, C-terminal domain Forkhead PF00250.16 134339.1_45722001_1 - 2.8e-35 120.3 0.0 3.7e-35 120.0 0.0 1.1 1 0 0 1 1 1 1 Forkhead domain ICAM_N PF03921.12 001279659.1_24222001_1 - 2.1e-40 136.2 1.3 4.1e-40 135.2 1.3 1.5 1 0 0 1 1 1 1 Intercellular adhesion molecule (ICAM), N-terminal domain Ig_2 PF13895.4 001279659.1_24222001_1 - 0.026 14.7 0.3 0.13 12.5 0.0 2.1 2 1 0 2 2 2 0 Immunoglobulin domain ig PF00047.23 001279659.1_24222001_1 - 0.045 13.8 1.0 0.096 12.7 0.0 2.0 3 0 0 3 3 3 0 Immunoglobulin domain Ig_3 PF13927.4 001279659.1_24222001_1 - 0.054 14.0 0.2 0.33 11.4 0.0 2.3 3 0 0 3 3 3 0 Immunoglobulin domain LIM PF00412.20 001281609.1_31323001_3 - 2.4e-32 110.8 24.7 9.2e-18 64.1 1.9 2.2 2 0 0 2 2 2 2 LIM domain Homeobox PF00046.27 001281609.1_31323001_3 - 7.8e-20 70.3 1.9 1.4e-19 69.5 1.9 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001281609.1_31323001_3 - 1.8e-05 24.4 0.1 4.9e-05 23.0 0.1 1.7 1 0 0 1 1 1 1 Homeobox KN domain Ndr PF03096.12 001271092.1_45726001_1 - 7.2e-123 408.7 0.0 8.9e-123 408.4 0.0 1.1 1 0 0 1 1 1 1 Ndr family FBA PF04300.11 148169.2_26225001_1 - 2.1e-65 219.8 0.1 3.6e-65 219.0 0.1 1.3 1 0 0 1 1 1 1 F-box associated region F-box-like PF12937.5 148169.2_26225001_1 - 5.9e-10 38.7 1.7 1.4e-09 37.6 1.7 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 148169.2_26225001_1 - 3.2e-09 36.3 1.0 8e-09 35.0 1.0 1.6 1 0 0 1 1 1 1 F-box domain DUF2464 PF10240.7 001271232.1_45723001_2 - 3.9e-83 278.6 0.0 5e-83 278.3 0.0 1.1 1 0 0 1 1 1 1 Multivesicular body subunit 12 PRIMA1 PF16101.3 001271232.1_45723001_2 - 1 9.2 6.5 3.5 7.6 6.5 1.9 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 RAM PF15320.4 025997.2_32923001_3 - 2.2e-23 82.5 11.5 3.7e-23 81.8 11.5 1.4 1 0 0 1 1 1 1 mRNA cap methylation, RNMT-activating mini protein L51_S25_CI-B8 PF05047.14 001279587.1_24221001_1 - 4.2e-14 52.0 0.0 5.3e-14 51.7 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain zf-H2C2_2 PF13465.4 001281620.1_31329001_3 - 2.8e-29 100.1 56.6 1e-07 32.0 5.1 7.7 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.24 001281620.1_31329001_3 - 9.4e-24 82.4 66.2 0.00016 21.8 5.0 7.9 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001281620.1_31329001_3 - 4.7e-11 42.4 70.9 0.044 14.5 4.4 8.5 8 0 0 8 8 7 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001281620.1_31329001_3 - 5.6e-08 32.8 47.4 0.016 15.4 1.7 7.6 7 0 0 7 7 7 5 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 001281620.1_31329001_3 - 9.1e-08 32.1 25.9 2.4e-07 30.8 1.4 4.0 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.5 001281620.1_31329001_3 - 5.7e-06 26.4 52.7 0.034 14.4 2.4 7.3 7 0 0 7 7 7 5 Zinc-finger of C2H2 type Homeobox PF00046.27 001281620.1_31329001_3 - 8e-05 22.3 0.0 0.00021 20.9 0.0 1.7 1 0 0 1 1 1 1 Homeobox domain zf-C2H2_6 PF13912.4 001281620.1_31329001_3 - 0.001 18.9 58.8 0.77 9.7 0.8 7.7 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2HE PF16278.3 001281620.1_31329001_3 - 0.14 12.5 0.1 0.14 12.5 0.1 6.6 4 2 3 7 7 5 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_2 PF12756.5 001281620.1_31329001_3 - 1.2 9.4 41.6 0.052 13.7 1.2 6.2 2 2 3 5 5 5 0 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.3 001281620.1_31329001_3 - 3.3 7.4 27.6 0.14 11.8 0.5 5.6 5 0 0 5 5 5 0 zinc-finger C2H2-type zf-C2H2_9 PF16293.3 001281620.1_31329001_3 - 8.5 6.2 16.3 10 5.9 0.0 5.0 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) NDUF_B6 PF09782.7 001279763.1_24221001_1 - 1.9e-51 174.2 1.8 2.1e-51 174.0 1.8 1.0 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit Sensor PF13796.4 001279763.1_24221001_1 - 0.13 12.2 0.1 0.16 11.9 0.1 1.1 1 0 0 1 1 1 0 Putative sensor PspB PF06667.10 001279763.1_24221001_1 - 1.3 9.0 4.2 0.66 9.9 1.3 1.9 2 0 0 2 2 2 0 Phage shock protein B zf-C2H2_7 PF15269.4 001279763.1_24221001_3 - 0.044 13.7 0.4 0.066 13.2 0.4 1.1 1 0 0 1 1 1 0 Zinc-finger Sarcoglycan_2 PF05510.11 001281663.1_31323001_1 - 5.6e-59 199.7 0.0 1.4e-58 198.3 0.0 1.5 1 1 0 1 1 1 1 Sarcoglycan alpha/epsilon DUF4801 PF16059.3 001281663.1_31323001_3 - 0.21 11.5 2.0 0.4 10.6 2.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4801) Dpy-30 PF05186.11 001108055.3_45726001_3 - 5e-21 74.0 0.2 2.4e-20 71.8 0.2 2.0 2 0 0 2 2 2 1 Dpy-30 motif ADK PF00406.20 001108055.3_45726001_3 - 2.9e-11 43.5 0.3 2.4e-07 30.8 0.4 3.1 2 1 0 2 2 2 2 Adenylate kinase AAA_18 PF13238.4 001108055.3_45726001_3 - 0.00015 22.2 0.2 0.00015 22.2 0.2 2.6 2 2 0 2 2 2 1 AAA domain AAA_17 PF13207.4 001108055.3_45726001_3 - 0.00051 20.4 13.2 0.0017 18.7 0.3 3.7 3 1 1 4 4 4 2 AAA domain Hydin_ADK PF17213.1 001108055.3_45726001_3 - 0.0021 18.2 0.3 0.0021 18.2 0.3 2.7 3 1 0 3 3 3 1 Hydin Adenylate kinase-like domain 6PF2K PF01591.16 001108055.3_45726001_3 - 0.03 13.5 0.0 0.074 12.2 0.0 1.6 1 0 0 1 1 1 0 6-phosphofructo-2-kinase GBP_C PF02841.12 001108055.3_45726001_3 - 0.067 12.4 18.8 0.29 10.4 7.7 2.4 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain RIIa PF02197.15 001108055.3_45726001_3 - 0.092 12.3 0.0 0.27 10.8 0.0 1.8 1 0 0 1 1 1 0 Regulatory subunit of type II PKA R-subunit MMR_HSR1 PF01926.21 001108055.3_45726001_3 - 0.13 12.2 0.0 2.2 8.3 0.0 2.9 3 0 0 3 3 3 0 50S ribosome-binding GTPase AAA_16 PF13191.4 001108055.3_45726001_3 - 0.23 11.7 2.0 0.62 10.3 0.1 2.6 1 1 1 2 2 2 0 AAA ATPase domain Mlh1_C PF16413.3 001108055.3_45726001_3 - 0.28 10.4 6.8 0.33 10.1 0.2 3.1 3 0 0 3 3 3 0 DNA mismatch repair protein Mlh1 C-terminus DUF2379 PF09543.8 001108055.3_45726001_3 - 0.72 9.9 5.6 0.93 9.6 3.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2379) MCU PF04678.11 001108055.3_45726001_3 - 1.6 8.7 5.5 14 5.6 0.1 3.0 3 1 0 3 3 3 0 Mitochondrial calcium uniporter Ras PF00071.20 001256278.1_26223001_2 - 2.4e-44 150.7 0.1 3e-44 150.3 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001256278.1_26223001_2 - 2.7e-29 101.7 0.0 4.2e-29 101.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001256278.1_26223001_2 - 6e-14 51.7 0.0 8.4e-14 51.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001256278.1_26223001_2 - 1.7e-06 27.9 0.0 3e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001256278.1_26223001_2 - 0.0069 15.6 0.0 0.0088 15.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.8 001256278.1_26223001_2 - 0.023 14.0 0.0 0.035 13.4 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Dynamin_N PF00350.21 001256278.1_26223001_2 - 0.057 13.3 0.0 2.3 8.1 0.0 2.9 3 1 0 3 3 3 0 Dynamin family TniB PF05621.9 001256278.1_26223001_2 - 0.09 11.8 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein ALMS_motif PF15309.4 001163214.2_45726001_1 - 3.2e-50 169.9 19.7 7.3e-50 168.7 19.7 1.6 1 0 0 1 1 1 1 ALMS motif Ank_2 PF12796.5 001271264.1_45729001_2 - 1.9e-56 188.5 16.9 1.4e-17 63.9 0.5 6.1 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.28 001271264.1_45729001_2 - 8.5e-49 161.8 23.0 3.7e-06 27.0 0.0 8.8 8 0 0 8 8 8 8 Ankyrin repeat Ank_4 PF13637.4 001271264.1_45729001_2 - 6.1e-45 150.9 19.4 6e-10 39.3 0.6 9.3 3 3 6 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.4 001271264.1_45729001_2 - 1.3e-42 138.8 9.4 6.9e-05 22.8 0.2 9.8 9 0 0 9 9 9 9 Ankyrin repeat Ank_5 PF13857.4 001271264.1_45729001_2 - 1.1e-40 136.9 16.8 3.9e-08 33.3 1.5 9.2 3 2 6 9 9 9 8 Ankyrin repeats (many copies) VPS9 PF02204.16 001271264.1_45729001_2 - 1.7e-22 79.5 0.1 3.5e-22 78.5 0.1 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ribonuc_red_sm PF00268.19 001271264.1_45729001_2 - 0.06 12.7 0.5 0.098 12.0 0.5 1.2 1 0 0 1 1 1 0 Ribonucleotide reductase, small chain PEGA PF08308.9 001271264.1_45729001_2 - 0.13 12.0 0.0 1.5 8.6 0.0 2.7 3 0 0 3 3 3 0 PEGA domain p450 PF00067.20 001281683.1_31324001_1 - 4.1e-157 523.5 0.1 4.7e-157 523.3 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 KOW PF00467.27 001107497.2_45728001_3 - 2.1e-29 100.4 14.5 1.5e-07 31.0 0.2 7.3 8 0 0 8 8 8 6 KOW motif Spt5-NGN PF03439.11 001107497.2_45728001_3 - 3.9e-28 97.0 0.1 7.1e-28 96.2 0.1 1.5 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.6 001107497.2_45728001_3 - 5e-14 53.0 6.6 5e-14 53.0 6.6 3.2 2 1 0 2 2 2 1 Spt5 transcription elongation factor, acidic N-terminal DUF3912 PF13051.4 001107497.2_45728001_3 - 0.025 14.6 0.6 3.1 7.8 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3912) Ribonuc_P_40 PF08584.9 001107497.2_45728001_3 - 0.054 12.6 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Ribonuclease P 40kDa (Rpp40) subunit CDC45 PF02724.12 001107497.2_45728001_3 - 1.5 6.9 22.3 2.2 6.4 22.3 1.1 1 0 0 1 1 1 0 CDC45-like protein NCKAP5 PF15246.4 001271369.1_45729001_1 - 4.1e-84 282.7 0.3 1.8e-83 280.6 0.0 1.9 2 0 0 2 2 2 1 Nck-associated protein 5, Peripheral clock protein GCN5L1 PF06320.11 001271369.1_45729001_1 - 0.13 12.3 3.8 0.26 11.3 3.8 1.4 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) TSC22 PF01166.16 001271369.1_45729001_1 - 3.2 8.0 7.2 16 5.8 0.5 2.4 2 0 0 2 2 2 0 TSC-22/dip/bun family Ribonucleas_3_3 PF14622.4 001107655.2_45729001_3 - 7.2e-44 148.9 0.5 1.7e-23 83.1 0.0 3.1 3 0 0 3 3 3 2 Ribonuclease-III-like Ribonuclease_3 PF00636.24 001107655.2_45729001_3 - 8.7e-43 145.1 0.4 9e-21 74.3 0.1 3.0 2 0 0 2 2 2 2 Ribonuclease III domain dsrm PF00035.24 001107655.2_45729001_3 - 8.3e-15 55.1 0.0 2.3e-14 53.7 0.0 1.9 1 0 0 1 1 1 1 Double-stranded RNA binding motif MIP-T3 PF10243.7 001107655.2_45729001_3 - 0.28 9.7 27.4 0.6 8.6 27.4 1.5 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 LRR_8 PF13855.4 001279764.1_24225001_1 - 7.1e-35 118.5 46.6 1e-13 50.7 7.4 7.9 5 2 2 7 7 7 7 Leucine rich repeat TIR PF01582.18 001279764.1_24225001_1 - 8.5e-22 77.7 1.8 1e-21 77.4 0.6 1.8 2 0 0 2 2 2 1 TIR domain LRR_4 PF12799.5 001279764.1_24225001_1 - 2.8e-19 68.7 49.2 0.00086 19.5 4.6 9.3 7 1 2 10 10 10 6 Leucine Rich repeats (2 copies) TIR_2 PF13676.4 001279764.1_24225001_1 - 1.1e-09 38.4 0.1 2.9e-09 37.1 0.0 1.8 2 0 0 2 2 2 1 TIR domain LRR_9 PF14580.4 001279764.1_24225001_1 - 1.3e-08 34.4 15.6 7.4e-05 22.2 0.4 4.7 2 2 2 4 4 4 2 Leucine-rich repeat LRR_5 PF13306.4 001279764.1_24225001_1 - 4.2e-07 29.8 1.3 4.2e-07 29.8 1.3 4.2 3 1 1 4 4 4 2 Leucine rich repeats (6 copies) LRRCT PF01463.22 001279764.1_24225001_1 - 0.00019 21.6 0.2 0.00073 19.8 0.2 2.1 2 0 0 2 2 2 1 Leucine rich repeat C-terminal domain LRR_1 PF00560.31 001279764.1_24225001_1 - 0.00073 19.5 38.3 0.11 12.9 0.6 10.7 11 1 0 11 11 11 3 Leucine Rich Repeat DUF1863 PF08937.9 001279764.1_24225001_1 - 0.18 12.0 0.4 0.76 10.0 0.4 2.0 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) Aph-1 PF06105.10 146104.3_32927001_2 - 3.9e-92 307.7 14.0 5.6e-92 307.2 14.0 1.2 1 0 0 1 1 1 1 Aph-1 protein Peptidase_M3_N PF08439.8 146104.3_32927001_2 - 0.092 12.9 0.0 0.25 11.5 0.0 1.7 2 0 0 2 2 2 0 Oligopeptidase F Ets PF00178.20 001108059.3_45726001_2 - 3.9e-36 123.3 0.7 5.9e-36 122.7 0.7 1.3 1 0 0 1 1 1 1 Ets-domain SH3_1 PF00018.26 001282964.1_26227001_3 - 4.1e-05 23.0 0.0 7.9e-05 22.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH2 PF00017.22 001282964.1_26227001_3 - 0.0002 21.2 0.0 0.0004 20.3 0.0 1.4 1 0 0 1 1 1 1 SH2 domain SH3_9 PF14604.4 001282964.1_26227001_3 - 0.0002 21.0 0.4 0.0035 17.0 0.0 2.5 2 0 0 2 2 2 1 Variant SH3 domain p450 PF00067.20 001281329.1_31325001_2 - 2.3e-144 481.5 0.1 2.7e-144 481.2 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 TPP_enzyme_M PF00205.20 001281329.1_31325001_2 - 0.13 11.9 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain Ferlin_C PF16165.3 001276720.1_45729001_1 - 2.1e-08 34.2 2.8 3.1e-08 33.6 2.8 1.2 1 0 0 1 1 1 1 Ferlin C-terminus C2 PF00168.28 001276720.1_45729001_2 - 3.8e-78 258.3 6.4 3.2e-17 62.5 0.0 9.0 8 1 0 8 8 8 7 C2 domain Ferlin_C PF16165.3 001276720.1_45729001_2 - 7.7e-34 116.7 1.7 2.5e-30 105.3 0.1 4.0 2 2 2 4 4 4 2 Ferlin C-terminus FerB PF08150.10 001276720.1_45729001_2 - 2.7e-31 107.9 0.2 9.4e-31 106.1 0.0 2.1 2 0 0 2 2 2 1 FerB (NUC096) domain FerI PF08151.10 001276720.1_45729001_2 - 3.6e-20 71.7 1.1 3.6e-20 71.7 1.1 2.0 2 0 0 2 2 2 1 FerI (NUC094) domain Lys PF00062.18 001279662.1_24221001_1 - 4.8e-57 191.4 2.3 5.4e-57 191.3 2.3 1.0 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family SLT PF01464.18 001279662.1_24221001_1 - 0.00065 19.2 0.0 0.00092 18.7 0.0 1.2 1 0 0 1 1 1 1 Transglycosylase SLT domain Destabilase PF05497.10 001279662.1_24221001_1 - 0.087 13.0 2.7 0.14 12.3 1.9 1.8 1 1 1 2 2 2 0 Destabilase Lys PF00062.18 001280710.1_39521001_1 - 3.6e-56 188.6 5.5 4e-56 188.5 5.5 1.0 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family SLT PF01464.18 001280710.1_39521001_1 - 0.0047 16.4 0.0 0.0068 15.9 0.0 1.2 1 0 0 1 1 1 1 Transglycosylase SLT domain Transglycosylas PF06737.12 001280710.1_39521001_1 - 1.4 9.5 5.2 6.4 7.4 5.2 1.9 1 1 0 1 1 1 0 Transglycosylase-like domain Mem_trans PF03547.16 001267050.1_26229001_3 - 3.7e-18 65.0 18.4 4.5e-12 44.9 5.5 2.4 1 1 1 2 2 2 2 Membrane transport protein DEP PF00610.19 001267050.1_26229001_3 - 1.8e-13 50.2 0.0 4.9e-13 48.8 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Tmemb_9 PF05434.9 001277263.1_45724001_3 - 4.5e-54 182.1 0.1 6.8e-54 181.6 0.1 1.3 1 0 0 1 1 1 1 TMEM9 RRM PF10378.7 001277263.1_45724001_3 - 0.63 9.7 3.1 12 5.6 0.1 2.5 2 0 0 2 2 2 0 Putative RRM domain Peptidase_C12 PF01088.19 001270952.1_26223001_3 - 3.6e-62 209.7 0.1 4.5e-62 209.4 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 COE1_DBD PF16422.3 053820.2_45726001_1 - 1.2e-146 486.0 1.2 1.7e-146 485.6 1.2 1.2 1 0 0 1 1 1 1 Transcription factor COE1 DNA-binding domain COE1_HLH PF16423.3 053820.2_45726001_1 - 3.5e-36 122.5 3.0 1e-29 101.8 0.4 2.5 2 0 0 2 2 2 2 Transcription factor COE1 helix-loop-helix domain TIG PF01833.22 053820.2_45726001_1 - 3.2e-12 46.2 0.3 9.9e-12 44.6 0.3 1.9 1 0 0 1 1 1 1 IPT/TIG domain Kelch_5 PF13854.4 001281357.1_31329001_1 - 5e-34 115.6 0.7 0.0002 21.1 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.4 001281357.1_31329001_1 - 5.5e-29 99.7 8.1 6e-06 26.3 0.0 7.8 8 0 0 8 8 8 5 Galactose oxidase, central domain Kelch_4 PF13418.4 001281357.1_31329001_1 - 4.9e-25 87.1 3.9 4.2e-05 23.3 0.0 6.8 4 2 2 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.23 001281357.1_31329001_1 - 5.1e-25 86.7 4.6 1.4e-05 24.5 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 001281357.1_31329001_1 - 1.1e-22 79.3 0.9 0.0055 16.8 0.0 6.8 5 1 1 6 6 6 5 Kelch motif Kelch_2 PF07646.13 001281357.1_31329001_1 - 4.3e-18 64.4 2.8 0.0017 18.2 0.0 6.6 6 0 0 6 6 6 4 Kelch motif fn3 PF00041.19 001281357.1_31329001_1 - 1.8e-09 37.7 1.4 0.072 13.3 0.0 4.9 6 0 0 6 6 6 3 Fibronectin type III domain DUF2452 PF10504.7 024097.3_26223001_2 - 3.1e-73 244.2 0.0 5e-73 243.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2452) NDUF_B5 PF09781.7 001283601.1_29523001_2 - 3.4e-88 294.0 0.0 4.1e-88 293.7 0.0 1.1 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit DUF3749 PF12568.6 001283601.1_29523001_2 - 0.084 12.5 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Rhodanese PF00581.18 003312.5_26223001_1 - 2.7e-27 95.3 0.0 1.6e-12 47.7 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain ESSS PF10183.7 001279697.1_24221001_1 - 2.3e-49 165.8 0.0 2.7e-49 165.6 0.0 1.1 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Homeobox_KN PF05920.9 001279718.1_24222001_2 - 1.1e-17 63.5 0.6 2e-17 62.7 0.6 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 001279718.1_24222001_2 - 1.2e-06 28.1 0.4 2.8e-06 26.9 0.4 1.6 1 0 0 1 1 1 1 Homeobox domain AICARFT_IMPCHas PF01808.16 001279718.1_24222001_2 - 0.16 11.3 0.0 0.23 10.7 0.0 1.1 1 0 0 1 1 1 0 AICARFT/IMPCHase bienzyme PKI PF02827.14 012627.3_45723001_2 - 9.8e-25 86.4 0.3 1.4e-24 86.0 0.3 1.2 1 0 0 1 1 1 1 cAMP-dependent protein kinase inhibitor Ndufs5 PF10200.7 001279556.1_24221001_1 - 4.2e-58 193.5 0.6 4.8e-58 193.3 0.6 1.0 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa Cmc1 PF08583.8 001279556.1_24221001_1 - 0.00016 21.5 1.4 0.00021 21.1 1.4 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like 7tm_2 PF00002.22 133511.2_45729001_2 - 4.2e-93 311.0 17.7 6.3e-93 310.5 17.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 133511.2_45729001_2 - 5.3e-26 90.6 1.7 5.3e-26 90.6 1.7 2.4 2 0 0 2 2 2 1 Hormone receptor domain 7tm_2 PF00002.22 001270580.1_45729001_2 - 1.8e-95 318.7 10.0 2.7e-95 318.2 10.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 001270580.1_45729001_2 - 5.3e-26 90.6 1.7 5.3e-26 90.6 1.7 2.3 2 0 0 2 2 2 1 Hormone receptor domain VHS PF00790.17 001253859.1_45725001_1 - 1.6e-28 99.2 0.0 2.7e-28 98.4 0.0 1.4 1 0 0 1 1 1 1 VHS domain GAT PF03127.12 001253859.1_45725001_1 - 4.3e-17 62.1 2.4 8.3e-17 61.2 2.4 1.5 1 0 0 1 1 1 1 GAT domain Syntaxin-6_N PF09177.9 001271611.1_26223001_1 - 1.3e-27 96.1 0.0 4.2e-27 94.5 0.0 1.9 1 1 1 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.17 001271611.1_26223001_1 - 1.7e-12 47.0 2.0 4.5e-12 45.6 0.7 2.2 2 0 0 2 2 2 1 SNARE domain NDUF_B4 PF07225.10 001279553.1_24221001_1 - 4.6e-62 207.3 0.1 5.1e-62 207.2 0.1 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) An_peroxidase PF03098.13 001271261.1_45729001_3 - 1.7e-195 650.5 0.0 2.3e-195 650.1 0.0 1.2 1 0 0 1 1 1 1 Animal haem peroxidase I-set PF07679.14 001271261.1_45729001_3 - 1.8e-86 284.2 0.1 4e-22 78.0 0.0 4.3 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.4 001271261.1_45729001_3 - 1.9e-74 246.1 5.5 2.6e-18 66.3 0.2 4.6 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.4 001271261.1_45729001_3 - 1.1e-49 166.5 1.6 9e-12 45.0 0.0 4.6 4 0 0 4 4 4 4 Immunoglobulin domain LRR_8 PF13855.4 001271261.1_45729001_3 - 3e-40 135.6 22.0 7.9e-18 63.8 3.3 3.6 1 1 2 3 3 3 3 Leucine rich repeat ig PF00047.23 001271261.1_45729001_3 - 1.1e-39 134.3 0.6 2e-11 43.8 0.0 4.6 4 0 0 4 4 4 4 Immunoglobulin domain V-set PF07686.15 001271261.1_45729001_3 - 1.4e-20 73.3 11.6 0.00017 21.6 0.1 7.7 4 4 1 5 5 5 5 Immunoglobulin V-set domain C2-set_2 PF08205.10 001271261.1_45729001_3 - 5.8e-18 64.6 1.5 0.0018 18.1 0.0 4.6 4 0 0 4 4 4 4 CD80-like C2-set immunoglobulin domain LRR_4 PF12799.5 001271261.1_45729001_3 - 2.5e-15 56.1 10.0 2.8e-06 27.4 2.8 4.6 2 1 4 6 6 5 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001271261.1_45729001_3 - 1.9e-11 43.6 2.4 3.6e-06 26.5 0.5 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_5 PF13306.4 001271261.1_45729001_3 - 2.5e-11 43.5 0.0 7e-11 42.1 0.0 1.7 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) VWC PF00093.16 001271261.1_45729001_3 - 2.8e-07 30.6 19.2 2.8e-07 30.6 19.2 3.6 4 0 0 4 4 3 1 von Willebrand factor type C domain Sp38 PF07354.10 001271261.1_45729001_3 - 1.3e-06 27.3 0.0 0.062 12.0 0.0 3.3 3 0 0 3 3 3 2 Zona-pellucida-binding protein (Sp38) PSP94 PF05825.9 001271261.1_45729001_3 - 0.00015 22.1 8.0 0.00015 22.1 8.0 2.1 2 0 0 2 2 2 1 Beta-microseminoprotein (PSP-94) Izumo-Ig PF16706.3 001271261.1_45729001_3 - 0.00024 21.0 0.1 13 5.8 0.0 4.4 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain LRR_1 PF00560.31 001271261.1_45729001_3 - 0.011 16.0 10.3 12 6.7 0.1 6.3 4 1 1 5 5 5 0 Leucine Rich Repeat LRRCT PF01463.22 001271261.1_45729001_3 - 0.012 16.0 0.0 0.049 14.1 0.0 2.2 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain Amnionless PF14828.4 001271261.1_45729001_3 - 0.13 10.9 14.6 0.21 10.3 14.6 1.2 1 0 0 1 1 1 0 Amnionless Thymidylate_kin PF02223.15 207315.3_26227001_1 - 6.7e-17 61.6 0.0 1.5e-16 60.5 0.0 1.6 1 1 0 1 1 1 1 Thymidylate kinase AAA_33 PF13671.4 207315.3_26227001_1 - 9.6e-06 25.7 0.0 2.7e-05 24.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.4 207315.3_26227001_1 - 2.3e-05 24.8 0.1 0.00029 21.2 0.1 2.2 1 1 0 1 1 1 1 AAA domain dNK PF01712.17 207315.3_26227001_1 - 0.00054 19.7 0.0 0.00098 18.9 0.0 1.4 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_17 PF13207.4 207315.3_26227001_1 - 0.025 14.9 0.0 0.12 12.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain MltA PF03562.15 207315.3_26227001_1 - 0.18 11.4 0.0 0.29 10.7 0.0 1.2 1 0 0 1 1 1 0 MltA specific insert domain Complex1_LYR PF05347.13 001279731.1_24221001_1 - 2.4e-09 36.9 0.0 4.1e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.4 001279731.1_24221001_1 - 0.00024 21.6 0.0 0.00034 21.2 0.0 1.3 1 0 0 1 1 1 1 Complex1_LYR-like DUF4252 PF14060.4 001279731.1_24221001_1 - 0.07 12.9 0.2 0.1 12.4 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4252) CcmD PF04995.12 001279731.1_24221001_2 - 0.17 11.9 0.1 0.31 11.0 0.1 1.4 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) Zona_pellucida PF00100.21 001281602.1_31323001_2 - 4.1e-43 147.8 0.2 5.1e-43 147.5 0.2 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain Vitellogenin_N PF01347.20 001281608.1_31326001_2 - 1.9e-75 254.4 0.2 2.5e-75 254.0 0.2 1.1 1 0 0 1 1 1 1 Lipoprotein amino terminal region DUF4056 PF13265.4 001281608.1_31326001_2 - 0.055 12.7 0.0 0.1 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4056) FXa_inhibition PF14670.4 001271362.1_45726001_1 - 9.1e-52 172.9 191.0 9.2e-11 41.7 8.1 13.4 14 0 0 14 14 14 9 Coagulation Factor Xa inhibitory site cEGF PF12662.5 001271362.1_45726001_1 - 1e-39 134.0 91.1 2.3e-08 33.7 0.8 12.9 12 0 0 12 12 12 8 Complement Clr-like EGF-like Ephrin_rec_like PF07699.11 001271362.1_45726001_1 - 3.4e-37 125.8 50.1 3.3e-14 52.2 5.2 6.6 5 1 1 6 6 6 4 Putative ephrin-receptor like EGF_CA PF07645.13 001271362.1_45726001_1 - 1.2e-29 102.1 169.0 3.7e-09 36.5 8.9 12.0 12 2 1 13 13 13 6 Calcium-binding EGF domain CUB PF00431.18 001271362.1_45726001_1 - 2.2e-17 63.3 0.0 5.9e-17 61.9 0.0 1.8 1 0 0 1 1 1 1 CUB domain EGF_3 PF12947.5 001271362.1_45726001_1 - 1.2e-14 54.1 151.4 7.6e-10 38.7 10.5 11.9 12 0 0 12 12 12 8 EGF domain EGF PF00008.25 001271362.1_45726001_1 - 4.1e-09 36.4 149.9 3.8e-05 23.7 7.2 12.4 13 0 0 13 13 13 8 EGF-like domain hEGF PF12661.5 001271362.1_45726001_1 - 0.0016 18.9 1.4 0.0016 18.9 1.4 13.0 12 0 0 12 12 12 5 Human growth factor-like EGF KH_1 PF00013.27 001270598.1_45728001_2 - 2.3e-54 180.9 15.0 2.4e-14 52.8 0.3 4.4 4 0 0 4 4 4 4 KH domain RRM_1 PF00076.20 001270598.1_45728001_2 - 6.6e-17 61.0 0.0 4.3e-08 32.7 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_2 PF07650.15 001270598.1_45728001_2 - 1.1e-15 57.1 5.7 0.0037 16.9 0.2 4.6 4 0 0 4 4 4 4 KH domain KH_4 PF13083.4 001270598.1_45728001_2 - 7.3e-13 48.1 0.5 0.0025 17.5 0.0 4.6 4 0 0 4 4 4 4 KH domain KH_5 PF13184.4 001270598.1_45728001_2 - 0.00019 21.3 8.0 1.5 8.8 0.1 4.4 4 0 0 4 4 4 3 NusA-like KH domain MOEP19 PF16005.3 001270598.1_45728001_2 - 0.0065 16.3 0.0 0.46 10.4 0.0 3.2 3 0 0 3 3 3 1 KH-like RNA-binding domain DUF552 PF04472.10 001270598.1_45728001_2 - 0.045 13.9 0.1 3.8 7.7 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF552) Bromodomain PF00439.23 203367.2_45729001_2 - 9.3e-11 41.5 0.2 5.5e-10 39.0 0.0 2.3 2 0 0 2 2 2 1 Bromodomain PWWP PF00855.15 203367.2_45729001_2 - 8.2e-10 38.9 0.6 8.2e-10 38.9 0.6 3.2 2 1 0 2 2 2 1 PWWP domain DUF1002 PF06207.9 203367.2_45729001_2 - 0.14 11.6 1.0 0.33 10.3 1.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) PARM PF17061.3 203367.2_45729001_2 - 0.67 9.9 7.7 1.1 9.2 7.7 1.2 1 0 0 1 1 1 0 PARM Spore_III_AB PF09548.8 203367.2_45729001_2 - 2.5 8.1 6.9 1.7 8.6 4.7 1.8 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) HSP70 PF00012.18 203367.2_45729001_2 - 6.3 4.7 11.5 9.9 4.1 11.5 1.2 1 0 0 1 1 1 0 Hsp70 protein A2M_comp PF07678.12 001037975.2_45729001_2 - 8.6e-91 303.7 0.7 8.6e-91 303.7 0.7 1.6 2 0 0 2 2 2 1 A-macroglobulin complement component A2M_N_2 PF07703.12 001037975.2_45729001_2 - 6.9e-31 107.3 0.1 6.8e-28 97.6 0.1 3.2 2 1 0 2 2 2 2 Alpha-2-macroglobulin family N-terminal region A2M PF00207.20 001037975.2_45729001_2 - 3.7e-28 97.1 0.4 1.7e-27 95.0 0.1 2.4 2 0 0 2 2 2 1 Alpha-2-macroglobulin family A2M_recep PF07677.12 001037975.2_45729001_2 - 3.2e-26 91.8 0.5 1.2e-25 90.0 0.5 2.1 1 0 0 1 1 1 1 A-macroglobulin receptor A2M_N PF01835.17 001037975.2_45729001_2 - 2.1e-18 66.4 0.1 3e-17 62.7 0.0 3.2 2 1 1 3 3 3 1 MG2 domain Thiol-ester_cl PF10569.7 001037975.2_45729001_2 - 1.4e-16 59.7 1.5 3.8e-16 58.4 1.5 1.8 1 0 0 1 1 1 1 Alpha-macro-globulin thiol-ester bond-forming region CarboxypepD_reg PF13620.4 001037975.2_45729001_2 - 0.0015 18.6 1.3 0.02 15.0 0.0 3.0 3 0 0 3 3 3 1 Carboxypeptidase regulatory-like domain NDUF_C2 PF06374.9 001279694.1_24221001_1 - 2.6e-47 159.4 0.0 3e-47 159.2 0.0 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) HLH PF00010.24 001282299.1_31323001_3 - 2.4e-17 62.5 0.3 3.8e-17 61.8 0.3 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain HCO3_cotransp PF00955.19 001270795.1_45727001_2 - 2.6e-202 673.1 17.7 5.4e-128 427.9 6.1 2.1 1 1 1 2 2 2 2 HCO3- transporter family Band_3_cyto PF07565.11 001270795.1_45727001_2 - 3.5e-104 348.2 0.0 5.6e-104 347.6 0.0 1.3 1 0 0 1 1 1 1 Band 3 cytoplasmic domain Mu-transpos_C PF09299.9 001270795.1_45727001_2 - 0.051 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Mu transposase, C-terminal DUF3505 PF12013.6 001270795.1_45727001_2 - 0.069 13.5 0.2 0.18 12.1 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3505) RabGAP-TBC PF00566.16 001271410.1_45729001_2 - 2.3e-52 177.6 3.6 5.4e-52 176.4 3.6 1.7 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF1129 PF06570.9 001271410.1_45729001_2 - 0.0094 15.4 0.7 0.02 14.3 0.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1129) ETC_C1_NDUFA5 PF04716.12 001279755.1_24221001_1 - 2.3e-27 94.5 0.5 3.1e-27 94.0 0.5 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region Ndr PF03096.12 001271093.1_45726001_2 - 1.2e-122 407.9 0.0 1.5e-122 407.6 0.0 1.1 1 0 0 1 1 1 1 Ndr family DUF4209 PF13910.4 001278532.1_26224001_3 - 2.9e-30 104.2 0.7 3.2e-24 84.8 0.0 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF4209) Tmemb_18A PF09771.7 153261.5_26225001_3 - 1.6e-56 189.6 0.0 2.6e-56 189.0 0.0 1.3 1 0 0 1 1 1 1 Transmembrane protein 188 LIM PF00412.20 001244867.1_45721001_3 - 4.5e-15 55.5 6.5 6.8e-15 54.9 6.5 1.3 1 0 0 1 1 1 1 LIM domain DUF329 PF03884.12 001244867.1_45721001_3 - 0.039 13.5 2.9 2.6 7.7 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF329) Sgf11 PF08209.9 001244867.1_45721001_3 - 0.059 12.8 2.9 0.64 9.5 0.4 2.4 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Zn_Tnp_IS1595 PF12760.5 001244867.1_45721001_3 - 1.4 8.9 9.3 0.063 13.1 3.5 1.8 2 0 0 2 2 2 0 Transposase zinc-ribbon domain eIF-5a PF01287.18 001100697.2_45729001_3 - 1.7e-25 88.8 0.1 2.6e-25 88.2 0.1 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.10 001100697.2_45729001_3 - 0.1 12.5 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain dNK PF01712.17 001279649.1_24223001_1 - 4e-34 118.2 0.0 5.3e-34 117.7 0.0 1.1 1 0 0 1 1 1 1 Deoxynucleoside kinase Thymidylate_kin PF02223.15 001279649.1_24223001_1 - 0.0013 18.3 0.1 0.003 17.1 0.1 1.6 1 1 0 1 1 1 1 Thymidylate kinase AAA_17 PF13207.4 001279649.1_24223001_1 - 0.0035 17.6 0.2 1.1 9.5 0.1 2.3 2 0 0 2 2 2 2 AAA domain Cytidylate_kin PF02224.16 001279649.1_24223001_1 - 0.025 14.2 0.0 0.045 13.4 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase AAA_18 PF13238.4 001279649.1_24223001_1 - 0.045 14.1 0.0 0.26 11.7 0.0 2.1 1 1 0 1 1 1 0 AAA domain SKI PF01202.20 001279649.1_24223001_1 - 0.089 12.8 0.3 1.2 9.1 0.1 2.5 3 0 0 3 3 3 0 Shikimate kinase Actin PF00022.17 001281595.1_31323001_1 - 1.2e-151 504.9 0.0 3.8e-151 503.2 0.0 1.6 1 1 0 1 1 1 1 Actin ADK PF00406.20 030986.2_45722001_1 - 2.3e-61 206.2 0.0 2.9e-61 205.9 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.4 030986.2_45722001_1 - 7.3e-24 84.6 0.0 1.3e-23 83.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.12 030986.2_45722001_1 - 1.6e-16 59.8 0.0 4.8e-16 58.3 0.0 1.9 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.4 030986.2_45722001_1 - 2e-05 24.6 0.0 0.00083 19.4 0.0 2.1 1 1 1 2 2 2 1 AAA domain Cytidylate_kin PF02224.16 030986.2_45722001_1 - 0.015 14.9 0.0 0.024 14.3 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA_18 PF13238.4 030986.2_45722001_1 - 0.026 14.9 0.0 0.046 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Aminotran_3 PF00202.19 030986.2_45722001_1 - 0.04 12.4 0.0 0.058 11.9 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-III AAA_28 PF13521.4 030986.2_45722001_1 - 0.047 13.8 0.0 0.24 11.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain 7tm_1 PF00001.19 001282298.1_31323001_3 - 1.1e-29 103.4 29.4 7.6e-28 97.3 29.4 2.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001282298.1_31323001_3 - 2.3e-11 43.5 21.3 1.2e-09 37.8 21.3 2.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001282298.1_31323001_3 - 8.5e-06 25.6 17.3 4.9e-05 23.1 11.5 2.4 1 1 1 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001282298.1_31323001_3 - 1.3e-05 24.5 13.5 1.3e-05 24.5 13.5 2.3 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.7 001282298.1_31323001_3 - 0.52 9.4 27.8 0.27 10.4 6.1 2.1 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srw DAD PF02109.14 001281624.1_31321001_3 - 1.4e-47 160.4 1.7 1.6e-47 160.2 1.7 1.0 1 0 0 1 1 1 1 DAD family Kazal_2 PF07648.13 001257093.1_39523001_1 - 3.2e-36 123.1 32.3 1.2e-13 50.9 1.6 4.6 4 1 0 4 4 4 3 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 001257093.1_39523001_1 - 1.6e-19 69.5 35.3 2.9e-07 30.3 4.4 3.9 3 0 0 3 3 3 3 Kazal-type serine protease inhibitor domain FOLN PF09289.8 001257093.1_39523001_1 - 4.6e-07 29.8 12.7 4.6e-07 29.8 12.7 4.6 4 1 0 4 4 4 1 Follistatin/Osteonectin-like EGF domain DUF4749 PF15936.3 001277158.1_45723001_3 - 5.4e-26 91.5 0.3 1.1e-25 90.5 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) PDZ PF00595.22 001277158.1_45723001_3 - 2.8e-16 59.5 0.0 6e-16 58.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001277158.1_45723001_3 - 5.9e-05 23.2 0.0 0.00014 22.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain DUF3854 PF12965.5 001277158.1_45723001_3 - 0.067 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3854) Sema PF01403.17 001256348.1_26229001_1 - 4.5e-133 444.0 0.0 7.4e-133 443.3 0.0 1.3 1 0 0 1 1 1 1 Sema domain TSP_1 PF00090.17 001256348.1_26229001_1 - 1.9e-31 107.9 80.7 1.7e-10 40.8 5.7 7.5 6 1 0 6 6 6 5 Thrombospondin type 1 domain PSI PF01437.23 001256348.1_26229001_1 - 5.7e-08 33.0 5.3 5.7e-08 33.0 5.3 4.3 5 0 0 5 5 5 1 Plexin repeat SEA PF01390.18 001281655.1_31325001_1 - 2.2e-13 50.3 0.9 3.9e-13 49.5 0.9 1.4 1 0 0 1 1 1 1 SEA domain DUF4381 PF14316.4 001281655.1_31325001_1 - 0.0044 17.2 0.2 0.0078 16.3 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) Kunitz_BPTI PF00014.21 001281655.1_31325001_3 - 0.024 14.7 26.9 5.7 7.1 0.5 8.7 3 1 6 10 10 10 0 Kunitz/Bovine pancreatic trypsin inhibitor domain 7tm_1 PF00001.19 001271854.1_26229001_3 - 1.3e-24 86.7 22.8 2.1e-24 86.1 22.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) IQ_SEC7_PH PF16453.3 001277425.1_45729001_1 - 7e-64 213.8 0.6 1.5e-63 212.8 0.3 1.8 2 0 0 2 2 2 1 PH domain Sec7 PF01369.18 001277425.1_45729001_1 - 8.4e-56 188.5 0.0 1.5e-55 187.7 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain SlyX PF04102.10 001277425.1_45729001_1 - 0.19 12.2 5.3 1.2 9.7 5.3 2.5 1 0 0 1 1 1 0 SlyX Atg14 PF10186.7 001277425.1_45729001_1 - 1 8.2 5.2 2.4 7.0 5.2 1.6 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 SelP_N PF04592.12 001277425.1_45729001_1 - 7.3 5.8 6.9 20 4.3 6.9 1.7 1 0 0 1 1 1 0 Selenoprotein P, N terminal region 3Beta_HSD PF01073.17 001279701.1_24223001_1 - 1.2e-10 40.7 0.0 1.6e-07 30.4 0.0 2.2 1 1 1 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 001279701.1_24223001_1 - 2.7e-10 40.0 0.0 4.9e-09 35.9 0.0 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.11 001279701.1_24223001_1 - 2.9e-09 36.7 0.0 5.9e-09 35.7 0.0 1.4 2 0 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.4 001279701.1_24223001_1 - 2.3e-08 34.0 0.1 4.5e-08 33.1 0.0 1.5 2 0 0 2 2 2 1 NAD(P)H-binding RmlD_sub_bind PF04321.15 001279701.1_24223001_1 - 0.00013 21.0 0.0 0.17 10.8 0.0 2.3 2 0 0 2 2 2 2 RmlD substrate binding domain NAD_binding_4 PF07993.10 001279701.1_24223001_1 - 0.00018 20.6 0.0 0.32 10.0 0.0 2.8 2 1 1 3 3 3 2 Male sterility protein GDP_Man_Dehyd PF16363.3 001279701.1_24223001_1 - 0.0017 17.7 0.0 0.0023 17.2 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase adh_short PF00106.23 001279701.1_24223001_1 - 0.13 11.6 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase 7tm_1 PF00001.19 001281538.1_31322001_1 - 2.9e-19 69.2 0.0 4.6e-19 68.6 0.0 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Cytochrome_B PF00033.17 001281538.1_31322001_1 - 0.015 15.0 0.2 0.028 14.1 0.2 1.4 1 0 0 1 1 1 0 Cytochrome b/b6/petB DUF2705 PF10920.6 001281538.1_31322001_1 - 0.23 10.7 0.0 0.36 10.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2705) Exo_endo_phos PF03372.21 053632.1_45727001_3 - 5.3e-07 29.8 0.0 8.4e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family NnrU PF07298.9 001281696.1_31324001_1 - 0.07 12.5 0.3 0.16 11.3 0.0 1.7 2 0 0 2 2 2 0 NnrU protein Homeobox PF00046.27 001281696.1_31324001_2 - 5.9e-21 73.9 1.2 1.1e-20 73.0 1.2 1.4 1 0 0 1 1 1 1 Homeobox domain Tetraspannin PF00335.18 012523.2_45724001_1 - 6e-50 169.8 21.7 8.2e-50 169.4 21.7 1.2 1 0 0 1 1 1 1 Tetraspanin family 7tm_1 PF00001.19 001278475.1_45724001_2 - 2.8e-16 59.4 0.0 4.7e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4231 PF14015.4 001278475.1_45724001_2 - 0.71 10.2 2.0 6.8 7.1 0.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) 7tm_1 PF00001.19 021857.3_45723001_3 - 2.1e-71 240.2 7.1 3.1e-71 239.6 7.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 021857.3_45723001_3 - 1.3e-08 34.4 12.6 7.3e-08 32.0 12.6 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 021857.3_45723001_3 - 1.1e-05 24.8 8.8 0.033 13.4 6.0 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.7 021857.3_45723001_3 - 0.0013 18.0 9.8 0.0013 18.0 9.8 2.4 2 2 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF2208 PF09973.7 021857.3_45723001_3 - 0.14 11.6 9.3 0.71 9.3 0.2 2.7 3 0 0 3 3 3 0 Predicted membrane protein (DUF2208) DUF2207 PF09972.7 021857.3_45723001_3 - 0.52 8.9 7.3 0.64 8.6 0.0 2.7 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) NCU-G1 PF15065.4 001256604.1_26223001_3 - 3.7e-81 272.8 0.1 8.2e-58 196.0 0.0 2.0 1 1 1 2 2 2 2 Lysosomal transcription factor, NCU-G1 Trypsin PF00089.24 001281660.1_31326001_2 - 3.9e-61 206.5 0.0 5.7e-61 206.0 0.0 1.3 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 001281660.1_31326001_2 - 1.6e-42 144.2 0.2 5.4e-23 81.3 0.0 2.4 2 0 0 2 2 2 2 CUB domain Sushi PF00084.18 001281660.1_31326001_2 - 2.7e-15 56.6 6.1 3.4e-07 30.7 0.8 2.9 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) FXa_inhibition PF14670.4 001281660.1_31326001_2 - 1e-08 35.2 6.0 3.3e-08 33.5 6.0 2.0 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site EGF_CA PF07645.13 001281660.1_31326001_2 - 4.9e-05 23.3 8.5 4.9e-05 23.3 8.5 2.4 2 0 0 2 2 2 1 Calcium-binding EGF domain CUB_2 PF02408.18 001281660.1_31326001_2 - 0.00044 19.9 0.4 0.18 11.5 0.1 2.4 2 0 0 2 2 2 2 CUB-like domain Trypsin_2 PF13365.4 001281660.1_31326001_2 - 0.0014 19.4 0.0 0.0024 18.6 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain HRM PF02793.20 001281660.1_31326001_2 - 0.042 14.0 11.6 0.038 14.1 1.2 3.0 3 0 0 3 3 3 0 Hormone receptor domain EGF PF00008.25 001281660.1_31326001_2 - 0.079 13.2 8.5 0.42 10.8 8.5 2.4 1 0 0 1 1 1 0 EGF-like domain MAP7 PF05672.9 001271327.1_45726001_1 - 1e-05 25.2 23.8 1e-05 25.2 23.8 3.4 2 1 1 3 3 3 2 MAP7 (E-MAP-115) family PC_rep PF01851.20 001278708.1_26226001_1 - 2.9e-26 90.4 22.0 2e-06 27.8 0.2 8.3 9 0 0 9 9 9 5 Proteasome/cyclosome repeat HEAT_2 PF13646.4 001278708.1_26226001_1 - 0.00019 21.6 0.0 0.15 12.3 0.0 3.8 3 1 1 4 4 4 1 HEAT repeats THAP PF05485.10 001278708.1_26226001_1 - 0.034 15.0 0.4 0.081 13.8 0.4 1.5 1 0 0 1 1 1 0 THAP domain cwf21 PF08312.10 001277154.1_45729001_1 - 3.3e-10 39.8 10.8 7.1e-10 38.7 10.8 1.6 1 0 0 1 1 1 1 cwf21 domain CTD PF12815.5 001277154.1_45729001_1 - 0.00026 21.4 6.4 0.00026 21.4 6.4 16.1 7 5 3 11 11 11 3 Spt5 C-terminal nonapeptide repeat binding Spt4 AAA_11 PF13086.4 001281389.1_31327001_2 - 5.2e-56 190.1 1.9 1.7e-55 188.5 1.9 1.9 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.4 001281389.1_31327001_2 - 4.9e-54 182.9 0.0 3.2e-53 180.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.4 001281389.1_31327001_2 - 7.4e-15 55.0 0.4 1.6e-10 40.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain R3H PF01424.20 001281389.1_31327001_2 - 1.7e-11 43.8 0.3 3.8e-11 42.7 0.3 1.6 1 0 0 1 1 1 1 R3H domain AAA_19 PF13245.4 001281389.1_31327001_2 - 3.2e-11 43.6 0.0 1.1e-10 41.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.16 001281389.1_31327001_2 - 1.6e-07 31.2 0.2 0.34 10.5 0.0 3.6 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase zf-AN1 PF01428.14 001281389.1_31327001_2 - 3e-07 30.4 9.3 6.5e-07 29.3 9.3 1.6 1 0 0 1 1 1 1 AN1-like Zinc finger ResIII PF04851.13 001281389.1_31327001_2 - 4.3e-06 26.7 0.0 1.9e-05 24.6 0.0 2.0 2 1 0 2 2 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.12 001281389.1_31327001_2 - 1.1e-05 25.3 0.5 0.004 16.9 0.3 3.5 2 1 0 2 2 2 1 Helicase DEAD PF00270.27 001281389.1_31327001_2 - 1.5e-05 24.7 0.6 5e-05 23.0 0.2 2.0 1 1 1 2 2 2 1 DEAD/DEAH box helicase UvrD-helicase PF00580.19 001281389.1_31327001_2 - 0.00025 20.5 0.2 0.00098 18.6 0.2 1.9 1 1 1 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_25 PF13481.4 001281389.1_31327001_2 - 0.00078 18.9 0.0 0.0022 17.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.4 001281389.1_31327001_2 - 0.00091 19.5 0.7 0.0025 18.1 0.1 2.0 2 0 0 2 2 1 1 AAA ATPase domain AAA_22 PF13401.4 001281389.1_31327001_2 - 0.00094 19.3 0.1 0.0057 16.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.7 001281389.1_31327001_2 - 0.0013 17.9 2.1 0.038 13.1 2.1 2.8 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.15 001281389.1_31327001_2 - 0.0033 17.1 0.0 0.0078 15.9 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA PF00004.27 001281389.1_31327001_2 - 0.0035 17.7 1.0 0.011 16.0 1.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Flavi_DEAD PF07652.12 001281389.1_31327001_2 - 0.0057 16.5 0.1 0.015 15.1 0.1 1.7 1 0 0 1 1 1 1 Flavivirus DEAD domain PhoH PF02562.14 001281389.1_31327001_2 - 0.0066 15.8 0.6 0.021 14.2 0.0 2.0 2 0 0 2 2 2 1 PhoH-like protein T2SSE PF00437.18 001281389.1_31327001_2 - 0.014 14.3 0.0 0.025 13.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Zot PF05707.10 001281389.1_31327001_2 - 0.017 14.6 0.2 0.074 12.6 0.1 2.1 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) UvrD_C_2 PF13538.4 001281389.1_31327001_2 - 0.018 14.7 0.1 0.052 13.2 0.1 1.8 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain ABC_tran PF00005.25 001281389.1_31327001_2 - 0.025 15.0 0.2 0.082 13.3 0.2 1.9 1 1 0 1 1 1 0 ABC transporter AAA_33 PF13671.4 001281389.1_31327001_2 - 0.046 13.8 0.6 0.41 10.7 0.6 2.7 1 1 0 1 1 1 0 AAA domain VWA_2 PF13519.4 001281389.1_31327001_2 - 0.14 12.7 0.2 0.47 11.0 0.2 1.9 1 0 0 1 1 1 0 von Willebrand factor type A domain AAA_23 PF13476.4 001281389.1_31327001_2 - 0.18 12.1 6.7 5.2 7.4 0.0 3.0 3 0 0 3 3 3 0 AAA domain HSA PF07529.11 001281389.1_31327001_2 - 6.3 7.1 7.2 0.32 11.2 0.7 2.2 2 0 0 2 2 1 0 HSA LRR_6 PF13516.4 001270762.1_45724001_2 - 6.7e-38 125.4 31.6 3.9e-05 23.2 0.4 11.9 12 0 0 12 12 12 9 Leucine Rich repeat LRR_4 PF12799.5 001270762.1_45724001_2 - 1.8e-10 40.7 29.9 0.12 12.7 0.9 9.4 6 3 4 10 10 10 5 Leucine Rich repeats (2 copies) Pentapeptide_4 PF13599.4 001270762.1_45724001_2 - 0.0003 20.7 1.9 3.4 7.7 0.0 4.9 4 2 0 4 4 4 2 Pentapeptide repeats (9 copies) LRR_8 PF13855.4 001270762.1_45724001_2 - 0.00053 19.6 20.6 3.7 7.3 0.2 8.1 6 2 1 7 7 7 3 Leucine rich repeat LRR_1 PF00560.31 001270762.1_45724001_2 - 0.00057 19.8 33.9 2 9.1 0.1 11.1 13 0 0 13 13 13 2 Leucine Rich Repeat Sema PF01403.17 053471.2_45728001_3 - 2.6e-125 418.4 0.0 3.9e-125 417.8 0.0 1.1 1 0 0 1 1 1 1 Sema domain DUF1049 PF06305.9 053471.2_45728001_3 - 0.0077 15.9 0.4 0.018 14.8 0.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1049) SH2 PF00017.22 001282965.1_26227001_1 - 3.3e-19 68.6 0.1 5.9e-19 67.8 0.1 1.4 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 001282965.1_26227001_1 - 4.2e-05 22.9 0.0 8e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 001282965.1_26227001_1 - 0.00023 20.8 0.4 0.0035 17.0 0.0 2.4 2 0 0 2 2 2 1 Variant SH3 domain Esterase PF00756.18 001270865.1_45723001_1 - 8.8e-70 235.1 0.0 1.1e-69 234.8 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Chlorophyllase2 PF12740.5 001270865.1_45723001_1 - 0.00013 20.9 0.0 0.00018 20.4 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Peptidase_S9 PF00326.19 001270865.1_45723001_1 - 0.00014 21.3 0.0 0.00021 20.7 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase_phd PF10503.7 001270865.1_45723001_1 - 0.00019 20.8 0.0 0.0017 17.7 0.0 2.0 1 1 0 1 1 1 1 Esterase PHB depolymerase AXE1 PF05448.10 001270865.1_45723001_1 - 0.00031 19.4 0.0 0.00044 18.9 0.0 1.2 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) Hydrolase_4 PF12146.6 001270865.1_45723001_1 - 0.0005 19.3 0.0 0.00072 18.8 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.14 001270865.1_45723001_1 - 0.0093 15.6 0.0 0.015 15.0 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.11 001270865.1_45723001_1 - 0.018 14.7 0.0 0.035 13.8 0.0 1.4 2 0 0 2 2 2 0 alpha/beta hydrolase fold Lipase_3 PF01764.23 001270865.1_45723001_1 - 0.037 13.8 0.0 0.058 13.1 0.0 1.2 1 0 0 1 1 1 0 Lipase (class 3) Chlorophyllase PF07224.9 001270865.1_45723001_1 - 0.13 11.1 0.0 0.41 9.5 0.0 1.6 2 0 0 2 2 2 0 Chlorophyllase Glyco_hydro_47 PF01532.18 001109196.1_45728001_3 - 1e-163 545.4 0.0 1.2e-163 545.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 NADHdh_A3 PF14987.4 001251975.1_39721001_1 - 1.4e-49 166.2 2.0 1.6e-49 166.1 2.0 1.0 1 0 0 1 1 1 1 NADH dehydrogenase 1 alpha subcomplex subunit 3 CD20 PF04103.13 001270590.1_45723001_3 - 1.3e-38 132.4 13.6 1.7e-38 132.0 13.6 1.2 1 0 0 1 1 1 1 CD20-like family DUF4083 PF13314.4 001270590.1_45723001_3 - 0.023 14.5 0.3 0.05 13.4 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) PAS_11 PF14598.4 001281567.1_31324001_1 - 3.8e-26 91.3 0.2 3e-22 78.7 0.1 2.4 2 0 0 2 2 2 2 PAS domain PAS PF00989.23 001281567.1_31324001_1 - 5.4e-21 74.6 0.0 2.5e-09 37.0 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_3 PF08447.10 001281567.1_31324001_1 - 5.2e-20 71.4 0.0 7.2e-12 45.3 0.0 2.4 2 0 0 2 2 2 2 PAS fold HLH PF00010.24 001281567.1_31324001_1 - 1.7e-17 63.0 0.8 3.3e-17 62.0 0.8 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.5 001281567.1_31324001_1 - 9.8e-09 35.3 0.0 4.6e-05 23.5 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.8 001281567.1_31324001_1 - 2.2e-05 24.5 0.0 0.0082 16.2 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_2 PF08446.9 001281567.1_31324001_1 - 0.022 15.3 0.0 0.087 13.4 0.0 1.9 2 0 0 2 2 2 0 PAS fold NDUF_B5 PF09781.7 001279594.1_24222001_1 - 4.3e-88 293.7 0.0 4.8e-88 293.5 0.0 1.0 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit DUF3749 PF12568.6 001279594.1_24222001_1 - 0.12 12.0 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Tim17 PF02466.17 032618.1_45724001_1 - 1.7e-28 98.9 6.6 2.9e-28 98.1 6.6 1.4 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family LBP_BPI_CETP PF01273.23 001077680.1_45724001_1 - 9.8e-25 86.9 1.9 9.8e-25 86.9 1.9 1.6 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain LBP_BPI_CETP_C PF02886.15 001077680.1_45724001_1 - 2.8e-08 33.4 5.4 5.6e-08 32.4 0.1 2.5 2 1 0 2 2 2 1 LBP / BPI / CETP family, C-terminal domain HAP PF03866.11 001077680.1_45724001_1 - 0.0036 17.2 0.3 0.0075 16.2 0.3 1.6 1 0 0 1 1 1 1 Hydrophobic abundant protein (HAP) zf-C3HC4_2 PF13923.4 001127597.2_45727001_1 - 1.1e-06 28.2 13.9 2.5e-06 27.1 13.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001127597.2_45727001_1 - 1.1e-06 28.2 13.9 2.9e-06 26.9 13.9 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 001127597.2_45727001_1 - 5.7e-06 26.0 9.9 5.7e-06 26.0 9.9 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.4 001127597.2_45727001_1 - 1.3e-05 24.8 13.6 1.3e-05 24.8 13.6 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001127597.2_45727001_1 - 7.1e-05 22.6 12.1 0.00018 21.2 12.1 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 001127597.2_45727001_1 - 0.00019 21.2 10.9 0.00049 19.9 10.9 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 001127597.2_45727001_1 - 0.00047 20.1 15.1 0.001 19.1 15.1 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.4 001127597.2_45727001_1 - 0.0014 18.7 16.3 0.0033 17.5 16.3 1.7 1 0 0 1 1 1 1 Ring finger domain U-box PF04564.13 001127597.2_45727001_1 - 0.044 13.8 0.1 6.5 6.9 0.0 2.4 2 0 0 2 2 2 0 U-box domain zf-RING_4 PF14570.4 001127597.2_45727001_1 - 1.4 8.6 12.6 0.048 13.3 6.0 1.9 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Menin PF05053.11 001127597.2_45727001_1 - 1.5 6.9 9.6 2.9 6.0 9.6 1.3 1 0 0 1 1 1 0 Menin zf-RING_6 PF14835.4 001127597.2_45727001_1 - 5.5 6.8 8.5 11 5.9 8.5 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein GRIM-19 PF06212.10 001279754.1_24221001_1 - 5.6e-51 171.8 0.0 6.5e-51 171.6 0.0 1.0 1 0 0 1 1 1 1 GRIM-19 protein COX14 PF14880.4 001279754.1_24221001_1 - 0.036 13.8 0.0 0.06 13.1 0.0 1.4 1 0 0 1 1 1 0 Cytochrome oxidase c assembly PDEase_I PF00233.17 001258314.1_26225001_3 - 2.2e-81 272.9 4.8 3.7e-81 272.2 4.8 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase PDEase_I_N PF08499.10 001258314.1_26225001_3 - 4.7e-32 109.5 0.1 8.9e-32 108.6 0.1 1.5 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase N-terminal Roc PF08477.11 001283136.1_29524001_2 - 5.3e-14 52.3 0.0 7.8e-14 51.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001283136.1_29524001_2 - 2.8e-10 39.9 0.0 4e-10 39.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Arf PF00025.19 001283136.1_29524001_2 - 9.7e-08 31.5 0.0 1.4e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001283136.1_29524001_2 - 2.5e-05 23.7 0.0 3.8e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.10 001283136.1_29524001_2 - 0.0084 15.4 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.18 001283136.1_29524001_2 - 0.0085 15.2 0.0 0.47 9.4 0.0 2.5 1 1 1 2 2 2 1 G-protein alpha subunit PduV-EutP PF10662.7 001283136.1_29524001_2 - 0.06 13.0 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Cep57_MT_bd PF06657.11 001283136.1_29524001_2 - 0.14 12.5 0.1 0.26 11.6 0.1 1.4 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 MMR_HSR1 PF01926.21 001283136.1_29524001_2 - 0.17 11.8 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase Pkinase_Tyr PF07714.15 032237.4_26224001_1 - 1.9e-09 37.1 0.1 1.6e-08 34.0 0.1 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.23 032237.4_26224001_1 - 1.8e-05 24.1 0.3 0.00012 21.5 0.1 2.1 1 1 1 2 2 2 1 Protein kinase domain PIP49_C PF12260.6 032237.4_26224001_1 - 0.061 12.8 0.1 0.1 12.1 0.1 1.4 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 NDUF_B8 PF05821.9 001279724.1_24222001_1 - 2.4e-77 258.7 6.5 2.7e-77 258.5 6.5 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) Glucosamine_iso PF01182.18 001281599.1_31323001_3 - 4.7e-18 65.8 0.0 7.5e-18 65.1 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 7tm_1 PF00001.19 001281948.1_31325001_1 - 1.8e-71 240.4 12.8 2.3e-71 240.0 12.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001281948.1_31325001_1 - 5.5e-15 55.3 15.0 8e-15 54.8 15.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001281948.1_31325001_1 - 1.4e-08 34.7 8.9 1.4e-08 34.7 8.9 2.0 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001281948.1_31325001_1 - 1.9e-05 24.0 14.8 3.3e-05 23.2 14.8 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Peptidase_S8 PF00082.20 001267753.1_08025001_1 - 5.3e-24 84.9 0.1 1.5e-23 83.4 0.1 1.6 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.14 001267753.1_08025001_1 - 2.6e-06 27.8 0.0 4.3e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 WD40 PF00400.30 001271306.1_45728001_3 - 5e-19 68.2 9.1 7.8e-05 23.2 0.0 6.7 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001271306.1_45728001_3 - 7.5e-11 42.0 0.0 0.035 14.3 0.0 4.3 2 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Dynein_IC2 PF11540.6 001270624.1_45726001_1 - 1.2e-15 57.0 0.6 2.5e-15 56.0 0.6 1.6 1 0 0 1 1 1 1 Cytoplasmic dynein 1 intermediate chain 2 WD40 PF00400.30 001270624.1_45726001_1 - 2.2e-05 25.0 11.7 0.21 12.4 0.6 6.7 7 0 0 7 7 7 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001270624.1_45726001_1 - 0.005 17.0 0.1 0.055 13.6 0.0 2.6 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain zf-H2C2_2 PF13465.4 017364.4_45728001_1 - 4.1e-77 251.3 89.3 4.4e-09 36.2 0.1 14.5 15 0 0 15 15 13 13 Zinc-finger double domain zf-C2H2 PF00096.24 017364.4_45728001_1 - 2.8e-67 219.5 95.1 2.6e-06 27.4 2.1 14.8 14 0 0 14 14 14 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 017364.4_45728001_1 - 2.2e-37 124.4 90.6 0.003 18.1 2.4 14.6 14 0 0 14 14 14 13 C2H2-type zinc finger zf-C2H2_6 PF13912.4 017364.4_45728001_1 - 2.2e-17 62.4 73.5 0.01 15.6 1.8 13.7 13 0 0 13 13 13 11 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 017364.4_45728001_1 - 3.1e-11 43.1 65.1 0.023 14.7 1.4 9.4 4 3 7 11 11 11 10 Zinc ribbon domain zf-C2H2_jaz PF12171.6 017364.4_45728001_1 - 7.6e-06 26.0 52.2 0.096 12.9 1.8 11.0 11 0 0 11 11 11 4 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 017364.4_45728001_1 - 0.00012 22.6 53.7 0.15 12.7 4.3 7.8 1 1 7 10 10 10 6 zinc-ribbon family zf-C2H2_11 PF16622.3 017364.4_45728001_1 - 0.00093 18.8 60.7 0.049 13.3 0.1 13.3 13 0 0 13 13 13 4 zinc-finger C2H2-type XPA_N PF01286.16 017364.4_45728001_1 - 0.08 12.9 56.3 7.2 6.6 0.1 13.1 13 0 0 13 13 13 0 XPA protein N-terminal C1_4 PF07975.10 017364.4_45728001_1 - 1.9 8.7 59.8 0.57 10.3 1.0 9.6 5 2 6 11 11 11 0 TFIIH C1-like domain LIM PF00412.20 017364.4_45728001_1 - 4.7 7.4 56.0 0.19 11.8 2.5 8.4 4 2 1 8 8 8 0 LIM domain Connexin PF00029.17 001281548.1_31324001_1 - 2.4e-99 331.5 0.3 4.3e-99 330.7 0.3 1.4 1 0 0 1 1 1 1 Connexin TLP-20 PF06088.9 001281548.1_31324001_1 - 0.038 13.7 0.0 0.076 12.8 0.0 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Connexin40_C PF16791.3 001281548.1_31324001_1 - 1 10.5 5.0 0.23 12.6 0.3 2.0 2 0 0 2 2 2 0 Connexin 40 C-terminal domain Ion_trans PF00520.29 001281849.1_31329001_1 - 3.1e-258 851.8 81.7 2.7e-72 242.8 13.5 4.1 4 0 0 4 4 4 4 Ion transport protein CAC1F_C PF16885.3 001281849.1_31329001_1 - 5.8e-67 226.8 1.9 5.8e-67 226.8 1.9 2.7 2 1 0 2 2 2 1 Voltage-gated calcium channel subunit alpha, C-term GPHH PF16905.3 001281849.1_31329001_1 - 5.4e-36 122.1 0.0 1.4e-35 120.8 0.0 1.8 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 001281849.1_31329001_1 - 9.8e-31 105.7 0.1 2.3e-30 104.5 0.1 1.7 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 001281849.1_31329001_1 - 3.8e-10 38.9 8.8 6.3e-10 38.2 5.9 8.9 7 3 1 8 8 8 4 Polycystin cation channel Rer1 PF03248.11 001281849.1_31329001_1 - 0.16 11.6 9.1 1 9.0 2.0 4.4 4 0 0 4 4 4 0 Rer1 family NARP1 PF12569.6 001281849.1_31329001_1 - 2.9 6.5 5.4 6.3 5.4 5.4 1.5 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 EphA2_TM PF14575.4 001281849.1_31329001_1 - 7.4 7.3 7.5 19 6.0 0.1 5.2 5 0 0 5 5 5 0 Ephrin type-A receptor 2 transmembrane domain Tropomodulin PF03250.12 001106449.2_45723001_2 - 2e-59 199.5 5.1 3.7e-59 198.7 5.1 1.4 1 0 0 1 1 1 1 Tropomodulin LRR_6 PF13516.4 001106449.2_45723001_2 - 0.99 9.5 3.3 0.99 9.5 0.1 2.6 3 0 0 3 3 3 0 Leucine Rich repeat Skp1_POZ PF03931.13 001270561.1_45725001_1 - 7.8e-10 38.7 0.0 1.2e-09 38.1 0.0 1.3 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain A1_Propeptide PF07966.10 001270561.1_45725001_2 - 0.082 12.7 1.7 0.14 11.9 1.7 1.4 1 0 0 1 1 1 0 A1 Propeptide Complex1_LYR PF05347.13 001279728.1_24222001_1 - 9.5e-12 44.7 3.3 9.5e-12 44.7 3.3 1.9 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.4 001279728.1_24222001_1 - 8.3e-05 23.1 1.1 8.3e-05 23.1 1.1 1.6 2 0 0 2 2 2 1 Complex1_LYR-like ImpA_N PF06812.10 001279728.1_24222001_1 - 0.014 15.3 0.5 0.045 13.7 0.0 2.0 1 1 1 2 2 2 0 ImpA, N-terminal, type VI secretion system Pou PF00157.15 001281822.1_31323001_1 - 1.1e-38 131.0 0.3 1.8e-38 130.3 0.3 1.4 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 001281822.1_31323001_1 - 2.4e-18 65.6 1.5 7.5e-18 64.0 0.3 2.1 2 0 0 2 2 2 1 Homeobox domain HTH_31 PF13560.4 001281822.1_31323001_1 - 0.015 15.5 0.0 0.065 13.4 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain Homeobox_KN PF05920.9 001281822.1_31323001_1 - 0.046 13.5 0.2 0.15 11.8 0.0 1.9 2 0 0 2 2 2 0 Homeobox KN domain WD40 PF00400.30 001281589.1_31324001_1 - 3.9e-22 78.0 10.8 4.8e-05 23.9 0.1 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001281589.1_31324001_1 - 1.4e-05 25.2 0.0 7.7 6.8 0.0 5.0 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain B_lectin PF01453.22 001281589.1_31324001_1 - 0.12 12.3 0.0 0.34 10.8 0.0 1.7 2 0 0 2 2 2 0 D-mannose binding lectin CENP-L PF13092.4 001033061.2_45724001_3 - 2.9e-32 112.0 0.1 4.7e-32 111.3 0.1 1.3 1 0 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 PIG-Y PF15159.4 001271975.1_45724001_1 - 1.2e-16 61.1 2.3 1.2e-16 61.1 2.3 1.6 2 0 0 2 2 2 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y tRNA-synt_2c PF01411.17 001281677.1_31326001_1 - 9.3e-225 747.2 0.0 1.3e-224 746.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.12 001281677.1_31326001_1 - 2.7e-17 62.4 0.0 6.1e-17 61.3 0.0 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.17 001281677.1_31326001_1 - 1.8e-11 43.7 0.0 5.8e-11 42.1 0.0 1.9 1 0 0 1 1 1 1 DHHA1 domain Syntaxin-6_N PF09177.9 001281677.1_31326001_1 - 0.37 11.3 3.7 1.1 9.8 3.7 1.8 1 1 0 1 1 1 0 Syntaxin 6, N-terminal RRM_1 PF00076.20 001271138.1_45723001_1 - 1.2e-17 63.3 0.0 1.9e-17 62.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.9 001271138.1_45723001_1 - 1.7e-05 24.6 0.1 4.3e-05 23.4 0.0 1.6 2 0 0 2 2 2 1 RNA binding motif RRM_5 PF13893.4 001271138.1_45723001_1 - 0.0012 18.3 0.0 0.0019 17.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRICHOS PF04089.12 001283702.1_29524001_3 - 4.5e-20 71.4 0.0 1e-19 70.3 0.0 1.6 1 0 0 1 1 1 1 BRICHOS domain zf-CHCC PF10276.7 001279713.1_24221001_1 - 5.1e-18 64.7 0.7 8.2e-18 64.1 0.7 1.4 1 0 0 1 1 1 1 Zinc-finger domain Thiolase_C PF02803.16 001279713.1_24221001_1 - 0.022 14.3 0.0 0.041 13.4 0.0 1.3 1 0 0 1 1 1 0 Thiolase, C-terminal domain SNF PF00209.16 172890.3_32929001_1 - 4.9e-247 820.6 36.5 6.1e-247 820.3 36.5 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family START PF01852.17 001281682.1_31324001_2 - 2.5e-53 180.4 0.0 3.6e-53 180.0 0.0 1.2 1 0 0 1 1 1 1 START domain Polyketide_cyc PF03364.18 001281682.1_31324001_2 - 0.045 13.8 0.0 0.16 12.1 0.0 1.9 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport Fer4 PF00037.25 001279707.1_24222001_1 - 3.7e-14 51.7 17.5 1.4e-08 34.0 4.5 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.5 001279707.1_24222001_1 - 8.4e-13 48.6 10.5 1.5e-12 47.8 10.5 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.4 001279707.1_24222001_1 - 6.3e-11 42.9 6.8 3.3e-05 24.6 0.2 2.3 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.4 001279707.1_24222001_1 - 2.2e-09 37.2 31.8 7.6e-06 25.8 12.6 2.2 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_10 PF13237.4 001279707.1_24222001_1 - 1.1e-08 34.9 21.0 3.6e-06 26.9 12.5 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.4 001279707.1_24222001_1 - 1.3e-08 34.7 10.3 2.2e-08 34.0 10.3 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.5 001279707.1_24222001_1 - 2.4e-07 30.4 17.8 0.00033 20.5 5.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_8 PF13183.4 001279707.1_24222001_1 - 4.4e-07 30.1 19.2 0.00021 21.5 11.6 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.5 001279707.1_24222001_1 - 1.1e-06 28.2 12.1 0.0024 17.8 1.9 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.5 001279707.1_24222001_1 - 6e-06 26.2 11.4 0.00029 21.0 2.0 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.4 001279707.1_24222001_1 - 0.00015 22.1 11.6 0.022 15.2 12.7 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.8 001279707.1_24222001_1 - 0.0054 16.8 6.0 0.33 11.1 0.3 2.3 1 1 1 2 2 2 2 c-SKI Smad4 binding domain Fer4_13 PF13370.4 001279707.1_24222001_1 - 0.011 16.2 14.8 0.52 10.8 2.7 2.5 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_18 PF13746.4 001279707.1_24222001_1 - 0.031 14.3 8.5 0.92 9.6 1.4 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.5 001279707.1_24222001_1 - 0.15 13.0 16.4 0.29 12.0 4.1 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain ETF_QO PF05187.11 001279707.1_24222001_1 - 0.21 11.6 5.8 1.1 9.3 0.6 2.4 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_22 PF17179.2 001279707.1_24222001_1 - 0.7 10.6 11.9 2.3 9.0 1.8 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain G_glu_transpept PF01019.19 214030.1_49824001_2 - 3.4e-181 603.4 0.0 3.9e-181 603.2 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase G_glu_transpept PF01019.19 053840.2_45725001_3 - 5.6e-184 612.5 0.0 6.5e-184 612.3 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Mqo PF06039.13 053840.2_45725001_3 - 0.12 10.8 0.0 0.18 10.1 0.0 1.2 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) DJ-1_PfpI PF01965.22 001281639.1_31322001_1 - 1.8e-52 177.3 0.0 2.1e-52 177.2 0.0 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.3 001281639.1_31322001_1 - 0.00011 21.9 0.0 0.0096 15.5 0.0 2.1 1 1 1 2 2 2 2 ThiJ/PfpI family-like GATase_3 PF07685.12 001281639.1_31322001_1 - 0.0074 15.8 0.0 0.015 14.8 0.0 1.4 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain MlrC_C PF07171.10 001281639.1_31322001_1 - 0.075 13.1 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 MlrC C-terminus PID PF00640.21 001353792.1_26228001_3 - 7.5e-48 162.0 0.8 7.5e-48 162.0 0.8 2.0 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) PDZ PF00595.22 001353792.1_26228001_3 - 2.8e-26 91.6 9.9 5.3e-13 49.0 0.4 2.7 3 0 0 3 3 3 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001353792.1_26228001_3 - 3.2e-05 24.0 0.1 0.0027 17.8 0.0 2.4 2 0 0 2 2 2 1 PDZ domain Tristanin_u2 PF16638.3 001353792.1_26228001_3 - 0.037 14.7 1.2 0.15 12.8 1.2 2.0 1 0 0 1 1 1 0 Unstructured region on methyltransferase between zinc-fingers NRho PF16733.3 001353792.1_26228001_3 - 0.13 12.2 0.3 0.36 10.8 0.1 1.8 2 0 0 2 2 2 0 Rhomboid N-terminal domain SSF PF00474.15 214182.1_49825001_3 - 3.5e-172 572.7 24.9 3.5e-172 572.7 24.9 1.7 2 0 0 2 2 2 1 Sodium:solute symporter family LRR_8 PF13855.4 001109637.1_45726001_1 - 4.6e-29 99.8 29.5 4.4e-08 32.6 1.0 4.3 1 1 4 5 5 5 5 Leucine rich repeat LRR_4 PF12799.5 001109637.1_45726001_1 - 9.2e-23 79.7 15.0 2.9e-06 27.4 0.1 5.5 3 2 3 6 6 6 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001109637.1_45726001_1 - 6.2e-06 25.7 8.0 0.0077 15.6 0.7 2.2 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.31 001109637.1_45726001_1 - 0.0068 16.6 12.3 44 5.0 0.0 7.7 7 1 0 7 7 7 0 Leucine Rich Repeat LRR_6 PF13516.4 001109637.1_45726001_1 - 0.065 13.2 19.7 1.5 8.9 0.3 6.5 7 0 0 7 7 7 0 Leucine Rich repeat APP_E2 PF12925.5 001013018.1_39725001_1 - 3e-74 248.7 20.3 5.5e-74 247.9 20.3 1.4 1 0 0 1 1 1 1 E2 domain of amyloid precursor protein APP_N PF02177.14 001013018.1_39725001_1 - 6.1e-44 148.3 0.5 6.1e-44 148.3 0.5 2.4 2 0 0 2 2 2 1 Amyloid A4 N-terminal heparin-binding Beta-APP PF03494.11 001013018.1_39725001_1 - 6.2e-27 93.0 1.7 1.1e-26 92.3 1.7 1.4 1 0 0 1 1 1 1 Beta-amyloid peptide (beta-APP) APP_amyloid PF10515.7 001013018.1_39725001_1 - 9.5e-26 90.0 0.3 6.1e-25 87.4 0.3 2.5 1 0 0 1 1 1 1 beta-amyloid precursor protein C-terminus APP_Cu_bd PF12924.5 001013018.1_39725001_1 - 1.7e-25 89.4 4.7 1.7e-25 89.4 4.7 2.8 3 0 0 3 3 3 1 Copper-binding of amyloid precursor, CuBD Kunitz_BPTI PF00014.21 001013018.1_39725001_1 - 1.1e-19 70.3 6.5 2.3e-19 69.2 6.5 1.6 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Spore_III_AB PF09548.8 001013018.1_39725001_1 - 0.29 11.1 1.9 1 9.3 1.9 1.8 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) PilJ PF13675.4 001013018.1_39725001_1 - 1.4 8.9 7.3 0.43 10.5 2.6 2.5 2 1 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term PID PF00640.21 031780.1_45726001_3 - 1.4e-51 174.1 2.3 2.3e-51 173.4 2.3 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PDZ PF00595.22 031780.1_45726001_3 - 6.6e-28 96.8 5.8 3.4e-13 49.6 0.4 2.6 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 031780.1_45726001_3 - 1.3e-05 25.3 0.1 0.0018 18.4 0.0 2.5 2 0 0 2 2 2 1 PDZ domain NRho PF16733.3 031780.1_45726001_3 - 0.071 13.1 0.2 0.24 11.4 0.1 1.9 2 0 0 2 2 2 0 Rhomboid N-terminal domain FixQ PF05545.9 031780.1_45726001_3 - 5 7.0 4.6 9.5 6.1 4.6 1.5 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ APP_E2 PF12925.5 001195669.1_37927001_2 - 5.5e-74 247.9 20.0 8.8e-74 247.2 20.0 1.3 1 0 0 1 1 1 1 E2 domain of amyloid precursor protein APP_N PF02177.14 001195669.1_37927001_2 - 2.7e-43 146.3 0.5 2.7e-43 146.3 0.5 2.1 2 0 0 2 2 2 1 Amyloid A4 N-terminal heparin-binding Beta-APP PF03494.11 001195669.1_37927001_2 - 9.1e-27 92.5 1.7 1.6e-26 91.7 1.7 1.4 1 0 0 1 1 1 1 Beta-amyloid peptide (beta-APP) APP_Cu_bd PF12924.5 001195669.1_37927001_2 - 2.7e-26 92.0 7.6 2.6e-25 88.8 4.7 2.8 2 0 0 2 2 2 1 Copper-binding of amyloid precursor, CuBD APP_amyloid PF10515.7 001195669.1_37927001_2 - 1.9e-25 89.0 0.3 9.3e-25 86.8 0.3 2.3 1 0 0 1 1 1 1 beta-amyloid precursor protein C-terminus Kunitz_BPTI PF00014.21 001195669.1_37927001_2 - 1.4e-19 69.9 6.5 3.5e-19 68.6 6.5 1.7 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Mod_r PF07200.11 001195669.1_37927001_2 - 0.72 9.8 12.2 0.14 12.2 7.2 2.2 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein PilJ PF13675.4 001195669.1_37927001_2 - 2.3 8.2 6.8 0.4 10.6 1.8 2.3 2 1 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Cyt-b5 PF00173.26 213911.1_49824001_3 - 5.3e-14 52.0 0.0 8.8e-14 51.3 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain WW PF00397.24 001024869.1_45724001_3 - 3.7e-08 33.0 0.1 8.3e-08 31.9 0.1 1.6 1 0 0 1 1 1 1 WW domain TFIIA PF03153.11 001024869.1_45724001_3 - 4.1 7.2 13.3 5.4 6.8 13.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ig_3 PF13927.4 022628.1_45729001_2 - 1.5e-67 224.0 0.3 9.6e-09 35.6 0.0 9.4 9 0 0 9 9 9 9 Immunoglobulin domain C2-set_2 PF08205.10 022628.1_45729001_2 - 4.5e-65 215.6 11.3 6.7e-17 61.2 0.0 7.1 7 0 0 7 7 7 6 CD80-like C2-set immunoglobulin domain I-set PF07679.14 022628.1_45729001_2 - 4.5e-48 161.1 0.0 2.3e-08 33.9 0.0 8.3 9 0 0 9 9 9 7 Immunoglobulin I-set domain Ig_2 PF13895.4 022628.1_45729001_2 - 3.3e-46 155.4 0.0 6.3e-08 32.7 0.0 9.2 8 1 1 9 9 9 7 Immunoglobulin domain ig PF00047.23 022628.1_45729001_2 - 3.3e-37 126.4 0.0 4e-05 23.6 0.0 9.6 9 0 0 9 9 9 7 Immunoglobulin domain V-set PF07686.15 022628.1_45729001_2 - 7.9e-14 51.6 2.1 0.00089 19.3 0.0 9.2 8 4 0 8 8 8 3 Immunoglobulin V-set domain fn3 PF00041.19 022628.1_45729001_2 - 4.5e-11 42.8 0.0 1.2e-10 41.4 0.0 1.8 1 0 0 1 1 1 1 Fibronectin type III domain RNase_H PF00075.22 001286938.1_45723001_1 - 4.2e-45 153.3 0.0 5.8e-45 152.9 0.0 1.2 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.14 001286938.1_45723001_1 - 9.6e-19 67.3 0.9 2e-18 66.3 0.9 1.6 1 0 0 1 1 1 1 Caulimovirus viroplasmin RVT_3 PF13456.4 001286938.1_45723001_1 - 0.0032 17.0 0.0 0.0075 15.8 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase-like UCR_6-4kD PF08997.8 001287109.1_45722001_2 - 1.9e-31 107.6 1.5 2.6e-31 107.2 1.5 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex, 6.4kD protein QCR10 PF09796.7 001287109.1_45722001_2 - 0.41 10.6 2.3 1.2 9.1 2.3 1.7 1 1 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) Lectin_N PF03954.12 001671.4_26224001_2 - 9e-61 203.3 5.1 1.4e-60 202.7 5.1 1.2 1 0 0 1 1 1 1 Hepatic lectin, N-terminal domain Lectin_C PF00059.19 001671.4_26224001_2 - 5.7e-24 84.8 1.0 9.4e-24 84.1 1.0 1.4 1 0 0 1 1 1 1 Lectin C-type domain Tropomyosin_1 PF12718.5 001671.4_26224001_2 - 0.0024 17.9 0.6 0.004 17.1 0.6 1.2 1 0 0 1 1 1 1 Tropomyosin like IFT57 PF10498.7 001671.4_26224001_2 - 0.05 12.5 1.0 0.072 11.9 1.0 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Jnk-SapK_ap_N PF09744.7 001671.4_26224001_2 - 0.18 11.9 1.2 0.34 11.0 1.2 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 MAM PF00629.21 001287618.1_45729001_1 - 1.2e-264 867.0 27.2 2.8e-43 147.4 0.1 9.3 9 0 0 9 9 9 9 MAM domain, meprin/A5/mu Ldl_recept_a PF00057.16 001287618.1_45729001_1 - 6.1e-51 170.2 163.5 1.6e-08 34.5 11.2 11.0 10 0 0 10 10 10 10 Low-density lipoprotein receptor domain class A Pkinase_Tyr PF07714.15 001289495.1_32925001_2 - 9.2e-93 310.1 0.0 1.2e-92 309.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001289495.1_32925001_2 - 3.6e-45 154.2 0.0 5.4e-45 153.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 001289495.1_32925001_2 - 3.1e-23 81.5 1.0 6e-23 80.6 1.0 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 001289495.1_32925001_2 - 2e-11 43.1 0.0 5.3e-11 41.8 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 001289495.1_32925001_2 - 5.1e-09 35.7 0.0 9.2e-09 34.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001289495.1_32925001_2 - 0.0019 17.7 0.0 0.0047 16.4 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain zf-H2C2_2 PF13465.4 001290085.1_26226001_1 - 4.5e-76 248.0 91.1 2.3e-08 34.0 3.0 12.9 12 0 0 12 12 12 12 Zinc-finger double domain zf-C2H2 PF00096.24 001290085.1_26226001_1 - 2.7e-37 125.0 84.5 5e-05 23.4 2.8 12.2 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001290085.1_26226001_1 - 2.9e-33 111.5 81.9 0.0072 16.9 0.3 12.1 11 0 0 11 11 11 10 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001290085.1_26226001_1 - 5.3e-14 51.6 61.1 0.0056 16.5 0.0 11.0 10 0 0 10 10 10 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001290085.1_26226001_1 - 1.4e-08 34.5 56.7 0.024 14.6 2.6 7.7 3 2 7 10 10 10 8 Zinc ribbon domain DUF3268 PF11672.6 001290085.1_26226001_1 - 0.0009 19.4 40.6 0.11 12.7 2.8 5.7 4 1 2 6 6 6 4 zinc-finger-containing domain zf-C2H2_jaz PF12171.6 001290085.1_26226001_1 - 0.071 13.3 54.4 1.6 9.0 0.3 10.2 10 0 0 10 10 10 0 Zinc-finger double-stranded RNA-binding HTH_18 PF12833.5 001290085.1_26226001_1 - 0.09 12.9 0.5 0.7 10.1 0.0 2.8 3 0 0 3 3 3 0 Helix-turn-helix domain XPA_N PF01286.16 001290085.1_26226001_1 - 0.4 10.6 54.5 1.4 8.9 0.1 10.5 10 0 0 10 10 10 0 XPA protein N-terminal KRAB PF01352.25 001290085.1_26226001_2 - 1.5e-22 78.9 0.3 3.3e-22 77.8 0.3 1.6 1 0 0 1 1 1 1 KRAB box AlbA_2 PF04326.12 001195790.1_26224001_1 - 4.3e-15 56.0 2.3 1.5e-10 41.3 0.1 3.1 2 1 1 3 3 3 2 Putative DNA-binding domain B3R PF17057.3 001195790.1_26224001_1 - 1.7e-06 28.1 0.0 3.4e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Poxviridae B3 protein LRR_9 PF14580.4 001199018.2_26227001_2 - 1.1e-22 80.2 15.7 9.1e-14 51.2 2.8 3.5 2 1 1 3 3 3 3 Leucine-rich repeat LRR_4 PF12799.5 001199018.2_26227001_2 - 6.7e-21 73.8 34.9 2.2e-07 30.9 5.6 5.6 2 1 3 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001199018.2_26227001_2 - 1.2e-12 47.2 55.7 1.9e-07 30.6 8.4 5.3 4 1 5 9 9 9 6 Leucine rich repeat DUF2322 PF10084.7 001199018.2_26227001_2 - 0.43 10.6 1.6 13 5.8 0.2 3.2 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2322) APG6 PF04111.10 001286619.1_26225001_2 - 0.017 14.4 8.2 0.022 14.0 8.2 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Seryl_tRNA_N PF02403.20 001286619.1_26225001_2 - 0.2 11.7 9.2 0.38 10.9 9.2 1.3 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Spc24 PF08286.9 001286619.1_26225001_2 - 0.32 11.1 4.9 0.59 10.3 4.9 1.4 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 BRE1 PF08647.9 001286619.1_26225001_2 - 0.32 11.0 8.5 0.56 10.2 8.5 1.3 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase Lysyl_oxidase PF01186.15 001164311.1_32929001_1 - 4.4e-98 326.8 3.8 6.8e-98 326.2 3.8 1.3 1 0 0 1 1 1 1 Lysyl oxidase SRCR PF00530.16 001164311.1_32929001_1 - 1.6e-93 307.6 31.7 1.6e-28 99.0 2.3 4.7 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.4 001164311.1_32929001_1 - 3.9e-20 72.0 15.4 0.00021 21.6 0.9 4.6 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain CARDB PF07705.9 001164311.1_32929001_1 - 0.21 11.7 0.1 0.46 10.6 0.1 1.5 1 0 0 1 1 1 0 CARDB YecR PF13992.4 001164311.1_32929001_1 - 2.7 8.2 7.4 0.96 9.7 0.1 3.6 5 0 0 5 5 5 0 YecR-like lipoprotein Lsm_interact PF05391.9 001164311.1_32929001_3 - 0.2 11.1 0.2 0.4 10.1 0.2 1.5 1 0 0 1 1 1 0 Lsm interaction motif CD34_antigen PF06365.10 001284320.1_26228001_2 - 0.15 11.5 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family MCM PF00493.21 001191805.2_45726001_2 - 1.2e-126 422.2 1.8 2.6e-126 421.1 1.8 1.6 1 1 0 1 1 1 1 MCM2/3/5 family MCM_OB PF17207.1 001191805.2_45726001_2 - 2.2e-34 117.9 0.9 6.7e-34 116.3 0.5 2.1 2 0 0 2 2 2 1 MCM OB domain MCM_N PF14551.4 001191805.2_45726001_2 - 1.8e-10 41.2 1.0 1.8e-10 41.2 1.0 2.2 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.19 001191805.2_45726001_2 - 1.7e-07 30.7 0.0 8.2e-07 28.5 0.0 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.9 001191805.2_45726001_2 - 0.002 17.9 0.0 0.0084 15.8 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.12 001191805.2_45726001_2 - 0.0046 16.8 0.1 0.036 13.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.24 001191805.2_45726001_2 - 0.034 13.7 0.1 0.14 11.7 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF908 PF06012.10 001191805.2_45726001_2 - 0.14 11.4 11.7 0.22 10.7 11.7 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) ADP_ribosyl_GH PF03747.12 199162.2_26224001_3 - 2e-39 135.9 0.0 2.7e-39 135.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase dsrm PF00035.24 003690.4_26224001_1 - 1.5e-31 108.7 0.3 4.6e-13 49.5 0.0 3.4 3 0 0 3 3 3 3 Double-stranded RNA binding motif Staufen_C PF16482.3 003690.4_26224001_1 - 6.4e-09 35.8 0.4 6.8e-07 29.3 0.0 3.1 2 1 1 3 3 3 1 Staufen C-terminal domain DND1_DSRM PF14709.5 003690.4_26224001_1 - 2.8e-07 30.6 1.6 0.0064 16.6 0.2 3.9 3 1 0 3 3 3 2 double strand RNA binding domain from DEAD END PROTEIN 1 APO_RNA-bind PF05634.9 003690.4_26224001_1 - 0.00094 18.5 0.0 0.0014 17.9 0.0 1.2 1 0 0 1 1 1 1 APO RNA-binding Vinculin PF01044.17 001286974.1_26226001_3 - 7.9e-57 193.1 23.6 1.3e-38 132.8 9.4 3.0 3 0 0 3 3 3 3 Vinculin family Focal_AT PF03623.11 001286974.1_26226001_3 - 9 6.1 15.7 0.26 11.1 2.6 3.6 3 1 0 3 3 3 0 Focal adhesion targeting region Homeobox PF00046.27 001040416.1_29624001_2 - 7.3e-21 73.6 4.6 1.2e-20 73.0 4.6 1.3 1 0 0 1 1 1 1 Homeobox domain DUF2457 PF10446.7 001040416.1_29624001_2 - 4.1 6.3 7.8 6.6 5.6 7.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) HSF_DNA-bind PF00447.15 001080439.2_26229001_2 - 4.6e-17 62.3 0.0 8.3e-17 61.4 0.0 1.4 1 0 0 1 1 1 1 HSF-type DNA-binding MFS_1 PF07690.14 005835.3_26225001_3 - 2.1e-39 135.4 22.3 2.8e-39 134.9 22.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Arm PF00514.21 001287020.1_45726001_1 - 1.5e-42 142.2 14.0 1.6e-06 27.8 0.1 10.6 11 0 0 11 11 11 6 Armadillo/beta-catenin-like repeat EDR1 PF14381.4 001287020.1_45726001_1 - 1.4e-38 132.5 0.0 6.3e-38 130.4 0.0 2.2 1 1 0 1 1 1 1 Ethylene-responsive protein kinase Le-CTR1 HEAT_2 PF13646.4 001287020.1_45726001_1 - 2.9e-27 94.7 7.7 1.5e-06 28.4 0.6 6.4 2 1 3 6 6 6 6 HEAT repeats HEAT PF02985.20 001287020.1_45726001_1 - 5e-22 75.9 8.3 0.00026 20.8 0.0 9.5 9 0 0 9 9 9 5 HEAT repeat HEAT_EZ PF13513.4 001287020.1_45726001_1 - 4.1e-20 71.7 1.2 0.0005 20.3 0.0 8.2 8 1 1 9 9 9 4 HEAT-like repeat V-ATPase_H_C PF11698.6 001287020.1_45726001_1 - 4.5e-11 42.7 8.6 0.075 13.0 0.1 6.1 2 1 4 6 6 6 4 V-ATPase subunit H V-ATPase_H_N PF03224.12 001287020.1_45726001_1 - 6.7e-09 35.3 2.3 0.0034 16.6 0.0 3.4 1 1 2 3 3 3 3 V-ATPase subunit H Cnd1 PF12717.5 001287020.1_45726001_1 - 9.5e-09 35.3 15.9 0.0013 18.6 0.2 5.5 1 1 4 5 5 5 3 non-SMC mitotic condensation complex subunit 1 UNC45-central PF11701.6 001287020.1_45726001_1 - 2.2e-08 34.1 9.4 8.9e-05 22.4 0.3 4.3 3 2 1 4 4 4 3 Myosin-binding striated muscle assembly central CLASP_N PF12348.6 001287020.1_45726001_1 - 0.00012 21.6 5.9 0.18 11.2 0.2 3.7 2 1 1 3 3 3 2 CLASP N terminal Vac14_Fab1_bd PF12755.5 001287020.1_45726001_1 - 0.00063 20.1 0.3 4.8 7.7 0.0 4.8 5 0 0 5 5 5 1 Vacuolar 14 Fab1-binding region Arm_2 PF04826.11 001287020.1_45726001_1 - 0.003 16.9 12.6 0.047 13.0 1.7 4.8 1 1 4 5 5 5 1 Armadillo-like Mo25 PF08569.9 001287020.1_45726001_1 - 0.0068 15.7 3.7 0.0078 15.5 0.3 2.3 1 1 1 2 2 2 1 Mo25-like HEAT_PBS PF03130.14 001287020.1_45726001_1 - 0.038 14.5 0.6 0.038 14.5 0.6 6.0 7 1 0 7 7 6 0 PBS lyase HEAT-like repeat Arm_3 PF16186.3 001287020.1_45726001_1 - 0.14 11.6 1.5 3.9 7.0 0.0 4.0 5 1 0 5 5 5 0 Atypical Arm repeat RasGEF_N_2 PF14663.4 001287020.1_45726001_1 - 0.22 11.7 8.6 7.4 6.8 0.1 5.5 4 2 2 6 6 6 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain ALF PF03752.11 001287020.1_45726001_1 - 2.2 8.2 4.1 2 8.3 1.5 2.3 2 0 0 2 2 2 0 Short repeats of unknown function HLH PF00010.24 001107958.2_45729001_2 - 2.7e-15 55.9 0.2 4.4e-15 55.3 0.2 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain COE1_HLH PF16423.3 001107958.2_45729001_2 - 0.098 12.2 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Transcription factor COE1 helix-loop-helix domain OB_NTP_bind PF07717.14 007839.3_32927001_2 - 5.2e-27 94.1 0.1 1.1e-26 93.0 0.1 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.21 007839.3_32927001_2 - 3.3e-24 85.1 0.2 3.3e-24 85.1 0.2 2.2 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.29 007839.3_32927001_2 - 1.9e-12 47.4 0.0 4.1e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.27 007839.3_32927001_2 - 1.5e-06 28.0 0.0 3.3e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.4 007839.3_32927001_2 - 0.00011 22.5 0.0 0.00023 21.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.4 007839.3_32927001_2 - 0.00066 19.8 0.1 0.0038 17.4 0.1 2.2 1 1 0 1 1 1 1 AAA domain SRP54 PF00448.20 007839.3_32927001_2 - 0.0035 16.9 0.0 0.0082 15.7 0.0 1.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain ResIII PF04851.13 007839.3_32927001_2 - 0.0044 16.9 0.0 0.62 9.9 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.4 007839.3_32927001_2 - 0.0072 15.9 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.4 007839.3_32927001_2 - 0.023 14.2 0.0 0.05 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain Flavi_DEAD PF07652.12 007839.3_32927001_2 - 0.024 14.5 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_29 PF13555.4 007839.3_32927001_2 - 0.027 14.1 0.0 0.06 12.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Atrophin-1 PF03154.13 007839.3_32927001_2 - 0.089 10.9 9.6 0.13 10.4 9.6 1.2 1 0 0 1 1 1 0 Atrophin-1 family DUF1777 PF08648.10 007839.3_32927001_2 - 0.16 12.1 19.3 0.26 11.4 19.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) AAA_23 PF13476.4 007839.3_32927001_2 - 0.23 11.8 1.2 0.53 10.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain Lge1 PF11488.6 175363.4_32928001_1 - 1e-16 61.1 0.4 1e-16 61.1 0.4 1.9 2 0 0 2 2 2 1 Transcriptional regulatory protein LGE1 Calponin PF00402.16 001839.4_26225001_3 - 2.3e-44 148.5 16.8 2.5e-16 58.8 1.8 3.9 3 0 0 3 3 3 3 Calponin family repeat CH PF00307.29 001839.4_26225001_3 - 4.3e-22 78.2 0.0 6.5e-22 77.6 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain FAM222A PF15258.4 001288638.1_26229001_1 - 8.9e-225 747.6 29.8 1.1e-224 747.3 29.8 1.1 1 0 0 1 1 1 1 Protein family of FAM222A DUF2981 PF11200.6 001288638.1_26229001_1 - 5.7 5.9 8.1 2.4 7.1 4.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2981) Cystatin PF00031.19 001323.3_26222001_1 - 2.6e-18 65.9 0.0 3.4e-18 65.6 0.0 1.1 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.3 001323.3_26222001_1 - 5.4e-05 23.3 0.0 9.4e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor CD24 PF14984.4 001032285.1_45724001_1 - 0.016 15.3 4.1 0.016 15.3 4.1 3.2 4 0 0 4 4 4 0 CD24 protein CD225 PF04505.10 001032285.1_45724001_2 - 6.3e-21 74.1 1.4 1.1e-20 73.3 1.4 1.4 1 0 0 1 1 1 1 Interferon-induced transmembrane protein zf-H2C2_2 PF13465.4 001289171.1_26226001_1 - 5.3e-132 424.8 152.2 8.2e-09 35.4 0.3 20.8 20 1 1 21 21 20 20 Zinc-finger double domain zf-C2H2 PF00096.24 001289171.1_26226001_1 - 1.1e-89 290.0 136.6 2.1e-06 27.8 0.2 19.8 19 0 0 19 19 19 18 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001289171.1_26226001_1 - 1.7e-45 149.5 141.6 0.004 17.7 0.3 20.2 21 0 0 21 21 19 17 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001289171.1_26226001_1 - 3e-22 78.3 71.1 0.26 11.5 0.1 17.8 18 0 0 18 18 18 9 Zinc-finger double-stranded RNA-binding KRAB PF01352.25 001289171.1_26226001_1 - 4.7e-20 70.9 0.3 8e-20 70.1 0.3 1.4 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 001289171.1_26226001_1 - 1.5e-12 47.3 100.1 0.029 14.4 2.2 13.2 4 2 13 17 17 17 13 Zinc ribbon domain zf-C2H2_6 PF13912.4 001289171.1_26226001_1 - 3.7e-12 45.8 118.6 0.017 14.9 0.5 19.6 20 0 0 20 20 20 10 C2H2-type zinc finger XPA_N PF01286.16 001289171.1_26226001_1 - 3.4e-07 30.0 86.1 1.3 9.0 0.0 17.8 18 0 0 18 18 18 5 XPA protein N-terminal zinc_ribbon_15 PF17032.3 001289171.1_26226001_1 - 4.4e-06 27.2 66.6 1.3 9.7 0.4 9.6 3 2 8 11 11 11 6 zinc-ribbon family zf-met PF12874.5 001289171.1_26226001_1 - 1.8e-05 24.8 114.5 0.034 14.4 0.3 17.4 18 0 0 18 18 18 7 Zinc-finger of C2H2 type Herpes_ORF11 PF04797.11 001289171.1_26226001_1 - 0.0037 16.0 0.0 4.1 6.0 0.0 3.4 2 1 2 4 4 4 1 Herpesvirus dUTPase protein DUF3268 PF11672.6 001289171.1_26226001_1 - 0.0042 17.3 59.5 0.22 11.7 1.0 8.7 3 2 2 9 9 9 5 zinc-finger-containing domain C1_4 PF07975.10 001289171.1_26226001_1 - 0.031 14.4 77.9 1 9.5 2.2 12.8 1 1 10 14 14 13 0 TFIIH C1-like domain CpXC PF14353.4 001289171.1_26226001_1 - 0.07 13.0 60.8 4.5 7.2 0.2 15.1 5 3 6 13 13 13 0 CpXC protein BolA PF01722.16 001289171.1_26226001_1 - 0.49 10.6 28.1 2.5 8.3 0.4 7.2 5 3 1 6 6 6 0 BolA-like protein HypA PF01155.17 001289171.1_26226001_1 - 2.3 8.1 63.6 1.6 8.6 1.1 9.8 1 1 9 10 10 10 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA GST_C PF00043.23 001159739.2_45723001_1 - 5.1e-19 68.2 0.0 7.9e-19 67.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 001159739.2_45723001_1 - 3.1e-18 65.7 0.0 5e-18 65.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.18 001159739.2_45723001_1 - 4.7e-17 62.0 0.0 9.2e-17 61.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain FMO-like PF00743.17 001009008.2_39728001_3 - 3.6e-295 979.3 0.1 4.3e-295 979.0 0.1 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.4 001009008.2_39728001_3 - 2.9e-17 62.8 0.0 7.1e-11 41.8 0.0 3.0 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.4 001009008.2_39728001_3 - 1.5e-11 43.9 0.0 4.9e-08 32.4 0.0 3.0 2 1 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.12 001009008.2_39728001_3 - 3.4e-09 36.2 0.0 1.7e-08 34.0 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.4 001009008.2_39728001_3 - 0.00048 20.2 0.0 0.0016 18.5 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.4 001009008.2_39728001_3 - 0.0019 18.1 0.0 4.2 7.2 0.0 3.3 2 1 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.22 001009008.2_39728001_3 - 0.002 17.7 0.3 0.23 10.9 0.0 2.9 3 1 0 3 3 3 1 FAD dependent oxidoreductase IlvN PF07991.10 001009008.2_39728001_3 - 0.0078 15.7 0.0 0.13 11.7 0.0 2.2 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Pyr_redox PF00070.25 001009008.2_39728001_3 - 0.0091 16.4 0.3 0.78 10.2 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.17 001009008.2_39728001_3 - 0.014 14.6 0.0 0.3 10.3 0.0 2.1 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.18 001009008.2_39728001_3 - 0.016 15.1 0.0 1 9.3 0.0 2.5 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DUF3146 PF11344.6 001009008.2_39728001_3 - 0.098 12.2 0.1 0.24 10.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3146) TM231 PF10149.7 001271031.1_45726001_3 - 1.6e-124 415.0 0.8 2e-124 414.7 0.8 1.1 1 0 0 1 1 1 1 Transmembrane protein 231 KRAB PF01352.25 001304337.1_26222001_3 - 1.6e-24 85.1 1.0 2.7e-24 84.4 1.0 1.4 1 0 0 1 1 1 1 KRAB box Lysyl_oxidase PF01186.15 001107866.2_45726001_3 - 7.3e-101 335.9 5.2 1.5e-100 334.9 5.2 1.5 1 0 0 1 1 1 1 Lysyl oxidase SRCR PF00530.16 001107866.2_45726001_3 - 6.3e-97 318.5 31.5 1.6e-29 102.2 3.1 5.3 5 0 0 5 5 5 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.4 001107866.2_45726001_3 - 5.2e-17 62.0 16.7 0.0022 18.3 0.1 4.7 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain CARDB PF07705.9 001107866.2_45726001_3 - 0.046 13.8 0.1 0.13 12.4 0.1 1.7 1 0 0 1 1 1 0 CARDB Hepsin-SRCR PF09272.8 001107866.2_45726001_3 - 0.14 12.3 3.0 1.8 8.8 0.1 3.2 3 0 0 3 3 3 0 Hepsin, SRCR Trypsin PF00089.24 001106863.2_45723001_1 - 6.9e-69 231.9 1.9 8.4e-69 231.6 1.9 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 001106863.2_45723001_1 - 3.9e-07 30.3 1.2 8.9e-07 29.2 1.2 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 001106863.2_45723001_1 - 1.5e-05 25.8 0.0 2.9e-05 24.8 0.0 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain Npa1 PF11707.6 001191661.1_45729001_1 - 2.3e-81 273.6 0.4 1.6e-80 270.8 0.4 2.6 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.3 001191661.1_45729001_1 - 1.4e-56 191.1 0.7 1.4e-56 191.1 0.7 2.8 3 0 0 3 3 3 1 Nucleolar pre-ribosomal-associated protein 1 Ribophorin_I PF04597.12 013067.2_45725001_3 - 2.3e-145 485.0 3.4 2.9e-145 484.7 3.4 1.1 1 0 0 1 1 1 1 Ribophorin I CtIP_N PF10482.7 013067.2_45725001_3 - 0.035 14.1 0.6 0.07 13.1 0.6 1.5 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain FliD_C PF07195.10 013067.2_45725001_3 - 0.048 12.9 0.9 0.12 11.7 0.2 1.8 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus DNA_repr_REX1B PF14966.4 013067.2_45725001_3 - 0.053 14.0 0.6 0.11 13.0 0.6 1.5 1 0 0 1 1 1 0 DNA repair REX1-B GDPD PF03009.15 001305187.1_45723001_1 - 8.1e-28 97.7 0.1 7.3e-22 78.2 0.0 2.3 2 1 0 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.4 001305187.1_45723001_1 - 0.0023 18.3 0.0 0.005 17.2 0.0 1.6 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family tRNA-synt_1_2 PF13603.4 001305187.1_45723001_1 - 0.13 11.6 0.0 0.3 10.4 0.0 1.5 2 0 0 2 2 2 0 Leucyl-tRNA synthetase, Domain 2 zf-CXXC PF02008.18 001317209.1_26225001_2 - 5.9e-07 29.3 24.2 5.9e-07 29.3 24.2 3.0 3 0 0 3 3 3 1 CXXC zinc finger domain Myosin_tail_1 PF01576.17 013194.2_45729001_1 - 0 1669.1 310.8 0 1668.8 310.8 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.19 013194.2_45729001_1 - 0 1022.0 0.6 0 1022.0 0.6 3.7 4 1 1 5 5 5 1 Myosin head (motor domain) Myosin_N PF02736.17 013194.2_45729001_1 - 6.8e-10 38.5 2.4 1.4e-09 37.5 2.4 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain IQ PF00612.25 013194.2_45729001_1 - 0.00046 19.6 0.1 0.0014 18.1 0.1 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif CC2-LZ PF16516.3 013194.2_45729001_1 - 0.00078 19.6 20.6 0.00078 19.6 20.6 17.0 3 2 10 15 15 15 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Reo_sigmaC PF04582.10 013194.2_45729001_1 - 0.0013 18.1 2.4 0.0013 18.1 2.4 8.8 2 2 3 8 8 8 5 Reovirus sigma C capsid protein ADIP PF11559.6 013194.2_45729001_1 - 0.0022 17.9 20.1 0.0022 17.9 20.1 14.9 2 2 13 15 15 15 2 Afadin- and alpha -actinin-Binding AAA_22 PF13401.4 013194.2_45729001_1 - 0.12 12.5 0.0 0.12 12.5 0.0 6.0 6 2 0 6 6 6 0 AAA domain Abi_HHR PF07815.12 001305447.1_45727001_1 - 0.15 12.1 0.0 0.28 11.2 0.0 1.3 1 0 0 1 1 1 0 Abl-interactor HHR BAAT_C PF08840.9 001305285.1_45724001_3 - 1.7e-74 250.2 0.0 2.1e-74 249.9 0.0 1.1 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Bile_Hydr_Trans PF04775.12 001305285.1_45724001_3 - 1e-40 138.5 0.0 1.5e-40 138.0 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA thioester hydrolase/BAAT N-terminal region DLH PF01738.16 001305285.1_45724001_3 - 4.3e-05 23.0 0.0 0.013 14.9 0.0 2.3 2 0 0 2 2 2 2 Dienelactone hydrolase family Peptidase_S9 PF00326.19 001305285.1_45724001_3 - 0.00031 20.2 0.0 0.003 16.9 0.0 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family FSH1 PF03959.11 001305285.1_45724001_3 - 0.0022 17.6 0.0 0.0035 16.9 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.18 001305285.1_45724001_3 - 0.034 13.7 0.1 0.24 10.9 0.0 2.3 3 0 0 3 3 3 0 alpha/beta hydrolase fold Abhydrolase_3 PF07859.11 001305285.1_45724001_3 - 0.035 13.8 0.0 0.057 13.1 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold YAF2_RYBP PF17219.1 001134871.2_45725001_3 - 1.9e-18 65.5 0.1 4.2e-18 64.4 0.1 1.6 1 0 0 1 1 1 1 Yaf2/RYBP C-terminal binding motif zf-RanBP PF00641.16 001134871.2_45725001_3 - 4.1e-08 32.3 2.0 1e-07 31.0 2.0 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Ald_Xan_dh_C2 PF02738.16 001308400.1_29529001_3 - 2.6e-188 626.8 0.0 3.3e-188 626.4 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 001308400.1_29529001_3 - 3.2e-46 157.1 0.0 7.4e-46 155.9 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.20 001308400.1_29529001_3 - 4.6e-31 107.3 0.5 7.8e-31 106.6 0.5 1.4 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.18 001308400.1_29529001_3 - 9.3e-31 105.5 0.2 2e-30 104.4 0.2 1.6 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.15 001308400.1_29529001_3 - 1.4e-27 95.8 0.0 4.2e-26 91.0 0.0 2.7 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.25 001308400.1_29529001_3 - 2.8e-05 23.8 0.6 9.8e-05 22.1 0.0 2.3 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain DHODB_Fe-S_bind PF10418.7 001308400.1_29529001_3 - 0.014 15.1 1.2 0.042 13.5 1.2 1.8 1 0 0 1 1 1 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B Homeobox PF00046.27 001310580.1_31323001_1 - 2.8e-21 75.0 6.1 4.4e-21 74.3 6.1 1.3 1 0 0 1 1 1 1 Homeobox domain Casein PF00363.16 017120.3_45723001_2 - 1.9e-17 63.5 16.9 1.9e-17 63.5 16.9 2.2 2 1 0 2 2 2 1 Casein Orn_Arg_deC_N PF02784.14 001014261.3_45724001_1 - 3.9e-70 236.0 0.0 4.9e-70 235.6 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001014261.3_45724001_1 - 9.6e-19 67.4 0.0 1.8e-18 66.5 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.22 001014261.3_45724001_1 - 0.0003 20.1 0.0 0.00061 19.2 0.0 1.4 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel MTS PF05175.12 182749.4_26222001_2 - 6.6e-06 25.6 0.0 3.9e-05 23.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_25 PF13649.4 182749.4_26222001_2 - 0.003 18.1 0.0 0.0055 17.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.11 182749.4_26222001_2 - 0.0035 16.6 0.1 0.008 15.5 0.1 1.4 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.17 182749.4_26222001_2 - 0.0065 16.1 0.0 0.0093 15.6 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.4 182749.4_26222001_2 - 0.0083 15.8 0.0 0.082 12.6 0.0 2.0 1 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.10 182749.4_26222001_2 - 0.018 15.6 0.0 0.032 14.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.7 182749.4_26222001_2 - 0.047 13.3 0.0 0.069 12.7 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase DUF938 PF06080.10 182749.4_26222001_2 - 0.15 11.7 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) RRM_1 PF00076.20 001191859.1_45728001_1 - 0.0083 15.8 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001191859.1_45728001_1 - 0.087 12.6 0.0 0.36 10.6 0.0 2.0 2 0 0 2 2 2 0 Occluded RNA-recognition motif RRM_3 PF08777.9 001191859.1_45728001_1 - 1.9 8.5 0.0 1.9 8.5 0.0 3.5 3 0 0 3 3 3 0 RNA binding motif Pkinase PF00069.23 001191624.1_45729001_1 - 1.2e-38 132.8 0.0 2.6e-38 131.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001191624.1_45729001_1 - 1.9e-37 128.9 0.0 3.9e-37 127.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase LRR_8 PF13855.4 001191624.1_45729001_1 - 4.6e-26 90.2 26.6 4.2e-06 26.3 0.1 5.9 5 0 0 5 5 5 5 Leucine rich repeat COR PF16095.3 001191624.1_45729001_1 - 1.1e-23 83.9 0.1 2e-23 83.1 0.1 1.4 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Roc PF08477.11 001191624.1_45729001_1 - 1.2e-22 80.3 0.0 4.2e-22 78.5 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase LRR_4 PF12799.5 001191624.1_45729001_1 - 3.7e-21 74.7 34.8 7.4e-06 26.1 0.2 7.2 6 2 2 8 8 7 6 Leucine Rich repeats (2 copies) Ank_2 PF12796.5 001191624.1_45729001_1 - 1.1e-11 45.1 0.0 0.00019 21.8 0.0 3.0 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Arf PF00025.19 001191624.1_45729001_1 - 4.8e-07 29.3 0.1 1.3e-06 27.8 0.0 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family Ras PF00071.20 001191624.1_45729001_1 - 2.6e-06 27.0 0.0 5e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Ras family Ank_3 PF13606.4 001191624.1_45729001_1 - 3.7e-06 26.7 1.2 0.74 10.4 0.0 4.8 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.4 001191624.1_45729001_1 - 4.5e-06 27.0 0.1 0.012 16.1 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.4 001191624.1_45729001_1 - 8.7e-06 25.8 3.5 0.36 11.2 0.1 4.8 1 1 2 4 4 4 1 Ankyrin repeats (many copies) Ank PF00023.28 001191624.1_45729001_1 - 1.7e-05 24.9 1.6 0.043 14.2 0.1 3.9 3 0 0 3 3 3 1 Ankyrin repeat LRR_1 PF00560.31 001191624.1_45729001_1 - 0.00033 20.6 30.8 4 8.2 0.6 9.6 8 0 0 8 8 8 1 Leucine Rich Repeat Gtr1_RagA PF04670.10 001191624.1_45729001_1 - 0.0075 15.5 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001191624.1_45729001_1 - 0.023 14.7 0.0 0.048 13.6 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase LRR_6 PF13516.4 001191624.1_45729001_1 - 0.081 12.9 24.7 0.72 9.9 0.2 7.5 7 0 0 7 7 7 0 Leucine Rich repeat TniB PF05621.9 001191624.1_45729001_1 - 0.15 11.1 0.2 2.2 7.3 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein LRR_9 PF14580.4 001191624.1_45729001_1 - 2.6 7.4 6.7 0.32 10.3 0.3 2.6 4 0 0 4 4 4 0 Leucine-rich repeat PTB PF08416.11 001191810.1_45729001_1 - 9.3e-38 129.2 0.0 2.5e-37 127.8 0.0 1.7 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PTEN_C2 PF10409.7 001191810.1_45729001_1 - 3.9e-33 113.9 0.0 7.6e-33 113.0 0.0 1.5 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein SH2 PF00017.22 001191810.1_45729001_1 - 2.7e-09 36.8 0.0 6.8e-09 35.5 0.0 1.7 1 0 0 1 1 1 1 SH2 domain C1_1 PF00130.20 001191810.1_45729001_1 - 4.4e-05 23.1 13.8 9.3e-05 22.1 13.8 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Spt20 PF12090.6 001191810.1_45729001_1 - 0.65 9.4 16.5 1.2 8.5 16.5 1.3 1 0 0 1 1 1 0 Spt20 family Prok-RING_1 PF14446.4 001191810.1_45729001_1 - 4.9 7.0 11.3 12 5.8 11.3 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 C1_2 PF03107.14 001191810.1_45729001_1 - 5.3 7.3 12.6 2.4 8.4 9.5 2.1 2 0 0 2 2 2 0 C1 domain IMUP PF15761.3 001191810.1_45729001_2 - 7.7 7.1 12.7 17 6.0 12.7 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein Cyclin_N PF00134.21 001310564.1_31324001_3 - 6.3e-43 145.5 1.1 9.2e-42 141.7 0.4 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 001310564.1_31324001_3 - 4.9e-36 123.3 0.2 1.1e-35 122.2 0.2 1.6 1 0 0 1 1 1 1 Cyclin, C-terminal domain G-gamma PF00631.20 001135777.1_45721001_3 - 6.3e-19 67.6 0.2 8.8e-19 67.2 0.2 1.2 1 0 0 1 1 1 1 GGL domain DUF1725 PF08333.9 001321007.1_26229001_1 - 0.22 11.1 5.0 0.055 13.0 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1725) DNA_methylase PF00145.15 001321007.1_26229001_2 - 1.4e-29 103.4 0.0 1.9e-29 102.9 0.0 1.1 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase DNA_methylase PF00145.15 001321007.1_26229001_3 - 0.003 16.8 0.0 0.0042 16.4 0.0 1.1 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase R3H PF01424.20 001136108.2_26224001_1 - 2.6e-16 59.2 0.2 6.7e-16 57.9 0.1 1.8 2 0 0 2 2 2 1 R3H domain NCBP3 PF10309.7 001136108.2_26224001_1 - 7e-05 22.5 0.0 0.00013 21.6 0.0 1.4 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 MFS_1 PF07690.14 001191994.1_45724001_1 - 4.2e-43 147.5 22.4 5.4e-38 130.7 12.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.18 001191994.1_45724001_1 - 1.9e-05 23.1 3.1 0.00026 19.3 0.1 3.1 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.5 001191994.1_45724001_1 - 0.0025 16.6 9.0 0.0025 16.6 9.0 2.5 2 1 0 2 2 2 1 MFS_1 like family Sugar_tr PF00083.22 001191994.1_45724001_1 - 0.0085 14.9 20.2 0.23 10.1 5.9 2.5 2 0 0 2 2 2 2 Sugar (and other) transporter BTB PF00651.29 001304352.1_45729001_2 - 2.5e-14 53.3 0.0 6.1e-14 52.1 0.0 1.6 1 1 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 001304352.1_45729001_2 - 3.8e-14 52.1 34.8 0.025 14.9 1.9 6.7 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001304352.1_45729001_2 - 7e-08 32.5 39.1 0.47 11.3 0.7 6.7 6 0 0 6 6 6 5 C2H2-type zinc finger zf-H2C2_2 PF13465.4 001304352.1_45729001_2 - 1.2e-05 25.4 34.7 0.01 16.2 0.4 6.7 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2_jaz PF12171.6 001304352.1_45729001_2 - 0.00084 19.5 8.7 0.13 12.5 0.5 4.5 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.4 001304352.1_45729001_2 - 0.0023 17.7 5.1 0.0023 17.7 5.1 3.0 4 0 0 4 4 4 1 zinc-finger of a C2HC-type zf-met PF12874.5 001304352.1_45729001_2 - 0.68 10.3 11.3 16 5.9 0.7 3.7 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-Di19 PF05605.10 001304352.1_45729001_2 - 1.5 9.0 17.1 0.58 10.4 0.5 3.8 4 0 0 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding BSP_II PF05432.9 001304352.1_45729001_2 - 4.5 6.8 12.0 0.75 9.3 4.8 2.4 3 0 0 3 3 3 0 Bone sialoprotein II (BSP-II) CENP-B_dimeris PF09026.8 001304352.1_45729001_2 - 6.3 7.1 8.1 11 6.4 8.1 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain zf-H2C2_2 PF13465.4 001322133.1_26229001_2 - 4.5e-146 469.3 147.8 4.4e-08 33.1 1.0 21.9 21 0 0 21 21 21 21 Zinc-finger double domain zf-C2H2 PF00096.24 001322133.1_26229001_2 - 1.4e-115 371.6 157.2 8.2e-07 29.0 1.0 20.6 20 0 0 20 20 20 20 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001322133.1_26229001_2 - 1.1e-53 175.0 145.7 0.0029 18.2 0.4 20.8 20 0 0 20 20 20 20 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001322133.1_26229001_2 - 1.2e-31 107.9 136.1 0.0099 15.7 0.7 22.2 20 3 0 20 20 20 17 C2H2-type zinc finger KRAB PF01352.25 001322133.1_26229001_2 - 1.6e-25 88.4 0.1 2.8e-25 87.6 0.1 1.4 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 001322133.1_26229001_2 - 1.3e-24 85.9 101.5 0.028 14.4 2.7 16.5 4 3 15 20 20 20 18 Zinc ribbon domain zf-C2H2_11 PF16622.3 001322133.1_26229001_2 - 7.9e-21 73.4 84.1 0.44 10.2 0.1 20.1 20 0 0 20 20 20 11 zinc-finger C2H2-type XPA_N PF01286.16 001322133.1_26229001_2 - 1.1e-16 60.4 61.2 9.7 6.2 0.0 20.0 20 0 0 20 20 20 2 XPA protein N-terminal C1_1 PF00130.20 001322133.1_26229001_2 - 6.5e-13 48.2 70.9 0.17 11.6 0.8 14.0 1 1 17 18 18 18 14 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc_ribbon_15 PF17032.3 001322133.1_26229001_2 - 7.9e-09 36.0 83.1 0.39 11.4 0.6 10.8 1 1 13 15 15 15 14 zinc-ribbon family C1_4 PF07975.10 001322133.1_26229001_2 - 8e-06 25.9 84.2 0.037 14.1 0.9 12.7 3 2 8 14 14 14 6 TFIIH C1-like domain HypA PF01155.17 001322133.1_26229001_2 - 3.2e-05 23.7 71.4 5.6 6.9 1.4 10.9 1 1 10 11 11 11 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_jaz PF12171.6 001322133.1_26229001_2 - 0.029 14.5 86.5 4.4 7.6 0.4 19.2 20 0 0 20 20 20 0 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 001322133.1_26229001_2 - 0.029 14.6 71.4 0.37 11.0 1.5 10.1 3 2 6 12 12 12 0 zinc-finger-containing domain tRNA-synt_2d PF01409.18 001322133.1_26229001_2 - 0.63 9.3 9.7 10 5.4 0.0 5.2 5 2 2 7 7 7 0 tRNA synthetases class II core domain (F) FYDLN_acid PF09538.8 001322133.1_26229001_2 - 7.4 7.2 44.6 34 5.0 0.1 13.9 1 1 15 16 16 16 0 Protein of unknown function (FYDLN_acid) Corona_7 PF02398.14 001322133.1_26229001_3 - 3 8.3 12.0 64 4.1 0.0 6.0 7 1 0 7 7 7 0 Coronavirus protein 7 Cyclin_N PF00134.21 001191833.1_45723001_1 - 1e-14 54.3 0.2 1.7e-14 53.6 0.2 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.9 001191833.1_45723001_1 - 1.6e-11 44.7 0.0 2.3e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Cyclin zf-CCCH PF00642.22 001134865.1_45727001_3 - 2.1e-16 59.3 41.5 0.00037 20.2 8.1 6.0 4 2 1 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.3 001134865.1_45727001_3 - 1.6e-07 31.8 31.7 0.045 14.3 0.5 5.4 1 1 4 5 5 5 5 Torus domain zf-CCCH_3 PF15663.3 001134865.1_45727001_3 - 0.17 12.0 19.7 0.037 14.2 7.5 2.7 1 1 1 2 2 2 0 Zinc-finger containing family zf-C3H1 PF10650.7 001134865.1_45727001_3 - 3.5 7.3 6.7 2.8 7.6 0.1 3.5 3 0 0 3 3 3 0 Putative zinc-finger domain Archease PF01951.14 178547.3_26223001_2 - 4.3e-45 153.2 0.1 5.4e-45 152.9 0.1 1.1 1 0 0 1 1 1 1 Archease protein family (MTH1598/TM1083) DEAD_2 PF06733.13 001191857.1_45729001_1 - 3.1e-56 189.6 3.5 5.5e-56 188.8 3.5 1.4 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.4 001191857.1_45729001_1 - 8e-56 188.7 0.0 2.2e-55 187.3 0.0 1.8 1 0 0 1 1 1 1 Helicase C-terminal domain ResIII PF04851.13 001191857.1_45729001_1 - 7e-08 32.5 0.8 3.4e-06 27.1 0.2 2.7 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit CCM2_C PF16545.3 001191857.1_45729001_1 - 6.3e-05 23.3 0.1 0.01 16.2 0.0 2.6 2 0 0 2 2 2 1 Cerebral cavernous malformation protein, harmonin-homology DEAD PF00270.27 001191857.1_45729001_1 - 0.0011 18.7 0.1 0.12 12.0 0.1 2.5 1 1 0 1 1 1 1 DEAD/DEAH box helicase SNF2_N PF00176.21 001191857.1_45729001_1 - 0.0015 17.2 0.3 0.012 14.3 0.3 2.1 1 1 0 1 1 1 1 SNF2 family N-terminal domain C1_2 PF03107.14 001191857.1_45729001_1 - 0.072 13.3 3.9 0.29 11.4 3.9 2.1 1 0 0 1 1 1 0 C1 domain HBB PF06777.9 001191857.1_45729001_1 - 0.11 12.0 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Helical and beta-bridge domain zf-C3HC4_3 PF13920.4 001191857.1_45729001_1 - 0.29 10.9 12.9 1.1 9.0 12.9 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Homeobox PF00046.27 001191995.1_45722001_1 - 7.3e-22 76.8 1.8 1.1e-21 76.2 1.8 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001191995.1_45722001_1 - 0.024 14.4 0.0 0.081 12.7 0.0 1.9 1 0 0 1 1 1 0 Homeobox KN domain Shisa PF13908.4 001191922.1_45724001_1 - 3.1e-40 138.3 8.2 3.1e-40 138.3 8.2 1.9 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator bZIP_C PF12498.6 001191922.1_45724001_1 - 0.62 10.9 2.8 4 8.3 0.2 2.4 2 0 0 2 2 2 0 Basic leucine-zipper C terminal DUF1180 PF06679.10 001191922.1_45724001_1 - 1.2 9.4 9.7 0.45 10.8 1.4 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1180) Pkinase_Tyr PF07714.15 001319443.1_29524001_1 - 2.1e-94 315.5 0.0 2.6e-94 315.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001319443.1_29524001_1 - 1.6e-45 155.4 0.0 2.2e-45 155.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 001319443.1_29524001_1 - 3.1e-25 87.9 0.0 6e-25 87.0 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 001319443.1_29524001_1 - 3.4e-17 61.7 0.0 7.6e-17 60.5 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 001319443.1_29524001_1 - 1.3e-10 40.8 0.0 3.3e-10 39.5 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001319443.1_29524001_1 - 1.6e-09 37.2 0.0 3.6e-09 36.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain COX15-CtaA PF02628.13 001033699.4_45727001_3 - 1.1e-109 366.3 6.6 1.5e-109 365.9 6.6 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein Peptidase_S3 PF00944.17 001033699.4_45727001_3 - 0.19 11.4 0.1 0.3 10.8 0.1 1.2 1 0 0 1 1 1 0 Alphavirus core protein PRY PF13765.4 001135033.2_45728001_3 - 9.6e-18 63.4 0.3 2.6e-17 62.1 0.3 1.8 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 001135033.2_45728001_3 - 4.4e-12 46.0 0.1 7.8e-12 45.2 0.1 1.4 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.22 001135033.2_45728001_3 - 5.7e-08 32.7 7.6 5.7e-08 32.7 7.6 3.1 2 1 0 2 2 2 1 B-box zinc finger PAX PF00292.16 001191984.1_45724001_1 - 5.3e-74 246.0 0.8 8.6e-74 245.3 0.8 1.3 1 0 0 1 1 1 1 'Paired box' domain Homeobox PF00046.27 001191984.1_45724001_1 - 1.2e-23 82.6 6.8 2.7e-23 81.4 6.8 1.7 1 0 0 1 1 1 1 Homeobox domain Pax7 PF12360.6 001191984.1_45724001_1 - 7.9e-20 70.7 9.7 1.8e-19 69.5 9.7 1.6 1 0 0 1 1 1 1 Paired box protein 7 Homeobox_KN PF05920.9 001191984.1_45724001_1 - 5.4e-05 22.9 1.6 9.3e-05 22.1 0.8 1.9 2 0 0 2 2 2 1 Homeobox KN domain HTH_23 PF13384.4 001191984.1_45724001_1 - 6.4e-05 22.5 2.1 0.0025 17.4 0.1 2.6 2 0 0 2 2 2 1 Homeodomain-like domain HTH_32 PF13565.4 001191984.1_45724001_1 - 6.9e-05 23.3 6.2 0.0026 18.2 0.0 3.4 2 2 1 3 3 3 2 Homeodomain-like domain HTH_Tnp_IS1 PF12759.5 001191984.1_45724001_1 - 0.15 11.6 0.0 0.35 10.4 0.0 1.5 1 0 0 1 1 1 0 InsA C-terminal domain HLH PF00010.24 001191852.1_45723001_1 - 2.3e-05 24.2 0.2 3.7e-05 23.5 0.2 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Homeobox PF00046.27 001107961.2_45729001_1 - 1.4e-21 75.9 3.6 2.9e-21 74.9 3.6 1.5 1 0 0 1 1 1 1 Homeobox domain OAR PF03826.15 001107961.2_45729001_1 - 8.1e-05 22.2 1.2 8.1e-05 22.2 1.2 2.0 2 0 0 2 2 2 1 OAR domain Homeobox_KN PF05920.9 001107961.2_45729001_1 - 0.059 13.2 0.1 0.13 12.1 0.1 1.6 1 0 0 1 1 1 0 Homeobox KN domain Calsarcin PF05556.9 001305139.1_45728001_1 - 4.2e-05 23.0 0.0 0.077 12.3 0.0 2.7 2 1 0 2 2 2 2 Calcineurin-binding protein (Calsarcin) DUF3915 PF13054.4 001305139.1_45728001_1 - 0.13 12.1 13.4 0.24 11.3 13.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) FAM27 PF15832.3 001305139.1_45728001_1 - 8.1 6.9 10.0 28 5.2 10.0 1.9 1 0 0 1 1 1 0 FAM27 D and E protein family DUF3915 PF13054.4 001305139.1_45728001_2 - 0.003 17.4 5.7 0.0053 16.6 5.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3915) DUF3915 PF13054.4 001305139.1_45728001_3 - 2.4 8.0 13.5 4 7.3 13.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) PCI PF01399.25 001316358.1_26224001_1 - 1.6e-19 70.3 1.6 2.9e-19 69.4 0.2 2.1 2 0 0 2 2 2 1 PCI domain TPR_1 PF00515.26 001316358.1_26224001_1 - 0.014 15.1 2.7 0.023 14.4 0.9 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.15 001316358.1_26224001_1 - 0.035 14.1 2.1 0.22 11.6 0.9 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.10 001316358.1_26224001_1 - 0.096 13.3 1.0 0.24 12.0 1.0 1.7 1 0 0 1 1 1 0 Sel1 repeat TPR_8 PF13181.4 001316358.1_26224001_1 - 0.45 10.7 3.5 2.1 8.6 0.4 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat MFS_1 PF07690.14 001191637.1_45724001_1 - 2.3e-37 128.6 44.5 8.1e-26 90.6 16.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.5 001191637.1_45724001_1 - 0.0015 17.3 14.9 0.012 14.4 0.0 3.2 2 1 1 3 3 3 2 MFS_1 like family Gate PF07670.12 001191637.1_45724001_1 - 0.0026 17.9 1.7 0.6 10.3 0.0 2.8 1 1 1 2 2 2 1 Nucleoside recognition PDZ PF00595.22 001191963.1_45729001_3 - 6.3e-11 42.4 0.0 1.4e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Calsarcin PF05556.9 001191963.1_45729001_3 - 4.5e-09 36.0 0.3 0.00097 18.5 0.0 3.7 3 0 0 3 3 3 3 Calcineurin-binding protein (Calsarcin) PDZ_2 PF13180.4 001191963.1_45729001_3 - 0.014 15.5 0.0 0.044 14.0 0.0 1.8 1 0 0 1 1 1 0 PDZ domain TNF PF00229.16 001305916.1_29722001_1 - 3.7e-34 117.3 2.4 5.2e-34 116.8 2.4 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family SSP160 PF06933.9 001305916.1_29722001_3 - 0.47 8.5 6.0 0.57 8.2 6.0 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 FSA_C PF10479.7 001305916.1_29722001_3 - 0.55 8.2 2.9 0.71 7.8 2.9 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Amidase_2 PF01510.23 001191961.1_45723001_2 - 4.4e-28 98.1 0.0 9.6e-15 55.0 0.0 2.1 2 0 0 2 2 2 2 N-acetylmuramoyl-L-alanine amidase Homeobox_KN PF05920.9 001319609.1_29522001_2 - 1.4e-17 63.2 1.0 2.5e-17 62.4 1.0 1.4 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.27 001319609.1_29522001_2 - 1.9e-06 27.4 0.2 4.4e-06 26.3 0.2 1.6 1 0 0 1 1 1 1 Homeobox domain Nucleos_tra2_C PF07662.11 001321721.1_26225001_2 - 5.7e-45 153.8 0.4 5.7e-45 153.8 0.4 2.7 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.18 001321721.1_26225001_2 - 2.2e-23 82.5 3.2 2.2e-23 82.5 3.2 4.5 6 0 0 6 6 6 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.12 001321721.1_26225001_2 - 1e-06 28.8 8.8 1e-06 28.8 8.8 2.7 3 0 0 3 3 3 1 Nucleoside recognition PAN_4 PF14295.4 001306070.1_26229001_1 - 0.29 10.9 4.7 0.68 9.7 4.7 1.7 1 0 0 1 1 1 0 PAN domain zf-CCCH PF00642.22 001306070.1_26229001_2 - 2e-09 37.0 19.2 0.00085 19.0 0.7 4.8 4 0 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.3 001306070.1_26229001_2 - 5.5e-06 26.5 7.7 0.01 15.9 0.6 2.7 2 0 0 2 2 2 2 Zinc-finger containing family zf-CCCH_2 PF14608.4 001306070.1_26229001_2 - 0.0032 17.7 24.7 1.1 9.7 1.4 5.1 4 0 0 4 4 4 4 RNA-binding, Nab2-type zinc finger Torus PF16131.3 001306070.1_26229001_2 - 0.067 13.8 18.6 1.7 9.2 0.3 4.4 2 2 2 4 4 4 0 Torus domain NUDIX PF00293.26 001305426.1_45723001_1 - 1.3e-09 38.0 0.0 2.1e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain NACHT PF05729.10 001105240.2_39729001_1 - 8.1e-41 139.6 0.1 1.9e-40 138.4 0.1 1.7 1 0 0 1 1 1 1 NACHT domain CARD PF00619.19 001105240.2_39729001_1 - 1.9e-29 101.4 0.1 1.2e-21 76.4 0.0 3.1 2 0 0 2 2 2 2 Caspase recruitment domain LRR_6 PF13516.4 001105240.2_39729001_1 - 2.9e-17 61.1 16.4 0.0041 16.9 0.3 8.8 8 0 0 8 8 8 4 Leucine Rich repeat LRR_4 PF12799.5 001105240.2_39729001_1 - 0.00036 20.7 12.8 0.43 10.9 1.7 5.4 2 2 4 6 6 6 1 Leucine Rich repeats (2 copies) AAA_16 PF13191.4 001105240.2_39729001_1 - 0.00047 20.4 0.7 0.0033 17.7 0.2 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.4 001105240.2_39729001_1 - 0.0048 16.5 0.0 0.012 15.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.4 001105240.2_39729001_1 - 0.01 16.0 0.0 0.026 14.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain LRR_8 PF13855.4 001105240.2_39729001_1 - 0.013 15.2 12.3 0.11 12.2 0.7 4.6 2 2 3 5 5 5 0 Leucine rich repeat AAA_30 PF13604.4 001105240.2_39729001_1 - 0.025 14.2 0.0 0.05 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.4 001105240.2_39729001_1 - 0.075 12.5 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.20 001105240.2_39729001_1 - 0.09 11.7 0.0 0.21 10.5 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain ABC_tran PF00005.25 001105240.2_39729001_1 - 0.15 12.4 0.0 0.31 11.4 0.0 1.4 1 0 0 1 1 1 0 ABC transporter ubiquitin PF00240.21 198781.3_45723001_2 - 1e-07 31.4 0.0 1.7e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.4 198781.3_45723001_2 - 0.00039 20.4 0.0 0.00067 19.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 198781.3_45723001_2 - 0.22 11.9 0.0 0.39 11.2 0.0 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain dbPDZ_assoc PF16610.3 198781.3_45723001_2 - 1.1 9.5 9.0 1.9 8.7 9.0 1.3 1 0 0 1 1 1 0 Unstructured region between two PDZ domains on Dlg5 DUF4131 PF13567.4 198781.3_45723001_2 - 4.3 6.8 11.6 37 3.7 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) ELM2 PF01448.22 027422.3_32926001_2 - 1.1e-07 32.4 0.0 3.3e-07 30.9 0.0 1.9 1 0 0 1 1 1 1 ELM2 domain Myb_DNA-binding PF00249.29 027422.3_32926001_2 - 3.9e-05 23.6 0.6 0.0001 22.3 0.6 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain NHS PF15273.4 001191733.1_45729001_3 - 6.7e-215 715.8 50.8 6.7e-215 715.8 50.8 2.2 2 0 0 2 2 2 1 NHS-like fn3 PF00041.19 001191704.1_45728001_1 - 9.3e-92 301.4 0.0 3e-10 40.1 0.0 10.4 10 1 0 10 10 10 9 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 001191704.1_45728001_1 - 2e-23 82.6 3.7 0.12 12.8 0.1 8.9 8 1 0 8 8 8 7 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.7 001191704.1_45728001_1 - 3.5e-11 43.3 0.0 0.9 9.9 0.0 6.5 6 1 0 6 6 6 4 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.8 001191704.1_45728001_1 - 2.1e-09 37.5 5.2 11 6.2 0.0 7.9 8 0 0 8 8 8 3 Interferon-alpha/beta receptor, fibronectin type III I-set PF07679.14 001191704.1_45728001_1 - 0.023 14.6 0.1 8.5 6.4 0.0 3.3 3 0 0 3 3 3 0 Immunoglobulin I-set domain Pkinase PF00069.23 021135.5_26229001_1 - 9.2e-146 484.0 0.0 2.1e-73 246.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 021135.5_26229001_1 - 1.1e-75 254.1 0.0 2.9e-40 138.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.4 021135.5_26229001_1 - 2.4e-11 43.4 0.0 1.1e-05 24.8 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.12 021135.5_26229001_1 - 6.6e-09 35.3 0.0 0.00017 20.9 0.0 2.2 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_C PF00433.22 021135.5_26229001_1 - 7.1e-07 29.7 1.0 1.6e-06 28.5 1.0 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain APH PF01636.21 021135.5_26229001_1 - 5e-06 26.5 0.0 0.2 11.4 0.0 3.2 2 1 1 3 3 3 2 Phosphotransferase enzyme family FTA2 PF13095.4 021135.5_26229001_1 - 0.00052 19.6 0.3 4.6 6.7 0.0 3.2 3 0 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.7 021135.5_26229001_1 - 0.0039 16.6 0.0 0.39 10.1 0.0 2.3 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL RIO1 PF01163.20 021135.5_26229001_1 - 0.021 14.3 0.0 0.57 9.6 0.0 2.3 2 0 0 2 2 2 0 RIO1 family Robl_LC7 PF03259.15 001319157.1_26223001_1 - 1.5e-22 79.0 0.0 2.5e-22 78.3 0.0 1.3 1 0 0 1 1 1 1 Roadblock/LC7 domain LAMTOR5 PF16672.3 001319157.1_26223001_1 - 0.004 16.9 0.0 0.0068 16.2 0.0 1.3 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 DuoxA PF10204.7 001191965.1_45722001_1 - 6.9e-111 369.6 4.7 7.9e-111 369.4 4.7 1.0 1 0 0 1 1 1 1 Dual oxidase maturation factor TMEM40 PF15817.3 001191965.1_45722001_1 - 0.0018 17.8 2.7 0.26 10.9 0.2 2.4 2 0 0 2 2 2 2 Transmembrane protein 40 family DUF2428 PF10350.7 001191769.1_45729001_1 - 1.1e-93 313.3 4.7 1.3e-93 313.0 0.1 3.1 3 0 0 3 3 3 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.20 001191769.1_45729001_1 - 3.6e-08 32.8 0.6 3.7 7.9 0.0 7.6 7 0 0 7 7 7 3 HEAT repeat Hydrolase_like PF13242.4 001318765.1_26225001_2 - 2.2e-17 62.8 0.0 3.8e-17 62.0 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.4 001318765.1_26225001_2 - 1.8e-08 34.3 0.0 3.2e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD_2 PF13419.4 001318765.1_26225001_2 - 7.5e-05 22.7 0.0 0.00012 22.1 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.24 001318765.1_26225001_2 - 0.02 15.0 0.0 0.04 14.1 0.0 1.4 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Trypsin PF00089.24 001309433.1_45728001_2 - 6.6e-21 75.0 0.0 6.6e-21 75.0 0.0 2.5 3 0 0 3 3 3 1 Trypsin Gla PF00594.18 001309433.1_45728001_2 - 2.3e-20 72.4 8.5 3.7e-20 71.7 8.5 1.3 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain EGF PF00008.25 001309433.1_45728001_2 - 2.8e-08 33.8 25.6 6.6e-07 29.4 6.9 3.3 3 0 0 3 3 3 2 EGF-like domain FXa_inhibition PF14670.4 001309433.1_45728001_2 - 3.8e-08 33.3 10.5 3.8e-08 33.3 10.5 3.6 4 0 0 4 4 4 2 Coagulation Factor Xa inhibitory site hEGF PF12661.5 001309433.1_45728001_2 - 9.5e-06 26.0 3.5 9.5e-06 26.0 3.5 3.9 3 0 0 3 3 3 2 Human growth factor-like EGF cEGF PF12662.5 001309433.1_45728001_2 - 0.0032 17.2 2.8 0.0032 17.2 2.8 3.5 3 0 0 3 3 3 2 Complement Clr-like EGF-like EGF_CA PF07645.13 001309433.1_45728001_2 - 0.0054 16.8 25.0 0.12 12.5 6.5 3.4 3 0 0 3 3 3 2 Calcium-binding EGF domain DUF1986 PF09342.9 001309433.1_45728001_2 - 0.023 15.0 0.0 0.049 13.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Plasmod_Pvs28 PF06247.9 001309433.1_45728001_2 - 5.6 7.2 11.9 9.5 6.5 0.4 2.7 2 0 0 2 2 2 0 Pvs28 EGF domain EGF_3 PF12947.5 001309433.1_45728001_2 - 5.7 7.1 23.1 0.062 13.4 4.3 3.5 2 1 1 3 3 3 0 EGF domain Latrophilin PF02354.14 001302212.1_45729001_1 - 7.6e-136 452.9 18.0 6.4e-102 341.3 4.3 2.2 1 1 1 2 2 2 2 Latrophilin Cytoplasmic C-terminal region OLF PF02191.14 001302212.1_45729001_1 - 1.5e-83 280.1 5.5 2.3e-83 279.4 5.5 1.2 1 0 0 1 1 1 1 Olfactomedin-like domain 7tm_2 PF00002.22 001302212.1_45729001_1 - 3.4e-67 226.2 23.5 5.3e-67 225.5 23.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GAIN PF16489.3 001302212.1_45729001_1 - 5.1e-52 176.2 1.3 7.4e-52 175.7 1.3 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Gal_Lectin PF02140.16 001302212.1_45729001_1 - 9.7e-24 83.5 0.7 2.3e-23 82.3 0.7 1.7 1 0 0 1 1 1 1 Galactose binding lectin domain GPS PF01825.19 001302212.1_45729001_1 - 1.4e-13 51.1 4.7 4e-13 49.6 4.7 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif HRM PF02793.20 001302212.1_45729001_1 - 2.5e-09 37.1 1.5 6.3e-09 35.9 1.5 1.7 1 0 0 1 1 1 1 Hormone receptor domain DUF5074 PF16819.3 001302212.1_45729001_1 - 0.81 9.6 5.2 3.4 7.6 1.7 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF5074) ATP-synt_ab PF00006.23 001107867.2_45725001_2 - 2.2e-65 220.2 0.0 2.9e-65 219.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.21 001107867.2_45725001_2 - 7.8e-12 45.4 0.2 1.3e-11 44.7 0.2 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Rtf2 PF04641.10 001107867.2_45725001_2 - 3.7 6.7 0.0 3.7 6.7 0.0 2.9 2 1 0 2 2 2 0 Rtf2 RING-finger DUF1510 PF07423.9 001107867.2_45725001_2 - 6.1 6.1 26.0 12 5.1 26.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CDC37_M PF08565.9 017913.3_26228001_3 - 3.8e-21 75.1 0.8 6.5e-21 74.3 0.2 1.7 1 1 1 2 2 2 1 Cdc37 Hsp90 binding domain Lectin_C PF00059.19 001029908.1_45722001_1 - 3e-14 53.5 3.5 3e-14 53.5 3.5 1.8 2 0 0 2 2 2 1 Lectin C-type domain Ly49 PF08391.8 001029908.1_45722001_1 - 0.027 14.7 0.2 0.027 14.7 0.2 2.6 1 1 1 2 2 2 0 Ly49-like protein, N-terminal region UL45 PF05473.10 001029908.1_45722001_1 - 0.76 9.3 4.9 2.9 7.4 4.9 2.1 1 1 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Lys PF00062.18 001308588.1_39521001_1 - 4.3e-55 185.1 5.4 4.9e-55 185.0 5.4 1.0 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family SLT PF01464.18 001308588.1_39521001_1 - 0.005 16.4 0.0 0.0064 16.0 0.0 1.2 1 0 0 1 1 1 1 Transglycosylase SLT domain Mad3_BUB1_I PF08311.10 138540.1_45729001_2 - 7.4e-43 145.3 0.6 1.7e-42 144.2 0.6 1.6 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Pkinase PF00069.23 138540.1_45729001_2 - 6.9e-06 25.5 0.3 1.6e-05 24.3 0.3 1.6 1 0 0 1 1 1 1 Protein kinase domain Mad3_BUB1_II PF08171.9 138540.1_45729001_2 - 0.094 12.7 0.3 0.24 11.4 0.3 1.6 1 0 0 1 1 1 0 Mad3/BUB1 homology region 2 Vir_act_alpha_C PF10400.7 138540.1_45729001_2 - 1.6 9.3 6.8 11 6.7 0.1 2.8 2 0 0 2 2 2 0 Virulence activator alpha C-term Y_phosphatase PF00102.25 001042359.3_26226001_1 - 3.7e-34 118.2 0.3 5.1e-34 117.7 0.3 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.18 001042359.3_26226001_1 - 0.0022 17.6 0.1 0.0039 16.9 0.1 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 001042359.3_26226001_1 - 0.005 16.7 0.0 0.0075 16.1 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.4 001042359.3_26226001_1 - 0.076 13.0 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate Folliculin PF11704.6 001191919.1_45727001_3 - 2.7e-08 33.7 0.1 6e-08 32.6 0.1 1.5 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport V-SNARE PF05008.13 145206.3_26229001_3 - 6.5e-25 87.2 0.6 1.4e-24 86.1 0.6 1.6 1 0 0 1 1 1 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.6 145206.3_26229001_3 - 1.7e-19 69.7 6.2 1.7e-19 69.7 6.2 1.7 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.11 145206.3_26229001_3 - 0.048 13.4 0.2 0.14 11.9 0.2 1.7 1 0 0 1 1 1 0 Sec20 Laminin_II PF06009.10 145206.3_26229001_3 - 0.11 12.3 0.7 0.92 9.4 0.0 2.2 2 0 0 2 2 2 0 Laminin Domain II Exonuc_VII_L PF02601.13 145206.3_26229001_3 - 6.1 6.2 7.8 15 4.9 7.8 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit Homeobox PF00046.27 001310552.1_31322001_2 - 1.6e-19 69.3 6.3 2.9e-19 68.5 6.3 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.9 001310552.1_31322001_2 - 0.13 12.1 0.9 0.34 10.7 0.0 2.2 3 0 0 3 3 3 0 Homeobox KN domain Pkinase PF00069.23 001271135.1_45724001_3 - 5.8e-73 245.4 0.0 8e-73 244.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001271135.1_45724001_3 - 1.5e-45 155.4 0.0 2e-45 155.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase MIT PF04212.16 001271135.1_45724001_3 - 5.9e-32 109.4 19.7 1.1e-18 66.9 3.2 2.7 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain Kdo PF06293.12 001271135.1_45724001_3 - 0.00014 21.2 0.1 0.00029 20.1 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.18 001271135.1_45724001_3 - 0.11 11.9 0.0 0.49 9.8 0.0 1.9 1 1 1 2 2 2 0 Choline/ethanolamine kinase RIO1 PF01163.20 001271135.1_45724001_3 - 0.11 11.9 0.1 0.21 11.0 0.1 1.4 1 0 0 1 1 1 0 RIO1 family CbtA_toxin PF06755.10 001271135.1_45724001_3 - 0.17 11.7 0.0 0.36 10.6 0.0 1.5 1 0 0 1 1 1 0 CbtA_toxin of type IV toxin-antitoxin system Peptidase_M10 PF00413.22 001171139.2_37924001_2 - 5.3e-61 205.0 0.1 9.6e-61 204.1 0.1 1.5 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.17 001171139.2_37924001_2 - 3.9e-43 145.0 16.2 2.5e-15 56.0 0.3 4.9 5 0 0 5 5 5 4 Hemopexin PG_binding_1 PF01471.16 001171139.2_37924001_2 - 4.9e-13 49.0 0.9 8.7e-13 48.1 0.3 1.8 2 0 0 2 2 2 1 Putative peptidoglycan binding domain Astacin PF01400.22 001171139.2_37924001_2 - 0.00054 19.5 0.1 0.73 9.3 0.0 2.4 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.4 001171139.2_37924001_2 - 0.015 15.7 0.0 0.027 14.9 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.4 001171139.2_37924001_2 - 0.019 15.0 0.1 0.033 14.2 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_4 PF13583.4 001171139.2_37924001_2 - 0.023 14.2 0.0 0.037 13.5 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.3 001171139.2_37924001_2 - 0.083 12.0 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Met-zincin Big_2 PF02368.16 001191900.1_45729001_1 - 1.6e-11 43.8 21.5 4e-08 32.9 0.4 6.2 7 0 0 7 7 7 2 Bacterial Ig-like domain (group 2) T2SS-T3SS_pil_N PF13629.4 001191900.1_45729001_1 - 0.0054 16.3 1.0 0.76 9.5 0.1 4.5 4 0 0 4 4 4 1 Pilus formation protein N terminal region SNF2_N PF00176.21 001310530.1_32929001_1 - 6e-59 199.4 0.4 1.1e-58 198.5 0.4 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain BRK PF07533.14 001310530.1_32929001_1 - 3.1e-30 103.4 0.0 1.8e-15 56.1 0.1 2.5 2 0 0 2 2 2 2 BRK domain Chromo PF00385.22 001310530.1_32929001_1 - 2.9e-25 87.8 6.6 6.1e-12 45.1 0.2 2.7 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.29 001310530.1_32929001_1 - 4.5e-17 62.3 0.0 2.3e-16 60.0 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 001310530.1_32929001_1 - 1.6e-06 28.1 0.0 5.1e-06 26.5 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.27 001310530.1_32929001_1 - 0.00061 19.5 0.0 0.001 18.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase CHDCT2 PF08074.9 001310530.1_32929001_1 - 0.00079 19.5 0.0 0.86 9.6 0.0 3.7 3 0 0 3 3 3 1 CHDCT2 (NUC038) domain HDA2-3 PF11496.6 001310530.1_32929001_1 - 0.0024 17.0 0.0 0.0095 15.0 0.0 1.9 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Peptidase_M10 PF00413.22 001310530.1_32929001_1 - 0.012 15.3 0.1 0.97 9.1 0.0 2.4 2 0 0 2 2 2 0 Matrixin Gemin7 PF11095.6 001319054.1_26222001_1 - 7.7e-33 112.1 0.1 1.2e-32 111.4 0.1 1.3 1 0 0 1 1 1 1 Gem-associated protein 7 (Gemin7) SUZ-C PF12901.5 001319054.1_26222001_1 - 0.012 15.5 0.1 0.037 13.9 0.1 1.8 1 0 0 1 1 1 0 SUZ-C motif DUF896 PF05979.10 001319054.1_26222001_1 - 0.15 11.8 0.2 0.28 10.9 0.2 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF896) DUF1115 PF06544.10 001322335.1_26228001_2 - 1.2e-11 44.7 0.2 5.6e-11 42.6 0.2 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF1115) RWD PF05773.20 001322335.1_26228001_2 - 5e-10 39.6 0.0 8.7e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 RWD domain TRPM_tetra PF16519.3 001354180.1_45729001_1 - 5.5e-24 83.9 5.4 1.3e-23 82.7 5.4 1.7 1 0 0 1 1 1 1 Tetramerisation domain of TRPM Ion_trans PF00520.29 001354180.1_45729001_1 - 2e-18 66.4 14.5 3.4e-18 65.7 14.5 1.3 1 0 0 1 1 1 1 Ion transport protein DUF3552 PF12072.6 001354180.1_45729001_1 - 0.039 13.2 4.3 0.081 12.2 4.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Reo_sigmaC PF04582.10 001354180.1_45729001_1 - 0.12 11.6 0.7 0.21 10.8 0.7 1.3 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DegS PF05384.9 001354180.1_45729001_1 - 1.3 8.3 6.0 0.48 9.8 1.9 2.2 2 0 0 2 2 2 0 Sensor protein DegS Peptidase_M19 PF01244.19 001319405.1_29524001_3 - 1.8e-103 346.0 0.0 2.1e-103 345.7 0.0 1.1 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Pyr_excise PF03013.12 001319405.1_29524001_3 - 0.14 12.0 0.0 0.56 10.1 0.0 1.9 2 0 0 2 2 2 0 Pyrimidine dimer DNA glycosylase CD4-extracel PF09191.8 001305921.1_29723001_1 - 5.2e-47 158.6 0.8 5.2e-47 158.6 0.8 2.9 4 0 0 4 4 4 1 CD4, extracellular C2-set PF05790.13 001305921.1_29723001_1 - 6.5e-38 128.7 10.1 1.3e-20 73.2 0.1 4.1 4 0 0 4 4 4 2 Immunoglobulin C2-set domain ig PF00047.23 001305921.1_29723001_1 - 1.1e-21 76.7 7.6 2.2e-17 62.9 0.2 4.2 4 1 0 4 4 4 2 Immunoglobulin domain Tcell_CD4_C PF12104.6 001305921.1_29723001_1 - 5.5e-16 58.0 6.7 5.5e-16 58.0 6.7 2.0 2 0 0 2 2 1 1 T cell CD4 receptor C terminal region Ig_3 PF13927.4 001305921.1_29723001_1 - 1.3e-13 51.2 4.4 4.1e-07 30.4 0.1 3.7 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 001305921.1_29723001_1 - 1.3e-12 47.7 0.7 5.4e-09 36.1 0.1 3.0 3 0 0 3 3 3 2 Immunoglobulin V-set domain I-set PF07679.14 001305921.1_29723001_1 - 1.8e-12 47.0 3.0 1.3e-07 31.4 0.9 4.1 4 1 0 4 4 4 2 Immunoglobulin I-set domain Ig_2 PF13895.4 001305921.1_29723001_1 - 1.3e-10 41.4 4.8 0.00019 21.6 0.5 3.9 3 1 0 3 3 3 2 Immunoglobulin domain Receptor_2B4 PF11465.6 001305921.1_29723001_1 - 0.00018 21.6 0.5 0.0012 18.9 0.3 2.4 2 0 0 2 2 2 1 Natural killer cell receptor 2B4 Ig_5 PF16681.3 001305921.1_29723001_1 - 0.0048 17.1 2.1 2.9 8.3 2.6 3.4 2 1 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain DUF4493 PF14900.4 001305921.1_29723001_1 - 0.012 15.6 0.0 0.087 12.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4493) Izumo-Ig PF16706.3 001305921.1_29723001_1 - 0.062 13.2 0.0 23 5.0 0.0 3.2 3 1 0 3 3 3 0 Izumo-like Immunoglobulin domain P_proprotein PF01483.18 001305921.1_29723001_1 - 0.068 13.1 0.0 0.19 11.7 0.0 1.8 1 0 0 1 1 1 0 Proprotein convertase P-domain Herpes_gE PF02480.14 001305921.1_29723001_1 - 0.07 11.7 0.1 0.66 8.5 0.0 2.1 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E Pilin PF00114.17 001305921.1_29723001_1 - 0.15 12.8 2.2 0.65 10.8 0.0 2.7 3 0 0 3 3 3 0 Pilin (bacterial filament) UCH PF00443.27 001136470.1_45729001_3 - 2.1e-55 187.8 0.1 2.9e-55 187.4 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.17 001136470.1_45729001_3 - 1.1e-18 67.2 9.3 1.1e-18 67.2 9.3 3.4 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.4 001136470.1_45729001_3 - 3.6e-15 56.2 0.8 1.5e-10 41.1 0.1 2.1 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase HSNSD PF12062.6 001191716.1_45726001_1 - 4.7e-247 820.4 0.0 6.1e-247 820.0 0.0 1.1 1 0 0 1 1 1 1 heparan sulfate-N-deacetylase Sulfotransfer_1 PF00685.25 001191716.1_45726001_1 - 7.7e-42 143.5 0.0 1.2e-41 142.8 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.4 001191716.1_45726001_1 - 1.4e-07 32.0 0.1 0.0031 17.8 0.0 2.7 1 1 1 2 2 2 2 Sulfotransferase family Kelch_1 PF01344.23 001308112.1_26229001_1 - 8e-69 226.9 11.5 7.6e-14 50.9 0.1 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 001308112.1_26229001_1 - 1.7e-40 135.9 5.1 7.8e-08 32.2 0.4 5.9 3 3 3 6 6 6 5 Kelch motif BACK PF07707.13 001308112.1_26229001_1 - 2.8e-34 117.2 0.5 4.8e-34 116.4 0.5 1.4 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.29 001308112.1_26229001_1 - 4.8e-30 103.9 0.9 9.9e-30 102.9 0.9 1.6 1 0 0 1 1 1 1 BTB/POZ domain Kelch_2 PF07646.13 001308112.1_26229001_1 - 1.1e-24 85.2 4.6 0.00033 20.4 0.1 5.8 5 1 0 5 5 5 5 Kelch motif Kelch_3 PF13415.4 001308112.1_26229001_1 - 1.4e-22 79.3 2.7 0.0026 17.8 0.3 5.7 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.4 001308112.1_26229001_1 - 4.2e-16 58.5 0.2 0.0036 17.1 0.0 5.6 4 1 1 5 5 5 5 Galactose oxidase, central domain Kelch_5 PF13854.4 001308112.1_26229001_1 - 1.4e-10 40.7 5.2 0.052 13.4 0.2 4.8 4 0 0 4 4 4 3 Kelch motif Ank_2 PF12796.5 001107178.3_45729001_2 - 1.6e-33 115.0 1.2 2.1e-19 69.7 0.2 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001107178.3_45729001_2 - 9.5e-33 112.0 2.1 7.9e-16 58.1 0.1 4.2 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.4 001107178.3_45729001_2 - 2.6e-28 97.5 3.7 1.4e-11 44.2 0.3 5.0 3 1 2 5 5 5 4 Ankyrin repeats (many copies) PRKG1_interact PF15898.3 001107178.3_45729001_2 - 4.1e-28 98.1 23.3 4.1e-28 98.1 23.3 4.4 5 0 0 5 5 5 1 cGMP-dependent protein kinase interacting domain Ank PF00023.28 001107178.3_45729001_2 - 1.3e-22 79.0 4.8 7.6e-05 22.8 0.0 5.9 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.4 001107178.3_45729001_2 - 2.4e-21 73.4 2.2 0.00015 21.8 0.0 6.2 6 0 0 6 6 6 5 Ankyrin repeat PRKG1_interact PF15898.3 001107178.3_45729001_3 - 4.1e-10 40.4 0.5 8e-10 39.4 0.5 1.4 1 0 0 1 1 1 1 cGMP-dependent protein kinase interacting domain Latrophilin PF02354.14 001302208.1_45729001_1 - 1e-162 541.3 6.8 1.5e-162 540.8 6.8 1.2 1 0 0 1 1 1 1 Latrophilin Cytoplasmic C-terminal region OLF PF02191.14 001302208.1_45729001_1 - 1.6e-83 280.0 5.5 2.4e-83 279.4 5.5 1.2 1 0 0 1 1 1 1 Olfactomedin-like domain 7tm_2 PF00002.22 001302208.1_45729001_1 - 1.7e-65 220.6 20.4 2.6e-65 220.0 20.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GAIN PF16489.3 001302208.1_45729001_1 - 5.5e-52 176.1 1.3 7.7e-52 175.6 1.3 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Gal_Lectin PF02140.16 001302208.1_45729001_1 - 1e-23 83.4 0.7 2.4e-23 82.2 0.7 1.7 1 0 0 1 1 1 1 Galactose binding lectin domain GPS PF01825.19 001302208.1_45729001_1 - 1.4e-13 51.1 4.7 4.1e-13 49.6 4.7 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif HRM PF02793.20 001302208.1_45729001_1 - 2.6e-09 37.1 1.5 6.5e-09 35.8 1.5 1.7 1 0 0 1 1 1 1 Hormone receptor domain DUF5074 PF16819.3 001302208.1_45729001_1 - 0.84 9.6 5.2 3.4 7.6 1.7 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF5074) Hormone_1 PF00103.18 001009309.3_39522001_1 - 2.4e-65 220.2 0.1 3.1e-65 219.8 0.1 1.1 1 0 0 1 1 1 1 Somatotropin hormone family DUF2205 PF10224.7 001009309.3_39522001_1 - 0.049 13.5 0.0 0.34 10.8 0.0 2.1 2 0 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) zf-H2C2_2 PF13465.4 001305018.1_26227001_1 - 2e-21 75.2 20.4 9.3e-08 32.1 1.1 5.0 4 0 0 4 4 4 3 Zinc-finger double domain KRAB PF01352.25 001305018.1_26227001_1 - 4e-21 74.3 0.0 6.9e-21 73.5 0.0 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2 PF00096.24 001305018.1_26227001_1 - 2.7e-12 46.3 21.7 0.0002 21.5 1.2 4.8 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 001305018.1_26227001_1 - 6.9e-05 22.6 20.4 0.00039 20.2 0.2 4.5 4 0 0 4 4 4 1 C2H2-type zinc finger zf-C2H2_4 PF13894.4 001305018.1_26227001_1 - 0.00077 20.0 30.7 0.021 15.5 0.9 5.2 5 0 0 5 5 4 3 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001305018.1_26227001_1 - 0.0027 17.3 16.7 0.36 10.5 0.6 4.2 4 0 0 4 4 4 3 zinc-finger C2H2-type DUF3268 PF11672.6 001305018.1_26227001_1 - 0.013 15.7 4.6 0.42 10.8 0.4 2.2 2 0 0 2 2 2 0 zinc-finger-containing domain zf-RING_7 PF02591.13 001305018.1_26227001_1 - 0.014 15.5 9.1 0.68 10.0 0.9 3.1 3 0 0 3 3 2 0 C4-type zinc ribbon domain Zn-ribbon_8 PF09723.8 001305018.1_26227001_1 - 0.018 15.0 1.9 0.018 15.0 1.9 3.5 4 0 0 4 4 4 0 Zinc ribbon domain zf-C2H2_jaz PF12171.6 001305018.1_26227001_1 - 0.042 14.1 0.4 25 5.2 0.1 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding HypA PF01155.17 001305018.1_26227001_1 - 0.86 9.5 3.7 15 5.5 3.7 2.3 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.5 001305018.1_26227001_1 - 1.4 8.9 10.8 65 3.5 10.8 2.9 1 1 0 1 1 1 0 Double zinc ribbon zf-met PF12874.5 001305018.1_26227001_1 - 2 8.8 9.0 3.4 8.0 0.2 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type TerY_C PF15616.4 001305018.1_26227001_1 - 2.1 8.4 5.3 11 6.1 0.6 2.6 2 1 1 3 3 3 0 TerY-C metal binding domain DUF2256 PF10013.7 001305018.1_26227001_1 - 5.3 7.1 13.1 1.4 8.9 0.1 3.9 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) ERbeta_N PF12497.6 001305018.1_26227001_2 - 1.2 8.8 4.4 0.49 10.1 0.7 2.2 2 0 0 2 2 2 0 Estrogen receptor beta SH3_1 PF00018.26 001314003.1_45725001_3 - 5.3e-16 57.8 0.1 1.6e-15 56.3 0.1 1.9 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 001314003.1_45725001_3 - 4.8e-12 45.2 0.0 8.8e-12 44.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 001314003.1_45725001_3 - 4.2e-09 36.0 0.0 1.5e-08 34.2 0.0 2.0 1 0 0 1 1 1 1 Variant SH3 domain hSH3 PF14603.4 001314003.1_45725001_3 - 0.12 12.8 0.0 0.34 11.4 0.0 1.7 1 0 0 1 1 1 0 Helically-extended SH3 domain SH3_3 PF08239.9 001314003.1_45725001_3 - 0.16 12.1 0.6 0.48 10.6 0.0 2.1 3 0 0 3 3 3 0 Bacterial SH3 domain Presenilin PF01080.15 001314003.1_45725001_3 - 1 7.9 7.9 1.8 7.1 7.9 1.2 1 0 0 1 1 1 0 Presenilin zf-DHHC PF01529.18 001039342.2_45723001_1 - 6.7e-30 103.8 9.3 6.7e-30 103.8 9.3 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase Pou PF00157.15 172085.2_45729001_2 - 1.5e-37 127.3 0.2 2.7e-37 126.5 0.2 1.4 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 172085.2_45729001_2 - 4.5e-18 64.7 0.3 1.3e-17 63.2 0.3 1.8 1 0 0 1 1 1 1 Homeobox domain DUF2722 PF10846.6 172085.2_45729001_2 - 0.00034 19.5 6.4 0.00052 19.0 6.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) HTH_31 PF13560.4 172085.2_45729001_2 - 0.039 14.2 0.0 0.51 10.6 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain Homeobox_KN PF05920.9 172085.2_45729001_2 - 0.071 12.9 0.0 0.19 11.5 0.0 1.7 1 0 0 1 1 1 0 Homeobox KN domain Spt20 PF12090.6 172085.2_45729001_2 - 0.23 10.9 20.7 0.42 10.1 20.7 1.3 1 0 0 1 1 1 0 Spt20 family DUF3915 PF13054.4 172085.2_45729001_2 - 1.4 8.8 9.5 3.2 7.6 9.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Med3 PF11593.6 172085.2_45729001_2 - 4.6 6.2 11.7 7.6 5.5 11.7 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal SARAF PF06682.10 172085.2_45729001_2 - 4.7 6.7 16.1 23 4.4 0.1 3.0 3 0 0 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis Suf PF05843.12 172085.2_45729001_2 - 6.3 6.5 9.9 11 5.7 9.9 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF3915 PF13054.4 172085.2_45729001_3 - 2.5 8.0 6.5 6.3 6.7 6.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Cytochrom_C PF00034.19 012840.3_45722001_1 - 6.7e-12 46.2 0.1 9.5e-12 45.8 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.4 012840.3_45722001_1 - 6.7e-05 23.0 1.3 0.00016 21.8 1.3 1.7 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.4 012840.3_45722001_1 - 0.0018 17.9 1.9 0.013 15.0 1.9 2.1 1 1 0 1 1 1 1 Cytochrome c-550 domain DUF3668 PF12416.6 001191697.1_45729001_2 - 1e-93 313.2 1.1 3.1e-93 311.6 0.0 2.2 2 0 0 2 2 2 1 Cep120 protein C2 PF00168.28 001191697.1_45729001_2 - 9.1e-09 35.4 0.0 0.0042 17.2 0.0 3.4 3 0 0 3 3 3 3 C2 domain Acyl_transf_1 PF00698.19 001191788.1_45724001_1 - 1.2e-21 77.4 0.0 1.8e-21 76.8 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain Na_Ca_ex PF01699.22 053505.2_45728001_2 - 2e-56 190.1 39.7 6e-29 100.8 14.7 2.4 2 0 0 2 2 2 2 Sodium/calcium exchanger protein CENP-B_dimeris PF09026.8 053505.2_45728001_2 - 0.018 15.3 7.7 0.035 14.4 7.7 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.10 053505.2_45728001_2 - 0.071 12.4 3.8 0.12 11.6 3.8 1.2 1 0 0 1 1 1 0 NOA36 protein SPC25 PF06703.9 053505.2_45728001_2 - 0.23 11.1 3.2 0.1 12.2 0.2 2.0 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Arrestin_N PF00339.27 001190993.1_45723001_1 - 7.5e-34 116.8 0.0 3.2e-32 111.5 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.20 001190993.1_45723001_1 - 9e-17 61.6 0.1 1.4e-16 60.9 0.1 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain CBM49 PF09478.8 001190993.1_45723001_1 - 0.044 13.9 0.3 0.081 13.1 0.3 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain CBM49 Homeobox PF00046.27 001191702.1_45729001_2 - 3.2e-67 222.1 20.5 1.1e-17 63.4 0.5 4.9 4 0 0 4 4 4 4 Homeobox domain Homeobox_KN PF05920.9 001191702.1_45729001_2 - 6.7e-13 48.2 3.1 0.028 14.2 0.1 4.8 4 0 0 4 4 4 4 Homeobox KN domain zf-C2H2 PF00096.24 001191702.1_45729001_2 - 1.1e-12 47.5 154.1 0.0057 16.9 0.3 22.8 24 0 0 24 24 23 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001191702.1_45729001_2 - 2.3e-09 37.1 146.9 0.28 12.0 0.3 23.3 24 0 0 24 24 23 11 C2H2-type zinc finger zf-H2C2_5 PF13909.4 001191702.1_45729001_2 - 1e-06 28.2 72.9 0.00061 19.4 0.8 10.9 10 0 0 10 10 10 5 C2H2-type zinc-finger domain zf-met PF12874.5 001191702.1_45729001_2 - 7.4e-05 22.9 97.1 0.00029 21.0 1.1 16.2 16 0 0 16 16 16 7 Zinc-finger of C2H2 type zf-Di19 PF05605.10 001191702.1_45729001_2 - 0.00011 22.3 8.0 0.00011 22.3 8.0 10.7 11 0 0 11 11 11 4 Drought induced 19 protein (Di19), zinc-binding MerR_1 PF13411.4 001191702.1_45729001_2 - 0.0053 16.7 0.2 0.061 13.3 0.0 2.9 3 0 0 3 3 3 1 MerR HTH family regulatory protein zf-C2H2_6 PF13912.4 001191702.1_45729001_2 - 0.014 15.2 0.3 0.014 15.2 0.3 13.2 15 0 0 15 15 15 0 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001191702.1_45729001_2 - 0.11 12.1 0.0 0.11 12.1 0.0 9.7 11 0 0 11 11 11 0 zinc-finger C2H2-type zf-C2H2_2 PF12756.5 001191702.1_45729001_2 - 0.12 12.6 121.0 1.8 8.8 2.3 19.2 15 6 5 20 20 19 0 C2H2 type zinc-finger (2 copies) GAGA PF09237.9 001191702.1_45729001_2 - 5.4 6.8 23.7 24 4.7 1.9 6.3 6 0 0 6 6 6 0 GAGA factor CH PF00307.29 001106755.2_45729001_1 - 2.1e-42 143.6 0.1 3.6e-20 72.0 0.2 2.4 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.6 001106755.2_45729001_1 - 1e-05 25.1 0.0 0.0062 16.2 0.0 2.5 2 0 0 2 2 2 2 CAMSAP CH domain GKAP PF03359.11 022946.3_45729001_3 - 6.4e-154 512.5 5.8 6.4e-154 512.5 5.8 2.5 3 0 0 3 3 3 1 Guanylate-kinase-associated protein (GKAP) protein PQ-loop PF04193.12 001191647.1_45725001_3 - 6e-37 125.1 19.4 8.6e-20 70.1 5.7 2.9 2 0 0 2 2 2 2 PQ loop repeat DUF4929 PF16283.3 001191647.1_45725001_3 - 0.033 13.1 0.1 0.048 12.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4929) DUF2721 PF11026.6 001191647.1_45725001_3 - 0.051 13.3 1.4 0.14 11.9 1.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) SCAN PF02023.15 014519.3_26224001_3 - 3.9e-41 138.6 3.0 8.5e-41 137.6 3.0 1.6 1 0 0 1 1 1 1 SCAN domain zf-H2C2_2 PF13465.4 014519.3_26224001_3 - 1.7e-34 116.6 33.8 2.3e-08 33.9 0.4 6.9 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.24 014519.3_26224001_3 - 2.3e-25 87.5 33.6 7.3e-07 29.2 1.0 5.9 6 0 0 6 6 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 014519.3_26224001_3 - 6.9e-13 48.1 30.4 0.0038 17.8 0.7 5.8 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_6 PF13912.4 014519.3_26224001_3 - 6.6e-10 38.6 24.3 0.15 11.9 0.7 5.8 5 0 0 5 5 5 5 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 014519.3_26224001_3 - 7.1e-05 22.7 19.6 0.02 14.9 3.4 3.8 2 1 1 3 3 3 3 Zinc ribbon domain XPA_N PF01286.16 014519.3_26224001_3 - 0.0012 18.8 21.8 0.2 11.6 0.4 5.3 5 0 0 5 5 5 2 XPA protein N-terminal zf-trcl PF13451.4 014519.3_26224001_3 - 0.0064 16.2 16.4 8.4 6.2 0.1 5.4 5 0 0 5 5 5 0 Probable zinc-ribbon domain DZR PF12773.5 014519.3_26224001_3 - 0.087 12.7 15.4 0.86 9.5 5.2 3.2 1 1 1 2 2 2 0 Double zinc ribbon HypA PF01155.17 014519.3_26224001_3 - 0.11 12.4 11.6 4 7.4 3.7 3.2 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.3 014519.3_26224001_3 - 0.12 13.1 15.0 0.43 11.2 1.4 3.2 1 1 2 3 3 3 0 zinc-ribbon family zf-C2H2_jaz PF12171.6 014519.3_26224001_3 - 0.14 12.4 16.8 2.4 8.4 0.1 5.2 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding YhfH PF14149.4 014519.3_26224001_3 - 0.55 10.1 17.0 22 5.0 0.1 5.5 5 0 0 5 5 5 0 YhfH-like protein zf-C2H2_11 PF16622.3 014519.3_26224001_3 - 0.68 9.6 18.1 0.16 11.6 0.3 5.0 5 0 0 5 5 5 0 zinc-finger C2H2-type zf-LYAR PF08790.9 014519.3_26224001_3 - 0.72 9.7 14.0 0.72 9.7 0.3 4.5 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger DUF3268 PF11672.6 014519.3_26224001_3 - 0.87 9.8 12.0 0.47 10.7 1.4 2.9 1 1 1 3 3 3 0 zinc-finger-containing domain DUF2321 PF10083.7 014519.3_26224001_3 - 2.1 7.9 12.4 1.4 8.4 1.8 3.1 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2321) ADK_lid PF05191.12 014519.3_26224001_3 - 2.1 8.3 12.8 4.1 7.4 1.7 4.1 3 1 2 5 5 4 0 Adenylate kinase, active site lid CpXC PF14353.4 014519.3_26224001_3 - 4 7.4 12.2 7.4 6.5 0.0 4.6 2 1 1 3 3 3 0 CpXC protein zf-AN1 PF01428.14 014519.3_26224001_3 - 4.5 7.4 22.9 18 5.5 0.2 5.4 4 1 1 5 5 5 0 AN1-like Zinc finger TFIIS_C PF01096.16 014519.3_26224001_3 - 4.6 7.0 19.1 12 5.7 0.4 5.4 5 0 0 5 5 5 0 Transcription factor S-II (TFIIS) C1_4 PF07975.10 014519.3_26224001_3 - 5.7 7.1 16.2 3.7 7.8 1.3 3.6 2 1 2 4 4 4 0 TFIIH C1-like domain zinc_ribbon_4 PF13717.4 014519.3_26224001_3 - 6 6.7 16.2 27 4.7 0.1 5.1 5 0 0 5 5 5 0 zinc-ribbon domain EF-hand_7 PF13499.4 001191081.1_45722001_1 - 5.6e-14 52.2 2.5 6.6e-11 42.4 0.9 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 001191081.1_45722001_1 - 7.5e-11 40.9 3.7 0.0016 18.1 0.1 3.7 2 1 1 3 3 3 3 EF-hand domain EF-hand_1 PF00036.30 001191081.1_45722001_1 - 5.3e-09 34.9 9.5 0.00024 20.3 0.2 3.9 4 1 0 4 4 4 3 EF hand EF-hand_5 PF13202.4 001191081.1_45722001_1 - 0.00026 20.2 5.9 0.0021 17.4 0.3 3.6 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.4 001191081.1_45722001_1 - 0.001 18.6 5.5 0.022 14.4 0.3 3.2 2 2 1 3 3 3 1 EF-hand domain pair Anth_Ig PF05587.11 001191081.1_45722001_1 - 0.11 12.9 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 Anthrax receptor extracellular domain Exonuc_VII_S PF02609.14 001191081.1_45722001_1 - 0.19 11.7 1.1 1.1 9.2 0.1 2.5 2 1 1 3 3 3 0 Exonuclease VII small subunit ApoO PF09769.7 001313733.1_32923001_3 - 1.6e-35 121.8 0.0 2.4e-35 121.2 0.0 1.2 1 0 0 1 1 1 1 Apolipoprotein O Pkinase PF00069.23 001322435.1_22424001_1 - 5.5e-78 261.8 0.0 7e-78 261.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001322435.1_22424001_1 - 2.8e-35 121.7 0.0 4.3e-35 121.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.27 001322435.1_22424001_1 - 7.7e-17 61.6 0.2 1.6e-16 60.5 0.2 1.6 1 0 0 1 1 1 1 PH domain Pkinase_C PF00433.22 001322435.1_22424001_1 - 1.6e-10 41.4 3.0 3.7e-10 40.2 3.0 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 001322435.1_22424001_1 - 1.6e-08 34.1 0.0 1.2e-07 31.3 0.0 2.0 2 0 0 2 2 2 1 Kinase-like PH_11 PF15413.4 001322435.1_22424001_1 - 0.0052 17.1 0.4 0.017 15.4 0.0 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain Seadorna_VP7 PF07387.9 001322435.1_22424001_1 - 0.052 12.5 0.0 0.083 11.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.21 001322435.1_22424001_1 - 0.13 12.0 0.0 0.48 10.2 0.0 1.8 1 1 0 2 2 2 0 Phosphotransferase enzyme family PAP2 PF01569.19 030791.3_26227001_2 - 1.6e-14 53.7 5.3 3.9e-14 52.5 5.3 1.6 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.4 030791.3_26227001_2 - 4.1e-05 23.2 2.9 8.1e-05 22.2 2.9 1.5 1 0 0 1 1 1 1 PAP2 superfamily Sushi PF00084.18 001009118.3_39723001_1 - 4e-44 148.9 26.6 1.9e-12 47.5 0.7 5.2 5 0 0 5 5 5 4 Sushi repeat (SCR repeat) Sushi_2 PF09014.8 001009118.3_39723001_1 - 7e-36 122.0 5.5 1.6e-35 120.8 5.5 1.6 1 0 0 1 1 1 1 Beta-2-glycoprotein-1 fifth domain DUF842 PF05811.11 001009118.3_39723001_1 - 0.087 12.5 2.0 0.13 11.9 2.0 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) HRM PF02793.20 001009118.3_39723001_1 - 0.93 9.7 12.8 2.8 8.2 0.3 4.1 4 0 0 4 4 4 0 Hormone receptor domain cEGF PF12662.5 001009118.3_39723001_1 - 1.4 8.8 15.6 8.1 6.3 0.2 4.5 4 0 0 4 4 4 0 Complement Clr-like EGF-like zinc_ribbon_12 PF11331.6 001009118.3_39723001_2 - 0.025 14.2 2.1 4.2 7.1 0.4 2.7 2 0 0 2 2 2 0 Probable zinc-ribbon domain ENTH PF01417.18 021852.3_45729001_2 - 4e-52 175.4 1.2 5.2e-52 175.0 0.1 1.7 2 0 0 2 2 2 1 ENTH domain ANTH PF07651.14 021852.3_45729001_2 - 8.7e-06 24.8 0.1 1.3e-05 24.2 0.1 1.2 1 0 0 1 1 1 1 ANTH domain VHS PF00790.17 021852.3_45729001_2 - 0.002 17.8 0.2 0.0041 16.8 0.2 1.5 1 0 0 1 1 1 1 VHS domain TNF PF00229.16 145681.2_45723001_1 - 7.6e-44 148.6 0.7 1.1e-43 148.0 0.7 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1q PF00386.19 145681.2_45723001_1 - 0.11 12.5 2.0 5.2 7.1 2.0 2.3 1 1 0 1 1 1 0 C1q domain CFTR_R PF14396.4 145681.2_45723001_1 - 0.12 11.8 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 Cystic fibrosis TM conductance regulator (CFTR), regulator domain DUF773 PF05600.10 001308183.1_32925001_2 - 1e-127 426.9 1.2 1.3e-127 426.6 1.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF773) FimP PF09766.7 001308183.1_32925001_2 - 5.9 5.9 11.8 1.9 7.5 0.3 2.2 2 0 0 2 2 2 0 Fms-interacting protein DUF773 PF05600.10 001308183.1_32925001_3 - 4.1e-44 151.1 0.4 5.1e-44 150.7 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF773) Ig_2 PF13895.4 133277.3_26225001_3 - 0.00077 19.6 0.0 0.0012 19.0 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 133277.3_26225001_3 - 0.00089 19.3 0.0 0.0013 18.7 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 133277.3_26225001_3 - 0.0018 18.7 0.0 0.0029 18.0 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain 3Beta_HSD PF01073.17 001310567.1_31324001_3 - 2.6e-112 374.3 0.0 3.3e-112 373.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 001310567.1_31324001_3 - 3.7e-23 82.1 0.0 4.9e-23 81.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.10 001310567.1_31324001_3 - 5.2e-18 65.0 0.1 1.4e-17 63.6 0.1 1.6 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.3 001310567.1_31324001_3 - 5.6e-13 48.8 0.0 2.4e-12 46.7 0.0 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.4 001310567.1_31324001_3 - 2.1e-11 44.0 0.0 3.1e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.13 001310567.1_31324001_3 - 7.8e-11 41.5 0.1 1.5e-10 40.6 0.0 1.4 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NmrA PF05368.11 001310567.1_31324001_3 - 7.7e-07 28.8 0.0 1.2e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.15 001310567.1_31324001_3 - 4.7e-06 25.8 0.0 6.5e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.8 001310567.1_31324001_3 - 0.00013 21.8 0.1 0.00032 20.5 0.1 1.6 1 1 0 1 1 1 1 KR domain Ldh_1_N PF00056.21 001310567.1_31324001_3 - 0.03 14.3 0.0 0.049 13.6 0.0 1.2 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain DapB_N PF01113.18 001310567.1_31324001_3 - 0.039 13.9 0.1 0.12 12.3 0.1 1.8 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus zf-C2H2 PF00096.24 080405.2_45729001_1 - 2.7e-19 68.3 34.1 0.00034 20.8 0.5 6.1 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 080405.2_45729001_1 - 2.5e-12 46.5 30.9 7.9e-07 29.1 1.4 5.3 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.4 080405.2_45729001_1 - 5.5e-07 29.7 28.7 0.0048 17.5 0.3 5.8 5 0 0 5 5 5 3 C2H2-type zinc finger FOXP-CC PF16159.3 080405.2_45729001_1 - 5.9e-06 26.7 20.7 0.027 15.0 4.8 5.0 1 1 3 4 4 4 2 FOXP coiled-coil domain zf-C2H2_aberr PF17017.3 080405.2_45729001_1 - 0.92 9.5 15.4 6.4 6.7 2.3 3.4 2 1 1 3 3 3 0 Aberrant zinc-finger PcF PF09461.8 080405.2_45729001_1 - 5.4 7.3 5.4 41 4.5 0.3 3.4 2 1 1 3 3 3 0 Phytotoxin PcF protein IL17 PF06083.9 080405.2_45729001_1 - 8.2 6.8 6.5 1.1 9.6 0.2 2.9 3 0 0 3 3 3 0 Interleukin-17 DM PF00751.16 001191761.1_45723001_1 - 3.7e-20 71.4 9.5 3.7e-20 71.4 9.5 1.5 2 0 0 2 2 2 1 DM DNA binding domain zf-AN1 PF01428.14 001191761.1_45723001_3 - 0.14 12.2 0.2 0.25 11.4 0.2 1.4 1 0 0 1 1 1 0 AN1-like Zinc finger Beta-Casp PF10996.6 001033892.2_45725001_3 - 4.8e-26 91.1 0.0 2e-25 89.1 0.0 2.1 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B_6 PF16661.3 001033892.2_45725001_3 - 5.6e-23 81.2 0.0 1.2e-22 80.2 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.10 001033892.2_45725001_3 - 4.2e-17 61.7 0.0 8.6e-17 60.7 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.25 001033892.2_45725001_3 - 9.2e-11 42.0 0.0 5e-08 33.1 0.0 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.5 001033892.2_45725001_3 - 4.1e-08 32.8 0.7 1e-07 31.6 0.1 1.9 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.4 001033892.2_45725001_3 - 5.9e-05 22.9 0.0 0.00093 19.0 0.0 2.5 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.3 001033892.2_45725001_3 - 0.00034 19.8 0.0 0.001 18.2 0.0 1.7 1 1 0 1 1 1 1 Putative beta-lactamase-like family Acyltransferase PF01553.19 001321527.1_26227001_1 - 0.0007 19.1 0.0 0.0023 17.4 0.0 1.8 2 0 0 2 2 2 1 Acyltransferase SPT6_acidic PF14632.4 001305263.1_45722001_2 - 1.6 9.2 8.6 1.3 9.5 7.3 1.6 1 1 1 2 2 2 0 Acidic N-terminal SPT6 NDK PF00334.17 001191884.1_45723001_1 - 1.2e-36 125.6 0.0 1.7e-36 125.1 0.0 1.2 1 0 0 1 1 1 1 Nucleoside diphosphate kinase CHDCT2 PF08074.9 001271226.2_45729001_2 - 8.8e-91 302.6 0.9 2e-90 301.4 0.9 1.7 1 0 0 1 1 1 1 CHDCT2 (NUC038) domain SNF2_N PF00176.21 001271226.2_45729001_2 - 4.9e-61 206.3 0.7 7.7e-61 205.6 0.0 1.7 2 0 0 2 2 2 1 SNF2 family N-terminal domain DUF1086 PF06461.9 001271226.2_45729001_2 - 5.8e-61 204.2 0.0 2.3e-60 202.3 0.0 2.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) DUF1087 PF06465.11 001271226.2_45729001_2 - 9.7e-26 89.5 6.1 9.7e-26 89.5 6.1 3.1 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1087) CHDNT PF08073.10 001271226.2_45729001_2 - 4.5e-25 87.2 0.3 1.1e-24 85.9 0.3 1.7 1 0 0 1 1 1 1 CHDNT (NUC034) domain Helicase_C PF00271.29 001271226.2_45729001_2 - 1.5e-21 76.7 0.0 2.9e-21 75.8 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.27 001271226.2_45729001_2 - 3.1e-21 74.9 26.5 1.5e-10 40.6 7.8 2.6 2 0 0 2 2 2 2 PHD-finger Chromo PF00385.22 001271226.2_45729001_2 - 6.6e-18 64.2 4.2 3.7e-12 45.8 0.6 3.0 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.13 001271226.2_45729001_2 - 8.9e-08 32.2 0.0 8.9e-08 32.2 0.0 2.5 2 0 0 2 2 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.6 001271226.2_45729001_2 - 8.3e-06 25.0 0.0 8.3e-06 25.0 0.0 2.1 2 1 0 2 2 1 1 Class II histone deacetylase complex subunits 2 and 3 PHD_2 PF13831.4 001271226.2_45729001_2 - 0.011 15.1 11.3 0.19 11.1 2.6 2.6 2 0 0 2 2 2 0 PHD-finger C1_1 PF00130.20 001271226.2_45729001_2 - 8 6.3 16.3 2.3 8.0 3.1 2.9 3 0 0 3 3 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-H2C2_2 PF13465.4 001191902.1_45723001_1 - 1.7e-14 53.4 25.3 7.9e-09 35.4 1.1 4.3 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.24 001191902.1_45723001_1 - 6.5e-13 48.2 30.2 5.7e-06 26.4 1.0 4.1 4 0 0 4 4 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001191902.1_45723001_1 - 3.8e-08 33.4 26.8 7.7e-05 23.1 1.8 4.0 4 0 0 4 4 3 3 C2H2-type zinc finger zf-Di19 PF05605.10 001191902.1_45723001_1 - 0.00074 19.6 1.5 0.00074 19.6 1.5 2.5 2 1 1 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.6 001191902.1_45723001_1 - 0.0012 19.0 4.0 0.45 10.7 0.8 3.5 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001191902.1_45723001_1 - 0.0014 18.3 11.0 0.012 15.4 0.7 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.5 001191902.1_45723001_1 - 0.0015 18.7 8.3 0.043 14.1 1.2 3.8 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.3 001191902.1_45723001_1 - 0.028 14.6 3.1 0.1 12.7 3.1 2.0 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_9 PF16293.3 001191902.1_45723001_1 - 0.057 13.1 0.2 0.22 11.2 0.1 2.0 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) zf-H2C2_5 PF13909.4 001191902.1_45723001_1 - 0.14 11.8 13.0 0.24 11.1 0.3 3.7 3 0 0 3 3 3 0 C2H2-type zinc-finger domain DUF2225 PF09986.7 001191902.1_45723001_1 - 0.19 11.3 0.0 0.4 10.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-C2H2_2 PF12756.5 001191902.1_45723001_1 - 0.53 10.5 3.6 1.7 8.9 1.0 2.5 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-BED PF02892.13 001191902.1_45723001_1 - 0.85 9.6 11.6 15 5.6 0.6 3.5 1 1 2 3 3 3 0 BED zinc finger zf-C2H2_aberr PF17017.3 001191902.1_45723001_1 - 1.3 9.0 3.8 3 7.8 0.1 2.1 2 0 0 2 2 2 0 Aberrant zinc-finger FOXP-CC PF16159.3 001191902.1_45723001_1 - 5 7.7 14.3 5 7.7 0.3 3.8 3 1 1 4 4 4 0 FOXP coiled-coil domain zf-C2HC_2 PF13913.4 001191902.1_45723001_1 - 8 6.4 12.8 1.7 8.5 1.0 3.1 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-RING_UBOX PF13445.4 001135714.2_45726001_3 - 1.4e-07 31.3 10.8 1.4e-07 31.3 10.8 2.5 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 001135714.2_45726001_3 - 5.8e-07 29.1 18.5 2.2e-06 27.3 18.5 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PRY PF13765.4 001135714.2_45726001_3 - 2.1e-06 27.1 0.5 1.2e-05 24.7 0.0 2.6 3 0 0 3 3 3 1 SPRY-associated domain zf-C3HC4 PF00097.23 001135714.2_45726001_3 - 3.9e-06 26.5 18.0 3.9e-06 26.5 18.0 2.1 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001135714.2_45726001_3 - 7.9e-06 25.5 14.9 7.9e-06 25.5 14.9 2.3 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001135714.2_45726001_3 - 4.2e-05 23.5 19.5 4.2e-05 23.5 19.5 2.2 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.22 001135714.2_45726001_3 - 8.6e-05 22.5 6.9 8.6e-05 22.5 6.9 3.7 3 0 0 3 3 2 1 B-box zinc finger zf-RING_2 PF13639.4 001135714.2_45726001_3 - 0.0021 18.1 19.2 0.0021 18.1 19.2 2.8 3 0 0 3 3 2 1 Ring finger domain Nup54 PF13874.4 001135714.2_45726001_3 - 0.022 14.7 3.2 0.042 13.8 3.2 1.4 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 APP_E2 PF12925.5 001135714.2_45726001_3 - 0.28 10.7 6.4 0.51 9.9 6.4 1.3 1 0 0 1 1 1 0 E2 domain of amyloid precursor protein HNOBA PF07701.12 001135714.2_45726001_3 - 0.69 9.2 2.9 1.4 8.2 1.5 2.1 2 0 0 2 2 2 0 Heme NO binding associated PRKG1_interact PF15898.3 001135714.2_45726001_3 - 2.1 9.2 8.6 5.2 7.9 8.6 1.6 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain ANF_receptor PF01094.26 001319439.1_29528001_3 - 5.2e-73 246.0 0.0 6.7e-73 245.7 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 001319439.1_29528001_3 - 5.1e-53 178.8 0.1 8e-53 178.2 0.1 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 001319439.1_29528001_3 - 2.2e-46 156.6 0.0 7.5e-46 154.9 0.0 1.9 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 001319439.1_29528001_3 - 1e-18 67.5 0.0 2e-18 66.5 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.4 001319439.1_29528001_3 - 2.7e-06 27.2 0.0 4.6e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Periplasmic binding protein MRVI1 PF05781.10 174392.3_06529001_2 - 7e-222 737.7 10.5 9e-222 737.3 10.5 1.1 1 0 0 1 1 1 1 MRVI1 protein Ribosomal_S5_C PF03719.13 031902.4_26227001_3 - 5.4e-19 67.3 0.0 8.5e-19 66.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.18 031902.4_26227001_3 - 2e-17 62.8 0.9 3.5e-17 62.0 0.9 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Collagen PF01391.16 001135759.1_45729001_1 - 5.3e-190 615.3 752.6 2.1e-09 36.8 30.4 27.2 4 4 21 27 27 27 27 Collagen triple helix repeat (20 copies) C4 PF01413.17 001135759.1_45729001_1 - 2.1e-79 262.9 1.9 2.5e-41 140.4 0.2 2.1 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen Folate_rec PF03024.12 001191817.1_45726001_1 - 1.6e-23 83.3 3.3 1.6e-23 83.3 3.3 2.3 2 0 0 2 2 2 1 Folate receptor family GSDH PF07995.9 001191817.1_45726001_1 - 3.3e-19 69.3 0.0 4.7e-19 68.7 0.0 1.2 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase EGF_2 PF07974.11 001191817.1_45726001_1 - 0.00065 19.9 8.2 0.00065 19.9 8.2 3.3 3 0 0 3 3 3 2 EGF-like domain Homeobox PF00046.27 001191746.1_45722001_1 - 1.1e-20 73.0 3.2 1.8e-20 72.4 3.2 1.3 1 0 0 1 1 1 1 Homeobox domain DLL_N PF12413.6 001191746.1_45722001_1 - 2.2e-19 70.3 18.1 2.2e-19 70.3 18.1 2.8 3 1 0 3 3 3 1 Homeobox protein distal-less-like N terminal Homeobox_KN PF05920.9 001191746.1_45722001_1 - 0.013 15.3 0.2 0.026 14.3 0.2 1.5 1 0 0 1 1 1 0 Homeobox KN domain DUF4149 PF13664.4 001321114.1_26222001_1 - 3.9e-25 88.0 10.2 2e-24 85.7 9.6 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) PhyH PF05721.11 001321114.1_26222001_1 - 0.14 12.3 0.0 0.2 11.7 0.0 1.1 1 0 0 1 1 1 0 Phytanoyl-CoA dioxygenase (PhyH) zf-H2C2_2 PF13465.4 001134957.1_45729001_2 - 2.8e-39 131.7 126.0 4e-07 30.1 0.2 20.8 20 1 0 20 20 20 12 Zinc-finger double domain zf-C2H2 PF00096.24 001134957.1_45729001_2 - 1.1e-34 116.8 160.5 7.7e-05 22.8 3.3 19.8 19 0 0 19 19 19 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001134957.1_45729001_2 - 3.3e-30 102.0 153.5 0.0054 17.3 2.9 19.6 19 0 0 19 19 19 16 C2H2-type zinc finger zf-H2C2_5 PF13909.4 001134957.1_45729001_2 - 1.1e-29 101.7 117.6 3.6e-09 36.1 0.5 15.3 16 1 0 16 16 16 9 C2H2-type zinc-finger domain zf-Di19 PF05605.10 001134957.1_45729001_2 - 4.2e-14 52.4 88.8 0.0029 17.7 1.0 12.6 11 1 1 12 12 12 8 Drought induced 19 protein (Di19), zinc-binding Rad50_zn_hook PF04423.12 001134957.1_45729001_2 - 0.0034 17.1 5.4 0.13 12.0 0.1 4.0 3 0 0 3 3 3 1 Rad50 zinc hook motif zf-C2H2_2 PF12756.5 001134957.1_45729001_2 - 0.0082 16.3 4.4 0.0082 16.3 4.4 14.7 5 2 9 15 15 15 3 C2H2 type zinc-finger (2 copies) zf-met PF12874.5 001134957.1_45729001_2 - 0.021 15.1 0.4 0.021 15.1 0.4 14.8 16 0 0 16 16 16 0 Zinc-finger of C2H2 type ARS2 PF04959.11 001134957.1_45729001_2 - 0.14 12.4 0.1 0.14 12.4 0.1 4.1 5 1 1 6 6 6 0 Arsenite-resistance protein 2 Myosin_tail_1 PF01576.17 001100690.1_45729001_3 - 0 1500.6 284.7 0 1500.3 284.7 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.19 001100690.1_45729001_3 - 5.3e-287 953.4 0.0 1e-286 952.5 0.0 1.5 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_N PF02736.17 001100690.1_45729001_3 - 9.6e-05 22.0 0.0 0.00021 20.9 0.0 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain ADIP PF11559.6 001100690.1_45729001_3 - 0.00059 19.8 16.8 0.00059 19.8 16.8 13.3 2 2 10 14 14 14 2 Afadin- and alpha -actinin-Binding IQ PF00612.25 001100690.1_45729001_3 - 0.00084 18.8 0.3 0.0031 17.0 0.3 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif AAA_22 PF13401.4 001100690.1_45729001_3 - 0.023 14.8 0.0 0.023 14.8 0.0 6.1 5 3 1 6 6 6 0 AAA domain Lipocalin PF00061.21 001082493.2_21022001_1 - 5.4e-36 123.8 0.0 6.7e-36 123.5 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Ig_3 PF13927.4 001271398.1_45727001_2 - 3.1e-43 146.1 0.0 6.7e-11 42.5 0.0 5.4 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.14 001271398.1_45727001_2 - 3.7e-31 106.9 0.0 1.4e-08 34.5 0.0 6.4 5 3 0 5 5 5 4 Immunoglobulin I-set domain Ig_2 PF13895.4 001271398.1_45727001_2 - 1.8e-26 92.2 0.0 3.2e-08 33.7 0.0 5.1 5 0 0 5 5 5 4 Immunoglobulin domain ig PF00047.23 001271398.1_45727001_2 - 8.8e-18 64.1 0.0 0.0044 17.0 0.0 6.2 6 0 0 6 6 6 4 Immunoglobulin domain C2-set_2 PF08205.10 001271398.1_45727001_2 - 2.8e-13 49.6 0.8 1.7e-08 34.3 0.0 4.5 5 0 0 5 5 5 2 CD80-like C2-set immunoglobulin domain V-set PF07686.15 001271398.1_45727001_2 - 2.2e-12 47.0 0.0 0.0048 16.9 0.0 5.9 4 2 1 5 5 5 4 Immunoglobulin V-set domain AAA_11 PF13086.4 001305276.1_45729001_1 - 4e-82 275.7 0.0 1.5e-59 201.7 0.0 3.5 2 1 1 3 3 3 3 AAA domain AAA_12 PF13087.4 001305276.1_45729001_1 - 3.3e-74 248.7 0.0 2.4e-46 157.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain RNB PF00773.17 001305276.1_45729001_1 - 6.5e-48 163.6 0.0 1.5e-47 162.4 0.0 1.6 1 1 0 1 1 1 1 RNB domain AAA_30 PF13604.4 001305276.1_45729001_1 - 2.6e-18 66.3 0.0 0.00021 20.9 0.0 4.6 5 1 0 5 5 5 3 AAA domain AAA_19 PF13245.4 001305276.1_45729001_1 - 1.7e-14 54.2 0.0 9e-06 25.9 0.0 4.5 5 1 0 5 5 5 2 AAA domain AAA_22 PF13401.4 001305276.1_45729001_1 - 1.3e-07 31.8 0.0 0.0093 16.1 0.0 2.9 2 0 0 2 2 2 2 AAA domain PhoH PF02562.14 001305276.1_45729001_1 - 3.4e-07 29.8 0.1 0.18 11.1 0.0 3.7 4 0 0 4 4 4 2 PhoH-like protein UvrD_C_2 PF13538.4 001305276.1_45729001_1 - 1.2e-06 28.1 0.2 9.7e-05 22.0 0.1 3.6 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain ResIII PF04851.13 001305276.1_45729001_1 - 1.8e-05 24.7 0.0 0.27 11.1 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit UvrD_C PF13361.4 001305276.1_45729001_1 - 2.3e-05 23.8 0.0 0.42 9.8 0.0 3.2 2 1 1 3 3 3 2 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.19 001305276.1_45729001_1 - 0.00017 21.1 0.0 0.031 13.7 0.0 2.6 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain DUF2075 PF09848.7 001305276.1_45729001_1 - 0.00019 20.6 0.0 0.002 17.3 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.12 001305276.1_45729001_1 - 0.006 16.3 0.0 0.017 14.8 0.0 1.8 1 0 0 1 1 1 1 Helicase Viral_helicase1 PF01443.16 001305276.1_45729001_1 - 0.0099 15.5 3.0 2.7 7.5 0.0 3.9 4 0 0 4 4 4 1 Viral (Superfamily 1) RNA helicase AAA_24 PF13479.4 001305276.1_45729001_1 - 0.014 15.0 0.0 0.47 10.0 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA PF00004.27 001305276.1_45729001_1 - 0.02 15.2 0.8 3.6 7.9 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.18 001305276.1_45729001_1 - 0.021 13.7 0.0 1.6 7.6 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_16 PF13191.4 001305276.1_45729001_1 - 0.023 15.0 0.0 5.5 7.2 0.0 2.8 2 0 0 2 2 2 0 AAA ATPase domain Bac_DnaA PF00308.16 001305276.1_45729001_1 - 0.066 12.9 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein DEAD PF00270.27 001305276.1_45729001_1 - 0.076 12.7 0.0 4.8 6.8 0.0 2.6 2 0 0 2 2 2 0 DEAD/DEAH box helicase zf-C2H2_jaz PF12171.6 001305276.1_45729001_1 - 0.084 13.1 4.8 0.2 11.8 4.8 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Terminase_6 PF03237.13 001305276.1_45729001_1 - 0.11 11.2 0.0 0.17 10.5 0.0 1.3 1 0 0 1 1 1 0 Terminase-like family AAA_5 PF07728.12 001305276.1_45729001_1 - 0.13 12.1 0.0 17 5.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) zf-met PF12874.5 001305276.1_45729001_1 - 0.25 11.7 6.4 0.67 10.3 6.4 1.8 1 0 0 1 1 1 0 Zinc-finger of C2H2 type GGACT PF06094.10 001310058.1_45723001_1 - 2.3e-22 79.7 0.0 3e-22 79.4 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.4 001310058.1_45723001_1 - 0.037 14.3 0.0 0.062 13.6 0.0 1.3 1 0 0 1 1 1 0 AIG2-like family Sirohm_synth_C PF14823.4 001310058.1_45723001_2 - 0.14 11.7 2.6 0.23 11.0 2.6 1.3 1 0 0 1 1 1 0 Sirohaem biosynthesis protein C-terminal zf-H2C2_2 PF13465.4 001308265.1_45729001_3 - 7.6e-30 101.9 54.9 1e-07 31.9 5.1 7.9 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.24 001308265.1_45729001_3 - 9.6e-19 66.6 81.6 0.00016 21.8 5.0 8.4 8 0 0 8 8 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001308265.1_45729001_3 - 2e-09 37.3 76.3 0.045 14.5 4.4 8.7 8 0 0 8 8 7 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001308265.1_45729001_3 - 2.7e-08 33.8 46.4 0.016 15.4 1.7 8.0 7 0 0 7 7 7 5 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.10 001308265.1_45729001_3 - 1.1e-07 31.9 25.5 2.4e-07 30.8 1.4 4.0 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.5 001308265.1_45729001_3 - 1.2e-05 25.4 52.5 0.034 14.4 2.4 7.5 7 0 0 7 7 7 5 Zinc-finger of C2H2 type Homeobox PF00046.27 001308265.1_45729001_3 - 3.4e-05 23.4 0.0 8.9e-05 22.1 0.0 1.6 1 0 0 1 1 1 1 Homeobox domain zf-C2H2_6 PF13912.4 001308265.1_45729001_3 - 0.0086 15.9 58.5 0.78 9.6 0.8 7.7 7 0 0 7 7 7 5 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001308265.1_45729001_3 - 0.39 10.7 21.1 0.13 12.2 2.9 5.0 4 0 0 4 4 4 0 Zinc ribbon domain Zip PF02535.20 001308265.1_45729001_3 - 0.77 8.8 7.4 2.2 7.3 7.4 1.8 1 0 0 1 1 1 0 ZIP Zinc transporter YL1 PF05764.11 001308265.1_45729001_3 - 0.83 9.6 36.4 0.011 15.8 25.2 2.6 2 0 0 2 2 2 0 YL1 nuclear protein zf-C2H2_9 PF16293.3 001308265.1_45729001_3 - 1.6 8.5 14.1 10 5.9 0.0 5.1 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) NPR3 PF03666.11 001308265.1_45729001_3 - 1.6 7.3 10.5 3.5 6.2 10.5 1.5 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 zf-C2H2_11 PF16622.3 001308265.1_45729001_3 - 2 8.1 27.6 0.15 11.8 0.5 6.1 5 0 0 5 5 5 0 zinc-finger C2H2-type zf-C2H2_2 PF12756.5 001308265.1_45729001_3 - 4.2 7.6 42.5 0.093 12.9 2.1 6.6 3 2 3 6 6 5 0 C2H2 type zinc-finger (2 copies) Nop14 PF04147.10 001308265.1_45729001_3 - 5.6 4.9 40.3 0.009 14.2 26.4 2.1 2 0 0 2 2 2 0 Nop14-like family Nup96 PF12110.6 031074.2_45729001_1 - 1e-98 329.9 5.4 1.6e-98 329.3 5.4 1.3 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.12 031074.2_45729001_1 - 9.1e-41 139.1 0.0 1.7e-40 138.2 0.0 1.5 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.4 031074.2_45729001_1 - 1.7e-05 25.5 194.1 4.7e-05 24.0 35.5 6.8 2 2 5 7 7 7 5 Nucleoporin FG repeat region ANAPC3 PF12895.5 031074.2_45729001_1 - 0.13 12.3 0.2 0.29 11.2 0.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 Patched PF02460.16 001191734.1_45726001_1 - 8.7e-100 334.9 17.8 1.3e-99 334.3 17.8 1.2 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.6 001191734.1_45726001_1 - 1.7e-18 66.8 0.8 1.7e-18 66.8 0.8 2.6 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Cadherin PF00028.15 001303145.1_26227001_2 - 3.4e-76 251.6 0.0 1.1e-17 64.1 0.0 5.8 6 0 0 6 6 6 5 Cadherin domain Cadherin_C_2 PF16492.3 001303145.1_26227001_2 - 2.7e-28 98.4 0.5 5.6e-28 97.4 0.5 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_2 PF08266.10 001303145.1_26227001_2 - 8.7e-14 51.0 1.1 7.2e-11 41.6 0.4 3.9 4 0 0 4 4 4 2 Cadherin-like Cadherin_3 PF16184.3 001303145.1_26227001_2 - 4.9e-09 36.0 0.5 0.0032 17.4 0.0 4.0 4 0 0 4 4 4 2 Cadherin-like He_PIG PF05345.10 001303145.1_26227001_2 - 0.079 13.0 2.8 19 5.4 0.0 4.5 5 1 0 5 5 5 0 Putative Ig domain Ets PF00178.20 001107107.1_45728001_1 - 5.1e-36 122.9 1.2 5.1e-36 122.9 1.2 2.2 2 0 0 2 2 2 1 Ets-domain SAM_PNT PF02198.14 001107107.1_45728001_1 - 1.1e-31 108.4 1.5 2.2e-31 107.5 1.5 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain zf-H2C2_2 PF13465.4 001107639.2_45729001_2 - 1.3e-25 88.4 42.6 4.9e-07 29.8 1.0 5.7 5 0 0 5 5 5 5 Zinc-finger double domain zf-C2H2 PF00096.24 001107639.2_45729001_2 - 8.1e-14 51.1 51.3 0.00031 20.9 0.2 6.2 6 0 0 6 6 6 5 Zinc finger, C2H2 type SET PF00856.26 001107639.2_45729001_2 - 7e-09 36.2 0.1 1.7e-08 34.9 0.1 1.6 1 0 0 1 1 1 1 SET domain zf-C2H2_6 PF13912.4 001107639.2_45729001_2 - 1.1e-06 28.3 35.2 0.00016 21.4 3.4 5.8 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_4 PF13894.4 001107639.2_45729001_2 - 2.6e-06 27.7 43.9 0.057 14.1 4.9 6.3 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001107639.2_45729001_2 - 0.0091 16.2 0.4 0.0091 16.2 0.4 5.1 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 001107639.2_45729001_2 - 0.31 11.4 37.7 0.021 15.1 3.1 5.9 5 0 0 5 5 5 0 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.8 001107639.2_45729001_2 - 3.6 7.7 13.7 7.3 6.7 1.6 4.1 3 1 0 3 3 3 0 Zinc ribbon domain DSPc PF00782.18 001320479.1_26224001_3 - 2.3e-30 105.0 0.0 3.3e-30 104.5 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 001320479.1_26224001_3 - 7e-05 22.9 0.0 0.00011 22.3 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.25 001320479.1_26224001_3 - 0.0011 18.5 0.1 0.0016 17.9 0.1 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase IRF-3 PF10401.7 001320479.1_26224001_3 - 0.0085 15.8 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 1 Interferon-regulatory factor 3 Peptidase_M3 PF01432.18 031052.2_45725001_3 - 9.6e-142 473.3 0.0 1.3e-141 472.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M91 PF14891.4 031052.2_45725001_3 - 0.055 13.6 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Effector protein FlhE PF06366.11 031052.2_45725001_3 - 0.14 12.0 0.2 21 5.0 0.0 2.4 2 0 0 2 2 2 0 Flagellar protein FlhE PDZ PF00595.22 001191879.3_45729001_1 - 2e-77 255.4 0.1 5.8e-19 68.1 0.0 4.5 4 0 0 4 4 4 4 PDZ domain (Also known as DHR or GLGF) LRR_8 PF13855.4 001191879.3_45729001_1 - 6.7e-33 112.1 45.0 1.6e-07 30.9 1.1 6.7 4 2 3 7 7 7 7 Leucine rich repeat PDZ_2 PF13180.4 001191879.3_45729001_1 - 6e-25 87.2 0.2 1.2e-07 31.8 0.0 4.5 4 0 0 4 4 4 4 PDZ domain LRR_4 PF12799.5 001191879.3_45729001_1 - 2.9e-24 84.5 41.3 0.00034 20.8 0.0 8.7 7 2 2 9 9 9 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001191879.3_45729001_1 - 6.3e-06 25.7 19.2 0.00086 18.7 2.7 4.6 2 1 4 6 6 6 4 Leucine-rich repeat Tricorn_PDZ PF14685.4 001191879.3_45729001_1 - 8.2e-06 25.6 0.3 1.3 8.9 0.0 3.6 3 0 0 3 3 3 3 Tricorn protease PDZ domain AbLIM_anchor PF16182.3 001191879.3_45729001_1 - 0.0016 18.2 0.1 0.0061 16.3 0.0 2.0 2 0 0 2 2 2 1 Putative adherens-junction anchoring region of AbLIM Ecl1 PF12855.5 001271040.1_45723001_1 - 0.14 11.6 0.2 0.34 10.3 0.2 1.6 1 0 0 1 1 1 0 Life-span regulatory factor ACC_epsilon PF13822.4 001271040.1_45723001_1 - 2.1 9.0 6.0 22 5.7 0.9 2.7 2 0 0 2 2 2 0 Acyl-CoA carboxylase epsilon subunit zf-U1 PF06220.10 001271040.1_45723001_2 - 1.7e-22 78.7 7.5 2.9e-22 78.0 7.5 1.4 1 0 0 1 1 1 1 U1 zinc finger zf-C2H2_jaz PF12171.6 001271040.1_45723001_2 - 3.3 8.0 9.8 29 5.0 9.8 2.4 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Lipocalin PF00061.21 001185065.1_49822001_1 - 1.1e-24 87.1 1.5 1.5e-24 86.7 1.5 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 001185065.1_49822001_1 - 0.0046 16.8 1.1 0.0075 16.1 1.1 1.3 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Y_phosphatase PF00102.25 001352542.1_26225001_3 - 1e-07 31.6 0.2 1.4e-07 31.2 0.2 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase RimK PF08443.9 001352270.1_26229001_2 - 1.6e-41 141.9 0.0 2.3e-41 141.3 0.0 1.2 1 0 0 1 1 1 1 RimK-like ATP-grasp domain GSH-S_ATP PF02955.14 001352270.1_26229001_2 - 1.1e-10 41.1 0.0 1.7e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATP-grasp_3 PF02655.12 001352270.1_26229001_2 - 3.1e-06 27.2 0.0 4.5e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.4 001352270.1_26229001_2 - 5.1e-05 22.5 2.1 0.091 11.9 0.4 3.1 1 1 1 2 2 2 2 Sugar-transfer associated ATP-grasp ATPgrasp_Ter PF15632.4 001352270.1_26229001_2 - 0.0055 15.3 0.0 0.0083 14.7 0.0 1.1 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Sep15_SelM PF08806.9 001115013.2_45722001_2 - 5e-22 77.8 0.0 7.7e-22 77.2 0.0 1.3 1 0 0 1 1 1 1 Sep15/SelM redox domain DUF947 PF06102.10 033112.3_26223001_3 - 2.1e-48 164.3 24.9 3.5e-48 163.5 24.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF947) Exonuc_VII_L PF02601.13 033112.3_26223001_3 - 1.5 8.2 8.6 1.8 7.9 8.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit PIG-P PF08510.10 001347025.1_26225001_1 - 1.4 8.7 14.5 0.03 14.1 7.5 1.7 2 0 0 2 2 2 0 PIG-P Cys_knot PF00007.20 213833.2_49825001_1 - 1.8e-16 60.2 10.6 1.8e-16 60.2 10.6 3.3 3 0 0 3 3 3 1 Cystine-knot domain VWC PF00093.16 213833.2_49825001_1 - 5.2e-10 39.4 9.4 5.2e-10 39.4 9.4 4.5 4 3 0 4 4 4 1 von Willebrand factor type C domain IGFBP PF00219.16 213833.2_49825001_1 - 1.9e-09 37.9 21.8 1.9e-09 37.9 21.8 5.0 5 2 1 6 6 6 1 Insulin-like growth factor binding protein TSP_1 PF00090.17 213833.2_49825001_1 - 2.6e-05 24.2 6.2 2.6e-05 24.2 6.2 2.6 3 0 0 3 3 3 1 Thrombospondin type 1 domain TPR_2 PF07719.15 021590.2_45724001_1 - 2.6e-10 39.5 3.9 0.00061 19.6 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat FKBP_C PF00254.26 021590.2_45724001_1 - 3.7e-06 27.0 0.0 9.7e-06 25.7 0.0 1.7 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_8 PF13181.4 021590.2_45724001_1 - 6.9e-05 22.6 0.9 0.0022 17.9 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.26 021590.2_45724001_1 - 8e-05 22.2 3.2 0.39 10.5 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.4 021590.2_45724001_1 - 0.00036 20.0 0.7 0.00036 20.0 0.7 2.2 2 0 0 2 2 2 1 TPR repeat TPR_12 PF13424.4 021590.2_45724001_1 - 0.0028 17.8 1.2 0.83 9.9 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.4 021590.2_45724001_1 - 0.0072 16.9 2.7 0.38 11.4 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.4 021590.2_45724001_1 - 0.046 14.2 2.8 7.3 7.3 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.5 021590.2_45724001_1 - 0.082 13.0 4.7 0.63 10.2 2.3 2.8 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.4 021590.2_45724001_1 - 0.1 13.3 2.4 6.8 7.7 1.2 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_21 PF09976.7 021590.2_45724001_1 - 0.15 11.7 0.9 14 5.3 0.4 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain TPR_10 PF13374.4 021590.2_45724001_1 - 0.2 11.5 4.7 1.9 8.3 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.4 021590.2_45724001_1 - 0.3 11.1 1.5 1.1 9.3 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Glyco_hydro_20 PF00728.20 213921.2_49824001_3 - 6e-89 298.8 0.0 1e-88 298.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.4 213921.2_49824001_3 - 2.7e-21 76.5 0.0 4.6e-21 75.7 0.0 1.4 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.13 213921.2_49824001_3 - 0.0039 17.9 0.0 0.0065 17.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 NCD1 PF04904.11 213921.2_49824001_3 - 0.088 12.7 0.0 0.23 11.3 0.0 1.7 1 0 0 1 1 1 0 NAB conserved region 1 (NCD1) COesterase PF00135.26 214246.2_49824001_3 - 7.8e-165 549.5 0.0 8.9e-165 549.3 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 214246.2_49824001_3 - 1.5e-10 41.2 3.0 1e-09 38.4 3.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 214246.2_49824001_3 - 0.0033 16.8 0.1 0.0054 16.1 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.18 214246.2_49824001_3 - 0.068 12.7 0.4 0.27 10.7 0.4 1.8 1 1 0 1 1 1 0 Putative esterase DUF819 PF05684.10 214246.2_49824001_3 - 0.16 10.8 0.3 0.26 10.1 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF819) Nop53 PF07767.9 207591.2_45724001_2 - 1.2e-98 330.9 22.3 1.5e-98 330.6 22.3 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) Taq-exonuc PF09281.8 207591.2_45724001_2 - 1.5 8.7 7.3 1.4 8.8 3.6 2.3 2 0 0 2 2 2 0 Taq polymerase, exonuclease DUF4081 PF13312.4 207591.2_45724001_2 - 3.4 7.8 6.9 0.29 11.2 0.2 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4081) Peptidase_C1 PF00112.21 012939.2_45723001_1 - 7.4e-79 264.7 4.2 1.4e-78 263.9 4.2 1.4 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 012939.2_45723001_1 - 1.4e-18 67.0 5.9 2.5e-18 66.1 5.9 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 012939.2_45723001_1 - 7.4e-06 24.9 0.9 0.0021 16.8 0.1 2.4 2 0 0 2 2 2 2 Peptidase C1-like family Sel1 PF08238.10 177933.3_45729001_3 - 5.1e-56 185.7 36.0 6.5e-08 32.9 0.9 12.6 12 0 0 12 12 12 9 Sel1 repeat fn2 PF00040.17 177933.3_45729001_3 - 1.8e-17 63.2 7.1 6e-17 61.5 7.1 2.0 1 0 0 1 1 1 1 Fibronectin type II domain FtsX PF02687.19 177933.3_45729001_3 - 0.69 9.8 4.2 0.59 10.0 1.9 2.0 2 0 0 2 2 2 0 FtsX-like permease family YchF-GTPase_C PF06071.11 001011708.2_26229001_2 - 2.8e-41 139.4 0.5 4.8e-41 138.7 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.21 001011708.2_26229001_2 - 2.4e-14 53.3 0.0 4.9e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.19 001011708.2_26229001_2 - 0.016 15.2 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 TGS domain Paralemmin PF03285.13 130829.2_45726001_1 - 4.1e-120 401.0 9.2 4.1e-120 401.0 9.2 1.6 2 0 0 2 2 2 1 Paralemmin IncA PF04156.12 130829.2_45726001_1 - 9.9 5.8 10.5 18 4.9 10.5 1.3 1 0 0 1 1 1 0 IncA protein PTPLA PF04387.12 001329786.1_26229001_2 - 1.2e-51 174.6 11.5 1.8e-51 174.0 11.5 1.2 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA DHHA1 PF02272.17 001329786.1_26229001_3 - 8.9 6.3 7.3 15 5.5 7.3 1.3 1 0 0 1 1 1 0 DHHA1 domain DUF676 PF05057.12 001351600.1_26229001_1 - 3.3e-61 206.5 0.0 5.9e-61 205.6 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF3657 PF12394.6 001351600.1_26229001_1 - 4.6e-18 65.4 3.2 9.4e-18 64.4 1.3 2.8 2 0 0 2 2 2 1 Protein FAM135 PGAP1 PF07819.11 001351600.1_26229001_1 - 3.1e-05 23.7 0.0 7.5e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 PGAP1-like protein LCAT PF02450.13 001351600.1_26229001_1 - 0.0011 18.1 0.1 0.0024 17.0 0.1 1.5 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase FAM176 PF14851.4 001351600.1_26229001_1 - 0.066 12.8 3.3 0.21 11.1 3.3 1.9 1 0 0 1 1 1 0 FAM176 family WD40 PF00400.30 001346382.1_26226001_2 - 0.00014 22.4 5.4 0.16 12.8 0.1 4.5 4 0 0 4 4 4 2 WD domain, G-beta repeat MDM1 PF15501.4 001354971.1_26227001_2 - 2.6e-71 241.4 8.6 3.3e-71 241.0 8.6 1.1 1 0 0 1 1 1 1 Nuclear protein MDM1 MDM1 PF15501.4 001354971.1_26227001_3 - 1.6e-120 403.8 12.8 2.9e-120 402.9 12.8 1.4 1 0 0 1 1 1 1 Nuclear protein MDM1 7tm_1 PF00001.19 001346197.1_26225001_1 - 1.9e-34 119.0 32.0 4.1e-34 117.9 32.0 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Abhydrolase_9_N PF15420.4 001346197.1_26225001_1 - 0.38 10.6 1.6 0.62 9.9 1.6 1.2 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus CHORD PF04968.10 001303277.2_26223001_1 - 1.8e-24 86.1 3.2 5.6e-24 84.5 1.6 2.3 2 0 0 2 2 2 1 CHORD CS PF04969.14 001303277.2_26223001_1 - 3.9e-12 46.9 0.1 6e-12 46.3 0.1 1.3 1 0 0 1 1 1 1 CS domain CHORD PF04968.10 001303277.2_26223001_2 - 0.041 14.5 0.1 0.067 13.8 0.1 1.3 1 0 0 1 1 1 0 CHORD zf-C2H2_6 PF13912.4 001191786.2_45729001_1 - 1.1 9.1 6.2 1.5 8.7 0.6 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger BCLP PF12304.6 033504.3_26223001_2 - 1.4e-67 226.6 9.9 1.8e-67 226.3 9.9 1.1 1 0 0 1 1 1 1 Beta-casein like protein E1-E2_ATPase PF00122.18 033504.3_26223001_2 - 4.9 6.3 8.4 4 6.6 7.2 1.4 1 1 0 1 1 1 0 E1-E2 ATPase Prion PF00377.16 001110206.3_39725001_3 - 8.4e-35 119.0 2.2 1.3e-34 118.4 2.2 1.3 1 0 0 1 1 1 1 Prion/Doppel alpha-helical domain Prion_bPrPp PF11587.6 001110206.3_39725001_3 - 6.7e-17 60.9 4.0 1.4e-16 59.9 4.0 1.6 1 0 0 1 1 1 1 Major prion protein bPrPp - N terminal SNF2_N PF00176.21 001347661.1_45729001_3 - 3.1e-63 213.5 1.5 6e-63 212.5 1.5 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.22 001347661.1_45729001_3 - 4.4e-24 84.0 7.2 2.2e-12 46.5 1.3 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.29 001347661.1_45729001_3 - 2.9e-17 62.9 0.0 8e-17 61.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain BRK PF07533.14 001347661.1_45729001_3 - 7.9e-16 57.3 0.1 2.1e-15 55.9 0.1 1.8 1 0 0 1 1 1 1 BRK domain ResIII PF04851.13 001347661.1_45729001_3 - 4.6e-08 33.1 0.7 1.2e-07 31.8 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.27 001347661.1_45729001_3 - 5.5e-05 22.9 0.0 0.00013 21.6 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase CHDCT2 PF08074.9 001347661.1_45729001_3 - 0.0033 17.5 1.9 1.6 8.8 0.0 3.7 3 0 0 3 3 3 1 CHDCT2 (NUC038) domain Myb_DNA-bind_7 PF15963.3 001347661.1_45729001_3 - 0.0056 16.4 0.1 0.028 14.2 0.1 2.2 1 0 0 1 1 1 1 Myb DNA-binding like TIMP PF00965.15 012886.2_45724001_1 - 7.2e-65 218.1 7.3 9.5e-65 217.7 7.3 1.1 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase FYTT PF07078.9 027226.4_32929001_3 - 8.5e-172 570.4 18.5 1.1e-171 570.1 18.5 1.1 1 0 0 1 1 1 1 Forty-two-three protein Arm PF00514.21 001286759.1_32928001_1 - 7.5e-32 108.2 17.3 1e-07 31.6 0.1 8.0 8 1 1 9 9 9 4 Armadillo/beta-catenin-like repeat V-ATPase_H_N PF03224.12 001286759.1_32928001_1 - 0.00012 21.4 3.0 0.033 13.4 0.2 3.6 1 1 1 2 2 2 2 V-ATPase subunit H HEAT_EZ PF13513.4 001286759.1_32928001_1 - 0.00029 21.1 8.7 0.032 14.6 0.0 4.6 5 1 1 6 6 6 2 HEAT-like repeat HEAT PF02985.20 001286759.1_32928001_1 - 0.0013 18.7 0.7 1.5 9.1 0.0 3.7 3 0 0 3 3 3 2 HEAT repeat Cnd1 PF12717.5 001286759.1_32928001_1 - 0.0056 16.6 8.7 1.5 8.7 0.4 4.3 2 2 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_C PF11698.6 001286759.1_32928001_1 - 0.038 14.0 4.2 63 3.6 0.0 4.6 3 1 0 4 4 4 0 V-ATPase subunit H Nitr_red_bet_C PF14711.4 001286759.1_32928001_1 - 0.051 13.1 0.0 0.15 11.7 0.0 1.7 1 0 0 1 1 1 0 Respiratory nitrate reductase beta C-terminal Atx10homo_assoc PF09759.7 001286759.1_32928001_1 - 0.13 12.2 0.6 27 4.8 0.1 3.4 3 0 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain RasGAP PF00616.17 001356441.1_32929001_1 - 1.3e-34 119.6 0.0 2.8e-34 118.5 0.0 1.6 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase VPS9 PF02204.16 001356441.1_32929001_1 - 1.4e-28 99.0 0.1 4.3e-28 97.4 0.0 2.0 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain Y_phosphatase PF00102.25 026918.1_26229120_2 - 7.8e-80 267.7 0.3 1.1e-79 267.2 0.3 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PDZ PF00595.22 026918.1_26229120_2 - 2e-19 69.6 0.0 3.7e-19 68.7 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) DSPc PF00782.18 026918.1_26229120_2 - 4.4e-06 26.4 0.0 7.6e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.4 026918.1_26229120_2 - 0.00015 21.6 0.0 0.00032 20.6 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.4 026918.1_26229120_2 - 0.0012 18.8 0.0 0.0023 17.9 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate ALG3 PF05208.11 024535.1_45723120_3 - 1.5e-114 383.1 15.8 1.9e-114 382.7 15.8 1.0 1 0 0 1 1 1 1 ALG3 protein EpsG PF14897.4 024535.1_45723120_3 - 0.0012 18.1 15.7 0.0017 17.6 15.7 1.3 1 0 0 1 1 1 1 EpsG family Cupin_8 PF13621.4 033170.1_45723120_1 - 6.8e-32 111.1 0.0 8.9e-32 110.7 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.10 033170.1_45723120_1 - 2.8e-08 33.5 0.0 4.5e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.20 033170.1_45723120_1 - 0.022 15.1 0.0 0.037 14.3 0.0 1.3 1 0 0 1 1 1 0 JmjC domain, hydroxylase Cupin_8 PF13621.4 033170.1_45723120_2 - 0.0024 17.6 0.0 0.0036 17.0 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain COX6A PF02046.13 037674.1_45721120_1 - 1.5e-10 41.4 0.1 2.1e-10 40.9 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa DUF4347 PF14252.4 073057.1_45726120_2 - 0.0015 18.3 0.0 0.0022 17.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4347) AA_permease PF00324.19 073053.1_45729120_3 - 3.5e-151 503.9 38.4 4.2e-151 503.6 38.4 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.13 073053.1_45729120_3 - 1.2e-150 502.0 0.0 1.6e-150 501.6 0.0 1.2 1 0 0 1 1 1 1 Solute carrier family 12 AA_permease_N PF08403.8 073053.1_45729120_3 - 2e-34 116.7 0.0 6e-33 112.0 0.1 2.4 2 0 0 2 2 2 1 Amino acid permease N-terminal AA_permease_2 PF13520.4 073053.1_45729120_3 - 1.3e-21 76.8 44.7 2.1e-21 76.1 44.7 1.2 1 0 0 1 1 1 1 Amino acid permease WD40 PF00400.30 073088.1_45726120_1 - 1e-21 76.7 15.0 5.6e-05 23.7 0.7 7.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 073088.1_45726120_1 - 2.2e-06 27.8 0.0 0.38 11.0 0.0 4.7 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 073139.1_45725120_2 - 2e-10 41.0 0.2 0.00041 21.0 0.0 3.3 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 073139.1_45725120_2 - 3.2e-05 24.0 0.1 0.00075 19.6 0.1 2.3 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.30 073139.1_45725120_3 - 4.6e-10 39.8 1.2 0.011 16.5 0.0 4.0 3 0 0 3 3 3 3 WD domain, G-beta repeat WD40 PF00400.30 073140.1_45725120_1 - 0.0034 18.1 0.0 0.011 16.5 0.0 1.9 1 0 0 1 1 1 1 WD domain, G-beta repeat WD40 PF00400.30 073140.1_45725120_3 - 6.5e-16 58.3 5.1 1e-06 29.2 0.1 4.3 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 073140.1_45725120_3 - 7.8e-07 29.2 0.4 0.00076 19.6 0.2 3.3 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 073140.1_45725120_3 - 0.036 12.6 3.4 1.9 6.9 0.0 2.8 2 1 1 3 3 3 0 Nucleoporin Nup120/160 bZIP_1 PF00170.19 073441.1_45727120_3 - 3.4e-06 26.9 7.0 6.2e-06 26.1 7.0 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 073441.1_45727120_3 - 0.0041 17.0 5.2 0.011 15.6 5.1 1.7 1 1 0 1 1 1 1 Basic region leucine zipper ZapB PF06005.10 073441.1_45727120_3 - 0.0051 17.1 0.8 0.01 16.1 0.8 1.4 1 0 0 1 1 1 1 Cell division protein ZapB TSC22 PF01166.16 073441.1_45727120_3 - 0.057 13.6 0.6 0.86 9.8 1.0 2.2 1 1 1 2 2 2 0 TSC-22/dip/bun family GIT_CC PF16559.3 073441.1_45727120_3 - 0.067 13.1 0.3 0.13 12.2 0.3 1.4 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Macoilin PF09726.7 073441.1_45727120_3 - 0.073 11.5 0.2 0.11 10.9 0.2 1.1 1 0 0 1 1 1 0 Transmembrane protein DivIC PF04977.13 073441.1_45727120_3 - 0.09 12.4 0.9 0.16 11.6 0.9 1.4 1 0 0 1 1 1 0 Septum formation initiator Vps5 PF09325.8 073441.1_45727120_3 - 0.1 12.0 0.2 0.15 11.4 0.2 1.1 1 0 0 1 1 1 0 Vps5 C terminal like bZIP_1 PF00170.19 073439.1_45729120_3 - 5.9e-06 26.1 7.0 1e-05 25.4 7.0 1.3 1 0 0 1 1 1 1 bZIP transcription factor ZapB PF06005.10 073439.1_45729120_3 - 0.0093 16.3 0.8 0.017 15.4 0.8 1.3 1 0 0 1 1 1 1 Cell division protein ZapB bZIP_2 PF07716.13 073439.1_45729120_3 - 0.033 14.1 7.2 0.082 12.9 7.2 1.6 1 0 0 1 1 1 0 Basic region leucine zipper GIT_CC PF16559.3 073439.1_45729120_3 - 0.12 12.3 0.3 0.22 11.5 0.3 1.3 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor DivIC PF04977.13 073439.1_45729120_3 - 0.13 11.9 0.8 0.25 11.0 0.8 1.4 1 0 0 1 1 1 0 Septum formation initiator Macoilin PF09726.7 073439.1_45729120_3 - 0.14 10.6 0.2 0.19 10.1 0.2 1.1 1 0 0 1 1 1 0 Transmembrane protein TSC22 PF01166.16 073439.1_45729120_3 - 0.15 12.3 0.7 1.4 9.2 1.0 2.1 1 1 1 2 2 2 0 TSC-22/dip/bun family Vps5 PF09325.8 073439.1_45729120_3 - 0.17 11.3 0.2 0.26 10.7 0.2 1.1 1 0 0 1 1 1 0 Vps5 C terminal like Pkinase PF00069.23 073162.1_45723120_1 - 4.4e-29 101.5 1.8 4.5e-29 101.5 1.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.15 073162.1_45723120_1 - 2e-21 76.3 0.3 2.8e-21 75.8 0.3 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 073162.1_45723120_2 - 1.4e-20 73.7 0.0 2e-20 73.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 073162.1_45723120_2 - 6.3e-08 32.1 0.0 1.4e-07 30.9 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase zf-Tim10_DDP PF02953.13 075101.1_45722120_2 - 0.00031 20.2 1.0 0.00031 20.2 1.0 2.2 2 0 0 2 2 2 1 Tim10/DDP family zinc finger FtsX PF02687.19 073054.1_45728120_2 - 0.058 13.2 1.8 0.09 12.6 1.8 1.2 1 0 0 1 1 1 0 FtsX-like permease family P2X_receptor PF00864.17 073054.1_45728120_3 - 2.9e-146 487.1 1.4 3.5e-146 486.9 1.4 1.1 1 0 0 1 1 1 1 ATP P2X receptor CEP63 PF17045.3 045200.1_45726120_1 - 1.8e-74 250.9 30.0 2.6e-74 250.4 30.0 1.1 1 0 0 1 1 1 1 Centrosomal protein of 63 kDa DUF3584 PF12128.6 045200.1_45726120_1 - 0.0098 13.3 18.1 0.013 12.9 18.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Spc7 PF08317.9 045200.1_45726120_1 - 0.59 8.8 25.8 1.1 8.0 25.4 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.4 045200.1_45726120_1 - 1.2 8.3 12.3 2.7 7.1 12.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.13 045200.1_45726120_1 - 2.9 7.3 11.3 4.4 6.6 11.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit V_ATPase_I PF01496.17 045200.1_45726120_1 - 3.6 5.2 10.5 5.3 4.7 10.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TPR_MLP1_2 PF07926.10 045200.1_45726120_1 - 6.8 6.6 30.4 8.7 6.3 2.2 2.9 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein CEP63 PF17045.3 045200.1_45726120_2 - 3.6e-30 105.6 14.7 3.6e-30 105.6 14.7 3.7 3 1 1 4 4 4 1 Centrosomal protein of 63 kDa DUF1043 PF06295.10 045200.1_45726120_2 - 0.0046 16.8 5.1 0.0046 16.8 5.1 4.5 4 1 2 6 6 6 1 Protein of unknown function (DUF1043) DUF1843 PF08898.8 045200.1_45726120_2 - 0.77 10.2 8.2 27 5.2 1.1 4.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1843) DUF3584 PF12128.6 045200.1_45726120_2 - 2.5 5.4 45.0 4.7 4.5 45.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Reo_sigmaC PF04582.10 045200.1_45726120_2 - 2.6 7.2 20.2 0.19 11.0 3.8 3.4 1 1 2 4 4 4 0 Reovirus sigma C capsid protein WD40 PF00400.30 073087.1_45726120_1 - 2.7e-21 75.3 16.3 5.8e-05 23.6 0.7 7.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 073087.1_45726120_1 - 5.7e-07 29.6 0.1 0.39 10.9 0.0 5.2 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain bZIP_1 PF00170.19 073440.1_45729120_3 - 5.9e-06 26.2 7.0 9.9e-06 25.4 7.0 1.3 1 0 0 1 1 1 1 bZIP transcription factor ZapB PF06005.10 073440.1_45729120_3 - 0.0088 16.3 0.8 0.017 15.4 0.8 1.3 1 0 0 1 1 1 1 Cell division protein ZapB bZIP_2 PF07716.13 073440.1_45729120_3 - 0.036 14.0 7.2 0.082 12.9 7.2 1.6 1 0 0 1 1 1 0 Basic region leucine zipper GIT_CC PF16559.3 073440.1_45729120_3 - 0.11 12.4 0.3 0.21 11.5 0.3 1.3 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Macoilin PF09726.7 073440.1_45729120_3 - 0.12 10.7 0.2 0.18 10.2 0.2 1.1 1 0 0 1 1 1 0 Transmembrane protein TSC22 PF01166.16 073440.1_45729120_3 - 0.14 12.4 0.7 1.3 9.2 1.0 2.1 1 1 1 2 2 2 0 TSC-22/dip/bun family DivIC PF04977.13 073440.1_45729120_3 - 0.14 11.8 0.9 0.26 11.0 0.9 1.4 1 0 0 1 1 1 0 Septum formation initiator Vps5 PF09325.8 073440.1_45729120_3 - 0.17 11.3 0.2 0.25 10.7 0.2 1.1 1 0 0 1 1 1 0 Vps5 C terminal like SMN PF06003.10 051995.1_45725120_2 - 0.011 14.9 0.5 0.011 14.9 0.5 2.2 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) SMN PF06003.10 051995.1_45725120_3 - 0.00018 20.8 0.0 0.00018 20.8 0.0 1.7 2 0 0 2 2 2 1 Survival motor neuron protein (SMN) DUF3591 PF12157.6 104392.1_26229120_2 - 4.6e-165 549.4 0.0 2e-164 547.3 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3591) Bromodomain PF00439.23 104392.1_26229120_2 - 2.9e-39 132.9 4.1 4.2e-19 68.3 0.5 2.6 2 0 0 2 2 2 2 Bromodomain TBP-binding PF09247.9 104392.1_26229120_2 - 1.7e-21 76.1 1.9 4.3e-21 74.8 1.9 1.7 1 0 0 1 1 1 1 TATA box-binding protein binding zf-CCHC_6 PF15288.4 104392.1_26229120_2 - 1.8e-15 56.3 0.3 4.7e-15 55.0 0.3 1.7 1 0 0 1 1 1 1 Zinc knuckle Opi1 PF08618.8 104392.1_26229120_2 - 0.035 13.2 0.8 0.064 12.4 0.8 1.3 1 0 0 1 1 1 0 Transcription factor Opi1 TFIIS_C PF01096.16 109902.1_26225120_2 - 1.1e-18 66.6 8.0 2.2e-18 65.7 8.0 1.5 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) TFIIS_M PF07500.12 109902.1_26225120_2 - 0.0034 17.7 1.7 0.0055 17.1 1.7 1.2 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain TFIID-18kDa PF02269.14 130639.1_45723120_3 - 2.7e-16 59.2 0.7 4.8e-16 58.4 0.7 1.4 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit APG6 PF04111.10 130647.1_45722120_3 - 0.00051 19.4 8.4 0.00068 19.0 8.4 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 CCDC154 PF15450.4 130647.1_45722120_3 - 0.0075 14.8 5.8 0.0092 14.5 5.8 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 154 DUF1043 PF06295.10 130647.1_45722120_3 - 0.026 14.4 2.2 0.037 13.9 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) DUF3086 PF11285.6 130647.1_45722120_3 - 0.043 12.8 2.1 0.053 12.5 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3086) Laminin_I PF06008.12 130647.1_45722120_3 - 0.055 13.0 8.5 0.076 12.6 8.5 1.1 1 0 0 1 1 1 0 Laminin Domain I HALZ PF02183.16 130647.1_45722120_3 - 0.082 13.0 4.0 0.12 12.4 3.4 1.6 1 1 0 1 1 1 0 Homeobox associated leucine zipper ADIP PF11559.6 130647.1_45722120_3 - 0.1 12.5 8.7 0.15 12.0 8.7 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Seryl_tRNA_N PF02403.20 130647.1_45722120_3 - 0.11 12.5 6.6 0.18 11.9 6.6 1.2 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF724 PF05266.12 130647.1_45722120_3 - 0.13 12.0 6.5 0.18 11.5 6.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF3450 PF11932.6 130647.1_45722120_3 - 0.24 10.5 6.8 0.31 10.2 6.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) GrpE PF01025.17 130647.1_45722120_3 - 0.33 10.5 6.6 0.47 10.0 6.6 1.1 1 0 0 1 1 1 0 GrpE CREPT PF16566.3 130647.1_45722120_3 - 0.81 9.7 6.9 1.2 9.2 6.9 1.2 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour DUF3584 PF12128.6 130647.1_45722120_3 - 1.1 6.5 9.6 1.4 6.2 9.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Mnd1 PF03962.13 130647.1_45722120_3 - 1.3 8.7 7.5 1.9 8.2 7.5 1.2 1 0 0 1 1 1 0 Mnd1 family TMPIT PF07851.11 130647.1_45722120_3 - 2.8 7.0 4.0 3.8 6.5 4.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein Spc24 PF08286.9 130647.1_45722120_3 - 3.7 7.7 6.7 6.3 7.0 6.6 1.5 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 CENP-H PF05837.10 130647.1_45722120_3 - 7.6 6.9 10.3 15 5.9 10.1 1.5 1 1 0 1 1 1 0 Centromere protein H (CENP-H) Ribosomal_S4 PF00163.17 132728.1_45722120_3 - 1.1e-05 26.1 0.1 2e-05 25.4 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.23 132728.1_45722120_3 - 1.2e-05 24.7 1.3 2.9e-05 23.5 1.3 1.7 1 0 0 1 1 1 1 S4 domain Agouti PF05039.10 131764.1_45722120_2 - 2.9e-27 95.1 15.7 4.6e-27 94.4 15.7 1.3 1 0 0 1 1 1 1 Agouti protein Toxin_9 PF02819.13 131764.1_45722120_2 - 0.029 14.5 14.6 0.029 14.5 14.6 1.9 2 0 0 2 2 2 0 Spider toxin Smg4_UPF3 PF03467.13 148484.1_26224120_1 - 2.7e-09 37.2 0.0 4.1e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Smg-4/UPF3 family DUF3498 PF12004.6 144519.1_45729120_3 - 9.6e-176 585.9 10.2 1.9e-175 584.9 10.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3498) RasGAP PF00616.17 144519.1_45729120_3 - 8.5e-27 94.1 4.1 2.1e-14 53.6 0.0 3.0 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.28 144519.1_45729120_3 - 7.2e-08 32.5 0.0 1.4e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 C2 domain PH PF00169.27 144519.1_45729120_3 - 0.00019 21.8 0.0 0.085 13.2 0.1 2.5 2 0 0 2 2 2 1 PH domain PH_2 PF08458.8 144519.1_45729120_3 - 0.044 14.0 0.0 0.084 13.1 0.0 1.3 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PH_6 PF15406.4 144519.1_45729120_3 - 0.19 11.9 0.0 0.43 10.8 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain Exonuc_VII_L PF02601.13 144519.1_45729120_3 - 0.36 10.2 8.1 0.65 9.4 8.1 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit FliD_C PF07195.10 144519.1_45729120_3 - 3.9 6.7 5.6 2.3 7.5 3.0 1.9 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Spc7 PF08317.9 144519.1_45729120_3 - 4.9 5.8 15.0 11 4.7 15.0 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein V_ATPase_I PF01496.17 144519.1_45729120_3 - 6.1 4.5 6.6 9 3.9 6.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family IncA PF04156.12 144519.1_45729120_3 - 7.3 6.2 11.5 18 4.9 11.5 1.6 1 0 0 1 1 1 0 IncA protein mTERF PF02536.12 138464.1_26227120_3 - 4.9e-11 42.0 1.1 7.7e-11 41.4 1.1 1.2 1 0 0 1 1 1 1 mTERF Lge1 PF11488.6 138253.1_45724120_2 - 7.3e-14 52.0 0.7 1.4e-13 51.1 0.7 1.3 1 0 0 1 1 1 1 Transcriptional regulatory protein LGE1 Spt4 PF06093.11 149757.1_32922120_2 - 6.4e-16 58.1 2.9 1.1e-15 57.4 2.9 1.3 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Spt4 PF06093.11 149757.1_32922120_3 - 3.6e-08 33.3 0.1 3.6e-08 33.3 0.1 1.7 2 0 0 2 2 2 1 Spt4/RpoE2 zinc finger PDZ PF00595.22 136887.1_26229120_2 - 2.3e-19 69.4 0.4 3.7e-19 68.7 0.4 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 136887.1_26229120_2 - 0.015 15.4 0.0 0.028 14.6 0.0 1.3 1 0 0 1 1 1 0 PDZ domain 7TMR-HDED PF07697.9 136887.1_26229120_2 - 1.2 9.0 6.2 1.9 8.4 6.2 1.2 1 0 0 1 1 1 0 7TM-HD extracellular RHINO PF15319.4 027367.1_45723120_1 - 2.3e-93 312.7 13.7 2.8e-93 312.4 13.7 1.1 1 0 0 1 1 1 1 RAD9, RAD1, HUS1-interacting nuclear orphan protein Geminin PF07412.10 027367.1_45723120_1 - 0.032 13.8 0.0 0.057 13.0 0.0 1.3 1 0 0 1 1 1 0 Geminin RHINO PF15319.4 027366.1_45724120_3 - 4.6e-93 311.7 13.7 5.8e-93 311.4 13.7 1.1 1 0 0 1 1 1 1 RAD9, RAD1, HUS1-interacting nuclear orphan protein Geminin PF07412.10 027366.1_45724120_3 - 0.048 13.3 0.0 0.083 12.5 0.0 1.2 1 0 0 1 1 1 0 Geminin Transmemb_17 PF09799.7 045203.1_45725120_2 - 5.2e-10 39.7 2.1 5.2e-10 39.7 2.1 2.9 2 1 1 3 3 3 2 Predicted membrane protein Transmemb_17 PF09799.7 045202.1_45725120_2 - 3.2e-28 98.3 14.6 3.2e-28 98.3 14.6 1.9 2 0 0 2 2 2 1 Predicted membrane protein Ig_3 PF13927.4 045097.1_45724120_2 - 1.4e-23 83.1 4.0 1.1e-11 45.1 0.2 3.4 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.4 045097.1_45724120_2 - 5.1e-23 81.1 1.1 2.6e-11 43.6 0.2 3.6 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 045097.1_45724120_2 - 1.5e-19 69.7 0.4 7.7e-10 38.6 0.0 3.7 3 1 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.23 045097.1_45724120_2 - 9.7e-15 54.4 6.2 1.8e-09 37.5 0.5 3.7 3 1 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 045097.1_45724120_2 - 9.6e-10 38.5 0.1 0.00078 19.4 0.0 3.3 2 1 1 3 3 3 2 Immunoglobulin V-set domain Ig_4 PF16680.3 045097.1_45724120_2 - 0.0033 17.6 0.2 1.7 9.0 0.0 3.0 3 0 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.3 045097.1_45724120_2 - 0.054 13.4 0.0 0.94 9.4 0.0 2.4 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain Adeno_E3_CR1 PF02440.13 045097.1_45724120_2 - 0.11 12.2 0.7 1.2 8.8 0.1 2.3 2 0 0 2 2 2 0 Adenovirus E3 region protein CR1 V-set PF07686.15 045097.1_45724120_3 - 6.9e-11 42.2 0.0 2.3e-10 40.4 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 045097.1_45724120_3 - 0.0001 22.7 0.1 0.68 10.5 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 045097.1_45724120_3 - 0.015 15.5 0.1 9.5 6.5 0.0 3.0 2 1 0 2 2 2 0 Immunoglobulin domain BAT2_N PF07001.9 111961.1_45729120_1 - 4.9e-53 180.4 12.1 4.9e-53 180.4 12.1 8.5 7 3 1 8 8 8 1 BAT2 N-terminus UL141 PF16758.3 132628.1_45724120_3 - 0.086 12.4 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Herpes-like virus membrane glycoprotein UL141 TIMELESS_C PF05029.11 001128153.1_39528001_1 - 1.3e-160 536.2 42.3 4.1e-160 534.5 9.5 2.9 2 1 1 3 3 3 2 Timeless protein C terminal region TIMELESS PF04821.12 001128153.1_39528001_1 - 2.9e-77 259.4 0.7 2.9e-77 259.4 0.7 2.9 3 0 0 3 3 3 1 Timeless protein Myc_N PF01056.16 001128153.1_39528001_1 - 0.025 14.3 0.3 0.025 14.3 0.3 3.5 3 1 0 4 4 4 0 Myc amino-terminal region PAXIP1_C PF15364.4 001128153.1_39528001_1 - 4.7 7.4 23.5 0.26 11.4 0.3 4.0 3 0 0 3 3 3 0 PAXIP1-associated-protein-1 C term PTIP binding protein PCNP PF15473.4 001356450.1_32925001_3 - 3.9e-63 212.7 6.3 5.5e-63 212.2 6.3 1.1 1 0 0 1 1 1 1 PEST, proteolytic signal-containing nuclear protein family UPAR_LY6_2 PF16975.3 027990.3_32925001_1 - 1.1e-53 179.7 17.6 1.8e-53 179.0 17.6 1.3 1 0 0 1 1 1 1 Ly6/PLAUR domain-containing protein 6, Lypd6 FAD_binding_7 PF03441.12 001129735.1_39524001_1 - 5.8e-70 234.5 0.3 1e-69 233.7 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.16 001129735.1_39524001_1 - 1.9e-44 151.4 0.0 3.4e-44 150.6 0.0 1.4 1 0 0 1 1 1 1 DNA photolyase FAD_binding_7 PF03441.12 001129736.1_39524001_1 - 2.5e-68 229.2 0.1 3.7e-68 228.7 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.16 001129736.1_39524001_1 - 5.6e-48 162.9 0.0 1.2e-47 161.8 0.0 1.5 1 0 0 1 1 1 1 DNA photolyase Peripla_BP_6 PF13458.4 001129736.1_39524001_1 - 0.006 16.2 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein Mab-21 PF03281.12 001168940.1_40424001_1 - 8.5e-81 271.4 10.2 1e-80 271.1 10.2 1.1 1 0 0 1 1 1 1 Mab-21 protein DUF21 PF01595.18 001356559.1_29629001_3 - 2.4e-34 118.4 0.9 4.1e-34 117.7 0.9 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF21 CBS PF00571.26 001356559.1_29629001_3 - 5.9e-08 32.9 0.4 0.0014 18.9 0.0 3.0 3 0 0 3 3 3 2 CBS domain cNMP_binding PF00027.27 001356559.1_29629001_3 - 0.0023 17.8 0.0 0.0079 16.1 0.0 1.9 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain VWA PF00092.26 001100741.1_45728001_2 - 2.4e-93 311.1 1.1 6.1e-31 107.9 0.1 3.1 3 0 0 3 3 3 3 von Willebrand factor type A domain Collagen PF01391.16 001100741.1_45728001_2 - 7.1e-50 166.5 214.8 2.5e-09 36.6 28.1 7.3 1 1 4 5 5 5 4 Collagen triple helix repeat (20 copies) VWA_2 PF13519.4 001100741.1_45728001_2 - 6.2e-37 126.4 0.1 4.2e-13 49.8 0.0 3.3 3 0 0 3 3 3 3 von Willebrand factor type A domain VWA_3 PF13768.4 001100741.1_45728001_2 - 0.00039 20.2 0.7 0.65 9.7 0.1 4.1 4 1 0 4 4 4 2 von Willebrand factor type A domain CH PF00307.29 001191782.1_45729001_1 - 9.7e-15 54.6 0.6 2e-14 53.5 0.1 1.9 2 0 0 2 2 1 1 Calponin homology (CH) domain AAA_14 PF13173.4 001191782.1_45729001_1 - 5.9e-06 26.2 0.0 1.7e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA PF00004.27 001191782.1_45729001_1 - 2.7e-05 24.5 0.1 8.8e-05 22.8 0.0 2.0 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 001191782.1_45729001_1 - 0.00033 20.8 0.2 0.009 16.2 0.2 2.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.4 001191782.1_45729001_1 - 0.00088 19.5 0.1 0.1 12.8 0.0 2.8 1 1 1 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.20 001191782.1_45729001_1 - 0.0012 19.0 0.0 0.0045 17.2 0.0 2.0 1 0 0 1 1 1 1 RNA helicase PhoH PF02562.14 001191782.1_45729001_1 - 0.0017 17.7 0.0 0.0038 16.6 0.0 1.5 1 0 0 1 1 1 1 PhoH-like protein CAMSAP_CH PF11971.6 001191782.1_45729001_1 - 0.0023 17.6 0.2 0.02 14.6 0.0 2.3 2 0 0 2 2 2 1 CAMSAP CH domain AAA_18 PF13238.4 001191782.1_45729001_1 - 0.0027 18.1 0.0 0.011 16.1 0.0 2.1 2 0 0 2 2 1 1 AAA domain IstB_IS21 PF01695.15 001191782.1_45729001_1 - 0.0048 16.5 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_25 PF13481.4 001191782.1_45729001_1 - 0.0075 15.7 0.0 0.047 13.1 0.0 2.1 1 1 1 2 2 2 1 AAA domain ResIII PF04851.13 001191782.1_45729001_1 - 0.0096 15.8 0.2 0.16 11.8 0.1 2.5 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit T2SSE PF00437.18 001191782.1_45729001_1 - 0.018 13.9 0.0 0.038 12.9 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Mg_chelatase PF01078.19 001191782.1_45729001_1 - 0.02 14.1 0.0 0.047 12.9 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.4 001191782.1_45729001_1 - 0.021 14.9 0.0 0.054 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.12 001191782.1_45729001_1 - 0.022 14.8 0.0 0.061 13.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_19 PF13245.4 001191782.1_45729001_1 - 0.023 14.9 0.0 0.064 13.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.12 001191782.1_45729001_1 - 0.071 13.0 0.1 0.23 11.3 0.0 1.9 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.10 001191782.1_45729001_1 - 0.091 12.5 0.1 0.24 11.2 0.0 1.8 2 0 0 2 2 1 0 NACHT domain NTPase_1 PF03266.13 001191782.1_45729001_1 - 0.19 11.5 0.2 6.1 6.6 0.1 2.4 2 0 0 2 2 2 0 NTPase DUF4201 PF13870.4 001191782.1_45729001_1 - 3.5 7.1 18.1 1.5 8.3 6.1 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) DUF1993 PF09351.8 001191782.1_45729001_1 - 5.3 7.0 7.9 0.19 11.7 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1993) KLRAQ PF10205.7 001191782.1_45729001_1 - 5.8 7.1 9.2 5.3 7.2 0.7 3.5 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein SH3_1 PF00018.26 001191782.1_45729001_3 - 0.043 13.3 1.3 0.082 12.4 1.3 1.4 1 0 0 1 1 1 0 SH3 domain Collagen PF01391.16 053488.1_45729001_1 - 4e-165 535.6 681.7 1.8e-08 33.9 34.8 20.9 2 1 12 14 14 14 11 Collagen triple helix repeat (20 copies) COLFI PF01410.16 053488.1_45729001_1 - 6.7e-105 349.4 0.1 8.6e-105 349.1 0.1 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain VWC PF00093.16 053488.1_45729001_1 - 1.3e-12 47.7 15.1 2.8e-12 46.6 15.1 1.6 1 0 0 1 1 1 1 von Willebrand factor type C domain TILa PF12714.5 053488.1_45729001_1 - 0.0081 16.0 6.9 0.021 14.6 6.9 1.7 1 0 0 1 1 1 1 TILa domain Amnionless PF14828.4 053488.1_45729001_1 - 0.7 8.6 14.5 0.99 8.0 14.5 1.1 1 0 0 1 1 1 0 Amnionless IRF-3 PF10401.7 001106586.1_45725001_3 - 2.6e-70 235.8 0.3 4e-70 235.2 0.3 1.3 1 0 0 1 1 1 1 Interferon-regulatory factor 3 IRF PF00605.15 001106586.1_45725001_3 - 2.4e-38 130.5 0.0 3.9e-38 129.8 0.0 1.3 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor Crystallin PF00525.16 012534.4_45723001_3 - 1.9e-26 91.9 2.2 4.3e-26 90.8 2.2 1.6 1 0 0 1 1 1 1 Alpha crystallin A chain, N terminal HSP20 PF00011.19 012534.4_45723001_3 - 2.5e-21 75.6 0.0 3.4e-21 75.2 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family LRR_8 PF13855.4 053385.1_45723001_1 - 2.7e-38 129.4 33.4 7.9e-14 51.0 0.1 6.8 3 2 3 7 7 7 7 Leucine rich repeat LRR_4 PF12799.5 053385.1_45723001_1 - 1.6e-23 82.1 31.3 7.9e-05 22.8 3.2 7.5 4 3 3 7 7 7 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 053385.1_45723001_1 - 1.3e-07 31.0 30.6 0.88 10.2 0.2 10.4 9 2 0 9 9 9 3 Leucine Rich Repeat LRR_9 PF14580.4 053385.1_45723001_1 - 4.8e-07 29.3 13.3 0.011 15.1 0.2 4.8 1 1 4 5 5 5 4 Leucine-rich repeat LRRNT PF01462.16 053385.1_45723001_1 - 3.2e-06 26.5 6.7 5.8e-06 25.7 4.4 2.6 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain Chromo_shadow PF01393.17 001106797.3_45723001_1 - 4.6e-30 103.3 0.9 7.4e-27 93.0 0.0 2.5 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.22 001106797.3_45723001_1 - 2.5e-19 68.8 0.8 2.8e-17 62.2 0.5 2.6 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.4 001106797.3_45723001_1 - 0.0069 16.4 0.2 0.015 15.3 0.2 1.6 1 0 0 1 1 1 1 Polycomb-like MTF2 factor 2 zf-TRAF PF02176.16 001107017.2_45725001_2 - 1.9e-45 153.2 35.9 4.6e-20 71.9 4.7 4.7 1 1 3 4 4 4 3 TRAF-type zinc finger zf-C3HC4 PF00097.23 001107017.2_45725001_2 - 1.9e-07 30.7 3.5 1.9e-07 30.7 3.5 3.6 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001107017.2_45725001_2 - 8.2e-07 28.6 5.2 8.2e-07 28.6 5.2 3.3 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001107017.2_45725001_2 - 1.1e-06 28.4 7.7 5.1e-06 26.3 7.7 2.3 1 0 0 1 1 1 1 RING-type zinc-finger zf-TRAF_2 PF15965.3 001107017.2_45725001_2 - 9.6e-05 22.6 31.9 0.35 11.2 3.3 4.9 1 1 4 5 5 5 4 TRAF-like zinc-finger zf-Nse PF11789.6 001107017.2_45725001_2 - 0.00014 21.5 2.3 0.00014 21.5 2.3 2.7 3 0 0 3 3 3 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_5 PF14634.4 001107017.2_45725001_2 - 0.00015 21.5 3.8 0.00015 21.5 3.8 3.2 3 1 0 3 3 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.4 001107017.2_45725001_2 - 0.00032 20.7 5.6 0.00032 20.7 5.6 3.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.4 001107017.2_45725001_2 - 0.00047 19.8 1.2 0.0015 18.2 1.2 1.8 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_2 PF13639.4 001107017.2_45725001_2 - 0.0005 20.1 4.5 0.0005 20.1 4.5 3.9 2 1 1 3 3 2 1 Ring finger domain zf-C3HC4_3 PF13920.4 001107017.2_45725001_2 - 0.00088 19.0 2.1 0.00088 19.0 2.1 3.3 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) Sina PF03145.14 001107017.2_45725001_2 - 0.01 15.7 2.4 0.01 15.7 2.4 4.0 1 1 5 6 6 5 0 Seven in absentia protein family zf-rbx1 PF12678.5 001107017.2_45725001_2 - 0.013 15.6 1.8 0.013 15.6 1.8 3.4 2 1 1 3 3 3 0 RING-H2 zinc finger domain MATH PF00917.24 001107017.2_45725001_2 - 0.019 14.9 0.0 1.1 9.2 0.0 2.4 1 1 1 2 2 2 0 MATH domain TIP49 PF06068.11 001025405.2_45724001_1 - 4e-184 612.0 3.1 4.8e-184 611.8 3.1 1.0 1 0 0 1 1 1 1 TIP49 C-terminus AAA PF00004.27 001025405.2_45724001_1 - 3.5e-09 37.0 0.3 1.8e-05 25.1 0.1 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 001025405.2_45724001_1 - 3.8e-07 30.5 0.1 5.3e-06 26.8 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain DnaB_C PF03796.13 001025405.2_45724001_1 - 3.1e-06 26.5 0.2 5.6e-06 25.7 0.2 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain RuvB_N PF05496.10 001025405.2_45724001_1 - 4.3e-06 26.0 0.5 0.0014 17.8 0.1 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.12 001025405.2_45724001_1 - 1.4e-05 25.0 0.1 0.0033 17.3 0.0 3.0 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.4 001025405.2_45724001_1 - 0.00012 22.2 0.4 0.16 12.1 0.0 2.4 1 1 1 2 2 2 2 AAA domain AAA_19 PF13245.4 001025405.2_45724001_1 - 0.00016 21.9 2.1 0.0016 18.7 2.1 2.4 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.24 001025405.2_45724001_1 - 0.00039 20.0 0.3 0.21 11.2 0.0 2.7 3 0 0 3 3 2 1 Sigma-54 interaction domain Mg_chelatase PF01078.19 001025405.2_45724001_1 - 0.00042 19.6 1.1 0.0083 15.4 0.3 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.4 001025405.2_45724001_1 - 0.0022 17.5 0.0 0.0098 15.4 0.1 1.9 2 0 0 2 2 2 1 AAA domain ATPase PF06745.11 001025405.2_45724001_1 - 0.0025 17.0 0.1 0.0055 16.0 0.1 1.5 1 0 0 1 1 1 1 KaiC Zeta_toxin PF06414.10 001025405.2_45724001_1 - 0.0063 15.7 0.4 0.013 14.7 0.4 1.4 1 0 0 1 1 1 1 Zeta toxin DUF2075 PF09848.7 001025405.2_45724001_1 - 0.016 14.3 0.0 0.029 13.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.4 001025405.2_45724001_1 - 0.021 14.4 1.1 1.1 8.8 0.4 2.5 2 0 0 2 2 2 0 AAA domain NACHT PF05729.10 001025405.2_45724001_1 - 0.025 14.4 0.0 0.049 13.4 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_11 PF13086.4 001025405.2_45724001_1 - 0.091 12.3 0.1 0.16 11.5 0.1 1.5 1 1 0 1 1 1 0 AAA domain MS_channel PF00924.16 001025405.2_45724001_1 - 0.092 12.1 0.0 0.23 10.9 0.0 1.6 1 0 0 1 1 1 0 Mechanosensitive ion channel PhoH PF02562.14 001025405.2_45724001_1 - 0.11 11.8 2.0 0.39 10.0 0.4 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_23 PF13476.4 001025405.2_45724001_1 - 0.11 12.8 0.4 0.21 11.9 0.4 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.4 001025405.2_45724001_1 - 0.12 11.9 0.2 0.69 9.5 0.1 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain TsaE PF02367.15 001025405.2_45724001_1 - 0.27 11.1 1.1 0.45 10.4 0.1 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PKD_channel PF08016.10 001191934.1_45729001_1 - 2.7e-168 560.0 16.6 2.7e-168 560.0 16.6 1.6 2 0 0 2 2 2 1 Polycystin cation channel Ion_trans PF00520.29 001191934.1_45729001_1 - 1.4e-23 83.2 30.2 1.4e-23 83.2 30.2 2.1 2 0 0 2 2 2 1 Ion transport protein EF-hand_1 PF00036.30 001191934.1_45729001_1 - 0.0013 18.0 1.5 0.082 12.4 0.3 3.2 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.4 001191934.1_45729001_1 - 0.048 13.5 0.5 0.32 10.9 0.1 2.5 2 0 0 2 2 2 0 EF-hand domain DUF4201 PF13870.4 001191934.1_45729001_1 - 0.059 12.9 0.3 0.12 11.9 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) EF-hand_7 PF13499.4 001191934.1_45729001_1 - 0.44 10.9 3.0 1.1 9.6 0.6 2.5 2 0 0 2 2 2 0 EF-hand domain pair Ras PF00071.20 031091.2_45723001_2 - 8.3e-60 200.9 0.3 1e-59 200.6 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 031091.2_45723001_2 - 3e-33 114.5 0.6 4.4e-33 113.9 0.6 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 031091.2_45723001_2 - 5.1e-13 48.7 0.1 7e-13 48.3 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 031091.2_45723001_2 - 0.00046 19.5 0.0 0.00099 18.5 0.0 1.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 031091.2_45723001_2 - 0.00065 19.6 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 031091.2_45723001_2 - 0.0014 17.9 0.0 0.0018 17.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 031091.2_45723001_2 - 0.0032 16.9 0.0 0.0067 15.9 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF2757 PF10955.6 031091.2_45723001_2 - 0.065 13.4 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) FeoB_N PF02421.16 031091.2_45723001_2 - 0.088 12.2 0.0 8.3 5.8 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B MRF_C2 PF13888.4 001170487.1_45729001_1 - 9e-42 142.1 0.3 1.5e-41 141.4 0.3 1.4 1 0 0 1 1 1 1 Myelin gene regulatory factor C-terminal domain 2 NDT80_PhoG PF05224.10 001170487.1_45729001_1 - 3.9e-28 98.8 0.6 1.9e-27 96.6 0.6 2.0 1 1 0 1 1 1 1 NDT80 / PhoG like DNA-binding family MRF_C1 PF13887.4 001170487.1_45729001_1 - 1.4e-22 78.4 1.0 2.4e-22 77.7 1.0 1.4 1 0 0 1 1 1 1 Myelin gene regulatory factor -C-terminal domain 1 Peptidase_S74 PF13884.4 001170487.1_45729001_1 - 5.9e-13 48.8 0.0 1e-12 48.0 0.0 1.4 1 0 0 1 1 1 1 Chaperone of endosialidase Pkinase PF00069.23 001191926.1_45726001_1 - 1.1e-43 149.4 0.0 1.8e-43 148.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ribonuc_2-5A PF06479.10 001191926.1_45726001_1 - 7.1e-41 139.2 0.2 1.3e-40 138.3 0.2 1.5 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.15 001191926.1_45726001_1 - 7.6e-25 87.5 0.0 1.3e-24 86.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PQQ_2 PF13360.4 001191926.1_45726001_1 - 1.7e-08 34.2 0.1 0.0035 16.8 0.1 2.2 2 0 0 2 2 2 2 PQQ-like domain PQQ PF01011.19 001191926.1_45726001_1 - 5.9e-06 25.8 0.6 0.13 12.1 0.0 3.8 4 0 0 4 4 4 2 PQQ enzyme repeat APH PF01636.21 001191926.1_45726001_1 - 0.00015 21.6 0.7 0.047 13.5 0.1 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.12 001191926.1_45726001_1 - 0.0002 20.7 0.2 0.00038 19.8 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PQQ_3 PF13570.4 001191926.1_45726001_1 - 1.7 9.1 3.7 12 6.4 0.0 4.1 5 2 1 6 6 6 0 PQQ-like domain NmrA PF05368.11 001191588.1_45723001_1 - 7.1e-48 163.0 0.0 9.4e-48 162.7 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.4 001191588.1_45723001_1 - 3.3e-13 49.8 0.0 4.6e-13 49.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding TrkA_N PF02254.16 001191588.1_45723001_1 - 8e-05 22.7 0.1 0.00021 21.4 0.1 1.7 2 0 0 2 2 2 1 TrkA-N domain Sacchrp_dh_NADP PF03435.16 001191588.1_45723001_1 - 0.00022 21.4 0.1 0.00067 19.8 0.0 1.8 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain KR PF08659.8 001191588.1_45723001_1 - 0.00079 19.2 0.5 0.0017 18.2 0.1 1.6 2 0 0 2 2 2 1 KR domain Epimerase PF01370.19 001191588.1_45723001_1 - 0.0031 16.9 0.1 0.005 16.2 0.1 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short PF00106.23 001191588.1_45723001_1 - 0.0036 16.7 0.4 0.0064 15.8 0.4 1.4 1 0 0 1 1 1 1 short chain dehydrogenase 3Beta_HSD PF01073.17 001191588.1_45723001_1 - 0.0098 14.8 0.0 0.014 14.3 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family F420_oxidored PF03807.15 001191588.1_45723001_1 - 0.013 15.9 0.1 0.031 14.7 0.1 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.22 001191588.1_45723001_1 - 0.032 14.5 0.1 0.16 12.3 0.0 2.0 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Shikimate_DH PF01488.18 001191588.1_45723001_1 - 0.16 11.9 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase BRK PF07533.14 001191588.1_45723001_1 - 0.17 11.4 0.3 0.48 10.0 0.3 1.7 1 0 0 1 1 1 0 BRK domain Ig_3 PF13927.4 001109076.1_45728001_3 - 1.8e-20 73.2 0.1 7.8e-08 32.7 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 001109076.1_45728001_3 - 5.7e-19 68.2 0.0 3.7e-15 55.9 0.0 3.3 4 0 0 4 4 3 2 Immunoglobulin V-set domain ig PF00047.23 001109076.1_45728001_3 - 5.3e-18 64.8 0.0 5.5e-05 23.1 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 001109076.1_45728001_3 - 3.2e-16 59.1 0.0 0.00012 22.0 0.0 3.8 3 1 0 3 3 3 3 Immunoglobulin I-set domain C2-set_2 PF08205.10 001109076.1_45728001_3 - 4.3e-16 58.6 1.2 1.3e-14 53.9 0.3 2.5 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.4 001109076.1_45728001_3 - 1.8e-11 44.1 0.1 4.7e-05 23.5 0.0 3.8 3 1 0 3 3 3 2 Immunoglobulin domain DUF1191 PF06697.10 001109076.1_45728001_3 - 0.0039 16.3 0.1 0.0067 15.6 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1191) EphA2_TM PF14575.4 001109076.1_45728001_3 - 0.037 14.7 0.1 0.11 13.2 0.0 1.8 2 0 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain Protocadherin PF08374.9 001109076.1_45728001_3 - 0.041 13.7 0.0 0.069 13.0 0.0 1.2 1 0 0 1 1 1 0 Protocadherin TMEM154 PF15102.4 001109076.1_45728001_3 - 0.1 12.4 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family Chordopox_A13L PF05961.9 001109076.1_45728001_3 - 0.1 12.7 0.0 0.1 12.7 0.0 1.8 2 0 0 2 2 2 0 Chordopoxvirus A13L protein ABC_membrane_3 PF13748.4 001109076.1_45728001_3 - 0.1 11.7 0.4 0.17 11.0 0.4 1.2 1 0 0 1 1 1 0 ABC transporter transmembrane region DUF4692 PF15763.3 001109076.1_45728001_3 - 0.11 12.8 0.2 0.19 12.1 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4692) DAZAP2 PF11029.6 001013107.1_45724001_1 - 1.2e-39 136.0 7.6 1.9e-39 135.4 7.6 1.2 1 0 0 1 1 1 1 DAZ associated protein 2 (DAZAP2) Laminin_EGF PF00053.22 053966.2_45729001_2 - 4e-85 279.7 237.6 2.2e-11 43.6 13.9 13.4 14 0 0 14 14 14 12 Laminin EGF domain Laminin_N PF00055.15 053966.2_45729001_2 - 1.1e-82 277.0 0.0 4.5e-82 275.0 0.0 2.2 1 0 0 1 1 1 1 Laminin N-terminal (Domain VI) Laminin_B PF00052.16 053966.2_45729001_2 - 1.2e-31 109.2 0.0 2.5e-31 108.2 0.0 1.6 1 0 0 1 1 1 1 Laminin B (Domain IV) LOH1CR12 PF10158.7 053966.2_45729001_2 - 2.5 8.0 9.5 0.13 12.2 0.8 3.1 2 2 2 4 4 4 0 Tumour suppressor protein Ig_3 PF13927.4 001106813.1_45724001_1 - 4.2e-11 43.2 8.1 1.2e-05 25.6 0.0 3.6 4 0 0 4 4 3 2 Immunoglobulin domain ig PF00047.23 001106813.1_45724001_1 - 4.6e-09 36.2 6.3 2.4e-05 24.3 0.3 3.6 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.10 001106813.1_45724001_1 - 6.6e-09 35.6 7.9 6.6e-08 32.4 0.7 3.1 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain V-set PF07686.15 001106813.1_45724001_1 - 1.6e-08 34.5 5.6 6.1e-08 32.7 0.4 2.9 3 0 0 3 3 3 1 Immunoglobulin V-set domain I-set PF07679.14 001106813.1_45724001_1 - 1.3e-07 31.5 0.1 0.00015 21.6 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 001106813.1_45724001_1 - 4.3e-07 30.0 2.9 0.00064 19.9 0.2 3.0 3 0 0 3 3 3 2 Immunoglobulin domain DUF4834 PF16118.3 001106813.1_45724001_1 - 0.0029 18.4 0.7 0.0029 18.4 0.7 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) Herpes_gE PF02480.14 001106813.1_45724001_1 - 0.0043 15.7 0.0 0.22 10.1 0.0 2.1 2 0 0 2 2 2 1 Alphaherpesvirus glycoprotein E DUF1510 PF07423.9 001106813.1_45724001_1 - 0.0086 15.4 0.1 0.0086 15.4 0.1 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF1510) SID-1_RNA_chan PF13965.4 001106813.1_45724001_1 - 0.068 11.5 2.4 0.095 11.0 1.8 1.4 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 Nucleoside_tran PF01733.16 001106813.1_45724001_1 - 0.083 12.1 0.2 0.14 11.4 0.2 1.2 1 0 0 1 1 1 0 Nucleoside transporter DUF912 PF06024.10 001106813.1_45724001_1 - 0.086 13.0 3.2 0.12 12.5 0.1 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) SoxG PF04268.10 001106813.1_45724001_1 - 0.097 12.7 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Sarcosine oxidase, gamma subunit family YAF2_RYBP PF17219.1 001106813.1_45724001_1 - 0.49 9.8 4.0 13 5.3 0.2 2.5 2 0 0 2 2 2 0 Yaf2/RYBP C-terminal binding motif TMEM154 PF15102.4 001106813.1_45724001_1 - 1.9 8.3 9.8 0.084 12.6 2.2 2.3 2 1 0 2 2 2 0 TMEM154 protein family zf-H2C2_2 PF13465.4 001243869.1_39724001_1 - 2e-124 400.8 120.1 9.1e-09 35.3 0.5 17.8 18 0 0 18 18 18 16 Zinc-finger double domain zf-C2H2 PF00096.24 001243869.1_39724001_1 - 7.8e-78 252.7 118.6 1.7e-05 24.9 0.3 16.9 17 0 0 17 17 16 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001243869.1_39724001_1 - 4.2e-48 157.7 117.0 0.0019 18.7 0.4 17.2 17 0 0 17 17 17 16 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001243869.1_39724001_1 - 1.2e-20 72.8 81.3 9.7e-05 21.9 0.2 16.2 17 0 0 17 17 17 7 zinc-finger C2H2-type zf-C2H2_6 PF13912.4 001243869.1_39724001_1 - 1.2e-17 63.2 96.3 0.11 12.3 0.1 16.8 16 0 0 16 16 16 12 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001243869.1_39724001_1 - 4.4e-16 58.6 86.1 0.012 15.6 3.3 11.1 2 1 13 15 15 15 14 Zinc ribbon domain C1_4 PF07975.10 001243869.1_39724001_1 - 6.5e-07 29.4 80.1 0.073 13.2 0.2 11.7 2 1 9 13 13 13 5 TFIIH C1-like domain zinc_ribbon_15 PF17032.3 001243869.1_39724001_1 - 1.2e-06 29.0 71.2 0.52 11.0 2.5 9.1 1 1 8 9 9 9 7 zinc-ribbon family DUF3741 PF12552.6 001243869.1_39724001_1 - 0.00014 21.6 2.0 30 4.5 0.0 8.0 10 0 0 10 10 10 0 Protein of unknown function (DUF3741) Rapsyn_N PF10579.7 001243869.1_39724001_1 - 0.0011 18.9 0.0 7.4 6.6 0.0 5.7 5 2 3 8 8 8 1 Rapsyn N-terminal myristoylation and linker region CpXC PF14353.4 001243869.1_39724001_1 - 0.0011 18.8 65.5 4.7 7.1 0.1 15.2 2 2 11 14 14 14 2 CpXC protein XPA_N PF01286.16 001243869.1_39724001_1 - 0.0068 16.3 85.2 9.5 6.2 0.2 16.2 16 0 0 16 16 16 1 XPA protein N-terminal zf-trcl PF13451.4 001243869.1_39724001_1 - 0.0083 15.9 75.2 6.5 6.6 0.1 15.7 15 1 0 15 15 15 1 Probable zinc-ribbon domain KRAB PF01352.25 001243869.1_39724001_1 - 0.099 12.2 0.2 0.19 11.3 0.2 1.5 1 0 0 1 1 1 0 KRAB box DUF4389 PF14333.4 001243869.1_39724001_1 - 0.14 12.0 0.0 15 5.5 0.0 3.7 4 0 0 4 4 3 0 Domain of unknown function (DUF4389) Zn_Tnp_IS1595 PF12760.5 001243869.1_39724001_1 - 0.19 11.6 99.9 0.05 13.5 1.4 14.0 9 5 6 15 15 15 0 Transposase zinc-ribbon domain zf-C2H2_jaz PF12171.6 001243869.1_39724001_1 - 0.27 11.5 81.4 0.31 11.3 0.3 15.0 16 0 0 16 16 16 0 Zinc-finger double-stranded RNA-binding Mucin2_WxxW PF13330.4 001108161.1_45729001_1 - 5.5e-20 71.8 0.0 5.5e-20 71.8 0.0 3.3 4 0 0 4 4 4 1 Mucin-2 protein WxxW repeating region Ig_3 PF13927.4 001108161.1_45729001_1 - 8.8e-14 51.8 0.1 2.2e-13 50.5 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001108161.1_45729001_1 - 1.7e-10 41.0 0.1 3.8e-10 39.8 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain CarboxypepD_reg PF13620.4 001108161.1_45729001_1 - 2.8e-09 37.0 0.1 3.7e-06 27.0 0.0 3.0 3 0 0 3 3 3 2 Carboxypeptidase regulatory-like domain TSP_1 PF00090.17 001108161.1_45729001_1 - 1.5e-08 34.6 11.1 1.5e-08 34.6 11.1 3.1 3 0 0 3 3 3 1 Thrombospondin type 1 domain I-set PF07679.14 001108161.1_45729001_1 - 4.1e-08 33.0 0.0 9.9e-08 31.8 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin I-set domain CarbopepD_reg_2 PF13715.4 001108161.1_45729001_1 - 5.7e-08 32.5 0.0 0.0083 16.0 0.0 2.5 2 0 0 2 2 2 2 CarboxypepD_reg-like domain ig PF00047.23 001108161.1_45729001_1 - 1.5e-06 28.1 0.0 4.5e-06 26.6 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 001108161.1_45729001_1 - 0.00052 20.0 0.5 0.032 14.2 0.0 2.6 1 1 1 2 2 2 1 Immunoglobulin V-set domain BIR PF00653.19 021752.2_45726001_1 - 1.6e-64 214.4 8.1 1.1e-20 74.0 0.0 3.9 3 0 0 3 3 3 3 Inhibitor of Apoptosis domain CARD PF00619.19 021752.2_45726001_1 - 5.5e-23 80.7 0.6 1.2e-22 79.6 0.6 1.6 1 0 0 1 1 1 1 Caspase recruitment domain zf-C3HC4_3 PF13920.4 021752.2_45726001_1 - 2.5e-14 52.7 8.3 2.5e-14 52.7 8.3 2.7 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 021752.2_45726001_1 - 1.5e-07 31.0 7.6 3.8e-07 29.7 7.6 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.4 021752.2_45726001_1 - 0.0056 16.4 6.9 0.026 14.3 6.9 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF2039 PF10217.7 021752.2_45726001_1 - 0.25 11.6 3.5 0.57 10.4 3.5 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) EGF_CA PF07645.13 031825.1_45729001_1 - 0 1060.4 704.9 3.9e-11 42.8 10.1 48.2 48 0 0 48 48 48 44 Calcium-binding EGF domain cEGF PF12662.5 031825.1_45729001_1 - 2.1e-217 702.0 427.3 3.5e-10 39.5 0.9 50.2 49 0 0 49 49 49 43 Complement Clr-like EGF-like FXa_inhibition PF14670.4 031825.1_45729001_1 - 2.4e-106 347.6 707.6 1.1e-10 41.5 8.2 49.1 42 6 6 48 48 48 43 Coagulation Factor Xa inhibitory site EGF PF00008.25 031825.1_45729001_1 - 1.4e-103 338.4 700.8 0.0001 22.4 6.5 50.0 50 0 0 50 50 50 43 EGF-like domain TB PF00683.15 031825.1_45729001_1 - 4.8e-102 333.3 125.0 8.7e-14 50.8 5.4 11.4 9 0 0 9 9 9 9 TB domain hEGF PF12661.5 031825.1_45729001_1 - 3e-97 316.2 649.0 6.5e-05 23.3 3.5 51.9 50 0 0 50 50 50 42 Human growth factor-like EGF EGF_3 PF12947.5 031825.1_45729001_1 - 2.3e-56 187.5 609.4 8.1e-10 38.6 12.8 48.9 48 1 1 49 49 49 39 EGF domain Plasmod_Pvs28 PF06247.9 031825.1_45729001_1 - 4.1e-10 39.7 551.7 0.0015 18.6 6.5 45.6 45 1 1 46 46 46 29 Pvs28 EGF domain Polyoma_agno PF01736.14 031825.1_45729001_2 - 0.16 11.6 1.5 0.24 11.0 0.2 2.0 2 0 0 2 2 2 0 Polyomavirus agnoprotein S_100 PF01023.17 012618.2_45721001_2 - 2.3e-19 68.7 0.3 2.3e-19 68.7 0.3 1.8 2 0 0 2 2 2 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 012618.2_45721001_2 - 1.5e-06 28.4 0.4 2.4e-06 27.8 0.4 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 012618.2_45721001_2 - 0.0003 20.0 0.7 0.0024 17.2 0.1 2.3 2 0 0 2 2 2 1 EF hand EF-hand_4 PF12763.5 012618.2_45721001_2 - 0.0034 17.2 0.0 0.0044 16.8 0.0 1.2 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_8 PF13833.4 012618.2_45721001_2 - 0.0053 16.4 0.1 0.011 15.3 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair Campylo_MOMP PF05538.9 012618.2_45721001_2 - 0.0053 15.7 0.0 0.0073 15.3 0.0 1.2 1 0 0 1 1 1 1 Campylobacter major outer membrane protein EF-hand_6 PF13405.4 012618.2_45721001_2 - 0.01 15.6 0.1 0.86 9.6 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.4 012618.2_45721001_2 - 0.045 13.2 0.8 0.25 10.8 0.1 2.2 2 0 0 2 2 2 0 EF hand Ion_trans PF00520.29 012972.1_45724001_1 - 1.2e-51 175.2 0.5 1.6e-51 174.8 0.5 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 012972.1_45724001_1 - 3.6e-27 94.4 0.0 6.4e-27 93.6 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 012972.1_45724001_1 - 8.2e-14 51.2 5.1 8.2e-14 51.2 5.1 2.3 3 0 0 3 3 3 1 Ion channel PKD_channel PF08016.10 012972.1_45724001_1 - 0.00022 19.9 1.6 0.0004 19.1 1.6 1.3 1 0 0 1 1 1 1 Polycystin cation channel Laminin_G_2 PF02210.22 130773.3_26229001_2 - 3.9e-90 298.8 5.6 1e-24 87.4 0.2 4.3 4 0 0 4 4 4 4 Laminin G domain Laminin_G_1 PF00054.21 130773.3_26229001_2 - 1e-61 206.7 0.2 4.1e-15 56.0 0.0 4.3 4 0 0 4 4 4 4 Laminin G domain F5_F8_type_C PF00754.23 130773.3_26229001_2 - 6e-29 100.6 2.9 1.1e-28 99.7 1.5 2.2 2 0 0 2 2 2 1 F5/8 type C domain Laminin_G_3 PF13385.4 130773.3_26229001_2 - 1.2e-08 35.1 0.0 0.0025 17.8 0.0 5.0 5 0 0 5 5 5 1 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.25 130773.3_26229001_2 - 0.00068 19.7 26.0 0.0019 18.3 9.7 3.3 3 0 0 3 3 3 2 EGF-like domain EGF_2 PF07974.11 130773.3_26229001_2 - 0.0085 16.3 11.3 0.0085 16.3 11.3 3.7 3 0 0 3 3 3 1 EGF-like domain NTF2 PF02136.18 001205405.1_49826001_3 - 8.3e-32 110.1 0.4 1.4e-31 109.4 0.4 1.4 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.20 001205405.1_49826001_3 - 1.2e-12 47.3 0.1 2.3e-12 46.4 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001205405.1_49826001_3 - 0.0026 17.7 0.0 0.0081 16.1 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif zf-A20 PF01754.14 001007630.1_45724001_2 - 2.7e-12 46.2 8.8 7.9e-12 44.8 8.8 1.9 1 0 0 1 1 1 1 A20-like zinc finger zf-AN1 PF01428.14 001007630.1_45724001_2 - 5.9e-09 35.8 7.7 5.9e-09 35.8 7.7 2.9 2 0 0 2 2 2 1 AN1-like Zinc finger zf-C2H2 PF00096.24 001317940.1_26229001_2 - 6.5e-07 29.3 32.8 0.018 15.4 1.8 7.4 6 0 0 6 6 6 3 Zinc finger, C2H2 type zf-met PF12874.5 001317940.1_26229001_2 - 0.0002 21.5 22.0 0.027 14.7 0.1 5.6 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 001317940.1_26229001_2 - 0.021 15.0 16.5 1.7 8.9 1.5 4.5 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding AA_permease_2 PF13520.4 013111.3_45729001_1 - 8.1e-48 163.2 23.0 8.1e-48 163.2 23.0 2.5 3 0 0 3 3 3 1 Amino acid permease AA_permease PF00324.19 013111.3_45729001_1 - 1.1e-38 132.9 22.4 1.1e-38 132.9 22.4 2.1 2 0 0 2 2 2 1 Amino acid permease AA_permease_C PF13906.4 013111.3_45729001_1 - 5.2e-25 87.1 6.7 5.2e-25 87.1 6.7 2.8 3 0 0 3 3 3 1 C-terminus of AA_permease OST3_OST6 PF04756.11 013111.3_45729001_1 - 0.21 10.8 4.6 0.84 8.8 0.4 2.9 3 0 0 3 3 3 0 OST3 / OST6 family, transporter family GSHPx PF00255.17 001285712.2_09022001_3 - 3.5e-41 139.0 0.0 4.7e-41 138.6 0.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.19 001285712.2_09022001_3 - 0.0015 18.3 0.0 0.028 14.2 0.0 2.2 1 1 0 1 1 1 1 AhpC/TSA family DUF1590 PF07629.9 001285712.2_09022001_3 - 0.034 13.8 0.2 0.072 12.8 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1590) 6PF2K PF01591.16 001177754.1_32929001_1 - 1.2e-106 354.9 0.2 1.7e-106 354.4 0.2 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.20 001177754.1_32929001_1 - 1.5e-39 135.6 0.0 2.1e-39 135.1 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.4 001177754.1_32929001_1 - 7.7e-07 29.2 0.0 1.3e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.8 001177754.1_32929001_1 - 8.9e-05 21.9 0.1 0.00014 21.2 0.1 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Pkinase PF00069.23 012727.3_45724001_1 - 4.2e-78 262.2 0.0 6.7e-78 261.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 012727.3_45724001_1 - 1.2e-29 103.2 0.0 1.9e-29 102.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 012727.3_45724001_1 - 2.2e-05 23.8 0.0 8.3e-05 21.9 0.0 1.8 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.4 012727.3_45724001_1 - 0.00033 20.2 0.0 0.87 9.0 0.0 2.6 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.12 012727.3_45724001_1 - 0.0063 15.8 0.0 0.016 14.5 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1676 PF07898.11 012727.3_45724001_1 - 0.027 14.3 0.3 0.055 13.4 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1676) APH PF01636.21 012727.3_45724001_1 - 0.091 12.5 0.0 0.25 11.1 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family GREB1 PF15782.3 012727.3_45724001_1 - 0.39 7.6 3.5 0.48 7.3 3.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CDC45 PF02724.12 012727.3_45724001_1 - 1.7 6.7 9.8 2.4 6.2 9.8 1.4 1 0 0 1 1 1 0 CDC45-like protein Ureide_permease PF07168.9 012727.3_45724001_1 - 4.4 5.8 6.6 3.2 6.3 5.2 1.4 1 1 0 1 1 1 0 Ureide permease BPL_LplA_LipB PF03099.17 001242784.2_26229001_3 - 4.4e-29 100.9 0.0 7.9e-29 100.1 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.15 001242784.2_26229001_3 - 2.8e-10 39.8 0.2 5e-10 39.0 0.2 1.4 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain BPL_N PF09825.7 001242784.2_26229001_3 - 1.9e-09 36.9 0.0 7.8e-06 25.1 0.0 2.1 2 0 0 2 2 2 2 Biotin-protein ligase, N terminal GST_N PF02798.18 001288617.1_32924001_1 - 0.025 14.8 0.0 0.041 14.1 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 001288617.1_32924001_3 - 1.5e-20 73.1 0.0 2.5e-20 72.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 001288617.1_32924001_3 - 1.4e-19 70.0 0.0 2.5e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.18 001288617.1_32924001_3 - 2.3e-08 34.1 0.0 1.9e-07 31.2 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Pkinase PF00069.23 117093.1_32929120_1 - 1.5e-10 40.7 0.0 2.1e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 117093.1_32929120_1 - 2.3e-05 23.7 0.0 3.3e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase CNH PF00780.20 117093.1_32929120_2 - 1.1e-42 146.5 0.0 1.4e-42 146.1 0.0 1.1 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.23 117093.1_32929120_3 - 8.1e-42 143.3 0.0 1.2e-41 142.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 117093.1_32929120_3 - 9.9e-26 90.4 0.0 1.5e-25 89.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase CNH PF00780.20 117093.1_32929120_3 - 1.9e-14 53.8 0.0 2.8e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 CNH domain Kinase-like PF14531.4 117093.1_32929120_3 - 0.16 11.1 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Hormone_recep PF00104.28 135146.1_26225120_2 - 4.7e-26 91.5 1.2 7.8e-26 90.8 1.2 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 135146.1_26225120_3 - 1.8e-28 98.6 14.3 1.8e-28 98.6 14.3 2.1 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) PNMA PF14893.4 001108473.1_45724001_1 - 9e-106 353.9 1.1 1.9e-105 352.8 0.9 1.5 2 0 0 2 2 2 1 PNMA Methyltransf_31 PF13847.4 001243949.1_39723001_1 - 2.6e-09 36.9 0.0 5.1e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 001243949.1_39723001_1 - 4.5e-09 36.8 0.0 7.3e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001243949.1_39723001_1 - 2.5e-08 34.3 0.0 4e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.4 001243949.1_39723001_1 - 5.5e-05 23.0 0.0 8.4e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.4 001243949.1_39723001_1 - 0.001 19.0 0.0 0.0015 18.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001243949.1_39723001_1 - 0.0021 18.6 0.0 0.0054 17.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.12 001243949.1_39723001_1 - 0.018 14.4 0.0 0.04 13.3 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase small domain TPMT PF05724.9 001243949.1_39723001_1 - 0.019 14.5 0.0 0.027 14.0 0.0 1.2 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) COMM_domain PF07258.12 001356614.1_32929001_1 - 7.1e-16 58.0 2.4 1.4e-15 57.1 2.4 1.5 1 0 0 1 1 1 1 COMM domain PAC3 PF10178.7 001356963.1_32922001_3 - 1.3e-27 95.6 0.1 2e-27 95.0 0.1 1.3 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 PLU-1 PF08429.9 001008975.1_39729001_2 - 3.8e-86 289.1 12.2 7.9e-85 284.8 3.3 2.8 3 0 0 3 3 3 2 PLU-1-like protein JmjC PF02373.20 001008975.1_39729001_2 - 4.5e-43 146.2 0.7 9.5e-43 145.1 0.7 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase ARID PF01388.19 001008975.1_39729001_2 - 7.1e-18 64.9 0.0 1.7e-17 63.7 0.0 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.15 001008975.1_39729001_2 - 2.9e-16 59.0 0.4 7e-16 57.8 0.4 1.7 1 0 0 1 1 1 1 jmjN domain PHD PF00628.27 001008975.1_39729001_2 - 1e-15 57.2 13.1 3.4e-12 45.9 2.7 3.4 4 0 0 4 4 4 2 PHD-finger zf-C5HC2 PF02928.14 001008975.1_39729001_2 - 1.7e-15 57.0 11.5 1.7e-15 57.0 11.5 2.6 2 0 0 2 2 2 1 C5HC2 zinc finger Zf_RING PF16744.3 001008975.1_39729001_2 - 0.033 14.2 4.1 4.9 7.2 0.7 2.9 2 0 0 2 2 2 0 KIAA1045 RING finger PHD_4 PF16866.3 001008975.1_39729001_2 - 5.7 7.0 12.1 9.6 6.3 0.8 3.3 2 1 0 2 2 2 0 PHD-finger FAM27 PF15832.3 001035246.1_32928001_1 - 0.12 12.8 23.5 0.019 15.4 7.8 2.5 2 0 0 2 2 2 0 FAM27 D and E protein family FAM27 PF15832.3 001035246.1_32928001_2 - 9.2e-05 22.8 3.9 9.2e-05 22.8 3.9 2.5 2 0 0 2 2 2 1 FAM27 D and E protein family BES1_N PF05687.11 001035246.1_32928001_2 - 3.5 7.9 5.9 6.8 6.9 5.9 1.5 1 0 0 1 1 1 0 BES1/BZR1 plant transcription factor, N-terminal FAM27 PF15832.3 001035246.1_32928001_3 - 0.0015 18.9 4.7 0.0015 18.9 4.7 2.4 2 0 0 2 2 2 1 FAM27 D and E protein family Ank_2 PF12796.5 001286040.1_32929001_1 - 3.9e-42 142.6 2.7 9.2e-13 48.5 0.2 4.1 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001286040.1_32929001_1 - 4.1e-38 128.7 17.1 6.5e-08 32.6 0.4 7.8 4 2 4 8 8 8 6 Ankyrin repeats (many copies) Ank PF00023.28 001286040.1_32929001_1 - 9.4e-34 114.3 12.8 0.00019 21.6 0.1 6.9 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.4 001286040.1_32929001_1 - 1.6e-33 114.5 7.0 1.9e-07 31.4 0.2 6.2 6 1 0 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 001286040.1_32929001_1 - 3.3e-32 106.8 3.6 0.00011 22.2 0.0 7.5 7 0 0 7 7 7 6 Ankyrin repeat SAM_1 PF00536.28 001286040.1_32929001_1 - 1.7e-30 105.1 0.1 2.4e-14 53.4 0.0 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 001286040.1_32929001_1 - 5.2e-25 87.2 0.1 1.2e-13 50.8 0.1 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) PID PF00640.21 001286040.1_32929001_1 - 6e-18 65.1 0.4 1.2e-17 64.1 0.4 1.5 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 001286040.1_32929001_1 - 0.01 15.8 0.0 0.019 15.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotyrosine-binding domain PID_2 PF14719.4 001286040.1_32929001_1 - 0.014 15.2 0.1 0.022 14.5 0.1 1.3 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) WD40 PF00400.30 001280520.1_39724001_1 - 3.9e-67 220.4 24.7 2.9e-09 37.3 0.1 9.2 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001280520.1_39724001_1 - 5.4e-24 84.2 3.2 6.7e-06 26.2 0.1 6.4 2 2 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.10 001280520.1_39724001_1 - 1.9e-11 44.2 0.0 3.9e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 NLE (NUC135) domain Ge1_WD40 PF16529.3 001280520.1_39724001_1 - 2.3e-07 30.0 0.1 0.12 11.2 0.0 4.9 4 2 2 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.9 001280520.1_39724001_1 - 3.1e-07 30.3 0.0 0.26 11.0 0.0 3.7 2 2 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.10 001280520.1_39724001_1 - 4.3e-06 26.4 0.3 0.22 11.4 0.1 5.0 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Nup160 PF11715.6 001280520.1_39724001_1 - 0.00012 20.7 2.9 6.5 5.1 0.0 4.8 3 2 2 5 5 5 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.9 001280520.1_39724001_1 - 0.00074 18.3 0.5 0.96 8.0 0.0 3.4 3 1 0 3 3 3 1 Nup133 N terminal like WD40_like PF17005.3 001280520.1_39724001_1 - 0.0012 18.1 0.0 0.99 8.5 0.0 3.7 4 0 0 4 4 4 1 WD40-like domain Frtz PF11768.6 001280520.1_39724001_1 - 0.0014 16.9 0.0 0.46 8.6 0.0 2.9 2 2 1 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz Nbas_N PF15492.4 001280520.1_39724001_1 - 0.015 14.5 2.5 13 4.9 0.1 4.3 3 2 3 6 6 6 0 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.14 001280520.1_39724001_1 - 0.03 12.7 0.0 0.86 7.9 0.0 2.6 3 0 0 3 3 3 0 Cytochrome D1 heme domain PALB2_WD40 PF16756.3 001280520.1_39724001_1 - 0.098 11.4 7.1 4.7 5.9 0.1 3.5 3 1 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain EGF_CA PF07645.13 001244261.1_49827001_1 - 5.1e-46 154.5 88.8 4.7e-13 49.0 6.0 8.3 8 0 0 8 8 8 6 Calcium-binding EGF domain cEGF PF12662.5 001244261.1_49827001_1 - 1.6e-36 123.7 38.0 5.2e-09 35.7 0.6 7.1 6 0 0 6 6 6 6 Complement Clr-like EGF-like FXa_inhibition PF14670.4 001244261.1_49827001_1 - 4.7e-07 29.8 36.7 8.6e-06 25.8 7.0 7.6 8 1 1 9 9 9 4 Coagulation Factor Xa inhibitory site EGF_3 PF12947.5 001244261.1_49827001_1 - 0.00013 22.0 7.5 0.00013 22.0 7.5 7.1 6 2 1 7 7 7 4 EGF domain EGF PF00008.25 001244261.1_49827001_1 - 0.00037 20.6 82.8 0.0039 17.3 5.5 7.5 8 0 0 8 8 8 5 EGF-like domain hEGF PF12661.5 001244261.1_49827001_1 - 0.0004 20.8 2.1 0.0004 20.8 2.1 8.2 8 1 0 8 8 8 4 Human growth factor-like EGF TNFR_c6 PF00020.16 012610.2_45727001_3 - 1.4e-19 70.1 63.2 3.3e-10 40.1 8.3 5.5 5 0 0 5 5 5 4 TNFR/NGFR cysteine-rich region Death PF00531.20 012610.2_45727001_3 - 5.2e-12 45.6 0.1 8.5e-12 44.9 0.1 1.3 1 0 0 1 1 1 1 Death domain 7tm_1 PF00001.19 001309049.1_22424001_1 - 3.5e-50 170.6 30.2 5.8e-50 169.9 30.2 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001309049.1_22424001_1 - 0.00017 20.9 19.8 0.00017 20.9 19.8 2.3 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx MscS_TM PF12794.5 001309049.1_22424001_1 - 0.25 10.0 5.1 0.41 9.3 0.3 2.2 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 TIMP PF00965.15 151459.1_32926120_1 - 1.9e-46 158.1 5.4 2.8e-46 157.5 5.4 1.2 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase TIMP PF00965.15 151459.1_32926120_2 - 1.1e-10 41.4 1.0 2.2e-10 40.5 1.0 1.4 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase Rhabdo_NV PF02484.13 151459.1_32926120_3 - 0.13 12.3 0.1 0.47 10.5 0.0 1.8 2 0 0 2 2 2 0 Rhabdovirus Non-virion protein His_Phos_2 PF00328.20 001357041.1_29625001_3 - 5.3e-34 118.1 0.2 1.1e-30 107.1 0.0 2.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) RbsD_FucU PF05025.11 001301827.1_26222001_1 - 5.3e-28 98.0 0.0 2.6e-21 76.3 0.0 2.1 1 1 1 2 2 2 2 RbsD / FucU transport protein family Guanylate_cyc PF00211.18 021684.1_45729001_1 - 3.5e-25 88.5 2.9 1.2e-12 47.8 0.1 2.4 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain AAA_16 PF13191.4 021684.1_45729001_1 - 7.3e-06 26.3 0.0 1.6e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 021684.1_45729001_1 - 0.00012 22.2 0.0 0.0004 20.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain TPR_8 PF13181.4 021684.1_45729001_1 - 0.00043 20.1 6.7 0.16 12.1 0.1 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat AAA_19 PF13245.4 021684.1_45729001_1 - 0.0077 16.4 0.2 0.022 15.0 0.2 1.7 1 1 0 1 1 1 1 AAA domain DUF577 PF04510.10 021684.1_45729001_1 - 0.01 15.6 0.2 0.053 13.3 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF577) TPR_1 PF00515.26 021684.1_45729001_1 - 0.16 11.7 0.1 0.16 11.7 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.4 021684.1_45729001_1 - 0.7 10.1 7.9 25 5.1 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat Kazal_2 PF07648.13 001081811.2_21025001_1 - 4.6e-35 119.4 27.9 5.6e-13 48.7 1.6 4.2 4 0 0 4 4 4 3 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 001081811.2_21025001_1 - 1.1e-16 60.5 41.8 7.9e-07 28.9 5.0 4.0 4 0 0 4 4 4 3 Kazal-type serine protease inhibitor domain FOLN PF09289.8 001081811.2_21025001_1 - 2.3e-06 27.6 13.0 2.3e-06 27.6 13.0 4.1 3 0 0 3 3 3 1 Follistatin/Osteonectin-like EGF domain STIMATE PF12400.6 001251863.2_39729001_3 - 7.3e-32 110.4 8.6 1.4e-31 109.5 8.6 1.5 1 0 0 1 1 1 1 STIMATE family DUF4683 PF15735.3 001206172.1_06529001_1 - 4.6e-166 553.3 17.0 4.6e-166 553.3 17.0 4.2 4 0 0 4 4 4 1 Domain of unknown function (DUF4683) DNA_pol_B PF00136.19 001206172.1_06529001_1 - 1.1e-101 340.7 0.0 1.7e-101 340.1 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.17 001206172.1_06529001_1 - 2.4e-28 99.1 0.0 1.1e-15 57.5 0.1 2.6 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.4 001206172.1_06529001_1 - 4.9e-12 46.0 9.5 4.9e-12 46.0 9.5 2.8 2 0 0 2 2 2 1 C4-type zinc-finger of DNA polymerase delta Oxysterol_BP PF01237.16 001205970.1_06528001_3 - 9.5e-145 481.9 0.0 1.7e-144 481.1 0.0 1.4 1 0 0 1 1 1 1 Oxysterol-binding protein PH PF00169.27 001205970.1_06528001_3 - 4.2e-15 56.0 0.1 9e-15 54.9 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 001205970.1_06528001_3 - 6e-11 42.4 0.2 1.2e-10 41.4 0.2 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.4 001205970.1_06528001_3 - 3.4e-05 24.0 0.0 0.00011 22.3 0.0 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.4 001205970.1_06528001_3 - 0.00011 22.4 3.7 0.0075 16.5 3.7 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain Syntaxin-6_N PF09177.9 001205970.1_06528001_3 - 0.4 11.1 5.6 0.39 11.2 2.2 2.5 2 0 0 2 2 2 0 Syntaxin 6, N-terminal VCBS PF13517.4 001205325.1_06525001_2 - 2.4e-29 101.6 8.7 3.5e-09 37.0 1.9 5.0 3 2 1 4 4 4 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella UnbV_ASPIC PF07593.10 001205325.1_06525001_2 - 5e-15 55.1 0.0 1e-14 54.1 0.0 1.5 1 0 0 1 1 1 1 ASPIC and UnbV FG-GAP PF01839.21 001205325.1_06525001_2 - 4.2e-12 45.8 16.6 0.0041 17.1 0.9 5.1 5 0 0 5 5 5 3 FG-GAP repeat EGF_CA PF07645.13 001205325.1_06525001_2 - 1.3e-11 44.3 7.0 1.3e-11 44.3 7.0 2.2 2 0 0 2 2 2 1 Calcium-binding EGF domain LacI PF00356.19 001205325.1_06525001_2 - 0.18 11.5 0.1 0.36 10.5 0.1 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family cEGF PF12662.5 001205325.1_06525001_2 - 1.5 8.7 15.9 0.059 13.2 2.0 3.1 3 0 0 3 3 3 0 Complement Clr-like EGF-like CEP170_C PF15308.4 001035377.2_06529001_3 - 1.7e-262 872.8 62.6 1.7e-262 872.8 62.6 3.3 3 0 0 3 3 3 1 CEP170 C-terminus FHA PF00498.24 001035377.2_06529001_3 - 3.4e-15 56.0 0.1 9.3e-15 54.6 0.1 1.8 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.3 001035377.2_06529001_3 - 1.9e-08 34.4 0.1 6.1e-08 32.7 0.0 1.9 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain DUF4254 PF14063.4 001035377.2_06529001_3 - 0.012 15.3 1.4 0.054 13.2 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4254) CUB PF00431.18 001192694.1_06525001_1 - 4.5e-39 133.1 0.4 1.7e-25 89.4 0.0 2.7 3 0 0 3 3 3 2 CUB domain Ldl_recept_a PF00057.16 001192694.1_06525001_1 - 4.9e-07 29.7 2.6 4.9e-07 29.7 2.6 2.5 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A Folate_rec PF03024.12 213830.1_49823001_1 - 2e-64 216.4 24.0 2.6e-64 216.1 24.0 1.1 1 0 0 1 1 1 1 Folate receptor family PP2C PF00481.19 048561.1_26229120_2 - 1.7e-58 198.1 0.1 2.6e-58 197.6 0.1 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.4 048561.1_26229120_2 - 0.007 15.9 0.1 0.013 15.0 0.1 1.5 1 0 0 1 1 1 1 Protein phosphatase 2C TPT PF03151.14 045544.1_32924120_3 - 2.8e-24 85.8 14.1 3.6e-24 85.5 14.1 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.18 045544.1_32924120_3 - 1e-06 28.8 39.7 7e-06 26.1 12.2 2.3 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.9 045544.1_32924120_3 - 1.9e-05 23.9 20.4 2.5e-05 23.5 20.4 1.1 1 0 0 1 1 1 1 UAA transporter family SPC25 PF06703.9 045544.1_32924120_3 - 5.8 6.6 6.7 8.7 6.0 0.7 2.3 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) GTSE1_N PF15259.4 001046501.1_06524001_3 - 3.2e-10 40.2 0.0 1.3e-09 38.2 0.0 2.0 1 1 1 2 2 2 1 G-2 and S-phase expressed 1 Ank_2 PF12796.5 174209.2_06529001_1 - 1.2e-27 96.1 2.8 3.2e-11 43.5 0.1 4.2 2 1 2 4 4 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 174209.2_06529001_1 - 1.7e-25 88.6 6.7 3.3e-06 27.2 0.1 4.7 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.4 174209.2_06529001_1 - 1.8e-23 82.4 2.1 2.1e-07 31.2 0.1 5.2 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 174209.2_06529001_1 - 5e-23 78.6 1.8 0.0011 19.1 0.0 6.8 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.28 174209.2_06529001_1 - 9.9e-22 76.3 8.4 3.6e-05 23.9 0.1 6.0 5 0 0 5 5 5 5 Ankyrin repeat Atg14 PF10186.7 174209.2_06529001_1 - 0.00052 19.1 6.7 0.00052 19.1 6.7 9.2 1 1 5 8 8 6 1 Vacuolar sorting 38 and autophagy-related subunit 14 Lebercilin PF15619.4 174209.2_06529001_1 - 0.002 17.7 37.0 0.002 17.7 37.0 10.6 3 2 8 11 11 9 2 Ciliary protein causing Leber congenital amaurosis disease BRE1 PF08647.9 174209.2_06529001_1 - 0.0025 17.7 11.1 0.0025 17.7 11.1 13.0 5 4 6 12 12 11 1 BRE1 E3 ubiquitin ligase ATG16 PF08614.9 174209.2_06529001_1 - 0.0041 17.2 4.8 0.0041 17.2 4.8 11.6 4 4 7 11 11 10 3 Autophagy protein 16 (ATG16) IncA PF04156.12 174209.2_06529001_1 - 0.0052 16.5 5.6 0.0052 16.5 5.6 11.0 3 2 7 10 10 10 3 IncA protein DUF3467 PF11950.6 174209.2_06529001_1 - 0.1 12.6 2.0 0.35 11.0 0.2 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3467) Gal-3-0_sulfotr PF06990.9 001075840.1_06525001_2 - 2.5e-198 658.8 2.4 3e-198 658.5 2.4 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.12 001075840.1_06525001_2 - 0.0013 18.5 0.0 0.002 17.9 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family Syndecan PF01034.18 001075924.1_06525001_1 - 6.8e-26 89.8 0.0 1e-25 89.3 0.0 1.3 1 0 0 1 1 1 1 Syndecan domain LRR_6 PF13516.4 001046386.1_06524001_3 - 3.3e-09 35.9 7.1 0.077 13.0 0.1 4.5 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.5 001046386.1_06524001_3 - 0.0027 17.9 3.2 0.55 10.6 0.1 3.5 1 1 3 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001046386.1_06524001_3 - 0.0097 15.5 1.6 0.19 11.4 0.1 2.7 2 1 0 2 2 2 1 Leucine rich repeat SCAN PF02023.15 001076174.1_06524001_3 - 2.2e-38 129.8 1.5 3.9e-38 129.0 1.5 1.4 1 0 0 1 1 1 1 SCAN domain MAP7 PF05672.9 001101874.1_06529001_3 - 4e-41 140.3 83.6 4e-41 140.3 83.6 2.8 2 1 0 2 2 2 1 MAP7 (E-MAP-115) family PH_5 PF15405.4 001101874.1_06529001_3 - 0.0038 17.2 0.2 0.014 15.4 0.2 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain Pro_isomerase PF00160.19 001109807.1_06526001_1 - 6.5e-49 166.1 0.3 4.4e-48 163.4 0.3 2.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SR-25 PF10500.7 001109807.1_06526001_1 - 1.9e-07 30.8 40.8 1.9e-07 30.8 40.8 5.9 3 1 3 6 6 6 1 Nuclear RNA-splicing-associated protein Apt1 PF10351.7 001109807.1_06526001_1 - 0.25 10.0 0.0 0.25 10.0 0.0 5.2 1 1 4 5 5 5 0 Golgi-body localisation protein domain DUF4604 PF15377.4 001109807.1_06526001_2 - 0.0086 16.4 2.6 0.0086 16.4 2.6 3.5 4 0 0 4 4 4 1 Domain of unknown function (DUF4604) Acetyltransf_1 PF00583.23 203323.3_06523001_2 - 4e-19 68.8 0.1 5.8e-19 68.3 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.5 203323.3_06523001_2 - 5.8e-10 39.3 0.1 9.6e-10 38.6 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.5 203323.3_06523001_2 - 2.7e-06 27.2 0.0 4.4e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.8 203323.3_06523001_2 - 1.7e-05 24.6 0.0 3.1e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.4 203323.3_06523001_2 - 5.4e-05 23.1 0.0 0.00011 22.2 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.5 203323.3_06523001_2 - 0.023 15.2 0.0 0.031 14.8 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain EOS1 PF12326.6 203323.3_06523001_2 - 0.16 11.8 2.9 0.18 11.6 2.9 1.2 1 0 0 1 1 1 0 N-glycosylation protein 7tm_1 PF00001.19 203323.3_06523001_3 - 0.048 12.8 0.4 0.031 13.4 0.4 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) EOS1 PF12326.6 203323.3_06523001_3 - 0.13 12.1 2.2 0.17 11.7 2.2 1.3 1 0 0 1 1 1 0 N-glycosylation protein FKBP_C PF00254.26 001077969.2_06522001_1 - 7.4e-35 119.0 0.0 1.8e-34 117.8 0.0 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase RNA_pol_Rpc4 PF05132.12 001077969.2_06522001_1 - 0.00014 22.2 12.2 0.00025 21.4 12.2 1.5 1 0 0 1 1 1 1 RNA polymerase III RPC4 EOS1 PF12326.6 001077969.2_06522001_1 - 0.3 10.9 8.1 0.39 10.5 8.1 1.3 1 0 0 1 1 1 0 N-glycosylation protein Neur_chan_memb PF02932.14 001077969.2_06522001_1 - 0.31 10.9 5.9 0.35 10.8 5.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF913 PF06025.10 001077969.2_06522001_1 - 0.83 8.4 7.1 0.95 8.2 7.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DDHD PF02862.15 001077969.2_06522001_1 - 3.4 7.6 13.8 4.3 7.3 13.8 1.1 1 0 0 1 1 1 0 DDHD domain RNA_pol_Rpc4 PF05132.12 001077969.2_06522001_2 - 1.3e-05 25.5 6.7 1.7e-05 25.2 6.7 1.2 1 0 0 1 1 1 1 RNA polymerase III RPC4 DDHD PF02862.15 001077969.2_06522001_2 - 0.053 13.5 7.2 0.062 13.3 7.2 1.1 1 0 0 1 1 1 0 DDHD domain DUF913 PF06025.10 001077969.2_06522001_2 - 0.19 10.5 5.2 0.23 10.2 5.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) EOS1 PF12326.6 001077969.2_06522001_2 - 0.29 10.9 7.0 0.37 10.6 7.0 1.3 1 0 0 1 1 1 0 N-glycosylation protein Zip PF02535.20 001077969.2_06522001_2 - 3.6 6.6 10.5 4.3 6.3 10.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter RNA_pol_Rpc4 PF05132.12 001077969.2_06522001_3 - 0.0015 18.8 14.6 0.0019 18.5 14.6 1.2 1 0 0 1 1 1 1 RNA polymerase III RPC4 DDHD PF02862.15 001077969.2_06522001_3 - 0.014 15.4 8.0 0.016 15.2 8.0 1.1 1 0 0 1 1 1 0 DDHD domain Afi1 PF07792.10 001077969.2_06522001_3 - 0.098 13.0 10.3 0.14 12.5 10.3 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Neur_chan_memb PF02932.14 001077969.2_06522001_3 - 1.6 8.6 9.4 1.9 8.4 9.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region S_100 PF01023.17 001081890.1_21021001_1 - 1.6e-13 50.0 1.0 7.2e-13 47.9 0.3 2.1 2 0 0 2 2 2 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.30 001081890.1_21021001_1 - 1.8e-10 39.5 3.7 4.2e-09 35.2 0.8 3.0 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.4 001081890.1_21021001_1 - 1.2e-09 38.4 0.8 7.9e-09 35.7 0.7 2.0 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.4 001081890.1_21021001_1 - 4.9e-09 35.2 7.6 2.5e-08 32.9 1.4 3.0 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.4 001081890.1_21021001_1 - 1.8e-08 33.5 1.9 1.9e-06 27.2 0.3 2.6 2 1 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.4 001081890.1_21021001_1 - 1.7e-07 30.7 0.7 5.2e-07 29.2 0.7 1.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_4 PF12763.5 001081890.1_21021001_1 - 0.02 14.7 0.2 0.022 14.6 0.2 1.1 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 001081890.1_21021001_1 - 0.061 13.5 0.0 0.075 13.2 0.0 1.2 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.11 001081890.1_21021001_1 - 0.065 13.0 0.1 2 8.1 0.0 2.0 2 0 0 2 2 2 0 Caleosin related protein PAX PF00292.16 001040645.1_06524001_2 - 8.6e-72 238.8 0.8 1.5e-71 238.1 0.8 1.4 1 0 0 1 1 1 1 'Paired box' domain Homeobox PF00046.27 001040645.1_06524001_2 - 6.9e-23 80.1 4.5 1.4e-22 79.1 4.5 1.6 1 0 0 1 1 1 1 Homeobox domain HTH_32 PF13565.4 001040645.1_06524001_2 - 2.6e-05 24.6 1.2 0.0046 17.4 0.0 3.3 3 1 0 3 3 3 1 Homeodomain-like domain HTH_23 PF13384.4 001040645.1_06524001_2 - 0.003 17.2 0.0 0.012 15.3 0.0 1.9 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_IS1 PF12759.5 001040645.1_06524001_2 - 0.0054 16.2 0.0 0.019 14.4 0.0 1.8 2 0 0 2 2 2 1 InsA C-terminal domain HTH_28 PF13518.4 001040645.1_06524001_2 - 0.3 11.1 0.0 0.3 11.1 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain ILEI PF15711.3 001076309.1_06523001_1 - 2.7e-25 88.5 0.0 4.3e-25 87.9 0.0 1.3 1 0 0 1 1 1 1 Interleukin-like EMT inducer OATP PF03137.18 001081789.2_21027001_2 - 1.1e-194 647.7 7.0 1.4e-194 647.3 7.0 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 001081789.2_21027001_2 - 6e-19 68.0 21.2 6e-19 68.0 21.2 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily Kazal_2 PF07648.13 001081789.2_21027001_2 - 0.56 10.3 7.2 1.5 9.0 7.2 1.8 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain TP1 PF02079.14 174199.2_06521001_3 - 5.5e-28 96.4 18.3 8.3e-28 95.9 18.3 1.3 1 0 0 1 1 1 1 Nuclear transition protein 1 Calsarcin PF05556.9 001078039.1_06527001_1 - 9.5e-34 116.8 0.0 1.7e-33 116.0 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-binding protein (Calsarcin) Sec1 PF00995.21 001046208.2_06524001_1 - 6.4e-127 425.0 0.0 7.2e-127 424.8 0.0 1.0 1 0 0 1 1 1 1 Sec1 family DASH_Hsk3 PF08227.9 001046208.2_06524001_1 - 0.078 13.2 3.6 0.22 11.8 0.5 3.2 4 0 0 4 4 4 0 DASH complex subunit Hsk3 like YlbD_coat PF14071.4 001046208.2_06524001_1 - 0.12 12.5 0.5 0.31 11.2 0.2 1.8 2 0 0 2 2 2 0 Putative coat protein TFIIA_gamma_C PF02751.12 001037619.2_06522001_2 - 1.4e-23 82.5 2.5 2.4e-23 81.8 2.5 1.4 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.14 001037619.2_06522001_2 - 4.7e-23 80.8 0.4 6.9e-23 80.3 0.4 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain UPAR_LY6 PF00021.19 001105024.1_06523001_1 - 6.1e-17 62.0 15.8 2.4e-15 56.9 10.0 2.5 2 0 0 2 2 2 2 u-PAR/Ly-6 domain FTHFS PF01268.17 001076018.2_06528001_2 - 2.2e-259 861.2 0.1 2.6e-259 860.9 0.1 1.1 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.17 001076018.2_06528001_2 - 1.7e-25 89.0 0.0 7.9e-25 86.9 0.0 2.0 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.21 001076018.2_06528001_2 - 2.1e-16 60.1 2.8 2.9e-16 59.7 0.7 2.1 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Ldh_1_C PF02866.16 001076018.2_06528001_2 - 0.14 11.9 0.0 0.47 10.2 0.0 1.8 2 0 0 2 2 2 0 lactate/malate dehydrogenase, alpha/beta C-terminal domain Prion PF00377.16 001091537.1_21022001_1 - 1.1e-48 163.8 0.1 1.4e-48 163.4 0.1 1.2 1 0 0 1 1 1 1 Prion/Doppel alpha-helical domain Doppel PF11466.6 001091537.1_21022001_1 - 5.7e-19 67.3 1.3 5.7e-19 67.3 1.3 2.0 2 0 0 2 2 2 1 Prion-like protein Doppel MIF4G PF02854.17 001091537.1_21022001_1 - 0.052 13.1 0.2 0.073 12.6 0.2 1.1 1 0 0 1 1 1 0 MIF4G domain RSN1_7TM PF02714.13 001110440.2_06526001_1 - 0.023 13.9 0.1 0.04 13.1 0.1 1.3 1 0 0 1 1 1 0 Calcium-dependent channel, 7TM region, putative phosphate TMC PF07810.11 001110440.2_06526001_2 - 6.2e-42 142.5 1.0 1.5e-41 141.3 1.0 1.7 1 0 0 1 1 1 1 TMC domain Cyclin_N PF00134.21 001076372.1_06522001_2 - 3.5e-37 126.9 0.4 5.6e-37 126.2 0.4 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 001076372.1_06522001_2 - 6.8e-19 68.0 0.0 2.7e-18 66.1 0.0 1.9 2 0 0 2 2 2 1 Cyclin, C-terminal domain K-cyclin_vir_C PF09080.8 001076372.1_06522001_2 - 0.00067 19.9 0.1 0.0011 19.3 0.1 1.3 1 0 0 1 1 1 1 K cyclin, C terminal Hormone_1 PF00103.18 001038200.1_06522001_2 - 2.2e-77 259.5 6.0 2.6e-77 259.3 6.0 1.0 1 0 0 1 1 1 1 Somatotropin hormone family Nuc_sug_transp PF04142.13 176640.2_06523001_2 - 1.7e-134 447.8 9.0 2e-134 447.6 9.0 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.18 176640.2_06523001_2 - 1.6e-05 25.0 30.2 0.00024 21.2 7.8 2.6 2 1 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.3 176640.2_06523001_2 - 0.016 14.3 8.1 0.025 13.7 8.1 1.5 1 1 0 1 1 1 0 Purine nucleobase transmembrane transport TPT PF03151.14 176640.2_06523001_2 - 0.068 12.4 9.3 0.34 10.1 1.7 2.4 3 0 0 3 3 3 0 Triose-phosphate Transporter family UAA PF08449.9 176640.2_06523001_2 - 1.5 7.8 15.1 0.57 9.2 9.8 2.6 1 1 1 2 2 2 0 UAA transporter family TraL PF07178.9 176640.2_06523001_2 - 5.6 7.4 5.7 15 5.9 0.3 3.2 3 0 0 3 3 3 0 TraL protein p450 PF00067.20 001111337.1_21023001_1 - 4.9e-148 493.6 0.3 5.5e-148 493.4 0.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 Carb_anhydrase PF00194.19 001099760.1_21023001_1 - 7.3e-91 304.1 0.1 8.5e-91 303.9 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Aminotran_3 PF00202.19 001075821.2_06524001_3 - 5.3e-92 308.4 0.0 8.6e-92 307.8 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class-III 6PF2K PF01591.16 174572.4_06524001_3 - 2.6e-103 344.0 0.2 7.3e-103 342.5 0.1 1.7 2 0 0 2 2 2 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.20 174572.4_06524001_3 - 5.5e-42 143.5 0.0 7.4e-42 143.1 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.4 174572.4_06524001_3 - 1.6e-08 34.7 0.0 4.4e-08 33.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.10 174572.4_06524001_3 - 0.0016 17.6 0.0 0.005 16.0 0.0 1.9 1 1 0 1 1 1 1 Zeta toxin KTI12 PF08433.8 174572.4_06524001_3 - 0.016 14.5 0.0 0.03 13.6 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 GST_C_2 PF13410.4 174276.3_06524001_2 - 1.1e-06 28.3 0.0 2.6e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 174276.3_06524001_2 - 3.3e-06 27.2 0.0 6.6e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 174276.3_06524001_2 - 4.2e-05 23.7 0.0 8.3e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 174276.3_06524001_2 - 0.0022 18.0 0.7 0.0071 16.4 0.1 2.2 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain DUF2457 PF10446.7 174276.3_06524001_3 - 8 5.4 11.4 21 4.0 11.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) F-box-like PF12937.5 001035021.1_06524001_3 - 3.4e-12 45.9 0.4 9e-12 44.6 0.4 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001035021.1_06524001_3 - 4.8e-07 29.4 0.2 1.1e-06 28.2 0.2 1.7 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.3 001035021.1_06524001_3 - 0.0018 18.0 0.0 0.0041 16.9 0.0 1.7 1 0 0 1 1 1 1 F-box DUF423 PF04241.13 001045957.1_06522001_2 - 5.1e-17 61.7 0.4 9.5e-17 60.9 0.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF423) TPR_12 PF13424.4 001103308.2_06525001_1 - 2.9e-15 56.2 6.4 2.4e-05 24.4 0.7 5.3 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.26 001103308.2_06525001_1 - 4.7e-12 45.1 7.8 0.21 11.3 0.0 7.4 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_2 PF07719.15 001103308.2_06525001_1 - 7.2e-12 44.3 11.4 0.5 10.5 0.1 8.0 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_8 PF13181.4 001103308.2_06525001_1 - 8.3e-07 28.6 6.9 0.17 12.0 0.0 7.5 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_7 PF13176.4 001103308.2_06525001_1 - 2e-06 27.3 7.4 0.13 12.2 0.0 6.3 9 0 0 9 9 9 2 Tetratricopeptide repeat RPN7 PF10602.7 001103308.2_06525001_1 - 6.7e-06 25.7 2.1 0.001 18.6 0.1 3.3 2 2 1 3 3 3 1 26S proteasome subunit RPN7 TPR_19 PF14559.4 001103308.2_06525001_1 - 5.5e-05 23.5 4.0 1.9 8.9 0.0 4.5 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.4 001103308.2_06525001_1 - 9.2e-05 22.9 0.4 6 7.5 0.2 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.5 001103308.2_06525001_1 - 0.0022 18.1 4.9 0.25 11.4 0.7 4.0 2 2 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF3856 PF12968.5 001103308.2_06525001_1 - 0.057 13.4 1.2 24 4.8 0.1 4.1 3 2 0 3 3 3 0 Domain of Unknown Function (DUF3856) TPR_17 PF13431.4 001103308.2_06525001_1 - 0.062 13.6 0.1 64 4.1 0.0 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.4 001103308.2_06525001_1 - 0.3 10.9 4.1 38 4.2 0.1 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.4 001103308.2_06525001_1 - 0.82 10.3 4.9 97 3.8 0.0 5.3 6 0 0 6 6 4 0 Tetratricopeptide repeat Ank_4 PF13637.4 001075471.2_06524001_1 - 1.3e-26 92.4 5.1 1.8e-11 44.1 0.1 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 001075471.2_06524001_1 - 9.5e-25 86.9 0.3 4.2e-12 46.4 0.3 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 001075471.2_06524001_1 - 8.6e-21 73.3 5.3 6.6e-07 29.4 0.1 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.4 001075471.2_06524001_1 - 4.5e-20 69.5 0.7 1.5e-05 24.8 0.0 4.5 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.4 001075471.2_06524001_1 - 1.4e-19 69.7 0.9 2.5e-06 27.5 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) DUF1899 PF08953.9 001038220.1_06529001_2 - 8.2e-30 102.4 0.1 1.4e-29 101.6 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.3 001038220.1_06529001_2 - 3.9e-21 74.5 0.1 7e-21 73.7 0.1 1.4 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.30 001038220.1_06529001_2 - 1.4e-14 54.1 0.9 5e-05 23.9 0.1 4.1 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001038220.1_06529001_2 - 6.8e-05 23.0 0.1 0.0045 17.1 0.0 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain PMP22_Claudin PF00822.18 001105609.2_06523001_3 - 3e-41 140.9 9.7 4.1e-41 140.5 9.7 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001105609.2_06523001_3 - 1.2e-06 28.3 13.7 1.5e-05 24.7 13.7 2.0 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction YccF PF03733.11 001105609.2_06523001_3 - 0.14 12.8 0.2 0.14 12.8 0.2 2.8 3 1 1 4 4 4 0 Inner membrane component domain Clc-like PF07062.10 001105609.2_06523001_3 - 0.41 9.9 6.9 0.25 10.6 0.2 2.1 1 1 1 2 2 2 0 Clc-like DUF4064 PF13273.4 001105609.2_06523001_3 - 0.73 10.1 9.3 4.8 7.5 3.4 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) TAFA PF12020.6 001077000.1_06523001_1 - 9e-44 147.7 9.5 2e-43 146.6 9.5 1.6 1 0 0 1 1 1 1 TAFA family YwqJ-deaminase PF14431.4 001077000.1_06523001_2 - 0.056 13.5 0.1 0.087 12.9 0.1 1.3 1 0 0 1 1 1 0 YwqJ-like deaminase Copper-fist PF00649.16 001103251.1_06525001_1 - 0.00066 19.0 0.4 7.8 5.9 0.0 3.8 3 0 0 3 3 3 3 Copper fist DNA binding domain zf-H2C2_2 PF13465.4 001103251.1_06525001_3 - 5e-90 292.1 95.8 3.3e-09 36.6 0.4 12.9 13 0 0 13 13 12 12 Zinc-finger double domain zf-C2H2 PF00096.24 001103251.1_06525001_3 - 3.7e-46 152.9 85.6 2.9e-05 24.2 1.1 12.8 13 0 0 13 13 13 11 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 001103251.1_06525001_3 - 2.1e-29 100.8 78.4 0.00046 19.9 0.5 12.7 12 0 0 12 12 12 11 C2H2-type zinc finger zf-C2H2_4 PF13894.4 001103251.1_06525001_3 - 7.3e-27 91.6 81.7 0.0017 18.9 0.8 12.5 12 0 0 12 12 12 11 C2H2-type zinc finger KRAB PF01352.25 001103251.1_06525001_3 - 3.8e-25 87.2 1.2 8.2e-25 86.1 1.2 1.6 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 001103251.1_06525001_3 - 2.2e-16 59.6 64.4 0.00084 19.3 1.0 7.8 6 2 1 7 7 7 6 Zinc ribbon domain zf-C2H2_jaz PF12171.6 001103251.1_06525001_3 - 1.1e-10 41.4 55.9 0.054 13.7 1.7 11.7 12 0 0 12 12 12 5 Zinc-finger double-stranded RNA-binding XPA_N PF01286.16 001103251.1_06525001_3 - 3e-06 27.0 56.2 4 7.4 0.0 12.4 12 0 0 12 12 12 4 XPA protein N-terminal zf-trcl PF13451.4 001103251.1_06525001_3 - 0.0005 19.8 60.3 2.3 8.1 0.1 11.1 10 2 0 10 10 10 3 Probable zinc-ribbon domain zinc_ribbon_15 PF17032.3 001103251.1_06525001_3 - 0.0019 18.8 53.0 0.4 11.3 3.1 6.9 2 1 3 6 6 6 3 zinc-ribbon family C1_4 PF07975.10 001103251.1_06525001_3 - 1 9.6 54.9 0.64 10.2 1.5 8.0 2 2 8 10 10 10 0 TFIIH C1-like domain zf-C2H2_11 PF16622.3 001103251.1_06525001_3 - 2 8.1 56.9 3.1 7.5 0.2 11.4 12 0 0 12 12 12 0 zinc-finger C2H2-type DUF3268 PF11672.6 001103251.1_06525001_3 - 8.8 6.6 40.9 2.8 8.2 2.5 6.1 5 2 0 5 5 5 0 zinc-finger-containing domain AA_permease_2 PF13520.4 001083673.1_06527001_1 - 2.7e-41 141.7 19.7 2.7e-41 141.7 19.7 2.2 1 1 1 2 2 2 2 Amino acid permease AA_permease PF00324.19 001083673.1_06527001_1 - 5e-33 114.3 23.2 5e-33 114.3 23.2 2.2 2 0 0 2 2 2 1 Amino acid permease AA_permease_C PF13906.4 001083673.1_06527001_1 - 2.5e-23 81.8 7.5 2.5e-23 81.8 7.5 2.9 2 0 0 2 2 2 1 C-terminus of AA_permease YMF19 PF02326.13 001101067.2_06527001_1 - 1.3 9.7 10.6 2.3 9.0 10.6 1.3 1 0 0 1 1 1 0 Plant ATP synthase F0 ThiF PF00899.19 001101067.2_06527001_2 - 6.5e-48 163.1 0.1 9.4e-48 162.6 0.1 1.1 1 0 0 1 1 1 1 ThiF family DUF788 PF05620.9 001101067.2_06527001_2 - 0.0022 17.8 7.6 0.22 11.3 6.7 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF788) UDPG_MGDP_dh_N PF03721.12 001101067.2_06527001_2 - 0.01 15.3 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pox_A_type_inc PF04508.10 001101067.2_06527001_2 - 0.031 14.0 3.3 0.085 12.6 3.3 1.8 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Sacchrp_dh_NADP PF03435.16 001101067.2_06527001_2 - 0.12 12.5 0.5 2 8.5 0.5 2.4 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain 2-Hacid_dh_C PF02826.17 001101067.2_06527001_2 - 0.15 11.3 0.0 0.28 10.4 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain OAD_gamma PF04277.11 001101067.2_06527001_3 - 0.1 13.1 2.4 0.23 11.9 2.4 1.6 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain MHC_I PF00129.16 001076841.1_06524001_2 - 6.1e-47 159.3 3.5 3e-46 157.1 3.5 1.9 1 1 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001076841.1_06524001_2 - 1.5e-16 60.5 0.0 3.3e-16 59.4 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin C1-set domain C2-set_2 PF08205.10 001076841.1_06524001_2 - 9.3e-05 22.3 0.3 0.00019 21.3 0.3 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001076841.1_06524001_2 - 0.0019 18.2 0.1 0.0053 16.8 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001076841.1_06524001_2 - 0.043 14.0 0.0 0.099 12.9 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain BCIP PF13862.4 001046122.2_06523001_1 - 1.7e-56 191.2 2.6 1.7e-56 191.2 2.6 3.3 2 1 0 2 2 2 1 p21-C-terminal region-binding protein Presenilin PF01080.15 001046122.2_06523001_1 - 3.9 6.0 11.3 0.32 9.6 5.0 2.0 2 0 0 2 2 2 0 Presenilin RNA_pol_Rpc4 PF05132.12 001046122.2_06523001_2 - 8.4 6.7 19.7 14 6.0 19.7 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 EOS1 PF12326.6 001046122.2_06523001_3 - 0.047 13.5 1.4 0.048 13.5 1.4 1.2 1 0 0 1 1 1 0 N-glycosylation protein G-gamma PF00631.20 001103324.1_06529001_2 - 4.8e-14 52.0 0.1 7.9e-14 51.3 0.1 1.4 1 0 0 1 1 1 1 GGL domain Actin PF00022.17 001076361.1_06525001_1 - 1.2e-32 112.9 0.0 1.5e-15 56.6 0.0 3.1 2 1 0 2 2 2 2 Actin Actin_micro PF17003.3 001076361.1_06525001_1 - 1.1e-14 54.3 0.2 1.7e-07 30.6 0.1 2.1 2 0 0 2 2 2 2 Putative actin-like family p450 PF00067.20 001101651.1_21025001_3 - 5.2e-134 447.3 0.9 6.8e-134 446.9 0.9 1.2 1 0 0 1 1 1 1 Cytochrome P450 AP3D1 PF06375.9 001101651.1_21025001_3 - 0.8 9.8 18.5 1.9 8.6 18.5 1.6 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 ABC_export PF16962.3 001101651.1_21025001_3 - 1.6 7.0 7.7 2.9 6.1 7.7 1.5 1 0 0 1 1 1 0 Putative ABC exporter OAD_gamma PF04277.11 001101651.1_21025001_3 - 3.8 8.0 6.2 9.9 6.7 6.2 1.8 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Tektin PF03148.12 001075783.2_06523001_2 - 6.7e-147 489.1 33.5 7.6e-147 488.9 33.5 1.0 1 0 0 1 1 1 1 Tektin family DUF1664 PF07889.10 001075783.2_06523001_2 - 0.081 12.8 12.6 0.46 10.4 0.4 3.6 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) SNARE PF05739.17 001075783.2_06523001_2 - 0.92 9.4 5.7 0.53 10.2 0.2 3.1 4 0 0 4 4 4 0 SNARE domain DUF948 PF06103.9 001075783.2_06523001_2 - 1.8 8.8 7.9 14 5.9 0.6 3.7 3 2 0 3 3 3 0 Bacterial protein of unknown function (DUF948) COG5 PF10392.7 001075783.2_06523001_2 - 2.1 8.4 16.5 0.26 11.3 1.7 3.3 2 2 1 3 3 3 0 Golgi transport complex subunit 5 Phasin PF05597.9 001075783.2_06523001_2 - 5.1 7.0 10.9 0.63 10.0 2.1 2.5 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF1515 PF07439.9 001075783.2_06523001_2 - 8.8 6.2 8.5 7.4 6.5 0.5 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1515) SIMPL PF04402.12 001110093.1_06522001_1 - 5.8e-27 95.3 0.1 7.2e-27 95.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF541) Transglut_C PF00927.20 001110093.1_06522001_1 - 0.043 13.8 0.0 0.083 12.9 0.0 1.4 1 0 0 1 1 1 0 Transglutaminase family, C-terminal ig like domain Pro_isomerase PF00160.19 001001597.1_06522001_1 - 7.9e-47 159.3 0.2 1e-46 159.0 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD adh_short PF00106.23 001075726.1_06523001_1 - 8.1e-47 159.1 0.1 1e-46 158.8 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001075726.1_06523001_1 - 3.2e-27 95.5 0.0 4.6e-27 95.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Peptidase_S49 PF01343.16 001075726.1_06523001_1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Peptidase family S49 DUF4200 PF13863.4 001101166.2_06523001_3 - 8.1e-28 97.1 29.0 8.1e-28 97.1 29.0 3.2 3 0 0 3 3 3 2 Domain of unknown function (DUF4200) DUF2780 PF11075.6 001101166.2_06523001_3 - 0.024 14.7 0.4 0.067 13.2 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function VcgC/VcgE (DUF2780) EVE PF01878.16 001076422.2_06522001_2 - 2.2e-35 121.7 0.1 3.9e-35 120.8 0.1 1.4 1 0 0 1 1 1 1 EVE domain SARG PF15385.4 001102526.1_06528001_1 - 2e-11 43.7 8.3 2.1e-08 33.8 0.2 3.3 2 1 1 3 3 3 2 Specifically androgen-regulated gene protein Peptidase_M10 PF00413.22 001111302.1_21025001_1 - 1.1e-63 213.6 0.0 3.8e-63 211.9 0.0 1.8 1 1 0 1 1 1 1 Matrixin fn2 PF00040.17 001111302.1_21025001_1 - 6.3e-56 186.3 37.1 2.2e-19 69.3 5.4 3.8 3 0 0 3 3 3 3 Fibronectin type II domain Hemopexin PF00045.17 001111302.1_21025001_1 - 5.3e-27 93.4 8.3 2.6e-08 33.5 0.1 4.5 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.16 001111302.1_21025001_1 - 6.1e-10 39.0 0.1 1.3e-09 38.0 0.1 1.6 1 0 0 1 1 1 1 Putative peptidoglycan binding domain PT PF04886.10 001111302.1_21025001_1 - 3.3e-05 23.2 19.3 3.3e-05 23.2 19.3 3.0 3 1 1 4 4 4 1 PT repeat Astacin PF01400.22 001111302.1_21025001_1 - 0.015 14.7 0.2 3.5 7.1 0.1 2.6 3 0 0 3 3 3 0 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.4 001111302.1_21025001_1 - 0.044 14.2 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 001111302.1_21025001_1 - 0.056 12.9 0.0 0.095 12.2 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.3 001111302.1_21025001_1 - 0.06 12.4 0.0 0.099 11.7 0.0 1.3 1 0 0 1 1 1 0 Met-zincin TRAP-delta PF05404.10 001038503.2_06522001_2 - 1.7e-67 225.8 0.1 2.1e-67 225.6 0.1 1.0 1 0 0 1 1 1 1 Translocon-associated protein, delta subunit precursor (TRAP-delta) Phtf-FEM1B_bdg PF12129.6 001076077.1_06526001_2 - 1.6e-68 229.3 3.8 3.7e-68 228.1 3.8 1.7 1 0 0 1 1 1 1 Male germ-cell putative homeodomain transcription factor RNA_pol_Rpc4 PF05132.12 001001136.3_06525001_1 - 0.041 14.2 14.3 0.065 13.5 14.3 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 RNA_pol_Rpc4 PF05132.12 001001136.3_06525001_2 - 0.0051 17.1 10.0 0.0074 16.6 10.0 1.2 1 0 0 1 1 1 1 RNA polymerase III RPC4 PWWP PF00855.15 001001136.3_06525001_3 - 2.1e-09 37.6 0.0 2.1e-09 37.6 0.0 3.5 2 1 0 2 2 2 1 PWWP domain RNA_pol_Rpc4 PF05132.12 001001136.3_06525001_3 - 0.0054 17.1 8.8 0.0054 17.1 8.8 2.4 2 0 0 2 2 2 1 RNA polymerase III RPC4 Connexin PF00029.17 001001136.3_06525001_3 - 0.24 11.0 11.3 0.37 10.4 11.3 1.3 1 0 0 1 1 1 0 Connexin DUF1394 PF07159.10 001075172.1_06524001_1 - 5.8e-147 488.7 1.7 6.8e-147 488.4 1.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) Thioredoxin PF00085.18 001076149.1_06523001_2 - 5.7e-08 32.5 0.0 1.1e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.14 001076149.1_06523001_2 - 1.3e-05 24.1 0.4 1.9e-05 23.6 0.4 1.2 1 0 0 1 1 1 1 Phosducin DUF342 PF03961.11 001076149.1_06523001_2 - 0.92 7.9 5.4 1.2 7.5 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Amidohydro_2 PF04909.12 001075694.1_06523001_2 - 1.6e-70 238.1 0.0 1.8e-70 237.9 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase La PF05383.15 001099205.1_06525001_3 - 1e-20 73.4 0.2 1.8e-20 72.6 0.2 1.4 1 0 0 1 1 1 1 La domain SUZ-C PF12901.5 001099205.1_06525001_3 - 2.3e-07 30.6 0.1 4.6e-07 29.6 0.1 1.5 1 0 0 1 1 1 1 SUZ-C motif RRM_1 PF00076.20 001099205.1_06525001_3 - 0.052 13.2 0.1 9.5 6.0 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pex19 PF04614.10 001034540.2_06524001_1 - 7.7e-56 189.5 6.0 1.2e-55 188.8 6.0 1.3 1 0 0 1 1 1 1 Pex19 protein family Rod-binding PF10135.7 001034540.2_06524001_1 - 0.061 13.8 0.2 0.17 12.3 0.2 1.7 1 0 0 1 1 1 0 Rod binding protein Peptidase_U57 PF05582.10 001105467.1_06523001_1 - 1.6 7.8 6.7 2 7.4 6.7 1.1 1 0 0 1 1 1 0 YabG peptidase U57 Folate_carrier PF01770.16 001105467.1_06523001_1 - 9.1 4.8 5.3 11 4.4 5.3 1.0 1 0 0 1 1 1 0 Reduced folate carrier EOS1 PF12326.6 001105467.1_06523001_2 - 0.086 12.6 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 N-glycosylation protein HLH PF00010.24 001105467.1_06523001_3 - 1.2e-14 53.8 2.7 2e-14 53.1 1.8 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.11 001105467.1_06523001_3 - 5.2e-08 32.8 0.1 1e-07 31.9 0.1 1.5 1 0 0 1 1 1 1 Hairy Orange SR-25 PF10500.7 001105467.1_06523001_3 - 2.8 7.4 36.0 4.6 6.6 36.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Med7 PF05983.9 001079583.2_06523001_2 - 2.1e-43 148.4 7.6 4.6e-43 147.3 7.6 1.5 1 1 0 1 1 1 1 MED7 protein DotU PF09850.7 001079583.2_06523001_2 - 0.003 17.2 2.3 0.12 12.0 0.1 2.1 2 0 0 2 2 2 2 Type VI secretion system protein DotU Peptidase_S8 PF00082.20 001099034.2_06529001_1 - 3.5e-111 371.1 2.0 5.6e-111 370.4 2.0 1.3 1 0 0 1 1 1 1 Subtilase family TPPII PF12580.6 001099034.2_06529001_1 - 9.6e-78 259.9 0.0 1.8e-77 259.0 0.0 1.5 1 0 0 1 1 1 1 Tripeptidyl peptidase II TPPII_N PF12583.6 001099034.2_06529001_1 - 0.038 14.4 0.2 0.086 13.3 0.2 1.5 1 0 0 1 1 1 0 Tripeptidyl peptidase II N terminal RRM_1 PF00076.20 001110081.1_06527001_1 - 4e-09 36.0 0.1 0.00015 21.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MRP-S33 PF08293.9 001037605.2_06522001_2 - 5.5e-21 74.5 1.1 8.5e-21 73.8 1.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 Integrin_alpha2 PF08441.10 198221.2_06527001_1 - 8.5e-38 130.3 0.0 1.1e-37 129.9 0.0 1.2 1 0 0 1 1 1 1 Integrin alpha VWA PF00092.26 198221.2_06527001_1 - 1.1e-29 103.8 0.9 1.7e-29 103.2 0.9 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain FG-GAP PF01839.21 198221.2_06527001_1 - 3.1e-20 71.8 4.6 1.8e-07 31.0 0.2 3.8 3 0 0 3 3 3 3 FG-GAP repeat VWA_2 PF13519.4 198221.2_06527001_1 - 8.5e-10 39.1 0.3 2.7e-08 34.3 0.0 2.3 2 0 0 2 2 2 1 von Willebrand factor type A domain VCBS PF13517.4 198221.2_06527001_1 - 1.1e-06 29.0 0.8 0.00027 21.3 0.1 2.8 1 1 2 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.18 198221.2_06527001_1 - 0.00014 21.5 0.4 0.00028 20.5 0.4 1.6 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region FG-GAP_2 PF14312.4 198221.2_06527001_1 - 0.037 14.2 9.6 0.38 10.9 0.0 3.7 4 0 0 4 4 4 0 FG-GAP repeat GIDA PF01134.20 001076069.1_06525001_1 - 8.6e-152 505.6 0.0 1.1e-151 505.2 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.4 001076069.1_06525001_1 - 2.2e-59 200.5 0.1 4e-59 199.6 0.1 1.4 1 0 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.5 001076069.1_06525001_1 - 1.5e-06 27.7 0.1 2.1e-06 27.2 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.12 001076069.1_06525001_1 - 1.8e-06 27.3 0.1 4.3e-06 26.1 0.1 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 001076069.1_06525001_1 - 1.3e-05 24.3 3.0 0.00012 21.1 1.5 2.1 2 0 0 2 2 2 1 FAD binding domain AlaDh_PNT_C PF01262.19 001076069.1_06525001_1 - 0.00044 19.5 0.1 0.0009 18.5 0.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.25 001076069.1_06525001_1 - 0.0048 17.3 0.1 0.013 15.9 0.1 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.12 001076069.1_06525001_1 - 0.0056 15.3 2.2 0.014 14.0 0.3 2.4 3 0 0 3 3 3 1 HI0933-like protein PQ-loop PF04193.12 001101878.1_06524001_1 - 4.1e-06 26.3 5.4 3.6e-05 23.3 0.9 2.5 2 0 0 2 2 2 2 PQ loop repeat Glyco_transf_29 PF00777.16 001002892.2_06528001_3 - 6e-82 274.9 0.0 8.1e-82 274.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) G_glu_transpept PF01019.19 001002892.2_06528001_3 - 0.012 14.3 0.0 0.017 13.8 0.0 1.1 1 0 0 1 1 1 0 Gamma-glutamyltranspeptidase Pkinase PF00069.23 001102021.2_06526001_1 - 1.1e-11 44.5 0.0 1.8e-11 43.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001102021.2_06526001_1 - 2.9e-08 33.2 0.0 1.9e-07 30.5 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase HEAT PF02985.20 001102021.2_06526001_1 - 3e-08 33.1 0.0 0.018 15.1 0.0 4.7 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.4 001102021.2_06526001_1 - 0.023 15.0 0.0 0.9 9.9 0.0 3.6 4 0 0 4 4 4 0 HEAT-like repeat Vac14_Fab1_bd PF12755.5 001102021.2_06526001_1 - 0.12 12.8 0.1 21 5.7 0.0 3.2 2 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region DUF3385 PF11865.6 001102021.2_06526001_1 - 0.15 11.7 0.0 1.7 8.3 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3385) FRG1 PF06229.10 001075566.1_06523001_2 - 5e-80 267.6 1.7 7.6e-80 267.0 0.2 1.8 2 0 0 2 2 2 1 FRG1-like domain Fascin PF06268.11 001075566.1_06523001_2 - 8.2e-07 29.1 0.0 2e-06 27.9 0.0 1.8 1 1 0 1 1 1 1 Fascin domain DUF569 PF04601.11 001075566.1_06523001_2 - 0.0043 16.6 0.0 0.078 12.5 0.0 2.8 1 1 1 2 2 2 1 Domain of unknown function (DUF569) DUF2235 PF09994.7 001075566.1_06523001_2 - 0.0095 15.2 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) DUF525 PF04379.12 001099062.1_06525001_3 - 5.7e-29 100.1 0.1 1.2e-28 99.1 0.1 1.5 1 0 0 1 1 1 1 ApaG domain SMI1_KNR4 PF09346.8 001099062.1_06525001_3 - 1.5e-13 51.2 0.8 5e-13 49.5 0.0 2.1 2 0 0 2 2 2 1 SMI1 / KNR4 family (SUKH-1) F-box-like PF12937.5 001099062.1_06525001_3 - 6.3e-09 35.4 4.2 2.5e-08 33.5 4.3 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.31 001099062.1_06525001_3 - 1.5e-07 30.9 5.6 3.6e-07 29.7 5.6 1.7 1 0 0 1 1 1 1 F-box domain SUKH_6 PF14568.4 001099062.1_06525001_3 - 0.0057 17.0 0.4 0.014 15.7 0.0 2.0 2 1 0 2 2 2 1 SMI1-KNR4 cell-wall SUKH_5 PF14567.4 001099062.1_06525001_3 - 0.042 13.5 0.0 0.09 12.4 0.0 1.5 1 0 0 1 1 1 0 SMI1-KNR4 cell-wall Sigma70_ner PF04546.11 001099062.1_06525001_3 - 1.4 8.7 10.7 0.78 9.5 5.6 2.1 2 0 0 2 2 2 0 Sigma-70, non-essential region Cwf_Cwc_15 PF04889.10 001099062.1_06525001_3 - 2 7.9 9.8 3.2 7.3 9.8 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RXT2_N PF08595.9 001099062.1_06525001_3 - 6.3 6.7 6.5 11 5.9 6.5 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal Asp PF00026.21 176620.2_06523001_2 - 6.1e-96 321.4 0.0 7.5e-96 321.1 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 176620.2_06523001_2 - 9.6e-15 55.2 1.5 4.7e-12 46.4 1.5 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 176620.2_06523001_2 - 3.5e-13 49.0 1.8 6.3e-13 48.2 1.8 1.4 1 0 0 1 1 1 1 A1 Propeptide Asp_protease_2 PF13650.4 176620.2_06523001_2 - 0.022 15.3 0.0 0.23 12.0 0.0 2.4 1 1 0 1 1 1 0 Aspartyl protease RGS PF00615.17 001081939.1_21022001_2 - 8.3e-38 129.2 3.0 1.2e-37 128.7 3.0 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF1669 PF07894.10 001081939.1_21022001_2 - 0.047 13.1 0.1 0.06 12.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1669) Herpes_UL92 PF03048.12 001081939.1_21022001_2 - 0.087 12.5 0.1 0.13 11.9 0.1 1.2 1 0 0 1 1 1 0 UL92 family Prenyltrans PF00432.19 001015560.1_06523001_2 - 2.3e-41 139.1 6.2 1.5e-09 37.2 0.0 6.2 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Trp_leader2 PF08056.9 001015560.1_06523001_2 - 0.22 11.4 0.9 0.43 10.5 0.9 1.4 1 0 0 1 1 1 0 Tryptophan operon leader peptide SR-25 PF10500.7 001105475.2_06524001_1 - 0.78 9.2 12.8 1.1 8.7 12.8 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein WD40 PF00400.30 001105475.2_06524001_2 - 7.5e-61 200.5 19.9 8.7e-10 38.9 0.2 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001105475.2_06524001_2 - 1.2e-25 89.5 1.7 7.4e-05 22.8 0.1 6.3 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 001105475.2_06524001_2 - 1.9e-13 49.8 4.8 0.0025 16.4 0.2 4.6 1 1 4 5 5 5 4 Nucleoporin Nup120/160 eIF2A PF08662.9 001105475.2_06524001_2 - 2.3e-12 47.0 0.1 1.2e-05 25.1 0.0 3.6 1 1 4 5 5 5 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.3 001105475.2_06524001_2 - 1.1e-05 24.8 0.2 0.0095 15.2 0.0 3.1 1 1 1 3 3 3 2 WD40-like domain Ge1_WD40 PF16529.3 001105475.2_06524001_2 - 1.6e-05 23.9 4.9 0.064 12.1 0.8 3.8 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.3 001105475.2_06524001_2 - 6e-05 22.0 1.6 3.7 6.2 0.0 4.0 1 1 2 4 4 4 3 Partner and localizer of BRCA2 WD40 domain Frtz PF11768.6 001105475.2_06524001_2 - 0.0015 16.8 0.0 0.038 12.2 0.0 2.2 1 1 1 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz AP3D1 PF06375.9 001105475.2_06524001_2 - 0.12 12.5 9.0 0.18 11.9 9.0 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Hira PF07569.9 001105475.2_06524001_2 - 0.16 11.5 1.5 51 3.4 0.0 3.9 3 1 2 5 5 5 0 TUP1-like enhancer of split Nucleoporin_N PF08801.9 001105475.2_06524001_2 - 0.28 9.7 3.9 0.5 8.9 1.3 2.5 1 1 1 2 2 2 0 Nup133 N terminal like OAS1_C PF10421.7 178108.2_06523001_1 - 1.6e-84 281.9 1.8 2.4e-84 281.3 1.8 1.2 1 0 0 1 1 1 1 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus NTP_transf_2 PF01909.21 178108.2_06523001_1 - 8.8e-09 35.4 0.0 3.3e-08 33.6 0.0 1.9 2 0 0 2 2 2 1 Nucleotidyltransferase domain DZF PF07528.12 178108.2_06523001_1 - 0.0065 16.0 0.0 0.047 13.2 0.0 2.0 1 1 0 1 1 1 1 DZF domain Nrap PF03813.12 178108.2_06523001_1 - 0.11 10.0 0.1 0.17 9.4 0.1 1.2 1 0 0 1 1 1 0 Nrap protein DUF677 PF05055.10 001015620.1_06523001_1 - 0.1 11.3 5.3 0.13 11.0 5.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF677) TYW3 PF02676.12 001015620.1_06523001_3 - 1.2e-56 191.3 0.8 2.2e-56 190.5 0.8 1.4 1 0 0 1 1 1 1 Methyltransferase TYW3 DUF3524 PF12038.6 001076035.1_06525001_1 - 4.3e-71 238.0 0.1 6.1e-71 237.5 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3524) TPR_1 PF00515.26 001101982.1_06523001_1 - 9e-18 63.2 0.6 1.7e-07 30.6 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.15 001101982.1_06523001_1 - 4.3e-14 51.3 3.7 1.1e-05 25.1 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.4 001101982.1_06523001_1 - 2.8e-09 36.9 5.8 0.002 18.7 0.2 3.5 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_9 PF13371.4 001101982.1_06523001_1 - 5.7e-08 32.7 5.7 1.1e-06 28.6 0.3 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.4 001101982.1_06523001_1 - 2.6e-07 30.2 0.0 0.00035 20.4 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.4 001101982.1_06523001_1 - 8.3e-07 29.5 5.6 0.0027 18.2 0.5 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.4 001101982.1_06523001_1 - 9.5e-07 28.9 1.1 0.0059 17.0 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.4 001101982.1_06523001_1 - 2.2e-06 27.9 0.4 0.001 19.4 0.1 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.4 001101982.1_06523001_1 - 1e-05 25.6 1.4 0.0047 17.1 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.4 001101982.1_06523001_1 - 1.2e-05 24.9 0.0 0.91 9.6 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.4 001101982.1_06523001_1 - 9.6e-05 21.9 0.0 0.017 14.7 0.0 2.6 2 1 0 2 2 2 1 TPR repeat TPR_17 PF13431.4 001101982.1_06523001_1 - 0.00043 20.3 0.1 0.081 13.2 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 001101982.1_06523001_1 - 0.0015 18.5 0.1 0.021 14.8 0.0 2.3 1 1 1 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat BTAD PF03704.15 001101982.1_06523001_1 - 0.0035 17.7 3.1 0.66 10.3 0.2 2.4 1 1 0 2 2 2 2 Bacterial transcriptional activator domain ANAPC3 PF12895.5 001101982.1_06523001_1 - 0.037 14.1 0.1 0.065 13.3 0.1 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.12 001101982.1_06523001_1 - 0.47 11.1 12.5 11 6.9 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.4 001101982.1_06523001_1 - 4.6 7.1 6.2 14 5.6 0.1 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat Phosducin PF02114.14 001075645.1_06524001_1 - 1.1e-16 60.5 0.1 1.6e-16 59.9 0.1 1.2 1 0 0 1 1 1 1 Phosducin UPF0175 PF03683.11 001075645.1_06524001_1 - 0.00087 18.8 2.4 0.028 14.0 0.3 2.7 1 1 2 3 3 3 2 Uncharacterised protein family (UPF0175) PhdYeFM_antitox PF02604.17 001075645.1_06524001_1 - 0.052 13.2 0.1 0.2 11.3 0.0 1.9 2 0 0 2 2 2 0 Antitoxin Phd_YefM, type II toxin-antitoxin system AA_permease_2 PF13520.4 001035054.2_06524001_3 - 5.7e-61 206.5 47.1 8.3e-61 205.9 47.1 1.3 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.19 001035054.2_06524001_3 - 7.5e-24 84.0 43.5 9.6e-24 83.7 43.5 1.1 1 0 0 1 1 1 1 Amino acid permease SirB PF04247.10 001035054.2_06524001_3 - 0.013 15.4 0.5 0.013 15.4 0.5 2.8 2 1 0 2 2 2 0 Invasion gene expression up-regulator, SirB 2OG-FeII_Oxy PF03171.18 001101149.1_06529001_1 - 1.2e-05 25.6 0.0 2.7e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.4 001101149.1_06529001_1 - 0.00024 21.8 0.0 0.00056 20.6 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Anp1 PF03452.12 001101149.1_06529001_1 - 0.029 13.7 0.0 0.029 13.7 0.0 3.0 3 1 0 4 4 4 0 Anp1 Glycos_transf_2 PF00535.24 001101149.1_06529001_1 - 0.037 13.7 0.0 0.088 12.5 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 2 Mob1_phocein PF03637.15 001076338.1_06524001_3 - 1.4e-83 278.8 0.2 2e-83 278.3 0.2 1.2 1 0 0 1 1 1 1 Mob1/phocein family Fibin PF15819.3 001099443.1_21024001_2 - 2.1e-104 347.2 1.7 2.5e-104 346.9 1.7 1.1 1 0 0 1 1 1 1 Fin bud initiation factor homologue ERp29_N PF07912.11 001076271.1_06523001_2 - 2.4e-55 185.9 0.2 3.5e-55 185.4 0.2 1.2 1 0 0 1 1 1 1 ERp29, N-terminal domain ERp29 PF07749.10 001076271.1_06523001_2 - 4.2e-24 85.1 0.1 7.1e-24 84.4 0.1 1.4 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain LRR_8 PF13855.4 001080729.1_06525001_3 - 2e-28 97.8 8.8 3.3e-14 52.2 0.4 2.6 1 1 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.5 001080729.1_06525001_3 - 5.1e-14 52.0 3.1 0.00083 19.5 1.0 3.6 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) I-set PF07679.14 001080729.1_06525001_3 - 9.7e-08 31.8 0.0 1.9e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain LRR_5 PF13306.4 001080729.1_06525001_3 - 6.2e-07 29.3 0.0 8.5e-05 22.4 0.0 1.7 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001080729.1_06525001_3 - 2.9e-06 26.8 0.1 0.0039 16.6 0.0 2.1 1 1 2 3 3 3 3 Leucine-rich repeat Ig_3 PF13927.4 001080729.1_06525001_3 - 3.9e-06 27.2 0.0 8.9e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001080729.1_06525001_3 - 0.00081 19.4 0.0 0.0022 18.0 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain LRR_6 PF13516.4 001080729.1_06525001_3 - 0.015 15.2 8.2 0.39 10.8 0.7 4.7 5 0 0 5 5 5 0 Leucine Rich repeat TPKR_C2 PF16920.3 001080729.1_06525001_3 - 0.077 13.0 0.1 0.2 11.7 0.1 1.7 1 0 0 1 1 1 0 Tyrosine-protein kinase receptor C2 Ig-like domain LRRCT PF01463.22 001080729.1_06525001_3 - 0.11 13.0 2.7 0.15 12.5 0.1 2.8 3 0 0 3 3 2 0 Leucine rich repeat C-terminal domain Ig_2 PF13895.4 001080729.1_06525001_3 - 0.14 12.4 0.0 0.84 9.9 0.0 2.3 1 1 0 1 1 1 0 Immunoglobulin domain LRR_1 PF00560.31 001080729.1_06525001_3 - 0.16 12.4 9.0 9 7.1 0.9 5.9 4 2 0 4 4 4 0 Leucine Rich Repeat RnaseA PF00074.18 001081899.1_21021001_1 - 2.4e-32 111.8 0.3 2.8e-32 111.7 0.3 1.0 1 0 0 1 1 1 1 Pancreatic ribonuclease Tmemb_55A PF09788.7 001040594.2_06523001_1 - 1.4e-102 341.9 12.1 1.7e-102 341.6 12.1 1.0 1 0 0 1 1 1 1 Transmembrane protein 55A zf-BED PF02892.13 001040594.2_06523001_1 - 0.12 12.3 7.7 1.9 8.5 0.0 3.5 3 1 1 4 4 4 0 BED zinc finger zinc_ribbon_4 PF13717.4 001040594.2_06523001_1 - 0.73 9.7 0.0 0.73 9.7 0.0 4.5 4 1 0 4 4 4 0 zinc-ribbon domain C1_1 PF00130.20 001040594.2_06523001_1 - 0.75 9.6 12.0 1.8 8.4 0.9 3.0 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PDZ PF00595.22 001034611.2_06525001_1 - 9.8e-58 192.3 7.5 6e-14 52.0 0.3 4.2 4 0 0 4 4 4 4 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001034611.2_06525001_1 - 4e-30 103.8 13.2 3.4e-08 33.6 0.2 4.3 4 0 0 4 4 4 4 PDZ domain GRASP55_65 PF04495.12 001034611.2_06525001_1 - 2.1e-09 37.7 0.2 0.037 14.2 0.0 4.0 4 0 0 4 4 4 3 GRASP55/65 PDZ-like domain Tricorn_PDZ PF14685.4 001034611.2_06525001_1 - 1.2e-05 25.1 6.4 0.0078 16.1 0.1 4.0 4 0 0 4 4 4 2 Tricorn protease PDZ domain DUF4265 PF14085.4 001034611.2_06525001_1 - 0.019 14.8 1.3 2.4 8.0 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4265) DUF3394 PF11874.6 001034611.2_06525001_1 - 0.03 13.8 0.6 8.3 5.9 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3394) ThiS PF02597.18 001034611.2_06525001_1 - 0.039 14.5 0.8 5.2 7.6 0.0 3.4 4 0 0 4 4 4 0 ThiS family MHC_I PF00129.16 001099765.1_21023001_1 - 6.9e-93 309.0 0.3 1e-92 308.5 0.3 1.3 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001099765.1_21023001_1 - 2.3e-16 59.9 0.0 4.6e-16 58.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001099765.1_21023001_1 - 2e-10 40.3 11.6 4e-10 39.3 11.6 1.5 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 001099765.1_21023001_1 - 2.3e-05 24.8 0.5 0.11 13.0 0.0 2.5 1 1 1 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001099765.1_21023001_1 - 0.00016 21.5 0.1 0.00031 20.6 0.1 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001099765.1_21023001_1 - 0.018 15.1 0.1 0.035 14.1 0.1 1.5 1 0 0 1 1 1 0 Immunoglobulin domain Ig_2 PF13895.4 001099765.1_21023001_1 - 0.02 15.1 0.0 0.056 13.7 0.0 1.8 1 1 0 1 1 1 0 Immunoglobulin domain PepSY_TM PF03929.14 001099765.1_21023001_1 - 1.3 8.2 4.5 3.9 6.6 0.6 2.1 1 1 1 2 2 2 0 PepSY-associated TM region bZIP_2 PF07716.13 001099765.1_21023001_3 - 0.013 15.4 1.1 0.028 14.4 1.1 1.4 1 0 0 1 1 1 0 Basic region leucine zipper CBFB_NFYA PF02045.13 001014956.1_06524001_2 - 4.8e-27 94.3 8.9 7.9e-27 93.6 8.9 1.3 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B 7tm_1 PF00001.19 001081779.1_21023001_1 - 3.5e-78 262.4 12.6 4.4e-78 262.1 12.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001081779.1_21023001_1 - 4.5e-11 42.5 9.9 4.6e-10 39.2 9.9 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001081779.1_21023001_1 - 7.8e-06 25.3 5.3 7.8e-06 25.3 5.3 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001081779.1_21023001_1 - 4.5e-05 23.2 9.4 0.00071 19.3 4.5 2.3 2 1 0 2 2 2 2 Olfactory receptor DUF1761 PF08570.8 001081779.1_21023001_1 - 5.8 7.1 10.0 6 7.0 0.1 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1761) Pkinase_Tyr PF07714.15 001014964.1_06525001_3 - 2.4e-60 203.9 0.0 3.2e-60 203.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001014964.1_06525001_3 - 3.3e-55 187.2 0.0 4.7e-55 186.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain RBD PF02196.13 001014964.1_06525001_3 - 5.9e-24 83.8 0.1 1e-23 83.1 0.1 1.4 1 0 0 1 1 1 1 Raf-like Ras-binding domain C1_1 PF00130.20 001014964.1_06525001_3 - 1.6e-10 40.5 10.2 2.8e-10 39.8 10.2 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.4 001014964.1_06525001_3 - 7.6e-08 31.9 0.0 1.1e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like zf-RING-like PF08746.9 001014964.1_06525001_3 - 0.0031 17.7 4.7 0.0076 16.4 4.7 1.6 1 0 0 1 1 1 1 RING-like domain APH PF01636.21 001014964.1_06525001_3 - 0.013 15.3 0.5 0.21 11.4 0.1 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family TUG-UBL1 PF11470.6 001014964.1_06525001_3 - 0.06 13.5 0.1 0.19 11.9 0.0 1.8 2 0 0 2 2 2 0 TUG ubiquitin-like domain Kdo PF06293.12 001014964.1_06525001_3 - 0.13 11.5 0.2 0.22 10.7 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RING_2 PF13639.4 001014964.1_06525001_3 - 7.7 6.7 8.6 19 5.5 8.6 1.6 1 0 0 1 1 1 0 Ring finger domain Phospholip_A2_1 PF00068.17 001100113.2_21021001_2 - 2.8e-36 124.2 15.8 3.5e-36 123.8 15.8 1.1 1 0 0 1 1 1 1 Phospholipase A2 Phospholip_A2_2 PF05826.10 001100113.2_21021001_2 - 0.14 12.2 15.1 7.4 6.7 15.1 2.3 1 1 0 1 1 1 0 Phospholipase A2 FCH PF00611.21 001046468.1_06527001_1 - 8.6e-16 57.8 0.2 8.6e-16 57.8 0.2 2.5 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.26 001046468.1_06527001_1 - 1.3e-15 56.5 0.1 2.4e-15 55.7 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 001046468.1_06527001_1 - 2.9e-15 55.7 1.3 8.8e-15 54.2 0.3 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.15 001046468.1_06527001_1 - 4.7e-07 29.3 0.0 9.7e-07 28.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain NPF PF16601.3 001046468.1_06527001_1 - 0.0018 18.7 6.6 0.0018 18.7 6.6 1.7 2 0 0 2 2 2 1 Rabosyn-5 repeating NPF sequence-motif SH3BP5 PF05276.12 001046468.1_06527001_1 - 0.1 12.3 12.3 0.11 12.2 11.3 1.5 1 1 0 1 1 1 0 SH3 domain-binding protein 5 (SH3BP5) Cyclin_N PF00134.21 001015665.1_06526001_1 - 2.8e-41 140.2 2.2 5.9e-41 139.1 2.2 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 001015665.1_06526001_1 - 2.8e-21 75.7 0.2 5.1e-21 74.8 0.2 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain Innexin PF00876.16 001046140.1_06525001_1 - 0.11 11.6 0.1 0.16 11.1 0.1 1.1 1 0 0 1 1 1 0 Innexin OAD_gamma PF04277.11 001046140.1_06525001_1 - 6.6 7.3 6.4 11 6.6 6.4 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain GIT_CC PF16559.3 001046140.1_06525001_2 - 0.038 13.9 5.6 2.4 8.1 0.8 3.1 1 1 2 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor APG6 PF04111.10 001046140.1_06525001_2 - 0.082 12.2 6.4 0.17 11.1 6.4 1.6 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF3508 PF12018.6 001046140.1_06525001_2 - 0.13 11.6 6.8 0.21 10.9 6.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3508) PilJ PF13675.4 001046140.1_06525001_2 - 0.15 12.0 5.0 0.14 12.1 1.4 2.3 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Syntaxin-6_N PF09177.9 001046140.1_06525001_2 - 0.61 10.6 7.0 1.1 9.8 6.2 1.9 1 1 1 2 2 2 0 Syntaxin 6, N-terminal CorA PF01544.16 001046140.1_06525001_2 - 2.7 7.1 6.5 2.8 7.1 5.5 1.4 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF4404 PF14357.4 001046140.1_06525001_2 - 6.8 7.3 8.6 1.6 9.3 4.2 2.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4404) Fib_alpha PF08702.8 001046140.1_06525001_2 - 7.5 6.6 14.3 2.9 7.9 10.0 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family V_ATPase_I PF01496.17 001046140.1_06525001_2 - 7.6 4.2 8.2 13 3.4 8.2 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ets PF00178.20 001081542.1_06525001_2 - 6.3e-34 116.2 3.0 1e-33 115.5 3.0 1.3 1 0 0 1 1 1 1 Ets-domain Erg28 PF03694.11 001035423.2_06522001_3 - 4.5e-37 126.7 1.5 6.9e-37 126.1 1.5 1.3 1 0 0 1 1 1 1 Erg28 like protein PUB PF09409.8 001045986.1_06523001_1 - 1.9e-23 82.1 0.0 4.3e-23 80.9 0.0 1.6 1 0 0 1 1 1 1 PUB domain UBX PF00789.18 001045986.1_06523001_1 - 1.1e-07 31.8 0.0 2.1e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 UBX domain DUF3704 PF12488.6 001077934.1_06527001_1 - 0.006 16.1 1.9 0.015 14.8 1.9 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3704) FtsJ PF01728.17 001077934.1_06527001_3 - 8.1e-68 227.9 0.0 1.2e-67 227.4 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Ig_2 PF13895.4 001082527.1_21023001_2 - 3e-16 59.4 4.2 1.6e-09 37.8 0.0 2.8 3 0 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.4 001082527.1_21023001_2 - 6.1e-08 33.0 0.2 0.0071 16.8 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001082527.1_21023001_2 - 9e-06 25.6 0.1 7.2e-05 22.7 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain HAGH_C PF16123.3 001035274.1_06523001_3 - 1.8e-27 95.5 0.4 2.8e-27 94.9 0.4 1.3 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.25 001035274.1_06523001_3 - 6.5e-12 45.7 4.7 1.5e-09 38.0 4.7 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.5 001035274.1_06523001_3 - 0.0006 19.3 0.4 0.0015 18.0 0.4 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain zf-DHHC PF01529.18 001076388.2_06524001_2 - 4.7e-38 130.2 17.2 4.7e-38 130.2 17.2 2.6 3 0 0 3 3 3 2 DHHC palmitoyltransferase Spt4 PF06093.11 001076388.2_06524001_2 - 0.21 11.6 5.0 0.42 10.6 5.0 1.5 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger ERM PF00769.17 001015539.1_06522001_1 - 0.001 18.8 7.8 0.0013 18.5 7.8 1.1 1 0 0 1 1 1 1 Ezrin/radixin/moesin family APG6 PF04111.10 001015539.1_06522001_1 - 0.0019 17.5 11.1 0.0025 17.1 11.1 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 CCDC154 PF15450.4 001015539.1_06522001_1 - 0.0024 16.4 5.8 0.0031 16.0 5.8 1.2 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 154 Bacillus_HBL PF05791.9 001015539.1_06522001_1 - 0.026 14.1 3.4 0.035 13.7 3.4 1.1 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) ADIP PF11559.6 001015539.1_06522001_1 - 0.03 14.3 12.3 0.046 13.7 12.3 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Suppressor_APC PF11414.6 001015539.1_06522001_1 - 0.032 14.1 4.0 0.048 13.6 4.0 1.3 1 0 0 1 1 1 0 Adenomatous polyposis coli tumour suppressor protein DUF1664 PF07889.10 001015539.1_06522001_1 - 0.033 14.0 2.9 0.045 13.6 2.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF3086 PF11285.6 001015539.1_06522001_1 - 0.054 12.5 2.3 0.066 12.2 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3086) DUF1241 PF06840.9 001015539.1_06522001_1 - 0.057 12.9 1.6 0.076 12.5 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1241) GAS PF13851.4 001015539.1_06522001_1 - 0.066 12.5 12.5 0.22 10.7 8.8 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Flagellar_rod PF05149.10 001015539.1_06522001_1 - 0.075 12.4 11.5 0.091 12.1 11.5 1.0 1 0 0 1 1 1 0 Paraflagellar rod protein Golgin_A5 PF09787.7 001015539.1_06522001_1 - 0.081 12.2 9.5 0.11 11.8 9.5 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 HemX PF04375.12 001015539.1_06522001_1 - 0.082 12.0 7.6 0.11 11.6 7.6 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase ZapB PF06005.10 001015539.1_06522001_1 - 0.1 12.9 10.1 0.2 12.0 10.1 1.5 1 0 0 1 1 1 0 Cell division protein ZapB DUF724 PF05266.12 001015539.1_06522001_1 - 0.11 12.1 6.2 0.16 11.7 6.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Spc7 PF08317.9 001015539.1_06522001_1 - 0.13 11.0 14.1 0.17 10.6 14.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein HALZ PF02183.16 001015539.1_06522001_1 - 0.16 12.1 6.1 0.11 12.6 3.9 1.9 1 1 0 1 1 1 0 Homeobox associated leucine zipper Prominin PF05478.9 001015539.1_06522001_1 - 0.17 9.6 3.0 0.22 9.3 3.0 1.1 1 0 0 1 1 1 0 Prominin DUF4200 PF13863.4 001015539.1_06522001_1 - 0.18 12.1 12.4 0.22 11.8 12.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) DUF3450 PF11932.6 001015539.1_06522001_1 - 0.18 10.9 9.0 0.31 10.2 9.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Herpes_UL6 PF01763.14 001015539.1_06522001_1 - 0.19 10.1 5.6 0.24 9.8 5.6 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like DUF2408 PF10303.7 001015539.1_06522001_1 - 0.22 12.0 7.1 0.28 11.6 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) HAUS4 PF14735.4 001015539.1_06522001_1 - 0.29 10.7 9.1 0.39 10.3 9.1 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 ZYG-11_interact PF05884.10 001015539.1_06522001_1 - 0.35 10.1 1.3 0.44 9.8 1.3 1.1 1 0 0 1 1 1 0 Interactor of ZYG-11 DUF342 PF03961.11 001015539.1_06522001_1 - 0.46 8.9 5.1 0.61 8.5 5.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Baculo_PEP_C PF04513.10 001015539.1_06522001_1 - 0.53 10.2 4.1 0.59 10.0 3.5 1.3 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Seryl_tRNA_N PF02403.20 001015539.1_06522001_1 - 0.58 10.3 10.2 1.1 9.4 9.8 1.5 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Exonuc_VII_L PF02601.13 001015539.1_06522001_1 - 0.61 9.5 5.1 0.8 9.1 5.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1043 PF06295.10 001015539.1_06522001_1 - 0.62 9.9 9.4 0.28 11.1 6.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) TMCO5 PF14992.4 001015539.1_06522001_1 - 0.71 9.3 11.0 0.86 9.0 11.0 1.1 1 0 0 1 1 1 0 TMCO5 family TMPIT PF07851.11 001015539.1_06522001_1 - 0.75 8.8 6.2 1 8.4 6.2 1.1 1 0 0 1 1 1 0 TMPIT-like protein Rootletin PF15035.4 001015539.1_06522001_1 - 1.1 9.2 14.3 2.2 8.2 14.3 1.4 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion GrpE PF01025.17 001015539.1_06522001_1 - 1.3 8.6 9.2 1 8.8 7.9 1.4 1 1 0 1 1 1 0 GrpE CREPT PF16566.3 001015539.1_06522001_1 - 1.5 8.9 10.2 1.7 8.7 8.7 1.7 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour IncA PF04156.12 001015539.1_06522001_1 - 2 8.1 17.0 4.4 6.9 17.0 1.5 1 1 0 1 1 1 0 IncA protein Mnd1 PF03962.13 001015539.1_06522001_1 - 2.7 7.7 10.9 4 7.1 10.9 1.3 1 0 0 1 1 1 0 Mnd1 family OmpH PF03938.12 001015539.1_06522001_1 - 7 6.5 12.1 10 5.9 12.1 1.3 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) HAUS6_N PF14661.4 001015539.1_06522001_1 - 7.2 6.0 11.6 1.6 8.2 7.1 1.8 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Spc24 PF08286.9 001015539.1_06522001_1 - 8 6.6 9.0 20 5.4 8.6 1.8 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 Ribosomal_S4e PF00900.18 001035445.2_06522001_3 - 9.6e-40 134.2 0.5 9.6e-40 134.2 0.5 2.5 3 0 0 3 3 3 1 Ribosomal family S4e 40S_S4_C PF16121.3 001035445.2_06522001_3 - 2.1e-30 104.0 0.1 2.1e-30 104.0 0.1 1.9 2 0 0 2 2 2 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.10 001035445.2_06522001_3 - 3e-22 78.3 6.2 9.1e-22 76.8 6.2 1.9 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.23 001035445.2_06522001_3 - 5.6e-06 25.8 0.0 1e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 S4 domain KOW PF00467.27 001035445.2_06522001_3 - 8.1e-06 25.5 0.2 2.7e-05 23.8 0.2 2.0 1 0 0 1 1 1 1 KOW motif WND PF07861.9 001035445.2_06522001_3 - 0.12 11.6 0.8 0.21 10.8 0.8 1.3 1 0 0 1 1 1 0 WisP family N-Terminal Region Zona_pellucida PF00100.21 001083733.1_06526001_2 - 1.9e-17 63.8 1.3 2.8e-17 63.2 1.3 1.3 1 0 0 1 1 1 1 Zona pellucida-like domain PARG_cat PF05028.12 174138.3_06529001_3 - 2e-133 444.8 0.0 3e-133 444.2 0.0 1.3 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) EBP50_C PF09007.9 001077065.2_06524001_3 - 4.8e-29 101.8 3.7 9.9e-18 65.3 0.7 2.3 1 1 1 2 2 2 2 EBP50, C-terminal PDZ PF00595.22 001077065.2_06524001_3 - 1.8e-15 56.9 0.0 2.6e-15 56.4 0.0 1.2 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001077065.2_06524001_3 - 3.7e-06 27.0 0.0 6.5e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Cor1 PF04803.10 001040588.2_06523001_1 - 8.5e-59 197.4 32.2 1.4e-58 196.7 32.2 1.4 1 0 0 1 1 1 1 Cor1/Xlr/Xmr conserved region Peptidase_C65 PF10275.7 001040588.2_06523001_1 - 0.0091 15.3 7.4 0.014 14.7 7.4 1.3 1 0 0 1 1 1 1 Peptidase C65 Otubain Exonuc_VII_L PF02601.13 001040588.2_06523001_1 - 5.8 6.3 14.7 8.5 5.7 14.7 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Nucleoporin_FG2 PF15967.3 001040588.2_06523001_1 - 5.9 5.2 7.3 7.3 4.9 7.3 1.1 1 0 0 1 1 1 0 Nucleoporin FG repeated region Gastrin PF00918.15 001046603.2_06522001_2 - 4.2e-38 131.0 0.0 6.5e-38 130.4 0.0 1.3 1 0 0 1 1 1 1 Gastrin/cholecystokinin family Metal_resist PF13801.4 001046603.2_06522001_2 - 0.024 14.7 5.1 0.035 14.1 5.1 1.2 1 0 0 1 1 1 0 Heavy-metal resistance Ald_Xan_dh_C2 PF02738.16 176668.3_06529001_1 - 3.9e-186 619.6 0.0 5.1e-186 619.2 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 176668.3_06529001_1 - 9.5e-47 158.8 0.0 2.2e-46 157.6 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.20 176668.3_06529001_1 - 5.5e-36 123.1 0.1 1.4e-35 121.9 0.1 1.7 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.18 176668.3_06529001_1 - 1.3e-29 101.8 1.0 1.3e-29 101.8 1.0 1.9 2 0 0 2 2 2 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.15 176668.3_06529001_1 - 2.7e-29 101.2 0.0 7e-29 99.9 0.0 1.8 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.25 176668.3_06529001_1 - 1.7e-09 37.4 0.1 1.7e-09 37.4 0.1 2.7 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain MAGUK_N_PEST PF10608.7 176668.3_06529001_1 - 0.032 14.6 0.0 0.075 13.4 0.0 1.6 1 0 0 1 1 1 0 Polyubiquitination (PEST) N-terminal domain of MAGUK MHC_I PF00129.16 001168604.1_06523001_1 - 6.2e-15 55.1 1.0 8.1e-15 54.7 1.0 1.1 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 MHC_I_2 PF14586.4 001168604.1_06523001_1 - 3.2e-07 30.2 0.2 4.5e-07 29.8 0.2 1.1 1 0 0 1 1 1 1 Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2 MHC_II_beta PF00969.17 001168604.1_06523001_1 - 0.082 12.9 0.5 0.38 10.8 0.3 2.2 2 0 0 2 2 2 0 Class II histocompatibility antigen, beta domain RNA_pol_Rpc4 PF05132.12 001105654.2_06523001_1 - 0.11 12.8 19.9 0.19 12.0 19.9 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 TMEM234 PF10639.7 001105654.2_06523001_2 - 6.1e-42 142.2 0.5 6.1e-42 142.2 0.5 1.8 2 0 0 2 2 2 1 Putative transmembrane family 234 EamA PF00892.18 001105654.2_06523001_2 - 0.0016 18.5 3.5 0.022 14.8 2.3 2.1 2 0 0 2 2 2 1 EamA-like transporter family RNA_pol_Rpc4 PF05132.12 001105654.2_06523001_2 - 0.0024 18.2 15.4 0.0033 17.7 15.4 1.2 1 0 0 1 1 1 1 RNA polymerase III RPC4 EOS1 PF12326.6 001105654.2_06523001_2 - 10 5.9 12.2 16 5.3 12.2 1.4 1 0 0 1 1 1 0 N-glycosylation protein DUF913 PF06025.10 001105654.2_06523001_2 - 10 4.9 11.6 14 4.4 11.6 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RNA_pol_Rpc4 PF05132.12 001105654.2_06523001_3 - 0.15 12.4 21.1 0.21 11.9 21.1 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 DDHD PF02862.15 001105654.2_06523001_3 - 3.4 7.6 15.3 4.5 7.2 15.3 1.1 1 0 0 1 1 1 0 DDHD domain MHC_I PF00129.16 001082505.1_21023001_1 - 2.3e-95 317.1 0.8 3.4e-95 316.5 0.8 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001082505.1_21023001_1 - 9.1e-17 61.2 0.0 1.8e-16 60.2 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001082505.1_21023001_1 - 1.1e-11 44.3 1.8 2.2e-11 43.4 1.8 1.5 1 0 0 1 1 1 1 MHC_I C-terminus C2-set_2 PF08205.10 001082505.1_21023001_1 - 7.4e-05 22.6 0.1 0.00016 21.5 0.1 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 001082505.1_21023001_1 - 0.00012 22.5 0.5 0.09 13.3 0.0 2.7 1 1 1 2 2 2 2 Immunoglobulin domain ig PF00047.23 001082505.1_21023001_1 - 0.0075 16.3 0.2 0.025 14.6 0.1 1.9 2 0 0 2 2 2 1 Immunoglobulin domain PepSY_TM PF03929.14 001082505.1_21023001_1 - 0.019 14.2 2.4 1.9 7.7 2.7 2.1 1 1 0 1 1 1 0 PepSY-associated TM region Ig_2 PF13895.4 001082505.1_21023001_1 - 0.02 15.1 0.0 0.048 13.9 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain DUF2029 PF09594.8 001082505.1_21023001_1 - 0.071 12.7 0.2 0.24 10.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2029) DUF1049 PF06305.9 001082505.1_21023001_1 - 0.14 11.8 0.1 0.27 11.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) bZIP_2 PF07716.13 001082505.1_21023001_3 - 0.12 12.3 2.7 0.23 11.4 2.7 1.3 1 0 0 1 1 1 0 Basic region leucine zipper NAC PF01849.16 001025314.2_06522001_2 - 2.5e-26 91.3 0.2 4.5e-26 90.5 0.2 1.5 1 0 0 1 1 1 1 NAC domain BK_channel_a PF03493.16 174680.2_06529001_2 - 1.3e-32 111.8 0.2 2.9e-32 110.7 0.2 1.7 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Ion_trans PF00520.29 174680.2_06529001_2 - 3.4e-17 62.4 20.1 3.4e-17 62.4 20.1 2.2 3 0 0 3 3 3 1 Ion transport protein Ion_trans_2 PF07885.14 174680.2_06529001_2 - 1.4e-13 50.5 4.1 1.4e-13 50.5 4.1 2.8 2 0 0 2 2 2 1 Ion channel TrkA_N PF02254.16 174680.2_06529001_2 - 6.3e-05 23.1 0.0 0.0003 20.9 0.0 2.0 2 0 0 2 2 2 1 TrkA-N domain Lig_chan PF00060.24 174680.2_06529001_2 - 0.88 9.3 5.4 1.1 8.9 1.1 2.7 2 0 0 2 2 2 0 Ligand-gated ion channel PRELI PF04707.12 001101975.2_06526001_2 - 2e-52 177.1 0.1 2.9e-52 176.5 0.1 1.2 1 0 0 1 1 1 1 PRELI-like family CRAL_TRIO PF00650.18 001101975.2_06526001_2 - 1.2e-39 135.5 0.0 2e-39 134.7 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.13 001101975.2_06526001_2 - 1.1e-05 25.3 0.1 2.5e-05 24.2 0.1 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain wnt PF00110.17 001082456.2_06525001_1 - 1.9e-104 349.4 13.5 2.5e-104 349.0 13.5 1.1 1 0 0 1 1 1 1 wnt family Lectin_C PF00059.19 001101276.1_06523001_1 - 7e-14 52.3 4.3 7e-14 52.3 4.3 1.9 2 0 0 2 2 2 1 Lectin C-type domain ECSCR PF15820.3 001101276.1_06523001_1 - 0.024 14.3 0.7 0.051 13.3 0.7 1.5 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator EphA2_TM PF14575.4 001101276.1_06523001_1 - 0.67 10.7 0.0 0.67 10.7 0.0 2.7 3 1 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain OAD_gamma PF04277.11 001101276.1_06523001_1 - 1.8 9.0 4.9 13 6.4 0.9 2.4 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain TK PF00265.16 001097572.1_06524001_2 - 1.2e-69 233.6 0.4 1.6e-69 233.2 0.4 1.2 1 0 0 1 1 1 1 Thymidine kinase AAA_14 PF13173.4 001097572.1_06524001_2 - 0.0057 16.6 0.0 0.0084 16.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain BACK PF07707.13 001077125.2_06523001_2 - 7.1e-34 115.9 0.1 1.4e-33 114.9 0.1 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.29 001077125.2_06523001_2 - 6.9e-32 109.8 1.3 9.6e-32 109.4 0.6 1.6 2 0 0 2 2 2 1 BTB/POZ domain TLE_N PF03920.13 001081583.1_06526001_3 - 2.6e-74 247.4 12.0 3.7e-74 246.9 12.0 1.2 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain WD40 PF00400.30 001081583.1_06526001_3 - 7.5e-17 61.3 18.0 0.019 15.7 0.8 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001081583.1_06526001_3 - 9.3e-08 32.1 0.0 0.18 12.0 0.0 4.4 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 001081583.1_06526001_3 - 0.027 13.7 0.0 9.2 5.4 0.2 2.5 2 1 0 2 2 2 0 WD40-like domain Cytochrom_D1 PF02239.14 001081583.1_06526001_3 - 0.07 11.5 0.0 2.1 6.6 0.0 2.2 2 0 0 2 2 2 0 Cytochrome D1 heme domain Ric8 PF10165.7 001015627.2_06525001_2 - 5.2e-125 417.9 0.2 8.5e-125 417.2 0.2 1.3 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn PUL PF08324.9 001015627.2_06525001_2 - 0.097 11.8 0.3 0.17 11.0 0.3 1.4 1 1 0 1 1 1 0 PUL domain Arm PF00514.21 001015627.2_06525001_2 - 0.38 10.7 2.0 1.4 8.9 0.0 3.1 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Cullin_binding PF03556.13 001102233.2_06522001_2 - 6.2e-37 126.5 2.6 1.1e-36 125.7 0.8 2.0 2 0 0 2 2 2 1 Cullin binding UBA_4 PF14555.4 001102233.2_06522001_2 - 5.7e-10 38.7 0.1 5.7e-10 38.7 0.1 2.4 3 0 0 3 3 3 1 UBA-like domain TAP_C PF03943.11 001102233.2_06522001_2 - 0.011 15.1 0.1 0.082 12.4 0.2 2.5 2 0 0 2 2 2 0 TAP C-terminal domain RRM_1 PF00076.20 001037485.2_06521001_2 - 2e-13 49.8 0.0 2.9e-13 49.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 001037485.2_06521001_2 - 0.011 15.6 0.0 0.016 15.1 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.11 001037485.2_06521001_2 - 0.034 14.0 0.0 0.061 13.2 0.0 1.4 1 1 0 1 1 1 0 Nup53/35/40-type RNA recognition motif V_ATPase_I PF01496.17 001038133.1_06523001_1 - 0.0052 14.6 4.0 0.0061 14.4 4.0 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF1510 PF07423.9 001038133.1_06523001_1 - 0.029 13.7 12.5 0.039 13.3 12.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) FAM176 PF14851.4 001038133.1_06523001_1 - 0.27 10.8 2.2 0.41 10.2 2.2 1.2 1 0 0 1 1 1 0 FAM176 family CLN3 PF02487.15 001038133.1_06523001_1 - 0.52 9.2 3.8 0.68 8.8 3.8 1.1 1 0 0 1 1 1 0 CLN3 protein Presenilin PF01080.15 001038133.1_06523001_1 - 3.3 6.2 7.8 4.6 5.7 7.8 1.2 1 0 0 1 1 1 0 Presenilin CN_hydrolase PF00795.20 001038133.1_06523001_3 - 2.7e-65 220.2 0.0 3.2e-65 219.9 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase RNA_pol_Rpc4 PF05132.12 001038133.1_06523001_3 - 0.024 14.9 9.6 0.036 14.4 9.6 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 EOS1 PF12326.6 001038133.1_06523001_3 - 0.091 12.6 1.9 0.11 12.3 1.9 1.2 1 0 0 1 1 1 0 N-glycosylation protein DUF3807 PF12720.5 001038133.1_06523001_3 - 3.3 7.8 22.1 5 7.3 22.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) CBAH PF02275.16 001075459.2_06524001_3 - 1.5e-51 175.8 0.9 1.1e-50 173.0 0.9 1.9 1 1 0 1 1 1 1 Linear amide C-N hydrolases, choloylglycine hydrolase family NAAA-beta PF15508.4 001075459.2_06524001_3 - 5.8e-21 74.4 0.3 2.4e-20 72.5 0.2 2.1 2 0 0 2 2 2 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase RPA_C PF08784.9 001045984.2_06524001_3 - 1.2e-24 86.8 0.1 2.9e-24 85.6 0.0 1.7 2 0 0 2 2 2 1 Replication protein A C terminal tRNA_anti-codon PF01336.23 001045984.2_06524001_3 - 8.7e-06 25.5 0.0 1.5e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Lectin_C PF00059.19 205787.1_06522001_2 - 3.4e-19 69.4 0.1 4.9e-19 68.9 0.1 1.2 1 0 0 1 1 1 1 Lectin C-type domain E1-E2_ATPase PF00122.18 175785.2_06527001_2 - 4.5e-61 205.8 0.8 1.2e-60 204.4 0.8 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 175785.2_06527001_2 - 7.6e-46 156.0 4.0 7.6e-46 156.0 4.0 2.2 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.24 175785.2_06527001_2 - 4.2e-22 79.3 2.4 2.7e-21 76.7 2.4 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 175785.2_06527001_2 - 4.6e-18 64.5 0.0 1e-17 63.4 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.4 175785.2_06527001_2 - 4.2e-17 61.9 0.0 2.6e-15 56.2 0.0 2.6 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.10 175785.2_06527001_2 - 0.00021 21.0 2.7 0.0005 19.7 2.7 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase KxDL PF10241.7 001034605.2_06523001_2 - 3.1e-30 104.1 1.9 5.4e-30 103.4 1.9 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein TolA_bind_tri PF16331.3 001034605.2_06523001_2 - 0.074 13.0 0.3 0.14 12.1 0.3 1.4 1 0 0 1 1 1 0 TolA binding protein trimerisation Med4 PF10018.7 001034486.1_06523001_3 - 2.7e-31 108.7 0.3 4.1e-31 108.0 0.3 1.2 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 Mu-like_Pro PF10123.7 001034486.1_06523001_3 - 0.00045 19.7 1.0 0.00064 19.2 1.0 1.2 1 0 0 1 1 1 1 Mu-like prophage I protein HMMR_N PF15905.3 001034486.1_06523001_3 - 0.0009 18.7 9.5 0.0013 18.2 9.5 1.2 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal ALIX_LYPXL_bnd PF13949.4 001034486.1_06523001_3 - 0.022 13.9 6.5 0.034 13.3 6.5 1.2 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV DUF4094 PF13334.4 001034486.1_06523001_3 - 0.13 12.5 1.4 0.26 11.6 1.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) Phage_GPO PF05929.9 001034486.1_06523001_3 - 0.53 9.8 4.4 0.76 9.2 4.4 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Aldo_ket_red PF00248.19 181027.2_06523001_3 - 2e-59 201.0 0.0 2.4e-59 200.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Pkinase PF00069.23 001101205.1_06526001_2 - 1.7e-60 204.5 0.0 2.2e-60 204.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001101205.1_06526001_2 - 1.7e-24 86.4 0.0 2.3e-24 86.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase NGF PF00243.16 001081787.1_21022001_1 - 2.4e-48 162.9 2.3 3.2e-48 162.5 2.3 1.2 1 0 0 1 1 1 1 Nerve growth factor family Spaetzle PF16077.3 001081787.1_21022001_1 - 0.00032 21.0 0.6 0.00047 20.4 0.6 1.2 1 0 0 1 1 1 1 Spaetzle SAA PF00277.16 001081853.1_21021001_1 - 8.5e-50 167.4 3.5 1e-49 167.1 3.5 1.1 1 0 0 1 1 1 1 Serum amyloid A protein TNFR_c6 PF00020.16 001098056.2_06525001_1 - 7.5e-28 96.5 32.1 1.6e-09 37.9 10.7 4.5 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region Death PF00531.20 001098056.2_06525001_1 - 3.8e-13 49.3 5.5 1.2e-07 31.7 0.3 2.3 1 1 1 2 2 2 2 Death domain Ephrin_rec_like PF07699.11 001098056.2_06525001_1 - 2.5 7.8 26.2 0.72 9.5 0.6 4.0 1 1 2 3 3 3 0 Putative ephrin-receptor like Sld5 PF05916.9 001076136.1_06525001_2 - 2.5e-08 34.2 0.0 4.5e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 GINS complex protein Ly49 PF08391.8 001082529.1_21023001_2 - 5.8e-51 171.7 2.8 9.2e-51 171.1 2.8 1.3 1 0 0 1 1 1 1 Ly49-like protein, N-terminal region Lectin_C PF00059.19 001082529.1_21023001_2 - 1e-10 42.2 0.1 1.9e-10 41.3 0.1 1.4 1 0 0 1 1 1 1 Lectin C-type domain Stig1 PF04885.11 001082529.1_21023001_2 - 0.02 15.2 2.5 0.03 14.7 2.5 1.2 1 0 0 1 1 1 0 Stigma-specific protein, Stig1 Ribosomal_L22e PF01776.15 001098131.1_06523001_1 - 1.3e-46 157.3 5.3 1.8e-46 156.8 5.3 1.2 1 0 0 1 1 1 1 Ribosomal L22e protein family Ufd2P_core PF10408.7 001098999.1_06527001_1 - 1.8e-155 518.9 9.1 2.5e-155 518.4 9.1 1.2 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.13 001098999.1_06527001_1 - 2.7e-32 110.6 0.5 9.2e-32 108.9 0.5 2.0 1 0 0 1 1 1 1 U-box domain STAT_bind PF02864.13 174617.4_06526001_1 - 6.2e-103 343.9 6.8 8.1e-103 343.5 1.7 2.3 2 0 0 2 2 2 1 STAT protein, DNA binding domain STAT_alpha PF01017.18 174617.4_06526001_1 - 4.4e-54 182.9 23.0 9.5e-54 181.8 23.0 1.6 1 0 0 1 1 1 1 STAT protein, all-alpha domain STAT_int PF02865.15 174617.4_06526001_1 - 3.4e-45 153.3 2.1 3.4e-45 153.3 2.1 3.1 3 1 0 3 3 3 1 STAT protein, protein interaction domain SH2 PF00017.22 174617.4_06526001_1 - 8.1e-12 44.9 0.1 1.8e-10 40.6 0.0 3.0 3 0 0 3 3 3 1 SH2 domain 7tm_2 PF00002.22 176661.1_06525001_1 - 4.5e-67 225.8 16.1 7e-67 225.2 16.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) EGF_CA PF07645.13 176661.1_06525001_1 - 1.6e-21 76.1 39.7 6.1e-14 51.8 8.5 4.4 4 0 0 4 4 4 2 Calcium-binding EGF domain GPS PF01825.19 176661.1_06525001_1 - 2.1e-12 47.3 5.0 2.1e-12 47.3 5.0 3.3 4 0 0 4 4 1 1 GPCR proteolysis site, GPS, motif EGF_3 PF12947.5 176661.1_06525001_1 - 8e-08 32.2 31.4 3e-05 24.0 1.8 4.6 4 0 0 4 4 4 2 EGF domain cEGF PF12662.5 176661.1_06525001_1 - 8.8e-08 31.8 23.0 1.6e-05 24.5 1.6 4.5 4 0 0 4 4 4 3 Complement Clr-like EGF-like hEGF PF12661.5 176661.1_06525001_1 - 1.5e-05 25.3 48.0 0.0001 22.7 6.3 5.2 5 0 0 5 5 5 3 Human growth factor-like EGF EGF_MSP1_1 PF12946.5 176661.1_06525001_1 - 0.00052 19.9 25.6 0.74 9.8 2.8 5.3 4 0 0 4 4 4 3 MSP1 EGF domain 1 EGF PF00008.25 176661.1_06525001_1 - 0.00055 20.0 8.0 0.00055 20.0 8.0 4.9 5 0 0 5 5 4 2 EGF-like domain GAIN PF16489.3 176661.1_06525001_1 - 0.0043 16.4 1.0 0.0073 15.6 1.0 1.3 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Dicty_CAR PF05462.9 176661.1_06525001_1 - 0.02 13.9 13.6 0.036 13.1 13.6 1.3 1 0 0 1 1 1 0 Slime mold cyclic AMP receptor FXa_inhibition PF14670.4 176661.1_06525001_1 - 0.18 12.0 37.0 0.033 14.4 7.2 4.4 4 0 0 4 4 4 0 Coagulation Factor Xa inhibitory site DUF872 PF05915.10 176661.1_06525001_1 - 0.62 10.2 2.7 1.4 9.1 0.3 2.6 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) Arf PF00025.19 001083671.1_06523001_1 - 1.5e-75 252.3 0.1 2.2e-75 251.8 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 001083671.1_06523001_1 - 1.4e-13 51.0 0.1 1.4e-13 51.0 0.1 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 001083671.1_06523001_1 - 2.8e-13 49.6 0.0 2.8e-13 49.6 0.0 1.8 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Ras PF00071.20 001083671.1_06523001_1 - 5.6e-12 45.4 0.0 7.8e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.10 001083671.1_06523001_1 - 2.4e-10 40.0 0.0 2.4e-10 40.0 0.0 1.8 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region G-alpha PF00503.18 001083671.1_06523001_1 - 3.5e-09 36.1 1.1 3e-08 33.1 0.1 2.8 2 1 1 3 3 3 2 G-protein alpha subunit RNA_pol_Rpc4 PF05132.12 001083671.1_06523001_1 - 0.0021 18.4 4.4 0.0032 17.8 4.4 1.3 1 0 0 1 1 1 1 RNA polymerase III RPC4 AAA_23 PF13476.4 001083671.1_06523001_1 - 0.013 15.9 7.6 0.013 15.9 7.6 2.4 2 1 0 2 2 2 0 AAA domain EOS1 PF12326.6 001083671.1_06523001_1 - 0.064 13.1 0.0 0.064 13.1 0.0 1.2 1 0 0 1 1 1 0 N-glycosylation protein EOS1 PF12326.6 001083671.1_06523001_3 - 0.044 13.6 0.1 0.049 13.4 0.1 1.2 1 0 0 1 1 1 0 N-glycosylation protein FHIPEP PF00771.18 001083671.1_06523001_3 - 7.8 4.7 4.8 10 4.3 4.8 1.0 1 0 0 1 1 1 0 FHIPEP family DEAD PF00270.27 001034228.1_06524001_1 - 3.6e-44 150.5 0.3 5.8e-44 149.8 0.3 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001034228.1_06524001_1 - 4.1e-31 107.5 0.7 2e-30 105.3 0.1 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.13 001034228.1_06524001_1 - 7.8e-07 29.1 0.0 1.3e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.4 001034228.1_06524001_1 - 0.00082 19.6 0.4 0.0023 18.2 0.1 1.9 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.4 001034228.1_06524001_1 - 0.0042 16.7 0.0 0.007 16.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.12 001034228.1_06524001_1 - 0.077 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Helicase Flavi_DEAD PF07652.12 001034228.1_06524001_1 - 0.088 12.6 0.0 0.53 10.1 0.0 2.1 2 0 0 2 2 2 0 Flavivirus DEAD domain SBF PF01758.14 001078025.1_06525001_1 - 1.1e-33 116.4 14.8 2.1e-33 115.5 14.8 1.4 1 0 0 1 1 1 1 Sodium Bile acid symporter family Dus PF01207.15 001075419.1_06524001_1 - 2.4e-52 177.8 0.1 4.2e-52 177.0 0.1 1.4 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) dsrm PF00035.24 001075419.1_06524001_1 - 5.4e-06 26.9 0.0 1.4e-05 25.5 0.0 1.7 1 0 0 1 1 1 1 Double-stranded RNA binding motif TMP-TENI PF02581.15 001075419.1_06524001_1 - 0.14 11.4 0.0 0.49 9.6 0.0 1.9 2 0 0 2 2 2 0 Thiamine monophosphate synthase/TENI His_biosynth PF00977.19 001075419.1_06524001_1 - 0.15 11.4 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein PucR PF07905.9 001075419.1_06524001_1 - 0.16 12.1 0.0 1.1 9.4 0.0 2.1 2 0 0 2 2 2 0 Purine catabolism regulatory protein-like family FBPase PF00316.18 001034447.2_06523001_3 - 2.5e-80 268.4 0.3 3.3e-80 268.0 0.3 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.23 001034447.2_06523001_3 - 0.00027 20.4 0.0 0.0005 19.5 0.0 1.4 1 0 0 1 1 1 1 Inositol monophosphatase family Ank_5 PF13857.4 001034447.2_06523001_3 - 0.088 13.1 0.0 0.21 11.9 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) ABC2_membrane PF01061.22 001034447.2_06523001_3 - 0.11 11.8 0.0 0.75 9.0 0.0 2.0 2 0 0 2 2 2 0 ABC-2 type transporter Cir_N PF10197.7 001105359.1_06524001_1 - 2.2e-15 56.4 13.4 2.2e-15 56.4 13.4 3.2 2 1 0 2 2 2 1 N-terminal domain of CBF1 interacting co-repressor CIR CWC25 PF12542.6 001105359.1_06524001_1 - 6.4e-15 55.6 0.0 6.4e-15 55.6 0.0 2.9 3 0 0 3 3 3 1 Pre-mRNA splicing factor DUF4604 PF15377.4 001105359.1_06524001_1 - 0.015 15.6 13.6 0.015 15.6 13.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) EphA2_TM PF14575.4 001105359.1_06524001_1 - 1.7 9.4 3.7 3.8 8.2 3.7 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain RVT_1 PF00078.25 001105359.1_06524001_2 - 1.5e-09 37.6 0.0 2.6e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4061 PF13270.4 001034305.2_06522001_1 - 1.5e-08 34.7 0.2 2.5e-08 34.1 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4061) DUF4061 PF13270.4 001034305.2_06522001_3 - 4.2e-09 36.5 0.0 6.9e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4061) Aldo_ket_red PF00248.19 001081895.2_21023001_2 - 1.3e-55 188.5 0.0 1.6e-55 188.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family WBS_methylT PF12589.6 001034457.2_06523001_1 - 1.6e-16 60.6 0.6 1.6e-16 60.6 0.6 2.8 2 1 0 2 2 2 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.10 001034457.2_06523001_1 - 2.3e-12 47.3 0.0 3.9e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 001034457.2_06523001_1 - 4.3e-12 46.5 0.0 7.3e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.4 001034457.2_06523001_1 - 3.4e-06 26.8 0.0 5.7e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001034457.2_06523001_1 - 3.5e-05 24.3 0.0 3.5e-05 24.3 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.4 001034457.2_06523001_1 - 0.00034 20.4 0.0 0.00053 19.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Presenilin PF01080.15 001034457.2_06523001_1 - 0.055 12.1 1.6 0.063 11.9 1.6 1.2 1 0 0 1 1 1 0 Presenilin MetW PF07021.10 001034457.2_06523001_1 - 0.075 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Presenilin PF01080.15 001034457.2_06523001_2 - 0.66 8.5 7.2 1 7.9 7.2 1.4 1 0 0 1 1 1 0 Presenilin EOS1 PF12326.6 001034457.2_06523001_2 - 1.2 8.9 6.3 1.8 8.3 6.3 1.4 1 0 0 1 1 1 0 N-glycosylation protein DUF4228 PF14009.4 001034457.2_06523001_3 - 0.016 15.6 7.4 0.022 15.1 7.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) DDHD PF02862.15 001034457.2_06523001_3 - 1.2 9.0 9.4 1.6 8.7 9.4 1.1 1 0 0 1 1 1 0 DDHD domain DUF3807 PF12720.5 001034457.2_06523001_3 - 2.6 8.2 20.8 3.3 7.9 20.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Connexin PF00029.17 001034457.2_06523001_3 - 2.7 7.6 16.3 3.8 7.1 16.3 1.2 1 0 0 1 1 1 0 Connexin NARP1 PF12569.6 001034457.2_06523001_3 - 3.7 6.2 27.4 4.4 5.9 27.4 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 EOS1 PF12326.6 001034457.2_06523001_3 - 4.6 7.0 6.9 5.9 6.6 6.9 1.2 1 0 0 1 1 1 0 N-glycosylation protein Presenilin PF01080.15 001034457.2_06523001_3 - 7.4 5.1 9.0 9.1 4.8 9.0 1.1 1 0 0 1 1 1 0 Presenilin Ribosomal_S11 PF00411.17 001077830.2_06522001_3 - 4e-37 126.8 0.6 6.9e-37 126.1 0.4 1.4 1 1 0 1 1 1 1 Ribosomal protein S11 CBM_25 PF03423.11 001077830.2_06522001_3 - 0.13 12.3 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) Actin PF00022.17 001038570.1_06524001_3 - 1e-101 340.4 0.0 2.6e-100 335.8 0.0 2.0 1 1 0 1 1 1 1 Actin ACTL7A_N PF16840.3 001038570.1_06524001_3 - 9.6e-32 108.7 2.4 2.2e-31 107.6 2.4 1.6 1 0 0 1 1 1 1 Actin-like protein 7A N-terminus MreB_Mbl PF06723.11 001038570.1_06524001_3 - 0.00019 20.3 0.0 0.44 9.2 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Cauli_AT PF03233.11 001038570.1_06524001_3 - 0.18 11.6 0.0 0.27 11.0 0.0 1.2 1 0 0 1 1 1 0 Aphid transmission protein GSH_synth_ATP PF03917.15 001015630.1_06524001_2 - 2.1e-128 428.1 0.0 2.7e-128 427.8 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.13 001015630.1_06524001_2 - 3.8e-33 113.9 0.0 6.6e-33 113.1 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Pkinase PF00069.23 178109.3_06525001_2 - 8.5e-57 192.4 0.1 1.7e-56 191.4 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 178109.3_06525001_2 - 8.5e-35 120.1 0.0 1.3e-34 119.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase dsrm PF00035.24 178109.3_06525001_2 - 3e-28 98.2 6.4 2.3e-15 56.9 0.3 3.4 3 0 0 3 3 3 2 Double-stranded RNA binding motif Kdo PF06293.12 178109.3_06525001_2 - 0.0082 15.4 0.0 0.014 14.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.14 178109.3_06525001_2 - 0.0087 16.1 0.0 0.02 14.9 0.0 1.5 1 0 0 1 1 1 1 ABC1 family DND1_DSRM PF14709.5 178109.3_06525001_2 - 0.072 13.2 3.6 0.22 11.7 0.1 3.1 2 2 0 2 2 2 0 double strand RNA binding domain from DEAD END PROTEIN 1 EF-hand_7 PF13499.4 001103245.1_06525001_1 - 2.4e-07 31.0 1.7 4.6e-07 30.1 1.7 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 001103245.1_06525001_1 - 8.4e-07 28.0 10.1 9.3e-05 21.6 2.7 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 001103245.1_06525001_1 - 2.7e-06 26.7 1.8 0.00022 20.8 0.2 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.4 001103245.1_06525001_1 - 0.02 14.3 0.3 0.02 14.3 0.3 2.4 3 0 0 3 3 3 0 EF hand SPARC_Ca_bdg PF10591.7 001103245.1_06525001_1 - 0.069 13.3 0.0 0.069 13.3 0.0 1.8 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.4 001103245.1_06525001_1 - 0.98 9.1 6.2 4 7.1 1.0 2.3 2 0 0 2 2 2 0 EF-hand domain pair YTH PF04146.13 001046520.1_06527001_3 - 1.6e-39 134.2 0.0 2.6e-39 133.5 0.0 1.4 1 0 0 1 1 1 1 YT521-B-like domain Hydrolase_6 PF13344.4 001035035.2_06524001_3 - 5.8e-25 87.2 0.0 9e-25 86.6 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.4 001035035.2_06524001_3 - 3.1e-19 68.7 0.0 5.5e-19 67.9 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.24 001035035.2_06524001_3 - 3e-10 40.6 0.0 4.8e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.4 001035035.2_06524001_3 - 1.1e-05 25.4 0.0 0.00011 22.2 0.0 2.0 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.8 001035035.2_06524001_3 - 0.00082 18.9 0.0 0.0014 18.1 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase CUB PF00431.18 001081906.1_21022001_2 - 4.9e-36 123.3 0.1 8e-36 122.6 0.1 1.4 1 0 0 1 1 1 1 CUB domain Xlink PF00193.15 001081906.1_21022001_2 - 3.8e-30 104.0 0.1 5.9e-30 103.4 0.1 1.3 1 0 0 1 1 1 1 Extracellular link domain CP2 PF04516.13 001083397.1_06526001_1 - 3.7e-57 193.1 0.0 6.4e-57 192.4 0.0 1.3 1 0 0 1 1 1 1 CP2 transcription factor 7tm_1 PF00001.19 174497.3_06526001_1 - 6.2e-51 173.1 15.3 7.6e-51 172.8 15.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 174497.3_06526001_1 - 9.4e-11 41.4 13.1 3.1e-10 39.7 13.1 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 174497.3_06526001_1 - 2.7e-08 33.8 10.3 9.1e-08 32.0 10.3 1.7 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 174497.3_06526001_1 - 0.16 11.1 11.1 0.041 13.1 7.8 1.7 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx Glyco_transf_29 PF00777.16 001002883.2_06529001_2 - 2e-58 197.8 0.0 2.8e-58 197.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Glyco_transf_8 PF01501.18 001045867.1_06524001_2 - 3.1e-17 62.9 0.1 4.3e-15 55.8 0.1 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.6 001045867.1_06524001_2 - 0.017 14.3 0.0 0.026 13.7 0.0 1.2 1 0 0 1 1 1 0 Mannosyltransferase putative HS1_rep PF02218.13 001035057.2_06527001_3 - 4.7e-67 222.0 33.8 2.3e-19 69.4 6.8 5.3 5 0 0 5 5 5 4 Repeat in HS1/Cortactin SH3_1 PF00018.26 001035057.2_06527001_3 - 3.3e-16 58.5 0.1 3.3e-16 58.5 0.1 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 001035057.2_06527001_3 - 3.3e-15 55.5 0.2 6.4e-15 54.6 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001035057.2_06527001_3 - 2.6e-08 33.3 0.0 7.1e-08 31.9 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain TMEM210 PF15195.4 001035057.2_06527001_3 - 0.034 14.4 0.1 24 5.3 0.0 3.4 2 1 2 4 4 4 0 TMEM210 family SPESP1 PF15754.3 001035057.2_06527001_3 - 7 5.6 8.1 15 4.5 8.1 1.5 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 PP2C_C PF07830.11 001102128.1_06522001_1 - 1.9e-23 82.5 0.0 2.8e-23 82.0 0.0 1.3 1 0 0 1 1 1 1 Protein serine/threonine phosphatase 2C, C-terminal domain Ldl_recept_b PF00058.15 001097565.1_06529001_1 - 4.3e-58 193.4 2.1 5.6e-13 49.0 0.0 5.4 5 0 0 5 5 5 5 Low-density lipoprotein receptor repeat class B Ldl_recept_a PF00057.16 001097565.1_06529001_1 - 1.1e-37 127.8 90.5 1.8e-11 43.9 11.3 5.1 5 0 0 5 5 5 4 Low-density lipoprotein receptor domain class A FXa_inhibition PF14670.4 001097565.1_06529001_1 - 4.5e-15 55.5 53.9 7.2e-09 35.7 8.2 5.4 5 0 0 5 5 5 3 Coagulation Factor Xa inhibitory site cEGF PF12662.5 001097565.1_06529001_1 - 6.1e-10 38.7 15.1 8.4e-07 28.7 1.5 4.4 3 0 0 3 3 3 2 Complement Clr-like EGF-like SGL PF08450.10 001097565.1_06529001_1 - 3.5e-07 29.9 0.1 0.0061 16.0 0.0 2.5 1 1 1 2 2 2 2 SMP-30/Gluconolaconase/LRE-like region EGF_CA PF07645.13 001097565.1_06529001_1 - 2.2e-06 27.6 9.3 2.2e-06 27.6 9.3 6.8 4 1 2 6 6 6 2 Calcium-binding EGF domain TMEM154 PF15102.4 001097565.1_06529001_1 - 0.0016 18.2 0.3 0.0045 16.8 0.3 1.7 1 1 0 1 1 1 1 TMEM154 protein family DUF4690 PF15756.3 001097565.1_06529001_1 - 0.029 14.8 2.2 0.04 14.4 0.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4690) SKG6 PF08693.8 001097565.1_06529001_1 - 0.064 12.5 0.8 0.13 11.5 0.8 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Homeobox PF00046.27 001102373.1_06524001_1 - 6.3e-22 77.0 8.1 1.4e-21 76.0 8.1 1.6 1 0 0 1 1 1 1 Homeobox domain DUF2209 PF09974.7 001102373.1_06524001_1 - 0.063 13.5 0.1 0.098 12.9 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) fn3 PF00041.19 001034339.1_06524001_3 - 0.00011 22.4 0.1 0.65 10.3 0.0 2.3 2 0 0 2 2 2 2 Fibronectin type III domain Ig_3 PF13927.4 001034339.1_06524001_3 - 0.004 17.6 0.1 0.015 15.8 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain EpoR_lig-bind PF09067.8 001034339.1_06524001_3 - 0.014 15.5 0.0 0.036 14.1 0.0 1.6 2 0 0 2 2 2 0 Erythropoietin receptor, ligand binding Ig_2 PF13895.4 001034339.1_06524001_3 - 0.017 15.3 0.0 0.087 13.1 0.0 2.0 2 0 0 2 2 2 0 Immunoglobulin domain Transferrin PF00405.15 001046279.2_06525001_1 - 2.3e-228 756.6 5.2 1.1e-159 530.8 0.4 2.1 2 0 0 2 2 2 2 Transferrin Phosphonate-bd PF12974.5 001046279.2_06525001_1 - 5.1e-09 35.9 0.0 0.00013 21.5 0.0 2.3 2 0 0 2 2 2 2 ABC transporter, phosphonate, periplasmic substrate-binding protein PSS PF03034.13 001046040.1_06525001_2 - 2.3e-105 352.1 23.0 2.3e-105 352.1 23.0 1.7 2 0 0 2 2 2 1 Phosphatidyl serine synthase Cyt_b-c1_8 PF10890.6 001046040.1_06525001_2 - 0.072 13.4 0.1 0.17 12.1 0.1 1.6 1 0 0 1 1 1 0 Cytochrome b-c1 complex subunit 8 Rcd1 PF04078.11 001101167.2_06527001_3 - 2.5e-135 449.6 0.9 3.1e-135 449.3 0.9 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like p450 PF00067.20 001046391.1_06524001_1 - 3.2e-128 428.3 0.0 3.7e-128 428.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_C65 PF10275.7 001046391.1_06524001_1 - 0.12 11.7 0.2 0.19 11.0 0.2 1.2 1 0 0 1 1 1 0 Peptidase C65 Otubain HMG_box PF00505.17 001081810.1_21023001_1 - 1.3e-25 89.5 1.7 2.4e-25 88.6 1.7 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 001081810.1_21023001_1 - 1.7e-08 34.8 1.7 2.7e-08 34.2 1.7 1.3 1 0 0 1 1 1 1 HMG-box domain polyprenyl_synt PF00348.15 177497.2_06523001_1 - 2.2e-95 318.4 0.0 2.8e-95 318.1 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase DUF148 PF02520.15 177497.2_06523001_1 - 0.16 12.0 1.3 1.1 9.3 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF148 2OG-FeII_Oxy_2 PF13532.4 001075553.2_06523001_2 - 0.00087 19.4 0.0 0.0027 17.8 0.0 1.8 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Methyltr_RsmB-F PF01189.15 001083670.2_06526001_2 - 1e-44 152.5 0.0 1.5e-44 151.9 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.4 001083670.2_06526001_2 - 1.5e-08 34.4 0.0 2.4e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.17 001083670.2_06526001_2 - 1.8e-07 31.3 0.0 3.8e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase PUA PF01472.18 001083670.2_06526001_2 - 0.003 17.4 0.1 0.0057 16.5 0.1 1.4 1 0 0 1 1 1 1 PUA domain PCMT PF01135.17 001083670.2_06526001_2 - 0.0088 15.7 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.4 001083670.2_06526001_2 - 0.08 13.5 0.1 0.38 11.4 0.1 2.1 1 1 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.16 001083670.2_06526001_2 - 0.16 11.2 0.0 0.31 10.2 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family HCO3_cotransp PF00955.19 001038128.1_06529001_1 - 1.9e-248 825.3 6.9 2.4e-248 825.0 6.9 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.11 001038128.1_06529001_1 - 9e-106 353.4 0.0 1.4e-105 352.8 0.0 1.3 1 0 0 1 1 1 1 Band 3 cytoplasmic domain Cyclin_N2 PF16500.3 001075123.1_06524001_1 - 3.7e-50 170.1 1.4 5.7e-50 169.5 1.4 1.3 1 0 0 1 1 1 1 N-terminal region of cyclin_N Cyclin_N PF00134.21 001075123.1_06524001_1 - 2.5e-48 162.9 0.2 4.1e-48 162.2 0.2 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 001075123.1_06524001_1 - 5.4e-28 97.3 0.4 1.4e-27 96.0 0.1 1.8 2 0 0 2 2 2 1 Cyclin, C-terminal domain Rep_fac_C PF08542.9 001045894.1_06523001_2 - 1.9e-17 63.3 0.1 3.5e-17 62.4 0.1 1.4 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.27 001045894.1_06523001_2 - 2.7e-17 63.3 0.0 6.4e-17 62.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.4 001045894.1_06523001_2 - 1.8e-12 47.2 0.0 5.4e-10 39.2 0.0 2.3 2 0 0 2 2 2 1 DNA polymerase III, delta subunit Rad17 PF03215.13 001045894.1_06523001_2 - 6.6e-10 38.4 0.0 1.3e-05 24.2 0.0 2.2 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_assoc_2 PF16193.3 001045894.1_06523001_2 - 6.9e-06 26.1 0.3 2.9e-05 24.1 0.2 2.2 2 1 0 2 2 2 1 AAA C-terminal domain AAA_16 PF13191.4 001045894.1_06523001_2 - 2e-05 24.9 0.1 0.0019 18.5 0.0 2.6 2 1 1 3 3 3 1 AAA ATPase domain DUF815 PF05673.11 001045894.1_06523001_2 - 9.5e-05 21.5 0.0 0.00017 20.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_11 PF13086.4 001045894.1_06523001_2 - 0.00042 20.0 0.1 0.0017 18.0 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.4 001045894.1_06523001_2 - 0.00052 19.7 0.0 0.0011 18.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.4 001045894.1_06523001_2 - 0.00062 19.4 0.0 0.0017 17.9 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.4 001045894.1_06523001_2 - 0.001 19.2 0.1 0.073 13.2 0.0 2.8 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.10 001045894.1_06523001_2 - 0.0026 16.9 0.0 0.0054 15.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus DNA_pol3_delta PF06144.11 001045894.1_06523001_2 - 0.004 16.8 0.1 0.0087 15.7 0.1 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Mg_chelatase PF01078.19 001045894.1_06523001_2 - 0.0089 15.3 0.0 0.11 11.7 0.0 2.3 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.4 001045894.1_06523001_2 - 0.0092 16.2 0.1 0.099 12.8 0.0 2.3 2 1 0 2 2 2 1 AAA domain DEAD PF00270.27 001045894.1_06523001_2 - 0.016 14.9 0.7 1.9 8.1 0.0 3.0 2 1 0 3 3 3 0 DEAD/DEAH box helicase AAA_5 PF07728.12 001045894.1_06523001_2 - 0.05 13.5 0.1 0.43 10.5 0.1 2.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Tmemb_9 PF05434.9 001034507.2_06524001_3 - 5.3e-54 181.9 0.4 7.8e-54 181.4 0.4 1.3 1 0 0 1 1 1 1 TMEM9 B3_4 PF03483.15 001105021.2_06524001_2 - 6e-26 91.0 0.1 1.3e-25 89.9 0.1 1.6 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.13 001105021.2_06524001_2 - 2.1e-16 59.9 0.8 5.9e-14 52.0 0.1 3.3 4 0 0 4 4 4 2 tRNA synthetase B5 domain GLTP PF08718.9 001075182.2_06524001_2 - 1.2e-40 139.1 0.0 1.6e-40 138.7 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) DAP10 PF07213.9 174627.1_06521001_1 - 0.0034 17.2 2.1 0.0046 16.7 2.1 1.2 1 0 0 1 1 1 1 DAP10 membrane protein IncA PF04156.12 174627.1_06521001_1 - 0.055 13.1 0.3 0.083 12.5 0.3 1.3 1 1 0 1 1 1 0 IncA protein wnt PF00110.17 001099363.2_06525001_2 - 7.9e-121 403.1 27.3 9.4e-121 402.9 27.3 1.0 1 0 0 1 1 1 1 wnt family Pkinase PF00069.23 001102174.1_06529001_3 - 3.9e-64 216.4 0.0 4.9e-64 216.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001102174.1_06529001_3 - 8.2e-30 103.8 0.0 1.2e-29 103.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 001102174.1_06529001_3 - 0.00057 19.2 0.4 0.00089 18.5 0.4 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001102174.1_06529001_3 - 0.067 13.0 0.2 0.15 11.8 0.2 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family NifU_N PF01592.14 001075683.2_06523001_1 - 1.3e-56 190.1 0.1 1.8e-56 189.6 0.1 1.2 1 0 0 1 1 1 1 NifU-like N terminal domain IL4 PF00727.16 001082519.1_21021001_1 - 3.2e-46 156.0 2.6 3.8e-46 155.7 2.6 1.1 1 0 0 1 1 1 1 Interleukin 4 p450 PF00067.20 001101652.1_21024001_3 - 3.2e-165 550.2 0.0 4.1e-165 549.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Kinesin PF00225.21 001078155.1_06529001_3 - 6.3e-111 370.4 0.0 1.2e-75 254.3 0.1 2.2 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.3 001078155.1_06529001_3 - 5.9e-27 94.3 0.0 1.6e-26 92.9 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding Kinesin_assoc PF16183.3 001078155.1_06529001_3 - 0.00094 19.2 3.6 0.0023 18.0 3.6 1.6 1 0 0 1 1 1 1 Kinesin-associated Fez1 PF06818.13 001078155.1_06529001_3 - 0.0037 17.6 10.5 0.0037 17.6 10.5 2.4 2 0 0 2 2 2 1 Fez1 ARA70 PF12489.6 001078155.1_06529001_3 - 4.5 7.3 12.5 38 4.3 12.5 2.2 1 1 0 1 1 1 0 Nuclear coactivator SOCS_box PF07525.14 001078155.1_06529001_3 - 5.4 7.3 7.4 13 6.1 7.4 1.7 1 0 0 1 1 1 0 SOCS box Septin PF00735.16 001076371.1_06525001_3 - 1.1e-124 415.1 0.1 1.5e-124 414.7 0.1 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 001076371.1_06525001_3 - 3.9e-06 26.8 0.0 8.3e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001076371.1_06525001_3 - 1.7e-05 24.7 0.1 0.00028 20.7 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001076371.1_06525001_3 - 0.0013 18.2 0.3 0.39 10.1 0.0 2.4 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Ras PF00071.20 001076371.1_06525001_3 - 0.023 14.2 0.0 0.041 13.4 0.0 1.3 1 0 0 1 1 1 0 Ras family Roc PF08477.11 001076371.1_06525001_3 - 0.039 14.0 0.0 0.072 13.2 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 001076371.1_06525001_3 - 0.073 13.3 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.4 001076371.1_06525001_3 - 0.12 12.0 0.1 0.25 10.9 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.4 001076371.1_06525001_3 - 0.15 12.2 0.0 0.45 10.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.25 001076371.1_06525001_3 - 0.17 12.3 0.0 0.41 11.0 0.0 1.6 1 0 0 1 1 1 0 ABC transporter Mito_carr PF00153.25 001075159.1_06525001_1 - 9.7e-61 201.6 0.8 6.4e-23 80.4 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein p450 PF00067.20 001111306.1_21024001_1 - 1.1e-134 449.6 0.0 1.2e-134 449.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 EF-hand_1 PF00036.30 001075976.2_06522001_3 - 3e-25 85.7 16.8 1.6e-08 33.3 0.9 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 001075976.2_06522001_3 - 1.3e-24 86.4 12.4 6.7e-14 52.0 2.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 001075976.2_06522001_3 - 4.1e-22 76.1 12.3 2.4e-06 26.9 0.2 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.4 001075976.2_06522001_3 - 2.6e-15 55.8 14.6 1.1e-10 40.9 0.8 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.4 001075976.2_06522001_3 - 2.4e-13 48.8 13.6 0.00025 20.3 0.7 4.5 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.4 001075976.2_06522001_3 - 1.6e-07 31.4 1.2 0.00046 20.3 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.5 001075976.2_06522001_3 - 0.00013 21.7 5.7 0.011 15.5 0.4 2.6 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.11 001075976.2_06522001_3 - 0.011 15.6 1.2 1.7 8.4 0.0 3.7 1 1 3 4 4 4 0 Caleosin related protein HTH_40 PF14493.4 001075976.2_06522001_3 - 0.034 14.5 1.8 8.2 6.9 1.8 2.3 1 1 0 1 1 1 0 Helix-turn-helix domain SPARC_Ca_bdg PF10591.7 001075976.2_06522001_3 - 0.093 12.9 5.3 0.97 9.6 1.3 2.4 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region MgtE_N PF03448.15 001075976.2_06522001_3 - 0.31 11.5 3.9 0.22 12.0 0.6 2.3 1 1 0 2 2 2 0 MgtE intracellular N domain DUF4834 PF16118.3 001075976.2_06522001_3 - 0.96 10.3 7.5 0.68 10.8 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) TFIID_30kDa PF03540.11 001098968.2_06522001_1 - 1.6e-26 91.9 0.0 2.3e-26 91.3 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit Bromo_TP PF07524.11 001098968.2_06522001_1 - 0.003 17.4 0.0 0.039 13.8 0.0 2.1 1 1 0 1 1 1 1 Bromodomain associated DUF4604 PF15377.4 001098968.2_06522001_1 - 0.023 15.0 14.0 0.037 14.4 14.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) DUF4604 PF15377.4 001098968.2_06522001_2 - 0.028 14.7 14.4 0.04 14.2 14.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) AP3D1 PF06375.9 001098968.2_06522001_2 - 0.24 11.5 18.8 0.31 11.2 18.8 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 SR-25 PF10500.7 001098968.2_06522001_2 - 1.8 8.0 29.0 2.3 7.6 29.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TFIIE_alpha PF02002.15 001103294.1_06526001_1 - 1.8e-36 124.0 0.9 1.8e-36 124.0 0.9 1.8 2 0 0 2 2 2 1 TFIIE alpha subunit TFIIE-A_C PF11521.6 001103294.1_06526001_1 - 4.2e-31 107.0 6.6 9.3e-31 105.9 6.6 1.6 1 0 0 1 1 1 1 C-terminal general transcription factor TFIIE alpha TF_Zn_Ribbon PF08271.10 001103294.1_06526001_1 - 2.4e-13 49.2 0.7 4.6e-13 48.3 0.7 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding RPA_interact_C PF14768.4 001076500.2_06522001_3 - 4.2e-19 68.8 7.3 7.7e-19 67.9 7.3 1.5 1 0 0 1 1 1 1 Replication protein A interacting C-terminal RPA_interact_N PF14766.4 001076500.2_06522001_3 - 1.5e-16 59.7 1.4 2.5e-16 59.0 1.4 1.4 1 0 0 1 1 1 1 Replication protein A interacting N-terminal RPA_interact_M PF14767.4 001076500.2_06522001_3 - 1.1e-15 57.9 11.0 1.8e-15 57.1 11.0 1.4 1 0 0 1 1 1 1 Replication protein A interacting middle Glyco_hydro_67C PF07477.10 001076500.2_06522001_3 - 0.058 12.8 0.3 0.084 12.3 0.3 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 C-terminus RNA_pol_Rpc4 PF05132.12 001040528.2_06523001_2 - 0.2 12.0 12.6 0.26 11.6 12.6 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 EIIBC-GUT_N PF03612.12 001040528.2_06523001_2 - 0.22 11.1 12.6 0.33 10.5 12.6 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Connexin PF00029.17 001040528.2_06523001_2 - 0.57 9.8 14.8 0.035 13.8 9.1 1.9 2 0 0 2 2 2 0 Connexin SpoIIP PF07454.9 001040528.2_06523001_2 - 8.1 5.7 16.0 11 5.3 16.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) SspB PF04386.11 001040528.2_06523001_2 - 8.8 6.1 9.7 12 5.6 9.7 1.2 1 0 0 1 1 1 0 Stringent starvation protein B 7tm_1 PF00001.19 001040528.2_06523001_3 - 0.0026 16.9 5.4 0.0026 16.9 5.4 1.9 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) Connexin PF00029.17 001040528.2_06523001_3 - 0.019 14.6 11.3 0.026 14.2 11.3 1.2 1 0 0 1 1 1 0 Connexin EOS1 PF12326.6 001040528.2_06523001_3 - 0.041 13.7 0.4 0.047 13.5 0.4 1.3 1 0 0 1 1 1 0 N-glycosylation protein VKG_Carbox PF05090.12 001040528.2_06523001_3 - 0.041 12.6 2.0 0.057 12.1 2.0 1.1 1 0 0 1 1 1 0 Vitamin K-dependent gamma-carboxylase Presenilin PF01080.15 001040528.2_06523001_3 - 0.11 11.1 1.2 0.12 11.0 1.2 1.1 1 0 0 1 1 1 0 Presenilin Folate_carrier PF01770.16 001040528.2_06523001_3 - 0.18 10.4 5.8 0.24 9.9 5.8 1.1 1 0 0 1 1 1 0 Reduced folate carrier CLN3 PF02487.15 001040528.2_06523001_3 - 0.3 10.0 3.1 0.38 9.6 3.1 1.1 1 0 0 1 1 1 0 CLN3 protein Eapp_C PF10238.7 001040528.2_06523001_3 - 0.3 11.0 9.3 0.45 10.4 9.3 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein ABC_export PF16962.3 001040528.2_06523001_3 - 8.9 4.5 16.2 12 4.1 16.2 1.1 1 0 0 1 1 1 0 Putative ABC exporter IZUMO PF15005.4 001110097.1_06522001_3 - 7e-31 107.6 0.2 9.9e-31 107.1 0.2 1.2 1 0 0 1 1 1 1 Izumo sperm-egg fusion, Ig domain-associated KRAB PF01352.25 001110097.1_06522001_3 - 2.5e-25 87.7 0.1 4.1e-25 87.1 0.1 1.4 1 0 0 1 1 1 1 KRAB box RhoGAP PF00620.25 001101988.2_06526001_1 - 2.4e-40 137.7 0.0 3.6e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain 7tm_1 PF00001.19 001081845.1_21023001_3 - 4.2e-40 137.5 13.7 5.7e-40 137.1 13.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 001081845.1_21023001_3 - 2.5e-06 26.9 1.4 2.5e-06 26.9 1.4 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.7 001081845.1_21023001_3 - 0.00011 21.5 9.8 0.00016 21.0 9.5 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srt PF10321.7 001081845.1_21023001_3 - 0.00015 20.7 18.4 0.028 13.3 3.8 2.5 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srt 7TM_GPCR_Srsx PF10320.7 001081845.1_21023001_3 - 0.0015 17.8 7.4 0.083 12.1 3.0 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx Cytochrom_B_N_2 PF13631.4 001081845.1_21023001_3 - 0.0035 17.2 1.0 0.011 15.6 0.1 2.1 2 0 0 2 2 2 1 Cytochrome b(N-terminal)/b6/petB 7tm_4 PF13853.4 001081845.1_21023001_3 - 0.049 13.2 9.0 0.33 10.5 9.0 1.9 1 1 0 1 1 1 0 Olfactory receptor RNA_pol_Rpc4 PF05132.12 001046192.2_06523001_1 - 0.015 15.6 20.9 0.023 15.0 20.9 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF913 PF06025.10 001046192.2_06523001_1 - 2.1 7.1 11.7 2.6 6.8 11.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DDHD PF02862.15 001046192.2_06523001_1 - 6.7 6.6 19.3 9.2 6.2 19.3 1.2 1 0 0 1 1 1 0 DDHD domain RNA_pol_Rpc4 PF05132.12 001046192.2_06523001_2 - 0.0032 17.8 17.6 0.0045 17.3 17.6 1.2 1 0 0 1 1 1 1 RNA polymerase III RPC4 SID-1_RNA_chan PF13965.4 001046192.2_06523001_2 - 5.9 5.1 4.9 6.6 4.9 4.9 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF913 PF06025.10 001046192.2_06523001_2 - 6.3 5.5 11.8 7.5 5.3 11.8 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) MRP-S23 PF10484.7 001046192.2_06523001_3 - 1.4e-47 161.0 0.0 1.4e-47 161.0 0.0 2.2 2 0 0 2 2 2 1 Mitochondrial ribosomal protein S23 RNA_pol_Rpc4 PF05132.12 001046192.2_06523001_3 - 2.5e-05 24.6 11.9 2.5e-05 24.6 11.9 2.1 2 0 0 2 2 2 1 RNA polymerase III RPC4 MRP-S25 PF13741.4 001046192.2_06523001_3 - 0.00013 21.5 0.0 0.00013 21.5 0.0 4.0 2 2 1 3 3 3 2 Mitochondrial ribosomal protein S25 Ctr PF04145.13 001046192.2_06523001_3 - 1.3 9.5 12.2 0.49 10.9 9.2 1.7 2 0 0 2 2 2 0 Ctr copper transporter family DUF1510 PF07423.9 001046192.2_06523001_3 - 1.4 8.1 36.1 0.035 13.4 29.9 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) Roc PF08477.11 001015612.1_06523001_3 - 5.8e-14 52.2 0.0 8.1e-14 51.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001015612.1_06523001_3 - 2.7e-11 43.2 0.0 3.8e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Arf PF00025.19 001015612.1_06523001_3 - 2.8e-08 33.3 0.0 4e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001015612.1_06523001_3 - 3.7e-05 23.1 0.0 5.3e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 001015612.1_06523001_3 - 0.0043 16.1 0.0 1.4 7.8 0.0 3.0 1 1 2 3 3 3 1 G-protein alpha subunit Gtr1_RagA PF04670.10 001015612.1_06523001_3 - 0.014 14.6 0.0 0.022 14.0 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region PduV-EutP PF10662.7 001015612.1_06523001_3 - 0.022 14.3 0.0 0.037 13.6 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.21 001015612.1_06523001_3 - 0.18 11.8 0.0 0.28 11.2 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase Synaptobrevin PF00957.19 001034290.2_06522001_3 - 2.3e-31 107.3 1.0 2.8e-31 107.0 1.0 1.1 1 0 0 1 1 1 1 Synaptobrevin Ferlin_C PF16165.3 001034290.2_06522001_3 - 0.0042 16.9 0.3 0.0059 16.4 0.3 1.2 1 0 0 1 1 1 1 Ferlin C-terminus DUF912 PF06024.10 001034290.2_06522001_3 - 0.018 15.2 0.2 0.026 14.7 0.2 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) MCU PF04678.11 001034290.2_06522001_3 - 0.06 13.3 0.0 0.078 13.0 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Sec20 PF03908.11 001034290.2_06522001_3 - 0.064 13.0 0.1 0.064 13.0 0.1 1.6 2 0 0 2 2 1 0 Sec20 TMCO5 PF14992.4 001034290.2_06522001_3 - 0.066 12.7 0.0 0.084 12.3 0.0 1.1 1 0 0 1 1 1 0 TMCO5 family DUF2207 PF09972.7 001034290.2_06522001_3 - 0.071 11.7 0.0 0.08 11.6 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Prominin PF05478.9 001034290.2_06522001_3 - 0.1 10.4 0.9 0.2 9.5 1.0 1.3 1 1 0 1 1 1 0 Prominin Baculo_F PF12259.6 001034290.2_06522001_3 - 0.13 10.6 0.8 0.16 10.3 0.8 1.1 1 0 0 1 1 1 0 Baculovirus F protein Baculo_11_kDa PF06143.9 001034290.2_06522001_3 - 0.3 10.6 2.0 0.49 9.9 2.0 1.3 1 0 0 1 1 1 0 Baculovirus 11 kDa family Use1 PF09753.7 001034290.2_06522001_3 - 0.45 10.0 2.4 0.59 9.6 2.4 1.1 1 0 0 1 1 1 0 Membrane fusion protein Use1 Sigma_reg_N PF13800.4 001034290.2_06522001_3 - 2.1 8.5 5.1 3.7 7.8 5.1 1.3 1 0 0 1 1 1 0 Sigma factor regulator N-terminal FAD_binding_4 PF01565.21 001103276.1_06526001_3 - 2.7e-14 52.9 0.0 4.6e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain RRP14 PF15459.4 001103276.1_06526001_3 - 9.4 6.8 20.9 3.9 8.0 15.1 2.9 3 0 0 3 3 3 0 60S ribosome biogenesis protein Rrp14 zf-CXXC PF02008.18 001046481.2_06525001_3 - 6.7e-30 102.7 77.1 4e-14 52.2 25.4 5.0 5 1 0 5 5 5 3 CXXC zinc finger domain MBD PF01429.17 001046481.2_06525001_3 - 1.2e-16 60.1 0.1 2.1e-16 59.2 0.1 1.4 1 0 0 1 1 1 1 Methyl-CpG binding domain RGS PF00615.17 001076327.1_06524001_2 - 2.7e-34 117.8 1.0 3.9e-34 117.3 1.0 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain RRM_1 PF00076.20 001046380.2_06524001_3 - 2.1e-19 69.0 0.0 3.6e-19 68.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1777 PF08648.10 001046380.2_06524001_3 - 0.00091 19.4 10.2 0.00091 19.4 10.2 3.0 2 1 0 2 2 2 1 Protein of unknown function (DUF1777) EOS1 PF12326.6 001046380.2_06524001_3 - 2.3 8.0 10.7 0.28 11.0 0.0 2.3 2 0 0 2 2 2 0 N-glycosylation protein A_deaminase PF00962.20 001075577.1_06524001_2 - 6.6e-39 134.0 0.1 8e-39 133.7 0.1 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase Amidohydro_1 PF01979.18 001075577.1_06524001_2 - 2.4e-06 27.0 0.0 3.8e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase family MFS_1 PF07690.14 001076808.2_06525001_3 - 6.1e-33 114.1 23.1 6.1e-33 114.1 23.1 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.22 001076808.2_06525001_3 - 8.7e-13 47.8 2.6 8.7e-13 47.8 2.6 2.4 2 0 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.18 001076808.2_06525001_3 - 2.2e-09 36.0 12.9 0.0012 17.2 0.1 4.3 2 2 2 4 4 4 4 Organic Anion Transporter Polypeptide (OATP) family MFS_2 PF13347.4 001076808.2_06525001_3 - 1.9e-07 29.9 3.6 0.0013 17.3 0.1 2.7 1 1 1 2 2 2 2 MFS/sugar transport protein DUF4724 PF15852.3 001078053.2_06521001_1 - 0.08 13.2 3.4 0.061 13.5 1.6 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4724) Connexin PF00029.17 001081891.1_21022001_1 - 7.7e-84 280.8 7.0 1.1e-83 280.3 7.0 1.2 1 0 0 1 1 1 1 Connexin SRCR PF00530.16 173899.2_06524001_2 - 1.3e-21 76.9 16.5 3.7e-08 33.6 0.7 4.2 4 0 0 4 4 4 3 Scavenger receptor cysteine-rich domain Comm PF15957.3 173899.2_06524001_2 - 0.0065 16.7 0.0 0.012 15.8 0.0 1.3 1 0 0 1 1 1 1 Commissureless Parathyroid PF01279.15 173954.2_06522001_2 - 6.5e-06 26.6 1.0 1.3e-05 25.6 1.0 1.5 1 1 0 1 1 1 1 Parathyroid hormone family ABC_ATPase PF09818.7 173954.2_06522001_2 - 0.025 13.3 0.0 0.032 12.9 0.0 1.1 1 0 0 1 1 1 0 Predicted ATPase of the ABC class Arf PF00025.19 001080303.1_06524001_3 - 1.7e-70 235.9 0.3 3.7e-70 234.8 0.0 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.11 001080303.1_06524001_3 - 9.9e-14 51.5 0.2 1.1e-12 48.1 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001080303.1_06524001_3 - 1e-11 44.6 0.0 1.9e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Ras family SRPRB PF09439.8 001080303.1_06524001_3 - 6.1e-11 41.9 0.0 1.2e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 001080303.1_06524001_3 - 4.4e-10 39.1 0.1 1.2e-07 31.2 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit zf-B_box PF00643.22 001080303.1_06524001_3 - 4.9e-07 29.7 6.0 4.9e-07 29.7 6.0 3.9 4 0 0 4 4 3 2 B-box zinc finger zf-RING_5 PF14634.4 001080303.1_06524001_3 - 1.8e-06 27.6 1.9 1.8e-06 27.6 1.9 4.2 3 1 0 3 3 2 1 zinc-RING finger domain Gtr1_RagA PF04670.10 001080303.1_06524001_3 - 2.4e-06 26.9 0.6 3.9e-06 26.2 0.0 1.6 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region zf-RING_UBOX PF13445.4 001080303.1_06524001_3 - 2.9e-06 27.0 5.4 2.9e-06 27.0 5.4 2.9 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_2 PF13639.4 001080303.1_06524001_3 - 2.6e-05 24.3 3.4 2.6e-05 24.3 3.4 4.2 5 0 0 5 5 3 1 Ring finger domain MMR_HSR1 PF01926.21 001080303.1_06524001_3 - 0.00052 20.0 0.1 0.0017 18.3 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase zf-C3HC4 PF00097.23 001080303.1_06524001_3 - 0.0015 18.2 1.7 0.0015 18.2 1.7 3.6 4 0 0 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001080303.1_06524001_3 - 0.0086 15.8 3.7 0.0086 15.8 3.7 3.4 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 001080303.1_06524001_3 - 0.0087 15.8 3.3 0.0087 15.8 3.3 3.2 4 0 0 4 4 3 1 Prokaryotic RING finger family 4 SAM_decarbox PF01536.14 173990.2_06525001_3 - 1.3e-123 412.4 0.1 1.7e-123 412.0 0.1 1.1 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase zf-CCCH PF00642.22 001105430.1_06528001_2 - 6.1e-05 22.7 1.9 6.1e-05 22.7 1.9 4.2 4 0 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C2H2_jaz PF12171.6 001105430.1_06528001_2 - 0.0016 18.5 8.3 0.0032 17.6 6.8 2.3 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding TPR_2 PF07719.15 001105430.1_06528001_2 - 0.011 15.6 0.1 10 6.4 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.26 001105430.1_06528001_2 - 0.013 15.2 1.0 0.25 11.1 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-met PF12874.5 001105430.1_06528001_2 - 0.096 13.0 6.5 0.15 12.4 5.2 2.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type EOS1 PF12326.6 001025341.3_06522001_1 - 0.35 10.6 2.1 0.31 10.8 2.1 1.1 1 0 0 1 1 1 0 N-glycosylation protein Ribosomal_L31e PF01198.17 001025341.3_06522001_2 - 3.6e-53 177.6 0.9 3.6e-53 177.6 0.9 2.0 2 0 0 2 2 2 1 Ribosomal protein L31e RNA_polI_A34 PF08208.9 001025341.3_06522001_2 - 0.15 12.1 35.2 0.026 14.5 31.9 1.5 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 EOS1 PF12326.6 001025341.3_06522001_2 - 0.27 11.0 2.8 0.27 11.0 2.8 1.2 1 0 0 1 1 1 0 N-glycosylation protein Connexin PF00029.17 001025341.3_06522001_2 - 3.4 7.3 10.5 2.7 7.6 9.3 1.5 2 0 0 2 2 2 0 Connexin YqfQ PF14181.4 001025341.3_06522001_2 - 3.6 7.6 15.5 0.95 9.5 12.5 1.5 2 0 0 2 2 2 0 YqfQ-like protein RNA_polI_A34 PF08208.9 001025341.3_06522001_3 - 0.0018 18.3 26.6 0.002 18.2 26.6 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 EOS1 PF12326.6 001025341.3_06522001_3 - 0.23 11.2 1.7 0.22 11.3 1.7 1.1 1 0 0 1 1 1 0 N-glycosylation protein Folate_carrier PF01770.16 001025341.3_06522001_3 - 6.4 5.3 5.0 7.4 5.1 5.0 1.0 1 0 0 1 1 1 0 Reduced folate carrier Laminin_EGF PF00053.22 001081768.1_21028001_2 - 2e-43 146.1 154.2 1.2e-10 41.3 12.5 8.9 9 0 0 9 9 9 8 Laminin EGF domain Laminin_B PF00052.16 001081768.1_21028001_2 - 4.5e-30 104.2 0.8 6.4e-29 100.4 0.0 3.2 3 1 0 3 3 3 1 Laminin B (Domain IV) MCPsignal PF00015.19 001081768.1_21028001_2 - 0.0066 16.1 4.2 0.0066 16.1 4.2 4.0 2 1 2 4 4 4 1 Methyl-accepting chemotaxis protein (MCP) signalling domain Alanine_zipper PF11839.6 001081768.1_21028001_2 - 0.094 12.9 0.1 0.094 12.9 0.1 6.9 5 2 1 7 7 7 0 Alanine-zipper, major outer membrane lipoprotein DUF3287 PF11690.6 001081768.1_21028001_2 - 0.33 10.5 2.4 0.41 10.2 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3287) TFR_dimer PF04253.13 001081768.1_21028001_2 - 0.92 9.5 3.2 2.7 8.0 1.4 2.6 1 1 1 2 2 2 0 Transferrin receptor-like dimerisation domain SnAPC_2_like PF11035.6 001034516.1_06523001_2 - 4.9e-147 490.4 0.1 5.7e-147 490.2 0.1 1.0 1 0 0 1 1 1 1 Small nuclear RNA activating complex subunit 2, SNAP190 Myb 7tm_1 PF00001.19 174330.1_06523001_1 - 2.5e-47 161.2 20.8 3.2e-47 160.9 20.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 174330.1_06523001_1 - 2.4e-05 23.7 23.6 3.5e-05 23.2 23.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TFIID-31kDa PF02291.13 001075975.1_06523001_3 - 1.3e-50 170.4 0.0 1.8e-50 170.0 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CENP-S PF15630.4 001075975.1_06523001_3 - 3.5e-06 27.2 0.1 6.6e-06 26.3 0.1 1.4 1 0 0 1 1 1 1 CENP-S protein AAA_18 PF13238.4 001075975.1_06523001_3 - 6.4e-05 23.3 0.1 0.00013 22.4 0.1 1.4 1 0 0 1 1 1 1 AAA domain Bromo_TP PF07524.11 001075975.1_06523001_3 - 0.00014 21.7 0.0 0.00024 20.9 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated AAA_17 PF13207.4 001075975.1_06523001_3 - 0.00027 21.2 0.1 0.00027 21.2 0.1 1.6 2 0 0 2 2 1 1 AAA domain Histone PF00125.22 001075975.1_06523001_3 - 0.00078 19.7 0.3 0.00078 19.7 0.3 1.7 2 0 0 2 2 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.4 001075975.1_06523001_3 - 0.0049 16.8 0.1 0.0094 15.9 0.1 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold AAA PF00004.27 001075975.1_06523001_3 - 0.016 15.5 0.0 0.029 14.7 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.4 001075975.1_06523001_3 - 0.023 14.8 0.0 0.036 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain SKI PF01202.20 001075975.1_06523001_3 - 0.029 14.3 0.0 0.051 13.6 0.0 1.3 1 0 0 1 1 1 0 Shikimate kinase AAA_33 PF13671.4 001075975.1_06523001_3 - 0.15 12.1 0.4 0.52 10.3 0.4 1.9 1 1 0 1 1 1 0 AAA domain Ig_2 PF13895.4 001099764.1_21023001_3 - 8.3e-12 45.2 0.1 0.00016 21.8 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001099764.1_21023001_3 - 2.3e-11 44.0 0.0 1.8e-05 25.1 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001099764.1_21023001_3 - 6.2e-08 32.6 0.1 3.2e-05 23.9 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain LLGL PF08366.11 001099098.1_06528001_3 - 2.2e-40 137.1 0.0 4.3e-40 136.1 0.0 1.5 1 0 0 1 1 1 1 LLGL2 WD40 PF00400.30 001099098.1_06528001_3 - 5.9e-05 23.6 3.7 0.027 15.2 0.1 4.4 4 1 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001099098.1_06528001_3 - 0.0039 17.3 0.0 9.3 6.5 0.0 4.3 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N PF14655.4 001099098.1_06528001_3 - 0.023 13.8 0.0 3.3 6.7 0.0 2.9 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus PQQ_3 PF13570.4 001099098.1_06528001_3 - 0.029 14.7 0.1 60 4.2 0.0 4.2 4 0 0 4 4 4 0 PQQ-like domain Lgl_C PF08596.8 001099098.1_06528001_3 - 0.042 12.4 0.0 0.56 8.7 0.0 2.5 3 0 0 3 3 3 0 Lethal giant larvae(Lgl) like, C-terminal SP_C-Propep PF08999.8 001078078.1_06523001_3 - 0.051 13.2 0.7 0.14 11.9 0.7 1.7 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide MARVEL PF01284.21 001075807.1_06523001_3 - 1.7e-05 24.8 17.3 2.6e-05 24.1 17.3 1.2 1 0 0 1 1 1 1 Membrane-associating domain PMT_4TMC PF16192.3 001075807.1_06523001_3 - 0.00029 20.4 0.8 0.00045 19.8 0.8 1.2 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase GWT1 PF06423.10 001075807.1_06523001_3 - 0.046 13.7 0.5 0.14 12.2 0.0 1.9 2 0 0 2 2 2 0 GWT1 MgtE PF01769.14 001075807.1_06523001_3 - 0.067 13.4 7.0 0.066 13.5 1.1 2.1 2 0 0 2 2 2 0 Divalent cation transporter DUF2207 PF09972.7 001075807.1_06523001_3 - 1.5 7.4 0.0 1.5 7.4 0.0 2.8 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) SdpI PF13630.4 001075807.1_06523001_3 - 9.3 6.3 8.3 0.81 9.7 1.1 2.1 2 0 0 2 2 2 0 SdpI/YhfL protein family Forkhead PF00250.16 001083597.1_21024001_1 - 1.1e-39 134.4 0.1 1.8e-39 133.8 0.1 1.3 1 0 0 1 1 1 1 Forkhead domain Pkinase PF00069.23 001075920.2_06524001_2 - 2.6e-64 217.0 0.0 3.5e-64 216.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001075920.2_06524001_2 - 8.4e-30 103.8 0.0 1.2e-29 103.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 001075920.2_06524001_2 - 7.4e-05 22.1 0.1 0.00012 21.4 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001075920.2_06524001_2 - 0.061 13.1 0.3 5.1 6.8 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Mis12 PF05859.10 001076969.1_06524001_3 - 2.8e-28 98.5 0.8 5.1e-28 97.7 0.8 1.4 1 0 0 1 1 1 1 Mis12 protein MFS_1 PF07690.14 001024486.1_06526001_1 - 4.1e-41 140.9 25.8 1.3e-35 122.8 16.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.18 001024486.1_06526001_1 - 1.9e-06 26.4 0.3 1.9e-06 26.4 0.3 2.6 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.5 001024486.1_06526001_1 - 0.00069 18.4 8.0 0.00069 18.4 8.0 2.1 2 0 0 2 2 2 1 MFS_1 like family PMT PF02366.16 001080330.3_06527001_3 - 4e-91 304.8 20.0 9.4e-91 303.6 20.0 1.7 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.3 001080330.3_06527001_3 - 1.2e-51 175.0 8.0 1.2e-51 175.0 8.0 2.5 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.17 001080330.3_06527001_3 - 7.5e-15 55.1 0.0 1.2e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 MIR domain RNA_pol_Rpb2_6 PF00562.26 001100292.1_06528001_1 - 1.7e-117 392.7 0.0 5e-117 391.1 0.0 1.7 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.13 001100292.1_06528001_1 - 9.2e-37 126.4 0.0 1.3e-36 125.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.14 001100292.1_06528001_1 - 1.5e-27 95.4 0.0 2.8e-27 94.5 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.18 001100292.1_06528001_1 - 2e-21 76.0 0.0 4.8e-21 74.8 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpa2_4 PF06883.10 001100292.1_06528001_1 - 4.2e-19 68.2 0.0 8.2e-19 67.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_2 PF04561.12 001100292.1_06528001_1 - 2.1e-12 47.0 0.0 3.3e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 DUF1186 PF06685.9 001100292.1_06528001_1 - 0.16 11.2 0.0 0.28 10.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1186) Phage_holin_1 PF04531.11 001100292.1_06528001_2 - 0.14 12.6 0.7 24 5.4 0.0 2.4 2 0 0 2 2 2 0 Bacteriophage holin IL8 PF00048.18 001034345.1_06522001_1 - 1.9e-19 69.4 0.0 2.9e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Reprolysin PF01421.17 001001156.1_06527001_1 - 2.8e-73 246.0 0.0 2.8e-73 246.0 0.0 1.8 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 001001156.1_06527001_1 - 1.2e-33 115.8 2.3 1.2e-33 115.8 2.3 3.7 3 0 0 3 3 3 1 ADAM cysteine-rich Pep_M12B_propep PF01562.17 001001156.1_06527001_1 - 7.9e-27 94.1 0.0 2e-26 92.8 0.0 1.6 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 001001156.1_06527001_1 - 1.5e-23 83.9 0.0 2.7e-23 83.0 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Disintegrin PF00200.21 001001156.1_06527001_1 - 2.7e-19 69.6 27.9 2.7e-19 69.6 27.9 5.2 5 0 0 5 5 5 1 Disintegrin Reprolysin_3 PF13582.4 001001156.1_06527001_1 - 3.2e-14 53.4 0.0 5.6e-14 52.6 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 001001156.1_06527001_1 - 1e-13 51.5 0.0 1.7e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 001001156.1_06527001_1 - 2e-13 50.3 0.0 3.2e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.7 001001156.1_06527001_1 - 0.081 11.7 0.1 0.13 11.1 0.1 1.2 1 0 0 1 1 1 0 Peptidase M66 Zincin_1 PF06262.9 001001156.1_06527001_1 - 0.13 12.2 0.1 0.27 11.2 0.1 1.4 1 0 0 1 1 1 0 Zinicin-like metallopeptidase Pkinase PF00069.23 001075413.1_06527001_3 - 1.5e-72 244.0 0.0 2e-72 243.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001075413.1_06527001_3 - 2.4e-34 118.7 0.0 3.3e-34 118.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001075413.1_06527001_3 - 6.3e-06 25.6 0.0 4.2e-05 22.9 0.0 2.0 1 1 1 2 2 2 1 Kinase-like APH PF01636.21 001075413.1_06527001_3 - 0.00028 20.8 2.0 0.27 11.0 0.0 3.0 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.12 001075413.1_06527001_3 - 0.00054 19.2 0.0 0.00096 18.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 001075413.1_06527001_3 - 0.019 14.5 0.1 2.3 7.6 0.1 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Lectin_C PF00059.19 174014.2_06524001_3 - 1e-15 58.3 8.2 1.6e-15 57.6 8.2 1.3 1 0 0 1 1 1 1 Lectin C-type domain Ammonium_transp PF00909.19 174723.2_06523001_2 - 1.8e-50 171.7 22.2 2.7e-39 134.9 17.8 2.0 1 1 1 2 2 2 2 Ammonium Transporter Family SOUL PF04832.10 001075985.2_06523001_2 - 3.3e-36 124.8 0.0 4.2e-36 124.5 0.0 1.1 1 0 0 1 1 1 1 SOUL heme-binding protein Crisp PF08562.8 001081873.1_21023001_2 - 3.1e-17 62.8 19.9 1.4e-16 60.6 19.9 2.3 1 0 0 1 1 1 1 Crisp CAP PF00188.24 001081873.1_21023001_2 - 1.2e-14 55.1 0.6 2.3e-14 54.2 0.6 1.5 1 0 0 1 1 1 1 Cysteine-rich secretory protein family NHS PF15273.4 001105461.1_06523001_1 - 0.071 12.1 1.9 0.1 11.6 1.9 1.2 1 0 0 1 1 1 0 NHS-like Glucosamine_iso PF01182.18 001075356.1_06524001_3 - 4.2e-20 72.5 0.0 5.7e-20 72.0 0.0 1.1 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Arm PF00514.21 001083504.1_06524001_3 - 1.4e-10 40.7 0.2 1.3e-05 24.9 0.1 2.7 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.4 001083504.1_06524001_3 - 0.018 15.3 0.0 0.16 12.3 0.0 2.1 1 1 1 2 2 2 0 HEAT repeats Arm_2 PF04826.11 001083504.1_06524001_3 - 0.055 12.8 0.0 0.19 11.0 0.0 1.7 1 1 1 2 2 2 0 Armadillo-like HEAT PF02985.20 001083504.1_06524001_3 - 0.06 13.5 0.1 1.6 9.0 0.0 2.6 2 0 0 2 2 2 0 HEAT repeat PRKCSH-like PF12999.5 176662.1_06525001_2 - 9.8e-42 142.6 7.4 9.8e-42 142.6 7.4 1.7 2 1 0 2 2 2 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.4 176662.1_06525001_2 - 1.4e-20 73.5 0.0 2.6e-20 72.5 0.0 1.4 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.11 176662.1_06525001_2 - 1.9e-09 38.2 0.3 1.9e-09 38.2 0.3 2.2 2 0 0 2 2 1 1 Glucosidase II beta subunit-like protein EF-hand_5 PF13202.4 176662.1_06525001_2 - 1.3e-07 30.7 0.3 0.00055 19.2 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.30 176662.1_06525001_2 - 0.00015 20.9 0.1 0.21 11.1 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 176662.1_06525001_2 - 0.00055 19.5 0.3 0.24 11.3 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.4 176662.1_06525001_2 - 0.0064 16.8 0.5 1.6 9.2 0.1 2.7 2 0 0 2 2 2 1 EF-hand domain pair Ldl_recept_a PF00057.16 176662.1_06525001_2 - 0.014 15.4 2.4 0.014 15.4 2.4 2.9 2 1 1 3 3 2 0 Low-density lipoprotein receptor domain class A YjhX_toxin PF09857.7 176662.1_06525001_2 - 0.12 12.2 0.6 0.23 11.3 0.6 1.3 1 0 0 1 1 1 0 Putative toxin of bacterial toxin-antitoxin pair EF-hand_8 PF13833.4 176662.1_06525001_2 - 0.2 11.3 0.9 21 4.9 0.2 2.5 2 0 0 2 2 2 0 EF-hand domain pair Ebola_NP PF05505.10 176662.1_06525001_2 - 1.4 7.0 10.1 2.3 6.3 10.1 1.3 1 0 0 1 1 1 0 Ebola nucleoprotein CENP-B_dimeris PF09026.8 176662.1_06525001_2 - 5.3 7.4 13.8 15 5.9 13.8 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain TMEM251 PF15190.4 001077132.1_06524001_3 - 1.5e-68 228.5 2.1 2.4e-68 227.9 2.1 1.3 1 0 0 1 1 1 1 Transmembrane protein 251 DUF4064 PF13273.4 001077132.1_06524001_3 - 0.02 15.1 0.0 0.046 14.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) Mago_nashi PF02792.12 001034245.2_06522001_3 - 1.1e-79 265.3 0.2 1.4e-79 265.0 0.2 1.1 1 0 0 1 1 1 1 Mago nashi protein Adaptin_N PF01602.18 001075125.1_06527001_1 - 2.5e-162 541.0 14.1 3.2e-162 540.6 14.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.5 001075125.1_06527001_1 - 1.7e-67 226.3 14.2 1.7e-65 219.9 1.6 3.9 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.8 001075125.1_06527001_1 - 7.2e-38 129.0 0.1 2.7e-37 127.2 0.1 2.1 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.4 001075125.1_06527001_1 - 3e-20 72.3 8.5 7.9e-06 26.0 0.0 6.8 4 2 3 8 8 8 5 HEAT repeats HEAT PF02985.20 001075125.1_06527001_1 - 2.4e-12 45.8 8.9 0.0075 16.3 0.1 7.7 7 0 0 7 7 7 3 HEAT repeat Alpha_adaptinC2 PF02883.18 001075125.1_06527001_1 - 1.2e-10 41.6 1.8 1.2e-10 41.5 0.4 1.8 2 0 0 2 2 1 1 Adaptin C-terminal domain Arm PF00514.21 001075125.1_06527001_1 - 1.1e-07 31.4 2.6 0.022 14.7 0.0 5.2 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat Cnd3 PF12719.5 001075125.1_06527001_1 - 4e-07 29.4 4.4 1.3e-05 24.5 0.3 2.7 2 1 0 2 2 2 2 Nuclear condensing complex subunits, C-term domain RTP1_C1 PF10363.7 001075125.1_06527001_1 - 0.00017 21.6 5.4 0.88 9.6 0.0 5.2 2 2 1 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.6 001075125.1_06527001_1 - 0.00023 20.7 2.3 1.3 8.4 0.1 4.3 2 2 2 4 4 4 2 CLASP N terminal Arm_2 PF04826.11 001075125.1_06527001_1 - 0.0017 17.7 1.3 0.045 13.1 0.2 2.6 1 1 1 2 2 2 1 Armadillo-like HEAT_EZ PF13513.4 001075125.1_06527001_1 - 0.0048 17.2 6.5 7.5 7.0 0.0 6.3 7 0 0 7 7 7 1 HEAT-like repeat Sec7_N PF12783.5 001075125.1_06527001_1 - 0.029 14.2 0.3 0.029 14.2 0.3 3.8 5 1 1 6 6 6 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Suppressor_APC PF11414.6 001082467.1_06523001_2 - 3e-23 81.5 5.0 5.2e-23 80.8 5.0 1.4 1 0 0 1 1 1 1 Adenomatous polyposis coli tumour suppressor protein RPN7 PF10602.7 001034649.2_06523001_2 - 5.7e-62 208.4 2.0 5.7e-62 208.4 2.0 1.7 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.25 001034649.2_06523001_2 - 2.8e-17 63.0 0.2 8.8e-17 61.4 0.0 1.9 2 0 0 2 2 2 1 PCI domain PLA2_B PF01735.16 001081843.1_21025001_1 - 8.6e-148 492.6 0.0 1.1e-147 492.3 0.0 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain C2 PF00168.28 001081843.1_21025001_1 - 1.8e-16 60.1 0.1 4.4e-16 58.9 0.1 1.6 1 0 0 1 1 1 1 C2 domain LRR_4 PF12799.5 001077979.2_06524001_1 - 0.0076 16.5 17.7 1.8 9.0 1.0 5.3 5 1 0 5 5 5 3 Leucine Rich repeats (2 copies) Arrestin_N PF00339.27 174243.3_06524001_1 - 1.8e-46 157.7 0.0 1.2e-41 142.1 0.0 2.2 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.20 174243.3_06524001_1 - 1.7e-26 93.1 0.1 3.7e-26 92.0 0.1 1.6 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain BatD PF13584.4 174243.3_06524001_1 - 0.064 12.0 0.1 0.088 11.6 0.1 1.1 1 0 0 1 1 1 0 Oxygen tolerance AP3B1_C PF14796.4 174243.3_06524001_1 - 0.085 13.0 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Clathrin-adaptor complex-3 beta-1 subunit C-terminal TSC22 PF01166.16 001075860.2_06523001_2 - 1.1e-27 96.0 0.2 1.5e-27 95.5 0.2 1.2 1 0 0 1 1 1 1 TSC-22/dip/bun family DUF972 PF06156.11 001075860.2_06523001_2 - 0.013 16.0 0.3 0.02 15.4 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF972) K-box PF01486.15 001075860.2_06523001_2 - 0.015 15.4 0.2 0.022 14.8 0.2 1.1 1 0 0 1 1 1 0 K-box region ZapB PF06005.10 001075860.2_06523001_2 - 0.033 14.5 0.5 0.05 13.9 0.5 1.2 1 0 0 1 1 1 0 Cell division protein ZapB DivIC PF04977.13 001075860.2_06523001_2 - 0.051 13.2 0.4 0.082 12.5 0.4 1.2 1 0 0 1 1 1 0 Septum formation initiator Defensin_4 PF07936.10 001075860.2_06523001_2 - 0.058 13.1 1.2 0.058 13.1 1.2 2.0 2 0 0 2 2 2 0 Potassium-channel blocking toxin DUF1658 PF07871.9 001075860.2_06523001_2 - 0.15 12.0 5.8 0.21 11.4 2.8 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1658) BTB PF00651.29 001083384.1_06524001_2 - 9.1e-38 128.8 0.0 5.3e-18 65.1 0.0 3.2 2 1 1 3 3 3 2 BTB/POZ domain Ank_2 PF12796.5 001083384.1_06524001_2 - 1.1e-08 35.3 0.0 5.9e-08 33.1 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001083384.1_06524001_2 - 1.7e-07 31.5 0.7 1.9e-06 28.2 0.0 2.8 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.4 001083384.1_06524001_2 - 4.7e-07 29.9 0.1 1.9e-06 28.0 0.1 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 001083384.1_06524001_2 - 2.9e-06 27.1 0.6 0.0086 16.4 0.1 3.6 4 0 0 4 4 4 2 Ankyrin repeat BACK PF07707.13 001083384.1_06524001_2 - 0.00032 20.6 0.0 0.00096 19.1 0.0 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch Ank PF00023.28 001083384.1_06524001_2 - 0.0011 19.2 0.2 0.036 14.4 0.1 3.0 3 0 0 3 3 3 1 Ankyrin repeat DUF3342 PF11822.6 001083384.1_06524001_2 - 0.06 13.4 0.0 7.5 6.7 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) DUF3322 PF11795.6 001083384.1_06524001_3 - 0.12 12.3 2.3 0.11 12.3 1.0 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) p450 PF00067.20 174529.2_06524001_3 - 1.2e-134 449.4 0.0 1.4e-134 449.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Thiolase_N PF00108.21 001046075.1_06524001_3 - 1.7e-96 322.4 1.8 2.5e-96 321.9 1.8 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.16 001046075.1_06524001_3 - 5.3e-48 161.6 1.1 1.6e-47 160.0 0.6 2.0 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.24 001046075.1_06524001_3 - 1.7e-06 27.7 3.9 1.1e-05 25.0 1.5 2.8 2 1 1 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III_C PF08541.8 001046075.1_06524001_3 - 0.14 12.2 1.1 0.44 10.6 0.1 2.4 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.8 001046075.1_06524001_3 - 0.28 11.0 4.1 12 5.7 0.2 2.8 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III OAS1_C PF10421.7 001081797.1_21026001_1 - 6.2e-78 260.4 0.6 9.5e-78 259.8 0.6 1.3 1 0 0 1 1 1 1 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus ubiquitin PF00240.21 001081797.1_21026001_1 - 8.2e-21 73.4 0.0 2.8e-16 58.9 0.0 2.5 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.6 001081797.1_21026001_1 - 9.3e-05 22.1 0.0 0.00029 20.5 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like SCAN PF02023.15 001081797.1_21026001_1 - 0.0003 20.4 0.4 0.001 18.7 0.4 1.8 1 0 0 1 1 1 1 SCAN domain NTP_transf_2 PF01909.21 001081797.1_21026001_1 - 0.0058 16.8 0.0 0.015 15.4 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Ubiquitin_2 PF14560.4 001081797.1_21026001_1 - 0.14 12.5 0.0 0.66 10.3 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin-like domain Rap_GAP PF02145.13 001077872.2_06526001_2 - 2.5e-69 232.4 0.0 4.6e-69 231.6 0.0 1.5 1 0 0 1 1 1 1 Rap/ran-GAP CNH PF00780.20 001077872.2_06526001_2 - 2.7e-49 168.1 0.0 4.1e-49 167.5 0.0 1.2 1 0 0 1 1 1 1 CNH domain ubiquitin PF00240.21 001076291.1_06524001_2 - 5.2e-08 32.4 0.1 1.3e-07 31.1 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin family BAG PF02179.14 001076291.1_06524001_2 - 5.3e-07 29.8 4.6 1.1e-06 28.8 4.6 1.6 1 0 0 1 1 1 1 BAG domain Amidase PF01425.19 001076291.1_06524001_2 - 0.1 11.4 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 Amidase PhoU_div PF01865.14 001076291.1_06524001_2 - 0.11 11.6 3.4 0.18 11.0 3.4 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF47 BPS PF08947.8 001011681.3_06526001_3 - 2e-28 97.8 0.1 4.1e-28 96.8 0.1 1.6 1 0 0 1 1 1 1 BPS (Between PH and SH2) SH2 PF00017.22 001011681.3_06526001_3 - 6.8e-16 58.0 0.1 1.3e-15 57.0 0.1 1.5 1 0 0 1 1 1 1 SH2 domain RA PF00788.21 001011681.3_06526001_3 - 2e-14 53.9 0.1 5.1e-14 52.5 0.1 1.7 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain PH PF00169.27 001011681.3_06526001_3 - 7.8e-10 39.1 0.1 2.3e-09 37.6 0.0 1.9 2 0 0 2 2 2 1 PH domain Reo_sigmaC PF04582.10 001075763.2_06524001_1 - 0.25 10.6 3.7 3.3 6.9 0.2 2.4 2 0 0 2 2 2 0 Reovirus sigma C capsid protein B9-C2 PF07162.9 001040593.2_06522001_3 - 1.2e-61 207.7 1.0 1.4e-61 207.5 0.1 1.5 2 0 0 2 2 2 1 Ciliary basal body-associated, B9 protein adh_short PF00106.23 001046294.1_06523001_1 - 2e-37 128.4 0.0 2.6e-37 128.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001046294.1_06523001_1 - 2.5e-29 102.4 0.0 3.2e-29 102.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001046294.1_06523001_1 - 4.3e-07 29.9 0.1 1.2e-06 28.5 0.0 1.7 2 0 0 2 2 2 1 KR domain THF_DHG_CYH_C PF02882.17 001046294.1_06523001_1 - 0.0023 17.2 0.1 0.0038 16.4 0.1 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Epimerase PF01370.19 001046294.1_06523001_1 - 0.082 12.2 0.0 0.31 10.3 0.0 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF5042 PF16445.3 001046294.1_06523001_1 - 0.099 10.9 0.0 0.14 10.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5042) DUF106 PF01956.14 001046294.1_06523001_2 - 0.59 9.7 6.2 0.81 9.3 6.2 1.2 1 0 0 1 1 1 0 Integral membrane protein DUF106 DUF4770 PF15994.3 001046294.1_06523001_2 - 2 8.5 12.5 2.6 8.1 12.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Connexin PF00029.17 001046294.1_06523001_2 - 5.1 6.7 9.2 6.9 6.2 9.2 1.1 1 0 0 1 1 1 0 Connexin Ly49 PF08391.8 001081830.1_21023001_2 - 6.6e-51 171.5 5.0 6.6e-51 171.5 5.0 1.8 2 0 0 2 2 2 1 Ly49-like protein, N-terminal region Lectin_C PF00059.19 001081830.1_21023001_2 - 2.2e-13 50.8 5.1 2.2e-13 50.8 5.1 1.9 2 0 0 2 2 2 1 Lectin C-type domain Cadherin_C_2 PF16492.3 001081830.1_21023001_2 - 1.1 9.9 3.8 6.9 7.4 3.8 2.4 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal WD40 PF00400.30 001098959.1_06528001_2 - 8.4e-10 39.0 15.7 0.38 11.6 0.0 7.5 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001098959.1_06528001_2 - 4.8e-09 36.3 1.8 0.34 11.1 0.0 5.5 5 1 2 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain DUF1725 PF08333.9 001098959.1_06528001_3 - 0.00069 19.1 0.6 0.0016 17.9 0.6 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) Casein PF00363.16 001081852.1_21023001_2 - 1.6e-23 83.0 7.7 1.6e-23 83.0 7.7 2.9 2 1 0 2 2 2 1 Casein tRNA-synt_1c PF00749.19 001081852.1_21023001_2 - 0.048 12.4 0.0 0.07 11.9 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain DUF4659 PF15558.4 001076193.2_06525001_2 - 7.4e-135 449.5 81.7 7.4e-135 449.5 81.7 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4659) Collectrin PF16959.3 001076193.2_06525001_2 - 8 6.0 7.1 4.8 6.7 1.4 2.7 2 1 1 3 3 3 0 Renal amino acid transporter EOS1 PF12326.6 001014870.3_06525001_1 - 0.47 10.2 2.1 0.67 9.7 2.1 1.3 1 0 0 1 1 1 0 N-glycosylation protein Presenilin PF01080.15 001014870.3_06525001_1 - 2.9 6.4 5.4 4.5 5.8 5.4 1.2 1 0 0 1 1 1 0 Presenilin DUF1356 PF07092.10 001014870.3_06525001_2 - 8.2e-112 372.0 2.2 1.1e-111 371.5 2.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1356) EOS1 PF12326.6 001014870.3_06525001_2 - 0.61 9.9 3.4 1.2 9.0 3.4 1.5 1 0 0 1 1 1 0 N-glycosylation protein 6PF2K PF01591.16 001077837.2_06529001_2 - 3e-107 356.9 0.2 4.3e-107 356.4 0.2 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.20 001077837.2_06529001_2 - 8.8e-41 139.6 0.0 1.4e-40 139.0 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.4 001077837.2_06529001_2 - 7.4e-07 29.3 0.0 1.3e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.8 001077837.2_06529001_2 - 0.00012 21.5 0.1 0.00019 20.8 0.1 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 SRP54 PF00448.20 001077837.2_06529001_2 - 0.25 10.8 0.0 0.38 10.2 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Kunitz_BPTI PF00014.21 001012683.2_06523001_2 - 1.1e-17 63.8 10.5 2.2e-17 62.9 10.5 1.5 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Trypsin PF00089.24 001076538.1_06527001_1 - 6.4e-67 225.5 0.0 1e-66 224.8 0.0 1.3 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 001076538.1_06527001_1 - 1.3e-34 118.7 0.0 5.7e-20 71.6 0.2 2.5 2 0 0 2 2 2 2 CUB domain Ldl_recept_a PF00057.16 001076538.1_06527001_1 - 4.3e-34 116.3 69.4 1.6e-10 40.9 12.1 4.8 5 0 0 5 5 5 4 Low-density lipoprotein receptor domain class A SEA PF01390.18 001076538.1_06527001_1 - 9.5e-13 48.2 0.1 1.7e-12 47.4 0.1 1.4 1 0 0 1 1 1 1 SEA domain CUB_2 PF02408.18 001076538.1_06527001_1 - 2.7e-05 23.8 0.3 7.3e-05 22.4 0.3 1.7 1 0 0 1 1 1 1 CUB-like domain DUF1986 PF09342.9 001076538.1_06527001_1 - 0.0019 18.4 0.0 0.004 17.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) WD40 PF00400.30 001105459.1_06528001_3 - 4.4e-21 74.7 2.0 7.9e-05 23.2 0.0 6.3 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001105459.1_06528001_3 - 6e-11 42.4 0.0 0.036 14.2 0.0 4.6 3 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain IL8 PF00048.18 175827.2_06522001_1 - 2.3e-21 75.5 1.5 3.5e-21 75.0 1.5 1.3 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Gelsolin PF00626.20 174177.2_06526001_3 - 1e-91 300.7 0.6 1.1e-17 63.5 0.0 6.4 6 0 0 6 6 6 6 Gelsolin repeat Cadherin PF00028.15 001099705.1_06529001_1 - 1.8e-83 275.0 0.0 3.9e-17 62.3 0.0 6.4 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001099705.1_06529001_1 - 4.2e-37 125.7 0.0 3.8e-32 109.8 0.0 4.5 6 0 0 6 6 6 2 Cadherin-like Cadherin_tail PF15974.3 001099705.1_06529001_1 - 8.7e-26 90.7 2.8 1.6e-25 89.8 2.8 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 001099705.1_06529001_1 - 1.6e-23 83.1 0.1 3.7e-23 82.0 0.1 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal zf-RING_2 PF13639.4 001105458.1_06527001_2 - 1.6e-06 28.2 10.6 1.6e-06 28.2 10.6 2.7 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 001105458.1_06527001_2 - 5.5e-06 26.0 9.8 5.5e-06 26.0 9.8 2.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001105458.1_06527001_2 - 1.6e-05 24.5 9.2 1.6e-05 24.5 9.2 2.9 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001105458.1_06527001_2 - 0.00014 21.5 10.8 0.00014 21.5 10.8 2.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) bZIP_1 PF00170.19 001105458.1_06527001_2 - 0.00029 20.7 16.9 0.098 12.6 0.5 3.9 3 0 0 3 3 3 2 bZIP transcription factor zf-rbx1 PF12678.5 001105458.1_06527001_2 - 0.00088 19.4 7.6 0.004 17.3 7.6 2.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-P11 PF03854.12 001105458.1_06527001_2 - 0.0026 17.2 7.6 0.0084 15.6 7.6 1.8 1 0 0 1 1 1 1 P-11 zinc finger THOC7 PF05615.11 001105458.1_06527001_2 - 0.0045 17.1 1.8 0.0045 17.1 1.8 3.2 3 1 0 3 3 3 1 Tho complex subunit 7 zf-RING_UBOX PF13445.4 001105458.1_06527001_2 - 0.0061 16.4 7.5 0.027 14.3 7.5 2.3 1 0 0 1 1 1 1 RING-type zinc-finger DivIC PF04977.13 001105458.1_06527001_2 - 0.0091 15.6 15.4 0.8 9.4 2.6 3.5 3 0 0 3 3 3 2 Septum formation initiator CENP-Q PF13094.4 001105458.1_06527001_2 - 0.011 15.8 2.4 0.011 15.8 2.4 3.5 4 0 0 4 4 4 0 CENP-Q, a CENPA-CAD centromere complex subunit TMF_TATA_bd PF12325.6 001105458.1_06527001_2 - 0.017 15.2 1.7 0.017 15.2 1.7 2.8 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding ZapB PF06005.10 001105458.1_06527001_2 - 0.019 15.3 0.7 0.019 15.3 0.7 3.8 2 2 1 3 3 3 0 Cell division protein ZapB DUF641 PF04859.10 001105458.1_06527001_2 - 0.052 13.7 8.0 0.65 10.2 3.4 2.7 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) zf-RING_6 PF14835.4 001105458.1_06527001_2 - 0.15 11.8 5.1 0.55 10.0 5.1 1.9 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Prok-RING_4 PF14447.4 001105458.1_06527001_2 - 0.2 11.4 13.3 0.64 9.8 13.3 1.9 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 001105458.1_06527001_2 - 0.28 11.0 9.0 1.8 8.5 9.0 2.5 1 0 0 1 1 1 0 zinc-RING finger domain TMF_DNA_bd PF12329.6 001105458.1_06527001_2 - 0.29 11.0 24.3 0.082 12.8 4.2 3.8 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding PEP-utilisers_N PF05524.11 001105458.1_06527001_2 - 0.43 10.6 1.6 1 9.4 0.4 2.1 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal zf-C3HC4_4 PF15227.4 001105458.1_06527001_2 - 0.57 10.3 9.8 2.9 8.0 9.8 2.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING PRKG1_interact PF15898.3 001105458.1_06527001_2 - 0.67 10.8 24.9 0.052 14.3 4.4 3.6 3 1 0 3 3 3 0 cGMP-dependent protein kinase interacting domain XhlA PF10779.7 001105458.1_06527001_2 - 0.84 9.7 17.5 0.6 10.2 1.5 3.6 3 0 0 3 3 3 0 Haemolysin XhlA betaPIX_CC PF16523.3 001105458.1_06527001_2 - 0.85 9.3 12.3 0.12 12.1 2.4 3.0 3 0 0 3 3 3 0 betaPIX coiled coil SHE3 PF17078.3 001105458.1_06527001_2 - 1 8.9 18.6 3.6 7.1 6.2 2.8 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 TSC22 PF01166.16 001105458.1_06527001_2 - 1.2 9.3 16.1 3.2 8.0 0.5 4.5 2 1 2 4 4 4 0 TSC-22/dip/bun family Tektin PF03148.12 001105458.1_06527001_2 - 1.6 7.3 17.8 0.075 11.6 4.3 2.6 1 1 0 2 2 2 0 Tektin family FlaC_arch PF05377.9 001105458.1_06527001_2 - 2.7 8.3 12.1 9 6.6 1.2 3.7 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) CENP-F_leu_zip PF10473.7 001105458.1_06527001_2 - 3 7.8 19.5 1.3 8.9 10.8 2.6 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 NPV_P10 PF05531.10 001105458.1_06527001_2 - 3.4 8.0 7.4 12 6.3 0.2 3.2 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein zf-RING_4 PF14570.4 001105458.1_06527001_2 - 6.3 6.5 9.3 25 4.6 7.5 2.6 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain DUF972 PF06156.11 001105458.1_06527001_2 - 7 7.2 16.5 0.37 11.3 0.7 3.8 1 1 1 3 3 3 0 Protein of unknown function (DUF972) MCC-bdg_PDZ PF10506.7 001105458.1_06527001_2 - 7 6.6 7.3 3.9 7.4 0.5 3.3 3 0 0 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Prefoldin_2 PF01920.18 001105458.1_06527001_2 - 7.2 6.5 16.2 1.5 8.7 2.0 3.5 3 0 0 3 3 3 0 Prefoldin subunit Fib_alpha PF08702.8 001105458.1_06527001_2 - 8.6 6.4 13.1 13 5.8 2.0 2.9 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Fz PF01392.20 001034393.1_06525001_3 - 3e-28 98.6 2.7 7.6e-28 97.3 2.7 1.7 1 0 0 1 1 1 1 Fz domain NTR PF01759.19 001034393.1_06525001_3 - 1.2e-13 50.6 1.1 2.2e-13 49.8 1.1 1.4 1 0 0 1 1 1 1 UNC-6/NTR/C345C module HEAT PF02985.20 001034552.1_06523001_2 - 7.5e-05 22.5 0.3 2.5 8.4 0.0 4.1 4 0 0 4 4 4 2 HEAT repeat Cnd1 PF12717.5 001034552.1_06523001_2 - 0.0026 17.7 0.0 0.0051 16.7 0.0 1.5 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.4 001034552.1_06523001_2 - 0.055 13.8 0.0 15 6.1 0.0 2.8 2 1 1 3 3 3 0 HEAT-like repeat Interferon PF00143.17 001099441.1_21022001_1 - 2.1e-67 226.2 0.0 2.4e-67 226.0 0.0 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain CBF PF03914.15 001099441.1_21022001_1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 CBF/Mak21 family PGM_PMM_I PF02878.14 001045922.1_06525001_3 - 6e-18 64.7 0.0 7.9e-08 32.0 0.0 2.8 1 1 1 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.18 001045922.1_06525001_3 - 3.5e-09 36.6 0.1 1.1e-08 35.0 0.1 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.14 001045922.1_06525001_3 - 0.00038 20.5 0.2 0.0012 18.9 0.2 1.9 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III DUF969 PF06149.10 001045922.1_06525001_3 - 0.026 13.8 0.1 0.044 13.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF969) MAPEG PF01124.16 001035046.2_06522001_2 - 4.2e-24 84.8 0.5 5.9e-24 84.3 0.5 1.1 1 0 0 1 1 1 1 MAPEG family Metallophos_2 PF12850.5 001034455.2_06523001_3 - 1.6e-20 73.8 0.0 2.1e-20 73.5 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.26 001034455.2_06523001_3 - 0.00019 21.8 0.6 0.22 11.8 0.2 2.3 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase Pkinase PF00069.23 001075826.1_06523001_1 - 6.1e-33 114.2 0.3 8e-33 113.8 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001075826.1_06523001_1 - 4.9e-24 84.9 0.4 6.4e-24 84.5 0.4 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 001075826.1_06523001_1 - 0.062 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001075826.1_06523001_1 - 0.086 12.6 0.0 0.59 9.9 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family GGACT PF06094.10 001075571.1_06523001_2 - 1.7e-22 80.1 0.1 2.8e-22 79.5 0.1 1.4 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.4 001075571.1_06523001_2 - 7.8e-05 22.9 0.0 0.00014 22.1 0.0 1.5 1 0 0 1 1 1 1 AIG2-like family MMS19_C PF12460.6 001102157.2_06527001_1 - 1.5e-75 254.8 0.2 2e-75 254.4 0.2 1.1 1 0 0 1 1 1 1 RNAPII transcription regulator C-terminal HEAT_2 PF13646.4 001102157.2_06527001_1 - 0.00019 21.6 0.4 0.00036 20.7 0.4 1.4 1 0 0 1 1 1 1 HEAT repeats Dopey_N PF04118.12 001102157.2_06527001_1 - 0.059 12.4 0.3 0.15 11.1 0.3 1.5 1 1 0 1 1 1 0 Dopey, N-terminal HEAT_EZ PF13513.4 001102157.2_06527001_1 - 0.46 10.9 10.8 1.3 9.5 0.4 4.4 2 1 2 4 4 4 0 HEAT-like repeat HEAT PF02985.20 001102157.2_06527001_1 - 3.5 8.0 10.9 0.25 11.5 0.1 4.0 4 0 0 4 4 4 0 HEAT repeat MMS19_N PF14500.4 001102157.2_06527001_2 - 1.1e-86 290.5 1.0 5.5e-86 288.2 0.0 2.4 3 0 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II MMS19_C PF12460.6 001102157.2_06527001_2 - 5.9e-28 98.0 0.0 5.9e-28 98.0 0.0 2.8 3 1 0 3 3 3 1 RNAPII transcription regulator C-terminal DUF3437 PF11919.6 001102157.2_06527001_2 - 0.00034 20.4 0.5 1.8 8.5 0.0 4.6 5 0 0 5 5 5 1 Domain of unknown function (DUF3437) RTP1_C1 PF10363.7 001102157.2_06527001_2 - 0.044 13.8 1.6 4.9 7.2 0.1 4.0 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF3699 PF12480.6 001046625.1_06524001_1 - 3.6e-23 81.3 0.3 3.1e-22 78.4 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3699) NKAIN PF05640.12 001102345.1_06525001_3 - 3.6e-92 307.0 7.6 4.9e-92 306.6 7.6 1.2 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein TRP_2 PF08344.9 174476.2_06525001_2 - 8e-25 86.7 1.2 1.8e-24 85.6 1.2 1.6 1 0 0 1 1 1 1 Transient receptor ion channel II Ion_trans PF00520.29 174476.2_06525001_2 - 4.2e-17 62.0 11.1 7.8e-17 61.2 11.1 1.4 1 0 0 1 1 1 1 Ion transport protein Ank_2 PF12796.5 174476.2_06525001_2 - 1.8e-06 28.3 1.3 0.00016 22.1 0.3 2.8 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 174476.2_06525001_2 - 7.7e-06 26.2 0.1 0.064 13.7 0.0 3.0 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 174476.2_06525001_2 - 0.023 15.0 1.7 57 4.6 0.0 4.9 5 0 0 5 5 5 0 Ankyrin repeat Acetyltransf_1 PF00583.23 001075559.2_06522001_1 - 4.6e-11 42.9 0.0 6.7e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.5 001075559.2_06522001_1 - 3.9e-08 33.5 0.0 6.1e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.5 001075559.2_06522001_1 - 1.1e-07 31.8 0.0 1.6e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.5 001075559.2_06522001_1 - 0.023 14.8 0.0 0.036 14.2 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Glyco_hydro_18 PF00704.26 001015515.1_06523001_3 - 1.2e-21 77.7 0.0 1.4e-21 77.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 ANAPC15 PF15243.4 001015515.1_06523001_3 - 0.052 13.8 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 PGK PF00162.17 001034299.1_06524001_1 - 4.6e-150 499.7 0.2 5.4e-150 499.4 0.2 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase Sugar_tr PF00083.22 001081866.2_21024001_3 - 4e-152 507.1 15.9 4.7e-152 506.9 15.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001081866.2_21024001_3 - 4.4e-18 65.2 39.4 7.2e-17 61.2 30.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_2_3 PF16080.3 001081866.2_21024001_3 - 0.015 14.9 1.2 0.051 13.2 0.2 2.5 2 0 0 2 2 2 0 Bacteriophage holin family HP1 Phospholamban PF04272.12 001103319.1_06526001_2 - 1.2e-32 111.0 8.9 3.4e-32 109.6 8.9 1.8 1 0 0 1 1 1 1 Phospholamban Tetraspannin PF00335.18 001079629.2_06523001_1 - 1.5e-41 142.4 16.6 1.9e-41 142.0 16.6 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF4079 PF13301.4 001079629.2_06523001_1 - 0.026 14.6 1.1 0.026 14.6 1.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4079) DUF4604 PF15377.4 001079629.2_06523001_1 - 0.37 11.1 17.2 0.55 10.5 17.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) MARVEL PF01284.21 001079629.2_06523001_1 - 0.64 9.9 14.9 0.33 10.9 11.1 2.4 1 1 1 2 2 2 0 Membrane-associating domain DUF4131 PF13567.4 001079629.2_06523001_1 - 1.4 8.4 4.3 0.28 10.6 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF4870 PF09685.8 001079629.2_06523001_1 - 6.6 6.7 13.9 1.2 9.2 8.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4870) Peptidase_S49_N PF08496.8 001079629.2_06523001_2 - 3.3 7.6 12.2 4.4 7.2 12.2 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal SOXp PF12336.6 001105463.2_06523001_3 - 6.3e-38 129.6 4.7 6.3e-38 129.6 4.7 2.3 3 0 0 3 3 3 1 SOX transcription factor HMG_box PF00505.17 001105463.2_06523001_3 - 1.3e-27 95.9 3.0 3.3e-27 94.6 3.0 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 001105463.2_06523001_3 - 1.1e-11 45.1 1.6 2.7e-11 43.8 1.6 1.7 1 0 0 1 1 1 1 HMG-box domain Ly49 PF08391.8 001081923.1_21023001_3 - 3.3e-50 169.3 6.1 5.5e-50 168.6 6.1 1.4 1 0 0 1 1 1 1 Ly49-like protein, N-terminal region Lectin_C PF00059.19 001081923.1_21023001_3 - 4.4e-15 56.2 3.1 8.2e-15 55.3 3.1 1.5 1 0 0 1 1 1 1 Lectin C-type domain Tetraspannin PF00335.18 001081923.1_21023001_3 - 0.043 13.5 1.7 0.075 12.7 1.7 1.4 1 0 0 1 1 1 0 Tetraspanin family Amelogenin PF02948.13 001085422.1_21022001_1 - 1.6e-62 211.0 39.0 2.6e-62 210.4 39.0 1.3 1 0 0 1 1 1 1 Amelogenin Ribosomal_L10 PF00466.18 001012682.1_06523001_1 - 3.7e-22 78.2 0.0 7e-22 77.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.17 001012682.1_06523001_1 - 1.1e-20 73.8 5.0 1.1e-20 73.8 5.0 1.8 2 0 0 2 2 2 1 60s Acidic ribosomal protein Lectin_C PF00059.19 001081916.1_21022001_1 - 6e-18 65.4 0.1 8.3e-18 65.0 0.1 1.2 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 001081916.1_21022001_1 - 3.9e-09 36.0 26.0 1.1e-08 34.6 26.0 1.7 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) BRICHOS PF04089.12 001081822.1_21023001_1 - 4.9e-17 61.7 0.0 1e-16 60.7 0.0 1.5 1 0 0 1 1 1 1 BRICHOS domain RIB43A PF05914.10 001081822.1_21023001_1 - 0.017 13.8 0.0 0.022 13.4 0.0 1.1 1 0 0 1 1 1 0 RIB43A RNA_polI_A34 PF08208.9 001038067.1_06525001_1 - 0.24 11.3 34.2 0.38 10.7 34.2 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RIIa PF02197.15 001038067.1_06525001_2 - 7.1e-11 41.5 0.4 6.6e-09 35.2 0.0 2.3 2 0 0 2 2 2 2 Regulatory subunit of type II PKA R-subunit ST7 PF04184.10 001114148.1_21024001_1 - 0 1073.7 1.9 0 1073.5 1.9 1.0 1 0 0 1 1 1 1 ST7 protein TPR_6 PF13174.4 001114148.1_21024001_1 - 0.00062 20.1 0.0 0.0033 17.8 0.0 2.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.15 001114148.1_21024001_1 - 0.0051 16.7 0.2 4.8 7.4 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat Clathrin PF00637.18 001114148.1_21024001_1 - 0.06 13.1 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Region in Clathrin and VPS TPR_19 PF14559.4 001114148.1_21024001_1 - 0.15 12.5 4.9 0.41 11.1 0.5 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.26 001114148.1_21024001_1 - 1.4 8.7 3.4 1.1e+02 2.8 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.4 001114148.1_21024001_1 - 2.4 9.1 8.2 15 6.6 0.0 4.6 3 2 2 5 5 5 0 Tetratricopeptide repeat OATP PF03137.18 001046063.1_06525001_1 - 0.44 8.6 8.6 0.56 8.3 8.6 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Connexin PF00029.17 001046063.1_06525001_1 - 3.6 7.2 13.1 4.9 6.7 13.1 1.1 1 0 0 1 1 1 0 Connexin Serpin PF00079.18 001046063.1_06525001_2 - 1.7e-93 313.8 0.0 2.1e-93 313.5 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) EOS1 PF12326.6 001046063.1_06525001_2 - 0.23 11.2 1.7 0.39 10.5 1.7 1.4 1 0 0 1 1 1 0 N-glycosylation protein Connexin PF00029.17 001046063.1_06525001_2 - 2.4 7.7 13.8 4 7.0 13.8 1.3 1 0 0 1 1 1 0 Connexin CLN3 PF02487.15 001046063.1_06525001_3 - 0.085 11.8 0.3 0.11 11.4 0.3 1.1 1 0 0 1 1 1 0 CLN3 protein VKG_Carbox PF05090.12 001046063.1_06525001_3 - 2.5 6.7 6.4 3.6 6.2 6.4 1.1 1 0 0 1 1 1 0 Vitamin K-dependent gamma-carboxylase Connexin PF00029.17 001046063.1_06525001_3 - 2.9 7.5 13.7 4.3 6.9 13.7 1.2 1 0 0 1 1 1 0 Connexin Eapp_C PF10238.7 001046063.1_06525001_3 - 8.6 6.3 13.6 14 5.6 13.6 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein Adaptin_N PF01602.18 001101950.1_06526001_2 - 5.2e-67 226.4 0.1 6.3e-67 226.2 0.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.5 001101950.1_06526001_2 - 1.2e-34 119.5 0.0 4.4e-34 117.7 0.0 1.9 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.4 001101950.1_06526001_2 - 4.8e-07 29.9 0.0 0.0074 16.5 0.0 4.0 3 1 2 5 5 5 3 HEAT repeats HEAT PF02985.20 001101950.1_06526001_2 - 1.6e-06 27.7 8.2 0.61 10.3 0.1 6.0 7 0 0 7 7 7 3 HEAT repeat RTP1_C1 PF10363.7 001101950.1_06526001_2 - 0.13 12.3 0.1 3.3 7.8 0.0 3.1 2 2 2 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 B2-adapt-app_C PF09066.8 001101950.1_06526001_3 - 5.6e-28 97.1 0.4 8.4e-28 96.6 0.4 1.3 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain Adaptin_N PF01602.18 001101950.1_06526001_3 - 5.2e-11 41.7 0.0 7.5e-11 41.1 0.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region IRK PF01007.18 001024690.2_06524001_1 - 3.1e-157 522.6 0.1 3.7e-157 522.3 0.1 1.0 1 0 0 1 1 1 1 Inward rectifier potassium channel IRK_N PF08466.8 001024690.2_06524001_1 - 1e-24 86.3 1.0 2.3e-24 85.1 1.0 1.6 1 0 0 1 1 1 1 Inward rectifier potassium channel N-terminal Ion_trans_2 PF07885.14 001024690.2_06524001_1 - 0.0051 16.6 2.5 0.013 15.3 2.5 1.7 1 1 0 1 1 1 1 Ion channel Fibrinogen_C PF00147.16 001101063.1_06523001_1 - 0.0008 19.1 0.4 0.0014 18.4 0.4 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain F-box PF00646.31 001082617.2_06529001_3 - 6.6e-09 35.3 1.5 1.7e-08 34.0 1.5 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.5 001082617.2_06529001_3 - 2.7e-08 33.5 0.7 1.1e-07 31.5 0.7 2.1 1 0 0 1 1 1 1 F-box-like V-set_2 PF15910.3 001100179.1_21022001_1 - 7e-15 55.0 1.1 1e-14 54.4 1.1 1.2 1 0 0 1 1 1 1 ICOS V-set domain V-set PF07686.15 001100179.1_21022001_1 - 1e-05 25.5 0.2 1.5e-05 24.9 0.2 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ras PF00071.20 001098109.1_06529001_3 - 8.6e-41 139.1 0.3 1.3e-40 138.5 0.3 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001098109.1_06529001_3 - 2.1e-22 79.5 0.1 7.4e-22 77.7 0.1 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001098109.1_06529001_3 - 5.9e-12 45.3 0.0 8.7e-12 44.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DnaJ PF00226.29 001098109.1_06529001_3 - 3.5e-11 42.9 0.0 6.7e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain MMR_HSR1 PF01926.21 001098109.1_06529001_3 - 0.0014 18.6 0.0 0.0022 17.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001098109.1_06529001_3 - 0.007 15.6 0.1 0.0094 15.2 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region TMEM51 PF15345.4 001099384.1_06525001_2 - 0.18 11.5 1.7 0.25 11.0 1.7 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 OAD_gamma PF04277.11 001099384.1_06525001_2 - 1.8 9.1 7.4 3.7 8.1 7.4 1.6 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Histone PF00125.22 001099384.1_06525001_3 - 3.6e-24 85.5 1.1 3.6e-24 85.5 1.1 2.2 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 001099384.1_06525001_3 - 1.7e-05 24.8 0.0 3.8e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone 7tm_1 PF00001.19 001099384.1_06525001_3 - 0.0037 16.4 2.5 0.0089 15.2 2.5 1.7 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Syja_N PF02383.16 001076014.1_06527001_1 - 2.6e-71 240.3 0.0 4.7e-71 239.5 0.0 1.4 1 0 0 1 1 1 1 SacI homology domain DUF1892 PF08987.8 001076014.1_06527001_1 - 0.13 12.3 0.1 1.5 8.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1892) SCAN PF02023.15 001076159.1_06523001_3 - 1.2e-39 133.9 3.4 1.7e-39 133.4 3.4 1.2 1 0 0 1 1 1 1 SCAN domain ANAPC4_WD40 PF12894.5 001046086.2_06523001_2 - 0.021 15.0 0.0 0.19 11.9 0.0 2.4 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain LVIVD PF08309.9 001046086.2_06523001_2 - 0.032 13.4 0.0 0.064 12.5 0.0 1.4 1 0 0 1 1 1 0 LVIVD repeat PQQ_2 PF13360.4 001046086.2_06523001_2 - 0.072 12.5 0.1 13 5.2 0.0 2.2 1 1 0 2 2 2 0 PQQ-like domain PQQ_3 PF13570.4 001046086.2_06523001_2 - 0.083 13.3 0.8 1.5 9.3 0.2 2.7 2 0 0 2 2 2 0 PQQ-like domain WD40 PF00400.30 001046086.2_06523001_2 - 3.9 8.4 5.4 34 5.4 0.0 4.4 6 0 0 6 6 6 0 WD domain, G-beta repeat 7tm_1 PF00001.19 174231.1_06525001_2 - 9.9e-70 234.7 15.1 1.3e-69 234.3 15.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 174231.1_06525001_2 - 2.3e-13 50.0 17.4 3.2e-13 49.5 17.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 174231.1_06525001_2 - 3e-07 30.3 9.4 3e-07 30.3 9.4 2.0 2 0 0 2 2 2 1 Olfactory receptor FAM216B PF15107.4 001076315.1_06523001_1 - 2.2e-54 181.9 0.8 3.9e-54 181.1 0.8 1.4 1 0 0 1 1 1 1 FAM216B protein family zf-Tim10_DDP PF02953.13 001046254.1_06523001_1 - 2.7e-15 55.7 3.9 4.4e-15 54.9 3.9 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger A_thal_3526 PF09713.8 001046254.1_06523001_1 - 0.08 13.1 4.2 1.9 8.7 0.0 2.7 3 0 0 3 3 3 0 Plant protein 1589 of unknown function (A_thal_3526) DUF2116 PF09889.7 001046254.1_06523001_1 - 1.3 8.9 4.5 0.24 11.3 0.8 1.7 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Rho_GDI PF02115.15 176650.3_06524001_3 - 1e-80 269.9 0.2 1.3e-80 269.6 0.2 1.1 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor DUF1687 PF07955.9 176650.3_06524001_3 - 0.17 12.3 0.2 0.27 11.6 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1687) LRR_8 PF13855.4 173910.1_06525001_2 - 1.1e-30 105.1 27.9 5.7e-11 41.9 6.0 6.2 4 2 3 7 7 7 7 Leucine rich repeat LRR_4 PF12799.5 173910.1_06525001_2 - 4.9e-13 48.9 30.9 0.00057 20.1 2.8 7.5 3 2 5 8 8 8 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 173910.1_06525001_2 - 9.1e-07 28.3 13.5 1.2 9.2 0.2 7.5 8 0 0 8 8 8 3 Leucine Rich repeat LRRNT PF01462.16 173910.1_06525001_2 - 1.8e-06 27.3 2.7 1.8e-06 27.3 2.7 2.5 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 173910.1_06525001_2 - 2.4e-05 23.8 11.5 0.055 12.8 2.5 3.4 1 1 2 3 3 3 3 Leucine-rich repeat Homeobox PF00046.27 001034676.2_06525001_3 - 2.2e-20 72.1 5.2 4.2e-20 71.2 5.2 1.5 1 0 0 1 1 1 1 Homeobox domain Arm PF00514.21 001098966.1_06525001_2 - 1.3e-18 66.2 20.3 5e-06 26.2 0.1 6.5 7 0 0 7 7 7 4 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.7 001098966.1_06525001_2 - 7.3e-05 22.6 2.2 0.34 10.9 0.1 4.5 2 1 1 4 4 4 2 Spinocerebellar ataxia type 10 protein domain DUF3361 PF11841.6 001098966.1_06525001_2 - 0.007 16.2 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) Neurochondrin PF05536.9 001098966.1_06525001_2 - 0.034 12.4 2.8 0.38 8.9 0.2 2.9 2 2 1 3 3 3 0 Neurochondrin E3_UbLigase_R4 PF13764.4 001098966.1_06525001_2 - 0.067 11.2 4.3 0.54 8.2 0.9 2.7 2 1 1 3 3 3 0 E3 ubiquitin-protein ligase UBR4 ATP-synt_8 PF00895.18 001077136.1_06528001_1 - 0.47 10.8 5.8 1.7 9.0 5.8 2.0 1 0 0 1 1 1 0 ATP synthase protein 8 OAD_gamma PF04277.11 001077136.1_06528001_1 - 0.71 10.4 9.8 2.4 8.7 9.8 1.9 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain BCIP PF13862.4 001077136.1_06528001_1 - 1.1 8.8 10.2 1.8 8.2 10.2 1.2 1 0 0 1 1 1 0 p21-C-terminal region-binding protein ETRAMP PF09716.8 001077136.1_06528001_1 - 4.2 7.4 21.3 12 5.9 21.3 1.8 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF4604 PF15377.4 001077136.1_06528001_2 - 1.3 9.3 18.3 2 8.7 18.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) PI-PLC-X PF00388.17 001046489.2_06527001_3 - 7e-66 220.2 0.0 1.2e-65 219.3 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.17 001046489.2_06527001_3 - 4.3e-43 146.2 0.1 9.3e-43 145.1 0.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.9 001046489.2_06527001_3 - 1.5e-35 121.4 0.1 4.6e-35 119.8 0.1 1.9 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_10 PF14788.4 001046489.2_06527001_3 - 8.7e-24 83.0 1.5 1.1e-23 82.7 0.3 1.8 2 0 0 2 2 2 1 EF hand C2 PF00168.28 001046489.2_06527001_3 - 4.9e-15 55.6 0.0 1.1e-14 54.4 0.0 1.6 1 0 0 1 1 1 1 C2 domain EF-hand_7 PF13499.4 001046489.2_06527001_3 - 5.1e-09 36.3 4.8 7.5e-06 26.2 0.3 2.7 1 1 2 3 3 3 3 EF-hand domain pair PH PF00169.27 001046489.2_06527001_3 - 1.7e-08 34.7 0.0 3.6e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 PH domain EF-hand_1 PF00036.30 001046489.2_06527001_3 - 1.4e-07 30.4 0.1 0.023 14.1 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 001046489.2_06527001_3 - 1.7e-06 27.3 2.2 0.37 10.7 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.4 001046489.2_06527001_3 - 7.4e-05 22.0 0.4 0.04 13.3 0.1 2.5 2 0 0 2 2 2 2 EF hand PH_12 PF16457.3 001046489.2_06527001_3 - 0.0015 18.9 0.4 0.011 16.1 0.4 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain Wap1 PF16997.3 001046489.2_06527001_3 - 0.042 12.9 0.0 0.065 12.2 0.0 1.2 1 0 0 1 1 1 0 Wap1 domain GDPD PF03009.15 001046489.2_06527001_3 - 0.043 13.4 0.0 0.076 12.6 0.0 1.3 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family Pkinase_Tyr PF07714.15 001105328.1_06527001_1 - 1.1e-36 126.4 0.0 1.4e-36 126.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001105328.1_06527001_1 - 1.4e-35 122.8 0.0 2.1e-35 122.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain TGF_beta_GS PF08515.10 001105328.1_06527001_1 - 2.4e-15 55.5 0.9 5.8e-15 54.3 0.9 1.7 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Activin_recp PF01064.21 001105328.1_06527001_1 - 8.6e-13 49.0 11.3 2.4e-12 47.6 11.3 1.9 1 0 0 1 1 1 1 Activin types I and II receptor domain FTA2 PF13095.4 001105328.1_06527001_1 - 0.026 14.0 0.0 0.043 13.3 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 MCLC PF05934.9 001075784.1_06525001_3 - 0 1069.8 0.0 0 1069.5 0.0 1.0 1 0 0 1 1 1 1 Mid-1-related chloride channel (MCLC) Presenilin PF01080.15 174721.2_06524001_3 - 6.5e-166 551.9 9.6 6.5e-166 551.9 9.6 2.0 2 0 0 2 2 2 1 Presenilin VIT1 PF01988.17 174721.2_06524001_3 - 0.037 13.8 0.3 6.8 6.3 0.0 2.3 2 0 0 2 2 2 0 VIT family Rifin_STEVOR PF02009.14 174721.2_06524001_3 - 0.18 11.6 0.2 0.31 10.7 0.2 1.4 1 0 0 1 1 1 0 Rifin/stevor family LRRC37AB_C PF14914.4 174721.2_06524001_3 - 0.55 10.0 5.1 2.9 7.6 0.1 2.6 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain LAP1C PF05609.10 174721.2_06524001_3 - 0.57 9.1 5.1 0.16 10.9 0.1 2.1 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) ECSCR PF15820.3 174721.2_06524001_3 - 8.3 6.2 8.8 0.5 10.1 1.1 2.7 1 1 1 2 2 2 0 Endothelial cell-specific chemotaxis regulator MRP-S32 PF10210.7 001037622.2_06522001_2 - 1.3e-41 141.0 1.6 1.7e-41 140.6 1.6 1.2 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S32 DUF4581 PF15167.4 001101246.1_06529001_1 - 5.7e-80 265.7 0.6 8.8e-80 265.1 0.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4581) COesterase PF00135.26 001076220.1_06525001_3 - 8.2e-171 569.3 0.0 9.7e-171 569.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family AChE_tetra PF08674.8 001076220.1_06525001_3 - 2.5e-20 71.8 9.4 4.5e-20 70.9 9.4 1.5 1 0 0 1 1 1 1 Acetylcholinesterase tetramerisation domain Abhydrolase_3 PF07859.11 001076220.1_06525001_3 - 1e-05 25.4 0.4 2.9e-05 23.9 0.4 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold SLX9 PF15341.4 001046108.2_06522001_2 - 9.3e-24 84.1 3.0 1.4e-23 83.6 3.0 1.3 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 LANC_like PF05147.11 001076227.1_06529001_2 - 1.1e-103 346.4 0.2 1.5e-103 345.9 0.2 1.2 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein Glyco_hydro_127 PF07944.10 001076227.1_06529001_2 - 0.013 13.9 0.2 1.7 6.9 0.1 2.1 2 0 0 2 2 2 0 Beta-L-arabinofuranosidase, GH127 C5-epim_C PF06662.11 001076227.1_06529001_2 - 0.061 12.7 5.3 9.4 5.6 1.9 3.2 2 1 1 3 3 3 0 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_88 PF07470.11 001076227.1_06529001_2 - 0.18 10.7 0.2 3.1 6.6 0.1 2.1 2 0 0 2 2 2 0 Glycosyl Hydrolase Family 88 Myb_DNA-bind_5 PF13873.4 001046078.2_06526001_3 - 9.7e-23 79.9 6.2 2.5e-22 78.6 6.2 1.7 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-binding PF00249.29 001046078.2_06526001_3 - 0.095 12.7 0.1 0.26 11.3 0.1 1.8 1 1 0 1 1 1 0 Myb-like DNA-binding domain Hormone_1 PF00103.18 001081896.1_21022001_1 - 3.5e-80 268.7 0.9 4.1e-80 268.4 0.9 1.0 1 0 0 1 1 1 1 Somatotropin hormone family KIAA1430 PF13879.4 001081896.1_21022001_1 - 0.043 14.4 0.4 0.73 10.5 0.1 2.2 2 0 0 2 2 2 0 KIAA1430 homologue Ank_4 PF13637.4 001075192.1_06525001_3 - 1.4e-16 60.4 1.8 7e-11 42.3 0.4 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 001075192.1_06525001_3 - 2e-16 60.2 2.0 1.4e-14 54.3 0.7 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001075192.1_06525001_3 - 1.3e-15 57.1 1.3 3.2e-10 40.0 0.2 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.28 001075192.1_06525001_3 - 4.4e-12 45.7 2.0 2.6e-09 37.0 0.2 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.4 001075192.1_06525001_3 - 1.7e-09 37.0 0.4 4.9e-05 23.3 0.1 3.6 3 0 0 3 3 3 2 Ankyrin repeat SAM_1 PF00536.28 001075192.1_06525001_3 - 6.9e-09 35.9 0.0 1.5e-08 34.8 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 001075192.1_06525001_3 - 2.1e-05 24.4 0.1 4e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF5024 PF16427.3 001075192.1_06525001_3 - 0.78 10.0 5.8 0.83 9.9 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5024) Ferritin PF00210.22 001100413.1_21022001_2 - 6.9e-39 132.9 6.0 8.7e-39 132.6 6.0 1.1 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.15 001100413.1_21022001_2 - 0.0097 16.2 0.6 0.015 15.6 0.6 1.3 1 0 0 1 1 1 1 Rubrerythrin DUF3456 PF11938.6 001075267.2_06522001_3 - 6.1e-42 143.7 0.6 7.8e-42 143.3 0.6 1.1 1 0 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP SapB_2 PF03489.15 001075267.2_06522001_3 - 0.011 15.7 0.1 0.051 13.6 0.0 2.1 2 0 0 2 2 2 0 Saposin-like type B, region 2 POX PF07526.9 001075267.2_06522001_3 - 0.12 12.8 0.0 0.18 12.3 0.0 1.3 1 0 0 1 1 1 0 Associated with HOX Xlink PF00193.15 001082504.1_21023001_1 - 1.4e-62 208.0 0.1 9e-34 115.6 0.0 2.3 2 0 0 2 2 2 2 Extracellular link domain V-set PF07686.15 001082504.1_21023001_1 - 3e-10 40.1 0.0 5.9e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001082504.1_21023001_1 - 0.00015 22.2 0.0 0.00037 20.9 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001082504.1_21023001_1 - 0.0019 18.1 0.0 0.0042 17.0 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin I-set domain Chordopox_A33R PF05966.10 001082504.1_21023001_1 - 0.0034 16.6 0.1 0.31 10.2 0.0 2.2 2 0 0 2 2 2 1 Chordopoxvirus A33R protein Ig_2 PF13895.4 001082504.1_21023001_1 - 0.0045 17.2 0.0 0.064 13.5 0.0 2.2 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001082504.1_21023001_1 - 0.017 15.1 0.0 0.049 13.7 0.0 1.8 1 1 0 1 1 1 0 Immunoglobulin domain Lectin_C PF00059.19 001082504.1_21023001_1 - 0.15 12.6 0.3 17 6.1 0.0 2.4 2 0 0 2 2 2 0 Lectin C-type domain IL8 PF00048.18 174263.2_06521001_3 - 3e-20 72.0 0.5 4.3e-20 71.5 0.5 1.2 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Connexin PF00029.17 001037490.1_06522001_1 - 1.5 8.4 5.9 1.8 8.2 5.9 1.2 1 0 0 1 1 1 0 Connexin zf-C2HC_2 PF13913.4 001037490.1_06522001_3 - 2e-21 75.3 3.9 2.7e-11 42.9 0.8 2.4 2 0 0 2 2 2 2 zinc-finger of a C2HC-type zf-C2H2 PF00096.24 001037490.1_06522001_3 - 0.0019 18.4 0.6 0.22 11.9 0.0 2.6 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001037490.1_06522001_3 - 0.0023 18.5 2.2 0.36 11.6 0.3 3.1 3 0 0 3 3 3 1 C2H2-type zinc finger Sgf11 PF08209.9 001037490.1_06522001_3 - 0.0066 15.8 0.5 0.86 9.1 0.0 2.5 2 0 0 2 2 2 2 Sgf11 (transcriptional regulation protein) EOS1 PF12326.6 001037490.1_06522001_3 - 0.23 11.3 0.8 0.21 11.3 0.8 1.1 1 0 0 1 1 1 0 N-glycosylation protein c-SKI_SMAD_bind PF08782.8 001037490.1_06522001_3 - 1.5 9.0 10.2 1.5 8.9 6.1 2.5 2 1 0 2 2 2 0 c-SKI Smad4 binding domain NinG PF05766.10 001037490.1_06522001_3 - 8.1 6.2 26.4 1.8 8.4 23.1 1.5 2 0 0 2 2 2 0 Bacteriophage Lambda NinG protein 7tm_1 PF00001.19 001081919.1_21023001_1 - 1.8e-68 230.6 0.1 2.2e-68 230.3 0.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001081919.1_21023001_1 - 1.2e-08 34.9 9.1 9.9e-08 31.9 2.8 2.2 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001081919.1_21023001_1 - 8.9e-08 31.7 13.6 6e-05 22.4 4.4 2.3 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx DUF996 PF06195.11 001081919.1_21023001_1 - 0.0072 16.5 5.2 3.1 8.0 0.1 3.3 3 0 0 3 3 3 3 Protein of unknown function (DUF996) Defensin_propep PF00879.16 001166084.1_21021001_1 - 6.5e-23 80.7 1.7 8.7e-23 80.3 1.7 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_beta PF00711.17 001166084.1_21021001_1 - 3.9 7.5 12.2 6 6.9 12.2 1.3 1 0 0 1 1 1 0 Beta defensin pKID PF02173.15 001301315.1_21024001_1 - 3.3e-21 74.3 2.5 6.5e-21 73.4 2.5 1.5 1 0 0 1 1 1 1 pKID domain bZIP_1 PF00170.19 001301315.1_21024001_1 - 1.2e-18 66.8 12.6 2.3e-18 65.9 12.6 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 001301315.1_21024001_1 - 3.2e-07 30.2 13.4 8.1e-07 28.9 13.4 1.6 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 001301315.1_21024001_1 - 0.011 16.1 5.7 0.026 14.9 5.7 1.6 1 0 0 1 1 1 0 bZIP Maf transcription factor ASD2 PF08687.9 001301315.1_21024001_1 - 0.43 10.0 4.6 0.055 12.9 0.4 1.6 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 V1R PF03402.12 001166864.1_21023001_1 - 6.7e-22 78.2 18.9 1.2e-21 77.5 18.9 1.3 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166864.1_21023001_1 - 7.9e-06 25.1 24.9 1e-05 24.7 24.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Sof1 PF04158.12 001309279.1_21024001_3 - 5.3e-34 116.2 12.6 7.9e-34 115.7 12.6 1.3 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.30 001309279.1_21024001_3 - 5.3e-22 77.6 10.8 0.00025 21.7 0.0 6.3 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001309279.1_21024001_3 - 3.6e-07 30.2 0.0 0.0088 16.2 0.0 4.2 3 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 001309279.1_21024001_3 - 9.4e-07 28.8 0.3 0.00012 21.9 0.0 3.1 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A LRR_8 PF13855.4 001257171.1_21025001_1 - 3.1e-23 81.2 14.8 1.2e-13 50.4 2.6 3.1 1 1 2 3 3 3 3 Leucine rich repeat LRR_5 PF13306.4 001257171.1_21025001_1 - 8e-06 25.7 0.3 1.7e-05 24.6 0.0 1.7 2 0 0 2 2 2 1 Leucine rich repeats (6 copies) LRR_4 PF12799.5 001257171.1_21025001_1 - 1.4e-05 25.2 10.2 0.02 15.2 0.1 3.3 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) fn3 PF00041.19 001257171.1_21025001_1 - 0.038 14.2 0.1 0.085 13.1 0.1 1.5 1 0 0 1 1 1 0 Fibronectin type III domain LRR_9 PF14580.4 001257171.1_21025001_1 - 0.045 13.1 0.1 0.19 11.1 0.0 1.8 1 1 1 2 2 2 0 Leucine-rich repeat CD34_antigen PF06365.10 001257171.1_21025001_1 - 0.15 11.5 0.1 0.28 10.6 0.1 1.4 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF4552 PF15089.4 001257171.1_21025001_1 - 0.18 10.7 0.6 0.28 10.1 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4552) LRR_1 PF00560.31 001257171.1_21025001_1 - 4.7 7.9 5.9 36 5.2 0.1 4.5 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.4 001257171.1_21025001_1 - 9.8 6.4 10.0 63 3.9 0.3 4.1 4 0 0 4 4 4 0 Leucine Rich repeat Tmemb_185A PF10269.7 001242321.1_21023001_1 - 3.7e-60 203.6 27.5 5.5e-60 203.0 27.5 1.3 1 0 0 1 1 1 1 Transmembrane Fragile-X-F protein Fucokinase PF07959.10 001204808.1_21024001_1 - 8.9e-146 485.9 0.1 1.1e-145 485.6 0.1 1.1 1 0 0 1 1 1 1 L-fucokinase UPF0715 PF17094.3 001204808.1_21024001_1 - 0.05 14.0 0.2 0.17 12.3 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0715) Hexapep PF00132.22 001204808.1_21024001_1 - 0.054 13.1 0.3 0.054 13.1 0.3 2.8 3 1 0 3 3 3 0 Bacterial transferase hexapeptide (six repeats) Kelch_1 PF01344.23 001191196.3_06528001_3 - 1.8e-76 251.4 20.5 4.2e-14 51.7 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 001191196.3_06528001_3 - 1.2e-45 152.2 6.9 6.3e-10 38.8 0.0 6.5 1 1 5 6 6 6 6 Kelch motif BTB PF00651.29 001191196.3_06528001_3 - 6.1e-32 110.0 0.0 1e-31 109.3 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.13 001191196.3_06528001_3 - 2.6e-31 107.6 0.3 5.7e-31 106.5 0.3 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_2 PF07646.13 001191196.3_06528001_3 - 4.6e-24 83.3 8.4 4.7e-06 26.2 0.1 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.4 001191196.3_06528001_3 - 7.4e-24 83.4 4.1 0.00012 22.1 0.0 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_4 PF13418.4 001191196.3_06528001_3 - 1.6e-23 82.3 1.0 0.00027 20.7 0.0 6.2 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.4 001191196.3_06528001_3 - 5e-07 29.4 10.6 0.001 18.9 0.1 5.9 6 0 0 6 6 6 2 Kelch motif DUF3342 PF11822.6 001191196.3_06528001_3 - 0.0012 18.8 0.0 0.0032 17.5 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Ank_2 PF12796.5 001204105.1_21029001_2 - 1.3e-149 487.1 37.3 4.8e-19 68.6 0.8 12.3 3 3 9 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001204105.1_21029001_2 - 1.2e-119 389.1 17.5 9.1e-10 38.7 0.1 16.1 8 3 7 17 17 17 16 Ankyrin repeats (many copies) Ank PF00023.28 001204105.1_21029001_2 - 2.3e-111 359.7 51.6 5e-08 32.9 0.0 24.6 24 0 0 24 24 24 23 Ankyrin repeat Ank_3 PF13606.4 001204105.1_21029001_2 - 9.5e-103 323.5 29.3 6.5e-05 22.9 0.0 25.5 25 0 0 25 25 25 23 Ankyrin repeat Ank_5 PF13857.4 001204105.1_21029001_2 - 1.8e-98 320.7 47.9 5.4e-08 32.9 0.0 21.1 6 4 14 21 21 21 20 Ankyrin repeats (many copies) KH_1 PF00013.27 001204105.1_21029001_2 - 1e-14 54.0 0.6 2.9e-14 52.5 0.6 1.9 1 0 0 1 1 1 1 KH domain Filament PF00038.19 001346204.2_21025001_1 - 1.7e-111 372.6 38.3 2e-111 372.4 38.3 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001346204.2_21025001_1 - 4.5e-36 124.3 65.8 1e-34 119.9 33.7 2.7 2 1 0 2 2 2 2 Keratin type II head TPR_MLP1_2 PF07926.10 001346204.2_21025001_1 - 0.00038 20.4 2.7 0.00038 20.4 2.7 3.8 3 1 1 4 4 4 3 TPR/MLP1/MLP2-like protein ATG16 PF08614.9 001346204.2_21025001_1 - 0.0006 19.9 31.8 0.033 14.2 9.4 2.4 2 0 0 2 2 2 2 Autophagy protein 16 (ATG16) IncA PF04156.12 001346204.2_21025001_1 - 0.0064 16.2 36.1 0.045 13.4 2.5 3.3 1 1 1 3 3 3 2 IncA protein Spc7 PF08317.9 001346204.2_21025001_1 - 0.007 15.2 36.0 0.13 11.0 18.3 2.7 1 1 1 2 2 2 2 Spc7 kinetochore protein DUF812 PF05667.9 001346204.2_21025001_1 - 0.0088 14.9 34.3 0.2 10.4 16.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF812) Baculo_PEP_C PF04513.10 001346204.2_21025001_1 - 0.0095 15.8 5.3 0.0095 15.8 5.3 4.0 2 1 1 3 3 3 1 Baculovirus polyhedron envelope protein, PEP, C terminus Alanine_zipper PF11839.6 001346204.2_21025001_1 - 0.016 15.3 5.2 0.016 15.3 5.2 2.7 2 1 1 3 3 2 0 Alanine-zipper, major outer membrane lipoprotein Golgin_A5 PF09787.7 001346204.2_21025001_1 - 0.017 14.5 28.7 0.16 11.3 6.4 2.5 1 1 2 3 3 3 0 Golgin subfamily A member 5 Reo_sigmaC PF04582.10 001346204.2_21025001_1 - 0.029 13.7 12.5 0.57 9.4 2.2 2.8 1 1 2 3 3 3 0 Reovirus sigma C capsid protein DUF1664 PF07889.10 001346204.2_21025001_1 - 0.029 14.2 21.9 0.045 13.6 4.6 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.7 001346204.2_21025001_1 - 0.093 12.6 33.5 0.25 11.2 7.9 3.5 1 1 4 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 JIP_LZII PF16471.3 001346204.2_21025001_1 - 0.16 12.0 20.7 0.9 9.6 0.3 5.2 4 1 2 6 6 6 0 JNK-interacting protein leucine zipper II LPP PF04728.11 001346204.2_21025001_1 - 0.28 11.5 16.3 2.8 8.3 1.3 5.2 4 1 1 5 5 5 0 Lipoprotein leucine-zipper Jnk-SapK_ap_N PF09744.7 001346204.2_21025001_1 - 0.43 10.6 33.6 0.016 15.3 5.0 3.8 2 1 2 4 4 4 0 JNK_SAPK-associated protein-1 Rootletin PF15035.4 001346204.2_21025001_1 - 0.73 9.7 27.4 0.17 11.8 6.8 2.5 2 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion ADIP PF11559.6 001346204.2_21025001_1 - 0.75 9.7 33.6 0.12 12.4 9.8 3.8 2 2 2 4 4 4 0 Afadin- and alpha -actinin-Binding Fib_alpha PF08702.8 001346204.2_21025001_1 - 0.86 9.6 27.9 0.034 14.2 2.0 3.6 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.9 001346204.2_21025001_1 - 1 9.7 13.7 1.5 9.1 0.8 5.1 5 0 0 5 5 5 0 Flagella accessory protein C (FlaC) TSC22 PF01166.16 001346204.2_21025001_1 - 1.5 9.1 16.5 7.9 6.7 0.5 4.5 3 1 2 5 5 5 0 TSC-22/dip/bun family DUF342 PF03961.11 001346204.2_21025001_1 - 1.8 7.0 23.4 0.97 7.8 11.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF342) YscO-like PF16789.3 001346204.2_21025001_1 - 1.8 8.4 22.9 0.089 12.7 10.9 2.5 1 1 0 2 2 2 0 YscO-like protein CHDCT2 PF08074.9 001346204.2_21025001_1 - 2.5 8.1 16.5 0.022 14.8 2.4 2.8 1 1 0 2 2 2 0 CHDCT2 (NUC038) domain FPP PF05911.9 001346204.2_21025001_1 - 2.5 6.1 31.5 1.4 7.0 7.8 2.1 1 1 0 2 2 2 0 Filament-like plant protein, long coiled-coil Ribosomal_S30AE PF02482.17 001346204.2_21025001_1 - 4.7 7.9 9.1 0.12 13.0 1.1 2.4 3 1 0 3 3 2 0 Sigma 54 modulation protein / S30EA ribosomal protein CALCOCO1 PF07888.9 001346204.2_21025001_1 - 6.4 5.1 33.1 2.5 6.4 16.2 2.1 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like TMF_TATA_bd PF12325.6 001346204.2_21025001_1 - 10 6.3 29.5 5.4 7.1 9.0 3.8 1 1 3 4 4 4 0 TATA element modulatory factor 1 TATA binding UCH PF00443.27 001205837.1_06525001_3 - 2.4e-54 184.4 0.2 4.1e-54 183.6 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.17 001205837.1_06525001_3 - 2.7e-19 69.1 8.1 2.7e-19 69.1 8.1 3.3 5 0 0 5 5 5 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.4 001205837.1_06525001_3 - 5.3e-17 62.3 0.3 2.3e-12 47.0 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase RAG2_PHD PF13341.4 001205837.1_06525001_3 - 0.025 14.5 2.4 3.1 7.8 0.1 3.0 2 0 0 2 2 2 0 RAG2 PHD domain ArfGap PF01412.16 001205837.1_06525001_3 - 0.16 11.9 3.2 1.4 8.9 2.5 2.5 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf SCAPER_N PF16501.3 001308959.1_21029001_2 - 5.1e-44 148.1 0.2 5.1e-44 148.1 0.2 2.7 2 0 0 2 2 2 1 S phase cyclin A-associated protein in the endoplasmic reticulum zf-met PF12874.5 001308959.1_21029001_2 - 5.3e-05 23.3 1.2 0.00018 21.7 1.2 2.0 1 0 0 1 1 1 1 Zinc-finger of C2H2 type Thyroglobulin_1 PF00086.16 001308603.1_21025001_3 - 1.4e-18 66.2 2.5 3.7e-18 64.8 2.5 1.8 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat IGFBP PF00219.16 001308603.1_21025001_3 - 2e-10 41.0 22.4 2e-10 41.0 22.4 2.1 2 0 0 2 2 2 1 Insulin-like growth factor binding protein Atrophin-1 PF03154.13 001308603.1_21025001_3 - 0.14 10.3 12.6 0.26 9.4 12.6 1.4 1 0 0 1 1 1 0 Atrophin-1 family Basic PF01586.14 001317250.1_21022001_2 - 5.7e-25 88.2 0.0 1.1e-24 87.3 0.0 1.5 1 0 0 1 1 1 1 Myogenic Basic domain HLH PF00010.24 001317250.1_21022001_2 - 2.1e-12 46.7 5.4 3.7e-12 45.9 5.4 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF3080 PF11279.6 001317250.1_21022001_2 - 0.0056 15.8 0.2 0.0077 15.3 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3080) Defensin_propep PF00879.16 001166078.1_21021001_1 - 2.2e-18 66.2 1.3 3.3e-18 65.6 1.3 1.3 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166078.1_21021001_1 - 0.00011 22.5 16.7 0.00017 21.9 16.7 1.3 1 0 0 1 1 1 1 Mammalian defensin RRM_1 PF00076.20 001171746.1_21029001_3 - 1.7e-29 101.3 0.6 1.8e-07 30.7 0.0 5.3 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_NTP_bind PF07717.14 001206134.1_06529001_2 - 4.7e-18 65.2 0.0 2.1e-16 59.9 0.0 2.7 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.21 001206134.1_06529001_2 - 1.8e-16 60.2 0.1 1.8e-16 60.2 0.1 2.9 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.29 001206134.1_06529001_2 - 6.5e-15 55.3 0.0 2.7e-14 53.3 0.0 2.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.27 001206134.1_06529001_2 - 1.4e-10 41.1 0.0 3.2e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.4 001206134.1_06529001_2 - 9.6e-05 22.5 1.3 0.00023 21.3 0.2 2.2 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.18 001206134.1_06529001_2 - 0.027 13.4 0.0 0.05 12.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase PF06745.11 001206134.1_06529001_2 - 0.09 12.0 0.0 0.28 10.4 0.0 1.8 1 0 0 1 1 1 0 KaiC AAA_29 PF13555.4 001206134.1_06529001_2 - 0.17 11.5 0.0 0.51 10.0 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.25 001206134.1_06529001_2 - 1.2 9.5 0.0 1.2 9.5 0.0 2.7 3 0 0 3 3 3 0 ABC transporter C1q PF00386.19 001242530.1_21024001_3 - 8.6e-38 129.3 0.0 1.3e-37 128.7 0.0 1.3 1 0 0 1 1 1 1 C1q domain Collagen PF01391.16 001242530.1_21024001_3 - 1.1e-16 60.2 53.7 2.8e-09 36.5 27.2 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) NR_Repeat PF14046.4 001163859.1_21023001_1 - 4.9e-114 372.2 24.6 7.8e-30 102.6 1.6 4.6 4 0 0 4 4 4 4 Nuclear receptor repeat Hormone_recep PF00104.28 001163859.1_21023001_1 - 1.5e-16 60.5 0.0 1.4e-15 57.3 0.0 2.0 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Myelin-PO_C PF10570.7 001163859.1_21023001_1 - 0.063 13.6 0.0 1.1e+02 3.2 0.0 3.9 4 0 0 4 4 4 0 Myelin-PO cytoplasmic C-term p65 binding region GBP PF02263.17 001309252.1_21026001_2 - 3.4e-115 383.6 1.9 1.9e-114 381.2 0.0 2.3 2 0 0 2 2 2 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.12 001309252.1_21026001_2 - 9.4e-112 373.1 25.1 1.2e-111 372.8 25.1 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain MMR_HSR1 PF01926.21 001309252.1_21026001_2 - 0.00048 20.1 0.0 0.0015 18.5 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase RHD3 PF05879.10 001309252.1_21026001_2 - 0.0036 15.4 0.0 0.0036 15.4 0.0 2.2 2 0 0 2 2 2 1 Root hair defective 3 GTP-binding protein (RHD3) SSF PF00474.15 001247992.1_21025001_1 - 1.2e-163 544.6 25.2 1.7e-163 544.1 25.2 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family Cation_efflux PF01545.19 001301142.1_21026001_1 - 1.1e-48 165.5 13.4 1.1e-48 165.5 13.4 2.8 3 0 0 3 3 3 1 Cation efflux family Sulfate_transp PF00916.18 001242510.1_21026001_1 - 3.2e-114 381.5 22.5 4.2e-114 381.1 22.5 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.19 001242510.1_21026001_1 - 3.6e-39 132.9 0.2 8e-39 131.8 0.2 1.6 1 0 0 1 1 1 1 STAS domain TMEM51 PF15345.4 001242510.1_21026001_1 - 0.28 10.9 1.5 0.52 10.0 1.5 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 GBP_C PF02841.12 001309256.1_21025001_2 - 3.7e-127 423.7 28.4 5.1e-127 423.2 28.4 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain GBP PF02263.17 001309256.1_21025001_2 - 8.2e-126 418.4 0.0 8.2e-126 418.4 0.0 2.9 3 1 0 3 3 3 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.21 001309256.1_21025001_2 - 0.0012 18.8 0.5 0.0043 17.0 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase RHD3 PF05879.10 001309256.1_21025001_2 - 0.0012 17.0 0.0 0.0012 17.0 0.0 2.2 2 0 0 2 2 2 1 Root hair defective 3 GTP-binding protein (RHD3) zf-NPL4 PF05020.13 001309256.1_21025001_2 - 0.013 15.5 5.9 0.68 9.9 0.2 2.4 2 0 0 2 2 2 0 NPL4 family, putative zinc binding region 6PF2K PF01591.16 001309256.1_21025001_2 - 0.55 9.4 5.2 3.3 6.8 0.1 2.4 2 0 0 2 2 2 0 6-phosphofructo-2-kinase STAT_int PF02865.15 001309256.1_21025001_2 - 6.4 7.1 19.9 16 5.8 9.2 3.6 2 1 1 3 3 3 0 STAT protein, protein interaction domain BTB PF00651.29 001257178.1_21024001_1 - 6.4e-26 90.6 0.2 1.1e-25 89.9 0.2 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 001257178.1_21024001_1 - 8.7e-17 60.4 16.9 3.8e-05 23.8 2.1 4.0 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001257178.1_21024001_1 - 6.4e-15 54.7 16.2 1.5e-07 31.4 0.6 4.5 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 001257178.1_21024001_1 - 1.4e-11 44.0 19.0 0.00038 20.9 0.3 4.4 4 0 0 4 4 3 3 C2H2-type zinc finger zf-met PF12874.5 001257178.1_21024001_1 - 4.6e-08 33.1 9.5 0.0032 17.7 0.3 3.8 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 001257178.1_21024001_1 - 1.1e-05 25.5 6.4 0.2 11.9 0.4 3.8 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding DUF3342 PF11822.6 001257178.1_21024001_1 - 1.2e-05 25.2 0.1 2.8e-05 24.1 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) zf-C2H2_11 PF16622.3 001257178.1_21024001_1 - 2.4e-05 23.9 14.2 0.0054 16.3 0.2 4.1 4 0 0 4 4 4 2 zinc-finger C2H2-type zf-BED PF02892.13 001257178.1_21024001_1 - 0.00024 20.9 14.8 0.2 11.6 0.6 3.6 1 1 2 3 3 3 2 BED zinc finger zf-C2H2_2 PF12756.5 001257178.1_21024001_1 - 0.0012 19.1 8.2 0.13 12.4 0.1 3.9 2 1 2 4 4 4 1 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.4 001257178.1_21024001_1 - 0.0091 15.8 9.2 0.89 9.5 0.3 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger DUF4187 PF13821.4 001257178.1_21024001_1 - 0.021 14.5 2.4 1.6 8.5 0.1 2.8 3 0 0 3 3 2 0 Domain of unknown function (DUF4187) zf-H2C2_5 PF13909.4 001257178.1_21024001_1 - 0.036 13.7 5.6 1.2 8.8 0.1 3.9 3 0 0 3 3 3 0 C2H2-type zinc-finger domain FYDLN_acid PF09538.8 001257178.1_21024001_1 - 0.1 13.1 4.2 16 6.1 0.2 4.0 2 1 2 4 4 4 0 Protein of unknown function (FYDLN_acid) DUF4764 PF15961.3 001257178.1_21024001_1 - 0.15 10.6 12.5 1.5 7.3 0.1 3.1 2 1 0 3 3 3 0 Domain of unknown function (DUF4764) PyrI_C PF02748.13 001257178.1_21024001_1 - 0.41 10.4 7.5 5 7.0 0.1 3.4 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2HE PF16278.3 001257178.1_21024001_1 - 2 8.8 9.5 2.5 8.5 0.1 3.6 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger HNH_5 PF14279.4 001257178.1_21024001_1 - 2.7 7.8 7.3 5.4 6.8 0.1 3.2 3 0 0 3 3 3 0 HNH endonuclease zf-C2HC_2 PF13913.4 001257178.1_21024001_1 - 4.3 7.2 11.7 3.6 7.5 0.1 3.5 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-Di19 PF05605.10 001257178.1_21024001_1 - 4.8 7.4 11.0 0.75 10.0 3.2 2.8 2 1 1 3 3 2 0 Drought induced 19 protein (Di19), zinc-binding zf-trcl PF13451.4 001257178.1_21024001_1 - 7.2 6.5 7.5 6.8 6.5 4.3 2.3 2 0 0 2 2 2 0 Probable zinc-ribbon domain DUF4357 PF14267.4 001257178.1_21024001_2 - 0.092 12.6 1.0 0.12 12.1 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4357) ABC_membrane PF00664.21 001192783.1_06525001_1 - 4.4e-36 124.8 11.7 6e-36 124.4 11.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.25 001192783.1_06525001_1 - 2.6e-34 118.5 0.0 6.2e-34 117.3 0.0 1.7 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.17 001192783.1_06525001_1 - 1.2e-05 24.7 0.1 0.0031 16.9 0.0 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 001192783.1_06525001_1 - 0.0012 19.1 0.0 0.0027 17.9 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.4 001192783.1_06525001_1 - 0.0031 17.1 0.4 0.009 15.6 0.2 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF87 PF01935.15 001192783.1_06525001_1 - 0.012 15.5 0.0 0.027 14.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF87 AAA_28 PF13521.4 001192783.1_06525001_1 - 0.076 13.1 0.0 0.21 11.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.4 001192783.1_06525001_1 - 0.094 12.9 0.0 0.32 11.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.4 001192783.1_06525001_1 - 0.1 12.2 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.14 001192783.1_06525001_1 - 0.12 12.1 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 DUF697 PF05128.10 001192783.1_06525001_1 - 0.24 10.9 4.3 0.64 9.6 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF697) Chromo_shadow PF01393.17 001206415.1_06522001_3 - 1.2e-33 114.8 0.2 2.3e-30 104.3 0.0 2.3 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.22 001206415.1_06522001_3 - 2.5e-21 75.1 0.4 8.9e-18 63.8 0.4 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.4 001206415.1_06522001_3 - 0.0035 17.3 0.2 0.017 15.1 0.2 2.0 2 0 0 2 2 2 1 Polycomb-like MTF2 factor 2 FSIP2 PF15783.3 001206415.1_06522001_3 - 0.31 8.8 2.0 0.42 8.3 2.0 1.0 1 0 0 1 1 1 0 Fibrous sheath-interacting protein 2 ELM2 PF01448.22 001206415.1_06522001_3 - 6.9 7.4 6.1 4 8.1 0.8 2.4 2 1 0 2 2 2 0 ELM2 domain Serpin PF00079.18 001192051.1_06525001_1 - 1.5e-126 422.5 0.0 1.8e-126 422.3 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) GDE_C PF06202.12 001192051.1_06525001_1 - 0.11 11.3 0.0 0.19 10.5 0.0 1.3 1 0 0 1 1 1 0 Amylo-alpha-1,6-glucosidase Spin-Ssty PF02513.15 001105656.2_06523001_1 - 7.7e-76 249.5 9.6 3.8e-27 93.6 0.1 3.4 3 0 0 3 3 3 3 Spin/Ssty Family TP2 PF01254.16 001135102.1_21021001_1 - 1.3e-34 119.6 42.5 8.6e-18 65.1 21.8 2.0 1 1 1 2 2 2 2 Nuclear transition protein 2 Thioredoxin_6 PF13848.4 001205848.1_06524001_1 - 1.2e-27 97.0 12.3 1.5e-25 90.1 3.6 3.4 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin PF00085.18 001205848.1_06524001_1 - 1.6e-22 79.3 0.0 2e-13 50.0 0.0 3.3 3 0 0 3 3 3 2 Thioredoxin OST3_OST6 PF04756.11 001205848.1_06524001_1 - 0.00081 18.7 4.1 0.14 11.4 0.7 2.9 2 1 1 3 3 3 2 OST3 / OST6 family, transporter family ERp29_N PF07912.11 001205848.1_06524001_1 - 0.0022 18.0 0.7 4.1 7.4 0.0 3.1 4 0 0 4 4 4 2 ERp29, N-terminal domain Thioredoxin_8 PF13905.4 001205848.1_06524001_1 - 0.0045 17.2 1.9 0.17 12.1 0.0 4.0 4 2 0 4 4 4 1 Thioredoxin-like Nucleotid_trans PF03407.14 001205848.1_06524001_1 - 0.037 13.8 0.2 0.12 12.1 0.2 1.8 1 1 0 1 1 1 0 Nucleotide-diphospho-sugar transferase Pannexin_like PF12534.6 001257125.1_21026001_3 - 2e-157 523.6 3.9 3e-157 523.0 3.9 1.3 1 0 0 1 1 1 1 Pannexin-like TM region of LRRC8 LRR_8 PF13855.4 001257125.1_21026001_3 - 5.9e-30 102.7 30.2 1.8e-10 40.3 1.6 6.9 3 2 5 8 8 8 5 Leucine rich repeat LRR_4 PF12799.5 001257125.1_21026001_3 - 5.6e-26 90.0 37.4 1.6e-05 25.0 0.7 8.5 4 2 6 11 11 11 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001257125.1_21026001_3 - 1.4e-09 37.6 16.3 1.2e-05 24.8 1.7 3.6 1 1 2 3 3 3 3 Leucine-rich repeat LRR_5 PF13306.4 001257125.1_21026001_3 - 8.9e-09 35.2 5.2 0.00049 19.9 2.4 3.5 3 0 0 3 3 3 3 Leucine rich repeats (6 copies) LRR_1 PF00560.31 001257125.1_21026001_3 - 0.0029 17.7 37.0 7 7.4 0.1 10.5 10 2 0 10 10 10 3 Leucine Rich Repeat LRR_6 PF13516.4 001257125.1_21026001_3 - 5.9 7.1 42.6 1.3 9.2 0.1 8.9 10 0 0 10 10 10 0 Leucine Rich repeat PAP_assoc PF03828.17 001206930.1_06529001_1 - 1.5e-28 98.6 4.8 1.9e-15 56.7 0.2 3.5 3 0 0 3 3 3 2 Cid1 family poly A polymerase zf-CCHC PF00098.21 001206930.1_06529001_1 - 3.8e-11 42.4 20.5 0.00027 20.7 0.5 3.8 3 0 0 3 3 3 3 Zinc knuckle NTP_transf_2 PF01909.21 001206930.1_06529001_1 - 1.9e-10 40.8 0.1 1.5e-08 34.7 0.0 2.8 2 0 0 2 2 2 1 Nucleotidyltransferase domain zf-CCHC_4 PF14392.4 001206930.1_06529001_1 - 0.00028 20.4 15.1 0.12 11.9 0.6 3.6 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.4 001206930.1_06529001_1 - 0.00073 19.2 37.6 0.037 13.7 1.6 5.3 5 0 0 5 5 5 3 Zinc knuckle ATG13 PF10033.7 001242529.1_21025001_1 - 1.2e-12 47.8 0.1 6.3e-07 29.1 0.1 2.7 1 1 1 2 2 2 2 Autophagy-related protein 13 Peptidase_M1 PF01433.18 001309281.1_21029001_1 - 3.1e-133 444.7 0.0 4e-133 444.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.6 001309281.1_21029001_1 - 2.1e-72 244.2 0.1 2.9e-72 243.8 0.1 1.2 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Filament PF00038.19 001346174.1_21024001_3 - 3.8e-99 332.1 20.9 6e-99 331.4 20.9 1.3 1 0 0 1 1 1 1 Intermediate filament protein FliJ PF02050.14 001346174.1_21024001_3 - 0.014 15.5 5.3 0.014 15.5 5.3 2.8 4 0 0 4 4 4 0 Flagellar FliJ protein TPR_MLP1_2 PF07926.10 001346174.1_21024001_3 - 0.015 15.2 2.3 0.015 15.2 2.3 4.4 4 1 1 5 5 5 0 TPR/MLP1/MLP2-like protein Phage_Mu_Gam PF07352.10 001346174.1_21024001_3 - 0.049 13.4 14.9 0.082 12.7 0.3 3.7 4 0 0 4 4 4 0 Bacteriophage Mu Gam like protein Bacillus_HBL PF05791.9 001346174.1_21024001_3 - 0.079 12.6 5.1 0.039 13.6 1.8 2.2 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Reo_sigmaC PF04582.10 001346174.1_21024001_3 - 0.53 9.5 3.5 1.4 8.1 1.8 2.3 1 1 0 2 2 2 0 Reovirus sigma C capsid protein DUF148 PF02520.15 001346174.1_21024001_3 - 1.7 8.6 12.2 1.5 8.9 0.0 4.4 4 1 0 4 4 4 0 Domain of unknown function DUF148 V_ATPase_I PF01496.17 001346174.1_21024001_3 - 2.1 6.0 8.8 0.11 10.2 2.6 1.8 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family FlxA PF14282.4 001346174.1_21024001_3 - 2.2 8.2 16.8 0.091 12.6 5.3 3.2 2 1 1 3 3 3 0 FlxA-like protein DUF1664 PF07889.10 001346174.1_21024001_3 - 3.6 7.4 12.7 0.81 9.6 0.5 4.2 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) She9_MDM33 PF05546.9 001346174.1_21024001_3 - 6 6.5 9.7 4 7.1 0.8 3.3 2 1 1 3 3 3 0 She9 / Mdm33 family DUF4446 PF14584.4 001346174.1_21024001_3 - 9.8 6.0 8.4 6.9 6.5 0.0 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF4446) Filament PF00038.19 001346210.1_21026001_2 - 6e-103 344.6 32.4 7.1e-103 344.3 32.4 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001346210.1_21026001_2 - 2.3e-33 115.5 20.7 2.3e-33 115.5 20.7 2.4 2 0 0 2 2 1 1 Keratin type II head TPR_MLP1_2 PF07926.10 001346210.1_21026001_2 - 4.6e-05 23.3 31.3 0.00018 21.4 11.5 3.5 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.7 001346210.1_21026001_2 - 0.071 13.0 23.5 0.12 12.2 7.1 3.2 2 2 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1192 PF06698.9 001346210.1_21026001_2 - 0.086 12.8 7.4 0.77 9.7 6.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Rab5-bind PF09311.9 001346210.1_21026001_2 - 0.82 8.9 24.3 0.36 10.0 8.8 2.7 1 1 0 2 2 2 0 Rabaptin-like protein DUF1818 PF08848.9 001346210.1_21026001_2 - 1.1 9.3 4.4 18 5.4 0.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF1818) V_ATPase_I PF01496.17 001346210.1_21026001_2 - 1.8 6.2 13.5 0.39 8.4 2.3 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family ADIP PF11559.6 001346210.1_21026001_2 - 2.1 8.3 23.2 0.083 12.8 9.4 2.9 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding BRE1 PF08647.9 001346210.1_21026001_2 - 2.7 8.0 20.7 0.024 14.6 3.1 3.9 2 2 3 5 5 5 0 BRE1 E3 ubiquitin ligase DUF5082 PF16888.3 001346210.1_21026001_2 - 3 8.1 19.0 0.52 10.5 1.4 3.6 2 2 0 3 3 3 0 Domain of unknown function (DUF5082) Jnk-SapK_ap_N PF09744.7 001346210.1_21026001_2 - 3.3 7.8 27.4 1.2 9.2 1.7 3.5 1 1 3 4 4 4 0 JNK_SAPK-associated protein-1 CALCOCO1 PF07888.9 001346210.1_21026001_2 - 3.9 5.8 27.7 0.49 8.8 13.3 2.1 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Ribosomal_S30AE PF02482.17 001346210.1_21026001_2 - 4.6 8.0 5.3 1 10.1 0.9 2.2 2 1 0 2 2 2 0 Sigma 54 modulation protein / S30EA ribosomal protein betaPIX_CC PF16523.3 001346210.1_21026001_2 - 5.1 6.9 10.2 1.2 8.9 1.4 3.0 3 1 0 3 3 3 0 betaPIX coiled coil DUF1664 PF07889.10 001346210.1_21026001_2 - 8.7 6.2 14.0 0.97 9.3 0.3 3.4 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.8 001346210.1_21026001_2 - 9.9 6.2 16.2 0.56 10.2 0.5 3.4 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family Longin PF13774.4 001309225.1_21024001_3 - 3.9e-19 68.3 0.2 6.6e-19 67.6 0.2 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain MHC_I_3 PF16497.3 001252302.1_21023001_1 - 5.7e-100 332.6 3.7 7.2e-100 332.3 3.7 1.1 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001252302.1_21023001_1 - 1.7e-11 44.3 0.0 4.1e-11 43.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001252302.1_21023001_1 - 2.1e-05 24.1 0.0 3.2e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 DUF3377 PF11857.6 001252302.1_21023001_1 - 0.16 11.7 0.0 0.3 10.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Citrate_synt PF00285.19 001195515.1_21024001_1 - 7.1e-106 354.2 0.0 9.3e-106 353.8 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Queuosine_synth PF02547.13 001195515.1_21024001_1 - 0.044 12.8 0.0 0.072 12.1 0.0 1.2 1 0 0 1 1 1 0 Queuosine biosynthesis protein PAS_3 PF08447.10 001195515.1_21024001_1 - 0.058 13.5 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 PAS fold CD225 PF04505.10 001304280.1_21023001_2 - 4.8e-09 36.1 2.4 9.4e-09 35.2 2.4 1.4 1 0 0 1 1 1 1 Interferon-induced transmembrane protein STAG PF08514.9 001354660.1_06529001_1 - 9.7e-38 128.4 0.1 4.1e-37 126.4 0.1 2.1 1 0 0 1 1 1 1 STAG domain AdoHcyase_NAD PF00670.19 001354660.1_06529001_1 - 0.075 13.0 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Kinesin PF00225.21 001206105.1_06529001_1 - 1.1e-114 382.7 0.0 1.1e-114 382.7 0.0 3.3 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.3 001206105.1_06529001_1 - 1.2e-25 90.0 0.2 2e-24 86.1 0.0 3.0 2 0 0 2 2 2 1 Microtubule binding TCR PF03638.13 001206105.1_06529001_1 - 9 6.6 20.3 23 5.3 20.3 1.7 1 0 0 1 1 1 0 Tesmin/TSO1-like CXC domain, cysteine-rich domain Defensin_propep PF00879.16 001166096.1_21021001_1 - 2.5e-23 82.0 6.2 3.3e-23 81.6 6.2 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166096.1_21021001_1 - 1.1e-07 32.1 9.6 2.2e-07 31.2 9.6 1.5 1 0 0 1 1 1 1 Mammalian defensin Filament PF00038.19 001346182.1_21024001_2 - 5.7e-107 357.8 42.0 6.6e-107 357.5 42.0 1.0 1 0 0 1 1 1 1 Intermediate filament protein Lipoprotein_7 PF01540.14 001346182.1_21024001_2 - 0.0033 16.7 0.0 0.0083 15.3 0.0 1.5 1 1 0 1 1 1 1 Adhesin lipoprotein Uso1_p115_C PF04871.11 001346182.1_21024001_2 - 0.028 14.6 23.0 0.47 10.7 5.2 2.9 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF4677 PF15726.3 001346182.1_21024001_2 - 0.037 14.0 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4677) Spc7 PF08317.9 001346182.1_21024001_2 - 0.21 10.3 35.7 0.42 9.3 11.4 2.4 1 1 2 3 3 3 0 Spc7 kinetochore protein Jnk-SapK_ap_N PF09744.7 001346182.1_21024001_2 - 0.77 9.8 39.5 0.66 10.0 8.9 3.7 1 1 2 4 4 4 0 JNK_SAPK-associated protein-1 ERM PF00769.17 001346182.1_21024001_2 - 0.99 9.0 32.7 0.028 14.1 21.1 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Fib_alpha PF08702.8 001346182.1_21024001_2 - 1 9.4 26.1 2.7 8.0 10.1 3.8 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.10 001346182.1_21024001_2 - 2 8.3 20.2 2.8 7.8 0.8 4.1 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.10 001346182.1_21024001_2 - 2.4 8.1 23.6 2.4 8.1 2.4 3.5 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus ADIP PF11559.6 001346182.1_21024001_2 - 3.3 7.6 36.1 0.29 11.1 10.9 3.4 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding DUF972 PF06156.11 001346182.1_21024001_2 - 4.7 7.8 33.0 7 7.2 1.7 5.2 2 2 3 5 5 5 0 Protein of unknown function (DUF972) FliD_C PF07195.10 001346182.1_21024001_2 - 7.7 5.7 11.4 3.1 7.0 5.5 2.4 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus FPP PF05911.9 001346182.1_21024001_2 - 7.8 4.5 35.4 1.6 6.7 16.0 2.1 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil TPR_MLP1_2 PF07926.10 001346182.1_21024001_2 - 9.7 6.1 42.0 8.4 6.3 7.6 4.2 2 2 1 3 3 3 0 TPR/MLP1/MLP2-like protein Endothelin PF00322.15 001163964.1_21022001_1 - 4.2e-24 83.7 13.9 1.6e-21 75.4 3.6 2.4 2 0 0 2 2 2 2 Endothelin family TFIIA PF03153.11 001204845.1_21024001_2 - 5.4e-125 418.5 0.5 6.2e-125 418.3 0.5 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Hirudin PF00713.15 001309470.1_21029001_2 - 0.68 10.2 4.0 1.6 9.0 4.0 1.6 1 0 0 1 1 1 0 Hirudin Patched PF02460.16 001309470.1_21029001_3 - 1.5e-74 251.4 17.6 3.7e-43 147.6 1.1 2.1 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.6 001309470.1_21029001_3 - 7.4e-43 145.9 3.9 7.4e-43 145.9 3.9 2.7 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Tap-RNA_bind PF09162.8 001097607.2_21025001_3 - 1.7e-38 130.2 0.3 4e-38 129.0 0.3 1.6 1 0 0 1 1 1 1 Tap, RNA-binding NTF2 PF02136.18 001097607.2_21025001_3 - 2.7e-27 95.6 0.0 4.6e-27 94.8 0.0 1.4 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain TAP_C PF03943.11 001097607.2_21025001_3 - 3.7e-25 87.1 0.9 6.5e-25 86.4 0.9 1.4 1 0 0 1 1 1 1 TAP C-terminal domain LRR_4 PF12799.5 001097607.2_21025001_3 - 2.5e-06 27.6 7.9 0.00076 19.7 0.9 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001097607.2_21025001_3 - 0.00064 19.3 6.8 0.0017 17.9 6.7 1.8 1 1 0 1 1 1 1 Leucine rich repeat LRR_1 PF00560.31 001097607.2_21025001_3 - 0.02 15.2 5.2 6 7.6 0.2 4.0 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_9 PF14580.4 001097607.2_21025001_3 - 0.024 14.0 0.4 0.045 13.1 0.4 1.4 1 0 0 1 1 1 0 Leucine-rich repeat LRR_6 PF13516.4 001097607.2_21025001_3 - 0.14 12.1 1.8 2.3 8.3 0.0 2.8 2 0 0 2 2 2 0 Leucine Rich repeat Defensin_propep PF00879.16 001166100.1_21021001_1 - 4.8e-22 77.9 1.1 6.5e-22 77.5 1.1 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166100.1_21021001_1 - 0.0032 17.9 10.9 0.0047 17.3 10.9 1.3 1 0 0 1 1 1 1 Mammalian defensin Filament PF00038.19 001346159.1_21024001_1 - 3e-110 368.5 31.8 3.5e-110 368.3 31.8 1.0 1 0 0 1 1 1 1 Intermediate filament protein Lzipper-MIP1 PF14389.4 001346159.1_21024001_1 - 0.0071 16.4 3.8 0.0071 16.4 3.8 4.0 3 2 0 3 3 3 1 Leucine-zipper of ternary complex factor MIP1 TPR_MLP1_2 PF07926.10 001346159.1_21024001_1 - 0.059 13.3 34.7 0.2 11.6 12.3 3.8 3 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N PF09744.7 001346159.1_21024001_1 - 0.13 12.4 29.2 0.85 9.7 9.9 3.5 3 1 0 3 3 3 0 JNK_SAPK-associated protein-1 Rho_Binding PF08912.9 001346159.1_21024001_1 - 0.18 12.5 0.3 0.18 12.5 0.3 4.8 4 1 1 5 5 3 0 Rho Binding DUF1664 PF07889.10 001346159.1_21024001_1 - 0.23 11.3 14.8 4 7.3 0.7 4.0 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) CREPT PF16566.3 001346159.1_21024001_1 - 0.37 10.8 22.1 1.3 9.0 2.7 3.3 3 0 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour ADIP PF11559.6 001346159.1_21024001_1 - 0.44 10.5 26.6 0.54 10.2 11.0 3.4 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Atg14 PF10186.7 001346159.1_21024001_1 - 0.52 9.2 22.9 3.7e+03 -3.4 22.9 2.6 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Uso1_p115_C PF04871.11 001346159.1_21024001_1 - 0.94 9.7 25.3 0.49 10.6 6.7 3.1 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Fib_alpha PF08702.8 001346159.1_21024001_1 - 1.6 8.8 20.4 7.1 6.7 0.1 3.5 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family DivIC PF04977.13 001346159.1_21024001_1 - 1.6 8.4 27.0 0.61 9.8 0.9 5.4 4 1 0 5 5 5 0 Septum formation initiator Baculo_PEP_C PF04513.10 001346159.1_21024001_1 - 1.7 8.6 16.6 5.9 6.8 2.3 3.5 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF5082 PF16888.3 001346159.1_21024001_1 - 2.2 8.5 17.4 0.21 11.8 6.7 3.4 2 2 2 4 4 4 0 Domain of unknown function (DUF5082) Reo_sigmaC PF04582.10 001346159.1_21024001_1 - 2.5 7.3 8.1 1.3 8.3 2.1 2.6 2 1 1 3 3 3 0 Reovirus sigma C capsid protein KLRAQ PF10205.7 001346159.1_21024001_1 - 4.5 7.5 14.8 4.4 7.5 0.4 3.8 3 1 1 4 4 4 0 Predicted coiled-coil domain-containing protein PspA_IM30 PF04012.10 001346159.1_21024001_1 - 5.9 6.3 22.8 0.8 9.1 8.6 3.4 2 1 1 3 3 3 0 PspA/IM30 family Cob_adeno_trans PF01923.16 001346159.1_21024001_1 - 6 6.8 7.4 1.6 8.7 0.7 2.8 1 1 1 2 2 2 0 Cobalamin adenosyltransferase FUSC PF04632.10 001346159.1_21024001_1 - 6.6 5.0 11.3 1.5 7.1 6.9 1.9 1 1 0 2 2 2 0 Fusaric acid resistance protein family Prefoldin_2 PF01920.18 001346159.1_21024001_1 - 7.8 6.4 25.1 2.1 8.2 1.4 4.5 3 2 1 4 4 4 0 Prefoldin subunit PUF PF00806.17 001193123.1_06529001_3 - 5.8e-70 227.1 9.6 9.5e-09 34.3 0.1 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.9 001193123.1_06529001_3 - 0.17 12.1 0.5 8.4 6.6 0.1 3.2 1 1 1 2 2 2 0 CPL (NUC119) domain V1R PF03402.12 001166869.1_21022001_1 - 1.7e-33 116.3 12.3 2.2e-33 115.9 12.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001166869.1_21022001_1 - 9.6e-06 24.9 9.1 1.3e-05 24.5 9.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001166869.1_21022001_1 - 5.1e-05 22.4 13.8 6.8e-05 22.0 13.8 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Pex24p PF06398.9 001166869.1_21022001_1 - 0.055 12.3 6.3 0.099 11.5 6.3 1.4 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin DUF2768 PF10966.6 001166869.1_21022001_1 - 0.99 9.8 0.1 0.99 9.8 0.1 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF2768) p450 PF00067.20 001291302.1_21023001_1 - 2.7e-166 553.8 0.0 3.1e-166 553.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3973 PF13119.4 001291302.1_21023001_1 - 6.9 6.9 6.5 1.1e+02 3.0 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF3973) MHC_I_3 PF16497.3 001252301.1_21023001_1 - 5.5e-74 247.8 0.3 8.5e-74 247.2 0.3 1.3 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001252301.1_21023001_1 - 1.6e-11 44.4 0.0 5.7e-11 42.6 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001252301.1_21023001_1 - 9.5e-07 28.4 0.0 1.5e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Ig_3 PF13927.4 001252301.1_21023001_1 - 0.015 15.7 0.1 1.3 9.5 0.0 2.4 1 1 1 2 2 2 0 Immunoglobulin domain ig PF00047.23 001252301.1_21023001_1 - 0.04 13.9 0.0 0.88 9.6 0.0 2.5 2 1 1 3 3 3 0 Immunoglobulin domain TMEM132D_C PF15706.3 001252301.1_21023001_1 - 0.082 12.6 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term ECSCR PF15820.3 001252301.1_21023001_1 - 0.17 11.6 0.2 0.29 10.9 0.2 1.3 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Phospholamban PF04272.12 001252301.1_21023001_1 - 2.8 7.4 8.2 6.1 6.3 8.2 1.5 1 0 0 1 1 1 0 Phospholamban Leptin PF02024.13 001163980.1_21022001_1 - 2.5e-72 241.3 1.1 2.8e-72 241.1 1.1 1.0 1 0 0 1 1 1 1 Leptin Syntaxin_2 PF14523.4 001163980.1_21022001_1 - 1.3 9.3 5.1 7.1 6.9 1.2 2.7 1 1 1 2 2 2 0 Syntaxin-like protein AAA_12 PF13087.4 001301207.1_21029001_2 - 8.3e-35 120.1 0.0 1.5e-34 119.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.4 001301207.1_21029001_2 - 2.3e-26 93.0 0.2 7.5e-14 52.0 0.2 2.7 1 1 1 2 2 2 2 AAA domain AAA_19 PF13245.4 001301207.1_21029001_2 - 8.5e-10 39.0 0.0 9.1e-08 32.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.4 001301207.1_21029001_2 - 1.2e-08 34.8 0.0 4.9e-08 32.8 0.0 2.0 2 1 0 2 2 2 1 AAA domain zf-CCCH PF00642.22 001301207.1_21029001_2 - 8e-08 31.9 0.6 1.9e-07 30.7 0.6 1.7 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) UvrD-helicase PF00580.19 001301207.1_21029001_2 - 1.2e-05 24.9 0.5 8.7e-05 22.0 0.0 2.6 3 0 0 3 3 3 1 UvrD/REP helicase N-terminal domain ResIII PF04851.13 001301207.1_21029001_2 - 2.3e-05 24.3 0.0 4.9e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.14 001301207.1_21029001_2 - 9.9e-05 21.7 0.0 0.015 14.6 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein PAM2 PF07145.13 001301207.1_21029001_2 - 0.0003 20.1 0.1 0.0011 18.4 0.1 2.1 1 0 0 1 1 1 1 Ataxin-2 C-terminal region AAA_22 PF13401.4 001301207.1_21029001_2 - 0.06 13.5 0.0 0.21 11.7 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 001301207.1_21029001_2 - 0.07 13.4 0.0 0.35 11.1 0.0 2.2 3 0 0 3 3 1 0 AAA ATPase domain Bac_DnaA PF00308.16 001301207.1_21029001_2 - 0.075 12.7 0.7 0.23 11.1 0.0 2.1 3 0 0 3 3 3 0 Bacterial dnaA protein Helicase_RecD PF05127.12 001301207.1_21029001_2 - 0.075 12.7 0.1 0.29 10.8 0.0 2.1 2 0 0 2 2 2 0 Helicase TetR_C_8 PF14278.4 001301207.1_21029001_2 - 0.1 12.8 0.8 1.5 9.0 0.1 3.1 3 0 0 3 3 3 0 Transcriptional regulator C-terminal region Mg_chelatase PF01078.19 001301207.1_21029001_2 - 0.14 11.4 0.0 0.3 10.3 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TPR_1 PF00515.26 001301207.1_21029001_2 - 0.15 11.8 1.6 2.6 7.9 0.3 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TRAM_LAG1_CLN8 PF03798.14 001301183.1_21029001_3 - 1.1e-36 126.3 26.2 2.4e-36 125.2 26.2 1.6 1 0 0 1 1 1 1 TLC domain Homeobox PF00046.27 001301183.1_21029001_3 - 1.1e-06 28.2 0.5 2.5e-06 27.1 0.5 1.6 1 0 0 1 1 1 1 Homeobox domain AlbA_2 PF04326.12 001257128.1_21029001_1 - 1.5e-05 25.2 0.9 6.2e-05 23.2 0.9 2.2 1 0 0 1 1 1 1 Putative DNA-binding domain SAM_2 PF07647.15 001257128.1_21029001_1 - 0.00091 19.2 0.3 0.0038 17.2 0.1 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 001257128.1_21029001_1 - 0.012 15.9 0.1 0.031 14.6 0.1 1.7 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Ste50p-SAM PF09235.8 001257128.1_21029001_1 - 0.042 14.0 0.7 0.11 12.7 0.1 2.1 2 0 0 2 2 2 0 Ste50p, sterile alpha motif APOBEC_N PF08210.9 001163681.1_21023001_1 - 9.3e-94 312.2 7.4 1.1e-46 158.8 1.1 2.0 2 0 0 2 2 2 2 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001163681.1_21023001_1 - 1.6e-55 184.8 0.7 1.2e-27 95.5 0.0 2.4 2 0 0 2 2 2 2 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 001163681.1_21023001_1 - 0.00037 20.2 0.2 0.31 10.8 0.0 2.3 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region Toxin-deaminase PF14424.4 001163681.1_21023001_1 - 0.00061 19.8 0.0 1.1 9.2 0.0 2.2 2 0 0 2 2 2 2 The BURPS668_1122 family of deaminases Sgf11 PF08209.9 001163681.1_21023001_1 - 0.0024 17.2 1.7 1.2 8.6 0.1 2.5 2 0 0 2 2 2 2 Sgf11 (transcriptional regulation protein) Hairy_orange PF07527.11 001163681.1_21023001_1 - 0.0034 17.4 0.2 1.4 9.0 0.0 2.5 2 0 0 2 2 2 2 Hairy Orange Pox_A3L PF05288.9 001163681.1_21023001_1 - 0.0035 17.2 0.1 4.3 7.3 0.0 2.6 2 0 0 2 2 2 2 Poxvirus A3L Protein Tox-PL-2 PF15643.4 001163681.1_21023001_1 - 0.017 15.1 0.2 6.3 6.9 0.1 2.4 2 0 0 2 2 2 0 Papain fold toxin 2 DUF1885 PF08968.8 001163681.1_21023001_1 - 0.045 13.7 1.3 4.4 7.3 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1885) FGF PF00167.16 001163681.1_21023001_1 - 0.12 12.3 0.1 20 5.2 0.0 2.4 2 0 0 2 2 2 0 Fibroblast growth factor UPF0203 PF05254.10 001163681.1_21023001_1 - 0.34 11.1 9.2 4.1 7.6 1.5 2.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0203) Eclosion PF04736.10 001163681.1_21023001_1 - 7 6.3 10.3 1.7 8.2 0.2 3.7 4 1 0 4 4 4 0 Eclosion hormone Trypsin PF00089.24 174202.3_06523001_3 - 6.9e-71 238.4 0.2 8.1e-71 238.2 0.2 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 174202.3_06523001_3 - 3.3e-07 31.2 0.0 5.7e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 174202.3_06523001_3 - 9.3e-05 22.7 0.1 0.00017 21.8 0.1 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Ank_2 PF12796.5 001257082.1_21024001_1 - 1.4e-16 60.7 0.4 4.9e-13 49.3 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001257082.1_21024001_1 - 9.1e-16 57.9 0.1 1.2e-05 25.6 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 001257082.1_21024001_1 - 1.9e-13 50.2 0.2 0.0019 18.4 0.0 4.0 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.28 001257082.1_21024001_1 - 5.8e-13 48.5 0.5 3e-05 24.1 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.4 001257082.1_21024001_1 - 6.1e-10 38.4 0.1 0.0058 16.9 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat zf-BED PF02892.13 001256974.1_21028001_1 - 2.4e-62 206.6 28.7 9.7e-17 60.6 0.5 4.6 4 0 0 4 4 4 4 BED zinc finger Dimer_Tnp_hAT PF05699.12 001256974.1_21028001_1 - 9.6e-08 31.6 0.1 9.6e-08 31.6 0.1 2.4 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region PyrI_C PF02748.13 001256974.1_21028001_1 - 0.0011 18.7 4.0 1.9 8.3 0.1 4.2 4 0 0 4 4 4 2 Aspartate carbamoyltransferase regulatory chain, metal binding domain DUF1289 PF06945.11 001256974.1_21028001_1 - 0.053 13.2 0.6 0.21 11.3 0.6 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1289) zf-H2C2_2 PF13465.4 001301293.1_21029001_1 - 2.4e-61 201.4 73.4 1.6e-09 37.7 0.9 10.8 11 0 0 11 11 10 8 Zinc-finger double domain zf-C2H2 PF00096.24 001301293.1_21029001_1 - 1.7e-47 157.1 75.5 1.1e-06 28.6 4.5 10.3 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001301293.1_21029001_1 - 1e-24 84.9 78.7 0.0044 17.6 1.2 11.1 11 0 0 11 11 11 9 C2H2-type zinc finger KRAB PF01352.25 001301293.1_21029001_1 - 2.2e-24 84.7 0.1 3.7e-24 84.0 0.1 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 001301293.1_21029001_1 - 7.5e-17 60.7 67.2 0.0011 18.8 0.7 10.1 10 0 0 10 10 10 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001301293.1_21029001_1 - 1.6e-08 34.5 34.9 0.15 12.3 0.7 8.8 8 0 0 8 8 8 5 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 001301293.1_21029001_1 - 0.0012 18.8 49.7 0.1 12.6 3.0 7.4 3 2 6 9 9 9 5 Zinc ribbon domain HypA PF01155.17 001301293.1_21029001_1 - 0.0083 16.0 25.8 0.17 11.8 1.0 4.5 1 1 3 4 4 4 3 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.3 001301293.1_21029001_1 - 0.011 16.3 38.5 0.31 11.7 2.0 5.2 2 2 1 4 4 4 0 zinc-ribbon family zf-C2HE PF16278.3 001301293.1_21029001_1 - 0.053 13.8 0.2 0.053 13.8 0.2 8.5 3 3 4 7 7 7 0 C2HE / C2H2 / C2HC zinc-binding finger C1_4 PF07975.10 001301293.1_21029001_1 - 0.062 13.4 38.9 0.2 11.8 1.3 5.5 3 1 1 5 5 5 0 TFIIH C1-like domain zf-C2HC_2 PF13913.4 001301293.1_21029001_1 - 0.13 12.0 25.1 1.6 8.6 0.1 7.0 7 0 0 7 7 7 0 zinc-finger of a C2HC-type XPA_N PF01286.16 001301293.1_21029001_1 - 4.6 7.2 40.5 2.4 8.2 0.2 9.3 10 0 0 10 10 9 0 XPA protein N-terminal RRM_1 PF00076.20 001256920.1_21026001_1 - 1.5e-27 95.1 4.9 4.9e-07 29.3 0.2 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FKBP_C PF00254.26 001309461.1_21023001_3 - 1.1e-16 60.7 0.0 2e-16 59.9 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.15 001309461.1_21023001_3 - 5.8e-05 22.8 6.9 0.017 15.0 0.2 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.4 001309461.1_21023001_3 - 6.3e-05 23.1 4.5 0.018 15.2 1.0 3.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.4 001309461.1_21023001_3 - 0.019 15.3 1.5 0.028 14.8 0.5 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3813 PF12758.5 001309461.1_21023001_3 - 0.035 14.3 0.3 0.1 12.8 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3813) TPR_1 PF00515.26 001309461.1_21023001_3 - 0.085 12.6 4.1 0.48 10.2 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.4 001309461.1_21023001_3 - 0.11 12.1 0.1 0.47 10.1 0.0 2.1 2 0 0 2 2 2 0 TPR repeat WD40 PF00400.30 001301271.1_21029001_1 - 2e-46 154.9 32.4 5.8e-07 30.0 0.1 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.6 001301271.1_21029001_1 - 1.5e-13 50.1 13.4 0.04 12.4 0.1 6.5 2 1 3 6 6 6 6 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.5 001301271.1_21029001_1 - 6.9e-13 48.6 7.2 0.027 14.7 0.1 6.9 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.5 001301271.1_21029001_1 - 6.9e-13 48.1 1.2 1.3e-12 47.3 1.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001301271.1_21029001_1 - 1.3e-08 34.3 0.2 2.3e-08 33.6 0.2 1.4 1 0 0 1 1 1 1 F-box domain PQQ_2 PF13360.4 001301271.1_21029001_1 - 2.5e-05 23.9 2.4 0.00021 20.8 1.9 2.7 1 1 0 1 1 1 1 PQQ-like domain Ge1_WD40 PF16529.3 001301271.1_21029001_1 - 0.0037 16.2 9.8 2.2 7.0 0.2 4.7 1 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein CDtoxinA PF03498.12 001301271.1_21029001_1 - 0.011 15.2 1.7 0.39 10.2 0.3 2.9 2 1 0 2 2 2 0 Cytolethal distending toxin A/C domain PALB2_WD40 PF16756.3 001301271.1_21029001_1 - 0.059 12.2 6.7 0.17 10.7 0.2 4.1 2 2 3 5 5 5 0 Partner and localizer of BRCA2 WD40 domain Hira PF07569.9 001301271.1_21029001_1 - 0.1 12.2 1.6 27 4.2 0.0 4.0 2 2 2 4 4 4 0 TUP1-like enhancer of split Nop14 PF04147.10 001301271.1_21029001_1 - 0.72 7.9 28.0 1.1 7.2 28.0 1.2 1 0 0 1 1 1 0 Nop14-like family LRR_8 PF13855.4 001309288.1_21029001_1 - 1e-35 121.1 75.6 1.2e-08 34.5 1.9 7.8 3 1 9 12 12 12 11 Leucine rich repeat LRR_4 PF12799.5 001309288.1_21029001_1 - 3.3e-26 90.7 46.4 0.00029 21.0 0.0 10.1 6 2 3 11 11 11 10 Leucine Rich repeats (2 copies) PDZ PF00595.22 001309288.1_21029001_1 - 8.4e-14 51.6 0.0 1.7e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) LRR_5 PF13306.4 001309288.1_21029001_1 - 6.1e-06 26.1 2.3 0.012 15.5 0.2 3.6 1 1 1 3 3 3 1 Leucine rich repeats (6 copies) PDZ_2 PF13180.4 001309288.1_21029001_1 - 0.00013 22.1 0.0 0.00041 20.5 0.0 1.8 1 0 0 1 1 1 1 PDZ domain Rod_C PF10493.7 001192091.2_06529001_3 - 2.6e-255 847.9 14.5 2.6e-255 847.9 14.5 2.2 2 0 0 2 2 2 1 Rough deal protein C-terminal region MRP-S22 PF10245.7 001192091.2_06529001_3 - 0.037 13.6 0.5 0.1 12.2 0.2 1.9 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S22 DUF1844 PF08899.9 001192091.2_06529001_3 - 0.077 13.2 0.1 0.24 11.6 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1844) MHC_I_3 PF16497.3 001252305.1_21023001_1 - 1.1e-97 325.2 0.4 1.4e-97 324.8 0.4 1.2 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001252305.1_21023001_1 - 2e-10 40.9 0.0 3.9e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001252305.1_21023001_1 - 9.7e-07 28.4 0.0 1.6e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 DUF4381 PF14316.4 001252305.1_21023001_1 - 0.65 10.1 3.4 0.4 10.8 0.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) V1R PF03402.12 001166861.1_21022001_1 - 1.9e-33 116.1 17.4 2.5e-33 115.7 17.4 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001166861.1_21022001_1 - 9.6e-05 21.6 16.6 0.00014 21.1 16.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Filament PF00038.19 001346216.1_21024001_3 - 1.3e-100 336.9 31.9 1.5e-100 336.7 31.9 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001346216.1_21024001_3 - 8.5e-12 45.4 8.0 8.5e-12 45.4 8.0 2.7 2 1 0 2 2 1 1 Keratin type II head TPR_MLP1_2 PF07926.10 001346216.1_21024001_3 - 1.6e-06 28.1 25.1 9.8e-05 22.3 0.8 3.4 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein Spc7 PF08317.9 001346216.1_21024001_3 - 0.00041 19.2 23.4 0.017 13.9 11.3 2.9 1 1 1 2 2 2 2 Spc7 kinetochore protein Tropomyosin_1 PF12718.5 001346216.1_21024001_3 - 0.002 18.2 10.3 0.002 18.2 10.3 3.5 3 1 1 4 4 4 1 Tropomyosin like CALCOCO1 PF07888.9 001346216.1_21024001_3 - 0.0097 14.4 21.6 0.005 15.3 11.3 2.2 1 1 0 2 2 2 1 Calcium binding and coiled-coil domain (CALCOCO1) like BAT PF15915.3 001346216.1_21024001_3 - 0.018 14.8 0.4 0.042 13.6 0.3 1.7 1 1 0 1 1 1 0 GAF and HTH_10 associated domain BRE1 PF08647.9 001346216.1_21024001_3 - 0.029 14.3 0.7 0.029 14.3 0.7 3.4 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase Alanine_zipper PF11839.6 001346216.1_21024001_3 - 0.086 13.0 7.2 0.084 13.0 5.5 1.8 2 0 0 2 2 1 0 Alanine-zipper, major outer membrane lipoprotein MRFAP1 PF15155.4 001346216.1_21024001_3 - 0.093 13.1 7.5 0.075 13.4 3.2 2.6 2 1 0 2 2 2 0 MORF4 family-associated protein1 DUF3355 PF11835.6 001346216.1_21024001_3 - 0.17 11.5 0.6 0.38 10.3 0.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3355) DUF641 PF04859.10 001346216.1_21024001_3 - 0.17 12.1 10.5 1.9 8.7 2.8 2.6 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Prefoldin PF02996.15 001346216.1_21024001_3 - 0.19 11.5 13.0 0.14 12.0 0.4 3.9 3 1 0 4 4 3 0 Prefoldin subunit DUF1635 PF07795.9 001346216.1_21024001_3 - 0.3 10.9 4.9 0.57 10.0 4.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) DASH_Duo1 PF08651.8 001346216.1_21024001_3 - 0.79 9.4 8.5 0.38 10.4 3.0 2.8 3 0 0 3 3 2 0 DASH complex subunit Duo1 FlaC_arch PF05377.9 001346216.1_21024001_3 - 0.87 9.9 9.0 3.8 7.9 1.5 4.1 3 1 0 4 4 4 0 Flagella accessory protein C (FlaC) DASH_Dad4 PF08650.8 001346216.1_21024001_3 - 1.1 9.2 5.5 0.47 10.3 1.8 2.3 2 0 0 2 2 1 0 DASH complex subunit Dad4 DUF4407 PF14362.4 001346216.1_21024001_3 - 1.3 8.1 16.7 99 2.0 16.7 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Reo_sigmaC PF04582.10 001346216.1_21024001_3 - 1.5 8.0 3.3 5.5 6.2 2.3 2.1 1 1 0 1 1 1 0 Reovirus sigma C capsid protein DUF812 PF05667.9 001346216.1_21024001_3 - 1.6 7.4 21.6 0.2 10.3 12.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF812) DUF4200 PF13863.4 001346216.1_21024001_3 - 1.7 8.9 22.2 0.54 10.5 4.2 3.5 2 2 0 3 3 3 0 Domain of unknown function (DUF4200) MCC-bdg_PDZ PF10506.7 001346216.1_21024001_3 - 1.9 8.4 10.7 1 9.3 3.1 3.1 2 1 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome TSNAXIP1_N PF15739.3 001346216.1_21024001_3 - 2.7 8.3 16.0 0.055 13.7 3.2 3.4 2 2 2 4 4 4 0 Translin-associated factor X-interacting N-terminus Virulence_fact PF13769.4 001346216.1_21024001_3 - 3.5 7.7 5.6 2.7 8.0 0.1 3.1 3 0 0 3 3 3 0 Virulence factor BST2 PF16716.3 001346216.1_21024001_3 - 3.6 8.1 12.4 6.5 7.3 5.1 2.9 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 DUF1664 PF07889.10 001346216.1_21024001_3 - 4.4 7.2 9.2 8.9 6.2 2.5 3.3 1 1 3 5 5 5 0 Protein of unknown function (DUF1664) CHDCT2 PF08074.9 001346216.1_21024001_3 - 5.9 6.9 11.7 3.3 7.7 1.0 2.8 1 1 2 3 3 3 0 CHDCT2 (NUC038) domain DUF1192 PF06698.9 001346216.1_21024001_3 - 6.6 6.7 13.2 0.57 10.1 0.6 3.4 4 0 0 4 4 3 0 Protein of unknown function (DUF1192) Fib_alpha PF08702.8 001346216.1_21024001_3 - 7.5 6.6 14.2 4.1 7.4 4.8 3.4 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family ADIP PF11559.6 001346216.1_21024001_3 - 8.7 6.3 22.8 0.13 12.2 8.0 3.2 3 1 0 3 3 3 0 Afadin- and alpha -actinin-Binding DUF2205 PF10224.7 001346216.1_21024001_3 - 10 6.1 9.4 1.5 8.7 0.7 3.4 3 0 0 3 3 3 0 Predicted coiled-coil protein (DUF2205) Phtf-FEM1B_bdg PF12129.6 001309229.1_21029001_3 - 2.5e-72 241.6 0.7 2.5e-72 241.6 0.7 2.9 3 0 0 3 3 3 1 Male germ-cell putative homeodomain transcription factor GATase_6 PF13522.4 001105316.1_21024001_2 - 4.6e-15 55.9 0.0 8.3e-15 55.0 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.4 001105316.1_21024001_2 - 7.2e-13 48.4 0.0 1.2e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.4 001105316.1_21024001_2 - 5.8e-08 31.8 0.0 9e-08 31.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Pribosyltran PF00156.25 001105316.1_21024001_2 - 3.5e-07 29.7 0.0 6e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.4 001105316.1_21024001_2 - 0.022 14.1 0.0 0.037 13.4 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase UPRTase PF14681.4 001105316.1_21024001_2 - 0.042 13.1 0.0 0.067 12.5 0.0 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase PP2C PF00481.19 001257150.1_21024001_1 - 6.3e-38 130.7 0.0 6.5e-36 124.1 0.0 2.2 1 1 0 1 1 1 1 Protein phosphatase 2C Filament PF00038.19 001346221.1_21027001_2 - 7.2e-82 275.3 36.4 8.8e-82 275.0 36.4 1.1 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001346221.1_21027001_2 - 4.1e-10 39.9 0.1 8.4e-10 38.9 0.1 1.5 1 0 0 1 1 1 1 Keratin type II head Mago-bind PF09282.8 001346221.1_21027001_2 - 0.1 12.3 0.9 0.26 11.1 0.9 1.6 1 0 0 1 1 1 0 Mago binding DUF342 PF03961.11 001346221.1_21027001_2 - 3.7 5.9 16.0 3.9 5.8 4.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF342) Reo_sigmaC PF04582.10 001346221.1_21027001_2 - 5.3 6.2 9.4 5.5 6.2 4.2 2.6 1 1 2 3 3 3 0 Reovirus sigma C capsid protein SKIP_SNW PF02731.13 001346221.1_21027001_2 - 8.6 5.9 16.5 3.2 7.3 0.2 3.9 4 0 0 4 4 4 0 SKIP/SNW domain BRE1 PF08647.9 001346221.1_21027001_2 - 8.9 6.3 36.1 1.2 9.1 9.1 4.0 3 1 1 4 4 4 0 BRE1 E3 ubiquitin ligase Ras PF00071.20 001195523.1_21022001_1 - 1.7e-42 144.6 0.3 2.3e-42 144.2 0.3 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001195523.1_21022001_1 - 7.8e-24 84.1 0.1 1.8e-23 82.9 0.1 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001195523.1_21022001_1 - 1.3e-14 53.9 0.0 1.9e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DnaJ PF00226.29 001195523.1_21022001_1 - 7.7e-12 45.0 0.0 1.3e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain MMR_HSR1 PF01926.21 001195523.1_21022001_1 - 1.1e-05 25.3 0.0 2.9e-05 24.0 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001195523.1_21022001_1 - 0.00032 20.0 0.1 0.00042 19.6 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001195523.1_21022001_1 - 0.00066 19.1 0.2 0.002 17.6 0.2 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.16 001195523.1_21022001_1 - 0.08 12.3 0.0 0.5 9.7 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B Sgf11 PF08209.9 001192608.1_06529001_1 - 9.3e-18 63.4 2.8 3e-17 61.7 2.8 2.0 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) SCA7 PF08313.10 001192608.1_06529001_1 - 1.3e-06 28.1 2.3 3.6e-06 26.7 2.3 1.7 1 0 0 1 1 1 1 SCA7, zinc-binding domain T-box PF00907.20 001191443.1_06527001_2 - 2.3e-85 285.3 0.1 3e-85 285.0 0.1 1.1 1 0 0 1 1 1 1 T-box TBX PF12598.6 001191443.1_06527001_2 - 5.3e-23 81.5 5.6 5.3e-23 81.5 5.6 2.4 2 0 0 2 2 2 1 T-box transcription factor IL8 PF00048.18 001143793.2_21023001_2 - 1.3e-13 50.8 1.3 2.1e-13 50.1 1.3 1.4 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Rdx PF10262.7 001170422.1_21022001_2 - 5.3e-05 23.2 0.0 8.5e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Rdx family MACPF PF01823.17 001257155.1_21025001_1 - 6e-28 98.2 0.0 2.7e-27 96.1 0.0 1.9 2 0 0 2 2 2 1 MAC/Perforin domain Translin PF01997.14 001076006.3_06525001_2 - 1.4e-59 201.4 0.1 1.9e-59 200.9 0.1 1.2 1 0 0 1 1 1 1 Translin family CDP-OH_P_transf PF01066.19 001168391.1_21029001_1 - 6.2e-16 58.8 0.1 6.2e-16 58.8 0.1 2.9 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase zf-H2C2_2 PF13465.4 001257136.1_21024001_1 - 2.1e-67 220.6 51.3 1.1e-08 35.1 0.2 10.3 10 0 0 10 10 10 10 Zinc-finger double domain zf-C2H2 PF00096.24 001257136.1_21024001_1 - 2.8e-46 153.3 59.5 7.8e-06 25.9 0.7 9.4 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001257136.1_21024001_1 - 6.9e-27 91.7 60.0 0.0021 18.6 1.1 9.5 9 0 0 9 9 9 9 C2H2-type zinc finger KRAB PF01352.25 001257136.1_21024001_1 - 1.1e-22 79.2 0.3 1.9e-22 78.5 0.3 1.4 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 001257136.1_21024001_1 - 1.8e-10 40.7 30.4 0.00096 19.1 2.5 6.6 5 3 2 7 7 7 4 Zinc ribbon domain zf-C2H2_jaz PF12171.6 001257136.1_21024001_1 - 8.1e-10 38.6 22.2 0.0098 16.1 0.1 8.2 9 0 0 9 9 8 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001257136.1_21024001_1 - 6.9e-09 35.3 56.8 0.068 13.0 0.3 9.9 9 2 0 9 9 9 5 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 001257136.1_21024001_1 - 0.00015 22.4 21.5 0.71 10.5 0.7 5.0 1 1 4 5 5 5 2 zinc-ribbon family zf-C2H2_11 PF16622.3 001257136.1_21024001_1 - 0.00035 20.1 53.2 0.13 11.9 1.0 9.0 9 0 0 9 9 9 4 zinc-finger C2H2-type HypA PF01155.17 001257136.1_21024001_1 - 0.0023 17.8 21.6 0.52 10.2 2.2 4.6 1 1 2 3 3 3 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA C1_4 PF07975.10 001257136.1_21024001_1 - 0.0028 17.7 31.2 0.6 10.3 3.2 6.2 1 1 7 8 8 8 4 TFIIH C1-like domain ADK_lid PF05191.12 001257136.1_21024001_1 - 0.066 13.1 12.5 19 5.2 0.5 6.0 4 4 2 6 6 6 0 Adenylate kinase, active site lid zf-AN1 PF01428.14 001257136.1_21024001_1 - 0.43 10.7 44.6 1.3 9.2 3.5 8.9 6 3 3 9 9 9 0 AN1-like Zinc finger FYDLN_acid PF09538.8 001257136.1_21024001_1 - 0.45 11.1 15.8 7.7 7.1 0.1 6.7 2 2 5 7 7 7 0 Protein of unknown function (FYDLN_acid) LIM PF00412.20 001257136.1_21024001_1 - 0.57 10.3 35.6 2.8 8.1 2.1 6.7 3 2 3 6 6 6 0 LIM domain BolA PF01722.16 001257136.1_21024001_1 - 0.82 9.9 11.6 16 5.7 2.5 4.5 2 2 1 4 4 4 0 BolA-like protein zf-LYAR PF08790.9 001257136.1_21024001_1 - 1.1 9.1 31.6 7 6.5 0.3 8.6 9 0 0 9 9 9 0 LYAR-type C2HC zinc finger zf-UBP PF02148.17 001257136.1_21024001_1 - 1.6 9.0 35.3 33 4.8 0.2 5.7 1 1 1 2 2 1 0 Zn-finger in ubiquitin-hydrolases and other protein zf-C2HE PF16278.3 001257136.1_21024001_1 - 2.1 8.7 41.8 2.8 8.3 0.3 8.2 1 1 6 7 7 7 0 C2HE / C2H2 / C2HC zinc-binding finger GAGA PF09237.9 001257136.1_21024001_1 - 2.6 7.8 17.4 1.2 8.9 0.7 4.8 4 2 1 6 6 4 0 GAGA factor Ta0938 PF11494.6 001257136.1_21024001_1 - 3.1 8.0 8.0 0.69 10.1 0.1 3.3 2 2 2 4 4 4 0 Ta0938 DUF3268 PF11672.6 001257136.1_21024001_1 - 3.2 8.0 20.4 7.3 6.8 0.7 4.5 1 1 7 8 8 8 0 zinc-finger-containing domain zf-C2HC_2 PF13913.4 001257136.1_21024001_1 - 4 7.3 22.6 0.48 10.3 0.4 5.7 5 0 0 5 5 5 0 zinc-finger of a C2HC-type IBR PF01485.19 001257136.1_21024001_1 - 7.9 6.7 30.4 53 4.0 3.1 5.1 1 1 1 3 3 3 0 IBR domain, a half RING-finger domain Stig1 PF04885.11 001257136.1_21024001_1 - 9.5 6.6 16.4 11 6.3 4.1 2.4 1 1 1 2 2 2 0 Stigma-specific protein, Stig1 mit_SMPDase PF14724.4 001257136.1_21024001_2 - 0.091 10.6 2.2 0.13 10.0 2.2 1.1 1 0 0 1 1 1 0 Mitochondrial-associated sphingomyelin phosphodiesterase Basic PF01586.14 001317257.1_21022001_2 - 5.4e-23 81.8 0.2 1.4e-22 80.5 0.0 1.8 2 1 0 2 2 2 1 Myogenic Basic domain HLH PF00010.24 001317257.1_21022001_2 - 4e-13 49.0 5.8 6.5e-13 48.3 5.8 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Myf5 PF12232.6 001317257.1_21022001_2 - 0.00096 19.7 1.9 0.00096 19.7 1.9 1.8 2 0 0 2 2 2 1 Myogenic determination factor 5 LRR_8 PF13855.4 001163868.1_21025001_3 - 5.5e-66 218.1 48.9 2.7e-18 65.3 0.7 5.7 1 1 4 6 6 6 6 Leucine rich repeat 7tm_1 PF00001.19 001163868.1_21025001_3 - 4.9e-21 75.0 16.3 4.9e-21 75.0 16.3 2.1 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) LRR_5 PF13306.4 001163868.1_21025001_3 - 1.4e-18 66.9 4.7 2.9e-09 36.9 1.0 2.8 1 1 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 001163868.1_21025001_3 - 2.3e-14 53.1 29.1 2.2e-05 24.5 2.2 7.0 2 1 6 8 8 8 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001163868.1_21025001_3 - 2.6e-09 36.7 10.8 0.00026 20.4 1.1 3.3 1 1 2 3 3 3 3 Leucine-rich repeat Ldl_recept_a PF00057.16 001163868.1_21025001_3 - 4.9e-09 36.1 3.3 4.9e-09 36.1 3.3 2.0 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A LRR_1 PF00560.31 001163868.1_21025001_3 - 0.12 12.8 21.0 1.6 9.4 0.2 7.5 7 2 0 7 7 7 0 Leucine Rich Repeat RMI1_N PF08585.10 001256939.1_21024001_1 - 1.1e-55 188.6 0.2 2.4e-55 187.5 0.2 1.6 1 0 0 1 1 1 1 RecQ mediated genome instability protein RMI1_C PF16099.3 001256939.1_21024001_1 - 1.4e-44 151.3 0.1 3.4e-44 150.0 0.1 1.7 1 0 0 1 1 1 1 Recq-mediated genome instability protein 1, C-terminal OB-fold Hepcidin PF06446.10 001168327.2_21021001_1 - 1.3e-15 57.3 9.7 1.3e-15 57.3 9.7 1.6 2 0 0 2 2 2 1 Hepcidin TNF PF00229.16 001242445.1_21022001_1 - 9.3e-10 38.4 0.0 1.6e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family PRORP PF16953.3 001301261.1_21025001_1 - 1.6e-103 345.3 0.2 2.3e-103 344.8 0.2 1.2 1 0 0 1 1 1 1 Protein-only RNase P PPR_2 PF13041.4 001301261.1_21025001_1 - 0.022 14.8 0.0 8.2 6.6 0.0 3.4 2 1 1 3 3 3 0 PPR repeat family PPR PF01535.18 001301261.1_21025001_1 - 0.044 13.9 0.0 2.4 8.4 0.0 3.3 4 0 0 4 4 4 0 PPR repeat IFRD PF05004.11 001301221.1_21025001_3 - 2.3e-111 371.6 3.5 2.8e-111 371.4 3.5 1.1 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) IFRD_C PF04836.10 001301221.1_21025001_3 - 3.6e-24 84.9 0.7 9.8e-24 83.6 0.7 1.8 1 0 0 1 1 1 1 Interferon-related protein conserved region HEAT PF02985.20 001301221.1_21025001_3 - 0.0068 16.4 0.5 21 5.6 0.0 4.4 4 0 0 4 4 4 1 HEAT repeat TGF_beta PF00019.18 001309396.1_21025001_1 - 6.8e-32 110.3 0.5 1.2e-31 109.6 0.5 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.16 001309396.1_21025001_1 - 6.4e-14 52.2 0.0 1e-13 51.5 0.0 1.2 1 0 0 1 1 1 1 TGF-beta propeptide KASH PF10541.7 001309396.1_21025001_2 - 0.012 15.7 3.9 0.026 14.6 3.9 1.5 1 0 0 1 1 1 0 Nuclear envelope localisation domain Arf PF00025.19 001242541.1_21022001_3 - 6.1e-79 263.4 0.1 7.9e-79 263.0 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001242541.1_21022001_3 - 2.4e-14 53.1 0.0 3.1e-14 52.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.11 001242541.1_21022001_3 - 1.2e-13 51.3 0.0 1.6e-13 50.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001242541.1_21022001_3 - 5.9e-12 45.3 0.0 7e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.18 001242541.1_21022001_3 - 9e-12 44.7 1.2 5.2e-08 32.3 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 001242541.1_21022001_3 - 1.6e-11 43.9 0.0 2.1e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001242541.1_21022001_3 - 3.1e-05 23.9 0.0 5e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.16 001242541.1_21022001_3 - 0.012 14.8 0.6 0.03 13.5 0.1 1.7 2 0 0 2 2 2 0 6-phosphofructo-2-kinase DUF258 PF03193.14 001242541.1_21022001_3 - 0.043 13.6 0.1 0.3 10.9 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Pilt PF15453.4 001192419.1_06526001_2 - 1.5e-75 254.8 26.9 3.8e-56 191.0 15.3 3.2 2 1 1 3 3 3 2 Protein incorporated later into Tight Junctions DUF2064 PF09837.7 001192419.1_06526001_2 - 0.046 13.4 0.0 0.091 12.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2064) IncA PF04156.12 001192419.1_06526001_2 - 0.058 13.0 14.0 0.11 12.2 14.0 1.3 1 0 0 1 1 1 0 IncA protein Spc7 PF08317.9 001192419.1_06526001_2 - 0.31 9.7 12.4 0.56 8.9 12.4 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein EzrA PF06160.10 001192419.1_06526001_2 - 0.35 8.9 8.7 0.5 8.4 8.7 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA GAS PF13851.4 001192419.1_06526001_2 - 0.49 9.6 13.9 0.96 8.6 13.9 1.4 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Uds1 PF15456.4 001192419.1_06526001_2 - 3.7 7.6 10.8 8.8 6.4 10.8 1.7 1 0 0 1 1 1 0 Up-regulated During Septation Exonuc_VII_L PF02601.13 001192419.1_06526001_2 - 4.7 6.5 7.5 7.1 6.0 7.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.4 001192419.1_06526001_2 - 5.2 6.2 6.2 7.7 5.6 6.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Atg14 PF10186.7 001192419.1_06526001_2 - 5.4 5.9 11.0 9.6 5.0 11.0 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Filament PF00038.19 001346176.1_21024001_2 - 2.9e-100 335.7 18.5 3.8e-100 335.3 18.5 1.1 1 0 0 1 1 1 1 Intermediate filament protein ATG16 PF08614.9 001346176.1_21024001_2 - 0.021 14.9 27.5 0.28 11.2 0.2 4.1 4 1 1 5 5 5 0 Autophagy protein 16 (ATG16) Gp58 PF07902.9 001346176.1_21024001_2 - 0.024 13.0 1.1 0.3 9.3 1.4 2.1 2 0 0 2 2 2 0 gp58-like protein TPR_MLP1_2 PF07926.10 001346176.1_21024001_2 - 0.095 12.6 29.0 0.085 12.8 2.3 3.7 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein OprB PF04966.10 001346176.1_21024001_2 - 0.16 11.2 3.5 3.3 6.9 0.4 2.9 1 1 2 3 3 3 0 Carbohydrate-selective porin, OprB family FlxA PF14282.4 001346176.1_21024001_2 - 0.92 9.4 18.2 0.83 9.5 10.3 3.7 2 2 1 3 3 3 0 FlxA-like protein V_ATPase_I PF01496.17 001346176.1_21024001_2 - 2.1 6.0 7.9 0.31 8.8 3.1 1.8 1 1 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF342 PF03961.11 001346176.1_21024001_2 - 2.8 6.3 10.7 2.4 6.5 6.5 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF342) Reo_sigmaC PF04582.10 001346176.1_21024001_2 - 3.1 7.0 12.2 0.36 10.1 2.4 2.7 2 1 0 3 3 3 0 Reovirus sigma C capsid protein IncA PF04156.12 001346176.1_21024001_2 - 3.5 7.3 24.6 1e+02 2.5 0.0 3.8 2 1 1 3 3 2 0 IncA protein DUF4446 PF14584.4 001346176.1_21024001_2 - 4.3 7.2 8.6 5.5 6.8 0.0 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF4446) SlyX PF04102.10 001346176.1_21024001_2 - 4.9 7.7 14.5 75 3.9 0.1 4.7 3 1 2 5 5 5 0 SlyX Bacillus_HBL PF05791.9 001346176.1_21024001_2 - 8.2 6.0 13.4 0.16 11.5 2.6 3.2 3 1 1 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) Filament PF00038.19 001346190.1_21024001_3 - 1.1e-97 327.2 16.7 1.5e-97 326.9 16.7 1.1 1 0 0 1 1 1 1 Intermediate filament protein Phage_Mu_Gam PF07352.10 001346190.1_21024001_3 - 0.0009 19.0 12.0 0.015 15.1 0.1 3.7 4 0 0 4 4 4 2 Bacteriophage Mu Gam like protein TPR_MLP1_2 PF07926.10 001346190.1_21024001_3 - 0.021 14.7 1.3 0.021 14.7 1.3 3.9 4 1 0 4 4 4 0 TPR/MLP1/MLP2-like protein Allexi_40kDa PF05549.9 001346190.1_21024001_3 - 2 7.8 6.3 0.58 9.5 2.0 2.2 2 0 0 2 2 2 0 Allexivirus 40kDa protein V_ATPase_I PF01496.17 001346190.1_21024001_3 - 3.7 5.2 8.3 0.59 7.8 3.7 1.7 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family FlxA PF14282.4 001346190.1_21024001_3 - 3.8 7.4 18.0 0.96 9.3 10.5 3.2 2 1 1 3 3 3 0 FlxA-like protein Reo_sigmaC PF04582.10 001346190.1_21024001_3 - 5.3 6.2 7.8 0.82 8.9 2.0 2.2 2 1 0 3 3 3 0 Reovirus sigma C capsid protein Filament PF00038.19 001346208.1_21025001_2 - 1e-116 389.8 36.6 1.2e-116 389.6 36.6 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001346208.1_21025001_2 - 3.4e-44 150.7 43.9 3.4e-44 150.7 43.9 3.2 2 1 0 2 2 1 1 Keratin type II head TPR_MLP1_2 PF07926.10 001346208.1_21025001_2 - 6.6e-06 26.1 29.4 0.0016 18.4 0.2 3.8 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein AAA_13 PF13166.4 001346208.1_21025001_2 - 2.7e-05 22.9 16.6 2.7e-05 22.9 16.6 1.5 1 1 0 1 1 1 1 AAA domain Spc7 PF08317.9 001346208.1_21025001_2 - 0.00079 18.3 32.6 0.0041 15.9 8.9 3.1 1 1 3 4 4 4 3 Spc7 kinetochore protein CENP-F_leu_zip PF10473.7 001346208.1_21025001_2 - 0.0015 18.4 26.0 0.0053 16.7 7.5 3.4 1 1 1 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.9 001346208.1_21025001_2 - 0.0031 17.6 25.8 0.13 12.3 3.5 2.7 1 1 0 2 2 2 2 Autophagy protein 16 (ATG16) Alanine_zipper PF11839.6 001346208.1_21025001_2 - 0.004 17.2 5.7 0.004 17.2 5.7 1.8 2 0 0 2 2 1 1 Alanine-zipper, major outer membrane lipoprotein Reo_sigmaC PF04582.10 001346208.1_21025001_2 - 0.053 12.8 4.8 0.61 9.3 0.4 2.6 1 1 2 3 3 3 0 Reovirus sigma C capsid protein Golgin_A5 PF09787.7 001346208.1_21025001_2 - 0.076 12.3 29.1 0.015 14.6 9.9 2.8 1 1 2 3 3 3 0 Golgin subfamily A member 5 Taxilin PF09728.7 001346208.1_21025001_2 - 0.11 11.6 28.0 0.96 8.5 28.1 2.3 1 1 0 1 1 1 0 Myosin-like coiled-coil protein Baculo_PEP_C PF04513.10 001346208.1_21025001_2 - 0.18 11.7 18.5 0.047 13.6 0.9 4.0 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF745 PF05335.11 001346208.1_21025001_2 - 0.3 10.7 16.0 0.33 10.6 10.8 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF745) Ax_dynein_light PF10211.7 001346208.1_21025001_2 - 0.33 10.8 27.6 0.45 10.3 8.4 3.0 1 1 2 3 3 3 0 Axonemal dynein light chain Lebercilin PF15619.4 001346208.1_21025001_2 - 0.54 9.7 30.8 0.075 12.5 13.8 2.7 1 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF5082 PF16888.3 001346208.1_21025001_2 - 0.71 10.1 23.2 0.84 9.9 0.9 4.0 1 1 2 4 4 4 0 Domain of unknown function (DUF5082) IncA PF04156.12 001346208.1_21025001_2 - 0.84 9.3 27.9 0.16 11.6 10.7 3.3 1 1 0 2 2 2 0 IncA protein DUF1451 PF07295.9 001346208.1_21025001_2 - 0.85 9.5 15.0 1.3 8.9 3.9 2.6 2 1 0 2 2 2 0 Zinc-ribbon containing domain DUF883 PF05957.11 001346208.1_21025001_2 - 0.97 9.9 16.4 1.4 9.4 5.5 3.7 3 1 1 4 4 3 0 Bacterial protein of unknown function (DUF883) ADIP PF11559.6 001346208.1_21025001_2 - 1.3 9.0 27.8 0.2 11.6 10.3 3.5 1 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding DUF948 PF06103.9 001346208.1_21025001_2 - 1.7 8.9 11.7 3.6 7.8 1.6 4.2 3 2 2 5 5 4 0 Bacterial protein of unknown function (DUF948) DUF3502 PF12010.6 001346208.1_21025001_2 - 1.8 9.1 5.1 2.5 8.6 2.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3502) ABC_tran_CTD PF16326.3 001346208.1_21025001_2 - 2.2 8.5 18.0 0.52 10.5 6.7 3.7 3 0 0 3 3 3 0 ABC transporter C-terminal domain COG5 PF10392.7 001346208.1_21025001_2 - 2.2 8.3 9.6 0.095 12.7 2.4 2.3 2 1 0 2 2 2 0 Golgi transport complex subunit 5 Tropomyosin_1 PF12718.5 001346208.1_21025001_2 - 2.3 8.2 28.7 0.045 13.7 11.2 3.6 2 1 1 4 4 4 0 Tropomyosin like WXG100 PF06013.10 001346208.1_21025001_2 - 2.6 8.2 7.7 40 4.4 5.2 3.7 2 1 0 2 2 2 0 Proteins of 100 residues with WXG DASH_Duo1 PF08651.8 001346208.1_21025001_2 - 2.7 7.7 9.1 2.5 7.8 0.9 3.8 4 1 0 4 4 4 0 DASH complex subunit Duo1 DUF1192 PF06698.9 001346208.1_21025001_2 - 2.9 7.9 5.8 1 9.3 0.2 2.9 3 1 0 3 3 2 0 Protein of unknown function (DUF1192) APG6 PF04111.10 001346208.1_21025001_2 - 3.6 6.8 32.2 0.11 11.7 9.6 3.0 1 1 2 3 3 3 0 Autophagy protein Apg6 DUF3584 PF12128.6 001346208.1_21025001_2 - 4.9 4.4 28.9 1.8 5.8 14.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) DUF4407 PF14362.4 001346208.1_21025001_2 - 5 6.3 22.2 9 5.4 4.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Tup_N PF08581.8 001346208.1_21025001_2 - 5.3 7.3 25.9 6.3 7.1 3.2 5.6 1 1 4 5 5 5 0 Tup N-terminal Jnk-SapK_ap_N PF09744.7 001346208.1_21025001_2 - 6.2 6.9 28.4 0.39 10.8 2.5 3.6 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 Cob_adeno_trans PF01923.16 001346208.1_21025001_2 - 7 6.6 8.8 14 5.6 6.5 2.4 1 1 1 2 2 2 0 Cobalamin adenosyltransferase JIP_LZII PF16471.3 001346208.1_21025001_2 - 8.2 6.6 15.3 1.1 9.3 0.1 4.7 4 1 1 5 5 4 0 JNK-interacting protein leucine zipper II DUF1664 PF07889.10 001346208.1_21025001_2 - 8.2 6.3 16.8 1.3 8.9 1.4 4.1 1 1 1 4 4 4 0 Protein of unknown function (DUF1664) ISG65-75 PF11727.6 001346208.1_21025001_2 - 8.3 5.4 11.2 1.2 8.2 5.6 2.1 2 0 0 2 2 2 0 Invariant surface glycoprotein Med9 PF07544.11 001346208.1_21025001_2 - 8.8 6.4 10.8 3.6 7.6 5.8 2.9 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 SlyX PF04102.10 001346208.1_21025001_2 - 9.1 6.9 20.4 0.11 13.0 1.3 4.3 3 1 1 4 4 3 0 SlyX MENTAL PF10457.7 001309289.1_21023001_2 - 1.4e-62 210.5 3.4 1.4e-62 210.5 3.4 1.6 2 0 0 2 2 2 1 Cholesterol-capturing domain Filament PF00038.19 001346138.1_21025001_3 - 1.5e-114 382.7 34.6 1.7e-114 382.5 34.6 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001346138.1_21025001_3 - 1.5e-39 135.6 45.0 1.5e-39 135.6 45.0 2.5 2 1 0 2 2 1 1 Keratin type II head TPR_MLP1_2 PF07926.10 001346138.1_21025001_3 - 5.6e-07 29.6 30.0 0.00011 22.1 1.2 3.7 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein Spc7 PF08317.9 001346138.1_21025001_3 - 0.00043 19.1 31.7 0.044 12.5 14.5 2.8 1 1 0 2 2 2 2 Spc7 kinetochore protein Gp58 PF07902.9 001346138.1_21025001_3 - 0.0008 17.8 8.9 0.0012 17.3 8.9 1.3 1 0 0 1 1 1 1 gp58-like protein AAA_13 PF13166.4 001346138.1_21025001_3 - 0.0023 16.6 19.8 0.0031 16.1 18.8 1.7 1 1 0 1 1 1 1 AAA domain Reo_sigmaC PF04582.10 001346138.1_21025001_3 - 0.0028 17.0 5.1 0.063 12.5 0.3 2.4 1 1 0 2 2 2 1 Reovirus sigma C capsid protein Alanine_zipper PF11839.6 001346138.1_21025001_3 - 0.0047 17.0 4.2 0.0047 17.0 4.2 2.2 2 0 0 2 2 2 1 Alanine-zipper, major outer membrane lipoprotein CENP-F_leu_zip PF10473.7 001346138.1_21025001_3 - 0.0069 16.3 23.7 0.015 15.2 5.3 3.2 1 1 2 4 4 4 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1192 PF06698.9 001346138.1_21025001_3 - 0.013 15.4 1.0 0.59 10.1 0.3 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1192) Jnk-SapK_ap_N PF09744.7 001346138.1_21025001_3 - 0.09 12.9 27.1 0.016 15.3 3.6 3.4 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 Virulence_fact PF13769.4 001346138.1_21025001_3 - 0.094 12.7 5.5 2.1 8.4 0.1 3.3 2 1 1 3 3 3 0 Virulence factor ADIP PF11559.6 001346138.1_21025001_3 - 0.14 12.1 24.6 0.016 15.2 5.9 3.4 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding UME PF08064.11 001346138.1_21025001_3 - 0.14 11.9 0.1 0.39 10.5 0.1 1.7 1 0 0 1 1 1 0 UME (NUC010) domain Golgin_A5 PF09787.7 001346138.1_21025001_3 - 0.16 11.3 27.1 0.033 13.5 8.6 2.8 1 1 3 4 4 4 0 Golgin subfamily A member 5 DUF745 PF05335.11 001346138.1_21025001_3 - 0.16 11.5 17.5 0.77 9.3 10.2 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF745) IncA PF04156.12 001346138.1_21025001_3 - 0.17 11.5 28.6 0.027 14.1 7.8 3.3 1 1 1 2 2 1 0 IncA protein UPF0184 PF03670.11 001346138.1_21025001_3 - 0.23 11.7 0.1 0.23 11.7 0.1 2.9 2 2 2 4 4 3 0 Uncharacterised protein family (UPF0184) DUF4407 PF14362.4 001346138.1_21025001_3 - 0.29 10.3 21.2 4.5e+02 -0.2 21.1 2.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.8 001346138.1_21025001_3 - 0.54 10.3 25.4 0.11 12.5 2.7 4.0 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family DUF883 PF05957.11 001346138.1_21025001_3 - 0.57 10.7 15.8 1.2 9.6 3.9 3.9 3 1 1 4 4 3 0 Bacterial protein of unknown function (DUF883) Baculo_PEP_C PF04513.10 001346138.1_21025001_3 - 0.88 9.5 19.0 0.62 10.0 1.8 3.8 1 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus LPP PF04728.11 001346138.1_21025001_3 - 0.98 9.7 9.8 1.1 9.6 0.3 4.4 4 1 1 5 5 4 0 Lipoprotein leucine-zipper Prominin PF05478.9 001346138.1_21025001_3 - 1.2 6.9 16.2 0.53 8.0 13.2 1.7 1 1 1 2 2 2 0 Prominin DASH_Duo1 PF08651.8 001346138.1_21025001_3 - 1.2 8.8 9.9 0.94 9.2 0.9 4.0 3 1 0 4 4 4 0 DASH complex subunit Duo1 APG6 PF04111.10 001346138.1_21025001_3 - 1.4 8.1 31.4 0.21 10.8 7.4 3.0 1 1 2 3 3 3 0 Autophagy protein Apg6 DUF1664 PF07889.10 001346138.1_21025001_3 - 1.8 8.4 16.7 1.5 8.7 1.4 4.0 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) DUF1451 PF07295.9 001346138.1_21025001_3 - 2.2 8.2 13.8 1.5 8.7 3.8 2.6 2 1 0 2 2 2 0 Zinc-ribbon containing domain Tropomyosin_1 PF12718.5 001346138.1_21025001_3 - 2.3 8.2 26.5 0.072 13.1 9.5 3.1 2 1 0 2 2 2 0 Tropomyosin like TMF_TATA_bd PF12325.6 001346138.1_21025001_3 - 2.4 8.3 25.2 3.1 7.9 0.7 4.0 1 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding CHDCT2 PF08074.9 001346138.1_21025001_3 - 3.2 7.8 13.1 4.6 7.3 1.1 2.7 1 1 0 2 2 2 0 CHDCT2 (NUC038) domain Rootletin PF15035.4 001346138.1_21025001_3 - 5.1 7.0 24.2 3.6 7.5 4.5 2.5 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion PRKG1_interact PF15898.3 001346138.1_21025001_3 - 6.2 7.7 23.1 6.7 7.6 1.8 3.7 2 2 1 3 3 3 0 cGMP-dependent protein kinase interacting domain DUF948 PF06103.9 001346138.1_21025001_3 - 8.1 6.6 11.6 7.7 6.7 0.9 4.1 3 2 4 7 7 6 0 Bacterial protein of unknown function (DUF948) Bap31 PF05529.10 001346138.1_21025001_3 - 8.5 5.8 21.9 0.034 13.6 3.9 3.2 1 1 2 3 3 3 0 B-cell receptor-associated protein 31-like DUF5082 PF16888.3 001346138.1_21025001_3 - 8.7 6.6 24.2 6.3 7.0 1.2 4.4 1 1 3 4 4 4 0 Domain of unknown function (DUF5082) V_ATPase_I PF01496.17 001346138.1_21025001_3 - 9 3.9 21.6 0.052 11.3 4.0 2.5 1 1 0 2 2 2 0 V-type ATPase 116kDa subunit family Ank_2 PF12796.5 001257187.1_21024001_1 - 1.3e-24 86.4 1.1 2.8e-14 53.3 0.1 2.5 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001257187.1_21024001_1 - 1.2e-18 67.1 0.1 9.5e-07 29.1 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 001257187.1_21024001_1 - 3.1e-15 55.7 0.2 4.3e-06 26.8 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.4 001257187.1_21024001_1 - 2.6e-12 46.6 0.2 3.2e-05 24.1 0.0 3.5 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 001257187.1_21024001_1 - 3.5e-11 42.2 0.0 0.00026 21.0 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat Filament PF00038.19 001346212.1_21024001_3 - 9.5e-113 376.7 31.5 1.1e-112 376.5 31.5 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001346212.1_21024001_3 - 7.9e-12 45.5 24.4 2.1e-10 40.9 0.4 3.2 2 1 1 3 3 3 2 Keratin type II head Spc7 PF08317.9 001346212.1_21024001_3 - 0.00026 19.9 6.3 0.00026 19.9 6.3 3.8 1 1 2 4 4 4 2 Spc7 kinetochore protein TPR_MLP1_2 PF07926.10 001346212.1_21024001_3 - 0.0011 18.9 32.5 0.0015 18.5 0.1 3.8 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.7 001346212.1_21024001_3 - 0.0011 18.9 23.7 0.014 15.2 8.0 3.3 1 1 2 4 4 4 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TSNAXIP1_N PF15739.3 001346212.1_21024001_3 - 0.0037 17.5 0.6 0.0037 17.5 0.6 3.8 3 1 1 4 4 4 1 Translin-associated factor X-interacting N-terminus DUF5082 PF16888.3 001346212.1_21024001_3 - 0.012 15.8 20.1 0.056 13.7 0.5 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF5082) She9_MDM33 PF05546.9 001346212.1_21024001_3 - 0.022 14.5 8.8 1.5 8.5 5.2 2.5 2 0 0 2 2 2 0 She9 / Mdm33 family Prefoldin PF02996.15 001346212.1_21024001_3 - 0.11 12.3 0.2 0.11 12.3 0.2 4.5 4 2 1 6 6 6 0 Prefoldin subunit Reo_sigmaC PF04582.10 001346212.1_21024001_3 - 0.21 10.8 4.0 7.4 5.7 0.2 2.5 1 1 2 3 3 3 0 Reovirus sigma C capsid protein Jnk-SapK_ap_N PF09744.7 001346212.1_21024001_3 - 0.22 11.6 27.2 0.62 10.1 2.7 3.3 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 APG6 PF04111.10 001346212.1_21024001_3 - 0.41 9.9 25.4 0.28 10.4 11.6 2.4 2 0 0 2 2 2 0 Autophagy protein Apg6 Ribosomal_S30AE PF02482.17 001346212.1_21024001_3 - 0.75 10.5 6.2 0.33 11.6 2.4 2.4 2 1 1 3 3 2 0 Sigma 54 modulation protein / S30EA ribosomal protein AAA_13 PF13166.4 001346212.1_21024001_3 - 0.83 8.1 21.0 0.11 11.0 16.1 1.9 1 1 0 1 1 1 0 AAA domain CALCOCO1 PF07888.9 001346212.1_21024001_3 - 1 7.7 29.6 1 7.7 12.0 2.0 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Rootletin PF15035.4 001346212.1_21024001_3 - 1.6 8.6 21.6 1.8 8.5 6.6 2.8 2 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion ATG16 PF08614.9 001346212.1_21024001_3 - 1.8 8.6 29.5 0.41 10.7 4.3 3.4 1 1 1 3 3 3 0 Autophagy protein 16 (ATG16) Fez1 PF06818.13 001346212.1_21024001_3 - 2.3 8.5 24.5 26 5.0 18.8 2.6 1 1 1 2 2 2 0 Fez1 IncA PF04156.12 001346212.1_21024001_3 - 2.8 7.6 30.4 1.4 8.6 7.0 3.3 1 1 2 3 3 3 0 IncA protein JAKMIP_CC3 PF16034.3 001346212.1_21024001_3 - 3.9 7.2 26.9 0.13 12.0 9.6 3.4 2 1 1 3 3 3 0 JAKMIP CC3 domain Alanine_zipper PF11839.6 001346212.1_21024001_3 - 7.1 6.9 17.3 1.9 8.7 13.6 2.0 2 0 0 2 2 1 0 Alanine-zipper, major outer membrane lipoprotein DUF1451 PF07295.9 001346212.1_21024001_3 - 7.6 6.4 13.8 3.1 7.7 1.9 2.7 2 0 0 2 2 2 0 Zinc-ribbon containing domain LPP PF04728.11 001346212.1_21024001_3 - 8.7 6.7 13.0 0.62 10.4 0.5 4.5 5 1 0 5 5 4 0 Lipoprotein leucine-zipper RnaseA PF00074.18 001309412.1_21021001_1 - 9.8e-45 151.9 10.1 1.1e-44 151.7 10.1 1.0 1 0 0 1 1 1 1 Pancreatic ribonuclease TNF PF00229.16 001205161.1_21025001_1 - 2e-10 40.5 0.0 3.3e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family DUF1049 PF06305.9 001205161.1_21025001_1 - 0.13 11.9 1.0 0.26 11.0 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) V1R PF03402.12 001167531.1_21022001_1 - 6.2e-33 114.4 16.2 8.1e-33 114.0 16.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R Glu_cys_ligase PF04262.12 001167531.1_21022001_1 - 0.5 8.8 5.4 0.054 12.0 1.1 1.5 2 0 0 2 2 2 0 Glutamate-cysteine ligase Ion_trans PF00520.29 001193658.2_21028001_2 - 1.9e-35 122.1 2.9 2.7e-35 121.7 2.9 1.2 1 0 0 1 1 1 1 Ion transport protein PAS_9 PF13426.5 001193658.2_21028001_2 - 5.1e-17 61.9 0.0 1e-16 60.9 0.0 1.4 1 0 0 1 1 1 1 PAS domain Ion_trans_2 PF07885.14 001193658.2_21028001_2 - 5.6e-12 45.3 0.3 2.2e-11 43.5 0.3 2.0 1 0 0 1 1 1 1 Ion channel cNMP_binding PF00027.27 001193658.2_21028001_2 - 8.5e-12 44.8 0.0 2.2e-11 43.5 0.0 1.8 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain PAS PF00989.23 001193658.2_21028001_2 - 1.7e-09 37.5 0.0 5.6e-09 35.9 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.10 001193658.2_21028001_2 - 2.2e-06 27.7 0.0 4.5e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.8 001193658.2_21028001_2 - 7.6e-05 22.8 0.0 0.0009 19.3 0.0 2.6 3 0 0 3 3 3 1 PAS fold PAS_8 PF13188.5 001193658.2_21028001_2 - 0.0075 16.1 0.0 0.021 14.7 0.0 1.8 1 0 0 1 1 1 1 PAS domain Pkinase_Tyr PF07714.15 001309471.1_21029001_3 - 1.8e-104 348.5 0.0 2.4e-104 348.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.4 001309471.1_21029001_3 - 4.7e-59 196.8 11.3 7.9e-15 55.1 0.0 7.7 7 0 0 7 7 7 6 Immunoglobulin domain I-set PF07679.14 001309471.1_21029001_3 - 5.4e-57 189.7 2.5 6.6e-18 64.4 0.0 7.8 7 1 0 7 7 7 6 Immunoglobulin I-set domain Pkinase PF00069.23 001309471.1_21029001_3 - 1.3e-44 152.4 0.0 5.4e-31 107.8 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Ig_2 PF13895.4 001309471.1_21029001_3 - 3.5e-40 136.1 18.0 5.6e-14 52.1 0.1 8.3 7 1 0 7 7 7 6 Immunoglobulin domain ig PF00047.23 001309471.1_21029001_3 - 4.4e-40 135.6 20.9 1.2e-11 44.4 0.1 8.6 8 1 0 8 8 7 5 Immunoglobulin domain V-set PF07686.15 001309471.1_21029001_3 - 2.7e-22 78.8 16.1 2.2e-05 24.4 0.1 8.6 7 3 0 7 7 6 4 Immunoglobulin V-set domain C1-set PF07654.13 001309471.1_21029001_3 - 2e-09 37.7 8.7 0.0032 17.8 0.1 5.2 5 0 0 5 5 5 3 Immunoglobulin C1-set domain Izumo-Ig PF16706.3 001309471.1_21029001_3 - 1.8e-05 24.5 1.0 5.9 6.9 0.0 5.7 6 0 0 6 6 6 1 Izumo-like Immunoglobulin domain Ig_4 PF16680.3 001309471.1_21029001_3 - 6.7e-05 23.0 4.4 0.14 12.4 0.0 5.7 5 0 0 5 5 5 1 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.3 001309471.1_21029001_3 - 0.0072 16.6 13.8 0.049 13.9 0.0 5.7 6 1 0 6 6 5 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set PF05790.13 001309471.1_21029001_3 - 0.024 14.7 0.0 33 4.6 0.0 4.9 5 0 0 5 5 5 0 Immunoglobulin C2-set domain Herpes_gE PF02480.14 001309471.1_21029001_3 - 0.08 11.5 0.1 1.8 7.1 0.0 2.4 3 0 0 3 3 3 0 Alphaherpesvirus glycoprotein E C2-set_2 PF08205.10 001309471.1_21029001_3 - 0.093 12.7 0.5 1.4 8.9 0.0 3.1 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain Cyclin_N PF00134.21 001281817.1_21029001_3 - 4.5e-38 129.8 5.7 7.9e-38 129.0 2.2 2.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 001281817.1_21029001_3 - 9.9e-24 83.6 1.0 2.4e-23 82.3 1.0 1.7 1 0 0 1 1 1 1 Cyclin, C-terminal domain Fn3_assoc PF13287.4 001281817.1_21029001_3 - 2.3 8.3 5.1 20 5.3 0.2 4.4 4 0 0 4 4 4 0 Fn3 associated Cadherin PF00028.15 001109812.1_21025001_3 - 1.2e-82 272.3 4.1 2.9e-18 65.9 0.0 5.6 6 0 0 6 6 6 5 Cadherin domain Cadherin_pro PF08758.9 001109812.1_21025001_3 - 2.1e-26 91.7 0.1 2.6e-25 88.2 0.0 2.6 3 0 0 3 3 3 1 Cadherin prodomain like Cadherin_2 PF08266.10 001109812.1_21025001_3 - 0.013 15.2 0.0 0.45 10.2 0.0 3.0 3 0 0 3 3 3 0 Cadherin-like Cu-binding_MopE PF11617.6 001109812.1_21025001_3 - 0.022 14.8 0.4 0.069 13.2 0.4 1.9 1 0 0 1 1 1 0 Putative metal-binding motif CC2-LZ PF16516.3 001284533.1_21023001_1 - 7.9e-30 103.1 18.8 7.9e-30 103.1 18.8 3.8 1 1 2 3 3 3 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator NEMO PF11577.6 001284533.1_21023001_1 - 5.8e-27 93.4 13.5 5.8e-27 93.4 13.5 4.9 4 2 2 6 6 6 1 NF-kappa-B essential modulator NEMO Golgin_A5 PF09787.7 001284533.1_21023001_1 - 0.14 11.5 71.8 0.18 11.1 19.2 3.1 1 1 2 3 3 3 0 Golgin subfamily A member 5 Filament PF00038.19 001284533.1_21023001_1 - 0.23 10.9 57.4 0.35 10.3 57.4 1.4 1 0 0 1 1 1 0 Intermediate filament protein GAS PF13851.4 001284533.1_21023001_1 - 6.4 6.0 69.5 2.1 7.5 20.0 4.2 1 1 3 4 4 4 0 Growth-arrest specific micro-tubule binding LLC1 PF14945.4 001284533.1_21023001_1 - 8.3 6.9 12.1 0.16 12.4 0.6 3.3 1 1 3 4 4 4 0 Normal lung function maintenance, Low in Lung Cancer 1 protein Motilin_ghrelin PF04644.10 001163967.1_21021001_1 - 1.2e-16 60.1 1.0 1.9e-16 59.4 1.0 1.3 1 0 0 1 1 1 1 Motilin/ghrelin Motilin_assoc PF04643.10 001163967.1_21021001_1 - 2.7e-13 49.4 0.1 4.3e-13 48.8 0.1 1.3 1 0 0 1 1 1 1 Motilin/ghrelin-associated peptide Carb_anhydrase PF00194.19 001080908.3_06527001_2 - 7.9e-86 287.6 0.0 1e-85 287.2 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Asp_protease_2 PF13650.4 001172559.1_21029001_2 - 0.00069 20.1 0.0 0.0012 19.3 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001172559.1_21029001_2 - 0.038 13.8 0.0 0.07 13.0 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001172559.1_21029001_2 - 0.061 13.7 0.0 0.11 12.9 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Retrotrans_gag PF03732.15 001172559.1_21029001_3 - 3.9e-15 55.8 2.0 1.1e-14 54.3 0.1 2.3 2 0 0 2 2 2 1 Retrotransposon gag protein DUF4939 PF16297.3 001172559.1_21029001_3 - 5.2e-15 55.2 0.0 1.2e-14 54.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) KASH_CCD PF14662.4 001172559.1_21029001_3 - 0.0019 17.9 1.8 0.0032 17.2 1.8 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH zf-CCHC_5 PF14787.4 001172559.1_21029001_3 - 0.0024 17.4 0.2 0.0058 16.2 0.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger Rootletin PF15035.4 001172559.1_21029001_3 - 0.0058 16.6 3.3 0.011 15.7 3.3 1.4 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion bZIP_1 PF00170.19 001172559.1_21029001_3 - 0.044 13.8 1.5 0.16 12.0 1.5 2.0 1 0 0 1 1 1 0 bZIP transcription factor SHE3 PF17078.3 001172559.1_21029001_3 - 0.11 12.0 2.7 0.22 11.1 2.7 1.3 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 ZapB PF06005.10 001172559.1_21029001_3 - 0.13 12.6 5.9 0.29 11.5 5.9 1.5 1 0 0 1 1 1 0 Cell division protein ZapB DUF3450 PF11932.6 001172559.1_21029001_3 - 0.21 10.7 0.7 0.33 10.1 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) TMF_DNA_bd PF12329.6 001172559.1_21029001_3 - 0.39 10.6 3.9 0.7 9.8 3.9 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF972 PF06156.11 001172559.1_21029001_3 - 0.39 11.2 2.4 0.88 10.1 2.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Spc7 PF08317.9 001172559.1_21029001_3 - 0.72 8.5 3.2 1.2 7.8 3.2 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein CENP-H PF05837.10 001172559.1_21029001_3 - 1.1 9.6 3.9 2.9 8.2 3.9 1.6 1 0 0 1 1 1 0 Centromere protein H (CENP-H) zf-CCHC PF00098.21 001172559.1_21029001_3 - 1.3 9.1 7.2 0.34 10.9 2.2 2.5 2 0 0 2 2 2 0 Zinc knuckle IncA PF04156.12 001172559.1_21029001_3 - 1.4 8.5 3.9 2.5 7.7 3.9 1.3 1 0 0 1 1 1 0 IncA protein DivIC PF04977.13 001172559.1_21029001_3 - 1.9 8.2 3.8 4.6 7.0 3.8 1.6 1 0 0 1 1 1 0 Septum formation initiator V1R PF03402.12 001167170.1_21023001_1 - 2.1e-25 89.7 16.8 3.5e-25 89.0 16.8 1.3 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167170.1_21023001_1 - 4.5e-08 32.4 22.2 5.4e-08 32.2 22.2 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167170.1_21023001_1 - 1.7e-05 24.1 14.6 2.1e-05 23.7 14.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CDP-OH_P_transf PF01066.19 001309181.1_21024001_1 - 1.7e-17 63.8 0.1 1.7e-17 63.8 0.1 3.3 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase FAST_1 PF06743.13 001256937.1_21026001_1 - 1.6e-21 75.9 1.9 3.7e-20 71.5 0.1 2.8 2 0 0 2 2 2 1 FAST kinase-like protein, subdomain 1 FAST_2 PF08368.10 001256937.1_21026001_1 - 2.8e-19 69.6 0.1 6.9e-19 68.3 0.1 1.7 1 0 0 1 1 1 1 FAST kinase-like protein, subdomain 2 RAP PF08373.8 001256937.1_21026001_1 - 3e-11 43.1 0.8 5.6e-11 42.2 0.8 1.5 1 0 0 1 1 1 1 RAP domain NAP PF00956.16 001257182.1_21023001_1 - 4.9e-96 320.9 5.4 2.9e-95 318.4 5.4 1.9 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) DUF4632 PF15451.4 001257182.1_21023001_1 - 0.14 12.1 2.4 0.55 10.2 2.4 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4632) DUF4713 PF15831.3 001163001.1_06521001_1 - 5.1e-06 26.7 0.1 8.2e-06 26.0 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4713) IRK PF01007.18 001193254.1_06523001_2 - 3.4e-86 289.0 0.0 4.4e-86 288.7 0.0 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 001193254.1_06523001_2 - 4.8e-05 23.1 1.2 4.8e-05 23.1 1.2 1.8 2 0 0 2 2 2 1 Ion channel DUF3324 PF11797.6 001193254.1_06523001_2 - 0.18 11.6 0.0 0.44 10.4 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function C-terminal (DUF3324) V1R PF03402.12 001167530.1_21022001_1 - 8.8e-44 150.0 15.6 1e-43 149.8 15.6 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167530.1_21022001_1 - 5.4e-06 25.6 18.5 7.2e-06 25.2 18.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167530.1_21022001_1 - 0.0053 15.9 15.7 0.016 14.3 15.7 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRRFIP PF09738.7 001308938.1_21023001_1 - 3.5e-109 364.7 23.1 3.5e-109 364.7 23.1 2.0 2 0 0 2 2 2 1 LRRFIP family DUF1664 PF07889.10 001308938.1_21023001_1 - 0.0048 16.7 25.7 0.72 9.7 2.7 4.3 2 1 2 4 4 4 3 Protein of unknown function (DUF1664) TACC PF05010.12 001308938.1_21023001_1 - 0.01 15.5 10.7 0.01 15.5 10.7 3.7 4 0 0 4 4 4 0 Transforming acidic coiled-coil-containing protein (TACC) KASH_CCD PF14662.4 001308938.1_21023001_1 - 0.015 15.0 13.8 0.015 15.0 13.8 4.1 3 1 1 4 4 4 0 Coiled-coil region of CCDC155 or KASH Reo_sigmaC PF04582.10 001308938.1_21023001_1 - 0.06 12.6 7.6 1.6 7.9 0.5 2.9 2 1 0 3 3 3 0 Reovirus sigma C capsid protein NPV_P10 PF05531.10 001308938.1_21023001_1 - 0.06 13.7 0.8 0.06 13.7 0.8 3.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF724 PF05266.12 001308938.1_21023001_1 - 0.33 10.6 41.6 0.024 14.3 8.9 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF724) AAA_13 PF13166.4 001308938.1_21023001_1 - 0.44 9.0 29.2 0.032 12.8 7.5 2.7 3 0 0 3 3 3 0 AAA domain DUF16 PF01519.14 001308938.1_21023001_1 - 2 8.8 28.4 1.9 8.9 5.5 3.9 3 1 1 4 4 4 0 Protein of unknown function DUF16 Syntaxin-6_N PF09177.9 001308938.1_21023001_1 - 2.3 8.7 24.2 0.21 12.1 5.2 4.0 2 2 1 3 3 3 0 Syntaxin 6, N-terminal LMBR1 PF04791.14 001308938.1_21023001_1 - 2.4 6.8 16.5 2.5 6.8 0.9 2.1 2 0 0 2 2 2 0 LMBR1-like membrane protein FAM76 PF16046.3 001308938.1_21023001_1 - 3.1 6.9 30.7 2 7.6 14.1 2.3 2 0 0 2 2 2 0 FAM76 protein V_ATPase_I PF01496.17 001308938.1_21023001_1 - 4.1 5.0 22.6 0.86 7.3 6.1 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Laminin_II PF06009.10 001308938.1_21023001_1 - 4.7 7.1 30.7 0.02 14.8 8.1 4.0 4 1 0 4 4 4 0 Laminin Domain II Prominin PF05478.9 001308938.1_21023001_1 - 5.6 4.6 12.8 0.67 7.7 2.0 2.2 2 0 0 2 2 2 0 Prominin DUF3584 PF12128.6 001308938.1_21023001_1 - 5.9 4.1 39.7 0.18 9.1 5.4 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3584) CALCOCO1 PF07888.9 001308938.1_21023001_1 - 9.2 4.6 44.5 0.22 9.9 8.8 3.1 3 0 0 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like XPG_N PF00752.15 001257085.1_21024001_3 - 4.1e-37 126.6 0.0 7.5e-37 125.7 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.16 001257085.1_21024001_3 - 2.8e-30 104.4 0.0 5.3e-30 103.5 0.0 1.5 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.18 001257085.1_21024001_3 - 4.1e-07 30.4 0.0 1e-06 29.1 0.0 1.7 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.4 001257085.1_21024001_3 - 0.067 13.7 0.0 0.15 12.6 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain EF-hand_7 PF13499.4 001309291.1_21024001_3 - 9.3e-11 41.9 3.4 9.3e-11 41.9 3.4 4.1 3 2 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.30 001309291.1_21024001_3 - 7.8e-09 34.3 1.1 0.0014 17.9 0.3 3.2 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 001309291.1_21024001_3 - 1.5e-07 30.6 0.6 9.2e-05 22.0 0.2 3.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.4 001309291.1_21024001_3 - 0.00067 18.9 1.6 0.048 13.1 0.3 3.6 3 0 0 3 3 3 1 EF hand Macoilin PF09726.7 001309291.1_21024001_3 - 0.074 11.5 20.9 0.11 10.9 20.9 1.2 1 0 0 1 1 1 0 Transmembrane protein Put_DNA-bind_N PF06971.11 001309291.1_21024001_3 - 0.79 9.6 0.0 0.79 9.6 0.0 2.5 3 0 0 3 3 3 0 Putative DNA-binding protein N-terminus Vma12 PF11712.6 001309291.1_21024001_3 - 2.4 8.1 12.5 6.4 6.7 2.8 2.7 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase KfrA_N PF11740.6 001309291.1_21024001_3 - 9 6.9 13.1 12 6.5 9.8 2.6 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term AIRS_C PF02769.20 001190419.1_21026001_3 - 3.3e-30 105.2 0.1 4.5e-30 104.7 0.1 1.2 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.22 001190419.1_21026001_3 - 4.5e-10 39.9 0.3 9.1e-10 38.9 0.3 1.4 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain HGAL PF15666.3 001191208.1_06522001_2 - 8.4e-41 137.8 0.5 1.4e-40 137.1 0.5 1.3 1 0 0 1 1 1 1 Germinal center-associated lymphoma NUC153 PF08159.10 001301273.1_21027001_1 - 8.3e-12 44.6 1.1 8.3e-12 44.6 1.1 3.5 3 0 0 3 3 3 2 NUC153 domain Fun_ATP-synt_8 PF05933.11 001163117.2_21029001_1 - 4 7.5 6.4 10 6.3 6.4 1.6 1 0 0 1 1 1 0 Fungal ATP synthase protein 8 (A6L) TSP_C PF05735.10 001163117.2_21029001_2 - 6.2e-96 319.9 2.9 8.9e-96 319.4 2.9 1.2 1 0 0 1 1 1 1 Thrombospondin C-terminal region TSP_3 PF02412.16 001163117.2_21029001_2 - 7.5e-57 188.6 138.4 1.1e-10 40.9 15.1 9.9 7 2 2 9 9 9 8 Thrombospondin type 3 repeat TSP_1 PF00090.17 001163117.2_21029001_2 - 4.4e-41 138.7 56.9 8e-16 57.9 10.5 4.4 4 0 0 4 4 4 3 Thrombospondin type 1 domain VWC PF00093.16 001163117.2_21029001_2 - 1.3e-12 47.7 18.2 1.3e-12 47.7 18.2 5.0 4 1 1 5 5 5 1 von Willebrand factor type C domain EGF_3 PF12947.5 001163117.2_21029001_2 - 9.9e-08 31.9 7.5 9.9e-08 31.9 7.5 5.3 6 0 0 6 6 6 2 EGF domain EGF_CA PF07645.13 001163117.2_21029001_2 - 1.7e-06 28.0 1.5 1.7e-06 28.0 1.5 5.2 4 0 0 4 4 4 2 Calcium-binding EGF domain EGF PF00008.25 001163117.2_21029001_2 - 0.00023 21.3 9.0 0.00023 21.3 9.0 4.9 4 0 0 4 4 4 1 EGF-like domain cEGF PF12662.5 001163117.2_21029001_2 - 0.0034 17.2 0.5 0.0034 17.2 0.5 4.6 4 0 0 4 4 4 2 Complement Clr-like EGF-like Laminin_G_3 PF13385.4 001163117.2_21029001_2 - 0.018 15.0 1.1 0.31 11.0 0.0 2.3 2 0 0 2 2 2 0 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.22 001163117.2_21029001_2 - 0.02 15.3 0.0 0.039 14.4 0.0 1.4 1 0 0 1 1 1 0 Laminin G domain Nramp PF01566.16 001081857.2_21024001_3 - 1.2e-116 389.5 12.0 1.2e-116 389.5 12.0 1.5 2 0 0 2 2 2 1 Natural resistance-associated macrophage protein Peptidase_C14 PF00656.20 001163961.1_21022001_2 - 1.6e-53 182.1 0.1 2e-53 181.8 0.1 1.1 1 0 0 1 1 1 1 Caspase domain DUF4939 PF16297.3 001195020.1_06528001_1 - 2.8e-13 49.6 0.0 5.9e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Retrotrans_gag PF03732.15 001195020.1_06528001_1 - 4.4e-10 39.6 0.0 1.9e-09 37.5 0.0 2.2 1 0 0 1 1 1 1 Retrotransposon gag protein gag-asp_proteas PF13975.4 001195020.1_06528001_1 - 2.1e-05 24.8 0.0 6.7e-05 23.2 0.0 1.8 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.4 001195020.1_06528001_1 - 0.00037 21.0 0.0 0.00086 19.8 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001195020.1_06528001_1 - 0.0087 15.9 0.0 0.018 14.9 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease RVT_1 PF00078.25 001195020.1_06528001_1 - 0.038 13.4 0.0 0.077 12.4 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) UCH PF00443.27 001257076.1_21026001_1 - 1.4e-51 175.3 1.2 2.6e-51 174.5 1.2 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_N PF16674.3 001257076.1_21026001_1 - 1.2e-38 131.2 1.4 1.2e-38 131.2 1.4 2.8 3 0 0 3 3 3 1 N-terminal of ubiquitin carboxyl-terminal hydrolase 37 UCH_1 PF13423.4 001257076.1_21026001_1 - 1.7e-17 63.9 14.1 2.9e-14 53.3 3.4 2.9 2 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Zn-ribbon_8 PF09723.8 001257076.1_21026001_1 - 0.12 12.3 0.5 4.8 7.3 0.1 2.9 2 0 0 2 2 2 0 Zinc ribbon domain HEAT_2 PF13646.4 001308283.1_21029001_2 - 4e-09 36.6 12.4 0.35 11.2 0.1 8.7 6 2 2 8 8 8 4 HEAT repeats HEAT PF02985.20 001308283.1_21029001_2 - 1.8e-06 27.6 33.0 0.14 12.4 0.7 9.6 10 0 0 10 10 10 4 HEAT repeat Vac14_Fab1_bd PF12755.5 001308283.1_21029001_2 - 0.0026 18.2 0.1 0.036 14.5 0.1 2.9 2 0 0 2 2 2 1 Vacuolar 14 Fab1-binding region UME PF08064.11 001308283.1_21029001_2 - 0.013 15.3 5.9 2.5 8.0 0.0 5.0 5 0 0 5 5 5 0 UME (NUC010) domain Cnd1 PF12717.5 001308283.1_21029001_2 - 0.075 12.9 7.2 4.3 7.2 0.1 5.3 6 1 0 7 7 7 0 non-SMC mitotic condensation complex subunit 1 7tm_1 PF00001.19 001257078.1_21023001_1 - 2.3e-47 161.4 31.9 7e-47 159.8 31.9 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ion_trans PF00520.29 001256931.1_21024001_1 - 5.2e-51 173.1 13.1 7.1e-51 172.7 13.1 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 001256931.1_21024001_1 - 8.2e-29 99.7 0.3 1.8e-28 98.6 0.0 1.7 2 0 0 2 2 2 1 BTB/POZ domain Ion_trans_2 PF07885.14 001256931.1_21024001_1 - 5.7e-14 51.7 5.3 5.7e-14 51.7 5.3 2.8 3 0 0 3 3 3 1 Ion channel PKD_channel PF08016.10 001256931.1_21024001_1 - 0.0028 16.3 0.8 0.0028 16.3 0.8 1.6 1 1 0 1 1 1 1 Polycystin cation channel Sigma_reg_N PF13800.4 001256931.1_21024001_1 - 0.045 13.9 5.0 2.6 8.3 0.1 3.7 4 0 0 4 4 4 0 Sigma factor regulator N-terminal DUF423 PF04241.13 001256931.1_21024001_1 - 4 7.6 4.7 1.1 9.3 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF423) Alpha_kinase PF02816.16 001192542.1_06526001_2 - 2.8e-55 187.3 0.0 5e-55 186.5 0.0 1.4 1 0 0 1 1 1 1 Alpha-kinase family Sel1 PF08238.10 001192542.1_06526001_2 - 9e-08 32.4 5.1 0.07 13.7 0.0 5.2 5 0 0 5 5 5 3 Sel1 repeat p450 PF00067.20 001190940.1_21024001_1 - 2.5e-127 425.3 0.5 2.9e-127 425.1 0.5 1.0 1 0 0 1 1 1 1 Cytochrome P450 OCIA PF07051.9 001190940.1_21024001_1 - 0.15 12.0 0.2 0.46 10.4 0.2 1.8 1 0 0 1 1 1 0 Ovarian carcinoma immunoreactive antigen (OCIA) Defensin_propep PF00879.16 001166086.1_21021001_1 - 3.3e-20 72.0 3.9 4.3e-20 71.6 3.9 1.1 1 0 0 1 1 1 1 Defensin propeptide Defensin_beta PF00711.17 001166086.1_21021001_1 - 3.9 7.4 12.2 6.1 6.8 12.2 1.3 1 0 0 1 1 1 0 Beta defensin Rep_fac_C PF08542.9 001309197.1_21024001_1 - 1.1e-24 86.5 0.2 1.4e-23 82.9 0.1 2.3 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA PF00004.27 001309197.1_21024001_1 - 1.9e-15 57.3 0.0 3.3e-15 56.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.4 001309197.1_21024001_1 - 5.9e-14 52.0 0.0 1.3e-10 41.2 0.0 2.2 1 1 1 2 2 2 2 DNA polymerase III, delta subunit Rad17 PF03215.13 001309197.1_21024001_1 - 1.3e-11 44.0 0.0 4.9e-08 32.2 0.0 2.1 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_24 PF13479.4 001309197.1_21024001_1 - 2.8e-06 27.1 0.0 5.1e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.3 001309197.1_21024001_1 - 3.6e-06 27.0 0.0 7.5e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 AAA C-terminal domain AAA_16 PF13191.4 001309197.1_21024001_1 - 1.2e-05 25.6 0.0 2.2e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_11 PF13086.4 001309197.1_21024001_1 - 2.6e-05 24.0 0.0 0.00024 20.8 0.0 2.0 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.10 001309197.1_21024001_1 - 3.5e-05 23.1 0.0 7.4e-05 22.0 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.4 001309197.1_21024001_1 - 6.4e-05 23.1 0.4 0.026 14.7 0.2 2.8 2 1 0 2 2 1 1 AAA domain DUF815 PF05673.11 001309197.1_21024001_1 - 0.00049 19.2 0.0 0.00083 18.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ResIII PF04851.13 001309197.1_21024001_1 - 0.00056 19.8 0.0 0.07 13.0 0.0 2.2 1 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.4 001309197.1_21024001_1 - 0.0017 18.6 0.5 0.039 14.2 0.0 2.6 2 1 1 3 3 3 1 AAA domain AAA_14 PF13173.4 001309197.1_21024001_1 - 0.0019 18.1 0.0 0.0032 17.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.11 001309197.1_21024001_1 - 0.0022 16.9 0.0 0.023 13.5 0.0 2.0 2 0 0 2 2 2 1 TIP49 C-terminus AAA_5 PF07728.12 001309197.1_21024001_1 - 0.003 17.4 0.1 0.018 14.9 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DNA_pol3_delta PF06144.11 001309197.1_21024001_1 - 0.0038 16.9 0.0 0.0075 15.9 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit DEAD PF00270.27 001309197.1_21024001_1 - 0.0047 16.6 0.1 0.082 12.5 0.0 2.2 1 1 1 2 2 2 1 DEAD/DEAH box helicase PhoH PF02562.14 001309197.1_21024001_1 - 0.0073 15.6 0.1 0.13 11.6 0.0 2.2 1 1 0 2 2 2 1 PhoH-like protein AAA_30 PF13604.4 001309197.1_21024001_1 - 0.0082 15.7 0.0 0.087 12.4 0.0 2.2 1 1 0 1 1 1 1 AAA domain TniB PF05621.9 001309197.1_21024001_1 - 0.02 13.9 0.0 0.12 11.4 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein IstB_IS21 PF01695.15 001309197.1_21024001_1 - 0.059 13.0 0.1 0.39 10.3 0.1 2.1 1 1 0 1 1 1 0 IstB-like ATP binding protein T2SSE PF00437.18 001309197.1_21024001_1 - 0.063 12.2 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase_2 PF01637.16 001309197.1_21024001_1 - 0.098 12.4 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Mg_chelatase PF01078.19 001309197.1_21024001_1 - 0.17 11.1 0.1 1.2 8.3 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI SGL PF08450.10 001242448.1_21022001_1 - 5.6e-78 261.8 0.1 6.4e-78 261.6 0.1 1.0 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region NHL PF01436.19 001242448.1_21022001_1 - 0.033 14.1 0.0 0.075 13.0 0.0 1.7 1 0 0 1 1 1 0 NHL repeat Reg_prop PF07494.9 001242448.1_21022001_1 - 0.045 13.9 0.0 0.28 11.4 0.0 2.4 2 1 0 2 2 2 0 Two component regulator propeller Acyl-CoA_dh_C PF12806.5 001242448.1_21022001_1 - 0.13 12.3 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 Acetyl-CoA dehydrogenase C-terminal like Peptidase_C13 PF01650.16 001309321.1_21024001_2 - 9.4e-44 149.7 0.0 1.2e-43 149.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase C13 family ArgoMid PF16487.3 001309321.1_21024001_2 - 0.021 15.0 0.1 0.063 13.4 0.1 1.8 1 0 0 1 1 1 0 Mid domain of argonaute Peptidase_C14 PF00656.20 001309321.1_21024001_2 - 0.062 13.1 0.0 0.085 12.7 0.0 1.3 1 0 0 1 1 1 0 Caspase domain SH2 PF00017.22 001256934.1_21026001_1 - 7.5e-12 45.0 0.0 2e-11 43.7 0.0 1.7 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.14 001256934.1_21026001_1 - 5e-11 42.6 2.6 6.2e-11 42.3 1.2 1.9 2 0 0 2 2 2 1 SOCS box Pannexin_like PF12534.6 001205622.1_06527001_1 - 8.5e-141 468.9 0.9 1.1e-140 468.6 0.9 1.1 1 0 0 1 1 1 1 Pannexin-like TM region of LRRC8 LRR_8 PF13855.4 001205622.1_06527001_1 - 8e-30 102.3 49.5 1.6e-08 34.0 1.9 7.4 4 1 5 10 10 10 7 Leucine rich repeat LRR_4 PF12799.5 001205622.1_06527001_1 - 4.8e-16 58.4 28.5 5e-05 23.4 1.0 8.6 7 1 1 9 9 9 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001205622.1_06527001_1 - 1.6e-05 24.4 4.8 0.074 12.4 0.1 3.7 2 1 1 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.31 001205622.1_06527001_1 - 0.66 10.5 23.5 16 6.3 0.2 8.7 10 0 0 10 10 10 0 Leucine Rich Repeat PNMA PF14893.4 001256953.1_21023001_1 - 2.7e-42 145.2 0.3 4e-42 144.7 0.3 1.2 1 0 0 1 1 1 1 PNMA zf-C2H2_10 PF16588.3 001256953.1_21023001_1 - 0.0022 17.5 2.4 0.0044 16.6 2.4 1.5 1 0 0 1 1 1 1 C2H2 zinc-finger zf-CCHC PF00098.21 001256953.1_21023001_1 - 0.066 13.2 2.4 0.11 12.4 2.4 1.4 1 0 0 1 1 1 0 Zinc knuckle TPD PF14811.4 001346586.1_21029001_2 - 0.05 13.3 0.1 0.086 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function TPD sequence-motif DUF4462 PF14692.4 001037141.3_06522001_1 - 1.7 8.2 7.2 2.1 7.9 0.8 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4462) SH2 PF00017.22 001037141.3_06522001_3 - 7.8e-25 86.6 0.0 1.4e-24 85.8 0.0 1.4 1 0 0 1 1 1 1 SH2 domain Pkinase_Tyr PF07714.15 001037141.3_06522001_3 - 2.7e-19 69.3 0.5 3.9e-19 68.8 0.5 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001037141.3_06522001_3 - 1e-10 41.3 0.2 1.4e-10 40.8 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain SH3_1 PF00018.26 001037141.3_06522001_3 - 0.00058 19.3 0.0 0.0013 18.2 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 001037141.3_06522001_3 - 0.0043 16.6 0.0 0.0083 15.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 001037141.3_06522001_3 - 0.015 15.0 0.0 0.04 13.6 0.0 1.7 1 0 0 1 1 1 0 Variant SH3 domain MHC_I PF00129.16 001281907.1_06523001_1 - 1.5e-21 76.6 0.1 2.3e-21 76.0 0.1 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001281907.1_06523001_1 - 6.5e-12 45.6 0.0 1.4e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001281907.1_06523001_1 - 0.0022 18.4 0.0 0.008 16.6 0.0 1.9 1 1 1 2 2 2 1 Immunoglobulin domain Shisa PF13908.4 001281907.1_06523001_1 - 0.02 15.0 0.1 0.032 14.3 0.1 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Linker_histone PF00538.17 001256951.1_21022001_1 - 2.9e-19 69.1 0.9 2.9e-19 69.1 0.9 2.3 2 1 0 2 2 2 1 linker histone H1 and H5 family Met_10 PF02475.14 001257161.1_21023001_1 - 6e-27 94.6 0.0 8.9e-27 94.0 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.12 001257161.1_21023001_1 - 0.002 17.6 0.0 0.0031 17.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.13 001257161.1_21023001_1 - 0.09 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 DNA_methylase PF00145.15 001257161.1_21023001_1 - 0.18 11.0 0.0 0.29 10.3 0.0 1.2 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase zf-RING_UBOX PF13445.4 001257087.1_21025001_1 - 1.4e-09 37.6 7.0 1.4e-09 37.6 7.0 3.0 3 1 0 3 3 3 1 RING-type zinc-finger zf-B_box PF00643.22 001257087.1_21025001_1 - 9e-09 35.2 30.3 1.7e-07 31.1 4.9 4.0 3 1 0 3 3 2 2 B-box zinc finger zf-C3HC4 PF00097.23 001257087.1_21025001_1 - 1.2e-07 31.4 9.3 1.2e-07 31.4 9.3 3.6 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001257087.1_21025001_1 - 1.6e-07 30.9 10.3 1.6e-07 30.9 10.3 3.2 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001257087.1_21025001_1 - 4.8e-07 29.4 7.1 4.8e-07 29.4 7.1 3.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001257087.1_21025001_1 - 4.7e-06 26.5 8.7 4.7e-06 26.5 8.7 3.0 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.4 001257087.1_21025001_1 - 1.4e-05 25.1 8.6 1.4e-05 25.1 8.6 3.5 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.4 001257087.1_21025001_1 - 2.4e-05 24.0 7.8 2.4e-05 24.0 7.8 3.3 2 1 1 3 3 3 1 zinc-RING finger domain zf-RING_4 PF14570.4 001257087.1_21025001_1 - 0.0044 16.6 6.5 0.0044 16.6 6.5 3.2 4 1 0 4 4 4 1 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.4 001257087.1_21025001_1 - 0.0081 15.9 8.1 0.0081 15.9 8.1 3.6 3 0 0 3 3 2 1 Prokaryotic RING finger family 4 Phytase-like PF13449.4 001257087.1_21025001_1 - 0.055 13.3 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 Esterase-like activity of phytase Spc7 PF08317.9 001257087.1_21025001_1 - 2.2 6.9 4.2 3.3 6.4 4.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Copper-fist PF00649.16 001257087.1_21025001_1 - 3.5 7.1 7.3 0.71 9.3 3.2 2.1 2 0 0 2 2 1 0 Copper fist DNA binding domain zf-RING_11 PF17123.3 001257087.1_21025001_1 - 4.6 6.9 7.4 0.31 10.7 1.5 2.3 2 1 0 2 2 2 0 RING-like zinc finger APG6 PF04111.10 001257087.1_21025001_1 - 9.2 5.4 6.5 19 4.4 6.5 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 Cyclin_N PF00134.21 001309417.1_21025001_3 - 8.4e-19 67.5 0.1 1.4e-18 66.8 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Ank_2 PF12796.5 001242471.1_21026001_1 - 3.1e-34 117.3 3.7 4.1e-15 56.0 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001242471.1_21026001_1 - 4.9e-22 77.5 0.6 8e-10 38.7 0.0 4.5 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.28 001242471.1_21026001_1 - 4.3e-21 74.2 0.5 1.6e-08 34.5 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.4 001242471.1_21026001_1 - 9.6e-20 70.6 0.2 7.2e-08 32.7 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 001242471.1_21026001_1 - 1.5e-18 64.8 0.0 5.5e-06 26.2 0.0 5.1 4 0 0 4 4 4 3 Ankyrin repeat GrpE PF01025.17 001242471.1_21026001_1 - 4.5 6.8 10.2 9.8 5.7 10.2 1.5 1 0 0 1 1 1 0 GrpE NHL PF01436.19 001257154.1_21023001_1 - 1.1e-15 56.6 8.3 0.18 11.7 0.4 6.5 6 0 0 6 6 6 6 NHL repeat zf-RING_5 PF14634.4 001257154.1_21023001_1 - 6.9e-08 32.2 7.4 6.9e-08 32.2 7.4 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 001257154.1_21023001_1 - 7.6e-07 29.2 8.1 7.6e-07 29.2 8.1 2.6 3 0 0 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.4 001257154.1_21023001_1 - 4.7e-06 26.4 1.4 4.7e-06 26.4 1.4 2.8 2 1 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.4 001257154.1_21023001_1 - 1.4e-05 24.7 7.1 1.4e-05 24.7 7.1 2.2 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.4 001257154.1_21023001_1 - 3.4e-05 23.5 12.7 0.00011 21.9 12.7 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001257154.1_21023001_1 - 0.00025 21.0 3.6 0.00025 21.0 3.6 2.4 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING Baculo_IE-1 PF05290.9 001257154.1_21023001_1 - 0.00066 19.5 1.6 0.0012 18.7 1.6 1.3 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-C3HC4 PF00097.23 001257154.1_21023001_1 - 0.0016 18.1 6.0 0.0016 18.1 6.0 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 001257154.1_21023001_1 - 0.87 9.2 12.3 0.049 13.2 2.6 3.3 3 0 0 3 3 3 0 RING-like zinc finger BTB PF00651.29 001256942.1_21024001_1 - 1.2e-24 86.5 0.0 2.1e-24 85.8 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 001256942.1_21024001_1 - 5.3e-11 42.3 14.9 6.3e-07 29.4 2.3 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.24 001256942.1_21024001_1 - 2.9e-05 24.2 24.1 0.00035 20.7 6.0 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.6 001256942.1_21024001_1 - 0.0058 16.8 1.9 0.0058 16.8 1.9 3.3 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.4 001256942.1_21024001_1 - 0.014 16.1 4.4 0.014 16.1 4.4 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger zf-Di19 PF05605.10 001256942.1_21024001_1 - 0.02 15.1 6.7 0.02 15.1 6.7 2.1 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.4 001256942.1_21024001_1 - 0.02 14.7 2.0 0.02 14.7 2.0 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger Rtf2 PF04641.10 001256942.1_21024001_1 - 0.026 13.8 0.2 0.05 12.8 0.2 1.4 1 0 0 1 1 1 0 Rtf2 RING-finger DUF2256 PF10013.7 001256942.1_21024001_1 - 0.036 14.1 2.0 3 7.9 0.2 2.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) Elf1 PF05129.11 001256942.1_21024001_1 - 0.061 13.2 0.8 0.11 12.4 0.8 1.3 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like DUF2225 PF09986.7 001256942.1_21024001_1 - 1.6 8.3 3.1 6.3 6.3 3.4 1.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) Ribosomal_60s PF00428.17 001256942.1_21024001_1 - 2.1 8.8 4.7 9 6.8 1.6 3.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein zf-C2H2_2 PF12756.5 001256942.1_21024001_1 - 7.2 6.9 10.6 0.52 10.6 2.5 2.3 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C4 PF00105.16 001308939.1_21025001_3 - 7e-28 96.7 17.2 1.4e-27 95.8 17.2 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001308939.1_21025001_3 - 9.5e-17 61.1 0.2 4.6e-16 58.9 0.2 2.0 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Serpin PF00079.18 001146302.1_06523001_3 - 5.5e-122 407.5 0.3 6.3e-122 407.3 0.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) IL8 PF00048.18 001278930.2_21023001_3 - 6.8e-09 35.6 1.1 2.2e-08 34.0 1.1 1.8 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Dus PF01207.15 001309286.1_21024001_1 - 3.5e-73 246.3 0.2 4.4e-73 245.9 0.2 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.19 001309286.1_21024001_1 - 0.017 14.4 0.1 0.059 12.7 0.1 1.5 1 1 0 1 1 1 0 Histidine biosynthesis protein ThiG PF05690.12 001309286.1_21024001_1 - 0.026 13.7 0.0 0.042 13.0 0.0 1.3 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG NanE PF04131.12 001309286.1_21024001_1 - 0.12 11.4 0.0 0.19 10.7 0.0 1.2 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase Defensin_propep PF00879.16 001166087.1_21021001_1 - 2.2e-19 69.4 3.0 3e-19 69.0 3.0 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_beta PF00711.17 001166087.1_21021001_1 - 3.9 7.5 12.2 6 6.9 12.2 1.3 1 0 0 1 1 1 0 Beta defensin 7tm_1 PF00001.19 001163969.1_21023001_1 - 3.5e-56 190.3 11.4 4.7e-56 189.8 11.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001163969.1_21023001_1 - 5.6e-09 35.6 14.2 0.00016 21.0 7.0 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001163969.1_21023001_1 - 0.00097 18.8 6.1 0.0076 15.9 4.3 2.1 2 0 0 2 2 2 1 Olfactory receptor Ig_2 PF13895.4 001206277.1_06526001_3 - 7.4e-31 106.2 0.1 5.2e-11 42.6 0.0 4.7 3 1 1 4 4 4 4 Immunoglobulin domain Ig_3 PF13927.4 001206277.1_06526001_3 - 6.4e-30 103.5 0.5 2.1e-09 37.7 0.0 5.6 5 0 0 5 5 5 4 Immunoglobulin domain I-set PF07679.14 001206277.1_06526001_3 - 8.6e-24 83.3 0.0 4.6e-09 36.1 0.0 5.3 5 0 0 5 5 5 2 Immunoglobulin I-set domain ig PF00047.23 001206277.1_06526001_3 - 7e-21 74.1 0.4 1.3e-07 31.6 0.0 5.0 5 0 0 5 5 5 3 Immunoglobulin domain V-set PF07686.15 001206277.1_06526001_3 - 7.1e-19 67.9 1.4 4.9e-09 36.2 0.0 6.5 4 3 2 6 6 6 4 Immunoglobulin V-set domain C2-set_2 PF08205.10 001206277.1_06526001_3 - 2.3e-13 49.9 5.4 0.0023 17.8 0.1 5.2 4 1 0 4 4 4 3 CD80-like C2-set immunoglobulin domain PRA1 PF03208.17 001308942.1_21025001_3 - 1.3e-37 128.5 6.9 2.3e-37 127.7 6.9 1.4 1 0 0 1 1 1 1 PRA1 family protein Halogen_Hydrol PF10112.7 001308942.1_21025001_3 - 0.15 12.0 2.3 0.16 11.9 0.1 1.9 1 1 1 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein LRR_8 PF13855.4 001256907.1_21026001_2 - 8e-47 156.7 36.4 4.2e-13 48.7 4.9 6.6 2 2 4 6 6 6 6 Leucine rich repeat LRR_5 PF13306.4 001256907.1_21026001_2 - 9.4e-15 54.6 0.1 3.7e-06 26.8 0.1 2.4 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 001256907.1_21026001_2 - 6.5e-14 51.6 50.3 0.0036 17.5 5.6 8.6 5 2 4 10 10 10 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001256907.1_21026001_2 - 3.3e-05 23.3 19.2 0.0095 15.3 1.1 4.3 2 2 2 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.31 001256907.1_21026001_2 - 0.00076 19.5 31.5 5.3 7.8 1.0 10.5 10 1 0 10 10 10 1 Leucine Rich Repeat LBP_BPI_CETP_C PF02886.15 001035027.2_06524001_3 - 5e-75 251.9 0.1 6.9e-75 251.4 0.1 1.2 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.23 001035027.2_06524001_3 - 1.1e-34 119.3 0.1 2.6e-34 118.1 0.0 1.6 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain rRNA_processing PF08524.9 001308949.1_21022001_3 - 4.5e-10 39.6 37.1 2.6e-08 33.9 37.1 2.2 1 1 0 1 1 1 1 rRNA processing LRR_8 PF13855.4 001205447.1_06526001_1 - 2.2e-59 196.9 101.0 8.3e-11 41.4 1.1 12.7 4 3 9 13 13 13 13 Leucine rich repeat LRR_4 PF12799.5 001205447.1_06526001_1 - 3.5e-44 147.8 105.4 1.7e-06 28.1 0.8 13.6 7 3 9 16 16 16 15 Leucine Rich repeats (2 copies) Death PF00531.20 001205447.1_06526001_1 - 6.5e-05 22.9 3.8 0.00019 21.4 0.2 3.5 3 0 0 3 3 3 1 Death domain DUF3475 PF11961.6 001205447.1_06526001_1 - 0.0041 17.0 0.3 0.46 10.4 0.0 3.6 3 0 0 3 3 3 1 Domain of unknown function (DUF3475) LRR_1 PF00560.31 001205447.1_06526001_1 - 0.005 17.0 99.1 0.46 11.0 0.0 20.2 20 3 1 21 21 21 7 Leucine Rich Repeat HAD_2 PF13419.4 001205447.1_06526001_1 - 0.013 15.5 2.0 0.045 13.7 0.5 2.8 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase TLD PF07534.14 001309240.1_21024001_3 - 5e-06 26.7 0.3 2e-05 24.7 0.2 2.1 2 1 0 2 2 2 1 TLD AAA_PrkA PF08298.9 001309240.1_21024001_3 - 0.0032 16.3 0.0 0.0062 15.4 0.0 1.4 1 0 0 1 1 1 1 PrkA AAA domain MMR_HSR1 PF01926.21 001309240.1_21024001_3 - 0.013 15.5 0.0 0.024 14.6 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.4 001309240.1_21024001_3 - 0.015 14.9 0.0 0.032 13.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain TsaE PF02367.15 001309240.1_21024001_3 - 0.017 15.0 0.0 0.04 13.8 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF258 PF03193.14 001309240.1_21024001_3 - 0.067 12.9 0.0 0.17 11.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AIG1 PF04548.14 001309240.1_21024001_3 - 0.093 11.9 0.8 0.13 11.4 0.1 1.5 2 0 0 2 2 2 0 AIG1 family ATP_bind_1 PF03029.15 001309240.1_21024001_3 - 0.17 11.5 0.4 0.35 10.5 0.1 1.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein zf-H2C2_2 PF13465.4 001256949.1_21023001_1 - 2.7e-74 242.4 58.6 2.7e-09 36.9 1.1 10.2 11 0 0 11 11 10 9 Zinc-finger double domain zf-C2H2 PF00096.24 001256949.1_21023001_1 - 3.1e-61 200.4 62.8 2.6e-07 30.6 0.3 10.2 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001256949.1_21023001_1 - 8.5e-33 110.1 59.1 0.00062 20.2 0.9 9.6 10 0 0 10 10 9 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001256949.1_21023001_1 - 1e-29 101.7 44.6 0.00011 21.9 0.8 9.4 9 0 0 9 9 9 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001256949.1_21023001_1 - 7e-16 57.9 38.9 0.00084 19.3 2.1 6.7 4 2 4 8 8 8 8 Zinc ribbon domain zf-C2H2_jaz PF12171.6 001256949.1_21023001_1 - 1.1e-13 50.9 29.6 0.096 12.9 0.4 9.2 9 0 0 9 9 9 4 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 001256949.1_21023001_1 - 4.3e-12 45.4 40.6 0.4 10.4 0.3 9.2 9 0 0 9 9 9 7 zinc-finger C2H2-type XPA_N PF01286.16 001256949.1_21023001_1 - 4.7e-10 39.2 42.0 1.4 8.9 0.1 9.3 9 0 0 9 9 9 5 XPA protein N-terminal zf-BED PF02892.13 001256949.1_21023001_1 - 2.5e-08 33.7 48.7 0.14 12.1 0.8 9.3 1 1 8 9 9 9 4 BED zinc finger zf-LYAR PF08790.9 001256949.1_21023001_1 - 6.3e-07 29.1 33.4 0.88 9.4 0.2 9.3 9 0 0 9 9 9 3 LYAR-type C2HC zinc finger zf-met PF12874.5 001256949.1_21023001_1 - 7.9e-07 29.1 56.5 0.051 13.9 1.3 9.5 9 0 0 9 9 9 6 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.3 001256949.1_21023001_1 - 3.8e-06 27.4 39.5 0.061 14.0 1.3 5.6 2 1 3 6 6 5 5 zinc-ribbon family YhfH PF14149.4 001256949.1_21023001_1 - 5.7e-05 22.9 33.3 17 5.4 0.5 9.2 9 0 0 9 9 9 0 YhfH-like protein zf-trcl PF13451.4 001256949.1_21023001_1 - 8e-05 22.3 33.7 3.7 7.4 0.2 9.2 9 0 0 9 9 9 2 Probable zinc-ribbon domain C1_4 PF07975.10 001256949.1_21023001_1 - 0.00061 19.9 35.9 2.3 8.4 3.3 6.7 2 1 4 7 7 7 4 TFIIH C1-like domain HypA PF01155.17 001256949.1_21023001_1 - 0.00064 19.6 31.2 0.49 10.3 0.8 5.7 1 1 5 6 6 6 3 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FYVE PF01363.19 001256949.1_21023001_1 - 0.0021 18.1 40.0 8.8 6.4 11.2 5.9 1 1 2 3 3 3 0 FYVE zinc finger CpXC PF14353.4 001256949.1_21023001_1 - 0.0036 17.2 28.4 3.7 7.5 0.3 8.6 3 2 3 7 7 7 1 CpXC protein DUF3268 PF11672.6 001256949.1_21023001_1 - 0.0041 17.3 26.3 0.58 10.4 0.2 5.4 2 1 4 7 7 7 3 zinc-finger-containing domain Zn_ribbon_recom PF13408.4 001256949.1_21023001_1 - 0.0056 17.0 33.7 4.9 7.6 1.6 8.1 3 2 4 7 7 7 1 Recombinase zinc beta ribbon domain zf-AN1 PF01428.14 001256949.1_21023001_1 - 0.0083 16.1 49.4 7.4 6.7 1.0 10.0 9 1 1 10 10 10 0 AN1-like Zinc finger MRP-S23 PF10484.7 001256949.1_21023001_1 - 0.0099 16.0 0.0 15 5.7 0.0 5.1 6 2 0 6 6 6 0 Mitochondrial ribosomal protein S23 TFIIS_C PF01096.16 001256949.1_21023001_1 - 0.022 14.5 39.6 15 5.4 0.2 9.3 9 0 0 9 9 9 0 Transcription factor S-II (TFIIS) DNA_RNApol_7kD PF03604.11 001256949.1_21023001_1 - 0.077 12.5 35.5 12 5.5 0.1 9.2 9 0 0 9 9 9 0 DNA directed RNA polymerase, 7 kDa subunit ADK_lid PF05191.12 001256949.1_21023001_1 - 0.1 12.5 24.4 1.6 8.7 1.4 6.5 3 2 2 5 5 5 0 Adenylate kinase, active site lid LIM PF00412.20 001256949.1_21023001_1 - 0.33 11.1 33.5 6.7 6.9 2.0 7.1 2 2 5 7 7 7 0 LIM domain DUF2652 PF10851.6 001256949.1_21023001_1 - 2 8.4 7.6 0.46 10.5 1.1 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF2652) Asp_protease_2 PF13650.4 001172558.1_21029001_2 - 0.00069 20.1 0.0 0.0012 19.3 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.9 001172558.1_21029001_2 - 0.038 13.8 0.0 0.07 13.0 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.4 001172558.1_21029001_2 - 0.061 13.7 0.0 0.11 12.9 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Retrotrans_gag PF03732.15 001172558.1_21029001_3 - 3.9e-15 55.8 2.0 1.1e-14 54.3 0.1 2.3 2 0 0 2 2 2 1 Retrotransposon gag protein DUF4939 PF16297.3 001172558.1_21029001_3 - 5.2e-15 55.2 0.0 1.2e-14 54.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) KASH_CCD PF14662.4 001172558.1_21029001_3 - 0.0019 17.9 1.8 0.0032 17.2 1.8 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH zf-CCHC_5 PF14787.4 001172558.1_21029001_3 - 0.0024 17.4 0.2 0.0058 16.2 0.2 1.6 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger Rootletin PF15035.4 001172558.1_21029001_3 - 0.0058 16.6 3.3 0.011 15.7 3.3 1.4 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion bZIP_1 PF00170.19 001172558.1_21029001_3 - 0.044 13.8 1.5 0.16 12.0 1.5 2.0 1 0 0 1 1 1 0 bZIP transcription factor SHE3 PF17078.3 001172558.1_21029001_3 - 0.11 12.0 2.7 0.22 11.1 2.7 1.3 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 ZapB PF06005.10 001172558.1_21029001_3 - 0.13 12.6 5.9 0.29 11.5 5.9 1.5 1 0 0 1 1 1 0 Cell division protein ZapB DUF3450 PF11932.6 001172558.1_21029001_3 - 0.21 10.7 0.7 0.33 10.1 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) TMF_DNA_bd PF12329.6 001172558.1_21029001_3 - 0.39 10.6 3.9 0.7 9.8 3.9 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF972 PF06156.11 001172558.1_21029001_3 - 0.39 11.2 2.4 0.88 10.1 2.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Spc7 PF08317.9 001172558.1_21029001_3 - 0.72 8.5 3.2 1.2 7.8 3.2 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein CENP-H PF05837.10 001172558.1_21029001_3 - 1.1 9.6 3.9 2.9 8.2 3.9 1.6 1 0 0 1 1 1 0 Centromere protein H (CENP-H) zf-CCHC PF00098.21 001172558.1_21029001_3 - 1.3 9.1 7.2 0.34 10.9 2.2 2.5 2 0 0 2 2 2 0 Zinc knuckle IncA PF04156.12 001172558.1_21029001_3 - 1.4 8.5 3.9 2.5 7.7 3.9 1.3 1 0 0 1 1 1 0 IncA protein DivIC PF04977.13 001172558.1_21029001_3 - 1.9 8.2 3.8 4.6 7.0 3.8 1.6 1 0 0 1 1 1 0 Septum formation initiator V1R PF03402.12 001166874.1_21022001_1 - 1.1e-29 103.7 11.5 1.6e-29 103.2 11.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001166874.1_21022001_1 - 2.2e-08 33.5 12.8 3.1e-08 33.1 12.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Lig_chan PF00060.24 001185089.2_21029001_1 - 1.7e-59 199.8 0.1 2.9e-59 199.1 0.1 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel ANF_receptor PF01094.26 001185089.2_21029001_1 - 4.9e-59 200.1 0.1 8e-59 199.4 0.1 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan-Glu_bd PF10613.7 001185089.2_21029001_1 - 2.8e-45 153.1 0.1 5.2e-45 152.2 0.1 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 001185089.2_21029001_1 - 8.6e-24 84.1 0.0 1.5e-23 83.3 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 V1R PF03402.12 001166858.1_21022001_1 - 4.4e-33 114.9 12.2 5.8e-33 114.5 12.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166858.1_21022001_1 - 2.6e-10 39.8 17.5 2.9e-10 39.6 17.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF1761 PF08570.8 001166858.1_21022001_1 - 1.1 9.4 5.5 0.48 10.6 0.8 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1761) SOBP PF15279.4 001301238.1_21029001_1 - 1.8 8.9 7.1 2.5 8.4 7.1 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein zf-RING_2 PF13639.4 001301238.1_21029001_3 - 8.4e-13 48.2 7.8 8.4e-13 48.2 7.8 2.4 2 0 0 2 2 1 1 Ring finger domain zf-rbx1 PF12678.5 001301238.1_21029001_3 - 7.2e-10 38.9 4.4 2e-09 37.4 4.4 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.3 001301238.1_21029001_3 - 1.8e-08 33.8 3.4 4.9e-08 32.4 3.4 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.4 001301238.1_21029001_3 - 1.3e-07 31.2 6.2 3.5e-07 29.8 6.2 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001301238.1_21029001_3 - 4.5e-06 26.3 7.6 1.5e-05 24.6 7.6 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001301238.1_21029001_3 - 0.00013 21.7 6.3 0.00037 20.3 6.3 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.5 001301238.1_21029001_3 - 0.00021 21.1 1.5 0.00051 19.9 1.5 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.4 001301238.1_21029001_3 - 0.0052 16.5 4.7 0.0052 16.5 4.7 2.1 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 001301238.1_21029001_3 - 0.0055 16.4 4.5 0.014 15.1 4.5 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 SPT6_acidic PF14632.4 001301238.1_21029001_3 - 0.2 12.2 1.3 0.64 10.5 1.3 1.8 1 0 0 1 1 1 0 Acidic N-terminal SPT6 zf-RING-like PF08746.9 001301238.1_21029001_3 - 8.4 6.7 10.4 1.8 8.8 6.2 2.2 2 0 0 2 2 2 0 RING-like domain Lectin_C PF00059.19 001281815.1_21023001_3 - 2e-10 41.2 1.7 2e-10 41.2 1.7 1.8 2 0 0 2 2 2 1 Lectin C-type domain UL45 PF05473.10 001281815.1_21023001_3 - 6.5e-06 25.8 0.6 1.1e-05 25.0 0.6 1.4 1 1 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like TMEM132D_C PF15706.3 001281815.1_21023001_3 - 0.0016 18.1 0.3 0.0036 16.9 0.3 1.5 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Ly49 PF08391.8 001281815.1_21023001_3 - 8.2 6.7 17.8 8.2 6.7 11.8 3.4 2 1 0 2 2 2 0 Ly49-like protein, N-terminal region Filament PF00038.19 001346158.1_21024001_3 - 6.2e-94 315.0 32.7 7.3e-94 314.7 32.7 1.0 1 0 0 1 1 1 1 Intermediate filament protein Baculo_PEP_C PF04513.10 001346158.1_21024001_3 - 0.067 13.1 17.4 2.5 8.0 1.5 3.6 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus T2SSM_b PF10741.7 001346158.1_21024001_3 - 0.072 12.8 0.9 0.34 10.6 0.1 2.2 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M subtype b FUSC PF04632.10 001346158.1_21024001_3 - 1.1 7.6 4.7 2.4 6.5 4.7 1.5 1 0 0 1 1 1 0 Fusaric acid resistance protein family ECH_2 PF16113.3 001346158.1_21024001_3 - 3.4 6.9 6.3 5.6 6.2 6.3 1.4 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase V1R PF03402.12 001166867.1_21022001_1 - 5.6e-36 124.4 12.3 7.5e-36 124.0 12.3 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166867.1_21022001_1 - 1.4e-09 37.3 16.1 1.7e-09 37.1 16.1 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166867.1_21022001_1 - 6e-07 28.8 13.7 7.7e-07 28.5 13.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) FGGY_N PF00370.19 001256933.1_21024001_3 - 1.1e-85 287.0 0.0 1.6e-85 286.4 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.14 001256933.1_21024001_3 - 5.3e-64 215.5 0.2 9.9e-64 214.6 0.2 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain LRR_9 PF14580.4 001308962.1_21029001_1 - 5e-19 68.3 3.8 5.3e-18 65.0 3.1 3.2 1 1 1 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.5 001308962.1_21029001_1 - 4.3e-10 39.5 18.5 1.9e-05 24.8 1.0 4.7 2 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001308962.1_21029001_1 - 7.1e-10 38.4 17.1 1.7e-05 24.3 1.7 4.0 3 0 0 3 3 3 2 Leucine rich repeat APG6 PF04111.10 001308962.1_21029001_1 - 0.00083 18.7 23.0 0.00083 18.7 23.0 15.1 4 3 12 16 16 16 4 Autophagy protein Apg6 LRR_6 PF13516.4 001308962.1_21029001_1 - 0.0011 18.7 6.9 4.9 7.3 0.2 4.9 4 0 0 4 4 4 1 Leucine Rich repeat LRR_1 PF00560.31 001308962.1_21029001_1 - 0.0089 16.2 7.3 33 5.4 0.1 5.6 4 0 0 4 4 4 0 Leucine Rich Repeat zf-H2C2_2 PF13465.4 001256952.1_21023001_3 - 4.9e-59 194.1 78.7 3.7e-08 33.3 1.1 13.0 13 0 0 13 13 12 10 Zinc-finger double domain zf-C2H2 PF00096.24 001256952.1_21023001_3 - 9.3e-44 145.4 73.9 9.7e-06 25.6 0.2 10.6 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001256952.1_21023001_3 - 1.2e-24 84.7 69.8 0.0014 19.1 0.2 10.7 10 0 0 10 10 10 9 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001256952.1_21023001_3 - 4.6e-08 32.7 54.0 0.00088 19.0 1.0 9.6 9 0 0 9 9 9 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001256952.1_21023001_3 - 1.1e-05 25.4 51.4 0.046 13.9 0.2 9.7 10 0 0 10 10 10 5 Zinc-finger double-stranded RNA-binding C1_4 PF07975.10 001256952.1_21023001_3 - 0.0002 21.4 56.2 0.37 11.0 4.1 7.8 3 1 6 9 9 9 5 TFIIH C1-like domain Mut7-C PF01927.14 001256952.1_21023001_3 - 0.0042 17.1 6.8 0.0042 17.1 6.8 4.7 1 1 2 3 3 2 1 Mut7-C RNAse domain zf-met PF12874.5 001256952.1_21023001_3 - 0.023 15.0 0.5 0.023 15.0 0.5 11.1 11 0 0 11 11 11 0 Zinc-finger of C2H2 type BolA PF01722.16 001256952.1_21023001_3 - 0.091 12.9 11.7 3 8.0 0.4 5.0 3 2 1 4 4 4 0 BolA-like protein zinc_ribbon_15 PF17032.3 001256952.1_21023001_3 - 1.1 9.9 36.8 1.2 9.8 1.3 5.1 3 1 2 5 5 5 0 zinc-ribbon family Ta0938 PF11494.6 001256952.1_21023001_3 - 3 8.0 11.8 0.32 11.2 1.2 3.8 2 2 2 4 4 4 0 Ta0938 DUF3268 PF11672.6 001256952.1_21023001_3 - 7.3 6.8 30.4 0.12 12.5 0.7 5.6 3 1 2 6 6 6 0 zinc-finger-containing domain RanGAP1_C PF07834.9 001242478.1_21025001_1 - 6.6e-74 247.3 3.8 1.9e-73 245.8 3.8 1.8 1 1 0 1 1 1 1 RanGAP1 C-terminal domain LRR_6 PF13516.4 001242478.1_21025001_1 - 1.2e-15 56.1 5.3 0.23 11.5 0.0 9.1 9 0 0 9 9 9 3 Leucine Rich repeat LRR_4 PF12799.5 001242478.1_21025001_1 - 3.2e-06 27.2 0.9 2.4 8.6 0.0 5.0 4 1 1 5 5 4 1 Leucine Rich repeats (2 copies) SDA1 PF05285.10 001242478.1_21025001_1 - 8.7e-05 22.0 13.9 0.00015 21.2 13.9 1.3 1 0 0 1 1 1 1 SDA1 LRR_8 PF13855.4 001242478.1_21025001_1 - 0.00014 21.4 0.1 2.1 8.1 0.0 4.7 4 1 0 4 4 4 1 Leucine rich repeat CDC45 PF02724.12 001242478.1_21025001_1 - 0.0014 16.9 9.7 0.002 16.4 9.7 1.1 1 0 0 1 1 1 1 CDC45-like protein CPSF100_C PF13299.4 001242478.1_21025001_1 - 0.0015 18.6 7.3 0.0028 17.7 7.3 1.4 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal LRR_1 PF00560.31 001242478.1_21025001_1 - 0.0021 18.1 0.4 40 5.1 0.0 5.3 5 0 0 5 5 4 0 Leucine Rich Repeat Nop14 PF04147.10 001242478.1_21025001_1 - 0.0032 15.6 19.7 0.0048 15.1 19.7 1.2 1 0 0 1 1 1 1 Nop14-like family YL1 PF05764.11 001242478.1_21025001_1 - 0.0087 16.1 15.6 0.013 15.5 15.6 1.2 1 0 0 1 1 1 1 YL1 nuclear protein IFN-gamma PF00714.15 001242478.1_21025001_1 - 0.021 14.5 0.2 0.039 13.7 0.2 1.4 1 0 0 1 1 1 0 Interferon gamma Mpp10 PF04006.10 001242478.1_21025001_1 - 0.059 11.7 21.3 0.088 11.1 21.3 1.1 1 0 0 1 1 1 0 Mpp10 protein SpoIIP PF07454.9 001242478.1_21025001_1 - 0.062 12.6 6.0 0.11 11.8 6.0 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) RNA_pol_Rpc4 PF05132.12 001242478.1_21025001_1 - 0.079 13.3 6.6 0.15 12.3 6.6 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 DNA_pol_phi PF04931.11 001242478.1_21025001_1 - 0.081 10.9 30.5 0.14 10.2 30.5 1.3 1 0 0 1 1 1 0 DNA polymerase phi CobT PF06213.10 001242478.1_21025001_1 - 0.09 12.0 26.1 0.17 11.1 26.1 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Rrn6 PF10214.7 001242478.1_21025001_1 - 0.15 10.3 1.3 0.23 9.7 1.3 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Presenilin PF01080.15 001242478.1_21025001_1 - 0.17 10.5 3.8 0.24 9.9 3.8 1.1 1 0 0 1 1 1 0 Presenilin DUF2151 PF10221.7 001242478.1_21025001_1 - 0.19 10.1 3.1 0.26 9.6 3.1 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator ALMT PF11744.6 001242478.1_21025001_1 - 0.2 10.3 0.8 0.31 9.7 0.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DDHD PF02862.15 001242478.1_21025001_1 - 0.25 11.3 1.2 0.38 10.7 1.2 1.3 1 0 0 1 1 1 0 DDHD domain DUF4820 PF16091.3 001242478.1_21025001_1 - 0.44 9.7 2.8 0.76 9.0 2.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Paf1 PF03985.11 001242478.1_21025001_1 - 0.53 9.1 24.9 0.85 8.4 24.9 1.2 1 0 0 1 1 1 0 Paf1 Merozoite_SPAM PF07133.9 001242478.1_21025001_1 - 0.54 10.1 39.4 1 9.2 39.4 1.4 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) PI3K_1B_p101 PF10486.7 001242478.1_21025001_1 - 0.71 7.4 4.5 1 6.9 4.5 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RR_TM4-6 PF06459.10 001242478.1_21025001_1 - 0.81 9.3 14.7 1.6 8.4 14.7 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 THOC2_N PF16134.3 001242478.1_21025001_1 - 0.83 8.1 16.7 0.28 9.6 0.3 2.2 2 0 0 2 2 2 0 THO complex subunit 2 N-terminus SAPS PF04499.13 001242478.1_21025001_1 - 1.4 7.4 5.9 2 7.0 5.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Tim54 PF11711.6 001242478.1_21025001_1 - 1.9 7.0 11.3 2.8 6.5 11.3 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Roughex PF06020.9 001242478.1_21025001_1 - 2 7.3 17.5 3.3 6.6 17.5 1.2 1 0 0 1 1 1 0 Drosophila roughex protein NPR3 PF03666.11 001242478.1_21025001_1 - 2 7.0 5.4 3 6.4 5.4 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Na_trans_assoc PF06512.11 001242478.1_21025001_1 - 2.5 8.3 13.8 4.4 7.5 13.8 1.3 1 0 0 1 1 1 0 Sodium ion transport-associated DUF913 PF06025.10 001242478.1_21025001_1 - 2.7 6.7 8.0 5.1 5.8 8.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Sigma70_ner PF04546.11 001242478.1_21025001_1 - 2.9 7.6 25.5 7.2 6.3 25.5 1.6 1 0 0 1 1 1 0 Sigma-70, non-essential region PPP4R2 PF09184.9 001242478.1_21025001_1 - 4.2 6.7 20.7 7.6 5.9 20.7 1.3 1 0 0 1 1 1 0 PPP4R2 XAP5 PF04921.12 001242478.1_21025001_1 - 4.3 7.0 9.2 8.1 6.1 9.2 1.4 1 0 0 1 1 1 0 XAP5, circadian clock regulator TFIIF_alpha PF05793.10 001242478.1_21025001_1 - 4.7 5.5 30.0 6.9 5.0 30.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF1510 PF07423.9 001242478.1_21025001_1 - 5.1 6.3 25.7 8.1 5.7 25.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) PTPRCAP PF15713.3 001242478.1_21025001_1 - 7.6 6.7 26.5 14 5.8 26.5 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Vfa1 PF08432.8 001242478.1_21025001_1 - 9.6 6.4 12.2 16 5.6 12.2 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 AP3D1 PF06375.9 001242478.1_21025001_2 - 0.19 11.9 12.7 0.28 11.3 12.7 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Defensin_propep PF00879.16 001166092.1_21021001_1 - 4.2e-23 81.3 1.9 5.7e-23 80.9 1.9 1.2 1 0 0 1 1 1 1 Defensin propeptide PepSY_2 PF13670.4 001166092.1_21021001_1 - 0.19 11.6 0.4 0.35 10.8 0.3 1.4 1 1 0 1 1 1 0 Peptidase propeptide and YPEB domain Defensin_1 PF00323.17 001166092.1_21021001_2 - 0.0024 18.2 0.3 0.0044 17.4 0.3 1.4 1 0 0 1 1 1 1 Mammalian defensin DUF1232 PF06803.10 001206274.1_06523001_2 - 2e-09 36.9 9.8 2e-09 36.9 9.8 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1232) zf-C3HC4 PF00097.23 001206274.1_06523001_2 - 5.2e-09 35.7 4.6 9.9e-09 34.8 4.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001206274.1_06523001_2 - 2.6e-08 33.5 3.1 4.4e-08 32.7 3.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001206274.1_06523001_2 - 9.2e-08 31.8 6.6 1.3e-07 31.3 3.9 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 001206274.1_06523001_2 - 3.1e-07 30.3 7.3 7.4e-07 29.1 7.3 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.4 001206274.1_06523001_2 - 2.9e-06 26.9 5.3 6.1e-06 25.8 5.3 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001206274.1_06523001_2 - 4.4e-06 26.7 7.4 9.6e-06 25.6 7.4 1.6 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.4 001206274.1_06523001_2 - 1.5e-05 24.6 3.7 4e-05 23.2 3.7 1.6 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 001206274.1_06523001_2 - 0.00027 20.7 5.1 0.00085 19.1 5.1 1.9 1 1 0 1 1 1 1 zinc-RING finger domain zf-Nse PF11789.6 001206274.1_06523001_2 - 0.0089 15.7 0.7 0.016 14.9 0.7 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-ANAPC11 PF12861.5 001206274.1_06523001_2 - 0.1 12.5 1.8 0.18 11.7 1.8 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.5 001206274.1_06523001_2 - 0.13 12.4 3.5 0.25 11.5 3.5 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain KRTDAP PF15200.4 001304713.1_06521001_1 - 2.8e-41 139.1 0.4 4e-41 138.6 0.4 1.2 1 0 0 1 1 1 1 Keratinocyte differentiation-associated AIRS_C PF02769.20 001170339.1_21025001_3 - 5e-29 101.3 0.4 8.2e-28 97.4 0.1 2.2 2 0 0 2 2 2 1 AIR synthase related protein, C-terminal domain AIRS PF00586.22 001170339.1_21025001_3 - 7.4e-10 39.2 0.1 1.8e-09 38.0 0.1 1.7 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain ODC_AZ PF02100.15 001172714.1_21022001_3 - 5.3e-15 55.3 0.0 7.8e-15 54.7 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Ras PF00071.20 001309415.1_21025001_1 - 3.4e-61 205.4 0.1 5e-61 204.9 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001309415.1_21025001_1 - 3.8e-32 110.9 0.0 6.1e-32 110.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001309415.1_21025001_1 - 2e-11 43.5 0.0 2.9e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001309415.1_21025001_1 - 0.00039 20.4 0.0 0.00064 19.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001309415.1_21025001_1 - 0.0016 17.7 0.0 0.0022 17.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001309415.1_21025001_1 - 0.026 13.9 0.0 0.077 12.4 0.0 1.7 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001309415.1_21025001_1 - 0.065 13.0 0.0 1.8 8.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Serpin PF00079.18 001242444.1_21023001_1 - 2e-96 323.4 1.4 2.3e-96 323.2 1.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Neuralized PF07177.10 001192661.2_06529001_1 - 1.3e-249 817.1 0.0 7.8e-43 145.9 0.0 6.2 6 0 0 6 6 6 6 Neuralized FliMN_C PF01052.18 001192661.2_06529001_1 - 0.014 15.2 0.3 76 3.3 0.0 4.1 4 0 0 4 4 4 0 Type III flagellar switch regulator (C-ring) FliN C-term Tetraspannin PF00335.18 001308961.1_21024001_2 - 1.1e-45 155.9 12.5 1.4e-45 155.5 12.5 1.1 1 0 0 1 1 1 1 Tetraspanin family NfeD PF01957.16 001308961.1_21024001_2 - 0.47 10.7 3.5 0.27 11.5 0.7 1.9 2 0 0 2 2 2 0 NfeD-like C-terminal, partner-binding SUR7 PF06687.10 001308961.1_21024001_2 - 0.86 9.1 11.1 0.23 10.9 2.6 2.8 3 0 0 3 3 3 0 SUR7/PalI family IncA PF04156.12 001308961.1_21024001_2 - 8.7 6.0 8.1 0.19 11.4 1.0 1.8 2 0 0 2 2 2 0 IncA protein SOCS PF12610.6 001256911.1_21023001_1 - 2e-21 76.0 3.0 5.2e-21 74.7 3.0 1.7 1 0 0 1 1 1 1 Suppressor of cytokine signalling SOCS_box PF07525.14 001256911.1_21023001_1 - 3.7e-10 39.8 0.0 7.8e-10 38.8 0.0 1.6 1 0 0 1 1 1 1 SOCS box SH2 PF00017.22 001256911.1_21023001_1 - 6.6e-08 32.4 0.0 1.3e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 SH2 domain Defensin_propep PF00879.16 001166095.1_21021001_1 - 1.5e-08 34.7 3.8 2.4e-08 34.1 3.8 1.3 1 0 0 1 1 1 1 Defensin propeptide Defensin_propep PF00879.16 001166095.1_21021001_2 - 0.00026 21.1 0.3 0.00039 20.6 0.3 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166095.1_21021001_2 - 0.003 17.9 10.9 0.0044 17.4 10.9 1.3 1 0 0 1 1 1 1 Mammalian defensin Pro_isomerase PF00160.19 001309220.1_21022001_2 - 1.1e-51 175.1 0.1 1.3e-51 174.9 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Defensin_propep PF00879.16 001166234.1_21021001_1 - 2.5e-23 82.0 6.2 3.3e-23 81.6 6.2 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166234.1_21021001_1 - 1.2e-07 32.0 9.2 2.4e-07 31.1 9.2 1.5 1 0 0 1 1 1 1 Mammalian defensin Transket_pyr PF02779.22 001205838.2_06529001_3 - 1.1e-61 207.4 0.0 1.8e-61 206.8 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.3 001205838.2_06529001_3 - 1.1e-45 154.9 0.0 1.7e-45 154.3 0.0 1.3 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal E1_dh PF00676.18 001205838.2_06529001_3 - 1e-41 142.7 0.0 2.4e-41 141.5 0.0 1.6 1 1 1 2 2 2 1 Dehydrogenase E1 component zf-TRAF PF02176.16 001301218.1_21029001_3 - 6.1e-22 78.0 25.6 1.2e-14 54.6 9.6 4.7 3 1 1 4 4 3 2 TRAF-type zinc finger zf-C3HC4 PF00097.23 001301218.1_21029001_3 - 0.0024 17.5 13.6 0.0024 17.5 13.6 3.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) MPS2 PF17060.3 001301218.1_21029001_3 - 0.011 14.9 6.9 0.018 14.2 6.9 1.2 1 0 0 1 1 1 0 Monopolar spindle protein 2 Spc29 PF17082.3 001301218.1_21029001_3 - 0.044 13.5 4.3 0.08 12.6 4.3 1.4 1 0 0 1 1 1 0 Spindle Pole Component 29 Spc7 PF08317.9 001301218.1_21029001_3 - 0.056 12.2 13.7 0.082 11.6 13.7 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein FliJ PF02050.14 001301218.1_21029001_3 - 0.23 11.6 7.8 0.42 10.7 7.8 1.5 1 0 0 1 1 1 0 Flagellar FliJ protein KxDL PF10241.7 001301218.1_21029001_3 - 0.23 11.6 3.4 0.43 10.7 3.4 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein Tropomyosin_1 PF12718.5 001301218.1_21029001_3 - 0.28 11.2 13.3 0.65 10.0 13.3 1.6 1 1 0 1 1 1 0 Tropomyosin like T3SSipB PF16535.3 001301218.1_21029001_3 - 0.5 10.7 3.8 0.85 10.0 3.8 1.2 1 0 0 1 1 1 0 Type III cell invasion protein SipB IncA PF04156.12 001301218.1_21029001_3 - 0.78 9.4 13.3 1.5 8.5 13.3 1.4 1 0 0 1 1 1 0 IncA protein ATG16 PF08614.9 001301218.1_21029001_3 - 1.4 8.9 16.1 0.24 11.4 8.1 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.10 001301218.1_21029001_3 - 2.1 8.2 5.2 1.9 8.4 3.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.7 001301218.1_21029001_3 - 3.3 8.0 7.4 1.7 8.9 3.6 2.0 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3450 PF11932.6 001301218.1_21029001_3 - 3.9 6.6 8.1 5.9 6.0 8.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) SPATA24 PF15175.4 001301218.1_21029001_3 - 4.2 7.1 12.4 2.2 8.0 9.3 1.8 1 1 1 2 2 2 0 Spermatogenesis-associated protein 24 ADIP PF11559.6 001301218.1_21029001_3 - 4.2 7.3 12.9 2.4 8.1 9.2 1.6 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Aa_trans PF01490.16 001205943.2_06524001_1 - 3.8e-80 269.5 36.9 1.5e-43 148.9 14.8 2.3 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein SAM_1 PF00536.28 001206853.1_06529001_1 - 2.9e-08 33.9 0.1 5.1e-08 33.1 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PHAT PF09246.8 001206853.1_06529001_1 - 0.0038 16.9 0.0 0.46 10.2 0.0 2.6 3 0 0 3 3 3 2 PHAT SAM_2 PF07647.15 001206853.1_06529001_1 - 0.055 13.5 0.1 0.12 12.4 0.1 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Iso_dh PF00180.18 001195527.1_21023001_1 - 2.7e-78 263.4 0.0 3.2e-78 263.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Enolase_C PF00113.20 001267603.2_21024001_3 - 1.1e-156 520.4 0.0 1.5e-156 520.0 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.14 001267603.2_21024001_3 - 1.2e-60 203.2 0.1 2e-60 202.5 0.1 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.4 001267603.2_21024001_3 - 4e-08 33.1 0.0 6e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.9 001267603.2_21024001_3 - 0.0042 16.1 0.1 0.0088 15.1 0.1 1.5 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus Nuf2 PF03800.12 001309320.1_21024001_1 - 6.4e-37 126.7 0.2 6.4e-37 126.7 0.2 2.4 2 1 1 3 3 3 1 Nuf2 family Spc7 PF08317.9 001309320.1_21024001_1 - 0.045 12.5 49.9 0.48 9.1 20.4 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein ATG16 PF08614.9 001309320.1_21024001_1 - 2.8 8.0 36.1 0.12 12.4 19.8 2.7 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) ApoO PF09769.7 001309320.1_21024001_1 - 5.2 6.9 8.4 9.1 6.1 0.5 3.3 1 1 3 4 4 4 0 Apolipoprotein O DUF2209 PF09974.7 001309320.1_21024001_1 - 9 6.5 8.4 3.8 7.7 0.9 3.2 2 1 1 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2209) Reo_sigmaC PF04582.10 001309320.1_21024001_1 - 9.7 5.3 8.2 8.6 5.5 4.1 2.5 1 1 2 3 3 3 0 Reovirus sigma C capsid protein Pkinase PF00069.23 001309194.1_21029001_1 - 1.4e-68 231.0 0.0 1.9e-68 230.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001309194.1_21029001_1 - 2.1e-34 118.8 0.0 3.3e-34 118.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001309194.1_21029001_1 - 2.2e-05 23.8 0.0 3.5e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like DUF3480 PF11979.6 001309258.1_21029001_3 - 2.3e-170 566.2 0.0 5.1e-170 565.1 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3480) FYVE PF01363.19 001309258.1_21029001_3 - 4.7e-18 64.9 16.5 1.3e-17 63.5 16.5 1.8 1 0 0 1 1 1 1 FYVE zinc finger V1R PF03402.12 001166875.1_21022001_1 - 4.4e-33 114.9 8.2 5.5e-33 114.6 8.2 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166875.1_21022001_1 - 1.4e-11 44.0 9.5 1.8e-11 43.6 9.5 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Ras PF00071.20 001309334.1_21029001_1 - 4.4e-64 214.8 0.2 6e-64 214.4 0.2 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001309334.1_21029001_1 - 3.5e-32 111.0 0.0 5.3e-32 110.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001309334.1_21029001_1 - 2.4e-15 56.3 0.1 3.5e-15 55.8 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001309334.1_21029001_1 - 0.00025 20.4 0.1 0.00036 19.8 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001309334.1_21029001_1 - 0.0072 16.3 0.0 0.011 15.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001309334.1_21029001_1 - 0.011 15.2 0.0 0.018 14.5 0.0 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain SRPRB PF09439.8 001309334.1_21029001_1 - 0.013 14.8 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF258 PF03193.14 001309334.1_21029001_1 - 0.018 14.8 0.2 5.1 6.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Filament PF00038.19 001346217.1_21025001_2 - 3.9e-115 384.6 31.8 4.6e-115 384.4 31.8 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001346217.1_21025001_2 - 6.2e-26 91.4 40.6 6.2e-26 91.4 40.6 3.4 3 1 0 3 3 2 1 Keratin type II head CENP-F_leu_zip PF10473.7 001346217.1_21025001_2 - 9.1e-07 28.9 23.8 0.00054 19.9 5.9 3.3 1 1 2 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.10 001346217.1_21025001_2 - 2.9e-06 27.2 25.6 0.001 19.0 0.2 3.9 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein AAA_13 PF13166.4 001346217.1_21025001_2 - 5.6e-05 21.9 11.1 5.6e-05 21.9 11.1 1.5 1 1 0 1 1 1 1 AAA domain IncA PF04156.12 001346217.1_21025001_2 - 0.00029 20.6 25.8 0.0039 16.9 6.1 3.2 2 1 1 3 3 3 2 IncA protein Taxilin PF09728.7 001346217.1_21025001_2 - 0.0016 17.6 21.3 0.036 13.2 21.4 2.5 1 1 0 1 1 1 1 Myosin-like coiled-coil protein Spc7 PF08317.9 001346217.1_21025001_2 - 0.0018 17.1 29.3 0.045 12.5 12.0 2.9 1 1 1 2 2 2 2 Spc7 kinetochore protein ADIP PF11559.6 001346217.1_21025001_2 - 0.012 15.5 4.2 0.012 15.5 4.2 3.4 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Alanine_zipper PF11839.6 001346217.1_21025001_2 - 0.015 15.4 2.3 0.05 13.8 2.3 1.9 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein Jnk-SapK_ap_N PF09744.7 001346217.1_21025001_2 - 0.016 15.3 2.0 0.016 15.3 2.0 3.2 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 Tropomyosin_1 PF12718.5 001346217.1_21025001_2 - 0.31 11.0 26.2 0.022 14.8 8.4 3.5 2 1 0 2 2 2 0 Tropomyosin like Baculo_PEP_C PF04513.10 001346217.1_21025001_2 - 0.35 10.8 17.2 2.4 8.1 0.9 3.8 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus CHDCT2 PF08074.9 001346217.1_21025001_2 - 0.41 10.7 13.1 2.3 8.2 1.1 2.8 1 1 0 2 2 2 0 CHDCT2 (NUC038) domain Lebercilin PF15619.4 001346217.1_21025001_2 - 0.59 9.6 25.8 0.35 10.4 9.3 2.6 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Golgin_A5 PF09787.7 001346217.1_21025001_2 - 0.65 9.3 25.2 0.18 11.1 7.8 2.8 1 1 1 3 3 3 0 Golgin subfamily A member 5 Tup_N PF08581.8 001346217.1_21025001_2 - 0.71 10.1 19.5 0.65 10.2 0.2 5.2 2 2 3 5 5 5 0 Tup N-terminal Ax_dynein_light PF10211.7 001346217.1_21025001_2 - 0.73 9.6 25.7 0.69 9.7 4.3 3.2 1 1 2 3 3 3 0 Axonemal dynein light chain Reo_sigmaC PF04582.10 001346217.1_21025001_2 - 1.1 8.5 15.3 0.25 10.6 0.5 2.8 2 1 2 4 4 3 0 Reovirus sigma C capsid protein BRE1 PF08647.9 001346217.1_21025001_2 - 1.1 9.2 25.5 0.24 11.4 3.6 4.4 3 2 2 5 5 5 0 BRE1 E3 ubiquitin ligase RPW8 PF05659.9 001346217.1_21025001_2 - 1.2 8.7 10.7 2.8 7.5 0.2 3.3 2 2 1 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF885 PF05960.9 001346217.1_21025001_2 - 1.4 8.4 11.1 1.6 8.1 8.9 1.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF885) CALCOCO1 PF07888.9 001346217.1_21025001_2 - 1.7 7.0 30.2 1.9 6.8 12.1 2.1 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like DASH_Duo1 PF08651.8 001346217.1_21025001_2 - 1.8 8.2 6.1 10 5.9 0.2 3.7 4 0 0 4 4 3 0 DASH complex subunit Duo1 NPV_P10 PF05531.10 001346217.1_21025001_2 - 2 8.8 9.3 24 5.4 0.1 3.9 2 2 1 4 4 4 0 Nucleopolyhedrovirus P10 protein T3SS_needle_E PF08988.8 001346217.1_21025001_2 - 2.4 8.3 7.2 12 6.0 0.3 2.8 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle APG6 PF04111.10 001346217.1_21025001_2 - 2.5 7.3 27.2 0.43 9.8 6.5 2.9 1 1 0 2 2 2 0 Autophagy protein Apg6 Virulence_fact PF13769.4 001346217.1_21025001_2 - 2.5 8.1 5.1 3.3 7.8 0.4 3.0 2 1 1 3 3 3 0 Virulence factor Cob_adeno_trans PF01923.16 001346217.1_21025001_2 - 2.8 7.9 6.7 5.2 7.0 4.7 2.4 1 1 1 2 2 2 0 Cobalamin adenosyltransferase DUF1664 PF07889.10 001346217.1_21025001_2 - 3.4 7.6 15.9 6.5 6.6 3.0 4.1 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) ABC_tran_CTD PF16326.3 001346217.1_21025001_2 - 6 7.1 18.2 6.6 6.9 0.4 4.1 3 1 0 3 3 3 0 ABC transporter C-terminal domain DUF4407 PF14362.4 001346217.1_21025001_2 - 6.2 5.9 20.2 3.6e+03 -3.1 20.2 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Transposase_22 PF02994.12 001346217.1_21025001_2 - 6.2 5.4 17.5 0.049 12.3 4.9 2.3 1 1 2 3 3 3 0 L1 transposable element SPATA1_C PF15743.3 001346217.1_21025001_2 - 6.4 6.7 23.3 1.1 9.2 5.5 3.3 1 1 2 3 3 3 0 Spermatogenesis-associated C-terminus JIP_LZII PF16471.3 001346217.1_21025001_2 - 6.4 6.9 20.3 2.7 8.1 0.3 5.0 4 1 2 6 6 6 0 JNK-interacting protein leucine zipper II Rootletin PF15035.4 001346217.1_21025001_2 - 6.4 6.7 23.7 3.6 7.5 6.4 2.6 2 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Fib_alpha PF08702.8 001346217.1_21025001_2 - 6.5 6.8 22.5 1.2 9.1 3.8 3.8 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family DUF5082 PF16888.3 001346217.1_21025001_2 - 6.7 6.9 20.6 3.8 7.8 0.5 4.2 1 1 3 4 4 4 0 Domain of unknown function (DUF5082) Wtap PF17098.3 001346217.1_21025001_2 - 6.9 6.5 15.1 0.21 11.4 0.5 3.5 3 1 0 3 3 3 0 WTAP/Mum2p family Vps51 PF08700.9 001346217.1_21025001_2 - 8 6.5 10.0 2.8 8.0 0.3 3.9 3 1 1 4 4 4 0 Vps51/Vps67 V_ATPase_I PF01496.17 001346217.1_21025001_2 - 8 4.1 20.6 0.078 10.7 3.7 2.5 1 1 2 3 3 3 0 V-type ATPase 116kDa subunit family TBPIP PF07106.11 001346217.1_21025001_2 - 8 6.1 24.1 0.55 9.8 5.8 4.1 2 2 2 4 4 4 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) BTD PF09270.8 001301219.1_21026001_1 - 4.3e-75 251.0 0.0 6.4e-75 250.4 0.0 1.3 1 0 0 1 1 1 1 Beta-trefoil DNA-binding domain LAG1-DNAbind PF09271.9 001301219.1_21026001_1 - 4.7e-51 173.3 0.9 1e-50 172.2 0.9 1.6 1 0 0 1 1 1 1 LAG1, DNA binding TIG PF01833.22 001301219.1_21026001_1 - 0.0013 18.6 1.2 0.0032 17.4 0.0 2.1 2 0 0 2 2 2 1 IPT/TIG domain RHD_dimer PF16179.3 001301219.1_21026001_1 - 0.12 12.4 0.0 0.34 10.9 0.0 1.8 1 1 0 1 1 1 0 Rel homology dimerisation domain DHR-2 PF06920.11 001309171.1_21029001_2 - 7.4e-212 704.5 3.5 1.1e-211 704.0 3.5 1.2 1 0 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.4 001309171.1_21029001_2 - 8.6e-50 169.1 0.2 2.1e-49 167.8 0.2 1.7 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.6 001309171.1_21029001_2 - 3.4e-23 81.7 0.1 3.3e-22 78.5 0.1 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3398) DOCK_N PF16172.3 001309171.1_21029001_2 - 0.015 14.0 0.1 0.036 12.8 0.1 1.5 1 0 0 1 1 1 0 DOCK N-terminus Rcd1 PF04078.11 001301266.1_21029001_2 - 5e-135 448.7 0.9 6.3e-135 448.3 0.9 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Yae1_N PF09811.7 001199002.1_06522001_1 - 6.4e-13 48.0 3.1 9.1e-13 47.5 3.1 1.2 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Filament PF00038.19 001346198.1_21024001_3 - 3.4e-122 407.8 34.1 4.1e-122 407.5 34.1 1.1 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 001346198.1_21024001_3 - 0.00064 19.7 0.2 0.00064 19.7 0.2 3.9 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein FlxA PF14282.4 001346198.1_21024001_3 - 0.0088 15.9 10.6 0.0088 15.9 10.6 3.4 3 0 0 3 3 3 1 FlxA-like protein MAD PF05557.11 001346198.1_21024001_3 - 0.018 13.3 32.4 0.0097 14.2 26.5 2.6 1 1 2 3 3 3 0 Mitotic checkpoint protein RasGAP_C PF03836.13 001346198.1_21024001_3 - 0.39 10.8 24.0 0.23 11.5 0.7 3.6 2 1 2 4 4 4 0 RasGAP C-terminus DUF4407 PF14362.4 001346198.1_21024001_3 - 0.57 9.3 17.6 2.1 7.5 8.2 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) Bacillus_HBL PF05791.9 001346198.1_21024001_3 - 0.7 9.5 10.0 0.17 11.5 3.5 2.9 1 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Ribonuclease_T2 PF00445.16 001346198.1_21024001_3 - 2.2 8.3 5.3 1.5 8.8 1.4 2.3 2 1 1 3 3 3 0 Ribonuclease T2 family PHA_gran_rgn PF09650.8 001346198.1_21024001_3 - 2.7 8.2 4.9 33 4.7 0.1 3.5 2 1 2 4 4 4 0 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) Sec2p PF06428.9 001346198.1_21024001_3 - 3 7.7 20.4 2.8 7.8 3.3 4.2 2 2 1 3 3 3 0 GDP/GTP exchange factor Sec2p Keratin_2_head PF16208.3 001346198.1_21024001_3 - 3.9 7.5 57.8 0.14 12.2 51.8 1.6 2 0 0 2 2 1 0 Keratin type II head Fib_alpha PF08702.8 001346198.1_21024001_3 - 3.9 7.5 23.3 2.6 8.1 5.3 4.3 1 1 2 4 4 4 0 Fibrinogen alpha/beta chain family Atg14 PF10186.7 001346198.1_21024001_3 - 4.4 6.1 21.6 3.1 6.7 0.5 3.0 2 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4446 PF14584.4 001346198.1_21024001_3 - 7.3 6.4 20.4 4.8 7.0 0.1 4.5 3 1 2 5 5 5 0 Protein of unknown function (DUF4446) SKA1 PF07160.10 001346198.1_21024001_3 - 8 6.1 22.3 1 9.0 1.8 3.7 2 1 2 4 4 4 0 Spindle and kinetochore-associated protein 1 DUF641 PF04859.10 001346198.1_21024001_3 - 9.6 6.4 21.9 3.8 7.7 4.5 3.5 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) IL23 PF16649.3 001082522.2_21022001_2 - 4.3e-97 322.4 0.5 5.2e-97 322.2 0.5 1.1 1 0 0 1 1 1 1 Interleukin 23 subunit alpha IL6 PF00489.15 001082522.2_21022001_2 - 0.025 14.0 0.0 0.052 13.0 0.0 1.6 1 1 0 1 1 1 0 Interleukin-6/G-CSF/MGF family Beach PF02138.16 001301319.1_21027001_1 - 2.2e-113 378.1 0.0 3.2e-113 377.6 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain GRAM PF02893.18 001301319.1_21027001_1 - 6e-21 74.3 0.0 8.6e-20 70.5 0.0 2.6 2 0 0 2 2 2 1 GRAM domain WD40 PF00400.30 001301319.1_21027001_1 - 2.5e-15 56.5 27.5 0.0022 18.7 3.0 7.7 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001301319.1_21027001_1 - 2.4e-07 30.8 3.3 0.0024 18.0 0.1 4.5 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PH_BEACH PF14844.4 001301319.1_21027001_1 - 4.2e-06 26.7 0.0 0.17 11.9 0.0 3.7 2 1 0 2 2 2 2 PH domain associated with Beige/BEACH NABP PF07990.10 001301319.1_21027001_1 - 0.021 14.2 0.5 0.032 13.6 0.5 1.2 1 0 0 1 1 1 0 Nucleic acid binding protein NABP Cytochrom_D1 PF02239.14 001301319.1_21027001_1 - 0.036 12.5 0.0 0.059 11.8 0.0 1.2 1 0 0 1 1 1 0 Cytochrome D1 heme domain WD40_like PF17005.3 001301319.1_21027001_1 - 0.049 12.8 0.8 1.2 8.3 0.0 2.6 3 0 0 3 3 3 0 WD40-like domain Reprolysin_5 PF13688.4 001308552.1_21026001_1 - 5.7e-35 121.1 0.0 1.2e-34 120.1 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.4 001308552.1_21026001_1 - 1e-31 110.2 0.0 1.8e-31 109.4 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like ADAM17_MPD PF16698.3 001308552.1_21026001_1 - 1.8e-21 76.1 16.9 1.8e-21 76.1 16.9 3.6 2 1 1 3 3 3 1 Membrane-proximal domain, switch, for ADAM17 Disintegrin PF00200.21 001308552.1_21026001_1 - 3.5e-15 56.4 23.9 3.5e-15 56.4 23.9 3.2 3 1 0 3 3 3 1 Disintegrin Reprolysin_3 PF13582.4 001308552.1_21026001_1 - 1.1e-12 48.4 0.0 2.1e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.17 001308552.1_21026001_1 - 1.2e-11 44.8 0.1 1.7e-06 27.9 0.1 3.2 3 0 0 3 3 3 2 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.17 001308552.1_21026001_1 - 7.3e-08 32.6 0.0 1.6e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_4 PF13583.4 001308552.1_21026001_1 - 1.4e-05 24.7 0.1 2.4e-05 23.9 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like SH3BP5 PF05276.12 001242551.1_21023001_1 - 9.1e-95 316.7 21.4 1.2e-94 316.4 21.4 1.0 1 0 0 1 1 1 1 SH3 domain-binding protein 5 (SH3BP5) DUF148 PF02520.15 001242551.1_21023001_1 - 0.23 11.5 9.4 0.62 10.1 3.5 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF148 XhlA PF10779.7 001242551.1_21023001_1 - 0.25 11.4 4.7 0.37 10.9 0.4 2.6 2 0 0 2 2 2 0 Haemolysin XhlA WWE PF02825.18 001242551.1_21023001_1 - 0.34 11.3 2.4 1.1 9.8 0.2 2.3 2 0 0 2 2 2 0 WWE domain Sec8_exocyst PF04048.12 001242551.1_21023001_1 - 0.36 10.6 3.4 1.6 8.5 0.1 3.0 2 1 0 3 3 3 0 Sec8 exocyst complex component specific domain COG2 PF06148.9 001242551.1_21023001_1 - 0.48 10.4 7.8 1.5 8.7 1.0 2.4 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 FH2 PF02181.21 001242551.1_21023001_1 - 0.64 8.9 7.8 2.2 7.2 1.9 2.2 2 0 0 2 2 2 0 Formin Homology 2 Domain FlaC_arch PF05377.9 001242551.1_21023001_1 - 1.7 9.0 7.7 0.65 10.3 0.2 3.0 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Baculo_PEP_C PF04513.10 001242551.1_21023001_1 - 1.7 8.6 4.1 46 3.9 0.1 2.8 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus RasGAP_C PF03836.13 001242551.1_21023001_1 - 2.6 8.1 12.7 0.029 14.4 2.7 2.3 2 1 0 2 2 2 0 RasGAP C-terminus Alanine_zipper PF11839.6 001242551.1_21023001_1 - 2.8 8.1 17.9 0.8 9.9 3.3 3.5 2 1 0 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein TMPIT PF07851.11 001242551.1_21023001_1 - 2.9 6.9 10.2 0.36 9.9 0.9 2.1 2 0 0 2 2 2 0 TMPIT-like protein DUF4407 PF14362.4 001242551.1_21023001_1 - 3.6 6.7 21.1 4.9 6.3 10.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Tropomyosin_1 PF12718.5 001242551.1_21023001_1 - 8 6.5 24.5 0.024 14.7 6.6 2.7 2 1 0 2 2 2 0 Tropomyosin like Perilipin PF03036.14 001242551.1_21023001_1 - 8.4 5.2 17.3 21 3.9 17.3 1.6 1 1 0 1 1 1 0 Perilipin family F-box-like PF12937.5 001160296.1_21025001_1 - 1.1e-09 37.8 1.3 2.1e-09 36.9 1.3 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001160296.1_21025001_1 - 8.6e-07 28.6 1.2 1.9e-06 27.5 1.2 1.6 1 0 0 1 1 1 1 F-box domain MIT PF04212.16 001160296.1_21025001_1 - 0.00052 19.9 0.1 0.00096 19.1 0.1 1.4 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain DUF3682 PF12446.6 001160296.1_21025001_1 - 0.011 16.0 2.8 0.02 15.2 2.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) TPR_2 PF07719.15 001160296.1_21025001_1 - 0.036 14.1 0.9 0.32 11.1 0.5 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.26 001160296.1_21025001_1 - 0.056 13.2 0.1 0.14 11.9 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Filament PF00038.19 001346241.1_21026001_1 - 1e-112 376.7 25.6 1.2e-112 376.4 25.6 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001346241.1_21026001_1 - 5.3e-33 114.3 102.1 3.1e-19 69.6 21.6 4.2 2 2 2 4 4 2 2 Keratin type II head CENP-F_leu_zip PF10473.7 001346241.1_21026001_1 - 2.1e-05 24.4 26.2 5.2e-05 23.2 8.8 3.3 1 1 2 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Reo_sigmaC PF04582.10 001346241.1_21026001_1 - 6e-05 22.5 6.4 0.012 14.8 2.2 2.3 2 0 0 2 2 2 2 Reovirus sigma C capsid protein TPR_MLP1_2 PF07926.10 001346241.1_21026001_1 - 7.5e-05 22.7 32.0 0.00015 21.7 1.1 3.8 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein DUF4407 PF14362.4 001346241.1_21026001_1 - 0.00013 21.3 16.5 0.011 15.0 0.0 2.4 1 1 1 2 2 2 1 Domain of unknown function (DUF4407) ADIP PF11559.6 001346241.1_21026001_1 - 0.00086 19.3 5.5 0.00086 19.3 5.5 3.9 3 1 1 4 4 4 1 Afadin- and alpha -actinin-Binding Spc7 PF08317.9 001346241.1_21026001_1 - 0.0017 17.2 13.3 0.0017 17.2 13.3 3.5 1 1 3 4 4 4 1 Spc7 kinetochore protein Atg14 PF10186.7 001346241.1_21026001_1 - 0.0024 16.9 8.7 0.0024 16.9 8.7 2.2 1 1 0 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 TSNAXIP1_N PF15739.3 001346241.1_21026001_1 - 0.0061 16.8 1.8 0.0061 16.8 1.8 3.4 2 1 1 4 4 4 1 Translin-associated factor X-interacting N-terminus Alanine_zipper PF11839.6 001346241.1_21026001_1 - 0.013 15.7 4.8 0.013 15.7 4.8 2.1 3 0 0 3 3 2 0 Alanine-zipper, major outer membrane lipoprotein Baculo_PEP_C PF04513.10 001346241.1_21026001_1 - 0.027 14.4 16.5 0.17 11.8 4.2 4.0 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus AAA_13 PF13166.4 001346241.1_21026001_1 - 0.13 10.8 14.8 0.19 10.2 14.0 1.5 1 1 0 1 1 1 0 AAA domain MCC-bdg_PDZ PF10506.7 001346241.1_21026001_1 - 0.4 10.6 11.8 0.024 14.5 5.7 2.2 3 0 0 3 3 1 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DASH_Duo1 PF08651.8 001346241.1_21026001_1 - 0.68 9.6 6.5 4.8 6.9 1.3 3.4 3 0 0 3 3 3 0 DASH complex subunit Duo1 Jnk-SapK_ap_N PF09744.7 001346241.1_21026001_1 - 0.68 10.0 26.0 1.8 8.6 5.1 3.6 2 1 1 4 4 4 0 JNK_SAPK-associated protein-1 IncA PF04156.12 001346241.1_21026001_1 - 0.86 9.2 28.0 7.3 6.2 17.1 3.5 2 1 1 3 3 3 0 IncA protein Rootletin PF15035.4 001346241.1_21026001_1 - 1.4 8.8 18.4 0.36 10.7 5.6 2.3 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion SPATA1_C PF15743.3 001346241.1_21026001_1 - 3.1 7.7 16.2 0.27 11.2 0.4 3.0 2 1 0 2 2 2 0 Spermatogenesis-associated C-terminus Golgin_A5 PF09787.7 001346241.1_21026001_1 - 3.5 6.9 22.6 2.3 7.5 10.5 2.5 1 1 2 3 3 3 0 Golgin subfamily A member 5 TMPIT PF07851.11 001346241.1_21026001_1 - 6.1 5.8 14.7 10 5.1 5.0 2.4 1 1 1 2 2 2 0 TMPIT-like protein TEX13 PF15186.4 001346241.1_21026001_1 - 8.4 5.9 9.5 2 7.9 4.9 2.2 2 0 0 2 2 2 0 Testis-expressed sequence 13 protein family ABC_tran_CTD PF16326.3 001346241.1_21026001_1 - 8.6 6.6 19.8 0.13 12.4 5.8 3.7 3 0 0 3 3 3 0 ABC transporter C-terminal domain Syntaxin-6_N PF09177.9 001346241.1_21026001_1 - 9.4 6.7 11.7 1.7 9.1 3.3 3.2 1 1 2 3 3 3 0 Syntaxin 6, N-terminal PARP PF00644.18 001301262.1_21024001_1 - 1.4e-48 165.1 0.0 2.1e-48 164.6 0.0 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.18 001301262.1_21024001_1 - 6.4e-16 58.5 0.1 1.6e-15 57.3 0.1 1.7 1 0 0 1 1 1 1 WWE domain Flu_NP PF00506.16 001301262.1_21024001_2 - 0.054 12.0 0.3 0.074 11.5 0.3 1.1 1 0 0 1 1 1 0 Influenza virus nucleoprotein Ion_trans PF00520.29 001245905.1_21025001_1 - 1.7e-47 161.6 52.8 6.4e-31 107.3 23.3 2.1 2 0 0 2 2 2 2 Ion transport protein Cytochrome-c551 PF10643.7 001245905.1_21025001_1 - 2.5 7.5 6.0 0.35 10.3 0.3 2.4 2 0 0 2 2 2 0 Photosystem P840 reaction-centre cytochrome c-551 Lectin_C PF00059.19 001301255.1_21029001_2 - 2.5e-135 443.1 55.6 1.3e-19 70.7 1.4 10.7 10 0 0 10 10 10 10 Lectin C-type domain fn2 PF00040.17 001301255.1_21029001_2 - 2.9e-14 52.9 5.1 1.2e-13 51.0 5.1 2.2 1 0 0 1 1 1 1 Fibronectin type II domain UL45 PF05473.10 001301255.1_21029001_2 - 5.1e-07 29.4 24.0 0.16 11.5 0.0 8.7 9 1 1 10 10 10 5 UL45 protein, carbohydrate-binding C-type lectin-like Xlink PF00193.15 001301255.1_21029001_2 - 3.3e-05 24.1 12.4 7.3 6.9 0.0 8.3 9 0 0 9 9 9 1 Extracellular link domain Intimin_C PF07979.9 001301255.1_21029001_2 - 0.14 12.5 4.5 10 6.4 0.0 5.4 8 0 0 8 8 8 0 Intimin C-type lectin domain SBF PF01758.14 001163968.1_21023001_1 - 6.7e-41 140.0 16.3 6.7e-41 140.0 16.3 2.0 1 1 1 2 2 2 1 Sodium Bile acid symporter family DUF4231 PF14015.4 001163968.1_21023001_1 - 0.15 12.4 0.4 0.51 10.7 0.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) Mem_trans PF03547.16 001163968.1_21023001_1 - 0.41 8.8 13.3 0.023 12.9 6.2 2.2 1 1 1 3 3 3 0 Membrane transport protein Wzy_C_2 PF11846.6 001163968.1_21023001_1 - 1.9 8.2 0.0 1.9 8.2 0.0 3.2 4 1 0 5 5 5 0 Virulence factor membrane-bound polymerase, C-terminal 7tm_1 PF00001.19 001081837.2_21024001_3 - 5.1e-38 130.7 9.5 7.4e-38 130.2 9.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001081837.2_21024001_3 - 8.1e-09 35.1 9.7 1.6e-08 34.1 9.7 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001081837.2_21024001_3 - 3.5e-05 23.1 5.5 8.4e-05 21.9 4.8 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001081837.2_21024001_3 - 0.004 16.8 2.1 0.0066 16.1 2.0 1.6 1 1 0 1 1 1 1 Olfactory receptor SIR2_2 PF13289.4 001314066.1_06525001_1 - 3.4e-16 59.5 0.0 6.3e-16 58.6 0.0 1.4 1 0 0 1 1 1 1 SIR2-like domain Pkinase PF00069.23 001301247.1_21029001_1 - 2.4e-64 217.1 0.0 4.6e-64 216.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001301247.1_21029001_1 - 3e-43 147.9 0.0 6.1e-43 146.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 001301247.1_21029001_1 - 0.017 14.9 0.0 0.017 14.9 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family TEP1_N PF05386.9 001301247.1_21029001_2 - 0.068 12.6 0.7 0.2 11.1 0.7 1.8 1 0 0 1 1 1 0 TEP1 N-terminal domain TSP_C PF05735.10 001308952.1_21029001_2 - 7.6e-97 322.9 0.7 1.1e-96 322.4 0.7 1.2 1 0 0 1 1 1 1 Thrombospondin C-terminal region TSP_3 PF02412.16 001308952.1_21029001_2 - 1.3e-55 184.6 147.5 2.5e-12 46.1 12.3 9.8 7 2 2 9 9 9 8 Thrombospondin type 3 repeat TSP_1 PF00090.17 001308952.1_21029001_2 - 5.8e-46 154.4 56.3 6.1e-17 61.4 9.7 4.6 4 0 0 4 4 3 3 Thrombospondin type 1 domain VWC PF00093.16 001308952.1_21029001_2 - 2.8e-12 46.6 19.4 2.8e-12 46.6 19.4 6.0 4 3 1 5 5 1 1 von Willebrand factor type C domain cEGF PF12662.5 001308952.1_21029001_2 - 4.7e-07 29.5 16.5 1.7e-05 24.5 1.3 4.1 3 0 0 3 3 3 2 Complement Clr-like EGF-like EGF_3 PF12947.5 001308952.1_21029001_2 - 3.6e-06 26.9 11.2 3.6e-06 26.9 11.2 4.8 4 0 0 4 4 3 1 EGF domain EGF_CA PF07645.13 001308952.1_21029001_2 - 2e-05 24.6 3.1 2e-05 24.6 3.1 5.0 4 0 0 4 4 3 3 Calcium-binding EGF domain Laminin_G_3 PF13385.4 001308952.1_21029001_2 - 9.9e-05 22.4 0.7 0.00099 19.2 0.0 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.22 001308952.1_21029001_2 - 0.00059 20.3 0.1 0.0013 19.2 0.1 1.4 1 0 0 1 1 1 1 Laminin G domain EGF PF00008.25 001308952.1_21029001_2 - 0.0027 17.8 12.2 0.0027 17.8 12.2 6.0 6 0 0 6 6 4 2 EGF-like domain Laminin_G_1 PF00054.21 001308952.1_21029001_2 - 0.086 12.9 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Laminin G domain NRIP1_repr_4 PF15690.3 001256955.1_21027001_1 - 9.6e-160 530.9 4.7 3e-159 529.3 4.7 1.9 1 0 0 1 1 1 1 Nuclear receptor-interacting protein 1 repression 4 NRIP1_repr_1 PF15687.3 001256955.1_21027001_1 - 6.6e-142 472.6 23.3 6.6e-142 472.6 23.3 2.6 3 0 0 3 3 3 1 Nuclear receptor-interacting protein 1 repression 1 NRIP1_repr_2 PF15688.3 001256955.1_21027001_1 - 2.4e-120 402.1 27.8 2.4e-120 402.1 27.8 2.5 3 0 0 3 3 3 1 Nuclear receptor-interacting protein 1 repression 2 NRIP1_repr_3 PF15689.3 001256955.1_21027001_1 - 7.3e-46 154.3 0.5 1e-44 150.6 0.2 3.3 2 0 0 2 2 2 1 Nuclear receptor-interacting protein 1 repression 3 TBP PF00352.19 001309243.1_21023001_3 - 1.3e-44 149.9 0.3 2.2e-22 78.7 0.1 2.2 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.6 001309243.1_21023001_3 - 0.097 12.6 0.0 0.21 11.6 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3378) Connexin PF00029.17 001309226.1_21027001_1 - 3.2e-92 308.2 3.3 4.7e-92 307.7 3.3 1.3 1 0 0 1 1 1 1 Connexin Connexin43 PF03508.11 001309226.1_21027001_1 - 1.2e-10 40.6 15.4 2.8e-10 39.4 15.4 1.7 1 0 0 1 1 1 1 Gap junction alpha-1 protein (Cx43) Connexin40_C PF16791.3 001309226.1_21027001_1 - 0.0042 18.2 1.4 0.0092 17.1 1.4 1.5 1 0 0 1 1 1 1 Connexin 40 C-terminal domain UPF0767 PF15990.3 001309469.1_21022001_1 - 1.4e-36 124.4 0.0 1.9e-36 123.9 0.0 1.2 1 0 0 1 1 1 1 UPF0767 family Ras PF00071.20 001192338.3_06523001_1 - 3.1e-51 173.0 0.0 3.7e-51 172.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001192338.3_06523001_1 - 2.8e-24 85.5 0.0 4.2e-24 85.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001192338.3_06523001_1 - 4.6e-08 32.6 0.0 6.3e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family ABC_tran PF00005.25 001192338.3_06523001_1 - 0.024 15.0 0.0 0.043 14.2 0.0 1.3 1 0 0 1 1 1 0 ABC transporter Gtr1_RagA PF04670.10 001192338.3_06523001_1 - 0.034 13.4 0.0 0.044 13.0 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_16 PF13191.4 001192338.3_06523001_1 - 0.042 14.1 0.0 0.085 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.7 001192338.3_06523001_1 - 0.23 11.0 0.0 1.7 8.3 0.0 2.1 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation SRP19 PF01922.15 001330470.1_26227001_2 - 0.32 11.8 1.9 0.85 10.5 1.9 1.7 1 0 0 1 1 1 0 SRP19 protein HlyIII PF03006.18 001256979.1_21023001_1 - 3.5e-50 170.7 18.4 3.5e-50 170.7 18.4 1.5 2 0 0 2 2 2 1 Haemolysin-III related Pkinase PF00069.23 001309254.1_21025001_3 - 6.4e-67 225.5 0.0 8.9e-67 225.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001309254.1_21025001_3 - 8e-41 139.9 0.0 1.3e-40 139.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PB1 PF00564.22 001309254.1_21025001_3 - 5.1e-13 48.6 0.2 1.1e-12 47.5 0.2 1.6 1 0 0 1 1 1 1 PB1 domain Kinase-like PF14531.4 001309254.1_21025001_3 - 1.3e-06 27.8 0.0 0.00062 19.0 0.0 2.4 2 0 0 2 2 2 2 Kinase-like FTA2 PF13095.4 001309254.1_21025001_3 - 0.037 13.5 0.0 0.067 12.7 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.21 001309254.1_21025001_3 - 0.13 12.0 0.0 16 5.2 0.0 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.12 001309254.1_21025001_3 - 0.13 11.4 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Vps52 PF04129.10 001193060.1_06526001_1 - 1e-229 763.4 0.8 1.3e-229 763.0 0.8 1.1 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.7 001193060.1_06526001_1 - 1.9e-12 46.3 4.4 3e-09 35.7 0.9 2.2 2 0 0 2 2 2 2 Exocyst complex component Sec3 Dor1 PF04124.10 001193060.1_06526001_1 - 0.0085 14.7 1.5 0.016 13.8 1.5 1.4 1 0 0 1 1 1 1 Dor1-like family COG6 PF06419.9 001193060.1_06526001_1 - 0.017 13.3 6.0 0.71 7.9 3.1 2.5 2 0 0 2 2 2 0 Conserved oligomeric complex COG6 Spc7 PF08317.9 001193060.1_06526001_1 - 0.052 12.3 4.1 0.14 10.9 4.1 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein COG2 PF06148.9 001193060.1_06526001_1 - 0.16 12.0 2.2 0.58 10.1 2.2 1.9 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 APG17 PF04108.10 001193060.1_06526001_1 - 0.24 10.4 8.6 0.046 12.7 0.5 2.7 3 0 0 3 3 3 0 Autophagy protein Apg17 PspA_IM30 PF04012.10 001193060.1_06526001_1 - 0.57 9.6 6.0 4.9 6.5 1.2 2.3 2 0 0 2 2 2 0 PspA/IM30 family COG5 PF10392.7 001193060.1_06526001_1 - 0.58 10.2 6.8 11 6.1 0.1 2.5 2 0 0 2 2 2 0 Golgi transport complex subunit 5 DUF1664 PF07889.10 001193060.1_06526001_1 - 1.6 8.6 5.3 0.64 9.9 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Lectin_C PF00059.19 001081807.2_21026001_2 - 5e-23 81.8 3.1 6.4e-23 81.4 0.1 2.6 3 1 0 3 3 3 1 Lectin C-type domain Prominin PF05478.9 001081807.2_21026001_2 - 0.033 12.0 7.2 0.05 11.4 7.2 1.2 1 0 0 1 1 1 0 Prominin UL45 PF05473.10 001081807.2_21026001_2 - 0.035 13.6 0.1 0.084 12.4 0.1 1.5 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like DegS PF05384.9 001081807.2_21026001_2 - 0.37 10.1 14.7 0.57 9.5 14.7 1.2 1 0 0 1 1 1 0 Sensor protein DegS DDHD PF02862.15 001081807.2_21026001_2 - 0.47 10.4 3.9 0.66 9.9 3.9 1.1 1 0 0 1 1 1 0 DDHD domain Phage_GPO PF05929.9 001081807.2_21026001_2 - 1.7 8.1 10.0 2.4 7.6 10.0 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Homeobox PF00046.27 001191351.1_06522001_2 - 1.6e-21 75.8 9.6 2.8e-21 75.0 9.6 1.4 1 0 0 1 1 1 1 Homeobox domain Somatostatin PF03002.13 001191351.1_06522001_2 - 0.038 13.8 2.4 0.093 12.6 2.4 1.6 1 0 0 1 1 1 0 Somatostatin/Cortistatin family SelK_SelG PF10961.6 001168396.1_21022001_2 - 1.1e-29 102.8 0.3 1.1e-29 102.8 0.3 1.7 2 0 0 2 2 2 1 Selenoprotein SelK_SelG Arm_APC_u3 PF16629.3 001301314.1_21029001_2 - 1.8e-169 562.7 21.5 1.8e-169 562.7 21.5 3.9 4 0 0 4 4 3 1 Armadillo-associated region on APC APC_basic PF05956.9 001301314.1_21029001_2 - 2.3e-111 372.4 70.2 2.3e-111 372.4 70.2 9.4 7 2 0 10 10 2 1 APC basic domain EB1_binding PF05937.9 001301314.1_21029001_2 - 8.2e-92 306.4 26.2 8.2e-92 306.4 26.2 8.7 9 3 1 11 11 3 1 EB-1 Binding Domain APC_r PF05923.10 001301314.1_21029001_2 - 4.1e-71 233.3 46.3 1.8e-11 43.3 1.6 9.0 8 0 0 8 8 8 7 APC repeat APC_u5 PF16630.3 001301314.1_21029001_2 - 1.4e-53 179.9 6.6 1.4e-53 179.9 6.6 5.3 5 0 0 5 5 1 1 Unstructured region on APC between 1st and 2nd catenin-bdg motifs APC_u14 PF16635.3 001301314.1_21029001_2 - 4.5e-43 145.6 11.5 4.5e-43 145.6 11.5 5.6 5 0 0 5 5 2 1 Unstructured region on APC between SAMP and APC_crr APC_u15 PF16636.3 001301314.1_21029001_2 - 6e-39 132.2 7.3 6e-39 132.2 7.3 7.6 6 2 2 8 8 5 1 Unstructured region on APC between APC_crr regions 5 and 6 APC_u9 PF16633.3 001301314.1_21029001_2 - 1.7e-36 125.0 12.4 1.7e-36 125.0 12.4 6.4 7 0 0 7 7 1 1 Unstructured region on APC between 1st two creatine-rich regions APC_N_CC PF16689.3 001301314.1_21029001_2 - 1.8e-28 98.2 7.3 1.8e-28 98.2 7.3 3.2 4 0 0 4 4 3 1 Coiled-coil N-terminus of APC, dimerisation domain SAMP PF05924.9 001301314.1_21029001_2 - 2.4e-28 96.4 14.4 5.8e-10 38.0 1.7 3.9 3 0 0 3 3 3 3 SAMP Motif APC_u13 PF16634.3 001301314.1_21029001_2 - 2.9e-27 94.2 1.4 2.9e-27 94.2 1.4 2.6 2 0 0 2 2 2 1 Unstructured region on APC between APC_crr and SAMP Arm PF00514.21 001301314.1_21029001_2 - 8.9e-27 92.1 15.1 1.9e-07 30.8 0.5 6.7 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat APC_15aa PF05972.9 001301314.1_21029001_2 - 5.9e-21 73.2 28.1 5.5e-05 23.0 0.4 5.8 6 0 0 6 6 5 4 APC 15 residue motif Suppressor_APC PF11414.6 001301314.1_21029001_2 - 1.3e-20 73.1 2.2 1.3e-20 73.1 2.2 3.5 3 0 0 3 3 3 1 Adenomatous polyposis coli tumour suppressor protein JIP_LZII PF16471.3 001301314.1_21029001_2 - 0.47 10.5 10.1 0.07 13.2 3.3 3.2 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II PDZ PF00595.22 001242552.1_21023001_1 - 2.2e-21 75.9 0.1 3.3e-21 75.3 0.1 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001242552.1_21023001_1 - 1.1e-07 32.0 0.1 1.5e-07 31.5 0.1 1.2 1 0 0 1 1 1 1 PDZ domain HSP70 PF00012.18 001256923.1_21025001_2 - 3.3e-262 870.9 3.5 3.7e-262 870.7 3.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 001256923.1_21025001_2 - 1.6e-16 59.9 0.1 1e-14 54.0 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.4 001256923.1_21025001_2 - 0.00072 19.8 0.9 7.1 7.0 0.0 3.5 3 1 0 3 3 3 2 Cell division protein FtsA FGGY_C PF02782.14 001256923.1_21025001_2 - 0.011 15.4 0.0 0.025 14.2 0.0 1.6 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Radial_spoke_3 PF06098.9 001256923.1_21025001_2 - 0.69 9.0 7.6 0.098 11.8 3.6 1.5 2 0 0 2 2 2 0 Radial spoke protein 3 DUF3813 PF12758.5 001256923.1_21025001_2 - 2.4 8.4 4.6 3.9 7.8 1.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3813) NADH-G_4Fe-4S_3 PF10588.7 001097606.3_21024001_1 - 1.2 8.5 5.3 2.6 7.5 5.3 1.5 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 7tm_1 PF00001.19 001097606.3_21024001_2 - 1.7e-47 161.8 10.8 1.7e-47 161.8 10.8 1.7 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001097606.3_21024001_2 - 1.8e-08 34.0 15.0 3.2e-08 33.1 15.0 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001097606.3_21024001_2 - 0.00058 19.1 9.7 0.00058 19.1 9.7 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srab PF10292.7 001097606.3_21024001_2 - 0.0086 14.9 7.6 0.23 10.2 2.5 2.5 2 0 0 2 2 2 2 Serpentine type 7TM GPCR receptor class ab chemoreceptor 7tm_4 PF13853.4 001097606.3_21024001_2 - 5.8 6.4 17.6 34 3.9 17.6 2.6 1 1 0 1 1 1 0 Olfactory receptor JmjC PF02373.20 001206316.1_06529001_3 - 1.8e-42 144.3 0.1 4.2e-42 143.1 0.1 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.4 001206316.1_06529001_3 - 6.9e-33 113.0 8.3 6.9e-33 113.0 8.3 2.6 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.4 001206316.1_06529001_3 - 4.5e-15 55.5 5.4 4.5e-15 55.5 5.4 3.6 2 1 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.4 001206316.1_06529001_3 - 1.4e-14 53.2 4.4 1.4e-14 53.2 4.4 3.0 2 0 0 2 2 2 1 PHD-finger JmjN PF02375.15 001206316.1_06529001_3 - 3.9e-14 52.2 0.0 9e-14 51.0 0.0 1.7 1 0 0 1 1 1 1 jmjN domain PHD PF00628.27 001206316.1_06529001_3 - 8.1e-08 31.9 23.9 7.5e-07 28.8 1.1 4.3 4 0 0 4 4 4 2 PHD-finger LBR_tudor PF09465.8 001206316.1_06529001_3 - 6.9e-05 22.4 1.2 0.016 14.8 0.2 2.8 2 0 0 2 2 2 2 Lamin-B receptor of TUDOR domain 53-BP1_Tudor PF09038.8 001206316.1_06529001_3 - 0.027 14.3 0.1 0.25 11.2 0.1 2.1 1 1 1 2 2 2 0 Tumour suppressor p53-binding protein-1 Tudor DUF4537 PF15057.4 001206316.1_06529001_3 - 0.12 12.2 0.3 0.31 10.9 0.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4537) HECT PF00632.23 001192188.2_06529001_1 - 3.5e-94 315.6 0.0 5.3e-94 315.0 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.25 001192188.2_06529001_1 - 0.00043 19.7 0.5 0.0011 18.5 0.5 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif GCR PF02155.13 001195191.1_21026001_2 - 1.1e-174 580.7 6.7 1.4e-174 580.4 6.7 1.1 1 0 0 1 1 1 1 Glucocorticoid receptor Hormone_recep PF00104.28 001195191.1_21026001_2 - 5.2e-30 104.5 5.6 1.3e-29 103.2 4.2 2.0 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001195191.1_21026001_2 - 3.6e-28 97.7 13.0 6.7e-28 96.8 13.0 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Globin PF00042.20 001164016.1_21021001_1 - 8e-21 74.5 1.1 1e-20 74.2 0.7 1.4 2 0 0 2 2 2 1 Globin Ion_trans PF00520.29 001256930.1_21024001_3 - 1.5e-50 171.6 0.6 2.2e-50 171.1 0.6 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 001256930.1_21024001_3 - 9.6e-27 93.0 0.0 1.8e-26 92.2 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 001256930.1_21024001_3 - 7.8e-13 48.1 6.0 7.8e-13 48.1 6.0 2.5 3 0 0 3 3 3 1 Ion channel PKD_channel PF08016.10 001256930.1_21024001_3 - 0.0079 14.8 2.6 0.013 14.1 1.1 1.8 2 0 0 2 2 2 1 Polycystin cation channel DUF973 PF06157.9 001256930.1_21024001_3 - 0.035 13.0 0.2 0.035 13.0 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF973) Sporozoite_P67 PF05642.9 001256930.1_21024001_3 - 0.46 8.4 1.1 0.66 7.8 1.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Sigma_reg_N PF13800.4 001256930.1_21024001_3 - 2.4 8.4 3.8 17 5.6 0.0 3.2 3 0 0 3 3 3 0 Sigma factor regulator N-terminal SGS PF05002.13 001286856.1_21023001_3 - 6.3e-34 115.8 2.2 1.7e-33 114.4 2.2 1.8 1 0 0 1 1 1 1 SGS domain CS PF04969.14 001286856.1_21023001_3 - 8.7e-19 68.2 2.8 2.1e-18 67.0 2.8 1.7 1 0 0 1 1 1 1 CS domain TPR_2 PF07719.15 001286856.1_21023001_3 - 2.5e-08 33.3 7.7 0.0022 17.9 0.3 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.4 001286856.1_21023001_3 - 3.4e-07 30.1 2.7 0.011 15.9 0.3 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.4 001286856.1_21023001_3 - 1.1e-06 29.0 3.6 0.0015 18.8 1.1 2.6 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.26 001286856.1_21023001_3 - 1.3e-06 27.9 10.6 0.0053 16.4 1.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.4 001286856.1_21023001_3 - 2.2e-06 28.1 0.1 0.018 15.6 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.4 001286856.1_21023001_3 - 0.00028 20.4 5.7 0.0095 15.5 0.3 3.3 2 1 1 3 3 3 1 TPR repeat TPR_8 PF13181.4 001286856.1_21023001_3 - 0.00087 19.2 5.9 0.069 13.3 0.2 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.4 001286856.1_21023001_3 - 0.0083 16.3 3.0 1.1 9.5 0.4 2.6 1 1 1 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.5 001286856.1_21023001_3 - 0.011 15.8 2.0 0.021 14.9 2.0 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 CheC PF04509.10 001286856.1_21023001_3 - 0.02 14.7 0.0 0.24 11.2 0.0 2.5 3 0 0 3 3 3 0 CheC-like family TPR_9 PF13371.4 001286856.1_21023001_3 - 0.022 14.8 0.4 1.2 9.2 0.4 2.4 1 1 0 2 2 2 0 Tetratricopeptide repeat TPR_20 PF14561.4 001286856.1_21023001_3 - 0.027 14.7 1.0 1.1 9.5 0.1 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.4 001286856.1_21023001_3 - 0.075 13.7 0.6 0.93 10.3 0.2 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF2018 PF09442.8 001286856.1_21023001_3 - 0.09 13.6 0.1 0.26 12.1 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF2018) SHNi-TPR PF10516.7 001286856.1_21023001_3 - 0.46 9.8 2.4 7 6.1 0.1 3.1 2 1 0 2 2 2 0 SHNi-TPR TPR_6 PF13174.4 001286856.1_21023001_3 - 3.9 8.2 6.4 2.6 8.7 0.1 3.6 4 1 0 4 4 2 0 Tetratricopeptide repeat Adap_comp_sub PF00928.19 001204844.1_21029001_3 - 7.4e-61 205.7 0.3 1.1e-60 205.2 0.3 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Defensin_propep PF00879.16 001166093.1_21021001_1 - 1.1e-16 60.7 0.8 1.7e-16 60.1 0.8 1.3 1 0 0 1 1 1 1 Defensin propeptide LNS2 PF08235.11 001206156.2_06529001_3 - 6.2e-104 346.3 0.0 9e-104 345.7 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.12 001206156.2_06529001_3 - 3.3e-45 152.1 0.0 6.1e-45 151.3 0.0 1.5 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.3 001206156.2_06529001_3 - 7.1e-33 112.7 0.0 1.4e-32 111.7 0.0 1.5 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain ubiquitin PF00240.21 001256912.1_21027001_1 - 2.6e-17 62.2 1.8 4.1e-17 61.5 1.8 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.29 001256912.1_21027001_1 - 2.3e-07 30.5 1.0 5.9e-07 29.1 1.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.6 001256912.1_21027001_1 - 5.8e-06 25.9 0.9 9.6e-06 25.2 0.9 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.8 001256912.1_21027001_1 - 0.0027 18.2 0.0 0.0071 16.9 0.0 1.8 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD Rad60-SLD_2 PF13881.4 001256912.1_21027001_1 - 0.0051 16.8 0.2 0.01 15.8 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 001256912.1_21027001_1 - 0.03 14.8 0.0 0.11 12.9 0.0 1.9 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain Atg8 PF02991.14 001256912.1_21027001_1 - 0.11 12.6 0.1 0.2 11.7 0.1 1.3 1 0 0 1 1 1 0 Autophagy protein Atg8 ubiquitin like HOIP-UBA PF16678.3 001256912.1_21027001_1 - 0.16 11.8 0.1 0.36 10.7 0.1 1.5 1 0 0 1 1 1 0 UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase Collagen PF01391.16 001256912.1_21027001_1 - 2.2 8.0 18.7 0.028 14.0 11.1 1.7 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) Y_phosphatase PF00102.25 001309162.1_21029001_1 - 7.9e-158 522.9 0.2 7.1e-82 274.4 0.0 2.4 2 0 0 2 2 2 2 Protein-tyrosine phosphatase CD45 PF12567.6 001309162.1_21029001_1 - 3.7e-22 78.0 6.4 1.1e-21 76.5 6.4 1.9 1 0 0 1 1 1 1 Leukocyte receptor CD45 fn3 PF00041.19 001309162.1_21029001_1 - 1.3e-19 70.2 0.1 1e-05 25.7 0.0 3.8 3 0 0 3 3 3 3 Fibronectin type III domain PTP_N PF12453.6 001309162.1_21029001_1 - 1.2e-09 37.6 0.7 3e-09 36.3 0.7 1.7 1 0 0 1 1 1 1 Protein tyrosine phosphatase N terminal Y_phosphatase3 PF13350.4 001309162.1_21029001_1 - 1e-06 28.8 0.0 0.032 14.0 0.0 2.3 2 0 0 2 2 2 2 Tyrosine phosphatase family DSPc PF00782.18 001309162.1_21029001_1 - 0.0001 22.0 0.0 0.099 12.3 0.0 2.7 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 001309162.1_21029001_1 - 0.0001 22.3 0.0 1.3 9.0 0.0 3.5 3 0 0 3 3 3 2 Inositol hexakisphosphate Y_phosphatase2 PF03162.11 001309162.1_21029001_1 - 0.0032 16.9 0.0 0.27 10.7 0.0 2.4 2 0 0 2 2 2 1 Tyrosine phosphatase family GnsAB_toxin PF08178.9 001309162.1_21029001_1 - 0.069 13.0 0.0 0.37 10.6 0.0 2.1 2 0 0 2 2 2 0 GnsA/GnsB toxin of bacterial toxin-antitoxin system zf-H2C2_2 PF13465.4 001256922.1_21023001_1 - 1.6e-83 271.5 90.7 5.1e-10 39.2 1.1 12.1 12 0 0 12 12 12 11 Zinc-finger double domain zf-C2H2 PF00096.24 001256922.1_21023001_1 - 1.9e-67 220.0 90.3 1.2e-06 28.5 0.5 11.3 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001256922.1_21023001_1 - 7.9e-39 128.8 87.2 0.00067 20.1 0.8 11.3 11 0 0 11 11 11 11 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001256922.1_21023001_1 - 3.3e-22 77.8 76.8 0.0002 21.1 1.3 11.9 12 0 0 12 12 11 9 C2H2-type zinc finger XPA_N PF01286.16 001256922.1_21023001_1 - 8.9e-15 54.3 49.0 0.38 10.7 0.4 11.4 11 0 0 11 11 11 9 XPA protein N-terminal Zn-ribbon_8 PF09723.8 001256922.1_21023001_1 - 8.9e-12 44.8 62.8 0.028 14.4 5.0 9.0 5 3 5 11 11 10 10 Zinc ribbon domain zf-C2H2_jaz PF12171.6 001256922.1_21023001_1 - 1e-09 38.3 53.3 0.044 14.0 0.3 11.0 11 0 0 11 11 11 5 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 001256922.1_21023001_1 - 6e-09 35.4 72.3 0.0048 16.5 0.3 11.0 11 0 0 11 11 11 5 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 001256922.1_21023001_1 - 8.6e-08 32.7 47.0 0.048 14.3 1.5 6.2 2 2 4 6 6 6 6 zinc-ribbon family C1_1 PF00130.20 001256922.1_21023001_1 - 0.0001 22.0 52.2 0.15 11.8 0.2 8.7 2 1 5 9 9 9 4 Phorbol esters/diacylglycerol binding domain (C1 domain) FYVE PF01363.19 001256922.1_21023001_1 - 0.00055 19.9 60.7 0.096 12.7 11.7 6.8 1 1 5 6 6 6 4 FYVE zinc finger BHD_1 PF10403.7 001256922.1_21023001_1 - 0.0014 18.2 8.6 4.3 7.1 0.1 6.1 6 1 1 7 7 7 1 Rad4 beta-hairpin domain 1 YhfH PF14149.4 001256922.1_21023001_1 - 0.094 12.6 54.2 7.3 6.5 0.3 11.1 11 0 0 11 11 11 0 YhfH-like protein zf-trcl PF13451.4 001256922.1_21023001_1 - 0.18 11.6 48.9 7.6 6.4 0.1 10.2 10 1 0 10 10 10 0 Probable zinc-ribbon domain C1_4 PF07975.10 001256922.1_21023001_1 - 0.25 11.5 58.0 0.3 11.2 1.6 7.8 1 1 8 10 10 10 0 TFIIH C1-like domain ADK_lid PF05191.12 001256922.1_21023001_1 - 0.27 11.1 37.1 0.036 13.9 3.0 6.9 5 2 4 9 9 9 0 Adenylate kinase, active site lid zf-AN1 PF01428.14 001256922.1_21023001_1 - 2.9 8.0 79.7 0.84 9.7 2.4 11.3 7 3 4 11 11 11 0 AN1-like Zinc finger Arc_trans_TRASH PF08394.8 001256922.1_21023001_1 - 3.5 7.9 23.0 1.5 9.1 0.1 7.7 6 3 3 9 9 9 0 Archaeal TRASH domain BolA PF01722.16 001256922.1_21023001_1 - 7.7 6.7 21.0 10 6.4 0.2 5.5 3 2 2 5 5 5 0 BolA-like protein Pkinase PF00069.23 001256587.1_06529001_2 - 1.5e-56 191.6 0.0 2.6e-56 190.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001256587.1_06529001_2 - 1.2e-42 145.9 0.0 2e-42 145.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.6 001256587.1_06529001_2 - 5.6e-21 74.1 2.0 3.4e-19 68.3 0.1 2.5 2 0 0 2 2 2 2 Oxidative-stress-responsive kinase 1 C terminal Paralemmin PF03285.13 001204119.1_06523001_1 - 5.3e-115 384.2 14.0 5.3e-115 384.2 14.0 1.3 2 0 0 2 2 2 1 Paralemmin CALCOCO1 PF07888.9 001204119.1_06523001_1 - 0.0084 14.6 15.8 0.015 13.8 15.8 1.4 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like DUF4472 PF14739.4 001204119.1_06523001_1 - 0.15 12.7 18.5 1.7 9.3 8.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) Caldesmon PF02029.13 001204119.1_06523001_1 - 0.31 9.6 16.1 0.41 9.2 16.1 1.3 1 0 0 1 1 1 0 Caldesmon Prominin PF05478.9 001204119.1_06523001_1 - 0.56 8.0 3.1 0.77 7.5 3.1 1.2 1 0 0 1 1 1 0 Prominin DASH_Dam1 PF08653.8 001204119.1_06523001_1 - 0.56 9.9 1.7 23 4.7 0.1 2.7 2 0 0 2 2 2 0 DASH complex subunit Dam1 V_ATPase_I PF01496.17 001204119.1_06523001_1 - 1.7 6.3 6.5 2.2 5.9 6.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PilJ PF13675.4 001204119.1_06523001_1 - 2 8.4 6.4 0.47 10.4 1.3 2.2 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term TMPIT PF07851.11 001204119.1_06523001_1 - 2.5 7.1 7.8 0.3 10.1 3.5 1.6 1 1 1 2 2 2 0 TMPIT-like protein bZIP_2 PF07716.13 001204119.1_06523001_1 - 6.7 6.7 18.0 0.28 11.2 6.7 2.6 2 0 0 2 2 2 0 Basic region leucine zipper PspB PF06667.10 001204119.1_06523001_1 - 8 6.5 6.0 7.9 6.5 3.5 2.2 1 1 1 2 2 2 0 Phage shock protein B FlaC_arch PF05377.9 001204119.1_06523001_1 - 8.8 6.7 9.6 0.65 10.3 3.6 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Tho2 PF11262.6 001204119.1_06523001_1 - 9.1 5.2 10.6 16 4.4 10.6 1.5 1 1 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Filament PF00038.19 001346192.1_21026001_2 - 8.5e-87 291.5 32.6 1e-86 291.2 32.6 1.1 1 0 0 1 1 1 1 Intermediate filament protein CENP-F_leu_zip PF10473.7 001346192.1_21026001_2 - 0.01 15.7 27.6 0.51 10.2 11.4 3.6 3 1 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.10 001346192.1_21026001_2 - 1.1 9.1 21.1 0.73 9.7 0.7 4.2 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) POX PF07526.9 001346192.1_21026001_2 - 3.5 8.1 9.9 1 9.8 6.3 2.0 2 0 0 2 2 2 0 Associated with HOX Aminopep PF10023.7 001346192.1_21026001_2 - 5.2 6.2 10.4 0.19 10.9 4.0 1.7 2 0 0 2 2 2 0 Putative aminopeptidase GAS PF13851.4 001346192.1_21026001_2 - 5.7 6.1 33.4 1 8.6 12.3 3.8 2 2 2 4 4 4 0 Growth-arrest specific micro-tubule binding DivIC PF04977.13 001346192.1_21026001_2 - 6.4 6.5 23.5 0.89 9.2 0.2 5.2 4 1 1 5 5 5 0 Septum formation initiator NNMT_PNMT_TEMT PF01234.15 001163975.1_21022001_1 - 8.3e-95 316.7 0.0 9.4e-95 316.5 0.0 1.0 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_23 PF13489.4 001163975.1_21022001_1 - 0.0017 18.1 0.0 0.0043 16.9 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 001163975.1_21022001_1 - 0.018 15.5 0.0 0.062 13.8 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.10 001163975.1_21022001_1 - 0.029 14.9 0.0 0.059 14.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.4 001163975.1_21022001_1 - 0.12 13.0 0.0 0.67 10.6 0.0 2.1 1 1 1 2 2 2 0 Methyltransferase domain UPF0180 PF03698.11 001163975.1_21022001_1 - 0.14 12.2 0.0 0.4 10.7 0.0 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0180) TMF_DNA_bd PF12329.6 001309269.1_21029001_3 - 0.00094 19.0 12.0 0.00094 19.0 12.0 43.0 25 12 20 46 46 46 4 TATA element modulatory factor 1 DNA binding HALZ PF02183.16 001309269.1_21029001_3 - 0.002 18.2 1.5 0.002 18.2 1.5 30.6 32 2 1 33 33 33 6 Homeobox associated leucine zipper AXIN1_TNKS_BD PF16646.3 001309269.1_21029001_3 - 1.5 9.6 4.7 9.8 7.0 0.6 4.5 2 0 0 2 2 2 0 Axin-1 tankyrase binding domain Copine PF07002.14 001171745.1_21024001_2 - 2.5e-82 275.4 0.0 7.3e-82 273.9 0.0 1.7 2 0 0 2 2 2 1 Copine C2 PF00168.28 001171745.1_21024001_2 - 3.6e-24 84.9 0.0 2.3e-11 43.7 0.0 2.3 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.7 001171745.1_21024001_2 - 7.5e-06 26.1 0.0 1.2e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.26 001171745.1_21024001_2 - 0.00071 19.7 0.0 0.0016 18.6 0.0 1.5 2 0 0 2 2 2 1 von Willebrand factor type A domain RNase_P_pop3 PF08228.9 001171745.1_21024001_2 - 0.026 14.4 0.1 0.05 13.5 0.1 1.4 1 0 0 1 1 1 0 RNase P subunit Pop3 Glyco_tranf_2_3 PF13641.4 001081801.2_21026001_2 - 4.2e-19 69.2 0.1 6.3e-15 55.6 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Chitin_synth_2 PF03142.13 001081801.2_21026001_2 - 7.3e-18 64.4 4.1 8.3e-14 51.0 2.1 3.3 2 1 0 2 2 2 2 Chitin synthase Glycos_transf_2 PF00535.24 001081801.2_21026001_2 - 2.5e-09 37.1 0.0 0.00015 21.5 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.4 001081801.2_21026001_2 - 2.1e-07 30.9 11.8 8.4e-07 28.9 11.8 2.2 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.4 001081801.2_21026001_2 - 0.0055 16.1 0.0 0.012 15.0 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 21 DUF3742 PF12553.6 001081801.2_21026001_2 - 1.7 8.7 4.1 2.7 8.0 2.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3742) IL1_propep PF02394.14 001082500.2_21024001_3 - 4.9e-39 133.5 0.9 8.4e-39 132.7 0.9 1.4 1 0 0 1 1 1 1 Interleukin-1 propeptide IL1 PF00340.17 001082500.2_21024001_3 - 3.4e-37 126.7 0.0 5.9e-37 125.9 0.0 1.4 1 0 0 1 1 1 1 Interleukin-1 / 18 Gb3_synth PF04572.10 001163877.1_21023001_1 - 4.5e-44 149.7 0.4 7e-44 149.1 0.4 1.3 1 0 0 1 1 1 1 Alpha 1,4-glycosyltransferase conserved region Gly_transf_sug PF04488.13 001163877.1_21023001_1 - 3.7e-22 78.7 0.0 6.6e-22 77.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.5 001163877.1_21023001_1 - 0.01 15.0 0.0 0.015 14.5 0.0 1.1 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain V1R PF03402.12 001166871.1_21022001_1 - 4.7e-32 111.5 15.8 6.7e-32 111.0 15.8 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001166871.1_21022001_1 - 6.5e-08 32.0 12.7 8.4e-08 31.6 12.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001166871.1_21022001_1 - 1.9e-06 27.1 17.7 2.3e-06 26.8 17.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Lep_receptor_Ig PF06328.9 001301172.1_21029001_2 - 6.9e-32 109.2 0.7 2.6e-31 107.4 0.7 2.1 1 0 0 1 1 1 1 Ig-like C2-type domain fn3 PF00041.19 001301172.1_21029001_2 - 1.3e-25 89.4 13.0 9.3e-09 35.4 0.1 5.5 6 0 0 6 6 6 4 Fibronectin type III domain IL6Ra-bind PF09240.8 001301172.1_21029001_2 - 3.3e-06 27.3 0.1 8.1e-06 26.0 0.1 1.7 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding EpoR_lig-bind PF09067.8 001301172.1_21029001_2 - 3.4e-06 27.1 0.2 9.9e-06 25.6 0.2 1.8 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding Pur_ac_phosph_N PF16656.3 001301172.1_21029001_2 - 0.00054 20.3 12.6 0.029 14.8 0.1 4.1 3 1 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.3 001301172.1_21029001_2 - 0.0016 18.4 0.0 0.023 14.7 0.0 2.6 3 0 0 3 3 3 1 Fibronectin type III domain Interfer-bind PF09294.8 001301172.1_21029001_2 - 0.002 18.3 0.1 0.72 10.1 0.0 3.0 3 0 0 3 3 3 1 Interferon-alpha/beta receptor, fibronectin type III GIT1_C PF12205.6 001301316.1_21029001_3 - 1.2e-47 160.7 2.2 1.2e-47 160.7 2.2 2.3 2 0 0 2 2 2 1 G protein-coupled receptor kinase-interacting protein 1 C term GIT_CC PF16559.3 001301316.1_21029001_3 - 8.7e-29 99.2 7.7 1.8e-28 98.2 7.7 1.6 1 0 0 1 1 1 1 GIT coiled-coil Rho guanine nucleotide exchange factor GIT_SHD PF08518.9 001301316.1_21029001_3 - 2e-26 91.2 1.6 1.7e-13 49.8 0.1 2.6 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT ArfGap PF01412.16 001301316.1_21029001_3 - 9.1e-26 90.0 1.0 1.4e-25 89.4 0.0 1.9 2 0 0 2 2 1 1 Putative GTPase activating protein for Arf Ank_2 PF12796.5 001301316.1_21029001_3 - 1.3e-08 35.2 0.0 4e-08 33.6 0.0 1.9 2 0 0 2 2 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001301316.1_21029001_3 - 3.9e-07 30.1 0.0 1.3e-06 28.5 0.0 1.9 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.4 001301316.1_21029001_3 - 5.7e-06 26.6 0.0 0.00045 20.6 0.0 2.8 2 1 1 3 3 2 2 Ankyrin repeats (many copies) Ank PF00023.28 001301316.1_21029001_3 - 0.00091 19.4 0.0 0.0051 17.1 0.0 2.4 2 0 0 2 2 1 1 Ankyrin repeat GAS PF13851.4 001301316.1_21029001_3 - 0.0069 15.7 2.7 0.015 14.6 2.7 1.4 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Shugoshin_N PF07558.9 001301316.1_21029001_3 - 0.052 13.3 8.0 0.12 12.2 8.0 1.6 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region Sen15 PF09631.8 001301316.1_21029001_3 - 0.092 12.9 0.0 0.32 11.2 0.0 1.9 1 0 0 1 1 1 0 Sen15 protein TTRAP PF14203.4 001301316.1_21029001_3 - 0.16 11.8 0.1 0.58 10.0 0.1 2.0 2 0 0 2 2 2 0 Putative tranposon-transfer assisting protein DMPK_coil PF08826.8 001301316.1_21029001_3 - 0.34 10.9 2.1 0.89 9.6 2.1 1.7 1 0 0 1 1 1 0 DMPK coiled coil domain like DUF5094 PF17015.3 001301316.1_21029001_3 - 4.2 7.3 6.3 11 6.0 6.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) DUF3347 PF11827.6 001301316.1_21029001_3 - 4.6 7.2 7.7 11 6.1 7.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) DUF972 PF06156.11 001301316.1_21029001_3 - 8.7 6.9 6.4 1.6 9.3 2.3 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF972) Ras PF00071.20 001308960.1_21029001_1 - 4.5e-56 188.8 0.1 6e-56 188.4 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001308960.1_21029001_1 - 5.4e-35 120.1 0.0 7.9e-35 119.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001308960.1_21029001_1 - 3.5e-15 55.8 0.1 5e-15 55.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001308960.1_21029001_1 - 8.2e-06 25.8 0.0 1.7e-05 24.7 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001308960.1_21029001_1 - 0.0024 17.2 0.0 0.0033 16.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001308960.1_21029001_1 - 0.014 14.8 0.1 0.033 13.6 0.1 1.6 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001308960.1_21029001_1 - 0.019 14.8 0.1 0.13 12.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF258 SRPRB PF09439.8 001308960.1_21029001_1 - 0.039 13.3 0.0 0.057 12.7 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_24 PF13479.4 001308960.1_21029001_1 - 0.049 13.2 0.0 0.071 12.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 001308960.1_21029001_1 - 0.099 12.9 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.4 001308960.1_21029001_1 - 0.11 12.7 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.4 001308960.1_21029001_1 - 0.16 11.6 0.1 0.38 10.4 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain MHC_I_3 PF16497.3 001252304.2_21024001_3 - 1.3e-75 253.2 0.2 2.2e-75 252.4 0.2 1.3 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001252304.2_21024001_3 - 3.7e-10 40.0 0.0 1.2e-09 38.4 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001252304.2_21024001_3 - 1.9e-05 24.2 0.0 2.8e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 LRR_8 PF13855.4 001191450.1_06529001_1 - 1.5e-99 325.5 86.9 1e-15 57.1 0.7 10.3 4 4 6 10 10 10 10 Leucine rich repeat EGF PF00008.25 001191450.1_06529001_1 - 5.3e-41 138.4 155.3 9e-08 32.1 5.2 12.6 13 0 0 13 13 11 9 EGF-like domain LRR_5 PF13306.4 001191450.1_06529001_1 - 7.8e-36 122.7 7.5 1.9e-10 40.7 0.1 4.6 4 0 0 4 4 4 4 Leucine rich repeats (6 copies) LRR_4 PF12799.5 001191450.1_06529001_1 - 1.4e-33 114.1 65.4 8.9e-05 22.6 0.7 12.5 7 4 5 12 12 12 12 Leucine Rich repeats (2 copies) LRRNT PF01462.16 001191450.1_06529001_1 - 1e-23 82.4 69.5 4.8e-09 35.5 2.8 9.6 10 0 0 10 10 8 4 Leucine rich repeat N-terminal domain Laminin_G_2 PF02210.22 001191450.1_06529001_1 - 4.3e-23 82.1 0.0 6.8e-23 81.5 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain LRR_9 PF14580.4 001191450.1_06529001_1 - 3.3e-22 78.7 20.3 1.8e-06 27.5 0.4 5.6 4 1 1 5 5 5 5 Leucine-rich repeat hEGF PF12661.5 001191450.1_06529001_1 - 3.8e-21 74.8 132.5 7.5e-07 29.5 5.1 13.6 12 0 0 12 12 10 9 Human growth factor-like EGF Laminin_G_1 PF00054.21 001191450.1_06529001_1 - 6.6e-21 74.8 0.0 1.1e-20 74.1 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain LRRCT PF01463.22 001191450.1_06529001_1 - 9e-10 38.2 35.7 0.0039 17.5 0.2 7.3 8 0 0 8 8 5 4 Leucine rich repeat C-terminal domain EGF_CA PF07645.13 001191450.1_06529001_1 - 0.0025 17.9 5.8 0.0025 17.9 5.8 12.5 7 3 5 12 12 12 3 Calcium-binding EGF domain EGF_3 PF12947.5 001191450.1_06529001_1 - 0.0034 17.4 1.5 0.0034 17.4 1.5 12.9 13 1 1 14 14 9 5 EGF domain Laminin_G_3 PF13385.4 001191450.1_06529001_1 - 0.063 13.3 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily FXa_inhibition PF14670.4 001191450.1_06529001_1 - 3.3 7.9 126.3 0.23 11.6 5.1 11.9 5 3 5 10 10 9 0 Coagulation Factor Xa inhibitory site LRR_1 PF00560.31 001191450.1_06529001_1 - 3.8 8.2 54.7 5.2 7.8 0.0 15.2 17 4 1 18 18 16 0 Leucine Rich Repeat Lactamase_B_6 PF16661.3 001308417.1_21029001_3 - 2.3e-63 213.0 0.0 4.1e-63 212.2 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.4 001308417.1_21029001_3 - 7.3e-43 146.5 2.3 8.2e-43 146.4 0.0 2.0 2 0 0 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.6 001308417.1_21029001_3 - 8.3e-21 74.2 0.0 1.7e-20 73.2 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.10 001308417.1_21029001_3 - 2.4e-15 56.1 0.0 5.8e-15 54.8 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.25 001308417.1_21029001_3 - 3.1e-06 27.2 0.1 6.2e-06 26.2 0.1 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.5 001308417.1_21029001_3 - 0.00027 20.4 0.1 0.00049 19.5 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain MBOAT PF03062.17 001301149.1_21025001_3 - 2.6e-68 230.8 40.3 3.5e-68 230.4 40.3 1.2 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family EAP30 PF04157.14 001309172.1_21024001_3 - 4.1e-41 140.7 1.4 5.4e-41 140.3 1.4 1.2 1 0 0 1 1 1 1 EAP30/Vps36 family MA3 PF02847.15 001309172.1_21024001_3 - 0.011 15.6 1.3 0.18 11.6 0.2 2.4 2 0 0 2 2 2 0 MA3 domain TTRAP PF14203.4 001309172.1_21024001_3 - 0.11 12.3 4.4 0.29 11.0 1.3 2.3 2 0 0 2 2 2 0 Putative tranposon-transfer assisting protein ETC_C1_NDUFA5 PF04716.12 001309295.1_21023001_1 - 4.1e-27 93.6 0.3 7e-27 92.9 0.3 1.4 1 0 0 1 1 1 1 ETC complex I subunit conserved region BEX PF04538.10 001309414.1_21022001_2 - 1.1e-20 74.4 18.8 2.6e-20 73.2 18.8 1.6 1 0 0 1 1 1 1 Brain expressed X-linked like family AlphaC_N PF08829.8 001309414.1_21022001_2 - 0.11 12.0 0.9 0.16 11.5 0.9 1.2 1 0 0 1 1 1 0 Alpha C protein N terminal Trypan_PARP PF05887.9 001309414.1_21022001_2 - 0.29 11.0 20.4 0.45 10.4 20.4 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) FAM176 PF14851.4 001309414.1_21022001_2 - 1.6 8.3 8.6 2.5 7.7 8.6 1.3 1 0 0 1 1 1 0 FAM176 family Trypsin PF00089.24 001354760.1_06524001_3 - 4.6e-46 157.3 0.0 6.1e-46 156.9 0.0 1.2 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 001354760.1_06524001_3 - 1.3e-11 44.7 0.0 2.4e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 CUB domain Trypsin_2 PF13365.4 001354760.1_06524001_3 - 0.00053 20.8 0.0 0.0013 19.5 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain LRR_8 PF13855.4 001242479.1_21025001_3 - 2e-104 341.2 64.5 4.5e-14 51.8 0.8 10.3 4 2 9 13 13 13 13 Leucine rich repeat LRR_4 PF12799.5 001242479.1_21025001_3 - 4.1e-46 153.9 24.7 1e-05 25.6 0.2 12.5 8 3 5 14 14 14 12 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001242479.1_21025001_3 - 2.1e-16 59.8 0.2 0.0021 17.4 0.0 6.2 2 2 4 6 6 6 6 Leucine-rich repeat LRR_1 PF00560.31 001242479.1_21025001_3 - 1.4e-14 52.1 36.6 7.4 7.4 0.0 17.8 18 2 0 18 18 18 2 Leucine Rich Repeat LRR_5 PF13306.4 001242479.1_21025001_3 - 2.7e-07 30.5 0.0 0.027 14.3 0.0 3.4 3 1 1 4 4 4 2 Leucine rich repeats (6 copies) LRRCT PF01463.22 001242479.1_21025001_3 - 0.00097 19.4 9.0 0.14 12.7 0.2 4.2 3 0 0 3 3 3 2 Leucine rich repeat C-terminal domain LRR_6 PF13516.4 001242479.1_21025001_3 - 0.0014 18.4 36.1 0.073 13.0 0.4 12.8 18 0 0 18 18 18 2 Leucine Rich repeat LRRNT PF01462.16 001242479.1_21025001_3 - 0.02 14.4 23.3 0.021 14.3 4.2 3.6 4 0 0 4 4 4 0 Leucine rich repeat N-terminal domain IL8 PF00048.18 001114941.1_21021001_2 - 6.9e-25 86.8 1.2 8.8e-25 86.5 1.2 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Kinesin PF00225.21 001205802.2_06528001_1 - 3.2e-112 374.6 0.1 4.1e-112 374.3 0.1 1.1 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.3 001205802.2_06528001_1 - 7e-70 234.7 0.4 2.7e-69 232.8 0.1 2.2 2 0 0 2 2 2 1 Kinesin-associated Microtub_bd PF16796.3 001205802.2_06528001_1 - 3.5e-23 82.1 0.0 6.5e-23 81.2 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding FHA PF00498.24 001205802.2_06528001_1 - 4.2e-06 26.9 0.1 1.6e-05 25.0 0.0 2.0 2 0 0 2 2 2 1 FHA domain Sigma70_ner PF04546.11 001205802.2_06528001_1 - 0.026 14.3 1.2 0.63 9.8 0.1 2.9 3 0 0 3 3 3 0 Sigma-70, non-essential region FAD-oxidase_C PF02913.17 001206719.1_06528001_2 - 4.1e-57 193.5 0.0 5.4e-57 193.1 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.21 001206719.1_06528001_2 - 1.5e-38 131.6 0.0 2.6e-38 130.7 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain p450 PF00067.20 001146163.2_21024001_1 - 3.5e-126 421.5 0.1 4e-126 421.3 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_M48 PF01435.16 001301234.1_21026001_1 - 1.3e-71 240.3 0.0 1.8e-71 239.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M48 Peptidase_M48_N PF16491.3 001301234.1_21026001_1 - 7.8e-66 221.3 4.4 1.8e-65 220.1 4.4 1.6 1 0 0 1 1 1 1 CAAX prenyl protease N-terminal, five membrane helices TMEM156 PF15106.4 001283068.1_21022001_3 - 9.6e-125 414.3 9.2 9.6e-125 414.3 9.2 1.9 3 0 0 3 3 3 1 TMEM156 protein family Branch PF02485.19 001105534.2_21025001_2 - 2.2e-63 213.9 0.3 2.9e-63 213.5 0.3 1.1 1 0 0 1 1 1 1 Core-2/I-Branching enzyme Interferon PF00143.17 001114536.2_21022001_1 - 1.1e-66 223.8 0.3 1.2e-66 223.7 0.3 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain DUF429 PF04250.11 001114536.2_21022001_1 - 0.069 12.8 0.0 0.082 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF429) PDEase_I PF00233.17 001163977.1_21029001_3 - 6.9e-65 219.0 0.2 1.9e-60 204.4 0.0 2.4 2 0 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase Actin PF00022.17 001309319.1_21024001_2 - 1.2e-84 284.1 0.0 1.5e-83 280.5 0.0 1.9 1 1 0 1 1 1 1 Actin CBFD_NFYB_HMF PF00808.21 001081900.2_21023001_3 - 1.2e-28 99.0 0.6 1.8e-28 98.5 0.6 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.22 001081900.2_21023001_3 - 4.1e-05 23.9 0.0 6.8e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.14 001081900.2_21023001_3 - 0.0039 17.1 0.0 0.0066 16.3 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit CENP-T_C PF15511.4 001081900.2_21023001_3 - 0.0061 16.5 0.0 0.01 15.8 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CortBP2 PF09727.7 001163896.1_21028001_3 - 1.9e-62 210.5 27.1 1.9e-62 210.5 27.1 7.1 2 1 4 6 6 6 3 Cortactin-binding protein-2 DMPK_coil PF08826.8 001163896.1_21028001_3 - 0.012 15.6 1.5 0.012 15.6 1.5 12.3 5 2 7 13 13 13 0 DMPK coiled coil domain like DUF3596 PF12167.6 001163896.1_21028001_3 - 0.062 13.1 0.9 0.54 10.1 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3596) V1R PF03402.12 001166851.1_21022001_1 - 4.1e-40 138.0 17.6 5.8e-40 137.5 17.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166851.1_21022001_1 - 9.6e-16 57.6 20.7 1.3e-15 57.2 20.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166851.1_21022001_1 - 0.00098 18.3 20.0 0.0018 17.5 20.0 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) BTB PF00651.29 001257124.1_21025001_1 - 2.1e-25 89.0 0.0 4.4e-25 87.9 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.13 001257124.1_21025001_1 - 6.1e-18 64.7 1.5 8.4e-18 64.2 0.3 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_1 PF01344.23 001257124.1_21025001_1 - 2e-13 49.6 12.1 2.8e-08 33.1 0.0 7.1 6 2 0 6 6 6 2 Kelch motif Kelch_6 PF13964.4 001257124.1_21025001_1 - 2.2e-11 43.5 4.5 3.3e-06 27.1 0.0 5.2 3 2 1 4 4 4 2 Kelch motif Kelch_3 PF13415.4 001257124.1_21025001_1 - 3.9e-10 39.6 0.7 0.00025 21.1 0.0 5.2 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_4 PF13418.4 001257124.1_21025001_1 - 1.9e-09 37.2 0.0 0.00063 19.5 0.0 3.9 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.13 001257124.1_21025001_1 - 3.4e-05 23.5 0.8 0.014 15.2 0.0 4.6 4 1 0 4 4 4 1 Kelch motif DUF3342 PF11822.6 001257124.1_21025001_1 - 0.0053 16.8 0.0 0.01 15.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) PT-TG PF14449.4 001257124.1_21025001_1 - 0.14 11.9 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 Pre-toxin TG WD40 PF00400.30 001206428.1_06524001_1 - 2e-15 56.7 17.8 7.7e-05 23.3 0.1 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001206428.1_06524001_1 - 0.00012 22.2 0.0 2 8.6 0.0 3.6 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 001206428.1_06524001_1 - 0.002 17.9 0.0 0.5 10.1 0.0 2.8 2 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Filament PF00038.19 001346237.1_21025001_2 - 1.7e-107 359.5 29.8 2e-107 359.3 29.8 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001346237.1_21025001_2 - 1.3e-29 103.3 50.6 5.8e-20 72.0 4.2 3.2 2 1 1 3 3 3 2 Keratin type II head TPR_MLP1_2 PF07926.10 001346237.1_21025001_2 - 2e-06 27.8 25.9 0.00018 21.4 10.6 3.4 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.7 001346237.1_21025001_2 - 3.3e-05 23.8 23.2 0.0017 18.2 6.1 2.8 2 1 1 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.9 001346237.1_21025001_2 - 6.3e-05 21.9 25.5 0.0037 16.0 7.1 2.9 1 1 1 2 2 2 2 Spc7 kinetochore protein Tropomyosin_1 PF12718.5 001346237.1_21025001_2 - 0.00042 20.3 25.8 0.001 19.0 8.3 3.2 2 1 1 3 3 3 2 Tropomyosin like Taxilin PF09728.7 001346237.1_21025001_2 - 0.0017 17.6 17.8 0.032 13.4 17.8 2.3 1 1 0 1 1 1 1 Myosin-like coiled-coil protein DUF1664 PF07889.10 001346237.1_21025001_2 - 0.003 17.4 9.7 0.4 10.5 0.0 3.8 3 1 0 3 3 3 1 Protein of unknown function (DUF1664) zf-C4H2 PF10146.7 001346237.1_21025001_2 - 0.0032 17.6 1.4 0.1 12.8 0.0 2.8 3 0 0 3 3 3 1 Zinc finger-containing protein Alanine_zipper PF11839.6 001346237.1_21025001_2 - 0.0033 17.5 1.8 0.0033 17.5 1.8 2.2 2 0 0 2 2 2 1 Alanine-zipper, major outer membrane lipoprotein DUF4164 PF13747.4 001346237.1_21025001_2 - 0.0045 17.1 10.3 0.42 10.8 0.5 2.8 2 1 0 2 2 2 2 Domain of unknown function (DUF4164) ADIP PF11559.6 001346237.1_21025001_2 - 0.0082 16.1 26.2 0.26 11.2 5.1 3.6 2 2 1 3 3 3 3 Afadin- and alpha -actinin-Binding IncA PF04156.12 001346237.1_21025001_2 - 0.0089 15.7 1.6 0.0089 15.7 1.6 3.8 1 1 2 3 3 3 1 IncA protein LPP PF04728.11 001346237.1_21025001_2 - 0.017 15.3 5.5 0.27 11.5 1.1 3.4 4 0 0 4 4 3 0 Lipoprotein leucine-zipper AAA_13 PF13166.4 001346237.1_21025001_2 - 0.02 13.5 14.2 0.005 15.4 11.0 1.5 1 1 0 1 1 1 0 AAA domain Jnk-SapK_ap_N PF09744.7 001346237.1_21025001_2 - 0.023 14.8 1.2 0.023 14.8 1.2 3.3 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 T3SSipB PF16535.3 001346237.1_21025001_2 - 0.031 14.6 5.4 12 6.2 0.0 2.4 2 0 0 2 2 2 0 Type III cell invasion protein SipB TSC22 PF01166.16 001346237.1_21025001_2 - 0.033 14.4 9.1 3.2 8.0 1.0 3.7 3 0 0 3 3 3 0 TSC-22/dip/bun family ATG16 PF08614.9 001346237.1_21025001_2 - 0.035 14.1 27.0 0.5 10.4 5.6 3.3 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) DUF1635 PF07795.9 001346237.1_21025001_2 - 0.044 13.6 2.5 0.17 11.7 2.5 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) COG2 PF06148.9 001346237.1_21025001_2 - 0.091 12.7 13.1 0.23 11.4 0.2 3.3 3 1 0 3 3 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4407 PF14362.4 001346237.1_21025001_2 - 0.12 11.6 19.1 0.37 10.0 4.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Reo_sigmaC PF04582.10 001346237.1_21025001_2 - 0.12 11.6 7.8 5 6.3 0.4 2.9 1 1 2 3 3 3 0 Reovirus sigma C capsid protein GAS PF13851.4 001346237.1_21025001_2 - 0.12 11.6 24.7 0.017 14.4 6.2 3.2 1 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding FlaC_arch PF05377.9 001346237.1_21025001_2 - 0.17 12.1 8.8 4 7.8 0.2 3.7 4 0 0 4 4 2 0 Flagella accessory protein C (FlaC) DUF4140 PF13600.4 001346237.1_21025001_2 - 0.21 11.9 13.0 9.9 6.5 0.0 3.9 3 1 1 4 4 3 0 N-terminal domain of unknown function (DUF4140) ERM PF00769.17 001346237.1_21025001_2 - 0.26 11.0 20.1 0.2 11.3 10.3 2.3 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Spc24 PF08286.9 001346237.1_21025001_2 - 0.36 10.9 21.2 0.25 11.4 3.5 4.1 3 2 1 4 4 4 0 Spc24 subunit of Ndc80 Golgin_A5 PF09787.7 001346237.1_21025001_2 - 0.49 9.7 22.4 0.88 8.8 3.5 2.8 1 1 1 3 3 3 0 Golgin subfamily A member 5 SOGA PF11365.6 001346237.1_21025001_2 - 0.54 11.3 13.0 0.73 10.9 0.4 3.7 4 0 0 4 4 3 0 Protein SOGA BLOC1_2 PF10046.7 001346237.1_21025001_2 - 0.57 10.4 9.3 2.1 8.6 0.3 3.4 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TSNAXIP1_N PF15739.3 001346237.1_21025001_2 - 0.67 10.2 13.8 0.13 12.5 3.3 3.1 3 0 0 3 3 3 0 Translin-associated factor X-interacting N-terminus bZIP_1 PF00170.19 001346237.1_21025001_2 - 0.92 9.5 12.5 6.7 6.8 0.2 4.0 4 1 0 4 4 3 0 bZIP transcription factor Muted PF14942.4 001346237.1_21025001_2 - 0.99 9.6 16.9 0.044 14.0 4.5 2.7 2 2 0 2 2 2 0 Organelle biogenesis, Muted-like protein APG6 PF04111.10 001346237.1_21025001_2 - 1.3 8.2 25.1 2 7.6 6.4 2.5 1 1 0 2 2 2 0 Autophagy protein Apg6 DUF948 PF06103.9 001346237.1_21025001_2 - 1.7 8.8 7.7 1.3 9.2 0.9 3.2 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Cep57_CLD_2 PF14197.4 001346237.1_21025001_2 - 2.1 8.4 12.6 1.3 9.0 3.1 3.5 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 ZapB PF06005.10 001346237.1_21025001_2 - 2.5 8.5 21.3 4.8 7.6 3.8 3.6 2 2 1 3 3 3 0 Cell division protein ZapB Syntaxin-6_N PF09177.9 001346237.1_21025001_2 - 2.6 8.5 15.2 7 7.2 0.6 3.7 2 2 1 3 3 3 0 Syntaxin 6, N-terminal DUF5082 PF16888.3 001346237.1_21025001_2 - 3.5 7.9 19.2 3.5 7.9 2.8 3.8 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) Keratin_2_tail PF16210.3 001346237.1_21025001_2 - 4.2 7.5 61.8 0.077 13.1 20.6 2.2 2 0 0 2 2 2 0 Keratin type II cytoskeletal 1 tail DUF3450 PF11932.6 001346237.1_21025001_2 - 4.5 6.4 25.7 0.35 10.0 7.4 3.8 2 2 1 4 4 4 0 Protein of unknown function (DUF3450) COG5 PF10392.7 001346237.1_21025001_2 - 4.6 7.3 12.0 0.2 11.7 3.8 2.6 3 1 0 3 3 2 0 Golgi transport complex subunit 5 Gp58 PF07902.9 001346237.1_21025001_2 - 5.1 5.3 11.3 2.3 6.4 7.7 1.7 1 1 1 2 2 2 0 gp58-like protein TBPIP PF07106.11 001346237.1_21025001_2 - 5.5 6.6 17.7 0.72 9.5 4.0 3.1 2 2 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TMF_TATA_bd PF12325.6 001346237.1_21025001_2 - 7.2 6.7 20.5 1.4 9.1 1.5 4.2 1 1 1 4 4 4 0 TATA element modulatory factor 1 TATA binding 7tm_1 PF00001.19 001309180.1_21023001_3 - 6.5e-50 169.7 30.5 9.4e-50 169.2 30.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001309180.1_21023001_3 - 0.0012 18.1 21.4 0.0012 18.1 21.4 2.2 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx MscS_TM PF12794.5 001309180.1_21023001_3 - 0.019 13.7 5.0 0.054 12.2 0.3 2.2 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 DUF2371 PF10177.7 001257165.1_21024001_2 - 3.4e-63 211.9 0.0 5.4e-63 211.2 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2371) Lectin_C PF00059.19 001281814.1_21022001_2 - 2.4e-17 63.5 2.2 2.4e-17 63.5 2.2 1.7 2 0 0 2 2 2 1 Lectin C-type domain Ly49 PF08391.8 001281814.1_21022001_2 - 0.00033 20.9 4.7 0.00068 19.8 4.7 1.6 1 1 0 1 1 1 1 Ly49-like protein, N-terminal region UL45 PF05473.10 001281814.1_21022001_2 - 0.21 11.0 2.6 0.42 10.1 2.6 1.4 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Cathelicidins PF00666.15 001081930.2_21022001_1 - 8.5e-47 157.5 0.1 1.1e-46 157.1 0.1 1.2 1 0 0 1 1 1 1 Cathelicidin Spp-24 PF07448.9 001081930.2_21022001_1 - 0.0039 17.2 0.1 0.007 16.4 0.1 1.3 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Cystatin PF00031.19 001081930.2_21022001_1 - 0.069 13.3 0.4 0.88 9.8 0.4 2.2 1 1 0 1 1 1 0 Cystatin domain NMDAR2_C PF10565.7 001192921.2_06529001_1 - 1.5e-233 777.4 5.9 1.8e-233 777.1 5.9 1.1 1 0 0 1 1 1 1 N-methyl D-aspartate receptor 2B3 C-terminus Lig_chan PF00060.24 001192921.2_06529001_1 - 6.2e-34 116.8 0.1 1.5e-33 115.6 0.1 1.7 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 001192921.2_06529001_1 - 5.5e-30 103.8 0.1 2.5e-29 101.6 0.1 2.0 1 1 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 001192921.2_06529001_1 - 5.4e-24 84.7 0.0 9.5e-24 83.9 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 ANF_receptor PF01094.26 001192921.2_06529001_1 - 1.8e-13 50.2 0.1 1.5e-11 43.9 0.1 2.2 1 1 0 1 1 1 1 Receptor family ligand binding region Mut7-C PF01927.14 001192921.2_06529001_1 - 0.21 11.5 2.1 2.1 8.3 0.6 2.3 2 0 0 2 2 2 0 Mut7-C RNAse domain DUF4013 PF13197.4 001192921.2_06529001_1 - 2.4 7.9 6.6 2.5 7.8 4.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4013) Pkinase PF00069.23 001309468.1_21029001_3 - 2.4e-69 233.5 0.0 3.7e-69 232.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001309468.1_21029001_3 - 5.3e-32 111.0 0.0 7.4e-32 110.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 001309468.1_21029001_3 - 9.6e-27 92.5 23.3 8.3e-14 51.1 3.1 3.0 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) PH PF00169.27 001309468.1_21029001_3 - 2.7e-10 40.5 0.5 3.9e-08 33.6 0.1 2.9 2 1 1 3 3 3 1 PH domain Kinase-like PF14531.4 001309468.1_21029001_3 - 4.5e-06 26.1 0.0 1.7e-05 24.2 0.0 1.8 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.12 001309468.1_21029001_3 - 5.7e-05 22.4 0.0 0.0001 21.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family C1_2 PF03107.14 001309468.1_21029001_3 - 0.0068 16.6 23.3 0.0093 16.1 1.8 2.9 3 0 0 3 3 3 2 C1 domain zf-RING_9 PF13901.4 001309468.1_21029001_3 - 0.096 12.5 12.2 1.9 8.3 0.3 2.3 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon FYVE_2 PF02318.14 001309468.1_21029001_3 - 4.8 7.3 10.6 5.2 7.2 5.3 2.4 2 0 0 2 2 2 0 FYVE-type zinc finger PHD PF00628.27 001309468.1_21029001_3 - 6.4 6.6 20.1 4 7.3 3.2 2.6 2 0 0 2 2 2 0 PHD-finger Mab-21 PF03281.12 001257130.1_21024001_1 - 1.5e-98 329.7 0.0 2.1e-98 329.2 0.0 1.2 1 0 0 1 1 1 1 Mab-21 protein Transferrin PF00405.15 001081946.2_21025001_1 - 1.2e-264 875.8 8.6 1.4e-180 599.5 0.1 2.0 2 0 0 2 2 2 2 Transferrin Phosphonate-bd PF12974.5 001081946.2_21025001_1 - 9.1e-12 44.9 0.0 5.7e-05 22.7 0.0 2.8 3 1 0 3 3 3 2 ABC transporter, phosphonate, periplasmic substrate-binding protein 7tm_1 PF00001.19 001257099.1_21023001_1 - 1.9e-63 214.1 22.7 2.5e-63 213.7 22.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001257099.1_21023001_1 - 3.5e-12 46.1 18.5 4.7e-12 45.7 18.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.7 001257099.1_21023001_1 - 1.1e-08 34.6 10.0 1.1e-08 34.6 10.0 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.7 001257099.1_21023001_1 - 7.3e-07 28.6 10.8 7.3e-07 28.6 10.8 2.1 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001257099.1_21023001_1 - 1.1e-05 25.2 18.0 1.7e-05 24.6 18.0 1.3 1 1 0 1 1 1 1 Olfactory receptor T2SSM PF04612.10 001257099.1_21023001_1 - 0.024 14.6 0.2 0.069 13.1 0.2 1.8 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M Piezo_RRas_bdg PF12166.6 001257099.1_21023001_1 - 0.029 13.5 0.4 0.2 10.7 0.1 2.1 2 0 0 2 2 2 0 Piezo non-specific cation channel, R-Ras-binding domain RnaseA PF00074.18 001309410.1_21021001_1 - 7.6e-27 94.1 3.7 9.6e-27 93.8 3.7 1.0 1 0 0 1 1 1 1 Pancreatic ribonuclease MFS_1 PF07690.14 001205974.1_06525001_2 - 4.3e-59 200.1 36.0 1.3e-58 198.5 29.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily SH3_1 PF00018.26 001283084.1_21022001_2 - 1e-30 104.9 0.5 4e-16 58.2 0.1 2.7 3 0 0 3 3 3 2 SH3 domain SH3_9 PF14604.4 001283084.1_21022001_2 - 3.6e-29 100.2 0.1 9.9e-15 54.0 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH2 PF00017.22 001283084.1_21022001_2 - 1e-24 86.2 0.0 1.8e-24 85.5 0.0 1.4 1 0 0 1 1 1 1 SH2 domain SH3_2 PF07653.15 001283084.1_21022001_2 - 1.7e-24 85.1 0.0 5.2e-12 45.1 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH2_2 PF14633.4 001283084.1_21022001_2 - 0.0042 16.4 0.0 0.0064 15.8 0.0 1.3 1 0 0 1 1 1 1 SH2 domain hSH3 PF14603.4 001283084.1_21022001_2 - 0.0058 17.0 0.0 0.039 14.4 0.0 2.1 2 0 0 2 2 2 1 Helically-extended SH3 domain DUF5093 PF17011.3 001283084.1_21022001_2 - 0.018 15.2 0.0 0.039 14.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5093) SH3_3 PF08239.9 001283084.1_21022001_2 - 0.037 14.2 0.0 0.077 13.1 0.0 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain SH3_4 PF06347.11 001283084.1_21022001_2 - 0.039 13.6 0.0 0.073 12.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial SH3 domain MM_CoA_mutase PF01642.20 001309313.1_21025001_2 - 1.1e-237 789.5 0.0 1.4e-237 789.2 0.0 1.1 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase B12-binding PF02310.17 001309313.1_21025001_2 - 1.2e-14 54.2 0.1 3.5e-14 52.8 0.1 1.9 1 0 0 1 1 1 1 B12 binding domain PDZ PF00595.22 001242477.1_21022001_1 - 5.2e-20 71.5 2.9 5.1e-12 45.9 0.1 2.4 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001242477.1_21022001_1 - 3.1e-12 46.5 0.2 3e-07 30.5 0.0 2.4 1 1 1 2 2 2 2 PDZ domain FANCM-MHF_bd PF16783.3 001104976.2_06529001_1 - 2.4e-49 166.1 3.3 2.4e-49 166.1 3.3 2.7 2 0 0 2 2 2 1 FANCM to MHF binding domain Helicase_C PF00271.29 001104976.2_06529001_1 - 4.1e-20 72.1 0.4 6e-19 68.3 0.0 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.13 001104976.2_06529001_1 - 2.5e-18 66.5 0.1 1.5e-17 64.0 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.27 001104976.2_06529001_1 - 2.4e-16 59.8 0.0 6.2e-16 58.5 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase ERCC4 PF02732.13 001104976.2_06529001_1 - 5.6e-10 39.5 1.5 1.4e-09 38.1 0.4 2.4 2 0 0 2 2 2 1 ERCC4 domain HHH_2 PF12826.5 001104976.2_06529001_1 - 0.024 14.6 0.0 0.053 13.5 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif CENP-K PF11802.6 001309305.1_21024001_2 - 9.6e-123 408.8 24.8 1.2e-122 408.5 24.8 1.1 1 0 0 1 1 1 1 Centromere-associated protein K GSCFA PF08885.9 001309305.1_21024001_2 - 0.052 13.1 1.6 0.082 12.4 1.6 1.3 1 0 0 1 1 1 0 GSCFA family 4HB_MCP_1 PF12729.5 001309305.1_21024001_2 - 3 7.2 9.5 0.5 9.7 5.0 2.0 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction 7TMR-HDED PF07697.9 001309305.1_21024001_2 - 3.9 7.4 8.1 6 6.8 8.1 1.3 1 0 0 1 1 1 0 7TM-HD extracellular Exonuc_VII_L PF02601.13 001309305.1_21024001_2 - 5.6 6.3 13.8 15 4.9 13.8 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit mTERF PF02536.12 001191174.1_06524001_1 - 3.9e-23 81.8 8.8 6.7e-23 81.0 8.4 1.6 1 1 0 1 1 1 1 mTERF RabGAP-TBC PF00566.16 001309184.1_21026001_1 - 2.1e-58 197.4 4.0 4.8e-58 196.2 4.0 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF3694 PF12473.6 001309184.1_21026001_1 - 2.2e-39 135.4 0.1 7.2e-39 133.7 0.0 2.0 2 0 0 2 2 2 1 Kinesin protein PID PF00640.21 001309184.1_21026001_1 - 0.00023 21.1 1.2 0.00038 20.4 0.1 2.0 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 001309184.1_21026001_1 - 0.00094 19.2 0.0 0.0024 17.9 0.0 1.8 1 0 0 1 1 1 1 Phosphotyrosine-binding domain DUF436 PF04260.10 001309184.1_21026001_1 - 0.12 11.8 0.1 0.23 10.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF436) EamA PF00892.18 001256950.1_21023001_1 - 9.9e-18 64.5 35.1 3.2e-10 40.2 7.3 2.3 3 0 0 3 3 3 2 EamA-like transporter family eIF_4EBP PF05456.9 001204104.1_21022001_3 - 2.6e-36 123.9 0.8 3.5e-36 123.5 0.8 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Pou PF00157.15 001257184.1_21023001_2 - 1.2e-38 130.8 0.3 2e-38 130.1 0.3 1.4 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 001257184.1_21023001_2 - 2.7e-18 65.4 1.5 8.1e-18 63.9 0.3 2.1 2 0 0 2 2 2 1 Homeobox domain HTH_31 PF13560.4 001257184.1_21023001_2 - 0.018 15.3 0.0 0.071 13.3 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain Homeobox_KN PF05920.9 001257184.1_21023001_2 - 0.054 13.3 0.2 0.16 11.7 0.0 1.9 2 0 0 2 2 2 0 Homeobox KN domain Pkinase_Tyr PF07714.15 001204809.1_21027001_2 - 1.5e-57 194.7 0.0 4.9e-57 193.0 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Ank_2 PF12796.5 001204809.1_21027001_2 - 2.1e-55 185.1 7.9 3.2e-14 53.1 1.0 6.3 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.28 001204809.1_21027001_2 - 8.2e-48 158.7 27.0 2e-06 27.8 0.0 11.2 12 0 0 12 12 11 8 Ankyrin repeat Pkinase PF00069.23 001204809.1_21027001_2 - 2.2e-46 158.2 0.0 5.4e-46 157.0 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.4 001204809.1_21027001_2 - 3.5e-46 154.9 24.3 9.2e-13 48.3 0.4 8.3 4 4 5 9 9 9 9 Ankyrin repeats (many copies) Ank_3 PF13606.4 001204809.1_21027001_2 - 1.7e-39 129.2 17.6 0.00022 21.3 0.2 11.6 12 0 0 12 12 12 8 Ankyrin repeat Ank_5 PF13857.4 001204809.1_21027001_2 - 2.1e-38 129.6 11.1 3.5e-06 27.1 0.5 9.1 3 3 5 9 9 9 7 Ankyrin repeats (many copies) APH PF01636.21 001204809.1_21027001_2 - 0.053 13.3 0.0 0.088 12.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.12 001204809.1_21027001_2 - 0.06 12.6 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 001204809.1_21027001_2 - 0.078 12.4 1.5 0.16 11.4 0.1 1.9 2 0 0 2 2 2 0 RIO1 family Kinase-like PF14531.4 001204809.1_21027001_2 - 0.19 10.9 0.0 0.32 10.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like 7tm_1 PF00001.19 001257081.1_21023001_1 - 9.9e-72 241.2 14.9 1.3e-71 240.9 14.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001257081.1_21023001_1 - 2.6e-11 43.2 11.3 1.1e-10 41.2 11.3 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001257081.1_21023001_1 - 1.6e-06 27.5 12.5 1.6e-06 27.5 12.5 2.7 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Glyco_hydro_1 PF00232.16 001192493.2_06524001_1 - 7.1e-157 522.3 1.7 8.3e-157 522.1 1.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Prp19 PF08606.9 001192493.2_06524001_3 - 0.19 11.6 0.0 0.32 10.9 0.0 1.2 1 0 0 1 1 1 0 Prp19/Pso4-like Alg6_Alg8 PF03155.13 001309344.1_21024001_2 - 8.8e-171 568.9 32.3 1e-170 568.6 32.3 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family UBN_AB PF14075.4 001205922.1_06528001_1 - 3.8e-82 275.0 4.8 3.8e-82 275.0 4.8 2.7 2 1 0 2 2 2 1 Ubinuclein conserved middle domain HUN PF08729.8 001205922.1_06528001_1 - 5e-20 71.1 0.7 1.5e-19 69.5 0.7 1.9 1 0 0 1 1 1 1 HPC2 and ubinuclein domain Homeobox PF00046.27 001257156.1_21026001_1 - 2.4e-26 91.2 12.9 5.6e-07 29.2 0.1 4.4 4 0 0 4 4 4 4 Homeobox domain Homeobox_KN PF05920.9 001257156.1_21026001_1 - 4.9e-15 55.0 7.1 0.0025 17.5 0.0 4.9 4 0 0 4 4 4 4 Homeobox KN domain Homez PF11569.6 001257156.1_21026001_1 - 1.9e-07 30.3 2.3 0.32 10.3 0.1 5.3 5 0 0 5 5 5 2 Homeodomain leucine-zipper encoding, Homez DUF3505 PF12013.6 001257156.1_21026001_1 - 0.00021 21.6 0.3 0.057 13.7 0.0 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3505) zf-H2C2_5 PF13909.4 001257156.1_21026001_1 - 0.0046 16.5 5.9 0.11 12.1 0.5 2.6 2 0 0 2 2 2 2 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 001257156.1_21026001_1 - 0.027 14.8 7.0 1.3 9.5 0.6 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type Phage_AlpA PF05930.10 001257156.1_21026001_1 - 0.11 12.2 0.1 14 5.5 0.0 2.8 3 0 0 3 3 3 0 Prophage CP4-57 regulatory protein (AlpA) zf-C2H2_2 PF12756.5 001257156.1_21026001_1 - 0.19 12.0 2.7 0.71 10.1 0.1 2.7 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-H2C2_2 PF13465.4 001257156.1_21026001_1 - 0.23 11.9 6.1 5.4 7.5 0.5 3.4 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_4 PF13894.4 001257156.1_21026001_1 - 3 8.8 5.7 7.6 7.5 0.5 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger SPARC_Ca_bdg PF10591.7 001143953.2_21025001_2 - 4.7e-39 133.1 0.1 1.3e-38 131.6 0.1 1.8 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Kazal_1 PF00050.19 001143953.2_21025001_2 - 4.1e-13 49.0 4.4 4.1e-13 49.0 4.4 2.4 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.13 001143953.2_21025001_2 - 6.4e-11 42.1 2.2 1.6e-10 40.8 2.2 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain FOLN PF09289.8 001143953.2_21025001_2 - 3.2e-09 36.6 7.8 8.5e-09 35.3 7.8 1.8 1 0 0 1 1 1 1 Follistatin/Osteonectin-like EGF domain hEGF PF12661.5 001143953.2_21025001_2 - 2 9.1 7.1 0.36 11.5 2.5 2.3 2 0 0 2 2 2 0 Human growth factor-like EGF Interferon PF00143.17 001143795.1_21022001_1 - 1.9e-37 128.8 4.4 5.1e-37 127.4 4.4 1.6 1 1 0 1 1 1 1 Interferon alpha/beta domain DASH_Dad4 PF08650.8 001143795.1_21022001_1 - 0.11 12.3 0.1 0.23 11.4 0.1 1.4 1 0 0 1 1 1 0 DASH complex subunit Dad4 Glyco_hydro_15 PF00723.19 001163825.1_21028001_1 - 8.6e-109 364.1 0.0 1.1e-108 363.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 PID PF00640.21 001242550.1_21026001_3 - 9.5e-09 35.3 0.1 1.6e-08 34.6 0.1 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) zf-RING_2 PF13639.4 001309332.1_21028001_2 - 7.7e-10 38.8 8.9 7.7e-10 38.8 8.9 3.1 3 1 0 3 3 1 1 Ring finger domain zf-rbx1 PF12678.5 001309332.1_21028001_2 - 6.9e-09 35.7 6.6 6.9e-09 35.7 6.6 2.1 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.4 001309332.1_21028001_2 - 8.8e-07 28.5 9.2 8.8e-07 28.5 9.2 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001309332.1_21028001_2 - 1.2e-06 28.2 8.2 3.5e-06 26.6 8.2 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001309332.1_21028001_2 - 2.7e-06 27.0 5.7 6.9e-06 25.7 5.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.3 001309332.1_21028001_2 - 8.1e-05 22.1 6.2 8.1e-05 22.1 6.2 2.7 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_5 PF14634.4 001309332.1_21028001_2 - 0.00011 21.9 5.6 0.00011 21.9 5.6 2.7 2 1 0 2 2 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.4 001309332.1_21028001_2 - 0.0011 18.8 6.2 0.0032 17.3 6.2 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.5 001309332.1_21028001_2 - 0.0058 16.5 1.9 0.0058 16.5 1.9 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.3 001309332.1_21028001_2 - 0.044 13.3 3.9 0.12 11.9 3.9 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Reo_sigmaC PF04582.10 001309332.1_21028001_2 - 0.19 11.0 1.1 0.8 8.9 0.3 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein 7tm_1 PF00001.19 001257073.1_21024001_1 - 1.2e-80 270.4 4.9 1.8e-80 269.9 4.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001257073.1_21024001_1 - 2.5e-09 36.8 6.1 2.5e-09 36.8 6.1 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001257073.1_21024001_1 - 2.6e-06 27.2 10.8 1e-05 25.3 3.5 2.3 2 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001257073.1_21024001_1 - 3.6e-05 23.1 11.1 3.6e-05 23.1 11.1 2.3 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Ank_2 PF12796.5 001205056.1_21025001_3 - 4.5e-52 174.4 1.3 4.3e-15 55.9 0.1 5.3 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001205056.1_21025001_3 - 3e-46 155.1 3.5 6.1e-10 39.3 0.1 7.1 5 2 2 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.28 001205056.1_21025001_3 - 2.5e-40 135.1 8.4 2e-06 27.9 0.0 10.7 9 2 2 11 11 11 7 Ankyrin repeat Ank_3 PF13606.4 001205056.1_21025001_3 - 3.6e-35 115.9 8.0 9.7e-05 22.4 0.0 10.7 11 0 0 11 11 11 6 Ankyrin repeat Ank_5 PF13857.4 001205056.1_21025001_3 - 9e-27 92.6 10.0 4e-07 30.1 0.4 7.9 3 2 6 9 9 9 7 Ankyrin repeats (many copies) SOCS_box PF07525.14 001205056.1_21025001_3 - 1.5e-11 44.3 5.8 3.5e-11 43.1 5.8 1.7 1 0 0 1 1 1 1 SOCS box Defensin_propep PF00879.16 001166077.1_21021001_1 - 2.2e-19 69.4 3.0 3.1e-19 68.9 3.0 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166077.1_21021001_1 - 0.00011 22.5 16.7 0.00017 21.9 16.7 1.3 1 0 0 1 1 1 1 Mammalian defensin DUF1049 PF06305.9 001166077.1_21021001_2 - 3.8 7.3 6.2 3.4 7.4 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1049) LRR_8 PF13855.4 001257131.1_21025001_1 - 3e-29 100.4 16.5 1.2e-13 50.4 0.1 2.7 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.5 001257131.1_21025001_1 - 2.4e-12 46.7 5.6 0.00091 19.4 1.5 3.5 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) I-set PF07679.14 001257131.1_21025001_1 - 9.3e-08 31.9 0.0 2e-07 30.9 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin I-set domain LRR_9 PF14580.4 001257131.1_21025001_1 - 1.2e-06 28.0 0.1 0.012 15.0 0.0 2.1 1 1 1 2 2 2 2 Leucine-rich repeat Ig_3 PF13927.4 001257131.1_21025001_1 - 3.7e-06 27.3 0.0 7.5e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001257131.1_21025001_1 - 0.00083 19.4 0.0 0.0024 17.9 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain LRR_5 PF13306.4 001257131.1_21025001_1 - 0.00089 19.1 0.0 0.0022 17.8 0.0 1.5 1 1 0 1 1 1 1 Leucine rich repeats (6 copies) LRRCT PF01463.22 001257131.1_21025001_1 - 0.035 14.5 0.3 0.035 14.5 0.3 3.1 3 0 0 3 3 2 0 Leucine rich repeat C-terminal domain LRR_6 PF13516.4 001257131.1_21025001_1 - 0.045 13.7 11.9 0.16 12.0 1.0 4.9 5 0 0 5 5 5 0 Leucine Rich repeat TPKR_C2 PF16920.3 001257131.1_21025001_1 - 0.085 12.9 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Tyrosine-protein kinase receptor C2 Ig-like domain LRR_1 PF00560.31 001257131.1_21025001_1 - 0.12 12.8 10.6 5.4 7.8 0.8 6.2 6 1 0 6 6 6 0 Leucine Rich Repeat Ig_2 PF13895.4 001257131.1_21025001_1 - 0.13 12.5 0.0 1 9.6 0.0 2.4 1 1 0 1 1 1 0 Immunoglobulin domain THOC7 PF05615.11 001308953.1_21023001_3 - 1e-39 135.7 6.0 6.3e-39 133.1 0.2 2.1 1 1 1 2 2 2 2 Tho complex subunit 7 UPF0193 PF05250.9 001308953.1_21023001_3 - 0.0065 16.2 5.3 0.01 15.5 5.3 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0193) DASH_Dad2 PF08654.8 001308953.1_21023001_3 - 0.049 13.9 0.7 0.096 13.0 0.7 1.5 1 0 0 1 1 1 0 DASH complex subunit Dad2 EcoEI_R_C PF08463.8 001308953.1_21023001_3 - 0.28 11.1 4.8 0.45 10.5 4.8 1.2 1 0 0 1 1 1 0 EcoEI R protein C-terminal COG2 PF06148.9 001308953.1_21023001_3 - 2.7 7.9 7.2 1.7 8.6 0.9 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Spc7 PF08317.9 001308953.1_21023001_3 - 2.9 6.5 15.0 0.96 8.1 2.1 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF1664 PF07889.10 001308953.1_21023001_3 - 5.5 6.9 6.8 10 6.0 3.0 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) AATF-Che1 PF13339.4 001308953.1_21023001_3 - 8.9 6.9 7.9 2.6 8.6 3.6 1.9 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor Serpin PF00079.18 001143952.1_21025001_1 - 1.2e-123 413.0 10.4 1.7e-123 412.5 10.1 1.4 2 0 0 2 2 2 1 Serpin (serine protease inhibitor) Defensin_propep PF00879.16 001166089.1_21022001_1 - 1.4e-23 82.8 2.3 1.9e-23 82.4 2.3 1.2 1 0 0 1 1 1 1 Defensin propeptide PepSY_2 PF13670.4 001166089.1_21022001_1 - 0.16 11.8 0.1 0.23 11.3 0.1 1.2 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain SRTM1 PF15872.3 001166089.1_21022001_2 - 6 6.9 6.7 10 6.2 6.7 1.3 1 0 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 WD40 PF00400.30 001206576.1_06529001_1 - 6.5e-61 200.7 92.1 8.2e-06 26.3 0.3 27.8 30 0 0 30 30 30 15 WD domain, G-beta repeat HELP PF03451.12 001206576.1_06529001_1 - 1e-56 188.6 2.5 1.9e-18 65.9 0.3 3.4 3 0 0 3 3 3 3 HELP motif ANAPC4_WD40 PF12894.5 001206576.1_06529001_1 - 1.1e-34 118.5 5.2 4e-08 33.3 0.0 13.3 8 3 3 12 12 12 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 001206576.1_06529001_1 - 4.4e-06 25.8 2.0 0.26 10.1 0.0 6.1 4 3 3 7 7 7 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.9 001206576.1_06529001_1 - 7.4e-05 21.6 0.0 0.17 10.5 0.0 4.0 4 0 0 4 4 4 2 Nup133 N terminal like Frtz PF11768.6 001206576.1_06529001_1 - 7.8e-05 21.1 0.0 0.75 7.9 0.0 4.1 3 2 1 4 4 4 2 WD repeat-containing and planar cell polarity effector protein Fritz Cytochrom_D1 PF02239.14 001206576.1_06529001_1 - 0.00083 17.8 7.6 1.3 7.3 0.0 5.8 6 1 1 7 7 7 2 Cytochrome D1 heme domain Nup160 PF11715.6 001206576.1_06529001_1 - 0.084 11.3 0.0 6.6 5.1 0.0 3.2 3 0 0 3 3 3 0 Nucleoporin Nup120/160 Xin PF08043.10 001256977.1_21029001_1 - 2.7e-89 290.4 50.7 7.6e-09 34.8 0.2 15.9 16 0 0 16 16 16 15 Xin repeat PAS_3 PF08447.10 001206026.1_06527001_3 - 9.3e-20 70.6 0.1 8.7e-13 48.2 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS PF00989.23 001206026.1_06527001_3 - 1.2e-15 57.4 0.0 2.1e-14 53.3 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS_11 PF14598.4 001206026.1_06527001_3 - 5.3e-13 48.9 1.1 8.9e-10 38.6 0.0 3.1 3 0 0 3 3 3 2 PAS domain HLH PF00010.24 001206026.1_06527001_3 - 1.4e-05 24.9 0.1 2.8e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_4 PF08448.8 001206026.1_06527001_3 - 0.0044 17.1 0.0 0.075 13.2 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.5 001206026.1_06527001_3 - 0.014 15.5 0.0 0.13 12.4 0.0 2.4 2 0 0 2 2 2 0 PAS domain V1R PF03402.12 001167524.1_21022001_1 - 1.3e-19 70.8 10.3 1.8e-19 70.3 10.3 1.2 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167524.1_21022001_1 - 3.3e-14 52.6 13.0 4.4e-14 52.2 13.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167524.1_21022001_1 - 3.1e-06 26.5 12.9 4.6e-06 25.9 12.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1129 PF06570.9 001167524.1_21022001_1 - 0.16 11.3 1.2 0.29 10.5 1.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Filament PF00038.19 001346172.1_21024001_2 - 2.5e-110 368.8 36.8 2.9e-110 368.6 36.8 1.0 1 0 0 1 1 1 1 Intermediate filament protein Gp58 PF07902.9 001346172.1_21024001_2 - 0.0015 16.9 9.3 0.0015 16.9 9.3 1.5 1 1 1 2 2 2 1 gp58-like protein Lzipper-MIP1 PF14389.4 001346172.1_21024001_2 - 0.0095 16.0 4.4 0.0095 16.0 4.4 4.1 3 2 0 3 3 3 1 Leucine-zipper of ternary complex factor MIP1 TPR_MLP1_2 PF07926.10 001346172.1_21024001_2 - 0.015 15.2 2.6 0.015 15.2 2.6 4.0 2 2 2 4 4 4 0 TPR/MLP1/MLP2-like protein Baculo_PEP_C PF04513.10 001346172.1_21024001_2 - 0.077 12.9 19.3 0.39 10.6 11.9 3.1 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4677 PF15726.3 001346172.1_21024001_2 - 0.091 12.8 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4677) TNF PF00229.16 001346172.1_21024001_2 - 0.2 11.5 2.2 1.6 8.5 0.1 2.8 3 0 0 3 3 3 0 TNF(Tumour Necrosis Factor) family Uso1_p115_C PF04871.11 001346172.1_21024001_2 - 0.39 10.9 20.4 0.78 10.0 5.5 2.9 2 2 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region NYD-SP28_assoc PF14775.4 001346172.1_21024001_2 - 0.76 9.8 10.6 3.4 7.7 1.0 3.9 3 0 0 3 3 3 0 Sperm tail C-terminal domain Spc7 PF08317.9 001346172.1_21024001_2 - 1.8 7.2 30.7 1.1 7.9 10.6 2.4 1 1 0 2 2 2 0 Spc7 kinetochore protein Jnk-SapK_ap_N PF09744.7 001346172.1_21024001_2 - 2.3 8.3 34.0 1.4 9.0 9.8 3.7 1 1 2 4 4 4 0 JNK_SAPK-associated protein-1 DUF1664 PF07889.10 001346172.1_21024001_2 - 3 7.7 18.0 2.9 7.8 2.0 3.9 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) FliD_C PF07195.10 001346172.1_21024001_2 - 3.3 6.9 9.2 2.5 7.4 5.7 2.2 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus DUF5082 PF16888.3 001346172.1_21024001_2 - 6.1 7.1 21.1 5.8 7.2 8.8 3.9 2 2 1 3 3 3 0 Domain of unknown function (DUF5082) Fib_alpha PF08702.8 001346172.1_21024001_2 - 7 6.7 25.4 4.1 7.4 9.6 3.5 2 2 2 4 4 4 0 Fibrinogen alpha/beta chain family ADIP PF11559.6 001346172.1_21024001_2 - 8.8 6.3 32.8 2.3 8.2 13.3 3.3 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding RA PF00788.21 001242540.1_21023001_2 - 1.3e-12 48.0 0.0 7.4e-12 45.6 0.0 2.2 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain Nore1-SARAH PF16517.3 001242540.1_21023001_2 - 4.1e-12 45.7 5.0 4.1e-12 45.7 5.0 2.1 2 0 0 2 2 2 1 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain PKI PF02827.14 001114518.2_06524001_1 - 3.8e-28 97.4 0.6 7.3e-28 96.4 0.6 1.5 1 0 0 1 1 1 1 cAMP-dependent protein kinase inhibitor Defensin_propep PF00879.16 001166073.1_21021001_1 - 4.6e-21 74.8 1.3 6e-21 74.4 1.3 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166073.1_21021001_1 - 0.00038 20.8 12.1 0.00055 20.3 12.1 1.2 1 0 0 1 1 1 1 Mammalian defensin BTB PF00651.29 001256905.1_21026001_2 - 5e-24 84.5 0.0 9.5e-24 83.6 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 001256905.1_21026001_2 - 1.8e-13 50.1 50.3 3.9e-07 30.1 5.2 10.0 11 0 0 11 11 11 5 Zinc-finger double domain zf-C2H2_4 PF13894.4 001256905.1_21026001_2 - 1.3e-06 28.6 76.5 0.04 14.6 3.5 10.3 10 0 0 10 10 10 7 C2H2-type zinc finger zf-C2H2 PF00096.24 001256905.1_21026001_2 - 2.1e-05 24.6 76.4 0.0038 17.5 3.4 9.6 10 0 0 10 10 10 6 Zinc finger, C2H2 type BolA PF01722.16 001256905.1_21026001_2 - 0.015 15.4 4.5 1.3 9.2 0.0 3.7 3 1 1 4 4 4 0 BolA-like protein Prion PF00377.16 001143798.2_21026001_2 - 1.3e-35 121.7 2.8 1.7e-35 121.2 2.8 1.2 1 0 0 1 1 1 1 Prion/Doppel alpha-helical domain Prion_bPrPp PF11587.6 001143798.2_21026001_2 - 1.2e-17 63.3 1.1 2.4e-17 62.3 1.1 1.5 1 0 0 1 1 1 1 Major prion protein bPrPp - N terminal FGF PF00167.16 001163886.1_21022001_1 - 3.4e-42 143.3 0.0 4.4e-42 143.0 0.0 1.1 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.11 001163886.1_21022001_1 - 1e-05 25.6 0.1 0.012 15.7 0.0 1.5 1 1 1 2 2 2 2 Fascin domain Defensin_propep PF00879.16 001166072.1_21021001_1 - 2.2e-19 69.4 1.4 2.8e-19 69.0 1.4 1.1 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166072.1_21021001_1 - 0.2 12.1 14.9 0.34 11.3 14.9 1.4 1 0 0 1 1 1 0 Mammalian defensin Arf PF00025.19 001301290.1_21027001_3 - 8.1e-62 207.6 0.0 1.1e-61 207.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.8 001301290.1_21027001_3 - 4.1e-09 36.0 0.0 5.8e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.11 001301290.1_21027001_3 - 6.9e-07 29.4 0.0 1.3e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.18 001301290.1_21027001_3 - 1.4e-06 27.6 0.0 4.6e-05 22.6 0.0 2.2 1 1 1 2 2 2 1 G-protein alpha subunit Ras PF00071.20 001301290.1_21027001_3 - 7e-06 25.6 0.0 1e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.21 001301290.1_21027001_3 - 0.00013 21.9 0.0 0.0002 21.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001301290.1_21027001_3 - 0.0055 16.1 0.0 0.021 14.3 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain V1R PF03402.12 001166862.1_21022001_1 - 1.7e-35 122.8 11.9 1.7e-35 122.8 11.9 1.3 2 0 0 2 2 2 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166862.1_21022001_1 - 2.6e-10 39.8 16.0 3e-10 39.6 16.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166862.1_21022001_1 - 0.0039 16.3 11.8 0.0068 15.5 11.8 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Stathmin PF00836.17 001309408.1_21022001_2 - 9.1e-60 200.4 28.5 1.1e-59 200.1 28.5 1.1 1 0 0 1 1 1 1 Stathmin family Ribonuc_2-5A PF06479.10 001309408.1_21022001_2 - 0.27 11.2 7.2 0.44 10.6 7.2 1.2 1 0 0 1 1 1 0 Ribonuclease 2-5A Exonuc_VII_L PF02601.13 001309408.1_21022001_2 - 2.4 7.5 10.5 3.1 7.2 10.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Mitofilin PF09731.7 001309408.1_21022001_2 - 4.9 5.7 22.6 5.7 5.5 22.6 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein WTX PF09422.8 001309408.1_21022001_2 - 6 5.7 13.6 7.6 5.4 13.6 1.0 1 0 0 1 1 1 0 WTX protein DUF3584 PF12128.6 001309408.1_21022001_2 - 6.9 3.9 18.4 9.1 3.5 18.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Ras PF00071.20 001309409.1_21025001_2 - 2.4e-52 176.7 0.0 3.1e-52 176.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001309409.1_21025001_2 - 1e-18 67.6 0.0 1.5e-18 67.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001309409.1_21025001_2 - 3e-07 29.9 0.0 4.6e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family PET117 PF15786.3 001309409.1_21025001_2 - 0.0022 18.1 0.0 0.0034 17.5 0.0 1.2 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial GTP_EFTU PF00009.25 001309409.1_21025001_2 - 0.18 11.2 0.0 0.48 9.8 0.0 1.6 1 1 0 2 2 2 0 Elongation factor Tu GTP binding domain DUF2080 PF09853.7 001309409.1_21025001_3 - 0.046 13.4 0.0 0.076 12.6 0.0 1.3 1 0 0 1 1 1 0 Putative transposon-encoded protein (DUF2080) zf-RING_UBOX PF13445.4 001256902.1_21023001_1 - 2.7e-11 43.1 6.3 2.7e-11 43.1 6.3 3.3 3 1 0 3 3 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 001256902.1_21023001_1 - 3.1e-09 36.4 1.5 3.1e-09 36.4 1.5 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001256902.1_21023001_1 - 5.8e-09 35.6 6.0 5.8e-09 35.6 6.0 2.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001256902.1_21023001_1 - 2.8e-08 33.7 7.3 2.8e-08 33.7 7.3 3.2 3 0 0 3 3 3 1 Ring finger domain zf-B_box PF00643.22 001256902.1_21023001_1 - 5.1e-08 32.8 2.4 5.1e-08 32.8 2.4 3.4 4 0 0 4 4 4 1 B-box zinc finger zf-C3HC4_4 PF15227.4 001256902.1_21023001_1 - 1.6e-07 31.3 5.6 1.6e-07 31.3 5.6 3.1 2 2 1 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 001256902.1_21023001_1 - 8.4e-07 28.6 5.3 8.4e-07 28.6 5.3 2.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001256902.1_21023001_1 - 1.7e-06 27.7 5.0 1.7e-06 27.7 5.0 2.5 2 0 0 2 2 2 1 zinc-RING finger domain U-box PF04564.13 001256902.1_21023001_1 - 0.00029 20.8 0.0 0.0014 18.6 0.0 2.2 1 1 0 1 1 1 1 U-box domain Prok-RING_4 PF14447.4 001256902.1_21023001_1 - 0.049 13.4 16.1 0.065 13.0 9.7 3.4 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.4 001256902.1_21023001_1 - 0.068 12.8 5.9 0.48 10.1 6.1 2.4 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF1244 PF06844.9 001256902.1_21023001_1 - 0.13 12.3 0.3 0.35 10.9 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1244) zf-Nse PF11789.6 001256902.1_21023001_1 - 0.17 11.6 5.0 0.66 9.7 5.0 2.1 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DUF4061 PF13270.4 001256902.1_21023001_1 - 0.21 11.8 4.6 0.14 12.4 1.5 2.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4061) zinc_ribbon_12 PF11331.6 001256902.1_21023001_1 - 0.23 11.1 0.2 0.23 11.1 0.2 3.1 3 0 0 3 3 3 0 Probable zinc-ribbon domain DZR PF12773.5 001256902.1_21023001_1 - 1.6 8.7 6.0 0.4 10.6 1.4 2.3 2 1 0 2 2 2 0 Double zinc ribbon zf-RING_6 PF14835.4 001256902.1_21023001_1 - 1.7 8.4 8.7 0.073 12.8 2.4 2.1 2 1 0 2 2 2 0 zf-RING of BARD1-type protein HEAT_EZ PF13513.4 001205503.1_06529001_2 - 1.3e-27 95.7 11.2 1.7e-12 47.4 0.0 10.1 10 1 1 11 11 10 4 HEAT-like repeat HEAT PF02985.20 001205503.1_06529001_2 - 1.4e-27 93.2 13.1 0.00092 19.1 0.1 10.7 11 0 0 11 11 11 6 HEAT repeat HEAT_2 PF13646.4 001205503.1_06529001_2 - 1.4e-18 66.9 0.0 5.3e-05 23.4 0.0 6.7 5 3 2 7 7 7 5 HEAT repeats Cnd1 PF12717.5 001205503.1_06529001_2 - 5.2e-16 58.9 0.9 0.0028 17.5 0.7 4.3 3 1 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 IBN_N PF03810.17 001205503.1_06529001_2 - 1.3e-15 56.9 0.1 6.5e-15 54.7 0.0 2.4 2 0 0 2 2 2 1 Importin-beta N-terminal domain Arm PF00514.21 001205503.1_06529001_2 - 1.7e-15 56.3 9.7 0.0044 16.9 0.0 7.5 7 0 0 7 7 7 3 Armadillo/beta-catenin-like repeat Vac14_Fab1_bd PF12755.5 001205503.1_06529001_2 - 4.7e-13 49.4 0.6 0.0031 17.9 0.5 6.2 5 2 3 8 8 7 4 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.18 001205503.1_06529001_2 - 1.7e-08 33.3 7.4 0.0014 17.2 0.2 4.7 3 2 0 3 3 3 2 Adaptin N terminal region UNC45-central PF11701.6 001205503.1_06529001_2 - 9.4e-05 22.3 2.8 0.00076 19.3 0.4 3.2 4 0 0 4 4 4 1 Myosin-binding striated muscle assembly central CLASP_N PF12348.6 001205503.1_06529001_2 - 0.00083 18.9 0.6 2.5 7.5 0.0 4.4 4 2 1 5 5 5 1 CLASP N terminal Dopey_N PF04118.12 001205503.1_06529001_2 - 0.0017 17.4 0.5 0.0058 15.7 0.1 2.0 2 1 0 2 2 2 1 Dopey, N-terminal DUF3385 PF11865.6 001205503.1_06529001_2 - 0.0084 15.9 0.2 12 5.6 0.0 4.4 6 1 1 7 7 7 0 Domain of unknown function (DUF3385) MMS19_C PF12460.6 001205503.1_06529001_2 - 0.0088 15.1 6.9 0.92 8.4 0.1 4.4 5 1 1 6 6 6 2 RNAPII transcription regulator C-terminal TIP120 PF08623.8 001205503.1_06529001_2 - 0.027 14.1 0.2 1.3 8.7 0.4 3.0 4 0 0 4 4 4 0 TATA-binding protein interacting (TIP20) DUF3437 PF11919.6 001205503.1_06529001_2 - 0.066 13.1 0.0 0.99 9.3 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) Xpo1 PF08389.10 001205503.1_06529001_2 - 0.083 12.8 1.0 5.9 6.8 0.0 4.1 3 1 1 4 4 4 0 Exportin 1-like protein DUF2573 PF10835.6 001205503.1_06529001_2 - 0.13 12.5 0.0 0.43 10.8 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2573) CHGN PF05679.14 001205653.1_06529001_1 - 3.9e-81 273.3 0.1 5.3e-81 272.9 0.1 1.1 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Glyco_transf_7C PF02709.12 001205653.1_06529001_1 - 2.3e-08 33.4 0.3 5.9e-08 32.1 0.3 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase KfrA_N PF11740.6 001205653.1_06529001_1 - 0.0064 17.0 0.8 0.0098 16.4 0.8 1.2 1 0 0 1 1 1 1 Plasmid replication region DNA-binding N-term OmpH PF03938.12 001205653.1_06529001_1 - 4 7.3 8.4 8.1 6.3 8.4 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) dsrm PF00035.24 001075678.2_06523001_2 - 1.2e-33 115.5 1.5 1.9e-15 57.2 0.0 3.3 3 0 0 3 3 3 2 Double-stranded RNA binding motif DND1_DSRM PF14709.5 001075678.2_06523001_2 - 7.8e-11 41.9 5.6 8.8e-06 25.8 0.1 4.0 3 2 0 3 3 3 2 double strand RNA binding domain from DEAD END PROTEIN 1 Staufen_C PF16482.3 001075678.2_06523001_2 - 8e-07 29.1 0.1 8.2e-06 25.8 0.0 2.2 2 0 0 2 2 2 1 Staufen C-terminal domain Ras PF00071.20 001301209.1_21027001_2 - 4.1e-54 182.4 0.0 5.6e-54 182.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001301209.1_21027001_2 - 4.7e-19 68.7 0.0 6.9e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001301209.1_21027001_2 - 1.1e-07 31.3 0.0 2e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 001301209.1_21027001_2 - 6.6e-05 22.7 0.5 0.049 13.4 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001301209.1_21027001_2 - 0.0012 18.3 0.0 0.0046 16.4 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001301209.1_21027001_2 - 0.0037 17.2 0.0 0.0055 16.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase T2SSK PF03934.11 001301209.1_21027001_3 - 0.13 11.5 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein K 7tm_1 PF00001.19 001308940.1_21024001_2 - 4.5e-28 98.1 18.9 8.5e-28 97.2 18.9 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR19-TM PF15176.4 001308940.1_21024001_2 - 0.1 12.4 2.9 0.28 11.0 0.1 2.3 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain DUF4044 PF13253.4 001308940.1_21024001_2 - 0.48 9.8 5.2 1.1 8.7 5.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4044) 7tm_1 PF00001.19 001257079.1_21024001_1 - 2.5e-79 266.2 2.7 3.3e-79 265.8 2.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001257079.1_21024001_1 - 2.1e-08 33.8 10.7 1.2e-07 31.3 1.5 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001257079.1_21024001_1 - 6.9e-07 28.7 4.1 6.9e-07 28.7 4.1 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001257079.1_21024001_1 - 2.9e-05 23.8 1.5 2.9e-05 23.8 1.5 2.5 3 0 0 3 3 3 2 Olfactory receptor 7TM_GPCR_Srbc PF10316.7 001257079.1_21024001_1 - 0.0022 17.4 7.2 0.0022 17.4 7.2 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc DUF2417 PF10329.7 001257079.1_21024001_1 - 2.2 7.5 9.3 6.4 6.0 6.8 2.5 2 1 0 2 2 2 0 Region of unknown function (DUF2417) DUF563 PF04577.12 001301185.1_21029001_3 - 2.5e-27 96.3 0.7 3.6e-27 95.7 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Filament PF00038.19 001346193.1_21024001_3 - 2.1e-120 401.9 24.9 2.5e-120 401.6 24.9 1.0 1 0 0 1 1 1 1 Intermediate filament protein Myosin_tail_1 PF01576.17 001346193.1_21024001_3 - 0.007 14.1 27.2 0.022 12.5 9.8 2.2 1 1 1 2 2 2 1 Myosin tail FlxA PF14282.4 001346193.1_21024001_3 - 0.07 13.0 11.2 2.8 7.8 7.7 2.9 2 0 0 2 2 2 0 FlxA-like protein Fib_alpha PF08702.8 001346193.1_21024001_3 - 0.092 12.8 14.0 2.9 8.0 4.9 4.1 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family Bacillus_HBL PF05791.9 001346193.1_21024001_3 - 0.11 12.1 6.7 0.042 13.4 1.5 2.8 1 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF1664 PF07889.10 001346193.1_21024001_3 - 0.23 11.3 15.3 0.54 10.1 1.1 4.3 4 1 0 4 4 4 0 Protein of unknown function (DUF1664) DUF4407 PF14362.4 001346193.1_21024001_3 - 0.25 10.5 14.9 2 7.6 6.1 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) ADIP PF11559.6 001346193.1_21024001_3 - 0.69 9.9 25.6 0.85 9.6 0.7 4.2 3 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding RasGAP_C PF03836.13 001346193.1_21024001_3 - 1 9.4 15.9 0.87 9.6 0.6 3.6 2 1 2 4 4 4 0 RasGAP C-terminus Lectin_N PF03954.12 001346193.1_21024001_3 - 2.6 7.6 7.2 7.5 6.2 0.0 2.9 3 0 0 3 3 3 0 Hepatic lectin, N-terminal domain DUF3373 PF11853.6 001346193.1_21024001_3 - 4.3 5.8 8.1 17 3.9 8.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3373) DUF4446 PF14584.4 001346193.1_21024001_3 - 5 6.9 13.9 3.5 7.5 0.1 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF4446) TPR_MLP1_2 PF07926.10 001346193.1_21024001_3 - 7.7 6.5 29.2 0.076 12.9 0.8 4.2 3 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein DUF16 PF01519.14 001346193.1_21024001_3 - 8.3 6.8 14.1 23 5.4 1.3 4.2 3 1 1 4 4 4 0 Protein of unknown function DUF16 Spc7 PF08317.9 001346193.1_21024001_3 - 9.2 4.9 26.9 1.1 7.9 5.0 3.2 1 1 3 4 4 4 0 Spc7 kinetochore protein BAH PF01426.16 001206282.2_06529001_1 - 1.4e-13 50.7 0.0 2.6e-13 49.7 0.0 1.4 1 1 0 1 1 1 1 BAH domain PI3_PI4_kinase PF00454.25 001309203.1_21029001_2 - 5.5e-52 176.9 0.1 1.7e-51 175.3 0.1 1.9 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.21 001309203.1_21029001_2 - 5.8e-43 147.3 13.5 1.2e-42 146.2 13.5 1.6 1 0 0 1 1 1 1 FAT domain TAN PF11640.6 001309203.1_21029001_2 - 2.7e-23 82.7 1.9 2.7e-23 82.7 1.9 4.0 5 0 0 5 5 5 1 Telomere-length maintenance and DNA damage repair FATC PF02260.18 001309203.1_21029001_2 - 2e-12 46.6 0.0 5.4e-12 45.2 0.0 1.8 1 0 0 1 1 1 1 FATC domain HEAT PF02985.20 001309203.1_21029001_2 - 0.0092 16.0 0.7 29 5.1 0.0 4.5 3 0 0 3 3 3 1 HEAT repeat BTB_2 PF02214.20 001205725.1_06525001_1 - 3.4e-16 59.3 0.1 2.2e-15 56.6 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain LRR_8 PF13855.4 001256918.1_21024001_1 - 2.8e-23 81.3 14.1 2.4e-14 52.7 4.6 4.4 2 1 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 001256918.1_21024001_1 - 5.3e-15 55.1 13.3 2.1e-06 27.8 0.3 4.5 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001256918.1_21024001_1 - 7.4e-07 29.0 0.4 1.5e-06 28.0 0.4 1.5 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) Ig_3 PF13927.4 001256918.1_21024001_1 - 2.9e-06 27.7 0.0 7.1e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001256918.1_21024001_1 - 3.3e-06 27.0 0.0 9e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.31 001256918.1_21024001_1 - 5.5e-05 22.9 11.6 4 8.1 0.0 7.3 7 0 0 7 7 7 2 Leucine Rich Repeat LRR_9 PF14580.4 001256918.1_21024001_1 - 7.8e-05 22.1 1.7 0.00036 19.9 1.0 2.0 1 1 1 2 2 2 1 Leucine-rich repeat Ig_2 PF13895.4 001256918.1_21024001_1 - 0.0008 19.6 0.0 0.0027 17.9 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain LRR_6 PF13516.4 001256918.1_21024001_1 - 0.0014 18.4 11.3 1.1 9.4 0.2 5.3 5 0 0 5 5 5 2 Leucine Rich repeat I-set PF07679.14 001256918.1_21024001_1 - 0.0016 18.3 0.0 0.0029 17.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain LRRNT PF01462.16 001256918.1_21024001_1 - 0.0078 15.7 2.6 0.0078 15.7 2.6 4.1 5 0 0 5 5 5 1 Leucine rich repeat N-terminal domain V-set PF07686.15 001256918.1_21024001_1 - 0.012 15.6 0.0 0.25 11.4 0.0 2.6 1 1 0 1 1 1 0 Immunoglobulin V-set domain Brix PF04427.16 001309177.1_21023001_1 - 1.5e-26 93.6 0.3 2.2e-26 93.0 0.3 1.3 1 0 0 1 1 1 1 Brix domain Peptidase_S30 PF01577.14 001309177.1_21023001_1 - 0.04 13.4 0.3 0.064 12.7 0.3 1.3 1 0 0 1 1 1 0 Potyvirus P1 protease 7tm_1 PF00001.19 001205060.1_21024001_1 - 4.4e-18 65.3 12.9 7.1e-18 64.7 12.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF5136 PF17199.2 001205060.1_21024001_1 - 0.14 11.6 1.2 0.47 10.0 1.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF5136) ETS_PEA3_N PF04621.11 001192834.1_06529001_1 - 3.7e-159 530.1 19.8 4.9e-159 529.6 19.8 1.2 1 0 0 1 1 1 1 PEA3 subfamily ETS-domain transcription factor N terminal domain Ets PF00178.20 001192834.1_06529001_1 - 2.1e-37 127.3 0.2 3.4e-37 126.6 0.2 1.3 1 0 0 1 1 1 1 Ets-domain RRM_3 PF08777.9 001309185.1_21024001_2 - 4.9e-33 113.1 1.7 4.9e-33 113.1 1.7 3.7 3 1 0 3 3 3 1 RNA binding motif La PF05383.15 001309185.1_21024001_2 - 4.2e-22 77.8 0.1 9.2e-22 76.7 0.1 1.6 1 0 0 1 1 1 1 La domain RRM_1 PF00076.20 001309185.1_21024001_2 - 5.9e-15 54.7 0.3 2.6e-10 39.8 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HMA PF00403.24 001309185.1_21024001_2 - 0.15 12.4 1.8 13 6.2 0.0 2.7 2 0 0 2 2 2 0 Heavy-metal-associated domain RRM_1 PF00076.20 001257185.1_21023001_3 - 7.9e-78 256.1 0.8 2.2e-22 78.5 0.1 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 001257185.1_21023001_3 - 9.4e-12 44.5 0.0 0.00012 21.5 0.0 3.3 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001257185.1_21023001_3 - 6.8e-08 32.1 0.0 0.00051 19.7 0.0 3.2 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_3 PF08777.9 001257185.1_21023001_3 - 1e-05 25.3 1.0 0.01 15.7 0.2 2.8 3 0 0 3 3 3 2 RNA binding motif RRM_7 PF16367.3 001257185.1_21023001_3 - 0.00012 22.0 0.4 7.2 6.7 0.1 4.7 4 2 0 4 4 4 1 RNA recognition motif Nup35_RRM_2 PF14605.4 001257185.1_21023001_3 - 0.001 18.8 1.3 15 5.5 0.0 4.0 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif TC1 PF15063.4 001257185.1_21023001_3 - 0.013 15.2 0.1 0.073 12.8 0.0 2.2 2 0 0 2 2 2 0 Thyroid cancer protein 1 DUF4523 PF15023.4 001257185.1_21023001_3 - 0.04 13.6 0.0 2 8.1 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4523) ATP-grasp_2 PF08442.8 001257185.1_21023001_3 - 0.058 12.8 0.1 2.1 7.7 0.0 2.1 2 0 0 2 2 2 0 ATP-grasp domain MHC_I_3 PF16497.3 001252300.1_21023001_1 - 2.3e-79 265.4 2.5 3.3e-79 264.9 2.5 1.2 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001252300.1_21023001_1 - 1.8e-12 47.4 0.0 6e-12 45.7 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001252300.1_21023001_1 - 2e-05 24.1 0.3 2.8e-05 23.6 0.0 1.5 2 0 0 2 2 2 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Ig_3 PF13927.4 001252300.1_21023001_1 - 0.055 14.0 0.0 0.13 12.7 0.0 1.6 1 1 0 1 1 1 0 Immunoglobulin domain Cation_ATPase_C PF00689.19 001163966.1_21029001_1 - 4.1e-44 150.3 2.9 4.1e-44 150.3 2.9 2.2 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.18 001163966.1_21029001_1 - 2.7e-38 131.4 7.8 6.2e-26 90.9 1.4 2.5 2 0 0 2 2 2 2 E1-E2 ATPase ATP_Ca_trans_C PF12424.6 001163966.1_21029001_1 - 4.1e-26 91.1 0.1 1e-25 89.8 0.1 1.7 1 0 0 1 1 1 1 Plasma membrane calcium transporter ATPase C terminal Cation_ATPase PF13246.4 001163966.1_21029001_1 - 8.8e-18 64.1 0.0 1.8e-17 63.1 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 001163966.1_21029001_1 - 4.9e-14 53.0 0.1 5e-13 49.7 0.1 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 001163966.1_21029001_1 - 1.7e-13 49.9 0.0 4.2e-13 48.6 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 001163966.1_21029001_1 - 5.1e-06 26.3 1.9 9.1e-05 22.2 0.4 2.3 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF106 PF01956.14 001163966.1_21029001_1 - 0.096 12.3 0.1 0.27 10.8 0.1 1.7 1 0 0 1 1 1 0 Integral membrane protein DUF106 DAP3 PF10236.7 001309317.1_21024001_2 - 1.8e-92 309.7 0.0 2.2e-92 309.4 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_25 PF13481.4 001309317.1_21024001_2 - 0.047 13.1 0.0 0.077 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.16 001309317.1_21024001_2 - 0.089 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DUF1992 PF09350.8 001256935.1_21023001_1 - 1.2e-21 76.5 1.3 5.5e-21 74.4 0.0 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1992) DnaJ PF00226.29 001256935.1_21023001_1 - 9.3e-12 44.8 3.1 1.2e-10 41.2 0.0 3.3 3 0 0 3 3 3 1 DnaJ domain PP2C_C PF07830.11 001256935.1_21023001_1 - 0.035 14.4 0.1 0.32 11.3 0.0 2.6 2 1 1 3 3 3 0 Protein serine/threonine phosphatase 2C, C-terminal domain AAA_13 PF13166.4 001256935.1_21023001_1 - 3.3 6.1 15.9 0.013 14.1 3.2 2.2 1 1 1 2 2 2 0 AAA domain Amelogenin PF02948.13 001081827.2_21022001_1 - 8.6e-70 234.7 50.7 1.2e-69 234.3 50.7 1.2 1 0 0 1 1 1 1 Amelogenin Tyrosinase PF00264.18 001081840.2_21026001_3 - 2.7e-34 119.3 0.1 4.6e-34 118.5 0.1 1.4 1 0 0 1 1 1 1 Common central domain of tyrosinase Laminin_EGF PF00053.22 001081840.2_21026001_3 - 1.3 9.1 13.7 1.8 8.6 10.7 2.7 2 1 0 2 2 2 0 Laminin EGF domain RRM_1 PF00076.20 001205261.1_21029001_3 - 1.2e-08 34.5 0.0 0.0019 17.9 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 001205261.1_21029001_3 - 4e-05 23.1 0.1 0.025 14.0 0.0 2.4 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2_jaz PF12171.6 001205261.1_21029001_3 - 0.02 15.1 8.7 1.3 9.3 1.1 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding SPRY PF00622.26 001205193.1_21023001_1 - 8.7e-10 38.6 1.1 2e-09 37.5 0.2 2.0 2 0 0 2 2 2 1 SPRY domain zf-RING_UBOX PF13445.4 001205193.1_21023001_1 - 7.7e-09 35.3 1.5 7.7e-09 35.3 1.5 2.2 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001205193.1_21023001_1 - 1e-08 34.8 6.1 2.9e-08 33.3 6.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001205193.1_21023001_1 - 8.6e-08 32.1 6.7 8.6e-08 32.1 6.7 2.1 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.22 001205193.1_21023001_1 - 2.2e-07 30.8 5.5 2.2e-07 30.8 5.5 3.0 2 1 0 2 2 2 1 B-box zinc finger zf-RING_2 PF13639.4 001205193.1_21023001_1 - 1.6e-06 28.1 5.1 1.6e-06 28.1 5.1 2.2 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 001205193.1_21023001_1 - 8.6e-06 25.4 7.8 5.4e-05 22.8 7.8 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001205193.1_21023001_1 - 1e-05 25.2 3.5 1e-05 25.2 3.5 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001205193.1_21023001_1 - 1.6e-05 24.6 5.2 1.6e-05 24.6 5.2 2.1 2 0 0 2 2 1 1 zinc-RING finger domain RE_Alw26IDE PF09665.8 001205193.1_21023001_1 - 0.00085 18.0 2.0 0.25 9.9 0.0 2.2 1 1 1 2 2 2 2 Type II restriction endonuclease (RE_Alw26IDE) Prok-RING_4 PF14447.4 001205193.1_21023001_1 - 0.012 15.3 4.6 0.012 15.3 4.6 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 TMPIT PF07851.11 001205193.1_21023001_1 - 0.03 13.4 6.4 0.049 12.8 6.4 1.5 1 0 0 1 1 1 0 TMPIT-like protein ApoLp-III PF07464.9 001205193.1_21023001_1 - 0.11 12.4 11.8 0.26 11.2 11.8 1.6 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) zf-RING_6 PF14835.4 001205193.1_21023001_1 - 0.13 12.0 7.7 0.59 9.9 7.8 2.0 1 1 0 1 1 1 0 zf-RING of BARD1-type protein zf-C2H2_3 PF13878.4 001205193.1_21023001_1 - 0.29 10.9 1.9 1.4 8.7 0.2 2.7 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO CRT10 PF08728.8 001205193.1_21023001_1 - 0.33 9.0 6.0 0.47 8.5 6.0 1.2 1 0 0 1 1 1 0 CRT10 OmpH PF03938.12 001205193.1_21023001_1 - 0.44 10.4 18.2 0.71 9.7 18.2 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) zf-rbx1 PF12678.5 001205193.1_21023001_1 - 1.2 9.3 7.7 0.12 12.5 2.1 2.3 2 0 0 2 2 2 0 RING-H2 zinc finger domain APG6 PF04111.10 001205193.1_21023001_1 - 1.4 8.1 17.7 2.6 7.2 17.7 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF2951 PF11166.6 001205193.1_21023001_1 - 1.6 8.9 7.8 3.9 7.6 1.9 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) DUF4407 PF14362.4 001205193.1_21023001_1 - 1.9 7.6 10.5 2.7 7.1 10.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-RING_10 PF16685.3 001205193.1_21023001_1 - 3.6 7.7 11.7 0.06 13.3 2.2 2.5 2 0 0 2 2 2 0 zinc RING finger of MSL2 Exonuc_VII_L PF02601.13 001205193.1_21023001_1 - 4.4 6.7 12.3 6.1 6.2 12.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit LMBR1 PF04791.14 001205193.1_21023001_1 - 4.5 5.9 7.6 5.9 5.5 7.6 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein zf-C4 PF00105.16 001081795.2_21027001_1 - 5.6e-32 109.9 12.0 1.1e-31 109.0 12.0 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001081795.2_21027001_1 - 4.2e-31 108.0 6.6 6e-31 107.5 6.6 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Ldh_1_C PF02866.16 001195526.1_21023001_3 - 4.3e-56 189.3 0.0 8.4e-56 188.3 0.0 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.21 001195526.1_21023001_3 - 1.6e-48 164.3 0.0 2.2e-48 163.8 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.22 001195526.1_21023001_3 - 0.0011 19.2 0.0 0.0039 17.5 0.0 1.8 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.17 001195526.1_21023001_3 - 0.0037 16.2 0.0 0.0052 15.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.4 001195526.1_21023001_3 - 0.0081 16.0 0.0 0.032 14.0 0.0 1.8 2 0 0 2 2 2 1 NAD(P)H-binding THF_DHG_CYH_C PF02882.17 001195526.1_21023001_3 - 0.011 15.0 0.0 0.052 12.7 0.0 2.0 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DapB_N PF01113.18 001195526.1_21023001_3 - 0.11 12.5 0.0 0.3 11.1 0.0 1.7 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Carb_anhydrase PF00194.19 001143949.3_21023001_3 - 3e-90 302.1 0.7 3.7e-90 301.8 0.7 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase zf-C3HC4_4 PF15227.4 001205192.1_21024001_1 - 6.2e-13 48.6 9.1 6.2e-13 48.6 9.1 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 001205192.1_21024001_1 - 5.1e-12 45.5 5.6 1.2e-11 44.3 3.0 2.7 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001205192.1_21024001_1 - 5.8e-10 38.7 8.1 1.4e-09 37.5 8.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SPRY PF00622.26 001205192.1_21024001_1 - 6.2e-10 39.1 0.2 1.3e-09 38.1 0.2 1.5 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.22 001205192.1_21024001_1 - 4.3e-09 36.2 4.5 4.3e-09 36.2 4.5 3.5 4 1 0 4 4 3 1 B-box zinc finger zf-C3HC4_2 PF13923.4 001205192.1_21024001_1 - 4.9e-09 35.8 7.5 6.5e-08 32.2 8.1 2.6 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001205192.1_21024001_1 - 1.9e-07 31.1 7.6 1.9e-07 31.1 7.6 2.2 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.4 001205192.1_21024001_1 - 2e-07 30.6 5.3 2e-07 30.6 5.3 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) PRY PF13765.4 001205192.1_21024001_1 - 5.3e-06 25.8 0.0 1.3e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 SPRY-associated domain zf-RING_5 PF14634.4 001205192.1_21024001_1 - 8.8e-06 25.5 6.4 8.8e-06 25.5 6.4 2.0 2 0 0 2 2 1 1 zinc-RING finger domain FAM76 PF16046.3 001205192.1_21024001_1 - 0.00023 20.5 12.8 0.00047 19.5 12.8 1.4 1 0 0 1 1 1 1 FAM76 protein zf-Nse PF11789.6 001205192.1_21024001_1 - 0.0024 17.5 4.2 0.0063 16.2 4.2 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_10 PF16685.3 001205192.1_21024001_1 - 0.0053 16.7 3.1 0.0053 16.7 3.1 2.5 2 0 0 2 2 2 1 zinc RING finger of MSL2 U-box PF04564.13 001205192.1_21024001_1 - 0.0066 16.5 0.0 0.014 15.4 0.0 1.6 1 0 0 1 1 1 1 U-box domain Baculo_IE-1 PF05290.9 001205192.1_21024001_1 - 0.009 15.8 0.4 0.037 13.8 0.4 2.1 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-RING_4 PF14570.4 001205192.1_21024001_1 - 0.011 15.3 5.5 0.011 15.3 5.5 2.6 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain GEP5 PF17053.3 001205192.1_21024001_1 - 0.02 14.6 6.2 0.031 14.0 6.2 1.2 1 0 0 1 1 1 0 Genetic interactor of prohibitin 5 Fib_alpha PF08702.8 001205192.1_21024001_1 - 0.044 13.8 10.5 0.077 13.0 10.5 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Annexin PF00191.18 001205192.1_21024001_1 - 0.14 12.1 1.1 2.1 8.4 0.4 2.8 2 1 0 2 2 2 0 Annexin Phg_2220_C PF09524.8 001205192.1_21024001_1 - 0.17 11.9 0.7 0.4 10.7 0.7 1.6 1 0 0 1 1 1 0 Conserved phage C-terminus (Phg_2220_C) zf-RING_6 PF14835.4 001205192.1_21024001_1 - 0.23 11.2 5.8 0.99 9.2 5.8 2.0 1 1 0 1 1 1 0 zf-RING of BARD1-type protein DiS_P_DiS PF06750.11 001205192.1_21024001_1 - 0.24 11.4 3.1 0.19 11.7 0.9 1.9 2 0 0 2 2 1 0 Bacterial Peptidase A24 N-terminal domain DZR PF12773.5 001205192.1_21024001_1 - 1.4 8.8 12.8 0.068 13.1 5.3 2.5 2 1 0 2 2 2 0 Double zinc ribbon ApoLp-III PF07464.9 001205192.1_21024001_1 - 1.4 8.8 13.6 0.86 9.5 5.6 2.2 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) DUF342 PF03961.11 001205192.1_21024001_1 - 1.5 7.2 7.5 2.4 6.5 7.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Exonuc_VII_L PF02601.13 001205192.1_21024001_1 - 1.6 8.1 7.9 2.2 7.6 7.9 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Prok-RING_4 PF14447.4 001205192.1_21024001_1 - 2.6 7.8 18.0 0.21 11.4 11.2 2.7 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 DUF4407 PF14362.4 001205192.1_21024001_1 - 4.5 6.4 8.5 6.5 5.9 8.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-C3HC4_5 PF17121.3 001205192.1_21024001_1 - 4.7 7.0 9.3 89 3.0 0.4 2.8 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Rad50_zn_hook PF04423.12 001205192.1_21024001_1 - 7.8 6.3 9.9 0.46 10.2 0.2 3.6 3 1 0 3 3 3 0 Rad50 zinc hook motif TMPIT PF07851.11 001205192.1_21024001_1 - 7.9 5.5 10.8 14 4.7 10.8 1.4 1 0 0 1 1 1 0 TMPIT-like protein TIR PF01582.18 001081794.2_21027001_2 - 1.9e-29 102.6 0.0 3.3e-29 101.8 0.0 1.3 1 0 0 1 1 1 1 TIR domain Ig_3 PF13927.4 001081794.2_21027001_2 - 6.1e-20 71.5 0.4 3.6e-05 24.1 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 001081794.2_21027001_2 - 1.6e-17 63.5 3.0 1.1e-10 41.6 0.0 4.0 4 0 0 4 4 4 2 Immunoglobulin domain I-set PF07679.14 001081794.2_21027001_2 - 6.4e-16 58.1 0.1 0.0004 20.3 0.2 3.5 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.23 001081794.2_21027001_2 - 2.1e-09 37.3 0.4 0.0024 17.9 0.1 3.7 3 0 0 3 3 3 3 Immunoglobulin domain Ig_5 PF16681.3 001081794.2_21027001_2 - 0.00032 20.9 1.6 0.18 12.1 0.1 3.6 3 1 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set PF07686.15 001081794.2_21027001_2 - 0.00056 19.9 3.9 8.7 6.4 0.8 5.1 4 1 0 4 4 4 2 Immunoglobulin V-set domain Ig_J_chain PF15097.4 001284535.1_21021001_1 - 8.1e-74 245.7 7.3 9.8e-74 245.5 7.3 1.0 1 0 0 1 1 1 1 Immunoglobulin J chain RTP1_C1 PF10363.7 001284535.1_21021001_1 - 0.0013 18.8 0.0 0.0018 18.2 0.0 1.2 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 1 Med21 PF11221.6 001242512.1_21022001_2 - 1.6e-26 93.2 1.9 3.2e-26 92.2 1.9 1.5 1 1 0 1 1 1 1 Subunit 21 of Mediator complex TelA PF05816.9 001242512.1_21022001_2 - 0.043 12.7 0.2 0.067 12.1 0.2 1.2 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) Flp1_like PF16982.3 001242512.1_21022001_3 - 0.011 14.9 0.8 0.028 13.7 0.8 1.6 1 0 0 1 1 1 0 Putative Flagellin, Flp1-like, domain HEAT_2 PF13646.4 001257084.1_21027001_3 - 4.1e-19 68.6 1.9 1.2e-08 35.1 0.0 6.6 5 2 1 6 6 6 2 HEAT repeats HEAT PF02985.20 001257084.1_21027001_3 - 2.1e-17 61.5 12.8 0.00018 21.3 0.0 8.9 10 0 0 10 10 10 3 HEAT repeat HEAT_EZ PF13513.4 001257084.1_21027001_3 - 9.3e-15 54.6 5.4 1.2e-06 28.7 0.0 7.4 9 0 0 9 9 8 2 HEAT-like repeat Vac14_Fab1_bd PF12755.5 001257084.1_21027001_3 - 4e-10 40.0 8.4 0.00032 21.1 0.0 7.9 7 2 2 9 9 9 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.5 001257084.1_21027001_3 - 3e-08 33.7 3.0 0.00028 20.8 0.2 3.9 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 IFRD PF05004.11 001257084.1_21027001_3 - 1.7e-07 30.5 3.7 0.88 8.5 0.1 5.9 4 2 1 6 6 6 3 Interferon-related developmental regulator (IFRD) RIX1 PF08167.10 001257084.1_21027001_3 - 3.1e-06 26.9 0.7 0.062 12.9 0.0 5.5 4 3 1 5 5 5 1 rRNA processing/ribosome biogenesis Arm PF00514.21 001257084.1_21027001_3 - 5.2e-06 26.2 1.1 6.9 6.7 0.0 6.8 7 0 0 7 7 7 1 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.7 001257084.1_21027001_3 - 0.0027 17.7 0.2 0.24 11.4 0.0 4.0 3 1 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 PF11865.6 001257084.1_21027001_3 - 0.0038 17.0 7.6 5.9 6.6 1.1 6.4 7 1 2 9 9 9 1 Domain of unknown function (DUF3385) DUF4042 PF13251.4 001257084.1_21027001_3 - 0.11 12.1 1.3 1.4 8.5 0.0 3.6 3 1 1 4 4 4 0 Domain of unknown function (DUF4042) IBN_N PF03810.17 001257084.1_21027001_3 - 0.12 12.1 4.3 0.53 10.1 0.0 4.0 5 0 0 5 5 5 0 Importin-beta N-terminal domain SOSSC PF15925.3 001253842.2_21022001_3 - 1.4e-21 77.6 0.8 6.1e-21 75.5 0.8 1.9 1 1 0 1 1 1 1 SOSS complex subunit C BAT2_N PF07001.9 001309164.1_21029001_2 - 5.8e-50 170.3 11.7 5.8e-50 170.3 11.7 11.5 12 3 0 12 12 12 1 BAT2 N-terminus DUF766 PF05571.10 001309418.1_21024001_2 - 8.2e-114 380.0 18.6 1e-113 379.7 18.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF766) TIMP PF00965.15 001081870.2_21023001_1 - 6.8e-66 221.4 7.9 8.2e-66 221.1 7.9 1.1 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase tRNA_bind PF01588.18 001309207.1_21024001_2 - 4.5e-30 103.5 0.0 8.6e-30 102.6 0.0 1.5 1 0 0 1 1 1 1 Putative tRNA binding domain NUDE_C PF04880.11 001309207.1_21024001_2 - 0.32 11.3 6.8 0.091 13.1 2.6 1.9 1 1 1 2 2 2 0 NUDE protein, C-terminal conserved region MAP65_ASE1 PF03999.10 001257080.1_21026001_1 - 4.8e-09 35.3 5.1 3e-08 32.7 4.9 2.0 1 1 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) ANF_receptor PF01094.26 001185088.2_21029001_2 - 5.6e-59 199.9 0.1 9.2e-59 199.2 0.1 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.24 001185088.2_21029001_2 - 1.2e-58 197.0 0.1 2.1e-58 196.3 0.1 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 001185088.2_21029001_2 - 3.2e-45 152.9 0.1 5.8e-45 152.0 0.1 1.4 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 001185088.2_21029001_2 - 6.4e-24 84.5 0.0 1.1e-23 83.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 MHC_I_3 PF16497.3 001252298.1_21023001_1 - 1.6e-86 288.7 0.7 2.1e-86 288.4 0.7 1.1 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001252298.1_21023001_1 - 4.4e-11 43.0 0.0 8.4e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001252298.1_21023001_1 - 3.3e-06 26.6 0.1 4.8e-06 26.1 0.1 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 ig PF00047.23 001252298.1_21023001_1 - 0.11 12.5 0.1 1.2 9.2 0.0 2.3 1 1 1 2 2 2 0 Immunoglobulin domain LRR_8 PF13855.4 001081790.2_21027001_3 - 5.9e-84 275.7 78.9 5.3e-10 38.8 0.6 15.2 9 5 6 15 15 15 14 Leucine rich repeat LRR_4 PF12799.5 001081790.2_21027001_3 - 9.7e-48 159.1 55.6 2.1e-05 24.6 0.3 14.7 12 2 3 15 15 15 15 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001081790.2_21027001_3 - 3.4e-17 60.1 65.6 1.9 9.2 0.0 23.0 23 3 1 24 24 24 6 Leucine Rich Repeat LRR_6 PF13516.4 001081790.2_21027001_3 - 1.9e-09 36.7 61.8 0.39 10.8 0.0 18.2 20 0 0 20 20 20 5 Leucine Rich repeat TIR PF01582.18 001081790.2_21027001_3 - 5.3e-07 29.5 0.0 9e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 TIR domain FNIP PF05725.10 001081790.2_21027001_3 - 5.4e-07 29.5 2.3 0.26 11.4 1.5 5.4 2 2 2 4 4 4 3 FNIP Repeat LRR_9 PF14580.4 001081790.2_21027001_3 - 1.3e-06 27.9 14.5 0.088 12.2 0.2 6.9 5 2 1 7 7 7 3 Leucine-rich repeat LRR_5 PF13306.4 001081790.2_21027001_3 - 3.2e-05 23.7 0.2 0.53 10.1 0.0 4.4 4 1 0 4 4 4 1 Leucine rich repeats (6 copies) TIR_2 PF13676.4 001081790.2_21027001_3 - 0.11 12.7 1.6 0.87 9.8 1.5 2.2 1 1 0 1 1 1 0 TIR domain Filament PF00038.19 001346177.1_21024001_3 - 4.7e-93 312.1 19.3 6.7e-93 311.5 19.3 1.2 1 0 0 1 1 1 1 Intermediate filament protein YlqD PF11068.6 001346177.1_21024001_3 - 0.0085 16.3 6.0 0.0085 16.3 6.0 2.4 3 0 0 3 3 3 1 YlqD protein TPR_MLP1_2 PF07926.10 001346177.1_21024001_3 - 0.12 12.3 25.5 0.038 13.9 1.7 4.0 3 2 1 4 4 4 0 TPR/MLP1/MLP2-like protein DivIC PF04977.13 001346177.1_21024001_3 - 0.45 10.2 10.1 2.1 8.0 0.0 4.6 4 1 1 5 5 5 0 Septum formation initiator DUF4268 PF14088.4 001346177.1_21024001_3 - 0.59 9.9 2.8 0.32 10.7 0.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4268) V_ATPase_I PF01496.17 001346177.1_21024001_3 - 1.1 6.9 9.4 0.25 9.1 5.7 1.6 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Bacillus_HBL PF05791.9 001346177.1_21024001_3 - 1.2 8.7 12.5 0.6 9.7 2.8 3.0 3 1 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) AATF-Che1 PF13339.4 001346177.1_21024001_3 - 2.5 8.6 11.2 0.16 12.5 0.6 2.8 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor Methyltransf_15 PF09445.8 001205698.1_06527001_2 - 1.8e-45 154.5 0.0 3.2e-45 153.7 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.4 001205698.1_06527001_2 - 5.3e-08 33.3 0.0 1.1e-07 32.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.16 001205698.1_06527001_2 - 3.1e-07 30.2 0.0 1.3e-06 28.2 0.0 1.9 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_31 PF13847.4 001205698.1_06527001_2 - 9.3e-07 28.6 0.0 1.9e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.14 001205698.1_06527001_2 - 4.2e-06 26.5 0.0 7.7e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_11 PF08241.10 001205698.1_06527001_2 - 0.00013 22.4 0.0 0.00027 21.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.13 001205698.1_06527001_2 - 0.00013 21.5 0.0 0.0003 20.3 0.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical protein 95 PrmA PF06325.11 001205698.1_06527001_2 - 0.0064 15.8 0.1 0.0064 15.8 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.12 001205698.1_06527001_2 - 0.013 14.9 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_18 PF12847.5 001205698.1_06527001_2 - 0.018 14.9 0.0 0.066 13.0 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Rdx PF10262.7 001168387.1_21022001_3 - 8.9e-05 22.5 0.0 0.00013 22.0 0.0 1.3 1 0 0 1 1 1 1 Rdx family DUF2526 PF10735.7 001168387.1_21022001_3 - 0.093 12.8 0.2 0.14 12.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2526) P_proprotein PF01483.18 001168387.1_21022001_3 - 0.15 12.0 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 Proprotein convertase P-domain zf-H2C2_2 PF13465.4 001351946.1_06525001_3 - 4.8e-24 83.5 30.8 2.2e-07 30.9 0.6 6.3 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2 PF00096.24 001351946.1_06525001_3 - 4.1e-21 74.0 29.2 3.2e-05 24.0 0.1 6.4 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001351946.1_06525001_3 - 9.7e-13 47.7 30.5 0.0056 17.3 4.4 6.6 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2HC_2 PF13913.4 001351946.1_06525001_3 - 0.00028 20.6 4.3 0.43 10.4 0.0 4.6 5 0 0 5 5 5 2 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.3 001351946.1_06525001_3 - 0.00043 19.8 15.1 0.79 9.4 2.1 4.1 4 0 0 4 4 4 3 zinc-finger C2H2-type zf-C2H2_8 PF15909.3 001351946.1_06525001_3 - 0.0011 19.1 8.6 0.0036 17.4 1.6 2.7 1 1 1 2 2 2 1 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.3 001351946.1_06525001_3 - 0.0034 17.4 7.8 3.1 7.8 0.1 4.0 1 1 2 4 4 4 2 Aberrant zinc-finger zf-C2H2_jaz PF12171.6 001351946.1_06525001_3 - 0.21 11.8 8.1 4.2 7.7 0.0 4.3 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 001351946.1_06525001_3 - 2.2 8.6 17.2 0.93 9.8 0.1 4.8 5 0 0 5 5 5 0 Zinc-finger of C2H2 type V1R PF03402.12 001166873.1_21022001_1 - 2.4e-30 105.9 14.9 3.2e-30 105.5 14.9 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001166873.1_21022001_1 - 3.6e-09 36.1 12.9 4.6e-09 35.8 12.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001166873.1_21022001_1 - 0.0002 20.4 18.9 0.00026 20.1 18.9 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Pex24p PF06398.9 001166873.1_21022001_1 - 0.094 11.5 7.4 0.15 10.9 7.4 1.3 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Filament PF00038.19 001346219.1_21025001_1 - 2.1e-101 339.5 37.7 2.5e-101 339.2 37.7 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001346219.1_21025001_1 - 2.4e-21 76.5 31.2 2e-18 66.9 4.6 3.2 2 1 1 3 3 2 2 Keratin type II head CENP-F_leu_zip PF10473.7 001346219.1_21025001_1 - 2.1e-05 24.4 30.3 0.0025 17.7 7.7 3.6 1 1 3 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Alanine_zipper PF11839.6 001346219.1_21025001_1 - 0.0023 18.0 4.4 0.0023 18.0 4.4 2.2 2 0 0 2 2 2 1 Alanine-zipper, major outer membrane lipoprotein TPR_MLP1_2 PF07926.10 001346219.1_21025001_1 - 0.006 16.5 1.9 0.006 16.5 1.9 3.8 2 2 1 3 3 3 2 TPR/MLP1/MLP2-like protein DUF1732 PF08340.9 001346219.1_21025001_1 - 0.015 15.1 3.3 2.3 8.1 0.2 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1732) Spc7 PF08317.9 001346219.1_21025001_1 - 0.038 12.7 35.9 0.03 13.1 11.0 3.2 1 1 1 3 3 3 0 Spc7 kinetochore protein Reo_sigmaC PF04582.10 001346219.1_21025001_1 - 0.056 12.7 7.9 0.12 11.6 1.2 2.5 1 1 1 3 3 3 0 Reovirus sigma C capsid protein DUF1664 PF07889.10 001346219.1_21025001_1 - 0.099 12.5 20.1 0.19 11.6 2.0 4.4 1 1 5 6 6 6 0 Protein of unknown function (DUF1664) DUF5082 PF16888.3 001346219.1_21025001_1 - 0.28 11.4 23.6 0.16 12.2 4.2 4.0 1 1 4 6 6 6 0 Domain of unknown function (DUF5082) IncA PF04156.12 001346219.1_21025001_1 - 0.32 10.6 33.8 2.8 7.5 17.0 3.2 1 1 1 2 2 2 0 IncA protein ArgK PF03308.14 001346219.1_21025001_1 - 0.35 9.7 1.4 0.59 8.9 0.3 1.8 2 0 0 2 2 2 0 ArgK protein DUF948 PF06103.9 001346219.1_21025001_1 - 0.39 10.9 2.9 2.3 8.4 1.9 2.7 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) Baculo_PEP_C PF04513.10 001346219.1_21025001_1 - 0.5 10.3 17.6 0.11 12.4 3.8 3.5 1 1 4 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus JIP_LZII PF16471.3 001346219.1_21025001_1 - 0.68 10.0 19.0 12 6.0 0.6 5.1 3 1 2 5 5 5 0 JNK-interacting protein leucine zipper II NPV_P10 PF05531.10 001346219.1_21025001_1 - 0.75 10.2 14.2 0.25 11.7 1.2 4.1 3 2 1 4 4 4 0 Nucleopolyhedrovirus P10 protein Ribosomal_S30AE PF02482.17 001346219.1_21025001_1 - 0.94 10.2 4.8 0.38 11.4 1.4 2.1 2 0 0 2 2 1 0 Sigma 54 modulation protein / S30EA ribosomal protein DUF4407 PF14362.4 001346219.1_21025001_1 - 1.2 8.3 20.7 89 2.1 19.2 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Jnk-SapK_ap_N PF09744.7 001346219.1_21025001_1 - 2 8.5 29.0 0.12 12.5 1.9 3.4 2 1 0 3 3 3 0 JNK_SAPK-associated protein-1 DUF883 PF05957.11 001346219.1_21025001_1 - 2.9 8.4 16.1 1 9.8 5.8 3.7 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF883) AAA_13 PF13166.4 001346219.1_21025001_1 - 3.1 6.2 25.8 0.66 8.4 20.5 2.1 1 1 1 2 2 2 0 AAA domain ACCA PF03255.12 001346219.1_21025001_1 - 4.2 7.1 14.5 4.9 6.9 0.2 3.5 2 1 1 3 3 3 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit V_ATPase_I PF01496.17 001346219.1_21025001_1 - 4.6 4.9 19.3 0.13 10.0 4.5 2.2 1 1 0 2 2 2 0 V-type ATPase 116kDa subunit family TMPIT PF07851.11 001346219.1_21025001_1 - 6.5 5.8 17.3 0.2 10.7 3.7 2.6 1 1 2 3 3 3 0 TMPIT-like protein Laminin_II PF06009.10 001346219.1_21025001_1 - 7.7 6.4 20.6 2 8.3 1.9 3.3 1 1 4 5 5 5 0 Laminin Domain II DUF4337 PF14235.4 001346219.1_21025001_1 - 8.6 6.3 14.4 0.11 12.5 4.1 2.5 2 2 0 2 2 2 0 Domain of unknown function (DUF4337) ATG16 PF08614.9 001346219.1_21025001_1 - 8.9 6.3 32.8 0.46 10.5 13.8 3.8 1 1 2 4 4 4 0 Autophagy protein 16 (ATG16) Kelch_6 PF13964.4 001257170.1_21025001_1 - 1.7e-22 78.8 4.1 5.9e-07 29.4 0.0 6.5 4 2 2 6 6 6 4 Kelch motif Kelch_1 PF01344.23 001257170.1_21025001_1 - 1.7e-19 69.0 5.6 4.3e-08 32.5 0.0 5.5 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.4 001257170.1_21025001_1 - 2e-05 24.3 3.0 0.03 14.1 0.0 3.7 1 1 2 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.4 001257170.1_21025001_1 - 0.0012 18.9 0.1 0.22 11.7 0.0 3.8 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.13 001257170.1_21025001_1 - 0.0019 18.0 0.5 11 6.0 0.0 4.1 4 0 0 4 4 4 2 Kelch motif PQQ_3 PF13570.4 001257170.1_21025001_1 - 0.083 13.3 2.4 5.1 7.6 0.0 4.5 5 1 0 5 5 5 0 PQQ-like domain Glyco_hydro_18 PF00704.26 001143797.1_21024001_1 - 5.8e-102 341.5 0.0 6.9e-102 341.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_14 PF01607.22 001143797.1_21024001_1 - 2.5e-10 40.3 5.6 4.6e-10 39.4 5.6 1.5 1 0 0 1 1 1 1 Chitin binding Peritrophin-A domain IRK PF01007.18 001257071.1_21023001_3 - 2.5e-135 450.6 0.0 3e-135 450.3 0.0 1.0 1 0 0 1 1 1 1 Inward rectifier potassium channel EI24 PF07264.9 001257071.1_21023001_3 - 0.046 13.8 4.6 0.075 13.1 4.6 1.3 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) Ion_trans_2 PF07885.14 001257071.1_21023001_3 - 0.087 12.7 3.9 0.19 11.6 3.9 1.7 1 1 0 1 1 1 0 Ion channel Phosphorylase PF00343.18 001145253.2_21026001_2 - 0 1157.5 0.0 0 1157.3 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase Rsa3 PF14615.4 001145253.2_21026001_2 - 0.025 14.0 0.1 2.3 7.7 0.0 2.6 2 0 0 2 2 2 0 Ribosome-assembly protein 3 COX_ARM PF06481.12 001145253.2_21026001_2 - 0.16 11.7 0.4 0.45 10.3 0.1 1.9 2 0 0 2 2 2 0 COX Aromatic Rich Motif Defensin_propep PF00879.16 001166080.1_21021001_1 - 3.1e-23 81.7 1.4 4.2e-23 81.3 1.4 1.2 1 0 0 1 1 1 1 Defensin propeptide CDRN PF05174.10 001166080.1_21021001_2 - 0.057 13.0 0.2 0.31 10.6 0.0 2.0 2 0 0 2 2 2 0 Cysteine-rich D. radiodurans N terminus Peptidase_M17 PF00883.19 001309218.1_21024001_3 - 6.9e-126 419.6 0.0 8.8e-126 419.2 0.0 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.15 001309218.1_21024001_3 - 5.8e-20 71.3 0.8 1.6e-19 69.9 0.0 2.1 3 0 0 3 3 3 1 Cytosol aminopeptidase family, N-terminal domain PAW PF04721.15 001309218.1_21024001_3 - 0.047 13.3 0.0 0.077 12.6 0.0 1.2 1 0 0 1 1 1 0 PNGase C-terminal domain, mannose-binding module PAW BTB PF00651.29 001257127.1_21023001_1 - 9.2e-22 77.2 0.0 1.7e-21 76.4 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 001257127.1_21023001_1 - 8.4e-05 22.7 18.8 0.0022 18.2 4.9 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001257127.1_21023001_1 - 0.00025 21.5 18.6 0.0088 16.7 2.8 3.9 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2HC_2 PF13913.4 001257127.1_21023001_1 - 0.019 14.7 2.0 0.019 14.7 2.0 3.4 3 0 0 3 3 3 0 zinc-finger of a C2HC-type Zn_Tnp_IS1595 PF12760.5 001257127.1_21023001_1 - 0.056 13.3 0.7 0.17 11.8 0.7 1.7 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Zn-ribbon_8 PF09723.8 001257127.1_21023001_1 - 0.086 12.8 0.3 0.086 12.8 0.3 1.8 2 0 0 2 2 2 0 Zinc ribbon domain CpXC PF14353.4 001257127.1_21023001_1 - 0.15 12.0 1.6 2 8.3 0.4 2.3 1 1 1 2 2 2 0 CpXC protein zf-C2H2_jaz PF12171.6 001257127.1_21023001_1 - 0.2 11.9 7.0 1 9.6 0.8 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001257127.1_21023001_1 - 1.3 8.9 13.7 1.5 8.8 1.8 3.6 4 0 0 4 4 4 0 C2H2-type zinc finger Pkinase PF00069.23 001205955.1_06526001_3 - 2e-67 227.2 0.0 2.7e-67 226.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001205955.1_06526001_3 - 3.9e-34 118.0 0.0 5.9e-34 117.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PB1 PF00564.22 001205955.1_06526001_3 - 1.1e-14 53.9 0.0 2.7e-14 52.7 0.0 1.6 1 0 0 1 1 1 1 PB1 domain C1_1 PF00130.20 001205955.1_06526001_3 - 1.8e-14 53.2 9.5 1.8e-14 53.2 9.5 3.0 4 0 0 4 4 4 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.22 001205955.1_06526001_3 - 4.1e-05 24.0 2.1 9.7e-05 22.9 2.1 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 001205955.1_06526001_3 - 7.3e-05 22.1 0.0 0.00012 21.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 001205955.1_06526001_3 - 0.03 13.5 0.0 0.095 11.9 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001205955.1_06526001_3 - 0.066 13.0 0.0 0.16 11.7 0.0 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.4 001205955.1_06526001_3 - 0.087 12.3 0.0 1.4 8.3 0.0 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 SelR PF01641.16 001170424.1_21021001_1 - 9.7e-19 67.5 0.3 1.3e-18 67.0 0.3 1.2 1 0 0 1 1 1 1 SelR domain Zn_ribbon_recom PF13408.4 001170424.1_21021001_1 - 0.031 14.7 0.5 8.3 6.9 0.0 2.4 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf-ribbon_3 PF13248.4 001170424.1_21021001_1 - 0.11 11.9 6.3 3.4 7.1 0.2 3.2 3 0 0 3 3 3 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.10 001170424.1_21021001_1 - 0.19 11.1 1.6 6.6 6.2 0.3 2.4 2 0 0 2 2 2 0 TFIIB zinc-binding zinc_ribbon_2 PF13240.4 001170424.1_21021001_1 - 1.2 8.8 6.7 3.7 7.3 0.1 3.0 3 0 0 3 3 3 0 zinc-ribbon domain MBD PF01429.17 001205418.1_06529001_2 - 5.2e-21 74.0 0.0 1.3e-20 72.7 0.0 1.8 1 0 0 1 1 1 1 Methyl-CpG binding domain Bromodomain PF00439.23 001205418.1_06529001_2 - 5.3e-21 74.3 0.0 1.3e-20 73.1 0.0 1.7 1 0 0 1 1 1 1 Bromodomain PHD PF00628.27 001205418.1_06529001_2 - 1.4e-11 44.0 9.2 3.8e-11 42.6 9.2 1.8 1 0 0 1 1 1 1 PHD-finger WSD PF15613.4 001205418.1_06529001_2 - 1.9e-11 44.2 0.1 3e-07 30.7 0.0 5.8 7 0 0 7 7 7 2 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.15 001205418.1_06529001_2 - 3.4e-09 36.7 0.3 7.2e-09 35.7 0.3 1.6 1 0 0 1 1 1 1 DDT domain WHIM1 PF15612.4 001205418.1_06529001_2 - 0.1 12.0 0.0 0.23 10.9 0.0 1.6 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 V1R PF03402.12 001167528.1_21022001_1 - 2.9e-23 82.7 13.5 3.6e-23 82.4 13.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167528.1_21022001_1 - 1.5e-08 34.0 17.7 2.1e-08 33.5 17.7 1.2 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) T_Ag_DNA_bind PF02217.14 001167528.1_21022001_1 - 0.061 13.8 0.2 0.34 11.4 0.0 2.3 2 0 0 2 2 2 0 Origin of replication binding protein Ectatomin PF06457.9 001167528.1_21022001_2 - 0.81 9.5 3.6 6.4 6.7 0.0 2.4 2 0 0 2 2 2 0 Ectatomin Pkinase PF00069.23 001077848.2_06527001_1 - 2.9e-19 69.3 0.0 6.9e-19 68.1 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001077848.2_06527001_1 - 6.2e-19 68.2 0.0 9.7e-19 67.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ras PF00071.20 001308946.1_21024001_3 - 1.8e-57 193.3 0.0 2.4e-57 192.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001308946.1_21024001_3 - 1.5e-22 80.0 0.0 2.1e-22 79.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001308946.1_21024001_3 - 6.3e-09 35.4 0.0 1.1e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001308946.1_21024001_3 - 0.0033 16.9 0.0 0.0054 16.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain SAM_1 PF00536.28 001256925.1_21029001_1 - 7.8e-07 29.3 0.3 2.6e-06 27.6 0.3 2.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 001256925.1_21029001_1 - 2e-06 27.7 0.1 6.8e-06 26.0 0.1 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 001256925.1_21029001_1 - 0.0059 16.4 0.2 0.023 14.5 0.2 2.1 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Ish1 PF10281.7 001256925.1_21029001_1 - 0.19 12.0 2.7 0.28 11.4 0.9 2.4 2 0 0 2 2 2 0 Putative stress-responsive nuclear envelope protein U3snoRNP10 PF12397.6 001256925.1_21029001_1 - 4.8 7.5 5.3 37 4.6 0.0 4.3 5 0 0 5 5 5 0 U3 small nucleolar RNA-associated protein 10 DEAD PF00270.27 001257083.1_21024001_1 - 1.1e-42 145.6 0.0 3.4e-42 144.0 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001257083.1_21024001_1 - 3.3e-28 98.2 0.0 2.4e-26 92.2 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain KH_1 PF00013.27 001257083.1_21024001_1 - 5.6e-13 48.4 4.4 9.1e-12 44.5 1.9 2.4 2 0 0 2 2 2 1 KH domain MOEP19 PF16005.3 001257083.1_21024001_1 - 6.5e-08 32.4 0.1 1.5e-05 24.8 0.0 2.6 2 0 0 2 2 2 1 KH-like RNA-binding domain KH_2 PF07650.15 001257083.1_21024001_1 - 4.9e-05 22.9 0.4 0.00015 21.3 0.4 1.8 1 0 0 1 1 1 1 KH domain ResIII PF04851.13 001257083.1_21024001_1 - 0.00052 19.9 0.0 0.0027 17.6 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.4 001257083.1_21024001_1 - 0.014 14.6 0.0 0.033 13.4 0.0 1.6 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit KH_4 PF13083.4 001257083.1_21024001_1 - 0.049 13.4 0.3 0.18 11.6 0.0 2.1 2 0 0 2 2 2 0 KH domain KH_5 PF13184.4 001257083.1_21024001_1 - 0.058 13.3 0.6 0.16 11.9 0.6 1.7 1 0 0 1 1 1 0 NusA-like KH domain Neur_chan_LBD PF02931.21 001301236.1_21023001_2 - 2.3e-55 187.2 5.1 3.3e-55 186.7 5.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 001301236.1_21023001_2 - 7.2e-41 140.7 0.0 1.4e-40 139.8 0.0 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Arm PF00514.21 001283072.1_21022001_2 - 6.3e-05 22.7 0.0 0.00013 21.7 0.0 1.6 1 0 0 1 1 1 1 Armadillo/beta-catenin-like repeat HMA PF00403.24 001283072.1_21022001_2 - 0.00073 19.8 0.1 0.0013 19.0 0.1 1.4 1 0 0 1 1 1 1 Heavy-metal-associated domain Filament PF00038.19 001346199.1_21024001_1 - 2.3e-107 359.0 40.9 2.7e-107 358.8 40.9 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_tail PF16210.3 001346199.1_21024001_1 - 3.1e-35 121.3 108.8 6.9e-19 68.3 70.6 4.2 2 2 2 4 4 2 2 Keratin type II cytoskeletal 1 tail Keratin_2_head PF16208.3 001346199.1_21024001_1 - 1.7e-34 119.2 107.5 2.8e-23 82.7 23.2 4.2 2 2 1 3 3 2 2 Keratin type II head TPR_MLP1_2 PF07926.10 001346199.1_21024001_1 - 4.1e-10 39.7 39.4 1.8e-06 27.9 3.9 3.8 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein Alanine_zipper PF11839.6 001346199.1_21024001_1 - 0.0002 21.4 3.1 0.0002 21.4 3.1 3.1 3 1 0 3 3 2 1 Alanine-zipper, major outer membrane lipoprotein Spc7 PF08317.9 001346199.1_21024001_1 - 0.00033 19.5 41.0 0.0026 16.6 16.0 3.0 1 1 2 3 3 3 2 Spc7 kinetochore protein JIP_LZII PF16471.3 001346199.1_21024001_1 - 0.0011 19.0 25.6 0.85 9.7 0.7 5.7 4 1 1 6 6 5 2 JNK-interacting protein leucine zipper II DUF4407 PF14362.4 001346199.1_21024001_1 - 0.0012 18.1 26.4 0.093 11.9 11.6 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF4407) ADIP PF11559.6 001346199.1_21024001_1 - 0.0058 16.6 8.5 0.0058 16.6 8.5 4.1 3 1 1 4 4 4 1 Afadin- and alpha -actinin-Binding IncA PF04156.12 001346199.1_21024001_1 - 0.0085 15.8 44.0 0.21 11.2 15.6 3.5 1 1 0 2 2 2 1 IncA protein Reo_sigmaC PF04582.10 001346199.1_21024001_1 - 0.0092 15.3 16.6 0.58 9.4 2.2 3.1 1 1 2 3 3 3 2 Reovirus sigma C capsid protein Cast PF10174.7 001346199.1_21024001_1 - 0.013 13.7 29.2 0.025 12.7 29.2 1.5 1 1 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone ABC_tran_CTD PF16326.3 001346199.1_21024001_1 - 0.013 15.6 8.0 0.013 15.6 8.0 4.0 4 1 0 4 4 3 0 ABC transporter C-terminal domain AAA_13 PF13166.4 001346199.1_21024001_1 - 0.015 13.9 29.5 0.096 11.2 29.2 2.2 1 1 0 1 1 1 0 AAA domain DUF1664 PF07889.10 001346199.1_21024001_1 - 0.015 15.1 24.2 0.079 12.8 1.7 4.4 2 2 3 5 5 5 0 Protein of unknown function (DUF1664) YlqD PF11068.6 001346199.1_21024001_1 - 0.019 15.2 3.4 0.019 15.2 3.4 4.1 1 1 3 4 4 4 0 YlqD protein SlyX PF04102.10 001346199.1_21024001_1 - 0.029 14.8 2.6 0.029 14.8 2.6 5.5 4 2 2 6 6 6 0 SlyX CENP-F_leu_zip PF10473.7 001346199.1_21024001_1 - 0.033 14.1 34.6 0.19 11.6 6.6 3.6 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 UME PF08064.11 001346199.1_21024001_1 - 0.038 13.8 0.1 0.11 12.3 0.1 1.7 1 0 0 1 1 1 0 UME (NUC010) domain Lebercilin PF15619.4 001346199.1_21024001_1 - 0.056 13.0 35.8 1.4 8.3 0.4 3.3 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease MukF_M PF17192.2 001346199.1_21024001_1 - 0.073 12.7 18.0 0.09 12.4 7.1 2.7 2 1 1 3 3 3 0 MukF middle domain LPP PF04728.11 001346199.1_21024001_1 - 0.077 13.3 0.7 0.077 13.3 0.7 5.1 5 1 0 5 5 4 0 Lipoprotein leucine-zipper She9_MDM33 PF05546.9 001346199.1_21024001_1 - 0.12 12.0 19.4 0.15 11.7 2.1 2.8 1 1 2 3 3 3 0 She9 / Mdm33 family ATG16 PF08614.9 001346199.1_21024001_1 - 0.14 12.2 35.3 2.5 8.1 11.7 3.2 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) FPP PF05911.9 001346199.1_21024001_1 - 0.15 10.1 32.6 0.25 9.4 16.5 2.0 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil Tropomyosin_1 PF12718.5 001346199.1_21024001_1 - 0.17 11.9 36.2 0.023 14.7 12.4 3.6 2 1 2 4 4 4 0 Tropomyosin like Baculo_PEP_C PF04513.10 001346199.1_21024001_1 - 0.17 11.8 25.6 0.04 13.8 6.2 4.4 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4140 PF13600.4 001346199.1_21024001_1 - 0.21 11.9 30.2 0.23 11.8 1.8 5.2 2 2 2 5 5 5 0 N-terminal domain of unknown function (DUF4140) DUF812 PF05667.9 001346199.1_21024001_1 - 0.21 10.3 35.7 0.99 8.1 16.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF812) CHDCT2 PF08074.9 001346199.1_21024001_1 - 0.37 10.8 18.4 3.7 7.5 4.6 3.4 2 2 0 2 2 2 0 CHDCT2 (NUC038) domain XhlA PF10779.7 001346199.1_21024001_1 - 0.39 10.8 17.3 1.9 8.6 0.1 4.4 4 1 0 5 5 3 0 Haemolysin XhlA Golgin_A5 PF09787.7 001346199.1_21024001_1 - 0.56 9.5 40.2 0.14 11.5 12.7 3.4 1 1 3 4 4 4 0 Golgin subfamily A member 5 GARP PF16731.3 001346199.1_21024001_1 - 0.86 9.1 11.8 0.047 13.2 2.9 2.7 3 0 0 3 3 2 0 Glutamic acid/alanine-rich protein of Trypanosoma DUF3502 PF12010.6 001346199.1_21024001_1 - 1.1 9.8 11.5 2.8 8.4 0.5 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF3502) DUF1732 PF08340.9 001346199.1_21024001_1 - 1.4 8.8 9.8 0.19 11.6 0.2 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF1732) Fib_alpha PF08702.8 001346199.1_21024001_1 - 1.6 8.7 38.3 0.18 11.9 8.4 4.1 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family TRAF_BIRC3_bd PF16673.3 001346199.1_21024001_1 - 2.4 7.9 10.5 14 5.4 0.1 3.7 3 0 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain Jnk-SapK_ap_N PF09744.7 001346199.1_21024001_1 - 2.4 8.2 39.1 0.76 9.9 9.6 3.7 1 1 2 4 4 4 0 JNK_SAPK-associated protein-1 ANAPC4 PF12896.5 001346199.1_21024001_1 - 2.6 7.3 12.8 5 6.4 1.2 3.3 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 4 NPV_P10 PF05531.10 001346199.1_21024001_1 - 3.3 8.1 25.1 0.063 13.6 2.1 4.4 2 1 2 4 4 3 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.9 001346199.1_21024001_1 - 3.4 7.9 17.0 0.083 13.0 1.2 3.9 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF948) TSC22 PF01166.16 001346199.1_21024001_1 - 4 7.7 24.2 1.2 9.4 0.4 4.9 4 1 2 6 6 5 0 TSC-22/dip/bun family CLZ PF16526.3 001346199.1_21024001_1 - 4.5 7.6 24.2 1.2 9.4 3.9 5.2 3 2 2 5 5 5 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF1451 PF07295.9 001346199.1_21024001_1 - 4.6 7.2 17.9 0.62 10.0 3.4 3.0 2 1 1 3 3 3 0 Zinc-ribbon containing domain Ax_dynein_light PF10211.7 001346199.1_21024001_1 - 5.3 6.8 33.5 0.23 11.2 7.1 4.1 1 1 3 4 4 4 0 Axonemal dynein light chain GAS PF13851.4 001346199.1_21024001_1 - 6.7 5.9 40.0 0.12 11.6 10.1 4.0 1 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding DUF745 PF05335.11 001346199.1_21024001_1 - 7.4 6.1 26.9 2.3 7.8 12.6 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF745) RPW8 PF05659.9 001346199.1_21024001_1 - 7.4 6.1 18.7 2.1 7.9 2.4 3.7 1 1 2 4 4 4 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 bZIP_2 PF07716.13 001346199.1_21024001_1 - 7.6 6.6 25.3 2.7 8.0 0.9 5.6 5 0 0 5 5 5 0 Basic region leucine zipper Rootletin PF15035.4 001346199.1_21024001_1 - 8 6.4 33.4 11 5.9 18.2 3.1 1 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion ApoLp-III PF07464.9 001346199.1_21024001_1 - 8.1 6.4 25.0 0.91 9.5 7.0 3.1 1 1 2 3 3 3 0 Apolipophorin-III precursor (apoLp-III) GPS2_interact PF15784.3 001346199.1_21024001_1 - 8.3 7.0 14.1 1.6 9.3 3.1 3.1 2 1 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain Tropomyosin PF00261.18 001346199.1_21024001_1 - 8.7 5.5 31.6 3.2 6.9 11.1 3.7 2 2 1 3 3 3 0 Tropomyosin SOGA PF11365.6 001346199.1_21024001_1 - 9 7.4 24.0 1.8 9.6 2.1 4.4 3 1 0 4 4 4 0 Protein SOGA Cnn_1N PF07989.9 001346199.1_21024001_1 - 9.5 6.3 24.3 9.9 6.2 7.0 4.6 2 2 2 4 4 4 0 Centrosomin N-terminal motif 1 GLTT PF01744.18 001346199.1_21024001_2 - 0.77 9.4 17.7 0.063 12.9 6.9 2.8 2 1 1 3 3 3 0 GLTT repeat (6 copies) AAA PF00004.27 001309341.1_21024001_1 - 2.8e-39 134.4 0.0 5.1e-39 133.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.8 001309341.1_21024001_1 - 3.9e-09 36.2 0.1 1.4e-08 34.4 0.0 2.1 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain AAA_2 PF07724.12 001309341.1_21024001_1 - 1.1e-05 25.5 0.0 2.3e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.10 001309341.1_21024001_1 - 3.2e-05 23.2 0.0 7.3e-05 22.0 0.0 1.6 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.4 001309341.1_21024001_1 - 5.2e-05 23.3 1.5 0.0002 21.4 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_5 PF07728.12 001309341.1_21024001_1 - 0.00024 21.0 0.2 0.0016 18.3 0.2 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.15 001309341.1_21024001_1 - 0.00087 19.0 0.0 0.0075 15.9 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein TIP49 PF06068.11 001309341.1_21024001_1 - 0.0012 17.7 0.0 0.0024 16.8 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus Mg_chelatase PF01078.19 001309341.1_21024001_1 - 0.0042 16.4 0.0 0.0084 15.4 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.4 001309341.1_21024001_1 - 0.0042 17.3 0.1 0.011 16.0 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.4 001309341.1_21024001_1 - 0.0051 16.7 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain TsaE PF02367.15 001309341.1_21024001_1 - 0.0075 16.1 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.4 001309341.1_21024001_1 - 0.0091 16.1 1.0 0.11 12.6 0.3 2.8 2 1 1 3 3 3 1 AAA domain ATPase PF06745.11 001309341.1_21024001_1 - 0.022 14.0 0.2 1.3 8.2 0.1 2.4 1 1 1 2 2 2 0 KaiC PhoH PF02562.14 001309341.1_21024001_1 - 0.04 13.2 0.7 0.06 12.7 0.1 1.5 2 0 0 2 2 2 0 PhoH-like protein RNA_helicase PF00910.20 001309341.1_21024001_1 - 0.059 13.6 0.3 0.19 12.0 0.0 2.1 2 0 0 2 2 2 0 RNA helicase ABC_tran PF00005.25 001309341.1_21024001_1 - 0.084 13.3 0.5 0.54 10.6 0.0 2.3 3 0 0 3 3 2 0 ABC transporter TPR_1 PF00515.26 001309341.1_21024001_1 - 0.14 11.9 0.4 0.65 9.8 0.2 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat NACHT PF05729.10 001309341.1_21024001_1 - 0.16 11.7 0.1 0.51 10.1 0.1 1.9 1 1 0 1 1 1 0 NACHT domain AAA_18 PF13238.4 001309341.1_21024001_1 - 0.24 11.8 2.8 0.39 11.1 1.1 2.3 2 1 0 2 2 1 0 AAA domain TPR_8 PF13181.4 001309341.1_21024001_1 - 0.38 11.0 1.9 0.46 10.7 0.1 2.1 2 0 0 2 2 1 0 Tetratricopeptide repeat TPR_2 PF07719.15 001309341.1_21024001_1 - 0.38 10.9 1.7 1.3 9.2 0.3 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Myb_Cef PF11831.6 001301220.1_21029001_1 - 1e-82 277.2 6.2 1e-82 277.2 6.2 2.8 3 0 0 3 3 3 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.29 001301220.1_21029001_1 - 2e-20 72.6 7.2 1.2e-11 44.4 1.9 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.4 001301220.1_21029001_1 - 9.5e-18 64.1 9.1 2.2e-13 50.1 4.7 2.9 2 1 1 3 3 3 2 Myb-like DNA-binding domain Rap1_C PF11626.6 001301220.1_21029001_1 - 0.044 13.7 0.2 0.16 12.0 0.2 1.9 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain PXA PF02194.13 001191536.1_06527001_1 - 9.3e-37 126.3 1.7 3.2e-36 124.6 1.5 2.1 2 0 0 2 2 2 1 PXA domain PX PF00787.22 001191536.1_06527001_1 - 1.8e-20 72.9 1.8 1.8e-20 72.9 1.8 3.1 4 0 0 4 4 4 1 PX domain Nexin_C PF08628.10 001191536.1_06527001_1 - 1.6e-15 57.6 0.0 6e-15 55.7 0.0 2.1 2 0 0 2 2 2 1 Sorting nexin C terminal RGS PF00615.17 001191536.1_06527001_1 - 8.5e-11 42.0 2.0 3e-10 40.3 2.0 2.0 1 0 0 1 1 1 1 Regulator of G protein signaling domain zf-H2C2_2 PF13465.4 001257122.1_21029001_1 - 0.00041 20.5 5.9 0.0014 18.8 0.9 8.4 8 0 0 8 8 8 3 Zinc-finger double domain zf-H2C2_5 PF13909.4 001257122.1_21029001_1 - 0.0048 16.5 0.6 0.0048 16.5 0.6 5.1 5 0 0 5 5 5 1 C2H2-type zinc-finger domain Imm44 PF15571.4 001257122.1_21029001_1 - 0.076 13.1 2.2 0.23 11.6 2.2 1.8 1 0 0 1 1 1 0 Immunity protein 44 zf-C2H2 PF00096.24 001257122.1_21029001_1 - 6.9 7.2 64.3 0.043 14.1 1.4 8.5 9 0 0 9 9 9 0 Zinc finger, C2H2 type Defensin_propep PF00879.16 001166091.1_21021001_1 - 2.2e-22 79.0 3.6 3e-22 78.6 3.6 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166091.1_21021001_2 - 0.0023 18.3 0.3 0.0044 17.4 0.3 1.5 1 0 0 1 1 1 1 Mammalian defensin WHIM1 PF15612.4 001301166.1_21029001_1 - 6.9e-12 44.5 0.3 1.4e-11 43.5 0.3 1.5 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 PHD PF00628.27 001301166.1_21029001_1 - 1.5e-09 37.5 4.3 1.5e-09 37.5 4.3 3.4 2 0 0 2 2 2 1 PHD-finger DDT PF02791.15 001301166.1_21029001_1 - 0.057 13.6 0.0 0.15 12.3 0.0 1.8 1 0 0 1 1 1 0 DDT domain LRR_8 PF13855.4 001257070.1_21026001_1 - 1.3e-58 194.5 55.4 2.6e-16 59.0 3.3 6.5 2 2 5 7 7 7 6 Leucine rich repeat LRR_4 PF12799.5 001257070.1_21026001_1 - 2.4e-19 68.9 43.1 5.3e-06 26.5 0.2 8.4 5 1 1 7 7 7 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001257070.1_21026001_1 - 3.3e-17 62.5 0.0 3.9e-08 33.2 0.1 2.4 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001257070.1_21026001_1 - 5.6e-07 29.1 15.0 0.026 13.9 0.1 4.4 2 2 2 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.31 001257070.1_21026001_1 - 0.00019 21.3 37.8 1.6 9.4 0.2 12.0 13 0 0 13 13 12 2 Leucine Rich Repeat Neur_chan_memb PF02932.14 001257070.1_21026001_1 - 0.0075 16.2 0.3 0.012 15.5 0.3 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region LRRCT PF01463.22 001257070.1_21026001_1 - 0.012 15.9 0.2 3 8.5 0.0 3.2 2 0 0 2 2 2 0 Leucine rich repeat C-terminal domain TPKR_C2 PF16920.3 001257070.1_21026001_1 - 0.028 14.4 0.6 0.028 14.4 0.6 3.1 3 0 0 3 3 3 0 Tyrosine-protein kinase receptor C2 Ig-like domain DUF1049 PF06305.9 001257070.1_21026001_1 - 0.04 13.6 0.2 0.14 11.9 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) TMEM154 PF15102.4 001257070.1_21026001_1 - 0.044 13.6 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 TMEM154 protein family EphA2_TM PF14575.4 001257070.1_21026001_1 - 0.056 14.1 0.0 0.12 13.1 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain IncA PF04156.12 001257070.1_21026001_1 - 0.092 12.4 0.9 0.29 10.8 0.9 1.8 1 1 0 1 1 1 0 IncA protein Trypsin PF00089.24 001081875.3_21023001_2 - 2.9e-67 226.6 0.1 3.5e-67 226.3 0.1 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001081875.3_21023001_2 - 6e-08 33.6 0.0 1e-07 32.8 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001081875.3_21023001_2 - 0.013 15.8 0.1 0.043 14.1 0.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1986) UCH PF00443.27 001301148.1_21029001_3 - 1.3e-50 172.2 0.2 2.5e-49 168.0 0.0 2.7 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 001301148.1_21029001_3 - 4.4e-23 82.2 0.0 5e-22 78.8 0.0 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF1722 PF08349.9 001301148.1_21029001_3 - 0.074 13.2 0.0 13 6.0 0.0 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1722) Utp13 PF08625.9 001301148.1_21029001_3 - 0.78 9.5 3.6 12 5.6 0.6 3.1 1 1 1 2 2 2 0 Utp13 specific WD40 associated domain Filament PF00038.19 001346209.1_21025001_2 - 1.7e-115 385.7 34.7 2e-115 385.5 34.7 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001346209.1_21025001_2 - 5.2e-40 137.1 45.1 5.2e-40 137.1 45.1 2.6 2 1 0 2 2 1 1 Keratin type II head TPR_MLP1_2 PF07926.10 001346209.1_21025001_2 - 9.7e-07 28.8 30.5 0.00011 22.1 1.1 3.7 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein Gp58 PF07902.9 001346209.1_21025001_2 - 0.00055 18.4 9.1 0.00081 17.8 9.1 1.3 1 0 0 1 1 1 1 gp58-like protein Spc7 PF08317.9 001346209.1_21025001_2 - 0.00071 18.4 31.3 0.0014 17.4 5.8 2.9 1 1 1 2 2 2 2 Spc7 kinetochore protein CENP-F_leu_zip PF10473.7 001346209.1_21025001_2 - 0.0013 18.6 22.9 0.01 15.7 5.4 3.1 1 1 1 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.4 001346209.1_21025001_2 - 0.0015 17.1 19.0 0.0019 16.8 18.0 1.6 1 1 0 1 1 1 1 AAA domain Alanine_zipper PF11839.6 001346209.1_21025001_2 - 0.0058 16.7 4.4 0.0058 16.7 4.4 2.2 2 0 0 2 2 2 1 Alanine-zipper, major outer membrane lipoprotein Reo_sigmaC PF04582.10 001346209.1_21025001_2 - 0.006 15.9 6.1 0.14 11.3 0.4 2.5 1 1 0 2 2 2 1 Reovirus sigma C capsid protein Jnk-SapK_ap_N PF09744.7 001346209.1_21025001_2 - 0.011 15.8 3.5 0.011 15.8 3.5 3.4 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 ADIP PF11559.6 001346209.1_21025001_2 - 0.041 13.8 23.5 0.02 14.8 6.2 3.4 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Golgin_A5 PF09787.7 001346209.1_21025001_2 - 0.072 12.4 26.8 0.032 13.6 9.0 2.8 1 1 3 4 4 4 0 Golgin subfamily A member 5 DUF1192 PF06698.9 001346209.1_21025001_2 - 0.079 12.9 3.6 0.61 10.1 0.3 3.2 3 1 0 3 3 2 0 Protein of unknown function (DUF1192) UPF0184 PF03670.11 001346209.1_21025001_2 - 0.081 13.2 2.6 0.24 11.7 0.1 2.8 2 1 1 3 3 2 0 Uncharacterised protein family (UPF0184) IncA PF04156.12 001346209.1_21025001_2 - 0.1 12.3 28.8 0.11 12.1 10.3 3.3 1 1 2 3 3 3 0 IncA protein DUF745 PF05335.11 001346209.1_21025001_2 - 0.11 12.1 17.8 0.99 9.0 10.8 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF745) Virulence_fact PF13769.4 001346209.1_21025001_2 - 0.11 12.5 5.3 3 7.9 0.0 3.3 2 1 1 3 3 3 0 Virulence factor UME PF08064.11 001346209.1_21025001_2 - 0.16 11.8 0.1 0.39 10.5 0.1 1.6 1 0 0 1 1 1 0 UME (NUC010) domain DUF4407 PF14362.4 001346209.1_21025001_2 - 0.18 11.0 21.2 0.37 10.0 1.9 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Baculo_PEP_C PF04513.10 001346209.1_21025001_2 - 0.86 9.5 19.1 0.72 9.8 2.3 3.8 1 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.10 001346209.1_21025001_2 - 0.89 9.4 15.6 1.6 8.6 1.6 4.0 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.8 001346209.1_21025001_2 - 0.91 9.6 25.9 0.1 12.6 2.3 4.0 1 1 2 4 4 4 0 Fibrinogen alpha/beta chain family PRKG1_interact PF15898.3 001346209.1_21025001_2 - 0.94 10.3 20.5 2.5 8.9 0.3 3.7 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain DASH_Duo1 PF08651.8 001346209.1_21025001_2 - 1.1 9.0 9.3 0.97 9.1 0.9 3.8 3 1 0 3 3 3 0 DASH complex subunit Duo1 TMF_TATA_bd PF12325.6 001346209.1_21025001_2 - 1.2 9.2 24.4 2.8 8.1 0.7 3.9 2 2 2 4 4 4 0 TATA element modulatory factor 1 TATA binding APG6 PF04111.10 001346209.1_21025001_2 - 1.3 8.2 31.5 0.063 12.5 5.8 3.0 1 1 2 3 3 3 0 Autophagy protein Apg6 DUF883 PF05957.11 001346209.1_21025001_2 - 1.5 9.3 15.9 2.4 8.7 4.0 3.9 3 1 1 4 4 3 0 Bacterial protein of unknown function (DUF883) GAS PF13851.4 001346209.1_21025001_2 - 1.6 7.9 29.3 0.01 15.1 8.1 3.1 1 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Tropomyosin_1 PF12718.5 001346209.1_21025001_2 - 1.7 8.6 26.3 0.055 13.5 9.3 3.2 2 1 1 3 3 3 0 Tropomyosin like LPP PF04728.11 001346209.1_21025001_2 - 2 8.7 11.0 1.1 9.5 0.3 4.4 4 1 1 5 5 4 0 Lipoprotein leucine-zipper ATPase PF06745.11 001346209.1_21025001_2 - 2.3 7.4 5.0 17 4.6 0.1 2.5 2 1 0 2 2 2 0 KaiC CHDCT2 PF08074.9 001346209.1_21025001_2 - 3.1 7.8 13.3 4.5 7.3 1.2 2.7 1 1 0 2 2 2 0 CHDCT2 (NUC038) domain DUF1451 PF07295.9 001346209.1_21025001_2 - 3.2 7.7 14.4 1.5 8.7 3.8 2.6 2 1 0 2 2 2 0 Zinc-ribbon containing domain DUF5082 PF16888.3 001346209.1_21025001_2 - 4.8 7.4 22.9 9.5 6.5 0.6 4.4 1 1 2 4 4 4 0 Domain of unknown function (DUF5082) RPW8 PF05659.9 001346209.1_21025001_2 - 6.5 6.3 11.0 9.9 5.7 0.3 3.2 2 2 1 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Rootletin PF15035.4 001346209.1_21025001_2 - 7.2 6.5 24.8 5.7 6.8 5.4 2.4 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF948 PF06103.9 001346209.1_21025001_2 - 8 6.7 11.8 5.6 7.2 1.0 4.0 3 2 2 5 5 4 0 Bacterial protein of unknown function (DUF948) BRE1 PF08647.9 001346209.1_21025001_2 - 8.3 6.4 27.6 0.2 11.6 4.8 4.4 1 1 5 6 6 6 0 BRE1 E3 ubiquitin ligase BLOC1_2 PF10046.7 001346209.1_21025001_2 - 8.6 6.6 19.0 1.9 8.7 0.3 4.3 1 1 3 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Bap31 PF05529.10 001346209.1_21025001_2 - 9.4 5.7 21.8 0.032 13.7 3.7 3.2 1 1 2 3 3 3 0 B-cell receptor-associated protein 31-like V_ATPase_I PF01496.17 001346209.1_21025001_2 - 9.6 3.8 21.6 0.061 11.1 4.5 2.5 1 1 2 3 3 3 0 V-type ATPase 116kDa subunit family Uteroglobin PF01099.15 001081858.2_21021001_2 - 1.1e-19 70.3 0.1 1.6e-19 69.8 0.1 1.3 1 0 0 1 1 1 1 Uteroglobin family DNA_ligase_A_M PF01068.19 001256929.1_21026001_2 - 3.5e-56 189.9 0.8 9.5e-56 188.5 0.2 2.1 2 0 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.12 001256929.1_21026001_2 - 1.2e-42 146.0 0.3 2.7e-42 144.9 0.3 1.6 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_IV PF11411.6 001256929.1_21026001_2 - 2e-17 62.8 0.8 2e-17 62.8 0.8 2.2 2 0 0 2 2 2 1 DNA ligase IV DNA_ligase_A_C PF04679.13 001256929.1_21026001_2 - 2.8e-17 63.0 0.0 9.4e-17 61.3 0.0 2.0 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region BRCT PF00533.24 001256929.1_21026001_2 - 4.5e-17 62.1 0.0 7.5e-10 39.0 0.0 3.4 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.3 001256929.1_21026001_2 - 2e-14 53.6 0.1 1e-09 38.6 0.0 2.8 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain RNA_ligase PF09414.8 001256929.1_21026001_2 - 7.3e-10 39.2 0.0 1.6e-09 38.1 0.0 1.6 1 0 0 1 1 1 1 RNA ligase RTT107_BRCT_5 PF16770.3 001256929.1_21026001_2 - 0.033 13.9 0.0 4.3 7.1 0.0 2.9 2 0 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain mRNA_cap_enzyme PF01331.17 001256929.1_21026001_2 - 0.073 12.7 0.7 0.91 9.2 0.7 2.4 1 1 0 1 1 1 0 mRNA capping enzyme, catalytic domain SSPI PF14098.4 001256929.1_21026001_2 - 0.22 11.6 1.1 0.88 9.6 1.1 2.0 1 0 0 1 1 1 0 Small, acid-soluble spore protein I 7tm_1 PF00001.19 001257166.1_21023001_1 - 1e-61 208.4 18.0 1.5e-61 207.8 18.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001257166.1_21023001_1 - 1e-08 34.8 22.7 1.4e-08 34.3 22.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Peptidase_M1 PF01433.18 001309217.2_21029001_2 - 7.9e-15 54.9 0.6 2.1e-14 53.5 0.6 1.6 1 1 0 1 1 1 1 Peptidase family M1 HEAT_2 PF13646.4 001309217.2_21029001_2 - 1.1e-05 25.6 0.0 0.41 10.9 0.0 3.4 4 1 1 5 5 5 3 HEAT repeats HEAT PF02985.20 001309217.2_21029001_2 - 0.004 17.1 1.6 0.87 9.9 0.1 4.7 5 0 0 5 5 5 1 HEAT repeat AP3D1 PF06375.9 001309217.2_21029001_2 - 0.16 12.1 10.0 0.3 11.2 10.0 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 SelP_N PF04592.12 001309217.2_21029001_2 - 1.5 8.0 20.7 2.9 7.1 20.7 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region SR-25 PF10500.7 001309217.2_21029001_2 - 1.7 8.0 16.5 2.7 7.4 16.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MHC_II_alpha PF00993.18 001142814.1_21022001_1 - 5.3e-38 128.4 0.0 7.3e-38 128.0 0.0 1.2 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001142814.1_21022001_1 - 2e-26 91.0 0.1 2e-26 91.0 0.1 1.8 2 0 0 2 2 2 1 C1-set C-terminal domain C1-set PF07654.13 001142814.1_21022001_1 - 6.9e-26 90.4 0.0 1.1e-25 89.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001142814.1_21022001_1 - 2.6e-05 24.6 0.0 5.6e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Marek_A PF02124.13 001142814.1_21022001_1 - 0.00084 19.1 0.0 0.0012 18.6 0.0 1.1 1 0 0 1 1 1 1 Marek's disease glycoprotein A C2-set_2 PF08205.10 001142814.1_21022001_1 - 0.0024 17.8 0.0 0.0042 17.0 0.0 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain zf-H2C2_2 PF13465.4 001309178.1_21025001_1 - 3.6e-68 223.0 95.5 1e-08 35.1 0.6 13.6 12 1 0 12 12 11 10 Zinc-finger double domain zf-C2H2 PF00096.24 001309178.1_21025001_1 - 6.9e-54 177.3 89.2 6.5e-07 29.3 1.1 12.8 12 0 0 12 12 12 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001309178.1_21025001_1 - 3.1e-30 102.1 90.5 0.0021 18.6 0.7 12.4 13 0 0 13 13 11 9 C2H2-type zinc finger KRAB PF01352.25 001309178.1_21025001_1 - 2.6e-23 81.3 0.4 5.8e-23 80.2 0.4 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 001309178.1_21025001_1 - 1.9e-10 40.3 84.6 0.027 14.3 1.1 12.7 13 0 0 13 13 12 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001309178.1_21025001_1 - 7.6e-10 38.6 47.1 0.0014 18.6 1.5 8.5 5 2 3 8 8 8 5 Zinc ribbon domain zf-C2H2_11 PF16622.3 001309178.1_21025001_1 - 5.9e-06 25.8 40.9 2.9 7.6 0.3 9.7 9 0 0 9 9 9 4 zinc-finger C2H2-type zf-AN1 PF01428.14 001309178.1_21025001_1 - 0.00021 21.2 71.8 0.3 11.1 6.4 11.2 7 2 3 10 10 10 4 AN1-like Zinc finger zf-trcl PF13451.4 001309178.1_21025001_1 - 0.042 13.6 48.2 3.3 7.5 0.3 10.4 10 0 0 10 10 10 0 Probable zinc-ribbon domain ADK_lid PF05191.12 001309178.1_21025001_1 - 0.085 12.8 36.5 0.088 12.7 1.1 7.9 7 1 0 7 7 6 0 Adenylate kinase, active site lid zf-C2H2_jaz PF12171.6 001309178.1_21025001_1 - 0.59 10.4 47.5 2.6 8.3 0.0 10.4 9 0 0 9 9 9 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 001309178.1_21025001_1 - 0.74 9.5 72.8 0.1 12.2 0.5 11.4 9 3 0 9 9 9 0 C2H2-type zinc-finger domain CpXC PF14353.4 001309178.1_21025001_1 - 0.91 9.4 37.2 4.9 7.1 1.6 8.8 2 1 3 7 7 7 0 CpXC protein LIM PF00412.20 001309178.1_21025001_1 - 2.3 8.4 58.5 0.4 10.8 2.9 8.4 2 2 6 9 9 9 0 LIM domain zf-C2HE PF16278.3 001309178.1_21025001_1 - 4.3 7.8 75.9 0.98 9.8 1.0 10.6 2 1 6 8 8 8 0 C2HE / C2H2 / C2HC zinc-binding finger zinc_ribbon_9 PF14369.4 001309178.1_21025001_1 - 8.1 6.7 33.9 5.6 7.2 0.0 8.9 8 1 1 9 9 9 0 zinc-ribbon zf-met PF12874.5 001309178.1_21025001_1 - 9.6 6.6 75.0 0.41 11.0 2.5 11.1 11 0 0 11 11 11 0 Zinc-finger of C2H2 type Sds3 PF08598.9 001309178.1_21025001_2 - 0.018 14.9 0.3 0.034 14.0 0.3 1.4 1 0 0 1 1 1 0 Sds3-like Methyltransf_23 PF13489.4 001195829.1_06522001_2 - 0.008 16.0 0.0 0.015 15.1 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.4 001195829.1_06522001_2 - 0.049 14.2 0.0 0.097 13.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.10 001195829.1_06522001_2 - 0.051 14.1 0.0 0.096 13.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Acyltransferase PF01553.19 001309262.1_21023001_3 - 9.7e-10 38.1 0.0 2e-09 37.1 0.0 1.5 1 1 0 1 1 1 1 Acyltransferase DAGAT PF03982.11 001309262.1_21023001_3 - 0.00026 19.9 0.0 0.00042 19.2 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol acyltransferase 7tm_1 PF00001.19 001127352.1_21023001_1 - 2.4e-25 89.2 2.5 3.2e-25 88.8 2.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001127352.1_21023001_1 - 1.4e-05 24.4 1.7 1.4e-05 24.4 1.7 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.7 001127352.1_21023001_1 - 0.0024 17.2 1.7 0.0037 16.5 1.7 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srb PF02175.14 001127352.1_21023001_1 - 0.0028 17.3 0.9 0.0053 16.4 0.9 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srb Crystallin PF00525.16 001164011.1_21022001_1 - 4.6e-27 93.9 2.4 7.6e-27 93.2 2.4 1.4 1 0 0 1 1 1 1 Alpha crystallin A chain, N terminal HSP20 PF00011.19 001164011.1_21022001_1 - 1.9e-22 79.2 0.0 2.3e-22 78.9 0.0 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Lipase PF00151.17 001163949.1_21023001_1 - 4.5e-160 532.3 0.0 5.4e-160 532.1 0.0 1.0 1 0 0 1 1 1 1 Lipase PLAT PF01477.21 001163949.1_21023001_1 - 1.2e-16 61.2 0.3 2.2e-16 60.3 0.3 1.5 1 0 0 1 1 1 1 PLAT/LH2 domain Abhydrolase_6 PF12697.5 001163949.1_21023001_1 - 0.0026 18.3 0.0 0.0042 17.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF900 PF05990.10 001163949.1_21023001_1 - 0.018 14.4 0.1 0.028 13.8 0.1 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Ets PF00178.20 001192029.1_06525001_1 - 4.7e-34 116.6 1.5 8.5e-34 115.8 1.5 1.4 1 0 0 1 1 1 1 Ets-domain Elf-1_N PF12310.6 001192029.1_06525001_1 - 9.2e-33 113.0 0.1 1.7e-32 112.1 0.1 1.5 1 0 0 1 1 1 1 Transcription factor protein N terminal PGK PF00162.17 001123035.2_06524001_3 - 2.6e-151 503.8 0.2 3e-151 503.6 0.2 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase 7tm_1 PF00001.19 001257167.1_21023001_1 - 9e-47 159.4 7.7 2.7e-46 157.9 7.7 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) UPF0182 PF03699.11 001257167.1_21023001_1 - 2 6.3 6.0 2.8 5.8 6.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) DUF4644 PF15486.4 001206478.1_06522001_2 - 5.4e-89 295.9 9.1 1e-88 295.0 9.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4644) Lipocalin PF00061.21 001082509.2_21022001_1 - 8e-32 110.3 1.4 9.6e-32 110.0 1.4 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family PAR1 PF06521.9 001082509.2_21022001_1 - 0.15 11.6 0.1 0.25 10.8 0.1 1.4 1 0 0 1 1 1 0 PAR1 protein LAMTOR PF15454.4 001282070.1_21022001_1 - 2.3e-20 72.8 0.3 4e-20 72.1 0.3 1.3 1 0 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator DSPc PF00782.18 001193128.1_06523001_2 - 5.2e-38 129.7 0.0 7e-38 129.3 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 001193128.1_06523001_2 - 0.034 13.6 0.0 0.049 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase NEMP PF10225.7 001309214.1_21029001_3 - 1.9e-89 299.5 6.8 3.1e-89 298.9 6.8 1.3 1 0 0 1 1 1 1 NEMP family DUF4712 PF15830.3 001308948.1_21022001_1 - 1.4e-140 467.1 2.0 1.6e-140 466.9 2.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4712) Filament PF00038.19 001346161.1_21024001_2 - 9e-107 357.1 38.6 1e-106 356.9 38.6 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 001346161.1_21024001_2 - 0.006 16.5 2.8 0.006 16.5 2.8 4.0 3 1 0 3 3 3 1 TPR/MLP1/MLP2-like protein Lipoprotein_7 PF01540.14 001346161.1_21024001_2 - 0.0098 15.1 0.0 0.025 13.7 0.0 1.6 1 1 0 1 1 1 1 Adhesin lipoprotein Lzipper-MIP1 PF14389.4 001346161.1_21024001_2 - 0.011 15.9 4.6 0.011 15.9 4.6 4.5 3 2 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 Gp58 PF07902.9 001346161.1_21024001_2 - 0.015 13.7 14.3 0.017 13.5 13.5 1.4 1 1 0 1 1 1 0 gp58-like protein Baculo_PEP_C PF04513.10 001346161.1_21024001_2 - 0.085 12.8 21.1 2.8 7.8 12.1 3.2 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus TNF PF00229.16 001346161.1_21024001_2 - 0.096 12.5 4.2 0.45 10.3 0.1 2.9 3 0 0 3 3 3 0 TNF(Tumour Necrosis Factor) family DUF4677 PF15726.3 001346161.1_21024001_2 - 0.13 12.3 0.1 1.2 9.1 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4677) Spc7 PF08317.9 001346161.1_21024001_2 - 0.14 10.9 31.5 0.4 9.4 11.5 2.3 1 1 0 2 2 2 0 Spc7 kinetochore protein Uso1_p115_C PF04871.11 001346161.1_21024001_2 - 0.22 11.7 21.6 0.47 10.7 5.4 2.9 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF4407 PF14362.4 001346161.1_21024001_2 - 0.67 9.1 17.7 1 8.5 7.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.8 001346161.1_21024001_2 - 1.3 9.1 26.0 2.7 8.0 10.2 3.6 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family CREPT PF16566.3 001346161.1_21024001_2 - 1.9 8.5 25.4 3.2 7.8 3.6 3.4 2 1 1 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour DivIC PF04977.13 001346161.1_21024001_2 - 2 8.1 27.3 5 6.8 0.7 5.6 6 0 0 6 6 6 0 Septum formation initiator DUF1664 PF07889.10 001346161.1_21024001_2 - 2.1 8.2 19.0 3.1 7.7 1.3 3.9 1 1 2 4 4 4 0 Protein of unknown function (DUF1664) ADIP PF11559.6 001346161.1_21024001_2 - 2.5 8.0 34.9 3.2 7.7 14.4 3.5 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding FliD_C PF07195.10 001346161.1_21024001_2 - 3.2 7.0 10.0 6.4 6.0 7.2 2.5 2 1 1 3 3 3 0 Flagellar hook-associated protein 2 C-terminus zf-C4H2 PF10146.7 001346161.1_21024001_2 - 5.1 7.2 20.2 0.79 9.8 2.1 3.6 1 1 0 3 3 3 0 Zinc finger-containing protein DUF5082 PF16888.3 001346161.1_21024001_2 - 8.3 6.6 23.2 2.9 8.1 9.3 4.0 2 2 1 3 3 3 0 Domain of unknown function (DUF5082) 7tm_1 PF00001.19 001204497.1_21023001_1 - 2.7e-29 102.1 0.0 6.1e-29 100.9 0.0 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001204497.1_21023001_1 - 0.0012 18.6 0.0 0.0016 18.1 0.0 1.2 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srv PF10323.7 001204497.1_21023001_1 - 0.011 14.9 0.2 0.017 14.4 0.2 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv Defensin_propep PF00879.16 001166236.1_21021001_1 - 5.4e-22 77.7 0.6 7.3e-22 77.3 0.6 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166236.1_21021001_1 - 0.0031 17.9 10.9 0.0046 17.3 10.9 1.3 1 0 0 1 1 1 1 Mammalian defensin MscL PF01741.16 001309191.1_21024001_1 - 0.48 10.6 3.8 0.65 10.2 0.6 2.2 2 0 0 2 2 2 0 Large-conductance mechanosensitive channel, MscL Nup35_RRM PF05172.11 001309191.1_21024001_3 - 1.2e-26 92.5 0.0 1.8e-26 91.9 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.4 001309191.1_21024001_3 - 9.2e-10 38.2 0.0 1.4e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif MoaC PF01967.19 001166297.1_06526001_1 - 5e-47 159.1 2.2 7.4e-47 158.6 2.2 1.3 1 0 0 1 1 1 1 MoaC family Mob_synth_C PF06463.11 001166297.1_06526001_1 - 2e-41 140.7 0.0 3.2e-41 140.1 0.0 1.3 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.19 001166297.1_06526001_1 - 3.6e-30 105.4 0.0 5.6e-30 104.8 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.4 001166297.1_06526001_1 - 9.5e-09 35.5 0.0 1.8e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.4 001166297.1_06526001_1 - 0.0002 21.3 0.0 0.00049 20.1 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain Defensin_propep PF00879.16 001166232.1_21021001_1 - 1.7e-23 82.6 1.4 2.4e-23 82.1 1.4 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_beta PF00711.17 001166232.1_21021001_1 - 3.8 7.5 12.2 5.9 6.9 12.2 1.3 1 0 0 1 1 1 0 Beta defensin Cyclin_N PF00134.21 001309189.1_21023001_1 - 7.9e-37 125.8 0.5 1.2e-36 125.2 0.5 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 001309189.1_21023001_1 - 9.5e-19 67.5 0.0 3.7e-18 65.6 0.0 2.0 2 1 0 2 2 2 1 Cyclin, C-terminal domain K-cyclin_vir_C PF09080.8 001309189.1_21023001_1 - 0.0077 16.5 0.0 0.012 15.9 0.0 1.3 1 0 0 1 1 1 1 K cyclin, C terminal Colipase_C PF02740.12 001164015.1_21021001_1 - 1.2e-25 89.2 4.1 2.3e-25 88.4 4.1 1.4 1 0 0 1 1 1 1 Colipase, C-terminal domain Colipase PF01114.16 001164015.1_21021001_1 - 1.8e-25 88.2 6.7 1.8e-25 88.2 6.7 1.9 2 0 0 2 2 2 1 Colipase, N-terminal domain Colipase-like PF15083.4 001164015.1_21021001_1 - 0.058 13.4 8.1 0.082 12.9 8.1 1.2 1 0 0 1 1 1 0 Colipase-like DIM PF08194.10 001164015.1_21021001_1 - 0.065 13.3 3.1 0.11 12.6 1.0 2.2 2 0 0 2 2 2 0 DIM protein RBB1NT PF08169.9 001206133.2_06529001_3 - 1.3e-35 121.4 0.2 4.6e-35 119.6 0.2 2.0 1 0 0 1 1 1 1 RBB1NT (NUC162) domain ARID PF01388.19 001206133.2_06529001_3 - 2.1e-20 73.0 0.1 4.2e-20 72.1 0.1 1.5 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Tudor-knot PF11717.6 001206133.2_06529001_3 - 3.2e-11 42.8 0.4 3.2e-11 42.8 0.4 2.1 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain 7tm_1 PF00001.19 001256972.1_21023001_2 - 8.2e-36 123.5 36.1 4.3e-35 121.1 36.1 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001256972.1_21023001_2 - 6.3e-12 45.7 20.4 1.3e-11 44.6 14.3 2.5 2 2 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001256972.1_21023001_2 - 3.1e-06 26.6 32.5 7.5e-06 25.4 32.5 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001256972.1_21023001_2 - 4.1 6.5 35.3 0.04 13.1 21.4 2.4 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx Sugar_tr PF00083.22 001076324.2_06524001_1 - 1.9e-28 99.4 25.9 3.2e-28 98.7 25.9 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001076324.2_06524001_1 - 3.7e-24 85.2 36.5 3.1e-14 52.5 20.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily KH_1 PF00013.27 001256921.1_21024001_2 - 3.5e-51 170.7 14.5 1.3e-17 63.3 0.9 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.15 001256921.1_21024001_2 - 2.5e-15 55.9 4.9 0.0005 19.7 0.6 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.4 001256921.1_21024001_2 - 2.8e-07 30.2 2.9 0.056 13.2 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.4 001256921.1_21024001_2 - 0.00053 19.9 8.8 1.2 9.1 0.2 3.3 3 0 0 3 3 3 3 NusA-like KH domain Bac_chlorC PF02043.15 001256921.1_21024001_2 - 0.057 13.3 0.0 0.17 11.8 0.0 1.7 1 0 0 1 1 1 0 Bacteriochlorophyll C binding protein fn3 PF00041.19 001278571.1_06525001_1 - 4.7e-07 29.9 0.6 1.3e-06 28.5 0.3 2.0 2 0 0 2 2 2 1 Fibronectin type III domain Ig_3 PF13927.4 001278571.1_06525001_1 - 0.0003 21.2 0.1 0.0021 18.5 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 001278571.1_06525001_1 - 0.0011 19.2 0.0 0.0029 17.8 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001278571.1_06525001_1 - 0.038 14.0 0.0 0.83 9.7 0.0 2.5 2 0 0 2 2 2 0 Immunoglobulin domain Ion_trans PF00520.29 001257074.1_21023001_1 - 1.7e-47 161.6 7.7 2.2e-47 161.2 7.7 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 001257074.1_21023001_1 - 1.1e-19 70.4 0.0 2.9e-19 69.1 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 001257074.1_21023001_1 - 1.5e-12 47.1 2.3 1.5e-12 47.1 2.3 1.9 2 0 0 2 2 2 1 Ion channel PKD_channel PF08016.10 001257074.1_21023001_1 - 0.00022 19.9 2.1 0.00025 19.7 1.2 1.4 1 1 0 1 1 1 1 Polycystin cation channel zf-C3HC4_2 PF13923.4 001257074.1_21023001_1 - 0.84 9.4 3.8 2 8.2 0.2 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Defensin_propep PF00879.16 001166235.1_21021001_1 - 5.6e-21 74.5 4.6 7.1e-21 74.2 4.6 1.1 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166235.1_21021001_1 - 0.00017 21.9 9.7 0.00017 21.9 9.7 1.8 2 0 0 2 2 2 1 Mammalian defensin DUF3357 PF11837.6 001166235.1_21021001_1 - 0.13 12.6 0.0 0.15 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) PDEase_I PF00233.17 001242504.1_21026001_2 - 1.1e-92 310.0 3.9 1.1e-92 310.0 3.9 1.8 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase TAF1D PF15333.4 001309179.1_21022001_1 - 1.6e-110 367.9 5.3 2.2e-110 367.5 5.3 1.1 1 0 0 1 1 1 1 TATA box-binding protein-associated factor 1D mTERF PF02536.12 001257169.1_21023001_2 - 2.3e-29 102.2 9.2 2.7e-24 85.6 6.0 2.1 1 1 1 2 2 2 2 mTERF XPC-binding PF09280.9 001257169.1_21023001_2 - 1.1 8.9 4.9 9.2 6.0 0.0 4.0 5 0 0 5 5 5 0 XPC-binding domain CoA_trans PF01144.21 001309306.1_21028001_1 - 1.9e-123 409.8 1.4 9.6e-76 253.8 0.2 2.1 2 0 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.4 001309306.1_21028001_1 - 0.0094 15.8 0.1 0.017 14.9 0.1 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain HMG_box_2 PF09011.8 001081835.2_21025001_1 - 9.3e-42 141.4 14.3 2.3e-26 92.0 8.3 2.5 2 0 0 2 2 2 2 HMG-box domain HMG_box PF00505.17 001081835.2_21025001_1 - 7e-40 135.2 13.1 1.9e-26 92.1 0.7 2.6 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_5 PF14887.4 001081835.2_21025001_1 - 0.031 14.1 12.9 0.59 10.0 2.2 2.3 2 0 0 2 2 2 0 HMG (high mobility group) box 5 Nucleo_P87 PF07267.9 001081835.2_21025001_1 - 0.31 9.7 9.1 0.37 9.4 9.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 ANAPC15 PF15243.4 001081835.2_21025001_1 - 3.8 7.8 21.0 7.2 7.0 21.0 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 Pox_Ag35 PF03286.12 001081835.2_21025001_1 - 6.5 6.4 18.9 15 5.2 18.9 1.6 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Astro_capsid_p PF12226.6 001081835.2_21025001_1 - 8.1 5.4 17.4 11 4.9 17.4 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Nop14 PF04147.10 001081835.2_21025001_1 - 9.3 4.2 26.1 12 3.8 26.1 1.1 1 0 0 1 1 1 0 Nop14-like family DUF106 PF01956.14 001081835.2_21025001_2 - 0.0047 16.5 5.1 0.0079 15.8 5.1 1.3 1 0 0 1 1 1 1 Integral membrane protein DUF106 Sod_Cu PF00080.18 001081826.3_21022001_1 - 1.5e-46 157.9 7.4 1.9e-46 157.6 7.4 1.1 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Calc_CGRP_IAPP PF00214.17 001193200.1_06521001_1 - 5e-07 30.0 0.0 6.3e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family Cullin PF00888.20 001301216.1_21029001_1 - 9.6e-175 582.5 23.3 1.2e-174 582.2 23.3 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.7 001301216.1_21029001_1 - 2.3e-26 91.5 4.7 2.3e-26 91.5 4.7 2.7 3 0 0 3 3 3 1 Cullin protein neddylation domain Rio2_N PF09202.9 001301216.1_21029001_1 - 0.0086 16.1 1.1 0.021 14.9 0.2 2.0 2 0 0 2 2 2 1 Rio2, N-terminal zf-H2C2_2 PF13465.4 001206007.1_06523001_1 - 3e-17 62.1 24.3 5.7e-09 35.9 1.3 4.8 4 1 0 4 4 4 4 Zinc-finger double domain zf-C2H2 PF00096.24 001206007.1_06523001_1 - 4.1e-16 58.3 28.5 0.00065 19.9 4.7 4.6 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001206007.1_06523001_1 - 6.3e-09 35.8 27.3 0.00078 19.9 1.6 4.6 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001206007.1_06523001_1 - 0.00031 20.5 20.6 0.023 14.5 2.7 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001206007.1_06523001_1 - 0.044 14.0 12.0 0.8 10.0 0.5 3.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding FYVE PF01363.19 001206007.1_06523001_1 - 0.15 12.1 20.0 91 3.2 20.0 2.5 1 1 0 1 1 1 0 FYVE zinc finger zf-met PF12874.5 001206007.1_06523001_1 - 0.19 12.0 19.9 0.099 12.9 3.3 4.6 3 1 1 4 4 4 0 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.4 001206007.1_06523001_1 - 0.25 11.0 0.2 0.25 11.0 0.2 5.2 5 2 0 5 5 4 0 C2H2-type zinc-finger domain ADK_lid PF05191.12 001206007.1_06523001_1 - 0.49 10.3 10.3 0.47 10.4 3.6 3.3 3 0 0 3 3 3 0 Adenylate kinase, active site lid DUF2256 PF10013.7 001206007.1_06523001_1 - 1.1 9.3 5.8 23 5.1 0.3 3.5 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) XPA_N PF01286.16 001206007.1_06523001_1 - 1.4 8.9 9.9 17 5.4 0.0 4.1 4 0 0 4 4 4 0 XPA protein N-terminal FpoO PF10621.7 001206007.1_06523001_1 - 1.7 8.8 7.3 0.4 10.9 1.3 2.3 1 1 1 2 2 2 0 F420H2 dehydrogenase subunit FpoO zinc_ribbon_15 PF17032.3 001206007.1_06523001_1 - 2.1 9.0 10.7 1.3 9.7 1.2 2.4 1 1 1 2 2 2 0 zinc-ribbon family A2L_zn_ribbon PF08792.8 001206007.1_06523001_1 - 5.2 6.8 7.6 1.5 8.5 0.1 3.1 3 0 0 3 3 3 0 A2L zinc ribbon domain Ras PF00071.20 001309170.1_21024001_1 - 7.5e-57 191.3 0.4 1.1e-56 190.8 0.1 1.4 2 0 0 2 2 2 1 Ras family Roc PF08477.11 001309170.1_21024001_1 - 8.8e-21 74.2 0.0 6e-20 71.5 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001309170.1_21024001_1 - 4.1e-08 32.7 0.0 5.7e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001309170.1_21024001_1 - 2.1e-05 24.0 0.1 8.6e-05 22.0 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain DUF258 PF03193.14 001309170.1_21024001_1 - 5.9e-05 22.9 0.0 0.11 12.2 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 001309170.1_21024001_1 - 0.00068 19.6 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.16 001309170.1_21024001_1 - 0.017 14.5 0.0 0.076 12.4 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B Ig_2 PF13895.4 001256845.1_21022001_1 - 1.6e-15 57.0 0.0 1.3e-08 34.9 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001256845.1_21022001_1 - 5.4e-11 42.8 0.1 9e-05 22.9 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001256845.1_21022001_1 - 5.7e-08 32.7 0.0 0.00028 20.9 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin domain LRR_8 PF13855.4 001256956.1_21025001_1 - 2.1e-61 203.4 74.3 1.4e-13 50.2 1.3 6.4 1 1 7 8 8 8 8 Leucine rich repeat LRR_4 PF12799.5 001256956.1_21025001_1 - 1.1e-27 95.3 29.4 0.00034 20.8 0.1 7.4 6 1 1 7 7 7 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001256956.1_21025001_1 - 3.5e-23 81.8 0.0 6.2e-09 35.8 0.0 2.9 1 1 3 4 4 4 4 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001256956.1_21025001_1 - 3.6e-14 52.5 16.0 0.00091 18.6 1.6 5.1 1 1 5 6 6 6 6 Leucine-rich repeat I-set PF07679.14 001256956.1_21025001_1 - 1.2e-12 47.6 0.0 2.2e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001256956.1_21025001_1 - 3.7e-11 43.3 0.0 8.1e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.31 001256956.1_21025001_1 - 3.1e-07 29.8 22.8 0.76 10.3 0.1 9.3 9 2 1 10 10 10 4 Leucine Rich Repeat Ig_2 PF13895.4 001256956.1_21025001_1 - 1.1e-06 28.7 0.0 2.2e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001256956.1_21025001_1 - 2e-06 27.7 0.0 4.2e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRRCT PF01463.22 001256956.1_21025001_1 - 0.0013 19.0 0.6 0.0094 16.3 0.6 2.7 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain V-set PF07686.15 001256956.1_21025001_1 - 0.0019 18.2 0.0 0.29 11.2 0.0 2.4 1 1 0 1 1 1 1 Immunoglobulin V-set domain LRRNT PF01462.16 001256956.1_21025001_1 - 0.002 17.6 3.1 0.002 17.6 3.1 2.2 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain ESR1_C PF12743.5 001256956.1_21025001_3 - 0.22 11.2 3.0 0.55 9.9 3.0 1.6 1 0 0 1 1 1 0 Oestrogen-type nuclear receptor final C-terminal IMS PF00817.18 001301323.1_21029001_1 - 1.8e-50 170.7 0.0 2.7e-50 170.1 0.0 1.3 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.6 001301323.1_21029001_1 - 5.2e-07 30.3 0.0 1e-06 29.3 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.6 001301323.1_21029001_1 - 0.042 14.0 0.1 0.11 12.7 0.1 1.8 1 0 0 1 1 1 0 IMS family HHH motif Mod_r PF07200.11 001256913.1_21024001_3 - 0.078 12.9 0.0 0.66 9.9 0.0 2.2 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein V1R PF03402.12 001167525.1_21022001_1 - 4.2e-18 65.8 15.6 5.4e-18 65.4 15.6 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167525.1_21022001_1 - 0.0015 17.7 20.9 0.0033 16.6 20.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Kelch_1 PF01344.23 001257143.1_21024001_2 - 5.1e-56 185.9 9.1 1.1e-10 40.8 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 001257143.1_21024001_2 - 1.6e-34 116.9 7.9 2.5e-08 33.8 0.0 7.1 2 2 4 6 6 6 5 Kelch motif BACK PF07707.13 001257143.1_21024001_2 - 6.8e-26 90.2 0.1 1.4e-25 89.2 0.1 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.29 001257143.1_21024001_2 - 1.5e-24 86.3 0.2 6e-24 84.3 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.13 001257143.1_21024001_2 - 2.4e-23 81.0 4.6 1.1e-05 25.1 0.0 6.5 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.4 001257143.1_21024001_2 - 4.5e-23 80.8 2.9 6.4e-07 29.4 0.0 6.3 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.4 001257143.1_21024001_2 - 1.2e-17 63.4 1.1 0.001 18.8 0.0 5.6 4 1 1 5 5 5 5 Galactose oxidase, central domain Kelch_5 PF13854.4 001257143.1_21024001_2 - 1.8e-11 43.6 13.6 0.0063 16.3 0.5 5.7 5 0 0 5 5 5 4 Kelch motif PQQ_3 PF13570.4 001257143.1_21024001_2 - 0.00035 20.8 1.8 5.9 7.4 0.0 4.6 5 0 0 5 5 5 1 PQQ-like domain V1R PF03402.12 001166872.2_21023001_1 - 3.8e-38 131.5 16.5 5e-38 131.1 16.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001166872.2_21023001_1 - 5.6e-12 45.3 14.5 7.4e-12 44.9 14.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001166872.2_21023001_1 - 8.4e-06 25.0 17.5 1.1e-05 24.5 17.5 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) PTPLA PF04387.12 001166872.2_21023001_1 - 0.025 14.2 0.3 0.025 14.2 0.3 2.0 2 0 0 2 2 2 0 Protein tyrosine phosphatase-like protein, PTPLA Pex24p PF06398.9 001166872.2_21023001_1 - 4.8 5.9 11.0 14 4.3 11.0 1.9 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin ANP PF00212.16 001166570.1_06522001_1 - 3.6e-15 55.7 7.4 3.6e-15 55.7 7.4 2.2 3 0 0 3 3 3 1 Atrial natriuretic peptide CD20 PF04103.13 001309429.1_21026001_1 - 2.5e-46 157.5 1.5 3.9e-46 156.8 1.5 1.3 1 0 0 1 1 1 1 CD20-like family Ion_trans_2 PF07885.14 001205890.1_06524001_2 - 1.4e-29 101.8 19.6 4e-16 58.6 5.4 2.7 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.29 001205890.1_06524001_2 - 0.00011 21.4 8.2 0.016 14.3 0.1 2.3 2 0 0 2 2 2 2 Ion transport protein Thyroglobulin_1 PF00086.16 001308602.1_21024001_3 - 6.9e-23 80.0 2.5 1.3e-22 79.1 2.5 1.5 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat IGFBP PF00219.16 001308602.1_21024001_3 - 5.6e-07 30.0 20.9 5.6e-07 30.0 20.9 2.0 2 0 0 2 2 2 1 Insulin-like growth factor binding protein DUF1242 PF06842.10 001286854.1_21022001_1 - 2.5e-19 68.6 2.9 5.1e-19 67.6 2.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) NUP50 PF08911.9 001309318.1_21025001_2 - 1.5e-20 73.4 4.4 6.8e-20 71.3 4.4 2.2 1 1 0 1 1 1 1 NUP50 (Nucleoporin 50 kDa) Ran_BP1 PF00638.16 001309318.1_21025001_2 - 6.4e-11 42.4 0.0 1e-10 41.8 0.0 1.3 1 0 0 1 1 1 1 RanBP1 domain Filament PF00038.19 001346137.1_21025001_2 - 1.5e-115 386.0 34.5 1.7e-115 385.7 34.5 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001346137.1_21025001_2 - 9e-40 136.3 44.0 9e-40 136.3 44.0 2.5 2 0 0 2 2 2 1 Keratin type II head TPR_MLP1_2 PF07926.10 001346137.1_21025001_2 - 6.3e-07 29.4 30.2 0.00011 22.2 1.1 3.7 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein Gp58 PF07902.9 001346137.1_21025001_2 - 0.00048 18.6 8.9 0.0007 18.0 8.9 1.3 1 0 0 1 1 1 1 gp58-like protein Spc7 PF08317.9 001346137.1_21025001_2 - 0.00049 18.9 30.9 0.0014 17.4 5.9 2.9 1 1 1 2 2 2 2 Spc7 kinetochore protein AAA_13 PF13166.4 001346137.1_21025001_2 - 0.0015 17.2 19.0 0.0018 16.9 18.0 1.6 1 1 0 1 1 1 1 AAA domain CENP-F_leu_zip PF10473.7 001346137.1_21025001_2 - 0.0019 18.1 23.1 0.014 15.2 5.4 3.2 1 1 2 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Reo_sigmaC PF04582.10 001346137.1_21025001_2 - 0.0043 16.4 5.5 0.16 11.2 0.4 2.5 1 1 0 2 2 2 2 Reovirus sigma C capsid protein Alanine_zipper PF11839.6 001346137.1_21025001_2 - 0.0047 17.0 4.2 0.0047 17.0 4.2 2.2 2 0 0 2 2 2 1 Alanine-zipper, major outer membrane lipoprotein Jnk-SapK_ap_N PF09744.7 001346137.1_21025001_2 - 0.011 15.9 3.4 0.011 15.9 3.4 3.4 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 ADIP PF11559.6 001346137.1_21025001_2 - 0.027 14.4 23.0 0.016 15.2 5.9 3.4 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding UPF0184 PF03670.11 001346137.1_21025001_2 - 0.064 13.5 2.3 0.23 11.7 0.1 2.8 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0184) DUF1192 PF06698.9 001346137.1_21025001_2 - 0.073 13.0 3.6 0.59 10.1 0.3 3.2 3 1 0 3 3 2 0 Protein of unknown function (DUF1192) IncA PF04156.12 001346137.1_21025001_2 - 0.081 12.6 28.4 0.1 12.2 10.1 3.4 1 1 1 2 2 2 0 IncA protein Golgin_A5 PF09787.7 001346137.1_21025001_2 - 0.083 12.2 26.6 0.03 13.7 8.4 2.9 1 1 3 4 4 4 0 Golgin subfamily A member 5 DUF745 PF05335.11 001346137.1_21025001_2 - 0.098 12.3 17.4 0.86 9.2 10.3 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF745) Virulence_fact PF13769.4 001346137.1_21025001_2 - 0.1 12.6 5.3 3 7.9 0.0 3.3 2 1 1 3 3 3 0 Virulence factor UME PF08064.11 001346137.1_21025001_2 - 0.15 11.9 0.1 0.39 10.5 0.1 1.6 1 0 0 1 1 1 0 UME (NUC010) domain DUF4407 PF14362.4 001346137.1_21025001_2 - 0.23 10.6 21.3 1.4 8.1 5.9 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Baculo_PEP_C PF04513.10 001346137.1_21025001_2 - 0.59 10.0 18.5 0.56 10.1 1.7 3.8 1 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF883 PF05957.11 001346137.1_21025001_2 - 0.6 10.6 15.6 1.2 9.6 3.9 4.0 3 1 1 4 4 3 0 Bacterial protein of unknown function (DUF883) Fib_alpha PF08702.8 001346137.1_21025001_2 - 0.65 10.1 25.2 0.12 12.4 2.2 3.9 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.10 001346137.1_21025001_2 - 0.88 9.4 15.5 1.5 8.7 1.4 4.0 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) DASH_Duo1 PF08651.8 001346137.1_21025001_2 - 0.99 9.1 9.2 0.94 9.2 0.9 3.8 3 1 0 3 3 3 0 DASH complex subunit Duo1 APG6 PF04111.10 001346137.1_21025001_2 - 1.1 8.4 31.2 0.06 12.6 5.5 3.0 1 1 2 3 3 3 0 Autophagy protein Apg6 LPP PF04728.11 001346137.1_21025001_2 - 1.3 9.3 10.4 1.1 9.6 0.3 4.5 4 1 1 5 5 4 0 Lipoprotein leucine-zipper Tropomyosin_1 PF12718.5 001346137.1_21025001_2 - 1.8 8.6 26.3 0.065 13.2 9.4 3.2 2 1 1 3 3 3 0 Tropomyosin like TMF_TATA_bd PF12325.6 001346137.1_21025001_2 - 1.9 8.6 24.9 2.8 8.0 0.6 3.9 1 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding DUF1451 PF07295.9 001346137.1_21025001_2 - 3.1 7.7 14.3 1.5 8.7 3.8 2.6 2 1 0 2 2 2 0 Zinc-ribbon containing domain DUF5082 PF16888.3 001346137.1_21025001_2 - 3.4 7.9 22.8 8.5 6.6 0.5 4.4 1 1 3 4 4 4 0 Domain of unknown function (DUF5082) CHDCT2 PF08074.9 001346137.1_21025001_2 - 3.6 7.6 13.4 3.9 7.5 0.5 2.7 1 1 0 2 2 2 0 CHDCT2 (NUC038) domain PRKG1_interact PF15898.3 001346137.1_21025001_2 - 4.1 8.3 22.3 6 7.7 1.7 3.8 2 2 1 3 3 3 0 cGMP-dependent protein kinase interacting domain Rootletin PF15035.4 001346137.1_21025001_2 - 5.4 6.9 24.4 4.5 7.2 5.0 2.4 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF948 PF06103.9 001346137.1_21025001_2 - 6.4 7.0 11.7 7.8 6.7 0.9 4.2 3 2 2 6 6 5 0 Bacterial protein of unknown function (DUF948) RPW8 PF05659.9 001346137.1_21025001_2 - 6.7 6.3 11.2 9.3 5.8 0.3 3.2 2 2 1 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Phlebovirus_NSM PF07246.9 001346137.1_21025001_2 - 6.8 5.9 11.8 1.1 8.5 6.8 1.9 1 1 0 2 2 2 0 Phlebovirus nonstructural protein NS-M Bap31 PF05529.10 001346137.1_21025001_2 - 7 6.1 21.8 0.033 13.7 3.7 3.2 1 1 2 3 3 3 0 B-cell receptor-associated protein 31-like BLOC1_2 PF10046.7 001346137.1_21025001_2 - 9 6.6 19.2 1.8 8.8 0.3 4.4 1 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3522 PF12036.6 001193046.1_06523001_3 - 3.4e-43 148.0 5.7 4.1e-43 147.7 5.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3522) DUF4203 PF13886.4 001193046.1_06523001_3 - 0.81 9.2 5.3 1.2 8.6 4.3 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4203) Amelotin PF15757.3 001302953.1_06522001_2 - 1.2e-100 334.8 21.7 1.4e-100 334.6 21.7 1.0 1 0 0 1 1 1 1 Amelotin DUF4700 PF15771.3 001309215.1_21022001_1 - 0.16 10.6 0.1 0.2 10.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4700) IF4E PF01652.16 001309215.1_21022001_3 - 4.2e-60 202.0 0.1 5.4e-60 201.6 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E p450 PF00067.20 001146164.2_21024001_1 - 1.6e-125 419.4 0.4 1.8e-125 419.2 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 zf-H2C2_2 PF13465.4 001205463.1_06523001_1 - 3.8e-15 55.4 35.0 2.3e-05 24.5 1.7 5.4 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.24 001205463.1_06523001_1 - 2.8e-12 46.2 37.5 0.00026 21.1 7.6 5.0 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001205463.1_06523001_1 - 4.8e-12 45.5 31.3 0.003 18.1 1.1 4.7 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001205463.1_06523001_1 - 1.2e-06 28.1 18.5 0.00096 18.9 0.1 4.9 4 1 0 4 4 4 3 C2H2-type zinc finger zf-met2 PF12907.5 001205463.1_06523001_1 - 0.00015 21.7 0.6 0.00015 21.7 0.6 2.6 3 0 0 3 3 3 1 Zinc-binding zf-C2H2_9 PF16293.3 001205463.1_06523001_1 - 0.0014 18.3 3.7 4.7 7.0 0.0 3.4 3 0 0 3 3 3 2 C2H2 type zinc-finger (1 copy) zf-Di19 PF05605.10 001205463.1_06523001_1 - 0.0017 18.4 16.6 0.0021 18.2 0.8 3.6 1 1 3 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.6 001205463.1_06523001_1 - 0.0032 17.6 7.9 0.11 12.7 1.4 3.9 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding AT_hook PF02178.17 001205463.1_06523001_1 - 0.031 14.0 1.1 0.031 14.0 1.1 3.7 4 1 0 3 3 3 0 AT hook motif zf-met PF12874.5 001205463.1_06523001_1 - 0.13 12.6 16.2 1 9.7 4.1 4.3 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 001205463.1_06523001_1 - 7.1 6.4 14.1 6.2 6.6 3.0 3.4 3 0 0 3 3 3 0 zinc-finger C2H2-type DAO PF01266.22 001301152.1_21029001_3 - 2.8e-47 161.9 0.0 3.7e-47 161.5 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.3 001301152.1_21029001_3 - 1.3e-39 134.8 0.0 2.2e-39 134.0 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase EF-hand_7 PF13499.4 001301152.1_21029001_3 - 1.7e-10 41.1 0.7 3.3e-10 40.2 0.7 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 001301152.1_21029001_3 - 5.4e-09 34.8 0.2 0.00024 20.3 0.0 2.7 2 0 0 2 2 2 2 EF hand FAD_binding_2 PF00890.22 001301152.1_21029001_3 - 1.1e-07 31.2 0.5 3.9e-05 22.8 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain EF-hand_6 PF13405.4 001301152.1_21029001_3 - 1.2e-06 27.8 0.2 0.049 13.5 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain FAD_oxidored PF12831.5 001301152.1_21029001_3 - 1.7e-05 24.2 0.3 4e-05 23.0 0.1 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase EF-hand_8 PF13833.4 001301152.1_21029001_3 - 4e-05 23.2 0.2 0.00011 21.8 0.2 1.8 1 0 0 1 1 1 1 EF-hand domain pair GIDA PF01134.20 001301152.1_21029001_3 - 4.6e-05 22.5 0.3 0.0029 16.6 0.1 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_2 PF07992.12 001301152.1_21029001_3 - 5.9e-05 22.3 2.0 0.0046 16.1 0.2 1.9 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase EF-hand_5 PF13202.4 001301152.1_21029001_3 - 0.0038 16.6 1.0 0.87 9.1 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_9 PF14658.4 001301152.1_21029001_3 - 0.013 15.7 0.0 0.03 14.5 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain HI0933_like PF03486.12 001301152.1_21029001_3 - 0.033 12.7 0.1 0.047 12.2 0.1 1.1 1 0 0 1 1 1 0 HI0933-like protein EF-hand_10 PF14788.4 001301152.1_21029001_3 - 0.06 13.1 0.3 0.14 11.9 0.3 1.6 1 0 0 1 1 1 0 EF hand NAD_binding_8 PF13450.4 001301152.1_21029001_3 - 0.063 13.4 0.1 0.17 12.0 0.1 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.25 001301152.1_21029001_3 - 0.11 13.0 0.1 0.24 11.9 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.15 001301152.1_21029001_3 - 0.15 11.1 0.0 0.29 10.2 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.4 001301152.1_21029001_3 - 0.21 10.6 0.0 0.6 9.2 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase RhlB PF12300.6 001301152.1_21029001_3 - 5.7 7.0 9.3 13 5.8 9.3 1.5 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB Sep15_SelM PF08806.9 001168402.1_21022001_1 - 1.6e-21 76.2 0.0 2.7e-21 75.4 0.0 1.3 1 0 0 1 1 1 1 Sep15/SelM redox domain Integrin_beta PF00362.16 001301217.1_21028001_1 - 1.4e-114 381.8 0.0 1.8e-114 381.4 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.9 001301217.1_21028001_1 - 3.7e-28 96.8 6.4 2e-21 75.2 2.2 2.4 2 0 0 2 2 2 2 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.10 001301217.1_21028001_1 - 7e-22 77.6 9.2 7e-22 77.6 9.2 3.9 5 0 0 5 5 5 1 Integrin beta tail domain PSI_integrin PF17205.1 001301217.1_21028001_1 - 6.3e-12 45.0 8.3 6.3e-12 45.0 8.3 5.3 5 1 0 5 5 5 1 Integrin plexin domain EGF_2 PF07974.11 001301217.1_21028001_1 - 2.8e-07 30.7 59.2 9.9e-06 25.7 14.3 6.8 6 1 1 7 7 7 3 EGF-like domain TNF PF00229.16 001205160.1_21023001_1 - 7.8e-15 54.8 0.0 1.2e-14 54.3 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1q PF00386.19 001205160.1_21023001_1 - 0.0086 16.2 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 C1q domain NB-ARC PF00931.20 001309157.1_21028001_3 - 3.4e-78 262.5 0.2 5.9e-78 261.7 0.2 1.4 1 0 0 1 1 1 1 NB-ARC domain WD40 PF00400.30 001309157.1_21028001_3 - 1.2e-64 212.6 43.9 3.4e-08 33.9 0.4 13.6 13 0 0 13 13 13 11 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001309157.1_21028001_3 - 2.1e-31 108.0 11.0 0.00023 21.2 0.2 9.5 4 4 5 9 9 9 7 Anaphase-promoting complex subunit 4 WD40 domain CARD PF00619.19 001309157.1_21028001_3 - 1.1e-21 76.5 0.1 3.1e-21 75.1 0.1 1.9 1 0 0 1 1 1 1 Caspase recruitment domain Ge1_WD40 PF16529.3 001309157.1_21028001_3 - 1.4e-12 47.1 5.6 0.15 10.9 0.0 7.7 2 2 4 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.9 001309157.1_21028001_3 - 7.5e-12 45.4 4.6 0.0019 18.0 0.1 4.8 2 1 3 5 5 5 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.3 001309157.1_21028001_3 - 3.1e-11 43.0 2.0 0.0056 15.9 0.1 4.8 3 2 1 5 5 5 3 WD40-like domain CARD_2 PF16739.3 001309157.1_21028001_3 - 2.4e-07 30.5 0.1 7.6e-07 28.9 0.1 1.9 1 0 0 1 1 1 1 Caspase recruitment domain Utp8 PF10395.7 001309157.1_21028001_3 - 1.9e-05 23.3 0.3 0.00014 20.4 0.0 2.1 2 0 0 2 2 2 1 Utp8 family AAA_16 PF13191.4 001309157.1_21028001_3 - 7.9e-05 23.0 0.0 0.00019 21.7 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain Nbas_N PF15492.4 001309157.1_21028001_3 - 0.0043 16.3 0.4 2.1 7.5 0.0 3.7 2 2 1 4 4 4 1 Neuroblastoma-amplified sequence, N terminal NACHT PF05729.10 001309157.1_21028001_3 - 0.041 13.7 0.1 0.13 12.0 0.1 1.9 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.4 001309157.1_21028001_3 - 0.081 13.1 0.0 0.42 10.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.4 001309157.1_21028001_3 - 0.11 12.9 0.0 0.48 10.8 0.0 2.2 1 0 0 1 1 1 0 AAA domain V1R PF03402.12 001166855.1_21022001_1 - 5.6e-85 285.0 25.0 7e-85 284.7 25.0 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166855.1_21022001_1 - 3.1e-06 26.4 28.7 4e-06 26.0 28.7 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166855.1_21022001_1 - 0.83 8.7 16.6 1.7 7.7 16.2 1.8 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Beach PF02138.16 001308950.1_21029001_2 - 3.2e-112 374.3 1.2 5.6e-112 373.5 1.2 1.4 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.4 001308950.1_21029001_2 - 3.2e-22 78.4 0.0 7.8e-22 77.1 0.0 1.7 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.30 001308950.1_21029001_2 - 4.3e-07 30.4 10.4 0.086 13.6 0.0 6.1 4 1 0 4 4 4 3 WD domain, G-beta repeat DUF4800 PF16057.3 001308950.1_21029001_2 - 0.1 11.7 3.4 0.25 10.4 3.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4800) SelP_N PF04592.12 001135605.1_21025001_3 - 5.2e-106 353.2 6.9 7.1e-106 352.7 6.9 1.1 1 0 0 1 1 1 1 Selenoprotein P, N terminal region SelP_C PF04593.12 001135605.1_21025001_3 - 3.7e-30 104.5 6.1 1.1e-29 103.0 6.1 1.8 1 0 0 1 1 1 1 Selenoprotein P, C terminal region SH3_2 PF07653.15 001122656.1_21021001_1 - 1.7e-11 43.5 0.0 2.3e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.4 001122656.1_21021001_1 - 0.0034 17.1 0.0 0.0085 15.8 0.0 1.7 1 1 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001122656.1_21021001_1 - 0.058 12.9 0.0 0.17 11.4 0.0 1.7 2 0 0 2 2 2 0 SH3 domain LRAT PF04970.11 001281908.1_06524001_3 - 2e-36 124.9 0.0 4.5e-36 123.8 0.0 1.6 1 0 0 1 1 1 1 Lecithin retinol acyltransferase Peptidase_C97 PF05903.12 001281908.1_06524001_3 - 0.11 12.2 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 PPPDE putative peptidase domain 7tm_1 PF00001.19 001309169.1_21024001_1 - 8.6e-48 162.8 17.6 1.5e-47 162.0 17.6 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001309169.1_21024001_1 - 4.1e-06 26.2 12.6 4.1e-06 26.2 12.6 2.9 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001309169.1_21024001_1 - 0.015 14.9 17.9 0.21 11.1 17.9 2.2 1 1 0 1 1 1 0 Olfactory receptor IL17 PF06083.9 001143792.1_21021001_1 - 1.7e-29 101.9 1.6 6.7e-29 100.1 0.8 1.9 2 0 0 2 2 2 1 Interleukin-17 Myelin-PO_C PF10570.7 001081894.2_21023001_1 - 2.9e-36 123.6 8.3 5.2e-36 122.8 8.3 1.4 1 0 0 1 1 1 1 Myelin-PO cytoplasmic C-term p65 binding region V-set PF07686.15 001081894.2_21023001_1 - 1.4e-20 73.3 0.1 2.4e-20 72.6 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.4 001081894.2_21023001_1 - 1.5e-05 25.1 0.3 0.00026 21.1 0.3 2.5 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001081894.2_21023001_1 - 0.0001 22.3 0.2 0.00037 20.5 0.2 1.9 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 001081894.2_21023001_1 - 0.00017 22.0 0.1 0.00045 20.7 0.1 1.8 1 1 0 1 1 1 1 Immunoglobulin domain DUF1191 PF06697.10 001081894.2_21023001_1 - 0.0016 17.6 0.1 0.0022 17.1 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1191) Herpes_gE PF02480.14 001081894.2_21023001_1 - 0.012 14.3 0.6 0.096 11.3 0.8 1.9 1 1 1 2 2 2 0 Alphaherpesvirus glycoprotein E I-set PF07679.14 001081894.2_21023001_1 - 0.013 15.4 0.1 0.032 14.2 0.1 1.7 1 1 0 1 1 1 0 Immunoglobulin I-set domain Protocadherin PF08374.9 001081894.2_21023001_1 - 0.029 14.2 0.5 0.046 13.6 0.5 1.4 1 1 0 1 1 1 0 Protocadherin Amnionless PF14828.4 001081894.2_21023001_1 - 0.065 11.9 0.0 0.099 11.4 0.0 1.2 1 0 0 1 1 1 0 Amnionless Mucin15 PF15672.3 001081894.2_21023001_1 - 0.17 11.2 0.3 0.27 10.5 0.3 1.2 1 0 0 1 1 1 0 Cell-membrane associated Mucin15 HAMP PF00672.23 001081894.2_21023001_1 - 0.19 11.8 0.1 0.19 11.8 0.1 1.6 2 0 0 2 2 1 0 HAMP domain Syndecan PF01034.18 001081894.2_21023001_1 - 2 8.3 3.7 5.2 6.9 3.7 1.7 1 0 0 1 1 1 0 Syndecan domain BAG PF02179.14 001110532.1_06526001_3 - 7.1e-17 61.5 3.5 7.1e-17 61.5 3.5 1.9 2 0 0 2 2 2 1 BAG domain DUF2682 PF10909.6 001110532.1_06526001_3 - 0.091 13.1 0.1 0.21 12.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2682) PHR PF08005.10 001309249.1_21029001_2 - 2.1e-84 281.6 0.0 1e-40 139.7 0.0 2.8 2 0 0 2 2 2 2 PHR domain RCC1 PF00415.16 001309249.1_21029001_2 - 7.7e-22 77.5 24.3 2.9e-12 46.9 1.6 7.3 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 001309249.1_21029001_2 - 1.2e-21 75.8 14.0 9e-08 31.6 0.1 5.4 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat SH3_3 PF08239.9 001309249.1_21029001_2 - 6.6e-16 58.2 0.7 7.2e-08 32.5 0.0 3.6 3 0 0 3 3 3 2 Bacterial SH3 domain zf-RING_2 PF13639.4 001309249.1_21029001_2 - 1.3e-07 31.6 6.8 1.3e-07 31.6 6.8 4.8 5 1 0 5 5 5 1 Ring finger domain Filamin PF00630.17 001309249.1_21029001_2 - 2.5e-06 28.1 0.0 7.5e-06 26.6 0.0 1.8 1 0 0 1 1 1 1 Filamin/ABP280 repeat ANAPC10 PF03256.14 001309249.1_21029001_2 - 1.3e-05 24.8 0.1 3.1e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) zf-RING_11 PF17123.3 001309249.1_21029001_2 - 0.0022 17.5 7.9 0.022 14.4 7.9 2.9 1 0 0 1 1 1 1 RING-like zinc finger Ribosomal_60s PF00428.17 001309249.1_21029001_2 - 0.45 11.0 2.3 23 5.5 0.1 3.5 3 0 0 3 3 3 0 60s Acidic ribosomal protein zf-RING_UBOX PF13445.4 001309249.1_21029001_2 - 8.5 6.4 15.2 0.045 13.7 2.0 3.6 3 0 0 3 3 3 0 RING-type zinc-finger RRM_1 PF00076.20 001242509.1_21024001_1 - 8e-36 121.6 0.1 2.4e-17 62.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001242509.1_21024001_1 - 4.7e-11 42.5 0.1 5.2e-06 26.4 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.4 001242509.1_21024001_1 - 0.00022 21.0 0.2 0.1 12.4 0.1 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif zf-H2C2_5 PF13909.4 001256978.1_21027001_1 - 1e-05 25.0 0.9 1e-05 25.0 0.9 4.3 4 0 0 4 4 4 2 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.4 001256978.1_21027001_1 - 1.4e-05 25.1 0.2 1.4e-05 25.1 0.2 5.3 6 0 0 6 6 6 1 Zinc-finger double domain zf-C2H2 PF00096.24 001256978.1_21027001_1 - 0.00027 21.1 29.5 0.4 11.1 0.4 5.4 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001256978.1_21027001_1 - 0.014 16.0 21.7 0.8 10.6 2.1 5.1 4 0 0 4 4 4 0 C2H2-type zinc finger zf-nanos PF05741.11 001256978.1_21027001_1 - 6 7.0 12.7 4.3 7.5 0.2 4.4 3 1 1 4 4 4 0 Nanos RNA binding domain Fez1 PF06818.13 001191200.1_06529001_1 - 6e-60 203.0 10.2 6e-60 203.0 10.2 2.2 2 0 0 2 2 2 2 Fez1 DUF812 PF05667.9 001191200.1_06529001_1 - 4.8e-05 22.3 12.8 8.5e-05 21.5 12.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF812) ATG16 PF08614.9 001191200.1_06529001_1 - 0.0034 17.5 7.8 0.0034 17.5 7.8 3.4 2 2 2 4 4 4 2 Autophagy protein 16 (ATG16) PKcGMP_CC PF16808.3 001191200.1_06529001_1 - 1.1 9.1 14.2 0.13 12.0 3.8 3.8 3 1 1 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase HIG_1_N PF04588.11 001308955.1_21025001_1 - 8e-17 61.1 1.6 1.2e-16 60.5 1.6 1.3 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Glyco_hydro_47 PF01532.18 001205853.2_06529001_1 - 1.9e-114 383.0 0.0 2.8e-114 382.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 PA PF02225.20 001205853.2_06529001_1 - 4.8e-12 45.7 0.0 9e-12 44.8 0.0 1.4 1 0 0 1 1 1 1 PA domain APOBEC_N PF08210.9 001163936.1_06522001_2 - 1.5e-38 132.4 1.3 2.3e-38 131.8 1.3 1.2 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001163936.1_06522001_2 - 2.6e-28 97.6 0.0 5.6e-28 96.6 0.0 1.6 1 0 0 1 1 1 1 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 001163936.1_06522001_2 - 0.0039 16.9 0.0 0.2 11.4 0.0 2.2 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region V1R PF03402.12 001166857.1_21022001_1 - 1.5e-25 90.2 8.7 2e-25 89.8 8.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166857.1_21022001_1 - 1.5e-06 27.4 13.8 1.8e-06 27.2 13.8 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) TBCC PF07986.10 001309330.1_21024001_2 - 4e-37 126.5 0.2 8.1e-37 125.5 0.2 1.5 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.9 001309330.1_21024001_2 - 0.00016 21.2 0.4 0.00033 20.2 0.4 1.4 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal Fra10Ac1 PF09725.7 001308964.1_21023001_2 - 9e-52 174.2 8.2 9e-52 174.2 8.2 2.3 2 0 0 2 2 2 1 Folate-sensitive fragile site protein Fra10Ac1 SelP_N PF04592.12 001308964.1_21023001_2 - 1.6 8.0 14.8 0.037 13.3 7.5 1.8 2 0 0 2 2 2 0 Selenoprotein P, N terminal region NPR3 PF03666.11 001308964.1_21023001_2 - 5.7 5.5 13.2 9.9 4.7 13.2 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SpoIIIAH PF12685.5 001308964.1_21023001_2 - 6.9 6.3 10.8 0.42 10.3 5.7 1.6 2 0 0 2 2 2 0 SpoIIIAH-like protein Presenilin PF01080.15 001308964.1_21023001_2 - 9.6 4.7 9.7 15 4.0 9.7 1.2 1 0 0 1 1 1 0 Presenilin 7tm_1 PF00001.19 001194962.1_06523001_1 - 7.9e-45 153.0 31.2 2e-44 151.7 31.2 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001194962.1_06523001_1 - 9.8e-07 28.3 28.4 1.3e-06 27.9 28.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Histone PF00125.22 001114854.1_06521001_1 - 4.6e-24 85.2 0.1 5.9e-24 84.8 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 001114854.1_06521001_1 - 9.3e-06 25.7 0.1 2.6e-05 24.3 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.11 001114854.1_06521001_1 - 0.0052 17.1 0.0 0.0096 16.3 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.3 001114854.1_06521001_1 - 0.018 14.9 0.1 0.022 14.7 0.1 1.2 1 0 0 1 1 1 0 YscO-like protein VWA PF00092.26 001163870.1_21029001_1 - 1e-108 361.2 1.5 4.6e-53 179.9 1.4 2.7 2 0 0 2 2 2 2 von Willebrand factor type A domain fn3 PF00041.19 001163870.1_21029001_1 - 8.2e-99 324.0 14.1 9.2e-16 57.8 0.1 8.4 8 0 0 8 8 8 8 Fibronectin type III domain Collagen PF01391.16 001163870.1_21029001_1 - 1e-36 124.4 163.9 4.1e-08 32.7 23.6 5.4 2 2 3 5 5 5 5 Collagen triple helix repeat (20 copies) VWA_2 PF13519.4 001163870.1_21029001_1 - 5.7e-31 107.2 0.0 5e-17 62.4 0.0 3.3 3 0 0 3 3 3 2 von Willebrand factor type A domain DUF2369 PF10179.7 001163870.1_21029001_1 - 3.1e-09 37.0 1.3 7.5 7.0 0.0 7.8 7 1 1 8 8 8 2 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.8 001163870.1_21029001_1 - 1.4e-07 31.6 0.0 3.8 7.7 0.0 6.8 7 0 0 7 7 7 1 Interferon-alpha/beta receptor, fibronectin type III Pur_ac_phosph_N PF16656.3 001163870.1_21029001_1 - 1.4e-07 31.8 12.3 2.5 8.6 0.1 8.5 6 2 1 7 7 7 2 Purple acid Phosphatase, N-terminal domain VWA_3 PF13768.4 001163870.1_21029001_1 - 2.8e-06 27.2 0.0 0.0039 17.0 0.0 2.9 2 0 0 2 2 2 2 von Willebrand factor type A domain DUF4959 PF16323.3 001163870.1_21029001_1 - 0.00027 21.1 0.0 5.3 7.3 0.0 4.5 4 0 0 4 4 4 1 Domain of unknown function (DUF4959) fn3_2 PF16893.3 001163870.1_21029001_1 - 0.0052 16.8 0.2 1.9 8.5 0.0 4.4 6 0 0 6 6 6 1 Fibronectin type III domain Arylsulfotrans PF05935.9 001163870.1_21029001_1 - 0.024 13.3 1.6 7.6 5.0 0.0 3.8 3 1 0 4 4 4 0 Arylsulfotransferase (ASST) Collagen PF01391.16 001101867.3_06525001_3 - 6.8e-20 70.5 111.7 8.2e-10 38.2 29.0 6.7 4 2 1 5 5 5 3 Collagen triple helix repeat (20 copies) EMI PF07546.11 001101867.3_06525001_3 - 7.7e-15 55.3 11.4 1.3e-14 54.5 11.4 1.4 1 0 0 1 1 1 1 EMI domain zf-C3HC4_3 PF13920.4 001192592.1_06524001_2 - 0.00018 21.2 7.4 0.00034 20.3 7.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001192592.1_06524001_2 - 0.00061 19.5 7.6 0.0012 18.5 7.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001192592.1_06524001_2 - 0.0016 18.2 6.9 0.0032 17.3 6.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.4 001192592.1_06524001_2 - 0.0087 15.7 10.4 0.054 13.2 10.4 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001192592.1_06524001_2 - 0.057 13.3 5.0 0.16 11.9 5.0 1.8 1 0 0 1 1 1 0 RING-type zinc-finger Prok-RING_4 PF14447.4 001192592.1_06524001_2 - 0.066 12.9 6.7 0.14 11.9 6.7 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DZR PF12773.5 001192592.1_06524001_2 - 0.067 13.1 5.4 0.22 11.5 5.4 1.9 1 1 0 1 1 1 0 Double zinc ribbon zinc-ribbons_6 PF07191.10 001192592.1_06524001_2 - 0.1 12.5 9.8 0.18 11.7 9.8 1.3 1 0 0 1 1 1 0 zinc-ribbons zf-RING_2 PF13639.4 001192592.1_06524001_2 - 0.11 12.6 8.5 0.25 11.5 8.5 1.7 1 0 0 1 1 1 0 Ring finger domain zf-MIZ PF02891.18 001192592.1_06524001_2 - 0.55 9.9 5.5 1.2 8.8 5.5 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-RING_4 PF14570.4 001192592.1_06524001_2 - 5.1 6.8 8.8 0.43 10.2 3.7 1.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-B_box PF00643.22 001301294.1_21028001_1 - 1.1e-08 34.9 4.8 1.1e-08 34.9 4.8 4.1 3 1 0 3 3 3 2 B-box zinc finger zf-RING_UBOX PF13445.4 001301294.1_21028001_1 - 1.2e-08 34.7 3.0 1.2e-08 34.7 3.0 3.2 3 0 0 3 3 3 1 RING-type zinc-finger fn3 PF00041.19 001301294.1_21028001_1 - 1e-06 28.8 0.0 2e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain zf-C3HC4_4 PF15227.4 001301294.1_21028001_1 - 1.9e-05 24.6 4.4 1.9e-05 24.6 4.4 4.0 5 0 0 5 5 5 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001301294.1_21028001_1 - 3.4e-05 23.5 4.6 3.4e-05 23.5 4.6 4.3 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001301294.1_21028001_1 - 0.00037 20.3 2.1 0.00037 20.3 2.1 4.1 2 1 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.4 001301294.1_21028001_1 - 0.00052 19.7 3.8 0.00052 19.7 3.8 4.9 6 0 0 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001301294.1_21028001_1 - 0.0047 16.6 6.1 0.0047 16.6 6.1 3.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) ATP-synt_B PF00430.16 001301294.1_21028001_1 - 0.014 15.4 0.2 0.027 14.4 0.2 1.5 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) SPRY PF00622.26 001301294.1_21028001_1 - 0.014 15.4 0.0 0.028 14.4 0.0 1.4 1 0 0 1 1 1 0 SPRY domain Interferon PF00143.17 001143796.1_21022001_1 - 5e-43 146.9 2.3 6.2e-43 146.6 2.3 1.1 1 0 0 1 1 1 1 Interferon alpha/beta domain zf-C2H2 PF00096.24 001308308.1_21029001_2 - 2.9e-11 43.0 73.2 0.028 14.8 3.4 10.0 9 0 0 9 9 9 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001308308.1_21029001_2 - 8.2e-11 41.6 68.1 0.034 14.8 3.4 9.9 9 0 0 9 9 9 7 C2H2-type zinc finger zf-H2C2_2 PF13465.4 001308308.1_21029001_2 - 1.1e-06 28.7 66.2 0.00056 20.1 2.0 11.0 12 0 0 12 12 12 6 Zinc-finger double domain zf-H2C2_5 PF13909.4 001308308.1_21029001_2 - 0.0017 17.9 71.6 0.085 12.5 1.0 9.7 9 0 0 9 9 9 6 C2H2-type zinc-finger domain zf-CSL PF05207.11 001308308.1_21029001_2 - 0.11 12.2 3.4 0.074 12.7 0.2 2.3 2 0 0 2 2 2 0 CSL zinc finger zf-C2HE PF16278.3 001308308.1_21029001_2 - 0.13 12.6 0.1 0.13 12.6 0.1 5.5 6 1 0 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger GAGA PF09237.9 001308308.1_21029001_2 - 0.2 11.3 1.6 1 9.1 0.3 2.6 2 0 0 2 2 2 0 GAGA factor CEP209_CC5 PF16574.3 001308368.1_21029001_1 - 1.4e-51 173.8 24.3 1.4e-51 173.8 24.3 21.7 9 6 15 25 25 25 3 Coiled-coil region of centrosome protein CE290 Elongin_A PF06881.9 001252407.1_21025001_3 - 1e-27 96.5 0.5 1e-27 96.5 0.5 3.0 3 0 0 3 3 3 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Med26 PF08711.9 001252407.1_21025001_3 - 2.9e-13 49.5 0.1 8.4e-13 48.0 0.1 1.8 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Filament PF00038.19 001346191.1_21024001_2 - 1e-108 363.5 20.0 1.4e-108 363.1 20.0 1.0 1 0 0 1 1 1 1 Intermediate filament protein DUF4407 PF14362.4 001346191.1_21024001_2 - 0.00058 19.2 19.0 0.085 12.1 0.7 3.0 1 1 2 3 3 3 3 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.10 001346191.1_21024001_2 - 0.00074 19.5 27.4 0.0016 18.4 1.0 4.3 3 1 0 3 3 3 1 TPR/MLP1/MLP2-like protein SPATA1_C PF15743.3 001346191.1_21024001_2 - 0.14 12.1 13.3 1 9.3 0.0 3.4 1 1 1 3 3 3 0 Spermatogenesis-associated C-terminus IncA PF04156.12 001346191.1_21024001_2 - 0.17 11.5 26.7 3.6 7.2 5.5 3.2 2 1 1 3 3 3 0 IncA protein DUF972 PF06156.11 001346191.1_21024001_2 - 0.32 11.5 15.2 1.9 9.0 0.0 4.9 2 1 2 5 5 5 0 Protein of unknown function (DUF972) Prefoldin_2 PF01920.18 001346191.1_21024001_2 - 0.42 10.5 20.7 0.77 9.6 0.8 4.6 4 1 0 4 4 4 0 Prefoldin subunit DUF4446 PF14584.4 001346191.1_21024001_2 - 0.46 10.3 10.1 1.4 8.7 0.0 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF4446) Prominin PF05478.9 001346191.1_21024001_2 - 0.5 8.1 14.3 0.085 10.7 6.8 2.6 2 1 1 3 3 3 0 Prominin Atg14 PF10186.7 001346191.1_21024001_2 - 0.82 8.6 17.4 0.35 9.8 7.5 2.5 3 0 0 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3373 PF11853.6 001346191.1_21024001_2 - 0.83 8.2 10.3 12 4.3 10.3 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3373) Abdominal-A PF12407.6 001346191.1_21024001_2 - 1.2 8.7 6.6 2.4 7.7 6.6 1.5 1 0 0 1 1 1 0 Homeobox protein FlxA PF14282.4 001346191.1_21024001_2 - 1.2 9.0 28.6 1.2 9.0 7.2 4.1 3 1 1 5 5 4 0 FlxA-like protein XhlA PF10779.7 001346191.1_21024001_2 - 1.5 9.0 11.8 0.11 12.6 0.6 3.5 4 1 0 4 4 4 0 Haemolysin XhlA UPF0184 PF03670.11 001346191.1_21024001_2 - 2.2 8.6 5.4 4 7.7 0.0 3.2 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0184) ADIP PF11559.6 001346191.1_21024001_2 - 2.4 8.1 24.3 8.6 6.3 1.7 4.0 2 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding DUF1664 PF07889.10 001346191.1_21024001_2 - 2.7 7.9 13.5 4.6 7.1 1.6 3.8 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Jnk-SapK_ap_N PF09744.7 001346191.1_21024001_2 - 2.8 8.0 28.0 0.31 11.1 2.0 4.1 2 1 2 4 4 4 0 JNK_SAPK-associated protein-1 Bacillus_HBL PF05791.9 001346191.1_21024001_2 - 3.5 7.2 13.8 0.15 11.7 3.2 3.0 2 1 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) DivIC PF04977.13 001346191.1_21024001_2 - 5.8 6.6 0.0 5.8 6.6 0.0 5.1 4 1 1 5 5 5 0 Septum formation initiator RasGAP_C PF03836.13 001346191.1_21024001_2 - 6.3 6.8 22.8 0.25 11.3 1.6 3.6 2 1 1 4 4 4 0 RasGAP C-terminus CENP-F_leu_zip PF10473.7 001346191.1_21024001_2 - 8.4 6.3 30.2 0.69 9.8 0.8 4.4 3 1 1 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Parathyroid PF01279.15 001163981.1_21023001_2 - 2.1e-32 111.8 0.3 4e-32 110.9 0.3 1.4 1 0 0 1 1 1 1 Parathyroid hormone family Herpes_DNAp_acc PF04929.10 001163981.1_21023001_2 - 2.7 6.7 4.5 3.9 6.2 4.5 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor NID PF07292.11 001242511.1_21023001_1 - 6.4e-64 212.5 10.6 3.9e-33 113.8 0.1 3.1 3 0 0 3 3 3 2 Nmi/IFP 35 domain (NID) IFP_35_N PF07334.11 001242511.1_21023001_1 - 7.8e-39 131.5 7.0 1.1e-38 131.1 4.8 2.2 2 0 0 2 2 2 1 Interferon-induced 35 kDa protein (IFP 35) N-terminus DUF5016 PF16408.3 001242511.1_21023001_1 - 0.059 13.2 0.1 0.38 10.6 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5016) bZIP_2 PF07716.13 001242511.1_21023001_1 - 0.31 11.0 5.6 0.74 9.8 5.6 1.6 1 0 0 1 1 1 0 Basic region leucine zipper Spc24 PF08286.9 001242511.1_21023001_1 - 0.42 10.8 4.9 0.82 9.8 4.9 1.5 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Cnn_1N PF07989.9 001242511.1_21023001_1 - 0.58 10.2 9.5 0.064 13.3 4.2 2.2 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 IL8 PF00048.18 001081886.2_21024001_1 - 2.5e-12 46.6 0.6 5.5e-12 45.5 0.6 1.6 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like MHC_I_3 PF16497.3 001252306.1_21023001_1 - 1.3e-90 302.1 0.8 1.7e-90 301.7 0.8 1.2 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001252306.1_21023001_1 - 1.6e-11 44.4 0.0 4.8e-11 42.9 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001252306.1_21023001_1 - 2.4e-05 23.8 0.0 4.9e-05 22.8 0.0 1.5 2 0 0 2 2 2 1 Class I Histocompatibility antigen, domains alpha 1 and 2 RAG1 PF12940.5 001256901.1_21027001_1 - 0 1268.0 0.8 0 1267.4 0.8 1.2 1 0 0 1 1 1 1 Recombination-activation protein 1 (RAG1), recombinase RAG1_imp_bd PF12560.6 001256901.1_21027001_1 - 1.6e-126 421.5 12.7 3.8e-126 420.3 12.7 1.6 1 0 0 1 1 1 1 RAG1 importin binding zf-RAG1 PF10426.7 001256901.1_21027001_1 - 1.2e-17 63.6 12.2 2.2e-16 59.6 5.3 2.6 2 0 0 2 2 2 2 Recombination-activating protein 1 zinc-finger domain zf-C3HC4_2 PF13923.4 001256901.1_21027001_1 - 1.2e-07 31.4 12.9 1.2e-07 31.4 12.9 3.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001256901.1_21027001_1 - 3.1e-06 26.8 13.5 3.1e-06 26.8 13.5 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 001256901.1_21027001_1 - 0.00015 21.4 8.4 0.00015 21.4 8.4 2.4 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_2 PF13639.4 001256901.1_21027001_1 - 0.0008 19.5 13.5 0.0008 19.5 13.5 3.7 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.4 001256901.1_21027001_1 - 0.0029 17.3 15.3 0.0029 17.3 15.3 3.8 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001256901.1_21027001_1 - 0.0031 17.4 10.2 0.0031 17.4 10.2 2.6 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.4 001256901.1_21027001_1 - 0.0035 17.1 12.3 0.0035 17.1 12.3 3.2 4 0 0 4 4 4 1 zinc-RING finger domain zf-C3HC4_4 PF15227.4 001256901.1_21027001_1 - 0.0096 15.9 13.6 0.0096 15.9 13.6 3.2 4 0 0 4 4 3 1 zinc finger of C3HC4-type, RING U-box PF04564.13 001256901.1_21027001_1 - 0.021 14.9 0.2 0.52 10.4 0.0 2.7 2 0 0 2 2 2 0 U-box domain zf-rbx1 PF12678.5 001256901.1_21027001_1 - 4.8 7.4 13.6 0.69 10.1 7.5 2.8 3 0 0 3 3 2 0 RING-H2 zinc finger domain Brix PF04427.16 001309246.1_21027001_2 - 1.4e-42 145.9 0.0 2.1e-42 145.3 0.0 1.3 1 0 0 1 1 1 1 Brix domain Swi3 PF07962.10 001283066.1_21022001_3 - 8.8e-34 115.2 0.4 1.5e-33 114.4 0.4 1.4 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 zf-RING_9 PF13901.4 001101897.2_06527001_3 - 6.8e-70 235.1 15.1 1.7e-69 233.8 15.1 1.7 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon RUN PF02759.17 001101897.2_06527001_3 - 9.1e-10 38.5 0.5 2.1e-09 37.3 0.5 1.6 1 0 0 1 1 1 1 RUN domain Spectrin PF00435.19 001163869.1_21026001_3 - 1.3e-73 244.1 23.2 3.5e-24 85.2 8.7 4.3 4 0 0 4 4 4 4 Spectrin repeat CH PF00307.29 001163869.1_21026001_3 - 8.7e-56 186.7 0.1 6.2e-29 100.2 0.0 2.9 2 0 0 2 2 2 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.8 001163869.1_21026001_3 - 4.8e-26 90.5 0.0 1.6e-25 88.8 0.0 2.0 1 0 0 1 1 1 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.6 001163869.1_21026001_3 - 3.2e-10 39.6 0.0 7.6e-09 35.2 0.0 2.5 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_1 PF00036.30 001163869.1_21026001_3 - 9.2e-07 27.9 0.2 0.0097 15.3 0.1 3.3 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.4 001163869.1_21026001_3 - 7.5e-06 26.2 0.1 5.2e-05 23.5 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.4 001163869.1_21026001_3 - 0.00012 21.5 0.0 0.024 14.4 0.0 3.6 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.4 001163869.1_21026001_3 - 0.0028 17.2 0.6 0.3 10.8 0.3 3.6 3 1 1 4 4 4 1 EF-hand domain pair BLOC1_2 PF10046.7 001163869.1_21026001_3 - 0.44 10.7 6.0 4.4 7.5 0.1 3.7 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Kelch_6 PF13964.4 001309228.1_21029001_1 - 2e-35 119.7 7.1 2.3e-06 27.6 0.0 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.23 001309228.1_21029001_1 - 2.4e-34 116.5 9.3 5.3e-08 32.2 0.0 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.4 001309228.1_21029001_1 - 6.7e-30 102.7 15.4 1.2e-09 37.8 0.0 6.3 5 1 2 7 7 7 4 Galactose oxidase, central domain Kelch_5 PF13854.4 001309228.1_21029001_1 - 3.7e-27 93.7 6.8 7.1e-05 22.5 0.1 6.9 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.4 001309228.1_21029001_1 - 1.9e-24 85.3 15.6 1.7e-06 28.0 0.0 7.3 8 0 0 8 8 8 4 Galactose oxidase, central domain Kelch_2 PF07646.13 001309228.1_21029001_1 - 2e-22 78.1 7.9 0.0001 22.0 0.1 6.7 6 0 0 6 6 6 5 Kelch motif CCDC66 PF15236.4 001309235.1_21029001_3 - 9.1e-08 32.0 40.3 9.1e-08 32.0 40.3 6.7 7 0 0 7 7 7 2 Coiled-coil domain-containing protein 66 CEP63 PF17045.3 001308416.1_21025001_1 - 6.9e-106 353.9 52.0 6.9e-106 353.9 52.0 3.5 3 1 1 4 4 4 1 Centrosomal protein of 63 kDa Reo_sigmaC PF04582.10 001308416.1_21025001_1 - 0.95 8.7 25.7 0.027 13.7 4.6 4.4 2 2 3 5 5 5 0 Reovirus sigma C capsid protein Histone_H2A_C PF16211.3 001355022.1_06522001_1 - 1.4e-20 72.6 1.2 2.3e-20 71.9 1.2 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.22 001355022.1_06522001_1 - 9.1e-17 61.6 0.0 1.3e-16 61.1 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 001355022.1_06522001_1 - 3.8e-05 23.8 0.0 8e-05 22.7 0.0 1.5 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone V1R PF03402.12 001167532.1_21022001_1 - 1.3e-32 113.3 11.6 1.3e-32 113.3 11.6 1.4 2 0 0 2 2 2 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001167532.1_21022001_1 - 7.7e-07 28.4 17.9 1.1e-06 27.9 17.9 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001167532.1_21022001_1 - 0.00049 19.3 13.9 0.00079 18.6 13.9 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) HemY_N PF07219.11 001167532.1_21022001_1 - 0.14 12.3 0.2 0.41 10.7 0.2 1.8 1 0 0 1 1 1 0 HemY protein N-terminus Defensin_propep PF00879.16 001166082.1_21021001_1 - 1.8e-22 79.2 1.8 2.4e-22 78.9 1.8 1.2 1 0 0 1 1 1 1 Defensin propeptide CDRN PF05174.10 001166082.1_21021001_2 - 0.13 11.9 0.3 0.29 10.7 0.0 1.8 2 0 0 2 2 2 0 Cysteine-rich D. radiodurans N terminus IP_trans PF02121.16 001163878.1_21024001_3 - 7.9e-111 369.4 4.3 9.6e-111 369.1 4.3 1.1 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein WD40 PF00400.30 001257086.1_21023001_1 - 7.6e-07 29.6 0.6 0.017 15.8 1.0 4.4 4 0 0 4 4 4 2 WD domain, G-beta repeat Sugar_tr PF00083.22 001081879.2_21024001_1 - 6.5e-161 536.1 22.5 7.6e-161 535.8 22.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001081879.2_21024001_1 - 5e-21 74.9 55.3 3e-19 69.0 29.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily LRR_2 PF07723.11 001081879.2_21024001_1 - 0.16 12.6 0.5 0.41 11.3 0.5 1.8 1 0 0 1 1 1 0 Leucine Rich Repeat Phage_holin_2_3 PF16080.3 001081879.2_21024001_1 - 1.8 8.2 5.6 0.28 10.9 0.4 2.4 2 0 0 2 2 2 0 Bacteriophage holin family HP1 7tm_1 PF00001.19 001257151.1_21025001_2 - 8.2e-44 149.7 15.8 1.4e-43 149.0 15.8 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3704 PF12488.6 001257151.1_21025001_3 - 0.25 10.9 1.8 0.64 9.6 1.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3704) Mitoc_L55 PF09776.7 001270956.1_21022001_2 - 0.38 10.4 0.8 0.6 9.7 0.8 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L55 COX4 PF02936.12 001270956.1_21022001_3 - 4.7e-51 172.3 3.3 6.2e-51 171.9 3.3 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV RnaseA PF00074.18 001163987.1_21022001_1 - 1.5e-20 73.8 4.1 1.9e-20 73.4 4.1 1.1 1 0 0 1 1 1 1 Pancreatic ribonuclease 7tm_1 PF00001.19 001257126.1_21023001_2 - 8e-47 159.6 11.8 9.8e-47 159.3 11.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001257126.1_21023001_2 - 1.9e-11 43.7 19.1 1.7e-08 34.0 13.7 2.5 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.7 001257126.1_21023001_2 - 0.00039 19.7 12.0 0.00039 19.7 12.0 2.4 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srx PF10328.7 001257126.1_21023001_2 - 0.38 9.9 24.3 0.0071 15.6 16.2 2.0 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx Filament PF00038.19 001346185.1_21024001_1 - 1.2e-111 373.1 32.4 1.4e-111 372.9 32.4 1.1 1 0 0 1 1 1 1 Intermediate filament protein Lzipper-MIP1 PF14389.4 001346185.1_21024001_1 - 0.0097 16.0 3.7 0.0097 16.0 3.7 4.0 3 2 1 4 4 4 1 Leucine-zipper of ternary complex factor MIP1 Baculo_PEP_C PF04513.10 001346185.1_21024001_1 - 0.027 14.4 15.3 0.35 10.8 8.1 3.4 2 1 2 4 4 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.10 001346185.1_21024001_1 - 0.53 10.1 14.4 4.2 7.3 2.0 4.2 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) DUF3373 PF11853.6 001346185.1_21024001_1 - 0.76 8.3 4.1 3.3 6.2 4.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3373) TPR_MLP1_2 PF07926.10 001346185.1_21024001_1 - 0.95 9.4 31.4 0.38 10.7 10.1 3.8 3 2 0 3 3 3 0 TPR/MLP1/MLP2-like protein Uso1_p115_C PF04871.11 001346185.1_21024001_1 - 1.8 8.8 18.8 0.55 10.5 4.0 3.0 2 2 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Nsp1_C PF05064.11 001346185.1_21024001_1 - 3.5 7.3 16.6 0.069 12.8 5.7 2.8 2 2 0 2 2 2 0 Nsp1-like C-terminal region Bacillus_HBL PF05791.9 001346185.1_21024001_1 - 3.5 7.2 8.9 0.48 10.0 2.1 2.7 1 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) DivIC PF04977.13 001346185.1_21024001_1 - 4.1 7.1 21.3 1.5 8.5 0.1 5.3 4 1 0 5 5 5 0 Septum formation initiator Jnk-SapK_ap_N PF09744.7 001346185.1_21024001_1 - 4.3 7.4 28.6 1.7 8.7 8.5 3.6 2 2 2 4 4 4 0 JNK_SAPK-associated protein-1 Phage_GP20 PF06810.9 001346185.1_21024001_1 - 5.7 6.6 15.1 0.76 9.4 0.9 3.4 2 1 2 4 4 4 0 Phage minor structural protein GP20 Reo_sigmaC PF04582.10 001346185.1_21024001_1 - 6.2 6.0 8.3 4.8 6.3 4.7 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein FliD_C PF07195.10 001346185.1_21024001_1 - 8.5 5.6 8.0 17 4.6 7.0 2.1 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus ERM PF00769.17 001346185.1_21024001_1 - 9.7 5.8 19.6 0.36 10.5 6.3 2.2 1 1 1 2 2 2 0 Ezrin/radixin/moesin family AAA PF00004.27 001206489.2_06529001_3 - 1e-07 32.3 0.3 1e-05 25.8 0.0 3.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 001206489.2_06529001_3 - 0.00013 22.1 0.3 0.0029 17.7 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_14 PF13173.4 001206489.2_06529001_3 - 0.01 15.8 0.2 0.62 10.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain Ribosomal_S19e PF01090.17 001206489.2_06529001_3 - 0.011 15.4 0.0 0.043 13.4 0.0 2.0 1 0 0 1 1 1 0 Ribosomal protein S19e AAA_16 PF13191.4 001206489.2_06529001_3 - 0.016 15.4 0.0 0.06 13.6 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain NTPase_1 PF03266.13 001206489.2_06529001_3 - 0.021 14.6 0.1 0.097 12.4 0.0 2.2 2 0 0 2 2 2 0 NTPase T2SSE PF00437.18 001206489.2_06529001_3 - 0.035 13.0 0.0 0.075 11.9 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_18 PF13238.4 001206489.2_06529001_3 - 0.66 10.4 4.1 1.8 8.9 0.0 3.4 3 0 0 3 3 3 0 AAA domain Fcf2 PF08698.9 001309173.1_21026001_3 - 5.1e-40 135.7 0.4 3.5e-39 133.0 0.4 2.6 1 0 0 1 1 1 1 Fcf2 pre-rRNA processing DUF4576 PF15144.4 001309173.1_21026001_3 - 1 9.2 3.6 20 5.0 2.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4576) Adeno_E3_CR2 PF02439.13 001256954.1_21021001_1 - 0.029 14.0 0.3 0.042 13.5 0.3 1.2 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Syndecan PF01034.18 001256954.1_21021001_1 - 2.2 8.2 3.5 7.9 6.3 2.8 1.9 2 0 0 2 2 2 0 Syndecan domain Reprolysin PF01421.17 001192818.3_06529001_1 - 3.9e-70 235.7 0.0 8e-70 234.7 0.0 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.10 001192818.3_06529001_1 - 4e-32 110.9 5.1 4e-32 110.9 5.1 2.9 3 0 0 3 3 3 1 ADAM cysteine-rich Pep_M12B_propep PF01562.17 001192818.3_06529001_1 - 1.2e-29 103.2 0.4 2e-29 102.5 0.4 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.4 001192818.3_06529001_1 - 6.2e-20 72.1 0.1 1.3e-19 71.0 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Disintegrin PF00200.21 001192818.3_06529001_1 - 8.8e-20 71.2 27.6 8.8e-20 71.2 27.6 4.8 5 1 0 5 5 5 1 Disintegrin Reprolysin_3 PF13582.4 001192818.3_06529001_1 - 6.2e-16 58.9 0.0 1e-15 58.2 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 001192818.3_06529001_1 - 4.3e-10 39.4 0.0 7.5e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.4 001192818.3_06529001_1 - 2.8e-09 37.0 0.1 5.1e-09 36.2 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.22 001192818.3_06529001_1 - 0.05 13.3 0.0 0.083 12.6 0.0 1.2 1 0 0 1 1 1 0 Matrixin zf-H2C2_2 PF13465.4 001024491.4_06525001_3 - 5.5e-24 83.4 30.8 2.2e-07 30.9 0.6 6.3 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2 PF00096.24 001024491.4_06525001_3 - 4.6e-21 73.9 29.2 3.3e-05 24.0 0.1 6.5 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001024491.4_06525001_3 - 1.1e-12 47.5 30.5 0.0057 17.2 4.4 6.6 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2HC_2 PF13913.4 001024491.4_06525001_3 - 0.00031 20.4 4.3 0.44 10.4 0.0 4.6 5 0 0 5 5 5 2 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.3 001024491.4_06525001_3 - 0.00046 19.8 15.1 0.81 9.4 2.1 4.1 4 0 0 4 4 4 3 zinc-finger C2H2-type zf-C2H2_8 PF15909.3 001024491.4_06525001_3 - 0.0011 19.1 8.5 0.0035 17.5 1.6 2.7 1 1 1 2 2 2 1 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.3 001024491.4_06525001_3 - 0.0038 17.3 7.8 3.2 7.8 0.1 4.0 1 1 2 4 4 4 2 Aberrant zinc-finger zf-C2H2_jaz PF12171.6 001024491.4_06525001_3 - 0.23 11.7 8.1 4.3 7.6 0.0 4.3 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 001024491.4_06525001_3 - 2.4 8.5 17.2 0.95 9.8 0.1 4.7 5 0 0 5 5 5 0 Zinc-finger of C2H2 type Myf5 PF12232.6 001302119.1_21023001_1 - 2.5e-26 92.1 12.1 2.5e-26 92.1 12.1 2.4 2 0 0 2 2 2 1 Myogenic determination factor 5 Basic PF01586.14 001302119.1_21023001_1 - 2.4e-22 79.8 1.0 7.9e-22 78.1 1.0 1.9 1 0 0 1 1 1 1 Myogenic Basic domain HLH PF00010.24 001302119.1_21023001_1 - 4.4e-15 55.2 4.5 1e-14 54.1 4.5 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Auxin_repressed PF05564.10 001302119.1_21023001_1 - 2.7 8.6 5.3 2.1 8.9 0.3 2.4 1 1 1 2 2 2 0 Dormancy/auxin associated protein Filament PF00038.19 001163861.1_21023001_3 - 5.4e-111 371.0 51.1 6.5e-111 370.7 51.1 1.1 1 0 0 1 1 1 1 Intermediate filament protein Filament_head PF04732.12 001163861.1_21023001_3 - 1.1e-06 29.3 1.4 3e-06 27.9 0.4 2.2 2 0 0 2 2 2 1 Intermediate filament head (DNA binding) region Spc7 PF08317.9 001163861.1_21023001_3 - 0.011 14.6 46.0 0.047 12.4 12.1 3.1 1 1 2 3 3 3 0 Spc7 kinetochore protein Reo_sigmaC PF04582.10 001163861.1_21023001_3 - 0.011 15.0 6.7 0.25 10.6 0.8 2.8 1 1 1 3 3 3 0 Reovirus sigma C capsid protein DUF1664 PF07889.10 001163861.1_21023001_3 - 0.017 15.0 14.4 0.1 12.4 1.2 3.5 3 1 0 4 4 4 0 Protein of unknown function (DUF1664) Jnk-SapK_ap_N PF09744.7 001163861.1_21023001_3 - 0.033 14.3 48.9 0.036 14.1 17.7 3.5 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 DUF4407 PF14362.4 001163861.1_21023001_3 - 0.13 11.4 35.9 0.11 11.7 16.6 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Golgin_A5 PF09787.7 001163861.1_21023001_3 - 0.63 9.3 41.9 1.1 8.6 20.2 2.5 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF573 PF04504.12 001163861.1_21023001_3 - 0.64 10.6 3.7 0.92 10.1 0.4 2.9 2 2 1 3 3 3 0 Protein of unknown function, DUF573 TPR_MLP1_2 PF07926.10 001163861.1_21023001_3 - 1.3 9.0 51.0 2.9 7.8 17.9 3.8 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.7 001163861.1_21023001_3 - 1.5 8.7 43.8 0.67 9.8 10.5 3.7 1 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fib_alpha PF08702.8 001163861.1_21023001_3 - 1.6 8.8 21.9 0.55 10.3 6.0 3.3 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family ApoO PF09769.7 001163861.1_21023001_3 - 2.2 8.1 9.5 4.4 7.1 0.7 4.0 1 1 3 4 4 4 0 Apolipoprotein O WD40_alt PF14077.4 001163861.1_21023001_3 - 2.7 7.8 7.2 1.6 8.6 2.8 2.9 2 1 0 2 2 2 0 Alternative WD40 repeat motif GAS PF13851.4 001163861.1_21023001_3 - 2.7 7.2 45.0 0.31 10.3 13.4 3.6 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF3584 PF12128.6 001163861.1_21023001_3 - 3.3 5.0 43.6 0.26 8.6 25.7 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) APG6 PF04111.10 001163861.1_21023001_3 - 8.3 5.6 48.2 0.95 8.7 6.4 3.1 1 1 2 3 3 3 0 Autophagy protein Apg6 EMP24_GP25L PF01105.22 001202561.1_21023001_2 - 7.6e-50 169.2 0.3 9.1e-50 169.0 0.3 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF2042 PF09743.7 001309224.1_21026001_1 - 3e-115 384.4 0.5 3e-115 384.4 0.5 1.6 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2042) DUF682 PF05081.10 001309224.1_21026001_1 - 0.029 14.0 0.2 0.07 12.7 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF682) IL31 PF15209.4 001309224.1_21026001_1 - 0.057 13.1 0.7 0.13 11.9 0.0 2.0 2 0 0 2 2 2 0 Interleukin 31 Tn7_Tnp_TnsA_C PF08721.9 001309224.1_21026001_1 - 0.4 11.2 6.4 0.89 10.1 0.0 4.4 5 0 0 5 5 5 0 TnsA endonuclease C terminal DDE_Tnp_1_3 PF13612.4 001309224.1_21026001_1 - 2.1 8.2 7.3 0.47 10.3 0.5 3.2 3 1 1 4 4 4 0 Transposase DDE domain RCC1 PF00415.16 001205211.1_21025001_3 - 2.9e-85 280.6 18.9 3.9e-14 52.9 0.0 7.6 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 001205211.1_21025001_3 - 1.1e-28 98.3 33.7 1.3e-08 34.3 0.3 7.7 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat Peptidase_C25_C PF03785.12 001205211.1_21025001_3 - 0.0079 15.9 0.0 2.2 8.1 0.0 3.1 3 0 0 3 3 3 1 Peptidase family C25, C terminal ig-like domain SUKH-3 PF14433.4 001205211.1_21025001_3 - 0.032 14.6 2.4 36 4.7 0.0 4.7 5 0 0 5 5 5 0 SUKH-3 immunity protein DUF4681 PF15732.3 001301249.1_21029001_2 - 0.43 10.7 2.6 0.51 10.5 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4681) His_Phos_1 PF00300.20 001301264.1_21029001_3 - 2.2e-30 105.7 0.0 3.1e-28 98.7 0.0 2.2 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) zf-C4 PF00105.16 001242553.1_21024001_1 - 3.7e-28 97.6 16.3 7.3e-28 96.7 16.3 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001242553.1_21024001_1 - 4.2e-14 52.5 0.0 1.2e-13 51.0 0.0 1.7 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor UQ_con PF00179.24 001242449.1_21026001_1 - 2.1e-52 176.4 0.0 2.9e-52 175.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.20 001242449.1_21026001_1 - 0.03 14.5 0.0 0.052 13.7 0.0 1.3 1 0 0 1 1 1 0 RWD domain Homeobox PF00046.27 001192128.1_06522001_1 - 3.5e-19 68.2 2.8 4.2e-19 68.0 1.4 1.9 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.9 001192128.1_06522001_1 - 0.019 14.8 0.0 0.045 13.5 0.0 1.7 1 0 0 1 1 1 0 Homeobox KN domain Ank_2 PF12796.5 001257147.1_21023001_1 - 1.5e-22 79.8 0.9 1.9e-13 50.7 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001257147.1_21023001_1 - 1.6e-15 57.1 0.7 2.8e-05 24.4 0.0 3.2 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.28 001257147.1_21023001_1 - 3.1e-14 52.6 2.3 2.4e-05 24.4 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.4 001257147.1_21023001_1 - 2.3e-13 48.8 0.4 0.0019 18.4 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.4 001257147.1_21023001_1 - 7.6e-09 35.6 6.5 1.8e-06 28.0 1.2 3.4 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Glycos_transf_N PF04413.14 001257147.1_21023001_1 - 0.014 15.0 0.0 0.027 14.1 0.0 1.4 1 1 0 1 1 1 0 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) FMN_dh PF01070.16 001257147.1_21023001_1 - 0.039 12.8 0.0 0.055 12.4 0.0 1.1 1 0 0 1 1 1 0 FMN-dependent dehydrogenase YjcZ PF13990.4 001257147.1_21023001_1 - 0.21 10.8 0.0 0.31 10.3 0.0 1.2 1 0 0 1 1 1 0 YjcZ-like protein Granin PF01271.15 001257121.1_21024001_1 - 2.5e-215 716.7 39.3 2.9e-215 716.5 39.3 1.0 1 0 0 1 1 1 1 Granin (chromogranin or secretogranin) Ribosomal_L21e PF01157.16 001191412.1_06524001_1 - 2.9e-51 171.2 8.3 5.2e-51 170.4 8.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L21e SRP19 PF01922.15 001166393.1_26228001_2 - 0.34 11.7 2.0 0.98 10.3 2.0 1.8 1 0 0 1 1 1 0 SRP19 protein Filament PF00038.19 001346211.1_21024001_1 - 1e-99 333.9 30.1 1.2e-99 333.7 30.1 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001346211.1_21024001_1 - 2.4e-11 43.9 8.5 2.4e-11 43.9 8.5 2.2 2 1 0 2 2 1 1 Keratin type II head TPR_MLP1_2 PF07926.10 001346211.1_21024001_1 - 7.6e-07 29.1 26.9 1.9e-05 24.6 1.4 3.3 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein Spc7 PF08317.9 001346211.1_21024001_1 - 0.00057 18.7 22.5 0.053 12.3 11.3 2.9 1 1 2 3 3 3 2 Spc7 kinetochore protein Tropomyosin_1 PF12718.5 001346211.1_21024001_1 - 0.0065 16.5 9.9 0.0065 16.5 9.9 3.5 3 1 0 3 3 3 1 Tropomyosin like DUF4924 PF16271.3 001346211.1_21024001_1 - 0.01 15.7 0.8 0.019 14.9 0.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4924) BRE1 PF08647.9 001346211.1_21024001_1 - 0.022 14.7 1.1 0.022 14.7 1.1 3.3 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase DUF1635 PF07795.9 001346211.1_21024001_1 - 0.14 11.9 4.5 0.28 11.0 4.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) DUF3355 PF11835.6 001346211.1_21024001_1 - 0.18 11.4 0.8 0.44 10.1 0.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3355) DUF641 PF04859.10 001346211.1_21024001_1 - 0.39 10.9 9.5 2.3 8.4 2.0 2.6 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Alanine_zipper PF11839.6 001346211.1_21024001_1 - 0.42 10.8 10.2 0.065 13.4 6.1 1.8 2 0 0 2 2 1 0 Alanine-zipper, major outer membrane lipoprotein Reo_sigmaC PF04582.10 001346211.1_21024001_1 - 0.49 9.6 2.6 1.5 8.0 1.7 1.9 1 1 2 3 3 3 0 Reovirus sigma C capsid protein Spc42p PF11544.6 001346211.1_21024001_1 - 0.55 10.1 3.2 0.28 11.1 0.3 2.0 2 0 0 2 2 2 0 Spindle pole body component Spc42p DUF1664 PF07889.10 001346211.1_21024001_1 - 0.88 9.4 6.2 5.7 6.8 1.5 3.3 1 1 2 4 4 4 0 Protein of unknown function (DUF1664) MRFAP1 PF15155.4 001346211.1_21024001_1 - 1.3 9.4 8.2 0.92 9.9 3.5 2.6 2 1 0 3 3 3 0 MORF4 family-associated protein1 TSNAXIP1_N PF15739.3 001346211.1_21024001_1 - 1.8 8.9 15.1 0.04 14.2 2.4 3.5 2 2 2 4 4 4 0 Translin-associated factor X-interacting N-terminus DUF1759 PF03564.13 001346211.1_21024001_1 - 2 8.2 5.7 7.1 6.4 0.5 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1759) Virulence_fact PF13769.4 001346211.1_21024001_1 - 2 8.4 5.1 2.2 8.3 0.1 3.2 3 0 0 3 3 3 0 Virulence factor Nsp1_C PF05064.11 001346211.1_21024001_1 - 3.1 7.5 7.2 4 7.1 1.9 2.7 2 0 0 2 2 2 0 Nsp1-like C-terminal region FlaC_arch PF05377.9 001346211.1_21024001_1 - 4.2 7.7 6.7 9 6.6 0.6 3.9 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) DASH_Duo1 PF08651.8 001346211.1_21024001_1 - 4.2 7.1 6.7 2.5 7.8 2.2 2.9 4 0 0 4 4 4 0 DASH complex subunit Duo1 DUF972 PF06156.11 001346211.1_21024001_1 - 4.6 7.8 20.1 9.1 6.8 3.0 4.0 2 2 2 4 4 4 0 Protein of unknown function (DUF972) SPATA1_C PF15743.3 001346211.1_21024001_1 - 5.5 6.9 16.1 2.8 7.9 0.1 3.0 3 1 0 3 3 3 0 Spermatogenesis-associated C-terminus DUF2205 PF10224.7 001346211.1_21024001_1 - 5.8 6.8 7.9 2.2 8.2 0.6 3.2 3 0 0 3 3 3 0 Predicted coiled-coil protein (DUF2205) MCC-bdg_PDZ PF10506.7 001346211.1_21024001_1 - 7.3 6.6 11.4 1.3 9.0 3.2 3.5 2 2 1 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome 7tm_1 PF00001.19 001257179.1_21023001_1 - 1.1e-37 129.6 11.7 1.4e-37 129.3 11.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001257179.1_21023001_1 - 2.1e-08 34.1 7.4 0.00029 20.5 1.6 2.2 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001257179.1_21023001_1 - 3.6e-08 33.0 6.8 8.8e-08 31.7 6.8 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001257179.1_21023001_1 - 0.0059 15.8 2.3 0.0059 15.8 2.3 1.8 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Oxidored_q4 PF00507.17 001257179.1_21023001_1 - 0.3 11.1 3.6 6.7 6.8 0.4 2.6 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 Exo84_C PF16528.3 001256924.1_21025001_3 - 4.3e-56 189.9 0.2 1.5e-55 188.1 0.0 1.9 2 0 0 2 2 2 1 Exocyst component 84 C-terminal Vps51 PF08700.9 001256924.1_21025001_3 - 1.4e-18 66.6 2.6 3.9e-18 65.2 2.6 1.8 1 0 0 1 1 1 1 Vps51/Vps67 PH PF00169.27 001256924.1_21025001_3 - 0.026 14.9 0.0 0.074 13.4 0.0 1.8 2 0 0 2 2 2 0 PH domain Dor1 PF04124.10 001256924.1_21025001_3 - 0.029 12.9 8.3 0.38 9.2 0.0 2.8 3 0 0 3 3 3 0 Dor1-like family UPF0242 PF06785.9 001256924.1_21025001_3 - 0.057 12.0 0.0 0.057 12.0 0.0 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) BK_channel_a PF03493.16 001163249.1_06527001_1 - 9.3e-29 99.4 0.0 2.3e-28 98.2 0.0 1.7 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Ion_trans PF00520.29 001163249.1_06527001_1 - 1.5e-16 60.3 15.5 1.5e-16 60.3 15.5 2.7 1 1 1 2 2 2 1 Ion transport protein Ion_trans_2 PF07885.14 001163249.1_06527001_1 - 1.3e-13 50.6 3.0 1.3e-13 50.6 3.0 3.7 4 0 0 4 4 4 1 Ion channel Lig_chan PF00060.24 001163249.1_06527001_1 - 8.3e-05 22.3 5.1 0.00019 21.1 0.3 3.0 3 0 0 3 3 3 1 Ligand-gated ion channel TrkA_N PF02254.16 001163249.1_06527001_1 - 0.032 14.4 0.0 0.11 12.6 0.0 1.8 2 0 0 2 2 2 0 TrkA-N domain Cupin_8 PF13621.4 001204232.1_21022001_1 - 3e-78 263.0 0.0 3.6e-78 262.7 0.0 1.0 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.20 001204232.1_21022001_1 - 0.0028 17.9 0.0 0.0061 16.9 0.0 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase FbpA PF05833.9 001205505.2_06528001_1 - 9.1e-39 133.3 15.5 2.6e-38 131.8 15.6 1.7 1 1 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) DUF3441 PF11923.6 001205505.2_06528001_1 - 1.3e-29 102.3 0.1 1.3e-29 102.3 0.1 4.1 4 1 0 4 4 4 1 Domain of unknown function (DUF3441) DUF814 PF05670.11 001205505.2_06528001_1 - 7.8e-24 83.4 0.0 2e-23 82.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF814) Ephrin PF00812.15 001114942.1_21023001_1 - 8.8e-43 145.5 0.0 2e-42 144.3 0.0 1.5 2 0 0 2 2 2 1 Ephrin EAF PF09816.7 001309227.1_21023001_1 - 4.3e-21 75.0 0.0 1.6e-20 73.2 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase II transcription elongation factor AF-4 PF05110.11 001309227.1_21023001_1 - 0.62 8.0 21.7 1 7.3 21.7 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Filament PF00038.19 001346213.1_21026001_2 - 6.6e-99 331.3 23.1 7.9e-99 331.0 23.1 1.1 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001346213.1_21026001_2 - 2.6e-11 43.8 12.1 8.6e-10 38.9 0.1 2.8 2 1 1 3 3 3 2 Keratin type II head TPR_MLP1_2 PF07926.10 001346213.1_21026001_2 - 0.00071 19.5 20.6 0.0019 18.1 0.1 3.0 3 0 0 3 3 3 2 TPR/MLP1/MLP2-like protein ComX PF05952.10 001346213.1_21026001_2 - 0.088 12.9 0.7 0.7 10.0 0.1 2.2 2 0 0 2 2 2 0 Bacillus competence pheromone ComX CHDCT2 PF08074.9 001346213.1_21026001_2 - 0.14 12.2 3.8 0.54 10.3 0.2 2.3 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain BRE1 PF08647.9 001346213.1_21026001_2 - 0.64 10.0 12.5 0.054 13.4 0.8 3.2 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase Jnk-SapK_ap_N PF09744.7 001346213.1_21026001_2 - 0.85 9.7 21.5 0.23 11.6 1.2 3.0 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 HIP1_clath_bdg PF16515.3 001346213.1_21026001_2 - 0.95 10.0 10.7 0.27 11.7 5.9 2.4 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Spc24 PF08286.9 001346213.1_21026001_2 - 1.6 8.9 6.1 1.1 9.4 1.2 2.9 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 Tropomyosin_1 PF12718.5 001346213.1_21026001_2 - 3.3 7.7 20.4 0.46 10.5 8.0 3.2 3 1 0 3 3 3 0 Tropomyosin like ADIP PF11559.6 001346213.1_21026001_2 - 6.3 6.7 15.2 0.29 11.1 6.6 2.4 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4472 PF14739.4 001346213.1_21026001_2 - 7.8 7.1 10.5 37 5.0 5.3 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4472) PX PF00787.22 001309327.1_21029001_2 - 4.7e-22 78.0 5.9 4.7e-22 78.0 5.9 2.3 3 0 0 3 3 3 1 PX domain PLDc_2 PF13091.4 001309327.1_21029001_2 - 1.1e-15 57.5 0.2 4.8e-10 39.3 0.1 2.8 2 1 0 2 2 2 2 PLD-like domain PLDc PF00614.20 001309327.1_21029001_2 - 1.1e-14 53.8 1.1 1.5e-07 31.1 0.1 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif PH PF00169.27 001309327.1_21029001_2 - 3.8e-08 33.6 0.0 8.6e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 PH domain CALM_bind PF16025.3 001309278.1_21029001_3 - 5.2e-23 81.1 16.0 3.3e-19 68.9 1.6 3.5 3 0 0 3 3 3 2 Calcium-dependent calmodulin binding p450 PF00067.20 001190939.1_21024001_1 - 5.8e-128 427.4 0.7 6.6e-128 427.2 0.7 1.0 1 0 0 1 1 1 1 Cytochrome P450 SapB_2 PF03489.15 001163876.1_21024001_1 - 1.5e-18 66.4 12.1 2.2e-10 40.4 0.9 4.4 4 0 0 4 4 4 3 Saposin-like type B, region 2 SapA PF02199.13 001163876.1_21024001_1 - 7.5e-13 48.3 4.0 7.5e-13 48.3 4.0 2.7 2 0 0 2 2 2 1 Saposin A-type domain SapB_1 PF05184.13 001163876.1_21024001_1 - 3.2e-10 39.7 3.7 4e-06 26.6 0.9 4.0 3 0 0 3 3 3 3 Saposin-like type B, region 1 TilS PF09179.9 001163876.1_21024001_1 - 0.033 14.6 1.9 0.09 13.2 1.9 1.7 1 0 0 1 1 1 0 TilS substrate binding domain ANP PF00212.16 001082501.2_21022001_1 - 4.4e-11 42.6 3.0 7.8e-11 41.8 3.0 1.4 1 0 0 1 1 1 1 Atrial natriuretic peptide Fungal_KA1 PF16797.3 001309277.1_21024001_3 - 0.13 11.9 0.6 0.3 10.7 0.3 1.7 2 0 0 2 2 2 0 Fungal kinase associated-1 domain SOBP PF15279.4 001256928.1_21024001_1 - 1.3e-08 35.7 35.9 1.3e-08 35.7 35.9 3.0 2 1 0 2 2 2 1 Sine oculis-binding protein HERV-K_env_2 PF13804.4 001256928.1_21024001_1 - 0.048 13.3 0.1 0.086 12.5 0.1 1.4 1 0 0 1 1 1 0 Retro-transcribing viruses envelope glycoprotein IL8 PF00048.18 001130078.1_21021001_1 - 7.5e-17 61.1 0.3 1.9e-16 59.8 0.3 1.7 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Rtf2 PF04641.10 001130078.1_21021001_1 - 0.013 14.7 6.6 0.013 14.7 6.6 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Transferrin PF00405.15 001163974.1_21025001_1 - 6.1e-261 863.6 6.6 5.4e-174 577.9 0.1 2.0 2 0 0 2 2 2 2 Transferrin Phosphonate-bd PF12974.5 001163974.1_21025001_1 - 1.5e-10 41.0 0.0 6.9e-05 22.4 0.0 3.2 2 2 1 3 3 3 2 ABC transporter, phosphonate, periplasmic substrate-binding protein PAD PF03068.13 001163822.1_21024001_1 - 9.3e-169 561.3 0.0 1.1e-168 561.0 0.0 1.1 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) PAD_M PF08527.8 001163822.1_21024001_1 - 4.9e-68 227.6 0.0 8.7e-68 226.8 0.0 1.4 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) middle domain PAD_N PF08526.8 001163822.1_21024001_1 - 2e-34 118.2 0.1 3.5e-34 117.4 0.1 1.4 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) N-terminal domain Cu2_monoox_C PF03712.13 001081770.2_21028001_3 - 8e-65 217.0 0.0 1.3e-64 216.4 0.0 1.3 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, C-terminal domain Cu2_monooxygen PF01082.18 001081770.2_21028001_3 - 4.3e-46 156.3 0.0 7.3e-46 155.5 0.0 1.4 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain DOMON PF03351.15 001081770.2_21028001_3 - 1.7e-26 92.7 0.0 2.9e-26 92.0 0.0 1.3 1 0 0 1 1 1 1 DOMON domain Sad1_UNC PF07738.11 001076084.2_06523001_1 - 1.3e-44 151.3 0.0 2.1e-44 150.7 0.0 1.3 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Peptidase_A22B PF04258.11 001046124.2_06524001_3 - 1.2e-102 343.1 7.8 1.5e-102 342.8 7.8 1.1 1 0 0 1 1 1 1 Signal peptide peptidase SPP PF06550.9 001046124.2_06524001_3 - 3e-05 23.5 6.4 5.5e-05 22.6 6.4 1.4 1 0 0 1 1 1 1 Signal-peptide peptidase, presenilin aspartyl protease DUF4345 PF14248.4 001046124.2_06524001_3 - 0.0014 18.4 0.6 0.0014 18.4 0.6 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4345) Presenilin PF01080.15 001046124.2_06524001_3 - 0.01 14.5 5.8 0.0085 14.7 4.5 1.5 1 1 0 1 1 1 0 Presenilin CTP_transf_like PF01467.24 001309407.1_21024001_3 - 1.8e-29 102.6 0.0 3.2e-29 101.8 0.0 1.4 1 1 0 1 1 1 1 Cytidylyltransferase-like An_peroxidase PF03098.13 001163976.1_21024001_1 - 1e-52 179.3 0.0 5.2e-45 153.9 0.0 2.4 1 1 1 2 2 2 2 Animal haem peroxidase EGF PF00008.25 001163976.1_21024001_1 - 0.00014 21.9 10.0 0.00014 21.9 10.0 2.0 2 0 0 2 2 2 1 EGF-like domain zf-H2C2_2 PF13465.4 001309186.1_21028001_1 - 8.9e-59 193.3 85.0 2.6e-08 33.8 1.9 10.4 10 0 0 10 10 9 8 Zinc-finger double domain zf-C2H2 PF00096.24 001309186.1_21028001_1 - 2.1e-38 128.5 90.7 1.8e-05 24.8 0.6 11.1 10 0 0 10 10 10 9 Zinc finger, C2H2 type KRAB PF01352.25 001309186.1_21028001_1 - 3.6e-22 77.6 0.0 7.7e-22 76.6 0.0 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 001309186.1_21028001_1 - 3e-18 64.8 84.0 0.034 14.8 0.6 11.2 10 0 0 10 10 10 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001309186.1_21028001_1 - 1.3e-09 37.6 58.7 0.13 12.1 0.1 9.7 9 0 0 9 9 9 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001309186.1_21028001_1 - 0.00017 21.5 47.3 0.4 10.7 5.5 6.8 3 2 4 7 7 7 3 Zinc ribbon domain SCAN PF02023.15 001309186.1_21028001_1 - 0.0011 18.6 0.0 0.0023 17.6 0.0 1.5 1 0 0 1 1 1 1 SCAN domain zf-C2H2_jaz PF12171.6 001309186.1_21028001_1 - 0.0012 19.0 46.6 0.2 11.9 1.0 9.4 9 0 0 9 9 9 3 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 001309186.1_21028001_1 - 0.026 14.2 0.4 0.026 14.2 0.4 9.1 9 0 0 9 9 8 0 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 001309186.1_21028001_1 - 0.058 14.0 44.7 0.49 11.0 2.3 5.8 2 1 4 6 6 6 0 zinc-ribbon family zf-met PF12874.5 001309186.1_21028001_1 - 0.096 13.0 0.2 0.096 13.0 0.2 9.1 9 0 0 9 9 9 0 Zinc-finger of C2H2 type XPA_N PF01286.16 001309186.1_21028001_1 - 3.8 7.5 37.4 9.8 6.2 0.3 8.1 9 0 0 9 9 9 0 XPA protein N-terminal RasGEF PF00617.17 001301276.1_21029001_3 - 1.4e-49 168.5 0.2 2.5e-49 167.6 0.2 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.18 001301276.1_21029001_3 - 4.2e-12 46.1 0.4 6.2e-11 42.4 0.4 2.6 1 1 0 1 1 1 1 RasGEF N-terminal motif PDZ PF00595.22 001301276.1_21029001_3 - 6.4e-12 45.5 0.0 1.7e-11 44.2 0.0 1.8 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) RA PF00788.21 001301276.1_21029001_3 - 4.3e-11 43.2 0.0 9.2e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain cNMP_binding PF00027.27 001301276.1_21029001_3 - 1.5e-10 40.8 0.0 8.6e-07 28.8 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain PDZ_2 PF13180.4 001301276.1_21029001_3 - 0.0012 19.0 0.0 0.0029 17.8 0.0 1.5 1 0 0 1 1 1 1 PDZ domain 7tm_1 PF00001.19 001081806.2_21026001_1 - 6.6e-17 61.5 12.5 1.1e-16 60.8 12.5 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Serpentine_r_xa PF03383.13 001081806.2_21026001_1 - 0.0043 16.9 0.9 0.0043 16.9 0.9 2.7 2 1 1 3 3 3 1 Caenorhabditis serpentine receptor-like protein, class xa Somatostatin PF03002.13 001204930.1_21021001_1 - 3.3e-09 36.4 8.6 5.3e-09 35.7 8.6 1.3 1 0 0 1 1 1 1 Somatostatin/Cortistatin family CLAMP PF14769.4 001199127.1_21022001_1 - 1.5e-34 118.3 0.4 3.9e-34 116.9 0.4 1.8 2 0 0 2 2 2 1 Flagellar C1a complex subunit C1a-32 EST1_DNA_bind PF10373.7 001193205.2_06529001_1 - 1.6e-55 188.4 5.6 1.6e-55 188.4 5.6 1.8 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.7 001193205.2_06529001_1 - 1.7e-27 96.6 0.3 6.5e-27 94.7 0.3 2.1 1 0 0 1 1 1 1 Telomerase activating protein Est1 zf-AD PF07776.13 001193205.2_06529001_1 - 0.0085 16.2 0.6 0.038 14.1 0.6 2.2 1 1 0 1 1 1 1 Zinc-finger associated domain (zf-AD) TPR_2 PF07719.15 001193205.2_06529001_1 - 0.12 12.4 0.0 0.31 11.1 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.4 001193205.2_06529001_1 - 0.18 11.8 0.1 0.58 10.2 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat bZIP_1 PF00170.19 001192843.1_06525001_3 - 2.6e-12 46.5 7.9 4.1e-12 45.9 7.9 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 001192843.1_06525001_3 - 1.2e-08 34.8 8.1 2.2e-08 33.9 8.1 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 001192843.1_06525001_3 - 0.0005 20.4 7.7 0.00096 19.5 7.7 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor zf-C2H2 PF00096.24 001192843.1_06525001_3 - 0.0031 17.8 1.1 0.0075 16.5 1.1 1.7 1 0 0 1 1 1 1 Zinc finger, C2H2 type Cnn_1N PF07989.9 001192843.1_06525001_3 - 0.048 13.7 1.7 0.082 12.9 1.7 1.3 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 Sec34 PF04136.13 001206537.1_06529001_2 - 5.2e-54 182.0 7.2 5.2e-54 182.0 7.2 3.4 4 0 0 4 4 4 1 Sec34-like family APG6 PF04111.10 001206537.1_06529001_2 - 0.21 10.8 5.7 0.43 9.8 5.7 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 Laminin_I PF06008.12 001206537.1_06529001_2 - 0.38 10.3 5.3 0.13 11.8 1.6 2.0 2 0 0 2 2 2 0 Laminin Domain I Interferon PF00143.17 001114538.1_21022001_1 - 9.8e-68 227.2 0.0 1.1e-67 227.0 0.0 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain PSP PF04046.14 001205690.1_06527001_1 - 4e-17 61.7 0.1 8.2e-17 60.7 0.1 1.6 1 0 0 1 1 1 1 PSP zf-CCHC PF00098.21 001205690.1_06527001_1 - 3.7e-05 23.5 3.3 8.4e-05 22.3 3.3 1.7 1 0 0 1 1 1 1 Zinc knuckle Herpes_BLRF2 PF05812.10 001205690.1_06527001_1 - 0.062 13.3 0.9 0.28 11.2 0.9 2.1 1 1 0 1 1 1 0 Herpesvirus BLRF2 protein DivIC PF04977.13 001205690.1_06527001_1 - 0.11 12.2 0.3 0.36 10.5 0.3 1.9 1 0 0 1 1 1 0 Septum formation initiator TFIIB PF00382.17 001309309.1_21023001_1 - 4.8e-50 167.4 3.5 2.4e-24 85.1 0.2 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.10 001309309.1_21023001_1 - 3.4e-14 51.9 0.2 6.4e-14 51.1 0.2 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.21 001309309.1_21023001_1 - 1.3e-07 31.3 0.1 1.2e-05 25.0 0.0 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.17 001309309.1_21023001_1 - 0.005 16.8 0.0 0.24 11.3 0.0 2.3 2 0 0 2 2 2 1 Cyclin, C-terminal domain RB_B PF01857.18 001309309.1_21023001_1 - 0.0072 16.2 0.1 0.016 15.1 0.1 1.5 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain Sigma70_r4 PF04545.14 001309309.1_21023001_1 - 0.024 14.0 0.0 0.16 11.4 0.0 2.1 2 0 0 2 2 2 0 Sigma-70, region 4 Mo25 PF08569.9 001309165.1_21027001_2 - 8.3e-137 455.8 12.2 1.1e-136 455.4 12.2 1.1 1 0 0 1 1 1 1 Mo25-like Cys_knot PF00007.20 001081815.2_21021001_3 - 5.1e-34 116.6 16.3 7.3e-34 116.1 16.3 1.2 1 0 0 1 1 1 1 Cystine-knot domain Gal-3-0_sulfotr PF06990.9 001346076.1_21025001_1 - 0.32 9.7 13.5 0.54 8.9 13.5 1.3 1 0 0 1 1 1 0 Galactose-3-O-sulfotransferase zf-C2H2 PF00096.24 001346076.1_21025001_1 - 3.3 8.2 5.8 4 7.9 0.2 3.0 2 0 0 2 2 2 0 Zinc finger, C2H2 type Filament PF00038.19 001346076.1_21025001_2 - 3.3e-115 384.8 38.0 4e-115 384.6 38.0 1.0 1 0 0 1 1 1 1 Intermediate filament protein SPATA1_C PF15743.3 001346076.1_21025001_2 - 0.018 15.0 0.6 0.018 15.0 0.6 3.6 1 1 0 3 3 3 0 Spermatogenesis-associated C-terminus TPR_MLP1_2 PF07926.10 001346076.1_21025001_2 - 0.13 12.1 37.4 0.029 14.3 4.9 3.6 2 2 1 3 3 3 0 TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N PF09744.7 001346076.1_21025001_2 - 0.32 11.1 33.4 0.74 9.9 10.8 3.8 1 1 3 4 4 4 0 JNK_SAPK-associated protein-1 DUF4407 PF14362.4 001346076.1_21025001_2 - 7.7 5.6 22.4 0.86 8.8 4.0 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) WXG100 PF06013.10 001346076.1_21025001_2 - 8.8 6.5 10.7 1.7 8.8 1.3 3.3 3 0 0 3 3 3 0 Proteins of 100 residues with WXG V1R PF03402.12 001166863.1_21023001_1 - 1.7e-26 93.3 17.5 2.6e-26 92.7 17.5 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166863.1_21023001_1 - 2.1e-08 33.5 23.3 3e-08 33.0 23.3 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001166863.1_21023001_1 - 5.6e-05 22.4 15.1 7.2e-05 22.0 15.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) UbiA PF01040.16 001145274.1_21023001_1 - 2.9e-57 193.7 14.8 4.1e-57 193.2 14.8 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF1510 PF07423.9 001035282.2_06529001_2 - 0.02 14.2 8.6 0.028 13.7 8.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) HA2 PF04408.21 001035282.2_06529001_2 - 0.064 13.5 0.3 0.11 12.7 0.3 1.4 1 0 0 1 1 1 0 Helicase associated domain (HA2) Folate_carrier PF01770.16 001035282.2_06529001_2 - 0.1 11.2 6.0 0.13 10.8 6.0 1.0 1 0 0 1 1 1 0 Reduced folate carrier G0-G1_switch_2 PF15103.4 001035282.2_06529001_2 - 0.52 10.6 7.1 0.94 9.8 7.1 1.4 1 0 0 1 1 1 0 G0/G1 switch protein 2 SR-25 PF10500.7 001035282.2_06529001_2 - 0.96 8.9 37.2 2 7.8 37.2 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein EIIBC-GUT_N PF03612.12 001035282.2_06529001_2 - 1 8.9 9.3 1.5 8.4 9.3 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus 7tm_1 PF00001.19 001035282.2_06529001_2 - 2.5 7.1 8.6 3.7 6.6 8.6 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Coilin_N PF15862.3 001035282.2_06529001_2 - 3.8 7.2 23.9 5.9 6.6 23.9 1.2 1 0 0 1 1 1 0 Coilin N-terminus Connexin PF00029.17 001035282.2_06529001_2 - 3.9 7.0 11.0 5.9 6.5 11.0 1.2 1 0 0 1 1 1 0 Connexin DAGK_acc PF00609.17 001035282.2_06529001_3 - 5.6e-51 172.9 0.0 1.2e-50 171.9 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.22 001035282.2_06529001_3 - 3.2e-27 94.5 0.0 8e-27 93.2 0.0 1.7 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain SAM_2 PF07647.15 001035282.2_06529001_3 - 1.9e-19 69.4 0.3 5.5e-19 67.9 0.1 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) C1_1 PF00130.20 001035282.2_06529001_3 - 8.3e-18 63.9 25.1 2.7e-09 36.6 5.5 2.8 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) SAM_1 PF00536.28 001035282.2_06529001_3 - 4.7e-17 62.1 1.5 6.1e-17 61.7 0.3 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PH PF00169.27 001035282.2_06529001_3 - 5.3e-12 46.0 0.1 5.3e-12 46.0 0.1 2.4 3 0 0 3 3 3 1 PH domain C1_2 PF03107.14 001035282.2_06529001_3 - 0.0053 16.9 16.1 0.021 15.0 5.8 2.7 2 0 0 2 2 2 2 C1 domain adh_short PF00106.23 001081926.2_21024001_1 - 6.6e-45 152.8 0.0 8.2e-45 152.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001081926.2_21024001_1 - 2.2e-23 82.9 0.0 3.2e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.8 001081926.2_21024001_1 - 0.0017 17.6 0.0 0.0035 16.6 0.0 1.5 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) KR PF08659.8 001081926.2_21024001_1 - 0.16 11.7 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 KR domain Defensin_propep PF00879.16 001166097.1_21021001_1 - 6e-22 77.6 5.6 7.7e-22 77.2 5.6 1.1 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166097.1_21021001_1 - 2.3e-09 37.5 13.5 2.3e-09 37.5 13.5 1.5 2 0 0 2 2 2 1 Mammalian defensin Ank_2 PF12796.5 001171173.1_21026001_3 - 4.3e-19 68.7 4.0 1.8e-10 41.1 0.4 2.7 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001171173.1_21026001_3 - 7.1e-17 61.1 1.6 6e-08 32.7 0.0 4.0 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 001171173.1_21026001_3 - 1.2e-14 54.4 1.0 2.6e-06 27.7 0.0 3.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 001171173.1_21026001_3 - 2.5e-12 45.7 2.6 1.5e-05 24.8 0.0 4.5 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.28 001171173.1_21026001_3 - 3.6e-09 36.5 2.0 0.00038 20.6 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat Chromo PF00385.22 001171173.1_21026001_3 - 7.5e-09 35.2 0.6 2.3e-08 33.7 0.6 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Bromodomain PF00439.23 001206018.1_06528001_1 - 5.4e-21 74.3 1.1 1.3e-20 73.1 1.1 1.7 1 0 0 1 1 1 1 Bromodomain zf-B_box PF00643.22 001206018.1_06528001_1 - 1.2e-11 44.4 19.8 2.2e-09 37.2 6.7 4.8 5 0 0 5 5 5 2 B-box zinc finger PHD PF00628.27 001206018.1_06528001_1 - 1.4e-07 31.2 10.0 1.4e-07 31.2 10.0 5.0 5 0 0 5 5 5 1 PHD-finger zf-RING_UBOX PF13445.4 001206018.1_06528001_1 - 2.1e-07 30.7 1.5 2.1e-07 30.7 1.5 3.6 2 1 1 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.4 001206018.1_06528001_1 - 4.8e-05 23.1 3.0 4.8e-05 23.1 3.0 4.0 3 2 0 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.4 001206018.1_06528001_1 - 0.0044 17.1 7.0 0.0044 17.1 7.0 4.6 4 1 0 4 4 4 1 Ring finger domain zf-C3HC4 PF00097.23 001206018.1_06528001_1 - 0.0055 16.4 1.5 0.0055 16.4 1.5 4.3 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001206018.1_06528001_1 - 0.014 15.1 1.4 0.014 15.1 1.4 4.8 5 0 0 5 5 5 0 Zinc finger, C3HC4 type (RING finger) DUF2180 PF09947.7 001206018.1_06528001_1 - 5.7 6.9 9.8 1.3e+02 2.5 9.8 3.1 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2180) Exonuc_VII_L PF02601.13 001206018.1_06528001_1 - 7.9 5.8 12.6 10 5.4 4.4 2.4 2 0 0 2 2 2 0 Exonuclease VII, large subunit Interferon PF00143.17 001114537.2_21022001_1 - 1.6e-69 233.1 0.2 1.8e-69 232.9 0.2 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain 7tm_1 PF00001.19 001257129.1_21023001_1 - 2e-52 177.9 12.5 2.7e-52 177.5 12.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001257129.1_21023001_1 - 1.2e-15 57.5 11.9 1.6e-15 57.1 11.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001257129.1_21023001_1 - 0.0032 16.7 9.8 0.0032 16.7 9.8 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001257129.1_21023001_1 - 0.0034 17.0 13.9 0.0063 16.1 13.9 1.4 1 1 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001192842.1_06525001_1 - 1.9e-70 237.0 4.0 2.5e-70 236.6 4.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001192842.1_06525001_1 - 0.00011 21.5 0.4 0.00023 20.5 0.4 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx zf-RING_UBOX PF13445.4 001205305.1_06526001_1 - 9.2e-13 47.8 3.9 1.7e-12 47.0 2.5 2.3 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 001205305.1_06526001_1 - 2.1e-11 43.6 7.1 2.1e-11 43.6 7.1 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001205305.1_06526001_1 - 1.3e-09 37.6 6.6 3.3e-09 36.3 6.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001205305.1_06526001_1 - 5.2e-09 36.0 2.9 5.2e-09 36.0 2.9 2.9 2 0 0 2 2 2 1 B-box zinc finger zf-RING_2 PF13639.4 001205305.1_06526001_1 - 5.1e-08 32.9 6.0 1.6e-07 31.3 6.0 2.0 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 001205305.1_06526001_1 - 3.3e-07 29.9 7.9 1.3e-06 28.0 7.9 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001205305.1_06526001_1 - 8.1e-07 28.7 4.2 8.1e-07 28.7 4.2 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001205305.1_06526001_1 - 1e-06 28.5 5.7 1e-06 28.5 5.7 2.2 2 0 0 2 2 1 1 zinc-RING finger domain SPRY PF00622.26 001205305.1_06526001_1 - 2.5e-06 27.5 0.1 4.8e-06 26.5 0.1 1.5 1 0 0 1 1 1 1 SPRY domain U-box PF04564.13 001205305.1_06526001_1 - 0.0014 18.7 0.0 0.0031 17.5 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-RING_10 PF16685.3 001205305.1_06526001_1 - 0.0068 16.4 2.4 0.0068 16.4 2.4 2.1 2 0 0 2 2 2 1 zinc RING finger of MSL2 zf-Nse PF11789.6 001205305.1_06526001_1 - 0.0073 16.0 3.6 0.019 14.6 3.6 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.4 001205305.1_06526001_1 - 0.028 14.1 1.9 0.087 12.6 1.9 1.9 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Prok-RING_4 PF14447.4 001205305.1_06526001_1 - 0.036 13.8 11.1 0.032 13.9 7.7 2.7 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.5 001205305.1_06526001_1 - 0.046 13.9 3.9 0.18 12.0 3.9 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain Bacillus_HBL PF05791.9 001205305.1_06526001_1 - 0.074 12.6 2.7 0.13 11.8 2.7 1.4 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) zf-RING_11 PF17123.3 001205305.1_06526001_1 - 4.6 6.9 6.6 7.4 6.3 4.5 2.5 2 0 0 2 2 2 0 RING-like zinc finger Selenoprotein_S PF06936.9 001199732.1_21023001_3 - 3.2e-93 310.8 1.1 4.5e-93 310.3 1.1 1.1 1 0 0 1 1 1 1 Selenoprotein S (SelS) SMC_N PF02463.17 001308957.1_21029001_3 - 3e-62 209.8 30.4 6.3e-62 208.7 30.4 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.11 001308957.1_21029001_3 - 5.8e-21 74.8 0.0 1.5e-20 73.5 0.0 1.8 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.4 001308957.1_21029001_3 - 8.2e-13 48.6 19.2 8.2e-13 48.6 19.2 4.9 2 2 2 4 4 4 1 AAA ATPase domain AAA_21 PF13304.4 001308957.1_21029001_3 - 8.4e-10 38.8 21.7 3.7e-06 26.8 0.0 5.4 4 2 1 6 6 6 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.4 001308957.1_21029001_3 - 4.7e-09 36.9 46.5 4.7e-09 36.9 46.5 8.0 2 2 2 4 4 4 1 AAA domain AAA_29 PF13555.4 001308957.1_21029001_3 - 0.003 17.1 0.0 0.0064 16.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Reo_sigmaC PF04582.10 001308957.1_21029001_3 - 0.34 10.1 24.8 3.1 7.0 0.2 4.4 3 1 0 4 4 4 0 Reovirus sigma C capsid protein ABC_tran PF00005.25 001308957.1_21029001_3 - 1.6 9.1 0.0 1.6 9.1 0.0 6.9 2 2 2 4 4 4 0 ABC transporter Baculo_PEP_C PF04513.10 001308957.1_21029001_3 - 5.2 7.0 38.9 0.18 11.7 0.3 6.6 4 2 2 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus Rad51 PF08423.9 001309266.1_21023001_3 - 3.1e-16 59.3 0.0 4.1e-16 58.9 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.4 001309266.1_21023001_3 - 0.0042 16.6 0.0 0.0081 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain Tap-RNA_bind PF09162.8 001309393.1_21025001_1 - 1.6e-38 130.3 0.3 3.7e-38 129.1 0.3 1.6 1 0 0 1 1 1 1 Tap, RNA-binding NTF2 PF02136.18 001309393.1_21025001_1 - 2.5e-27 95.7 0.0 4.3e-27 94.9 0.0 1.4 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain TAP_C PF03943.11 001309393.1_21025001_1 - 3.5e-25 87.2 0.9 6.1e-25 86.4 0.9 1.4 1 0 0 1 1 1 1 TAP C-terminal domain LRR_4 PF12799.5 001309393.1_21025001_1 - 2.2e-06 27.8 7.9 0.00072 19.7 0.9 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001309393.1_21025001_1 - 0.00061 19.4 6.9 0.0017 18.0 6.8 1.9 1 1 0 1 1 1 1 Leucine rich repeat LRR_1 PF00560.31 001309393.1_21025001_1 - 0.016 15.4 5.2 5.7 7.7 0.2 4.0 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_9 PF14580.4 001309393.1_21025001_1 - 0.022 14.1 0.4 0.042 13.2 0.4 1.4 1 0 0 1 1 1 0 Leucine-rich repeat LRR_6 PF13516.4 001309393.1_21025001_1 - 0.53 10.3 3.8 2.2 8.4 0.0 2.8 3 0 0 3 3 3 0 Leucine Rich repeat TFR_dimer PF04253.13 001192880.1_06525001_1 - 1.5e-33 115.4 0.0 3.1e-33 114.3 0.0 1.6 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.15 001192880.1_06525001_1 - 2.2e-20 73.1 0.0 2e-19 69.9 0.0 2.1 2 0 0 2 2 2 1 Peptidase family M28 PA PF02225.20 001192880.1_06525001_1 - 2e-12 46.9 0.0 5.2e-12 45.6 0.0 1.7 1 0 0 1 1 1 1 PA domain PPR_3 PF13812.4 001192880.1_06525001_1 - 0.12 12.4 0.2 0.45 10.5 0.0 2.1 3 0 0 3 3 3 0 Pentatricopeptide repeat domain WD40 PF00400.30 001301270.1_21027001_1 - 7.6e-38 127.7 21.3 4.6e-09 36.6 0.6 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001301270.1_21027001_1 - 0.00031 20.8 2.8 0.73 10.0 0.1 4.6 3 2 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.9 001301270.1_21027001_1 - 0.0025 16.5 0.3 1.9 7.0 0.0 3.4 1 1 1 3 3 3 1 Nup133 N terminal like BBS2_Mid PF14783.4 001301270.1_21027001_1 - 0.025 14.5 0.0 16 5.5 0.0 3.7 4 1 1 5 5 5 0 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.6 001301270.1_21027001_1 - 0.029 12.9 4.0 1.2 7.5 0.5 3.5 1 1 3 4 4 4 0 Nucleoporin Nup120/160 UCH PF00443.27 001271992.1_06529001_1 - 1.2e-62 211.6 0.9 1.8e-62 211.0 0.9 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_N PF16674.3 001271992.1_06529001_1 - 1.4e-44 150.2 0.0 2.6e-44 149.3 0.0 1.5 1 0 0 1 1 1 1 N-terminal of ubiquitin carboxyl-terminal hydrolase 37 UCH_1 PF13423.4 001271992.1_06529001_1 - 3.3e-17 62.9 11.9 2.9e-14 53.3 11.9 2.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UIM PF02809.18 001271992.1_06529001_1 - 1.1e-06 28.1 21.3 0.00064 19.3 0.2 3.7 3 0 0 3 3 3 3 Ubiquitin interaction motif IL8 PF00048.18 001114940.1_21021001_1 - 1.8e-16 59.9 1.3 2.7e-16 59.3 1.3 1.3 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like ISK_Channel PF02060.13 001289961.1_21022001_1 - 4.8e-63 210.2 0.0 6.4e-63 209.8 0.0 1.2 1 0 0 1 1 1 1 Slow voltage-gated potassium channel PLA2_B PF01735.16 001204234.1_21025001_1 - 1.9e-30 105.6 0.0 5.8e-30 104.0 0.0 1.7 2 0 0 2 2 2 1 Lysophospholipase catalytic domain C2 PF00168.28 001204234.1_21025001_1 - 7.7e-20 71.0 0.0 1.7e-19 69.9 0.0 1.6 1 0 0 1 1 1 1 C2 domain ig PF00047.23 001267799.2_21024001_3 - 5.5e-09 35.9 0.0 0.00015 21.7 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 001267799.2_21024001_3 - 1.7e-08 34.5 0.0 9.2e-06 25.7 0.0 3.3 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001267799.2_21024001_3 - 5.1e-07 30.1 0.0 0.017 15.6 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001267799.2_21024001_3 - 1.2e-05 25.4 0.0 0.037 14.2 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001267799.2_21024001_3 - 0.02 14.8 0.0 0.066 13.2 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin I-set domain V-set_CD47 PF08204.9 001267799.2_21024001_3 - 0.1 12.5 0.0 0.42 10.5 0.0 1.8 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain MAGE PF01454.17 001046125.2_06526001_3 - 1.3e-19 70.6 0.0 2.8e-17 63.0 0.0 2.5 1 1 0 1 1 1 1 MAGE family 7tm_2 PF00002.22 001076269.2_06526001_1 - 5.1e-78 261.6 18.9 9e-78 260.8 18.9 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 001076269.2_06526001_1 - 2.9e-19 69.0 7.3 5.2e-19 68.2 7.3 1.4 1 0 0 1 1 1 1 Hormone receptor domain RTP1_C1 PF10363.7 001076269.2_06526001_1 - 0.1 12.6 0.1 0.24 11.5 0.1 1.5 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 PELOTA_1 PF15608.4 001076269.2_06526001_2 - 0.71 9.7 5.6 3.1 7.6 0.6 2.4 1 1 1 2 2 2 0 PELOTA RNA binding domain PRIMA1 PF16101.3 001076269.2_06526001_2 - 5 7.0 13.4 1.2 9.0 8.3 2.3 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 T4_deiodinase PF00837.15 001166455.1_21029001_2 - 1.2e-108 361.7 0.0 1.6e-108 361.3 0.0 1.1 1 0 0 1 1 1 1 Iodothyronine deiodinase Defensin_propep PF00879.16 001166074.1_21021001_1 - 1.5e-22 79.5 2.9 2e-22 79.1 2.9 1.1 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166074.1_21021001_1 - 0.00038 20.8 12.1 0.00053 20.3 12.1 1.2 1 0 0 1 1 1 1 Mammalian defensin Defensin_propep PF00879.16 001166083.1_21021001_1 - 1.7e-22 79.3 1.8 2.3e-22 78.9 1.8 1.2 1 0 0 1 1 1 1 Defensin propeptide CDRN PF05174.10 001166083.1_21021001_2 - 0.12 12.0 0.2 0.27 10.8 0.0 1.7 2 0 0 2 2 2 0 Cysteine-rich D. radiodurans N terminus Kisspeptin PF15152.4 001289144.1_21022001_2 - 2.4e-35 121.0 0.8 3.7e-35 120.4 0.8 1.3 1 0 0 1 1 1 1 Kisspeptin CDC27 PF09507.8 001100414.2_21024001_2 - 1.4e-128 429.8 35.6 1.6e-128 429.6 35.6 1.0 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 Filament PF00038.19 001346200.1_21025001_1 - 1.8e-100 336.4 31.8 2.1e-100 336.2 31.8 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001346200.1_21025001_1 - 3.1e-13 50.1 1.8 3.1e-13 50.1 1.8 2.1 2 0 0 2 2 2 1 Keratin type II head TPR_MLP1_2 PF07926.10 001346200.1_21025001_1 - 1.1e-06 28.6 26.5 0.0001 22.2 0.8 3.4 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein Spc7 PF08317.9 001346200.1_21025001_1 - 0.0016 17.2 25.7 0.031 13.0 12.5 3.0 1 1 0 2 2 2 2 Spc7 kinetochore protein BRE1 PF08647.9 001346200.1_21025001_1 - 0.013 15.5 0.7 0.013 15.5 0.7 3.4 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase Tropomyosin_1 PF12718.5 001346200.1_21025001_1 - 0.014 15.4 10.2 0.014 15.4 10.2 3.6 3 1 1 4 4 4 0 Tropomyosin like BAT PF15915.3 001346200.1_21025001_1 - 0.022 14.5 0.4 0.049 13.4 0.3 1.6 1 1 0 1 1 1 0 GAF and HTH_10 associated domain DUF3355 PF11835.6 001346200.1_21025001_1 - 0.033 13.8 0.7 0.083 12.5 0.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3355) Alanine_zipper PF11839.6 001346200.1_21025001_1 - 0.049 13.8 7.3 0.055 13.6 5.8 1.8 2 0 0 2 2 1 0 Alanine-zipper, major outer membrane lipoprotein DUF1635 PF07795.9 001346200.1_21025001_1 - 0.061 13.2 4.4 0.13 12.1 4.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) MRFAP1 PF15155.4 001346200.1_21025001_1 - 0.082 13.3 6.6 0.088 13.2 3.3 2.5 2 1 0 2 2 2 0 MORF4 family-associated protein1 DUF1192 PF06698.9 001346200.1_21025001_1 - 0.09 12.7 7.0 0.6 10.1 0.6 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) CALCOCO1 PF07888.9 001346200.1_21025001_1 - 0.32 9.4 21.4 0.11 10.9 9.8 2.2 1 1 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF641 PF04859.10 001346200.1_21025001_1 - 0.51 10.5 11.6 2 8.6 2.8 2.5 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Reo_sigmaC PF04582.10 001346200.1_21025001_1 - 0.65 9.2 3.2 2.3 7.4 1.1 2.0 1 1 1 2 2 2 0 Reovirus sigma C capsid protein DASH_Dad4 PF08650.8 001346200.1_21025001_1 - 0.82 9.6 5.3 0.3 11.0 1.2 2.4 2 0 0 2 2 2 0 DASH complex subunit Dad4 ADIP PF11559.6 001346200.1_21025001_1 - 1.2 9.0 21.8 0.054 13.5 7.5 3.4 3 1 0 3 3 3 0 Afadin- and alpha -actinin-Binding FlaC_arch PF05377.9 001346200.1_21025001_1 - 1.6 9.0 9.6 7.8 6.8 2.4 4.1 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) DASH_Duo1 PF08651.8 001346200.1_21025001_1 - 1.7 8.3 8.4 0.4 10.4 3.0 2.6 3 0 0 3 3 2 0 DASH complex subunit Duo1 DUF4200 PF13863.4 001346200.1_21025001_1 - 1.7 8.9 21.8 2.8 8.2 3.6 3.2 2 2 0 2 2 2 0 Domain of unknown function (DUF4200) TSNAXIP1_N PF15739.3 001346200.1_21025001_1 - 1.8 8.8 13.9 0.032 14.5 2.4 3.2 2 2 2 4 4 4 0 Translin-associated factor X-interacting N-terminus CHDCT2 PF08074.9 001346200.1_21025001_1 - 1.9 8.5 11.1 0.91 9.5 1.0 2.7 1 1 2 3 3 3 0 CHDCT2 (NUC038) domain DUF1664 PF07889.10 001346200.1_21025001_1 - 2 8.3 8.8 8.6 6.2 2.3 3.4 1 1 2 4 4 4 0 Protein of unknown function (DUF1664) DUF4407 PF14362.4 001346200.1_21025001_1 - 2.1 7.5 17.5 2.9e+02 0.5 17.5 2.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Virulence_fact PF13769.4 001346200.1_21025001_1 - 2.4 8.2 5.3 1.9 8.5 0.1 3.0 3 0 0 3 3 3 0 Virulence factor Nsp1_C PF05064.11 001346200.1_21025001_1 - 5.5 6.7 9.7 3.4 7.4 3.0 2.7 1 1 2 3 3 3 0 Nsp1-like C-terminal region Med9 PF07544.11 001346200.1_21025001_1 - 7.2 6.6 7.7 2.9 7.9 4.2 2.2 2 0 0 2 2 1 0 RNA polymerase II transcription mediator complex subunit 9 7tm_1 PF00001.19 001309175.1_21023001_1 - 5.4e-33 114.2 19.5 8.8e-33 113.5 19.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) ADAM_spacer1 PF05986.12 001111299.2_21026001_1 - 2.9e-30 104.5 0.0 4.6e-30 103.8 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Reprolysin PF01421.17 001111299.2_21026001_1 - 9e-15 55.0 0.0 1.4e-14 54.3 0.0 1.4 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.4 001111299.2_21026001_1 - 2.6e-09 37.4 0.0 4.9e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 001111299.2_21026001_1 - 3.5e-09 37.1 0.0 5e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Pep_M12B_propep PF01562.17 001111299.2_21026001_1 - 1.5e-08 34.9 0.0 2.5e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide TSP_1 PF00090.17 001111299.2_21026001_1 - 7.4e-08 32.4 9.9 7.4e-08 32.4 9.9 4.1 4 0 0 4 4 4 1 Thrombospondin type 1 domain Reprolysin_2 PF13574.4 001111299.2_21026001_1 - 3.1e-05 23.8 0.1 5.2e-05 23.1 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 001111299.2_21026001_1 - 0.0011 18.5 0.0 0.0017 17.9 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like PACT_coil_coil PF10495.7 001301258.1_21029001_2 - 3.5e-25 88.3 0.1 3.5e-25 88.3 0.1 7.2 7 0 0 7 7 7 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein T4_deiodinase PF00837.15 001166452.1_21024001_1 - 2.2e-106 354.3 0.1 2.7e-106 354.0 0.1 1.1 1 0 0 1 1 1 1 Iodothyronine deiodinase ecTbetaR2 PF08917.8 001301147.1_21029001_3 - 3.5e-41 139.4 17.2 7.3e-41 138.4 17.2 1.6 1 0 0 1 1 1 1 Transforming growth factor beta receptor 2 ectodomain Pkinase_Tyr PF07714.15 001301147.1_21029001_3 - 1e-35 123.2 0.0 1.6e-35 122.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001301147.1_21029001_3 - 1.5e-34 119.5 0.0 2.2e-34 118.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.21 001301147.1_21029001_3 - 0.11 12.3 0.1 0.18 11.6 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family MHC_II_alpha PF00993.18 001142812.1_21023001_1 - 3e-36 122.8 0.0 4.2e-36 122.4 0.0 1.2 1 0 0 1 1 1 1 Class II histocompatibility antigen, alpha domain C1-set_C PF16196.3 001142812.1_21023001_1 - 2.7e-28 97.0 0.8 5.7e-28 96.0 0.8 1.6 1 0 0 1 1 1 1 C1-set C-terminal domain C1-set PF07654.13 001142812.1_21023001_1 - 1.8e-24 85.9 0.0 2.9e-24 85.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001142812.1_21023001_1 - 0.00031 21.2 0.0 0.00056 20.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Marek_A PF02124.13 001142812.1_21023001_1 - 0.0023 17.7 0.0 0.0035 17.1 0.0 1.2 1 0 0 1 1 1 1 Marek's disease glycoprotein A C2-set_2 PF08205.10 001142812.1_21023001_1 - 0.006 16.5 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain SKG6 PF08693.8 001142812.1_21023001_1 - 0.14 11.4 2.0 0.28 10.5 2.0 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF1797 PF08796.8 001142812.1_21023001_1 - 0.16 12.0 0.1 0.29 11.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1797) Cpn60_TCP1 PF00118.22 001257186.1_21025001_1 - 5.5e-22 77.9 0.1 2.3e-10 39.6 0.0 2.3 2 1 0 2 2 2 2 TCP-1/cpn60 chaperonin family RabGAP-TBC PF00566.16 001309161.1_21028001_1 - 9.7e-50 169.1 11.5 1.6e-49 168.4 11.5 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF3548 PF12068.6 001309161.1_21028001_1 - 1.8e-39 135.3 0.5 3e-39 134.5 0.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3548) G-gamma PF00631.20 001114512.2_06523001_1 - 9.6e-15 54.2 0.0 1.5e-14 53.6 0.0 1.3 1 0 0 1 1 1 1 GGL domain GDI PF00996.16 001256975.1_21024001_1 - 2.1e-56 191.2 0.1 3e-43 147.8 0.1 2.1 2 0 0 2 2 2 2 GDP dissociation inhibitor NAD_binding_8 PF13450.4 001256975.1_21024001_1 - 0.0015 18.6 0.0 0.0038 17.3 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.5 001256975.1_21024001_1 - 0.053 12.7 0.0 0.088 12.0 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.22 001256975.1_21024001_1 - 0.053 12.5 0.0 0.081 11.9 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain DUF4321 PF14209.4 001257104.1_21022001_1 - 0.34 10.6 0.1 0.34 10.6 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4321) Folate_rec PF03024.12 001206530.1_06523001_3 - 1.3e-63 213.8 23.2 1.6e-63 213.5 23.2 1.1 1 0 0 1 1 1 1 Folate receptor family V-SNARE_C PF12352.6 001301246.1_21029001_3 - 2.5e-21 75.6 3.3 2.5e-21 75.6 3.3 1.9 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus 7tm_1 PF00001.19 001257152.1_21023001_1 - 5.1e-38 130.7 21.0 1.5e-37 129.2 21.0 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GLTP PF08718.9 001197039.2_21024001_3 - 1e-42 145.8 0.0 2.2e-42 144.7 0.0 1.5 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) PH PF00169.27 001197039.2_21024001_3 - 7.7e-12 45.5 0.0 2e-11 44.2 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 001197039.2_21024001_3 - 5.5e-05 23.2 0.0 0.0002 21.5 0.0 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.4 001197039.2_21024001_3 - 0.00019 21.6 1.4 0.00081 19.6 0.3 2.6 2 1 0 2 2 2 1 Pleckstrin homology domain AKNA PF12443.6 001197039.2_21024001_3 - 0.058 13.9 0.2 0.13 12.8 0.2 1.5 1 0 0 1 1 1 0 AT-hook-containing transcription factor PH_3 PF14593.4 001197039.2_21024001_3 - 0.083 12.9 0.0 0.49 10.4 0.0 2.2 1 1 1 2 2 2 0 PH domain PRKCSH PF07915.11 001167682.2_21025001_1 - 1.5e-15 57.8 5.0 1.5e-15 57.8 5.0 2.4 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.4 001167682.2_21025001_1 - 0.0022 17.6 0.0 0.0048 16.5 0.0 1.5 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein DNA_pol_phi PF04931.11 001167682.2_21025001_1 - 0.11 10.4 17.3 0.2 9.6 17.3 1.3 1 0 0 1 1 1 0 DNA polymerase phi ATG27 PF09451.8 001167682.2_21025001_1 - 0.16 11.6 0.0 0.29 10.8 0.0 1.3 1 0 0 1 1 1 0 Autophagy-related protein 27 Astro_capsid_p PF12226.6 001167682.2_21025001_1 - 0.52 9.3 6.3 0.82 8.6 6.3 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein CDC27 PF09507.8 001167682.2_21025001_1 - 5.5 6.1 22.1 11 5.2 22.1 1.4 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 EIF4E-T PF10477.7 001301265.1_21027001_1 - 9.8e-175 582.9 8.5 1.9e-174 581.9 8.5 1.5 1 0 0 1 1 1 1 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Glycolytic PF00274.17 001301265.1_21027001_1 - 0.039 12.6 0.0 0.061 11.9 0.0 1.1 1 0 0 1 1 1 0 Fructose-bisphosphate aldolase class-I V_ATPase_I PF01496.17 001205851.2_06527001_1 - 0 1074.7 6.5 0 1074.5 6.5 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Uso1_p115_C PF04871.11 001205851.2_06527001_1 - 0.24 11.6 2.8 8.5 6.6 0.0 2.2 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region TIR_2 PF13676.4 001202854.1_21027001_2 - 1.3e-07 31.8 0.0 8.9e-07 29.1 0.0 2.0 2 0 0 2 2 2 1 TIR domain TIR PF01582.18 001202854.1_21027001_2 - 0.0019 17.9 0.0 0.0042 16.8 0.0 1.5 1 0 0 1 1 1 1 TIR domain Defensin_propep PF00879.16 001166233.1_21021001_1 - 1.3e-18 67.0 3.8 1.7e-18 66.5 3.8 1.2 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166233.1_21021001_2 - 0.0025 18.2 0.3 0.0045 17.4 0.3 1.4 1 0 0 1 1 1 1 Mammalian defensin DDE_1 PF03184.17 001242454.1_21024001_1 - 1.3e-42 145.2 1.2 2.2e-42 144.5 1.2 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.14 001242454.1_21024001_1 - 3.4e-16 58.9 0.0 6.3e-16 58.0 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.11 001242454.1_21024001_1 - 2.1e-11 43.1 0.1 4.1e-11 42.2 0.1 1.5 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_Tnp_1 PF01527.18 001242454.1_21024001_1 - 4.8e-05 23.5 0.3 0.00011 22.3 0.3 1.6 1 0 0 1 1 1 1 Transposase HTH_28 PF13518.4 001242454.1_21024001_1 - 6.7e-05 22.8 0.0 0.0025 17.8 0.0 2.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.4 001242454.1_21024001_1 - 9.4e-05 22.0 0.0 0.0012 18.5 0.0 2.7 3 0 0 3 3 3 1 Homeodomain-like domain DUF3837 PF12939.5 001242454.1_21024001_1 - 0.01 16.1 0.0 0.027 14.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3837) HTH_7 PF02796.13 001242454.1_21024001_1 - 0.025 14.5 0.0 0.086 12.8 0.0 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HTH_Tnp_IS630 PF01710.14 001242454.1_21024001_1 - 0.065 13.2 0.6 0.17 11.8 0.6 1.7 1 0 0 1 1 1 0 Transposase LacI PF00356.19 001242454.1_21024001_1 - 0.14 11.8 0.0 0.36 10.5 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family KH_1 PF00013.27 001308349.1_21026001_1 - 1.6e-42 143.0 13.9 1e-19 70.0 1.9 3.3 3 0 0 3 3 3 3 KH domain ROKNT PF08067.9 001308349.1_21026001_1 - 2.9e-26 91.3 9.8 4.8e-26 90.6 9.8 1.3 1 0 0 1 1 1 1 ROKNT (NUC014) domain KH_2 PF07650.15 001308349.1_21026001_1 - 4.8e-13 48.6 7.0 0.0014 18.3 0.5 3.7 3 1 1 4 4 4 3 KH domain KH_4 PF13083.4 001308349.1_21026001_1 - 8.3e-08 31.9 5.2 1.2e-05 25.0 0.0 3.1 3 0 0 3 3 3 2 KH domain KH_5 PF13184.4 001308349.1_21026001_1 - 0.00015 21.6 3.0 0.55 10.2 0.1 3.6 3 0 0 3 3 3 2 NusA-like KH domain MOEP19 PF16005.3 001308349.1_21026001_1 - 0.091 12.7 0.0 2.8 7.9 0.0 2.3 2 0 0 2 2 2 0 KH-like RNA-binding domain DJ-1_PfpI PF01965.22 001308349.1_21026001_1 - 0.16 11.7 0.0 0.32 10.6 0.0 1.4 1 0 0 1 1 1 0 DJ-1/PfpI family HD_assoc PF13286.4 001205828.1_06528001_1 - 0.68 10.4 5.3 0.11 12.9 0.6 2.1 2 0 0 2 2 2 0 Phosphohydrolase-associated domain V1R PF03402.12 001166856.1_21022001_1 - 9.4e-27 94.1 14.8 1.2e-26 93.8 14.8 1.0 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R TAS2R PF05296.11 001166856.1_21022001_1 - 2e-10 40.2 17.5 2.4e-10 39.9 17.5 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Pkinase PF00069.23 001242549.1_21029001_1 - 2.8e-32 112.0 0.0 4.6e-32 111.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001242549.1_21029001_1 - 4.8e-30 104.6 0.0 6.8e-30 104.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Activin_recp PF01064.21 001242549.1_21029001_1 - 5.7e-05 24.0 12.0 5.7e-05 24.0 12.0 2.5 2 0 0 2 2 2 1 Activin types I and II receptor domain EF_assoc_2 PF08356.10 001309223.1_21027001_1 - 1.9e-35 120.6 0.0 5.1e-35 119.2 0.0 1.8 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.10 001309223.1_21027001_1 - 1.9e-29 101.0 2.1 7.8e-29 99.0 0.9 2.2 2 0 0 2 2 2 1 EF hand associated Ras PF00071.20 001309223.1_21027001_1 - 1.6e-23 83.0 0.2 7.3e-17 61.3 0.0 2.6 2 1 0 2 2 2 2 Ras family Roc PF08477.11 001309223.1_21027001_1 - 1.7e-07 31.4 0.0 5.8e-05 23.2 0.0 3.2 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase EF-hand_7 PF13499.4 001309223.1_21027001_1 - 1.5e-05 25.2 1.0 0.018 15.4 0.0 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.30 001309223.1_21027001_1 - 1.8e-05 23.8 3.2 0.11 12.0 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 001309223.1_21027001_1 - 5.7e-05 22.6 4.1 0.017 14.9 0.2 3.0 3 0 0 3 3 2 2 EF-hand domain Rad4 PF03835.13 001309223.1_21027001_1 - 0.0042 16.6 0.0 0.0082 15.7 0.0 1.4 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain MMR_HSR1 PF01926.21 001309223.1_21027001_1 - 0.015 15.3 0.2 1.3 9.0 0.1 2.8 2 1 0 2 2 2 0 50S ribosome-binding GTPase EF-hand_8 PF13833.4 001309223.1_21027001_1 - 0.088 12.5 1.1 1.6 8.4 0.1 2.6 2 0 0 2 2 2 0 EF-hand domain pair Dynamin_N PF00350.21 001309223.1_21027001_1 - 0.099 12.6 0.2 1.5 8.7 0.1 2.3 2 0 0 2 2 2 0 Dynamin family PduV-EutP PF10662.7 001309223.1_21027001_1 - 0.13 11.9 0.3 1.8 8.1 0.0 2.7 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation EF-hand_5 PF13202.4 001309223.1_21027001_1 - 0.22 11.0 2.8 2.7 7.5 0.1 2.5 2 0 0 2 2 2 0 EF hand SBF PF01758.14 001257077.1_21023001_1 - 1.7e-35 122.3 13.2 3.3e-35 121.4 13.2 1.4 1 0 0 1 1 1 1 Sodium Bile acid symporter family TMEM43 PF07787.10 001257077.1_21023001_1 - 9.4 5.4 9.1 0.3 10.3 2.5 1.8 1 1 1 2 2 2 0 Transmembrane protein 43 Filament PF00038.19 001346165.1_21023001_2 - 7e-109 364.0 38.5 7.9e-109 363.9 38.5 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 001346165.1_21023001_2 - 0.0058 16.6 4.3 0.0058 16.6 4.3 4.1 2 2 1 4 4 4 2 TPR/MLP1/MLP2-like protein Gp58 PF07902.9 001346165.1_21023001_2 - 0.0061 14.9 14.3 0.005 15.2 12.8 1.5 1 1 1 2 2 2 1 gp58-like protein Lzipper-MIP1 PF14389.4 001346165.1_21023001_2 - 0.0064 16.6 4.3 0.0064 16.6 4.3 4.6 3 2 0 3 3 3 1 Leucine-zipper of ternary complex factor MIP1 Baculo_PEP_C PF04513.10 001346165.1_21023001_2 - 0.033 14.1 22.0 0.53 10.2 12.7 3.3 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus TNF PF00229.16 001346165.1_21023001_2 - 0.042 13.7 2.9 0.41 10.5 0.1 2.9 3 0 0 3 3 3 0 TNF(Tumour Necrosis Factor) family DUF4677 PF15726.3 001346165.1_21023001_2 - 0.055 13.5 0.1 0.2 11.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4677) Fib_alpha PF08702.8 001346165.1_21023001_2 - 0.29 11.2 26.4 0.35 10.9 8.6 3.7 2 2 1 3 3 3 0 Fibrinogen alpha/beta chain family Uso1_p115_C PF04871.11 001346165.1_21023001_2 - 0.29 11.4 23.2 0.35 11.1 5.4 3.1 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Spc7 PF08317.9 001346165.1_21023001_2 - 0.54 9.0 33.0 0.41 9.3 11.4 2.5 1 1 0 2 2 2 0 Spc7 kinetochore protein DUF1664 PF07889.10 001346165.1_21023001_2 - 0.67 9.8 19.3 2.1 8.2 2.0 4.0 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) DUF4407 PF14362.4 001346165.1_21023001_2 - 1.1 8.4 20.6 7.8 5.6 12.9 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Jnk-SapK_ap_N PF09744.7 001346165.1_21023001_2 - 3 7.9 35.7 1.1 9.3 10.4 3.8 1 1 3 4 4 4 0 JNK_SAPK-associated protein-1 DUF5082 PF16888.3 001346165.1_21023001_2 - 3.2 8.0 23.3 2.1 8.6 9.9 4.0 2 2 1 3 3 3 0 Domain of unknown function (DUF5082) CREPT PF16566.3 001346165.1_21023001_2 - 9.9 6.2 27.2 7.9 6.5 3.3 3.6 1 1 2 4 4 4 0 Cell-cycle alteration and expression-elevated protein in tumour PWWP PF00855.15 001256976.1_21025001_1 - 6.4e-09 36.0 0.6 1.4e-05 25.3 0.2 3.1 2 0 0 2 2 2 2 PWWP domain DUF3246 PF11596.6 001256976.1_21025001_1 - 0.0034 16.7 7.1 0.006 15.9 7.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3246) Plant_tran PF04827.12 001256976.1_21025001_1 - 0.12 11.8 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 Plant transposon protein MAT1 PF06391.11 001256976.1_21025001_1 - 9.7 5.8 15.0 0.38 10.4 6.6 2.7 2 1 1 3 3 3 0 CDK-activating kinase assembly factor MAT1 Spindle_Spc25 PF08234.10 001309196.1_21022001_1 - 2.8e-22 78.6 1.3 4.8e-22 77.8 0.2 2.0 2 0 0 2 2 2 1 Chromosome segregation protein Spc25 Spc7 PF08317.9 001309196.1_21022001_1 - 5.2e-05 22.1 10.4 7.1e-05 21.7 10.4 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF3584 PF12128.6 001309196.1_21022001_1 - 0.0024 15.4 9.6 0.0029 15.1 9.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) SKA2 PF16740.3 001309196.1_21022001_1 - 0.023 14.3 8.6 0.033 13.8 7.3 1.9 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 2 COG5 PF10392.7 001309196.1_21022001_1 - 0.029 14.4 3.9 0.054 13.5 3.9 1.4 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Phyto_Pns9_10 PF05878.9 001309196.1_21022001_1 - 0.034 13.2 1.5 0.044 12.8 1.5 1.1 1 0 0 1 1 1 0 Phytoreovirus nonstructural protein Pns9/Pns10 Atg14 PF10186.7 001309196.1_21022001_1 - 0.037 13.0 10.6 0.05 12.5 10.6 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2779 PF11074.6 001309196.1_21022001_1 - 0.046 14.1 6.5 0.32 11.4 0.0 2.8 1 1 1 2 2 2 0 Domain of unknown function(DUF2779) DUF342 PF03961.11 001309196.1_21022001_1 - 0.09 11.2 8.8 0.11 10.9 8.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) PI3K_P85_iSH2 PF16454.3 001309196.1_21022001_1 - 0.099 12.1 13.8 0.19 11.2 12.0 2.0 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Exonuc_VII_L PF02601.13 001309196.1_21022001_1 - 0.13 11.7 3.1 0.14 11.6 3.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit ORF6N PF10543.7 001309196.1_21022001_1 - 0.13 12.4 6.1 3.2 7.9 0.5 3.1 1 1 2 3 3 3 0 ORF6N domain DUF4407 PF14362.4 001309196.1_21022001_1 - 0.37 9.9 6.8 0.53 9.4 6.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PspB PF06667.10 001309196.1_21022001_1 - 4.9 7.2 6.1 24 4.9 0.4 2.4 1 1 1 2 2 2 0 Phage shock protein B YtxH PF12732.5 001309196.1_21022001_1 - 8.2 6.9 7.1 8.8e+02 0.4 7.1 2.9 1 1 0 1 1 1 0 YtxH-like protein Nup54 PF13874.4 001309196.1_21022001_1 - 9.2 6.2 10.9 11 6.0 10.1 1.5 2 0 0 2 2 1 0 Nucleoporin complex subunit 54 Defensin_propep PF00879.16 001166099.1_21021001_1 - 4.6e-23 81.2 4.8 5.8e-23 80.8 4.8 1.1 1 0 0 1 1 1 1 Defensin propeptide Defensin_1 PF00323.17 001166099.1_21021001_1 - 0.00017 21.9 9.7 0.00017 21.9 9.7 1.8 2 0 0 2 2 2 1 Mammalian defensin DUF3357 PF11837.6 001166099.1_21021001_1 - 0.13 12.5 0.0 0.16 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) Casein PF00363.16 001170767.2_21022001_3 - 2e-12 47.5 10.5 2.7e-08 34.2 1.2 3.2 3 0 0 3 3 3 2 Casein zf-C2H2_jaz PF12171.6 001192613.2_06528001_1 - 0.00018 21.6 5.2 0.01 16.0 0.3 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 001192613.2_06528001_1 - 0.028 14.7 7.7 0.69 10.3 0.4 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-U1 PF06220.10 001192613.2_06528001_1 - 6.7 6.4 7.0 0.56 9.9 2.1 1.7 2 0 0 2 2 2 0 U1 zinc finger PHD20L1_u1 PF16660.3 001301263.1_21029001_3 - 9.1e-51 170.4 9.4 9.1e-51 170.4 9.4 2.7 2 0 0 2 2 2 1 PHD finger protein 20-like protein 1 DUF3776 PF12618.6 001301263.1_21029001_3 - 1.4e-30 105.5 3.0 1.4e-30 105.5 3.0 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3776) PHD PF00628.27 001301263.1_21029001_3 - 2.4e-06 27.2 11.2 2.4e-06 27.2 11.2 3.5 4 0 0 4 4 4 1 PHD-finger MBT PF02820.16 001301263.1_21029001_3 - 1.8e-05 24.9 0.1 0.00019 21.6 0.0 2.3 2 0 0 2 2 2 1 mbt repeat DUF4537 PF15057.4 001301263.1_21029001_3 - 0.0083 16.0 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) LBR_tudor PF09465.8 001301263.1_21029001_3 - 0.015 14.9 0.0 0.034 13.8 0.0 1.6 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain Tudor-knot PF11717.6 001301263.1_21029001_3 - 0.45 10.3 4.1 0.49 10.2 2.1 2.1 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain Sec34 PF04136.13 001301154.1_21029001_3 - 2e-53 180.1 7.1 2e-53 180.1 7.1 3.5 5 0 0 5 5 5 2 Sec34-like family Lig_chan PF00060.24 001185087.3_21029001_2 - 1.9e-59 199.7 0.1 3.3e-59 198.9 0.1 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel ANF_receptor PF01094.26 001185087.3_21029001_2 - 5.8e-59 199.8 0.1 9.2e-59 199.2 0.1 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan-Glu_bd PF10613.7 001185087.3_21029001_2 - 3.2e-45 152.9 0.1 5.8e-45 152.0 0.1 1.4 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 001185087.3_21029001_2 - 1e-23 83.8 0.0 1.7e-23 83.1 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 KIAA1430 PF13879.4 001309158.1_21029001_1 - 2.4e-16 60.2 4.0 2.4e-16 60.2 4.0 2.5 3 0 0 3 3 3 1 KIAA1430 homologue DUF59 PF01883.17 001242528.1_21022001_2 - 6e-16 58.3 0.1 1.1e-15 57.4 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function DUF59 GRIN_C PF15235.4 001257132.1_21025001_1 - 2.3e-50 170.1 1.5 7.3e-50 168.5 1.5 1.9 1 0 0 1 1 1 1 G protein-regulated inducer of neurite outgrowth C-terminus zf-H2C2_2 PF13465.4 001256927.1_21024001_1 - 2.7e-71 232.9 59.6 3e-09 36.8 1.5 11.3 11 0 0 11 11 11 10 Zinc-finger double domain zf-C2H2 PF00096.24 001256927.1_21024001_1 - 4.2e-53 174.8 60.7 1.7e-07 31.2 0.4 10.4 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001256927.1_21024001_1 - 1.4e-32 109.4 61.4 0.00025 21.5 0.3 10.3 10 0 0 10 10 10 10 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001256927.1_21024001_1 - 7.9e-14 51.0 42.3 0.039 13.6 1.0 9.3 10 0 0 10 10 9 7 zinc-finger C2H2-type zf-C2H2_jaz PF12171.6 001256927.1_21024001_1 - 9.3e-13 48.0 14.1 0.81 10.0 0.0 8.9 10 0 0 10 10 10 5 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 001256927.1_21024001_1 - 4e-07 29.9 43.4 0.041 13.9 1.1 7.3 5 2 3 8 8 8 5 Zinc ribbon domain zf-C2H2_8 PF15909.3 001256927.1_21024001_1 - 0.00016 21.7 28.6 0.097 12.9 2.9 4.8 1 1 3 4 4 4 3 C2H2-type zinc ribbon zf-Di19 PF05605.10 001256927.1_21024001_1 - 0.00027 21.0 42.0 0.21 11.8 5.5 6.5 4 2 1 6 6 6 5 Drought induced 19 protein (Di19), zinc-binding zf-LYAR PF08790.9 001256927.1_21024001_1 - 0.0006 19.5 18.3 6.2 6.7 0.2 7.4 8 0 0 8 8 8 1 LYAR-type C2HC zinc finger zf-C2H2_6 PF13912.4 001256927.1_21024001_1 - 0.00084 19.1 43.9 0.23 11.3 0.1 9.9 10 0 0 10 10 10 3 C2H2-type zinc finger zinc_ribbon_15 PF17032.3 001256927.1_21024001_1 - 0.0026 18.3 23.0 1.1 9.9 1.8 5.6 1 1 5 7 7 7 2 zinc-ribbon family HypA PF01155.17 001256927.1_21024001_1 - 0.02 14.7 23.8 2.4 8.1 2.1 5.4 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF3268 PF11672.6 001256927.1_21024001_1 - 0.06 13.6 18.8 0.16 12.2 0.4 5.4 3 2 3 6 6 6 0 zinc-finger-containing domain BolA PF01722.16 001256927.1_21024001_1 - 0.069 13.3 8.1 5.3 7.3 0.2 4.5 4 1 1 5 5 5 0 BolA-like protein C1_4 PF07975.10 001256927.1_21024001_1 - 0.085 13.0 29.4 0.79 9.9 0.1 6.9 1 1 7 9 9 9 0 TFIIH C1-like domain zf-met PF12874.5 001256927.1_21024001_1 - 0.14 12.5 0.1 0.14 12.5 0.1 8.8 9 0 0 9 9 9 0 Zinc-finger of C2H2 type zinc_ribbon_9 PF14369.4 001256927.1_21024001_1 - 0.36 11.0 0.1 0.36 11.0 0.1 8.2 8 1 1 9 9 9 0 zinc-ribbon SprT-like PF10263.7 001256927.1_21024001_1 - 0.53 10.0 36.7 1.4 8.6 6.7 5.5 1 1 3 4 4 4 0 SprT-like family FYDLN_acid PF09538.8 001256927.1_21024001_1 - 0.67 10.5 28.1 34 5.1 0.4 8.5 2 1 7 9 9 9 0 Protein of unknown function (FYDLN_acid) zf-H2C2_5 PF13909.4 001256927.1_21024001_1 - 2.5 7.8 53.8 0.049 13.3 3.4 9.4 10 1 0 10 10 9 0 C2H2-type zinc-finger domain SH3_9 PF14604.4 001206539.1_06529001_3 - 3.5e-45 151.5 3.6 1.3e-14 53.7 0.1 3.5 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.26 001206539.1_06529001_3 - 3.9e-40 135.1 5.2 6.7e-14 51.1 0.2 3.4 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.15 001206539.1_06529001_3 - 1.3e-35 120.7 3.8 1.3e-12 47.1 0.1 3.7 3 0 0 3 3 3 3 Variant SH3 domain Ets PF00178.20 198381.1_26225001_3 - 2.6e-29 101.4 0.4 5.5e-29 100.3 0.4 1.6 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.14 198381.1_26225001_3 - 2.9e-28 97.5 0.9 5.2e-28 96.7 0.9 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain TBD PF12845.5 001355268.1_32925001_1 - 7.3e-24 83.3 0.1 1.4e-23 82.4 0.1 1.4 1 0 0 1 1 1 1 TBD domain UPF0242 PF06785.9 001355268.1_32925001_3 - 0.073 11.6 2.8 0.11 11.1 2.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) PHD PF00628.27 001101802.1_26229001_1 - 1.4e-11 44.0 6.2 1.4e-11 44.0 6.2 2.4 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.4 001101802.1_26229001_1 - 0.011 15.2 0.8 0.034 13.5 0.8 2.0 1 0 0 1 1 1 0 PHD-finger C1_1 PF00130.20 001101802.1_26229001_1 - 0.027 14.2 9.1 0.02 14.7 2.0 4.0 4 0 0 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) AT_hook PF02178.17 001101802.1_26229001_1 - 0.053 13.3 2.2 0.19 11.6 2.2 2.0 1 0 0 1 1 1 0 AT hook motif Zf_RING PF16744.3 001101802.1_26229001_1 - 0.11 12.4 3.7 0.47 10.5 3.7 2.1 1 0 0 1 1 1 0 KIAA1045 RING finger Seryl_tRNA_N PF02403.20 001101802.1_26229001_1 - 3.3 7.8 19.7 4.1 7.6 4.2 2.5 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ERM PF00769.17 001082122.1_37925001_1 - 4.7e-68 229.5 41.0 4.7e-68 229.5 41.0 2.1 1 1 1 2 2 2 1 Ezrin/radixin/moesin family FERM_C PF09380.8 001082122.1_37925001_1 - 4.9e-28 97.2 0.0 1.2e-27 96.0 0.0 1.7 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.16 001082122.1_37925001_1 - 1.1e-26 93.5 0.2 1.1e-26 93.5 0.2 3.1 2 1 0 2 2 2 1 FERM central domain FERM_N PF09379.8 001082122.1_37925001_1 - 1.4e-14 53.7 0.2 5e-14 51.9 0.0 2.0 2 0 0 2 2 2 1 FERM N-terminal domain zf-H2C2_2 PF13465.4 001177718.1_26229001_1 - 2.1e-12 46.7 8.7 2.6e-07 30.6 1.4 5.3 6 0 0 6 6 6 2 Zinc-finger double domain zf-C2H2 PF00096.24 001177718.1_26229001_1 - 3.4e-11 42.8 28.9 8e-05 22.8 2.7 4.7 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 001177718.1_26229001_1 - 0.0049 16.6 0.6 0.0049 16.6 0.6 3.1 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_8 PF15909.3 001177718.1_26229001_1 - 0.0057 16.8 5.6 0.013 15.6 5.6 1.6 1 0 0 1 1 1 1 C2H2-type zinc ribbon zf-C2H2_4 PF13894.4 001177718.1_26229001_1 - 0.0058 17.2 1.8 0.0058 17.2 1.8 5.8 7 0 0 7 7 7 3 C2H2-type zinc finger FOXP-CC PF16159.3 001177718.1_26229001_1 - 0.015 15.8 5.5 4.5 7.8 0.3 3.5 1 1 2 3 3 3 0 FOXP coiled-coil domain zf-Di19 PF05605.10 001177718.1_26229001_1 - 0.69 10.1 11.5 0.022 14.9 1.4 3.4 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.6 001177718.1_26229001_1 - 3.6 7.9 10.8 18 5.7 0.2 4.0 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 001177718.1_26229001_1 - 6.2 7.2 14.9 0.77 10.1 0.4 4.3 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-DHHC PF01529.18 175160.4_32925001_3 - 2.5e-36 124.6 10.7 2.5e-36 124.6 10.7 1.5 2 0 0 2 2 2 1 DHHC palmitoyltransferase Virul_fac_BrkB PF03631.13 175160.4_32925001_3 - 3.7 7.0 13.9 0.052 13.0 1.1 2.3 2 1 0 2 2 2 0 Virulence factor BrkB CUE PF02845.14 126511.1_26224120_3 - 1.4e-09 37.3 0.0 2.4e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 CUE domain dNK PF01712.17 134896.1_26222120_3 - 2.8e-16 59.9 2.4 1.6e-10 41.1 0.1 2.0 1 1 1 2 2 2 2 Deoxynucleoside kinase HIT PF01230.21 134494.1_26223120_3 - 1.9e-27 95.7 2.2 1e-13 51.7 0.1 2.2 2 0 0 2 2 2 2 HIT domain DcpS_C PF11969.6 134494.1_26223120_3 - 2.6e-16 60.0 3.9 2.8e-11 43.7 0.3 2.2 2 0 0 2 2 2 2 Scavenger mRNA decapping enzyme C-term binding Peptidase_S10 PF00450.20 133656.1_26227120_1 - 3.7e-71 240.6 2.4 4.8e-71 240.2 2.4 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Peptidase_S10 PF00450.20 133656.1_26227120_2 - 8.4e-58 196.6 0.0 1e-57 196.3 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase ABC_membrane_2 PF06472.13 148470.1_26227120_1 - 8.8e-61 205.6 0.6 1.2e-60 205.1 0.6 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 IRK PF01007.18 148470.1_26227120_1 - 0.083 11.7 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 Inward rectifier potassium channel ABC_tran PF00005.25 148470.1_26227120_2 - 8.3e-07 29.5 0.4 1.3e-06 28.9 0.4 1.2 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.4 148470.1_26227120_2 - 0.022 15.0 0.3 0.039 14.2 0.3 1.3 1 0 0 1 1 1 0 AAA ATPase domain T2SSE PF00437.18 148470.1_26227120_2 - 0.051 12.5 0.2 0.076 11.9 0.2 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.4 148470.1_26227120_2 - 0.062 12.9 0.1 0.1 12.2 0.1 1.2 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.4 148470.1_26227120_2 - 0.15 12.2 0.6 0.28 11.3 0.6 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.4 148470.1_26227120_2 - 0.16 11.6 1.0 0.32 10.6 1.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.4 148470.1_26227120_2 - 0.19 12.1 0.6 0.29 11.5 0.6 1.1 1 0 0 1 1 1 0 AAA domain ABC_membrane_2 PF06472.13 148470.1_26227120_3 - 4.9e-05 22.7 0.7 6.4e-05 22.3 0.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.25 148470.1_26227120_3 - 0.00025 21.4 0.0 0.00045 20.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter RRM_1 PF00076.20 028477.1_26225120_1 - 0.00061 19.4 0.0 0.0011 18.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 028477.1_26225120_1 - 0.056 13.4 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif RBM1CTR PF08081.9 028477.1_26225120_3 - 1.6e-22 79.1 14.1 1.6e-22 79.1 14.1 8.7 5 2 3 8 8 8 1 RBM1CTR (NUC064) family RRM_1 PF00076.20 028477.1_26225120_3 - 2.6e-11 43.1 0.1 4.9e-11 42.2 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SNF2_N PF00176.21 045644.1_26229120_3 - 1.2e-60 205.0 0.9 2e-60 204.2 0.9 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.29 045644.1_26229120_3 - 1.1e-17 64.3 0.1 8.3e-17 61.4 0.1 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.13 045644.1_26229120_3 - 5e-10 39.5 0.0 2e-09 37.5 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.3 045644.1_26229120_3 - 2.8e-06 26.6 0.3 7.4e-06 25.2 0.2 1.7 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase CUE PF02845.14 045644.1_26229120_3 - 0.00028 20.4 0.1 0.086 12.4 0.0 2.6 2 0 0 2 2 2 2 CUE domain Pox_D5 PF03288.14 045644.1_26229120_3 - 0.013 15.8 2.5 0.045 14.1 2.5 1.9 1 0 0 1 1 1 0 Poxvirus D5 protein-like Il2rg PF15874.3 033212.1_26222120_1 - 1.8e-16 59.9 0.0 2.8e-16 59.3 0.0 1.3 1 0 0 1 1 1 1 Putative Interleukin 2 receptor, gamma chain Il2rg PF15874.3 033212.1_26222120_2 - 2.9e-09 36.8 0.3 4.8e-09 36.1 0.3 1.3 1 0 0 1 1 1 1 Putative Interleukin 2 receptor, gamma chain Acetyltransf_16 PF05301.9 075072.1_06523120_3 - 3.1e-76 254.8 0.0 4e-76 254.5 0.0 1.1 1 0 0 1 1 1 1 GNAT acetyltransferase, Mec-17 Acetyltransf_7 PF13508.5 075072.1_06523120_3 - 0.0067 16.7 0.0 0.013 15.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.23 075072.1_06523120_3 - 0.016 15.3 0.0 0.027 14.6 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.5 075072.1_06523120_3 - 0.062 13.1 0.1 0.13 12.1 0.1 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Ldh_1_N PF00056.21 135204.1_06524120_2 - 1.1e-08 35.1 0.0 1.8e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 135204.1_06524120_3 - 5e-45 153.3 0.0 6.4e-45 152.9 0.0 1.1 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.21 135204.1_06524120_3 - 0.032 14.2 0.2 0.058 13.4 0.2 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Abhydrolase_1 PF00561.18 132766.1_06524120_3 - 9.3e-21 74.5 0.0 1.3e-20 74.0 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 132766.1_06524120_3 - 2.6e-13 50.9 0.0 4.3e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 132766.1_06524120_3 - 4.1e-08 32.7 0.0 5.7e-08 32.2 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.12 132766.1_06524120_3 - 0.0089 14.6 0.0 0.012 14.1 0.0 1.1 1 0 0 1 1 1 1 Ndr family PGAP1 PF07819.11 132766.1_06524120_3 - 0.017 14.7 0.0 0.027 14.1 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein DnaJ PF00226.29 120605.1_06529120_3 - 2.5e-26 91.5 2.7 3.6e-26 90.9 2.7 1.2 1 0 0 1 1 1 1 DnaJ domain PAS_11 PF14598.4 110397.1_06527120_1 - 1.6e-25 89.3 0.2 6e-22 77.8 0.1 2.3 2 0 0 2 2 2 2 PAS domain PAS PF00989.23 110397.1_06527120_1 - 3.1e-20 72.1 0.0 5.3e-09 35.9 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_3 PF08447.10 110397.1_06527120_1 - 3.1e-19 68.9 0.0 2.1e-11 43.8 0.0 2.3 2 0 0 2 2 2 2 PAS fold HLH PF00010.24 110397.1_06527120_1 - 5.7e-17 61.3 0.8 1.1e-16 60.3 0.8 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.5 110397.1_06527120_1 - 4.2e-08 33.3 0.0 9.5e-05 22.5 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.8 110397.1_06527120_1 - 0.00031 20.8 0.0 0.06 13.5 0.0 2.5 2 0 0 2 2 2 1 PAS fold PAS_2 PF08446.9 110397.1_06527120_1 - 0.054 14.0 0.0 0.17 12.4 0.0 1.8 2 0 0 2 2 2 0 PAS fold KRTDAP PF15200.4 130912.1_06521120_1 - 2e-05 24.1 0.3 0.0013 18.3 0.0 2.3 1 1 1 2 2 2 2 Keratinocyte differentiation-associated tRNA_Me_trans PF03054.14 028029.1_06523120_1 - 5.6e-60 202.9 0.0 7.2e-60 202.5 0.0 1.1 1 0 0 1 1 1 1 tRNA methyl transferase ThiI PF02568.12 028029.1_06523120_1 - 3.6e-06 26.6 0.0 4.9e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) NAD_synthase PF02540.15 028029.1_06523120_1 - 0.00077 18.5 0.0 0.0011 18.0 0.0 1.2 1 0 0 1 1 1 1 NAD synthase QueC PF06508.11 028029.1_06523120_1 - 0.056 12.8 0.0 0.079 12.3 0.0 1.2 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.14 028029.1_06523120_2 - 6.3e-69 232.3 0.0 8e-69 232.0 0.0 1.1 1 0 0 1 1 1 1 tRNA methyl transferase Neugrin PF06413.9 028054.1_06524120_3 - 2.3e-95 318.8 0.0 3e-95 318.4 0.0 1.1 1 0 0 1 1 1 1 Neugrin MRP-L20 PF12824.5 028054.1_06524120_3 - 0.0037 17.3 0.1 0.006 16.6 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 WD40 PF00400.30 073586.1_06525120_3 - 5.4e-09 36.4 3.1 1.9 9.3 0.1 6.7 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 073586.1_06525120_3 - 0.00059 19.9 0.1 2.8 8.2 0.0 4.1 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Sep15_SelM PF08806.9 144761.1_06522120_2 - 8.3e-21 73.9 0.1 1.2e-20 73.3 0.1 1.2 1 0 0 1 1 1 1 Sep15/SelM redox domain Collagen PF01391.16 103815.1_06525120_3 - 1e-18 66.7 122.4 8.8e-10 38.1 31.9 7.5 4 3 1 5 5 5 3 Collagen triple helix repeat (20 copies) EMI PF07546.11 103815.1_06525120_3 - 8.7e-15 55.1 11.4 1.4e-14 54.4 11.4 1.3 1 0 0 1 1 1 1 EMI domain Ribosomal_S27e PF01667.15 024614.1_06523120_2 - 1.4e-29 101.4 5.1 2.8e-29 100.4 5.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S27 SUZ PF12752.5 102346.1_06522120_2 - 7.1e-13 49.0 0.1 7.1e-13 49.0 0.1 2.7 3 0 0 3 3 3 1 SUZ domain SUZ-C PF12901.5 102346.1_06522120_2 - 8.7e-10 38.3 3.0 1.8e-09 37.3 3.0 1.6 1 0 0 1 1 1 1 SUZ-C motif SelK_SelG PF10961.6 144938.1_06522120_3 - 1.7e-08 34.8 1.3 2.8e-08 34.1 1.3 1.3 1 0 0 1 1 1 1 Selenoprotein SelK_SelG Ribosomal_S27e PF01667.15 024613.1_06523120_2 - 1.6e-29 101.2 5.1 3.2e-29 100.2 5.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S27 GSHPx PF00255.17 138142.1_06523120_2 - 6.3e-27 93.2 0.2 9.5e-27 92.6 0.2 1.2 1 0 0 1 1 1 1 Glutathione peroxidase Iso_dh PF00180.18 030768.1_06523120_2 - 1.8e-75 254.1 0.8 2e-75 254.0 0.2 1.4 2 0 0 2 2 2 1 Isocitrate/isopropylmalate dehydrogenase AAA_3 PF07726.9 030768.1_06523120_2 - 0.024 14.3 0.0 0.041 13.6 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rdx PF10262.7 146805.1_06527120_1 - 1.3e-09 38.0 0.0 2.1e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Rdx family DUF3791 PF12668.5 103807.1_06525120_1 - 0.026 14.4 0.1 0.087 12.7 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3791) Helicase_C PF00271.29 103807.1_06525120_2 - 2.9e-30 104.8 0.1 5.3e-30 103.9 0.1 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.27 103807.1_06525120_2 - 2.3e-12 46.9 0.0 5.5e-12 45.7 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase DEAD PF00270.27 103807.1_06525120_3 - 3.4e-20 72.4 0.0 5.5e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.13 103807.1_06525120_3 - 0.13 12.1 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Endonuc-EcoRV PF09233.9 045536.1_06523120_2 - 0.0063 15.8 0.2 0.009 15.3 0.2 1.1 1 0 0 1 1 1 1 Restriction endonuclease EcoRV PIG-H PF10181.7 045138.1_06523120_3 - 1.1e-19 70.0 0.2 1.6e-19 69.4 0.2 1.3 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component PLU-1 PF08429.9 148673.1_26229120_3 - 1.9e-92 309.9 1.7 1.6e-88 296.9 0.8 2.5 2 0 0 2 2 2 2 PLU-1-like protein JmjC PF02373.20 148673.1_26229120_3 - 2e-43 147.4 0.7 3.5e-43 146.6 0.7 1.4 1 0 0 1 1 1 1 JmjC domain, hydroxylase ARID PF01388.19 148673.1_26229120_3 - 3.1e-17 62.9 0.0 6.5e-17 61.8 0.0 1.6 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.15 148673.1_26229120_3 - 4.8e-16 58.3 0.4 1.2e-15 57.1 0.4 1.7 1 0 0 1 1 1 1 jmjN domain zf-C5HC2 PF02928.14 148673.1_26229120_3 - 1.1e-15 57.6 11.2 1.1e-15 57.6 11.2 2.4 2 0 0 2 2 2 1 C5HC2 zinc finger PHD PF00628.27 148673.1_26229120_3 - 1.8e-15 56.4 12.5 6.1e-12 45.1 3.5 3.0 3 0 0 3 3 3 2 PHD-finger Zf_RING PF16744.3 148673.1_26229120_3 - 0.026 14.5 3.5 1.4 8.9 0.1 2.9 2 0 0 2 2 2 0 KIAA1045 RING finger PHD_4 PF16866.3 148673.1_26229120_3 - 2.6 8.1 8.8 14 5.7 3.0 3.1 2 0 0 2 2 2 0 PHD-finger FYVE_2 PF02318.14 148673.1_26229120_3 - 4.3 7.4 14.2 0.91 9.6 0.8 3.6 3 0 0 3 3 3 0 FYVE-type zinc finger UFD1 PF03152.12 028403.1_32924120_3 - 1.4e-70 236.1 0.1 2e-70 235.6 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 ADH_zinc_N PF00107.24 151492.1_26229120_1 - 0.0011 18.8 0.0 0.013 15.3 0.0 2.1 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Sec16_C PF12931.5 151492.1_26229120_2 - 1.9e-24 86.7 0.0 3.7e-24 85.8 0.0 1.4 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.5 151492.1_26229120_2 - 5.7e-06 26.8 0.0 1.2e-05 25.8 0.0 1.6 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region DHHA2 PF02833.12 130131.1_26226120_2 - 2.5e-24 85.9 0.0 4e-24 85.3 0.0 1.3 1 0 0 1 1 1 1 DHHA2 domain Calpain_inhib PF00748.17 130131.1_26226120_2 - 0.15 12.4 0.9 2.2 8.6 0.3 2.3 2 0 0 2 2 2 0 Calpain inhibitor TBD PF12845.5 149324.1_32925120_3 - 2.2e-21 75.3 1.4 2.1e-16 59.4 0.0 2.7 2 0 0 2 2 2 2 TBD domain DUF5082 PF16888.3 149324.1_32925120_3 - 0.0091 16.2 1.1 0.018 15.3 1.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5082) UPF0242 PF06785.9 149324.1_32925120_3 - 0.16 10.5 2.3 0.24 9.9 2.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) OEP PF02321.16 149324.1_32925120_3 - 0.59 9.8 6.4 0.94 9.1 6.4 1.2 1 0 0 1 1 1 0 Outer membrane efflux protein IncA PF04156.12 149324.1_32925120_3 - 4.9 6.8 9.7 6.2 6.4 8.7 1.6 1 1 0 1 1 1 0 IncA protein Jnk-SapK_ap_N PF09744.7 149324.1_32925120_3 - 5.6 7.0 10.2 2 8.5 2.7 2.4 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 TBD PF12845.5 149323.1_32928120_1 - 5.8e-25 86.8 0.3 1.2e-24 85.8 0.3 1.6 1 0 0 1 1 1 1 TBD domain UPF0242 PF06785.9 149323.1_32928120_1 - 0.14 10.8 2.8 0.2 10.2 2.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) PPARgamma_N PF12577.6 003097.1_06527120_1 - 1.4e-31 108.9 1.4 3.2e-31 107.7 1.4 1.7 1 0 0 1 1 1 1 PPAR gamma N-terminal region zf-C4 PF00105.16 003097.1_06527120_1 - 4.2e-27 94.3 15.0 7.2e-27 93.5 15.0 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) tRNA_int_endo PF01974.15 003097.1_06527120_1 - 4.7e-20 71.3 0.0 2.3e-19 69.1 0.0 2.1 2 0 0 2 2 2 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.12 003097.1_06527120_1 - 5.6e-17 61.0 0.3 1.5e-12 46.8 0.1 2.5 2 0 0 2 2 2 2 tRNA intron endonuclease, N-terminal domain Hormone_recep PF00104.28 003097.1_06527120_1 - 8.1e-08 32.0 0.0 2.1e-07 30.6 0.0 1.7 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Tmemb_55A PF09788.7 003097.1_06527120_1 - 0.057 12.4 3.2 0.094 11.6 3.2 1.2 1 0 0 1 1 1 0 Transmembrane protein 55A p450 PF00067.20 003052.2_06523120_1 - 0.12 10.9 0.0 0.17 10.5 0.0 1.1 1 0 0 1 1 1 0 Cytochrome P450 p450 PF00067.20 003052.2_06523120_2 - 9.2e-30 103.6 0.6 1.8e-29 102.7 0.6 1.4 1 1 0 1 1 1 1 Cytochrome P450 PPARgamma_N PF12577.6 003096.1_06526120_1 - 1.2e-31 109.0 1.4 3e-31 107.8 1.4 1.7 1 0 0 1 1 1 1 PPAR gamma N-terminal region zf-C4 PF00105.16 003096.1_06526120_1 - 3.9e-27 94.4 15.0 6.6e-27 93.6 15.0 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) tRNA_int_endo PF01974.15 003096.1_06526120_1 - 4.1e-20 71.5 0.0 2.1e-19 69.2 0.0 2.1 2 0 0 2 2 2 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.12 003096.1_06526120_1 - 4.8e-17 61.2 0.3 1.4e-12 46.9 0.1 2.5 2 0 0 2 2 2 2 tRNA intron endonuclease, N-terminal domain Hormone_recep PF00104.28 003096.1_06526120_1 - 4.9e-08 32.7 0.0 1.3e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Tmemb_55A PF09788.7 003096.1_06526120_1 - 0.052 12.5 3.2 0.087 11.8 3.2 1.2 1 0 0 1 1 1 0 Transmembrane protein 55A FixQ PF05545.9 038187.1_06521120_3 - 0.082 12.7 0.2 0.18 11.7 0.2 1.6 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ NEP PF10167.7 027315.1_06524120_1 - 1.2e-39 134.6 0.1 1.2e-39 134.6 0.1 1.7 2 0 0 2 2 2 1 Uncharacterised conserved protein SRF-TF PF00319.16 027315.1_06524120_1 - 2.4e-23 81.2 0.3 4.9e-23 80.2 0.3 1.6 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) SR-25 PF10500.7 027315.1_06524120_1 - 0.0038 16.7 18.3 0.0056 16.2 18.3 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF4604 PF15377.4 027315.1_06524120_2 - 0.056 13.8 13.8 0.08 13.2 13.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) AP3D1 PF06375.9 027315.1_06524120_2 - 1.4 9.0 19.0 2 8.6 19.0 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF4604 PF15377.4 027315.1_06524120_3 - 0.012 15.9 10.9 0.022 15.1 10.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) DUF4730 PF15873.3 046270.1_06523120_3 - 1.3e-25 89.2 6.9 1.3e-25 89.2 6.9 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4730) OST3_OST6 PF04756.11 045130.2_06524120_1 - 2.4e-77 260.1 8.1 3.6e-77 259.5 8.1 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin PF00085.18 045130.2_06524120_1 - 0.0028 17.4 0.0 0.0058 16.4 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Wzy_C PF04932.13 045130.2_06524120_1 - 3.1 7.3 6.8 77 2.8 6.8 2.4 1 1 0 1 1 1 0 O-Antigen ligase TctB PF07331.9 045130.2_06524120_1 - 9.6 6.3 10.4 43 4.3 10.4 2.1 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family RNA_polI_A34 PF08208.9 045130.2_06524120_2 - 5.8 6.8 23.6 7.4 6.5 23.6 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF4604 PF15377.4 045130.2_06524120_3 - 0.5 10.7 17.2 0.69 10.2 17.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) MIF4G PF02854.17 044990.1_06524120_1 - 4.3e-35 121.2 0.2 5.5e-35 120.8 0.2 1.1 1 0 0 1 1 1 1 MIF4G domain PAM2 PF07145.13 044990.1_06524120_1 - 3.3e-05 23.1 0.1 9.2e-05 21.7 0.1 1.8 1 0 0 1 1 1 1 Ataxin-2 C-terminal region ig PF00047.23 036568.1_21023120_2 - 3.8e-11 42.9 0.1 0.00018 21.5 0.3 2.7 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 036568.1_21023120_2 - 4.3e-05 23.7 0.0 0.037 14.2 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 036568.1_21023120_2 - 0.00011 22.6 0.1 0.051 14.1 0.1 3.1 2 1 0 2 2 2 1 Immunoglobulin domain V-set PF07686.15 036568.1_21023120_2 - 0.00063 19.7 0.1 14 5.8 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin V-set domain DUF4721 PF15848.3 036568.1_21023120_3 - 1.3 9.4 7.6 6.2 7.2 0.4 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4721) UPF0730 PF15827.3 038117.1_06527120_2 - 1.3e-13 50.8 3.3 2.2e-13 50.0 3.3 1.4 1 0 0 1 1 1 1 UPF0730 unknown protein family SERTA PF06031.11 038117.1_06527120_2 - 2.2e-13 49.5 3.1 5.9e-13 48.1 2.8 1.9 2 0 0 2 2 2 1 SERTA motif Ribosomal_S6e PF01092.17 038138.1_06523120_1 - 3.5e-05 23.6 0.0 6.8e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S6e Ribosomal_S6e PF01092.17 038138.1_06523120_3 - 4e-26 91.3 0.2 1.6e-25 89.3 0.2 1.9 1 1 0 1 1 1 1 Ribosomal protein S6e MHC_I PF00129.16 036560.1_21023120_1 - 2e-18 66.4 0.0 2.8e-18 66.0 0.0 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 036560.1_21023120_3 - 1e-11 45.0 0.0 1.8e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I PF00129.16 036560.1_21023120_3 - 9.5e-11 41.4 0.0 1.2e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 BiPBP_C PF06832.10 036560.1_21023120_3 - 0.019 14.8 0.0 0.071 13.0 0.0 1.9 2 0 0 2 2 2 0 Penicillin-Binding Protein C-terminus Family Ig_2 PF13895.4 036566.2_21023120_1 - 0.047 13.9 0.0 0.1 12.8 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain DUF4721 PF15848.3 036566.2_21023120_1 - 0.048 14.0 2.3 6.9 7.0 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4721) ig PF00047.23 036566.2_21023120_3 - 2.3e-13 50.0 0.0 3.4e-06 27.0 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 036566.2_21023120_3 - 3.2e-07 30.7 0.0 0.00025 21.5 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 036566.2_21023120_3 - 3.7e-06 27.0 0.0 0.021 15.0 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 036566.2_21023120_3 - 0.00014 21.8 1.3 4.6 7.3 0.0 3.2 2 1 0 3 3 3 2 Immunoglobulin V-set domain ig PF00047.23 036567.1_21022120_2 - 3.7e-05 23.7 0.3 0.00012 22.1 0.3 1.9 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 036567.1_21022120_2 - 0.0037 17.7 0.2 0.036 14.6 0.2 2.3 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 036567.1_21022120_2 - 0.0095 16.1 0.1 0.024 14.9 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.15 036567.1_21022120_2 - 0.066 13.2 0.6 10 6.2 0.0 2.6 3 0 0 3 3 3 0 Immunoglobulin V-set domain GP38 PF05268.9 046265.1_06524120_1 - 3.1 7.3 7.3 5 6.6 7.3 1.2 1 0 0 1 1 1 0 Phage tail fibre adhesin Gp38 KAAG1 PF15354.4 045655.1_06522120_1 - 9.7 6.7 11.8 32 5.0 9.8 2.1 1 1 1 2 2 2 0 Kidney-associated antigen 1 PH PF00169.27 001357425.1_32927001_1 - 1.8e-08 34.7 0.3 2.9e-08 34.0 0.3 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 001357425.1_32927001_1 - 0.015 15.6 0.0 0.026 14.8 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain Copine PF07002.14 001357439.1_32928001_2 - 5.8e-95 316.7 0.0 7.8e-95 316.3 0.0 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.28 001357439.1_32928001_2 - 1.4e-25 89.5 0.1 5.2e-12 45.8 0.1 2.3 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.7 001357439.1_32928001_2 - 9.9e-05 22.4 0.0 0.00017 21.6 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.26 001357439.1_32928001_2 - 0.0022 18.1 0.0 0.004 17.3 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Fz PF01392.20 001243330.1_49825001_3 - 7.1e-29 100.6 3.8 7.1e-29 100.6 3.8 1.7 2 0 0 2 2 2 1 Fz domain NTR PF01759.19 001243330.1_49825001_3 - 4e-21 74.7 0.6 4e-21 74.7 0.6 1.6 1 1 1 2 2 2 1 UNC-6/NTR/C345C module Fz PF01392.20 001131231.1_43525001_3 - 6.8e-29 100.7 3.9 6.8e-29 100.7 3.9 1.6 2 0 0 2 2 2 1 Fz domain NTR PF01759.19 001131231.1_43525001_3 - 1.5e-21 76.0 1.5 1.7e-21 75.9 0.5 1.6 1 1 1 2 2 2 1 UNC-6/NTR/C345C module APOBEC_N PF08210.9 001346001.1_40424001_2 - 1.2e-101 337.8 6.7 4.1e-51 173.3 2.2 2.1 2 0 0 2 2 2 2 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001346001.1_40424001_2 - 1.8e-62 207.1 1.0 3.2e-30 103.7 0.0 2.4 2 0 0 2 2 2 2 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 001346001.1_40424001_2 - 0.00038 20.1 0.0 0.0077 16.0 0.0 2.2 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region SAA PF00277.16 001357495.1_29722001_1 - 2.1e-39 134.0 0.2 3e-39 133.5 0.2 1.2 1 0 0 1 1 1 1 Serum amyloid A protein SAA PF00277.16 001357496.1_29722001_1 - 3.3e-51 171.9 2.1 4.2e-51 171.6 2.1 1.1 1 0 0 1 1 1 1 Serum amyloid A protein DUF1049 PF06305.9 132745.2_39722120_3 - 0.0023 17.6 0.5 0.004 16.8 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1049) DUF1049 PF06305.9 132744.1_06521120_3 - 0.0017 18.0 0.2 0.0026 17.4 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1049) Connexin PF00029.17 001009780.1_39522001_2 - 2.7e-86 288.9 8.1 3.6e-86 288.5 8.1 1.2 1 0 0 1 1 1 1 Connexin Bac_export_2 PF01312.17 001009780.1_39522001_2 - 3.6 6.6 5.6 0.78 8.7 1.1 2.1 1 1 1 2 2 2 0 FlhB HrpN YscU SpaS Family 7tm_1 PF00001.19 001009119.1_39722001_1 - 1.8e-34 119.1 32.7 8.9e-33 113.5 32.7 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001009119.1_39722001_1 - 3e-13 50.0 9.5 3e-13 50.0 9.5 2.5 1 1 1 2 2 2 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001009119.1_39722001_1 - 9.9e-08 31.5 30.9 1.5e-07 30.9 30.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001009119.1_39722001_1 - 0.42 9.8 33.1 0.0056 15.9 18.3 2.5 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx PI-PLC-X PF00388.17 214350.1_49825001_3 - 4.7e-59 198.0 0.0 7.9e-59 197.3 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.17 214350.1_49825001_3 - 3.7e-40 136.7 0.1 7.5e-40 135.7 0.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.9 214350.1_49825001_3 - 4.1e-18 65.5 0.5 1.5e-17 63.7 0.5 2.0 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.28 214350.1_49825001_3 - 4.9e-14 52.3 0.0 1.3e-13 51.0 0.0 1.7 1 0 0 1 1 1 1 C2 domain EF-hand_10 PF14788.4 214350.1_49825001_3 - 0.0023 17.6 0.3 0.0053 16.5 0.3 1.7 1 0 0 1 1 1 1 EF hand HSP90 PF00183.16 214103.1_49826001_1 - 2.1e-230 765.8 28.0 2.1e-230 765.8 28.0 1.7 1 1 1 2 2 2 1 Hsp90 protein HATPase_c PF02518.24 214103.1_49826001_1 - 9.1e-14 51.8 0.3 1.6e-13 51.1 0.3 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.4 214103.1_49826001_1 - 4.5e-11 42.6 0.4 1.1e-10 41.3 0.4 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF913 PF06025.10 214103.1_49826001_1 - 4 6.2 10.6 2.2 7.0 1.3 2.8 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) EF1_GNE PF00736.17 001009449.1_39522001_1 - 6e-27 93.5 0.0 1.9e-26 91.9 0.0 1.9 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.7 001009449.1_39522001_1 - 5.5e-12 45.8 8.9 5.5e-12 45.8 8.9 2.6 2 0 0 2 2 1 1 Eukaryotic elongation factor 1 beta central acidic region Striatin PF08232.10 001009449.1_39522001_1 - 0.0005 20.5 3.8 0.00098 19.6 3.8 1.4 1 0 0 1 1 1 1 Striatin family JIP_LZII PF16471.3 001009449.1_39522001_1 - 0.0034 17.4 0.6 0.0095 16.0 0.6 1.7 1 0 0 1 1 1 1 JNK-interacting protein leucine zipper II CCD48 PF15799.3 001009449.1_39522001_1 - 0.0035 15.7 4.4 0.0058 15.0 4.4 1.3 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 48 TolA_bind_tri PF16331.3 001009449.1_39522001_1 - 0.0085 16.0 0.9 0.025 14.5 0.4 2.0 2 1 0 2 2 2 1 TolA binding protein trimerisation Trimer_CC PF08954.9 001009449.1_39522001_1 - 0.011 15.2 0.1 0.088 12.2 0.0 2.6 2 0 0 2 2 2 0 Trimerisation motif KASH_CCD PF14662.4 001009449.1_39522001_1 - 0.019 14.7 1.9 0.031 14.0 1.8 1.4 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Reo_sigmaC PF04582.10 001009449.1_39522001_1 - 0.02 14.2 0.1 0.027 13.8 0.1 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein TSC22 PF01166.16 001009449.1_39522001_1 - 0.1 12.8 0.2 1.1 9.5 0.1 2.2 1 1 1 2 2 2 0 TSC-22/dip/bun family MinC_N PF05209.11 001009449.1_39522001_1 - 0.13 12.1 0.2 0.89 9.4 0.0 2.1 2 0 0 2 2 2 0 Septum formation inhibitor MinC, N-terminal domain PRKG1_interact PF15898.3 001009449.1_39522001_1 - 0.23 12.3 4.8 0.53 11.1 4.8 1.5 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DUF4407 PF14362.4 001009449.1_39522001_1 - 0.7 9.0 4.0 1.1 8.5 4.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4604 PF15377.4 144935.1_32926001_2 - 0.15 12.4 17.2 0.23 11.8 17.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) AP3D1 PF06375.9 144935.1_32926001_2 - 2 8.6 22.1 2.9 8.0 22.1 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 PAP2 PF01569.19 144935.1_32926001_3 - 2.1e-14 53.3 2.4 4e-14 52.4 2.4 1.4 1 0 0 1 1 1 1 PAP2 superfamily PDGF PF00341.15 001009471.1_39522001_1 - 9.5e-23 80.2 11.5 9.5e-23 80.2 11.5 1.6 2 0 0 2 2 2 1 PDGF/VEGF domain PDGF_N PF04692.11 001009471.1_39522001_1 - 2.2e-14 53.9 1.3 3.8e-14 53.2 0.1 2.0 2 0 0 2 2 2 1 Platelet-derived growth factor, N terminal region Isochorismatase PF00857.18 001014242.1_45727001_1 - 4.9e-24 85.3 0.0 7.3e-24 84.7 0.0 1.3 1 0 0 1 1 1 1 Isochorismatase family Glyco_hydro_2_C PF02836.15 001009310.1_22425001_3 - 1.7e-112 375.4 0.2 2.2e-112 375.0 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.16 001009310.1_22425001_3 - 6.1e-20 71.7 0.0 1.3e-19 70.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.19 001009310.1_22425001_3 - 3.4e-08 34.0 0.0 6.7e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_47 PF01532.18 213885.1_49826001_3 - 1.4e-148 495.5 0.0 1.8e-148 495.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 AIM5 PF17050.3 213885.1_49826001_3 - 0.045 13.9 0.1 0.095 12.8 0.1 1.5 1 0 0 1 1 1 0 Altered inheritance of mitochondria 5 Vitellogenin_N PF01347.20 214185.1_49828001_2 - 4.6e-81 272.9 2.2 5.6e-81 272.7 2.2 1.1 1 0 0 1 1 1 1 Lipoprotein amino terminal region VWA_2 PF13519.4 001007663.1_45725001_1 - 3.8e-19 69.2 0.0 6.9e-18 65.1 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain IL8 PF00048.18 001009827.1_22422001_1 - 1.7e-19 69.6 1.1 3e-19 68.8 1.1 1.3 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like 3HCDH_N PF02737.16 213881.1_49824001_3 - 5.4e-49 166.4 0.0 7.8e-49 165.9 0.0 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.20 213881.1_49824001_3 - 1.3e-12 48.0 0.0 2.1e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.13 213881.1_49824001_3 - 0.0031 17.6 0.0 0.0051 16.9 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_N PF03721.12 213881.1_49824001_3 - 0.011 15.2 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_Gly3P_dh_N PF01210.21 213881.1_49824001_3 - 0.033 14.0 0.0 0.058 13.2 0.0 1.4 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.17 213881.1_49824001_3 - 0.055 12.7 0.1 0.087 12.0 0.1 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_8 PF13450.4 213881.1_49824001_3 - 0.13 12.4 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Fz PF01392.20 001032962.1_29624001_1 - 2e-28 99.2 6.5 2e-28 99.2 6.5 3.1 3 0 0 3 3 3 1 Fz domain NTR PF01759.19 001032962.1_29624001_1 - 2.3e-14 53.0 2.0 2.4e-14 52.9 0.3 1.9 1 1 1 2 2 2 1 UNC-6/NTR/C345C module Tetraspannin PF00335.18 001009305.1_22423001_1 - 4e-44 150.8 9.0 4e-44 150.8 9.0 2.8 2 1 0 2 2 2 1 Tetraspanin family Peptidase_C14 PF00656.20 001012433.1_39722001_1 - 4e-55 187.3 0.1 4.8e-55 187.1 0.1 1.1 1 0 0 1 1 1 1 Caspase domain Integrin_beta PF00362.16 213968.1_49828001_1 - 2.6e-114 380.9 0.0 3.4e-114 380.5 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.9 213968.1_49828001_1 - 6.3e-23 80.0 0.4 1.2e-22 79.2 0.4 1.5 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.10 213968.1_49828001_1 - 9e-22 77.2 9.8 9e-22 77.2 9.8 4.0 4 0 0 4 4 4 1 Integrin beta tail domain PSI_integrin PF17205.1 213968.1_49828001_1 - 1.2e-11 44.1 8.2 1.2e-11 44.1 8.2 4.7 3 1 0 3 3 3 1 Integrin plexin domain EGF_2 PF07974.11 213968.1_49828001_1 - 1.3e-07 31.7 58.1 1.7e-06 28.2 13.4 6.6 6 1 0 6 6 6 3 EGF-like domain IGF2_C PF08365.9 001009311.1_39523001_1 - 1.8e-25 88.6 1.9 3.4e-25 87.7 1.9 1.5 1 0 0 1 1 1 1 Insulin-like growth factor II E-peptide Insulin PF00049.16 001009311.1_39523001_1 - 2.1e-13 50.9 5.4 1.7e-06 28.8 2.0 2.5 1 1 1 2 2 2 2 Insulin/IGF/Relaxin family MACPF PF01823.17 214282.1_49826001_1 - 6.8e-43 147.1 0.6 6.8e-43 147.1 0.6 1.7 2 0 0 2 2 2 1 MAC/Perforin domain Sushi PF00084.18 214282.1_49826001_1 - 2.3e-21 76.0 12.1 3e-12 46.8 0.6 3.6 3 0 0 3 3 3 2 Sushi repeat (SCR repeat) Ldl_recept_a PF00057.16 214282.1_49826001_1 - 1.1e-05 25.5 14.0 1.1e-05 25.5 14.0 4.5 5 0 0 5 5 5 1 Low-density lipoprotein receptor domain class A TSP_1 PF00090.17 214282.1_49826001_1 - 0.00016 21.7 22.9 0.0015 18.6 4.1 5.3 6 0 0 6 6 6 2 Thrombospondin type 1 domain Ldl_recept_b PF00058.15 001009381.1_22428001_1 - 1e-48 163.4 6.6 7.5e-11 42.2 0.0 9.4 11 0 0 11 11 11 7 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.4 001009381.1_22428001_1 - 2.6e-28 97.8 127.8 2e-08 34.2 5.8 10.4 9 1 1 10 10 10 6 Coagulation Factor Xa inhibitory site cEGF PF12662.5 001009381.1_22428001_1 - 1.8e-23 82.0 70.6 1.1e-08 34.8 0.9 9.3 10 0 0 10 10 9 7 Complement Clr-like EGF-like EGF_CA PF07645.13 001009381.1_22428001_1 - 2.1e-18 66.1 36.0 1.2e-09 38.1 8.2 10.4 11 0 0 11 11 9 4 Calcium-binding EGF domain EGF PF00008.25 001009381.1_22428001_1 - 6.3e-13 48.6 115.3 4.3e-05 23.6 4.6 10.6 10 0 0 10 10 10 8 EGF-like domain DUF5050 PF16472.3 001009381.1_22428001_1 - 2.2e-12 46.7 0.0 3.5e-06 26.4 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF5050) EGF_3 PF12947.5 001009381.1_22428001_1 - 1.5e-06 28.1 28.0 9.7e-05 22.4 10.2 10.3 10 0 0 10 10 9 5 EGF domain SGL PF08450.10 001009381.1_22428001_1 - 6.9e-05 22.4 0.8 1.2 8.5 0.1 4.9 2 2 1 4 4 4 1 SMP-30/Gluconolaconase/LRE-like region Plasmod_Pvs28 PF06247.9 001009381.1_22428001_1 - 0.001 19.2 6.4 0.001 19.2 6.4 9.9 9 1 1 10 10 10 3 Pvs28 EGF domain Tr-sialidase_C PF11052.6 001009381.1_22428001_1 - 0.039 14.0 5.6 0.14 12.3 5.6 2.0 1 0 0 1 1 1 0 Trans-sialidase of Trypanosoma hydrophobic C-terminal Arylesterase PF01731.18 001009381.1_22428001_1 - 0.16 12.1 0.0 8.9 6.5 0.0 3.1 4 0 0 4 4 4 0 Arylesterase Kunitz_BPTI PF00014.21 001032841.1_29622001_2 - 3.8e-17 62.1 11.0 9.8e-17 60.8 11.0 1.8 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain WAP PF00095.19 001032841.1_29622001_2 - 0.00016 21.9 15.3 0.00016 21.9 15.3 3.3 3 1 0 3 3 3 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Pkinase_Tyr PF07714.15 214172.1_49829001_2 - 1e-93 313.3 0.0 1.5e-93 312.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.22 214172.1_49829001_2 - 2.6e-57 191.6 2.2 2.2e-28 98.5 0.5 2.5 2 0 0 2 2 2 2 Receptor L domain Pkinase PF00069.23 214172.1_49829001_2 - 8.6e-40 136.6 0.0 1.5e-39 135.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.18 214172.1_49829001_2 - 3.5e-38 130.7 37.7 3.5e-38 130.7 37.7 2.0 2 0 0 2 2 2 1 Furin-like cysteine rich region fn3 PF00041.19 214172.1_49829001_2 - 3.3e-18 65.7 11.0 3.1e-05 24.1 0.1 4.7 4 0 0 4 4 4 4 Fibronectin type III domain Kinase-like PF14531.4 214172.1_49829001_2 - 0.0032 16.7 0.0 0.0049 16.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like DUF4476 PF14771.4 214172.1_49829001_2 - 0.17 12.1 0.0 0.36 11.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4476) Carb_anhydrase PF00194.19 001004038.1_49823001_3 - 9.4e-53 179.2 0.0 1.1e-52 179.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase p450 PF00067.20 001048013.1_22424001_1 - 1.9e-101 340.0 0.0 2.3e-101 339.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.20 001009483.1_39524001_2 - 1.8e-136 455.5 0.0 2e-136 455.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Glyco_hydro_18 PF00704.26 001001540.1_49824001_1 - 1.6e-88 297.3 0.0 1.9e-88 297.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 p450 PF00067.20 153318.1_45724001_3 - 8.2e-130 433.5 0.0 1e-129 433.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Fibrinogen_C PF00147.16 213959.1_49825001_2 - 9.5e-69 231.4 5.8 1.5e-68 230.7 5.8 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF4239 PF14023.4 213959.1_49825001_2 - 0.92 9.1 9.7 0.29 10.7 5.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4239) Toxin_30 PF08117.9 213959.1_49825001_3 - 0.37 11.0 6.2 0.92 9.7 6.2 1.6 1 0 0 1 1 1 0 Ptu family Crisp PF08562.8 001032811.1_29623001_1 - 4.1e-05 23.9 1.0 9.1e-05 22.8 1.0 1.6 1 0 0 1 1 1 1 Crisp Crisp PF08562.8 001032811.1_29623001_2 - 1e-17 64.3 16.7 2.1e-17 63.3 16.7 1.6 1 0 0 1 1 1 1 Crisp CAP PF00188.24 001032811.1_29623001_2 - 4.5e-17 62.9 0.5 7.6e-17 62.2 0.5 1.4 1 0 0 1 1 1 1 Cysteine-rich secretory protein family An_peroxidase PF03098.13 001009476.1_39526001_1 - 3.7e-49 167.5 0.0 3.5e-42 144.5 0.0 2.4 1 1 1 2 2 2 2 Animal haem peroxidase EGF PF00008.25 001009476.1_39526001_1 - 6.7e-05 23.0 12.7 0.00023 21.2 12.7 2.0 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.5 001009476.1_39526001_1 - 0.097 13.2 3.9 0.27 11.8 3.9 1.8 1 0 0 1 1 1 0 Human growth factor-like EGF EGF_2 PF07974.11 001009476.1_39526001_1 - 0.63 10.3 14.1 1.4 9.2 14.1 1.6 1 0 0 1 1 1 0 EGF-like domain Xlink PF00193.15 001004028.1_49823001_1 - 8.2e-63 208.7 0.0 8.5e-34 115.7 0.0 2.2 2 0 0 2 2 2 2 Extracellular link domain V-set PF07686.15 001004028.1_49823001_1 - 1.2e-09 38.2 0.0 2.1e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001004028.1_49823001_1 - 5.8e-05 23.5 0.0 0.00014 22.2 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001004028.1_49823001_1 - 0.0016 18.3 0.0 0.0036 17.2 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.23 001004028.1_49823001_1 - 0.0033 17.4 0.0 0.0076 16.3 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001004028.1_49823001_1 - 0.011 15.9 0.0 0.13 12.5 0.0 2.2 1 1 0 1 1 1 0 Immunoglobulin domain 7tm_1 PF00001.19 214217.1_49823001_1 - 6.3e-69 232.1 12.2 9.2e-69 231.5 12.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 214217.1_49823001_1 - 1.6e-16 60.3 16.8 2.3e-16 59.8 16.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 214217.1_49823001_1 - 5.9e-07 29.4 7.8 5.9e-07 29.4 7.8 1.9 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 214217.1_49823001_1 - 0.00051 19.3 15.4 0.00051 19.3 15.4 2.9 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx MscL PF01741.16 214217.1_49823001_1 - 0.16 12.2 1.4 2 8.6 0.4 2.6 2 0 0 2 2 2 0 Large-conductance mechanosensitive channel, MscL 14-3-3 PF00244.18 001009208.1_39523001_2 - 1.4e-101 338.5 1.8 1.7e-101 338.2 1.8 1.1 1 0 0 1 1 1 1 14-3-3 protein DUF837 PF05769.9 001009208.1_39523001_2 - 0.01 15.7 0.8 0.03 14.1 0.4 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF837) PNRC PF15365.4 001009208.1_39523001_2 - 0.9 10.0 0.0 0.9 10.0 0.0 3.4 4 0 0 4 4 4 0 Proline-rich nuclear receptor coactivator EpoR_lig-bind PF09067.8 001001868.1_49824001_1 - 8.2e-24 83.7 0.0 1.6e-23 82.8 0.0 1.4 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding fn3 PF00041.19 001001868.1_49824001_1 - 1.3e-08 34.9 1.5 7.2e-05 22.9 0.1 2.8 2 1 0 2 2 2 2 Fibronectin type III domain IL6Ra-bind PF09240.8 001001868.1_49824001_1 - 2e-08 34.4 0.1 3.6e-08 33.6 0.1 1.4 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding Interfer-bind PF09294.8 001001868.1_49824001_1 - 0.016 15.4 0.0 0.11 12.7 0.0 2.3 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III GHBP PF12772.5 001001868.1_49824001_1 - 0.083 12.3 0.2 0.48 9.8 0.0 2.2 2 0 0 2 2 2 0 Growth hormone receptor binding 7tm_1 PF00001.19 001009078.1_39723001_1 - 3.6e-34 118.1 6.5 4.4e-34 117.8 6.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001009078.1_39723001_1 - 2.4e-07 30.2 7.0 4.3e-07 29.4 7.0 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.7 001009078.1_39723001_1 - 0.0022 17.3 6.2 0.0022 17.3 6.2 1.8 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx NdhL PF10716.7 001009078.1_39723001_1 - 0.0057 16.5 1.9 0.016 15.0 0.0 2.6 3 0 0 3 3 3 1 NADH dehydrogenase transmembrane subunit Shisa PF13908.4 001009078.1_39723001_1 - 0.28 11.3 4.7 8.5 6.4 0.2 3.2 2 1 1 3 3 3 0 Wnt and FGF inhibitory regulator DUF3341 PF11821.6 001009078.1_39723001_1 - 0.89 9.0 4.8 11 5.5 4.8 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3341) ZF-HD_dimer PF04770.10 001032942.1_29623001_1 - 0.056 13.7 2.1 0.12 12.6 2.1 1.5 1 0 0 1 1 1 0 ZF-HD protein dimerisation region 7tm_1 PF00001.19 001032942.1_29623001_2 - 3.2e-41 141.2 15.8 4.2e-41 140.8 15.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Phospholip_A2_1 PF00068.17 001004037.1_49822001_2 - 6.9e-38 129.4 14.6 8.2e-38 129.1 14.6 1.1 1 0 0 1 1 1 1 Phospholipase A2 Phospholip_A2_2 PF05826.10 001004037.1_49822001_2 - 1.1 9.4 16.9 0.5 10.5 10.1 2.2 1 1 1 2 2 2 0 Phospholipase A2 Crystallin PF00525.16 001012458.1_39522001_2 - 1.2e-26 92.5 2.4 2.5e-26 91.5 2.4 1.5 1 0 0 1 1 1 1 Alpha crystallin A chain, N terminal HSP20 PF00011.19 001012458.1_39522001_2 - 1e-22 80.0 0.0 1.3e-22 79.7 0.0 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family RnaseA PF00074.18 001009133.1_39722001_1 - 1.8e-33 115.5 13.0 2.2e-33 115.2 13.0 1.1 1 0 0 1 1 1 1 Pancreatic ribonuclease p450 PF00067.20 214427.1_49824001_2 - 1e-121 406.8 0.2 1.2e-121 406.6 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 BK_channel_a PF03493.16 198762.1_45728001_1 - 2.5e-29 101.3 1.3 6.3e-29 100.0 0.2 2.4 2 0 0 2 2 2 1 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.14 198762.1_45728001_1 - 1e-13 50.9 5.4 2.9e-13 49.5 3.9 2.5 3 0 0 3 3 3 1 Ion channel Anophelin PF10731.7 198762.1_45728001_1 - 0.047 13.4 0.7 0.13 12.0 0.7 1.7 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito TrkA_C PF02080.19 198762.1_45728001_1 - 0.081 12.6 0.0 3 7.6 0.1 2.4 2 0 0 2 2 2 0 TrkA-C domain Ion_trans PF00520.29 198762.1_45728001_1 - 0.12 11.4 14.4 0.25 10.4 14.4 1.5 1 0 0 1 1 1 0 Ion transport protein TrkA_N PF02254.16 198762.1_45728001_1 - 0.16 12.1 0.0 0.69 10.1 0.0 2.0 2 0 0 2 2 2 0 TrkA-N domain FAD_binding_3 PF01494.17 214076.1_49824001_2 - 2.6e-20 72.9 0.0 3.6e-20 72.4 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.4 214076.1_49824001_2 - 4.5e-06 26.7 0.0 1.3e-05 25.2 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 214076.1_49824001_2 - 3.3e-05 23.5 0.0 0.0022 17.5 0.0 2.1 1 1 1 2 2 2 1 FAD dependent oxidoreductase SE PF08491.8 214076.1_49824001_2 - 0.00034 19.6 0.0 0.013 14.4 0.0 2.2 2 0 0 2 2 2 1 Squalene epoxidase 3HCDH_N PF02737.16 214076.1_49824001_2 - 0.022 14.5 0.0 0.032 14.0 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.25 214076.1_49824001_2 - 0.025 15.0 0.0 0.05 14.0 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.12 214076.1_49824001_2 - 0.073 12.2 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FHA PF00498.24 001042382.1_39729001_1 - 1.4e-10 41.2 0.0 2.8e-10 40.2 0.0 1.5 1 0 0 1 1 1 1 FHA domain RTT107_BRCT_5 PF16770.3 001042382.1_39729001_1 - 6.8e-07 29.0 0.0 1.5e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT PF00533.24 001042382.1_39729001_1 - 0.0054 17.0 0.0 0.035 14.4 0.0 2.2 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Yop-YscD_cpl PF16697.3 001042382.1_39729001_1 - 0.011 15.9 0.0 0.026 14.7 0.0 1.6 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain RAWUL PF16207.3 001024962.1_22422001_1 - 3.6e-22 78.6 0.6 8.8e-22 77.4 0.6 1.7 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_2 PF13923.4 001024962.1_22422001_1 - 1.2e-10 40.9 7.4 2.1e-10 40.1 7.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001024962.1_22422001_1 - 3.2e-09 36.4 8.1 6.6e-09 35.4 8.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001024962.1_22422001_1 - 5.5e-07 29.6 7.0 1.1e-06 28.7 7.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.4 001024962.1_22422001_1 - 1e-06 28.4 7.1 1.6e-06 27.7 7.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001024962.1_22422001_1 - 4.2e-05 23.3 7.8 0.00011 21.9 7.8 1.7 1 1 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.5 001024962.1_22422001_1 - 0.00011 22.2 4.8 0.00028 21.0 4.8 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.4 001024962.1_22422001_1 - 0.00085 19.2 2.6 0.00085 19.2 2.6 2.1 2 1 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.4 001024962.1_22422001_1 - 0.00086 19.0 6.1 0.0019 17.9 6.1 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.4 001024962.1_22422001_1 - 0.02 14.9 9.9 0.055 13.5 9.9 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.3 001024962.1_22422001_1 - 0.082 12.9 4.7 0.18 11.9 4.7 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-Nse PF11789.6 001024962.1_22422001_1 - 0.1 12.3 5.5 0.17 11.6 4.8 1.8 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-P11 PF03854.12 001024962.1_22422001_1 - 0.48 10.0 6.4 1.1 8.9 6.4 1.6 1 1 0 1 1 1 0 P-11 zinc finger zf-C3HC4_5 PF17121.3 001024962.1_22422001_1 - 7.7 6.4 8.4 39 4.1 8.4 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) PA28_beta PF02252.16 214304.1_49822001_1 - 9.4e-56 187.4 0.1 1.6e-55 186.6 0.1 1.4 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.16 214304.1_49822001_1 - 9.4e-24 83.2 1.0 9.4e-24 83.2 1.0 1.8 2 0 0 2 2 2 1 Proteasome activator pa28 alpha subunit ARF7EP_C PF14949.4 001014045.1_45723001_1 - 9.1e-37 125.7 4.4 2.1e-36 124.6 4.4 1.7 1 0 0 1 1 1 1 ARF7 effector protein C-terminus Peptidase_C1 PF00112.21 001032812.2_29623001_2 - 4.3e-83 278.6 4.9 5.5e-83 278.2 4.9 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 001032812.2_29623001_2 - 4.7e-11 42.8 0.3 8.9e-11 41.9 0.3 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 001032812.2_29623001_2 - 2.4e-08 33.0 1.2 5.8e-05 21.9 0.6 2.2 2 0 0 2 2 2 2 Peptidase C1-like family DPPIV_N PF00930.19 214257.1_49825001_1 - 1.7e-108 362.4 8.7 2.2e-108 362.0 8.7 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.19 214257.1_49825001_1 - 1.6e-58 197.5 2.7 1.6e-58 197.5 2.7 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family DLH PF01738.16 214257.1_49825001_1 - 1.1e-05 25.0 0.0 2.8e-05 23.6 0.0 1.5 1 1 0 1 1 1 1 Dienelactone hydrolase family LIP PF03583.12 214257.1_49825001_1 - 5.8e-05 22.4 0.4 0.00043 19.6 0.1 2.3 3 0 0 3 3 3 1 Secretory lipase Abhydrolase_6 PF12697.5 214257.1_49825001_1 - 0.0019 18.7 0.0 0.0079 16.7 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.14 214257.1_49825001_1 - 0.012 15.3 1.3 0.32 10.6 0.4 2.5 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase PD40 PF07676.10 214257.1_49825001_1 - 0.042 13.7 1.8 54 3.7 0.1 4.7 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Peptidase_S15 PF02129.16 214257.1_49825001_1 - 0.39 10.1 10.6 0.54 9.7 0.7 3.1 2 1 1 3 3 3 0 X-Pro dipeptidyl-peptidase (S15 family) FGF PF00167.16 213801.1_49822001_2 - 4.4e-47 159.2 0.2 5.5e-47 158.8 0.2 1.1 1 0 0 1 1 1 1 Fibroblast growth factor DUF3361 PF11841.6 001030028.1_45725001_1 - 2.9e-52 176.6 0.5 6.4e-52 175.5 0.3 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3361) ELMO_CED12 PF04727.11 001030028.1_45725001_1 - 1.2e-43 149.1 0.0 2.3e-43 148.2 0.0 1.5 1 0 0 1 1 1 1 ELMO/CED-12 family PH_12 PF16457.3 001030028.1_45725001_1 - 1.4e-33 116.2 0.7 2e-33 115.6 0.0 1.7 2 0 0 2 2 2 1 Pleckstrin homology domain Neur_chan_memb PF02932.14 001033935.1_39724001_1 - 6.3e-94 314.4 0.0 8.2e-94 314.0 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 001033935.1_39724001_1 - 2e-80 269.2 2.0 2.5e-80 268.8 2.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Atrophin-1 PF03154.13 001033935.1_39724001_1 - 0.015 13.5 0.3 0.022 12.9 0.3 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF2417 PF10329.7 001033935.1_39724001_1 - 0.36 10.1 10.0 1 8.6 9.2 1.9 2 0 0 2 2 2 0 Region of unknown function (DUF2417) 7tm_1 PF00001.19 001012442.1_39724001_1 - 2.1e-79 266.4 2.3 2.8e-79 266.0 2.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001012442.1_39724001_1 - 6.1e-08 32.2 11.3 3.7e-07 29.7 2.3 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001012442.1_39724001_1 - 2.7e-06 26.8 5.0 2.7e-06 26.8 5.0 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001012442.1_39724001_1 - 2.7e-05 23.9 1.5 2.7e-05 23.9 1.5 2.4 3 0 0 3 3 3 2 Olfactory receptor 7TM_GPCR_Srbc PF10316.7 001012442.1_39724001_1 - 0.0022 17.4 7.2 0.0022 17.4 7.2 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc DUF2693 PF10902.6 001012442.1_39724001_1 - 0.15 11.9 0.0 0.41 10.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2693) DUF2417 PF10329.7 001012442.1_39724001_1 - 2.2 7.5 9.5 7.6 5.7 7.0 2.5 2 1 0 2 2 2 0 Region of unknown function (DUF2417) ICAM_N PF03921.12 001009166.1_39722001_2 - 2.3e-41 139.2 1.1 4.5e-41 138.3 1.1 1.5 1 0 0 1 1 1 1 Intercellular adhesion molecule (ICAM), N-terminal domain Ig_2 PF13895.4 001009166.1_39722001_2 - 0.032 14.5 0.4 0.17 12.1 0.0 2.2 2 1 0 2 2 2 0 Immunoglobulin domain Ig_3 PF13927.4 001009166.1_39722001_2 - 0.066 13.7 0.2 0.41 11.1 0.0 2.3 3 0 0 3 3 3 0 Immunoglobulin domain V-set PF07686.15 001009166.1_39722001_2 - 0.092 12.8 0.5 18 5.4 0.0 2.6 1 1 2 3 3 3 0 Immunoglobulin V-set domain ig PF00047.23 001009166.1_39722001_2 - 0.14 12.2 0.9 0.34 11.0 0.0 2.1 3 0 0 3 3 3 0 Immunoglobulin domain IL8 PF00048.18 001009847.1_22421001_2 - 1.1e-07 31.8 1.4 1.8e-07 31.1 1.4 1.3 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Lipocalin PF00061.21 001031780.1_49822001_2 - 3.1e-14 53.2 2.4 3.7e-14 53.0 2.4 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 001031780.1_49822001_2 - 2.4e-08 33.8 2.5 3e-08 33.5 2.5 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_4 PF13648.4 001031780.1_49822001_2 - 0.0025 18.6 3.0 0.0053 17.5 3.0 1.6 1 1 0 1 1 1 1 Lipocalin-like domain DUF3994 PF13159.4 001031780.1_49822001_2 - 0.13 12.5 1.0 0.23 11.7 0.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3994) Filament PF00038.19 001004022.2_45724001_3 - 2.1e-117 392.0 32.2 2.4e-117 391.8 32.2 1.0 1 0 0 1 1 1 1 Intermediate filament protein Atg14 PF10186.7 001004022.2_45724001_3 - 0.00023 20.2 1.1 0.00023 20.2 1.1 2.4 2 1 1 3 3 3 1 Vacuolar sorting 38 and autophagy-related subunit 14 TPR_MLP1_2 PF07926.10 001004022.2_45724001_3 - 0.0031 17.4 2.2 0.0031 17.4 2.2 3.9 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein SPATA1_C PF15743.3 001004022.2_45724001_3 - 0.028 14.4 0.2 0.028 14.4 0.2 3.8 1 1 2 3 3 2 0 Spermatogenesis-associated C-terminus Reo_sigmaC PF04582.10 001004022.2_45724001_3 - 0.043 13.1 5.1 0.067 12.4 1.3 2.3 2 1 1 3 3 3 0 Reovirus sigma C capsid protein Bacillus_HBL PF05791.9 001004022.2_45724001_3 - 0.05 13.2 8.6 0.048 13.3 1.9 2.5 1 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Jnk-SapK_ap_N PF09744.7 001004022.2_45724001_3 - 0.12 12.5 26.2 0.84 9.7 5.8 3.5 1 1 3 4 4 4 0 JNK_SAPK-associated protein-1 Baculo_PEP_C PF04513.10 001004022.2_45724001_3 - 0.12 12.3 15.3 4 7.3 1.0 3.6 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4686 PF15742.3 001004022.2_45724001_3 - 0.15 11.1 26.5 0.23 10.4 4.5 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4686) DUF4407 PF14362.4 001004022.2_45724001_3 - 0.57 9.4 16.1 1.8 7.7 8.9 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF1664 PF07889.10 001004022.2_45724001_3 - 0.57 10.0 16.4 0.66 9.9 2.2 4.1 2 1 3 5 5 5 0 Protein of unknown function (DUF1664) SlyX PF04102.10 001004022.2_45724001_3 - 0.58 10.7 25.7 1.7 9.2 0.6 5.2 4 1 1 5 5 5 0 SlyX FlxA PF14282.4 001004022.2_45724001_3 - 0.85 9.5 14.5 6.2 6.7 0.5 2.6 2 0 0 2 2 2 0 FlxA-like protein POX PF07526.9 001004022.2_45724001_3 - 1.8 9.0 5.5 5.1 7.6 0.4 3.0 2 2 1 3 3 3 0 Associated with HOX Fib_alpha PF08702.8 001004022.2_45724001_3 - 1.9 8.6 19.0 6.5 6.8 6.4 3.5 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DUF4709 PF15821.3 001004022.2_45724001_3 - 1.9 8.6 13.0 6.7 6.9 3.5 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4709) Keratin_2_head PF16208.3 001004022.2_45724001_3 - 1.9 8.5 48.7 0.067 13.2 42.3 1.7 2 0 0 2 2 2 0 Keratin type II head AAA_13 PF13166.4 001004022.2_45724001_3 - 3 6.3 15.6 0.67 8.4 10.7 1.8 1 1 1 2 2 2 0 AAA domain DUF641 PF04859.10 001004022.2_45724001_3 - 4.5 7.5 17.2 8.1 6.7 2.0 3.5 2 2 1 3 3 3 0 Plant protein of unknown function (DUF641) CENP-F_leu_zip PF10473.7 001004022.2_45724001_3 - 4.6 7.1 29.4 1.1 9.1 4.2 4.2 3 1 1 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 RasGAP_C PF03836.13 001004022.2_45724001_3 - 5.1 7.1 16.6 1.3 9.0 0.1 3.7 3 1 1 4 4 4 0 RasGAP C-terminus DUF4446 PF14584.4 001004022.2_45724001_3 - 7.4 6.4 13.0 4 7.3 0.0 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF4446) Serpin PF00079.18 001009393.1_39524001_3 - 2.9e-117 392.0 1.5 3.3e-117 391.8 1.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Tr-sialidase_C PF11052.6 001009393.1_39524001_3 - 0.1 12.7 0.4 0.3 11.2 0.4 1.7 1 0 0 1 1 1 0 Trans-sialidase of Trypanosoma hydrophobic C-terminal NMDAR2_C PF10565.7 001034189.1_39729001_1 - 6.1e-263 874.5 32.4 7.3e-263 874.3 32.4 1.1 1 0 0 1 1 1 1 N-methyl D-aspartate receptor 2B3 C-terminus Lig_chan PF00060.24 001034189.1_39729001_1 - 2.8e-35 121.2 0.2 5.8e-35 120.2 0.2 1.6 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.7 001034189.1_39729001_1 - 4e-30 104.2 0.1 1.9e-29 102.1 0.1 2.1 1 1 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.18 001034189.1_39729001_1 - 1.1e-20 73.9 0.0 1.9e-20 73.1 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 ANF_receptor PF01094.26 001034189.1_39729001_1 - 1.8e-12 46.9 0.1 3.5e-12 46.0 0.1 1.4 1 0 0 1 1 1 1 Receptor family ligand binding region Kringle PF00051.16 001009830.1_22427001_2 - 1.5e-110 361.5 44.7 2.6e-28 98.0 7.7 4.5 4 0 0 4 4 4 4 Kringle domain Trypsin PF00089.24 001009830.1_22427001_2 - 2.6e-50 171.1 0.1 4.1e-50 170.5 0.1 1.3 1 0 0 1 1 1 1 Trypsin PAN_1 PF00024.24 001009830.1_22427001_2 - 2.3e-09 37.0 0.5 5.9e-09 35.6 0.5 1.7 1 0 0 1 1 1 1 PAN domain DUF1986 PF09342.9 001009830.1_22427001_2 - 0.019 15.2 0.0 0.037 14.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) zf-H2C2_2 PF13465.4 144749.1_45726001_3 - 4.9e-63 206.8 59.4 1.6e-07 31.3 4.7 12.5 12 0 0 12 12 12 10 Zinc-finger double domain zf-C2H2 PF00096.24 144749.1_45726001_3 - 1.8e-46 154.0 77.4 2.9e-06 27.3 1.1 11.2 11 0 0 11 11 11 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 144749.1_45726001_3 - 9.9e-28 94.3 70.1 0.00046 20.7 0.5 11.2 11 0 0 11 11 11 9 C2H2-type zinc finger KRAB PF01352.25 144749.1_45726001_3 - 2.8e-24 84.4 0.1 5e-24 83.6 0.1 1.5 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 144749.1_45726001_3 - 9.3e-08 31.9 43.4 0.0034 17.4 1.0 7.4 5 1 4 9 9 9 5 Zinc ribbon domain zf-C2H2_6 PF13912.4 144749.1_45726001_3 - 9.3e-08 31.7 67.9 0.018 14.9 0.2 10.9 11 0 0 11 11 10 8 C2H2-type zinc finger DUF3268 PF11672.6 144749.1_45726001_3 - 4.8e-05 23.5 32.0 0.11 12.7 1.2 5.6 4 2 1 6 6 6 3 zinc-finger-containing domain zf-Di19 PF05605.10 144749.1_45726001_3 - 0.002 18.2 1.0 0.002 18.2 1.0 5.4 2 1 3 6 6 6 2 Drought induced 19 protein (Di19), zinc-binding C1_4 PF07975.10 144749.1_45726001_3 - 0.014 15.5 39.6 1.2 9.3 6.7 6.4 4 2 2 7 7 7 0 TFIIH C1-like domain zinc_ribbon_15 PF17032.3 144749.1_45726001_3 - 0.026 15.1 37.2 0.76 10.4 1.9 5.6 2 1 4 7 7 7 0 zinc-ribbon family FYDLN_acid PF09538.8 144749.1_45726001_3 - 0.06 13.9 20.5 8.7 7.0 0.0 7.5 2 2 5 7 7 7 0 Protein of unknown function (FYDLN_acid) Zn_Tnp_IS1595 PF12760.5 144749.1_45726001_3 - 0.53 10.2 48.4 0.054 13.4 3.0 6.9 5 2 2 7 7 7 0 Transposase zinc-ribbon domain zf-LYAR PF08790.9 144749.1_45726001_3 - 2.1 8.2 39.4 0.12 12.1 0.4 9.2 9 0 0 9 9 9 0 LYAR-type C2HC zinc finger zinc_ribbon_9 PF14369.4 144749.1_45726001_3 - 2.5 8.3 32.4 15 5.8 0.8 9.6 10 0 0 10 10 10 0 zinc-ribbon CpXC PF14353.4 144749.1_45726001_3 - 3.6 7.5 37.4 9.1 6.2 0.1 8.8 3 1 2 6 6 6 0 CpXC protein GDI PF00996.16 001009061.1_39723001_1 - 3e-242 803.6 0.1 3.5e-242 803.3 0.1 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor Amino_oxidase PF01593.22 001009061.1_39723001_1 - 0.014 14.6 0.0 0.019 14.2 0.0 1.1 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase Parathyroid PF01279.15 001009210.1_22422001_1 - 3.1e-06 27.6 0.1 5.2e-06 26.9 0.1 1.4 1 0 0 1 1 1 1 Parathyroid hormone family ABC_ATPase PF09818.7 001009210.1_22422001_1 - 0.047 12.4 0.0 0.062 12.0 0.0 1.1 1 0 0 1 1 1 0 Predicted ATPase of the ABC class HMG_box PF00505.17 001008988.1_39722001_1 - 6.6e-26 90.4 6.8 1.1e-25 89.7 6.8 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 001008988.1_39722001_1 - 2e-08 34.5 6.2 3.9e-08 33.6 6.2 1.5 1 0 0 1 1 1 1 HMG-box domain RGS12_us1 PF16613.3 001008988.1_39722001_1 - 0.094 12.9 1.0 0.16 12.2 1.0 1.3 1 0 0 1 1 1 0 Unstructured region of RGS12 p450 PF00067.20 138514.1_45724001_3 - 7.9e-149 496.2 0.0 9e-149 496.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 zf-CCCH PF00642.22 001045499.1_39722001_1 - 6.4e-06 25.8 4.4 1.1e-05 25.0 4.4 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.4 001045499.1_39722001_1 - 0.48 10.8 6.1 1 9.8 6.1 1.6 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger C8 PF08742.9 001008373.1_45725001_2 - 0.0086 16.3 0.4 0.023 15.0 0.4 1.6 1 0 0 1 1 1 1 C8 domain zf-CCHC_3 PF13917.4 001008373.1_45725001_3 - 9.5e-07 28.6 0.0 2.7e-06 27.1 0.0 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.21 001008373.1_45725001_3 - 0.11 12.5 2.7 0.35 10.9 2.7 2.0 1 0 0 1 1 1 0 Zinc knuckle RRM_1 PF00076.20 001034118.1_39724001_1 - 1.3e-21 76.0 0.0 2.1e-21 75.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 001034118.1_39724001_1 - 0.0078 16.0 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif MIP PF00230.18 001009273.2_39522001_1 - 5.4e-73 245.3 17.3 6.5e-73 245.1 17.3 1.0 1 0 0 1 1 1 1 Major intrinsic protein SNF2_N PF00176.21 001009018.1_39729001_1 - 3.9e-64 216.4 0.2 9.7e-64 215.1 0.2 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.29 001009018.1_39729001_1 - 2.3e-15 56.8 0.0 1e-14 54.7 0.0 2.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Y_phosphatase PF00102.25 033099.1_45729001_1 - 2e-96 322.0 0.0 1.4e-80 270.2 0.0 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.19 033099.1_45729001_1 - 3.6e-42 142.5 0.0 1.6e-07 31.5 0.0 9.9 10 0 0 10 10 10 6 Fibronectin type III domain Y_phosphatase3 PF13350.4 033099.1_45729001_1 - 5.6e-06 26.4 0.0 9.3e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.18 033099.1_45729001_1 - 0.00015 21.4 0.0 0.00028 20.6 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 033099.1_45729001_1 - 0.0025 17.8 0.0 0.0049 16.9 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase2 PF03162.11 033099.1_45729001_1 - 0.02 14.4 0.0 0.039 13.4 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Myotub-related PF06602.12 033099.1_45729001_1 - 0.058 12.2 0.0 0.097 11.5 0.0 1.2 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain VWC PF00093.16 033099.1_45729001_1 - 0.18 12.0 1.4 0.42 10.8 1.4 1.5 1 0 0 1 1 1 0 von Willebrand factor type C domain Caveolin PF01146.15 001135818.1_39726001_2 - 7.3e-59 197.4 3.0 9.5e-59 197.0 1.6 1.8 2 0 0 2 2 2 1 Caveolin IL8 PF00048.18 001009401.2_39523001_2 - 3e-17 62.4 2.1 5.3e-17 61.6 1.2 1.9 2 0 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like GDI PF00996.16 001001643.1_49825001_1 - 2.7e-233 774.0 0.1 3.3e-233 773.8 0.1 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor p450 PF00067.20 001024859.1_22426001_1 - 2.9e-105 352.6 0.0 3.7e-105 352.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.20 214426.1_49824001_1 - 2.1e-49 168.4 0.1 2.8e-49 168.0 0.1 1.2 1 0 0 1 1 1 1 Cytochrome P450 An_peroxidase PF03098.13 001009432.1_39527001_1 - 2.6e-52 178.0 0.1 4e-45 154.3 0.1 2.1 1 1 1 2 2 2 2 Animal haem peroxidase EGF PF00008.25 001009432.1_39527001_1 - 0.0001 22.4 11.6 0.00025 21.1 11.6 1.7 1 0 0 1 1 1 1 EGF-like domain 7tm_1 PF00001.19 001032931.1_29624001_1 - 7.6e-80 267.9 1.8 1e-79 267.4 1.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001032931.1_29624001_1 - 6.2e-08 32.2 11.9 2.8e-07 30.0 2.5 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001032931.1_29624001_1 - 1.2e-06 27.9 3.8 1.2e-06 27.9 3.8 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001032931.1_29624001_1 - 2.6e-05 24.0 2.3 2.6e-05 24.0 2.3 2.4 3 0 0 3 3 3 2 Olfactory receptor 7TM_GPCR_Srbc PF10316.7 001032931.1_29624001_1 - 0.0022 17.4 7.0 0.0022 17.4 7.0 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc DUF2417 PF10329.7 001032931.1_29624001_1 - 1.5 8.1 9.6 8 5.7 7.1 2.5 2 1 0 2 2 2 0 Region of unknown function (DUF2417) HMG_box PF00505.17 001009240.1_22422001_1 - 3.2e-25 88.2 2.6 5.5e-25 87.4 2.6 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 001009240.1_22422001_1 - 6.5e-08 32.9 2.5 1.1e-07 32.2 2.5 1.4 1 0 0 1 1 1 1 HMG-box domain Amidase_2 PF01510.23 213738.1_49824001_2 - 1.4e-13 51.2 0.0 2.4e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase Ammonium_transp PF00909.19 001009091.2_39724001_3 - 4.4e-73 246.1 22.3 5.5e-73 245.8 22.3 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family 7tm_1 PF00001.19 001009336.1_22423001_1 - 7.7e-67 225.2 4.0 1.7e-66 224.1 4.0 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001009336.1_22423001_1 - 1.8e-10 40.5 0.0 1.6e-09 37.4 0.0 2.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001009336.1_22423001_1 - 1e-06 28.6 1.2 1.8e-06 27.8 1.2 1.3 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001009336.1_22423001_1 - 0.00094 18.4 0.9 0.0014 17.9 0.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.7 001009336.1_22423001_1 - 0.032 13.5 1.3 0.06 12.5 1.1 1.5 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv CDKN3 PF05706.10 214320.1_49822001_1 - 4.1e-112 371.3 0.6 4.9e-112 371.0 0.6 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase PF00102.25 214320.1_49822001_1 - 3e-06 26.9 0.0 3.7e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.18 214320.1_49822001_1 - 4.5e-06 26.4 0.0 8e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Aldo_ket_red PF00248.19 213890.2_49823001_1 - 6.4e-53 179.7 0.0 8.5e-53 179.3 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family E1_DerP2_DerF2 PF02221.13 214206.1_49823001_1 - 1.7e-30 106.0 2.5 2.4e-30 105.6 2.5 1.2 1 0 0 1 1 1 1 ML domain V-set PF07686.15 001009016.1_39722001_1 - 6.2e-07 29.4 0.0 1.4e-06 28.3 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001009016.1_39722001_1 - 8.7e-06 26.1 0.0 3.5e-05 24.2 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001009016.1_39722001_1 - 0.0013 18.7 0.0 0.0073 16.3 0.0 2.0 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001009016.1_39722001_1 - 0.0014 18.5 0.0 0.0029 17.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 001009016.1_39722001_1 - 0.017 15.3 0.0 0.082 13.1 0.0 2.1 2 1 0 2 2 2 0 Immunoglobulin domain IL8 PF00048.18 001009281.1_22422001_2 - 4.9e-16 58.5 1.3 4.9e-16 58.5 1.3 1.6 2 0 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like DUF4749 PF15936.3 001001637.1_49823001_2 - 1.4e-26 93.4 0.1 2.1e-26 92.8 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) PDZ PF00595.22 001001637.1_49823001_2 - 4.8e-16 58.7 0.0 8.5e-16 58.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) LIM PF00412.20 001001637.1_49823001_2 - 2.6e-13 49.8 3.0 4e-13 49.2 3.0 1.3 1 0 0 1 1 1 1 LIM domain PDZ_2 PF13180.4 001001637.1_49823001_2 - 0.00038 20.6 0.0 0.00082 19.5 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Lar_restr_allev PF14354.4 001001637.1_49823001_2 - 0.21 11.9 2.4 0.42 10.9 2.4 1.5 1 0 0 1 1 1 0 Restriction alleviation protein Lar Urotensin_II PF02083.13 001032895.1_29621001_1 - 3.2e-07 29.5 2.4 5.4e-07 28.8 2.4 1.4 1 0 0 1 1 1 1 Urotensin II WW PF00397.24 001013957.1_45723001_2 - 1.4e-06 28.0 0.5 2.5e-06 27.2 0.5 1.5 1 0 0 1 1 1 1 WW domain MIP-T3 PF10243.7 001013957.1_45723001_2 - 1.1 7.8 25.6 1.6 7.3 25.6 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF1777 PF08648.10 001013957.1_45723001_2 - 5.3 7.1 36.7 9.6 6.3 36.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) Filament PF00038.19 001009445.1_39523001_3 - 9.5e-108 360.3 35.6 1.1e-107 360.1 35.6 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 001009445.1_39523001_3 - 0.0047 16.8 2.5 0.0047 16.8 2.5 3.9 3 2 0 3 3 3 1 TPR/MLP1/MLP2-like protein Lipoprotein_7 PF01540.14 001009445.1_39523001_3 - 0.0076 15.4 1.0 0.012 14.8 1.0 1.2 1 0 0 1 1 1 1 Adhesin lipoprotein Lzipper-MIP1 PF14389.4 001009445.1_39523001_3 - 0.0087 16.2 3.7 0.0087 16.2 3.7 4.3 3 2 1 4 4 4 1 Leucine-zipper of ternary complex factor MIP1 Uso1_p115_C PF04871.11 001009445.1_39523001_3 - 0.11 12.7 20.2 0.16 12.2 3.6 3.1 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF1664 PF07889.10 001009445.1_39523001_3 - 0.17 11.7 16.3 0.8 9.6 0.7 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.10 001009445.1_39523001_3 - 0.41 10.5 18.6 6.2 6.7 1.5 3.1 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus CREPT PF16566.3 001009445.1_39523001_3 - 0.76 9.8 19.5 2.5 8.1 1.0 3.4 3 0 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour ERM PF00769.17 001009445.1_39523001_3 - 0.83 9.3 23.0 0.054 13.2 12.9 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family ADIP PF11559.6 001009445.1_39523001_3 - 1.9 8.4 31.0 1.2 9.1 13.3 3.2 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding DUF342 PF03961.11 001009445.1_39523001_3 - 8.1 4.8 17.8 0.41 9.1 8.9 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF342) S_100 PF01023.17 214140.2_49821001_2 - 2.1e-13 49.6 0.5 6.7e-13 48.0 0.2 1.9 2 0 0 2 2 2 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.30 214140.2_49821001_2 - 4.2e-10 38.3 1.8 1.2e-08 33.7 0.6 2.9 3 0 0 3 3 3 1 EF hand EF-hand_5 PF13202.4 214140.2_49821001_2 - 1e-09 37.4 3.9 2.4e-08 33.0 1.2 2.5 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.4 214140.2_49821001_2 - 1.8e-08 34.6 0.2 3.5e-08 33.7 0.2 1.6 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 214140.2_49821001_2 - 2.2e-08 33.2 0.5 9.6e-06 25.0 0.2 2.5 2 1 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.4 214140.2_49821001_2 - 3.2e-06 26.7 0.1 6.5e-06 25.7 0.1 1.5 1 1 0 1 1 1 1 EF-hand domain pair Caleosin PF05042.11 214140.2_49821001_2 - 0.1 12.4 0.1 2.7 7.8 0.1 2.0 2 0 0 2 2 2 0 Caleosin related protein WD40 PF00400.30 214025.2_49824001_3 - 6.6e-07 29.8 2.3 11 6.9 0.0 6.4 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 214025.2_49824001_3 - 0.00015 21.9 0.1 1.9 8.7 0.0 4.3 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Lactamase_B_3 PF13483.4 001009041.1_39725001_1 - 3.3e-09 36.7 0.0 6.3e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Rieske PF00355.24 001009041.1_39725001_1 - 6.7e-06 25.8 0.8 1.8e-05 24.4 0.0 1.9 2 0 0 2 2 2 1 Rieske [2Fe-2S] domain Lactamase_B_2 PF12706.5 001009041.1_39725001_1 - 0.00038 19.9 0.0 0.00058 19.3 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain AF-4 PF05110.11 001009042.1_39728001_1 - 0 1248.4 53.8 6.6e-267 889.0 31.2 2.0 1 1 1 2 2 2 2 AF-4 proto-oncoprotein MFS_1 PF07690.14 001009742.1_39526001_3 - 4.6e-58 196.7 35.8 1.2e-57 195.3 28.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Ets PF00178.20 001001865.1_49823001_2 - 1.2e-22 80.1 2.4 1.9e-22 79.4 2.4 1.4 1 0 0 1 1 1 1 Ets-domain zf-C3HC4 PF00097.23 001024271.1_45726001_3 - 8.2e-10 38.3 7.5 1.9e-09 37.1 7.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001024271.1_45726001_3 - 1e-09 38.0 5.3 1e-09 38.0 5.3 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001024271.1_45726001_3 - 2.7e-09 37.0 9.9 6.8e-09 35.7 9.9 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.4 001024271.1_45726001_3 - 4e-08 32.8 8.9 4e-08 32.8 8.9 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 001024271.1_45726001_3 - 2.8e-06 27.0 6.7 2.8e-06 27.0 6.7 2.0 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.4 001024271.1_45726001_3 - 6.9e-06 25.8 6.4 4.1e-05 23.4 6.8 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.4 001024271.1_45726001_3 - 9.4e-06 25.4 6.3 9.4e-06 25.4 6.3 1.7 2 0 0 2 2 1 1 zinc-RING finger domain zf-rbx1 PF12678.5 001024271.1_45726001_3 - 0.00019 21.5 8.0 0.0004 20.5 8.0 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.5 001024271.1_45726001_3 - 0.00061 19.7 2.9 0.0015 18.4 2.9 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.4 001024271.1_45726001_3 - 0.0026 17.8 7.5 0.0057 16.7 7.5 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Baculo_IE-1 PF05290.9 001024271.1_45726001_3 - 0.0047 16.7 2.0 0.008 16.0 2.0 1.3 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-UDP PF14569.4 001024271.1_45726001_3 - 0.16 12.0 0.9 0.36 10.9 0.9 1.5 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-RING_11 PF17123.3 001024271.1_45726001_3 - 0.34 10.5 4.0 0.8 9.3 4.0 1.7 1 0 0 1 1 1 0 RING-like zinc finger Zn_ribbon_17 PF17120.3 001024271.1_45726001_3 - 6.9 6.3 8.8 2.8 7.5 5.8 1.9 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type F5_F8_type_C PF00754.23 214120.1_49829001_1 - 8.4e-56 187.4 11.3 2.7e-29 101.7 1.7 3.0 2 0 0 2 2 2 2 F5/8 type C domain LSPR PF06049.10 214120.1_49829001_1 - 3e-50 159.4 235.2 0.24 11.3 0.5 39.2 39 0 0 39 39 39 33 Coagulation Factor V LSPD Repeat Cu-oxidase_3 PF07732.13 214120.1_49829001_1 - 6.3e-24 84.2 1.8 2.1e-06 27.6 0.0 5.9 6 0 0 6 6 6 4 Multicopper oxidase Cu-oxidase_2 PF07731.12 214120.1_49829001_1 - 5.9e-05 22.7 8.7 0.19 11.3 0.2 5.3 4 1 0 4 4 4 3 Multicopper oxidase 7tm_1 PF00001.19 214146.1_49823001_3 - 5.5e-53 179.8 20.0 7.3e-53 179.4 20.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2976 PF11190.6 214146.1_49823001_3 - 0.038 13.7 1.8 0.38 10.4 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) DUF2975 PF11188.6 214146.1_49823001_3 - 7.3 6.3 12.7 3.4 7.4 2.1 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2975) ADH_zinc_N PF00107.24 001034158.1_39726001_2 - 1.1e-26 93.1 0.1 1.7e-26 92.5 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 001034158.1_39726001_2 - 3e-25 88.1 0.4 5.4e-25 87.3 0.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.4 001034158.1_39726001_2 - 0.00067 20.6 0.0 0.0011 19.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.3 001034158.1_39726001_2 - 0.0011 18.3 0.0 0.0017 17.8 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus UDPG_MGDP_dh_N PF03721.12 001034158.1_39726001_2 - 0.008 15.6 0.1 0.012 15.0 0.1 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.19 001034158.1_39726001_2 - 0.057 12.6 0.2 0.093 11.9 0.2 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain O-FucT PF10250.7 001002278.1_45723001_1 - 2.1e-75 254.2 0.0 2.5e-75 254.0 0.0 1.0 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Mersacidin PF16934.3 001009231.1_22428001_1 - 3.9 7.2 9.4 10 5.8 9.4 1.8 1 0 0 1 1 1 0 Two-component Enterococcus faecalis cytolysin (EFC) Pkinase_Tyr PF07714.15 001009231.1_22428001_3 - 6.4e-105 350.0 0.0 9.2e-105 349.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001009231.1_22428001_3 - 4e-40 137.7 0.0 8.2e-26 90.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.4 001009231.1_22428001_3 - 4.5e-29 100.8 4.3 5.1e-08 33.3 0.0 5.8 5 1 0 5 5 5 4 Immunoglobulin domain I-set PF07679.14 001009231.1_22428001_3 - 2.3e-23 81.9 0.0 6.3e-06 26.0 0.0 6.2 5 1 0 5 5 5 4 Immunoglobulin I-set domain ig PF00047.23 001009231.1_22428001_3 - 8.8e-22 77.0 9.7 1.3e-13 50.7 0.0 6.9 5 2 0 5 5 5 2 Immunoglobulin domain Ig_2 PF13895.4 001009231.1_22428001_3 - 2.2e-18 66.2 1.6 1.7e-05 25.0 0.0 5.2 4 1 1 5 5 5 3 Immunoglobulin domain V-set PF07686.15 001009231.1_22428001_3 - 3.1e-05 23.9 13.6 1.1 9.4 0.1 7.4 6 4 1 8 8 8 2 Immunoglobulin V-set domain Izumo-Ig PF16706.3 001009231.1_22428001_3 - 0.025 14.5 0.0 3.3 7.7 0.0 3.4 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain C1-set PF07654.13 001009231.1_22428001_3 - 0.027 14.8 1.5 1.3 9.4 0.0 3.8 4 0 0 4 4 4 0 Immunoglobulin C1-set domain SR-25 PF10500.7 001009231.1_22428001_3 - 5.8 6.3 9.8 13 5.2 9.8 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein NGF PF00243.16 001009367.1_22422001_1 - 1e-50 170.6 2.8 1.4e-50 170.1 2.8 1.2 1 0 0 1 1 1 1 Nerve growth factor family Spaetzle PF16077.3 001009367.1_22422001_1 - 0.00029 21.1 0.4 0.00048 20.4 0.4 1.4 1 0 0 1 1 1 1 Spaetzle Lectin_C PF00059.19 001009074.1_39723001_1 - 6.7e-24 84.6 2.6 6.7e-24 84.6 2.6 1.9 2 0 0 2 2 2 1 Lectin C-type domain Sushi PF00084.18 001009074.1_39723001_1 - 2e-11 44.2 16.7 1.5e-07 31.7 3.5 3.2 2 1 1 3 3 3 2 Sushi repeat (SCR repeat) EGF PF00008.25 001009074.1_39723001_1 - 0.00029 20.9 10.5 0.00029 20.9 10.5 2.9 3 0 0 3 3 3 1 EGF-like domain hEGF PF12661.5 001009074.1_39723001_1 - 0.0015 19.0 6.6 0.014 15.9 6.6 2.9 1 0 0 1 1 1 1 Human growth factor-like EGF EGF_2 PF07974.11 001009074.1_39723001_1 - 0.0024 18.1 11.2 0.017 15.4 11.2 2.6 1 0 0 1 1 1 1 EGF-like domain EGF_3 PF12947.5 001009074.1_39723001_1 - 0.42 10.7 9.8 0.11 12.6 4.3 3.0 2 0 0 2 2 2 0 EGF domain Syntaxin PF00804.23 001009440.1_39522001_1 - 1.9e-64 216.9 18.9 1.9e-64 216.9 18.9 1.3 2 0 0 2 2 1 1 Syntaxin SNARE PF05739.17 001009440.1_39522001_1 - 4.8e-22 77.6 3.5 7e-22 77.0 1.3 2.4 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.4 001009440.1_39522001_1 - 2.9e-10 40.3 8.2 2.9e-10 40.3 8.2 2.5 1 1 1 2 2 2 1 Syntaxin-like protein AAA_13 PF13166.4 001009440.1_39522001_1 - 7e-05 21.6 15.6 8.9e-05 21.2 15.6 1.1 1 0 0 1 1 1 1 AAA domain GNVR PF13807.4 001009440.1_39522001_1 - 0.013 15.3 0.1 0.036 13.8 0.1 1.7 1 0 0 1 1 1 0 G-rich domain on putative tyrosine kinase Lzipper-MIP1 PF14389.4 001009440.1_39522001_1 - 0.014 15.5 0.5 0.014 15.5 0.5 2.7 2 1 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 FAD_binding_1 PF00667.18 001009440.1_39522001_1 - 0.026 14.0 1.3 0.056 12.9 1.3 1.5 1 0 0 1 1 1 0 FAD binding domain Baculo_PEP_C PF04513.10 001009440.1_39522001_1 - 0.059 13.3 3.3 0.42 10.5 0.3 2.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus RE_NgoFVII PF09565.8 001009440.1_39522001_1 - 0.084 12.0 9.4 0.03 13.5 6.5 1.6 1 1 0 1 1 1 0 NgoFVII restriction endonuclease DUF1910 PF08928.8 001009440.1_39522001_1 - 0.11 12.4 13.7 0.51 10.2 1.6 3.4 1 1 3 4 4 4 0 Domain of unknown function (DUF1910) MCPsignal PF00015.19 001009440.1_39522001_1 - 0.12 12.0 11.2 1 8.9 1.5 2.3 1 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain GlutR_dimer PF00745.18 001009440.1_39522001_1 - 0.14 12.4 12.7 1.2 9.4 0.4 3.3 2 1 2 4 4 3 0 Glutamyl-tRNAGlu reductase, dimerisation domain Acyl-CoA_dh_2 PF08028.9 001009440.1_39522001_1 - 0.16 12.1 0.9 0.24 11.5 0.2 1.7 2 1 0 2 2 1 0 Acyl-CoA dehydrogenase, C-terminal domain WXG100 PF06013.10 001009440.1_39522001_1 - 0.16 12.1 5.3 7.3 6.8 0.3 4.0 4 0 0 4 4 4 0 Proteins of 100 residues with WXG TolA_bind_tri PF16331.3 001009440.1_39522001_1 - 0.34 10.9 5.1 0.41 10.6 0.0 3.4 4 2 0 4 4 3 0 TolA binding protein trimerisation Sec34 PF04136.13 001009440.1_39522001_1 - 0.68 9.7 13.2 0.42 10.4 5.3 3.2 1 1 2 3 3 3 0 Sec34-like family DUF948 PF06103.9 001009440.1_39522001_1 - 0.86 9.8 8.9 4 7.6 1.4 4.0 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Filo_VP35 PF02097.13 001009440.1_39522001_1 - 0.93 8.3 5.4 1.2 8.0 0.5 2.1 2 0 0 2 2 2 0 Filoviridae VP35 Syntaxin-6_N PF09177.9 001009440.1_39522001_1 - 1.3 9.5 16.2 96 3.5 15.7 3.3 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Med9 PF07544.11 001009440.1_39522001_1 - 1.5 8.8 9.7 0.68 9.9 1.4 3.3 2 2 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Uso1_p115_C PF04871.11 001009440.1_39522001_1 - 1.9 8.7 22.3 0.82 9.9 8.7 3.2 2 1 1 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region YtxH PF12732.5 001009440.1_39522001_1 - 2 8.9 12.1 2.8 8.4 2.5 4.0 1 1 1 2 2 2 0 YtxH-like protein SIMPL PF04402.12 001009440.1_39522001_1 - 2.2 8.6 8.9 6.3 7.1 8.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF541) ETRAMP PF09716.8 001009440.1_39522001_1 - 4.2 7.4 7.3 2.2 8.3 1.0 2.7 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Herpes_UL25 PF01499.14 001009440.1_39522001_1 - 4.2 5.6 8.7 0.6 8.4 3.2 2.0 1 1 1 2 2 2 0 Herpesvirus UL25 family Wtap PF17098.3 001009440.1_39522001_1 - 4.6 7.0 14.9 0.33 10.7 1.0 3.4 3 1 0 3 3 3 0 WTAP/Mum2p family Laminin_II PF06009.10 001009440.1_39522001_1 - 5.6 6.8 13.0 1.3 8.9 4.6 2.7 2 1 0 2 2 2 0 Laminin Domain II DUF848 PF05852.9 001009440.1_39522001_1 - 5.7 6.9 17.1 0.23 11.5 5.1 3.0 1 1 1 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) FAM167 PF11652.6 001009440.1_39522001_1 - 5.9 7.3 10.5 1.9 8.9 0.4 3.4 2 1 0 2 2 2 0 FAM167 FGF PF00167.16 001009769.1_39521001_1 - 6.1e-43 145.8 0.0 7e-43 145.6 0.0 1.0 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.11 001009769.1_39521001_1 - 3.6e-06 27.0 0.1 0.011 15.8 0.0 1.6 1 1 1 2 2 2 2 Fascin domain IL1 PF00340.17 001009769.1_39521001_1 - 0.001 18.6 0.0 0.0015 18.1 0.0 1.3 1 0 0 1 1 1 1 Interleukin-1 / 18 LRR_8 PF13855.4 001009201.1_39523001_1 - 5.6e-35 118.8 18.1 6.4e-14 51.3 1.9 4.3 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 001009201.1_39523001_1 - 3.3e-15 55.7 19.4 7e-05 23.0 0.7 6.0 3 2 4 7 7 7 7 Leucine Rich repeats (2 copies) LRRNT PF01462.16 001009201.1_39523001_1 - 4.9e-13 48.2 8.4 3.5e-11 42.3 2.2 3.9 3 0 0 3 3 3 2 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 001009201.1_39523001_1 - 5.2e-10 39.0 7.7 0.00022 20.6 0.7 3.4 1 1 2 3 3 3 2 Leucine-rich repeat LRR_5 PF13306.4 001009201.1_39523001_1 - 1e-05 25.4 0.0 0.00031 20.6 0.0 2.6 1 1 2 3 3 3 2 Leucine rich repeats (6 copies) LRR_1 PF00560.31 001009201.1_39523001_1 - 0.0013 18.7 17.3 4.5 8.0 0.2 7.8 6 2 1 7 7 7 2 Leucine Rich Repeat LRR_6 PF13516.4 001009201.1_39523001_1 - 1.1 9.3 18.8 14 5.9 0.0 7.8 10 0 0 10 10 10 0 Leucine Rich repeat Ras PF00071.20 001013386.2_32927001_2 - 3.7e-22 78.5 0.0 6.8e-22 77.7 0.0 1.4 1 1 0 1 1 1 1 Ras family Roc PF08477.11 001013386.2_32927001_2 - 3.8e-05 23.8 0.0 0.00019 21.5 0.0 1.9 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.21 001013386.2_32927001_2 - 0.0011 18.9 0.0 0.0015 18.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.4 001013386.2_32927001_2 - 0.042 14.1 0.0 0.075 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.4 001013386.2_32927001_2 - 0.12 12.3 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain Arf PF00025.19 001013386.2_32927001_2 - 0.19 11.0 0.0 12 5.2 0.0 2.1 2 0 0 2 2 2 0 ADP-ribosylation factor family ATPase PF06745.11 001013386.2_32927001_2 - 0.27 10.4 0.0 0.4 9.8 0.0 1.1 1 0 0 1 1 1 0 KaiC Insulin PF00049.16 001045679.1_49821001_1 - 5.1e-07 30.5 1.8 7.3e-06 26.8 1.8 2.1 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family Ins_beta PF03488.12 001045679.1_49821001_1 - 0.00063 19.6 3.5 0.31 11.0 0.1 2.3 2 0 0 2 2 2 2 Nematode insulin-related peptide beta type RnaseA PF00074.18 001009132.1_39721001_1 - 1.1e-39 135.5 7.1 1.3e-39 135.3 7.1 1.0 1 0 0 1 1 1 1 Pancreatic ribonuclease Tr-sialidase_C PF11052.6 001009132.1_39721001_1 - 1.6 8.9 9.3 2.7 8.2 9.3 1.3 1 0 0 1 1 1 0 Trans-sialidase of Trypanosoma hydrophobic C-terminal Transthyretin PF00576.19 001009800.1_39522001_3 - 6.9e-20 71.7 0.0 9.5e-20 71.2 0.0 1.1 1 0 0 1 1 1 1 HIUase/Transthyretin family Neur_chan_LBD PF02931.21 001033933.1_39723001_1 - 4.4e-74 248.4 0.2 6.1e-74 248.0 0.2 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 001033933.1_39723001_1 - 3.9e-66 223.4 13.9 4.3e-51 174.1 9.6 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region CLCA PF08434.9 001032912.1_29626001_2 - 0 1212.4 0.1 0 1212.2 0.1 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel VWA_2 PF13519.4 001032912.1_29626001_2 - 2.8e-12 47.1 0.0 8.2e-12 45.6 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.26 001032912.1_29626001_2 - 6.3e-10 39.5 0.0 1.4e-09 38.4 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.12 001032912.1_29626001_2 - 0.0031 16.8 0.0 0.0061 15.9 0.0 1.4 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein DUF444 PF04285.10 001032912.1_29626001_2 - 0.088 11.7 0.1 0.25 10.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF444) Na_K-ATPase PF00287.16 001001258.1_49823001_1 - 7.8e-104 346.7 0.1 9.1e-104 346.5 0.1 1.0 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain Transthyretin PF00576.19 001009137.1_39722001_3 - 9.7e-19 68.0 0.0 1.3e-18 67.6 0.0 1.1 1 0 0 1 1 1 1 HIUase/Transthyretin family Frizzled PF01534.15 001044251.2_45727001_1 - 7.3e-145 481.9 3.2 9.1e-145 481.6 3.2 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.20 001044251.2_45727001_1 - 1.6e-35 122.0 2.8 2.9e-35 121.2 2.8 1.4 1 0 0 1 1 1 1 Fz domain PhaG_MnhG_YufB PF03334.12 001044251.2_45727001_1 - 0.43 10.7 4.4 0.46 10.6 2.2 2.2 2 0 0 2 2 2 0 Na+/H+ antiporter subunit 6PGD PF00393.17 001009467.2_39524001_2 - 1.3e-129 431.5 0.0 1.8e-129 431.1 0.0 1.2 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.13 001009467.2_39524001_2 - 1.7e-47 161.4 0.0 2.5e-47 160.9 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.4 001009467.2_39524001_2 - 0.042 14.0 0.1 0.12 12.5 0.1 1.8 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 7tm_2 PF00002.22 001009727.1_39523001_1 - 2.3e-78 262.8 18.9 3.1e-78 262.3 18.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 001009727.1_39523001_1 - 1.4e-12 47.6 1.1 2.9e-12 46.5 1.1 1.6 1 0 0 1 1 1 1 Hormone receptor domain DUF2976 PF11190.6 001009727.1_39523001_1 - 0.17 11.5 1.0 24 4.7 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) ITAM PF02189.13 001009417.1_39522001_2 - 4.8e-20 70.6 0.4 6.3e-06 26.2 0.0 3.4 3 0 0 3 3 3 3 Immunoreceptor tyrosine-based activation motif TCR_zetazeta PF11628.6 001009417.1_39522001_2 - 8.2e-18 63.6 0.8 1.4e-17 62.9 0.8 1.4 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 zeta chain IL5 PF02025.13 001009783.1_39522001_1 - 1e-61 206.0 0.6 1.3e-61 205.6 0.6 1.1 1 0 0 1 1 1 1 Interleukin 5 SRCR PF00530.16 213976.1_49827001_1 - 4.3e-250 810.0 127.1 6e-33 113.2 6.9 9.4 10 0 0 10 10 10 9 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.4 213976.1_49827001_1 - 2.2e-22 79.3 58.3 0.0004 20.7 0.4 9.6 9 0 0 9 9 9 8 Scavenger receptor cysteine-rich domain RHS PF03527.12 213976.1_49827001_1 - 0.014 15.0 11.0 5.8 6.6 0.2 6.2 6 0 0 6 6 6 0 RHS protein Shadoo PF14999.4 183147.2_32927001_1 - 8.6e-66 219.9 25.2 1.3e-65 219.4 25.2 1.3 1 0 0 1 1 1 1 Shadow of prion protein, neuroprotective DnaJ PF00226.29 001014204.1_45723001_2 - 1.3e-17 63.5 0.1 2.9e-17 62.4 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain TM2 PF05154.14 001014204.1_45723001_2 - 7.1e-08 32.5 11.7 7.1e-08 32.5 11.7 2.5 2 0 0 2 2 2 1 TM2 domain Holin_2-3 PF13272.4 001014204.1_45723001_3 - 0.073 13.2 0.1 0.12 12.6 0.1 1.2 1 0 0 1 1 1 0 Putative 2/3 transmembrane domain holin Filament PF00038.19 001008804.1_45724001_1 - 7.7e-115 383.6 36.5 9.8e-115 383.3 36.5 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 001008804.1_45724001_1 - 0.0054 16.7 4.4 0.0054 16.7 4.4 4.4 2 2 1 4 4 4 2 TPR/MLP1/MLP2-like protein ATG16 PF08614.9 001008804.1_45724001_1 - 0.0061 16.6 30.4 0.041 13.9 1.2 4.1 3 1 0 3 3 3 1 Autophagy protein 16 (ATG16) BRE1 PF08647.9 001008804.1_45724001_1 - 0.018 15.0 0.6 0.018 15.0 0.6 4.4 2 1 1 4 4 4 0 BRE1 E3 ubiquitin ligase Jnk-SapK_ap_N PF09744.7 001008804.1_45724001_1 - 0.024 14.7 34.7 0.31 11.1 12.1 3.9 1 1 3 4 4 4 0 JNK_SAPK-associated protein-1 Spc7 PF08317.9 001008804.1_45724001_1 - 0.025 13.3 34.6 0.0072 15.1 15.6 3.1 1 1 2 3 3 3 0 Spc7 kinetochore protein DUF4407 PF14362.4 001008804.1_45724001_1 - 0.083 12.1 21.6 0.027 13.7 3.7 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) Reo_sigmaC PF04582.10 001008804.1_45724001_1 - 0.21 10.8 11.3 3.8 6.7 6.2 3.1 1 1 1 3 3 3 0 Reovirus sigma C capsid protein DUF4618 PF15397.4 001008804.1_45724001_1 - 0.27 10.5 27.0 0.077 12.3 17.3 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) DivIC PF04977.13 001008804.1_45724001_1 - 0.36 10.5 29.1 1.1 9.0 3.5 5.9 4 2 1 6 6 6 0 Septum formation initiator Tox-ODYAM1 PF15642.4 001008804.1_45724001_1 - 0.65 8.8 10.8 0.13 11.1 6.5 1.6 1 1 0 1 1 1 0 Toxin in Odyssella and Amoebophilus DUF972 PF06156.11 001008804.1_45724001_1 - 1.4 9.5 30.1 0.34 11.4 0.4 5.5 2 1 4 6 6 6 0 Protein of unknown function (DUF972) DUF2203 PF09969.7 001008804.1_45724001_1 - 1.4 9.5 15.7 6 7.5 0.1 4.0 1 1 2 4 4 4 0 Uncharacterized conserved protein (DUF2203) Cep57_MT_bd PF06657.11 001008804.1_45724001_1 - 2.1 8.7 19.0 1.1 9.6 1.8 4.3 3 1 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 DUF724 PF05266.12 001008804.1_45724001_1 - 4.7 6.9 25.8 1.7 8.3 8.6 3.8 1 1 3 4 4 4 0 Protein of unknown function (DUF724) TolA_bind_tri PF16331.3 001008804.1_45724001_1 - 5.1 7.1 37.1 1.6 8.7 1.1 5.5 5 1 1 6 6 5 0 TolA binding protein trimerisation APG6 PF04111.10 001008804.1_45724001_1 - 6.7 5.9 36.5 3.2 6.9 6.0 2.9 2 1 1 3 3 3 0 Autophagy protein Apg6 DUF1664 PF07889.10 001008804.1_45724001_1 - 7.7 6.4 22.3 1.2 9.0 3.8 4.1 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) 7tm_1 PF00001.19 001001617.1_49823001_1 - 1.9e-32 112.4 16.8 8.3e-31 107.1 16.8 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Fringe PF02434.14 001012431.1_39722001_1 - 6.3e-112 373.0 0.0 7.2e-112 372.7 0.0 1.0 1 0 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.19 001012431.1_39722001_1 - 0.25 11.0 0.0 0.36 10.5 0.0 1.2 1 0 0 1 1 1 0 Galactosyltransferase Na_Pi_cotrans PF02690.13 001009450.1_39525001_2 - 1.4e-40 138.5 18.6 3.6e-25 88.6 6.2 2.4 2 0 0 2 2 2 2 Na+/Pi-cotransporter DUF2207 PF09972.7 001009450.1_39525001_2 - 2.6 6.6 4.1 21 3.6 0.1 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) IL3 PF02059.13 001009420.2_39522001_2 - 4.4e-42 142.7 0.4 5.4e-42 142.4 0.4 1.1 1 0 0 1 1 1 1 Interleukin-3 Fibrinogen_C PF00147.16 213808.1_49825001_3 - 2.4e-68 230.1 7.6 3.8e-68 229.5 7.6 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Spc29 PF17082.3 213808.1_49825001_3 - 0.017 14.8 1.4 0.017 14.8 1.4 2.6 1 1 1 2 2 2 0 Spindle Pole Component 29 DUF4239 PF14023.4 213808.1_49825001_3 - 1.3 8.6 6.9 1.5 8.4 6.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4239) SlyX PF04102.10 213808.1_49825001_3 - 5.3 7.6 23.3 0.32 11.5 5.6 3.1 1 1 2 3 3 3 0 SlyX DivIC PF04977.13 213808.1_49825001_3 - 6.5 6.5 18.7 0.18 11.4 3.5 3.3 1 1 3 4 4 4 0 Septum formation initiator PHF5 PF03660.12 138888.1_45722001_1 - 1e-48 163.7 13.9 1.6e-48 163.1 13.9 1.3 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.11 138888.1_45722001_1 - 1.2 6.8 9.1 1.5 6.5 9.1 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Septin PF00735.16 019375.1_45723001_2 - 4.4e-114 380.3 1.3 5.8e-114 379.9 1.3 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.21 019375.1_45723001_2 - 2.7e-08 33.8 0.0 5.1e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 019375.1_45723001_2 - 1.1e-06 28.5 2.4 1.1e-05 25.2 0.7 2.4 2 1 0 2 2 2 1 Protein of unknown function, DUF258 AIG1 PF04548.14 019375.1_45723001_2 - 2.4e-05 23.7 0.1 4.2e-05 22.8 0.1 1.5 1 0 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.25 019375.1_45723001_2 - 3.4e-05 23.3 0.7 0.013 14.9 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Roc PF08477.11 019375.1_45723001_2 - 0.00087 19.4 0.2 0.0018 18.3 0.2 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.21 019375.1_45723001_2 - 0.001 19.1 6.5 0.21 11.5 0.6 3.4 2 2 1 4 4 4 2 Dynamin family AAA_16 PF13191.4 019375.1_45723001_2 - 0.0015 18.8 0.0 0.0027 18.0 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.4 019375.1_45723001_2 - 0.0016 18.6 0.0 0.0042 17.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.25 019375.1_45723001_2 - 0.0021 18.4 0.2 0.0058 17.0 0.0 1.7 2 0 0 2 2 2 1 ABC transporter Ras PF00071.20 019375.1_45723001_2 - 0.0027 17.2 0.0 0.0064 16.0 0.0 1.7 1 0 0 1 1 1 1 Ras family FtsK_SpoIIIE PF01580.16 019375.1_45723001_2 - 0.0027 16.9 0.1 0.005 16.1 0.1 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_24 PF13479.4 019375.1_45723001_2 - 0.0081 15.8 0.0 0.26 10.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain G-alpha PF00503.18 019375.1_45723001_2 - 0.018 14.1 2.9 0.05 12.6 2.9 1.7 1 1 0 1 1 1 0 G-protein alpha subunit AAA_29 PF13555.4 019375.1_45723001_2 - 0.021 14.4 0.1 0.037 13.6 0.1 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain NB-ARC PF00931.20 019375.1_45723001_2 - 0.026 13.4 1.2 0.032 13.1 0.1 1.6 2 0 0 2 2 2 0 NB-ARC domain Sigma54_activat PF00158.24 019375.1_45723001_2 - 0.033 13.8 0.0 0.059 12.9 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain FeoB_N PF02421.16 019375.1_45723001_2 - 0.039 13.4 0.1 0.078 12.4 0.1 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_32 PF13654.4 019375.1_45723001_2 - 0.04 12.6 0.5 0.067 11.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.7 019375.1_45723001_2 - 0.041 13.5 0.1 1.4 8.5 0.0 2.8 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation IIGP PF05049.11 019375.1_45723001_2 - 0.05 12.5 0.5 0.095 11.6 0.1 1.6 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) DUF815 PF05673.11 019375.1_45723001_2 - 0.066 12.2 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DUF87 PF01935.15 019375.1_45723001_2 - 0.22 11.4 1.1 0.37 10.7 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function DUF87 IL8 PF00048.18 001009849.1_22421001_1 - 1.6e-18 66.5 0.1 1.9e-18 66.2 0.1 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like DsbB PF02600.14 001009849.1_22421001_1 - 0.047 14.0 0.1 0.058 13.7 0.1 1.1 1 0 0 1 1 1 0 Disulfide bond formation protein DsbB SH3_9 PF14604.4 213899.1_49824001_3 - 2e-09 37.0 0.0 4e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 213899.1_49824001_3 - 0.00022 20.6 0.0 0.00045 19.6 0.0 1.6 1 0 0 1 1 1 1 SH3 domain Wtap PF17098.3 213899.1_49824001_3 - 0.066 13.0 0.7 1.4 8.7 0.2 2.4 2 0 0 2 2 2 0 WTAP/Mum2p family SKI PF01202.20 213899.1_49824001_3 - 0.071 13.1 0.0 0.18 11.8 0.0 1.6 1 0 0 1 1 1 0 Shikimate kinase Zfx_Zfy_act PF04704.11 001009003.1_39726001_2 - 8.2e-147 488.5 21.5 8.2e-147 488.5 21.5 1.6 1 1 0 1 1 1 1 Zfx / Zfy transcription activation region zf-C2H2 PF00096.24 001009003.1_39726001_2 - 1.3e-39 132.4 115.7 9.6e-06 25.6 2.1 13.4 13 0 0 13 13 13 13 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001009003.1_39726001_2 - 8.8e-37 123.8 125.2 3.4e-08 33.5 1.2 14.0 14 0 0 14 14 14 12 Zinc-finger double domain zf-C2H2_4 PF13894.4 001009003.1_39726001_2 - 7.7e-29 97.7 111.3 0.00013 22.4 0.9 13.5 13 0 0 13 13 13 13 C2H2-type zinc finger zf-H2C2_5 PF13909.4 001009003.1_39726001_2 - 5.7e-26 89.8 100.9 4.1e-07 29.5 5.4 12.2 12 0 0 12 12 12 9 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.6 001009003.1_39726001_2 - 3.2e-11 43.1 76.0 0.034 14.4 0.0 12.4 13 0 0 13 13 13 6 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 001009003.1_39726001_2 - 3.8e-08 33.8 48.4 0.029 15.0 2.4 7.3 5 1 2 7 7 7 6 zinc-ribbon family zf-C2H2_6 PF13912.4 001009003.1_39726001_2 - 0.0021 17.8 2.5 0.0021 17.8 2.5 10.4 13 0 0 13 13 13 5 C2H2-type zinc finger zf-met PF12874.5 001009003.1_39726001_2 - 0.019 15.2 73.0 0.35 11.2 0.0 11.8 12 1 0 12 12 12 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.3 001009003.1_39726001_2 - 0.02 14.5 0.2 0.02 14.5 0.2 10.0 12 0 0 12 12 12 0 zinc-finger C2H2-type zf-H2C2_2 PF13465.4 011754.2_32928001_2 - 5.3e-134 431.1 135.5 6.5e-09 35.7 1.1 24.3 25 0 0 25 25 24 21 Zinc-finger double domain zf-C2H2 PF00096.24 011754.2_32928001_2 - 6.4e-112 360.1 152.0 7e-07 29.2 0.5 24.4 24 0 0 24 24 24 21 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 011754.2_32928001_2 - 4.8e-51 166.8 151.7 0.0083 16.7 0.3 23.9 25 0 0 25 25 23 20 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 011754.2_32928001_2 - 1.9e-21 75.8 82.2 0.0034 17.3 0.7 14.2 8 4 5 14 14 14 12 Zinc ribbon domain KRAB PF01352.25 011754.2_32928001_2 - 5.2e-20 70.7 0.3 9.5e-20 69.9 0.3 1.5 1 0 0 1 1 1 1 KRAB box DZR PF12773.5 011754.2_32928001_2 - 1.6e-06 27.9 93.1 1.6 8.7 5.0 12.3 4 2 2 6 6 2 1 Double zinc ribbon zinc_ribbon_15 PF17032.3 011754.2_32928001_2 - 9.1e-06 26.2 75.2 0.16 12.6 1.2 11.5 2 2 14 16 16 16 9 zinc-ribbon family C1_4 PF07975.10 011754.2_32928001_2 - 2.4e-05 24.4 88.0 0.23 11.6 1.7 13.5 7 4 7 14 14 13 5 TFIIH C1-like domain DUF3268 PF11672.6 011754.2_32928001_2 - 0.00029 21.0 72.7 0.49 10.6 1.1 11.9 4 3 6 14 14 14 9 zinc-finger-containing domain zf-C2H2_jaz PF12171.6 011754.2_32928001_2 - 0.0016 18.6 85.3 0.97 9.7 0.2 16.6 20 0 0 20 20 17 5 Zinc-finger double-stranded RNA-binding ADK_lid PF05191.12 011754.2_32928001_2 - 0.0016 18.3 57.0 0.0085 16.0 0.0 12.2 7 5 4 11 11 11 4 Adenylate kinase, active site lid zf-C2H2_6 PF13912.4 011754.2_32928001_2 - 0.019 14.8 112.3 0.15 11.9 0.7 19.8 21 0 0 21 21 21 0 C2H2-type zinc finger zf-C2H2_11 PF16622.3 011754.2_32928001_2 - 0.031 13.9 0.2 0.23 11.1 0.1 19.9 22 0 0 22 22 21 0 zinc-finger C2H2-type XPA_N PF01286.16 011754.2_32928001_2 - 0.19 11.6 67.5 12 5.9 0.0 19.1 21 0 0 21 21 21 0 XPA protein N-terminal Zn_ribbon_recom PF13408.4 011754.2_32928001_2 - 0.35 11.3 96.3 1.5 9.2 0.9 14.4 6 5 9 15 15 13 0 Recombinase zinc beta ribbon domain zf-trcl PF13451.4 011754.2_32928001_2 - 5.3 6.9 85.6 1 9.1 1.8 18.5 19 1 0 19 19 19 0 Probable zinc-ribbon domain zf-LYAR PF08790.9 011754.2_32928001_2 - 5.9 6.8 96.0 0.27 11.0 0.2 19.4 21 0 0 21 21 21 0 LYAR-type C2HC zinc finger O-FucT PF10250.7 001008982.1_39723001_1 - 1.6e-76 257.9 0.0 1.8e-76 257.7 0.0 1.0 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Arrestin_N PF00339.27 214345.1_49823001_1 - 2.1e-35 121.8 0.0 9.9e-34 116.4 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.20 214345.1_49823001_1 - 8.4e-17 61.7 0.1 1.5e-16 60.9 0.1 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain CBM49 PF09478.8 214345.1_49823001_1 - 0.00034 20.7 0.6 0.00057 20.0 0.6 1.3 1 0 0 1 1 1 1 Carbohydrate binding domain CBM49 AP3B1_C PF14796.4 214345.1_49823001_1 - 0.038 14.1 0.0 0.074 13.1 0.0 1.5 1 0 0 1 1 1 0 Clathrin-adaptor complex-3 beta-1 subunit C-terminal Carb_anhydrase PF00194.19 001009408.2_39523001_1 - 2.3e-53 181.2 0.0 2.7e-53 181.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase CDI PF02234.17 001009865.1_22422001_2 - 4.9e-19 68.2 0.2 7.4e-19 67.6 0.2 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor Septin PF00735.16 001014033.1_45724001_1 - 6.2e-96 320.8 1.0 6.2e-96 320.8 1.0 1.7 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.21 001014033.1_45724001_1 - 2.3e-05 24.3 0.0 6.4e-05 22.9 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.4 001014033.1_45724001_1 - 8.4e-05 22.7 0.6 0.0011 19.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.14 001014033.1_45724001_1 - 0.00016 21.5 0.1 0.01 15.6 0.0 2.8 2 1 1 3 3 3 1 Protein of unknown function, DUF258 AAA_16 PF13191.4 001014033.1_45724001_1 - 0.0002 21.6 0.0 0.00053 20.3 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain Roc PF08477.11 001014033.1_45724001_1 - 0.0022 18.1 0.0 0.0057 16.8 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 001014033.1_45724001_1 - 0.014 14.8 1.0 0.073 12.5 0.0 2.6 3 0 0 3 3 3 0 Ras family Atg14 PF10186.7 001014033.1_45724001_1 - 0.023 13.6 6.7 0.048 12.6 6.7 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ABC_tran PF00005.25 001014033.1_45724001_1 - 0.025 14.9 0.1 0.1 13.0 0.0 2.1 2 0 0 2 2 2 0 ABC transporter Dynamin_N PF00350.21 001014033.1_45724001_1 - 0.028 14.3 3.9 0.14 12.1 0.1 2.6 2 1 0 2 2 2 0 Dynamin family AIG1 PF04548.14 001014033.1_45724001_1 - 0.042 13.0 0.0 0.042 13.0 0.0 1.9 2 0 0 2 2 2 0 AIG1 family GTP_EFTU PF00009.25 001014033.1_45724001_1 - 0.054 12.9 2.2 1.7 8.0 0.1 2.8 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain Exonuc_VII_L PF02601.13 001014033.1_45724001_1 - 0.063 12.7 3.2 0.11 11.9 3.2 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit FtsK_SpoIIIE PF01580.16 001014033.1_45724001_1 - 0.063 12.5 0.6 0.12 11.5 0.0 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family H-kinase_dim PF02895.12 001014033.1_45724001_1 - 0.43 10.9 3.0 12 6.3 2.2 3.1 2 1 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain 7tm_1 PF00001.19 213834.1_49824001_1 - 3.1e-22 79.0 11.3 4.6e-22 78.4 11.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PTN_MK_C PF01091.16 214336.1_49822001_3 - 1.7e-26 92.2 9.1 1.7e-26 92.2 9.1 2.8 2 1 0 2 2 2 1 PTN/MK heparin-binding protein family, C-terminal domain PTN_MK_N PF05196.11 214336.1_49822001_3 - 7.1e-26 90.1 15.4 7.1e-26 90.1 15.4 2.5 3 1 0 3 3 3 1 PTN/MK heparin-binding protein family, N-terminal domain MFS_1 PF07690.14 001009302.1_22424001_3 - 1.2e-26 93.4 33.2 1.2e-26 93.4 33.2 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily UL45 PF05473.10 001009302.1_22424001_3 - 0.23 11.0 1.0 8.6 5.8 0.1 2.7 3 0 0 3 3 3 0 UL45 protein, carbohydrate-binding C-type lectin-like zf-H2C2_2 PF13465.4 001009089.1_39726001_2 - 2.1e-63 208.0 65.4 8e-10 38.6 1.1 9.3 9 0 0 9 9 9 8 Zinc-finger double domain zf-C2H2 PF00096.24 001009089.1_39726001_2 - 7.2e-37 123.7 65.2 1.3e-05 25.2 0.7 10.4 10 0 0 10 10 10 7 Zinc finger, C2H2 type KRAB PF01352.25 001009089.1_39726001_2 - 4.1e-24 83.8 2.0 1e-23 82.6 2.0 1.7 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 001009089.1_39726001_2 - 2.8e-22 77.3 52.5 0.013 16.2 0.6 9.7 9 0 0 9 9 8 7 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001009089.1_39726001_2 - 3.3e-16 58.7 49.0 0.0012 18.6 0.3 9.0 9 0 0 9 9 9 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001009089.1_39726001_2 - 2e-09 37.4 36.8 0.087 13.0 0.1 9.2 10 0 0 10 10 10 5 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 001009089.1_39726001_2 - 2.9e-06 27.2 42.0 0.033 14.2 5.4 5.8 2 1 5 7 7 7 6 Zinc ribbon domain zinc_ribbon_15 PF17032.3 001009089.1_39726001_2 - 0.043 14.4 31.0 0.42 11.3 1.7 4.7 1 1 2 4 4 4 0 zinc-ribbon family zf-BED PF02892.13 001009089.1_39726001_2 - 0.054 13.4 38.9 0.64 10.0 0.7 7.5 1 1 6 7 7 7 0 BED zinc finger C1_4 PF07975.10 001009089.1_39726001_2 - 0.059 13.5 32.0 0.73 10.0 1.8 6.0 1 1 5 7 7 7 0 TFIIH C1-like domain zf-C2H2_11 PF16622.3 001009089.1_39726001_2 - 0.06 13.0 31.8 0.74 9.5 0.2 7.7 8 0 0 8 8 8 0 zinc-finger C2H2-type XPA_N PF01286.16 001009089.1_39726001_2 - 0.22 11.5 35.8 9 6.3 0.2 8.1 8 0 0 8 8 8 0 XPA protein N-terminal HypA PF01155.17 001009089.1_39726001_2 - 1.1 9.2 24.5 1.5 8.7 2.6 4.2 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_Tnp_IS1595 PF12760.5 001009089.1_39726001_2 - 1.8 8.5 43.5 0.61 10.0 0.9 7.1 6 2 2 8 8 8 0 Transposase zinc-ribbon domain DZR PF12773.5 001009089.1_39726001_2 - 2.8 7.9 33.6 9.7e+03 -3.4 0.0 5.2 2 1 0 2 2 1 0 Double zinc ribbon DUF2175 PF09943.7 001009089.1_39726001_2 - 6.1 7.1 20.9 9.8 6.4 0.1 6.3 6 1 1 7 7 7 0 Uncharacterized protein conserved in archaea (DUF2175) PAP2 PF01569.19 201271.1_45723001_2 - 6e-20 71.3 1.5 1.3e-19 70.2 1.5 1.6 1 0 0 1 1 1 1 PAP2 superfamily Tissue_fac PF01108.15 001009748.1_39529001_2 - 1.7e-26 92.0 3.1 2.4e-12 46.5 0.0 2.5 2 0 0 2 2 2 2 Tissue factor Interfer-bind PF09294.8 001009748.1_39529001_2 - 3.8e-22 78.4 0.1 7.5e-22 77.5 0.1 1.5 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III PPV_E1_C PF00519.15 001009748.1_39529001_2 - 0.06 12.0 0.4 0.095 11.4 0.4 1.1 1 0 0 1 1 1 0 Papillomavirus helicase Integrin_beta PF00362.16 213908.1_49826001_2 - 2.6e-115 384.2 0.0 3.7e-115 383.7 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.9 213908.1_49826001_2 - 4.2e-17 61.4 0.8 7.2e-17 60.7 0.8 1.4 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.10 213908.1_49826001_2 - 1.2e-15 57.7 4.6 1.2e-15 57.7 4.6 3.6 3 1 1 4 4 4 1 Integrin beta tail domain PSI_integrin PF17205.1 213908.1_49826001_2 - 1.9e-14 53.1 7.0 1.9e-14 53.1 7.0 4.4 5 0 0 5 5 5 1 Integrin plexin domain EGF_2 PF07974.11 213908.1_49826001_2 - 8.1e-05 22.8 28.3 0.00074 19.7 12.3 6.8 6 2 1 7 7 7 3 EGF-like domain TGF_beta PF00019.18 001009458.1_39523001_1 - 1.4e-31 109.3 1.6 2.9e-31 108.3 1.6 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.16 001009458.1_39523001_1 - 9.5e-10 38.5 0.5 6.4e-09 35.8 0.5 2.1 1 1 0 1 1 1 1 TGF-beta propeptide F-box-like PF12937.5 001039018.1_45724001_2 - 3.9e-07 29.7 2.9 8.7e-07 28.6 2.9 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001039018.1_45724001_2 - 2.7e-05 23.8 1.4 0.00012 21.7 1.4 2.1 1 0 0 1 1 1 1 F-box domain Pkinase PF00069.23 001009039.1_39724001_1 - 8.5e-73 244.8 0.0 1.2e-72 244.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001009039.1_39724001_1 - 7.5e-46 156.4 0.0 1.2e-45 155.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.26 001009039.1_39724001_1 - 6.6e-20 71.1 0.0 2e-19 69.6 0.0 1.9 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.4 001009039.1_39724001_1 - 1.2e-07 31.3 0.2 0.00025 20.3 0.0 2.8 2 1 1 3 3 3 2 Kinase-like Spt5_N PF11942.6 001009039.1_39724001_1 - 0.0019 19.0 2.0 0.005 17.7 2.0 1.6 1 0 0 1 1 1 1 Spt5 transcription elongation factor, acidic N-terminal APH PF01636.21 001009039.1_39724001_1 - 0.0057 16.5 0.1 0.063 13.1 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family DSHCT PF08148.10 001009039.1_39724001_1 - 0.013 15.0 0.0 0.025 14.1 0.0 1.5 1 0 0 1 1 1 0 DSHCT (NUC185) domain Ribosomal_60s PF00428.17 001009039.1_39724001_1 - 0.031 14.7 2.3 0.031 14.7 2.3 2.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein Kdo PF06293.12 001009039.1_39724001_1 - 0.056 12.6 0.0 0.13 11.5 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family 7tm_1 PF00001.19 001009289.1_39525001_2 - 4.1e-32 111.3 23.2 6.1e-32 110.8 23.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GnHR_trans PF12369.6 001009289.1_39525001_2 - 2.5e-27 95.3 0.9 5e-27 94.4 0.9 1.5 1 0 0 1 1 1 1 Gonadotropin hormone receptor transmembrane region LRR_8 PF13855.4 001009289.1_39525001_2 - 2.5e-21 75.1 9.8 1.8e-06 27.4 0.0 5.2 2 2 3 5 5 5 5 Leucine rich repeat LRR_5 PF13306.4 001009289.1_39525001_2 - 2e-13 50.3 0.1 5.2e-07 29.6 0.0 2.3 1 1 0 2 2 2 2 Leucine rich repeats (6 copies) LRRNT PF01462.16 001009289.1_39525001_2 - 6.9e-06 25.5 3.0 6.9e-06 25.5 3.0 2.6 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_4 PF12799.5 001009289.1_39525001_2 - 9.3e-06 25.7 17.6 0.97 9.8 0.1 4.8 3 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001009289.1_39525001_2 - 0.0022 17.4 1.2 0.016 14.6 0.7 2.3 2 0 0 2 2 2 1 Leucine-rich repeat LRR_1 PF00560.31 001009289.1_39525001_2 - 4.8 7.9 9.6 39 5.1 0.2 5.9 5 1 0 5 5 5 0 Leucine Rich Repeat 7tm_1 PF00001.19 001009725.1_39523001_3 - 8e-49 166.1 22.1 1.2e-48 165.6 22.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001009725.1_39523001_3 - 4.3e-10 39.3 18.1 5.6e-10 38.9 18.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001009725.1_39523001_3 - 2.4e-07 30.2 20.6 4.1e-07 29.5 20.6 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001009725.1_39523001_3 - 7e-05 22.6 15.1 0.002 17.8 15.0 2.3 1 1 0 1 1 1 1 Olfactory receptor TctB PF07331.9 001009725.1_39523001_3 - 0.05 13.7 15.5 0.75 9.9 1.0 2.8 2 1 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family Git3 PF11710.6 001009725.1_39523001_3 - 1.6 8.3 25.8 0.062 12.9 15.7 2.3 1 1 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 I-set PF07679.14 001012436.1_39723001_1 - 3.6e-44 148.6 0.2 1.3e-15 57.1 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 001012436.1_39723001_1 - 5.5e-39 132.5 0.6 4e-14 52.9 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.23 001012436.1_39723001_1 - 1.5e-33 114.6 2.6 1.5e-14 53.8 0.1 3.8 3 1 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 001012436.1_39723001_1 - 2.3e-30 104.6 0.7 3.2e-11 43.3 0.0 3.5 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.15 001012436.1_39723001_1 - 2.9e-16 59.4 7.5 1.1e-07 31.8 0.2 5.3 3 3 1 4 4 4 4 Immunoglobulin V-set domain Izumo-Ig PF16706.3 001012436.1_39723001_1 - 2.3e-08 33.8 0.7 0.015 15.2 0.1 4.1 3 1 0 3 3 3 3 Izumo-like Immunoglobulin domain Ig_5 PF16681.3 001012436.1_39723001_1 - 8.6e-08 32.4 0.0 0.18 12.1 0.0 3.7 3 1 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set_CD47 PF08204.9 001012436.1_39723001_1 - 0.0014 18.4 1.1 0.3 10.9 0.3 3.1 3 1 0 3 3 3 1 CD47 immunoglobulin-like domain Ig_4 PF16680.3 001012436.1_39723001_1 - 0.0021 18.2 0.7 15 5.9 0.1 3.9 4 1 0 4 4 4 1 T-cell surface glycoprotein CD3 delta chain Pkinase PF00069.23 024000.1_45728001_1 - 2.1e-61 207.5 0.1 2.9e-61 207.0 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 024000.1_45728001_1 - 5.9e-22 78.1 0.0 8.7e-22 77.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 024000.1_45728001_1 - 0.00048 19.4 0.0 0.009 15.2 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.12 024000.1_45728001_1 - 0.16 11.2 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family V-set PF07686.15 214149.1_49822001_2 - 7.8e-08 32.3 0.0 1e-07 31.9 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain V-set_2 PF15910.3 214149.1_49822001_2 - 0.0016 18.4 0.0 0.0021 18.0 0.0 1.2 1 0 0 1 1 1 1 ICOS V-set domain Ig_3 PF13927.4 214149.1_49822001_2 - 0.018 15.5 0.2 0.033 14.7 0.2 1.5 1 1 0 1 1 1 0 Immunoglobulin domain I-set PF07679.14 214149.1_49822001_2 - 0.039 13.9 0.0 0.064 13.2 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain Ribosomal_S4e PF00900.18 001032987.1_32322001_1 - 1.4e-39 133.7 0.5 8.5e-39 131.2 0.5 2.1 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.3 001032987.1_32322001_1 - 9.4e-31 105.1 0.1 1.6e-30 104.3 0.1 1.4 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.10 001032987.1_32322001_1 - 2.6e-22 78.5 6.2 7.2e-22 77.1 6.2 1.8 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.23 001032987.1_32322001_1 - 1.2e-07 31.1 0.0 2e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 S4 domain KOW PF00467.27 001032987.1_32322001_1 - 6.9e-06 25.7 0.3 2.3e-05 24.0 0.3 2.0 1 0 0 1 1 1 1 KOW motif Sipho_tail PF05709.9 001032987.1_32322001_1 - 0.091 12.1 0.1 0.13 11.5 0.1 1.3 1 0 0 1 1 1 0 Phage tail protein Tissue_fac PF01108.15 001009342.1_39525001_1 - 4.2e-23 81.1 0.1 8.7e-23 80.1 0.1 1.5 1 0 0 1 1 1 1 Tissue factor Interfer-bind PF09294.8 001009342.1_39525001_1 - 6.1e-15 55.3 0.0 1.2e-14 54.4 0.0 1.5 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.19 001009342.1_39525001_1 - 0.11 12.7 0.2 0.27 11.5 0.0 1.8 2 0 0 2 2 2 0 Fibronectin type III domain Pox_A6 PF04924.10 001009342.1_39525001_1 - 0.21 10.4 0.2 0.31 9.8 0.2 1.1 1 0 0 1 1 1 0 Poxvirus A6 protein HMG_box PF00505.17 001032836.1_29622001_1 - 3.2e-25 88.2 6.7 5.1e-25 87.6 6.7 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 001032836.1_29622001_1 - 2.5e-07 31.1 6.3 5.5e-07 29.9 6.3 1.6 1 0 0 1 1 1 1 HMG-box domain Cep57_CLD PF14073.4 001032836.1_29622001_1 - 0.098 12.5 1.1 0.12 12.3 1.1 1.2 1 0 0 1 1 1 0 Centrosome localisation domain of Cep57 ITI_HC_C PF06668.10 213903.1_49827001_3 - 9.1e-71 237.3 0.1 1.9e-70 236.3 0.1 1.6 1 0 0 1 1 1 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus VIT PF08487.8 213903.1_49827001_3 - 1.8e-31 108.6 0.3 4.8e-31 107.2 0.3 1.8 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA PF00092.26 213903.1_49827001_3 - 6.3e-22 78.5 2.2 1.1e-21 77.8 2.2 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.4 213903.1_49827001_3 - 3.7e-16 59.3 0.0 7.7e-16 58.2 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.4 213903.1_49827001_3 - 1.4e-12 48.1 0.6 6.1e-12 46.0 0.1 2.3 3 0 0 3 3 3 1 von Willebrand factor type A domain VWA_CoxE PF05762.12 213903.1_49827001_3 - 0.00066 19.0 0.0 0.0011 18.2 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein SWIB PF02201.16 213903.1_49827001_3 - 0.045 13.5 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 SWIB/MDM2 domain DUF2201 PF09967.7 213903.1_49827001_3 - 0.097 12.7 0.0 0.25 11.4 0.0 1.7 1 0 0 1 1 1 0 VWA-like domain (DUF2201) P53 PF00870.16 001009294.1_22425001_1 - 4.5e-112 372.2 0.4 6.7e-112 371.6 0.4 1.2 1 0 0 1 1 1 1 P53 DNA-binding domain P53_tetramer PF07710.9 001009294.1_22425001_1 - 5.1e-18 64.0 1.7 9.3e-18 63.2 1.7 1.4 1 0 0 1 1 1 1 P53 tetramerisation motif P53_TAD PF08563.9 001009294.1_22425001_1 - 1.7e-11 43.1 5.9 1.7e-11 43.1 5.9 2.5 2 0 0 2 2 2 1 P53 transactivation motif adh_short PF00106.23 001009460.1_39524001_2 - 8e-44 149.3 0.0 1.1e-43 148.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001009460.1_39524001_2 - 3.3e-24 85.6 0.0 5.3e-24 84.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase WAP PF00095.19 001035225.1_39521001_1 - 4.5e-19 68.4 37.0 9.4e-10 38.6 10.9 2.1 2 0 0 2 2 2 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' Apolipoprotein PF01442.16 214398.1_49822001_3 - 1.2e-47 162.2 12.9 1.8e-47 161.7 12.9 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain ApoLp-III PF07464.9 214398.1_49822001_3 - 5.8e-07 29.6 5.4 0.032 14.2 0.1 2.9 1 1 2 3 3 3 3 Apolipophorin-III precursor (apoLp-III) YtxH PF12732.5 214398.1_49822001_3 - 1.7e-06 28.3 10.8 0.035 14.5 1.5 4.4 1 1 1 2 2 2 2 YtxH-like protein Baculo_PEP_C PF04513.10 214398.1_49822001_3 - 3e-05 23.9 0.8 0.78 9.7 0.0 3.2 3 0 0 3 3 3 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4455 PF14643.4 214398.1_49822001_3 - 3.3e-05 22.7 5.9 4e-05 22.4 5.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4455) DUF883 PF05957.11 214398.1_49822001_3 - 3.6e-05 24.1 10.9 0.41 11.1 0.1 3.9 2 1 3 5 5 4 3 Bacterial protein of unknown function (DUF883) DUF1640 PF07798.9 214398.1_49822001_3 - 0.00015 21.7 1.3 0.00051 20.0 0.3 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF1640) Exonuc_VII_L PF02601.13 214398.1_49822001_3 - 0.00037 20.0 4.4 0.00062 19.3 4.4 1.4 1 0 0 1 1 1 1 Exonuclease VII, large subunit Gp-FAR-1 PF05823.10 214398.1_49822001_3 - 0.0017 18.6 4.7 0.045 13.9 0.9 2.7 1 1 1 2 2 2 1 Nematode fatty acid retinoid binding protein (Gp-FAR-1) ApoO PF09769.7 214398.1_49822001_3 - 0.0036 17.1 1.2 2.4 8.0 0.0 2.7 2 1 0 2 2 2 1 Apolipoprotein O DUF1664 PF07889.10 214398.1_49822001_3 - 0.0055 16.6 0.9 0.36 10.7 0.5 2.7 1 1 2 3 3 3 2 Protein of unknown function (DUF1664) OmpH PF03938.12 214398.1_49822001_3 - 0.0055 16.6 18.7 0.0057 16.5 9.0 2.4 1 1 1 2 2 2 1 Outer membrane protein (OmpH-like) DUF948 PF06103.9 214398.1_49822001_3 - 0.0075 16.4 0.3 1.9 8.7 0.0 3.3 2 1 1 3 3 3 1 Bacterial protein of unknown function (DUF948) Atg14 PF10186.7 214398.1_49822001_3 - 0.0078 15.2 3.8 0.01 14.8 3.8 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Gp58 PF07902.9 214398.1_49822001_3 - 0.018 13.4 0.2 0.021 13.1 0.2 1.1 1 0 0 1 1 1 0 gp58-like protein Matrilin_ccoil PF10393.7 214398.1_49822001_3 - 0.019 14.7 7.5 2.1 8.2 0.1 4.0 4 0 0 4 4 3 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF2336 PF10098.7 214398.1_49822001_3 - 0.037 13.4 4.0 0.056 12.8 4.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2336) FlgN PF05130.10 214398.1_49822001_3 - 0.043 14.2 12.4 0.16 12.3 5.3 2.4 1 1 1 2 2 2 0 FlgN protein DUF4015 PF13200.4 214398.1_49822001_3 - 0.046 12.6 0.3 0.11 11.4 0.3 1.6 1 0 0 1 1 1 0 Putative glycosyl hydrolase domain DUF3584 PF12128.6 214398.1_49822001_3 - 0.066 10.6 11.0 0.085 10.2 11.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Prominin PF05478.9 214398.1_49822001_3 - 0.12 10.2 1.9 0.99 7.1 2.0 1.9 1 1 0 1 1 1 0 Prominin CREPT PF16566.3 214398.1_49822001_3 - 0.12 12.4 9.0 0.081 13.0 3.8 2.5 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour WXG100 PF06013.10 214398.1_49822001_3 - 0.13 12.4 6.4 0.56 10.3 0.2 3.8 1 1 3 4 4 4 0 Proteins of 100 residues with WXG AAA_13 PF13166.4 214398.1_49822001_3 - 0.14 10.6 3.0 0.21 10.1 3.0 1.3 1 0 0 1 1 1 0 AAA domain RRF PF01765.17 214398.1_49822001_3 - 0.21 11.4 7.0 11 5.8 3.5 2.7 1 1 2 3 3 3 0 Ribosome recycling factor DUF3618 PF12277.6 214398.1_49822001_3 - 0.25 11.5 9.9 3.6 7.8 0.0 4.5 4 1 1 5 5 5 0 Protein of unknown function (DUF3618) KMP11 PF03037.14 214398.1_49822001_3 - 0.3 11.8 5.0 0.74 10.5 2.4 2.3 1 1 1 2 2 2 0 Kinetoplastid membrane protein 11 Golgin_A5 PF09787.7 214398.1_49822001_3 - 0.34 10.2 10.2 0.69 9.2 9.7 1.7 1 1 0 1 1 1 0 Golgin subfamily A member 5 GrpE PF01025.17 214398.1_49822001_3 - 0.39 10.2 12.2 3.6e+02 0.6 12.2 2.4 1 1 0 1 1 1 0 GrpE DUF2884 PF11101.6 214398.1_49822001_3 - 0.39 10.0 4.7 2.4 7.5 4.8 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2884) SHE3 PF17078.3 214398.1_49822001_3 - 0.48 10.0 7.1 8.8 5.8 2.2 2.3 1 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 DUF1690 PF07956.9 214398.1_49822001_3 - 0.49 10.7 9.0 0.16 12.2 3.6 2.3 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) TipAS PF07739.11 214398.1_49822001_3 - 0.54 10.7 10.4 11 6.5 2.9 3.1 1 1 2 3 3 3 0 TipAS antibiotic-recognition domain AbiH PF14253.4 214398.1_49822001_3 - 0.59 9.8 2.6 0.72 9.5 2.3 1.3 1 1 0 1 1 1 0 Bacteriophage abortive infection AbiH RGS-like PF09128.9 214398.1_49822001_3 - 0.67 9.5 4.7 0.73 9.4 3.7 1.5 1 1 0 1 1 1 0 Regulator of G protein signalling-like domain Spectrin PF00435.19 214398.1_49822001_3 - 0.82 10.1 13.4 1.1 9.7 6.6 2.8 2 1 1 3 3 2 0 Spectrin repeat CENP-H PF05837.10 214398.1_49822001_3 - 0.83 10.0 8.0 4.3 7.6 0.8 2.5 1 1 1 2 2 2 0 Centromere protein H (CENP-H) KxDL PF10241.7 214398.1_49822001_3 - 0.84 9.8 9.1 6.7 6.9 0.6 3.6 1 1 3 4 4 4 0 Uncharacterized conserved protein APG6 PF04111.10 214398.1_49822001_3 - 0.92 8.7 8.2 1.4 8.1 8.2 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4407 PF14362.4 214398.1_49822001_3 - 1.2 8.3 7.1 2.4 7.3 7.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) PCRF PF03462.16 214398.1_49822001_3 - 1.2 8.9 8.8 0.92 9.2 4.2 2.1 1 1 1 2 2 2 0 PCRF domain FAM184 PF15665.3 214398.1_49822001_3 - 1.2 8.7 14.1 4.4 6.9 14.1 2.0 1 1 0 1 1 1 0 Family with sequence similarity 184, A and B Muted PF14942.4 214398.1_49822001_3 - 1.3 9.2 8.5 1.8 8.7 4.9 2.3 1 1 2 3 3 3 0 Organelle biogenesis, Muted-like protein MIF4G_like_2 PF09090.9 214398.1_49822001_3 - 1.5 8.0 6.5 37 3.5 6.5 2.1 1 1 0 1 1 1 0 MIF4G like JIP_LZII PF16471.3 214398.1_49822001_3 - 1.6 8.8 6.6 4.7 7.3 0.3 3.3 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II HisKA_3 PF07730.11 214398.1_49822001_3 - 1.7 9.1 9.9 11 6.5 1.7 3.5 1 1 2 3 3 3 0 Histidine kinase DUF4164 PF13747.4 214398.1_49822001_3 - 1.8 8.7 9.3 4 7.6 5.0 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4164) Ku_C PF03730.12 214398.1_49822001_3 - 1.9 9.1 7.3 17 6.0 3.6 3.0 1 1 2 3 3 3 0 Ku70/Ku80 C-terminal arm YojJ PF10372.7 214398.1_49822001_3 - 2.2 8.3 4.0 3.3 7.7 0.3 3.0 3 1 0 3 3 3 0 Bacterial membrane-spanning protein N-terminus Phage_Mu_Gam PF07352.10 214398.1_49822001_3 - 2.7 7.8 10.2 6.4 6.5 0.5 2.8 1 1 2 3 3 3 0 Bacteriophage Mu Gam like protein HIP1_clath_bdg PF16515.3 214398.1_49822001_3 - 4.4 7.9 15.4 17 6.0 0.5 2.9 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 AATF-Che1 PF13339.4 214398.1_49822001_3 - 4.7 7.8 8.2 4.5 7.8 1.8 2.6 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor IncA PF04156.12 214398.1_49822001_3 - 6.7 6.3 13.8 52 3.4 13.7 2.1 1 1 0 1 1 1 0 IncA protein FUSC PF04632.10 214398.1_49822001_3 - 7.7 4.8 8.0 27 3.0 8.2 1.5 1 1 0 1 1 1 0 Fusaric acid resistance protein family O-FucT PF10250.7 001008983.1_39723001_1 - 7.1e-68 229.5 0.0 8.5e-68 229.2 0.0 1.1 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase IL8 PF00048.18 001032855.1_29621001_1 - 1.4e-23 82.7 0.8 1.4e-23 82.7 0.8 1.5 2 0 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like Hormone_1 PF00103.18 001009337.1_22422001_1 - 8.5e-46 156.3 0.0 9.7e-46 156.1 0.0 1.0 1 0 0 1 1 1 1 Somatotropin hormone family DUF3678 PF12435.6 001009222.1_22427001_2 - 2 7.6 4.0 2.3 7.4 1.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) Glyco_hydro_38C PF07748.11 001009222.1_22427001_3 - 1.5e-102 343.8 0.0 1.9e-102 343.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Glyco_hydro_38 PF01074.20 001009222.1_22427001_3 - 3.6e-93 311.9 2.4 5.6e-93 311.3 2.4 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Alpha-mann_mid PF09261.9 001009222.1_22427001_3 - 2.7e-20 72.4 0.0 6.1e-20 71.2 0.0 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain Ribosomal_S4e PF00900.18 001032988.1_32322001_1 - 8.8e-40 134.3 0.7 5.2e-39 131.9 0.6 2.1 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.3 001032988.1_32322001_1 - 8.5e-31 105.2 0.1 1.6e-30 104.3 0.1 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.10 001032988.1_32322001_1 - 2.6e-22 78.5 6.2 7.2e-22 77.1 6.2 1.8 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.23 001032988.1_32322001_1 - 4.4e-06 26.2 0.0 8.1e-06 25.3 0.0 1.5 1 0 0 1 1 1 1 S4 domain KOW PF00467.27 001032988.1_32322001_1 - 1e-05 25.2 0.2 4e-05 23.3 0.2 2.1 1 0 0 1 1 1 1 KOW motif Crystallin PF00525.16 001012457.2_39522001_3 - 9.7e-30 102.4 7.2 1.6e-29 101.7 7.2 1.4 1 0 0 1 1 1 1 Alpha crystallin A chain, N terminal HSP20 PF00011.19 001012457.2_39522001_3 - 1.5e-24 85.9 0.1 1.8e-24 85.6 0.1 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Xlink PF00193.15 001034170.1_39728001_1 - 5.2e-60 199.7 0.2 1.4e-29 102.2 0.0 3.2 3 0 0 3 3 3 2 Extracellular link domain Lectin_C PF00059.19 001034170.1_39728001_1 - 3.5e-24 85.5 5.4 7e-23 81.3 0.9 3.4 3 0 0 3 3 3 1 Lectin C-type domain Sushi PF00084.18 001034170.1_39728001_1 - 3.2e-11 43.6 0.3 1.1e-10 41.8 0.3 2.0 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) V-set PF07686.15 001034170.1_39728001_1 - 3e-10 40.1 0.0 6e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain EGF PF00008.25 001034170.1_39728001_1 - 1.3e-09 38.0 28.8 1.5e-05 25.1 11.6 2.9 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.5 001034170.1_39728001_1 - 1.8e-05 25.1 4.3 1.8e-05 25.1 4.3 4.6 3 0 0 3 3 3 2 Human growth factor-like EGF Ig_3 PF13927.4 001034170.1_39728001_1 - 0.028 14.9 0.0 0.17 12.4 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin domain EGF_2 PF07974.11 001034170.1_39728001_1 - 0.13 12.6 34.7 0.29 11.4 12.9 3.5 3 0 0 3 3 3 0 EGF-like domain SelP_N PF04592.12 001034170.1_39728001_1 - 9.5 5.4 20.6 15 4.7 20.6 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PDZ PF00595.22 001001630.1_49823001_1 - 8.6e-17 61.1 0.2 1.2e-16 60.7 0.2 1.2 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001001630.1_49823001_1 - 1.1e-06 28.8 0.0 1.6e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 PDZ domain Neur_chan_memb PF02932.14 001034094.1_39723001_1 - 6.5e-86 288.1 1.9 8.5e-86 287.7 1.9 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.21 001034094.1_39723001_1 - 4.6e-77 258.2 2.8 6.7e-77 257.6 2.8 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF1286 PF06939.9 001034094.1_39723001_1 - 0.54 10.4 7.0 0.75 10.0 4.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1286) DUF2417 PF10329.7 001034094.1_39723001_1 - 9.4 5.4 13.7 6.7 5.9 10.4 2.1 2 0 0 2 2 2 0 Region of unknown function (DUF2417) IL4 PF00727.16 001011714.1_39721001_1 - 3.6e-49 165.4 5.0 4.4e-49 165.2 5.0 1.1 1 0 0 1 1 1 1 Interleukin 4 Mannosyl_trans3 PF11051.6 001011714.1_39721001_1 - 0.032 13.4 0.0 0.04 13.1 0.0 1.2 1 0 0 1 1 1 0 Mannosyltransferase putative TspO_MBR PF03073.13 001009747.1_39522001_1 - 8.1e-44 148.8 12.1 9.8e-44 148.6 12.1 1.1 1 0 0 1 1 1 1 TspO/MBR family Phos_pyr_kin PF08543.10 001009220.1_39522001_1 - 1.6e-17 63.6 0.0 2.8e-17 62.8 0.0 1.3 1 1 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.22 001009220.1_39522001_1 - 3e-09 36.5 0.0 1.3e-08 34.4 0.0 1.9 1 1 0 1 1 1 1 pfkB family carbohydrate kinase HpcH_HpaI PF03328.12 001009220.1_39522001_1 - 0.011 14.8 0.0 0.031 13.3 0.0 1.7 1 0 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family SRR1 PF07985.10 001009220.1_39522001_1 - 0.075 13.0 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 SRR1 Aldo_ket_red PF00248.19 001001539.2_49822001_2 - 2.3e-57 194.3 0.0 3.1e-57 193.8 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Ig_5 PF16681.3 001009418.2_39523001_1 - 2.7e-35 120.5 1.7 4.1e-35 119.9 1.7 1.3 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 001009418.2_39523001_1 - 6.2e-19 68.0 1.7 1.1e-18 67.3 1.7 1.3 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 delta chain ITAM PF02189.13 001009418.2_39523001_1 - 3.9e-05 23.7 0.4 7.1e-05 22.9 0.4 1.5 1 0 0 1 1 1 1 Immunoreceptor tyrosine-based activation motif Ig_3 PF13927.4 001009418.2_39523001_1 - 0.012 16.1 0.1 0.023 15.1 0.1 1.5 1 0 0 1 1 1 0 Immunoglobulin domain CUB PF00431.18 001025210.1_49822001_2 - 1.4e-16 60.6 0.0 1.9e-16 60.3 0.0 1.1 1 0 0 1 1 1 1 CUB domain IL4 PF00727.16 001009313.2_39522001_2 - 9.8e-43 144.7 2.7 1.2e-42 144.4 2.7 1.1 1 0 0 1 1 1 1 Interleukin 4 Serpin PF00079.18 001009799.2_39523001_2 - 1.1e-119 400.0 0.5 1.2e-119 399.8 0.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF1266 PF06889.9 001009799.2_39523001_2 - 0.0024 17.8 0.0 0.0048 16.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1266) AAA_13 PF13166.4 001009799.2_39523001_2 - 0.0056 15.3 0.3 0.0074 14.9 0.3 1.1 1 0 0 1 1 1 1 AAA domain Lys PF00062.18 001009797.1_39522001_3 - 4.8e-54 181.7 7.8 7.4e-54 181.1 7.8 1.2 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family Cast PF10174.7 170787.2_45726001_1 - 0 1140.1 150.6 9.1e-177 589.5 58.2 2.0 1 1 1 2 2 2 2 RIM-binding protein of the cytomatrix active zone IncA PF04156.12 170787.2_45726001_1 - 1.3e-07 31.5 27.0 1.3e-07 31.5 27.0 7.6 2 2 4 7 7 7 2 IncA protein PKcGMP_CC PF16808.3 170787.2_45726001_1 - 0.00044 19.9 1.1 0.00044 19.9 1.1 12.3 13 1 0 14 14 14 2 Coiled-coil N-terminus of cGMP-dependent protein kinase HMMR_N PF15905.3 170787.2_45726001_1 - 0.00095 18.6 28.4 0.00095 18.6 28.4 5.8 1 1 4 5 5 5 1 Hyaluronan mediated motility receptor N-terminal Reo_sigmaC PF04582.10 170787.2_45726001_1 - 0.002 17.4 7.3 0.002 17.4 7.3 5.6 1 1 4 6 6 6 2 Reovirus sigma C capsid protein ATG16 PF08614.9 170787.2_45726001_1 - 0.0052 16.9 19.1 0.0052 16.9 19.1 9.2 1 1 9 10 10 10 4 Autophagy protein 16 (ATG16) HIP1_clath_bdg PF16515.3 170787.2_45726001_1 - 0.014 15.8 18.1 0.014 15.8 18.1 11.3 2 1 8 11 11 11 0 Clathrin-binding domain of Huntingtin-interacting protein 1 MHC_I_3 PF16497.3 001009423.1_39523001_2 - 1.4e-71 240.0 0.0 1.7e-71 239.6 0.0 1.1 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001009423.1_39523001_2 - 3e-12 46.7 0.0 5e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001009423.1_39523001_2 - 0.023 15.1 0.2 0.36 11.3 0.0 2.2 1 1 0 2 2 2 0 Immunoglobulin domain ig PF00047.23 001009423.1_39523001_2 - 0.034 14.2 0.0 0.31 11.1 0.0 2.1 1 1 1 2 2 2 0 Immunoglobulin domain Filament PF00038.19 001004131.1_45723001_1 - 2.2e-109 365.7 13.5 2.7e-109 365.4 13.5 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 001004131.1_45723001_1 - 0.0055 16.6 0.1 0.0055 16.6 0.1 3.6 3 1 0 3 3 3 1 TPR/MLP1/MLP2-like protein Lzipper-MIP1 PF14389.4 001004131.1_45723001_1 - 0.015 15.4 12.1 1.4 9.1 5.1 3.7 3 1 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 DUF3153 PF11353.6 001004131.1_45723001_1 - 0.029 13.8 1.5 0.3 10.5 0.1 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF3153) HXXSHH PF07586.9 001004131.1_45723001_1 - 0.051 13.0 0.0 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) SAA PF00277.16 001004131.1_45723001_1 - 0.064 13.7 0.7 0.39 11.1 0.1 2.2 2 0 0 2 2 2 0 Serum amyloid A protein DUF4407 PF14362.4 001004131.1_45723001_1 - 0.13 11.4 16.7 4.5 6.4 0.1 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) SPATA1_C PF15743.3 001004131.1_45723001_1 - 0.13 12.1 13.9 0.15 12.0 0.0 3.4 3 1 1 4 4 4 0 Spermatogenesis-associated C-terminus DUF972 PF06156.11 001004131.1_45723001_1 - 0.17 12.4 10.4 14 6.3 0.0 4.8 3 1 2 5 5 5 0 Protein of unknown function (DUF972) Jnk-SapK_ap_N PF09744.7 001004131.1_45723001_1 - 0.27 11.3 24.1 0.23 11.5 3.6 4.1 2 1 1 4 4 4 0 JNK_SAPK-associated protein-1 FlxA PF14282.4 001004131.1_45723001_1 - 0.4 10.5 19.5 0.25 11.2 4.5 4.2 2 2 2 4 4 4 0 FlxA-like protein DUF1664 PF07889.10 001004131.1_45723001_1 - 0.52 10.2 8.5 5 7.0 0.9 4.1 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) HMMR_N PF15905.3 001004131.1_45723001_1 - 1.1 8.5 18.0 0.7 9.2 7.8 2.6 2 2 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal BLOC1_2 PF10046.7 001004131.1_45723001_1 - 3 8.1 9.3 21 5.4 0.1 4.2 2 1 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Insulin PF00049.16 001009317.1_22422001_1 - 5e-12 46.5 2.9 1.1e-11 45.4 2.9 1.6 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family VGCC_beta4Aa_N PF12052.6 001009317.1_22422001_1 - 0.038 14.0 1.2 0.081 12.9 1.2 1.5 1 0 0 1 1 1 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal FTCD_N PF07837.10 214275.1_49824001_1 - 1.1e-73 246.6 0.0 1.9e-73 245.9 0.0 1.4 1 0 0 1 1 1 1 Formiminotransferase domain, N-terminal subdomain FTCD PF02971.12 214275.1_49824001_1 - 5.4e-68 227.6 0.0 2.3e-67 225.5 0.0 1.9 2 0 0 2 2 2 1 Formiminotransferase domain FTCD_C PF04961.10 214275.1_49824001_1 - 7.1e-66 221.3 1.1 1.2e-65 220.6 1.1 1.4 1 0 0 1 1 1 1 Formiminotransferase-cyclodeaminase KfrA_N PF11740.6 214275.1_49824001_1 - 7.6 7.1 9.1 0.46 11.0 1.4 2.7 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term RnaseA PF00074.18 001009107.1_39721001_1 - 6.1e-41 139.6 6.4 7e-41 139.4 6.4 1.0 1 0 0 1 1 1 1 Pancreatic ribonuclease DUF3079 PF11278.6 001009107.1_39721001_1 - 0.012 15.3 0.8 2.1 8.1 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3079) p450 PF00067.20 138512.1_45724001_1 - 2e-157 524.5 0.1 2.3e-157 524.3 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 PAD PF03068.13 001009791.1_39525001_2 - 1.2e-166 554.4 0.0 1.5e-166 554.0 0.0 1.1 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) PAD_M PF08527.8 001009791.1_39525001_2 - 1.4e-59 200.2 0.0 2.5e-59 199.3 0.0 1.4 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) middle domain PAD_N PF08526.8 001009791.1_39525001_2 - 3.1e-31 107.9 0.1 6e-31 107.0 0.1 1.5 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) N-terminal domain TCR_zetazeta PF11628.6 001001265.1_49822001_2 - 4.6e-16 58.0 3.3 8.3e-16 57.2 3.3 1.4 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 zeta chain ITAM PF02189.13 001001265.1_49822001_2 - 9.1e-06 25.7 0.1 1.7e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 Immunoreceptor tyrosine-based activation motif MAP17 PF15807.3 001001769.1_49822001_1 - 4e-35 120.7 0.0 5.8e-35 120.1 0.0 1.2 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 NfeD PF01957.16 001001769.1_49822001_1 - 0.029 14.7 0.3 0.044 14.0 0.3 1.2 1 0 0 1 1 1 0 NfeD-like C-terminal, partner-binding P19Arf_N PF07392.10 001032973.1_32322001_2 - 4.9e-23 81.2 9.7 1.4e-22 79.8 9.7 1.8 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus Ank_4 PF13637.4 001032973.1_32322001_3 - 1.3e-05 25.5 0.0 0.12 12.8 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.4 001032973.1_32322001_3 - 6.5e-05 23.1 0.1 0.0001 22.4 0.1 1.3 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.5 001032973.1_32322001_3 - 0.03 14.8 0.0 0.056 13.9 0.0 1.4 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Band_7 PF01145.23 001042381.1_39723001_1 - 6.5e-23 81.5 0.1 6.5e-23 81.5 0.1 3.0 2 1 0 2 2 2 1 SPFH domain / Band 7 family Flot PF15975.3 001042381.1_39723001_1 - 1.7e-08 34.5 6.5 1.7e-08 34.5 6.5 4.0 2 2 1 3 3 3 1 Flotillin HLH PF00010.24 001009785.1_39522001_3 - 8.3e-17 60.8 0.1 1.6e-16 59.8 0.1 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF2028 PF09667.8 001009785.1_39522001_3 - 0.21 11.4 0.0 2.1 8.1 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF2028) Basic PF01586.14 001009390.1_39525001_1 - 1.7e-29 102.7 0.3 3.9e-29 101.5 0.3 1.6 1 0 0 1 1 1 1 Myogenic Basic domain Myf5 PF12232.6 001009390.1_39525001_1 - 5.2e-25 87.9 5.0 1.1e-24 86.8 5.0 1.6 1 0 0 1 1 1 1 Myogenic determination factor 5 HLH PF00010.24 001009390.1_39525001_1 - 3.2e-14 52.5 2.3 5.4e-14 51.7 2.3 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain 7tm_1 PF00001.19 001012637.1_39723001_1 - 4.9e-53 180.0 11.3 6.2e-53 179.6 11.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001012637.1_39723001_1 - 1.6e-14 53.7 11.4 2.1e-14 53.4 11.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001012637.1_39723001_1 - 0.00024 20.4 8.0 0.00024 20.4 8.0 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001012637.1_39723001_1 - 0.0043 16.7 13.4 0.0091 15.6 13.4 1.6 1 1 0 1 1 1 1 Olfactory receptor Asp PF00026.21 001001536.2_49823001_1 - 4.1e-113 377.8 0.2 4.8e-113 377.6 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001001536.2_49823001_1 - 8.5e-16 58.6 13.3 1.8e-09 38.0 0.2 3.6 3 1 1 4 4 4 2 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001001536.2_49823001_1 - 3.5e-13 49.0 1.5 6.8e-13 48.1 1.5 1.5 1 0 0 1 1 1 1 A1 Propeptide NGF PF00243.16 001009828.1_22422001_1 - 1.1e-47 160.8 1.7 1.5e-47 160.3 1.7 1.2 1 0 0 1 1 1 1 Nerve growth factor family Spaetzle PF16077.3 001009828.1_22422001_1 - 0.00044 20.5 0.4 0.00065 20.0 0.4 1.3 1 0 0 1 1 1 1 Spaetzle ICAM_N PF03921.12 001009946.1_39724001_1 - 1.8e-40 136.4 0.3 1.5e-39 133.4 0.1 2.3 2 0 0 2 2 2 1 Intercellular adhesion molecule (ICAM), N-terminal domain Ig_2 PF13895.4 001009946.1_39724001_1 - 2.7e-17 62.7 0.9 0.0034 17.6 0.1 5.3 5 0 0 5 5 5 4 Immunoglobulin domain Ig_3 PF13927.4 001009946.1_39724001_1 - 1.5e-07 31.8 6.9 0.79 10.3 0.0 5.5 5 1 0 5 5 5 3 Immunoglobulin domain ig PF00047.23 001009946.1_39724001_1 - 1e-05 25.5 6.2 0.93 9.6 0.1 6.3 7 0 0 7 7 7 1 Immunoglobulin domain C2-set_2 PF08205.10 001009946.1_39724001_1 - 0.0022 17.9 6.7 0.13 12.3 0.0 4.4 5 1 0 6 6 6 2 CD80-like C2-set immunoglobulin domain I-set PF07679.14 001009946.1_39724001_1 - 0.0031 17.4 0.8 1.4 8.9 0.1 4.6 5 1 0 5 5 5 1 Immunoglobulin I-set domain Adhes-Ig_like PF09085.8 001009946.1_39724001_1 - 0.029 14.4 2.6 2 8.5 0.1 3.9 3 1 1 4 4 4 0 Adhesion molecule, immunoglobulin-like V-set PF07686.15 001009946.1_39724001_1 - 0.33 11.0 4.5 70 3.5 0.0 4.6 5 0 0 5 5 5 0 Immunoglobulin V-set domain DUF302 PF03625.12 001009946.1_39724001_3 - 0.17 11.6 0.0 0.31 10.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF302 Integrin_beta PF00362.16 001009485.1_39526001_2 - 3e-116 387.3 0.0 4.4e-116 386.7 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.9 001009485.1_39526001_2 - 4.9e-16 58.0 0.6 8.2e-16 57.3 0.6 1.4 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.10 001009485.1_39526001_2 - 2.5e-15 56.6 1.5 2.5e-15 56.6 1.5 4.0 4 1 1 5 5 5 1 Integrin beta tail domain PSI_integrin PF17205.1 001009485.1_39526001_2 - 9.1e-15 54.1 8.9 9.1e-15 54.1 8.9 4.5 5 0 0 5 5 5 1 Integrin plexin domain EGF_2 PF07974.11 001009485.1_39526001_2 - 7.8e-07 29.2 91.8 0.00022 21.4 11.5 6.6 5 2 1 6 6 6 4 EGF-like domain Ldh_1_N PF00056.21 001034096.1_39724001_3 - 2.2e-50 170.3 0.7 3.1e-50 169.8 0.7 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 001034096.1_39724001_3 - 5.5e-24 84.8 0.0 1.1e-23 83.9 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Pyr_redox_2 PF07992.12 001034096.1_39724001_3 - 0.016 14.3 0.0 0.026 13.7 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Glyco_hydro_4 PF02056.14 001034096.1_39724001_3 - 0.04 13.3 0.7 0.09 12.2 0.0 1.8 2 0 0 2 2 2 0 Family 4 glycosyl hydrolase Sugar_tr PF00083.22 001009451.1_39525001_1 - 6.8e-138 460.2 21.1 7.9e-138 460.0 21.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001009451.1_39525001_1 - 2.5e-20 72.6 26.7 2.3e-19 69.4 20.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_2_1 PF04971.10 001009451.1_39525001_1 - 0.14 12.1 2.7 23 4.9 0.1 3.4 3 0 0 3 3 3 0 Bacteriophage P21 holin S TTL PF03133.13 001004041.1_49824001_2 - 1.2e-71 241.2 0.0 3.6e-71 239.5 0.0 1.7 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.4 001004041.1_49824001_2 - 1.4e-06 27.7 0.1 1.4e-05 24.4 0.0 2.2 2 1 0 2 2 2 1 YheC/D like ATP-grasp ATP-grasp_3 PF02655.12 001004041.1_49824001_2 - 0.17 11.8 0.0 1.2 9.0 0.0 2.0 2 0 0 2 2 2 0 ATP-grasp domain AMP-binding PF00501.26 023104.1_45727001_1 - 1.6e-43 148.8 0.0 2.4e-43 148.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.3 023104.1_45727001_1 - 8.7e-10 38.2 2.8 1.1e-09 37.9 0.9 2.1 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus GHMP_kinases_N PF00288.24 023104.1_45727001_2 - 2.6 8.2 5.1 0.35 11.0 0.5 1.9 2 0 0 2 2 2 0 GHMP kinases N terminal domain IL4 PF00727.16 001008993.1_39721001_1 - 3.5e-34 117.2 6.3 5e-31 107.1 6.3 2.1 1 1 0 1 1 1 1 Interleukin 4 CNOT1_TTP_bind PF16417.3 001008993.1_39721001_1 - 0.049 12.7 0.3 0.14 11.2 0.0 1.8 2 0 0 2 2 2 0 CCR4-NOT transcription complex subunit 1 TTP binding domain Mannosyl_trans3 PF11051.6 001008993.1_39721001_1 - 0.058 12.6 0.0 0.074 12.2 0.0 1.1 1 0 0 1 1 1 0 Mannosyltransferase putative DUF4381 PF14316.4 001008993.1_39721001_1 - 0.12 12.4 0.1 0.46 10.6 0.0 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4381) p450 PF00067.20 001009052.1_39724001_1 - 6.9e-142 473.3 0.0 8.4e-142 473.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Aminotran_4 PF01063.17 001009444.1_39524001_3 - 1.3e-29 103.6 0.0 1.9e-29 103.0 0.0 1.3 1 0 0 1 1 1 1 Amino-transferase class IV IL8 PF00048.18 001034082.1_39721001_1 - 1.3e-24 86.0 0.5 1.6e-24 85.6 0.5 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like MHC_I PF00129.16 001009101.1_39723001_1 - 1.4e-43 148.4 0.6 2e-43 147.9 0.6 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001009101.1_39723001_1 - 5.5e-14 52.3 0.0 1e-13 51.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.3 001009101.1_39723001_1 - 2.8e-09 36.6 0.2 4.2e-09 36.0 0.2 1.3 1 0 0 1 1 1 1 MHC-I family domain Ig_3 PF13927.4 001009101.1_39723001_1 - 0.00024 21.5 0.0 0.00095 19.6 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 001009101.1_39723001_1 - 0.00038 20.6 0.0 0.00077 19.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain DUF912 PF06024.10 001009101.1_39723001_1 - 0.046 13.9 0.0 0.085 13.0 0.0 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) ig PF00047.23 001009101.1_39723001_1 - 0.062 13.3 0.0 0.16 12.0 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain SKG6 PF08693.8 001009101.1_39723001_1 - 0.13 11.6 3.4 0.24 10.7 3.4 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain MRAP PF15183.4 001009101.1_39723001_1 - 0.65 9.9 2.6 1.3 8.9 0.4 2.3 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family 7tm_1 PF00001.19 214298.1_49823001_1 - 1.6e-77 260.3 10.5 2e-77 259.9 10.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 214298.1_49823001_1 - 1.5e-10 40.8 8.4 2e-09 37.1 8.4 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 214298.1_49823001_1 - 6.9e-06 25.4 5.3 6.9e-06 25.4 5.3 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 214298.1_49823001_1 - 4.3e-05 23.3 7.0 0.00018 21.2 3.5 2.2 2 0 0 2 2 2 1 Olfactory receptor WAP PF00095.19 213870.1_49822001_2 - 9.9e-18 64.1 39.5 1.3e-09 38.1 14.8 2.5 2 0 0 2 2 2 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' EB PF01683.16 213870.1_49822001_2 - 3.1 8.0 25.0 3.2 7.9 9.9 2.6 2 0 0 2 2 2 0 EB module RnaseA PF00074.18 001009156.1_39721001_1 - 2.1e-36 125.0 4.2 2.4e-36 124.8 4.2 1.0 1 0 0 1 1 1 1 Pancreatic ribonuclease Tr-sialidase_C PF11052.6 001009156.1_39721001_1 - 0.6 10.2 13.3 1 9.5 13.3 1.3 1 0 0 1 1 1 0 Trans-sialidase of Trypanosoma hydrophobic C-terminal zf-C2H2 PF00096.24 024137.1_45729001_2 - 4.8e-17 61.2 26.5 0.00014 22.0 1.4 5.0 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 024137.1_45729001_2 - 7.9e-11 41.8 8.2 4.7e-07 29.8 0.9 6.2 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_jaz PF12171.6 024137.1_45729001_2 - 2.2e-09 37.3 22.7 0.002 18.2 1.3 4.9 4 0 0 4 4 4 4 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.4 024137.1_45729001_2 - 6.4e-09 35.8 23.7 0.088 13.6 0.4 5.2 4 0 0 4 4 4 4 C2H2-type zinc finger zf-H2C2_5 PF13909.4 024137.1_45729001_2 - 0.00067 19.2 21.6 0.13 11.9 0.6 4.6 4 0 0 4 4 4 3 C2H2-type zinc-finger domain NOA36 PF06524.10 024137.1_45729001_2 - 0.012 14.9 22.8 0.085 12.1 13.6 2.3 2 0 0 2 2 2 0 NOA36 protein zf-met PF12874.5 024137.1_45729001_2 - 0.022 15.0 26.7 0.025 14.8 2.5 4.6 4 0 0 4 4 4 0 Zinc-finger of C2H2 type FYDLN_acid PF09538.8 024137.1_45729001_2 - 0.79 10.3 10.2 21 5.7 8.7 3.2 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) zf-C2H2_2 PF12756.5 024137.1_45729001_2 - 0.8 9.9 17.5 0.19 11.9 3.9 3.7 2 2 1 3 3 3 0 C2H2 type zinc-finger (2 copies) DNA_pol_phi PF04931.11 024137.1_45729001_2 - 2.5 6.0 10.0 4.1 5.3 10.0 1.2 1 0 0 1 1 1 0 DNA polymerase phi 7tm_2 PF00002.22 214036.1_49826001_1 - 1.6e-92 309.1 12.6 1.6e-92 309.1 12.6 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 214036.1_49826001_1 - 2.1e-18 66.2 1.4 6.2e-18 64.7 1.4 1.9 1 0 0 1 1 1 1 Hormone receptor domain 7tm_1 PF00001.19 214036.1_49826001_1 - 0.0001 21.5 0.5 0.00017 20.8 0.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Dicty_CAR PF05462.9 214036.1_49826001_1 - 0.26 10.2 12.0 0.4 9.6 12.0 1.2 1 0 0 1 1 1 0 Slime mold cyclic AMP receptor 7tm_1 PF00001.19 001009046.1_39723001_1 - 1.2e-46 159.0 24.2 2.1e-46 158.2 24.2 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001009046.1_39723001_1 - 7.2e-07 28.7 24.4 9.2e-07 28.4 24.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001009046.1_39723001_1 - 0.72 9.4 21.0 3.5 7.2 21.0 2.3 1 1 0 1 1 1 0 Olfactory receptor GM_CSF PF01109.15 001009805.1_39521001_2 - 1.3e-70 235.1 0.3 1.6e-70 234.8 0.3 1.0 1 0 0 1 1 1 1 Granulocyte-macrophage colony-stimulating factor MHC_I PF00129.16 001009081.1_39724001_1 - 1.6e-94 314.3 2.5 2.3e-94 313.8 2.5 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001009081.1_39724001_1 - 5.4e-17 61.9 0.0 1.1e-16 60.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001009081.1_39724001_1 - 4.1e-14 52.1 12.0 7.5e-14 51.2 12.0 1.5 1 0 0 1 1 1 1 MHC_I C-terminus MHC_I_3 PF16497.3 001009081.1_39724001_1 - 0.002 17.5 0.0 0.003 16.9 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain C2-set_2 PF08205.10 001009081.1_39724001_1 - 0.0021 17.9 1.9 0.0032 17.4 0.1 2.2 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001009081.1_39724001_1 - 0.0022 18.0 1.0 0.006 16.6 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin domain Peptidase_M20 PF01546.26 213896.1_49823001_1 - 1.1e-36 126.3 0.0 1.6e-36 125.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.12 213896.1_49823001_1 - 1.9e-13 50.2 0.0 3.3e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.15 213896.1_49823001_1 - 2.5e-06 27.2 0.0 6.4e-05 22.6 0.0 2.2 2 0 0 2 2 2 1 Peptidase family M28 GRIP PF01465.18 213896.1_49823001_1 - 0.14 11.9 0.1 0.47 10.3 0.1 1.9 1 0 0 1 1 1 0 GRIP domain zf-CCCH PF00642.22 001009765.1_39522001_1 - 1.8e-21 75.4 16.9 1.3e-11 43.9 3.3 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.4 001009765.1_39522001_1 - 2.9e-05 24.2 8.1 0.015 15.6 0.6 2.6 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger Torus PF16131.3 001009765.1_39522001_1 - 0.00096 19.7 10.2 0.14 12.7 1.3 2.2 1 1 1 2 2 2 2 Torus domain zf-CCHH PF10283.7 001009765.1_39522001_1 - 1.3 9.1 8.3 7.7 6.5 0.7 2.7 2 0 0 2 2 2 0 Zinc-finger (CX5CX6HX5H) motif BAMBI PF06211.10 001009761.1_39522001_1 - 3.8e-63 210.3 7.8 6.5e-63 209.6 7.8 1.4 1 0 0 1 1 1 1 BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain DUF1049 PF06305.9 001009761.1_39522001_1 - 0.044 13.5 1.4 0.077 12.7 1.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) JIP_LZII PF16471.3 001009761.1_39522001_1 - 0.061 13.4 0.7 16 5.6 0.0 2.3 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II EphA2_TM PF14575.4 001009761.1_39522001_1 - 0.089 13.5 0.1 0.21 12.3 0.1 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Peptidase_S8 PF00082.20 031137.1_45729001_2 - 7e-111 370.1 3.4 1e-110 369.6 3.4 1.3 1 0 0 1 1 1 1 Subtilase family TPPII PF12580.6 031137.1_45729001_2 - 4e-77 257.9 0.0 6.4e-77 257.2 0.0 1.3 1 0 0 1 1 1 1 Tripeptidyl peptidase II RnaseA PF00074.18 001009131.1_39722001_1 - 2.9e-21 76.1 4.5 3.6e-21 75.8 4.5 1.1 1 0 0 1 1 1 1 Pancreatic ribonuclease RnaseA PF00074.18 001007111.1_49822001_1 - 1.2e-20 74.1 2.8 1.8e-20 73.5 2.8 1.2 1 0 0 1 1 1 1 Pancreatic ribonuclease Cytadhesin_P30 PF07271.9 001007111.1_49822001_1 - 0.16 11.4 0.0 0.22 10.9 0.0 1.1 1 0 0 1 1 1 0 Cytadhesin P30/P32 Lactamase_B_4 PF13691.4 001009034.1_39726001_1 - 1.3e-16 59.9 0.0 3.3e-16 58.6 0.0 1.7 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B_2 PF12706.5 001009034.1_39726001_1 - 3.8e-14 52.5 0.1 3.2e-11 43.0 0.8 3.0 3 1 0 3 3 3 2 Beta-lactamase superfamily domain Lactamase_B PF00753.25 001009034.1_39726001_1 - 0.0011 18.9 0.7 0.0043 17.0 0.3 2.1 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily p450 PF00067.20 001033686.1_45726001_3 - 3.6e-133 444.6 0.0 4.5e-133 444.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 SH3_9 PF14604.4 001008984.1_39724001_1 - 1.8e-10 40.4 0.0 4e-10 39.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001008984.1_39724001_1 - 2.3e-05 23.8 0.0 4.6e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SKI PF01202.20 001008984.1_39724001_1 - 0.081 12.9 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 Shikimate kinase NodZ PF05830.9 001008984.1_39724001_1 - 0.082 11.6 0.3 0.33 9.6 0.0 1.9 2 0 0 2 2 2 0 Nodulation protein Z (NodZ) Wtap PF17098.3 001008984.1_39724001_1 - 0.2 11.5 1.5 1.4 8.8 0.1 2.3 2 0 0 2 2 2 0 WTAP/Mum2p family DUF1043 PF06295.10 001008984.1_39724001_1 - 3.3 7.6 5.2 3.3 7.6 0.4 3.0 3 1 1 4 4 4 0 Protein of unknown function (DUF1043) RGS PF00615.17 214138.1_49824001_2 - 4e-26 91.5 0.8 1.3e-08 35.0 0.0 3.4 3 0 0 3 3 3 3 Regulator of G protein signaling domain Pro-rich PF15240.4 172064.1_45722001_2 - 4.5e-33 114.9 70.3 1.7e-25 90.2 18.1 2.0 1 1 1 2 2 2 2 Proline-rich GRP PF07172.9 172064.1_45722001_2 - 0.012 16.1 0.0 0.024 15.2 0.0 1.5 1 0 0 1 1 1 0 Glycine rich protein family DUF3302 PF11742.6 172064.1_45722001_3 - 0.57 10.2 8.0 0.17 11.9 0.8 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3302) zf-C3HC4_3 PF13920.4 001009346.1_22425001_2 - 6.8e-13 48.1 8.9 6.8e-13 48.1 8.9 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RanBP PF00641.16 001009346.1_22425001_2 - 4e-09 35.5 5.2 4e-09 35.5 5.2 2.7 3 0 0 3 3 3 1 Zn-finger in Ran binding protein and others SWIB PF02201.16 001009346.1_22425001_2 - 4.7e-09 35.9 0.0 9.3e-09 34.9 0.0 1.5 1 0 0 1 1 1 1 SWIB/MDM2 domain zf-RING_2 PF13639.4 001009346.1_22425001_2 - 0.012 15.7 8.3 0.012 15.7 8.3 2.4 2 0 0 2 2 2 0 Ring finger domain Pinin_SDK_N PF04697.11 001009346.1_22425001_2 - 0.036 14.6 0.9 0.036 14.6 0.9 2.1 3 0 0 3 3 3 0 pinin/SDK conserved region DZR PF12773.5 001009346.1_22425001_2 - 0.044 13.7 7.9 0.51 10.3 1.3 3.1 2 0 0 2 2 2 0 Double zinc ribbon zf-FPG_IleRS PF06827.12 001009346.1_22425001_2 - 0.13 12.0 0.1 0.13 12.0 0.1 3.3 3 0 0 3 3 3 0 Zinc finger found in FPG and IleRS Menin PF05053.11 001009346.1_22425001_2 - 0.18 10.0 1.2 0.28 9.4 1.2 1.2 1 0 0 1 1 1 0 Menin zinc_ribbon_2 PF13240.4 001009346.1_22425001_2 - 1.1 9.0 10.5 0.31 10.7 3.4 3.0 2 0 0 2 2 2 0 zinc-ribbon domain zinc-ribbons_6 PF07191.10 001009346.1_22425001_2 - 4.9 7.1 10.6 1.2 9.0 4.1 2.8 2 0 0 2 2 2 0 zinc-ribbons ERM PF00769.17 001009576.1_49825001_1 - 1.4e-75 254.1 51.8 1.4e-75 254.1 51.8 2.5 1 1 1 2 2 2 1 Ezrin/radixin/moesin family FERM_M PF00373.16 001009576.1_49825001_1 - 3.1e-28 98.4 1.0 3.1e-28 98.4 1.0 3.5 2 1 0 2 2 2 1 FERM central domain FERM_C PF09380.8 001009576.1_49825001_1 - 5.6e-28 97.0 0.0 1.9e-27 95.4 0.0 2.0 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.8 001009576.1_49825001_1 - 3.7e-15 55.5 0.9 2.1e-14 53.1 0.1 2.4 2 0 0 2 2 2 1 FERM N-terminal domain Hamartin PF04388.10 001009576.1_49825001_1 - 8 4.8 28.4 13 4.2 28.4 1.2 1 0 0 1 1 1 0 Hamartin protein Sp38 PF07354.10 214106.1_49823001_3 - 8.7e-132 437.9 5.3 1e-131 437.6 5.3 1.0 1 0 0 1 1 1 1 Zona-pellucida-binding protein (Sp38) Ig_3 PF13927.4 214106.1_49823001_3 - 0.00087 19.7 0.0 0.0019 18.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 214106.1_49823001_3 - 0.014 15.3 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain ig PF00047.23 214106.1_49823001_3 - 0.025 14.6 0.0 0.051 13.6 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain DDHD PF02862.15 001136151.1_45727001_1 - 0.058 13.4 7.2 0.091 12.7 7.2 1.2 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.15 001136151.1_45727001_1 - 0.12 11.0 14.6 0.17 10.5 14.6 1.1 1 0 0 1 1 1 0 Presenilin DUF2828 PF11443.6 001136151.1_45727001_1 - 0.18 9.8 4.8 0.26 9.3 4.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) GREB1 PF15782.3 001136151.1_45727001_1 - 0.79 6.6 13.3 1.1 6.2 13.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Pex14_N PF04695.11 001136151.1_45727001_1 - 0.86 10.2 20.5 3 8.4 20.5 1.9 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region HSP70 PF00012.18 001136151.1_45727001_1 - 1.2 7.1 5.6 1.7 6.6 5.6 1.0 1 0 0 1 1 1 0 Hsp70 protein SpoIIP PF07454.9 001136151.1_45727001_1 - 1.5 8.1 11.2 2.3 7.5 11.2 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CPSF100_C PF13299.4 001136151.1_45727001_1 - 1.9 8.5 11.4 3.2 7.8 11.4 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal FAM176 PF14851.4 001136151.1_45727001_1 - 1.9 8.0 5.7 3.5 7.2 5.7 1.3 1 0 0 1 1 1 0 FAM176 family TFIIA PF03153.11 001136151.1_45727001_1 - 3.7 7.3 37.5 0.31 10.9 32.7 1.6 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.7 001136151.1_45727001_1 - 4.4 5.3 27.5 6.4 4.8 27.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 EPL1 PF10513.7 001136151.1_45727001_1 - 4.5 7.5 15.8 7.6 6.8 15.8 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like Band_3_cyto PF07565.11 001136151.1_45727001_1 - 6 6.4 15.0 9.3 5.8 15.0 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SLC12 PF03522.13 001136151.1_45727001_1 - 8.6 5.1 11.4 12 4.6 11.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Neuregulin PF02158.13 001136151.1_45727001_2 - 4e-167 556.6 12.4 4e-167 556.6 12.4 2.2 2 0 0 2 2 2 1 Neuregulin family I-set PF07679.14 001136151.1_45727001_2 - 3.7e-17 62.0 0.0 6.5e-17 61.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001136151.1_45727001_2 - 8.9e-16 58.2 0.0 8.9e-16 58.2 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001136151.1_45727001_2 - 4e-13 49.2 0.0 1e-12 47.9 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001136151.1_45727001_2 - 5.1e-10 39.4 0.0 1.9e-09 37.6 0.0 2.0 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 001136151.1_45727001_2 - 0.013 15.5 0.0 0.69 10.0 0.0 2.9 1 1 0 1 1 1 0 Immunoglobulin V-set domain EGF PF00008.25 001136151.1_45727001_2 - 0.06 13.5 6.9 0.18 12.0 6.9 1.9 1 0 0 1 1 1 0 EGF-like domain EGF_2 PF07974.11 001136151.1_45727001_2 - 0.12 12.7 10.0 0.33 11.2 10.0 1.9 1 0 0 1 1 1 0 EGF-like domain Neur_chan_memb PF02932.14 001136151.1_45727001_2 - 4 7.3 8.0 1.7 8.5 0.5 2.4 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region 7tm_1 PF00001.19 214027.1_49824001_2 - 6.9e-45 153.2 12.0 9.3e-45 152.8 12.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 214027.1_49824001_2 - 5.2e-06 26.3 3.5 5.2e-06 26.3 3.5 2.0 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 214027.1_49824001_2 - 3.1e-05 23.4 9.2 4.9e-05 22.7 9.2 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Gaa1 PF04114.12 214027.1_49824001_2 - 0.0023 16.9 3.7 0.031 13.2 0.1 2.0 1 1 0 2 2 2 2 Gaa1-like, GPI transamidase component RCC1 PF00415.16 001012074.1_45728001_1 - 3e-91 299.7 20.9 4.1e-15 56.0 0.0 7.5 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat HECT PF00632.23 001012074.1_45728001_1 - 2.2e-88 296.5 0.4 4.3e-88 295.6 0.4 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) RCC1_2 PF13540.4 001012074.1_45728001_1 - 1.7e-46 155.0 34.9 5.4e-11 41.9 0.4 7.6 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat DUF2745 PF10922.6 001012074.1_45728001_1 - 0.064 13.4 0.1 0.18 12.0 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2745) DUF563 PF04577.12 001012724.1_39724001_1 - 3.8e-22 79.3 0.1 7.1e-22 78.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF563) 7tm_1 PF00001.19 001009051.1_39723001_1 - 1.5e-41 142.3 28.8 9.3e-41 139.7 28.8 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001009051.1_39723001_1 - 7.3e-05 22.1 26.5 9.2e-05 21.8 26.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Peroxin-13_N PF04088.11 001009051.1_39723001_1 - 0.066 13.3 1.4 0.19 11.9 0.1 2.4 2 1 0 2 2 2 0 Peroxin 13, N-terminal region RA PF00788.21 001024275.1_45725001_3 - 2e-13 50.6 0.0 5.5e-13 49.2 0.0 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Nore1-SARAH PF16517.3 001024275.1_45725001_3 - 5.6e-13 48.5 5.6 5.6e-13 48.5 5.6 2.4 2 0 0 2 2 2 1 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Ldh_1_C PF02866.16 001009329.1_22423001_1 - 5.5e-45 153.2 0.0 1.8e-44 151.5 0.0 1.7 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.21 001009329.1_22423001_1 - 3.9e-38 130.6 0.2 8.1e-38 129.6 0.2 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain DUF4809 PF16067.3 001009329.1_22423001_1 - 0.1 12.6 0.2 0.87 9.6 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4809) Rab5-bind PF09311.9 001009766.1_39526001_1 - 0.0015 17.8 6.1 0.0024 17.2 6.1 1.2 1 0 0 1 1 1 1 Rabaptin-like protein Leu_zip PF15294.4 001009766.1_39526001_1 - 0.036 13.4 6.3 0.056 12.8 6.3 1.2 1 0 0 1 1 1 0 Leucine zipper IncA PF04156.12 001009766.1_39526001_1 - 0.053 13.2 15.5 0.085 12.5 14.8 1.7 1 1 0 1 1 1 0 IncA protein Spc7 PF08317.9 001009766.1_39526001_1 - 0.065 12.0 9.6 0.096 11.4 9.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein CK2S PF15011.4 001009766.1_39526001_1 - 0.066 12.9 5.6 0.13 12.0 5.6 1.4 1 0 0 1 1 1 0 Casein Kinase 2 substrate HAUS-augmin3 PF14932.4 001009766.1_39526001_1 - 0.13 11.6 10.2 0.26 10.6 10.2 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Fez1 PF06818.13 001009766.1_39526001_1 - 0.15 12.4 11.4 0.018 15.3 4.5 2.2 2 0 0 2 2 2 0 Fez1 V_ATPase_I PF01496.17 001009766.1_39526001_1 - 0.16 9.7 1.2 0.23 9.2 1.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family BST2 PF16716.3 001009766.1_39526001_1 - 0.39 11.2 4.5 0.68 10.4 3.8 1.8 1 1 0 1 1 1 0 Bone marrow stromal antigen 2 DUF342 PF03961.11 001009766.1_39526001_1 - 0.45 8.9 4.5 0.68 8.3 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) CENP-H PF05837.10 001009766.1_39526001_1 - 0.58 10.4 8.3 0.32 11.3 5.4 2.0 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF1664 PF07889.10 001009766.1_39526001_1 - 0.71 9.7 4.5 0.72 9.7 1.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) IFT57 PF10498.7 001009766.1_39526001_1 - 0.72 8.6 12.5 0.047 12.5 7.6 1.4 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 DUF3584 PF12128.6 001009766.1_39526001_1 - 0.73 7.1 10.0 1 6.7 10.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ADIP PF11559.6 001009766.1_39526001_1 - 1.2 9.0 10.7 2.2 8.2 9.7 1.8 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding CorA PF01544.16 001009766.1_39526001_1 - 1.3 8.1 6.4 2 7.5 6.4 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Exonuc_VII_L PF02601.13 001009766.1_39526001_1 - 1.6 8.1 5.7 2.4 7.5 5.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit ERM PF00769.17 001009766.1_39526001_1 - 3.8 7.1 18.8 0.27 10.9 13.2 1.8 2 0 0 2 2 2 0 Ezrin/radixin/moesin family CENP-Q PF13094.4 001009766.1_39526001_1 - 5 7.2 12.2 19 5.3 12.1 1.9 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit APG6 PF04111.10 001009766.1_39526001_1 - 6.9 5.8 10.1 13 4.9 10.1 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 Pro-kuma_activ PF09286.9 001013007.1_39724001_1 - 7e-32 110.5 0.0 1.2e-31 109.7 0.0 1.4 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.20 001013007.1_39724001_1 - 0.00033 19.9 0.1 0.00051 19.3 0.1 1.2 1 0 0 1 1 1 1 Subtilase family SPARC_Ca_bdg PF10591.7 001031794.1_49824001_1 - 1.2e-39 134.9 0.2 2.5e-39 133.9 0.2 1.5 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Kazal_1 PF00050.19 001031794.1_49824001_1 - 1e-13 50.9 7.7 3.3e-13 49.3 4.4 2.5 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.13 001031794.1_49824001_1 - 1.4e-10 41.1 2.2 1.4e-10 41.1 2.2 2.3 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain FOLN PF09289.8 001031794.1_49824001_1 - 2.2e-09 37.2 7.8 7.1e-09 35.5 7.8 2.0 1 0 0 1 1 1 1 Follistatin/Osteonectin-like EGF domain EF-hand_1 PF00036.30 001031794.1_49824001_1 - 0.15 11.5 0.0 0.74 9.4 0.1 2.1 2 0 0 2 2 2 0 EF hand hEGF PF12661.5 001031794.1_49824001_1 - 2 9.1 8.2 0.3 11.7 2.5 2.8 2 0 0 2 2 2 0 Human growth factor-like EGF 7tm_4 PF13853.4 001009115.1_39722001_1 - 1.2e-55 189.1 16.1 1.4e-55 188.9 16.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.19 001009115.1_39722001_1 - 1.7e-24 86.4 18.0 7.1e-24 84.3 18.0 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001009115.1_39722001_1 - 4e-05 23.0 15.2 6.3e-05 22.3 15.2 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001009115.1_39722001_1 - 0.0059 15.8 15.3 0.028 13.6 15.3 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx ATP-synt_C PF00137.19 001009195.1_39521001_1 - 9.2e-38 128.3 37.5 1e-22 80.1 14.1 2.1 2 0 0 2 2 2 2 ATP synthase subunit C SCAMP PF04144.11 001009195.1_39521001_1 - 2.2 8.4 7.9 0.13 12.4 2.6 1.7 2 0 0 2 2 2 0 SCAMP family NADH5_C PF06455.9 001009195.1_39521001_1 - 4.1 6.8 9.2 0.1 12.0 2.9 1.5 2 0 0 2 2 2 0 NADH dehydrogenase subunit 5 C-terminus Cu-oxidase_2 PF07731.12 001009733.1_39527001_2 - 2.3e-26 92.0 14.9 1.2e-12 47.6 4.6 6.3 6 0 0 6 6 6 5 Multicopper oxidase Cu-oxidase_3 PF07732.13 001009733.1_39527001_2 - 2.9e-25 88.5 4.2 3.1e-07 30.3 0.0 5.2 4 1 0 4 4 4 3 Multicopper oxidase Cu-oxidase PF00394.20 001009733.1_39527001_2 - 3.2e-13 50.0 1.2 6.5e-10 39.2 0.0 4.5 3 1 0 3 3 3 1 Multicopper oxidase Carb_anhydrase PF00194.19 001009771.1_39523001_2 - 2e-93 312.5 0.0 2.4e-93 312.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Pkinase_Tyr PF07714.15 001034123.1_39725001_1 - 2.4e-95 318.6 0.0 3.2e-95 318.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001034123.1_39725001_1 - 7.8e-46 156.4 0.0 1.1e-45 155.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 001034123.1_39725001_1 - 1.9e-20 72.6 0.0 2.9e-10 40.0 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin I-set domain TPKR_C2 PF16920.3 001034123.1_39725001_1 - 2.4e-19 69.0 7.4 8.3e-19 67.3 7.4 2.0 1 0 0 1 1 1 1 Tyrosine-protein kinase receptor C2 Ig-like domain ig PF00047.23 001034123.1_39725001_1 - 2.2e-18 66.1 0.4 2.5e-15 56.3 0.3 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001034123.1_39725001_1 - 6.6e-18 65.0 1.5 6.3e-10 39.4 0.9 2.7 2 0 0 2 2 2 2 Immunoglobulin domain LRR_8 PF13855.4 001034123.1_39725001_1 - 2.7e-13 49.3 2.3 2.7e-13 49.3 2.3 1.9 2 0 0 2 2 2 1 Leucine rich repeat Ig_2 PF13895.4 001034123.1_39725001_1 - 9.5e-13 48.2 1.0 3.3e-07 30.4 0.3 2.5 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001034123.1_39725001_1 - 7e-09 35.5 0.5 0.00053 19.9 0.1 2.5 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain LRRNT PF01462.16 001034123.1_39725001_1 - 1.1e-06 27.9 2.2 3.7e-06 26.3 2.2 2.0 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_4 PF12799.5 001034123.1_39725001_1 - 2.4e-05 24.5 8.0 0.00085 19.5 0.7 2.7 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001034123.1_39725001_1 - 6.3e-05 22.8 0.9 0.00013 21.7 0.9 1.5 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_6 PF13516.4 001034123.1_39725001_1 - 0.22 11.5 2.0 0.32 11.0 0.3 2.3 2 0 0 2 2 1 0 Leucine Rich repeat LRR_1 PF00560.31 001034123.1_39725001_1 - 1.4 9.5 8.2 6.2 7.6 0.2 5.1 5 0 0 5 5 5 0 Leucine Rich Repeat Hormone_1 PF00103.18 001032993.1_32322001_2 - 4.4e-43 147.4 0.0 5.3e-43 147.1 0.0 1.0 1 0 0 1 1 1 1 Somatotropin hormone family TPR_1 PF00515.26 001009002.1_39727001_1 - 1.4e-27 94.1 17.9 2e-05 24.1 0.0 8.4 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.15 001009002.1_39727001_1 - 3e-17 61.1 18.2 0.06 13.3 0.1 8.6 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_8 PF13181.4 001009002.1_39727001_1 - 3e-16 58.1 14.7 0.0024 17.8 0.4 7.7 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.4 001009002.1_39727001_1 - 3.6e-13 49.8 0.6 0.058 14.0 0.0 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.4 001009002.1_39727001_1 - 3.8e-11 42.4 4.2 0.0038 17.4 0.0 4.9 5 0 0 5 5 3 3 Tetratricopeptide repeat TPR_12 PF13424.4 001009002.1_39727001_1 - 8e-11 41.9 8.0 0.065 13.4 0.1 5.1 3 1 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.4 001009002.1_39727001_1 - 3.7e-08 32.7 8.4 0.28 11.2 0.2 6.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.4 001009002.1_39727001_1 - 8.6e-08 32.5 6.9 0.038 14.4 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.4 001009002.1_39727001_1 - 4.5e-07 30.0 4.3 1.1 10.1 0.0 5.6 4 2 2 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.4 001009002.1_39727001_1 - 4.9e-05 22.8 9.3 0.035 13.7 0.0 5.6 4 3 1 5 5 5 1 TPR repeat TPR_9 PF13371.4 001009002.1_39727001_1 - 0.00044 20.2 4.3 0.011 15.8 0.1 3.8 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.4 001009002.1_39727001_1 - 0.0021 17.7 0.9 20 5.1 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.4 001009002.1_39727001_1 - 0.0071 16.8 9.6 1.8 9.2 0.1 6.8 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_15 PF13429.4 001009002.1_39727001_1 - 0.033 13.3 6.0 0.29 10.2 2.0 3.6 2 1 0 2 2 2 0 Tetratricopeptide repeat SNAP PF14938.4 001009002.1_39727001_1 - 0.64 9.3 11.5 5 6.3 0.7 3.5 2 2 0 3 3 3 0 Soluble NSF attachment protein, SNAP ANAPC3 PF12895.5 001009002.1_39727001_1 - 2.4 8.3 0.0 2.4 8.3 0.0 4.1 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Interferon PF00143.17 001009297.1_22422001_1 - 6.9e-55 185.5 8.2 8e-55 185.2 8.2 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain Cofilin_ADF PF00241.18 001009484.2_39522001_3 - 3.4e-31 107.9 1.9 4.2e-31 107.6 1.9 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein RPA_interact_N PF14766.4 001009484.2_39522001_3 - 0.11 12.0 0.1 0.22 11.1 0.1 1.5 1 0 0 1 1 1 0 Replication protein A interacting N-terminal Abhydrolase_1 PF00561.18 001001641.1_49824001_1 - 3.2e-40 138.2 0.0 4.9e-40 137.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001001641.1_49824001_1 - 1.4e-15 58.4 0.0 2.7e-15 57.5 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.6 001001641.1_49824001_1 - 2.6e-13 49.7 0.0 3.8e-12 45.9 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 HAD_2 PF13419.4 001001641.1_49824001_1 - 1.1e-09 38.5 0.0 3.2e-09 37.0 0.0 1.9 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.24 001001641.1_49824001_1 - 1.5e-09 38.3 0.0 2.8e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Ndr PF03096.12 001001641.1_49824001_1 - 0.0048 15.5 0.0 0.01 14.4 0.0 1.4 1 0 0 1 1 1 1 Ndr family E2_bind PF08825.8 001001641.1_49824001_1 - 0.033 14.2 0.0 0.11 12.5 0.0 1.8 1 0 0 1 1 1 0 E2 binding domain HAD PF12710.5 001001641.1_49824001_1 - 0.1 12.9 0.0 0.33 11.2 0.0 1.8 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF1100 PF06500.9 001001641.1_49824001_1 - 0.11 11.2 0.0 0.49 9.0 0.0 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1100) Ldh_1_N PF00056.21 001032975.1_32324001_2 - 1e-50 171.4 0.7 1.6e-50 170.7 0.7 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 001032975.1_32324001_2 - 4.3e-23 81.9 0.0 8.1e-23 81.0 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.14 001032975.1_32324001_2 - 0.015 14.7 0.6 0.036 13.5 0.0 1.9 2 0 0 2 2 2 0 Family 4 glycosyl hydrolase Pyr_redox_2 PF07992.12 001032975.1_32324001_2 - 0.13 11.4 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase IFN-gamma PF00714.15 001009873.1_22422001_1 - 2.4e-69 231.4 3.8 2.9e-69 231.1 3.8 1.0 1 0 0 1 1 1 1 Interferon gamma C1-set PF07654.13 001009876.1_22421001_1 - 4.7e-24 84.5 0.2 5.8e-24 84.3 0.2 1.1 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001009876.1_22421001_1 - 7.5e-05 23.1 0.2 0.00014 22.2 0.0 1.5 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 001009876.1_22421001_1 - 0.0015 18.7 0.1 0.0021 18.3 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001009876.1_22421001_1 - 0.0023 17.8 0.0 0.003 17.5 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain C2-set_2 PF08205.10 001009876.1_22421001_1 - 0.0047 16.8 0.0 0.0064 16.4 0.0 1.2 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001009876.1_22421001_1 - 0.0061 16.6 0.2 0.011 15.8 0.2 1.4 1 1 0 1 1 1 1 Immunoglobulin domain Ammonium_transp PF00909.19 001035523.1_39724001_3 - 1.3e-78 264.4 18.8 1.8e-78 263.9 18.8 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Agouti PF05039.10 001009190.1_22421001_1 - 1.9e-30 105.3 16.0 2.6e-30 104.8 16.0 1.2 1 0 0 1 1 1 1 Agouti protein Toxin_9 PF02819.13 001009190.1_22421001_1 - 0.021 15.0 13.3 0.037 14.2 13.3 1.4 1 0 0 1 1 1 0 Spider toxin ETRAMP PF09716.8 001009190.1_22421001_1 - 0.023 14.6 1.5 0.047 13.6 1.5 1.5 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) IL8 PF00048.18 001032852.1_29621001_1 - 8.1e-20 70.6 1.8 1e-19 70.3 1.8 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Filament PF00038.19 001009148.2_39724001_2 - 1.8e-113 379.1 51.4 2.2e-113 378.8 51.4 1.1 1 0 0 1 1 1 1 Intermediate filament protein Filament_head PF04732.12 001009148.2_39724001_2 - 1.2e-20 74.0 19.9 1.2e-20 74.0 19.9 2.5 2 1 0 2 2 1 1 Intermediate filament head (DNA binding) region Reo_sigmaC PF04582.10 001009148.2_39724001_2 - 0.0054 16.0 6.8 0.62 9.3 0.3 3.0 1 1 2 3 3 3 2 Reovirus sigma C capsid protein DUF1664 PF07889.10 001009148.2_39724001_2 - 0.0061 16.4 24.4 0.013 15.4 0.8 3.9 3 1 2 5 5 5 2 Protein of unknown function (DUF1664) MdcG PF10620.7 001009148.2_39724001_2 - 0.05 13.2 2.2 0.068 12.8 0.6 2.0 2 0 0 2 2 2 0 Phosphoribosyl-dephospho-CoA transferase MdcG Golgin_A5 PF09787.7 001009148.2_39724001_2 - 0.075 12.4 44.2 0.28 10.5 25.6 2.3 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF573 PF04504.12 001009148.2_39724001_2 - 0.13 12.8 8.8 0.63 10.6 0.7 3.4 2 2 1 3 3 3 0 Protein of unknown function, DUF573 DUF3584 PF12128.6 001009148.2_39724001_2 - 0.19 9.0 42.8 0.48 7.7 42.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Jnk-SapK_ap_N PF09744.7 001009148.2_39724001_2 - 0.33 11.0 47.3 0.25 11.4 19.8 3.5 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 TPR_MLP1_2 PF07926.10 001009148.2_39724001_2 - 0.37 10.7 54.1 1.2 9.0 20.1 4.1 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Laminin_II PF06009.10 001009148.2_39724001_2 - 0.73 9.7 27.8 0.98 9.3 10.0 3.6 1 1 1 3 3 3 0 Laminin Domain II DUF4515 PF14988.4 001009148.2_39724001_2 - 0.73 9.5 45.5 0.49 10.1 31.5 3.4 1 1 2 3 3 3 0 Domain of unknown function (DUF4515) CENP-F_leu_zip PF10473.7 001009148.2_39724001_2 - 0.77 9.7 44.1 0.062 13.2 7.1 3.7 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Trimer_CC PF08954.9 001009148.2_39724001_2 - 1.6 8.2 10.8 23 4.5 3.0 4.0 3 0 0 3 3 3 0 Trimerisation motif Baculo_PEP_C PF04513.10 001009148.2_39724001_2 - 3.7 7.5 20.7 3.3 7.6 1.2 4.5 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus GAS PF13851.4 001009148.2_39724001_2 - 3.8 6.7 48.4 0.26 10.5 12.1 3.6 1 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding IncA PF04156.12 001009148.2_39724001_2 - 3.9 7.1 53.7 6.4 6.4 1.0 4.0 1 1 2 3 3 3 0 IncA protein DUF5082 PF16888.3 001009148.2_39724001_2 - 4.6 7.5 27.0 0.87 9.8 11.7 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) Fer2 PF00111.25 001009148.2_39724001_3 - 1.2 9.0 6.7 0.48 10.3 2.5 2.4 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain 7tm_1 PF00001.19 001009752.1_39525001_1 - 3.6e-44 150.9 12.9 4.5e-44 150.6 12.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001009752.1_39525001_1 - 3.8e-06 26.7 2.5 3.8e-06 26.7 2.5 2.1 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001009752.1_39525001_1 - 9.6e-05 21.8 9.0 0.00015 21.1 9.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Gaa1 PF04114.12 001009752.1_39525001_1 - 0.017 14.1 4.3 0.039 12.9 0.6 2.0 2 0 0 2 2 2 0 Gaa1-like, GPI transamidase component E1_DerP2_DerF2 PF02221.13 001009075.1_39722001_1 - 9.6e-30 103.6 2.8 1.2e-29 103.3 2.8 1.1 1 0 0 1 1 1 1 ML domain Med26 PF08711.9 001045500.1_39726001_1 - 1.8e-08 34.1 0.7 3.3e-08 33.3 0.7 1.4 1 0 0 1 1 1 1 TFIIS helical bundle-like domain zf-CCCH PF00642.22 001045500.1_39726001_1 - 4.7e-05 23.1 3.7 8.4e-05 22.2 3.7 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Apo-CIII PF05778.10 001002801.1_49821001_1 - 2.2e-39 132.7 3.8 2.7e-39 132.5 3.8 1.1 1 0 0 1 1 1 1 Apolipoprotein CIII (Apo-CIII) ApoC-I PF04691.10 001002801.1_49821001_1 - 0.00012 21.8 0.2 0.00015 21.5 0.2 1.2 1 0 0 1 1 1 1 Apolipoprotein C-I (ApoC-1) Alanine_zipper PF11839.6 001002801.1_49821001_1 - 0.0054 16.8 1.0 0.0069 16.5 1.0 1.1 1 0 0 1 1 1 1 Alanine-zipper, major outer membrane lipoprotein DUF1394 PF07159.10 001002801.1_49821001_1 - 0.058 12.5 0.1 0.066 12.3 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1394) 7tm_1 PF00001.19 001009324.1_22422001_1 - 6.6e-33 113.9 20.7 3.6e-31 108.3 20.7 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001009324.1_22422001_1 - 1.1e-12 48.2 15.9 3.3e-12 46.6 9.2 2.8 3 1 0 3 3 3 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001009324.1_22422001_1 - 9.9e-09 34.8 15.1 1.3e-07 31.2 15.1 2.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001009324.1_22422001_1 - 0.17 11.0 16.6 0.0066 15.7 9.0 2.3 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx Pox_A14 PF05767.10 001009324.1_22422001_1 - 0.45 10.6 5.8 0.15 12.1 0.7 2.5 1 1 1 2 2 2 0 Poxvirus virion envelope protein A14 UPF0113 PF03657.11 001048071.1_49825001_2 - 7.8e-06 25.9 0.0 1.2e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0113) PUA PF01472.18 001048071.1_49825001_2 - 0.1 12.5 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 PUA domain Bcl-2 PF00452.17 001009374.1_22426001_3 - 1.1e-25 90.0 0.1 2.3e-25 88.9 0.1 1.6 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family Ig_2 PF13895.4 001009077.1_39722001_1 - 7.3e-26 90.2 1.3 2.5e-12 46.8 0.2 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001009077.1_39722001_1 - 4.9e-18 65.4 1.1 6.8e-09 36.1 0.2 2.9 3 0 0 3 3 2 2 Immunoglobulin domain ig PF00047.23 001009077.1_39722001_1 - 7.8e-12 45.1 3.1 7.3e-05 22.7 0.0 3.0 2 1 0 2 2 2 2 Immunoglobulin domain Ig_4 PF16680.3 001009077.1_39722001_1 - 2e-08 34.3 0.1 0.00015 22.0 0.0 2.6 3 0 0 3 3 3 2 T-cell surface glycoprotein CD3 delta chain I-set PF07679.14 001009077.1_39722001_1 - 3e-07 30.3 0.5 0.034 14.1 0.2 3.4 2 2 0 2 2 2 2 Immunoglobulin I-set domain Ig_5 PF16681.3 001009077.1_39722001_1 - 3.4e-07 30.5 0.0 0.00028 21.1 0.0 2.8 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set PF07686.15 001009077.1_39722001_1 - 4.3e-07 29.9 4.4 1.9 8.6 0.0 4.3 2 2 2 4 4 4 3 Immunoglobulin V-set domain C2-set_2 PF08205.10 001009077.1_39722001_1 - 0.00018 21.4 0.2 0.41 10.6 0.0 2.3 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain DUF3827 PF12877.5 001009077.1_39722001_1 - 0.024 12.9 0.9 0.034 12.4 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) RCR PF12273.6 001009077.1_39722001_1 - 0.027 15.0 0.1 5.2 7.6 0.0 2.7 3 0 0 3 3 3 0 Chitin synthesis regulation, resistance to Congo red ECSCR PF15820.3 001009077.1_39722001_1 - 0.029 14.1 1.1 0.081 12.6 0.7 1.8 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator V-set_CD47 PF08204.9 001009077.1_39722001_1 - 0.092 12.6 0.0 0.29 11.0 0.0 1.9 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain BAR_3 PF16746.3 001009021.1_39725001_1 - 1.2e-77 260.7 20.0 1.8e-77 260.1 20.0 1.3 1 0 0 1 1 1 1 BAR domain of APPL family RhoGAP PF00620.25 001009021.1_39725001_1 - 5.4e-42 143.0 0.2 1.8e-41 141.4 0.0 1.9 2 0 0 2 2 2 1 RhoGAP domain PH PF00169.27 001009021.1_39725001_1 - 2.9e-07 30.8 0.8 5.6e-07 29.9 0.1 1.9 2 0 0 2 2 2 1 PH domain Arfaptin PF06456.11 001009021.1_39725001_1 - 0.028 13.9 5.7 0.082 12.3 5.7 1.8 1 0 0 1 1 1 0 Arfaptin-like domain DUF1073 PF06381.9 001009021.1_39725001_1 - 0.078 11.6 1.0 0.11 11.1 0.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1073) Patched PF02460.16 001009021.1_39725001_1 - 1.7 6.4 5.9 1.4 6.8 3.0 1.9 1 1 1 2 2 2 0 Patched family IFN-gamma PF00714.15 001009803.1_39522001_2 - 2.9e-69 231.1 2.5 3.8e-69 230.7 2.5 1.1 1 0 0 1 1 1 1 Interferon gamma API5 PF05918.9 001009803.1_39522001_2 - 0.00019 20.3 2.2 0.00019 20.3 0.7 1.6 1 1 1 2 2 2 1 Apoptosis inhibitory protein 5 (API5) Peptidase_C1 PF00112.21 213892.1_49823001_3 - 1.2e-85 286.9 4.3 1.7e-85 286.4 4.3 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 213892.1_49823001_3 - 3.9e-11 43.1 1.3 6.7e-11 42.3 1.3 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 213892.1_49823001_3 - 0.00022 20.0 3.2 0.077 11.6 1.0 2.2 2 0 0 2 2 2 2 Peptidase C1-like family DEAD PF00270.27 001008986.1_39725001_1 - 5.3e-51 172.7 0.0 2e-50 170.9 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001008986.1_39725001_1 - 2.2e-30 105.1 0.0 4.5e-30 104.1 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 001008986.1_39725001_1 - 0.0011 18.8 0.0 0.002 18.0 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.10 001008986.1_39725001_1 - 0.11 11.1 0.0 0.23 10.1 0.0 1.4 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 RIIa PF02197.15 001032992.1_32323001_1 - 5.3e-15 54.7 0.2 8.5e-15 54.0 0.2 1.3 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit IQ PF00612.25 001032992.1_32323001_1 - 7.7e-07 28.2 0.0 1.3e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 IQ calmodulin-binding motif C1-set PF07654.13 001032984.1_32323001_1 - 5.1e-20 71.6 0.1 8.5e-20 70.9 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001032984.1_32323001_1 - 0.0079 16.7 0.2 0.28 11.7 0.0 2.3 1 1 1 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001032984.1_32323001_1 - 0.011 15.6 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Endothelin PF00322.15 001009387.1_22423001_2 - 3.4e-23 80.8 15.2 3.1e-20 71.3 6.4 2.5 2 0 0 2 2 2 2 Endothelin family Ank_4 PF13637.4 001034076.1_32322001_3 - 1.1e-11 44.9 0.0 0.0012 19.3 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.4 001034076.1_32322001_3 - 4e-09 36.5 0.4 0.00012 22.2 0.1 2.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 001034076.1_32322001_3 - 6.5e-08 32.9 0.0 2.3e-05 24.8 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.28 001034076.1_32322001_3 - 0.00032 20.9 0.0 0.9 10.0 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.4 001034076.1_32322001_3 - 0.0098 16.2 0.0 1.2 9.8 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat IL7 PF01415.14 001009777.1_39522001_1 - 5e-51 172.1 5.0 6.5e-51 171.7 5.0 1.1 1 0 0 1 1 1 1 Interleukin 7/9 family DUF1980 PF09323.8 001009777.1_39522001_1 - 0.1 12.4 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) GST_N_3 PF13417.4 214050.2_49822001_1 - 4e-20 71.8 0.0 1.8e-19 69.7 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 214050.2_49822001_1 - 4.1e-16 58.9 0.0 7.2e-16 58.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.18 214050.2_49822001_1 - 5.2e-12 45.8 0.0 8.9e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.4 214050.2_49822001_1 - 4.8e-09 36.2 0.0 8.2e-09 35.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 214050.2_49822001_1 - 8.8e-09 35.3 0.0 1.3e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 214050.2_49822001_1 - 4.7e-07 29.5 0.0 7.1e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.22 214050.2_49822001_1 - 0.021 14.9 0.0 0.041 14.0 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin GST_C_5 PF16865.3 214050.2_49822001_1 - 0.069 13.6 0.0 0.11 12.9 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Asp PF00026.21 001037721.1_49825001_1 - 6.7e-119 396.8 0.0 8.3e-119 396.5 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001037721.1_49825001_1 - 1.9e-11 44.4 0.4 3.7e-09 37.0 0.4 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001037721.1_49825001_1 - 2.6e-09 36.6 0.0 6.5e-09 35.4 0.0 1.7 1 0 0 1 1 1 1 A1 Propeptide CRF-BP PF05428.9 001009339.1_39523001_2 - 3e-173 574.6 0.0 3.4e-173 574.4 0.0 1.0 1 0 0 1 1 1 1 Corticotropin-releasing factor binding protein (CRF-BP) SAND PF01342.19 001008974.1_39725001_3 - 5.9e-27 93.1 0.0 1.4e-26 91.9 0.0 1.6 1 0 0 1 1 1 1 SAND domain zf-MYND PF01753.16 001008974.1_39725001_3 - 1.7e-09 37.5 14.9 1.7e-09 37.5 14.9 1.8 2 0 0 2 2 2 1 MYND finger Sushi PF00084.18 001009295.1_39526001_1 - 1.2e-65 217.8 84.6 2.9e-09 37.3 3.1 8.6 8 0 0 8 8 8 8 Sushi repeat (SCR repeat) Lectin_C PF00059.19 001009295.1_39526001_1 - 5.3e-22 78.5 5.5 1.8e-21 76.8 5.5 2.0 1 0 0 1 1 1 1 Lectin C-type domain EGF_2 PF07974.11 001009295.1_39526001_1 - 3.1e-05 24.1 9.4 0.00056 20.1 9.4 3.5 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.25 001009295.1_39526001_1 - 0.00023 21.3 8.7 0.00023 21.3 8.7 5.8 8 0 0 8 8 8 1 EGF-like domain EGF_3 PF12947.5 001009295.1_39526001_1 - 0.0058 16.7 4.7 0.0058 16.7 4.7 5.3 6 0 0 6 6 6 1 EGF domain Plasmod_Pvs28 PF06247.9 001009295.1_39526001_1 - 0.054 13.7 9.0 0.29 11.3 6.6 3.5 2 2 0 2 2 2 0 Pvs28 EGF domain DUF4306 PF14154.4 001009295.1_39526001_1 - 0.3 11.2 1.1 0.52 10.4 1.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4306) hEGF PF12661.5 001009295.1_39526001_1 - 1.8 9.2 14.1 0.38 11.4 4.9 5.1 3 0 0 3 3 3 0 Human growth factor-like EGF P53 PF00870.16 001009403.1_39525001_1 - 7.8e-111 368.2 0.2 1.2e-110 367.5 0.2 1.3 1 0 0 1 1 1 1 P53 DNA-binding domain P53_tetramer PF07710.9 001009403.1_39525001_1 - 1.2e-17 62.8 0.9 2.3e-17 61.9 0.9 1.5 1 0 0 1 1 1 1 P53 tetramerisation motif P53_TAD PF08563.9 001009403.1_39525001_1 - 2.1e-13 49.2 3.3 4.6e-13 48.1 3.3 1.6 1 0 0 1 1 1 1 P53 transactivation motif Annexin PF00191.18 001009099.1_39724001_2 - 9.3e-95 310.6 9.1 2.4e-24 85.0 0.3 4.1 4 0 0 4 4 4 4 Annexin RAMP PF04901.11 214089.1_49822001_1 - 2.6e-43 146.3 1.0 3.8e-43 145.8 1.0 1.2 1 0 0 1 1 1 1 Receptor activity modifying family Tr-sialidase_C PF11052.6 214089.1_49822001_1 - 0.1 12.7 5.8 0.21 11.7 5.8 1.4 1 0 0 1 1 1 0 Trans-sialidase of Trypanosoma hydrophobic C-terminal Calcipressin PF04847.10 001009274.1_39525001_2 - 3.2e-62 209.4 0.8 4.2e-62 209.1 0.8 1.1 1 0 0 1 1 1 1 Calcipressin Ig_4 PF16680.3 001009382.1_39523001_1 - 3.6e-26 91.2 0.9 5.9e-26 90.5 0.9 1.4 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 delta chain ITAM PF02189.13 001009382.1_39523001_1 - 1.9e-07 31.0 2.3 3.7e-07 30.1 2.3 1.5 1 0 0 1 1 1 1 Immunoreceptor tyrosine-based activation motif Ig_5 PF16681.3 001009382.1_39523001_1 - 2.6e-06 27.6 0.5 4.4e-06 26.9 0.5 1.4 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain CH_2 PF06294.9 001008990.1_39723001_2 - 1.3e-34 118.0 0.0 2.3e-34 117.3 0.0 1.4 1 0 0 1 1 1 1 CH-like domain in sperm protein CAMSAP_CH PF11971.6 001008990.1_39723001_2 - 3.4e-09 36.3 0.0 7.9e-09 35.1 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain LRR_8 PF13855.4 001009082.1_39724001_3 - 2.4e-39 132.8 16.7 4.8e-15 54.9 1.8 4.4 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 001009082.1_39724001_3 - 3e-19 68.6 22.4 0.00042 20.5 2.5 6.5 1 1 5 8 8 8 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001009082.1_39724001_3 - 5.8e-10 38.8 4.0 4.4e-05 22.9 1.3 3.0 1 1 2 3 3 3 3 Leucine-rich repeat LRRNT PF01462.16 001009082.1_39724001_3 - 7.9e-10 38.0 5.6 7.9e-10 38.0 5.6 2.7 4 0 0 4 4 4 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.31 001009082.1_39724001_3 - 0.00011 22.0 6.8 35 5.3 0.0 6.8 6 2 1 7 7 7 0 Leucine Rich Repeat LRR_6 PF13516.4 001009082.1_39724001_3 - 0.16 12.0 16.9 3.8 7.7 0.0 6.5 6 0 0 6 6 6 0 Leucine Rich repeat adh_short PF00106.23 001009395.2_39523001_2 - 2.8e-48 163.9 1.6 3.6e-48 163.5 1.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001009395.2_39523001_2 - 1.2e-24 87.0 1.2 1.5e-24 86.7 1.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001009395.2_39523001_2 - 1.4e-07 31.5 2.1 4.1e-07 29.9 2.1 1.6 1 1 0 1 1 1 1 KR domain DUF1776 PF08643.8 001009395.2_39523001_2 - 4.1e-05 23.0 0.1 0.00047 19.5 0.0 2.0 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) THF_DHG_CYH_C PF02882.17 001009395.2_39523001_2 - 0.0015 17.7 0.0 0.0026 17.0 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Pyr_redox_3 PF13738.4 001009395.2_39523001_2 - 0.033 13.3 0.0 0.044 12.9 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.17 001009395.2_39523001_2 - 0.039 13.2 0.0 0.061 12.5 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.12 001009395.2_39523001_2 - 0.048 12.8 0.0 0.077 12.1 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.18 001009395.2_39523001_2 - 0.056 13.4 0.1 0.09 12.7 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.13 001009395.2_39523001_2 - 0.062 13.3 0.1 0.1 12.6 0.1 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase FMO-like PF00743.17 001009395.2_39523001_2 - 0.083 11.2 0.0 0.13 10.6 0.0 1.2 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like SIS PF01380.20 001009395.2_39523001_2 - 0.21 11.3 1.2 2.3 7.9 0.0 2.5 3 0 0 3 3 3 0 SIS domain ANP PF00212.16 001008482.1_49821001_1 - 4.1e-15 55.5 7.8 7.7e-15 54.6 7.8 1.5 1 0 0 1 1 1 1 Atrial natriuretic peptide Ank_2 PF12796.5 214005.1_49823001_3 - 4.1e-29 100.9 4.5 1.2e-15 57.7 0.2 2.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 214005.1_49823001_3 - 6.9e-20 70.7 4.7 2.4e-08 34.0 0.3 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) SH3_1 PF00018.26 214005.1_49823001_3 - 2.1e-15 55.9 0.0 3.5e-15 55.2 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 214005.1_49823001_3 - 1.5e-14 53.5 0.0 2.4e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Ank_4 PF13637.4 214005.1_49823001_3 - 2.2e-14 53.5 0.2 1.6e-06 28.4 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) SH3_2 PF07653.15 214005.1_49823001_3 - 8.5e-14 50.9 0.0 1.5e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Ank PF00023.28 214005.1_49823001_3 - 2.9e-12 46.3 0.3 1.9e-05 24.7 0.2 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.4 214005.1_49823001_3 - 3.1e-09 36.2 0.1 0.0083 16.4 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat IL6 PF00489.15 001009211.1_22422001_1 - 4.2e-79 264.3 0.5 4.8e-79 264.1 0.5 1.0 1 0 0 1 1 1 1 Interleukin-6/G-CSF/MGF family GCSF PF16647.3 001009211.1_22422001_1 - 0.0025 17.5 0.0 0.004 16.9 0.0 1.3 1 0 0 1 1 1 1 Granulocyte colony-stimulating factor DUF4924 PF16271.3 001009211.1_22422001_1 - 0.019 14.8 0.3 0.025 14.5 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4924) IL23 PF16649.3 001009211.1_22422001_1 - 0.036 14.0 0.1 0.05 13.5 0.1 1.3 1 0 0 1 1 1 0 Interleukin 23 subunit alpha ICAM_N PF03921.12 001009167.1_39724001_1 - 3.4e-39 132.3 0.2 5.7e-38 128.4 0.1 2.8 4 0 0 4 4 4 1 Intercellular adhesion molecule (ICAM), N-terminal domain Ig_2 PF13895.4 001009167.1_39724001_1 - 7.6e-14 51.7 0.7 0.0022 18.1 0.2 4.5 4 0 0 4 4 4 3 Immunoglobulin domain Ig_3 PF13927.4 001009167.1_39724001_1 - 2.2e-09 37.7 5.3 0.0087 16.5 0.3 4.5 4 1 0 4 4 4 3 Immunoglobulin domain C2-set_2 PF08205.10 001009167.1_39724001_1 - 2.8e-07 30.4 2.6 0.092 12.7 0.1 5.1 4 1 0 4 4 4 1 CD80-like C2-set immunoglobulin domain I-set PF07679.14 001009167.1_39724001_1 - 0.00023 21.0 0.1 7.8 6.5 0.0 4.5 4 0 0 4 4 4 2 Immunoglobulin I-set domain V-set PF07686.15 001009167.1_39724001_1 - 0.042 13.9 1.6 24 5.0 0.1 4.1 3 1 1 4 4 4 0 Immunoglobulin V-set domain Ig_4 PF16680.3 001009167.1_39724001_1 - 0.064 13.5 0.1 22 5.4 0.2 2.9 2 1 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain ig PF00047.23 001009167.1_39724001_1 - 0.1 12.7 7.9 7.3 6.7 0.1 4.8 6 0 0 6 6 6 0 Immunoglobulin domain TF_Zn_Ribbon PF08271.10 025686.2_32923001_2 - 2.2e-07 30.1 4.8 5.2e-07 28.9 4.8 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding TFIIB PF00382.17 025686.2_32923001_2 - 0.00044 20.1 0.0 0.19 11.7 0.0 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat Lar_restr_allev PF14354.4 025686.2_32923001_2 - 0.0014 18.8 1.2 0.0034 17.6 1.2 1.6 1 0 0 1 1 1 1 Restriction alleviation protein Lar A2L_zn_ribbon PF08792.8 025686.2_32923001_2 - 0.022 14.3 3.0 5.1 6.8 1.3 3.3 3 0 0 3 3 3 0 A2L zinc ribbon domain Zn_Tnp_IS1595 PF12760.5 025686.2_32923001_2 - 0.037 13.9 1.3 0.1 12.4 1.3 1.8 1 0 0 1 1 1 0 Transposase zinc-ribbon domain PhnA_Zn_Ribbon PF08274.10 025686.2_32923001_2 - 2.3 8.1 6.0 7.2 6.5 6.0 1.9 1 1 0 1 1 1 0 PhnA Zinc-Ribbon Peptidase_M1 PF01433.18 214017.1_49828001_3 - 6.7e-145 483.1 1.6 9.6e-145 482.6 1.6 1.2 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.6 214017.1_49828001_3 - 1.9e-77 260.8 4.8 3.6e-77 259.9 4.8 1.5 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Cyclophil_like PF04126.11 214017.1_49828001_3 - 0.11 12.2 0.0 0.32 10.7 0.0 1.7 1 0 0 1 1 1 0 Cyclophilin-like DUF1570 PF07607.9 214017.1_49828001_3 - 0.23 11.6 3.6 0.3 11.3 1.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1570) Sod_Cu PF00080.18 001009025.1_39721001_1 - 3.7e-49 166.4 3.4 4.3e-49 166.2 3.4 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) NGF PF00243.16 001012441.1_39722001_1 - 2.4e-48 162.9 2.3 3.2e-48 162.5 2.3 1.2 1 0 0 1 1 1 1 Nerve growth factor family Spaetzle PF16077.3 001012441.1_39722001_1 - 0.0003 21.1 0.6 0.00047 20.4 0.6 1.3 1 0 0 1 1 1 1 Spaetzle Fibrinogen_C PF00147.16 214160.2_49823001_1 - 1.4e-72 243.9 5.9 1.7e-72 243.6 5.9 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Collagen PF01391.16 214160.2_49823001_1 - 2.1e-10 40.1 27.4 5.5e-10 38.7 27.4 1.7 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) DAG_kinase_N PF14513.4 214160.2_49823001_1 - 0.086 12.9 0.0 0.23 11.5 0.0 1.6 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus STAR_dimer PF16544.3 001009232.1_22423001_1 - 1.8e-27 94.5 0.1 3.1e-27 93.8 0.1 1.4 1 0 0 1 1 1 1 Homodimerisation region of STAR domain protein Quaking_NLS PF16551.3 001009232.1_22423001_1 - 1e-20 72.9 5.1 1.7e-20 72.2 5.1 1.4 1 0 0 1 1 1 1 Putative nuclear localisation signal of quaking KH_1 PF00013.27 001009232.1_22423001_1 - 3.7e-06 26.5 0.0 7.3e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 KH domain Pkinase_Tyr PF07714.15 001009837.3_22429001_1 - 7e-103 343.3 0.0 9.9e-103 342.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001009837.3_22429001_1 - 5.6e-43 147.1 0.0 2.2e-30 105.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.4 001009837.3_22429001_1 - 8.2e-23 80.7 7.1 4.2e-07 30.4 0.1 4.6 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.14 001009837.3_22429001_1 - 2.2e-15 56.4 4.2 3.3e-06 26.9 0.1 5.0 4 2 0 4 4 4 3 Immunoglobulin I-set domain ig PF00047.23 001009837.3_22429001_1 - 3.1e-12 46.4 11.8 1.1e-10 41.4 0.3 4.4 4 1 0 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.4 001009837.3_22429001_1 - 1.8e-11 44.0 11.4 0.0031 17.7 0.1 6.0 6 1 0 6 6 5 4 Immunoglobulin domain C1-set PF07654.13 001009837.3_22429001_1 - 0.00042 20.6 5.6 0.0019 18.5 0.2 3.4 3 0 0 3 3 3 1 Immunoglobulin C1-set domain V-set PF07686.15 001009837.3_22429001_1 - 0.00051 20.0 1.3 1.2 9.2 0.0 4.3 3 1 0 3 3 3 1 Immunoglobulin V-set domain Ig_4 PF16680.3 001009837.3_22429001_1 - 0.037 14.2 0.1 8.6 6.7 0.0 3.2 3 0 0 3 3 2 0 T-cell surface glycoprotein CD3 delta chain APH PF01636.21 001009837.3_22429001_1 - 0.13 12.0 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family C2-set_2 PF08205.10 001009837.3_22429001_1 - 0.47 10.4 3.8 0.41 10.6 0.1 2.9 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain WD40 PF00400.30 001014179.1_45724001_1 - 1.7e-42 142.4 24.6 8.7e-07 29.4 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat U-box PF04564.13 001014179.1_45724001_1 - 3.3e-27 94.3 0.2 7.8e-27 93.1 0.2 1.7 1 0 0 1 1 1 1 U-box domain SAM_2 PF07647.15 001014179.1_45724001_1 - 3.4e-16 59.0 0.2 6.6e-16 58.0 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) ANAPC4_WD40 PF12894.5 001014179.1_45724001_1 - 1e-14 54.4 0.0 0.0021 18.2 0.0 4.9 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain SAM_1 PF00536.28 001014179.1_45724001_1 - 7e-14 51.9 0.2 1.2e-13 51.1 0.2 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ge1_WD40 PF16529.3 001014179.1_45724001_1 - 2.1e-11 43.2 6.7 0.0002 20.3 0.0 5.7 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.6 001014179.1_45724001_1 - 5.7e-08 31.4 0.0 0.0038 15.5 0.0 2.5 2 1 1 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz SAM_PNT PF02198.14 001014179.1_45724001_1 - 0.00019 21.2 0.0 0.00046 20.0 0.0 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain zf-NOSIP PF15906.3 001014179.1_45724001_1 - 0.00032 20.6 1.9 0.00085 19.3 0.0 2.6 3 0 0 3 3 3 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.6 001014179.1_45724001_1 - 0.0059 16.3 0.0 0.017 14.8 0.0 1.8 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit eIF2A PF08662.9 001014179.1_45724001_1 - 0.025 14.3 0.0 2 8.1 0.0 2.6 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Ank_2 PF12796.5 001009035.1_39724001_3 - 5.2e-32 110.1 3.1 7.9e-16 58.3 0.3 3.5 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001009035.1_39724001_3 - 2.1e-23 81.9 0.9 1e-09 38.4 0.0 4.8 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.28 001009035.1_39724001_3 - 4.4e-23 80.5 0.4 6.2e-06 26.3 0.0 5.6 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.4 001009035.1_39724001_3 - 2.4e-20 72.5 0.2 1.3e-11 44.7 0.0 3.6 1 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 001009035.1_39724001_3 - 6.4e-20 69.0 0.2 0.0002 21.4 0.0 5.8 6 0 0 6 6 6 3 Ankyrin repeat SAM_2 PF07647.15 001009035.1_39724001_3 - 6.8e-08 32.4 0.2 1.8e-07 31.0 0.2 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 001009035.1_39724001_3 - 3.1e-06 27.4 0.3 7.8e-06 26.1 0.3 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF1359 PF07097.9 001009035.1_39724001_3 - 0.016 15.3 2.9 3.7 7.7 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1359) Spectrin PF00435.19 001009035.1_39724001_3 - 0.073 13.4 1.8 0.14 12.6 0.2 2.2 2 0 0 2 2 2 0 Spectrin repeat SNAPc19 PF15497.4 001009035.1_39724001_3 - 0.4 11.0 4.9 0.19 12.1 1.4 2.2 2 0 0 2 2 2 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 BLOC1_2 PF10046.7 001009035.1_39724001_3 - 0.64 10.2 3.5 0.28 11.4 0.8 1.8 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Peptidase_M41 PF01434.16 053682.2_45727001_2 - 1e-73 247.4 1.8 1.7e-73 246.6 1.8 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.27 053682.2_45727001_2 - 1.6e-41 141.7 0.0 3.9e-41 140.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.4 053682.2_45727001_2 - 8.8e-05 22.8 0.0 0.0027 18.0 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.11 053682.2_45727001_2 - 0.00032 19.6 0.0 0.00063 18.7 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus RuvB_N PF05496.10 053682.2_45727001_2 - 0.00064 18.9 0.0 0.0012 18.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.12 053682.2_45727001_2 - 0.00077 19.3 0.0 0.0025 17.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.4 053682.2_45727001_2 - 0.001 19.2 0.0 0.027 14.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.15 053682.2_45727001_2 - 0.0085 15.7 0.2 0.027 14.1 0.2 1.8 1 1 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.19 053682.2_45727001_2 - 0.023 14.0 0.3 0.052 12.8 0.3 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF815 PF05673.11 053682.2_45727001_2 - 0.023 13.7 0.0 0.053 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_33 PF13671.4 053682.2_45727001_2 - 0.028 14.5 0.0 0.058 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.12 053682.2_45727001_2 - 0.028 14.4 0.0 0.065 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_18 PF13238.4 053682.2_45727001_2 - 0.071 13.5 0.0 0.22 11.9 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_17 PF13207.4 053682.2_45727001_2 - 0.091 13.1 0.0 0.72 10.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain FumaraseC_C PF10415.7 053682.2_45727001_2 - 0.31 11.4 5.8 0.8 10.1 1.5 3.3 5 0 0 5 5 3 0 Fumarase C C-terminus 7tm_1 PF00001.19 001009442.1_39523001_2 - 6.6e-32 110.7 23.5 6.6e-30 104.1 23.5 2.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001009442.1_39523001_2 - 2.6e-13 49.8 12.6 3.3e-11 42.9 12.6 2.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001009442.1_39523001_2 - 2.5e-07 30.6 9.8 2.5e-07 30.6 9.8 2.3 1 1 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001009442.1_39523001_2 - 2.1e-05 23.8 6.4 2.1e-05 23.8 6.4 2.3 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Ribosomal_S4e PF00900.18 001009024.2_39722001_2 - 1.9e-39 133.3 1.0 8.9e-39 131.1 0.8 2.0 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.3 001009024.2_39722001_2 - 1.2e-29 101.6 0.2 2.2e-29 100.7 0.2 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.10 001009024.2_39722001_2 - 4.1e-22 77.9 6.2 9.2e-22 76.7 6.2 1.6 1 0 0 1 1 1 1 RS4NT (NUC023) domain KOW PF00467.27 001009024.2_39722001_2 - 4.6e-06 26.3 1.5 1.9e-05 24.3 1.5 2.2 1 0 0 1 1 1 1 KOW motif S4 PF01479.23 001009024.2_39722001_2 - 0.00024 20.6 0.0 0.00049 19.6 0.0 1.6 1 0 0 1 1 1 1 S4 domain HMG_box PF00505.17 214452.3_49822001_1 - 3.7e-25 88.0 1.5 5.6e-25 87.4 1.5 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 214452.3_49822001_1 - 1.6e-08 34.8 1.3 2.8e-08 34.1 1.3 1.4 1 0 0 1 1 1 1 HMG-box domain Neur_chan_LBD PF02931.21 001033934.1_39723001_1 - 5.4e-72 241.6 1.2 7e-72 241.2 1.2 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 001033934.1_39723001_1 - 1e-62 212.2 14.2 8.5e-49 166.6 10.6 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region CENP-O PF09496.8 001033934.1_39723001_1 - 0.19 11.6 0.3 0.34 10.8 0.1 1.4 2 0 0 2 2 2 0 Cenp-O kinetochore centromere component Filament PF00038.19 001009739.1_39524001_1 - 3.6e-96 322.3 16.4 4.7e-96 321.9 16.4 1.1 1 0 0 1 1 1 1 Intermediate filament protein Phage_Mu_Gam PF07352.10 001009739.1_39524001_1 - 0.001 18.9 8.7 0.11 12.3 0.1 3.5 3 0 0 3 3 3 2 Bacteriophage Mu Gam like protein V_ATPase_I PF01496.17 001009739.1_39524001_1 - 1.2 6.8 6.3 0.8 7.4 4.4 1.5 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family TPR_MLP1_2 PF07926.10 001009739.1_39524001_1 - 2.1 8.3 32.8 0.065 13.2 0.8 4.1 4 1 0 4 4 4 0 TPR/MLP1/MLP2-like protein DUF724 PF05266.12 001009739.1_39524001_1 - 2.6 7.7 7.9 1.4 8.6 3.8 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF724) FlxA PF14282.4 001009739.1_39524001_1 - 4.5 7.2 16.8 0.11 12.4 4.7 3.4 2 1 1 3 3 3 0 FlxA-like protein DUF4201 PF13870.4 001009739.1_39524001_1 - 4.8 6.7 21.4 1.1 8.7 2.5 4.2 3 1 1 4 4 4 0 Domain of unknown function (DUF4201) DUF4446 PF14584.4 001009739.1_39524001_1 - 8.1 6.3 8.7 6.2 6.7 0.0 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF4446) Reo_sigmaC PF04582.10 001009739.1_39524001_1 - 8.6 5.5 7.3 1.6 8.0 2.2 2.1 2 1 1 3 3 3 0 Reovirus sigma C capsid protein IPP-2 PF04979.12 138823.2_45725001_3 - 1.8e-41 141.8 7.6 3.1e-41 141.0 7.6 1.4 1 0 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) UQ_con PF00179.24 001082296.1_37922001_1 - 6.6e-53 178.0 0.1 8.2e-53 177.7 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.20 001082296.1_37922001_1 - 0.0044 17.2 0.1 0.0069 16.5 0.1 1.3 1 0 0 1 1 1 1 RWD domain CortBP2 PF09727.7 001168695.1_22429001_3 - 1.6e-38 132.4 38.8 2.7e-32 112.1 1.3 3.3 2 1 1 3 3 3 3 Cortactin-binding protein-2 Ank_2 PF12796.5 001168695.1_22429001_3 - 5.3e-38 129.4 4.3 1.9e-17 63.5 2.6 3.6 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001168695.1_22429001_3 - 1.6e-36 124.0 7.6 3.9e-12 46.3 0.1 5.4 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.4 001168695.1_22429001_3 - 1.2e-24 85.8 7.6 1.5e-08 34.6 0.0 5.8 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.28 001168695.1_22429001_3 - 3.2e-23 81.0 11.0 8.1e-05 22.8 0.0 6.5 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.4 001168695.1_22429001_3 - 1.4e-19 68.0 3.0 0.003 17.8 0.0 7.0 6 0 0 6 6 6 5 Ankyrin repeat S_100 PF01023.17 001168695.1_22429001_3 - 0.0082 15.7 0.7 0.59 9.8 0.1 2.6 2 0 0 2 2 2 1 S-100/ICaBP type calcium binding domain Pneumo_ncap PF03246.11 001168695.1_22429001_3 - 0.069 11.8 0.1 8 5.0 0.0 2.3 1 1 1 2 2 2 0 Pneumovirus nucleocapsid protein Spc7 PF08317.9 001168695.1_22429001_3 - 3.6 6.2 31.1 8.4 5.0 31.1 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein MHC_I PF00129.16 001045512.1_39723001_1 - 3.3e-93 310.1 1.8 4.5e-93 309.7 1.8 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001045512.1_39723001_1 - 7.6e-16 58.2 0.0 1.6e-15 57.2 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001045512.1_39723001_1 - 7.8e-14 51.2 7.2 1.6e-13 50.2 7.2 1.6 1 0 0 1 1 1 1 MHC_I C-terminus MHC_I_3 PF16497.3 001045512.1_39723001_1 - 0.00013 21.3 0.0 0.00019 20.8 0.0 1.3 1 0 0 1 1 1 1 MHC-I family domain C2-set_2 PF08205.10 001045512.1_39723001_1 - 0.023 14.6 0.3 0.052 13.5 0.0 1.7 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain ig PF00047.23 001045512.1_39723001_1 - 0.057 13.5 0.0 0.18 11.9 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin domain SNO PF01174.17 001045512.1_39723001_1 - 0.12 12.1 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 SNO glutamine amidotransferase family Pkinase PF00069.23 001101723.1_37927001_3 - 2.8e-60 203.8 0.0 3.9e-60 203.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001101723.1_37927001_3 - 2e-36 125.5 0.0 2.9e-36 125.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.20 001101723.1_37927001_3 - 1.6e-33 114.2 28.1 2.8e-17 62.2 5.8 2.7 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C2 PF00168.28 001101723.1_37927001_3 - 1.7e-26 92.4 0.1 3.3e-26 91.4 0.1 1.5 1 0 0 1 1 1 1 C2 domain Pkinase_C PF00433.22 001101723.1_37927001_3 - 0.00025 21.5 1.5 0.00057 20.4 1.5 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain C1_2 PF03107.14 001101723.1_37927001_3 - 0.0085 16.3 21.4 0.32 11.2 7.7 2.8 2 0 0 2 2 2 2 C1 domain Kinase-like PF14531.4 001101723.1_37927001_3 - 0.019 14.1 0.0 0.037 13.2 0.0 1.4 1 0 0 1 1 1 0 Kinase-like CEP76-C2 PF15627.4 001101723.1_37927001_3 - 0.02 14.3 0.0 0.036 13.5 0.0 1.3 1 0 0 1 1 1 0 CEP76 C2 domain APH PF01636.21 001101723.1_37927001_3 - 0.12 12.2 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family PHD_2 PF13831.4 001101723.1_37927001_3 - 0.25 10.8 13.0 1.3 8.4 1.1 3.0 2 0 0 2 2 2 0 PHD-finger PHD PF00628.27 001101723.1_37927001_3 - 3.5 7.5 21.2 2.4 8.0 4.1 2.7 2 0 0 2 2 2 0 PHD-finger Profilin PF00235.17 001109487.1_45722001_3 - 1.2e-18 67.4 0.0 1.5e-18 67.1 0.0 1.0 1 0 0 1 1 1 1 Profilin Aconitase PF00330.18 001082315.1_37928001_2 - 9e-181 601.7 0.0 1.1e-180 601.4 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.17 001082315.1_37928001_2 - 6.9e-48 162.2 0.0 6.4e-47 159.1 0.0 2.1 2 0 0 2 2 2 1 Aconitase C-terminal domain Phosducin PF02114.14 001043340.1_22422001_1 - 9.3e-133 441.0 2.0 1.1e-132 440.8 2.0 1.0 1 0 0 1 1 1 1 Phosducin Ig_3 PF13927.4 001037864.2_22423001_3 - 1.8e-24 86.0 2.0 3e-13 50.0 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001037864.2_22423001_3 - 1.1e-23 83.0 0.5 7.6e-11 41.9 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001037864.2_22423001_3 - 9.6e-19 67.1 0.0 3.7e-09 36.4 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 001037864.2_22423001_3 - 9e-17 61.1 0.8 6.5e-08 32.7 0.0 2.4 1 1 1 2 2 2 2 Immunoglobulin domain V-set PF07686.15 001037864.2_22423001_3 - 1.5e-14 53.9 1.2 1.2e-09 38.2 0.2 3.2 2 1 0 2 2 2 2 Immunoglobulin V-set domain C1-set PF07654.13 001037864.2_22423001_3 - 1.2e-06 28.8 0.1 0.02 15.2 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin C1-set domain Adeno_E3_CR1 PF02440.13 001037864.2_22423001_3 - 0.0066 16.1 0.2 0.014 15.0 0.2 1.5 1 0 0 1 1 1 1 Adenovirus E3 region protein CR1 V-set_CD47 PF08204.9 001037864.2_22423001_3 - 0.0069 16.2 0.5 0.2 11.5 0.1 2.2 2 0 0 2 2 2 1 CD47 immunoglobulin-like domain C2-set_2 PF08205.10 001037864.2_22423001_3 - 0.0069 16.3 0.1 0.081 12.9 0.0 2.3 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.3 001037864.2_22423001_3 - 0.088 12.7 0.0 3 7.8 0.0 2.2 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain 2Fe-2S_thioredx PF01257.17 001071786.1_39722001_1 - 1.7e-65 219.2 0.2 2e-65 218.9 0.2 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin S4 PF01479.23 001168878.1_40422001_1 - 1.6e-11 43.6 1.8 4.3e-11 42.2 1.8 1.8 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.17 001168878.1_40422001_1 - 7.4e-06 26.7 0.8 1.3e-05 26.0 0.1 1.8 1 1 1 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain UPAR_LY6 PF00021.19 001082712.1_37922001_1 - 0.0049 17.4 11.0 0.0049 17.4 11.0 2.2 2 1 0 2 2 2 1 u-PAR/Ly-6 domain 2-Hacid_dh_C PF02826.17 001098571.1_39724001_3 - 1e-58 197.5 0.0 1.9e-58 196.6 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.28 001098571.1_39724001_3 - 1.6e-39 134.5 0.0 2.3e-39 134.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain wnt PF00110.17 001082665.1_37923001_1 - 3.9e-121 404.2 24.5 4.5e-121 404.0 24.5 1.0 1 0 0 1 1 1 1 wnt family K_channel_TID PF07941.9 001082665.1_37923001_1 - 0.37 11.2 3.2 1.1 9.6 0.1 2.5 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain 7tm_1 PF00001.19 001082259.1_37927001_3 - 6.9e-34 117.2 6.1 8.6e-34 116.8 6.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001082259.1_37927001_3 - 4.7e-06 26.0 6.3 7.2e-06 25.4 6.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.7 001082259.1_37927001_3 - 0.0046 16.3 6.6 0.0046 16.3 6.6 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx NdhL PF10716.7 001082259.1_37927001_3 - 0.048 13.5 1.3 0.082 12.8 0.0 2.0 2 0 0 2 2 2 0 NADH dehydrogenase transmembrane subunit adh_short_C2 PF13561.4 001082218.1_37923001_1 - 4.4e-62 209.6 1.2 6.4e-62 209.0 1.2 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.23 001082218.1_37923001_1 - 4.3e-52 176.3 1.9 5.4e-52 176.0 1.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.8 001082218.1_37923001_1 - 2.7e-10 40.3 1.2 4.3e-10 39.7 1.2 1.2 1 0 0 1 1 1 1 KR domain YjeF_N PF03853.13 001082218.1_37923001_1 - 0.037 13.8 0.3 0.067 12.9 0.3 1.4 1 0 0 1 1 1 0 YjeF-related protein N-terminus DFP PF04127.13 001082218.1_37923001_1 - 0.14 11.9 2.2 0.24 11.1 0.8 1.9 1 1 1 2 2 2 0 DNA / pantothenate metabolism flavoprotein TLD PF07534.14 001045497.2_39724001_1 - 2.9e-05 24.2 0.0 0.00025 21.2 0.0 2.2 1 1 0 1 1 1 1 TLD MMR_HSR1 PF01926.21 001045497.2_39724001_1 - 0.0079 16.1 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.4 001045497.2_39724001_1 - 0.031 13.9 0.0 0.071 12.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF258 PF03193.14 001045497.2_39724001_1 - 0.033 13.9 0.3 0.17 11.7 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Aldo_ket_red PF00248.19 001082250.1_37923001_3 - 6.9e-57 192.7 0.0 8.5e-57 192.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family LRR_8 PF13855.4 001082330.1_37924001_1 - 4.7e-42 141.4 13.1 2.1e-15 56.1 2.4 4.5 4 0 0 4 4 4 3 Leucine rich repeat LRR_4 PF12799.5 001082330.1_37924001_1 - 5.9e-19 67.7 26.0 0.00018 21.6 2.9 7.1 2 1 6 9 9 9 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001082330.1_37924001_1 - 3.2e-12 46.4 1.5 6.2e-05 22.8 0.1 2.9 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001082330.1_37924001_1 - 2.1e-10 40.3 4.8 1.7e-05 24.3 1.7 2.9 1 1 2 3 3 3 3 Leucine-rich repeat LRRNT PF01462.16 001082330.1_37924001_1 - 6.5e-10 38.3 5.6 6.5e-10 38.3 5.6 2.1 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.31 001082330.1_37924001_1 - 0.00014 21.8 10.1 17 6.2 0.1 6.9 7 1 0 7 7 7 1 Leucine Rich Repeat LRR_6 PF13516.4 001082330.1_37924001_1 - 0.0002 21.0 16.2 0.71 9.9 0.0 7.2 8 0 0 8 8 8 3 Leucine Rich repeat Sec16_C PF12931.5 001082014.1_37928001_1 - 9.7e-44 150.1 0.0 2.2e-43 148.9 0.0 1.5 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.5 001082014.1_37928001_1 - 2.9e-06 27.7 0.0 6.3e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region DAO PF01266.22 001082382.1_37925001_1 - 7e-48 163.8 0.0 8.6e-48 163.5 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.4 001082382.1_37925001_1 - 0.0031 17.6 1.9 0.006 16.7 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.12 001082382.1_37925001_1 - 0.036 12.6 0.0 4 5.9 0.0 2.4 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox_2 PF07992.12 001082382.1_37925001_1 - 0.048 12.8 0.0 1.6 7.8 0.0 2.7 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase COesterase PF00135.26 001082765.2_37924001_2 - 8.3e-164 546.1 0.0 9.5e-164 546.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.11 001082765.2_37924001_2 - 7.4e-11 42.2 1.3 4.3e-10 39.7 1.0 2.3 2 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.19 001082765.2_37924001_2 - 0.00027 20.3 0.0 0.00056 19.3 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.7 001082765.2_37924001_2 - 0.024 13.4 0.0 0.088 11.5 0.0 1.8 1 1 0 1 1 1 0 Steryl acetyl hydrolase Esterase PF00756.18 001082765.2_37924001_2 - 0.026 14.0 0.3 0.1 12.1 0.3 1.8 1 1 0 1 1 1 0 Putative esterase Ank_2 PF12796.5 001112614.1_40424001_2 - 1.7e-32 111.7 3.2 1.2e-15 57.8 0.3 3.4 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001112614.1_40424001_2 - 2.4e-23 81.7 1.0 1.1e-09 38.2 0.0 4.9 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.28 001112614.1_40424001_2 - 3.2e-23 81.0 0.6 6.8e-06 26.2 0.0 5.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.4 001112614.1_40424001_2 - 1.6e-20 73.1 0.1 1.4e-11 44.5 0.0 3.8 1 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.4 001112614.1_40424001_2 - 3.2e-20 69.9 0.2 0.00022 21.3 0.0 5.9 6 0 0 6 6 6 4 Ankyrin repeat SAM_2 PF07647.15 001112614.1_40424001_2 - 8.7e-08 32.0 0.2 2.1e-07 30.8 0.2 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 001112614.1_40424001_2 - 9.2e-07 29.1 0.3 2.3e-06 27.8 0.3 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PMP22_Claudin PF00822.18 001082357.1_37926001_3 - 2.1e-54 183.7 16.7 3.3e-54 183.1 16.7 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001082357.1_37926001_3 - 0.0014 18.3 8.4 0.0014 18.3 8.4 2.8 3 1 0 3 3 3 1 PMP-22/EMP/MP20/Claudin tight junction Amastin PF07344.9 001082357.1_37926001_3 - 0.23 11.1 14.4 0.51 10.0 14.1 1.7 1 1 0 1 1 1 0 Amastin surface glycoprotein ADH_zinc_N PF00107.24 001082624.1_37923001_3 - 2e-27 95.5 0.4 3.7e-27 94.6 0.4 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 001082624.1_37923001_3 - 1.1e-23 83.0 1.3 1.1e-23 83.0 1.3 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.3 001082624.1_37923001_3 - 3.7e-05 23.2 0.3 0.0002 20.8 0.3 1.9 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.4 001082624.1_37923001_3 - 0.00063 20.6 0.0 0.0018 19.2 0.0 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.12 001082624.1_37923001_3 - 0.018 14.5 0.0 0.029 13.8 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.19 001082624.1_37923001_3 - 0.018 14.2 0.4 0.034 13.3 0.4 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Ion_trans PF00520.29 001082358.1_37929001_1 - 8.2e-257 847.1 100.3 3.6e-81 271.9 15.3 4.1 4 0 0 4 4 4 4 Ion transport protein Na_trans_cytopl PF11933.6 001082358.1_37929001_1 - 6.1e-73 245.0 11.6 6.1e-73 245.0 11.6 1.8 2 0 0 2 2 2 1 Cytoplasmic domain of voltage-gated Na+ ion channel Na_trans_assoc PF06512.11 001082358.1_37929001_1 - 9.7e-57 192.2 4.5 9.7e-57 192.2 4.5 3.1 4 0 0 4 4 4 1 Sodium ion transport-associated GPHH PF16905.3 001082358.1_37929001_1 - 1.7e-06 27.6 0.0 3.9e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.10 001082358.1_37929001_1 - 0.00011 20.9 88.1 0.00077 18.1 1.9 9.7 7 3 2 9 9 9 6 Polycystin cation channel IQ PF00612.25 001082358.1_37929001_1 - 0.0037 16.8 0.6 0.0087 15.6 0.6 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif Lustrin_cystein PF14625.4 001082358.1_37929001_1 - 0.024 14.9 0.2 0.074 13.3 0.2 1.8 1 0 0 1 1 1 0 Lustrin, cysteine-rich repeated domain Zip PF02535.20 001082358.1_37929001_1 - 0.048 12.7 3.7 0.12 11.4 0.1 3.2 2 0 0 2 2 2 0 ZIP Zinc transporter SurA_N_3 PF13624.4 001082358.1_37929001_1 - 2.1 8.0 7.9 6.2 6.5 0.1 4.4 4 0 0 4 4 4 0 SurA N-terminal domain CDC14 PF08045.9 001082358.1_37929001_1 - 2.6 7.0 9.2 0.11 11.5 0.3 2.6 2 0 0 2 2 2 0 Cell division control protein 14, SIN component GST_C_2 PF13410.4 001082004.1_37925001_1 - 6e-06 26.0 0.0 1.4e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 001082004.1_37925001_1 - 0.00019 21.6 0.0 0.00036 20.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 001082004.1_37925001_1 - 0.0003 20.9 0.0 0.00051 20.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.4 001082004.1_37925001_1 - 0.11 12.6 0.1 0.23 11.6 0.1 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 001082004.1_37925001_1 - 0.13 12.4 0.1 0.28 11.3 0.1 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF342 PF03961.11 001082004.1_37925001_1 - 0.22 9.9 13.2 0.66 8.4 13.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF342) Ammonium_transp PF00909.19 001082729.1_37924001_1 - 4.5e-77 259.3 15.7 5.8e-77 258.9 15.7 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF4293 PF14126.4 001082729.1_37924001_1 - 0.0002 21.6 1.9 0.0007 19.7 1.1 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4293) Calsequestrin PF01216.15 001101691.1_37926001_2 - 7.6e-230 762.4 19.8 1.1e-229 761.9 19.8 1.2 1 0 0 1 1 1 1 Calsequestrin Thioredoxin_6 PF13848.4 001101691.1_37926001_2 - 2.1e-19 70.1 9.2 1.4e-17 64.2 2.7 2.6 2 1 1 3 3 3 3 Thioredoxin-like domain SDA1 PF05285.10 001101691.1_37926001_2 - 0.023 14.0 11.2 0.032 13.5 11.2 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.10 001101691.1_37926001_2 - 8 4.4 17.3 11 3.9 17.3 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.12 001101691.1_37926001_2 - 9.1 4.3 13.2 14 3.7 13.2 1.1 1 0 0 1 1 1 0 CDC45-like protein wnt PF00110.17 001168718.1_40425001_2 - 2e-121 405.1 25.2 2.4e-121 404.8 25.2 1.1 1 0 0 1 1 1 1 wnt family EF-hand_1 PF00036.30 001082761.1_37922001_2 - 1.9e-09 36.2 2.8 1.8e-05 23.8 0.9 4.4 5 0 0 5 5 5 2 EF hand EF-hand_7 PF13499.4 001082761.1_37922001_2 - 1.7e-08 34.7 0.1 0.00069 19.9 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 001082761.1_37922001_2 - 6.2e-08 31.9 1.8 2.4e-05 23.8 0.4 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.4 001082761.1_37922001_2 - 1.2e-05 24.8 1.7 0.0044 16.6 0.4 3.6 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.4 001082761.1_37922001_2 - 0.0003 20.1 1.1 0.0003 20.1 1.1 2.2 2 0 0 2 2 2 1 EF hand NO_synthase PF02898.13 001082385.1_37929001_3 - 5e-194 644.2 0.0 7.5e-194 643.6 0.0 1.3 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain FAD_binding_1 PF00667.18 001082385.1_37929001_3 - 5.3e-88 294.2 0.0 9e-88 293.4 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.23 001082385.1_37929001_3 - 7.3e-55 185.0 0.1 1.9e-54 183.6 0.0 1.8 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.19 001082385.1_37929001_3 - 3.8e-20 72.4 0.1 1.2e-19 70.8 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain PDZ PF00595.22 001082385.1_37929001_3 - 3.8e-16 59.1 0.0 1.8e-15 56.9 0.1 2.1 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001082385.1_37929001_3 - 0.00041 20.5 0.0 0.00099 19.2 0.0 1.7 1 0 0 1 1 1 1 PDZ domain Flavodoxin_5 PF12724.5 001082385.1_37929001_3 - 0.17 12.0 0.0 0.72 10.0 0.0 2.1 2 0 0 2 2 2 0 Flavodoxin domain ABC_membrane PF00664.21 001082083.1_37929001_2 - 8.9e-125 415.7 21.8 2.7e-64 217.3 6.0 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 001082083.1_37929001_2 - 2.6e-70 235.2 0.1 6.8e-34 117.2 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 001082083.1_37929001_2 - 2.1e-13 50.1 0.8 6.5e-06 25.6 0.1 3.5 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 001082083.1_37929001_2 - 5.4e-08 33.3 0.0 0.0028 17.9 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain DUF258 PF03193.14 001082083.1_37929001_2 - 7.3e-08 32.4 0.0 0.0035 17.1 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_29 PF13555.4 001082083.1_37929001_2 - 5.4e-07 29.1 0.2 0.0058 16.2 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.4 001082083.1_37929001_2 - 9.5e-07 29.0 0.0 0.11 12.7 0.0 3.0 2 1 0 2 2 2 2 AAA domain Zeta_toxin PF06414.10 001082083.1_37929001_2 - 1.6e-05 24.2 0.0 0.051 12.7 0.0 3.0 3 0 0 3 3 3 2 Zeta toxin AAA_15 PF13175.4 001082083.1_37929001_2 - 1.8e-05 24.4 0.6 0.15 11.5 0.0 2.6 3 0 0 3 3 3 2 AAA ATPase domain AAA_30 PF13604.4 001082083.1_37929001_2 - 3e-05 23.7 0.0 0.12 12.0 0.0 2.8 2 1 0 2 2 2 2 AAA domain ABC_ATPase PF09818.7 001082083.1_37929001_2 - 0.00024 19.9 1.4 0.81 8.3 0.1 3.1 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_33 PF13671.4 001082083.1_37929001_2 - 0.00031 20.8 0.0 0.12 12.3 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_21 PF13304.4 001082083.1_37929001_2 - 0.0012 18.6 0.0 0.049 13.3 0.0 2.9 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.13 001082083.1_37929001_2 - 0.0012 17.7 0.0 0.32 9.7 0.0 2.2 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein G-alpha PF00503.18 001082083.1_37929001_2 - 0.0034 16.5 0.0 0.89 8.5 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit AAA_5 PF07728.12 001082083.1_37929001_2 - 0.016 15.1 0.0 2.8 7.8 0.0 2.9 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_23 PF13476.4 001082083.1_37929001_2 - 0.017 15.5 0.5 0.39 11.1 0.0 2.7 3 0 0 3 3 2 0 AAA domain AAA_28 PF13521.4 001082083.1_37929001_2 - 0.069 13.3 0.0 11 6.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.20 001082083.1_37929001_2 - 0.071 13.4 0.0 16 5.8 0.0 2.9 2 0 0 2 2 2 0 RNA helicase SRP54 PF00448.20 001082083.1_37929001_2 - 0.087 12.3 0.0 3.1 7.2 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_25 PF13481.4 001082083.1_37929001_2 - 0.1 12.0 1.4 1.1 8.6 0.0 2.9 4 0 0 4 4 4 0 AAA domain Dala_Dala_lig_N PF01820.19 001082083.1_37929001_2 - 0.12 12.3 0.1 2.1 8.4 0.0 2.5 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus SbcCD_C PF13558.4 001082083.1_37929001_2 - 0.37 10.9 3.4 4.8 7.3 0.2 3.3 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit VWD PF00094.23 001082081.1_37929001_1 - 1.5e-146 483.4 0.2 6.1e-39 133.7 0.1 4.5 4 0 0 4 4 4 4 von Willebrand factor type D domain TILa PF12714.5 001082081.1_37929001_1 - 9.9e-72 236.6 89.7 4.8e-19 67.9 13.4 10.1 8 1 1 9 9 9 5 TILa domain C8 PF08742.9 001082081.1_37929001_1 - 6.6e-62 205.7 43.5 3.2e-19 69.0 3.0 6.9 5 0 0 5 5 5 4 C8 domain MAM PF00629.21 001082081.1_37929001_1 - 6.3e-47 159.3 0.0 2.7e-31 108.5 0.0 2.8 3 0 0 3 3 3 2 MAM domain, meprin/A5/mu TIL PF01826.15 001082081.1_37929001_1 - 1.3e-41 140.5 108.3 1.1e-12 47.8 14.9 13.9 13 2 2 15 15 15 5 Trypsin Inhibitor like cysteine rich domain hEGF PF12661.5 001082081.1_37929001_1 - 0.0012 19.3 5.7 0.0012 19.3 5.7 10.7 9 0 0 9 9 9 1 Human growth factor-like EGF Calcipressin PF04847.10 001105241.1_39727001_2 - 6.9e-64 214.9 0.3 9.5e-64 214.4 0.3 1.2 1 0 0 1 1 1 1 Calcipressin RRM_1 PF00076.20 001105241.1_39727001_2 - 0.084 12.6 0.4 0.15 11.7 0.4 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PDZ PF00595.22 019518.3_32925001_3 - 2.8e-12 46.7 0.0 4.5e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 019518.3_32925001_3 - 0.00019 21.5 0.0 0.00038 20.6 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Caveolin PF01146.15 001171022.1_37926001_1 - 1.2e-53 180.5 0.3 1.9e-53 179.8 0.3 1.2 1 0 0 1 1 1 1 Caveolin Annexin PF00191.18 001082019.1_37923001_3 - 1.3e-96 316.5 14.9 1.6e-24 85.6 0.6 4.1 4 0 0 4 4 4 4 Annexin Myb_DNA-bind_7 PF15963.3 001082019.1_37923001_3 - 0.0011 18.6 0.2 5.7 6.8 0.0 3.3 3 0 0 3 3 3 1 Myb DNA-binding like DUF445 PF04286.10 001082019.1_37923001_3 - 0.025 14.2 0.0 0.094 12.4 0.0 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF445) DUF3500 PF12006.6 001082019.1_37923001_3 - 0.042 13.2 0.0 0.065 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3500) DUF3102 PF11300.6 001082019.1_37923001_3 - 0.078 13.1 0.1 0.52 10.4 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3102) TINF2_N PF14973.4 001082019.1_37923001_3 - 0.18 12.0 0.9 14 5.9 0.0 2.9 2 1 1 3 3 3 0 TERF1-interacting nuclear factor 2 N-terminus PBP PF01161.18 001082143.1_37922001_2 - 2.2e-16 60.2 0.0 3.1e-16 59.8 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Oxidored_q6 PF01058.20 001110243.1_39722001_1 - 5.2e-24 84.4 0.1 7.6e-24 83.9 0.1 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit WAP PF00095.19 001135854.1_39723001_2 - 1.1e-14 54.4 39.3 5.8e-08 32.9 16.7 2.3 2 0 0 2 2 2 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' Filament PF00038.19 001110814.1_39724001_1 - 8e-115 383.6 36.8 8e-115 383.6 36.8 1.5 2 0 0 2 2 2 1 Intermediate filament protein Keratin_2_head PF16208.3 001110814.1_39724001_1 - 3.6e-10 40.1 19.5 1.2e-08 35.2 0.1 3.1 2 1 1 3 3 3 2 Keratin type II head TPR_MLP1_2 PF07926.10 001110814.1_39724001_1 - 5.4e-06 26.4 0.7 5.4e-06 26.4 0.7 4.9 4 1 1 5 5 5 2 TPR/MLP1/MLP2-like protein JAKMIP_CC3 PF16034.3 001110814.1_39724001_1 - 0.0039 17.0 10.8 0.0039 17.0 10.8 4.8 2 1 3 5 5 5 1 JAKMIP CC3 domain Reo_sigmaC PF04582.10 001110814.1_39724001_1 - 0.0067 15.7 6.2 0.3 10.3 1.2 2.4 2 0 0 2 2 2 2 Reovirus sigma C capsid protein Baculo_PEP_C PF04513.10 001110814.1_39724001_1 - 0.18 11.7 15.1 2.2 8.2 4.9 3.5 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus NPV_P10 PF05531.10 001110814.1_39724001_1 - 1.7 9.1 13.5 4.7 7.6 0.1 4.4 3 1 3 6 6 6 0 Nucleopolyhedrovirus P10 protein Sugar_tr PF00083.22 001168755.1_40424001_1 - 1.9e-24 86.2 26.7 2.9e-24 85.6 26.7 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001168755.1_40424001_1 - 1.1e-23 83.6 65.1 7.4e-21 74.3 39.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Carb_anhydrase PF00194.19 001082372.1_37923001_3 - 9.2e-85 284.1 0.0 1.1e-84 283.9 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase FKBP_C PF00254.26 001082310.1_37925001_1 - 1.6e-47 159.6 0.0 4.7e-31 106.8 0.0 2.3 2 0 0 2 2 2 2 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.26 001082310.1_37925001_1 - 4.8e-19 67.2 4.8 1.2e-06 27.9 0.1 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.15 001082310.1_37925001_1 - 1.7e-15 55.7 4.1 1.2e-05 24.9 0.0 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.4 001082310.1_37925001_1 - 1.8e-10 40.1 2.8 0.002 18.1 0.1 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.4 001082310.1_37925001_1 - 5e-08 33.0 2.2 0.0013 18.8 0.9 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.4 001082310.1_37925001_1 - 4e-07 29.5 3.0 0.022 14.3 0.0 3.4 2 1 1 3 3 3 2 TPR repeat TPR_6 PF13174.4 001082310.1_37925001_1 - 1.2e-06 28.7 4.7 0.004 17.5 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.4 001082310.1_37925001_1 - 1e-05 26.0 2.5 0.39 11.3 0.5 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.4 001082310.1_37925001_1 - 3.6e-05 24.1 5.9 0.03 14.7 0.5 2.7 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.4 001082310.1_37925001_1 - 5e-05 23.7 0.9 0.015 16.0 0.3 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.4 001082310.1_37925001_1 - 0.00043 20.0 1.3 0.77 9.8 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.4 001082310.1_37925001_1 - 0.00083 19.3 0.2 0.0089 16.0 0.2 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat PknG_TPR PF16918.3 001082310.1_37925001_1 - 0.0017 17.0 0.6 0.0025 16.4 0.6 1.2 1 0 0 1 1 1 1 Protein kinase G tetratricopeptide repeat OmpH PF03938.12 001082310.1_37925001_1 - 0.0019 18.1 4.7 0.0039 17.1 4.7 1.5 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) TPR_17 PF13431.4 001082310.1_37925001_1 - 0.016 15.4 3.0 0.28 11.6 0.1 3.4 4 0 0 4 4 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.4 001082310.1_37925001_1 - 0.48 10.4 6.4 2.2 8.3 0.1 2.9 2 1 1 3 3 2 0 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.5 001082310.1_37925001_1 - 0.54 10.4 7.4 5.9 7.0 0.1 2.8 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Piwi PF02171.15 001082710.1_37928001_1 - 7.4e-114 379.9 0.0 1.1e-113 379.4 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoMid PF16487.3 001082710.1_37928001_1 - 1.6e-32 111.5 0.5 6e-32 109.6 0.1 2.3 2 0 0 2 2 2 1 Mid domain of argonaute ArgoN PF16486.3 001082710.1_37928001_1 - 1.9e-29 102.9 0.0 4.5e-29 101.6 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of argonaute PAZ PF02170.20 001082710.1_37928001_1 - 5.2e-28 97.4 1.4 8.4e-28 96.8 1.4 1.3 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.8 001082710.1_37928001_1 - 7.6e-22 76.6 0.1 1.6e-21 75.6 0.1 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain UDPGT PF00201.16 001082710.1_37928001_1 - 6.4e-21 74.6 0.0 8.7e-21 74.1 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase ArgoL2 PF16488.3 001082710.1_37928001_1 - 4.1e-13 49.3 0.0 8.1e-13 48.4 0.0 1.5 1 0 0 1 1 1 1 Argonaute linker 2 domain Cullin PF00888.20 001082355.1_37927001_1 - 8.2e-186 619.1 17.8 1.1e-185 618.7 17.8 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.7 001082355.1_37927001_1 - 5.2e-16 58.3 6.9 1.5e-15 56.9 6.9 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain HMD PF03201.14 001082355.1_37927001_1 - 0.27 11.4 2.3 0.82 9.8 0.2 2.9 2 0 0 2 2 2 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase Complex1_51K PF01512.15 001071825.1_39723001_1 - 7.1e-50 168.7 0.0 1.2e-49 168.0 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.7 001071825.1_39723001_1 - 7e-31 106.0 0.2 2.9e-30 104.0 0.0 2.0 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.7 001071825.1_39723001_1 - 1.7e-07 30.9 0.0 3.3e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 SLBB domain Crystall PF00030.17 001078681.1_49822001_1 - 1.1e-58 195.3 2.4 2e-28 98.3 0.2 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 001078681.1_49822001_1 - 2.7e-11 43.1 0.0 5.5e-06 26.1 0.1 2.5 2 1 0 2 2 2 2 Peptidase inhibitor family I36 Crystall_3 PF08964.8 001078681.1_49822001_1 - 5.5e-05 23.1 0.2 0.52 10.4 0.0 2.9 2 1 1 3 3 3 2 Beta/Gamma crystallin P53 PF00870.16 001082404.1_37925001_1 - 1.6e-114 380.2 1.3 2.4e-114 379.7 1.3 1.2 1 0 0 1 1 1 1 P53 DNA-binding domain P53_tetramer PF07710.9 001082404.1_37925001_1 - 1.2e-16 59.6 3.9 2.2e-16 58.7 3.9 1.4 1 0 0 1 1 1 1 P53 tetramerisation motif P53_TAD PF08563.9 001082404.1_37925001_1 - 1.8e-12 46.2 7.0 3.6e-12 45.2 7.0 1.6 1 0 0 1 1 1 1 P53 transactivation motif DEC-1_N PF04625.11 001082404.1_37925001_1 - 1 8.2 3.7 1.5 7.6 3.7 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Collagen PF01391.16 001082404.1_37925001_3 - 0.92 9.2 11.4 2.2 8.0 5.6 2.4 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) Caveolin PF01146.15 001024163.1_22426001_3 - 6.9e-59 197.4 2.1 6.9e-59 197.4 2.1 1.9 2 0 0 2 2 2 1 Caveolin GSHPx PF00255.17 001077512.2_39722001_2 - 1.7e-37 127.1 0.0 2.2e-37 126.8 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase Serpin PF00079.18 001082185.1_37923001_1 - 2.3e-118 395.6 0.1 2.6e-118 395.4 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Lys PF00062.18 001082052.1_37922001_3 - 3.6e-52 175.7 5.6 5e-52 175.2 5.6 1.1 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family Rubis-subs-bind PF09273.9 001169078.1_40424001_1 - 2.3e-33 115.5 0.1 4.8e-33 114.5 0.1 1.6 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.26 001169078.1_40424001_1 - 1e-15 58.4 0.1 4.8e-14 53.0 0.0 2.4 2 0 0 2 2 2 1 SET domain Fibroin_P25 PF07294.9 001169078.1_40424001_1 - 0.094 12.6 0.4 0.35 10.8 0.4 1.8 1 1 1 2 2 2 0 Fibroin P25 Pertussis_S2S3 PF02918.13 001169078.1_40424001_1 - 0.14 11.9 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 Pertussis toxin, subunit 2 and 3, C-terminal domain Na_H_Exchanger PF00999.19 001101721.1_37928001_2 - 5.3e-88 295.2 46.3 7.1e-88 294.8 46.3 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family NEXCaM_BD PF16644.3 001101721.1_37928001_2 - 1.5e-31 108.8 6.3 2.9e-31 107.9 6.3 1.5 1 0 0 1 1 1 1 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin Integrin_beta PF00362.16 001082304.1_37926001_1 - 9.4e-104 346.3 0.0 1.5e-103 345.7 0.0 1.3 1 0 0 1 1 1 1 Integrin beta chain VWA domain PSI_integrin PF17205.1 001082304.1_37926001_1 - 3.7e-12 45.7 3.4 3.7e-12 45.7 3.4 4.2 4 0 0 4 4 4 1 Integrin plexin domain EGF_2 PF07974.11 001082304.1_37926001_1 - 2.7e-07 30.7 54.6 5.7e-05 23.3 13.0 5.8 6 0 0 6 6 6 3 EGF-like domain FH2 PF02181.21 172409.2_32929001_3 - 1.6e-104 349.8 13.1 1.6e-104 349.8 13.1 2.7 3 0 0 3 3 3 2 Formin Homology 2 Domain Drf_FH3 PF06367.14 172409.2_32929001_3 - 2.4e-48 164.2 16.6 2.4e-48 164.2 16.6 2.1 2 0 0 2 2 2 1 Diaphanous FH3 Domain Drf_GBD PF06371.11 172409.2_32929001_3 - 2.9e-25 88.8 2.1 3.5e-13 49.4 0.0 5.0 4 1 1 5 5 5 2 Diaphanous GTPase-binding Domain DUF1664 PF07889.10 172409.2_32929001_3 - 3.5 7.5 11.3 17 5.3 11.3 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Sod_Cu PF00080.18 001082632.1_37922001_1 - 3.1e-29 101.8 0.0 4.3e-29 101.4 0.0 1.2 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) 7tm_1 PF00001.19 001033932.2_39723001_1 - 4.5e-67 226.0 9.6 7.3e-67 225.3 9.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001033932.2_39723001_1 - 6.8e-16 58.3 10.5 1.3e-15 57.3 10.5 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001033932.2_39723001_1 - 6e-07 29.3 8.1 6e-07 29.3 8.1 2.2 2 1 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001033932.2_39723001_1 - 0.00092 18.5 16.2 0.00092 18.5 16.2 2.9 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF1385 PF07136.9 001033932.2_39723001_1 - 0.0053 15.9 0.0 0.0053 15.9 0.0 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF1385) UPF0182 PF03699.11 001033932.2_39723001_1 - 0.016 13.2 1.5 0.027 12.5 1.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) Pox_P21 PF05313.10 001033932.2_39723001_1 - 0.19 11.1 14.2 0.11 11.9 0.8 3.4 3 1 0 3 3 3 0 Poxvirus P21 membrane protein DUF4834 PF16118.3 001033932.2_39723001_1 - 1.6 9.6 0.0 1.6 9.6 0.0 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4834) V-set PF07686.15 001110821.1_39723001_2 - 2.8e-15 56.3 0.2 4.1e-15 55.7 0.2 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain zf-CCHC_3 PF13917.4 001271026.1_45723001_2 - 6.6e-18 64.3 5.5 1.2e-17 63.5 5.5 1.4 1 0 0 1 1 1 1 Zinc knuckle Mem_trans PF03547.16 001271026.1_45723001_2 - 0.0075 14.6 0.0 0.04 12.2 0.0 1.9 1 1 0 1 1 1 1 Membrane transport protein SPX PF03105.17 001271026.1_45723001_2 - 0.43 10.3 37.3 0.62 9.8 37.3 1.1 1 0 0 1 1 1 0 SPX domain Macoilin PF09726.7 001271026.1_45723001_2 - 0.66 8.3 31.7 0.81 8.0 31.7 1.1 1 0 0 1 1 1 0 Transmembrane protein Apt1 PF10351.7 001271026.1_45723001_2 - 2.5 6.7 30.6 3.4 6.3 30.6 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain SAPS PF04499.13 001271026.1_45723001_2 - 4.5 5.8 13.5 5.7 5.5 13.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein BUD22 PF09073.8 001271026.1_45723001_2 - 8.9 5.4 39.0 12 5.0 39.0 1.1 1 0 0 1 1 1 0 BUD22 Sugar_tr PF00083.22 001105687.1_37925001_1 - 7e-161 535.9 21.8 8.9e-161 535.6 21.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001105687.1_37925001_1 - 3.5e-19 68.8 28.3 1.1e-17 63.8 23.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.11 001105687.1_37925001_1 - 0.0093 14.3 2.6 0.016 13.5 2.6 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF2127 PF09900.7 001105687.1_37925001_1 - 0.11 12.7 4.8 0.042 14.0 1.5 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2127) DUF523 PF04463.10 001105687.1_37925001_1 - 0.16 11.9 0.1 0.27 11.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF523) Hanta_G1 PF01567.14 001105687.1_37925001_1 - 0.16 10.5 0.7 2.8 6.4 0.9 2.3 2 0 0 2 2 2 0 Hantavirus glycoprotein G1 Pox_EPC_I2-L1 PF12575.6 001105687.1_37925001_1 - 0.35 11.0 2.3 1.3 9.2 2.3 2.0 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 Filament PF00038.19 001076917.1_06525001_3 - 8.7e-116 386.7 33.3 1e-115 386.5 33.3 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001076917.1_06525001_3 - 2.2e-30 105.8 32.5 2.2e-30 105.8 32.5 3.1 2 1 0 2 2 2 1 Keratin type II head TPR_MLP1_2 PF07926.10 001076917.1_06525001_3 - 3.1e-06 27.1 27.9 0.0015 18.5 11.2 3.5 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein AAA_13 PF13166.4 001076917.1_06525001_3 - 6.1e-05 21.8 13.1 6.1e-05 21.8 13.1 1.4 1 1 0 1 1 1 1 AAA domain CENP-F_leu_zip PF10473.7 001076917.1_06525001_3 - 0.00012 22.0 22.7 0.0041 17.0 3.8 3.3 1 1 1 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.9 001076917.1_06525001_3 - 0.0045 15.8 31.1 0.072 11.8 14.0 2.9 1 1 1 2 2 2 2 Spc7 kinetochore protein Jnk-SapK_ap_N PF09744.7 001076917.1_06525001_3 - 0.0088 16.1 2.8 0.0088 16.1 2.8 3.4 2 1 1 3 3 3 1 JNK_SAPK-associated protein-1 Alanine_zipper PF11839.6 001076917.1_06525001_3 - 0.016 15.4 3.5 0.016 15.4 3.5 2.0 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein IncA PF04156.12 001076917.1_06525001_3 - 0.042 13.5 30.3 0.028 14.1 10.4 3.1 1 1 1 3 3 3 0 IncA protein Tropomyosin_1 PF12718.5 001076917.1_06525001_3 - 0.12 12.4 24.5 0.02 14.9 9.2 3.5 3 1 1 4 4 4 0 Tropomyosin like Reo_sigmaC PF04582.10 001076917.1_06525001_3 - 0.12 11.6 7.8 2.7 7.2 0.8 2.7 1 1 2 3 3 3 0 Reovirus sigma C capsid protein ADIP PF11559.6 001076917.1_06525001_3 - 0.47 10.4 27.0 0.036 14.0 8.3 3.5 1 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Tup_N PF08581.8 001076917.1_06525001_3 - 1.2 9.3 20.0 3.1 8.0 0.1 5.1 2 2 4 6 6 6 0 Tup N-terminal DUF5082 PF16888.3 001076917.1_06525001_3 - 1.2 9.3 19.3 0.1 12.8 3.0 4.0 1 1 3 4 4 4 0 Domain of unknown function (DUF5082) CHDCT2 PF08074.9 001076917.1_06525001_3 - 1.4 9.0 13.6 2.1 8.3 0.8 2.7 1 1 0 2 2 2 0 CHDCT2 (NUC038) domain RPW8 PF05659.9 001076917.1_06525001_3 - 3 7.4 8.0 11 5.5 0.3 3.0 2 1 1 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Baculo_PEP_C PF04513.10 001076917.1_06525001_3 - 4.5 7.2 20.0 1.6 8.6 2.8 3.9 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Virulence_fact PF13769.4 001076917.1_06525001_3 - 5.3 7.1 7.4 3.9 7.5 0.4 3.1 2 1 1 3 3 3 0 Virulence factor DUF1664 PF07889.10 001076917.1_06525001_3 - 5.4 6.9 12.0 5 7.0 1.4 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) Bap31 PF05529.10 001076917.1_06525001_3 - 6 6.3 16.6 0.021 14.3 2.6 3.0 1 1 1 3 3 3 0 B-cell receptor-associated protein 31-like Golgin_A5 PF09787.7 001076917.1_06525001_3 - 6.6 6.0 27.8 0.11 11.8 8.8 3.1 1 1 3 4 4 4 0 Golgin subfamily A member 5 DASH_Duo1 PF08651.8 001076917.1_06525001_3 - 7 6.4 7.1 14 5.4 0.8 3.4 3 0 0 3 3 3 0 DASH complex subunit Duo1 7tm_1 PF00001.19 001082678.1_37924001_1 - 5.6e-78 261.7 3.8 7e-78 261.4 3.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001082678.1_37924001_1 - 3.2e-13 49.5 1.5 4.5e-13 49.0 1.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001082678.1_37924001_1 - 4.7e-05 22.7 3.4 9.4e-05 21.7 3.4 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001082678.1_37924001_1 - 0.00049 19.8 3.7 0.00049 19.8 3.7 2.4 3 0 0 3 3 3 1 Olfactory receptor 7TM_GPCR_Srv PF10323.7 001082678.1_37924001_1 - 0.0027 17.0 0.8 0.0076 15.5 0.1 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv Arginase PF00491.19 001082108.1_37923001_2 - 8.7e-77 258.2 0.0 1.1e-76 257.9 0.0 1.0 1 0 0 1 1 1 1 Arginase family HIT PF01230.21 001082623.1_37921001_3 - 2.4e-31 108.2 0.0 3e-31 107.9 0.0 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.6 001082623.1_37921001_3 - 1.6e-22 80.0 0.0 1.9e-22 79.7 0.0 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Ank_2 PF12796.5 001025078.2_22424001_1 - 9.1e-40 135.0 1.8 4.9e-15 55.8 0.2 3.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001025078.2_22424001_1 - 1.9e-23 82.0 0.9 1.8e-10 40.7 0.0 4.9 2 2 3 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.28 001025078.2_22424001_1 - 2.4e-22 78.2 0.4 4.7e-06 26.7 0.0 5.5 5 1 1 6 6 6 4 Ankyrin repeat Ank_4 PF13637.4 001025078.2_22424001_1 - 1.1e-21 76.8 0.3 7.7e-11 42.2 0.0 4.0 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 001025078.2_22424001_1 - 1.6e-20 70.9 0.4 0.00024 21.2 0.0 6.0 6 0 0 6 6 6 4 Ankyrin repeat SAM_2 PF07647.15 001025078.2_22424001_1 - 1.8e-07 31.0 0.2 3.9e-07 29.9 0.2 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 001025078.2_22424001_1 - 2.6e-06 27.6 0.4 5.9e-06 26.5 0.4 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) IL4 PF00727.16 001043339.1_22422001_1 - 8.5e-49 164.2 7.8 1.2e-48 163.8 7.8 1.2 1 0 0 1 1 1 1 Interleukin 4 Ank_2 PF12796.5 001195309.2_39523001_1 - 5.1e-33 113.4 1.3 4.3e-15 55.9 0.2 4.0 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001195309.2_39523001_1 - 3.2e-24 84.5 0.2 1.8e-10 40.8 0.0 5.1 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 001195309.2_39523001_1 - 4.2e-24 84.4 0.3 5e-11 42.8 0.0 4.0 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.28 001195309.2_39523001_1 - 7.7e-22 76.6 0.5 3.2e-06 27.2 0.0 5.9 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.4 001195309.2_39523001_1 - 6.2e-21 72.1 0.1 0.00086 19.5 0.0 6.1 6 0 0 6 6 6 4 Ankyrin repeat SAM_2 PF07647.15 001195309.2_39523001_1 - 9.2e-10 38.4 0.2 3.4e-09 36.6 0.2 2.1 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 001195309.2_39523001_1 - 2.5e-07 30.9 0.5 6.3e-07 29.6 0.5 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DNA_repr_REX1B PF14966.4 001195309.2_39523001_1 - 0.02 15.4 0.2 2.4 8.7 0.0 2.7 2 0 0 2 2 2 0 DNA repair REX1-B Integrin_beta PF00362.16 001113770.1_39525001_1 - 1.6e-114 381.6 0.0 2.2e-114 381.2 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.9 001113770.1_39525001_1 - 3.8e-23 80.8 0.4 6.9e-23 79.9 0.4 1.5 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.10 001113770.1_39525001_1 - 4.9e-22 78.1 9.8 4.9e-22 78.1 9.8 4.5 5 1 1 6 6 6 1 Integrin beta tail domain PSI_integrin PF17205.1 001113770.1_39525001_1 - 3.8e-12 45.7 8.3 3.8e-12 45.7 8.3 4.8 4 1 0 4 4 4 1 Integrin plexin domain EGF_2 PF07974.11 001113770.1_39525001_1 - 1e-08 35.2 58.6 2.4e-06 27.7 13.7 7.3 7 1 1 8 8 8 3 EGF-like domain 7tm_1 PF00001.19 001082058.2_37923001_2 - 9.6e-50 169.2 25.0 1.5e-49 168.6 25.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001082058.2_37923001_2 - 7.3e-11 42.2 20.0 1.9e-10 40.9 20.0 1.6 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001082058.2_37923001_2 - 1.3e-08 34.4 25.6 2.5e-08 33.5 25.6 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx UPF0182 PF03699.11 001082058.2_37923001_2 - 3.2 5.6 15.6 4.5 5.1 15.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) Aldo_ket_red PF00248.19 001081997.1_37922001_1 - 4.4e-47 160.5 0.0 7.1e-47 159.8 0.0 1.3 1 1 0 1 1 1 1 Aldo/keto reductase family Claudin_2 PF13903.4 001082393.1_37923001_1 - 3e-39 134.7 4.1 4e-39 134.2 4.1 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.18 001082393.1_37923001_1 - 1.1e-11 44.8 12.1 1.9e-10 40.7 12.1 2.0 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family DUF1049 PF06305.9 001082393.1_37923001_1 - 0.0002 21.0 0.5 0.048 13.4 0.1 3.1 3 0 0 3 3 3 1 Protein of unknown function (DUF1049) UL45 PF05473.10 001082393.1_37923001_1 - 0.056 12.9 1.0 0.14 11.6 0.2 1.9 2 0 0 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like Clc-like PF07062.10 001082393.1_37923001_1 - 0.079 12.3 4.2 0.2 11.0 4.2 1.6 1 1 0 1 1 1 0 Clc-like Acyl_transf_3 PF01757.20 001082393.1_37923001_1 - 0.61 9.0 6.5 0.39 9.6 4.2 1.6 2 0 0 2 2 2 0 Acyltransferase family Claudin_3 PF06653.9 001082393.1_37923001_1 - 6.4 6.6 10.4 44 3.8 10.4 2.0 1 1 0 1 1 1 0 Tight junction protein, Claudin-like DUF4937 PF16291.3 001082393.1_37923001_2 - 0.26 11.4 0.7 0.53 10.4 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4937 Dynein_light PF01221.16 001082018.2_37922001_3 - 1.9e-42 143.3 1.9 2.4e-42 143.0 1.9 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 Ribosomal_S18 PF01084.18 001105165.1_29622001_1 - 1.2e-15 57.3 0.1 1.2e-15 57.3 0.1 1.6 2 0 0 2 2 2 1 Ribosomal protein S18 HTH_21 PF13276.4 001105165.1_29622001_1 - 0.064 13.3 0.2 0.19 11.7 0.2 1.8 1 0 0 1 1 1 0 HTH-like domain zf-RING_10 PF16685.3 001105165.1_29622001_1 - 0.11 12.5 0.7 0.68 10.0 0.2 2.1 2 0 0 2 2 2 0 zinc RING finger of MSL2 RecR PF02132.13 001105165.1_29622001_1 - 0.29 10.6 2.1 2.5 7.6 0.5 2.3 2 0 0 2 2 2 0 RecR protein Lipase_GDSL PF00657.20 001077185.1_32329001_1 - 7.2e-76 254.5 0.0 1.7e-25 90.0 0.0 4.7 4 1 0 4 4 4 3 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.4 001077185.1_32329001_1 - 2.6e-23 83.2 5.0 7.4e-07 29.6 0.1 5.6 3 3 0 3 3 3 3 GDSL-like Lipase/Acylhydrolase family DUF2179 PF10035.7 001077185.1_32329001_1 - 0.055 13.1 0.0 4 7.1 0.0 2.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2179) SDF PF00375.16 001082249.1_37927001_3 - 1.3e-133 445.7 29.2 1.6e-133 445.4 29.2 1.1 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family CUB PF00431.18 001082311.1_37923001_1 - 5.1e-35 120.0 0.0 7.5e-35 119.5 0.0 1.3 1 0 0 1 1 1 1 CUB domain Xlink PF00193.15 001082311.1_37923001_1 - 1.5e-29 102.1 0.1 2.3e-29 101.5 0.1 1.3 1 0 0 1 1 1 1 Extracellular link domain V-set PF07686.15 001082359.1_37922001_1 - 4.3e-16 58.9 0.4 5.4e-16 58.6 0.4 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain 7TM_GPCR_Srw PF10324.7 001082359.1_37922001_1 - 0.008 15.4 0.6 0.011 14.9 0.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw Ig_2 PF13895.4 001082359.1_37922001_1 - 0.032 14.5 0.0 0.06 13.6 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain Ig_3 PF13927.4 001082359.1_37922001_1 - 0.037 14.5 0.3 0.068 13.6 0.3 1.6 1 1 0 1 1 1 0 Immunoglobulin domain ig PF00047.23 001082359.1_37922001_1 - 0.087 12.9 1.2 0.18 11.8 1.2 1.7 1 1 0 1 1 1 0 Immunoglobulin domain ADH_N PF08240.10 001101704.1_37923001_3 - 1.3e-25 89.3 0.7 2.9e-25 88.1 0.7 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.24 001101704.1_37923001_3 - 4.3e-23 81.5 0.1 7.7e-23 80.7 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.4 001101704.1_37923001_3 - 0.00011 23.1 0.0 0.00017 22.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.3 001101704.1_37923001_3 - 0.00019 20.9 0.0 0.00031 20.2 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus UDPG_MGDP_dh_N PF03721.12 001101704.1_37923001_3 - 0.014 14.8 0.1 0.026 14.0 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.17 001101704.1_37923001_3 - 0.041 13.1 0.1 0.066 12.4 0.1 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NUC202 PF08166.10 001040149.1_29627001_1 - 2.4e-45 152.3 11.3 6.3e-26 90.1 0.1 3.2 3 0 0 3 3 3 2 NUC202 domain RIX1 PF08167.10 001040149.1_29627001_1 - 6.1e-26 91.2 0.1 1.7e-25 89.8 0.1 1.7 1 0 0 1 1 1 1 rRNA processing/ribosome biogenesis Ldh_1_N PF00056.21 001082277.1_37924001_3 - 2.8e-50 169.9 0.4 4e-50 169.5 0.4 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 001082277.1_37924001_3 - 1.4e-24 86.7 0.0 2.7e-24 85.8 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Pyr_redox_2 PF07992.12 001082277.1_37924001_3 - 0.022 13.9 0.0 0.038 13.1 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Glyco_hydro_4 PF02056.14 001082277.1_37924001_3 - 0.053 12.9 0.4 0.21 11.0 0.0 2.0 2 0 0 2 2 2 0 Family 4 glycosyl hydrolase Peptidase_C1 PF00112.21 001082641.1_37924001_1 - 3.1e-82 275.8 5.1 4e-82 275.4 5.1 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 001082641.1_37924001_1 - 5.4e-11 42.6 0.2 9.3e-11 41.9 0.2 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 001082641.1_37924001_1 - 1.4e-07 30.5 1.5 0.00017 20.4 0.7 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Cytochrom_B561 PF03188.14 001093790.1_39522001_1 - 3.8e-45 153.3 9.4 8e-45 152.2 9.4 1.6 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 GPI2 PF06432.9 001093790.1_39522001_1 - 0.19 11.0 6.0 3 7.1 1.2 2.3 1 1 1 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase DUF4134 PF13572.4 001093790.1_39522001_1 - 1.4 9.1 5.8 4.8 7.4 0.2 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4134) PIG-F PF06699.9 001093790.1_39522001_1 - 2.2 8.3 9.6 1.2 9.1 0.4 3.0 1 1 1 2 2 2 0 GPI biosynthesis protein family Pig-F DUF4079 PF13301.4 001093790.1_39522001_1 - 3.5 7.6 15.8 4 7.5 12.6 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF4079) Cation_ATPase_C PF00689.19 001093790.1_39522001_1 - 3.7 7.1 9.5 0.59 9.7 4.3 2.0 1 1 1 2 2 2 0 Cation transporting ATPase, C-terminus Claudin_3 PF06653.9 001093790.1_39522001_1 - 7.9 6.3 9.4 23 4.8 0.7 2.8 1 1 2 3 3 3 0 Tight junction protein, Claudin-like DUF4759 PF15954.3 001093790.1_39522001_3 - 0.012 15.5 0.6 0.012 15.5 0.6 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4759) RYDR_ITPR PF01365.19 001082762.1_37929001_1 - 1.4e-134 445.8 13.7 2.2e-73 245.9 0.0 4.2 4 0 0 4 4 4 2 RIH domain RyR PF02026.14 001082762.1_37929001_1 - 5.4e-124 404.6 2.2 1.4e-33 114.7 0.0 5.2 4 0 0 4 4 4 4 RyR domain RR_TM4-6 PF06459.10 001082762.1_37929001_1 - 1.2e-98 330.2 0.9 1.2e-98 330.2 0.9 3.5 4 0 0 4 4 3 1 Ryanodine Receptor TM 4-6 SPRY PF00622.26 001082762.1_37929001_1 - 5.1e-60 200.7 0.0 2.7e-19 69.3 0.0 3.8 3 0 0 3 3 3 3 SPRY domain Ins145_P3_rec PF08709.9 001082762.1_37929001_1 - 8.8e-59 198.1 0.0 3.7e-56 189.6 0.0 3.4 2 1 1 3 3 3 1 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.17 001082762.1_37929001_1 - 2.7e-58 196.7 3.8 1.4e-54 184.6 0.0 2.9 3 0 0 3 3 3 2 MIR domain RIH_assoc PF08454.9 001082762.1_37929001_1 - 4.8e-30 103.3 0.2 4.8e-30 103.3 0.2 4.7 4 1 0 4 4 4 1 RyR and IP3R Homology associated Ion_trans PF00520.29 001082762.1_37929001_1 - 1.2e-13 50.8 3.4 1.2e-13 50.8 3.4 3.5 5 0 0 5 5 5 1 Ion transport protein EF-hand_1 PF00036.30 001082762.1_37929001_1 - 5.6e-05 22.3 0.1 0.00026 20.2 0.1 2.3 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.4 001082762.1_37929001_1 - 0.00018 21.1 0.5 0.00079 19.0 0.5 2.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 001082762.1_37929001_1 - 0.00076 19.1 0.0 0.005 16.6 0.0 2.4 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.4 001082762.1_37929001_1 - 0.0054 17.0 1.1 0.037 14.4 1.1 2.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.4 001082762.1_37929001_1 - 0.04 13.3 0.2 0.13 11.7 0.0 2.0 2 0 0 2 2 2 0 EF hand GWT1 PF06423.10 001082762.1_37929001_1 - 9 6.3 7.3 2.4 8.2 0.0 3.2 4 0 0 4 4 2 0 GWT1 IL8 PF00048.18 001082196.1_37922001_3 - 1e-21 76.7 0.3 1.4e-21 76.3 0.3 1.2 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Annexin PF00191.18 001098542.1_39724001_2 - 1.3e-94 310.2 15.1 4.7e-25 87.3 0.2 4.2 4 0 0 4 4 4 4 Annexin Myb_DNA-bind_7 PF15963.3 001098542.1_39724001_2 - 0.0061 16.3 0.2 19 5.1 0.0 3.5 3 0 0 3 3 3 2 Myb DNA-binding like DUF3500 PF12006.6 001098542.1_39724001_2 - 0.036 13.4 0.1 0.053 12.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3500) TINF2_N PF14973.4 001098542.1_39724001_2 - 0.13 12.4 1.3 18 5.5 0.0 3.3 3 1 1 4 4 4 0 TERF1-interacting nuclear factor 2 N-terminus Caveolin PF01146.15 001168694.1_22427001_3 - 9.3e-55 184.1 0.8 1.5e-54 183.4 0.8 1.3 1 0 0 1 1 1 1 Caveolin IFN-gamma PF00714.15 001112640.1_40421001_1 - 2.4e-66 221.7 3.1 3.1e-66 221.3 3.1 1.0 1 0 0 1 1 1 1 Interferon gamma CEP63 PF17045.3 001112640.1_40421001_1 - 0.024 14.4 1.6 0.03 14.1 1.6 1.1 1 0 0 1 1 1 0 Centrosomal protein of 63 kDa EF-hand_1 PF00036.30 001077224.1_49822001_1 - 2.4e-28 95.4 7.3 3.4e-06 26.1 0.0 6.4 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.4 001077224.1_49822001_1 - 9.2e-25 84.3 11.9 0.0001 21.8 0.1 6.3 6 0 0 6 6 6 6 EF-hand domain EF-hand_7 PF13499.4 001077224.1_49822001_1 - 6.4e-18 64.9 10.3 6.7e-09 36.0 0.4 4.0 3 2 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 001077224.1_49822001_1 - 8e-18 62.9 1.0 0.01 15.2 0.2 5.6 5 0 0 5 5 5 5 EF hand EF-hand_10 PF14788.4 001077224.1_49822001_1 - 1.7e-07 30.9 3.5 0.045 13.5 0.0 5.3 6 0 0 6 6 6 1 EF hand GPHH PF16905.3 001077224.1_49822001_1 - 2.8e-07 30.1 0.4 0.004 16.8 0.0 3.0 3 1 0 3 3 3 2 Voltage-dependent L-type calcium channel, IQ-associated EF-hand_8 PF13833.4 001077224.1_49822001_1 - 5.8e-06 25.8 5.2 0.043 13.5 0.3 4.6 4 1 1 5 5 5 1 EF-hand domain pair SPARC_Ca_bdg PF10591.7 001077224.1_49822001_1 - 0.00053 20.2 8.1 0.23 11.6 0.1 4.6 2 2 2 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.11 001077224.1_49822001_1 - 0.0013 18.5 4.0 0.92 9.3 0.0 4.1 2 2 2 4 4 4 1 Caleosin related protein Nt_Gln_amidase PF09764.7 001077224.1_49822001_1 - 0.0027 17.2 0.2 0.0063 16.0 0.1 1.6 2 0 0 2 2 2 1 N-terminal glutamine amidase Asp PF00026.21 001082634.1_37923001_3 - 8.2e-115 383.4 2.9 9.6e-115 383.2 2.9 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001082634.1_37923001_3 - 4e-20 72.7 7.5 1.3e-18 67.8 4.9 2.6 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001082634.1_37923001_3 - 5.5e-13 48.3 1.6 8.5e-13 47.8 1.6 1.3 1 0 0 1 1 1 1 A1 Propeptide TAXi_C PF14541.4 001082634.1_37923001_3 - 2e-05 24.3 0.0 6.9e-05 22.5 0.0 2.0 2 1 0 2 2 2 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.4 001082634.1_37923001_3 - 0.0035 17.8 0.0 6.6 7.4 0.0 3.0 2 1 0 2 2 2 2 Aspartyl protease KH_1 PF00013.27 001082124.1_37923001_1 - 1.9e-51 171.6 14.5 1e-17 63.5 0.9 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.15 001082124.1_37923001_1 - 2e-15 56.2 5.4 0.00042 19.9 0.0 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.4 001082124.1_37923001_1 - 2.1e-07 30.6 3.3 0.047 13.4 0.2 3.4 3 0 0 3 3 3 3 KH domain KH_5 PF13184.4 001082124.1_37923001_1 - 0.00031 20.6 8.8 1 9.4 0.2 3.4 3 0 0 3 3 3 3 NusA-like KH domain Bac_chlorC PF02043.15 001082124.1_37923001_1 - 0.045 13.6 0.0 0.14 12.0 0.0 1.8 1 0 0 1 1 1 0 Bacteriochlorophyll C binding protein MOEP19 PF16005.3 001082124.1_37923001_1 - 0.17 11.8 0.0 1.7 8.6 0.0 2.4 3 0 0 3 3 3 0 KH-like RNA-binding domain Ig_5 PF16681.3 001082001.1_37922001_2 - 1.4e-33 115.1 0.4 2.2e-33 114.4 0.4 1.3 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 001082001.1_37922001_2 - 4.1e-17 62.2 0.4 6.1e-17 61.6 0.4 1.3 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 delta chain ITAM PF02189.13 001082001.1_37922001_2 - 2.1e-05 24.5 0.4 3.8e-05 23.8 0.4 1.4 1 0 0 1 1 1 1 Immunoreceptor tyrosine-based activation motif Ig_2 PF13895.4 001082001.1_37922001_2 - 0.00031 20.9 0.0 0.00062 19.9 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 001082001.1_37922001_2 - 0.005 17.3 0.1 0.013 15.9 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001082001.1_37922001_2 - 0.0087 16.1 1.2 0.13 12.4 1.2 2.3 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 001082001.1_37922001_2 - 0.016 15.2 1.7 2.2 8.3 0.2 2.5 2 1 1 3 3 3 0 Immunoglobulin V-set domain Nebulin PF00880.16 001082778.1_37927001_3 - 6.6e-21 73.7 4.1 8.4e-10 38.3 0.3 2.4 2 0 0 2 2 2 2 Nebulin repeat SH3_9 PF14604.4 001082778.1_37927001_3 - 6e-14 51.5 0.1 1.2e-13 50.6 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain LIM PF00412.20 001082778.1_37927001_3 - 9.8e-12 44.8 11.5 1.8e-11 44.0 11.5 1.4 1 0 0 1 1 1 1 LIM domain SH3_1 PF00018.26 001082778.1_37927001_3 - 6.8e-11 41.5 0.1 1.1e-10 40.8 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 001082778.1_37927001_3 - 6.2e-08 32.1 0.0 1.2e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain zf-C2HC5 PF06221.11 001082778.1_37927001_3 - 0.26 11.2 4.2 0.94 9.4 4.2 2.0 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type EF-hand_1 PF00036.30 001082734.1_37922001_1 - 9.8e-18 62.2 25.1 4.1e-05 22.7 0.5 7.5 7 0 0 7 7 7 6 EF hand EF-hand_7 PF13499.4 001082734.1_37922001_1 - 5.9e-17 61.8 25.0 1.2e-05 25.6 3.1 4.4 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.4 001082734.1_37922001_1 - 1.5e-15 55.6 20.5 0.0039 16.9 0.2 7.3 7 0 0 7 7 7 6 EF-hand domain EF-hand_5 PF13202.4 001082734.1_37922001_1 - 2e-12 45.9 35.7 0.0001 21.5 0.8 7.4 8 0 0 8 8 8 6 EF hand EF-hand_8 PF13833.4 001082734.1_37922001_1 - 2.8e-08 33.2 14.1 0.00078 19.0 0.0 5.2 5 1 0 5 5 5 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 001082734.1_37922001_1 - 0.15 12.3 15.4 2.7 8.2 0.8 4.1 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Gln-synt_C PF00120.22 001082227.1_37924001_3 - 3.4e-80 269.5 0.0 4.7e-80 269.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.17 001082227.1_37924001_3 - 1.3e-05 24.7 0.5 8e-05 22.2 0.1 2.3 2 0 0 2 2 2 1 Glutamine synthetase, beta-Grasp domain Gln-synt_N_2 PF16952.3 001082227.1_37924001_3 - 3.3e-05 23.5 0.0 6.5e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Glutamine synthetase N-terminal domain RRM_1 PF00076.20 001082038.1_37924001_1 - 6e-13 48.3 0.1 1.2e-12 47.4 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 001082038.1_37924001_1 - 0.074 12.5 0.1 0.16 11.4 0.1 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) APG6 PF04111.10 001082038.1_37924001_1 - 0.34 10.1 7.2 0.48 9.6 7.2 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 RP-C_C PF11800.6 001082038.1_37924001_1 - 0.41 10.5 5.0 0.65 9.9 5.0 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region Nup88 PF10168.7 001082038.1_37924001_1 - 1.2 6.7 7.1 1.8 6.2 7.1 1.1 1 0 0 1 1 1 0 Nuclear pore component XhlA PF10779.7 001082038.1_37924001_1 - 1.5 8.9 5.0 3.1 7.9 5.0 1.6 1 0 0 1 1 1 0 Haemolysin XhlA BNR_2 PF13088.4 001101822.1_49824001_1 - 2.8e-48 164.5 0.0 3.7e-48 164.1 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.4 001101822.1_49824001_1 - 3.5e-13 49.4 0.0 5.6e-13 48.7 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.18 001101822.1_49824001_1 - 0.0039 16.9 15.4 4.6 7.5 0.0 4.9 4 0 0 4 4 4 3 BNR/Asp-box repeat COX8 PF02285.13 001112641.1_40421001_3 - 1.7e-22 78.9 0.1 3.4e-22 77.9 0.1 1.6 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIII Tme5_EGF_like PF09064.8 001112641.1_40421001_3 - 0.13 12.0 1.7 0.49 10.2 1.7 1.8 2 0 0 2 2 2 0 Thrombomodulin like fifth domain, EGF-like Insulin PF00049.16 001082335.1_37921001_2 - 5.7e-25 88.0 1.4 9.4e-25 87.3 1.4 1.3 1 0 0 1 1 1 1 Insulin/IGF/Relaxin family Ins_beta PF03488.12 001082335.1_37921001_2 - 0.092 12.6 5.6 0.63 10.0 0.2 2.3 2 0 0 2 2 2 0 Nematode insulin-related peptide beta type Serine_rich PF08824.8 001110431.2_49826001_2 - 1.8e-61 206.6 1.5 2.8e-61 206.0 1.5 1.3 1 0 0 1 1 1 1 Serine rich protein interaction domain DUF3513 PF12026.6 001110431.2_49826001_2 - 1.5e-59 201.1 0.0 3.2e-59 200.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3513) SH3_9 PF14604.4 001110431.2_49826001_2 - 6.4e-12 45.0 0.0 1.1e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001110431.2_49826001_2 - 2.5e-09 36.4 0.0 4.9e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.15 001110431.2_49826001_2 - 1.1e-07 31.3 0.0 2.1e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Filament PF00038.19 001110431.2_49826001_2 - 0.051 13.0 0.2 0.095 12.1 0.2 1.4 1 0 0 1 1 1 0 Intermediate filament protein LXG PF04740.10 001110431.2_49826001_2 - 0.16 11.5 1.6 0.14 11.7 0.2 1.5 2 0 0 2 2 2 0 LXG domain of WXG superfamily An_peroxidase PF03098.13 001082681.1_37925001_2 - 2.1e-49 168.4 0.0 9.4e-43 146.4 0.0 2.4 1 1 1 2 2 2 2 Animal haem peroxidase EGF PF00008.25 001082681.1_37925001_2 - 0.00014 22.0 9.0 0.00014 22.0 9.0 2.0 2 0 0 2 2 2 1 EGF-like domain Cadherin_tail PF15974.3 001082681.1_37925001_2 - 1 9.6 7.8 1.6 8.9 7.8 1.3 1 0 0 1 1 1 0 Cadherin C-terminal cytoplasmic tail, catenin-binding region EGF_2 PF07974.11 001082681.1_37925001_2 - 1.3 9.3 12.0 0.36 11.1 8.6 1.8 2 0 0 2 2 2 0 EGF-like domain Filament PF00038.19 001098563.1_39724001_2 - 1.8e-98 329.9 16.1 2.4e-98 329.4 16.1 1.2 1 0 0 1 1 1 1 Intermediate filament protein Phage_Mu_Gam PF07352.10 001098563.1_39724001_2 - 0.0097 15.7 15.5 0.013 15.2 0.3 3.7 3 1 0 4 4 4 2 Bacteriophage Mu Gam like protein TPR_MLP1_2 PF07926.10 001098563.1_39724001_2 - 0.21 11.5 32.8 0.038 13.9 1.4 3.8 4 1 0 4 4 4 0 TPR/MLP1/MLP2-like protein Reo_sigmaC PF04582.10 001098563.1_39724001_2 - 1.5 8.1 8.8 0.28 10.4 2.9 2.3 2 1 0 3 3 3 0 Reovirus sigma C capsid protein Allexi_40kDa PF05549.9 001098563.1_39724001_2 - 2 7.7 6.8 0.37 10.1 2.4 2.0 2 0 0 2 2 2 0 Allexivirus 40kDa protein Atg14 PF10186.7 001098563.1_39724001_2 - 2 7.3 10.2 1.2 8.0 4.0 2.5 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF724 PF05266.12 001098563.1_39724001_2 - 2.5 7.8 8.5 1.4 8.5 4.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF724) V_ATPase_I PF01496.17 001098563.1_39724001_2 - 4.3 5.0 9.4 0.49 8.1 4.5 1.7 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Bacillus_HBL PF05791.9 001098563.1_39724001_2 - 7 6.2 10.6 0.18 11.4 2.7 2.4 3 0 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) FlxA PF14282.4 001098563.1_39724001_2 - 9.2 6.2 19.3 0.093 12.6 7.0 3.2 2 1 1 3 3 3 0 FlxA-like protein p450 PF00067.20 001082622.1_37925001_3 - 7.3e-52 176.5 0.0 1.1e-51 175.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 EF-hand_6 PF13405.4 001082264.1_37923001_3 - 7.3e-12 44.1 0.0 0.023 14.5 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.30 001082264.1_37923001_3 - 8.4e-12 43.6 0.2 0.011 15.1 0.0 4.5 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.4 001082264.1_37923001_3 - 2.2e-07 30.4 1.6 1.8e-06 27.5 0.2 2.9 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_7 PF13499.4 001082264.1_37923001_3 - 3.4e-07 30.5 1.2 0.77 10.1 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.4 001082264.1_37923001_3 - 2.3e-06 26.7 0.0 0.27 10.7 0.0 3.9 3 0 0 3 3 3 2 EF hand PMP22_Claudin PF00822.18 001105239.1_39727001_1 - 2.6e-54 183.4 13.5 3.9e-54 182.8 13.5 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001105239.1_39727001_1 - 2.6e-08 33.7 13.0 7.5e-08 32.2 11.8 2.2 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Amastin PF07344.9 001105239.1_39727001_1 - 0.039 13.7 10.5 0.072 12.8 10.1 1.7 1 1 0 1 1 1 0 Amastin surface glycoprotein Mem_trans PF03547.16 001105239.1_39727001_1 - 0.13 10.5 1.8 0.21 9.8 1.8 1.2 1 0 0 1 1 1 0 Membrane transport protein Clc-like PF07062.10 001105239.1_39727001_1 - 3.4 6.9 13.5 0.42 9.9 7.5 2.0 1 1 1 2 2 2 0 Clc-like Guanylate_kin PF00625.19 001082279.1_37924001_3 - 7.5e-50 169.0 1.2 8.6e-50 168.8 0.3 1.6 2 0 0 2 2 2 1 Guanylate kinase VGCC_beta4Aa_N PF12052.6 001082279.1_37924001_3 - 1.7e-22 79.1 6.2 5.1e-22 77.6 6.2 1.9 1 0 0 1 1 1 1 Voltage gated calcium channel subunit beta domain 4Aa N terminal SH3_1 PF00018.26 001082279.1_37924001_3 - 0.00084 18.8 0.1 0.0033 16.9 0.1 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.4 001082279.1_37924001_3 - 0.06 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain SH3_2 PF07653.15 001082279.1_37924001_3 - 0.16 11.6 0.1 0.16 11.6 0.1 2.2 3 0 0 3 3 3 0 Variant SH3 domain ITI_HC_C PF06668.10 001082008.1_37926001_3 - 5.1e-73 244.6 0.2 8.9e-73 243.8 0.2 1.4 1 0 0 1 1 1 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus VIT PF08487.8 001082008.1_37926001_3 - 1.9e-33 114.9 3.0 4.4e-33 113.7 3.0 1.7 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA PF00092.26 001082008.1_37926001_3 - 2e-26 93.2 0.1 3.5e-26 92.4 0.1 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.4 001082008.1_37926001_3 - 7.9e-17 61.4 0.0 1.3e-16 60.7 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.4 001082008.1_37926001_3 - 3.2e-15 56.6 0.1 7.8e-15 55.3 0.1 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.12 001082008.1_37926001_3 - 1.5e-05 24.4 0.0 2.3e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein vWA-TerF-like PF10138.7 001082008.1_37926001_3 - 2.3e-05 24.5 0.0 3.9e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus Glyco_hydro_61 PF03443.12 001082008.1_37926001_3 - 0.00071 19.4 0.0 0.0016 18.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 DUF2201 PF09967.7 001082008.1_37926001_3 - 0.0032 17.5 0.0 0.025 14.6 0.0 2.4 1 1 0 1 1 1 1 VWA-like domain (DUF2201) wnt PF00110.17 001171042.1_37925001_2 - 2.4e-121 404.9 23.6 3e-121 404.5 23.6 1.1 1 0 0 1 1 1 1 wnt family ACBP PF00887.17 001082113.1_37922001_3 - 5.7e-30 103.2 2.2 7.2e-30 102.9 2.2 1.1 1 0 0 1 1 1 1 Acyl CoA binding protein 7tm_2 PF00002.22 001014394.2_32927001_3 - 3.4e-28 98.5 15.4 5.2e-28 97.9 15.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.19 001014394.2_32927001_3 - 2.5e-13 50.3 3.4 2.5e-13 50.3 3.4 2.5 3 0 0 3 3 3 1 GPCR proteolysis site, GPS, motif HRM PF02793.20 001014394.2_32927001_3 - 0.00028 21.0 1.9 0.00028 21.0 1.9 2.0 2 0 0 2 2 2 1 Hormone receptor domain GAIN PF16489.3 001014394.2_32927001_3 - 0.0044 16.3 0.2 0.0066 15.7 0.2 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain cEGF PF12662.5 001014394.2_32927001_3 - 0.25 11.2 3.4 0.33 10.8 1.0 2.5 2 0 0 2 2 2 0 Complement Clr-like EGF-like S_100 PF01023.17 001082730.1_37921001_1 - 9e-22 76.4 0.9 1.6e-21 75.6 0.9 1.4 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.30 001082730.1_37921001_1 - 3.7e-06 26.0 0.8 3.7e-06 26.0 0.8 2.3 3 1 0 3 3 3 1 EF hand EF-hand_7 PF13499.4 001082730.1_37921001_1 - 4.7e-06 26.8 1.8 7.4e-06 26.2 1.7 1.4 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 001082730.1_37921001_1 - 0.00032 20.3 0.6 0.011 15.4 0.1 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_4 PF12763.5 001082730.1_37921001_1 - 0.0034 17.2 0.1 0.0038 17.0 0.1 1.2 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.4 001082730.1_37921001_1 - 0.0088 15.4 2.0 0.017 14.5 0.4 2.3 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.4 001082730.1_37921001_1 - 0.0091 15.6 1.4 0.017 14.8 1.4 1.5 1 0 0 1 1 1 1 EF-hand domain pair Sfi1 PF08457.8 001169036.1_40428001_1 - 0.00042 18.8 24.0 0.00042 18.8 24.0 6.7 1 1 4 6 6 6 5 Sfi1 spindle body protein IKI3 PF04762.10 001082655.1_37929001_1 - 0 1050.4 0.0 0 1050.1 0.0 1.1 1 0 0 1 1 1 1 IKI3 family ANAPC4_WD40 PF12894.5 001082655.1_37929001_1 - 0.00072 19.7 0.8 12 6.2 0.0 5.0 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Guanylate_kin PF00625.19 001168810.1_40423001_1 - 8.8e-66 220.9 0.2 1.5e-65 220.1 0.2 1.4 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.22 001168810.1_40423001_1 - 8e-20 70.9 1.3 8e-20 70.9 1.3 1.9 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) SH3_2 PF07653.15 001168810.1_40423001_1 - 2.6e-10 39.7 0.0 5.8e-10 38.6 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001168810.1_40423001_1 - 1.2e-08 34.2 0.9 5.8e-08 32.1 0.9 2.1 1 1 0 1 1 1 1 SH3 domain PDZ_2 PF13180.4 001168810.1_40423001_1 - 2.3e-05 24.5 0.2 0.00013 22.1 0.0 2.2 2 0 0 2 2 2 1 PDZ domain SH3_9 PF14604.4 001168810.1_40423001_1 - 0.00016 21.3 0.0 0.00037 20.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain DUF258 PF03193.14 001168810.1_40423001_1 - 0.001 18.9 0.0 0.0071 16.1 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 001168810.1_40423001_1 - 0.013 15.4 0.0 0.042 13.8 0.0 2.0 2 1 0 2 2 2 0 50S ribosome-binding GTPase P33MONOX PF15302.4 001168810.1_40423001_1 - 0.031 13.8 0.1 0.056 13.0 0.1 1.3 1 0 0 1 1 1 0 P33 mono-oxygenase AAA_22 PF13401.4 001168810.1_40423001_1 - 0.048 13.8 0.0 0.32 11.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain Antimicrobial_5 PF08026.9 001009108.2_39722001_1 - 1.2 9.1 5.1 7.9 6.4 0.1 2.7 2 0 0 2 2 2 0 Bee antimicrobial peptide RnaseA PF00074.18 001009108.2_39722001_2 - 1e-43 148.6 10.4 1.2e-43 148.4 10.4 1.1 1 0 0 1 1 1 1 Pancreatic ribonuclease Mesothelin PF06060.10 001009108.2_39722001_2 - 0.045 11.9 0.1 0.056 11.6 0.1 1.0 1 0 0 1 1 1 0 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) Ank_2 PF12796.5 001171019.1_37924001_2 - 3.1e-33 114.1 0.6 4.3e-15 55.9 0.1 4.0 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001171019.1_37924001_2 - 3e-24 84.6 0.4 1.4e-10 41.1 0.0 5.2 3 2 3 6 6 6 3 Ankyrin repeats (many copies) Ank PF00023.28 001171019.1_37924001_2 - 7.7e-24 82.9 0.2 1e-06 28.8 0.0 6.1 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.4 001171019.1_37924001_2 - 1.1e-22 79.9 0.3 6.9e-11 42.3 0.0 4.1 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 001171019.1_37924001_2 - 2.9e-21 73.1 0.0 9.9e-05 22.3 0.0 5.9 6 0 0 6 6 6 4 Ankyrin repeat SAM_2 PF07647.15 001171019.1_37924001_2 - 1.6e-07 31.2 0.3 3.3e-07 30.2 0.3 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.28 001171019.1_37924001_2 - 6.2e-06 26.4 0.5 1.3e-05 25.4 0.5 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Trypsin PF00089.24 001082011.1_37925001_2 - 2.6e-67 226.8 0.2 3.6e-67 226.3 0.2 1.2 1 0 0 1 1 1 1 Trypsin Kringle PF00051.16 001082011.1_37925001_2 - 1.3e-21 76.6 3.2 2.7e-21 75.5 3.2 1.6 1 0 0 1 1 1 1 Kringle domain DUF316 PF03761.13 001082011.1_37925001_2 - 0.00012 21.6 0.0 0.32 10.4 0.0 2.1 2 0 0 2 2 2 2 Chymotrypsin family Peptidase-S1 Trypsin_2 PF13365.4 001082011.1_37925001_2 - 0.023 15.5 0.0 0.04 14.7 0.0 1.3 1 0 0 1 1 1 0 Trypsin-like peptidase domain EGF PF00008.25 001082011.1_37925001_2 - 0.22 11.7 10.9 0.14 12.3 6.8 3.0 2 0 0 2 2 2 0 EGF-like domain Integrin_beta PF00362.16 001048160.2_22426001_3 - 1.1e-114 382.1 0.0 1.6e-114 381.6 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.9 001048160.2_22426001_3 - 4.1e-22 77.5 0.4 7.4e-22 76.6 0.4 1.5 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.10 001048160.2_22426001_3 - 4.3e-22 78.3 9.2 4.3e-22 78.3 9.2 4.3 5 1 0 5 5 5 1 Integrin beta tail domain PSI_integrin PF17205.1 001048160.2_22426001_3 - 1.1e-11 44.3 7.3 1.1e-11 44.3 7.3 4.9 4 1 1 5 5 5 1 Integrin plexin domain EGF_2 PF07974.11 001048160.2_22426001_3 - 3.5e-08 33.5 59.2 6.4e-06 26.3 14.3 7.2 7 1 0 7 7 7 3 EGF-like domain SP_C-Propep PF08999.8 001044533.1_49822001_2 - 5.9e-51 170.0 3.7 8.8e-51 169.5 3.7 1.3 1 0 0 1 1 1 1 Surfactant protein C, N terminal propeptide BRICHOS PF04089.12 001044533.1_49822001_2 - 1.9e-23 82.2 0.0 2.8e-23 81.7 0.0 1.3 1 0 0 1 1 1 1 BRICHOS domain PTPS_related PF10131.7 001044533.1_49822001_2 - 0.019 13.2 0.0 0.026 12.7 0.0 1.1 1 0 0 1 1 1 0 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein DUF945 PF06097.9 001044533.1_49822001_2 - 0.12 11.3 0.5 0.2 10.6 0.5 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF945) zf-DHHC PF01529.18 001038656.1_39727001_3 - 1.7e-34 118.7 9.1 1.7e-34 118.7 9.1 2.2 3 0 0 3 3 3 1 DHHC palmitoyltransferase Annexin PF00191.18 001082739.1_37925001_1 - 5.9e-103 336.9 12.1 5.9e-26 90.2 0.3 4.2 4 0 0 4 4 4 4 Annexin Peptidase_M13_N PF05649.11 001397.2_26229001_1 - 1.2e-125 420.0 0.3 1.6e-125 419.7 0.3 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.19 001397.2_26229001_1 - 4.3e-74 248.4 0.0 8.3e-74 247.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M13 Apolipoprotein PF01442.16 001101687.1_37922001_2 - 4.8e-48 163.5 14.1 4.8e-48 163.5 14.1 1.3 2 0 0 2 2 1 1 Apolipoprotein A1/A4/E domain ApoLp-III PF07464.9 001101687.1_37922001_2 - 4.3e-07 30.0 7.5 0.00025 21.0 3.3 2.9 1 1 0 2 2 2 2 Apolipophorin-III precursor (apoLp-III) YtxH PF12732.5 001101687.1_37922001_2 - 1.4e-06 28.6 9.2 0.036 14.5 2.3 4.6 1 1 2 3 3 3 2 YtxH-like protein DUF883 PF05957.11 001101687.1_37922001_2 - 6.3e-06 26.6 10.4 0.31 11.5 1.2 3.9 2 1 2 4 4 3 3 Bacterial protein of unknown function (DUF883) Exonuc_VII_L PF02601.13 001101687.1_37922001_2 - 3.2e-05 23.5 7.0 5.3e-05 22.8 7.0 1.4 1 1 0 1 1 1 1 Exonuclease VII, large subunit DUF948 PF06103.9 001101687.1_37922001_2 - 6.7e-05 22.9 1.0 0.051 13.7 0.1 3.7 1 1 2 3 3 3 1 Bacterial protein of unknown function (DUF948) Baculo_PEP_C PF04513.10 001101687.1_37922001_2 - 9e-05 22.4 1.4 0.28 11.1 0.1 3.2 1 1 2 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus OmpH PF03938.12 001101687.1_37922001_2 - 9.9e-05 22.3 12.0 0.011 15.7 7.5 2.4 1 1 2 3 3 3 3 Outer membrane protein (OmpH-like) DUF4455 PF14643.4 001101687.1_37922001_2 - 0.00028 19.6 8.2 0.04 12.5 0.3 3.0 2 1 1 3 3 3 2 Domain of unknown function (DUF4455) Gp-FAR-1 PF05823.10 001101687.1_37922001_2 - 0.00032 20.9 4.0 0.05 13.8 0.4 3.0 1 1 1 2 2 2 1 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DHC_N1 PF08385.10 001101687.1_37922001_2 - 0.00069 18.2 1.2 0.0011 17.6 0.8 1.4 1 1 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 DUF1664 PF07889.10 001101687.1_37922001_2 - 0.0012 18.7 1.8 0.019 14.8 0.5 2.7 1 1 3 4 4 4 1 Protein of unknown function (DUF1664) TipAS PF07739.11 001101687.1_37922001_2 - 0.0015 18.9 7.7 1.2 9.6 0.9 3.4 1 1 2 3 3 3 2 TipAS antibiotic-recognition domain NPV_P10 PF05531.10 001101687.1_37922001_2 - 0.0017 18.7 3.0 0.37 11.1 0.0 3.4 2 1 2 4 4 3 1 Nucleopolyhedrovirus P10 protein DUF1640 PF07798.9 001101687.1_37922001_2 - 0.0017 18.3 5.3 0.074 13.0 2.2 2.4 1 1 1 2 2 2 1 Protein of unknown function (DUF1640) Bacillus_HBL PF05791.9 001101687.1_37922001_2 - 0.003 17.2 1.2 0.031 13.9 0.3 2.5 1 1 1 2 2 2 2 Bacillus haemolytic enterotoxin (HBL) GrpE PF01025.17 001101687.1_37922001_2 - 0.0067 16.0 11.1 4.5 6.8 11.1 2.8 1 1 0 1 1 1 0 GrpE DcpS_C PF11969.6 001101687.1_37922001_2 - 0.0071 16.7 0.3 0.3 11.4 0.0 2.5 2 1 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding Mating_N PF12731.5 001101687.1_37922001_2 - 0.0083 16.1 1.2 4.6 7.3 0.1 3.8 1 1 2 4 4 4 0 Mating-type protein beta 1 HIP1_clath_bdg PF16515.3 001101687.1_37922001_2 - 0.01 16.3 3.3 0.01 16.3 3.3 3.1 1 1 2 3 3 2 1 Clathrin-binding domain of Huntingtin-interacting protein 1 Spc7 PF08317.9 001101687.1_37922001_2 - 0.01 14.6 12.2 0.011 14.5 9.8 1.9 1 1 1 2 2 2 0 Spc7 kinetochore protein Transcrip_act PF04949.11 001101687.1_37922001_2 - 0.015 15.1 6.9 0.075 12.8 1.7 2.3 1 1 1 2 2 2 0 Transcriptional activator Prominin PF05478.9 001101687.1_37922001_2 - 0.015 13.1 2.5 0.057 11.2 1.2 1.9 1 1 1 2 2 2 0 Prominin ApoC-I PF04691.10 001101687.1_37922001_2 - 0.017 14.9 5.0 3.8 7.4 0.1 4.4 2 1 0 3 3 3 0 Apolipoprotein C-I (ApoC-1) LMP PF04778.10 001101687.1_37922001_2 - 0.019 14.7 1.1 0.019 14.7 1.1 2.6 1 1 1 3 3 2 0 LMP repeated region FAM184 PF15665.3 001101687.1_37922001_2 - 0.021 14.5 11.6 0.26 10.9 7.8 2.4 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B WXG100 PF06013.10 001101687.1_37922001_2 - 0.027 14.6 4.0 0.19 11.9 0.2 3.7 1 1 2 3 3 3 0 Proteins of 100 residues with WXG Laminin_II PF06009.10 001101687.1_37922001_2 - 0.033 14.1 3.7 0.37 10.7 0.4 2.7 1 1 1 2 2 2 0 Laminin Domain II RRF PF01765.17 001101687.1_37922001_2 - 0.039 13.8 4.5 0.12 12.2 1.1 2.7 1 1 2 3 3 3 0 Ribosome recycling factor Sds3 PF08598.9 001101687.1_37922001_2 - 0.043 13.7 5.3 0.15 12.0 2.6 2.3 2 0 0 2 2 2 0 Sds3-like TBPIP PF07106.11 001101687.1_37922001_2 - 0.048 13.3 11.1 0.25 11.0 2.7 2.8 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) BshC PF10079.7 001101687.1_37922001_2 - 0.051 12.2 7.7 0.052 12.1 5.8 1.7 1 1 1 2 2 2 0 Bacillithiol biosynthesis BshC HisKA_3 PF07730.11 001101687.1_37922001_2 - 0.052 14.0 6.4 67 4.0 0.0 3.6 2 1 0 2 2 2 0 Histidine kinase CREPT PF16566.3 001101687.1_37922001_2 - 0.073 13.1 10.0 1.1 9.3 2.9 2.6 1 1 2 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour THOC7 PF05615.11 001101687.1_37922001_2 - 0.088 13.0 7.7 0.087 13.0 4.3 2.1 1 1 1 2 2 2 0 Tho complex subunit 7 DUF4407 PF14362.4 001101687.1_37922001_2 - 0.11 11.7 4.5 0.16 11.2 4.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Nup54 PF13874.4 001101687.1_37922001_2 - 0.11 12.5 9.4 0.086 12.8 2.3 2.4 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 T7SS_ESX_EspC PF10824.6 001101687.1_37922001_2 - 0.12 12.8 0.1 4 7.8 0.1 2.8 1 1 1 3 3 3 0 Excreted virulence factor EspC, type VII ESX diderm DUF3584 PF12128.6 001101687.1_37922001_2 - 0.13 9.6 9.7 0.17 9.3 9.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Snapin_Pallidin PF14712.4 001101687.1_37922001_2 - 0.14 12.5 10.3 0.19 12.0 0.6 3.5 2 1 1 3 3 3 0 Snapin/Pallidin ApoO PF09769.7 001101687.1_37922001_2 - 0.15 11.9 4.5 9.3 6.1 0.1 3.7 1 1 3 4 4 4 0 Apolipoprotein O Seryl_tRNA_N PF02403.20 001101687.1_37922001_2 - 0.16 12.1 6.4 4 7.6 5.5 2.8 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Sas10_Utp3 PF04000.13 001101687.1_37922001_2 - 0.16 12.4 7.3 33 5.1 2.1 4.0 3 1 0 3 3 3 0 Sas10/Utp3/C1D family MIF4G_like_2 PF09090.9 001101687.1_37922001_2 - 0.17 11.2 8.4 2.1 7.6 8.4 2.0 1 1 0 1 1 1 0 MIF4G like Fzo_mitofusin PF04799.11 001101687.1_37922001_2 - 0.18 11.2 5.6 1.4 8.2 1.3 2.8 1 1 2 3 3 3 0 fzo-like conserved region Muted PF14942.4 001101687.1_37922001_2 - 0.18 12.0 9.6 1.1 9.5 5.7 2.6 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein Cor1 PF04803.10 001101687.1_37922001_2 - 0.18 11.9 6.6 0.12 12.5 3.7 2.2 1 1 1 3 3 2 0 Cor1/Xlr/Xmr conserved region MscS_porin PF12795.5 001101687.1_37922001_2 - 0.19 11.1 11.0 0.39 10.1 11.0 1.5 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain KMP11 PF03037.14 001101687.1_37922001_2 - 0.2 12.3 2.9 0.59 10.8 1.5 2.5 1 1 1 2 2 1 0 Kinetoplastid membrane protein 11 DctP PF03480.11 001101687.1_37922001_2 - 0.27 10.4 4.7 0.25 10.5 2.3 2.0 1 1 1 2 2 2 0 Bacterial extracellular solute-binding protein, family 7 Phasin PF05597.9 001101687.1_37922001_2 - 0.28 11.1 8.7 1.3 8.9 4.6 3.3 1 1 2 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) MRP-S27 PF10037.7 001101687.1_37922001_2 - 0.35 9.6 11.1 0.058 12.2 5.6 2.0 1 1 1 2 2 2 0 Mitochondrial 28S ribosomal protein S27 DUF1690 PF07956.9 001101687.1_37922001_2 - 0.4 11.0 10.9 0.48 10.7 1.7 2.8 1 1 2 3 3 3 0 Protein of Unknown function (DUF1690) DUF2884 PF11101.6 001101687.1_37922001_2 - 0.43 9.9 5.9 0.85 8.9 3.3 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF2884) Uso1_p115_C PF04871.11 001101687.1_37922001_2 - 0.46 10.7 13.9 6.5 7.0 3.5 2.9 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF2937 PF11157.6 001101687.1_37922001_2 - 0.48 10.0 2.7 0.88 9.1 0.3 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF2937) YlqD PF11068.6 001101687.1_37922001_2 - 0.49 10.6 8.3 2.9 8.1 5.7 2.3 1 1 1 2 2 2 0 YlqD protein DUF148 PF02520.15 001101687.1_37922001_2 - 0.53 10.3 5.1 2.6 8.1 1.9 3.0 1 1 1 2 2 2 0 Domain of unknown function DUF148 Prefoldin PF02996.15 001101687.1_37922001_2 - 0.54 10.0 4.1 1.9 8.3 0.4 3.1 2 1 1 3 3 3 0 Prefoldin subunit DUF4337 PF14235.4 001101687.1_37922001_2 - 0.61 10.0 6.8 1.4 8.9 1.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) IncA PF04156.12 001101687.1_37922001_2 - 0.63 9.7 15.4 2.3 7.8 13.5 2.3 1 1 1 2 2 2 0 IncA protein TMPIT PF07851.11 001101687.1_37922001_2 - 0.78 8.8 5.2 2.2 7.3 4.4 2.0 1 1 1 2 2 2 0 TMPIT-like protein LPP PF04728.11 001101687.1_37922001_2 - 0.87 9.9 4.3 22 5.4 1.0 3.9 2 2 1 3 3 3 0 Lipoprotein leucine-zipper FlxA PF14282.4 001101687.1_37922001_2 - 0.9 9.4 5.4 2.2 8.2 1.0 2.5 1 1 0 2 2 2 0 FlxA-like protein DUF342 PF03961.11 001101687.1_37922001_2 - 1.4 7.3 5.3 0.92 7.9 2.9 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF342) DUF4795 PF16043.3 001101687.1_37922001_2 - 1.4 8.3 9.5 6.3 6.2 8.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) ADIP PF11559.6 001101687.1_37922001_2 - 1.6 8.7 8.0 2.4 8.1 0.6 2.4 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF2203 PF09969.7 001101687.1_37922001_2 - 1.7 9.3 6.6 21 5.7 0.9 2.9 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) APG6 PF04111.10 001101687.1_37922001_2 - 2.7 7.1 11.0 7.4 5.7 10.9 1.7 1 1 0 1 1 1 0 Autophagy protein Apg6 AATF-Che1 PF13339.4 001101687.1_37922001_2 - 3.9 8.0 10.1 2.8 8.5 2.0 2.7 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor Kinetocho_Slk19 PF12709.5 001101687.1_37922001_2 - 4.1 7.8 7.9 7.4 7.0 1.2 3.7 1 1 2 3 3 3 0 Central kinetochore-associated Remorin_C PF03763.11 001101687.1_37922001_2 - 4.7 7.0 8.6 1.4 8.8 1.0 2.8 1 1 2 3 3 3 0 Remorin, C-terminal region AHSP PF09236.8 001101687.1_37922001_2 - 5 7.5 5.8 10 6.5 0.6 3.2 2 1 1 3 3 3 0 Alpha-haemoglobin stabilising protein FUSC PF04632.10 001101687.1_37922001_2 - 5.6 5.3 5.7 4.2 5.7 0.9 1.8 1 1 1 2 2 2 0 Fusaric acid resistance protein family FliT PF05400.11 001101687.1_37922001_2 - 7.2 7.4 12.2 8.5 7.1 3.4 3.2 1 1 2 3 3 3 0 Flagellar protein FliT MFS_1_like PF12832.5 001097457.1_49825001_3 - 2e-93 313.2 7.3 2.7e-93 312.8 7.3 1.2 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.14 001097457.1_49825001_3 - 3.6e-31 108.2 21.8 1.3e-16 60.4 11.6 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily Nuc_H_symport PF03825.14 001097457.1_49825001_3 - 8.2e-08 31.5 7.4 8.2e-08 31.5 7.4 4.1 3 1 2 5 5 5 3 Nucleoside H+ symporter LacY_symp PF01306.17 001097457.1_49825001_3 - 5.8e-07 28.5 18.0 0.0015 17.2 3.8 3.2 3 0 0 3 3 3 3 LacY proton/sugar symporter MFS_3 PF05977.11 001097457.1_49825001_3 - 0.00098 17.5 2.1 0.0011 17.3 0.9 1.6 2 0 0 2 2 2 1 Transmembrane secretion effector MFS_2 PF13347.4 001097457.1_49825001_3 - 0.0022 16.5 16.6 0.17 10.3 0.0 3.8 2 1 1 3 3 3 1 MFS/sugar transport protein OATP PF03137.18 001097457.1_49825001_3 - 0.095 10.9 6.8 1.4 7.0 0.7 3.1 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF3671 PF12420.6 001097457.1_49825001_3 - 0.1 12.5 0.0 4.7 7.2 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function UL45 PF05473.10 001097457.1_49825001_3 - 0.14 11.6 0.0 6.3 6.3 0.0 2.8 2 0 0 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like TMIE PF16038.3 001097457.1_49825001_3 - 0.17 11.6 0.0 0.56 10.0 0.0 1.8 1 0 0 1 1 1 0 TMIE protein Ets PF00178.20 001081479.1_39724001_1 - 1.5e-33 114.9 2.6 2.4e-33 114.3 2.6 1.3 1 0 0 1 1 1 1 Ets-domain THEG PF14912.4 001082366.1_37923001_1 - 0.00058 20.1 13.3 2.4 8.6 0.2 5.5 3 3 2 5 5 5 4 Testicular haploid expressed repeat Cornifin PF02389.13 001082366.1_37923001_3 - 5e-60 201.4 50.1 3e-36 124.5 20.6 2.9 2 1 1 3 3 3 2 Cornifin (SPRR) family Serum_albumin PF00273.18 001082204.1_37924001_1 - 1.6e-86 288.4 31.1 4.3e-48 163.3 2.5 3.1 3 0 0 3 3 3 3 Serum albumin family VitD-bind_III PF09164.8 001082204.1_37924001_1 - 2.8e-31 107.1 34.3 5.2e-30 103.1 2.6 5.8 5 2 1 6 6 6 4 Vitamin D binding protein, domain III DUF4144 PF13642.4 001082204.1_37924001_1 - 0.019 15.4 1.8 16 6.0 0.1 4.0 4 0 0 4 4 4 0 protein structure with unknown function PTPA PF03095.13 001082680.1_37924001_1 - 5.7e-125 416.6 0.0 6.7e-125 416.4 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein SLC3A2_N PF16028.3 001082656.1_37925001_1 - 2.2e-32 110.3 1.3 3.8e-32 109.5 1.3 1.3 1 0 0 1 1 1 1 Solute carrier family 3 member 2 N-terminus Alpha-amylase PF00128.22 001082656.1_37925001_1 - 1.2e-18 67.7 0.0 1.7e-11 44.2 0.0 3.1 1 1 1 3 3 3 3 Alpha amylase, catalytic domain DUF3459 PF11941.6 001082656.1_37925001_1 - 0.00042 20.4 0.4 0.001 19.2 0.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3459) Malt_amylase_C PF16657.3 001082656.1_37925001_1 - 0.0072 16.3 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain Integrin_beta PF00362.16 001097423.1_49826001_1 - 1.2e-109 365.6 0.0 1.8e-109 365.1 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.9 001097423.1_49826001_1 - 3.9e-20 71.1 0.1 7.3e-20 70.2 0.1 1.5 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.10 001097423.1_49826001_1 - 2.3e-17 63.1 6.3 2.3e-17 63.1 6.3 3.6 2 1 3 5 5 5 1 Integrin beta tail domain PSI_integrin PF17205.1 001097423.1_49826001_1 - 1.7e-14 53.3 3.8 1.7e-14 53.3 3.8 4.8 4 1 0 4 4 4 1 Integrin plexin domain EGF_2 PF07974.11 001097423.1_49826001_1 - 8.1e-06 26.0 102.9 0.00037 20.7 15.7 6.4 6 1 1 7 7 7 4 EGF-like domain GST_C_2 PF13410.4 001082111.1_37922001_1 - 2.3e-08 33.7 0.0 7e-08 32.2 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.4 001082111.1_37922001_1 - 2.5e-07 30.8 0.0 4.6e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.4 001082111.1_37922001_1 - 5.4e-07 29.8 0.0 1.2e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 001082111.1_37922001_1 - 0.00044 20.3 0.0 0.0012 18.9 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.2 001082111.1_37922001_1 - 0.061 14.0 0.0 0.1 13.2 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain Mit_proteolip PF08039.9 001082671.1_37925001_1 - 1.4 9.2 7.3 5 7.4 7.3 1.9 1 0 0 1 1 1 0 Mitochondrial proteolipid 7tm_1 PF00001.19 001082671.1_37925001_2 - 7.9e-23 80.9 8.0 7.9e-23 80.9 8.0 2.1 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) adh_short PF00106.23 001082749.1_37923001_2 - 3.8e-30 104.7 0.0 6.4e-23 81.1 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.4 001082749.1_37923001_2 - 3e-25 89.0 0.0 2.1e-17 63.4 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001082749.1_37923001_2 - 1.6e-05 24.8 0.1 2.6e-05 24.1 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.19 001082749.1_37923001_2 - 0.0029 17.0 0.0 0.0042 16.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family ubiquitin PF00240.21 001082212.1_37921001_1 - 4.5e-27 93.5 0.3 6e-27 93.0 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 001082212.1_37921001_1 - 6.7e-16 57.7 0.4 8.8e-16 57.4 0.4 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 001082212.1_37921001_1 - 8e-05 22.9 0.1 0.00014 22.1 0.1 1.4 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 001082212.1_37921001_1 - 0.057 13.4 0.1 0.11 12.4 0.1 1.5 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like RIIa PF02197.15 001082626.1_37923001_1 - 5.7e-15 54.6 0.2 1e-14 53.8 0.2 1.4 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit IQ PF00612.25 001082626.1_37923001_1 - 1.4e-05 24.4 0.0 3.5e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif WAP PF00095.19 001135853.1_39722001_3 - 2.9e-08 33.8 13.0 2.9e-08 33.8 13.0 2.3 3 0 0 3 3 3 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Collagen PF01391.16 001082666.1_37925001_1 - 3.9e-60 199.4 282.8 2.4e-07 30.3 24.6 10.6 2 1 7 9 9 9 7 Collagen triple helix repeat (20 copies) C1q PF00386.19 001082666.1_37925001_1 - 3.5e-37 127.3 0.0 4.4e-37 127.0 0.0 1.1 1 0 0 1 1 1 1 C1q domain Ribosomal_L9_N PF01281.17 001168959.1_40422001_1 - 3.6e-16 58.3 0.0 1e-15 56.8 0.0 1.8 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain Sugar_tr PF00083.22 001082202.1_37924001_1 - 1.4e-98 330.6 10.1 1.6e-98 330.4 10.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001082202.1_37924001_1 - 2.4e-13 49.6 15.7 2.4e-13 49.6 15.7 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily HSP90 PF00183.16 001098572.1_39726001_3 - 6.9e-243 807.0 34.7 1.2e-242 806.2 34.7 1.3 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.24 001098572.1_39726001_3 - 5.5e-13 49.3 0.1 1.4e-12 48.0 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.4 001098572.1_39726001_3 - 4e-12 46.0 0.1 1.1e-11 44.6 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Zip PF02535.20 001098572.1_39726001_3 - 0.19 10.8 1.4 0.4 9.7 1.4 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.12 001098572.1_39726001_3 - 6.5 4.8 17.7 13 3.8 17.7 1.4 1 0 0 1 1 1 0 CDC45-like protein CortBP2 PF09727.7 001171037.1_37929001_3 - 6.4e-38 130.4 37.8 2.6e-32 112.2 1.8 3.3 2 1 1 3 3 3 3 Cortactin-binding protein-2 Ank_2 PF12796.5 001171037.1_37929001_3 - 1.5e-36 124.7 7.0 1.8e-16 60.3 3.8 3.5 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001171037.1_37929001_3 - 1.4e-32 111.5 3.2 8.2e-13 48.5 0.3 4.8 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.4 001171037.1_37929001_3 - 8.7e-24 83.1 10.8 1.4e-08 34.7 0.1 5.9 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.28 001171037.1_37929001_3 - 2.1e-22 78.3 5.6 8.5e-05 22.7 0.0 6.0 5 0 0 5 5 5 5 Ankyrin repeat Ank_3 PF13606.4 001171037.1_37929001_3 - 3.7e-18 63.6 2.4 0.00079 19.6 0.0 6.9 6 0 0 6 6 6 5 Ankyrin repeat Spc7 PF08317.9 001171037.1_37929001_3 - 2 7.1 29.7 4.5 5.9 29.7 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF2347 PF09804.7 001171037.1_37929001_3 - 4.3 6.7 6.1 8.5 5.7 6.1 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) DUF4407 PF14362.4 001171037.1_37929001_3 - 5.6 6.1 14.9 11 5.1 14.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Laminin_II PF06009.10 001171037.1_37929001_3 - 8.2 6.3 15.0 0.31 10.9 8.4 2.0 2 0 0 2 2 2 0 Laminin Domain II COX7C PF02935.14 001079922.2_39721001_2 - 6.1e-23 80.7 0.1 8.3e-23 80.3 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc WAP PF00095.19 001082354.1_37922001_1 - 1.7e-17 63.4 41.4 2.7e-10 40.4 13.5 2.5 3 0 0 3 3 3 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' WD40 PF00400.30 001168972.1_40424001_1 - 0.02 15.6 9.5 5.3 8.0 0.0 5.1 5 0 0 5 5 5 0 WD domain, G-beta repeat 7tm_1 PF00001.19 001112629.1_40423001_1 - 1.4e-46 158.8 23.4 2.4e-46 158.0 23.4 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001112629.1_40423001_1 - 4.8e-06 26.0 23.2 6.1e-06 25.7 23.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001112629.1_40423001_1 - 0.8 9.2 20.0 6.2 6.3 20.0 2.5 1 1 0 1 1 1 0 Olfactory receptor SCF PF02404.13 214269.2_49823001_1 - 4.7e-152 504.8 2.2 5.4e-152 504.6 2.2 1.0 1 0 0 1 1 1 1 Stem cell factor DUF4448 PF14610.4 214269.2_49823001_1 - 0.036 13.7 0.0 0.055 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) IL4 PF00727.16 001112653.2_40421001_1 - 7.7e-48 161.2 4.1 9.4e-48 160.9 4.1 1.1 1 0 0 1 1 1 1 Interleukin 4 IL13 PF03487.11 001112653.2_40421001_1 - 0.0043 16.8 5.3 0.4 10.4 0.2 3.0 1 1 2 3 3 3 2 Interleukin-13 Mannosyl_trans3 PF11051.6 001112653.2_40421001_1 - 0.076 12.2 0.0 0.097 11.8 0.0 1.1 1 0 0 1 1 1 0 Mannosyltransferase putative DUF1907 PF08925.9 001112653.2_40421001_1 - 0.078 12.3 0.1 0.12 11.7 0.0 1.2 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1907) RRM_1 PF00076.20 001071801.1_39723001_1 - 8.6e-78 256.0 0.5 1.1e-21 76.3 0.1 4.1 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 001071801.1_39723001_1 - 1.3e-13 50.5 0.0 0.0001 21.8 0.0 3.3 2 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001071801.1_39723001_1 - 1.3e-09 37.7 0.0 0.00013 21.6 0.0 3.3 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_7 PF16367.3 001071801.1_39723001_1 - 7.1e-06 25.9 0.1 0.65 10.0 0.0 4.7 4 2 0 4 4 4 2 RNA recognition motif RRM_3 PF08777.9 001071801.1_39723001_1 - 7.1e-05 22.7 0.6 0.047 13.6 0.1 2.9 3 0 0 3 3 3 2 RNA binding motif Nup35_RRM_2 PF14605.4 001071801.1_39723001_1 - 0.00027 20.7 0.8 10 6.0 0.0 4.1 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif TC1 PF15063.4 001071801.1_39723001_1 - 0.001 18.7 0.0 0.054 13.2 0.0 2.7 3 0 0 3 3 3 1 Thyroid cancer protein 1 DUF4523 PF15023.4 001071801.1_39723001_1 - 0.058 13.1 0.0 5.2 6.7 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4523) SET_assoc PF11767.6 001071801.1_39723001_1 - 0.097 12.2 0.1 3.3 7.3 0.0 2.8 3 0 0 3 3 3 0 Histone lysine methyltransferase SET associated Crystall PF00030.17 001089317.1_37922001_3 - 2e-59 197.6 0.2 2.6e-30 104.3 0.0 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 001089317.1_37922001_3 - 7.9e-06 25.6 0.0 0.028 14.2 0.0 2.3 2 0 0 2 2 2 2 Peptidase inhibitor family I36 Crystall_3 PF08964.8 001089317.1_37922001_3 - 2.7e-05 24.1 0.2 0.18 11.9 0.1 3.2 3 0 0 3 3 3 2 Beta/Gamma crystallin Sortilin-Vps10 PF15902.3 001082664.1_37929001_1 - 8.4e-113 377.4 0.0 1.3e-112 376.7 0.0 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Ldl_recept_a PF00057.16 001082664.1_37929001_1 - 3.5e-109 356.6 209.3 1.6e-13 50.5 13.0 11.9 12 0 0 12 12 11 11 Low-density lipoprotein receptor domain class A Sortilin_C PF15901.3 001082664.1_37929001_1 - 6.5e-41 140.4 0.1 6.5e-41 140.4 0.1 5.2 4 1 2 6 6 1 1 Sortilin, neurotensin receptor 3, C-terminal fn3 PF00041.19 001082664.1_37929001_1 - 5.4e-39 132.3 14.1 5.3e-10 39.4 0.3 6.6 6 0 0 6 6 6 5 Fibronectin type III domain Ldl_recept_b PF00058.15 001082664.1_37929001_1 - 1.2e-24 86.3 8.6 2.9e-06 27.5 0.2 5.7 5 0 0 5 5 5 4 Low-density lipoprotein receptor repeat class B Pur_ac_phosph_N PF16656.3 001082664.1_37929001_1 - 3.1e-07 30.8 17.4 0.024 15.0 0.1 6.1 6 0 0 6 6 6 3 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 001082664.1_37929001_1 - 1e-06 28.8 7.1 0.097 12.9 0.8 5.2 5 0 0 5 5 5 1 Interferon-alpha/beta receptor, fibronectin type III BNR_6 PF15899.3 001082664.1_37929001_1 - 0.00079 19.1 2.4 1.2 9.3 0.1 3.5 2 0 0 2 2 2 2 BNR-Asp box repeat DUF4945 PF16303.3 001082664.1_37929001_1 - 0.0031 17.3 1.5 0.12 12.2 0.3 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4945) BNR PF02012.18 001082664.1_37929001_1 - 0.0032 17.1 15.6 1.8 8.7 0.1 5.6 5 0 0 5 5 5 1 BNR/Asp-box repeat Tissue_fac PF01108.15 001082664.1_37929001_1 - 0.011 15.4 8.2 8.4 6.1 3.0 4.9 3 1 1 4 4 4 0 Tissue factor fn3_2 PF16893.3 001082664.1_37929001_1 - 0.085 12.9 5.7 6.7 6.8 0.0 4.9 6 0 0 6 6 6 0 Fibronectin type III domain EF1_GNE PF00736.17 001082369.1_37922001_1 - 6.8e-36 122.2 0.2 1.7e-35 120.9 0.2 1.7 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.7 001082369.1_37922001_1 - 5.4e-12 45.8 8.9 5.4e-12 45.8 8.9 2.6 2 0 0 2 2 1 1 Eukaryotic elongation factor 1 beta central acidic region Striatin PF08232.10 001082369.1_37922001_1 - 0.00015 22.2 3.2 0.00027 21.4 3.2 1.3 1 0 0 1 1 1 1 Striatin family Trimer_CC PF08954.9 001082369.1_37922001_1 - 0.012 15.0 3.8 0.036 13.5 0.2 3.1 3 0 0 3 3 3 0 Trimerisation motif CCD48 PF15799.3 001082369.1_37922001_1 - 0.021 13.1 4.3 0.034 12.4 3.7 1.4 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 48 TolA_bind_tri PF16331.3 001082369.1_37922001_1 - 0.037 14.0 0.4 0.1 12.6 0.0 1.9 2 0 0 2 2 2 0 TolA binding protein trimerisation MinC_N PF05209.11 001082369.1_37922001_1 - 0.05 13.4 0.0 0.87 9.4 0.0 2.2 2 0 0 2 2 2 0 Septum formation inhibitor MinC, N-terminal domain PilJ PF13675.4 001082369.1_37922001_1 - 0.11 12.4 1.5 0.29 11.1 1.5 1.8 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term PRKG1_interact PF15898.3 001082369.1_37922001_1 - 0.21 12.4 3.7 0.54 11.1 3.7 1.6 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain SlyX PF04102.10 001082369.1_37922001_1 - 0.21 12.1 1.8 0.47 11.0 0.6 2.1 2 0 0 2 2 2 0 SlyX TSC22 PF01166.16 001082369.1_37922001_1 - 0.23 11.6 1.4 5 7.4 0.1 2.6 2 1 1 3 3 3 0 TSC-22/dip/bun family WD40_alt PF14077.4 001082369.1_37922001_1 - 0.23 11.2 2.0 0.34 10.7 0.1 2.3 2 0 0 2 2 2 0 Alternative WD40 repeat motif KASH_CCD PF14662.4 001082369.1_37922001_1 - 0.41 10.3 5.4 0.3 10.8 1.4 2.2 2 1 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH Lzipper-MIP1 PF14389.4 001082369.1_37922001_1 - 0.66 10.1 5.5 5.1 7.3 0.1 2.8 3 0 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 RF-1 PF00472.18 001082369.1_37922001_1 - 1.9 8.3 5.1 0.33 10.8 0.5 2.1 2 1 0 2 2 2 0 RF-1 domain Ets PF00178.20 001081568.1_39722001_1 - 1.3e-33 115.1 3.6 4.7e-33 113.4 0.5 2.5 2 0 0 2 2 2 1 Ets-domain SAM_PNT PF02198.14 001081568.1_39722001_1 - 9.4e-26 89.5 1.8 1.8e-25 88.6 1.2 1.8 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain MVL PF12151.6 001081568.1_39722001_1 - 0.29 10.9 4.9 0.28 10.9 2.1 2.2 2 0 0 2 2 2 0 Mannan-binding protein V-set PF07686.15 001082685.2_37922001_1 - 3.3e-09 36.7 0.1 4.5e-09 36.3 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain V-set_2 PF15910.3 001082685.2_37922001_1 - 0.00013 21.9 0.0 0.00017 21.5 0.0 1.2 1 0 0 1 1 1 1 ICOS V-set domain Ig_3 PF13927.4 001082685.2_37922001_1 - 0.032 14.7 0.1 0.061 13.8 0.1 1.6 1 1 0 1 1 1 0 Immunoglobulin domain APOBEC_N PF08210.9 001082341.1_37922001_2 - 2.5e-29 102.3 0.2 3.9e-29 101.7 0.2 1.2 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001082341.1_37922001_2 - 2.2e-22 78.6 0.0 4.4e-22 77.7 0.0 1.4 1 0 0 1 1 1 1 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 001082341.1_37922001_2 - 0.019 14.7 0.0 0.029 14.1 0.0 1.3 1 0 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region Glyco_hydro_1 PF00232.16 001101689.1_37929001_1 - 0 1836.0 14.0 2.4e-185 616.2 5.1 4.2 4 0 0 4 4 4 4 Glycosyl hydrolase family 1 Integrin_beta PF00362.16 001113772.1_39525001_1 - 1.8e-109 365.1 0.0 2.7e-109 364.5 0.0 1.3 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.9 001113772.1_39525001_1 - 3.8e-20 71.2 0.1 6.8e-20 70.4 0.1 1.4 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain PSI_integrin PF17205.1 001113772.1_39525001_1 - 2.6e-14 52.6 5.0 2.6e-14 52.6 5.0 4.8 4 1 0 4 4 4 1 Integrin plexin domain Integrin_B_tail PF07965.10 001113772.1_39525001_1 - 3e-14 53.2 8.2 3e-14 53.2 8.2 3.9 4 1 2 6 6 6 1 Integrin beta tail domain EGF_2 PF07974.11 001113772.1_39525001_1 - 4.4e-06 26.8 56.4 0.00025 21.2 16.0 6.5 6 1 1 7 7 7 4 EGF-like domain HLH PF00010.24 001082635.1_37923001_1 - 4.4e-18 64.9 0.2 7.2e-18 64.2 0.2 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Rootletin PF15035.4 001082635.1_37923001_1 - 0.0042 17.0 4.0 0.0072 16.3 4.0 1.4 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion HALZ PF02183.16 001082635.1_37923001_1 - 1.7 8.8 8.6 1 9.5 2.2 2.2 1 1 1 2 2 2 0 Homeobox associated leucine zipper Laminin_G_2 PF02210.22 001047865.1_45728001_1 - 1.3e-84 281.0 3.9 2.4e-23 83.0 0.2 4.3 4 0 0 4 4 4 4 Laminin G domain Laminin_G_1 PF00054.21 001047865.1_45728001_1 - 1.3e-58 196.8 0.4 1.5e-15 57.4 0.0 4.4 4 0 0 4 4 4 4 Laminin G domain F5_F8_type_C PF00754.23 001047865.1_45728001_1 - 6.3e-28 97.3 3.0 2.8e-27 95.2 0.9 2.9 3 0 0 3 3 3 1 F5/8 type C domain Laminin_G_3 PF13385.4 001047865.1_45728001_1 - 2e-09 37.7 0.0 0.14 12.2 0.0 5.1 5 0 0 5 5 5 2 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.25 001047865.1_45728001_1 - 1.2e-05 25.4 41.7 0.00015 21.8 10.0 3.6 3 0 0 3 3 3 2 EGF-like domain EphA2_TM PF14575.4 001047865.1_45728001_1 - 0.16 12.7 0.1 0.32 11.7 0.1 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Med7 PF05983.9 001044615.1_49823001_1 - 2.2e-43 148.3 7.6 4.6e-43 147.3 7.6 1.5 1 1 0 1 1 1 1 MED7 protein DotU PF09850.7 001044615.1_49823001_1 - 0.0083 15.8 1.7 0.51 10.0 0.1 2.1 2 0 0 2 2 2 2 Type VI secretion system protein DotU L27_1 PF09058.8 001044615.1_49823001_1 - 0.13 12.2 0.4 0.27 11.2 0.4 1.5 1 0 0 1 1 1 0 L27_1 ITAM PF02189.13 001082002.1_37922001_1 - 4.1e-20 70.8 3.0 3.2e-05 24.0 0.1 3.3 3 0 0 3 3 3 3 Immunoreceptor tyrosine-based activation motif TCR_zetazeta PF11628.6 001082002.1_37922001_1 - 3e-17 61.8 1.1 4.7e-17 61.2 1.1 1.3 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 zeta chain AA_permease_2 PF13520.4 001082120.1_37927001_2 - 1.4e-62 211.8 37.5 1.8e-62 211.5 37.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.19 001082120.1_37927001_2 - 3.5e-23 81.8 32.7 5.2e-23 81.3 32.7 1.1 1 0 0 1 1 1 1 Amino acid permease SirB PF04247.10 001082120.1_37927001_2 - 0.032 14.2 6.7 1 9.3 0.3 2.7 2 0 0 2 2 2 0 Invasion gene expression up-regulator, SirB Sugar_tr PF00083.22 001082121.2_37925001_3 - 8.6e-38 130.2 11.1 1.2e-37 129.7 11.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001082121.2_37925001_3 - 1.3e-28 99.8 20.2 2e-28 99.2 20.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily KH_1 PF00013.27 001082125.1_37924001_1 - 3.8e-43 145.0 13.9 6.2e-20 70.7 1.9 3.3 3 0 0 3 3 3 3 KH domain ROKNT PF08067.9 001082125.1_37924001_1 - 1.8e-26 92.0 9.8 3e-26 91.3 9.8 1.4 1 0 0 1 1 1 1 ROKNT (NUC014) domain KH_2 PF07650.15 001082125.1_37924001_1 - 3.8e-14 52.1 5.5 0.00091 18.9 0.5 3.8 3 1 1 4 4 4 3 KH domain KH_4 PF13083.4 001082125.1_37924001_1 - 1.7e-08 34.1 4.8 7.2e-06 25.7 0.0 3.2 3 0 0 3 3 3 2 KH domain KH_5 PF13184.4 001082125.1_37924001_1 - 0.00041 20.2 6.1 0.35 10.8 0.1 3.6 3 1 0 3 3 3 2 NusA-like KH domain MOEP19 PF16005.3 001082125.1_37924001_1 - 0.031 14.2 0.0 1.7 8.6 0.0 2.2 2 0 0 2 2 2 0 KH-like RNA-binding domain DJ-1_PfpI PF01965.22 001082125.1_37924001_1 - 0.087 12.5 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 DJ-1/PfpI family Citrate_bind PF16114.3 001038622.1_39527001_1 - 2.3e-92 307.2 0.1 4.2e-92 306.4 0.1 1.4 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding Citrate_synt PF00285.19 001038622.1_39527001_1 - 1.2e-22 80.4 0.0 2.1e-19 69.7 0.0 2.9 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain Ligase_CoA PF00549.17 001038622.1_39527001_1 - 3.2e-13 49.6 0.1 6.7e-13 48.6 0.1 1.6 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.17 001038622.1_39527001_1 - 4.8e-12 46.3 0.0 1.1e-11 45.1 0.0 1.7 1 0 0 1 1 1 1 CoA binding domain ATP-grasp_2 PF08442.8 001038622.1_39527001_1 - 5.8e-06 25.9 0.0 1.1e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.4 001038622.1_39527001_1 - 0.0036 17.0 0.1 0.017 14.8 0.0 2.1 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain DUF2934 PF11154.6 001038622.1_39527001_2 - 0.041 13.4 0.1 0.073 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2934) Pkinase_Tyr PF07714.15 001171040.1_37929001_1 - 5.4e-93 310.9 0.0 8.4e-93 310.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Sema PF01403.17 001171040.1_37929001_1 - 7.4e-60 202.7 1.3 1.1e-59 202.1 1.3 1.2 1 0 0 1 1 1 1 Sema domain TIG PF01833.22 001171040.1_37929001_1 - 8.5e-40 134.6 13.4 2.4e-13 49.8 0.4 4.8 4 0 0 4 4 4 4 IPT/TIG domain Pkinase PF00069.23 001171040.1_37929001_1 - 1.2e-39 136.2 0.0 2e-39 135.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain PSI PF01437.23 001171040.1_37929001_1 - 2.1e-05 24.8 14.6 0.00013 22.3 14.6 2.5 1 0 0 1 1 1 1 Plexin repeat Kinase-like PF14531.4 001171040.1_37929001_1 - 0.00033 20.0 0.0 0.00059 19.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Asp PF00026.21 001082244.1_37924001_3 - 4.1e-118 394.2 0.0 5e-118 394.0 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001082244.1_37924001_3 - 7.9e-12 45.7 5.2 3.6e-09 37.0 0.3 2.5 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001082244.1_37924001_3 - 5.9e-10 38.7 0.1 1e-09 37.9 0.1 1.3 1 0 0 1 1 1 1 A1 Propeptide Thyroglobulin_1 PF00086.16 001040029.1_29622001_1 - 1.2e-11 44.0 2.8 1.2e-11 44.0 2.8 2.0 1 1 1 2 2 2 1 Thyroglobulin type-1 repeat DAG1 PF05454.9 001040029.1_29622001_1 - 0.012 14.8 1.1 0.021 14.1 1.1 1.3 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) DUF4064 PF13273.4 001040029.1_29622001_1 - 0.026 14.7 0.0 0.05 13.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) BCLP PF12304.6 001040029.1_29622001_1 - 0.039 13.4 0.8 0.078 12.4 0.8 1.4 1 0 0 1 1 1 0 Beta-casein like protein DUF1191 PF06697.10 001040029.1_29622001_1 - 0.04 13.0 0.5 0.14 11.2 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1191) ASFV_J13L PF05568.9 001040029.1_29622001_1 - 0.15 11.7 1.2 0.3 10.7 0.4 1.8 2 0 0 2 2 2 0 African swine fever virus J13L protein DUF2749 PF10907.6 001040029.1_29622001_1 - 0.2 11.7 1.6 0.46 10.6 1.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2749) Cys_rich_VLP PF14194.4 001040029.1_29622001_1 - 0.22 11.6 5.5 0.61 10.1 5.5 1.7 1 0 0 1 1 1 0 Cysteine-rich VLP Baculo_11_kDa PF06143.9 001040029.1_29622001_1 - 0.27 10.7 2.2 0.61 9.6 2.2 1.5 1 0 0 1 1 1 0 Baculovirus 11 kDa family Trp_oprn_chp PF09534.8 001040029.1_29622001_1 - 0.3 10.7 2.3 0.55 9.9 0.0 2.1 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) EphA2_TM PF14575.4 001040029.1_29622001_1 - 0.33 11.7 2.9 0.49 11.1 0.9 2.3 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain PMP1_2 PF08114.9 001040029.1_29622001_1 - 0.72 9.5 3.7 1.3 8.7 3.7 1.4 1 0 0 1 1 1 0 ATPase proteolipid family Arginase PF00491.19 001082181.1_37923001_1 - 7.6e-73 245.3 0.0 8.9e-73 245.1 0.0 1.0 1 0 0 1 1 1 1 Arginase family SRF-TF PF00319.16 001099698.1_49824001_1 - 5.6e-24 83.2 0.4 9.2e-24 82.5 0.4 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.6 001099698.1_49824001_1 - 5.4e-21 74.2 0.3 5.4e-21 74.2 0.3 3.2 4 0 0 4 4 4 1 Holliday junction regulator protein family C-terminal repeat Sod_Cu PF00080.18 001082627.1_37922001_1 - 5.1e-46 156.2 3.6 6.3e-46 155.9 3.6 1.1 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) zf-H2C2_2 PF13465.4 001081489.1_39724001_1 - 3.6e-44 147.2 65.0 1.4e-08 34.7 1.7 7.4 7 0 0 7 7 7 7 Zinc-finger double domain SCAN PF02023.15 001081489.1_39724001_1 - 1.6e-40 136.7 5.7 3.6e-40 135.5 5.7 1.6 1 0 0 1 1 1 1 SCAN domain zf-C2H2 PF00096.24 001081489.1_39724001_1 - 2e-36 122.3 71.4 4.1e-06 26.8 0.9 7.4 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001081489.1_39724001_1 - 1.3e-22 78.4 65.5 0.002 18.7 2.3 7.6 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001081489.1_39724001_1 - 1.9e-18 65.8 54.7 9.3e-05 22.2 2.5 7.4 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001081489.1_39724001_1 - 1.1e-05 25.4 31.9 0.35 11.1 0.2 7.5 6 1 1 7 7 7 3 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.3 001081489.1_39724001_1 - 3.1e-05 23.5 38.2 0.00093 18.8 1.4 7.0 7 0 0 7 7 7 2 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 001081489.1_39724001_1 - 0.00027 20.9 38.0 0.48 10.4 4.5 6.0 2 2 4 6 6 6 4 Zinc ribbon domain zf-met PF12874.5 001081489.1_39724001_1 - 0.0011 19.1 1.1 0.0011 19.1 1.1 7.2 7 0 0 7 7 7 1 Zinc-finger of C2H2 type DZR PF12773.5 001081489.1_39724001_1 - 0.0077 16.1 29.3 0.22 11.5 0.7 4.5 2 1 0 2 2 1 1 Double zinc ribbon zf-C2HE PF16278.3 001081489.1_39724001_1 - 0.053 13.9 0.6 0.053 13.9 0.6 7.4 1 1 6 7 7 7 0 C2HE / C2H2 / C2HC zinc-binding finger DUF3268 PF11672.6 001081489.1_39724001_1 - 0.077 13.2 0.6 0.077 13.2 0.6 4.5 2 1 4 6 6 6 0 zinc-finger-containing domain ROS_MUCR PF05443.9 001081489.1_39724001_1 - 0.091 12.7 3.7 0.088 12.7 0.9 2.5 2 1 0 2 2 2 0 ROS/MUCR transcriptional regulator protein zinc_ribbon_15 PF17032.3 001081489.1_39724001_1 - 0.73 10.5 25.7 1.1 10.0 3.4 4.3 1 1 3 4 4 4 0 zinc-ribbon family HypA PF01155.17 001081489.1_39724001_1 - 1.6 8.6 24.4 5 7.0 2.3 4.3 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA C1_4 PF07975.10 001081489.1_39724001_1 - 1.9 8.7 32.9 0.3 11.3 1.8 5.3 4 2 2 6 6 5 0 TFIIH C1-like domain zf-RING_7 PF02591.13 001081489.1_39724001_1 - 5.8 7.1 17.4 3.5 7.8 0.4 5.3 6 0 0 6 6 6 0 C4-type zinc ribbon domain zinc_ribbon_9 PF14369.4 001081489.1_39724001_1 - 6.4 7.0 26.7 1.3 9.2 0.1 6.3 6 1 0 6 6 5 0 zinc-ribbon zf-CHCC PF10276.7 001081489.1_39724001_1 - 6.4 6.8 22.9 2.9 7.9 0.3 6.0 6 0 0 6 6 6 0 Zinc-finger domain ADK_lid PF05191.12 001081489.1_39724001_1 - 9.7 6.2 23.3 1.7 8.6 1.8 4.3 3 1 2 5 5 5 0 Adenylate kinase, active site lid MHC_I_3 PF16497.3 001089312.1_37922001_1 - 1.7e-67 226.6 0.0 2.1e-67 226.3 0.0 1.1 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001089312.1_37922001_1 - 1.7e-09 37.9 0.0 7.1e-09 35.9 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001089312.1_37922001_1 - 4.2e-05 23.1 0.0 9.4e-05 21.9 0.0 1.6 1 1 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Pkinase_Tyr PF07714.15 001168714.1_40429001_2 - 8.9e-93 310.2 0.0 1.3e-92 309.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Sema PF01403.17 001168714.1_40429001_2 - 8.9e-56 189.3 2.4 1.3e-55 188.7 2.4 1.2 1 0 0 1 1 1 1 Sema domain Pkinase PF00069.23 001168714.1_40429001_2 - 1.2e-39 136.1 0.0 2.2e-39 135.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain TIG PF01833.22 001168714.1_40429001_2 - 1.8e-39 133.6 12.2 1.3e-13 50.7 0.9 4.6 4 0 0 4 4 4 4 IPT/TIG domain PSI PF01437.23 001168714.1_40429001_2 - 1.5e-05 25.3 15.7 7.2e-05 23.1 15.7 2.3 1 0 0 1 1 1 1 Plexin repeat Kinase-like PF14531.4 001168714.1_40429001_2 - 0.00034 19.9 0.0 0.00058 19.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like PSI_integrin PF17205.1 001168714.1_40429001_2 - 2.5 7.9 11.0 11 5.8 11.0 2.1 1 0 0 1 1 1 0 Integrin plexin domain Guanylate_kin PF00625.19 001082396.1_37927001_3 - 1e-49 168.5 0.1 1.9e-49 167.7 0.1 1.4 1 0 0 1 1 1 1 Guanylate kinase VGCC_beta4Aa_N PF12052.6 001082396.1_37927001_3 - 5.2e-23 80.8 6.5 1.9e-22 79.0 6.5 2.1 1 0 0 1 1 1 1 Voltage gated calcium channel subunit beta domain 4Aa N terminal SH3_1 PF00018.26 001082396.1_37927001_3 - 0.0041 16.6 0.1 0.011 15.2 0.1 1.7 2 0 0 2 2 2 1 SH3 domain Serpin PF00079.18 001168917.1_40423001_1 - 1.4e-130 435.8 8.6 1.6e-130 435.6 8.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Endothelin PF00322.15 001082012.1_37923001_2 - 2.4e-23 81.3 13.6 2.4e-20 71.6 6.2 2.7 2 0 0 2 2 2 2 Endothelin family Hist_rich_Ca-bd PF10529.7 001082234.1_37926001_2 - 3.5e-10 39.5 205.8 4.5e-05 23.3 1.2 26.5 24 4 0 24 24 24 13 Histidine-rich Calcium-binding repeat region 7tm_1 PF00001.19 001113064.1_49823001_1 - 2.6e-48 164.4 4.7 3.7e-48 164.0 4.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 001113064.1_49823001_1 - 0.0091 15.2 0.0 0.016 14.4 0.0 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw EF1_GNE PF00736.17 001082399.1_37922001_1 - 3.7e-37 126.2 0.8 6.3e-37 125.5 0.8 1.4 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.7 001082399.1_37922001_1 - 1.2e-13 51.1 9.1 3e-13 49.8 9.1 1.7 1 0 0 1 1 1 1 Eukaryotic elongation factor 1 beta central acidic region GST_C_3 PF14497.4 001082399.1_37922001_1 - 0.008 16.2 0.2 0.13 12.3 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.2 001082399.1_37922001_1 - 0.022 14.4 0.0 0.085 12.5 0.0 2.0 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Caveolin PF01146.15 001168711.1_40426001_3 - 6.7e-59 197.5 1.6 1.1e-58 196.8 1.6 1.3 1 0 0 1 1 1 1 Caveolin DAP10 PF07213.9 001081991.1_37925001_1 - 8.9e-17 60.7 0.1 2.1e-16 59.5 0.1 1.7 1 0 0 1 1 1 1 DAP10 membrane protein IFN-gamma PF00714.15 001081991.1_37925001_2 - 3.4e-65 217.9 3.8 5.3e-65 217.3 3.8 1.3 1 0 0 1 1 1 1 Interferon gamma DAP10 PF07213.9 001081991.1_37925001_3 - 1.3e-09 37.8 1.9 2.4e-09 36.9 1.9 1.3 1 0 0 1 1 1 1 DAP10 membrane protein MFS_1 PF07690.14 001082307.1_37924001_2 - 5.9e-45 153.6 29.9 2.2e-44 151.7 25.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Arylesterase PF01731.18 001082297.1_37923001_1 - 7.2e-39 131.7 1.4 8.7e-39 131.5 0.5 1.7 2 0 0 2 2 2 1 Arylesterase SGL PF08450.10 001082297.1_37923001_1 - 8.8e-11 41.7 0.0 3.1e-10 39.9 0.0 1.6 1 1 0 2 2 2 1 SMP-30/Gluconolaconase/LRE-like region Str_synth PF03088.14 001082297.1_37923001_1 - 2.6e-05 24.1 0.0 9.7e-05 22.3 0.0 2.0 2 0 0 2 2 2 1 Strictosidine synthase Lactonase PF10282.7 001082297.1_37923001_1 - 0.16 11.0 0.0 0.41 9.7 0.0 1.6 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller Annexin PF00191.18 001093788.1_39523001_1 - 1.4e-93 306.9 12.9 2.3e-27 94.7 0.5 4.2 4 0 0 4 4 4 4 Annexin 7tm_1 PF00001.19 001082175.2_37924001_2 - 1.3e-52 178.6 15.4 1.6e-52 178.2 15.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001082175.2_37924001_2 - 3.2e-14 52.8 12.4 6.1e-13 48.6 12.4 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001082175.2_37924001_2 - 1.2e-12 48.0 11.9 1.7e-11 44.2 11.9 2.5 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001082175.2_37924001_2 - 0.0029 16.8 5.3 0.0029 16.8 5.3 1.8 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Sri PF10327.7 001082175.2_37924001_2 - 0.0058 15.7 2.5 0.0058 15.7 2.5 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Sri Clusterin PF01093.15 001082049.2_37924001_2 - 9.3e-159 528.9 9.8 1.1e-158 528.7 9.8 1.0 1 0 0 1 1 1 1 Clusterin Mt_ATP-synt_B PF05405.12 001082049.2_37924001_2 - 1.4 8.4 6.4 0.29 10.6 1.0 2.4 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) RE_AlwI PF09491.8 001082049.2_37924001_2 - 2 7.0 6.4 0.31 9.7 1.2 1.9 2 0 0 2 2 2 0 AlwI restriction endonuclease zf-C4pol PF14260.4 001082049.2_37924001_2 - 2 8.8 10.3 0.72 10.2 1.2 2.7 2 0 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta TBPIP PF07106.11 001082049.2_37924001_2 - 3.6 7.2 12.3 0.27 10.9 5.4 2.3 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) PBD PF00786.26 001039044.1_45726001_1 - 0.0071 16.6 0.1 0.014 15.6 0.1 1.5 1 0 0 1 1 1 1 P21-Rho-binding domain Rhomboid_SP PF12595.6 001168814.1_40426001_1 - 2.4e-111 370.1 2.8 3.7e-111 369.5 2.8 1.3 1 0 0 1 1 1 1 Rhomboid serine protease Rhomboid PF01694.20 001168814.1_40426001_1 - 2e-28 99.1 8.6 2e-28 99.1 8.6 1.7 2 0 0 2 2 2 1 Rhomboid family Herpes_UL56 PF04534.10 001168814.1_40426001_1 - 0.34 10.2 4.3 0.38 10.1 2.6 1.9 1 1 0 1 1 1 0 Herpesvirus UL56 protein Ribosomal_S18 PF01084.18 001040115.1_39722001_1 - 1.2e-15 57.3 1.5 1.3e-15 57.2 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein S18 zf-RING_10 PF16685.3 001040115.1_39722001_1 - 0.06 13.4 1.3 0.27 11.3 0.5 2.1 2 0 0 2 2 2 0 zinc RING finger of MSL2 HTH_21 PF13276.4 001040115.1_39722001_1 - 0.062 13.3 0.3 0.19 11.8 0.3 1.8 1 0 0 1 1 1 0 HTH-like domain RecR PF02132.13 001040115.1_39722001_1 - 0.14 11.6 0.7 2.6 7.5 0.1 2.3 2 0 0 2 2 2 0 RecR protein GCR PF02155.13 001114186.1_39525001_1 - 3.5e-182 605.4 9.2 4.3e-182 605.1 9.2 1.1 1 0 0 1 1 1 1 Glucocorticoid receptor Hormone_recep PF00104.28 001114186.1_39525001_1 - 8.7e-30 103.7 5.3 4.3e-29 101.4 4.4 2.1 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001114186.1_39525001_1 - 2.8e-28 98.1 13.0 5.2e-28 97.2 13.0 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Pheromone PF08015.9 001114186.1_39525001_1 - 0.96 10.4 0.0 0.96 10.4 0.0 3.9 4 0 0 4 4 4 0 Fungal mating-type pheromone Aldo_ket_red PF00248.19 001082287.1_37923001_2 - 2.1e-54 184.5 0.0 2.9e-54 184.1 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family wnt PF00110.17 001168691.1_32325001_3 - 1.7e-122 408.6 25.9 2.1e-122 408.3 25.9 1.1 1 0 0 1 1 1 1 wnt family Ion_trans PF00520.29 001082779.1_37929001_3 - 4e-32 111.2 14.5 6.7e-32 110.5 14.5 1.3 1 0 0 1 1 1 1 Ion transport protein TRP_2 PF08344.9 001082779.1_37929001_3 - 4.1e-28 97.3 0.3 8.8e-28 96.2 0.3 1.6 1 0 0 1 1 1 1 Transient receptor ion channel II Ank_2 PF12796.5 001082779.1_37929001_3 - 1.2e-10 41.7 1.3 1.7e-06 28.4 0.4 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001082779.1_37929001_3 - 1.3e-06 28.7 0.0 0.039 14.4 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 001082779.1_37929001_3 - 1.5e-06 27.9 2.0 0.31 11.6 0.1 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.28 001082779.1_37929001_3 - 0.00024 21.3 0.5 0.15 12.5 0.0 3.1 2 0 0 2 2 2 1 Ankyrin repeat PKD_channel PF08016.10 001082779.1_37929001_3 - 0.00069 18.3 13.9 0.021 13.4 2.4 2.6 2 1 0 2 2 2 2 Polycystin cation channel Ank_5 PF13857.4 001082779.1_37929001_3 - 0.0073 16.5 0.3 3.3 8.1 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Gp-FAR-1 PF05823.10 001082779.1_37929001_3 - 0.37 11.0 4.1 11 6.2 0.1 2.7 3 0 0 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) PP2C PF00481.19 001082698.1_37925001_1 - 1.8e-89 299.7 0.0 2.2e-89 299.4 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_C PF07830.11 001082698.1_37925001_1 - 1.4e-32 111.8 0.2 2.3e-32 111.1 0.2 1.4 1 0 0 1 1 1 1 Protein serine/threonine phosphatase 2C, C-terminal domain IL8 PF00048.18 001082294.1_37922001_1 - 3.2e-21 75.1 2.3 5.8e-21 74.3 2.3 1.4 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like WAP PF00095.19 001082390.2_37922001_2 - 5e-13 49.1 22.4 1.3e-07 31.7 6.5 2.5 2 0 0 2 2 2 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' PGM_PMM_I PF02878.14 001082316.1_37926001_1 - 2.3e-35 121.2 0.0 3.5e-35 120.6 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.14 001082316.1_37926001_1 - 1.6e-30 105.5 0.0 2.9e-30 104.7 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.14 001082316.1_37926001_1 - 2.8e-17 63.1 0.0 5.1e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.18 001082316.1_37926001_1 - 2.1e-05 24.5 0.0 4.6e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain UT PF03253.12 001082340.1_37927001_2 - 3.2e-110 367.7 35.0 4e-110 367.4 35.0 1.1 1 0 0 1 1 1 1 Urea transporter Maelstrom PF13017.4 001097511.1_49824001_2 - 2.5e-57 193.9 0.3 3.5e-57 193.4 0.3 1.2 1 0 0 1 1 1 1 piRNA pathway germ-plasm component HMG_box_2 PF09011.8 001097511.1_49824001_2 - 7.2e-26 90.5 0.5 1.2e-25 89.7 0.5 1.4 1 0 0 1 1 1 1 HMG-box domain HMG_box PF00505.17 001097511.1_49824001_2 - 1e-05 25.7 0.1 2.7e-05 24.4 0.1 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box Insulin PF00049.16 001082026.1_37921001_1 - 1e-14 55.2 10.2 3.4e-13 50.3 4.8 2.8 2 1 0 2 2 2 1 Insulin/IGF/Relaxin family RRM_1 PF00076.20 001044728.1_29623001_1 - 9.4e-78 255.9 0.5 1.1e-21 76.3 0.1 4.1 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 001044728.1_29623001_1 - 1.1e-13 50.8 0.0 0.0001 21.8 0.0 3.3 2 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001044728.1_29623001_1 - 1.4e-09 37.6 0.0 0.00013 21.6 0.0 3.3 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_7 PF16367.3 001044728.1_29623001_1 - 7e-06 25.9 0.1 0.65 10.0 0.0 4.7 4 2 0 4 4 4 2 RNA recognition motif RRM_3 PF08777.9 001044728.1_29623001_1 - 6.9e-05 22.7 0.6 0.047 13.6 0.1 2.9 3 0 0 3 3 3 2 RNA binding motif Nup35_RRM_2 PF14605.4 001044728.1_29623001_1 - 0.00027 20.7 0.8 10 6.0 0.0 4.1 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif TC1 PF15063.4 001044728.1_29623001_1 - 0.001 18.8 0.0 0.054 13.2 0.0 2.7 3 0 0 3 3 3 1 Thyroid cancer protein 1 DUF4523 PF15023.4 001044728.1_29623001_1 - 0.052 13.2 0.0 4.7 6.9 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4523) SET_assoc PF11767.6 001044728.1_29623001_1 - 0.082 12.4 0.1 3.3 7.3 0.0 2.8 3 0 0 3 3 3 0 Histone lysine methyltransferase SET associated Sugar_tr PF00083.22 001044617.1_49824001_1 - 3e-28 98.8 7.2 3.9e-28 98.4 7.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001044617.1_49824001_1 - 1.8e-27 96.1 23.8 2.8e-27 95.4 23.8 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.4 001044617.1_49824001_1 - 0.00013 20.5 6.5 0.00013 20.5 6.5 2.6 2 1 1 3 3 3 2 MFS/sugar transport protein TRI12 PF06609.11 001044617.1_49824001_1 - 0.23 9.7 9.6 0.025 12.9 2.4 2.0 1 1 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) Peptidase_U4 PF03419.11 001044617.1_49824001_1 - 0.72 9.0 6.3 1.9 7.5 6.3 1.8 1 0 0 1 1 1 0 Sporulation factor SpoIIGA Pkinase_Tyr PF07714.15 001111071.1_39529001_2 - 6.6e-93 310.6 0.0 1.2e-92 309.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Sema PF01403.17 001111071.1_39529001_2 - 7.2e-59 199.5 3.1 1.1e-58 198.9 3.1 1.2 1 0 0 1 1 1 1 Sema domain Pkinase PF00069.23 001111071.1_39529001_2 - 8.8e-40 136.6 0.0 1.5e-39 135.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain TIG PF01833.22 001111071.1_39529001_2 - 4.6e-38 129.0 16.3 1.3e-13 50.6 0.9 4.7 4 0 0 4 4 4 4 IPT/TIG domain PSI PF01437.23 001111071.1_39529001_2 - 0.00013 22.3 16.3 0.00013 22.3 16.3 2.4 2 0 0 2 2 2 1 Plexin repeat Kinase-like PF14531.4 001111071.1_39529001_2 - 0.00029 20.1 0.0 0.0005 19.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Linker_histone PF00538.17 001111071.1_39529001_2 - 0.064 13.5 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 linker histone H1 and H5 family TGF_beta PF00019.18 001168763.1_40423001_1 - 2e-26 92.8 0.2 4e-26 91.8 0.2 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain HCO3_cotransp PF00955.19 001082030.1_37928001_2 - 8.5e-200 664.8 13.2 1.7e-120 403.2 4.9 2.1 1 1 1 2 2 2 2 HCO3- transporter family Band_3_cyto PF07565.11 001082030.1_37928001_2 - 3.1e-102 341.9 0.0 4.8e-102 341.2 0.0 1.3 1 0 0 1 1 1 1 Band 3 cytoplasmic domain wnt PF00110.17 001195319.1_39525001_1 - 2.2e-121 405.0 26.1 2.6e-121 404.7 26.1 1.1 1 0 0 1 1 1 1 wnt family NUDE_C PF04880.11 001082020.1_37925001_3 - 9.3e-47 159.6 0.9 9.3e-47 159.6 0.9 2.4 2 0 0 2 2 2 1 NUDE protein, C-terminal conserved region TPR_MLP1_2 PF07926.10 001082020.1_37925001_3 - 0.0013 18.6 5.6 0.0013 18.6 5.6 3.1 1 1 2 3 3 3 1 TPR/MLP1/MLP2-like protein PRKG1_interact PF15898.3 001082020.1_37925001_3 - 0.027 15.2 22.1 0.039 14.7 8.7 2.5 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain Golgin_A5 PF09787.7 001082020.1_37925001_3 - 0.16 11.3 24.4 0.26 10.6 24.4 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF1664 PF07889.10 001082020.1_37925001_3 - 0.29 11.0 7.8 0.11 12.4 4.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF2410 PF10307.7 001082020.1_37925001_3 - 0.45 10.2 7.3 1.8 8.2 7.0 1.8 1 1 1 2 2 2 0 Hypothetical protein (DUF2410) Rootletin PF15035.4 001082020.1_37925001_3 - 0.51 10.3 30.4 0.87 9.5 11.3 2.2 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion ATG16 PF08614.9 001082020.1_37925001_3 - 0.7 9.9 36.1 1.8 8.5 19.5 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) KxDL PF10241.7 001082020.1_37925001_3 - 4.8 7.4 12.8 0.92 9.7 5.1 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein Fzo_mitofusin PF04799.11 001082020.1_37925001_3 - 6.1 6.2 12.9 0.47 9.8 5.0 2.3 1 1 0 2 2 2 0 fzo-like conserved region CCDC92 PF14916.4 001082020.1_37925001_3 - 8 6.2 8.8 4.6 7.0 0.3 3.1 2 1 1 3 3 3 0 Coiled-coil domain of unknown function FA_desaturase PF00487.22 001112627.1_40423001_1 - 2e-33 116.2 31.5 2e-33 116.2 31.5 2.1 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.26 001112627.1_40423001_1 - 4.6e-21 74.6 0.1 1.4e-20 73.0 0.0 1.9 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain Voltage_CLC PF00654.18 001082074.1_37926001_1 - 9.3e-97 324.3 24.3 1.2e-96 324.0 20.3 2.1 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.26 001082074.1_37926001_1 - 7.9e-16 58.1 0.4 3.1e-09 37.0 0.0 3.3 3 0 0 3 3 3 2 CBS domain DUF2818 PF10993.6 001082074.1_37926001_1 - 0.72 10.3 5.6 55 4.3 0.1 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2818) Exo_endo_phos PF03372.21 001077513.1_39724001_1 - 6.8e-07 29.4 0.0 1e-06 28.8 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PDZ PF00595.22 001082151.2_37924001_2 - 8.5e-56 186.1 8.0 1.1e-13 51.2 0.5 4.2 4 0 0 4 4 4 4 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001082151.2_37924001_2 - 3.6e-29 100.8 8.3 2.3e-08 34.1 0.2 4.3 4 0 0 4 4 4 4 PDZ domain GRASP55_65 PF04495.12 001082151.2_37924001_2 - 6.8e-11 42.5 0.3 0.078 13.2 0.0 4.1 4 0 0 4 4 4 3 GRASP55/65 PDZ-like domain Tricorn_PDZ PF14685.4 001082151.2_37924001_2 - 2.1e-06 27.5 5.4 0.008 16.0 0.1 4.2 4 0 0 4 4 4 2 Tricorn protease PDZ domain DUF4265 PF14085.4 001082151.2_37924001_2 - 0.0001 22.1 1.3 0.44 10.4 0.1 3.6 4 0 0 4 4 4 2 Domain of unknown function (DUF4265) DUF3394 PF11874.6 001082151.2_37924001_2 - 0.017 14.6 0.6 7.9 6.0 0.0 3.7 3 2 0 3 3 3 0 Domain of unknown function (DUF3394) 7tm_1 PF00001.19 001099927.1_49823001_1 - 1.9e-65 220.7 6.5 2.9e-65 220.0 6.5 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001099927.1_49823001_1 - 2.6e-09 36.7 0.9 2.2e-08 33.7 0.9 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001099927.1_49823001_1 - 6.6e-07 29.2 1.3 1.2e-06 28.3 1.3 1.3 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001099927.1_49823001_1 - 0.00087 18.6 1.7 0.0012 18.1 1.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.7 001099927.1_49823001_1 - 0.019 14.2 1.7 0.037 13.2 1.7 1.4 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv PALP PF00291.23 001082082.2_37924001_2 - 8.7e-66 222.2 0.1 1.1e-65 221.9 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.26 001082082.2_37924001_2 - 6.7e-10 39.1 0.1 4.1e-07 30.2 0.0 2.9 3 0 0 3 3 3 2 CBS domain DUF1414 PF07208.9 001082082.2_37924001_2 - 0.084 12.8 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1414) AC_N PF16214.3 001082628.1_37929001_1 - 1.1e-241 802.1 0.0 1.1e-241 802.1 0.0 1.9 2 0 0 2 2 2 1 Adenylyl cyclase N-terminal extracellular and transmembrane region Guanylate_cyc PF00211.18 001082628.1_37929001_1 - 1.3e-121 402.9 3.1 1.8e-62 210.1 0.7 2.2 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain DUF1053 PF06327.12 001082628.1_37929001_1 - 1.6e-27 95.9 0.2 3.5e-27 94.8 0.2 1.6 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1053) HNOBA PF07701.12 001082628.1_37929001_1 - 0.0054 16.1 1.2 0.74 9.1 0.1 2.4 2 0 0 2 2 2 2 Heme NO binding associated DUF2339 PF10101.7 001082628.1_37929001_1 - 0.43 9.0 21.9 0.019 13.4 12.5 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2339) COX8 PF02285.13 001079925.1_39721001_1 - 3.7e-23 81.0 0.1 4.8e-23 80.6 0.1 1.2 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIII CSTF_C PF14304.4 001079925.1_39721001_1 - 0.016 14.6 0.1 0.024 14.1 0.1 1.3 1 0 0 1 1 1 0 Transcription termination and cleavage factor C-terminal zf-RanBP PF00641.16 001044582.1_49826001_2 - 1.4e-12 46.5 22.2 1.5e-06 27.2 3.7 2.7 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others DUF35_N PF12172.6 001044582.1_49826001_2 - 0.4 10.5 5.8 0.72 9.7 0.2 2.5 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Atg8 PF02991.14 001082142.1_37922001_2 - 7.1e-48 161.0 0.1 9.8e-48 160.5 0.1 1.2 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.11 001082142.1_37922001_2 - 1.6e-07 31.5 0.0 2.6e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 7tm_2 PF00002.22 001038662.1_29626001_1 - 1.6e-50 171.5 19.6 2.3e-50 171.1 19.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) EGF_CA PF07645.13 001038662.1_29626001_1 - 3.3e-49 164.7 61.5 3.3e-14 52.7 6.3 5.5 5 0 0 5 5 5 5 Calcium-binding EGF domain cEGF PF12662.5 001038662.1_29626001_1 - 6.1e-26 89.9 27.8 8.2e-07 28.7 0.3 5.7 5 0 0 5 5 5 5 Complement Clr-like EGF-like hEGF PF12661.5 001038662.1_29626001_1 - 3.3e-14 52.8 68.3 5.8e-05 23.5 6.2 7.1 7 0 0 7 7 7 5 Human growth factor-like EGF EGF_3 PF12947.5 001038662.1_29626001_1 - 6.1e-14 51.8 58.1 5e-05 23.3 2.5 6.6 6 0 0 6 6 6 4 EGF domain EGF_MSP1_1 PF12946.5 001038662.1_29626001_1 - 2.3e-13 49.8 47.0 0.0032 17.3 2.8 5.7 5 0 0 5 5 5 5 MSP1 EGF domain 1 GPS PF01825.19 001038662.1_29626001_1 - 1.2e-11 44.9 8.3 1.2e-11 44.9 8.3 4.9 6 0 0 6 6 3 1 GPCR proteolysis site, GPS, motif EGF PF00008.25 001038662.1_29626001_1 - 4.3e-11 42.8 67.9 1.8e-06 28.0 5.9 6.6 6 0 0 6 6 6 4 EGF-like domain FXa_inhibition PF14670.4 001038662.1_29626001_1 - 7.9e-05 22.7 65.2 0.019 15.1 5.3 6.3 6 0 0 6 6 5 4 Coagulation Factor Xa inhibitory site Plasmod_Pvs28 PF06247.9 001038662.1_29626001_1 - 0.00016 21.8 47.4 0.019 15.1 3.5 6.0 4 1 1 5 5 5 3 Pvs28 EGF domain Comm PF15957.3 001038662.1_29626001_1 - 0.034 14.3 0.1 1.4 9.2 0.0 2.8 2 0 0 2 2 2 0 Commissureless DUF1539 PF07560.9 001038662.1_29626001_1 - 0.12 12.3 1.9 4.5 7.2 0.1 3.1 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1539) EGF_2 PF07974.11 001038662.1_29626001_1 - 2.7 8.3 59.5 0.31 11.3 5.1 5.9 5 0 0 5 5 5 0 EGF-like domain Insulin PF00049.16 001118912.1_39722001_1 - 4.6e-22 78.7 1.6 7.6e-22 78.0 1.6 1.4 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family Ins_beta PF03488.12 001118912.1_39722001_1 - 0.11 12.4 3.3 3.2 7.7 0.1 2.2 2 0 0 2 2 2 0 Nematode insulin-related peptide beta type fn3 PF00041.19 001038615.1_45729001_1 - 1.8e-39 133.8 10.8 2.6e-12 46.8 0.0 5.7 4 1 1 5 5 5 5 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 001038615.1_45729001_1 - 1.7e-12 47.6 14.9 0.0011 19.3 0.1 5.2 5 1 0 5 5 5 3 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 001038615.1_45729001_1 - 7.3e-07 29.3 0.0 0.33 11.2 0.0 4.3 4 0 0 4 4 4 2 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.7 001038615.1_45729001_1 - 3.9e-05 23.9 0.1 0.6 10.5 0.0 4.3 4 0 0 4 4 4 2 Uncharacterised conserved protein (DUF2369) PhoD_N PF16655.3 001038615.1_45729001_1 - 0.007 16.7 0.0 5.5 7.5 0.0 3.1 2 0 0 2 2 2 2 PhoD-like phosphatase, N-terminal domain Sterile PF03015.17 001038615.1_45729001_1 - 0.12 12.5 0.0 17 5.6 0.0 2.3 2 0 0 2 2 2 0 Male sterility protein Filament PF00038.19 001101007.1_45725001_1 - 4e-113 378.0 34.0 4.7e-113 377.8 34.0 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.3 001101007.1_45725001_1 - 2.9e-31 108.7 40.2 2.9e-31 108.7 40.2 2.5 2 1 0 2 2 2 1 Keratin type II head TPR_MLP1_2 PF07926.10 001101007.1_45725001_1 - 2.9e-06 27.3 29.1 0.00079 19.4 2.4 3.5 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.7 001101007.1_45725001_1 - 3.4e-05 23.7 22.9 0.001 19.0 4.4 3.5 1 1 2 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.4 001101007.1_45725001_1 - 0.0014 17.2 18.4 0.0019 16.8 17.8 1.6 1 1 0 1 1 1 1 AAA domain Reo_sigmaC PF04582.10 001101007.1_45725001_1 - 0.0035 16.6 7.4 0.036 13.4 0.8 2.7 1 1 0 2 2 2 1 Reovirus sigma C capsid protein Virulence_fact PF13769.4 001101007.1_45725001_1 - 0.0045 17.0 5.3 0.12 12.4 0.1 3.2 2 1 1 3 3 3 1 Virulence factor Alanine_zipper PF11839.6 001101007.1_45725001_1 - 0.0052 16.9 3.0 0.0052 16.9 3.0 2.3 2 0 0 2 2 2 1 Alanine-zipper, major outer membrane lipoprotein Tropomyosin_1 PF12718.5 001101007.1_45725001_1 - 0.006 16.6 7.1 0.006 16.6 7.1 3.6 1 1 3 4 4 4 1 Tropomyosin like Spc7 PF08317.9 001101007.1_45725001_1 - 0.0068 15.2 29.7 0.03 13.1 13.3 3.1 1 1 2 3 3 3 2 Spc7 kinetochore protein IncA PF04156.12 001101007.1_45725001_1 - 0.011 15.5 6.8 0.011 15.5 6.8 3.3 1 1 1 3 3 3 0 IncA protein DASH_Duo1 PF08651.8 001101007.1_45725001_1 - 0.016 14.8 6.5 0.53 10.0 1.6 3.8 3 0 0 3 3 3 0 DASH complex subunit Duo1 Baculo_PEP_C PF04513.10 001101007.1_45725001_1 - 0.032 14.1 17.5 0.14 12.1 0.5 3.9 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus ATG16 PF08614.9 001101007.1_45725001_1 - 0.037 14.1 25.9 0.014 15.5 7.0 2.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) ADIP PF11559.6 001101007.1_45725001_1 - 0.047 13.6 24.7 0.018 15.0 4.7 3.9 2 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding UPF0184 PF03670.11 001101007.1_45725001_1 - 0.056 13.7 0.3 0.27 11.5 0.1 2.2 2 0 0 2 2 1 0 Uncharacterised protein family (UPF0184) TSC22 PF01166.16 001101007.1_45725001_1 - 0.057 13.6 8.1 6.9 6.9 0.1 4.2 3 1 1 4 4 4 0 TSC-22/dip/bun family mRNA_decap_C PF16741.3 001101007.1_45725001_1 - 0.067 12.4 0.1 5.2 6.3 0.0 2.5 2 0 0 2 2 2 0 mRNA-decapping enzyme C-terminus Golgin_A5 PF09787.7 001101007.1_45725001_1 - 0.12 11.7 23.7 0.17 11.2 7.4 2.9 1 1 2 3 3 3 0 Golgin subfamily A member 5 TMF_TATA_bd PF12325.6 001101007.1_45725001_1 - 0.14 12.2 22.4 0.44 10.6 4.7 3.9 2 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding DUF883 PF05957.11 001101007.1_45725001_1 - 0.16 12.4 16.5 0.31 11.5 3.9 4.2 2 1 3 5 5 4 0 Bacterial protein of unknown function (DUF883) MCC-bdg_PDZ PF10506.7 001101007.1_45725001_1 - 0.17 11.8 2.9 0.56 10.1 2.9 1.9 1 0 0 1 1 1 0 PDZ domain of MCC-2 bdg protein for Usher syndrome TraC PF07820.10 001101007.1_45725001_1 - 0.31 11.3 6.9 4.4 7.6 4.1 2.8 2 0 0 2 2 2 0 TraC-like protein DUF4407 PF14362.4 001101007.1_45725001_1 - 0.35 10.1 23.7 1.6 7.9 4.8 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Med9 PF07544.11 001101007.1_45725001_1 - 0.47 10.4 6.3 0.82 9.7 3.6 2.6 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 COG5 PF10392.7 001101007.1_45725001_1 - 0.57 10.2 8.8 0.19 11.8 2.9 2.6 1 1 1 2 2 2 0 Golgi transport complex subunit 5 Jnk-SapK_ap_N PF09744.7 001101007.1_45725001_1 - 0.88 9.7 24.8 0.25 11.4 3.2 3.5 1 1 1 3 3 3 0 JNK_SAPK-associated protein-1 DUF5082 PF16888.3 001101007.1_45725001_1 - 1.3 9.2 24.5 2.4 8.4 6.4 4.4 1 1 2 4 4 4 0 Domain of unknown function (DUF5082) OAD_gamma PF04277.11 001101007.1_45725001_1 - 2 8.9 4.2 0.58 10.6 1.0 1.8 2 0 0 2 2 1 0 Oxaloacetate decarboxylase, gamma chain DUF2746 PF10874.6 001101007.1_45725001_1 - 2 8.7 4.4 1.4 9.2 0.3 2.6 3 0 0 3 3 2 0 Protein of unknown function (DUF2746) Laminin_II PF06009.10 001101007.1_45725001_1 - 2 8.3 15.5 3.5 7.5 1.8 3.6 2 2 1 3 3 3 0 Laminin Domain II APG6 PF04111.10 001101007.1_45725001_1 - 2.4 7.3 28.5 0.44 9.8 6.1 2.9 1 1 2 3 3 3 0 Autophagy protein Apg6 PRKG1_interact PF15898.3 001101007.1_45725001_1 - 2.7 8.8 21.0 1.4 9.8 4.7 3.7 2 1 2 4 4 3 0 cGMP-dependent protein kinase interacting domain DUF1192 PF06698.9 001101007.1_45725001_1 - 3 7.9 12.0 0.074 13.0 1.6 3.4 4 1 0 4 4 2 0 Protein of unknown function (DUF1192) Ax_dynein_light PF10211.7 001101007.1_45725001_1 - 3.6 7.3 27.5 0.79 9.5 5.4 3.5 1 1 2 3 3 3 0 Axonemal dynein light chain Fib_alpha PF08702.8 001101007.1_45725001_1 - 3.7 7.6 23.4 1.8 8.6 2.4 3.7 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family DUF948 PF06103.9 001101007.1_45725001_1 - 4.4 7.5 10.2 2.2 8.5 0.6 3.9 3 2 0 4 4 3 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.10 001101007.1_45725001_1 - 4.6 7.1 15.9 1 9.2 2.0 4.0 3 1 0 4 4 4 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.7 001101007.1_45725001_1 - 4.8 7.4 20.0 2.3 8.5 1.1 4.4 2 2 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1451 PF07295.9 001101007.1_45725001_1 - 5.2 7.0 12.9 2.9 7.8 3.6 2.5 2 0 0 2 2 2 0 Zinc-ribbon containing domain DUF4988 PF16378.3 001101007.1_45725001_1 - 5.6 6.4 7.4 6.9 6.1 0.3 3.0 3 0 0 3 3 3 0 Domain of unknown function TMPIT PF07851.11 001101007.1_45725001_1 - 5.7 6.0 16.6 0.33 10.0 3.4 2.6 1 1 2 3 3 3 0 TMPIT-like protein FlaC_arch PF05377.9 001101007.1_45725001_1 - 7.1 7.0 14.2 2.2 8.6 0.6 4.9 5 1 1 6 6 5 0 Flagella accessory protein C (FlaC) Atg14 PF10186.7 001101007.1_45725001_1 - 8.1 5.3 19.7 0.6 9.0 11.6 2.2 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Wtap PF17098.3 001101007.1_45725001_1 - 8.5 6.2 18.5 0.91 9.3 3.2 3.5 2 1 1 3 3 3 0 WTAP/Mum2p family LPP PF04728.11 001101007.1_45725001_1 - 9 6.6 10.8 0.34 11.2 0.3 3.7 5 0 0 5 5 3 0 Lipoprotein leucine-zipper ApoLp-III PF07464.9 001101007.1_45725001_1 - 9.9 6.1 17.8 0.056 13.4 2.6 3.2 2 1 1 3 3 3 0 Apolipophorin-III precursor (apoLp-III) CHDCT2 PF08074.9 001101007.1_45725001_1 - 10 6.2 12.2 5.6 7.0 0.3 2.8 1 1 0 3 3 3 0 CHDCT2 (NUC038) domain Pkinase PF00069.23 001071822.1_39729001_1 - 1.3e-70 237.7 0.0 1.9e-70 237.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001071822.1_39729001_1 - 2.3e-38 131.8 0.0 3.4e-38 131.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001071822.1_39729001_1 - 5.7e-11 42.1 0.0 9.1e-11 41.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 001071822.1_39729001_1 - 5.5e-06 25.7 0.1 1e-05 24.9 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 001071822.1_39729001_1 - 0.00012 21.6 0.1 0.00021 20.8 0.1 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.21 001071822.1_39729001_1 - 0.00027 20.8 0.0 0.00052 19.9 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1648 PF07853.9 001071822.1_39729001_3 - 0.05 13.1 0.0 0.13 11.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1648) Peptidase_C2 PF00648.19 001097443.1_49826001_3 - 6e-49 166.5 0.6 2.3e-47 161.3 0.1 2.3 2 0 0 2 2 2 1 Calpain family cysteine protease MIT PF04212.16 001097443.1_49826001_3 - 7.5e-23 80.3 13.2 9.9e-13 47.8 3.8 2.3 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain Calpain_III PF01067.20 001097443.1_49826001_3 - 2.4e-11 43.9 2.8 3e-07 30.7 0.9 3.9 3 1 0 3 3 3 2 Calpain large subunit, domain III TPR_1 PF00515.26 001097443.1_49826001_3 - 0.041 13.6 1.1 6.7 6.6 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.15 001097443.1_49826001_3 - 0.16 12.0 7.0 1.1 9.4 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat T2SSF PF00482.21 001097443.1_49826001_3 - 0.81 9.5 2.0 0.55 10.1 0.2 1.6 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F TPR_12 PF13424.4 001097443.1_49826001_3 - 3 8.1 5.7 1.1 9.4 1.3 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat p450 PF00067.20 001093789.1_39524001_1 - 4.1e-125 418.0 0.7 4.7e-125 417.8 0.7 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ig_2 PF13895.4 001112647.1_40422001_1 - 3.1e-21 75.3 1.5 4.2e-11 42.9 0.3 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001112647.1_40422001_1 - 8.5e-16 58.2 0.4 4.1e-08 33.6 0.2 2.6 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001112647.1_40422001_1 - 6.3e-10 39.0 1.9 0.00086 19.3 0.1 2.8 2 1 0 2 2 2 2 Immunoglobulin domain Ig_4 PF16680.3 001112647.1_40422001_1 - 1.6e-07 31.4 0.3 0.0094 16.1 0.0 2.3 2 0 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain I-set PF07679.14 001112647.1_40422001_1 - 1.2e-05 25.2 3.6 0.019 14.9 0.1 3.3 3 2 0 3 3 3 2 Immunoglobulin I-set domain V-set PF07686.15 001112647.1_40422001_1 - 9.1e-05 22.5 6.9 0.14 12.2 0.1 4.1 3 2 0 3 3 3 2 Immunoglobulin V-set domain Ig_5 PF16681.3 001112647.1_40422001_1 - 0.0013 19.0 4.0 0.014 15.7 0.0 2.6 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 001112647.1_40422001_1 - 0.072 13.0 0.1 3.7 7.5 0.0 2.9 2 1 1 3 3 3 0 Izumo-like Immunoglobulin domain WD40 PF00400.30 001082178.1_37923001_2 - 4e-24 84.3 0.9 4.9e-06 27.0 1.6 5.6 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001082178.1_37923001_2 - 3.7e-13 49.5 0.0 0.0018 18.4 0.0 5.0 3 2 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 001082178.1_37923001_2 - 0.00015 20.7 0.2 0.073 11.9 0.0 3.0 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein p450 PF00067.20 001040622.1_39724001_2 - 7.6e-132 440.2 0.0 8.7e-132 440.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Lipocalin PF00061.21 001082230.1_37924001_1 - 3.4e-24 85.5 2.3 4.4e-24 85.2 2.3 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 001082230.1_37924001_1 - 0.013 15.3 1.5 0.019 14.8 1.5 1.2 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family Ammonium_transp PF00909.19 001082136.1_37924001_1 - 5.7e-74 249.1 17.9 7e-74 248.8 17.9 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family 7tm_2 PF00002.22 001082028.1_37923001_3 - 6.1e-93 310.5 15.5 6.1e-93 310.5 15.5 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 001082028.1_37923001_3 - 1.4e-19 70.0 1.8 4e-19 68.5 1.8 1.8 1 0 0 1 1 1 1 Hormone receptor domain Crystallin PF00525.16 001082407.1_37922001_3 - 5.4e-30 103.3 7.2 9.2e-30 102.5 7.2 1.4 1 0 0 1 1 1 1 Alpha crystallin A chain, N terminal HSP20 PF00011.19 001082407.1_37922001_3 - 2.1e-25 88.7 0.0 2.6e-25 88.4 0.0 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Calc_CGRP_IAPP PF00214.17 001099939.1_49822001_2 - 7.1e-05 23.0 0.0 0.0001 22.5 0.0 1.3 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family SIM_C PF06621.10 001081488.1_39725001_1 - 3.9e-115 384.8 17.0 6e-115 384.2 17.0 1.3 1 0 0 1 1 1 1 Single-minded protein C-terminus PAS_3 PF08447.10 001081488.1_39725001_1 - 1.1e-25 89.6 2.4 9.1e-19 67.4 0.0 3.0 3 0 0 3 3 3 2 PAS fold PAS_11 PF14598.4 001081488.1_39725001_1 - 1.1e-19 70.5 1.8 2.7e-14 53.1 0.1 2.8 3 0 0 3 3 3 2 PAS domain PAS PF00989.23 001081488.1_39725001_1 - 3.4e-18 65.6 0.0 6.3e-12 45.4 0.0 2.5 2 0 0 2 2 2 2 PAS fold HLH PF00010.24 001081488.1_39725001_1 - 1.8e-06 27.7 0.8 2.9e-05 23.8 0.8 2.4 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.5 001081488.1_39725001_1 - 4.2e-05 23.6 0.0 0.014 15.5 0.0 2.4 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.8 001081488.1_39725001_1 - 0.00054 20.1 0.0 0.027 14.6 0.0 2.6 2 0 0 2 2 2 1 PAS fold MHC_I_3 PF16497.3 001071804.1_39723001_1 - 1.7e-94 314.7 4.4 1.7e-94 314.7 4.4 1.4 2 0 0 2 2 2 1 MHC-I family domain C1-set PF07654.13 001071804.1_39723001_1 - 2.1e-11 44.0 0.0 6.6e-11 42.4 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001071804.1_39723001_1 - 2e-06 27.4 0.1 2.9e-06 26.8 0.1 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Ig_3 PF13927.4 001071804.1_39723001_1 - 0.0018 18.7 0.2 0.4 11.2 0.1 3.2 2 1 1 3 3 3 1 Immunoglobulin domain Serpin PF00079.18 001082329.1_37925001_1 - 1.1e-106 357.1 5.0 1.5e-106 356.7 5.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) zf-RING_5 PF14634.4 001082329.1_37925001_3 - 0.36 10.7 13.3 0.056 13.3 1.6 2.8 2 0 0 2 2 2 0 zinc-RING finger domain Porin_3 PF01459.20 001082076.1_37922001_1 - 4.3e-85 285.3 6.2 4.9e-85 285.1 6.2 1.0 1 0 0 1 1 1 1 Eukaryotic porin PAP2 PF01569.19 001168983.1_40422001_1 - 3.3e-19 68.9 6.2 9.2e-19 67.5 6.2 1.8 1 1 0 1 1 1 1 PAP2 superfamily UbiA PF01040.16 001168983.1_40422001_1 - 0.0014 17.8 8.2 0.0014 17.8 8.2 1.9 2 0 0 2 2 2 1 UbiA prenyltransferase family Lipase_GDSL PF00657.20 001101708.1_37929001_1 - 2.7e-88 295.1 0.0 2.3e-31 109.2 0.0 3.7 4 0 0 4 4 4 3 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.4 001101708.1_37929001_1 - 7.7e-23 81.7 8.0 1.9e-07 31.5 0.0 5.2 3 3 0 3 3 3 3 GDSL-like Lipase/Acylhydrolase family DUF2493 PF10686.7 001101708.1_37929001_1 - 0.049 13.4 0.2 16 5.4 0.0 4.2 5 0 0 5 5 5 0 Protein of unknown function (DUF2493) RecR PF02132.13 001101708.1_37929001_1 - 0.52 9.8 4.1 16 5.0 0.0 3.8 3 0 0 3 3 3 0 RecR protein GST_N PF02798.18 001082252.1_37923001_1 - 8.9e-20 70.7 0.0 2.1e-19 69.5 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 001082252.1_37923001_1 - 5e-17 61.8 0.0 9.8e-17 60.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 001082252.1_37923001_1 - 1.7e-15 56.9 0.0 3.2e-15 56.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.2 001082252.1_37923001_1 - 0.0058 16.3 0.2 0.016 14.8 0.2 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 001082252.1_37923001_1 - 0.0069 16.2 0.1 0.02 14.7 0.1 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 001082252.1_37923001_1 - 0.014 15.6 0.0 0.034 14.4 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain ArgK PF03308.14 001082662.1_37923001_1 - 0.0022 16.9 0.0 0.0033 16.3 0.0 1.1 1 0 0 1 1 1 1 ArgK protein ArgK PF03308.14 001082662.1_37923001_2 - 2.1e-52 177.6 0.0 6.2e-52 176.1 0.0 1.7 1 1 0 1 1 1 1 ArgK protein cobW PF02492.17 001082662.1_37923001_2 - 0.014 14.9 0.0 0.24 10.8 0.0 2.2 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.4 001082662.1_37923001_2 - 0.064 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain ArgK PF03308.14 001082662.1_37923001_3 - 6.6e-06 25.2 0.0 8.7e-06 24.8 0.0 1.1 1 0 0 1 1 1 1 ArgK protein Linker_histone PF00538.17 001101066.1_06528001_2 - 2.1e-22 79.1 0.6 4.1e-22 78.2 0.6 1.5 1 0 0 1 1 1 1 linker histone H1 and H5 family MHC_I PF00129.16 001045498.1_39723001_1 - 1.2e-93 311.6 0.6 1.6e-93 311.1 0.6 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001045498.1_39723001_1 - 4.3e-17 62.2 0.0 9.7e-17 61.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.3 001045498.1_39723001_1 - 2.8e-06 26.8 0.0 3.9e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain C2-set_2 PF08205.10 001045498.1_39723001_1 - 3.4e-05 23.7 0.1 6.5e-05 22.8 0.1 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001045498.1_39723001_1 - 0.00048 20.1 0.4 0.0011 18.9 0.1 1.8 2 0 0 2 2 2 1 Immunoglobulin domain MHC_I_C PF06623.9 001045498.1_39723001_1 - 0.00082 19.1 6.2 0.0021 17.8 2.8 2.3 2 0 0 2 2 2 1 MHC_I C-terminus HTH_28 PF13518.4 001045498.1_39723001_1 - 0.052 13.6 0.3 5.7 7.0 0.1 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain ubiquitin PF00240.21 001009117.2_39722001_2 - 1.7e-104 341.5 10.1 4.7e-34 115.8 0.3 3.0 3 0 0 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.6 001009117.2_39722001_2 - 1.2e-50 169.1 10.7 3.8e-16 58.5 0.4 3.0 3 0 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 001009117.2_39722001_2 - 4.6e-20 71.7 4.3 2.7e-05 24.4 0.2 4.4 3 3 0 3 3 3 3 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 001009117.2_39722001_2 - 3.5e-11 43.1 1.1 0.061 13.3 0.0 3.8 3 3 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 001009117.2_39722001_2 - 6.9e-09 36.1 0.1 0.47 10.9 0.0 3.2 1 1 2 3 3 3 3 DUF2407 ubiquitin-like domain Telomere_Sde2 PF13019.4 001009117.2_39722001_2 - 3.6e-06 26.8 0.0 2.2 8.0 0.0 3.1 1 1 2 3 3 3 3 Telomere stability and silencing DUF2870 PF11069.6 001009117.2_39722001_2 - 5.6e-05 23.3 0.0 11 6.3 0.0 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2870) RBD PF02196.13 001009117.2_39722001_2 - 0.00054 19.9 0.0 19 5.3 0.0 3.4 3 0 0 3 3 3 0 Raf-like Ras-binding domain PI3K_rbd PF00794.16 001009117.2_39722001_2 - 0.00087 19.3 0.8 11 6.1 0.1 3.5 3 0 0 3 3 3 0 PI3-kinase family, ras-binding domain Methyltrans_RNA PF04452.12 001009117.2_39722001_2 - 0.0013 18.0 0.1 1.5 7.9 0.0 2.3 2 0 0 2 2 2 2 RNA methyltransferase FERM_f0 PF16511.3 001009117.2_39722001_2 - 0.0014 18.7 8.2 25 5.1 0.2 5.6 3 3 0 3 3 3 0 N-terminal or F0 domain of Talin-head FERM FlgD_ig PF13860.4 001009117.2_39722001_2 - 0.0035 17.0 1.4 24 4.7 0.0 3.4 3 0 0 3 3 3 0 FlgD Ig-like domain DUF3861 PF12977.5 001009117.2_39722001_2 - 0.0042 17.1 0.4 34 4.6 0.0 3.2 3 0 0 3 3 3 0 Domain of Unknown Function with PDB structure (DUF3861) DUF969 PF06149.10 001009117.2_39722001_2 - 0.0056 16.0 0.0 12 5.1 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF969) TraK PF06586.9 001009117.2_39722001_2 - 0.066 12.7 0.2 53 3.2 0.0 3.0 3 0 0 3 3 3 0 TraK protein CorA PF01544.16 001009117.2_39722001_2 - 0.11 11.7 0.2 60 2.7 0.0 3.0 3 0 0 3 3 3 0 CorA-like Mg2+ transporter protein GDYXXLXY PF14345.4 001009117.2_39722001_2 - 0.12 12.1 0.1 1e+02 2.5 0.0 3.2 3 0 0 3 3 3 0 GDYXXLXY protein ORF11CD3 PF10549.7 001009117.2_39722001_2 - 0.13 12.2 0.0 74 3.4 0.0 3.5 3 0 0 3 3 3 0 ORF11CD3 domain ProRS-C_2 PF09181.8 001009117.2_39722001_2 - 0.16 11.9 1.1 1e+02 3.0 0.0 3.1 3 0 0 3 3 3 0 Prolyl-tRNA synthetase, C-terminal BC10 PF06726.10 001009117.2_39722001_3 - 4.6e-05 23.4 1.1 2.7 8.2 0.0 3.4 3 0 0 3 3 3 3 Bladder cancer-related protein BC10 Glycos_transf_2 PF00535.24 001101820.1_49822001_1 - 8.5e-39 133.0 0.0 1e-38 132.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.4 001101820.1_49822001_1 - 3.7e-11 43.3 0.0 8.1e-11 42.1 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.7 001101820.1_49822001_1 - 6.3e-05 22.4 0.0 8.6e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.4 001101820.1_49822001_1 - 0.00023 20.6 0.0 0.00041 19.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.4 001101820.1_49822001_1 - 0.003 17.9 0.0 0.0063 16.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 RRM_1 PF00076.20 001082079.1_37923001_2 - 9.2e-35 118.2 0.1 1.4e-16 59.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 001082079.1_37923001_2 - 3.5e-09 36.2 0.2 4.5e-05 22.9 0.1 2.4 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.21 001082079.1_37923001_2 - 1.2e-07 31.3 3.0 2.5e-07 30.3 3.0 1.6 1 0 0 1 1 1 1 Zinc knuckle RRM_7 PF16367.3 001082079.1_37923001_2 - 3.7e-06 26.8 0.0 0.0096 15.9 0.0 2.6 2 1 0 2 2 2 2 RNA recognition motif RRM_occluded PF16842.3 001082079.1_37923001_2 - 7.4e-05 22.4 0.0 0.013 15.2 0.0 2.4 2 0 0 2 2 2 1 Occluded RNA-recognition motif Calcipressin PF04847.10 001082079.1_37923001_2 - 0.0013 18.4 0.3 1.8 8.2 0.0 2.5 2 1 1 3 3 3 2 Calcipressin zf-CCHC_3 PF13917.4 001082079.1_37923001_2 - 0.0021 17.8 0.7 0.0048 16.7 0.7 1.5 1 0 0 1 1 1 1 Zinc knuckle DbpA PF03880.13 001082079.1_37923001_2 - 0.0061 16.4 0.1 4.8 7.1 0.0 2.3 2 0 0 2 2 2 2 DbpA RNA binding domain zf-CCHC_2 PF13696.4 001082079.1_37923001_2 - 0.017 14.8 2.7 0.031 14.0 2.7 1.4 1 0 0 1 1 1 0 Zinc knuckle RNA_bind PF08675.9 001082079.1_37923001_2 - 0.018 14.9 0.0 2.4 8.1 0.0 2.5 2 0 0 2 2 2 0 RNA binding domain zf-CCHC_5 PF14787.4 001082079.1_37923001_2 - 0.039 13.5 2.7 0.11 12.1 2.7 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger CortBP2 PF09727.7 001195311.1_39529001_3 - 5e-39 134.1 40.7 2.5e-32 112.2 1.8 3.4 2 1 1 3 3 3 3 Cortactin-binding protein-2 Ank_2 PF12796.5 001195311.1_39529001_3 - 1.2e-38 131.4 7.9 6.8e-18 64.9 3.9 3.7 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001195311.1_39529001_3 - 3.3e-38 129.5 11.3 1.3e-12 47.8 0.3 5.2 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.4 001195311.1_39529001_3 - 6.1e-24 83.6 9.8 3.8e-08 33.4 0.1 5.8 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.28 001195311.1_39529001_3 - 2.4e-23 81.3 10.7 4.7e-05 23.5 0.0 6.3 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.4 001195311.1_39529001_3 - 1.1e-20 71.4 4.2 0.0016 18.6 0.0 7.0 6 0 0 6 6 6 6 Ankyrin repeat CALCOCO1 PF07888.9 001195311.1_39529001_3 - 0.2 10.0 27.5 0.35 9.2 27.5 1.3 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spc7 PF08317.9 001195311.1_39529001_3 - 1.2 7.8 31.9 2.5 6.8 31.9 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF2347 PF09804.7 001195311.1_39529001_3 - 4 6.8 7.7 7.7 5.9 7.7 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) DUF4407 PF14362.4 001195311.1_39529001_3 - 4.5 6.4 14.8 10 5.2 14.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SCAN PF02023.15 001081480.1_39722001_1 - 7.1e-27 92.9 1.4 9.9e-27 92.5 1.4 1.2 1 0 0 1 1 1 1 SCAN domain Dsl1_C PF11989.6 001081480.1_39722001_1 - 0.19 10.9 0.0 0.24 10.6 0.0 1.0 1 0 0 1 1 1 0 Retrograde transport protein Dsl1 C terminal PAS_3 PF08447.10 001082206.1_37925001_3 - 6.1e-24 84.0 0.0 9.6e-18 64.1 0.0 2.7 2 0 0 2 2 2 2 PAS fold PAS PF00989.23 001082206.1_37925001_3 - 5.2e-23 81.1 0.0 6.4e-15 55.0 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.4 001082206.1_37925001_3 - 7.5e-22 77.5 0.5 2.2e-19 69.5 0.2 2.8 2 1 1 3 3 3 1 PAS domain HLH PF00010.24 001082206.1_37925001_3 - 5.1e-15 55.0 1.2 1.2e-14 53.9 1.2 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.5 001082206.1_37925001_3 - 1.3e-09 38.1 0.0 1.8e-06 28.0 0.0 2.7 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.8 001082206.1_37925001_3 - 0.0028 17.7 0.0 0.89 9.7 0.0 2.5 2 0 0 2 2 2 1 PAS fold PAS_2 PF08446.9 001082206.1_37925001_3 - 0.11 13.0 0.0 2.9 8.5 0.0 2.8 3 0 0 3 3 3 0 PAS fold PRAS PF15798.3 001082206.1_37925001_3 - 0.14 12.5 0.2 0.14 12.5 0.2 2.1 2 0 0 2 2 2 0 Proline-rich AKT1 substrate 1 V-set PF07686.15 001042643.1_29623001_1 - 1.1e-17 64.0 0.4 2.1e-07 31.0 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.4 001042643.1_29623001_1 - 1.1e-12 48.2 0.2 1.1e-05 25.8 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001042643.1_29623001_1 - 9.2e-09 35.4 2.8 0.00064 19.9 0.4 3.7 2 2 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001042643.1_29623001_1 - 1.8e-08 34.2 0.1 0.0023 17.8 0.1 2.8 2 1 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.23 001042643.1_29623001_1 - 7.5e-07 29.1 0.7 0.033 14.2 0.3 3.0 2 2 0 2 2 2 2 Immunoglobulin domain Izumo-Ig PF16706.3 001042643.1_29623001_1 - 8e-05 22.5 0.0 0.038 13.9 0.0 2.9 2 1 0 2 2 2 1 Izumo-like Immunoglobulin domain Ig_5 PF16681.3 001042643.1_29623001_1 - 0.00044 20.5 0.2 5.1 7.5 0.0 3.3 3 0 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain RCR PF12273.6 001042643.1_29623001_1 - 0.0049 17.4 0.3 0.29 11.7 0.0 2.3 2 0 0 2 2 2 1 Chitin synthesis regulation, resistance to Congo red DUF1443 PF07280.9 001042643.1_29623001_1 - 0.014 15.0 1.0 0.025 14.2 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1443) ResB PF05140.12 001042643.1_29623001_1 - 0.11 11.0 0.0 0.16 10.5 0.0 1.2 1 0 0 1 1 1 0 ResB-like family DUF1498 PF07385.10 001042643.1_29623001_1 - 0.16 11.1 0.0 0.28 10.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1498) Peptidase_M14 PF00246.22 001098559.1_39725001_2 - 6.1e-82 275.5 0.0 7.5e-82 275.2 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.4 001098559.1_39725001_2 - 1e-15 57.6 0.0 1.6e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.4 001098559.1_39725001_2 - 3.7e-06 26.7 0.0 5.9e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 CarboxypepD_reg-like domain AstE_AspA PF04952.12 001098559.1_39725001_2 - 0.048 12.6 0.0 0.16 10.9 0.0 1.7 1 1 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family GAS PF13851.4 029372.2_32923001_1 - 0.0059 15.9 12.4 0.0059 15.9 12.4 2.7 1 1 2 3 3 3 1 Growth-arrest specific micro-tubule binding Fzo_mitofusin PF04799.11 029372.2_32923001_1 - 0.014 14.8 4.9 0.014 14.8 4.9 3.0 2 1 0 3 3 3 0 fzo-like conserved region DUF1192 PF06698.9 029372.2_32923001_1 - 0.1 12.5 3.1 1.1 9.2 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Nod1 PF17114.3 029372.2_32923001_1 - 0.38 10.8 6.9 5.5 7.0 0.9 2.5 2 1 1 3 3 3 0 Gef2-related medial cortical node protein Nod1 Lectin_N PF03954.12 029372.2_32923001_1 - 0.51 9.9 9.3 1.2 8.8 1.9 2.5 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain TPR_MLP1_2 PF07926.10 029372.2_32923001_1 - 1.3 8.9 27.3 0.024 14.6 13.9 2.8 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein NPV_P10 PF05531.10 029372.2_32923001_1 - 2 8.8 5.9 7.9 6.9 0.7 2.9 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Bcr-Abl_Oligo PF09036.8 029372.2_32923001_1 - 2.4 8.1 9.3 0.15 12.0 0.9 3.1 2 2 1 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain GIT_CC PF16559.3 029372.2_32923001_1 - 2.6 8.0 13.7 0.058 13.3 2.9 3.3 3 2 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF745 PF05335.11 029372.2_32923001_1 - 3.5 7.2 12.8 0.075 12.6 3.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF745) CortBP2 PF09727.7 001168715.1_40429001_3 - 3.8e-39 134.5 40.6 3.8e-32 111.6 1.5 3.4 2 1 1 3 3 3 3 Cortactin-binding protein-2 Ank_2 PF12796.5 001168715.1_40429001_3 - 6.6e-37 125.8 7.5 3e-18 66.1 3.3 3.6 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001168715.1_40429001_3 - 7.4e-35 118.7 9.4 2.5e-12 46.9 0.2 5.4 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.28 001168715.1_40429001_3 - 6.8e-23 79.9 5.3 0.00026 21.2 0.0 6.2 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.4 001168715.1_40429001_3 - 3.9e-22 77.8 9.2 2.8e-06 27.4 0.1 5.7 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.4 001168715.1_40429001_3 - 4.1e-18 63.5 4.4 0.022 15.1 0.0 7.0 6 0 0 6 6 6 5 Ankyrin repeat CALCOCO1 PF07888.9 001168715.1_40429001_3 - 0.12 10.8 26.6 0.22 9.9 26.6 1.3 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spc7 PF08317.9 001168715.1_40429001_3 - 0.98 8.1 33.1 2.2 7.0 33.1 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.4 001168715.1_40429001_3 - 3.2 6.9 16.5 6.3 5.9 16.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Caveolin PF01146.15 001111072.1_37926001_2 - 6.3e-59 197.6 2.3 9.5e-59 197.0 2.3 1.3 1 0 0 1 1 1 1 Caveolin p450 PF00067.20 001075100.2_39524001_1 - 4.4e-113 378.3 0.0 5.1e-113 378.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ACOX PF01756.17 001082763.1_37925001_2 - 6.1e-62 208.3 0.8 3.6e-61 205.7 0.2 2.1 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.4 001082763.1_37925001_2 - 1.7e-26 93.0 1.6 2e-26 92.8 0.2 1.8 2 0 0 2 2 2 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.17 001082763.1_37925001_2 - 1.3e-11 44.4 0.0 2.6e-11 43.4 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.22 001082763.1_37925001_2 - 0.00065 19.8 0.0 0.002 18.2 0.0 1.9 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain p450 PF00067.20 001082103.1_37925001_1 - 1.7e-127 425.8 0.0 2.1e-127 425.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 S_100 PF01023.17 001082187.1_37923001_1 - 2.7e-18 65.3 0.1 4.8e-18 64.5 0.1 1.4 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.30 001082187.1_37923001_1 - 1.4e-06 27.2 1.2 5.3e-06 25.5 0.3 2.1 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.4 001082187.1_37923001_1 - 7.2e-06 26.3 0.1 1.1e-05 25.6 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.4 001082187.1_37923001_1 - 0.00089 18.5 0.7 0.00089 18.5 0.7 2.0 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.4 001082187.1_37923001_1 - 0.00092 18.8 0.9 0.064 13.1 0.3 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.4 001082187.1_37923001_1 - 0.012 15.3 1.2 0.046 13.4 1.2 1.9 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_11 PF08976.9 001082187.1_37923001_1 - 0.031 15.0 0.0 0.052 14.3 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain Sarcolipin PF05366.9 001082387.1_37922001_2 - 2e-22 78.4 5.7 3e-22 77.9 5.7 1.3 1 0 0 1 1 1 1 Sarcolipin EF-hand_1 PF00036.30 001082154.1_37922001_1 - 5.1e-22 75.6 23.3 4.1e-05 22.7 0.5 7.5 7 0 0 7 7 7 6 EF hand EF-hand_7 PF13499.4 001082154.1_37922001_1 - 7.1e-18 64.7 24.1 5.8e-07 29.7 0.6 4.4 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.4 001082154.1_37922001_1 - 2.3e-16 58.1 18.7 0.0049 16.6 0.0 7.3 7 0 0 7 7 7 6 EF-hand domain EF-hand_5 PF13202.4 001082154.1_37922001_1 - 7.4e-16 56.7 33.8 0.0001 21.5 0.8 7.4 8 0 0 8 8 8 6 EF hand EF-hand_8 PF13833.4 001082154.1_37922001_1 - 9.4e-11 41.2 13.4 0.00078 19.0 0.0 5.2 5 1 0 5 5 5 4 EF-hand domain pair SPARC_Ca_bdg PF10591.7 001082154.1_37922001_1 - 0.003 17.7 16.8 2.7 8.2 0.8 4.4 3 1 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region Nucleos_tra2_C PF07662.11 001082791.1_37925001_2 - 2.7e-72 242.9 3.7 2.7e-72 242.9 3.7 2.7 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.18 001082791.1_37925001_2 - 1.2e-23 83.3 5.4 1.2e-23 83.3 5.4 3.2 4 0 0 4 4 4 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.12 001082791.1_37925001_2 - 4.4e-07 30.0 7.1 4.4e-07 30.0 7.1 3.3 3 2 0 3 3 3 1 Nucleoside recognition Glyco_hydro_15 PF00723.19 001082301.1_37929001_2 - 3.2e-113 378.8 0.0 4.1e-113 378.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Ldh_1_N PF00056.21 001098561.1_39723001_1 - 7.3e-50 168.6 0.9 1.1e-49 168.1 0.9 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 001098561.1_39723001_1 - 1.5e-23 83.4 0.0 2.8e-23 82.5 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.14 001098561.1_39723001_1 - 0.0013 18.2 0.0 0.0042 16.5 0.0 1.8 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase PAS_3 PF08447.10 001082205.1_37927001_2 - 5.6e-19 68.1 0.1 1.3e-12 47.7 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS PF00989.23 001082205.1_37927001_2 - 9.5e-15 54.4 0.0 6.6e-13 48.5 0.0 2.5 2 0 0 2 2 2 1 PAS fold PAS_11 PF14598.4 001082205.1_37927001_2 - 4.9e-13 49.1 0.0 3.5e-10 39.9 0.0 2.4 2 0 0 2 2 2 2 PAS domain HLH PF00010.24 001082205.1_37927001_2 - 1.4e-05 24.8 0.2 3e-05 23.7 0.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_4 PF08448.8 001082205.1_37927001_2 - 0.021 15.0 0.1 0.93 9.6 0.0 2.4 2 0 0 2 2 2 0 PAS fold PAS_9 PF13426.5 001082205.1_37927001_2 - 0.041 14.0 0.0 0.49 10.6 0.0 2.6 3 0 0 3 3 3 0 PAS domain IL8 PF00048.18 001082293.1_37923001_3 - 4.3e-16 58.7 0.7 4.3e-16 58.7 0.7 1.8 2 0 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like Pkinase PF00069.23 001101705.1_37924001_3 - 2.5e-75 253.1 0.0 3.1e-75 252.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001101705.1_37924001_3 - 5.2e-29 101.2 0.0 7.4e-29 100.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001101705.1_37924001_3 - 4e-08 32.8 0.0 8.5e-08 31.7 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.12 001101705.1_37924001_3 - 9.7e-06 24.9 0.0 1.5e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001101705.1_37924001_3 - 0.00053 19.9 0.1 0.34 10.7 0.3 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.20 001101705.1_37924001_3 - 0.0012 18.3 0.0 0.002 17.6 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Haemolytic PF01809.16 001101705.1_37924001_3 - 0.012 15.3 0.0 0.028 14.2 0.0 1.5 1 0 0 1 1 1 0 Haemolytic domain FTA2 PF13095.4 001101705.1_37924001_3 - 0.014 14.9 0.1 0.12 11.9 0.0 2.0 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.18 001101705.1_37924001_3 - 0.05 13.1 0.1 0.082 12.4 0.1 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase MIP PF00230.18 001099961.1_37923001_1 - 2e-79 266.4 14.6 2.5e-79 266.1 14.6 1.1 1 0 0 1 1 1 1 Major intrinsic protein DEAD PF00270.27 001098575.1_39724001_3 - 3.7e-44 150.5 0.3 5.8e-44 149.8 0.3 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001098575.1_39724001_3 - 4.3e-31 107.4 0.7 2e-30 105.3 0.1 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.13 001098575.1_39724001_3 - 8e-07 29.1 0.0 1.3e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.4 001098575.1_39724001_3 - 0.00083 19.6 0.4 0.0023 18.2 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.4 001098575.1_39724001_3 - 0.0043 16.7 0.0 0.007 16.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.12 001098575.1_39724001_3 - 0.078 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Helicase Flavi_DEAD PF07652.12 001098575.1_39724001_3 - 0.089 12.6 0.0 0.53 10.1 0.0 2.1 2 0 0 2 2 2 0 Flavivirus DEAD domain AAA_34 PF13872.4 001107138.1_45729001_1 - 1e-141 471.1 0.0 1.5e-141 470.5 0.0 1.3 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 Helicase_C_4 PF13871.4 001107138.1_45729001_1 - 3.2e-123 410.4 0.1 4.5e-123 409.9 0.1 1.2 1 0 0 1 1 1 1 C-terminal domain on Strawberry notch homologue ResIII PF04851.13 001107138.1_45729001_1 - 2.5e-07 30.7 0.0 7.2e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.29 001107138.1_45729001_1 - 0.1 12.9 0.1 0.3 11.4 0.1 1.8 1 0 0 1 1 1 0 Helicase conserved C-terminal domain PLA2_B PF01735.16 001082072.1_37925001_1 - 4.9e-144 480.3 0.0 6e-144 480.0 0.0 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain C2 PF00168.28 001082072.1_37925001_1 - 7e-16 58.3 0.0 1.7e-15 57.0 0.0 1.6 1 0 0 1 1 1 1 C2 domain Caveolin PF01146.15 001195310.1_39527001_1 - 2.1e-55 186.2 1.4 3.7e-55 185.4 1.4 1.4 1 0 0 1 1 1 1 Caveolin V-set_2 PF15910.3 001082207.1_37922001_3 - 1.1e-13 51.2 2.2 5.1e-13 49.0 2.0 1.9 1 1 1 2 2 2 1 ICOS V-set domain V-set PF07686.15 001082207.1_37922001_3 - 2e-06 27.8 0.2 3.1e-06 27.2 0.2 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain CMV_1a_C PF12503.6 001082207.1_37922001_3 - 0.043 13.7 0.1 0.07 13.0 0.1 1.4 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein C terminal CD34_antigen PF06365.10 001082207.1_37922001_3 - 0.19 11.2 0.0 0.27 10.7 0.0 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family Enolase_C PF00113.20 001082085.1_37923001_2 - 2.5e-153 509.4 0.0 3.2e-153 509.1 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.14 001082085.1_37923001_2 - 8.8e-60 200.5 0.0 1.5e-59 199.7 0.0 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.4 001082085.1_37923001_2 - 4.8e-07 29.5 0.0 9.4e-07 28.6 0.0 1.5 1 1 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.9 001082085.1_37923001_2 - 2.7e-05 23.3 0.4 5.3e-05 22.3 0.4 1.5 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus WAP PF00095.19 001169023.1_40423001_3 - 2.2e-15 56.6 39.8 2.5e-08 34.1 19.1 2.5 2 0 0 2 2 2 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' C2-set_2 PF08205.10 001082663.1_37922001_1 - 1.4e-20 73.0 0.0 3.5e-20 71.7 0.0 1.7 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain V-set PF07686.15 001082663.1_37922001_1 - 1.5e-09 37.8 0.1 4.1e-09 36.4 0.1 1.7 1 1 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.14 001082663.1_37922001_1 - 4.2e-09 36.2 0.0 2.9e-05 23.9 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.4 001082663.1_37922001_1 - 5.9e-09 36.3 0.1 0.00093 19.6 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001082663.1_37922001_1 - 4e-07 30.2 0.0 0.0039 17.4 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001082663.1_37922001_1 - 7.3e-07 29.1 0.0 0.00043 20.3 0.0 3.2 3 1 0 3 3 3 1 Immunoglobulin domain DUF2892 PF11127.6 001082663.1_37922001_1 - 0.11 12.4 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2892) BAR_3 PF16746.3 001082174.1_37925001_1 - 5.3e-93 310.9 13.8 1e-92 310.0 13.8 1.5 1 0 0 1 1 1 1 BAR domain of APPL family ArfGap PF01412.16 001082174.1_37925001_1 - 4.8e-40 136.1 0.1 4.8e-40 136.1 0.1 2.3 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf PH PF00169.27 001082174.1_37925001_1 - 5.1e-15 55.7 0.6 1.3e-14 54.4 0.6 1.8 1 0 0 1 1 1 1 PH domain Ank_2 PF12796.5 001082174.1_37925001_1 - 1.1e-14 54.6 1.3 1.5e-08 34.9 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001082174.1_37925001_1 - 1.5e-10 41.0 0.8 2.9e-07 30.5 0.2 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.28 001082174.1_37925001_1 - 1.6e-06 28.2 0.6 0.09 13.1 0.0 4.4 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.4 001082174.1_37925001_1 - 9e-06 26.0 0.1 0.0031 17.9 0.0 3.4 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 001082174.1_37925001_1 - 2.4e-05 24.2 0.1 0.15 12.6 0.0 4.3 4 0 0 4 4 4 1 Ankyrin repeat PH_8 PF15409.4 001082174.1_37925001_1 - 0.065 13.4 0.2 0.22 11.7 0.2 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain PH_11 PF15413.4 001082174.1_37925001_1 - 0.16 12.3 8.5 0.42 10.9 3.3 3.2 2 1 0 2 2 2 0 Pleckstrin homology domain Reprolysin PF01421.17 001082677.1_37926001_3 - 4.4e-73 245.3 0.5 4.4e-73 245.3 0.5 2.0 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.17 001082677.1_37926001_3 - 6.5e-23 81.4 0.1 1.1e-22 80.7 0.1 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_CR PF08516.10 001082677.1_37926001_3 - 1.4e-22 80.1 5.2 1.4e-22 80.1 5.2 3.7 3 2 0 3 3 3 1 ADAM cysteine-rich Disintegrin PF00200.21 001082677.1_37926001_3 - 2.5e-17 63.3 26.6 2.5e-17 63.3 26.6 4.1 4 1 0 4 4 4 1 Disintegrin Reprolysin_5 PF13688.4 001082677.1_37926001_3 - 0.00018 21.6 0.0 0.00047 20.2 0.0 1.8 1 1 0 1 1 1 1 Metallo-peptidase family M12 Annexin PF00191.18 001098567.1_39723001_1 - 5.8e-93 304.9 12.1 2.6e-25 88.1 0.3 4.2 4 0 0 4 4 4 4 Annexin Myb_DNA-bind_7 PF15963.3 001098567.1_39723001_1 - 0.00025 20.7 0.3 0.91 9.3 0.0 3.6 2 1 1 3 3 3 2 Myb DNA-binding like adh_short PF00106.23 001082752.1_37924001_3 - 8.6e-45 152.5 0.0 1.1e-44 152.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001082752.1_37924001_3 - 7e-25 87.8 0.0 1e-24 87.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.8 001082752.1_37924001_3 - 0.00025 20.4 0.0 0.00037 19.8 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) UPF0029 PF01205.17 001082640.1_37929001_3 - 3.4e-33 114.0 0.0 5.1e-33 113.4 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.20 001082640.1_37929001_3 - 2.4e-17 63.2 0.3 4.8e-17 62.2 0.3 1.5 1 0 0 1 1 1 1 RWD domain PFK PF00365.18 001082748.1_37926001_2 - 2.4e-202 670.0 9.3 8.8e-110 366.3 3.6 2.1 2 0 0 2 2 2 2 Phosphofructokinase DUF1899 PF08953.9 001082687.1_37924001_2 - 2.4e-33 113.7 0.0 4.4e-33 112.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.3 001082687.1_37924001_2 - 6.8e-20 70.5 0.0 1.2e-19 69.7 0.0 1.5 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.30 001082687.1_37924001_2 - 7.2e-13 48.7 7.7 0.00044 20.9 0.2 4.5 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001082687.1_37924001_2 - 4.8e-06 26.6 0.1 0.0032 17.6 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Trimer_CC PF08954.9 001082687.1_37924001_2 - 1.7e-05 24.1 0.1 0.0028 17.1 0.1 2.6 2 0 0 2 2 2 2 Trimerisation motif Pkinase PF00069.23 001082367.1_37929001_3 - 2.3e-63 213.9 0.0 2.3e-63 213.9 0.0 3.2 4 1 1 5 5 5 1 Protein kinase domain Pkinase_Tyr PF07714.15 001082367.1_37929001_3 - 1.2e-30 106.5 0.0 4.8e-30 104.6 0.0 2.1 1 0 0 1 1 1 1 Protein tyrosine kinase Rho_Binding PF08912.9 001082367.1_37929001_3 - 4.7e-23 81.6 15.5 4.7e-23 81.6 15.5 13.3 4 3 10 14 14 14 1 Rho Binding PH PF00169.27 001082367.1_37929001_3 - 1e-05 25.8 4.6 8.3e-05 22.9 0.1 3.3 3 0 0 3 3 3 1 PH domain C1_1 PF00130.20 001082367.1_37929001_3 - 0.00021 21.0 5.3 0.00044 20.0 5.3 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) HR1 PF02185.14 001082367.1_37929001_3 - 0.0036 17.3 15.4 0.0036 17.3 15.4 10.8 7 4 3 11 11 11 2 Hr1 repeat APH PF01636.21 001082367.1_37929001_3 - 0.028 14.2 5.8 0.029 14.2 0.1 3.2 2 2 1 3 3 3 0 Phosphotransferase enzyme family Pkinase_C PF00433.22 001082367.1_37929001_3 - 0.046 14.3 4.8 0.19 12.3 4.8 2.2 1 1 0 1 1 1 0 Protein kinase C terminal domain 7tm_1 PF00001.19 001082383.1_37923001_3 - 6.2e-65 219.0 10.1 7.7e-65 218.6 10.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CholecysA-Rec_N PF09193.8 001082383.1_37923001_3 - 2.9e-21 75.1 0.0 7.3e-21 73.8 0.0 1.8 1 0 0 1 1 1 1 Cholecystokinin A receptor, N-terminal 7TM_GPCR_Srsx PF10320.7 001082383.1_37923001_3 - 7.7e-10 38.4 19.6 3e-09 36.5 19.6 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001082383.1_37923001_3 - 1.9e-08 34.3 8.4 1.9e-08 34.3 8.4 1.5 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001082383.1_37923001_3 - 7.6e-05 22.0 14.8 7.6e-05 22.0 14.8 2.1 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx WAP PF00095.19 001169024.1_40422001_3 - 2.6e-08 34.0 12.6 2.6e-08 34.0 12.6 2.1 2 0 0 2 2 2 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Aminotran_1_2 PF00155.19 001013164.3_45723001_1 - 8.7e-54 182.9 0.0 1e-53 182.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.18 001013164.3_45723001_1 - 8.9e-06 24.3 0.0 2.8e-05 22.7 0.0 1.7 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.15 001013164.3_45723001_1 - 0.0011 18.2 0.0 0.0032 16.7 0.0 1.7 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Herpes_gI PF01688.15 001013164.3_45723001_1 - 0.016 15.0 0.0 0.029 14.1 0.0 1.3 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein I Aminotran_5 PF00266.17 001013164.3_45723001_1 - 0.042 12.7 0.0 0.076 11.8 0.0 1.4 1 1 0 1 1 1 0 Aminotransferase class-V Porin_3 PF01459.20 001082718.1_37922001_1 - 6e-84 281.6 1.3 6.7e-84 281.4 1.3 1.0 1 0 0 1 1 1 1 Eukaryotic porin 7tm_1 PF00001.19 001082773.1_37923001_1 - 2e-50 171.4 21.8 2.8e-50 170.9 21.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srd PF10317.7 001082773.1_37923001_1 - 8.7e-06 25.0 22.3 0.0053 15.9 8.8 2.4 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srd Vma12 PF11712.6 001082773.1_37923001_1 - 4.6 7.2 5.1 2 8.3 0.3 2.2 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase MHC_I PF00129.16 001071790.1_39722001_3 - 4.6e-57 192.3 0.6 5.5e-57 192.1 0.6 1.0 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 MHC_I_3 PF16497.3 001071790.1_39722001_3 - 4.4e-11 42.5 0.3 6.8e-11 41.9 0.3 1.2 1 0 0 1 1 1 1 MHC-I family domain Gla PF00594.18 001082394.1_37926001_2 - 3.1e-19 68.8 9.2 4.7e-19 68.2 9.2 1.3 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain Ion_trans PF00520.29 001082394.1_37926001_3 - 2.9e-27 95.3 11.4 4.7e-27 94.6 11.4 1.3 1 0 0 1 1 1 1 Ion transport protein CLZ PF16526.3 001082394.1_37926001_3 - 3.4e-25 88.0 6.1 7.1e-25 87.0 6.1 1.6 1 0 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels cNMP_binding PF00027.27 001082394.1_37926001_3 - 6.2e-18 64.5 0.0 1.1e-17 63.7 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.14 001082394.1_37926001_3 - 0.022 14.6 4.4 0.055 13.3 4.4 1.8 1 0 0 1 1 1 0 Ion channel Mod_r PF07200.11 001082394.1_37926001_3 - 5.2 7.0 8.2 0.29 11.1 1.6 2.2 3 0 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein CybS PF05328.10 001097516.1_49822001_1 - 3.9e-23 81.5 0.2 5.4e-23 81.0 0.2 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit RUN PF02759.17 001047116.1_45728001_1 - 3.7e-25 88.3 0.0 6.3e-25 87.6 0.0 1.4 1 0 0 1 1 1 1 RUN domain 7tm_1 PF00001.19 001082314.1_37923001_3 - 1.7e-36 125.7 15.6 5.2e-36 124.1 15.6 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Trep_Strep PF09605.8 001082314.1_37923001_3 - 0.0095 15.8 3.4 0.0095 15.8 3.4 3.6 3 2 1 4 4 4 1 Hypothetical bacterial integral membrane protein (Trep_Strep) 7TM_GPCR_Srx PF10328.7 001082314.1_37923001_3 - 0.042 13.0 9.3 0.086 12.0 9.3 1.5 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx Adipogenin PF15202.4 001082314.1_37923001_3 - 0.68 9.9 0.0 0.68 9.9 0.0 2.9 4 0 0 4 4 4 0 Adipogenin 7tm_1 PF00001.19 001078656.1_39522001_1 - 7.6e-34 117.0 30.5 8.3e-32 110.3 30.5 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001078656.1_39522001_1 - 3.1e-12 46.7 20.5 1.2e-10 41.5 15.4 2.7 1 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001078656.1_39522001_1 - 8.1e-06 25.3 27.7 1.9e-05 24.0 27.7 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Insulin PF00049.16 001082320.1_37922001_1 - 5.5e-07 30.4 2.2 2.6e-06 28.2 2.2 2.0 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family V-set PF07686.15 001082208.1_37923001_1 - 7.2e-09 35.6 0.7 2.3e-08 34.0 0.0 2.1 3 0 0 3 3 3 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001082208.1_37923001_1 - 3.8e-07 30.5 0.2 0.019 15.4 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001082208.1_37923001_1 - 0.00073 19.7 0.7 0.33 11.2 0.1 2.6 2 1 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001082208.1_37923001_1 - 0.0035 17.2 0.0 0.0093 15.9 0.0 1.8 1 1 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001082208.1_37923001_1 - 0.0036 17.3 0.5 0.25 11.4 0.1 2.6 2 1 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 001082208.1_37923001_1 - 0.013 15.4 0.0 0.11 12.5 0.0 2.4 2 1 0 2 2 2 0 Immunoglobulin I-set domain Resistin PF06954.9 020509.3_32922001_1 - 5.8e-31 106.8 13.4 5.8e-31 106.8 13.4 1.7 2 0 0 2 2 2 1 Resistin Peptidase_C2 PF00648.19 001100188.1_49827001_1 - 1.2e-127 424.8 0.0 2e-127 424.2 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 001100188.1_49827001_1 - 7.5e-55 185.0 0.0 1.7e-54 183.8 0.0 1.6 2 0 0 2 2 2 1 Calpain large subunit, domain III EF-hand_1 PF00036.30 001100188.1_49827001_1 - 1.9e-05 23.8 2.5 0.019 14.4 0.0 4.2 5 0 0 5 5 5 2 EF hand EF-hand_8 PF13833.4 001100188.1_49827001_1 - 2e-05 24.1 1.1 0.0001 21.9 0.2 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.4 001100188.1_49827001_1 - 7.6e-05 22.2 0.8 0.059 13.2 0.0 4.3 4 0 0 4 4 4 1 EF-hand domain EF-hand_7 PF13499.4 001100188.1_49827001_1 - 0.076 13.4 5.8 6.6 7.1 0.0 3.8 3 2 0 3 3 3 0 EF-hand domain pair Caveolin PF01146.15 001168712.1_40427001_1 - 3e-55 185.7 0.8 5.4e-55 184.9 0.8 1.3 1 0 0 1 1 1 1 Caveolin FGF PF00167.16 001110241.1_39722001_1 - 2.8e-42 143.6 0.0 3.9e-42 143.2 0.0 1.2 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.11 001110241.1_39722001_1 - 8.8e-05 22.6 0.1 0.037 14.1 0.0 1.5 1 1 1 2 2 2 2 Fascin domain IL1 PF00340.17 001110241.1_39722001_1 - 0.0022 17.6 0.0 0.0031 17.0 0.0 1.2 1 0 0 1 1 1 1 Interleukin-1 / 18 Peptidase_C14 PF00656.20 001082117.1_37922001_1 - 2e-53 181.8 0.1 2.4e-53 181.5 0.1 1.1 1 0 0 1 1 1 1 Caspase domain ThiF PF00899.19 001082371.2_37927001_2 - 7.1e-122 405.3 0.0 4.5e-73 245.5 0.0 2.1 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.7 001082371.2_37927001_2 - 7.6e-97 324.0 0.0 1.6e-96 323.0 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.8 001082371.2_37927001_2 - 6.1e-37 126.1 0.0 1.5e-36 124.9 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin fold domain E1_FCCH PF16190.3 001082371.2_37927001_2 - 5.7e-34 116.0 0.1 9.9e-34 115.3 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.3 001082371.2_37927001_2 - 7.9e-28 96.3 0.5 2.5e-27 94.7 0.5 2.0 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle DUF1186 PF06685.9 001082371.2_37927001_2 - 0.12 11.6 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1186) Sugar_tr PF00083.22 001082127.1_37924001_1 - 4.5e-31 108.1 13.3 6e-31 107.7 13.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001082127.1_37924001_1 - 3e-24 85.5 20.5 4.7e-24 84.8 20.5 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily 7tm_1 PF00001.19 001173118.1_09925001_1 - 2.7e-38 131.6 22.7 2e-23 82.9 12.1 2.5 2 0 0 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001173118.1_09925001_1 - 8.3e-06 25.2 19.7 0.00062 19.1 2.3 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001173118.1_09925001_1 - 0.0041 16.3 10.6 0.0041 16.3 10.6 2.4 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Pkinase PF00069.23 001159785.1_43528001_3 - 4.8e-71 239.1 0.1 7.5e-71 238.4 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001159785.1_43528001_3 - 3.1e-45 154.4 0.3 8.9e-45 152.9 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase POLO_box PF00659.16 001159785.1_43528001_3 - 3.5e-09 36.6 0.1 3.8e-08 33.3 0.0 2.6 2 0 0 2 2 2 1 POLO box duplicated region Kinase-like PF14531.4 001159785.1_43528001_3 - 0.0019 17.4 0.0 0.0054 16.0 0.0 1.7 1 1 0 1 1 1 1 Kinase-like DUF4520 PF15016.4 001159785.1_43528001_3 - 0.0074 16.2 0.4 0.2 11.6 0.0 3.1 4 0 0 4 4 4 1 Domain of unknown function (DUF4520) Ig_3 PF13927.4 001135510.1_43524001_1 - 0.00048 20.6 0.1 0.0016 18.8 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001135510.1_43524001_1 - 0.016 15.2 0.0 0.035 14.2 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain Ig_2 PF13895.4 001135510.1_43524001_1 - 0.054 13.7 0.0 0.35 11.1 0.0 2.1 2 0 0 2 2 2 0 Immunoglobulin domain V-set PF07686.15 001135510.1_43524001_1 - 0.08 13.0 1.3 22 5.1 0.0 3.1 1 1 2 3 3 3 0 Immunoglobulin V-set domain EpoR_lig-bind PF09067.8 001135510.1_43524001_1 - 0.085 12.9 0.0 0.21 11.7 0.0 1.5 2 0 0 2 2 2 0 Erythropoietin receptor, ligand binding Band_7 PF01145.23 001164360.1_32927001_2 - 5.2e-20 72.1 0.1 8.5e-20 71.4 0.1 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family Catalase-rel PF06628.10 001164360.1_32927001_2 - 0.07 13.2 0.1 0.16 12.1 0.1 1.6 1 0 0 1 1 1 0 Catalase-related immune-responsive DUF4346 PF14251.4 001164360.1_32927001_2 - 0.13 12.2 2.4 0.3 11.0 2.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4346) HLH PF00010.24 001123130.1_49821001_1 - 2.4e-12 46.5 0.0 3.7e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Lipase_3 PF01764.23 001123130.1_49821001_1 - 0.21 11.3 1.4 0.33 10.7 1.4 1.2 1 0 0 1 1 1 0 Lipase (class 3) Ribosomal_60s PF00428.17 001123130.1_49821001_1 - 1.5 9.3 9.5 2.9 8.4 9.5 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein Acyl_transf_1 PF00698.19 001123130.1_49821001_1 - 2.1 7.6 3.8 2.9 7.1 3.8 1.1 1 0 0 1 1 1 0 Acyl transferase domain PBP PF01161.18 001133770.1_43523001_2 - 3.7e-09 36.8 0.0 6.3e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein adh_short PF00106.23 001172857.1_09923001_3 - 3.1e-48 163.7 2.0 4e-48 163.4 2.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001172857.1_09923001_3 - 2.3e-24 86.1 0.8 3e-24 85.7 0.8 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001172857.1_09923001_3 - 5.7e-09 36.0 0.6 8.1e-09 35.5 0.6 1.1 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.17 001172857.1_09923001_3 - 0.0017 17.6 0.1 0.0027 16.9 0.1 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 2-Hacid_dh_C PF02826.17 001172857.1_09923001_3 - 0.0099 15.1 0.1 0.016 14.4 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.18 001172857.1_09923001_3 - 0.011 15.7 0.1 0.017 15.0 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF1776 PF08643.8 001172857.1_09923001_3 - 0.042 13.1 0.2 0.18 11.0 0.2 1.8 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) 3HCDH_N PF02737.16 001172857.1_09923001_3 - 0.049 13.4 0.5 0.069 12.9 0.5 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.12 001172857.1_09923001_3 - 0.051 12.7 0.1 0.076 12.1 0.1 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 001172857.1_09923001_3 - 0.078 12.1 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AdoHcyase_NAD PF00670.19 001172857.1_09923001_3 - 0.14 12.0 0.5 0.7 9.8 0.1 2.0 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_10 PF13460.4 001172857.1_09923001_3 - 0.15 11.9 0.1 0.26 11.1 0.1 1.4 1 0 0 1 1 1 0 NAD(P)H-binding p450 PF00067.20 001129904.1_39524001_3 - 2.1e-132 442.0 0.3 2.5e-132 441.8 0.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3687 PF12459.6 001129904.1_39524001_3 - 0.11 11.9 1.0 0.24 10.8 1.0 1.6 1 0 0 1 1 1 0 D-Ala-teichoic acid biosynthesis protein Serpin PF00079.18 001132481.1_43523001_3 - 1.6e-110 369.8 0.1 1.9e-110 369.5 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) 7tm_1 PF00001.19 001173418.1_09923001_1 - 1.1e-77 260.8 10.9 1.4e-77 260.4 10.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001173418.1_09923001_1 - 1e-10 41.3 7.5 2.3e-10 40.2 7.5 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001173418.1_09923001_1 - 5.8e-07 29.4 13.0 0.00027 20.6 9.8 2.9 2 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001173418.1_09923001_1 - 0.006 15.8 7.9 0.006 15.8 7.9 2.3 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF3413 PF11893.6 001173418.1_09923001_1 - 9.6 5.1 12.9 1.9 7.4 8.4 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF3413) SR-25 PF10500.7 001144837.2_39724001_1 - 0.015 14.8 14.4 0.023 14.2 14.4 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Filament PF00038.19 001144837.2_39724001_3 - 4.2e-118 394.3 30.7 6e-118 393.8 30.7 1.2 1 0 0 1 1 1 1 Intermediate filament protein DUF1664 PF07889.10 001144837.2_39724001_3 - 0.59 10.0 14.1 1.9 8.4 1.1 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.8 001144837.2_39724001_3 - 2.3 8.3 20.6 0.34 11.0 1.7 4.5 1 1 2 4 4 4 0 Fibrinogen alpha/beta chain family Bacillus_HBL PF05791.9 001144837.2_39724001_3 - 6.1 6.4 12.1 0.5 10.0 2.7 3.3 2 1 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) bZIP_1 PF00170.19 001166182.1_39525001_1 - 1.2e-08 34.8 14.0 2.4e-08 33.8 14.0 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 001166182.1_39525001_1 - 6e-06 26.1 14.1 1.3e-05 25.0 14.1 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 001166182.1_39525001_1 - 4.2e-05 23.9 8.0 7.1e-05 23.1 8.0 1.2 1 0 0 1 1 1 1 bZIP Maf transcription factor Macoilin PF09726.7 001166182.1_39525001_1 - 0.027 12.9 7.5 0.039 12.4 7.5 1.1 1 0 0 1 1 1 0 Transmembrane protein HALZ PF02183.16 001166182.1_39525001_1 - 0.39 10.8 3.7 0.77 9.9 3.3 1.6 1 1 0 1 1 1 0 Homeobox associated leucine zipper EF-1_beta_acid PF10587.7 001166182.1_39525001_1 - 0.91 9.9 4.9 2.3 8.6 4.9 1.7 1 0 0 1 1 1 0 Eukaryotic elongation factor 1 beta central acidic region APG6 PF04111.10 001166182.1_39525001_1 - 2.5 7.3 5.7 3.7 6.7 5.7 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 wnt PF00110.17 001168699.1_22425001_2 - 1.1e-121 405.9 25.1 1.4e-121 405.6 25.1 1.1 1 0 0 1 1 1 1 wnt family p450 PF00067.20 001172939.1_09925001_3 - 3.9e-103 345.5 2.2 5e-103 345.2 2.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 Paf67 PF10255.7 001135207.2_39724001_1 - 3.2e-175 582.8 10.2 4.8e-175 582.2 10.2 1.3 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.15 001135207.2_39724001_1 - 0.011 15.7 0.3 0.19 11.8 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.5 001135207.2_39724001_1 - 0.028 14.5 0.1 0.073 13.1 0.1 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.26 001135207.2_39724001_1 - 0.029 14.1 0.2 0.92 9.3 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC5 PF12862.5 001135207.2_39724001_1 - 0.23 11.4 1.7 3.5 7.6 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 5 7tm_1 PF00001.19 001172982.1_09924001_3 - 2.9e-28 98.7 30.3 1.4e-26 93.2 30.3 2.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001172982.1_09924001_3 - 1.8e-11 43.8 20.1 7.5e-10 38.5 20.1 2.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001172982.1_09924001_3 - 1e-05 25.3 13.7 1e-05 25.3 13.7 2.3 1 1 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001172982.1_09924001_3 - 0.00012 21.4 16.1 0.00012 21.4 16.1 2.3 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx GPR_Gpa2_C PF11970.6 001172982.1_09924001_3 - 3.2 7.7 5.2 1.3 9.0 0.8 2.4 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 C-term Guanylin PF02058.13 001172958.1_09922001_2 - 3e-32 110.8 3.0 3e-32 110.8 3.0 1.7 2 0 0 2 2 2 1 Guanylin precursor Enterotoxin_ST PF02048.14 001172958.1_09922001_2 - 0.012 16.0 3.4 0.023 15.0 3.4 1.5 1 0 0 1 1 1 0 Heat-stable enterotoxin ST Pkinase_Tyr PF07714.15 001168696.1_22429001_2 - 1.6e-92 309.4 0.0 2.4e-92 308.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Sema PF01403.17 001168696.1_22429001_2 - 7.4e-60 202.7 3.2 1.3e-59 202.0 3.2 1.3 1 0 0 1 1 1 1 Sema domain Pkinase PF00069.23 001168696.1_22429001_2 - 1e-39 136.4 0.0 1.7e-39 135.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain TIG PF01833.22 001168696.1_22429001_2 - 4.6e-39 132.2 13.5 2.4e-13 49.8 0.7 4.7 4 0 0 4 4 4 4 IPT/TIG domain PSI PF01437.23 001168696.1_22429001_2 - 4e-05 23.9 15.0 4e-05 23.9 15.0 2.9 2 0 0 2 2 2 1 Plexin repeat Kinase-like PF14531.4 001168696.1_22429001_2 - 0.00033 19.9 0.0 0.00055 19.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Linker_histone PF00538.17 001168696.1_22429001_2 - 0.099 12.9 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 linker histone H1 and H5 family adh_short PF00106.23 001172961.1_09922001_1 - 4.8e-58 195.7 0.3 6.4e-58 195.3 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001172961.1_09922001_1 - 1e-44 152.7 0.0 1.3e-44 152.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001172961.1_09922001_1 - 2.2e-09 37.4 0.1 3.5e-09 36.7 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.19 001172961.1_09922001_1 - 0.00045 19.6 0.0 0.00057 19.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 001172961.1_09922001_1 - 0.00093 18.5 0.0 0.0015 17.9 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Lectin_leg-like PF03388.11 001172961.1_09922001_1 - 0.0029 16.9 0.0 0.0042 16.3 0.0 1.3 1 0 0 1 1 1 1 Legume-like lectin family zf-H2C2_2 PF13465.4 001172890.1_09928001_3 - 1.5e-55 183.1 78.1 5.2e-08 32.9 0.3 10.8 10 0 0 10 10 10 9 Zinc-finger double domain zf-C2H2 PF00096.24 001172890.1_09928001_3 - 6.8e-39 130.1 81.8 2.6e-05 24.3 1.6 9.8 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001172890.1_09928001_3 - 4e-15 55.1 83.6 0.0017 18.9 0.7 10.1 10 0 0 10 10 9 8 C2H2-type zinc finger FAM178 PF14816.4 001172890.1_09928001_3 - 0.0064 15.4 1.5 1.7 7.4 0.1 2.9 2 1 1 4 4 4 2 Family of unknown function, FAM178 XPA_N PF01286.16 001172890.1_09928001_3 - 0.015 15.2 39.3 1.6 8.7 0.7 8.8 8 0 0 8 8 8 0 XPA protein N-terminal zf-C2H2_6 PF13912.4 001172890.1_09928001_3 - 0.017 15.0 0.5 0.017 15.0 0.5 8.8 9 0 0 9 9 9 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001172890.1_09928001_3 - 0.027 14.5 49.8 0.34 10.9 3.8 6.8 2 1 6 8 8 8 0 Zinc ribbon domain zf-C2H2_11 PF16622.3 001172890.1_09928001_3 - 0.04 13.5 43.2 0.16 11.6 0.0 7.6 7 0 0 7 7 7 0 zinc-finger C2H2-type DZR PF12773.5 001172890.1_09928001_3 - 1.1 9.2 44.2 0.085 12.8 4.2 6.0 1 1 3 4 4 3 0 Double zinc ribbon zinc_ribbon_15 PF17032.3 001172890.1_09928001_3 - 1.3 9.7 42.6 4.7 7.9 4.2 5.2 1 1 4 5 5 5 0 zinc-ribbon family C1_4 PF07975.10 001172890.1_09928001_3 - 2.6 8.3 49.7 0.02 15.0 2.3 6.3 1 1 6 7 7 7 0 TFIIH C1-like domain OB_NTP_bind PF07717.14 001132058.1_43527001_3 - 5.8e-21 74.6 0.0 1.1e-20 73.7 0.0 1.4 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.21 001132058.1_43527001_3 - 1.1e-19 70.5 0.0 2.2e-19 69.6 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.29 001132058.1_43527001_3 - 2.5e-13 50.2 0.1 5.2e-13 49.2 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.27 001132058.1_43527001_3 - 0.00075 19.2 0.0 0.002 17.8 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ABC_tran PF00005.25 001132058.1_43527001_3 - 0.0011 19.4 0.2 0.033 14.6 0.0 2.3 1 1 0 2 2 2 1 ABC transporter AAA_22 PF13401.4 001132058.1_43527001_3 - 0.0015 18.6 0.0 0.0049 17.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.4 001132058.1_43527001_3 - 0.019 14.5 0.0 0.033 13.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.4 001132058.1_43527001_3 - 0.03 14.5 0.1 0.061 13.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain PBP_sp32 PF07222.10 001172907.1_09924001_2 - 4.9e-118 392.8 4.3 4.9e-118 392.8 4.3 1.8 2 0 0 2 2 2 1 Proacrosin binding protein sp32 Kazal_2 PF07648.13 001172907.1_09924001_2 - 0.00039 20.4 1.6 0.00039 20.4 1.6 3.5 3 0 0 3 3 3 1 Kazal-type serine protease inhibitor domain CobT PF06213.10 001172907.1_09924001_2 - 0.6 9.3 13.3 0.99 8.6 13.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Fur_reg_FbpB PF13040.4 001172907.1_09924001_2 - 1.6 8.2 5.8 3.2 7.2 5.8 1.5 1 0 0 1 1 1 0 Fur-regulated basic protein B DUF4746 PF15928.3 001172907.1_09924001_2 - 1.7 7.9 9.5 3.1 7.0 9.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DDHD PF02862.15 001172907.1_09924001_2 - 1.9 8.4 11.4 2.8 7.9 11.3 1.3 1 1 0 1 1 1 0 DDHD domain ALMT PF11744.6 001172907.1_09924001_2 - 2 7.0 3.9 2.9 6.5 3.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM176 PF14851.4 001172907.1_09924001_2 - 2.8 7.5 5.9 6.7 6.3 5.9 1.6 1 0 0 1 1 1 0 FAM176 family Plasmodium_Vir PF05795.9 001172907.1_09924001_2 - 3.1 7.0 6.7 6.1 6.0 6.7 1.4 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Presenilin PF01080.15 001172907.1_09924001_2 - 8.9 4.8 8.9 13 4.3 8.9 1.2 1 0 0 1 1 1 0 Presenilin Nucleo_P87 PF07267.9 001172907.1_09924001_2 - 9.1 4.9 6.5 14 4.3 6.5 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Serpin PF00079.18 001173013.1_09923001_1 - 7.4e-117 390.6 0.7 8.4e-117 390.5 0.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Maelstrom PF13017.4 001173013.1_09923001_1 - 0.11 12.0 0.1 0.25 10.8 0.1 1.6 1 0 0 1 1 1 0 piRNA pathway germ-plasm component YpzG PF14139.4 001173013.1_09923001_1 - 0.14 12.2 0.9 0.29 11.2 0.0 1.9 2 0 0 2 2 2 0 YpzG-like protein TPR_1 PF00515.26 001132671.1_43524001_2 - 3.2e-40 134.2 30.3 2.4e-06 27.0 0.0 9.0 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.15 001132671.1_43524001_2 - 1e-37 125.0 24.5 5.6e-06 25.9 1.6 9.6 9 0 0 9 9 9 7 Tetratricopeptide repeat DnaJ PF00226.29 001132671.1_43524001_2 - 6.5e-24 83.7 2.2 6.5e-24 83.7 2.2 2.7 3 0 0 3 3 2 1 DnaJ domain TPR_8 PF13181.4 001132671.1_43524001_2 - 4.2e-22 76.3 20.5 0.00034 20.5 0.4 8.8 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_19 PF14559.4 001132671.1_43524001_2 - 1.1e-16 60.9 13.2 0.007 16.7 0.2 6.5 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_16 PF13432.4 001132671.1_43524001_2 - 1.8e-16 60.4 4.7 0.00067 20.2 0.0 5.8 4 2 1 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.4 001132671.1_43524001_2 - 2.3e-16 59.1 26.9 7.9e-07 28.5 4.0 7.9 6 1 2 8 8 8 5 TPR repeat TPR_12 PF13424.4 001132671.1_43524001_2 - 5.5e-16 58.5 19.3 1.6e-05 25.0 1.0 6.5 4 1 2 6 6 6 5 Tetratricopeptide repeat TPR_17 PF13431.4 001132671.1_43524001_2 - 1.6e-15 56.1 16.9 9.6e-05 22.4 0.1 8.4 9 0 0 9 9 7 3 Tetratricopeptide repeat TPR_14 PF13428.4 001132671.1_43524001_2 - 1.5e-10 40.8 9.6 0.57 11.0 0.0 8.4 7 2 2 10 10 8 2 Tetratricopeptide repeat TPR_9 PF13371.4 001132671.1_43524001_2 - 1.6e-09 37.7 7.8 0.22 11.6 0.1 5.5 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.4 001132671.1_43524001_2 - 2.2e-08 33.4 11.8 0.089 12.7 0.5 7.4 7 0 0 7 7 7 2 Tetratricopeptide repeat ANAPC3 PF12895.5 001132671.1_43524001_2 - 6.5e-07 29.3 27.8 0.0049 16.9 0.3 6.0 1 1 6 7 7 7 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.4 001132671.1_43524001_2 - 8.6e-06 25.9 18.9 0.14 12.7 0.8 7.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.4 001132671.1_43524001_2 - 4.5e-05 23.1 17.6 0.58 10.0 0.4 6.5 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_4 PF07721.12 001132671.1_43524001_2 - 0.0047 17.3 0.1 4 8.2 0.0 3.4 2 0 0 2 2 2 1 Tetratricopeptide repeat RPT PF13446.4 001132671.1_43524001_2 - 0.056 13.3 0.0 0.28 11.0 0.0 2.2 1 0 0 1 1 1 0 A repeated domain in UCH-protein Sel1 PF08238.10 001132671.1_43524001_2 - 0.33 11.6 5.5 3.2 8.4 0.5 4.1 3 0 0 3 3 3 0 Sel1 repeat RPN7 PF10602.7 001132671.1_43524001_2 - 0.38 10.2 13.8 0.21 11.1 3.8 2.8 2 1 0 2 2 2 0 26S proteasome subunit RPN7 Alkyl_sulf_dimr PF14863.4 001132671.1_43524001_2 - 0.43 10.9 10.7 16 5.8 0.1 4.5 4 1 1 5 5 5 0 Alkyl sulfatase dimerisation MIT PF04212.16 001132671.1_43524001_2 - 1.1 9.2 27.2 0.45 10.5 1.2 6.2 4 2 1 5 5 5 0 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.7 001132671.1_43524001_2 - 3.4 7.1 6.2 12 5.3 0.1 4.5 4 1 1 5 5 5 0 SHNi-TPR Serpin PF00079.18 001008776.2_45723001_1 - 5.5e-99 331.8 0.0 4e-66 223.7 0.0 2.0 2 0 0 2 2 2 2 Serpin (serine protease inhibitor) RRM_1 PF00076.20 001132504.1_43528001_2 - 1.5e-49 165.6 0.0 6.7e-18 64.1 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.9 001132504.1_43528001_2 - 3.9e-08 33.1 0.0 0.12 12.2 0.0 3.5 3 0 0 3 3 3 3 RNA binding domain RRM_7 PF16367.3 001132504.1_43528001_2 - 4.8e-05 23.3 0.0 0.5 10.4 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif RRM_5 PF13893.4 001132504.1_43528001_2 - 5.4e-05 22.7 0.2 0.057 12.9 0.1 3.1 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.4 001132504.1_43528001_2 - 0.021 14.6 0.0 0.65 9.9 0.0 2.9 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif BNR_2 PF13088.4 015750.3_32924001_2 - 4.8e-40 137.5 0.0 6.4e-40 137.1 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.4 015750.3_32924001_2 - 9.5e-06 25.0 0.0 1.3e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.18 015750.3_32924001_2 - 2.7e-05 23.4 0.9 0.36 10.9 0.2 2.7 2 0 0 2 2 2 2 BNR/Asp-box repeat CHB_HEX_C PF03174.11 015750.3_32924001_2 - 0.1 12.4 0.0 0.34 10.8 0.0 1.8 1 0 0 1 1 1 0 Chitobiase/beta-hexosaminidase C-terminal domain p450 PF00067.20 001160288.1_37924001_2 - 1.5e-132 442.5 1.7 1.7e-132 442.3 1.7 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.20 001170929.1_37927001_1 - 3.6e-86 289.6 0.5 4.3e-86 289.3 0.5 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.23 001127269.1_39522001_1 - 3.9e-65 219.7 0.0 4.4e-65 219.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001127269.1_39522001_1 - 1.8e-30 106.0 0.0 2.6e-30 105.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 001127269.1_39522001_1 - 1.7e-08 34.5 0.3 2.3e-05 24.3 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.12 001127269.1_39522001_1 - 0.0001 21.6 0.0 0.00015 21.1 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 001127269.1_39522001_1 - 0.039 13.1 0.0 0.067 12.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like NDK PF00334.17 001133682.1_43522001_1 - 1.2e-55 187.1 0.0 1.4e-55 186.9 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase RAMP PF04901.11 001173011.1_09922001_2 - 1.7e-41 140.5 0.2 2.4e-41 140.1 0.2 1.2 1 0 0 1 1 1 1 Receptor activity modifying family Lectin_C PF00059.19 001173067.1_09922001_3 - 5.2e-09 36.7 1.7 7.7e-09 36.1 1.7 1.3 1 0 0 1 1 1 1 Lectin C-type domain DUF2360 PF10152.7 001173067.1_09922001_3 - 0.22 11.8 1.2 0.31 11.3 1.2 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) NOA36 PF06524.10 001173067.1_09922001_3 - 1.8 7.7 7.1 5.8 6.1 3.2 2.1 1 1 1 2 2 2 0 NOA36 protein Sushi PF00084.18 001173027.1_09924001_3 - 4.2e-69 228.9 35.3 1.8e-11 44.4 0.7 7.3 6 1 1 7 7 7 7 Sushi repeat (SCR repeat) ORC4_C PF14629.4 001132980.1_43529001_1 - 1.1e-50 171.8 4.3 1.7e-50 171.3 4.3 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.4 001132980.1_43529001_1 - 3.7e-12 46.8 0.1 7.1e-12 45.9 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.27 001132980.1_43529001_1 - 1.5e-09 38.2 0.1 2.6e-09 37.5 0.1 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.4 001132980.1_43529001_1 - 1.2e-07 32.0 0.1 2.6e-07 30.8 0.1 1.5 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.16 001132980.1_43529001_1 - 5.1e-06 26.4 0.6 8.5e-06 25.7 0.1 1.5 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea NACHT PF05729.10 001132980.1_43529001_1 - 0.00017 21.4 0.8 0.00042 20.2 0.8 1.7 1 1 0 1 1 1 1 NACHT domain AAA_19 PF13245.4 001132980.1_43529001_1 - 0.0006 20.0 0.1 0.0015 18.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.11 001132980.1_43529001_1 - 0.002 17.2 0.1 0.0032 16.5 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.4 001132980.1_43529001_1 - 0.0022 17.9 0.0 0.005 16.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain TniB PF05621.9 001132980.1_43529001_1 - 0.0043 16.2 0.4 0.012 14.7 0.4 1.6 1 1 0 1 1 1 1 Bacterial TniB protein NB-ARC PF00931.20 001132980.1_43529001_1 - 0.006 15.5 0.1 0.0097 14.8 0.1 1.2 1 0 0 1 1 1 1 NB-ARC domain DUF2075 PF09848.7 001132980.1_43529001_1 - 0.007 15.5 0.1 0.0099 15.0 0.1 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.18 001132980.1_43529001_1 - 0.011 14.7 0.0 0.017 14.1 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein DAP3 PF10236.7 001132980.1_43529001_1 - 0.04 12.9 1.3 0.23 10.4 0.1 2.3 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 Mg_chelatase PF01078.19 001132980.1_43529001_1 - 0.1 11.8 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Arm PF00514.21 001131749.1_43525001_3 - 0.0037 17.1 0.0 0.0071 16.2 0.0 1.5 1 0 0 1 1 1 1 Armadillo/beta-catenin-like repeat HMA PF00403.24 001131749.1_43525001_3 - 0.0063 16.8 0.1 0.011 16.1 0.1 1.3 1 0 0 1 1 1 1 Heavy-metal-associated domain vATP-synt_AC39 PF01992.14 001132906.2_43523001_2 - 9.6e-106 353.9 0.5 1.1e-105 353.7 0.5 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit PGK PF00162.17 001135738.1_39724001_3 - 2.1e-150 500.8 0.3 2.4e-150 500.6 0.3 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase DUF3172 PF11371.6 001135738.1_39724001_3 - 0.096 12.3 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3172) ATP-gua_Ptrans PF00217.17 001132908.1_43523001_3 - 2.7e-93 312.0 0.0 3.4e-93 311.6 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.13 001132908.1_43523001_3 - 1e-32 112.2 0.0 1.7e-32 111.5 0.0 1.4 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain Trypsin PF00089.24 001131588.1_43526001_3 - 9.1e-39 133.4 0.0 1.4e-38 132.8 0.0 1.2 1 0 0 1 1 1 1 Trypsin CUB PF00431.18 001131588.1_43526001_3 - 6.7e-24 84.2 0.0 1.5e-23 83.1 0.0 1.6 1 0 0 1 1 1 1 CUB domain Sushi PF00084.18 001131588.1_43526001_3 - 1.3e-17 64.1 3.8 2.2e-09 37.7 0.7 2.9 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) EGF PF00008.25 001131588.1_43526001_3 - 1.5e-07 31.4 4.4 1.5e-07 31.4 4.4 3.6 3 0 0 3 3 3 1 EGF-like domain hEGF PF12661.5 001131588.1_43526001_3 - 0.00013 22.4 1.5 0.00013 22.4 1.5 3.5 2 0 0 2 2 2 1 Human growth factor-like EGF DUF1986 PF09342.9 001131588.1_43526001_3 - 0.013 15.8 0.2 0.044 14.0 0.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF1986) Peptidase_M24 PF00557.22 001133947.1_43526001_2 - 1.6e-54 184.7 0.0 2.1e-54 184.3 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.14 001133947.1_43526001_2 - 6.9e-37 125.8 0.0 1.1e-36 125.1 0.0 1.3 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain AP3D1 PF06375.9 001132251.1_43528001_2 - 2.8 8.1 13.0 5.4 7.1 13.0 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 TSGP1 PF07771.9 001132251.1_43528001_2 - 4 7.5 10.6 7.5 6.6 10.6 1.4 1 0 0 1 1 1 0 Tick salivary peptide group 1 G-gamma PF00631.20 001132251.1_43528001_3 - 9.5e-18 63.8 0.0 1.7e-17 63.0 0.0 1.4 1 0 0 1 1 1 1 GGL domain SR-25 PF10500.7 001132251.1_43528001_3 - 5.4 6.4 19.2 11 5.4 19.2 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RabGAP-TBC PF00566.16 001132219.1_43529001_2 - 2.5e-57 193.9 1.5 2.5e-57 193.9 1.5 2.3 3 0 0 3 3 3 1 Rab-GTPase-TBC domain DUF3694 PF12473.6 001132219.1_43529001_2 - 1.1e-34 120.1 0.0 3.8e-34 118.4 0.0 2.0 1 0 0 1 1 1 1 Kinesin protein PID PF00640.21 001132219.1_43529001_2 - 0.00011 22.1 0.0 0.00011 22.1 0.0 2.8 3 0 0 3 3 3 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.11 001132219.1_43529001_2 - 0.0033 17.4 0.2 0.016 15.2 0.0 2.2 2 1 0 2 2 2 1 Phosphotyrosine-binding domain ERM PF00769.17 001132219.1_43529001_2 - 1 9.0 54.1 0.078 12.7 47.3 2.3 2 1 1 3 3 3 0 Ezrin/radixin/moesin family DUF3452 PF11934.6 001132219.1_43529001_2 - 3.4 7.1 11.2 3.1 7.2 0.5 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF3452) LIM PF00412.20 001133722.1_43525001_2 - 4.4e-33 113.2 34.1 1.2e-15 57.3 7.0 3.4 3 0 0 3 3 3 3 LIM domain ubiquitin PF00240.21 001135606.1_39725001_1 - 0 1101.1 52.4 2.2e-33 113.7 0.3 10.0 10 0 0 10 10 10 10 Ubiquitin family Rad60-SLD PF11976.6 001135606.1_39725001_1 - 2.9e-162 526.7 54.5 1.8e-15 56.4 0.4 10.0 10 0 0 10 10 10 10 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 001135606.1_39725001_1 - 3.6e-60 200.3 25.1 0.0004 20.6 0.1 12.4 10 10 0 10 10 10 10 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 001135606.1_39725001_1 - 3.9e-31 107.3 19.5 0.32 11.0 0.0 11.1 10 0 0 10 10 10 10 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 001135606.1_39725001_1 - 5.9e-28 97.3 7.0 1.9 9.0 0.0 10.2 1 1 2 10 10 10 10 DUF2407 ubiquitin-like domain DUF2870 PF11069.6 001135606.1_39725001_1 - 5.9e-17 61.7 0.0 39 4.6 0.0 10.7 10 0 0 10 10 10 0 Protein of unknown function (DUF2870) RBD PF02196.13 001135606.1_39725001_1 - 1.6e-13 50.4 0.0 72 3.5 0.0 10.1 10 0 0 10 10 10 0 Raf-like Ras-binding domain DUF969 PF06149.10 001135606.1_39725001_1 - 2.5e-11 43.3 1.1 51 3.1 0.0 9.5 10 0 0 10 10 10 0 Protein of unknown function (DUF969) ORF11CD3 PF10549.7 001135606.1_39725001_1 - 4.6e-08 32.9 0.0 2.5e+02 1.7 0.0 9.7 10 0 0 10 10 10 0 ORF11CD3 domain DUF3861 PF12977.5 001135606.1_39725001_1 - 9.2e-08 32.0 10.5 1.4e+02 2.6 0.0 9.8 10 0 0 10 10 10 0 Domain of Unknown Function with PDB structure (DUF3861) FERM_f0 PF16511.3 001135606.1_39725001_1 - 1.4e-05 25.2 37.7 92 3.3 0.1 16.1 10 10 0 10 10 10 0 N-terminal or F0 domain of Talin-head FERM FlgD_ig PF13860.4 001135606.1_39725001_1 - 4.7e-05 23.0 23.4 89 2.9 0.0 10.0 10 0 0 10 10 10 0 FlgD Ig-like domain TraK PF06586.9 001135606.1_39725001_1 - 0.00047 19.8 8.7 2.5e+02 1.0 0.0 8.8 10 0 0 10 10 10 0 TraK protein CorA PF01544.16 001135606.1_39725001_1 - 0.041 13.1 12.4 2.4e+02 0.7 0.0 8.5 10 0 0 10 10 10 0 CorA-like Mg2+ transporter protein ProRS-C_2 PF09181.8 001135606.1_39725001_1 - 0.24 11.4 19.2 3.4e+02 1.3 0.0 9.1 10 0 0 10 10 10 0 Prolyl-tRNA synthetase, C-terminal RNA_pol_Rpc4 PF05132.12 001133999.1_43522001_1 - 0.14 12.5 19.4 0.2 12.0 19.4 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 EOS1 PF12326.6 001133999.1_43522001_1 - 0.27 11.0 6.8 0.35 10.7 6.8 1.3 1 0 0 1 1 1 0 N-glycosylation protein Neur_chan_memb PF02932.14 001133999.1_43522001_1 - 0.54 10.2 5.9 0.62 9.9 5.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DDHD PF02862.15 001133999.1_43522001_1 - 0.84 9.6 10.4 1 9.3 10.4 1.1 1 0 0 1 1 1 0 DDHD domain RNA_polI_A34 PF08208.9 001133999.1_43522001_1 - 4.6 7.2 59.9 8.8 6.2 59.9 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF3807 PF12720.5 001133999.1_43522001_1 - 4.7 7.3 27.5 7.1 6.8 27.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Tim54 PF11711.6 001133999.1_43522001_1 - 5.2 5.6 22.7 6.4 5.3 22.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SRP-alpha_N PF04086.11 001133999.1_43522001_1 - 6.1 6.5 32.7 8.7 6.0 32.7 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal G0-G1_switch_2 PF15103.4 001133999.1_43522001_1 - 9.7 6.5 18.5 20 5.6 18.5 1.5 1 0 0 1 1 1 0 G0/G1 switch protein 2 RNA_pol_Rpc4 PF05132.12 001133999.1_43522001_2 - 0.0018 18.6 10.8 0.0021 18.4 10.8 1.2 1 0 0 1 1 1 1 RNA polymerase III RPC4 Coilin_N PF15862.3 001133999.1_43522001_2 - 0.38 10.4 30.9 0.61 9.7 30.9 1.3 1 0 0 1 1 1 0 Coilin N-terminus MCM_bind PF09739.7 001133999.1_43522001_2 - 0.85 7.9 12.5 1 7.6 12.5 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DDHD PF02862.15 001133999.1_43522001_2 - 1.7 8.5 10.0 2.1 8.3 10.0 1.1 1 0 0 1 1 1 0 DDHD domain Neur_chan_memb PF02932.14 001133999.1_43522001_2 - 5.2 6.9 7.3 5.9 6.7 7.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF1510 PF07423.9 001133999.1_43522001_2 - 7.6 5.8 23.1 9.6 5.4 23.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) FLO_LFY PF01698.14 001133999.1_43522001_2 - 8.4 5.4 12.7 12 4.8 12.7 1.2 1 0 0 1 1 1 0 Floricaula / Leafy protein Presenilin PF01080.15 001133999.1_43522001_2 - 8.5 4.9 12.5 11 4.6 12.5 1.1 1 0 0 1 1 1 0 Presenilin GST_C_3 PF14497.4 001133999.1_43522001_3 - 1.2e-15 57.4 0.0 1.2e-15 57.4 0.0 2.9 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 001133999.1_43522001_3 - 7.8e-14 51.5 0.0 7.8e-14 51.5 0.0 3.2 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.18 001133999.1_43522001_3 - 4.1e-06 26.9 0.0 4.1e-06 26.9 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.4 001133999.1_43522001_3 - 0.0057 16.5 0.0 0.013 15.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain EOS1 PF12326.6 001133999.1_43522001_3 - 0.017 14.9 1.2 0.021 14.6 1.2 1.2 1 0 0 1 1 1 0 N-glycosylation protein wnt PF00110.17 001135848.1_39725001_2 - 2e-121 405.1 25.2 2.4e-121 404.8 25.2 1.1 1 0 0 1 1 1 1 wnt family WD40 PF00400.30 001131697.2_43526001_1 - 1.9e-60 199.2 13.3 1.4e-08 35.1 0.2 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001131697.2_43526001_1 - 1.6e-21 76.3 0.0 0.0012 18.9 0.0 7.0 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.3 001131697.2_43526001_1 - 1.9e-10 40.1 0.4 0.079 11.8 0.0 5.4 1 1 3 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.6 001131697.2_43526001_1 - 1.6e-05 23.6 5.3 1.1 7.6 0.0 4.9 2 2 2 5 5 5 2 Nucleoporin Nup120/160 WD40_like PF17005.3 001131697.2_43526001_1 - 0.0001 21.6 0.0 0.68 9.1 0.0 3.1 2 1 1 3 3 3 2 WD40-like domain AAA_23 PF13476.4 001131697.2_43526001_2 - 5.2 7.4 24.8 8.1 6.8 24.8 1.2 1 0 0 1 1 1 0 AAA domain PCI PF01399.25 001132942.1_43525001_3 - 2.4e-05 24.7 0.2 0.0001 22.6 0.0 1.9 2 0 0 2 2 2 1 PCI domain MHC_I PF00129.16 001129198.1_39723001_2 - 2.5e-90 300.7 0.4 3.6e-90 300.2 0.4 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001129198.1_39723001_2 - 3.8e-17 62.4 0.0 7.9e-17 61.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.3 001129198.1_39723001_2 - 0.00024 20.5 0.0 0.00031 20.1 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain C2-set_2 PF08205.10 001129198.1_39723001_2 - 0.0015 18.5 0.1 0.003 17.4 0.1 1.5 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001129198.1_39723001_2 - 0.0017 18.4 0.0 0.005 16.8 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin domain MHC_I_C PF06623.9 001129198.1_39723001_2 - 0.12 12.2 0.1 0.21 11.4 0.1 1.4 1 0 0 1 1 1 0 MHC_I C-terminus Sod_Cu PF00080.18 001145185.1_39522001_2 - 7.5e-48 162.1 2.9 9.8e-48 161.8 2.9 1.1 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Cadherin PF00028.15 001013021.2_39727001_1 - 9.2e-76 250.3 0.0 2.7e-15 56.5 0.0 6.2 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001013021.2_39727001_1 - 1.6e-35 120.6 0.4 2.5e-33 113.6 0.0 3.4 4 0 0 4 4 4 1 Cadherin-like Cadherin_C_2 PF16492.3 001013021.2_39727001_1 - 1.4e-26 92.9 0.3 3.1e-26 91.9 0.3 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001013021.2_39727001_1 - 1.1e-06 28.5 0.7 0.043 13.7 0.0 4.6 4 0 0 4 4 4 1 Cadherin-like 7tm_1 PF00001.19 001122872.1_22423001_1 - 1.5e-79 266.9 10.9 1.9e-79 266.6 10.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001122872.1_22423001_1 - 3.5e-11 42.9 8.5 4.4e-10 39.2 8.5 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001122872.1_22423001_1 - 6.3e-06 26.0 7.9 0.00014 21.6 2.3 2.4 2 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001122872.1_22423001_1 - 6.9e-06 25.4 5.3 6.9e-06 25.4 5.3 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF3671 PF12420.6 001122872.1_22423001_1 - 6.3 6.8 7.1 19 5.2 0.3 3.0 3 0 0 3 3 3 0 Protein of unknown function Protamine_P1 PF00260.18 001173006.1_09921001_1 - 1.3e-07 31.5 69.5 1.7e-07 31.1 69.5 1.2 1 0 0 1 1 1 1 Protamine P1 DUF2650 PF10853.6 001173006.1_09921001_1 - 0.53 9.9 2.8 6.1 6.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2650) TT_ORF1 PF02956.12 001173006.1_09921001_1 - 7.9 4.9 31.3 9.2 4.7 31.3 1.0 1 0 0 1 1 1 0 TT viral orf 1 7tm_1 PF00001.19 001172887.1_09923001_1 - 8.4e-64 215.3 3.6 2.1e-63 213.9 3.6 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001172887.1_09923001_1 - 1.8e-08 33.9 0.0 1.3e-07 31.2 0.0 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001172887.1_09923001_1 - 4.3e-05 23.3 0.4 5.9e-05 22.8 0.4 1.2 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srv PF10323.7 001172887.1_09923001_1 - 0.0096 15.2 0.4 0.015 14.5 0.4 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.7 001172887.1_09923001_1 - 0.026 13.7 0.4 0.036 13.2 0.4 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx DUF2434 PF10361.7 001172887.1_09923001_1 - 0.77 8.6 3.9 3.9 6.3 3.9 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2434) DUF3673 PF12425.6 001172887.1_09923001_3 - 0.88 9.4 6.7 0.77 9.6 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3673) ACOX PF01756.17 001172906.1_09925001_1 - 3.2e-65 218.9 0.3 6.5e-65 217.9 0.3 1.5 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.4 001172906.1_09925001_1 - 2.6e-33 115.1 0.2 1.1e-32 113.1 0.0 2.1 3 0 0 3 3 3 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.17 001172906.1_09925001_1 - 1.5e-11 44.2 0.0 2.8e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.22 001172906.1_09925001_1 - 0.006 16.7 0.0 0.15 12.1 0.0 2.4 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain zf-U11-48K PF05253.10 028797.1_32922001_3 - 7.2e-20 70.3 10.2 4.1e-10 39.2 4.0 2.5 2 0 0 2 2 2 2 U11-48K-like CHHC zinc finger zf-TRAF_2 PF15965.3 028797.1_32922001_3 - 0.008 16.5 2.6 0.018 15.4 2.6 1.6 1 0 0 1 1 1 1 TRAF-like zinc-finger DUF4604 PF15377.4 001132045.1_43526001_2 - 9.8 6.5 20.7 14 6.0 20.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Peptidase_M24 PF00557.22 001132045.1_43526001_3 - 1.7e-51 174.7 0.1 2.4e-51 174.3 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.3 001132045.1_43526001_3 - 2.8e-20 72.2 8.2 7.8e-20 70.8 8.2 1.8 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.16 001132045.1_43526001_3 - 0.0023 17.9 4.8 0.0023 17.9 4.8 2.3 2 0 0 2 2 2 1 MYND finger Vinculin PF01044.17 001171142.1_37926001_1 - 0 1043.3 34.8 1.6e-215 718.4 24.7 2.1 1 1 1 2 2 2 2 Vinculin family Rotamase PF00639.19 001171142.1_37926001_1 - 0.46 11.3 10.5 3.3 8.6 0.1 5.1 5 0 0 5 5 5 0 PPIC-type PPIASE domain I_LWEQ PF01608.15 001171142.1_37926001_1 - 4.2 7.5 42.6 0.73 9.9 0.3 7.1 5 4 0 6 6 6 0 I/LWEQ domain CpXC PF14353.4 001135401.1_43527001_3 - 3.5e-06 26.9 7.4 0.022 14.7 0.0 3.7 3 1 0 3 3 3 2 CpXC protein zf-C2H2_4 PF13894.4 001135401.1_43527001_3 - 9.4e-06 25.9 41.5 0.012 16.3 2.5 7.2 7 0 0 7 7 7 4 C2H2-type zinc finger zf-C2H2 PF00096.24 001135401.1_43527001_3 - 1.7e-05 24.9 33.4 0.0017 18.6 2.3 6.2 7 0 0 7 7 7 3 Zinc finger, C2H2 type zf-BED PF02892.13 001135401.1_43527001_3 - 0.014 15.3 27.7 3.2 7.8 3.3 5.8 4 2 1 5 5 5 0 BED zinc finger zf-C2H2_jaz PF12171.6 001135401.1_43527001_3 - 0.019 15.2 16.1 0.021 15.0 1.3 5.1 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.3 001135401.1_43527001_3 - 0.023 15.0 21.4 0.54 10.6 4.1 5.0 4 2 0 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_2 PF12756.5 001135401.1_43527001_3 - 0.038 14.2 20.7 0.48 10.7 0.9 5.0 2 2 1 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_aberr PF17017.3 001135401.1_43527001_3 - 0.052 13.6 16.3 2.7 7.9 0.3 3.9 3 1 1 4 4 4 0 Aberrant zinc-finger zf-met PF12874.5 001135401.1_43527001_3 - 1.2 9.4 12.3 1.8 8.9 0.3 4.8 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zinc_ribbon_2 PF13240.4 001135401.1_43527001_3 - 1.8 8.3 8.2 15 5.3 0.4 3.6 3 0 0 3 3 3 0 zinc-ribbon domain PCI PF01399.25 001132681.1_43528001_1 - 3.4e-14 53.1 1.8 5.9e-14 52.3 1.1 1.8 2 0 0 2 2 2 1 PCI domain Death PF00531.20 001132681.1_43528001_1 - 0.53 10.4 2.2 1.1 9.4 0.1 2.2 2 0 0 2 2 2 0 Death domain DEAD PF00270.27 001172944.1_09924001_1 - 1.7e-42 145.1 2.6 2.8e-42 144.3 0.5 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.29 001172944.1_09924001_1 - 2.3e-28 98.7 0.3 3.3e-27 94.9 0.3 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.4 001172944.1_09924001_1 - 0.0005 19.4 0.1 0.00084 18.6 0.1 1.3 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.13 001172944.1_09924001_1 - 0.00075 19.4 0.0 0.0014 18.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.3 001172944.1_09924001_1 - 0.058 12.5 0.4 0.17 11.0 0.1 1.8 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase Glyco_hydro_15 PF00723.19 001165917.1_37929001_2 - 1.3e-196 653.6 0.0 1.6e-196 653.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Rhomboid PF01694.20 001133296.1_43523001_1 - 1.1e-29 103.3 14.7 2.6e-28 98.7 14.3 2.2 2 0 0 2 2 2 2 Rhomboid family adh_short_C2 PF13561.4 001130730.1_49822001_3 - 1.1e-61 208.2 1.3 1.4e-61 207.9 1.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.23 001130730.1_49822001_3 - 1.7e-50 171.1 0.5 2.1e-50 170.8 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.8 001130730.1_49822001_3 - 4e-16 59.3 1.3 7.2e-16 58.5 1.3 1.4 1 1 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.15 001130730.1_49822001_3 - 0.0027 16.7 0.5 0.0043 16.1 0.5 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.19 001130730.1_49822001_3 - 0.12 11.7 0.1 0.22 10.8 0.1 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family RNA_pol_Rpb1_4 PF05000.15 001130730.1_49822001_3 - 0.15 11.9 0.1 0.24 11.2 0.1 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 4 Reprolysin_2 PF13574.4 001130531.1_49825001_1 - 8.2e-35 120.3 0.1 2.2e-34 118.9 0.1 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.4 001130531.1_49825001_1 - 6.1e-32 111.2 0.6 1.2e-31 110.3 0.1 1.8 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.4 001130531.1_49825001_1 - 1.2e-28 100.0 0.0 2.3e-28 99.0 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.4 001130531.1_49825001_1 - 2.4e-16 59.9 0.1 4.3e-16 59.0 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.21 001130531.1_49825001_1 - 3e-14 53.4 32.6 3e-14 53.4 32.6 3.5 3 1 0 3 3 3 1 Disintegrin Pep_M12B_propep PF01562.17 001130531.1_49825001_1 - 2.2e-13 50.5 1.2 4.9e-13 49.4 1.2 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin PF01421.17 001130531.1_49825001_1 - 7.7e-08 32.3 0.6 5.6e-06 26.3 0.6 2.8 1 1 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Peptidase_M66 PF10462.7 001130531.1_49825001_1 - 0.027 13.3 0.2 0.049 12.4 0.2 1.3 1 0 0 1 1 1 0 Peptidase M66 UPF0370 PF13980.4 001130531.1_49825001_1 - 0.094 12.6 0.3 0.23 11.4 0.3 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0370) TLV_coat PF00429.17 001080784.2_39727001_2 - 1.2e-64 218.9 8.3 2.4e-61 208.0 5.5 2.2 2 0 0 2 2 2 2 ENV polyprotein (coat polyprotein) IncA PF04156.12 001080784.2_39727001_2 - 3.1 7.4 7.1 0.49 10.0 1.4 2.3 2 1 0 2 2 2 0 IncA protein p450 PF00067.20 001170926.1_37925001_3 - 2.8e-162 540.5 0.0 3.3e-162 540.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 7tm_1 PF00001.19 001172922.1_09923001_1 - 2.5e-41 141.6 23.8 9.1e-41 139.7 23.8 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) FA_desaturase PF00487.22 001172922.1_09923001_1 - 0.0041 16.9 1.4 0.0041 16.9 1.4 2.2 2 0 0 2 2 2 1 Fatty acid desaturase PSD5 PF07637.9 001172922.1_09923001_1 - 0.0068 16.6 0.0 0.017 15.3 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1595) 7TM_GPCR_Srw PF10324.7 001172922.1_09923001_1 - 0.012 14.8 1.6 0.015 14.5 0.5 1.7 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srw PDE6_gamma PF04868.10 001172996.1_09922001_3 - 6.8e-47 157.5 0.2 1.1e-46 156.9 0.2 1.3 1 0 0 1 1 1 1 Retinal cGMP phosphodiesterase, gamma subunit 7tm_1 PF00001.19 001172861.1_09924001_2 - 7.8e-58 195.7 24.4 1.2e-57 195.1 24.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001172861.1_09924001_2 - 0.005 16.5 22.2 0.013 15.2 22.2 1.8 1 1 0 1 1 1 1 Olfactory receptor TctB PF07331.9 001172861.1_09924001_2 - 0.07 13.3 15.7 0.024 14.7 6.0 2.4 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family p450 PF00067.20 001171265.1_37924001_3 - 7.8e-166 552.3 0.1 8.9e-166 552.1 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 zf-H2C2_2 PF13465.4 001145032.1_39726001_1 - 2.4e-64 210.9 115.6 1e-09 38.2 1.5 16.0 18 0 0 18 18 17 12 Zinc-finger double domain zf-C2H2 PF00096.24 001145032.1_39726001_1 - 5.5e-53 174.4 117.5 2.2e-05 24.5 0.3 13.8 14 0 0 14 14 14 12 Zinc finger, C2H2 type SCAN PF02023.15 001145032.1_39726001_1 - 5.2e-41 138.2 5.4 1.6e-40 136.7 5.4 1.9 1 0 0 1 1 1 1 SCAN domain zf-C2H2_4 PF13894.4 001145032.1_39726001_1 - 1.3e-23 81.4 114.7 0.0031 18.1 0.2 13.8 14 0 0 14 14 13 12 C2H2-type zinc finger KRAB PF01352.25 001145032.1_39726001_1 - 6.8e-14 51.1 0.0 1.8e-13 49.8 0.0 1.7 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 001145032.1_39726001_1 - 3.6e-10 39.4 91.8 0.013 15.3 0.1 14.4 14 0 0 14 14 14 8 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001145032.1_39726001_1 - 2.2e-06 27.5 56.1 0.015 15.3 1.8 8.7 5 3 3 8 8 8 6 Zinc ribbon domain zf-C2H2_11 PF16622.3 001145032.1_39726001_1 - 0.001 18.7 12.6 0.0024 17.5 1.1 11.5 12 0 0 12 12 12 3 zinc-finger C2H2-type zinc_ribbon_15 PF17032.3 001145032.1_39726001_1 - 0.0023 18.5 49.4 1.7 9.3 2.0 7.8 3 3 5 8 8 8 4 zinc-ribbon family ADK_lid PF05191.12 001145032.1_39726001_1 - 0.017 15.0 38.7 0.19 11.6 1.4 8.7 6 2 3 9 9 9 0 Adenylate kinase, active site lid DUF3268 PF11672.6 001145032.1_39726001_1 - 0.065 13.4 37.0 1.2 9.4 1.0 6.4 6 0 0 6 6 6 0 zinc-finger-containing domain BHD_1 PF10403.7 001145032.1_39726001_1 - 0.079 12.7 1.7 3.3 7.5 0.0 4.1 4 2 0 4 4 4 0 Rad4 beta-hairpin domain 1 zf-C2H2_jaz PF12171.6 001145032.1_39726001_1 - 0.42 10.9 47.6 15 5.9 0.1 11.1 11 0 0 11 11 11 0 Zinc-finger double-stranded RNA-binding FYVE PF01363.19 001145032.1_39726001_1 - 0.57 10.2 63.1 0.64 10.1 7.9 8.1 3 3 3 6 6 6 0 FYVE zinc finger Translin PF01997.14 001131907.2_43524001_1 - 2.6e-60 203.8 0.1 3.3e-60 203.4 0.1 1.1 1 0 0 1 1 1 1 Translin family Neur_chan_LBD PF02931.21 001168328.1_29624001_1 - 2.4e-50 170.8 0.1 6.3e-50 169.5 0.0 1.7 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 001168328.1_29624001_1 - 6.6e-49 167.0 0.0 8.6e-49 166.6 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF2070 PF09843.7 001168328.1_29624001_1 - 1.5 6.9 4.9 2.1 6.4 4.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) p450 PF00067.20 001170859.1_37925001_1 - 1.9e-145 485.0 0.0 2.2e-145 484.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 RnaseA PF00074.18 001167656.1_49822001_3 - 2.7e-41 140.8 5.1 3.8e-41 140.3 5.1 1.2 1 0 0 1 1 1 1 Pancreatic ribonuclease KASH PF10541.7 001167656.1_49822001_3 - 0.23 11.6 0.1 0.23 11.6 0.1 3.4 4 0 0 4 4 4 0 Nuclear envelope localisation domain UCH PF00443.27 001133175.1_43529001_2 - 2.3e-60 204.1 0.0 8.9e-60 202.2 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.10 001133175.1_43529001_2 - 2.5e-26 92.0 0.3 2.6e-16 59.9 0.0 2.6 2 0 0 2 2 2 2 DUSP domain UCH_1 PF13423.4 001133175.1_43529001_2 - 1.9e-22 80.2 0.0 2.3e-21 76.6 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.17 001133175.1_43529001_2 - 2.8e-15 56.3 5.8 2.8e-15 56.3 5.8 2.5 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein CDC45 PF02724.12 001133175.1_43529001_2 - 0.72 8.0 2.8 1 7.5 2.8 1.1 1 0 0 1 1 1 0 CDC45-like protein 7tm_1 PF00001.19 001172751.1_09923001_1 - 3.4e-72 242.8 10.7 4.7e-72 242.3 10.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001172751.1_09923001_1 - 7.1e-07 28.7 14.8 1.4e-06 27.7 14.8 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.7 001172751.1_09923001_1 - 1.1e-06 28.1 14.6 2e-06 27.3 14.2 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001172751.1_09923001_1 - 6.8e-05 22.6 14.1 0.0017 18.0 14.1 2.2 1 1 0 1 1 1 1 Olfactory receptor GDNF PF02351.14 001131461.1_43528001_2 - 6.2e-43 145.5 46.2 1.1e-23 83.8 4.2 3.6 3 0 0 3 3 3 3 GDNF/GAS1 domain DUF4131 PF13567.4 001131461.1_43528001_2 - 1.2 8.6 4.6 2.1 7.8 4.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) An_peroxidase PF03098.13 001173007.1_09926001_3 - 1.5e-53 182.0 0.1 6.7e-46 156.8 0.0 2.3 1 1 1 2 2 2 2 Animal haem peroxidase EGF PF00008.25 001173007.1_09926001_3 - 1.4e-05 25.2 12.5 3e-05 24.1 12.5 1.6 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.5 001173007.1_09926001_3 - 0.16 12.6 3.6 0.44 11.2 3.6 1.8 1 0 0 1 1 1 0 Human growth factor-like EGF WD40 PF00400.30 001133192.1_43527001_3 - 1.3e-40 136.5 21.9 5.5e-08 33.2 0.0 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001133192.1_43527001_3 - 2.5e-14 53.2 0.0 0.0013 18.9 0.0 5.4 1 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 001133192.1_43527001_3 - 0.0002 20.7 0.0 0.0015 17.8 0.0 2.1 1 1 1 2 2 2 2 WD40-like domain CALM_bind PF16025.3 001133192.1_43527001_3 - 0.11 12.8 1.5 0.31 11.4 1.5 1.6 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding Insulin PF00049.16 001122774.1_39722001_1 - 3.6e-20 72.6 2.5 7e-20 71.7 2.5 1.5 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family Ins_beta PF03488.12 001122774.1_39722001_1 - 0.011 15.6 3.3 1.8 8.5 0.5 2.3 2 0 0 2 2 2 0 Nematode insulin-related peptide beta type ETRAMP PF09716.8 001134219.1_43524001_1 - 0.0017 18.2 1.6 0.0017 18.2 1.6 1.8 2 0 0 2 2 2 1 Malarial early transcribed membrane protein (ETRAMP) adh_short PF00106.23 001134219.1_43524001_3 - 4.7e-49 166.4 0.3 6.1e-49 166.0 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001134219.1_43524001_3 - 1.8e-30 106.1 0.0 2.4e-30 105.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001134219.1_43524001_3 - 4.7e-08 33.0 0.2 7e-08 32.5 0.2 1.2 1 0 0 1 1 1 1 KR domain MHC_I_3 PF16497.3 001172851.1_09922001_1 - 1.4e-73 246.5 0.0 1.8e-73 246.1 0.0 1.1 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001172851.1_09922001_1 - 4.6e-11 42.9 0.1 9.5e-11 41.9 0.0 1.5 2 0 0 2 2 2 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001172851.1_09922001_1 - 3.8e-05 23.2 0.0 6.6e-05 22.4 0.0 1.4 1 1 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Ig_2 PF13895.4 001172851.1_09922001_1 - 0.011 15.9 0.0 0.02 15.1 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain DC_STAMP PF07782.11 001172851.1_09922001_1 - 0.13 11.9 0.2 7 6.3 0.0 2.2 2 0 0 2 2 2 0 DC-STAMP-like protein DUF4381 PF14316.4 001172851.1_09922001_1 - 0.32 11.1 1.1 0.72 10.0 1.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Porin_3 PF01459.20 001134043.1_43523001_2 - 3.2e-82 275.9 6.7 3.9e-82 275.6 6.7 1.1 1 0 0 1 1 1 1 Eukaryotic porin Connexin PF00029.17 001134043.1_43523001_3 - 2.4 7.7 7.5 3.4 7.2 7.5 1.2 1 0 0 1 1 1 0 Connexin ig PF00047.23 001132480.1_43529001_1 - 7.2e-08 32.4 0.0 1.5e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001132480.1_43529001_1 - 2.6e-05 24.0 0.0 4.8e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001132480.1_43529001_1 - 3e-05 24.4 0.0 5.8e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 001132480.1_43529001_1 - 0.01 15.8 0.2 0.34 10.9 0.2 2.3 1 1 0 1 1 1 0 Immunoglobulin V-set domain IL8 PF00048.18 001172926.1_09922001_2 - 5.8e-22 77.5 2.2 5.8e-22 77.5 2.2 1.7 2 0 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like XPG_N PF00752.15 001166196.1_39523001_1 - 4.1e-38 129.8 0.0 8.4e-38 128.8 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.16 001166196.1_39523001_1 - 1.4e-30 105.3 0.0 3e-30 104.3 0.0 1.6 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.18 001166196.1_39523001_1 - 2.2e-07 31.2 0.0 6.8e-07 29.7 0.0 1.8 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.4 001166196.1_39523001_1 - 0.04 14.4 0.0 0.097 13.2 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain TFIIS_C PF01096.16 213567.2_45722001_2 - 4.4e-15 55.1 4.4 4.4e-15 55.1 4.4 3.0 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) DZR PF12773.5 213567.2_45722001_2 - 6.6e-05 22.7 5.5 0.0047 16.8 0.4 2.4 2 0 0 2 2 2 2 Double zinc ribbon OrfB_Zn_ribbon PF07282.9 213567.2_45722001_2 - 0.00036 20.3 6.0 0.0055 16.5 0.1 2.4 2 1 0 2 2 2 1 Putative transposase DNA-binding domain Zn_Tnp_IS1595 PF12760.5 213567.2_45722001_2 - 0.0069 16.2 7.4 0.74 9.7 1.5 3.2 3 0 0 3 3 3 1 Transposase zinc-ribbon domain A2L_zn_ribbon PF08792.8 213567.2_45722001_2 - 0.0089 15.6 9.8 1.7 8.3 0.1 4.1 4 0 0 4 4 4 1 A2L zinc ribbon domain DUF3716 PF12511.6 213567.2_45722001_2 - 0.011 15.7 1.2 0.011 15.7 1.2 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3716) zf-ribbon_3 PF13248.4 213567.2_45722001_2 - 0.026 13.8 13.3 1.2 8.5 0.6 3.8 4 0 0 4 4 4 0 zinc-ribbon domain RNA_POL_M_15KD PF02150.14 213567.2_45722001_2 - 0.027 14.2 0.3 0.027 14.2 0.3 2.9 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit IBR PF01485.19 213567.2_45722001_2 - 0.028 14.5 0.2 0.028 14.5 0.2 2.9 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain Methyltransf_13 PF08421.9 213567.2_45722001_2 - 0.031 14.4 2.4 3 8.0 0.2 3.3 3 0 0 3 3 3 0 Putative zinc binding domain zinc_ribbon_2 PF13240.4 213567.2_45722001_2 - 0.048 13.2 14.1 0.12 11.9 3.0 3.8 3 1 0 3 3 3 0 zinc-ribbon domain UPF0547 PF10571.7 213567.2_45722001_2 - 0.059 13.3 10.7 5.8 7.0 5.9 3.5 2 1 1 3 3 3 0 Uncharacterised protein family UPF0547 HypA PF01155.17 213567.2_45722001_2 - 0.35 10.8 3.4 4.3 7.2 0.1 2.2 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-NADH-PPase PF09297.9 213567.2_45722001_2 - 0.48 10.0 10.9 7.1 6.3 1.5 3.4 3 0 0 3 3 3 0 NADH pyrophosphatase zinc ribbon domain zf-FPG_IleRS PF06827.12 213567.2_45722001_2 - 0.53 10.1 8.3 0.24 11.1 1.1 2.7 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS MqsA_antitoxin PF15731.3 213567.2_45722001_2 - 0.73 9.8 3.1 23 5.0 0.6 2.8 2 1 1 3 3 3 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA DNA_RNApol_7kD PF03604.11 213567.2_45722001_2 - 0.81 9.3 10.7 0.26 10.9 0.3 3.1 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit zinc_ribbon_4 PF13717.4 213567.2_45722001_2 - 1.3 8.9 9.6 12 5.8 0.3 4.0 4 0 0 4 4 4 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.10 213567.2_45722001_2 - 2.8 7.4 14.4 2 7.9 0.3 4.3 4 1 1 5 5 5 0 TFIIB zinc-binding zinc_ribbon_15 PF17032.3 213567.2_45722001_2 - 3.2 8.4 8.5 32 5.2 0.2 3.3 2 1 0 2 2 2 0 zinc-ribbon family DNA_ligase_ZBD PF03119.14 213567.2_45722001_2 - 4.5 7.3 7.8 7.2 6.6 0.3 3.5 2 1 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain Zn_ribbon_recom PF13408.4 213567.2_45722001_2 - 4.6 7.7 9.7 18 5.8 3.5 3.0 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain PhnA_Zn_Ribbon PF08274.10 213567.2_45722001_2 - 5 7.0 8.6 1 9.2 0.2 3.0 3 1 0 3 3 3 0 PhnA Zinc-Ribbon C1_2 PF03107.14 213567.2_45722001_2 - 8.2 6.7 11.4 44 4.4 0.3 3.3 2 2 0 2 2 2 0 C1 domain Mu-like_Com PF10122.7 213567.2_45722001_2 - 8.6 5.8 7.2 2.9 7.3 1.8 2.4 2 1 0 2 2 2 0 Mu-like prophage protein Com Zn-ribbon_8 PF09723.8 213567.2_45722001_2 - 9.7 6.3 15.2 8.2 6.5 0.3 3.8 2 2 2 4 4 4 0 Zinc ribbon domain FHA PF00498.24 001123138.1_49829001_1 - 6.2e-10 39.2 0.0 1.2e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 FHA domain RTT107_BRCT_5 PF16770.3 001123138.1_49829001_1 - 2.6e-07 30.3 0.0 5.1e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT PF00533.24 001123138.1_49829001_1 - 3.4e-05 24.0 0.0 0.028 14.7 0.0 2.3 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain Yop-YscD_cpl PF16697.3 001123138.1_49829001_1 - 0.14 12.4 0.0 0.33 11.2 0.0 1.6 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain Hormone_3 PF00159.16 001173005.1_09921001_1 - 1.1e-14 54.1 2.3 2e-14 53.2 2.3 1.5 1 0 0 1 1 1 1 Pancreatic hormone peptide IL8 PF00048.18 001172927.1_09922001_1 - 5.5e-21 74.4 1.4 8.2e-21 73.8 1.4 1.3 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Septin PF00735.16 001133994.1_43526001_1 - 4.5e-98 327.8 1.2 4.5e-98 327.8 1.2 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.21 001133994.1_43526001_1 - 1.4e-06 28.3 1.1 2.2e-06 27.6 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.11 001133994.1_43526001_1 - 0.0013 18.8 0.0 0.0033 17.5 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 001133994.1_43526001_1 - 0.0021 18.3 0.2 0.0048 17.2 0.0 1.6 2 0 0 2 2 1 1 AAA ATPase domain AAA_22 PF13401.4 001133994.1_43526001_1 - 0.0031 17.6 0.0 0.0077 16.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF3080 PF11279.6 001133994.1_43526001_1 - 0.0048 16.0 6.5 0.0072 15.4 6.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3080) Ras PF00071.20 001133994.1_43526001_1 - 0.0083 15.6 0.0 0.019 14.5 0.0 1.6 1 0 0 1 1 1 1 Ras family AAA_23 PF13476.4 001133994.1_43526001_1 - 0.017 15.5 19.9 0.29 11.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.4 001133994.1_43526001_1 - 0.035 13.7 0.0 0.066 12.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.25 001133994.1_43526001_1 - 0.059 12.8 6.2 2.8 7.3 0.2 3.2 3 1 0 3 3 3 0 Elongation factor Tu GTP binding domain RskA PF10099.7 001133994.1_43526001_1 - 0.34 11.1 3.2 0.6 10.3 3.2 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DUF258 PF03193.14 001133994.1_43526001_1 - 0.51 10.1 0.0 0.51 10.1 0.0 2.9 3 0 0 3 3 2 0 Protein of unknown function, DUF258 ABC_tran PF00005.25 001133994.1_43526001_1 - 0.86 10.0 4.0 0.89 9.9 0.0 2.3 2 0 0 2 2 2 0 ABC transporter Fzo_mitofusin PF04799.11 001133994.1_43526001_1 - 2.3 7.6 9.4 5 6.5 9.4 1.5 1 0 0 1 1 1 0 fzo-like conserved region Atg14 PF10186.7 001133994.1_43526001_1 - 8.5 5.2 19.7 12 4.8 19.0 1.4 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF87 PF01935.15 001133994.1_43526001_1 - 8.9 6.1 8.2 4.2 7.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF87 Connexin PF00029.17 001130038.1_39523001_1 - 1.2e-100 335.8 0.1 2e-100 335.1 0.1 1.3 1 0 0 1 1 1 1 Connexin Connexin50 PF03509.12 001130038.1_39523001_1 - 2.2e-30 105.1 0.5 2.2e-30 105.1 0.5 2.7 2 0 0 2 2 2 1 Gap junction alpha-8 protein (Cx50) Connexin40_C PF16791.3 001130038.1_39523001_1 - 0.00013 23.1 0.8 0.0002 22.4 0.0 1.8 2 0 0 2 2 2 1 Connexin 40 C-terminal domain Barttin PF15462.4 001130038.1_39523001_1 - 0.038 13.6 4.9 0.74 9.4 0.1 2.2 2 0 0 2 2 2 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) C1-set PF07654.13 001127618.2_37622001_1 - 3.3e-20 72.2 0.1 4.7e-20 71.7 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001127618.2_37622001_1 - 0.00034 21.0 0.1 0.00085 19.8 0.0 1.7 1 1 1 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.4 001127618.2_37622001_1 - 0.0019 18.4 0.1 0.0033 17.6 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001127618.2_37622001_1 - 0.04 13.9 0.1 0.076 13.1 0.1 1.5 1 0 0 1 1 1 0 Immunoglobulin domain C2-set_2 PF08205.10 001127618.2_37622001_1 - 0.043 13.8 0.1 0.073 13.0 0.1 1.3 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain I-set PF07679.14 001127618.2_37622001_1 - 0.043 13.8 0.0 0.066 13.2 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain 7tm_1 PF00001.19 001123100.1_49823001_1 - 1.7e-39 135.5 29.7 3.7e-39 134.4 29.7 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Pro_isomerase PF00160.19 001132964.1_43529001_1 - 1.6e-44 151.8 0.0 2.2e-44 151.4 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.20 001132964.1_43529001_1 - 3.3e-20 71.6 0.0 5.1e-20 70.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.4 001132964.1_43529001_1 - 0.0079 15.7 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4944 PF16302.3 001132964.1_43529001_1 - 0.17 11.8 0.0 0.29 11.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4944) TFIIIC_sub6 PF10419.7 001132964.1_43529001_2 - 0.027 14.2 0.0 1.5 8.6 0.0 2.4 2 0 0 2 2 2 0 TFIIIC subunit MHC_I_3 PF16497.3 001172850.1_09922001_1 - 3.6e-67 225.6 0.0 5.1e-67 225.1 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001172850.1_09922001_1 - 1.4e-10 41.4 0.1 3.2e-10 40.2 0.0 1.6 2 0 0 2 2 2 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001172850.1_09922001_1 - 0.012 15.1 0.0 0.021 14.3 0.0 1.5 1 1 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 Ig_3 PF13927.4 001172850.1_09922001_1 - 0.064 13.7 0.2 0.2 12.2 0.1 1.9 1 1 0 1 1 1 0 Immunoglobulin domain Enterotoxin_HS1 PF08090.9 001172850.1_09922001_2 - 0.014 15.2 3.0 0.037 13.9 3.0 1.6 1 0 0 1 1 1 0 Heat stable E.coli enterotoxin 1 PGM_PMM_I PF02878.14 001135524.2_43525001_2 - 1.2e-34 118.9 0.0 2.1e-34 118.1 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.14 001135524.2_43525001_2 - 3.8e-24 85.1 0.1 1e-23 83.8 0.1 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.14 001135524.2_43525001_2 - 1.4e-12 47.7 0.0 5.3e-12 45.8 0.0 2.0 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.18 001135524.2_43525001_2 - 4e-06 26.8 0.0 9.8e-06 25.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Costars PF14705.4 001135960.2_49823001_2 - 2e-31 107.9 0.0 3.3e-31 107.1 0.0 1.4 1 0 0 1 1 1 1 Costars ADH_zinc_N PF00107.24 001131990.1_43523001_3 - 7.2e-27 93.7 0.1 1.4e-26 92.8 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 001131990.1_43523001_3 - 3.5e-26 91.1 1.5 8.3e-26 89.9 1.5 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.4 001131990.1_43523001_3 - 0.00026 21.9 0.0 0.00049 21.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.12 001131990.1_43523001_3 - 0.002 17.6 0.1 0.0037 16.7 0.1 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.17 001131990.1_43523001_3 - 0.041 13.1 0.1 0.069 12.4 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.16 001131990.1_43523001_3 - 0.081 13.1 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain IL8 PF00048.18 001172824.1_09922001_3 - 1.2e-20 73.2 4.7 2.7e-20 72.1 4.7 1.6 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Caveolin PF01146.15 001135826.1_39727001_3 - 5.4e-56 188.1 1.1 8.4e-56 187.5 1.1 1.2 1 0 0 1 1 1 1 Caveolin UT PF03253.12 001163054.1_39523001_1 - 9.9e-111 369.4 33.3 1.1e-110 369.2 33.3 1.0 1 0 0 1 1 1 1 Urea transporter OHCU_decarbox PF09349.8 001039678.2_32922001_2 - 3.1e-39 134.8 0.0 4.1e-39 134.4 0.0 1.2 1 0 0 1 1 1 1 OHCU decarboxylase WD40 PF00400.30 001131816.1_43524001_1 - 3.3e-29 100.4 12.8 0.00012 22.6 0.1 8.2 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001131816.1_43524001_1 - 1.6e-16 60.2 0.1 0.0015 18.7 0.0 5.8 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 001131816.1_43524001_1 - 3.6e-05 23.6 0.0 0.026 14.2 0.0 2.9 3 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.4 001131816.1_43524001_1 - 0.00079 18.9 1.0 0.007 15.8 0.9 2.3 1 1 0 1 1 1 1 PQQ-like domain Ge1_WD40 PF16529.3 001131816.1_43524001_1 - 0.0017 17.3 0.0 0.071 11.9 0.0 3.0 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.3 001131816.1_43524001_1 - 0.0023 17.2 0.0 0.53 9.4 0.0 3.3 3 0 0 3 3 3 1 WD40-like domain Nup160 PF11715.6 001131816.1_43524001_1 - 0.0044 15.6 0.1 0.52 8.7 0.0 3.2 3 0 0 3 3 3 1 Nucleoporin Nup120/160 DUF5046 PF16465.3 001131816.1_43524001_1 - 0.025 13.9 0.1 0.9 8.8 0.0 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF5046) RAB3GAP2_N PF14655.4 001131816.1_43524001_1 - 0.12 11.5 0.0 0.48 9.4 0.0 2.0 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus PQQ PF01011.19 001131816.1_43524001_1 - 2.3 8.2 7.8 27 4.8 0.1 4.6 5 0 0 5 5 5 0 PQQ enzyme repeat 7tm_1 PF00001.19 001135622.1_39723001_1 - 5e-88 294.7 0.0 6e-88 294.4 0.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001135622.1_39723001_1 - 7e-13 48.4 4.0 9e-08 31.7 1.7 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001135622.1_39723001_1 - 4.9e-06 26.4 6.1 7.7e-05 22.4 1.4 2.8 3 0 0 3 3 3 2 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001135622.1_39723001_1 - 2.6e-05 23.6 2.2 2.6e-05 23.6 2.2 2.1 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx RabGGT_insert PF07711.9 001133624.1_43525001_1 - 7.7e-43 145.1 0.1 1.4e-42 144.3 0.1 1.4 1 0 0 1 1 1 1 Rab geranylgeranyl transferase alpha-subunit, insert domain PPTA PF01239.20 001133624.1_43525001_1 - 1.5e-41 138.9 17.1 1.1e-08 34.5 0.0 5.9 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat LRR_8 PF13855.4 001133624.1_43525001_1 - 4.6e-08 32.6 7.5 9.2e-05 22.0 0.8 2.8 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.5 001133624.1_43525001_1 - 5.3e-08 32.9 13.2 0.00012 22.2 0.2 4.5 3 1 3 6 6 6 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001133624.1_43525001_1 - 4e-06 26.3 1.1 4e-06 26.3 1.1 2.2 1 1 1 2 2 2 1 Leucine-rich repeat LRR_1 PF00560.31 001133624.1_43525001_1 - 0.024 14.9 4.8 2.8 8.6 0.0 4.7 4 0 0 4 4 4 0 Leucine Rich Repeat UNC45-central PF11701.6 001133911.1_43527001_3 - 6e-37 126.8 8.5 2.6e-35 121.5 0.0 4.8 5 0 0 5 5 5 1 Myosin-binding striated muscle assembly central TPR_2 PF07719.15 001133911.1_43527001_3 - 8.6e-13 47.2 12.2 0.00013 21.7 0.0 4.2 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_1 PF00515.26 001133911.1_43527001_3 - 6.1e-12 44.7 11.4 0.00098 18.7 0.3 4.0 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_8 PF13181.4 001133911.1_43527001_3 - 2.4e-08 33.4 9.1 0.0002 21.2 0.0 4.2 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_16 PF13432.4 001133911.1_43527001_3 - 3e-08 34.1 5.1 3.1e-05 24.4 1.2 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.4 001133911.1_43527001_3 - 3.9e-07 30.2 4.0 0.014 16.0 0.1 5.1 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.4 001133911.1_43527001_3 - 2.8e-06 27.6 6.5 0.00084 19.7 2.8 3.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.4 001133911.1_43527001_3 - 3.6e-06 26.8 0.6 0.077 13.3 0.0 3.4 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_11 PF13414.4 001133911.1_43527001_3 - 1.5e-05 24.5 2.3 0.0016 18.0 0.6 3.1 1 1 2 3 3 3 1 TPR repeat HEAT_2 PF13646.4 001133911.1_43527001_3 - 4.2e-05 23.7 11.8 0.24 11.7 0.0 6.5 4 2 2 6 6 6 1 HEAT repeats TPR_12 PF13424.4 001133911.1_43527001_3 - 6.3e-05 23.1 3.5 0.0025 18.0 2.4 3.0 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_9 PF13371.4 001133911.1_43527001_3 - 0.0004 20.3 2.1 0.045 13.8 0.2 3.3 1 1 2 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.5 001133911.1_43527001_3 - 0.0018 18.3 1.4 0.0058 16.7 1.4 2.0 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 Arm PF00514.21 001133911.1_43527001_3 - 0.0024 17.7 8.4 21 5.2 0.0 7.4 7 1 0 7 7 7 0 Armadillo/beta-catenin-like repeat TPR_7 PF13176.4 001133911.1_43527001_3 - 0.0027 17.5 1.8 1.1 9.3 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.4 001133911.1_43527001_3 - 0.1 13.1 9.1 0.12 12.9 0.1 4.2 5 0 0 5 5 2 0 Tetratricopeptide repeat RIX1 PF08167.10 001133911.1_43527001_3 - 0.31 10.6 6.4 0.22 11.1 0.2 3.0 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis Adaptin_N PF01602.18 001133911.1_43527001_3 - 2.2 6.6 5.3 4.6 5.5 0.1 3.1 3 2 0 3 3 3 0 Adaptin N terminal region HEAT PF02985.20 001133911.1_43527001_3 - 6.1 7.2 6.7 1.1e+02 3.3 0.0 6.0 6 0 0 6 6 5 0 HEAT repeat p450 PF00067.20 001171268.2_37924001_3 - 3.8e-135 451.1 0.4 4.4e-135 450.9 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 EF1G PF00647.17 001101703.1_37923001_2 - 3.5e-53 178.0 0.2 6.5e-53 177.2 0.2 1.5 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_N PF02798.18 001101703.1_37923001_2 - 3e-23 81.8 0.0 7.5e-23 80.5 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 001101703.1_37923001_2 - 1e-19 70.4 2.1 2.1e-19 69.4 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 001101703.1_37923001_2 - 4.7e-10 39.1 0.0 1.4e-09 37.6 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 001101703.1_37923001_2 - 6.6e-07 29.3 0.6 1.6e-06 28.1 0.0 2.1 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 001101703.1_37923001_2 - 2e-06 28.0 0.0 4.3e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 001101703.1_37923001_2 - 0.0015 18.7 0.0 0.0035 17.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain SAPS PF04499.13 001101703.1_37923001_2 - 0.17 10.5 0.2 0.23 10.1 0.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein NUC194 PF08163.10 001101703.1_37923001_2 - 0.18 10.9 0.9 0.63 9.1 0.4 1.9 2 0 0 2 2 2 0 NUC194 domain adh_short PF00106.23 001131734.1_43523001_3 - 8.9e-33 113.3 0.0 3.4e-26 91.8 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.4 001131734.1_43523001_3 - 6.7e-24 84.6 0.0 1.9e-17 63.5 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001131734.1_43523001_3 - 2.1e-07 30.9 0.0 3.3e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 KR domain Laminin_G_2 PF02210.22 001133793.1_43529001_2 - 5.6e-93 308.0 5.7 3.5e-24 85.7 0.2 4.3 4 0 0 4 4 4 4 Laminin G domain Laminin_G_1 PF00054.21 001133793.1_43529001_2 - 2.6e-64 215.2 0.6 8.2e-17 61.5 0.0 4.4 4 0 0 4 4 4 4 Laminin G domain F5_F8_type_C PF00754.23 001133793.1_43529001_2 - 2.5e-32 111.5 1.6 1.2e-31 109.3 1.0 2.6 3 0 0 3 3 3 1 F5/8 type C domain Laminin_G_3 PF13385.4 001133793.1_43529001_2 - 2.8e-11 43.7 0.3 0.001 19.1 0.0 3.6 3 0 0 3 3 3 2 Concanavalin A-like lectin/glucanases superfamily COLFI PF01410.16 001133793.1_43529001_2 - 2.4e-05 23.6 0.3 5.3e-05 22.5 0.3 1.6 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Syndecan PF01034.18 001133793.1_43529001_2 - 0.029 14.1 0.0 0.065 13.0 0.0 1.5 1 0 0 1 1 1 0 Syndecan domain MARVEL PF01284.21 001133793.1_43529001_2 - 0.15 12.0 0.1 0.44 10.5 0.0 1.8 2 0 0 2 2 2 0 Membrane-associating domain hEGF PF12661.5 001133793.1_43529001_2 - 3.8 8.2 30.9 0.086 13.4 1.6 4.5 4 0 0 4 4 4 0 Human growth factor-like EGF Copine PF07002.14 001133925.1_43529001_2 - 1.5e-91 305.6 0.0 2.1e-91 305.1 0.0 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.28 001133925.1_43529001_2 - 6.5e-28 96.9 0.2 2.3e-13 50.2 0.0 2.4 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.7 001133925.1_43529001_2 - 0.00011 22.2 0.0 0.0002 21.4 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus Lipocalin PF00061.21 001134614.1_45722001_1 - 4.4e-22 78.7 0.3 5.5e-22 78.4 0.3 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 001134614.1_45722001_1 - 2.6e-05 24.0 0.2 3.7e-05 23.5 0.2 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Thioredoxin PF00085.18 001171047.1_37925001_2 - 1e-66 221.3 0.2 3.6e-34 116.7 0.0 3.7 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.4 001171047.1_37925001_2 - 7.8e-46 156.2 2.2 1.2e-39 136.1 0.8 3.0 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_2 PF13098.4 001171047.1_37925001_2 - 1.9e-12 47.4 0.2 8.3e-06 26.1 0.0 3.0 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.4 001171047.1_37925001_2 - 1.7e-11 44.0 0.0 2.6e-05 24.2 0.0 3.1 3 0 0 3 3 3 2 Thioredoxin-like OST3_OST6 PF04756.11 001171047.1_37925001_2 - 4.7e-10 39.2 0.0 6e-06 25.7 0.0 3.1 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.4 001171047.1_37925001_2 - 8.2e-07 29.1 0.0 0.043 14.0 0.0 3.7 3 1 1 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.19 001171047.1_37925001_2 - 9.5e-07 28.6 0.4 0.021 14.6 0.0 3.4 2 1 0 3 3 3 2 AhpC/TSA family ERp29_N PF07912.11 001171047.1_37925001_2 - 1.7e-06 28.1 0.2 0.3 11.1 0.0 4.0 4 0 0 4 4 4 2 ERp29, N-terminal domain Calsequestrin PF01216.15 001171047.1_37925001_2 - 7.7e-06 25.0 1.5 1.5e-05 24.1 0.9 1.7 2 1 0 2 2 2 1 Calsequestrin Redoxin PF08534.8 001171047.1_37925001_2 - 8.2e-05 22.2 0.1 0.36 10.4 0.1 2.4 2 0 0 2 2 2 2 Redoxin Glutaredoxin PF00462.22 001171047.1_37925001_2 - 0.016 15.3 0.6 1.9 8.6 0.0 3.2 2 1 0 2 2 2 0 Glutaredoxin Thioredoxin_9 PF14595.4 001171047.1_37925001_2 - 0.034 13.8 0.0 5.9 6.5 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin TraF PF13728.4 001171047.1_37925001_2 - 0.042 13.5 0.0 3.6 7.2 0.0 2.3 2 0 0 2 2 2 0 F plasmid transfer operon protein HyaE PF07449.9 001171047.1_37925001_2 - 0.08 12.8 0.0 0.67 9.8 0.0 2.3 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Thioredoxin_5 PF13743.4 001171047.1_37925001_2 - 0.11 12.0 1.3 54 3.3 0.0 3.5 2 2 1 3 3 3 0 Thioredoxin GDP_Man_Dehyd PF16363.3 001132676.1_43524001_2 - 8.5e-57 192.9 0.0 1e-56 192.6 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.19 001132676.1_43524001_2 - 2e-50 171.4 0.0 2.6e-50 171.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.17 001132676.1_43524001_2 - 2.2e-16 59.5 0.0 5e-15 55.1 0.0 2.0 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.15 001132676.1_43524001_2 - 9.9e-11 41.1 0.0 1.7e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.13 001132676.1_43524001_2 - 8.9e-10 38.0 0.0 3.2e-09 36.2 0.0 2.0 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.10 001132676.1_43524001_2 - 6.4e-07 28.7 0.0 7.1e-05 22.0 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.4 001132676.1_43524001_2 - 7.7e-06 25.8 0.0 2.8e-05 24.0 0.0 1.9 1 1 0 1 1 1 1 NAD(P)H-binding KR PF08659.8 001132676.1_43524001_2 - 1.1e-05 25.3 0.0 1.9e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 KR domain NmrA PF05368.11 001132676.1_43524001_2 - 0.00036 20.0 0.0 0.023 14.1 0.0 2.3 2 0 0 2 2 2 1 NmrA-like family adh_short PF00106.23 001132676.1_43524001_2 - 0.0016 17.8 0.0 0.013 14.9 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase NAP PF00956.16 001133514.1_43525001_3 - 1.6e-110 368.3 5.2 2.6e-110 367.7 5.2 1.3 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) PGM_PMM_I PF02878.14 001132512.1_43528001_3 - 5.8e-34 116.6 0.0 1.2e-33 115.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.14 001132512.1_43528001_3 - 1e-23 83.8 0.0 3.4e-23 82.1 0.0 1.9 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.14 001132512.1_43528001_3 - 1.2e-12 47.8 0.1 2e-12 47.2 0.1 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.18 001132512.1_43528001_3 - 2.3e-07 30.7 0.0 6.2e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain 2-Hacid_dh_C PF02826.17 001123162.1_49824001_1 - 6e-57 191.7 0.0 1e-56 191.0 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.28 001123162.1_49824001_1 - 6.2e-39 132.6 0.0 8.4e-39 132.2 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Opiods_neuropep PF01160.16 001172997.1_09925001_1 - 4.3e-16 58.6 6.4 4.3e-16 58.6 6.4 2.3 2 0 0 2 2 2 1 Vertebrate endogenous opioids neuropeptide ADP_ribosyl_GH PF03747.12 001133826.1_43525001_3 - 6.1e-51 173.8 0.3 7.5e-51 173.4 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase 14-3-3 PF00244.18 001133850.1_43524001_3 - 1.8e-105 351.2 10.7 2.2e-105 350.9 10.7 1.1 1 0 0 1 1 1 1 14-3-3 protein DUF722 PF05263.9 001133850.1_43524001_3 - 0.083 13.0 0.4 0.17 12.0 0.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF722) Orbi_VP5 PF00901.15 001133850.1_43524001_3 - 0.35 9.1 2.3 0.55 8.4 2.3 1.1 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 Kelch_4 PF13418.4 001131634.1_43529001_2 - 2.6e-25 88.0 2.2 3.3e-07 30.0 0.0 5.6 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_3 PF13415.4 001131634.1_43529001_2 - 4.9e-23 80.7 7.5 4e-08 33.2 0.1 5.5 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.4 001131634.1_43529001_2 - 1.9e-19 69.1 5.4 1.6e-07 31.0 0.0 5.4 6 0 0 6 6 6 3 Kelch motif Kelch_1 PF01344.23 001131634.1_43529001_2 - 3e-16 58.6 0.6 2.9e-06 26.6 0.0 5.3 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.13 001131634.1_43529001_2 - 8.7e-16 57.1 10.8 3.1e-08 33.2 0.4 6.0 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.4 001131634.1_43529001_2 - 3e-14 52.6 10.4 0.00033 20.7 0.1 5.8 5 1 1 6 6 6 3 Kelch motif F-box-like PF12937.5 001131634.1_43529001_2 - 4.5e-09 35.9 0.0 1.3e-08 34.5 0.0 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001131634.1_43529001_2 - 5.4e-07 29.2 0.0 1.3e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 F-box domain ubiquitin PF00240.21 001173066.1_09922001_1 - 9.5e-35 118.0 0.3 1.7e-34 117.2 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.17 001173066.1_09922001_1 - 3.6e-28 97.3 4.2 7.1e-28 96.4 4.2 1.5 1 0 0 1 1 1 1 Ribosomal protein S27a Rad60-SLD PF11976.6 001173066.1_09922001_1 - 7.4e-17 60.8 0.4 1.4e-16 59.9 0.4 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 001173066.1_09922001_1 - 6.7e-06 26.3 0.3 3.4e-05 24.1 0.1 2.2 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 001173066.1_09922001_1 - 0.00017 21.5 0.8 0.00034 20.6 0.8 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 001173066.1_09922001_1 - 0.0077 16.7 0.6 0.011 16.2 0.6 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain IBR PF01485.19 001173066.1_09922001_1 - 0.063 13.4 4.2 0.1 12.7 4.2 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain UcrQ PF02939.14 001133345.1_43521001_2 - 3.9e-31 106.7 0.2 5e-31 106.3 0.2 1.1 1 0 0 1 1 1 1 UcrQ family Cyt_b-c1_8 PF10890.6 001133345.1_43521001_2 - 0.0056 16.9 0.0 0.0078 16.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b-c1 complex subunit 8 MHC_I_3 PF16497.3 001172853.1_09922001_1 - 3.1e-75 251.9 0.1 3.8e-75 251.6 0.1 1.1 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001172853.1_09922001_1 - 2.1e-10 40.8 0.0 4.4e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001172853.1_09922001_1 - 0.0044 16.5 0.0 0.0082 15.6 0.0 1.5 1 1 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 3HCDH_N PF02737.16 001172946.1_09927001_1 - 2e-57 193.8 0.3 2.8e-57 193.4 0.3 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.18 001172946.1_09927001_1 - 3.3e-41 141.1 0.0 9.7e-41 139.6 0.0 1.7 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase 3HCDH PF00725.20 001172946.1_09927001_1 - 5.3e-38 129.4 0.0 4.2e-27 94.5 0.0 2.5 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_2 PF16113.3 001172946.1_09927001_1 - 5.5e-25 88.4 0.0 1.1e-24 87.4 0.0 1.5 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase UDPG_MGDP_dh_N PF03721.12 001172946.1_09927001_1 - 0.00097 18.6 0.0 0.0016 17.9 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.16 001172946.1_09927001_1 - 0.0047 17.1 0.0 0.0088 16.2 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_2 PF03446.13 001172946.1_09927001_1 - 0.0077 16.3 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.17 001172946.1_09927001_1 - 0.014 14.7 0.0 0.023 13.9 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.15 001172946.1_09927001_1 - 0.017 15.6 0.1 0.039 14.4 0.1 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Peptidase_S49 PF01343.16 001172946.1_09927001_1 - 0.094 12.5 0.0 5 6.9 0.0 2.7 3 0 0 3 3 3 0 Peptidase family S49 zf-C2H2 PF00096.24 001135619.1_39729001_1 - 2e-48 160.1 71.0 0.0003 20.9 1.6 13.8 13 0 0 13 13 13 12 Zinc finger, C2H2 type SCAN PF02023.15 001135619.1_39729001_1 - 1.9e-31 107.6 2.4 2.5e-31 107.2 0.9 2.0 2 0 0 2 2 2 1 SCAN domain zf-C2H2_4 PF13894.4 001135619.1_39729001_1 - 7.6e-26 88.4 72.6 0.027 15.1 0.3 13.3 13 0 0 13 13 13 12 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001135619.1_39729001_1 - 1.1e-10 41.1 74.7 0.015 15.1 2.1 12.9 12 0 0 12 12 12 5 C2H2-type zinc finger zf-C2HC_2 PF13913.4 001135619.1_39729001_1 - 2.3e-09 36.8 28.7 0.14 11.9 0.1 9.5 9 0 0 9 9 9 4 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.6 001135619.1_39729001_1 - 0.00055 20.0 47.6 2.6 8.3 0.6 11.3 11 0 0 11 11 11 4 Zinc-finger double-stranded RNA-binding Zf_RING PF16744.3 001135619.1_39729001_1 - 0.0024 17.8 14.8 2.7 8.0 0.1 7.4 7 0 0 7 7 7 2 KIAA1045 RING finger zf-H2C2_2 PF13465.4 001135619.1_39729001_1 - 0.034 14.5 98.8 0.31 11.4 0.2 19.4 21 2 0 21 21 20 0 Zinc-finger double domain BolA PF01722.16 001135619.1_39729001_1 - 0.075 13.2 4.4 11 6.3 0.0 4.8 5 0 0 5 5 5 0 BolA-like protein zf-C2H2_8 PF15909.3 001135619.1_39729001_1 - 0.094 12.9 39.0 3.1 8.0 0.2 10.6 5 4 7 12 12 12 0 C2H2-type zinc ribbon Baculo_IE-1 PF05290.9 001135619.1_39729001_1 - 0.32 10.8 16.3 8.7 6.2 0.1 6.1 7 0 0 7 7 7 0 Baculovirus immediate-early protein (IE-0) zf-met PF12874.5 001135619.1_39729001_1 - 0.99 9.7 45.4 3.6 8.0 0.3 9.6 9 0 0 9 9 9 0 Zinc-finger of C2H2 type Lar_restr_allev PF14354.4 001135619.1_39729001_1 - 1.5 9.1 26.8 4.5 7.6 0.1 8.3 8 2 1 9 9 9 0 Restriction alleviation protein Lar DUF1077 PF06417.10 001131895.1_43523001_2 - 1.5e-45 153.9 3.5 2e-45 153.5 3.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) Ras PF00071.20 001133523.1_43525001_3 - 1.6e-53 180.5 0.2 2.2e-53 180.0 0.2 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001133523.1_43525001_3 - 6.6e-20 71.4 0.0 1.1e-19 70.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001133523.1_43525001_3 - 9.6e-09 34.8 0.0 1.5e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF258 PF03193.14 001133523.1_43525001_3 - 4.8e-08 33.0 0.2 0.00014 21.7 0.1 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001133523.1_43525001_3 - 0.0015 18.0 0.0 0.0033 16.9 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001133523.1_43525001_3 - 0.0086 16.0 0.0 0.014 15.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.10 001133523.1_43525001_3 - 0.015 14.5 0.0 0.021 14.0 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_25 PF13481.4 001133523.1_43525001_3 - 0.062 12.7 0.0 0.098 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain FCH PF00611.21 001131801.1_43525001_3 - 1.7e-17 63.3 1.4 1.1e-16 60.7 0.5 2.7 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.26 001131801.1_43525001_3 - 4.5e-08 32.4 0.0 8.8e-08 31.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 001131801.1_43525001_3 - 1.2e-06 28.2 0.0 2.1e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 001131801.1_43525001_3 - 0.00032 20.8 0.0 0.00075 19.6 0.0 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_2 PF07653.15 001131801.1_43525001_3 - 0.00048 19.6 0.0 0.00093 18.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Exonuc_VII_L PF02601.13 001131801.1_43525001_3 - 0.62 9.4 17.1 0.61 9.5 10.4 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF4446 PF14584.4 001131801.1_43525001_3 - 0.8 9.5 8.5 1.3 8.9 0.1 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF4446) ERM PF00769.17 001131801.1_43525001_3 - 1.9 8.1 29.1 4 7.1 2.7 2.3 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Lzipper-MIP1 PF14389.4 001131801.1_43525001_3 - 4.7 7.4 13.9 0.2 11.8 7.0 2.2 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 P16-Arc PF04699.12 001133468.1_43523001_1 - 6.3e-55 185.6 0.0 9.1e-55 185.1 0.0 1.2 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Utp12 PF04003.10 001133468.1_43523001_1 - 0.036 14.3 0.0 0.062 13.5 0.0 1.3 1 0 0 1 1 1 0 Dip2/Utp12 Family Mod_r PF07200.11 001132398.1_43526001_2 - 2.1e-35 121.8 10.7 2.7e-35 121.5 10.7 1.1 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein HLH PF00010.24 001132398.1_43526001_2 - 0.1 12.5 0.2 0.26 11.1 0.2 1.6 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain p450 PF00067.20 001172694.1_09924001_1 - 3.8e-103 345.6 0.0 4.7e-103 345.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF3810 PF12725.5 001172694.1_09924001_1 - 0.096 11.9 0.1 0.21 10.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Sec8_exocyst PF04048.12 001172694.1_09924001_1 - 0.1 12.4 1.1 0.19 11.5 1.1 1.4 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain Pkinase_Tyr PF07714.15 001135830.1_39729001_2 - 9e-93 310.2 0.0 1.3e-92 309.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Sema PF01403.17 001135830.1_39729001_2 - 4e-56 190.5 2.6 6e-56 189.9 2.6 1.2 1 0 0 1 1 1 1 Sema domain TIG PF01833.22 001135830.1_39729001_2 - 2.1e-40 136.6 12.9 9.9e-14 51.1 0.9 4.7 4 0 0 4 4 4 4 IPT/TIG domain Pkinase PF00069.23 001135830.1_39729001_2 - 1.3e-39 136.1 0.0 2.2e-39 135.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain PSI PF01437.23 001135830.1_39729001_2 - 1.5e-05 25.3 15.5 9.7e-05 22.7 15.5 2.5 1 0 0 1 1 1 1 Plexin repeat Kinase-like PF14531.4 001135830.1_39729001_2 - 0.00034 19.9 0.0 0.00058 19.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like PSI_integrin PF17205.1 001135830.1_39729001_2 - 3.4 7.4 11.3 16 5.3 11.3 2.1 1 0 0 1 1 1 0 Integrin plexin domain Cadherin PF00028.15 001171046.1_37926001_2 - 7.9e-60 199.2 0.0 1.4e-11 44.5 0.0 6.4 6 0 0 6 6 6 6 Cadherin domain Cadherin_3 PF16184.3 001171046.1_37926001_2 - 0.0012 18.7 0.0 5.4 6.9 0.0 3.7 3 0 0 3 3 3 1 Cadherin-like Cadherin_2 PF08266.10 001171046.1_37926001_2 - 0.0034 17.0 0.0 1.3 8.8 0.0 3.5 3 0 0 3 3 3 1 Cadherin-like He_PIG PF05345.10 001171046.1_37926001_2 - 1 9.5 5.4 36 4.5 1.8 4.9 4 1 0 4 4 4 0 Putative Ig domain bZIP_1 PF00170.19 001132487.1_43525001_3 - 2.8e-12 46.4 7.9 4.2e-12 45.8 7.9 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.13 001132487.1_43525001_3 - 1.3e-08 34.7 8.1 2.2e-08 33.9 8.1 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.15 001132487.1_43525001_3 - 0.00054 20.3 7.7 0.001 19.4 7.7 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor zf-C2H2 PF00096.24 001132487.1_43525001_3 - 0.0031 17.7 1.1 0.0078 16.5 1.1 1.7 1 0 0 1 1 1 1 Zinc finger, C2H2 type Cnn_1N PF07989.9 001132487.1_43525001_3 - 0.05 13.6 1.7 0.085 12.9 1.7 1.3 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 MHC_I PF00129.16 001171270.1_37923001_1 - 4.6e-92 306.3 3.7 6.2e-92 305.9 3.7 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001171270.1_37923001_1 - 1.1e-16 60.9 0.0 2.3e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001171270.1_37923001_1 - 7.1e-07 28.9 1.4 1.9e-06 27.5 1.4 1.7 1 0 0 1 1 1 1 MHC_I C-terminus C2-set_2 PF08205.10 001171270.1_37923001_1 - 0.00016 21.5 0.1 0.0003 20.6 0.1 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001171270.1_37923001_1 - 0.0055 16.7 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001171270.1_37923001_1 - 0.082 13.1 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain Protocadherin PF08374.9 001171270.1_37923001_1 - 0.1 12.4 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 Protocadherin Peptidase_U32 PF01136.17 001171270.1_37923001_3 - 4.8 6.1 4.7 7 5.6 4.7 1.1 1 0 0 1 1 1 0 Peptidase family U32 MHC_I_3 PF16497.3 001123001.1_39523001_2 - 2.8e-91 304.3 2.5 3.6e-91 303.9 2.5 1.1 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001123001.1_39523001_2 - 3.5e-11 43.3 0.1 1.1e-10 41.7 0.0 2.0 2 1 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001123001.1_39523001_2 - 0.018 15.5 0.1 2.4 8.7 0.0 2.9 2 1 1 3 3 3 0 Immunoglobulin domain FixQ PF05545.9 001123001.1_39523001_2 - 0.068 13.0 1.4 0.22 11.4 1.4 1.9 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ ig PF00047.23 001123001.1_39523001_2 - 0.075 13.1 0.7 4 7.5 0.0 3.1 2 1 1 3 3 3 0 Immunoglobulin domain zf-CCCH_3 PF15663.3 001131382.1_43529001_3 - 8.8e-57 190.0 4.7 2e-56 188.8 4.7 1.6 1 0 0 1 1 1 1 Zinc-finger containing family Crystallin PF00525.16 001172935.1_09923001_1 - 2.3e-26 91.6 2.2 4.6e-26 90.7 2.2 1.5 1 0 0 1 1 1 1 Alpha crystallin A chain, N terminal HSP20 PF00011.19 001172935.1_09923001_1 - 4.6e-22 78.0 0.0 6.2e-22 77.5 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Phostensin PF13914.4 001128480.1_49824001_1 - 4.1e-33 114.8 3.3 1.2e-32 113.4 0.2 2.9 2 1 0 2 2 2 1 Phostensin PP1-binding and SH3-binding region Phostensin_N PF13916.4 001128480.1_49824001_1 - 4.1e-32 110.3 7.9 4.1e-32 110.3 7.9 4.3 2 2 2 4 4 4 2 PP1-regulatory protein, Phostensin N-terminal DUF2967 PF11179.6 001128480.1_49824001_1 - 0.071 12.4 8.6 0.19 11.0 8.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) Spt20 PF12090.6 001128480.1_49824001_1 - 0.085 12.3 5.6 0.15 11.5 5.6 1.4 1 0 0 1 1 1 0 Spt20 family SR-25 PF10500.7 001128480.1_49824001_2 - 2.8 7.3 9.8 6.2 6.2 9.8 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FA_desaturase PF00487.22 001135502.1_43527001_3 - 1.7e-32 113.2 29.1 1.7e-32 113.2 29.1 2.1 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.26 001135502.1_43527001_3 - 6.6e-20 70.9 0.0 1.2e-19 70.1 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain EF-hand_7 PF13499.4 001131585.1_43527001_1 - 0.037 14.4 0.1 0.056 13.8 0.1 1.3 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.4 001131585.1_43527001_1 - 0.097 12.5 0.1 0.29 11.0 0.1 1.8 1 0 0 1 1 1 0 EF-hand domain EF-hand_1 PF00036.30 001131585.1_43527001_1 - 0.32 10.5 1.3 1.9 8.1 0.6 2.3 2 0 0 2 2 2 0 EF hand DHO_dh PF01180.19 001132697.1_43529001_1 - 6.9e-35 120.5 0.0 3.3e-34 118.3 0.0 1.9 2 0 0 2 2 2 1 Dihydroorotate dehydrogenase Fer4_20 PF14691.4 001132697.1_43529001_1 - 7.7e-32 109.3 0.1 7.7e-32 109.3 0.1 2.4 3 0 0 3 3 3 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Fer4_21 PF14697.4 001132697.1_43529001_1 - 3.7e-23 81.3 13.5 3.7e-23 81.3 13.5 4.4 4 1 1 5 5 4 1 4Fe-4S dicluster domain Pyr_redox_2 PF07992.12 001132697.1_43529001_1 - 7.1e-14 51.6 0.0 1.1e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.4 001132697.1_43529001_1 - 3.5e-07 30.2 0.0 7.9e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Dus PF01207.15 001132697.1_43529001_1 - 1.4e-06 27.5 0.0 3.4e-06 26.2 0.1 1.5 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) Fer4_7 PF12838.5 001132697.1_43529001_1 - 5.4e-05 23.6 9.4 5.4e-05 23.6 9.4 4.0 3 2 0 3 3 2 1 4Fe-4S dicluster domain Pyr_redox_3 PF13738.4 001132697.1_43529001_1 - 5.7e-05 22.4 0.0 0.19 10.8 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.25 001132697.1_43529001_1 - 0.00029 21.2 0.1 0.85 10.1 0.1 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Fer4_10 PF13237.4 001132697.1_43529001_1 - 0.0013 18.7 11.7 0.0013 18.7 11.7 3.6 3 1 1 4 4 4 3 4Fe-4S dicluster domain Fer4_6 PF12837.5 001132697.1_43529001_1 - 0.0029 17.5 2.4 0.0029 17.5 2.4 5.1 5 0 0 5 5 4 2 4Fe-4S binding domain Fer4_2 PF12797.5 001132697.1_43529001_1 - 0.0058 16.5 2.4 0.0058 16.5 2.4 5.6 6 0 0 6 6 4 2 4Fe-4S binding domain Fer4_9 PF13187.4 001132697.1_43529001_1 - 0.0063 16.5 12.0 0.0063 16.5 12.0 3.7 3 1 1 4 4 3 1 4Fe-4S dicluster domain Fer4 PF00037.25 001132697.1_43529001_1 - 1.3 8.8 36.2 0.013 15.2 5.2 5.3 6 0 0 6 6 6 0 4Fe-4S binding domain Fer4_8 PF13183.4 001132697.1_43529001_1 - 6.5 7.1 27.0 8.2 6.8 1.0 4.0 3 1 0 3 3 3 0 4Fe-4S dicluster domain Sulfate_transp PF00916.18 001159756.1_39525001_1 - 4.6e-130 433.7 21.7 6.7e-130 433.1 21.7 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.19 001159756.1_39525001_1 - 1.1e-28 99.1 0.1 2.4e-28 98.0 0.1 1.6 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.4 001159756.1_39525001_1 - 0.041 14.1 0.0 0.088 13.0 0.0 1.5 1 0 0 1 1 1 0 STAS domain ThiF PF00899.19 001133483.1_43525001_2 - 3.7e-48 163.9 0.0 5.4e-48 163.4 0.0 1.2 1 0 0 1 1 1 1 ThiF family Lon_C PF05362.11 001168591.1_32924001_1 - 3.9e-82 274.6 0.0 5.8e-82 274.1 0.0 1.2 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.27 001168591.1_32924001_1 - 3.2e-10 40.4 0.0 6.2e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ChlI PF13541.4 001168591.1_32924001_1 - 8.9e-06 25.4 0.0 2.3e-05 24.1 0.0 1.7 1 1 0 1 1 1 1 Subunit ChlI of Mg-chelatase Pkinase PF00069.23 001133533.1_43529001_3 - 1.1e-62 211.6 0.0 1.5e-62 211.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001133533.1_43529001_3 - 6.3e-47 159.9 0.0 9e-47 159.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.6 001133533.1_43529001_3 - 2e-13 49.9 0.0 3.6e-13 49.1 0.0 1.4 1 0 0 1 1 1 1 Oxidative-stress-responsive kinase 1 C terminal Kinase-like PF14531.4 001133533.1_43529001_3 - 0.0022 17.2 0.0 0.0036 16.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kelch_1 PF01344.23 001134070.2_43526001_1 - 1.6e-87 286.8 19.4 6.5e-16 57.5 0.4 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.4 001134070.2_43526001_1 - 1.4e-50 167.9 6.8 2.7e-09 36.8 0.0 6.5 2 2 4 6 6 6 6 Kelch motif BACK PF07707.13 001134070.2_43526001_1 - 2.2e-38 130.4 0.1 4.8e-38 129.3 0.1 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_4 PF13418.4 001134070.2_43526001_1 - 1.3e-35 121.0 2.7 3.8e-06 26.6 0.0 6.4 4 1 2 6 6 6 6 Galactose oxidase, central domain BTB PF00651.29 001134070.2_43526001_1 - 1.5e-32 112.0 0.3 3e-32 111.0 0.3 1.5 1 0 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.4 001134070.2_43526001_1 - 2.7e-32 110.2 13.8 1.1e-05 25.5 0.0 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.13 001134070.2_43526001_1 - 3.7e-28 96.3 5.8 1.8e-06 27.6 0.2 6.7 6 0 0 6 6 6 6 Kelch motif Kelch_5 PF13854.4 001134070.2_43526001_1 - 0.001 18.9 6.0 3.2 7.7 0.1 4.9 5 0 0 5 5 5 2 Kelch motif XPA_C PF05181.10 001134070.2_43526001_1 - 0.12 12.3 0.9 8 6.4 0.0 3.3 4 0 0 4 4 4 0 XPA protein C-terminus Glu_cyclase_2 PF05096.10 001134070.2_43526001_1 - 0.19 11.0 0.0 29 3.8 0.0 2.6 1 1 1 3 3 3 0 Glutamine cyclotransferase PQQ_3 PF13570.4 001134070.2_43526001_1 - 1.3 9.5 9.7 3.3 8.2 0.3 4.0 4 0 0 4 4 4 0 PQQ-like domain 7tm_1 PF00001.19 001172949.1_09925001_1 - 6.7e-28 97.5 25.1 1.1e-27 96.9 25.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GnHR_trans PF12369.6 001172949.1_09925001_1 - 1.4e-25 89.7 0.5 2.6e-25 88.9 0.5 1.5 1 0 0 1 1 1 1 Gonadotropin hormone receptor transmembrane region LRR_8 PF13855.4 001172949.1_09925001_1 - 2.1e-20 72.1 16.0 5.4e-07 29.2 0.0 5.3 2 2 3 5 5 5 4 Leucine rich repeat LRR_5 PF13306.4 001172949.1_09925001_1 - 3.4e-13 49.5 0.3 8e-07 28.9 0.0 2.4 1 1 0 2 2 2 2 Leucine rich repeats (6 copies) LRRNT PF01462.16 001172949.1_09925001_1 - 8.3e-08 31.6 3.5 8.3e-08 31.6 3.5 2.1 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_4 PF12799.5 001172949.1_09925001_1 - 8.9e-06 25.8 22.4 0.43 10.9 4.0 4.7 3 1 0 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001172949.1_09925001_1 - 0.0018 17.7 2.3 0.04 13.3 0.7 2.5 2 0 0 2 2 2 1 Leucine-rich repeat Lectin_C PF00059.19 001172879.1_09922001_2 - 1.3e-08 35.4 1.7 1.9e-08 34.9 1.7 1.3 1 0 0 1 1 1 1 Lectin C-type domain Spin-Ssty PF02513.15 001132165.1_43527001_2 - 2.9e-10 39.6 0.1 6.2e-10 38.5 0.1 1.5 1 0 0 1 1 1 1 Spin/Ssty Family 7tm_1 PF00001.19 001172911.1_09926001_2 - 4.5e-49 167.0 15.8 6e-49 166.5 15.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001172911.1_09926001_2 - 1.2e-11 44.4 13.5 5.2e-11 42.3 13.5 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001172911.1_09926001_2 - 3.7e-09 36.6 10.9 1.6e-08 34.5 10.9 1.8 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001172911.1_09926001_2 - 0.033 13.4 8.9 0.016 14.4 6.8 1.6 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx IncA PF04156.12 001133631.1_43526001_3 - 0.0008 19.1 0.0 0.0013 18.4 0.0 1.2 1 0 0 1 1 1 1 IncA protein EphA2_TM PF14575.4 001133631.1_43526001_3 - 0.0051 17.5 0.0 0.0092 16.6 0.0 1.4 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain CENP-T_C PF15511.4 001135489.1_43525001_1 - 4.2e-07 29.9 0.0 6.9e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.15 001135489.1_43525001_1 - 0.0005 20.1 0.0 0.0008 19.4 0.0 1.3 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.4 001135489.1_43525001_1 - 0.00091 19.4 0.0 0.0016 18.6 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein Histone PF00125.22 001135489.1_43525001_1 - 0.0033 17.7 0.1 0.0052 17.0 0.1 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.21 001135489.1_43525001_1 - 0.0058 16.8 0.0 0.01 16.0 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.13 001135489.1_43525001_1 - 0.099 12.6 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit SH3BGR PF04908.13 001131128.2_43524001_1 - 3.8e-45 152.0 0.0 5.3e-45 151.5 0.0 1.2 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.22 001131128.2_43524001_1 - 0.0046 17.0 0.0 0.0088 16.1 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin ATP-gua_Ptrans PF00217.17 001163070.1_37923001_3 - 1.9e-92 309.2 0.0 2.3e-92 308.9 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.13 001163070.1_37923001_3 - 1.6e-32 111.6 0.0 2.6e-32 110.9 0.0 1.4 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain ATG13 PF10033.7 001131462.2_43529001_2 - 4.6e-13 49.2 0.0 4.6e-07 29.6 0.0 2.5 1 1 1 2 2 2 2 Autophagy-related protein 13 p450 PF00067.20 001173117.1_09925001_1 - 1.1e-128 429.8 2.3 1.2e-128 429.6 2.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 DSPc PF00782.18 001197094.1_21022001_1 - 1e-26 93.2 0.0 1.3e-26 92.9 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.25 001197094.1_21022001_1 - 0.0011 18.5 0.0 0.0013 18.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.10 001197094.1_21022001_1 - 0.012 15.8 0.0 0.024 14.8 0.0 1.5 1 0 0 1 1 1 0 Rit1 DUSP-like domain DSPn PF14671.4 001197094.1_21022001_1 - 0.085 13.2 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half PTPlike_phytase PF14566.4 001197094.1_21022001_1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate MHC_I_3 PF16497.3 001172849.1_09923001_1 - 1.3e-58 197.7 0.0 1.8e-58 197.2 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001172849.1_09923001_1 - 3.6e-11 43.2 0.0 6.2e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001172849.1_09923001_1 - 0.009 15.5 0.0 0.014 14.8 0.0 1.4 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 ig PF00047.23 001172849.1_09923001_1 - 0.053 13.6 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Ig_3 PF13927.4 001172849.1_09923001_1 - 0.099 13.1 0.1 0.4 11.2 0.1 1.9 1 1 1 2 2 2 0 Immunoglobulin domain DUF4381 PF14316.4 001172849.1_09923001_1 - 0.39 10.8 1.9 1.2 9.3 1.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Opiods_neuropep PF01160.16 001173417.1_09923001_1 - 1.1e-15 57.3 6.0 2.4e-15 56.2 6.0 1.6 1 0 0 1 1 1 1 Vertebrate endogenous opioids neuropeptide Op_neuropeptide PF08035.9 001173417.1_09923001_1 - 0.21 11.3 36.2 4.8 7.0 0.3 7.1 7 0 0 7 7 7 0 Opioids neuropeptide SRF-TF PF00319.16 001173417.1_09923001_1 - 0.72 9.2 2.5 2.2 7.7 0.1 2.7 3 0 0 3 3 3 0 SRF-type transcription factor (DNA-binding and dimerisation domain) Oxidored_molyb PF00174.17 173733.3_32925001_1 - 1.3e-63 213.5 0.0 2.1e-63 212.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.14 173733.3_32925001_1 - 4.7e-42 143.1 0.8 8.3e-42 142.3 0.8 1.4 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Cyt-b5 PF00173.26 173733.3_32925001_1 - 9.1e-13 48.0 0.0 1.4e-12 47.4 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Lys PF00062.18 001172889.1_09922001_1 - 6e-52 175.0 6.3 7.8e-52 174.6 6.3 1.1 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family Kelch_1 PF01344.23 029652.1_32927001_3 - 1.4e-50 168.5 11.1 8.3e-12 44.4 0.3 5.8 6 0 0 6 6 6 5 Kelch motif BACK PF07707.13 029652.1_32927001_3 - 9.3e-31 105.9 1.9 9.3e-31 105.9 1.9 1.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_6 PF13964.4 029652.1_32927001_3 - 7e-29 99.0 5.8 3.9e-06 26.8 0.0 6.0 2 1 4 6 6 6 5 Kelch motif Kelch_4 PF13418.4 029652.1_32927001_3 - 1.5e-26 92.0 0.3 6.3e-07 29.1 0.0 5.6 5 0 0 5 5 5 4 Galactose oxidase, central domain BTB PF00651.29 029652.1_32927001_3 - 6.6e-26 90.6 0.1 1e-25 89.9 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.4 029652.1_32927001_3 - 3.5e-25 87.6 2.4 2.8e-05 24.1 0.0 6.2 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.13 029652.1_32927001_3 - 4.8e-25 86.4 8.0 8.9e-05 22.2 0.0 6.4 5 1 0 5 5 5 5 Kelch motif Kelch_5 PF13854.4 029652.1_32927001_3 - 5.4e-12 45.3 5.9 4.2e-06 26.5 0.0 5.5 5 0 0 5 5 5 2 Kelch motif DUF3342 PF11822.6 029652.1_32927001_3 - 0.006 16.6 0.0 0.032 14.3 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3342) DUF1668 PF07893.11 029652.1_32927001_3 - 0.0092 15.2 0.5 0.032 13.4 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1668) Root_cap PF06830.9 029652.1_32927001_3 - 0.12 12.4 0.0 0.32 11.1 0.0 1.7 1 0 0 1 1 1 0 Root cap ubiquitin PF00240.21 001173065.1_09923001_2 - 1.1e-138 451.0 16.2 6.7e-34 115.3 0.3 4.0 4 0 0 4 4 4 4 Ubiquitin family Rad60-SLD PF11976.6 001173065.1_09923001_2 - 6.2e-67 221.3 17.0 5.4e-16 58.0 0.4 4.0 4 0 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.4 001173065.1_09923001_2 - 5.9e-26 90.6 7.0 9.7e-05 22.6 0.1 5.7 4 4 0 4 4 4 4 Ubiquitin-like domain Rad60-SLD_2 PF13881.4 001173065.1_09923001_2 - 8e-15 54.8 2.3 0.093 12.7 0.0 4.9 4 4 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 001173065.1_09923001_2 - 3.4e-12 46.7 0.4 0.63 10.5 0.0 4.2 1 1 1 4 4 4 4 DUF2407 ubiquitin-like domain Telomere_Sde2 PF13019.4 001173065.1_09923001_2 - 2e-08 34.1 0.1 3 7.5 0.0 4.1 1 1 3 4 4 4 4 Telomere stability and silencing DUF2870 PF11069.6 001173065.1_09923001_2 - 4.3e-07 30.1 0.0 12 6.1 0.0 4.7 4 0 0 4 4 4 0 Protein of unknown function (DUF2870) RBD PF02196.13 001173065.1_09923001_2 - 1e-05 25.4 0.0 25 4.9 0.0 4.5 4 0 0 4 4 4 0 Raf-like Ras-binding domain PI3K_rbd PF00794.16 001173065.1_09923001_2 - 1.6e-05 24.9 1.6 5.4 7.1 0.0 4.5 4 0 0 4 4 4 1 PI3-kinase family, ras-binding domain DUF969 PF06149.10 001173065.1_09923001_2 - 9.8e-05 21.7 0.0 17 4.6 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF969) DUF3861 PF12977.5 001173065.1_09923001_2 - 0.00029 20.8 1.3 46 4.1 0.0 4.2 4 0 0 4 4 4 0 Domain of Unknown Function with PDB structure (DUF3861) FERM_f0 PF16511.3 001173065.1_09923001_2 - 0.00041 20.5 13.4 34 4.7 0.3 7.3 4 4 0 4 4 4 0 N-terminal or F0 domain of Talin-head FERM FlgD_ig PF13860.4 001173065.1_09923001_2 - 0.00051 19.7 3.7 32 4.3 0.0 4.3 4 0 0 4 4 4 0 FlgD Ig-like domain TraK PF06586.9 001173065.1_09923001_2 - 0.0057 16.2 0.2 55 3.2 0.0 4.0 4 0 0 4 4 4 0 TraK protein ORF11CD3 PF10549.7 001173065.1_09923001_2 - 0.0078 16.2 0.0 97 3.1 0.0 4.5 4 0 0 4 4 4 0 ORF11CD3 domain GDYXXLXY PF14345.4 001173065.1_09923001_2 - 0.013 15.2 0.2 1.1e+02 2.4 0.0 4.1 4 0 0 4 4 4 0 GDYXXLXY protein CorA PF01544.16 001173065.1_09923001_2 - 0.015 14.5 0.3 73 2.4 0.0 3.8 4 0 0 4 4 4 0 CorA-like Mg2+ transporter protein fn3_2 PF16893.3 001173065.1_09923001_2 - 0.037 14.0 0.3 10 6.2 0.0 3.8 1 1 3 4 4 4 0 Fibronectin type III domain ProRS-C_2 PF09181.8 001173065.1_09923001_2 - 0.061 13.3 3.1 1.4e+02 2.6 0.0 4.0 4 0 0 4 4 4 0 Prolyl-tRNA synthetase, C-terminal Plexin_cytopl PF08337.10 001173065.1_09923001_2 - 0.31 9.5 8.5 17 3.8 0.1 4.6 2 1 0 4 4 4 0 Plexin cytoplasmic RasGAP domain PI3K_p85B PF02192.14 001173065.1_09923001_2 - 4.7 6.9 6.9 1.7e+02 1.9 0.1 4.0 4 0 0 4 4 4 0 PI3-kinase family, p85-binding domain p450 PF00067.20 001172940.1_09926001_3 - 1.2e-105 353.9 0.0 1.5e-105 353.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ITI_HC_C PF06668.10 010582.3_32927001_2 - 1.9e-68 229.7 0.0 3.7e-68 228.8 0.0 1.5 1 0 0 1 1 1 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus VIT PF08487.8 010582.3_32927001_2 - 8.8e-32 109.5 0.2 2e-31 108.4 0.2 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA PF00092.26 010582.3_32927001_2 - 2.2e-22 80.0 2.3 3.5e-22 79.4 2.3 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.4 010582.3_32927001_2 - 1.7e-18 66.8 0.0 2.9e-18 66.1 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.4 010582.3_32927001_2 - 7.3e-12 45.8 0.2 1.8e-11 44.5 0.2 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.12 010582.3_32927001_2 - 0.00026 20.3 0.0 0.00047 19.5 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein vWA-TerF-like PF10138.7 010582.3_32927001_2 - 0.00036 20.6 0.3 0.00087 19.3 0.3 1.6 1 0 0 1 1 1 1 vWA found in TerF C terminus SWIB PF02201.16 010582.3_32927001_2 - 0.039 13.7 0.0 0.092 12.5 0.0 1.5 1 0 0 1 1 1 0 SWIB/MDM2 domain DUF2201 PF09967.7 010582.3_32927001_2 - 0.098 12.7 0.4 0.39 10.7 0.0 2.1 2 0 0 2 2 2 0 VWA-like domain (DUF2201) SH3_8 PF13457.4 010582.3_32927001_2 - 0.099 13.1 0.0 0.44 11.1 0.0 2.1 2 0 0 2 2 2 0 SH3-like domain IL4 PF00727.16 001171106.1_37921001_3 - 2.8e-32 111.1 3.2 8.1e-31 106.4 2.8 2.0 1 1 1 2 2 2 2 Interleukin 4 Cadherin PF00028.15 001024129.2_39727001_1 - 6.3e-80 263.6 0.0 2.7e-18 66.1 0.0 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001024129.2_39727001_1 - 7.4e-38 128.1 0.1 1.2e-34 117.8 0.1 3.7 4 0 0 4 4 4 2 Cadherin-like Cadherin_C_2 PF16492.3 001024129.2_39727001_1 - 1.9e-28 98.9 0.7 4.4e-28 97.8 0.7 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001024129.2_39727001_1 - 3.4e-05 23.7 3.7 0.066 13.1 0.0 4.4 4 0 0 4 4 4 2 Cadherin-like p450 PF00067.20 001123000.1_39524001_1 - 3.5e-100 335.8 0.6 4.7e-100 335.4 0.6 1.0 1 0 0 1 1 1 1 Cytochrome P450 ACT_5 PF13710.4 001123000.1_39524001_1 - 0.048 13.4 1.0 7.3 6.4 0.2 3.0 3 0 0 3 3 3 0 ACT domain DUF2098 PF09871.7 001131745.1_43523001_1 - 0.53 10.5 11.3 1.1 9.5 11.3 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) FAM176 PF14851.4 001131745.1_43523001_1 - 0.9 9.1 2.6 1.4 8.5 2.6 1.3 1 0 0 1 1 1 0 FAM176 family EphA2_TM PF14575.4 001131745.1_43523001_1 - 1.7 9.4 4.3 5.5 7.7 4.3 1.9 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain HMG14_17 PF01101.16 001131745.1_43523001_3 - 3.2e-25 88.7 21.5 3.2e-25 88.7 21.5 2.8 3 0 0 3 3 3 1 HMG14 and HMG17 PARM PF17061.3 001131745.1_43523001_3 - 3 7.8 6.6 4 7.4 6.6 1.1 1 0 0 1 1 1 0 PARM p450 PF00067.20 001171113.1_37924001_2 - 4e-159 530.1 0.1 4.6e-159 529.9 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.23 001160284.1_37923001_2 - 7.3e-72 241.8 0.2 8.6e-72 241.5 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001160284.1_37923001_2 - 1.2e-19 70.5 0.0 1.7e-19 70.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 001160284.1_37923001_2 - 1e-07 32.0 0.1 5.9e-06 26.2 0.1 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.12 001160284.1_37923001_2 - 0.0044 16.3 0.1 0.0073 15.5 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 001160284.1_37923001_2 - 0.0092 15.2 0.1 0.048 12.8 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Choline_kinase PF01633.18 001160284.1_37923001_2 - 0.015 14.8 1.2 0.017 14.6 0.1 1.6 2 0 0 2 2 2 0 Choline/ethanolamine kinase ABC1 PF03109.14 001160284.1_37923001_2 - 0.073 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 ABC1 family FTA2 PF13095.4 001160284.1_37923001_2 - 0.11 12.0 0.3 1.3 8.4 0.0 2.5 2 1 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 zf-H2C2_2 PF13465.4 001131498.1_43527001_2 - 2.1e-147 473.4 126.0 2.2e-08 34.0 0.2 23.5 23 0 0 23 23 23 21 Zinc-finger double domain zf-C2H2 PF00096.24 001131498.1_43527001_2 - 1.3e-126 406.3 141.6 3.6e-07 30.1 0.9 23.5 23 0 0 23 23 23 22 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001131498.1_43527001_2 - 2e-67 217.8 136.5 0.0023 18.5 0.7 23.5 23 0 0 23 23 23 20 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001131498.1_43527001_2 - 1.9e-24 85.3 86.1 0.00058 19.8 1.2 14.4 7 5 9 16 16 16 12 Zinc ribbon domain zf-C2H2_6 PF13912.4 001131498.1_43527001_2 - 2.1e-21 75.3 113.7 0.051 13.4 0.4 21.7 22 0 0 22 22 21 14 C2H2-type zinc finger KRAB PF01352.25 001131498.1_43527001_2 - 7.2e-16 57.5 0.2 1.4e-15 56.5 0.2 1.5 1 0 0 1 1 1 1 KRAB box DZR PF12773.5 001131498.1_43527001_2 - 1.9e-14 53.2 75.9 39 4.2 11.4 11.4 2 2 1 3 3 2 0 Double zinc ribbon DUF3268 PF11672.6 001131498.1_43527001_2 - 1.3e-09 38.3 70.4 0.21 11.8 0.9 12.2 7 2 8 15 15 15 11 zinc-finger-containing domain C1_4 PF07975.10 001131498.1_43527001_2 - 5.5e-09 36.0 89.6 0.18 12.0 7.5 13.7 6 4 8 15 15 15 7 TFIIH C1-like domain zinc_ribbon_15 PF17032.3 001131498.1_43527001_2 - 3.1e-08 34.1 85.3 0.47 11.1 1.4 11.7 1 1 14 15 15 15 10 zinc-ribbon family ADK_lid PF05191.12 001131498.1_43527001_2 - 3.6e-08 33.2 54.8 0.082 12.8 3.9 12.7 6 4 5 12 12 12 3 Adenylate kinase, active site lid XPA_N PF01286.16 001131498.1_43527001_2 - 5.1e-07 29.5 74.7 10 6.1 0.0 19.9 21 0 0 21 21 21 0 XPA protein N-terminal zf-C2H2_jaz PF12171.6 001131498.1_43527001_2 - 3.7e-06 27.0 101.3 0.035 14.3 0.1 19.3 22 0 0 22 22 22 7 Zinc-finger double-stranded RNA-binding zf-trcl PF13451.4 001131498.1_43527001_2 - 6.4e-05 22.6 82.5 15 5.5 1.0 20.0 19 2 1 20 20 20 0 Probable zinc-ribbon domain zf-LYAR PF08790.9 001131498.1_43527001_2 - 0.00051 19.8 90.1 0.9 9.4 0.6 19.6 20 0 0 20 20 20 5 LYAR-type C2HC zinc finger Zn_ribbon_recom PF13408.4 001131498.1_43527001_2 - 0.02 15.3 91.5 14 6.1 0.6 15.4 5 3 10 15 15 15 0 Recombinase zinc beta ribbon domain zinc_ribbon_9 PF14369.4 001131498.1_43527001_2 - 0.029 14.5 55.2 24 5.2 0.0 17.4 20 1 0 20 20 20 0 zinc-ribbon CpXC PF14353.4 001131498.1_43527001_2 - 0.056 13.3 73.5 4.7 7.1 0.1 16.9 2 2 11 17 17 17 0 CpXC protein MBD PF01429.17 001131498.1_43527001_2 - 0.21 11.2 3.5 4.2 7.0 0.3 4.5 3 1 0 3 3 3 0 Methyl-CpG binding domain zf-met PF12874.5 001131498.1_43527001_2 - 5 7.5 125.2 0.22 11.8 0.4 19.8 20 1 1 21 21 21 0 Zinc-finger of C2H2 type BDHCT_assoc PF16204.3 001131498.1_43527001_2 - 7.7 6.0 13.7 1.5 8.3 0.3 4.5 3 1 1 5 5 5 0 BDHCT-box associated domain on Bloom syndrome protein zf-H2C2_2 PF13465.4 001131421.1_43528001_1 - 3.5e-87 283.1 104.5 2.1e-08 34.1 2.1 13.8 13 0 0 13 13 13 12 Zinc-finger double domain zf-C2H2 PF00096.24 001131421.1_43528001_1 - 5.7e-45 149.2 96.2 5.4e-05 23.3 1.1 14.0 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_6 PF13912.4 001131421.1_43528001_1 - 1.1e-25 88.8 93.7 0.00088 19.0 0.5 13.1 13 0 0 13 13 13 11 C2H2-type zinc finger KRAB PF01352.25 001131421.1_43528001_1 - 3.9e-25 87.1 0.9 6.5e-25 86.4 0.9 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 001131421.1_43528001_1 - 3.7e-24 83.2 93.4 0.0032 18.0 0.8 13.9 13 0 0 13 13 13 11 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001131421.1_43528001_1 - 3e-12 46.3 71.3 0.0018 18.2 1.0 8.4 7 2 0 7 7 7 6 Zinc ribbon domain zf-C2H2_jaz PF12171.6 001131421.1_43528001_1 - 7.1e-06 26.1 69.0 0.31 11.3 1.0 13.3 13 0 0 13 13 13 5 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 001131421.1_43528001_1 - 0.16 12.6 52.8 0.51 11.0 1.2 7.0 2 1 6 8 8 8 0 zinc-ribbon family XPA_N PF01286.16 001131421.1_43528001_1 - 1.3 9.0 58.9 7.4 6.6 0.0 12.2 12 0 0 12 12 12 0 XPA protein N-terminal zf-trcl PF13451.4 001131421.1_43528001_1 - 2.9 7.7 63.1 4.2 7.2 0.1 11.9 11 2 0 11 11 11 0 Probable zinc-ribbon domain Annexin PF00191.18 001167639.1_49822001_1 - 2e-103 338.3 9.5 1.2e-25 89.2 0.1 4.0 4 0 0 4 4 4 4 Annexin Myb_DNA-bind_7 PF15963.3 001167639.1_49822001_1 - 0.0098 15.6 1.0 5.4 6.8 0.1 3.8 3 1 1 4 4 4 1 Myb DNA-binding like 7tm_2 PF00002.22 001172924.1_09923001_2 - 2.1e-86 289.1 22.4 2.8e-86 288.7 22.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 001172924.1_09923001_2 - 8.6e-19 67.5 6.7 1.6e-18 66.6 6.7 1.5 1 0 0 1 1 1 1 Hormone receptor domain zf-C4 PF00105.16 001135615.1_39723001_1 - 2.3e-28 98.3 11.1 3.8e-28 97.6 11.1 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001135615.1_39723001_1 - 1.1e-18 67.4 0.1 2.4e-18 66.3 0.1 1.5 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor PAPA-1 PF04795.10 001135615.1_39723001_1 - 0.037 14.7 1.0 0.068 13.8 1.0 1.4 1 0 0 1 1 1 0 PAPA-1-like conserved region YdjO PF14169.4 001135615.1_39723001_1 - 0.74 9.5 3.4 0.42 10.2 0.3 2.1 1 1 1 2 2 2 0 Cold-inducible protein YdjO SR-25 PF10500.7 001133548.1_43522001_1 - 0.018 14.5 25.2 0.023 14.2 25.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4604 PF15377.4 001133548.1_43522001_1 - 0.067 13.5 16.9 0.084 13.2 16.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) RNA_polI_A34 PF08208.9 001133548.1_43522001_1 - 0.088 12.8 23.7 0.11 12.4 23.7 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF4604 PF15377.4 001133548.1_43522001_2 - 0.0023 18.3 11.6 0.0028 18.0 11.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) SR-25 PF10500.7 001133548.1_43522001_2 - 0.075 12.5 25.5 0.099 12.1 25.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ribosomal_S3_C PF00189.18 001133548.1_43522001_3 - 2.9e-23 82.1 0.9 1.2e-22 80.1 0.2 2.3 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.15 001133548.1_43522001_3 - 2.2e-11 43.3 0.1 4.6e-11 42.3 0.1 1.6 1 0 0 1 1 1 1 KH domain Coilin_N PF15862.3 001133548.1_43522001_3 - 0.0085 15.8 17.1 1.2 8.7 0.0 2.2 2 0 0 2 2 2 1 Coilin N-terminus DUF4604 PF15377.4 001133548.1_43522001_3 - 0.022 15.1 15.1 0.031 14.6 15.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) SR-25 PF10500.7 001133548.1_43522001_3 - 3 7.3 32.5 4.2 6.8 32.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein 7tm_1 PF00001.19 001172963.1_09923001_1 - 1.7e-68 230.6 13.2 2.1e-68 230.3 13.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) WD40 PF00400.30 001133897.1_43529001_1 - 8.6e-18 64.2 18.5 0.00047 20.8 0.1 10.5 10 0 0 10 10 10 4 WD domain, G-beta repeat Choline_sulf_C PF12411.6 001133897.1_43529001_1 - 0.095 12.4 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Choline sulfatase enzyme C terminal Nsp3_PL2pro PF12124.6 001133897.1_43529001_1 - 0.11 12.1 0.0 0.32 10.7 0.0 1.7 2 0 0 2 2 2 0 Coronavirus polyprotein cleavage domain COX6A PF02046.13 001170883.2_37922001_2 - 1.9e-17 63.6 0.0 3.4e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa ADH_N PF08240.10 001170871.1_37924001_2 - 2.2e-23 82.1 0.2 3.9e-23 81.3 0.2 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.24 001170871.1_37924001_2 - 2.1e-20 72.8 0.4 4e-20 71.9 0.4 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.4 001170871.1_37924001_2 - 0.0023 18.8 0.0 0.0051 17.7 0.0 1.5 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.3 001170871.1_37924001_2 - 0.012 15.0 0.3 0.88 8.9 0.1 2.1 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus UDPG_MGDP_dh_N PF03721.12 001170871.1_37924001_2 - 0.049 13.1 0.1 0.085 12.3 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.19 001170871.1_37924001_2 - 0.13 11.4 3.0 0.11 11.7 1.1 1.7 1 1 1 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain RRM_1 PF00076.20 001135206.1_39725001_2 - 4.6e-23 80.7 0.2 9.5e-23 79.7 0.1 1.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM1CTR PF08081.9 001135206.1_39725001_2 - 1.6e-22 79.1 14.1 1.6e-22 79.1 14.1 8.6 5 2 3 8 8 8 1 RBM1CTR (NUC064) family RRM_7 PF16367.3 001135206.1_39725001_2 - 0.0042 17.1 0.0 0.011 15.7 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.4 001135206.1_39725001_2 - 0.031 13.7 0.0 0.059 12.9 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001135206.1_39725001_2 - 0.12 12.1 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif Ig_3 PF13927.4 001171150.1_37926001_1 - 1.5e-31 108.7 18.6 1.3e-10 41.6 0.0 10.0 8 4 0 8 8 8 6 Immunoglobulin domain Ig_2 PF13895.4 001171150.1_37926001_1 - 6.1e-31 106.5 0.9 1e-06 28.8 0.0 9.5 8 3 0 8 8 8 6 Immunoglobulin domain I-set PF07679.14 001171150.1_37926001_1 - 3.3e-26 91.0 7.5 5.2e-05 23.1 0.0 9.6 10 1 0 10 10 10 6 Immunoglobulin I-set domain ig PF00047.23 001171150.1_37926001_1 - 2.6e-24 85.1 0.8 3.8e-05 23.6 0.0 10.6 11 1 0 11 11 11 4 Immunoglobulin domain ICAM_N PF03921.12 001171150.1_37926001_1 - 8e-16 57.4 0.0 4.2e-13 48.7 0.0 2.7 2 0 0 2 2 2 2 Intercellular adhesion molecule (ICAM), N-terminal domain Izumo-Ig PF16706.3 001171150.1_37926001_1 - 0.00017 21.4 0.0 19 5.3 0.0 4.1 4 0 0 4 4 4 2 Izumo-like Immunoglobulin domain V-set PF07686.15 001171150.1_37926001_1 - 0.0011 18.9 9.1 3.4 7.7 0.0 8.2 10 1 1 11 11 11 1 Immunoglobulin V-set domain C2-set_2 PF08205.10 001171150.1_37926001_1 - 0.0044 16.9 15.7 0.12 12.3 0.0 6.7 7 0 0 7 7 7 1 CD80-like C2-set immunoglobulin domain MHC_I_3 PF16497.3 001172852.1_09922001_1 - 9.2e-60 201.4 0.1 1.3e-59 200.9 0.1 1.2 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001172852.1_09922001_1 - 4.4e-11 43.0 0.0 8.4e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001172852.1_09922001_1 - 0.013 14.9 0.0 0.022 14.2 0.0 1.4 1 1 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 ig PF00047.23 001172852.1_09922001_1 - 0.022 14.8 0.0 0.059 13.4 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain Ig_2 PF13895.4 001172852.1_09922001_1 - 0.094 12.9 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain DUF4381 PF14316.4 001172852.1_09922001_1 - 0.47 10.6 2.0 1 9.5 2.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) WD40 PF00400.30 001171076.1_37924001_1 - 1.4e-07 32.0 4.8 1.9 9.3 0.1 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001171076.1_37924001_1 - 0.0031 17.7 0.0 14 5.9 0.0 4.3 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Glyco_hydro_1 PF00232.16 053841.1_45729001_2 - 0 1792.5 5.2 5.1e-180 598.6 0.2 4.1 4 0 0 4 4 4 4 Glycosyl hydrolase family 1 SMC_Nse1 PF07574.11 001132144.1_43523001_1 - 6.1e-22 78.4 1.6 6.1e-22 78.4 1.6 3.1 2 1 0 2 2 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.9 001132144.1_43523001_1 - 9e-11 41.8 9.4 2.5e-10 40.4 9.4 1.8 1 0 0 1 1 1 1 RING-like domain Zip PF02535.20 001132144.1_43523001_1 - 0.0098 15.0 5.0 0.013 14.6 5.0 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter zf-RING_2 PF13639.4 001132144.1_43523001_1 - 0.012 15.8 10.0 0.026 14.6 10.0 1.6 1 0 0 1 1 1 0 Ring finger domain DDHD PF02862.15 001132144.1_43523001_1 - 0.022 14.8 7.8 0.019 15.0 6.5 1.6 2 0 0 2 2 2 0 DDHD domain SpoIIP PF07454.9 001132144.1_43523001_1 - 0.031 13.6 19.6 0.47 9.7 19.0 2.3 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) zf-C3HC4 PF00097.23 001132144.1_43523001_1 - 0.032 14.0 10.9 0.076 12.8 10.9 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RNA_pol_Rpc4 PF05132.12 001132144.1_43523001_1 - 0.081 13.2 21.7 0.21 11.9 21.7 1.7 1 0 0 1 1 1 0 RNA polymerase III RPC4 Zn_ribbon_17 PF17120.3 001132144.1_43523001_1 - 0.67 9.5 6.3 1.2 8.7 6.3 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.4 001132144.1_43523001_1 - 1 9.1 10.3 2.1 8.2 10.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF4834 PF16118.3 001132144.1_43523001_1 - 1.9 9.4 14.1 4.7 8.1 14.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF913 PF06025.10 001132144.1_43523001_1 - 2.3 6.9 9.7 3.9 6.2 9.7 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DDHD PF02862.15 001132144.1_43523001_2 - 0.0052 16.8 5.2 0.0058 16.7 5.2 1.1 1 0 0 1 1 1 1 DDHD domain RNA_pol_Rpc4 PF05132.12 001132144.1_43523001_2 - 0.027 14.8 19.8 0.044 14.1 19.8 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 EOS1 PF12326.6 001132144.1_43523001_2 - 0.077 12.8 5.4 0.1 12.4 5.4 1.3 1 0 0 1 1 1 0 N-glycosylation protein CLN3 PF02487.15 001132144.1_43523001_2 - 0.23 10.3 8.7 0.28 10.0 8.7 1.1 1 0 0 1 1 1 0 CLN3 protein Neur_chan_memb PF02932.14 001132144.1_43523001_2 - 0.48 10.3 6.8 0.54 10.1 6.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SpoIIP PF07454.9 001132144.1_43523001_2 - 0.61 9.4 20.7 0.75 9.1 20.7 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF3807 PF12720.5 001132144.1_43523001_2 - 0.96 9.6 27.8 1.8 8.7 27.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Connexin PF00029.17 001132144.1_43523001_2 - 5.2 6.6 19.4 8.5 5.9 19.4 1.3 1 0 0 1 1 1 0 Connexin AAA_11 PF13086.4 001132144.1_43523001_2 - 6.2 6.3 19.3 7.9 6.0 19.3 1.1 1 0 0 1 1 1 0 AAA domain RNA_pol_Rpc4 PF05132.12 001132144.1_43523001_3 - 4.7e-05 23.7 9.1 6e-05 23.4 9.1 1.2 1 0 0 1 1 1 1 RNA polymerase III RPC4 Scs3p PF10261.7 001132144.1_43523001_3 - 0.038 13.4 1.4 0.052 12.9 1.4 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM DDHD PF02862.15 001132144.1_43523001_3 - 0.078 13.0 12.1 0.097 12.7 12.1 1.1 1 0 0 1 1 1 0 DDHD domain PA26 PF04636.11 001132144.1_43523001_3 - 0.26 10.0 7.5 0.32 9.7 7.5 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Zip PF02535.20 001132144.1_43523001_3 - 0.32 10.0 10.2 0.4 9.7 10.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF1510 PF07423.9 001132144.1_43523001_3 - 0.52 9.6 24.1 0.68 9.2 24.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CLN3 PF02487.15 001132144.1_43523001_3 - 0.94 8.3 9.5 1.2 8.0 9.5 1.1 1 0 0 1 1 1 0 CLN3 protein DUF2052 PF09747.7 001132144.1_43523001_3 - 1.2 9.1 14.4 1.6 8.7 14.4 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) FPN1 PF06963.10 001132144.1_43523001_3 - 2.3 6.5 3.3 3.6 5.9 3.3 1.3 1 0 0 1 1 1 0 Ferroportin1 (FPN1) Serinc PF03348.13 001132144.1_43523001_3 - 2.5 6.8 6.9 3.2 6.5 6.9 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) GNAT_acetyltr_2 PF13718.4 001132144.1_43523001_3 - 4.6 6.5 10.8 6.6 5.9 10.8 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 CBP_BcsG PF11658.6 001132144.1_43523001_3 - 9 4.4 7.5 11 4.1 7.5 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG AAR2 PF05282.9 001134133.1_43525001_1 - 1.4e-105 353.4 0.0 1.8e-105 353.1 0.0 1.1 1 0 0 1 1 1 1 AAR2 protein WD40 PF00400.30 001171075.1_37924001_3 - 1.9e-08 34.7 4.8 4.5 8.2 0.1 6.6 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001171075.1_37924001_3 - 2.9e-05 24.2 0.1 0.44 10.7 0.0 4.1 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain zf-H2C2_2 PF13465.4 001132654.1_43524001_1 - 4.6e-60 197.4 74.6 3.3e-08 33.5 0.5 10.5 11 0 0 11 11 11 9 Zinc-finger double domain zf-C2H2 PF00096.24 001132654.1_43524001_1 - 3.9e-50 165.5 69.3 5.5e-06 26.4 1.1 10.2 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001132654.1_43524001_1 - 9.3e-27 91.3 63.8 0.0056 17.3 0.3 10.4 10 0 0 10 10 10 9 C2H2-type zinc finger C1_4 PF07975.10 001132654.1_43524001_1 - 3.4e-08 33.5 33.4 0.46 10.6 0.4 8.4 1 1 6 8 8 8 6 TFIIH C1-like domain Zn-ribbon_8 PF09723.8 001132654.1_43524001_1 - 4.6e-08 32.9 52.1 0.0044 17.0 2.8 7.5 5 4 5 10 10 9 6 Zinc ribbon domain zf-C2H2_6 PF13912.4 001132654.1_43524001_1 - 1.4e-07 31.1 41.7 1.4 8.8 0.2 9.6 9 0 0 9 9 9 5 C2H2-type zinc finger XPA_N PF01286.16 001132654.1_43524001_1 - 2e-07 30.8 41.2 2.4 8.2 0.4 9.9 10 0 0 10 10 10 4 XPA protein N-terminal CpXC PF14353.4 001132654.1_43524001_1 - 5.1e-06 26.4 27.7 2.2 8.2 0.1 9.1 4 2 3 9 9 9 2 CpXC protein zf-C2HC_2 PF13913.4 001132654.1_43524001_1 - 5.2e-05 22.9 24.5 1.2 9.0 0.0 7.9 7 0 0 7 7 7 3 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.3 001132654.1_43524001_1 - 0.012 15.2 47.6 0.15 11.7 0.1 9.6 9 0 0 9 9 9 0 zinc-finger C2H2-type Pectate_lyase22 PF14583.4 001132654.1_43524001_1 - 0.018 13.6 0.0 0.046 12.3 0.0 1.5 2 0 0 2 2 2 0 Oligogalacturonate lyase zf-C2H2_jaz PF12171.6 001132654.1_43524001_1 - 0.043 14.0 25.1 6.6 7.0 0.0 8.2 9 0 0 9 9 8 0 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.6 001132654.1_43524001_1 - 0.059 13.6 29.5 1 9.6 1.1 5.2 2 1 6 8 8 8 0 zinc-finger-containing domain zinc_ribbon_15 PF17032.3 001132654.1_43524001_1 - 0.11 13.1 44.2 0.47 11.1 3.9 6.3 2 2 4 7 7 7 0 zinc-ribbon family HypA PF01155.17 001132654.1_43524001_1 - 0.29 11.0 34.6 2.7 7.9 0.2 5.8 1 1 4 5 5 5 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-trcl PF13451.4 001132654.1_43524001_1 - 3.3 7.5 29.8 12 5.7 0.1 8.6 9 0 0 9 9 9 0 Probable zinc-ribbon domain Neocarzinostat PF00960.16 001132654.1_43524001_1 - 9.6 6.1 6.3 27 4.7 0.0 4.1 3 1 2 5 5 5 0 Neocarzinostatin family DNA_RNApol_7kD PF03604.11 001132654.1_43524001_1 - 9.9 5.8 35.2 3.1 7.4 0.3 9.1 9 0 0 9 9 9 0 DNA directed RNA polymerase, 7 kDa subunit KRAB PF01352.25 001132654.1_43524001_2 - 0.00022 20.7 0.0 0.00077 19.0 0.0 1.9 1 0 0 1 1 1 1 KRAB box 7tm_1 PF00001.19 001171125.1_37924001_1 - 6.2e-49 166.5 17.2 9.8e-49 165.8 17.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171125.1_37924001_1 - 3e-05 23.4 17.5 4.2e-05 22.9 17.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001171125.1_37924001_1 - 0.0015 17.8 10.6 0.002 17.4 10.2 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srab PF10292.7 001171125.1_37924001_1 - 0.77 8.5 12.8 0.66 8.7 4.0 2.3 1 1 1 2 2 2 0 Serpentine type 7TM GPCR receptor class ab chemoreceptor G-patch PF01585.21 001161734.1_39524001_1 - 5.6e-12 45.3 0.1 1.1e-11 44.3 0.1 1.5 1 0 0 1 1 1 1 G-patch domain zf-CCCH PF00642.22 001161734.1_39524001_1 - 0.00015 21.4 3.6 0.00028 20.6 3.6 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Agenet PF05641.10 001161734.1_39524001_1 - 0.0082 16.5 0.0 0.027 14.8 0.0 1.8 1 0 0 1 1 1 1 Agenet domain Laminin_I PF06008.12 001161734.1_39524001_1 - 0.017 14.7 5.2 0.032 13.8 5.2 1.4 1 0 0 1 1 1 0 Laminin Domain I ABC_tran_CTD PF16326.3 001161734.1_39524001_1 - 0.023 14.8 2.1 0.023 14.8 2.1 2.3 2 0 0 2 2 2 0 ABC transporter C-terminal domain zf-CCCH_2 PF14608.4 001161734.1_39524001_1 - 0.68 10.4 4.7 1.2 9.5 4.7 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Lipocalin PF00061.21 001171048.1_37925001_1 - 7.9e-06 26.0 0.0 1.1e-05 25.5 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin PF00061.21 001171048.1_37925001_2 - 8.6e-07 29.1 0.0 1.2e-06 28.6 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family p450 PF00067.20 001171048.1_37925001_3 - 3.9e-146 487.3 1.5 4.5e-146 487.1 1.5 1.0 1 0 0 1 1 1 1 Cytochrome P450 Wap1 PF16997.3 001171048.1_37925001_3 - 0.0089 15.1 0.0 0.013 14.5 0.0 1.1 1 0 0 1 1 1 1 Wap1 domain eIF-3c_N PF05470.10 001132184.1_43526001_2 - 7.5e-273 906.2 35.1 4.7e-271 900.2 35.1 2.1 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.25 001132184.1_43526001_2 - 4.7e-17 62.3 0.1 1.5e-16 60.6 0.1 2.0 1 0 0 1 1 1 1 PCI domain LAM_C PF12544.6 001132184.1_43526001_2 - 2.8 8.0 8.9 0.2 11.7 2.7 2.3 1 1 1 2 2 2 0 Lysine-2,3-aminomutase WD40 PF00400.30 001009006.2_39723001_1 - 1.2e-11 44.8 5.6 0.0015 19.2 0.1 5.6 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001009006.2_39723001_1 - 2.9e-07 30.6 0.0 0.21 11.8 0.0 4.1 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain BRK PF07533.14 001009006.2_39723001_1 - 0.015 14.8 0.2 0.073 12.6 0.2 2.1 2 0 0 2 2 2 0 BRK domain Cyt-b5 PF00173.26 001171264.1_37922001_1 - 3.1e-22 78.4 0.1 4.5e-22 77.8 0.1 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain HLH PF00010.24 001129741.1_39523001_1 - 4.8e-12 45.5 1.1 1.2e-11 44.2 1.1 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.11 001129741.1_39523001_1 - 5.4e-12 45.6 1.0 1.3e-11 44.3 1.0 1.7 1 0 0 1 1 1 1 Hairy Orange PDZ PF00595.22 139084.2_45729001_2 - 5.2e-65 215.7 6.8 5.7e-16 58.5 0.0 6.5 6 0 0 6 6 6 6 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 139084.2_45729001_2 - 4.4e-27 94.1 0.2 6.3e-05 23.1 0.0 6.5 6 0 0 6 6 6 5 PDZ domain WW PF00397.24 139084.2_45729001_2 - 1.6e-16 59.8 7.1 5.8e-09 35.6 0.5 2.5 2 0 0 2 2 2 2 WW domain Guanylate_kin PF00625.19 139084.2_45729001_2 - 1.4e-11 44.3 0.0 2.7e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 Guanylate kinase MAGI_u1 PF16663.3 139084.2_45729001_2 - 1.4e-05 24.9 6.8 4.1e-05 23.3 6.8 1.8 1 0 0 1 1 1 1 Unstructured region on MAGI Tricorn_PDZ PF14685.4 139084.2_45729001_2 - 2e-05 24.4 5.1 0.68 9.9 0.1 5.3 6 0 0 6 6 6 2 Tricorn protease PDZ domain OB_NTP_bind PF07717.14 001132717.1_43528001_3 - 2e-18 66.4 0.0 4.8e-18 65.2 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.21 001132717.1_43528001_3 - 7.8e-15 55.0 0.0 7.8e-15 55.0 0.0 1.9 2 0 0 2 2 1 1 Helicase associated domain (HA2) Helicase_C PF00271.29 001132717.1_43528001_3 - 1.7e-10 41.1 0.0 7.2e-10 39.1 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.27 001132717.1_43528001_3 - 7.9e-09 35.4 0.2 1.6e-08 34.4 0.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.18 001132717.1_43528001_3 - 4.2e-05 22.6 0.0 7.8e-05 21.7 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.4 001132717.1_43528001_3 - 6.2e-05 23.2 0.0 0.00015 21.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.4 001132717.1_43528001_3 - 0.00011 21.8 0.4 0.00031 20.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.7 001132717.1_43528001_3 - 0.00013 21.2 0.0 0.00023 20.4 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) DUF4685 PF15737.3 001132717.1_43528001_3 - 0.0019 18.5 1.2 0.49 10.7 1.5 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4685) AAA_19 PF13245.4 001132717.1_43528001_3 - 0.0034 17.6 0.0 0.0067 16.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.12 001132717.1_43528001_3 - 0.028 14.2 0.0 0.052 13.4 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain Helicase_RecD PF05127.12 001132717.1_43528001_3 - 0.086 12.6 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 Helicase PhoH PF02562.14 001132717.1_43528001_3 - 0.14 11.5 0.1 0.39 10.0 0.1 1.6 2 0 0 2 2 2 0 PhoH-like protein 7tm_1 PF00001.19 001159757.1_39524001_3 - 6.6e-67 225.4 1.5 1.1e-66 224.7 1.5 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001159757.1_39524001_3 - 5e-10 39.0 0.0 3.4e-09 36.3 0.0 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001159757.1_39524001_3 - 2.7e-06 27.2 1.1 4.4e-06 26.5 1.1 1.3 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001159757.1_39524001_3 - 0.006 15.8 0.9 0.0086 15.3 0.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.7 001159757.1_39524001_3 - 0.04 13.1 0.9 0.068 12.4 0.9 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv Ski_Sno PF02437.15 172446.3_32928001_2 - 1.8e-38 130.5 0.1 3.3e-38 129.7 0.1 1.4 1 0 0 1 1 1 1 SKI/SNO/DAC family c-SKI_SMAD_bind PF08782.8 172446.3_32928001_2 - 7e-31 106.2 1.1 7e-31 106.2 1.1 1.7 2 0 0 2 2 2 1 c-SKI Smad4 binding domain Rhodanese_C PF12368.6 001131769.1_43528001_3 - 8.1e-17 61.2 8.8 8.1e-17 61.2 8.8 2.2 2 0 0 2 2 2 1 Rhodanase C-terminal Rhodanese PF00581.18 001131769.1_43528001_3 - 9.3e-06 26.0 0.0 1.7e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain MHC_II_beta PF00969.17 001130471.1_39723001_2 - 1.9e-34 117.5 0.1 2.9e-34 116.9 0.1 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001130471.1_39723001_2 - 1.9e-23 82.6 0.0 3.5e-23 81.7 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain ig PF00047.23 001130471.1_39723001_2 - 0.032 14.3 0.0 0.058 13.4 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain MHC_I PF00129.16 001130471.1_39723001_2 - 0.045 13.2 0.0 0.067 12.6 0.0 1.2 1 0 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 C2-set_2 PF08205.10 001130471.1_39723001_2 - 0.15 12.0 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Hormone_2 PF00123.18 001126368.1_39522001_1 - 1.3e-29 101.7 1.8 4.7e-15 55.1 0.1 2.3 2 0 0 2 2 2 2 Peptide hormone COG5 PF10392.7 001126368.1_39522001_1 - 0.077 13.0 0.1 0.1 12.6 0.1 1.2 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Ank_2 PF12796.5 001163067.1_37924001_2 - 4.7e-32 110.3 0.5 5.1e-14 52.5 0.6 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001163067.1_37924001_2 - 3.6e-30 103.8 0.9 5.7e-10 39.4 0.2 4.5 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 001163067.1_37924001_2 - 2.8e-29 97.8 1.7 0.0003 20.9 0.0 7.2 7 0 0 7 7 7 6 Ankyrin repeat Ank PF00023.28 001163067.1_37924001_2 - 2.7e-26 90.7 3.3 6.1e-06 26.3 0.0 6.5 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.4 001163067.1_37924001_2 - 5.2e-18 64.7 3.7 2.1e-07 31.0 0.0 4.9 1 1 3 5 5 5 4 Ankyrin repeats (many copies) SOCS_box PF07525.14 001163067.1_37924001_2 - 3.1e-09 36.9 9.3 6.5e-09 35.9 9.3 1.6 1 0 0 1 1 1 1 SOCS box 7tm_1 PF00001.19 001171153.1_37923001_1 - 4.5e-77 258.8 8.7 6.4e-77 258.3 8.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001171153.1_37923001_1 - 1.4e-10 40.9 2.7 3e-10 39.8 2.7 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001171153.1_37923001_1 - 4.3e-06 26.5 9.7 0.00054 19.6 9.8 2.5 2 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001171153.1_37923001_1 - 0.0049 16.1 11.0 0.0049 16.1 11.0 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Abhydrolase_9_N PF15420.4 001171153.1_37923001_1 - 0.77 9.6 5.0 4.2 7.2 0.8 2.3 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus p450 PF00067.20 001171120.1_37924001_1 - 1.2e-159 531.9 0.4 1.5e-159 531.6 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3916 PF13079.4 001171120.1_37924001_1 - 0.03 14.1 0.1 0.072 12.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3916) Lectin_C PF00059.19 001173014.1_09924001_1 - 2.3e-19 70.0 0.0 3.4e-19 69.5 0.0 1.3 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 001173014.1_09924001_1 - 3.8e-10 39.2 33.3 2.5e-05 23.8 14.5 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) PAP2 PF01569.19 001173003.1_09922001_1 - 1.3e-27 96.1 0.9 2.5e-27 95.2 0.9 1.4 1 0 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.4 001173003.1_09922001_1 - 0.003 17.9 2.7 0.0091 16.4 2.7 1.8 1 0 0 1 1 1 1 PAP2 superfamily C-terminal Cadherin PF00028.15 001013014.2_39726001_3 - 2.9e-80 264.7 0.0 3.3e-17 62.6 0.0 6.2 6 0 0 6 6 6 5 Cadherin domain Cadherin_2 PF08266.10 001013014.2_39726001_3 - 3.9e-35 119.4 0.1 5.1e-33 112.6 0.0 4.0 5 1 0 5 5 5 1 Cadherin-like Cadherin_C_2 PF16492.3 001013014.2_39726001_3 - 2.6e-26 92.1 0.1 2.6e-26 92.1 0.1 1.9 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001013014.2_39726001_3 - 1.9e-06 27.7 2.2 0.0029 17.5 0.1 4.4 4 1 1 5 5 5 2 Cadherin-like DUF3823 PF12866.5 001013014.2_39726001_3 - 0.18 11.5 0.0 0.33 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3823) p450 PF00067.20 001171122.1_37925001_3 - 8.3e-164 545.6 0.1 9.9e-164 545.3 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3916 PF13079.4 001171122.1_37925001_3 - 0.048 13.4 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3916) RRM_1 PF00076.20 001133550.1_43524001_1 - 1e-26 92.4 0.0 3.9e-13 48.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MHC_I_3 PF16497.3 001172855.1_09922001_1 - 2e-76 255.8 0.0 2.4e-76 255.5 0.0 1.1 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001172855.1_09922001_1 - 1.7e-10 41.1 0.0 3.4e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001172855.1_09922001_1 - 0.0061 16.0 0.0 0.011 15.2 0.0 1.4 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Proteasome PF00227.24 001131340.1_43523001_1 - 4.7e-52 176.1 0.0 6e-52 175.8 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.7 001131340.1_43523001_1 - 4.4e-13 48.5 0.0 7.9e-13 47.7 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Cyt-b5 PF00173.26 001171263.1_37921001_2 - 7.1e-23 80.4 0.1 9.6e-23 80.0 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain IL3 PF02059.13 001135634.1_39722001_2 - 3.5e-43 146.3 0.5 4.5e-43 145.9 0.5 1.1 1 0 0 1 1 1 1 Interleukin-3 Ldl_recept_b PF00058.15 001135634.1_39722001_2 - 0.08 13.3 0.1 0.15 12.4 0.1 1.4 1 0 0 1 1 1 0 Low-density lipoprotein receptor repeat class B Sugar_tr PF00083.22 001131889.2_43528001_2 - 2.2e-16 59.6 2.6 2.2e-16 59.6 2.6 1.5 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.14 001131889.2_43528001_2 - 2.2e-15 56.3 4.4 2.2e-15 56.3 4.4 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily 7tm_1 PF00001.19 001172862.1_09923001_3 - 4.3e-58 196.5 24.4 6.1e-58 196.0 24.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001172862.1_09923001_3 - 0.0063 16.2 23.0 0.019 14.6 23.0 1.9 1 1 0 1 1 1 1 Olfactory receptor TctB PF07331.9 001172862.1_09923001_3 - 0.034 14.3 15.9 0.017 15.2 6.2 2.4 2 1 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family p450 PF00067.20 001170921.2_37924001_2 - 1.5e-103 346.9 0.1 2e-103 346.5 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 7tm_1 PF00001.19 001122935.1_37923001_1 - 1.8e-23 83.0 8.2 2.4e-23 82.6 8.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 001122935.1_37923001_1 - 6e-05 22.4 5.5 6.7e-05 22.2 0.6 2.2 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srbc PF10316.7 001122935.1_37923001_1 - 0.00019 20.9 0.1 0.00019 20.9 0.1 2.1 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc WBP-1 PF11669.6 001122935.1_37923001_1 - 1.2 9.7 3.4 13 6.3 0.1 2.9 1 1 2 3 3 3 0 WW domain-binding protein 1 DUF898 PF05987.11 001122935.1_37923001_1 - 2.6 6.9 13.6 1.1 8.1 11.1 1.5 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF898) EGF_CA PF07645.13 001131903.1_43525001_2 - 1.1e-43 147.0 90.3 4.8e-11 42.6 8.5 7.7 9 0 0 9 9 9 6 Calcium-binding EGF domain cEGF PF12662.5 001131903.1_43525001_2 - 5.6e-38 128.3 45.2 1.5e-11 43.9 2.9 7.2 6 0 0 6 6 6 6 Complement Clr-like EGF-like FXa_inhibition PF14670.4 001131903.1_43525001_2 - 1.7e-24 85.7 91.7 3e-09 36.9 6.2 8.3 8 1 0 8 8 8 5 Coagulation Factor Xa inhibitory site EGF_3 PF12947.5 001131903.1_43525001_2 - 4e-13 49.2 62.3 2.6e-06 27.4 4.6 7.5 7 0 0 7 7 7 5 EGF domain hEGF PF12661.5 001131903.1_43525001_2 - 0.0012 19.3 73.2 0.0037 17.8 3.6 8.4 8 1 0 8 8 8 4 Human growth factor-like EGF Plasmod_Pvs28 PF06247.9 001131903.1_43525001_2 - 0.0026 17.9 41.9 0.022 14.9 5.4 5.6 5 0 0 5 5 5 3 Pvs28 EGF domain EGF PF00008.25 001131903.1_43525001_2 - 0.0039 17.3 21.6 0.0045 17.1 7.5 7.8 8 0 0 8 8 8 4 EGF-like domain p450 PF00067.20 001173069.1_09925001_2 - 2.2e-128 428.8 3.0 2.5e-128 428.6 3.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_C48 PF02902.17 001131526.1_43527001_3 - 8e-40 136.9 2.1 1.3e-39 136.1 2.1 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Ank_4 PF13637.4 001132678.1_43526001_2 - 9.8e-20 70.5 0.6 7.2e-10 39.1 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.5 001132678.1_43526001_2 - 4.5e-14 52.7 0.1 3.7e-12 46.5 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001132678.1_43526001_2 - 1.4e-12 47.4 0.3 7.2e-11 42.0 0.2 2.8 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.28 001132678.1_43526001_2 - 4.3e-09 36.3 4.2 0.00071 19.8 0.2 4.2 3 1 1 4 4 4 2 Ankyrin repeat Ank_3 PF13606.4 001132678.1_43526001_2 - 1.9e-08 33.7 0.2 0.0023 18.1 0.1 4.4 4 0 0 4 4 4 1 Ankyrin repeat Radical_SAM PF04055.19 001131387.1_43527001_2 - 2.9e-28 99.2 0.0 5e-28 98.4 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Wyosine_form PF08608.10 001131387.1_43527001_2 - 3.4e-26 91.2 0.1 6.3e-26 90.4 0.1 1.5 1 0 0 1 1 1 1 Wyosine base formation Flavodoxin_1 PF00258.23 001131387.1_43527001_2 - 6e-26 91.2 0.0 1.1e-25 90.4 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin p450 PF00067.20 001171266.1_37924001_1 - 4.2e-157 523.5 0.2 4.8e-157 523.3 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 CK_II_beta PF01214.16 001160283.1_37922001_3 - 1.4e-86 288.9 0.0 1.6e-86 288.7 0.0 1.0 1 0 0 1 1 1 1 Casein kinase II regulatory subunit CCDC24 PF15669.3 001160283.1_37922001_3 - 0.091 12.5 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family Ank_2 PF12796.5 172939.3_32929001_3 - 6.3e-13 49.0 0.0 1.1e-12 48.2 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.4 172939.3_32929001_3 - 8.9e-13 48.1 0.7 2e-08 34.2 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.4 172939.3_32929001_3 - 1.8e-12 47.4 0.3 4.4e-12 46.1 0.3 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.28 172939.3_32929001_3 - 2.1e-11 43.6 0.5 1.7e-07 31.2 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.4 172939.3_32929001_3 - 8.4e-09 34.9 0.3 3.6e-05 23.7 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Serpin PF00079.18 001172734.1_09923001_1 - 2.2e-116 389.1 1.9 2.5e-116 388.9 1.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) YpzG PF14139.4 001172734.1_09923001_1 - 0.063 13.3 0.0 0.19 11.8 0.0 1.8 1 0 0 1 1 1 0 YpzG-like protein tRNA-synt_2d PF01409.18 001133695.2_43524001_2 - 1.5e-90 302.9 0.0 2e-90 302.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) MarR_2 PF12802.5 001133695.2_43524001_2 - 6.3e-05 22.7 0.5 0.00024 20.8 0.5 2.0 1 0 0 1 1 1 1 MarR family HTH_11 PF08279.10 001133695.2_43524001_2 - 0.00022 21.0 0.0 0.00042 20.1 0.0 1.4 1 0 0 1 1 1 1 HTH domain tRNA-synt_2 PF00152.18 001133695.2_43524001_2 - 0.0012 17.8 0.3 0.004 16.1 0.0 1.9 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) MHC_I_3 PF16497.3 001172854.1_09922001_1 - 8.8e-73 243.9 2.3 1.1e-72 243.6 2.3 1.1 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001172854.1_09922001_1 - 9.4e-11 41.9 0.0 2.2e-10 40.7 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001172854.1_09922001_1 - 0.00017 21.1 0.4 0.00062 19.2 0.0 1.9 2 0 0 2 2 2 1 Class I Histocompatibility antigen, domains alpha 1 and 2 UPF0560 PF10577.7 001172854.1_09922001_1 - 0.055 11.8 1.8 0.078 11.3 1.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 p450 PF00067.20 001171128.1_37924001_2 - 2.2e-131 438.6 0.0 2.7e-131 438.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Med26 PF08711.9 001123165.1_49826001_1 - 1.7e-08 34.2 0.7 3.2e-08 33.3 0.7 1.5 1 0 0 1 1 1 1 TFIIS helical bundle-like domain zf-CCCH PF00642.22 001123165.1_49826001_1 - 1.3e-05 24.8 4.1 2.3e-05 24.0 4.1 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) SLC12 PF03522.13 001170971.1_37929001_1 - 6e-151 503.0 0.1 8.1e-151 502.6 0.1 1.2 1 0 0 1 1 1 1 Solute carrier family 12 AA_permease PF00324.19 001170971.1_37929001_1 - 2.9e-150 500.9 39.8 3.5e-150 500.6 39.8 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_N PF08403.8 001170971.1_37929001_1 - 3.4e-33 112.8 0.0 3.7e-32 109.5 0.1 2.3 2 0 0 2 2 2 1 Amino acid permease N-terminal AA_permease_2 PF13520.4 001170971.1_37929001_1 - 7.8e-21 74.3 45.9 1.2e-20 73.6 45.9 1.2 1 0 0 1 1 1 1 Amino acid permease IL8 PF00048.18 001173399.2_09923001_3 - 9.5e-15 54.4 1.5 1.8e-14 53.5 1.5 1.4 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like p450 PF00067.20 001171049.1_37924001_2 - 2.2e-146 488.1 1.6 2.5e-146 487.9 1.6 1.0 1 0 0 1 1 1 1 Cytochrome P450 Wap1 PF16997.3 001171049.1_37924001_2 - 0.0038 16.3 0.0 0.0057 15.7 0.0 1.2 1 0 0 1 1 1 1 Wap1 domain zf-H2C2_2 PF13465.4 001135617.1_39723001_1 - 3.8e-48 159.7 54.5 2.9e-09 36.8 1.9 8.7 8 0 0 8 8 8 8 Zinc-finger double domain SCAN PF02023.15 001135617.1_39723001_1 - 8.5e-43 144.0 4.3 1.5e-42 143.2 4.3 1.4 1 0 0 1 1 1 1 SCAN domain zf-C2H2 PF00096.24 001135617.1_39723001_1 - 3.4e-42 140.4 61.2 5.9e-07 29.5 0.6 7.4 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001135617.1_39723001_1 - 1.5e-21 75.0 56.3 0.0014 19.1 0.2 7.6 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001135617.1_39723001_1 - 6.5e-09 35.3 41.0 0.0001 21.8 0.0 6.9 7 0 0 7 7 7 4 zinc-finger C2H2-type Zn-ribbon_8 PF09723.8 001135617.1_39723001_1 - 1.9e-08 34.1 27.0 0.0037 17.2 2.1 5.5 3 2 2 5 5 5 4 Zinc ribbon domain zf-C2H2_6 PF13912.4 001135617.1_39723001_1 - 3.3e-07 30.0 45.8 0.0023 17.7 0.5 7.0 7 0 0 7 7 7 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001135617.1_39723001_1 - 1.2e-05 25.3 34.0 0.048 13.9 0.4 6.7 7 0 0 7 7 7 3 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 001135617.1_39723001_1 - 2.8e-05 24.7 22.3 0.037 14.6 2.2 4.6 3 1 3 6 6 5 4 zinc-ribbon family XPA_N PF01286.16 001135617.1_39723001_1 - 0.00013 21.8 27.5 1.5 8.8 0.3 7.2 7 0 0 7 7 7 2 XPA protein N-terminal zf-trcl PF13451.4 001135617.1_39723001_1 - 0.0011 18.6 26.4 5.2 6.9 0.1 7.4 7 1 0 7 7 7 1 Probable zinc-ribbon domain DZR PF12773.5 001135617.1_39723001_1 - 0.0013 18.6 24.6 0.062 13.2 0.6 4.0 2 1 0 2 2 2 1 Double zinc ribbon DNA_RNApol_7kD PF03604.11 001135617.1_39723001_1 - 0.0066 16.0 21.2 1.4 8.5 0.2 6.4 6 0 0 6 6 6 1 DNA directed RNA polymerase, 7 kDa subunit PknG_rubred PF16919.3 001135617.1_39723001_1 - 0.018 15.1 0.5 0.018 15.1 0.5 4.2 2 1 3 5 5 5 0 Protein kinase G rubredoxin domain HypA PF01155.17 001135617.1_39723001_1 - 0.05 13.5 19.1 1 9.3 0.9 4.0 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-AN1 PF01428.14 001135617.1_39723001_1 - 0.07 13.2 37.4 2.8 8.0 5.0 7.3 5 1 2 7 7 7 0 AN1-like Zinc finger HTH_18 PF12833.5 001135617.1_39723001_1 - 0.071 13.2 0.6 56 4.0 0.0 4.0 4 0 0 4 4 3 0 Helix-turn-helix domain zf-met PF12874.5 001135617.1_39723001_1 - 0.13 12.5 0.2 0.13 12.5 0.2 6.4 6 0 0 6 6 6 0 Zinc-finger of C2H2 type DUF3720 PF12517.6 001135617.1_39723001_1 - 0.25 12.2 3.5 0.72 10.7 3.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3720) zf-BED PF02892.13 001135617.1_39723001_1 - 0.59 10.1 47.4 3.4 7.7 4.0 6.4 2 2 4 6 6 6 0 BED zinc finger C1_4 PF07975.10 001135617.1_39723001_1 - 0.64 10.2 29.4 6.7 6.9 1.6 4.7 1 1 5 6 6 6 0 TFIIH C1-like domain DUF3268 PF11672.6 001135617.1_39723001_1 - 2.4 8.4 20.0 2.1 8.6 1.0 3.6 2 1 1 4 4 4 0 zinc-finger-containing domain FYVE PF01363.19 001135617.1_39723001_1 - 3.4 7.7 36.7 12 6.0 12.2 4.9 1 1 2 3 3 2 0 FYVE zinc finger YhfH PF14149.4 001135617.1_39723001_1 - 8.1 6.4 29.2 13 5.8 0.3 6.7 7 0 0 7 7 7 0 YhfH-like protein zinc_ribbon_9 PF14369.4 001135617.1_39723001_1 - 8.3 6.6 21.4 1.6 8.9 2.5 5.9 6 0 0 6 6 6 0 zinc-ribbon Catalase PF00199.17 001172925.1_09926001_3 - 3.3e-195 648.4 0.0 4.4e-195 648.0 0.0 1.2 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.10 001172925.1_09926001_3 - 1.4e-18 66.8 0.7 4.1e-18 65.2 0.2 2.0 2 0 0 2 2 2 1 Catalase-related immune-responsive Lipase_GDSL PF00657.20 001173028.1_09929001_1 - 4.8e-76 255.1 0.0 1.4e-29 103.3 0.0 4.3 4 1 0 4 4 4 3 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.4 001173028.1_09929001_1 - 7.9e-23 81.6 2.4 4.3e-06 27.1 0.1 4.9 4 3 0 4 4 4 3 GDSL-like Lipase/Acylhydrolase family Transglut_C PF00927.20 001173028.1_09929001_1 - 0.017 15.1 0.0 0.043 13.8 0.0 1.6 1 0 0 1 1 1 0 Transglutaminase family, C-terminal ig like domain GST_N PF02798.18 001134015.1_43523001_1 - 1.1e-20 73.6 0.0 1.1e-20 73.6 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 001134015.1_43523001_1 - 3.3e-16 59.2 0.0 3.3e-16 59.2 0.0 2.5 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 001134015.1_43523001_1 - 2.8e-15 56.2 0.0 2.8e-15 56.2 0.0 2.5 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.2 001134015.1_43523001_1 - 1.3e-05 24.8 0.5 0.00013 21.6 0.1 2.5 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 001134015.1_43523001_1 - 0.00029 20.6 0.0 0.00076 19.2 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 001134015.1_43523001_1 - 0.013 15.7 0.0 0.03 14.6 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Bromo_TP PF07524.11 001134015.1_43523001_1 - 0.2 11.6 0.0 0.39 10.6 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated SR-25 PF10500.7 001134015.1_43523001_3 - 4.4 6.7 32.0 5.7 6.3 32.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MFS_1 PF07690.14 001131238.1_43526001_3 - 7.6e-13 48.0 26.0 3e-11 42.7 13.5 2.5 2 1 0 3 3 3 2 Major Facilitator Superfamily BNIP2 PF12496.6 001133444.1_43529001_3 - 4e-40 137.3 2.7 6.7e-40 136.5 2.7 1.3 1 0 0 1 1 1 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CRAL_TRIO_2 PF13716.4 001133444.1_43529001_3 - 1.6e-31 109.1 0.1 2.6e-31 108.4 0.1 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.18 001133444.1_43529001_3 - 2.4e-07 30.5 0.1 4.2e-07 29.7 0.1 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain Pkinase_Tyr PF07714.15 001133894.1_43529001_1 - 8.6e-78 261.1 0.0 1.2e-77 260.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.22 001133894.1_43529001_1 - 5.3e-62 206.7 0.4 6.1e-30 103.5 0.0 2.4 2 0 0 2 2 2 2 Receptor L domain GF_recep_IV PF14843.4 001133894.1_43529001_1 - 7e-54 181.0 79.8 2.9e-48 162.8 29.0 4.2 2 1 0 2 2 2 2 Growth factor receptor domain IV Furin-like PF00757.18 001133894.1_43529001_1 - 5.6e-35 120.3 90.5 4.1e-31 107.8 36.7 4.8 3 1 2 5 5 5 3 Furin-like cysteine rich region Pkinase PF00069.23 001133894.1_43529001_1 - 9.2e-33 113.6 0.0 1.4e-32 112.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.4 001133894.1_43529001_1 - 0.031 13.5 0.0 0.062 12.5 0.0 1.4 1 0 0 1 1 1 0 Kinase-like RRM_1 PF00076.20 001133859.2_43524001_2 - 3.9e-32 109.8 0.0 5.8e-15 54.7 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001133859.2_43524001_2 - 6.5e-09 35.7 0.0 0.00061 19.7 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.4 001133859.2_43524001_2 - 0.056 13.3 0.1 0.5 10.3 0.1 2.2 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif OB_RNB PF08206.9 001133859.2_43524001_2 - 0.065 12.8 0.4 1.2 8.7 0.1 2.5 2 0 0 2 2 2 0 Ribonuclease B OB domain FKBP_C PF00254.26 001171126.1_37921001_1 - 8.1e-35 118.9 0.0 9.4e-35 118.7 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Septin PF00735.16 001135363.1_43526001_3 - 3.1e-122 407.1 0.1 3.1e-122 407.1 0.1 1.6 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.21 001135363.1_43526001_3 - 1.6e-06 28.1 0.1 4.6e-06 26.6 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.14 001135363.1_43526001_3 - 1.7e-05 24.6 9.2 0.00037 20.3 0.0 3.3 3 0 0 3 3 3 2 Protein of unknown function, DUF258 AIG1 PF04548.14 001135363.1_43526001_3 - 0.0038 16.4 0.0 0.0038 16.4 0.0 2.0 2 0 0 2 2 1 1 AIG1 family Exonuc_VII_L PF02601.13 001135363.1_43526001_3 - 0.016 14.7 9.9 0.023 14.1 9.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit AAA_22 PF13401.4 001135363.1_43526001_3 - 0.023 14.8 0.0 0.068 13.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.4 001135363.1_43526001_3 - 0.029 14.6 0.3 0.069 13.4 0.0 1.7 2 0 0 2 2 1 0 AAA ATPase domain Ras PF00071.20 001135363.1_43526001_3 - 0.04 13.4 0.9 0.061 12.8 0.0 1.7 2 0 0 2 2 2 0 Ras family AAA_29 PF13555.4 001135363.1_43526001_3 - 0.071 12.7 0.1 0.15 11.7 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.25 001135363.1_43526001_3 - 0.083 13.3 0.0 0.083 13.3 0.0 2.4 2 0 0 2 2 2 0 ABC transporter FeoB_N PF02421.16 001135363.1_43526001_3 - 0.084 12.3 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B GTP_EFTU PF00009.25 001135363.1_43526001_3 - 0.17 11.2 9.2 2.2 7.7 0.1 3.7 3 1 0 3 3 3 0 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.10 001135363.1_43526001_3 - 0.18 11.0 0.0 0.18 11.0 0.0 2.6 3 0 0 3 3 2 0 Gtr1/RagA G protein conserved region Fez1 PF06818.13 001135363.1_43526001_3 - 2.1 8.6 26.5 0.14 12.4 21.4 1.5 2 0 0 2 2 2 0 Fez1 DUF87 PF01935.15 001135363.1_43526001_3 - 7 6.5 9.5 76 3.1 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function DUF87 Peptidase_C1 PF00112.21 001122871.1_22423001_2 - 5.9e-54 183.3 0.2 7.9e-54 182.9 0.2 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 001122871.1_22423001_2 - 1.3e-11 44.6 0.1 2.1e-11 43.9 0.1 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Hs1pro-1_N PF07231.10 001122871.1_22423001_2 - 0.17 11.5 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 Hs1pro-1 N-terminus p450 PF00067.20 001171070.1_37925001_1 - 4.6e-128 427.7 0.0 5.7e-128 427.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF2338 PF10100.7 001171070.1_37925001_1 - 0.09 11.2 0.0 0.13 10.7 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2338) F-box-like PF12937.5 001129738.1_39523001_1 - 1.1e-10 41.0 1.1 3.1e-10 39.6 1.1 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001129738.1_39523001_1 - 1.8e-09 37.1 1.3 5.9e-09 35.5 1.3 2.0 1 0 0 1 1 1 1 F-box domain LRR_6 PF13516.4 001129738.1_39523001_1 - 0.44 10.6 2.4 49 4.2 0.1 3.7 4 0 0 4 4 4 0 Leucine Rich repeat p450 PF00067.20 001171121.1_37924001_2 - 1e-99 334.3 0.0 1.3e-99 334.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 adh_short_C2 PF13561.4 001172942.1_09922001_1 - 1e-53 182.2 0.2 1.2e-53 182.0 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.23 001172942.1_09922001_1 - 6e-47 159.5 0.6 7.3e-47 159.2 0.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.19 001172942.1_09922001_1 - 8.3e-06 25.3 0.1 5.4e-05 22.6 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.4 001172942.1_09922001_1 - 7.4e-05 22.6 0.6 0.00013 21.9 0.4 1.3 1 1 0 1 1 1 1 NAD(P)H-binding KR PF08659.8 001172942.1_09922001_1 - 8e-05 22.5 0.7 0.00012 21.9 0.7 1.2 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.18 001172942.1_09922001_1 - 0.0008 19.4 0.1 0.0019 18.1 0.0 1.7 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase RmlD_sub_bind PF04321.15 001172942.1_09922001_1 - 0.0053 15.8 0.3 0.0074 15.3 0.3 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Sacchrp_dh_NADP PF03435.16 001172942.1_09922001_1 - 0.0081 16.3 0.5 0.038 14.1 0.1 2.0 1 1 1 2 2 2 1 Saccharopine dehydrogenase NADP binding domain THF_DHG_CYH_C PF02882.17 001172942.1_09922001_1 - 0.031 13.5 0.3 0.1 11.8 0.0 2.0 2 1 1 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 2-Hacid_dh_C PF02826.17 001172942.1_09922001_1 - 0.059 12.6 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Atg8 PF02991.14 001133707.1_43524001_2 - 7.7e-48 160.9 0.2 1.1e-47 160.4 0.2 1.2 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.11 001133707.1_43524001_2 - 2.3e-06 27.8 0.0 3.7e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 PLA2_B PF01735.16 001132692.1_43526001_2 - 1.8e-146 488.2 0.0 2.3e-146 487.9 0.0 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain C2 PF00168.28 001132692.1_43526001_2 - 2.7e-16 59.6 0.1 6e-16 58.5 0.1 1.6 1 0 0 1 1 1 1 C2 domain Prp18 PF02840.13 001131478.2_43524001_1 - 7.2e-63 210.8 0.2 1.3e-62 209.9 0.2 1.5 1 0 0 1 1 1 1 Prp18 domain PRP4 PF08799.9 001131478.2_43524001_1 - 1.5e-13 49.9 6.8 1.9e-13 49.6 3.5 2.4 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like p450 PF00067.20 001170977.1_37925001_1 - 2.2e-128 428.8 0.0 2.6e-128 428.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 AMP-binding PF00501.26 001134109.1_43528001_2 - 5.4e-102 341.4 0.0 7.3e-102 341.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 001134109.1_43528001_2 - 9.4e-05 23.2 0.1 0.00027 21.7 0.1 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain 7tm_1 PF00001.19 001172733.1_09925001_1 - 1.9e-60 204.2 13.6 2.5e-60 203.9 13.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001172733.1_09925001_1 - 3.6e-13 49.4 12.0 1.6e-12 47.3 12.0 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001172733.1_09925001_1 - 5.3e-09 36.1 12.3 1.4e-08 34.7 12.3 1.6 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001172733.1_09925001_1 - 0.11 11.7 20.1 0.25 10.5 19.9 1.7 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx Ni_hydr_CYTB PF01292.18 001172733.1_09925001_1 - 0.2 11.1 0.1 0.2 11.1 0.1 1.9 2 0 0 2 2 2 0 Prokaryotic cytochrome b561 DUF2417 PF10329.7 001172733.1_09925001_1 - 1.6 7.9 6.7 23 4.1 5.5 2.3 2 0 0 2 2 2 0 Region of unknown function (DUF2417) RtcB PF01139.15 001122986.2_49824001_3 - 5.1e-146 486.9 0.2 6e-146 486.7 0.2 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB GBP_C PF02841.12 001132053.1_43525001_1 - 3.7e-126 420.4 26.8 4.8e-126 420.0 26.8 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain GBP PF02263.17 001132053.1_43525001_1 - 5.3e-124 412.5 0.0 5.3e-124 412.5 0.0 3.1 3 1 0 3 3 3 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.21 001132053.1_43525001_1 - 0.0025 17.7 0.5 0.0073 16.3 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase FlgT_C PF16538.3 001132053.1_43525001_1 - 0.034 14.5 0.4 0.093 13.1 0.4 1.7 1 0 0 1 1 1 0 Flagellar assembly protein T, C-terminal domain zf-NPL4 PF05020.13 001132053.1_43525001_1 - 0.061 13.3 5.5 4.5 7.3 0.1 2.4 2 0 0 2 2 2 0 NPL4 family, putative zinc binding region Pep_M12B_propep PF01562.17 001132053.1_43525001_1 - 0.69 10.0 4.0 1.4 9.1 2.6 2.1 2 0 0 2 2 2 0 Reprolysin family propeptide PTH2 PF01981.14 001132053.1_43525001_1 - 1.1 9.4 6.8 2.3 8.3 0.1 2.5 2 0 0 2 2 2 0 Peptidyl-tRNA hydrolase PTH2 p450 PF00067.20 001171072.1_37925001_3 - 8.6e-105 351.0 0.0 1.1e-104 350.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cathelicidins PF00666.15 001123150.1_49822001_1 - 1.3e-49 166.5 0.2 1.7e-49 166.2 0.2 1.1 1 0 0 1 1 1 1 Cathelicidin Spp-24 PF07448.9 001123150.1_49822001_1 - 0.00025 21.0 0.2 0.00041 20.3 0.2 1.4 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Hydrolase_6 PF13344.4 001134189.1_43525001_2 - 5.6e-18 64.8 0.0 9.5e-18 64.0 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.4 001134189.1_43525001_2 - 2e-17 62.9 0.0 3.6e-17 62.1 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.4 001134189.1_43525001_2 - 3.5e-06 27.1 0.0 0.00012 22.1 0.0 2.1 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.24 001134189.1_43525001_2 - 0.00019 21.6 0.2 0.036 14.2 0.0 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase ADH_zinc_N PF00107.24 001132761.1_43526001_3 - 4.2e-22 78.3 0.1 7.2e-22 77.5 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 001132761.1_43526001_3 - 1.3e-21 76.4 1.5 2.9e-21 75.2 1.5 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.4 001132761.1_43526001_3 - 0.0026 18.7 0.0 0.004 18.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.12 001132761.1_43526001_3 - 0.018 14.5 0.0 0.028 13.9 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.17 001132761.1_43526001_3 - 0.024 13.9 0.1 0.061 12.5 0.1 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IGFBP PF00219.16 001132761.1_43526001_3 - 0.026 15.0 0.2 0.074 13.6 0.2 1.7 1 0 0 1 1 1 0 Insulin-like growth factor binding protein TrkA_N PF02254.16 001132761.1_43526001_3 - 0.091 12.9 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain Insulin PF00049.16 001172966.1_09922001_3 - 3.9e-15 56.5 4.8 1.3e-12 48.4 4.8 2.4 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family p450 PF00067.20 001171130.1_37925001_3 - 3.2e-146 487.6 0.0 3.8e-146 487.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ig_2 PF13895.4 001173049.1_09924001_3 - 4.3e-21 74.9 0.4 1e-11 44.9 0.2 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001173049.1_09924001_3 - 1.2e-14 54.5 0.2 1.1e-06 29.0 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001173049.1_09924001_3 - 3.7e-05 23.7 1.2 0.014 15.4 0.1 3.3 2 2 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 001173049.1_09924001_3 - 0.0011 18.9 0.2 1.8 8.5 0.1 3.4 2 2 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.15 001173049.1_09924001_3 - 0.022 14.8 0.8 14 5.8 0.0 3.6 3 1 1 4 4 4 0 Immunoglobulin V-set domain DAG1 PF05454.9 001173049.1_09924001_3 - 0.047 12.9 0.2 0.07 12.4 0.2 1.1 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) Ig_4 PF16680.3 001173049.1_09924001_3 - 0.049 13.9 0.0 3.3 8.0 0.0 2.3 2 0 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain Shisa PF13908.4 001173049.1_09924001_3 - 0.058 13.5 0.1 0.091 12.9 0.1 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator RnaseA PF00074.18 001164591.1_40422001_1 - 4.7e-24 85.1 3.9 5.9e-24 84.8 3.9 1.1 1 0 0 1 1 1 1 Pancreatic ribonuclease Bcl-2_3 PF15286.4 001164591.1_40422001_1 - 0.13 12.8 0.0 0.21 12.1 0.0 1.3 1 0 0 1 1 1 0 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like ADH_zinc_N PF00107.24 001172936.1_09924001_2 - 2.5e-26 92.0 0.8 3.9e-26 91.3 0.2 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.4 001172936.1_09924001_2 - 7.4e-19 69.0 0.0 1.1e-18 68.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 001172936.1_09924001_2 - 4.9e-11 42.4 0.0 2.7e-10 40.0 0.0 2.2 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Eno-Rase_NADH_b PF12242.6 001172936.1_09924001_2 - 0.058 13.0 0.8 0.16 11.6 0.8 1.7 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase adh_short PF00106.23 001172936.1_09924001_2 - 0.09 12.1 0.5 0.17 11.1 0.5 1.5 1 0 0 1 1 1 0 short chain dehydrogenase DUF3361 PF11841.6 001133064.1_43528001_3 - 2.9e-58 196.1 6.7 4.6e-58 195.4 6.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) ELMO_CED12 PF04727.11 001133064.1_43528001_3 - 2.9e-40 138.1 0.1 4.6e-40 137.5 0.1 1.3 1 0 0 1 1 1 1 ELMO/CED-12 family PH_12 PF16457.3 001133064.1_43528001_3 - 8.2e-33 113.7 0.0 2.1e-32 112.4 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain SIL1 PF16782.3 001133064.1_43528001_3 - 0.012 14.7 2.9 0.025 13.7 2.9 1.5 1 1 0 1 1 1 0 Nucleotide exchange factor SIL1 SelP_N PF04592.12 001133990.1_43525001_3 - 5.3e-101 336.8 4.6 5.3e-101 336.8 4.6 1.4 1 1 1 2 2 2 2 Selenoprotein P, N terminal region SelP_C PF04593.12 001133990.1_43525001_3 - 3.8e-44 149.8 12.3 9e-44 148.6 12.3 1.6 1 0 0 1 1 1 1 Selenoprotein P, C terminal region MIP PF00230.18 001159758.1_39522001_1 - 3.2e-81 272.2 14.3 3.8e-81 272.0 14.3 1.0 1 0 0 1 1 1 1 Major intrinsic protein ThiF PF00899.19 001132564.1_43525001_2 - 1.2e-47 162.2 0.1 1.7e-47 161.7 0.1 1.1 1 0 0 1 1 1 1 ThiF family UDPG_MGDP_dh_N PF03721.12 001132564.1_43525001_2 - 0.0075 15.7 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pox_A_type_inc PF04508.10 001132564.1_43525001_2 - 0.025 14.3 2.6 0.091 12.5 2.6 2.0 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Sacchrp_dh_NADP PF03435.16 001132564.1_43525001_2 - 0.037 14.1 0.6 0.93 9.6 0.6 2.4 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DUF3930 PF13067.4 001132564.1_43525001_2 - 0.061 13.2 0.2 0.14 12.0 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3930) FAD_binding_3 PF01494.17 001132564.1_43525001_2 - 0.21 10.7 0.3 0.31 10.1 0.3 1.2 1 0 0 1 1 1 0 FAD binding domain Phospholip_A2_1 PF00068.17 001173000.1_09922001_3 - 5.6e-36 123.2 16.4 7.2e-36 122.8 16.4 1.1 1 0 0 1 1 1 1 Phospholipase A2 Parvo_coat_N PF08398.8 001173000.1_09922001_3 - 0.014 15.4 0.0 0.044 13.8 0.0 1.8 2 0 0 2 2 2 0 Parvovirus coat protein VP1 Phospholip_A2_2 PF05826.10 001173000.1_09922001_3 - 0.96 9.6 16.9 21 5.3 16.9 2.2 1 1 0 1 1 1 0 Phospholipase A2 Ysc84 PF04366.10 001131564.1_43525001_1 - 6e-40 135.8 0.0 8.7e-40 135.3 0.0 1.2 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.26 001131564.1_43525001_1 - 3.7e-15 55.1 0.0 6.7e-15 54.3 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 001131564.1_43525001_1 - 1.1e-14 53.9 0.0 1.8e-14 53.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001131564.1_43525001_1 - 1.3e-10 40.6 0.0 2.3e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain 2OG-FeII_Oxy PF03171.18 001133956.1_43526001_2 - 1.6e-06 28.4 0.0 6.6e-06 26.4 0.0 2.1 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Anp1 PF03452.12 001133956.1_43526001_2 - 2.1e-06 27.2 0.2 0.046 13.0 0.0 3.1 2 2 1 3 3 3 2 Anp1 2OG-FeII_Oxy_3 PF13640.4 001133956.1_43526001_2 - 0.00015 22.4 0.0 0.00034 21.3 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MHC_I_3 PF16497.3 001172744.1_09923001_1 - 3.4e-70 235.4 0.5 6e-70 234.6 0.5 1.4 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001172744.1_09923001_1 - 1.2e-11 44.7 0.0 1.2e-10 41.5 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001172744.1_09923001_1 - 0.014 15.8 0.2 0.055 14.0 0.2 2.0 1 1 1 2 2 2 0 Immunoglobulin domain ACBP PF00887.17 001133838.1_43529001_1 - 2.9e-26 91.4 0.1 6.3e-26 90.3 0.1 1.6 1 0 0 1 1 1 1 Acyl CoA binding protein SRP54 PF00448.20 001133440.1_43525001_1 - 1.7e-77 259.4 0.1 1.7e-77 259.4 0.1 2.4 3 0 0 3 3 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.17 001133440.1_43525001_1 - 4.5e-30 104.1 2.7 4.5e-30 104.1 2.7 3.4 2 1 1 3 3 1 1 Signal peptide binding domain SRP54_N PF02881.17 001133440.1_43525001_1 - 1.6e-20 72.9 3.1 1.6e-20 72.9 3.1 2.6 2 0 0 2 2 1 1 SRP54-type protein, helical bundle domain cobW PF02492.17 001133440.1_43525001_1 - 1.6e-06 27.7 0.8 1.6e-05 24.4 0.8 2.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.4 001133440.1_43525001_1 - 2.4e-06 27.6 0.0 4.8e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain CbiA PF01656.21 001133440.1_43525001_1 - 3.7e-05 23.6 0.0 0.00013 21.9 0.0 1.9 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain DUF2209 PF09974.7 001133440.1_43525001_1 - 0.00031 20.9 0.3 0.00072 19.8 0.3 1.6 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2209) AAA_17 PF13207.4 001133440.1_43525001_1 - 0.0016 18.7 0.1 0.0016 18.7 0.1 3.1 3 1 0 3 3 1 1 AAA domain CLP1_P PF16575.3 001133440.1_43525001_1 - 0.0035 17.0 0.7 1.2 8.7 0.1 2.7 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_30 PF13604.4 001133440.1_43525001_1 - 0.0095 15.5 0.1 0.025 14.2 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.4 001133440.1_43525001_1 - 0.0096 16.1 0.1 0.069 13.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain APS_kinase PF01583.18 001133440.1_43525001_1 - 0.0098 15.7 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_16 PF13191.4 001133440.1_43525001_1 - 0.019 15.2 0.0 0.043 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.27 001133440.1_43525001_1 - 0.028 14.7 1.0 0.22 11.8 0.0 2.9 2 2 1 3 3 2 0 ATPase family associated with various cellular activities (AAA) ArgK PF03308.14 001133440.1_43525001_1 - 0.032 13.1 0.0 0.032 13.1 0.0 2.6 3 0 0 3 3 2 0 ArgK protein AAA_28 PF13521.4 001133440.1_43525001_1 - 0.062 13.4 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.15 001133440.1_43525001_1 - 0.12 11.9 2.4 0.27 10.8 0.1 2.6 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein IL8 PF00048.18 001129946.1_49822001_1 - 1e-21 76.7 0.7 2.6e-21 75.4 0.7 1.7 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Cadherin PF00028.15 001024133.2_39726001_3 - 6.8e-81 266.7 0.0 1.5e-19 70.1 0.1 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001024133.2_39726001_3 - 3.3e-40 135.6 0.1 4.5e-35 119.2 0.1 5.2 5 1 0 5 5 5 2 Cadherin-like Cadherin_C_2 PF16492.3 001024133.2_39726001_3 - 1.3e-16 61.0 0.3 2.8e-16 59.9 0.3 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001024133.2_39726001_3 - 4.4e-06 26.5 5.8 0.063 13.2 0.0 5.4 6 0 0 6 6 6 2 Cadherin-like Ly49 PF08391.8 001024133.2_39726001_3 - 0.089 13.0 0.4 0.17 12.1 0.4 1.4 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region DUF1201 PF06716.9 001024133.2_39726001_3 - 0.37 10.7 2.8 0.77 9.7 2.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1201) MHC_I_3 PF16497.3 001123002.2_39523001_1 - 2.5e-70 235.9 0.0 3.1e-70 235.6 0.0 1.1 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.13 001123002.2_39523001_1 - 2.2e-11 43.9 0.0 5.7e-11 42.6 0.0 1.6 2 0 0 2 2 2 1 Immunoglobulin C1-set domain MHC_I PF00129.16 001123002.2_39523001_1 - 0.0053 16.2 0.0 0.0088 15.5 0.0 1.4 1 1 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Ig_3 PF13927.4 001123002.2_39523001_1 - 0.065 13.7 0.2 1.5 9.3 0.1 2.2 1 1 1 2 2 2 0 Immunoglobulin domain KASH PF10541.7 001123002.2_39523001_1 - 5.7 7.2 6.6 0.38 10.9 0.2 2.1 2 0 0 2 2 2 0 Nuclear envelope localisation domain Peptidase_S24 PF00717.21 001133848.2_43522001_2 - 6.6e-11 41.9 2.0 9.5e-11 41.4 0.2 2.1 2 0 0 2 2 2 1 Peptidase S24-like AP3D1 PF06375.9 001133848.2_43522001_2 - 0.12 12.6 22.8 0.18 11.9 22.8 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF4604 PF15377.4 001133848.2_43522001_2 - 1.5 9.1 23.2 1.3 9.3 21.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) RICTOR_N PF14664.4 001133848.2_43522001_2 - 1.8 7.3 7.9 13 4.5 0.0 2.1 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term Connexin PF00029.17 001133848.2_43522001_2 - 2.5 7.7 5.9 3.5 7.2 5.9 1.3 1 0 0 1 1 1 0 Connexin RNA_polI_A34 PF08208.9 001133848.2_43522001_3 - 2.5 8.0 30.9 3.4 7.6 30.9 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 IL4 PF00727.16 001163177.1_37921001_1 - 5.8e-46 155.1 0.3 6.7e-46 154.9 0.3 1.0 1 0 0 1 1 1 1 Interleukin 4 PI-PLC-X PF00388.17 001177733.1_32929001_1 - 1.5e-62 209.4 0.1 3.4e-62 208.2 0.1 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.17 001177733.1_32929001_1 - 3.4e-38 130.4 0.4 3.4e-38 130.4 0.4 1.9 2 0 0 2 2 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.9 001177733.1_32929001_1 - 2e-16 60.1 0.2 6.1e-16 58.6 0.2 1.9 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.28 001177733.1_32929001_1 - 5.5e-16 58.6 0.0 1.8e-15 57.0 0.0 1.9 1 0 0 1 1 1 1 C2 domain EF-hand_7 PF13499.4 001177733.1_32929001_1 - 8.3e-11 42.1 1.9 1.7e-10 41.1 0.4 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.30 001177733.1_32929001_1 - 9e-10 37.3 1.7 6e-05 22.2 0.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.4 001177733.1_32929001_1 - 4.5e-07 29.2 0.8 0.033 14.0 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_10 PF14788.4 001177733.1_32929001_1 - 3.3e-06 26.7 0.4 2.4e-05 24.0 0.1 2.4 1 1 1 2 2 2 2 EF hand PH_12 PF16457.3 001177733.1_32929001_1 - 5.4e-06 26.9 0.0 1.3e-05 25.6 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain EF-hand_5 PF13202.4 001177733.1_32929001_1 - 2.3e-05 23.6 0.3 0.0019 17.5 0.1 2.8 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.4 001177733.1_32929001_1 - 3.7e-05 23.3 0.3 0.015 14.9 0.1 2.6 1 1 1 2 2 2 2 EF-hand domain pair PH PF00169.27 001177733.1_32929001_1 - 0.0031 17.9 0.1 0.015 15.7 0.0 2.2 2 0 0 2 2 2 1 PH domain EF-hand_4 PF12763.5 001177733.1_32929001_1 - 0.016 15.1 0.1 0.044 13.6 0.1 1.8 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 001177733.1_32929001_1 - 0.019 15.2 0.1 0.045 13.9 0.1 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region A2M_comp PF07678.12 145779.2_45729001_2 - 8.8e-93 310.2 6.6 1.6e-92 309.3 6.6 1.4 1 0 0 1 1 1 1 A-macroglobulin complement component A2M_N_2 PF07703.12 145779.2_45729001_2 - 7.6e-33 113.6 0.5 2.4e-28 99.1 0.0 3.5 3 0 0 3 3 3 2 Alpha-2-macroglobulin family N-terminal region A2M_recep PF07677.12 145779.2_45729001_2 - 2.2e-28 98.7 1.4 9.6e-28 96.7 1.4 2.2 1 0 0 1 1 1 1 A-macroglobulin receptor A2M PF00207.20 145779.2_45729001_2 - 2.2e-27 94.6 0.0 9e-27 92.6 0.0 2.2 1 0 0 1 1 1 1 Alpha-2-macroglobulin family A2M_N PF01835.17 145779.2_45729001_2 - 8.4e-25 86.9 0.1 9.5e-21 73.9 0.0 3.4 3 0 0 3 3 3 2 MG2 domain Thiol-ester_cl PF10569.7 145779.2_45729001_2 - 1.6e-16 59.6 4.6 3.7e-16 58.4 4.6 1.7 1 0 0 1 1 1 1 Alpha-macro-globulin thiol-ester bond-forming region SVA PF05326.9 145779.2_45729001_2 - 0.00021 21.1 0.0 0.0011 18.8 0.0 2.3 2 0 0 2 2 2 1 Seminal vesicle autoantigen (SVA) Prenyltrans PF00432.19 145779.2_45729001_2 - 0.066 12.8 0.1 0.83 9.3 0.0 2.6 2 0 0 2 2 2 0 Prenyltransferase and squalene oxidase repeat Trypsin PF00089.24 001204060.1_39723001_1 - 6.4e-55 186.2 0.0 9.7e-55 185.6 0.0 1.3 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 001204060.1_39723001_1 - 0.057 13.7 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Phage_terminase PF10668.7 001204060.1_39723001_1 - 0.13 12.1 1.2 2.4 8.1 0.0 2.6 2 0 0 2 2 2 0 Phage terminase small subunit OLF PF02191.14 001082150.2_37925001_2 - 1.3e-83 280.2 0.0 1.7e-83 279.9 0.0 1.1 1 0 0 1 1 1 1 Olfactomedin-like domain IncA PF04156.12 001082150.2_37925001_2 - 0.00079 19.1 17.8 0.00079 19.1 17.8 2.1 1 1 1 2 2 2 1 IncA protein APG6 PF04111.10 001082150.2_37925001_2 - 0.0081 15.4 11.8 0.012 14.9 11.8 1.2 1 0 0 1 1 1 1 Autophagy protein Apg6 Leu_zip PF15294.4 001082150.2_37925001_2 - 0.014 14.8 6.1 0.023 14.1 6.1 1.3 1 0 0 1 1 1 0 Leucine zipper BRE1 PF08647.9 001082150.2_37925001_2 - 0.058 13.3 10.0 0.038 13.9 4.4 2.3 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase NYD-SP28_assoc PF14775.4 001082150.2_37925001_2 - 0.12 12.4 7.5 0.039 13.9 2.4 2.5 1 1 1 2 2 2 0 Sperm tail C-terminal domain DUF812 PF05667.9 001082150.2_37925001_2 - 0.14 10.9 9.2 0.2 10.3 9.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) EzrA PF06160.10 001082150.2_37925001_2 - 0.16 10.0 4.4 0.25 9.3 4.4 1.3 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA DUF1664 PF07889.10 001082150.2_37925001_2 - 0.28 11.0 2.7 14 5.6 0.0 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Cep57_MT_bd PF06657.11 001082150.2_37925001_2 - 0.42 10.9 13.4 0.051 13.9 8.7 1.9 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Syntaxin-6_N PF09177.9 001082150.2_37925001_2 - 0.59 10.6 5.2 0.89 10.0 3.9 2.0 2 1 0 2 2 1 0 Syntaxin 6, N-terminal DUF972 PF06156.11 001082150.2_37925001_2 - 0.6 10.6 6.1 0.55 10.7 4.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF972) TPR_MLP1_2 PF07926.10 001082150.2_37925001_2 - 0.6 10.0 15.2 1.6 8.6 15.2 1.6 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF5082 PF16888.3 001082150.2_37925001_2 - 0.65 10.2 8.8 0.24 11.6 4.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) Prominin PF05478.9 001082150.2_37925001_2 - 0.66 7.7 3.3 0.93 7.2 3.3 1.1 1 0 0 1 1 1 0 Prominin HALZ PF02183.16 001082150.2_37925001_2 - 0.83 9.8 10.4 0.67 10.1 7.1 2.4 1 1 1 2 2 2 0 Homeobox associated leucine zipper Mis14 PF08641.10 001082150.2_37925001_2 - 1.2 9.3 7.6 2.3 8.4 7.6 1.4 1 0 0 1 1 1 0 Kinetochore protein Mis14 like Spc7 PF08317.9 001082150.2_37925001_2 - 1.3 7.6 15.0 2.5 6.7 14.9 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF342 PF03961.11 001082150.2_37925001_2 - 1.7 7.0 5.3 2.5 6.5 5.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) V_ATPase_I PF01496.17 001082150.2_37925001_2 - 1.8 6.3 5.8 2.4 5.8 5.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HAUS-augmin3 PF14932.4 001082150.2_37925001_2 - 1.9 7.8 14.5 1 8.7 11.9 1.6 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 Spectrin PF00435.19 001082150.2_37925001_2 - 2.2 8.7 10.6 0.43 11.0 5.7 2.0 1 1 1 2 2 2 0 Spectrin repeat Golgin_A5 PF09787.7 001082150.2_37925001_2 - 2.5 7.4 14.1 3.7 6.8 14.1 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 FtsL PF04999.11 001082150.2_37925001_2 - 2.6 7.9 7.0 2.9 7.8 4.5 2.3 2 0 0 2 2 2 0 Cell division protein FtsL Exonuc_VII_L PF02601.13 001082150.2_37925001_2 - 3 7.2 8.6 4.6 6.6 8.6 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Kinetocho_Slk19 PF12709.5 001082150.2_37925001_2 - 5 7.5 8.9 6.7 7.1 1.8 2.9 1 1 2 3 3 3 0 Central kinetochore-associated GAS PF13851.4 001082150.2_37925001_2 - 5.1 6.3 14.2 42 3.3 14.2 2.1 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding bZIP_1 PF00170.19 001082150.2_37925001_2 - 5.3 7.1 11.7 7.3 6.6 2.1 2.6 1 1 1 2 2 2 0 bZIP transcription factor ADIP PF11559.6 001082150.2_37925001_2 - 7 6.6 19.6 1.6 8.7 13.4 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding CorA PF01544.16 001082150.2_37925001_2 - 9.5 5.3 7.1 15 4.7 7.1 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DivIC PF04977.13 001082150.2_37925001_2 - 9.5 5.9 17.8 21 4.9 6.4 3.4 1 1 2 3 3 3 0 Septum formation initiator Ig_2 PF13895.4 001271657.1_29622001_2 - 3.9e-21 75.1 1.6 5e-11 42.6 0.3 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001271657.1_29622001_2 - 1.4e-15 57.6 0.4 4.9e-08 33.3 0.2 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001271657.1_29622001_2 - 9.1e-10 38.4 2.0 0.00089 19.3 0.1 2.8 2 1 0 2 2 2 2 Immunoglobulin domain Ig_4 PF16680.3 001271657.1_29622001_2 - 4e-07 30.1 1.1 0.011 15.9 0.0 2.6 3 0 0 3 3 3 2 T-cell surface glycoprotein CD3 delta chain I-set PF07679.14 001271657.1_29622001_2 - 1.4e-06 28.1 0.2 0.023 14.6 0.1 3.3 2 2 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.15 001271657.1_29622001_2 - 0.00012 22.0 6.8 0.19 11.8 0.1 4.2 3 2 0 3 3 3 2 Immunoglobulin V-set domain Ig_5 PF16681.3 001271657.1_29622001_2 - 0.011 16.0 7.0 0.017 15.4 0.0 2.9 4 0 0 4 4 4 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 001271657.1_29622001_2 - 0.096 12.6 0.1 3.7 7.5 0.0 2.9 2 1 1 3 3 3 0 Izumo-like Immunoglobulin domain Filament PF00038.19 001244331.1_49828001_2 - 1.1e-102 343.7 44.8 1.1e-102 343.7 44.8 1.9 2 0 0 2 2 2 1 Intermediate filament protein Filament_head PF04732.12 001244331.1_49828001_2 - 1.3e-10 41.9 18.4 1.3e-10 41.9 18.4 2.3 2 0 0 2 2 2 1 Intermediate filament head (DNA binding) region TPR_MLP1_2 PF07926.10 001244331.1_49828001_2 - 0.0016 18.4 14.4 0.0016 18.4 14.4 5.0 3 1 2 5 5 5 2 TPR/MLP1/MLP2-like protein DUF1664 PF07889.10 001244331.1_49828001_2 - 0.13 12.1 20.1 0.02 14.7 2.3 4.5 4 1 1 5 5 5 0 Protein of unknown function (DUF1664) Lectin_N PF03954.12 001244331.1_49828001_2 - 2 8.0 16.6 2.9 7.5 1.3 3.6 2 1 0 3 3 3 0 Hepatic lectin, N-terminal domain Baculo_PEP_C PF04513.10 001244331.1_49828001_2 - 4.3 7.2 12.5 17 5.3 1.4 3.5 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Acylphosphatase PF00708.16 001190199.1_49822001_2 - 2.5e-23 82.2 0.2 2.5e-23 82.2 0.2 1.6 2 0 0 2 2 2 1 Acylphosphatase WD40 PF00400.30 022209.3_45724001_2 - 1.7e-08 34.8 3.7 9.5 7.1 0.0 6.7 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 022209.3_45724001_2 - 0.0006 19.9 0.1 4.4 7.5 0.0 4.2 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain zf-CCCH_3 PF15663.3 001024352.1_45724001_3 - 1.3e-39 134.7 6.3 1.3e-39 134.7 6.3 2.1 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH_2 PF14608.4 001024352.1_45724001_3 - 0.41 11.1 14.5 0.073 13.4 2.8 3.7 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger zf-CCCH PF00642.22 001024352.1_45724001_3 - 9.8 6.1 9.2 2.1 8.2 4.9 2.2 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Trypsin PF00089.24 001195725.1_37923001_1 - 2.3e-67 226.9 0.3 3.2e-67 226.5 0.3 1.2 1 0 0 1 1 1 1 Trypsin Gla PF00594.18 001195725.1_37923001_1 - 1.1e-20 73.4 11.1 2.5e-20 72.2 11.1 1.6 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FXa_inhibition PF14670.4 001195725.1_37923001_1 - 4.3e-09 36.4 7.6 4.3e-09 36.4 7.6 3.0 3 0 0 3 3 3 1 Coagulation Factor Xa inhibitory site EGF PF00008.25 001195725.1_37923001_1 - 1.8e-06 28.0 19.4 1.6e-05 24.9 7.5 2.9 2 0 0 2 2 2 2 EGF-like domain Trypsin_2 PF13365.4 001195725.1_37923001_1 - 1e-05 26.3 0.1 2.4e-05 25.1 0.1 1.7 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001195725.1_37923001_1 - 6.6e-05 23.1 0.0 0.00015 22.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) cEGF PF12662.5 001195725.1_37923001_1 - 0.0032 17.2 0.5 0.0032 17.2 0.5 3.7 4 0 0 4 4 4 1 Complement Clr-like EGF-like hEGF PF12661.5 001195725.1_37923001_1 - 1.5 9.5 15.5 0.31 11.7 5.1 3.8 2 1 0 2 2 2 0 Human growth factor-like EGF p450 PF00067.20 001190430.1_37924001_1 - 6.5e-103 344.8 0.0 7.8e-103 344.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PRP3 PF08572.8 001133309.1_43525001_2 - 1.4e-79 266.8 7.4 1.4e-79 266.8 7.4 2.7 3 1 0 3 3 3 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.10 001133309.1_43525001_2 - 1.3e-48 164.7 1.9 3.7e-48 163.2 1.9 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) PWI PF01480.15 001133309.1_43525001_2 - 1.6e-13 50.6 0.0 4e-13 49.3 0.0 1.7 1 0 0 1 1 1 1 PWI domain B PF02216.14 001133309.1_43525001_2 - 0.18 11.7 0.6 6.2 6.8 0.1 2.6 2 0 0 2 2 2 0 B domain Methyltransf_32 PF13679.4 001133309.1_43525001_2 - 6.1 6.7 7.2 14 5.5 3.9 3.0 2 1 0 2 2 2 0 Methyltransferase domain LRR_8 PF13855.4 001195691.1_37925001_2 - 1.6e-34 117.3 18.0 8e-14 51.0 1.6 4.5 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 001195691.1_37925001_2 - 1.3e-13 50.6 21.0 7.8e-05 22.8 0.8 5.8 2 2 5 7 7 7 7 Leucine Rich repeats (2 copies) LRRNT PF01462.16 001195691.1_37925001_2 - 1.3e-11 43.8 9.5 3e-10 39.4 3.2 4.1 3 0 0 3 3 3 2 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 001195691.1_37925001_2 - 3.2e-09 36.4 7.5 0.00032 20.1 0.8 3.3 1 1 2 3 3 3 2 Leucine-rich repeat LRR_5 PF13306.4 001195691.1_37925001_2 - 3.2e-05 23.8 0.0 0.00038 20.3 0.0 2.2 1 1 1 2 2 2 1 Leucine rich repeats (6 copies) LRR_1 PF00560.31 001195691.1_37925001_2 - 0.046 14.1 17.6 11 6.9 0.1 7.8 6 2 2 8 8 8 0 Leucine Rich Repeat IPP-2 PF04979.12 001082744.2_37925001_2 - 3.2e-41 141.0 9.8 3.2e-41 141.0 9.8 1.5 2 0 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) GTF2I PF02946.12 001081466.2_32927001_2 - 4e-187 606.6 12.0 1.3e-31 108.3 0.1 6.2 6 0 0 6 6 6 6 GTF2I-like repeat AAA_25 PF13481.4 001081466.2_32927001_2 - 0.039 13.4 0.0 9.3 5.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF4806 PF16064.3 001081466.2_32927001_2 - 0.044 14.0 0.0 36 4.6 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4806) LBP_BPI_CETP_C PF02886.15 001195719.1_37923001_1 - 2.4e-99 331.5 0.2 3.7e-99 330.9 0.2 1.3 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.23 001195719.1_37923001_1 - 6.2e-44 149.4 0.0 3.6e-43 146.9 0.0 2.0 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain Serpin PF00079.18 001185037.1_08023001_1 - 2.1e-60 204.8 0.0 3.2e-60 204.3 0.0 1.3 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) FIST PF08495.8 001185037.1_08023001_1 - 0.19 11.6 0.4 0.31 10.9 0.4 1.6 1 1 0 1 1 1 0 FIST N domain Ldh_1_N PF00056.21 001195707.1_37923001_1 - 4.2e-50 169.4 1.0 6.1e-50 168.9 1.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 001195707.1_37923001_1 - 1.2e-23 83.7 0.0 2.3e-23 82.8 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.14 001195707.1_37923001_1 - 0.0016 17.9 0.3 0.0047 16.4 0.0 1.9 2 0 0 2 2 2 1 Family 4 glycosyl hydrolase UQ_con PF00179.24 001271016.1_32924001_1 - 2.2e-10 40.2 0.0 3.5e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UQ_con PF00179.24 001271016.1_32924001_3 - 2.2e-05 24.0 0.1 3.3e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Caveolin PF01146.15 001242731.1_37626001_3 - 7.4e-59 197.3 0.9 1.2e-58 196.7 0.9 1.3 1 0 0 1 1 1 1 Caveolin Glyco_hydro_38 PF01074.20 001257246.1_09927001_2 - 8.5e-96 320.6 1.4 1.2e-95 320.1 1.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.11 001257246.1_09927001_2 - 1.2e-93 314.5 0.0 1.5e-93 314.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.9 001257246.1_09927001_2 - 3.8e-19 68.7 0.0 8.6e-19 67.6 0.0 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain DUF4304 PF14137.4 001257246.1_09927001_2 - 0.17 11.9 0.1 0.45 10.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4304) Myelin_MBP PF01669.15 001243070.1_39723001_1 - 3.7e-70 235.3 8.4 5.3e-70 234.8 8.4 1.2 1 0 0 1 1 1 1 Myelin basic protein Cornifin PF02389.13 214238.2_49822001_1 - 1.2e-26 93.4 50.7 1.2e-26 93.4 50.7 2.9 2 1 0 2 2 2 1 Cornifin (SPRR) family Branch PF02485.19 008105.3_32929001_1 - 4.8e-58 196.4 0.0 7.1e-58 195.9 0.0 1.3 1 0 0 1 1 1 1 Core-2/I-Branching enzyme Guanylate_kin PF00625.19 001101715.2_37926001_2 - 1.7e-45 154.8 0.4 2.5e-45 154.3 0.1 1.4 2 0 0 2 2 2 1 Guanylate kinase VGCC_beta4Aa_N PF12052.6 001101715.2_37926001_2 - 2.7e-19 68.9 7.1 7.2e-19 67.5 7.1 1.8 1 0 0 1 1 1 1 Voltage gated calcium channel subunit beta domain 4Aa N terminal Dynein_light PF01221.16 001244667.1_49823001_3 - 2.6e-26 91.6 0.7 3.5e-26 91.2 0.1 1.5 2 0 0 2 2 2 1 Dynein light chain type 1 DUF3109 PF11307.6 001244667.1_49823001_3 - 0.12 12.0 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3109) RF-1 PF00472.18 001194995.1_26224001_2 - 1.3e-21 76.5 1.2 2.2e-21 75.8 1.2 1.2 1 0 0 1 1 1 1 RF-1 domain Catalase PF00199.17 001267733.1_08025001_2 - 4.4e-196 651.3 0.0 5.8e-196 650.9 0.0 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.10 001267733.1_08025001_2 - 4.8e-18 65.0 1.3 1e-17 63.9 0.5 2.0 2 0 0 2 2 2 1 Catalase-related immune-responsive Ig_2 PF13895.4 001271655.1_29622001_1 - 4.1e-21 75.0 1.6 5.2e-11 42.6 0.3 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.4 001271655.1_29622001_1 - 1.5e-15 57.5 0.4 5.1e-08 33.3 0.2 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.23 001271655.1_29622001_1 - 1e-09 38.3 2.0 0.00092 19.2 0.1 2.8 2 1 0 2 2 2 2 Immunoglobulin domain Ig_4 PF16680.3 001271655.1_29622001_1 - 4.4e-07 30.0 1.1 0.012 15.9 0.0 2.6 3 0 0 3 3 3 2 T-cell surface glycoprotein CD3 delta chain I-set PF07679.14 001271655.1_29622001_1 - 1.8e-06 27.8 0.2 0.024 14.6 0.1 3.2 2 2 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.15 001271655.1_29622001_1 - 0.00014 21.8 6.8 0.19 11.8 0.1 4.2 3 2 0 3 3 3 2 Immunoglobulin V-set domain Ig_5 PF16681.3 001271655.1_29622001_1 - 0.012 15.9 7.0 0.017 15.4 0.0 2.9 4 0 0 4 4 4 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.3 001271655.1_29622001_1 - 0.11 12.5 0.1 3.8 7.5 0.0 2.9 2 1 1 3 3 3 0 Izumo-like Immunoglobulin domain Collagen PF01391.16 001195668.1_37929001_1 - 2.2e-163 530.0 673.0 7.1e-08 32.0 33.6 21.0 2 1 14 16 16 16 14 Collagen triple helix repeat (20 copies) COLFI PF01410.16 001195668.1_37929001_1 - 1.6e-106 354.7 0.3 2e-106 354.4 0.3 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain wnt PF00110.17 001242738.1_37625001_3 - 8.3e-122 406.4 24.7 1.1e-121 406.0 24.7 1.1 1 0 0 1 1 1 1 wnt family Carb_anhydrase PF00194.19 001195133.1_39722001_1 - 1.6e-95 319.4 0.2 1.8e-95 319.2 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase p450 PF00067.20 001204434.1_08024001_1 - 7.8e-101 338.0 0.0 9.6e-101 337.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 7tm_2 PF00002.22 001082375.2_37928001_1 - 3.2e-84 281.9 22.8 4.5e-84 281.5 22.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 001082375.2_37928001_1 - 1e-17 64.0 8.3 1e-17 64.0 8.3 1.8 2 0 0 2 2 2 1 Hormone receptor domain zf-H2C2_2 PF13465.4 175311.4_32925001_2 - 6.4e-44 146.4 83.4 5.8e-10 39.0 2.4 10.8 11 0 0 11 11 11 7 Zinc-finger double domain zf-H2C2_5 PF13909.4 175311.4_32925001_2 - 9.8e-36 121.0 59.0 9.9e-06 25.1 1.6 8.4 8 0 0 8 8 8 8 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 175311.4_32925001_2 - 2.4e-18 65.4 92.0 0.00035 20.7 4.6 10.0 10 0 0 10 10 10 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 175311.4_32925001_2 - 0.031 14.9 3.5 0.031 14.9 3.5 10.1 11 0 0 11 11 11 0 C2H2-type zinc finger GAGA PF09237.9 175311.4_32925001_2 - 2.5 7.8 26.9 0.12 12.1 0.8 5.5 2 2 2 5 5 5 0 GAGA factor DUF3505 PF12013.6 175311.4_32925001_2 - 8.2 6.8 48.9 0.94 9.8 0.6 8.2 4 2 4 8 8 8 0 Protein of unknown function (DUF3505) SlyX PF04102.10 001033208.4_32925001_1 - 0.017 15.6 5.4 0.017 15.6 5.4 5.6 2 2 2 5 5 5 0 SlyX Reo_sigmaC PF04582.10 001033208.4_32925001_1 - 1.4 8.1 10.6 3.9 6.6 2.1 2.3 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Spc7 PF08317.9 001033208.4_32925001_1 - 4.1 6.1 58.5 0.34 9.6 12.9 3.5 1 1 2 3 3 3 0 Spc7 kinetochore protein BLOC1_2 PF10046.7 001033208.4_32925001_1 - 4.5 7.5 41.3 0.62 10.3 0.8 4.9 1 1 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Filament PF00038.19 001033208.4_32925001_1 - 5.2 6.4 56.0 6.7 6.1 44.1 2.7 1 1 0 2 2 2 0 Intermediate filament protein Sod_Fe_C PF02777.16 214127.2_49824001_3 - 3.3e-38 129.8 0.0 5.5e-38 129.1 0.0 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.20 214127.2_49824001_3 - 9.5e-33 112.4 3.3 1.4e-32 111.9 3.3 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Peptidase_C2 PF00648.19 001195722.1_37926001_1 - 8.4e-127 422.1 0.0 1.2e-126 421.6 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.20 001195722.1_37926001_1 - 1.8e-53 180.5 0.0 2.8e-53 179.9 0.0 1.3 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_1 PF00036.30 001195722.1_37926001_1 - 1e-09 37.1 4.1 0.018 14.5 0.0 4.5 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.4 001195722.1_37926001_1 - 3.1e-09 35.9 2.2 0.056 13.3 0.0 4.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.4 001195722.1_37926001_1 - 1e-08 34.7 1.8 1e-06 28.3 0.2 3.0 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.4 001195722.1_37926001_1 - 8.9e-05 22.8 5.8 1.7 9.0 0.3 4.2 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.4 001195722.1_37926001_1 - 0.11 11.9 1.2 10 5.7 0.0 3.6 3 0 0 3 3 3 0 EF hand An_peroxidase PF03098.13 001184752.1_49825001_1 - 1.3e-121 406.7 0.0 2.4e-88 296.9 0.0 2.1 1 1 1 2 2 2 2 Animal haem peroxidase Sushi PF00084.18 001184752.1_49825001_1 - 4.8e-06 27.0 0.1 1.7e-05 25.2 0.1 2.0 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) EGF_CA PF07645.13 001184752.1_49825001_1 - 7.8e-06 25.9 5.9 7.8e-06 25.9 5.9 2.2 3 0 0 3 3 3 1 Calcium-binding EGF domain EGF_3 PF12947.5 001184752.1_49825001_1 - 0.00015 21.8 6.0 0.0004 20.4 6.0 1.8 1 0 0 1 1 1 1 EGF domain cEGF PF12662.5 001184752.1_49825001_1 - 0.079 12.8 3.9 2.6 7.9 0.1 3.0 2 0 0 2 2 2 0 Complement Clr-like EGF-like FXa_inhibition PF14670.4 001184752.1_49825001_1 - 0.085 13.0 12.1 0.032 14.4 7.3 2.7 3 0 0 3 3 3 0 Coagulation Factor Xa inhibitory site EGF PF00008.25 001184752.1_49825001_1 - 0.14 12.3 4.4 0.29 11.4 3.0 2.4 1 1 0 1 1 1 0 EGF-like domain VWA_3 PF13768.4 001198653.1_45729001_1 - 1.9e-64 216.1 0.1 3.8e-26 91.7 0.0 3.5 3 0 0 3 3 3 3 von Willebrand factor type A domain VWA_2 PF13519.4 001198653.1_45729001_1 - 8.4e-13 48.8 0.0 0.00026 21.5 0.0 3.8 3 0 0 3 3 3 3 von Willebrand factor type A domain VWA PF00092.26 001198653.1_45729001_1 - 3e-12 47.0 0.0 9.5e-09 35.6 0.0 3.0 3 0 0 3 3 3 2 von Willebrand factor type A domain SCP2 PF02036.15 004809.4_26225001_3 - 1.7e-16 60.4 0.0 7.5e-16 58.3 0.0 2.0 2 0 0 2 2 2 1 SCP-2 sterol transfer family Band_7 PF01145.23 004809.4_26225001_3 - 1.7e-15 57.4 0.0 4e-15 56.1 0.0 1.6 2 0 0 2 2 2 1 SPFH domain / Band 7 family DHQS PF01959.14 004809.4_26225001_3 - 0.24 10.1 0.0 0.33 9.6 0.0 1.1 1 0 0 1 1 1 0 3-dehydroquinate synthase (EC 4.6.1.3) ADH_N PF08240.10 001184829.1_37924001_1 - 3.9e-21 74.8 0.2 8.5e-21 73.8 0.2 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.24 001184829.1_37924001_1 - 1e-20 73.8 0.5 1.9e-20 72.9 0.5 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.4 001184829.1_37924001_1 - 0.00058 20.8 0.0 0.0016 19.4 0.0 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.12 001184829.1_37924001_1 - 0.023 14.2 0.1 0.043 13.3 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Peptidase_C1 PF00112.21 213929.2_49823001_2 - 2e-80 269.9 1.2 2.7e-80 269.4 1.2 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 213929.2_49823001_2 - 4.3e-18 65.3 3.7 7.4e-18 64.6 3.7 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 213929.2_49823001_2 - 2.7e-05 23.0 0.6 0.012 14.3 0.0 2.2 2 0 0 2 2 2 2 Peptidase C1-like family Pro-kuma_activ PF09286.9 001131147.1_43527001_1 - 1.1e-31 110.0 0.0 1.8e-31 109.2 0.0 1.4 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.20 001131147.1_43527001_1 - 0.0015 17.8 0.1 0.0022 17.2 0.1 1.2 1 0 0 1 1 1 1 Subtilase family Ribosomal_L5e PF17144.2 001195679.1_37923001_2 - 9.9e-95 314.8 0.7 9.9e-95 314.8 0.7 2.1 2 0 0 2 2 2 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.4 001195679.1_37923001_2 - 5.4e-40 136.1 12.1 5.4e-40 136.1 12.1 1.7 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Ig_3 PF13927.4 001267769.1_08024001_3 - 1.1e-05 25.9 0.0 0.29 11.6 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.15 001267769.1_08024001_3 - 1.1e-05 25.4 0.0 0.53 10.3 0.0 3.9 3 1 0 3 3 3 2 Immunoglobulin V-set domain ig PF00047.23 001267769.1_08024001_3 - 3.6e-05 23.7 0.1 0.26 11.4 0.0 3.9 3 1 0 3 3 3 2 Immunoglobulin domain I-set PF07679.14 001267769.1_08024001_3 - 0.024 14.6 0.0 6.5 6.8 0.0 2.7 2 1 0 2 2 2 0 Immunoglobulin I-set domain p450 PF00067.20 001267762.1_08024001_1 - 1e-99 334.3 0.4 1.3e-99 333.9 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF268 PF03269.12 001267762.1_08024001_1 - 0.064 13.0 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 Caenorhabditis protein of unknown function, DUF268 RRM_1 PF00076.20 001197111.1_39724001_1 - 6.2e-36 121.9 0.1 2.1e-17 62.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 PF11627.6 001197111.1_39724001_1 - 6.8e-20 70.7 25.8 6.8e-20 70.7 25.8 5.8 2 1 3 5 5 5 1 Nuclear factor hnRNPA1 RRM_7 PF16367.3 001197111.1_39724001_1 - 4e-11 42.8 0.1 4.5e-06 26.6 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.4 001197111.1_39724001_1 - 0.00017 21.4 0.2 0.091 12.6 0.1 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif WD40 PF00400.30 001195718.1_37924001_3 - 1.3e-09 38.3 3.0 1.5 9.7 0.1 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001195718.1_37924001_3 - 0.00023 21.2 0.1 2.3 8.5 0.0 4.3 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Androgen_recep PF02166.14 001195724.1_37926001_1 - 5.7e-239 793.7 39.9 7.2e-239 793.4 39.9 1.1 1 0 0 1 1 1 1 Androgen receptor Hormone_recep PF00104.28 001195724.1_37926001_1 - 5.1e-31 107.7 2.9 5.1e-31 107.7 2.9 1.7 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001195724.1_37926001_1 - 3.9e-27 94.4 14.4 8.8e-27 93.2 14.4 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) RP-C_C PF11800.6 001195724.1_37926001_1 - 1.7 8.5 8.8 0.91 9.4 4.9 2.1 2 0 0 2 2 2 0 Replication protein C C-terminal region Trypan_PARP PF05887.9 001195724.1_37926001_1 - 2 8.3 8.1 4.4 7.2 8.1 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) PIH1 PF08190.10 001195724.1_37926001_1 - 2.7 7.6 10.1 5.9 6.5 10.1 1.5 1 0 0 1 1 1 0 pre-RNA processing PIH1/Nop17 DUF2722 PF10846.6 001195724.1_37926001_1 - 4.1 6.1 22.4 0.052 12.3 13.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Spt20 PF12090.6 001195724.1_37926001_1 - 4.6 6.6 32.4 0.61 9.5 24.1 2.3 2 0 0 2 2 2 0 Spt20 family Tim54 PF11711.6 001195724.1_37926001_1 - 5.8 5.4 7.7 12 4.5 7.7 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 TCP PF03634.11 001195724.1_37926001_1 - 8.5 6.8 11.6 21 5.5 4.1 3.2 3 0 0 3 3 3 0 TCP family transcription factor CortBP2 PF09727.7 001242735.1_37629001_3 - 5.2e-38 130.7 31.8 9.5e-33 113.6 1.2 3.4 2 1 1 3 3 3 2 Cortactin-binding protein-2 Ank_2 PF12796.5 001242735.1_37629001_3 - 7e-37 125.7 9.3 6.3e-18 65.0 4.4 3.5 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001242735.1_37629001_3 - 6.8e-33 112.5 10.7 1.4e-10 41.3 0.5 5.0 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.4 001242735.1_37629001_3 - 1.6e-21 75.9 15.0 1.3e-08 34.8 0.1 5.9 3 1 3 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.28 001242735.1_37629001_3 - 1.2e-18 66.5 13.1 0.00026 21.2 0.0 6.9 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.4 001242735.1_37629001_3 - 3e-18 63.9 4.7 0.0012 19.0 0.0 7.0 6 0 0 6 6 6 4 Ankyrin repeat DUF812 PF05667.9 001242735.1_37629001_3 - 0.18 10.5 22.0 0.29 9.8 22.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Rota_NSP3 PF01665.14 001242735.1_37629001_3 - 0.79 8.7 4.6 1.4 7.8 4.6 1.4 1 0 0 1 1 1 0 Rotavirus non-structural protein NSP3 Exonuc_VII_L PF02601.13 001242735.1_37629001_3 - 3.8 6.9 13.0 8.7 5.7 13.0 1.6 1 0 0 1 1 1 0 Exonuclease VII, large subunit Connexin PF00029.17 001244212.1_49827001_2 - 2.7e-92 308.5 3.7 4.6e-92 307.7 3.7 1.4 1 0 0 1 1 1 1 Connexin Connexin43 PF03508.11 001244212.1_49827001_2 - 1.5e-10 40.3 15.4 2.8e-10 39.4 15.4 1.5 1 0 0 1 1 1 1 Gap junction alpha-1 protein (Cx43) Connexin40_C PF16791.3 001244212.1_49827001_2 - 0.00024 22.2 1.9 0.00039 21.5 1.9 1.3 1 0 0 1 1 1 1 Connexin 40 C-terminal domain Dynein_light PF01221.16 001244668.1_49823001_2 - 2.5e-26 91.7 0.7 3.4e-26 91.2 0.1 1.5 2 0 0 2 2 2 1 Dynein light chain type 1 DUF3109 PF11307.6 001244668.1_49823001_2 - 0.12 12.1 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3109) Sod_Fe_C PF02777.16 001267746.1_08022001_1 - 5.2e-39 132.4 0.1 1.1e-38 131.4 0.0 1.5 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.20 001267746.1_08022001_1 - 2.1e-33 114.5 3.2 3.2e-33 113.9 3.2 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain LRR_8 PF13855.4 001195680.1_37924001_2 - 1.4e-32 111.1 34.6 7.4e-11 41.5 2.8 6.7 3 2 3 7 7 7 6 Leucine rich repeat LRR_4 PF12799.5 001195680.1_37924001_2 - 5.4e-23 80.5 31.0 1.8e-06 28.0 0.1 6.5 2 1 7 9 9 9 8 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 001195680.1_37924001_2 - 5.7e-09 35.2 22.6 1.6 8.9 0.1 9.1 9 0 0 9 9 9 4 Leucine Rich repeat LRRNT PF01462.16 001195680.1_37924001_2 - 9.7e-09 34.6 2.9 2.6e-08 33.2 2.9 1.8 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.4 001195680.1_37924001_2 - 9.2e-08 31.6 7.7 0.0048 16.3 1.0 3.3 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.31 001195680.1_37924001_2 - 2.4e-07 30.1 22.7 4.7 8.0 0.3 9.4 7 3 1 8 8 8 1 Leucine Rich Repeat LRR_5 PF13306.4 001195680.1_37924001_2 - 6.9e-06 25.9 3.3 0.0026 17.6 0.2 3.3 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) HTH_Tnp_1 PF01527.18 001195113.1_49827001_1 - 4.3e-09 36.4 4.4 9e-05 22.6 0.1 4.6 5 0 0 5 5 5 2 Transposase HTH_23 PF13384.4 001195113.1_49827001_1 - 1.2e-07 31.2 2.2 0.036 13.7 0.1 4.6 4 0 0 4 4 4 2 Homeodomain-like domain HTH_Tnp_1_2 PF13022.4 001195113.1_49827001_1 - 0.0002 21.4 4.8 0.69 9.9 0.1 4.3 5 0 0 5 5 5 2 Helix-turn-helix of insertion element transposase DUF1492 PF07374.9 001195113.1_49827001_1 - 0.0025 17.8 1.4 11 6.1 0.0 4.3 5 0 0 5 5 5 1 Protein of unknown function (DUF1492) HTH_36 PF13730.4 001195113.1_49827001_1 - 0.004 17.0 0.0 0.87 9.5 0.0 3.7 3 0 0 3 3 3 1 Helix-turn-helix domain DAZAP2 PF11029.6 001195113.1_49827001_1 - 0.039 14.8 0.1 0.11 13.3 0.1 1.7 1 0 0 1 1 1 0 DAZ associated protein 2 (DAZAP2) HTH_29 PF13551.4 001195113.1_49827001_1 - 0.047 13.6 0.9 0.97 9.4 0.0 3.1 3 0 0 3 3 3 0 Winged helix-turn helix HTH_28 PF13518.4 001195113.1_49827001_1 - 0.11 12.6 10.8 1.5 8.9 0.1 4.6 5 0 0 5 5 5 0 Helix-turn-helix domain HTH_17 PF12728.5 001195113.1_49827001_1 - 0.13 12.3 4.3 13 5.9 0.1 3.9 4 0 0 4 4 4 0 Helix-turn-helix domain Serpin PF00079.18 026535.2_32928001_1 - 1e-110 370.4 2.8 1.3e-110 370.1 2.8 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) MCM PF00493.21 173518.4_26229001_1 - 1.2e-12 47.4 0.0 1.9e-06 27.0 0.0 2.1 2 0 0 2 2 2 2 MCM2/3/5 family Mg_chelatase PF01078.19 173518.4_26229001_1 - 0.12 11.6 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NTP_transf_7 PF07984.10 001014041.1_45725001_2 - 1.2e-158 527.3 0.3 1.4e-158 527.1 0.3 1.0 1 0 0 1 1 1 1 Nucleotidyltransferase Tankyrase_bdg_C PF15327.4 172884.3_32929001_2 - 2e-59 200.7 15.6 2e-59 200.7 15.6 1.6 2 0 0 2 2 2 1 Tankyrase binding protein C terminal domain CN_hydrolase PF00795.20 001305647.1_45723001_1 - 1e-71 241.2 0.0 1.2e-71 241.0 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DUF3136 PF11334.6 001305647.1_45723001_2 - 0.13 12.0 1.3 0.29 10.8 1.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3136) PseudoU_synth_2 PF00849.20 001025284.1_45724001_2 - 2.3e-33 115.5 0.0 3.9e-33 114.7 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase Lectin_C PF00059.19 001281555.1_31322001_3 - 3.2e-19 69.5 0.3 4.7e-19 69.0 0.3 1.3 1 0 0 1 1 1 1 Lectin C-type domain DUF2272 PF10030.7 001281555.1_31322001_3 - 0.028 13.7 0.0 0.04 13.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2272) PT PF04886.10 001356605.1_32923001_1 - 0.18 11.3 9.8 0.63 9.5 9.8 2.0 1 1 0 1 1 1 0 PT repeat S_100 PF01023.17 001356605.1_32923001_2 - 1.3e-09 37.4 0.3 2.1e-09 36.8 0.3 1.3 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_5 PF13202.4 001356605.1_32923001_2 - 0.00044 19.5 0.0 0.00099 18.4 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.4 001356605.1_32923001_2 - 0.00045 20.5 0.0 0.00094 19.5 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.4 001356605.1_32923001_2 - 0.0023 17.6 0.1 0.004 16.8 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 001356605.1_32923001_2 - 0.0047 16.3 0.1 0.024 14.1 0.0 2.0 2 0 0 2 2 2 1 EF hand Herpes_UL56 PF04534.10 001356605.1_32923001_3 - 4.7e-05 22.8 2.1 4.7e-05 22.8 2.1 2.0 3 0 0 3 3 3 1 Herpesvirus UL56 protein CITED PF04487.10 001266177.2_29622001_3 - 6.2e-31 108.0 0.2 1.2e-30 107.0 0.0 1.4 1 1 0 1 1 1 1 CITED EHN PF06441.10 001082275.1_37924001_1 - 5.3e-34 116.6 0.3 9.2e-34 115.8 0.3 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.18 001082275.1_37924001_1 - 9.1e-28 97.5 0.0 1.3e-27 96.9 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001082275.1_37924001_1 - 0.0045 17.5 0.0 0.046 14.2 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Cys_knot PF00007.20 001098553.1_39725001_3 - 5.5e-16 58.6 10.9 5.5e-16 58.6 10.9 3.0 3 1 0 3 3 3 1 Cystine-knot domain IGFBP PF00219.16 001098553.1_39725001_3 - 4.8e-10 39.8 24.1 4.8e-10 39.8 24.1 6.0 4 2 0 4 4 4 1 Insulin-like growth factor binding protein VWC PF00093.16 001098553.1_39725001_3 - 1.3e-09 38.1 12.7 1.3e-09 38.1 12.7 5.3 4 3 0 4 4 4 1 von Willebrand factor type C domain TSP_1 PF00090.17 001098553.1_39725001_3 - 0.00052 20.0 8.4 0.00052 20.0 8.4 3.7 4 0 0 4 4 4 1 Thrombospondin type 1 domain Trypsin PF00089.24 001133379.1_43525001_2 - 1e-67 228.1 0.0 1.6e-67 227.5 0.0 1.3 1 0 0 1 1 1 1 Trypsin Kringle PF00051.16 001133379.1_43525001_2 - 6.6e-49 164.0 11.5 2.7e-25 88.4 3.3 2.5 2 0 0 2 2 2 2 Kringle domain Thrombin_light PF09396.8 001133379.1_43525001_2 - 1.1e-26 92.2 1.1 1.9e-26 91.4 1.1 1.4 1 0 0 1 1 1 1 Thrombin light chain Gla PF00594.18 001133379.1_43525001_2 - 2.5e-18 65.9 5.1 5.3e-18 64.8 5.1 1.6 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain DUF1986 PF09342.9 001133379.1_43525001_2 - 0.0019 18.5 0.0 0.0036 17.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 001133379.1_43525001_2 - 0.019 15.7 0.0 0.047 14.4 0.0 1.7 1 1 0 1 1 1 0 Trypsin-like peptidase domain SRCR PF00530.16 001082248.1_37924001_2 - 4.3e-31 107.2 3.4 8.2e-31 106.3 3.4 1.5 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Macscav_rec PF03523.11 001082248.1_37924001_2 - 6.1e-30 102.7 0.9 1.1e-29 101.9 0.9 1.5 1 0 0 1 1 1 1 Macrophage scavenger receptor Collagen PF01391.16 001082248.1_37924001_2 - 2.2e-13 49.6 55.8 3.5e-08 33.0 24.6 2.3 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) SRCR_2 PF15494.4 001082248.1_37924001_2 - 8.2e-06 26.1 2.1 8.6e-06 26.1 0.2 1.9 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain HAUS6_N PF14661.4 001082248.1_37924001_2 - 0.0061 16.1 3.9 0.02 14.4 4.1 1.7 1 1 0 1 1 1 1 HAUS augmin-like complex subunit 6 N-terminus Reo_sigmaC PF04582.10 001082248.1_37924001_2 - 0.048 12.9 1.7 0.069 12.4 1.7 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF16 PF01519.14 001082248.1_37924001_2 - 0.56 10.6 9.3 7.1 7.0 9.1 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 Snapin_Pallidin PF14712.4 001082248.1_37924001_2 - 5.5 7.4 7.3 4.8 7.6 0.9 2.7 2 1 1 3 3 3 0 Snapin/Pallidin CC2-LZ PF16516.3 001082248.1_37924001_2 - 6.8 6.9 8.4 0.88 9.8 4.1 1.7 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Tubulin PF00091.23 001034095.1_39724001_3 - 6.9e-69 231.9 0.0 9.2e-69 231.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 001034095.1_39724001_3 - 2.3e-51 173.1 0.0 3.5e-51 172.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 001034095.1_39724001_3 - 0.0017 17.9 0.0 0.0032 17.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Lipocalin_7 PF14651.4 001004046.2_49821001_1 - 1.9e-28 98.8 4.0 2.2e-28 98.6 4.0 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin PF00061.21 001004046.2_49821001_1 - 1.4e-14 54.4 2.7 1.6e-14 54.2 2.7 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family 7tm_1 PF00001.19 001009789.2_39523001_3 - 9.6e-17 60.9 12.5 1.4e-16 60.4 12.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 001009789.2_39523001_3 - 1.5e-06 27.7 15.4 1.9e-06 27.3 15.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Serpentine_r_xa PF03383.13 001009789.2_39523001_3 - 7.5e-05 22.6 1.6 7.5e-05 22.6 1.6 2.4 2 1 1 3 3 3 1 Caenorhabditis serpentine receptor-like protein, class xa Ion_trans PF00520.29 001082036.1_37924001_1 - 3e-52 177.1 0.5 4e-52 176.8 0.5 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.20 001082036.1_37924001_1 - 8.1e-27 93.3 0.0 1.4e-26 92.5 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 001082036.1_37924001_1 - 1.2e-13 50.6 5.8 1.2e-13 50.6 5.8 2.4 3 0 0 3 3 3 1 Ion channel PKD_channel PF08016.10 001082036.1_37924001_1 - 0.00055 18.6 2.0 0.00095 17.8 2.0 1.3 1 0 0 1 1 1 1 Polycystin cation channel DctQ PF04290.10 001082036.1_37924001_1 - 0.087 12.6 1.6 0.18 11.6 0.6 2.0 2 0 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component Prot_inhib_II PF02428.13 001163180.1_37922001_2 - 0.0075 16.6 3.8 0.014 15.7 3.8 1.4 1 0 0 1 1 1 1 Potato type II proteinase inhibitor family IL2 PF00715.15 001163180.1_37922001_3 - 3.6e-74 247.4 4.5 4.7e-74 247.0 4.5 1.1 1 0 0 1 1 1 1 Interleukin 2 7tm_1 PF00001.19 001082648.1_37922001_1 - 7.1e-13 48.3 0.0 1.1e-12 47.7 0.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LPG_synthase_TM PF03706.11 001082648.1_37922001_1 - 1.3 8.3 29.4 0.28 10.6 13.5 2.6 1 1 1 2 2 2 0 Lysylphosphatidylglycerol synthase TM region IL13 PF03487.11 001008992.1_39721001_1 - 5.7e-69 229.8 0.0 6.3e-69 229.7 0.0 1.0 1 0 0 1 1 1 1 Interleukin-13 HLH PF00010.24 001009050.2_39723001_1 - 4.2e-17 61.7 0.3 8.9e-17 60.7 0.3 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF773 PF05600.10 001009050.2_39723001_1 - 0.059 12.0 0.3 0.079 11.6 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF773) TAS2R PF05296.11 001080766.1_29622001_1 - 5.7e-121 403.1 29.0 6.5e-121 403.0 29.0 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) 7tm_1 PF00001.19 001080766.1_29622001_1 - 0.044 12.9 19.4 0.059 12.5 19.4 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Death PF00531.20 213839.1_49826001_1 - 2.6e-17 62.6 0.0 4.1e-17 62.0 0.0 1.3 1 0 0 1 1 1 1 Death domain TNFR_c6 PF00020.16 213839.1_49826001_1 - 8.5e-15 54.8 59.1 2.6e-09 37.2 12.1 3.8 3 0 0 3 3 3 3 TNFR/NGFR cysteine-rich region zf-H2C2_2 PF13465.4 001135633.1_39723001_2 - 4e-42 140.7 70.4 4.2e-08 33.2 3.3 9.4 9 1 1 10 10 9 8 Zinc-finger double domain zf-C2H2 PF00096.24 001135633.1_39723001_2 - 4.6e-26 89.7 62.6 1.6e-05 25.0 1.3 8.2 8 0 0 8 8 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001135633.1_39723001_2 - 7.9e-13 47.9 62.5 0.0054 17.3 0.9 8.1 8 0 0 8 8 7 6 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001135633.1_39723001_2 - 5.7e-11 42.0 44.7 0.0003 20.5 2.0 7.9 7 0 0 7 7 7 5 C2H2-type zinc finger zf-C2H2_11 PF16622.3 001135633.1_39723001_2 - 5.3e-07 29.2 29.8 0.15 11.7 0.7 7.3 7 0 0 7 7 7 4 zinc-finger C2H2-type zf-trcl PF13451.4 001135633.1_39723001_2 - 0.017 14.8 26.5 6.5 6.6 0.6 6.4 6 0 0 6 6 6 0 Probable zinc-ribbon domain XPA_N PF01286.16 001135633.1_39723001_2 - 0.024 14.6 31.1 1.2 9.1 0.2 7.2 7 0 0 7 7 7 0 XPA protein N-terminal Zn_Tnp_IS1595 PF12760.5 001135633.1_39723001_2 - 0.025 14.4 1.9 0.025 14.4 1.9 4.5 4 0 0 4 4 4 0 Transposase zinc-ribbon domain zf-C2H2_jaz PF12171.6 001135633.1_39723001_2 - 0.027 14.6 36.9 0.82 9.9 0.8 7.3 8 0 0 8 8 7 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 001135633.1_39723001_2 - 0.033 14.8 26.7 0.18 12.5 2.8 4.5 1 1 3 4 4 4 0 zinc-ribbon family Zn-ribbon_8 PF09723.8 001135633.1_39723001_2 - 0.035 14.1 38.8 0.58 10.2 0.2 6.0 3 2 3 6 6 6 0 Zinc ribbon domain zf-H2C2_5 PF13909.4 001135633.1_39723001_2 - 0.08 12.6 0.1 0.08 12.6 0.1 7.8 8 1 0 8 8 7 0 C2H2-type zinc-finger domain COX5B PF01215.17 001135633.1_39723001_2 - 4.7 6.8 15.5 1.4 8.5 0.2 4.5 2 1 3 5 5 5 0 Cytochrome c oxidase subunit Vb CpXC PF14353.4 001135633.1_39723001_2 - 8.7 6.3 20.0 47 3.9 1.0 5.4 2 1 1 4 4 4 0 CpXC protein IL12p40_C PF10420.7 001009438.1_39522001_1 - 4.1e-22 78.3 4.6 5.3e-22 78.0 0.7 2.4 2 0 0 2 2 2 1 Cytokine interleukin-12p40 C-terminus Ig_5 PF16681.3 001009438.1_39522001_1 - 1.2e-06 28.7 2.1 1.4e-05 25.3 0.1 2.7 2 1 1 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_3 PF13927.4 001009438.1_39522001_1 - 7.9e-06 26.3 4.9 2.3e-05 24.8 0.2 3.0 3 0 0 3 3 3 1 Immunoglobulin domain fn3 PF00041.19 001009438.1_39522001_1 - 1.4e-05 25.3 0.3 0.00029 21.0 0.3 2.8 2 0 0 2 2 2 1 Fibronectin type III domain Ig_4 PF16680.3 001009438.1_39522001_1 - 1.7e-05 24.9 2.2 0.00029 21.0 0.0 2.9 2 1 1 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Ig_2 PF13895.4 001009438.1_39522001_1 - 8.3e-05 22.7 0.3 0.0025 18.0 0.0 2.8 1 1 1 2 2 2 1 Immunoglobulin domain I-set PF07679.14 001009438.1_39522001_1 - 0.063 13.2 4.2 0.23 11.4 0.2 3.7 4 2 0 4 4 4 0 Immunoglobulin I-set domain V-set PF07686.15 001009438.1_39522001_1 - 0.086 12.9 3.3 25 4.9 0.0 3.7 3 1 0 4 4 4 0 Immunoglobulin V-set domain DUF3371 PF11851.6 001081483.1_39723001_1 - 1.4e-31 110.1 2.9 3.8e-31 108.6 2.9 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3371) HLH PF00010.24 001081483.1_39723001_1 - 5.5e-16 58.1 0.3 1.2e-15 57.0 0.3 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain RNA_pol_Rpc4 PF05132.12 001132172.1_43527001_1 - 9.1e-05 22.8 6.3 0.00014 22.2 6.3 1.2 1 0 0 1 1 1 1 RNA polymerase III RPC4 Ras PF00071.20 001132172.1_43527001_2 - 1.6e-57 193.5 0.5 2.4e-57 192.9 0.5 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001132172.1_43527001_2 - 1.5e-34 118.7 0.2 1.5e-34 118.7 0.2 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001132172.1_43527001_2 - 4.1e-14 52.3 0.2 7e-14 51.5 0.2 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.25 001132172.1_43527001_2 - 0.00018 21.0 0.1 0.00018 21.0 0.1 1.9 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.21 001132172.1_43527001_2 - 0.00042 20.2 0.1 0.0012 18.8 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001132172.1_43527001_2 - 0.0079 16.0 0.2 0.87 9.3 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 FeoB_N PF02421.16 001132172.1_43527001_2 - 0.014 14.8 0.2 0.083 12.3 0.2 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B RNA_pol_Rpc4 PF05132.12 001132172.1_43527001_3 - 0.22 11.8 13.9 0.34 11.2 13.9 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 EOS1 PF12326.6 001132172.1_43527001_3 - 0.6 9.9 5.5 0.97 9.2 5.5 1.3 1 0 0 1 1 1 0 N-glycosylation protein Connexin PF00029.17 001132172.1_43527001_3 - 2.8 7.5 15.3 4.6 6.8 15.3 1.3 1 0 0 1 1 1 0 Connexin TFR_dimer PF04253.13 214384.1_49826001_3 - 7.8e-32 109.8 0.0 1.3e-31 109.1 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.15 214384.1_49826001_3 - 4.2e-17 62.3 0.0 1.1e-16 61.0 0.0 1.7 2 0 0 2 2 2 1 Peptidase family M28 PA PF02225.20 214384.1_49826001_3 - 6.5e-13 48.5 0.0 1.7e-12 47.1 0.0 1.7 1 0 0 1 1 1 1 PA domain C2 PF00168.28 138835.1_45725001_2 - 4.3e-24 84.6 0.0 1.8e-15 56.9 0.1 2.5 2 0 0 2 2 2 2 C2 domain CFTR_R PF14396.4 001009781.1_39529001_1 - 4.4e-96 320.4 0.6 8.4e-96 319.4 0.6 1.5 1 0 0 1 1 1 1 Cystic fibrosis TM conductance regulator (CFTR), regulator domain ABC_membrane PF00664.21 001009781.1_39529001_1 - 1.2e-89 300.5 50.3 1.7e-47 162.3 24.8 3.3 2 1 1 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.25 001009781.1_39529001_1 - 3.2e-58 196.0 0.0 2.1e-32 112.4 0.0 2.8 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 001009781.1_39529001_1 - 4.7e-07 29.3 0.0 0.003 16.9 0.0 3.2 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.4 001009781.1_39529001_1 - 6.3e-07 29.3 1.8 0.067 12.9 0.2 3.4 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 001009781.1_39529001_1 - 1e-05 25.0 0.8 0.0038 16.8 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain T2SSE PF00437.18 001009781.1_39529001_1 - 1.6e-05 23.9 0.1 0.099 11.6 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein DUF258 PF03193.14 001009781.1_39529001_1 - 3.5e-05 23.7 1.2 0.015 15.1 0.1 2.7 2 1 0 2 2 2 1 Protein of unknown function, DUF258 AAA_16 PF13191.4 001009781.1_39529001_1 - 0.00019 21.7 0.4 0.85 9.8 0.0 2.9 3 0 0 3 3 2 2 AAA ATPase domain DUF87 PF01935.15 001009781.1_39529001_1 - 0.00052 20.0 1.0 0.23 11.3 0.1 2.8 2 0 0 2 2 2 1 Domain of unknown function DUF87 Zeta_toxin PF06414.10 001009781.1_39529001_1 - 0.0027 16.9 0.6 0.16 11.1 0.1 2.5 2 0 0 2 2 2 1 Zeta toxin MMR_HSR1 PF01926.21 001009781.1_39529001_1 - 0.0031 17.4 0.0 1 9.3 0.0 3.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase ArgK PF03308.14 001009781.1_39529001_1 - 0.0045 15.9 0.6 0.097 11.5 0.1 2.4 2 0 0 2 2 2 1 ArgK protein AAA_22 PF13401.4 001009781.1_39529001_1 - 0.0048 17.1 0.3 6.4 6.9 0.0 3.1 2 0 0 2 2 2 1 AAA domain Roc PF08477.11 001009781.1_39529001_1 - 0.0058 16.7 0.1 6.1 7.0 0.0 3.6 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase NTPase_1 PF03266.13 001009781.1_39529001_1 - 0.0088 15.8 0.5 0.4 10.5 0.0 2.8 3 0 0 3 3 3 1 NTPase NACHT PF05729.10 001009781.1_39529001_1 - 0.0098 15.7 3.1 1.7 8.4 0.0 3.1 3 0 0 3 3 3 1 NACHT domain TsaE PF02367.15 001009781.1_39529001_1 - 0.048 13.5 0.1 8.2 6.3 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.4 001009781.1_39529001_1 - 0.058 13.6 0.1 15 5.8 0.0 3.1 2 1 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.16 001009781.1_39529001_1 - 0.074 12.3 0.4 11 5.1 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family cobW PF02492.17 001009781.1_39529001_1 - 0.085 12.3 1.9 4.6 6.7 0.1 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.4 001009781.1_39529001_1 - 0.087 12.4 0.0 4.5 6.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.7 001009781.1_39529001_1 - 0.091 11.5 0.5 3.7 6.2 0.0 2.5 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_25 PF13481.4 001009781.1_39529001_1 - 0.15 11.5 0.7 9.4 5.6 0.1 2.3 2 0 0 2 2 2 0 AAA domain MobB PF03205.12 001009781.1_39529001_1 - 0.18 11.6 3.1 12 5.7 0.1 3.4 4 0 0 4 4 4 0 Molybdopterin guanine dinucleotide synthesis protein B fn3 PF00041.19 214097.2_49826001_3 - 3e-26 91.4 6.3 1.2e-08 35.0 0.0 5.6 5 1 0 5 5 5 4 Fibronectin type III domain Lep_receptor_Ig PF06328.9 214097.2_49826001_3 - 2.5e-12 46.5 0.5 7.1e-12 45.1 0.5 1.8 1 0 0 1 1 1 1 Ig-like C2-type domain IL6Ra-bind PF09240.8 214097.2_49826001_3 - 0.00069 19.9 0.1 0.0032 17.7 0.1 2.2 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding Pur_ac_phosph_N PF16656.3 214097.2_49826001_3 - 0.0054 17.1 0.1 0.62 10.5 0.0 2.9 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Defensin_beta_2 PF13841.4 001079927.1_39722001_1 - 4.5e-05 23.7 13.0 6.3e-05 23.2 13.0 1.2 1 0 0 1 1 1 1 Beta defensin CAP_N PF01213.17 001079927.1_39722001_1 - 5 6.4 8.7 3.5 6.9 5.9 1.8 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Topoisom_I_N PF02919.13 001112797.1_39724001_2 - 3.2e-98 327.3 0.6 3.2e-98 327.3 0.6 2.1 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.18 001112797.1_39724001_2 - 1.2e-97 325.5 1.4 1.2e-97 325.5 1.4 1.7 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.4 001112797.1_39724001_2 - 5.6e-32 109.3 0.1 1.4e-31 108.1 0.1 1.7 1 0 0 1 1 1 1 C-terminal topoisomerase domain DUF4407 PF14362.4 001112797.1_39724001_2 - 0.53 9.4 14.3 0.044 13.0 9.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Med9 PF07544.11 001112797.1_39724001_2 - 0.9 9.5 8.0 1.5 8.8 5.4 2.4 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF349 PF03993.10 001112797.1_39724001_2 - 3.6 7.8 13.8 2 8.7 6.1 3.1 2 1 0 2 2 2 0 Domain of Unknown Function (DUF349) FUSC PF04632.10 001112797.1_39724001_2 - 4.2 5.7 6.0 7 4.9 6.0 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Hrs_helical PF12210.6 001112797.1_39724001_2 - 4.3 7.8 10.3 8.1 6.9 2.9 3.6 2 1 1 3 3 3 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Exonuc_VII_L PF02601.13 001112797.1_39724001_2 - 4.7 6.6 11.9 2.2 7.6 9.3 1.7 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF641 PF04859.10 001112797.1_39724001_2 - 9.3 6.5 14.2 0.061 13.5 3.3 2.8 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) Ank_3 PF13606.4 001047144.1_29623001_1 - 5.4e-06 26.2 0.7 0.3 11.6 0.3 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.4 001047144.1_29623001_1 - 1.1e-05 25.7 0.7 5.1e-05 23.6 0.6 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.4 001047144.1_29623001_1 - 3.7e-05 23.8 7.0 0.00032 20.8 2.4 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 001047144.1_29623001_1 - 4.9e-05 23.7 0.0 9.5e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.28 001047144.1_29623001_1 - 0.0025 18.1 3.8 1.5 9.3 1.1 2.6 2 0 0 2 2 2 2 Ankyrin repeat PHD20L1_u1 PF16660.3 001047144.1_29623001_1 - 0.054 14.1 1.8 0.06 13.9 0.2 1.8 2 0 0 2 2 2 0 PHD finger protein 20-like protein 1 Glypican PF01153.17 001135737.1_39725001_3 - 2e-184 614.4 0.0 2.4e-184 614.1 0.0 1.0 1 0 0 1 1 1 1 Glypican RAWUL PF16207.3 001133961.1_43527001_1 - 5.1e-28 97.4 0.1 9.5e-28 96.5 0.1 1.5 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_2 PF13923.4 001133961.1_43527001_1 - 3e-15 55.6 10.3 3e-15 55.6 10.3 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001133961.1_43527001_1 - 1.4e-09 37.6 10.4 3.7e-09 36.2 10.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001133961.1_43527001_1 - 2.5e-08 33.9 8.5 2.5e-08 33.9 8.5 3.1 4 0 0 4 4 2 1 Ring finger domain zf-C3HC4_3 PF13920.4 001133961.1_43527001_1 - 3.2e-07 30.0 7.8 3.2e-07 30.0 7.8 2.4 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001133961.1_43527001_1 - 5.1e-05 23.1 8.0 0.00015 21.6 8.0 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.4 001133961.1_43527001_1 - 0.00012 21.9 8.5 0.00012 21.9 8.5 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.4 001133961.1_43527001_1 - 0.00035 20.5 7.6 0.00035 20.5 7.6 2.6 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.6 001133961.1_43527001_1 - 0.00074 19.2 5.5 0.0014 18.3 5.5 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.5 001133961.1_43527001_1 - 0.0011 19.1 8.3 0.0058 16.8 5.5 2.7 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_6 PF14835.4 001133961.1_43527001_1 - 0.0028 17.4 3.7 0.007 16.1 3.7 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_4 PF14570.4 001133961.1_43527001_1 - 0.0038 16.8 7.2 0.0038 16.8 7.2 2.5 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-C3HC4_5 PF17121.3 001133961.1_43527001_1 - 0.21 11.4 6.8 0.88 9.4 6.9 2.0 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-UDP PF14569.4 001133961.1_43527001_1 - 0.25 11.4 1.9 0.6 10.1 1.9 1.6 1 0 0 1 1 1 0 Zinc-binding RING-finger PET PF06297.12 001127634.1_39726001_2 - 1.4e-40 137.3 2.7 2.6e-40 136.5 2.7 1.5 1 0 0 1 1 1 1 PET Domain LIM PF00412.20 001127634.1_39726001_2 - 7.6e-26 90.0 62.4 9e-14 51.3 8.1 4.7 5 1 1 6 6 6 3 LIM domain Ig_Tie2_1 PF10430.7 001127634.1_39726001_2 - 0.053 13.8 0.0 0.23 11.8 0.0 2.1 1 0 0 1 1 1 0 Tie-2 Ig-like domain 1 IL1 PF00340.17 001009213.2_22422001_1 - 2.5e-30 104.5 0.5 4e-30 103.8 0.5 1.3 1 0 0 1 1 1 1 Interleukin-1 / 18 PRY PF13765.4 001071819.1_39723001_1 - 2.4e-18 65.3 0.1 6.7e-18 63.9 0.1 1.8 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.26 001071819.1_39723001_1 - 1.1e-11 44.8 0.0 2e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.22 001071819.1_39723001_1 - 3.6e-09 36.5 1.6 3.6e-09 36.5 1.6 3.6 3 1 0 3 3 3 1 B-box zinc finger zf-C3HC4_4 PF15227.4 001071819.1_39723001_1 - 4.2e-09 36.3 11.3 4.2e-09 36.3 11.3 2.8 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 001071819.1_39723001_1 - 7.3e-09 35.4 11.3 5e-08 32.7 6.2 2.9 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001071819.1_39723001_1 - 7.6e-09 35.2 9.3 7.6e-09 35.2 9.3 2.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001071819.1_39723001_1 - 6.2e-08 32.3 7.3 6.2e-08 32.3 7.3 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001071819.1_39723001_1 - 4.3e-07 29.5 10.1 4.3e-07 29.5 10.1 2.5 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001071819.1_39723001_1 - 9.5e-07 28.9 12.7 1.1e-06 28.6 9.8 2.5 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.4 001071819.1_39723001_1 - 0.00011 21.9 7.9 0.00011 21.9 7.9 3.2 3 1 1 4 4 4 1 zinc-RING finger domain zf-rbx1 PF12678.5 001071819.1_39723001_1 - 0.0032 17.6 3.9 0.0032 17.6 3.9 2.6 2 0 0 2 2 2 1 RING-H2 zinc finger domain STAT_alpha PF01017.18 001071819.1_39723001_1 - 0.019 14.7 6.7 0.035 13.8 6.7 1.4 1 0 0 1 1 1 0 STAT protein, all-alpha domain U-box PF04564.13 001071819.1_39723001_1 - 0.15 12.1 0.3 0.6 10.2 0.0 2.1 2 0 0 2 2 2 0 U-box domain zf-Nse PF11789.6 001071819.1_39723001_1 - 0.17 11.6 6.4 0.42 10.3 6.2 1.8 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.4 001071819.1_39723001_1 - 0.6 9.9 16.3 0.24 11.2 10.6 3.0 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.3 001071819.1_39723001_1 - 1.9 8.5 12.2 0.042 13.9 3.0 2.9 3 0 0 3 3 3 0 zinc RING finger of MSL2 Baculo_IE-1 PF05290.9 001071819.1_39723001_1 - 2 8.2 9.9 0.088 12.6 2.0 2.4 2 1 1 3 3 3 0 Baculovirus immediate-early protein (IE-0) zf-RING_4 PF14570.4 001071819.1_39723001_1 - 4.8 6.9 17.4 0.36 10.5 9.9 2.8 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain Rad50_zn_hook PF04423.12 001071819.1_39723001_1 - 6.7 6.5 10.2 3.3 7.5 0.9 3.4 4 0 0 4 4 3 0 Rad50 zinc hook motif IBR PF01485.19 001071819.1_39723001_1 - 8.2 6.6 13.9 4.4 7.5 1.9 3.8 3 1 0 3 3 3 0 IBR domain, a half RING-finger domain Ammonium_transp PF00909.19 001032964.3_29623001_2 - 2.2e-88 296.5 27.7 2.8e-88 296.2 27.7 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Gram_pos_anchor PF00746.19 001032964.3_29623001_2 - 6.7 6.7 0.0 6.7 6.7 0.0 4.9 6 0 0 6 6 6 0 Gram positive anchor Kdo PF06293.12 001032964.3_29623001_3 - 0.14 11.4 0.0 0.2 10.8 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Trypsin PF00089.24 214054.1_49825001_1 - 1.8e-70 237.1 0.0 2.5e-70 236.6 0.0 1.2 1 0 0 1 1 1 1 Trypsin Kringle PF00051.16 214054.1_49825001_1 - 1.2e-42 144.0 15.7 8.7e-24 83.5 2.8 2.9 3 0 0 3 3 3 2 Kringle domain fn1 PF00039.16 214054.1_49825001_1 - 2.6e-09 37.0 5.4 8.3e-09 35.4 5.4 2.0 1 0 0 1 1 1 1 Fibronectin type I domain EGF PF00008.25 214054.1_49825001_1 - 2.4e-06 27.6 4.9 2.4e-06 27.6 4.9 3.1 2 0 0 2 2 2 1 EGF-like domain DUF1986 PF09342.9 214054.1_49825001_1 - 0.00024 21.3 0.0 0.00042 20.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 214054.1_49825001_1 - 0.00073 20.3 0.0 0.002 18.9 0.0 1.7 1 1 0 1 1 1 1 Trypsin-like peptidase domain hEGF PF12661.5 214054.1_49825001_1 - 0.03 14.9 4.1 0.03 14.9 4.1 3.8 3 0 0 3 3 3 0 Human growth factor-like EGF Sushi PF00084.18 001032917.2_29622001_1 - 1.1e-05 25.8 10.1 0.0032 17.9 2.2 2.4 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) TIM PF00121.16 001071782.1_39722001_1 - 1.5e-86 289.6 0.0 1.7e-86 289.4 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase RNA_pol_Rpa2_4 PF06883.10 001071782.1_39722001_1 - 0.018 14.9 0.0 1.3 9.0 0.0 2.4 2 0 0 2 2 2 0 RNA polymerase I, Rpa2 specific domain PAP2 PF01569.19 001042378.1_22425001_3 - 3.1e-17 62.5 3.5 7.5e-17 61.3 3.5 1.7 1 0 0 1 1 1 1 PAP2 superfamily DUF373 PF04123.11 001042378.1_22425001_3 - 0.16 11.3 0.2 0.25 10.6 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF373) WHEP-TRS PF00458.18 001082288.1_37925001_3 - 1.8e-21 75.9 0.1 3.3e-21 75.0 0.1 1.4 1 0 0 1 1 1 1 WHEP-TRS domain tRNA-synt_1b PF00579.23 001082288.1_37925001_3 - 1.6e-13 50.5 0.0 2.5e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) WD40 PF00400.30 001082170.1_37923001_1 - 8.4e-38 127.6 20.7 9e-07 29.4 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001082170.1_37923001_1 - 1.8e-13 50.5 0.2 0.11 12.7 0.0 5.6 1 1 5 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 001082170.1_37923001_1 - 1.2e-05 24.6 0.1 0.47 9.6 0.0 4.0 2 1 2 4 4 4 2 WD40-like domain Nup160 PF11715.6 001082170.1_37923001_1 - 0.039 12.4 1.7 4.7 5.6 0.1 3.3 2 2 2 4 4 4 0 Nucleoporin Nup120/160 Gmad1 PF10647.7 001082170.1_37923001_1 - 0.11 12.1 0.1 10 5.6 0.0 2.2 2 0 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain Interfer-bind PF09294.8 001082291.1_37924001_1 - 1.4e-24 86.2 0.1 2.8e-24 85.3 0.1 1.5 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III Tissue_fac PF01108.15 001082291.1_37924001_1 - 1.6e-23 82.4 0.6 1.6e-23 82.4 0.6 1.9 2 0 0 2 2 2 1 Tissue factor ECSCR PF15820.3 001082291.1_37924001_1 - 0.094 12.4 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator DUF515 PF04415.10 001082291.1_37924001_1 - 0.17 10.1 0.4 0.24 9.6 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Lipase PF00151.17 001009394.1_39524001_1 - 1.4e-132 441.9 0.0 2e-132 441.4 0.0 1.1 1 0 0 1 1 1 1 Lipase PLAT PF01477.21 001009394.1_39524001_1 - 3.1e-23 82.4 0.5 5.5e-23 81.6 0.5 1.4 1 0 0 1 1 1 1 PLAT/LH2 domain Abhydrolase_6 PF12697.5 001009394.1_39524001_1 - 2.1e-05 25.1 0.4 2.1e-05 25.1 0.4 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.18 001009394.1_39524001_1 - 0.00036 20.1 0.1 0.00056 19.5 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold 7tm_1 PF00001.19 001082790.1_37923001_1 - 5.6e-80 268.3 12.2 7e-80 268.0 12.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001082790.1_37923001_1 - 1.7e-11 43.9 10.8 2e-10 40.3 10.8 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001082790.1_37923001_1 - 3.9e-06 26.7 9.0 0.00015 21.5 2.7 2.3 2 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001082790.1_37923001_1 - 3.1e-05 23.3 5.2 3.1e-05 23.3 5.2 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF2207 PF09972.7 001082790.1_37923001_1 - 6 5.4 7.3 1.3 7.6 0.1 2.4 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) DUF1761 PF08570.8 001082790.1_37923001_1 - 6.5 6.9 9.6 1.8 8.7 0.1 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1761) Bombesin PF02044.15 001009321.1_39522001_1 - 2.6e-08 33.2 5.0 5.7e-08 32.1 5.0 1.6 1 0 0 1 1 1 1 Bombesin-like peptide Cation_efflux PF01545.19 022853.2_45726001_2 - 2.9e-45 154.3 0.7 4.6e-40 137.4 0.0 2.1 2 0 0 2 2 2 2 Cation efflux family DUF805 PF05656.12 022853.2_45726001_2 - 0.6 10.4 2.6 1.7 9.0 2.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF805) Methyltransf_22 PF13383.4 001025038.1_45723001_1 - 7.9e-10 38.6 0.0 1.1e-09 38.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_21 PF05050.10 001025038.1_45723001_1 - 4.5e-05 23.4 0.0 6.3e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain Trypsin PF00089.24 001082110.1_37923001_2 - 2.1e-54 184.6 0.0 2.6e-54 184.2 0.0 1.1 1 0 0 1 1 1 1 Trypsin Lipase PF00151.17 001082317.1_37923001_2 - 1.6e-163 543.7 0.0 1.9e-163 543.4 0.0 1.0 1 0 0 1 1 1 1 Lipase PLAT PF01477.21 001082317.1_37923001_2 - 2.4e-16 60.2 0.1 4.6e-16 59.3 0.1 1.5 1 0 0 1 1 1 1 PLAT/LH2 domain Abhydrolase_6 PF12697.5 001082317.1_37923001_2 - 0.0019 18.7 0.0 0.0034 17.9 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family NADH_4Fe-4S PF10589.7 001082317.1_37923001_2 - 0.0065 16.4 0.1 0.013 15.4 0.1 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region Abhydrolase_3 PF07859.11 001082317.1_37923001_2 - 0.017 14.9 0.0 0.025 14.3 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_1 PF00561.18 001082317.1_37923001_2 - 0.038 13.5 0.0 0.069 12.6 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Ser_hydrolase PF06821.11 001082317.1_37923001_2 - 0.081 12.7 0.0 1.1 8.9 0.0 2.2 1 1 0 1 1 1 0 Serine hydrolase Ribosomal_L16 PF00252.16 001168802.1_40422001_1 - 1.3e-44 151.3 0.3 1.5e-44 151.0 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Dishevelled PF02377.13 001012430.1_39725001_1 - 1.4e-58 197.7 25.0 1.4e-58 197.7 25.0 2.2 2 0 0 2 2 2 1 Dishevelled specific domain Dsh_C PF12316.6 001012430.1_39725001_1 - 4e-58 197.1 33.8 4e-58 197.1 33.8 3.5 2 2 0 2 2 2 1 Segment polarity protein dishevelled (Dsh) C terminal DIX PF00778.15 001012430.1_39725001_1 - 1.9e-31 107.6 0.1 3.2e-31 106.9 0.1 1.4 1 0 0 1 1 1 1 DIX domain PDZ PF00595.22 001012430.1_39725001_1 - 1.1e-20 73.7 0.4 1.9e-20 72.9 0.4 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) DEP PF00610.19 001012430.1_39725001_1 - 5.4e-16 58.3 0.1 1.2e-15 57.2 0.1 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PDZ_2 PF13180.4 001012430.1_39725001_1 - 0.0062 16.7 0.2 0.012 15.7 0.2 1.5 1 0 0 1 1 1 1 PDZ domain Shufflon_N PF04917.10 001012430.1_39725001_1 - 0.033 13.5 0.1 0.054 12.8 0.1 1.2 1 0 0 1 1 1 0 Bacterial shufflon protein, N-terminal constant region COX5A PF02284.14 001118913.1_39721001_1 - 1.7e-46 156.3 0.0 2.1e-46 156.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va GHBP PF12772.5 001042667.1_29625001_3 - 2.2e-128 427.9 3.4 2.9e-128 427.5 3.4 1.1 1 0 0 1 1 1 1 Growth hormone receptor binding EpoR_lig-bind PF09067.8 001042667.1_29625001_3 - 1.9e-10 40.7 1.9 1.9e-10 40.7 1.9 1.9 2 0 0 2 2 2 1 Erythropoietin receptor, ligand binding GSHPx PF00255.17 001085444.1_37922001_1 - 1.2e-36 124.4 0.0 1.6e-36 124.0 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase zf-H2C2_2 PF13465.4 001131323.1_43528001_1 - 0.00049 20.3 1.6 0.00049 20.3 1.6 4.5 5 0 0 5 5 5 1 Zinc-finger double domain zf-C2H2_4 PF13894.4 001131323.1_43528001_1 - 0.016 15.8 20.8 0.41 11.5 1.2 4.2 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.24 001131323.1_43528001_1 - 0.68 10.4 27.9 0.93 9.9 1.2 4.1 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-LYAR PF08790.9 001131323.1_43528001_1 - 5.8 6.8 13.5 0.1 12.4 0.7 3.3 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zf-H2C2_2 PF13465.4 001131323.1_43528001_2 - 0.00034 20.8 13.6 0.47 10.9 0.5 4.5 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.24 001131323.1_43528001_2 - 0.0052 17.0 16.5 0.0081 16.4 1.1 3.9 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001131323.1_43528001_3 - 4.7e-95 308.0 164.2 4.2e-08 33.2 1.2 19.7 20 0 0 20 20 20 18 Zinc-finger double domain zf-C2H2 PF00096.24 001131323.1_43528001_3 - 1.9e-63 207.4 169.9 2.2e-06 27.7 1.5 18.4 18 0 0 18 18 18 16 Zinc finger, C2H2 type KRAB PF01352.25 001131323.1_43528001_3 - 1.9e-26 91.3 0.2 3.6e-26 90.4 0.2 1.5 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 001131323.1_43528001_3 - 4.4e-26 89.2 157.3 0.0091 16.6 0.9 17.7 18 0 0 18 18 18 13 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001131323.1_43528001_3 - 1.5e-22 78.9 126.6 0.0042 16.9 2.5 17.6 17 1 0 17 17 17 13 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001131323.1_43528001_3 - 1e-11 44.6 92.4 0.021 14.8 2.7 13.5 8 4 7 15 15 15 11 Zinc ribbon domain zf-C2H2_11 PF16622.3 001131323.1_43528001_3 - 2.6e-07 30.1 83.5 0.052 13.2 0.6 14.5 15 0 0 15 15 15 8 zinc-finger C2H2-type zf-H2C2_5 PF13909.4 001131323.1_43528001_3 - 0.0036 16.9 0.6 0.0036 16.9 0.6 18.0 19 5 0 19 19 19 2 C2H2-type zinc-finger domain XPA_N PF01286.16 001131323.1_43528001_3 - 1 9.3 78.8 5 7.1 0.1 15.9 17 0 0 17 17 17 0 XPA protein N-terminal zf-met PF12874.5 001131323.1_43528001_3 - 7.7 6.9 110.1 0.23 11.7 0.5 16.0 16 0 0 16 16 16 0 Zinc-finger of C2H2 type IL12 PF03039.12 001009833.1_22422001_1 - 1.1e-118 394.2 8.6 1.3e-118 394.0 8.6 1.0 1 0 0 1 1 1 1 Interleukin-12 alpha subunit IRK PF01007.18 001082017.1_37923001_1 - 2.1e-136 454.1 0.1 2.6e-136 453.8 0.1 1.0 1 0 0 1 1 1 1 Inward rectifier potassium channel EI24 PF07264.9 001082017.1_37923001_1 - 0.056 13.5 5.3 0.09 12.9 5.3 1.3 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) Ion_trans_2 PF07885.14 001082017.1_37923001_1 - 0.12 12.2 5.3 0.3 11.0 5.3 1.7 1 1 0 1 1 1 0 Ion channel Pur_ac_phosph_N PF16656.3 001035522.1_39724001_1 - 0.022 15.2 0.0 0.038 14.4 0.0 1.5 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain IL6Ra-bind PF09240.8 001035522.1_39724001_1 - 0.038 14.3 2.8 0.066 13.5 2.1 1.8 2 0 0 2 2 2 0 Interleukin-6 receptor alpha chain, binding GSHPx PF00255.17 213886.1_49823001_1 - 7.5e-44 147.6 0.6 1.1e-43 147.1 0.6 1.2 1 0 0 1 1 1 1 Glutathione peroxidase 40S_SA_C PF16122.3 001105263.1_39522001_1 - 1.2e-27 96.9 16.3 2.2e-27 96.1 16.3 1.4 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus Ribosomal_S2 PF00318.18 001105263.1_39522001_1 - 1.1e-25 90.0 0.0 1.3e-12 47.3 0.0 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 TNF PF00229.16 001024860.1_39524001_2 - 1.6e-38 131.4 0.0 2.5e-38 130.7 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family EF-hand_6 PF13405.4 001101713.1_37922001_2 - 1.3e-10 40.2 0.8 2.3e-05 23.8 0.0 3.4 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.30 001101713.1_37922001_2 - 3.1e-10 38.7 0.5 0.0066 15.8 0.0 4.2 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.4 001101713.1_37922001_2 - 4.4e-07 30.1 0.0 0.0084 16.4 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.4 001101713.1_37922001_2 - 0.006 16.8 0.0 1.3 9.3 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.4 001101713.1_37922001_2 - 0.016 14.9 0.4 2.1 8.1 0.1 2.6 1 1 1 2 2 2 0 EF-hand domain pair Ribosomal_60s PF00428.17 001101713.1_37922001_2 - 2.2 8.8 14.6 1.3 9.5 8.6 2.9 3 0 0 3 3 3 0 60s Acidic ribosomal protein DUF3597 PF12200.6 001101713.1_37922001_2 - 6.6 7.2 6.0 3.3 8.1 3.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) Ribosomal_L30_N PF08079.10 001132408.2_43523001_1 - 5.8e-30 103.2 15.1 1.1e-29 102.3 15.1 1.5 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.18 001132408.2_43523001_1 - 6.5e-26 89.9 2.8 1.3e-25 88.9 1.4 2.3 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e 7tm_1 PF00001.19 001009397.1_39525001_2 - 1.1e-39 136.2 13.8 1.5e-39 135.7 13.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3307 PF11750.6 001009397.1_39525001_2 - 0.032 14.2 0.7 0.078 12.9 0.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3307) Ig_2 PF13895.4 001042622.1_39724001_1 - 1.6e-15 57.0 0.2 1.1e-09 38.4 0.0 2.9 3 1 0 3 3 3 2 Immunoglobulin domain V-set PF07686.15 001042622.1_39724001_1 - 2e-14 53.5 0.0 1.6e-10 40.9 0.0 3.6 3 1 1 4 4 4 2 Immunoglobulin V-set domain Ig_3 PF13927.4 001042622.1_39724001_1 - 3e-14 53.2 0.2 1.9e-08 34.7 0.0 3.6 2 1 2 4 4 4 2 Immunoglobulin domain I-set PF07679.14 001042622.1_39724001_1 - 1.4e-12 47.4 0.0 5.2e-08 32.7 0.0 3.2 3 1 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.23 001042622.1_39724001_1 - 1.6e-11 44.1 0.0 1.3e-05 25.1 0.0 3.6 3 1 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.10 001042622.1_39724001_1 - 1e-05 25.4 0.7 0.018 15.0 0.0 3.2 2 1 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Pkinase PF00069.23 001113219.1_49824001_3 - 1.9e-40 138.7 0.0 2.8e-40 138.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001113219.1_49824001_3 - 1.3e-36 126.1 0.0 1.6e-36 125.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase CFTR_R PF14396.4 001082716.1_37929001_2 - 7.5e-100 332.7 2.9 1.3e-99 331.9 2.9 1.4 1 0 0 1 1 1 1 Cystic fibrosis TM conductance regulator (CFTR), regulator domain ABC_membrane PF00664.21 001082716.1_37929001_2 - 1e-91 307.3 41.9 5.3e-50 170.5 20.1 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 001082716.1_37929001_2 - 2.3e-60 202.9 0.0 2.6e-33 115.3 0.0 2.8 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.4 001082716.1_37929001_2 - 5.8e-08 32.8 0.3 0.023 14.4 0.0 3.4 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.17 001082716.1_37929001_2 - 2.2e-07 30.4 0.0 0.031 13.6 0.0 3.4 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.4 001082716.1_37929001_2 - 1.6e-06 27.6 0.7 0.00066 19.2 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain T2SSE PF00437.18 001082716.1_37929001_2 - 2.2e-06 26.8 0.2 0.013 14.4 0.1 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein DUF258 PF03193.14 001082716.1_37929001_2 - 1e-05 25.4 0.5 0.029 14.1 0.1 2.8 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.4 001082716.1_37929001_2 - 6.5e-05 23.2 0.0 0.26 11.5 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.15 001082716.1_37929001_2 - 0.00011 22.2 0.8 0.06 13.2 0.1 2.8 2 0 0 2 2 2 1 Domain of unknown function DUF87 Zeta_toxin PF06414.10 001082716.1_37929001_2 - 0.00056 19.1 0.4 0.15 11.2 0.1 2.6 2 0 0 2 2 2 1 Zeta toxin ArgK PF03308.14 001082716.1_37929001_2 - 0.00062 18.7 0.7 0.0095 14.8 0.1 2.3 2 0 0 2 2 2 1 ArgK protein MMR_HSR1 PF01926.21 001082716.1_37929001_2 - 0.00069 19.6 0.0 0.23 11.4 0.0 3.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase NACHT PF05729.10 001082716.1_37929001_2 - 0.00071 19.4 0.6 1.3 8.7 0.1 2.8 2 0 0 2 2 2 2 NACHT domain Roc PF08477.11 001082716.1_37929001_2 - 0.0016 18.6 0.2 3.5 7.8 0.0 3.7 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.4 001082716.1_37929001_2 - 0.0026 17.9 1.0 2.7 8.1 0.0 3.2 3 0 0 3 3 2 1 AAA domain NTPase_1 PF03266.13 001082716.1_37929001_2 - 0.0055 16.5 0.2 0.27 11.0 0.0 2.7 3 0 0 3 3 2 1 NTPase AAA_24 PF13479.4 001082716.1_37929001_2 - 0.012 15.2 0.7 3.5 7.2 0.0 3.4 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.4 001082716.1_37929001_2 - 0.014 15.0 0.0 0.74 9.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain TsaE PF02367.15 001082716.1_37929001_2 - 0.017 15.0 0.3 9.3 6.1 0.1 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.4 001082716.1_37929001_2 - 0.018 15.2 0.1 14 5.9 0.0 3.2 2 1 0 2 2 2 0 AAA domain MobB PF03205.12 001082716.1_37929001_2 - 0.03 14.1 1.6 11 5.7 0.1 3.3 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B NB-ARC PF00931.20 001082716.1_37929001_2 - 0.031 13.2 0.2 1.1 8.1 0.0 2.7 2 0 0 2 2 2 0 NB-ARC domain FtsK_SpoIIIE PF01580.16 001082716.1_37929001_2 - 0.031 13.5 0.5 4.1 6.5 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family cobW PF02492.17 001082716.1_37929001_2 - 0.05 13.1 1.8 4.3 6.8 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.4 001082716.1_37929001_2 - 0.052 13.9 10.7 0.85 10.0 0.0 4.1 4 0 0 4 4 4 0 AAA domain TrwB_AAD_bind PF10412.7 001082716.1_37929001_2 - 0.18 10.6 1.5 4.9 5.8 0.1 2.7 2 1 1 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain AAA_25 PF13481.4 001082716.1_37929001_2 - 0.22 11.0 0.4 9.1 5.7 0.1 2.4 2 0 0 2 2 2 0 AAA domain Carb_anhydrase PF00194.19 001082086.1_37923001_1 - 4.4e-89 298.2 0.0 5.2e-89 298.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase DUF3149 PF11346.6 001082086.1_37923001_1 - 0.29 10.6 0.8 0.55 9.8 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) Filament PF00038.19 001114761.1_39524001_1 - 7e-110 367.3 30.0 8.2e-110 367.1 30.0 1.0 1 0 0 1 1 1 1 Intermediate filament protein Lzipper-MIP1 PF14389.4 001114761.1_39524001_1 - 0.0067 16.5 3.0 0.0067 16.5 3.0 4.0 3 2 0 3 3 3 1 Leucine-zipper of ternary complex factor MIP1 TPR_MLP1_2 PF07926.10 001114761.1_39524001_1 - 0.012 15.5 33.1 0.23 11.4 3.2 3.9 3 2 0 3 3 3 0 TPR/MLP1/MLP2-like protein Uso1_p115_C PF04871.11 001114761.1_39524001_1 - 0.13 12.5 17.9 0.48 10.7 3.9 2.9 2 2 1 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Baculo_PEP_C PF04513.10 001114761.1_39524001_1 - 0.26 11.2 12.3 2.2 8.2 6.8 3.1 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2935 PF11155.6 001114761.1_39524001_1 - 0.36 11.0 3.2 23 5.2 4.0 3.0 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) ADIP PF11559.6 001114761.1_39524001_1 - 0.37 10.8 23.8 0.22 11.5 0.5 3.7 2 2 1 3 3 3 0 Afadin- and alpha -actinin-Binding DUF3287 PF11690.6 001114761.1_39524001_1 - 0.42 10.2 1.9 1.6 8.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3287) T6SS_VipA PF05591.10 001114761.1_39524001_1 - 0.97 9.1 7.0 0.31 10.7 3.0 2.2 2 1 0 2 2 2 0 Type VI secretion system, VipA, VC_A0107 or Hcp2 G6PD_N PF00479.20 001114761.1_39524001_1 - 1.1 9.8 8.0 1.6 9.2 0.1 3.0 2 1 1 3 3 3 0 Glucose-6-phosphate dehydrogenase, NAD binding domain DUF5082 PF16888.3 001114761.1_39524001_1 - 1.2 9.4 16.2 0.078 13.2 4.5 3.3 2 1 0 3 3 3 0 Domain of unknown function (DUF5082) Atg14 PF10186.7 001114761.1_39524001_1 - 1.6 7.6 20.3 3.1e+03 -3.2 20.4 2.6 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ERM PF00769.17 001114761.1_39524001_1 - 2.6 7.7 21.2 0.054 13.2 4.8 2.2 1 1 1 2 2 1 0 Ezrin/radixin/moesin family DUF1664 PF07889.10 001114761.1_39524001_1 - 2.7 7.9 15.2 2.6 7.9 2.3 3.9 2 2 1 4 4 4 0 Protein of unknown function (DUF1664) Nsp1_C PF05064.11 001114761.1_39524001_1 - 4.4 7.0 16.8 0.1 12.2 7.0 2.7 2 1 0 2 2 2 0 Nsp1-like C-terminal region Jnk-SapK_ap_N PF09744.7 001114761.1_39524001_1 - 5 7.2 29.0 2.9 8.0 4.0 3.8 2 2 1 4 4 4 0 JNK_SAPK-associated protein-1 Bacillus_HBL PF05791.9 001114761.1_39524001_1 - 6 6.4 9.7 1.1 8.9 2.9 2.7 2 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) CREPT PF16566.3 001114761.1_39524001_1 - 7 6.7 24.1 1.8 8.6 3.6 3.6 3 1 0 4 4 3 0 Cell-cycle alteration and expression-elevated protein in tumour PspA_IM30 PF04012.10 001114761.1_39524001_1 - 7.3 6.0 22.7 0.49 9.8 8.4 3.4 2 1 1 3 3 3 0 PspA/IM30 family Phage_GPO PF05929.9 001114761.1_39524001_1 - 7.4 6.0 9.0 1.5 8.3 4.3 2.0 1 1 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF724 PF05266.12 001114761.1_39524001_1 - 8.2 6.1 13.6 4.8 6.8 4.8 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF724) AdoHcyase PF05221.15 001132702.1_43529001_1 - 1e-121 405.5 0.0 4.6e-65 219.5 0.1 2.1 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.19 001132702.1_43529001_1 - 4.7e-81 270.5 2.1 6.5e-81 270.0 2.1 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.17 001132702.1_43529001_1 - 1.1e-08 34.5 0.1 2e-08 33.6 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.17 001132702.1_43529001_1 - 0.00059 19.1 0.9 0.0014 17.8 0.9 1.5 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.18 001132702.1_43529001_1 - 0.0015 18.5 0.1 0.003 17.5 0.1 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase IlvN PF07991.10 001132702.1_43529001_1 - 0.0024 17.3 0.0 0.0041 16.6 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_7 PF13241.4 001132702.1_43529001_1 - 0.017 15.4 0.5 0.032 14.5 0.5 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding TrkA_N PF02254.16 001132702.1_43529001_1 - 0.041 14.0 0.1 0.096 12.8 0.1 1.5 1 1 0 1 1 1 0 TrkA-N domain AlaDh_PNT_C PF01262.19 001132702.1_43529001_1 - 0.06 12.5 0.5 0.13 11.4 0.5 1.4 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain SR-25 PF10500.7 001132702.1_43529001_1 - 0.69 9.3 9.7 1.1 8.7 9.7 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Kunitz_BPTI PF00014.21 001009291.1_39523001_1 - 2.5e-19 69.1 8.6 4.1e-19 68.4 8.6 1.4 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain ZapB PF06005.10 001009291.1_39523001_1 - 0.0029 17.9 1.9 0.87 10.0 0.1 2.3 2 0 0 2 2 2 2 Cell division protein ZapB GIT_CC PF16559.3 001009291.1_39523001_1 - 0.097 12.6 1.1 0.4 10.6 0.2 2.1 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Coatomer_E PF04733.12 001083623.1_39721001_2 - 0.23 10.7 0.0 0.3 10.3 0.0 1.0 1 0 0 1 1 1 0 Coatomer epsilon subunit DAP10 PF07213.9 001083623.1_39721001_3 - 0.00075 19.3 2.8 0.0011 18.7 2.8 1.3 1 0 0 1 1 1 1 DAP10 membrane protein Ank_3 PF13606.4 001045507.1_39723001_1 - 5.4e-06 26.2 0.7 0.3 11.6 0.3 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.4 001045507.1_39723001_1 - 1.1e-05 25.7 0.7 5.1e-05 23.6 0.6 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.4 001045507.1_39723001_1 - 3.7e-05 23.8 7.0 0.00032 20.8 2.4 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.5 001045507.1_39723001_1 - 4.8e-05 23.7 0.0 9.4e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.28 001045507.1_39723001_1 - 0.0025 18.1 3.8 1.5 9.3 1.1 2.6 2 0 0 2 2 2 2 Ankyrin repeat Sec62 PF03839.14 001134176.1_43529001_3 - 1.6e-75 253.2 5.1 1.6e-75 253.2 5.1 2.3 3 0 0 3 3 3 1 Translocation protein Sec62 DEP PF00610.19 001134176.1_43529001_3 - 0.069 13.1 0.0 0.19 11.7 0.0 1.7 1 0 0 1 1 1 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Pkinase PF00069.23 001101690.1_37924001_1 - 7.3e-70 235.2 0.0 1.2e-69 234.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001101690.1_37924001_1 - 1.5e-36 125.9 0.0 1.9e-36 125.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.22 001101690.1_37924001_1 - 3.3e-10 40.4 3.8 8.6e-10 39.0 3.8 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 001101690.1_37924001_1 - 3.5e-07 29.7 0.0 8.9e-07 28.4 0.0 1.6 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.4 001101690.1_37924001_1 - 0.056 12.9 0.1 6.1 6.3 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 ABC_membrane PF00664.21 172912.4_32929001_1 - 2e-52 178.4 45.9 1.4e-32 113.3 18.1 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 172912.4_32929001_1 - 1.8e-51 174.1 0.1 4.8e-28 98.3 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 172912.4_32929001_1 - 4.1e-11 42.6 9.1 0.0021 17.4 0.1 4.3 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain DUF258 PF03193.14 172912.4_32929001_1 - 2.1e-05 24.3 2.2 0.005 16.6 0.1 2.9 3 0 0 3 3 3 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.21 172912.4_32929001_1 - 3.4e-05 23.8 1.0 0.37 10.8 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.4 172912.4_32929001_1 - 3.5e-05 23.3 1.6 0.21 11.2 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.4 172912.4_32929001_1 - 4.7e-05 23.2 3.0 3.2 7.3 0.0 4.3 3 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system T2SSE PF00437.18 172912.4_32929001_1 - 0.00037 19.5 0.0 0.83 8.5 0.0 3.2 3 0 0 3 3 3 2 Type II/IV secretion system protein AAA_16 PF13191.4 172912.4_32929001_1 - 0.0026 18.0 0.1 4.1 7.6 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.4 172912.4_32929001_1 - 0.0034 17.8 1.3 2.7 8.3 0.1 2.4 2 0 0 2 2 2 2 AAA domain Dynamin_N PF00350.21 172912.4_32929001_1 - 0.0036 17.3 0.9 0.062 13.2 0.1 2.4 2 0 0 2 2 2 1 Dynamin family DUF87 PF01935.15 172912.4_32929001_1 - 0.0041 17.1 2.6 0.063 13.2 0.1 2.4 2 0 0 2 2 2 1 Domain of unknown function DUF87 ArgK PF03308.14 172912.4_32929001_1 - 0.01 14.7 0.7 0.11 11.3 0.1 2.2 2 0 0 2 2 2 0 ArgK protein AAA_22 PF13401.4 172912.4_32929001_1 - 0.012 15.8 2.0 1.3 9.2 0.1 2.9 2 1 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.23 172912.4_32929001_1 - 0.021 14.4 0.0 7.5 6.0 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain IstB_IS21 PF01695.15 172912.4_32929001_1 - 0.03 14.0 0.2 13 5.4 0.0 3.0 3 0 0 3 3 3 0 IstB-like ATP binding protein DUF815 PF05673.11 172912.4_32929001_1 - 0.055 12.5 0.3 4.3 6.3 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Zeta_toxin PF06414.10 172912.4_32929001_1 - 0.064 12.4 2.7 0.38 9.9 0.2 2.6 3 0 0 3 3 3 0 Zeta toxin cobW PF02492.17 172912.4_32929001_1 - 0.074 12.5 2.8 0.33 10.4 0.1 2.7 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain TrwB_AAD_bind PF10412.7 172912.4_32929001_1 - 0.26 10.0 1.0 7.9 5.1 0.1 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain zf-RING_UBOX PF13445.4 001131364.1_43524001_1 - 3.3e-10 39.7 4.0 8.8e-10 38.3 4.0 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 001131364.1_43524001_1 - 1.9e-08 33.8 2.7 1.9e-08 33.8 2.7 2.4 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001131364.1_43524001_1 - 2.5e-07 30.3 3.9 2.5e-07 30.3 3.9 2.8 3 2 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001131364.1_43524001_1 - 7.2e-07 28.9 5.0 7.2e-07 28.9 5.0 2.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.4 001131364.1_43524001_1 - 3.2e-06 27.1 6.7 3.2e-06 27.1 6.7 2.5 2 1 0 2 2 1 1 Ring finger domain zf-B_box PF00643.22 001131364.1_43524001_1 - 4.6e-06 26.5 8.1 4.6e-06 26.5 8.1 3.4 4 0 0 4 4 4 1 B-box zinc finger zf-C3HC4_4 PF15227.4 001131364.1_43524001_1 - 9.4e-06 25.6 6.3 9.4e-06 25.6 6.3 2.8 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 001131364.1_43524001_1 - 3.1e-05 23.6 8.4 3.1e-05 23.6 8.4 3.0 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 001131364.1_43524001_1 - 0.00013 21.6 0.3 0.00013 21.6 0.3 2.0 2 0 0 2 2 2 1 zf-RING of BARD1-type protein DUF349 PF03993.10 001131364.1_43524001_1 - 0.0093 16.1 1.5 0.034 14.3 1.6 2.0 1 1 0 1 1 1 1 Domain of Unknown Function (DUF349) UvrD_C PF13361.4 001131364.1_43524001_1 - 0.056 12.7 0.4 0.085 12.1 0.4 1.1 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Fmp27_WPPW PF10359.7 001131364.1_43524001_1 - 0.089 11.5 1.8 0.13 11.0 1.8 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF2431 PF10354.7 001131364.1_43524001_1 - 0.095 12.9 0.1 0.17 12.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) IL12p40_C PF10420.7 001112635.1_40423001_3 - 5.1e-22 78.0 0.5 5.1e-22 78.0 0.5 2.2 2 0 0 2 2 2 1 Cytokine interleukin-12p40 C-terminus Ig_5 PF16681.3 001112635.1_40423001_3 - 1e-05 25.7 0.2 8.4e-05 22.8 0.0 2.4 1 1 1 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_2 PF13895.4 001112635.1_40423001_3 - 1.1e-05 25.6 0.1 0.00024 21.3 0.0 2.5 1 1 1 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.4 001112635.1_40423001_3 - 5.7e-05 23.5 6.5 0.00033 21.1 0.0 3.0 3 1 0 3 3 3 1 Immunoglobulin domain Ig_4 PF16680.3 001112635.1_40423001_3 - 0.00011 22.4 0.1 0.00062 19.9 0.0 2.3 1 1 1 2 2 2 1 T-cell surface glycoprotein CD3 delta chain fn3 PF00041.19 001112635.1_40423001_3 - 0.00019 21.6 0.1 0.0013 18.9 0.1 2.3 2 0 0 2 2 2 1 Fibronectin type III domain I-set PF07679.14 001112635.1_40423001_3 - 0.04 13.8 1.2 0.74 9.8 0.1 3.4 4 1 0 4 4 4 0 Immunoglobulin I-set domain V-set PF07686.15 001112635.1_40423001_3 - 0.16 12.0 3.5 16 5.6 0.0 3.5 3 1 1 4 4 4 0 Immunoglobulin V-set domain Sugar_tr PF00083.22 001082115.1_37925001_1 - 6.4e-34 117.4 11.8 1.1e-33 116.7 11.8 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001082115.1_37925001_1 - 3.1e-24 85.4 27.3 9.8e-19 67.3 16.0 2.7 2 1 1 3 3 3 2 Major Facilitator Superfamily ETRAMP PF09716.8 001082115.1_37925001_3 - 0.18 11.7 4.7 0.33 10.9 4.7 1.4 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Atrophin-1 PF03154.13 001034165.1_39728001_1 - 5.4e-236 786.2 238.2 6e-212 706.6 123.7 3.4 1 1 2 3 3 3 2 Atrophin-1 family MIP-T3 PF10243.7 001034165.1_39728001_1 - 0.004 15.8 1.1 0.004 15.8 1.1 3.1 3 0 0 3 3 3 1 Microtubule-binding protein MIP-T3 Spt20 PF12090.6 001034165.1_39728001_1 - 3.1 7.2 15.9 0.06 12.8 5.9 2.3 2 0 0 2 2 2 0 Spt20 family PET PF06297.12 001168690.1_32325001_1 - 4.5e-40 135.7 2.1 7e-40 135.1 2.1 1.3 1 0 0 1 1 1 1 PET Domain LIM PF00412.20 001168690.1_32325001_1 - 6.4e-26 90.2 58.7 9.8e-14 51.2 7.5 4.9 4 1 1 5 5 5 3 LIM domain Pkinase PF00069.23 001082306.1_37929001_2 - 3.1e-76 256.1 0.0 4.5e-76 255.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.14 001082306.1_37929001_2 - 9e-66 217.9 0.5 1.9e-27 95.0 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.4 001082306.1_37929001_2 - 3.5e-38 129.9 0.1 7.3e-13 48.8 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain Pkinase_Tyr PF07714.15 001082306.1_37929001_2 - 3.6e-35 121.4 0.0 5.5e-35 120.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase ig PF00047.23 001082306.1_37929001_2 - 7.6e-26 90.0 0.9 3e-10 40.0 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 001082306.1_37929001_2 - 1.1e-21 76.8 1.1 4.5e-10 39.6 0.1 3.5 3 0 0 3 3 3 3 Immunoglobulin domain fn3 PF00041.19 001082306.1_37929001_2 - 9.5e-16 57.8 0.1 1.8e-15 56.9 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III domain V-set PF07686.15 001082306.1_37929001_2 - 1.7e-10 40.9 1.6 0.096 12.7 0.1 5.3 3 2 0 3 3 3 2 Immunoglobulin V-set domain DUF4573 PF15140.4 001082306.1_37929001_2 - 4.4e-06 26.5 22.9 0.001 18.8 10.8 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF4573) C2-set_2 PF08205.10 001082306.1_37929001_2 - 1.6e-05 24.7 0.0 0.01 15.7 0.1 2.8 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Kinase-like PF14531.4 001082306.1_37929001_2 - 0.00022 20.5 0.0 0.00035 19.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 001082306.1_37929001_2 - 0.021 14.0 0.0 0.05 12.8 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family IRK PF01007.18 001082198.1_37925001_3 - 1.1e-155 517.5 1.6 1.4e-155 517.1 1.6 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel IRK_N PF08466.8 001082198.1_37925001_3 - 3.5e-26 90.9 1.3 7e-26 90.0 1.3 1.5 1 0 0 1 1 1 1 Inward rectifier potassium channel N-terminal Ion_trans_2 PF07885.14 001082198.1_37925001_3 - 0.00035 20.4 5.2 0.00035 20.4 5.2 2.0 2 0 0 2 2 2 1 Ion channel PX PF00787.22 001133205.1_43523001_3 - 1.3e-27 95.8 0.0 2.6e-27 94.9 0.0 1.5 1 0 0 1 1 1 1 PX domain Myosin_tail_1 PF01576.17 001082308.1_37929001_1 - 0 1685.9 314.9 0 1685.6 314.9 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.19 001082308.1_37929001_1 - 0 1025.3 2.9 0 1025.3 2.9 4.2 5 0 0 5 5 5 1 Myosin head (motor domain) Myosin_N PF02736.17 001082308.1_37929001_1 - 1.7e-14 53.2 4.5 4.4e-14 51.9 4.5 1.8 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain IQ PF00612.25 001082308.1_37929001_1 - 0.00075 19.0 0.1 0.0029 17.1 0.1 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif Reo_sigmaC PF04582.10 001082308.1_37929001_1 - 0.0036 16.6 5.6 0.0036 16.6 5.6 9.0 3 2 5 9 9 9 5 Reovirus sigma C capsid protein CC2-LZ PF16516.3 001082308.1_37929001_1 - 0.0051 17.0 19.2 0.0051 17.0 19.2 17.7 3 2 15 18 18 18 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator AAA_22 PF13401.4 001082308.1_37929001_1 - 0.08 13.1 0.0 0.08 13.1 0.0 8.2 6 2 3 10 10 10 0 AAA domain IL1_propep PF02394.14 001009808.1_39522001_1 - 1.1e-40 138.8 3.1 1.1e-40 138.8 3.1 1.7 2 0 0 2 2 2 1 Interleukin-1 propeptide IL1 PF00340.17 001009808.1_39522001_1 - 1.1e-37 128.2 0.2 2.1e-37 127.3 0.2 1.4 1 0 0 1 1 1 1 Interleukin-1 / 18 DUF4937 PF16291.3 001009808.1_39522001_1 - 0.073 13.2 0.6 0.27 11.4 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4937 7tm_1 PF00001.19 153722.2_45725001_2 - 3.7e-10 39.3 17.2 2.6e-09 36.6 17.2 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.7 153722.2_45725001_2 - 0.00068 18.9 9.9 0.0012 18.1 9.9 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx CECR6_TMEM121 PF14997.4 153722.2_45725001_2 - 0.0063 16.2 3.9 0.0098 15.6 3.9 1.3 1 0 0 1 1 1 1 CECR6/TMEM121 family DUF2165 PF09933.7 153722.2_45725001_2 - 0.98 9.3 3.7 2.2 8.1 0.4 2.3 1 1 1 2 2 2 0 Predicted small integral membrane protein (DUF2165) Death PF00531.20 001032933.2_29623001_1 - 2.5e-17 62.7 0.2 5.2e-17 61.7 0.1 1.6 2 0 0 2 2 2 1 Death domain TNFR_c6 PF00020.16 001032933.2_29623001_1 - 4.9e-17 61.9 38.8 1.9e-09 37.7 9.3 3.8 3 0 0 3 3 3 3 TNFR/NGFR cysteine-rich region Peptidase_C8 PF03569.11 001032933.2_29623001_1 - 0.023 14.1 0.7 0.04 13.3 0.5 1.4 2 0 0 2 2 2 0 Peptidase family C8 Stn1_C PF12659.5 001032933.2_29623001_1 - 0.071 12.9 0.1 0.16 11.8 0.1 1.6 1 1 0 1 1 1 0 Telomere capping C-terminal wHTH HlyIII PF03006.18 213740.1_49826001_1 - 4.3e-50 170.4 19.5 6.9e-50 169.7 19.5 1.3 1 0 0 1 1 1 1 Haemolysin-III related Sushi PF00084.18 213835.1_49823001_1 - 8.4e-05 23.0 10.7 0.033 14.7 2.7 2.6 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) SOG2 PF10428.7 213835.1_49823001_1 - 0.037 13.2 1.1 0.058 12.5 1.1 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein Glyco_transf_64 PF09258.8 001168973.1_40425001_1 - 2.8e-105 350.9 0.6 4e-105 350.4 0.6 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Exostosin PF03016.13 001168973.1_40425001_1 - 8.8e-63 212.2 0.0 1.8e-62 211.2 0.0 1.5 1 0 0 1 1 1 1 Exostosin family LRR_8 PF13855.4 001011555.1_39527001_2 - 1.1e-81 268.4 75.7 5.3e-13 48.4 3.2 15.1 11 3 2 14 14 14 14 Leucine rich repeat LRR_4 PF12799.5 001011555.1_39527001_2 - 1.6e-40 136.1 65.8 0.0014 18.8 0.1 15.8 8 3 10 18 18 18 18 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001011555.1_39527001_2 - 1.6e-13 48.9 66.8 0.82 10.3 0.0 21.9 22 4 0 22 22 22 5 Leucine Rich Repeat LRR_6 PF13516.4 001011555.1_39527001_2 - 4.2e-09 35.6 69.7 0.37 10.8 0.0 19.9 22 0 0 22 22 22 4 Leucine Rich repeat LRR_9 PF14580.4 001011555.1_39527001_2 - 3.2e-06 26.6 19.9 0.13 11.6 0.2 7.1 5 3 2 7 7 7 2 Leucine-rich repeat TIR PF01582.18 001011555.1_39527001_2 - 5.6e-05 22.9 0.0 9.5e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 TIR domain LRR_5 PF13306.4 001011555.1_39527001_2 - 0.00022 21.1 0.0 0.85 9.5 0.0 3.8 4 0 0 4 4 4 2 Leucine rich repeats (6 copies) FNIP PF05725.10 001011555.1_39527001_2 - 0.0013 18.7 2.1 8.5 6.5 0.0 5.4 4 2 1 5 5 5 1 FNIP Repeat Globin PF00042.20 001078658.1_39522001_1 - 6e-21 74.9 1.3 8.6e-21 74.4 1.3 1.2 1 0 0 1 1 1 1 Globin HMA PF00403.24 001009429.1_39521001_2 - 1.4e-08 35.0 0.2 2.1e-08 34.3 0.2 1.3 1 0 0 1 1 1 1 Heavy-metal-associated domain Biopterin_H PF00351.19 001039946.1_29623001_1 - 2.8e-175 582.0 0.1 3.4e-175 581.7 0.1 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.23 001039946.1_29623001_1 - 0.008 15.8 0.1 0.032 13.9 0.0 2.0 2 0 0 2 2 2 1 ACT domain Gly_acyl_tr_N PF06021.9 001167907.1_32924001_2 - 1.1e-86 290.0 0.2 1.5e-86 289.6 0.2 1.2 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase Gly_acyl_tr_C PF08444.8 001167907.1_32924001_2 - 8.3e-43 144.4 1.6 1e-42 144.1 0.4 1.8 2 0 0 2 2 2 1 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region YhhN PF07947.12 001109604.1_45723001_1 - 5e-38 130.4 22.7 5e-38 130.4 22.7 1.4 2 0 0 2 2 2 1 YhhN family Tubulin PF00091.23 001098544.1_39724001_1 - 7.3e-69 231.8 0.0 9.7e-69 231.4 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 001098544.1_39724001_1 - 2.8e-51 172.8 0.0 4.4e-51 172.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 001098544.1_39724001_1 - 0.0019 17.8 0.0 0.0035 16.9 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain IL12p40_C PF10420.7 001077413.1_22423001_1 - 1.1e-23 83.3 2.4 2.5e-23 82.2 0.6 2.3 2 0 0 2 2 2 1 Cytokine interleukin-12p40 C-terminus Ig_3 PF13927.4 001077413.1_22423001_1 - 9e-08 32.5 5.1 9.2e-06 26.1 0.1 3.0 3 0 0 3 3 3 2 Immunoglobulin domain Ig_5 PF16681.3 001077413.1_22423001_1 - 6.1e-07 29.6 1.9 1.1e-05 25.6 0.1 2.6 1 1 1 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 001077413.1_22423001_1 - 7.9e-06 26.0 0.9 8e-05 22.8 0.1 2.5 1 1 2 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Ig_2 PF13895.4 001077413.1_22423001_1 - 0.00012 22.2 0.4 0.0024 18.1 0.0 2.7 1 1 1 2 2 2 1 Immunoglobulin domain fn3 PF00041.19 001077413.1_22423001_1 - 0.00031 20.9 3.9 0.0011 19.1 0.4 3.0 3 1 0 3 3 3 1 Fibronectin type III domain I-set PF07679.14 001077413.1_22423001_1 - 0.027 14.4 4.7 0.12 12.3 0.2 3.9 3 2 1 4 4 4 0 Immunoglobulin I-set domain V-set PF07686.15 001077413.1_22423001_1 - 0.045 13.8 4.4 5.6 7.0 0.0 3.8 3 1 1 4 4 4 0 Immunoglobulin V-set domain ig PF00047.23 001077413.1_22423001_1 - 0.082 13.0 0.1 0.082 13.0 0.1 2.5 3 0 0 3 3 3 0 Immunoglobulin domain IL1 PF00340.17 001077414.1_22422001_3 - 2.6e-47 159.3 0.9 5.1e-47 158.4 0.9 1.5 1 0 0 1 1 1 1 Interleukin-1 / 18 IL1_propep PF02394.14 001077414.1_22422001_3 - 1.8e-39 134.9 1.7 2.9e-39 134.2 0.2 1.9 2 0 0 2 2 2 1 Interleukin-1 propeptide Tubulin PF00091.23 001045509.1_39723001_1 - 3.2e-69 233.0 0.0 5e-69 232.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 001045509.1_39723001_1 - 2.7e-42 143.8 0.1 4.2e-42 143.2 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.7 001045509.1_39723001_1 - 1e-05 25.7 0.0 2.5e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.4 001045509.1_39723001_1 - 0.006 16.1 0.0 0.012 15.2 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.4 001045509.1_39723001_1 - 0.014 14.4 0.0 0.03 13.4 0.0 1.5 1 0 0 1 1 1 0 Tubulin like Gly_acyl_tr_N PF06021.9 001013762.2_32924001_1 - 1.2e-86 289.8 0.2 1.6e-86 289.4 0.2 1.2 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase Gly_acyl_tr_C PF08444.8 001013762.2_32924001_1 - 4.5e-43 145.3 0.4 1.1e-42 144.0 0.4 1.7 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region IL12 PF03039.12 001112637.1_40422001_1 - 3.3e-117 389.4 6.3 3.8e-117 389.2 6.3 1.0 1 0 0 1 1 1 1 Interleukin-12 alpha subunit RGS PF00615.17 001082214.1_37922001_1 - 1.1e-36 125.6 4.5 1.7e-36 124.9 4.5 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain Guanylate_kin PF00625.19 001131538.1_43529001_3 - 7.2e-52 175.6 0.0 1.2e-51 174.9 0.0 1.4 1 0 0 1 1 1 1 Guanylate kinase L27_N PF09060.8 001131538.1_43529001_3 - 1.4e-22 79.4 3.1 3.7e-22 78.0 3.1 1.8 1 0 0 1 1 1 1 L27_N SH3_2 PF07653.15 001131538.1_43529001_3 - 5.9e-12 45.0 0.0 1.1e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain PDZ PF00595.22 001131538.1_43529001_3 - 3.8e-11 43.0 0.5 7.1e-11 42.2 0.5 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) L27 PF02828.14 001131538.1_43529001_3 - 1.4e-06 27.8 1.5 4.9e-06 26.1 1.5 1.9 1 0 0 1 1 1 1 L27 domain PDZ_2 PF13180.4 001131538.1_43529001_3 - 9.5e-06 25.7 0.1 2.2e-05 24.5 0.1 1.6 1 0 0 1 1 1 1 PDZ domain SH3_1 PF00018.26 001131538.1_43529001_3 - 9.8e-06 25.0 0.0 2.3e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 001131538.1_43529001_3 - 0.00079 19.1 0.1 0.0015 18.2 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain IL1 PF00340.17 001009465.2_39522001_3 - 2.8e-46 156.0 0.1 4.7e-46 155.3 0.1 1.4 1 0 0 1 1 1 1 Interleukin-1 / 18 IL1_propep PF02394.14 001009465.2_39522001_3 - 1.2e-35 122.5 1.2 5.2e-35 120.5 0.1 2.0 2 0 0 2 2 2 1 Interleukin-1 propeptide Methyltransf_2 PF00891.16 001032940.1_29623001_1 - 2.1e-92 308.3 0.0 2.8e-92 307.9 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Dimerisation2 PF16864.3 001032940.1_29623001_1 - 1.5e-34 117.7 2.6 2.6e-34 116.9 0.3 2.4 3 0 0 3 3 3 1 Dimerisation domain Methyltransf_25 PF13649.4 001032940.1_29623001_1 - 7.8e-07 29.6 0.0 1.5e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.10 001032940.1_29623001_1 - 6.2e-06 26.7 0.0 1.1e-05 25.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain LRR_8 PF13855.4 001048231.1_39525001_1 - 8.2e-41 137.5 61.2 1.4e-12 47.0 6.8 8.5 5 2 5 10 10 10 9 Leucine rich repeat TIR PF01582.18 001048231.1_39525001_1 - 2.5e-22 79.4 0.4 4.9e-22 78.4 0.4 1.5 1 0 0 1 1 1 1 TIR domain LRR_4 PF12799.5 001048231.1_39525001_1 - 2.3e-18 65.8 54.7 8.8e-05 22.6 3.7 9.4 7 2 3 10 10 10 8 Leucine Rich repeats (2 copies) TIR_2 PF13676.4 001048231.1_39525001_1 - 9.1e-10 38.7 0.1 2.6e-09 37.2 0.0 1.8 2 0 0 2 2 2 1 TIR domain LRR_5 PF13306.4 001048231.1_39525001_1 - 3e-07 30.3 6.4 8e-07 28.9 0.1 3.8 3 2 1 4 4 4 2 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001048231.1_39525001_1 - 5.2e-07 29.2 19.3 0.0013 18.1 0.3 4.9 2 2 3 5 5 5 3 Leucine-rich repeat LRR_6 PF13516.4 001048231.1_39525001_1 - 0.0022 17.8 32.7 0.33 11.0 0.0 9.0 10 0 0 10 10 10 3 Leucine Rich repeat LRRCT PF01463.22 001048231.1_39525001_1 - 0.0099 16.2 1.2 0.039 14.4 0.3 2.6 2 0 0 2 2 2 1 Leucine rich repeat C-terminal domain LRR_1 PF00560.31 001048231.1_39525001_1 - 0.011 15.9 41.7 0.1 13.0 1.0 11.2 11 2 0 11 11 11 0 Leucine Rich Repeat DUF3890 PF13029.4 001048231.1_39525001_1 - 1.9 8.9 12.8 8.6 6.8 0.2 4.8 4 1 0 4 4 4 0 Domain of unknown function (DUF3890) Filament PF00038.19 001110820.1_39724001_2 - 6.2e-107 357.6 39.4 7.3e-107 357.4 39.4 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.10 001110820.1_39724001_2 - 0.16 11.9 39.3 0.27 11.2 5.1 4.0 2 2 1 3 3 3 0 TPR/MLP1/MLP2-like protein zf-C4H2 PF10146.7 001110820.1_39724001_2 - 0.19 11.9 22.4 7 6.7 5.7 3.4 1 1 0 2 2 2 0 Zinc finger-containing protein Gp58 PF07902.9 001110820.1_39724001_2 - 0.39 9.0 10.3 0.61 8.3 10.3 1.4 1 0 0 1 1 1 0 gp58-like protein Baculo_PEP_C PF04513.10 001110820.1_39724001_2 - 1.4 8.8 21.3 2.9 7.8 2.1 3.4 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.10 001110820.1_39724001_2 - 3.7 7.4 17.7 3.4 7.5 1.1 3.7 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) NYD-SP28_assoc PF14775.4 001110820.1_39724001_2 - 3.9 7.5 16.4 1.6 8.7 1.2 4.2 3 1 0 3 3 3 0 Sperm tail C-terminal domain TNF PF00229.16 001082263.1_37924001_3 - 3.8e-40 136.6 0.0 7.2e-40 135.7 0.0 1.4 2 0 0 2 2 2 1 TNF(Tumour Necrosis Factor) family Thyroglobulin_1 PF00086.16 001009436.1_39523001_1 - 2.2e-17 62.3 2.5 3.5e-17 61.7 0.9 2.2 2 0 0 2 2 2 1 Thyroglobulin type-1 repeat IGFBP PF00219.16 001009436.1_39523001_1 - 4.8e-11 43.0 19.7 4.8e-11 43.0 19.7 2.6 2 0 0 2 2 2 1 Insulin-like growth factor binding protein TNF PF00229.16 001009835.1_22422001_1 - 8.4e-38 129.1 0.0 1.2e-37 128.5 0.0 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family Lipocalin PF00061.21 213796.1_49822001_1 - 2.5e-21 76.3 1.0 2.8e-21 76.1 1.0 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family DUF4988 PF16378.3 213796.1_49822001_1 - 0.042 13.3 1.6 0.058 12.8 0.6 1.6 1 1 0 2 2 2 0 Domain of unknown function 7tm_1 PF00001.19 001099968.1_37923001_2 - 1.9e-50 171.5 10.8 2.4e-50 171.1 10.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 001099968.1_37923001_2 - 9.2e-12 44.7 7.6 2.3e-11 43.5 7.6 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.7 001099968.1_37923001_2 - 4.9e-07 29.3 6.0 7.8e-07 28.6 5.8 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.7 001099968.1_37923001_2 - 9.4e-07 28.3 11.9 1.4e-06 27.8 11.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001099968.1_37923001_2 - 8.2e-05 22.3 9.8 0.0011 18.6 4.8 2.4 2 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001099968.1_37923001_2 - 0.00054 19.2 6.6 0.00054 19.2 6.6 2.2 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Frag1 PF10277.7 001099968.1_37923001_2 - 0.0074 15.7 3.8 0.0074 15.7 3.8 2.5 2 1 0 2 2 2 1 Frag1/DRAM/Sfk1 family Thioredoxin PF00085.18 001009421.1_39522001_2 - 5.4e-32 109.7 1.7 6.4e-32 109.5 1.7 1.1 1 0 0 1 1 1 1 Thioredoxin DIM1 PF02966.14 001009421.1_39522001_2 - 1.2e-05 25.0 0.1 1.5e-05 24.6 0.1 1.1 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin_8 PF13905.4 001009421.1_39522001_2 - 4.3e-05 23.6 0.2 9.1e-05 22.6 0.2 1.6 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.4 001009421.1_39522001_2 - 0.0005 20.4 0.2 0.0031 17.8 0.2 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.4 001009421.1_39522001_2 - 0.00057 19.9 0.3 0.00088 19.3 0.3 1.3 1 0 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.11 001009421.1_39522001_2 - 0.00059 19.1 0.6 0.00071 18.9 0.6 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_9 PF14595.4 001009421.1_39522001_2 - 0.0011 18.6 0.0 0.0013 18.3 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Glutaredoxin PF00462.22 001009421.1_39522001_2 - 0.0044 17.1 0.7 0.0079 16.3 0.7 1.4 1 0 0 1 1 1 1 Glutaredoxin AhpC-TSA PF00578.19 001009421.1_39522001_2 - 0.0056 16.5 0.3 0.0076 16.0 0.3 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.8 001009421.1_39522001_2 - 0.05 13.1 0.1 0.06 12.9 0.1 1.2 1 0 0 1 1 1 0 Redoxin Ribosomal_L16 PF00252.16 001132532.1_43522001_2 - 2e-44 150.7 0.3 2.4e-44 150.4 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e TIM PF00121.16 001132533.1_43523001_2 - 1.5e-85 286.3 0.0 1.8e-85 286.1 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase RNA_pol_Rpa2_4 PF06883.10 001132533.1_43523001_2 - 0.065 13.1 0.0 2.5 8.0 0.0 2.4 2 0 0 2 2 2 0 RNA polymerase I, Rpa2 specific domain Cys_knot PF00007.20 214080.1_49821001_1 - 7.6e-32 109.6 2.3 8.6e-32 109.4 2.3 1.0 1 0 0 1 1 1 1 Cystine-knot domain Pkinase PF00069.23 001132454.1_43529001_1 - 1.3e-17 63.9 0.0 2.3e-16 59.8 0.0 2.5 1 1 0 1 1 1 1 Protein kinase domain WD40 PF00400.30 001132454.1_43529001_1 - 4.8e-10 39.7 15.0 0.0055 17.4 0.1 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat HEAT PF02985.20 001132454.1_43529001_1 - 1.7e-07 30.7 1.8 0.4 10.9 0.0 5.1 5 0 0 5 5 5 3 HEAT repeat Pkinase_Tyr PF07714.15 001132454.1_43529001_1 - 0.00016 21.0 0.0 0.0015 17.8 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase ANAPC4_WD40 PF12894.5 001132454.1_43529001_1 - 0.00031 20.9 0.1 0.26 11.5 0.0 4.2 1 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain HEAT_2 PF13646.4 001132454.1_43529001_1 - 0.045 14.0 0.1 0.79 10.0 0.2 2.8 2 1 1 3 3 3 0 HEAT repeats Cpn60_TCP1 PF00118.22 001032972.2_32324001_3 - 6.7e-155 516.3 13.2 7.7e-155 516.1 13.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ig_2 PF13895.4 001009027.1_39725001_1 - 8.3e-32 109.2 0.4 5.7e-14 52.1 0.0 4.7 5 0 0 5 5 5 4 Immunoglobulin domain Ig_3 PF13927.4 001009027.1_39725001_1 - 1.8e-19 70.0 0.3 2.7e-05 24.6 0.0 4.5 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.23 001009027.1_39725001_1 - 7.7e-15 54.7 0.0 0.00048 20.1 0.0 4.4 4 0 0 4 4 4 3 Immunoglobulin domain SIT PF15330.4 001009027.1_39725001_1 - 0.12 12.6 0.4 2.5 8.4 0.0 2.3 1 1 2 3 3 3 0 SHP2-interacting transmembrane adaptor protein, SIT I-set PF07679.14 001009027.1_39725001_1 - 0.2 11.6 0.0 19 5.3 0.0 3.4 4 0 0 4 4 4 0 Immunoglobulin I-set domain ADH_N_2 PF16884.3 001082702.1_37924001_3 - 2.4e-38 130.2 0.0 4.3e-38 129.4 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.24 001082702.1_37924001_3 - 4.1e-26 91.3 0.0 6.4e-26 90.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.4 001082702.1_37924001_3 - 1.8e-08 35.3 0.0 3.9e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF3197 PF11432.6 001082702.1_37924001_3 - 0.18 11.6 0.0 0.41 10.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3197) Trypsin PF00089.24 001122985.1_49825001_2 - 2.9e-66 223.3 0.0 4.2e-66 222.8 0.0 1.3 1 0 0 1 1 1 1 Trypsin Kringle PF00051.16 001122985.1_49825001_2 - 1.1e-49 166.5 9.3 5.8e-26 90.5 1.6 2.5 2 0 0 2 2 2 2 Kringle domain Thrombin_light PF09396.8 001122985.1_49825001_2 - 5.4e-25 86.8 2.6 1.2e-24 85.7 2.6 1.6 1 0 0 1 1 1 1 Thrombin light chain Gla PF00594.18 001122985.1_49825001_2 - 1.1e-17 63.8 7.6 1.1e-17 63.8 7.6 1.9 2 0 0 2 2 2 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain DUF1986 PF09342.9 001122985.1_49825001_2 - 0.0006 20.0 0.0 0.0012 19.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 001122985.1_49825001_2 - 0.0064 17.2 0.0 0.017 15.9 0.0 1.8 1 1 0 1 1 1 1 Trypsin-like peptidase domain WD40 PF00400.30 001133784.1_43528001_3 - 2.6e-09 37.4 0.9 0.027 15.2 0.1 4.8 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001133784.1_43528001_3 - 0.029 14.5 0.0 5.4 7.3 0.0 2.9 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain IL2 PF00715.15 001112654.1_40421001_1 - 3.1e-80 267.1 6.0 3.5e-80 266.9 6.0 1.0 1 0 0 1 1 1 1 Interleukin 2 Plasmid_RAQPRD PF09686.8 001112654.1_40421001_1 - 0.0034 17.4 0.1 0.027 14.5 0.0 2.0 2 0 0 2 2 2 1 Plasmid protein of unknown function (Plasmid_RAQPRD) CASP_C PF08172.10 001044377.1_39722001_1 - 0.04 13.1 0.2 0.057 12.6 0.2 1.2 1 0 0 1 1 1 0 CASP C terminal JAKMIP_CC3 PF16034.3 001044377.1_39722001_1 - 0.23 11.2 3.0 0.096 12.5 0.5 1.7 2 0 0 2 2 2 0 JAKMIP CC3 domain CFTR_R PF14396.4 001079917.1_39729001_1 - 1.8e-101 338.0 2.3 2.9e-101 337.3 2.3 1.3 1 0 0 1 1 1 1 Cystic fibrosis TM conductance regulator (CFTR), regulator domain ABC_membrane PF00664.21 001079917.1_39729001_1 - 1.1e-91 307.2 42.3 1.1e-49 169.5 20.7 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 001079917.1_39729001_1 - 5e-59 198.6 0.2 5.6e-33 114.2 0.0 3.0 3 0 0 3 3 2 2 ABC transporter AAA_21 PF13304.4 001079917.1_39729001_1 - 3.8e-07 30.1 1.3 0.035 13.8 0.1 3.3 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.17 001079917.1_39729001_1 - 4.7e-07 29.3 0.0 0.031 13.6 0.0 3.4 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.4 001079917.1_39729001_1 - 1e-05 25.0 3.7 0.00097 18.7 0.0 3.2 3 0 0 3 3 3 1 P-loop containing region of AAA domain T2SSE PF00437.18 001079917.1_39729001_1 - 1.1e-05 24.5 0.2 0.052 12.5 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein DUF258 PF03193.14 001079917.1_39729001_1 - 4e-05 23.4 1.1 0.039 13.7 0.1 2.7 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.4 001079917.1_39729001_1 - 0.00012 22.3 0.0 0.37 11.0 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.15 001079917.1_39729001_1 - 0.00016 21.7 0.6 0.083 12.8 0.1 2.8 2 0 0 2 2 2 1 Domain of unknown function DUF87 Zeta_toxin PF06414.10 001079917.1_39729001_1 - 0.00096 18.4 0.5 0.19 10.9 0.1 2.6 2 0 0 2 2 2 1 Zeta toxin MMR_HSR1 PF01926.21 001079917.1_39729001_1 - 0.0015 18.4 0.0 0.32 11.0 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase NACHT PF05729.10 001079917.1_39729001_1 - 0.0018 18.1 0.8 1.9 8.2 0.1 2.7 2 0 0 2 2 2 2 NACHT domain ArgK PF03308.14 001079917.1_39729001_1 - 0.0019 17.1 0.8 0.015 14.1 0.1 2.1 2 0 0 2 2 2 1 ArgK protein AAA_22 PF13401.4 001079917.1_39729001_1 - 0.0041 17.3 0.3 3.7 7.7 0.0 3.0 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.13 001079917.1_39729001_1 - 0.012 15.4 0.3 0.38 10.5 0.0 2.6 3 0 0 3 3 2 0 NTPase Roc PF08477.11 001079917.1_39729001_1 - 0.019 15.1 0.2 4.8 7.3 0.0 3.4 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_19 PF13245.4 001079917.1_39729001_1 - 0.023 14.9 0.0 19 5.4 0.0 3.1 2 1 0 2 2 2 0 AAA domain AAA_30 PF13604.4 001079917.1_39729001_1 - 0.027 14.1 0.0 1 8.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain TsaE PF02367.15 001079917.1_39729001_1 - 0.051 13.5 0.6 14 5.6 0.1 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MobB PF03205.12 001079917.1_39729001_1 - 0.067 13.0 1.2 16 5.3 0.1 3.1 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B FtsK_SpoIIIE PF01580.16 001079917.1_39729001_1 - 0.071 12.3 0.6 6 6.0 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family cobW PF02492.17 001079917.1_39729001_1 - 0.1 12.1 1.8 5.9 6.3 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.4 001079917.1_39729001_1 - 0.45 10.9 13.5 1.2 9.5 0.0 4.0 4 0 0 4 4 4 0 AAA domain AAA_15 PF13175.4 001079917.1_39729001_1 - 7.4 5.9 8.0 16 4.8 0.0 3.7 4 1 0 4 4 3 0 AAA ATPase domain Agouti PF05039.10 001164331.1_40421001_1 - 4.4e-30 104.1 15.7 5.6e-30 103.8 15.7 1.1 1 0 0 1 1 1 1 Agouti protein Toxin_9 PF02819.13 001164331.1_40421001_1 - 0.15 12.2 16.0 0.22 11.7 16.0 1.3 1 0 0 1 1 1 0 Spider toxin UPF0542 PF15086.4 001164331.1_40421001_1 - 1 9.2 4.1 0.69 9.8 2.0 1.7 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 HLH PF00010.24 001012432.1_39723001_1 - 3.3e-17 62.0 0.7 5.9e-17 61.3 0.7 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Dishevelled PF02377.13 001012432.1_39723001_2 - 1.3 9.3 8.0 2.7 8.3 8.0 1.5 1 0 0 1 1 1 0 Dishevelled specific domain IL8 PF00048.18 001009358.1_39521001_3 - 2.4e-14 53.1 0.5 2.9e-14 52.8 0.5 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like MBD_C PF14048.4 001009358.1_39521001_3 - 0.097 13.3 0.3 0.13 12.8 0.3 1.2 1 0 0 1 1 1 0 C-terminal domain of methyl-CpG binding protein 2 and 3 PI3K_1B_p101 PF10486.7 213851.1_49829001_3 - 0 1262.4 0.0 0 1262.1 0.0 1.0 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit An_peroxidase PF03098.13 214096.2_49829001_1 - 3.5e-136 454.7 0.0 4.7e-136 454.3 0.0 1.2 1 0 0 1 1 1 1 Animal haem peroxidase NAD_binding_6 PF08030.10 214096.2_49829001_1 - 3.9e-30 104.9 0.0 7e-30 104.1 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.10 214096.2_49829001_1 - 1.3e-18 67.0 0.0 3e-18 65.8 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.17 214096.2_49829001_1 - 8.2e-18 64.6 15.4 8.2e-18 64.6 15.4 2.7 3 0 0 3 3 3 1 Ferric reductase like transmembrane component EF-hand_1 PF00036.30 214096.2_49829001_1 - 7.5e-13 46.9 10.6 1.7e-06 27.0 0.7 3.1 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.4 214096.2_49829001_1 - 8.8e-13 47.7 7.1 5.9e-05 22.6 0.1 3.5 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.4 214096.2_49829001_1 - 9.3e-13 48.3 5.7 3.8e-07 30.4 1.6 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 214096.2_49829001_1 - 6.4e-11 41.1 6.3 1.9e-05 24.1 0.2 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.4 214096.2_49829001_1 - 2e-07 30.1 2.8 0.0065 15.8 0.3 2.8 2 0 0 2 2 2 2 EF hand NAD_binding_1 PF00175.19 214096.2_49829001_1 - 0.0015 19.0 0.0 0.04 14.4 0.0 2.4 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain ThiF PF00899.19 001101819.1_49825001_3 - 2.1e-63 213.8 0.0 3e-63 213.3 0.0 1.1 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.18 001101819.1_49825001_3 - 1.4e-10 41.5 0.0 2.1e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain Shikimate_DH PF01488.18 001101819.1_49825001_3 - 0.16 11.9 0.0 0.29 11.1 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase IL8 PF00048.18 001082342.1_37923001_3 - 1.3e-13 50.7 0.9 2.2e-13 50.0 0.9 1.3 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like GHBP PF12772.5 001112616.1_40425001_1 - 7.1e-128 426.2 3.9 9.2e-128 425.8 3.9 1.1 1 0 0 1 1 1 1 Growth hormone receptor binding EpoR_lig-bind PF09067.8 001112616.1_40425001_1 - 2.7e-10 40.3 2.8 2.7e-10 40.3 2.8 2.0 2 0 0 2 2 2 1 Erythropoietin receptor, ligand binding fn3 PF00041.19 001112616.1_40425001_1 - 4.1e-06 26.9 0.1 8.6e-06 25.9 0.1 1.6 1 0 0 1 1 1 1 Fibronectin type III domain AA_permease PF00324.19 001082123.1_37929001_2 - 2.2e-60 204.5 30.7 1.2e-38 132.9 6.6 2.1 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.13 001082123.1_37929001_2 - 2.1e-47 161.9 2.5 2.6e-30 105.7 1.5 3.1 1 1 1 2 2 2 2 Solute carrier family 12 CFTR_R PF14396.4 001168545.1_43529001_1 - 9.2e-100 332.4 1.8 1.4e-99 331.8 1.8 1.3 1 0 0 1 1 1 1 Cystic fibrosis TM conductance regulator (CFTR), regulator domain ABC_membrane PF00664.21 001168545.1_43529001_1 - 5.4e-92 308.2 42.4 6.1e-50 170.3 21.1 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 001168545.1_43529001_1 - 7e-59 198.1 0.0 5.6e-33 114.2 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 001168545.1_43529001_1 - 3.9e-07 29.6 0.0 0.023 14.0 0.0 3.3 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.4 001168545.1_43529001_1 - 4.3e-07 29.9 1.2 0.034 13.8 0.1 3.3 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 001168545.1_43529001_1 - 9.6e-06 25.1 3.2 0.00097 18.7 0.0 3.0 3 0 0 3 3 3 1 P-loop containing region of AAA domain T2SSE PF00437.18 001168545.1_43529001_1 - 1.1e-05 24.6 0.1 0.051 12.5 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein DUF258 PF03193.14 001168545.1_43529001_1 - 3e-05 23.8 0.6 0.04 13.7 0.1 2.6 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.4 001168545.1_43529001_1 - 0.00014 22.2 0.0 0.37 11.0 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.15 001168545.1_43529001_1 - 0.00017 21.6 0.6 0.083 12.8 0.1 2.7 2 0 0 2 2 2 1 Domain of unknown function DUF87 Zeta_toxin PF06414.10 001168545.1_43529001_1 - 0.00097 18.4 0.5 0.19 10.9 0.1 2.6 2 0 0 2 2 2 1 Zeta toxin MMR_HSR1 PF01926.21 001168545.1_43529001_1 - 0.0016 18.4 0.0 0.32 11.0 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase ArgK PF03308.14 001168545.1_43529001_1 - 0.0017 17.3 0.8 0.015 14.1 0.1 2.3 2 0 0 2 2 2 1 ArgK protein NACHT PF05729.10 001168545.1_43529001_1 - 0.002 17.9 0.8 1.9 8.2 0.1 2.6 2 0 0 2 2 2 2 NACHT domain AAA_22 PF13401.4 001168545.1_43529001_1 - 0.0065 16.6 1.0 3.7 7.7 0.0 3.0 3 0 0 3 3 2 1 AAA domain NTPase_1 PF03266.13 001168545.1_43529001_1 - 0.013 15.3 0.3 0.38 10.5 0.0 2.6 3 0 0 3 3 2 0 NTPase Roc PF08477.11 001168545.1_43529001_1 - 0.014 15.5 0.1 4.8 7.3 0.0 3.4 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_30 PF13604.4 001168545.1_43529001_1 - 0.027 14.0 0.0 1 8.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.4 001168545.1_43529001_1 - 0.034 14.3 0.1 19 5.4 0.0 3.0 2 1 0 2 2 2 0 AAA domain TsaE PF02367.15 001168545.1_43529001_1 - 0.051 13.5 0.6 14 5.6 0.1 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE FtsK_SpoIIIE PF01580.16 001168545.1_43529001_1 - 0.068 12.4 0.5 6 6.0 0.1 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family MobB PF03205.12 001168545.1_43529001_1 - 0.074 12.8 1.3 16 5.3 0.1 3.0 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B NB-ARC PF00931.20 001168545.1_43529001_1 - 0.077 11.9 0.1 1.5 7.6 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain cobW PF02492.17 001168545.1_43529001_1 - 0.1 12.0 1.8 5.9 6.3 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.4 001168545.1_43529001_1 - 0.57 10.5 13.1 1.2 9.5 0.0 3.8 4 0 0 4 4 4 0 AAA domain Serpin PF00079.18 001100920.2_39523001_1 - 1.8e-106 356.5 0.9 2.1e-106 356.2 0.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) LRRNT PF01462.16 001100920.2_39523001_2 - 3.5 7.2 8.3 22 4.7 0.0 3.8 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain DDE_1 PF03184.17 001126268.2_45726001_1 - 4.8e-20 71.7 0.0 5.6e-14 52.0 0.0 2.3 2 0 0 2 2 2 2 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.14 001126268.2_45726001_1 - 3.1e-17 62.2 0.3 7e-17 61.1 0.3 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.11 001126268.2_45726001_1 - 1.5e-07 30.8 0.0 2.8e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_28 PF13518.4 001126268.2_45726001_1 - 0.00049 20.0 0.0 0.0042 17.1 0.0 2.5 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_1 PF01527.18 001126268.2_45726001_1 - 0.00082 19.5 0.0 0.0022 18.2 0.0 1.8 1 0 0 1 1 1 1 Transposase CoA_binding PF02629.17 214409.2_49823001_3 - 9.5e-33 112.6 0.4 2e-32 111.6 0.4 1.6 1 0 0 1 1 1 1 CoA binding domain Ligase_CoA PF00549.17 214409.2_49823001_3 - 1.3e-23 83.4 0.1 2.4e-23 82.5 0.1 1.4 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.4 214409.2_49823001_3 - 5.1e-08 32.7 0.0 1.2e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.4 214409.2_49823001_3 - 0.00022 21.6 0.0 0.00046 20.5 0.0 1.5 1 0 0 1 1 1 1 CoA binding domain Thioredoxin PF00085.18 001024998.1_45724001_1 - 1.2e-08 34.7 0.0 2.2e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Sushi PF00084.18 001009355.1_22423001_3 - 6.2e-06 26.6 13.6 0.0043 17.5 2.7 2.8 3 0 0 3 3 3 2 Sushi repeat (SCR repeat) Sugar_tr PF00083.22 001082022.1_37926001_2 - 5.8e-29 101.1 15.1 5.8e-29 101.1 15.1 2.1 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.14 001082022.1_37926001_2 - 2.1e-26 92.6 29.5 2.2e-19 69.5 9.3 2.6 2 1 1 3 3 3 2 Major Facilitator Superfamily DUF758 PF05527.9 001168944.1_40422001_1 - 4.7e-74 248.2 0.0 5.3e-74 248.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF758) MoaE PF02391.15 001168944.1_40422001_1 - 0.019 15.1 0.0 0.034 14.3 0.0 1.4 1 0 0 1 1 1 0 MoaE protein LRR_8 PF13855.4 001009218.1_39523001_3 - 9.8e-42 140.4 20.5 5.9e-16 57.8 2.8 4.4 3 2 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.5 001009218.1_39523001_3 - 3e-23 81.3 21.9 2.2e-05 24.6 2.2 5.9 2 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001009218.1_39523001_3 - 7.4e-12 45.2 0.7 7.2e-05 22.6 0.2 3.1 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001009218.1_39523001_3 - 3.5e-11 42.8 6.4 1.4e-05 24.6 3.1 3.1 1 1 2 3 3 3 3 Leucine-rich repeat LRRNT PF01462.16 001009218.1_39523001_3 - 7.7e-10 38.1 5.2 7.7e-10 38.1 5.2 2.3 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.31 001009218.1_39523001_3 - 0.0001 22.1 11.0 15 6.4 0.1 7.3 7 1 0 7 7 7 1 Leucine Rich Repeat LRR_6 PF13516.4 001009218.1_39523001_3 - 0.0025 17.6 17.3 0.36 10.9 0.0 6.9 7 0 0 7 7 7 2 Leucine Rich repeat STAR_dimer PF16544.3 001009218.1_39523001_3 - 0.08 12.4 0.2 0.19 11.2 0.2 1.6 1 0 0 1 1 1 0 Homodimerisation region of STAR domain protein Defensin_beta_2 PF13841.4 001129761.1_39721001_1 - 1.6e-05 25.1 6.8 1.6e-05 25.1 6.8 1.7 2 0 0 2 2 2 1 Beta defensin Defensin_beta PF00711.17 001129761.1_39721001_1 - 0.042 13.8 6.6 0.086 12.8 6.6 1.5 1 0 0 1 1 1 0 Beta defensin Sushi PF00084.18 001035520.1_39722001_1 - 8.8e-07 29.3 10.2 0.0033 17.9 1.6 2.4 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) Defensin_beta_2 PF13841.4 001129779.1_39721001_1 - 8.1e-07 29.3 8.6 1.1e-06 28.9 8.6 1.2 1 0 0 1 1 1 1 Beta defensin Histone PF00125.22 001170941.1_37922001_1 - 2.8e-18 66.5 0.0 3.9e-18 66.0 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.3 001170941.1_37922001_1 - 1.4e-09 37.4 0.2 1.4e-09 37.4 0.2 1.9 2 0 0 2 2 2 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.21 001170941.1_37922001_1 - 0.033 14.3 0.0 0.059 13.5 0.0 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone WD40 PF00400.30 001131488.1_43524001_3 - 5.6e-36 121.8 21.6 1.6e-06 28.6 0.2 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001131488.1_43524001_3 - 3.2e-12 46.4 0.1 0.2 11.8 0.0 5.3 1 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 001131488.1_43524001_3 - 0.00011 21.5 0.1 0.85 8.7 0.0 3.8 2 1 2 4 4 4 2 WD40-like domain 7tm_1 PF00001.19 001009407.1_39524001_3 - 7e-50 169.6 24.4 9.4e-50 169.2 24.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001009407.1_39524001_3 - 3.1e-10 39.8 22.9 5.2e-10 39.0 22.9 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001009407.1_39524001_3 - 5.6e-05 22.9 18.7 5.7e-05 22.9 12.1 2.2 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001009407.1_39524001_3 - 6.4e-05 22.3 15.5 6.4e-05 22.3 15.5 2.4 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx ISK_Channel PF02060.13 001009407.1_39524001_3 - 0.16 11.5 5.1 4.2 7.0 0.0 3.8 4 1 1 5 5 5 0 Slow voltage-gated potassium channel PRY PF13765.4 001045508.1_39723001_1 - 7.8e-20 70.1 0.5 1.8e-19 68.9 0.1 1.9 2 0 0 2 2 1 1 SPRY-associated domain SPRY PF00622.26 001045508.1_39723001_1 - 4.9e-12 45.9 0.0 9.8e-12 44.9 0.0 1.5 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.22 001045508.1_39723001_1 - 3e-08 33.5 1.2 3e-08 33.5 1.2 3.5 4 0 0 4 4 3 1 B-box zinc finger zf-C3HC4 PF00097.23 001045508.1_39723001_1 - 9.3e-07 28.5 3.7 2.4e-06 27.2 3.7 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001045508.1_39723001_1 - 3.9e-06 26.8 6.2 3.9e-06 26.8 6.2 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.4 001045508.1_39723001_1 - 4.4e-06 26.5 1.5 4.4e-06 26.5 1.5 2.7 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 001045508.1_39723001_1 - 7.9e-06 25.5 6.4 3.7e-05 23.3 6.5 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 001045508.1_39723001_1 - 8.1e-06 25.5 4.4 8.1e-06 25.5 4.4 2.0 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.4 001045508.1_39723001_1 - 1.4e-05 24.7 3.3 1.4e-05 24.7 3.3 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001045508.1_39723001_1 - 1.5e-05 25.0 4.8 1.5e-05 25.0 4.8 2.1 2 0 0 2 2 1 1 Ring finger domain zf-RING_5 PF14634.4 001045508.1_39723001_1 - 0.00029 20.6 4.0 0.00029 20.6 4.0 2.4 2 0 0 2 2 2 1 zinc-RING finger domain Fib_alpha PF08702.8 001045508.1_39723001_1 - 0.013 15.5 7.1 0.029 14.4 7.1 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF3584 PF12128.6 001045508.1_39723001_1 - 0.014 12.8 8.1 0.018 12.5 8.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4618 PF15397.4 001045508.1_39723001_1 - 0.02 14.2 14.3 0.031 13.6 14.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) AAA_13 PF13166.4 001045508.1_39723001_1 - 0.058 11.9 4.5 0.079 11.5 4.5 1.1 1 0 0 1 1 1 0 AAA domain Lipoprotein_7 PF01540.14 001045508.1_39723001_1 - 0.06 12.5 1.4 0.084 12.0 1.4 1.1 1 0 0 1 1 1 0 Adhesin lipoprotein Exonuc_VII_L PF02601.13 001045508.1_39723001_1 - 0.1 12.0 3.3 0.13 11.6 3.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Spc7 PF08317.9 001045508.1_39723001_1 - 0.15 10.7 10.6 0.27 10.0 10.6 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein CorA PF01544.16 001045508.1_39723001_1 - 0.17 11.0 4.7 0.29 10.3 4.7 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF1664 PF07889.10 001045508.1_39723001_1 - 0.22 11.4 6.4 1.4 8.8 4.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF2203 PF09969.7 001045508.1_39723001_1 - 0.33 11.5 4.7 0.63 10.6 3.9 1.8 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Prominin PF05478.9 001045508.1_39723001_1 - 0.4 8.4 3.8 0.58 7.9 3.8 1.1 1 0 0 1 1 1 0 Prominin CREPT PF16566.3 001045508.1_39723001_1 - 0.49 10.4 9.3 1.1 9.3 9.3 1.5 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour DNA_topoisoIV PF00521.18 001045508.1_39723001_1 - 0.64 8.7 4.4 0.94 8.1 4.4 1.1 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A Apolipoprotein PF01442.16 001045508.1_39723001_1 - 1.6 8.5 13.9 6.1 6.6 13.8 1.8 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain SpecificRecomb PF10136.7 001045508.1_39723001_1 - 2.2 6.3 3.9 3 5.9 3.9 1.1 1 0 0 1 1 1 0 Site-specific recombinase DUF745 PF05335.11 001045508.1_39723001_1 - 2.4 7.7 5.0 2.5 7.6 4.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF745) GvpL_GvpF PF06386.9 001045508.1_39723001_1 - 2.4 7.9 8.4 3.7 7.3 8.4 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF DUF342 PF03961.11 001045508.1_39723001_1 - 3.3 6.1 4.5 4.5 5.6 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF1640 PF07798.9 001045508.1_39723001_1 - 3.4 7.6 10.8 5.7 6.8 3.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) Remorin_C PF03763.11 001045508.1_39723001_1 - 7 6.5 7.5 76 3.2 7.5 2.1 1 1 0 1 1 1 0 Remorin, C-terminal region DUF16 PF01519.14 001045508.1_39723001_1 - 8.3 6.8 11.3 1.5e+02 2.8 11.4 2.3 1 1 0 1 1 1 0 Protein of unknown function DUF16 T4_deiodinase PF00837.15 001122650.1_39522001_1 - 2.4e-119 396.7 0.0 2.8e-119 396.5 0.0 1.0 1 0 0 1 1 1 1 Iodothyronine deiodinase TNF PF00229.16 001045511.1_39722001_1 - 1.2e-40 138.2 0.0 1.6e-40 137.8 0.0 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family IL1_propep PF02394.14 001009351.1_22422001_1 - 2.7e-38 131.1 2.2 6.3e-38 129.9 2.2 1.6 1 0 0 1 1 1 1 Interleukin-1 propeptide IL1 PF00340.17 001009351.1_22422001_1 - 1.9e-37 127.4 0.0 3.7e-37 126.5 0.0 1.5 1 0 0 1 1 1 1 Interleukin-1 / 18 TRIC PF05197.11 001099969.1_37922001_1 - 6.5e-82 273.6 5.6 8.6e-82 273.2 5.6 1.2 1 0 0 1 1 1 1 TRIC channel IL12 PF03039.12 001009736.1_39522001_1 - 5.3e-113 375.6 6.9 6e-113 375.4 6.9 1.0 1 0 0 1 1 1 1 Interleukin-12 alpha subunit Mob1_phocein PF03637.15 001133180.1_43527001_2 - 8.6e-81 269.8 0.0 1.4e-80 269.1 0.0 1.3 1 0 0 1 1 1 1 Mob1/phocein family WD40 PF00400.30 001034091.1_39723001_1 - 1.8e-62 205.6 17.3 9.9e-09 35.6 0.3 7.7 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001034091.1_39723001_1 - 1.6e-16 60.2 2.8 0.054 13.7 0.0 5.9 2 2 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 001034091.1_39723001_1 - 6.2e-13 48.1 9.9 0.0087 14.6 0.0 6.0 2 2 3 6 6 6 4 Nucleoporin Nup120/160 LisH PF08513.9 001034091.1_39723001_1 - 6.1e-09 35.4 0.4 1.6e-08 34.1 0.4 1.8 1 0 0 1 1 1 1 LisH Nucleoporin_N PF08801.9 001034091.1_39723001_1 - 8.8e-05 21.3 2.3 0.42 9.2 0.0 4.2 1 1 3 4 4 4 2 Nup133 N terminal like Ge1_WD40 PF16529.3 001034091.1_39723001_1 - 0.00023 20.1 7.9 0.88 8.3 0.2 4.8 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Pox_A_type_inc PF04508.10 001034091.1_39723001_1 - 0.0015 18.2 0.1 0.0034 17.0 0.1 1.6 1 0 0 1 1 1 1 Viral A-type inclusion protein repeat LisH_2 PF16045.3 001034091.1_39723001_1 - 0.014 14.3 0.0 0.026 13.4 0.0 1.4 1 0 0 1 1 1 0 LisH PET PF06297.12 001171041.1_37926001_2 - 8e-41 138.1 3.0 1.5e-40 137.3 3.0 1.5 1 0 0 1 1 1 1 PET Domain LIM PF00412.20 001171041.1_37926001_2 - 4.8e-26 90.6 57.9 8e-14 51.5 8.4 4.2 4 1 1 5 5 5 3 LIM domain Ig_Tie2_1 PF10430.7 001171041.1_37926001_2 - 0.075 13.3 0.0 0.21 11.9 0.0 1.7 1 0 0 1 1 1 0 Tie-2 Ig-like domain 1 Lipase PF00151.17 001082032.1_37924001_1 - 8.2e-138 459.2 0.0 1.2e-137 458.6 0.0 1.2 1 0 0 1 1 1 1 Lipase PLAT PF01477.21 001082032.1_37924001_1 - 3.3e-22 79.1 0.2 5.4e-22 78.4 0.2 1.3 1 0 0 1 1 1 1 PLAT/LH2 domain Abhydrolase_6 PF12697.5 001082032.1_37924001_1 - 0.0037 17.8 3.0 0.0052 17.3 3.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF726 PF05277.10 001082032.1_37924001_1 - 0.14 10.9 0.1 0.22 10.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF726) Syncollin PF15138.4 139086.1_45721001_1 - 1.5e-56 189.3 0.3 1.9e-56 188.9 0.3 1.1 1 0 0 1 1 1 1 Syncollin ABC_membrane PF00664.21 001082044.1_37929001_1 - 8.7e-69 232.1 29.9 6.7e-37 127.5 6.8 2.7 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 001082044.1_37929001_1 - 2e-49 167.5 0.8 2.9e-24 86.0 0.0 3.1 4 0 0 4 4 3 2 ABC transporter AAA_21 PF13304.4 001082044.1_37929001_1 - 1.8e-05 24.6 0.5 0.69 9.5 0.0 3.6 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF258 PF03193.14 001082044.1_37929001_1 - 0.0001 22.1 0.1 0.047 13.5 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 SMC_N PF02463.17 001082044.1_37929001_1 - 0.00012 21.4 8.7 0.15 11.3 0.1 4.2 3 2 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.4 001082044.1_37929001_1 - 0.00035 20.1 1.0 0.21 11.2 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.21 001082044.1_37929001_1 - 0.0021 18.0 0.1 1.4 8.9 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase IstB_IS21 PF01695.15 001082044.1_37929001_1 - 0.012 15.3 0.1 6.3 6.4 0.0 3.1 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_25 PF13481.4 001082044.1_37929001_1 - 0.018 14.5 0.0 0.4 10.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.4 001082044.1_37929001_1 - 0.021 15.0 0.2 5.4 7.2 0.0 2.7 3 0 0 3 3 2 0 AAA domain Zeta_toxin PF06414.10 001082044.1_37929001_1 - 0.039 13.1 0.0 0.59 9.3 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin AAA_16 PF13191.4 001082044.1_37929001_1 - 0.079 13.2 0.4 1.1 9.5 0.1 2.5 2 1 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.4 001082044.1_37929001_1 - 0.27 11.6 11.7 17 5.7 0.1 2.9 2 1 0 2 2 2 0 AAA domain Dynamin_N PF00350.21 001082044.1_37929001_1 - 1.7 8.6 3.2 2.6 7.9 0.1 2.5 2 0 0 2 2 2 0 Dynamin family OATP PF03137.18 177481.1_45725001_1 - 5.3e-180 599.2 9.7 6.3e-180 598.9 9.7 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 177481.1_45725001_1 - 2e-26 92.6 12.2 2e-26 92.6 12.2 2.9 2 2 0 2 2 2 1 Major Facilitator Superfamily Kazal_2 PF07648.13 177481.1_45725001_1 - 2.2e-05 24.4 9.2 4.2e-05 23.5 5.3 2.6 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain MFS_1_like PF12832.5 177481.1_45725001_1 - 0.0086 14.8 3.7 0.016 13.9 0.8 2.5 2 1 1 3 3 3 1 MFS_1 like family Kazal_1 PF00050.19 177481.1_45725001_1 - 0.021 14.7 9.0 0.099 12.5 9.0 2.2 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain PUCC PF03209.13 177481.1_45725001_1 - 0.64 8.8 14.7 0.26 10.1 0.1 3.9 4 0 0 4 4 4 0 PUCC protein IL2 PF00715.15 001009806.1_39522001_1 - 4.2e-70 234.2 4.4 4.9e-70 234.0 4.4 1.0 1 0 0 1 1 1 1 Interleukin 2 PET PF06297.12 001168698.1_22426001_1 - 8.1e-41 138.1 3.0 1.5e-40 137.3 3.0 1.4 1 0 0 1 1 1 1 PET Domain LIM PF00412.20 001168698.1_22426001_1 - 2.3e-27 94.8 58.6 7.9e-14 51.5 8.4 4.6 4 1 1 5 5 5 3 LIM domain NCD3G PF07562.12 001168698.1_22426001_1 - 0.0096 15.8 1.7 0.0096 15.8 1.7 4.8 5 0 0 5 5 5 1 Nine Cysteines Domain of family 3 GPCR Ig_Tie2_1 PF10430.7 001168698.1_22426001_1 - 0.063 13.6 0.0 0.21 11.9 0.0 1.8 1 0 0 1 1 1 0 Tie-2 Ig-like domain 1 Myotub-related PF06602.12 001135516.1_43529001_3 - 5.1e-57 193.2 7.2 2.7e-51 174.4 5.4 2.1 1 1 0 2 2 2 2 Myotubularin-like phosphatase domain 3-PAP PF12578.6 001135516.1_43529001_3 - 5.2e-39 132.9 1.2 9.1e-39 132.1 1.2 1.3 1 0 0 1 1 1 1 Myotubularin-associated protein Thyroglobulin_1 PF00086.16 001134302.1_39522001_1 - 7.9e-20 70.2 1.1 7.9e-20 70.2 1.1 2.3 2 0 0 2 2 2 1 Thyroglobulin type-1 repeat IGFBP PF00219.16 001134302.1_39522001_1 - 7.6e-10 39.2 21.2 7.6e-10 39.2 21.2 2.9 3 0 0 3 3 3 1 Insulin-like growth factor binding protein Defensin_beta PF00711.17 213838.1_49821001_3 - 2e-14 53.2 9.4 4e-14 52.2 9.4 1.5 1 0 0 1 1 1 1 Beta defensin SEA PF01390.18 001014398.2_32926001_3 - 8.1e-05 22.7 0.0 0.027 14.6 0.0 3.2 3 0 0 3 3 3 1 SEA domain V-set PF07686.15 001009040.1_39724001_1 - 9.8e-28 96.4 9.6 1.3e-12 47.7 0.3 4.9 4 2 1 5 5 5 3 Immunoglobulin V-set domain Ig_3 PF13927.4 001009040.1_39724001_1 - 6.1e-21 74.7 9.4 5e-10 39.7 0.0 4.9 4 1 0 4 4 4 4 Immunoglobulin domain I-set PF07679.14 001009040.1_39724001_1 - 3.5e-17 62.1 0.1 2.8e-08 33.6 0.0 4.7 4 2 0 4 4 4 3 Immunoglobulin I-set domain ig PF00047.23 001009040.1_39724001_1 - 3.1e-15 56.0 5.1 7.1e-05 22.8 0.0 4.8 4 1 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.4 001009040.1_39724001_1 - 2.9e-14 53.0 9.8 6.3e-08 32.7 0.0 4.5 4 2 0 4 4 4 2 Immunoglobulin domain C2-set_2 PF08205.10 001009040.1_39724001_1 - 7.2e-05 22.7 8.0 0.0067 16.3 2.1 4.2 2 2 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Receptor_2B4 PF11465.6 001009040.1_39724001_1 - 0.014 15.4 0.0 2 8.5 0.0 2.5 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 Herpes_gI PF01688.15 001009040.1_39724001_1 - 0.11 12.3 0.0 18 5.0 0.0 2.9 2 1 1 3 3 3 0 Alphaherpesvirus glycoprotein I Motilin_ghrelin PF04644.10 001009040.1_39724001_3 - 0.11 12.2 3.8 3.1 7.6 1.0 2.3 2 0 0 2 2 2 0 Motilin/ghrelin TNF PF00229.16 001112648.1_40422001_1 - 2.4e-39 134.1 0.0 3.1e-39 133.7 0.0 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family TIMP PF00965.15 001009319.2_39522001_1 - 1.8e-61 207.0 2.4 1.8e-61 207.0 2.4 1.3 2 0 0 2 2 2 1 Tissue inhibitor of metalloproteinase NTR PF01759.19 001009319.2_39522001_1 - 0.0039 16.8 0.0 0.0063 16.2 0.0 1.3 1 0 0 1 1 1 1 UNC-6/NTR/C345C module START PF01852.17 001009319.2_39522001_2 - 0.012 14.8 0.0 0.019 14.2 0.0 1.2 1 0 0 1 1 1 0 START domain THF_DHG_CYH_C PF02882.17 001107211.1_45725001_2 - 5.5e-61 204.4 3.1 7.2e-61 204.0 3.1 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.21 001107211.1_45725001_2 - 4.4e-37 126.8 0.0 6.3e-37 126.3 0.0 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Pkinase PF00069.23 001082236.1_37926001_1 - 2.3e-68 230.3 0.0 3e-68 229.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001082236.1_37926001_1 - 2.2e-39 135.2 0.1 3e-39 134.8 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 001082236.1_37926001_1 - 0.0073 15.5 0.2 0.012 14.8 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 001082236.1_37926001_1 - 0.088 12.0 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.21 001082236.1_37926001_1 - 0.19 11.5 2.9 0.2 11.4 0.1 2.3 2 1 0 3 3 3 0 Phosphotransferase enzyme family IL12p40_C PF10420.7 001044725.1_29623001_1 - 5.9e-22 77.8 0.5 5.9e-22 77.8 0.5 2.1 2 0 0 2 2 2 1 Cytokine interleukin-12p40 C-terminus Ig_3 PF13927.4 001044725.1_29623001_1 - 1.1e-05 25.8 3.7 0.00037 20.9 0.0 2.9 3 0 0 3 3 3 1 Immunoglobulin domain Ig_5 PF16681.3 001044725.1_29623001_1 - 1.3e-05 25.4 0.2 9.4e-05 22.6 0.0 2.3 1 1 1 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_2 PF13895.4 001044725.1_29623001_1 - 1.3e-05 25.3 0.1 0.00027 21.1 0.0 2.5 1 1 1 2 2 2 1 Immunoglobulin domain Ig_4 PF16680.3 001044725.1_29623001_1 - 0.00013 22.1 0.1 0.0007 19.8 0.0 2.2 1 1 1 2 2 2 1 T-cell surface glycoprotein CD3 delta chain fn3 PF00041.19 001044725.1_29623001_1 - 0.00014 22.0 0.2 0.00085 19.5 0.1 2.3 2 0 0 2 2 2 1 Fibronectin type III domain I-set PF07679.14 001044725.1_29623001_1 - 0.058 13.3 1.6 0.81 9.7 0.1 3.4 4 1 0 4 4 4 0 Immunoglobulin I-set domain V-set PF07686.15 001044725.1_29623001_1 - 0.28 11.2 4.1 28 4.8 0.0 3.5 3 1 1 4 4 4 0 Immunoglobulin V-set domain CSTF2_hinge PF14327.4 001131639.2_43524001_3 - 1.1e-30 105.7 3.7 2.6e-30 104.5 3.7 1.7 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.20 001131639.2_43524001_3 - 1.1e-25 89.1 0.0 1.9e-25 88.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.4 001131639.2_43524001_3 - 3.5e-19 68.0 12.9 5.7e-19 67.3 10.0 2.3 2 0 0 2 2 2 1 Transcription termination and cleavage factor C-terminal RRM_7 PF16367.3 001131639.2_43524001_3 - 0.017 15.1 0.0 0.038 14.0 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif Gla PF00594.18 001131847.1_43529001_3 - 5.2e-18 64.8 14.3 9.3e-18 64.0 14.3 1.4 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain RCR PF12273.6 001131847.1_43529001_3 - 0.05 14.1 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red DUF2207 PF09972.7 001131847.1_43529001_3 - 0.079 11.6 0.0 0.16 10.6 0.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) IL1 PF00340.17 001101684.1_37924001_1 - 6.4e-37 125.8 0.0 1e-36 125.1 0.0 1.3 1 0 0 1 1 1 1 Interleukin-1 / 18 IL1_propep PF02394.14 001101684.1_37924001_1 - 5.5e-36 123.6 0.7 1e-35 122.8 0.7 1.4 1 0 0 1 1 1 1 Interleukin-1 propeptide Cystatin PF00031.19 009978.2_32922001_2 - 3.1e-22 78.5 0.3 4.1e-22 78.1 0.3 1.2 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.3 009978.2_32922001_2 - 8.4e-06 25.9 0.1 1.5e-05 25.1 0.1 1.4 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor Crystallin PF00525.16 001082406.2_37923001_2 - 6.8e-26 90.1 2.3 6.8e-26 90.1 2.3 1.9 2 0 0 2 2 2 1 Alpha crystallin A chain, N terminal HSP20 PF00011.19 001082406.2_37923001_2 - 3e-22 78.6 0.0 3.9e-22 78.2 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family COX4 PF02936.12 001170882.1_37922001_2 - 2.7e-58 195.8 0.6 3.2e-58 195.5 0.6 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV LRR_8 PF13855.4 001130469.1_39725001_1 - 5.3e-35 118.9 47.5 1e-13 50.7 7.4 7.9 5 2 2 7 7 7 7 Leucine rich repeat TIR PF01582.18 001130469.1_39725001_1 - 9.1e-22 77.6 1.9 1e-21 77.4 0.6 1.8 2 0 0 2 2 2 1 TIR domain LRR_4 PF12799.5 001130469.1_39725001_1 - 1.6e-19 69.4 49.5 0.00086 19.5 4.6 9.3 7 1 2 10 10 10 6 Leucine Rich repeats (2 copies) TIR_2 PF13676.4 001130469.1_39725001_1 - 1.1e-09 38.4 0.1 2.9e-09 37.1 0.0 1.8 2 0 0 2 2 2 1 TIR domain LRR_9 PF14580.4 001130469.1_39725001_1 - 7e-09 35.3 15.6 7.4e-05 22.2 0.4 4.5 2 2 1 4 4 4 2 Leucine-rich repeat LRR_5 PF13306.4 001130469.1_39725001_1 - 4.9e-06 26.4 1.0 4.9e-06 26.4 1.0 4.2 3 1 1 4 4 4 2 Leucine rich repeats (6 copies) LRRCT PF01463.22 001130469.1_39725001_1 - 0.00019 21.6 0.2 0.00073 19.8 0.2 2.1 2 0 0 2 2 2 1 Leucine rich repeat C-terminal domain LRR_1 PF00560.31 001130469.1_39725001_1 - 0.00044 20.2 38.6 0.11 12.9 0.6 10.7 11 1 0 11 11 11 3 Leucine Rich Repeat DUF1863 PF08937.9 001130469.1_39725001_1 - 0.18 12.0 0.4 0.76 10.0 0.4 2.0 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) GHBP PF12772.5 001009323.2_39525001_2 - 5.1e-133 443.1 5.1 6.5e-133 442.7 5.1 1.1 1 0 0 1 1 1 1 Growth hormone receptor binding EpoR_lig-bind PF09067.8 001009323.2_39525001_2 - 5.2e-12 45.8 1.9 1.5e-11 44.3 1.9 1.8 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding fn3 PF00041.19 001009323.2_39525001_2 - 1.1e-05 25.5 0.1 2.3e-05 24.5 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III domain IL6Ra-bind PF09240.8 001009323.2_39525001_2 - 0.032 14.5 1.1 0.072 13.4 1.1 1.5 1 0 0 1 1 1 0 Interleukin-6 receptor alpha chain, binding PET PF06297.12 001195318.1_39526001_1 - 8e-41 138.1 3.0 1.4e-40 137.3 3.0 1.4 1 0 0 1 1 1 1 PET Domain LIM PF00412.20 001195318.1_39526001_1 - 3.4e-27 94.3 59.1 7.7e-14 51.5 8.4 4.5 4 1 1 5 5 5 3 LIM domain Ig_Tie2_1 PF10430.7 001195318.1_39526001_1 - 0.056 13.7 0.0 0.2 11.9 0.0 1.9 1 0 0 1 1 1 0 Tie-2 Ig-like domain 1 Ig_2 PF13895.4 001009056.1_39724001_2 - 8.9e-37 125.2 0.1 3e-14 53.0 0.0 4.2 4 0 0 4 4 4 4 Immunoglobulin domain Ig_3 PF13927.4 001009056.1_39724001_2 - 8.5e-27 93.5 0.2 5.6e-06 26.7 0.0 4.3 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.23 001009056.1_39724001_2 - 4.2e-24 84.4 0.0 2.8e-07 30.5 0.0 4.2 4 0 0 4 4 4 4 Immunoglobulin domain V-set PF07686.15 001009056.1_39724001_2 - 2e-06 27.8 2.0 2.1 8.4 0.4 5.4 4 2 0 5 5 5 2 Immunoglobulin V-set domain I-set PF07679.14 001009056.1_39724001_2 - 0.0081 16.1 0.0 8.7 6.4 0.0 3.5 3 0 0 3 3 3 1 Immunoglobulin I-set domain Thioredoxin PF00085.18 001007643.1_45724001_2 - 3e-11 43.0 0.0 5.4e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Sushi PF00084.18 001009415.1_39526001_3 - 1.5e-06 28.6 4.5 0.018 15.5 0.6 2.6 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) Ribosomal_L16 PF00252.16 001112820.1_39522001_2 - 2.1e-44 150.6 0.3 2.6e-44 150.3 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Pkinase PF00069.23 001099954.1_37927001_3 - 9e-75 251.3 0.0 1.3e-74 250.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain CaMKII_AD PF08332.8 001099954.1_37927001_3 - 1.7e-59 199.5 0.0 2.5e-59 198.9 0.0 1.3 1 0 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II association domain Pkinase_Tyr PF07714.15 001099954.1_37927001_3 - 3.8e-31 108.2 0.0 6.5e-31 107.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase SnoaL_3 PF13474.4 001099954.1_37927001_3 - 2.2e-08 34.3 0.0 4.5e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.4 001099954.1_37927001_3 - 4e-08 33.5 0.0 6.8e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) Kdo PF06293.12 001099954.1_37927001_3 - 0.012 14.8 0.0 0.025 13.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001099954.1_37927001_3 - 0.016 15.0 0.0 6.9 6.4 0.0 2.3 1 1 0 2 2 2 0 Phosphotransferase enzyme family SnoaL_4 PF13577.4 001099954.1_37927001_3 - 0.054 13.5 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 SnoaL-like domain SnoaL_2 PF12680.5 001099954.1_37927001_3 - 0.077 13.5 0.0 0.15 12.6 0.0 1.5 1 0 0 1 1 1 0 SnoaL-like domain Lipase PF00151.17 001112612.1_40428001_1 - 3.6e-130 434.1 0.0 5e-130 433.6 0.0 1.1 1 0 0 1 1 1 1 Lipase PLAT PF01477.21 001112612.1_40428001_1 - 4.2e-25 88.5 0.6 6.6e-25 87.8 0.6 1.3 1 0 0 1 1 1 1 PLAT/LH2 domain Abhydrolase_6 PF12697.5 001112612.1_40428001_1 - 0.00014 22.4 0.2 0.00023 21.8 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.18 001112612.1_40428001_1 - 0.0012 18.4 0.0 0.0018 17.8 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold RNA_pol_Rpc4 PF05132.12 001131836.1_43526001_1 - 0.022 15.1 18.0 0.032 14.6 18.0 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 SpoIIP PF07454.9 001131836.1_43526001_1 - 9.3 5.5 24.0 12 5.1 24.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) RNA_pol_Rpc4 PF05132.12 001131836.1_43526001_2 - 0.0015 18.9 15.1 0.0022 18.3 15.1 1.2 1 0 0 1 1 1 1 RNA polymerase III RPC4 DDHD PF02862.15 001131836.1_43526001_2 - 0.03 14.3 9.1 0.039 14.0 9.1 1.1 1 0 0 1 1 1 0 DDHD domain Cpn60_TCP1 PF00118.22 001131836.1_43526001_3 - 1.6e-168 561.2 7.0 2.2e-168 560.8 7.0 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF913 PF06025.10 001131836.1_43526001_3 - 1.6 7.5 8.2 2.8 6.7 8.2 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SpoIIP PF07454.9 001131836.1_43526001_3 - 1.7 7.9 22.3 2.8 7.2 22.3 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) RNA_pol_Rpc4 PF05132.12 001131836.1_43526001_3 - 9.3 6.6 27.1 17 5.7 27.1 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 DAP10 PF07213.9 001032867.1_29622001_3 - 0.0035 17.1 3.2 0.0055 16.5 3.2 1.3 1 0 0 1 1 1 1 DAP10 membrane protein IncA PF04156.12 001032867.1_29622001_3 - 0.098 12.3 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 IncA protein Ammonium_transp PF00909.19 001129743.1_39723001_1 - 9.4e-62 208.8 23.6 1.2e-61 208.5 23.6 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DNA_pol_B_thumb PF14791.4 001032979.1_32324001_3 - 1.1e-19 70.1 0.3 4.2e-19 68.3 0.1 2.1 2 0 0 2 2 2 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.7 001032979.1_32324001_3 - 4.5e-19 67.9 0.1 1.1e-18 66.7 0.1 1.7 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.4 001032979.1_32324001_3 - 7.3e-11 42.2 0.0 2e-10 40.7 0.0 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix domain DNA_pol_B_palm PF14792.4 001032979.1_32324001_3 - 1.2e-09 38.2 0.0 3e-09 37.0 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase beta palm BRCT PF00533.24 001032979.1_32324001_3 - 3e-07 30.6 0.3 7.4e-07 29.4 0.3 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain NTP_transf_2 PF01909.21 001032979.1_32324001_3 - 5.7e-05 23.2 0.0 0.00017 21.7 0.0 1.8 1 0 0 1 1 1 1 Nucleotidyltransferase domain BRCT_2 PF16589.3 001032979.1_32324001_3 - 0.0032 17.7 0.0 0.0065 16.7 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Cdd1 PF11731.6 001032979.1_32324001_3 - 0.022 14.8 0.0 0.06 13.4 0.0 1.7 1 0 0 1 1 1 0 Pathogenicity locus HHH_5 PF14520.4 001032979.1_32324001_3 - 0.058 13.9 0.0 0.15 12.6 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix domain PTCB-BRCT PF12738.5 001032979.1_32324001_3 - 0.1 12.4 0.0 0.3 10.9 0.0 1.8 1 0 0 1 1 1 0 twin BRCT domain Defensin_beta_2 PF13841.4 001129771.1_39721001_1 - 2.2e-07 31.1 10.7 3.2e-07 30.6 10.7 1.3 1 0 0 1 1 1 1 Beta defensin Prion_bPrPp PF11587.6 001129771.1_39721001_1 - 9.7 6.0 9.8 0.35 10.6 3.1 2.0 2 0 0 2 2 2 0 Major prion protein bPrPp - N terminal DUF3265 PF11665.6 001168713.1_40426001_1 - 0.012 15.6 1.1 0.03 14.4 1.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3265) PET PF06297.12 001168713.1_40426001_3 - 1.4e-40 137.3 2.7 2.6e-40 136.5 2.7 1.5 1 0 0 1 1 1 1 PET Domain LIM PF00412.20 001168713.1_40426001_3 - 6.5e-26 90.2 61.9 9e-14 51.3 8.1 4.6 5 1 1 6 6 6 3 LIM domain Ig_Tie2_1 PF10430.7 001168713.1_40426001_3 - 0.067 13.5 0.0 0.23 11.8 0.0 1.9 1 0 0 1 1 1 0 Tie-2 Ig-like domain 1 Pkinase PF00069.23 001133477.1_43527001_1 - 3.6e-143 475.5 0.3 1.4e-72 244.1 0.1 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 001133477.1_43527001_1 - 5.6e-66 222.3 0.0 8.7e-32 110.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.4 001133477.1_43527001_1 - 6e-13 48.6 0.1 2.5e-05 23.6 0.0 3.1 3 0 0 3 3 3 2 Kinase-like Kdo PF06293.12 001133477.1_43527001_1 - 8e-12 44.8 0.3 2.3e-08 33.5 0.0 2.2 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_C PF00433.22 001133477.1_43527001_1 - 2.8e-09 37.4 0.5 8.7e-09 35.8 0.5 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain APH PF01636.21 001133477.1_43527001_1 - 7.4e-09 35.7 0.4 0.0002 21.2 0.0 3.6 2 2 2 4 4 4 2 Phosphotransferase enzyme family FTA2 PF13095.4 001133477.1_43527001_1 - 5.5e-06 26.0 0.8 1 8.8 0.0 3.3 3 0 0 3 3 3 3 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.20 001133477.1_43527001_1 - 1.1e-05 25.0 1.3 0.00026 20.5 0.1 2.5 2 0 0 2 2 2 1 RIO1 family Choline_kinase PF01633.18 001133477.1_43527001_1 - 0.0032 16.9 1.6 0.029 13.8 0.0 2.7 3 0 0 3 3 3 1 Choline/ethanolamine kinase YrbL-PhoP_reg PF10707.7 001133477.1_43527001_1 - 0.094 12.1 0.3 7.3 5.9 0.0 2.7 2 1 0 2 2 2 0 PhoP regulatory network protein YrbL SR-25 PF10500.7 001133477.1_43527001_1 - 0.14 11.6 7.2 0.29 10.6 7.2 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CaMBD PF02888.14 001133477.1_43527001_1 - 0.35 11.0 1.9 6.7 6.9 0.3 2.4 2 0 0 2 2 2 0 Calmodulin binding domain LRR_8 PF13855.4 001082116.1_37925001_1 - 1.1e-18 66.6 5.6 5.8e-10 38.7 0.1 3.9 4 0 0 4 4 4 3 Leucine rich repeat LRR_4 PF12799.5 001082116.1_37925001_1 - 8e-10 38.6 9.9 9.9e-05 22.5 1.2 4.3 1 1 4 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001082116.1_37925001_1 - 0.0032 17.6 9.8 4.3 8.1 0.0 5.7 5 1 0 5 5 5 1 Leucine Rich Repeat LRR_6 PF13516.4 001082116.1_37925001_1 - 0.041 13.8 0.7 16 5.7 0.0 3.9 4 0 0 4 4 4 0 Leucine Rich repeat LRR_9 PF14580.4 001082116.1_37925001_1 - 0.073 12.4 1.4 0.36 10.2 0.1 2.1 1 1 1 2 2 2 0 Leucine-rich repeat UPAR_LY6 PF00021.19 001009031.1_39723001_3 - 1.2e-25 89.8 48.8 3.6e-12 46.7 7.2 3.2 3 0 0 3 3 3 3 u-PAR/Ly-6 domain Toxin_1 PF00087.19 001009031.1_39723001_3 - 0.038 14.1 42.8 0.11 12.6 8.5 3.5 3 0 0 3 3 3 0 Snake toxin Hormone_5 PF00184.15 001126341.1_39522001_1 - 3.4e-32 111.0 26.2 5.3e-32 110.4 26.2 1.3 1 0 0 1 1 1 1 Neurohypophysial hormones, C-terminal Domain Hormone_4 PF00220.15 001126341.1_39522001_1 - 0.00014 21.3 3.3 0.0005 19.6 3.3 2.0 1 0 0 1 1 1 1 Neurohypophysial hormones, N-terminal Domain TNF PF00229.16 001047149.1_29622001_1 - 1.6e-40 137.9 0.0 2.1e-40 137.5 0.0 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family Biopterin_H PF00351.19 001082272.1_37925001_3 - 6.9e-172 570.8 0.0 9e-172 570.5 0.0 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.23 001082272.1_37925001_3 - 1.1e-05 24.9 0.0 2.4e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.4 001082272.1_37925001_3 - 0.058 13.8 1.1 0.075 13.5 0.1 1.6 2 0 0 2 2 2 0 ACT domain IL1 PF00340.17 001082201.1_37923001_3 - 2.9e-42 143.0 0.3 5.3e-42 142.2 0.3 1.4 1 0 0 1 1 1 1 Interleukin-1 / 18 IL1_propep PF02394.14 001082201.1_37923001_3 - 3.1e-39 134.1 0.2 6.9e-39 133.0 0.0 1.7 2 0 0 2 2 2 1 Interleukin-1 propeptide Gp_dh_C PF02800.18 001009307.1_22423001_1 - 5.7e-70 233.8 0.0 8.3e-70 233.3 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.22 001009307.1_22423001_1 - 1.3e-39 134.5 0.1 2.8e-39 133.4 0.1 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.18 001009307.1_22423001_1 - 0.046 13.7 0.1 0.15 12.0 0.0 1.9 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus zf-RING_UBOX PF13445.4 001082015.1_37925001_2 - 1.5e-10 40.8 2.9 3.3e-10 39.7 2.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 001082015.1_37925001_2 - 2.4e-10 40.2 9.4 2.4e-10 40.2 9.4 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING PRY PF13765.4 001082015.1_37925001_2 - 3e-10 39.4 0.1 6.3e-10 38.4 0.1 1.6 1 0 0 1 1 1 1 SPRY-associated domain zf-B_box PF00643.22 001082015.1_37925001_2 - 5.1e-09 36.0 0.4 5.1e-09 36.0 0.4 2.9 3 0 0 3 3 3 1 B-box zinc finger SPRY PF00622.26 001082015.1_37925001_2 - 4.7e-08 33.0 0.0 8.5e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 SPRY domain zf-C3HC4 PF00097.23 001082015.1_37925001_2 - 8.9e-08 31.8 7.0 1.8e-07 30.7 7.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001082015.1_37925001_2 - 4.5e-06 26.3 8.6 1.3e-05 24.8 8.6 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001082015.1_37925001_2 - 1.9e-05 24.7 8.4 1.9e-05 24.7 8.4 1.9 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.4 001082015.1_37925001_2 - 5.9e-05 22.7 7.0 5.9e-05 22.7 7.0 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001082015.1_37925001_2 - 0.00011 22.0 7.8 0.00011 22.0 7.8 2.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-Nse PF11789.6 001082015.1_37925001_2 - 0.0023 17.6 3.9 0.0044 16.7 3.9 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.4 001082015.1_37925001_2 - 0.0082 15.9 2.0 0.017 14.9 2.0 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_4 PF14570.4 001082015.1_37925001_2 - 0.17 11.5 6.9 0.66 9.6 7.0 2.0 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain K-box PF01486.15 001082015.1_37925001_2 - 0.18 11.9 4.8 0.3 11.2 4.8 1.3 1 0 0 1 1 1 0 K-box region Prok-RING_4 PF14447.4 001082015.1_37925001_2 - 0.19 11.5 10.5 2.3 8.0 10.6 2.6 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 HrpB7 PF09486.8 001082015.1_37925001_2 - 0.22 11.8 3.4 0.12 12.6 0.4 1.8 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) zf-RING_10 PF16685.3 001082015.1_37925001_2 - 2.8 8.0 10.3 0.14 12.2 4.5 1.9 2 0 0 2 2 2 0 zinc RING finger of MSL2 Ank_2 PF12796.5 001082657.1_37926001_3 - 1e-34 118.8 13.5 1.2e-12 48.1 1.6 3.5 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ion_trans PF00520.29 001082657.1_37926001_3 - 8.6e-24 84.0 15.9 1.9e-23 82.9 15.9 1.5 1 0 0 1 1 1 1 Ion transport protein Ank PF00023.28 001082657.1_37926001_3 - 3e-16 58.9 4.2 0.00019 21.6 0.2 5.7 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.4 001082657.1_37926001_3 - 5.4e-16 58.6 3.2 3e-05 24.4 0.5 4.3 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.4 001082657.1_37926001_3 - 5.7e-15 53.8 12.1 0.00024 21.2 0.1 6.8 7 0 0 7 7 7 3 Ankyrin repeat Ank_5 PF13857.4 001082657.1_37926001_3 - 1e-13 51.0 5.8 0.00016 21.8 0.0 4.5 3 1 1 4 4 4 4 Ankyrin repeats (many copies) PRY PF13765.4 001123207.1_49823001_1 - 5.5e-20 70.6 1.6 9.1e-20 69.9 0.2 2.2 3 0 0 3 3 3 1 SPRY-associated domain SPRY PF00622.26 001123207.1_49823001_1 - 1.4e-11 44.4 0.0 2.7e-11 43.5 0.0 1.5 1 0 0 1 1 1 1 SPRY domain zf-C3HC4 PF00097.23 001123207.1_49823001_1 - 5.7e-07 29.2 12.4 5.7e-07 29.2 12.4 2.7 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001123207.1_49823001_1 - 9.4e-07 28.8 4.4 9.4e-07 28.8 4.4 3.6 2 1 1 3 3 2 1 B-box zinc finger zf-C3HC4_4 PF15227.4 001123207.1_49823001_1 - 2.4e-06 27.5 15.1 2.4e-06 27.5 15.1 3.0 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 001123207.1_49823001_1 - 4.1e-06 26.4 10.1 4.1e-06 26.4 10.1 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001123207.1_49823001_1 - 0.00011 22.1 10.3 0.00011 22.1 10.3 3.6 4 0 0 4 4 4 1 RING-type zinc-finger zf-RING_2 PF13639.4 001123207.1_49823001_1 - 0.00011 22.2 13.0 0.00011 22.2 13.0 2.8 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.4 001123207.1_49823001_1 - 0.00013 21.6 13.8 0.00013 21.6 13.8 2.7 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.5 001123207.1_49823001_1 - 0.014 15.6 5.5 0.014 15.6 5.5 2.9 2 1 1 3 3 3 0 RING-H2 zinc finger domain zf-RING_5 PF14634.4 001123207.1_49823001_1 - 5.2 7.0 23.3 0.027 14.3 10.7 3.3 3 1 0 3 3 3 0 zinc-RING finger domain Baculo_IE-1 PF05290.9 001123207.1_49823001_1 - 5.8 6.7 12.8 0.13 12.1 3.8 2.4 3 0 0 3 3 3 0 Baculovirus immediate-early protein (IE-0) zf-Nse PF11789.6 001123207.1_49823001_1 - 6.7 6.5 8.9 15 5.3 8.5 1.8 1 1 1 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit Agouti PF05039.10 001135627.1_39721001_1 - 1.1e-29 102.9 14.9 1.4e-29 102.5 14.9 1.2 1 0 0 1 1 1 1 Agouti protein Toxin_9 PF02819.13 001135627.1_39721001_1 - 0.21 11.7 16.5 0.31 11.2 16.5 1.3 1 0 0 1 1 1 0 Spider toxin Ig_5 PF16681.3 001283615.1_29522001_1 - 8.8e-35 118.9 0.1 1.3e-34 118.3 0.1 1.3 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 001283615.1_29522001_1 - 9.5e-19 67.4 0.1 1.5e-18 66.8 0.1 1.3 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 delta chain ITAM PF02189.13 001283615.1_29522001_1 - 4.2e-05 23.6 0.7 8.3e-05 22.7 0.7 1.5 1 0 0 1 1 1 1 Immunoreceptor tyrosine-based activation motif Ig_2 PF13895.4 001283615.1_29522001_1 - 0.00071 19.7 0.1 0.0013 18.9 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain P5-ATPase PF12409.6 001283615.1_29522001_1 - 0.047 13.7 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 P5-type ATPase cation transporter Virul_fac_BrkB PF03631.13 001283615.1_29522001_1 - 0.17 11.4 0.0 0.25 10.8 0.0 1.2 1 0 0 1 1 1 0 Virulence factor BrkB Pkinase_Tyr PF07714.15 001242736.1_37629001_3 - 1.2e-92 309.7 0.0 1.8e-92 309.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Sema PF01403.17 001242736.1_37629001_3 - 6.4e-58 196.4 1.1 9.4e-58 195.8 1.1 1.2 1 0 0 1 1 1 1 Sema domain Pkinase PF00069.23 001242736.1_37629001_3 - 1.1e-40 139.5 0.0 2.5e-40 138.4 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain TIG PF01833.22 001242736.1_37629001_3 - 6.6e-33 112.5 14.7 9.8e-12 44.7 0.2 5.0 5 0 0 5 5 5 3 IPT/TIG domain PSI PF01437.23 001242736.1_37629001_3 - 0.00019 21.8 15.0 0.00019 21.8 15.0 3.6 4 0 0 4 4 4 1 Plexin repeat Kinase-like PF14531.4 001242736.1_37629001_3 - 0.00042 19.6 0.0 0.0007 18.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Sel1 PF08238.10 001281362.1_31325001_1 - 4.5e-57 189.1 39.2 4.2e-08 33.5 0.9 12.8 13 0 0 13 13 13 9 Sel1 repeat fn2 PF00040.17 001281362.1_31325001_1 - 1.3e-17 63.7 7.3 2.4e-17 62.8 7.3 1.5 1 0 0 1 1 1 1 Fibronectin type II domain TPR_6 PF13174.4 001281362.1_31325001_1 - 1.1 9.9 19.8 19 6.0 0.1 7.5 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_16 PF13432.4 001281362.1_31325001_1 - 1.9 9.1 9.9 12 6.6 0.3 5.1 5 1 0 5 5 5 0 Tetratricopeptide repeat Abhydro_lipase PF04083.14 001281693.1_31324001_3 - 5.1e-21 73.9 0.1 4.7e-20 70.8 0.0 2.3 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.18 001281693.1_31324001_3 - 1.3e-19 70.7 0.1 1.8e-19 70.3 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 001281693.1_31324001_3 - 2.4e-08 33.4 0.0 9.9e-07 28.1 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 LIDHydrolase PF10230.7 001281693.1_31324001_3 - 0.00022 20.8 0.0 0.0004 19.9 0.0 1.4 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_6 PF12697.5 001281693.1_31324001_3 - 0.045 14.2 0.0 0.059 13.9 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF2974 PF11187.6 001281693.1_31324001_3 - 0.1 12.0 0.0 0.26 10.7 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) zf-H2C2_2 PF13465.4 001283856.1_29526001_1 - 1.6e-83 271.5 114.7 7.1e-08 32.4 0.4 18.2 18 0 0 18 18 18 14 Zinc-finger double domain zf-C2H2 PF00096.24 001283856.1_29526001_1 - 2.5e-69 225.9 108.1 4.6e-05 23.5 0.4 16.5 16 0 0 16 16 16 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001283856.1_29526001_1 - 4.4e-51 166.9 109.7 8.3e-05 23.0 0.8 16.8 17 0 0 17 17 16 16 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001283856.1_29526001_1 - 6.6e-23 80.3 42.8 0.004 17.3 0.0 14.9 16 0 0 16 16 15 6 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001283856.1_29526001_1 - 1.5e-16 59.7 93.3 0.0027 17.5 0.5 16.2 16 1 0 16 16 16 9 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001283856.1_29526001_1 - 4.3e-05 23.4 74.8 0.018 15.0 1.9 12.2 6 3 9 15 15 15 6 Zinc ribbon domain zf-LYAR PF08790.9 001283856.1_29526001_1 - 0.0026 17.5 39.0 1.7 8.5 0.1 11.3 13 0 0 13 13 13 2 LYAR-type C2HC zinc finger BDHCT_assoc PF16204.3 001283856.1_29526001_1 - 0.0092 15.6 3.2 7.2 6.1 0.1 3.2 3 0 0 3 3 3 1 BDHCT-box associated domain on Bloom syndrome protein zf-C2H2_11 PF16622.3 001283856.1_29526001_1 - 0.0093 15.6 74.3 0.02 14.5 0.1 13.5 15 0 0 15 15 15 5 zinc-finger C2H2-type zf-C2HC_2 PF13913.4 001283856.1_29526001_1 - 0.016 15.0 1.1 0.016 15.0 1.1 12.5 13 0 0 13 13 13 0 zinc-finger of a C2HC-type zinc_ribbon_15 PF17032.3 001283856.1_29526001_1 - 0.024 15.2 42.3 0.54 10.9 0.2 8.1 6 3 1 8 8 8 0 zinc-ribbon family zf-AN1 PF01428.14 001283856.1_29526001_1 - 0.06 13.4 67.9 4 7.5 0.3 15.2 15 1 0 16 16 16 0 AN1-like Zinc finger DUF3268 PF11672.6 001283856.1_29526001_1 - 0.065 13.4 23.0 2.4 8.4 0.1 6.9 7 0 0 7 7 7 0 zinc-finger-containing domain C1_4 PF07975.10 001283856.1_29526001_1 - 0.72 10.0 52.7 0.44 10.7 0.1 10.1 4 1 11 15 15 15 0 TFIIH C1-like domain zf-met PF12874.5 001283856.1_29526001_1 - 1.4 9.2 80.4 0.22 11.8 0.4 13.9 15 0 0 15 15 14 0 Zinc-finger of C2H2 type HypA PF01155.17 001283856.1_29526001_1 - 2 8.3 47.7 8.9 6.2 2.4 8.6 2 2 6 8 8 8 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2HE PF16278.3 001283856.1_29526001_1 - 6.7 7.1 71.0 3.6 8.0 0.4 14.7 4 3 9 13 13 12 0 C2HE / C2H2 / C2HC zinc-binding finger GFO_IDH_MocA PF01408.20 001195678.1_37923001_1 - 9.7e-22 77.9 0.2 2.4e-21 76.7 0.1 1.6 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.14 001195678.1_37923001_1 - 0.0036 17.8 0.2 0.0081 16.7 0.1 1.6 2 0 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain GFO_IDH_MocA_C PF02894.15 001195678.1_37923001_1 - 0.024 14.5 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain F420_oxidored PF03807.15 001195678.1_37923001_1 - 0.04 14.4 0.0 0.12 12.9 0.0 1.8 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent PHP_C PF13263.4 001195678.1_37923001_1 - 0.071 12.7 0.1 0.16 11.6 0.1 1.6 1 0 0 1 1 1 0 PHP-associated DUF4389 PF14333.4 001195678.1_37923001_1 - 0.11 12.2 0.2 0.87 9.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4389) Serpin PF00079.18 001279625.1_24224001_1 - 3.3e-56 191.0 0.0 5e-56 190.5 0.0 1.3 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Nuc_rec_co-act PF08815.8 001279625.1_24224001_1 - 0.031 14.0 0.4 0.13 12.0 0.2 2.1 2 0 0 2 2 2 0 Nuclear receptor coactivator GST_C_3 PF14497.4 001171097.1_37922001_2 - 4.5e-18 65.2 0.0 7.7e-18 64.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.18 001171097.1_37922001_2 - 1.1e-17 64.0 0.0 4.7e-17 62.0 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 001171097.1_37922001_2 - 6.6e-16 58.2 0.3 1.5e-15 57.1 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Collagen PF01391.16 001281576.1_31329001_1 - 5.8e-46 153.9 369.9 1.5e-09 37.3 31.5 17.6 12 3 3 15 15 15 11 Collagen triple helix repeat (20 copies) DUF2868 PF11067.6 001281576.1_31329001_1 - 0.013 14.9 1.8 0.021 14.2 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) 7tm_1 PF00001.19 001172957.2_09923001_1 - 1.1e-40 139.5 11.6 1.1e-40 139.5 11.6 1.6 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) Colicin_V PF02674.14 001172957.2_09923001_1 - 0.039 13.8 1.8 1.5 8.7 0.1 3.1 3 0 0 3 3 3 0 Colicin V production protein ITI_HC_C PF06668.10 001281350.1_31326001_3 - 1.6e-70 236.5 0.1 2.8e-70 235.7 0.1 1.4 1 0 0 1 1 1 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus VIT PF08487.8 001281350.1_31326001_3 - 9.3e-33 112.7 2.9 2e-32 111.6 2.9 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA PF00092.26 001281350.1_31326001_3 - 1.2e-23 84.1 0.1 2.4e-23 83.2 0.1 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.4 001281350.1_31326001_3 - 3.3e-11 43.2 0.0 5.4e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.4 001281350.1_31326001_3 - 2.9e-10 40.6 0.8 6.1e-10 39.6 0.3 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_CoxE PF05762.12 001281350.1_31326001_3 - 3.1e-05 23.3 0.0 5.1e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein vWA-TerF-like PF10138.7 001281350.1_31326001_3 - 0.00037 20.5 0.0 0.00063 19.8 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus Glyco_hydro_61 PF03443.12 001281350.1_31326001_3 - 0.00074 19.4 0.0 0.0016 18.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 CobT_C PF11775.6 001281350.1_31326001_3 - 0.083 12.4 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT VWA domain DUF788 PF05620.9 001283197.1_29524001_2 - 0.031 14.1 2.5 0.043 13.6 2.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF788) Cpn60_TCP1 PF00118.22 001283197.1_29524001_3 - 3.8e-147 490.7 11.7 4.5e-147 490.5 11.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF2529 PF10740.7 001283197.1_29524001_3 - 0.0055 16.2 0.3 0.018 14.5 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF2529) V-set PF07686.15 001171045.1_37928001_1 - 4.8e-53 177.8 8.1 1.8e-14 53.7 0.2 6.1 5 1 0 5 5 5 5 Immunoglobulin V-set domain ig PF00047.23 001171045.1_37928001_1 - 4.9e-22 77.8 8.1 1.3e-05 25.1 0.0 6.8 6 2 0 6 6 6 5 Immunoglobulin domain Ig_3 PF13927.4 001171045.1_37928001_1 - 2.2e-20 72.9 7.8 0.00017 22.0 0.4 5.6 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.14 001171045.1_37928001_1 - 3.6e-11 42.8 2.5 0.39 10.7 0.0 5.9 5 1 0 5 5 5 4 Immunoglobulin I-set domain Ig_2 PF13895.4 001171045.1_37928001_1 - 5.3e-10 39.4 7.7 0.0034 17.6 0.5 6.3 4 3 1 5 5 5 2 Immunoglobulin domain Izumo-Ig PF16706.3 001171045.1_37928001_1 - 4e-05 23.5 0.1 13 5.8 0.0 5.2 5 0 0 5 5 5 1 Izumo-like Immunoglobulin domain DUF3129 PF11327.6 001171045.1_37928001_1 - 0.1 12.9 0.0 9.5 6.5 0.0 3.6 3 2 0 4 4 4 0 Protein of unknown function (DUF3129) Receptor_2B4 PF11465.6 001171045.1_37928001_1 - 0.17 11.9 0.0 12 6.0 0.0 2.9 3 0 0 3 3 3 0 Natural killer cell receptor 2B4 Prothymosin PF03247.12 031975.2_45723001_3 - 9.3e-14 51.7 48.3 1.2e-13 51.3 48.3 1.1 1 0 0 1 1 1 1 Prothymosin/parathymosin family CDC27 PF09507.8 031975.2_45723001_3 - 0.00064 19.1 13.1 0.00081 18.8 13.1 1.1 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 Presenilin PF01080.15 031975.2_45723001_3 - 0.0021 16.8 0.2 0.0022 16.7 0.2 1.1 1 0 0 1 1 1 1 Presenilin Drc1-Sld2 PF11719.6 031975.2_45723001_3 - 0.096 12.1 13.9 0.14 11.5 13.9 1.2 1 0 0 1 1 1 0 DNA replication and checkpoint protein Paf1 PF03985.11 031975.2_45723001_3 - 1.2 7.9 21.2 1.6 7.5 21.2 1.2 1 0 0 1 1 1 0 Paf1 VIR_N PF15912.3 031975.2_45723001_3 - 2 7.9 14.3 3.6 7.1 14.3 1.4 1 0 0 1 1 1 0 Virilizer, N-terminal CDC45 PF02724.12 031975.2_45723001_3 - 5.5 5.0 21.2 7 4.7 21.2 1.0 1 0 0 1 1 1 0 CDC45-like protein FAM60A PF15396.4 031975.2_45723001_3 - 5.7 6.8 9.9 8.4 6.2 9.9 1.1 1 0 0 1 1 1 0 Protein Family FAM60A RRM_1 PF00076.20 001283479.1_29524001_1 - 1.2e-21 76.2 0.1 1.9e-21 75.5 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM1CTR PF08081.9 001283479.1_29524001_1 - 4.8e-17 61.6 17.9 4.8e-17 61.6 17.9 7.3 6 3 1 7 7 7 1 RBM1CTR (NUC064) family RRM_7 PF16367.3 001283479.1_29524001_1 - 0.0027 17.7 0.0 0.0059 16.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif GST_N PF02798.18 001281630.1_31322001_2 - 1.7e-22 79.4 0.0 3.4e-22 78.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 001281630.1_31322001_2 - 3.5e-19 68.7 0.1 1.1e-18 67.1 0.1 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 001281630.1_31322001_2 - 9.4e-17 60.9 0.1 2e-16 59.8 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.2 001281630.1_31322001_2 - 0.00021 20.9 0.3 0.00055 19.6 0.1 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 001281630.1_31322001_2 - 0.001 19.3 0.0 0.0022 18.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.4 001281630.1_31322001_2 - 0.011 15.5 0.0 0.029 14.2 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Lactamase_B_4 PF13691.4 001279745.1_24226001_1 - 2.6e-16 58.9 0.0 6.6e-16 57.6 0.0 1.8 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B_2 PF12706.5 001279745.1_24226001_1 - 4.6e-14 52.3 0.1 3.8e-11 42.7 1.0 3.2 3 1 0 3 3 3 2 Beta-lactamase superfamily domain Lactamase_B PF00753.25 001279745.1_24226001_1 - 0.00097 19.1 0.5 0.0038 17.1 0.2 2.1 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily 7tm_1 PF00001.19 001270566.1_45725001_2 - 6.6e-54 182.8 0.0 9.2e-54 182.3 0.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001270566.1_45725001_2 - 3.7e-05 23.1 5.1 0.0047 16.2 1.4 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001270566.1_45725001_2 - 0.00097 18.4 5.3 0.00097 18.4 5.3 2.1 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001270566.1_45725001_2 - 0.001 18.7 1.1 0.0016 18.1 1.1 1.2 1 0 0 1 1 1 1 Olfactory receptor DUF621 PF04789.13 001270566.1_45725001_2 - 0.23 10.5 6.9 0.37 9.8 6.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF621) Chibby PF14645.4 001283872.1_29524001_3 - 1.5e-13 51.0 22.1 2.4e-12 47.1 0.4 3.7 3 1 1 4 4 4 2 Chibby family ZapB PF06005.10 001283872.1_29524001_3 - 0.0056 17.0 34.1 0.017 15.4 6.6 3.6 3 1 0 3 3 3 2 Cell division protein ZapB JIP_LZII PF16471.3 001283872.1_29524001_3 - 0.22 11.6 18.7 7.2 6.7 2.5 4.3 4 0 0 4 4 4 0 JNK-interacting protein leucine zipper II NRBF2 PF08961.8 001283872.1_29524001_3 - 1.6 8.2 14.1 0.59 9.6 2.7 2.7 2 0 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator AIM5 PF17050.3 001283872.1_29524001_3 - 2.4 8.4 4.8 20 5.4 0.7 3.3 4 0 0 4 4 4 0 Altered inheritance of mitochondria 5 p450 PF00067.20 001281653.1_31324001_1 - 1.1e-164 548.5 0.0 1.3e-164 548.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Glutaminase PF04960.13 001280796.1_26226001_1 - 1.9e-62 210.9 0.4 2.7e-62 210.4 0.4 1.1 1 0 0 1 1 1 1 Glutaminase Ank_2 PF12796.5 001280796.1_26226001_1 - 1.4e-12 47.9 0.0 2.9e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001280796.1_26226001_1 - 3.8e-10 40.0 0.1 2.1e-09 37.6 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.4 001280796.1_26226001_1 - 5.7e-08 32.8 0.1 2.3e-05 24.5 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.28 001280796.1_26226001_1 - 2.1e-05 24.6 0.0 0.002 18.4 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.4 001280796.1_26226001_1 - 0.00011 22.2 0.0 0.001 19.2 0.0 2.6 3 0 0 3 3 3 1 Ankyrin repeat Glutaminase PF04960.13 001280796.1_26226001_3 - 3.7e-44 150.9 0.0 5e-44 150.5 0.0 1.1 1 0 0 1 1 1 1 Glutaminase IPP-2 PF04979.12 001283605.1_29522001_2 - 6.8e-24 84.9 8.3 6.8e-24 84.9 8.3 1.6 2 0 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) Acetyltransf_2 PF00797.15 001281821.1_31323001_2 - 9.2e-88 293.9 0.3 1.1e-87 293.7 0.3 1.1 1 0 0 1 1 1 1 N-acetyltransferase Imm26 PF15428.4 001281821.1_31323001_2 - 0.14 12.3 0.1 0.34 11.0 0.1 1.6 1 0 0 1 1 1 0 Immunity protein 26 p450 PF00067.20 001281575.1_31324001_1 - 9.2e-164 545.4 0.0 1.1e-163 545.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_C14 PF00656.20 001281582.1_31325001_1 - 1.5e-53 182.2 0.1 2.1e-53 181.7 0.1 1.2 1 0 0 1 1 1 1 Caspase domain zf-C4 PF00105.16 001190391.1_39523001_1 - 1.8e-30 105.0 15.9 3.5e-30 104.1 15.9 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001190391.1_39523001_1 - 3e-18 66.0 0.3 8.8e-18 64.5 0.1 1.8 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor Peptidase_M2 PF01401.16 001281581.1_31329001_2 - 0 1723.4 9.2 1.3e-262 872.5 1.5 2.0 2 0 0 2 2 2 2 Angiotensin-converting enzyme L6_membrane PF05805.10 001281413.1_31323001_3 - 4.9e-70 234.9 15.6 6.3e-70 234.5 15.6 1.1 1 0 0 1 1 1 1 L6 membrane protein FHA PF00498.24 001082348.2_37929001_1 - 6.1e-17 61.6 0.0 1.5e-16 60.4 0.0 1.7 1 0 0 1 1 1 1 FHA domain Fib_alpha PF08702.8 001082348.2_37929001_1 - 0.0017 18.4 12.1 0.0017 18.4 12.1 5.7 2 2 5 7 7 7 3 Fibrinogen alpha/beta chain family Reo_sigmaC PF04582.10 001082348.2_37929001_1 - 3.1 7.0 28.2 0.064 12.5 4.4 3.9 2 2 2 4 4 4 0 Reovirus sigma C capsid protein MHC_I PF00129.16 001279551.1_24223001_1 - 7.7e-93 308.9 2.0 1.1e-92 308.4 2.0 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001279551.1_24223001_1 - 5.3e-17 61.9 0.1 1.3e-16 60.6 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001279551.1_24223001_1 - 4.4e-16 58.4 9.6 8e-16 57.5 9.6 1.5 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 001279551.1_24223001_1 - 1.9e-06 28.2 1.9 0.0063 17.0 0.1 3.0 1 1 1 2 2 2 2 Immunoglobulin domain DUF202 PF02656.13 001279551.1_24223001_1 - 0.0014 18.9 0.2 0.48 10.8 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF202) ig PF00047.23 001279551.1_24223001_1 - 0.0018 18.2 0.4 0.0038 17.2 0.4 1.6 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.10 001279551.1_24223001_1 - 0.0043 17.0 0.4 0.0043 17.0 0.4 1.7 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain MHC_I_3 PF16497.3 001279551.1_24223001_1 - 0.031 13.6 0.0 0.045 13.1 0.0 1.3 1 0 0 1 1 1 0 MHC-I family domain DUF2755 PF10954.6 001279551.1_24223001_1 - 0.16 11.8 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2755) p450 PF00067.20 001204438.1_08024001_1 - 4.3e-128 427.8 0.0 4.9e-128 427.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Aldo_ket_red PF00248.19 001170956.1_37924001_1 - 1.1e-70 237.9 0.0 1.4e-70 237.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family zf-C2H2 PF00096.24 001040424.2_26229001_1 - 2.7e-40 134.5 133.5 1.5e-05 25.1 1.1 17.9 17 0 0 17 17 17 15 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001040424.2_26229001_1 - 7.7e-40 132.0 128.9 0.0015 19.1 0.5 18.3 18 0 0 18 18 18 16 C2H2-type zinc finger zf-H2C2_2 PF13465.4 001040424.2_26229001_1 - 6.3e-26 89.5 111.6 2.5e-05 24.4 0.5 17.2 17 0 0 17 17 17 10 Zinc-finger double domain zf-C2H2_jaz PF12171.6 001040424.2_26229001_1 - 2.2e-13 50.0 93.0 0.011 15.9 0.1 17.0 18 0 0 18 18 18 8 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 001040424.2_26229001_1 - 9.9e-11 41.5 104.4 0.1 12.9 0.4 16.7 17 0 0 17 17 17 10 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.4 001040424.2_26229001_1 - 0.0033 17.2 39.6 0.049 13.4 0.2 9.7 9 0 0 9 9 9 3 zinc-finger of a C2HC-type SET PF00856.26 001040424.2_26229001_1 - 0.009 16.3 0.0 0.038 14.2 0.0 2.0 2 0 0 2 2 2 1 SET domain GAGA PF09237.9 001040424.2_26229001_1 - 0.068 12.9 2.8 17 5.2 0.2 3.9 3 0 0 3 3 3 0 GAGA factor BolA PF01722.16 001040424.2_26229001_1 - 3.2 8.0 11.4 88 3.4 0.1 5.7 5 2 1 6 6 6 0 BolA-like protein UQ_con PF00179.24 001281407.1_31323001_3 - 3.4e-46 156.3 0.0 4.4e-46 155.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.4 001281407.1_31323001_3 - 0.0018 17.8 0.0 0.0026 17.3 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B Acetyltransf_2 PF00797.15 001281823.1_31322001_2 - 4.6e-95 317.8 0.2 5.4e-95 317.6 0.2 1.0 1 0 0 1 1 1 1 N-acetyltransferase Imm26 PF15428.4 001281823.1_31322001_2 - 0.0053 16.8 0.3 0.013 15.6 0.1 1.8 2 0 0 2 2 2 1 Immunity protein 26 G-alpha PF00503.18 001281941.1_31324001_2 - 2.8e-105 352.2 0.1 3.6e-105 351.9 0.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 001281941.1_31324001_2 - 5.4e-16 58.4 2.7 3.3e-13 49.3 0.5 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001281941.1_31324001_2 - 0.0001 21.6 2.7 0.0016 17.7 0.2 2.4 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Roc PF08477.11 001281941.1_31324001_2 - 0.00057 20.0 1.4 0.1 12.7 0.2 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.4 001281941.1_31324001_2 - 0.087 12.4 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.25 001281941.1_31324001_2 - 0.096 12.1 0.1 0.9 8.9 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain ABC_membrane PF00664.21 001284171.1_29529001_3 - 2.6e-101 338.8 25.4 2.6e-56 191.1 4.7 2.5 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 001284171.1_29529001_3 - 8.4e-53 178.4 0.0 1.9e-28 99.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 001284171.1_29529001_3 - 2.8e-09 36.6 0.0 9.5e-05 21.8 0.0 3.7 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain PHO4 PF01384.18 001284171.1_29529001_3 - 9.9e-06 24.7 0.0 0.00022 20.3 0.0 3.0 2 2 1 3 3 3 1 Phosphate transporter family AAA_16 PF13191.4 001284171.1_29529001_3 - 1.1e-05 25.7 0.2 0.02 15.2 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.21 001284171.1_29529001_3 - 1.5e-05 24.9 0.5 0.15 12.1 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase DUF258 PF03193.14 001284171.1_29529001_3 - 0.00012 22.0 0.1 0.049 13.4 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_21 PF13304.4 001284171.1_29529001_3 - 0.00027 20.7 0.3 2.6 7.6 0.1 3.6 3 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.4 001284171.1_29529001_3 - 0.00034 20.1 0.5 0.017 14.5 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.4 001284171.1_29529001_3 - 0.00083 18.9 1.9 0.28 10.8 0.0 3.0 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_22 PF13401.4 001284171.1_29529001_3 - 0.0013 18.9 0.8 0.6 10.3 0.0 3.3 2 1 0 2 2 2 1 AAA domain ABC_ATPase PF09818.7 001284171.1_29529001_3 - 0.0049 15.6 0.5 0.29 9.7 0.0 2.8 3 1 0 3 3 3 1 Predicted ATPase of the ABC class Zeta_toxin PF06414.10 001284171.1_29529001_3 - 0.0073 15.5 1.2 0.037 13.2 0.1 2.2 2 0 0 2 2 2 1 Zeta toxin AAA_23 PF13476.4 001284171.1_29529001_3 - 0.02 15.3 0.3 8.6 6.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.15 001284171.1_29529001_3 - 0.05 13.5 2.0 4 7.3 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function DUF87 Dynamin_N PF00350.21 001284171.1_29529001_3 - 0.075 13.0 3.0 0.23 11.4 0.2 2.4 2 0 0 2 2 2 0 Dynamin family Roc PF08477.11 001284171.1_29529001_3 - 0.098 12.8 0.5 29 4.8 0.0 3.1 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.20 001284171.1_29529001_3 - 0.1 11.5 0.5 3.4 6.5 0.0 2.7 3 0 0 3 3 3 0 NB-ARC domain DUF2371 PF10177.7 001284171.1_29529001_3 - 0.11 12.5 0.0 0.72 9.9 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) DUF815 PF05673.11 001284171.1_29529001_3 - 0.21 10.6 0.5 3.5 6.6 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) COX4 PF02936.12 001251915.1_39722001_1 - 1.3e-58 196.8 2.4 1.5e-58 196.5 2.4 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV adh_short PF00106.23 001281353.1_31323001_1 - 6.9e-50 169.1 3.1 8.6e-50 168.8 3.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.4 001281353.1_31323001_1 - 5.8e-25 88.1 1.0 7.1e-25 87.8 1.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 001281353.1_31323001_1 - 9.7e-09 35.2 2.5 2.5e-08 33.9 2.5 1.8 1 1 0 1 1 1 1 KR domain DUF1776 PF08643.8 001281353.1_31323001_1 - 0.00012 21.5 0.0 0.00019 20.8 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) THF_DHG_CYH_C PF02882.17 001281353.1_31323001_1 - 0.0033 16.6 0.0 0.0059 15.8 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 2-Hacid_dh_C PF02826.17 001281353.1_31323001_1 - 0.038 13.2 0.0 0.064 12.5 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.12 001281353.1_31323001_1 - 0.055 12.6 0.0 0.082 12.0 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.18 001281353.1_31323001_1 - 0.064 13.2 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TNF PF00229.16 001257261.1_08022001_2 - 3.6e-39 133.5 0.0 5.1e-39 133.0 0.0 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family Lipase PF00151.17 001172978.1_09924001_2 - 3e-128 427.7 0.1 4.3e-128 427.2 0.1 1.1 1 0 0 1 1 1 1 Lipase PLAT PF01477.21 001172978.1_09924001_2 - 7.2e-25 87.7 1.0 1.3e-24 86.9 1.0 1.4 1 0 0 1 1 1 1 PLAT/LH2 domain Abhydrolase_6 PF12697.5 001172978.1_09924001_2 - 3.3e-05 24.5 0.2 4.5e-05 24.1 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.18 001172978.1_09924001_2 - 5e-05 22.9 0.0 7.6e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold RVT_1 PF00078.25 001172978.1_09924001_2 - 0.00038 19.9 0.1 0.00072 19.0 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Longin PF13774.4 001257243.1_08021001_1 - 0.028 14.3 0.0 0.038 13.9 0.0 1.4 1 1 0 1 1 1 0 Regulated-SNARE-like domain Oxidored_q6 PF01058.20 001279585.1_24222001_1 - 5.2e-24 84.4 0.1 7.6e-24 83.9 0.1 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Ammonium_transp PF00909.19 001279597.1_24223001_1 - 9.6e-64 215.4 27.7 1.2e-63 215.1 27.7 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family AzlD PF05437.10 001279597.1_24223001_1 - 0.0055 16.7 4.3 0.0055 16.7 4.3 2.8 2 1 0 2 2 2 1 Branched-chain amino acid transport protein (AzlD) Cation_efflux PF01545.19 001283952.1_29524001_1 - 8.3e-45 152.8 1.0 6e-40 137.0 0.0 2.1 2 0 0 2 2 2 2 Cation efflux family ZT_dimer PF16916.3 001283952.1_29524001_1 - 0.068 13.2 0.2 0.14 12.2 0.2 1.4 1 0 0 1 1 1 0 Dimerisation domain of Zinc Transporter Carb_anhydrase PF00194.19 001283272.1_29524001_2 - 5.7e-66 222.5 0.1 7.5e-66 222.1 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase p450 PF00067.20 001281583.1_31324001_3 - 3.6e-142 474.3 3.0 4.1e-142 474.1 3.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 P5CR_dimer PF14748.4 001284093.1_29525001_2 - 5.5e-35 119.6 1.9 9.7e-35 118.8 1.9 1.4 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.15 001284093.1_29525001_2 - 2.9e-15 56.5 1.1 3.9e-15 56.1 0.3 1.7 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Rossmann-like PF10727.7 001284093.1_29525001_2 - 0.0052 16.5 2.4 0.011 15.4 2.4 1.5 1 0 0 1 1 1 1 Rossmann-like domain DapB_N PF01113.18 001284093.1_29525001_2 - 0.14 12.1 0.1 0.25 11.4 0.1 1.3 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Metallothio PF00131.18 001281882.1_31321001_2 - 1.1e-19 70.1 65.3 1.4e-19 69.8 65.3 1.1 1 0 0 1 1 1 1 Metallothionein Rib_recp_KP_reg PF05104.10 001281882.1_31321001_3 - 2.9 8.8 9.9 3.6 8.5 9.9 1.1 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region NAD_binding_5 PF07994.10 001283602.1_29524001_3 - 2.5e-138 460.7 0.0 3.2e-138 460.4 0.0 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.15 001283602.1_29524001_3 - 7.9e-46 154.7 0.0 7.9e-46 154.7 0.0 2.2 2 0 0 2 2 2 1 Myo-inositol-1-phosphate synthase Pyrophosphatase PF00719.17 001283771.1_29523001_2 - 3e-60 202.5 0.6 4e-60 202.1 0.6 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase DUF4523 PF15023.4 001283900.1_29524001_2 - 2.2e-93 310.5 1.4 2.2e-93 310.5 1.4 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF4523) DUF3591 PF12157.6 001281569.1_31329001_1 - 3.2e-165 550.0 0.0 1.6e-164 547.6 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3591) Bromodomain PF00439.23 001281569.1_31329001_1 - 1.3e-41 140.4 4.1 2.4e-21 75.5 0.5 2.7 2 0 0 2 2 2 2 Bromodomain TBP-binding PF09247.9 001281569.1_31329001_1 - 4.3e-22 78.0 2.8 1.3e-21 76.5 2.8 1.8 1 0 0 1 1 1 1 TATA box-binding protein binding zf-CCHC_6 PF15288.4 001281569.1_31329001_1 - 1.7e-15 56.4 0.3 4.1e-15 55.2 0.3 1.6 1 0 0 1 1 1 1 Zinc knuckle P53 PF00870.16 001281661.1_31325001_1 - 2.8e-111 369.6 0.6 3.8e-111 369.2 0.6 1.2 1 0 0 1 1 1 1 P53 DNA-binding domain P53_tetramer PF07710.9 001281661.1_31325001_1 - 4.8e-15 54.5 1.1 8.5e-15 53.7 1.1 1.4 1 0 0 1 1 1 1 P53 tetramerisation motif P53_TAD PF08563.9 001281661.1_31325001_1 - 1.5e-11 43.2 4.4 1.5e-11 43.2 4.4 1.9 2 0 0 2 2 2 1 P53 transactivation motif Abhydrolase_6 PF12697.5 145215.2_32923001_3 - 1.3e-22 81.3 0.3 1.3e-22 81.3 0.3 1.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.18 145215.2_32923001_3 - 8.2e-22 77.9 0.2 6.5e-16 58.6 0.1 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 145215.2_32923001_3 - 1.7e-15 56.8 0.1 4.8e-15 55.4 0.1 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.11 145215.2_32923001_3 - 1.4e-06 28.1 0.6 0.00078 19.1 0.6 2.2 1 1 0 1 1 1 1 PGAP1-like protein Thioesterase PF00975.18 145215.2_32923001_3 - 7.7e-06 26.0 0.0 1.2e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Esterase PF00756.18 145215.2_32923001_3 - 8.1e-06 25.5 0.0 0.00022 20.8 0.0 2.2 1 1 0 1 1 1 1 Putative esterase Lipase_3 PF01764.23 145215.2_32923001_3 - 0.001 18.8 0.0 0.0019 17.9 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Chlorophyllase2 PF12740.5 145215.2_32923001_3 - 0.0064 15.3 0.0 0.013 14.3 0.0 1.5 1 1 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.9 145215.2_32923001_3 - 0.031 13.2 0.1 0.068 12.0 0.1 1.5 1 1 0 1 1 1 0 Chlorophyllase PAF-AH_p_II PF03403.11 145215.2_32923001_3 - 0.052 11.9 0.0 0.53 8.6 0.0 2.0 1 1 1 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II Ndr PF03096.12 145215.2_32923001_3 - 0.065 11.8 0.0 0.22 10.1 0.0 1.8 1 1 0 1 1 1 0 Ndr family DUF915 PF06028.9 145215.2_32923001_3 - 0.24 10.5 0.0 13 4.9 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) RRM_1 PF00076.20 001185043.1_08023001_2 - 8.5e-14 51.0 0.5 1.4e-13 50.3 0.5 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001185043.1_08023001_2 - 0.0046 16.9 0.2 0.016 15.2 0.2 1.9 1 1 0 1 1 1 1 RNA recognition motif p450 PF00067.20 001204440.1_08024001_3 - 6.5e-131 437.1 0.1 7.4e-131 436.9 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 7tm_1 PF00001.19 001282528.1_39522001_1 - 2e-33 115.6 24.8 1.5e-31 109.5 24.8 2.2 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001282528.1_39522001_1 - 6.1e-15 55.6 13.1 2e-13 50.6 10.4 2.6 2 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001282528.1_39522001_1 - 7e-09 35.3 18.4 1e-07 31.5 18.4 2.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001282528.1_39522001_1 - 0.32 10.1 20.7 0.016 14.4 13.1 2.2 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx GST_C_3 PF14497.4 001171098.2_37922001_1 - 3.2e-19 68.8 0.0 5e-19 68.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.18 001171098.2_37922001_1 - 7.4e-19 67.7 0.0 2.8e-18 65.9 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 001171098.2_37922001_1 - 3.7e-17 62.2 0.0 6e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 001171098.2_37922001_1 - 0.0056 16.9 0.0 0.013 15.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Gp_dh_C PF02800.18 001284052.1_29523001_1 - 2.2e-69 232.0 0.0 3e-69 231.5 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.22 001284052.1_29523001_1 - 1.6e-35 121.3 0.0 2.8e-35 120.6 0.0 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.17 001284052.1_29523001_1 - 0.00022 20.5 0.0 0.00035 19.8 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3Beta_HSD PF01073.17 001281397.1_31324001_1 - 1.4e-100 335.8 0.0 1.8e-100 335.4 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 001281397.1_31324001_1 - 8.9e-25 87.4 0.0 1.2e-24 87.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.10 001281397.1_31324001_1 - 5.2e-19 68.3 0.1 1e-18 67.3 0.1 1.5 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.3 001281397.1_31324001_1 - 1.3e-13 50.9 0.1 9.6e-13 48.1 0.0 1.9 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.4 001281397.1_31324001_1 - 1.7e-11 44.2 0.1 3e-11 43.5 0.0 1.4 2 0 0 2 2 2 1 NAD(P)H-binding Polysacc_synt_2 PF02719.13 001281397.1_31324001_1 - 1.2e-09 37.6 0.1 2.3e-09 36.7 0.0 1.4 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NmrA PF05368.11 001281397.1_31324001_1 - 2.6e-08 33.6 0.0 3.9e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.15 001281397.1_31324001_1 - 2.7e-08 33.1 0.0 4.3e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.8 001281397.1_31324001_1 - 7.6e-06 25.8 0.1 1.7e-05 24.7 0.1 1.5 1 1 0 1 1 1 1 KR domain Semialdhyde_dh PF01118.22 001281397.1_31324001_1 - 0.092 13.1 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain zf-RING_4 PF14570.4 001281397.1_31324001_1 - 0.22 11.2 1.6 0.51 10.0 1.6 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain TMCO5 PF14992.4 001283077.1_29523001_1 - 9.2e-70 235.2 12.4 1.2e-69 234.9 12.4 1.1 1 0 0 1 1 1 1 TMCO5 family UBA PF00627.29 001283377.1_29525001_2 - 1.9e-11 43.5 0.6 1.9e-11 43.5 0.6 1.7 2 0 0 2 2 2 1 UBA/TS-N domain Rhomboid PF01694.20 001283377.1_29525001_2 - 0.046 13.6 3.7 0.082 12.7 3.7 1.5 1 0 0 1 1 1 0 Rhomboid family DER1 PF04511.13 001283377.1_29525001_2 - 0.097 12.2 6.1 0.16 11.6 6.1 1.3 1 0 0 1 1 1 0 Der1-like family Kelch_3 PF13415.4 145522.4_32924001_1 - 2.5e-31 107.2 14.2 1.2e-07 31.7 0.0 6.7 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_4 PF13418.4 145522.4_32924001_1 - 4.7e-30 103.2 5.3 3.5e-06 26.8 0.0 6.9 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_5 PF13854.4 145522.4_32924001_1 - 2.5e-28 97.4 10.9 2e-05 24.3 0.0 7.0 7 0 0 7 7 7 6 Kelch motif Kelch_6 PF13964.4 145522.4_32924001_1 - 3.5e-28 96.8 4.7 1.1e-05 25.3 0.0 6.3 3 1 3 6 6 6 5 Kelch motif Kelch_2 PF07646.13 145522.4_32924001_1 - 2.3e-27 93.7 11.1 2.3e-14 52.6 0.0 6.7 6 1 0 6 6 6 5 Kelch motif Kelch_1 PF01344.23 145522.4_32924001_1 - 2.1e-26 91.1 1.8 4.1e-06 26.1 0.0 6.2 6 0 0 6 6 6 5 Kelch motif Actin PF00022.17 001283924.1_29523001_2 - 4.3e-112 374.6 0.0 7.3e-111 370.5 0.0 1.9 1 1 0 1 1 1 1 Actin Filament PF00038.19 001285719.1_09024001_2 - 5.2e-101 338.2 19.2 6.4e-101 337.9 19.2 1.1 1 0 0 1 1 1 1 Intermediate filament protein ATG16 PF08614.9 001285719.1_09024001_2 - 0.0078 16.3 24.8 0.36 10.8 0.4 3.9 3 1 1 4 4 4 3 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.10 001285719.1_09024001_2 - 0.019 14.9 26.3 0.04 13.9 1.5 3.7 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein DUF1664 PF07889.10 001285719.1_09024001_2 - 1.7 8.6 12.2 1.2 9.0 0.5 4.3 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) V_ATPase_I PF01496.17 001285719.1_09024001_2 - 2.5 5.8 8.3 0.35 8.6 3.4 1.8 1 1 0 2 2 2 0 V-type ATPase 116kDa subunit family SlyX PF04102.10 001285719.1_09024001_2 - 2.8 8.5 14.0 68 4.1 0.1 4.6 3 1 2 5 5 5 0 SlyX DUF4446 PF14584.4 001285719.1_09024001_2 - 2.8 7.8 8.1 5.2 6.9 0.0 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF4446) IncA PF04156.12 001285719.1_09024001_2 - 2.8 7.6 23.7 1.8e+02 1.7 0.0 3.8 2 1 1 3 3 2 0 IncA protein Reo_sigmaC PF04582.10 001285719.1_09024001_2 - 3.5 6.8 12.1 0.46 9.7 2.4 2.6 2 1 0 3 3 3 0 Reovirus sigma C capsid protein FlxA PF14282.4 001285719.1_09024001_2 - 4.4 7.2 20.2 0.046 13.6 5.6 3.7 2 2 2 4 4 4 0 FlxA-like protein Prefoldin_2 PF01920.18 001285719.1_09024001_2 - 4.8 7.1 19.0 55 3.7 0.8 4.7 3 1 0 3 3 3 0 Prefoldin subunit DUF724 PF05266.12 001285719.1_09024001_2 - 5 6.8 10.5 1.7 8.3 3.3 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF724) DUF4140 PF13600.4 001285719.1_09024001_2 - 5.9 7.3 13.2 66 3.9 0.4 4.4 3 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) RasGAP_C PF03836.13 001285719.1_09024001_2 - 7.3 6.6 16.4 2.9 7.9 1.4 3.6 2 1 2 4 4 4 0 RasGAP C-terminus DUF4407 PF14362.4 001285719.1_09024001_2 - 8.4 5.5 18.0 4.3 6.5 0.9 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) TIMP PF00965.15 001195682.1_37922001_1 - 1.7e-66 223.4 7.9 2e-66 223.2 7.9 1.0 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase TGF_beta PF00019.18 001285708.1_09023001_1 - 6.8e-27 94.3 0.3 1.3e-26 93.4 0.3 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain Serpin PF00079.18 001281953.1_31323001_2 - 8.8e-88 295.0 2.4 1e-87 294.8 2.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) LrgB PF04172.14 001281953.1_31323001_2 - 0.013 14.9 0.2 0.02 14.3 0.2 1.2 1 0 0 1 1 1 0 LrgB-like family Transposase_1 PF01359.16 001284731.1_29524001_1 - 0.00077 19.1 1.2 0.0015 18.2 1.2 1.4 1 0 0 1 1 1 1 Transposase (partial DDE domain) D123 PF07065.12 001284731.1_29524001_3 - 5e-105 350.9 1.1 5.8e-105 350.7 1.1 1.0 1 0 0 1 1 1 1 D123 DUF4343 PF14243.4 001284731.1_29524001_3 - 0.0013 18.8 0.0 0.0022 18.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4343) Lipoxygenase PF00305.17 001281587.1_31325001_1 - 4.3e-78 263.2 0.3 2.9e-76 257.2 0.0 2.1 1 1 1 2 2 2 2 Lipoxygenase PLAT PF01477.21 001281587.1_31325001_1 - 2.7e-25 89.1 0.3 6.8e-25 87.8 0.1 1.8 2 0 0 2 2 2 1 PLAT/LH2 domain CUB PF00431.18 001195762.1_37923001_1 - 8.9e-22 77.4 0.0 1.7e-21 76.5 0.0 1.5 1 0 0 1 1 1 1 CUB domain PDGF PF00341.15 001195762.1_37923001_1 - 1.6e-17 63.4 6.7 1.6e-17 63.4 6.7 1.7 2 0 0 2 2 2 1 PDGF/VEGF domain Cystatin PF00031.19 001172913.1_09923001_1 - 8.5e-21 73.9 0.0 1.9e-16 59.9 0.0 2.2 2 0 0 2 2 2 2 Cystatin domain Sulfate_transp PF00916.18 001195763.1_37924001_1 - 3.5e-94 315.5 23.4 4.8e-94 315.1 23.4 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.19 001195763.1_37924001_1 - 3.4e-18 65.2 0.2 8.2e-18 64.0 0.2 1.6 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.4 001195763.1_37924001_1 - 0.00029 21.0 0.0 0.00073 19.7 0.0 1.6 1 0 0 1 1 1 1 STAS domain Ribosomal_S3Ae PF01015.16 001283897.1_29522001_1 - 2.2e-107 357.2 8.8 2.6e-107 356.9 8.8 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.14 001283897.1_29522001_1 - 0.0062 16.0 0.2 0.027 13.9 0.0 2.2 1 1 1 2 2 2 1 Partial alpha/beta-hydrolase lipase region Trypsin PF00089.24 001281379.1_31323001_1 - 1.9e-53 181.4 0.0 2.5e-53 181.0 0.0 1.1 1 0 0 1 1 1 1 Trypsin E1_DerP2_DerF2 PF02221.13 001283562.1_29522001_3 - 1.6e-31 109.4 0.1 2.1e-31 109.0 0.1 1.1 1 0 0 1 1 1 1 ML domain DUF1091 PF06477.11 001283562.1_29522001_3 - 0.052 13.9 0.1 0.089 13.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1091) MFS_1 PF07690.14 001281327.1_31325001_2 - 5.1e-39 134.0 30.4 1.2e-36 126.3 27.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.22 001281327.1_31325001_2 - 0.002 17.0 7.6 0.002 17.0 7.6 2.9 2 1 0 2 2 2 2 Sugar (and other) transporter ISK_Channel PF02060.13 001281327.1_31325001_2 - 0.19 11.3 0.0 0.19 11.3 0.0 1.7 2 0 0 2 2 2 0 Slow voltage-gated potassium channel p450 PF00067.20 001281423.1_31326001_1 - 5.3e-104 348.4 0.0 6.8e-104 348.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Vps5 PF09325.8 001287672.1_29525001_3 - 4.9e-83 278.1 23.0 4.9e-83 278.1 23.0 1.5 2 0 0 2 2 2 1 Vps5 C terminal like PX PF00787.22 001287672.1_29525001_3 - 6.4e-28 96.9 0.0 1.5e-27 95.7 0.0 1.6 1 0 0 1 1 1 1 PX domain Sorting_nexin PF03700.11 001287672.1_29525001_3 - 1e-20 74.5 8.8 1e-20 74.5 8.8 1.7 2 0 0 2 2 2 1 Sorting nexin, N-terminal domain BAR_3_WASP_bdg PF10456.7 001287672.1_29525001_3 - 0.00022 20.6 4.8 0.0019 17.6 4.8 2.2 1 1 0 1 1 1 1 WASP-binding domain of Sorting nexin protein FUSC PF04632.10 001287672.1_29525001_3 - 0.87 7.9 7.4 1.3 7.4 7.4 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Arfaptin PF06456.11 001287672.1_29525001_3 - 4.2 6.7 13.7 23 4.3 13.7 2.1 1 1 0 1 1 1 0 Arfaptin-like domain Sod_Cu PF00080.18 001285550.1_09021001_1 - 2.4e-47 160.5 4.1 2.8e-47 160.3 4.1 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Apolipoprotein PF01442.16 001283745.1_29522001_3 - 2.9e-54 183.8 10.6 7.3e-54 182.5 10.8 1.5 2 0 0 2 2 1 1 Apolipoprotein A1/A4/E domain YtxH PF12732.5 001283745.1_29522001_3 - 4.2e-06 27.1 7.0 1.6 9.2 4.0 4.5 1 1 1 2 2 2 1 YtxH-like protein ApoLp-III PF07464.9 001283745.1_29522001_3 - 5.6e-05 23.1 2.1 0.047 13.7 1.1 3.1 1 1 2 3 3 3 1 Apolipophorin-III precursor (apoLp-III) Exonuc_VII_L PF02601.13 001283745.1_29522001_3 - 0.00012 21.6 3.6 0.00017 21.1 3.6 1.3 1 0 0 1 1 1 1 Exonuclease VII, large subunit DUF883 PF05957.11 001283745.1_29522001_3 - 0.00018 21.9 10.4 0.4 11.2 0.8 3.9 2 1 3 5 5 4 2 Bacterial protein of unknown function (DUF883) ApoC-I PF04691.10 001283745.1_29522001_3 - 0.00022 21.0 1.3 0.87 9.4 0.0 4.0 3 1 1 4 4 4 1 Apolipoprotein C-I (ApoC-1) DUF1640 PF07798.9 001283745.1_29522001_3 - 0.00023 21.2 1.5 0.00082 19.3 0.8 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF1640) DUF4455 PF14643.4 001283745.1_29522001_3 - 0.00043 19.0 8.7 0.0013 17.5 8.6 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4455) DHC_N1 PF08385.10 001283745.1_29522001_3 - 0.00062 18.4 0.1 0.00084 17.9 0.1 1.2 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 DUF948 PF06103.9 001283745.1_29522001_3 - 0.00092 19.3 0.1 0.13 12.4 0.1 3.1 1 1 0 2 2 2 1 Bacterial protein of unknown function (DUF948) Mating_N PF12731.5 001283745.1_29522001_3 - 0.0011 18.8 0.4 4.8 7.2 0.1 4.0 2 1 2 4 4 4 0 Mating-type protein beta 1 Gp-FAR-1 PF05823.10 001283745.1_29522001_3 - 0.0029 17.8 1.9 0.27 11.4 0.3 3.2 1 1 3 4 4 4 1 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Baculo_PEP_C PF04513.10 001283745.1_29522001_3 - 0.0065 16.4 0.1 4.3 7.2 0.0 3.0 1 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus ApoA-II PF04711.11 001283745.1_29522001_3 - 0.0069 16.4 2.7 0.16 12.0 0.1 3.8 2 2 1 4 4 4 1 Apolipoprotein A-II (ApoA-II) TipAS PF07739.11 001283745.1_29522001_3 - 0.007 16.8 6.3 1.7 9.1 2.2 2.9 1 1 1 2 2 2 1 TipAS antibiotic-recognition domain RRF PF01765.17 001283745.1_29522001_3 - 0.021 14.6 1.4 4.5 7.1 0.6 2.3 1 1 1 2 2 2 0 Ribosome recycling factor DUF2894 PF11445.6 001283745.1_29522001_3 - 0.021 15.1 7.4 0.47 10.8 2.5 2.6 1 1 1 3 3 3 0 Protein of unknown function (DUF2894) DUF1664 PF07889.10 001283745.1_29522001_3 - 0.024 14.5 0.8 0.28 11.0 0.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) BAR PF03114.16 001283745.1_29522001_3 - 0.024 14.1 3.6 0.28 10.7 1.0 2.2 1 1 1 2 2 2 0 BAR domain Gp58 PF07902.9 001283745.1_29522001_3 - 0.029 12.7 0.0 0.035 12.4 0.0 1.2 1 0 0 1 1 1 0 gp58-like protein OmpH PF03938.12 001283745.1_29522001_3 - 0.031 14.1 6.9 0.033 14.1 2.7 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DUF445 PF04286.10 001283745.1_29522001_3 - 0.033 13.9 3.2 0.7 9.5 0.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF445) ApoO PF09769.7 001283745.1_29522001_3 - 0.038 13.8 0.6 17 5.2 0.1 3.1 1 1 2 3 3 3 0 Apolipoprotein O DUF4795 PF16043.3 001283745.1_29522001_3 - 0.039 13.4 5.3 0.13 11.7 5.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) DUF4015 PF13200.4 001283745.1_29522001_3 - 0.074 11.9 0.1 0.28 10.1 0.1 1.8 2 0 0 2 2 2 0 Putative glycosyl hydrolase domain Phasin PF05597.9 001283745.1_29522001_3 - 0.099 12.5 4.3 0.61 10.0 1.6 3.0 1 1 3 4 4 4 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Mis14 PF08641.10 001283745.1_29522001_3 - 0.1 12.8 5.0 2.2 8.5 5.0 2.8 1 1 0 1 1 1 0 Kinetochore protein Mis14 like Prominin PF05478.9 001283745.1_29522001_3 - 0.1 10.4 0.2 0.44 8.3 0.2 1.7 1 1 1 2 2 2 0 Prominin Fzo_mitofusin PF04799.11 001283745.1_29522001_3 - 0.13 11.6 1.6 0.37 10.2 0.4 2.1 1 1 1 2 2 2 0 fzo-like conserved region BshC PF10079.7 001283745.1_29522001_3 - 0.14 10.8 5.6 0.23 10.0 3.9 1.8 1 1 1 2 2 2 0 Bacillithiol biosynthesis BshC LMP PF04778.10 001283745.1_29522001_3 - 0.16 11.8 1.0 0.31 10.8 0.5 1.7 2 0 0 2 2 2 0 LMP repeated region MIF4G_like_2 PF09090.9 001283745.1_29522001_3 - 0.16 11.2 5.5 10 5.4 5.5 2.1 1 1 0 1 1 1 0 MIF4G like DUF4407 PF14362.4 001283745.1_29522001_3 - 0.2 10.8 2.2 0.27 10.4 2.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) KMP11 PF03037.14 001283745.1_29522001_3 - 0.2 12.3 2.9 0.81 10.4 1.3 2.5 1 1 1 3 3 2 0 Kinetoplastid membrane protein 11 DUF641 PF04859.10 001283745.1_29522001_3 - 0.25 11.6 3.0 0.38 11.0 1.9 1.9 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) TBPIP PF07106.11 001283745.1_29522001_3 - 0.32 10.6 5.1 1.1 8.9 2.2 2.3 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF3618 PF12277.6 001283745.1_29522001_3 - 0.41 10.8 10.9 3.3 7.9 0.0 4.6 4 1 2 6 6 4 0 Protein of unknown function (DUF3618) HIP1_clath_bdg PF16515.3 001283745.1_29522001_3 - 0.53 10.8 10.2 0.29 11.6 5.0 2.6 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF1690 PF07956.9 001283745.1_29522001_3 - 0.55 10.5 8.6 3.3 8.0 3.1 2.7 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) Muted PF14942.4 001283745.1_29522001_3 - 0.56 10.4 5.9 0.9 9.7 3.5 2.2 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein TetR_C_6 PF13977.4 001283745.1_29522001_3 - 0.94 9.6 7.7 2.6 8.2 3.5 2.7 2 1 1 3 3 2 0 Bacterial transcriptional repressor MRP-S27 PF10037.7 001283745.1_29522001_3 - 1.2 7.8 7.3 0.6 8.8 3.8 1.9 1 1 1 2 2 2 0 Mitochondrial 28S ribosomal protein S27 FlgN PF05130.10 001283745.1_29522001_3 - 1.3 9.4 11.5 0.62 10.4 2.6 2.5 1 1 1 2 2 2 0 FlgN protein Nnf1 PF03980.12 001283745.1_29522001_3 - 2.1 8.6 9.1 19 5.5 3.6 3.5 2 1 0 2 2 2 0 Nnf1 YlqD PF11068.6 001283745.1_29522001_3 - 2.1 8.6 6.3 1.6 9.0 3.9 1.9 1 1 1 2 2 2 0 YlqD protein DUF1451 PF07295.9 001283745.1_29522001_3 - 2.3 8.1 6.3 1.7 8.6 2.9 2.1 1 1 1 2 2 2 0 Zinc-ribbon containing domain Prp19 PF08606.9 001283745.1_29522001_3 - 3.3 7.6 9.0 4.6 7.2 0.0 4.3 2 1 2 4 4 4 0 Prp19/Pso4-like Clathrin_lg_ch PF01086.15 001283745.1_29522001_3 - 5 7.0 9.8 26 4.7 0.0 3.1 2 1 0 3 3 3 0 Clathrin light chain Ank_2 PF12796.5 001172652.1_09926001_1 - 1.1e-16 61.0 0.6 2.1e-07 31.3 0.4 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ion_trans PF00520.29 001172652.1_09926001_1 - 3.5e-15 55.8 20.1 5e-15 55.3 20.1 1.2 1 0 0 1 1 1 1 Ion transport protein Ank PF00023.28 001172652.1_09926001_1 - 1.4e-10 41.0 2.2 0.0032 17.7 0.0 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.4 001172652.1_09926001_1 - 2.5e-10 39.6 0.2 0.02 15.2 0.0 4.7 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.4 001172652.1_09926001_1 - 2e-09 37.4 0.1 0.1 12.9 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 001172652.1_09926001_1 - 3.4e-07 30.6 0.7 0.015 15.7 0.0 4.5 2 1 2 4 4 4 3 Ankyrin repeats (many copies) CNOT1_HEAT PF16418.3 001172652.1_09926001_1 - 0.064 13.2 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 1 HEAT repeat Urm1 PF09138.9 001285664.1_09021001_1 - 3.6e-39 132.9 0.0 4.1e-39 132.7 0.0 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.18 001285664.1_09021001_1 - 0.0014 19.1 0.0 0.0017 18.8 0.0 1.2 1 0 0 1 1 1 1 ThiS family Transglut_core PF01841.17 001280499.1_39727001_1 - 0.0053 17.1 0.0 0.017 15.4 0.0 1.8 1 0 0 1 1 1 1 Transglutaminase-like superfamily Ribosomal_L16 PF00252.16 001285230.1_29524001_2 - 3.4e-43 146.7 0.3 3.4e-43 146.7 0.3 2.0 2 0 0 2 2 2 1 Ribosomal protein L16p/L10e Sugar_tr PF00083.22 001284036.1_29527001_1 - 1.2e-31 110.0 22.1 6.5e-28 97.6 7.3 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.14 001284036.1_29527001_1 - 1.9e-31 109.2 33.9 1.8e-22 79.6 16.3 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Pentapeptide_4 PF13599.4 001284036.1_29527001_1 - 4.2e-07 29.9 7.2 7.3e-07 29.1 7.2 1.3 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) MFS_2 PF13347.4 001284036.1_29527001_1 - 0.0016 16.9 11.2 0.0016 16.9 11.2 2.5 2 0 0 2 2 2 1 MFS/sugar transport protein MFS_4 PF06779.12 001284036.1_29527001_1 - 0.0031 16.8 9.8 0.0031 16.8 9.8 2.3 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Pentapeptide PF00805.20 001284036.1_29527001_1 - 0.018 14.6 0.7 0.036 13.6 0.5 1.6 1 1 0 1 1 1 0 Pentapeptide repeats (8 copies) Pentapeptide_3 PF13576.4 001284036.1_29527001_1 - 0.019 14.9 9.0 1.3 9.1 4.9 2.4 1 1 0 2 2 2 0 Pentapeptide repeats (9 copies) TMEM210 PF15195.4 001284036.1_29527001_1 - 0.048 14.0 0.2 0.11 12.8 0.2 1.5 1 0 0 1 1 1 0 TMEM210 family MFS_3 PF05977.11 001284036.1_29527001_1 - 0.12 10.5 8.0 0.29 9.3 3.5 2.1 2 0 0 2 2 2 0 Transmembrane secretion effector MraY_sig1 PF10555.7 001284036.1_29527001_2 - 3.8 7.1 5.6 3.3 7.3 1.2 2.7 2 0 0 2 2 2 0 Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 p450 PF00067.20 001190431.1_37924001_2 - 3.6e-160 533.6 0.1 4.1e-160 533.4 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 7tm_1 PF00001.19 001281694.1_31325001_3 - 4.4e-79 265.3 6.6 7.5e-79 264.6 6.6 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001281694.1_31325001_3 - 5.2e-15 55.4 6.4 9.8e-15 54.5 6.4 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001281694.1_31325001_3 - 6.1e-07 29.3 5.2 1.4e-05 24.9 4.0 2.2 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.7 001281694.1_31325001_3 - 2.8e-05 23.5 8.6 5.1e-05 22.6 8.6 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.7 001281694.1_31325001_3 - 0.002 17.4 0.7 0.002 17.4 0.7 1.8 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv WD40 PF00400.30 001272100.1_43524001_2 - 2.3e-09 37.6 4.2 1.7 9.5 0.1 6.6 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001272100.1_43524001_2 - 0.00057 20.0 0.1 4.2 7.6 0.0 4.2 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ribosomal_L18 PF17135.2 001285384.1_29522001_3 - 2.8e-95 316.9 4.1 3.2e-95 316.7 4.1 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.17 001285384.1_29522001_3 - 0.076 13.6 0.0 0.14 12.8 0.0 1.5 1 1 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Actin PF00022.17 001283710.1_29524001_1 - 2.9e-100 335.6 3.2 2.6e-99 332.5 0.0 2.7 2 1 0 2 2 2 1 Actin ACTL7A_N PF16840.3 001283710.1_29524001_1 - 5.9e-34 115.8 5.2 5.9e-34 115.8 5.2 2.1 2 0 0 2 2 2 1 Actin-like protein 7A N-terminus MreB_Mbl PF06723.11 001283710.1_29524001_1 - 1.9e-05 23.5 0.0 0.051 12.3 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein 7tm_1 PF00001.19 001283710.1_29524001_1 - 3.8 6.5 5.8 6.1 5.9 5.8 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) EIIBC-GUT_N PF03612.12 001283710.1_29524001_1 - 7.1 6.2 9.7 10 5.7 8.0 2.0 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus SR-25 PF10500.7 001283710.1_29524001_3 - 0.26 10.7 35.7 0.35 10.3 35.7 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Aldo_ket_red PF00248.19 001283699.1_29523001_2 - 7.6e-54 182.7 0.0 9.2e-54 182.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Mpv17_PMP22 PF04117.10 001289561.1_32927001_1 - 2.3e-10 40.4 4.4 2.3e-10 40.4 4.4 2.1 2 0 0 2 2 2 1 Mpv17 / PMP22 family RRM_1 PF00076.20 001283741.1_29525001_2 - 1.2e-26 92.2 0.0 2e-11 43.4 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF PF08080.10 001283741.1_29525001_2 - 3.5e-22 77.9 9.1 4.2e-22 77.7 7.9 1.8 2 0 0 2 2 2 1 RNPHF zinc finger RRM_3 PF08777.9 001283741.1_29525001_2 - 0.0026 17.6 0.0 5.6 6.9 0.0 3.2 3 0 0 3 3 3 2 RNA binding motif Spot_14 PF07084.10 001283741.1_29525001_2 - 0.12 12.4 0.0 1.4 8.9 0.0 2.1 2 0 0 2 2 2 0 Thyroid hormone-inducible hepatic protein Spot 14 Med21 PF11221.6 001284102.1_29524001_2 - 7.2e-26 91.0 1.4 1.3e-25 90.2 1.4 1.4 1 0 0 1 1 1 1 Subunit 21 of Mediator complex PCNA_C PF02747.13 001287720.1_29523001_3 - 8.1e-63 210.2 0.0 1.4e-62 209.4 0.0 1.4 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, C-terminal domain PCNA_N PF00705.16 001287720.1_29523001_3 - 5.6e-60 200.5 2.1 1e-59 199.6 2.1 1.4 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain Rad1 PF02144.14 001287720.1_29523001_3 - 1.4e-09 37.3 0.2 3.5e-09 36.0 0.2 1.5 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.11 001287720.1_29523001_3 - 2.6e-07 30.2 0.1 3.6e-07 29.8 0.1 1.2 1 0 0 1 1 1 1 Rad9 Hus1 PF04005.10 001287720.1_29523001_3 - 0.05 12.6 0.0 0.14 11.1 0.0 1.7 1 1 1 2 2 2 0 Hus1-like protein 7tm_1 PF00001.19 175490.4_32926001_3 - 5.1e-17 61.9 16.7 7.7e-17 61.3 16.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Thyroglobulin_1 PF00086.16 001195105.1_49822001_2 - 1e-22 79.4 2.9 1.7e-22 78.7 2.9 1.4 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat IGFBP PF00219.16 001195105.1_49822001_2 - 7.3e-08 32.8 21.3 7.3e-08 32.8 21.3 2.2 2 0 0 2 2 2 1 Insulin-like growth factor binding protein DUF1566 PF07603.9 001195105.1_49822001_2 - 0.16 12.2 0.1 0.21 11.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1566) Tubulin PF00091.23 001285304.1_29525001_1 - 1.6e-60 204.6 0.4 2.2e-60 204.1 0.4 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.4 001285304.1_29525001_1 - 0.00016 20.9 0.0 0.00026 20.2 0.0 1.2 1 0 0 1 1 1 1 Tubulin like EBP50_C PF09007.9 001285180.1_29525001_1 - 6.1e-43 146.8 9.3 6.1e-43 146.8 9.3 1.8 2 0 0 2 2 2 1 EBP50, C-terminal PDZ PF00595.22 001285180.1_29525001_1 - 9.9e-30 102.6 0.0 2e-13 50.4 0.0 2.4 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001285180.1_29525001_1 - 2.3e-15 56.5 0.1 8.1e-07 29.1 0.0 2.4 2 0 0 2 2 2 2 PDZ domain GRASP55_65 PF04495.12 001285180.1_29525001_1 - 0.00086 19.5 0.0 1.1 9.5 0.0 2.2 2 0 0 2 2 2 2 GRASP55/65 PDZ-like domain ODC_AZ PF02100.15 001281321.2_31323001_3 - 7.7e-21 74.1 0.0 1.2e-20 73.4 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme 7tm_1 PF00001.19 001285152.1_29526001_2 - 2.2e-30 105.7 19.3 3.3e-30 105.1 18.8 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Lectin_C PF00059.19 001281884.1_31329001_2 - 1.1e-137 450.6 46.9 2e-18 67.0 0.4 10.8 10 0 0 10 10 10 10 Lectin C-type domain fn2 PF00040.17 001281884.1_31329001_2 - 2.1e-14 53.4 4.4 9.1e-14 51.3 4.4 2.3 1 0 0 1 1 1 1 Fibronectin type II domain UL45 PF05473.10 001281884.1_31329001_2 - 1.6e-11 44.1 13.6 0.14 11.7 0.0 9.3 10 1 1 11 11 11 3 UL45 protein, carbohydrate-binding C-type lectin-like Xlink PF00193.15 001281884.1_31329001_2 - 7.7e-06 26.1 8.6 1 9.6 0.0 7.7 8 0 0 8 8 8 1 Extracellular link domain Chordopox_A33R PF05966.10 001281884.1_31329001_2 - 6.4e-05 22.2 11.1 0.011 14.8 0.3 5.3 7 0 0 7 7 7 3 Chordopoxvirus A33R protein Acylphosphatase PF00708.16 001190198.1_49822001_2 - 3.7e-23 81.6 0.2 5e-23 81.2 0.2 1.2 1 0 0 1 1 1 1 Acylphosphatase IL1 PF00340.17 001285544.1_09022001_1 - 1.4e-35 121.5 0.7 2.2e-35 120.8 0.7 1.3 1 0 0 1 1 1 1 Interleukin-1 / 18 WWE PF02825.18 001285407.1_29525001_1 - 4.2e-16 59.1 2.5 9.2e-16 58.0 2.5 1.6 1 0 0 1 1 1 1 WWE domain zf-C3HC4_3 PF13920.4 001285407.1_29525001_1 - 8.4e-07 28.6 10.7 1.9e-06 27.5 10.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001285407.1_29525001_1 - 0.00011 22.3 12.6 0.00028 21.0 12.6 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.4 001285407.1_29525001_1 - 0.00016 21.5 9.3 0.00046 20.0 9.3 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001285407.1_29525001_1 - 0.00017 21.2 11.6 0.00043 20.0 11.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001285407.1_29525001_1 - 0.00074 19.2 12.0 0.0018 17.9 12.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.4 001285407.1_29525001_1 - 0.0087 15.8 10.2 0.018 14.7 10.2 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.4 001285407.1_29525001_1 - 0.033 14.0 11.4 0.065 13.1 11.4 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_10 PF16685.3 001285407.1_29525001_1 - 0.065 13.2 7.5 0.14 12.2 7.5 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_11 PF17123.3 001285407.1_29525001_1 - 2.2 8.0 10.8 7.4 6.3 10.8 2.0 1 0 0 1 1 1 0 RING-like zinc finger Insulin PF00049.16 001285697.1_09021001_1 - 3.1e-15 56.8 7.2 4.2e-13 50.0 4.8 2.6 2 1 0 2 2 2 1 Insulin/IGF/Relaxin family Ldh_1_N PF00056.21 001195775.1_49823001_3 - 3.2e-47 160.0 0.7 4.5e-47 159.5 0.7 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 001195775.1_49823001_3 - 5.6e-27 94.6 0.0 1.3e-26 93.3 0.0 1.6 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.14 001195775.1_49823001_3 - 0.011 15.1 1.5 0.075 12.5 0.1 2.3 1 1 0 2 2 2 0 Family 4 glycosyl hydrolase Glyco_hydro_47 PF01532.18 001195721.1_37929001_1 - 5.2e-147 490.3 0.0 6.2e-147 490.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Ribosomal_L6 PF00347.21 001284817.1_29524001_3 - 8.1e-32 109.6 1.4 7.8e-15 55.2 0.3 2.2 2 0 0 2 2 2 2 Ribosomal protein L6 Myelin_PLP PF01275.17 201592.2_26227001_2 - 1.5e-90 303.1 24.2 1.5e-90 303.1 24.2 1.6 2 0 0 2 2 2 1 Myelin proteolipid protein (PLP or lipophilin) Tissue_fac PF01108.15 001172904.1_09924001_2 - 4.9e-26 90.5 0.5 2.4e-25 88.3 0.2 2.1 2 0 0 2 2 2 1 Tissue factor Interfer-bind PF09294.8 001172904.1_09924001_2 - 1.7e-24 86.0 0.2 2.6e-23 82.2 0.0 2.2 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III ECSCR PF15820.3 001172904.1_09924001_2 - 0.0013 18.4 0.4 0.0024 17.5 0.4 1.3 1 0 0 1 1 1 1 Endothelial cell-specific chemotaxis regulator TMEM154 PF15102.4 001172904.1_09924001_2 - 0.01 15.6 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family DUF3377 PF11857.6 001172904.1_09924001_2 - 1.5 8.6 4.7 0.2 11.5 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) TIMP PF00965.15 001195690.1_37922001_1 - 1.1e-66 224.0 10.0 1.2e-66 223.9 10.0 1.0 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.19 001195690.1_37922001_1 - 0.0079 15.9 0.1 0.014 15.1 0.1 1.4 1 0 0 1 1 1 1 UNC-6/NTR/C345C module Proteasome PF00227.24 001285070.1_29523001_1 - 6.5e-52 175.7 0.0 1.2e-51 174.7 0.0 1.4 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.7 001285070.1_29523001_1 - 4.6e-13 48.4 0.0 8.4e-13 47.6 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature CFTR_R PF14396.4 001278757.1_09929001_2 - 1.8e-98 328.1 4.0 3.3e-98 327.3 4.0 1.4 1 0 0 1 1 1 1 Cystic fibrosis TM conductance regulator (CFTR), regulator domain ABC_membrane PF00664.21 001278757.1_09929001_2 - 3.3e-93 312.1 44.4 2.2e-50 171.7 21.1 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 001278757.1_09929001_2 - 3.2e-59 199.2 0.1 3.2e-33 115.0 0.0 3.0 3 0 0 3 3 2 2 ABC transporter SMC_N PF02463.17 001278757.1_09929001_2 - 4e-08 32.8 0.0 0.018 14.4 0.0 3.5 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.4 001278757.1_09929001_2 - 2.2e-07 30.9 2.0 0.043 13.5 0.0 3.7 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 001278757.1_09929001_2 - 2.2e-06 27.2 0.7 0.00072 19.1 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain T2SSE PF00437.18 001278757.1_09929001_2 - 6.8e-06 25.2 0.0 0.13 11.2 0.0 2.6 2 0 0 2 2 2 2 Type II/IV secretion system protein DUF258 PF03193.14 001278757.1_09929001_2 - 1.5e-05 24.8 1.0 0.015 15.1 0.1 2.7 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.4 001278757.1_09929001_2 - 2.8e-05 24.4 0.0 0.1 12.8 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.15 001278757.1_09929001_2 - 0.00041 20.3 3.9 0.063 13.2 0.1 2.9 3 0 0 3 3 2 2 Domain of unknown function DUF87 Zeta_toxin PF06414.10 001278757.1_09929001_2 - 0.00043 19.5 0.4 0.097 11.8 0.1 2.5 2 0 0 2 2 2 1 Zeta toxin AAA_22 PF13401.4 001278757.1_09929001_2 - 0.00088 19.4 0.4 2.8 8.1 0.0 3.3 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.21 001278757.1_09929001_2 - 0.0009 19.2 0.4 0.33 10.9 0.1 3.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase NACHT PF05729.10 001278757.1_09929001_2 - 0.0016 18.2 0.5 2.3 8.0 0.0 2.9 2 0 0 2 2 2 2 NACHT domain ArgK PF03308.14 001278757.1_09929001_2 - 0.0041 16.0 0.7 0.021 13.7 0.1 2.2 2 0 0 2 2 2 1 ArgK protein NTPase_1 PF03266.13 001278757.1_09929001_2 - 0.012 15.4 0.2 0.71 9.6 0.0 2.9 3 0 0 3 3 3 0 NTPase MobB PF03205.12 001278757.1_09929001_2 - 0.02 14.7 1.5 7.3 6.4 0.1 3.3 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.4 001278757.1_09929001_2 - 0.023 14.3 0.0 1.3 8.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain Roc PF08477.11 001278757.1_09929001_2 - 0.026 14.6 0.1 4.8 7.3 0.0 3.5 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase TsaE PF02367.15 001278757.1_09929001_2 - 0.027 14.4 0.4 9.5 6.1 0.1 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE cobW PF02492.17 001278757.1_09929001_2 - 0.042 13.3 2.0 2.9 7.3 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_19 PF13245.4 001278757.1_09929001_2 - 0.05 13.8 0.1 18 5.5 0.0 3.1 2 1 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.16 001278757.1_09929001_2 - 0.051 12.8 0.6 4.5 6.4 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_23 PF13476.4 001278757.1_09929001_2 - 0.098 13.0 16.0 0.88 9.9 0.1 4.3 4 0 0 4 4 4 0 AAA domain TrwB_AAD_bind PF10412.7 001278757.1_09929001_2 - 0.13 11.0 1.2 5.2 5.7 0.1 2.9 2 1 1 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain Dynamin_N PF00350.21 001278757.1_09929001_2 - 0.51 10.2 2.1 14 5.6 0.1 3.0 2 1 0 2 2 2 0 Dynamin family V-set PF07686.15 001257244.1_08022001_1 - 2e-11 43.9 0.0 2.6e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 001257244.1_08022001_1 - 1.8e-05 24.7 0.0 0.00021 21.3 0.0 2.1 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001257244.1_08022001_1 - 4.2e-05 23.4 0.0 0.00015 21.7 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001257244.1_08022001_1 - 5.9e-05 23.5 0.0 0.00034 21.0 0.0 2.0 1 1 0 1 1 1 1 Immunoglobulin domain Longin PF13774.4 001257244.1_08022001_1 - 0.065 13.1 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Regulated-SNARE-like domain ITI_HC_C PF06668.10 001281662.1_31327001_1 - 3.2e-71 238.8 0.0 5.9e-71 237.9 0.0 1.5 1 0 0 1 1 1 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus VIT PF08487.8 001281662.1_31327001_1 - 1.5e-31 108.8 0.4 2.8e-31 107.9 0.4 1.5 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA PF00092.26 001281662.1_31327001_1 - 3.2e-22 79.5 2.2 5.4e-22 78.7 2.2 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.4 001281662.1_31327001_1 - 1.1e-18 67.5 0.0 1.9e-18 66.7 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.4 001281662.1_31327001_1 - 4.6e-12 46.4 0.2 1.6e-11 44.7 0.2 1.9 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.12 001281662.1_31327001_1 - 0.00019 20.8 0.0 0.00042 19.6 0.0 1.5 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein SH3_8 PF13457.4 001281662.1_31327001_1 - 0.037 14.5 0.1 0.46 11.0 0.1 2.5 2 0 0 2 2 2 0 SH3-like domain DUF2201 PF09967.7 001281662.1_31327001_1 - 0.047 13.7 0.5 0.19 11.7 0.0 2.2 2 0 0 2 2 2 0 VWA-like domain (DUF2201) SWIB PF02201.16 001281662.1_31327001_1 - 0.12 12.1 0.0 0.29 10.9 0.0 1.6 1 0 0 1 1 1 0 SWIB/MDM2 domain OLF PF02191.14 001278850.1_22425001_3 - 1.2e-82 277.1 0.1 1.6e-82 276.7 0.1 1.1 1 0 0 1 1 1 1 Olfactomedin-like domain IncA PF04156.12 001278850.1_22425001_3 - 0.00053 19.7 15.4 0.00053 19.7 15.4 2.2 1 1 0 2 2 2 1 IncA protein APG6 PF04111.10 001278850.1_22425001_3 - 0.0019 17.5 8.6 0.0029 16.9 8.6 1.2 1 0 0 1 1 1 1 Autophagy protein Apg6 BRE1 PF08647.9 001278850.1_22425001_3 - 0.0088 16.0 3.7 0.0088 16.0 3.7 2.2 2 0 0 2 2 2 1 BRE1 E3 ubiquitin ligase NYD-SP28_assoc PF14775.4 001278850.1_22425001_3 - 0.098 12.6 10.1 0.064 13.2 2.4 2.6 1 1 1 2 2 2 0 Sperm tail C-terminal domain bZIP_1 PF00170.19 001278850.1_22425001_3 - 0.12 12.3 9.9 1.1 9.2 1.4 3.0 2 1 1 3 3 2 0 bZIP transcription factor ADIP PF11559.6 001278850.1_22425001_3 - 0.12 12.3 13.7 0.037 14.0 7.5 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding HALZ PF02183.16 001278850.1_22425001_3 - 0.13 12.3 10.6 0.22 11.6 8.2 2.5 1 1 1 2 2 2 0 Homeobox associated leucine zipper Leu_zip PF15294.4 001278850.1_22425001_3 - 0.36 10.2 7.6 0.68 9.3 7.6 1.5 1 1 0 1 1 1 0 Leucine zipper ZapB PF06005.10 001278850.1_22425001_3 - 0.46 10.8 20.8 0.13 12.6 6.2 3.3 2 1 1 3 3 3 0 Cell division protein ZapB KASH_CCD PF14662.4 001278850.1_22425001_3 - 0.49 10.1 11.0 0.064 13.0 5.5 2.0 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH DivIC PF04977.13 001278850.1_22425001_3 - 0.52 10.0 18.2 1 9.1 5.0 3.3 1 1 2 3 3 3 0 Septum formation initiator Spectrin PF00435.19 001278850.1_22425001_3 - 0.53 10.7 7.1 0.23 11.8 4.2 1.8 1 1 1 2 2 2 0 Spectrin repeat ATG16 PF08614.9 001278850.1_22425001_3 - 0.83 9.7 21.3 1.1 9.2 20.3 1.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Spc7 PF08317.9 001278850.1_22425001_3 - 1.1 8.0 11.1 0.25 10.1 6.9 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF972 PF06156.11 001278850.1_22425001_3 - 1.1 9.8 5.9 1 9.9 3.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF972) YlqD PF11068.6 001278850.1_22425001_3 - 1.2 9.3 6.8 1.6 9.0 2.8 2.2 2 0 0 2 2 2 0 YlqD protein V_ATPase_I PF01496.17 001278850.1_22425001_3 - 1.3 6.7 3.3 1.7 6.3 3.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3450 PF11932.6 001278850.1_22425001_3 - 1.7 7.7 13.5 0.19 10.8 7.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Cep57_MT_bd PF06657.11 001278850.1_22425001_3 - 1.8 8.9 9.0 0.41 11.0 4.9 1.9 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Exonuc_VII_L PF02601.13 001278850.1_22425001_3 - 2 7.7 6.7 3.1 7.1 6.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit TPR_MLP1_2 PF07926.10 001278850.1_22425001_3 - 4.3 7.3 16.5 18 5.3 16.5 1.9 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein TBPIP PF07106.11 001278850.1_22425001_3 - 4.9 6.8 8.4 3 7.4 4.2 2.1 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) MbeD_MobD PF04899.10 001278850.1_22425001_3 - 5.1 7.2 14.4 11 6.1 6.8 2.4 2 0 0 2 2 2 0 MbeD/MobD like DUF4407 PF14362.4 001278850.1_22425001_3 - 5.8 6.0 9.2 9.1 5.4 9.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) p450 PF00067.20 001281365.1_31324001_2 - 2.3e-148 494.7 0.2 2.6e-148 494.5 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 Med25_VWA PF11265.6 001281365.1_31324001_2 - 0.059 13.1 0.0 0.097 12.3 0.0 1.2 1 0 0 1 1 1 0 Mediator complex subunit 25 von Willebrand factor type A GST_C_3 PF14497.4 001172839.1_09922001_1 - 6.4e-19 67.9 0.1 1e-18 67.2 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.18 001172839.1_09922001_1 - 6.5e-18 64.7 0.0 1.2e-17 63.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 001172839.1_09922001_1 - 9.3e-15 54.5 0.1 1.7e-14 53.7 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 001172839.1_09922001_1 - 0.00056 20.1 0.0 0.001 19.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain NusG PF02357.17 001172839.1_09922001_1 - 0.00079 19.8 0.0 0.0017 18.7 0.0 1.5 1 0 0 1 1 1 1 Transcription termination factor nusG OAD_gamma PF04277.11 001287321.1_29523001_1 - 0.26 11.8 6.9 0.39 11.2 6.9 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain SUI1 PF01253.20 001287321.1_29523001_3 - 2.9e-28 98.1 1.0 6.2e-28 97.0 1.0 1.6 1 0 0 1 1 1 1 Translation initiation factor SUI1 EF1_GNE PF00736.17 001284982.1_29525001_3 - 4.1e-36 122.9 0.4 9e-36 121.8 0.4 1.6 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.7 001284982.1_29525001_3 - 2e-12 47.1 7.6 2e-12 47.1 7.6 3.3 3 0 0 3 3 3 1 Eukaryotic elongation factor 1 beta central acidic region Striatin PF08232.10 001284982.1_29525001_3 - 0.0085 16.6 2.3 0.0085 16.6 2.3 2.4 2 0 0 2 2 2 1 Striatin family TolA_bind_tri PF16331.3 001284982.1_29525001_3 - 0.017 15.1 0.1 0.051 13.5 0.1 1.8 1 0 0 1 1 1 0 TolA binding protein trimerisation JIP_LZII PF16471.3 001284982.1_29525001_3 - 0.026 14.6 0.9 0.07 13.2 0.9 1.7 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II KASH_CCD PF14662.4 001284982.1_29525001_3 - 0.051 13.3 1.1 0.16 11.7 0.1 2.1 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH Trimer_CC PF08954.9 001284982.1_29525001_3 - 0.066 12.7 2.5 0.14 11.6 0.0 2.7 3 0 0 3 3 3 0 Trimerisation motif RTC PF01137.19 001283155.1_29524001_2 - 4.9e-88 293.9 0.2 6e-88 293.6 0.2 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.11 001283155.1_29524001_2 - 7.1e-25 87.4 0.1 1.2e-24 86.7 0.1 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain Skp1 PF01466.17 001284756.1_29522001_1 - 2.1e-30 104.4 1.9 3.4e-30 103.8 1.9 1.3 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.13 001284756.1_29522001_1 - 5.9e-30 103.1 0.4 1.3e-29 102.0 0.2 1.7 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain Xlink PF00193.15 001281873.1_31326001_1 - 4.3e-18 65.4 0.0 4.3e-18 65.4 0.0 1.9 3 0 0 3 3 3 1 Extracellular link domain LYRIC PF15686.3 001281873.1_31326001_1 - 0.13 11.7 0.1 0.27 10.6 0.0 1.5 2 0 0 2 2 2 0 Lysine-rich CEACAM1 co-isolated protein family Hormone_2 PF00123.18 001172952.1_09923001_2 - 1.5e-40 136.7 3.0 5.1e-13 48.6 0.5 3.4 3 0 0 3 3 3 3 Peptide hormone Lipoprotein_10 PF03202.11 001172952.1_09923001_2 - 0.00066 20.0 2.9 0.46 10.8 0.1 3.1 2 1 1 3 3 3 2 Putative mycoplasma lipoprotein, C-terminal region V-set PF07686.15 001257242.1_08022001_1 - 2.9e-11 43.3 0.0 3.9e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 001257242.1_08022001_1 - 2.9e-05 24.0 0.0 0.00031 20.7 0.0 2.1 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001257242.1_08022001_1 - 6.7e-05 22.7 0.0 0.00022 21.1 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001257242.1_08022001_1 - 9.8e-05 22.8 0.0 0.0005 20.5 0.0 1.9 1 1 0 1 1 1 1 Immunoglobulin domain Longin PF13774.4 001257242.1_08022001_1 - 0.078 12.9 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Regulated-SNARE-like domain MRF_C2 PF13888.4 001033333.3_32927001_1 - 7.6e-50 168.2 0.5 7.6e-50 168.2 0.5 1.8 2 0 0 2 2 2 1 Myelin gene regulatory factor C-terminal domain 2 NDT80_PhoG PF05224.10 001033333.3_32927001_1 - 3.2e-27 95.8 1.1 5.4e-26 91.8 1.1 2.4 1 1 0 1 1 1 1 NDT80 / PhoG like DNA-binding family MRF_C1 PF13887.4 001033333.3_32927001_1 - 1.8e-21 74.8 0.7 3.4e-21 74.0 0.7 1.5 1 0 0 1 1 1 1 Myelin gene regulatory factor -C-terminal domain 1 Peptidase_S74 PF13884.4 001033333.3_32927001_1 - 1.2e-15 57.4 0.1 2.4e-15 56.5 0.1 1.5 1 0 0 1 1 1 1 Chaperone of endosialidase LMBR1 PF04791.14 001033333.3_32927001_1 - 0.11 11.2 0.2 0.16 10.7 0.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein p450 PF00067.20 001287574.1_09024001_1 - 3.8e-125 418.1 1.1 4.3e-125 417.9 1.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Rad60-SLD PF11976.6 001283462.1_29523001_1 - 7.3e-25 86.5 0.1 1.1e-24 85.9 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.21 001283462.1_29523001_1 - 6.3e-11 41.7 0.1 9.6e-11 41.1 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family IL12 PF03039.12 001285638.1_09022001_1 - 1.6e-112 374.0 6.6 1.8e-112 373.9 6.6 1.0 1 0 0 1 1 1 1 Interleukin-12 alpha subunit p450 PF00067.20 001281600.1_31324001_2 - 1.8e-132 442.3 0.4 2.1e-132 442.1 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 VEGF_C PF14554.4 001281843.1_31322001_1 - 5.3e-29 100.0 21.3 5.3e-29 100.0 21.3 2.2 3 0 0 3 3 3 1 VEGF heparin-binding domain PDGF PF00341.15 001281843.1_31322001_1 - 1.1e-26 92.8 6.3 1.1e-26 92.8 6.3 2.4 2 1 0 2 2 2 1 PDGF/VEGF domain CXCXC PF03128.12 001281843.1_31322001_1 - 2.8 8.4 19.8 0.81 10.1 0.8 3.8 3 0 0 3 3 3 0 CXCXC repeat Keratin_matx PF04579.10 001285774.1_09022001_1 - 7.7e-48 160.7 24.9 1.1e-47 160.1 24.9 1.3 1 0 0 1 1 1 1 Keratin, high-sulphur matrix protein Nop PF01798.16 001287661.1_29525001_3 - 2.9e-84 282.0 0.2 2.9e-84 282.0 0.2 2.3 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.11 001287661.1_29525001_3 - 2.6e-23 82.0 2.2 2.6e-23 82.0 2.2 2.5 2 0 0 2 2 2 1 NOP5NT (NUC127) domain CDC45 PF02724.12 001287661.1_29525001_3 - 0.22 9.6 15.8 0.35 9.0 15.8 1.3 1 0 0 1 1 1 0 CDC45-like protein p450 PF00067.20 001281931.1_31324001_3 - 4.4e-133 444.3 0.0 6.1e-133 443.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF2012 PF09430.8 001284831.1_29523001_2 - 1.9e-33 115.0 0.0 2.9e-33 114.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) CarboxypepD_reg PF13620.4 001284831.1_29523001_2 - 0.034 14.3 0.0 0.061 13.5 0.0 1.4 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain Annexin PF00191.18 001285067.1_29524001_1 - 1.9e-99 325.6 5.0 2.4e-26 91.5 0.4 4.1 4 0 0 4 4 4 4 Annexin p25-alpha PF05517.10 001285278.1_29522001_1 - 1.6e-68 229.6 8.8 1.6e-68 229.6 8.8 2.2 2 0 0 2 2 2 1 p25-alpha Presenilin PF01080.15 001285278.1_29522001_1 - 0.081 11.5 5.4 0.087 11.4 5.4 1.1 1 0 0 1 1 1 0 Presenilin RNA_pol_Rpc4 PF05132.12 001285278.1_29522001_2 - 0.0027 18.0 10.9 0.0036 17.6 10.9 1.3 1 0 0 1 1 1 1 RNA polymerase III RPC4 EOS1 PF12326.6 001285278.1_29522001_2 - 0.12 12.1 4.2 0.12 12.1 4.2 1.3 1 0 0 1 1 1 0 N-glycosylation protein 7tm_1 PF00001.19 001285278.1_29522001_2 - 1.4 8.0 6.7 1.6 7.8 6.7 1.4 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) TPR_1 PF00515.26 001172998.1_09925001_3 - 2.5e-25 87.1 2.8 2.9e-06 26.7 0.0 5.8 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.15 001172998.1_09925001_3 - 1e-21 75.1 6.5 0.00027 20.7 0.8 6.7 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.4 001172998.1_09925001_3 - 7.1e-20 70.3 0.4 2.2e-05 23.9 0.2 6.1 3 1 3 6 6 6 3 TPR repeat TPR_8 PF13181.4 001172998.1_09925001_3 - 3.7e-19 67.1 0.2 0.00089 19.2 0.1 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.4 001172998.1_09925001_3 - 5.8e-18 63.8 0.6 0.0019 18.3 0.1 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.4 001172998.1_09925001_3 - 2.3e-13 50.4 11.5 1.1e-05 25.9 0.4 5.1 3 2 3 6 6 5 4 Tetratricopeptide repeat TPR_19 PF14559.4 001172998.1_09925001_3 - 1.8e-12 47.5 2.8 0.0007 19.9 1.3 4.0 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.4 001172998.1_09925001_3 - 1.5e-11 44.3 4.6 1.3e-05 25.3 2.3 4.1 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.4 001172998.1_09925001_3 - 2e-11 43.6 24.1 0.0066 17.1 0.2 7.8 8 1 2 10 10 6 4 Tetratricopeptide repeat TPR_7 PF13176.4 001172998.1_09925001_3 - 9.4e-11 40.8 0.1 0.02 14.7 0.0 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.4 001172998.1_09925001_3 - 1.3e-07 31.5 5.9 0.011 15.7 1.2 3.7 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.4 001172998.1_09925001_3 - 9.6e-07 28.9 5.4 1.8 9.2 0.1 6.7 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_20 PF14561.4 001172998.1_09925001_3 - 1.4e-06 28.4 0.5 0.059 13.6 0.0 4.2 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.4 001172998.1_09925001_3 - 2.8e-06 26.9 4.1 0.011 15.4 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.5 001172998.1_09925001_3 - 1.6e-05 24.9 3.5 0.014 15.5 0.2 2.8 3 0 0 3 3 2 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF1641 PF07849.9 001172998.1_09925001_3 - 0.077 12.7 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) SHNi-TPR PF10516.7 001172998.1_09925001_3 - 0.24 10.8 4.2 34 3.9 0.0 4.2 4 0 0 4 4 4 0 SHNi-TPR Cpn60_TCP1 PF00118.22 001244180.1_49825001_3 - 7.8e-170 565.6 6.7 9.6e-170 565.3 6.7 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF1308 PF07000.9 001244180.1_49825001_3 - 0.046 12.7 0.1 0.073 12.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1308) Transferrin PF00405.15 001285548.1_09025001_3 - 6.6e-259 856.9 9.0 4.2e-175 581.5 0.0 2.0 2 0 0 2 2 2 2 Transferrin Phosphonate-bd PF12974.5 001285548.1_09025001_3 - 1.8e-11 44.0 0.0 0.00013 21.5 0.0 2.7 2 2 0 2 2 2 2 ABC transporter, phosphonate, periplasmic substrate-binding protein Cyclin PF08613.9 001287626.1_29524001_2 - 4.1e-12 46.6 0.4 4.1e-12 46.6 0.4 2.5 3 1 0 3 3 3 1 Cyclin Cyclin_N PF00134.21 001287626.1_29524001_2 - 1.2e-10 41.1 0.5 1.2e-10 41.1 0.5 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain RNA_polI_A34 PF08208.9 001287626.1_29524001_3 - 0.3 11.0 31.4 0.43 10.5 31.4 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 SCAN PF02023.15 001135614.2_39723001_3 - 6.4e-43 144.4 0.8 1.4e-42 143.2 0.8 1.6 1 0 0 1 1 1 1 SCAN domain zf-H2C2_2 PF13465.4 001135614.2_39723001_3 - 5.3e-25 86.6 19.3 1.3e-08 34.7 0.3 6.0 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2 PF00096.24 001135614.2_39723001_3 - 9e-24 82.4 18.3 1.4e-06 28.3 1.9 4.6 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001135614.2_39723001_3 - 6e-13 48.3 18.6 0.002 18.7 1.4 4.7 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001135614.2_39723001_3 - 3.3e-06 27.1 6.1 1.1 9.5 0.0 4.4 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001135614.2_39723001_3 - 5e-06 26.2 17.8 0.01 15.6 1.0 4.5 4 0 0 4 4 4 2 C2H2-type zinc finger DZR PF12773.5 001135614.2_39723001_3 - 1.4e-05 24.9 5.3 0.033 14.1 0.4 2.6 2 0 0 2 2 2 2 Double zinc ribbon Zn-ribbon_8 PF09723.8 001135614.2_39723001_3 - 1.6e-05 24.8 8.7 0.018 15.0 1.3 2.8 2 0 0 2 2 2 2 Zinc ribbon domain zf-LYAR PF08790.9 001135614.2_39723001_3 - 2.4e-05 24.0 6.3 3 7.7 0.0 4.4 4 0 0 4 4 4 3 LYAR-type C2HC zinc finger XPA_N PF01286.16 001135614.2_39723001_3 - 5e-05 23.1 8.1 2.2 8.2 0.1 4.4 4 0 0 4 4 4 3 XPA protein N-terminal zf-C2H2_11 PF16622.3 001135614.2_39723001_3 - 0.0028 17.2 16.0 0.75 9.5 0.1 4.4 4 0 0 4 4 4 2 zinc-finger C2H2-type C1_4 PF07975.10 001135614.2_39723001_3 - 0.017 15.2 8.4 0.7 10.1 1.1 3.2 1 1 2 3 3 3 0 TFIIH C1-like domain zf-BED PF02892.13 001135614.2_39723001_3 - 0.031 14.2 15.8 2 8.4 1.6 4.4 1 1 3 4 4 4 0 BED zinc finger YhfH PF14149.4 001135614.2_39723001_3 - 0.15 11.9 12.2 19 5.2 0.4 4.4 4 0 0 4 4 4 0 YhfH-like protein PHF5 PF03660.12 001135614.2_39723001_3 - 0.45 10.6 5.1 0.89 9.6 0.4 2.3 1 1 1 2 2 2 0 PHF5-like protein C1_1 PF00130.20 001135614.2_39723001_3 - 0.45 10.3 9.8 7.3 6.4 1.0 3.4 1 1 3 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) SprT-like PF10263.7 001135614.2_39723001_3 - 0.66 9.7 14.6 12 5.6 0.9 3.0 1 1 0 2 2 2 0 SprT-like family zinc_ribbon_15 PF17032.3 001135614.2_39723001_3 - 0.77 10.4 9.0 2 9.1 1.2 2.9 1 1 3 4 4 4 0 zinc-ribbon family zf-C2H2_7 PF15269.4 001135614.2_39723001_3 - 0.8 9.7 4.7 11 6.0 0.4 2.8 1 1 1 2 2 2 0 Zinc-finger LIM PF00412.20 001135614.2_39723001_3 - 1.6 8.9 7.1 66 3.7 3.9 3.3 2 1 1 3 3 3 0 LIM domain TFIIS_C PF01096.16 001135614.2_39723001_3 - 2.2 8.0 12.6 15 5.4 0.1 4.2 4 0 0 4 4 4 0 Transcription factor S-II (TFIIS) DUF3268 PF11672.6 001135614.2_39723001_3 - 3.4 7.9 6.1 6.1 7.1 0.4 2.4 1 1 0 2 2 2 0 zinc-finger-containing domain CpXC PF14353.4 001135614.2_39723001_3 - 4.7 7.1 6.0 84 3.1 0.1 3.8 1 1 1 3 3 3 0 CpXC protein ADK_lid PF05191.12 001135614.2_39723001_3 - 5.7 6.9 15.5 1.3 9.0 0.0 3.9 4 0 0 4 4 3 0 Adenylate kinase, active site lid zf-trcl PF13451.4 001135614.2_39723001_3 - 9.6 6.1 9.8 84 3.0 0.1 4.1 4 0 0 4 4 4 0 Probable zinc-ribbon domain Calc_CGRP_IAPP PF00214.17 001281574.1_31322001_2 - 1.2e-15 57.8 1.1 6.6e-15 55.4 0.5 1.9 1 1 1 2 2 2 2 Calcitonin / CGRP / IAPP family IL2 PF00715.15 001287567.1_09021001_1 - 2.1e-70 235.2 4.4 2.3e-70 235.0 4.4 1.0 1 0 0 1 1 1 1 Interleukin 2 GST_N PF02798.18 001287655.1_29522001_1 - 7.4e-23 80.6 0.0 1.5e-22 79.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.23 001287655.1_29522001_1 - 1.3e-16 60.5 0.0 2.1e-16 59.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.4 001287655.1_29522001_1 - 7.3e-16 58.1 0.0 1.4e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.2 001287655.1_29522001_1 - 2.3e-05 24.0 0.1 9e-05 22.1 0.1 2.0 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.4 001287655.1_29522001_1 - 0.00018 21.2 0.0 0.00053 19.7 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.4 001287655.1_29522001_1 - 0.0016 18.6 0.0 0.0034 17.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.4 001287655.1_29522001_1 - 0.021 15.0 0.0 0.041 14.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Bromo_TP PF07524.11 001287655.1_29522001_1 - 0.19 11.6 0.0 0.38 10.7 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated Neur_chan_LBD PF02931.21 001287622.1_29524001_3 - 1.1e-50 172.0 0.0 1.4e-50 171.6 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.14 001287622.1_29524001_3 - 2.5e-39 135.6 2.4 7.3e-31 107.9 5.1 2.2 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Sugar_tr PF00083.22 001287697.1_29524001_2 - 1.3e-31 109.8 13.6 1.8e-31 109.4 13.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.14 001287697.1_29524001_2 - 1.2e-26 93.4 22.6 1.9e-26 92.7 22.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily VIT1 PF01988.17 001287697.1_29524001_2 - 2.6 7.7 6.0 0.25 11.0 0.3 2.1 2 0 0 2 2 2 0 VIT family Septin PF00735.16 001009103.2_39725001_3 - 4.8e-123 409.7 0.1 4.8e-123 409.7 0.1 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.21 001009103.2_39725001_3 - 1.4e-06 28.2 0.1 4.2e-06 26.7 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.14 001009103.2_39725001_3 - 8.8e-06 25.6 8.2 0.00026 20.8 0.0 3.3 3 0 0 3 3 3 2 Protein of unknown function, DUF258 AIG1 PF04548.14 001009103.2_39725001_3 - 0.0035 16.6 0.0 0.0035 16.6 0.0 2.1 2 0 0 2 2 1 1 AIG1 family AAA_22 PF13401.4 001009103.2_39725001_3 - 0.021 15.0 0.0 0.064 13.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain Ras PF00071.20 001009103.2_39725001_3 - 0.022 14.2 0.0 0.056 12.9 0.0 1.7 1 0 0 1 1 1 0 Ras family AAA_16 PF13191.4 001009103.2_39725001_3 - 0.024 14.9 0.0 0.064 13.5 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain Exonuc_VII_L PF02601.13 001009103.2_39725001_3 - 0.027 13.9 9.2 0.04 13.4 9.2 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit AAA_29 PF13555.4 001009103.2_39725001_3 - 0.066 12.8 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.25 001009103.2_39725001_3 - 0.071 12.5 8.5 1.7 8.0 0.1 3.8 3 1 0 3 3 3 0 Elongation factor Tu GTP binding domain FeoB_N PF02421.16 001009103.2_39725001_3 - 0.077 12.4 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B ABC_tran PF00005.25 001009103.2_39725001_3 - 0.077 13.4 0.0 0.077 13.4 0.0 2.3 2 0 0 2 2 2 0 ABC transporter Gtr1_RagA PF04670.10 001009103.2_39725001_3 - 0.15 11.2 7.9 0.17 11.1 0.0 2.5 3 0 0 3 3 3 0 Gtr1/RagA G protein conserved region DUF87 PF01935.15 001009103.2_39725001_3 - 8 6.3 9.2 71 3.2 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function DUF87 p450 PF00067.20 001281373.1_31324001_2 - 1.7e-100 336.8 0.0 2.2e-100 336.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sec8_exocyst PF04048.12 001281373.1_31324001_2 - 0.03 14.1 0.7 0.06 13.1 0.7 1.4 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain Integrin_beta PF00362.16 001285538.1_09026001_2 - 2.1e-116 387.8 0.0 3e-116 387.3 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.9 001285538.1_09026001_2 - 4.9e-16 58.0 0.6 8.2e-16 57.3 0.6 1.4 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.10 001285538.1_09026001_2 - 2.5e-15 56.6 1.5 2.5e-15 56.6 1.5 4.0 4 1 1 5 5 5 1 Integrin beta tail domain PSI_integrin PF17205.1 001285538.1_09026001_2 - 9.1e-15 54.1 8.9 9.1e-15 54.1 8.9 4.6 5 0 0 5 5 5 1 Integrin plexin domain EGF_2 PF07974.11 001285538.1_09026001_2 - 1.4e-06 28.4 91.7 0.00022 21.4 11.5 6.6 5 2 1 6 6 6 4 EGF-like domain Lys PF00062.18 001285635.1_09022001_3 - 1.1e-54 183.8 7.9 1.9e-54 183.0 7.9 1.3 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family 7tm_1 PF00001.19 001172994.1_09923001_3 - 9.9e-40 136.3 23.7 3.7e-39 134.4 23.7 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001172994.1_09923001_3 - 0.03 13.9 18.0 0.16 11.6 18.0 1.9 1 1 0 1 1 1 0 Olfactory receptor DUF2346 PF09803.7 001172994.1_09923001_3 - 8.3 6.9 5.9 0.72 10.3 1.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2346) G-alpha PF00503.18 001172955.1_09923001_1 - 2.3e-123 411.7 2.0 2.7e-123 411.5 2.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 001172955.1_09923001_1 - 6.4e-18 64.7 0.4 8.3e-13 48.0 0.1 2.8 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001172955.1_09923001_1 - 2.9e-05 23.4 2.6 0.0047 16.2 0.7 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.11 001172955.1_09923001_1 - 0.00024 21.2 0.8 0.59 10.2 0.1 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.4 001172955.1_09923001_1 - 0.11 12.1 0.1 0.23 11.1 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain TniB PF05621.9 001172955.1_09923001_1 - 0.11 11.6 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein AAA_16 PF13191.4 001172955.1_09923001_1 - 0.11 12.7 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain FtsK_SpoIIIE PF01580.16 001172955.1_09923001_1 - 0.14 11.4 0.0 0.23 10.6 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family IL12p40_C PF10420.7 001281689.1_31325001_2 - 4.2e-20 71.9 4.5 8.3e-20 71.0 1.2 2.6 2 0 0 2 2 2 1 Cytokine interleukin-12p40 C-terminus Ig_5 PF16681.3 001281689.1_31325001_2 - 3.7e-07 30.3 1.1 1.1e-06 28.9 0.2 2.2 1 1 1 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_3 PF13927.4 001281689.1_31325001_2 - 6.9e-06 26.4 3.2 0.0003 21.2 0.2 2.7 2 0 0 2 2 2 1 Immunoglobulin domain Ig_4 PF16680.3 001281689.1_31325001_2 - 5.2e-05 23.4 0.2 0.00021 21.4 0.2 2.1 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 delta chain Ig_2 PF13895.4 001281689.1_31325001_2 - 0.00082 19.5 0.7 0.0096 16.1 0.1 2.7 1 1 1 2 2 2 1 Immunoglobulin domain fn3 PF00041.19 001281689.1_31325001_2 - 0.00082 19.5 0.2 0.0039 17.4 0.1 2.2 2 0 0 2 2 2 1 Fibronectin type III domain IL2 PF00715.15 001171099.1_37921001_1 - 1.4e-55 187.1 10.1 7.5e-39 132.8 1.0 2.0 1 1 1 2 2 2 2 Interleukin 2 Prot_inhib_II PF02428.13 001171099.1_37921001_3 - 0.012 16.0 2.1 0.021 15.1 2.1 1.4 1 0 0 1 1 1 0 Potato type II proteinase inhibitor family RSB_motif PF16294.3 001242605.1_32925001_3 - 4.6e-26 91.1 24.9 4.6e-26 91.1 24.9 5.2 3 2 2 5 5 5 1 RNSP1-SAP18 binding (RSB) motif RRM_1 PF00076.20 001242605.1_32925001_3 - 0.029 14.1 0.0 0.06 13.0 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Glyco_hydro_2_C PF02836.15 001285691.1_09026001_3 - 6.7e-08 31.9 0.0 3.5e-07 29.5 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.16 001285691.1_09026001_3 - 0.0012 18.7 0.5 0.0046 16.8 0.5 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain zf-C2H2_4 PF13894.4 001287653.1_29527001_3 - 1.8e-07 31.3 35.1 0.012 16.2 2.5 6.6 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2 PF00096.24 001287653.1_29527001_3 - 4.9e-07 29.7 27.9 0.0017 18.6 2.3 5.9 6 0 0 6 6 6 3 Zinc finger, C2H2 type CpXC PF14353.4 001287653.1_29527001_3 - 4.9e-06 26.4 7.8 0.022 14.6 0.0 3.7 3 1 0 3 3 3 2 CpXC protein zf-C2H2_jaz PF12171.6 001287653.1_29527001_3 - 0.0011 19.0 10.7 0.022 15.0 1.3 4.4 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-FCS PF06467.12 001287653.1_29527001_3 - 0.011 15.6 1.1 0.56 10.1 0.1 3.0 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zf-BED PF02892.13 001287653.1_29527001_3 - 0.017 15.0 27.7 3.3 7.7 3.3 5.7 4 2 1 5 5 5 0 BED zinc finger zf-C2HE PF16278.3 001287653.1_29527001_3 - 0.026 14.9 21.4 0.55 10.6 4.1 5.0 4 2 0 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_aberr PF17017.3 001287653.1_29527001_3 - 0.067 13.2 16.6 2.8 7.9 0.3 3.9 3 1 1 4 4 4 0 Aberrant zinc-finger zf-C2H2_2 PF12756.5 001287653.1_29527001_3 - 0.069 13.3 21.0 0.47 10.7 0.8 4.8 2 2 1 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.5 001287653.1_29527001_3 - 1.6 9.1 12.3 1.9 8.9 0.3 4.7 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zinc_ribbon_2 PF13240.4 001287653.1_29527001_3 - 2.3 7.9 8.2 15 5.3 0.4 3.4 3 0 0 3 3 3 0 zinc-ribbon domain DUF302 PF03625.12 001279603.1_24224001_1 - 0.17 11.6 0.0 0.31 10.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF302 ICAM_N PF03921.12 001279603.1_24224001_2 - 3e-38 129.3 0.5 2.9e-37 126.1 0.1 2.4 2 0 0 2 2 2 1 Intercellular adhesion molecule (ICAM), N-terminal domain Ig_2 PF13895.4 001279603.1_24224001_2 - 2.1e-16 59.9 1.6 0.0041 17.3 0.1 5.3 5 0 0 5 5 5 4 Immunoglobulin domain Ig_3 PF13927.4 001279603.1_24224001_2 - 1.5e-05 25.3 6.3 2.6 8.6 0.0 5.2 5 1 0 5 5 5 3 Immunoglobulin domain ig PF00047.23 001279603.1_24224001_2 - 1.7e-05 24.8 7.6 0.81 9.8 0.1 6.4 6 2 0 6 6 6 2 Immunoglobulin domain I-set PF07679.14 001279603.1_24224001_2 - 0.0057 16.6 0.2 2.4 8.2 0.2 4.3 4 1 0 4 4 4 1 Immunoglobulin I-set domain C2-set_2 PF08205.10 001279603.1_24224001_2 - 0.0063 16.4 3.9 1.5 8.8 0.0 4.1 4 2 0 5 5 5 2 CD80-like C2-set immunoglobulin domain Adhes-Ig_like PF09085.8 001279603.1_24224001_2 - 0.015 15.3 0.6 0.39 10.7 0.1 3.3 3 1 1 4 4 4 0 Adhesion molecule, immunoglobulin-like Toxin_30 PF08117.9 001279603.1_24224001_3 - 3.2 8.0 7.7 12 6.1 7.7 2.1 1 0 0 1 1 1 0 Ptu family ERbeta_N PF12497.6 001265821.2_29625001_1 - 9.2e-51 170.3 7.0 1.6e-50 169.5 7.0 1.4 1 0 0 1 1 1 1 Estrogen receptor beta Hormone_recep PF00104.28 001265821.2_29625001_1 - 1.3e-36 126.0 2.1 1.8e-36 125.5 2.1 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001265821.2_29625001_1 - 4.5e-31 107.0 14.9 1.2e-30 105.6 13.1 2.5 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) 7tm_1 PF00001.19 001267759.1_08023001_2 - 5.4e-43 147.0 0.7 6.8e-43 146.7 0.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF758 PF05527.9 001171296.1_37922001_1 - 2.9e-73 245.6 0.0 3.2e-73 245.4 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF758) MoaE PF02391.15 001171296.1_37922001_1 - 0.12 12.4 0.1 0.21 11.7 0.1 1.4 1 0 0 1 1 1 0 MoaE protein DAO PF01266.22 001281680.1_31325001_3 - 7.3e-48 163.8 0.1 1.3e-47 163.0 0.0 1.4 2 0 0 2 2 2 1 FAD dependent oxidoreductase DAO_C PF16901.3 001281680.1_31325001_3 - 8.9e-41 138.6 0.0 1.9e-40 137.5 0.0 1.6 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase EF-hand_7 PF13499.4 001281680.1_31325001_3 - 1.1e-09 38.5 0.5 2.3e-09 37.5 0.5 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 001281680.1_31325001_3 - 1.4e-08 33.5 0.2 0.00014 21.1 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.4 001281680.1_31325001_3 - 8.4e-07 28.3 0.1 0.084 12.7 0.1 3.0 2 0 0 2 2 2 2 EF-hand domain FAD_binding_2 PF00890.22 001281680.1_31325001_3 - 1.5e-06 27.4 0.4 0.00012 21.2 0.1 2.1 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.5 001281680.1_31325001_3 - 6.1e-06 25.7 0.3 2.9e-05 23.5 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.20 001281680.1_31325001_3 - 3.2e-05 23.0 0.1 0.0042 16.1 0.1 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A EF-hand_8 PF13833.4 001281680.1_31325001_3 - 5.1e-05 22.8 0.4 0.00018 21.0 0.1 2.1 1 1 1 2 2 2 1 EF-hand domain pair Pyr_redox_2 PF07992.12 001281680.1_31325001_3 - 0.0011 18.1 0.1 0.0034 16.5 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase EF-hand_5 PF13202.4 001281680.1_31325001_3 - 0.0016 17.7 0.5 0.58 9.6 0.0 2.6 2 0 0 2 2 2 1 EF hand EF-hand_9 PF14658.4 001281680.1_31325001_3 - 0.012 15.8 0.0 0.039 14.1 0.0 1.9 2 0 0 2 2 1 0 EF-hand domain NAD_binding_8 PF13450.4 001281680.1_31325001_3 - 0.018 15.1 0.3 0.087 12.9 0.2 2.2 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.12 001281680.1_31325001_3 - 0.026 13.1 0.1 0.04 12.5 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein EF-hand_4 PF12763.5 001281680.1_31325001_3 - 0.044 13.6 0.2 0.098 12.5 0.2 1.5 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Thi4 PF01946.15 001281680.1_31325001_3 - 0.078 12.1 0.0 0.18 10.9 0.0 1.6 1 0 0 1 1 1 0 Thi4 family FAD_binding_3 PF01494.17 001281680.1_31325001_3 - 0.14 11.3 0.0 1.3 8.1 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain KH_1 PF00013.27 001287296.1_29525001_3 - 2.8e-46 155.0 7.0 1.8e-16 59.5 0.8 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.15 001287296.1_29525001_3 - 6.9e-08 32.1 17.1 0.0004 20.0 3.5 3.3 2 1 0 3 3 3 3 KH domain KH_4 PF13083.4 001287296.1_29525001_3 - 7.7e-08 32.0 5.7 0.015 15.1 0.0 3.6 4 0 0 4 4 4 3 KH domain KH_5 PF13184.4 001287296.1_29525001_3 - 0.11 12.5 4.1 4.4 7.3 0.2 3.3 3 0 0 3 3 3 0 NusA-like KH domain Proteasome PF00227.24 001283242.1_29523001_3 - 1.2e-54 184.5 0.0 1.6e-54 184.1 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.7 001283242.1_29523001_3 - 1.1e-13 50.4 0.1 1.9e-13 49.6 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature zf-RING_UBOX PF13445.4 001279549.1_24223001_1 - 4.9e-12 45.5 5.8 5.4e-12 45.4 3.5 2.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.4 001279549.1_24223001_1 - 1e-10 41.4 8.7 1e-10 41.4 8.7 2.0 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING SPRY PF00622.26 001279549.1_24223001_1 - 4.7e-10 39.5 0.1 1e-09 38.4 0.1 1.5 1 0 0 1 1 1 1 SPRY domain zf-C3HC4 PF00097.23 001279549.1_24223001_1 - 3.4e-09 36.3 8.0 9.5e-09 34.9 8.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001279549.1_24223001_1 - 6.3e-08 32.5 4.2 6.3e-08 32.5 4.2 3.1 3 1 0 3 3 2 2 B-box zinc finger zf-C3HC4_2 PF13923.4 001279549.1_24223001_1 - 6.4e-08 32.2 8.9 2e-07 30.6 8.9 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001279549.1_24223001_1 - 1e-07 32.0 7.5 1e-07 32.0 7.5 2.0 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.4 001279549.1_24223001_1 - 4.7e-07 29.4 5.3 4.7e-07 29.4 5.3 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001279549.1_24223001_1 - 1e-06 28.4 6.5 1e-06 28.4 6.5 2.2 2 0 0 2 2 2 1 zinc-RING finger domain TMF_TATA_bd PF12325.6 001279549.1_24223001_1 - 2.2e-06 27.7 1.8 2.2e-06 27.7 1.8 2.3 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding U-box PF04564.13 001279549.1_24223001_1 - 0.0029 17.6 0.0 0.0067 16.5 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-RING_10 PF16685.3 001279549.1_24223001_1 - 0.014 15.4 5.5 0.014 15.4 5.5 2.1 1 1 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_4 PF14570.4 001279549.1_24223001_1 - 0.036 13.7 5.9 0.33 10.6 6.2 2.5 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.4 001279549.1_24223001_1 - 0.071 12.9 3.5 0.22 11.3 3.5 1.9 1 1 0 1 1 1 0 zf-RING of BARD1-type protein zf-Nse PF11789.6 001279549.1_24223001_1 - 0.088 12.5 3.9 0.28 10.9 3.9 1.9 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit AAA_11 PF13086.4 001279549.1_24223001_1 - 0.2 11.2 5.3 0.29 10.7 5.3 1.2 1 0 0 1 1 1 0 AAA domain Prok-RING_4 PF14447.4 001279549.1_24223001_1 - 0.59 9.9 16.4 0.33 10.7 11.4 2.9 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 IncA PF04156.12 001279549.1_24223001_1 - 1.6 8.3 14.8 2.7 7.6 14.8 1.3 1 0 0 1 1 1 0 IncA protein CENP-Q PF13094.4 001279549.1_24223001_1 - 7.8 6.5 14.7 13 5.8 14.7 1.3 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit TNF PF00229.16 001285277.1_29522001_2 - 4.3e-40 136.5 0.0 6e-40 136.0 0.0 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family Ribonuc_L-PSP PF01042.19 001285713.1_09023001_1 - 4.7e-42 142.7 0.3 5.8e-42 142.4 0.3 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP Corona_6B_7B PF03262.11 001285713.1_09023001_1 - 0.056 12.7 0.0 0.083 12.2 0.0 1.1 1 0 0 1 1 1 0 Coronavirus 6B/7B protein zf-3CxxC PF13695.4 001283967.1_29526001_1 - 2.8e-21 75.7 2.3 5.2e-21 74.8 2.3 1.5 1 0 0 1 1 1 1 Zinc-binding domain Pkinase_Tyr PF07714.15 001281381.1_31329001_3 - 1.1e-85 286.9 0.0 1.6e-85 286.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.22 001281381.1_31329001_3 - 6.8e-55 183.9 0.0 1.9e-30 105.1 0.0 2.3 2 0 0 2 2 2 2 Receptor L domain GF_recep_IV PF14843.4 001281381.1_31329001_3 - 8.9e-45 151.6 73.0 5.1e-41 139.4 28.7 4.4 2 1 1 3 3 3 2 Growth factor receptor domain IV Pkinase PF00069.23 001281381.1_31329001_3 - 3e-36 125.0 0.0 4.2e-36 124.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.18 001281381.1_31329001_3 - 5.3e-26 91.1 77.3 3.1e-24 85.4 30.5 4.0 2 1 1 3 3 3 2 Furin-like cysteine rich region APH PF01636.21 001281381.1_31329001_3 - 0.021 14.6 0.2 0.041 13.7 0.2 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family 7tm_1 PF00001.19 001284639.1_29525001_1 - 1.4e-30 106.3 23.1 2.3e-30 105.6 23.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GnHR_trans PF12369.6 001284639.1_29525001_1 - 8.1e-27 93.7 0.2 1.5e-26 92.8 0.2 1.5 1 0 0 1 1 1 1 Gonadotropin hormone receptor transmembrane region LRR_8 PF13855.4 001284639.1_29525001_1 - 1.9e-21 75.4 13.9 4.9e-06 26.1 0.0 5.4 3 2 2 5 5 5 5 Leucine rich repeat LRR_5 PF13306.4 001284639.1_29525001_1 - 1.5e-13 50.7 0.8 1.4e-06 28.1 0.0 2.4 1 1 0 2 2 2 2 Leucine rich repeats (6 copies) LRRNT PF01462.16 001284639.1_29525001_1 - 1.8e-08 33.7 3.1 1.8e-08 33.7 3.1 2.5 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_4 PF12799.5 001284639.1_29525001_1 - 2.9e-05 24.2 20.8 0.74 10.2 0.1 5.1 3 2 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001284639.1_29525001_1 - 0.00084 18.7 1.6 0.00084 18.7 1.6 2.5 1 1 0 2 2 2 1 Leucine-rich repeat zf-H2C2_2 PF13465.4 001283159.1_29525001_1 - 3.7e-54 178.7 57.4 8.5e-09 35.3 0.4 9.2 9 0 0 9 9 9 8 Zinc-finger double domain zf-C2H2 PF00096.24 001283159.1_29525001_1 - 1.2e-37 126.1 58.9 2.9e-06 27.3 0.3 9.0 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001283159.1_29525001_1 - 1e-23 81.8 52.6 0.006 17.2 1.2 8.8 8 0 0 8 8 8 8 C2H2-type zinc finger KRAB PF01352.25 001283159.1_29525001_1 - 1.4e-23 82.1 0.9 2.4e-23 81.4 0.9 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 001283159.1_29525001_1 - 4.6e-08 32.7 38.5 0.081 12.8 3.0 8.5 8 0 0 8 8 8 4 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001283159.1_29525001_1 - 9.8e-07 28.7 33.2 0.32 11.0 2.9 6.4 2 1 5 7 7 7 7 Zinc ribbon domain DZR PF12773.5 001283159.1_29525001_1 - 3.5e-05 23.6 24.3 0.14 12.0 4.8 4.6 3 1 1 4 4 4 3 Double zinc ribbon zf-C2H2_jaz PF12171.6 001283159.1_29525001_1 - 0.00033 20.7 38.8 0.33 11.2 0.0 8.0 8 0 0 8 8 8 3 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.3 001283159.1_29525001_1 - 0.0014 19.2 27.0 0.25 12.0 0.9 4.7 1 1 5 6 6 6 4 zinc-ribbon family XPA_N PF01286.16 001283159.1_29525001_1 - 0.0014 18.5 27.9 2.9 7.9 0.4 8.2 8 0 0 8 8 8 1 XPA protein N-terminal CpXC PF14353.4 001283159.1_29525001_1 - 0.0042 17.0 22.2 6.6 6.7 0.2 6.6 3 3 1 5 5 5 2 CpXC protein zf-C2H2_8 PF15909.3 001283159.1_29525001_1 - 0.0069 16.5 25.2 0.32 11.2 4.4 4.6 1 1 4 5 5 5 2 C2H2-type zinc ribbon zf-LYAR PF08790.9 001283159.1_29525001_1 - 0.046 13.5 32.3 2.3 8.1 1.0 8.2 8 0 0 8 8 8 0 LYAR-type C2HC zinc finger C1_4 PF07975.10 001283159.1_29525001_1 - 0.13 12.4 34.1 0.29 11.3 1.4 5.8 1 1 5 7 7 7 0 TFIIH C1-like domain zf-C2H2_11 PF16622.3 001283159.1_29525001_1 - 0.33 10.6 29.6 4.1 7.1 0.0 7.6 8 0 0 8 8 8 0 zinc-finger C2H2-type GATA PF00320.25 001283159.1_29525001_1 - 0.38 10.3 23.1 11 5.6 0.5 6.3 5 1 0 5 5 5 0 GATA zinc finger HypA PF01155.17 001283159.1_29525001_1 - 0.41 10.5 23.8 1.6 8.6 0.8 4.4 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-trcl PF13451.4 001283159.1_29525001_1 - 0.59 9.9 33.6 1.4 8.8 0.1 7.7 6 2 0 6 6 6 0 Probable zinc-ribbon domain Zn_Tnp_IS1595 PF12760.5 001283159.1_29525001_1 - 4.9 7.1 36.5 4.9 7.1 5.9 5.3 2 1 2 4 4 4 0 Transposase zinc-ribbon domain zf-C2HE PF16278.3 001283159.1_29525001_1 - 7.4 7.0 41.6 37 4.7 3.1 8.2 2 2 2 4 4 3 0 C2HE / C2H2 / C2HC zinc-binding finger RNA_POL_M_15KD PF02150.14 001283159.1_29525001_1 - 8.6 6.2 18.4 5.4 6.9 0.2 5.8 6 0 0 6 6 6 0 RNA polymerases M/15 Kd subunit COX5A PF02284.14 001279709.1_24221001_1 - 9.3e-46 153.9 0.0 1.2e-45 153.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va GHBP PF12772.5 001172706.1_09925001_2 - 3.8e-104 348.3 5.2 5e-104 347.9 5.2 1.1 1 0 0 1 1 1 1 Growth hormone receptor binding EpoR_lig-bind PF09067.8 001172706.1_09925001_2 - 5.9e-10 39.2 3.7 5.9e-10 39.2 3.7 1.9 2 0 0 2 2 2 1 Erythropoietin receptor, ligand binding fn3 PF00041.19 001172706.1_09925001_2 - 2.8e-05 24.2 0.2 6e-05 23.2 0.2 1.6 1 0 0 1 1 1 1 Fibronectin type III domain Sarcoglycan_1 PF04790.11 001281391.1_31322001_1 - 1.1e-78 264.1 0.0 1.3e-78 263.9 0.0 1.0 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein DUF2345 PF10106.7 001281391.1_31322001_1 - 0.0026 17.5 0.0 0.057 13.2 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2345) Methyltransf_32 PF13679.4 001284791.1_29525001_3 - 1.3e-09 38.1 6.3 1.7e-08 34.5 5.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.4 001284791.1_29525001_3 - 1.4e-08 34.5 0.0 8.1e-08 32.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain GidB PF02527.13 001284791.1_29525001_3 - 1e-05 24.8 0.0 1.9e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G TRM13 PF05206.12 001284791.1_29525001_3 - 0.00045 19.7 6.2 0.13 11.6 1.1 2.9 2 1 1 3 3 3 2 Methyltransferase TRM13 GST_C_3 PF14497.4 001284791.1_29525001_3 - 0.00069 19.6 0.1 0.0021 18.1 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain MTS PF05175.12 001284791.1_29525001_3 - 0.00069 19.1 0.0 0.0013 18.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.4 001284791.1_29525001_3 - 0.0019 18.7 0.0 0.0045 17.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain GST_C_2 PF13410.4 001284791.1_29525001_3 - 0.0029 17.4 0.1 0.0096 15.7 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Ubie_methyltran PF01209.16 001284791.1_29525001_3 - 0.0063 15.7 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.15 001284791.1_29525001_3 - 0.0095 15.3 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_16 PF10294.7 001284791.1_29525001_3 - 0.017 14.7 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase GST_C PF00043.23 001284791.1_29525001_3 - 0.12 12.5 0.0 0.31 11.1 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Histone PF00125.22 001171112.1_37922001_1 - 9.3e-54 181.2 1.7 1.1e-53 181.0 1.7 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.4 001171112.1_37922001_1 - 0.00024 21.0 0.0 0.00045 20.2 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.4 001171112.1_37922001_1 - 0.0013 19.0 0.0 0.002 18.3 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.3 001171112.1_37922001_1 - 0.02 15.3 1.4 0.035 14.6 1.4 1.3 1 0 0 1 1 1 0 PCNA-associated factor SAM_decarbox PF01536.14 001281650.1_31323001_2 - 7e-125 416.6 0.2 8.2e-125 416.3 0.2 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase Lectin_C PF00059.19 001253746.1_32925001_2 - 5.1e-25 88.2 0.7 5.1e-25 88.2 0.7 2.2 2 0 0 2 2 2 1 Lectin C-type domain HemX PF04375.12 001253746.1_32925001_2 - 0.01 15.0 7.0 0.018 14.2 7.0 1.3 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Ly49 PF08391.8 001253746.1_32925001_2 - 0.014 15.6 3.3 0.026 14.7 3.3 1.5 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region AIP3 PF03915.11 001253746.1_32925001_2 - 0.033 13.2 3.6 0.046 12.7 3.6 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 IncA PF04156.12 001253746.1_32925001_2 - 0.036 13.7 9.3 0.086 12.5 9.3 1.5 1 0 0 1 1 1 0 IncA protein DUF3584 PF12128.6 001253746.1_32925001_2 - 0.094 10.1 7.1 0.13 9.6 7.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) UL45 PF05473.10 001253746.1_32925001_2 - 0.1 12.1 0.1 0.17 11.4 0.1 1.3 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like ATG16 PF08614.9 001253746.1_32925001_2 - 0.11 12.5 10.1 0.17 11.9 10.1 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) ADIP PF11559.6 001253746.1_32925001_2 - 0.16 12.0 13.2 0.23 11.4 13.2 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Golgin_A5 PF09787.7 001253746.1_32925001_2 - 0.46 9.8 7.8 0.72 9.1 7.8 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 Exonuc_VII_L PF02601.13 001253746.1_32925001_2 - 0.49 9.8 3.0 0.71 9.3 3.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2968 PF11180.6 001253746.1_32925001_2 - 1.1 8.8 9.4 1.7 8.2 9.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) DUF1664 PF07889.10 001253746.1_32925001_2 - 1.2 9.0 5.3 2 8.3 5.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) IFT57 PF10498.7 001253746.1_32925001_2 - 1.3 7.8 8.9 1.8 7.3 8.9 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Gp58 PF07902.9 001253746.1_32925001_2 - 1.9 6.7 5.7 2.7 6.2 5.7 1.1 1 0 0 1 1 1 0 gp58-like protein Laminin_II PF06009.10 001253746.1_32925001_2 - 2.7 7.9 10.1 4.4 7.2 10.1 1.2 1 0 0 1 1 1 0 Laminin Domain II Macoilin PF09726.7 001253746.1_32925001_2 - 3.8 5.8 8.9 5.8 5.2 8.9 1.2 1 0 0 1 1 1 0 Transmembrane protein 2Fe-2S_thioredx PF01257.17 001279641.1_24222001_1 - 1.7e-65 219.2 0.2 2e-65 218.9 0.2 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin p450 PF00067.20 001281686.1_31324001_2 - 2e-167 557.5 0.1 2.3e-167 557.3 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 SPC25 PF06703.9 001287288.1_29523001_3 - 1.5e-44 151.5 0.2 2e-44 151.1 0.2 1.2 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) RhlB PF12300.6 001287288.1_29523001_3 - 0.63 10.1 1.7 0.84 9.7 1.7 1.1 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB Ldh_1_C PF02866.16 001278853.1_22423001_1 - 1.1e-55 188.0 0.0 2.5e-55 186.8 0.0 1.6 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.21 001278853.1_22423001_1 - 9.2e-49 165.0 0.0 1.4e-48 164.5 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.22 001278853.1_22423001_1 - 0.00045 20.5 0.0 0.0049 17.2 0.0 2.2 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.17 001278853.1_22423001_1 - 0.0055 15.6 0.0 0.0076 15.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.4 001278853.1_22423001_1 - 0.011 15.5 0.0 0.045 13.5 0.0 1.9 2 0 0 2 2 2 0 NAD(P)H-binding THF_DHG_CYH_C PF02882.17 001278853.1_22423001_1 - 0.024 13.8 0.0 0.12 11.6 0.0 2.1 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DapB_N PF01113.18 001278853.1_22423001_1 - 0.099 12.6 0.0 0.28 11.2 0.0 1.8 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus zf-H2C2_2 PF13465.4 001289623.1_32929001_1 - 2.4e-42 141.4 39.7 1.1e-08 35.0 0.9 8.2 8 0 0 8 8 8 6 Zinc-finger double domain zf-C2H2 PF00096.24 001289623.1_32929001_1 - 3e-25 87.1 59.8 2.9e-05 24.1 0.7 8.3 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001289623.1_32929001_1 - 2e-19 68.4 57.5 0.006 17.2 3.7 8.9 8 0 0 8 8 7 7 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001289623.1_32929001_1 - 3.9e-10 39.3 31.8 0.048 13.5 0.1 7.7 7 0 0 7 7 7 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001289623.1_32929001_1 - 5.9e-07 29.5 17.5 1.3 9.3 0.1 6.5 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 001289623.1_32929001_1 - 0.00044 19.8 32.0 0.24 11.1 0.5 7.5 7 0 0 7 7 7 2 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.3 001289623.1_32929001_1 - 0.004 16.8 0.5 0.004 16.8 0.5 6.8 7 0 0 7 7 7 2 zinc-finger C2H2-type zf-C2H2_8 PF15909.3 001289623.1_32929001_1 - 0.025 14.7 16.6 0.54 10.5 6.6 3.4 1 1 2 3 3 3 0 C2H2-type zinc ribbon zinc_ribbon_15 PF17032.3 001289623.1_32929001_1 - 0.042 14.5 17.1 5.9 7.6 3.7 3.9 1 1 2 3 3 3 0 zinc-ribbon family DUF3268 PF11672.6 001289623.1_32929001_1 - 0.052 13.8 15.1 1.1 9.4 0.4 3.4 3 0 0 3 3 3 0 zinc-finger-containing domain zf-met PF12874.5 001289623.1_32929001_1 - 0.6 10.4 43.6 0.075 13.3 0.9 7.1 7 0 0 7 7 7 0 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.8 001289623.1_32929001_1 - 5 7.2 25.8 1.6 8.8 1.7 5.5 2 2 5 7 7 7 0 Zinc ribbon domain BTB PF00651.29 001289623.1_32929001_2 - 4.5e-05 23.5 0.0 7.8e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain P2X_receptor PF00864.17 001172709.1_09924001_1 - 2e-143 477.8 0.0 2.7e-143 477.4 0.0 1.1 1 0 0 1 1 1 1 ATP P2X receptor LRR_8 PF13855.4 001285603.1_09025001_1 - 7.7e-36 121.5 51.1 2.1e-13 49.7 6.1 8.2 6 3 2 8 8 8 7 Leucine rich repeat TIR PF01582.18 001285603.1_09025001_1 - 3.9e-23 82.0 0.6 7.1e-23 81.2 0.6 1.4 1 0 0 1 1 1 1 TIR domain LRR_4 PF12799.5 001285603.1_09025001_1 - 7.5e-21 73.7 51.6 8.8e-05 22.6 3.7 8.9 6 2 3 9 9 9 8 Leucine Rich repeats (2 copies) TIR_2 PF13676.4 001285603.1_09025001_1 - 2.2e-10 40.6 0.0 5.8e-10 39.3 0.0 1.7 1 0 0 1 1 1 1 TIR domain LRR_9 PF14580.4 001285603.1_09025001_1 - 1.2e-06 28.0 18.2 0.0012 18.2 0.6 4.5 2 2 3 5 5 5 3 Leucine-rich repeat LRR_5 PF13306.4 001285603.1_09025001_1 - 1.7e-06 27.9 0.3 1.7e-06 27.9 0.3 3.6 3 2 1 4 4 4 2 Leucine rich repeats (6 copies) LRRCT PF01463.22 001285603.1_09025001_1 - 0.012 16.0 1.2 0.039 14.4 0.3 2.5 2 0 0 2 2 2 0 Leucine rich repeat C-terminal domain LRR_6 PF13516.4 001285603.1_09025001_1 - 0.028 14.3 31.7 1.2 9.2 0.6 9.0 10 0 0 10 10 10 0 Leucine Rich repeat LRR_1 PF00560.31 001285603.1_09025001_1 - 2.7 8.7 49.6 0.1 13.0 1.0 11.2 13 2 0 13 13 13 0 Leucine Rich Repeat DUF3890 PF13029.4 001285603.1_09025001_1 - 2.8 8.3 11.6 11 6.5 0.4 4.5 4 0 0 4 4 4 0 Domain of unknown function (DUF3890) HELP PF03451.12 001286567.1_32929001_2 - 1.4e-30 104.8 0.1 2.4e-30 104.0 0.1 1.4 1 0 0 1 1 1 1 HELP motif WD40 PF00400.30 001286567.1_32929001_2 - 4.4e-27 93.6 21.5 0.00036 21.1 0.1 9.8 9 0 0 9 9 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001286567.1_32929001_2 - 8.9e-07 29.0 0.3 0.37 11.0 0.0 5.2 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain SlyX PF04102.10 001286567.1_32929001_2 - 0.11 13.0 0.3 0.2 12.1 0.3 1.4 1 0 0 1 1 1 0 SlyX Ribosomal_S7 PF00177.19 001286567.1_32929001_2 - 0.4 10.2 2.7 0.17 11.4 0.1 1.6 2 0 0 2 2 2 0 Ribosomal protein S7p/S5e TIMP PF00965.15 001082232.2_37922001_3 - 3.6e-60 202.7 1.3 4.3e-60 202.5 1.3 1.0 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase IL4 PF00727.16 001285681.1_09022001_3 - 1.1e-44 151.0 4.0 1.4e-44 150.6 4.0 1.1 1 0 0 1 1 1 1 Interleukin 4 DUF4942 PF13708.4 001285681.1_09022001_3 - 0.086 12.7 0.0 0.1 12.4 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4942) Peptidase_M75 PF09375.8 001285681.1_09022001_3 - 0.25 10.7 0.0 0.3 10.4 0.0 1.0 1 0 0 1 1 1 0 Imelysin RCC1 PF00415.16 001283943.1_29524001_1 - 1.5e-34 118.2 16.3 8.3e-13 48.6 0.7 5.2 4 1 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.4 001283943.1_29524001_1 - 6.3e-22 76.7 20.3 5.2e-09 35.6 0.3 5.2 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat Hira PF07569.9 001283943.1_29524001_1 - 0.058 13.0 0.0 1.6 8.3 0.0 2.2 2 0 0 2 2 2 0 TUP1-like enhancer of split Longin PF13774.4 001283676.1_29524001_2 - 5e-19 68.0 0.2 9e-19 67.2 0.2 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain WD40 PF00400.30 001284943.1_29524001_2 - 0.0006 20.4 2.9 1.4 9.8 1.0 4.3 4 0 0 4 4 4 1 WD domain, G-beta repeat WD40_like PF17005.3 001284943.1_29524001_2 - 0.0013 18.0 0.0 0.24 10.5 0.0 2.3 2 0 0 2 2 2 2 WD40-like domain ANAPC4_WD40 PF12894.5 001284943.1_29524001_2 - 0.057 13.6 0.0 9.1 6.5 0.0 3.1 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain 7tm_1 PF00001.19 001281565.1_31325001_2 - 2.7e-31 108.7 19.8 4.3e-31 108.0 19.8 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GnHR_trans PF12369.6 001281565.1_31325001_2 - 2.9e-24 85.5 1.5 5.3e-24 84.7 1.5 1.5 1 0 0 1 1 1 1 Gonadotropin hormone receptor transmembrane region LRR_8 PF13855.4 001281565.1_31325001_2 - 3.4e-21 74.6 21.9 2.4e-07 30.2 0.3 5.2 1 1 5 6 6 6 5 Leucine rich repeat LRR_5 PF13306.4 001281565.1_31325001_2 - 5.8e-13 48.8 0.2 2.1e-06 27.6 0.0 2.3 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) LRRNT PF01462.16 001281565.1_31325001_2 - 2.5e-06 26.9 4.1 2.5e-06 26.9 4.1 2.8 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_4 PF12799.5 001281565.1_31325001_2 - 0.00017 21.7 21.3 3 8.3 4.7 5.4 3 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001281565.1_31325001_2 - 0.016 14.6 0.8 0.016 14.6 0.8 2.5 3 0 0 3 3 3 0 Leucine-rich repeat Sarcoglycan_1 PF04790.11 001281618.1_31323001_1 - 2.2e-78 263.1 0.0 2.9e-78 262.7 0.0 1.1 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein DUF2345 PF10106.7 001281618.1_31323001_1 - 0.0015 18.3 0.0 0.0033 17.2 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2345) TNF PF00229.16 001286442.1_09022001_1 - 2.3e-40 137.3 0.0 3.7e-40 136.7 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family IL8 PF00048.18 001172938.1_09923001_1 - 7.5e-12 45.1 0.1 1.5e-11 44.1 0.1 1.5 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like 3Beta_HSD PF01073.17 001283982.1_29526001_2 - 1.4e-67 227.5 0.0 1.8e-67 227.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.19 001283982.1_29526001_2 - 1.6e-29 103.0 0.0 2.1e-29 102.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.3 001283982.1_29526001_2 - 3.8e-12 46.1 0.0 1.3e-11 44.3 0.0 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.15 001283982.1_29526001_2 - 4.7e-11 42.2 0.0 6.4e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.13 001283982.1_29526001_2 - 4.9e-07 29.0 0.0 1.2e-06 27.8 0.0 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.4 001283982.1_29526001_2 - 1.3e-06 28.3 0.0 2.2e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.10 001283982.1_29526001_2 - 1.4e-06 27.5 0.0 2.3e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein adh_short PF00106.23 001283982.1_29526001_2 - 0.046 13.1 0.0 0.07 12.4 0.0 1.2 1 0 0 1 1 1 0 short chain dehydrogenase Filament PF00038.19 001285766.1_09024001_3 - 2e-98 329.7 16.9 2.6e-98 329.3 16.9 1.1 1 0 0 1 1 1 1 Intermediate filament protein Phage_Mu_Gam PF07352.10 001285766.1_09024001_3 - 0.0021 17.8 12.6 0.018 14.8 0.2 3.7 4 0 0 4 4 4 2 Bacteriophage Mu Gam like protein TPR_MLP1_2 PF07926.10 001285766.1_09024001_3 - 0.0078 16.1 1.5 0.0078 16.1 1.5 3.9 4 1 0 4 4 4 2 TPR/MLP1/MLP2-like protein FlxA PF14282.4 001285766.1_09024001_3 - 1.2 9.0 17.4 0.034 14.0 5.6 3.4 2 1 1 3 3 3 0 FlxA-like protein V_ATPase_I PF01496.17 001285766.1_09024001_3 - 1.8 6.2 7.2 0.93 7.2 4.6 1.7 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Reo_sigmaC PF04582.10 001285766.1_09024001_3 - 9.1 5.4 8.6 1.3 8.3 2.1 2.3 2 1 1 3 3 3 0 Reovirus sigma C capsid protein p450 PF00067.20 001284909.1_29524001_1 - 9.8e-122 406.9 0.3 1.1e-121 406.7 0.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.20 001285747.1_09027001_3 - 2.9e-99 332.8 0.6 4.2e-99 332.3 0.6 1.1 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_C2 PF00648.19 001285341.1_29526001_1 - 3.2e-129 430.1 0.0 6.5e-129 429.0 0.0 1.5 2 0 0 2 2 2 1 Calpain family cysteine protease Calpain_III PF01067.20 001285341.1_29526001_1 - 7.6e-53 178.5 0.0 2.3e-52 176.9 0.0 1.8 2 0 0 2 2 2 1 Calpain large subunit, domain III EF-hand_8 PF13833.4 001285341.1_29526001_1 - 3e-13 49.2 7.3 3.1e-10 39.5 0.1 4.0 4 1 0 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.4 001285341.1_29526001_1 - 8.4e-10 37.7 5.6 0.0057 16.4 0.0 4.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.30 001285341.1_29526001_1 - 8.5e-10 37.3 5.1 0.008 15.5 0.0 4.5 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.4 001285341.1_29526001_1 - 3.4e-08 33.7 3.6 0.039 14.3 0.1 3.9 4 1 0 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.4 001285341.1_29526001_1 - 0.42 10.1 7.9 3 7.4 0.0 4.1 4 0 0 4 4 4 0 EF hand Ribosomal_L21e PF01157.16 001285632.1_09022001_3 - 4.7e-52 173.8 8.3 4.7e-52 173.8 8.3 1.6 2 0 0 2 2 2 1 Ribosomal protein L21e CLP_protease PF00574.21 001285632.1_09022001_3 - 0.097 12.4 0.2 0.14 11.9 0.2 1.2 1 0 0 1 1 1 0 Clp protease Pkinase PF00069.23 001283662.1_29526001_1 - 5.1e-61 206.2 0.0 1.1e-60 205.1 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001283662.1_29526001_1 - 1.5e-45 155.4 0.0 2.9e-45 154.5 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 001283662.1_29526001_1 - 0.013 15.3 0.7 0.042 13.6 0.0 2.2 3 0 0 3 3 3 0 Phosphotransferase enzyme family Hormone_1 PF00103.18 001281615.1_31322001_3 - 5.8e-46 156.8 0.0 7.5e-46 156.5 0.0 1.1 1 0 0 1 1 1 1 Somatotropin hormone family GnRH PF00446.15 001195436.1_29621001_1 - 5.6e-05 23.0 3.2 5.6e-05 23.0 3.2 1.6 2 0 0 2 2 2 1 Gonadotropin-releasing hormone Pkinase_Tyr PF07714.15 001285724.1_09028001_1 - 7.2e-103 343.3 0.0 1e-102 342.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001285724.1_09028001_1 - 5.2e-43 147.2 0.0 1.9e-30 106.0 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.4 001285724.1_09028001_1 - 7.5e-23 80.8 8.7 9.2e-08 32.5 0.2 4.7 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.14 001285724.1_09028001_1 - 2.7e-15 56.1 7.5 5.9e-07 29.3 0.3 5.3 4 2 0 4 4 4 3 Immunoglobulin I-set domain ig PF00047.23 001285724.1_09028001_1 - 1.1e-14 54.2 10.6 1.6e-12 47.3 0.8 4.2 4 0 0 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.4 001285724.1_09028001_1 - 6.9e-12 45.4 11.1 0.0019 18.4 0.3 5.6 5 1 0 5 5 5 4 Immunoglobulin domain C1-set PF07654.13 001285724.1_09028001_1 - 0.0009 19.5 0.4 0.0009 19.5 0.4 2.6 3 0 0 3 3 2 1 Immunoglobulin C1-set domain V-set PF07686.15 001285724.1_09028001_1 - 0.02 14.9 11.1 0.29 11.2 0.1 5.4 5 3 1 6 6 6 0 Immunoglobulin V-set domain Ig_4 PF16680.3 001285724.1_09028001_1 - 0.022 15.0 0.9 7.2 6.9 0.0 3.5 2 1 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.10 001285724.1_09028001_1 - 0.12 12.4 3.0 8.6 6.4 0.0 3.6 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain APH PF01636.21 001285724.1_09028001_1 - 0.12 12.2 0.0 0.19 11.5 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Neuro_bHLH PF12533.6 001284857.1_29524001_1 - 1.5e-39 135.9 3.8 2.4e-39 135.3 3.8 1.3 1 0 0 1 1 1 1 Neuronal helix-loop-helix transcription factor HLH PF00010.24 001284857.1_29524001_1 - 1.4e-15 56.9 0.8 2.4e-15 56.1 0.8 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Ribosomal_L30_N PF08079.10 001284598.1_29522001_3 - 2.3e-30 104.5 15.1 6.3e-30 103.1 15.1 1.8 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.18 001284598.1_29522001_3 - 3.6e-26 90.7 2.8 7.7e-26 89.6 1.4 2.3 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e Complex1_51K PF01512.15 001279544.1_24223001_1 - 7e-50 168.7 0.0 1.2e-49 168.0 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.7 001279544.1_24223001_1 - 9e-31 105.7 0.2 2.9e-30 104.0 0.0 1.9 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.7 001279544.1_24223001_1 - 2.7e-07 30.2 0.0 5.3e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 SLBB domain GST_C_3 PF14497.4 001281846.1_31322001_1 - 4.8e-18 65.1 0.0 7.7e-18 64.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.23 001281846.1_31322001_1 - 1.8e-14 53.6 0.0 3.2e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.18 001281846.1_31322001_1 - 4.6e-07 30.0 0.0 8.2e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.4 001281846.1_31322001_1 - 0.0048 16.7 0.0 0.0099 15.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain IRK PF01007.18 001172754.1_09923001_1 - 4.6e-91 305.0 0.0 5.7e-91 304.7 0.0 1.0 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 001172754.1_09923001_1 - 7.9e-05 22.4 3.2 0.00016 21.4 3.2 1.6 1 1 0 1 1 1 1 Ion channel ADH_N_2 PF16884.3 001172980.1_09925001_1 - 5.6e-40 135.5 0.0 8.5e-40 134.9 0.0 1.3 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.24 001172980.1_09925001_1 - 1.1e-26 93.1 0.0 1.8e-26 92.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.4 001172980.1_09925001_1 - 5.3e-09 37.1 0.0 1.1e-08 36.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase p450 PF00067.20 001287570.1_09024001_2 - 2.5e-149 497.8 0.0 2.9e-149 497.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Acetyltransf_1 PF00583.23 001281591.1_31322001_1 - 3.9e-14 52.8 0.0 5.7e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.5 001281591.1_31322001_1 - 2.9e-06 27.5 0.0 5.9e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.5 001281591.1_31322001_1 - 0.00026 20.8 0.0 0.00048 19.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.8 001281591.1_31322001_1 - 0.13 12.1 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein CFTR_R PF14396.4 001242734.1_37629001_2 - 1.1e-103 345.2 0.9 1.1e-103 345.2 0.9 2.0 2 0 0 2 2 2 1 Cystic fibrosis TM conductance regulator (CFTR), regulator domain ABC_membrane PF00664.21 001242734.1_37629001_2 - 1.2e-95 320.1 43.0 2e-51 175.1 23.4 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 001242734.1_37629001_2 - 1.4e-56 190.7 0.0 1.5e-30 106.3 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 001242734.1_37629001_2 - 3.6e-07 29.7 0.0 0.002 17.5 0.0 3.0 2 2 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.4 001242734.1_37629001_2 - 1.4e-06 28.2 1.3 0.11 12.1 0.0 3.5 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system T2SSE PF00437.18 001242734.1_37629001_2 - 7.1e-06 25.1 0.0 0.015 14.2 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_29 PF13555.4 001242734.1_37629001_2 - 2.8e-05 23.6 2.2 0.0031 17.1 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF258 PF03193.14 001242734.1_37629001_2 - 5.5e-05 23.0 0.4 0.046 13.5 0.1 2.6 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.4 001242734.1_37629001_2 - 0.0015 18.8 0.0 1.5 9.1 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain NTPase_1 PF03266.13 001242734.1_37629001_2 - 0.0055 16.5 0.3 0.2 11.4 0.0 2.9 3 0 0 3 3 3 1 NTPase NACHT PF05729.10 001242734.1_37629001_2 - 0.0058 16.4 0.4 3.2 7.5 0.1 2.7 2 0 0 2 2 2 1 NACHT domain DUF87 PF01935.15 001242734.1_37629001_2 - 0.0074 16.2 5.7 0.25 11.2 0.1 3.2 2 1 0 2 2 2 1 Domain of unknown function DUF87 MMR_HSR1 PF01926.21 001242734.1_37629001_2 - 0.0074 16.2 0.3 1.8 8.6 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase Zeta_toxin PF06414.10 001242734.1_37629001_2 - 0.0075 15.5 0.3 0.33 10.1 0.1 2.5 2 0 0 2 2 2 1 Zeta toxin AAA_22 PF13401.4 001242734.1_37629001_2 - 0.013 15.7 0.2 9.5 6.4 0.1 3.1 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.4 001242734.1_37629001_2 - 0.013 15.9 10.1 3.4 8.0 0.1 3.7 3 0 0 3 3 3 0 AAA domain ArgK PF03308.14 001242734.1_37629001_2 - 0.018 13.9 0.4 0.12 11.2 0.0 2.3 3 0 0 3 3 3 0 ArgK protein TsaE PF02367.15 001242734.1_37629001_2 - 0.029 14.3 0.0 2.5 8.0 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE FtsK_SpoIIIE PF01580.16 001242734.1_37629001_2 - 0.047 12.9 0.3 10 5.3 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_30 PF13604.4 001242734.1_37629001_2 - 0.059 13.0 0.0 2.7 7.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.7 001242734.1_37629001_2 - 0.092 11.5 0.3 2.9 6.6 0.0 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain cobW PF02492.17 001242734.1_37629001_2 - 0.12 11.8 1.4 5.4 6.4 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.12 001242734.1_37629001_2 - 0.14 11.9 1.1 25 4.7 0.1 3.2 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.4 001242734.1_37629001_2 - 0.2 11.9 1.3 12 6.1 0.1 3.4 4 0 0 4 4 3 0 AAA domain Tubulin PF00091.23 001285253.1_29524001_1 - 7.3e-69 231.8 0.0 9.8e-69 231.4 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 001285253.1_29524001_1 - 2.4e-51 173.1 0.0 3.7e-51 172.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 001285253.1_29524001_1 - 0.0018 17.9 0.0 0.0034 17.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain p450 PF00067.20 001281640.1_31324001_1 - 3.9e-122 408.2 0.8 4.5e-122 408.0 0.8 1.0 1 0 0 1 1 1 1 Cytochrome P450 COX5A PF02284.14 001279515.1_40421001_1 - 3.3e-46 155.4 0.0 4.1e-46 155.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va Transthyretin PF00576.19 001283593.1_29521001_3 - 7.3e-20 71.6 0.0 9.3e-20 71.2 0.0 1.0 1 0 0 1 1 1 1 HIUase/Transthyretin family IL12p40_C PF10420.7 001285700.1_09022001_1 - 4.4e-22 78.2 4.7 5.4e-22 77.9 0.7 2.4 2 0 0 2 2 2 1 Cytokine interleukin-12p40 C-terminus Ig_5 PF16681.3 001285700.1_09022001_1 - 1.3e-06 28.6 2.2 1.4e-05 25.3 0.1 2.7 2 1 1 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_3 PF13927.4 001285700.1_09022001_1 - 8.2e-06 26.2 4.9 2.3e-05 24.8 0.2 3.0 3 0 0 3 3 3 1 Immunoglobulin domain fn3 PF00041.19 001285700.1_09022001_1 - 1.4e-05 25.2 0.3 0.00029 21.0 0.3 2.8 2 0 0 2 2 2 1 Fibronectin type III domain Ig_4 PF16680.3 001285700.1_09022001_1 - 1.8e-05 24.9 2.2 0.0003 21.0 0.0 2.9 2 1 1 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Ig_2 PF13895.4 001285700.1_09022001_1 - 8.6e-05 22.7 0.3 0.0025 18.0 0.0 2.8 1 1 1 2 2 2 1 Immunoglobulin domain I-set PF07679.14 001285700.1_09022001_1 - 0.066 13.1 4.2 0.24 11.4 0.2 3.7 4 2 0 4 4 4 0 Immunoglobulin I-set domain V-set PF07686.15 001285700.1_09022001_1 - 0.09 12.8 3.3 26 4.9 0.0 3.7 3 1 0 4 4 4 0 Immunoglobulin V-set domain FA_hydroxylase PF04116.11 001283683.1_29525001_1 - 4e-17 62.7 14.6 4e-17 62.7 14.6 1.8 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Cyt-b5 PF00173.26 001283683.1_29525001_1 - 4.5e-14 52.2 0.1 1e-13 51.1 0.0 1.7 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain COX14 PF14880.4 001283683.1_29525001_1 - 0.013 15.2 3.8 0.03 14.0 3.8 1.6 1 0 0 1 1 1 0 Cytochrome oxidase c assembly WD40 PF00400.30 001283895.1_29524001_1 - 4.9e-65 213.8 17.4 2.7e-09 37.4 0.0 8.3 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001283895.1_29524001_1 - 9.1e-21 73.8 0.6 0.00048 20.2 0.0 6.8 1 1 6 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.3 001283895.1_29524001_1 - 1.4e-10 40.9 1.8 0.26 10.4 0.0 5.5 1 1 2 5 5 5 5 WD40-like domain Nup160 PF11715.6 001283895.1_29524001_1 - 2.5e-05 23.0 5.1 1 7.7 0.0 5.7 2 1 5 7 7 7 3 Nucleoporin Nup120/160 CEP19 PF14933.4 001283895.1_29524001_1 - 0.00038 20.7 0.0 0.00054 20.2 0.0 1.2 1 0 0 1 1 1 1 CEP19-like protein Ge1_WD40 PF16529.3 001283895.1_29524001_1 - 0.001 18.0 4.0 0.4 9.5 0.4 3.4 1 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.4 001283895.1_29524001_1 - 0.016 15.6 0.5 0.92 10.0 0.0 3.6 4 0 0 4 4 4 0 PQQ-like domain Frtz PF11768.6 001283895.1_29524001_1 - 0.032 12.4 0.1 0.57 8.3 0.0 2.6 2 1 1 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz FOXP-CC PF16159.3 001279537.1_24225001_1 - 3.3e-35 120.4 4.2 3.3e-35 120.4 4.2 4.8 3 1 2 5 5 5 1 FOXP coiled-coil domain Forkhead PF00250.16 001279537.1_24225001_1 - 2.5e-28 98.1 0.2 1.1e-27 96.1 0.2 2.1 1 0 0 1 1 1 1 Forkhead domain Plasmodium_Vir PF05795.9 001279537.1_24225001_1 - 0.38 10.0 11.3 0.85 8.8 9.3 2.2 2 0 0 2 2 2 0 Plasmodium vivax Vir protein CobT PF06213.10 001279537.1_24225001_1 - 0.43 9.8 33.3 0.78 8.9 33.3 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RR_TM4-6 PF06459.10 001279537.1_24225001_1 - 0.68 9.6 24.6 1.6 8.4 24.6 1.7 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4746 PF15928.3 001279537.1_24225001_1 - 1.2 8.3 14.7 2.6 7.3 14.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF1764 PF08576.8 001279537.1_24225001_1 - 3.6 8.4 17.7 14 6.5 17.7 2.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) TT_ORF1 PF02956.12 001279537.1_24225001_1 - 6.2 5.2 25.5 10 4.5 25.5 1.2 1 0 0 1 1 1 0 TT viral orf 1 hDGE_amylase PF14701.4 001279537.1_24225001_1 - 6.3 5.6 22.2 14 4.5 22.2 1.5 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Apt1 PF10351.7 001279537.1_24225001_2 - 0.42 9.3 19.5 0.56 8.9 19.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF1510 PF07423.9 001279537.1_24225001_2 - 4.6 6.5 8.6 6.5 6.0 8.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Connexin PF00029.17 001198948.1_37924001_1 - 9.6e-93 310.0 3.7 1.3e-92 309.5 3.7 1.2 1 0 0 1 1 1 1 Connexin Connexin43 PF03508.11 001198948.1_37924001_1 - 7e-11 41.3 15.4 1.4e-10 40.4 15.4 1.5 1 0 0 1 1 1 1 Gap junction alpha-1 protein (Cx43) Connexin40_C PF16791.3 001198948.1_37924001_1 - 3.1e-05 25.1 2.0 4.9e-05 24.4 2.0 1.3 1 0 0 1 1 1 1 Connexin 40 C-terminal domain Ammonium_transp PF00909.19 001198948.1_37924001_1 - 0.15 10.6 0.1 0.23 10.0 0.1 1.2 1 0 0 1 1 1 0 Ammonium Transporter Family TEX29 PF15839.3 001198948.1_37924001_1 - 7.4 7.1 6.0 2.2 8.8 0.2 2.4 2 1 0 2 2 2 0 Testis-expressed sequence 29 protein Ribosomal_S19 PF00203.19 001281611.1_31321001_3 - 1.5e-40 136.8 0.4 2.4e-40 136.2 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein S19 Prok_Ub PF14454.4 001281611.1_31321001_3 - 0.021 14.3 0.1 0.055 13.0 0.1 1.6 1 0 0 1 1 1 0 Prokaryotic Ubiquitin MAP65_ASE1 PF03999.10 001281611.1_31321001_3 - 0.03 12.9 1.1 0.036 12.6 1.1 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) LCAT PF02450.13 001281611.1_31321001_3 - 0.12 11.4 0.1 0.15 11.0 0.1 1.1 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Xlink PF00193.15 001281874.1_31326001_1 - 3.9e-18 65.5 0.0 3.9e-18 65.5 0.0 2.0 3 0 0 3 3 3 1 Extracellular link domain LYRIC PF15686.3 001281874.1_31326001_1 - 0.2 11.0 1.9 0.3 10.5 0.3 1.8 1 1 1 2 2 2 0 Lysine-rich CEACAM1 co-isolated protein family Serpin PF00079.18 001281654.1_31323001_1 - 2.7e-113 378.9 0.7 3.1e-113 378.7 0.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF1266 PF06889.9 001281654.1_31323001_1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1266) CENP-T_N PF16171.3 001284848.1_29524001_1 - 1.3e-187 623.2 26.0 1.9e-187 622.7 26.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T N-terminus CENP-T_C PF15511.4 001284848.1_29524001_1 - 2.1e-35 120.9 0.1 3.6e-35 120.2 0.1 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.4 001284848.1_29524001_1 - 3.8e-09 36.7 0.0 6.6e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.21 001284848.1_29524001_1 - 0.0016 18.6 0.1 0.0035 17.5 0.1 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.11 001284848.1_29524001_1 - 0.0021 17.9 0.0 0.0036 17.1 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated Histone PF00125.22 001284848.1_29524001_1 - 0.0081 16.4 1.4 0.012 15.9 0.0 2.0 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.14 001284848.1_29524001_1 - 0.049 13.5 0.0 0.091 12.7 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit RabGAP-TBC PF00566.16 001319606.1_29525001_3 - 3.7e-52 177.0 2.5 5.3e-52 176.5 2.5 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF4502 PF14950.4 001319606.1_29525001_3 - 0.017 14.4 1.0 0.028 13.8 1.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4502) Jacalin PF01419.15 001309360.1_45723001_1 - 2.1e-16 59.9 0.0 3.3e-16 59.3 0.0 1.3 1 0 0 1 1 1 1 Jacalin-like lectin domain Trypsin PF00089.24 008504.3_32923001_2 - 1.3e-61 208.1 0.0 1.5e-61 207.9 0.0 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 008504.3_32923001_2 - 6.1e-08 33.5 0.0 9.7e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 008504.3_32923001_2 - 0.00013 22.2 0.0 0.0003 21.0 0.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Peptidase_S29 PF02907.13 008504.3_32923001_2 - 0.034 13.7 0.1 0.059 13.0 0.1 1.3 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease IL1 PF00340.17 001305893.1_29722001_1 - 3.4e-44 149.2 0.2 6.1e-44 148.4 0.2 1.4 1 0 0 1 1 1 1 Interleukin-1 / 18 IL1_propep PF02394.14 001305893.1_29722001_1 - 2.4e-42 144.1 0.2 9.5e-42 142.2 0.1 2.0 2 0 0 2 2 2 1 Interleukin-1 propeptide Inhibitor_I71 PF12628.5 001305893.1_29722001_1 - 0.044 13.5 0.1 0.064 13.0 0.1 1.2 1 0 0 1 1 1 0 Falstatin, cysteine peptidase inhibitor DUF4186 PF13811.4 001319387.1_29524001_1 - 0.1 12.5 0.8 0.21 11.5 0.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4186) RRM_1 PF00076.20 001319387.1_29524001_2 - 2.7e-43 145.5 0.1 1.2e-16 60.2 0.0 3.8 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001319387.1_29524001_2 - 2.9e-07 30.4 0.0 0.069 13.1 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif Nup35_RRM_2 PF14605.4 001319387.1_29524001_2 - 0.00083 19.1 0.0 0.15 11.9 0.0 3.5 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.4 001319387.1_29524001_2 - 0.0015 18.0 0.0 0.092 12.2 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOP5NT PF08156.11 001319387.1_29524001_2 - 0.082 13.1 0.3 52 4.1 0.0 3.3 3 0 0 3 3 3 0 NOP5NT (NUC127) domain PHM7_cyt PF14703.4 001319387.1_29524001_2 - 0.12 12.4 0.4 17 5.4 0.0 3.3 3 1 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter TF_Otx PF03529.11 001319387.1_29524001_2 - 1.1 9.6 14.3 0.41 10.9 3.6 2.5 2 0 0 2 2 2 0 Otx1 transcription factor LRR_8 PF13855.4 001319457.1_29526001_3 - 3.1e-60 199.7 62.7 3.5e-12 45.8 4.3 6.9 1 1 7 8 8 8 8 Leucine rich repeat LRR_5 PF13306.4 001319457.1_29526001_3 - 5e-24 84.6 0.0 1.7e-10 40.8 0.0 3.2 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_4 PF12799.5 001319457.1_29526001_3 - 9.6e-21 73.3 29.7 0.00023 21.3 2.7 6.9 6 0 0 6 6 6 5 Leucine Rich repeats (2 copies) I-set PF07679.14 001319457.1_29526001_3 - 4.2e-13 49.0 0.0 7.5e-13 48.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.4 001319457.1_29526001_3 - 1.2e-10 41.7 0.0 2.6e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.4 001319457.1_29526001_3 - 4.6e-07 30.0 0.0 8.7e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain LRR_9 PF14580.4 001319457.1_29526001_3 - 9.2e-07 28.4 12.1 0.0021 17.4 1.6 3.6 2 2 2 4 4 4 3 Leucine-rich repeat ig PF00047.23 001319457.1_29526001_3 - 1.6e-06 28.1 0.0 3.1e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.31 001319457.1_29526001_3 - 0.00068 19.6 28.8 22 5.9 0.1 11.0 11 1 1 12 12 12 0 Leucine Rich Repeat LRRNT PF01462.16 001319457.1_29526001_3 - 0.0079 15.7 3.4 0.0079 15.7 3.4 3.2 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain V-set PF07686.15 001319457.1_29526001_3 - 0.16 12.0 0.0 0.47 10.5 0.0 1.8 1 1 0 1 1 1 0 Immunoglobulin V-set domain LRR_6 PF13516.4 001319457.1_29526001_3 - 5.3 7.2 38.5 3.8 7.7 0.1 9.0 12 0 0 12 12 11 0 Leucine Rich repeat Phosphodiest PF01663.20 001285995.2_32927001_3 - 7.1e-77 259.3 0.0 1.1e-74 252.1 0.0 2.1 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Somatomedin_B PF01033.15 001285995.2_32927001_3 - 1.1e-14 54.3 38.0 3.9e-09 36.6 13.1 3.4 4 0 0 4 4 4 2 Somatomedin B domain Endonuclease_NS PF01223.21 001285995.2_32927001_3 - 7.7e-11 42.1 0.0 1.3e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Sulfatase PF00884.21 001285995.2_32927001_3 - 6.4e-05 22.4 0.0 0.026 13.8 0.0 2.2 2 0 0 2 2 2 2 Sulfatase IL8 PF00048.18 001305922.1_29721001_3 - 1.9e-17 63.0 0.3 4.5e-17 61.8 0.3 1.6 2 0 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like LPAM_1 PF08139.10 001305922.1_29721001_3 - 0.056 13.8 0.4 0.27 11.7 0.2 2.0 2 0 0 2 2 2 0 Prokaryotic membrane lipoprotein lipid attachment site Death PF00531.20 001305887.1_29723001_1 - 2.4e-17 62.7 0.2 5e-17 61.7 0.1 1.7 2 0 0 2 2 2 1 Death domain TNFR_c6 PF00020.16 001305887.1_29723001_1 - 5.3e-17 61.8 38.7 1.9e-09 37.6 9.1 3.7 3 0 0 3 3 3 3 TNFR/NGFR cysteine-rich region Peptidase_C8 PF03569.11 001305887.1_29723001_1 - 0.0045 16.4 0.7 0.008 15.6 0.4 1.5 2 0 0 2 2 2 1 Peptidase family C8 Stn1_C PF12659.5 001305887.1_29723001_1 - 0.065 13.0 0.1 0.16 11.8 0.1 1.6 1 1 0 1 1 1 0 Telomere capping C-terminal wHTH CABS1 PF15367.4 001319377.1_29524001_3 - 3.2e-205 681.6 46.5 3.6e-205 681.4 46.5 1.0 1 0 0 1 1 1 1 Calcium-binding and spermatid-specific protein 1 IL8 PF00048.18 001309020.1_29721001_1 - 7.9e-14 51.4 1.5 7.9e-14 51.4 1.5 1.5 2 0 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like Carb_anhydrase PF00194.19 001305891.1_29723001_1 - 5.6e-94 314.3 0.1 6.7e-94 314.0 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Sprouty PF05210.11 001319599.1_29524001_1 - 6.6e-35 119.7 34.7 1.6e-34 118.4 34.7 1.7 1 0 0 1 1 1 1 Sprouty protein (Spry) KAR9 PF08580.8 001319599.1_29524001_1 - 9.2 4.5 7.7 12 4.1 7.7 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 Maelstrom PF13017.4 001319521.1_29524001_1 - 4.3e-58 196.4 0.6 6.7e-58 195.8 0.6 1.2 1 0 0 1 1 1 1 piRNA pathway germ-plasm component HMG_box_2 PF09011.8 001319521.1_29524001_1 - 1.6e-25 89.4 0.6 1.6e-25 89.4 0.6 2.1 2 0 0 2 2 2 1 HMG-box domain AgrB PF04647.13 001319521.1_29524001_1 - 0.0087 15.3 0.9 0.019 14.2 0.9 1.5 1 0 0 1 1 1 1 Accessory gene regulator B DUF4604 PF15377.4 001319521.1_29524001_1 - 4.3 7.6 18.9 9.2 6.5 18.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) 7tm_1 PF00001.19 001009775.2_39523001_3 - 1.4e-47 162.1 24.5 1.9e-47 161.6 24.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.4 001009775.2_39523001_3 - 8.1e-12 45.3 20.3 1.3e-11 44.6 20.3 1.2 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.7 001009775.2_39523001_3 - 1.1e-11 44.5 24.9 1.5e-11 44.0 24.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.19 001309022.1_29723001_1 - 6.5e-47 159.9 24.1 1.1e-46 159.1 24.1 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001309022.1_29723001_1 - 1.4e-06 27.8 23.9 1.8e-06 27.4 23.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001309022.1_29723001_1 - 0.071 12.3 20.9 0.031 13.5 18.2 1.8 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001309022.1_29723001_1 - 1.7 8.1 20.9 11 5.5 20.9 2.4 1 1 0 1 1 1 0 Olfactory receptor 7tm_1 PF00001.19 001319382.1_29523001_1 - 1.4e-49 168.7 25.4 3.1e-49 167.5 25.4 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001319382.1_29523001_1 - 1.2e-08 34.6 23.6 1.4e-08 34.3 23.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx EF-hand_1 PF00036.30 001310577.1_31322001_1 - 1.3e-16 58.6 24.5 0.00088 18.5 0.4 7.5 7 0 0 7 7 7 6 EF hand EF-hand_7 PF13499.4 001310577.1_31322001_1 - 1.6e-16 60.4 21.9 0.0001 22.5 0.7 4.5 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.4 001310577.1_31322001_1 - 2.6e-14 51.7 19.1 0.003 17.2 0.1 7.3 7 0 0 7 7 7 5 EF-hand domain EF-hand_5 PF13202.4 001310577.1_31322001_1 - 1.6e-12 46.2 32.7 0.0025 17.1 0.6 7.1 8 0 0 8 8 8 6 EF hand EF-hand_8 PF13833.4 001310577.1_31322001_1 - 1.5e-08 34.2 10.8 0.00079 19.0 0.0 4.9 5 0 0 5 5 5 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 001310577.1_31322001_1 - 0.014 15.5 15.3 0.66 10.2 0.4 4.1 2 2 2 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region Y_phosphatase PF00102.25 001305920.1_29727001_1 - 1.8e-75 253.4 0.0 2.4e-75 253.0 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Receptor_IA-2 PF11548.6 001305920.1_29727001_1 - 9.4e-34 115.1 0.0 2.3e-33 113.9 0.0 1.7 1 0 0 1 1 1 1 Protein-tyrosine phosphatase receptor IA-2 RESP18 PF14948.4 001305920.1_29727001_1 - 3.1e-07 30.6 0.0 2.2e-06 27.9 0.0 2.6 2 0 0 2 2 2 1 RESP18 domain DSPc PF00782.18 001305920.1_29727001_1 - 0.0088 15.7 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain IL4 PF00727.16 001304911.1_01321001_1 - 2.4e-44 149.9 6.3 2.8e-44 149.7 6.3 1.1 1 0 0 1 1 1 1 Interleukin 4 p450 PF00067.20 001319483.1_29524001_3 - 2.5e-100 336.3 0.0 3.1e-100 336.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sec8_exocyst PF04048.12 001319483.1_29524001_3 - 0.057 13.2 0.2 0.11 12.3 0.2 1.3 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain Sod_Fe_C PF02777.16 001305899.1_29722001_1 - 4.9e-38 129.3 0.3 8.3e-38 128.5 0.0 1.5 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.20 001305899.1_29722001_1 - 4.8e-33 113.3 3.2 7.4e-33 112.7 3.2 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain 7tm_1 PF00001.19 001319397.1_29523001_2 - 2.4e-42 144.9 28.7 1.4e-41 142.3 28.7 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001319397.1_29523001_2 - 0.00048 19.5 25.8 0.0006 19.1 25.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx SNARE PF05739.17 001319397.1_29523001_2 - 0.21 11.5 5.8 0.41 10.5 1.6 2.9 2 0 0 2 2 2 0 SNARE domain CRAL_TRIO PF00650.18 001319392.1_29525001_3 - 6.4e-34 116.8 0.0 1e-33 116.1 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.4 001319392.1_29525001_3 - 1.1e-07 31.9 0.0 1.9e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.13 001319392.1_29525001_3 - 3.9e-06 26.8 0.0 7.8e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain p450 PF00067.20 001314145.1_09024001_1 - 1.1e-136 456.1 0.0 1.3e-136 455.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SOXp PF12336.6 001318074.1_39523001_1 - 3.4e-38 130.4 4.7 3.4e-38 130.4 4.7 2.4 4 0 0 4 4 4 1 SOX transcription factor HMG_box PF00505.17 001318074.1_39523001_1 - 1.1e-27 96.1 3.0 1.9e-27 95.3 3.0 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.8 001318074.1_39523001_1 - 8.9e-12 45.3 1.6 1.6e-11 44.5 1.6 1.4 1 0 0 1 1 1 1 HMG-box domain Cadherin PF00028.15 001168326.1_39727001_2 - 1.2e-80 266.0 0.0 7.1e-19 67.9 0.0 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001168326.1_39727001_2 - 2.2e-40 136.2 0.2 6.6e-35 118.7 0.1 4.1 4 0 0 4 4 4 2 Cadherin-like Cadherin_C_2 PF16492.3 001168326.1_39727001_2 - 5.6e-24 84.6 1.2 1.3e-23 83.5 1.2 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001168326.1_39727001_2 - 2e-08 34.1 1.4 0.006 16.5 0.0 4.8 5 0 0 5 5 5 2 Cadherin-like zf-C3HC4 PF00097.23 001300931.1_37926001_3 - 1.8e-05 24.3 7.8 1.8e-05 24.3 7.8 2.9 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001300931.1_37926001_3 - 1.9e-05 24.6 9.9 1.9e-05 24.6 9.9 4.1 3 1 0 3 3 2 2 B-box zinc finger AIP3 PF03915.11 001300931.1_37926001_3 - 5.6e-05 22.3 0.6 5.6e-05 22.3 0.6 2.0 2 0 0 2 2 2 1 Actin interacting protein 3 zf-RING_5 PF14634.4 001300931.1_37926001_3 - 0.00058 19.6 10.8 0.00058 19.6 10.8 3.5 3 0 0 3 3 3 1 zinc-RING finger domain DUF3583 PF12126.6 001300931.1_37926001_3 - 0.0038 16.6 4.2 0.0038 16.6 4.2 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3583) zf-C3HC4_3 PF13920.4 001300931.1_37926001_3 - 0.0092 15.7 10.5 0.0092 15.7 10.5 3.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.4 001300931.1_37926001_3 - 0.0095 15.9 9.6 0.0095 15.9 9.6 3.5 3 1 1 4 4 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.4 001300931.1_37926001_3 - 0.012 15.4 9.8 0.012 15.4 9.8 3.2 3 0 0 3 3 2 0 Prokaryotic RING finger family 4 MAD PF05557.11 001300931.1_37926001_3 - 0.012 13.9 0.1 0.012 13.9 0.1 2.3 2 1 0 2 2 2 0 Mitotic checkpoint protein IL10 PF00726.15 001300931.1_37926001_3 - 0.018 14.4 0.2 0.066 12.6 0.2 2.0 1 1 0 1 1 1 0 Interleukin 10 ARA70 PF12489.6 001300931.1_37926001_3 - 0.033 14.2 0.2 0.073 13.1 0.2 1.5 1 0 0 1 1 1 0 Nuclear coactivator Exonuc_VII_L PF02601.13 001300931.1_37926001_3 - 0.55 9.6 9.0 0.28 10.6 1.2 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit DivIVA PF05103.11 001300931.1_37926001_3 - 6 6.8 16.0 7.5 6.5 7.8 2.6 2 1 0 2 2 2 0 DivIVA protein Orn_Arg_deC_N PF02784.14 001132849.2_43529001_2 - 3.7e-64 216.4 0.1 4.7e-64 216.1 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.20 001132849.2_43529001_2 - 2.9e-24 85.2 0.0 5e-24 84.4 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain RasGEF PF00617.17 175211.5_32929001_2 - 1e-48 165.7 1.9 3e-48 164.1 1.2 1.9 1 1 1 2 2 2 1 RasGEF domain PH PF00169.27 175211.5_32929001_2 - 1.3e-10 41.6 0.0 2.4e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 PH domain Prion PF00377.16 001304886.1_01322001_1 - 4.3e-37 126.4 1.9 5.4e-37 126.1 1.9 1.1 1 0 0 1 1 1 1 Prion/Doppel alpha-helical domain Prion_bPrPp PF11587.6 001304886.1_01322001_1 - 4.8e-19 67.7 1.5 9.1e-19 66.9 1.5 1.5 1 0 0 1 1 1 1 Major prion protein bPrPp - N terminal Ig_2 PF13895.4 001290316.1_32927001_1 - 1.2e-23 83.1 0.0 2.7e-15 56.3 0.0 5.0 5 0 0 5 5 5 2 Immunoglobulin domain Ig_3 PF13927.4 001290316.1_32927001_1 - 6.4e-22 77.8 0.0 1.1e-06 29.0 0.0 4.9 5 0 0 5 5 5 4 Immunoglobulin domain I-set PF07679.14 001290316.1_32927001_1 - 2.4e-15 56.2 0.0 0.00087 19.2 0.0 5.0 4 1 0 4 4 4 4 Immunoglobulin I-set domain ig PF00047.23 001290316.1_32927001_1 - 7.5e-09 35.5 0.0 0.0019 18.2 0.0 4.8 5 1 0 5 5 5 2 Immunoglobulin domain V-set PF07686.15 001290316.1_32927001_1 - 1.2e-05 25.3 0.0 3.3 7.8 0.0 4.5 4 2 1 5 5 5 2 Immunoglobulin V-set domain C2-set_2 PF08205.10 001290316.1_32927001_1 - 0.00049 20.0 3.7 4.1 7.4 0.0 4.7 5 0 0 5 5 5 2 CD80-like C2-set immunoglobulin domain DUF4690 PF15756.3 001290316.1_32927001_1 - 0.008 16.6 0.1 0.019 15.5 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4690) CYYR1 PF10873.6 001290316.1_32927001_1 - 0.029 14.7 0.1 0.067 13.5 0.1 1.6 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 Herpes_gE PF02480.14 001290316.1_32927001_1 - 0.1 11.2 0.0 0.3 9.6 0.0 1.6 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E DUF4514 PF14986.4 001290316.1_32927001_1 - 1.4 8.8 3.0 2.8 7.8 3.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4514) Reprolysin PF01421.17 001310440.1_32929001_3 - 1.4e-62 211.0 0.1 1.4e-62 211.0 0.1 2.0 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.17 001310440.1_32929001_3 - 7.4e-27 94.2 0.6 1.4e-26 93.3 0.6 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_CR PF08516.10 001310440.1_32929001_3 - 1.7e-25 89.6 7.6 1.7e-25 89.6 7.6 3.1 3 0 0 3 3 3 1 ADAM cysteine-rich Disintegrin PF00200.21 001310440.1_32929001_3 - 5e-15 55.9 30.1 5e-15 55.9 30.1 4.8 5 0 0 5 5 5 1 Disintegrin Reprolysin_3 PF13582.4 001310440.1_32929001_3 - 5.3e-09 36.5 0.0 1.2e-08 35.4 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.11 001310440.1_32929001_3 - 2e-05 24.7 10.6 2e-05 24.7 10.6 5.3 4 1 0 4 4 4 1 EGF-like domain Reprolysin_2 PF13574.4 001310440.1_32929001_3 - 0.016 15.0 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Carb_anhydrase PF00194.19 178396.5_32928001_2 - 8.7e-91 303.8 0.1 1.1e-90 303.5 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase ShK PF01549.22 178396.5_32928001_3 - 5.7 7.4 10.4 0.35 11.3 0.5 3.3 3 0 0 3 3 3 0 ShK domain-like Insulin PF00049.16 001310554.1_31322001_1 - 3.7e-13 50.2 1.3 1.9e-12 47.9 1.3 1.9 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family Zf_RING PF16744.3 001310554.1_31322001_2 - 0.046 13.7 1.1 0.046 13.7 1.1 1.7 2 0 0 2 2 2 0 KIAA1045 RING finger TPR_2 PF07719.15 001032932.2_29623001_1 - 5.5e-10 38.5 1.3 0.0013 18.6 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat FKBP_C PF00254.26 001032932.2_29623001_1 - 5.2e-05 23.4 0.0 0.00024 21.2 0.0 2.0 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.26 001032932.2_29623001_1 - 7.2e-05 22.3 1.4 0.94 9.3 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.4 001032932.2_29623001_1 - 0.00026 20.8 0.2 0.17 12.0 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.4 001032932.2_29623001_1 - 0.00064 19.2 1.8 0.0013 18.3 0.2 2.1 2 0 0 2 2 2 1 TPR repeat TPR_12 PF13424.4 001032932.2_29623001_1 - 0.0041 17.2 1.0 0.53 10.5 0.0 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.5 001032932.2_29623001_1 - 0.012 15.6 3.0 0.21 11.7 1.7 3.0 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 CDC37_N PF03234.12 001032932.2_29623001_1 - 0.097 13.4 0.0 0.19 12.5 0.0 1.5 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding TPR_10 PF13374.4 001032932.2_29623001_1 - 0.31 10.8 2.9 1.8 8.4 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Hormone_3 PF00159.16 001193429.2_29621001_1 - 4.3e-17 61.8 2.5 6.4e-17 61.2 2.5 1.3 1 0 0 1 1 1 1 Pancreatic hormone peptide Na_H_Exchanger PF00999.19 001319594.1_29524001_2 - 5e-29 101.1 35.6 7e-29 100.6 35.6 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Gate PF07670.12 001319594.1_29524001_2 - 0.43 10.7 6.0 1.8 8.7 0.6 2.9 2 1 0 2 2 2 0 Nucleoside recognition Hormone_1 PF00103.18 001304927.1_01322001_1 - 1.1e-46 159.2 0.0 1.2e-46 159.0 0.0 1.0 1 0 0 1 1 1 1 Somatotropin hormone family Kinesin PF00225.21 001319453.1_29525001_1 - 1.9e-121 404.9 0.1 4.4e-121 403.7 0.1 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.3 001319453.1_29525001_1 - 4e-27 94.9 0.1 2.2e-26 92.4 0.0 2.3 2 0 0 2 2 2 1 Microtubule binding AAA_22 PF13401.4 001319453.1_29525001_1 - 0.033 14.3 4.9 1.9 8.6 0.0 3.3 2 1 0 2 2 2 0 AAA domain DUF1492 PF07374.9 001319453.1_29525001_1 - 2.9 8.0 8.8 2 8.5 0.7 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1492) IL2 PF00715.15 001304871.1_01321001_1 - 4.6e-75 250.3 5.7 5.2e-75 250.1 5.7 1.0 1 0 0 1 1 1 1 Interleukin 2 SOCS_box PF07525.14 001319362.1_29523001_3 - 1.6e-09 37.8 2.2 3.9e-09 36.6 2.2 1.7 1 0 0 1 1 1 1 SOCS box Ank_2 PF12796.5 001319362.1_29523001_3 - 0.00017 22.0 0.0 0.00087 19.7 0.0 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001319362.1_29523001_3 - 0.0026 18.2 0.0 0.016 15.7 0.0 2.1 1 1 0 1 1 1 1 Ankyrin repeats (many copies) HTH_Mga PF08280.9 001319362.1_29523001_3 - 0.0066 16.3 0.1 0.062 13.2 0.1 2.5 1 1 1 2 2 2 1 M protein trans-acting positive regulator (MGA) HTH domain Ank_3 PF13606.4 001319362.1_29523001_3 - 0.042 14.3 0.0 14 6.5 0.0 2.8 2 0 0 2 2 2 0 Ankyrin repeat 7tm_1 PF00001.19 001278566.1_39526001_1 - 3.9e-30 104.9 19.8 5.8e-30 104.3 19.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.4 001278566.1_39526001_1 - 3.5e-16 58.6 3.0 0.00054 19.6 0.2 4.6 3 2 1 4 4 4 4 Leucine rich repeat LRR_5 PF13306.4 001278566.1_39526001_1 - 1.8e-12 47.2 11.5 1.3e-07 31.5 1.7 3.3 1 1 1 3 3 3 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 001278566.1_39526001_1 - 0.084 13.2 5.0 2.4 8.5 0.2 3.8 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) Peptidase_M14 PF00246.22 025350.4_32924001_1 - 4.3e-94 315.4 0.0 5.4e-94 315.1 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.14 025350.4_32924001_1 - 3.7e-22 78.4 0.2 9.7e-22 77.0 0.2 1.8 1 0 0 1 1 1 1 Carboxypeptidase activation peptide PAP2 PF01569.19 181634.3_45725001_3 - 7.8e-14 51.5 6.0 1.5e-13 50.6 6.0 1.4 1 0 0 1 1 1 1 PAP2 superfamily DUF4746 PF15928.3 181634.3_45725001_3 - 0.2 10.9 5.3 0.33 10.2 5.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) EBV-NA3 PF05009.10 181634.3_45725001_3 - 1.8 7.9 4.4 3 7.2 4.4 1.3 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) RNA_pol_3_Rpc31 PF11705.6 181634.3_45725001_3 - 3.5 7.7 9.0 6 6.9 9.0 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Radial_spoke PF04712.10 181634.3_45725001_3 - 4 6.1 11.9 5.9 5.6 11.9 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein CENP-B_dimeris PF09026.8 181634.3_45725001_3 - 5.3 7.4 9.4 11 6.4 9.4 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain ELO PF01151.16 001319414.1_29526001_3 - 3.1e-63 213.5 22.6 5.1e-63 212.8 22.6 1.3 1 0 0 1 1 1 1 GNS1/SUR4 family IL2 PF00715.15 001305898.1_29721001_1 - 2.1e-80 267.6 6.5 2.3e-80 267.5 6.5 1.0 1 0 0 1 1 1 1 Interleukin 2 Plasmid_RAQPRD PF09686.8 001305898.1_29721001_1 - 0.0024 17.9 0.1 0.027 14.5 0.0 2.1 2 0 0 2 2 2 1 Plasmid protein of unknown function (Plasmid_RAQPRD) CBM9_2 PF16011.3 001024871.1_45724001_1 - 0.079 12.5 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Carbohydrate-binding family 9 Kelch_3 PF13415.4 001024871.1_45724001_3 - 1.8e-33 114.0 15.4 3.4e-09 36.6 0.1 6.6 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_4 PF13418.4 001024871.1_45724001_3 - 1.6e-29 101.5 5.6 5.2e-06 26.2 0.0 6.8 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_6 PF13964.4 001024871.1_45724001_3 - 3.6e-29 99.9 1.1 1e-05 25.5 0.0 5.8 4 1 1 5 5 5 5 Kelch motif Kelch_2 PF07646.13 001024871.1_45724001_3 - 4.2e-29 99.3 9.3 5.2e-14 51.4 0.0 6.6 7 1 0 7 7 7 5 Kelch motif Kelch_1 PF01344.23 001024871.1_45724001_3 - 1.3e-28 98.1 1.7 1.1e-08 34.4 0.1 6.0 6 0 0 6 6 6 5 Kelch motif Kelch_5 PF13854.4 001024871.1_45724001_3 - 1.4e-28 98.2 9.9 1e-05 25.3 0.1 7.2 7 0 0 7 7 7 6 Kelch motif 7tm_1 PF00001.19 001301843.1_08025001_1 - 1.2e-29 103.3 23.4 1.8e-29 102.7 23.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.4 001301843.1_08025001_1 - 1.9e-18 65.9 3.0 3e-05 23.5 0.2 4.8 2 2 3 5 5 5 5 Leucine rich repeat LRR_5 PF13306.4 001301843.1_08025001_1 - 5.9e-14 52.0 2.2 2.3e-07 30.7 0.7 2.3 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_4 PF12799.5 001301843.1_08025001_1 - 0.086 13.1 4.9 2 8.8 0.2 3.7 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) Comm PF15957.3 001301843.1_08025001_1 - 0.17 12.1 0.8 0.42 10.9 0.8 1.7 1 0 0 1 1 1 0 Commissureless GHBP PF12772.5 001304890.1_01324001_1 - 5.9e-135 449.4 1.6 7.5e-135 449.1 1.6 1.1 1 0 0 1 1 1 1 Growth hormone receptor binding EpoR_lig-bind PF09067.8 001304890.1_01324001_1 - 1.4e-11 44.4 1.4 3.1e-11 43.3 0.8 1.9 2 0 0 2 2 2 1 Erythropoietin receptor, ligand binding fn3 PF00041.19 001304890.1_01324001_1 - 2e-07 31.1 0.3 4.8e-07 29.9 0.3 1.7 1 0 0 1 1 1 1 Fibronectin type III domain DUF4605 PF15378.4 001304890.1_01324001_1 - 0.054 13.2 2.9 0.1 12.4 2.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4605) TGF_beta PF00019.18 001308579.1_39523001_1 - 6e-14 52.7 0.1 1.7e-13 51.3 0.1 1.7 1 1 0 1 1 1 1 Transforming growth factor beta like domain Rhomboid PF01694.20 001191822.1_45724001_2 - 2e-35 121.9 8.5 3.2e-35 121.2 8.5 1.3 1 0 0 1 1 1 1 Rhomboid family HPP PF04982.11 001191822.1_45724001_2 - 0.072 13.2 0.1 0.072 13.2 0.1 2.5 1 1 2 3 3 3 0 HPP family DUF3402 PF11882.6 001319602.1_29527001_2 - 5.7e-103 345.4 26.1 9.3e-67 226.0 4.8 3.4 2 1 2 4 4 4 3 Domain of unknown function (DUF3402) N1221 PF07923.11 001319602.1_29527001_2 - 1e-51 175.7 0.0 1.7e-51 175.0 0.0 1.3 1 0 0 1 1 1 1 N1221-like protein ELM2 PF01448.22 001319602.1_29527001_2 - 0.088 13.5 0.5 0.24 12.0 0.5 1.8 1 0 0 1 1 1 0 ELM2 domain zf-H2C2_2 PF13465.4 009566.5_32929001_1 - 3.8e-44 147.1 42.7 7.7e-08 32.3 0.1 10.7 10 0 0 10 10 10 7 Zinc-finger double domain zf-C2H2 PF00096.24 009566.5_32929001_1 - 3.8e-42 140.3 47.9 3.4e-06 27.1 0.3 11.0 9 0 0 9 9 9 8 Zinc finger, C2H2 type KRAB PF01352.25 009566.5_32929001_1 - 2.7e-21 74.8 0.6 5.7e-21 73.8 0.6 1.6 1 0 0 1 1 1 1 KRAB box zf-C2H2_4 PF13894.4 009566.5_32929001_1 - 9.7e-17 60.1 68.6 0.029 15.0 0.3 11.4 11 0 0 11 11 9 8 C2H2-type zinc finger zf-C2H2_6 PF13912.4 009566.5_32929001_1 - 2.7e-15 55.8 38.5 0.0067 16.2 0.2 8.3 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 009566.5_32929001_1 - 7.5e-10 38.7 13.6 0.54 10.5 0.0 7.5 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.8 009566.5_32929001_1 - 2e-07 30.9 32.0 0.023 14.7 1.3 6.4 4 1 3 7 7 7 4 Zinc ribbon domain XPA_N PF01286.16 009566.5_32929001_1 - 0.0022 17.9 27.9 5.1 7.1 0.2 8.3 8 0 0 8 8 8 1 XPA protein N-terminal DZR PF12773.5 009566.5_32929001_1 - 0.031 14.2 26.4 2.9 7.8 4.2 5.3 3 1 1 4 4 3 0 Double zinc ribbon ADK_lid PF05191.12 009566.5_32929001_1 - 0.41 10.6 16.9 0.51 10.3 0.9 5.2 5 1 1 6 6 6 0 Adenylate kinase, active site lid PknG_rubred PF16919.3 009566.5_32929001_1 - 0.42 10.6 13.5 0.87 9.6 0.1 4.7 3 1 1 5 5 4 0 Protein kinase G rubredoxin domain zf-met PF12874.5 009566.5_32929001_1 - 1 9.7 28.6 9.6 6.6 0.2 7.9 7 0 0 7 7 7 0 Zinc-finger of C2H2 type FYVE PF01363.19 009566.5_32929001_1 - 3.1 7.9 21.7 43 4.2 9.2 5.1 2 1 1 3 3 2 0 FYVE zinc finger zf-C2HE PF16278.3 009566.5_32929001_1 - 6.9 7.1 34.9 35 4.8 2.9 8.3 3 2 3 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger DUF3268 PF11672.6 009566.5_32929001_1 - 7.5 6.8 10.6 5.6 7.2 0.1 3.7 4 0 0 4 4 4 0 zinc-finger-containing domain zinc_ribbon_15 PF17032.3 009566.5_32929001_1 - 8.7 7.0 29.0 0.92 10.2 0.7 5.5 4 2 2 6 6 4 0 zinc-ribbon family Cadherin PF00028.15 001082556.2_39729001_2 - 4.6e-83 273.7 0.4 8.3e-18 64.5 0.0 6.2 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001082556.2_39729001_2 - 4.5e-35 119.2 0.3 6e-32 109.2 0.0 4.3 5 1 1 6 6 6 1 Cadherin-like Cadherin_C_2 PF16492.3 001082556.2_39729001_2 - 2.7e-26 92.0 0.3 6.1e-26 90.9 0.3 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_tail PF15974.3 001082556.2_39729001_2 - 2e-25 89.5 3.3 4.1e-25 88.5 3.3 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_3 PF16184.3 001082556.2_39729001_2 - 2e-06 27.6 5.0 0.58 10.1 0.1 4.5 4 0 0 4 4 4 3 Cadherin-like Asp PF00026.21 001172937.2_09923001_3 - 8.5e-122 406.3 0.1 1e-121 406.1 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001172937.2_09923001_3 - 3.9e-15 56.4 3.9 1.2e-11 45.1 0.1 2.4 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001172937.2_09923001_3 - 7e-07 28.8 0.7 1.2e-06 28.1 0.7 1.4 1 0 0 1 1 1 1 A1 Propeptide Cadherin PF00028.15 001082592.2_39729001_1 - 1.1e-80 266.0 0.3 2.4e-19 69.4 0.0 6.3 6 0 0 6 6 6 5 Cadherin domain Cadherin_tail PF15974.3 001082592.2_39729001_1 - 2.3e-63 212.3 4.7 4.1e-63 211.5 4.7 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 001082592.2_39729001_1 - 3.9e-28 97.9 0.1 9.8e-28 96.6 0.1 1.8 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_2 PF08266.10 001082592.2_39729001_1 - 5.2e-25 86.9 0.1 5.2e-22 77.3 0.0 4.3 5 0 0 5 5 5 1 Cadherin-like Cadherin_3 PF16184.3 001082592.2_39729001_1 - 0.0019 18.1 4.9 5.2 7.0 0.0 5.0 5 0 0 5 5 5 1 Cadherin-like He_PIG PF05345.10 001082592.2_39729001_1 - 4.9 7.3 5.8 4.6 7.4 0.1 3.8 5 0 0 5 5 5 0 Putative Ig domain DUF4820 PF16091.3 001082592.2_39729001_1 - 8.8 5.5 13.7 0.97 8.6 5.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Cadherin PF00028.15 001082571.2_39729001_3 - 1.5e-80 265.6 0.0 2.9e-16 59.6 0.0 6.2 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001082571.2_39729001_3 - 7.5e-31 105.6 0.9 4.3e-28 96.8 0.1 3.2 3 0 0 3 3 3 2 Cadherin-like Cadherin_tail PF15974.3 001082571.2_39729001_3 - 1.8e-25 89.7 3.3 4e-25 88.5 3.3 1.5 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 001082571.2_39729001_3 - 4.6e-15 56.0 0.1 1.3e-14 54.6 0.0 1.8 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal Microcephalin PF12258.6 001009010.2_39726001_1 - 2.8e-171 569.9 19.9 2.8e-171 569.9 19.9 1.9 2 0 0 2 2 2 1 Microcephalin protein PTCB-BRCT PF12738.5 001009010.2_39726001_1 - 1.7e-18 66.2 3.0 1.1e-17 63.5 1.5 2.6 2 0 0 2 2 2 1 twin BRCT domain BRCT PF00533.24 001009010.2_39726001_1 - 5.3e-15 55.5 0.1 1.8e-05 25.0 0.2 3.7 3 0 0 3 3 3 3 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.3 001009010.2_39726001_1 - 2.5e-14 53.3 0.1 8.1e-07 29.2 0.0 3.3 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.3 001009010.2_39726001_1 - 0.035 14.3 3.2 0.045 13.9 0.4 2.5 3 0 0 3 3 3 0 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.3 001009010.2_39726001_1 - 0.078 12.7 0.1 7.5 6.4 0.0 3.5 4 0 0 4 4 4 0 Regulator of Ty1 transposition protein 107 BRCT domain Spectrin PF00435.19 001009010.2_39726001_1 - 0.26 11.6 3.9 12 6.3 0.1 2.8 3 0 0 3 3 3 0 Spectrin repeat COesterase PF00135.26 001357509.1_49827001_1 - 2.3e-178 594.1 0.0 2.8e-178 593.9 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family AChE_tetra PF08674.8 001357509.1_49827001_1 - 8.2e-23 79.7 9.1 8.2e-23 79.7 9.1 2.2 2 0 0 2 2 2 1 Acetylcholinesterase tetramerisation domain Abhydrolase_3 PF07859.11 001357509.1_49827001_1 - 2.5e-06 27.4 0.0 4.2e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Lectin_C PF00059.19 001012648.1_45722001_3 - 0.00012 22.7 2.8 0.00012 22.7 2.8 2.3 2 1 0 2 2 2 1 Lectin C-type domain LRR_4 PF12799.5 001013626.3_26224001_2 - 5.6e-15 55.0 35.1 1.9e-09 37.5 1.6 5.4 3 2 2 5 5 5 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001013626.3_26224001_2 - 6.9e-11 41.8 12.7 9.4e-06 25.1 2.7 2.6 2 1 0 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.4 001013626.3_26224001_2 - 1.8e-08 33.9 25.0 6.9e-05 22.4 5.3 5.1 3 1 3 6 6 6 5 Leucine rich repeat LRR_1 PF00560.31 001013626.3_26224001_2 - 1.3 9.7 28.0 2.3 8.9 2.1 7.2 7 0 0 7 7 7 0 Leucine Rich Repeat EGF_CA PF07645.13 001277341.1_45724001_3 - 2.3e-48 162.0 84.4 4e-11 42.8 6.1 8.1 8 0 0 8 8 8 6 Calcium-binding EGF domain cEGF PF12662.5 001277341.1_45724001_3 - 8.3e-37 124.6 53.5 4e-10 39.3 0.4 7.6 8 0 0 8 8 8 6 Complement Clr-like EGF-like FXa_inhibition PF14670.4 001277341.1_45724001_3 - 1.1e-13 51.1 91.8 1.5e-06 28.3 7.6 8.7 8 1 0 8 8 8 4 Coagulation Factor Xa inhibitory site EGF_3 PF12947.5 001277341.1_45724001_3 - 4.5e-07 29.8 66.0 9.7e-05 22.4 6.4 7.3 7 1 0 7 7 7 4 EGF domain EGF PF00008.25 001277341.1_45724001_3 - 0.00012 22.1 88.0 0.0013 18.9 7.9 8.3 8 0 0 8 8 8 4 EGF-like domain hEGF PF12661.5 001277341.1_45724001_3 - 0.0034 17.9 24.4 0.0054 17.2 4.0 10.2 11 0 0 11 11 11 5 Human growth factor-like EGF Adipogenin PF15202.4 001277341.1_45724001_3 - 0.056 13.3 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 Adipogenin Macoilin PF09726.7 001038647.1_06527001_3 - 0 1114.4 18.3 0 1114.1 18.3 1.0 1 0 0 1 1 1 1 Transmembrane protein DUF812 PF05667.9 001038647.1_06527001_3 - 0.00047 19.1 39.1 0.00047 19.1 39.1 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF812) Reo_sigmaC PF04582.10 001038647.1_06527001_3 - 0.0042 16.4 7.8 0.12 11.6 0.5 2.2 2 0 0 2 2 2 2 Reovirus sigma C capsid protein GLE1 PF07817.11 001038647.1_06527001_3 - 1.2 8.1 12.7 0.91 8.5 0.1 2.3 2 0 0 2 2 2 0 GLE1-like protein Macoilin PF09726.7 001038646.1_49825001_1 - 0 1117.0 18.3 0 1116.8 18.3 1.0 1 0 0 1 1 1 1 Transmembrane protein DUF812 PF05667.9 001038646.1_49825001_1 - 0.00022 20.1 38.9 0.00022 20.1 38.9 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF812) Reo_sigmaC PF04582.10 001038646.1_49825001_1 - 0.0015 17.9 7.7 0.072 12.3 0.6 2.2 2 0 0 2 2 2 2 Reovirus sigma C capsid protein GLE1 PF07817.11 001038646.1_49825001_1 - 0.63 9.1 12.9 0.66 9.0 0.1 2.3 2 0 0 2 2 2 0 GLE1-like protein FPP PF05911.9 001038646.1_49825001_1 - 5.3 5.0 55.4 0.2 9.7 29.3 2.4 2 1 1 3 3 3 0 Filament-like plant protein, long coiled-coil Ribosomal_L1 PF00687.19 001357628.1_32922001_1 - 3.3e-36 124.8 1.7 4.1e-36 124.5 1.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF3671 PF12420.6 001357628.1_32922001_1 - 0.034 14.1 0.6 0.052 13.5 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function zf-C2H2 PF00096.24 104257.1_26229120_1 - 6.8e-08 32.4 20.0 0.00012 22.3 1.2 5.2 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.6 104257.1_26229120_1 - 5e-07 29.7 12.8 0.082 13.1 0.5 4.7 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.4 104257.1_26229120_1 - 3.9e-05 23.8 14.4 0.0025 18.1 0.7 4.8 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.4 104257.1_26229120_1 - 7.9e-05 23.0 30.5 0.0015 19.1 0.5 6.1 6 0 0 6 6 6 3 C2H2-type zinc finger SET PF00856.26 104257.1_26229120_1 - 0.021 15.1 0.0 0.038 14.2 0.0 1.4 1 0 0 1 1 1 0 SET domain zf-C2H2_2 PF12756.5 104257.1_26229120_1 - 2.3 8.4 11.2 11 6.3 2.6 3.6 2 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) DUF629 PF04780.10 104257.1_26229120_1 - 4.3 5.6 7.2 36 2.6 5.4 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF629) zf-C2H2 PF00096.24 104257.1_26229120_3 - 9.9e-29 98.0 98.2 1.5e-05 25.1 1.1 14.0 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 104257.1_26229120_3 - 2.7e-26 89.8 102.1 0.0024 18.4 1.1 14.1 14 0 0 14 14 14 12 C2H2-type zinc finger zf-H2C2_2 PF13465.4 104257.1_26229120_3 - 4.1e-23 80.6 79.6 2.5e-05 24.4 0.5 12.6 12 0 0 12 12 12 8 Zinc-finger double domain zf-met PF12874.5 104257.1_26229120_3 - 2.1e-10 40.5 65.9 0.1 12.9 0.4 11.9 12 0 0 12 12 12 9 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 104257.1_26229120_3 - 6.6e-08 32.5 61.8 0.011 15.9 0.1 12.1 13 0 0 13 13 13 6 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.4 104257.1_26229120_3 - 0.017 14.9 34.2 0.049 13.4 0.2 8.0 8 0 0 8 8 8 0 zinc-finger of a C2HC-type Cpn60_TCP1 PF00118.22 072977.1_26224120_3 - 1.1e-43 149.5 0.0 1.4e-43 149.2 0.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family ADH_zinc_N PF00107.24 151773.1_32925120_1 - 3.2e-28 98.1 0.4 6.5e-28 97.1 0.1 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.4 151773.1_32925120_1 - 1.4e-17 64.8 0.0 2.2e-17 64.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.10 151773.1_32925120_1 - 1.4e-11 44.1 0.0 3.3e-11 42.9 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.23 151773.1_32925120_1 - 0.065 12.6 0.3 0.1 11.9 0.3 1.3 1 0 0 1 1 1 0 short chain dehydrogenase G-patch PF01585.21 151741.1_32929120_3 - 2.5e-16 59.2 1.6 4.6e-16 58.3 1.6 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.5 151741.1_32929120_3 - 1.4e-07 31.3 0.2 3.8e-07 30.0 0.2 1.6 1 0 0 1 1 1 1 G-patch domain Cadherin PF00028.15 001082587.2_39729001_1 - 3.8e-70 232.3 0.0 5.6e-15 55.4 0.0 6.4 6 0 0 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 001082587.2_39729001_1 - 2.5e-63 212.2 4.7 4.3e-63 211.4 4.7 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 001082587.2_39729001_1 - 4.1e-29 100.1 0.1 1.4e-27 95.2 0.1 3.2 4 0 0 4 4 4 1 Cadherin-like Cadherin_C_2 PF16492.3 001082587.2_39729001_1 - 4.8e-06 27.1 0.1 1.3e-05 25.8 0.1 1.8 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001082587.2_39729001_1 - 0.00018 21.3 1.6 1.5 8.8 0.1 3.9 4 0 0 4 4 4 2 Cadherin-like Hormone_1 PF00103.18 001329075.1_37922001_1 - 1.3e-44 152.4 0.0 1.5e-44 152.2 0.0 1.0 1 0 0 1 1 1 1 Somatotropin hormone family Cadherin PF00028.15 001082583.2_39729001_3 - 1.4e-79 262.5 0.0 5.7e-20 71.4 0.1 6.4 6 0 0 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 001082583.2_39729001_3 - 1.9e-63 212.6 4.7 3.6e-63 211.7 4.7 1.5 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 001082583.2_39729001_3 - 8e-31 105.6 2.2 1.1e-28 98.8 0.1 4.1 5 0 0 5 5 5 1 Cadherin-like Cadherin_C_2 PF16492.3 001082583.2_39729001_3 - 3e-06 27.8 0.0 1.2e-05 25.8 0.0 2.1 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001082583.2_39729001_3 - 0.0016 18.3 4.0 2.1 8.3 0.2 4.5 3 1 1 4 4 4 1 Cadherin-like Cadherin PF00028.15 001082544.2_39729001_1 - 2.2e-78 258.7 0.0 2.2e-15 56.7 0.0 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001082544.2_39729001_1 - 3.5e-34 116.3 0.5 6.9e-33 112.2 0.0 3.4 5 0 0 5 5 5 1 Cadherin-like Cadherin_C_2 PF16492.3 001082544.2_39729001_1 - 6.6e-26 90.8 0.1 1.3e-25 89.8 0.1 1.5 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_tail PF15974.3 001082544.2_39729001_1 - 1.8e-25 89.6 3.3 3.8e-25 88.6 3.3 1.5 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_3 PF16184.3 001082544.2_39729001_1 - 0.00053 19.8 2.4 7.7 6.4 0.0 4.5 4 0 0 4 4 4 1 Cadherin-like TMEM154 PF15102.4 001082544.2_39729001_1 - 0.12 12.1 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family HCR PF07111.10 001009009.3_39726001_3 - 0 1472.5 108.7 0 1472.3 108.7 1.0 1 0 0 1 1 1 1 Alpha helical coiled-coil rod protein (HCR) SpoVIF PF14069.4 001009009.3_39726001_3 - 0.17 11.6 7.4 0.036 13.7 1.7 2.8 3 0 0 3 3 3 0 Stage VI sporulation protein F Cadherin PF00028.15 001082558.2_39729001_2 - 5.3e-80 263.8 0.0 3.5e-18 65.7 0.0 6.2 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001082558.2_39729001_2 - 3.9e-30 103.4 0.0 3e-28 97.3 0.1 3.5 4 0 0 4 4 4 1 Cadherin-like Cadherin_tail PF15974.3 001082558.2_39729001_2 - 4.4e-26 91.7 3.2 4.1e-25 88.5 3.3 2.3 2 0 0 2 2 2 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 001082558.2_39729001_2 - 2.3e-15 57.0 0.0 4.8e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal zf-AN1 PF01428.14 025512.3_32924001_1 - 1.6e-21 76.1 34.3 4.6e-12 45.8 8.5 3.3 4 0 0 4 4 4 2 AN1-like Zinc finger Filament PF00038.19 001111257.2_49827001_3 - 5.7e-98 328.2 54.6 7.6e-98 327.8 54.6 1.2 1 0 0 1 1 1 1 Intermediate filament protein LTD PF00932.17 001111257.2_49827001_3 - 2e-17 63.4 0.0 3.7e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 Lamin Tail Domain HAUS-augmin3 PF14932.4 001111257.2_49827001_3 - 0.0024 17.3 6.2 0.0024 17.3 6.2 3.9 1 1 2 3 3 2 1 HAUS augmin-like complex subunit 3 TPR_MLP1_2 PF07926.10 001111257.2_49827001_3 - 0.0033 17.3 57.9 0.24 11.3 24.5 4.0 1 1 3 4 4 4 3 TPR/MLP1/MLP2-like protein Reo_sigmaC PF04582.10 001111257.2_49827001_3 - 0.0046 16.3 14.5 0.023 14.0 0.5 3.2 1 1 2 3 3 3 3 Reovirus sigma C capsid protein Fez1 PF06818.13 001111257.2_49827001_3 - 0.0066 16.8 25.5 0.0066 16.8 25.5 3.3 1 1 2 3 3 3 1 Fez1 IncA PF04156.12 001111257.2_49827001_3 - 0.025 14.2 69.9 0.17 11.5 21.1 3.9 1 1 2 3 3 3 0 IncA protein Tht1 PF04163.10 001111257.2_49827001_3 - 0.072 11.7 7.0 0.11 11.1 7.0 1.2 1 0 0 1 1 1 0 Tht1-like nuclear fusion protein Spc7 PF08317.9 001111257.2_49827001_3 - 0.3 9.8 50.5 0.26 10.0 17.8 3.3 1 1 2 3 3 3 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.7 001111257.2_49827001_3 - 4.2 7.3 56.4 1 9.2 10.8 3.6 1 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3584 PF12128.6 001111257.2_49827001_3 - 5.7 4.2 51.6 17 2.6 51.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Cadherin PF00028.15 001082559.2_39729001_1 - 4.1e-79 261.0 0.0 2e-16 60.1 0.0 6.3 5 1 1 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001082559.2_39729001_1 - 2.3e-37 126.5 0.2 5.6e-33 112.5 0.0 4.0 5 0 0 5 5 5 2 Cadherin-like Cadherin_tail PF15974.3 001082559.2_39729001_1 - 1.9e-25 89.6 3.3 4.1e-25 88.5 3.3 1.5 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 001082559.2_39729001_1 - 4.8e-25 88.0 0.1 1.2e-24 86.7 0.1 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001082559.2_39729001_1 - 0.0015 18.4 3.0 1.5 8.7 0.3 4.4 4 0 0 4 4 4 1 Cadherin-like TMEM154 PF15102.4 001082559.2_39729001_1 - 0.067 13.0 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family Cadherin PF00028.15 001082555.2_39729001_1 - 1.9e-80 265.3 0.0 1.7e-18 66.7 0.0 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001082555.2_39729001_1 - 5.8e-36 122.0 0.0 8.8e-33 111.8 0.0 4.6 6 0 0 6 6 6 1 Cadherin-like Cadherin_C_2 PF16492.3 001082555.2_39729001_1 - 4.5e-26 91.3 0.2 9.4e-26 90.3 0.2 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_tail PF15974.3 001082555.2_39729001_1 - 1.9e-25 89.6 3.3 4e-25 88.6 3.3 1.5 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_3 PF16184.3 001082555.2_39729001_1 - 0.00021 21.2 5.2 0.67 9.9 0.0 4.9 4 1 0 4 4 4 2 Cadherin-like Cadherin_pro PF08758.9 001082555.2_39729001_1 - 0.096 12.7 0.0 3.2 7.8 0.0 2.8 2 1 0 2 2 2 0 Cadherin prodomain like Rhomboid PF01694.20 001357037.1_32929001_1 - 1.5e-18 67.0 5.7 2.2e-18 66.5 5.7 1.2 1 0 0 1 1 1 1 Rhomboid family Cadherin PF00028.15 001013009.3_39727001_1 - 1.4e-78 259.3 0.0 6.4e-18 64.9 0.0 6.4 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001013009.3_39727001_1 - 3.2e-37 126.1 0.3 2.7e-34 116.7 0.1 3.7 4 0 0 4 4 4 2 Cadherin-like Cadherin_C_2 PF16492.3 001013009.3_39727001_1 - 1.5e-28 99.3 0.5 3e-28 98.3 0.5 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001013009.3_39727001_1 - 1.2e-06 28.4 0.4 0.0035 17.2 0.0 4.3 4 0 0 4 4 4 2 Cadherin-like He_PIG PF05345.10 001013009.3_39727001_1 - 0.099 12.7 0.0 64 3.7 0.0 4.1 4 0 0 4 4 4 0 Putative Ig domain WD40 PF00400.30 013531.5_32929001_3 - 5.5e-37 125.0 22.9 4.6e-06 27.1 0.1 8.0 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 013531.5_32929001_3 - 2.5e-09 37.2 0.0 0.011 15.9 0.0 5.0 1 1 5 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain TIMELESS_C PF05029.11 003920.4_26229001_2 - 7.1e-188 626.2 14.2 7.1e-188 626.2 14.2 1.8 2 0 0 2 2 2 1 Timeless protein C terminal region TIMELESS PF04821.12 003920.4_26229001_2 - 6.8e-76 254.9 0.7 1.3e-75 254.0 0.7 1.5 1 0 0 1 1 1 1 Timeless protein HTH_32 PF13565.4 003920.4_26229001_2 - 0.076 13.5 0.1 0.076 13.5 0.1 3.4 3 1 0 3 3 3 0 Homeodomain-like domain Myc_N PF01056.16 003920.4_26229001_2 - 0.73 9.5 7.7 0.038 13.7 0.8 2.2 2 0 0 2 2 2 0 Myc amino-terminal region Myb_DNA-binding PF00249.29 003920.4_26229001_2 - 2.7 8.1 7.9 4.4 7.4 0.2 4.8 5 1 0 5 5 5 0 Myb-like DNA-binding domain DED PF01335.19 011063.3_32926001_1 - 4.2e-19 68.5 0.4 1e-18 67.2 0.2 1.8 2 0 0 2 2 2 1 Death effector domain MHC_I PF00129.16 001009058.3_39723001_2 - 2.6e-93 310.4 0.5 3.7e-93 309.9 0.5 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001009058.3_39723001_2 - 8e-17 61.4 0.0 1.8e-16 60.2 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001009058.3_39723001_2 - 1.1e-16 60.3 8.1 2e-16 59.4 8.1 1.5 1 0 0 1 1 1 1 MHC_I C-terminus C2-set_2 PF08205.10 001009058.3_39723001_2 - 0.00048 20.0 0.1 0.0013 18.6 0.1 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001009058.3_39723001_2 - 0.0075 16.3 0.0 0.023 14.7 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain DUF202 PF02656.13 001009058.3_39723001_2 - 0.041 14.2 0.1 12 6.3 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF202) zf-H2C2_2 PF13465.4 001135626.2_39723001_1 - 5.9e-11 42.2 11.1 2.8e-05 24.2 0.8 4.5 4 0 0 4 4 4 3 Zinc-finger double domain BTB PF00651.29 001135626.2_39723001_1 - 5.9e-10 39.2 0.0 1.2e-08 35.0 0.0 2.1 1 1 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.24 001135626.2_39723001_1 - 4.6e-09 36.1 16.7 0.0059 16.9 2.4 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001135626.2_39723001_1 - 5.9e-09 35.9 15.3 0.022 15.4 0.3 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.5 001135626.2_39723001_1 - 2.2e-05 24.5 11.0 0.0022 18.2 0.4 3.6 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.6 001135626.2_39723001_1 - 0.0035 17.5 4.9 1.1 9.5 0.0 3.4 3 1 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.4 001135626.2_39723001_1 - 0.058 13.2 14.5 0.19 11.6 0.3 3.6 3 1 0 3 3 3 0 C2H2-type zinc finger zf-C2HE PF16278.3 001135626.2_39723001_1 - 0.091 13.1 5.8 1.2 9.5 0.5 3.5 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_2 PF12756.5 001135626.2_39723001_1 - 0.091 13.0 8.1 5.3 7.3 0.1 3.2 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) C1_2 PF03107.14 001135626.2_39723001_1 - 3.4 7.9 7.3 12 6.1 2.7 2.9 1 1 1 2 2 2 0 C1 domain Transferrin PF00405.15 214362.3_49829001_2 - 1e-248 823.5 7.9 4.1e-163 542.1 0.0 2.1 2 0 0 2 2 2 2 Transferrin Phosphonate-bd PF12974.5 214362.3_49829001_2 - 2.6e-07 30.3 0.0 0.0046 16.4 0.0 2.8 3 1 0 3 3 3 2 ABC transporter, phosphonate, periplasmic substrate-binding protein ITI_HC_C PF06668.10 213924.2_49826001_3 - 6.7e-67 224.7 0.0 1.3e-66 223.8 0.0 1.5 1 0 0 1 1 1 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus VIT PF08487.8 213924.2_49826001_3 - 1.2e-26 93.0 1.1 1.2e-26 93.0 1.1 1.9 2 0 0 2 2 2 1 Vault protein inter-alpha-trypsin domain VWA PF00092.26 213924.2_49826001_3 - 2e-22 80.1 0.0 3.6e-22 79.3 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.4 213924.2_49826001_3 - 1.3e-17 64.0 0.0 2.3e-17 63.2 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.4 213924.2_49826001_3 - 1.5e-10 41.6 0.0 3.2e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain SRP14 PF02290.13 213924.2_49826001_3 - 0.03 14.6 0.2 1.2 9.4 0.1 2.6 2 0 0 2 2 2 0 Signal recognition particle 14kD protein Ig_3 PF13927.4 001082374.2_37923001_2 - 1.7e-12 47.6 0.7 4.3e-09 36.7 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.4 001082374.2_37923001_2 - 5.3e-07 29.8 0.1 0.0034 17.6 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 001082374.2_37923001_2 - 1.2e-06 28.4 0.5 1.4e-05 24.9 0.0 2.3 2 1 0 2 2 2 1 Immunoglobulin I-set domain V-set PF07686.15 001082374.2_37923001_2 - 7.4e-05 22.7 1.1 0.19 11.8 0.2 3.0 2 1 0 2 2 2 2 Immunoglobulin V-set domain Ig_5 PF16681.3 001082374.2_37923001_2 - 0.017 15.4 0.1 13 6.2 0.0 2.8 2 1 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain ig PF00047.23 001082374.2_37923001_2 - 0.12 12.4 2.6 2.1 8.4 0.2 2.7 2 1 0 2 2 2 0 Immunoglobulin domain PAX PF00292.16 001040417.2_29624001_2 - 2.6e-71 237.2 0.2 4.2e-71 236.6 0.2 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.4 001040417.2_29624001_2 - 3.2e-06 26.6 0.0 7.4e-06 25.5 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_32 PF13565.4 001040417.2_29624001_2 - 2.5e-05 24.7 0.0 0.0004 20.8 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.4 001040417.2_29624001_2 - 0.017 15.0 0.0 0.031 14.2 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix HTH_28 PF13518.4 001040417.2_29624001_2 - 0.1 12.6 0.1 0.28 11.2 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain Cadherin PF00028.15 001013410.3_39728001_1 - 2.1e-80 265.2 0.0 1.7e-15 57.1 0.0 6.2 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001013410.3_39728001_1 - 8.5e-38 127.9 0.1 1.8e-33 114.1 0.1 3.5 4 0 0 4 4 4 2 Cadherin-like Cadherin_C_2 PF16492.3 001013410.3_39728001_1 - 2.5e-28 98.6 0.3 5.1e-28 97.5 0.3 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001013410.3_39728001_1 - 1.6e-08 34.4 1.4 0.0081 16.0 0.0 4.6 4 0 0 4 4 4 3 Cadherin-like FOXP-CC PF16159.3 001009020.3_39725001_1 - 3.8e-35 120.2 4.2 3.8e-35 120.2 4.2 4.7 2 1 2 4 4 4 1 FOXP coiled-coil domain Forkhead PF00250.16 001009020.3_39725001_1 - 3.2e-28 97.7 0.2 1.2e-27 95.9 0.2 2.0 1 0 0 1 1 1 1 Forkhead domain CobT PF06213.10 001009020.3_39725001_1 - 0.24 10.6 34.3 0.43 9.8 34.3 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Plasmodium_Vir PF05795.9 001009020.3_39725001_1 - 0.49 9.6 11.7 1 8.5 9.7 2.2 2 0 0 2 2 2 0 Plasmodium vivax Vir protein DUF4746 PF15928.3 001009020.3_39725001_1 - 0.72 9.1 15.0 1.5 8.0 15.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RR_TM4-6 PF06459.10 001009020.3_39725001_1 - 0.86 9.2 26.6 2 8.1 26.6 1.7 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ALMT PF11744.6 001009020.3_39725001_1 - 2.4 6.8 30.3 5.7 5.5 30.3 1.7 1 0 0 1 1 1 0 Aluminium activated malate transporter SpoIIP PF07454.9 001009020.3_39725001_1 - 6.7 5.9 25.4 13 5.0 25.4 1.5 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Apt1 PF10351.7 001009020.3_39725001_2 - 0.24 10.1 20.1 0.32 9.7 20.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF1510 PF07423.9 001009020.3_39725001_2 - 2.8 7.2 9.3 3.9 6.7 9.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Cadherin PF00028.15 001082582.2_39729001_3 - 4.3e-65 216.1 0.0 1.5e-12 47.7 0.0 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_tail PF15974.3 001082582.2_39729001_3 - 2.2e-63 212.4 4.7 3.6e-63 211.7 4.7 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.10 001082582.2_39729001_3 - 8.5e-28 95.9 0.0 4.9e-26 90.2 0.0 3.5 4 0 0 4 4 4 1 Cadherin-like Cadherin_C_2 PF16492.3 001082582.2_39729001_3 - 2.2e-09 37.8 1.1 6.4e-09 36.3 1.1 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin PF00028.15 001082568.2_39729001_2 - 7.9e-79 260.1 0.0 1.5e-16 60.5 0.1 6.3 5 1 1 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001082568.2_39729001_2 - 1.5e-34 117.5 0.5 3.5e-32 109.9 0.0 4.1 6 0 0 6 6 6 1 Cadherin-like Cadherin_C_2 PF16492.3 001082568.2_39729001_2 - 4.1e-26 91.4 0.2 9.6e-26 90.3 0.2 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_tail PF15974.3 001082568.2_39729001_2 - 2e-25 89.5 3.3 4.1e-25 88.5 3.3 1.4 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_3 PF16184.3 001082568.2_39729001_2 - 1.8e-05 24.5 0.7 1.3 8.9 0.0 4.3 4 0 0 4 4 4 3 Cadherin-like MHC_I PF00129.16 001012439.3_39723001_1 - 2e-93 310.8 0.6 2.7e-93 310.4 0.6 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001012439.3_39723001_1 - 2.3e-17 63.1 0.0 4.9e-17 62.0 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001012439.3_39723001_1 - 5.5e-14 51.7 8.3 9.5e-14 50.9 8.3 1.4 1 0 0 1 1 1 1 MHC_I C-terminus C2-set_2 PF08205.10 001012439.3_39723001_1 - 0.00082 19.3 0.2 0.0021 17.9 0.2 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain TetR_C_6 PF13977.4 001012439.3_39723001_1 - 0.0082 16.2 0.6 0.015 15.3 0.6 1.4 1 0 0 1 1 1 1 Bacterial transcriptional repressor ig PF00047.23 001012439.3_39723001_1 - 0.011 15.8 0.5 0.021 14.9 0.1 1.7 2 0 0 2 2 2 0 Immunoglobulin domain DUF1517 PF07466.9 001012439.3_39723001_1 - 0.17 10.9 0.1 0.29 10.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) wnt PF00110.17 001133626.2_43525001_1 - 6.3e-120 400.2 22.6 7.6e-120 399.9 22.6 1.1 1 0 0 1 1 1 1 wnt family Synuclein PF01387.15 001009158.3_39722001_2 - 3e-53 179.5 17.6 3.6e-53 179.2 17.6 1.1 1 0 0 1 1 1 1 Synuclein CH PF00307.29 001346299.1_26229001_3 - 2e-23 82.5 0.0 4.8e-23 81.3 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.6 001346299.1_26229001_3 - 9.4e-13 47.7 0.0 2e-12 46.6 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain LIM PF00412.20 001346299.1_26229001_3 - 2.3e-07 30.8 13.1 5.4e-07 29.6 13.1 1.7 1 0 0 1 1 1 1 LIM domain FAD_binding_3 PF01494.17 001346299.1_26229001_3 - 5.4e-07 29.1 0.0 2.4e-06 27.0 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.12 001346299.1_26229001_3 - 1.2e-05 24.6 0.0 3.8e-05 23.0 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 001346299.1_26229001_3 - 5.6e-05 22.4 0.0 0.0001 21.6 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 001346299.1_26229001_3 - 5.7e-05 22.2 0.0 8.3e-05 21.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_7 PF13241.4 001346299.1_26229001_3 - 0.0002 21.6 0.0 0.00049 20.4 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding Pyr_redox PF00070.25 001346299.1_26229001_3 - 0.00076 19.9 0.1 0.002 18.5 0.1 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.22 001346299.1_26229001_3 - 0.00096 18.7 0.0 0.0017 17.9 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.12 001346299.1_26229001_3 - 0.0016 17.0 0.0 0.0026 16.4 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.4 001346299.1_26229001_3 - 0.002 18.2 0.1 0.0043 17.1 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.5 001346299.1_26229001_3 - 0.011 14.9 0.2 0.024 13.9 0.1 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.10 001346299.1_26229001_3 - 0.022 13.7 0.0 0.038 12.9 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.15 001346299.1_26229001_3 - 0.041 13.0 0.0 0.078 12.1 0.0 1.3 1 0 0 1 1 1 0 Thi4 family AlaDh_PNT_C PF01262.19 001346299.1_26229001_3 - 0.21 10.7 0.0 0.39 9.9 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain PRY PF13765.4 001044376.1_39724001_1 - 1.8e-14 52.9 0.0 6e-14 51.3 0.0 1.9 2 0 0 2 2 2 1 SPRY-associated domain SPRY PF00622.26 001044376.1_39724001_1 - 7.5e-14 51.8 0.1 6.1e-13 48.8 0.1 2.3 1 1 0 1 1 1 1 SPRY domain zf-C3HC4_4 PF15227.4 001044376.1_39724001_1 - 4.3e-11 42.6 7.6 4.3e-11 42.6 7.6 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 001044376.1_39724001_1 - 1.1e-09 37.8 5.6 1.1e-09 37.8 5.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.23 001044376.1_39724001_1 - 7.7e-09 35.2 5.1 7.7e-09 35.2 5.1 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001044376.1_39724001_1 - 9.6e-09 34.8 6.6 2.2e-08 33.7 6.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.22 001044376.1_39724001_1 - 1.1e-08 35.0 3.4 1.1e-08 35.0 3.4 3.2 3 0 0 3 3 3 1 B-box zinc finger zf-RING_UBOX PF13445.4 001044376.1_39724001_1 - 1.4e-08 34.5 7.7 3.1e-08 33.4 3.1 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.4 001044376.1_39724001_1 - 1.9e-07 31.1 7.5 1.9e-07 31.1 7.5 2.0 2 0 0 2 2 2 1 Ring finger domain zf-RING_6 PF14835.4 001044376.1_39724001_1 - 1.3e-06 28.1 3.3 2.2e-06 27.3 3.3 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.4 001044376.1_39724001_1 - 4e-06 26.6 5.4 4e-06 26.6 5.4 2.4 2 1 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.4 001044376.1_39724001_1 - 5.4e-05 22.8 7.0 5.4e-05 22.8 7.0 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 Baculo_IE-1 PF05290.9 001044376.1_39724001_1 - 0.0012 18.7 1.8 0.003 17.4 1.8 1.6 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-RING_10 PF16685.3 001044376.1_39724001_1 - 0.0024 17.8 4.0 0.0024 17.8 4.0 2.4 2 0 0 2 2 2 1 zinc RING finger of MSL2 Na_trans_assoc PF06512.11 001044376.1_39724001_1 - 0.0025 18.1 0.0 0.0039 17.4 0.0 1.4 1 1 0 1 1 1 1 Sodium ion transport-associated Nop14 PF04147.10 001044376.1_39724001_1 - 0.0039 15.4 7.5 0.0055 14.9 7.5 1.2 1 0 0 1 1 1 1 Nop14-like family zf-RING_4 PF14570.4 001044376.1_39724001_1 - 0.015 14.9 2.2 0.015 14.9 2.2 2.1 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain Rtf2 PF04641.10 001044376.1_39724001_1 - 0.019 14.2 0.6 0.019 14.2 0.6 2.1 2 0 0 2 2 2 0 Rtf2 RING-finger IFT57 PF10498.7 001044376.1_39724001_1 - 0.14 11.0 16.0 0.24 10.2 1.0 2.2 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 CDC45 PF02724.12 001044376.1_39724001_1 - 0.51 8.4 8.4 0.031 12.4 2.4 1.8 2 0 0 2 2 2 0 CDC45-like protein zf-RING_11 PF17123.3 001044376.1_39724001_1 - 0.95 9.1 3.7 2.6 7.7 3.7 1.8 1 0 0 1 1 1 0 RING-like zinc finger zf-Nse PF11789.6 001044376.1_39724001_1 - 1.2 8.9 4.5 3.6 7.3 3.8 2.0 1 1 1 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit Myc_N PF01056.16 001044376.1_39724001_1 - 1.3 8.7 9.6 4.2 7.0 3.4 2.2 2 0 0 2 2 2 0 Myc amino-terminal region RRN3 PF05327.9 001044376.1_39724001_1 - 2.2 6.6 6.8 3.3 6.0 6.8 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 zf-rbx1 PF12678.5 001044376.1_39724001_1 - 6.6 7.0 7.6 0.8 9.9 2.3 2.2 2 0 0 2 2 2 0 RING-H2 zinc finger domain PRY PF13765.4 001123209.1_49824001_1 - 2.4e-14 52.5 0.0 7.4e-14 51.0 0.0 1.9 2 0 0 2 2 2 1 SPRY-associated domain SPRY PF00622.26 001123209.1_49824001_1 - 3.4e-14 52.9 0.1 3.4e-13 49.6 0.0 2.3 1 1 1 2 2 2 1 SPRY domain zf-C3HC4_4 PF15227.4 001123209.1_49824001_1 - 4.7e-11 42.5 7.7 4.7e-11 42.5 7.7 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.4 001123209.1_49824001_1 - 8.6e-10 38.2 5.2 8.6e-10 38.2 5.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001123209.1_49824001_1 - 4.9e-09 35.9 7.5 5.3e-09 35.8 3.8 2.6 1 1 1 2 2 2 1 RING-type zinc-finger zf-B_box PF00643.22 001123209.1_49824001_1 - 1.7e-08 34.4 3.5 1.7e-08 34.4 3.5 3.3 3 0 0 3 3 3 1 B-box zinc finger zf-C3HC4 PF00097.23 001123209.1_49824001_1 - 1.7e-08 34.0 5.3 1.7e-08 34.0 5.3 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001123209.1_49824001_1 - 2.8e-08 33.3 7.3 6.1e-08 32.2 7.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 001123209.1_49824001_1 - 7.3e-07 28.8 3.0 1.2e-06 28.1 3.0 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_2 PF13639.4 001123209.1_49824001_1 - 7.4e-07 29.2 7.8 7.4e-07 29.2 7.8 2.0 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.4 001123209.1_49824001_1 - 1.2e-05 25.0 6.0 1.2e-05 25.0 6.0 2.3 2 1 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.4 001123209.1_49824001_1 - 8e-05 22.3 7.2 8e-05 22.3 7.2 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 Baculo_IE-1 PF05290.9 001123209.1_49824001_1 - 0.0055 16.5 1.6 0.013 15.3 1.6 1.6 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) Na_trans_assoc PF06512.11 001123209.1_49824001_1 - 0.0075 16.5 1.0 0.013 15.7 1.0 1.3 1 0 0 1 1 1 1 Sodium ion transport-associated zf-RING_10 PF16685.3 001123209.1_49824001_1 - 0.0078 16.2 3.8 0.0078 16.2 3.8 2.3 2 0 0 2 2 2 1 zinc RING finger of MSL2 zf-RING_4 PF14570.4 001123209.1_49824001_1 - 0.0088 15.6 1.8 0.0088 15.6 1.8 2.0 2 1 0 2 2 2 1 RING/Ubox like zinc-binding domain Rtf2 PF04641.10 001123209.1_49824001_1 - 0.015 14.5 0.7 0.036 13.3 0.1 1.8 2 0 0 2 2 2 0 Rtf2 RING-finger IFT57 PF10498.7 001123209.1_49824001_1 - 0.094 11.5 12.2 0.12 11.2 1.4 2.2 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Myc_N PF01056.16 001123209.1_49824001_1 - 1.2 8.8 9.1 3.4 7.3 2.7 2.2 2 0 0 2 2 2 0 Myc amino-terminal region zf-C4H2 PF10146.7 001123209.1_49824001_1 - 2.7 8.1 8.3 0.89 9.7 1.2 2.6 2 0 0 2 2 2 0 Zinc finger-containing protein CDC45 PF02724.12 001123209.1_49824001_1 - 8.9 4.3 7.7 0.58 8.3 1.2 1.9 2 0 0 2 2 2 0 CDC45-like protein Mesd PF10185.7 001134102.1_43527001_1 - 8.8e-80 266.0 0.6 1.4e-79 265.3 0.6 1.2 1 0 0 1 1 1 1 Chaperone for wingless signalling and trafficking of LDL receptor DUF1211 PF06736.9 001075613.1_06526001_2 - 6.3e-37 125.8 6.2 9.8e-23 80.3 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF1211) DUF1129 PF06570.9 001075613.1_06526001_2 - 8.3 5.7 6.3 0.75 9.1 0.1 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1129) Kdo PF06293.12 033550.3_26227001_2 - 2e-12 46.8 0.0 3e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.23 033550.3_26227001_2 - 3.6e-08 33.0 0.0 5e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.20 033550.3_26227001_2 - 8.6e-07 28.6 0.0 1.3e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Pkinase_Tyr PF07714.15 033550.3_26227001_2 - 0.0002 20.6 0.0 0.00031 20.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 033550.3_26227001_2 - 0.0012 18.7 6.0 0.31 10.8 0.0 2.9 2 1 1 3 3 3 2 Phosphotransferase enzyme family HIG_1_N PF04588.11 001357840.1_32924001_3 - 3.8e-17 62.2 1.1 7.7e-17 61.2 1.1 1.6 1 0 0 1 1 1 1 Hypoxia induced protein conserved region T4_deiodinase PF00837.15 021653.4_45725001_2 - 1.3e-96 322.3 0.0 1.7e-96 321.9 0.0 1.1 1 0 0 1 1 1 1 Iodothyronine deiodinase LRR_4 PF12799.5 153777.2_32925001_1 - 4.2e-11 42.7 8.1 4.2e-06 26.8 0.1 4.0 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 153777.2_32925001_1 - 7e-07 28.8 9.3 0.00018 21.1 1.8 3.1 1 1 2 3 3 3 3 Leucine rich repeat LRR_9 PF14580.4 153777.2_32925001_1 - 0.00086 18.7 0.3 0.0031 16.9 0.1 2.0 1 1 1 2 2 2 1 Leucine-rich repeat LRR_1 PF00560.31 153777.2_32925001_1 - 0.0052 16.9 3.0 5.2 7.8 0.3 4.3 3 0 0 3 3 3 1 Leucine Rich Repeat LRR_6 PF13516.4 153777.2_32925001_1 - 0.055 13.4 2.9 9.6 6.4 0.0 3.4 3 0 0 3 3 3 0 Leucine Rich repeat SPRY PF00622.26 001163750.1_32924001_1 - 1.2e-18 67.3 0.1 3.2e-18 65.9 0.1 1.7 2 0 0 2 2 2 1 SPRY domain SOCS_box PF07525.14 001163750.1_32924001_1 - 0.0029 17.8 1.3 0.0067 16.6 1.3 1.6 1 0 0 1 1 1 1 SOCS box PRY PF13765.4 178281.1_32927001_1 - 2.2e-21 75.1 1.8 2.4e-21 75.0 0.5 1.8 2 0 0 2 2 2 1 SPRY-associated domain SPRY PF00622.26 178281.1_32927001_1 - 1e-20 73.9 0.0 2.2e-20 72.9 0.0 1.5 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_4 PF15227.4 178281.1_32927001_1 - 8.6e-15 54.5 8.4 8.6e-15 54.5 8.4 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 178281.1_32927001_1 - 3.6e-12 45.8 6.5 3.6e-12 45.8 6.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 178281.1_32927001_1 - 9.3e-11 41.3 7.1 2.7e-10 39.8 7.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 178281.1_32927001_1 - 4.3e-10 39.3 5.9 1.4e-09 37.7 5.9 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.4 178281.1_32927001_1 - 3.9e-09 36.1 5.4 3.9e-09 36.1 5.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 178281.1_32927001_1 - 3.2e-08 33.6 8.7 3.2e-08 33.6 8.7 2.4 3 0 0 3 3 1 1 Ring finger domain zf-B_box PF00643.22 178281.1_32927001_1 - 1.4e-07 31.5 4.4 1.4e-07 31.5 4.4 2.6 2 0 0 2 2 2 1 B-box zinc finger zf-RING_5 PF14634.4 178281.1_32927001_1 - 8.1e-07 28.8 5.4 8.1e-07 28.8 5.4 2.7 3 0 0 3 3 2 1 zinc-RING finger domain zf-RING_6 PF14835.4 178281.1_32927001_1 - 1.7e-06 27.7 1.8 3.7e-06 26.6 1.8 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.4 178281.1_32927001_1 - 1e-05 25.1 5.6 3.3e-05 23.5 5.6 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.5 178281.1_32927001_1 - 8.5e-05 22.6 4.5 8.5e-05 22.6 4.5 2.1 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_10 PF16685.3 178281.1_32927001_1 - 0.00024 21.0 2.9 0.00024 21.0 2.9 2.1 2 0 0 2 2 1 1 zinc RING finger of MSL2 zf-ANAPC11 PF12861.5 178281.1_32927001_1 - 0.0015 18.4 0.9 0.0015 18.4 0.9 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Exonuc_VII_L PF02601.13 178281.1_32927001_1 - 0.019 14.4 3.8 0.029 13.8 3.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit U-box PF04564.13 178281.1_32927001_1 - 0.037 14.1 0.0 0.085 12.9 0.0 1.5 1 0 0 1 1 1 0 U-box domain Fmp27_WPPW PF10359.7 178281.1_32927001_1 - 0.075 11.7 7.4 0.11 11.2 7.4 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Apolipoprotein PF01442.16 178281.1_32927001_1 - 0.2 11.4 13.1 2.9 7.7 11.1 2.0 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Baculo_IE-1 PF05290.9 178281.1_32927001_1 - 0.34 10.7 6.5 0.11 12.3 2.0 2.2 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) DUF2408 PF10303.7 178281.1_32927001_1 - 0.44 11.0 9.7 1.2 9.6 9.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) DUF342 PF03961.11 178281.1_32927001_1 - 1.3 7.4 4.2 2 6.8 4.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) zf-C3HC4_5 PF17121.3 178281.1_32927001_1 - 1.3 8.8 4.7 4.3 7.2 4.0 2.1 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) AAA_9 PF12781.5 178281.1_32927001_1 - 1.6 7.6 5.3 3 6.8 5.3 1.3 1 0 0 1 1 1 0 ATP-binding dynein motor region D5 zf-RING_11 PF17123.3 178281.1_32927001_1 - 1.8 8.2 6.2 6.4 6.5 6.2 2.1 1 0 0 1 1 1 0 RING-like zinc finger OmpH PF03938.12 178281.1_32927001_1 - 5.5 6.8 8.6 11 5.8 8.6 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) MRP-L28 PF09812.7 178281.1_32927001_1 - 7.3 6.6 8.8 15 5.5 8.8 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 HAP1_N PF04849.11 001357973.1_32925001_3 - 1.7e-81 273.7 11.2 2.2e-81 273.3 11.2 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region KASH_CCD PF14662.4 001357973.1_32925001_3 - 0.018 14.7 12.4 0.029 14.1 12.4 1.3 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH bZIP_2 PF07716.13 001357973.1_32925001_3 - 0.023 14.7 7.8 0.86 9.6 0.1 2.6 2 0 0 2 2 2 0 Basic region leucine zipper bZIP_1 PF00170.19 001357973.1_32925001_3 - 0.023 14.6 7.7 1.3 9.1 3.0 2.3 2 0 0 2 2 2 0 bZIP transcription factor ZapB PF06005.10 001357973.1_32925001_3 - 0.46 10.8 9.3 4.1 7.8 6.6 2.3 2 0 0 2 2 2 0 Cell division protein ZapB DUF745 PF05335.11 001357973.1_32925001_3 - 0.61 9.7 2.0 0.99 9.0 2.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Phlebovirus_NSM PF07246.9 001357973.1_32925001_3 - 0.67 9.2 3.0 0.33 10.2 0.9 1.4 2 0 0 2 2 2 0 Phlebovirus nonstructural protein NS-M Rootletin PF15035.4 001357973.1_32925001_3 - 0.71 9.8 14.1 0.26 11.2 8.2 2.1 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Med9 PF07544.11 001357973.1_32925001_3 - 0.83 9.6 4.4 0.43 10.6 1.6 1.9 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 GIT_CC PF16559.3 001357973.1_32925001_3 - 0.96 9.4 6.9 6.4 6.8 0.1 2.3 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor PRKG1_interact PF15898.3 001357973.1_32925001_3 - 1.1 10.0 8.6 1.2 10.0 7.6 1.5 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain RasGAP_C PF03836.13 001357973.1_32925001_3 - 1.9 8.5 6.7 13 5.8 6.5 2.2 1 1 0 1 1 1 0 RasGAP C-terminus DUF972 PF06156.11 001357973.1_32925001_3 - 2.7 8.6 7.2 43 4.7 4.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF972) TSC22 PF01166.16 001357973.1_32925001_3 - 3.4 7.9 6.9 4.5 7.5 0.1 2.7 2 1 0 2 2 2 0 TSC-22/dip/bun family Fmp27_WPPW PF10359.7 001357973.1_32925001_3 - 6.8 5.3 7.1 9.6 4.8 7.1 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DivIVA PF05103.11 001357973.1_32925001_3 - 7.6 6.5 7.4 15 5.6 5.6 2.2 1 1 1 2 2 2 0 DivIVA protein SNARE PF05739.17 037942.1_26229120_3 - 3.9e-19 68.3 3.1 6.4e-19 67.6 3.1 1.4 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.23 037942.1_26229120_3 - 0.0079 15.8 0.5 0.012 15.2 0.5 1.2 1 0 0 1 1 1 1 Syntaxin Synaptobrevin PF00957.19 037942.1_26229120_3 - 0.18 11.5 2.7 0.33 10.6 2.7 1.4 1 0 0 1 1 1 0 Synaptobrevin DENN PF02141.19 152151.1_32929120_1 - 2.4e-50 170.9 3.4 5e-50 169.9 3.4 1.6 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.17 152151.1_32929120_1 - 1.6e-05 24.6 1.0 3.8e-05 23.5 1.0 1.6 1 0 0 1 1 1 1 dDENN domain uDENN PF03456.16 152151.1_32929120_1 - 0.00057 20.5 0.0 0.002 18.8 0.0 1.9 1 0 0 1 1 1 1 uDENN domain Avl9 PF09794.7 152151.1_32929120_1 - 0.0072 14.9 0.0 0.024 13.2 0.0 1.7 1 1 1 2 2 2 1 Transport protein Avl9 DUF4401 PF14351.4 152151.1_32929120_1 - 3.3 6.8 7.0 0.12 11.6 1.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4401) SUIM_assoc PF16619.3 028412.1_26222120_1 - 0.42 10.6 3.3 0.69 9.9 3.3 1.3 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 ApoC-I PF04691.10 028412.1_26222120_2 - 2.5e-23 81.6 0.3 3.6e-23 81.1 0.3 1.2 1 0 0 1 1 1 1 Apolipoprotein C-I (ApoC-1) HAP1_N PF04849.11 152160.1_32929120_1 - 3.9e-135 449.9 39.1 5e-135 449.5 39.1 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Milton PF12448.6 152160.1_32929120_1 - 6.5e-68 228.1 6.1 1.5e-67 227.0 6.1 1.6 1 0 0 1 1 1 1 Kinesin associated protein KASH_CCD PF14662.4 152160.1_32929120_1 - 0.026 14.3 40.0 0.059 13.1 14.0 3.2 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH Atg14 PF10186.7 152160.1_32929120_1 - 1.5 7.7 23.2 3.7 6.4 4.1 2.5 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1664 PF07889.10 152160.1_32929120_1 - 3 7.7 15.2 0.43 10.4 0.8 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) ATG16 PF08614.9 152160.1_32929120_1 - 3.3 7.7 36.1 1.7 8.7 21.1 2.6 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) MCPsignal PF00015.19 152160.1_32929120_1 - 4.2 6.9 9.5 15 5.1 5.9 2.2 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Rootletin PF15035.4 152160.1_32929120_1 - 5.3 6.9 38.3 0.68 9.9 7.9 3.1 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion ZapB PF06005.10 152160.1_32929120_1 - 5.5 7.4 39.1 2.9 8.3 4.6 3.8 2 1 0 3 3 3 0 Cell division protein ZapB KELK PF15796.3 152160.1_32929120_1 - 6.9 7.1 31.8 0.072 13.5 7.4 3.5 2 1 1 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase TMF_TATA_bd PF12325.6 152160.1_32929120_1 - 8.9 6.4 34.8 0.22 11.6 17.9 3.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding CorA PF01544.16 152160.1_32929120_1 - 9.7 5.3 16.6 0.5 9.5 7.9 2.3 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Annexin PF00191.18 007193.4_26223001_3 - 9.7e-82 268.9 7.8 5.3e-22 77.5 0.0 4.1 4 0 0 4 4 4 4 Annexin ASC PF00858.22 017046.1_45726001_3 - 6e-98 328.3 16.9 7.3e-98 328.0 16.9 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel CCB1 PF12046.6 017046.1_45726001_3 - 0.091 12.0 0.7 1.9 7.7 0.0 2.2 2 0 0 2 2 2 0 Cofactor assembly of complex C subunit B Acyl_transf_1 PF00698.19 017332.1_45729001_1 - 3.1e-112 375.1 0.0 5.4e-112 374.3 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain ketoacyl-synt PF00109.24 017332.1_45729001_1 - 1.4e-71 240.9 0.0 2.6e-71 240.0 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thioesterase PF00975.18 017332.1_45729001_1 - 8.8e-58 196.0 0.0 2.9e-57 194.3 0.0 2.0 1 0 0 1 1 1 1 Thioesterase domain KR PF08659.8 017332.1_45729001_1 - 3.6e-48 163.7 0.0 8.5e-48 162.5 0.0 1.7 1 0 0 1 1 1 1 KR domain KAsynt_C_assoc PF16197.3 017332.1_45729001_1 - 1e-36 125.6 0.1 2.8e-36 124.3 0.0 1.8 2 0 0 2 2 1 1 Ketoacyl-synthetase C-terminal extension Ketoacyl-synt_C PF02801.20 017332.1_45729001_1 - 9.8e-36 122.2 0.0 1.9e-35 121.3 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N PF00107.24 017332.1_45729001_1 - 1.4e-19 70.1 0.0 4.1e-19 68.6 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PS-DH PF14765.4 017332.1_45729001_1 - 2.1e-17 63.2 0.0 4.7e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase ADH_zinc_N_2 PF13602.4 017332.1_45729001_1 - 2.4e-15 57.6 0.1 1.1e-14 55.4 0.0 2.2 2 0 0 2 2 1 1 Zinc-binding dehydrogenase Methyltransf_12 PF08242.10 017332.1_45729001_1 - 7.8e-10 39.2 0.0 8.7e-09 35.9 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain PP-binding PF00550.23 017332.1_45729001_1 - 3e-08 33.8 0.6 6.3e-08 32.7 0.6 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short PF00106.23 017332.1_45729001_1 - 2.7e-07 30.1 0.0 6.1e-06 25.7 0.0 2.5 2 0 0 2 2 2 1 short chain dehydrogenase Methyltransf_31 PF13847.4 017332.1_45729001_1 - 4e-07 29.8 0.0 2.5e-06 27.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.4 017332.1_45729001_1 - 2.8e-06 27.2 0.0 7.1e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.4 017332.1_45729001_1 - 0.00015 22.2 0.0 0.0019 18.7 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.10 017332.1_45729001_1 - 0.00018 21.9 0.0 0.0011 19.4 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Thiolase_N PF00108.21 017332.1_45729001_1 - 0.00032 20.0 0.0 0.0006 19.1 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain adh_short_C2 PF13561.4 017332.1_45729001_1 - 0.017 14.6 0.0 0.037 13.5 0.0 1.5 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase YjeF_N PF03853.13 017332.1_45729001_1 - 0.033 14.0 0.1 0.81 9.4 0.0 2.5 2 0 0 2 2 2 0 YjeF-related protein N-terminus AlaDh_PNT_C PF01262.19 017332.1_45729001_1 - 0.12 11.5 0.0 2.6 7.1 0.0 2.3 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain ACP_syn_III PF08545.8 017332.1_45729001_1 - 0.17 11.7 0.2 0.42 10.4 0.2 1.7 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III CARD PF00619.19 024110.4_26229001_1 - 2.5e-24 85.0 0.1 3.8e-23 81.2 0.0 2.7 2 0 0 2 2 2 1 Caspase recruitment domain Guanylate_kin PF00625.19 024110.4_26229001_1 - 3.1e-05 23.6 0.0 0.00011 21.9 0.0 1.8 2 0 0 2 2 2 1 Guanylate kinase PDZ PF00595.22 024110.4_26229001_1 - 0.0062 16.7 0.0 0.013 15.7 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Y_phosphatase PF00102.25 024110.4_26229001_1 - 0.12 11.8 1.1 0.21 11.0 1.1 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase LPP PF04728.11 024110.4_26229001_1 - 1.6 9.0 4.0 73 3.7 0.0 3.6 3 0 0 3 3 3 0 Lipoprotein leucine-zipper Cofilin_ADF PF00241.18 007688.2_32926001_3 - 1.4e-28 99.4 1.3 2.2e-28 98.8 1.3 1.2 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein LRR_8 PF13855.4 001099769.2_21027001_2 - 7.8e-48 160.0 51.2 1.2e-11 44.1 0.4 10.8 6 2 6 12 12 12 11 Leucine rich repeat TIR PF01582.18 001099769.2_21027001_2 - 4.9e-33 114.2 0.1 9.7e-33 113.3 0.1 1.4 1 0 0 1 1 1 1 TIR domain LRR_4 PF12799.5 001099769.2_21027001_2 - 1.2e-31 108.0 53.9 7.5e-07 29.2 1.5 11.8 4 2 8 14 14 14 11 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001099769.2_21027001_2 - 2.8e-11 43.4 4.7 0.00015 21.6 0.1 4.5 2 2 2 4 4 4 4 Leucine rich repeats (6 copies) LRR_1 PF00560.31 001099769.2_21027001_2 - 1.1e-10 40.2 50.7 1.1 9.8 0.9 15.5 15 2 0 15 15 15 4 Leucine Rich Repeat LRR_9 PF14580.4 001099769.2_21027001_2 - 1.9e-10 40.4 20.8 0.00038 19.9 0.1 5.5 1 1 3 5 5 5 4 Leucine-rich repeat TIR_2 PF13676.4 001099769.2_21027001_2 - 8.7e-09 35.5 0.1 1.5e-08 34.7 0.1 1.4 1 0 0 1 1 1 1 TIR domain LRR_6 PF13516.4 001099769.2_21027001_2 - 1.8e-07 30.5 47.7 0.58 10.2 0.2 13.7 16 0 0 16 16 16 4 Leucine Rich repeat DUF1863 PF08937.9 001099769.2_21027001_2 - 2e-05 24.8 0.4 7.1e-05 23.0 0.4 1.8 1 1 0 1 1 1 1 MTH538 TIR-like domain (DUF1863) Arf PF00025.19 001174150.1_26228001_1 - 2e-40 137.9 0.0 3.6e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.20 001174150.1_26228001_1 - 1.7e-07 30.8 0.0 2.9e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001174150.1_26228001_1 - 3.4e-06 27.2 0.0 6e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.8 001174150.1_26228001_1 - 4.2e-05 22.9 0.0 7.3e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit DUF4414 PF14377.4 001174150.1_26228001_1 - 0.1 12.8 4.5 0.24 11.6 4.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4414) RRM_1 PF00076.20 001314241.1_09024001_1 - 9.6e-14 50.8 0.3 1.4e-13 50.3 0.3 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001314241.1_09024001_1 - 0.0014 18.6 0.2 0.0046 16.9 0.2 1.8 1 1 0 1 1 1 1 RNA recognition motif Trypsin PF00089.24 001168212.2_22424001_1 - 1.1e-60 205.0 0.0 1.7e-60 204.5 0.0 1.2 1 0 0 1 1 1 1 Trypsin Kringle PF00051.16 001168212.2_22424001_1 - 1.8e-22 79.3 4.4 1.8e-22 79.3 4.4 4.0 4 0 0 4 4 4 1 Kringle domain fn2 PF00040.17 001168212.2_22424001_1 - 1.8e-15 56.8 6.9 1.8e-15 56.8 6.9 2.7 2 0 0 2 2 2 1 Fibronectin type II domain EGF PF00008.25 001168212.2_22424001_1 - 1.6e-12 47.4 24.4 9.6e-09 35.3 10.4 4.5 5 0 0 5 5 5 2 EGF-like domain fn1 PF00039.16 001168212.2_22424001_1 - 5.3e-10 39.2 0.7 2.2e-09 37.2 0.7 2.2 1 0 0 1 1 1 1 Fibronectin type I domain Trypsin_2 PF13365.4 001168212.2_22424001_1 - 3e-06 28.0 0.0 7.1e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain EGF_2 PF07974.11 001168212.2_22424001_1 - 5.6e-06 26.5 31.6 0.0011 19.2 9.8 3.7 3 0 0 3 3 3 2 EGF-like domain hEGF PF12661.5 001168212.2_22424001_1 - 0.00013 22.4 15.6 0.0012 19.3 6.5 4.8 5 0 0 5 5 5 2 Human growth factor-like EGF DUF1986 PF09342.9 001168212.2_22424001_1 - 0.082 13.2 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) TRP_2 PF08344.9 001082651.1_37925001_1 - 4.4e-25 87.5 2.2 9.5e-25 86.5 2.2 1.6 1 0 0 1 1 1 1 Transient receptor ion channel II Ion_trans PF00520.29 001082651.1_37925001_1 - 1e-16 60.8 12.9 1.9e-16 59.9 12.9 1.4 1 0 0 1 1 1 1 Ion transport protein Ank_2 PF12796.5 001082651.1_37925001_1 - 1.6e-06 28.5 0.1 5.5e-06 26.7 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.4 001082651.1_37925001_1 - 0.00023 21.5 0.0 0.14 12.7 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.4 001082651.1_37925001_1 - 0.062 13.7 1.1 1.1e+02 3.8 0.0 4.3 4 0 0 4 4 4 0 Ankyrin repeat DUF2157 PF09925.7 001082651.1_37925001_1 - 4.2 7.0 6.2 2.7 7.7 3.7 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) Ig_2 PF13895.4 001271373.1_32924001_2 - 1.1e-06 28.7 0.2 2.3e-06 27.7 0.2 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 001271373.1_32924001_2 - 0.00024 21.5 0.6 0.0006 20.2 0.1 1.9 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001271373.1_32924001_2 - 0.0069 16.4 0.1 0.021 14.9 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.15 001271373.1_32924001_2 - 0.032 14.3 0.6 3.9 7.5 0.1 2.4 1 1 1 2 2 2 0 Immunoglobulin V-set domain Orthopox_A43R PF06517.9 001271373.1_32924001_2 - 0.056 13.1 0.0 6.8 6.3 0.0 2.1 2 0 0 2 2 2 0 Orthopoxvirus A43R protein I-set PF07679.14 001271373.1_32924001_2 - 0.13 12.2 0.0 0.32 11.0 0.0 1.7 1 1 0 1 1 1 0 Immunoglobulin I-set domain Rho_GDI PF02115.15 135637.1_26222120_1 - 3.5e-49 167.0 0.1 4.6e-49 166.7 0.1 1.1 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Metallophos_2 PF12850.5 104100.1_26223120_1 - 2.3e-20 73.3 0.0 3e-20 72.9 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.26 104100.1_26223120_1 - 0.00032 21.1 0.6 0.28 11.5 0.2 2.2 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase DSPc PF00782.18 111939.1_26224120_1 - 4.5e-42 142.9 0.0 6.9e-42 142.3 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.4 111939.1_26224120_1 - 1.2e-05 25.4 0.0 2e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.25 111939.1_26224120_1 - 0.0014 18.1 0.0 0.0023 17.4 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.10 111939.1_26224120_1 - 0.0085 16.2 0.0 0.019 15.1 0.0 1.5 1 0 0 1 1 1 1 Rit1 DUSP-like domain TUDOR PF00567.22 104310.1_32928120_1 - 5e-22 78.1 0.0 8.1e-22 77.4 0.0 1.4 1 0 0 1 1 1 1 Tudor domain KH_1 PF00013.27 104310.1_32928120_1 - 5.5e-11 42.0 0.0 8.9e-11 41.3 0.0 1.3 1 0 0 1 1 1 1 KH domain Agenet PF05641.10 104310.1_32928120_1 - 0.0027 18.0 0.4 0.0056 17.0 0.4 1.5 1 0 0 1 1 1 1 Agenet domain RII_binding_1 PF10522.7 104310.1_32928120_2 - 0.002 18.0 0.6 0.0039 17.0 0.6 1.5 1 0 0 1 1 1 1 RII binding domain Prion PF00377.16 001314247.1_09022001_1 - 4.4e-37 126.4 1.9 5.6e-37 126.0 1.9 1.1 1 0 0 1 1 1 1 Prion/Doppel alpha-helical domain Prion_bPrPp PF11587.6 001314247.1_09022001_1 - 4.6e-19 67.8 1.5 8.7e-19 66.9 1.5 1.5 1 0 0 1 1 1 1 Major prion protein bPrPp - N terminal Peptidase_C1 PF00112.21 017320.1_45723001_1 - 7.3e-78 261.5 2.6 1e-77 261.1 2.6 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 017320.1_45723001_1 - 4.6e-07 30.1 0.1 7.3e-07 29.4 0.1 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 017320.1_45723001_1 - 0.0076 14.9 1.8 0.13 10.9 0.4 2.1 2 0 0 2 2 2 2 Peptidase C1-like family HSCB_C PF07743.11 001318314.1_26222001_1 - 4.3e-07 30.2 0.2 6.4e-07 29.6 0.2 1.2 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.29 001318314.1_26222001_2 - 0.0002 21.3 0.1 0.00029 20.8 0.1 1.2 1 0 0 1 1 1 1 DnaJ domain Pyr_redox_2 PF07992.12 001261445.1_26229001_3 - 1.7e-54 184.9 0.5 2.1e-54 184.6 0.5 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.20 001261445.1_26229001_3 - 3.6e-28 97.9 0.0 7.2e-28 96.9 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.25 001261445.1_26229001_3 - 3.1e-18 66.0 3.1 3.6e-15 56.2 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 001261445.1_26229001_3 - 1.3e-14 54.0 0.7 1.3e-10 40.8 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 001261445.1_26229001_3 - 7.3e-07 28.5 0.6 1.3e-06 27.7 0.3 1.5 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.5 001261445.1_26229001_3 - 0.00018 20.8 0.0 0.00024 20.5 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.12 001261445.1_26229001_3 - 0.00032 19.4 0.4 0.00057 18.5 0.2 1.5 2 0 0 2 2 2 1 HI0933-like protein AlaDh_PNT_C PF01262.19 001261445.1_26229001_3 - 0.00052 19.2 0.2 0.026 13.7 0.0 2.1 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.15 001261445.1_26229001_3 - 0.0023 17.1 0.6 0.0042 16.2 0.0 1.6 2 0 0 2 2 2 1 Thi4 family GIDA PF01134.20 001261445.1_26229001_3 - 0.0027 16.7 0.4 0.0046 16.0 0.4 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.4 001261445.1_26229001_3 - 0.0053 16.8 0.3 0.0053 16.8 0.3 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 001261445.1_26229001_3 - 0.014 14.9 0.8 0.02 14.4 0.2 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.17 001261445.1_26229001_3 - 0.044 12.9 0.1 0.044 12.9 0.1 2.0 2 0 0 2 2 2 0 FAD binding domain NAD_binding_7 PF13241.4 001261445.1_26229001_3 - 0.065 13.5 0.4 6.1 7.2 0.1 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding Fibrinogen_C PF00147.16 001287615.1_31326001_3 - 2.2e-94 315.2 5.0 3e-94 314.8 5.0 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain FlaC_arch PF05377.9 001287615.1_31326001_3 - 0.00024 21.3 0.9 0.0029 17.8 0.2 2.3 2 0 0 2 2 2 1 Flagella accessory protein C (FlaC) Transposase_22 PF02994.12 001287615.1_31326001_3 - 0.0056 15.5 0.3 0.008 14.9 0.3 1.1 1 0 0 1 1 1 1 L1 transposable element Laminin_II PF06009.10 001287615.1_31326001_3 - 0.0081 16.0 3.1 0.0085 16.0 1.0 1.8 2 0 0 2 2 2 1 Laminin Domain II TPR_MLP1_2 PF07926.10 001287615.1_31326001_3 - 0.0084 16.0 0.7 0.013 15.4 0.7 1.2 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein LPP PF04728.11 001287615.1_31326001_3 - 0.026 14.8 3.4 0.32 11.3 0.6 2.4 2 0 0 2 2 2 0 Lipoprotein leucine-zipper LXG PF04740.10 001287615.1_31326001_3 - 0.034 13.7 0.7 0.45 10.1 0.3 2.1 2 0 0 2 2 2 0 LXG domain of WXG superfamily Prefoldin PF02996.15 001287615.1_31326001_3 - 0.096 12.5 0.5 4.2 7.2 0.3 2.2 2 0 0 2 2 2 0 Prefoldin subunit bZIP_1 PF00170.19 001287615.1_31326001_3 - 0.1 12.5 3.6 0.97 9.5 0.3 2.3 2 0 0 2 2 2 0 bZIP transcription factor Cnn_1N PF07989.9 001287615.1_31326001_3 - 0.36 10.8 1.8 6.7 6.8 0.0 2.3 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Med9 PF07544.11 001287615.1_31326001_3 - 0.4 10.7 2.1 1.1 9.3 0.3 2.0 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF4140 PF13600.4 001287615.1_31326001_3 - 0.47 10.8 1.2 1.1 9.6 1.2 1.6 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Tektin PF03148.12 001287615.1_31326001_3 - 0.51 8.9 2.2 2 6.9 0.1 2.0 2 0 0 2 2 2 0 Tektin family NPV_P10 PF05531.10 001287615.1_31326001_3 - 0.51 10.7 4.6 1.3 9.4 1.3 2.5 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein TBPIP PF07106.11 001287615.1_31326001_3 - 0.59 9.7 2.7 1.2 8.8 0.1 2.3 3 0 0 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TNFR_c6 PF00020.16 001081907.1_21024001_2 - 1.6e-21 76.3 48.3 4.2e-10 39.7 3.6 4.5 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region Pyr_redox_2 PF07992.12 182742.2_26229001_3 - 1.6e-54 185.0 0.5 2e-54 184.7 0.5 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.20 182742.2_26229001_3 - 3.5e-28 97.9 0.0 6.7e-28 97.0 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.25 182742.2_26229001_3 - 2.8e-18 66.1 3.1 3.4e-15 56.2 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 182742.2_26229001_3 - 1.1e-14 54.2 0.7 1.3e-10 40.9 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 182742.2_26229001_3 - 6.9e-07 28.5 0.6 1.2e-06 27.7 0.3 1.5 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.5 182742.2_26229001_3 - 0.00017 20.9 0.0 0.00022 20.5 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.12 182742.2_26229001_3 - 0.0003 19.5 0.4 0.00055 18.6 0.2 1.5 2 0 0 2 2 2 1 HI0933-like protein AlaDh_PNT_C PF01262.19 182742.2_26229001_3 - 0.00047 19.4 0.2 0.024 13.8 0.0 2.1 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.15 182742.2_26229001_3 - 0.0021 17.2 0.5 0.0039 16.3 0.0 1.6 2 0 0 2 2 2 1 Thi4 family GIDA PF01134.20 182742.2_26229001_3 - 0.0026 16.8 0.4 0.0043 16.0 0.4 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.4 182742.2_26229001_3 - 0.005 16.9 0.3 0.005 16.9 0.3 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.22 182742.2_26229001_3 - 0.013 15.0 0.9 0.019 14.5 0.2 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.17 182742.2_26229001_3 - 0.041 13.0 0.1 0.041 13.0 0.1 2.0 2 0 0 2 2 2 0 FAD binding domain NAD_binding_7 PF13241.4 182742.2_26229001_3 - 0.058 13.7 0.4 5.8 7.3 0.1 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding p450 PF00067.20 214423.1_49825001_1 - 1.3e-129 432.8 0.2 1.5e-129 432.6 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 Guanylate_cyc PF00211.18 009623.2_32929001_1 - 3e-125 414.7 0.0 2.1e-65 219.7 0.0 2.2 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain AC_N PF16214.3 009623.2_32929001_1 - 2.7e-36 125.5 1.9 2.7e-36 125.5 1.9 2.1 2 0 0 2 2 2 1 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF1053 PF06327.12 009623.2_32929001_1 - 6e-28 97.3 0.1 1.3e-27 96.2 0.1 1.6 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1053) 7tm_1 PF00001.19 031038.3_45726001_1 - 1.6e-38 132.4 13.7 2.5e-38 131.7 13.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Leptin PF02024.13 001009850.1_22426001_3 - 8.7e-69 229.8 0.2 1.1e-68 229.4 0.2 1.1 1 0 0 1 1 1 1 Leptin Ribosomal_L36 PF00444.16 001329978.1_39722001_2 - 3.6e-16 58.9 9.3 3.6e-16 58.9 9.3 2.1 2 0 0 2 2 2 1 Ribosomal protein L36 LRR_6 PF13516.4 146128.1_26224120_2 - 1.4e-20 71.4 29.1 0.00012 21.7 0.0 9.4 10 0 0 10 10 10 6 Leucine Rich repeat LRR_4 PF12799.5 146128.1_26224120_2 - 2.9e-13 49.6 18.7 0.019 15.2 0.2 6.7 5 1 0 6 6 6 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 146128.1_26224120_2 - 0.001 18.7 13.9 0.39 10.4 1.4 5.6 5 2 0 5 5 5 3 Leucine rich repeat LRR_1 PF00560.31 146128.1_26224120_2 - 0.0015 18.6 35.4 1.2 9.8 0.0 10.2 10 2 0 10 10 10 3 Leucine Rich Repeat Clat_adaptor_s PF01217.18 110905.1_26229120_3 - 9e-49 164.9 4.4 9.7e-48 161.6 4.4 2.1 1 1 0 1 1 1 1 Clathrin adaptor complex small chain HlyD_D4 PF16572.3 152173.1_32924120_1 - 0.87 9.4 17.7 6 6.7 1.3 5.3 2 2 3 6 6 6 0 Long alpha hairpin domain of cation efflux system protein, CusB PID PF00640.21 001164764.3_29629001_3 - 1.1e-32 112.8 1.8 1.1e-32 112.8 1.8 2.0 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) Phage_GPO PF05929.9 001164764.3_29629001_3 - 2.6 7.5 8.8 2.3 7.7 7.0 1.6 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase ARPC4 PF05856.10 001169055.2_40424001_3 - 8.1e-83 275.9 8.0 1e-82 275.6 8.0 1.1 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) Sm_like PF16243.3 001169055.2_40424001_3 - 0.016 15.2 0.1 0.028 14.4 0.1 1.3 1 0 0 1 1 1 0 Sm_like domain RIB43A PF05914.10 026357.2_32924001_1 - 3.1e-143 476.9 48.6 3.6e-143 476.7 48.6 1.0 1 0 0 1 1 1 1 RIB43A BESS PF02944.18 026357.2_32924001_2 - 0.19 11.5 0.3 0.32 10.7 0.3 1.4 1 0 0 1 1 1 0 BESS motif DUF3704 PF12488.6 152196.1_32926120_2 - 9.7e-08 31.4 4.9 2.6e-07 30.0 4.9 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3704) Ephrin_rec_like PF07699.11 001358063.1_32929001_1 - 4.9e-07 29.3 62.4 0.003 17.2 6.0 7.7 4 3 3 7 7 7 7 Putative ephrin-receptor like NCD3G PF07562.12 001358063.1_32929001_1 - 0.028 14.3 53.6 0.15 11.9 7.9 6.6 6 0 0 6 6 6 0 Nine Cysteines Domain of family 3 GPCR Arf PF00025.19 152188.1_32924120_1 - 2.3e-23 82.4 0.0 3.3e-23 81.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Arf PF00025.19 152188.1_32924120_2 - 7.5e-26 90.5 0.1 1.1e-25 89.9 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 152188.1_32924120_2 - 6e-10 39.3 0.1 9.7e-10 38.6 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 152188.1_32924120_2 - 4.4e-07 29.5 0.1 6.2e-07 29.0 0.1 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.8 152188.1_32924120_2 - 8e-06 25.3 0.0 1.1e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.18 152188.1_32924120_2 - 0.0014 17.7 0.1 0.45 9.5 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.10 152188.1_32924120_2 - 0.0024 17.1 0.0 0.0033 16.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 152188.1_32924120_2 - 0.01 15.8 0.0 0.015 15.2 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_14 PF13173.4 152188.1_32924120_2 - 0.087 12.7 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain Abhydrolase_2 PF02230.14 008866.3_32926001_2 - 5.4e-88 294.3 0.0 7e-88 293.9 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.11 008866.3_32926001_2 - 6.1e-05 22.8 0.0 0.0004 20.1 0.0 1.9 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.18 008866.3_32926001_2 - 0.00014 21.4 0.2 0.0007 19.2 0.2 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.6 008866.3_32926001_2 - 0.00033 19.9 0.0 0.65 9.1 0.0 2.8 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.5 008866.3_32926001_2 - 0.0021 18.6 0.0 0.0029 18.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Cutinase PF01083.20 008866.3_32926001_2 - 0.0096 15.8 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 1 Cutinase DUF2974 PF11187.6 008866.3_32926001_2 - 0.041 13.3 0.0 0.07 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) FSH1 PF03959.11 008866.3_32926001_2 - 0.087 12.3 0.0 0.23 11.0 0.0 1.6 1 1 0 1 1 1 0 Serine hydrolase (FSH1) DUF4268 PF14088.4 008866.3_32926001_3 - 0.049 13.4 0.0 0.081 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4268) ABC_membrane PF00664.21 133401.1_45729001_2 - 1.6e-168 559.2 41.3 1.5e-94 316.5 10.8 2.5 3 0 0 3 3 2 2 ABC transporter transmembrane region ABC_tran PF00005.25 133401.1_45729001_2 - 2.3e-76 254.7 0.6 1.6e-37 128.9 0.1 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.17 133401.1_45729001_2 - 6.1e-16 58.4 5.3 6.5e-07 28.9 1.1 3.8 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.4 133401.1_45729001_2 - 2.8e-10 40.7 1.7 0.00055 20.2 0.1 2.8 2 1 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.7 133401.1_45729001_2 - 2.8e-09 36.2 2.1 0.00021 20.1 0.0 3.0 4 0 0 4 4 4 2 Predicted ATPase of the ABC class AAA_22 PF13401.4 133401.1_45729001_2 - 9.7e-09 35.5 0.6 0.0043 17.2 0.1 3.1 2 2 0 2 2 2 2 AAA domain DUF258 PF03193.14 133401.1_45729001_2 - 7.4e-08 32.3 0.2 0.0096 15.7 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function, DUF258 G-alpha PF00503.18 133401.1_45729001_2 - 2.6e-07 30.0 0.1 0.0041 16.2 0.0 2.2 2 0 0 2 2 2 2 G-protein alpha subunit Rad17 PF03215.13 133401.1_45729001_2 - 1.2e-06 27.6 0.0 0.0078 15.0 0.0 2.3 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein Zeta_toxin PF06414.10 133401.1_45729001_2 - 1.7e-06 27.3 1.1 0.032 13.4 0.0 3.4 4 0 0 4 4 4 2 Zeta toxin AAA PF00004.27 133401.1_45729001_2 - 3.4e-06 27.4 3.9 0.27 11.5 0.2 4.3 2 2 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.4 133401.1_45729001_2 - 6.6e-06 25.6 0.8 0.097 12.3 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_5 PF07728.12 133401.1_45729001_2 - 1.1e-05 25.3 0.7 0.19 11.6 0.0 3.5 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_15 PF13175.4 133401.1_45729001_2 - 0.00015 21.4 0.1 0.31 10.5 0.0 2.8 3 0 0 3 3 3 2 AAA ATPase domain AAA_30 PF13604.4 133401.1_45729001_2 - 0.00048 19.8 2.0 0.27 10.8 0.1 3.1 2 2 0 2 2 2 1 AAA domain AAA_14 PF13173.4 133401.1_45729001_2 - 0.0006 19.7 0.1 0.2 11.5 0.0 3.5 3 1 0 3 3 3 1 AAA domain APS_kinase PF01583.18 133401.1_45729001_2 - 0.00076 19.3 0.2 0.72 9.6 0.0 2.5 2 0 0 2 2 2 2 Adenylylsulphate kinase AAA_28 PF13521.4 133401.1_45729001_2 - 0.00078 19.6 0.1 4 7.5 0.0 3.5 2 1 1 3 3 3 1 AAA domain SbcCD_C PF13558.4 133401.1_45729001_2 - 0.00081 19.4 3.8 1.2 9.2 0.3 3.7 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit DUF87 PF01935.15 133401.1_45729001_2 - 0.0014 18.5 1.2 2.2 8.1 0.0 2.9 3 0 0 3 3 3 2 Domain of unknown function DUF87 PRK PF00485.16 133401.1_45729001_2 - 0.0016 18.1 0.0 1.1 8.8 0.0 2.4 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family ATP-synt_ab PF00006.23 133401.1_45729001_2 - 0.0016 18.0 0.5 2 7.8 0.0 3.4 3 0 0 3 3 3 1 ATP synthase alpha/beta family, nucleotide-binding domain RNA_helicase PF00910.20 133401.1_45729001_2 - 0.0021 18.3 0.0 4.4 7.6 0.0 3.1 2 0 0 2 2 2 1 RNA helicase AAA_18 PF13238.4 133401.1_45729001_2 - 0.0022 18.4 0.0 2.6 8.4 0.0 2.9 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.11 133401.1_45729001_2 - 0.0044 16.1 0.1 2 7.4 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_21 PF13304.4 133401.1_45729001_2 - 0.0048 16.6 0.3 10 5.7 0.0 3.9 4 1 0 5 5 4 0 AAA domain, putative AbiEii toxin, Type IV TA system Mg_chelatase PF01078.19 133401.1_45729001_2 - 0.01 15.1 0.0 4.3 6.5 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.15 133401.1_45729001_2 - 0.014 15.0 1.7 26 4.4 0.0 4.2 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_24 PF13479.4 133401.1_45729001_2 - 0.018 14.7 0.0 5.1 6.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain tRNA_lig_kinase PF08303.9 133401.1_45729001_2 - 0.02 14.8 0.0 6.7 6.6 0.0 2.5 2 0 0 2 2 2 0 tRNA ligase kinase domain NACHT PF05729.10 133401.1_45729001_2 - 0.022 14.6 0.1 5.2 6.8 0.0 2.4 2 0 0 2 2 2 0 NACHT domain AAA_33 PF13671.4 133401.1_45729001_2 - 0.03 14.3 0.0 6.7 6.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.4 133401.1_45729001_2 - 0.034 13.6 0.1 4.8 6.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.13 133401.1_45729001_2 - 0.069 12.9 0.7 1.3 8.8 0.1 2.7 3 0 0 3 3 2 0 NTPase MMR_HSR1 PF01926.21 133401.1_45729001_2 - 0.13 12.2 0.0 12 5.9 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase PduV-EutP PF10662.7 133401.1_45729001_2 - 0.14 11.8 3.5 24 4.5 0.0 3.7 4 0 0 4 4 3 0 Ethanolamine utilisation - propanediol utilisation TLV_coat PF00429.17 015554.2_32925120_2 - 7.1e-51 173.4 2.8 4.3e-50 170.8 2.9 2.1 2 1 0 2 2 2 1 ENV polyprotein (coat polyprotein) TLV_coat PF00429.17 015554.2_32925120_3 - 2.2e-62 211.4 2.0 5.1e-52 177.2 0.5 2.1 2 0 0 2 2 2 2 ENV polyprotein (coat polyprotein) RIC3 PF15361.4 001346694.1_26229001_2 - 2.9e-29 102.2 0.0 4.9e-29 101.5 0.0 1.3 1 0 0 1 1 1 1 Resistance to inhibitors of cholinesterase homologue 3 DUF1725 PF08333.9 005391.4_26224001_1 - 0.025 14.1 0.1 0.04 13.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) BCDHK_Adom3 PF10436.7 005391.4_26224001_2 - 1.4e-50 171.1 0.0 2e-50 170.6 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.24 005391.4_26224001_2 - 1.1e-11 45.2 0.0 1.7e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.4 005391.4_26224001_2 - 0.088 12.5 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Hormone_1 PF00103.18 001009306.1_39522001_1 - 2.4e-81 272.4 0.0 3.1e-81 272.1 0.0 1.1 1 0 0 1 1 1 1 Somatotropin hormone family SRP-alpha_N PF04086.11 001177847.1_32929001_1 - 3.3 7.4 4.8 5.2 6.8 4.8 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal TIR_2 PF13676.4 001177847.1_32929001_3 - 7e-11 42.2 0.0 1.2e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 TIR domain TIR PF01582.18 001177847.1_32929001_3 - 2.8e-05 23.9 0.1 5.9e-05 22.8 0.0 1.6 2 0 0 2 2 2 1 TIR domain MBOAT PF03062.17 001146083.2_26225001_2 - 4.3e-31 108.4 8.1 6.7e-31 107.8 8.1 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family DUF1925 PF09094.9 001146083.2_26225001_2 - 0.13 12.5 0.7 0.25 11.5 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1925) LNS2 PF08235.11 146080.1_26229120_1 - 8.8e-85 283.6 0.0 1.5e-84 282.9 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.12 146080.1_26229120_1 - 8.7e-45 150.8 0.0 1.4e-44 150.1 0.0 1.3 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.3 146080.1_26229120_1 - 1.4e-32 111.7 0.0 2.8e-32 110.8 0.0 1.5 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain LNS2 PF08235.11 146080.1_26229120_3 - 1.5e-10 40.8 0.0 2.2e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) WRNPLPNID PF15017.4 146080.1_26229120_3 - 0.033 14.9 1.6 0.07 13.9 1.6 1.5 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box DUF1866 PF08952.9 151772.1_32929120_3 - 1.4e-59 200.0 0.1 2.1e-59 199.4 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1866) Syja_N PF02383.16 151772.1_32929120_3 - 2e-49 168.4 0.0 3.1e-49 167.9 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.21 151772.1_32929120_3 - 3.3e-07 30.4 0.0 7.1e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family BAR_3 PF16746.3 001358100.1_39729001_1 - 1e-84 283.9 17.8 1.4e-84 283.4 17.8 1.2 1 0 0 1 1 1 1 BAR domain of APPL family RhoGAP PF00620.25 001358100.1_39729001_1 - 3.1e-39 134.1 0.2 1.3e-38 132.1 0.1 1.9 2 0 0 2 2 2 1 RhoGAP domain SH3_9 PF14604.4 001358100.1_39729001_1 - 5e-08 32.5 0.0 9.9e-08 31.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 001358100.1_39729001_1 - 6.1e-05 22.4 0.0 0.0001 21.7 0.0 1.4 1 0 0 1 1 1 1 SH3 domain IMD PF08397.9 001358100.1_39729001_1 - 0.45 9.7 6.8 0.82 8.9 6.8 1.3 1 0 0 1 1 1 0 IRSp53/MIM homology domain STAG PF08514.9 001358225.1_32929001_1 - 7.1e-38 128.9 0.7 3.9e-37 126.5 0.1 2.5 2 0 0 2 2 2 1 STAG domain AdoHcyase_NAD PF00670.19 001358225.1_32929001_1 - 0.074 13.0 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain DUF4521 PF15021.4 001358261.1_32923001_2 - 8.2e-96 319.7 5.4 9.9e-96 319.5 5.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4521) FAM75 PF14650.4 152159.2_32927120_2 - 2.4e-09 37.1 9.3 9.7e-08 31.8 5.2 4.7 4 1 1 5 5 5 3 FAM75 family DUF1049 PF06305.9 132743.1_45721120_2 - 0.00078 19.1 0.1 0.0014 18.3 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1049) ATP-synt_C PF00137.19 001009396.1_39522001_1 - 2.6e-11 43.6 12.4 4e-11 42.9 12.4 1.3 1 0 0 1 1 1 1 ATP synthase subunit C YopE PF03545.11 001009396.1_39522001_3 - 0.065 13.3 0.1 0.11 12.6 0.1 1.3 1 0 0 1 1 1 0 Yersinia virulence determinant (YopE) ATP-synt_C PF00137.19 001304896.1_01322001_3 - 1.7e-11 44.1 12.4 3.2e-11 43.2 12.4 1.4 1 0 0 1 1 1 1 ATP synthase subunit C ATP-synt_G PF04718.13 001131168.2_43521001_3 - 4.7e-27 94.6 0.1 6.2e-27 94.2 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial ATP synthase g subunit ATP-synt_C PF00137.19 001309187.1_21022001_2 - 3.3e-11 43.2 12.4 5.7e-11 42.5 12.4 1.4 1 0 0 1 1 1 1 ATP synthase subunit C ATP-synt_E PF05680.10 213915.2_49821001_2 - 9.8e-18 64.2 0.3 9.8e-18 64.2 0.3 1.9 2 0 0 2 2 2 1 ATP synthase E chain Mt_ATP-synt_D PF05873.10 001193605.1_29622001_1 - 6.9e-67 224.0 7.1 7.9e-67 223.8 7.1 1.0 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) OSCP PF00213.16 001171421.1_37922001_1 - 8.1e-45 152.9 1.4 9.3e-45 152.7 1.4 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit OSCP PF00213.16 001165889.2_39522001_1 - 5.6e-47 159.9 0.4 6.9e-47 159.6 0.4 1.1 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit ATP-synt_ab PF00006.23 001266412.1_29624001_3 - 9.5e-75 250.8 0.0 1.4e-74 250.2 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.25 001266412.1_29624001_3 - 1.7e-47 160.7 1.3 2.7e-47 160.1 1.3 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.21 001266412.1_29624001_3 - 8.9e-17 61.2 1.4 2.2e-16 60.0 1.4 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF4142 PF13628.4 001266412.1_29624001_3 - 0.00016 21.8 0.9 0.00032 20.8 0.9 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4142) ATP-synt_F6 PF05511.9 001257938.1_29622001_3 - 4.4e-44 148.7 0.4 5.6e-44 148.4 0.4 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase coupling factor 6 ATP-synt_C PF00137.19 001244862.1_49822001_3 - 3.4e-11 43.2 12.4 6e-11 42.4 12.4 1.4 1 0 0 1 1 1 1 ATP synthase subunit C ATP-synt_ab PF00006.23 001281700.1_31324001_2 - 1.3e-74 250.3 0.0 2e-74 249.7 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.25 001281700.1_31324001_2 - 5.7e-47 159.0 1.2 9.1e-47 158.4 1.2 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.21 001281700.1_31324001_2 - 9.4e-17 61.2 1.2 2.4e-16 59.9 1.2 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF4142 PF13628.4 001281700.1_31324001_2 - 0.0019 18.3 0.3 0.0039 17.3 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4142) OSCP PF00213.16 001168788.1_40422001_1 - 4.1e-45 153.8 1.5 4.7e-45 153.7 1.5 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit ATP-synt_C PF00137.19 001251821.1_09923001_3 - 1.3e-10 41.3 12.4 1.3e-10 41.3 12.4 1.7 2 0 0 2 2 2 1 ATP synthase subunit C ATP-synt_C PF00137.19 001009468.1_39522001_1 - 2.4e-11 43.7 12.4 4e-11 43.0 12.4 1.4 1 0 0 1 1 1 1 ATP synthase subunit C ATP_synth_reg PF14960.4 001113318.1_06521001_2 - 3.7e-28 96.7 0.2 5.2e-28 96.2 0.2 1.2 1 0 0 1 1 1 1 ATP synthase regulation Aldedh PF00171.20 001011975.1_45725001_2 - 2.4e-184 613.0 0.0 2.8e-184 612.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family ubiquitin PF00240.21 001013899.1_45725001_2 - 2.7e-15 55.7 0.5 5.9e-15 54.6 0.5 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 001013899.1_45725001_2 - 3.7e-07 29.7 0.1 7.9e-07 28.7 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.29 001013899.1_45725001_2 - 0.013 15.3 1.7 0.014 15.1 0.1 2.0 2 0 0 2 2 2 0 UBA/TS-N domain YukD PF08817.8 001013899.1_45725001_2 - 0.069 13.7 0.0 0.21 12.2 0.0 1.9 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD Rad60-SLD_2 PF13881.4 001013899.1_45725001_2 - 0.09 12.8 0.1 0.27 11.2 0.1 1.8 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF4211 PF13926.4 001013899.1_45725001_2 - 0.14 12.0 0.6 1.7 8.6 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4211) SNAP-25 PF00835.17 001009094.1_39725001_2 - 1.4e-20 73.1 0.2 2.8e-20 72.2 0.2 1.5 1 0 0 1 1 1 1 SNAP-25 family DUF5089 PF17002.3 001009094.1_39725001_2 - 1.2e-05 25.1 4.9 1.8e-05 24.6 4.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5089) Exonuc_VII_L PF02601.13 001009094.1_39725001_2 - 0.66 9.4 5.8 2.4 7.5 5.8 1.8 1 1 0 1 1 1 0 Exonuclease VII, large subunit V-SNARE_C PF12352.6 001009094.1_39725001_2 - 0.78 9.9 5.9 0.29 11.3 0.7 2.8 2 2 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus Spc7 PF08317.9 001009094.1_39725001_2 - 2.4 6.8 9.1 0.31 9.8 2.4 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Snapin_Pallidin PF14712.4 001009094.1_39725001_2 - 2.8 8.3 9.8 4.6 7.6 4.2 2.5 2 0 0 2 2 2 0 Snapin/Pallidin IncA PF04156.12 001009094.1_39725001_2 - 3.7 7.2 7.6 0.63 9.7 2.7 1.9 2 0 0 2 2 2 0 IncA protein Alanine_zipper PF11839.6 001009094.1_39725001_2 - 4.3 7.6 7.6 7 6.9 0.1 3.2 2 1 1 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein Lectin_C PF00059.19 001009017.1_39722001_2 - 6.9e-08 33.1 0.5 6.9e-08 33.1 0.5 1.6 2 0 0 2 2 2 1 Lectin C-type domain UL45 PF05473.10 001009017.1_39722001_2 - 0.00026 20.6 1.2 0.00033 20.2 1.2 1.4 1 1 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Chordopox_A33R PF05966.10 001009017.1_39722001_2 - 0.011 14.9 0.1 0.022 13.9 0.1 1.5 1 0 0 1 1 1 0 Chordopoxvirus A33R protein Cadherin PF00028.15 001012748.1_45725001_1 - 2.4e-82 271.4 2.9 3.5e-18 65.7 0.1 5.2 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.15 001012748.1_45725001_1 - 2.1e-49 167.1 0.1 4.5e-49 166.0 0.1 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_3 PF16184.3 001012748.1_45725001_1 - 4.5e-07 29.7 2.1 0.51 10.2 0.0 4.8 4 0 0 4 4 4 2 Cadherin-like Cadherin_2 PF08266.10 001012748.1_45725001_1 - 4.8e-06 26.2 0.0 0.35 10.6 0.0 4.3 4 0 0 4 4 4 2 Cadherin-like Methyltransf_31 PF13847.4 080890.1_45724001_1 - 4.6e-31 107.5 0.0 1.3e-30 106.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.4 080890.1_45724001_1 - 2.1e-16 60.3 0.0 4.1e-16 59.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.10 080890.1_45724001_1 - 3.5e-15 56.3 0.0 6.3e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.16 080890.1_45724001_1 - 9.2e-13 47.9 0.0 1.4e-12 47.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.4 080890.1_45724001_1 - 1.2e-12 47.9 0.0 2.8e-12 46.7 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.10 080890.1_45724001_1 - 2.3e-11 44.2 0.0 4.3e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.17 080890.1_45724001_1 - 3.2e-06 26.9 0.1 5e-06 26.3 0.1 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.11 080890.1_45724001_1 - 0.00066 19.0 0.0 0.001 18.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_8 PF05148.13 080890.1_45724001_1 - 0.0011 18.7 0.1 0.0062 16.3 0.0 2.0 1 1 0 2 2 2 1 Hypothetical methyltransferase TehB PF03848.12 080890.1_45724001_1 - 0.013 14.8 0.0 0.028 13.7 0.0 1.5 1 0 0 1 1 1 0 Tellurite resistance protein TehB GidB PF02527.13 080890.1_45724001_1 - 0.015 14.5 0.0 0.024 13.8 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G MTS PF05175.12 080890.1_45724001_1 - 0.027 13.9 0.0 0.055 12.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain FtsJ PF01728.17 080890.1_45724001_1 - 0.038 14.0 0.0 0.06 13.3 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_32 PF13679.4 080890.1_45724001_1 - 0.084 12.7 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain TF_AP-2 PF03299.12 001009745.1_39528001_3 - 7e-86 287.1 0.0 9.6e-86 286.6 0.0 1.2 1 0 0 1 1 1 1 Transcription factor AP-2 Asp PF00026.21 001009804.1_39523001_1 - 3.1e-117 391.4 2.5 3.7e-117 391.1 2.5 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001009804.1_39523001_1 - 5.8e-13 49.3 0.3 2e-09 37.8 0.1 2.6 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001009804.1_39523001_1 - 4.4e-11 42.3 0.3 7.5e-11 41.5 0.3 1.4 1 0 0 1 1 1 1 A1 Propeptide AMP-binding PF00501.26 001034951.1_45727001_2 - 4e-98 328.6 0.0 5e-98 328.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.4 001034951.1_45727001_2 - 3.4e-17 63.1 0.0 7.1e-17 62.0 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Glyco_hydro_18 PF00704.26 001009779.1_39525001_2 - 9.3e-79 265.2 0.0 1.1e-78 265.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Asp PF00026.21 213809.1_49823001_1 - 3.9e-95 318.8 0.0 4.5e-95 318.5 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 213809.1_49823001_1 - 7.4e-14 52.3 1.8 3e-07 30.7 0.1 2.8 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 213809.1_49823001_1 - 2.8e-12 46.1 1.2 5.6e-12 45.1 1.2 1.5 1 0 0 1 1 1 1 A1 Propeptide Tetraspannin PF00335.18 001009023.1_39722001_1 - 4.5e-47 160.4 13.5 5.2e-47 160.2 13.5 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF21 PF01595.18 001009023.1_39722001_1 - 6 6.4 7.2 3.5 7.2 0.2 2.4 3 0 0 3 3 3 0 Domain of unknown function DUF21 EPO_TPO PF00758.16 001024737.1_39522001_1 - 6.4e-65 217.9 0.0 7.4e-65 217.7 0.0 1.0 1 0 0 1 1 1 1 Erythropoietin/thrombopoietin PH PF00169.27 053417.1_45725001_1 - 5.1e-21 75.0 2.4 9.4e-21 74.2 0.5 2.5 3 0 0 3 3 3 1 PH domain PH_11 PF15413.4 053417.1_45725001_1 - 4.5e-06 26.9 4.8 4.8e-05 23.6 4.8 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.4 053417.1_45725001_1 - 0.014 15.4 0.7 0.082 12.9 0.7 2.1 1 1 0 1 1 1 0 PH domain PH_2 PF08458.8 053417.1_45725001_1 - 0.017 15.3 0.0 0.041 14.1 0.0 1.6 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PH_9 PF15410.4 053417.1_45725001_1 - 0.058 13.6 0.0 0.2 11.9 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain PH_8 PF15409.4 053417.1_45725001_1 - 0.12 12.6 0.5 0.27 11.4 0.5 1.7 1 1 0 1 1 1 0 Pleckstrin homology domain EPO_TPO PF00758.16 214134.1_49823001_3 - 1.2e-66 223.5 0.1 1.6e-66 223.1 0.1 1.1 1 0 0 1 1 1 1 Erythropoietin/thrombopoietin Prenyltrans PF00432.19 138708.2_45723001_1 - 2.9e-69 228.3 8.2 1.1e-15 56.9 0.1 5.6 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.4 138708.2_45723001_1 - 0.0014 17.7 0.0 0.0023 16.9 0.0 1.3 1 0 0 1 1 1 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.4 138708.2_45723001_1 - 0.029 13.3 0.0 1.2 8.0 0.0 2.9 3 1 1 4 4 4 0 Squalene-hopene cyclase N-terminal domain LSM PF01423.20 001033972.1_32322001_3 - 5.1e-19 67.6 0.1 6.6e-19 67.2 0.1 1.1 1 0 0 1 1 1 1 LSM domain Lectin_C PF00059.19 213805.1_49824001_3 - 3e-15 56.7 0.4 9.4e-15 55.1 0.0 1.9 2 0 0 2 2 2 1 Lectin C-type domain UL45 PF05473.10 213805.1_49824001_3 - 4.6e-06 26.3 0.0 0.00067 19.2 0.0 2.4 2 0 0 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like Ly49 PF08391.8 213805.1_49824001_3 - 6.6e-05 23.1 5.3 0.00015 22.0 5.3 1.7 1 1 0 1 1 1 1 Ly49-like protein, N-terminal region IncA PF04156.12 213805.1_49824001_3 - 0.00015 21.4 6.6 0.00027 20.6 6.6 1.3 1 0 0 1 1 1 1 IncA protein FAM176 PF14851.4 213805.1_49824001_3 - 0.00051 19.6 0.5 0.00093 18.8 0.5 1.4 1 0 0 1 1 1 1 FAM176 family HemX PF04375.12 213805.1_49824001_3 - 0.0019 17.4 7.8 0.0028 16.9 7.8 1.1 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase TALPID3 PF15324.4 213805.1_49824001_3 - 0.1 10.1 1.8 0.13 9.8 1.8 1.0 1 0 0 1 1 1 0 Hedgehog signalling target Vpu PF00558.17 213805.1_49824001_3 - 0.23 11.1 2.9 0.12 12.0 0.5 1.7 2 0 0 2 2 2 0 Vpu protein GspL_C PF12693.5 213805.1_49824001_3 - 0.24 11.1 5.8 0.4 10.4 5.8 1.3 1 0 0 1 1 1 0 GspL periplasmic domain DUF4446 PF14584.4 213805.1_49824001_3 - 0.36 10.7 3.1 0.62 9.9 3.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Bap31 PF05529.10 213805.1_49824001_3 - 0.51 9.8 8.4 0.85 9.1 8.4 1.2 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like Lectin_C PF00059.19 001032889.1_29622001_1 - 1.5e-17 64.2 1.1 3.2e-17 63.1 1.1 1.6 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.10 001032889.1_29622001_1 - 7.1e-05 22.4 6.3 0.0002 21.0 6.3 1.6 1 1 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Chordopox_A33R PF05966.10 001032889.1_29622001_1 - 0.00083 18.6 0.1 0.0012 18.0 0.1 1.4 1 0 0 1 1 1 1 Chordopoxvirus A33R protein Innexin PF00876.16 199398.1_45725001_1 - 5.2e-08 32.4 0.9 8.2e-08 31.8 0.9 1.2 1 0 0 1 1 1 1 Innexin 7tm_1 PF00001.19 013115.1_45726001_2 - 3.3e-15 55.9 10.4 3.3e-15 55.9 10.4 1.8 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) Serpentine_r_xa PF03383.13 013115.1_45726001_2 - 0.0017 18.2 1.3 0.0048 16.7 0.6 2.1 1 1 1 2 2 2 1 Caenorhabditis serpentine receptor-like protein, class xa Syntaxin PF00804.23 012748.1_45722001_1 - 2.3e-64 216.6 14.3 2.3e-64 216.6 14.3 1.7 2 0 0 2 2 2 1 Syntaxin SNARE PF05739.17 012748.1_45722001_1 - 2.2e-16 59.5 5.0 2.3e-16 59.4 1.6 2.4 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.4 012748.1_45722001_1 - 1.7e-09 37.8 2.9 1.7e-09 37.8 2.9 2.4 2 1 0 2 2 2 1 Syntaxin-like protein DUF3671 PF12420.6 012748.1_45722001_1 - 0.0014 18.6 1.8 0.0015 18.5 0.1 2.0 2 0 0 2 2 1 1 Protein of unknown function ETRAMP PF09716.8 012748.1_45722001_1 - 0.003 17.4 2.6 0.061 13.3 2.6 2.6 1 1 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) Syntaxin-6_N PF09177.9 012748.1_45722001_1 - 0.0043 17.4 0.2 0.0043 17.4 0.2 2.8 1 1 1 2 2 2 1 Syntaxin 6, N-terminal ApoLp-III PF07464.9 012748.1_45722001_1 - 0.022 14.7 5.5 0.29 11.1 0.6 2.4 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) RRM_3 PF08777.9 012748.1_45722001_1 - 0.027 14.4 1.4 6 6.8 0.4 2.8 2 1 0 2 2 2 0 RNA binding motif DUF2207 PF09972.7 012748.1_45722001_1 - 0.051 12.2 1.3 0.26 9.9 0.1 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) CbiA PF01656.21 012748.1_45722001_1 - 0.078 12.9 1.4 0.47 10.4 0.1 2.1 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF2205 PF10224.7 012748.1_45722001_1 - 0.09 12.7 0.1 0.09 12.7 0.1 3.7 4 1 1 5 5 5 0 Predicted coiled-coil protein (DUF2205) COG5 PF10392.7 012748.1_45722001_1 - 0.13 12.3 5.8 1.8 8.6 0.7 2.8 2 1 1 3 3 3 0 Golgi transport complex subunit 5 CwsA PF10814.6 012748.1_45722001_1 - 0.15 12.1 0.4 0.35 10.9 0.1 1.8 2 0 0 2 2 1 0 Cell wall synthesis protein CwsA DUF2116 PF09889.7 012748.1_45722001_1 - 0.16 11.8 0.5 0.36 10.7 0.5 1.6 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) WXG100 PF06013.10 012748.1_45722001_1 - 0.17 12.0 2.2 15 5.8 0.1 3.4 3 1 1 4 4 4 0 Proteins of 100 residues with WXG MCPsignal PF00015.19 012748.1_45722001_1 - 0.22 11.1 8.3 1.9 8.1 2.6 2.4 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF3899 PF13038.4 012748.1_45722001_1 - 0.26 11.7 0.9 11 6.5 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF3899) Zip PF02535.20 012748.1_45722001_1 - 0.41 9.7 2.8 0.22 10.5 0.2 1.7 2 0 0 2 2 2 0 ZIP Zinc transporter DUF1910 PF08928.8 012748.1_45722001_1 - 0.65 9.9 8.3 2.7 7.9 1.2 2.8 3 1 0 3 3 2 0 Domain of unknown function (DUF1910) DUF16 PF01519.14 012748.1_45722001_1 - 0.73 10.2 10.4 0.097 13.0 1.6 2.6 2 1 0 2 2 2 0 Protein of unknown function DUF16 Nup54 PF13874.4 012748.1_45722001_1 - 1.3 8.9 10.3 0.73 9.8 2.6 3.0 1 1 2 4 4 4 0 Nucleoporin complex subunit 54 FlaC_arch PF05377.9 012748.1_45722001_1 - 7.1 7.0 9.4 15 5.9 0.0 4.0 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) TMPIT PF07851.11 012748.1_45722001_1 - 8.7 5.3 10.1 3.4 6.7 1.2 2.1 1 1 0 2 2 2 0 TMPIT-like protein Lectin_C PF00059.19 001009049.1_39722001_3 - 7.2e-09 36.2 0.4 1.2e-08 35.5 0.4 1.3 1 0 0 1 1 1 1 Lectin C-type domain 7tm_1 PF00001.19 001009726.1_39524001_1 - 2.8e-46 157.8 23.4 5.2e-46 156.9 23.4 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001009726.1_39524001_1 - 2.4e-11 43.4 20.4 3e-11 43.0 20.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001009726.1_39524001_1 - 6.2e-09 35.4 25.6 2.2e-08 33.6 25.1 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001009726.1_39524001_1 - 0.00024 20.8 16.8 0.0072 16.0 16.8 2.2 1 1 0 1 1 1 1 Olfactory receptor Git3 PF11710.6 001009726.1_39524001_1 - 3.2 7.4 27.4 0.013 15.2 17.6 1.8 2 1 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 4HBT_2 PF13279.4 001007658.1_45724001_1 - 9.5e-23 80.9 0.0 1.3e-22 80.4 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.20 001007658.1_45724001_1 - 0.00043 20.4 0.4 0.00081 19.6 0.4 1.4 1 0 0 1 1 1 1 Thioesterase superfamily UCH PF00443.27 001045496.1_39726001_3 - 1.2e-50 172.3 1.8 1.6e-50 171.9 1.8 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 001045496.1_39726001_3 - 5e-14 52.5 9.3 9.9e-14 51.5 9.3 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.21 001045496.1_39726001_3 - 0.00092 18.8 0.0 0.0018 17.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Asp PF00026.21 001009462.1_39523001_3 - 9.9e-99 330.6 0.0 1.2e-98 330.3 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001009462.1_39523001_3 - 1.7e-15 57.6 0.2 8.6e-14 52.0 0.2 2.2 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001009462.1_39523001_3 - 4.8e-13 48.5 1.0 1.1e-12 47.4 1.0 1.6 1 0 0 1 1 1 1 A1 Propeptide Asp_protease_2 PF13650.4 001009462.1_39523001_3 - 0.00011 22.6 0.0 0.055 14.0 0.0 3.1 3 1 0 3 3 3 1 Aspartyl protease gag-asp_proteas PF13975.4 001009462.1_39523001_3 - 0.068 13.6 0.0 8.4 6.9 0.0 2.8 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease 7tm_1 PF00001.19 001032885.1_29623001_2 - 1.4e-45 155.5 19.1 1.7e-45 155.2 19.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001032885.1_29623001_2 - 9.9e-09 34.8 16.7 1.3e-08 34.4 16.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001032885.1_29623001_2 - 0.00032 20.0 9.0 0.00032 20.0 9.0 2.2 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001032885.1_29623001_2 - 0.29 10.7 15.7 1.5 8.3 15.7 1.9 1 1 0 1 1 1 0 Olfactory receptor EF-hand_1 PF00036.30 021701.2_45722001_1 - 1.9e-26 89.5 12.8 4.1e-07 29.0 0.3 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.4 021701.2_45722001_1 - 6.3e-22 75.5 7.1 3.5e-05 23.3 0.3 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.4 021701.2_45722001_1 - 3.3e-20 70.5 11.8 5.4e-06 25.5 0.5 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 021701.2_45722001_1 - 1.8e-19 69.8 10.7 1.3e-11 44.7 1.3 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.4 021701.2_45722001_1 - 2.4e-14 52.7 11.7 0.0036 16.9 0.0 4.2 4 0 0 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.7 021701.2_45722001_1 - 8e-05 22.8 0.0 0.45 10.7 0.0 2.6 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 021701.2_45722001_1 - 0.00053 19.8 6.0 0.98 9.3 0.0 3.6 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.4 021701.2_45722001_1 - 0.016 15.4 0.3 0.31 11.3 0.0 2.6 3 0 0 3 3 3 0 EF-hand domain Pkinase PF00069.23 001009322.1_22424001_3 - 7.1e-65 218.8 0.0 9.1e-65 218.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001009322.1_22424001_3 - 4e-21 75.3 0.0 5.7e-21 74.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001009322.1_22424001_3 - 5.7e-09 35.6 0.0 8.1e-09 35.1 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 001009322.1_22424001_3 - 1.2e-06 27.9 0.0 1.8e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001009322.1_22424001_3 - 0.04 13.7 0.4 0.073 12.8 0.1 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.9 001009322.1_22424001_3 - 0.21 10.5 0.0 0.33 9.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Choline_kinase PF01633.18 001009322.1_22424001_3 - 0.23 10.9 0.0 0.36 10.2 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase PF00069.23 001032925.1_29622001_1 - 8e-41 140.0 0.0 9.7e-41 139.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001032925.1_29622001_1 - 1.4e-20 73.5 0.0 1.8e-20 73.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 001032925.1_29622001_1 - 0.0024 17.7 0.1 0.011 15.5 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.4 001032925.1_29622001_1 - 0.019 14.1 0.1 0.67 9.1 0.1 2.1 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.12 001032925.1_29622001_1 - 0.094 11.9 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.23 001032925.1_29622001_3 - 0.065 12.4 0.0 0.082 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain Lectin_C PF00059.19 031649.2_45722001_1 - 2.9e-12 47.1 0.3 4.8e-12 46.5 0.3 1.3 1 0 0 1 1 1 1 Lectin C-type domain Corona_S2 PF01601.14 031649.2_45722001_1 - 8.8 4.5 7.8 18 3.5 6.7 1.8 1 1 0 2 2 2 0 Coronavirus S2 glycoprotein Repressor_Mnt PF11423.6 001009053.1_39722001_1 - 0.16 11.6 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Regulatory protein Mnt UL45 PF05473.10 001009053.1_39722001_2 - 0.0067 15.9 0.0 0.009 15.5 0.0 1.2 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Asp PF00026.21 001032980.1_32323001_2 - 1.1e-111 373.1 3.2 1.3e-111 372.8 3.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001032980.1_32323001_2 - 3.9e-14 53.2 1.9 3.7e-10 40.2 0.2 2.4 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001032980.1_32323001_2 - 4.1e-08 32.8 0.1 9e-08 31.7 0.1 1.5 1 0 0 1 1 1 1 A1 Propeptide TAXi_C PF14541.4 001032980.1_32323001_2 - 1.1e-05 25.1 0.0 3.7e-05 23.4 0.0 2.0 2 1 0 2 2 2 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.4 001032980.1_32323001_2 - 0.0026 18.3 0.0 0.1 13.2 0.0 2.6 2 1 0 2 2 2 1 Aspartyl protease PKI PF02827.14 214371.1_49822001_1 - 1.5e-28 98.6 0.3 2.4e-28 98.0 0.3 1.3 1 0 0 1 1 1 1 cAMP-dependent protein kinase inhibitor BIR PF00653.19 214141.1_49822001_3 - 3.9e-23 81.8 2.1 3.9e-23 81.8 2.1 1.7 2 0 0 2 2 2 1 Inhibitor of Apoptosis domain Asp PF00026.21 001009354.1_39523001_3 - 4.1e-99 331.8 0.0 4.9e-99 331.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease A1_Propeptide PF07966.10 001009354.1_39523001_3 - 2.1e-15 56.1 2.7 3.6e-15 55.3 2.7 1.4 1 0 0 1 1 1 1 A1 Propeptide TAXi_N PF14543.4 001009354.1_39523001_3 - 5e-15 56.1 0.1 3.8e-07 30.4 0.0 2.3 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.4 001009354.1_39523001_3 - 0.0011 19.5 0.0 0.062 13.9 0.0 2.9 2 1 0 2 2 2 1 Aspartyl protease Lectin_C PF00059.19 001009048.2_39723001_1 - 8.6e-09 36.0 0.4 8.6e-09 36.0 0.4 1.8 2 0 0 2 2 2 1 Lectin C-type domain UL45 PF05473.10 001009048.2_39723001_1 - 2.5e-08 33.7 0.1 4.2e-08 32.9 0.1 1.4 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Tetraspannin PF00335.18 001009855.1_22422001_1 - 9e-49 166.0 17.7 1e-48 165.8 17.7 1.0 1 0 0 1 1 1 1 Tetraspanin family Pro_isomerase PF00160.19 001009370.1_22422001_1 - 2.8e-45 154.3 0.2 3.4e-45 154.0 0.2 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Globin PF00042.20 214447.1_49821001_3 - 2.8e-29 101.8 0.0 8.8e-29 100.1 0.0 1.7 2 0 0 2 2 2 1 Globin Mito_carr PF00153.25 001037186.1_45723001_1 - 7e-54 179.6 0.3 4.1e-22 77.8 0.0 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF4604 PF15377.4 001037186.1_45723001_1 - 0.067 13.5 16.3 0.096 13.0 16.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) SR-25 PF10500.7 001037186.1_45723001_3 - 0.11 11.9 28.9 0.16 11.4 28.9 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pro_isomerase PF00160.19 214353.1_49822001_2 - 4.3e-47 160.2 0.2 4.8e-47 160.0 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Glyco_hydro_18 PF00704.26 214070.1_49825001_2 - 7e-80 268.9 0.0 8.4e-80 268.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Glyco_hydro_35 PF01301.17 001009860.1_22425001_2 - 9.9e-127 422.8 0.0 1.3e-126 422.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.13 001009860.1_22425001_2 - 1.1e-14 54.4 0.0 2.1e-12 47.0 0.0 2.4 1 1 0 1 1 1 1 Beta-galactosidase BetaGal_dom4_5 PF13364.4 001009860.1_22425001_2 - 4.8e-08 33.4 3.0 1e-07 32.4 0.1 2.8 3 1 1 4 4 4 1 Beta-galactosidase jelly roll domain Lectin_C PF00059.19 214125.1_49822001_1 - 2e-18 66.9 0.5 2e-18 66.9 0.5 1.4 2 0 0 2 2 2 1 Lectin C-type domain Collagen PF01391.16 214125.1_49822001_1 - 6.9e-09 35.2 18.4 1.6e-08 34.0 18.4 1.6 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) Tim17 PF02466.17 001007676.1_45723001_1 - 1e-13 51.4 5.6 1.9e-13 50.5 5.6 1.5 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Rick_17kDa_Anti PF05433.13 001007676.1_45723001_1 - 3.2 7.6 15.9 0.15 11.9 9.8 2.0 2 0 0 2 2 2 0 Glycine zipper 2TM domain DUF1180 PF06679.10 001012350.1_45723001_1 - 5.9e-68 228.4 0.6 7.8e-68 228.0 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) ACC_central PF08326.10 001009256.1_39529001_2 - 7.6e-284 943.2 7.2 9.4e-284 942.9 7.2 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.20 001009256.1_39529001_2 - 2.3e-183 610.3 0.0 3e-183 609.9 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.15 001009256.1_39529001_2 - 2.4e-54 183.9 0.0 4.6e-54 183.0 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.20 001009256.1_39529001_2 - 5.6e-31 107.2 0.0 1.2e-30 106.2 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.17 001009256.1_39529001_2 - 3.7e-22 78.3 0.0 1.8e-21 76.1 0.0 2.3 3 0 0 3 3 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.20 001009256.1_39529001_2 - 3.5e-17 61.9 0.0 9.7e-17 60.5 0.0 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.4 001009256.1_39529001_2 - 5.6e-07 28.4 0.0 0.0057 15.3 0.0 3.0 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.11 001009256.1_39529001_2 - 1.2e-05 24.9 0.0 2.7e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.20 001009256.1_39529001_2 - 1.2e-05 24.8 0.0 2.5e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.12 001009256.1_39529001_2 - 9.4e-05 22.4 0.0 0.00024 21.0 0.0 1.7 1 1 0 1 1 1 1 ATP-grasp domain DUF445 PF04286.10 001009256.1_39529001_2 - 0.83 9.3 2.9 4.2 6.9 0.3 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF445) ISK_Channel PF02060.13 001009206.1_22421001_1 - 5.5e-62 206.8 0.0 6.1e-62 206.6 0.0 1.0 1 0 0 1 1 1 1 Slow voltage-gated potassium channel Mito_carr PF00153.25 214049.1_49825001_2 - 8.9e-67 220.9 0.2 1.4e-23 82.5 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein RNA_pol_Rpb1_R PF05001.11 214049.1_49825001_2 - 2.9 8.3 6.3 0.29 11.4 1.0 2.3 2 0 0 2 2 2 0 RNA polymerase Rpb1 C-terminal repeat Pkinase PF00069.23 001009071.1_39723001_2 - 1.7e-59 201.2 0.0 2.2e-59 200.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001009071.1_39723001_2 - 1.3e-33 116.3 0.0 6.5e-32 110.7 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Seadorna_VP7 PF07387.9 001009071.1_39723001_2 - 0.017 14.1 0.0 0.025 13.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kinase-like PF14531.4 001009071.1_39723001_2 - 0.038 13.2 0.0 0.085 12.0 0.0 1.5 1 0 0 1 1 1 0 Kinase-like DUF3216 PF11505.6 001009071.1_39723001_2 - 0.058 13.6 0.3 0.12 12.5 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3216) SRC-1 PF08832.8 001009071.1_39723001_2 - 0.14 13.1 0.2 0.4 11.6 0.0 1.8 2 0 0 2 2 2 0 Steroid receptor coactivator Choline_kinase PF01633.18 001009071.1_39723001_2 - 0.15 11.5 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Lectin_C PF00059.19 001009064.1_39723001_1 - 1.4e-21 77.1 4.0 2.9e-21 76.1 4.0 1.5 1 0 0 1 1 1 1 Lectin C-type domain DUF2170 PF09938.7 001009064.1_39723001_1 - 8.6e-10 38.3 1.2 0.27 10.8 0.1 6.8 1 1 7 8 8 8 1 Uncharacterized protein conserved in bacteria (DUF2170) DUF2730 PF10805.6 001009064.1_39723001_1 - 4e-07 29.9 15.1 0.15 12.0 0.5 4.6 1 1 5 6 6 6 4 Protein of unknown function (DUF2730) Baculo_PEP_C PF04513.10 001009064.1_39723001_1 - 3.4e-06 27.0 5.3 0.027 14.4 0.4 3.0 1 1 2 3 3 3 3 Baculovirus polyhedron envelope protein, PEP, C terminus Mhr1 PF12829.5 001009064.1_39723001_1 - 1.2e-05 25.1 12.6 45 4.1 0.0 8.1 1 1 8 9 9 9 0 Transcriptional regulation of mitochondrial recombination Occludin_ELL PF07303.11 001009064.1_39723001_1 - 1.8e-05 25.2 20.8 0.24 12.0 1.8 4.3 1 1 4 5 5 5 3 Occludin homology domain DUF617 PF04759.11 001009064.1_39723001_1 - 0.00018 21.5 1.0 3.6 7.5 0.0 4.0 1 1 5 6 6 6 1 Protein of unknown function, DUF617 CHASE5 PF17149.2 001009064.1_39723001_1 - 0.00053 19.7 2.7 19 5.1 0.0 6.0 3 2 5 8 8 8 0 Periplasmic sensor domain found in signal transduction proteins Med4 PF10018.7 001009064.1_39723001_1 - 0.0016 18.0 24.8 0.34 10.4 2.7 4.4 1 1 5 6 6 6 4 Vitamin-D-receptor interacting Mediator subunit 4 DGCR6 PF07324.9 001009064.1_39723001_1 - 0.0017 17.9 23.4 0.57 9.6 2.6 4.6 1 1 5 6 6 6 3 DiGeorge syndrome critical region 6 (DGCR6) protein DUF3422 PF11902.6 001009064.1_39723001_1 - 0.0024 16.9 17.4 0.82 8.6 1.1 4.4 1 1 4 5 5 5 2 Protein of unknown function (DUF3422) DIMCO_N PF16844.3 001009064.1_39723001_1 - 0.0059 16.8 13.4 1.6 8.9 0.8 3.6 1 1 2 3 3 3 2 Dinitrogenase iron-molybdenum cofactor, N-terminal BLOC1_2 PF10046.7 001009064.1_39723001_1 - 0.0064 16.6 22.8 1.6 8.9 1.8 5.6 1 1 6 7 7 7 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2357 PF09823.7 001009064.1_39723001_1 - 0.013 14.7 15.3 0.56 9.3 0.3 3.9 1 1 4 5 5 5 0 Domain of unknown function (DUF2357) IL22 PF14565.4 001009064.1_39723001_1 - 0.017 15.3 5.0 13 5.9 0.1 3.9 1 1 4 5 5 5 0 Interleukin 22 IL-10-related T-cell-derived-inducible factor COMP PF11598.6 001009064.1_39723001_1 - 0.023 15.0 19.2 7.6 7.0 0.4 6.6 1 1 7 8 8 8 0 Cartilage oligomeric matrix protein LINES_C PF14695.4 001009064.1_39723001_1 - 0.033 13.5 0.0 25 4.3 0.1 5.4 9 0 0 9 9 9 0 Lines C-terminus Med10 PF09748.7 001009064.1_39723001_1 - 0.035 13.9 15.5 1.2e+02 2.6 0.3 4.3 1 1 1 2 2 2 0 Transcription factor subunit Med10 of Mediator complex DUF4795 PF16043.3 001009064.1_39723001_1 - 0.045 13.2 20.3 0.37 10.2 8.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) Vps5 PF09325.8 001009064.1_39723001_1 - 0.047 13.1 14.9 3.2 7.1 1.3 3.1 1 1 0 2 2 2 0 Vps5 C terminal like Transglut_core3 PF13471.4 001009064.1_39723001_1 - 0.066 13.0 0.1 0.29 10.9 0.0 2.1 2 1 0 2 2 1 0 Transglutaminase-like superfamily Phage_CP76 PF06892.9 001009064.1_39723001_1 - 0.07 12.5 8.4 0.29 10.5 0.2 3.6 1 1 3 5 5 5 0 Phage regulatory protein CII (CP76) YceG PF02618.14 001009064.1_39723001_1 - 0.079 12.4 10.6 3.3 7.1 4.0 2.8 1 1 1 2 2 2 0 YceG-like family DUF4665 PF15679.3 001009064.1_39723001_1 - 0.081 13.4 12.4 4.5 7.8 0.5 3.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4665) HCMV_UL139 PF12507.6 001009064.1_39723001_1 - 0.12 12.6 14.2 9.2 6.5 0.7 4.7 1 1 5 6 6 6 0 Human Cytomegalovirus UL139 protein tRNA-synt_His PF13393.4 001009064.1_39723001_1 - 0.12 11.5 13.8 3.2 6.8 1.9 3.4 1 1 1 3 3 3 0 Histidyl-tRNA synthetase DUF972 PF06156.11 001009064.1_39723001_1 - 0.18 12.3 20.5 12 6.5 4.2 4.3 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF2408 PF10303.7 001009064.1_39723001_1 - 0.2 12.1 23.9 7.5 7.0 0.5 5.3 1 1 2 3 3 3 0 Protein of unknown function (DUF2408) RP-C_C PF11800.6 001009064.1_39723001_1 - 0.2 11.5 14.3 15 5.4 10.0 3.7 1 1 1 2 2 2 0 Replication protein C C-terminal region DUF4477 PF14780.4 001009064.1_39723001_1 - 0.2 11.1 8.7 3.1 7.2 0.4 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4477) Cytochrom_B562 PF07361.9 001009064.1_39723001_1 - 0.23 12.0 12.7 2.5e+03 -0.9 13.0 3.7 1 1 0 1 1 1 0 Cytochrome b562 DUF1269 PF06897.10 001009064.1_39723001_1 - 0.43 10.7 6.8 41 4.4 0.2 3.7 1 1 5 6 6 6 0 Protein of unknown function (DUF1269) DUF4363 PF14276.4 001009064.1_39723001_1 - 0.5 10.3 10.4 3.6 7.5 1.3 3.8 1 1 4 5 5 5 0 Domain of unknown function (DUF4363) DUF3322 PF11795.6 001009064.1_39723001_1 - 1.2 9.0 7.1 25 4.6 1.3 3.4 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) NYD-SP28 PF14772.4 001009064.1_39723001_1 - 1.6 8.7 27.2 18 5.3 2.5 5.9 1 1 5 6 6 6 0 Sperm tail 5_3_exonuc PF01367.18 001009064.1_39723001_1 - 1.8 9.1 14.4 5.9 7.4 1.4 3.7 1 1 1 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold DUF3347 PF11827.6 001009064.1_39723001_1 - 2 8.4 15.0 2.4 8.2 6.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3347) Allexi_40kDa PF05549.9 001009064.1_39723001_1 - 2.2 7.6 7.4 2.9 7.2 0.6 2.4 1 1 1 2 2 2 0 Allexivirus 40kDa protein Kri1 PF05178.10 001009064.1_39723001_1 - 2.2 8.7 20.4 1.6e+04 -11.2 20.5 5.4 1 1 0 1 1 0 0 KRI1-like family DUF3375 PF11855.6 001009064.1_39723001_1 - 2.4 6.9 17.7 8.5 5.0 0.2 3.8 1 1 2 4 4 4 0 Protein of unknown function (DUF3375) GIT1_C PF12205.6 001009064.1_39723001_1 - 3 7.9 14.2 3.2 7.7 2.7 3.8 1 1 3 4 4 4 0 G protein-coupled receptor kinase-interacting protein 1 C term DUF4611 PF15387.4 001009064.1_39723001_1 - 7.9 6.7 8.6 18 5.5 0.4 3.4 1 1 2 3 3 3 0 Domain of unknown function (DUF4611) FlaC_arch PF05377.9 001009064.1_39723001_1 - 8.1 6.8 14.1 54 4.1 0.1 5.1 1 1 8 9 9 9 0 Flagella accessory protein C (FlaC) K-box PF01486.15 001009064.1_39723001_1 - 8.2 6.6 30.3 20 5.3 0.4 7.4 1 1 8 9 9 9 0 K-box region SNAP-25 PF00835.17 001032864.1_29622001_1 - 3.1e-21 75.3 0.2 8.2e-21 73.9 0.2 1.8 1 0 0 1 1 1 1 SNAP-25 family DUF5089 PF17002.3 001032864.1_29622001_1 - 1.6e-06 28.0 4.9 2.3e-06 27.5 4.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5089) IncA PF04156.12 001032864.1_29622001_1 - 0.039 13.6 4.7 0.13 11.9 2.7 2.0 2 0 0 2 2 2 0 IncA protein Exonuc_VII_L PF02601.13 001032864.1_29622001_1 - 0.16 11.4 7.3 0.95 8.8 7.3 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit Spc7 PF08317.9 001032864.1_29622001_1 - 0.21 10.3 9.1 0.073 11.8 2.4 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein MCPsignal PF00015.19 001032864.1_29622001_1 - 0.24 11.0 5.6 2.7 7.6 0.4 2.2 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain PMC2NT PF08066.10 001032864.1_29622001_1 - 0.25 11.9 3.2 1.7 9.2 0.3 2.7 2 1 0 2 2 2 0 PMC2NT (NUC016) domain Alanine_zipper PF11839.6 001032864.1_29622001_1 - 0.34 11.1 8.8 2.2 8.5 0.2 3.4 2 1 1 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein DUF1664 PF07889.10 001032864.1_29622001_1 - 0.6 10.0 7.9 1.7 8.5 1.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Snapin_Pallidin PF14712.4 001032864.1_29622001_1 - 0.68 10.3 11.4 3.4 8.0 5.8 2.5 2 1 0 2 2 2 0 Snapin/Pallidin Sec20 PF03908.11 001032864.1_29622001_1 - 0.71 9.7 3.4 0.41 10.5 0.6 2.0 2 0 0 2 2 2 0 Sec20 V_ATPase_I PF01496.17 001032864.1_29622001_1 - 0.74 7.5 2.5 0.53 8.0 1.1 1.3 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family V-SNARE_C PF12352.6 001032864.1_29622001_1 - 1.5 9.0 10.9 0.16 12.2 1.6 3.4 3 2 0 3 3 2 0 Snare region anchored in the vesicle membrane C-terminus SOAR PF16533.3 001032864.1_29622001_1 - 1.9 8.4 5.1 8.2 6.3 0.0 2.8 3 0 0 3 3 3 0 STIM1 Orai1-activating region TMPIT PF07851.11 001032864.1_29622001_1 - 1.9 7.5 5.1 1.3 8.1 0.8 2.0 2 0 0 2 2 2 0 TMPIT-like protein HisKA_3 PF07730.11 001032864.1_29622001_1 - 2 8.9 9.7 0.98 9.9 1.4 3.6 3 1 0 3 3 3 0 Histidine kinase DUF349 PF03993.10 001032864.1_29622001_1 - 2 8.6 5.0 1.2 9.4 0.1 2.7 3 0 0 3 3 3 0 Domain of Unknown Function (DUF349) Atg14 PF10186.7 001032864.1_29622001_1 - 4.3 6.2 8.6 8.7 5.2 0.5 2.2 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Golgin_A5 PF09787.7 001032864.1_29622001_1 - 5 6.4 12.9 1.1 8.6 5.9 2.0 2 0 0 2 2 2 0 Golgin subfamily A member 5 Laminin_II PF06009.10 001032864.1_29622001_1 - 5.7 6.8 9.2 11 5.9 0.8 2.8 2 1 1 3 3 3 0 Laminin Domain II DivIC PF04977.13 001032864.1_29622001_1 - 6.8 6.4 9.1 6.2 6.5 0.2 3.2 3 0 0 3 3 3 0 Septum formation initiator DUF4200 PF13863.4 001032864.1_29622001_1 - 9.2 6.6 13.9 11 6.3 1.7 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) Trypsin PF00089.24 214191.1_49823001_1 - 1.6e-70 237.2 0.0 2e-70 236.9 0.0 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.9 214191.1_49823001_1 - 9.4e-08 32.3 0.0 1.3e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.4 214191.1_49823001_1 - 1.1e-06 29.4 0.0 2.5e-06 28.3 0.0 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain PTPLA PF04387.12 001009443.1_39523001_1 - 6.3e-58 195.0 10.9 6.3e-58 195.0 10.9 1.4 2 0 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA DUF4383 PF14325.4 001009443.1_39523001_1 - 0.42 10.8 4.4 0.24 11.5 1.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4383) Pkinase PF00069.23 001009065.1_39723001_1 - 2e-65 220.6 0.0 2.4e-65 220.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001009065.1_39723001_1 - 6e-31 107.5 0.0 8.1e-31 107.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 001009065.1_39723001_1 - 6.5e-05 22.2 0.4 0.0001 21.6 0.4 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001009065.1_39723001_1 - 0.0078 16.0 0.5 0.034 13.9 0.0 2.1 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.4 001009065.1_39723001_1 - 0.074 12.2 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Kinase-like NAD_binding_8 PF13450.4 001009065.1_39723001_1 - 0.11 12.6 0.3 0.3 11.2 0.3 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Tetraspannin PF00335.18 001009070.1_39722001_1 - 1.5e-47 162.0 8.9 1.8e-47 161.7 8.9 1.0 1 0 0 1 1 1 1 Tetraspanin family Endonuclease_1 PF04231.11 001009070.1_39722001_1 - 0.03 13.9 0.2 0.044 13.3 0.2 1.2 1 0 0 1 1 1 0 Endonuclease I TM140 PF14985.4 001009709.1_45723001_3 - 2.5e-91 304.0 9.9 3.6e-91 303.5 9.9 1.2 1 0 0 1 1 1 1 TM140 protein family TMEM37 PF15108.4 001009709.1_45723001_3 - 0.084 12.6 9.8 0.024 14.4 6.6 1.7 2 1 0 2 2 2 0 Voltage-dependent calcium channel gamma-like subunit protein family Wzy_C PF04932.13 001009709.1_45723001_3 - 0.98 8.9 4.4 0.75 9.3 0.0 2.4 3 0 0 3 3 3 0 O-Antigen ligase Pkinase PF00069.23 001009293.1_39524001_1 - 2.8e-33 115.3 0.0 5e-33 114.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001009293.1_39524001_1 - 1.6e-30 106.1 0.0 2.7e-30 105.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Activin_recp PF01064.21 001009293.1_39524001_1 - 2.7e-05 25.0 12.9 2.7e-05 25.0 12.9 1.7 2 0 0 2 2 2 1 Activin types I and II receptor domain FTA2 PF13095.4 001009293.1_39524001_1 - 0.038 13.5 0.0 0.23 10.9 0.0 1.9 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.21 001009293.1_39524001_1 - 0.044 13.6 0.0 0.078 12.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Toxin_1 PF00087.19 001009293.1_39524001_1 - 1.8 8.7 12.1 5.9 7.1 12.1 1.9 1 1 0 1 1 1 0 Snake toxin Galactosyl_T PF01762.19 214327.1_49827001_1 - 1.6e-46 158.5 0.0 2.4e-46 157.9 0.0 1.3 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.14 214327.1_49827001_1 - 0.0043 16.4 0.0 0.0065 15.8 0.0 1.3 1 0 0 1 1 1 1 Fringe-like TNF PF00229.16 001009298.1_22422001_2 - 4.8e-30 104.0 0.1 1.3e-29 102.5 0.0 1.7 2 0 0 2 2 2 1 TNF(Tumour Necrosis Factor) family Mit_ribos_Mrp51 PF11709.6 001009298.1_22422001_2 - 0.13 11.7 0.1 0.15 11.5 0.1 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit TMEM135_C_rich PF15982.3 001013896.1_45727001_1 - 2e-71 238.6 1.0 2e-71 238.6 1.0 2.0 2 0 0 2 2 2 1 N-terminal cysteine-rich region of Transmembrane protein 135 Tim17 PF02466.17 001013896.1_45727001_1 - 2.1e-09 37.5 0.2 3.8e-07 30.3 0.1 2.5 2 0 0 2 2 2 2 Tim17/Tim22/Tim23/Pmp24 family C1q PF00386.19 019262.1_45723001_2 - 1.2e-31 109.4 0.1 1.6e-31 109.0 0.1 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.16 019262.1_45723001_2 - 3.7e-15 55.3 52.3 1.3e-09 37.5 16.4 2.4 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Cystatin PF00031.19 213859.1_49822001_3 - 1.1e-24 86.3 0.6 1.7e-24 85.8 0.6 1.3 1 0 0 1 1 1 1 Cystatin domain Dynein_light PF01221.16 213859.1_49822001_3 - 0.063 13.5 1.3 0.2 11.8 0.0 2.0 2 0 0 2 2 2 0 Dynein light chain type 1 IL7 PF01415.14 214135.2_49822001_2 - 8e-49 165.0 4.0 1.1e-48 164.6 4.0 1.1 1 0 0 1 1 1 1 Interleukin 7/9 family DUF4639 PF15479.4 001024330.1_45724001_1 - 9e-258 856.9 21.1 1e-257 856.7 21.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4639) Hormone_2 PF00123.18 214324.1_49822001_1 - 6.2e-44 147.5 2.5 2.1e-15 56.2 0.3 3.2 3 0 0 3 3 3 3 Peptide hormone Lipoprotein_10 PF03202.11 214324.1_49822001_1 - 8.8e-05 22.8 3.7 0.37 11.1 0.1 3.2 2 1 1 3 3 3 2 Putative mycoplasma lipoprotein, C-terminal region HnRNPA1 PF11627.6 001009728.2_39524001_2 - 1.3e-14 53.8 6.5 1.3e-14 53.8 6.5 1.8 2 0 0 2 2 2 1 Nuclear factor hnRNPA1 Lectin_C PF00059.19 001009728.2_39524001_3 - 2e-21 76.6 0.0 3.7e-21 75.7 0.0 1.5 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 001009728.2_39524001_3 - 1.1e-10 41.0 35.3 8.1e-05 22.2 15.2 2.5 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Guanylate_cyc PF00211.18 130737.4_45728001_2 - 2.5e-63 212.9 0.0 5.5e-63 211.8 0.0 1.6 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain ANF_receptor PF01094.26 130737.4_45728001_2 - 1.7e-58 198.3 0.0 2.4e-58 197.8 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Pkinase_Tyr PF07714.15 130737.4_45728001_2 - 2e-33 115.6 0.0 2.9e-33 115.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 130737.4_45728001_2 - 2.8e-27 95.6 0.0 4.3e-27 95.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain HNOBA PF07701.12 130737.4_45728001_2 - 8e-05 22.0 0.9 0.00013 21.4 0.9 1.3 1 0 0 1 1 1 1 Heme NO binding associated Kinase-like PF14531.4 130737.4_45728001_2 - 0.058 12.6 0.0 0.095 11.9 0.0 1.2 1 0 0 1 1 1 0 Kinase-like LSM PF01423.20 001032995.1_32322001_2 - 0.03 13.9 0.0 0.043 13.4 0.0 1.2 1 0 0 1 1 1 0 LSM domain LSM PF01423.20 001032995.1_32322001_3 - 4.5e-12 45.4 0.0 6.6e-12 44.8 0.0 1.2 1 0 0 1 1 1 1 LSM domain DUF4701 PF15773.3 001014115.1_45724001_1 - 5.1e-183 609.5 27.8 6.4e-183 609.2 27.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4701) 7tm_1 PF00001.19 001012438.1_39724001_1 - 7.4e-45 153.1 18.8 9.2e-45 152.8 18.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001012438.1_39724001_1 - 9.7e-09 34.8 16.3 1.3e-08 34.5 16.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001012438.1_39724001_1 - 0.00039 19.7 8.7 0.00039 19.7 8.7 2.2 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.4 001012438.1_39724001_1 - 0.37 10.3 15.5 1.8 8.1 15.5 1.9 1 1 0 1 1 1 0 Olfactory receptor VKG_Carbox PF05090.12 001009750.1_39525001_1 - 1.4e-171 571.0 8.7 1.7e-171 570.8 8.7 1.1 1 0 0 1 1 1 1 Vitamin K-dependent gamma-carboxylase Cupin_2 PF07883.9 001009750.1_39525001_1 - 0.023 14.3 0.0 0.059 13.0 0.0 1.6 1 0 0 1 1 1 0 Cupin domain DoxX PF07681.10 001009750.1_39525001_1 - 2.6 8.6 6.5 1.5 9.4 2.1 2.6 2 1 0 2 2 2 0 DoxX Adipogenin PF15202.4 001009750.1_39525001_1 - 8.4 6.4 7.9 0.56 10.1 1.5 2.3 2 0 0 2 2 2 0 Adipogenin Cystatin PF00031.19 001009095.1_39721001_1 - 1.8e-23 82.5 0.6 2e-23 82.3 0.6 1.0 1 0 0 1 1 1 1 Cystatin domain Dynein_light PF01221.16 001009095.1_39721001_1 - 0.012 15.7 0.0 0.016 15.3 0.0 1.2 1 0 0 1 1 1 0 Dynein light chain type 1 SQAPI PF16845.3 001009095.1_39721001_1 - 0.016 15.4 0.1 0.022 15.0 0.1 1.3 1 0 0 1 1 1 0 Aspartic acid proteinase inhibitor Peptidase_C14 PF00656.20 001009365.1_22423001_1 - 9.6e-52 176.3 0.1 2.4e-51 174.9 0.0 1.6 2 0 0 2 2 2 1 Caspase domain CARD PF00619.19 001009365.1_22423001_1 - 6.7e-29 99.6 0.1 1.4e-28 98.6 0.1 1.6 1 0 0 1 1 1 1 Caspase recruitment domain DUF1338 PF07063.11 001009365.1_22423001_1 - 0.003 16.6 0.0 0.0048 16.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1338) Lectin_C PF00059.19 001009062.1_39722001_2 - 3e-16 60.0 5.1 3e-16 60.0 5.1 1.9 2 0 0 2 2 2 1 Lectin C-type domain Chordopox_A33R PF05966.10 001009062.1_39722001_2 - 0.016 14.3 0.2 0.021 13.9 0.2 1.3 1 0 0 1 1 1 0 Chordopoxvirus A33R protein Ly49 PF08391.8 001009062.1_39722001_2 - 0.18 12.0 0.2 0.18 12.0 0.2 3.1 3 1 0 3 3 3 0 Ly49-like protein, N-terminal region AAA PF00004.27 214280.1_49827001_2 - 2.7e-96 318.9 0.0 6.5e-47 159.1 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.16 214280.1_49827001_2 - 2.2e-21 75.7 0.2 8.6e-21 73.8 0.2 2.1 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.10 214280.1_49827001_2 - 4.5e-13 48.9 0.0 2.4e-05 23.6 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.4 214280.1_49827001_2 - 8.3e-13 48.9 4.8 5.1e-05 23.6 0.1 4.7 4 2 1 5 5 4 2 AAA ATPase domain CDC48_2 PF02933.15 214280.1_49827001_2 - 1.7e-12 46.8 0.0 3.5e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_33 PF13671.4 214280.1_49827001_2 - 2.3e-10 40.7 0.0 8e-05 22.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.12 214280.1_49827001_2 - 3.1e-10 40.3 0.0 5.1e-05 23.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.12 214280.1_49827001_2 - 3.8e-10 39.8 0.1 6.3e-05 22.9 0.0 3.1 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.4 214280.1_49827001_2 - 5e-09 36.4 0.7 0.018 15.2 0.1 4.0 3 2 0 3 3 2 2 AAA domain Vps4_C PF09336.8 214280.1_49827001_2 - 1.6e-08 34.3 1.0 4.2e-05 23.3 0.1 2.6 2 0 0 2 2 2 2 Vps4 C terminal oligomerisation domain TIP49 PF06068.11 214280.1_49827001_2 - 1.7e-08 33.7 0.0 0.0014 17.5 0.0 2.5 2 0 0 2 2 2 2 TIP49 C-terminus AAA_18 PF13238.4 214280.1_49827001_2 - 3.2e-07 30.8 0.0 0.029 14.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.20 214280.1_49827001_2 - 4.1e-07 30.2 0.0 0.0083 16.4 0.0 2.9 3 0 0 3 3 2 2 RNA helicase Mg_chelatase PF01078.19 214280.1_49827001_2 - 6e-07 28.9 0.1 0.023 13.9 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.15 214280.1_49827001_2 - 6.9e-07 29.1 0.1 0.052 13.2 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_14 PF13173.4 214280.1_49827001_2 - 9.8e-07 28.7 0.0 0.031 14.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain Parvo_NS1 PF01057.15 214280.1_49827001_2 - 5.8e-06 25.5 0.1 0.043 12.8 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_28 PF13521.4 214280.1_49827001_2 - 9.8e-06 25.8 0.0 0.24 11.5 0.0 2.9 3 0 0 3 3 2 2 AAA domain ATPase PF06745.11 214280.1_49827001_2 - 1.5e-05 24.4 0.1 0.6 9.3 0.0 3.3 3 0 0 3 3 3 2 KaiC ATPase_2 PF01637.16 214280.1_49827001_2 - 1.8e-05 24.6 0.2 0.31 10.8 0.0 3.6 2 2 0 2 2 2 2 ATPase domain predominantly from Archaea Bac_DnaA PF00308.16 214280.1_49827001_2 - 2e-05 24.4 0.0 0.11 12.1 0.0 2.9 3 0 0 3 3 2 2 Bacterial dnaA protein ABC_tran PF00005.25 214280.1_49827001_2 - 2.1e-05 24.9 0.1 0.014 15.8 0.0 3.3 2 1 0 2 2 2 1 ABC transporter AAA_25 PF13481.4 214280.1_49827001_2 - 2.9e-05 23.6 2.0 2.2 7.7 0.0 3.5 2 2 0 3 3 3 1 AAA domain DUF815 PF05673.11 214280.1_49827001_2 - 3.4e-05 23.0 0.0 0.019 14.0 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_24 PF13479.4 214280.1_49827001_2 - 8.5e-05 22.2 0.1 0.11 12.1 0.0 2.6 2 1 0 2 2 2 2 AAA domain TsaE PF02367.15 214280.1_49827001_2 - 0.00013 21.8 0.0 0.41 10.5 0.0 2.3 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Viral_helicase1 PF01443.16 214280.1_49827001_2 - 0.00014 21.5 0.0 0.0024 17.5 0.0 2.6 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.24 214280.1_49827001_2 - 0.00021 20.9 0.0 0.58 9.7 0.0 2.7 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_17 PF13207.4 214280.1_49827001_2 - 0.00026 21.3 0.1 1.4 9.2 0.0 3.0 3 0 0 3 3 2 2 AAA domain NACHT PF05729.10 214280.1_49827001_2 - 0.00033 20.5 0.1 0.39 10.5 0.0 3.3 3 1 1 4 4 4 1 NACHT domain Zeta_toxin PF06414.10 214280.1_49827001_2 - 0.00098 18.3 0.0 0.53 9.4 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin NB-ARC PF00931.20 214280.1_49827001_2 - 0.0011 17.9 0.0 0.3 9.9 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain DUF2075 PF09848.7 214280.1_49827001_2 - 0.0014 17.9 0.0 0.5 9.4 0.0 2.5 3 0 0 3 3 2 1 Uncharacterized conserved protein (DUF2075) AAA_3 PF07726.9 214280.1_49827001_2 - 0.0014 18.3 0.0 2 8.2 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ResIII PF04851.13 214280.1_49827001_2 - 0.0015 18.4 0.0 0.11 12.4 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PhoH PF02562.14 214280.1_49827001_2 - 0.0023 17.3 0.5 2.2 7.5 0.1 2.4 2 0 0 2 2 2 2 PhoH-like protein Sigma54_activ_2 PF14532.4 214280.1_49827001_2 - 0.0027 17.7 0.0 3.2 7.7 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain TniB PF05621.9 214280.1_49827001_2 - 0.0036 16.4 0.2 12 4.8 0.1 4.2 4 0 0 4 4 4 0 Bacterial TniB protein AAA_11 PF13086.4 214280.1_49827001_2 - 0.0048 16.5 0.0 2.8 7.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.4 214280.1_49827001_2 - 0.005 17.1 0.4 3.8 7.7 0.2 3.0 2 1 0 2 2 2 0 AAA domain AAA_30 PF13604.4 214280.1_49827001_2 - 0.035 13.7 0.4 3.7 7.1 0.1 2.6 2 0 0 2 2 2 0 AAA domain SKI PF01202.20 214280.1_49827001_2 - 0.06 13.3 0.0 7.2 6.6 0.0 2.7 2 0 0 2 2 2 0 Shikimate kinase NTPase_1 PF03266.13 214280.1_49827001_2 - 0.075 12.8 0.2 6.6 6.5 0.0 2.9 3 0 0 3 3 2 0 NTPase Cytidylate_kin PF02224.16 214280.1_49827001_2 - 0.087 12.4 0.0 12 5.5 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase UFD1 PF03152.12 214280.1_49827001_2 - 0.091 12.1 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin fusion degradation protein UFD1 DUF3944 PF13099.4 214280.1_49827001_2 - 0.12 12.1 0.0 0.39 10.5 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3944) LRR_9 PF14580.4 001014089.1_45724001_3 - 3.4e-14 52.6 1.1 5.1e-10 39.0 0.0 3.3 2 1 1 3 3 3 3 Leucine-rich repeat LRR_4 PF12799.5 001014089.1_45724001_3 - 1.3e-06 28.4 22.0 0.0043 17.3 2.2 5.5 1 1 4 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001014089.1_45724001_3 - 2.2e-06 27.2 12.4 0.013 15.2 0.4 4.1 2 2 0 3 3 3 3 Leucine rich repeat Ubiquitin_2 PF14560.4 001014089.1_45724001_3 - 2.8e-06 27.5 0.1 8.2e-06 26.0 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin-like domain LRR_1 PF00560.31 001014089.1_45724001_3 - 0.66 10.5 8.0 5.4 7.8 0.1 4.6 4 1 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.4 001014089.1_45724001_3 - 8.6 6.6 15.8 1 9.5 0.1 4.1 5 0 0 5 5 5 0 Leucine Rich repeat Creatinase_N_2 PF16189.3 057155.3_45726001_3 - 2.6e-44 151.0 0.0 6.6e-43 146.4 0.0 2.4 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.22 057155.3_45726001_3 - 3.8e-37 127.9 0.0 5.7e-37 127.3 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.3 057155.3_45726001_3 - 1.1e-19 70.1 0.4 3e-19 68.7 0.4 1.8 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.16 057155.3_45726001_3 - 1.6e-18 67.5 0.0 6.5e-18 65.5 0.0 1.9 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Pkinase_Tyr PF07714.15 001034166.1_39728001_2 - 7.7e-36 123.6 0.0 1.4e-35 122.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001034166.1_39728001_2 - 1.2e-35 123.1 0.0 3.6e-35 121.5 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.12 001034166.1_39728001_2 - 0.0023 17.2 0.1 0.006 15.8 0.1 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 001034166.1_39728001_2 - 0.0026 17.0 0.0 0.0065 15.7 0.0 1.6 1 0 0 1 1 1 1 Kinase-like APH PF01636.21 001034166.1_39728001_2 - 0.052 13.3 1.0 0.44 10.3 0.0 2.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family Ank_2 PF12796.5 031805.1_45729001_2 - 6.6e-146 475.2 47.8 2.3e-17 63.2 0.1 11.8 2 2 9 11 11 11 11 Ankyrin repeats (3 copies) Ank PF00023.28 031805.1_45729001_2 - 2.1e-136 438.9 65.0 6.2e-07 29.5 0.0 23.3 22 1 1 23 23 23 21 Ankyrin repeat Ank_4 PF13637.4 031805.1_45729001_2 - 6e-121 393.3 52.4 4.9e-11 42.8 0.5 17.0 5 3 12 18 18 18 18 Ankyrin repeats (many copies) Ank_5 PF13857.4 031805.1_45729001_2 - 2.2e-114 371.4 45.7 4.5e-12 45.8 0.0 16.7 3 3 15 19 19 19 18 Ankyrin repeats (many copies) Ank_3 PF13606.4 031805.1_45729001_2 - 1.7e-109 344.2 36.6 0.00014 21.9 0.0 24.1 24 0 0 24 24 24 21 Ankyrin repeat ZU5 PF00791.18 031805.1_45729001_2 - 2.3e-33 114.3 0.9 4.2e-27 94.2 0.0 2.6 2 0 0 2 2 2 2 ZU5 domain Death PF00531.20 031805.1_45729001_2 - 2.7e-21 75.4 0.0 5.7e-21 74.4 0.0 1.6 1 0 0 1 1 1 1 Death domain PK_C PF02887.14 031805.1_45729001_2 - 0.01 15.9 1.8 21 5.3 0.0 4.8 5 1 0 5 5 5 0 Pyruvate kinase, alpha/beta domain Asp_protease_2 PF13650.4 031805.1_45729001_2 - 0.12 12.9 0.3 3.3 8.3 0.1 3.2 3 0 0 3 3 3 0 Aspartyl protease IlvN PF07991.10 031805.1_45729001_2 - 0.87 9.0 3.2 6.2 6.2 0.4 3.3 3 0 0 3 3 3 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Lipocalin PF00061.21 013015.2_45722001_2 - 2e-35 121.9 0.0 2.4e-35 121.7 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Triabin PF03973.11 013015.2_45722001_2 - 0.00018 21.2 0.0 0.00032 20.5 0.0 1.3 1 0 0 1 1 1 1 Triabin Perilipin PF03036.14 214200.2_49824001_1 - 7.7e-163 542.0 11.6 9.2e-163 541.7 11.6 1.1 1 0 0 1 1 1 1 Perilipin family SH3BP5 PF05276.12 214200.2_49824001_1 - 0.022 14.5 2.9 0.026 14.2 0.9 2.0 2 0 0 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) Snapin_Pallidin PF14712.4 214200.2_49824001_1 - 0.033 14.5 2.6 1.2 9.5 1.0 2.9 2 0 0 2 2 2 0 Snapin/Pallidin Apolipoprotein PF01442.16 214200.2_49824001_1 - 0.063 13.1 4.4 3 7.6 0.1 2.8 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain USP19_linker PF16602.3 214200.2_49824001_1 - 0.14 12.5 1.7 0.39 11.1 1.7 1.7 1 0 0 1 1 1 0 Linker region of USP19 deubiquitinase HSP9_HSP12 PF04119.10 214200.2_49824001_1 - 0.17 12.1 4.0 6.5 7.1 0.1 3.6 2 1 1 3 3 3 0 Heat shock protein 9/12 EPTP PF03736.15 001071778.1_39724001_1 - 1.6e-69 229.5 21.9 1.3e-12 47.4 0.1 7.5 7 1 0 7 7 7 7 EPTP domain LRR_8 PF13855.4 001071778.1_39724001_1 - 1.4e-22 79.1 12.5 1.7e-15 56.3 5.1 2.6 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.5 001071778.1_39724001_1 - 3.4e-09 36.7 9.4 0.00017 21.7 3.5 2.8 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001071778.1_39724001_1 - 1.8e-07 31.0 1.5 1.8e-07 31.0 1.5 2.3 2 0 0 2 2 2 1 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001071778.1_39724001_1 - 0.00045 19.6 2.2 0.024 14.0 0.2 1.7 1 1 1 2 2 2 2 Leucine-rich repeat LRRCT PF01463.22 001071778.1_39724001_1 - 0.071 13.6 0.0 0.45 11.1 0.0 2.3 2 0 0 2 2 2 0 Leucine rich repeat C-terminal domain LRR_1 PF00560.31 001071778.1_39724001_1 - 1 9.9 11.2 2.5 8.8 0.5 4.4 4 0 0 4 4 4 0 Leucine Rich Repeat Cadherin PF00028.15 001035535.1_49827001_1 - 1.4e-54 182.4 1.7 9.4e-20 70.7 0.0 5.4 5 0 0 5 5 5 4 Cadherin domain Cadherin_C PF01049.15 001035535.1_49827001_1 - 1.2e-08 35.2 0.0 2.4e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_3 PF16184.3 001035535.1_49827001_1 - 4.2e-05 23.4 0.8 0.022 14.6 0.1 2.9 3 0 0 3 3 3 2 Cadherin-like Cadherin_2 PF08266.10 001035535.1_49827001_1 - 0.0056 16.3 0.0 3.8 7.3 0.0 3.4 3 0 0 3 3 3 1 Cadherin-like SNF PF00209.16 001082350.1_37925001_3 - 2.8e-238 791.7 38.7 3.3e-238 791.5 38.7 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family ISK_Channel PF02060.13 001109822.1_37923001_2 - 1.6e-56 189.1 0.0 2.1e-56 188.7 0.0 1.1 1 0 0 1 1 1 1 Slow voltage-gated potassium channel Globin PF00042.20 001082389.2_37922001_1 - 1.6e-26 92.9 0.1 2.3e-26 92.4 0.1 1.2 1 0 0 1 1 1 1 Globin W2 PF02020.16 001082674.1_37926001_3 - 1.8e-19 69.5 2.2 6.8e-19 67.7 2.2 2.1 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.22 001082674.1_37926001_3 - 3e-09 36.1 7.5 0.00026 20.5 6.0 4.0 2 1 2 4 4 4 3 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.3 001082674.1_37926001_3 - 0.0038 15.3 0.3 0.0057 14.7 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Fucokinase PF07959.10 001082674.1_37926001_3 - 0.0094 14.9 0.4 0.016 14.1 0.4 1.3 1 0 0 1 1 1 1 L-fucokinase PRY PF13765.4 001114946.1_29623001_1 - 2.5e-17 62.1 0.0 4.6e-17 61.2 0.0 1.5 1 0 0 1 1 1 1 SPRY-associated domain zf-C3HC4_4 PF15227.4 001114946.1_29623001_1 - 1.8e-07 31.1 8.7 3.5e-07 30.1 8.7 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001114946.1_29623001_1 - 1.7e-06 27.7 6.5 3e-06 26.9 6.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001114946.1_29623001_1 - 1.2e-05 25.1 8.9 2.4e-05 24.1 8.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 001114946.1_29623001_1 - 3.1e-05 23.6 9.6 0.00012 21.8 9.6 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001114946.1_29623001_1 - 6.1e-05 23.1 8.0 0.00014 22.0 8.0 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.4 001114946.1_29623001_1 - 6.3e-05 22.7 5.0 0.00017 21.3 5.1 1.7 1 1 0 1 1 1 1 zinc-RING finger domain SPRY PF00622.26 001114946.1_29623001_1 - 0.00013 21.9 0.0 0.0002 21.3 0.0 1.2 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_3 PF13920.4 001114946.1_29623001_1 - 0.0018 17.9 8.2 0.0035 17.0 8.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 001114946.1_29623001_1 - 0.0066 16.2 5.1 0.018 14.7 5.1 1.8 1 1 0 1 1 1 1 zf-RING of BARD1-type protein zf-4CXXC_R1 PF10497.7 001114946.1_29623001_1 - 0.077 13.1 3.0 0.17 12.0 3.0 1.5 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 Prok-RING_4 PF14447.4 001114946.1_29623001_1 - 0.2 11.4 11.2 1.3 8.8 11.5 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Globin PF00042.20 001042627.1_39722001_2 - 1.5e-28 99.4 0.2 2.2e-28 98.9 0.2 1.2 1 0 0 1 1 1 1 Globin Globin PF00042.20 001044724.1_29621001_1 - 4.5e-28 97.9 0.1 6.6e-28 97.3 0.1 1.2 1 0 0 1 1 1 1 Globin EPTP PF03736.15 001044378.1_39724001_1 - 5.5e-73 240.6 21.6 5.2e-14 51.8 0.2 7.3 7 0 0 7 7 7 7 EPTP domain LRR_8 PF13855.4 001044378.1_39724001_1 - 4e-24 84.0 9.7 3.7e-14 52.1 1.2 2.9 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.5 001044378.1_39724001_1 - 9.2e-09 35.3 2.7 0.00032 20.9 0.3 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.4 001044378.1_39724001_1 - 1.2e-08 34.9 0.7 3.3e-08 33.4 0.1 2.1 2 0 0 2 2 2 1 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001044378.1_39724001_1 - 0.0012 18.3 0.2 0.076 12.4 0.0 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.31 001044378.1_39724001_1 - 0.0042 17.2 5.0 14 6.5 0.0 4.9 4 0 0 4 4 4 1 Leucine Rich Repeat SUKH_5 PF14567.4 001044378.1_39724001_1 - 0.088 12.4 5.0 4.6 6.9 0.4 3.2 3 0 0 3 3 3 0 SMI1-KNR4 cell-wall LRR_6 PF13516.4 001044378.1_39724001_1 - 0.15 12.1 0.6 28 5.0 0.1 3.5 3 0 0 3 3 3 0 Leucine Rich repeat Mito_carr PF00153.25 001127275.1_39522001_1 - 7e-59 195.6 6.2 1.6e-21 75.9 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein TRAPP PF04051.14 001127275.1_39522001_1 - 0.017 14.7 0.0 4.2 6.9 0.0 2.2 2 0 0 2 2 2 0 Transport protein particle (TRAPP) component HTH_21 PF13276.4 001127275.1_39522001_1 - 0.25 11.4 2.2 0.3 11.1 0.1 2.2 2 0 0 2 2 2 0 HTH-like domain ThrE_2 PF12821.5 001127275.1_39522001_1 - 0.51 10.3 6.2 2.8 7.9 0.2 3.7 3 1 1 4 4 4 0 Threonine/Serine exporter, ThrE PMI_typeI PF01238.19 001098550.1_39724001_3 - 6.1e-151 502.7 0.0 7.5e-151 502.4 0.0 1.1 1 0 0 1 1 1 1 Phosphomannose isomerase type I SAM_1 PF00536.28 001114164.1_39722001_1 - 2.7e-17 62.8 0.0 4.6e-17 62.1 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.15 001114164.1_39722001_1 - 6.7e-06 26.0 0.0 1.3e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 001114164.1_39722001_1 - 0.0043 16.8 0.0 0.03 14.1 0.0 2.1 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain Glyco_hydro_56 PF01630.16 001082672.1_37925001_3 - 2.9e-132 440.6 0.0 3.6e-132 440.3 0.0 1.1 1 0 0 1 1 1 1 Hyaluronidase TNF PF00229.16 001047150.1_29622001_1 - 3.7e-34 117.3 0.0 4.7e-34 116.9 0.0 1.1 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family Lectin_C PF00059.19 001071787.1_39723001_1 - 1.5e-24 86.6 6.0 3.1e-24 85.7 6.0 1.5 1 0 0 1 1 1 1 Lectin C-type domain DUF2730 PF10805.6 001071787.1_39723001_1 - 1.5e-11 44.1 19.2 0.018 15.0 1.1 5.2 1 1 8 9 9 9 8 Protein of unknown function (DUF2730) DUF2170 PF09938.7 001071787.1_39723001_1 - 8.8e-11 41.5 5.6 0.54 9.8 0.2 7.8 1 1 8 9 9 9 1 Uncharacterized protein conserved in bacteria (DUF2170) Reo_sigmaC PF04582.10 001071787.1_39723001_1 - 1.3e-08 34.5 5.6 0.019 14.2 0.6 3.4 1 1 3 4 4 4 4 Reovirus sigma C capsid protein Telethonin PF09470.8 001071787.1_39723001_1 - 5e-06 26.4 3.1 3.5 7.4 0.1 4.9 1 1 5 6 6 6 1 Telethonin protein Occludin_ELL PF07303.11 001071787.1_39723001_1 - 1.2e-05 25.8 23.1 0.084 13.4 3.3 4.7 1 1 3 5 5 5 3 Occludin homology domain CHASE5 PF17149.2 001071787.1_39723001_1 - 1.2e-05 25.0 4.1 24 4.8 0.0 6.8 3 2 3 7 7 7 0 Periplasmic sensor domain found in signal transduction proteins DUF2408 PF10303.7 001071787.1_39723001_1 - 4e-05 24.1 32.4 11 6.5 0.2 8.8 2 1 3 6 6 6 0 Protein of unknown function (DUF2408) Vps5 PF09325.8 001071787.1_39723001_1 - 4.7e-05 22.9 19.7 0.068 12.6 4.4 3.2 1 1 2 3 3 3 3 Vps5 C terminal like DUF4763 PF15960.3 001071787.1_39723001_1 - 0.00028 20.1 37.1 1.2 8.3 1.9 7.0 1 1 7 8 8 8 2 Domain of unknown function (DUF4763) Mhr1 PF12829.5 001071787.1_39723001_1 - 0.0004 20.3 13.9 66 3.6 0.0 8.8 1 1 9 10 10 10 0 Transcriptional regulation of mitochondrial recombination DUF617 PF04759.11 001071787.1_39723001_1 - 0.00062 19.8 0.1 8.3 6.3 0.0 4.3 1 1 5 6 6 6 0 Protein of unknown function, DUF617 DIMCO_N PF16844.3 001071787.1_39723001_1 - 0.0013 18.8 17.2 1.4 9.2 1.4 3.9 1 1 5 6 6 6 3 Dinitrogenase iron-molybdenum cofactor, N-terminal Syntaxin_2 PF14523.4 001071787.1_39723001_1 - 0.0015 18.8 13.0 6.1e+03 -2.5 13.7 4.9 1 1 0 1 1 0 0 Syntaxin-like protein DUF4665 PF15679.3 001071787.1_39723001_1 - 0.0029 18.1 12.6 1.3 9.6 0.5 4.0 1 1 3 4 4 4 2 Domain of unknown function (DUF4665) YceG PF02618.14 001071787.1_39723001_1 - 0.0048 16.4 12.6 0.23 10.9 1.9 3.0 1 1 2 3 3 3 3 YceG-like family tRNA-synt_His PF13393.4 001071787.1_39723001_1 - 0.0053 15.9 18.0 0.88 8.6 2.0 3.8 1 1 5 6 6 6 2 Histidyl-tRNA synthetase RP-C_C PF11800.6 001071787.1_39723001_1 - 0.0064 16.4 15.8 4.9 7.0 7.8 5.3 1 1 3 4 4 4 0 Replication protein C C-terminal region Com_YlbF PF06133.9 001071787.1_39723001_1 - 0.0064 16.9 32.8 1.4 9.4 15.6 3.3 1 1 1 2 2 2 1 Control of competence regulator ComK, YlbF/YmcA CREPT PF16566.3 001071787.1_39723001_1 - 0.0071 16.4 18.8 3.9 7.5 0.7 4.8 1 1 6 7 7 7 0 Cell-cycle alteration and expression-elevated protein in tumour HBM PF16591.3 001071787.1_39723001_1 - 0.014 14.7 24.8 0.056 12.7 7.4 2.5 1 1 1 2 2 2 0 Helical bimodular sensor domain DUF4363 PF14276.4 001071787.1_39723001_1 - 0.024 14.5 15.6 1.2 9.1 2.4 3.9 2 1 3 5 5 4 0 Domain of unknown function (DUF4363) BLOC1_2 PF10046.7 001071787.1_39723001_1 - 0.033 14.4 31.1 2.6 8.3 2.2 6.2 1 1 5 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Cep57_CLD_2 PF14197.4 001071787.1_39723001_1 - 0.034 14.1 31.5 17 5.5 0.7 8.5 1 1 6 7 7 7 0 Centrosome localisation domain of PPC89 Cytochrom_B562 PF07361.9 001071787.1_39723001_1 - 0.038 14.5 13.4 1.2e+03 0.1 12.7 4.5 1 1 0 1 1 1 0 Cytochrome b562 UL45 PF05473.10 001071787.1_39723001_1 - 0.054 13.0 1.8 0.12 11.9 0.6 2.1 2 0 0 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like VPS28 PF03997.10 001071787.1_39723001_1 - 0.06 12.9 13.2 11 5.6 0.6 4.3 1 1 5 6 6 6 0 VPS28 protein HsbA PF12296.6 001071787.1_39723001_1 - 0.064 13.6 5.7 89 3.4 0.1 5.1 1 1 4 6 6 6 0 Hydrophobic surface binding protein A DUF972 PF06156.11 001071787.1_39723001_1 - 0.1 13.1 24.8 66 4.1 7.3 5.1 1 1 1 2 2 1 0 Protein of unknown function (DUF972) Med10 PF09748.7 001071787.1_39723001_1 - 0.19 11.6 22.1 1.3e+02 2.4 8.2 4.8 1 1 1 2 2 1 0 Transcription factor subunit Med10 of Mediator complex DUF3422 PF11902.6 001071787.1_39723001_1 - 0.23 10.4 23.4 1.1 8.1 0.3 4.7 1 1 7 8 8 8 0 Protein of unknown function (DUF3422) DUF4795 PF16043.3 001071787.1_39723001_1 - 0.23 10.9 23.2 94 2.4 23.2 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) COMP PF11598.6 001071787.1_39723001_1 - 0.29 11.5 22.6 27 5.2 0.4 6.8 1 1 8 9 9 9 0 Cartilage oligomeric matrix protein HARE-HTH PF05066.11 001071787.1_39723001_1 - 0.56 10.5 0.0 0.56 10.5 0.0 3.5 3 1 4 7 7 3 0 HB1, ASXL, restriction endonuclease HTH domain DUF1269 PF06897.10 001071787.1_39723001_1 - 0.74 10.0 8.6 81 3.5 0.2 4.1 1 1 3 5 5 5 0 Protein of unknown function (DUF1269) DUF3347 PF11827.6 001071787.1_39723001_1 - 0.88 9.6 16.3 2.8 8.0 5.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3347) NYD-SP28 PF14772.4 001071787.1_39723001_1 - 0.95 9.4 30.5 7.5 6.5 3.9 6.2 1 1 5 6 6 6 0 Sperm tail Plasmid_RAQPRD PF09686.8 001071787.1_39723001_1 - 1.2 9.3 38.1 4 7.6 0.7 8.4 1 1 8 9 9 9 0 Plasmid protein of unknown function (Plasmid_RAQPRD) MalF_P2 PF14785.4 001071787.1_39723001_1 - 1.5 8.7 14.8 19 5.1 2.4 4.0 1 1 3 4 4 4 0 Maltose transport system permease protein MalF P2 domain Suf PF05843.12 001071787.1_39723001_1 - 1.8 8.3 9.3 1.4e+02 2.2 9.3 3.0 1 1 0 1 1 1 0 Suppressor of forked protein (Suf) EF-hand_3 PF09069.9 001071787.1_39723001_1 - 2.2 8.6 13.1 88 3.5 0.2 5.5 2 1 6 8 8 7 0 EF-hand P53_C PF11619.6 001071787.1_39723001_1 - 3.1 7.8 13.5 65 3.6 0.1 5.7 1 1 8 9 9 9 0 Transcription factor P53 - C terminal domain FUSC PF04632.10 001071787.1_39723001_1 - 3.5 5.9 9.5 1.3e+02 0.8 9.4 2.2 1 1 0 1 1 1 0 Fusaric acid resistance protein family PCRF PF03462.16 001071787.1_39723001_1 - 4.6 6.9 23.9 1.6e+04 -9.1 23.9 3.3 1 1 0 1 1 0 0 PCRF domain DUF2203 PF09969.7 001071787.1_39723001_1 - 7.5 7.2 21.1 35 5.0 2.1 4.0 1 1 1 2 2 1 0 Uncharacterized conserved protein (DUF2203) DUF641 PF04859.10 001071787.1_39723001_1 - 8.4 6.6 18.7 12 6.1 1.5 3.6 1 1 1 2 2 1 0 Plant protein of unknown function (DUF641) AKNA PF12443.6 001071787.1_39723001_1 - 8.4 7.0 29.7 5.7 7.5 5.2 5.4 1 1 4 5 5 5 0 AT-hook-containing transcription factor Oxysterol_BP PF01237.16 001082233.1_37928001_3 - 2.5e-146 487.1 0.5 4.9e-146 486.2 0.5 1.5 1 0 0 1 1 1 1 Oxysterol-binding protein PH PF00169.27 001082233.1_37928001_3 - 1.2e-15 57.8 0.1 2.9e-15 56.5 0.1 1.6 1 0 0 1 1 1 1 PH domain PH_8 PF15409.4 001082233.1_37928001_3 - 1.6e-11 44.2 0.3 3.2e-11 43.2 0.3 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.4 001082233.1_37928001_3 - 3e-05 24.1 0.0 0.0001 22.4 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.4 001082233.1_37928001_3 - 5.8e-05 23.3 4.0 0.0043 17.3 4.0 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain Syntaxin-6_N PF09177.9 001082233.1_37928001_3 - 0.21 12.0 4.8 0.32 11.5 1.8 2.5 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Pro_isomerase PF00160.19 001082057.1_37922001_3 - 5.6e-47 159.8 0.2 6.5e-47 159.6 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Alk_phosphatase PF00245.18 001042563.1_22425001_1 - 3.8e-180 599.1 0.6 4.6e-180 598.9 0.6 1.1 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.16 001042563.1_22425001_1 - 0.002 17.4 0.0 0.0036 16.6 0.0 1.5 1 1 0 1 1 1 1 Metalloenzyme superfamily Calsarcin PF05556.9 001025222.2_49823001_2 - 3.5e-102 340.9 0.0 4.1e-102 340.6 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-binding protein (Calsarcin) Pkinase PF00069.23 001082006.1_37923001_1 - 2.6e-72 243.2 0.0 3.7e-72 242.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001082006.1_37923001_1 - 9.1e-36 123.3 0.0 1.4e-35 122.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001082006.1_37923001_1 - 0.00091 18.5 0.0 0.0013 18.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 001082006.1_37923001_1 - 0.0012 18.1 0.1 0.002 17.4 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.20 001082006.1_37923001_1 - 0.015 14.8 0.1 0.026 14.0 0.1 1.4 1 0 0 1 1 1 0 RIO1 family APH PF01636.21 001082006.1_37923001_1 - 0.12 12.2 0.1 0.2 11.4 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Tetraspannin PF00335.18 001042568.1_22423001_1 - 1.4e-25 90.3 4.7 1.8e-25 89.9 4.7 1.1 1 0 0 1 1 1 1 Tetraspanin family LtrA PF06772.9 001042568.1_22423001_1 - 0.066 12.3 0.1 0.1 11.6 0.1 1.2 1 0 0 1 1 1 0 Bacterial low temperature requirement A protein (LtrA) SLAC1 PF03595.15 001042568.1_22423001_1 - 0.67 9.1 5.4 0.74 9.0 1.1 2.0 1 1 1 2 2 2 0 Voltage-dependent anion channel fn3 PF00041.19 032532.2_26229001_3 - 1.3e-43 147.1 8.6 3.6e-10 39.9 0.0 5.6 5 0 0 5 5 5 5 Fibronectin type III domain Pur_ac_phosph_N PF16656.3 032532.2_26229001_3 - 2.7e-11 43.8 13.4 0.0019 18.6 0.1 5.1 5 0 0 5 5 5 3 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.8 032532.2_26229001_3 - 5e-07 29.8 0.0 0.27 11.4 0.0 4.4 5 0 0 5 5 5 2 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.7 032532.2_26229001_3 - 0.00065 20.0 0.0 0.94 9.9 0.0 4.2 4 0 0 4 4 4 1 Uncharacterised conserved protein (DUF2369) Tissue_fac PF01108.15 032532.2_26229001_3 - 0.00068 19.3 2.5 0.0071 16.0 0.0 3.6 4 0 0 4 4 4 1 Tissue factor Globin PF00042.20 001042626.1_39722001_2 - 1.5e-28 99.4 0.2 2.2e-28 98.9 0.2 1.2 1 0 0 1 1 1 1 Globin Laminin_N PF00055.15 001044548.1_49825001_2 - 6.5e-88 294.1 0.0 6.5e-88 294.1 0.0 3.3 3 1 0 3 3 3 1 Laminin N-terminal (Domain VI) NTR PF01759.19 001044548.1_49825001_2 - 2.5e-31 107.5 0.4 4.5e-31 106.7 0.4 1.4 1 0 0 1 1 1 1 UNC-6/NTR/C345C module Laminin_EGF PF00053.22 001044548.1_49825001_2 - 4.2e-27 93.9 58.4 1.6e-10 40.8 14.8 4.4 4 0 0 4 4 4 3 Laminin EGF domain Selenoprotein_S PF06936.9 173120.2_45723001_2 - 1.3e-93 312.0 0.4 1.9e-93 311.5 0.4 1.2 1 0 0 1 1 1 1 Selenoprotein S (SelS) Pentaxin PF00354.15 001082265.1_37925001_1 - 6.8e-94 312.9 0.0 8.6e-94 312.5 0.0 1.1 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.4 001082265.1_37925001_1 - 4.5e-12 46.2 0.0 6.4e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Ferritin PF00210.22 001101688.1_37922001_3 - 1.5e-29 102.6 2.9 1.8e-29 102.3 2.9 1.1 1 0 0 1 1 1 1 Ferritin-like domain ANAPC4 PF12896.5 001101688.1_37922001_3 - 0.0018 17.7 0.1 0.0025 17.2 0.1 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 SAM_1 PF00536.28 001082164.1_37926001_3 - 9.1e-09 35.5 0.0 1.4e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 001082164.1_37926001_3 - 0.00037 20.3 0.0 0.00064 19.5 0.0 1.3 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_2 PF07647.15 001082164.1_37926001_3 - 0.015 15.3 0.0 0.023 14.7 0.0 1.2 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Ribosomal_60s PF00428.17 001082164.1_37926001_3 - 0.02 15.3 7.5 0.02 15.3 7.5 5.7 3 1 0 3 3 3 0 60s Acidic ribosomal protein PTPRCAP PF15713.3 001082164.1_37926001_3 - 0.23 11.6 7.1 0.41 10.8 7.1 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated PBP1_TM PF14812.4 001082164.1_37926001_3 - 0.92 9.8 6.0 3.3 8.1 6.0 1.9 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FAM176 PF14851.4 001082164.1_37926001_3 - 1.4 8.5 3.9 2.6 7.6 3.9 1.3 1 0 0 1 1 1 0 FAM176 family CENP-B_dimeris PF09026.8 001082164.1_37926001_3 - 7.4 6.9 12.9 13 6.2 12.9 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cpn60_TCP1 PF00118.22 001082039.1_37924001_1 - 4.8e-169 563.0 8.5 5.4e-169 562.8 8.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family IF-2B PF01008.15 001082631.1_37923001_2 - 1.7e-92 309.5 0.0 2.3e-92 309.1 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family DUF3697 PF12478.6 001082631.1_37923001_2 - 0.069 13.1 0.1 0.12 12.3 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin-associated protein 2 Pkinase_Tyr PF07714.15 001111030.1_32929001_1 - 3.3e-31 108.4 0.1 4.5e-31 107.9 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001111030.1_32929001_1 - 1.3e-29 103.2 0.0 1.9e-29 102.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain TGF_beta_GS PF08515.10 001111030.1_32929001_1 - 1e-14 53.6 0.1 2e-14 52.6 0.1 1.5 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Pkinase PF00069.23 001082746.1_37926001_2 - 3.4e-47 160.9 0.0 3.7e-30 105.0 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 001082746.1_37926001_2 - 1.8e-25 89.6 0.1 1.4e-18 67.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.21 001082746.1_37926001_2 - 0.025 14.4 0.0 0.061 13.1 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.12 001082746.1_37926001_2 - 0.037 13.2 0.0 0.068 12.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 001082746.1_37926001_2 - 0.044 13.3 0.1 7.3 6.0 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Nore1-SARAH PF16517.3 019365.3_45727001_3 - 1.3e-16 60.2 6.2 2.5e-16 59.2 6.2 1.5 1 0 0 1 1 1 1 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain RA PF00788.21 019365.3_45727001_3 - 4.1e-15 56.0 0.1 1.9e-14 53.9 0.0 2.1 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain C1_1 PF00130.20 019365.3_45727001_3 - 2.9e-07 30.1 4.6 2.9e-07 30.1 4.6 2.4 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.14 019365.3_45727001_3 - 0.0026 17.9 1.9 0.0026 17.9 1.9 2.1 2 0 0 2 2 2 1 C1 domain LexA_DNA_bind PF01726.14 019365.3_45727001_3 - 0.044 13.4 0.0 0.13 11.9 0.0 1.7 2 0 0 2 2 2 0 LexA DNA binding domain Mst1_SARAH PF11629.6 019365.3_45727001_3 - 0.3 11.1 1.7 0.57 10.2 1.7 1.4 1 0 0 1 1 1 0 C terminal SARAH domain of Mst1 GTP_EFTU PF00009.25 001082031.1_37924001_1 - 4.7e-55 186.0 0.0 6.5e-55 185.5 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.15 001082031.1_37924001_1 - 1.7e-39 134.4 0.0 3.5e-39 133.4 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.23 001082031.1_37924001_1 - 1.4e-14 54.1 1.5 2e-14 53.6 0.4 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.21 001082031.1_37924001_1 - 0.0005 20.0 0.3 0.01 15.7 0.3 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.4 001082031.1_37924001_1 - 0.015 15.2 1.2 0.029 14.2 0.2 2.0 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Dynamin_N PF00350.21 001082031.1_37924001_1 - 0.063 13.2 0.1 13 5.6 0.0 2.4 2 0 0 2 2 2 0 Dynamin family G-alpha PF00503.18 001082031.1_37924001_1 - 0.22 10.5 0.1 0.64 9.0 0.0 1.7 2 0 0 2 2 2 0 G-protein alpha subunit DUF3285 PF11688.6 009228.2_32925001_2 - 0.14 12.0 0.2 0.23 11.3 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3285) PDZ PF00595.22 009228.2_32925001_3 - 1.9e-18 66.4 0.5 3e-18 65.8 0.5 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PH PF00169.27 009228.2_32925001_3 - 2.1e-11 44.1 0.0 4.4e-07 30.2 0.0 2.4 2 0 0 2 2 2 2 PH domain PDZ_2 PF13180.4 009228.2_32925001_3 - 0.002 18.3 0.1 0.0034 17.5 0.1 1.3 1 0 0 1 1 1 1 PDZ domain IF-2B PF01008.15 001082772.1_37924001_1 - 4.2e-90 301.6 0.0 5.4e-90 301.3 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Mpp10 PF04006.10 001082772.1_37924001_1 - 1.5 7.1 8.9 0.063 11.6 2.9 1.6 2 0 0 2 2 2 0 Mpp10 protein Globin PF00042.20 001113425.1_39521001_1 - 3e-31 108.1 0.4 1.3e-30 106.1 0.1 1.8 2 0 0 2 2 2 1 Globin F-actin_cap_A PF01267.15 001168689.1_32325001_2 - 6.9e-106 353.4 2.0 8.6e-106 353.1 2.0 1.1 1 0 0 1 1 1 1 F-actin capping protein alpha subunit SHNi-TPR PF10516.7 001082789.1_37925001_1 - 1.1e-12 47.0 6.1 2.6e-12 45.8 1.8 2.9 3 0 0 3 3 3 1 SHNi-TPR TPR_12 PF13424.4 001082789.1_37925001_1 - 4.6e-09 36.3 5.6 8.2e-09 35.5 4.4 2.0 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.15 001082789.1_37925001_1 - 9.1e-08 31.5 1.3 0.0028 17.5 0.1 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.26 001082789.1_37925001_1 - 8e-07 28.5 1.2 5e-05 22.8 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.4 001082789.1_37925001_1 - 4.8e-06 26.2 4.9 0.042 13.9 0.2 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.4 001082789.1_37925001_1 - 0.0008 19.9 0.3 0.12 13.2 0.1 2.9 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.4 001082789.1_37925001_1 - 0.029 14.9 1.7 13 6.5 0.2 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.4 001082789.1_37925001_1 - 0.064 13.0 1.8 8 6.4 0.1 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.4 001082789.1_37925001_1 - 0.13 11.8 5.0 20 4.9 2.0 3.7 1 1 2 3 3 3 0 TPR repeat DUF4634 PF15465.4 001082789.1_37925001_1 - 5.3 7.2 7.1 0.6 10.3 0.3 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4634) DUF4637 PF15470.4 025492.3_32922001_1 - 4e-85 283.6 7.0 4.9e-85 283.3 7.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4637) CDC45 PF02724.12 025492.3_32922001_1 - 0.49 8.5 3.7 0.58 8.3 3.7 1.0 1 0 0 1 1 1 0 CDC45-like protein Pkinase PF00069.23 001082794.1_37925001_2 - 2.3e-23 82.8 0.0 3.3e-23 82.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001082794.1_37925001_2 - 2.3e-22 79.4 0.0 8e-22 77.6 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Activin_recp PF01064.21 001082794.1_37925001_2 - 0.0019 19.1 6.2 0.0019 19.1 6.2 2.0 2 0 0 2 2 2 1 Activin types I and II receptor domain APH PF01636.21 001082794.1_37925001_2 - 0.11 12.2 4.4 0.14 11.9 0.0 2.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family Metal_resist PF13801.4 001082794.1_37925001_2 - 4.9 7.2 10.1 8.5 6.4 0.0 3.9 4 0 0 4 4 4 0 Heavy-metal resistance Globin PF00042.20 001097648.1_39521001_1 - 5.1e-32 110.6 1.1 9.1e-32 109.8 0.1 1.7 2 0 0 2 2 2 1 Globin Asp PF00026.21 001082696.1_37923001_2 - 1.4e-112 376.0 0.0 1.7e-112 375.8 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001082696.1_37923001_2 - 5.8e-13 49.3 0.4 3.1e-10 40.5 0.4 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001082696.1_37923001_2 - 1.5e-10 40.6 0.3 2.4e-10 39.9 0.3 1.3 1 0 0 1 1 1 1 A1 Propeptide Pkinase PF00069.23 001081999.1_37927001_1 - 6.6e-77 258.3 0.0 1.5e-76 257.2 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001081999.1_37927001_1 - 6.1e-37 127.2 0.0 2.6e-36 125.1 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.20 001081999.1_37927001_1 - 0.00038 20.0 0.1 0.00078 19.0 0.1 1.4 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.4 001081999.1_37927001_1 - 0.0093 15.2 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 001081999.1_37927001_1 - 0.015 14.6 0.1 0.027 13.7 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CFTR_R PF14396.4 001081999.1_37927001_1 - 0.029 13.8 0.8 0.045 13.2 0.8 1.2 1 0 0 1 1 1 0 Cystic fibrosis TM conductance regulator (CFTR), regulator domain APH PF01636.21 001081999.1_37927001_1 - 0.16 11.7 0.0 0.59 9.9 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family zf-CGNR PF11706.6 001081999.1_37927001_1 - 0.49 10.2 5.2 4.5 7.1 1.8 2.6 2 0 0 2 2 2 0 CGNR zinc finger Glyco_hydro_31 PF01055.24 001082266.1_37929001_3 - 3e-297 985.5 20.4 5.5e-153 510.1 4.4 2.2 2 0 0 2 2 2 2 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.3 001082266.1_37929001_3 - 3.2e-69 230.3 1.9 1.7e-35 121.6 0.3 2.6 2 0 0 2 2 2 2 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Trefoil PF00088.16 001082266.1_37929001_3 - 1.5e-18 66.2 15.7 4.7e-10 39.0 6.7 2.6 2 0 0 2 2 2 2 Trefoil (P-type) domain Gal_mutarotas_2 PF13802.4 001082266.1_37929001_3 - 2.2e-11 43.8 7.2 3.9e-05 23.8 0.8 2.9 2 0 0 2 2 2 2 Galactose mutarotase-like EPTP PF03736.15 001071816.1_39724001_1 - 4.9e-73 240.8 4.8 2.2e-11 43.4 0.0 7.3 7 0 0 7 7 7 7 EPTP domain LRR_8 PF13855.4 001071816.1_39724001_1 - 2.8e-21 74.9 17.6 5.1e-13 48.4 6.3 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_5 PF13306.4 001071816.1_39724001_1 - 4.9e-07 29.6 0.1 7.9e-07 29.0 0.1 1.2 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_4 PF12799.5 001071816.1_39724001_1 - 0.00018 21.7 14.4 0.012 15.9 2.1 2.8 1 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.4 001071816.1_39724001_1 - 0.0003 20.2 0.4 0.00049 19.5 0.4 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRRCT PF01463.22 001071816.1_39724001_1 - 0.0013 19.0 0.5 0.011 16.0 0.6 2.7 2 0 0 2 2 2 1 Leucine rich repeat C-terminal domain PFU PF09070.9 001071816.1_39724001_1 - 0.12 12.5 0.1 0.44 10.7 0.0 1.9 2 0 0 2 2 2 0 PFU (PLAA family ubiquitin binding) LRR_1 PF00560.31 001071816.1_39724001_1 - 5.8 7.7 11.9 4.9 7.9 0.4 4.5 4 0 0 4 4 4 0 Leucine Rich Repeat Pkinase PF00069.23 001082758.1_37925001_3 - 5.7e-64 215.9 0.0 7e-64 215.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001082758.1_37925001_3 - 1e-32 113.3 0.0 1.6e-32 112.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PB1 PF00564.22 001082758.1_37925001_3 - 4.1e-15 55.3 0.0 8.7e-15 54.3 0.0 1.6 1 0 0 1 1 1 1 PB1 domain C1_1 PF00130.20 001082758.1_37925001_3 - 5.5e-15 54.9 6.2 1e-14 54.0 6.2 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.4 001082758.1_37925001_3 - 6e-05 22.4 0.0 0.00013 21.3 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Pkinase_C PF00433.22 001082758.1_37925001_3 - 0.0029 18.1 1.6 0.0079 16.7 1.6 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain APH PF01636.21 001082758.1_37925001_3 - 0.0074 16.1 0.1 0.24 11.2 0.1 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family C1_2 PF03107.14 001082758.1_37925001_3 - 0.025 14.8 5.9 0.12 12.6 2.4 2.4 2 0 0 2 2 2 0 C1 domain Kdo PF06293.12 001082758.1_37925001_3 - 0.057 12.6 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 001082758.1_37925001_3 - 0.064 12.7 0.2 1.8 8.0 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DZR PF12773.5 001082758.1_37925001_3 - 0.14 12.1 1.5 0.36 10.8 1.5 1.7 1 0 0 1 1 1 0 Double zinc ribbon DUF4504 PF14953.4 001103357.1_45724001_2 - 1.1e-72 244.5 0.0 1.3e-72 244.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4504) Pro_isomerase PF00160.19 001112655.1_40421001_1 - 1.5e-43 148.7 0.2 1.7e-43 148.5 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ferritin PF00210.22 001048151.1_22422001_1 - 3.7e-39 133.8 4.5 4.6e-39 133.5 4.5 1.1 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.15 001048151.1_22422001_1 - 0.0048 17.2 0.4 0.0063 16.8 0.4 1.3 1 0 0 1 1 1 1 Rubrerythrin Mad3_BUB1_I_2 PF17014.3 001048151.1_22422001_1 - 0.11 12.5 1.7 1.3 9.0 0.4 2.2 2 0 0 2 2 2 0 Putative Mad3/BUB1 like region 1 protein PRY PF13765.4 001114168.1_39723001_1 - 2.5e-17 62.1 0.0 4.6e-17 61.2 0.0 1.5 1 0 0 1 1 1 1 SPRY-associated domain zf-C3HC4_4 PF15227.4 001114168.1_39723001_1 - 1.8e-07 31.1 8.3 3.6e-07 30.1 8.3 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001114168.1_39723001_1 - 1.2e-06 28.2 6.0 2.1e-06 27.3 6.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.4 001114168.1_39723001_1 - 1.2e-05 25.1 8.7 2.5e-05 24.1 8.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.4 001114168.1_39723001_1 - 2.5e-05 23.9 9.2 8.9e-05 22.1 9.2 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001114168.1_39723001_1 - 4.9e-05 23.4 7.6 0.00011 22.3 7.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.4 001114168.1_39723001_1 - 7.2e-05 22.5 5.2 0.00019 21.2 5.2 1.7 1 1 0 1 1 1 1 zinc-RING finger domain SPRY PF00622.26 001114168.1_39723001_1 - 0.00012 22.1 0.0 0.00017 21.5 0.0 1.2 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_3 PF13920.4 001114168.1_39723001_1 - 0.0016 18.2 8.0 0.003 17.3 8.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.4 001114168.1_39723001_1 - 0.0072 16.0 5.2 0.02 14.6 5.2 1.8 1 1 0 1 1 1 1 zf-RING of BARD1-type protein zf-4CXXC_R1 PF10497.7 001114168.1_39723001_1 - 0.1 12.7 2.9 0.23 11.6 2.9 1.5 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-Nse PF11789.6 001114168.1_39723001_1 - 0.16 11.7 1.2 0.32 10.7 1.2 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.4 001114168.1_39723001_1 - 0.33 10.7 11.6 2.3 8.0 11.9 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 UCH PF00443.27 001082257.1_37924001_1 - 9.5e-51 172.6 1.1 1.2e-50 172.3 1.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 001082257.1_37924001_1 - 2.4e-14 53.5 7.3 4.7e-14 52.6 7.3 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.21 001082257.1_37924001_1 - 0.00044 19.8 0.0 0.00089 18.8 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Peptidase_C98 PF15499.4 001082257.1_37924001_1 - 0.021 14.2 2.3 0.036 13.4 0.1 2.1 2 0 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase F-actin_cap_A PF01267.15 001168717.1_40425001_2 - 8.3e-106 353.1 1.2 1.1e-105 352.8 1.2 1.1 1 0 0 1 1 1 1 F-actin capping protein alpha subunit LRR_8 PF13855.4 001082195.2_37923001_2 - 2.4e-09 36.7 1.4 0.00036 20.1 0.4 4.1 3 1 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.5 001082195.2_37923001_2 - 3.9e-08 33.3 3.5 0.021 15.1 0.2 5.0 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.4 001082195.2_37923001_2 - 0.0031 17.3 8.4 6.5 6.9 0.0 5.2 5 0 0 5 5 5 2 Leucine Rich repeat LRR_1 PF00560.31 001082195.2_37923001_2 - 0.017 15.3 7.2 13 6.6 0.5 5.1 4 2 0 4 4 4 0 Leucine Rich Repeat Orexin PF02072.13 214156.2_49822001_2 - 2.4e-72 240.8 9.1 2.8e-72 240.6 9.1 1.1 1 0 0 1 1 1 1 Prepro-orexin SNF PF00209.16 001082397.1_37925001_3 - 5.8e-240 797.3 38.1 6.8e-240 797.0 38.1 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family YqzM PF14141.4 001082397.1_37925001_3 - 3.6 7.6 5.8 82 3.2 4.0 2.8 2 0 0 2 2 2 0 YqzM-like protein DUF4381 PF14316.4 001082397.1_37925001_3 - 5.1 7.2 9.7 6.3 6.9 1.8 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) Ion_trans PF00520.29 010595.3_32929001_2 - 1.7e-49 168.1 13.4 1.7e-49 168.1 13.4 1.8 2 0 0 2 2 2 1 Ion transport protein BTB_2 PF02214.20 010595.3_32929001_2 - 9.3e-28 96.3 0.0 1.7e-27 95.4 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.14 010595.3_32929001_2 - 5.1e-13 48.7 5.3 5.1e-13 48.7 5.3 2.4 3 0 0 3 3 3 1 Ion channel PKD_channel PF08016.10 010595.3_32929001_2 - 0.025 13.2 1.3 0.042 12.4 1.3 1.2 1 0 0 1 1 1 0 Polycystin cation channel Ribosomal_60s PF00428.17 001129964.1_49822001_3 - 5.8e-23 81.1 0.2 5.8e-23 81.1 0.2 2.1 2 0 0 2 2 2 1 60s Acidic ribosomal protein Glyco_hydro_18 PF00704.26 001112617.1_40425001_1 - 8.8e-76 255.5 0.0 1.1e-75 255.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Tetraspannin PF00335.18 001082199.1_37922001_2 - 2.4e-48 164.6 18.8 2.8e-48 164.4 18.8 1.0 1 0 0 1 1 1 1 Tetraspanin family ABC2_membrane_3 PF12698.5 001082199.1_37922001_2 - 5.6 5.8 8.9 8.2 5.3 8.9 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein SUR7 PF06687.10 001082199.1_37922001_2 - 7.6 6.0 21.7 28 4.1 0.3 3.0 2 1 0 2 2 2 0 SUR7/PalI family Ofd1_CTDD PF10637.7 177767.4_32929001_2 - 4.3e-41 140.8 0.1 4.3e-38 131.0 0.0 2.5 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.4 177767.4_32929001_2 - 2.6e-33 114.4 0.1 2.4e-29 101.7 0.0 2.4 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.4 177767.4_32929001_2 - 3.7e-15 56.5 0.0 1.7e-13 51.1 0.0 2.3 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily ST7 PF04184.10 001135847.1_39724001_1 - 0 1073.7 1.9 0 1073.5 1.9 1.0 1 0 0 1 1 1 1 ST7 protein TPR_6 PF13174.4 001135847.1_39724001_1 - 0.00061 20.1 0.0 0.0033 17.8 0.0 2.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.15 001135847.1_39724001_1 - 0.0051 16.7 0.2 4.8 7.4 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat Clathrin PF00637.18 001135847.1_39724001_1 - 0.06 13.1 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Region in Clathrin and VPS TPR_19 PF14559.4 001135847.1_39724001_1 - 0.14 12.5 4.9 0.41 11.0 0.5 3.3 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.26 001135847.1_39724001_1 - 1.4 8.7 3.4 1.1e+02 2.8 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.4 001135847.1_39724001_1 - 2.3 9.1 8.2 14 6.6 0.0 4.6 3 2 2 5 5 5 0 Tetratricopeptide repeat Complex1_30kDa PF00329.17 001079913.1_39722001_1 - 3.6e-45 153.4 0.0 4.8e-45 153.0 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit SelK_SelG PF10961.6 001044553.1_49822001_3 - 1e-26 93.2 0.3 1e-26 93.2 0.3 1.9 2 0 0 2 2 2 1 Selenoprotein SelK_SelG Crystall PF00030.17 001099970.1_37922001_1 - 4.6e-57 190.0 2.7 5.6e-28 96.8 0.1 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.11 001099970.1_37922001_1 - 0.00013 21.7 1.4 0.47 10.3 0.0 3.1 1 1 2 3 3 3 3 Peptidase inhibitor family I36 Laminin_G_1 PF00054.21 001082370.1_37923001_2 - 7.3e-29 100.5 0.0 6.1e-27 94.3 0.0 2.3 2 0 0 2 2 2 1 Laminin G domain Laminin_G_2 PF02210.22 001082370.1_37923001_2 - 4e-16 59.6 0.0 1.4e-13 51.4 0.0 2.5 3 0 0 3 3 3 2 Laminin G domain Laminin_G_3 PF13385.4 001082370.1_37923001_2 - 0.0036 17.3 0.0 0.008 16.2 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF1080 PF06439.9 001082370.1_37923001_2 - 0.041 13.9 0.0 0.066 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) RasGEF PF00617.17 001039087.1_32929001_2 - 9.2e-52 175.6 0.4 3.8e-51 173.6 0.1 2.0 1 1 1 2 2 2 1 RasGEF domain RasGEF_N PF00618.18 001039087.1_32929001_2 - 2.3e-09 37.3 0.2 2.3e-09 37.3 0.2 2.1 3 0 0 3 3 3 1 RasGEF N-terminal motif LRR_6 PF13516.4 001008333.2_45723001_2 - 4.5e-12 44.9 15.4 0.027 14.4 0.1 7.1 8 0 0 8 8 8 5 Leucine Rich repeat LRR_4 PF12799.5 001008333.2_45723001_2 - 0.0011 19.1 8.1 0.1 12.9 0.2 4.5 2 1 4 6 6 6 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001008333.2_45723001_2 - 0.015 15.6 6.9 75 4.3 0.2 6.2 5 1 0 5 5 5 0 Leucine Rich Repeat Rieske_2 PF13806.4 001008333.2_45723001_2 - 0.11 12.3 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Rieske-like [2Fe-2S] domain Mito_carr PF00153.25 001082777.1_37927001_2 - 1.8e-72 239.2 4.3 2.8e-25 87.9 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.30 001082777.1_37927001_2 - 1.5e-19 67.9 5.9 3.5e-05 22.9 1.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.4 001082777.1_37927001_2 - 1e-18 67.4 2.3 4.3e-09 36.6 0.3 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.4 001082777.1_37927001_2 - 4.3e-18 63.5 7.0 0.0001 21.8 0.0 4.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.4 001082777.1_37927001_2 - 3e-15 54.8 6.8 6.4e-05 22.2 0.1 4.0 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.4 001082777.1_37927001_2 - 9e-12 44.5 3.1 6.4e-06 25.7 0.6 3.9 2 2 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.7 001082777.1_37927001_2 - 4.1e-07 30.2 0.1 0.031 14.5 0.2 2.3 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.5 001082777.1_37927001_2 - 0.0003 20.6 0.8 0.0026 17.5 0.2 2.2 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.4 001082777.1_37927001_2 - 0.0009 18.9 0.2 0.33 10.7 0.1 3.0 2 1 1 3 3 3 1 EF hand EF-hand_9 PF14658.4 001082777.1_37927001_2 - 0.056 13.6 0.0 24 5.2 0.0 2.8 2 1 0 2 2 2 0 EF-hand domain Porin_3 PF01459.20 001083338.1_45722001_1 - 5.5e-65 219.4 0.0 6.4e-65 219.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic porin Glyco_hydro_35 PF01301.17 001024358.1_45725001_3 - 2.1e-109 365.9 0.5 2.7e-109 365.5 0.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.13 001024358.1_45725001_3 - 1.6e-10 40.7 0.1 1.7e-08 34.1 0.0 3.1 2 1 1 3 3 3 1 Beta-galactosidase BetaGal_dom4_5 PF13364.4 001024358.1_45725001_3 - 0.41 11.1 2.5 5 7.6 0.1 2.9 3 0 0 3 3 3 0 Beta-galactosidase jelly roll domain PKI PF02827.14 001039052.1_32929001_1 - 3.1e-25 88.0 0.5 3.1e-25 88.0 0.5 1.9 2 0 0 2 2 2 1 cAMP-dependent protein kinase inhibitor GnRH PF00446.15 012767.2_45721001_3 - 0.00011 22.1 3.2 0.00011 22.1 3.2 1.8 2 0 0 2 2 2 1 Gonadotropin-releasing hormone Rad60-SLD PF11976.6 001112677.1_49821001_1 - 6.3e-23 80.3 0.0 7.6e-23 80.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.21 001112677.1_49821001_1 - 3.6e-09 36.1 0.1 4.5e-09 35.8 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin family TNF PF00229.16 001076784.1_39722001_1 - 9.1e-35 119.2 0.0 1.1e-34 118.9 0.0 1.1 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family Lectin_C PF00059.19 001082633.1_37924001_3 - 2.2e-16 60.4 0.1 5.1e-16 59.2 0.1 1.6 1 0 0 1 1 1 1 Lectin C-type domain Ly49 PF08391.8 001082633.1_37924001_3 - 2.4e-07 31.0 0.5 5.2e-07 29.9 0.5 1.5 1 0 0 1 1 1 1 Ly49-like protein, N-terminal region UL45 PF05473.10 001082633.1_37924001_3 - 7.6e-05 22.3 0.0 0.00082 18.9 0.0 2.3 2 0 0 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like HemX PF04375.12 001082633.1_37924001_3 - 0.00015 21.0 4.8 0.00023 20.4 4.8 1.2 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase IncA PF04156.12 001082633.1_37924001_3 - 0.0012 18.5 4.7 0.0023 17.6 4.7 1.4 1 0 0 1 1 1 1 IncA protein MMR_HSR1 PF01926.21 001071796.1_39724001_1 - 9e-14 51.4 0.0 2.6e-13 49.9 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.16 001071796.1_39724001_1 - 6.5e-05 22.4 0.1 0.00043 19.7 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.14 001071796.1_39724001_1 - 0.003 17.3 0.0 0.13 12.0 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 Dynamin_N PF00350.21 001071796.1_39724001_1 - 0.063 13.2 0.4 0.063 13.2 0.4 3.0 4 1 1 5 5 5 0 Dynamin family HbrB PF08539.9 001071796.1_39724001_1 - 0.11 12.3 0.2 0.29 11.0 0.0 1.7 2 0 0 2 2 2 0 HbrB-like NUDIX PF00293.26 001038013.1_39522001_2 - 1.4e-05 25.0 0.1 2.1e-05 24.5 0.1 1.2 1 0 0 1 1 1 1 NUDIX domain Pkinase PF00069.23 001082056.1_37924001_2 - 5.2e-70 235.7 0.0 7.4e-70 235.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001082056.1_37924001_2 - 2.1e-35 122.1 0.0 3.3e-35 121.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001082056.1_37924001_2 - 6e-07 28.9 0.1 1.7e-06 27.5 0.1 1.7 1 1 0 1 1 1 1 Kinase-like Pkinase_C PF00433.22 001082056.1_37924001_2 - 3.2e-06 27.6 0.0 7.3e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kdo PF06293.12 001082056.1_37924001_2 - 0.0066 15.7 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.4 001082056.1_37924001_2 - 0.0083 15.6 0.1 1.2 8.5 0.1 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 ubiquitin PF00240.21 001044222.1_32322001_1 - 9.8e-16 57.1 0.1 1.4e-15 56.6 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 001044222.1_32322001_1 - 2.2e-06 27.3 0.0 3.2e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 001044222.1_32322001_1 - 0.026 15.0 0.4 0.042 14.3 0.4 1.6 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain F-actin_cap_A PF01267.15 001171021.1_37925001_2 - 7.9e-106 353.2 1.4 9.9e-106 352.9 1.4 1.1 1 0 0 1 1 1 1 F-actin capping protein alpha subunit PAP2_C PF14360.4 001097438.2_49825001_3 - 1.6e-27 95.7 14.6 1.6e-27 95.7 14.6 2.3 3 0 0 3 3 3 1 PAP2 superfamily C-terminal PAP2 PF01569.19 001097438.2_49825001_3 - 2.8e-07 30.2 7.2 7.1e-07 29.0 7.2 1.7 1 0 0 1 1 1 1 PAP2 superfamily SAM_1 PF00536.28 001097438.2_49825001_3 - 0.00035 20.8 0.0 0.00088 19.5 0.0 1.6 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PAP2_3 PF14378.4 001097438.2_49825001_3 - 0.0019 17.8 16.1 0.012 15.2 16.2 2.0 1 1 0 1 1 1 1 PAP2 superfamily SAM_PNT PF02198.14 001097438.2_49825001_3 - 0.018 14.9 0.1 0.083 12.7 0.1 2.2 1 1 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain SAM_2 PF07647.15 001097438.2_49825001_3 - 0.031 14.2 0.0 0.065 13.2 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Globin PF00042.20 001171504.1_37921001_1 - 7.1e-31 106.9 0.0 2e-30 105.5 0.0 1.6 2 0 0 2 2 2 1 Globin LRR_6 PF13516.4 001133584.1_43528001_3 - 9.3e-18 62.6 29.8 0.0003 20.5 0.0 9.7 10 0 0 10 10 10 5 Leucine Rich repeat LRR_4 PF12799.5 001133584.1_43528001_3 - 1.3e-12 47.6 18.5 0.055 13.8 0.3 6.7 5 1 0 6 6 6 5 Leucine Rich repeats (2 copies) F-box-like PF12937.5 001133584.1_43528001_3 - 4.9e-11 42.2 0.5 1.5e-10 40.7 0.5 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.31 001133584.1_43528001_3 - 3.9e-07 29.7 0.6 1.2e-06 28.1 0.6 1.9 1 0 0 1 1 1 1 F-box domain LRR_8 PF13855.4 001133584.1_43528001_3 - 0.0034 17.0 9.8 1 9.0 1.2 4.9 5 1 1 6 6 6 2 Leucine rich repeat LRR_1 PF00560.31 001133584.1_43528001_3 - 0.0055 16.9 30.3 3.1 8.5 0.0 10.0 9 2 0 9 9 9 2 Leucine Rich Repeat F-box_4 PF15966.3 001133584.1_43528001_3 - 0.046 13.5 0.0 0.18 11.5 0.0 2.0 1 0 0 1 1 1 0 F-box LRR19-TM PF15176.4 001101709.2_37923001_1 - 0.64 9.9 2.1 1.4 8.8 0.9 2.1 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain Tmem26 PF09772.7 001101709.2_37923001_1 - 1 8.5 9.6 0.036 13.3 2.4 2.1 2 0 0 2 2 2 0 Transmembrane protein 26 Smac_DIABLO PF09057.8 001132035.2_43523001_3 - 2e-102 341.2 8.2 2.5e-102 340.9 8.2 1.1 1 0 0 1 1 1 1 Second Mitochondria-derived Activator of Caspases Utp14 PF04615.11 001001981.3_32928001_1 - 2e-159 532.4 40.4 4.8e-159 531.2 40.4 1.5 1 1 0 1 1 1 1 Utp14 protein IL1 PF00340.17 001172968.1_09923001_1 - 1.1e-42 144.4 0.2 1.7e-42 143.7 0.2 1.3 1 0 0 1 1 1 1 Interleukin-1 / 18 IL1_propep PF02394.14 001172968.1_09923001_1 - 2e-36 125.1 0.0 3.6e-36 124.2 0.0 1.4 1 0 0 1 1 1 1 Interleukin-1 propeptide EIF_2_alpha PF07541.10 001133534.1_43529001_2 - 4.8e-36 123.3 0.0 7.7e-36 122.6 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.21 001133534.1_43529001_2 - 1.7e-15 57.0 2.4 1.9e-15 56.8 1.1 1.7 2 0 0 2 2 2 1 S1 RNA binding domain Draxin PF15550.4 027426.3_32929001_1 - 2.5e-133 444.7 5.1 3.7e-133 444.2 5.1 1.2 1 0 0 1 1 1 1 Draxin TDRP PF15683.3 001100791.1_45725001_3 - 1.5e-67 226.1 9.2 1.5e-67 226.1 9.2 2.2 2 0 0 2 2 2 1 Testis development-related protein FtsJ PF01728.17 001132150.1_43528001_3 - 2.6e-29 102.4 0.1 6.4e-27 94.7 0.0 2.3 2 0 0 2 2 2 2 FtsJ-like methyltransferase DUF2615 PF11027.6 001131269.2_43524001_1 - 1.1e-36 125.1 0.0 2.4e-36 123.9 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2615) Asp PF00026.21 001171085.1_37923001_2 - 2.2e-122 408.3 4.0 2.5e-122 408.1 4.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001171085.1_37923001_2 - 7e-16 58.9 3.2 2.4e-09 37.6 0.1 2.5 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001171085.1_37923001_2 - 9.9e-11 41.2 1.0 1.7e-10 40.4 1.0 1.4 1 0 0 1 1 1 1 A1 Propeptide Asp_protease_2 PF13650.4 001171085.1_37923001_2 - 0.00013 22.5 0.1 0.041 14.4 0.0 2.5 2 0 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.4 001171085.1_37923001_2 - 0.091 13.2 0.0 2.6 8.5 0.0 2.7 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease F-actin_cap_A PF01267.15 001168692.1_22425001_2 - 6e-106 353.6 1.7 7.2e-106 353.3 1.7 1.1 1 0 0 1 1 1 1 F-actin capping protein alpha subunit CAP_N PF01213.17 001168692.1_22425001_2 - 0.18 11.1 0.7 4.5 6.5 0.0 2.2 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal LRR_6 PF13516.4 001132463.1_43526001_2 - 0.0011 18.7 13.5 0.26 11.3 0.0 4.9 6 0 0 6 6 6 3 Leucine Rich repeat Ufm1 PF03671.12 001131838.1_43527001_1 - 5.1e-41 138.5 0.1 8.1e-41 137.9 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin fold modifier 1 protein ST7 PF04184.10 001168697.1_22424001_1 - 0 1073.7 1.9 0 1073.5 1.9 1.0 1 0 0 1 1 1 1 ST7 protein TPR_6 PF13174.4 001168697.1_22424001_1 - 0.00063 20.1 0.0 0.0033 17.8 0.0 2.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.15 001168697.1_22424001_1 - 0.0051 16.7 0.2 4.8 7.4 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat Clathrin PF00637.18 001168697.1_22424001_1 - 0.06 13.1 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Region in Clathrin and VPS TPR_19 PF14559.4 001168697.1_22424001_1 - 0.15 12.5 4.9 0.41 11.1 0.5 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.26 001168697.1_22424001_1 - 1.4 8.7 3.4 1.1e+02 2.8 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.4 001168697.1_22424001_1 - 2.4 9.1 8.2 15 6.6 0.0 4.6 3 2 2 5 5 5 0 Tetratricopeptide repeat p53-inducible11 PF14936.4 001131369.1_43527001_1 - 2.7e-85 284.9 1.3 3.5e-85 284.5 1.3 1.1 1 0 0 1 1 1 1 Tumour protein p53-inducible protein 11 DUF4171 PF13775.4 001131369.1_43527001_1 - 0.06 13.7 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4171) Lectin_N PF03954.12 001131984.1_43523001_1 - 4.5e-60 201.0 6.4 7.2e-60 200.3 6.4 1.3 1 0 0 1 1 1 1 Hepatic lectin, N-terminal domain Lectin_C PF00059.19 001131984.1_43523001_1 - 6.2e-24 84.7 1.2 1.1e-23 83.9 1.2 1.4 1 0 0 1 1 1 1 Lectin C-type domain OATP PF03137.18 001131984.1_43523001_1 - 2.2 6.3 4.6 4.1 5.4 4.6 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family OATP PF03137.18 001131984.1_43523001_2 - 0.8 7.8 6.5 1.1 7.3 6.5 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Connexin PF00029.17 001131984.1_43523001_2 - 0.86 9.2 4.0 1.2 8.7 4.0 1.1 1 0 0 1 1 1 0 Connexin MAS20 PF02064.13 001131984.1_43523001_2 - 4.9 7.1 13.0 7 6.6 13.0 1.2 1 0 0 1 1 1 0 MAS20 protein import receptor OAD_gamma PF04277.11 001131984.1_43523001_2 - 9.3 6.8 12.1 19 5.8 12.1 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Pentaxin PF00354.15 001172728.1_09924001_1 - 7.8e-34 116.9 0.0 1.1e-33 116.5 0.0 1.2 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.4 001172728.1_09924001_1 - 1.4e-14 54.4 0.0 2.2e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily ESX-1_EspG PF14011.4 001172728.1_09924001_1 - 0.0066 16.0 1.3 0.0099 15.4 0.9 1.4 1 1 0 1 1 1 1 EspG family GOLGA2L5 PF15070.4 001172728.1_09924001_1 - 0.0086 14.7 11.8 0.012 14.2 11.8 1.1 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 GrpE PF01025.17 001172728.1_09924001_1 - 0.12 11.8 4.6 0.28 10.7 4.6 1.7 1 1 0 1 1 1 0 GrpE CorA PF01544.16 001172728.1_09924001_1 - 0.67 9.1 7.5 0.39 9.8 4.9 1.7 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Exonuc_VII_L PF02601.13 001172728.1_09924001_1 - 0.69 9.3 4.2 1.1 8.6 4.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2570 PF10828.6 001172728.1_09924001_1 - 1 9.1 3.6 0.67 9.7 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) SlyX PF04102.10 001172728.1_09924001_1 - 1.1 9.8 11.8 8.7 6.9 0.1 3.7 3 1 0 3 3 3 0 SlyX CLZ PF16526.3 001172728.1_09924001_1 - 3 8.1 11.5 6.3 7.1 0.2 2.5 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ABC_tran_CTD PF16326.3 001172728.1_09924001_1 - 6.5 7.0 10.1 9.7 6.4 4.6 2.8 1 1 2 3 3 3 0 ABC transporter C-terminal domain Globin PF00042.20 001071779.2_39721001_1 - 1.2e-31 109.4 0.0 3.8e-31 107.8 0.0 1.7 2 0 0 2 2 2 1 Globin TM231 PF10149.7 001131961.2_43526001_2 - 8.6e-124 412.6 0.1 1e-123 412.3 0.1 1.1 1 0 0 1 1 1 1 Transmembrane protein 231 PTPLA PF04387.12 001132017.1_43529001_1 - 4.1e-58 195.6 11.7 6.7e-58 194.9 11.7 1.4 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA RNA_pol_Rpb4 PF03874.14 001172933.1_09924001_1 - 2.5e-29 102.0 5.2 3.8e-29 101.4 5.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb4 Muted PF14942.4 001172933.1_09924001_1 - 0.17 12.0 4.8 0.051 13.7 1.5 1.8 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein Guanylate_cyc PF00211.18 001172959.2_09928001_2 - 4.7e-63 212.0 0.0 7.6e-63 211.3 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Pkinase_Tyr PF07714.15 001172959.2_09928001_2 - 5.2e-30 104.4 0.0 1.5e-29 103.0 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001172959.2_09928001_2 - 4.2e-25 88.5 0.3 2.4e-24 86.0 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain ANF_receptor PF01094.26 001172959.2_09928001_2 - 1.4e-08 34.1 0.0 2.9e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Receptor family ligand binding region Glycophorin_A PF01102.16 001172959.2_09928001_2 - 0.037 14.1 0.0 0.077 13.1 0.0 1.5 1 0 0 1 1 1 0 Glycophorin A Syndecan PF01034.18 001172959.2_09928001_2 - 0.16 11.7 1.0 0.38 10.6 1.0 1.6 1 0 0 1 1 1 0 Syndecan domain DUF1049 PF06305.9 001172959.2_09928001_2 - 0.18 11.5 0.3 0.38 10.5 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Ribosomal_L5 PF00281.17 001131913.2_43522001_1 - 4.7e-23 81.1 0.0 3.1e-21 75.3 0.0 2.6 2 0 0 2 2 2 1 Ribosomal protein L5 Ribosomal_L5_C PF00673.19 001131913.2_43522001_1 - 1.1e-21 76.7 0.0 2.1e-21 75.8 0.0 1.5 1 0 0 1 1 1 1 ribosomal L5P family C-terminus DUF4604 PF15377.4 001131913.2_43522001_1 - 0.4 11.0 24.1 0.75 10.1 24.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Med19 PF10278.7 001131913.2_43522001_1 - 3.5 7.4 28.2 4.7 7.0 28.2 1.3 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 SR-25 PF10500.7 001131913.2_43522001_2 - 0.0031 17.0 27.9 0.0051 16.3 27.9 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF4604 PF15377.4 001131913.2_43522001_2 - 0.14 12.4 20.6 0.21 11.9 20.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) RNA_polI_A34 PF08208.9 001131913.2_43522001_2 - 0.66 9.9 25.3 0.79 9.7 25.3 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 IP_trans PF02121.16 001171151.1_37922001_1 - 3.5e-121 403.3 3.4 4.1e-121 403.1 3.4 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein Ferritin PF00210.22 001132636.1_43522001_2 - 2.8e-38 130.9 4.5 3.6e-38 130.5 4.5 1.2 1 0 0 1 1 1 1 Ferritin-like domain Coat_F PF07875.10 001132636.1_43522001_2 - 0.7 10.0 4.6 15 5.7 0.4 2.6 2 0 0 2 2 2 0 Coat F domain Shadoo PF14999.4 001162561.1_39526001_2 - 7.7e-56 187.7 30.0 2e-55 186.4 30.0 1.8 1 0 0 1 1 1 1 Shadow of prion protein, neuroprotective Pro_isomerase PF00160.19 001132784.1_43524001_1 - 1.4e-44 152.0 0.0 2.8e-44 151.0 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD F-actin_cap_A PF01267.15 001135817.1_39725001_2 - 8.2e-106 353.2 1.2 1.1e-105 352.8 1.2 1.1 1 0 0 1 1 1 1 F-actin capping protein alpha subunit Pkinase PF00069.23 001171277.1_37923001_1 - 3.9e-68 229.6 0.0 5e-68 229.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001171277.1_37923001_1 - 2.3e-32 112.2 0.0 3.3e-32 111.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001171277.1_37923001_1 - 0.0016 17.7 0.1 0.0041 16.4 0.0 1.7 2 0 0 2 2 2 1 Kinase-like APH PF01636.21 001171277.1_37923001_1 - 0.021 14.6 0.0 0.086 12.6 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.4 001171277.1_37923001_1 - 0.067 12.7 0.0 6 6.3 0.0 2.5 2 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 NUDIX PF00293.26 001132274.1_43528001_1 - 1.2e-17 64.1 0.5 1.8e-17 63.5 0.5 1.2 1 0 0 1 1 1 1 NUDIX domain AP3D1 PF06375.9 001132274.1_43528001_3 - 0.25 11.5 8.8 0.34 11.0 8.8 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 HECT_2 PF09814.7 001131170.1_43524001_1 - 7.3e-69 232.3 7.0 8.9e-69 232.0 7.0 1.1 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding SNF PF00209.16 001133063.1_43529001_3 - 2.8e-178 593.7 30.2 2.8e-178 593.7 30.2 2.2 2 0 0 2 2 2 1 Sodium:neurotransmitter symporter family Keratin_B2 PF01500.15 033184.3_26222001_2 - 9.5e-15 54.8 92.1 1.4e-09 38.1 43.4 2.3 2 0 0 2 2 2 2 Keratin, high sulfur B2 protein Keratin_B2_2 PF13885.4 033184.3_26222001_2 - 8.7e-06 25.5 130.9 0.0066 16.2 45.1 4.4 1 1 2 3 3 3 3 Keratin, high sulfur B2 protein ISK_Channel PF02060.13 001198937.1_37921001_1 - 2.9e-16 59.1 0.3 3.3e-16 59.0 0.3 1.2 1 0 0 1 1 1 1 Slow voltage-gated potassium channel TMEM154 PF15102.4 001198937.1_37921001_1 - 0.013 15.2 0.6 3.2 7.5 0.2 2.1 1 1 1 2 2 2 0 TMEM154 protein family Viral_Beta_CD PF04530.10 001198937.1_37921001_1 - 0.13 12.5 0.2 0.16 12.1 0.2 1.2 1 0 0 1 1 1 0 Viral Beta C/D like family Tetraspannin PF00335.18 001198937.1_37921001_1 - 0.14 11.8 0.2 0.2 11.4 0.2 1.2 1 1 0 1 1 1 0 Tetraspanin family PRR20 PF15708.3 001198937.1_37921001_3 - 0.22 11.3 2.5 0.24 11.2 2.0 1.3 1 1 0 1 1 1 0 Proline-rich protein family 20 Asp PF00026.21 001171078.1_37923001_3 - 6.9e-123 409.9 3.3 8.2e-123 409.7 3.3 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001171078.1_37923001_3 - 1.5e-15 57.8 0.5 2.1e-12 47.6 0.5 2.5 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001171078.1_37923001_3 - 1.1e-10 40.9 1.0 2.1e-10 40.1 1.0 1.4 1 0 0 1 1 1 1 A1 Propeptide Asp_protease_2 PF13650.4 001171078.1_37923001_3 - 0.00014 22.3 0.1 0.029 14.9 0.0 2.5 2 0 0 2 2 2 2 Aspartyl protease LSM PF01423.20 030145.3_32928001_3 - 9.9e-18 63.5 0.1 1.5e-17 62.9 0.1 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.4 030145.3_32928001_3 - 0.0023 17.9 0.0 0.0043 17.1 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain F-box PF00646.31 033484.2_26224001_3 - 1.4e-07 31.1 0.3 3.8e-07 29.7 0.3 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.5 033484.2_26224001_3 - 4.4e-07 29.6 1.5 9.4e-07 28.5 1.5 1.6 1 0 0 1 1 1 1 F-box-like Elongin_A PF06881.9 033484.2_26224001_3 - 0.095 13.1 0.1 15 6.0 0.0 2.4 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Vta1 PF04652.14 001133194.1_43527001_3 - 8.2e-50 168.4 1.4 2e-49 167.2 1.2 1.7 2 0 0 2 2 2 1 Vta1 like Lectin_C PF00059.19 001195376.1_29622001_1 - 1.6e-23 83.3 0.0 2.1e-23 83.0 0.0 1.1 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 001195376.1_29622001_1 - 8.7e-11 41.3 32.4 7e-06 25.6 14.9 2.4 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) ST7 PF04184.10 001195317.1_39525001_1 - 0 1021.9 3.0 0 1021.1 3.0 1.3 1 1 0 1 1 1 1 ST7 protein TPR_6 PF13174.4 001195317.1_39525001_1 - 0.0012 19.2 0.0 0.0047 17.3 0.0 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.15 001195317.1_39525001_1 - 0.016 15.1 0.2 6.9 6.9 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Clathrin PF00637.18 001195317.1_39525001_1 - 0.099 12.4 0.1 0.19 11.4 0.1 1.4 1 0 0 1 1 1 0 Region in Clathrin and VPS TPR_19 PF14559.4 001195317.1_39525001_1 - 0.31 11.5 4.5 0.55 10.6 0.3 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.4 001195317.1_39525001_1 - 0.32 11.8 3.2 19 6.3 0.1 4.2 3 1 1 4 4 4 0 Tetratricopeptide repeat zf-HIT PF04438.14 001195418.1_29621001_3 - 3.4e-09 36.3 11.6 3.4e-09 36.3 11.6 1.8 1 1 0 1 1 1 1 HIT zinc finger zf-MYND PF01753.16 001195418.1_29621001_3 - 0.098 12.6 10.8 0.19 11.7 10.8 1.5 1 0 0 1 1 1 0 MYND finger FGGY_C PF02782.14 001195418.1_29621001_3 - 0.18 11.4 0.0 0.22 11.1 0.0 1.1 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Ras PF00071.20 001133210.1_43528001_1 - 7.2e-64 214.1 0.2 9.7e-64 213.7 0.2 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001133210.1_43528001_1 - 4.9e-33 113.8 0.2 6.9e-33 113.3 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001133210.1_43528001_1 - 9.8e-14 51.0 0.1 1.4e-13 50.5 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001133210.1_43528001_1 - 0.00026 20.3 0.1 0.00036 19.8 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.25 001133210.1_43528001_1 - 0.00048 19.6 0.0 0.00073 19.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.8 001133210.1_43528001_1 - 0.027 13.8 0.0 0.041 13.2 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.21 001133210.1_43528001_1 - 0.067 13.2 0.1 0.1 12.5 0.1 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase tRNA-synt_1 PF00133.20 001133767.1_43529001_3 - 1.1e-44 152.6 3.0 6.3e-25 87.3 4.1 5.8 3 1 0 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.9 001133767.1_43529001_3 - 4.7e-30 104.5 0.0 2.1e-19 69.5 0.0 3.3 3 0 0 3 3 3 3 tRNA synthetases class I (M) Anticodon_1 PF08264.11 001133767.1_43529001_3 - 4.8e-12 46.0 0.0 8.9e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1_2 PF13603.4 001133767.1_43529001_3 - 3.1e-08 33.2 0.0 2.7e-06 26.9 0.0 2.3 1 1 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.17 001133767.1_43529001_3 - 0.0033 16.7 0.0 1.5 8.0 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.16 001133767.1_43529001_3 - 0.0096 14.7 0.0 0.8 8.4 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (K) Ribosomal_S30 PF04758.12 001190436.1_32922001_3 - 1.5e-30 105.0 12.9 2.7e-30 104.2 12.9 1.4 1 0 0 1 1 1 1 Ribosomal protein S30 ubiquitin PF00240.21 001190436.1_32922001_3 - 1.6e-14 53.2 0.0 2.3e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 001190436.1_32922001_3 - 0.0012 18.5 0.0 0.002 17.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like IP_trans PF02121.16 001133087.1_43526001_2 - 8.7e-117 388.9 1.2 1.1e-116 388.5 1.2 1.1 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein Globin PF00042.20 001168817.1_40422001_2 - 5.1e-24 84.8 0.0 7.3e-24 84.3 0.0 1.2 1 0 0 1 1 1 1 Globin Pkinase PF00069.23 001131871.1_43528001_2 - 2.2e-26 92.7 0.0 3e-26 92.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001131871.1_43528001_2 - 6.8e-16 58.2 0.0 8.7e-16 57.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 001131871.1_43528001_2 - 0.0022 17.8 0.0 0.005 16.6 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.9 001131871.1_43528001_2 - 0.14 10.9 0.2 0.22 10.3 0.2 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Mito_carr PF00153.25 001171077.1_37923001_3 - 6.9e-54 179.6 0.6 2.8e-17 62.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein TFIIE_beta PF02186.13 001167922.1_32924001_2 - 4.4e-24 84.4 1.3 1e-23 83.2 0.2 2.1 2 0 0 2 2 2 1 TFIIE beta subunit core domain Fcf1 PF04900.10 028632.2_32922001_1 - 1e-39 134.8 1.9 1e-39 134.8 1.9 1.5 2 0 0 2 2 2 1 Fcf1 OAD_gamma PF04277.11 001132272.2_43527001_1 - 1.3 9.5 4.9 2.4 8.7 4.9 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Aurora-A_bind PF09041.8 001132272.2_43527001_2 - 4.3e-38 129.1 0.2 1.1e-37 127.7 0.2 1.8 1 0 0 1 1 1 1 Aurora-A binding TPX2_importin PF12214.6 001132272.2_43527001_2 - 1.2e-36 126.3 27.8 2.3e-36 125.4 8.6 8.1 4 2 4 8 8 8 4 Cell cycle regulated microtubule associated protein TPX2 PF06886.9 001132272.2_43527001_2 - 1.8e-11 44.0 21.8 1.8e-11 44.0 21.8 8.4 10 0 0 10 10 10 1 Targeting protein for Xklp2 (TPX2) DUF4604 PF15377.4 001132272.2_43527001_3 - 0.28 11.5 14.1 0.42 10.9 14.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Pkinase PF00069.23 172461.3_32926001_1 - 5.2e-60 202.9 0.0 8.7e-60 202.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 172461.3_32926001_1 - 1.6e-45 155.3 0.0 2.7e-45 154.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 172461.3_32926001_1 - 0.027 14.2 0.7 0.24 11.2 0.0 2.5 2 1 1 3 3 3 0 Phosphotransferase enzyme family DUF2951 PF11166.6 172461.3_32926001_1 - 0.66 10.1 4.1 0.7 10.0 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) NARP1 PF12569.6 001133480.1_43529001_2 - 4.3e-219 728.5 23.3 4.3e-219 728.5 23.3 1.5 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_2 PF07719.15 001133480.1_43529001_2 - 1.3e-11 43.5 22.6 0.00081 19.2 0.1 8.6 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.4 001133480.1_43529001_2 - 9.9e-08 32.4 5.6 0.49 11.0 0.0 5.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.4 001133480.1_43529001_2 - 1.2e-07 31.8 10.5 9.5 7.2 0.1 8.6 7 3 3 10 10 8 0 Tetratricopeptide repeat TPR_19 PF14559.4 001133480.1_43529001_2 - 2.8e-07 30.8 18.4 0.069 13.5 0.2 6.5 5 1 2 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.4 001133480.1_43529001_2 - 5.4e-07 29.2 18.9 0.00058 19.8 0.1 8.0 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_1 PF00515.26 001133480.1_43529001_2 - 2.6e-06 26.9 20.0 0.004 16.8 0.2 8.3 8 0 0 8 8 8 2 Tetratricopeptide repeat ANAPC3 PF12895.5 001133480.1_43529001_2 - 1.1e-05 25.4 22.0 0.0014 18.6 0.9 5.5 3 2 3 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.4 001133480.1_43529001_2 - 3.9e-05 23.1 0.7 0.0004 19.9 0.1 3.3 3 0 0 3 3 3 1 TPR repeat TPR_9 PF13371.4 001133480.1_43529001_2 - 0.00014 21.8 2.8 0.55 10.3 0.2 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.4 001133480.1_43529001_2 - 0.0033 16.5 4.1 0.0033 16.5 4.1 3.4 2 2 2 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.4 001133480.1_43529001_2 - 0.0089 16.2 20.8 1.2 9.3 0.1 6.6 6 2 1 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.4 001133480.1_43529001_2 - 0.034 14.4 2.7 6.6 7.2 0.0 5.4 5 0 0 5 5 4 0 Tetratricopeptide repeat DUF3922 PF13059.4 001133480.1_43529001_2 - 0.1 13.0 1.6 0.43 11.0 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3992) Peptidase_S30 PF01577.14 001133480.1_43529001_2 - 0.81 9.1 9.2 1.4 8.4 9.2 1.3 1 0 0 1 1 1 0 Potyvirus P1 protease TPR_7 PF13176.4 001133480.1_43529001_2 - 1.1 9.3 14.7 1.3 9.0 0.1 6.2 8 0 0 8 8 7 0 Tetratricopeptide repeat F-protein PF00469.18 001133480.1_43529001_2 - 2.2 7.7 7.0 2.1 7.8 5.5 1.6 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef Fis1_TPR_C PF14853.4 001133480.1_43529001_2 - 2.9 7.9 7.2 38 4.3 0.1 4.3 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat Glyco_hydro_99 PF16317.3 001133788.1_43529001_1 - 1.5e-189 629.2 12.3 1.8e-189 628.9 12.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 99 Lipoprotein_Ltp PF07553.9 001133788.1_43529001_1 - 0.001 19.1 0.0 0.0021 18.2 0.0 1.4 1 0 0 1 1 1 1 Host cell surface-exposed lipoprotein MAPKK1_Int PF08923.8 001134202.1_43528001_3 - 2.1e-47 159.7 0.0 3.3e-47 159.0 0.0 1.3 1 0 0 1 1 1 1 Mitogen-activated protein kinase kinase 1 interacting 7tm_1 PF00001.19 001198959.1_37923001_1 - 1.5e-72 244.0 14.3 2e-72 243.5 14.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 001198959.1_37923001_1 - 4.4e-11 42.5 9.9 2.1e-10 40.3 9.9 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.7 001198959.1_37923001_1 - 1.9e-07 30.6 10.0 1.9e-07 30.6 10.0 2.5 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Voltage_CLC PF00654.18 001172693.1_09925001_1 - 3.2e-108 362.0 21.6 4.5e-108 361.5 21.6 1.2 1 0 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.26 001172693.1_09925001_1 - 3.7e-13 49.6 0.6 6.6e-07 29.6 0.1 2.5 2 0 0 2 2 2 2 CBS domain Kinesin PF00225.21 008444.4_32929001_1 - 1.2e-121 405.6 0.4 1.2e-121 405.6 0.4 1.7 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.3 008444.4_32929001_1 - 3.7e-28 98.2 0.0 7.5e-28 97.2 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding Kinesin_assoc PF16183.3 008444.4_32929001_1 - 0.063 13.3 0.1 0.063 13.3 0.1 2.5 2 0 0 2 2 2 0 Kinesin-associated DUF948 PF06103.9 008444.4_32929001_1 - 1.6 8.9 6.5 1.1 9.4 3.3 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) LAMTOR PF15454.4 001132939.1_43523001_1 - 3.1e-20 72.4 0.3 5.2e-20 71.7 0.3 1.3 1 0 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Metallothio PF00131.18 001082220.2_37921001_3 - 2.1e-20 72.5 61.3 2.5e-20 72.2 61.3 1.1 1 0 0 1 1 1 1 Metallothionein SNF PF00209.16 001133974.1_43528001_1 - 3.2e-222 738.7 33.1 4.4e-222 738.3 33.1 1.2 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Selenoprotein_S PF06936.9 001164113.1_49822001_2 - 3.4e-92 307.4 0.7 4.3e-92 307.1 0.7 1.0 1 0 0 1 1 1 1 Selenoprotein S (SelS) Flavodoxin_2 PF02525.15 001172986.1_09923001_3 - 8.7e-51 172.3 0.0 1.3e-50 171.8 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.13 001172986.1_09923001_3 - 1.4e-09 37.8 0.0 2.6e-09 36.8 0.0 1.4 1 1 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_4 PF12682.5 001172986.1_09923001_3 - 0.011 15.3 0.1 0.043 13.3 0.1 1.9 1 1 0 1 1 1 0 Flavodoxin FAD_binding_1 PF00667.18 001173002.1_09925001_2 - 4.4e-87 291.2 0.0 6.5e-87 290.6 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.23 001173002.1_09925001_2 - 9.7e-39 132.7 0.2 4.1e-38 130.7 0.3 2.0 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.19 001173002.1_09925001_2 - 1.9e-18 67.0 0.0 5.7e-18 65.4 0.0 1.9 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain ETF PF01012.19 001131899.2_43523001_2 - 1.3e-39 135.9 1.2 1.9e-39 135.3 1.2 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.17 001131899.2_43523001_2 - 1.2e-36 124.4 0.4 3.6e-36 122.9 0.4 1.8 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain F_actin_cap_B PF01115.15 001134166.1_43524001_3 - 3.3e-110 367.2 0.0 4.3e-110 366.9 0.0 1.1 1 0 0 1 1 1 1 F-actin capping protein, beta subunit SAM_1 PF00536.28 025976.5_32927001_2 - 9.9e-09 35.4 0.0 1.6e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-C3HC4_4 PF15227.4 025976.5_32927001_2 - 6.7e-08 32.4 12.4 6.7e-08 32.4 12.4 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 025976.5_32927001_2 - 7.6e-08 32.0 14.3 7.6e-08 32.0 14.3 2.5 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 025976.5_32927001_2 - 2.9e-07 30.1 14.2 2.9e-07 30.1 14.2 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 025976.5_32927001_2 - 2.9e-06 26.9 8.4 2.9e-06 26.9 8.4 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 025976.5_32927001_2 - 4e-05 23.7 15.2 4e-05 23.7 15.2 2.8 3 0 0 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.4 025976.5_32927001_2 - 9.9e-05 22.1 12.6 9.9e-05 22.1 12.6 2.6 2 0 0 2 2 2 1 RING-type zinc-finger SAM_2 PF07647.15 025976.5_32927001_2 - 0.00024 21.0 0.0 0.0004 20.3 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.14 025976.5_32927001_2 - 0.012 15.4 0.0 0.03 14.1 0.0 1.6 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain zf-ANAPC11 PF12861.5 025976.5_32927001_2 - 0.1 12.5 5.6 0.26 11.2 5.6 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.5 025976.5_32927001_2 - 0.11 12.6 11.3 0.34 11.1 11.3 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_10 PF16685.3 025976.5_32927001_2 - 0.16 12.0 6.6 0.4 10.7 6.6 1.7 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_5 PF14634.4 025976.5_32927001_2 - 2.4 8.1 19.8 0.066 13.1 12.3 2.4 2 0 0 2 2 2 0 zinc-RING finger domain Asp PF00026.21 001171079.1_37923001_3 - 7.4e-123 409.8 6.9 8.8e-123 409.6 6.9 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001171079.1_37923001_3 - 7.2e-17 62.1 1.5 2.2e-14 54.0 1.5 2.5 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.10 001171079.1_37923001_3 - 1.1e-10 41.0 1.8 2e-10 40.2 1.8 1.4 1 0 0 1 1 1 1 A1 Propeptide Tetraspannin PF00335.18 001134305.1_39522001_1 - 1.6e-51 175.0 15.8 1.8e-51 174.8 15.8 1.0 1 0 0 1 1 1 1 Tetraspanin family Baculo_11_kDa PF06143.9 001134305.1_39522001_1 - 0.033 13.6 3.1 0.083 12.3 3.1 1.6 1 0 0 1 1 1 0 Baculovirus 11 kDa family DUF4212 PF13937.4 001134305.1_39522001_1 - 0.094 13.0 0.7 0.094 13.0 0.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4212) OppC_N PF12911.5 001134305.1_39522001_1 - 0.2 11.6 3.1 5.6 6.9 1.5 2.7 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C MARVEL PF01284.21 001134305.1_39522001_1 - 2 8.3 16.6 0.27 11.1 12.8 1.7 2 1 0 2 2 2 0 Membrane-associating domain DUF2207 PF09972.7 001134305.1_39522001_1 - 3 6.4 11.3 16 4.0 8.7 2.3 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) DZF PF07528.12 001132083.1_43524001_2 - 3e-95 318.4 0.0 4e-95 318.0 0.0 1.2 1 0 0 1 1 1 1 DZF domain PIG-P PF08510.10 001133929.1_43527001_1 - 3e-38 130.3 2.3 5e-38 129.6 2.3 1.4 1 0 0 1 1 1 1 PIG-P DPM2 PF07297.10 001133929.1_43527001_1 - 0.013 15.7 5.7 0.027 14.6 5.7 1.5 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) 7tm_1 PF00001.19 001172989.1_09923001_2 - 2e-37 128.8 15.0 2.5e-37 128.4 15.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 001172989.1_09923001_2 - 3.2e-05 23.2 4.3 3.2e-05 23.2 4.3 2.1 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw Cytochrom_B_N_2 PF13631.4 001172989.1_09923001_2 - 0.00032 20.6 0.6 0.00094 19.1 0.1 2.0 2 0 0 2 2 2 1 Cytochrome b(N-terminal)/b6/petB 7TM_GPCR_Srv PF10323.7 001172989.1_09923001_2 - 0.00078 18.7 11.3 0.0017 17.7 10.9 1.7 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.7 001172989.1_09923001_2 - 0.0019 17.5 6.9 0.45 9.7 2.5 2.3 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001172989.1_09923001_2 - 0.15 11.6 9.4 2.7 7.5 9.4 2.0 1 1 0 1 1 1 0 Olfactory receptor DUF4190 PF13828.4 001172989.1_09923001_2 - 1.9 8.2 6.7 0.3 10.7 0.8 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4190) 7TM_GPCR_Sru PF10322.7 001172989.1_09923001_2 - 2.6 7.1 12.7 0.053 12.7 4.2 2.2 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Sru LTV PF04180.12 001135512.1_43524001_3 - 1.5e-85 288.1 22.5 6.6e-85 286.0 22.5 1.9 1 1 0 1 1 1 1 Low temperature viability protein DUF1874 PF08960.8 001135512.1_43524001_3 - 3.1 7.9 4.9 1.7 8.7 2.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1874) ubiquitin PF00240.21 001171381.1_37921001_1 - 4.8e-21 74.1 0.1 6.7e-21 73.7 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 001171381.1_37921001_1 - 6.8e-10 38.5 0.0 1.1e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 001171381.1_37921001_1 - 0.0037 17.7 0.1 0.0067 16.8 0.1 1.4 1 1 0 1 1 1 1 DUF2407 ubiquitin-like domain DUF2870 PF11069.6 001171381.1_37921001_1 - 0.11 12.8 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2870) UN_NPL4 PF11543.6 001171381.1_37921001_1 - 0.11 12.9 0.0 0.2 12.0 0.0 1.4 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 TPR_1 PF00515.26 001107752.2_45729001_1 - 1.4e-23 81.6 5.0 0.00036 20.1 0.0 7.9 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.15 001107752.2_45729001_1 - 8.2e-23 78.5 2.4 0.00082 19.2 0.0 7.5 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_11 PF13414.4 001107752.2_45729001_1 - 1.3e-12 47.0 0.7 0.057 13.0 0.0 6.5 5 1 1 6 6 6 4 TPR repeat TPR_8 PF13181.4 001107752.2_45729001_1 - 1.5e-12 46.5 0.6 0.017 15.2 0.0 6.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.4 001107752.2_45729001_1 - 5.8e-12 45.6 12.5 0.074 13.2 1.5 7.3 6 2 1 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.4 001107752.2_45729001_1 - 2.8e-10 39.3 7.0 0.083 12.8 0.0 6.7 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_14 PF13428.4 001107752.2_45729001_1 - 1e-05 25.8 6.4 0.94 10.3 0.1 6.7 6 2 2 8 8 8 1 Tetratricopeptide repeat TPR_9 PF13371.4 001107752.2_45729001_1 - 0.00011 22.1 0.4 0.78 9.8 0.0 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.4 001107752.2_45729001_1 - 0.00081 19.1 14.8 0.82 9.5 0.0 6.7 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.4 001107752.2_45729001_1 - 0.0011 19.3 4.8 0.57 10.6 0.3 4.5 3 2 1 5 5 5 1 Tetratricopeptide repeat ChAPs PF09295.8 001107752.2_45729001_1 - 0.002 17.1 1.9 0.0045 15.9 0.3 2.3 3 0 0 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_16 PF13432.4 001107752.2_45729001_1 - 0.0038 17.8 3.4 0.15 12.6 0.6 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.4 001107752.2_45729001_1 - 0.15 12.6 0.3 15 6.4 0.1 3.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.4 001107752.2_45729001_1 - 0.19 12.1 8.2 28 5.3 0.2 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.5 001107752.2_45729001_1 - 0.38 10.9 3.1 3.2 7.9 0.0 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 SQS_PSY PF00494.17 001133004.2_43524001_2 - 2.4e-41 141.8 0.0 3.1e-41 141.5 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase Octopine_DH PF02317.15 001133004.2_43524001_2 - 0.069 13.1 0.3 0.22 11.4 0.0 1.9 2 0 0 2 2 2 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain FAD_binding_1 PF00667.18 001160290.1_37925001_1 - 6.9e-83 277.4 0.0 1e-82 276.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.23 001160290.1_37925001_1 - 5.8e-40 136.7 0.3 2.8e-39 134.5 0.5 2.1 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.19 001160290.1_37925001_1 - 6.5e-17 62.0 0.0 2.4e-16 60.2 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain SNF PF00209.16 001173018.1_09925001_1 - 1.5e-227 756.3 39.6 1.7e-227 756.1 39.6 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family 5HT_transport_N PF03491.11 001173018.1_09925001_1 - 1.4e-21 76.2 2.7 1.4e-21 76.2 2.7 1.7 2 0 0 2 2 2 1 Serotonin (5-HT) neurotransmitter transporter, N-terminus Pkinase PF00069.23 001167633.1_49824001_1 - 2.6e-75 253.1 0.0 3.5e-75 252.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001167633.1_49824001_1 - 4.4e-42 144.0 0.0 6.2e-42 143.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.3 001167633.1_49824001_1 - 2.8e-13 50.2 0.1 1e-12 48.4 0.0 2.0 2 0 0 2 2 2 1 Adenylate sensor of SNF1-like protein kinase Kinase-like PF14531.4 001167633.1_49824001_1 - 1.6e-05 24.2 0.0 2.9e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 001167633.1_49824001_1 - 0.002 17.6 0.2 0.0037 16.7 0.2 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.12 001167633.1_49824001_1 - 0.0039 16.4 0.1 0.008 15.4 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001167633.1_49824001_1 - 0.052 13.3 0.2 0.15 11.8 0.2 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family zf-HIT PF04438.14 001194929.1_39722001_1 - 6e-09 35.5 11.4 6e-09 35.5 11.4 1.6 1 1 0 1 1 1 1 HIT zinc finger zf-MYND PF01753.16 001194929.1_39722001_1 - 0.26 11.3 10.9 0.49 10.4 10.9 1.4 1 0 0 1 1 1 0 MYND finger Guanylate_cyc PF00211.18 012770.2_45725001_3 - 3.1e-69 232.1 0.1 5.2e-69 231.4 0.1 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOB PF07700.13 012770.2_45725001_3 - 5e-48 163.0 0.2 8.6e-48 162.2 0.2 1.4 1 0 0 1 1 1 1 Haem-NO-binding HNOBA PF07701.12 012770.2_45725001_3 - 3e-45 154.2 8.8 8e-45 152.8 8.8 1.7 1 1 0 1 1 1 1 Heme NO binding associated Bac_DNA_binding PF00216.19 012770.2_45725001_3 - 0.081 13.0 0.3 11 6.2 0.2 2.6 2 0 0 2 2 2 0 Bacterial DNA-binding protein YadA_stalk PF05662.12 012770.2_45725001_3 - 0.18 11.4 0.7 0.47 10.1 0.7 1.7 1 0 0 1 1 1 0 Coiled stalk of trimeric autotransporter adhesin Mito_carr PF00153.25 001281332.1_31322001_1 - 1.4e-56 188.3 1.3 7.1e-18 64.2 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein F-actin_cap_A PF01267.15 001242733.1_37625001_1 - 4.3e-106 354.1 2.9 5.3e-106 353.8 2.9 1.1 1 0 0 1 1 1 1 F-actin capping protein alpha subunit PH PF00169.27 001281544.1_31325001_1 - 4.6e-22 78.4 1.3 1.2e-21 77.1 0.2 2.2 2 0 0 2 2 2 1 PH domain PH_11 PF15413.4 001281544.1_31325001_1 - 1.3e-06 28.6 1.7 7.2e-06 26.2 1.7 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.4 001281544.1_31325001_1 - 0.018 15.0 0.9 0.14 12.2 0.9 2.1 1 1 0 1 1 1 0 PH domain PH_8 PF15409.4 001281544.1_31325001_1 - 0.019 15.1 0.2 0.043 14.0 0.2 1.6 1 1 0 1 1 1 0 Pleckstrin homology domain PH_9 PF15410.4 001281544.1_31325001_1 - 0.13 12.5 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain LRR_6 PF13516.4 001283410.1_29527001_3 - 4e-19 66.8 26.2 2.5e-05 23.9 0.7 7.4 8 0 0 8 8 8 5 Leucine Rich repeat LRR_4 PF12799.5 001283410.1_29527001_3 - 4.6e-06 26.7 15.8 0.023 14.9 0.9 4.8 4 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.31 001283410.1_29527001_3 - 0.029 14.7 9.9 55 4.7 0.0 6.9 7 0 0 7 7 7 0 Leucine Rich Repeat LRR_8 PF13855.4 001283410.1_29527001_3 - 0.1 12.2 18.4 6.3 6.5 6.1 5.4 4 1 1 5 5 5 0 Leucine rich repeat Pkinase PF00069.23 001281632.1_31328001_3 - 2.7e-51 174.3 0.0 5.1e-51 173.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001281632.1_31328001_3 - 6.9e-24 84.4 0.0 1.1e-23 83.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 001281632.1_31328001_3 - 6.9e-07 28.7 0.0 9.1e-05 21.8 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 001281632.1_31328001_3 - 0.0082 16.0 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.9 001281632.1_31328001_3 - 0.022 13.6 0.1 0.033 13.0 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase PMP22_Claudin PF00822.18 001283222.1_29524001_3 - 4.1e-50 169.8 0.7 9.6e-50 168.6 0.7 1.6 2 1 0 2 2 2 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 001283222.1_29524001_3 - 1.4e-19 70.5 0.5 2.4e-19 69.7 0.5 1.4 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction LRR_9 PF14580.4 001283343.1_29526001_1 - 3.5e-94 313.1 1.6 4.8e-94 312.6 1.6 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.5 001283343.1_29526001_1 - 4.4e-06 26.8 7.1 0.0033 17.6 2.4 2.9 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.4 001283343.1_29526001_1 - 6.1e-05 22.6 3.1 0.00015 21.3 2.2 2.0 1 1 1 2 2 2 2 Leucine rich repeat MEA1 PF06910.9 001283914.1_29522001_1 - 6.3e-118 390.4 9.2 7.5e-118 390.2 9.2 1.0 1 0 0 1 1 1 1 Male enhanced antigen 1 (MEA1) Pkinase PF00069.23 001034089.2_39725001_1 - 1.2e-69 234.5 0.0 1.5e-69 234.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001034089.2_39725001_1 - 1.1e-28 100.1 0.0 1.6e-28 99.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 001034089.2_39725001_1 - 0.00051 19.9 0.1 0.0012 18.7 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.4 001034089.2_39725001_1 - 0.0036 16.5 0.0 0.0066 15.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.12 001034089.2_39725001_1 - 0.033 13.4 0.0 0.053 12.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4023 PF13215.4 001034089.2_39725001_1 - 0.16 11.9 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4023) WH1 PF00568.21 001282022.1_32925001_1 - 3.4e-36 123.4 0.0 5.5e-36 122.8 0.0 1.2 1 0 0 1 1 1 1 WH1 domain VASP_tetra PF08776.9 001282022.1_32925001_1 - 2.4e-16 58.8 11.8 4.2e-16 58.1 11.8 1.4 1 0 0 1 1 1 1 VASP tetramerisation domain ASD2 PF08687.9 001282022.1_32925001_1 - 0.025 14.0 3.7 0.035 13.6 3.7 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Ran_BP1 PF00638.16 001282022.1_32925001_1 - 0.089 12.9 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 RanBP1 domain Endosulfine PF04667.15 021842.3_45723001_3 - 2.9e-08 33.6 5.9 6.9e-08 32.4 5.9 1.7 1 1 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Globin PF00042.20 001283367.1_29522001_3 - 4.5e-32 110.8 0.1 6.8e-31 107.0 0.0 2.0 2 0 0 2 2 2 1 Globin BCA_ABC_TP_C PF12399.6 001283367.1_29522001_3 - 0.077 12.8 0.5 2.6 7.9 0.0 2.4 2 0 0 2 2 2 0 Branched-chain amino acid ATP-binding cassette transporter Mito_carr PF00153.25 001280694.1_39524001_3 - 5.5e-58 192.8 1.7 4.1e-20 71.4 0.1 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein DUF4531 PF15041.4 001285243.1_29522001_1 - 2.8e-107 356.7 14.2 3.4e-107 356.4 14.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4531) CIA30 PF08547.10 001279652.1_24222001_1 - 1.4e-51 174.5 0.4 2e-51 174.0 0.4 1.2 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) CBM_11 PF03425.11 001279652.1_24222001_1 - 0.00036 20.3 0.3 0.0007 19.4 0.1 1.7 2 1 0 2 2 2 1 Carbohydrate binding domain (family 11) MISS PF15822.3 001284585.1_29525001_1 - 4.4e-119 396.5 124.8 4.4e-119 396.5 124.8 1.9 2 0 0 2 2 2 1 MAPK-interacting and spindle-stabilising protein-like Casein PF00363.16 214434.2_49823001_1 - 1.4e-23 83.2 11.9 1.4e-23 83.2 11.9 2.8 2 2 0 2 2 2 1 Casein DUF948 PF06103.9 214434.2_49823001_1 - 0.15 12.2 0.1 0.23 11.6 0.1 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Pkinase PF00069.23 001281659.1_31323001_1 - 2.8e-73 246.4 0.0 1.6e-64 217.7 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 001281659.1_31323001_1 - 3.8e-35 121.3 0.0 5.7e-35 120.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.4 001281659.1_31323001_1 - 0.0066 15.7 0.1 0.6 9.2 0.0 2.9 3 0 0 3 3 3 1 Kinase-like APH PF01636.21 001281659.1_31323001_1 - 0.02 14.7 0.0 0.031 14.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF4551 PF15087.4 001284593.1_29525001_1 - 7.3e-222 738.4 9.7 8.3e-222 738.3 9.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4551) zf-C4H2 PF10146.7 001243804.1_26226001_1 - 1.7e-74 250.3 19.4 2.2e-74 250.0 19.4 1.1 1 0 0 1 1 1 1 Zinc finger-containing protein Sec20 PF03908.11 001243804.1_26226001_1 - 0.041 13.7 0.1 0.086 12.6 0.1 1.5 1 0 0 1 1 1 0 Sec20 Spc7 PF08317.9 001243804.1_26226001_1 - 0.12 11.1 9.1 0.17 10.6 9.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein NUDE_C PF04880.11 001243804.1_26226001_1 - 0.26 11.6 4.1 0.53 10.6 4.1 1.5 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region CENP-O PF09496.8 001243804.1_26226001_1 - 0.35 10.7 1.9 0.53 10.1 1.9 1.2 1 0 0 1 1 1 0 Cenp-O kinetochore centromere component TNF PF00229.16 001267755.1_08022001_2 - 5.2e-29 100.6 0.1 1.2e-28 99.5 0.0 1.6 2 0 0 2 2 2 1 TNF(Tumour Necrosis Factor) family Proteasom_PSMB PF10508.7 001285116.1_29524001_1 - 1.2e-203 677.1 0.1 1.3e-203 676.9 0.1 1.0 1 0 0 1 1 1 1 Proteasome non-ATPase 26S subunit RICTOR_V PF14668.4 001285116.1_29524001_1 - 7.7e-06 25.9 1.2 2.5 8.2 0.1 3.7 3 0 0 3 3 3 3 Rapamycin-insensitive companion of mTOR, domain 5 Cnd1 PF12717.5 001285116.1_29524001_1 - 1.3e-05 25.2 1.8 0.25 11.2 0.0 3.6 1 1 2 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.4 001285116.1_29524001_1 - 0.0011 19.2 0.9 0.1 12.9 0.0 4.1 4 2 0 5 5 5 1 HEAT repeats V-ATPase_H_C PF11698.6 001285116.1_29524001_1 - 0.0015 18.5 0.5 0.68 10.0 0.1 3.2 3 0 0 3 3 3 2 V-ATPase subunit H Ribosomal_L3 PF00297.20 001244063.1_49823001_1 - 1.8e-194 645.7 10.3 2.2e-194 645.4 10.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 DUF4939 PF16297.3 001278534.1_32929001_2 - 2.2e-11 43.5 0.0 4.4e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Retrotrans_gag PF03732.15 001278534.1_32929001_2 - 3.6e-09 36.7 0.0 6.2e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon gag protein Nop14 PF04147.10 001278534.1_32929001_2 - 0.13 10.4 37.2 0.18 9.8 37.2 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.12 001278534.1_32929001_2 - 0.16 10.1 24.6 0.23 9.6 24.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Lin-8 PF03353.13 001278534.1_32929001_2 - 0.48 9.8 22.7 0.72 9.2 22.7 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist IFT57 PF10498.7 001278534.1_32929001_2 - 0.54 9.1 24.4 0.95 8.2 24.4 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 SDA1 PF05285.10 001278534.1_32929001_2 - 0.62 9.3 36.0 0.97 8.7 36.0 1.2 1 0 0 1 1 1 0 SDA1 DUF2457 PF10446.7 001278534.1_32929001_2 - 2 7.3 38.2 4.5 6.2 38.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RNA_pol_Rpc4 PF05132.12 001278534.1_32929001_2 - 5.6 7.3 6.8 13 6.1 6.8 1.6 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF1510 PF07423.9 001278534.1_32929001_2 - 8.2 5.7 32.6 14 4.9 32.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) HMG-CoA_red PF00368.16 001281702.1_31326001_1 - 2.2e-146 487.5 0.6 3e-146 487.0 0.6 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Sterol-sensing PF12349.6 001281702.1_31326001_1 - 2.6e-17 62.9 3.5 5.4e-17 61.9 3.5 1.5 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.16 001281702.1_31326001_1 - 1.1e-08 33.5 3.6 1.8e-08 32.9 3.6 1.2 1 0 0 1 1 1 1 Patched family DHFR_1 PF00186.17 001244064.1_49824001_3 - 3.7e-34 117.6 0.0 4.9e-34 117.2 0.0 1.1 1 0 0 1 1 1 1 Dihydrofolate reductase ATP-sulfurylase PF01747.15 001289479.1_32926001_1 - 4.4e-71 238.6 0.1 6e-71 238.2 0.1 1.2 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.18 001289479.1_32926001_1 - 5.9e-70 234.1 0.0 1.1e-69 233.3 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.4 001289479.1_32926001_1 - 1.6e-48 164.2 0.0 2.8e-48 163.5 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain AAA_33 PF13671.4 001289479.1_32926001_1 - 1.6e-06 28.2 0.0 3.1e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain zf-RING-like PF08746.9 001289479.1_32926001_1 - 0.01 16.0 1.1 0.01 16.0 1.1 2.6 3 0 0 3 3 3 1 RING-like domain AAA_18 PF13238.4 001289479.1_32926001_1 - 0.044 14.2 0.0 0.16 12.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.15 001289479.1_32926001_1 - 0.072 12.6 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 Thymidylate kinase EF1_GNE PF00736.17 001285431.1_32924001_3 - 2.5e-36 123.6 0.4 5.3e-36 122.5 0.4 1.5 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.7 001285431.1_32924001_3 - 1.9e-12 47.2 10.5 1.9e-12 47.2 10.5 1.9 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region JIP_LZII PF16471.3 001285431.1_32924001_3 - 0.0012 18.9 0.9 0.0028 17.7 0.9 1.6 1 0 0 1 1 1 1 JNK-interacting protein leucine zipper II Striatin PF08232.10 001285431.1_32924001_3 - 0.017 15.6 2.9 0.027 14.9 2.9 1.2 1 0 0 1 1 1 0 Striatin family Trimer_CC PF08954.9 001285431.1_32924001_3 - 0.034 13.6 1.3 0.21 11.1 0.0 2.8 3 0 0 3 3 3 0 Trimerisation motif TSC22 PF01166.16 001285431.1_32924001_3 - 0.07 13.3 0.2 7.9 6.8 0.1 2.6 1 1 1 2 2 2 0 TSC-22/dip/bun family KASH_CCD PF14662.4 001285431.1_32924001_3 - 0.093 12.4 1.4 0.3 10.8 0.1 2.1 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH PilJ PF13675.4 001285431.1_32924001_3 - 0.14 12.1 0.2 0.37 10.7 0.2 1.7 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term MinC_N PF05209.11 001285431.1_32924001_3 - 0.18 11.6 0.1 2.7 7.9 0.0 2.2 2 0 0 2 2 2 0 Septum formation inhibitor MinC, N-terminal domain PRKG1_interact PF15898.3 001285431.1_32924001_3 - 0.25 12.2 3.8 0.64 10.8 3.8 1.6 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Pkinase PF00069.23 001097507.2_49825001_3 - 4.9e-51 173.5 0.0 7e-51 173.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001097507.2_49825001_3 - 2.7e-24 85.7 0.0 4.4e-24 85.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Globin PF00042.20 001266776.2_29622001_3 - 5.9e-28 97.5 0.1 8.5e-28 97.0 0.1 1.2 1 0 0 1 1 1 1 Globin Complex1_30kDa PF00329.17 001279640.1_24222001_1 - 3.6e-45 153.4 0.0 4.8e-45 153.0 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit DUF4570 PF15134.4 001284384.1_32925001_1 - 2.1e-43 146.7 1.2 2.9e-43 146.2 1.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4570) Mito_carr PF00153.25 001284116.1_29524001_2 - 3.5e-70 231.9 0.1 1.3e-23 82.5 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein V_ATPase_I PF01496.17 016920.3_32929001_1 - 0 1129.9 0.1 0 1129.7 0.1 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Asp_protease PF09668.8 001284546.1_29524001_2 - 6.1e-61 203.6 0.5 9.4e-61 203.0 0.5 1.3 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.4 001284546.1_29524001_2 - 1.1e-25 89.8 0.0 1.9e-25 89.1 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.4 001284546.1_29524001_2 - 5.9e-10 39.6 0.0 1e-09 38.8 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease ubiquitin PF00240.21 001284546.1_29524001_2 - 1e-09 37.8 0.0 1.8e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family RVP PF00077.18 001284546.1_29524001_2 - 3.3e-05 24.0 0.0 7.9e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.9 001284546.1_29524001_2 - 5e-05 23.2 0.0 8.4e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease T2SSE_N PF05157.13 001284546.1_29524001_2 - 0.063 13.4 0.1 0.2 11.8 0.0 1.8 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein E, N-terminal domain HSP70 PF00012.18 001284095.1_29524001_2 - 4.9e-115 384.9 0.1 6e-115 384.6 0.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 001284095.1_29524001_2 - 4.3e-11 42.1 0.0 3.5e-10 39.1 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein Actin PF00022.17 001284095.1_29524001_2 - 0.0077 14.7 0.0 0.19 10.2 0.1 2.2 2 0 0 2 2 2 1 Actin ArAE_2 PF10334.7 001284095.1_29524001_2 - 0.083 12.6 0.0 3.4 7.3 0.0 2.2 2 0 0 2 2 2 0 Aromatic acid exporter family member 2 DUF3944 PF13099.4 001284095.1_29524001_2 - 0.38 10.5 1.4 21 4.9 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3944) Globin PF00042.20 001281703.1_31322001_2 - 2.8e-30 105.0 0.0 1e-29 103.1 0.0 1.7 2 0 0 2 2 2 1 Globin F-actin_cap_A PF01267.15 001285329.1_29524001_3 - 6.9e-106 353.4 1.1 8.7e-106 353.1 1.1 1.1 1 0 0 1 1 1 1 F-actin capping protein alpha subunit SNF PF00209.16 001283324.1_29528001_3 - 1e-233 776.6 27.1 1.3e-233 776.3 27.1 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family HMG14_17 PF01101.16 001244114.1_49823001_3 - 3.7e-32 111.0 25.6 5.4e-32 110.5 25.6 1.2 1 0 0 1 1 1 1 HMG14 and HMG17 Tetraspannin PF00335.18 026743.3_32929001_2 - 3.9e-45 154.1 11.2 7.2e-45 153.2 11.2 1.4 1 0 0 1 1 1 1 Tetraspanin family Glyco_hydro_18 PF00704.26 001281337.1_31325001_3 - 1e-79 268.4 0.0 1.3e-79 268.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LSM PF01423.20 001284844.1_29524001_2 - 7.5e-18 63.9 0.7 1.2e-17 63.2 0.7 1.3 1 0 0 1 1 1 1 LSM domain Gemin7 PF11095.6 001284844.1_29524001_2 - 0.0076 16.0 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 Gem-associated protein 7 (Gemin7) Hfq PF17209.1 001284844.1_29524001_2 - 0.053 13.0 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Hfq protein Glyco_hydro_56 PF01630.16 001283703.1_29525001_3 - 6.1e-135 449.4 0.0 7.6e-135 449.1 0.0 1.1 1 0 0 1 1 1 1 Hyaluronidase DUF2180 PF09947.7 001283703.1_29525001_3 - 0.0099 15.7 0.2 0.025 14.4 0.2 1.7 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2180) ADH_N PF08240.10 001244162.1_49823001_1 - 5.2e-23 80.9 0.0 9.6e-23 80.0 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.24 001244162.1_49823001_1 - 1e-21 77.1 0.2 1.6e-21 76.4 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.3 001244162.1_49823001_1 - 4.5e-10 39.2 0.3 9.9e-10 38.1 0.3 1.5 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.19 001244162.1_49823001_1 - 4.7e-06 25.9 0.6 7.9e-06 25.2 0.6 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.4 001244162.1_49823001_1 - 0.073 14.0 0.0 0.19 12.6 0.0 1.7 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Cys_knot PF00007.20 001285256.1_29524001_2 - 9.4e-06 25.7 11.1 2.1e-05 24.6 11.1 1.6 1 0 0 1 1 1 1 Cystine-knot domain DAN PF03045.13 001285256.1_29524001_2 - 0.00013 21.8 9.5 0.00025 20.9 9.5 1.4 1 0 0 1 1 1 1 DAN domain DUF4636 PF15468.4 001283184.1_29523001_1 - 1.7e-144 479.7 8.0 1.7e-144 479.7 8.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4636) AP3D1 PF06375.9 001283184.1_29523001_2 - 0.1 12.7 14.0 0.15 12.2 14.0 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 OAD_gamma PF04277.11 001283184.1_29523001_2 - 0.7 10.4 5.0 1.3 9.6 5.0 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Peptidase_S49_N PF08496.8 001283184.1_29523001_2 - 2.8 7.9 12.1 4.3 7.3 12.1 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Ferritin PF00210.22 001244131.1_49822001_3 - 1.6e-28 99.3 1.2 2.1e-28 98.9 1.2 1.2 1 0 0 1 1 1 1 Ferritin-like domain ANAPC4 PF12896.5 001244131.1_49822001_3 - 0.0061 15.9 0.0 0.0094 15.3 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 Glyco_hydro_35 PF01301.17 001284549.1_29526001_1 - 1.2e-118 396.2 0.0 1.6e-118 395.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.13 001284549.1_29526001_1 - 3.1e-11 43.1 0.2 8.2e-10 38.4 0.1 2.5 2 1 0 2 2 2 1 Beta-galactosidase BetaGal_dom4_5 PF13364.4 001284549.1_29526001_1 - 0.0072 16.8 0.2 0.04 14.4 0.1 2.2 2 0 0 2 2 2 1 Beta-galactosidase jelly roll domain DUF4647 PF15504.4 001319373.1_29525001_1 - 2.6e-224 745.3 19.2 3.3e-224 745.0 19.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4647) zf-CCCH_2 PF14608.4 001326309.1_26228001_3 - 4.1e-16 58.7 58.3 9e-05 22.7 6.2 6.4 5 0 0 5 5 5 5 RNA-binding, Nab2-type zinc finger Ribosomal_L2 PF00181.21 001316742.1_32922001_3 - 2.6e-29 100.9 0.1 1.1e-28 98.9 0.1 2.0 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain Ribosomal_L2_C PF03947.16 001316742.1_32922001_3 - 8.2e-29 100.2 0.3 2.8e-28 98.5 0.3 1.9 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Globin PF00042.20 001314043.1_37922001_2 - 2.3e-32 111.7 0.9 1.7e-31 108.9 0.0 2.1 2 0 0 2 2 2 1 Globin Globin PF00042.20 001082260.3_37922001_2 - 2.3e-32 111.7 0.9 1.7e-31 108.9 0.0 2.1 2 0 0 2 2 2 1 Globin Tubulin-binding PF00418.17 001322424.1_39727001_1 - 5.1e-60 199.0 27.9 7.7e-17 60.9 3.3 5.5 5 0 0 5 5 5 5 Tau and MAP protein, tubulin-binding repeat Tmemb_cc2 PF10267.7 001322424.1_39727001_1 - 0.17 10.9 2.3 0.93 8.4 0.3 2.1 1 1 1 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein Lectin_C PF00059.19 001009005.2_39722001_2 - 9.3e-19 68.0 0.1 1.6e-18 67.2 0.1 1.4 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.16 001009005.2_39722001_2 - 2.6e-08 33.4 30.5 8.8e-08 31.7 30.5 1.9 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) zf-H2C2_2 PF13465.4 001324157.1_26229001_1 - 1.2e-113 366.8 129.5 5.1e-09 36.0 0.3 20.1 20 0 0 20 20 19 18 Zinc-finger double domain zf-C2H2 PF00096.24 001324157.1_26229001_1 - 1.2e-96 311.9 119.3 2.4e-06 27.5 0.3 18.4 17 0 0 17 17 17 17 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001324157.1_26229001_1 - 1.5e-46 152.8 111.8 0.0058 17.2 0.3 18.4 17 0 0 17 17 17 17 C2H2-type zinc finger KRAB PF01352.25 001324157.1_26229001_1 - 3.7e-23 80.8 0.3 7.5e-23 79.8 0.3 1.6 1 0 0 1 1 1 1 KRAB box Zn-ribbon_8 PF09723.8 001324157.1_26229001_1 - 9.9e-20 70.3 75.3 0.00053 19.9 1.5 10.9 8 3 3 11 11 11 9 Zinc ribbon domain zf-C2H2_6 PF13912.4 001324157.1_26229001_1 - 4.3e-15 55.1 95.9 0.0011 18.7 0.6 17.2 17 0 0 17 17 17 9 C2H2-type zinc finger ADK_lid PF05191.12 001324157.1_26229001_1 - 1.9e-07 30.8 40.5 0.0024 17.7 0.3 9.0 7 2 0 7 7 7 5 Adenylate kinase, active site lid DUF3268 PF11672.6 001324157.1_26229001_1 - 0.00011 22.3 57.8 0.15 12.3 0.9 9.0 3 1 8 13 13 13 8 zinc-finger-containing domain DZR PF12773.5 001324157.1_26229001_1 - 0.00013 21.7 71.7 1.6e+04 -4.4 17.8 9.1 1 1 1 2 2 0 0 Double zinc ribbon C1_4 PF07975.10 001324157.1_26229001_1 - 0.0017 18.4 79.4 0.38 10.9 1.3 11.8 6 3 5 12 12 12 7 TFIIH C1-like domain zinc_ribbon_15 PF17032.3 001324157.1_26229001_1 - 0.0029 18.2 74.4 0.43 11.2 1.3 9.9 2 1 8 11 11 11 7 zinc-ribbon family zf-trcl PF13451.4 001324157.1_26229001_1 - 0.0062 16.3 71.8 2.4 8.0 0.2 14.9 15 2 0 15 15 15 3 Probable zinc-ribbon domain XPA_N PF01286.16 001324157.1_26229001_1 - 0.13 12.2 65.3 6.3 6.8 0.0 15.7 17 0 0 17 17 17 0 XPA protein N-terminal BolA PF01722.16 001324157.1_26229001_1 - 2 8.6 25.2 5 7.4 0.4 6.6 5 1 0 5 5 5 0 BolA-like protein zinc_ribbon_9 PF14369.4 001324157.1_26229001_1 - 3 8.1 38.9 1.4 9.1 0.0 12.8 16 0 0 16 16 15 0 zinc-ribbon Bromodomain PF00439.23 017934.6_26229001_3 - 1.2e-37 127.7 0.3 2.9e-18 65.6 0.0 2.6 2 0 0 2 2 2 2 Bromodomain WD40 PF00400.30 017934.6_26229001_3 - 1e-30 105.2 13.7 7.1e-05 23.4 0.1 8.7 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 017934.6_26229001_3 - 0.00047 20.3 0.5 0.043 14.0 0.2 3.4 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain E7 PF00527.16 017934.6_26229001_3 - 0.5 10.5 7.6 0.58 10.3 0.1 3.0 2 0 0 2 2 2 0 E7 protein, Early protein Lectin_C PF00059.19 001305933.1_29723001_1 - 1.1e-22 80.6 4.7 2.1e-22 79.8 4.7 1.5 1 0 0 1 1 1 1 Lectin C-type domain DUF2730 PF10805.6 001305933.1_29723001_1 - 5e-05 23.2 7.9 0.43 10.6 0.5 3.6 1 1 2 4 4 4 3 Protein of unknown function (DUF2730) Mhr1 PF12829.5 001305933.1_29723001_1 - 0.00019 21.3 8.3 24 4.9 0.0 6.5 1 1 6 7 7 7 0 Transcriptional regulation of mitochondrial recombination DUF2170 PF09938.7 001305933.1_29723001_1 - 0.00037 20.1 0.4 8.2 6.0 0.1 4.2 1 1 3 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2170) Med4 PF10018.7 001305933.1_29723001_1 - 0.0073 15.9 16.3 2.1 7.8 1.1 3.3 1 1 1 2 2 2 2 Vitamin-D-receptor interacting Mediator subunit 4 Med10 PF09748.7 001305933.1_29723001_1 - 0.0076 16.1 8.5 0.38 10.6 0.7 2.9 2 1 0 2 2 2 2 Transcription factor subunit Med10 of Mediator complex LINES_C PF14695.4 001305933.1_29723001_1 - 0.0081 15.5 0.2 12 5.3 0.1 5.2 7 0 0 7 7 7 0 Lines C-terminus HCMV_UL139 PF12507.6 001305933.1_29723001_1 - 0.013 15.8 6.1 0.4 10.9 0.1 3.4 1 1 2 3 3 3 0 Human Cytomegalovirus UL139 protein DUF4795 PF16043.3 001305933.1_29723001_1 - 0.014 14.9 11.2 0.06 12.8 0.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) DGCR6 PF07324.9 001305933.1_29723001_1 - 0.014 14.9 16.1 0.41 10.1 2.9 3.5 1 1 2 3 3 3 0 DiGeorge syndrome critical region 6 (DGCR6) protein Occludin_ELL PF07303.11 001305933.1_29723001_1 - 0.019 15.5 13.7 0.31 11.6 4.4 3.2 1 1 3 4 4 4 0 Occludin homology domain DUF617 PF04759.11 001305933.1_29723001_1 - 0.022 14.7 0.1 3.5 7.5 0.0 2.8 1 1 2 3 3 3 0 Protein of unknown function, DUF617 DUF3422 PF11902.6 001305933.1_29723001_1 - 0.037 13.0 10.7 2.6 6.9 0.3 3.5 1 1 3 4 4 4 0 Protein of unknown function (DUF3422) DIMCO_N PF16844.3 001305933.1_29723001_1 - 0.097 12.9 7.1 0.65 10.2 0.5 3.2 1 1 2 3 3 3 0 Dinitrogenase iron-molybdenum cofactor, N-terminal RRM_7 PF16367.3 001305933.1_29723001_1 - 0.11 12.5 0.1 1.9 8.5 0.1 2.5 1 1 1 2 2 2 0 RNA recognition motif DUF4665 PF15679.3 001305933.1_29723001_1 - 0.12 12.8 5.8 5.6 7.5 0.7 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4665) XhlA PF10779.7 001305933.1_29723001_1 - 0.14 12.3 0.3 5 7.3 0.0 3.2 2 1 2 4 4 4 0 Haemolysin XhlA IL22 PF14565.4 001305933.1_29723001_1 - 0.22 11.6 1.4 10 6.2 0.1 2.7 1 1 0 2 2 2 0 Interleukin 22 IL-10-related T-cell-derived-inducible factor RP-C_C PF11800.6 001305933.1_29723001_1 - 0.26 11.2 6.9 0.2 11.6 3.3 2.6 1 1 1 2 2 2 0 Replication protein C C-terminal region DUF2408 PF10303.7 001305933.1_29723001_1 - 0.5 10.8 17.5 5.2e+02 1.0 17.4 4.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) BLOC1_2 PF10046.7 001305933.1_29723001_1 - 0.65 10.2 17.6 2.3 8.5 0.6 4.5 2 1 2 4 4 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF241 PF03087.12 001305933.1_29723001_1 - 0.73 9.5 6.6 4.5 6.9 2.2 2.2 1 1 1 2 2 2 0 Arabidopsis protein of unknown function DUF972 PF06156.11 001305933.1_29723001_1 - 1.2 9.7 12.2 25 5.4 4.6 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF972) DUF489 PF04356.10 001305933.1_29723001_1 - 1.9 8.3 7.9 1.6 8.5 1.0 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF489) K-box PF01486.15 001305933.1_29723001_1 - 2.5 8.2 19.1 7.5 6.7 1.5 5.3 1 1 6 7 7 7 0 K-box region Mo25 PF08569.9 001305933.1_29723001_1 - 2.7 7.2 11.3 1.9 7.7 1.1 2.4 1 1 0 2 2 2 0 Mo25-like Snapin_Pallidin PF14712.4 001305933.1_29723001_1 - 3 8.2 20.9 7.9 6.9 1.6 3.8 1 1 3 4 4 4 0 Snapin/Pallidin tRNA-synt_His PF13393.4 001305933.1_29723001_1 - 3.8 6.5 7.8 12 4.9 1.5 2.5 1 1 3 4 4 4 0 Histidyl-tRNA synthetase Med15_fungi PF05397.10 001305933.1_29723001_1 - 8.3 6.6 10.0 21 5.3 2.5 3.6 1 1 2 3 3 3 0 Mediator complex subunit 15 YkuI_C PF10388.7 001305933.1_29723001_1 - 9 5.9 12.0 23 4.6 0.4 3.3 1 1 2 3 3 3 0 EAL-domain associated signalling protein domain HSP70 PF00012.18 001314303.1_09024001_1 - 1.5e-260 865.4 8.6 1.7e-260 865.2 8.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.11 001314303.1_09024001_1 - 3.8e-16 58.7 0.2 2e-15 56.3 0.1 1.9 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.14 001314303.1_09024001_1 - 0.00061 19.4 0.0 0.0019 17.8 0.0 1.8 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.4 001314303.1_09024001_1 - 0.0019 18.5 3.8 1.4 9.3 0.0 3.6 3 2 0 3 3 3 2 Cell division protein FtsA Zinicin_2 PF10103.7 001314303.1_09024001_1 - 0.051 12.7 0.0 0.082 12.0 0.0 1.3 1 0 0 1 1 1 0 Zinicin-like metallopeptidase DDR PF08841.8 001314303.1_09024001_1 - 0.064 12.1 0.1 0.44 9.3 0.0 2.0 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain CRIC_ras_sig PF10534.7 001314303.1_09024001_1 - 0.11 12.6 0.1 0.41 10.7 0.0 2.0 2 0 0 2 2 2 0 Connector enhancer of kinase suppressor of ras 7tm_1 PF00001.19 001322264.1_37923001_3 - 1.2e-38 132.8 15.2 1.5e-38 132.5 15.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.7 001322264.1_37923001_3 - 1e-05 24.9 5.0 1e-05 24.9 5.0 1.8 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srt PF10321.7 001322264.1_37923001_3 - 0.00051 19.0 20.8 0.19 10.5 21.1 2.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srt 7TM_GPCR_Srv PF10323.7 001322264.1_37923001_3 - 0.00094 18.5 11.0 0.0015 17.8 10.8 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.7 001322264.1_37923001_3 - 0.0028 17.0 10.1 0.33 10.1 5.0 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 001322264.1_37923001_3 - 0.21 11.2 10.6 3.2 7.3 10.6 2.0 1 1 0 1 1 1 0 Olfactory receptor ECSCR PF15820.3 001322264.1_37923001_3 - 0.68 9.7 2.7 1.1 9.0 0.2 2.2 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator Asp PF00026.21 001009122.2_39723001_1 - 2.5e-114 381.8 0.8 3e-114 381.5 0.8 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.4 001009122.2_39723001_1 - 8.4e-12 45.6 1.2 2.4e-09 37.6 1.2 2.7 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.4 001009122.2_39723001_1 - 2.3e-07 30.6 0.0 1.9e-06 27.6 0.0 2.3 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal A1_Propeptide PF07966.10 001009122.2_39723001_1 - 5.5e-05 22.8 0.7 9.7e-05 22.0 0.7 1.3 1 0 0 1 1 1 1 A1 Propeptide Asp_protease_2 PF13650.4 001009122.2_39723001_1 - 0.00021 21.8 0.1 0.85 10.2 0.0 2.9 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.4 001009122.2_39723001_1 - 0.0076 16.6 0.0 5 7.6 0.0 2.7 2 1 0 2 2 2 2 gag-polyprotein putative aspartyl protease Peptidase_C71 PF12386.6 001009122.2_39723001_1 - 0.045 13.3 0.0 0.54 9.8 0.0 2.2 2 0 0 2 2 2 0 Pseudomurein endo-isopeptidase Pei Globin PF00042.20 001304885.1_01322001_3 - 2e-31 108.7 0.2 2.7e-30 105.0 0.0 2.0 2 0 0 2 2 2 1 Globin BCA_ABC_TP_C PF12399.6 001304885.1_01322001_3 - 0.007 16.1 1.4 0.093 12.5 0.0 2.3 2 0 0 2 2 2 1 Branched-chain amino acid ATP-binding cassette transporter TPR_1 PF00515.26 001009083.2_39724001_2 - 3.6e-14 51.8 6.8 7e-05 22.3 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.15 001009083.2_39724001_2 - 5e-11 41.7 5.3 0.0085 16.0 0.0 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat CS PF04969.14 001009083.2_39724001_2 - 1.3e-09 38.8 0.0 3.8e-09 37.3 0.0 1.8 1 0 0 1 1 1 1 CS domain TPR_11 PF13414.4 001009083.2_39724001_2 - 5.3e-08 32.3 3.9 0.00014 21.4 1.3 2.7 2 1 0 2 2 2 2 TPR repeat TPR_9 PF13371.4 001009083.2_39724001_2 - 2.8e-06 27.3 0.1 0.0063 16.5 0.1 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.4 001009083.2_39724001_2 - 0.00084 19.2 13.9 0.27 11.4 0.6 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.4 001009083.2_39724001_2 - 0.0024 18.4 0.3 0.6 10.7 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.4 001009083.2_39724001_2 - 0.0029 17.7 7.3 0.097 12.8 0.1 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat Glyco_transf_41 PF13844.4 001009083.2_39724001_2 - 0.55 8.5 4.6 0.85 7.9 4.6 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 41 TPR_19 PF14559.4 001009083.2_39724001_2 - 7.7 7.0 9.9 0.25 11.8 0.8 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Cadherin PF00028.15 001082565.2_39729001_3 - 2.8e-83 274.4 0.0 1.7e-19 69.9 0.1 6.2 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001082565.2_39729001_3 - 2.2e-33 113.8 0.0 2.8e-28 97.4 0.0 5.0 5 0 0 5 5 5 2 Cadherin-like Cadherin_tail PF15974.3 001082565.2_39729001_3 - 2e-25 89.5 3.3 4e-25 88.6 3.3 1.5 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_C_2 PF16492.3 001082565.2_39729001_3 - 1.1e-22 80.5 0.2 3.6e-22 78.8 0.1 2.0 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.3 001082565.2_39729001_3 - 2.2e-08 33.9 3.5 0.8 9.6 0.1 5.1 5 0 0 5 5 5 3 Cadherin-like Keratin_2_tail PF16210.3 001319455.1_29525001_2 - 7.1 6.7 15.8 16 5.6 15.8 1.5 1 0 0 1 1 1 0 Keratin type II cytoskeletal 1 tail EPTP PF03736.15 001319455.1_29525001_3 - 9.4e-73 239.9 4.5 1.8e-11 43.7 0.0 7.3 7 0 0 7 7 7 7 EPTP domain LRR_8 PF13855.4 001319455.1_29525001_3 - 1e-20 73.1 18.2 1.1e-12 47.3 6.7 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_5 PF13306.4 001319455.1_29525001_3 - 5.4e-07 29.5 0.1 8.5e-07 28.9 0.1 1.2 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_9 PF14580.4 001319455.1_29525001_3 - 0.00044 19.7 0.3 0.00071 19.0 0.3 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.5 001319455.1_29525001_3 - 0.00045 20.4 14.8 0.015 15.6 2.3 2.6 1 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRRCT PF01463.22 001319455.1_29525001_3 - 0.0019 18.5 0.5 0.017 15.5 0.6 2.7 2 0 0 2 2 2 1 Leucine rich repeat C-terminal domain PFU PF09070.9 001319455.1_29525001_3 - 0.11 12.6 0.1 0.37 11.0 0.0 1.9 2 0 0 2 2 2 0 PFU (PLAA family ubiquitin binding) TNF PF00229.16 001305919.1_29722001_2 - 3e-29 101.4 0.1 5.4e-29 100.6 0.1 1.4 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family ATE_C PF04377.13 001319366.1_29525001_3 - 1.8e-51 174.2 1.3 3e-51 173.4 1.3 1.4 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.11 001319366.1_29525001_3 - 2.3e-31 107.9 6.2 5.3e-31 106.7 6.2 1.7 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus Pkinase PF00069.23 001319445.1_29525001_3 - 9.5e-50 169.3 0.0 1.7e-49 168.4 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001319445.1_29525001_3 - 3.7e-25 88.6 0.0 5.3e-25 88.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 001319445.1_29525001_3 - 3.2e-05 23.8 0.2 0.00013 21.8 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.4 001319445.1_29525001_3 - 0.022 13.9 0.1 0.049 12.8 0.1 1.5 1 1 0 1 1 1 0 Kinase-like Kdo PF06293.12 001319445.1_29525001_3 - 0.029 13.6 0.0 0.057 12.6 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.9 001319445.1_29525001_3 - 0.038 12.8 0.0 0.057 12.2 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase zf-CCCH_2 PF14608.4 001326299.1_26229001_1 - 9.2e-16 57.5 58.3 0.0001 22.5 6.2 6.3 5 0 0 5 5 5 5 RNA-binding, Nab2-type zinc finger PWI PF01480.15 001326299.1_26229001_1 - 0.056 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 PWI domain Cadherin PF00028.15 001082567.2_39729001_2 - 2.4e-82 271.4 0.0 7.8e-17 61.4 0.0 6.2 5 1 1 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001082567.2_39729001_2 - 3.8e-33 113.0 0.1 1.7e-29 101.4 0.0 4.3 6 0 0 6 6 6 2 Cadherin-like Cadherin_C_2 PF16492.3 001082567.2_39729001_2 - 1e-25 90.2 0.1 2.1e-25 89.2 0.1 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_tail PF15974.3 001082567.2_39729001_2 - 2e-25 89.6 3.3 4e-25 88.5 3.3 1.5 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_3 PF16184.3 001082567.2_39729001_2 - 5.1e-05 23.1 1.0 1.8 8.4 0.0 4.5 4 0 0 4 4 4 1 Cadherin-like TMEM154 PF15102.4 001082567.2_39729001_2 - 0.073 12.8 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 TMEM154 protein family ChitinaseA_N PF08329.8 001082567.2_39729001_2 - 0.098 12.2 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Chitinase A, N-terminal domain TSGA13 PF14994.4 001319628.1_29523001_1 - 5.6e-125 416.0 12.0 5.6e-125 416.0 12.0 1.5 2 0 0 2 2 2 1 Testis-specific gene 13 protein SR-25 PF10500.7 001319628.1_29523001_3 - 0.043 13.3 15.4 0.061 12.8 15.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AP3D1 PF06375.9 001319628.1_29523001_3 - 5.8 7.0 16.6 9.6 6.3 16.6 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 LETM1 PF07766.11 001351330.1_26224001_2 - 2e-44 151.8 0.1 2.6e-44 151.4 0.1 1.1 1 0 0 1 1 1 1 LETM1-like protein ATP-synt_ab PF00006.23 001195525.1_21024001_3 - 2.1e-64 217.0 0.0 2.8e-64 216.5 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.21 001195525.1_21024001_3 - 6.3e-22 77.8 2.4 1.2e-21 76.9 2.4 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATPase_2 PF01637.16 001195525.1_21024001_3 - 0.0091 15.8 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea DUF258 PF03193.14 001195525.1_21024001_3 - 0.03 14.1 0.0 0.062 13.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ATPase PF06745.11 001195525.1_21024001_3 - 0.042 13.1 0.1 0.068 12.4 0.1 1.3 1 0 0 1 1 1 0 KaiC AAA PF00004.27 001195525.1_21024001_3 - 0.071 13.4 0.0 1.4 9.3 0.0 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.20 001195525.1_21024001_3 - 0.1 11.5 1.0 0.12 11.3 0.1 1.5 2 0 0 2 2 2 0 NB-ARC domain AAA_19 PF13245.4 001195525.1_21024001_3 - 0.13 12.4 0.7 0.33 11.1 0.2 1.8 2 0 0 2 2 2 0 AAA domain NACHT PF05729.10 001195525.1_21024001_3 - 0.15 11.9 0.0 0.75 9.6 0.0 2.1 2 0 0 2 2 2 0 NACHT domain AAA_16 PF13191.4 001195525.1_21024001_3 - 0.15 12.3 0.4 0.57 10.4 0.0 2.1 2 1 0 2 2 2 0 AAA ATPase domain DUF2075 PF09848.7 001195525.1_21024001_3 - 0.26 10.3 0.1 0.63 9.1 0.1 1.5 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2075) ATP-synt_F6 PF05511.9 001131933.1_43522001_2 - 2.7e-41 139.8 0.3 2.7e-41 139.8 0.3 1.8 2 0 0 2 2 2 1 Mitochondrial ATP synthase coupling factor 6 DUF4604 PF15377.4 001131933.1_43522001_2 - 0.00094 19.5 7.9 0.0011 19.4 7.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) OAD_gamma PF04277.11 001131933.1_43522001_2 - 7.8 7.0 9.8 13 6.3 9.8 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Ribosomal_L26 PF16906.3 001304872.1_01321001_1 - 9.7e-43 144.5 5.6 1.3e-42 144.0 5.6 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.27 001304872.1_01321001_1 - 7.8e-08 31.9 5.7 2.4e-07 30.4 5.7 2.0 1 1 0 1 1 1 1 KOW motif Sedlin_N PF04628.11 001271112.1_45722001_3 - 4.1e-49 165.9 1.8 6.4e-49 165.3 0.2 1.8 2 0 0 2 2 2 1 Sedlin, N-terminal conserved region Sybindin PF04099.10 001271112.1_45722001_3 - 2.6e-08 33.7 0.1 4.6e-08 32.9 0.1 1.3 1 0 0 1 1 1 1 Sybindin-like family NPBW PF15180.4 153294.1_45722001_1 - 1.2e-30 105.6 0.2 1.6e-30 105.1 0.2 1.2 1 0 0 1 1 1 1 Neuropeptides B and W Cadherin PF00028.15 001082554.2_39729001_1 - 6.8e-80 263.5 0.0 2.3e-17 63.1 0.0 6.2 5 1 1 6 6 6 6 Cadherin domain Cadherin_2 PF08266.10 001082554.2_39729001_1 - 4.3e-26 90.4 0.0 4.5e-24 83.9 0.0 3.6 4 0 0 4 4 4 1 Cadherin-like Cadherin_tail PF15974.3 001082554.2_39729001_1 - 2e-25 89.5 3.3 4e-25 88.5 3.3 1.5 1 0 0 1 1 1 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_3 PF16184.3 001082554.2_39729001_1 - 1.7e-05 24.7 0.0 4 7.4 0.0 4.6 4 1 0 4 4 4 2 Cadherin-like Cadherin_C_2 PF16492.3 001082554.2_39729001_1 - 0.006 17.2 0.3 0.016 15.9 0.3 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Mt_ATP-synt_D PF05873.10 001351580.1_26229001_1 - 0.00082 19.1 6.6 0.00082 19.1 6.6 5.1 4 4 3 8 8 8 1 ATP synthase D chain, mitochondrial (ATP5H) NAT PF04768.11 001351580.1_26229001_1 - 0.0036 16.9 2.9 0.14 11.7 0.1 3.0 2 0 0 2 2 2 2 NAT, N-acetyltransferase, of N-acetylglutamate synthase Invasin_D3 PF09134.8 001351580.1_26229001_1 - 0.081 12.5 0.0 0.42 10.3 0.0 2.1 2 0 0 2 2 2 0 Invasin, domain 3 RGS PF00615.17 019341.1_45722001_1 - 4.1e-35 120.5 4.7 5.1e-35 120.2 4.7 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain Gag_p19 PF02228.14 019341.1_45722001_1 - 0.07 13.4 0.0 2.7 8.3 0.0 2.2 1 1 1 2 2 2 0 Major core protein p19 PKK PF12474.6 001173020.2_09929001_2 - 3.3e-75 250.6 97.7 1.2e-39 135.4 42.7 5.2 4 1 1 5 5 5 2 Polo kinase kinase Pkinase PF00069.23 001173020.2_09929001_2 - 2.1e-68 230.4 0.0 2.1e-68 230.4 0.0 2.8 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.15 001173020.2_09929001_2 - 9e-49 166.0 0.0 9e-49 166.0 0.0 2.3 3 0 0 3 3 3 1 Protein tyrosine kinase Pro_isomerase PF00160.19 001143883.3_26222001_1 - 4.5e-40 137.4 0.2 5.4e-40 137.1 0.2 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD HLH PF00010.24 001285755.1_09028001_1 - 6.8e-17 61.0 0.6 1.5e-16 59.9 0.6 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PRKG1_interact PF15898.3 001285755.1_09028001_1 - 0.078 13.8 0.2 0.15 12.9 0.2 1.4 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain GIT_CC PF16559.3 001285755.1_09028001_1 - 0.12 12.3 0.7 0.26 11.2 0.7 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor UQ_con PF00179.24 001356595.1_32928001_3 - 2.8e-51 172.7 0.0 3.9e-51 172.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Lipocalin PF00061.21 001039746.2_49822001_2 - 2.1e-16 60.3 3.4 2.5e-16 60.0 3.4 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 001039746.2_49822001_2 - 0.00019 21.2 1.2 0.00025 20.9 1.2 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family MHC_I PF00129.16 001318354.1_29623001_1 - 4.3e-92 306.4 2.6 6e-92 306.0 2.6 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001318354.1_29623001_1 - 4.5e-17 62.2 0.0 9.3e-17 61.2 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001318354.1_29623001_1 - 1.8e-13 50.0 10.8 3.3e-13 49.2 10.8 1.5 1 0 0 1 1 1 1 MHC_I C-terminus Ig_3 PF13927.4 001318354.1_29623001_1 - 4.8e-06 27.0 0.8 0.02 15.4 0.0 2.9 1 1 1 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.10 001318354.1_29623001_1 - 0.0027 17.6 1.5 0.0034 17.3 0.1 1.8 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain ig PF00047.23 001318354.1_29623001_1 - 0.008 16.2 0.1 0.027 14.5 0.1 1.9 2 0 0 2 2 2 1 Immunoglobulin domain PNMA PF14893.4 001358439.1_32929001_2 - 1.5e-37 129.6 0.1 2.1e-37 129.1 0.1 1.1 1 0 0 1 1 1 1 PNMA VMA21 PF09446.8 001358439.1_32929001_3 - 8.9e-06 25.6 1.8 1.9e-05 24.5 1.8 1.5 1 0 0 1 1 1 1 VMA21-like domain IRK PF01007.18 073406.1_32929120_2 - 1.5e-135 451.2 2.7 2.1e-135 450.8 2.7 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.14 073406.1_32929120_2 - 0.019 14.8 3.8 0.051 13.4 3.8 1.7 1 0 0 1 1 1 0 Ion channel DUF2182 PF09948.7 073406.1_32929120_2 - 0.075 12.8 0.4 0.19 11.5 0.4 1.6 1 0 0 1 1 1 0 Predicted metal-binding integral membrane protein (DUF2182) HD-ZIP_N PF04618.10 073406.1_32929120_3 - 1.6 9.1 9.5 6.7 7.1 0.1 3.5 3 0 0 3 3 3 0 HD-ZIP protein N terminus fn3 PF00041.19 073118.1_26226120_1 - 0.0008 19.6 0.0 0.0015 18.7 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain YoaP PF14268.4 073118.1_26226120_1 - 0.088 12.2 0.8 2.3 7.7 0.0 2.9 3 0 0 3 3 3 0 YoaP-like Gtr1_RagA PF04670.10 148684.1_26225120_1 - 8.4e-98 326.2 4.1 1.4e-75 253.5 0.3 2.2 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.11 148684.1_26225120_1 - 4.9e-06 26.7 0.6 0.0019 18.3 0.5 2.6 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.20 148684.1_26225120_1 - 5.9e-06 25.8 0.9 0.00035 20.1 0.2 2.3 1 1 1 2 2 2 2 Ras family Arf PF00025.19 148684.1_26225120_1 - 1.7e-05 24.2 0.4 0.00013 21.4 0.4 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 148684.1_26225120_1 - 0.0014 18.6 0.0 0.0045 16.9 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.25 148684.1_26225120_1 - 0.095 13.1 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 ABC transporter PduV-EutP PF10662.7 148684.1_26225120_1 - 0.1 12.2 0.1 0.24 11.0 0.1 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation G-alpha PF00503.18 148684.1_26225120_1 - 3.3 6.6 6.8 6.7 5.6 0.5 2.4 2 1 0 3 3 3 0 G-protein alpha subunit Gtr1_RagA PF04670.10 148686.1_26225120_1 - 1.8e-96 321.9 0.6 2.7e-96 321.3 0.6 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.20 148686.1_26225120_1 - 6.9e-06 25.6 0.9 0.00031 20.3 0.9 2.1 1 1 0 1 1 1 1 Ras family Roc PF08477.11 148686.1_26225120_1 - 7e-06 26.1 0.5 0.0019 18.3 0.5 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 148686.1_26225120_1 - 2.3e-05 23.8 0.5 0.00013 21.3 0.5 1.9 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 148686.1_26225120_1 - 0.0017 18.3 0.0 0.0046 16.9 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.7 148686.1_26225120_1 - 0.11 12.2 0.1 0.25 11.0 0.1 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.25 148686.1_26225120_1 - 0.11 12.9 0.0 0.18 12.2 0.0 1.3 1 0 0 1 1 1 0 ABC transporter G-alpha PF00503.18 148686.1_26225120_1 - 0.36 9.8 3.1 6.9 5.6 0.5 2.2 1 1 0 2 2 2 0 G-protein alpha subunit TIR PF01582.18 152416.1_32929120_1 - 3e-27 95.4 0.0 4.8e-27 94.7 0.0 1.3 1 0 0 1 1 1 1 TIR domain Ig_3 PF13927.4 152416.1_32929120_1 - 1.2e-15 57.7 2.3 1.3e-08 35.2 0.4 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.4 152416.1_32929120_1 - 2e-12 47.1 1.9 2e-06 27.9 0.1 3.5 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.14 152416.1_32929120_1 - 1.5e-09 37.6 0.1 0.016 15.1 0.1 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.23 152416.1_32929120_1 - 3.1e-08 33.5 2.0 0.0034 17.4 0.1 3.6 3 0 0 3 3 3 2 Immunoglobulin domain TIR_2 PF13676.4 152416.1_32929120_1 - 0.00074 19.7 0.0 0.0014 18.8 0.0 1.4 1 0 0 1 1 1 1 TIR domain HTH_IclR PF09339.8 133640.1_26223120_3 - 0.14 11.8 0.1 0.33 10.6 0.1 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain F-box-like PF12937.5 152421.1_26225120_3 - 5.9e-07 29.1 2.1 1.5e-06 27.8 1.0 2.4 2 0 0 2 2 2 1 F-box-like F-box PF00646.31 152421.1_26225120_3 - 0.023 14.5 3.5 0.045 13.5 1.0 2.8 3 0 0 3 3 3 0 F-box domain Glyco_transf_7N PF13733.4 152434.1_32925120_1 - 1.1e-59 199.7 0.1 2.1e-59 198.9 0.1 1.5 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.12 152434.1_32925120_1 - 5.2e-05 22.7 0.0 0.00013 21.5 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase PI-PLC-X PF00388.17 014996.3_26229001_2 - 8.5e-64 213.4 0.0 2.1e-63 212.1 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.17 014996.3_26229001_2 - 9.1e-39 132.3 0.5 9.1e-39 132.3 0.5 2.2 2 0 0 2 2 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.9 014996.3_26229001_2 - 1.6e-17 63.7 0.2 5.4e-17 61.9 0.2 2.0 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.28 014996.3_26229001_2 - 5.6e-16 58.6 0.0 1.8e-15 57.0 0.0 1.9 1 0 0 1 1 1 1 C2 domain EF-hand_7 PF13499.4 014996.3_26229001_2 - 6.3e-11 42.5 2.7 1.7e-10 41.1 0.4 2.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.30 014996.3_26229001_2 - 8.4e-10 37.4 1.7 5.9e-05 22.2 0.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.4 014996.3_26229001_2 - 3.8e-07 29.4 0.9 0.032 14.0 0.0 3.7 3 0 0 3 3 3 2 EF-hand domain PH_12 PF16457.3 014996.3_26229001_2 - 3.5e-06 27.4 0.0 1.2e-05 25.7 0.0 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain EF-hand_10 PF14788.4 014996.3_26229001_2 - 8.5e-06 25.4 2.2 2.4e-05 24.0 0.1 2.7 2 1 1 3 3 2 2 EF hand EF-hand_5 PF13202.4 014996.3_26229001_2 - 2.3e-05 23.6 0.3 0.0019 17.5 0.1 2.8 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.4 014996.3_26229001_2 - 3.2e-05 23.5 0.3 0.015 15.0 0.1 2.7 1 1 1 2 2 2 2 EF-hand domain pair PH PF00169.27 014996.3_26229001_2 - 0.0051 17.2 0.0 0.014 15.7 0.0 1.8 1 0 0 1 1 1 1 PH domain EF-hand_4 PF12763.5 014996.3_26229001_2 - 0.013 15.3 0.1 0.044 13.6 0.1 1.9 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.7 014996.3_26229001_2 - 0.015 15.4 0.1 0.044 14.0 0.1 1.7 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Pkinase PF00069.23 001177974.1_32926001_3 - 5e-39 134.1 0.0 7.5e-39 133.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001177974.1_32926001_3 - 2.4e-36 125.2 0.0 2.4e-35 121.9 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Death PF00531.20 001177974.1_32926001_3 - 9.2e-11 41.6 1.2 1.6e-10 40.9 1.2 1.4 1 0 0 1 1 1 1 Death domain RAMP PF04901.11 001177974.1_32926001_3 - 0.006 16.4 0.1 0.012 15.4 0.1 1.4 1 0 0 1 1 1 1 Receptor activity modifying family APH PF01636.21 001177974.1_32926001_3 - 0.012 15.4 0.9 0.025 14.4 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.9 001177974.1_32926001_3 - 0.25 10.2 0.0 0.53 9.2 0.0 1.4 2 0 0 2 2 2 0 Seadornavirus VP7 Vps8 PF12816.5 001009921.2_26229001_1 - 2.1e-59 200.2 7.2 4.3e-58 195.9 0.8 2.7 2 0 0 2 2 2 2 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.18 001009921.2_26229001_1 - 1.6e-06 28.0 12.3 0.00014 21.6 0.5 4.1 4 0 0 4 4 4 3 Region in Clathrin and VPS zf-RING_11 PF17123.3 001009921.2_26229001_1 - 1.5e-05 24.4 2.7 5.6e-05 22.6 2.7 2.0 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.4 001009921.2_26229001_1 - 0.0063 16.4 6.5 0.0063 16.4 6.5 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.4 001009921.2_26229001_1 - 0.0081 16.0 8.0 0.023 14.5 8.0 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3H2C3 PF17122.3 001009921.2_26229001_1 - 0.0088 15.9 1.6 0.028 14.3 1.6 1.9 1 0 0 1 1 1 1 Zinc-finger zf-RING_2 PF13639.4 001009921.2_26229001_1 - 0.01 16.0 6.6 0.041 14.0 6.6 2.2 1 0 0 1 1 1 0 Ring finger domain PHD PF00628.27 001009921.2_26229001_1 - 0.015 15.0 8.3 0.041 13.6 8.3 1.8 1 0 0 1 1 1 0 PHD-finger zf-C3HC4 PF00097.23 001009921.2_26229001_1 - 0.18 11.5 7.6 0.58 9.9 7.6 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) GED PF02212.16 001009921.2_26229001_1 - 0.27 11.3 3.5 0.35 10.9 0.2 2.6 2 0 0 2 2 2 0 Dynamin GTPase effector domain zf-C3HC4_2 PF13923.4 001009921.2_26229001_1 - 0.98 9.2 3.8 4 7.2 3.8 2.1 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Amelogenin PF02948.13 213800.1_49822001_2 - 2e-64 217.3 44.8 2.7e-64 216.9 44.8 1.1 1 0 0 1 1 1 1 Amelogenin TFIIA PF03153.11 213800.1_49822001_2 - 3.9 7.2 7.2 4.4 7.1 7.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ATP-synt_ab PF00006.23 001135736.1_39724001_2 - 1.1e-74 250.6 0.0 1.6e-74 250.0 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.25 001135736.1_39724001_2 - 2.5e-47 160.2 1.4 3.9e-47 159.5 1.4 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.21 001135736.1_39724001_2 - 1e-16 61.0 1.2 2.5e-16 59.8 1.2 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF4142 PF13628.4 001135736.1_39724001_2 - 0.00014 21.9 1.1 0.00028 21.0 1.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4142) Bromodomain PF00439.23 001100903.1_45729001_1 - 5.7e-43 144.7 1.6 1.7e-20 72.7 0.1 2.5 2 0 0 2 2 2 2 Bromodomain BET PF17035.3 001100903.1_45729001_1 - 2.7e-29 101.0 0.2 6.2e-29 99.8 0.2 1.7 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation BRD4_CDT PF17105.3 001100903.1_45729001_1 - 1.4e-24 85.3 9.1 1.4e-24 85.3 9.1 3.8 3 1 0 3 3 3 1 C-terminal domain of bromodomain protein 4 PI3K_P85_iSH2 PF16454.3 022185.2_45727001_3 - 9.2e-59 197.5 20.2 1.2e-58 197.1 20.2 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain SH2 PF00017.22 022185.2_45727001_3 - 5.6e-40 135.1 0.1 1e-19 70.2 0.0 2.4 2 0 0 2 2 2 2 SH2 domain RhoGAP PF00620.25 022185.2_45727001_3 - 1.9e-14 53.6 0.0 1.7e-13 50.5 0.0 2.4 2 1 0 2 2 2 1 RhoGAP domain SH3_9 PF14604.4 022185.2_45727001_3 - 0.0061 16.3 0.0 0.015 15.0 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.26 022185.2_45727001_3 - 0.062 12.8 0.3 0.64 9.5 0.0 2.8 3 0 0 3 3 3 0 SH3 domain Tai4 PF16695.3 022185.2_45727001_3 - 0.24 11.8 2.0 0.59 10.6 2.0 1.6 1 0 0 1 1 1 0 Type VI secretion system (T6SS), amidase immunity protein ATG11 PF10377.7 022185.2_45727001_3 - 0.73 9.8 4.8 0.1 12.5 0.5 1.7 2 0 0 2 2 2 0 Autophagy-related protein 11 Laminin_I PF06008.12 022185.2_45727001_3 - 0.91 9.0 13.0 1.7 8.1 13.0 1.4 1 0 0 1 1 1 0 Laminin Domain I Mod_r PF07200.11 022185.2_45727001_3 - 1.2 9.1 21.2 2.5 8.1 4.8 2.4 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF4407 PF14362.4 022185.2_45727001_3 - 7.8 5.6 8.1 12 5.0 8.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.13 022185.2_45727001_3 - 8.8 5.7 9.1 16 4.8 9.1 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DNA_ligase_A_M PF01068.19 001291247.1_32929001_2 - 5.5e-62 208.9 0.0 8.1e-62 208.4 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.12 001291247.1_32929001_2 - 1.1e-31 110.4 0.1 2.3e-31 109.3 0.1 1.5 1 0 0 1 1 1 1 DNA ligase N terminus LIG3_BRCT PF16759.3 001291247.1_32929001_2 - 1.4e-25 89.2 0.0 3e-25 88.2 0.0 1.6 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain zf-PARP PF00645.16 001291247.1_32929001_2 - 3.3e-23 82.2 2.3 7.4e-23 81.1 2.3 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region DNA_ligase_A_C PF04679.13 001291247.1_32929001_2 - 2.4e-18 66.4 0.0 4.6e-18 65.5 0.0 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT_2 PF16589.3 001291247.1_32929001_2 - 6.1e-07 29.6 0.0 1.4e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain RNA_ligase PF09414.8 001291247.1_32929001_2 - 0.00013 22.2 0.0 0.00023 21.4 0.0 1.3 1 0 0 1 1 1 1 RNA ligase mRNA_cap_enzyme PF01331.17 001291247.1_32929001_2 - 0.013 15.2 0.0 0.028 14.1 0.0 1.5 1 0 0 1 1 1 0 mRNA capping enzyme, catalytic domain zf-DHHC PF01529.18 001301257.1_21028001_3 - 9.2e-34 116.3 11.6 9.2e-34 116.3 11.6 2.5 2 0 0 2 2 2 1 DHHC palmitoyltransferase Pkinase_Tyr PF07714.15 001195670.1_37929001_1 - 8.4e-102 339.8 0.0 1.2e-101 339.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.4 001195670.1_37929001_1 - 6.8e-59 196.3 12.7 2.6e-16 59.9 0.0 6.7 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.14 001195670.1_37929001_1 - 2.2e-48 162.1 4.0 5.3e-16 58.3 0.0 7.2 6 1 0 6 6 6 6 Immunoglobulin I-set domain Pkinase PF00069.23 001195670.1_37929001_1 - 2.1e-41 141.9 0.0 1.1e-29 103.5 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ig_2 PF13895.4 001195670.1_37929001_1 - 2.4e-31 107.7 23.4 2.3e-11 43.7 0.0 8.3 7 2 0 7 7 7 5 Immunoglobulin domain ig PF00047.23 001195670.1_37929001_1 - 2.5e-25 88.3 19.8 9.8e-10 38.3 0.1 7.7 7 2 0 7 7 7 4 Immunoglobulin domain V-set PF07686.15 001195670.1_37929001_1 - 6.1e-17 61.6 13.2 0.0011 19.0 0.1 9.0 6 4 2 8 8 8 3 Immunoglobulin V-set domain Izumo-Ig PF16706.3 001195670.1_37929001_1 - 1.1e-09 38.0 2.2 1.7 8.6 0.0 6.6 6 0 0 6 6 6 2 Izumo-like Immunoglobulin domain C2-set_2 PF08205.10 001195670.1_37929001_1 - 2.1e-07 30.8 9.3 0.037 14.0 0.1 4.6 4 0 0 4 4 4 3 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.3 001195670.1_37929001_1 - 1.5e-06 28.4 4.7 1.6 9.1 0.2 6.7 6 2 0 6 6 6 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 001195670.1_37929001_1 - 0.0001 22.4 7.5 3.2 8.1 0.1 5.7 6 0 0 6 6 6 2 T-cell surface glycoprotein CD3 delta chain C1-set PF07654.13 001195670.1_37929001_1 - 0.00013 22.2 5.0 1.1 9.7 0.2 5.4 5 0 0 5 5 5 1 Immunoglobulin C1-set domain Adeno_E3_CR1 PF02440.13 001195670.1_37929001_1 - 0.0092 15.6 8.3 5.7 6.7 0.0 5.1 5 0 0 5 5 5 2 Adenovirus E3 region protein CR1 HSR PF03172.11 003113.3_26228001_1 - 5e-44 148.4 0.5 9.1e-44 147.5 0.5 1.4 1 0 0 1 1 1 1 HSR domain SAND PF01342.19 003113.3_26228001_1 - 6.2e-33 112.2 1.1 1.6e-32 110.9 1.1 1.8 1 0 0 1 1 1 1 SAND domain HMG_box PF00505.17 003113.3_26228001_1 - 2.9e-28 98.0 9.5 3.2e-22 78.6 0.7 3.0 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.8 003113.3_26228001_1 - 4.1e-26 91.2 7.1 1e-13 51.5 1.7 3.0 2 0 0 2 2 2 2 HMG-box domain HMG_box_5 PF14887.4 003113.3_26228001_1 - 2.2 8.2 13.6 2.7 7.9 3.6 2.7 2 0 0 2 2 2 0 HMG (high mobility group) box 5 An_peroxidase PF03098.13 213999.2_49829001_1 - 1.1e-135 453.2 0.0 1.3e-135 452.8 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase NAD_binding_6 PF08030.10 213999.2_49829001_1 - 2.8e-30 105.4 0.0 4.3e-30 104.8 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.17 213999.2_49829001_1 - 7.1e-21 74.5 15.7 1.5e-20 73.5 15.7 1.6 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.10 213999.2_49829001_1 - 2.6e-17 62.7 0.0 5.7e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain EF-hand_1 PF00036.30 213999.2_49829001_1 - 2.6e-11 42.1 10.6 5.3e-06 25.5 0.2 3.1 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.4 213999.2_49829001_1 - 5.9e-11 42.5 5.5 9.5e-06 25.9 2.2 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.4 213999.2_49829001_1 - 2e-09 36.9 9.4 2.6e-05 23.8 0.1 3.4 1 1 2 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.4 213999.2_49829001_1 - 6.2e-09 35.0 6.4 0.001 18.7 0.4 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.4 213999.2_49829001_1 - 1.6e-06 27.2 1.9 0.029 13.8 0.1 2.7 2 0 0 2 2 2 2 EF hand NAD_binding_1 PF00175.19 213999.2_49829001_1 - 0.0051 17.3 0.0 0.11 13.0 0.0 2.3 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Alpha_E2_glycop PF00943.17 213999.2_49829001_1 - 0.026 13.1 0.0 0.04 12.5 0.0 1.1 1 0 0 1 1 1 0 Alphavirus E2 glycoprotein PepSY_TM PF03929.14 213999.2_49829001_1 - 0.48 9.6 0.0 0.48 9.6 0.0 2.2 2 0 0 2 2 2 0 PepSY-associated TM region adh_short PF00106.23 172037.4_26228001_2 - 1.6e-39 135.3 0.0 1.2e-34 119.4 0.0 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.4 172037.4_26228001_2 - 9.1e-26 90.7 0.0 1.3e-22 80.4 0.0 2.2 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 172037.4_26228001_2 - 2.7e-05 24.0 0.0 5.3e-05 23.1 0.0 1.4 1 1 0 1 1 1 1 KR domain Ion_trans PF00520.29 053873.1_45729001_3 - 5.4e-258 850.9 83.0 8.6e-73 244.4 16.3 4.1 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.3 053873.1_45729001_3 - 2.2e-35 120.1 0.0 5.6e-35 118.8 0.0 1.7 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 053873.1_45729001_3 - 5.9e-29 100.0 0.1 1.4e-28 98.8 0.1 1.7 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 053873.1_45729001_3 - 4.1e-12 45.4 21.9 3e-10 39.2 6.8 9.6 6 4 3 9 9 9 3 Polycystin cation channel CAC1F_C PF16885.3 053873.1_45729001_3 - 9.7e-06 25.3 7.2 1.5e-05 24.7 0.4 2.6 1 1 1 2 2 2 1 Voltage-gated calcium channel subunit alpha, C-term COX16 PF14138.4 053873.1_45729001_3 - 0.21 12.0 1.5 7.6 7.0 0.1 3.4 3 0 0 3 3 3 0 Cytochrome c oxidase assembly protein COX16 DUF2670 PF10875.6 053873.1_45729001_3 - 0.83 9.6 3.5 2.9 7.9 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2670) FKBP_C PF00254.26 013102.3_45724001_2 - 4.7e-34 116.4 0.0 6.6e-34 116.0 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase HTH_Tnp_4 PF13613.4 008771.3_32925001_1 - 0.066 12.9 0.1 0.15 11.8 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease P2X_receptor PF00864.17 008771.3_32925001_3 - 2.6e-154 513.6 0.0 3.3e-154 513.2 0.0 1.1 1 0 0 1 1 1 1 ATP P2X receptor Pkinase PF00069.23 053842.2_45729001_2 - 2.1e-67 227.1 0.0 2.7e-67 226.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 053842.2_45729001_2 - 8.2e-34 116.9 0.0 1.3e-33 116.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.21 053842.2_45729001_2 - 0.0074 16.1 0.1 0.014 15.2 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family TACI-CRD2 PF09305.8 012452.2_26223001_2 - 6e-29 99.7 21.3 2.4e-23 81.7 8.8 2.7 2 0 0 2 2 2 2 TACI, cysteine-rich domain BCMA-Tall_bind PF09257.8 012452.2_26223001_2 - 0.00013 21.8 18.3 0.012 15.5 5.7 3.3 2 0 0 2 2 2 2 BCMA, TALL-1 binding BaffR-Tall_bind PF09256.8 012452.2_26223001_2 - 0.08 12.6 10.8 0.1 12.3 0.4 3.5 3 0 0 3 3 3 0 BAFF-R, TALL-1 binding MIP-T3 PF10243.7 012452.2_26223001_3 - 3.1 6.3 20.3 5.6 5.4 20.3 1.4 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Aldo_ket_red PF00248.19 001253909.1_26223001_1 - 3.2e-18 65.8 0.0 4.1e-18 65.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family RRM_1 PF00076.20 001330603.1_26229001_1 - 5.4e-42 141.3 0.1 3.1e-16 58.8 0.0 3.7 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001330603.1_26229001_1 - 3.8e-06 26.8 0.0 0.18 11.8 0.0 3.5 3 0 0 3 3 3 2 RNA recognition motif Nup35_RRM_2 PF14605.4 001330603.1_26229001_1 - 0.011 15.6 0.0 0.38 10.6 0.0 3.0 4 0 0 4 4 4 0 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.4 001330603.1_26229001_1 - 0.013 15.0 0.0 0.36 10.3 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TF_Otx PF03529.11 001330603.1_26229001_1 - 2.6 8.4 14.5 0.97 9.7 3.3 2.5 2 0 0 2 2 2 0 Otx1 transcription factor UDG PF03167.17 001243787.1_26226001_1 - 0.00018 21.4 0.1 0.00068 19.5 0.1 1.8 1 1 0 1 1 1 1 Uracil DNA glycosylase superfamily DUF4918 PF16265.3 001243787.1_26226001_1 - 0.00044 19.7 0.0 0.0048 16.3 0.0 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4918) 7tm_1 PF00001.19 000684.2_26226001_3 - 2.7e-79 266.0 0.8 2.7e-79 266.0 0.8 1.8 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 000684.2_26226001_3 - 2.8e-15 56.3 0.0 2.8e-15 56.3 0.0 1.8 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.4 000684.2_26226001_3 - 3.8e-06 26.7 5.9 4.6e-06 26.4 3.7 2.0 2 0 0 2 2 2 1 Olfactory receptor Defensin_propep PF00879.16 001171015.1_37921001_1 - 4.2e-23 81.3 3.5 4.8e-23 81.1 3.0 1.4 2 0 0 2 2 2 1 Defensin propeptide Defensin_1 PF00323.17 001171015.1_37921001_1 - 3.3e-10 40.2 14.3 4.3e-10 39.8 14.3 1.2 1 0 0 1 1 1 1 Mammalian defensin FAST_1 PF06743.13 014929.3_26229001_3 - 6.8e-21 73.8 2.0 6.8e-21 73.8 2.0 2.0 2 0 0 2 2 2 1 FAST kinase-like protein, subdomain 1 RAP PF08373.8 014929.3_26229001_3 - 2e-11 43.7 0.0 4.3e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 RAP domain FAST_2 PF08368.10 014929.3_26229001_3 - 3.1e-08 34.2 0.3 8.7e-08 32.7 0.1 2.0 2 0 0 2 2 2 1 FAST kinase-like protein, subdomain 2 Tetraspannin PF00335.18 130783.4_26229001_3 - 8.4e-44 149.8 12.3 1.1e-43 149.3 12.3 1.2 1 0 0 1 1 1 1 Tetraspanin family SUR7 PF06687.10 130783.4_26229001_3 - 4 6.9 11.7 0.9 9.0 4.9 2.3 2 0 0 2 2 2 0 SUR7/PalI family Hormone_3 PF00159.16 001034080.1_45722001_1 - 1.1e-19 70.1 2.3 1.1e-19 70.1 2.3 1.7 2 0 0 2 2 2 1 Pancreatic hormone peptide Trp_oprn_chp PF09534.8 001034080.1_45722001_1 - 0.047 13.3 0.4 0.058 13.0 0.4 1.2 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) 7tm_1 PF00001.19 001108967.1_45728001_3 - 8.1e-49 166.1 11.6 1.1e-48 165.7 11.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.7 001108967.1_45728001_3 - 4.7e-07 29.3 9.0 6.2e-07 28.9 8.3 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.4 001108967.1_45728001_3 - 1.3e-06 28.2 3.4 1.3e-06 28.2 3.4 1.9 2 0 0 2 2 2 1 Olfactory receptor Troponin PF00992.18 017144.2_45722001_3 - 7.6e-45 152.4 6.6 1.6e-44 151.4 6.6 1.5 1 0 0 1 1 1 1 Troponin Troponin-I_N PF11636.6 017144.2_45722001_3 - 9.4e-18 63.7 10.6 1.5e-17 63.0 10.6 1.3 1 0 0 1 1 1 1 Troponin I residues 1-32 Tup_N PF08581.8 017144.2_45722001_3 - 0.0014 18.7 0.1 0.0014 18.7 0.1 2.2 3 0 0 3 3 3 1 Tup N-terminal DUF919 PF06034.9 017144.2_45722001_3 - 0.045 13.4 0.1 0.045 13.4 0.1 2.9 3 1 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF919) DUF2746 PF10874.6 017144.2_45722001_3 - 5 7.4 5.5 1.4 9.2 0.2 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF2746) RRM_1 PF00076.20 001353748.1_26229001_1 - 5.2e-42 141.4 0.1 3e-16 58.8 0.0 3.7 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 001353748.1_26229001_1 - 3.7e-06 26.8 0.0 0.17 11.9 0.0 3.5 3 0 0 3 3 3 2 RNA recognition motif Nup35_RRM_2 PF14605.4 001353748.1_26229001_1 - 0.01 15.7 0.0 0.38 10.6 0.0 3.0 4 0 0 4 4 4 0 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.4 001353748.1_26229001_1 - 0.01 15.3 0.0 0.26 10.8 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TF_Otx PF03529.11 001353748.1_26229001_1 - 5.1 7.4 13.8 0.96 9.8 3.3 2.5 2 0 0 2 2 2 0 Otx1 transcription factor NTF2 PF02136.18 005796.2_26225001_2 - 1.7e-31 109.1 0.0 2.4e-31 108.6 0.0 1.2 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain ATP-synt_C PF00137.19 017311.1_45722001_3 - 2.3e-11 43.7 12.4 3.7e-11 43.1 12.4 1.3 1 0 0 1 1 1 1 ATP synthase subunit C ATP-synt_DE_N PF02823.14 139106.1_45722001_2 - 1.1e-15 57.1 0.1 1.6e-15 56.6 0.1 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain ATP-synt_C PF00137.19 133556.2_45722001_1 - 3.5e-11 43.1 12.4 6.4e-11 42.3 12.4 1.4 1 0 0 1 1 1 1 ATP synthase subunit C EOS1 PF12326.6 133556.2_45722001_1 - 0.021 14.6 0.0 0.021 14.6 0.0 1.2 1 0 0 1 1 1 0 N-glycosylation protein Pex24p PF06398.9 133556.2_45722001_1 - 0.031 13.1 1.1 0.04 12.8 1.1 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin NEMP PF10225.7 133556.2_45722001_1 - 0.048 13.3 0.2 0.11 12.1 0.2 1.5 1 0 0 1 1 1 0 NEMP family Folate_carrier PF01770.16 133556.2_45722001_1 - 0.066 11.8 0.2 0.072 11.7 0.2 1.2 1 0 0 1 1 1 0 Reduced folate carrier RNA_pol_Rpc4 PF05132.12 133556.2_45722001_1 - 0.23 11.8 11.2 0.3 11.4 11.2 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 MCM_bind PF09739.7 133556.2_45722001_1 - 0.54 8.5 11.9 0.69 8.2 11.9 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor NPR3 PF03666.11 133556.2_45722001_1 - 0.9 8.1 13.9 1.2 7.8 13.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 EOS1 PF12326.6 133556.2_45722001_2 - 0.047 13.5 0.1 0.047 13.5 0.1 1.1 1 0 0 1 1 1 0 N-glycosylation protein Presenilin PF01080.15 133556.2_45722001_2 - 1.2 7.7 4.3 1.2 7.6 4.3 1.1 1 0 0 1 1 1 0 Presenilin OATP PF03137.18 133556.2_45722001_2 - 8.6 4.4 9.1 10 4.2 9.1 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Folate_carrier PF01770.16 133556.2_45722001_2 - 9.2 4.7 6.2 11 4.5 6.2 1.1 1 0 0 1 1 1 0 Reduced folate carrier RNA_pol_Rpc4 PF05132.12 133556.2_45722001_3 - 0.0087 16.4 9.2 0.01 16.2 9.2 1.1 1 0 0 1 1 1 1 RNA polymerase III RPC4 EOS1 PF12326.6 133556.2_45722001_3 - 0.021 14.6 0.2 0.021 14.6 0.2 1.1 1 0 0 1 1 1 0 N-glycosylation protein CLN3 PF02487.15 133556.2_45722001_3 - 2.3 7.0 3.4 2.6 6.8 3.4 1.1 1 0 0 1 1 1 0 CLN3 protein 7tm_1 PF00001.19 133556.2_45722001_3 - 4.3 6.3 7.9 5.6 6.0 7.9 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) HEAT PF02985.20 146879.1_26227120_1 - 1.4e-12 46.5 0.6 7.5e-05 22.5 0.0 3.7 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.4 146879.1_26227120_1 - 2.6e-05 24.4 1.0 0.00085 19.5 0.8 2.7 1 1 0 1 1 1 1 HEAT repeats HEAT_EZ PF13513.4 146879.1_26227120_1 - 0.00016 21.9 0.7 0.98 9.8 0.0 3.1 2 0 0 2 2 2 2 HEAT-like repeat RTP1_C1 PF10363.7 146879.1_26227120_1 - 0.014 15.4 0.0 0.028 14.4 0.0 1.4 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.5 146879.1_26227120_1 - 0.23 11.3 0.0 0.62 9.9 0.0 1.6 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.4 146879.1_26227120_3 - 0.079 13.3 10.6 0.19 12.1 0.1 4.0 5 0 0 5 5 5 0 HEAT-like repeat HEAT_PBS PF03130.14 146879.1_26227120_3 - 0.18 12.4 3.8 0.75 10.5 0.1 3.4 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat RRM_1 PF00076.20 148527.1_26229120_1 - 4.8e-42 141.5 0.1 3.2e-16 58.8 0.0 3.9 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 148527.1_26229120_1 - 4.1e-06 26.7 0.0 0.18 11.8 0.0 3.5 3 0 0 3 3 3 2 RNA recognition motif Nup35_RRM_2 PF14605.4 148527.1_26229120_1 - 0.01 15.7 0.0 0.39 10.6 0.0 3.0 4 0 0 4 4 4 0 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.4 148527.1_26229120_1 - 0.012 15.1 0.0 0.31 10.5 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TF_Otx PF03529.11 148527.1_26229120_1 - 8.3 6.8 14.3 0.99 9.7 3.3 2.6 2 0 0 2 2 2 0 Otx1 transcription factor TctB PF07331.9 148527.1_26229120_2 - 0.05 13.7 0.1 0.094 12.9 0.1 1.4 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family Spc7 PF08317.9 104213.1_26222120_1 - 0.0091 14.8 0.9 0.014 14.2 0.9 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein SlyX PF04102.10 104213.1_26222120_1 - 0.032 14.7 7.7 0.13 12.8 5.6 2.1 2 0 0 2 2 2 0 SlyX HeLo PF14479.4 104213.1_26222120_1 - 0.036 13.8 0.7 0.051 13.3 0.7 1.1 1 0 0 1 1 1 0 Prion-inhibition and propagation Helo_like_N PF17111.3 104213.1_26222120_1 - 0.07 12.3 2.2 0.33 10.2 0.0 2.0 2 0 0 2 2 2 0 Fungal N-terminal domain of STAND proteins WXG100 PF06013.10 104213.1_26222120_1 - 0.13 12.4 2.5 3.5 7.8 0.9 2.2 2 0 0 2 2 2 0 Proteins of 100 residues with WXG HemX PF04375.12 104213.1_26222120_1 - 0.16 11.1 3.1 0.23 10.6 3.1 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase IncA PF04156.12 104213.1_26222120_1 - 0.77 9.4 10.6 1.7 8.2 10.6 1.6 1 1 0 1 1 1 0 IncA protein DivIC PF04977.13 104213.1_26222120_1 - 1.7 8.3 4.3 3.5 7.3 4.3 1.4 1 0 0 1 1 1 0 Septum formation initiator Integrin_alpha2 PF08441.10 073107.1_26229120_2 - 1.1e-48 166.2 7.3 1.6e-48 165.7 7.3 1.1 1 0 0 1 1 1 1 Integrin alpha VWA PF00092.26 073107.1_26229120_2 - 1.6e-39 135.9 0.2 2.7e-39 135.1 0.2 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain FG-GAP PF01839.21 073107.1_26229120_2 - 4.2e-19 68.2 3.0 3.2e-08 33.4 0.3 3.5 3 0 0 3 3 3 3 FG-GAP repeat VWA_2 PF13519.4 073107.1_26229120_2 - 1.8e-13 50.9 0.0 3.6e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VCBS PF13517.4 073107.1_26229120_2 - 2.5e-05 24.7 7.0 0.001 19.5 1.6 3.2 3 0 0 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.4 073107.1_26229120_2 - 0.0011 19.0 5.1 0.46 10.6 0.0 4.3 5 0 0 5 5 5 2 FG-GAP repeat Integrin_alpha PF00357.18 073107.1_26229120_2 - 0.0032 17.2 2.2 0.0077 16.0 2.2 1.7 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region A_deamin PF02137.16 021486.1_32929120_2 - 6e-114 380.7 0.0 7.7e-114 380.4 0.0 1.1 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain dsrm PF00035.24 021486.1_32929120_2 - 2e-26 92.3 0.0 8.2e-13 48.7 0.0 2.6 2 0 0 2 2 2 2 Double-stranded RNA binding motif V-set PF07686.15 136332.1_26226120_1 - 5e-09 36.2 0.0 9.4e-09 35.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Bromodomain PF00439.23 037970.1_32929120_3 - 8.2e-36 121.8 2.5 2e-20 72.5 0.1 2.3 2 0 0 2 2 2 2 Bromodomain BET PF17035.3 037970.1_32929120_3 - 5.5e-28 96.8 0.1 5.5e-28 96.8 0.1 2.0 2 0 0 2 2 2 1 Bromodomain extra-terminal - transcription regulation AF-4 PF05110.11 037970.1_32929120_3 - 0.00095 17.3 50.5 0.019 13.0 23.1 2.3 2 0 0 2 2 2 2 AF-4 proto-oncoprotein Sigma70_ner PF04546.11 037970.1_32929120_3 - 0.0072 16.1 9.2 0.0072 16.1 9.2 1.8 2 0 0 2 2 2 1 Sigma-70, non-essential region DUF4667 PF15700.3 037970.1_32929120_3 - 0.048 13.6 17.0 0.067 13.2 0.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) CDK2AP PF09806.7 037970.1_32929120_3 - 1.1 9.1 9.1 6.7 6.6 4.3 2.5 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein RRN3 PF05327.9 037970.1_32929120_3 - 1.7 7.0 5.6 3.2 6.1 5.6 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CENP-B_dimeris PF09026.8 037970.1_32929120_3 - 2.9 8.2 12.9 9.1 6.6 12.9 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RRM_1 PF00076.20 148519.1_26229120_1 - 3.7e-41 138.7 0.0 3e-16 58.8 0.0 3.6 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.3 148519.1_26229120_1 - 0.0012 18.8 0.0 0.17 11.9 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif Nup35_RRM_2 PF14605.4 148519.1_26229120_1 - 0.0063 16.3 0.0 0.38 10.6 0.0 3.3 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.4 148519.1_26229120_1 - 0.0075 15.7 0.0 0.26 10.8 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TctB PF07331.9 148519.1_26229120_2 - 0.048 13.8 0.1 0.09 12.9 0.1 1.4 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family p450 PF00067.20 134994.1_26225120_1 - 2.6e-43 148.3 0.0 3.4e-43 147.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.20 134994.1_26225120_3 - 2.6e-50 171.4 0.2 3.5e-50 171.0 0.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 Pkinase_Tyr PF07714.15 010237.3_32929001_3 - 6.2e-96 320.5 0.0 8.3e-96 320.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 010237.3_32929001_3 - 2e-50 171.5 0.0 2.8e-50 171.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 010237.3_32929001_3 - 5.1e-25 87.2 0.4 1.6e-24 85.6 0.3 1.9 2 0 0 2 2 2 1 SH2 domain SH3_1 PF00018.26 010237.3_32929001_3 - 1.7e-13 49.8 0.0 4e-13 48.6 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.4 010237.3_32929001_3 - 6.7e-09 35.3 0.0 1.2e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 010237.3_32929001_3 - 8.3e-09 34.9 0.0 1.5e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain TSP_1 PF00090.17 001358799.1_29629001_1 - 7.8e-151 490.1 453.7 1.7e-12 47.2 9.4 31.7 27 1 0 27 27 27 25 Thrombospondin type 1 domain VWD PF00094.23 001358799.1_29629001_1 - 3.8e-83 277.3 0.0 8.7e-32 110.4 0.0 3.3 3 0 0 3 3 3 3 von Willebrand factor type D domain TIL PF01826.15 001358799.1_29629001_1 - 4.8e-61 202.7 330.6 1.5e-09 37.8 14.0 44.3 45 7 6 51 51 51 16 Trypsin Inhibitor like cysteine rich domain Ldl_recept_a PF00057.16 001358799.1_29629001_1 - 8.8e-44 147.3 138.5 5e-13 48.9 9.5 24.2 24 0 0 24 24 24 11 Low-density lipoprotein receptor domain class A C8 PF08742.9 001358799.1_29629001_1 - 9.5e-43 144.4 40.9 1.4e-16 60.5 11.7 8.6 6 0 0 6 6 6 3 C8 domain F5_F8_type_C PF00754.23 001358799.1_29629001_1 - 7.8e-19 67.9 0.0 1.4e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 F5/8 type C domain Pacifastin_I PF05375.11 001358799.1_29629001_1 - 1.2e-15 56.8 231.9 1.8e-06 27.5 4.7 23.8 22 0 0 22 22 22 13 Pacifastin inhibitor (LCMII) VWC PF00093.16 001358799.1_29629001_1 - 9e-06 25.8 46.4 2.1e-05 24.6 13.0 41.9 34 12 7 42 42 42 13 von Willebrand factor type C domain MHC_I PF00129.16 010189.3_32924001_1 - 4e-57 192.5 0.0 5.3e-57 192.1 0.0 1.1 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 010189.3_32924001_1 - 1.5e-10 41.3 0.0 2.9e-10 40.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.3 010189.3_32924001_1 - 0.00016 21.1 0.1 0.00022 20.6 0.1 1.2 1 0 0 1 1 1 1 MHC-I family domain Ig_3 PF13927.4 010189.3_32924001_1 - 0.0013 19.1 0.1 0.0065 16.9 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain Cytochrome_B PF00033.17 010189.3_32924001_1 - 0.052 13.2 0.1 0.092 12.4 0.1 1.3 1 0 0 1 1 1 0 Cytochrome b/b6/petB MHC_II_beta PF00969.17 010189.3_32924001_1 - 0.13 12.2 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 Class II histocompatibility antigen, beta domain Glyco_transf_29 PF00777.16 001037313.1_39722001_1 - 2.2e-62 210.7 0.0 2.7e-62 210.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) DNA_primase_S PF01896.17 001145865.1_06524001_2 - 1.2e-58 198.1 1.3 1.7e-58 197.6 1.3 1.2 1 0 0 1 1 1 1 DNA primase small subunit FGGY_N PF00370.19 177352.4_32926001_2 - 9.6e-49 166.0 0.2 1.1e-47 162.5 0.2 2.0 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.14 177352.4_32926001_2 - 4.3e-33 114.6 0.1 8.4e-33 113.6 0.1 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain G-alpha PF00503.18 008138.4_32925001_3 - 1.1e-124 416.1 2.7 1.4e-124 415.8 2.7 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.19 008138.4_32925001_3 - 7e-17 61.3 0.1 2.1e-12 46.7 0.0 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.10 008138.4_32925001_3 - 6.6e-05 22.2 1.8 0.062 12.5 0.9 2.2 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.11 008138.4_32925001_3 - 0.0006 19.9 0.1 1.2 9.2 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.4 008138.4_32925001_3 - 0.042 14.1 0.0 0.08 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain V-set PF07686.15 027644.1_32924120_1 - 4e-18 65.4 0.4 1.1e-08 35.1 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.4 027644.1_32924120_1 - 9.5e-12 45.2 0.1 2.7e-08 34.2 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.14 027644.1_32924120_1 - 4.5e-10 39.3 0.1 1.6e-05 24.7 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.4 027644.1_32924120_1 - 4.1e-07 30.1 0.8 0.00014 22.0 0.1 3.2 2 1 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 027644.1_32924120_1 - 0.0004 20.4 0.2 0.25 11.4 0.1 2.8 2 1 0 2 2 2 2 Immunoglobulin domain Pkinase PF00069.23 102731.1_32926120_1 - 5.8e-14 51.9 0.0 8.2e-14 51.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 102731.1_32926120_1 - 1e-08 34.7 0.0 1.4e-08 34.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 102731.1_32926120_2 - 1.3e-25 90.1 0.0 1.9e-25 89.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 102731.1_32926120_2 - 9e-13 48.0 0.0 1.3e-12 47.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Arrestin_N PF00339.27 027876.1_32924120_2 - 1.5e-17 63.9 0.0 8.3e-17 61.5 0.0 2.0 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.20 027876.1_32924120_2 - 0.0006 20.1 0.0 0.83 9.9 0.0 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Vps26 PF03643.13 027876.1_32924120_2 - 0.0042 16.0 0.0 0.0059 15.5 0.0 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_C PF02752.20 027876.1_32924120_3 - 0.0029 17.8 0.0 0.005 17.1 0.0 1.2 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Pkinase PF00069.23 031338.1_45725001_1 - 2e-64 217.4 0.0 9e-64 215.2 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 031338.1_45725001_1 - 3.7e-33 114.8 0.0 2.6e-31 108.7 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.4 031338.1_45725001_1 - 1.6e-07 30.9 0.0 2.2e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.21 031338.1_45725001_1 - 0.13 12.0 0.2 1.6 8.5 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.9 031338.1_45725001_1 - 0.23 10.3 0.4 3.9 6.3 0.0 2.2 2 0 0 2 2 2 0 Seadornavirus VP7 4_1_CTD PF05902.11 001358754.1_32928001_1 - 2.7e-41 139.9 5.3 2.7e-41 139.9 5.3 2.1 2 1 0 2 2 2 1 4.1 protein C-terminal domain (CTD) FERM_C PF09380.8 001358754.1_32928001_1 - 1.1e-23 83.3 0.0 1.9e-23 82.5 0.0 1.4 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.8 001358754.1_32928001_1 - 4.5e-20 71.2 0.1 1.1e-19 70.0 0.1 1.7 1 0 0 1 1 1 1 FERM N-terminal domain FA PF08736.9 001358754.1_32928001_1 - 1e-18 67.0 3.9 3.6e-18 65.2 3.9 2.0 1 0 0 1 1 1 1 FERM adjacent (FA) FERM_M PF00373.16 001358754.1_32928001_1 - 3.4e-18 66.0 0.1 1.2e-17 64.3 0.0 2.0 2 0 0 2 2 2 1 FERM central domain Pkinase PF00069.23 001323289.1_26229001_1 - 4.8e-74 248.9 0.0 6.7e-74 248.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001323289.1_26229001_1 - 3.1e-33 115.0 0.0 4.7e-33 114.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.20 001323289.1_26229001_1 - 0.028 13.9 0.8 0.049 13.1 0.8 1.2 1 0 0 1 1 1 0 RIO1 family FTA2 PF13095.4 001323289.1_26229001_1 - 0.036 13.6 0.1 4.6 6.7 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 BTB_2 PF02214.20 001289671.1_32924001_2 - 1.4e-22 79.8 0.0 2.4e-22 79.0 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.29 001289671.1_32924001_2 - 0.079 13.1 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 BTB/POZ domain EGF_CA PF07645.13 021474.3_32924001_3 - 3.3e-48 161.5 85.0 3.1e-11 43.2 5.8 8.2 8 0 0 8 8 8 6 Calcium-binding EGF domain cEGF PF12662.5 021474.3_32924001_3 - 2.3e-36 123.2 53.2 4e-10 39.3 0.4 7.7 8 0 0 8 8 8 6 Complement Clr-like EGF-like FXa_inhibition PF14670.4 021474.3_32924001_3 - 2.1e-13 50.2 92.6 1.4e-06 28.3 7.6 8.8 8 1 0 8 8 8 4 Coagulation Factor Xa inhibitory site EGF_3 PF12947.5 021474.3_32924001_3 - 1e-07 31.9 63.9 8.3e-05 22.6 6.2 7.3 7 1 0 7 7 7 5 EGF domain EGF PF00008.25 021474.3_32924001_3 - 0.00016 21.7 88.0 0.0013 18.9 7.9 8.2 8 0 0 8 8 8 4 EGF-like domain hEGF PF12661.5 021474.3_32924001_3 - 0.0027 18.2 84.8 0.0054 17.2 4.0 9.9 11 0 0 11 11 11 5 Human growth factor-like EGF Aconitase PF00330.18 017321.1_45728001_3 - 5.2e-181 602.5 0.0 7.7e-181 601.9 0.0 1.2 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.17 017321.1_45728001_3 - 2.9e-45 153.7 0.0 6.8e-44 149.3 0.0 2.2 2 0 0 2 2 2 1 Aconitase C-terminal domain Annexin PF00191.18 013469.2_32925001_3 - 1.1e-101 332.8 11.8 6.4e-26 90.1 0.3 4.2 4 0 0 4 4 4 4 Annexin Myb_DNA-bind_7 PF15963.3 013469.2_32925001_3 - 0.12 12.1 0.2 19 5.1 0.0 3.0 3 0 0 3 3 3 0 Myb DNA-binding like UCH PF00443.27 001038589.2_32929001_3 - 1.5e-49 168.7 0.8 2e-49 168.3 0.8 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.4 001038589.2_32929001_3 - 1.7e-14 54.0 4.1 3.2e-14 53.1 4.1 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.21 001038589.2_32929001_3 - 0.051 13.2 0.0 0.095 12.3 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin family p450 PF00067.20 001347254.1_26229001_2 - 1.1e-99 334.2 0.3 1.4e-99 333.8 0.3 1.1 1 0 0 1 1 1 1 Cytochrome P450 UQ_con PF00179.24 001282161.1_26224001_2 - 1.3e-50 170.6 0.1 2.1e-50 169.9 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.20 001282161.1_26224001_2 - 0.0023 18.1 0.1 0.0039 17.3 0.1 1.3 1 0 0 1 1 1 1 RWD domain Arrestin_N PF00339.27 006472.5_26226001_3 - 1.4e-23 83.5 0.1 2.1e-23 82.9 0.1 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.20 006472.5_26226001_3 - 2.1e-11 44.2 0.0 1.4e-10 41.5 0.0 2.0 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain p450 PF00067.20 001347251.1_26229001_2 - 1e-99 334.3 0.3 1.4e-99 333.9 0.3 1.1 1 0 0 1 1 1 1 Cytochrome P450 AKNA PF12443.6 001108668.1_45729001_1 - 1.6e-34 118.3 0.8 8.3e-34 116.0 0.8 2.4 1 0 0 1 1 1 1 AT-hook-containing transcription factor LRR_8 PF13855.4 213761.1_49826001_2 - 4.7e-39 131.8 48.0 3.7e-12 45.7 7.5 8.7 6 1 2 9 9 9 8 Leucine rich repeat LRR_4 PF12799.5 213761.1_49826001_2 - 8.9e-24 83.0 49.0 7.2e-06 26.1 3.6 9.8 8 1 2 10 10 10 8 Leucine Rich repeats (2 copies) TIR PF01582.18 213761.1_49826001_2 - 6.5e-23 81.3 0.2 1.3e-22 80.3 0.2 1.4 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.4 213761.1_49826001_2 - 3.4e-10 40.0 0.0 1.1e-09 38.4 0.0 1.9 1 0 0 1 1 1 1 TIR domain LRR_9 PF14580.4 213761.1_49826001_2 - 3.4e-08 33.0 12.4 0.0053 16.1 0.1 4.6 2 2 3 5 5 5 3 Leucine-rich repeat LRR_1 PF00560.31 213761.1_49826001_2 - 2.3e-06 27.1 41.0 0.05 13.9 1.4 12.3 11 2 0 11 11 11 3 Leucine Rich Repeat LRR_5 PF13306.4 213761.1_49826001_2 - 3e-06 27.1 11.5 1.8e-05 24.6 0.1 4.5 2 2 1 3 3 3 2 Leucine rich repeats (6 copies) LRRCT PF01463.22 213761.1_49826001_2 - 0.0014 18.8 0.1 0.0069 16.7 0.1 2.3 2 0 0 2 2 2 1 Leucine rich repeat C-terminal domain Pentapeptide_4 PF13599.4 213761.1_49826001_2 - 0.035 14.1 5.0 0.99 9.4 2.0 3.5 2 1 0 2 2 2 0 Pentapeptide repeats (9 copies) DUF1863 PF08937.9 213761.1_49826001_2 - 0.18 12.0 0.8 0.81 9.9 0.8 2.0 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) p450 PF00067.20 001347253.1_26229001_2 - 1.1e-99 334.2 0.3 1.5e-99 333.8 0.3 1.1 1 0 0 1 1 1 1 Cytochrome P450 ATP-gua_Ptrans PF00217.17 135752.1_26225120_1 - 3.2e-38 131.6 0.0 4.3e-38 131.2 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.13 135752.1_26225120_2 - 1.1e-19 70.5 0.0 1.9e-19 69.7 0.0 1.4 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain ATP-gua_Ptrans PF00217.17 135752.1_26225120_3 - 5.9e-47 160.2 0.0 8.2e-47 159.7 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain Asparaginase_2 PF01112.16 033655.1_26225120_2 - 2.6e-25 89.0 0.1 3.5e-25 88.6 0.1 1.1 1 0 0 1 1 1 1 Asparaginase Asparaginase_2 PF01112.16 033655.1_26225120_3 - 3.4e-41 141.1 0.0 4.5e-41 140.7 0.0 1.1 1 0 0 1 1 1 1 Asparaginase NOT2_3_5 PF04153.16 037615.1_26228120_2 - 2.1e-30 105.4 0.2 3.5e-30 104.6 0.2 1.4 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family IRF-3 PF10401.7 046000.2_26229120_1 - 4.7e-60 202.3 1.0 4.8e-60 202.3 0.1 1.5 2 0 0 2 2 2 1 Interferon-regulatory factor 3 IRF PF00605.15 046000.2_26229120_1 - 8.2e-42 141.6 0.2 1.2e-41 141.1 0.2 1.3 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor GP41 PF00517.15 134505.1_26224120_1 - 0.0028 17.4 1.5 0.0028 17.4 1.5 1.8 2 0 0 2 2 2 1 Retroviral envelope protein zf-H2C2_2 PF13465.4 178733.5_32927001_3 - 7.9e-92 297.8 103.6 4.1e-09 36.3 0.7 14.5 14 0 0 14 14 14 13 Zinc-finger double domain zf-C2H2 PF00096.24 178733.5_32927001_3 - 8.3e-60 195.9 105.5 8.7e-05 22.6 1.0 13.8 13 0 0 13 13 13 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 178733.5_32927001_3 - 6.3e-29 98.0 109.0 0.012 16.2 0.8 14.1 14 0 0 14 14 13 13 C2H2-type zinc finger KRAB PF01352.25 178733.5_32927001_3 - 7.2e-24 83.1 0.7 1.2e-23 82.3 0.7 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 178733.5_32927001_3 - 6.4e-15 54.5 92.0 0.01 15.6 0.2 14.3 13 1 0 13 13 13 11 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 178733.5_32927001_3 - 2.1e-14 53.2 73.5 0.0092 16.0 4.6 9.5 4 2 7 11 11 11 10 Zinc ribbon domain zf-C2H2_jaz PF12171.6 178733.5_32927001_3 - 0.00013 22.0 66.9 0.017 15.3 0.2 12.2 13 0 0 13 13 13 5 Zinc-finger double-stranded RNA-binding C1_4 PF07975.10 178733.5_32927001_3 - 0.0059 16.7 65.7 0.3 11.3 6.3 9.6 1 1 6 10 10 10 5 TFIIH C1-like domain zf-met PF12874.5 178733.5_32927001_3 - 0.0074 16.5 0.9 0.0074 16.5 0.9 8.9 13 0 0 13 13 11 1 Zinc-finger of C2H2 type XPA_N PF01286.16 178733.5_32927001_3 - 0.063 13.2 70.1 6.2 6.8 0.1 13.6 14 0 0 14 14 14 0 XPA protein N-terminal DUF3741 PF12552.6 178733.5_32927001_3 - 0.23 11.3 7.7 1e+02 2.8 0.0 6.9 8 1 1 9 9 9 0 Protein of unknown function (DUF3741) DUF3268 PF11672.6 178733.5_32927001_3 - 5.4 7.3 42.9 0.32 11.2 0.9 6.8 3 1 4 8 8 8 0 zinc-finger-containing domain V1R PF03402.12 001167484.1_22422001_1 - 9.7e-37 126.9 11.7 1.4e-36 126.4 11.7 1.1 1 0 0 1 1 1 1 Vomeronasal organ pheromone receptor family, V1R 7tm_1 PF00001.19 001167484.1_22422001_1 - 9.1e-10 38.1 11.7 1.2e-09 37.7 11.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.11 001167484.1_22422001_1 - 9.6e-10 37.9 13.4 1.3e-09 37.5 13.4 1.0 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Pex24p PF06398.9 001167484.1_22422001_1 - 0.024 13.5 4.7 0.049 12.5 4.7 1.5 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin zf-C2H2 PF00096.24 001169077.1_40426001_1 - 5.3e-26 89.4 53.8 4.9e-06 26.6 2.8 7.3 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001169077.1_40426001_1 - 4.5e-16 58.0 50.3 0.0021 18.6 0.9 7.5 7 0 0 7 7 7 6 C2H2-type zinc finger zf-H2C2_2 PF13465.4 001169077.1_40426001_1 - 9.9e-15 54.1 47.9 2.7e-07 30.6 1.2 7.9 8 0 0 8 8 8 4 Zinc-finger double domain zf-H2C2_5 PF13909.4 001169077.1_40426001_1 - 5.8e-05 22.6 34.4 8.5e-05 22.1 3.9 4.6 5 0 0 5 5 5 2 C2H2-type zinc-finger domain DUF3268 PF11672.6 001169077.1_40426001_1 - 0.00024 21.3 14.4 0.007 16.6 0.8 2.6 2 1 0 2 2 2 2 zinc-finger-containing domain FYVE PF01363.19 001169077.1_40426001_1 - 0.0022 17.9 20.4 0.66 10.0 0.5 5.2 5 0 0 5 5 5 2 FYVE zinc finger Actin_micro PF17003.3 001169077.1_40426001_1 - 0.07 12.2 6.4 2.2 7.2 0.4 3.6 3 1 1 4 4 4 0 Putative actin-like family GAGA PF09237.9 001169077.1_40426001_1 - 0.075 12.7 7.9 1.6 8.5 0.6 3.0 2 1 0 2 2 2 0 GAGA factor zf-C2H2_7 PF15269.4 001169077.1_40426001_1 - 0.21 11.6 17.6 0.34 10.9 0.5 3.8 3 1 0 3 3 3 0 Zinc-finger zf-C2HC_2 PF13913.4 001169077.1_40426001_1 - 6.6 6.6 8.9 6.8 6.6 0.8 3.7 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.6 001169077.1_40426001_1 - 8.6 6.7 44.3 0.86 9.9 2.0 6.1 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding RhoGAP PF00620.25 001169082.1_40425001_1 - 5.2e-38 130.1 0.2 9.6e-38 129.2 0.2 1.4 1 0 0 1 1 1 1 RhoGAP domain Bap31 PF05529.10 001281944.1_31322001_1 - 3.9e-77 258.3 7.5 5.3e-77 257.8 7.5 1.2 1 0 0 1 1 1 1 B-cell receptor-associated protein 31-like Atg14 PF10186.7 001281944.1_31322001_1 - 0.0038 16.2 10.0 0.0051 15.8 10.0 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Imm3 PF14425.4 001281944.1_31322001_1 - 0.019 14.9 3.1 0.033 14.1 3.1 1.3 1 0 0 1 1 1 0 Immunity protein Imm3 DUF996 PF06195.11 001281944.1_31322001_1 - 0.026 14.7 2.3 0.078 13.1 2.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF996) GAS PF13851.4 001281944.1_31322001_1 - 0.026 13.7 19.3 0.04 13.2 19.3 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding LMF1 PF06762.12 001281944.1_31322001_1 - 0.045 12.7 0.4 0.053 12.4 0.4 1.1 1 0 0 1 1 1 0 Lipase maturation factor PV-1 PF06637.9 001281944.1_31322001_1 - 0.16 10.6 14.5 0.24 10.0 14.5 1.3 1 0 0 1 1 1 0 PV-1 protein (PLVAP) Lebercilin PF15619.4 001281944.1_31322001_1 - 0.16 11.5 20.2 0.054 13.0 12.0 2.2 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Spc7 PF08317.9 001281944.1_31322001_1 - 0.2 10.4 18.4 0.27 9.9 18.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Cpta_toxin PF07254.10 001281944.1_31322001_1 - 0.25 11.2 2.0 0.71 9.7 0.1 2.1 1 1 1 2 2 2 0 Membrane-bound toxin component of toxin-antitoxin system Rootletin PF15035.4 001281944.1_31322001_1 - 0.29 11.1 16.6 1.5 8.8 7.7 2.4 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion NicO PF03824.14 001281944.1_31322001_1 - 0.4 9.8 3.0 1.4 8.0 2.0 2.2 1 1 0 1 1 1 0 High-affinity nickel-transport protein DUF3498 PF12004.6 001281944.1_31322001_1 - 0.4 9.7 9.9 0.53 9.3 9.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3498) Sec34 PF04136.13 001281944.1_31322001_1 - 0.48 10.2 13.7 0.041 13.6 5.5 2.2 1 1 1 2 2 2 0 Sec34-like family APG6 PF04111.10 001281944.1_31322001_1 - 0.58 9.4 21.1 0.63 9.2 20.4 1.4 1 1 0 1 1 1 0 Autophagy protein Apg6 FUSC PF04632.10 001281944.1_31322001_1 - 0.6 8.5 3.3 0.88 7.9 3.3 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family TolA_bind_tri PF16331.3 001281944.1_31322001_1 - 0.87 9.6 7.9 6.8 6.7 2.3 2.5 2 0 0 2 2 2 0 TolA binding protein trimerisation DUF948 PF06103.9 001281944.1_31322001_1 - 1.5 9.0 13.1 0.85 9.8 0.7 3.6 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) JIP_LZII PF16471.3 001281944.1_31322001_1 - 1.5 8.9 14.6 3.8 7.6 0.1 3.4 3 1 0 3 3 3 0 JNK-interacting protein leucine zipper II CENP-H PF05837.10 001281944.1_31322001_1 - 2.2 8.6 19.2 0.082 13.2 8.3 2.2 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DivIC PF04977.13 001281944.1_31322001_1 - 2.4 7.9 13.5 0.98 9.1 4.4 3.1 3 0 0 3 3 3 0 Septum formation initiator LMBR1 PF04791.14 001281944.1_31322001_1 - 2.7 6.6 11.7 4.3 6.0 11.7 1.4 1 1 0 1 1 1 0 LMBR1-like membrane protein DUF972 PF06156.11 001281944.1_31322001_1 - 2.8 8.5 16.2 67 4.0 6.5 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF730 PF05325.9 001281944.1_31322001_1 - 3.3 7.6 8.3 0.96 9.3 4.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF730) DUF4140 PF13600.4 001281944.1_31322001_1 - 3.4 8.0 9.3 0.46 10.8 3.3 2.2 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF724 PF05266.12 001281944.1_31322001_1 - 4.5 6.9 17.6 35 4.0 17.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF724) DUF342 PF03961.11 001281944.1_31322001_1 - 5.7 5.3 13.6 14 4.0 13.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF342) IncA PF04156.12 001281944.1_31322001_1 - 6.1 6.5 20.6 20 4.8 20.6 1.8 1 1 0 1 1 1 0 IncA protein Cnn_1N PF07989.9 001281944.1_31322001_1 - 9.8 6.3 18.5 3.8 7.6 10.1 2.9 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 RhoGAP PF00620.25 001243543.1_49825001_2 - 3e-36 124.4 0.1 4.9e-36 123.7 0.1 1.3 1 0 0 1 1 1 1 RhoGAP domain CENP-N PF05238.11 001243543.1_49825001_2 - 0.11 11.7 0.1 0.17 11.0 0.1 1.2 1 0 0 1 1 1 0 Kinetochore protein CHL4 like Spc7 PF08317.9 001358918.1_32927001_3 - 0.00039 19.3 18.0 0.00039 19.3 18.0 4.3 1 1 2 4 4 4 2 Spc7 kinetochore protein UCR_hinge PF02320.14 001358918.1_32927001_3 - 2.1 8.5 10.5 2 8.6 7.5 2.6 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein Reo_sigmaC PF04582.10 001358918.1_32927001_3 - 4.4 6.5 7.3 1.1 8.4 0.5 2.9 2 1 2 4 4 4 0 Reovirus sigma C capsid protein COE1_DBD PF16422.3 001164534.1_32324001_1 - 4.3e-130 431.9 3.7 5.6e-130 431.5 3.7 1.1 1 0 0 1 1 1 1 Transcription factor COE1 DNA-binding domain COE1_HLH PF16423.3 001164534.1_32324001_1 - 1.5e-34 117.3 2.0 7.8e-28 95.8 0.3 2.6 2 0 0 2 2 2 2 Transcription factor COE1 helix-loop-helix domain TIG PF01833.22 001164534.1_32324001_1 - 8e-12 44.9 0.1 8e-12 44.9 0.1 2.3 2 0 0 2 2 2 1 IPT/TIG domain Pericardin_rpt PF07054.9 001164534.1_32324001_1 - 0.07 13.1 0.1 0.3 11.1 0.1 2.1 1 0 0 1 1 1 0 Pericardin like repeat DZF PF07528.12 001164534.1_32324001_3 - 0.47 9.9 1.3 0.68 9.4 1.3 1.1 1 0 0 1 1 1 0 DZF domain TCL1_MTCP1 PF01840.15 001194094.1_29624001_2 - 4.1e-27 94.0 1.2 7.8e-27 93.1 1.2 1.4 1 0 0 1 1 1 1 TCL1/MTCP1 family Bap31 PF05529.10 001038075.1_06523001_1 - 1.5e-69 233.5 7.3 1.9e-69 233.2 7.3 1.1 1 0 0 1 1 1 1 B-cell receptor-associated protein 31-like DAO_C PF16901.3 001038075.1_06523001_1 - 0.01 15.6 0.4 0.016 15.0 0.4 1.3 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase Exonuc_VII_L PF02601.13 001038075.1_06523001_1 - 0.014 14.8 5.6 0.017 14.6 5.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF3611 PF12263.6 001038075.1_06523001_1 - 0.037 13.8 1.1 0.062 13.0 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3611) DUF1640 PF07798.9 001038075.1_06523001_1 - 0.087 12.7 15.0 0.18 11.7 15.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) Syntaxin_2 PF14523.4 001038075.1_06523001_1 - 0.17 12.2 13.4 2.1 8.6 13.4 2.2 1 1 0 1 1 1 0 Syntaxin-like protein IncA PF04156.12 001038075.1_06523001_1 - 0.23 11.1 15.2 0.49 10.0 15.2 1.5 1 1 0 1 1 1 0 IncA protein APG6 PF04111.10 001038075.1_06523001_1 - 0.56 9.4 16.2 1 8.6 16.2 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 THOC7 PF05615.11 001038075.1_06523001_1 - 0.79 9.9 13.3 2 8.5 13.3 1.7 1 1 0 1 1 1 0 Tho complex subunit 7 Ribosomal_S20p PF01649.16 001038075.1_06523001_1 - 1.6 9.3 9.7 6.6 7.3 8.2 2.4 2 1 0 2 2 2 0 Ribosomal protein S20 HALZ PF02183.16 001038075.1_06523001_1 - 3.6 7.7 13.9 4.3 7.5 3.1 3.1 3 0 0 3 3 3 0 Homeobox associated leucine zipper DUF972 PF06156.11 001038075.1_06523001_1 - 4 8.0 16.9 7.8 7.0 3.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Collectrin PF16959.3 001194195.1_29624001_2 - 1.8e-65 219.3 0.4 4.6e-65 217.9 0.3 1.7 2 0 0 2 2 2 1 Renal amino acid transporter Chordopox_A13L PF05961.9 001194195.1_29624001_2 - 0.034 14.2 0.1 0.068 13.3 0.1 1.4 1 0 0 1 1 1 0 Chordopoxvirus A13L protein TMEM154 PF15102.4 001194195.1_29624001_2 - 0.06 13.1 0.0 0.092 12.5 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family DUF4381 PF14316.4 001194195.1_29624001_2 - 0.062 13.4 0.0 0.094 12.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) ECSCR PF15820.3 001194195.1_29624001_2 - 0.12 12.1 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator DUF4407 PF14362.4 001194195.1_29624001_2 - 0.14 11.4 0.1 0.23 10.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DNA_pol_delta_4 PF04081.11 001075183.2_06524001_2 - 0.15 12.3 1.3 0.27 11.5 1.3 1.3 1 0 0 1 1 1 0 DNA polymerase delta, subunit 4 LAT2 PF15703.3 001075183.2_06524001_3 - 2.5e-86 287.9 6.7 3.7e-86 287.4 6.7 1.2 1 0 0 1 1 1 1 Linker for activation of T-cells family member 2 Skp1_POZ PF03931.13 001246227.1_22421001_1 - 4.6e-11 42.6 0.0 6.3e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain RHD_DNA_bind PF00554.20 214161.1_49826001_3 - 1.7e-26 93.1 0.1 4.3e-26 91.7 0.1 1.7 1 1 0 1 1 1 1 Rel homology DNA-binding domain RHD_dimer PF16179.3 214161.1_49826001_3 - 3.8e-24 84.6 0.0 6.1e-24 83.9 0.0 1.3 1 0 0 1 1 1 1 Rel homology dimerisation domain TIG PF01833.22 214161.1_49826001_3 - 1.8e-07 31.0 0.0 4.8e-07 29.6 0.0 1.8 1 0 0 1 1 1 1 IPT/TIG domain Pkinase_Tyr PF07714.15 001266444.1_29629001_2 - 2.1e-91 305.7 0.0 3e-91 305.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.23 001266444.1_29629001_2 - 2.7e-46 157.9 0.0 4.4e-46 157.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.22 001266444.1_29629001_2 - 6.1e-20 70.9 0.0 1.1e-19 70.1 0.0 1.4 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 001266444.1_29629001_2 - 2.6e-14 52.4 0.0 5e-14 51.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain BTK PF00779.17 001266444.1_29629001_2 - 1.2e-13 50.5 2.0 2.3e-13 49.6 2.0 1.5 1 0 0 1 1 1 1 BTK motif PH PF00169.27 001266444.1_29629001_2 - 3.2e-13 50.0 0.3 7.9e-13 48.7 0.3 1.7 1 0 0 1 1 1 1 PH domain SH3_9 PF14604.4 001266444.1_29629001_2 - 5.3e-10 38.9 0.1 9.6e-10 38.0 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.15 001266444.1_29629001_2 - 2.1e-05 24.0 0.0 4.3e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.9 001266444.1_29629001_2 - 0.00075 19.6 0.1 0.0015 18.6 0.1 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain PH_8 PF15409.4 001266444.1_29629001_2 - 0.0025 17.9 0.1 0.0055 16.8 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain SH3_4 PF06347.11 001266444.1_29629001_2 - 0.073 12.8 0.1 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 Bacterial SH3 domain LAT2 PF15703.3 001243411.1_49824001_2 - 4e-89 297.0 5.4 5.3e-89 296.6 5.4 1.1 1 0 0 1 1 1 1 Linker for activation of T-cells family member 2 Interferon PF00143.17 001048159.1_22422001_1 - 2.4e-53 180.5 0.0 2.7e-53 180.3 0.0 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain DBB PF14545.4 001127508.1_39724001_1 - 4.4e-22 78.4 0.0 1e-21 77.2 0.0 1.7 1 0 0 1 1 1 1 Dof, BCAP, and BANK (DBB) motif, Ank_2 PF12796.5 001127508.1_39724001_1 - 0.021 15.3 0.0 0.046 14.2 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) TilS_C PF11734.6 001127508.1_39724001_1 - 0.12 11.7 0.0 0.35 10.2 0.0 1.7 1 0 0 1 1 1 0 TilS substrate C-terminal domain GIT_CC PF16559.3 001258440.1_26224001_2 - 0.074 13.0 0.6 0.15 12.0 0.6 1.4 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF4731 PF15875.3 001194612.1_29622001_1 - 0.16 12.1 0.3 0.26 11.4 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4731) KIAA1430 PF13879.4 001194612.1_29622001_2 - 4.4e-21 75.4 3.5 4.4e-21 75.4 3.5 2.1 2 0 0 2 2 2 1 KIAA1430 homologue PTR PF12789.5 001194612.1_29622001_2 - 0.014 15.3 0.6 0.028 14.4 0.6 1.5 1 0 0 1 1 1 0 Phage tail repeat like Interferon PF00143.17 001009193.1_22422001_1 - 2.7e-57 193.3 0.2 3e-57 193.1 0.2 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain Glyco_hydro_18 PF00704.26 001278838.1_22424001_1 - 1e-81 275.0 0.0 1.2e-81 274.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 BTB PF00651.29 001315701.1_49825001_1 - 7.6e-28 96.8 0.2 1.2e-27 96.2 0.2 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.4 001315701.1_49825001_1 - 1.7e-21 75.5 58.6 8.8e-07 29.0 0.5 6.9 8 0 0 8 8 7 5 Zinc-finger double domain zf-C2H2 PF00096.24 001315701.1_49825001_1 - 8.8e-19 66.7 56.1 3.3e-05 23.9 0.3 7.2 7 0 0 7 7 6 6 Zinc finger, C2H2 type zf-met PF12874.5 001315701.1_49825001_1 - 1.1e-11 44.6 34.9 0.00025 21.2 0.1 7.0 6 0 0 6 6 6 4 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.4 001315701.1_49825001_1 - 6.7e-11 41.9 53.0 0.012 16.3 1.1 7.5 7 0 0 7 7 7 5 C2H2-type zinc finger DZR PF12773.5 001315701.1_49825001_1 - 6.4e-06 26.0 21.0 0.53 10.2 4.7 4.8 4 0 0 4 4 4 4 Double zinc ribbon zf-C2H2_jaz PF12171.6 001315701.1_49825001_1 - 9.9e-06 25.6 19.0 0.16 12.2 1.2 6.0 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.3 001315701.1_49825001_1 - 0.0048 17.2 38.0 0.2 12.0 0.3 7.3 1 1 6 7 7 7 3 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_6 PF13912.4 001315701.1_49825001_1 - 0.0081 16.0 41.7 0.021 14.7 0.0 6.7 7 0 0 7 7 6 3 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001315701.1_49825001_1 - 0.03 14.3 1.3 0.03 14.3 1.3 6.1 4 3 3 7 7 7 0 Zinc ribbon domain DUF3342 PF11822.6 001315701.1_49825001_1 - 0.082 13.0 0.2 0.16 12.0 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) zinc_ribbon_15 PF17032.3 001315701.1_49825001_1 - 0.59 10.8 21.1 16 6.2 0.4 4.5 3 1 1 4 4 4 0 zinc-ribbon family DUF3268 PF11672.6 001315701.1_49825001_1 - 0.72 10.1 14.1 1.1 9.4 0.3 4.1 3 1 1 4 4 4 0 zinc-finger-containing domain GAGA PF09237.9 001315701.1_49825001_1 - 1.6 8.4 18.3 4.5 7.0 0.1 5.2 1 1 4 5 5 5 0 GAGA factor RhoGEF PF00621.18 001260772.1_29629001_3 - 4.3e-41 141.0 3.8 4.3e-41 141.0 3.8 1.7 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.27 001260772.1_29629001_3 - 1.3e-26 93.0 2.7 9.1e-15 54.9 0.4 3.2 3 0 0 3 3 3 2 PH domain RBD PF02196.13 001260772.1_29629001_3 - 1.3e-16 60.3 0.0 2.8e-16 59.3 0.0 1.6 1 0 0 1 1 1 1 Raf-like Ras-binding domain PH_9 PF15410.4 001260772.1_29629001_3 - 1.2e-10 41.6 0.3 2.8e-10 40.5 0.3 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PDZ PF00595.22 001260772.1_29629001_3 - 5.8e-07 29.6 0.0 1e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 001260772.1_29629001_3 - 0.0002 21.5 0.0 0.00047 20.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PH_11 PF15413.4 001260772.1_29629001_3 - 0.00053 20.2 0.6 0.0038 17.5 0.4 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain AAA_22 PF13401.4 001260772.1_29629001_3 - 0.093 12.9 0.9 17 5.6 0.0 2.8 3 0 0 3 3 3 0 AAA domain GIT_CC PF16559.3 047683.1_26223120_2 - 0.057 13.3 0.6 0.14 12.1 0.6 1.6 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Det1 PF09737.7 001321596.1_26225001_3 - 8.2e-194 644.2 0.9 1e-193 643.9 0.9 1.1 1 0 0 1 1 1 1 De-etiolated protein 1 Det1 Det1 PF09737.7 026645.2_26224120_1 - 1.6e-64 218.3 0.1 2.2e-64 217.9 0.1 1.1 1 0 0 1 1 1 1 De-etiolated protein 1 Det1 Det1 PF09737.7 026645.2_26224120_3 - 1.8e-95 320.3 0.1 2.6e-95 319.8 0.1 1.2 1 0 0 1 1 1 1 De-etiolated protein 1 Det1 DEAD PF00270.27 110335.1_32925120_1 - 1.3e-43 148.6 0.3 2.1e-43 148.0 0.3 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.29 110335.1_32925120_1 - 1.2e-26 93.2 0.6 1.2e-25 89.9 0.1 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.13 110335.1_32925120_1 - 2.6e-07 30.7 0.0 4.2e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.4 110335.1_32925120_1 - 0.0002 21.6 0.4 0.00043 20.5 0.1 1.7 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.4 110335.1_32925120_1 - 0.0042 16.7 0.0 0.0065 16.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.12 110335.1_32925120_1 - 0.11 12.2 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Helicase Myelin-PO_C PF10570.7 001321055.1_29624001_2 - 1.6e-36 124.4 8.8 2.5e-36 123.8 8.8 1.3 1 0 0 1 1 1 1 Myelin-PO cytoplasmic C-term p65 binding region V-set PF07686.15 001321055.1_29624001_2 - 7.4e-21 74.2 0.0 1.1e-20 73.6 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.4 001321055.1_29624001_2 - 7.5e-05 22.9 0.2 0.00076 19.6 0.2 2.2 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 001321055.1_29624001_2 - 0.00069 20.0 0.0 0.0016 18.9 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001321055.1_29624001_2 - 0.00097 19.1 0.3 0.0026 17.7 0.3 1.7 1 1 0 1 1 1 1 Immunoglobulin domain DUF1191 PF06697.10 001321055.1_29624001_2 - 0.0077 15.4 0.1 0.012 14.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1191) I-set PF07679.14 001321055.1_29624001_2 - 0.036 14.0 0.0 0.073 13.0 0.0 1.5 1 1 0 1 1 1 0 Immunoglobulin I-set domain Herpes_gE PF02480.14 001321055.1_29624001_2 - 0.066 11.8 0.5 0.23 10.0 0.6 1.7 1 1 1 2 2 2 0 Alphaherpesvirus glycoprotein E Protocadherin PF08374.9 001321055.1_29624001_2 - 0.074 12.9 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Protocadherin HAMP PF00672.23 001321055.1_29624001_2 - 0.094 12.8 0.1 0.19 11.9 0.1 1.4 1 0 0 1 1 1 0 HAMP domain Amnionless PF14828.4 001321055.1_29624001_2 - 0.15 10.7 0.0 0.2 10.3 0.0 1.1 1 0 0 1 1 1 0 Amnionless Myelin-PO_C PF10570.7 001321056.1_29624001_2 - 1.6e-36 124.4 8.8 2.5e-36 123.8 8.8 1.3 1 0 0 1 1 1 1 Myelin-PO cytoplasmic C-term p65 binding region V-set PF07686.15 001321056.1_29624001_2 - 7.4e-21 74.2 0.0 1.1e-20 73.6 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.4 001321056.1_29624001_2 - 7.5e-05 22.9 0.2 0.00076 19.6 0.2 2.2 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 001321056.1_29624001_2 - 0.00069 20.0 0.0 0.0016 18.9 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001321056.1_29624001_2 - 0.00097 19.1 0.3 0.0026 17.7 0.3 1.7 1 1 0 1 1 1 1 Immunoglobulin domain DUF1191 PF06697.10 001321056.1_29624001_2 - 0.0077 15.4 0.1 0.012 14.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1191) I-set PF07679.14 001321056.1_29624001_2 - 0.036 14.0 0.0 0.073 13.0 0.0 1.5 1 1 0 1 1 1 0 Immunoglobulin I-set domain Herpes_gE PF02480.14 001321056.1_29624001_2 - 0.066 11.8 0.5 0.23 10.0 0.6 1.7 1 1 1 2 2 2 0 Alphaherpesvirus glycoprotein E Protocadherin PF08374.9 001321056.1_29624001_2 - 0.074 12.9 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Protocadherin HAMP PF00672.23 001321056.1_29624001_2 - 0.094 12.8 0.1 0.19 11.9 0.1 1.4 1 0 0 1 1 1 0 HAMP domain Amnionless PF14828.4 001321056.1_29624001_2 - 0.15 10.7 0.0 0.2 10.3 0.0 1.1 1 0 0 1 1 1 0 Amnionless Myelin-PO_C PF10570.7 001079507.2_06524001_3 - 2.1e-34 117.6 8.7 3.9e-34 116.7 8.7 1.5 1 0 0 1 1 1 1 Myelin-PO cytoplasmic C-term p65 binding region V-set PF07686.15 001079507.2_06524001_3 - 1.7e-19 69.8 0.0 2.8e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.4 001079507.2_06524001_3 - 0.0011 19.1 0.2 0.011 15.9 0.2 2.3 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001079507.2_06524001_3 - 0.003 17.6 0.1 0.0093 16.0 0.1 1.8 1 1 0 1 1 1 1 Immunoglobulin domain DUF1191 PF06697.10 001079507.2_06524001_3 - 0.0041 16.3 0.2 0.0068 15.5 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1191) Ig_3 PF13927.4 001079507.2_06524001_3 - 0.0046 17.4 0.0 0.012 16.1 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001079507.2_06524001_3 - 0.059 13.3 0.0 0.13 12.2 0.0 1.6 1 1 0 1 1 1 0 Immunoglobulin I-set domain Mucin15 PF15672.3 001079507.2_06524001_3 - 0.098 12.0 0.4 0.15 11.4 0.4 1.2 1 0 0 1 1 1 0 Cell-membrane associated Mucin15 IncA PF04156.12 001079507.2_06524001_3 - 0.14 11.8 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 IncA protein Amnionless PF14828.4 001079507.2_06524001_3 - 0.16 10.7 0.0 0.23 10.2 0.0 1.1 1 0 0 1 1 1 0 Amnionless HAMP PF00672.23 001079507.2_06524001_3 - 0.46 10.6 1.7 0.45 10.7 0.2 1.7 2 0 0 2 2 2 0 HAMP domain Mito_carr PF00153.25 001320504.1_29626001_1 - 6.9e-15 54.6 0.1 3.6e-09 36.3 0.0 3.3 3 0 0 3 3 3 2 Mitochondrial carrier protein Mito_carr PF00153.25 001106488.3_45725001_1 - 3.9e-14 52.2 0.2 5.3e-09 35.8 0.0 3.1 3 0 0 3 3 3 2 Mitochondrial carrier protein PAM2 PF07145.13 001357470.1_32924001_3 - 2.3e-06 26.8 0.7 2.3e-06 26.8 0.7 1.9 2 0 0 2 2 2 1 Ataxin-2 C-terminal region Interferon PF00143.17 001009197.2_22422001_3 - 5.6e-56 189.0 0.3 7.3e-56 188.6 0.3 1.2 1 0 0 1 1 1 1 Interferon alpha/beta domain PI3_PI4_kinase PF00454.25 001099276.2_32929001_3 - 3.8e-57 193.8 0.4 8.4e-57 192.7 0.4 1.6 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.18 001099276.2_32929001_3 - 9e-38 129.4 2.4 1.5e-37 128.6 2.4 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.22 001099276.2_32929001_3 - 1.8e-30 105.6 0.0 3.1e-30 104.9 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.16 001099276.2_32929001_3 - 9.3e-28 96.4 0.1 1.9e-27 95.4 0.1 1.5 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain PX PF00787.22 001099276.2_32929001_3 - 8.2e-18 64.3 0.2 1.9e-17 63.2 0.2 1.7 1 0 0 1 1 1 1 PX domain C2 PF00168.28 001099276.2_32929001_3 - 3.4e-17 62.5 0.0 6.4e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 C2 domain DUF4135 PF13575.4 001099276.2_32929001_3 - 0.0083 15.4 0.0 0.013 14.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) HEAT_2 PF13646.4 001099276.2_32929001_3 - 0.069 13.4 0.1 0.41 10.9 0.0 2.3 2 0 0 2 2 2 0 HEAT repeats TGF_beta PF00019.18 008110.2_32924001_1 - 4.9e-26 91.5 0.2 1.2e-25 90.3 0.2 1.7 1 0 0 1 1 1 1 Transforming growth factor beta like domain COX7a PF02238.13 009944.3_32921001_1 - 5.3e-09 36.2 0.0 8.6e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII PL48 PF15903.3 001346031.1_26229001_2 - 5.2e-172 571.4 0.2 7.4e-172 570.9 0.2 1.2 1 0 0 1 1 1 1 Filopodia upregulated, FAM65 HEAT_2 PF13646.4 001346031.1_26229001_2 - 0.003 17.8 1.9 0.075 13.3 1.0 2.6 1 1 1 2 2 2 1 HEAT repeats Glu-tRNAGln PF02686.13 001346031.1_26229001_2 - 0.0075 16.4 0.2 0.68 10.1 0.1 2.6 2 0 0 2 2 2 1 Glu-tRNAGln amidotransferase C subunit HR1 PF02185.14 001346031.1_26229001_2 - 0.14 12.1 2.2 0.18 11.8 0.1 2.4 2 0 0 2 2 2 0 Hr1 repeat Sema PF01403.17 011352.2_32927001_2 - 1.2e-83 281.2 0.0 1.9e-83 280.5 0.0 1.3 1 0 0 1 1 1 1 Sema domain Ig_2 PF13895.4 011352.2_32927001_2 - 2.2e-06 27.8 0.2 5e-06 26.6 0.2 1.6 1 0 0 1 1 1 1 Immunoglobulin domain PSI PF01437.23 011352.2_32927001_2 - 1.7e-05 25.1 3.4 1.7e-05 25.1 3.4 2.1 2 0 0 2 2 2 1 Plexin repeat Ig_3 PF13927.4 011352.2_32927001_2 - 0.00042 20.7 0.1 0.0011 19.5 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain GCV_T_C PF08669.9 001244830.1_49825001_1 - 2.4e-06 27.5 0.0 4.6e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain GCV_T PF01571.19 001244830.1_49825001_1 - 0.0019 17.5 0.0 0.003 16.8 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain zf-LITAF-like PF10601.7 027907.1_32929120_1 - 2.8 8.1 11.1 3.2 7.9 0.6 2.9 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain Prion PF00377.16 001082021.1_37922001_1 - 3.4e-39 133.2 1.8 4.3e-39 132.9 1.8 1.1 1 0 0 1 1 1 1 Prion/Doppel alpha-helical domain Prion_bPrPp PF11587.6 001082021.1_37922001_1 - 6e-17 61.0 1.3 1.2e-16 60.1 1.3 1.5 1 0 0 1 1 1 1 Major prion protein bPrPp - N terminal eIF-3c_N PF05470.10 001199142.1_26227001_2 - 2.8e-273 907.6 35.2 1.6e-271 901.8 35.2 2.1 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.25 001199142.1_26227001_2 - 6.1e-17 61.9 0.1 1.8e-16 60.4 0.1 1.9 1 0 0 1 1 1 1 PCI domain LAM_C PF12544.6 001199142.1_26227001_2 - 3.3 7.8 8.8 0.28 11.3 2.9 2.2 1 1 1 2 2 2 0 Lysine-2,3-aminomutase DUF4674 PF15719.3 001199142.1_26227001_2 - 4.1 7.2 8.7 11 5.8 8.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4674) Heme_oxygenase PF01126.18 001004027.1_49824001_3 - 1.8e-79 266.2 3.5 2.2e-79 265.9 3.5 1.1 1 0 0 1 1 1 1 Heme oxygenase LTV PF04180.12 001004027.1_49824001_3 - 0.73 9.4 4.0 3.4 7.2 0.4 2.0 2 0 0 2 2 2 0 Low temperature viability protein FAD_binding_1 PF00667.18 008898.2_32926001_2 - 2e-83 279.2 0.0 2.9e-83 278.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.23 008898.2_32926001_2 - 4.8e-39 133.7 0.2 2e-38 131.7 0.3 2.0 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.19 008898.2_32926001_2 - 1e-17 64.6 0.0 3.2e-17 63.0 0.0 1.9 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DUF4761 PF15958.3 008898.2_32926001_2 - 0.14 12.1 0.1 12 6.0 0.0 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4761) DUF29 PF01724.14 008898.2_32926001_2 - 0.16 12.1 0.0 5.9 7.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF29 Thioredoxin_7 PF13899.4 006408.3_26222001_2 - 1.2e-23 82.9 0.0 2e-23 82.2 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.4 006408.3_26222001_2 - 0.04 14.2 0.1 0.16 12.3 0.1 1.9 1 1 0 1 1 1 0 Thioredoxin-like domain Ion_trans PF00520.29 001145749.1_49826001_1 - 1.6e-32 112.5 18.1 2.8e-32 111.7 18.1 1.4 1 0 0 1 1 1 1 Ion transport protein TRP_2 PF08344.9 001145749.1_49826001_1 - 1.2e-26 92.5 2.0 1.6e-26 92.1 0.6 2.0 2 0 0 2 2 2 1 Transient receptor ion channel II PKD_channel PF08016.10 001145749.1_49826001_1 - 1.1e-12 47.3 17.3 3.8e-12 45.5 17.3 1.8 1 1 0 1 1 1 1 Polycystin cation channel Ank_2 PF12796.5 001145749.1_49826001_1 - 2.3e-10 40.8 0.2 3.7e-07 30.5 0.2 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.4 001145749.1_49826001_1 - 2.3e-07 30.9 0.3 0.12 12.6 0.0 4.3 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.4 001145749.1_49826001_1 - 3.8e-06 27.2 0.2 0.0023 18.4 0.0 3.3 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 001145749.1_49826001_1 - 9.8e-06 25.4 3.5 1.1 9.9 0.0 5.2 5 0 0 5 5 4 1 Ankyrin repeat Ank PF00023.28 001145749.1_49826001_1 - 0.00026 21.2 0.6 2 8.9 0.0 3.7 3 0 0 3 3 3 1 Ankyrin repeat PBC PF03792.11 001145749.1_49826001_1 - 0.021 14.5 0.0 0.043 13.5 0.0 1.5 1 0 0 1 1 1 0 PBC domain DUF4252 PF14060.4 001145749.1_49826001_1 - 0.19 11.5 2.7 10 5.8 0.1 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4252) ING PF12998.5 001145749.1_49826001_1 - 0.28 11.7 6.1 4.7 7.7 2.2 2.7 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Tetraspannin PF00335.18 001145749.1_49826001_1 - 6 6.5 11.4 1 9.0 0.5 3.3 3 0 0 3 3 3 0 Tetraspanin family Steroid_dh PF02544.14 001324323.1_26226001_2 - 5.7e-68 227.5 1.3 9.8e-68 226.7 1.3 1.4 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.10 001324323.1_26226001_2 - 1.5e-07 31.0 0.2 2.6e-07 30.3 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) zf-C2H2 PF00096.24 001105078.3_26229001_2 - 9.8e-48 157.9 77.7 7.8e-07 29.1 1.4 11.0 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001105078.3_26229001_2 - 3e-32 109.5 70.4 5.2e-08 32.9 1.2 11.8 11 0 0 11 11 11 6 Zinc-finger double domain zf-C2H2_4 PF13894.4 001105078.3_26229001_2 - 2.8e-30 102.2 75.9 0.0011 19.5 0.7 11.5 11 0 0 11 11 10 10 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001105078.3_26229001_2 - 2.6e-11 43.1 63.1 0.00019 21.2 0.2 10.1 10 0 0 10 10 10 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001105078.3_26229001_2 - 2.3e-08 34.0 59.2 0.0033 17.6 0.8 11.4 12 0 0 12 12 11 6 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.4 001105078.3_26229001_2 - 6.4e-05 22.5 2.4 6.4e-05 22.5 2.4 8.6 9 1 0 9 9 8 5 C2H2-type zinc-finger domain zf-BED PF02892.13 001105078.3_26229001_2 - 0.001 18.9 0.7 0.001 18.9 0.7 8.2 4 3 5 9 9 9 3 BED zinc finger Zn-ribbon_8 PF09723.8 001105078.3_26229001_2 - 0.013 15.5 1.6 0.013 15.5 1.6 7.8 7 1 0 7 7 7 0 Zinc ribbon domain zf-C2H2_8 PF15909.3 001105078.3_26229001_2 - 0.021 15.0 40.2 0.16 12.2 7.5 5.6 2 1 3 5 5 5 0 C2H2-type zinc ribbon zf-C2H2_11 PF16622.3 001105078.3_26229001_2 - 0.023 14.3 53.4 0.075 12.7 0.8 8.5 10 0 0 10 10 9 0 zinc-finger C2H2-type GAGA PF09237.9 001105078.3_26229001_2 - 0.072 12.8 19.1 3.7 7.3 0.1 5.5 3 1 2 5 5 5 0 GAGA factor PyrI_C PF02748.13 001105078.3_26229001_2 - 0.5 10.2 0.0 0.5 10.2 0.0 7.0 6 1 1 7 7 7 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-met PF12874.5 001105078.3_26229001_2 - 3 8.2 53.8 0.53 10.6 0.3 9.9 10 0 0 10 10 10 0 Zinc-finger of C2H2 type BolA PF01722.16 001105078.3_26229001_2 - 7.4 6.8 8.8 38 4.5 0.1 4.6 3 3 2 5 5 5 0 BolA-like protein Ribosomal_L31 PF01197.16 001105078.3_26229001_2 - 7.5 6.7 8.2 8.3 6.6 1.1 3.5 2 1 1 3 3 3 0 Ribosomal protein L31 Gal-bind_lectin PF00337.20 031832.1_45722001_2 - 1e-37 128.5 0.1 1.2e-37 128.2 0.1 1.1 1 0 0 1 1 1 1 Galactoside-binding lectin 7tm_1 PF00001.19 001193306.1_26223001_3 - 2.2e-35 122.1 18.4 6.8e-35 120.5 18.4 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Phage_holin_2_1 PF04971.10 001193306.1_26223001_3 - 0.035 13.9 1.0 0.082 12.8 1.0 1.6 1 0 0 1 1 1 0 Bacteriophage P21 holin S 7TM_GPCR_Srx PF10328.7 001193306.1_26223001_3 - 0.066 12.4 9.5 0.1 11.7 9.5 1.4 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx U-box PF04564.13 001025625.2_45723001_2 - 1.1e-30 105.5 0.0 1.6e-30 104.9 0.0 1.3 1 0 0 1 1 1 1 U-box domain TPR_1 PF00515.26 001025625.2_45723001_2 - 1.1e-17 62.8 5.9 5.2e-09 35.4 0.3 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.15 001025625.2_45723001_2 - 1.2e-13 49.9 8.5 3e-05 23.7 0.3 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat ANAPC3 PF12895.5 001025625.2_45723001_2 - 4.9e-12 45.7 1.7 9.5e-12 44.8 1.7 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.4 001025625.2_45723001_2 - 9.1e-11 42.1 1.7 2.8e-06 27.8 0.5 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.4 001025625.2_45723001_2 - 2.4e-09 36.5 4.1 0.0008 19.3 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.4 001025625.2_45723001_2 - 4.5e-09 36.4 10.6 1.4e-07 31.6 3.5 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.4 001025625.2_45723001_2 - 5.8e-08 32.1 1.9 0.047 13.2 0.1 3.3 1 1 2 3 3 3 3 TPR repeat TPR_17 PF13431.4 001025625.2_45723001_2 - 1.2e-06 28.3 0.4 0.0015 18.7 0.2 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.4 001025625.2_45723001_2 - 1.4e-05 25.4 2.5 1.9e-05 25.0 1.3 1.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.4 001025625.2_45723001_2 - 0.0011 19.4 4.4 1.6 9.4 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.4 001025625.2_45723001_2 - 0.0013 18.8 4.0 0.01 15.9 0.6 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.4 001025625.2_45723001_2 - 0.0014 19.1 6.4 0.02 15.5 0.1 3.8 3 1 1 4 4 3 1 Tetratricopeptide repeat TPR_7 PF13176.4 001025625.2_45723001_2 - 0.0016 18.2 3.5 12 6.1 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.4 001025625.2_45723001_2 - 0.012 15.4 5.3 0.091 12.6 0.2 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-NOSIP PF15906.3 001025625.2_45723001_2 - 0.11 12.6 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein SHNi-TPR PF10516.7 001025625.2_45723001_2 - 0.13 11.6 2.7 5 6.5 0.2 2.6 2 0 0 2 2 2 0 SHNi-TPR TPR_20 PF14561.4 001025625.2_45723001_2 - 6.6 7.0 6.5 8.5 6.7 0.9 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat SAP PF02037.25 001146312.2_26229001_3 - 8.9e-10 38.0 0.1 1.9e-09 36.9 0.1 1.6 1 0 0 1 1 1 1 SAP domain RPEL PF02755.13 001146312.2_26229001_3 - 9.6e-10 37.7 4.5 2.1e-06 27.1 0.3 3.5 3 0 0 3 3 3 2 RPEL repeat IncA PF04156.12 001146312.2_26229001_3 - 0.23 11.1 6.4 0.11 12.1 0.1 2.5 2 0 0 2 2 2 0 IncA protein p450 PF00067.20 031839.3_45724001_1 - 3.6e-156 520.4 0.1 4.2e-156 520.2 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 CDC50 PF03381.13 031839.3_45724001_1 - 0.026 13.9 0.1 0.038 13.4 0.1 1.2 1 0 0 1 1 1 0 LEM3 (ligand-effect modulator 3) family / CDC50 family UCH PF00443.27 003363.3_26229001_2 - 8.3e-83 277.7 0.1 1.1e-82 277.2 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_3 PF14836.4 003363.3_26229001_2 - 3.2e-31 106.9 0.1 6.7e-31 105.9 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-like domain DUSP PF06337.10 003363.3_26229001_2 - 5.3e-23 81.3 1.0 1.2e-22 80.2 1.0 1.7 1 0 0 1 1 1 1 DUSP domain UCH_1 PF13423.4 003363.3_26229001_2 - 1.9e-20 73.6 0.0 1.1e-12 48.1 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.4 003363.3_26229001_2 - 1.5e-05 24.7 0.0 0.00025 20.7 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin-specific protease C-terminal USP7_ICP0_bdg PF12436.6 003363.3_26229001_2 - 0.00026 20.4 0.3 0.00059 19.2 0.0 1.7 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 CW_binding_1 PF01473.18 003363.3_26229001_2 - 0.28 11.4 4.3 1.3 9.4 4.3 2.2 1 0 0 1 1 1 0 Putative cell wall binding repeat Thioredoxin PF00085.18 214313.2_49821001_2 - 1.6e-32 111.4 1.3 1.9e-32 111.2 1.3 1.0 1 0 0 1 1 1 1 Thioredoxin DIM1 PF02966.14 214313.2_49821001_2 - 7.2e-06 25.7 0.1 8.5e-06 25.4 0.1 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin_8 PF13905.4 214313.2_49821001_2 - 1.7e-05 24.9 0.2 5e-05 23.4 0.2 1.7 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.4 214313.2_49821001_2 - 0.00017 21.9 0.2 0.0012 19.2 0.2 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.4 214313.2_49821001_2 - 0.00024 21.1 0.3 0.00036 20.5 0.3 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.4 214313.2_49821001_2 - 0.00039 20.1 0.0 0.00044 19.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.11 214313.2_49821001_2 - 0.0004 19.7 0.4 0.00044 19.6 0.4 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Glutaredoxin PF00462.22 214313.2_49821001_2 - 0.0034 17.4 0.7 0.0061 16.6 0.7 1.4 1 0 0 1 1 1 1 Glutaredoxin AhpC-TSA PF00578.19 214313.2_49821001_2 - 0.0049 16.7 0.3 0.0058 16.4 0.3 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.8 214313.2_49821001_2 - 0.05 13.2 0.1 0.053 13.1 0.1 1.2 1 0 0 1 1 1 0 Redoxin zf-H2C2_2 PF13465.4 031788.1_45727001_1 - 2.9e-30 103.2 68.8 2.9e-08 33.6 1.3 11.3 11 1 0 11 11 11 6 Zinc-finger double domain zf-H2C2_5 PF13909.4 031788.1_45727001_1 - 2.5e-23 81.3 71.4 7.4e-08 31.9 4.8 8.9 9 0 0 9 9 9 6 C2H2-type zinc-finger domain zf-C2H2 PF00096.24 031788.1_45727001_1 - 1.9e-13 49.9 82.5 0.00031 20.9 4.5 9.5 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 031788.1_45727001_1 - 1.7e-10 40.7 75.3 0.027 15.1 3.2 9.5 9 0 0 9 9 9 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 031788.1_45727001_1 - 0.0031 17.7 1.4 0.0031 17.7 1.4 8.1 8 0 0 8 8 8 4 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.5 031788.1_45727001_1 - 0.98 9.7 45.8 1.5 9.0 0.0 6.0 3 1 3 6 6 6 0 C2H2 type zinc-finger (2 copies) VGCC_alpha2 PF08473.9 001110848.1_45727001_1 - 3.8e-214 711.2 1.1 6.5e-214 710.4 1.1 1.4 1 0 0 1 1 1 1 Neuronal voltage-dependent calcium channel alpha 2acd VWA_N PF08399.9 001110848.1_45727001_1 - 8.3e-40 136.0 0.2 2.5e-39 134.4 0.1 1.9 2 0 0 2 2 2 1 VWA N-terminal VWA PF00092.26 001110848.1_45727001_1 - 2.9e-21 76.4 0.8 5.8e-21 75.4 0.8 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.4 001110848.1_45727001_1 - 1.6e-15 57.2 0.0 2.8e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain dCache_1 PF02743.16 001110848.1_45727001_1 - 1.4e-11 44.6 12.0 6.4e-10 39.1 0.2 4.1 3 1 0 3 3 3 2 Cache domain VWA_2 PF13519.4 001110848.1_45727001_1 - 1e-10 42.1 1.1 3.7e-10 40.3 0.4 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain Cache_3-Cache_2 PF17201.2 001110848.1_45727001_1 - 0.0017 17.5 0.0 0.0046 16.2 0.0 1.6 1 0 0 1 1 1 1 Cache 3/Cache 2 fusion domain IFN-gamma PF00714.15 001110848.1_45727001_1 - 0.056 13.1 0.5 0.14 11.8 0.5 1.6 1 0 0 1 1 1 0 Interferon gamma PDEase_I PF00233.17 031080.1_45727001_3 - 7.9e-77 258.1 0.5 1.1e-76 257.6 0.5 1.1 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase ATP_bind_1 PF03029.15 016301.3_26224001_1 - 4.3e-92 308.1 0.5 5e-92 307.8 0.5 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CLP1_P PF16575.3 016301.3_26224001_1 - 0.0021 17.8 0.0 0.0068 16.1 0.0 1.8 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_30 PF13604.4 016301.3_26224001_1 - 0.0058 16.2 0.0 0.0099 15.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.5 016301.3_26224001_1 - 0.014 14.2 0.0 0.023 13.5 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_31 PF13614.4 016301.3_26224001_1 - 0.017 14.9 0.1 3.6 7.3 0.0 2.6 3 0 0 3 3 3 0 AAA domain CbiA PF01656.21 016301.3_26224001_1 - 0.024 14.6 0.0 0.037 14.0 0.0 1.3 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_17 PF13207.4 016301.3_26224001_1 - 0.046 14.0 0.1 0.19 12.0 0.0 2.0 2 1 1 3 3 3 0 AAA domain AAA_19 PF13245.4 016301.3_26224001_1 - 0.053 13.7 0.0 0.62 10.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.4 016301.3_26224001_1 - 0.058 13.5 0.0 0.18 12.0 0.0 1.8 2 0 0 2 2 1 0 AAA domain FtsK_SpoIIIE PF01580.16 016301.3_26224001_1 - 0.069 12.3 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF87 PF01935.15 016301.3_26224001_1 - 0.078 12.9 0.0 0.18 11.7 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function DUF87 ArgK PF03308.14 016301.3_26224001_1 - 0.11 11.4 0.0 0.17 10.7 0.0 1.2 1 0 0 1 1 1 0 ArgK protein SRP54 PF00448.20 016301.3_26224001_1 - 0.11 11.9 0.0 0.25 10.8 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_29 PF13555.4 016301.3_26224001_1 - 0.12 11.9 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSE PF00437.18 016301.3_26224001_1 - 0.17 10.8 0.0 0.25 10.2 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein FAD_binding_1 PF00667.18 031576.1_45725001_2 - 2.9e-83 278.7 0.0 4.1e-83 278.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.23 031576.1_45725001_2 - 4e-39 133.9 0.2 1.9e-38 131.8 0.3 2.1 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.19 031576.1_45725001_2 - 5.1e-18 65.6 0.0 1.5e-17 64.1 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DUF29 PF01724.14 031576.1_45725001_2 - 0.15 12.2 0.0 5.6 7.1 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF29 DUF4761 PF15958.3 031576.1_45725001_2 - 0.16 12.0 0.1 13 5.9 0.0 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4761) HARP PF07443.11 001127207.1_26227001_1 - 2.8e-53 177.2 0.4 1.4e-25 88.5 0.0 2.5 2 0 0 2 2 2 2 HepA-related protein (HARP) SNF2_N PF00176.21 001127207.1_26227001_1 - 7.8e-25 87.2 0.0 1.5e-24 86.3 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.29 001127207.1_26227001_1 - 5.6e-15 55.5 0.0 2e-14 53.8 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.13 001127207.1_26227001_1 - 7.4e-05 22.7 0.0 0.0029 17.5 0.0 2.8 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.3 001127207.1_26227001_1 - 0.00053 19.1 0.1 0.0011 18.2 0.1 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Flavi_DEAD PF07652.12 001127207.1_26227001_1 - 0.0051 16.7 0.5 0.31 10.9 0.0 3.0 2 1 1 3 3 3 1 Flavivirus DEAD domain Transposase_24 PF03004.12 001127207.1_26227001_1 - 2.8 7.9 6.8 17 5.4 0.1 3.1 3 0 0 3 3 3 0 Plant transposase (Ptta/En/Spm family) IL5 PF02025.13 001009845.2_22422001_3 - 2.3e-60 201.6 0.1 3.7e-60 200.9 0.1 1.3 1 0 0 1 1 1 1 Interleukin 5 CEP209_CC5 PF16574.3 001101658.1_22429001_1 - 1.8e-52 176.7 24.4 1.8e-52 176.7 24.4 21.3 10 5 14 25 25 25 3 Coiled-coil region of centrosome protein CE290 Motilin_ghrelin PF04644.10 001009278.1_22422001_2 - 5.5e-17 61.2 1.3 8.9e-17 60.5 1.3 1.4 1 0 0 1 1 1 1 Motilin/ghrelin Motilin_assoc PF04643.10 001009278.1_22422001_2 - 7.2e-11 41.6 0.0 1.1e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Motilin/ghrelin-associated peptide DUF3807 PF12720.5 001009278.1_22422001_2 - 0.046 13.9 0.2 0.062 13.5 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) PDEase_I PF00233.17 001204776.2_22426001_1 - 1.9e-77 260.1 1.6 1.9e-77 260.1 1.6 2.4 2 1 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.24 001204776.2_22426001_1 - 1.2e-32 113.0 0.0 3.5e-15 56.6 0.0 2.6 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.4 001204776.2_22426001_1 - 1.8e-08 34.6 0.0 0.0003 21.0 0.0 2.5 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.4 001204776.2_22426001_1 - 0.0088 16.2 0.0 0.78 9.9 0.0 3.0 2 1 0 2 2 2 1 GAF domain HD PF01966.20 001204776.2_22426001_1 - 0.081 13.0 0.1 0.28 11.3 0.1 1.9 1 0 0 1 1 1 0 HD domain zf-C2H2 PF00096.24 001112709.1_22426001_2 - 2.7e-26 90.4 42.9 2.4e-05 24.4 1.0 7.1 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.4 001112709.1_22426001_2 - 4.4e-26 90.0 40.9 4.7e-06 26.7 2.0 7.4 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2_4 PF13894.4 001112709.1_22426001_2 - 2.3e-18 65.2 46.7 0.0021 18.6 0.8 7.1 7 0 0 7 7 6 6 C2H2-type zinc finger zf-C2H2_6 PF13912.4 001112709.1_22426001_2 - 2.9e-11 42.9 36.3 0.0058 16.4 1.6 6.6 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.6 001112709.1_22426001_2 - 1.4e-10 41.1 23.0 0.034 14.3 0.0 7.3 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.5 001112709.1_22426001_2 - 4.8e-09 36.2 18.0 0.0071 16.6 0.5 5.6 5 0 0 5 5 5 3 Zinc-finger of C2H2 type Ta0938 PF11494.6 001112709.1_22426001_2 - 0.00061 19.9 0.8 0.11 12.7 0.0 2.6 2 1 0 2 2 2 1 Ta0938 zf-Di19 PF05605.10 001112709.1_22426001_2 - 0.24 11.6 21.0 0.81 9.9 3.4 4.4 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.13 001112709.1_22426001_2 - 0.34 10.9 32.5 0.66 9.9 5.3 5.4 4 1 2 6 6 6 0 BED zinc finger zf-CHCC PF10276.7 001112709.1_22426001_2 - 0.38 10.7 9.5 1.4 8.9 0.3 4.0 4 0 0 4 4 4 0 Zinc-finger domain zf-C2HC_2 PF13913.4 001112709.1_22426001_2 - 0.59 10.0 20.1 4.2 7.2 1.0 5.4 5 0 0 5 5 5 0 zinc-finger of a C2HC-type FYVE PF01363.19 001112709.1_22426001_2 - 0.62 10.1 24.6 2.6 8.1 8.9 3.4 1 1 1 3 3 3 0 FYVE zinc finger Zn-ribbon_8 PF09723.8 001112709.1_22426001_2 - 0.78 9.8 20.6 2.8 8.0 2.4 5.0 3 2 2 5 5 5 0 Zinc ribbon domain BolA PF01722.16 001112709.1_22426001_2 - 2.3 8.4 6.5 3.7 7.8 0.5 3.1 2 1 0 2 2 2 0 BolA-like protein GAGA PF09237.9 001112709.1_22426001_2 - 3.5 7.4 6.2 23 4.8 0.1 3.7 2 2 2 4 4 4 0 GAGA factor zinc_ribbon_15 PF17032.3 001112709.1_22426001_2 - 5.8 7.6 13.3 62 4.3 3.3 3.2 1 1 1 2 2 2 0 zinc-ribbon family APOBEC_N PF08210.9 001112710.3_22422001_1 - 1.9e-38 132.1 0.8 2.4e-38 131.7 0.8 1.1 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC_C PF05240.12 001112710.3_22422001_1 - 5.8e-33 112.5 0.0 9e-33 111.9 0.0 1.3 1 0 0 1 1 1 1 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.21 001112710.3_22422001_1 - 3.6e-05 23.4 0.1 5.1e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.4 001112710.3_22422001_1 - 0.044 13.4 0.1 0.063 12.9 0.1 1.2 1 0 0 1 1 1 0 MafB19-like deaminase FANCL_C PF11793.6 001112710.3_22422001_1 - 0.16 12.0 1.9 0.3 11.2 1.9 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain DUF929 PF06053.9 001112710.3_22422001_1 - 0.18 10.9 0.0 0.24 10.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF929) Bcl-2 PF00452.17 001009282.2_22422001_1 - 1.4e-27 96.0 0.1 2.5e-27 95.3 0.1 1.4 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family CF222 PF15661.3 001009282.2_22422001_1 - 0.032 13.0 0.0 0.035 12.8 0.0 1.0 1 0 0 1 1 1 0 C6orf222, uncharacterised family TNFR_c6 PF00020.16 001009200.1_22423001_1 - 5.8e-17 61.7 42.1 8.3e-08 32.4 13.0 3.7 4 0 0 4 4 4 3 TNFR/NGFR cysteine-rich region START PF01852.17 001246196.1_22422001_3 - 4.2e-52 176.5 0.0 5.3e-52 176.1 0.0 1.1 1 0 0 1 1 1 1 START domain Polyketide_cyc PF03364.18 001246196.1_22422001_3 - 0.024 14.7 0.0 0.25 11.4 0.0 2.1 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport WD40 PF00400.30 001114340.1_22423001_2 - 8.3e-63 206.7 17.1 1.2e-08 35.3 0.3 7.8 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 001114340.1_22423001_2 - 6.8e-16 58.2 3.1 0.052 13.7 0.0 5.9 2 2 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.6 001114340.1_22423001_2 - 2.2e-12 46.2 11.2 0.0097 14.4 0.0 6.4 2 2 4 7 7 7 4 Nucleoporin Nup120/160 LisH PF08513.9 001114340.1_22423001_2 - 7.9e-09 35.1 0.4 2e-08 33.8 0.4 1.7 1 0 0 1 1 1 1 LisH eIF2A PF08662.9 001114340.1_22423001_2 - 3.6e-05 23.6 2.1 0.075 12.8 0.1 2.7 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.9 001114340.1_22423001_2 - 0.00016 20.5 2.3 0.4 9.2 0.0 4.1 1 1 3 5 5 5 1 Nup133 N terminal like Pox_A_type_inc PF04508.10 001114340.1_22423001_2 - 0.0019 17.9 0.1 0.0041 16.8 0.1 1.6 1 0 0 1 1 1 1 Viral A-type inclusion protein repeat LisH_2 PF16045.3 001114340.1_22423001_2 - 0.018 14.0 0.0 0.032 13.2 0.0 1.4 1 0 0 1 1 1 0 LisH p450 PF00067.20 001048010.1_22423001_1 - 2.5e-146 487.9 0.0 2.9e-146 487.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.20 001246278.2_22424001_3 - 2e-130 435.5 0.1 2.3e-130 435.3 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 BST2 PF16716.3 001243085.1_22422001_1 - 1.6e-36 124.6 8.0 2.2e-36 124.2 8.0 1.2 1 0 0 1 1 1 1 Bone marrow stromal antigen 2 MscS_porin PF12795.5 001243085.1_22422001_1 - 0.00018 21.0 4.6 0.00052 19.5 0.6 2.0 1 1 1 2 2 2 1 Mechanosensitive ion channel porin domain GrpE PF01025.17 001243085.1_22422001_1 - 0.0096 15.5 0.7 0.013 15.0 0.7 1.2 1 0 0 1 1 1 1 GrpE TolA_bind_tri PF16331.3 001243085.1_22422001_1 - 0.038 13.9 0.7 0.071 13.1 0.6 1.5 1 1 0 1 1 1 0 TolA binding protein trimerisation GAS PF13851.4 001243085.1_22422001_1 - 0.045 13.0 6.7 0.11 11.7 5.8 1.8 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding HIP1_clath_bdg PF16515.3 001243085.1_22422001_1 - 0.23 11.9 6.2 0.49 10.9 6.1 1.6 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF972 PF06156.11 001243085.1_22422001_1 - 0.25 11.8 1.8 0.37 11.3 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF972) V-set PF07686.15 001009296.1_22422001_1 - 3.5e-11 43.1 0.0 5.2e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001009296.1_22422001_1 - 0.00015 22.2 0.1 0.00095 19.6 0.1 2.2 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001009296.1_22422001_1 - 0.0094 16.0 0.0 0.036 14.1 0.0 1.9 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001009296.1_22422001_1 - 0.011 15.7 0.0 0.041 13.8 0.0 1.8 1 1 0 1 1 1 0 Immunoglobulin I-set domain Ig_2 PF13895.4 001009296.1_22422001_1 - 0.022 14.9 0.0 0.07 13.3 0.0 1.8 1 1 0 1 1 1 0 Immunoglobulin domain V-set PF07686.15 001145510.1_22423001_1 - 4.1e-16 58.9 0.0 6.1e-16 58.4 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001145510.1_22423001_1 - 3.8e-05 24.1 0.0 0.00011 22.6 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 001145510.1_22423001_1 - 0.002 18.0 0.0 0.0037 17.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 001145510.1_22423001_1 - 0.0048 17.1 0.0 0.02 15.1 0.0 1.9 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001145510.1_22423001_1 - 0.0069 16.4 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain YSIRK_signal PF04650.15 001145510.1_22423001_1 - 5.8 6.7 6.2 8.9 6.2 6.2 1.3 1 0 0 1 1 1 0 YSIRK type signal peptide TGF_beta PF00019.18 001009856.1_22423001_1 - 6.1e-31 107.3 1.4 1.3e-30 106.2 1.4 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.16 001009856.1_22423001_1 - 9.1e-09 35.3 0.2 4.8e-08 32.9 0.2 1.9 1 1 0 1 1 1 1 TGF-beta propeptide Ferritin PF00210.22 001048150.1_22422001_1 - 6.7e-29 100.5 0.7 8.1e-29 100.3 0.7 1.1 1 0 0 1 1 1 1 Ferritin-like domain ANAPC4 PF12896.5 001048150.1_22422001_1 - 0.028 13.8 0.1 0.038 13.3 0.1 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 4 ETF_QO PF05187.11 001290236.1_22425001_2 - 8.3e-49 163.9 0.0 1.5e-48 163.1 0.0 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Thi4 PF01946.15 001290236.1_22425001_2 - 2.3e-08 33.4 0.0 2.1e-06 27.0 0.0 2.1 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.22 001290236.1_22425001_2 - 3.1e-08 33.0 0.7 8.5e-05 21.7 1.0 2.1 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.22 001290236.1_22425001_2 - 1.1e-07 31.6 0.3 8.2e-05 22.3 0.4 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.4 001290236.1_22425001_2 - 4.3e-07 29.9 0.0 2.4e-06 27.6 0.1 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.10 001290236.1_22425001_2 - 1.6e-05 24.0 0.1 2.3e-05 23.5 0.1 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.12 001290236.1_22425001_2 - 1.9e-05 23.9 0.0 2.6e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.4 001290236.1_22425001_2 - 0.00016 21.6 0.1 0.00037 20.4 0.1 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.17 001290236.1_22425001_2 - 0.0002 20.6 0.1 0.00044 19.5 0.0 1.5 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.12 001290236.1_22425001_2 - 0.00048 18.8 0.5 0.00068 18.3 0.5 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.25 001290236.1_22425001_2 - 0.001 19.5 0.1 1.8 9.1 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.4 001290236.1_22425001_2 - 0.0048 16.1 0.1 0.0072 15.5 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.12 001290236.1_22425001_2 - 0.0086 14.8 0.3 0.026 13.2 0.1 1.8 2 0 0 2 2 2 1 Tryptophan halogenase Fer4_7 PF12838.5 001290236.1_22425001_2 - 0.016 15.7 0.4 0.035 14.6 0.4 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain FAD_oxidored PF12831.5 001290236.1_22425001_2 - 0.017 14.4 0.1 0.025 13.8 0.1 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.19 001290236.1_22425001_2 - 0.096 11.8 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.20 001290236.1_22425001_2 - 0.099 11.6 0.3 0.15 11.0 0.3 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A K_oxygenase PF13434.4 001290236.1_22425001_2 - 0.13 11.2 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Neuromodulin PF06614.9 001009303.1_22422001_1 - 4.6e-78 261.2 62.1 4.6e-78 261.2 62.1 1.8 2 0 0 2 2 2 1 Neuromodulin Neuromodulin_N PF10580.7 001009303.1_22422001_1 - 2.1e-18 65.6 6.2 2.1e-18 65.6 6.2 3.1 3 0 0 3 3 3 1 Gap junction protein N-terminal region IQ PF00612.25 001009303.1_22422001_1 - 1.7e-06 27.2 0.4 3.1e-06 26.4 0.4 1.5 1 0 0 1 1 1 1 IQ calmodulin-binding motif Ald_Xan_dh_C2 PF02738.16 001009217.1_22429001_1 - 2.1e-208 693.1 0.0 2.9e-208 692.6 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.19 001009217.1_22429001_1 - 2.5e-42 144.4 0.0 4.7e-42 143.5 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.20 001009217.1_22429001_1 - 9e-35 119.2 0.1 1.7e-34 118.3 0.1 1.5 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.18 001009217.1_22429001_1 - 3.6e-31 106.8 0.1 9.2e-31 105.5 0.1 1.8 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.15 001009217.1_22429001_1 - 9.9e-27 93.0 0.0 6.4e-26 90.4 0.0 2.2 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.25 001009217.1_22429001_1 - 1.9e-09 37.2 1.6 7.2e-09 35.4 0.1 2.5 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Glyco_transf_6 PF03414.11 001009308.1_22423001_1 - 2.7e-157 522.4 3.7 3.2e-157 522.2 3.7 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 6 SAA PF00277.16 001040198.1_22421001_1 - 7e-51 170.9 5.5 8e-51 170.7 5.5 1.0 1 0 0 1 1 1 1 Serum amyloid A protein BRCA-2_helical PF09169.8 001009858.1_22429001_1 - 1.1e-93 312.0 0.0 2.8e-93 310.7 0.0 1.8 1 0 0 1 1 1 1 BRCA2, helical BRCA2 PF00634.16 001009858.1_22429001_1 - 5.9e-83 271.9 24.7 1.8e-12 46.4 0.1 7.8 7 0 0 7 7 7 7 BRCA2 repeat BRCA-2_OB3 PF09104.8 001009858.1_22429001_1 - 1.3e-56 190.0 0.2 6.4e-56 187.7 0.0 2.5 2 0 0 2 2 2 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 BRCA-2_OB1 PF09103.8 001009858.1_22429001_1 - 1.1e-40 138.2 0.0 3.4e-39 133.4 0.0 3.1 2 0 0 2 2 2 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 Tower PF09121.8 001009858.1_22429001_1 - 3e-22 78.4 2.9 9.6e-22 76.8 2.9 2.0 1 0 0 1 1 1 1 Tower RhoGAP PF00620.25 001193650.1_22425001_2 - 2.8e-50 169.9 0.0 4.4e-50 169.3 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.20 001193650.1_22425001_2 - 1.3e-15 56.8 7.5 1.3e-15 56.8 7.5 1.9 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_2 PF13831.4 001193650.1_22425001_2 - 0.11 11.9 1.6 0.31 10.5 1.6 1.7 1 0 0 1 1 1 0 PHD-finger FYVE_2 PF02318.14 001193650.1_22425001_2 - 0.28 11.3 3.1 0.54 10.4 3.1 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger zf-RING-like PF08746.9 001193650.1_22425001_2 - 0.47 10.7 5.1 1.1 9.5 5.1 1.6 1 0 0 1 1 1 0 RING-like domain Ribosomal_L22 PF00237.17 001128842.1_22422001_1 - 1.7e-42 143.9 0.1 3e-42 143.1 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e CD34_antigen PF06365.10 001009318.1_22423001_2 - 3.2e-71 239.1 0.0 4.9e-71 238.5 0.0 1.3 1 0 0 1 1 1 1 CD34/Podocalyxin family Trefoil PF00088.16 001130388.1_22421001_2 - 7.6e-28 96.0 23.3 7.9e-15 54.3 7.4 2.3 2 0 0 2 2 2 2 Trefoil (P-type) domain TEX29 PF15839.3 001130388.1_22421001_2 - 3.1 8.3 8.9 4.3 7.9 1.0 2.3 2 0 0 2 2 2 0 Testis-expressed sequence 29 protein Lipase PF00151.17 001042567.1_22424001_1 - 2.4e-128 428.1 0.0 3.3e-128 427.6 0.0 1.1 1 0 0 1 1 1 1 Lipase PLAT PF01477.21 001042567.1_22424001_1 - 6.1e-27 94.4 1.2 1.1e-26 93.6 1.2 1.4 1 0 0 1 1 1 1 PLAT/LH2 domain Abhydrolase_1 PF00561.18 001042567.1_22424001_1 - 8.2e-05 22.2 0.0 0.00013 21.6 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 001042567.1_22424001_1 - 0.00015 22.3 0.3 0.00024 21.7 0.3 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family SIR2 PF02146.15 001290245.1_22424001_1 - 8.1e-54 182.1 0.0 1.1e-53 181.7 0.0 1.2 1 0 0 1 1 1 1 Sir2 family SIR2 PF02146.15 001290246.1_22429001_1 - 8.3e-62 208.1 0.0 2.5e-61 206.5 0.0 1.8 2 0 0 2 2 2 1 Sir2 family DUF592 PF04574.11 001290246.1_22429001_1 - 0.016 14.9 0.2 0.026 14.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.20 001290246.1_22429001_1 - 0.029 14.0 0.0 8.4 6.0 0.0 2.2 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain HECW_N PF16562.3 001043337.1_22422001_2 - 0.069 12.8 0.4 0.11 12.2 0.4 1.3 1 0 0 1 1 1 0 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 IL2 PF00715.15 001043337.1_22422001_3 - 1e-79 265.4 5.6 1.2e-79 265.1 5.6 1.1 1 0 0 1 1 1 1 Interleukin 2 Calc_CGRP_IAPP PF00214.17 001043338.1_22421001_1 - 3.6e-17 62.7 3.5 3.5e-15 56.3 0.3 2.1 1 1 1 2 2 2 2 Calcitonin / CGRP / IAPP family Pou PF00157.15 001173441.1_22423001_1 - 3.3e-38 129.4 0.8 7.2e-38 128.3 0.8 1.6 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox PF00046.27 001173441.1_22423001_1 - 8e-19 67.1 0.6 1.5e-18 66.2 0.6 1.5 1 0 0 1 1 1 1 Homeobox domain DUF521 PF04412.11 001173441.1_22423001_1 - 0.05 12.2 0.0 0.087 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF521) Homeobox_KN PF05920.9 001173441.1_22423001_1 - 0.17 11.7 0.5 0.46 10.3 0.0 2.0 2 0 0 2 2 2 0 Homeobox KN domain Ribosomal_S7e PF01251.16 001009832.1_22422001_3 - 8.8e-94 312.3 3.8 1e-93 312.1 3.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e Tubulin PF00091.23 001134989.1_22423001_1 - 1.8e-67 227.3 0.0 2.4e-67 226.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 001134989.1_22423001_1 - 1.8e-36 125.0 0.0 2.8e-36 124.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.7 001134989.1_22423001_1 - 4.8e-05 23.5 0.0 0.00015 21.9 0.0 1.8 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.4 001134989.1_22423001_1 - 0.065 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Tubulin domain Troponin PF00992.18 001009237.1_22422001_2 - 3.9e-45 153.3 6.6 7e-45 152.5 6.6 1.4 1 0 0 1 1 1 1 Troponin Troponin-I_N PF11636.6 001009237.1_22422001_2 - 2.8e-13 49.4 12.1 4.9e-13 48.6 12.1 1.4 1 0 0 1 1 1 1 Troponin I residues 1-32 Tup_N PF08581.8 001009237.1_22422001_2 - 0.0077 16.4 0.1 0.0077 16.4 0.1 2.1 3 0 0 3 3 3 1 Tup N-terminal Transposase_22 PF02994.12 001009237.1_22422001_2 - 0.017 13.8 3.2 0.013 14.3 1.4 1.6 1 1 0 1 1 1 0 L1 transposable element DUF919 PF06034.9 001009237.1_22422001_2 - 0.02 14.6 0.1 0.02 14.6 0.1 2.4 3 1 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF919) DUF3738 PF12543.6 001009237.1_22422001_2 - 0.091 12.8 0.9 0.34 10.9 0.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3738) Peptidase_C14 PF00656.20 001009338.1_22423001_3 - 1.2e-51 175.9 0.0 1.2e-51 175.9 0.0 1.4 2 0 0 2 2 2 1 Caspase domain EPO_TPO PF00758.16 001163656.1_22423001_1 - 1.9e-49 167.6 0.1 3e-49 167.0 0.1 1.4 1 0 0 1 1 1 1 Erythropoietin/thrombopoietin Bcl-2 PF00452.17 001009340.1_22423001_1 - 1.1e-31 109.2 0.1 1.9e-31 108.5 0.1 1.4 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family BH4 PF02180.15 001009340.1_22423001_1 - 8.8e-10 38.0 0.1 2.1e-09 36.8 0.1 1.6 1 0 0 1 1 1 1 Bcl-2 homology region 4 Bcl-2_3 PF15286.4 001009340.1_22423001_1 - 0.015 15.8 0.0 0.024 15.2 0.0 1.2 1 0 0 1 1 1 0 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like Ig_5 PF16681.3 001009862.1_22422001_1 - 2.2e-33 114.4 0.6 2.2e-33 114.4 0.6 1.6 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.3 001009862.1_22422001_1 - 4.7e-20 71.6 0.5 4.7e-20 71.6 0.5 1.7 2 0 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain ITAM PF02189.13 001009862.1_22422001_1 - 9.2e-05 22.5 0.7 0.00016 21.8 0.7 1.4 1 0 0 1 1 1 1 Immunoreceptor tyrosine-based activation motif Ig_2 PF13895.4 001009862.1_22422001_1 - 0.0001 22.4 0.1 0.00032 20.9 0.1 1.8 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 001009862.1_22422001_1 - 0.01 16.3 0.1 0.039 14.4 0.1 1.9 2 0 0 2 2 2 0 Immunoglobulin domain ig PF00047.23 001009862.1_22422001_1 - 0.088 12.9 0.4 0.53 10.4 0.4 2.2 1 1 0 1 1 1 0 Immunoglobulin domain P5-ATPase PF12409.6 001009862.1_22422001_1 - 0.12 12.4 0.1 0.22 11.5 0.1 1.4 1 0 0 1 1 1 0 P5-type ATPase cation transporter MOEP19 PF16005.3 001077245.1_22422001_2 - 2.2e-41 139.6 0.1 3e-41 139.2 0.1 1.2 1 0 0 1 1 1 1 KH-like RNA-binding domain Peptidase_M1 PF01433.18 001009252.2_22427001_2 - 8.5e-141 469.6 0.0 1.3e-140 469.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.6 001009252.2_22427001_2 - 5.4e-84 282.3 4.6 1e-83 281.4 4.6 1.5 1 0 0 1 1 1 1 ERAP1-like C-terminal domain HRG PF16954.3 001009252.2_22427001_2 - 0.11 12.8 0.1 0.31 11.4 0.1 1.7 1 0 0 1 1 1 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene Reprolysin_5 PF13688.4 001009252.2_22427001_2 - 1.2 9.1 3.9 63 3.5 0.0 3.6 3 0 0 3 3 3 0 Metallo-peptidase family M12 Cystatin PF00031.19 001009864.1_22421001_3 - 3e-23 81.8 0.3 4e-23 81.4 0.3 1.2 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.3 001009864.1_22421001_3 - 0.024 14.9 0.6 0.039 14.2 0.6 1.3 1 0 0 1 1 1 0 Aspartic acid proteinase inhibitor MHC_I PF00129.16 001305029.1_22423001_1 - 2.8e-94 313.6 0.9 4e-94 313.1 0.9 1.2 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C1-set PF07654.13 001305029.1_22423001_1 - 3.2e-17 62.7 0.0 5.8e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_C PF06623.9 001305029.1_22423001_1 - 9.5e-11 41.3 2.3 1.8e-10 40.4 2.3 1.5 1 0 0 1 1 1 1 MHC_I C-terminus C2-set_2 PF08205.10 001305029.1_22423001_1 - 1.6e-05 24.7 0.1 3.1e-05 23.9 0.1 1.4 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.4 001305029.1_22423001_1 - 8e-05 23.0 0.2 0.00098 19.6 0.1 2.3 1 1 1 2 2 2 1 Immunoglobulin domain ig PF00047.23 001305029.1_22423001_1 - 0.0025 17.8 0.0 0.006 16.6 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain MHC_I_3 PF16497.3 001305029.1_22423001_1 - 0.003 16.9 0.0 0.0038 16.6 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain Ig_2 PF13895.4 001305029.1_22423001_1 - 0.033 14.4 0.0 0.061 13.5 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain EphA2_TM PF14575.4 001305029.1_22423001_1 - 0.077 13.7 0.0 0.2 12.4 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Protocadherin PF08374.9 001305029.1_22423001_1 - 0.18 11.6 0.0 0.28 11.0 0.0 1.2 1 0 0 1 1 1 0 Protocadherin TNF PF00229.16 001079828.1_22422001_3 - 0.077 12.8 0.2 2.2 8.1 0.0 2.2 1 1 1 2 2 2 0 TNF(Tumour Necrosis Factor) family ARD PF03079.12 001079828.1_22422001_3 - 0.093 12.8 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 ARD/ARD' family tRNA_NucTran2_2 PF13735.4 001079828.1_22422001_3 - 0.18 11.6 0.0 0.27 11.1 0.0 1.2 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative HLH PF00010.24 001009866.1_22421001_1 - 1.7e-18 66.2 0.7 3.1e-18 65.3 0.7 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain IncA PF04156.12 001009866.1_22421001_1 - 0.0023 17.6 6.0 0.0032 17.1 6.0 1.2 1 0 0 1 1 1 1 IncA protein Filament PF00038.19 001009866.1_22421001_1 - 0.0067 15.9 7.6 0.0076 15.7 7.6 1.1 1 0 0 1 1 1 1 Intermediate filament protein SlyX PF04102.10 001009866.1_22421001_1 - 0.011 16.2 5.4 0.021 15.3 4.0 2.1 1 1 2 3 3 3 0 SlyX bZIP_2 PF07716.13 001009866.1_22421001_1 - 0.016 15.2 2.6 0.016 15.2 2.6 2.3 3 0 0 3 3 3 0 Basic region leucine zipper Rab5-bind PF09311.9 001009866.1_22421001_1 - 0.017 14.4 8.6 0.12 11.6 0.8 2.0 1 1 1 2 2 2 0 Rabaptin-like protein CREPT PF16566.3 001009866.1_22421001_1 - 0.038 14.0 3.4 0.051 13.6 3.4 1.3 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour ZapB PF06005.10 001009866.1_22421001_1 - 0.27 11.6 5.6 0.34 11.3 4.1 1.9 1 1 0 2 2 2 0 Cell division protein ZapB DUF4763 PF15960.3 001009866.1_22421001_1 - 0.28 10.3 7.8 0.55 9.4 7.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4763) ATG16 PF08614.9 001009866.1_22421001_1 - 0.57 10.2 12.9 0.15 12.0 9.1 1.7 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DivIC PF04977.13 001009866.1_22421001_1 - 0.83 9.3 5.0 0.95 9.1 3.9 1.7 1 1 0 1 1 1 0 Septum formation initiator V_ATPase_I PF01496.17 001009866.1_22421001_1 - 0.98 7.1 4.1 1 7.0 4.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4140 PF13600.4 001009866.1_22421001_1 - 5.9 7.3 11.1 1.6e+02 2.7 11.1 2.3 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Glyco_hydro_39 PF01229.15 001305032.1_22424001_1 - 3.2e-205 682.2 0.0 3.7e-205 682.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 39 V-set PF07686.15 001009867.1_22422001_1 - 1.1e-18 67.2 0.0 1.5e-18 66.8 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.4 001009867.1_22422001_1 - 5.6e-08 33.1 0.0 1e-07 32.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.23 001009867.1_22422001_1 - 3.5e-05 23.8 0.0 6.2e-05 22.9 0.0 1.4 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.14 001009867.1_22422001_1 - 0.0013 18.6 0.0 0.022 14.7 0.0 2.1 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 001009867.1_22422001_1 - 0.02 15.1 0.1 0.45 10.8 0.1 2.3 1 1 0 1 1 1 0 Immunoglobulin domain MHC_II_beta PF00969.17 001305030.1_22422001_1 - 7.7e-37 125.2 0.4 1.2e-36 124.6 0.4 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain C1-set PF07654.13 001305030.1_22422001_1 - 2.7e-26 91.7 0.6 4.8e-26 90.9 0.2 1.6 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.4 001305030.1_22422001_1 - 8.2e-06 26.2 0.1 3.2e-05 24.3 0.1 1.9 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.23 001305030.1_22422001_1 - 0.0003 20.8 0.2 0.00066 19.7 0.2 1.5 1 1 0 1 1 1 1 Immunoglobulin domain DUF202 PF02656.13 001305030.1_22422001_1 - 0.011 16.1 0.0 0.022 15.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Marek_A PF02124.13 001305030.1_22422001_1 - 0.068 12.9 0.0 0.095 12.4 0.0 1.2 1 0 0 1 1 1 0 Marek's disease glycoprotein A DUF2142 PF09913.7 001305030.1_22422001_1 - 0.1 11.3 0.0 0.22 10.2 0.0 1.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2142) TF_Otx PF03529.11 001173443.1_22423001_2 - 6.7e-15 55.1 9.7 1.9e-14 53.7 9.7 1.7 1 0 0 1 1 1 1 Otx1 transcription factor Homeobox PF00046.27 001173443.1_22423001_3 - 4.4e-22 77.5 3.0 8e-22 76.7 3.0 1.4 1 0 0 1 1 1 1 Homeobox domain V-set PF07686.15 001305024.1_22422001_1 - 2.1e-14 53.5 0.2 3.8e-14 52.6 0.2 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.23 001305024.1_22422001_1 - 4.6e-05 23.4 2.7 0.00065 19.7 1.2 2.9 2 1 0 2 2 2 1 Immunoglobulin domain I-set PF07679.14 001305024.1_22422001_1 - 5.1e-05 23.1 0.0 0.00014 21.7 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.4 001305024.1_22422001_1 - 0.00074 19.7 1.1 0.0085 16.3 1.1 2.5 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.4 001305024.1_22422001_1 - 0.004 17.6 3.5 0.0046 17.4 0.6 2.5 2 1 0 2 2 2 1 Immunoglobulin domain Receptor_2B4 PF11465.6 001305024.1_22422001_1 - 0.0096 16.0 0.0 0.021 14.9 0.0 1.5 1 0 0 1 1 1 1 Natural killer cell receptor 2B4 MAGE PF01454.17 001009368.1_22424001_1 - 9.3e-16 58.0 5.5 3.4e-15 56.2 0.1 2.6 2 1 0 2 2 2 1 MAGE family MAGE_N PF12440.6 001009368.1_22424001_1 - 4.2e-12 46.4 15.8 4.2e-12 46.4 15.8 2.2 2 0 0 2 2 2 1 Melanoma associated antigen family N terminal p450 PF00067.20 001009371.2_22424001_3 - 3e-137 458.0 0.0 3.7e-137 457.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Steroid_dh PF02544.14 136739.1_26226120_1 - 9.1e-10 38.6 0.0 2.3e-09 37.2 0.0 1.7 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase Steroid_dh PF02544.14 136739.1_26226120_2 - 2.3e-50 170.3 0.6 4e-50 169.6 0.6 1.4 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.10 136739.1_26226120_2 - 6e-07 29.1 0.2 9.5e-07 28.4 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ApoM PF11032.6 045828.1_26222120_2 - 1.6e-22 80.0 0.0 2.2e-22 79.5 0.0 1.1 1 0 0 1 1 1 1 ApoM domain ApoM PF11032.6 045828.1_26222120_3 - 1.6e-52 177.8 0.1 2e-52 177.5 0.1 1.1 1 0 0 1 1 1 1 ApoM domain TPR_12 PF13424.4 146621.1_26226120_1 - 3.9e-08 33.3 0.7 0.00016 21.7 1.0 2.6 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.4 146621.1_26226120_1 - 7e-06 25.6 0.4 0.16 12.0 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.15 146621.1_26226120_1 - 0.0004 20.1 0.8 0.6 10.2 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.26 146621.1_26226120_1 - 0.0017 18.0 0.1 0.5 10.1 0.1 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat RPN7 PF10602.7 146621.1_26226120_1 - 0.002 17.7 0.2 0.0032 17.0 0.2 1.2 1 0 0 1 1 1 1 26S proteasome subunit RPN7 TPR_8 PF13181.4 146621.1_26226120_1 - 0.0066 16.4 0.1 0.19 11.9 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.4 146621.1_26226120_1 - 0.12 13.0 0.2 7.2 7.3 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat SieB PF14163.4 146621.1_26226120_1 - 0.4 10.0 1.0 0.63 9.4 1.0 1.2 1 0 0 1 1 1 0 Super-infection exclusion protein B TPR_2 PF07719.15 146621.1_26226120_2 - 0.00061 19.6 0.1 1.4 9.1 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.26 146621.1_26226120_2 - 0.064 13.0 0.2 19 5.2 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Pkinase PF00069.23 136583.1_26229120_1 - 0.022 14.0 0.0 0.031 13.5 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain Pkinase PF00069.23 136583.1_26229120_2 - 3.6e-54 183.8 0.0 5e-54 183.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 136583.1_26229120_2 - 6.8e-28 97.5 0.0 9.4e-28 97.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 136583.1_26229120_2 - 2.4e-06 27.0 0.2 3.6e-06 26.4 0.2 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 136583.1_26229120_2 - 0.00033 20.0 0.0 0.00049 19.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 136583.1_26229120_2 - 0.0049 16.4 0.4 0.0078 15.7 0.4 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.21 136583.1_26229120_2 - 0.005 16.6 0.0 0.0076 16.1 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Homeobox_KN PF05920.9 136583.1_26229120_2 - 0.11 12.3 0.1 0.21 11.4 0.1 1.5 1 0 0 1 1 1 0 Homeobox KN domain Peptidase_C14 PF00656.20 147250.1_26229120_1 - 3.5e-22 79.4 0.0 5.4e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 Caspase domain DUF1725 PF08333.9 147250.1_26229120_2 - 4.3e-07 29.3 0.9 8.8e-07 28.3 0.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1725) DED PF01335.19 147250.1_26229120_3 - 2.1e-34 117.5 10.7 3.1e-24 84.9 3.2 2.4 2 0 0 2 2 2 2 Death effector domain RVT_1 PF00078.25 147250.1_26229120_3 - 9.2e-17 61.2 0.5 2.8e-16 59.6 0.5 1.7 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) 7tm_1 PF00001.19 000912.4_26229001_2 - 1.3e-58 198.2 22.2 2e-58 197.6 22.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.7 000912.4_26229001_2 - 4.4e-11 42.5 22.3 7.1e-11 41.8 22.3 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Syja_N PF02383.16 001194852.3_29628001_1 - 5.1e-92 308.4 0.6 6.5e-92 308.0 0.6 1.1 1 0 0 1 1 1 1 SacI homology domain RCDG1 PF15725.3 152796.1_32924120_2 - 1.3 9.4 15.9 3.1 8.2 15.9 1.5 1 0 0 1 1 1 0 Renal cancer differentiation gene 1 protein SelP_N PF04592.12 152796.1_32924120_3 - 0.25 10.6 27.2 0.4 9.9 27.2 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Zip PF02535.20 152796.1_32924120_3 - 0.71 8.9 10.1 1.2 8.1 10.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter NicO PF03824.14 152796.1_32924120_3 - 3.4 6.8 14.6 5.2 6.2 14.6 1.2 1 0 0 1 1 1 0 High-affinity nickel-transport protein DUF2796 PF10986.6 152796.1_32924120_3 - 8 6.3 26.5 13 5.5 26.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) Piwi PF02171.15 001317173.1_32929001_1 - 1e-108 363.0 0.0 1.4e-108 362.5 0.0 1.1 1 0 0 1 1 1 1 Piwi domain ArgoMid PF16487.3 001317173.1_32929001_1 - 4.5e-34 116.4 0.1 9.5e-34 115.4 0.1 1.6 1 0 0 1 1 1 1 Mid domain of argonaute PAZ PF02170.20 001317173.1_32929001_1 - 2.7e-29 101.6 1.4 4.3e-29 101.0 1.4 1.3 1 0 0 1 1 1 1 PAZ domain ArgoN PF16486.3 001317173.1_32929001_1 - 1.5e-26 93.5 0.0 2.6e-26 92.7 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.8 001317173.1_32929001_1 - 4.1e-23 80.6 0.0 7.6e-23 79.8 0.0 1.5 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.3 001317173.1_32929001_1 - 1.5e-15 57.1 0.1 2.9e-15 56.2 0.1 1.5 1 0 0 1 1 1 1 Argonaute linker 2 domain MIP PF00230.18 001257671.2_29629001_2 - 5.3e-71 238.8 17.0 7.9e-71 238.2 17.0 1.2 1 0 0 1 1 1 1 Major intrinsic protein Ldh_1_N PF00056.21 002300.7_26223001_1 - 7.5e-50 168.6 0.9 1.1e-49 168.0 0.9 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 002300.7_26223001_1 - 1.5e-23 83.4 0.0 2.9e-23 82.5 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.14 002300.7_26223001_1 - 0.0013 18.2 0.0 0.0043 16.5 0.0 1.8 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase Ldh_1_N PF00056.21 001320086.1_29623001_2 - 7.2e-50 168.6 0.9 1.1e-49 168.0 0.9 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 001320086.1_29623001_2 - 1.5e-23 83.5 0.0 2.9e-23 82.5 0.0 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.14 001320086.1_29623001_2 - 0.0013 18.2 0.0 0.0043 16.5 0.0 1.9 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase Ldh_1_N PF00056.21 174100.2_06523001_1 - 1.2e-49 167.9 0.8 1.7e-49 167.4 0.8 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.16 174100.2_06523001_1 - 2.9e-23 82.5 0.0 5.7e-23 81.5 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.14 174100.2_06523001_1 - 0.0018 17.7 0.2 0.0044 16.4 0.0 1.7 2 0 0 2 2 2 1 Family 4 glycosyl hydrolase Pkinase PF00069.23 001320562.1_29629001_3 - 5.4e-63 212.7 0.0 6.9e-63 212.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001320562.1_29629001_3 - 1.2e-28 100.0 0.1 1.7e-28 99.5 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 001320562.1_29629001_3 - 1.1e-06 28.1 0.2 1.7e-06 27.4 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 001320562.1_29629001_3 - 0.00047 19.4 0.0 0.00086 18.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 001320562.1_29629001_3 - 0.0016 17.9 0.3 0.0029 17.1 0.3 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.21 001320562.1_29629001_3 - 0.0028 17.5 0.0 0.0045 16.8 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.23 001260857.2_29629001_3 - 5.4e-63 212.7 0.0 6.9e-63 212.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001260857.2_29629001_3 - 1.2e-28 100.0 0.1 1.7e-28 99.5 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 001260857.2_29629001_3 - 1.1e-06 28.1 0.2 1.7e-06 27.4 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 001260857.2_29629001_3 - 0.00047 19.4 0.0 0.00086 18.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 001260857.2_29629001_3 - 0.0016 17.9 0.3 0.0029 17.1 0.3 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.21 001260857.2_29629001_3 - 0.0028 17.5 0.0 0.0045 16.8 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.23 001083728.3_06526001_2 - 2.6e-63 213.7 0.0 3.5e-63 213.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001083728.3_06526001_2 - 6.4e-29 100.9 0.0 9e-29 100.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.12 001083728.3_06526001_2 - 6.3e-07 28.8 0.2 9.9e-07 28.2 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.4 001083728.3_06526001_2 - 0.00026 20.3 0.0 0.0005 19.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 001083728.3_06526001_2 - 0.00095 18.7 0.3 0.0018 17.8 0.3 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.21 001083728.3_06526001_2 - 0.0017 18.2 0.0 0.0029 17.5 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family F-box-like PF12937.5 176982.2_32925001_1 - 4.9e-10 39.0 0.9 4.9e-10 39.0 0.9 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.31 176982.2_32925001_1 - 4.1e-08 32.8 1.5 1.1e-06 28.2 0.2 2.5 2 0 0 2 2 2 1 F-box domain ASD2 PF08687.9 001359158.1_32929001_1 - 6.5e-114 380.3 11.0 1.1e-113 379.5 11.0 1.4 1 0 0 1 1 1 1 Apx/Shroom domain ASD2 Ldh_1_C PF02866.16 033235.2_45724001_3 - 3e-45 154.0 0.0 7e-45 152.8 0.0 1.6 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.21 033235.2_45724001_3 - 1.8e-39 134.9 0.2 3e-39 134.2 0.2 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain CheY-binding PF09078.9 033235.2_45724001_3 - 0.026 14.5 0.2 0.063 13.3 0.0 1.7 2 0 0 2 2 2 0 CheY binding DUF4809 PF16067.3 033235.2_45724001_3 - 0.052 13.6 0.5 0.3 11.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4809) Lipocalin PF00061.21 001045495.1_39722001_1 - 1.8e-22 80.0 0.0 2.2e-22 79.7 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_2 PF08212.10 001045495.1_39722001_1 - 2.3e-06 27.5 0.0 3.4e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Lipocalin-like domain Triabin PF03973.11 001045495.1_39722001_1 - 0.015 15.0 0.6 0.085 12.6 0.6 2.0 1 1 0 1 1 1 0 Triabin Parathyroid PF01279.15 214401.1_49822001_1 - 8.4e-07 29.5 0.3 1.2e-06 28.9 0.3 1.3 1 0 0 1 1 1 1 Parathyroid hormone family Annexin PF00191.18 019905.1_45723001_1 - 2.6e-91 299.6 10.4 1.7e-26 91.9 0.7 4.2 4 0 0 4 4 4 4 Annexin Kazal_2 PF07648.13 001003662.1_49823001_3 - 1.3e-35 121.2 32.5 2e-13 50.2 1.6 4.7 4 1 0 4 4 4 3 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 001003662.1_49823001_3 - 6.4e-20 70.8 35.7 2e-07 30.8 4.6 4.0 3 0 0 3 3 3 3 Kazal-type serine protease inhibitor domain FOLN PF09289.8 001003662.1_49823001_3 - 4.6e-07 29.8 12.7 4.6e-07 29.8 12.7 4.7 4 1 0 4 4 4 1 Follistatin/Osteonectin-like EGF domain zf-H2C2_2 PF13465.4 001301320.1_21029001_1 - 2.2e-40 135.2 41.8 2.4e-09 37.1 0.4 7.1 7 0 0 7 7 6 5 Zinc-finger double domain SCAN PF02023.15 001301320.1_21029001_1 - 3.1e-40 135.7 1.8 5.6e-40 134.9 1.8 1.4 1 0 0 1 1 1 1 SCAN domain zf-C2H2 PF00096.24 001301320.1_21029001_1 - 2.8e-34 115.5 42.0 1.6e-06 28.1 0.4 7.0 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.4 001301320.1_21029001_1 - 6.5e-11 42.0 39.0 0.039 14.7 0.4 7.2 6 0 0 6 6 6 6 C2H2-type zinc finger KRAB PF01352.25 001301320.1_21029001_1 - 1.9e-10 40.1 0.0 3.2e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 KRAB box zf-C2H2_6 PF13912.4 001301320.1_21029001_1 - 4.9e-09 35.8 31.2 0.32 10.9 1.9 6.5 6 0 0 6 6 6 5 C2H2-type zinc finger Zn-ribbon_8 PF09723.8 001301320.1_21029001_1 - 2.1e-05 24.4 24.8 0.02 14.9 1.4 4.5 3 1 2 5 5 5 4 Zinc ribbon domain zf-C2H2_11 PF16622.3 001301320.1_21029001_1 - 0.00036 20.1 29.1 0.00085 18.9 3.9 6.2 6 0 0 6 6 6 3 zinc-finger C2H2-type DZR PF12773.5 001301320.1_21029001_1 - 0.018 15.0 18.1 6.4 6.8 6.4 3.7 1 1 1 2 2 2 0 Double zinc ribbon XPA_N PF01286.16 001301320.1_21029001_1 - 0.034 14.0 26.8 11 6.1 0.3 6.6 6 0 0 6 6 6 0 XPA protein N-terminal C1_4 PF07975.10 001301320.1_21029001_1 - 2 8.6 19.5 1 9.5 1.1 4.1 2 1 2 4 4 4 0 TFIIH C1-like domain zinc_ribbon_15 PF17032.3 001301320.1_21029001_1 - 7.8 7.2 19.4 0.73 10.5 1.5 3.8 1 1 4 5 5 5 0 zinc-ribbon family Fer2 PF00111.25 214065.1_49822001_2 - 5.6e-08 32.5 0.3 8.1e-08 32.0 0.3 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Lipoxygenase PF00305.17 001139.2_26226001_1 - 1.4e-62 212.0 0.0 2.8e-62 211.0 0.0 1.4 1 1 0 1 1 1 1 Lipoxygenase PLAT PF01477.21 001139.2_26226001_1 - 3e-22 79.3 0.0 5.2e-22 78.5 0.0 1.4 1 0 0 1 1 1 1 PLAT/LH2 domain PSP94 PF05825.9 213852.1_49822001_3 - 1.2e-42 144.3 13.5 1.5e-42 144.0 13.5 1.1 1 0 0 1 1 1 1 Beta-microseminoprotein (PSP-94) TILa PF12714.5 213852.1_49822001_3 - 0.0021 17.8 10.7 0.0044 16.8 10.7 1.6 1 1 0 1 1 1 1 TILa domain VWC PF00093.16 213852.1_49822001_3 - 0.39 10.9 16.4 0.31 11.3 14.2 2.0 1 1 0 1 1 1 0 von Willebrand factor type C domain Uteroglobin PF01099.15 001048153.1_22421001_2 - 3.3e-22 78.3 0.6 4.2e-22 78.0 0.6 1.1 1 0 0 1 1 1 1 Uteroglobin family TNRC6-PABC_bdg PF16608.3 144812.2_32929001_1 - 2.3e-108 362.2 26.6 2.3e-108 362.2 26.6 7.3 4 2 5 9 9 9 1 TNRC6-PABC binding domain Ago_hook PF10427.7 144812.2_32929001_1 - 3e-20 73.3 36.2 3e-20 73.3 36.2 9.5 3 2 4 8 8 8 1 Argonaute hook RRM_occluded PF16842.3 144812.2_32929001_1 - 0.00094 18.9 0.0 0.0019 17.9 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_1 PF00076.20 144812.2_32929001_1 - 0.0039 16.8 0.0 0.0076 15.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Gal-3-0_sulfotr PF06990.9 213778.1_49823001_1 - 2.3e-159 530.5 0.4 2.6e-159 530.3 0.4 1.0 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.12 213778.1_49823001_1 - 0.034 13.9 0.0 0.11 12.3 0.0 1.8 2 0 0 2 2 2 0 Sulfotransferase family SDF PF00375.16 001082378.1_37926001_3 - 2.4e-120 402.0 25.5 2.9e-120 401.8 25.5 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family TGFb_propeptide PF00688.16 214198.1_49826001_1 - 4.9e-37 127.9 0.0 6.6e-37 127.4 0.0 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.18 214198.1_49826001_1 - 5.7e-24 84.9 1.3 1.2e-23 83.8 1.3 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain Cementoin PF10511.7 001004032.2_49822001_1 - 6.1e-16 57.4 46.6 3.5e-07 29.7 1.6 6.9 6 1 1 7 7 7 4 Trappin protein transglutaminase binding domain WAP PF00095.19 001004032.2_49822001_1 - 3.1e-09 36.9 12.1 5e-09 36.3 12.1 1.4 1 0 0 1 1 1 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Glutenin_hmw PF03157.11 001004032.2_49822001_1 - 0.018 13.3 13.4 0.027 12.8 13.4 1.1 1 0 0 1 1 1 0 High molecular weight glutenin subunit Squash PF00299.16 001004032.2_49822001_1 - 2 8.4 13.6 3.6 7.5 0.6 2.5 2 0 0 2 2 2 0 Squash family serine protease inhibitor Hormone_recep PF00104.28 009107.3_32925001_1 - 4.2e-38 130.9 0.0 6.9e-38 130.2 0.0 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Nuc_recep-AF1 PF11825.6 009107.3_32925001_1 - 1.3e-36 125.0 14.7 2.4e-36 124.1 14.7 1.5 1 0 0 1 1 1 1 Nuclear/hormone receptor activator site AF-1 zf-C4 PF00105.16 009107.3_32925001_1 - 3.5e-31 107.3 15.7 3.5e-31 107.3 15.7 1.9 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) DUF3915 PF13054.4 009107.3_32925001_2 - 0.51 10.2 4.9 0.75 9.7 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF3915 PF13054.4 009107.3_32925001_3 - 0.17 11.7 4.5 0.34 10.8 4.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) APG5 PF04106.10 001037152.1_49824001_3 - 2.7e-59 200.1 0.1 3.5e-59 199.7 0.1 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 DcpS_C PF11969.6 213790.1_49823001_1 - 2.5e-32 111.6 0.0 4.4e-32 110.8 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.10 213790.1_49823001_1 - 1.2e-20 74.2 0.0 2.1e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal BSMAP PF12280.6 001044558.1_49824001_3 - 1.2e-69 234.0 1.3 1.2e-69 234.0 1.3 2.1 2 0 0 2 2 2 1 Brain specific membrane anchored protein Acetyltransf_1 PF00583.23 001129962.2_49822001_2 - 3.2e-18 65.9 0.0 5.2e-18 65.3 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.5 001129962.2_49822001_2 - 1.9e-10 40.9 0.1 4.3e-10 39.7 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.5 001129962.2_49822001_2 - 2.9e-07 30.3 0.0 4.6e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.8 001129962.2_49822001_2 - 2.5e-05 24.0 0.0 4.9e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.4 001129962.2_49822001_2 - 8.5e-05 22.5 0.0 0.00019 21.3 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.5 001129962.2_49822001_2 - 0.051 14.1 0.0 0.066 13.7 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.3 001129962.2_49822001_2 - 0.12 11.6 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase SK_channel PF03530.12 002250.2_26225001_1 - 4.6e-37 126.4 0.1 4.6e-37 126.4 0.1 1.6 2 0 0 2 2 2 1 Calcium-activated SK potassium channel CaMBD PF02888.14 002250.2_26225001_1 - 3e-27 94.5 8.5 5.6e-27 93.7 8.5 1.5 1 0 0 1 1 1 1 Calmodulin binding domain Ion_trans_2 PF07885.14 002250.2_26225001_1 - 4.2e-15 55.4 4.1 1.2e-14 53.9 4.1 1.8 1 0 0 1 1 1 1 Ion channel Ion_trans PF00520.29 002250.2_26225001_1 - 0.0083 15.3 4.0 0.045 12.8 3.4 2.1 1 1 1 2 2 2 1 Ion transport protein zf-C4 PF00105.16 214179.1_49826001_1 - 2.4e-31 107.8 12.4 4.6e-31 106.9 12.4 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 214179.1_49826001_1 - 2e-23 82.9 4.8 4.4e-23 81.8 4.8 1.5 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Thyroglobulin_1 PF00086.16 214099.1_49822001_1 - 4.2e-19 67.8 2.5 1.1e-18 66.5 2.5 1.7 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat IGFBP PF00219.16 214099.1_49822001_1 - 6.4e-11 42.6 22.4 6.4e-11 42.6 22.4 2.2 2 0 0 2 2 2 1 Insulin-like growth factor binding protein Ank_2 PF12796.5 207608.1_45727001_1 - 1.5e-74 246.4 23.9 1.4e-12 47.9 0.8 8.6 2 1 6 9 9 9 8 Ankyrin repeats (3 copies) Ank_4 PF13637.4 207608.1_45727001_1 - 1.5e-58 194.4 22.3 7.1e-09 35.9 0.1 11.1 6 3 5 11 11 11 10 Ankyrin repeats (many copies) Ank PF00023.28 207608.1_45727001_1 - 5.7e-58 190.8 27.7 5.5e-08 32.8 0.0 15.2 15 0 0 15 15 15 12 Ankyrin repeat Ank_3 PF13606.4 207608.1_45727001_1 - 2.5e-55 177.8 21.5 2.1e-05 24.4 0.0 16.2 17 0 0 17 17 17 12 Ankyrin repeat Ank_5 PF13857.4 207608.1_45727001_1 - 3.5e-49 163.9 23.0 1.9e-07 31.1 0.2 12.1 3 3 7 12 12 12 9 Ankyrin repeats (many copies) Ion_trans PF00520.29 207608.1_45727001_1 - 1.5e-10 40.6 22.1 2.7e-10 39.8 22.1 1.4 1 0 0 1 1 1 1 Ion transport protein SchA_CurD PF04486.10 207608.1_45727001_1 - 0.19 11.7 3.9 0.42 10.6 0.0 3.5 5 0 0 5 5 5 0 SchA/CurD like domain GMAP PF06540.9 214234.1_49822001_3 - 2.5e-30 104.2 0.1 3.7e-30 103.6 0.1 1.3 1 0 0 1 1 1 1 Galanin message associated peptide (GMAP) Galanin PF01296.16 214234.1_49822001_3 - 3.8e-20 71.4 2.8 6.1e-20 70.8 2.8 1.3 1 0 0 1 1 1 1 Galanin TCTP PF00838.15 214373.1_49822001_2 - 1.6e-83 278.8 0.6 1.9e-83 278.6 0.6 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein Vps55 PF04133.12 001145388.1_49825001_2 - 2.8e-35 120.7 5.2 6.6e-35 119.5 5.2 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting 55 SCAMP PF04144.11 214245.1_49828001_3 - 1.6e-72 243.3 17.6 1.6e-72 243.3 17.6 1.8 2 0 0 2 2 2 1 SCAMP family GCR PF02155.13 001082147.1_37925001_1 - 7.2e-165 548.4 3.4 9.1e-165 548.1 3.4 1.1 1 0 0 1 1 1 1 Glucocorticoid receptor Hormone_recep PF00104.28 001082147.1_37925001_1 - 2.9e-30 105.3 5.6 1.1e-29 103.4 4.8 2.0 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001082147.1_37925001_1 - 3.7e-28 97.6 13.6 6.6e-28 96.8 13.6 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) PGI PF00342.17 214330.1_49824001_3 - 1.3e-266 884.7 0.0 1.5e-266 884.5 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase HSP90 PF00183.16 001163873.1_21026001_1 - 4e-230 764.9 28.7 4e-230 764.9 28.7 1.7 1 1 1 2 2 2 1 Hsp90 protein HATPase_c PF02518.24 001163873.1_21026001_1 - 1.2e-13 51.5 0.4 2.1e-13 50.7 0.4 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.4 001163873.1_21026001_1 - 4.9e-11 42.5 0.4 1.2e-10 41.2 0.4 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF4518 PF15008.4 001163873.1_21026001_1 - 0.058 12.4 3.5 0.93 8.5 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) DUF913 PF06025.10 001163873.1_21026001_1 - 6.5 5.5 10.1 5.1 5.8 1.5 2.8 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) Cofilin_ADF PF00241.18 001004031.1_49824001_3 - 7.7e-28 97.1 0.2 1.1e-27 96.6 0.2 1.2 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein ATP-synt PF00231.17 020615.4_32923001_3 - 3.5e-80 269.6 5.7 4.3e-80 269.3 5.7 1.1 1 0 0 1 1 1 1 ATP synthase Mito_carr PF00153.25 001082686.1_37922001_2 - 1.1e-68 227.1 5.5 2.4e-25 88.1 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Ig_3 PF13927.4 023983.3_45726001_1 - 1.7e-37 127.7 5.6 1.9e-09 37.8 0.0 5.9 6 0 0 6 6 6 5 Immunoglobulin domain Ig_2 PF13895.4 023983.3_45726001_1 - 2.2e-28 98.3 2.6 3.6e-07 30.3 0.0 5.9 6 0 0 6 6 6 4 Immunoglobulin domain C2-set_2 PF08205.10 023983.3_45726001_1 - 5.1e-27 93.6 6.9 1e-20 73.5 0.0 4.8 5 0 0 5 5 5 3 CD80-like C2-set immunoglobulin domain ig PF00047.23 023983.3_45726001_1 - 3.3e-25 87.9 3.9 2.2e-06 27.6 0.0 6.8 6 1 0 6 6 6 4 Immunoglobulin domain I-set PF07679.14 023983.3_45726001_1 - 2.6e-24 85.0 1.6 0.00011 22.0 0.4 7.0 5 2 0 5 5 5 4 Immunoglobulin I-set domain V-set PF07686.15 023983.3_45726001_1 - 2.4e-18 66.2 2.5 7.4e-06 25.9 0.0 6.3 6 2 2 8 8 8 4 Immunoglobulin V-set domain DUF4366 PF14283.4 023983.3_45726001_1 - 0.013 14.9 0.0 0.046 13.1 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) DUF4448 PF14610.4 023983.3_45726001_1 - 0.079 12.6 0.1 0.18 11.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) MG1 PF11974.6 023983.3_45726001_1 - 0.094 12.6 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Alpha-2-macroglobulin MG1 domain DUF912 PF06024.10 023983.3_45726001_1 - 0.12 12.6 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF4198 PF10670.7 023983.3_45726001_1 - 0.15 12.3 0.0 0.31 11.3 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4198) DUF3915 PF13054.4 023983.3_45726001_1 - 1.5 8.7 5.9 2.9 7.8 5.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) zf-C4 PF00105.16 001097414.1_49825001_1 - 2.2e-28 98.3 15.0 4.5e-28 97.4 15.0 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001097414.1_49825001_1 - 4.7e-23 81.7 0.5 8e-23 81.0 0.1 1.5 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-RRPl_C4 PF17026.3 001097414.1_49825001_1 - 0.18 11.8 2.5 0.32 11.0 2.5 1.3 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type Cyt-b5 PF00173.26 022245.1_45722001_2 - 7.8e-23 80.3 0.1 1.1e-22 79.8 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Endosulfine PF04667.15 214175.1_49821001_1 - 4.9e-10 39.3 3.5 4.9e-10 39.3 3.5 1.5 1 1 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Ntox30 PF15532.4 214175.1_49821001_1 - 0.047 13.9 0.1 0.062 13.5 0.1 1.5 1 1 0 1 1 1 0 Bacterial toxin 30 E1-E2_ATPase PF00122.18 213865.1_49828001_2 - 2.8e-64 216.3 1.3 2.8e-64 216.3 1.3 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.19 213865.1_49828001_2 - 2.9e-46 157.4 2.2 6.9e-46 156.1 2.2 1.7 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.4 213865.1_49828001_2 - 3.9e-21 74.8 0.5 7.1e-21 74.0 0.5 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.24 213865.1_49828001_2 - 1.1e-17 64.9 0.0 8.8e-17 61.9 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.24 213865.1_49828001_2 - 8.8e-17 60.4 0.9 4.6e-16 58.1 0.1 2.4 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.10 213865.1_49828001_2 - 2.2e-05 24.2 0.5 4.3e-05 23.3 0.5 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.5 213865.1_49828001_2 - 0.0011 19.3 0.0 0.0046 17.3 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase WRW PF10206.7 001097464.1_49821001_1 - 8.6e-19 67.7 0.0 1.4e-18 67.0 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial F1F0-ATP synthase, subunit f Acetyltransf_16 PF05301.9 001123123.1_49822001_1 - 3.9e-77 257.8 0.0 4.6e-77 257.5 0.0 1.0 1 0 0 1 1 1 1 GNAT acetyltransferase, Mec-17 Acetyltransf_7 PF13508.5 001123123.1_49822001_1 - 0.0042 17.3 0.0 0.0079 16.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.23 001123123.1_49822001_1 - 0.011 15.8 0.0 0.017 15.2 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.5 001123123.1_49822001_1 - 0.042 13.7 0.1 0.08 12.7 0.1 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain zf-Di19 PF05605.10 001001869.1_49822001_3 - 1e-16 60.8 2.3 1e-16 60.8 2.3 3.8 2 1 0 2 2 1 1 Drought induced 19 protein (Di19), zinc-binding zf-RING_UBOX PF13445.4 001001869.1_49822001_3 - 2e-09 37.2 9.1 2e-09 37.2 9.1 3.2 3 1 1 4 4 4 1 RING-type zinc-finger zf-C3HC4 PF00097.23 001001869.1_49822001_3 - 3.9e-08 32.9 11.5 3.9e-08 32.9 11.5 3.7 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.4 001001869.1_49822001_3 - 6.4e-08 32.2 9.7 6.4e-08 32.2 9.7 4.0 3 2 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001001869.1_49822001_3 - 2.1e-07 30.5 12.8 2.1e-07 30.5 12.8 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001001869.1_49822001_3 - 4.2e-07 30.0 11.2 4.2e-07 30.0 11.2 3.6 3 1 1 4 4 4 1 Ring finger domain zf-C3HC4_4 PF15227.4 001001869.1_49822001_3 - 6.1e-07 29.4 13.5 6.1e-07 29.4 13.5 3.5 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.4 001001869.1_49822001_3 - 8.3e-07 28.7 11.1 8.3e-07 28.7 11.1 3.7 3 1 0 3 3 3 1 zinc-RING finger domain zf-RING_6 PF14835.4 001001869.1_49822001_3 - 0.00011 21.9 3.3 0.00011 21.9 3.3 2.3 2 0 0 2 2 2 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.4 001001869.1_49822001_3 - 0.00065 19.4 10.5 0.00065 19.4 10.5 3.5 4 0 0 4 4 4 1 Prokaryotic RING finger family 4 U-box PF04564.13 001001869.1_49822001_3 - 0.007 16.4 0.0 0.018 15.1 0.0 1.7 2 0 0 2 2 2 1 U-box domain zf-C2H2_4 PF13894.4 001001869.1_49822001_3 - 0.045 14.5 0.7 0.045 14.5 0.7 5.5 5 1 1 6 6 6 0 C2H2-type zinc finger zf-RING_4 PF14570.4 001001869.1_49822001_3 - 9.5 5.9 21.5 0.76 9.4 4.5 4.7 5 0 0 5 5 5 0 RING/Ubox like zinc-binding domain Pkinase PF00069.23 214381.1_49825001_1 - 4.3e-75 252.3 0.0 6.5e-75 251.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain CaMKII_AD PF08332.8 214381.1_49825001_1 - 4.7e-60 201.2 0.0 7.4e-60 200.6 0.0 1.3 1 0 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II association domain Pkinase_Tyr PF07714.15 214381.1_49825001_1 - 1.7e-31 109.4 0.0 3.2e-31 108.4 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase DUF4440 PF14534.4 214381.1_49825001_1 - 5.6e-09 36.2 0.0 9.7e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_3 PF13474.4 214381.1_49825001_1 - 9.1e-09 35.5 0.0 1.9e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 SnoaL-like domain APH PF01636.21 214381.1_49825001_1 - 0.0063 16.3 0.0 4.5 7.0 0.0 2.3 1 1 0 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.12 214381.1_49825001_1 - 0.0069 15.6 0.0 0.015 14.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SnoaL_4 PF13577.4 214381.1_49825001_1 - 0.0093 16.0 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_2 PF12680.5 214381.1_49825001_1 - 0.027 15.0 0.0 0.055 14.0 0.0 1.5 1 0 0 1 1 1 0 SnoaL-like domain Hormone_1 PF00103.18 001043341.1_22422001_2 - 5.4e-79 264.8 0.2 6.4e-79 264.5 0.2 1.0 1 0 0 1 1 1 1 Somatotropin hormone family KIAA1430 PF13879.4 001043341.1_22422001_2 - 0.047 14.3 0.0 0.28 11.8 0.0 1.9 2 0 0 2 2 2 0 KIAA1430 homologue Prog_receptor PF02161.13 001082267.1_37926001_3 - 0 1085.9 57.9 0 1085.6 57.9 1.0 1 0 0 1 1 1 1 Progesterone receptor Hormone_recep PF00104.28 001082267.1_37926001_3 - 3e-29 102.0 5.6 4.7e-29 101.3 5.6 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001082267.1_37926001_3 - 2.5e-26 91.8 15.7 3.9e-26 91.2 15.7 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) 7tm_1 PF00001.19 053897.2_45727001_1 - 3.5e-40 137.8 19.4 6.4e-40 136.9 19.4 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CENP-B_dimeris PF09026.8 053897.2_45727001_2 - 0.076 13.3 8.8 0.13 12.5 8.8 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain ADH_N_2 PF16884.3 214385.1_49823001_2 - 2.3e-38 130.3 0.0 4.2e-38 129.4 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.24 214385.1_49823001_2 - 2.9e-23 82.1 0.0 4.8e-23 81.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.4 214385.1_49823001_2 - 7.5e-09 36.6 0.0 1.9e-08 35.3 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF106 PF01956.14 001167585.1_49822001_1 - 2.2e-43 147.8 0.9 2.8e-43 147.5 0.9 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF106 Vpu PF00558.17 001167585.1_49822001_1 - 0.0061 16.2 0.4 0.011 15.3 0.4 1.5 1 0 0 1 1 1 1 Vpu protein DUF4199 PF13858.4 001167585.1_49822001_1 - 0.018 15.3 0.0 0.034 14.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Nucleoside_tran PF01733.16 001167585.1_49822001_1 - 0.082 12.1 1.6 0.092 12.0 0.7 1.5 1 1 1 2 2 2 0 Nucleoside transporter TRAM1 PF08390.9 001167585.1_49822001_1 - 0.15 11.6 0.4 0.45 10.1 0.0 1.9 2 0 0 2 2 2 0 TRAM1-like protein DivIC PF04977.13 001167585.1_49822001_1 - 0.78 9.4 11.1 0.16 11.6 0.6 2.3 1 1 1 2 2 2 0 Septum formation initiator XhlA PF10779.7 001167585.1_49822001_1 - 2.1 8.5 6.2 6.5 6.9 5.5 2.0 1 1 1 2 2 2 0 Haemolysin XhlA DUF1090 PF06476.10 001167585.1_49822001_1 - 2.1 8.4 13.0 3.2 7.8 13.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) SieB PF14163.4 001167585.1_49822001_1 - 3 7.2 5.9 11 5.4 4.4 2.4 2 1 0 2 2 2 0 Super-infection exclusion protein B p450 PF00067.20 214046.1_49824001_1 - 2.8e-95 319.6 0.1 6.8e-62 209.6 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 adh_short PF00106.23 214073.1_49823001_3 - 1.1e-32 112.9 0.0 9.7e-27 93.6 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.4 214073.1_49823001_3 - 5.5e-26 91.4 0.0 7.4e-20 71.4 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.8 214073.1_49823001_3 - 1.3e-07 31.6 0.0 1.8e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.19 214073.1_49823001_3 - 3.2e-06 26.7 0.0 4.8e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Ammonium_transp PF00909.19 213996.1_49824001_2 - 1.2e-73 248.0 16.8 1.4e-73 247.7 16.8 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Dynamin_M PF01031.18 001079693.2_29625001_3 - 3.4e-87 292.1 10.6 7.7e-87 291.0 10.6 1.6 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.21 001079693.2_29625001_3 - 2.8e-49 167.3 0.1 2.8e-49 167.3 0.1 2.5 2 1 0 2 2 2 1 Dynamin family GED PF02212.16 001079693.2_29625001_3 - 1.1e-25 89.5 2.3 1.1e-25 89.5 2.3 2.4 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.21 001079693.2_29625001_3 - 8.8e-05 22.4 2.0 0.0026 17.7 0.4 3.5 3 2 0 3 3 3 1 50S ribosome-binding GTPase AAA_21 PF13304.4 001079693.2_29625001_3 - 0.012 15.3 0.0 0.034 13.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 001079693.2_29625001_3 - 0.022 14.3 0.1 0.05 13.2 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.4 001079693.2_29625001_3 - 0.026 14.8 0.9 0.82 9.9 0.0 3.0 3 0 0 3 3 3 0 AAA ATPase domain DUF4886 PF16227.3 001079693.2_29625001_3 - 0.033 13.2 1.3 0.065 12.2 1.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4886) DUF2120 PF09893.7 001079693.2_29625001_3 - 0.045 13.7 0.2 0.045 13.7 0.2 2.6 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2120) ABC_tran PF00005.25 001079693.2_29625001_3 - 0.28 11.5 2.5 0.36 11.2 0.0 2.4 2 1 0 2 2 2 0 ABC transporter Dynamin_M PF01031.18 001082492.1_21026001_3 - 1.1e-86 290.5 7.8 2.2e-86 289.5 7.8 1.6 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.21 001082492.1_21026001_3 - 1.6e-47 161.5 0.1 1.6e-47 161.5 0.1 2.4 2 1 0 2 2 2 1 Dynamin family GED PF02212.16 001082492.1_21026001_3 - 2.3e-24 85.2 0.3 7.6e-24 83.6 0.3 2.0 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.21 001082492.1_21026001_3 - 0.0012 18.8 2.6 0.0025 17.8 0.4 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_21 PF13304.4 001082492.1_21026001_3 - 0.019 14.6 0.3 0.056 13.1 0.0 1.9 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 001082492.1_21026001_3 - 0.031 13.8 0.1 0.067 12.8 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.25 001082492.1_21026001_3 - 0.052 13.9 1.0 0.51 10.7 0.0 2.6 2 0 0 2 2 2 0 ABC transporter DUF1043 PF06295.10 001082492.1_21026001_3 - 0.053 13.4 1.5 0.19 11.6 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) UDPG_MGDP_dh_N PF03721.12 001082492.1_21026001_3 - 0.068 12.6 2.7 6 6.3 0.1 2.4 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AAA_16 PF13191.4 001082492.1_21026001_3 - 0.28 11.4 2.3 0.97 9.7 0.0 2.9 3 1 0 3 3 3 0 AAA ATPase domain VPS13_mid_rpt PF16910.3 001018037.1_26229001_3 - 1.4e-80 270.0 15.6 2.9e-71 239.5 1.0 5.3 4 1 0 4 4 4 3 Repeating coiled region of VPS13 VPS13_C PF16909.3 001018037.1_26229001_3 - 9.1e-67 224.1 7.0 4.2e-63 212.1 0.3 3.3 3 0 0 3 3 3 2 Vacuolar-sorting-associated 13 protein C-terminal VPS13 PF16908.3 001018037.1_26229001_3 - 2e-65 220.8 12.1 1.3e-63 214.8 4.1 4.6 5 0 0 5 5 5 2 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.5 001018037.1_26229001_3 - 3.1e-36 123.9 1.4 1.3e-35 121.9 1.4 2.2 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 SHR-BD PF06650.10 001018037.1_26229001_3 - 1.4e-32 113.1 0.8 1.5e-31 109.6 0.2 2.6 2 0 0 2 2 2 1 SHR-binding domain of vacuolar-sorting associated protein 13 ATG_C PF09333.9 001018037.1_26229001_3 - 5.6e-14 52.1 0.2 5.7e-13 48.9 0.0 2.5 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain DUF3482 PF11981.6 001018037.1_26229001_3 - 0.29 10.4 1.6 0.61 9.3 1.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) WD40 PF00400.30 214332.1_49823001_2 - 2.2e-49 164.2 25.3 8.1e-09 35.9 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.5 214332.1_49823001_2 - 2e-10 40.7 0.9 0.0035 17.5 0.0 4.6 1 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.9 214332.1_49823001_2 - 4.9e-05 23.2 0.2 0.0059 16.4 0.0 2.7 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.3 214332.1_49823001_2 - 8.8e-05 21.5 0.0 0.63 8.8 0.0 4.0 2 1 2 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.14 214332.1_49823001_2 - 0.0069 14.8 0.0 0.028 12.8 0.1 1.9 1 1 1 2 2 2 1 Cytochrome D1 heme domain WD40_like PF17005.3 214332.1_49823001_2 - 0.0096 15.1 0.0 3.1 6.9 0.0 2.2 2 0 0 2 2 2 2 WD40-like domain Nup160 PF11715.6 214332.1_49823001_2 - 0.013 14.0 10.7 0.15 10.5 0.1 4.4 3 2 2 5 5 5 0 Nucleoporin Nup120/160 PD40 PF07676.10 214332.1_49823001_2 - 0.46 10.4 3.7 18 5.3 0.0 4.3 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Clusterin PF01093.15 213971.1_49824001_3 - 1.7e-154 514.8 15.6 2e-154 514.6 15.6 1.0 1 0 0 1 1 1 1 Clusterin YqzH PF14164.4 213971.1_49824001_3 - 0.11 12.5 5.7 0.074 13.0 1.7 2.6 3 0 0 3 3 3 0 YqzH-like protein LMBR1 PF04791.14 213971.1_49824001_3 - 0.17 10.6 8.6 9.6 4.8 8.6 2.1 1 1 0 1 1 1 0 LMBR1-like membrane protein CREPT PF16566.3 213971.1_49824001_3 - 1.5 8.8 16.7 0.8 9.7 2.1 3.0 3 0 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour RE_AlwI PF09491.8 213971.1_49824001_3 - 2 7.0 10.9 0.12 11.0 5.2 1.7 2 0 0 2 2 2 0 AlwI restriction endonuclease Pkinase PF00069.23 017175.2_45727001_1 - 9.2e-63 211.9 0.0 2e-61 207.6 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain HR1 PF02185.14 017175.2_45727001_1 - 3.1e-48 161.6 25.0 3.7e-18 65.3 6.9 3.5 3 0 0 3 3 3 3 Hr1 repeat Pkinase_Tyr PF07714.15 017175.2_45727001_1 - 1e-38 133.0 0.0 1.5e-38 132.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.22 017175.2_45727001_1 - 1.4e-10 41.5 1.1 4.5e-10 39.9 1.1 2.0 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.4 017175.2_45727001_1 - 1.4e-05 24.5 0.0 2.3e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like PL48 PF15903.3 017175.2_45727001_1 - 4.7e-05 22.4 1.4 0.18 10.6 0.1 2.3 2 0 0 2 2 2 2 Filopodia upregulated, FAM65 Uds1 PF15456.4 017175.2_45727001_1 - 0.00086 19.3 17.3 0.037 14.1 2.6 3.4 3 0 0 3 3 3 2 Up-regulated During Septation C2 PF00168.28 017175.2_45727001_1 - 0.074 13.2 0.0 0.21 11.7 0.0 1.7 1 1 0 1 1 1 0 C2 domain Endothelin PF00322.15 001009386.1_22423001_1 - 1.3e-22 78.9 15.6 7e-21 73.4 3.6 2.6 2 0 0 2 2 2 2 Endothelin family WHEP-TRS PF00458.18 174218.1_06525001_1 - 2.9e-21 75.2 0.0 5.8e-21 74.3 0.0 1.5 1 0 0 1 1 1 1 WHEP-TRS domain tRNA-synt_1b PF00579.23 174218.1_06525001_1 - 5.4e-18 65.2 0.0 1.2e-17 64.0 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) Sec7 PF01369.18 028195.3_32926001_2 - 4e-63 212.3 0.0 5.5e-63 211.9 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain PH PF00169.27 028195.3_32926001_2 - 3.1e-26 91.8 0.1 5.4e-26 91.0 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.4 028195.3_32926001_2 - 5e-05 23.5 0.1 0.00012 22.3 0.1 1.7 1 1 0 1 1 1 1 Pleckstrin homology domain Syntaxin-6_N PF09177.9 028195.3_32926001_2 - 0.0027 18.1 0.8 1.5 9.3 0.0 2.3 2 0 0 2 2 2 2 Syntaxin 6, N-terminal PH_3 PF14593.4 028195.3_32926001_2 - 0.022 14.8 0.0 0.054 13.5 0.0 1.6 2 0 0 2 2 2 0 PH domain PH_6 PF15406.4 028195.3_32926001_2 - 0.12 12.6 0.1 4 7.6 0.1 2.3 1 1 1 2 2 2 0 Pleckstrin homology domain SLC3A2_N PF16028.3 028195.3_32926001_2 - 0.14 11.6 0.0 0.36 10.3 0.0 1.7 1 0 0 1 1 1 0 Solute carrier family 3 member 2 N-terminus XTBD PF11952.6 001014000.1_45725001_2 - 8.1e-33 111.9 0.0 2.1e-31 107.4 0.0 2.3 2 0 0 2 2 2 1 XRN-Two Binding Domain, XTBD Ish1 PF10281.7 001014000.1_45725001_2 - 0.089 13.0 0.1 0.33 11.2 0.1 2.1 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein Rad60-SLD PF11976.6 001112676.1_49821001_1 - 7.2e-22 76.9 0.1 8.7e-22 76.6 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.21 001112676.1_49821001_1 - 1.4e-18 66.2 0.5 1.7e-18 65.9 0.5 1.1 1 0 0 1 1 1 1 Ubiquitin family CDI PF02234.17 001009870.1_22422001_2 - 1.2e-20 73.3 2.6 2e-20 72.6 2.6 1.4 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor TGF_beta PF00019.18 214028.1_49828001_1 - 6.3e-30 104.0 1.4 6.3e-30 104.0 1.4 2.1 2 0 0 2 2 2 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.16 214028.1_49828001_1 - 1.8e-07 31.0 0.2 7.6e-07 29.0 0.2 1.9 1 1 0 1 1 1 1 TGF-beta propeptide COMM_domain PF07258.12 139108.2_45723001_1 - 3e-15 56.0 0.0 5.5e-15 55.1 0.0 1.5 1 0 0 1 1 1 1 COMM domain zf-C4 PF00105.16 001001523.1_26227001_1 - 1.4e-30 105.4 15.4 1.4e-30 105.4 15.4 2.1 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001001523.1_26227001_1 - 3.5e-17 62.6 2.3 3.5e-17 62.6 2.3 1.6 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor IFRD PF05004.11 001007519.1_49824001_2 - 1.7e-112 375.3 4.9 2.1e-112 375.1 4.9 1.1 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) IFRD_C PF04836.10 001007519.1_49824001_2 - 8.4e-25 87.0 0.6 3e-24 85.2 0.6 2.0 1 0 0 1 1 1 1 Interferon-related protein conserved region UDPGT PF00201.16 001089319.1_37925001_3 - 3e-221 735.4 0.0 3.6e-221 735.1 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001089319.1_37925001_3 - 1.1e-06 28.6 0.0 2e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.4 001089319.1_37925001_3 - 0.035 14.0 0.0 0.08 12.8 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase Family 4 DNA_ligase_A_M PF01068.19 176953.3_32929001_2 - 1.8e-52 177.8 0.4 4.4e-52 176.6 0.4 1.7 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.12 176953.3_32929001_2 - 5.8e-41 140.6 0.8 1.1e-40 139.7 0.8 1.5 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.13 176953.3_32929001_2 - 2e-18 66.7 0.0 5.5e-18 65.3 0.0 1.8 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT PF00533.24 176953.3_32929001_2 - 1.3e-17 63.8 0.0 3.9e-09 36.7 0.0 4.0 4 0 0 4 4 4 2 BRCA1 C Terminus (BRCT) domain DNA_ligase_IV PF11411.6 176953.3_32929001_2 - 4.7e-17 61.7 0.4 8.7e-17 60.8 0.4 1.5 1 0 0 1 1 1 1 DNA ligase IV BRCT_2 PF16589.3 176953.3_32929001_2 - 8.6e-15 54.8 0.0 1.2e-09 38.3 0.0 2.7 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain RNA_ligase PF09414.8 176953.3_32929001_2 - 3.3e-09 37.1 0.1 5.7e-09 36.3 0.1 1.4 1 0 0 1 1 1 1 RNA ligase mRNA_cap_enzyme PF01331.17 176953.3_32929001_2 - 0.036 13.8 0.6 0.65 9.7 0.6 2.4 1 1 0 1 1 1 0 mRNA capping enzyme, catalytic domain Aminotran_1_2 PF00155.19 213928.1_49826001_2 - 4.2e-95 318.9 0.0 5e-95 318.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II PPARgamma_N PF12577.6 214379.1_49824001_2 - 1.5e-32 111.9 1.0 6.6e-32 109.9 1.6 1.8 2 0 0 2 2 2 1 PPAR gamma N-terminal region zf-C4 PF00105.16 214379.1_49824001_2 - 2.1e-27 95.2 15.0 3.5e-27 94.5 15.0 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 214379.1_49824001_2 - 1.1e-16 60.9 0.1 2.8e-16 59.6 0.1 1.7 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Tmemb_55A PF09788.7 214379.1_49824001_2 - 0.04 12.9 3.3 0.065 12.2 3.3 1.2 1 0 0 1 1 1 0 Transmembrane protein 55A Thyroglobulin_1 PF00086.16 001123129.1_49822001_1 - 7.6e-20 70.2 1.1 7.6e-20 70.2 1.1 2.3 2 0 0 2 2 2 1 Thyroglobulin type-1 repeat IGFBP PF00219.16 001123129.1_49822001_1 - 7.7e-10 39.1 21.2 7.7e-10 39.1 21.2 3.0 3 0 0 3 3 3 1 Insulin-like growth factor binding protein OATP PF03137.18 001145946.1_26227001_2 - 2e-180 600.6 15.2 2.9e-180 600.0 15.2 1.3 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 001145946.1_26227001_2 - 1.4e-21 76.6 22.4 3.4e-19 68.9 2.6 3.6 4 0 0 4 4 4 3 Major Facilitator Superfamily Kazal_2 PF07648.13 001145946.1_26227001_2 - 9.6e-11 41.6 4.2 3.2e-10 39.9 4.2 2.0 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 001145946.1_26227001_2 - 0.014 15.3 8.9 0.057 13.3 8.9 2.1 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain AhpC-TSA_2 PF13911.4 001113441.1_49822001_1 - 8e-23 80.6 0.0 1.1e-22 80.2 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.19 001113441.1_49822001_1 - 0.0046 16.7 0.0 0.0083 15.9 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family TACI-CRD2 PF09305.8 001113441.1_49822001_1 - 0.14 12.0 1.5 0.27 11.2 1.5 1.5 1 0 0 1 1 1 0 TACI, cysteine-rich domain Dynamin_M PF01031.18 001009753.1_39525001_2 - 5.6e-78 261.9 14.4 8.9e-78 261.2 14.4 1.3 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.21 001009753.1_39525001_2 - 4.3e-50 169.9 2.6 1.1e-49 168.6 0.0 2.6 2 0 0 2 2 2 1 Dynamin family GED PF02212.16 001009753.1_39525001_2 - 3e-25 88.1 0.5 9.4e-25 86.5 0.5 1.9 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.21 001009753.1_39525001_2 - 0.00044 20.2 1.5 0.0014 18.6 0.1 2.6 2 2 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.25 001009753.1_39525001_2 - 0.012 16.0 2.9 0.054 13.9 0.0 2.8 3 1 0 3 3 3 0 ABC transporter AAA_21 PF13304.4 001009753.1_39525001_2 - 0.013 15.2 1.6 0.034 13.8 0.0 2.4 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 001009753.1_39525001_2 - 0.03 13.9 0.1 0.064 12.9 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DCP2 PF05026.11 001009753.1_39525001_2 - 0.13 12.5 0.6 1.6 9.0 0.0 2.7 2 0 0 2 2 2 0 Dcp2, box A domain AAA_16 PF13191.4 001009753.1_39525001_2 - 0.23 11.7 3.7 1.2 9.4 0.0 3.0 3 2 1 4 4 4 0 AAA ATPase domain AAA_23 PF13476.4 001009753.1_39525001_2 - 0.76 10.1 21.7 4.1 7.7 10.8 3.3 3 0 0 3 3 3 0 AAA domain PROL5-SMR PF15621.4 213811.1_49822001_1 - 0.0014 18.9 2.0 0.0034 17.7 0.7 2.1 2 0 0 2 2 2 1 Proline-rich submaxillary gland androgen-regulated family Lipid_DES PF08557.8 213811.1_49822001_3 - 0.044 13.2 0.6 0.081 12.3 0.6 1.4 1 0 0 1 1 1 0 Sphingolipid Delta4-desaturase (DES) Tfb2 PF03849.12 001517.4_26224001_1 - 8.2e-137 455.8 0.0 1.1e-136 455.4 0.0 1.1 1 0 0 1 1 1 1 Transcription factor Tfb2 Helicase_C_3 PF13625.4 001517.4_26224001_1 - 1.4e-05 25.1 0.1 8.9e-05 22.5 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Trypsin PF00089.24 001106041.1_45723001_2 - 1.4e-65 221.1 0.0 1.7e-65 220.8 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.4 001106041.1_45723001_2 - 9.2e-08 33.0 0.1 1.4e-07 32.3 0.1 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.9 001106041.1_45723001_2 - 0.0021 18.3 0.0 0.0044 17.3 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Arf PF00025.19 001031785.1_49822001_1 - 2.3e-72 241.9 0.0 2.6e-72 241.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.11 001031785.1_49822001_1 - 1.6e-14 54.0 0.0 2.2e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.18 001031785.1_49822001_1 - 2.1e-14 53.3 0.6 1.2e-08 34.4 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.8 001031785.1_49822001_1 - 2.4e-14 53.0 0.0 2.8e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.20 001031785.1_49822001_1 - 1.6e-13 50.4 0.0 1.9e-13 50.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.10 001031785.1_49822001_1 - 9e-13 48.0 0.0 1.1e-12 47.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001031785.1_49822001_1 - 1.4e-08 34.7 0.0 2e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.25 001031785.1_49822001_1 - 5.1e-05 22.8 0.0 0.0016 17.9 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA PF00004.27 001031785.1_49822001_1 - 0.00078 19.7 0.0 0.0011 19.3 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.7 001031785.1_49822001_1 - 0.0059 16.2 0.0 0.012 15.2 0.0 1.5 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.4 001031785.1_49822001_1 - 0.0063 16.9 0.0 0.0097 16.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain cobW PF02492.17 001031785.1_49822001_1 - 0.0079 15.7 0.1 0.99 8.8 0.0 2.1 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain DUF258 PF03193.14 001031785.1_49822001_1 - 0.024 14.4 0.1 4.8 6.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_14 PF13173.4 001031785.1_49822001_1 - 0.025 14.5 0.0 0.054 13.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain NACHT PF05729.10 001031785.1_49822001_1 - 0.038 13.8 0.0 6.1 6.6 0.0 2.2 2 0 0 2 2 2 0 NACHT domain ArgK PF03308.14 001031785.1_49822001_1 - 0.038 12.8 0.0 1.5 7.6 0.0 2.5 2 1 0 2 2 2 0 ArgK protein FeoB_N PF02421.16 001031785.1_49822001_1 - 0.045 13.1 0.1 0.16 11.4 0.1 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B Mre11_DNA_bind PF04152.12 022279.1_45725001_1 - 9.8e-49 165.8 0.3 9.8e-49 165.8 0.3 2.2 2 0 0 2 2 2 1 Mre11 DNA-binding presumed domain Metallophos PF00149.26 022279.1_45725001_1 - 4.4e-16 59.9 0.7 8.3e-16 59.0 0.7 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Spore_III_AB PF09548.8 022279.1_45725001_1 - 1.1 9.2 3.1 2.4 8.1 3.1 1.5 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) Peptidase_S9 PF00326.19 001163624.1_32927001_1 - 8.2e-33 113.5 0.0 1.3e-32 112.9 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S9_N PF02897.13 001163624.1_32927001_1 - 7.2e-27 94.1 0.4 1.1e-26 93.5 0.4 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain 7tm_2 PF00002.22 001164737.1_26228001_1 - 3.1e-79 265.6 26.2 5.4e-78 261.5 26.2 2.2 1 1 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 001164737.1_26228001_1 - 1.5e-18 66.7 7.2 3.2e-18 65.6 7.2 1.6 1 0 0 1 1 1 1 Hormone receptor domain Lipocalin PF00061.21 001002817.1_49822001_2 - 4e-26 91.8 1.1 4.8e-26 91.6 1.1 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.4 001002817.1_49822001_2 - 1.7e-07 31.1 1.3 2.4e-07 30.6 1.3 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Insulin PF00049.16 001109772.1_49821001_3 - 1.2e-23 83.8 0.8 1.6e-23 83.4 0.8 1.2 1 0 0 1 1 1 1 Insulin/IGF/Relaxin family Ins_beta PF03488.12 001109772.1_49821001_3 - 0.64 10.0 0.2 0.64 10.0 0.2 2.5 3 0 0 3 3 3 0 Nematode insulin-related peptide beta type Cobalamin_bind PF01122.17 001131351.1_43525001_1 - 2.4e-113 378.1 0.0 2.4e-113 378.1 0.0 1.6 2 0 0 2 2 2 1 Eukaryotic cobalamin-binding protein DUF4430 PF14478.4 001131351.1_43525001_1 - 2.7e-05 24.5 0.0 6.8e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4430) EOS1 PF12326.6 001131351.1_43525001_1 - 1.7 8.4 4.9 2.5 7.9 4.9 1.2 1 0 0 1 1 1 0 N-glycosylation protein RNase_H2_suC PF08615.9 001131351.1_43525001_2 - 0.018 15.1 0.6 0.029 14.4 0.6 1.3 1 0 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) RNA_pol_Rpc4 PF05132.12 001131351.1_43525001_2 - 0.86 9.9 16.3 1.5 9.1 16.3 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 EIIBC-GUT_N PF03612.12 001131351.1_43525001_2 - 1.9 8.1 10.5 2.6 7.6 10.5 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus MIP-T3 PF10243.7 001131351.1_43525001_2 - 2.7 6.5 33.4 3.3 6.2 33.4 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Rxt3 PF08642.8 001131351.1_43525001_2 - 4.1 8.1 9.4 6.5 7.4 9.4 1.2 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 EOS1 PF12326.6 001131351.1_43525001_3 - 3.5 7.4 6.0 4.7 7.0 6.0 1.1 1 0 0 1 1 1 0 N-glycosylation protein Rxt3 PF08642.8 001131351.1_43525001_3 - 5.6 7.6 7.9 9.8 6.8 7.9 1.3 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 SUI1 PF01253.20 001001635.1_49822001_1 - 1.2e-28 99.3 1.0 2.1e-28 98.5 1.0 1.4 1 0 0 1 1 1 1 Translation initiation factor SUI1 COMM_domain PF07258.12 198732.2_45722001_1 - 4.1e-17 61.9 0.1 6.9e-17 61.2 0.1 1.4 1 0 0 1 1 1 1 COMM domain Aminotran_1_2 PF00155.19 213927.1_49825001_3 - 7.1e-95 318.1 0.0 8.5e-95 317.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cystatin PF00031.19 012898.4_45723001_2 - 1.2e-21 76.6 0.1 2.7e-17 62.7 0.1 2.3 2 0 0 2 2 2 2 Cystatin domain Cathelicidins PF00666.15 012898.4_45723001_2 - 0.11 12.7 2.1 0.15 12.2 0.1 2.1 2 1 0 2 2 2 0 Cathelicidin Ala_racemase_N PF01168.18 001133397.1_43526001_3 - 1.1e-19 70.8 0.0 1.6e-19 70.3 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Ldh_1_C PF02866.16 213874.1_49823001_1 - 1.8e-45 154.7 0.0 5.7e-45 153.1 0.0 1.7 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.21 213874.1_49823001_1 - 9e-39 132.6 0.2 1.8e-38 131.7 0.2 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain DUF4809 PF16067.3 213874.1_49823001_1 - 0.1 12.6 0.1 0.53 10.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4809) Pkinase PF00069.23 001082629.1_37923001_1 - 1e-62 211.8 0.0 1.3e-62 211.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 001082629.1_37923001_1 - 6.2e-35 120.6 0.0 4.8e-33 114.4 0.0 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase Seadorna_VP7 PF07387.9 001082629.1_37923001_1 - 0.015 14.3 0.0 0.023 13.6 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kinase-like PF14531.4 001082629.1_37923001_1 - 0.019 14.2 0.0 0.046 12.9 0.0 1.6 1 0 0 1 1 1 0 Kinase-like DUF3216 PF11505.6 001082629.1_37923001_1 - 0.048 13.8 0.3 0.11 12.7 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3216) NAD_binding_6 PF08030.10 001082629.1_37923001_1 - 0.18 11.8 0.0 0.3 11.1 0.0 1.3 1 0 0 1 1 1 0 Ferric reductase NAD binding domain Glyoxalase PF00903.23 001083496.1_06525001_3 - 5e-22 78.3 0.0 7e-22 77.9 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.4 001083496.1_06525001_3 - 2.8e-07 30.7 0.0 5.4e-07 29.8 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily T4_deiodinase PF00837.15 001001627.1_49822001_1 - 2.2e-103 344.5 0.0 2.6e-103 344.3 0.0 1.0 1 0 0 1 1 1 1 Iodothyronine deiodinase Defensin_beta_2 PF13841.4 001129769.1_39721001_1 - 1.8e-09 37.8 8.6 2.3e-09 37.4 8.6 1.2 1 0 0 1 1 1 1 Beta defensin PPARgamma_N PF12577.6 001082148.1_37925001_1 - 1.7e-31 108.5 0.7 4.4e-31 107.2 0.7 1.7 1 0 0 1 1 1 1 PPAR gamma N-terminal region zf-C4 PF00105.16 001082148.1_37925001_1 - 6.6e-27 93.6 13.8 1.3e-26 92.7 13.8 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001082148.1_37925001_1 - 3e-16 59.5 0.4 7.7e-16 58.2 0.4 1.7 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Tmemb_55A PF09788.7 001082148.1_37925001_1 - 0.0068 15.4 3.0 0.012 14.6 3.0 1.3 1 0 0 1 1 1 1 Transmembrane protein 55A Miff PF05644.9 213797.1_49822001_3 - 6.8e-09 35.6 1.8 8.8e-09 35.3 1.5 1.3 1 1 0 1 1 1 1 Mitochondrial and peroxisomal fission factor Mff EHN PF06441.10 214355.1_49824001_2 - 7.9e-35 119.2 0.2 1.5e-34 118.4 0.2 1.5 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.18 214355.1_49824001_2 - 4.5e-23 82.1 0.0 7.9e-23 81.3 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.5 214355.1_49824001_2 - 0.0028 18.2 0.3 0.018 15.5 0.0 2.4 2 1 0 2 2 2 1 Alpha/beta hydrolase family Na_K-ATPase PF00287.16 214132.1_49823001_1 - 1.4e-92 309.7 0.2 2.2e-92 309.1 0.2 1.3 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain CbtA PF09490.8 214132.1_49823001_1 - 0.096 12.3 0.0 0.14 11.8 0.0 1.1 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) RNA_polI_A34 PF08208.9 214132.1_49823001_1 - 0.12 12.3 3.4 0.2 11.6 3.4 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Nop14 PF04147.10 214132.1_49823001_1 - 0.22 9.6 7.9 0.3 9.1 7.9 1.1 1 0 0 1 1 1 0 Nop14-like family TFB6 PF17110.3 214132.1_49823001_1 - 0.23 11.1 4.6 0.39 10.3 4.6 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Paf1 PF03985.11 214132.1_49823001_1 - 1.1 8.1 10.8 1.5 7.6 10.8 1.1 1 0 0 1 1 1 0 Paf1 DNA_pol_phi PF04931.11 214132.1_49823001_1 - 1.5 6.7 10.8 2.1 6.3 10.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi ELM2 PF01448.22 214132.1_49823001_1 - 2.9 8.6 9.2 0.16 12.6 3.8 1.7 2 0 0 2 2 2 0 ELM2 domain Peptidase_M28 PF04389.15 001081913.1_21025001_1 - 3.2e-13 49.7 0.0 9.9e-13 48.1 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M28 TFR_dimer PF04253.13 001081913.1_21025001_1 - 1e-09 38.4 0.3 3.4e-09 36.8 0.1 2.1 2 1 0 2 2 2 1 Transferrin receptor-like dimerisation domain PA PF02225.20 001081913.1_21025001_1 - 5.1e-09 36.0 0.0 1.3e-08 34.7 0.0 1.7 1 0 0 1 1 1 1 PA domain Prominin PF05478.9 001081913.1_21025001_1 - 0.23 9.2 0.1 0.38 8.5 0.1 1.2 1 0 0 1 1 1 0 Prominin DUF1510 PF07423.9 001103298.2_06525001_1 - 0.009 15.3 22.8 0.011 15.0 22.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) V_ATPase_I PF01496.17 001103298.2_06525001_1 - 1.7 6.3 23.7 2.3 5.8 23.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FAM176 PF14851.4 001103298.2_06525001_1 - 2.7 7.5 8.3 4 7.0 8.3 1.3 1 0 0 1 1 1 0 FAM176 family CLN3 PF02487.15 001103298.2_06525001_1 - 3.8 6.3 13.1 4.8 6.0 13.1 1.1 1 0 0 1 1 1 0 CLN3 protein RNA_pol_Rpc4 PF05132.12 001103298.2_06525001_1 - 6.1 7.2 24.8 10 6.4 24.8 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 RNA_pol_Rpc4 PF05132.12 001103298.2_06525001_2 - 0.071 13.4 18.1 0.11 12.8 18.1 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 RSRP PF17069.3 001103298.2_06525001_3 - 1.7e-78 264.1 76.3 3.9e-69 233.4 71.5 2.9 3 0 0 3 3 3 2 Arginine/Serine-Rich protein 1 DUF1510 PF07423.9 001103298.2_06525001_3 - 5.4 6.3 29.8 9.2 5.5 29.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Oest_recep PF02159.13 214220.1_49824001_1 - 3.5e-70 234.8 4.7 3.5e-70 234.8 4.7 1.7 2 0 0 2 2 2 1 Oestrogen receptor Hormone_recep PF00104.28 214220.1_49824001_1 - 3e-33 115.0 4.0 4.5e-33 114.5 4.0 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 214220.1_49824001_1 - 1.5e-31 108.5 13.9 2.4e-31 107.9 13.9 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) ESR1_C PF12743.5 214220.1_49824001_1 - 7.2e-24 83.2 3.4 1.4e-23 82.2 3.4 1.5 1 0 0 1 1 1 1 Oestrogen-type nuclear receptor final C-terminal Jiv90 PF14901.4 214220.1_49824001_1 - 0.3 11.2 4.9 1.2 9.2 4.5 2.1 2 0 0 2 2 2 0 Cleavage inducing molecular chaperone UDPGT PF00201.16 001089322.1_37925001_2 - 8.5e-237 786.7 0.1 1e-236 786.5 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001089322.1_37925001_2 - 1e-06 28.7 0.0 1.9e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain AA_permease_2 PF13520.4 001082682.1_37929001_3 - 3.4e-67 227.0 38.5 4.7e-67 226.5 38.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.19 001082682.1_37929001_3 - 1.5e-36 125.9 34.3 2.3e-36 125.3 34.3 1.2 1 0 0 1 1 1 1 Amino acid permease RRM_1 PF00076.20 213963.2_49825001_3 - 1.4e-07 31.1 0.0 2.8e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Tox-ODYAM1 PF15642.4 213963.2_49825001_3 - 0.25 10.1 1.5 0.4 9.5 1.5 1.2 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus MACPF PF01823.17 017330.2_45724001_2 - 3e-43 148.2 0.0 3e-43 148.2 0.0 1.7 2 0 0 2 2 2 1 MAC/Perforin domain C2 PF00168.28 017330.2_45724001_2 - 3.3e-09 36.8 0.0 9e-09 35.4 0.0 1.7 1 0 0 1 1 1 1 C2 domain Ank_2 PF12796.5 001005150.1_49822001_1 - 6.7e-29 100.2 0.5 4.4e-12 46.3 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.28 001005150.1_49822001_1 - 4e-28 96.5 7.0 2.8e-07 30.6 0.2 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.4 001005150.1_49822001_1 - 1.7e-24 83.1 4.3 5.3e-06 26.2 0.1 5.2 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.4 001005150.1_49822001_1 - 5e-24 83.9 8.7 2.2e-10 40.5 0.1 3.8 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.4 001005150.1_49822001_1 - 4.4e-21 74.8 0.3 2.5e-09 37.3 0.3 4.6 3 2 2 5 5 5 4 Ankyrin repeats (many copies) OATP PF03137.18 053441.1_45726001_3 - 4.5e-179 596.1 12.9 5.7e-179 595.8 12.9 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.14 053441.1_45726001_3 - 1.5e-21 76.6 17.9 6.2e-18 64.7 4.8 3.1 3 0 0 3 3 3 3 Major Facilitator Superfamily Kazal_2 PF07648.13 053441.1_45726001_3 - 1.7e-09 37.6 3.8 3.8e-09 36.5 3.8 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.19 053441.1_45726001_3 - 0.00017 21.4 5.3 0.00045 20.1 5.3 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Pkinase_Tyr PF07714.15 001114147.1_21029001_1 - 1.3e-92 309.6 0.0 2e-92 309.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Sema PF01403.17 001114147.1_21029001_1 - 3e-61 207.3 4.1 4.7e-61 206.7 4.1 1.2 1 0 0 1 1 1 1 Sema domain TIG PF01833.22 001114147.1_21029001_1 - 9.7e-41 137.6 16.8 5e-15 55.2 1.3 4.8 4 0 0 4 4 4 4 IPT/TIG domain Pkinase PF00069.23 001114147.1_21029001_1 - 6.9e-40 136.9 0.0 1.2e-39 136.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain PSI PF01437.23 001114147.1_21029001_1 - 3.4e-05 24.1 15.3 3.4e-05 24.1 15.3 2.4 2 0 0 2 2 2 1 Plexin repeat Kinase-like PF14531.4 001114147.1_21029001_1 - 0.00032 20.0 0.0 0.00055 19.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like PSI_integrin PF17205.1 001114147.1_21029001_1 - 1.1 9.0 10.8 4.8 7.0 10.8 2.1 1 0 0 1 1 1 0 Integrin plexin domain SH3_2 PF07653.15 019302.1_45723001_1 - 8.2e-24 82.9 2.1 2.5e-11 42.9 0.0 2.7 3 0 0 3 3 3 2 Variant SH3 domain SH2 PF00017.22 019302.1_45723001_1 - 6.3e-19 67.7 0.0 1.3e-18 66.7 0.0 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.26 019302.1_45723001_1 - 1.4e-17 62.8 4.8 4e-15 55.0 0.2 2.6 3 0 0 3 3 3 2 SH3 domain SH3_9 PF14604.4 019302.1_45723001_1 - 7.6e-14 51.2 0.1 1.5e-09 37.4 0.1 2.6 2 0 0 2 2 2 2 Variant SH3 domain WW PF00397.24 001097581.1_45725001_1 - 9.1e-14 51.0 17.7 1.1e-09 37.9 3.9 2.9 3 0 0 3 3 3 2 WW domain EBP50_C PF09007.9 023449.3_32924001_2 - 9.6e-29 100.9 4.5 4.2e-18 66.5 1.2 2.4 1 1 1 2 2 2 2 EBP50, C-terminal PDZ PF00595.22 023449.3_32924001_2 - 2.7e-15 56.3 0.0 4.3e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.4 023449.3_32924001_2 - 6.3e-06 26.3 0.0 1.2e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Dynamin_M PF01031.18 001078652.1_39526001_3 - 2.1e-81 273.1 12.8 2.1e-81 273.1 12.8 1.9 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.21 001078652.1_39526001_3 - 1.5e-48 164.9 0.9 3.1e-48 163.9 0.1 2.0 2 0 0 2 2 2 1 Dynamin family GED PF02212.16 001078652.1_39526001_3 - 3.8e-26 90.9 1.3 1.1e-25 89.4 1.3 1.9 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.21 001078652.1_39526001_3 - 0.00026 20.9 0.1 0.00088 19.2 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_21 PF13304.4 001078652.1_39526001_3 - 0.021 14.5 0.4 0.064 12.9 0.1 1.9 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 001078652.1_39526001_3 - 0.034 13.7 0.1 0.075 12.6 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.4 001078652.1_39526001_3 - 0.11 12.7 0.1 0.33 11.2 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain 7tm_2 PF00002.22 214382.1_49825001_1 - 3.4e-92 308.0 14.3 4.5e-92 307.6 14.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.20 214382.1_49825001_1 - 4.8e-19 68.3 2.5 1.3e-18 66.8 2.5 1.8 1 0 0 1 1 1 1 Hormone receptor domain MRP-S26 PF14943.4 207207.1_32922001_2 - 8.7e-55 185.1 13.9 1.2e-54 184.6 13.9 1.2 1 0 0 1 1 1 1 Mitochondrial ribosome subunit S26 Histone_H2A_C PF16211.3 207207.1_32922001_2 - 0.19 11.3 4.0 0.39 10.4 4.0 1.5 1 0 0 1 1 1 0 C-terminus of histone H2A S_100 PF01023.17 031114.1_45722001_1 - 2.2e-14 52.7 0.8 3.7e-14 52.0 0.8 1.4 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.4 031114.1_45722001_1 - 6.9e-06 26.3 0.1 9.9e-06 25.8 0.1 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.30 031114.1_45722001_1 - 0.00049 19.3 0.2 0.0063 15.9 0.0 2.3 2 0 0 2 2 2 1 EF hand EFhand_Ca_insen PF08726.8 031114.1_45722001_1 - 0.0014 18.5 0.1 0.0028 17.6 0.1 1.6 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_8 PF13833.4 031114.1_45722001_1 - 0.018 14.6 0.2 0.054 13.1 0.2 1.8 1 1 0 1 1 1 0 EF-hand domain pair Metallophos PF00149.26 214184.2_49826001_2 - 2.1e-38 132.8 0.1 2.6e-38 132.4 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.3 214184.2_49826001_2 - 6.1e-20 71.3 0.5 1.2e-19 70.3 0.5 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain FBPase PF00316.18 213979.1_49823001_1 - 9.7e-81 269.7 0.2 1.3e-80 269.3 0.2 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.23 213979.1_49823001_1 - 0.00016 21.2 0.0 0.00026 20.5 0.0 1.3 1 0 0 1 1 1 1 Inositol monophosphatase family ABC2_membrane PF01061.22 213979.1_49823001_1 - 0.064 12.5 0.0 0.9 8.8 0.0 2.1 2 0 0 2 2 2 0 ABC-2 type transporter Plexin_cytopl PF08337.10 001107581.2_45729001_3 - 2.5e-251 835.1 1.1 3.1e-251 834.8 1.1 1.1 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Sema PF01403.17 001107581.2_45729001_3 - 4.5e-72 243.0 0.0 6.5e-72 242.5 0.0 1.2 1 0 0 1 1 1 1 Sema domain TIG PF01833.22 001107581.2_45729001_3 - 4.2e-42 142.0 9.5 1.7e-10 40.7 0.4 5.7 5 0 0 5 5 5 4 IPT/TIG domain PSI PF01437.23 001107581.2_45729001_3 - 2.6e-18 66.1 57.6 2.6e-08 34.2 12.9 3.9 3 0 0 3 3 3 3 Plexin repeat Tubulin PF00091.23 001044544.1_49824001_1 - 7.1e-69 231.8 0.0 9.5e-69 231.4 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.15 001044544.1_49824001_1 - 2.3e-51 173.1 0.0 3.6e-51 172.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.4 001044544.1_49824001_1 - 0.0018 17.9 0.0 0.0033 17.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Peptidase_M28 PF04389.15 001009312.1_22425001_1 - 4.6e-13 49.2 0.0 7.8e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.20 001009312.1_22425001_1 - 7.5e-10 38.7 0.0 1.9e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 PA domain TFR_dimer PF04253.13 001009312.1_22425001_1 - 9.8e-10 38.5 0.4 7.7e-09 35.6 0.1 2.4 2 0 0 2 2 2 1 Transferrin receptor-like dimerisation domain UN_NPL4 PF11543.6 001009312.1_22425001_1 - 0.067 13.6 0.0 2.4 8.6 0.0 2.9 2 0 0 2 2 2 0 Nuclear pore localisation protein NPL4 Uso1_p115_head PF04869.12 001009312.1_22425001_1 - 0.096 11.7 0.2 0.16 11.0 0.2 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, head region Herpes_heli_pri PF05774.9 001009312.1_22425001_1 - 0.16 12.0 0.0 0.4 10.8 0.0 1.6 1 0 0 1 1 1 0 Herpesvirus helicase-primase complex component Feld-I_B PF09252.8 001048154.1_22421001_2 - 2e-28 98.0 0.0 2.9e-28 97.5 0.0 1.2 1 0 0 1 1 1 1 Allergen Fel d I-B chain LBP_BPI_CETP_C PF02886.15 011125.2_32924001_2 - 2.8e-71 239.6 0.0 3.9e-71 239.1 0.0 1.2 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.23 011125.2_32924001_2 - 4.6e-35 120.5 0.1 1.7e-34 118.7 0.0 1.8 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain RRM_1 PF00076.20 001077222.1_49822001_1 - 2.2e-29 100.9 1.3 1.1e-14 53.8 0.1 2.6 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.3 001077222.1_49822001_1 - 3.8e-08 32.9 0.0 0.00034 20.3 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_5 PF13893.4 001077222.1_49822001_1 - 6.2e-08 32.2 0.0 0.0049 16.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4523 PF15023.4 001077222.1_49822001_1 - 0.0042 16.8 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF4523) Nup35_RRM_2 PF14605.4 001077222.1_49822001_1 - 0.18 11.6 0.0 2.3 8.1 0.0 2.2 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif APP_E2 PF12925.5 214372.1_49827001_3 - 5.1e-74 248.0 20.3 8.6e-74 247.2 20.3 1.4 1 0 0 1 1 1 1 E2 domain of amyloid precursor protein APP_N PF02177.14 214372.1_49827001_3 - 1.2e-44 150.6 1.1 1.2e-44 150.6 1.1 2.3 2 0 0 2 2 2 1 Amyloid A4 N-terminal heparin-binding Beta-APP PF03494.11 214372.1_49827001_3 - 8.6e-27 92.6 1.7 1.5e-26 91.8 1.7 1.4 1 0 0 1 1 1 1 Beta-amyloid peptide (beta-APP) APP_Cu_bd PF12924.5 214372.1_49827001_3 - 4.9e-26 91.1 8.5 2.4e-25 88.9 4.7 2.9 2 0 0 2 2 2 1 Copper-binding of amyloid precursor, CuBD APP_amyloid PF10515.7 214372.1_49827001_3 - 1.6e-25 89.3 0.3 8.6e-25 86.9 0.3 2.4 1 0 0 1 1 1 1 beta-amyloid precursor protein C-terminus Kunitz_BPTI PF00014.21 214372.1_49827001_3 - 1.4e-19 69.9 6.5 3.2e-19 68.7 6.5 1.7 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Roughex PF06020.9 214372.1_49827001_3 - 0.59 9.0 9.3 1.2 8.0 9.3 1.5 1 0 0 1 1 1 0 Drosophila roughex protein PilJ PF13675.4 214372.1_49827001_3 - 2.6 8.0 7.3 0.42 10.6 2.0 2.3 2 1 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term S_100 PF01023.17 001004045.1_49821001_3 - 2.3e-16 59.1 0.8 2.7e-16 58.9 0.1 1.5 2 0 0 2 2 2 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.30 001004045.1_49821001_3 - 4.2e-08 32.0 2.3 1.2e-06 27.5 0.5 2.3 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.4 001004045.1_49821001_3 - 8e-07 29.3 0.1 1.2e-06 28.7 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.4 001004045.1_49821001_3 - 2e-05 24.0 1.8 0.017 14.9 0.5 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.4 001004045.1_49821001_3 - 0.00037 20.1 0.4 0.0046 16.6 0.1 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.4 001004045.1_49821001_3 - 0.00038 19.7 4.4 0.00075 18.8 1.2 2.3 2 0 0 2 2 2 1 EF hand EF-hand_4 PF12763.5 001004045.1_49821001_3 - 0.013 15.3 0.4 0.02 14.7 0.4 1.3 1 1 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Pkinase PF00069.23 214266.1_49825001_1 - 1.9e-72 243.7 0.0 3e-72 243.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.15 214266.1_49825001_1 - 5e-41 140.6 0.0 1.2e-40 139.3 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase AdenylateSensor PF16579.3 214266.1_49825001_1 - 5.2e-14 52.6 0.0 1.7e-13 50.9 0.0 1.9 1 0 0 1 1 1 1 Adenylate sensor of SNF1-like protein kinase Kinase-like PF14531.4 214266.1_49825001_1 - 1.8e-06 27.4 0.0 2.6e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.20 214266.1_49825001_1 - 0.0014 18.1 0.4 0.0039 16.7 0.4 1.7 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.12 214266.1_49825001_1 - 0.0022 17.2 0.1 0.0042 16.3 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.21 214266.1_49825001_1 - 0.045 13.5 0.0 0.083 12.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family YukC PF10140.7 214266.1_49825001_1 - 0.16 10.6 0.0 0.24 10.1 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC zf-RING_UBOX PF13445.4 001112632.1_40423001_1 - 5.7e-13 48.5 6.1 6.4e-13 48.4 3.9 2.4 1 1 1 2 2 2 1 RING-type zinc-finger SPRY PF00622.26 001112632.1_40423001_1 - 9.3e-11 41.8 0.3 2.2e-10 40.6 0.3 1.6 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_4 PF15227.4 001112632.1_40423001_1 - 9.7e-11 41.5 8.8 9.7e-11 41.5 8.8 2.0 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.23 001112632.1_40423001_1 - 8.3e-10 38.2 8.2 2.1e-09 36.9 8.2 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.4 001112632.1_40423001_1 - 2.3e-08 33.6 8.7 9.9e-08 31.6 8.8 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.4 001112632.1_40423001_1 - 6.7e-08 32.5 8.0 6.7e-08 32.5 8.0 2.0 2 0 0 2 2 1 1 Ring finger domain zf-B_box PF00643.22 001112632.1_40423001_1 - 7.6e-08 32.3 3.6 7.6e-08 32.3 3.6 3.0 3 1 0 3 3 2 1 B-box zinc finger zf-C3HC4_3 PF13920.4 001112632.1_40423001_1 - 1.3e-07 31.2 6.1 1.3e-07 31.2 6.1 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.4 001112632.1_40423001_1 - 2e-07 30.7 6.2 2e-07 30.7 6.2 2.1 2 0 0 2 2 2 1 zinc-RING finger domain U-box PF04564.13 001112632.1_40423001_1 - 2.7e-05 24.1 0.0 6.5e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 U-box domain TMF_TATA_bd PF12325.6 001112632.1_40423001_1 - 0.00052 20.1 1.6 0.00052 20.1 1.6 2.4 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding zf-RING_10 PF16685.3 001112632.1_40423001_1 - 0.021 14.8 4.3 0.021 14.8 4.3 2.0 2 0 0 2 2 1 0 zinc RING finger of MSL2 Prok-RING_4 PF14447.4 001112632.1_40423001_1 - 0.021 14.6 9.5 0.021 14.6 9.5 2.7 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-Nse PF11789.6 001112632.1_40423001_1 - 0.025 14.3 4.8 0.066 12.9 4.8 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Baculo_IE-1 PF05290.9 001112632.1_40423001_1 - 0.068 13.0 3.8 0.051 13.4 1.4 2.1 2 0 0 2 2 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_6 PF14835.4 001112632.1_40423001_1 - 0.079 12.7 4.7 0.12 12.2 3.4 2.0 2 1 0 2 2 1 0 zf-RING of BARD1-type protein AAA_11 PF13086.4 001112632.1_40423001_1 - 0.34 10.5 4.8 0.5 9.9 4.8 1.2 1 0 0 1 1 1 0 AAA domain zf-RING_11 PF17123.3 001112632.1_40423001_1 - 0.4 10.3 4.8 1.6 8.4 4.8 2.2 1 0 0 1 1 1 0 RING-like zinc finger zf-UDP PF14569.4 001112632.1_40423001_1 - 0.49 10.4 4.0 0.52 10.3 1.1 2.4 2 0 0 2 2 2 0 Zinc-binding RING-finger zf-RING_4 PF14570.4 001112632.1_40423001_1 - 0.69 9.6 8.3 5.7 6.6 8.6 2.4 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.5 001112632.1_40423001_1 - 1.2 9.3 10.6 0.53 10.5 6.7 2.4 2 1 0 2 2 2 0 RING-H2 zinc finger domain LsmAD PF06741.11 001112632.1_40423001_1 - 1.6 9.2 4.6 1.1 9.8 2.4 1.9 1 1 0 1 1 1 0 LsmAD domain DUF4407 PF14362.4 001112632.1_40423001_1 - 3.2 6.9 6.3 4.6 6.4 6.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CaM-KIIN PF15170.4 173337.1_45721001_1 - 4.3e-46 154.8 0.0 5.6e-46 154.5 0.0 1.1 1 0 0 1 1 1 1 Calcium/calmodulin-dependent protein kinase II inhibitor PACT_coil_coil PF10495.7 194462.2_32929001_3 - 8.2e-24 83.8 0.1 8.2e-24 83.8 0.1 7.3 7 2 0 7 7 7 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein FXMR_C2 PF16098.3 194462.2_32929001_3 - 0.46 10.9 4.9 16 5.9 4.0 3.9 2 0 0 2 2 2 0 Fragile X-related mental retardation protein C-terminal region 2 PI3_PI4_kinase PF00454.25 001001983.2_32929001_1 - 2.2e-41 142.2 0.4 3e-28 99.2 0.4 2.9 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.18 001001983.2_32929001_1 - 2.6e-35 121.4 0.0 6.4e-35 120.1 0.0 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Ribosomal_L18_c PF14204.4 001001983.2_32929001_1 - 0.11 13.3 0.2 0.29 11.9 0.2 1.7 1 0 0 1 1 1 0 Ribosomal L18 C-terminal region Ipi1_N PF12333.6 001001983.2_32929001_1 - 0.16 12.5 0.9 2.4 8.7 0.1 3.4 3 1 1 4 4 4 0 Rix1 complex component involved in 60S ribosome maturation RGS PF00615.17 001044600.1_49823001_2 - 4.5e-38 130.0 4.9 6.8e-38 129.4 4.9 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF3915 PF13054.4 178119.3_32929001_1 - 2.1 8.2 4.8 4.5 7.1 4.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) ArfGap PF01412.16 178119.3_32929001_2 - 6.7e-38 129.2 0.0 1.2e-37 128.3 0.0 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Ras PF00071.20 178119.3_32929001_2 - 1.1e-16 60.8 0.0 1.6e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 Ras family Ank_2 PF12796.5 178119.3_32929001_2 - 4.7e-10 39.8 0.1 8.4e-10 39.0 0.1 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) PH PF00169.27 178119.3_32929001_2 - 4.3e-09 36.7 0.1 0.0046 17.3 0.0 2.7 2 0 0 2 2 2 2 PH domain Ank PF00023.28 178119.3_32929001_2 - 4.4e-08 33.1 0.0 4.7e-05 23.5 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.4 178119.3_32929001_2 - 6.8e-08 32.5 0.7 1.4e-07 31.6 0.7 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.4 178119.3_32929001_2 - 3.8e-05 24.0 0.1 0.001 19.5 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.4 178119.3_32929001_2 - 0.00062 19.9 0.1 0.005 17.1 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat PH_6 PF15406.4 178119.3_32929001_2 - 0.0082 16.3 0.1 0.015 15.5 0.1 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain Roc PF08477.11 178119.3_32929001_2 - 0.012 15.7 0.0 0.03 14.4 0.0 1.6 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase PH_11 PF15413.4 178119.3_32929001_2 - 0.11 12.8 1.7 11 6.3 0.3 2.6 2 0 0 2 2 2 0 Pleckstrin homology domain DUF3915 PF13054.4 178119.3_32929001_3 - 0.079 12.8 2.7 0.14 12.0 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) CARD PF00619.19 175362.2_32929001_1 - 1.1e-21 76.6 0.0 3.6e-21 74.9 0.0 2.0 1 0 0 1 1 1 1 Caspase recruitment domain Guanylate_kin PF00625.19 175362.2_32929001_1 - 0.00051 19.7 3.7 0.0061 16.1 0.0 2.5 2 0 0 2 2 2 1 Guanylate kinase PDZ PF00595.22 175362.2_32929001_1 - 0.0007 19.8 0.0 0.0015 18.7 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) TNFR_c6 PF00020.16 214194.1_49823001_1 - 2.9e-13 49.8 49.2 3.3e-05 24.1 0.9 5.2 5 0 0 5 5 5 4 TNFR/NGFR cysteine-rich region Syndecan PF01034.18 214194.1_49823001_1 - 0.16 11.8 0.3 0.3 10.9 0.3 1.3 1 0 0 1 1 1 0 Syndecan domain Endothelin PF00322.15 001009810.1_39523001_1 - 1.1e-23 82.3 13.8 3.9e-21 74.2 3.6 2.6 2 0 0 2 2 2 2 Endothelin family Peptidase_C1 PF00112.21 214302.1_49822001_2 - 2.2e-83 279.5 4.8 2.8e-83 279.2 4.8 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.10 214302.1_49822001_2 - 2.1e-11 43.9 0.2 4.3e-11 43.0 0.2 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.13 214302.1_49822001_2 - 2e-08 33.3 1.1 5.5e-05 22.0 0.6 2.2 2 0 0 2 2 2 2 Peptidase C1-like family AMPK1_CBM PF16561.3 022627.2_45724001_2 - 2.3e-35 120.5 0.1 3.6e-35 119.9 0.1 1.3 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.13 022627.2_45724001_2 - 2.8e-26 91.5 4.1 5e-26 90.7 4.1 1.4 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain CBM_48 PF02922.16 022627.2_45724001_2 - 0.0075 16.5 0.0 0.014 15.6 0.0 1.4 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Ion_trans PF00520.29 001101693.1_37929001_3 - 1.5e-244 806.9 88.2 6.3e-68 228.5 0.6 4.9 5 0 0 5 5 5 4 Ion transport protein GPHH PF16905.3 001101693.1_37929001_3 - 4.7e-36 122.3 0.1 1.4e-35 120.8 0.1 1.9 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.9 001101693.1_37929001_3 - 8.7e-31 105.9 0.5 2.4e-30 104.5 0.5 1.8 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.10 001101693.1_37929001_3 - 9.1e-06 24.5 7.9 9.1e-06 24.5 7.9 9.9 6 4 4 10 10 10 5 Polycystin cation channel KTI12 PF08433.8 029571.2_32924001_2 - 1.3e-106 355.8 0.0 1.6e-106 355.6 0.0 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.4 029571.2_32924001_2 - 6.5e-05 23.0 0.0 0.00015 21.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.4 029571.2_32924001_2 - 0.0055 17.1 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.4 029571.2_32924001_2 - 0.048 13.9 0.6 0.85 9.8 0.4 2.5 2 1 1 3 3 3 0 AAA ATPase domain APS_kinase PF01583.18 029571.2_32924001_2 - 0.1 12.3 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase PIG-F PF06699.9 008838.1_32922001_3 - 2.1e-46 158.3 9.9 2.7e-46 157.9 9.9 1.1 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F Syntaxin_2 PF14523.4 022939.2_45725001_1 - 7.3e-27 93.6 19.2 1e-26 93.1 13.5 2.2 2 0 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.17 022939.2_45725001_1 - 1.6e-19 69.5 1.2 3.5e-19 68.4 1.2 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.23 022939.2_45725001_1 - 6.4e-12 45.4 19.4 9.6e-12 44.9 19.4 1.2 1 0 0 1 1 1 1 Syntaxin IL3 PF02059.13 022939.2_45725001_1 - 0.02 14.9 1.6 0.04 13.9 1.6 1.4 1 0 0 1 1 1 0 Interleukin-3 Synaptobrevin PF00957.19 022939.2_45725001_1 - 0.92 9.2 12.1 0.58 9.9 2.5 2.5 2 0 0 2 2 2 0 Synaptobrevin TIM PF00121.16 009415.2_32924001_1 - 9.6e-84 280.4 0.0 1.2e-83 280.1 0.0 1.1 1 0 0 1 1 1 1 Triosephosphate isomerase DUF4592 PF15262.4 138648.2_32928001_1 - 0.67 10.7 4.1 2 9.2 0.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4592) Lectin_C PF00059.19 138648.2_32928001_2 - 4.7e-14 52.9 0.7 1.1e-13 51.8 0.0 2.0 2 0 0 2 2 2 1 Lectin C-type domain UL45 PF05473.10 138648.2_32928001_2 - 1.7e-05 24.4 0.0 5.5e-05 22.8 0.0 1.9 2 0 0 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like Ly49 PF08391.8 138648.2_32928001_2 - 0.001 19.2 17.0 0.014 15.6 5.2 2.6 2 0 0 2 2 2 2 Ly49-like protein, N-terminal region Snapin_Pallidin PF14712.4 138648.2_32928001_2 - 0.056 13.8 32.2 0.2 12.0 5.1 3.4 1 1 2 3 3 3 0 Snapin/Pallidin HemX PF04375.12 138648.2_32928001_2 - 0.057 12.6 33.6 0.59 9.2 14.9 2.1 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Oleosin PF01277.15 138648.2_32928001_2 - 0.064 12.9 0.0 0.19 11.3 0.0 1.8 1 0 0 1 1 1 0 Oleosin Nup88 PF10168.7 138648.2_32928001_2 - 4.1 4.9 33.9 7.1 4.2 33.9 1.3 1 0 0 1 1 1 0 Nuclear pore component DUF1664 PF07889.10 138648.2_32928001_2 - 4.7 7.1 26.3 1.5 8.7 6.3 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) CRAL_TRIO PF00650.18 029512.2_32929001_3 - 9e-33 113.1 0.0 1.3e-32 112.6 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.13 029512.2_32929001_3 - 4e-07 30.0 0.9 8.5e-07 28.9 0.9 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.4 029512.2_32929001_3 - 2.5e-06 27.5 0.0 4.4e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Lipase_GDSL PF00657.20 001082025.1_37926001_1 - 3.3e-15 56.5 0.0 5.1e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase SapB_2 PF03489.15 001082025.1_37926001_1 - 7e-05 22.7 0.5 7e-05 22.7 0.5 2.3 2 0 0 2 2 2 1 Saposin-like type B, region 2 Cu-binding_MopE PF11617.6 001082025.1_37926001_1 - 0.00064 19.7 2.6 0.0019 18.2 2.6 1.8 1 0 0 1 1 1 1 Putative metal-binding motif Lipase_GDSL_2 PF13472.4 001082025.1_37926001_1 - 0.00081 19.7 0.0 0.0013 19.0 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family CLU_N PF15044.4 001082025.1_37926001_1 - 0.088 13.1 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial function, CLU-N-term Hist_deacetyl PF00850.17 001102056.1_06523001_2 - 8e-49 166.6 0.0 8e-49 166.6 0.0 1.4 2 0 0 2 2 2 1 Histone deacetylase domain RNA_polI_A34 PF08208.9 001102056.1_06523001_2 - 2.2 8.2 35.4 3.1 7.7 35.4 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 PMP22_Claudin PF00822.18 053351.1_45723001_1 - 1.3e-57 194.1 1.7 1.8e-57 193.7 1.7 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.4 053351.1_45723001_1 - 3.4e-21 75.7 0.7 7e-21 74.7 0.9 1.4 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction CD20 PF04103.13 053351.1_45723001_1 - 0.066 13.2 4.6 0.7 9.8 1.6 2.4 2 1 0 2 2 2 0 CD20-like family zf-CGNR PF11706.6 053351.1_45723001_3 - 0.062 13.0 6.8 0.094 12.4 0.3 2.5 2 0 0 2 2 2 0 CGNR zinc finger PP1_inhibitor PF05361.10 214115.1_49822001_1 - 1.4e-32 112.5 0.5 1.9e-32 112.1 0.5 1.1 1 0 0 1 1 1 1 PKC-activated protein phosphatase-1 inhibitor zf-C4 PF00105.16 001131029.1_39524001_1 - 4.2e-31 107.1 15.0 7.5e-31 106.3 15.0 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.28 001131029.1_39524001_1 - 4.2e-28 98.2 0.9 7.8e-28 97.3 0.9 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor ISAV_HA PF06215.9 001131029.1_39524001_1 - 0.23 9.8 1.2 0.36 9.2 1.2 1.2 1 0 0 1 1 1 0 Infectious salmon anaemia virus haemagglutinin UDPGT PF00201.16 001133679.2_43526001_2 - 8.7e-226 750.4 0.2 1.1e-225 750.0 0.2 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.14 001133679.2_43526001_2 - 4.1e-06 26.7 0.0 6.8e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Pro_3_hydrox_C PF05373.9 001133679.2_43526001_2 - 0.14 12.1 0.1 0.31 11.0 0.1 1.5 1 0 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal Ras PF00071.20 001031788.1_49822001_1 - 2e-63 212.7 0.1 2.4e-63 212.5 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001031788.1_49822001_1 - 2.2e-35 121.3 0.3 3.8e-35 120.6 0.1 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001031788.1_49822001_1 - 2.5e-12 46.4 0.1 3.3e-12 46.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.21 001031788.1_49822001_1 - 2.1e-07 30.9 0.1 3.4e-07 30.2 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001031788.1_49822001_1 - 3.7e-05 23.6 0.1 0.015 15.0 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_22 PF13401.4 001031788.1_49822001_1 - 3.7e-05 23.9 0.1 0.00041 20.5 0.0 2.2 2 1 0 2 2 2 1 AAA domain GTP_EFTU PF00009.25 001031788.1_49822001_1 - 0.00011 21.7 0.1 0.00036 20.0 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.4 001031788.1_49822001_1 - 0.0058 16.9 0.1 0.012 15.9 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain Gtr1_RagA PF04670.10 001031788.1_49822001_1 - 0.0069 15.6 0.0 0.01 15.0 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.16 001031788.1_49822001_1 - 0.0099 15.3 0.1 0.034 13.6 0.1 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.25 001031788.1_49822001_1 - 0.014 15.8 0.1 0.02 15.3 0.1 1.6 1 1 0 1 1 1 0 ABC transporter PduV-EutP PF10662.7 001031788.1_49822001_1 - 0.019 14.5 0.0 0.05 13.2 0.0 1.6 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.8 001031788.1_49822001_1 - 0.034 13.5 0.0 0.075 12.3 0.0 1.6 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.4 001031788.1_49822001_1 - 0.038 13.9 0.1 0.1 12.5 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.4 001031788.1_49822001_1 - 0.042 13.4 0.0 0.075 12.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.4 001031788.1_49822001_1 - 0.074 13.2 0.1 1.7 8.7 0.0 2.6 1 1 1 3 3 3 0 AAA domain TniB PF05621.9 001031788.1_49822001_1 - 0.085 11.9 0.1 0.2 10.7 0.0 1.9 2 1 0 2 2 2 0 Bacterial TniB protein AAA_5 PF07728.12 001031788.1_49822001_1 - 0.12 12.2 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_21 PF13304.4 001031788.1_49822001_1 - 0.13 11.9 0.6 0.24 11.1 0.5 1.5 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.4 001031788.1_49822001_1 - 0.15 11.7 0.0 0.37 10.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF2457 PF10446.7 214117.1_49821001_1 - 6.4 5.7 7.5 6.5 5.7 7.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Hepcidin PF06446.10 214117.1_49821001_2 - 4.8e-16 58.8 10.3 8e-16 58.0 10.3 1.4 1 0 0 1 1 1 1 Hepcidin ERbeta_N PF12497.6 001009737.1_39524001_1 - 6.7e-51 170.7 4.7 1.3e-50 169.8 4.7 1.5 1 0 0 1 1 1 1 Estrogen receptor beta Hormone_recep PF00104.28 001009737.1_39524001_1 - 2.7e-36 125.0 1.6 3.8e-36 124.5 1.6 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.16 001009737.1_39524001_1 - 3.9e-31 107.2 13.1 3.9e-31 107.2 13.1 1.8 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Peptidase_M28 PF04389.15 214001.1_49825001_3 - 8.5e-13 48.3 0.0 1.5e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 TFR_dimer PF04253.13 214001.1_49825001_3 - 4.2e-10 39.7 0.5 1.3e-09 38.1 0.1 2.0 2 0 0 2 2 2 1 Transferrin receptor-like dimerisation domain PA PF02225.20 214001.1_49825001_3 - 2.5e-09 37.0 0.0 6.8e-09 35.6 0.0 1.7 1 0 0 1 1 1 1 PA domain N6-adenineMlase PF10237.7 001108360.1_45725001_1 - 6e-12 45.5 0.1 9.6e-12 44.8 0.1 1.2 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase zf-CCHC PF00098.21 001108360.1_45725001_1 - 0.016 15.1 0.9 0.016 15.1 0.9 3.1 3 0 0 3 3 3 0 Zinc knuckle BRCT PF00533.24 001108360.1_45725001_1 - 0.044 14.1 0.0 0.098 12.9 0.0 1.5 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain zf-GRF PF06839.10 001108360.1_45725001_2 - 5.5e-15 55.1 3.1 1.3e-14 53.8 3.1 1.7 1 0 0 1 1 1 1 GRF zinc finger N6-adenineMlase PF10237.7 001108360.1_45725001_2 - 0.096 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase RNA_POL_M_15KD PF02150.14 001108360.1_45725001_2 - 0.099 12.4 1.6 1.2 8.9 0.0 2.9 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit Med9 PF07544.11 001082351.1_37928001_2 - 0.0032 17.4 7.2 0.0032 17.4 7.2 9.9 8 3 1 10 10 10 3 RNA polymerase II transcription mediator complex subunit 9 TPR_MLP1_2 PF07926.10 001082351.1_37928001_2 - 0.0089 16.0 21.3 0.0089 16.0 21.3 10.2 8 3 2 10 10 10 2 TPR/MLP1/MLP2-like protein 7tm_1 PF00001.19 213773.1_49823001_1 - 4.5e-51 173.5 14.8 1.2e-50 172.2 14.8 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CXCR4_N PF12109.6 213773.1_49823001_1 - 2.5e-16 59.5 3.2 3.7e-16 58.9 3.2 1.3 1 0 0 1 1 1 1 CXCR4 Chemokine receptor N terminal 7TM_GPCR_Srsx PF10320.7 213773.1_49823001_1 - 4.2e-05 22.9 13.8 6.1e-05 22.4 13.8 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF4538 PF15061.4 213773.1_49823001_1 - 0.23 11.1 1.3 0.27 10.9 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4538) PRA1 PF03208.17 001048073.1_49823001_3 - 1e-37 128.8 7.1 1.5e-37 128.3 7.1 1.3 1 0 0 1 1 1 1 PRA1 family protein Halogen_Hydrol PF10112.7 001048073.1_49823001_3 - 0.27 11.1 3.4 1.6 8.6 3.4 1.9 1 1 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein CitMHS PF03600.14 001048073.1_49823001_3 - 0.51 9.4 10.4 0.76 8.8 10.4 1.2 1 0 0 1 1 1 0 Citrate transporter Sulfatase PF00884.21 001163953.1_21024001_1 - 1.2e-92 310.5 0.0 1.5e-92 310.2 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.4 001163953.1_21024001_1 - 1.2e-42 145.4 2.0 2.2e-42 144.6 2.0 1.4 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.20 001163953.1_21024001_1 - 6.1e-08 32.5 0.2 0.0022 17.5 0.0 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase CitMHS PF03600.14 001163953.1_21024001_1 - 0.0059 15.8 0.2 0.0093 15.1 0.2 1.2 1 0 0 1 1 1 1 Citrate transporter DUF4976 PF16347.3 001163953.1_21024001_1 - 0.021 14.9 0.1 9.5 6.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4976) Glyoxalase PF00903.23 001101953.1_06524001_1 - 4.3e-08 33.3 0.0 0.0042 17.1 0.0 2.5 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CppA_N PF14506.4 001101953.1_06524001_1 - 0.0078 16.1 0.0 0.35 10.8 0.0 2.3 2 0 0 2 2 2 1 CppA N-terminal Glyoxalase_4 PF13669.4 001101953.1_06524001_1 - 0.18 12.0 0.0 0.41 10.8 0.0 1.6 1 0 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PNMA PF14893.4 001076197.1_06525001_2 - 3.2e-41 141.7 0.5 4.3e-41 141.3 0.5 1.1 1 0 0 1 1 1 1 PNMA zf-C2H2_10 PF16588.3 001076197.1_06525001_2 - 0.0092 15.6 3.9 0.018 14.6 3.9 1.5 1 0 0 1 1 1 1 C2H2 zinc-finger zf-CCHC PF00098.21 001076197.1_06525001_2 - 0.14 12.2 2.8 0.27 11.2 2.8 1.5 1 0 0 1 1 1 0 Zinc knuckle Actin PF00022.17 001101682.2_37923001_2 - 1.4e-149 498.0 0.0 4.3e-149 496.4 0.0 1.6 1 1 0 1 1 1 1 Actin 7tm_1 PF00001.19 001009030.1_39723001_1 - 2.6e-43 148.1 12.8 3.7e-43 147.6 12.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Srg PF02118.19 001009030.1_39723001_1 - 6.3e-07 29.2 11.4 6.3e-07 29.2 11.4 1.6 2 0 0 2 2 2 1 Srg family chemoreceptor 7TM_GPCR_Srv PF10323.7 001009030.1_39723001_1 - 5.2e-06 25.9 11.0 7.8e-06 25.3 11.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Shisa PF13908.4 001009030.1_39723001_1 - 0.11 12.6 2.2 0.32 11.1 1.0 2.2 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator DUF1110 PF06533.10 001009030.1_39723001_3 - 0.15 11.9 0.3 0.22 11.3 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1110) Syndecan PF01034.18 013026.2_45727001_2 - 4.7e-26 90.4 0.0 7.6e-26 89.7 0.0 1.3 1 0 0 1 1 1 1 Syndecan domain F420_oxidored PF03807.15 133314.1_45726001_2 - 1.1e-16 61.0 0.0 1.8e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Ferric_reduct PF01794.17 133314.1_45726001_2 - 1.7e-11 44.2 5.7 1.7e-11 44.2 5.7 1.8 1 1 1 2 2 2 1 Ferric reductase like transmembrane component Shikimate_DH PF01488.18 133314.1_45726001_2 - 0.013 15.4 0.0 0.022 14.7 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.13 133314.1_45726001_2 - 0.051 13.6 0.0 0.088 12.8 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Ras PF00071.20 001123180.1_49822001_1 - 6.7e-63 211.0 0.3 7.8e-63 210.8 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.11 001123180.1_49822001_1 - 2.5e-35 121.2 0.1 5.8e-35 120.0 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.19 001123180.1_49822001_1 - 1.2e-12 47.5 0.0 1.5e-12 47.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.10 001123180.1_49822001_1 - 3e-05 23.4 0.0 3.9e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.21 001123180.1_49822001_1 - 6.4e-05 22.9 0.0 0.0001 22.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.14 001123180.1_49822001_1 - 0.00049 19.9 0.3 0.32 10.7 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 GTP_EFTU PF00009.25 001123180.1_49822001_1 - 0.0025 17.3 0.0 0.0056 16.1 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.4 001123180.1_49822001_1 - 0.012 15.8 0.1 0.019 15.2 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain MCR_beta PF02241.16 001123180.1_49822001_1 - 0.028 13.9 0.1 0.035 13.6 0.1 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, C-terminal domain BrnT_toxin PF04365.11 001123180.1_49822001_1 - 0.069 13.4 0.1 0.54 10.5 0.0 2.1 2 0 0 2 2 2 0 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system DnaJ PF00226.29 001033165.3_32924001_3 - 2.3e-19 69.1 0.0 5.4e-19 68.0 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain Potyvirid-P3 PF13608.4 001033165.3_32924001_3 - 0.12 11.2 1.7 0.27 10.1 1.7 1.5 2 0 0 2 2 2 0 Protein P3 of Potyviral polyprotein L31 PF09784.7 001033165.3_32924001_3 - 0.31 11.4 3.6 0.73 10.1 3.6 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L31 TNFR_c6 PF00020.16 001081902.1_21023001_2 - 7.8e-16 58.1 33.6 1.5e-05 25.1 0.2 4.7 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region Glycophorin_A PF01102.16 001081902.1_21023001_2 - 0.21 11.7 0.0 0.37 10.9 0.0 1.3 1 0 0 1 1 1 0 Glycophorin A Arfaptin PF06456.11 053460.1_45724001_1 - 2e-85 285.9 2.0 3.2e-85 285.2 2.0 1.3 1 0 0 1 1 1 1 Arfaptin-like domain PDZ PF00595.22 053460.1_45724001_1 - 1.7e-10 40.9 0.2 3e-10 40.2 0.2 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) BAR PF03114.16 053460.1_45724001_1 - 4.5e-06 26.4 1.9 3.7e-05 23.3 1.9 2.0 1 1 0 1 1 1 1 BAR domain PDZ_2 PF13180.4 053460.1_45724001_1 - 9.6e-06 25.7 0.1 3.4e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 PDZ domain BAR_3 PF16746.3 053460.1_45724001_1 - 0.00016 21.3 1.8 0.12 11.9 0.4 2.2 2 0 0 2 2 2 2 BAR domain of APPL family GRASP55_65 PF04495.12 053460.1_45724001_1 - 0.13 12.4 0.0 1.3 9.2 0.0 2.1 2 0 0 2 2 2 0 GRASP55/65 PDZ-like domain RasGEF PF00617.17 053721.1_45728001_1 - 4.1e-56 189.7 0.3 1.1e-55 188.3 0.3 1.8 1 0 0 1 1 1 1 RasGEF domain RhoGEF PF00621.18 053721.1_45728001_1 - 2.9e-31 109.0 1.3 2.9e-31 109.0 1.3 2.8 3 0 0 3 3 3 1 RhoGEF domain RasGEF_N PF00618.18 053721.1_45728001_1 - 3.1e-26 91.5 0.3 5e-20 71.6 0.2 3.2 2 0 0 2 2 2 2 RasGEF N-terminal motif PH PF00169.27 053721.1_45728001_1 - 2e-22 79.6 0.0 1.9e-14 53.9 0.0 2.7 2 0 0 2 2 2 2 PH domain PH_11 PF15413.4 053721.1_45728001_1 - 0.0039 17.5 0.9 0.17 12.2 0.9 3.1 1 1 0 1 1 1 1 Pleckstrin homology domain IQ PF00612.25 053721.1_45728001_1 - 0.011 15.3 3.4 0.026 14.2 1.8 2.4 2 0 0 2 2 2 0 IQ calmodulin-binding motif HTH_IclR PF09339.8 053721.1_45728001_1 - 0.19 11.4 0.4 3.9 7.2 0.0 2.9 3 0 0 3 3 3 0 IclR helix-turn-helix domain DUF641 PF04859.10 053721.1_45728001_1 - 1.4 9.1 8.9 0.03 14.5 1.1 2.3 3 0 0 3 3 3 0 Plant protein of unknown function (DUF641) DUF4795 PF16043.3 053721.1_45728001_1 - 2.1 7.8 9.1 0.54 9.7 2.4 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4795) Pyr_redox_2 PF07992.12 214062.1_49825001_2 - 3.4e-66 223.3 6.4 3.4e-66 223.3 6.4 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.20 214062.1_49825001_2 - 9.4e-43 144.8 0.4 2.8e-42 143.3 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.25 214062.1_49825001_2 - 1.1e-15 57.8 7.1 1.7e-14 54.0 1.5 2.8 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.5 214062.1_49825001_2 - 9.9e-09 34.9 0.0 9.9e-09 34.9 0.0 2.3 2 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.4 214062.1_49825001_2 - 4.4e-08 33.1 2.1 5e-05 23.3 0.1 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.4 214062.1_49825001_2 - 8.3e-08 31.7 5.2 2.3e-05 23.6 0.3 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.22 214062.1_49825001_2 - 2.5e-06 26.7 0.2 2.5e-06 26.7 0.2 2.8 3 0 0 3 3 2 2 FAD binding domain GIDA PF01134.20 214062.1_49825001_2 - 1.5e-05 24.1 4.6 1.5e-05 24.1 4.6 2.7 2 1 0 2 2 2 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.19 214062.1_49825001_2 - 3.6e-05 23.0 3.8 0.044 13.0 0.7 2.6 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain K_oxygenase PF13434.4 214062.1_49825001_2 - 0.00048 19.2 0.2 0.19 10.7 0.2 2.4 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.12 214062.1_49825001_2 - 0.0011 17.7 0.5 0.0011 17.7 0.5 3.3 4 0 0 4 4 4 2 HI0933-like protein FAD_binding_3 PF01494.17 214062.1_49825001_2 - 0.0017 17.6 4.8 0.018 14.2 0.1 3.0 3 0 0 3 3 3 1 FAD binding domain Thi4 PF01946.15 214062.1_49825001_2 - 0.002 17.3 0.8 0.0034 16.5 0.0 1.7 2 0 0 2 2 2 1 Thi4 family UDPG_MGDP_dh_N PF03721.12 214062.1_49825001_2 - 0.39 10.1 6.3 3.1 7.2 0.2 3.0 3 0 0 3 3 3 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.16 214062.1_49825001_2 - 0.5 10.1 3.8 3.9 7.2 0.5 2.4 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain p450 PF00067.20 214424.1_49825001_3 - 1.6e-128 429.3 0.0 1.8e-128 429.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 STAR_dimer PF16544.3 001159517.1_32929001_3 - 9.3e-27 92.2 0.1 1.9e-26 91.3 0.1 1.5 1 0 0 1 1 1 1 Homodimerisation region of STAR domain protein Quaking_NLS PF16551.3 001159517.1_32929001_3 - 4.7e-20 70.8 5.1 9e-20 69.9 5.1 1.5 1 0 0 1 1 1 1 Putative nuclear localisation signal of quaking KH_1 PF00013.27 001159517.1_32929001_3 - 2.4e-05 23.9 0.0 4.2e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 KH domain Pkinase PF00069.23 031599.2_45729001_2 - 1.6e-50 171.8 0.0 4e-37 127.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.15 031599.2_45729001_2 - 3.3e-31 108.4 0.0 1.4e-23 83.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.4 031599.2_45729001_2 - 4.8e-07 29.2 0.0 9.4e-07 28.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like PQQ_2 PF13360.4 031599.2_45729001_2 - 3.4e-06 26.7 0.2 0.083 12.3 0.0 2.6 1 1 0 2 2 2 2 PQQ-like domain Kdo PF06293.12 031599.2_45729001_2 - 0.0015 17.8 0.7 0.0027 16.9 0.1 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family PQQ PF01011.19 031599.2_45729001_2 - 0.0061 16.3 1.2 0.1 12.4 0.0 3.3 4 0 0 4 4 4 1 PQQ enzyme repeat APH PF01636.21 031599.2_45729001_2 - 0.022 14.6 0.0 0.042 13.6 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family PQQ_3 PF13570.4 031599.2_45729001_2 - 0.046 14.1 0.1 4.3 7.8 0.0 3.4 3 0 0 3 3 3 0 PQQ-like domain ATG13 PF10033.7 001098543.1_39726001_1 - 9.3e-14 51.5 0.1 2.2e-07 30.6 0.1 2.6 1 1 1 2 2 2 2 Autophagy-related protein 13 Dsh_C PF12316.6 007888.3_32926001_3 - 2e-72 243.9 27.1 2e-72 243.9 27.1 2.9 2 1 0 3 3 3 1 Segment polarity protein dishevelled (Dsh) C terminal Dishevelled PF02377.13 007888.3_32926001_3 - 3.7e-58 196.3 19.2 3.7e-58 196.3 19.2 1.8 2 0 0 2 2 2 1 Dishevelled specific domain DIX PF00778.15 007888.3_32926001_3 - 1.6e-32 111.1 0.0 2.5e-32 110.4 0.0 1.3 1 0 0 1 1 1 1 DIX domain PDZ PF00595.22 007888.3_32926001_3 - 5.8e-18 64.9 0.3 1.1e-17 64.0 0.3 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) DEP PF00610.19 007888.3_32926001_3 - 9.8e-17 60.6 0.0 2.1e-16 59.6 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PDZ_2 PF13180.4 007888.3_32926001_3 - 0.012 15.7 0.3 0.027 14.7 0.1 1.6 2 0 0 2 2 2 0 PDZ domain Shufflon_N PF04917.10 007888.3_32926001_3 - 0.05 12.9 0.1 0.079 12.3 0.1 1.2 1 0 0 1 1 1 0 Bacterial shufflon protein, N-terminal constant region DUF3538 PF12057.6 001145382.1_49828001_3 - 7.5e-43 144.8 0.1 2.1e-42 143.3 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3538) ubiquitin PF00240.21 001145382.1_49828001_3 - 5.8e-16 57.9 0.2 1e-15 57.1 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.6 001145382.1_49828001_3 - 5.4e-05 22.8 0.2 0.0001 22.0 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.7 001145382.1_49828001_3 - 0.014 15.8 0.0 0.11 12.9 0.0 2.4 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.4 001145382.1_49828001_3 - 0.025 14.5 0.0 0.058 13.4 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF2939 PF11159.6 001145382.1_49828001_3 - 0.19 12.0 0.3 0.44 10.9 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2939) CoA_trans PF01144.21 213938.1_49824001_1 - 1e-126 420.5 1.7 2e-77 259.3 0.2 2.0 2 0 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.4 213938.1_49824001_1 - 0.0086 15.9 0.1 0.017 14.9 0.1 1.4 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain PDGF PF00341.15 031524.1_45724001_3 - 1e-22 80.0 10.8 2.1e-22 79.1 10.8 1.5 1 0 0 1 1 1 1 PDGF/VEGF domain PDGF_N PF04692.11 031524.1_45724001_3 - 4.8e-18 65.6 0.4 1.1e-17 64.5 0.4 1.6 1 0 0 1 1 1 1 Platelet-derived growth factor, N terminal region Arrestin_N PF00339.27 001044614.2_49824001_2 - 3.4e-23 82.2 0.0 6e-23 81.4 0.0 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.20 001044614.2_49824001_2 - 3.8e-12 46.6 0.0 3.1e-11 43.6 0.0 2.1 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain # # Program: hmmscan # Version: 3.1b2 (February 2015) # Pipeline mode: SCAN # Query file: /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/smallRNE/simple/part8/wd/simple8.p.fa # Target file: /home/yduan/database/Pfam/Pfam-A.hmm # Option settings: hmmscan -o /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/smallRNE/simple/part8/hmmscan.outm --tblout /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/smallRNE/simple/part8/hmmscan.t.out /home/yduan/database/Pfam/Pfam-A.hmm /home/yduan/work_file/lncRNAdb/methods_assement/prediction_results/smallRNE/simple/part8/wd/simple8.p.fa # Current dir: /home/yduan/work_file/lncRNAdb/methods_assement # Date: Tue Jul 10 07:48:28 2018 # [ok]